ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Primary Health Care

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: LONDON SCH/HYGIENE & TROPICAL MEDICINE

ORG_ZIPCODE: WC1E 7HT

PHR: PROJECT NARRATIVE    IMPRESS  comprises  a  cluster  RCT  to  evaluate  the  impact  of  the  integration  of  a  community  intervention  to  address  demand  side  barriers  to  depression  care  on  contact  and  effectiveness  coverage of an evidence based brief psychological treatment for depression in primary care in India.

PI_NAMEs: NADKARNI, ABHIJIT  (contact);PATEL, VIKRAM H

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adoption;Affect;Attitude;Canada;care seeking;Caring;Clinical;Collaborations;Communities;Community Healthcare;community intervention;cost effective;cost effectiveness;cost estimate;depressive symptoms;Development;disability;economic evaluation;economic outcome;Effectiveness;effectiveness/implementation hybrid;Evaluation;evidence base;Evidence based intervention;Goals;Government;Health care facility;health literacy;Health Professional;Health Services;help-seeking behavior;implementation framework;implementation research;implementation science;implementation strategy;improved;improved outcome;India;Individual;individual patient;innovation;Institution;Intervention;intervention delivery;Knowledge;low and middle-income countries;Maintenance;Mediation;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Modeling;Morbidity - disease rate;novel;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Population;Primary Care;Primary Health Care;productivity loss;Professional counselor;programs;psychologic;psychosocial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduce symptoms;Reporting;Research;Resource-limited setting;satisfaction;scale up;Side;Social outcome;social stigma;System;Time trend;treatment adherence;Treatment Effectiveness;uptake

PROJECT_TITLE: IMPlementation of evidence based facility and community interventions to reduce the treatment gap for depRESSion (IMPRESS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDA-A(50)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Precise and robust regulation of gene expression through chromatin regulation is critical for proper human development; disruptions to regulation of chromatin regulatory proteins is at fault in a number of human diseases. Heterochromatin gene repression, one of the focus areas of this proposed research is at fault in multiple developmental disorders, neurological diseases, as well as cancer thus our findings could lead to a better understanding of human disease. In this work we explore multiple mechanisms contributing to heterochromatin gene repression as well as develop new chemical-based technologies that use bifunctional molecules to alter chromatin structure as an approach to learn more about chromatin regulation.

PI_NAMEs: HATHAWAY, NATHANIEL A. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Area;Binding Proteins;Cells;Chemicals;Chromatin;Chromatin Structure;developmental disease;drug discovery;Enzymes;Gene Expression;Gene Expression Regulation;gene repression;genetic regulatory protein;Goals;Grant;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Human Development;human disease;inhibitor;Learning;Lighting;Malignant Neoplasms;mammalian genome;Methylation;Nervous System Disorder;Pathway interactions;programs;recruit;Regulation;Regulatory Pathway;Research;Site;small molecule;Technology;Time;Visualization;Work

PROJECT_TITLE: ILLUMINATION OF CHROMATIN REGULATION VIA CHEMICAL CONTROLLED PROXIMITY

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE The Indiana Medical Scientist Training Program (MSTP) is strongly supported by the Indiana University School of Medicine and by several Foundations to train the next generation of physician-scientists, placing graduates in top residency and research programs across the nation and preparing graduates to be leading investigators and innovators in academia and industry. It is particularly focused on training physician-engineers, in partnership with – and strongly supported by - the Purdue University Weldon School of Biomedical Engineering. We emphasize both strong mentorship training and a culture of diversity and inclusiveness, being one of the most diverse programs in the Midwest and having recently received substantial grants further to increase diversity in Indiana STEM education and recruitment of MSTP scholars and mentors.

PI_NAMEs: GASTON, BENJAMIN  (contact);HERBERT, BRITTNEY-SHEA

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Indiana Medical Scientist/Engineer Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Cocaine;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: STONY BROOK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: We propose to develop artificial intelligence (AI) enhanced fluorescence and optical Doppler microscope for imaging of astrocytic Ca2+ (Ca2+A), neuronal Ca2+ (Ca2+N) activities and cerebral blood flow velocity (CBFv) of awake animals. AI frameworks will be used to effectively minimize motion artifacts and denoise time-lapse images, from which spatiotemporal analyses will be applied to derive Ca2+A, Ca2+N, CBFv synchronization via their resting-state low-frequency oscillations (<1Hz) in medial frontal cortex (mPFC) of naïve mice and mice with chronic administration of cocaine. Successful completion of the proposed research and development will have a broad impact on neuroscience and drug addiction that require high-resolution, simultaneous imaging of neuro- astroglio-vascular effects in the brain of awake animals. This translational research is of clinical relevance to drug addiction – a highly prevalent public health problem.

PI_NAMEs: DU, CONGWU ;LING, HAIBIN ;PAN, YINGTIAN  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: 3-Dimensional;addiction;Affect;Animals;Artificial Intelligence;Artificial Intelligence enhanced;Astrocytes;awake;Biomedical Engineering;Blood capillaries;Blood Flow Velocity;Blood Vessels;Brain;Cells;cerebral capillary;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrovascular system;Chronic;clinically relevant;Cocaine;cocaine exposure;Complement;computer scientist;denoising;designer receptors exclusively activated by designer drugs;detection sensitivity;Development;Drug Addiction;Exposure to;Fluorescence;fluorescence imaging;Frequencies;frontal lobe;Functional disorder;Genetic;Goals;Image;imaging platform;Imaging Techniques;in vivo optical imaging;Induced Neurons;innovation;insight;Interdisciplinary Study;Measures;Medial;Mediating;Mediation;Microscope;microscopic imaging;Modality;Morphologic artifacts;Motion;Mus;National Institute of Drug Abuse;Neuroglia;neuroimaging;neuronal excitability;neuronal metabolism;Neurons;Neurosciences;neurovascular coupling;Noise;novel;Optical Coherence Tomography;Optics;Prefrontal Cortex;prevent;programs;Public Health;Reaction;Research;research and development;Resolution;response;Rest;Role;Scientist;Signal Transduction;spatiotemporal;Techniques;tool;Translational Research;Viral

PROJECT_TITLE: Imaging neural, astrocytic and vascular synchronization to assess cocaine's effects on mPFC


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Hundreds of thousands of genomic regions have been associated with human traits and diseases, yet in few instances do we know the identity of the exact causal mutation nor the molecular mechanism behind its function. This proposal aims develop new tools to mutagenize gene regulatory elements in the genome and build a catalog of epigenetic and transcriptional phenotypes from over 300,000 mutations. This catalog will be used to augment advanced machine learning models to better understand the underlying rules of how variants function, as to better predict the impact of individual mutations linked to human health and disease.

PI_NAMEs: REILLY, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Alleles;Architecture;Binding;Biological Assay;Catalogs;causal variant;CCRL2 gene;Cells;ChIP-seq;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;computer framework;CRISPR screen;CRISPR/Cas technology;Data;Deposition;Detection;Development;Disease;disorder risk;Dissection;Epigenetic Process;Etiology;experimental study;functional genomics;Gene Expression;gene interaction;Gene Targeting;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genomic Segment;Genomics;Goals;Health;Human;Human Genetics;Human Genome;improved;Individual;insight;Investigation;Knowledge;Link;Lipids;Location;Logic;Machine Learning;machine learning model;machine learning prediction;Maps;Mediating;Metabolic;Metabolic Diseases;Modeling;Molecular;Mutagenesis;Mutagens;Mutation;network architecture;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;Phenotype;Population;prediction algorithm;predictive modeling;Regulatory Element;Structure;System;Techniques;tool;Training;trait;Transcript;transcription factor;Transcriptional Regulation;transcriptome;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Multi-scale functional dissection and modeling of regulatory variation associated with human traits


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Opioid use disorder (OUD) represents an urgent public health crisis for which available therapeutics have proven insufficiently efficacious. While most of the research surrounding opioid addiction has focused on how neurons communicate with one another, less attention has been given to other brain cell types and mechanisms that have also been shown to affect aspects of addiction, such as neuroinflammation induced by microglia – the resident immune cells of the central nervous system. Given that microglial activation is under epigenetic control, the proposed research seeks to understand the epigenetic mechanisms that govern microglial activation across different phases of OUD, with the goal of developing more effective therapeutics for this devastating disease.

PI_NAMEs: TUESTA, LUIS MIGUEL (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Attention;Brain;brain cell;cell type;Cells;Central Nervous System;Chemicals;Chronic;Communication;cost;craving;Disease;Drug Addiction;effective therapy;Epigenetic Process;epigenetic regulation;Event;experimental study;genetic manipulation;Genetic Transcription;glial activation;Goals;Health;Histones;Homeostasis;Immune;Intravenous;Ischemia;Legal;long term abstinence;Lysine;Maintenance;Medical;Methylation;Microglia;Modification;mouse model;National Institute of Drug Abuse;neuroinflammation;Neurons;novel therapeutics;Opiate Addiction;Opioid;Opioid Analgesics;opioid overdose;opioid use disorder;overdose death;Pharmaceutical Preparations;pharmacologic;Phase;Physiological Processes;prescription opioid misuse;Productivity;programs;Proteins;Public Health;Recurrent disease;Relapse;relapse prevention;remifentanil;Research;response;Rewards;Role;Self Administration;social;stem;System;Therapeutic;therapeutically effective;web site;Withdrawal

PROJECT_TITLE: Microglia and Epigenetic Regulation in Opioid Addiction


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Understanding how the right ventricle (RV) adapts to the increased pulmonary vascular resistance in pulmonary hypertension and which molecular mechanisms and structural changes lead to RV failure, will help us develop novel therapies to strengthen the RV and prevent RV failure. We will test two repurposed drugs, Tacrolimus (FK506) and Enzastaurin in our mouse model of RV pressure- overload, to evaluate whether they can prevent and reverse RV failure. Given that these two drugs are ready to be tested in clinical trials, our research is in line with the NIH’s mission to increase knowledge to enhance health, lengthen life, and reduce illness and disability by applying fundamental knowledge of RV adaptation.

