ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Deep learning models have been deployed in an increasing number of edge and mobile devices to provide diagnosis. However, all of these techniques rely on visual assistance of the cameras and can lead to different levels of Fairness concerns. This project aims to address this new technology inequity by developing a distributed, federated on-device machine learning framework to learn from diversified data source with minimal human supervision while preserving privacy.

PI_NAMEs: HU, JINGTONG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Admission activity;Age;Algorithms;Architecture;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Asian;Awareness;Case Study;Cellular Phone;Code;Communities;Computer software;Darkness;Data;Data Collection;Data Set;Data Sources;Databases;deep learning model;Dermatology;Detection;Devices;Diagnosis;Disparity;Emotions;Ensure;Equity;Exhibits;Face;federated learning;Gender;Goals;handheld mobile device;health care disparity;Healthcare;Heterogeneity;Hispanic;Human;Image;improved;Inequality;Inequity;innovation;Interdisciplinary Study;Label;Lead;Learning;learning progression;Life;Light;Machine Learning;machine learning framework;malignant neoplasm of eye;marginalized community;Medical;men;mHealth;Minority;Minority Groups;mobile application;Modeling;Monitor;neural;neural network;new technology;Outcome;outcome disparities;Patients;Performance;Persons;Population;Population Heterogeneity;privacy preservation;Race;racial disparity;Reporting;Research;Safety;sex;Skin;skin color;socioeconomic disparity;Socioeconomic Status;socioeconomics;Supervision;Techniques;Underrepresented Populations;Visual;Woman

PROJECT_TITLE: Achieve Fairness in AI-Assisted Mobile Healthcare Apps through Unsupervised Federated Learning

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Gammaherpesviruses permanently infect most of the adult population worldwide and are associated with B cell lymphomas. The risk factors that predispose towards the development of gammaherpesvirus-driven lymphomas are not well defined and there are no vaccines or curative antivirals available for the infection. This grant application focuses on a viral protein that is shared by all gammaherpesviruses and aims to define how this viral protein supports chronic infection with the goal of generating new viral and host therapeutic targets.

PI_NAMEs: TARAKANOVA, VERA L. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Adult;African Burkitt's lymphoma;Animal Model;Anti-viral Agents;Applications Grants;B cell differentiation;B-Cell Lymphomas;B-Lymphocytes;Cell Compartmentation;cell type;Chronic;chronic infection;Cyclic AMP-Dependent Protein Kinases;Development;Ensure;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;gammaherpesvirus;Gene Expression;Genetic;Goals;Heart;Herpesviridae;Herpesviridae Infections;Hodgkin Disease;Human;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Infection;Interferons;Interleukin-10;large cell Diffuse non-Hodgkin's lymphoma;latent gene expression;latent infection;Lead;Life Cycle Stages;Link;Lymphoma;Lymphomagenesis;Lytic;Macrophage;Malignant Neoplasms;Memory B-Lymphocyte;Modeling;Molecular;monocyte;mouse model;Mus;Myelogenous;Natural Immunity;new therapeutic target;novel;pathogen;Pathogenesis;Pathway interactions;Phenotype;Phosphotransferases;Physiological;Population;Predisposing Factor;Prevention;Proliferating;protein function;Protein Kinase;Protein Kinase Interaction;Publishing;Reaction;response;Risk Factors;Rodent;Role;Signal Pathway;Signal Transduction;Species Specificity;STAT1 gene;Structure of germinal center of lymph node;T cell response;Testing;therapeutic target;Transgenic Animals;Vaccines;Viral;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virus;Virus Latency

PROJECT_TITLE: Gammaherpesvirus protein kinase: a master manipulator of the host during chronic infection.

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UCLA Dental Specialty PhD Program (UCLA DSPP) is a research career development program that supports a small, select group of early-career dentists in their pursuit of dual training in a dental clinical specialty and rigorous scientific research leading to a specialty certificate and PhD degree. UCLA DSPP Scholars are expected to be critical thinkers, effective communicators, and compassionate, skilled clinicians capable of delivering patient-centered care in a rapidly evolving health care environment and to be leaders in solving patient-oriented challenges facing the current and future of dentistry.

PI_NAMEs: KAPILA, YVONNE L (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;California;career;career development;Clinical;college;Complex;conflict resolution;Dental;Dental Education;Dental Research;Dental Schools;Dental Specialties;Dentistry;Dentists;Doctor of Philosophy;Ensure;Environment;Equity;evidence base;experience;Faculty;Female;Funding;Future;Goals;graduate medical education;Healthcare;Learning;Los Angeles;marginalized community;medical specialties;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Monitor;Oral health;patient oriented;Patient-Centered Care;pedagogy;Postdoctoral Fellow;Productivity;programs;recruit;Research;Research Personnel;Research Training;Residencies;Scholars Program;School Dentistry;Scientist;skills;Texas;Training;Training Programs;Universities

PROJECT_TITLE: UCLA Dental Specialty PhD Program


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: In this proposal we will investigate the roles for synaptic calcium channels in the organization and function of the photoreceptor synapse. Results of this work will promote the development of new approaches to treat injuries and diseases of the retina that cause blindness by disrupting synaptic communication.

PI_NAMEs: LEE, AMY  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Animal Model;Architecture;Binding;biophysical properties;Blindness;C-terminal;Calcium Channel;Calmodulin;Cell Adhesion Molecules;Cell Transplantation;Clinical;Communication;Compensation;Cone;Data;Development;Disease;Electrophysiology (science);Genes;Glutamates;Goals;Human;Image;In Vitro;in vivo;inducible gene expression;Injury;innovation;insight;Ions;Knock-in Mouse;Knowledge;Lighting;Mediating;Molecular;molecular assembly/self assembly;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;Neurites;Neurophysiology - biologic function;Night Blindness;novel strategies;Pathologic;Pathway interactions;Photoreceptors;Point Mutation;Positioning Attribute;postsynaptic;presynaptic;Process;Property;Proteins;Recombinants;Research;Resistance;Retina;Retinal Cone;Retinal Diseases;Retinal Photoreceptors;ribbon synapse;RNA Splicing;Rod;Role;scaffold;sensor;Shapes;sight restoration;Signal Pathway;Signal Transduction;Source;Structure;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Techniques;Testing;Transfection;transmission process;transplantation therapy;Variant;Vertebrate Photoreceptors;Vision;Visual impairment;voltage;Work

PROJECT_TITLE: Calcium channels in retinal photoreceptors

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Immunization;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE  Herpes simplex virus (HSV) causes cold sores, genital sores, ocular infections, and encephalitis; can cause permanent ocular and brain damage and death in newborns; and is associated with neurodegeneration. This work will test the ability of maternal immunization and vector-delivered antibodies to protect newborns and adults from HSV-induced corneal diseases, behavioral pathologies, and neurodegeneration in a mouse model. We will also test the role of the autophagy pathway in the genesis of HSV-induced corneal disease, and whether autophagy- modulating agents can prevent or reduce ocular damage and other sequelae of HSV infection.

