ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Estrogen;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: NARRATIVE The overarching goal of our continued program of research is to find a safe and effective medication to prevent or treat retinal neurodegeneration that leads to diminished vision or even blindness. This application for renewal addresses whether the estrogen-deprived male and female retinas are especially vulnerable to neurodegeneration, and our topically applied prodrug restricting estrogen’s action to the target site could be a preventative and/or curative pharmacological intervention. Ocular neuroprotection is a pressing unmet medical need, as irreversible retinal neurodegeneration is a fundamental pathological feature of several blinding eye diseases such as glaucoma.

PI_NAMEs: PROKAI, KATALIN T (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Affect;Age;aged;Animal Model;animal old age;Animals;Apoptosis;attenuation;Bioinformatics;Biological Markers;Blindness;Complement;Contrast Sensitivity;Coupled;Data;Data Analyses;deprivation;design;Disease;Electrophysiology (science);Estradiol;estrogenic;Estrogens;Exhibits;Experimental Designs;Eye;Eye diseases;Eyedrops;Female;Functional disorder;Glaucoma;Goals;Grant;Health;Hormonal;Hormones;human model;innovation;insight;Intervention;juvenile animal;Knowledge;male;Medical;Metabolic;metabolomics;Modeling;multiple omics;Nature;Nerve Degeneration;Neural Retina;Neurodegenerative Disorders;neuroprotection;Neuroprotective Agents;normotensive;novel;Ocular Hypertension;Orchiectomy;Oryctolagus cuniculus;Pathologic;Pathology;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phosphoproteins;phosphoproteomics;Physiologic Intraocular Pressure;pre-clinical;preservation;prevent;Prevention;Prodrugs;programs;protein expression;Proteins;Proteome;Proteomics;Rattus;Regulation;Research;Rest;Retina;Retinal Ganglion Cells;sex;side effect;Signal Transduction;Site;Source;stem;Surveys;Testing;Testosterone;Therapeutic;Therapeutic Agents;therapeutic target;therapy design;Topical application;Translational Research;Vision;Visual Acuity;Visual impairment

PROJECT_TITLE: A Novel Neuroprotective Approach for Glaucoma


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: GRIMSRUD, KRISTIN NICOLE (contact)

PROJECT_TERMS: Acclimatization;Age;animal care;Animal Model;Animals;Area;authority;Autopsy;bariatric surgery;Bariatrics;Behavior;behavioral phenotyping;Biology;Cannulations;Caring;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Communicable Diseases;comorbidity;Comparative Pathology;Complex;Containment;cost;cost effective;Data;Data Collection;Dedications;Derivation procedure;Diabetes Mellitus;Diabetic mouse;Disease;Enrollment;Ensure;Environment;environmental enrichment for laboratory animals;Fee-for-Service Plans;Gender;Generations;Genetic;genetic manipulation;genome editing;germ free condition;Gnotobiotic;Goals;Health;Health Services;Health Status;Histopathology;House mice;Housing;Human Resources;IACUC;Immunohistochemistry;implantation;Individual;insight;Institution;Laboratories;laboratory facility;Maintenance;medical specialties;meetings;Metabolic;metabolic phenotype;Mission;Modeling;Molecular;Monitor;mouse model;Movement;Mus;Obesity;operation;Operative Surgical Procedures;Pathology;Phenotype;Physiological;Privatization;Procedures;Production;programs;public repository;Qualifying;Quarantine;repository;Reproducibility;Research;Research Personnel;Resources;Rodent;Scientist;Service delivery model;Services;Specialist;Students;Surgical Models;Telemetry;Testing;Transgenic Organisms;Veterinarians;Virus;Work

PROJECT_TITLE: Animal Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Asthma;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Pulmonary Fibrosis

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The overall goal of this application is to study lung and peripheral blood immune cells and lipids in asthma patients to identify mechanisms that induce a corticosteroid-refractory inflammatory phenotype that can be targeted to block chronic disease and improve response to therapy thereby preventing stress-induced premature senescence, a phenomenon increasingly being associated with other chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

PI_NAMEs: RAY, ANURADHA  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adult;Allergens;allergic airway disease;Asthma;asthmatic patient;Belief;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Cell Aging;Cells;Child;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Development;disease heterogeneity;Dose;flexibility;Funding;Generations;Glucocorticoid Receptor;Goals;high dimensionality;Human;human old age (65+);idiopathic pulmonary fibrosis;Immune;Immune response;Immune System Diseases;Immunology;improved;in vivo;Inflammaging;Inflammatory;Inhalation;interest;Interferon Type II;Laboratories;Lipids;Literature;Lung;Lung Diseases;Metabolism;mitochondrial dysfunction;Molecular;Molecular Biology;mouse model;multiple omics;new therapeutic target;novel therapeutics;Pathogenesis;Patients;peripheral blood;Phenotype;premature;Premature aging syndrome;prevent;Production;programs;Refractory;Research;response;Scientist;senescence;Side;STAT1 gene;Stress;T-Lymphocyte;targeted treatment;Th2 Cells;Therapeutic;Therapeutic Intervention;tissue resident memory T cell;tool;Training;treatment response

PROJECT_TITLE: Dysregulated Immunometabolism and Premature Senescence in Corticosteroid-Refractory Severe Asthma


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative The immunosuppressive tumor microenvironment (TME) represents a substantial barrier for effective Chimeric Antigen Receptor (CAR)-T cell therapies targeting solid tumors. This research plan describes the development of transformative technologies to elucidate, engineer, and rewire the signaling pathways in CAR-T cells to overcome TME-associated immunosuppressive signals.

PI_NAMEs: ZHOU, XIN  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: 3-Dimensional;Address;Advanced Development;Affect;Affinity;anti-cancer;anti-cancer research;Antigens;Attenuated;Automobile Driving;Binding;Biology;cancer immunotherapy;CAR T cell therapy;Cell Line;Cell Physiology;Cells;Cellular biology;Cellular immunotherapy;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Complex;cytokine;Cytoplasm;Data Analyses;design;Development;Engineering;Environment;Enzymes;Evaluation;Event;exhaustion;Future;Goals;Government;Head;Hematologic Neoplasms;Hematopoietic Neoplasms;Human Engineering;Immune system;Immunosuppression;improved;In Situ;In Vitro;Individual;innovation;inorganic phosphate;Jurkat Cells;Knowledge;Label;Laboratories;Libraries;Ligation;Malignant Neoplasms;Mediating;Mentors;Methods;Modification;mutant;novel;novel strategies;Outcome;Output;Pathway interactions;PD-1 pathway;Persons;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Phosphotyrosine;post-doctoral training;Postdoctoral Fellow;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;Protein Engineering;protein structure;Proteins;Proteomics;rational design;Recombinant Antibody;Recombinants;recruit;Research;Resistance;response;Safety;screening;Signal Pathway;Signal Transduction;Signaling Protein;skills;Solid Neoplasm;Specificity;Structure;success;synthetic biology;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;tool;Training;translational approach;tumor;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Tyrosine Phosphorylation;Work

PROJECT_TITLE: Interrogating and rewiring cell signaling pathways in CAR-T cells with synthetic phosphotyrosine recognition domains

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: AUGUSTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is providing funds to establish the coordinating unit (CU) for the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD) program. The CU will coordinate the interactions of the MPMOD Phenotyping Centers, provide financial management for the MPMOD Vibrant Program, interact with the Executive Steering Committee and External Scientific Panel as well as provide a national web portal for MPMOD in order to disseminate information and provide an organizational infrastructure for the program. This application will provide the infrastructure for the CU for MPMOD.

PI_NAMEs: MCINDOE, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Agreement;analytical tool;Award;Blood;Businesses;Catalogs;Client;Communication;Communities;Computer Hardware;Computer software;Data;design;Diabetes Mellitus;E-learning;Eating;Educational workshop;energy balance;Exercise;Feedback;Fees;Funding;General Population;Goals;Hormones;informatics infrastructure;Infrastructure;Institution;Maintenance;meetings;member;metabolic phenotype;Metabolism;Mission;Modeling;Morphology;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;Occupational activity of managing finances;operation;Organ;outreach;Phenotype;Physiology;Process;programs;Records;Reporting;Research Activity;Research Personnel;Research Support;Services;Site;software systems;Software Tools;success;symposium;System;Technology;Teleconferences;Testing;Time;Training;Travel;United States National Institutes of Health;Visualization software;web portal;web site;web-based tool

PROJECT_TITLE: Coordinating Unit for the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD)


PI_NAMEs: ADAMS, SEAN HARRISON (contact)

PROJECT_TERMS: Acute;Address;Animals;Applications Grants;Area;Behavior;Bioenergetics;Biological Assay;Biomedical Research;Body Composition;Catalogs;Client;Clinical Trials;Collaborations;Complement;Complex;complex data;Consultations;Continuous Glucose Monitor;Core Assembly;Coupled;Coupling;Data;Data Set;design;Diabetes Mellitus;Digestion;Dual-Energy X-Ray Absorptiometry;Eating;energy balance;Energy Intake;Energy Metabolism;Equipment;Exercise;Expenditure;experience;experimental study;extreme temperature;feeding;Feeding behaviors;Female;flexibility;Frequencies;frontier;Functional disorder;Generations;Glucose;glucose metabolism;glucose tolerance;Goals;gut microbiome;gut microbiota;Health;Hepatic;Homeostasis;hormone sensitivity;Hormones;Human;in vivo;Infrastructure;innovation;Institution;instrumentation;Insulin Resistance;interest;Link;Lipids;Macronutrients Nutrition;male;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic hormone;metabolic phenotype;Metabolism;metabolomics;Methods;microbiome;Mission;Modeling;Molecular;mouse model;Mus;Norepinephrine;Obesity;Outcome;Participant;Pattern;Phenotype;Physiology;Play;pre-clinical;Procedures;Production;programs;Publications;Regulation;Reproducibility;Research;Research Design;Research Personnel;Role;Scientist;Services;Signal Transduction;Specialist;Structure;Techniques;Testing;Tissues;Training;Triglyceride Metabolism;Triglycerides;Weight Gain;whole body imaging;Work

PROJECT_TITLE: Metabolism and Metabolic Health Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Bioengineering;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Discovery of the genetic factors involved in brain communication and brain connectivity that contribute to PTSD may prove vital to new treatment breakthroughs. The coupling of brain connectivity with its genetic architecture, mapping the neurogenetic pathways of PTSD, and new knowledge of neural and genetic mechanisms will support precision-medicine guided drug discovery for managing mental illnesses that follow psychological trauma.