PI_NAMEs: SPIEKERKOETTER, EDDA FRAUKE (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Architecture;Blood capillaries;Blood Vessels;bone morphogenetic protein receptors;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cause of Death;Cells;Chronic;Chronic pulmonary heart disease;Clinical;Clinical Trials;congenital heart abnormality;coronary fibrosis;density;Dependence;Diffusion;disability;Disease;drug repurposing;druggable target;Early identification;Etiology;Event;Failure;Fibroblasts;Fibrosis;FK506;Genetic;Health;heart function;Histologic;histological studies;Human Rights;Hypoxia;Impairment;improved;Ischemia;Knowledge;Left;Life;Link;Liquid substance;Location;Lung;Medical;Microcirculation;Mission;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;novel;novel therapeutics;Nutrient;Oxygen;Pathologic;Pharmaceutical Preparations;pressure;prevent;Process;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Embolism;Pulmonary Hypertension;Pulmonary Vascular Resistance;Radial;Recovery;Recovery of Function;Research;right ventricular failure;Right Ventricular Hypertrophy;Right ventricular strain;Right ventricular structure;Risk;Role;Signal Transduction;Snails;Spatial Distribution;Surface;Surgical sutures;Tacrolimus;Testing;Therapeutic;Three-Dimensional Imaging;three-dimensional modeling;thrombolysis;Tissue imaging;Tissues;tool;United States National Institutes of Health;Ventricular

PROJECT_TITLE: Understanding and targeting molecular as well as structural events governing right ventricular adaptation, failure and recovery in pulmonary hypertension using repurposed drugs

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BURNABY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SIMON FRASER UNIVERSITY

ORG_STATE: BC

ORG_ZIPCODE: V5A 1S6

PHR: PROJECT NARRATIVE The purpose of this proposed cohort study is to examine the impact of evolving substance use patterns on HIV prevention and HIV-associated co-morbidities. This study will involve 1800 participants in Vancouver, Canada, including HIV-negative adults who inject drugs and street-involved drug-using youth.

PI_NAMEs: DEBECK, KORA ;HAYASHI, KANNA  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: addiction;Address;Adherence;adolescent drug use;Adult;aged;AIDS prevention;American;Area;barrier to care;Basic Science;Biological Markers;British Columbia;Canada;Charge;Cities;cohort;Cohort Studies;Communities;comorbidity;cost;cost effectiveness;data access;data harmonization;Development;Disease;Disease Outbreaks;Drug usage;Drug user;effectiveness study;Environment;Environmental Risk Factor;Epidemic;Ethnography;Evaluation;Event;experience;Funding;Future;Grant;Growth;Health;Healthcare;High Prevalence;high risk;HIV;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Home;illicit drug use;Illicit Drugs;immune activation;implementation science;Incidence;Individual;Inflammation;Injecting drug user;Injections;innovation;Insurance;International;Intervention;Investigation;Long-Term Effects;mathematical model;medication-assisted treatment;Medicine;member;Methamphetamine;methamphetamine use;microbicide;mortality;multidisciplinary;National Institute of Drug Abuse;Neurocognitive Deficit;next generation;NIH Office of AIDS Research;novel strategies;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Pain;pandemic disease;Participant;Pattern;Peer Review;Pharmaceutical Preparations;Policies;Population;Positioning Attribute;pre-exposure prophylaxis;Premature aging syndrome;Prevalence;Productivity;programs;Prospective, cohort study;Public Health;Publications;Qualitative Research;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Research Priority;Resources;response;Running;Sampling;scale up;Scheme;Science;Scientist;Sister;Site;social factors;Stimulant;structural determinants;substance use;synthetic opioid;Training;United States National Institutes of Health;uptake;vaginal microbiome;virtual;willingness;Work

PROJECT_TITLE: Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDS


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative The goal of this study is to generate new knowledge on how children's brains develop and how factors such as maternal depression influence this development. The findings from this study will help us better understand how to improve the health and well-being of vulnerable children.

PI_NAMEs: MASELKO, JOANNA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 8 year old;Acute;Age;Age Months;Biological;Biological Markers;Biological Process;Birth;boys;Brain;Child;Child Development;Child Support;Childhood;Cognitive;cognitive development;cohort;Data;design;Development;early childhood;early life adversity;Economics;Emotional;Evaluation;Exposure to;Generations;girls;Goals;Health;hypothalamic-pituitary-adrenal axis;improved;innovation;insight;intergenerational;Intervention;intimate partner violence;Knowledge;late life;Lead;Life;Life Cycle Stages;Link;Longitudinal Studies;maternal depression;maternal outcome;Mediating;Mental Depression;Mental Health;Methods;Morbidity - disease rate;Mothers;Nursery Schools;offspring;Outcome;Pakistan;peer;Perinatal;peripartum depression;Personal Satisfaction;Physiological;Population;Poverty;Pregnancy;Preschool Child;Prevalence;Primary Schools;programs;psychosocial;Randomized;Research;resilience;Resource-limited setting;Risk;Role;Rural;School-Age Population;Schools;sex;Sex Differences;social;Social Environment;Social support;Stress;Structure;Symptoms;Testing;Thinking;Time;transmission process

PROJECT_TITLE: Early life adversities and the emergence of risk and resilience: a longitudinal study of child development

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Some bacteria release ribotoxins that target protein translation system for cell killing, and others have acquired RNA repair systems to neutralize the toxic effect of ribotoxins for survival. The RNA repair systems appear to be concentrated on pathogenic bacteria. Therefore, blocking RNA repair in these bacteria with small-molecule inhibitors may lead to their demise, resulting in potential prevention and treatment of human diseases.

PI_NAMEs: HUANG, RAVEN H (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Abbreviations;Antidotes;Archaea;Attenuated;Bacteria;Bacterial Proteins;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biological Phenomena;Biological Process;biological systems;Biology;C-terminal;Capnocytophaga;Cell Death;cell killing;Cells;Chimeric Proteins;colicin;Complex;Coupled;Cryoelectron Microscopy;Data;Disabling;Effectiveness;Engineering;Enterobacter cloacae;Escherichia coli;Eukaryota;Event;experimental study;Genes;genome-wide;Homologous Gene;Human;human disease;In Vitro;in vivo;insight;Introns;member;Microbiology;Molecular;Operon;oral pathogen;Organism;pathogenic bacteria;Pathway interactions;Prevention;Proteins;Reaction;release factor;repaired;Research;Ribosomal RNA;Ribosomes;Ricin;RNA;RNA Splicing;Site;small molecule inhibitor;structural biology;Structure;System;Tail;Testing;Time;Toxic effect;Toxin;transcriptome sequencing;Transfer RNA;Translations;Virus;weapons;X-Ray Crystallography

PROJECT_TITLE: Rescue and repair of stalled ribosome damaged by ribosome-specific ribotoxins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project narrative Motile leukocytes in the innate immune system defend our body against viruses, bacteria, and cancer cells. Understanding the cell signaling mechanisms that regulate leukocyte motility could open doors for researchers to develop therapeutics that modulate immune cell functions in order to combat cancer, infection, and inflammation.

PI_NAMEs: HANSEN, SCOTT DAVID (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Actins;Architecture;Bacteria;Behavior;Binding;Biochemical;Biochemistry;Biological Models;Biophysics;Biosensor;C-terminal;cancer cell;Cell Line;Cell membrane;cell motility;Cell Physiology;Cell Polarity;Cell Surface Receptors;Cells;Cellular biology;chemical release;Chemicals;Chemotaxis;Clustered Regularly Interspaced Short Palindromic Repeats;Coin;combat;Communication;CRISPR interference;Cues;Decision Making;Defect;Engineering;Environment;Enzymes;Exhibits;fluorescence imaging;Fluorescence Microscopy;fMet-Leu-Phe receptor;Genetic;genome editing;Goals;Guanosine Triphosphate Phosphohydrolases;Human;Immune;immune modulating agents;Immune response;Immune system;Immunologic Receptors;immunoregulation;In Vitro;Infection;Inflammation;inhibitor;Innate Immune System;inorganic phosphate;Invaded;Knowledge;Leukocytes;Lipid Bilayers;Lipids;live cell imaging;Malignant Neoplasms;Membrane;migration;Molecular;molecular imaging;Monomeric GTP-Binding Proteins;Motility;Movement;mutant;neutrophil;novel therapeutics;optogenetics;pathogen;Pathogenicity;Phenotype;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phosphatidylserines;phosphoinositide-3,4,5-triphosphate;phosphoinositide-3,4-bisphosphate;Phosphoric Monoester Hydrolases;PIK3CG gene;Proteins;Receptor Activation;reconstitution;recruit;Regulation;Reporting;Research;Research Personnel;Role;scaffold;Scaffolding Protein;Signal Transduction;Signaling Molecule;single molecule;Source;System;Techniques;Technology;Testing;tool;Travel;Virus;Visualization

PROJECT_TITLE: Deciphering the mechanism of SHIP1 regulation in human neutrophils


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Kidney Disease;Lupus

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative Systemic lupus erythematosus afflicts young women and is frequently devastating. We now understand that the disease is heterogenous and we need to understand better the diverse mechanisms that are involved in the expression of the disease. In this proposal we plan to understand how an expanded subpopulation of lymphocytes known, as double negative T cells, contributes to the expression of the disease. The gained knowledge will enable the consideration of effective individualized treatment of patients.

