ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Spinal cord injury is a severely debilitating event that profoundly impacts quality of life, yet there are limited effective treatment options for the patient beyond rehabilitation. The proposed research will determine how removal of the adhesion receptor, L-selectin, affects the behavior of the most abundant immune cell type (neutrophils) in the acutely injured spinal cord and subsequent long-term recovery. This work will elucidate the role of neutrophils in acute tissue damage, determine how L-selectin regulates neutrophil behavior, and advance a novel therapeutic strategy that enhances L-selectin removal from the surface of neutrophils.

PI_NAMEs: MCCREEDY, DYLAN A. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;adhesion receptor;Adhesions;Affect;Antibodies;Attenuated;Behavior;Binding;Blood;cell type;Cells;central nervous system injury;Chemosensitization;Clinical;clinically relevant;Contusions;cytotoxic;Diclofenac;Disease;effective therapy;Environment;Event;Excision;Exposure to;FDA approved;Goals;Hour;Human;Immune;improved;In Vitro;in vitro activity;in vivo;Individual;Infection;Inflammation;Inflammatory;Injury;intraperitoneal;Intravenous;intravenous administration;intravenous injection;Invaded;Knock-in Mouse;L Forms;L-Selectin;Ligand Binding;Ligands;long term recovery;Mediating;Mediator;Modeling;Mus;Myelin;Neurologic Deficit;Neurological outcome;neurological recovery;neuroprotection;neutrophil;Neutrophil Activation;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel therapeutic intervention;Pathogenicity;Patients;Phase;Play;Process;Production;Quality of life;Reactive Oxygen Species;receptor;Receptor Signaling;Recovery;Recovery of Function;recruit;Recruitment Activity;Rehabilitation therapy;Research;response;response to injury;Role;Spinal Cord;Spinal cord injury;spinal cord white matter;Surface;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;white matter;Work

PROJECT_TITLE: L-selectin shedding as a novel therapeutic strategy to mitigate acute secondary damage after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Dental, Oral, and Craniofacial Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NORMAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Narrative When someone suffers a severe brain injury, a portion of the skull must be removed so that the brain can swell. Unfortunately, a second surgery is required to replace that missing piece of the skull, and the patient can experience neurological problems up until the day that missing bone is replaced. In a rat model, we believe that placing our new flexible material during the first surgery that can later turn into bone will still allow the brain to swell initially, while avoiding the second surgery and the neurological problems.

PI_NAMEs: ANDREWS, BRIAN T;DETAMORE, MICHAEL S. (contact);NUDO, RANDOLPH J.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3D Print;Acceleration;Address;animal model selection;Animals;Anti-Inflammatory Agents;Anxiety;Area;base;Behavior;Behavioral;Biocompatible Materials;biomaterial development;Biomedical Engineering;bioprinting;bone;Bone Matrix;Bone Regeneration;bone repair;Brain;Brain Edema;Brain Injuries;Calvaria;Caring;Cartilage;Cause of Death;Cephalic;Cessation of life;Clinic;Clinical Trials;Closed head injuries;Cognitive;Complication;Control Groups;craniofacial bone;cranium;cranium plastic repair;crosslink;Crosslinker;Custom;Data;Defect;demineralization;design;disability;Drug Delivery Systems;Edema;Emergency department visit;Encephalitis;Evaluation;experience;fascinate;Female;flexibility;Formulation;Goals;Headache;healing;Histology;Hospitalization;Hyaluronic Acid;Hydrogels;Implant;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Industry;innovation;interest;Intracranial Pressure;Left;Letters;Life;local drug delivery;Magnetic Resonance Imaging;male;Medical;Mental Depression;Modeling;Modernization;Motor;motor deficit;multidisciplinary;Mus;Musculoskeletal;Neurologic;Neurologic Deficit;neurological recovery;neurosurgery;Neurosurgical Procedures;nonhuman primate;novel;Operative Surgical Procedures;Organ;Osteoblasts;osteogenic;particle;particle exposure;Paste substance;Patients;Pharmaceutical Preparations;Pliability;preservation;Procedures;Process;Property;Rattus;Recovery;Regenerative Medicine;Resolution;Rheology;Scalp structure;Solid;Speed;standard of care;Stroke;Surgeon;Survivors;Swelling;Symptoms;synergism;TBI Patients;TBI treatment;Tendon structure;Testing;Thinness;Time;Tissues;tool;translational impact;Traumatic Brain Injury;Ultraviolet Rays;United States;virtual

PROJECT_TITLE: Single stage surgical intervention for treatment of severe traumatic brain injury

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: EUGENE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed work will contribute to our knowledge about the neural, cognitive, and computational mechanisms involved in human action control. This research will help determine which specific mechanisms are impacted in motor disorders and help identify new targets for therapy. Isolating specific mechanisms will improve our ability to treat and potentially cure disorders such as Parkinson’s disease, dystonia, and stroke.

PI_NAMEs: GREENHOUSE, IAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Agonist;Anatomy;Animals;Behavior Control;Behavioral;behavioral impairment;Brain;Butyric Acids;Chemicals;Clinical Research;Cognitive;cognitive process;Data;Dimensions;Disease;Dystonia;Electromyography;Etiology;Evoked Potentials;Exhibits;experimental study;Future;gamma-Aminobutyric Acid;Ganglia;goal oriented behavior;Goals;Grain;Human;Impairment;improved;Individual;Individual Differences;Influentials;innovation;Knowledge;Laboratories;Link;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Modeling;Motor;Motor Cortex;motor disorder;motor symptom;Muscle;neural;neurochemistry;Neurocognitive;Neurons;Neurotransmitters;new therapeutic target;Noise;noninvasive brain stimulation;novel;novel marker;operation;Output;Parkinson Disease;Pathway interactions;Pattern;Physiological;Population;Preparation;Property;Publishing;recruit;Research;response;Rest;Role;sensory cortex;sensory system;Shapes;Signal Transduction;Stroke;Symptoms;System;Task Performances;Techniques;Testing;Therapeutic Intervention;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Computational roles of inhibition in human action control

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PI: Kurshan, Peri T. Project Narrative  Mutations in synaptic cell-adhesion molecules such as neurexins are highly associated with neurodevelopmental and neuropsychiatric disorders and often lead to defects in synapse formation, although the molecular mechanisms by which this occurs are still largely unknown. In this proposal, we seek to understand the cell-intrinsic mechanisms by which presynaptic cell-adhesion molecules including neurexin are localized to synapses and contribute to their maturation. As a result, this research will have the potential to reveal novel therapeutic approaches to target diseases associated with defects in this critical class of synaptic proteins.

PI_NAMEs: KURSHAN, PERI T (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Actins;Address;Affect;Alleles;autism spectrum disorder;Axon;Binding;Biological;Biological Models;Biology;Brain;Caenorhabditis elegans;Cell Adhesion;Cell Adhesion Molecules;Cells;Cues;Cytoskeleton;Data;Defect;Dependence;Development;Disease;Disparate;extracellular;Functional disorder;Genetic;genetic approach;Goals;Growth Cones;imaging approach;In Vitro;in vivo;information processing;innovation;Integral Membrane Protein;Intellectual functioning disability;Kidney;Kinesin;Knowledge;Mammals;Mediating;Modeling;Molecular;Molecular Motors;Motor;mutant;Mutation;Nematoda;nephrin;Nervous System;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;neuropsychiatric disorder;new therapeutic target;novel therapeutic intervention;Optics;Phase;Physical condensation;podocyte;polymerization;Polymers;Positioning Attribute;preservation;presynaptic;Process;programs;Protein Biosynthesis;Protein Isoforms;protein transport;Proteins;Publishing;Recording of previous events;recruit;Research;Role;scaffold;Scaffolding Protein;Schizophrenia;Signal Transduction;Site;Stereotyping;Synapses;Synaptic Cleft;synaptic function;synaptogenesis;System;Testing;Therapeutic Intervention;trafficking;Translations;Vesicle

PROJECT_TITLE: Cell-intrinsic mechanisms of presynaptic assembly

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Untreated peripheral nerve damage results in a tangled mass of disorganized nerve fibers and blocks functional recovery following nerve injury. While significant advances in understanding the molecular mechanisms governing the repair process have been made in recent years, the clinical results of peripheral nerve repair remain disappointing. This proposal seeks to improve nerve repair by mimicking endogenous cues using topographical guidance and concentration gradients of ECM-peptides and growth factors.

PI_NAMEs: BECKER, MATTHEW L (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acceleration;Axon;axon regeneration;Binding;Biocompatible Materials;biodegradable polymer;cell motility;cell type;Cells;Clinic;Clinical;Cues;Data;Defect;Diameter;Elements;experience;extracellular;Extracellular Matrix;fabrication;Fiber;Goals;Growth;Growth Factor;healing;improved;improved outcome;In Vitro;in vivo;Infiltration;Injury;injury and repair;innovation;Integrin Binding;interest;Knowledge;Laboratories;Laminin;Limb structure;long term recovery;Macrophage;migration;Modeling;Molecular;Molecular Analysis;Motivation;motor function recovery;nanofiber;Nanofiber Scaffold;nanopolymer;Natural regeneration;Nerve Block;Nerve Fibers;nerve injury;Nerve Regeneration;nerve repair;Neurites;Neurofibrillary Tangles;Neurons;novel;Operative Surgical Procedures;Outcome;Pathway Analysis;Pathway interactions;Peptide Fragments;Peptides;peptidomimetics;peripheral nerve damage;Peripheral nerve injury;peripheral nerve regeneration;peripheral nerve repair;Peripheral Nerves;Play;Process;Protein Fragment;Proteins;Rattus;reconstruction;Recovery;Recovery of Function;recruit;regenerative;Regenerative capacity;repaired;Reporting;Research;response;Role;Schwann Cells;sciatic nerve;Sensory;Site;Speed;Touch sensation;Transforming Growth Factor beta;Translation Process;Translations;Trauma;tyrosyl-isoleucyl-glycyl-seryl-arginine;United States;Work

PROJECT_TITLE: Synergistic Enhancement of Peripheral Nerve Defect Repair using Peptide Functionalized Aligned Nanofiber Conduits

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The precise establishment of neuronal connectivity during development is critical for normal nervous system function. This proposal examines the molecular mechanisms underlying local protein synthesis to determine how it regulates the formation of neuronal connectivity. These studies will provide a greater understanding about the complex nature of brain development in health and disease.

