NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Accountability;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral;Cognitive;Collaborations;Collection;Communication;Communities;data collection site;Data Storage and Retrieval;Development;digital;Discipline;Documentation;Ensure;Evaluation;experience;Financial Support;Funding;Intellectual Property;interest;Libraries;Measures;meetings;Modification;Monitor;Online Systems;Outcome Measure;Periodicals;Persons;Policies;programs;Publications;Recommendation;Reporting;Research;Research Personnel;Resolution;Resources;Schedule;Scientist;Self Assessment;Structure;System;Teleconferences;Testing;United States National Institutes of Health;usability;Work;working group

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Cancer;Clinical Research;Rheumatoid Arthritis

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE As the world population is aging, living with more than one chronic condition (multimorbidity) is the norm rather than the exception and yet, older adults are often excluded from clinical trials based on multimorbidity or their age alone. Here we propose studies to understand the contributions of rheumatoid arthritis (RA), a chronic, inflammatory disease on survival, development of geriatric syndromes such as frailty, body composition, and quality of life in older adults with cancer. The goal of this research is to risk stratify older adults with RA and cancer at highest risk of mortality and development of geriatric syndromes and ultimately develop tailored approaches (based on this risk stratification) to improve their quality of life and potentially survival.

PI_NAMEs: SINGH, NAMRATA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Adult;Age;Aging;Area;Award;Biological Products;Body Composition;Body measure procedure;cancer diagnosis;cancer survival;cancer type;career;career development;Characteristics;Chronic;Chronic Disease;Clinical;clinical care;clinical practice;Clinical Trials;cohort;Cohort Studies;comorbidity;Complex;Cox Proportional Hazards Models;Cross-Sectional Studies;Data;Databases;demographics;Development;Diagnosis;Disease;Elderly;evidence base;Exclusion;Fatigue;Fatty acid glycerol esters;frailty;Funding;Future;General Population;Geriatrics;Goals;high risk;Hospitalization;improved;improved outcome;indexing;Individual;Infection;Inflammatory;Intervention;Investigation;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Mentors;Mentorship;Methods;mortality;mortality risk;multiple chronic conditions;novel therapeutics;older adult;Oncology;Outcome;Patients;personalized approach;Phenotype;Physicians;Population;Positioning Attribute;Prospective cohort;Quality of life;Reporting;Research;research and development;Research Personnel;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Risk;Risk Factors;Risk Marker;risk stratification;sarcopenia;sarcopenic obesity;Scientist;sex;skills;Stage at Diagnosis;Syndrome;Thinness;Training;United States Department of Veterans Affairs

PROJECT_TITLE: Impact of rheumatoid arthritis on survival in older adults with cancer


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PI_NAMEs: KAAT, AARON JAMES (contact)

PROJECT_TERMS: Adherence;Alzheimer's Disease;Alzheimer's disease related dementia;Automatic Data Processing;Award;Behavioral;Big Data;cardiovascular health;Cellular Phone;Clinical;Clinical Data;cloud based;Code;Cognitive;cognitive ability;cognitive change;community engaged approach;Computing Methodologies;Consultations;Data;Data Aggregation;Data Analyses;data analysis pipeline;Data Analytics;data cleaning;Data Collection;data management;data pipeline;data platform;Data Provenance;data repository;data reuse;Data Scientist;Data Set;data sharing;data standards;Data Storage and Retrieval;Decentralization;density;design;Development;direct application;Ensure;experience;Future;Goals;high standard;informant;Information Systems;Infrastructure;innovation;interest;International;Learning;Length;Libraries;Life Cycle Stages;Location;longitudinal analysis;Longitudinal Studies;Longitudinal, observational study;Machine Learning;Measurement;Measures;Meta-Analysis;Metadata;Methodology;mHealth;Monitor;Movement;multidisciplinary;Multiple Sclerosis;Noise;novel;Outcome Measure;Parkinson Disease;Participant;Patient Outcomes Assessments;Patient Self-Report;Pattern;Performance;platform as a service;Population;Process;Psoriasis;Psychometrics;Quality Control;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;response;Sampling;Science;Scoring Method;Services;sleep quality;social;software as a service;Specific qualifier value;Statistical Data Interpretation;Structure;supervised learning;support tools;Surveys;Synapses;System;tool;United States National Institutes of Health;Validation;validation studies;Validity and Reliability;Work

PROJECT_TITLE: Data  Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: KELLEN, MICHAEL ROBERT (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Android;Area;Assessment tool;Behavioral;Cellular Phone;Cognitive;Communication;Computer software;contextual factors;Custom;Data;data harmonization;Data Security;data streams;design;Development;Ensure;Exhibits;Feedback;Funding;Future;Goals;Grant;handheld mobile device;improved;Infrastructure;Internet;Libraries;life span;Maintenance;Measures;middle age;Monitor;open source;Operating System;Participant;Pathologic;Pathologic Processes;Patient Recruitments;Performance;Physiological;preference;Privacy;Protocols documentation;psychologic;recruit;remote administration;remote assessment;Research;Research Design;Research Methodology;Research Personnel;response;Risk;Running;Secure;Security;Self Administration;sensor;Services;study population;Surveys;System;Systems Development;Technology;technology development;Testing;Time;tool;usability;virtual

PROJECT_TITLE: Technical Core


PI_NAMEs: NOWINSKI, CINDY J. (contact)

PROJECT_TERMS: Acceleration;Adoption;application programming interface;Awareness;Behavioral;Clinical Data;Code;Cognitive;cognitive change;cognitive function;cognitive testing;Communities;Consent;Consultations;Consumer Organizations;cost;Custom;Data;Data Collection;data de-identification;data repository;data sharing;Development;distributed data;Documentation;Ensure;Evaluation;Evolution;Exhibits;Funding;Funding Agency;Government;Grant;Growth;Guidelines;improved;Infrastructure;Learning;Libraries;Licensing;Manuscripts;Measures;Modality;Modeling;Monitor;Nonprofit Organizations;outreach;Professional Meetings and Conferences;Professional Organizations;psychologic;Recovery;Research;Research Activity;Research Design;Research Personnel;Research Support;Resources;response;Secure;Services;social media;Students;sustainability framework;System;Technology;Testing;Training;United States National Institutes of Health;Update;web site

PROJECT_TITLE: Extension and Dissemination Core


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Given the insufficiency of current interventions to reduce or prevent the lifelong morbidity and mortality associated with neonatal herpes simplex virus (nHSV) infection, there is a critical need to develop new therapies. A promising strategy is to use monoclonal antibodies to recapitulate the protection associated with maternal antibodies whose placental transfer is capable of both virus neutralization and eliciting effector functions of the innate immune system. The development of effective vaccines and therapeutic antibodies for nHSV infections will benefit from a fuller understanding of antibody mechanism(s) of action that can prevent this devastating disease.

PI_NAMEs: ACKERMAN, MARGARET E (contact);LEIB, DAVID A

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Active Biological Transport;Acyclovir;Adult;Affinity;aggressive therapy;Antibodies;antibody engineering;Antibody Therapy;antibody transfer;Antibody-mediated protection;Automobile Driving;Behavioral;Binding;Biological Models;Birth;Central Nervous System;Cessation of life;Clinical;clinical investigation;Communicable Diseases;Complex;Congenital herpes simplex;Coupled;Data;design;Development;Disease;Economic Burden;Encephalitis;Epidemiology;Evaluation;Fc domain;Fc Receptor;fetal;Fetal health;fetal infection;Fetal Tissues;Fetus;Glycoproteins;Goals;Herpes Simplex Infections;Herpes Simplex Virus Vaccines;Herpesviridae;Herpesvirus 1;Human;Human Herpesvirus 2;Humoral Immunities;Immune Evasion;Immunization;Immunoglobulin G;improved;In Vitro;in vivo;Infant;Infection;infection risk;Inherited;inhibiting antibody;innate immune function;Innate Immune System;innovation;insight;Intervention;Knowledge;Life;life span;Maternal antibody;maternal immune system;Modeling;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;Mothers;mouse model;Neonatal;neonatal health;Neonatal Mortality;neonatal period;neonate;neural;Neurologic;Newborn Infant;next generation;novel;novel therapeutics;novel vaccines;Outcome;pathogen;Pathology;Placenta;placental transfer;Play;Population;postnatal period;preclinical study;Pregnant Women;prevent;Prevention;prophylactic;receptor function;Regimen;Reporting;Risk;Role;seropositive;Simplexvirus;Testing;Therapeutic;Therapeutic antibodies;Vaccine Design;vaccine development;vaccine-induced antibodies;Viral;Viral Load result;Virus;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: Understanding and optimizing antibody-based interventions against neonatal HSV infection

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative

PI_NAMEs: WEINTRAUB, SANDRA  (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;Alzheimer's disease related dementia;Android;Assessment tool;Attention;Behavior;Behavioral;biological sex;Biosensor;Calibration;Cellular Phone;Clinic;Clinical;Cognitive;cognitive change;cognitive function;cognitive task;Collection;Computer software;Computers;contextual factors;Data;Data Analyses;Data Collection;data management;Decision Making;Dementia;design;Education;Emotional;Ethnic Origin;Etiology;evidence base;experience;flexibility;follow-up;Future;Gait speed;General Population;Geography;Goals;Gold;Health;health disparity;Hearing;Heart Rate;Impaired cognition;improved;incentive strategies;Incentives;Individual;Informal Social Control;Intervention;Libraries;life span;Link;Location;Longitudinal Studies;Measurement;Measures;Medicine;Methods;minority health;mobile application;mobile computing;Monitor;Motivation;Participant;participant retention;patient engagement;Patient Self-Report;Performance;person centered;Personality;Physical Function;Physiological;Population;Procedures;Process;Property;Protocols documentation;Proxy;psychologic;Psychometrics;Race;recruit;remote assessment;Reporting;Research Design;Research Personnel;Respondent;response;retention rate;Sampling;Schedule;Self Administration;sensor technology;Series;skills;social;Specific qualifier value;Specificity;Stress;stress reactivity;study population;Testing;theories;United States National Institutes of Health;Update;Validation;validation studies;Work

PROJECT_TITLE: Project Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Substance use disorder (SUD) and HIV are synergistic epidemics (syndemics) disproportionately affecting Black Americans, but SUD among Black people living with HIV is often undiagnosed and untreated. Therefore, we will implement and evaluate multi-level interventions including electronic patient portals for SUD screening and the Collaborative Care Model for SUD treatment to decrease structural barriers to SUD care. Our goal is to achieve health equity in SUD screening and treatment among Black people living with HIV.