PI_NAMEs: TSOKOS, GEORGE C (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: aged;American;Antibodies;Apoptotic;Attention;Autoantigens;Autoimmune Responses;Autoimmunity;autoinflammatory;Autologous;autoreactive T cell;B-Lymphocytes;Biological Markers;CCL20 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chemokine;Color;Cyclic AMP Response Element;cytokine;Cytometry;Data;Development;Disease;Disease Progression;DNA methyltransferase inhibition;Down-Regulation;ds-DNA;Engineering;Environment;Epigenetic Process;Epithelial Cells;experimental study;Exposure to;Generations;Helper-Inducer T-Lymphocyte;Human;IL17 gene;Immunoglobulins;Immunosuppressive Agents;improved;In Vitro;individualized medicine;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Interleukin-10;Interleukin-2;interleukin-23;interstitial;Invaded;Kidney;kidney cell;Knowledge;Learning;Lupus Nephritis;lupus prone mice;Lymphocyte Subset;Macrophage;Morbidity - disease rate;mortality;Mus;Nephritis;nephrogenesis;new technology;novel;Organ;Pathogenicity;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Population;preservation;prevent;Process;Production;programmed cell death protein 1;Quality of life;Rag1 Mouse;Series;Shapes;single-cell RNA sequencing;Surface;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;therapeutic target;tissue injury;Tissues;Transcription Repressor;Tubular formation;Visit;young woman

PROJECT_TITLE: Expanded Double Negative T cells in SLE.

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Native Americans face significant disparities in cardiovascular incidence and mortality rates, but effective hypertension (HTN) self-care behaviors can reduce their healthcare burden and suffering. We propose a randomized controlled trial of a culturally adapted sensor-controlled digital game intervention, to improve NA individuals’ knowledge, skills, and motivation to engage in critical HTN self-care behaviors. This project will generate insight and guidance regarding the use of digital gaming as an affordable, portable, and scalable technology to potentially reduce the burden of HTN among Native Americans.

PI_NAMEs: RADHAKRISHNAN, KAVITA  (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: 18 year old;Accelerometer;Active Learning;Address;Adult;aged;Behavior;Behavioral;blood pressure reduction;Cardiac;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cellular Phone;Clinic;Communities;community based participatory approach;community based participatory research;community building;community intervention;Complement;Control Groups;County;culturally appropriate intervention;Data;Death Rate;Diagnosis;Diastolic blood pressure;digital;digital health;digital intervention;Disparity;Education;Educational Materials;effectiveness testing;efficacy testing;Electronics;evidence base;exercise intervention;Face;Feedback;Goals;group intervention;Guidelines;Habits;Health;health disparity;Health Promotion;healthcare burden;Heart failure;Hospitalization;Hypertension;hypertension control;improved;Incentives;Incidence;insight;Intervention;Interview;Kidney Diseases;Knowledge;Learning;Life Style;Life Style Modification;Lumbee tribe;Measures;member;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Motivation;Native American community;Native American population;Native American Tribe;Native Americans;North Carolina;Obesity;Oklahoma;Outcome;Participant;Physical activity;Physical assessment;Play;Play Therapy;Population;portability;primary outcome;prospective;Quality of life;Randomized;Randomized Controlled Clinical Trials;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Recommendation;recruit;Research Design;response;Rewards;Risk Factors;Sampling;secondary outcome;Self Care;Self Efficacy;sensor;skills;social;Standardization;Stroke;Technology;Testing;Texas;Time;tool;Training;tribal community;Tribes;Weight;Writing

PROJECT_TITLE: A sensor-controlled digital game-based approach to improve self-care behaviors among adults diagnosed with hypertension in a Native American community

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(55)]


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE: This proposal focuses on the mechanism of Wnt signal transduction, which plays an essential role in embryonic development and in adult stem cell maintenance. Our current work focuses on control of Wnt coreceptor stability by the USP46 complex, the role of the tumor suppressor, APC, in regulating Wnt receptor activation, the establishment of bistable behavior by the - catenin destruction complex, and the regulation of Wnt-mediated transcription by the proteins, USP47 and STK38. We now propose to reconstitute LRP6 ubiquitylation, uncover compensation mechanisms that activate signaling in APC mutant cells, determine the contribution of APC in Wnt pathway bistability, and characterize the role of a newly identified component of the Wnt pathway, TRIP12.

PI_NAMEs: LEE, ETHAN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adult;adult stem cell;Agonist;Award;Behavior;Biochemical;Biological Process;cancer initiation;Cell Maintenance;Cells;Clinical Trials;Colorectal Cancer;Compensation;Complex;Defect;Development;Disease;Drug Targeting;egg;Embryonic Development;Familial Adenomatous Polyposis Syndrome;FDA approved;Genetic Transcription;Goals;Human;Malignant Neoplasms;mathematical model;Mediating;Modeling;Molecular;mutant;Mutation;Nuclear;Orphan Drugs;Pathway interactions;Pharmaceutical Preparations;Play;premalignant;protein purification;Proteins;receptor;Receptor Activation;reconstitution;Regulation;Research;Research Personnel;Role;Signal Transduction;small molecule inhibitor;stem cells;System;Tumor Suppressor Proteins;ubiquitin isopeptidase;ubiquitin-protein ligase;WNT Signaling Pathway;Work;Xenopus

PROJECT_TITLE: Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative.  DNA-directed RNA Polymerase II (Pol II) is one of the most important molecules in biology. Pol II is highly- conserved among eukaryotic organisms and plays a fundamental role in cellular life; specifically the transcription of genes into messenger RNA. Pol II studies, and RNA polymerase studies in general, lag the diverse and extensive studies on DNA polymerases where high resolution, atomic level data on conformational changes and chemical groups that drive catalysis and translocation have been revealed. Catalysis and translocation of multi-subunit RNA polymerases underlie all cellular RNA synthesis. Advancing our knowledge will be hugely significant for understanding how these enzymes work and are potentially regulated by initiation and elongation factors. Our preliminary experiments reveal “snapshots of the transcriptional process at different time points”. The studies proposed in this renewal will uncover (for the first time) a “molecular movie” of nucleotide addition and will lead to the fundamental understanding of the mechanisms of DNA mediated transcription. We propose to “direct and produce” a movie of Pol II in the act of transcription that will illuminate the intricacies of one of the most fundamental process in biology.

PI_NAMEs: CALERO, GUILLERMO ALBERTO (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Active Sites;beamline;Binding;Biology;Catalysis;chemical group;Chemistry;Chromatin;Complex;Coupled;Cryoelectron Microscopy;Crystallization;Crystallography;Custom;Data;Data Collection;Data Set;DNA;DNA Damage;DNA lesion;DNA Polymerase I;DNA Polymerase III;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;electron density;Electron Microscopy;Elements;Elongation Factor;Enzymes;Eukaryota;Event;experimental study;Exposure to;Foundations;free-electron laser;Genes;Genetic Transcription;Hydrolysis;In Vitro;Individual;insight;Ions;Knowledge;Lasers;Life;Mediating;Messenger RNA;Metals;Methodology;millisecond;Modeling;Molecular;Molecular Conformation;Molecular Evolution;Motion;movie;mutant;Nature;Nucleotides;Organism;particle;Peptide Initiation Factors;Physiologic pulse;Play;Polymerase;Positioning Attribute;Process;Publishing;Radiation induced damage;Reaction;Regulation;Resolution;RNA;RNA chemical synthesis;RNA Polymerase II;Roentgen Rays;Role;scaffold;Seminal;Site;Sodium Chloride;Specific qualifier value;Structure;System;technological innovation;Technology;technology development;Temperature;Time;time interval;time use;Transcription Elongation;transcription factor;Transcription Initiation;Transcription Process;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Studies of RNA Polymerase II Transcription Initiation and Elongation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Nutrition;Prevention;Vector-Borne Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: This research is relevant to public health because of its conceptual novelty and its broad impact on chemosensory research. It is proposed to examine the molecular and cellular basis of a novel taste modality in Drosophila larvae, the taste of RNA and ribonucleosides, which are essential nutrients during the fast- growing larval life stages. The taste of RNA is conserved across a range of insect species, including disease transmitting mosquitoes, and therefore, elucidating the mechanism of this taste modality may lead to new approaches and strategies for insect pest control.

PI_NAMEs: AMREIN, HUBERT O (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adult;Agriculture;Animals;Arthropods;Behavior;Behavioral;Biology;Biomass;Carbohydrates;Cells;Characteristics;Chemicals;Chemoreceptors;Classification;Consumption;Culicidae;Dengue;Desire for food;Detection;dietary;disease transmission;Disease Vectors;Drosophila genus;Drosophila melanogaster;Ecosystem;Famines;Fatty acid glycerol esters;fitness;Flour;fly;Food;Fructose;Fruit;Gene Family;Genes;Genome;Grant;Grasshoppers;Growth;hatching;Health;Homologous Gene;Hour;Human;human disease;Image;Insect Vectors;Insecta;insight;interest;Isoptera;Larva;Life;Ligands;Light;Macronutrients Nutrition;Malaria;Mammals;Mediating;Microbe;Modality;Molecular;Names;Neurons;novel;novel strategies;Nutrient;Order Coleoptera;Pathway interactions;Persons;Pest Control;Phase;Plants;Population Control;Productivity;Property;Proteins;Public Health;rapid growth;receptor;receptor function;Receptor Gene;Research;Research Personnel;Resources;Ribonucleosides;Ribose;RNA;Role;sensor;Sensory;sensory system;Source;Structure-Activity Relationship;sugar;System;Taste Buds;Taste Perception;taste system;Temperature;Temperature Sense;Time;tool;Treatment Cost;vanilloid receptor subtype 1;Vertebrates;Work;Yellow Fever;ZIKA

PROJECT_TITLE: The taste of ribonucleosides: The molecular and cellular basis underlying chemosensory detection of previously unknown macronutrients

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project narrative: Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection in the U.S.; consequences of untreated CT infections include pelvic inflammatory disease, ectopic pregnancy, as well as increased healthcare costs. We seek to assess how the vaginal microbiome, characteristics of the infecting CT organism, and immune responses affect spontaneous clearance of CT (without antibiotics). This proposal is in response to PA-19-096 (“Control of Sexually Transmitted Infections (STIs) Through a Comprehensive Understanding of the Natural History of Infection”) and is fully responsive to the program announcement's objective and NIH mission of identifying biological and clinical factors that influence spontaneous clearance of a STI in order to support the development of novel interventions such as live biotherapeutics drugs and vaccines.