PI_NAMEs: LEIB, DAVID A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;acute infection;Acyclovir;adaptive immunity;adeno-associated viral vector;Adult;Alzheimer's Disease;American;Animal Model;Anterior;Anti-viral Agents;Antibodies;Anxiety;Area;Autophagocytosis;Bacteremia;Behavior;Behavioral;Birth;Blepharitis;Blindness;Brain Death;Brain Injuries;Central Nervous System Diseases;Clinical;Clinical Research;clinically significant;Communities;Congenital herpes simplex;congenital infection;Conjunctivitis;Cornea;Corneal Diseases;Data;Dependovirus;Development;Diagnosis;Disease;Economic Burden;Emotional;Encephalitis;Epithelium;Exposure to;Eye diseases;Eye Infections;Female;fetal;Frequencies;Funding;Gene Expression;Genes;genital infection;Genitalia;Goals;Health;Herpes Labialis;Herpes Simplex Infections;Herpes stromal keratitis;Herpesviridae;Herpesvirus 1;Herpetic Keratitis;Human;Human Herpesvirus 2;Human Milk;human model;Immune;Immunize;improved;Incidence;Individual;Infant;Infection;Integration Host Factors;Intervention;Keratitis;latent infection;Learning;Life Cycle Stages;long-term sequelae;Maternal antibody;maternal vaccination;Maternally-Acquired Immunity;Mediating;member;Memory;Morbidity - disease rate;mortality;Mothers;mouse model;Mouth Diseases;mucosal site;Mus;Natural Immunity;Neonatal;neonatal health;neonatal immune system;neonatal infection;Neonatal Mortality;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurodevelopmental Disability;Neurologic;Neurons;neurosensory;neurotropic;Newborn Infant;novel;novel therapeutic intervention;offspring;Outcome;Pathogenesis;Pathology;Pathway interactions;Pattern;Peripheral;Phase;Placenta;Population;postnatal;postnatal period;preclinical study;prevent;Prevention;Prevention approach;prophylactic;prototype;Recrudescences;Recurrence;Reporting;Research;Resistance;Risk;Role;Seizures;Sepsis;Seroprevalences;Simplexvirus;Site;Skin;skin disorder;Spastic Tetraplegia;standard of care;Strategic Planning;Testing;Therapeutic;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Tissues;translational study;vaccine candidate;Vaccines;vector;Vertical Transmission;Viral;Viral Encephalitis;Viral Genes;Viral Load result;Viral Pathogenesis;viral transmission;Virus;Virus Diseases;Virus Latency;Virus Replication;Vision;Vision Tests;Visual System;Vulnerable Populations;Work

PROJECT_TITLE: Viral and Host Factors in Herpetic Diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Project Narrative In addition to its central purpose of human reproduction, pregnancy has a profound impact on the physiology and development of a woman's breast tissue. Importantly, the age of first pregnancy has a strong influence on milk supply and predisposition to breast cancer initiation, across several mammalian species. Thus, a major open question is what are the underlying mechanisms that link age of pregnancy to modify breast function? In this proposal we will use mouse and human model systems to address outstanding questions about the evolution and molecular adaptation of breast cells to aging and its effects on controlling development, gene expression and cancer initiation.

PI_NAMEs: DOS SANTOS, CAMILA  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adaptive Immune System;Address;Age;age effect;age related;Age Years;aged;Aging;aging related;Biological Models;Biology;Breast;Breast Epithelial Cells;c-myc Genes;Cancer Control;cancer initiation;Cell Differentiation process;Cells;Cytotoxic T-Lymphocytes;Data;Development;DNA Methylation;Environment;Epigenetic Process;epigenome;epigenomics;Event;Evolution;experience;Female;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Health;Homeostasis;Hormones;Human;human model;Immune;Immune system;improved;insight;Investigation;Malignant - descriptor;Malignant Breast Neoplasm;Mammals;mammary;mammary epithelium;Mammary gland;Mammary Gland Parenchyma;Mammary Neoplasms;milk production;milk supply;Modality;Modification;Molecular;mouse model;Mus;novel;old mice;Oncogenes;Organism;Organoids;Outcome;Output;overexpression;Phenotype;Physiology;Population;post pregnancy;Predisposition;Pregnancy;Pregnancy Maintenance;pregnant;Program Development;Publishing;Reporting;Reproduction;Research;response;Role;Signal Transduction;Time;Tissues;transcriptomics;tumor-immune system interactions;tumorigenesis;Variant;Woman;Work

PROJECT_TITLE: Defining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiation


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Redox biology and medicine, the theme of this predoctoral training program at Wake Forest University for which funding is requested, denotes the specialized chemistry of oxidation and reduction occurring in biological systems which orchestrates metabolism and signaling to elicit specific cellular responses. Redox mechanisms support well-being and are also involved in the development and progression of many diseases. The goal of this training program is to bring scientists from diverse backgrounds and diverse programs such as chemistry, physics and molecular medicine together to train in the performance of interdisciplinary redox research to improve human health.

PI_NAMEs: FURDUI, CRISTINA MARIA;POOLE, LESLIE B (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Redox Biology and Medicine Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project is aimed at examining neural circuit mechanisms and therapeutic interventions in multiple animal models relevant to schizophrenia. To achieve this vision, basic characterization of frontal and thalamic circuitry is necessary, which will be done at the molecular, physiological and behavioral levels.

PI_NAMEs: FENG, GUOPING ;HALASSA, MICHAEL M (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Affect;Animal Model;Animals;attentional control;Basic Science;Behavior;Behavioral;behavioral phenotyping;cell type;Cells;Cognition;Cognitive deficits;cognitive enhancement;cognitive task;Consciousness Disorders;Data;Data Analyses;Decision Making;Delusions;Development;Disease;Dissection;effective therapy;Electrodes;Epilepsy;Essential Tremor;Exhibits;exome sequencing;Foundations;Functional disorder;Future;Generations;Genes;Genetic;Gilles de la Tourette syndrome;GRIA3 gene;Hallucinations;Human;Impaired cognition;Interneurons;Intervention;Knock-in Mouse;Link;loss of function;Meta-Analysis;Methodology;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;network dysfunction;neural circuit;neuroimaging;Neurons;novel;Opsin;optogenetics;Pathology;Patients;Pattern;Phenocopy;Physiological;Population;Prefrontal Cortex;Public Health;Publishing;rare variant;Regulation;Resistance;Schizophrenia;schizophrenia risk;Structure;success;Symptoms;Technology;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;Therapeutic Intervention;tool;transcriptomics;treatment strategy;Validation;Variant;Vision

PROJECT_TITLE: Genetic and Functional dissection of frontal thalamocortical circuitry

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Climate-Related Exposures and Conditions;Skin Cancer

ORG_CITY: MADISON

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE:  The goal of this study is to determine the role and therapeutic significance of polo-like kinase 4 (PLK4), an important regulator of cell division, alone and in combination with other promising target-based agents, for the management of melanoma, which is one of the most dangerous form of skin cancers. Our study may ultimately lead to the development of novel therapeutic strategies for clinical management of melanoma.