PI_NAMEs: LOGUE, MARK W;MOREY, RAJENDRA A (contact);NIEVERGELT, CAROLINE M

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Address;Africa;analysis pipeline;Architecture;Area;Asia;Attention;Australia;Award;Behavioral;Brain;cloud based;cohort;Collaborations;Communication;Communities;Coupling;Data;data framework;data infrastructure;Data Set;data sharing;Decentralization;design;Development;Diagnosis;Diagnostic;Dimensions;drug discovery;Europe;experience;Functional Magnetic Resonance Imaging;Funding;Future;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Transcription;genome wide association study;Genomics;Genotype;Goals;Heritability;high dimensionality;independent component analysis;innovation;Institution;instrument;International;Knowledge;Lateral;Letters;Link;Maps;Mental disorders;Methods;Modeling;network models;neural;neurogenetics;neuroimaging;Neurosciences;North America;outreach;Paper;Pathway interactions;Patients;Pattern;Peer Review;Phenotype;Post-Traumatic Stress Disorders;precision medicine;Process;Progress Reports;psychological trauma;Publishing;Research;Research Personnel;Rest;Role;Sampling;Severities;Signal Transduction;Site;spatiotemporal;Structure;Surface;symptom cluster;Symptoms;targeted treatment;Testing;Thick;Trauma;trauma exposure

PROJECT_TITLE: Genomic Architecture of Functional Brain Networks in PTSD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Genetic mutations do not fully explain metastatic behavior. We are studying the contribution of the non-coding genome – and particularly of a novel RNA species, circular RNA (circRNA) – to melanoma metastasis. The objectives of this proposal are to genetically demonstrate CDR1as’ metastasis suppressive role and to dissect the biological effects and downstream mediators of CDR1as loss in melanoma progression.

PI_NAMEs: HERNANDO, EVA  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Affect;Anti-sense RNA;Automobile Driving;Behavior;Binding;Binding Sites;Biochemical;Biogenesis;Biological;Biological Process;Biology;Cancer Patient;cancer type;Cause of Death;Cell Line;Cell Physiology;Cells;Cellular Assay;Cerebellar Degeneration Related 1 Antisense;circular RNA;clinically relevant;Code;Cutaneous Melanoma;Data;Disease;DNA Sequence Alteration;Family;Gene Expression;Genes;Genetically Engineered Mouse;Genome;Glioma;Goals;Histologic;Human;Immunocompetent;In Vitro;in vivo;Incidence;inhibitor;Invaded;Knockout Mice;Knowledge;Ligation;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Melanoma;Melanoma Cell;Melanoma patient;member;Messenger RNA;Metastatic Melanoma;MicroRNAs;migration;Modeling;Molecular;mouse model;mRNA Stability;mRNA Translation;Neoplasm Metastasis;Neurons;new therapeutic target;novel;oncofetal antigen;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;Phenotype;Physiology;Primary Neoplasm;Proteins;Proteomics;Publications;Regulation;Regulator Genes;ribosome profiling;RNA;RNA-Binding Proteins;Role;small hairpin RNA;Therapeutic;Tissues;Transcript;transcriptome sequencing;transcriptomics;tumor;tumor behavior;tumor microenvironment;tumorigenesis;tumorigenic;Untranslated RNA;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of circular RNA CDR1as in melanoma

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Sleep Research

PI_NAMEs: SILVERMAN, JILL LYNN (contact)

PROJECT_TERMS: Address;Affective;Animals;Anxiety;Apnea;Applications Grants;Area;Attention;Behavior;behavior test;Behavioral;behavioral phenotyping;Biological Assay;Biomedical Research;Body System;Breeding;cancer type;Cardiovascular Physiology;Chronic;Chronic Kidney Failure;Client;Clinical Trials;Cognition;cohort;Communities;Complement;Complex;Consultations;Data;Degenerative polyarthritis;Dementia;Development;Diabetes Mellitus;Disease;energy balance;Ensure;Equilibrium;Event;executive function;Exercise;Female;flexibility;Gait;gastrointestinal function;Generations;Genetic;Genotype;Health;Health system;Heart Diseases;Heterogeneity;Human;Hyperglycemia;Hypertension;Image;Immune;in vivo;in vivo evaluation;Inflammation;innovation;Insulin Resistance;intestinal barrier;Laboratories;Learning;male;Memory;Mental Depression;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;Mission;Monitor;Motor;motor disorder;mouse model;Mus;mutant;Neurologic Symptoms;Neuropathy;neurophysiology;Nociception;non-alcoholic fatty liver disease;Obesity;Outcome Measure;Pain;Participant;Patients;Phenotype;Physiological;Physiology;pre-clinical;pre-clinical research;Procedures;programs;Publications;Recommendation;Renal function;Reproducibility;Research;Research Design;Research Personnel;Resources;Respiratory physiology;Retinal Diseases;Risk Factors;Scientist;Services;sex;sex as a biological variable;sexual dimorphism;Sleep;Sleep Deprivation;Sleep Stages;Social Behavior;Specialist;Technology;Testing;tool;Training;training opportunity;wound healing

PROJECT_TITLE: Physiology and Behavior Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Clonal hematopoiesis, a condition where stem cells of the blood acquire mutations and experience increased rates of division, is a relatively common phenomenon, with an incidence of over 10% in patients over the age of 65. Importantly, while patients with clonal hematopoiesis do not experience any symptoms as a result of these mutations, they are at significantly increased risk for developing blood cancers and cardiovascular disease. Using genetic analysis that permits identification of these mutations in single cells, and therefore resolving the admixture of wild type and mutant cells within a sample, this project aims to uncover the processes by which clonal hematopoiesis develops into more serious disease.

PI_NAMEs: DUSAJ, NEVILLE  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute Myelocytic Leukemia;Admixture;Age;Aging;Binding;Biological;Blood;Blood Cells;Blood specimen;Bone Marrow;Cardiovascular Diseases;cardiovascular health;Cell Physiology;Cells;Chromatin;Clinical;Clonal Evolution;Clonal Expansion;Data;Development;differential expression;Disease;Disease Progression;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3a mutation;Doctor of Philosophy;Dysmyelopoietic Syndromes;experience;Fellowship;fitness;Gene Expression;Genes;genetic analysis;Genetic Fingerprintings;Genetic Transcription;genome wide methylation;genome-wide;Genotype;Goals;Growth;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;Hematopoietic stem cells;Human;human old age (65+);Incidence;Individual;Inflammatory;insight;Joints;Lead;Leadership;Link;loss of function;Macrophage;Malignant Neoplasms;Maps;Measurement;Mentorship;Methods;Methylation;methylome;monocyte;multimodality;multiple omics;mutant;Mutate;Mutation;neoplastic;novel;novel sequencing technology;Nucleic Acid Regulatory Sequences;Outcome;Outcome Study;Pathogenesis;Pathway interactions;patient variability;Patients;Pattern;peripheral blood;Physicians;Polycomb;Precancerous Conditions;Prevalence;prevent;Process;programs;protein complex;Recommendation;Regulatory Element;Research Personnel;Resolution;Risk;Role;Sampling;Scientist;screening;screening guidelines;single cell sequencing;Somatic Mutation;stem cells;Symptoms;Technology;Testing;Therapeutic;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Deciphering Clonal Hematopoiesis via Single-Cell Multi-omics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Neurosciences;Nutrition

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Our group as discovered that focused ultrasound stimulation targeted to sensory neurons located at the hepatic portal vein and other sites within the GI tract has the capacity to restore glucose homeostasis in pre- clinical models of type 2 diabetes. Under this proposal we are using hyperinsulinemic-euglycemic clamps, oral glucose tolerance testing and stable isotope NMR imaging methods to characterize the effect of focused ultra- sound treatments targeted towards different afferent sensory fields on insulin sensitivity and hepatic glycogen storage; thereby contributing to normalization of glucose levels in recently diagnosed type 2 diabetic subjects. If confirmed our studies will help establish neuromodulation via focused ultrasound not only as a new tool to interrogate regulation of human glucose homeostasis, but also as a potential non-pharmacologic treatment modality for diabetes.

PI_NAMEs: HERZOG, RAIMUND INGO (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Abdomen;Acute;Address;Affect;Afferent Neurons;alternative treatment;Animal Model;Animals;Area;Autonomic nervous system;Autonomic Pathways;blood glucose regulation;Brain;Brain Stem;Carbon;Cell Nucleus;cell type;Cells;Central Nervous System;Circulation;Clinical;Clinical Data;Clinical Research;clinical translation;Closure by clamp;Data;Denervation;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diagnosis;Distal;euglycemia;experimental study;feeding;Focused Ultrasound;Focused Ultrasound Therapy;gastrointestinal;Gastrointestinal tract structure;Genetic;ghrelin;Glucagon;glucagon-like peptide 1;Glucose;Glucose Clamp;glucose disposal;glucose metabolism;glucose sensor;glucose tolerance;glycemic control;Glycogen;Hepatic;Hepatology;Homeostasis;Hormones;Human;human subject;Hyperglycemia;Hyperinsulinism;Hypothalamic structure;imaging modality;Individual;Ingestion;innovation;Insulin;Insulin Resistance;insulin sensitivity;Investigation;Ion Channel;Link;Liver Glycogen;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Mediator;Mesentery;Metabolic;Methods;Microelectrodes;Modality;Modeling;Molecular;Mus;Nerve;Nerve Fibers;Nerve Plexus;Nervous System;neural circuit;Neuroendocrinology;Neurons;neuroregulation;Newly Diagnosed;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;novel;Nutrient;OGTT;optogenetics;Patients;Peripheral;Physiologic pulse;Pilot Projects;Play;Portal vein structure;pre-clinical;Pre-Clinical Model;preclinical study;Reflex action;Reflex control;Regulation;Resistance;response;Rodent Model;Role;Scientist;sensor;Sensory;Signal Transduction;Site;skills;stable isotope;synergism;Testing;Therapeutic Effect;therapeutic target;Time;tool;Tracer;Transgenic Organisms;translational study;treatment site;Type 2 diabetic;ultrasound;Uncertainty;Validation;Work

PROJECT_TITLE: Mechanism of ultrasound neuromodulation effects on glucose homeostasis and diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TOLEDO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative Brain and cerebrovascular phenotypes in Alzheimer's disease (AD) have not been proportionally studied. The primary goal of proposal is to understand the molecular mechanisms of cerebrovascular disease from a novel perspective of cilia biology.