PI_NAMEs: BROTMAN, REBECCA M. (contact);RAVEL, JACQUES

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adjuvant;Affect;Age;Animals;Anti-Inflammatory Agents;antibiotic design;Antibiotic Therapy;Antibiotics;Archives;Bacteria;Bacterial Vaginosis;Behavioral;Biogenic Amines;Biological;Biological Response Modifier Therapy;Cell Adhesion;cervicovaginal;cervicovaginal microbiome;Characteristics;Chlamydia;Chlamydia trachomatis;chronic pelvic pain;cis-female;Clinical;clinically relevant;cohort;confirmatory trial;Costs and Benefits;Data;Development;dimension reduction;Ectopic Pregnancy;enhancing factor;Epidemiology;epidemiology study;Equilibrium;Event;experience;follow-up;Formulation;Future;Genes;Genitalia;Guidelines;guinea pig model;Health Care Costs;high dimensionality;hormonal contraception;Human;human old age (65+);Immune response;Immunity;Immunologic Factors;Immunologics;immunoregulation;In Vitro;Incidence;Indoles;Infection;infection rate;infection risk;Infertility;Inflammation;inflammatory marker;Interferon Type II;Interleukin-10;Interleukin-12;Interleukin-2;Interleukin-4;Interleukin-6;Intervention;Isomerism;Kynurenine;Lactic acid;Lactobacillus;Lavage;Link;Longitudinal Studies;Lubricants;Machine Learning;major outer membrane protein;metabolome;metabolomics;Metagenomics;Methods;Mission;Modeling;Modernization;Mucosal Immunity;Mucous Membrane;multidisciplinary;Multiomic Data;Mus;Natural History;NIH Program Announcements;novel;novel strategies;Organism;Outcome;pathogen;Pathologic;Pelvic Inflammatory Disease;Personal Behavior;Pharmaceutical Preparations;prevent;Prevention strategy;Preventive;Prevotella;programs;Proliferating;Recommendation;Recording of previous events;Recurrence;Reporting;repository;Resolution;Resources;response;Risk;Role;routine Bacterial stain;sample archive;Sampling;screening;screening program;Serotyping;Sexually Transmitted Diseases;Smoking;Stress;Structure;successful intervention;System;T-Lymphocyte;Techniques;Th1 Cells;Th2 Cells;Tryptophan;United States National Institutes of Health;Vaccine Research;vaccine trial;Vaccines;Vagina;vaginal microbiome;vaginal microbiota;Visit;Woman;Work;young woman

PROJECT_TITLE: Cervicovaginal microbiome, mucosal immunity, and pathogen factors that contribute to spontaneous clearance of Chlamydia trachomatis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(90)]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: In order to better understand how HIV affects the brain in the era of combination antiretroviral therapy, and in order to improve current treatment options, we will study the cell susceptible to HIV infection--human microglia--, in the mouse brain. This includes novel experimental therapies of antiretrovirals combined with Cannabinoid receptor-specific drugs that could lower the extent of inflammation and infection in the brain.

PI_NAMEs: AKBARIAN, SCHAHRAM  (contact);CHEN, BENJAMIN K;SWARTZ, TALIA H

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;addiction;Affect;Agonist;Anti-Inflammatory Agents;Antiinflammatory Effect;antiretroviral therapy;Autopsy;Award;Behavior;Biological Models;Brain;cannabinoid receptor;CD34 gene;CD8B1 gene;cell type;Cells;Chromatin;CNR1 gene;CNR2 gene;Cocaine Abuse;Cognition;cognitive function;Combined Modality Therapy;Complement;Data;Diagnosis;Disease;DsRed;Encephalitis;Enterobacteria phage P1 Cre recombinase;Epidemic;epigenome;epigenomics;Funding;Gene Expression;Genes;Genetic Recombination;Genome;genomic profiling;Genomics;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hi-C;High Prevalence;HIV;HIV encephalitis;HIV Genome;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;Human;human induced pluripotent stem cells;Immune system;Immunodeficient Mouse;improved;induced pluripotent stem cell;Infection;Inflammation;Injections;integration site;Intervention;Investigational Therapies;Knock-in;Laboratories;latent infection;Link;Liver;Macrophage;Macrophage Colony-Stimulating Factor;Maps;Measures;Mediating;Microglia;Modeling;Molecular Conformation;Molecular Profiling;mouse model;Mus;Neonatal;neonatal mice;neuroAIDS;Neuroanatomy;Neurobiology;neurogenomics;Neuroglia;neuroinflammation;novel;opioid abuse;Pattern;Peripheral;Persons;Pharmaceutical Preparations;Predisposition;preference;Primary Cell Cultures;reconstitution;Regimen;Reporter;Rewards;RNA;Site;Sorting;Specimen;Stem cell transplant;Substance Use Disorder;Switch Genes;System;Technology;Testing;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Treatment Protocols;Umbilical Cord Blood;Variant;Viral;Work

PROJECT_TITLE: Modeling HIV Microglia-Associated Infection and Inflammation in a Chimeric Mouse Brain


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative RNA molecules are vital to many cellular functions in biology. Telomerase RNA is a class of long noncoding RNA (lncRNA) that plays an essential role in telomerase function, telomere maintenance, and chromosome stability. This research program aims to understand an unprecedented mRNA-derived biogenesis pathway of telomerase RNA in a fungal model organism, which will provide unforeseen insights into how mRNA may be processed to generate lncRNA and have broad impacts on RNA biology and human diseases.

PI_NAMEs: CHEN, JULIAN J-L (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3' Untranslated Regions;Alternative Splicing;Amino Acid Sequence;Animals;Ascomycota;Basidiomycota;Binding Proteins;Biogenesis;Biology;cancer cell;Cell Physiology;Chromosomal Stability;Code;Complex;CRISPR/Cas technology;DNA;Enzymes;Eukaryota;Evolution;Family;fungus;Genes;Genetic;genetic information;Genetic Transcription;Genome Stability;Goals;human disease;innovative technologies;insight;Introns;Life Cycle Stages;Mammalian Cell;Measures;Messenger RNA;model organism;Molecular;mRNA Precursor;nanopore;novel;nuclease;Nucleotides;Outcome;Pathway interactions;Pattern;Plants;Play;posttranscriptional;Process;programs;protein expression;Protein Isoforms;Proteins;Regulation;Research;Ribonucleoproteins;RNA;RNA Decay;RNA metabolism;RNA Polymerase II;RNA Polymerase III;RNA Precursors;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;sequencing platform;Small Nuclear RNA;Small Nucleolar RNA;stem cells;Structure;Technology;Telomerase;Telomerase RNA Component;Telomere Maintenance;tool;Transcript;Untranslated RNA;Ustilago;Yeasts

PROJECT_TITLE: Biogenesis of mRNA-derived telomerase long noncoding RNA

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Copy number variations (CNVs) are a significant source for diseases in the human population, including cancer and autism. The cellular mechanisms that contribute to CNV formation and their phenotypic consequences are not well understood, particularly in disease-relevant diploid genomes that have higher structural plasticity than conventional haploid model systems. Our research will contribute to a broad investigation of fundamental CNV mechanisms in diploid yeast cells, thus opening an avenue for uncovering risk factors that may lead to CNV formation in humans.

PI_NAMEs: ARGUESO, JUAN LUCAS  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Aneuploidy;autism spectrum disorder;Biological Assay;Biological Models;Biology;Cells;Chromosomal Rearrangement;Chromosomes;Complex;Copy Number Polymorphism;Creativeness;Custom;Development;Diploidy;Disease;Evolution;Funding;Gene Dosage;Generations;Genetic Polymorphism;Genetic Variation;Genome;Genomic Instability;genomic variation;Genomics;Haploidy;Health;Heterozygote;Homologous Gene;Human;Human Genome;insight;Investigation;Laboratories;Life;Loss of Heterozygosity;Malignant Neoplasms;Measures;Meiosis;Mentors;Mitotic;Mutagenesis;Organism;Phenotype;Population;prevent;Process;Property;Reiterated Genes;repaired;Reporting;Research;Risk Factors;Saccharomyces cerevisiae;Saccharomycetales;Scientist;Source;Structure;Surveys;Talents;Time;tool;Training;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanisms and Phenotypic Consequences of Structural Genomic Variation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Lymphatic Research;Nutrition;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative This NRSA F30 fellowship will provide an invaluable training opportunity for a future physician scientist as she develops into an emerging leader in immunology related research. The proposed studies will investigate the role of lymph contents from alcohol-treated animals in PLAT fTreg expansion and subsequent immune and metabolic dysregulation. Findings from this study will further our understanding of the negative consequences of alcohol-associated lymph leakage and how its constituents impact PLAT immune cell milieu, specifically fTregs, contributing to development of PLAT IR and potentially systemic IR.