PI_NAMEs: AHMAD, NIHAL  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adverse effects;Biogenesis;BRAF gene;Breslow Thickness;Cadherins;cancer cell;carcinogenesis;CDK4 gene;Cell Cycle Progression;Cell division;Cell Line;cell motility;Centrioles;Centrosome;Clinical;Clinical Management;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Cyclin D1;Dangerousness;Data;Development;Diagnostic;Disease Outcome;driver mutation;druggable target;epidemiologic data;epithelial to mesenchymal transition;Epithelium;experimental study;Failure;Fibronectins;Genetic Transcription;Genetically Engineered Mouse;genomic data;Genomic Instability;Goals;Human;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;inhibitor;Investigation;knock-down;Knock-out;Lesion;Link;liquid crystal polymer;LOX gene;Malignant - descriptor;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;melanocyte;Melanocytic nevus;Melanoma;Melanoma Cell;Melanoma Tumor;Mesenchymal;Metastatic Melanoma;Modality;Modeling;mortality;mouse model;Mutation;Neoplasm Metastasis;Neoplasms;New Drug Approvals;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;PET/CT scan;Phosphotransferases;PI3K/AKT;Play;PLK1 gene;Primary Neoplasm;prognostic;prognostic value;Protein-Serine-Threonine Kinases;Proteins;Publishing;Ras/Raf;Recurrence;Research;Resistance;Resistance development;response;Role;Sampling;Serine;Signal Transduction;Skin Cancer;small molecule;Snails;Specimen;Staging;System;Therapeutic;Time;Tissue Microarray;Transgenic Mice;tumor progression;Ultraviolet Rays;UV induced;Vimentin;X-Ray Computed Tomography;Xenograft procedure

PROJECT_TITLE: Functional and Therapeutic Significance of PLK4 in Melanoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Estrogen;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE  While effective at suppressing HIV replication, current antiretroviral treatments fail to eliminate the latent HIV reservoir, the vast majority of which persists within the gut. We propose to conduct an in-depth analysis of the gut reservoir in virally-suppressed men and women living with HIV, to test potent next-generation latency reversal agents for their ability to "shock" these cells out of latency, and to manipulate signaling pathways prominent in the gut to enhance immune-mediated clearance of reactivated gut cells. These studies will not only establish a much-needed better understanding of the gut reservoir and the mechanisms that facilitate their long-term persistence, but further tests the ability of promising and novel therapeutic approaches to eradicate this important reservoir.

PI_NAMEs: ARCHIN, NANCIE MARIE;ROAN, NADIA R (contact);SHEIKH, SHEHZAD Z.

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Adhesions;Adjuvant;Affect;Animal Model;antagonist;Antibodies;antiretroviral therapy;attenuation;Autologous;Autopsy;Back;Bioinformatics;Biological Markers;biological sex;Biopsy;Blood;Blood specimen;Bromodomains and extra-terminal domain inhibitor;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;Chimera organism;chimeric antigen receptor T cells;Chronic;Clinical;Clonal Expansion;Clonality;cohort;Colon;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;deep sequencing;design;Development;efficacy evaluation;engineered T cells;Engineering;Environment;ESR1 gene;Estrogens;Female;Frequencies;Gene Expression;Genetic Transcription;Gifts;Growth Factor;gut homeostasis;Histone Deacetylase Inhibitor;HIV;HIV Antigens;HIV Infections;hormone therapy;humanized mouse;ileum;Immune;Immunosuppression;improved;in vivo;Individual;inhibitor;Knowledge;latent HIV reservoir;Maintenance;male;Mediating;men;Metabolism;Methods;Mitogens;Modeling;Molecular;Morphogenesis;multiple omics;Myeloid Cells;next generation;NF-kappa B;nonhuman primate;novel;novel marker;novel therapeutic intervention;Pathway interactions;Patients;peripheral blood;Persons;Phenotype;Play;Postmenopause;Premenopause;Property;Proteins;Proteome;Proviruses;purge;receptor;Recording of previous events;recruit;Resistance;response;Role;sex;Shock;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;SIV;Specimen;Surface;T cell response;T-Lymphocyte;Technology;Testing;Tissues;tool;Transcript;transcriptome;Transforming Growth Factors;treatment response;Viral;Viral Load result;Viral reservoir;Virus Diseases;Woman

PROJECT_TITLE: Multiomics characterization, induction, and elimination of the HIV gut reservoir


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurofibromatosis;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with most common manifestation being the development of bilateral schwannomas of the 8th cranial nerve (Vestibular schwannoma). Although our understanding of the molecular mechanisms underlying NF2 has significantly improved over the past 2 decades, effective therapies remain lacking for this disease and there is an urgent need to develop therapeutic options for patients. Our goals in this proposal are to employ new screening technologies to identify and develop small-molecule inhibitors into leads for therapeutic development for NF2.

PI_NAMEs: KISSIL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: 3-Dimensional;Acoustic Neuroma;Affinity;analog;autosome;Benchmarking;bevacizumab;Bilateral;Biological Assay;Cell Culture Techniques;cell growth;Cell Survival;Cells;Characteristics;Chemicals;Collection;Cranial Nerves;cytotoxic;Development;Disease;drug development;drug discovery;effective therapy;Environment;Ependymoma;Exclusion;experience;Exposure to;Funding;gain of function;Generations;Goals;Growth;Human;improved;in vivo;in vivo Model;Inherited;innovation;Intervention;Knowledge;Lead;Libraries;Ligands;loss of function;meningioma;Methods;Molecular;monolayer;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;Nervous System;Nervous System Disorder;Neurilemmoma;Neurofibromatosis 2;Neurofibromin 2;new therapeutic target;Null Lymphocytes;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phenotype;Physiological;preclinical development;programs;Proteins;Proteome;Proteomics;Radiation therapy;Regulation;Research;Schwann Cells;screening;Signal Pathway;small molecule;small molecule inhibitor;small molecule libraries;spheroids;stem;success;Symptoms;Technology;Therapeutic;Therapeutic Agents;therapeutic development;tumor;Tumor Suppressor Genes;two-dimensional;Validation

PROJECT_TITLE: Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Emerging evidence supports the association between periodontitis and Alzheimer’s disease (AD); however, the underlying mechanisms remain unknown. The proposed studies will explore the effect of periodontitis on microglia priming and activation, and the involvement of complement component C1q in AD development in the presence of periodontitis.