PI_NAMEs: WELSHHANS, KRISTY  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Acute;Adhesions;Axon;axon growth;axon guidance;beta Actin;Binding;Biological Assay;Brain;Complex;Coupled;Cues;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Filopodia;Growth;Growth Cones;Health;Integrins;Knowledge;Laminin;Link;Location;Mediating;Messenger RNA;Methods;Microfilaments;Microtubules;Molecular;Motility;Movement;mRNA Translation;Mus;Nature;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;neurodevelopment;Neurons;neurotransmission;novel;Positioning Attribute;Process;Protein Biosynthesis;Protein Isoforms;Proteins;Regulation;Reporter;Research;response;RiboTag;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;Structure;Synapses;synaptogenesis;Testing;Total Internal Reflection Fluorescent;trafficking;Translating;translating ribosome affinity purification and RNA-sequencing;Translational Regulation;Translations

PROJECT_TITLE: Regulating axon guidance through local translation at adhesions

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Aberrant behaviors of neural stem and progenitor cells (NSPC) during brain development can lead to cortical malformations, such as microcephaly and macrocephaly, as well as various neurodevelopmental disorders. Knowledge about precise control of NSPC behaviors is essential to dissecting the underlying pathogenic mechanisms. Our proposed studies will provide novel insights to how a selective RNA decay mechanism can influence NSPC behaviors and to the etiology of microcephaly.

PI_NAMEs: ZHENG, SIKA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Affect;Behavior;Biochemical;Biology;Brain;cell behavior;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell determination;Cell Lineage;cell type;Cells;Characteristics;Collaborations;Computational Biology;conditional knockout;Cortical Malformation;Data;daughter cell;Defect;Development;developmental neurobiology;Ensure;Equilibrium;Etiology;Genes;Genetic;Genetic Transcription;In Vitro;in vivo;insight;Knock-out;Knockout Mice;Knowledge;Length;Link;Macrocephaly;Measures;Mediating;Messenger RNA;Methods;Microcephaly;Molecular;Mothers;mouse genetics;mRNA Decay;mRNA Stability;Mutation;Neocortex;nerve stem cell;nestin protein;neural;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;neuroregulation;Neurosciences;Nonsense Codon;Normal Cell;novel;Output;Pathogenicity;Pathway interactions;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;postmitotic;posttranscriptional;Process;progenitor;Proliferating;Radial;Recording of previous events;Regulation;Regulatory Pathway;Reporting;RNA;RNA chemical synthesis;RNA Decay;RNA Degradation;RNA Processing;Role;Shapes;spatiotemporal;stem;stem cell differentiation;stem cells;Testing;Time;tool;TP53 gene;Transcript;transcription factor;transcriptomics

PROJECT_TITLE: The Role of NMD in Cortical Neural Progenitor Cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Heart Disease;Lymphatic Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Understanding the regenerative response of the nervous system in models that naturally regenerate is integral to the development of potential therapies for traumatic brain injury and stroke. The proposed studies in the zebrafish seek to investigate the mechanisms through which meningeal lymphatics contribute to adult neurogenesis and regeneration of the nervous system by regulating the immune response and composition of cerebral spinal fluid. Through these studies we will gain novel insights into the mechanisms that underpin the relationship between the lymphatic system and promoting the regenerative response of the central nervous system.

PI_NAMEs: HARRISON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Acute;Address;Adult;adult neurogenesis;American;Animals;Behavior;Biology;Body System;Brain;brain dysfunction;Brain Injuries;Cardiac;cardiac regeneration;cell behavior;Cells;Central Nervous System;Cerebrospinal Fluid;chemokine;Child;Cicatrix;Clinical;Clinical Trials;Cognition;Collaborations;Comprehension;defined contribution;Development;disability;Fluid Balance;Genetic;Goals;healing;Health;Heart;Heart Injuries;Homeostasis;Human;Image;Imaging Techniques;Immune;Immune response;immunoregulation;Impairment;improved;improved outcome;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;insight;Investigation;Knowledge;Lead;Leucocytic infiltrate;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphocyte;Mammals;Mass Spectrum Analysis;Mediating;Meningeal lymphatic system;Modeling;Molecular;Motility;Natural regeneration;Nerve Regeneration;Nervous System;neurogenesis;neuron regeneration;Neurons;neurotropic;new technology;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Physical therapy;Play;Population;Positioning Attribute;prevent;programs;Publishing;regenerative;regenerative repair;Regenerative response;Rehabilitation therapy;repaired;Research;response;response to brain injury;response to injury;Role;Signal Pathway;Signal Transduction;Skin;Skin Tissue;Specific qualifier value;Speech;Stroke;Symptoms;System;Systems Development;TBI Patients;TBI treatment;Techniques;Testing;time use;Tissue Model;tissue regeneration;tissue repair;Tissues;tool;trafficking;transcriptomics;Transgenic Organisms;Traumatic Brain Injury;Traumatic injury;United States;Vascular Endothelial Growth Factor C;Vertebrates;Vision;Visualization;wasting;Work;young adult;Zebrafish;zebrafish development

PROJECT_TITLE: Lymphatic support of neurogenesis and regeneration


ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Synapses are the primary substrates driving information transfer throughout our nervous system. Defects in synaptic communication are associated with a vast number of neurological, neurodegenerative, and neuropsychiatric diseases including epilepsy, autism, schizophrenia, ALS, and Alzheimer’s Disease. While their importance is undeniable, the mechanisms that establish and modulate the diversity of synaptic strength remain enigmatic. This proposal seeks to reveal fundamental insights into what determines and adaptively modifies the diversity of presynaptic function at glutamatergic synapses in development and plasticity. Ultimately, this knowledge is necessary to understand the etiology of neural diseases resulting from synaptic dysfunction and develop effective therapeutic strategies.

PI_NAMEs: DICKMAN, DION KAI (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;autism spectrum disorder;Automobile Driving;Biological Models;botulinum toxin type C;Botulinum Toxins;Calcium;Calibration;Chemosensitization;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Coupling;Data;Defect;Development;Disease;Drosophila genus;Electrophysiology (science);Epilepsy;Etiology;experience;experimental study;Failure;fly;Functional disorder;Genes;Genetic;Glutamates;Goals;Health;Heterogeneity;Homologous Gene;imaging approach;Individual;innovation;insight;Knowledge;Mammals;Mental disorders;Microscopy;Modeling;Molecular;Molecular Machines;Motor;Motor Neurons;Muscle;Muscle Contraction;Mutagenesis;nanoscale;Nanostructures;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuromuscular Junction;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neurotransmission;neurotransmitter release;Orthologous Gene;Phase;Positioning Attribute;postsynaptic;presynaptic;prevent;Process;Property;Protein Isoforms;ratiometric;Reagent;Reporter;RNA Splicing;Role;scaffold;Schizophrenia;Site;Structure;superresolution imaging;Synapses;synaptic function;Synaptic plasticity;System;therapeutically effective;Toxic effect;transmission process;ultra high resolution;Vesicle

PROJECT_TITLE: Generating functional diversity from molecular homogeneity at glutamatergic synapses

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HERSHEY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE JC polyomavirus (JCPyV), a prevalent human-only pathogen, causes life-threatening brain diseases in immunologically compromised individuals. The list of immunotherapeutic and chemotherapeutic agents linked to JCPyV CNS diseases is rapidly expanding; no anti-JCPyV agents are available. Using a mouse virus in the same family as JCPyV, we developed a tractable animal model to explore early stages in the pathogenesis of polyomavirus brain infections that precede development of irreversible lesions.

PI_NAMEs: LUKACHER, ARON ELIOT (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Animal Model;Autoimmune;Biological Products;Brain;Brain Diseases;brain parenchyma;Capsid Proteins;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Central Nervous System Diseases;Central Nervous System Infections;Cerebrum;chemotherapeutic agent;chronic infection;Complication;Cryoelectron Microscopy;Custom;Demyelinations;Development;Disease;drug withdrawal;Ependyma;Epitopes;Event;Family;Foundations;Hematologic Neoplasms;Heterogeneity;Human;human pathogen;image reconstruction;Immune;immune modulating agents;Immunity;Immunologics;Immunotherapeutic agent;in vivo;in vivo evaluation;Incidence;Individual;Infection;Inflammatory;interleukin-21;Invaded;JC Virus;Lesion;Life;Link;Maintenance;Maps;Memory;Modeling;mortality;mouse polyomavirus;multiple sclerosis patient;Mus;Mutation;natalizumab;Natural Immunity;neuropathology;neutralizing antibody;next generation sequencing;pathogen;Pathogenesis;Patients;Polyomavirus;preservation;Progressive Multifocal Leukoencephalopathy;Reaction;Relapse;Resolution;Staging;STAT1 gene;T cell response;T-Lymphocyte;Therapeutic;Three-Dimensional Imaging;tissue culture;Tropism;Tysabri;Variant;Ventricular;Virus;Visualization

PROJECT_TITLE: Deciphering Early Stages of Polyomavirus CNS Pathogenesis and Immunity


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative – Overall Acute intoxication with organophosphate (OP) pesticides or nerve agents can trigger seizures that rapidly progress to life-threatening status epilepticus, and survivors often experience significant long-term morbidity, including progressive brain injury, spontaneous recurrent seizures, and cognitive impairment. Current medical countermeasures for acute OP intoxication can prevent death, but are unable to fully protect against the long- term adverse neurological consequences unless administered within minutes of exposure, which is an unlikely scenario in the event of accidental, suicidal or terrorist-related exposures. The UC Davis CounterACT Center of Excellence seeks to identify and develop novel disease-modifying therapeutic strategies that can be administered in hours to months after exposure to delay the onset and/or reduce the severity of chronic neurotoxic effects.