PI_NAMEs: WEAVER, KOURTNEY D (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: adaptive immunity;adipokines;Adipose tissue;Adult;Age;age related;alcohol comorbidity;alcohol consequences;alcohol content;alcohol effect;Alcohols;Animal Feed;Animals;Antigen-Presenting Cells;Antigens;binge drinking;Biochemical;blood glucose regulation;career;career development;Cause of Death;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Separation;Cells;Chronic;chronic alcohol ingestion;Coculture Techniques;Consumption;Control Animal;Data;Dendritic Cells;Development;Diet;dietary control;Ensure;Environment;Event;Extravasation;Fatty acid glycerol esters;Fellowship;FOXP3 gene;Future;Gastrointestinal tract structure;Glucose;glucose uptake;Heavy Drinking;Histologic;Homeostasis;Immune;Immune system;Immunology;Inflammation;inflammatory milieu;insight;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Interleukin-2;Interleukin-6;Lamina Propria;Life Style;lipid metabolism;Liver;Lymph;Lymphatic;Lymphatic System;lymphatic vessel;macromolecule;Measures;Medical;Medicine;Mentors;mesenteric lymph node;mesenteric lymphatics;Metabolic;Metabolism;Modeling;Mucous Membrane;National Research Service Awards;Natural Immunity;Nonesterified Fatty Acids;OGTT;old mice;Pathway interactions;Physicians;Play;Population;Process;Publishing;Rattus;receptor;Regulatory T-Lymphocyte;Reporting;Research;response;Role;Scientist;Signal Pathway;Signal Transduction;Stromal Cells;success;T-Lymphocyte;Techniques;Testing;Tissue Banks;Tissues;Tobacco;Training;training opportunity;Triglycerides;Unhealthy Diet;United States;Visceral;Work

PROJECT_TITLE: Immunometabolic consequences of alcohol-induced mesenteric lymphatic dyshomeostasis


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Pro-inflammatory T cell responses in the central nervous system are causally associated with multiple demyelinating and neurodegenerative diseases, including Multiple Sclerosis, Parkinson's Disease, Alzheimer's Disease and age-associated cognitive decline, which collectively affect over 7 million Americans and requires annual health care costs approaching one trillion dollars. The focus of this proposal is to define the role and regulation of a novel pathway that critically controls T cells in neuroinflammation, and determine its therapeutic potential to limit disease.

PI_NAMEs: SONNENBERG, GREGORY F (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adaptive immunity;Address;Affect;Age-associated memory impairment;Alzheimer's Disease;American;Amyotrophic Lateral Sclerosis;Antigen Presentation;Antigen Targeting;Autoimmune;B-Lymphocytes;CD4 Positive T Lymphocytes;cell growth regulation;Cell Maturation;cell type;Cells;Central Nervous System;Circulation;Clinical;Clinical Research;Coculture Techniques;Critical Pathways;curative treatments;cytokine;Cytokine Receptors;Data;Demyelinating Diseases;Dendritic Cells;Disease;Exhibits;Experimental Models;Family;Gene Expression Profile;gut inflammation;Health Care Costs;Histocompatibility Antigens Class II;Homing;IL17 gene;Immunity;immunoregulation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Innate Immune System;innovation;Intestines;Knowledge;Lymphocyte;Lymphoid Cell;Mediating;mouse model;mucosal site;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Neurodegenerative Disorders;neuroinflammation;next generation;novel;novel strategies;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peripheral;Population;prevent;Production;progenitor;receptor;Regulation;Research Proposals;response;Role;Sampling;Specific qualifier value;T cell infiltration;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;transcription factor;Translating;translational study;treatment strategy

PROJECT_TITLE: Innate immune regulation of neuroinflammation


ORG_CITY: BINGHAMTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques that do not require extensive antibody engineering efforts. The goal of this proposal is to optimize and demonstrate the utility of a new site- specific conjugation technology that places payloads within a conserved hydrophobic pocket of IgG antibodies. We will demonstrate the broad utility of this method through the preparation and evaluation of antibody conjugates for oncology, immunology, and imaging applications.

PI_NAMEs: TUMEY, LAWRENCE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Achievement;Amines;Antibodies;antibody conjugate;antibody engineering;Antibody-drug conjugates;arm;Autoimmune Diseases;B-Cell Lymphomas;B-Lymphocytes;biophysical properties;Biophysics;cancer therapy;career;Catabolism;Cells;chemical property;Chemicals;clinically relevant;Communities;Complex Mixtures;Cysteine;Data;Dependence;design;Development;Drug Delivery Systems;Drug Industry;Drug Kinetics;Environment;Enzymes;Esters;Evaluation;Exhibits;FDA approved;fluorescence imaging;functional group;Goals;Head;Human;Hydrophobicity;IgG1;Image;imaging probe;Imaging Techniques;Immunoglobulin G;Immunology;Immunosuppressive Agents;improved;In Vitro;in vivo;insight;interest;Link;live cell imaging;Location;Lysine;Lysosomes;Mediating;Membrane Proteins;Metabolic;Metabolism;Methods;microbial;Microscopy;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;Mus;next generation;Oncology;Outcome;Pharmaceutical Preparations;Pharmacy Schools;Plasma;Positioning Attribute;Preparation;prevent;Process;programs;Property;Protein Engineering;Publishing;Raman Spectrum Analysis;Reporting;Research;rituximab;Safety;Site;Structure;Techniques;Technology;Therapeutic;Time;Tissue imaging;Tissues;tool;trafficking;Trastuzumab;uptake;Xenograft Model

PROJECT_TITLE: Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative HLA-F is a nonclassical MHC class I molecule that likely plays a role in cancer, HIV infection, autoimmunity and reproduction. It was previously thought to exist only as a heavy chain, without association with the 2microglobulin (2m) subunit or bound peptide. We have recently shown that HLA-F can associate with both 2m and peptide, these two states of HLA-F confer differing reactivity to receptors expressed on effector cells. The goal of this proposal is to understand, at the molecular and functional levels, how HLA-F engages with these receptors.

PI_NAMEs: ADAMS, ERIN JUNE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Address;Adenoviruses;Adopted;Amino Acids;Antibodies;Antigens;Applications Grants;Area;Autoimmune Diseases of the Nervous System;Autoimmunity;Binding;Biological Assay;biophysical analysis;Biophysics;cancer cell;Cell surface;cell type;Cells;Clone Cells;conformer;Data;Decidua;Disease;Effector Cell;Environment;Family;Family member;fetal;Funding;Genetic Polymorphism;Goals;Health;HIV;HIV Infections;Homeostasis;Human;Immune;Immunity;immunoregulation;Infection;Invaded;Investigation;KLRD1 gene;Length;Ligands;Link;Major Histocompatibility Complex;Malignant Neoplasms;member;Methods;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Natural Killer Cells;pathogen;Peptides;Play;Post-Translational Protein Processing;Pregnancy;Production;protein complex;Protein Isoforms;Proteins;Publishing;Reagent;receptor;Receptor Cell;Recombinants;Reproduction;RNA Splicing;Role;Source;Specificity;Structure;T-Lymphocyte;Testing;three dimensional structure;trafficking;tumor;Variant;Viral;Work

PROJECT_TITLE: Molecular and functional investigation of the role of HLA-F in immune regulation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


PHR: Project Narrative The maintenance of quiescent cell populations in the body is essential to repair wounds, maintain healthy tissue and for pathogen defense, and once cells enter quiescence, they must also be able to re-enter the cell cycle and divide again. This project will investigate multifaceted cellular pathways regulated by E2F and APC/CCdh1 activity and how they synergize to create two pathways into S phase that must be suppressed to allow cells to enter quiescence, and how this synergy allows for the licensing of origins of DNA replication in G1. Completion of this study in single cells will support the identification of potential treatment targets for quiescent cancer cell populations and pro-proliferative treatments for increased cellular regeneration.

PI_NAMEs: UPADHYA, SAMSARA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Binding;Biological;cancer cell;CCNE1 gene;CDC2 gene;CDC7 gene;CDK2 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Differentiation process;Cell division;Cell Proliferation;cell regeneration;Cells;Cellular biology;chemotherapy;Chromatin;Cyclin A;Data;Decision Making;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA replication origin;Ensure;Equilibrium;G1 Phase;Genes;Genetic;Genetic Transcription;GMNN gene;Goals;Growth;helicase;Heterogeneity;Human;human embryonic stem cell;Immunofluorescence Immunologic;inhibitor;insight;Knowledge;Learning;Licensing;live cell imaging;loss of function;Maintenance;Malignant Neoplasms;Mammals;Measures;Methods;Mitosis;Modeling;Molecular;Monitor;novel;pathogen;Pathway interactions;pharmacologic;Phosphotransferases;Population;Positioning Attribute;premature;prevent;programs;Proliferating;Proteins;Regulation;Regulatory Pathway;Replication Initiation;Replication Origin;Reporter;Research Personnel;Resolution;Role;S phase;Signal Pathway;Signal Transduction;single cell analysis;small molecule;Stains;stem cell differentiation;synergism;targeted treatment;Testing;Time;tissue regeneration;tissue repair;Tissues;ubiquitin-protein ligase;Work;wound healing

PROJECT_TITLE: Single-cell dynamics of E2F and APC/CCdh1 coordination that regulate the proliferation-quiescence decision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Racial and ethnic disparities in health care services cause many Non-Hispanic Black and Hispanic children with autism spectrum disorder (ASD) symptomology to go undiagnosed and under-represented in research studies generated from those clinical databases. Yet, many epidemiologic studies use healthcare databases to examine etiologic questions about ASD, often without necessary consideration of potential biases. Thus, this project will use quantitative bias analysis methods to examine the impact of information and selection bias in ASD research, with an application to the association between epidural analgesia use and ASD.