PI_NAMEs: LAITEERAPONG, NEDA ;RIDGWAY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Affect;AIDS prevention;barrier to care;behavioral health;Black American;Black Populations;Black race;care systems;Caring;Case Manager;Cellular Phone;Chicago;Clinic;Clinic Visits;collaborative care;Communities;community advisory board;Community Health Aides;density;Depression screen;design;Diagnosis;digital health;Disparity;Education;Effectiveness;effectiveness evaluation;Electronics;Enrollment;Ensure;Epidemic;Equity;Face;Funding;Gender;Goals;Health;health care availability;health equity;Health Technology;HIV;HIV diagnosis;Home;Housing;improved;Incidence;Income;Insurance;interest;Intervention;Interview;Learning;Life;Managed Care;Mediating;Medicine;Minority Groups;Modeling;mortality;Neighborhoods;Newly Diagnosed;Outcome;patient engagement;Patient Outcomes Assessments;patient portal;patient-clinician communication;Patients;Persons;population health;Prevalence;prevention service;Privacy;programs;Provider;Psychiatrist;Psychiatry;Public Health;Race;Randomized, Controlled Trials;response;routine screening;screening;Secure;Sexual and Gender Minorities;Side;Site;social health determinants;social stigma;Social Work;Structural Racism;substance use;Substance Use Disorder;syndemic;Telephone;Text Messaging;Time;Training;treatment center;Universities;user centered design;Viral;Visit;web site;Work

PROJECT_TITLE: Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life with HIV and Substance Use (ePORTAL HIV-S)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Relevance to Public Health The identification, recruitment, selection, and mentorship of scientists from diverse backgrounds to conduct research on Alzheimer’s Disease and Related Dementias (ADRD) (i.e., AD-RCMAR Scientists) and to launch their independent research careers will enhance the diversity of the aging research workforce. The work of the AD-RCMR Scientists and the San Diego Alzheimer’s Disease Resource Center for Minority Aging Research will promote critical advances in our understanding and ability to target multilevel factors and interventions to address ADRD inequities among Hispanics/Latinos, limited English proficient (LEP) and refugee communities.

PI_NAMEs: ELDER, JOHN P.;GILBERT, PAUL E;MOORE, ALISON AHERN (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;behavioral and social science;Biological;brain health;California;career;career development;Career Mobility;Climate;Clinical;Cognitive aging;Collaborations;Collection;Communication;Communities;community collaboration;community engaged research;community partners;County;Data;Data Analyses;Discipline;Disparity;Education;education research;Elderly;Engineering;equity, diversity, and inclusion;experience;Faculty;Fostering;Geriatrics;Gerontology;Health Disparities Research;health inequalities;Hispanic;Hispanic Populations;Hispanic-serving Institution;Home;Individual;Inequity;Infrastructure;Institution;Interdisciplinary Study;Intervention;Investigation;Knowledge;Latino;Latino Population;Leadership;Life Cycle Stages;Limited English Proficiency;Linguistics;Measurement;Measures;Medicine;member;Mentors;Mentorship;Mexico;Minority;Minority Groups;Minority Health Research;novel;older adult;Palliative Care;Pharmacologic Substance;Population;Population Heterogeneity;Positioning Attribute;Principal Investigator;programs;Psychology;Psychometrics;Public Health;Recording of previous events;recruit;Refugees;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk Factors;Science;Scientist;skills;social culture;social science research;Source;success;Targeted Research;Techniques;Time;Training;Training and Infrastructure;training opportunity;Training Programs;Trust;Underrepresented Populations;underserved community;Universities;Work

PROJECT_TITLE: San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: MOORE, ALISON AHERN (contact)

PROJECT_TERMS: Address;Administrative Personnel;Administrator;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Annual Reports;Area;Collaborations;Communication;Communities;Data;Dimensions;education research;Ensure;equity, diversity, and inclusion;Fostering;Funding;Goals;Hispanic;Hispanic-serving Institution;human subject;Individual;Inequity;Infrastructure;innovation;Institution;Intervention;Latino;Leadership;Limited English Proficiency;Longevity;meetings;member;Mentors;Minority;Monitor;multidisciplinary;novel;operation;Operations Research;Outcome;Performance;Pilot Projects;Policies;programs;Recommendation;recruit;Refugees;Research;Research Institute;Resources;Sampling;Scientist;Site Visit;Strategic Planning;Structure;Targeted Research;Training;Training Activity;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BENMARHNIA, TARIK  (contact)

PROJECT_TERMS: Address;Adult;Aging;Agreement;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Applications Grants;Behavioral;career;Catalogs;Characteristics;Code;Cognitive aging;Cohort Studies;Collaborations;Collection;Communities;Consultations;cost;Data;data access;Data Analyses;Data Collection;data resource;Data Set;Data Sources;Development;Disparity;Education;Ensure;Epidemiologic Methods;Feedback;Foundations;Funding;Goals;Grant;Green space;Health behavior;health inequalities;Hispanic Populations;Individual;Inequality;Inequity;innovation;interest;Intervention;Interview;Knowledge;Latino Population;Limited English Proficiency;Linguistics;Manuscripts;Measurement;Measures;Mentorship;Methodology;Methods;Minority;Neighborhoods;Neurocognitive;novel;Paper;Pilot Projects;Policies;Population Heterogeneity;preference;prevent;Principal Investigator;Procedures;Productivity;Protocols documentation;Psychometrics;Publications;Publishing;Qualitative Research;Refugees;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Role;Scientist;skills;social;social epidemiology;social factors;social structure;Source;surveillance data;Targeted Research;Testing;tool;Training;Training Activity;Training and Education;Work

PROJECT_TITLE: Analysis Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE – PUBLIC HEALTH RELEVANCE Autonomic ganglia in the pelvis originate from neural crest progenitors during development although  little is known about the regulatory mechanisms that control diversity of neuron types in these ganglia, which are essential for control of bladder contractility during urination. We propose novel  experimental approaches using a newly developed mouse model that has defects in neural crest  development to determine the genes and mechanisms that are required for formation of the normal  complement of neuron types in pelvic ganglia. These studies will provide greater understanding of  how defects in development of the peripheral nervous system predispose children to abnormal  bladder function while establishing a framework of gene networks that can be used to promote the  formation of normal pelvic neurons for treatment of lower urinary tract disorders.

PI_NAMEs: SOUTHARD-SMITH, E MICHELLE  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Affect;Age;Alleles;Anesthesia procedures;Animals;Autonomic ganglion;Autonomic nervous system;Autopsy;Axon;Biological Assay;Bladder;Bladder Control;Bladder Dysfunction;Catalogs;Cell Lineage;cell type;Cells;Child;Childhood;Coitus;Complement;Coupled;Data;Defect;density;design;Development;Developmental Process;Electric Stimulation;Embryonic Development;Equilibrium;Exhibits;experience;fetal;Functional disorder;Future;Ganglia;ganglion cell;Gene Deletion;Gene Expression Profile;gene network;Genes;genetic testing;Goals;Human;Hypogastric Plexus;Image;Immunohistochemistry;In Situ;Inferior;interest;Knowledge;Label;Laser Scanning Confocal Microscopy;Lower urinary tract;lower urinary tract symptoms;Measures;Mediating;Microscopy;Morphology;Motor Neurons;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;Nerve Fibers;nerve supply;nervous system development;Neural Crest;Neural Tube Defects;Neuroanatomy;neurodevelopment;neurogenesis;neuronal cell body;Neuronal Differentiation;Neurons;novel;Outcomes Research;Patients;Pattern;Pelvis;Peripheral;Peripheral Nervous System;personalized medicine;Phenotype;Physiologic pulse;Physiological;Physiology;Play;Population;postnatal;Prevalence;Process;progenitor;public health relevance;Reaction;Regenerative Medicine;Resolution;response;Rodent;Role;School-Age Population;segregation;sex;single cell sequencing;single-cell RNA sequencing;Site;Spatial Distribution;stem cell migration;Testing;transcription factor;Ureter;urinary bladder neck;Urinary tract;Urination;Urodynamics;Urogenital Sinus;Urologic Diseases

PROJECT_TITLE: Neural crest-derived pelvic ganglia and the effects of developmental deficits on lower urinary tract innervation

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Kidney Disease;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MCEVOY, LINDA KATHLEEN (contact)