PI_NAMEs: ZHANG, PING  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Acceleration;Adult;Affect;age related;Alveolar Bone Loss;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;behavioral impairment;Brain;Cells;Central Nervous System Diseases;Chronic;chronic infection;Classical Complement Pathway;Clinical;Communicable Diseases;Complement;Complement 1q;Complement Activation;complement system;cytokine;Dementia;Development;Disease;Disease Progression;effectiveness evaluation;Epidemiology;Etiology;Gene Expression Profile;glial activation;Grant;Human;Immune;immunoregulation;Impaired cognition;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Invaded;Knowledge;Ligature;Link;Literature;Mediating;microbial;Microglia;Modeling;Mus;mutant;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;Oral;oral infection;Osteitis;Pathogenicity;Peptide Initiation Factors;Periodontal Diseases;Periodontal Infection;Periodontitis;periodontopathogen;Play;Porphyromonas gingivalis;Predisposition;Prevalence;preventive intervention;Process;Production;Reporting;Research;response;Role;Severities;Severity of illness;Source;Stimulus;Synapses;Testing;Time;Tissues;Tooth structure;Training;Wild Type Mouse

PROJECT_TITLE: IMPORTANCE OF PERIODONTITIS IN THE INNATE IMMUNE REGULATION OF ALZHEIMER'S DISEASE

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BURLINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative The Vermont Genetics Network INBRE builds biomedical research infrastructure including core facilities that enable faculty in the network to become more competitive for extramural funds and allows them to develop their innovative biomedical research plans, thereby promoting discoveries through basic and applied research that will impact human health care. The INBRE also inspires and prepares undergraduates for a variety of biomedical careers there by increasing the biomedical and health care workforce size and diversity for Vermont and the nation.

PI_NAMEs: FRANCKLYN, CHRISTOPHER S (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Advisory Committees;Applied Research;Award;Basic Science;Behavior;Bioinformatics;Biomedical Research;career;Career Choice;Categories;Centers of Research Excellence;Collaborations;college;Communication;community college;Core Facility;course module;cyber infrastructure;Data Analyses;data management;Development;Education;Educational Curriculum;Enrollment;Evaluation;experience;Extramural Activities;Faculty;faculty research;First Generation College Students;Fostering;Funding;Genetic;Goals;Grant;Grant Review;Health;Healthcare;Human;Human Resources;innovation;Institution;Internships;Leadership;meetings;member;Mentors;Mission;Network Infrastructure;organizational structure;outreach;Population;Process;Productivity;Program Research Project Grants;programs;Proteomics;Protocols documentation;Publications;Publishing;Research;Research Infrastructure;Research Training;Resource Sharing;Resources;Rural;science education;Services;STEM field;student training;Students;success;symposium;tool;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Universities;Vermont;Woman;Work

PROJECT_TITLE: Vermont Genetics Network - Vermont INBRE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;American Association for the Advancement of Science;Award;Bioinformatics;Biomedical Research;Budgets;career;Centers of Research Excellence;Collaborations;Communication;conflict resolution;Development;Education;Ensure;Evaluation;Event;experience;Extramural Activities;Faculty;faculty mentor;First Generation College Students;formative assessment;Funding;Future;Genetic;Goals;Grant;Guidelines;human subject;improved;Infrastructure;Institution;interest;Lead;Leadership;Longitudinal Surveys;meetings;member;Mentors;Mission;Monitor;National Institute of General Medical Sciences;operation;Participant;Policies;Principal Investigator;Procedures;Process;Program Development;programs;Proteomics;Publications;Recommendation;recruit;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Secure;Services;STEM field;Students;success;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Vermont;Vertebrates;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DRAGON, JULIE  (contact)

PROJECT_TERMS: Access to Information;Advisory Committees;American Association for the Advancement of Science;Applications Grants;Award;Bioinformatics;bioinformatics infrastructure;bioinformatics network;bioinformatics resource;Biological;Biological Sciences;biomarker discovery;Biomedical Research;biomedical resource;Biometry;cancer biomarkers;Collaborations;Computer Analysis;Computer software;computerized tools;Computers;computing resources;Consultations;Core Facility;cost effective;Coupled;cyber infrastructure;Data;Data Analyses;Data Set;Data Storage and Retrieval;Databases;Dedications;design;Development;Disease;DNA;Education;Educational Curriculum;Ensure;experience;Experimental Designs;Extramural Activities;Faculty;faculty research;Funding;Genetic;genome sequencing;Genomics;Goals;Health;Home;Human;Human Resources;Informatics;Information Technology;Infrastructure;innovation;Institution;instrument;internal control;investigator training;large datasets;Letters;member;Methods;Mission;Modernization;next generation;Performance;Play;power analysis;Preparation;programs;Proteins;Proteomics;Publications;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA;Role;Scientist;Services;Solid;Students;success;Techniques;tool;Training;Training Activity;Training and Education;transcriptomics;undergraduate student;Universities;Vermont;whole genome;Work

PROJECT_TITLE: Bioinformatics Core


PI_NAMEs: LAM, YING WAI  (contact)

PROJECT_TERMS: Area;Bioinformatics;bioinformatics network;Biomedical Research;Businesses;Career Choice;Client;Collaborations;Communities;Consult;course module;Custom;Data;Data Analyses;Development;Education;Education and Outreach;Ensure;equipment acquisition;experience;Experimental Designs;Extramural Activities;Faculty;faculty research;faculty support;Fostering;Funding;Future;Genetic;Goals;Grant;hands on research;Home;innovation;Institution;laboratory curriculum;Learning;lectures;Manuscripts;Mass Spectrum Analysis;Methodology;Mission;operation;outreach;Preparation;Price;Procedures;Productivity;programs;Protein Analysis;Proteome;Proteomics;Publications;Research;Research Activity;Research Personnel;Research Training;Sampling;science education;Services;skills;student participation;student training;Students;Technology;Time;Training and Education;undergraduate student;Universities;Vermont;Work

PROJECT_TITLE: Proteomics Core


PROJECT_TERMS: Academia;Applications Grants;Award;Biomedical Research;career;Collaborations;college;Core Facility;Development;Development Plans;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Event;experience;Exposure to;Extramural Activities;Faculty;faculty mentor;faculty research;Funding;Genetic;Goals;Grant;Growth and Development function;improved;Individual;Industrialization;Infrastructure;Institution;Internships;Journals;Link;Manuscripts;Mentors;Mission;Monitor;novel;outreach;Peer Review;Productivity;programs;Publications;Publishing;Research;research and development;Research Project Grants;Research Support;scaffold;Scholars Program;Science;Students;success;summer research;support network;Technical Expertise;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Vermont;Work;Writing

PROJECT_TITLE: Professional Development & Education Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: There is a need to find new and effective treatment regimens against inflammatory bowel disease (IBD). We will identify small molecule inhibitors of a novel target against IBD. This project may lead to a new treatment for the disease.