PI_NAMEs: ABOUALAIWI, WISSAM  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;abeta deposition;Acetylcholine;Affect;Age Months;aged;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;Amyloid beta-Protein;amyloid pathology;Anabolism;Animal Model;Attenuated;Biology;blood pressure regulation;Blood Vessels;Brain;brain endothelial cell;Cardiovascular system;Cell model;Cerebral Amyloid Angiopathy;cerebral artery;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;cholinergic;Cilia;ciliopathy;cilium biogenesis;Cilium Microtubule;Cognition;Cognitive;cognitive function;Cues;Data;defined contribution;Deposition;design;Development;Disease;Disease Progression;Endothelium;Environment;environmental change;extracellular;Functional disorder;Genetic Diseases;Goals;Histologic;Human;Hypertension;hypertension treatment;Impaired cognition;Impairment;in vivo;Incidence;Intuition;Investigation;Knockout Mice;Knowledge;Learning;Length;Link;Liquid substance;Mechanical Stress;Mechanics;Mediating;Memory;Memory impairment;Microcirculation;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;Muscarinic Acetylcholine Receptor;mutant;neuroinflammation;Neurons;neuroprotection;neurovascular injury;neurovascular unit;new therapeutic target;Nitric Oxide;Nitric Oxide Pathway;novel;Organelles;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;Play;prevent;Process;Production;receptor;Receptor Activation;Receptor Signaling;Research;response;Risk;Role;Sampling;Sensory;shear stress;Signal Pathway;Signal Transduction;Structure;Surface;Symptoms;System;Testing;therapeutic target;therapy design;transcriptional reprogramming;translational impact;transmission process;Vascular blood supply;Vascular Cognitive Impairment;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;vascular factor

PROJECT_TITLE: Cerebrovascular endothelial cilia in the pathogenesis and therapy of Alzheimer's disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Cerebral blood flow (CBF) measures cerebrovascular health and regional brain function and has broad range of applications in both neuroscience and clinical care. In this Academic Industrial Partnership, neuroimaging investigators from the University of Pennsylvania and the University of Maryland will partner with investigators from Siemens Medical Solutions, USA to develop and disseminate a robust MRI technology that can noninvasively quantify CBF. The methodology is also applicable to studying brain tumors and other organs.

PI_NAMEs: CHANG, YULIN V;DETRE, JOHN A (contact);WANG, ZE

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Academia;Acceleration;Address;Algorithms;arterial spin labeling;Biological;Biological Markers;Biomedical Research;Blood;Blood flow;Body System;Brain;brain health;Brain Neoplasms;Brain region;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;Charge;Clinical;clinical application;clinical care;Clinical Research;Code;cognitive neuroscience;Collaborations;community engagement;Complex;Computer Hardware;Computer software;Consumption;Data;Dedications;deep learning;Development;Diagnosis;Environment;Evaluation;flexibility;Funding Mechanisms;Image;image reconstruction;improved;Industry;industry partner;innovation;Label;Laboratories;Machine Learning;Magnetic Resonance Imaging;Magnetism;Maps;Marketing;Maryland;Measurement;Measures;Medical;Methodology;Methods;Morphologic artifacts;Motion;neural;neuroimaging;Neurosciences;Neurosciences Research;next generation;novel;Organ;Pennsylvania;Perfusion;perfusion imaging;Physiological;Process;prospective;Radiology Specialty;real-time images;reconstruction;Reproducibility;Research;Research Personnel;Resolution;Resources;response;Running;Scheme;Severities;signal processing;Signal Transduction;Site;System;Technology;technology development;temporal measurement;Three-Dimensional Imaging;Time;Tissues;Tracer;Translating;tumor;United States National Institutes of Health;Universities;user-friendly;Vendor;Water;Work

PROJECT_TITLE: Academic Industrial Partnership on Advanced Perfusion MRI


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative We want to study the role of adhesion GPCR ADGRB3 as a tumor suppressor in the formation of medulloblastoma, a malignant brain tumor in children. We found that ADGRB3 gene is silenced in the WNT subgroup of medulloblastoma and that reactivation of its expression by epigenetic means has therapeutic benefits. The knowledge derived from these studies may lead to the development of novel epigenetic therapies for brain cancer through the restoration of the ADGRB3 tumor suppressor pathway function.

PI_NAMEs: VAN MEIR, ERWIN G. (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Adhesions;antagonist;Attenuated;Behavior;beta catenin;Binding;Binding Proteins;bisulfite sequencing;blood-brain barrier permeabilization;Brain;Brain Stem;cell growth;Cell Proliferation;cell transformation;Cells;Central Nervous System;Central Nervous System Neoplasms;Cerebellar Neoplasms;Cerebellum;chemotherapy;Child;Childhood Brain Neoplasm;Chromatin;Clinical;Clinical Trials;Cognitive;Combination Drug Therapy;CpG Islands;CRISPR/Cas technology;CTNNB1 gene;Data;Data Set;design;Development;developmental neurobiology;DNA Methylation;DNA-Binding Proteins;Dorsal;Epigenetic Process;epigenetic regulation;epigenetic therapy;experimental study;EZH2 gene;G-Protein-Coupled Receptors;Gene Activation;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Growth;Hippocampus;histone methyltransferase;histone modification;Human;In Vitro;in vivo;inhibitor;insight;Intellectual functioning disability;Knockout Mice;Knowledge;Lip structure;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;MBD2 protein;Mediating;Medulloblastoma;medulloblastoma cell line;member;Methylation;Molecular Profiling;molecular subtypes;Monitor;Morbidity - disease rate;Morphogenesis;mRNA Expression;Mus;mutant;myogenesis;nerve stem cell;Neurologic;Neurological disability;Neurons;Neurosecretory Systems;neurosurgery;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Oncogenic;Operative Surgical Procedures;Orphan;Outcome Study;Pathway interactions;Patients;Pediatric Neoplasm;pharmacologic;Phosphorylation;physically handicapped;Physiological;Predisposition;promoter;Property;Protein Methyltransferases;Protein Microchips;PTEN gene;Radiation;Radiation therapy;receptor;Regulation;Repression;restoration;Reverse Transcriptase Polymerase Chain Reaction;Role;Scaffolding Protein;Secondary to;Serine;seven-transmembrane G-protein-coupled receptor;SHH gene;side effect;Signal Pathway;Signal Transduction;small molecule;Subgroup;Survival Rate;Survivors;Synaptic plasticity;synaptogenesis;System;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutically effective;Tissues;transcriptome sequencing;Transgenic Mice;Translations;Treatment Side Effects;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenic;Tumorigenicity;WNT Signaling Pathway;Xenograft procedure;young adult

PROJECT_TITLE: Evaluating ADGRB3 as a tumor suppressor epigenetically silenced in WNT medulloblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The goal of this R01 project is to understand how nutrient signals, such as arginine, regulate the pancreatic islet alpha cell. We will define the molecular mechanism by which arginine is transported and sensed in alpha cells and how this stimulates glucagon secretion and α cell proliferation. Successful completion of this award will identify new targets for the dysregulated glucagon secretion observed in individuals with diabetes that exacerbates hyperglycemia.

PI_NAMEs: DEAN, ERIKA DANIELLE (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acids;Acute;Affect;Affinity;Alpha Cell;Amino Acid Transporter;Amino Acids;Arginine;Award;Basic Amino Acid Transport Systems;Beta Cell;Binding;Binding Proteins;Blood;Blood Glucose;blood glucose regulation;Blood specimen;Catabolism;Cations;Cell membrane;Cell Physiology;Cell Proliferation;Cell secretion;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Cellular biology;Complex;Data;Development;Diabetes Mellitus;Diet;Endocrine;Enzymes;Essential Amino Acids;extracellular;Feedback;feeding;Fishes;Funding;Gene Expression;Gene Targeting;Glucagon;Glucagon Receptor;Gluconeogenesis;Glutamine;Goals;Hepatic;hepatic gluconeogenesis;hepatic ureagenesis;Human;hyperglucagonemia;Hyperglycemia;Hyperplasia;Impairment;improved;Individual;insight;Insulin;Interruption;Investigation;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;Knockout Mice;Leucine;live cell imaging;Liver;man;Measures;Mediator;member;Membrane;Modeling;Molecular;Monitor;Mus;Names;Nature;novel;novel therapeutic intervention;Nutrient;overexpression;pancreatic juice;Play;Proliferating;protein expression;Proteins;Regulation;repaired;response;Role;sensor;Signal Transduction;stem;Structure of alpha Cell of islet;targeted treatment;Tertiary Protein Structure;Testing;transcriptomics;Translating;type I and type II diabetes;Work

PROJECT_TITLE: Arginine regulation of alpha cell proliferation and function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative: The study will determine the combined and synergistic effects of a family-based economic empowerment and gender equality intervention on young adolescents’ mental health; 2) pathways by which the combined intervention effects adolescent mental health; and 3) differences in the pathways of the combined intervention effects by sex of the young adolescents. The study will inform and provide lessons learned to advance adolescent mental health in conflict-affected areas.