PI_NAMEs: BROOKS-KAYAL, AMY R.;LEIN, PAMELA J (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acute;Address;Adult;Analytical Chemistry;Area;Atropine;Automobile Driving;Behavioral;Benzodiazepines;Biological Markers;biomarker identification;blood-brain barrier function;Brain;Brain Injuries;Calpain;candidate identification;Cessation of life;cholinergic;Cholinesterase Inhibitors;Chronic;Clinical;combinatorial;Data;Data Analyses;Deep Brain Stimulation;Detection;Development;Disease;education research;Electrophysiology (science);Epilepsy;Epoxide hydrolase;equity, diversity, and inclusion;Event;experience;Experimental Designs;Exposure to;FDA approved;Female;forging;Formulation;Goals;Hour;Human;Image;Impaired cognition;Impairment;improved;in vivo;indexing;Individual;Industrial Accidents;Inflammation;innovation;Intellectual Property;Interleukin-1 beta;Intervention;Intoxication;Ion Channel;Isoflurophate;Learning;Life;Link;male;mass casualty;medical countermeasure;meetings;Memory;Mentors;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;nerve agent;Nerve Degeneration;Nervous System Physiology;neuroimaging;neuroinflammation;Neurologic;Neurologic Effect;Neurological outcome;neuronal excitability;neuropathology;neurotoxic;neurotoxicity;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organophosphates;Outcome;Oximes;Pathogenesis;Pathogenicity;Pathway interactions;Pesticides;Pharmaceutical Chemistry;pharmacologic;Phase;Pilot Projects;Plasminogen Activator Inhibitor 1;pre-clinical;Pre-Clinical Model;preclinical study;predictive marker;prevent;programs;Rattus;recruit;Recurrence;Research;Research Personnel;Research Project Grants;response;Risk;Rodent;Science;Scientist;Seizures;Severities;Signal Transduction;small molecule inhibitor;Soman;standard of care;statistics;Status Epilepticus;suicidal;Survivors;Testing;Therapeutic;therapeutic candidate;Toxic effect;Training;Translating;United States National Institutes of Health

PROJECT_TITLE: UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(50)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2024 Alcohol and the Nervous System Gordon Research Conference and the associated Gordon Research Seminar will provide a unique forum that brings together a diverse range of young and established alcohol researchers to discuss groundbreaking advances in alcohol neuroscience research. The innovative GRC format will promote discussions and focus on building bridges in neuroscience research between preclinical and clinical researchers, and foster a community of the next generation of alcohol researchers. The goal of this conference is to stimulate cutting edge research in the field and contribute to the advancement of alcohol research across multiple domains.

PI_NAMEs: BESHEER, JOYCE  (contact);SINHA, RAJITA

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Area;Automobile Driving;Brain;career;career development;Clinical;Collaborations;Communities;COVID-19;Development;Ensure;Environment;Fees;Fostering;Functional disorder;Future;Goals;graduate student;Growth;Individual;innovation;Knowledge;meetings;Mission;National Institute on Alcohol Abuse and Alcoholism;Nervous System;Neurosciences;Neurosciences Research;next generation;Participant;Postdoctoral Fellow;posters;pre-clinical;Request for Applications;Research;research and development;Research Personnel;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Shapes;Structure;student participation;success;symposium;Techniques;Texas;Time;Training;Translational Research;translational scientist;Travel;unpublished works

PROJECT_TITLE: 2024 Alcohol and the Nervous System Gordon Research Conference and Gordon Research Seminar


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The global objective of this proposal is to investigate the tissue-specific causative role of aberrant mitochondrial Ca2+ uptake in skeletal muscle and motor neuron in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. Specifically, we will determine the impact of aberrant mitochondrial Ca2+ uptake in skeletal muscle and/or motor neuron on the survival, motor neuron loss, exercise performance, muscle force generation, neuromuscular junction structure/function, and intracellular Ca2+ release properties and mitochondrial function in skeletal muscle fibers, at different stage of disease progression in two established mouse models of ALS. Results from this project will provide pre-clinical evidence needed to determine whether excessive mitochondrial Ca2+ uptake in skeletal muscle and motor neuron is a viable therapeutic target for ALS treatment.

PI_NAMEs: WEI-LAPIERRE, LAN  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adult;Alleles;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animals;Attenuated;attenuation;Axon;axonopathy;behavioral study;Bioenergetics;Brain;Buffers;C9ORF72;Cell Death;Cell Membrane Permeability;Cuprozinc Superoxide Dismutase;Defect;Degenerative Disorder;Disease;Disease Progression;Dissection;Distal;DNA-Binding Proteins;Dominant-Negative Mutation;effective therapy;Electron Microscopy;Event;Exercise;extend lifespan;extensor digitorum;Generations;Genes;Genetic;Genetic Models;Homeostasis;Immunohistochemistry;improved;In Situ;in vivo;Measurement;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Motor;Motor Neurons;mouse model;Mus;Muscle;Muscle Contraction;Muscle denervation procedure;Muscle Fibers;Muscle function;muscular structure;Mutation;Neurodegenerative Disorders;Neuromuscular Junction;neuron loss;neuronal survival;new therapeutic target;Onset of illness;Outcome;Paralysed;Pathogenesis;Pathologic;Pathology;Patients;Performance;Phenotype;postsynaptic;pre-clinical;preservation;presynaptic;prevent;Property;Reporting;Research;Respiratory Chain;Respiratory Failure;Role;Signal Transduction;Skeletal Muscle;Soleus Muscle;Spinal Cord;Structure;Symptoms;System;Testing;Therapeutic Effect;therapeutic target;Tissues;Transgenic Mice;Treatment Efficacy;uptake;Western Blotting

PROJECT_TITLE: Using mitochondrial Ca2+ uptake as a therapeutic target for ALS

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This application focuses on using genetically engineered mice and patient derived xenograft models of neurofibromatosis type 1 to characterize the role of the TAM family receptors in the initiation and progression of plexiform neurofibroma to malignant peripheral nerve sheath tumor. These studies will also test AXL inhibitory agents and other key small molecules in peripheral nerve sheath tumor growth and progression.

PI_NAMEs: CLAPP, DAVID W (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;analog;angiogenesis;Antitumor Response;Benign;Binding;Biological Markers;cancer predisposition;cancer stem cell;CDK4 gene;Cells;Cessation of life;Child;Clinic;Clinical;Clinical Data;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Complex;Development;effective therapy;efficacy evaluation;Family;FDA approved;Genetically Engineered Mouse;genome analysis;Genomics;Germ-Line Mutation;Growth;Human;Human Genetics;human subject;Immune;Immunologics;Immunotherapeutic agent;implantation;Individual;inhibitor;insight;Laboratories;Lesion;Link;LoxP-flanked allele;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;man;Measures;MEK inhibition;MEKs;MERTK gene;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Neural Crest;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;new therapeutic target;NF1 gene;non-invasive monitor;Non-Malignant;novel;novel therapeutic intervention;Orphan;Orphan Drugs;overexpression;Participant;patient derived xenograft model;Patients;Peripheral Nerve Sheath Neoplasm;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacokinetics and pharmacodynamics;pharmacologic;Phase II Clinical Trials;phase II trial;Phenotype;Phosphotransferases;Plasma;Plexiform Neurofibroma;pre-clinical;premalignant;premature;prevent;Probability;Prognostic Marker;prognostic value;Proteins;receptor;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;Receptor Signaling;response;Role;Sarcoma;Series;Serine;small molecule;small molecule inhibitor;stem cells;Syndrome;synergism;targeted treatment;Testing;Toxic effect;treatment response;tumor;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor Suppressor Genes;tumorigenic;Tyrosine Kinase Inhibitor;Tyrosine Kinase Receptor Inhibition;Work;Xenograft Model

PROJECT_TITLE: TAM receptor inhibition in NF1-associated peripheral nerve sheath tumors

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The cerebellum is a structure that is critical for control of movements. However, activities of cerebellar neurons are often difficult to interpret in terms of behavior. Here, we propose new algorithms and experimental procedures that will significantly improve the ability to tackle the question of neural population coding in the cerebellum, ultimately producing a better understanding of how the cerebellum learns to precisely control movements.

PI_NAMEs: SHADMEHR, REZA  (contact)

PROJECT_TITLE: Control of movements by the cerebellum

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Neurodevelopmental disorders are common in the population, representing a significant burden in all aspects of life and society. Studies aimed at identifying underlying genetic causes and mechanisms of these disorders will lead to a better understanding of the underlying biological mechanisms and, in turn, facilitate development of improved diagnostic methods and potential treatments.