PI_NAMEs: SUBAUSTE, CARLOS S (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Affinity;analog;Animal Model;Anti-CD40;Antibodies;Binding;Biological Assay;Blocking Antibodies;Blood Platelets;Caco-2 Cells;Cell Adhesion Molecules;Cells;chemokine;Clinical Trials;Colitis;Collaborations;crosslink;cytokine;Dendritic Cells;design;dextran sulfate sodium induced colitis;Disease;Docking;Dose;effective therapy;Endothelial Cells;Endothelium;Epithelial Cells;experience;Gastrointestinal tract structure;Genetic;gut inflammation;high throughput screening;Histopathology;Human;Ileitis;Immune response;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Intercellular adhesion molecule 1;Intestinal Diseases;Intestines;Knowledge;Lead;lead optimization;Leukocytes;Luciferases;lymphotoxin beta receptor;Macrophage;MAPK1 gene;MAPK11 gene;MAPK8 gene;Mediating;Medicine;Microsomes;Modeling;Monoclonal Antibodies;monocyte;mouse model;murine colitis;Mus;neutrophil;novel;novel strategies;novel therapeutic intervention;Opportunistic Infections;opportunistic pathogen;Oral;OX40;Pathway interactions;Patients;Permeability;Phosphorylation;Predisposition;prevent;programs;Property;Receptor Signaling;recruit;Reporter;Resistance;response;Risk;RPS6KA5 gene;Series;side effect;Signal Transduction;small molecule;small molecule inhibitor;Solubility;Structure-Activity Relationship;System;T-Lymphocyte;Testing;Therapeutic;Thromboembolism;Thrombosis;TNF receptor-associated factor 3;TNFRSF1A gene;TNFRSF5 gene;TNFRSF8 gene;TNFSF5 gene;TRADD gene;TRAF2 gene;Transgenic Mice;Treatment Protocols;treatment response;Tumor Necrosis Factor Receptor;Up-Regulation;Work

PROJECT_TITLE: Small molecule inhibitor of CD40 signaling for the control of inflammatory bowel disease


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Dietary Supplements;Mental Health;Neurosciences;Nutrition;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The environmental causes of cerebral cortical defects that can be central to neurodevelopmental disorders remain poorly understood. Our research will uncover how different amounts of folic acid intake during pregnancy possibly in conjunction with vitamin B12 deficiency can alter brain development and potentially contribute to neurodevelopmental conditions.

PI_NAMEs: GREEN, RALPH ;ZARBALIS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adolescent;Animal Model;Animals;Anxiety Disorders;anxiety-related behavior;Apoptosis;Apoptotic;autism spectrum disorder;behavior test;Behavioral;Biochemical;Biological Assay;bisulfite sequencing;Blood;Blood specimen;Brain;brain size;Carbon;Cereals;Cerebral cortex;Cerebrum;Child;childhood epilepsy;Cognition Disorders;Compensation;Conceptions;Consumption;Defect;density;deprivation;Development;Diet;dietary;dietary supplements;DNA Methylation;Embryo;embryo tissue;Enzymes;epidemiology study;Exhibits;Exposure to;fetal;Folic Acid;Folic Acid Deficiency;folic acid supplementation;Fortification;Fortified Food;Generations;Genetic;Grain;Guidelines;Histologic;Homocysteine;Human;In Situ Nick-End Labeling;Incidence;Intake;Intellectual functioning disability;Interneurons;Investigation;Label;Learning;Leucovorin;Link;Liver;Malabsorption Syndromes;Measures;Memory;Metabolism;metabolomics;Methionine;Methylation;methylation pattern;Methylmalonic Acid;Micronutrients;Morphology;Mothers;multidisciplinary;Mus;Natural regeneration;neocortical;nerve stem cell;Neural Tube Defects;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuronal Migration Disorder;Neurons;Newborn Infant;novel;object recognition;offspring;Outcome;Pathologic;Pathway interactions;Pattern;Placenta;Plasma;Population;Pre-Clinical Model;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;Prevention strategy;programs;Proliferating;Public Health;Publishing;pup;Reaction;Reporting;Research;Risk;Risk Factors;Series;Serum Folate Level;Site;SLC19A1 gene;social deficits;Social Interaction;Source;stem cell population;Structural defect;Supplementation;Testing;Tetrahydrofolates;Tissues;trend;Umbilical Cord Blood;United States Food and Drug Administration;Variant;Vegan Diet;Vertebral column;Vitamin B 12;Vitamin B 12 Deficiency;whole genome;Work;young adult

PROJECT_TITLE: Folic Acid, B12, and Neurodevelopmental Risk

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PROJECT_TERMS: Address;Applications Grants;Area;Award;Biomedical Research;Budgets;Categories;Collaborations;Collection;college;Consultations;Data;design;Development;Development Plans;Education;Educational process of instructing;Educational workshop;Ensure;equipment acquisition;expectation;experience;Experimental Designs;Extramural Activities;Faculty;faculty mentor;faculty research;federal policy;follow-up;Fostering;Foundations;Funding;Funding Opportunities;Genetic;Goals;Grant;Grant Review;Guidelines;Heart;Human;improved;Individual;Institution;Length;Manuscripts;member;Mentors;Molecular Genetics;Pathway interactions;Physiology;Preparation;Process;Productivity;Program Research Project Grants;programs;Publications;Publishing;Qualifying;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Series;skills;Students;success;Technology;Time;Training;undergraduate research experience;undergraduate student;Vermont;Work;Writing

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Cost Effectiveness Research;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Overweight and obese women with gestational diabetes mellitus are at increased risk for perinatal complications. The proposed research is relevant to public health because it will yield high-quality, detailed evidence regarding maternal glycemic control and adverse pregnancy outcomes. A better understanding of the optimal glycemic targets will have an important positive impact on our understating of how to care for overweight and obese women with gestational diabetes mellitus.