PROJECT_TERMS: Address;Adoption;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Auditory Perception;Award;Awareness;barrier to care;Behavior Therapy;Behavioral;Behavioral Research;career;career development;Chronic Kidney Failure;Clinic;Cognitive;cognitive performance;Collection;Communities;community based participatory research;community collaboration;community engaged research;Data;Data Analyses;dementia risk;design;Dissemination and Implementation;Doctor of Philosophy;Education;education research;Ensure;Epidemiologist;equity, diversity, and inclusion;ethnic minority;experience;Faculty;farm worker;Funding;Goals;health inequalities;Hearing Aids;hearing impairment;Hispanic Populations;Impaired cognition;implementation research;improved;Individual;Inequity;innovation;Institution;Intervention;Kidney Diseases;Knowledge;Latino;Latino Population;Leadership;Life Cycle Stages;Limited English Proficiency;Measures;Mentors;Mentorship;Methods;Minority;Minority Groups;Monitor;multidisciplinary;novel;older adult;outcome disparities;Patients;pesticide exposure;Pilot Projects;Positioning Attribute;programs;racial minority;recruit;Refugees;Renal function;Research;Research Design;Research Methodology;Research Personnel;Resources;responsible research conduct;Risk;Risk Reduction;Rural;Sampling;Scientist;screening;sensor;skills;social;Structure;success;synergism;Targeted Research;Techniques;Training;Underrepresented Populations;uptake;Urine;Woman;wristband

PROJECT_TITLE: Research Education Component


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Public Health Relevance Understanding how memories of past experiences are stored and retrieved in the brain is a question with immediate relevance to conditions that affect memory such as Alzheimer's disease, epilepsy, stroke and normal aging, but also to disorders such as schizophrenia and autism for which there is increasing evidence of a link between memory-processing brain systems and functions such as thinking, planning and imagination of future experiences. This proposal aims to take fundamental steps toward establishing a model of memory storage and retrieval, in terms of the way brain cells signal to each other both during active behavior and during rest states. We will perform causal tests of how specific sequenced patterns of activity called "replay" contribute to memory, causal tests of how different circuits are involved in producing these patterns, and advanced measurements of how sequenced patterns in different circuits are synchronized, to provide new insight into a fundamental mechanism of memory.

PI_NAMEs: FOSTER, DAVID J (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Circuit mechanisms of hippocampal replay

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


PI_NAMEs: AL-ROUSAN, TALA  (contact)

PROJECT_TERMS: Active Learning;Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Collaborations;Communities;community academic partnership;community advisory board;community collaboration;community engaged approach;community engaged research;community engagement;community organizations;community partnership;comparison group;Development;Education;education research;Ensure;environmental enrichment for laboratory animals;Equity;experience;Goals;Hispanic;Hispanic Populations;Inequity;Intention;interest;International;Intervention;Latino;Latino Population;Lead;Learning;Limited English Proficiency;Linguistics;Minority;minority communities;Minority Groups;Pilot Projects;Population;population based;recruit;recruitment science;Refugees;Research;Research Personnel;Resources;Risk;Science;Scientist;Strategic Planning;Targeted Research;Training;Training and Education;Trust;Vision;Voice;Work

PROJECT_TITLE: Community Liaison and Recruitment Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE. The molecular mechanisms that drive disease pathogenesis in Alzheimer’s disease (AD) have not been unequivocally identified, and new molecular targets potentially involved in the etiology of AD continue to emerge. We found that levels of GDAP1, a poorly understood protein that regulates cellular redox and mitochondrial morphology in response to oxidative stress, are significantly reduced in the brains of AD patients and AD human induced neurons (iNs), which is consistent with a putative role for GDAP1 in oxidative damage in AD. We will test the hypothesis that GDAP1 detoxifies the toxic product of lipid peroxidation 4HNE,and that reduced GDAP1 levels predispose cells affected by AD to oxidative damage.

PI_NAMEs: KISELYOV, KIRILL  (contact);THATHIAH, AMANTHA ;VANDEMARK, ANDREW PAUL

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 4 hydroxynonenal;abeta accumulation;Address;adduct;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amino Acids;Amyloid beta-Protein Precursor;Antioxidants;Automobile Driving;Autopsy;Binding;Brain;Brain region;Calcium;Calcium Signaling;Cell model;Cells;Charcot-Marie-Tooth Disease;Communication;Complex;Cytoprotection;Data;Data Set;Defect;Disease;Disease Progression;drug candidate;Drug Metabolic Detoxication;Enzymes;Epigenetic Process;Equilibrium;Etiology;Excision;Fibroblasts;GDAP protein;Gene Proteins;Genes;Genetic;Glutathione;Glutathione S-Transferase;HDAC1 gene;Homeostasis;Human;human disease;Induced Neurons;Knowledge;Ligands;Lipid Peroxidation;Lipids;longitudinal positron emission tomography;Maintenance;Maps;Measures;Mediating;member;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Target;Morphology;Motility;mouse model;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;Organelles;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Peripheral Nervous System Diseases;Physiology;Prefrontal Cortex;Protein Isoforms;Proteins;Proteomics;Regulation;Reporting;Research;response;Role;Sampling;Site;Skin;tau aggregation;tau dysfunction;tau Proteins;Testing;Therapeutic Intervention;Time;transcriptome sequencing;transcriptomics;Translating;VDAC1 gene;Xenobiotics

PROJECT_TITLE: Role of mitochondrial GDAP1 in Alzheimer's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE This trial will evaluate the CATSystem - a web-based, system-level intervention that addresses persistent gaps in cervical cancer care by facilitating guideline-adherent services to optimize the cervical cancer screening and treatment cascade of care. This study is designed to evaluate intervention efficacy, implementation optimizations, and assess cost-effectiveness to inform larger scale-up. Cervical cancer is preventable, thus innovative approaches are critically needed in Kenya to improve cervical cancer outcomes.

PI_NAMEs: KESSLER, SARAH FINOCCHARIO (contact);MABACHI, MARIANNE NATABHONA

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Africa;Africa South of the Sahara;Age;Algorithms;antenatal;cancer care;Cancer Etiology;cancer prevention;cancer therapy;Cancerous;Caring;Cervical Cancer Screening;Cessation of life;chemotherapy;Clinical;Cold Therapy;comorbidity;cost;Cost Analysis;cost effective;cost effective intervention;cost effectiveness;Country;COVID-19;Data;design;Disease Outcome;Early Diagnosis;Early treatment;efficacy evaluation;eHealth;Electrocoagulation;Eligibility Determination;Excision;experience;female reproductive tract;follow-up;Goals;Government;Guidelines;Health;high risk;HIV;HIV diagnosis;Hospital Referrals;Hospitals;human centered design;Hysterectomy;implementation strategy;implementation/effectiveness;improved;Incidence;Infant;Information Systems;Infrastructure;innovation;interoperability;Intervention;Invasive Lesion;Kenya;Lesion;Letters;Life;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Monitor;Morbidity - disease rate;mortality;National Cancer Institute;Online Systems;Outcome;patient retention;patient-level barriers;Patients;Pilot Projects;Population;premalignant;prevent;primary outcome;Procedures;Provider;Public Health;public health relevance;Quality-Adjusted Life Years;Randomized, Controlled Trials;Recommendation;reproductive;Resource-limited setting;Risk;Running;scale up;screening;Screening for cancer;Screening Result;secondary outcome;Service provision;Services;Site;social stigma;standard of care;System;system-level barriers;tool;Treatment Efficacy;treatment site;uptake;Visual;Woman;women's diagnosis;Women's mortality;women's treatment;Work;World Health Organization

PROJECT_TITLE: Implementing and Evaluating the Cancer Tracking System (CATSystem): A systems level intervention to improve Cervical Cancer screening, treatment referral and follow up in Kenya

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Narrative This project explores strategies to identify and resolve disparities associated with risk score-based eligibility criteria for medication therapy management (MTM) services in the Enhanced MTM program for Medicare. This project is highly relevant to public health because its long-term goal is to improve health outcomes among the diverse older adult population by reducing disparities in medication utilization. Further, since initiatives by the Centers for Medicare and Medicaid Services usually spur national changes, our study can exert an impact beyond Medicare.

PI_NAMEs: WANG, JUNLING NONE (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;age related;Area;Cessation of life;Chronic;comparative effectiveness;computerized data processing;cost;COVID-19;COVID-19 impact;Data;Data Analyses;data management;Disparity;disparity reduction;Drug Prescriptions;Effectiveness;Eligibility Determination;Emergency department visit;Ensure;Equity;ethnic disparity;ethnic health disparity;Ethnic Population;Exhibits;experience;Fostering;Freedom;Goals;Grant;Health;Health Care Costs;health disparity;Health Resources;health service use;Health Services;Health Status;Hospitalization;improved;Individual;Inequity;innovation;Link;Literature;Machine Learning;machine learning algorithm;Measures;Medicare;Medicare Part A;Medication Management;Modeling;Modification;Morbidity - disease rate;mortality;older adult;Outcome;Outcome Study;Output;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Physicians;Population;Predisposition;prevent;programs;Public Health;Publications;racial disparity;racial population;Ramp;Reporting;Research;Research Personnel;Risk;Services;success;Testing;transfer learning;United States;United States Centers for Medicare and Medicaid Services;Visit

PROJECT_TITLE: Rectifying Disparities Associated with Risk Score-Based MTM Eligibility in Enhanced MTM

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: WALTHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Carbohydrate binding proteins (CBPs) are a broad category of proteins involved diverse biological processes that either guard against disease or that promote it. These proteins are involved in cancer, infectious disease, immunity, autoimmunity, diabetes, and fibrosis, to name a few. This project will develop technologies that enable rapid discovery of CBP inhibitors, which would enable us to treat disease and to untangle the complex web of CBP functions that are currently poorly understood.