PI_NAMEs: GLASS, NANCY E (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Adolescent;adolescent mental health;Affect;Age;Agreement;Area;arm;Attention;authority;Behavior;boys;Breeding;Caring;Child;child poverty;Child Rearing;Childhood;childhood adversity;Communication;Conflict (Psychology);Couples;Democratic Republic of the Congo;deprivation;design;Discipline;Economics;Education;Educational Curriculum;empowerment;Evidence based intervention;experience;Exposure to;externalizing behavior;Family;Family Relationship;Fathers;Fees;Female Adolescents;Food;food security;Friends;Gender;gender equality;gender equity;girls;Goat;Health;Home;Household;Housing;Husband;improved;Inequality;Inequity;Intervention;intervention effect;intimate partner violence;Investments;Knowledge;male;Male Adolescents;Medical;Mental Depression;mental function;Mental Health;Mentors;Mentorship;Mothers;multidisciplinary;offspring;Oryctolagus cuniculus;outcome disparities;parenting intervention;Parents;Pathway interactions;Patient Self-Report;peer;Persons;Politics;Post-Traumatic Stress Disorders;Poverty;Program Sustainability;programs;Province;Punishment;Randomized, Controlled Trials;Reporting;resilience;Rural;rural area;rural residence;Rwanda;Schools;Self Efficacy;sex;sexual violence;Shock;skills;social norm;social stigma;Symptoms;Testing;Trauma;trauma exposure;UNICEF;Victimization;Violence;violence perpetration;violence victimization;Water;Wife;Woman;Work;Youth

PROJECT_TITLE: Pathways to improved adolescent mental health via an economic and gender equality intervention with conflict affected families


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Alzheimer’s disease (AD) is a dreadful common disease. We will determine the potential contribution of bacteria in the gut to AD and the cognitive decline in the patients with AD and their spouses, and the usefulness of indices in the blood to predict cognitive decline. Thus, the findings from this project may ultimately help the care for patients with AD and the health of their spouses.

PI_NAMEs: FINAN, PATRICK  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acetates;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein Precursor;amyloid peptide;Animals;Antiinflammatory Effect;Attenuated;Biological Markers;biomarker identification;Blood;Brain;Caregivers;caregiving;Cognition;Cognitive;cytokine;Data;Dementia;Dementia caregivers;dementia risk;Development;Disease;Disease Outcome;Elderly;Environment;Event;extracellular;Functional disorder;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;Health;Healthcare;high risk;Human;hyperphosphorylated tau;Impaired cognition;Impairment;improved;indexing;Inflammation;Inflammatory;Inflammatory Response;Knowledge;Learning;Life;Mediator;Memory;Memory impairment;microbiome alteration;Mus;n-pentanoic acid;Neurofibrillary Tangles;neuroinflammation;Neuronal Injury;neuropathology;neurotoxicity;Operative Surgical Procedures;Participant;Partner in relationship;Pathologic;Pathologic Processes;Patient Care;Patients;Positron-Emission Tomography;potential biomarker;preclinical study;recruit;Reporting;Role;Senile Plaques;Spouse Caregiver;Spouses;Stress;tau Proteins;Time;Volatile Fatty Acids;Wild Type Mouse

PROJECT_TITLE: Gut microbiome and blood indices in patients with AD and their spousal caregivers

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: This grant application seeks to understand the role of a recently discovered new mechanism of cap-dependent mRNA translation that is essential for breast cancer metastasis in animal models. Based on our research, we propose to understand the role of the new DAP5/eIF3d mechanism in metastasis and its mechanism of action.!

PI_NAMEs: SCHNEIDER, ROBERT JAY (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Aftercare;Animal Model;Apoptosis;Applications Grants;Automobile Driving;Binding;Binding Sites;Biopsy;Blood Vessels;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;cancer cell;Cancer Control;Cell Line;Cells;Complex;conditional knockout;Data;Development;epithelial to mesenchymal transition;Extravasation;Gene Modified;genome-wide;Homologous Gene;Human;Immune;Impairment;in vivo;Invaded;Knockout Mice;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;member;Messenger RNA;Methylation;migration;Modeling;Modification;molecular marker;mRNA Translation;Mus;Neoplasm Metastasis;neoplastic cell;Oncogenic;Paraffin Embedding;Pathway interactions;patient derived xenograft model;Patients;Peptide Initiation Factors;Phenotype;power analysis;Prevention;Primary Neoplasm;Proteins;Recurrence;Research;Role;Site;targeted biomarker;Testing;Tissues;transcriptomics;Translating;Translation Initiation;Translational Regulation;Translations;triple-negative invasive breast carcinoma;tumor;tumor initiation;tumor progression;Xenograft procedure

PROJECT_TITLE: DAP5-dependent translational control and breast cancer metastasis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences;Nutrition;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: UROLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative: Urinary urgency incontinence is a major public health concern affecting over 40 million people, primarily women, in the United States alone. Our understanding of how and why urgency incontinence develops is incomplete which prevents efficient diagnosis and treatment. The results of this study will not only fill a significant knowledge gap in understanding the etiology of UUI, but will provide a potential method of differentiating phenotypes of UUI and potential targets for intervention.

PI_NAMEs: SHEYN, DAVID  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acetylcholine;Affect;age related;aging process;Amines;Anxiety;Bladder;Bladder Control;Body System;Brain;Cardiovascular Diseases;Central Nervous System;Characteristics;Choline;choline deficient diet;Choline O-Acetyltransferase;cholinergic;Classification;Clinical;Coenzymes;comparison control;Data;detrusor muscle;Development;Diagnosis;Diet;dietary;Dietary intake;differential expression;Disease;disorder risk;Early Intervention;egg;Enzymes;Esthesia;Etiology;Evaluation;Fishes;Food;Functional disorder;Genetic;genetic analysis;Genetic Markers;genomic data;human old age (65+);improved;Incidence;Incontinence;individualized medicine;Intake;Intervention;Kidney Diseases;Knowledge;Lead;Lecithin;Link;Measures;Meat;Mental Depression;Metabolic;Metabolic Marker;metabolic profile;Metabolism;metabolomics;Methods;micturition urgency;Mus;Nervous System;Neurologic;Neurons;neuroregulation;neurotransmission;Neurotransmitters;non-alcoholic fatty liver;novel;Nurses' Health Study;Nutrient;older women;Onset of illness;Organ;Oxides;Pathway interactions;Patients;Pelvic floor structure;Peripheral;Persons;Phenotype;Phosphorylcholine;Plasma;Prevalence;prevent;Prevention strategy;preventive intervention;Prospective cohort;Psychological Stress;Public Health;Quality of life;Reporting;Research;response;Risk;Risk Factors;Serum;Severities;Signal Transduction;Single Nucleotide Polymorphism;Sphingomyelins;System;United States;urinary;Urinary Incontinence;Woman;Women's Health

PROJECT_TITLE: Evaluation of genetic and metabolic markers in the development of urinary urgency incontinence

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Evidence suggests that activators of specific muscarinic acetylcholine receptor (mAChR) subtypes in the brain have exciting potential as novel treatments for positive symptoms, negative symptoms, and cognitive disturbances in patients suffering from schizophrenia. We propose a series of studies aimed at developing a better understanding of the roles of specific mAChR subtypes in brain circuits that may underlie their ability to improve symptoms in schizophrenia patients.

PI_NAMEs: ROOK, JERRI MICHELLE (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: acetylcholine receptor agonist;Address;Adult;Adverse effects;Animal Model;Antipsychotic Agents;associated symptom;Behavior;behavior measurement;Behavioral;behavioral response;Brain;Brain Diseases;cell type;Cells;clinical development;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive function;Coupling;Data;Development;Disease;Electrophysiology (science);Excitatory Synapse;Exposure to;Genetic;genetic approach;Hippocampus;Hyperactivity;Impaired cognition;improved;Individual;inhibitory neuron;insight;Interneurons;Long-Term Depression;Measures;Mediating;Modeling;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M1 Receptor;N-Methyl-D-Aspartate Receptors;Neurons;novel;novel therapeutic intervention;optogenetics;Parvalbumins;Patients;Peripheral;pharmacologic;Phospholipase C;Phospholipase D;Phospholipases A;Play;Population;positive allosteric modulator;postsynaptic;preclinical study;Prefrontal Cortex;Pyramidal Cells;receptor;Regulation;Rodent Model;Role;Schizophrenia;Series;Somatostatin;symptom cluster;symptomatic improvement;Symptoms;Synapses;synaptic inhibition;Testing;tool;transmission process;Whole-Cell Recordings

PROJECT_TITLE: Muscarinic Receptor Activators as Antipsychotic Agents

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


PHR: Project Narrative The overarching goal of the Yale Metabolic Phenotyping in Liver Models of Obesity and Diabetes Center (Yale MPMOD) is to provide extramural investigators access to the unique metabolic phenotyping services provided by the Yale MPMOD and empower them to harness the power of mouse genetics to its fullest potential to metabolically phenotype their mouse models of obesity and diabetes.

PI_NAMEs: SHULMAN, GERALD I (contact)

PROJECT_TERMS: Animals;Area;behavioral phenotyping;Biomedical Research;Client;Collaborations;Communities;Complex;complex data;cost;Data Analyses;data format;data standards;Data Storage and Retrieval;Diabetes Mellitus;digital object identifier;diversity and equity;empowerment;Experimental Designs;Extramural Activities;Funding;Goals;Guidelines;health equity promotion;Internships;Learning;Liver;Metabolic;Metabolic Diseases;metabolic phenotype;Metadata;Methodology;Methods;minority investigator;Modeling;Monitor;mouse genetics;mouse model;Mus;Obesity;operation;Phenotype;Physiological;programs;Protocols documentation;Quality Control;Reproducibility;Research;Research Personnel;Resources;screening;Services;Standardization;Technology;Testing;testing services;Training;Underrepresented Minority;web-based tool;Work

PROJECT_TITLE: Yale Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes


PROJECT_TERMS: Agreement;Catalogs;Client;Collection;Communication;cost effectiveness;data communication;Diabetes Mellitus;Ensure;innovation;Letters;material transfer agreement;metabolic phenotype;Modeling;Mus;Obesity;operation;Phenotype;programs;Records;Research Activity;Service provision;Services;Shipping;success;synergism;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because mobility is a key driver of the HIV/AIDS epidemic and mobile fishermen and their partners along Lake Victoria in Kenya are an exemplar mobile population who are at exceptionally high risk for HIV. Insights from this research will provide a comprehensive understanding of male engagement and relationship-level barriers and facilitators affecting safer conception uptake in the context of mobility and help high-risk HIV-affected couples to safely have children, affirm reproductive rights, and ultimately limit HIV transmission risks. This project is relevant to NIMH’s research priorities to advance the understanding of how human mobility affects engagement with HIV prevention and to develop prevention strategies to address these challenges for mobile populations who are at high risk of HIV transmission, acquisition, and care disengagement.