PI_NAMEs: SCIFRES, CHRISTINA MARIE (contact);TUULI, METHODIUS GAMUO

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: adverse maternal outcomes;adverse pregnancy outcome;Birth Weight;Caring;Cesarean section;clinical practice;Clinical Trials;Clinical Trials Design;Continuous Glucose Monitor;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Diabetes Mellitus;Effectiveness;effectiveness evaluation;Fasting;Fetal Growth;Fetal Macrosomia;Frequencies;Gestational Age;Gestational Diabetes;Glucose;glycemic control;Health;High Prevalence;high risk;High Risk Woman;Hour;Hypertension;Hypoglycemia;improved;Incidence;incremental cost;Infant;Knowledge;maternal obesity;Measures;Medical center;Morbidity - disease rate;multidisciplinary;Neonatal;Neonatal Hypoglycemia;neonatal morbidity;neonatal outcome;Obesity;offspring;Outcome Study;Overweight;perinatal complications;perinatal outcomes;Perinatology;Pharmaceutical Preparations;Phototherapy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;Pregnancy Rate;Pregnant Women;Prevalence;prevent;Public Health;Quality-Adjusted Life Years;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;respiratory distress syndrome;Risk;Risk Reduction;Safety;safety and feasibility;safety assessment;standard care;Testing;Translating;Weight;Woman;women's outcomes;Work

PROJECT_TITLE: Intensive Glycemic Targets in Overweight and Obese Women with Gestational Diabetes Mellitus: A Multicenter Randomized Trial

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative The proposed research will study the mutual effect of amyloid-related brain injury and ischemic stroke on cerebrovascular recovery. Since dementia outcomes are a national health crisis, understanding the effects of elevated Aβ on vascular and neuronal dysfunction will provide insight into their synergistic effects on post-stroke recovery and cognitive decline. Elucidating the mechanism that drives dysfunction of the blood-brain barrier and neural progenitor cells may help us develop therapeutic strategies to reduce the burden of neurological disease in CAA, stroke, and even clinical Alzheimer’s Disease.

PI_NAMEs: COLBERT, OLIVIA MARLOWE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: abeta accumulation;Affect;age related;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Animals;Architecture;Autopsy;Basal Ganglia;behavior test;Bioenergetics;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;Brain;Brain Injuries;Brain region;brain tissue;Bromodeoxyuridine;burden of illness;Cell Separation;Cells;Cerebral Amyloid Angiopathy;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;chemokine;Clinical;clinical practice;clinically relevant;Coagulation Process;cognitive function;Communication;Complex;Cues;Dementia;Deposition;Diagnosis;Differentiation Antigens;Dyes;endothelial dysfunction;experimental study;Extravasation;Functional disorder;Future;gene complementation;Gene Expression;Genus Hippocampus;Health;Hippocampus;Hospitals;Hour;Human;Immunohistochemistry;Impaired cognition;Infarction;Inflammasome;Inflammatory;Inflammatory Response;insight;intercellular communication;Interruption;Ischemia;Ischemic Stroke;Learning;Measures;Mediating;Medical;Medicine;memory process;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Monitor;Motor;mouse model;Mus;nerve stem cell;Nervous System Disorder;neurogenesis;Neurologic;neurological rehabilitation;neuron development;Neuronal Dysfunction;Neurons;Neuropathogenesis;neuropathology;normal aging;old mice;Outcome;Pathway interactions;Patients;Permeability;post stroke;Proliferating;protein expression;Proteins;Recovery;Rehabilitation therapy;Research;Risk Factors;Sampling;Severities;Signal Transduction;Sodium Fluorescein;Stains;stem cell fate;Stroke;stroke outcome;stroke recovery;stroke survivor;targeted treatment;Therapeutic;Tight Junctions;Tissues;trafficking;Transgenic Organisms;translational medicine;Vascular Diseases;vascular injury;Western Blotting

PROJECT_TITLE: Ischemic Stroke in Cerebral Amyloid Angiopathy: Microvascular Injury and Recovery


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is an adult-onset neurodegenerative disease that causes loss of cognitive function and death. There are no effective and long-term therapies for AD partly because of the failure to translate discoveries made in rodents to humans. To overcome this limitation, this proposal will optimize an approach to study mouse models of AD in a pathogen-rich environment and with a matured immune system to accelerate basic and translational research to treat the disease.

PI_NAMEs: VALDEZ, GREGORIO  (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid;amyloid pathology;Amyloidosis;Animal Model;Animals;Antigens;Basic Science;Brain;Brain region;Brain Stem;CD8B1 gene;Cell Maturation;Cells;Cessation of life;cognitive function;commensal microbes;Data;defined contribution;design;Development;Disease;effective therapy;Environment;experimental study;Exposure to;Failure;Female;fighting;Flow Cytometry;Future;Genetic;Genetic Transcription;germ free condition;Gliosis;Hippocampus;Human;human disease;human model;Immune;Immune response;Immune system;Immunohistochemistry;Impaired cognition;Incidence;indexing;Infiltration;insight;Laboratories;Liver;lymph nodes;Lymphoid;Lymphoid Tissue;male;Masks;Medial;Microbe;microbial;Microglia;Modeling;Molecular;monocyte;mouse model;Mus;Neurodegenerative Disorders;neuron loss;neuropathology;novel;novel strategies;Organ;pathogen;Pathogenesis;pathogenic microbe;Pathologic;Pathway interactions;Peripheral;Phenotype;Play;Population;Prefrontal Cortex;prevent;Publishing;Regimen;Regulatory T-Lymphocyte;Reporting;Reproducibility;Research;Research Personnel;residence;Rodent;Role;Senile Plaques;Spleen;Stains;Synapses;T cell differentiation;tau Proteins;Tauopathies;Testing;Tissues;trafficking;trait;Translating;Translational Research;transmission process;trend;Visualization;Work

PROJECT_TITLE: Development of a microbial-rich exposure regimen to accelerate translational research using mouse models of Alzheimer's Disease to humans.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The social, economic, and healthcare disruption during the COVID-19 pandemic amplified the vulnerability of people with existing and at risk of developing OUD, leading to the highest overdose death toll since 2017. The rationale for the proposed research is that once we understand how the COVID-19 pandemic altered social, economic, and healthcare systems, we can design more effective interventions for people with opioid use disorder. This research will be essential for informing optimal policy responses (now and in the future) and will align with the NIH NIDA’s goal to understand the economic and clinical impact of the COVID-19 pandemic on individuals, families, and communities with existing/at-risk of opioid use disorder.