PI_NAMEs: DENNIS, MEGAN Y (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;Address;autism spectrum disorder;autistic children;Biological;Biological Assay;Brain;Candidate Disease Gene;Categories;causal variant;Cell Cycle;Cell Proliferation;cell type;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;comorbidity;Confocal Microscopy;cost;Coupled;Data;de novo mutation;Defect;Development;Developmental Gene;Diagnostic;Diagnostic Procedure;Disease;Drops;Early Intervention;Early treatment;Embryo;Etiology;Exhibits;experimental study;Fetal Development;Fishes;Future;gene function;Gene Mutation;gene-editing approach;Genes;Genetic;Genetic Markers;Genetic Risk;genetic variant;genome editing;genome sequencing;Genomic approach;Goals;Growth;Heterozygote;Human;Image;improved;in vivo;Individual;individuals with autism spectrum disorder;knock-down;Knock-out;Language;Larva;Lead;Life;loss of function;Loss of Heterozygosity;Macrocephaly;Measures;Megalencephaly;Methods;Microinjections;Missense Mutation;Modeling;Molecular;Mus;mutant;Mutation;neural;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurons;novel;Organoids;Orthologous Gene;Pathogenicity;Patients;Phenotype;Population;proband;Prognosis;PTEN gene;Publishing;rapid test;Recurrence;Reporting;Reproduction;Research;single-cell RNA sequencing;small molecule;Societies;transcriptome sequencing;Validation;Variant;variant of unknown significance;Work;Zebrafish

PROJECT_TITLE: Parallel assessment of neurodevelopment genes implicated in autism using zebrafish

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: TUCSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  The manner in which the brain responds to cumulative traumatic brain injuries (TBIs) and leads to neurological dysfunction is unknown. Our approach permits inter-injury in vivo microscopy to observe injury- induced change in blood flow and blood-brain barrier permeability, while recording post-traumatic sleep, as predictors of subacute neurological function. New insights to cumulative pathophysiology after TBI can inform clinical management and studies to reduce damage and accelerate recovery.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Affective;Anesthesia procedures;Anxiety;Automobile Driving;Behavior;Behavioral;Biomechanics;Blood flow;blood-brain barrier disruption;blood-brain barrier permeabilization;Blurred vision;Brain;Brain Concussion;care costs;Cephalic;Cerebrovascular Circulation;Chronic;Clinical;Clinical Management;Clinical Research;Closed head injuries;Cognitive;Data;Dextrans;Diagnosis;Disinhibition;Dizziness;Drops;Drowsiness;Emotional;executive function;Experimental Designs;Extravasation;Female;fluorescein isothiocyanate dextran;Fluorescence;fluorescence microscope;Functional disorder;Future;Head;head impact;Headache;healing;Health Care Costs;Helmet;Hyperalgesia;Image;imaging modality;Immune;Impairment;in vivo;in vivo imaging;Individual;Injury;insight;Intensive Care;Intervention;intraperitoneal;Investigation;Learning;Location;male;Measures;Mechanics;Memory;Mental Depression;Microscope;Microscopy;mild traumatic brain injury;miniaturize;Modeling;Molecular Weight;Monitor;multimodality;Mus;Nervous System Physiology;neural;neurobehavior;neurobehavioral;neurochemistry;Neurologic;Neurologic Dysfunctions;Neurological outcome;neurophysiology;novel;Outcome;Pain;Pathology;Patients;Performance;Permeability;Persons;Phenotype;Physiological;Physiology;Polysomnography;Post-Concussion Syndrome;pre-clinical;pressure;Procedures;Prognosis;prospective;Quality of life;Recovery;Reporting;response;restraint;Risk;Risk Assessment;Rodent;Rotation;sensor;Sensory;Severities;Sleep;Sleep Disorders;Sleeplessness;societal costs;somatosensory;spatial memory;Speed;Symptoms;Techniques;Technology;Testing;Therapeutic Intervention;Time;timeline;Tracer;Traumatic Brain Injury;United States;Vasodilation;Visualization;Weight;Width

PROJECT_TITLE: Miniscope in vivo imaging of cumulative traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The BRAIN initiative has enabled the development of approaches for modulating specific microcircuits through genetically targeting discrete types of neurons; however, their application to disease models is lagging. In this collaboration between Huntington’s disease (HD) researchers and BRAIN tool developers we will utilize novel interventional tools for changing neural circuit dynamics at the early, pre-symptomatic stage for preventing or delaying and mitigating the behavioral deficits in a transgenic mouse model of HD. Our project will drive translational progress toward potential novel therapeutic purposes for HD as well as other neurodegenerative diseases that show circuit imbalances, while at the same time addressing basic questions of neural circuit function underlying behavior relevant to both NINDS and NIMH.

PI_NAMEs: HOCHGESCHWENDER, UTE H (contact);ROSSIGNOL, JULIEN

PROJECT_TERMS: Address;Adenine;Affect;Behavior;Behavioral;Behavioral Research;Brain;Brain Diseases;BRAIN initiative;Cell Survival;Cellular Morphology;Chimeric Proteins;Cognition;Cognitive deficits;Collaborations;Communication;Compensation;Complex;Corpus striatum structure;Cytosine;Development;Disease;disease model;Disease Progression;DNA Sequence Alteration;Early Intervention;efficacious treatment;Electrophysiology (science);Event;Excitatory Synapse;Exons;Genes;Genetic;Goals;Guanine;hippocampal pyramidal neuron;Human;Huntington Disease;Huntington gene;Hyperactivity;Interneurons;Intervention;Ion Channel;Light;light emission;Link;Luciferases;luciferin;Mental Health;mouse model;Movement;Mus;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Neocortex;neural;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;neuropathology;novel;novel therapeutics;Opsin;optogenetics;Output;Parvalbumins;Pathogenesis;Pathologic;Patients;Peripheral;Persons;Phase;Physiological;Population;postsynaptic;postsynaptic neurons;preservation;presynaptic;prevent;Process;Regulation;Research;Research Personnel;sensor;Symptoms;Synapses;Synaptic Transmission;Target Populations;Testing;Therapeutic;Time;tool;tool development;Transgenes;Transgenic Mice;translational progress;Triplet Multiple Birth

PROJECT_TITLE: Targeted Circuit Manipulation for Ameliorating Huntington's Disease Pathogenesis


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Alzheimer’s Disease (AD) is one of the most prevalent and devastating neurodegenerative diseases in the modern era, impacting millions of people worldwide and with incidence projected to triple as the population continues to age. Underlying the many processes that may contribute to Alzheimer’s are two potential factors: dysfunctional cerebral blood flow and inflammation. The goal of this study is the preclinical assessment of our novel small molecule inhibitors of NADPH Oxidase 2, an oxidant generating protein known to be involved in both processes, as a potential therapeutic option in AD mouse models.

PI_NAMEs: PAGANO, PATRICK J (contact);VAZQUEZ, ALBERTO L

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;abeta deposition;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Amyloid beta-Protein;APP-PS1;Autopsy;Biochemical;Biological Availability;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;brain tissue;Cells;Cephalic;cerebrovascular amyloid;Cerebrovascular Circulation;Cerebrovascular Disorders;Cognitive deficits;Complex;cost;cytokine;Dementia;Deposition;Development;Disease;Disease Management;Disease Progression;Enzyme-Linked Immunosorbent Assay;extracellular;Foundations;Fractionation;frontal lobe;Functional disorder;Future;glial activation;Gliosis;Glucose;Goals;Health Expenditures;Hippocampus;Homeostasis;Human;hyperphosphorylated tau;Impaired cognition;improved;in vivo Model;Incidence;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;Interleukin-1 beta;Interleukin-6;Laboratories;Laser-Doppler Flowmetry;Leukocytes;life span;Ligation;Link;Macrophage;Mass Spectrum Analysis;Measures;Mediating;Medical;Microglia;Modernization;Molecular;Morphology;mouse model;Mus;NADPH Oxidase;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;Neuronal Dysfunction;Neurons;neutrophil;novel;Oral;overexpression;Oxidants;Oxygen;Parkinson Disease;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Play;Population;pre-clinical assessment;Process;Production;Proteins;Reactive Oxygen Species;Regulation;Role;Senile Plaques;Signal Transduction;small molecule;small molecule inhibitor;Solid;stem;Synapses;tau aggregation;tau Proteins;Testing;Therapeutic;Time;Tissues;TNF gene;two photon microscopy;Vascular Smooth Muscle;Work

PROJECT_TITLE: NOX2 Small Molecule Inhibitors as a Therapeutic Strategy in the Treatment of Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-E (90)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Successful control of chronic viruses, such as HIV and HCV, greatly depends on vigorous and well-coordinated CD4+ and CD8+ T cell responses. This study aims to identify cellular and molecular mechanisms, as well as rational designs of therapeutics, that favor the formation and function of effector CD8+ T cells and overcome T cell exhaustion to treat chronic infection and cancer.