PI_NAMEs: KRAUSS, ISAAC JONATHAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Affinity;Allergens;angiogenesis;aptamer;Atherosclerosis;Autoimmunity;Avidity;Bar Codes;Binding;Binding Sites;Biological;Biological Process;C-Type Lectins;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Categories;CD209 gene;Cell Adhesion;chelation;Chemicals;Communicable Diseases;Complex;Defense Mechanisms;desensitization;design;Diabetes Mellitus;Diagnostic;Directed Molecular Evolution;Disease;DNA;Elements;Evolution;Exhibits;Eye;Fibrosis;flexibility;Galactose;Galactose Binding Lectin;Galectin 1;Generations;Geometry;Glycobiology;glycosylation;Goals;Hand;Heart;HIV Antibodies;HIV vaccine;Immunity;immunoregulation;Immunosuppression;in vivo;Individual;inhibitor;interest;Internet;Interruption;langerin;Lectin;Libraries;Ligand Binding;Ligands;Link;Liver;Lung;Macrophage;Malignant Neoplasms;Mannose;Medicine;member;Methods;Modification;Names;non-drug;nuclease;Nucleic Acids;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polymers;Polysaccharides;Process;Property;protein function;Protein-Carbohydrate Interaction;Proteins;rapid technique;Research;Resistance;response;Rheumatoid Arthritis;RNA;Role;scaffold;Serum;sialic acid binding Ig-like lectin;Sialic Acids;Signal Transduction;small molecule;Specificity;sugar;Technology;Testing;therapeutic development;tool;Validation;Variant;Vertebral column;Viral;Virus Diseases;Work

PROJECT_TITLE: Technologies for Directed Evolution of Glycoaptamers

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Environmental conditions determine if and how individuals interact with one another; yet the complexity of the nervous system of mammals such as mice and humans has limited a mechanistic understanding of how environmental influences shape sensory processing and social behavior. This project is designed to leverage natural variation in the simple nervous system of Drosophila to reveal the mechanistic basis of environmental control over social behaviors. The work will help inform our understanding of neuropsychiatric conditions such as depression, autism and schizophrenia, characterized by the deficiency to appropriately process environmental cues.

PI_NAMEs: BRAND, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;Advisory Committees;Anatomy;Architecture;autism spectrum disorder;Award;Bacteria;Behavior;Behavior Control;Behavioral;Biology;Birds;Brain;Brain imaging;career development;Chemicals;Code;comparative;Copulation;Courtship;Cues;Decision Making;design;Development Plans;Drosophila genus;Drosophila melanogaster;Ecology;Elements;Environment;Ethology;Exposure to;Failure;Female;fly;Food;Functional Imaging;Genetic Complementation Test;Goals;Human;Image;in vivo;Individual;insight;Interneurons;Light;Link;male;Mammals;mating behavior;Mental Depression;Mentors;Mentorship;microbial;microorganism;Modeling;multimodality;Mus;Nervous System;neural;neural circuit;Neuroanatomy;neurogenetics;neuromechanism;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel;Odors;Olfactory Pathways;operation;optogenetics;Partner in relationship;Perception;Phase;Pheromone;Play;Population;Population Control;Positioning Attribute;preference;Probability;Process;Psychology;Regulation;Reproductive Behavior;Research;Resources;Role;Ruta;Schizophrenia;Sensory;sensory input;sensory integration;Sex Attractants;Shapes;Signal Transduction;skills;social;Social Behavior;Social Controls;Social Environment;social group;Social Interaction;Stimulus;System;Techniques;Testing;Traction;Training;Translating;Universities;Variant;virtual reality;virtual reality system;Visual;Visual Pathways;Volatilization;Wolbachia;Work

PROJECT_TITLE: Functional mechanisms of environmental control over social behavior


ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Overall Project Narrative The University of Southern California’s Alzheimer’s Disease and Alzheimer’s Disease Related Dementias Resource Center for Minority Aging Research (USC AD/ADRD RCMAR) brings a distinct capacity for integrating theories and tools from myriad disciplines including but not limited to economics, sociology, and gerontology, using large, complex data sets, and applying rigorous panel data and quasi-experimental methods to generate innovative AD/ADRD disparities research. Our interdisciplinary faculty have the support and expertise to advance research in our focus area: pathways by which social, behavioral and economic factors, and policies and health systems affect disparities in risk of AD/ADRD, and affect disparities in the health, health care and economic outcomes of persons living with dementia. We build upon our successful 10-year history and bring together the infrastructure, leadership, interdisciplinary expertise and resources to: (1) increase the number, diversity, and scholarly achievements of scholars of dementia health equity research and; (2) develop new, innovative lines of research to advance dementia health equity.

PI_NAMEs: AGUILA, EMMA ;AILSHIRE, JENNIFER A;ZISSIMOPOULOS, JULIE M (contact)

PROJECT_TERMS: Achievement;Address;advanced dementia;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Award;Behavior Therapy;Behavioral;biodemography;Black American;California;care outcomes;career;Career Choice;career development;caregiving;Caring;Cognitive;Collaborations;college;Communication;Communities;complex data;Data;Data Set;Data Sources;Dementia;dementia burden;dementia care;Development;disadvantaged background;disadvantaged women;Discipline;Disparity;Economic Factors;economic outcome;Economics;education research;Ensure;Ethnic Population;Evaluation;experience;Faculty;Funding;Gerontology;Goals;Health;Health Disparities Research;health disparity;health economics;health equity;Health equity research;health inequalities;Health Policy;Health system;Hispanic;Hispanic Americans;Historically Black Colleges and Universities;Impaired cognition;improved;Inequity;Infrastructure;innovation;Institution;K-Series Research Career Programs;Latinx;Leadership;Medicine;Mentors;Mentorship;Methods;Minority;Minority-Serving Institution;National Institute on Aging;Outcome;Pathway interactions;Persons;Pilot Projects;Policies;Population;population health;Positioning Attribute;Prevention;Productivity;Publishing;Quasi-experiment;Race;racial population;Recording of previous events;Reduce health disparities;Research;Research Personnel;Research Support;Resources;Scholars Program;Schools;Scientist;social;social science research;sociodemographics;Sociology;Subgroup;System;Technology;theories;tool;Underrepresented Minority;Universities;visiting scholar;Woman

PROJECT_TITLE: University of Southern California Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) Resource Center for Minority Aging Research (USC AD/ADRD RCMAR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ZISSIMOPOULOS, JULIE M (contact)

PROJECT_TERMS: Achievement;Address;advanced dementia;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavior Therapy;Behavioral;biodemography;Biological Sciences;California;care outcomes;career;Clinical Sciences;Collaborations;college;Communication;Communities;complex data;Country;Data;Data Set;Dedications;Dementia;dementia burden;design;Discipline;Disparity;Economic Factors;economic outcome;Economics;education research;Educational workshop;Ensure;Ethnic Population;Faculty;Feedback;Funding;Gerontology;Goals;Health;health disparity;health economics;health equity;Health equity research;Health Policy;Health system;healthy aging;Hispanic;Historically Black Colleges and Universities;Home;Impaired cognition;improved;Indiana;Individual;Inequity;Infrastructure;innovation;Institution;K-Series Research Career Programs;Latinx;Leadership;Learning;Mentors;Mentorship;Methods;Minority;Minority-Serving Institution;Mission;pandemic disease;Pathway interactions;Peer Review;Persons;Policies;population health;Positioning Attribute;Principal Investigator;Privatization;programs;Publications;Publishing;Quasi-experiment;Race;Recording of previous events;Research;Research Personnel;Research Proposals;Research Support;Resources;Role;Scholarship;Schools;Science;Scientist;social;Societies;sociodemographics;Sociology;South Carolina;Structure;success;support tools;theories;tool;Twitter;Underrepresented Minority;Universities;Update


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JACOBSON, MIREILLE  (contact)

PROJECT_TERMS: Achievement;advanced dementia;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical method;Area;Behavior Therapy;Behavioral;behavioral economics;biodemography;Biological;California;care outcomes;career;Caregivers;Catalogs;college;Communities;Complex;complex data;Consultations;Data;data infrastructure;data resource;Data Set;Data Sources;Databases;Dementia;dementia burden;dementia risk;Discipline;Disparity;Economic Factors;economic outcome;Economics;Educational workshop;Elderly;Ensure;Environmental Risk Factor;Equity;Ethnic Population;Faculty;Funding;Future;Gerontology;Goals;Health;health disparity;health economics;health equity;Health equity research;health inequalities;Health Policy;Health system;Healthcare;Hispanic;Historically Black Colleges and Universities;Inequity;Infrastructure;innovation;insight;Institution;Internet;large datasets;Latinx;Lead;Leadership;Link;Longitudinal Surveys;Medicaid;Medicare;Mentors;Methodology;Methods;Minority;Modeling;models and simulation;novel;Outcome;Pathway interactions;Persons;Pilot Projects;Policies;population health;Population Research;Positioning Attribute;programs;Publications;Quasi-experiment;Race;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;Schools;Scientist;Services;Shapes;simulation;social;Social Sciences;sociodemographics;Sociology;success;Surveys;theories;tool;Training;training opportunity;Universities;Visit;web site


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW ORLEANS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE Sympathetic nervous activity alters the function of all major organ systems and impairments in sympathetic function are involved in the leading causes of death in the US (heart disease, cancer, diabetes). Recent work indicates that the autonomic and immune systems closely interact. This proposal will test the hypothesis that macrophages, a type of immune cell, are critical in controlling sympathetic activity.