PI_NAMEs: ADAMS, MEREDITH C. B.;HILL, ELAINE L (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 2019-nCoV;Adherence;Adolescent;Affect;Age;Behavior;Cause of Death;Cessation of life;Cicatrix;Clinical;clinically relevant;Color;Communities;Complex;contextual factors;County;COVID-19;COVID-19 impact;COVID-19 incidence;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Set;design;Development;Diagnosis;disability;Disparate;Disparity;Economic Conditions;Economic Factors;economic impact;Economics;effective intervention;electronic health data;Electronic Health Record;ethnic minority;Ethnic Origin;experience;Family;Future;Goals;Health;health care availability;health care delivery;health disparity;Healthcare;Healthcare Systems;improved;Incidence;Individual;individual patient;Inequality;Insurance Coverage;Measures;medically underserved;Medicare/Medicaid;Methods;minority communities;mortality;National Institute of Drug Abuse;Natural experiment;Neighborhoods;older adult;opioid epidemic;opioid use disorder;Outcome;Outcomes Research;overdose death;pandemic disease;pandemic impact;pandemic response;Personal Satisfaction;Persons;Policies;Population;Populations at Risk;pre-pandemic;Pregnancy;Prevalence;prevent;Public Health;Quasi-experiment;Race;racial minority;Records;Relapse;Research;response;Risk;Running;side effect;social;Social Distance;Social isolation;Social Network;social vulnerability;Stimulus;Subgroup;Testing;Unemployment;United States National Institutes of Health;Vaccination;vaccine acceptance;Vaccines;vulnerable community;Vulnerable Populations;welfare;Work

PROJECT_TITLE: COVID-19 Pandemic Mitigation, Community Economic and Social Vulnerability, and Opioid Use Disorder


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative The proposed research aims to establish novel strategies and synthetic approaches to advance and enrich gold catalysis and, more importantly, provide methodologies for biological and medicinal related target, which are otherwise very difficult to acquire due to their scarcity, structural complexity, and high cost. This research will also open new avenues toward collections of structurally novel small molecules that enable the construction of chemical libraries for lead compound identification, optimization processes for health and medicinal related chemical production, initiation of new building blocks as biological probes and novel therapeutics. The strategies and methodologies developed in this research will significantly enrich the toolbox of both synthetic chemists and medicinal chemists.

PI_NAMEs: SHI, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: 3-hydroxybutanal;Acids;Alkenes;Alkynes;Azoles;Biochemistry;Biological;biological research;carbene;Carbon;Catalysis;catalyst;chemical synthesis;Chemicals;Chemistry;Collection;cost;Coupling;Development;Employment;Funding;Goals;Gold;Health;Human;Hydrogen Bonding;insight;Investigation;Iron;Lead;Ligands;Macrocyclic Compounds;Medicine;Methodology;Methods;Molecular Probes;novel;novel strategies;novel therapeutics;nucleophilic addition;Organic Synthesis;Outcome;Oxidants;oxidation;Oxidation-Reduction;Pathway interactions;Periodicity;Phosphines;photoactivation;Physical condensation;Preparation;prevent;Process;process optimization;Production;programs;Reaction;Reporting;Research;Research Project Grants;Rest;Science;Skeleton;small molecule;small molecule libraries;stereochemistry;Structure;System;Therapeutic;Transition Elements;United States National Institutes of Health;Work

PROJECT_TITLE: Developing Asymmetric Gold Redox Catalysis for Challenging Chemical Transformations

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The proposed study will quantify how racial disparities in colorectal cancer survival are produced by racial differences in tumor characteristics, measured by gene-expression molecular subtypes, driver genes, and clinicopathologic factors. We will conduct the first large molecular epidemiologic study to compare survival outcomes of non-Hispanic African Americans to non-Hispanic whites using tumor data measured at the transcriptomic-, genomic- and pathologic-level. The study results will inform future clinical studies of targeted therapeutics and provide the foundation to reduce the racial disparity in survival experienced by African Americans.

PI_NAMEs: WARREN ANDERSEN, SHANEDA  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: African American;African American population;African race;Age;Age of Onset;Anatomy;Aspirin;Bioinformatics;Biological;black women;BRAF gene;Cancer Biology;Cancer Etiology;cancer health disparity;Cancer Prognosis;cancer survival;caucasian American;Cessation of life;Characteristics;Classification;Clinical;Clinical Research;cohort;Cohort Studies;colon cancer patients;Colorectal Cancer;colorectal cancer screening;colorectal cancer treatment;Communities;Complex;Consensus;Data;Data Sources;Death Rate;Diabetes Mellitus;Diagnosis;differences in access;Disease;Disparity;Education;Epidemiology;epidemiology study;experience;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profiling;Genes;Genomics;Goals;Household;improved;Income;innovation;insight;Intervention Studies;Knowledge;Link;Malignant Neoplasms;Measures;men;Mesenchymal;Microsatellite Instability;Modeling;Molecular;Molecular Epidemiology;Molecular Epidemiology of Cancer;Molecular Profiling;molecular subtypes;mortality;Mutation;mutational status;Natural History;Not Hispanic or Latino;novel;Outcome;Participant;Pathologic;Pattern;Population;Poverty;Precision Health;precision medicine;Prevalence;prognostic;Prognostic Factor;Prognostic Marker;Property;Race;racial difference;racial disparity;racial population;Randomized, Controlled Trials;Research;research study;Resources;Sampling;Screening for cancer;secondary analysis;Smoking;Socioeconomic Status;Somatic Mutation;survival disparity;survival outcome;Survival Rate;targeted treatment;The Cancer Genome Atlas;Tissue Sample;transcriptome sequencing;transcriptomics;tumor;Tumor Biology;Tumor Markers;Tumor Subtype;Tumor Tissue;uptake;Woman;Women's Health

PROJECT_TITLE: Understanding the Contribution of Colorectal Cancer Tumor Characteristics to Disparities in Colorectal Cancer Survival

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: As the number of older adults increases, many older adults live with conditions that profoundly impact their health, well-being, and ability to maintain independence. Artificial Intelligence offers an unprecedented opportunity to mitigate the impact of aging, to arm health care providers with new tools and to empower older adults including those with Alzheimer’s Dementia and their caregivers. The Johns Hopkins AI and Technology Collaboratory ecosystem will serve as a national resource to promote and guide the development and implementation of novel AI and technology approaches to improve care and health outcomes for older Americans.

PI_NAMEs: ABADIR, PETER M.;BATTLE, ALEXIS ;CHELLAPPA, RAMA  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;American;Area;arm;Artificial Intelligence;artificial intelligence algorithm;Biometry;Businesses;Capital;Caregivers;Caring;Center Core Grants;Chronic Disease;Clinic;Clinical;Clinical Services;clinical translation;collaboratory;Communication;Communities;Community of Practice;Computer Vision Systems;Country;Data;Data Science;Dedications;deep learning;Dementia;design;Development;Ecosystem;Education;Elderly;empowerment;Endowment;Equity;experience;feasibility testing;functional decline;Funding;Gerontology;Goals;Guidelines;Health;Health Personnel;Health Promotion;Health Resources;Health Services Research;Healthcare;Healthcare Industry;Healthcare Systems;Human;Image;Impaired cognition;improved;Individual;Industry;industry partner;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;International;Iowa;Leadership;Medical;Mentors;Methods;Mission;Movement Disorders;Natural Language Processing;Nerve Degeneration;new technology;next generation;novel;older adult;Older Population;Outcome;Parkinson Disease;Personal Satisfaction;Persons;Phase;Pilot Projects;pilot test;Policies;Population Heterogeneity;Privatization;Process;product development;programs;Quality of life;Records;Reporting;Research;Research Personnel;resilience;Resources;Robot;Rural Community;Rural Health;rural underserved;Science;Scientific Advances and Accomplishments;searchable database;sensor;skills;speech processing;stakeholder perspectives;Technology;technology development;technology platform;Testing;tool;Training;Training and Infrastructure;trend;underserved rural area;United States;Universities;urban area;Urban Community;urban underserved;Validation;Veterans;Vision;Voice;Work