PI_NAMEs: CUI, WEIGUO  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Affect;Agonist;Antigens;Automobile Driving;Avidity;Back;Biological;CD4 Positive T Lymphocytes;CD40 Antigens;CD8-Positive T-Lymphocytes;CD80 gene;Cell Differentiation process;Cell Physiology;Cells;Cellular Structures;Chronic;chronic infection;Chronic Phase;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;computerized tools;CRISPR screen;Cross Presentation;cytokine;Data;Dendritic Cells;Effector Cell;effector T cell;exhaust;exhaustion;experimental study;Genes;Genetic;Genetic Models;Genetic Transcription;HIV/HCV;improved;Individual;Infection;insight;interleukin-21;Knowledge;Licensing;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Modeling;Molecular;novel;pathogen;PD-1 blockade;Persons;Phenotype;Population;Process;progenitor;programmed cell death protein 1;Publishing;rational design;receptor;Research;Research Personnel;Role;Signal Transduction;single-cell RNA sequencing;Solid;stem;stem cells;Structure;T cell differentiation;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;TNFRSF5 gene;transcriptomics;Validation;Viral;Virus;Virus Diseases;XCR1 gene

PROJECT_TITLE: TCR signaling strength regulated T cell differentiation during chronic viral infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Asthma;Genetics;Lung;Neurosciences

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Project Narrative This proposal aims to investigate immunoglobulin E overproduction by the sensitization and reflex augmentation of sensory neurons and efferent autonomic nervous system activation. The proposed research is relevant to public health because a better understanding of the complete neuro-immune landscape and its dysregulation with fungal asthma will increase understanding of fundamental mechanisms involved in allergic/asthmatic pathology, of which immunoglobulin E is at its core. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: JENDZJOWSKY, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Ablation;adaptive immunity;Affect;Afferent Neurons;Affinity;Allergens;Allergic;Allergic inflammation;Alternaria;Antigen Receptors;Antigens;Asthma;asthmatic;autonomic nerve;Autonomic nervous system;B-Cell Antigen Receptor;B-Lymphocytes;Basophils;Benign;Binding;Biological;Biological Assay;Biology;Bone Marrow;Brain region;Brain Stem;Calcium;Cell Lineage;Cell Separation;cell type;Cells;Complex;Cytokine Signaling;Data;Development;disability;Drug Targeting;Efferent Neurons;Electrophysiology (science);experimental study;Extrinsic asthma;Flow Cytometry;Future;Generations;Genes;Genetic;Health;Hematopoiesis;Human;Hypersensitivity;IgE;Image;Imaging Techniques;Immune;Immunity;immunogenic;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunoglobulins;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Investigation;knock-down;Knowledge;Learning;Lung;Lymphocyte;Lymphoid;Lymphopoiesis;mast cell;Mediating;Mission;Molecular;mouse model;Mus;Nerve;Nervous System;neural;neural circuit;neural stimulation;Neuroimmune;neuronal circuitry;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;novel therapeutics;pathogen;Pathology;Pathway interactions;Phenotype;Population;Production;Proliferating;Public Health;Receptor Gene;Receptor Signaling;Reflex action;Regulation;Reporting;Research;response;Role;secondary lymphoid organ;Sensory;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specificity;Structure of germinal center of lymph node;Symptoms;System;Technology;Testing;Time;Tissues;tool;Tracer;TRP channel;United States National Institutes of Health;Up-Regulation;Venoms;Work

PROJECT_TITLE: Asthmatic inflammation requires neuronal upregulation of B-cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(57)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Antibiotic-resistant bacteria are a major public health concern. These bacteria cause infections that are often difficult to treat and lead to serious infections. Carbapenem-resistant Enterobacteriaceae (CRE) is a severe type of antibiotic-resistant bacteria because it is resistant to almost all antibiotics and can be very deadly. It is very important to identify which patients are at risk for CRE and to identify the best treatment for CRE. We propose to develop and test a tool that predicts whether a person carries CRE, and to identify the best treatment options for CRE infections. We will use large databases to find patients at risk for CRE and patient who have CRE infections. We will use computer programming and biostatistics to identify which patients are at risk and which treatments work best. At the end of the proposed work, we will have identified new avenues to prevent person-to-person transmission of CRE and improve therapy of CRE infections.

PI_NAMEs: CHOU, ANDREW  (contact)

PROJECT_TERMS: acute care;Adverse event;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotic-resistant organism;Antibiotics;Antimicrobial Resistance;Area;Awareness;Bacteria;Bacterial Antibiotic Resistance;Big Data;Big Data Methods;Bioinformatics;Biometry;Board Certification;carbapenem resistance;carbapenem-resistant Enterobacteriaceae;carbapenemase;Carbapenems;career;Categories;Ceftazidime;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinical risk;Clinical Trials;Clostridium difficile;college;combat;Combined Antibiotics;Combined Modality Therapy;Communicable Diseases;comorbidity;Complex;computer program;Dangerousness;Data;Data Science;Databases;Dedications;design;Disease Outbreaks;Doctor of Philosophy;Educational Status;Effectiveness;Enterobacter cloacae;Enterobacteriaceae Infections;Environment;evidence base;Exclusion;experience;Faculty;Formularies;Fostering;Future;Gram-Negative Bacteria;Guidelines;Health;Health Care Costs;Health care facility;high risk;Hospitalization;Hospitals;improved;Individual;Infection;Infection prevention;innovation;Institution;Intervention;Junior Physician;K-Series Research Career Programs;Klebsiella pneumoniae;Knowledge;Lead;Master of Science;Mathematics;Measures;Medical center;Medicine;Mentors;Meropenem;microbial genomics;Microbiology;mid-career faculty;military veteran;Modeling;Morbidity - disease rate;mortality;multi-drug resistant pathogen;nephrotoxicity;novel;Oncology;ototoxicity;Outcome;Patients;Performance;Persons;Physicians;Pilot Projects;Population;post-doctoral training;predictive tools;Prevalence;prevent;Prevention;Prevention program;Productivity;prospective;Public Health;Publications;Publishing;Recording of previous events;Regimen;Reporting;Research;Research Personnel;Research Priority;Resistance;resistant Klebsiella pneumoniae;Risk;Risk Factors;risk stratification;Safety;Scientist;screening;Sepsis;side effect;skills;Specialist;Statistical Models;statistics;success;surveillance strategy;Systems Biology;Techniques;Testing;tool;Training;transmission process;Treatment outcome;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Virulence Factors;virus related cancer;Work

PROJECT_TITLE: Using Big-Data to Identify & Prevent Transmission of Carbapenem-Resistant Enterobacteriaceae within VHA


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: PROJECT NARRATIVE (from parent R35) Innate immune systems provide critical defenses against microbial infections and are composed of both ancient and newly evolved proteins. To understand where our immune pathways came from and how they integrate new components, we study antibacterial responses in eukaryotes found across the Tree of Life. These diverse immune systems promise to yield new antimicrobials and to reveal how innate immune defenses can change over evolutionary time.

PI_NAMEs: LEVIN, TERA CATHERINE (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Amoeba genus;Animals;Anti-Bacterial Agents;Antibacterial Response;antimicrobial;Bacteria;Bacterial Infections;Biochemical;Cell model;Cells;Communicable Diseases;Dictyostelium;emerging pathogen;Environment;Eukaryota;Evolution;experimental study;flexibility;Genes;Genetic;Genomic approach;Haploidy;Immune;Immune system;Immunity;Infection;innate immune pathways;Innate Immune System;Life;microbial;Modernization;Molecular;Natural Immunity;novel;Organism;Parents;Pathway interactions;Phagocytes;Phylogenetic Analysis;Positioning Attribute;Proteins;Shapes;Signal Transduction;System;Time;tool;Trees

PROJECT_TITLE: TIR domains and the ancestry of innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because memory deficits occur in many psychiatric and neurological disorders and are common as a result of early life adversity. Identifying the neurophysiological mechanisms of memory retrieval in the developing brain will inform the design of effective interventions for alleviating memory impairment in children and thus have a positive impact on life-long wellbeing. Further, this project will pave the way to designing clinical tools to map memory in the developing brain that will influence diagnostic and therapeutic surgical approaches and ultimately improve quality of life in patients with drug- resistant focal epilepsy.

PI_NAMEs: OFEN, NOA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Adult;Age;age related;Behavior;Brain;Brain region;Child;Childhood;childhood epilepsy;Clinical;cognitive ability;Complex;Coupling;Cues;Data;Data Set;Databases;design;Development;Diagnostic;Drug resistance;early life adversity;effective intervention;Electroencephalography;Epilepsy;Evaluation;experience;Failure;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Goals;Human;Impairment;Implanted Electrodes;improved;Individual;Individual Differences;insight;Intractable Epilepsy;Link;Maps;Measures;medial temporal lobe;Mediating;Memory;Memory impairment;memory retrieval;Mental disorders;Methods;Michigan;Nervous System Disorder;neural;Neurologic;neurophysiology;Neuropsychology;novel;Operative Surgical Procedures;Partial Epilepsies;Participant;Patient Selection;Patients;Pediatric cohort;Pediatric Hospitals;pediatric patients;Performance;Personal Satisfaction;Phase;Prefrontal Cortex;Process;Productivity;programs;Property;Public Health;Quality of life;recruit;Research Personnel;Resolution;Retrieval;Sampling;spatiotemporal;Standardization;Techniques;Testing;Therapeutic;therapy design;tool;Visual;Visual Cortex

PROJECT_TITLE: Development of Memory Networks in Children


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE In this project supplement, a Colombian-American student centrally into our R01-funded project to study the key metabolic pathways directing hematopoietic stem cell (HSC) fate decisions. Mr. Carlos Hurtado Muñoz will be trained to perform all of the molecular, metabolomics and genetic assays and the data analyses in the Ito lab. Our goal is to provide the training experience that will build a skill set that Mr. Hurtado Muñoz will use a foundation for his career as an independent physician-scientist.