PI_NAMEs: GUTIN, SARAH A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Africa South of the Sahara;Age;AIDS prevention;Attention;Behavior;Behavior Therapy;Behavioral;care outcomes;career;Caring;Child;child bearing;Clinic;cohort;Collaborations;Communication;Complement;Conceptions;Counseling;Couples;Data;Dedications;design;Educational workshop;Epidemic;Evaluation;Face;Feedback;Female;Fertility;Fishes;flexibility;Gender;Geography;Goals;Health;Health Personnel;high risk;high risk sexual behavior;HIV;HIV Infections;HIV/AIDS;Household;Human;implementation intervention;improved;Incidence;Infant;Infrastructure;innovation;Insemination;insight;Internal Migrations;International Migrations;Interpersonal Relations;Intervention;intervention delivery;Interview;Kenya;Knowledge;Link;Location;male;Manuals;Marital Relationships;Measures;men;men's group;Mentorship;Methods;Motivation;National Institute of Mental Health;neglect;neonatal health;Outcome;Participant;Periodicals;pharmacologic;Population;pre-exposure prophylaxis;preference;pregnant;Prevalence;prevent;Prevention;prevention service;Prevention strategy;Preventive;preventive intervention;Protocols documentation;Provider;Psychology;Public Health;randomized trial;recruit;reproductive;Reproductive Health Services;Reproductive Rights;Research;Research Personnel;Research Priority;residence;Risk;Scientist;self testing;Services;sexual and reproductive health;sexually active;skills;social;social stigma;Stretching;Surveys;Techniques;Testing;theories;therapy design;Training;transactional sex;transmission process;uptake;Vagina;Vulnerable Populations;women's outcomes

PROJECT_TITLE: Couples Advancing Together for Safer Conception (CAT-SC): A couples’-based intervention to improve engagement in sexual and reproductive health services for mobile fisherfolk in Kenya

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

PI_NAMEs: MACY, JAMES D. (contact)

PROJECT_TERMS: Address;Age;animal care;animal resource;Animal Technicians;Animals;Biological;biosecurity;Client;cohort;Complement;Comprehensive Health Care;cost;Cross Infection;Dedications;Diabetes Mellitus;Diagnostic;electronic medical record system;Eligibility Determination;Ensure;Evaluation;Exogenous Factors;experience;Genetically Engineered Mouse;Genotype;Guidelines;health record;Health Status;Healthcare;high risk;House mice;Housing;imaging facilities;Institution;interest;Laboratories;Magnetic Resonance Imaging;metabolic phenotype;Microbiology;Modeling;Molecular Diagnostic Testing;molecular diagnostics;Mus;Obesity;Pathology;Phenotype;Procedures;Process;Protocols documentation;Quarantine;Reporting;Reproducibility;Research Personnel;Risk;risk stratification;Roentgen Rays;Serology;Services;Source;Testing;Therapeutic;trafficking;ultrasound;Veterinarians

PROJECT_TITLE: Animal Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative RNA-binding proteins (RBPs) and ribosomes are key molecules that drive and regulate post- transcriptional gene expression. RBPs are implicated in many different diseases including cancer and brain and neurodegenerative diseases (Fragile X syndrome, ALS). Ribosome-based genetic tools such as Ribo-TRIBE, Ribo-STAMP and Nanobody-editing will enable different areas of biology and medicine to address gene expression regulation within very small numbers of specific cells or neurons.

PI_NAMEs: ROSBASH, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Adult;Affinity Chromatography;Animals;Area;Biochemical;Biochemistry;Biocompatible Materials;Biological;Biological Assay;biological systems;Biology;Brain;Brain Diseases;cancer stem cell;Catalytic Domain;Cell Culture System;Cell Culture Techniques;Cell Line;cell type;Cells;Chimeric Proteins;circadian;Circadian gene expression;Circadian Rhythms;Communities;Complement;Computing Methodologies;Data;Development;Disease;Drosophila genus;Enzymes;experimental study;fly;Fractionation;Fragile X Syndrome;Future;Gene Expression;Gene Expression Regulation;Genetic;genetic regulatory protein;Genetic Transcription;Human;In Vitro;in vivo;knock-down;Knock-out;Labor Complications;Laboratory Study;Lateral;Malaria;Malignant Neoplasms;Mammalian Cell;Mammals;Medicine;Messenger RNA;Methods;mRNA sequencing;Mus;nanobodies;Neurodegenerative Disorders;Neurons;Neurosciences;Noise;novel strategies;Organism;overexpression;Pacemakers;Parasites;Persons;Pharmaceutical Preparations;Plants;Plasmids;Polyribosomes;Population;Post-Transcriptional Regulation;posttranscriptional;Protein Biosynthesis;Proteins;Recombinant Proteins;Recombinants;Regulation;Research Personnel;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA;RNA Editing;RNA-Binding Proteins;Role;Side;Signal Transduction;Site;Solid Neoplasm;Specificity;success;System;Testing;Therapeutic Intervention;Tissues;tool;Transcript;transcriptome sequencing;Transgenes;Transgenic Animals;Translating;translation assay;Translational Regulation;Translations;Tumor Stem Cells;Work

PROJECT_TITLE: Addressing Protein Synthesis Regulation within Small Numbers of Discrete Neurons

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: NARRATIVE The proposed project is aimed at determining the conditions under which feedback-based learning can be improved in children with developmental language disorder (DLD). Aim 1 will determine whether manipulating the timing of the feedback improves learning in children with DLD and aim 2 will compare learning under two feedback conditions, one that promotes active and intentional self-correction which is in line with declarative learning, and one that passively exposes the learner to corrective feedback and leads to learning that is assumed to be implicit in nature. For both aims, behavioral indicators of response to feedback will be complemented by electrophysiological measures of feedback processing that capture the involvement of implicit and declarative brain systems in the learning process.

PI_NAMEs: ARBEL, YAEL  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Affect;Behavioral;Brain;Child;Clinical;clinical practice;clinically significant;Data;design;Disease;Education;Educational process of instructing;effective intervention;Effectiveness;Electrophysiology (science);Evaluation;Exposure to;Feedback;follow-up;Goals;Impairment;improved;Intervention;Language;Language Development Disorders;Learning;Learning Disorders;learning outcome;Measures;Nature;novel;Paired-Associate Learning;parity;Process;programs;Quality of life;reinforced behavior;Research;response;School-Age Population;Self Correction;Shapes;success;System;Testing;theories;Time;Training;visual learning;Work

PROJECT_TITLE: Optimizing feedback-based learning in children with developmentallanguage disorder.

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Microbiome;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Currently, there are no FDA-approved drugs that can counteract GI acute radiation syndrome characterized by microbiome dysbiosis, destruction of mucosal layer, intestinal epithelial barrier dysfunction, and severe inflammation that can lead to rapid death. MIIST305 is a novel GI-targeted therapeutic that greatly enhances survival in mice exposed to lethal radiation and protects the GI tract from injury by maintaining a balanced gut microbiota and effectively reducing proinflammatory responses. Further development of this drug as an FDA- approved medical countermeasure will be of critical importance in the event of a radiation public health emergency.

PI_NAMEs: BROUSTAS, CONSTANTINOS G. (contact);TURNER, HELEN C

PROGRAM_OFFICER_NAME: RIOS, CARMEN I

PROJECT_TERMS: 16S ribosomal RNA sequencing;access restrictions;Accidents;Acute;Address;Affect;Animal Model;animal rule;Animals;Antibiotics;Architecture;Bacteria;bacterial community;Biological Assay;Bone Marrow;C57BL/6 Mouse;Cell Count;Cell Death;cell injury;Cells;Cessation of life;Colon;commensal microbes;cytokine;Development;Devices;Dose;drug development;dysbiosis;efficacy evaluation;Epithelial Cells;Epithelium;Event;Exposure to;FDA approved;fecal microbiota;Functional disorder;Funding;gastrointestinal;Gastrointestinal Injury;Gastrointestinal tract structure;Germ-Free;Gnotobiotic;Goals;gut inflammation;gut microbiota;Hematopoietic;Hematopoietic System;Hemorrhage;HMGB1 gene;Homeostasis;Hour;HT29 Cells;Human;Immune;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;Invaded;irradiation;Knockout Mice;Length;Lethal Dose 50;Ligands;Lipopolysaccharides;Macrophage;mass casualty;medical countermeasure;microbiome;microbiome composition;microbiota composition;Modeling;Molecular;Molecular Target;monocyte;Morphology;mouse model;Mucous body substance;Mucous Membrane;Multiple Organ Failure;Mus;novel;novel therapeutics;Nuclear;Oral Administration;pathogen;Pathway interactions;Pattern;Permeability;Pharmaceutical Preparations;preservation;Production;Public Health;public health emergency;Radiation;Radiation Accidents;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Protection;radiation response;Radiation Toxicity;Radiology Specialty;Resolution;response;Role;rRNA Genes;Sepsis;Severities;Signal Pathway;Structure;Surface;Syndrome;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Time;timeline;tissue regeneration;Tissues;TLR4 gene;Toll-like receptors;Toxic effect;Transgenic Mice;transplant model;treatment group

PROJECT_TITLE: Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome


PROJECT_TERMS: awake;Collaborations;Communities;cost;Databases;Development;Diabetes Mellitus;Diabetic mouse;empowerment;Extramural Activities;Functional disorder;genetic manipulation;in vivo;insight;Isotopes;Mass Fragmentography;Metabolic;metabolic phenotype;Metabolism;Methodology;Methods;Modeling;mouse model;Mus;novel;novel therapeutics;Obesity;Phenotype;phenotypic data;precision medicine;Price;Radiolabeled;Research Personnel;Services;stable isotope;Standardization;Tissues

PROJECT_TITLE: Phenotyping Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Mental Health;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Three in ten Americans have prediabetes – high blood sugar that could lead to type 2 diabetes. There are few effective ways to prevent prediabetes from developing into type 2 diabetes, but new research suggests that insomnia can increase people’s blood sugar, making type 2 diabetes more likely. In the proposed study, we will test whether therapy to treat insomnia can also lower blood sugar in people who have both insomnia and prediabetes, potentially preventing them from developing type 2 diabetes.