PI_NAMEs: WHIM, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acute;Adrenal Glands;Adrenal Medulla;Autonomic Dysfunction;Autonomic nervous system;Blood Glucose;Blood Pressure;Body System;Body Temperature;Catecholamines;Cause of Death;Cell secretion;Cells;cellular targeting;cholinergic;Chromaffin Cells;Circulation;clinically significant;designer receptors exclusively activated by designer drugs;Diabetes Mellitus;Disease;Dysautonomias;Electrophysiology (science);Enzymes;Epinephrine;Etiology;experimental study;Exposure to;Fasting;fighting;Genetic;genetic approach;Heart Diseases;Homeostasis;Hormones;Hypertension;Hypoglycemia;Hypotension;Immune;immune function;Immune system;Impairment;in vivo;Inflammation;Insulin-Dependent Diabetes Mellitus;Macrophage;Malignant Neoplasms;Modeling;Molecular;Molecular Target;mouse model;Mus;Neuroimmune;Neurons;neuropeptide Y;Norepinephrine;Organ;Output;Paracrine Communication;Physiological;Population;postsynaptic;presynaptic;prevent;Process;Reflex action;Respiration;response;Role;Signal Pathway;Signal Transduction;Site;Sympathetic Nervous System;Synapses;System;Testing;Time;Tissues;Tyrosine 3-Monooxygenase;Work

PROJECT_TITLE: Modulation of Sympatho-Adrenal Function by Tissue Resident Macrophages

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PI_NAMEs: CRIMMINS, EILEEN M (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Arts;Award;Behavior Therapy;Behavioral;California;career;career development;Classification;cohort;Collaborations;college;Complex;complex data;Data;Data Sources;Dedications;Dementia;dementia burden;Demography;Development;Discipline;disease disparity;Disparity;Economics;education research;Educational Curriculum;Engineering;Ensure;Environment;Epidemiology;Ethics;expectation;experience;Faculty;Feedback;Funding;Gerontology;Goals;Grant;Health;health economics;Health Policy;Hispanic-serving Institution;Historically Black Colleges and Universities;Impaired cognition;improved;Inequity;Infrastructure;innovation;Institution;Investigator-Initiated Research;Laws;Leadership;Letters;Medicine;member;Mentors;Mentorship;Methods;Minority;Minority-Serving Institution;multidisciplinary;Occupations;Outcome;Pathway interactions;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;Privatization;Process;Productivity;programs;Public Policy;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientist;Secure;social;Social Work;Sociology;Subgroup;success;theories;Time;tool;tool development;Training;Underrepresented Populations;Universities;Work


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The goal of this project is to build an integrated computational and experimental platform for mapping functional dynamics within tissue to a high-resolution atlas of its molecular and cellular composition. Such a method will link structure with function at both high breadth in coverage — measuring a large fraction of all single cells in a given tissue region — and high molecular depth, by leveraging complementary genomic datasets to guide adaptive rounds of increasingly detailed imaging.

PI_NAMEs: MILLER, MILES A (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Anatomy;Atlases;Behavior;Binding;Biological;biological systems;Blood Vessels;cancer cell;cell behavior;cell community;cell motility;cell type;Cells;cellular imaging;Cellular Morphology;Cellular Structures;Characteristics;Chemicals;Circulation;Complex;computational pipelines;computational platform;Computer Analysis;Computing Methodologies;Confocal Microscopy;Data;design;Development;Disease;Disease Progression;Excision;Explosion;Face;Genetic Engineering;genomic data;Goals;Health;Heart;Human;Image;Imaging technology;Immune;Immunologics;improved;In Vitro;in vivo;in vivo imaging;Infiltration;intravital microscopy;Ischemia;Knowledge;Length;Leukocytes;Link;Liquid substance;Macrophage;Maps;mast cell;Measures;Melanoma;Methods;Microscopy;migration;Mining;Modeling;Molecular;molecular marker;Molecular Profiling;molecular subtypes;Monitor;Morphology;mouse model;Movement;multiplexed imaging;Myeloid Cells;Myocardial Infarction;Neoplasm Metastasis;neutrophil;new technology;novel strategies;Nucleic Acids;Operative Surgical Procedures;Pericytes;Pharmaceutical Preparations;Pharmacodynamics;Phase;Physiological;Population;Process;Proteins;Proteomics;Reperfusion Injury;Resolution;response;sample fixation;Sampling;single-cell RNA sequencing;small molecule;Stains;Structure;System;Techniques;Technology;technology validation;Tissue atlas;Tissue imaging;Tissues;tool;Translating;tumor;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vesicle;Visualization

PROJECT_TITLE: Molecular profiling of global tissue dynamics at sub cellular resolution

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: GRAMERCY RESEARCH GROUP, LLC

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE The results will have an important public health impact, as significant changes in PA can reduce the risk of coronary heart disease, hypertension, type 2 diabetes, and stroke by 15-40%, avoid 263,000 deaths each year, and result in life expectancy gains of 1.5-3.5 years in this population.

PI_NAMEs: NEWTON, ROBERT LEE;WHITT-GLOVER, MELICIA C (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advertising;Advisory Committees;Black Populations;black women;Cessation of life;Child Care;Chronic Disease;Clinical Markers;Communication;Coronary heart disease;Data;Data Collection;Development;Disease Marker;Educational Curriculum;effective intervention;Effectiveness;efficacy study;Eligibility Determination;Enrollment;ethnic minority population;Evaluation;Evidence based program;Exercise;exercise intervention;exercise program;Faith;faith-based intervention;feasibility testing;Feedback;field study;flexibility;Focus Groups;Goals;Group Meetings;Guidelines;Health;high risk population;Home;Household;Hypertension;improved;Individual;interest;Internet;internet delivery;Intervention;intervention delivery;Knowledge;Life Expectancy;Location;member;Methods;Modeling;Non-Insulin-Dependent Diabetes Mellitus;online course;online delivery;Participant;Persons;Phase;Physical activity;Population;post intervention;premature;Premature Mortality;Prevention;primary outcome;Principal Investigator;programs;Public Health;public health relevance;racial minority population;Radio;Randomized;Recommendation;recruit;Religion;Reporting;Research;Risk Reduction;Sampling;Schedule;secondary outcome;Self Efficacy;social media;Social support;Spirituality;Stroke;Target Populations;Television;Testing;Translations;Woman;Work

PROJECT_TITLE: Feasibility and acceptability of an online program to promote physical activity among black women

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Health Effects of Indoor Air Pollution

ORG_CITY: GOLDEN

ORG_NAME: TDA RESEARCH, INC.

ORG_STATE: CO

PHR: Project Narrative/Public Health Relevance Per- and polyfluoroalkyl substances (PFAS) are emerging environmental pollutants in drinking and groundwater and the EPA estimates that the drinking water of more than 110 million Americans may already be contaminated with PFAS. Epidemiological studies have shown that the occurrence of PFAS in humans is probably linked to a high incidence of thyroid disease, high cholesterol, ulcerative colitis, kidney cancer, testicular cancer, and pregnancy- induced hypertension. TDA Research, Inc (TDA) proposes to develop an adsorption-based system for removing PFAS from drinking water down to EPA prescribed limits of 70 ppt and the even lower limits (10 ppt or less) expected in the future. 15

PI_NAMEs: DIETZ, STEVEN D (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acids;Adsorption;Air;American;aqueous;Area;Attention;Aviation;base;Beds;bioaccumulation;Carbon;Carpet;Certification;Chemicals;Chemistry;Chlorine;Cholesterol;Collaborations;consumer product;contaminated water;cost;cost effective;design;design and construction;drinking;drinking water;economic evaluation;Economics;Electronics;Environment;Environmental Pollutants;epidemiology study;Equipment;Evaluation;Excision;exposed human population;Exposure to;Family;Filtration;Food Packaging;Foundations;functional group;Future;Government;ground water;Health;Home;Human;improved;Incidence;Individual;Industrialization;Industry;Kinetics;Life;Link;Location;Malignant neoplasm of testis;man;manufacture;Marketing;Names;New York;perfluorooctane sulfonate;perfluorooctanoic acid;Persons;Pesticides;Pharmacologic Substance;Phase;Plant Resins;Poly-fluoroalkyl substances;pregnancy hypertension;Probability;Procedures;Process;Production;prototype;public health relevance;Regulation;Renal Carcinoma;Research;Sampling;Sanitation;scale up;Series;Site;Small Business Innovation Research Grant;Solvents;Structure;Sunlight;Surface;System;Technology;Teflon;Test Result;Testing;Thyroid Diseases;Toxic effect;Travel;Ulcerative Colitis;Water;Water Purification;Water Supply;water treatment;Work

PROJECT_TITLE: Filtration Media for In-Home PFAS Removal from Drinking Water


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Extended periods of musculoskeletal disuse and unloading, such as found during paralysis, bedrest, and or spaceflight, increase the risk of bone and muscle weakness and fragility fracture. Treatment options for patients with fractures during musculoskeletal disuse are limited because very little is known about how mechanical loads (or lack thereof) are sensed by different bone cell populations to regulate healing. This project seeks to use a controllable muscle and bone loading platform to identify what mechanical interventions and molecular mechanisms are necessary to improve fracture healing and muscle strength during extended disuse.