PI_NAMEs: ITO, KEISUKE  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acetyl Coenzyme A;Address;Affect;Age;American;aspirate;ATP Citrate (pro-S)-Lyase;Behavior;Bioinformatics;bioinformatics tool;Biological Assay;Biosensor;Bone Marrow;career;Cell division;Cells;Cellular Assay;Cholesterol;cholesterol biosynthesis;citrate carrier;Clinical;cofactor;cohort;Colombian;Communication;Consumption;Cues;Cytosol;Data;Data Analyses;Daughter;daughter cell;Dedications;Defect;design;Doctor of Philosophy;Environmental Risk Factor;Enzymes;Equilibrium;Ethics;Event;Exhibits;experience;fatty acid metabolism;fatty acid oxidation;fluorescence lifetime imaging;Fostering;Foundations;Funding;Future;Genes;Genetic;Glycolysis;Goals;Hematology;Hematopoietic;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Image;Impairment;improved;In Vitro;in vivo;Individual;insight;Institution;Leadership;lipid metabolism;Maintenance;member;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Methods;Mitochondria;Mitochondrial Inheritance;mitochondrial metabolism;Mitosis;Molecular;Monitor;Mothers;mouse model;Mus;NADH;NADP;Natural graphite;Optics;Outcome;Oxidases;oxidation;parent project;Pathway interactions;pharmacologic;Physicians;Play;Population;Principal Investigator;Process;Production;programs;Publications;Reaction;reconstitution;Research;Role;Scientist;segregation;self-renewal;Sister;skills;stem cell biology;stem cell division;stem cell function;stem cell homeostasis;Sterols;Structure;Students;Technical Expertise;Testing;Training;Translational Research;Transplantation;undergraduate student;United States;Work

PROJECT_TITLE: The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem Cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This proposal is clinically important by focusing on neurobiological mechanisms that underlie anxiety in the early stages of Alzheimer disease (AD). By examining the impact of AD on the neural circuitry of anxiety at multiple levels, this work will provide knowledge that could lead to novel therapies to treat anxiety in human AD patients. As anxiety has been associated with faster decline, such treatments may also have an impact to slow the progression of AD itself.

PI_NAMEs: MASURKAR, ARJUN VIJAY (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: 3xTg-AD mouse;adeno-associated viral vector;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer’s disease biomarker;Anti-Anxiety Agents;Anxiety;anxiety reduction;anxiety treatment;anxiety-like behavior;anxiety-related behavior;anxious behavior;Architecture;Behavior;Behavioral Assay;Benefits and Risks;Biological Markers;Calcium Signaling;cell type;Cerebrovascular Circulation;Clinical;cognitive performance;Data;Dependence;Disease;Disease Progression;Distress;Dorsal;Electrophysiology (science);executive function;experimental study;FOS gene;Functional disorder;Goals;Head;hippocampal pyramidal neuron;Hippocampus;Human;human data;Hyperactivity;Image;Immediate-Early Genes;Immunohistochemistry;Implant;improved;in vivo;Knowledge;Label;Link;Literature;Measures;Medial;Memory;microendoscope;Molecular;Motivation;mouse model;Mus;neural circuit;neurobiological mechanism;Neurons;neuropsychiatric symptom;novel therapeutics;Opsin;optogenetics;Outcome;patch clamp;Pathology;Patients;Perfusion;Play;Population;Prefrontal Cortex;Process;profiles in patients;Reuniens Thalamic Nucleus;Risk;Risk Factors;Role;Site;social;Subgroup;Subthalamic structure;Symptom Burden;Symptoms;Synapses;Testing;Thalamic structure;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Hyperactivity of the thalamo-hippocampal-prefrontal circuit as a mechanism for anxiety in Alzheimer disease - Resubmission - 1

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Nutrition;Obesity;Prevention;Primary Health Care;Sleep Research;Social Determinants of Health

PHR: PROJECT NARRATIVE An unexamined yet promising pathway through which insomnia may promote cardiovascular disease (CVD) is unhealthy eating behaviors such as emotional eating, external eating, restrained eating, poor diet quality, and night eating. This ancillary study to the SHADES mechanistic trial will examine whether unhealthy eating behaviors explain the links between sleep metrics reflecting poor sleep and biomarkers reflecting elevated CVD risk. This study could identify novel targets (specific unhealthy eating behaviors) for future interventions designed to lower the CVD risk in people with insomnia.

PI_NAMEs: STEWART, JESSE C (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adult;Affect;Age;Ancillary Study;Attention;Behavioral Mechanisms;Biological;Biological Markers;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;career;Clinical Psychology;Conditioned Insomnia;Conduct Clinical Trials;cost;Data;design;Development;Disparity population;Doctor of Philosophy;Dyslipidemias;Eating;Eating Behavior;effective intervention;emotional eating;Ethnic Population;Event;experience;Federally Qualified Health Center;Funding;Future;genome wide association study;Glycosylated hemoglobin A;Goals;graduate student;Health;health disparity;Healthcare Systems;Insulin Resistance;interest;Intervention;Knowledge;Leadership;Link;Literature;Mediating;Mediator;men;Mentorship;next generation;novel;parent project;Parents;Pathway interactions;Persons;poor sleep;Prevention;Prevention strategy;primary care patient;primary care setting;programs;psychologic;Psychosocial Factor;Qualifying;Race;racial population;Reporting;Research;Research Personnel;restraint;Risk;Risk Factors;safety net;Sampling;Science;screening;sex;skills;Sleep;Sleep disturbances;sleep onset;Sleeplessness;sociodemographic factors;sociodemographic group;Socioeconomic Status;Symptoms;Testing;therapy design;Training;Unhealthy Diet;Vulnerable Populations;waist circumference;Woman

PROJECT_TITLE: Relationships Among Sleep Parameters, Eating Behaviors, and Cardiovascular Disease Risk Biomarkers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Alzheimer's Disease (AD) is rapidly transforming into a significant economic and social challenge. This proposal will develop and apply advanced AI models to study Alzheimer’s Disease, including the effects of race, comorbidity, and social determinant of health on Alzheimer’s Disease as well as identifying cerebrospinal fluid proteins that are predictive of cognitive decline. Successful completion of this study will provide improved and fair AI models that can be further developed into effective clinical decision support tools as well as enhance our understanding of the pathophysiology of AD.

PI_NAMEs: LAH, JAMES J;QIU, DEQIANG  (contact);ZHAO, LIANG

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Address;African American population;Age;Aging;Alzheimer's Disease;Alzheimer's disease therapeutic;American;Amyloid;Amyloid Proteins;Artificial Intelligence;artificial intelligence method;artificial intelligence model;biobank;Brain;brain health;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;clinical decision support;Clinical Decision Support Systems;Cognitive;community engagement;comorbidity;connectome;convolutional neural network;Data;data integration;deep learning;Dementia;Deposition;Development;Diagnosis;disease diagnosis;disease prognosis;Economics;explainable artificial intelligence;Functional disorder;generative artificial intelligence;Goals;graph neural network;Health Expenditures;hospice environment;Human;Impaired cognition;improved;Lead;Learning;Long-Term Care;Longitudinal cohort;Magnetic Resonance Imaging;Medical Imaging;Methods;mild cognitive impairment;Modeling;multidimensional data;multimodal data;multimodal fusion;neuroimaging;novel;patient prognosis;Patients;Pattern;Phenotype;Positioning Attribute;Positron-Emission Tomography;predictive modeling;Predictive Value;Prognosis;Proteomics;Race;racial difference;Research;responsible artificial intelligence;Role;Services;sex;social;social determinants;social health determinants;Study models;support tools;tau Proteins;therapeutically effective;Training;Underrepresented Populations;Visual;Work

PROJECT_TITLE: Explainable and Ethical AI for Studying Alzheimer's Disease

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Alzheimer disease (AD) is a complex neurodegenerative disease. We will develop computational methods to identify dysregulated communications among AD related cell types by analyzing single-cell data from AD postmortem brains, and validate the findings in human iPSC- derived cortical organoids.

PI_NAMEs: LI, BINGSHAN  (contact);WEN, ZHEXING

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abeta synthesis;Affect;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid;Animal Model;antagonist;Astrocytes;Autopsy;Axon;Blood - brain barrier anatomy;Brain;brain cell;candidate validation;cell assembly;Cell Communication;cell type;Cells;cognitive function;Communication;Complex;Computing Methodologies;cytokine;Data;Dementia;Development;Disease;disease phenotype;Disease Progression;Dissection;Endothelial Cells;Etiology;Exhibits;Feedback;Genetic;Genetic Diseases;Genetic Predisposition to Disease;genetic signature;Human;human induced pluripotent stem cells;Impaired cognition;Inflammation;Inflammatory;Lead;Ligands;Link;Memory impairment;Memory Loss;method development;Methods;Microglia;Modeling;Molecular;mouse model;mutant;myelination;Nerve Degeneration;Network-based;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;novel;Oligodendroglia;Organ;Organoids;Pathogenesis;Pathologic;Pericytes;Pharmaceutical Preparations;Phenotype;Property;Research;response;risk variant;Role;Signal Transduction;single cell ATAC-seq;small hairpin RNA;Statistical Methods;tau Proteins;Testing;Therapeutic;therapeutic target;Tissues;trait;translational potential;United States

PROJECT_TITLE: Genetics-informed dissection of human brain cell-cell communication in Alzheimer's disease progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HUNTSVILLE

ORG_NAME: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY

ORG_STATE: AL

PHR: Project Narrative Tau is a protein that can aggregate in the brain and is associated with many neurodegenerative diseases. Reducing the amount of tau protein may prove to be beneficial in the context of neurodegenerative diseases. To aid in developing drugs targeting tau levels, the proposed study will investigate which transcription factors control the expression of the MAPT gene, which codes for tau.