PI_NAMEs: LEBLANC, ERIN S (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: adipokines;Adult;Affect;American;Amputation;anxiety symptoms;arm;Behavioral;Blindness;Blood Glucose;Blood specimen;Body Weight decreased;Cardiovascular Diseases;Cell Physiology;Cessation of life;Chronic;Clinical;clinically significant;Cognitive Therapy;Continuous Glucose Monitor;Data;depressive symptoms;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diagnosis;Diet;digital;Eating;Educational Materials;Educational workshop;energy density;Equilibrium;evidence base;Exercise;fasting glucose;Feasibility Studies;food craving;Future;Glucose;glucose tolerance;Glycosylated hemoglobin A;Guidelines;Health;Health system;Healthy Eating;Heterogeneity;Hour;Hydrocortisone;Hyperglycemia;improved;improvement on sleep;indexing;Individual;Inflammation;Insulin Resistance;Intake;Intervention;intervention effect;Intervention Studies;Kidney Failure;Laboratory Study;Measures;Mediating;Metabolic;Modeling;moderate-to-vigorous physical activity;modifiable risk;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;Outcome;Pancreas;Participant;Pathway interactions;Patient Education;Patients;Persons;Physical activity;Physiological;Pilot Projects;poor sleep;Population;Population Study;Prediabetes syndrome;premature;Prevalence;prevent;primary outcome;programs;Quality of life;Randomized;randomized, clinical trials;recruit;Research;restoration;Rewards;Risk;Risk Factors;Sampling;secondary outcome;sedentary;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep onset;sleep quality;Sleeplessness;standard of care;stem;Testing;Time;tool;treatment arm;trend;United States;web site;Weight Gain;Work

PROJECT_TITLE: Sleep for Health: A randomized clinical trial examining the effects of cognitive behavioral therapy for insomnia on diabetes risk

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Vaccine Related

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE We propose novel, domain-independent, reusable methods for generalizing inferences from a cluster trial to a target population of substantive interest, by addressing bias due to selective trial participation. Specifically, we propose to develop and evaluate methods for (1) generalizing inferences about average treatment effects that account for dependence within clusters, small number of clusters, and small cluster sample sizes, and allow estimation using modern machine learning methods; (2) identifying the optimal covariate-dependent treatment strategy in the target population among a (possibly restricted) class of strategies; and (3) handling missing outcome data when generalizing inferences from cluster trials to the target population. Our proposal is motivated by 3 large-scale cluster trials of influenza vaccination strategies in U.S. nursing homes nested in nationally representative data.

PI_NAMEs: DAHABREH, ISSA J. (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Accounting;Address;Adjuvant;Affect;Clinical;cluster trial;Data;Data Collection;Data Science;deep learning;Dependence;design;Dose;Eligibility Determination;Enrollment;flexibility;follow-up;Funding;Healthcare Systems;Individual;Influenza vaccination;influenza virus vaccine;interest;Intervention;Investments;Knowledge;Machine Learning;machine learning method;Methodology;Methods;Modeling;Modernization;novel;novel strategies;Nursing Homes;optimal treatments;Outcome;Participant;Performance;Policies;Population;practice setting;random forest;Randomized;randomized trial;Randomized, Controlled Trials;Recombinants;Research;Research Design;Research Personnel;response;routine care;routine practice;Sample Size;simulation;Statistical Methods;Structure;support vector machine;Target Populations;tool;treatment effect;treatment strategy;Uncertainty;United States National Institutes of Health;vaccination strategy

PROJECT_TITLE: Methods for generalizing inferences from cluster randomized controlled trials to target populations

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Radiation Oncology

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: NARRATIVE MR-LINAC is the ideal platform for online adaptive radiotherapy and will bring cancer radiotherapy to a new level of precision and personalization. However, this new format of radiotherapy also comes with new challenges for patient safety and plan quality check that cannot be satisfactorily addressed with traditional quality assurance (QA) tools. This project is to address the urgent unmet clinical needs by developing the first intelligent, efficient, reliable, and independent QA system, to facilitate unleashing the full potential of MR- LINAC online adaptive radiotherapy to advance cancer care.

PI_NAMEs: JIANG, STEVE BIN (contact);NGUYEN, DAN ;ZHANG, YOU

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Anatomy;Artificial Intelligence;artificial intelligence model;Body Weight decreased;cancer care;cancer radiation therapy;Clinical;Clinical Research;Communication;Complex;Coupled;data acquisition;Development;Dose;Ensure;Evaluation;Expert Systems;Goals;Human;imaging capabilities;Institution;Intervention;Knowledge;learning algorithm;Linear Accelerator Radiotherapy Systems;Logistics;Magnetic Resonance Imaging;Measurement;Modeling;Modernization;Normal tissue morphology;Organ;Patient imaging;patient safety;patient variability;Patients;Physicians;preference;preservation;pressure;Procedures;Process;quality assurance;Radiation Dose Unit;radiation response;Radiation therapy;Risk;Safety;sample fixation;Schedule;soft tissue;System;Systems Development;Systems Integration;Testing;Therapeutic;Time;tool;Toxic effect;Training;transfer learning;Translations;treatment planning;tumor;Validation;Variant;Vendor

PROJECT_TITLE: Artificial Intelligence-Based Quality Assurance for Online Adaptive Radiotherapy

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Fundamental advances in our understanding of the normal function of the human brain, and how this understanding can be used to combat brain disorders, will increasingly depend on researchers equipped with multidisciplinary technical expertise. Major advances in the use of the light microscope to probe brain function have been made in the past three decades, and the technologies continue to improve and advance at a rapid rate. This grant supports an advanced hands-on summer course focused on using light microscopy approaches in the nervous system. The course communicates cutting- edge experimental approaches and concepts to a select cadre of postgraduate trainees, who will immediately apply what they learn to their own areas of neurobiological research. This highly intensive course provides a forum for in-depth evaluation of the emerging and converging light microscopy techniques to probe human brain function and disease, and helps to embed the trainees in a collaborative network of like-minded scientists who are working to understand brain function and the etiology of mental disorders.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Area;Biochemistry;Brain;Brain Diseases;Brain imaging;calcium indicator;Collaborations;combat;Communication;Communities;Computer software;Course Content;data acquisition;Data Analyses;Data Collection;design;Development;digital imaging;Disease;Educational process of instructing;Emerging Technologies;Enrollment;Ensure;Etiology;Evaluation;Exercise;experience;Experimental Designs;Faculty;Fluorescent Probes;forging;Functional disorder;Functional Imaging;Future;graduate student;Grant;Home;Human;Image;Image Analysis;image processing;imaging system;Imaging technology;improved;in vivo;instructor;interest;International;Knowledge;Laboratories;laboratory manuals;Lasers;Lead;Learning;lecturer;lectures;Light;Light Microscope;light microscopy;Mental disorders;Mental Health;Methodology;Methods;Microscopy;Mind;Molecular Biology;multi-photon;multidisciplinary;Nervous System;Neurobiology;online resource;Optics;optogenetics;Participant;Pharmacology;Physicians;Postdoctoral Fellow;Preparation;programs;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Role;Scanning;Scientist;Structure;Students;Synapses;System;Teaching Method;Technical Expertise;Techniques;Technology;tool;Training;Training Programs;Update;Work

PROJECT_TITLE: CSHL Imaging Structure & Function in the Nervous System


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Nutrition

PHR: Public Health Relevance Glaucoma is the leading age-related cause of irreversible blindness worldwide and will afflict an estimated 112 million people by 2040. The disease causes retinal and optic nerve degeneration through sensitivity to ocular pressure, but lowering pressure does not always stop progression. The work proposed here will test how adaptive mechanisms in the retina and optic nerve could slow degeneration and preserve vision in glaucoma by distributing energy resources where needed to enhance signaling from the retina to the brain.

PI_NAMEs: CALKINS, DAVID J. (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;Address;age related;Apoptotic;Astrocytes;Axon;axonal degeneration;axonopathy;BAX gene;Bioenergetics;Blindness;Brain;Cell Survival;cell type;Cellular Stress;Clinical;conditional knockout;Connexin 43;Connexins;Coupling;Data;Dendrites;Dependence;dietary;Dietary Supplementation;Disease;Electrophysiology (science);Exposure to;Glaucoma;Glycogen;Goals;Grant;improved;in vivo imaging;Individual;innovation;Insulin-Like Growth Factor I;Intervention;Knock-out;Light;Link;Maps;Measures;Metabolic;Metabolic stress;Metabolism;Microspheres;Modeling;Mouse Strains;Mus;National Eye Institute;Nature;Nerve;Nerve Degeneration;Neurons;neurotransmission;new therapeutic target;nonhuman primate;novel;Optic Disk;Optic Nerve;Optics;Outcome;Oxidative Stress;Patients;Pattern;Persons;Physiologic Intraocular Pressure;Physiological;preservation;pressure;prevent;Process;protective effect;public health relevance;Publishing;Pyruvate;repaired;Resources;response;restoration;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinotopic;Rodent;Saimiri;Signal Transduction;Sodium Channel;Stress;stress reduction;Supplementation;Testing;Therapeutic;therapeutic evaluation;tool;Transgenes;Transgenic Mice;Transgenic Organisms;Translating;Vision;voltage;Wallerian Degeneration;Work

PROJECT_TITLE: Mechanisms of Adaptive Remodeling and Their Therapeutic Potential in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


PHR: Project Narrative Focused ultrasound (FUS) neuromodulation will be combined with real-time MRI guidance and fMRI feedback to develop acoustic technologies (hardware, software, and activatable particles) for focal pharmacological neuromodulation of the monkey sensorimotor system. Safety will be monitored longitudinally and post-mortem. The proposed developments will improve the spatial capabilities of FUS neuromodulation, expand its use to focal pharmacological modulation, and provide key data to translate this technology to humans.