PI_NAMEs: BUETTMANN, EVAN G (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acute;Affect;Aging;angiogenesis;Attenuated;Award;Bed rest;Bioinformatics;Biomechanics;Blood Vessels;bone;Bone callus;bone cell;bone fracture repair;bone healing;Bone Injury;bone loss;bone mass;Bone Regeneration;bone repair;Burn injury;career;Cell Lineage;cell type;Cells;Clinical;Coupling;Data;deprivation;Development;Diabetes Mellitus;Disease;Down-Regulation;Electric Stimulation;Environment;fall risk;falls;Flow Cytometry;Fracture;fracture risk;fragility fracture;Genes;Genetic;Genetic Engineering;Grant;healing;Health;high risk;Hindlimb Suspension;Hormonal;Impairment;improved;In Vitro;in vivo;Incidence;Individual;insight;Intervention;Knowledge;Light;limb bone;mechanical load;Mechanics;Mediator;Mentors;Modality;Modeling;Molecular;mortality;mouse model;Mus;Muscle;Muscle Contraction;muscle form;muscle strength;Muscle Weakness;Muscular Atrophy;Musculoskeletal;Obesity;optogenetics;Osteoblasts;osteoclastogenesis;Osteocytes;Osteogenesis;osteogenic;osteoimmunology;Outcome;Pain;Paralysed;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Physical Rehabilitation;Physiologic pulse;Population;Pre-Clinical Model;Process;protein activation;Proteins;radiological imaging;Recovery;reduced muscle mass;Regimen;Rehabilitation therapy;repaired;Reporting;Research;Risk;Role;Signal Transduction;skeletal;Skeletal Muscle;skeletal muscle wasting;skills;Space Flight;stem cell proliferation;targeted treatment;Techniques;Testing;Tissues;Training;Transcript;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome sequencing;Verteporfin;virtual;Weight-Bearing state;Work

PROJECT_TITLE: Mechanobiology of fracture healing during skeletal disuse

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases;Telehealth;Wound Healing and Care

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: PROJECT NARRATIVE While the prevalence of skin diseases are very high in LMICs, especially in children, dermatological services in LMICs are lacking mainly due to lack of clinical skills, and further, ways to document and store clinical course which is important for individual patient follow-up do not exist. If there is a field-adapted platform for data collection and sharing for skin conditions allowing clinical decision support for healthcare providers onsite, and remotely through teledermatology, this could serve as a breakthrough to management of skin diseases in this underserved populations. In this project, we will complete the development and optimization of a powerful and comprehensive, but easy-to-use smartphone / tablet application tool that addresses these gaps, envisioning Skin Health for All.

PI_NAMEs: YOTSU, RIE  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;African;Algorithms;Area;Artificial Intelligence;Buruli Ulcer;Caring;Case Management;Cellular Phone;Child;Clinical;clinical decision support;Clinical effectiveness;Clinical Skills;Collaborations;Collection;Communities;Country;Darkness;Data;Data Collection;data platform;data sharing;Decision Support Systems;Deformity;Dermatologic;Dermatologist;Dermatology;design;Detection;Development;Diagnosis;Diagnostic;digital;digital health;Disease Outcome;disorder control;Early Diagnosis;Early treatment;Economics;Education;effectiveness study;Epidemiologic Monitoring;Equipment;experience;Family;Filarial Elephantiases;follow-up;Future;Goals;Health;Health Personnel;health training;Healthcare;Image;Impact evaluation;improved;Individual;individual patient;Infectious Skin Diseases;innovation;intelligent diagnosis;Intervention;Interview;Ivory Coast;Japan;Left;Leprosy;Lesion;Lifelong disability;low and middle-income countries;Measures;Medical;meetings;member;Methodology;mHealth;neglected tropical diseases;novel;Outcome;Patients;Performance;Phase;Photography;physically handicapped;pilot trial;portability;Prevalence;Process;prototype;Psyche structure;Recording of previous events;Records;Remote Consultation;Research;Research Personnel;Rural;Series;Services;sharing platform;Site;skills;Skin;skin color;skin disorder;skin lesion;Skin Manifestations;social;Specialist;Standardization;support tools;Surveys;System;Tablets;Technology;teledermatology;Telemedicine;tool;Training;Treatment outcome;Tropical Medicine;two-arm study;Underserved Population;Universities;usability;Validation;Visual;Work;World Health Organization;wound;wound care;wound healing;wound treatment;Yaws

PROJECT_TITLE: MIND-the-SKIN Project: Multi-functional Innovative Digital Toolkit for the Skin Diseases in LMICs and Beyond


ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The burden of Alzheimer’s disease (AD) and AD-related dementias (ADRD) falls disproportionately on the populations of older adults who are from under-represented backgrounds. Research on minority aging to understand racial/ethnic disparities in AD/ADRD and to develop interventions and preventive strategies to reduce cognitive impairment and dementia risk is urgently needed. A goal of this renewal Johns Hopkins Alzheimer’s Disease Resource Center for Minority Aging Research application is to train and support early- stage investigators from diverse backgrounds who are carrying out ADRD-relevant research that supports cognitive health and well-being in older adults from under-represented backgrounds.

PI_NAMEs: GALLO, JOSEPH JOHN;THORPE, ROLAND J. (contact)

PROJECT_TERMS: Address;Advisory Committees;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian Indian;Attention;Behavioral;Biological;black men;Black race;care providers;career;Caring;Cognitive;Collaborations;collaborative environment;Communities;community engagement;community organizations;community-level factor;comorbidity;Dementia;dementia caregiving;dementia risk;Detection;Development;Discipline of Nursing;Disparity;disparity reduction;Education;education research;Ensure;Epidemic;Epidemiology;ethnic disparity;ethnic diversity;experience;Faculty;Faith;falls;Family;Family Caregiver;Fostering;Foundations;Goals;Health;Health Disparities Research;health disparity;Health protection;high risk;Historically Black Colleges and Universities;Impaired cognition;India;Individual;innovation;Intervention;Intervention Studies;investigator training;Knowledge;late life;Leadership;Legal;Life Cycle Stages;Maintenance;medical schools;member;Mentors;Methodology;Methods;Minority;minority health;Minority Health Research;Minority-Serving Institution;Neighborhoods;Not Hispanic or Latino;older adult;Older Population;Parents;Personal Satisfaction;Pilot Projects;Population;prevent;Prevention strategy;Preventive;primary care practice;programs;Public Health;racial disparity;racial diversity;recruit;Research;Research Methodology;Research Personnel;Research Support;Resources;response;Risk Factors;role model;Schools;Scientist;service delivery;social factors;Social Network;Structure;Training;Underrepresented Populations;Universities;Work

PROJECT_TITLE: The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: THORPE, ROLAND J. (contact)

PROJECT_TERMS: Accountability;Adherence;Advisory Committees;African American;African American population;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian Americans;Behavioral;behavioral and social science;career;Communication;Communities;community organizations;Country;Data Collection;Development;Discipline of Nursing;Disparity;disparity reduction;education research;Effectiveness;Ensure;Environment;Epidemic;ethnic diversity;Evaluation;experience;Faculty;Fostering;functional decline;Funding;Goals;Grant;health disparity;Hispanic Americans;Historically Black Colleges and Universities;Human;Impaired cognition;Intervention;Intervention Studies;Leadership;Medicine;Mentors;Methodology;Minority;Minority-Serving Institution;Monitor;Not Hispanic or Latino;Observational Study;older adult;Participant;Pilot Projects;Population;prevent;Productivity;programs;Public Health;Public Health Schools;Publications;Quality Control;racial disparity;racial diversity;recruit;Reporting;Research;Research Personnel;Resources;response;Risk Reduction;Scientist;social;social science research;Structure;Supervision;timeline;Training;Underrepresented Minority;United States;Universities;web site;Work

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE As the prevalence of fentanyl continues to rise, there is an urgent need to better understand how we can successfully engage more people in treatment that decreases morbidity and mortality related to opioid use disorder. The work described in this K23 application will investigate the initiation of buprenorphine in the setting of fentanyl use from both the patient and provider perspectives. We will utilize novel methods to develop and pilot a buprenorphine initiation toolkit.

PI_NAMEs: BHATRAJU, ELENORE  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Absence of pain sensation;addiction;Award;Awareness;Buprenorphine;career;Caring;Certification;Cessation of life;Clinical;Communities;Complex;Consensus;Counseling;Country;Data;Data Collection;Dose;Effectiveness;effectiveness/implementation study;Enrollment;evidence base;experience;Failure;FDA approved;feasibility testing;Feedback;Fentanyl;fentanyl use;Funding;Future;Goals;Hospitals;implementation barriers;implementation evaluation;implementation facilitators;implementation science;improved;improved outcome;Individual;innovation;Inpatients;Interview;Life;lipophilicity;Literature;Medical center;medication for opioid use disorder;Methadone;Methods;Morbidity - disease rate;mortality;multidisciplinary;Naltrexone;Nature;novel;Opioid;Opioid agonist;opioid use;opioid use disorder;Outcome;Outpatients;overdose death;Patient Care;Patients;Penetration;Persons;Pharmaceutical Preparations;Phase;Physicians;Pilot Projects;Practice Guidelines;preference;Preparation;Prevalence;Procedures;Process;Provider;provider factors;Qualitative Methods;Qualitative Research;Randomized;Reaction;recruit;relative effectiveness;Research;Research Methodology;Research Personnel;Research Support;Research Training;response;Review Literature;Risk;Rural;Safety;safety net;Secondary to;Substance Use Disorder;Time;tool;Training;Treatment Failure;Ventilatory Depression;virtual;Waiting Lists;Withdrawal;Work

PROJECT_TITLE: Building and Implementing Best Practices for Buprenorphine Initiation in the Setting of Fentanyl Use

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LEOUTSAKOS, JEANNIE-MARIE SHEPPARD (contact)