PI_NAMEs: COCHRAN, JESSE N (contact);MYERS, RICHARD M;SWANEY, DANIELLE L

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Adult;Affect;Affinity Chromatography;Age;Alleles;Alzheimer's Disease;Alzheimer's disease model;Antibodies;Antisense Oligonucleotide Therapy;Autopsy;Binding;Binding Sites;Biological Assay;Biology;Brain;brain cell;Cell Separation;cell type;Central Nervous System;ChIP-seq;Clinical Trials;Code;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Set;Disease;disorder risk;DNA;Drug Delivery Systems;Drug Targeting;Environment;experimental study;follow-up;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Individual;Induced pluripotent stem cell derived neurons;interest;Ligands;loss of function mutation;MAPT gene;Mass Spectrum Analysis;Neurodegenerative Disorders;Neurofibrillary Tangles;novel strategies;Nuclear Receptors;Nucleic Acid Regulatory Sequences;Patients;Periodicals;Pharmaceutical Chemistry;Pharmaceutical Preparations;pill;Population;Population Database;Population Genetics;Principal Investigator;Procedures;Process;promoter;Proteins;Proteomics;Recording of previous events;Regulation;Regulatory Element;Repression;Research Personnel;Sampling;small molecule;Specificity;tau expression;tau Proteins;Tauopathies;Technology;Therapeutic;therapeutic target;therapeutically effective;Tissue Microarray;Transcript;transcription factor;Transcriptional Regulation;transcriptome;Validation;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Identification of trans-regulatory elements controlling MAPT transcription


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers the best chance of identifying the nearly two million people in the US who have these conditions and need tailored disease prevention and clinical management. This project will use an Implementation Mapping approach to conduct a needs assessment of ten PGS programs (Aim 1), develop and produce a multicomponent implementation guide (FOCUS toolkit) to facilitate the implementation of PGS programs (Aim 2), and evaluate the FOCUS toolkit using a hybrid stepped wedge cluster randomized trial among 12 sites at various stages of implementing PGS (Aim 3). These findings will provide a standardized approach for programs seeking to strategically implement PGS and support efforts to bring the promise of precision health to all.

PI_NAMEs: ALLEN, CAITLIN GLOECKNER (contact);ROBERTS, MEGAN C.

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Acceleration;access disparities;Address;Administrator;Adoption;Adult;Attention;Cardiovascular Diseases;career;Characteristics;Clinical;Clinical Management;Cluster randomized trial;Communities;Consolidated Framework for Implementation Research;contextual factors;cost;Data;design;Disease;disease-causing mutation;disorder prevention;Engineering;Equity;Evaluation;Familial Hypercholesterolemia;Family;Family member;field study;Genes;genetic counselor;Genetic Services;Genomic medicine;Genomics;Goals;Guidelines;health equity;Healthcare;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;hereditary risk;high risk;high risk population;human centered design;Hybrids;implementation barriers;implementation facilitation;implementation facilitators;implementation framework;implementation process;implementation strategy;improved;Individual;Inequity;Interview;Knowledge;Maps;member;Methods;Morbidity - disease rate;mortality;National Human Genome Research Institute;Needs Assessment;organizational structure;Outcome;Participant;patient population;Patients;Persons;Population;population based;Population Characteristics;Population Growth;population health;Population Heterogeneity;Precision Health;precision medicine;Procedures;Process;programs;Protocols documentation;prototype;Provider;Public Health;rapid growth;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Risk;Scientific Advances and Accomplishments;screening;screening program;Site;Standardization;Strategic vision;Structure;Testing;tool;trial design;Underrepresented Populations;United States National Academy of Sciences

PROJECT_TITLE: Facilitating the Implementation of Population-wide Genomic Screening across Diverse Populations and Settings (FOCUS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M4)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative This study is significant for public health as it investigates the potential link between poor oral health and incident dementia, specifically Alzheimer’s disease and vascular dementia. Understanding the underlying biological mechanisms and social determinants in these relationships could reveal new strategies for preventing or delaying dementia onset. The study's findings could lead to improved public health policies and clinical practices, emphasizing oral health as a key component in maintaining cognitive health, especially among the increasing aging population.

PI_NAMEs: LUO, HUABIN ;WU, BEI  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: abeta accumulation;Address;Age;age acceleration;Aging;aging biomarker;aging population;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;amyloid formation;Bacteria;Baltimore;biobank;Biological;Biological Aging;Biological Testing;Blood flow;Blood Vessels;Brain;cerebral atrophy;Cerebrospinal Fluid;clinical biomarkers;clinical diagnosis;clinical practice;Cognitive;Cognitive deficits;Data;Data Set;Dementia;dementia risk;DNA Methylation;dysbiosis;Early Diagnosis;Economically Deprived Population;Epidemiology;ethnic minority;ethnic minority population;Ethnic Origin;Face;Female;Generations;Genetic;Genetic Counseling;genome wide association study;Health;Health and Retirement Study;Health Policy;Impaired cognition;improved;Individual;insight;Intervention;Knowledge;Link;Longitudinal Studies;Measures;Mediating;Medicare claim;member;modifiable risk;National Health and Nutrition Examination Survey;Neurofibrillary Tangles;older adult;Oral health;oral microbiome;Pathway interactions;Periodontal Diseases;Periodontitis;poor communities;Population;population based;Poverty Areas;prevent;Prevention;Public Health;racial diversity;racial minority;racial minority population;Research;Risk;Risk Factors;Sampling;screening;Senile Plaques;social determinants;social health determinants;Social isolation;Social support;socioeconomic disadvantage;systemic inflammatory response;tau Proteins;Testing;Tooth Loss;Vascular Dementia

PROJECT_TITLE: Elucidating the Link Between Oral Health and Dementia Subtypes: A Multifaceted Study on the Biological Pathways and Social Determinants

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) The brain extracellular matrix (ECM) plays critical roles in synaptic function remodeling its structure to enable plasticity. We propose to determine if an amyloid-based mechanism, including cystatin-related epididymal spermatogenic (CRES) subgroup amyloids, is integral for the remodeling process allowing sex-specific adaptive changes in a seconds to minutes timescale. Our studies will benefit the neuroscience community broadly by identifying new structural elements in the brain ECM and suggesting novel mechanisms for adaptive functions.

PI_NAMEs: CORNWALL, GAIL A (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Age;Age Months;Alzheimer's Disease;Amyloid;Appearance;Astrocytes;Behavior;Behavioral;behavioral study;beta pleated sheet;Biochemical;Biological;biophysical techniques;Biophysics;Brain;Brothers;Characteristics;Chondroitin Sulfate Proteoglycan;Cognitive;Communities;Cystatins;Data;Diffuse;DNA;Elements;Epididymis;Exhibits;experience;Exposure to;extracellular;Extracellular Matrix;Extracellular Structure;Family member;Female;flexibility;fluorescence imaging;functional plasticity;Future;Hippocampus;Host Defense;Human;human female;Impairment;In Vitro;Infrastructure;Knockout Mice;Knowledge;Liquid substance;male;member;Modeling;Molecular;molecular mass;molecular modeling;monomer;Morphology;mouse model;Mus;Negative Staining;Neurons;Neurosciences;novel;Nucleic Acids;Pathology;Pattern;Peptide Hydrolases;Play;Population;Process;Protocols documentation;public health relevance;Reagent;reproductive tract;response;Reversal Learning;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;sex;Sex Differences;sperm cell;Stains;Structure;Subgroup;synaptic function;Synaptic plasticity;Thioflavin S;Tissues;Urea;Work;X ray diffraction analysis

PROJECT_TITLE: Biological Amyloids in the Mammalian Brain Extracellular Matrix

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SILVER SPRING

ORG_NAME: CENTER FOR CONSTRUCTION RES AND TRAINING

PHR: Project Narrative: The Overall National Construction Center (Center) is comprised of the Planning, Administration and Evaluation (PAE) Core, which manages and coordinates all Center research projects and activities, and four operating cores, Data Core, r2p Core, Communications (COE) Core and Applied Research Core. Each of these core functions, in addition to the nine research projects housed within the Applied Research Core, respond to NORA 3 Construction Sector priorities, NIOSH strategic goals, and the 2018 NIOSH Construction Expert Panel Review. All findings from these projects and activities will be shared broadly through our extensive network of industry partnerships and outreach channels housed within the r2p Core and COE Core.

PI_NAMEs: CAIN, CHRISTINA TRAHAN (contact)

PROGRAM_OFFICER_NAME: CHIOU, SHARON

PROJECT_TITLE: National Center for Construction Safety and Health Research and Translation

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 DH (09)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Recent studies have substantiated role of Eph receptors for the dysfunction of the BBB, as reported in the process of invasion of pathogenic organisms and the early stages of Alzheimer’s (AD) and other neurodegenerative diseases. Yet, the molecular mechanisms regulating Eph receptor function remain poorly understood. To gain insight into the mechanisms of Eph proteins at the molecular level we aim to identify key residues for domain-domain and domain-membrane interactions and configurational changes, primarily in EphA1 and A2, but also in EphA4, B2. The insights obtained will help the eventual development of diagnostic and therapeutic agents.