PI_NAMEs: CASKEY, CHARLES F (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Acoustics;Anesthetics;Automobile Driving;Autopsy;Behavioral;Blood - brain barrier anatomy;blood oxygen level dependent;blood-brain barrier permeabilization;Brain;BRAIN initiative;Brain region;Cells;Cephalic;Characteristics;Clinical Trials;Collaborations;Computer software;Contrast Media;cranium;Data;design;Development;Devices;Drug Delivery Systems;Elements;Excipients;Exposure to;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;Formulation;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Growth;Human;Image;image guided;improved;Inflammation;Laboratories;Liquid substance;Magnetic Resonance Imaging;Maps;Methods;Microbubbles;millimeter;millisecond;Modality;Molecular;Monitor;Monkeys;multidisciplinary;nanoemulsion;neuroimaging;Neurons;neuroregulation;next generation;nonhuman primate;open source;particle;patient population;Patients;Pentobarbital Sodium;Pharmaceutical Preparations;pharmacologic;Phase;Physical condensation;Physiologic pulse;pressure;Procedures;Publishing;putamen;Rattus;Research;Research Personnel;response;Risk;Rodent;Safety;safety assessment;Scheme;sensorimotor system;side effect;software development;somatosensory;Spottings;System;Technology;Time;tool;Transducers;Translating;translational model;Translations;treatment planning;Ultrasonic Transducer;ultrasound;Work

PROJECT_TITLE: Next generation transcranial ultrasound-based neuromodulation using phase shift nanoemulsions


ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Methylation of cytosine in CpG dinucleotides plays a critical role in gene organismal development, and its deregulation is commonly observed in cancer. This application will focus on the epigenetic mechanisms of regulation of the de novo DNA methyltransferase DNMT3A by post-translational modifications of histones. These novel insights will provide an enhanced understanding of DNMT3A, reveal the role of histone modifications in regulating its recruitment, activity, and function, and lay the foundation for developing novel inhibitors that could be used for cancer therapeutics.

PI_NAMEs: ARMACHE, KARIM JEAN (contact);LU, CHAO

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Ablation;Binding;Biochemistry;Cancer Biology;cancer cell;cancer initiation;Cell Differentiation process;Cells;Cellular Assay;Chromatin;chromatin modification;Complex;CpG dinucleotide;CpG Islands;Cryoelectron Microscopy;Cytosine;design;Development;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3a mutation;DNMT3B gene;Enzymes;Epigenetic Process;epigenomics;Equilibrium;Family;FDA approved;Foundations;Frequencies;Gene Expression Regulation;Genes;Genetic;genome-wide;Genomics;histone modification;Histones;Human;human disease;Hypermethylation;Impairment;Individual;inhibitor;insight;Intercistronic Region;interdisciplinary approach;Length;Malignant Neoplasms;Mediating;member;Meta-Analysis;Methylation;Methyltransferase;Missense Mutation;Modeling;Molecular;Molecular Conformation;Monoubiquitination;Mus;Mutate;Mutation;N-terminal;Neoplastic Cell Transformation;Normal tissue morphology;novel;Nucleosomes;Oncogenic;Organoids;Patients;Pattern;Play;Polycomb;Post-Translational Protein Processing;PRC1 Protein;promoter;Protein Isoforms;Publishing;recruit;Recurrence;Regulation;RNA Splicing;Role;Sampling;Site;stem cells;Structure;Testing;Therapeutic;Therapeutic Index;Tissue Differentiation;Tissues;Toxic effect;tumor;Tumor Suppressor Genes;tumorigenesis;Variant;Work

PROJECT_TITLE: Molecular basis for aberrant de novo DNA methylation in cancer

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Clear cell renal cell carcinoma (ccRCC) is currently the 8th leading cause of cancer death in the United States and is unusual for its high frequency of epigenome regulator gene mutations, including a gene called SETD2 that when mutated, is associated with reduced survival and metastasis. Identification of genes that act as redundant backups to known cancer mutations is a proven approach to identifying new therapeutic drug targets. Using this approach, called “synthetic lethality” we identified novel and druggable pathways that we expect to lead to a better understanding of how SETD2 loss drives ccRCC and new ways to therapeutically target tumors with this mutation.

PI_NAMEs: HO, THAI HUU;ROBERTSON, KEITH D (contact)

PROJECT_TERMS: actionable mutation;Affect;Automobile Driving;bevacizumab;Biological;Biological Assay;Cancer Etiology;cell growth;Cell Line;Cell Survival;Cells;Cessation of life;ChIP-seq;Chromatin;Clear cell renal cell carcinoma;Clinical Treatment;clinically actionable;combinatorial;Compensation;CRISPR interference;CRISPR screen;Defect;Disease;DNA;DNA Methylation;Drug Targeting;efficacy validation;Enhancers;Epigenetic Process;epigenome;Exhibits;Family;FDA approved;Frequencies;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Epistasis;genome-wide;Genotype;Health;Histone H3;Histones;Homeostasis;Human;Immune checkpoint inhibitor;in vivo;Individual;individualized medicine;inhibitor;Injections;Link;loss of function;loss of function mutation;Lysine;Malignant Epithelial Cell;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methylation;Modeling;molecular phenotype;mouse model;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;Organoids;Outcome;Pathway interactions;Patients;personalized therapeutic;pharmacologic;Phenocopy;Phenotype;pre-clinical;Primary Neoplasm;Proteins;Regulator Genes;Renal Carcinoma;Renal Cell Carcinoma;Repression;response;RNA;Role;Scheme;side effect;Signal Pathway;Signal Transduction;small molecule inhibitor;Solid Neoplasm;Specificity;standard of care;Tail;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;TP53 gene;transcriptome;tumor;tumor growth;Tumor Tissue;Tumorigenicity;United States;Veins;virtual;Writing

PROJECT_TITLE: Synthetic Lethal Targeting of SETD2 in Renal Cell Carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(02)M]


NIH_SPENDING_CATS: Cancer

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE  A significant workforce shortage is looming for cancer-focused careers, underscoring a critical need to recruit and train the next generation of providers and researchers. To inspire and prepare undergraduates to pursue careers in cancer research and/or healthcare delivery, a Fox Chase Cancer Center (FCCC)-University of Delaware (UD) intensive, summer internship program is proposed. Key elements of this program include a one- week preparatory course, taught at UD, focused on lab skills, research ethics, and basic information about cancer biology, followed by a 10-week residential program at Fox Chase which integrates a laboratory internship with professional skill development.

PI_NAMEs: GOLEMIS, ERICA A. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;aging population;anti-cancer research;Arts;Cancer Biology;cancer care;career;Career Choice;career development;career networking;Clinical;college;Communication;Communities;Comprehensive Cancer Center;Critical Thinking;Decision Making;Delaware;design;Development;Education;Educational process of instructing;Elements;empowerment;Ensure;Evaluation;Event;experience;Exposure to;faculty mentor;Feedback;Fellowship Program;Foundations;Fox Chase Cancer Center;Goals;graduate student;health care delivery;Health Personnel;Healthcare Market;High School Student;Human Resources;Incentives;interest;Internships;Laboratories;Laboratory Research;Learning;Learning Skill;Malignant Neoplasms;medical schools;meetings;Mentors;next generation;novel;Oral;peer;Physicians;posters;programs;Provider;Recording of previous events;recruit;Research;research and development;Research Ethics;Research Personnel;Resources;Rotation;Science;scientific literacy;Scientist;skill acquisition;skills;social;statistics;Students;success;summer internship;summer research;symposium;Techniques;Time;tool;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;United States;Universities;Visit;Work;Writing

PROJECT_TITLE: Empowering the Next Generation of Cancer Professionals: the Fox Chase Cancer Center-University of Delaware Partnership for Undergraduate Research and Career Development

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: NEW ORLEANS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Overall Project Narrative The Program Project will determine if and how estrogens interact with cardiovascular and metabolic health to impact the brain and cognitive aging. Understanding conditions under which administration of estrogens are beneficial or harmful is critical to developing a personalized approach in recommendations for use of menopausal hormone therapy in women.

PI_NAMEs: DANIEL, JILL M (contact)

PROJECT_TERMS: Affect;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavior;blood glucose regulation;Blood Vessels;Brain;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Clinical Data;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;cognitive function;Cyclophosphamide;design;Development;Diet;Disease;Ensure;ESR1 gene;Estradiol;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Female;Functional disorder;Goals;Health;Health Status;High Fat Diet;Hippocampus;Homeostasis;hormone therapy;Hormones;Hypertension;Impaired cognition;Impairment;Incidence;Insulin Resistance;Investigation;Leadership;Long-Term Potentiation;Measurement;Memory;menopausal hormone therapy;Menopause;Metabolic;Metabolic syndrome;middle age;midlife estradiol;Modeling;Molecular;multicatalytic endopeptidase complex;Nerve Degeneration;neuroprotection;neurovascular coupling;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;Ovarian;personalized approach;Physiological;Pre-Clinical Model;preservation;Procedures;Process;Program Research Project Grants;programs;Recommendation;Regulation;Reproducibility of Results;Research;response;Risk Factors;Rodent Model;Signal Pathway;Synaptic plasticity;System;Testing;Ubiquitin;Variant;Vascular Dementia;Weight Gain;Woman

PROJECT_TITLE: Estrogens, Cardiometabolic Health, and Female Cognitive Aging


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Sexually Transmitted Infections

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative: Alzheimer’s Disease is a devastating neurodegenerative disease, the most common cause of dementia, and a significant healthcare burden worldwide, with many complex genetic and environmental drivers that remain uncharacterized. Pathogenic infections have been proposed as a potential risk factor for Alzheimer's, by triggering an immune response utilizing Amyloid beta as antimicrobial peptides, which protect against infections in the short term, but ultimately cause excessive Aβ deposition and the pathological cascades that ultimately lead to dementia, a link particularly relevant given the Covid-19 pandemic. Here, we dissect the potential mechanistic basis of such pathogen-Alzheimer's interactions using cutting-edge experimental and computational methods, and focusing on HSV-1 and CMV infections as a model for Alzheimer's-pathogen interactions in hopes for this to provide a foundation for both a deeper understanding of how pathogens impact Alzheimer's and the development of new therapeutics against this devastating disorder.