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Biometry;Capsicum;Cessation of life;Characteristics;Clinical;Cognitive;cognitive function;cohort;Collaborations;Communication;Communities;community intervention;Complement;Complex;Data;data acquisition;Data Analyses;data management;Dedications;dementia risk;design;Economics;education research;Educational process of instructing;Effectiveness;Environment;Environmental Exposure;ethnic minority;Etiology;Evidence based practice;experience;faculty support;Genetic;Gerontology;Goals;Health;Health Disparities Research;health disparity;health equity;Impaired cognition;implementation research;improved;Individual;Inequality;Infrastructure;Intervention;Knowledge;late life;Leadership;life span;Measures;Mentors;Methodology;Methods;Minority;Modeling;Modernization;Modification;multiple data sources;next generation;Observational Study;older adult;Organizational Culture;Outcome Measure;Persons;Population Heterogeneity;Positioning Attribute;Proxy;racial minority;recruit;Research;Research Design;Research Personnel;Resources;response;Risk;Risk Factors;Scientist;skills;social;Social Network;Statistical Data Interpretation;Structural Racism;Technology;temporal measurement;Testing;therapy development;Time;tool;Translating;translational study;web site;Work

PROJECT_TITLE: Analysis Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Precision Medicine;Stroke

PHR: RELEVANCE Ischemic stroke accounts for the vast majority of acute stroke cases and constitutes a leading cause of deaths among adults and permanent disabilities in survivors. The overall narrow treatment windows and potential risks largely limit the patient eligibility for the current thrombolytic therapy and mechanical thrombectomy, and thus identification of new drug targets is urgently needed to innovate and diversity the treatment of this devastating emergency. The proposed research will develop novel drug-like antagonists for the EP2 receptor, an emerging therapeutic target for brain ischemia-promoted neuroinflammation, and may lead to a new strategy to treat ischemic stroke and subsequent behavioral deficits.

PI_NAMEs: JIANG, JIANXIONG  (contact);LIU, JIAWANG

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Ablation;acute stroke;Adult;Affinity;Alteplase;alternative treatment;Anabolism;analog;Animals;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Anxiety;aqueous;Arteries;Behavioral;behavioral outcome;Binding;Biological Availability;Brain;Brain Injuries;Brain Ischemia;Cardiovascular system;Cause of Death;Cell Death Induction;Cell Line;cell type;Cerebral Ischemia;cerebroprotection;Cerebrovascular system;Chemicals;Cognition;Corpus striatum structure;Coupled;Coxibs;cyclooxygenase 2;cytokine;Cytokine Suppression;Cytoprotection;cytotoxicity;Darkness;deprivation;Development;Dinoprostone;Dose;drug clearance;drug development;drug distribution;effective therapy;Eligibility Determination;Emergency Situation;Encephalitis;enzyme biosynthesis;Enzymes;excitotoxicity;Formulation;Future;Glucose;Goals;GTP-Binding Protein alpha Subunits, Gs;Half-Life;Human;Impairment;improved;In Vitro;in vivo;Infarction;Inflammatory;innovation;Intravenous;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;Isoenzymes;Lead;lead optimization;Leucocytic infiltrate;Lifelong disability;Light;Liver Microsomes;Measures;Mechanics;Mediating;Metabolic;meter;Microglia;Middle Cerebral Artery Occlusion;Modeling;Motor;mouse model;Mus;Neuroglia;neuroinflammation;Neurologic;Neurons;neuropathology;neuroprotection;neurotoxicity;new therapeutic target;novel;novel strategies;novel therapeutics;object recognition;oxygen compounds;Pathogenicity;Pathway interactions;patient subsets;Patients;Penetration;Permeability;Pharmaceutical Preparations;pharmacologic;Phase;Plasma;postnatal;pre-clinical;Pre-Clinical Model;prevent;Prostaglandin Receptor;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Protein Isoforms;radioligand;rational design;receptor;Recommendation;Reperfusion Therapy;Research;Risk;Role;Safety;scaffold;Signal Transduction;small molecule;Solubility;stroke model;Survivors;Testing;Therapeutic Effect;therapeutic target;Thrombectomy;thrombolysis;Thrombolytic Therapy;Vascular System;water solubility

PROJECT_TITLE: EP2 Antagonists for Ischemic Stroke

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: ALBERT, MARILYN S. (contact)

PROJECT_TERMS: Address;Adult;Advanced Development;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Annual Reports;Applications Grants;Area;Behavioral;care providers;career;Cognitive;Collaborations;Communities;Community Developments;community intervention;Data;Dementia;dementia risk;Development;Diagnostic;disparity elimination;education research;Educational Curriculum;Educational process of instructing;Environment;Epidemiology;Evaluation Research;Evolution;Extramural Activities;Faculty;Funding;Goals;Grant;Health;health application;health disparity;health equity;Health Promotion;Health system;Impaired cognition;improved;Infrastructure;innovation;Intervention;Journals;K-Series Research Career Programs;Leadership;Life Cycle Stages;Mentors;Mentorship;Minority;Minority Groups;minority investigator;Modeling;next generation;novel;novel strategies;older adult;Paper;Peer Review;Pilot Projects;Policies;Positioning Attribute;prevent;Procedures;Process;programs;Publications;recruit;Research;Research Personnel;Research Training;Resources;retention rate;Science;Scientist;skills;social factors;Structural Racism;Structure;success;summer program;Testing;therapy design;Time;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: Research Education Component


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Intracortical microstimulation (ICMS) is a versatile tool to study the fundamental physiology of the nervous system and restore sensation in neuroprosthetics; however, the basic neurobiological mechanisms, with relation to which cell types are activated, in what spatiotemporal activation, and how they contribute to therapeutic efficacy remain poorly understood. There has been an increased appreciation of astrocytes' contribution to regulating proper coordination of neural activity during sensory processing, but it still remains unclear how astrocytes respond to ICMS on a network level and how their activation modulates neuronal activity. Using a combination of two-photon microscopy, mesoscale imaging, and optogenetics or genetic manipulation of astrocyte calcium activity, this proposal aims to determine the dynamic relationship between astrocyte and neuronal calcium activity during ICMS and understand how astrocytes respond to and may contribute to the therapeutic efficacy of ICMS paradigms.

PI_NAMEs: STIEGER, KEVIN  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;adeno-associated viral vector;Animals;Astrocytes;awake;Basic Science;Brain;Ca(2+)-Transporting ATPase;Calcium;career;Cell membrane;cell type;Cells;Clinical;clinically relevant;Communication;Coupled;Deep Brain Stimulation;design;Electric Stimulation;Electrodes;Esthesia;Frequencies;Funding;genetic manipulation;Goals;GTP-Binding Proteins;Image;imaging approach;Impairment;Implant;Implanted Electrodes;improved;in vivo;Induced Neurons;insight;interest;Intervention;Knowledge;melanopsin;Microelectrodes;microstimulation;Multimodal Imaging;multimodality;Mus;Nervous System Disorder;Nervous System Physiology;neural;neurobiological mechanism;Neurobiology;Neuroglia;neuronal cell body;Neurons;neuroprosthesis;Neurosciences;Neurosciences Research;Neurostimulation procedures of spinal cord tissue;neurotransmitter release;Neurotransmitters;novel;Opsin;optical imaging;optogenetics;Outcome;Pattern;Physiologic pulse;Physiological;Play;Property;Regulation;Research;response;restoration;Role;Sensory;sensory feedback;sight for the blind;sight restoration;spatiotemporal;stem;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Techniques;Therapeutic;therapeutic target;therapy outcome;Time;tool;Treatment Efficacy;two photon microscopy;two-photon;Viral;Work

PROJECT_TITLE: Astrocyte-Neuron Network Activity During In Vivo Brain Stimulation


PI_NAMEs: SAMUS, QUINCY MILES (contact)

PROJECT_TERMS: Address;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Assessment tool;Attention;behavioral and social science;Caring;Clinical;Collaborations;Communication;Communities;community academic partnership;community based participatory approach;community based participatory research;community collaboration;community engaged research;Community Health;Community Healthcare;community organizations;Community Participation;community partners;Data;Data Analyses;Decision Making;dementia risk;design;Development;Dimensions;education research;Effectiveness;Environment;Ethics;evidence base;Evidence based intervention;Faith;Future;Goals;Growth;Health;health disparity;Healthcare;Historically Black Colleges and Universities;Hybrids;Impaired cognition;improved;Infrastructure;Institute of Medicine (U.S.);Intervention;Leadership;Link;Maintenance;member;Minority;Modeling;older adult;Older Population;Outcome;Participant;Patients;Personal Satisfaction;Persons;Phase;preference;Prevention strategy;preventive intervention;Primary Care;Process;programs;Public Health;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Scientist;social science research;therapy design;Thinking;Training;translational pipeline;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Community Liason and Recruitment Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Pediatric;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative This project will validate the clinical accuracy of an ab-initio physiomarker measured by flexible, wearable sensors in predicting aneurysm growth and dissection. It will allow health care practitioners to more accurately and safely make clinical decisions in recommending treatment for a patient's developing aortopathy; this will reduce the risk of sudden aneurysm rupture and potential mortality incurred by a reactive diagnostic strategy. Moreover, validating the accuracy of the stand-alone wearable sensor platform in measuring the physiomarker may lead to a new paradigm of at-home aneurysm monitoring, as well as enable screening for this aortopathy during patients' routine health checkups.