PI_NAMEs: INGOL, TANIQUA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Accidental Injury;Accounting;administrative database;Algorithms;anti-racism;autism spectrum disorder;autistic children;barrier to care;Birth Certificates;Black race;Caregivers;Case/Control Studies;Child;Child Development;Childbirth;Classification;Clinical assessments;clinical database;clinical diagnosis;Code;Consultations;Country;Data;Databases;design;Development;Diagnosis;Early Diagnosis;Early Intervention;Epidemiologic Methods;epidemiology study;Epidural Analgesia;Equity;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Etiology;Evaluation;experience;Fellowship;Foundations;Future;Goals;Grant;hazard;Health;health care availability;health care disparity;health care service;health care service utilization;health inequalities;Healthcare;Healthcare Systems;Hispanic;improved;individuals with autism spectrum disorder;Information Dissemination;Interview;Life Cycle Stages;Literature;Maternal and Child Health;Medical Records;Mental disorders;Mentorship;Metabolic syndrome;Methods;Monte Carlo Method;Mothers;multidisciplinary;Not Hispanic or Latino;novel;Outcome;Predictive Value;professor;Public Health Practice;Quality of life;Race;racial discrimination;racial disparity;racial minority;Racial Segregation;Registries;Reporting;Research;research study;responsible research conduct;Risk;Risk Factors;Selection Bias;service intervention;Services;simulation;Site;skills;Sleep Disorders;Solid;Structural Racism;systemic barrier;tenure track;Training;United States;Validation;Work;Writing

PROJECT_TITLE: Accounting for selection and information bias in studies of Autism Spectrum Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Human Genome;Lung;Patient Safety;Precision Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Public Health Relevancy This proposed research will establish the molecular mechanisms underlying the response to inhaled corticosteroids and adrenal suppression, a potentially severe adverse effect of corticosteroid therapy, in asthma patients. This proposal has the potential to generate a significant clinical impact through the identification of asthma patients who would either benefit from switching to alternative treatment(s), or who may require more intensive monitoring of adrenal function to avoid adrenal suppression. Ultimately, this research has the promise to revolutionize asthma treatment, help to offset the mounting costs of asthma management, and improve outcomes for patients.

PI_NAMEs: DAHLIN, AMBER  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Adrenal gland hypofunction;Adrenal Glands;Adverse effects;Adverse event;alternative treatment;Amber;Asthma;asthma exacerbation;asthmatic;asthmatic patient;Automobile Driving;Bayesian Network;biobank;Bioinformatics;Biological;Caring;Chronic Disease;Clinical;Clinical Trials;Complex;Computer Models;Consensus;Corticotropin;cost;Data;Diagnostic tests;Disease;Doctor of Philosophy;Dose;Drug Exposure;Drug Prescriptions;economic value;Emergency department visit;experience;Functional disorder;Future;General Population;Genes;Genetic;genome wide association study;Genomics;Goals;Guidelines;Health Care Costs;Healthcare Systems;Hospitalization;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;improved outcome;Individual;individualized medicine;Inhalation;innovation;insight;inter-individual variation;Knowledge;Laboratories;Light;Link;Lung;metabolomics;Methods;Molecular;molecular marker;Monitor;Multiomic Data;network models;novel;Organ;Pathway interactions;Patient risk;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Plasma;Population;precision medicine;Prediction of Response to Therapy;prevent;Production;prospective;Public Health;Publications;Recommendation;repository;Research;research clinical testing;Resistance;responders and non-responders;response;Risk;Risk Reduction;Role;Sampling;Severities;side effect;Steroid Resistance;Steroids;symptom management;Symptoms;Systems Biology;Testing;Translational Research;Treatment outcome;Treatment Protocols;treatment response;Urine;Work

PROJECT_TITLE: Pharmacogenomics of Adrenal Suppression with Inhaled Corticosteroids (PhASIC)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Brain metastasis (BM) frequently arises from non-small cell lung cancer (NSCLC) and represents the most common cause of cancer related death in the US, yet our understanding of BM biology is rudimentary. Our group has identified excessive chromosomal instability (CIN) as a hallmark of BM and as a putative characteristic of NSCLCs harboring mutation in STK11 (encoding LKB1), a subtype of lung cancer associated with increased risk of brain metastasis (BM) and immunotherapy resistance, and thus a relevant archetypical disease that may broadly inform the role of CIN in BM biology. This proposal seeks to identify tumor-cell intrinsic and extrinsic adaptations to CIN that enables immune evasion and BM in LKB1-deficient NSCLCs; because CIN is pervasive in cancer and particularly high in brain-metastatic lesions across different cancer types, this work will have implications for our broader understanding of BM biology and pave the way for future therapeutic development of CINhigh tumors.

PI_NAMEs: CAPRIO, LINDSAY ANNE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adenosine;Behavior;Biology;blood-brain barrier permeabilization;Brain;Cancer Biology;cancer cell;Cancer Etiology;Cancer Patient;cancer type;career;Cell Line;Cells;Cephalic;Cessation of life;Characteristics;Chromosomal Instability;Chromosome Arm;chromosome loss;Chromosome Segregation;Chronic;combinatorial;Coupled;CRISPR/Cas technology;Cytosol;Data Set;Databases;Development;Disease;DNA;Drug resistance;ds-DNA;ecto-nucleotidase;Environment;Evolution;experimental study;Failure;Future;Generations;Genetic;Genetic Engineering;GENIE;genome sequencing;genomic data;Goals;Human;Image;immune checkpoint blockade;Immune Evasion;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In Situ;In Vitro;in vivo;Injections;Interferon Type I;Investigation;KRASG12D;Label;Link;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;Melanoma;Mentors;Metastatic malignant neoplasm to brain;Methods;micronucleus;Mitosis;Modeling;Molecular;mouse model;multimodality;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;NF-kappa B;Non-Small-Cell Lung Carcinoma;Output;Pathway interactions;Phosphotransferases;Physicians;Primary Neoplasm;Process;Production;Proteins;Recycling;refractory cancer;Research;Resistance;response;Risk;Role;Rupture;Scientist;Signal Transduction;spatiotemporal;Stimulator of Interferon Genes;STK11 gene;Surface;System;Tail;Testing;The Cancer Genome Atlas;therapeutic development;Tissues;TP53 gene;transcriptomics;tumor;tumor behavior;Tumor Escape;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Subtype;tumor-immune system interactions;Universities;Up-Regulation;Validation;Veins;Work

PROJECT_TITLE: Chromosomal instability as a driver of non-small cell lung cancer immune evasion and brain metastasis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Duchenne muscular dystrophy (DMD)—one of the most common and severe genetic muscle disorders—is characterized by progressive muscle weakness. This proposal seeks to develop a safe, flexible, muscle-specific gene editing strategy that improves muscle strength by encouraging cells to ignore DMD-causing gene mutations. Completing this work will inform the development of a one-time treatment for DMD, and potentially other genetic muscle diseases.

PI_NAMEs: KRAUS, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3' Untranslated Regions;5 year old;Ablation;Address;adeno-associated viral vector;adenovirus mediated delivery;Adrenal Cortex Hormones;Affect;Antisense Oligonucleotide Therapy;Bioinformatics;Cardiac Myocytes;Cell Line;Cell model;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Consensus Sequence;CRISPR/Cas technology;Dependovirus;design;Development;Duchenne muscular dystrophy;Dystrophin;Epithelial Cells;exon skipping;Exons;FDA approved;flexibility;Gene Mutation;gene-editing approach;Genetic;Genus staphylococcus;Guide RNA;Health;Heart;improved;in vivo;Infusion procedures;Inherited;inhibitor;Liver;Lung;Measures;Mediating;Messenger RNA;MicroRNAs;Modeling;Mouse Cell Line;mouse model;Mus;Muscle;Muscle Cells;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;muscular dystrophy mouse model;Mutation;Myoblasts;Myopathy;Neisseria meningitidis;nuclease;Orthologous Gene;Other Genetics;Patients;Plasmids;postnatal;promoter;Proteins;Reading Frames;Repression;respiratory;Risk;RNA Splicing;Safety;side effect;Site;Specificity;Symptoms;System;Testing;Therapeutic;tissue tropism;Tissues;tool;vector;Wild Type Mouse;Work

PROJECT_TITLE: Muscle-Specific CRISPR/Cas9 Exon Skipping for Duchenne Muscular Dystrophy Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Membrane receptors are important therapeutic targets for many diseases and are expressed throughout the body. Understanding the role of receptor assembly in the complex environment of a live animal is an important step in understanding their mechanism of activation and regulation. We will develop ex vivo single-molecule methods that for the first time will enable quantitative studies of stoichiometry for receptors extracted from mice.

PI_NAMEs: RICHARDS, CHRISTOPHER I (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Animal Communication;Animal Disease Models;Animal Model;animal tissue;Animals;Biological;Biological Models;Brain;Brain region;Cardiac;Cell Culture Techniques;cell type;Cells;Chemicals;Classification;cluster computing;Communication;Complex;Consumption;convolutional neural network;Data;Data Analyses;Data Set;design;Development;Dimerization;Disease;Encapsulated;Environment;Exposure to;Future;Genes;Goals;Heart;High Performance Computing;Image;imaging capabilities;In Vitro;in vivo;insight;Knock-in;Knock-in Mouse;large datasets;Machine Learning;Manuals;Measurement;Mediating;Membrane;Membrane Proteins;Methodology;Methods;molecular imaging;Monitor;Mus;nanoscale;nanovesicle;novel;open source;Organ;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiological Processes;Play;Population;postsynaptic neurons;Preparation;presynaptic;Process;Process Measure;Property;Protein Biosynthesis;Protein Dynamics;protein purification;Proteins;prototype;receptor;Regulation;Research;Research Methodology;Research Personnel;response;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Sampling;sex as a biological variable;Signal Transduction;single molecule;stoichiometry;System;technique development;Techniques;Technology;Testing;Therapeutic;therapeutic target;Time;tissue preparation;Tissues;tool;trafficking;Training;Vesicle

PROJECT_TITLE: Ex vivo single molecule tools to analyze membrane receptor dynamics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Multiple Sclerosis;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Sleep Research;Therapeutic Cannabinoid Research

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Cannabidiol (CBD) is a promising, complimentary treatment for pain, particularly for patients with chronic neurological conditions such as multiple sclerosis (MS), but research that increases our understanding of analgesic mechanisms of CBD is sorely needed to maximize its benefits. Sleep shares a close bidirectional relationship with pain, and may be a key mediator in the analgesic effects of CBD. The proposed research will study the effects of CBD on sleep in persons with MS and chronic pain, and explore changes in sleep as a mediator of the analgesic effects of CBD.