PI_NAMEs: BUCK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adaptor Signaling Protein;Adhesions;Affect;Alzheimer's Disease;Amyloid beta-Protein;axon guidance;Behavior;Binding;Biochemical;Biological Assay;Biophysics;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood vessel development;C-terminal;cell motility;Cell surface;Cells;Cellular Membrane;Charge;Cholesterol;Complex;Coupled;Data;diagnostic development;dimer;Dimerization;Disease;Drug resistance;Eph Family Receptors;EphA4 Receptor;experimental study;extracellular;Fibronectin Receptors;Fibronectins;Fluorescence;functional mimics;gamma secretase;INPPL1 gene;insight;Invaded;Ischemic Stroke;Knowledge;Length;Ligands;Lipid Bilayers;Malignant Neoplasms;Maps;Matrix Metalloproteinases;Membrane;membrane model;Methods;migration;mimetics;Molecular;Molecular Conformation;molecular modeling;Mutation;Neoplasm Metastasis;Neurodegenerative Disorders;Neurons;novel;Organism;Pathogenicity;Peptides;Phosphatidylinositol 4,5-Diphosphate;Phosphorylation;Phosphotransferases;Play;preference;Process;Protein Family;Protein Fragment;protein purification;protein structure;Protein Tyrosine Kinase;Proteins;receptor;receptor function;Receptor Protein-Tyrosine Kinases;Reporting;Research;Role;SAM Domain;Serine/Threonine Phosphorylation;Signal Transduction;Specificity;src Homology Region 2 Domain;Stimulus;Structure;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic Agents;Transmembrane Domain;Tyrosine;Vascular Diseases;X-Ray Crystallography

PROJECT_TITLE: Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and  Blood Brain Barrier dysfunction

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative  We aim to extract 25 million Veterans’ electronic health records to identify FDA approved medications as new Alzheimer’s disease (AD) therapies. Real world evidence from the Veterans Affairs Corporate Data Warehouse (VA CDW) will be extracted to guide the therapeutic development using an Alzheimer mouse model.

PI_NAMEs: XIA, WEIMING  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Angiotensin II Receptor;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Animals;Anti-diabetic Drugs;Anti-Hypertensive Agents;Astrocytosis;Autopsy;Benchmarking;Big Data;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;Brain;carvedilol;Cell Nucleus;Cells;Cerebral Amyloid Angiopathy;cerebral microbleeds;Chronic;Clinical;Clinical effectiveness;Cognitive;cohort;comorbidity;Data Analyses;data mining;data warehouse;demographics;Development;differential expression;Edema;Effectiveness;Electronic Health Record;exposed human population;Exposure to;Extravasation;familial Alzheimer disease;fasudil;FDA approved;Funding;Future;Genes;Gliosis;hazard;Healthcare Systems;Hemorrhage;Hippocampus;Human;hypercholesterolemia;Image;Immune;Immunotherapy;Impaired cognition;Impairment;induced pluripotent stem cell;Inflammatory;inhibitor;insight;Losartan;mass spectrometer;Medical Records;Memory impairment;mild cognitive impairment;Mining;Molecular;Molecular Profiling;monocyte;mouse model;multidisciplinary;Mus;Nerve Degeneration;neuroinflammation;Neuronal Differentiation;Neurons;next generation;Onset of illness;Outcome;Pathogenesis;Pathology;Pathway interactions;patient health information;Patients;Peripheral;Pharmaceutical Preparations;Phosphotransferases;Physicians;Population;Positioning Attribute;Preclinical Testing;Productivity;Propranolol;Proteomics;Publications;Publishing;Records;Reporting;rho;side effect;single nucleus RNA-sequencing;small molecule;spheroids;Synapses;Systemic hypertension;tau mutation;tau Proteins;tau-1;Testing;therapeutic development;transcriptome sequencing;transcriptomics;Transgenic Mice;United States Department of Veterans Affairs;valsartan;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Veterans;Veterans Health Administration

PROJECT_TITLE: Big data and small molecules for Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Understanding how specific neurons in a selectively vulnerable region such as the entorhinal cortex are affected is critical to unraveling the mechanisms underlying Alzheimer's disease onset. Using in-vivo single-unit electrophysiology recordings and optogenetics we will identify if excitatory neurons or inhibitory neurons or both are more vulnerable to Alzheimer’s disease pathologies. We will use chemogenetic approach to reduce pathology and restore neuronal function.

PI_NAMEs: HUSSAINI, S. ABID  (contact)

PROJECT_TERMS: abeta accumulation;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Behavior;behavior test;Brain region;cell type;Cells;Clinical;Cognitive deficits;computational neuroscience;Computing Methodologies;Confusion;Data;design;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Diagnostic tests;Disease;Drug Targeting;Electrophysiology (science);entorhinal cortex;excitatory neuron;Functional disorder;functional restoration;Genetic;genetic approach;Goals;Hippocampus;Human;Implant;in vivo;inhibitory neuron;innovation;Interneurons;Investigation;Knock-in;Knock-in Mouse;Maps;Measurement;Medial;Memory;mild cognitive impairment;mouse model;Mus;Neuronal Dysfunction;Neurons;new therapeutic target;novel;novel marker;Onset of illness;optogenetics;Parvalbumins;Pathology;Pharmaceutical Preparations;Population;prevent;Property;Psychometrics;Role;Silicones;Somatostatin;Symptoms;System;tau aggregation;tau Proteins;Techniques;Testing;Therapeutic;therapeutic target;tool;Translating

PROJECT_TITLE: Assessing Neuronal Vulnerability in the Entorhinal Cortex due to Alzheimer's Disease Pathology


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Kidney Disease;Mental Health;Organ Transplantation;Pediatric;Social Determinants of Health;Transplantation

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Reducing ableist discrimination against people with disabilities is one of the most pressing issues faced by the US organ transplant system but, due to the absence of oversight and accountability, we do not know the extent to which the ableism-induced equity gap is narrowing. This proposal will have a high public health impact by providing critical information with direct, actionable, implications for healthcare providers and legislators to further mitigate ableism against people with intellectual or developmental disabilities (IDD) in organ transplantation. This proposal is aligned with the NICHD’s Strategic Plan, as we will evaluate whether existing state laws prohibiting disability-based discrimination in organ transplantation are an “effective solution that meets the need of […] people with intellectual and physical disabilities” and RFA-HD-24-007 in that we will “examine the impact of existing efforts to address ableism (e.g., laws) on the health of individuals” with IDD and the way patient-level factors may mediate the “impacts of ableism on health.”

PI_NAMEs: HAND, BRITTANY NICOLE (contact);SCHENK, AUSTIN

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: ableism;Ableist;Accountability;Address;Adherence;Adoption;Affect;Age;Caring;combat;comorbidity;Data;design;Developmental Disabilities;Dialysis procedure;disability;Disabled Persons;Disabling condition;Discrimination;Disparity;disparity gap;efficacy evaluation;Electronic Health Record;End stage renal failure;Ensure;Equity;Evaluation;Event;Exclusion;experience;Goals;Health;health equity;Health Personnel;Healthcare;improved;Individual;Inequity;Institution;Intellectual functioning disability;Intervention;Kidney;Kidney Transplantation;Knowledge;large scale data;Laws;Life;Measures;Mediating;Medical center;Medicare claim;Modeling;National Institute of Child Health and Human Development;Organ;Organ Transplantation;Outcome;Patients;peer;Persons;physically handicapped;Policies;Policy Analysis;Population;practical application;Process;Provider;Public Health;Records;Sampling;social health determinants;Solid;Statutes and Laws;Strategic Planning;Subgroup;System;systemic intervention;Testing;Time;transplant centers;Transplant Recipients;Transplantation

PROJECT_TITLE: Impact of ableism and state laws designed to mitigate ableism on organ transplant equity for kidney transplant candidates with intellectual or developmental disabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-D (50)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE There is little knowledge available regarding the early detection of Alzheimer's disease (AD) and related dementias (ADRD), the factors that lead some people to develop full blown AD/ADRD, and the biological pathways by which they impact in the body especially in South Asians. We will leverage the ongoing Precision-CARRS Cohort, starting in midlife, to investigate factors associated with early and late AD/ADRD stages and use AI and machine learning to assess early AD/ADRD risk. Our goal is to enhance the understanding of how AD/ADRD to enable personalized and precise AD/ADRD disease prediction and advance prevention and management strategies in the understudied, yet high-risk, South Asian population.

PI_NAMEs: ALLADI, SUVARNA ;LEVEY, ALLAN I;MOHAN, VISWANATHAN ;NARAYAN, KABAYAM M VENKAT (contact);PRABHAKARAN, DORAIRAJ

PROJECT_TERMS: Address;Adult;Age;age acceleration;aged;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Asian population;Assessment tool;Behavioral;biobank;Biological;Biological Markers;Blood Vessels;Brain;brain magnetic resonance imaging;cardiometabolism;Classification;Clinical;Cognition;Cognitive;cognitive change;cognitive testing;cohort;Collection;Complex;Data;Data Analyses;data management;Dementia;dementia risk;Detection;Diabetes Mellitus;Diagnosis;digital;Digital biomarker;Disease;Dyslipidemias;Early Diagnosis;early onset;Enrollment;Epidemic;Epidemiology;Etiology;European;Exhibits;experience;family structure;Female;follow-up;Funding;Genetic;Genetic Risk;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Glial Fibrillary Acidic Protein;Goals;high risk;Hypertension;Image;India;Individual;Infrastructure;Knowledge;Language;late life;Lead;learning network;Life;Life Cycle Stages;Life Style;Linguistics;Link;literate;longitudinal design;Longitudinal Studies;Machine Learning;machine learning prediction;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;middle age;mild cognitive impairment;modifiable risk;multidimensional data;multimodal data;multimodality;Myocardium;National Heart, Lung, and Blood Institute;Natural History;neuroimaging;neuroimaging marker;Neuropsychology;novel;novel marker;Organ;Outcome;Participant;Pathway interactions;Pattern;Persons;Phase;Phenotype;phenotypic data;Plasma;pollutant;Population;population based;pre-clinical;predictive modeling;predictive tools;Predisposition;prevent;Prevention;preventive intervention;Protocols documentation;Research;Retina;retinal imaging;Risk;Risk Factors;risk prediction;Sampling;Sleep;Social Behavior;social culture;social structure;sociodemographics;South Asian;Span 20;Spectrum Analysis;Standardization;Statistical Methods;Stress;Stroke;System;Therapeutic;Vascular Cognitive Impairment;Vascular Dementia;whole genome

PROJECT_TITLE: P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India