PI_NAMEs: KELLIS, MANOLIS  (contact);TANZI, RUDOLPH EMILE

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 3-Dimensional;abeta deposition;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;anti-microbial peptide;Atlases;Autopsy;base;Biological Assay;Blood Vessels;Brain;brain cell;Brain region;causal variant;Cell Communication;Cell Survival;cell type;Cells;Central Nervous System;cerebrovascular;Coculture Techniques;Complex;Computing Methodologies;COVID-19 pandemic;CRISPR interference;Cytomegalovirus;Cytomegalovirus Infections;Data;data integration;Data Set;Dementia;Development;Disease;Disease Progression;Dissection;Environmental Impact;Etiology;Family;Foundations;frontal lobe;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Goals;healthcare burden;Herpesvirus 1;Hippocampus;Human;human induced pluripotent stem cells;Immune;Immune response;Impaired cognition;Individual;induced pluripotent stem cell;Infection;Intervention;Joints;Life;Link;Maps;Mediating;Memory Loss;Messenger RNA;Microglia;Modeling;Molecular;Molecular Mechanisms of Action;Mus;Neurodegenerative Disorders;neuroinflammation;Neurons;novel therapeutics;Organoids;pathogen;Pathogenicity;Pathologic;Pathway interactions;personalized medicine;personalized therapeutic;Phenotype;Post-Translational Protein Processing;protein expression;Regulatory Element;Research;Resolution;Resources;risk variant;Role;Sampling;Severities;sex;Simplexvirus;single nucleus RNA-sequencing;single-cell RNA sequencing;small molecule therapeutics;Testing;Transcription Alteration;Validation;Virus

PROJECT_TITLE: Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV


NIH_SPENDING_CATS: Aging;Estrogen;Women's Health Research

PROJECT_TERMS: Advisory Committees;Affect;Aging;Agreement;Annual Reports;Area;Biometry;Brain;cardiometabolism;Cognitive;Cognitive aging;Collection;Communication;Data;data dictionary;data management;Data Security;data sharing;Data Storage and Retrieval;Development;Disease;Ensure;Estradiol;Estrogen Therapy;Estrogens;Experimental Designs;Faculty;Feedback;Female;Funding;Goals;Health;Impaired cognition;improved;Information Dissemination;Investigation;Joints;Lead;Leadership;Logistics;Manuscripts;Measures;meetings;Menopause;Methods;Monitor;Occupational activity of managing finances;Office of Administrative Management;Participant;Policies;Procedures;Program Evaluation;programs;quality assurance;Quality Control;Recommendation;Reporting;Research;Research Design;Research Project Grants;Research Support;Schedule;Scientist;Series;Specific qualifier value;Statistical Data Interpretation;success;symposium;Testing;United States National Institutes of Health;Vision

PROJECT_TITLE: Administrative Core


PI_NAMEs: LINDSEY, SARAH H. (contact)

PROJECT_TERMS: Animal Feed;Animals;Area;Biological Markers;Blood Pressure;Body Composition;Body Weight;Calendar;Cardiac;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cognitive aging;Communities;Data;Data Collection;Dedications;Diet;Disease;disease model;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Equipment;Estrogens;experience;Experimental Designs;Extramural Activities;feeding;Female;Glucagon;Glucose tolerance test;Goals;Health;High Fat Diet;Housing;Human Resources;improved;in vivo;Insulin;Insulin Resistance;Maintenance;Measurement;medical schools;meetings;Metabolic;Metabolic Diseases;Metabolic hormone;Monitor;Mus;Phytoestrogens;Procedures;programs;Protocols documentation;Radioimmunoassay;Rattus;Renin-Angiotensin System;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Reservations;Resources;sample collection;Sampling;Schedule;Schools;Science;Services;Standardization;standardize measure;synergism;System;Tissue Banks;Tissues;ultrasound;web site

PROJECT_TITLE: Cardiometabolic Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Squamous cell carcinoma is a major cause of mortality, but despite breakthroughs in genetics, little is known about the role of post-translational modifications, including the most abundant PTM protein glycosylation. In this proposal, I will use murine skin as a highly tractable model system to investigate SCC glycosylation. By discovering how carbohydrates change in SCC and the downstream consequences, my work has the potential to dramatically improve our understanding of SCC and identify new therapeutic opportunities.

PI_NAMEs: KUDELKA, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 3-Dimensional;Address;Animals;Antibodies;ATAC-seq;Binding Proteins;Biological Models;Biology;cancer genetics;Carbohydrates;career;Cause of Death;Cells;chemotherapy;clinical translation;Complementary DNA;CRISPR screen;Data;Development;Disease;drug candidate;Environment;Epidermis;first-in-human;Foundations;functional genomics;Genetic;Genetic Models;Genome;Glycobiology;Glycoproteins;glycoproteomics;Glycoside Hydrolases;glycosylation;Grant;Heterogeneity;high-throughput drug screening;Histologic;Human Cell Line;Image;improved;in utero;in vivo;Incidence;Individual;Injections;insight;keratinocyte;Knowledge;Label;Leadership;Learning;Lentivirus;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Medical Oncologist;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Mentorship;Metabolic;Methods;Microscopy;Modeling;Modification;Monosaccharides;mortality;mouse model;multimodality;Mus;mutant;nanobodies;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Oncoproteins;Papilloma;Pathway interactions;Phase;Physicians;Polysaccharides;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Postdoctoral Fellow;Protein Glycosylation;Proteins;Recurrence;Regulation;Research;Research Personnel;Role;Scientist;Signal Transduction;Site;Skin;Skin Cancer;skin squamous cell carcinoma;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Squamous cell carcinoma;Structure;Techniques;Technology;Testing;therapeutic candidate;Time;Tissues;Training;transcriptome sequencing;transcriptomics;tumor;Tumor Biology;Tumor Suppressor Proteins;tumorigenesis;Universities;Visualization;Work

PROJECT_TITLE: Functional Landscape of Glycosylation in Skin Cancer


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Estrogen;Menopause;Neurosciences;Women's Health Research

PI_NAMEs: SCHRADER, LAURA  (contact)

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Animal Model;Animals;Area;arm;Behavior;Behavior assessment;behavior test;Behavioral;biological age;Brain;cardiometabolism;Cardiovascular Diseases;Clinic;Cognition;Cognitive;Cognitive aging;cognitive function;Collaborations;Communities;Data;Data Analyses;Data Collection;Dedications;Dietary Component;discrimination task;Disease;disease model;Engineering;Ensure;Equipment;Estradiol;Estrogen Therapy;Estrogens;Evaluation;Experimental Designs;Female;Goals;Grant;Health;Hippocampus;hormone therapy;Hormones;Human Resources;in vivo;Individual;Institution;Investigation;Lead;Measurement;Measures;medical schools;Memory;Menopause;Methods;middle age;Modeling;novel;Obesity;Operative Surgical Procedures;Ovariectomy;parenting intervention;Pathologic;pathological aging;Performance;Prefrontal Cortex;Procedures;programs;Protocols documentation;Radial;Reproducibility;Reproductive History;Research;Research Design;Research Personnel;Research Project Grants;Rodent;Rodent Model;Schools;Science;sensory discrimination;Services;spatial memory;Standardization;subcutaneous;success;Testing;timeline;web site;Work

PROJECT_TITLE: Hormones & Behavior Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE  To address reproducibility and power issues in aging and Alzheimer’s disease research, we launch ENIGMA’s World Aging Center, a global brain study of aging and AD across 45 countries. Leveraging our ENIGMA network (340 institutions), we launch 4 coordinated projects to empower genetic and epigenetic studies of brain aging: (1) Enigma-Lifespan- creates normative charts of brain aging metrics from MRI, diffusion imaging, and functional MRI in 20,000 people worldwide; (2) ENIGMA-Epigenetics- relates genome-wide methylation to brain aging; (3) ENIGMA-Plasticity- seeking genetic loci affecting brain atrophy rates; and (4) ENIGMA-Alzheimer’s- to identify how Alzheimer’s genetic risk and new risk scores for accelerated tissue loss, affect the brain. We will analyze worldwide imaging, epigenetic, and clinical data with harmonized methods, to create new aging “clocks” and reveal targetable risk factors and modifiers of brain aging in the genome and blood, worldwide.

PI_NAMEs: THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;Age-associated memory impairment;aged;Aging;aging biomarker;aging brain;aging clocks;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;Atrophic;Biological;biological age;Blood;Brain;brain tissue;brain tract;Capital;cerebral atrophy;Chronology;Clinical;Clinical Data;clinical predictors;cognitive performance;cohort;cost;Cost of Illness;Country;Cytosine;Data;Data Collection;Data Set;Dementia;Diffusion;Diffusion Magnetic Resonance Imaging;disorder risk;DNA;economic cost;Educational Status;empowerment;Epigenetic age;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;epigenome-wide association studies;epigenomics;executive function;fluorodeoxyglucose positron emission tomography;functional decline;Functional Magnetic Resonance Imaging;Funding;Genetic;Genetic Carriers;Genetic Risk;Genetic study;Genome;Genome Mappings;genome wide methylation;genome-wide;genomic locus;Genomics;global health;Goals;Grant;Guanine;Haplotypes;hazard;Health Priorities;Hippocampus;human old age (65+);Image;imaging genetics;indexing;Infrastructure;inorganic phosphate;Institution;International;Libraries;Life;life span;longitudinal analysis;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;men;Mental disorders;Methods;mortality;multimodality;Nature;Nerve Degeneration;Nervous System Disorder;neural tract;neuroimaging;neuroimaging marker;Nomograms;novel;pathological aging;Pattern;Persons;physical conditioning;Pilot Projects;polygenic risk score;Population;Population Heterogeneity;Predisposition;processing speed;Productivity;prototype;Proxy;Publications;Publishing;Pythons;Qualifying;Reproducibility;Research;Rest;Risk;Risk Factors;Role;Science;sex;Site;Structure;Testing;Tissues;Variant;Woman;Work

PROJECT_TITLE: ENIGMA World Aging Center

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Estrogen;Hypertension;Menopause;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Women's Health Research

PROJECT_TERMS: Affect;Age;age effect;age related;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Angiotensin II;Animals;Area;Basic Science;blood glucose regulation;Body fat;Body measure procedure;Brain;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Clinical Data;Clinical Research;Cognition;Cognitive;Cognitive aging;cognitive skill;Cognitive Therapy;Data;dietary control;Disease;ESR1 gene;Estradiol;Estrogen Therapy;Estrogens;expectation;experimental study;Fatty acid glycerol esters;Female;Functional disorder;Goals;Health;Health Status;healthy aging;High Fat Diet;Hippocampus;hormone therapy;human old age (65+);Hypertension;hypertensive;Impairment;Individual Differences;Longitudinal Studies;Maintenance;Measures;Mediating;Memory;Memory Disorders;menopausal hormone therapy;middle age;midlife estradiol;Midlife women;Modeling;multicatalytic endopeptidase complex;neuroprotection;Obesity;Ovarian;Ovariectomy;pre-clinical research;Prevention;protective effect;Rattus;receptor;Regulation;Research;Research Design;response;Risk;Rodent Model;Role;System;Testing;Time;Ubiquitin;Weight Gain;Woman

PROJECT_TITLE: Impact of hypertension and high-fat diet on mechanisms by which estradiol affects the hippocampal memory system.