PI_NAMEs: BRALEY, TIFFANY JOY (contact);KRATZ, ANNA LOUISE

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;abuse liability;actigraphy;Affect;Aftercare;American;Analgesics;Autoimmune Diseases;Cannabidiol;Cannabinoids;Cannabis sativa plant;Central Nervous System;Chronic;chronic pain;chronic pain management;CNS autoimmune disease;Combined Modality Therapy;conventional therapy;Coupled;Data;Development;Dronabinol;Electroencephalography;Entropy;Epidiolex;Exhibits;experience;Formulation;Frequencies;Goals;Heart;Home;improved;improvement on sleep;Individual;innovation;insight;Intervention;Investigation;Knowledge;Length;Measures;Mediator;Methods;Modeling;Multiple Sclerosis;multiple sclerosis patient;National Center for Complementary and Integrative Health;Neurologic;non rapid eye movement;novel;Numeric Rating Scale;outcome disparities;Pain;Pain intensity;Pain management;Pain Measurement;pain processing;painful neuropathy;Patient Self-Report;Patients;Periodicity;Persons;Phenotype;placebo group;Placebos;Play;Polysomnography;Population;Positioning Attribute;precision medicine;Probability;Randomized;REM Sleep;Research;Research Personnel;Respondent;response;Role;sensory system;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep onset;sleep pattern;sleep physiology;Sleep Stages;Structure;Surveys;Techniques;Tetrahydrocannabinol;Therapeutic;Time;treatment group;Wrist

PROJECT_TITLE: Mechanisms of cannabidiol in persons with MS: the role of sleep and pain phenotype

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Sustained immunosuppression due to lymphocyte cell death and dysfunction exacerbates sepsis-induced mortality. Based on my preliminary results, I aim to study the role and mechanism of an immune inhibitory molecule, SUSD2, in promoting T lymphocyte cell death and dysfunction during microbial sepsis. Understanding the function of SUSD2 in sepsis-induced immunosuppression will be instrumental for the generation of new strategy targeting the prevention and/or treatment of this complex syndrome.

PI_NAMEs: WEN, HAITAO  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;activating transcription factor;Animals;anti-PD1 antibodies;Antibodies;Antibody Therapy;Apoptosis;Attenuated;Automobile Driving;Biochemical;Biological Assay;bZIP Domain;Cancer Model;Cause of Death;cecal ligation puncture;Cell Death;Cell Death Induction;Cell Physiology;Cell Separation;Cell surface;Cell Survival;Cells;Clinical;Clinical Research;Complex;Development;Disease;Disease Outcome;early phase clinical trial;effector T cell;experimental study;Functional disorder;Generations;Genes;Genetic;Goals;Healthcare Systems;Immune;immune checkpoint blockade;Immune response;Immune Targeting;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;insight;Intensive Care;Intensive Care Units;Interleukin 2 Receptor;Interleukin-2;Life;loss of function;Lymphocyte;Maps;Mechanical Ventilators;Mediating;microbial;mitochondrial fitness;Modeling;mortality;Mus;new therapeutic target;novel strategies;Organ;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;polymicrobial sepsis;Prevention;Proteins;Receptor Signaling;Regimen;Repression;restoration;Role;Sepsis;septic;septic patients;Signal Transduction;single molecule;single-cell RNA sequencing;STAT protein;Sushi Domain;Syndrome;T cell response;T cell therapy;T-Lymphocyte;Technology;Testing;Therapeutic;transcription factor;Translating;Trauma;tumor

PROJECT_TITLE: Targeting immune inhibitory molecule SUSD2 to reverse immunosuppression

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative Macroautophagy and methionine sulfoxide reductases (Msrs) are two important pathways for degrading and repairing damaged proteins, and their impairments have been associated with a number of neurodegenerative disorders. Here, we will investigate the role of macroautophagy and Msrs in maintaining cellular homeostasis within cells. Our results will provide important insights into the mechanism by which these two important pathways select specific proteins for degradation or repair.

PI_NAMEs: GHAEMMAGHAMI, SINA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TITLE: Global analysis of the selectivity of proteostatic pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: BEIRUT

ORG_COUNTRY: LEBANON

ORG_FIPS: LE

ORG_NAME: AMERICAN UNIVERSITY OF BEIRUT

PHR: Non-Communicable Diseases (NCD) continue to dominate as a major cause of Health-related morbidity, chronic disabilities, and mortality, exceeding 50% worldwide; the Middle East and North Africa region are no exception. The Scholars in HeAlth Research Program is an interfaculty collaborative initiative that provides short, intermediate, and long-term training, to health professionals engaged in population- based and clinical translational NCD research. Its multidisciplinary and cross-cutting approach integrates a solid curriculum in quantitative skills, advances in science and technology, hands-on applied training, thus providing the basis for effective public heath interventions to promote Health across the life course.

PI_NAMEs: FULEIHAN, GHADA ELHAJJ (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;American;Career Mobility;certificate program;cohort;Competence;Complement;Data Science;Disease;Doctor's Degree;Educational Curriculum;Educational process of instructing;Enrollment;expectation;experience;Faculty;Fellowship;Funding Mechanisms;Gender;Goals;Grant;Health;Health Priorities;Health system;Information Technology;Institution;Interdisciplinary Study;interest;K-Series Research Career Programs;Lebanon;Medical;Mentors;Mentorship;Methods;Mission;multidisciplinary;Outcome;Positioning Attribute;Postdoctoral Fellow;Productivity;Program Evaluation;programs;Progress Reports;Publications;Research;Research Methodology;Research Personnel;Research Training;Running;Scholars Program;Secure;Site;Solid;Source;summer program;Surveys;tool;Training;Training Programs;Universities;Writing

PROJECT_TITLE: Expanding Capacity Building in Non-Communicable Diseases: The Scholars in HeAlth Research Program (SHARP) at the American University in Beirut


NIH_SPENDING_CATS: Biotechnology;Orphan Drug;Rare Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative This proposal will collect a wide range of observations using human tissue and a class of receptors purified from human tissue that function in the immune system to fight infection. We will compare tissue from healthy donors and from patients with sickle cell disease, neuromyelitis optica, and myasthenia gravis. Preliminary data indicates a wide variety of modifications may impact receptor, and thus immune, function.

PI_NAMEs: BARB, ADAM WESLEY (contact);MACE, EMILY MARGARET

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affinity;Amino Acid Receptors;Amino Acids;Antibodies;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Asparagine;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Basophils;Binding;Blood Platelets;Carbohydrates;Cell Cycle Kinetics;cell killing;Cell Physiology;Cell surface;cell type;Cells;Clinical;Communities;Cultured Cells;cytotoxic;cytotoxicity;Data;design;Development;Diffusion;Disease;Effector Cell;Exclusion;experimental study;Fc Receptor;FCGR2B gene;fighting;glycosylation;Human;Human body;human tissue;IgG Receptors;Immune;immune activation;Immune response;Immune system;immune system function;Immunoglobulin G;immunological synapse;In Vitro;Individual;Infection;Inflammation;Inflammatory;Intervention;Kinetics;Lateral;Leukocytes;Link;Location;Macrophage;Malignant Neoplasms;Measurement;Measures;Mediating;Modification;molecular scale;monocyte;Motion;multiple data sources;Myasthenia Gravis;Myristica fragrans;Natural Killer Cells;Neuromyelitis Optica;neutrophil;new therapeutic target;novel;pathogen;Patients;Phase;Polysaccharides;Population;Post-Translational Protein Processing;Prevalence;receptor;Research Personnel;Resolution;response;Role;Sampling;Sickle Cell Anemia;Site;Stress;Structure;superresolution microscopy;Surface;synaptogenesis;Techniques;Therapeutic Monoclonal Antibodies;therapeutic target;Time;Tissues;vaccine-induced antibodies;Vaccines;Visualization

PROJECT_TITLE: Composition and structure of antibody receptors at the surface of primary human cells during immune activation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project narrative Our proposed research is to evaluate the effectiveness of using an existing implementation strategy infrastructure at academic centers in delivering best-practice communication interventions to increase HPV vaccination rates in rural primary care clinics. The project is relevant to public health because it aims to increase HPV vaccination rates and reduce cancer inequities in rural populations by addressing the context- specific communication needs of both rural providers and parents, especially those parents who are vaccine hesitant. The proposed research is relevant to the NCI because it aims to improve implementation of effective interventions that are responsive to behavioral and sociocultural factors in cancer prevention among rural populations, an understudied area in cancer prevention research.