PI_NAMEs: ZHAO, TOM YU (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: 4D MRI;Abdominal Aortic Aneurysm;Affect;Aneurysm;Angiography;Aorta;Aortic Aneurysm;aortic valve;Area Under Curve;Automobile Driving;bicuspid aortic valve;Biomechanics;Biosensor;Blood flow;Blood Pressure Monitors;Blood Vessel Prosthesis;Blood Vessels;Blood Viscosity;checkup examination;Clinical;clinical decision-making;cohort;comorbidity;Coupling;Data;Data Collection;Death Rate;Development;Diagnosis;diagnostic strategy;Diameter;Dissection;Echocardiography;Encapsulated;Evaluation;Evolution;Exclusion Criteria;Exhibits;Experimental Models;experimental study;flexibility;follow-up;General Population;Growth;Health;Healthcare;hemodynamics;Home;Human body;Hypertension;Image;In Vitro;in-vivo diagnostics;inclusion criteria;individual patient;Intervention;Judgment;kinematics;Liquid substance;Location;Magnetic Resonance Imaging;Marfan Syndrome;Measurement;Measures;Methods;Modality;Monitor;mortality;Observational Study;Operative Surgical Procedures;Pathologic;Patients;Periodicity;Physiological;Population Statistics;pressure;Prevalence;Process;profiles in patients;Property;prospective;Recommendation;Recording of previous events;Research Project Grants;Retrospective cohort study;Retrospective Studies;Risk;risk prediction;Risk Reduction;ROC Curve;Rupture;Ruptured Aneurysm;screening;sensor;shear stress;Site;Skin;standard of care;Structure;surgery outcome;surveillance strategy;System;theories;Thoracic aorta;Time;Tissues;training data;wearable device;wearable sensor technology;Work;X-Ray Computed Tomography

PROJECT_TITLE: Measurement of ab-initio physiomarker using wearable sensors to predict aneurysm growth and formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Racial and ethnic (R&E) minoritized persons with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) often receive poorer quality care than White patients, including lower rates of advance directives, reduced receipt of anti-dementia medications, and increased end-of-life hospitalizations. Although governmental and institutional policies influence R&E diversity in medical education/training and work environments, little is known about how R&E diversity in medical education, residency training, and health system leadership affect R&E disparities in AD/ADRD care. Applying innovative quasi-experimental methods to the nationally-representative comprehensive data on patients, physicians, medical schools, residency programs, and health systems, the proposed study will elucidate the effect of R&E diversity and cultural competency of medical school student bodies, residency programs, and health system boards on R&E disparities in AD/ADRD care and outcomes, providing new, policy-relevant information to develop interventions that could effectively eliminate such disparities.

PI_NAMEs: TSUGAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acute;advanced directive;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;American Hospital Association;American Medical Association;Association of American Medical Colleges;Awareness;Behavior;care providers;care systems;Caregivers;Caring;Categories;Characteristics;County;cultural competence;Cultural Sensitivity;Data;Data Set;Databases;Dementia;dementia care;Disparity;disparity elimination;disparity reduction;Distress;econometrics;end of life;Equity;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;experience;health assessment;Health Personnel;Health system;Healthcare;Home;Hospitalization;Hospitals;improved;innovation;Institutional Policy;Instruction;instrument;Intervention;Knowledge;Leadership;Link;Long-Term Care;Medical;Medical Education;medical schools;Medical Students;Medicare claim;Methods;Minority;minority patient;minority student;Modeling;nonEnglish language;Outcome;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;Positioning Attribute;Process;professional atmosphere;programs;Quality of Care;Quality of life;Quasi-experiment;Race;racial disparity;racial diversity;racial minority;racial minority population;Research;Research Personnel;Residencies;Rotation;safety net;Sampling;Schools;Spanish;Statistical Methods;Surveys;Testing;Training;Training and Education

PROJECT_TITLE: The effect of medical school, residency program, and health system board diversities on racial and ethnic disparities in AD/ADRD care.


NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

PHR: RESEARCH NARRATIVE Post-surgical pain causes significant suffering to patients, but physicians still lack an effective non-opioid therapy. We aim to determine if human birth tissue products can be developed to treat post-surgical pain and unravel a dual mode of drug action: reducing excitability of primary sensory neurons and hastening wound healing. We envision that these complementary drug actions may lead to a lasting pain relief and a potential “cure” for post-surgical pain.

PI_NAMEs: GUAN, YUN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acceleration;Accidents;Acute;Adverse effects;Afferent Neurons;allodynia;Anti-Inflammatory Agents;Antiinflammatory Effect;Attenuated;Birth;Bullous Keratopathy;Cells;Cessation of life;Cicatrix;Clinical;Complex;Cornea;cytokine;Cytoskeleton;Development;Diameter;drug action;Eye diseases;Flow Cytometry;Goals;Human;Hyaluronic Acid;Immune;Immune Targeting;in vivo;indium arsenide;Inflammation;Inflammatory;Injections;Injury;Interleukin-10;Ion Channel;Laws;Macrophage;manufacture;mast cell;Mediating;medical schools;Membrane;mouse model;Mus;Muscle;neuronal excitability;Neurons;Nociception;non-opioid analgesic;novel;Opioid;Opioid Analgesics;Overdose;overdose death;Pain;pain inhibition;Pain management;pain reduction;pain relief;Particulate;Patients;Persistent pain;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physicians;Postoperative Pain;pre-clinical;Principal Investigator;programs;PTX3 protein;public health emergency;Radiation;Rattus;receptor;recruit;regenerative healing;Regenerative wound healing;Research Personnel;response;Risk;Rodent Model;Safety;side effect;Skin;skin wound;Spinal Ganglia;Surgical incisions;Testing;Therapeutic Effect;Thick;Tissues;TRPV1 gene;Umbilical cord structure;Universities;voltage;wound;wound environment;wound healing

PROJECT_TITLE: Birth Tissue Products for Non-opioid Treatment of Post-surgical Pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative This project will establish research and mentoring infrastructure to create and sustain a diverse, equitable, inclusive, and accessible aging research community in social and behavioral sciences to advance research on Alzheimer's disease and related dementias. The team-based research community will support early-career faculty members from diverse background to conduct pilot studies to enhance the well-being of adults aging with or at risk for Alzheimer's Disease Related Dementia and those who care for them.

PI_NAMEs: BHATT, TANVI ;MURAMATSU, NAOKO  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Asian;Asian Americans;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;Black race;care providers;career;Caring;Chicago;Cities;Classification;Cognitive aging;cognitive function;Collaborations;Communication;Communities;community engaged research;Community Healthcare;community partners;Consultations;Country;Development;disability;Disability status;early-career faculty;Economics;Education;education research;empowerment;Equity;equity, diversity, and inclusion;ethnic identity;Ethnic Origin;Faculty;family support;Fostering;Funding;Gender Identity;Health;health equity;Health equity research;health inequalities;Health Promotion;Healthcare Systems;Hispanic-serving Institution;Home;Illinois;Immigration;Impaired cognition;Inequity;Infrastructure;innovation;Institution;intersectionality;Intervention;intervention effect;Language;Latino;Leadership;lens;Life Cycle Stages;member;Mentors;Mentorship;Methodology;Midwestern United States;Minority;Minority Groups;multilevel analysis;Native Americans;novel;older adult;older driver;Pacific Island Americans;Personal Satisfaction;Physical activity;Pilot Projects;Policies;population based;population health;Population Sciences;prevent;pro-aging;Process;programs;psychologic;Race;racial identity;Recording of previous events;recruit;Research;Research Infrastructure;Research Support;Resources;Scientist;Services;sexual identity;social;social culture;social science research;Social Sciences;Socioeconomic Status;Stress;Stress and Coping;synergism;Targeted Research;Technology;Testing;tool;Training;training opportunity;Translations;Underrepresented Minority;Universities;Variant;Work

PROJECT_TITLE: Center for Health Equity in Cognitive Aging - Joining Population Science and Health Promotion (CHECA)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: MURAMATSU, NAOKO  (contact)

PROJECT_TERMS: Adult;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavioral;behavioral and social science;career;caregiving;Caring;Chicago;Clinical;Clinical Trials Design;Cognitive aging;Collaborations;Committee Members;Communication;Communities;Community Health;Community Practice;Coordination and Collaboration;Data;design;Development;Doctor of Philosophy;Enrollment;Ensure;Evaluation;evidence base;experience;Goals;Government Agencies;health disparity;health equity;health inequalities;Health Policy;Health Promotion;Health Sciences;Health Status;Illinois;improved;Infrastructure;infrastructure development;Institution;interest;Leadership;meetings;member;Mentors;Methods;Midwestern United States;Minority;Mission;Monitor;Nonprofit Organizations;older adult;operation;Outcome;outreach;Pilot Projects;Policies;population health;Population Sciences;Positioning Attribute;Private Sector;product development;programs;Progress Reports;Public Health Informatics;Reduce health disparities;Reporting;Research;Research Personnel;Research Support;Risk Reduction;Scientific Advances and Accomplishments;Scientist;social;Social Conditions;social science research;Strategic vision;Testing;Translational Research;Translations;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BERBAUM, MICHAEL L. (contact)

PROJECT_TERMS: Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Awareness;Behavior Therapy;behavioral and social science;Behavioral Sciences;career;Caring;Cognition;Cognitive aging;Collaborations;Collection;Communication;Communities;Data;Data Analyses;Data Collection;data management;Dementia;design;Development;Disparate;ethnic disparity;Evaluation;Evaluation Research;experience;Faculty;Feasibility Studies;Fostering;Goals;Head;Health;health equity;Health Promotion;Impaired cognition;Individual;Infrastructure;innovation;Intervention;Knowledge;Lead;Leadership;Life;Life Cycle Stages;Longitudinal Surveys;Measurement;member;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;Observational Study;older adult;Paper;Pilot Projects;population health;Population Sciences;posters;programs;Questionnaires;racial disparity;Research;Research Design;Research Personnel;Research Project Grants;Sample Size;Science;Scientific Advances and Accomplishments;Scientist;skills;social science research;Social Sciences;sound;Statistical Data Interpretation;Targeted Research;therapy development;Training;Training and Infrastructure;United States National Institutes of Health;Work;Writing