PI_NAMEs: CALO, WILLIAM ALEXIS (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 17 year old;Address;Adolescent;Adoption;Age;Area;arm;Behavioral;boys;cancer prevention;care outcomes;Caring;Case Management;Clinic;Clinic Visits;Clinical;Cluster randomized trial;Communication;Community Healthcare;Community Networks;comparison control;comparison intervention;Complex;Consolidated Framework for Implementation Research;cost;Data;Decision Making;design;Dose;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;Evaluation;evidence base;experience;Exposure to;Family Practice;follow-up;girls;Goals;health inequalities;Healthcare;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation framework;implementation outcomes;implementation strategy;improved;Inequity;Infrastructure;innovation;Intervention;Interview;Malignant Neoplasms;men;Methods;Modeling;Monitor;Notification;Outcome;Parents;Penetration;Pennsylvania;Physicians;post intervention;President's Cancer Panel;prevent;Prevention Research;primary care clinic;primary care practice;primary care provider;primary outcome;Provider;Public Health;Randomized;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;Rural;rural America;Rural Community;rural health clinic;Rural Population;Schedule;Scientist;secondary outcome;sex;social media;sociocultural determinant;Source;Structure;Surveys;System;Testing;Time;Training;treatment arm;Use Effectiveness;Vaccination;vaccine hesitancy;Vaccines;video session;Woman;Work

PROJECT_TITLE: HPV ECHO: Increasing the adoption of evidence-based communication strategies for HPV vaccination in rural primary care practices

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The U.S. healthcare system cares for increasing numbers of older adults, including those with Alzheimer’s disease and related dementias, who require surgery with anesthesia. Regional social inequities, measured by spatial indices such as area deprivation and social vulnerability indices, independently contribute to differences in perioperative and neurodegenerative outcomes. Via the K07 mechanism and associated institutional support, the applicant will develop transdisciplinary research training and infrastructure involving geospatial data, social determinants of health, and artificial intelligence to address these challenges. This proposal will ultimately reduce disparities in postoperative outcomes in older adult surgical patients, including those with Alzheimer’s disease and related dementias, with a particular emphasis on outcomes pertaining to postoperative pain and cognitive decline.

PI_NAMEs: TIGHE, PATRICK J (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academic/Teacher Award;Acceleration;Address;Advisory Committees;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Anesthesia procedures;Anesthesiology;Anesthetics;Area;Artificial Intelligence;aspirate;Awareness;Basic Science;care systems;certificate program;Clinic;Clinical;clinical diagnosis;Clinical Sciences;Cognition;Cognitive;cognitive change;cohort;Collection;Communities;Conduction Anesthesia;curriculum development;Data;Data Linkages;data modeling;Data Science;Databases;deep learning;deprivation;Disparate;Disparity;disparity reduction;Documentation;Early Diagnosis;Electricity;electronic health record system;experience;Fellowship;Florida;Food;frailty;Funding;Geriatrics;Grant;Health;Health system;Healthcare Systems;High Performance Computing;Hospitals;Impaired cognition;indexing;Individual;Inequity;Infrastructure;Institution;Interdisciplinary Study;Investigation;Lead;Leadership;Link;Machine Learning;Measures;Medicine;meetings;Mentorship;mild cognitive impairment;Modeling;multidisciplinary;neglect;Neighborhoods;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Neuropsychology;novel;older adult;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Pain;Pathway interactions;Patients;Performance;Perioperative;Perioperative Care;Population;Population Heterogeneity;Postoperative Pain;Postoperative Period;postoperative recovery;Process;programs;prospective;provider factors;Proxy;Records;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Training;Resources;risk stratification;Role;Scientist;Secure;sex;social;social determinants;social disparities;social factors;social health determinants;Social Network;Social support;social vulnerability;Structure;success;Supplementation;surgery outcome;symposium;System;Time;timeline;Training;Training Programs;Transportation;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;unstructured data;Update;Vulnerable Populations

PROJECT_TITLE: Perioperative Cognitive Anesthesia Network Extension for Socially Vulnerable Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Infectious Diseases;Nutrition;Prevention;Tickborne Diseases;Vector-Borne Diseases

PHR: Project Narrative Alpha-gal syndrome is an allergic condition with global reach; there are reports from around the world describing these patients with delayed allergic reactions to mammalian meat, and yet, we have limited understanding of the mechanisms underlying this condition. The proposed research will explore the role of glycolipids and unconventional T cells in this allergy with the vision of broadening our understanding of their roles in hypersensitivity disorders. It may also link tick exposure to a gene expression and cytokine profile in unconventional T cells that promotes allergic responses.

PI_NAMEs: IWEALA, ONYINYE I (contact)

PROJECT_TERMS: Adult;Allergic;Allergic Reaction;allergic response;alpha-gal syndrome;Anaphylaxis;Antibodies;Antigens;Appearance;Area;Arthritis;Automobile Driving;Basic Science;Basophils;Binding;Biology;Carbohydrates;career;Cell surface;Cells;Cellular biology;Circulation;Complex;Conceptions;Consumption;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Disease;effective therapy;Effector Cell;Environment;Epithelium;Epitopes;experience;Exposure to;fatty acid metabolism;Food;food allergen;Food Hypersensitivity;Foundations;Frequencies;Funding Mechanisms;Future;galactosyl-(1-3)galactose;Gene Expression;Generations;Glycolipids;Goals;Government Agencies;Grant;Histamine;Hour;Human;Hypersensitivity;IgE;IgE Receptors;Immediate hypersensitivity;Immune;Immune response;Immunology;in vivo;Individual;Ingestion;interest;Knowledge;knowledge base;Leukotrienes;Link;lipid metabolism;Lipids;Liver;Lymphocyte;mast cell;Meat;Mediating;Mediator;medical schools;Medicine;member;Mentors;Mentorship;metabolic profile;Molecular;Mucosal Immunity;Mucous Membrane;North Carolina;novel;Oligosaccharides;Organ;Outcome;particle;Pathogenesis;Patients;Phase;Phenotype;Plasma;Population;prevent;Privatization;Process;professor;Proteins;Reaction;Reporting;Research;Research Personnel;response;Role;Running;Secondary to;Severities;Signal Transduction;skills;Skin;Surface;Symptoms;Syndrome;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;tenure track;Testing;theories;therapeutic target;Thinness;tick bite;Ticks;Tissues;Training;Translational Research;translational research program;trend;Universities;Up-Regulation;Vision

PROJECT_TITLE: A role for glycolipids and unconventional T cell subsets in alpha-gal allergy

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Perineuronal nets are complex extracellular matrix structures found exclusively surrounding a subset of neurons in the central nervous system and are established key regulators of developmental neural plasticity and cognitive functions. Despite the importance of perineuronal nets, there is little understanding of their specific functions, which is driven in large part by an incomplete understanding of their molecular composition and of the protein- protein interactions that underlie the assembly of these structures. Here, we propose to identify and undertake a structure-function analysis of the main components of perineuronal nets to understand the mechanisms that guide net formation, with the ultimate goal to identify proteins that are critical to net formation in order to design tools to manipulate these structures to promote recovery from neural injury and disease.

PI_NAMEs: BOUYAIN, SAMUEL ;MATTHEWS, RUSSELL T. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: aggrecan;Architecture;Binding;Binding Proteins;Biochemical;Biological Assay;brevican;Carbohydrates;Cell Adhesion Molecules;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Central Nervous System;Chondroitin Sulfate Proteoglycan;cognitive function;Complex;complex R;contactin;CSPG3 gene;Data;design;Development;developmental plasticity;Disease;Event;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Glycosaminoglycans;Goals;grasp;Health;Homologous Gene;Hyaluronan;In Vitro;in vivo;information processing;innovation;insight;interest;janusin;Label;Learning;Life;Ligands;Link;link protein;macromolecular assembly;Macromolecular Complexes;Memory;Methodology;Molecular;Molecular Structure;nerve injury;Nervous System Disorder;neural;neurodevelopment;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;novel;Pathogenesis;Physiological;Play;Population;protein protein interaction;Protein Tyrosine Phosphatase;Proteins;Reagent;receptor;receptor binding;receptor protein tyrosine phosphatase-type R;Recovery;response;Role;Specificity;Stimulus;Structure;Surface;Synapses;synaptogenesis;Techniques;Therapeutic;tool;versican;Work;X-Ray Crystallography

PROJECT_TITLE: The molecular architecture of perineuronal nets

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: It is crucial for human health that cells always maintain the correct concentration of proteins, as such there are various mechanisms to control protein production and degradation. The goal of this work is to understand the general principles by which protein degradation can be controlled by protein acetylation and to develop chemical tools to manipulate the acetylation status of proteins. We anticipate this will provide insights into fundamental biological processes and provide a new therapeutic approach for a variety of diseases.

PI_NAMEs: BURSLEM, GEORGE  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Acetylation;Acetyltransferase;Biochemical;Biological;Biological Process;Biology;Biophysics;Cells;Chemicals;Deacetylase;design;Disease;Enzymes;EP300 gene;experimental study;Genetic Transcription;Goals;Health;Human;insight;Molecular;molecular recognition;multicatalytic endopeptidase complex;non-histone protein;novel;novel therapeutic intervention;Pathway interactions;Phosphorylation;Post-Translational Protein Processing;Production;Protac;Protein Acetylation;Protein Databases;protein degradation;protein protein interaction;Proteins;Proteomics;proteostasis;recruit;Regulation;System;Therapeutic;tool;transcriptome sequencing;Ubiquitin;ubiquitin-protein ligase;Work

PROJECT_TITLE: Editing Acetylation and Protein Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE / RELEVANCE  A wide array of scientific disciplines (including biology, biochemistry, pharmaceutical chemistry, bioinorganic chemistry, chemical biology, and organic chemistry) make use of organic compounds, especially enantiomerically enriched compounds (due to the "handedness" of the molecules of life, e.g., peptides, DNA, RNA, and carbohydrates). The development of powerful new methods for organic synthesis, particularly enantioselective synthesis, facilitates progress in biomedical research by providing access to compounds that enable the exploration of new hypotheses and the discovery of new bioactive molecules.

PI_NAMEs: FU, GREGORY C (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Metal-Catalyzed Nucleophilic Substitution Reactions of Alkyl Electrophiles