PROJECT_TITLE: Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults


NIH_SPENDING_CATS: Aging;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CHELLAPPA, RAMA  (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;Alzheimer's Disease;Area;Artificial Intelligence;Award;Baltimore;Businesses;Capital;Clinical;Clinical Medicine;clinical practice;Clinical Research;Collaborations;collaboratory;Communication;cost effectiveness;Country;Data;data sharing;Development;Documentation;Engineering;experience;Family member;Feedback;Goals;Health;improved;Industry;innovation;Institution;Iowa;Knowledge;Lead;Leadership;Maintenance;meetings;Monitor;Names;older adult;Organization and Administration;Personal Satisfaction;Pilot Projects;Principal Investigator;Process;product development;Productivity;Program Reviews;programs;quality assurance;Quality Control;Records;Report (document);Research;research and development;Research Infrastructure;resilience;rural area;Rural Population;rural underserved;Safety;Science;Structure;Technology;technology development;Textbooks;underserved area;Universities;Urban Population;Vision;web site;Work


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

PHR: Project Narrative Candida lusitaniae is an opportunistic fungal pathogen known for its development of antibiotic resistance, that is a close relative to the multi-drug resistant pathogen Candida auris that is associated with hospital outbreaks. We study two types of mutations that arose repeatedly in C. lusitaniae infections and revealed new biology about pathways relevant for host interactions in diverse Candida species including C. auris.

PI_NAMEs: HOGAN, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: active control;Affect;airway inflammation;anti-fungal agents;anti-microbial peptide;Antibiotic Resistance;Azole resistance;Bacterial Infections;Bacterial Toxins;Biology;Candida;Candida auris;Candidiasis;Cells;Chronic;chronic infection;Coculture Techniques;Collaborations;Complex;cystic fibrosis patients;Data;Death Rate;Development;Disease Outbreaks;DNA Binding;Drug resistance;Environment;Event;Evolution;Fermentation;fitness;Frequencies;fungus;Genes;Genetic;Genomics;Glycolysis;Growth;health care settings;Heterogeneity;Hospitals;Hydrogen Peroxide;in vivo;Induced Mutation;Infection;Inflammation;inflammatory milieu;Iron;loss of function mutation;Lung infections;Metabolic;Metabolism;metabolomics resource;Metals;Mitochondria;Modeling;Modification;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Mutation;Mycoses;neutrophil;novel therapeutic intervention;Oxidative Stress;pathogen;pathogenic fungus;Pathway interactions;Phenotype;Phylogenetic Analysis;Physiology;Population;Production;Productivity;programs;Proteins;Publishing;Pyruvaldehyde;Regulon;Reporting;Resistance;Resistance development;Respiration;response;Signal Transduction;Stress;Surface;System;Testing;Time;tool;trait;transcription factor;transcriptomics;transmission process;Treatment Failure;treatment strategy;uptake;Variant;Work

PROJECT_TITLE: Evolved Heterogeneity Contributes to Chronic Fungal Lung Infections

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SCHOENBORN, NANCY  (contact)

PROJECT_TERMS: acceptability and feasibility;Accountability;Aging;Applications Grants;Area;Artificial Intelligence;Caregivers;Caring;Categories;collaboratory;Communities;Dementia;design;Development;Dissemination and Implementation;Educational workshop;Ensure;Environment;Equity;Ethics;experience;Face;feasibility testing;Feedback;Focus Groups;Goals;Grant;Health;health equity promotion;Health Professional;Health system;Healthcare;Impaired cognition;improved;informant;Infrastructure;insight;Interdisciplinary Study;Intervention;Interview;Lived experience;member;Methods;Mission;multidisciplinary;Needs Assessment;new technology;older adult;Outcome;Outcomes Research;outreach;Ownership;patient oriented;Patient Recruitments;Patient-Centered Care;Patients;Personal Satisfaction;Persons;Phase;phrases;Pilot Projects;Policy Maker;preference;Program Research Project Grants;programs;prototype;Public Health Informatics;Quality of life;Questionnaires;recruit;repository;Research;Research Personnel;resilience;Resources;Review Literature;routine care;Sampling;Scanning;shared decision making;stakeholder perspectives;Structure;success;Surveys;symposium;Technology;technology development;Testing;Training;Trust;Work

PROJECT_TITLE: Stakeholder Engagement Core


NIH_SPENDING_CATS: Aging;Bioengineering;Caregiving Research;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HAGER, GREGORY DONALD (contact)

PROJECT_TITLE: Technology Identification and Training Core


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Advanced Development;Advertising;Aging;Ambulatory Care;Area;Artificial Intelligence;artificial intelligence algorithm;Caring;Clinic;Clinical;Clinical Research;clinical training;clinical translation;Cognition;Cognitive;Collaborations;collaboratory;Communities;Consent;Data;Data Analyses;Data Collection;Dementia;design;Development;Development Plans;Devices;Documentation;Eligibility Determination;Engineering;Ensure;experience;feasibility testing;frailty;Future;Geriatrics;Goals;Health Technology;Home;human subject;human subject protection;Human Subject Research;Impaired cognition;Institutional Review Boards;interest;Intervention;Laboratories;Leadership;Long-Term Care;Maintenance;Measurement;Medical center;Mentorship;Methods;Minority Recruitment;Monitor;Nursing Homes;older adult;Older Population;Outcome;Performance;Physical Function;Pilot Projects;Preparation;Primary Care;Procedures;programs;protocol development;prototype;recruit;Registries;Research;Research Design;Research Personnel;resilience;Resources;Safety;Scientist;Site;skills;synergism;Technology;technology development;technology validation;Testing;Training;Translational Research;Translations;Trust;Universities;Validation;Work

PROJECT_TITLE: Clinical Translation and Validation Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PUBLIC HEALTH RELEVANCE Autism spectrum disorder (ASD) affects 1 in 68 children in the US. As many as a third of children with ASD remain minimally verbal (MV), producing very few if any spoken words by the time they reach kindergarten. This project is focused on identifying novel risk factors for remaining MV, with implications for guiding and focusing early intervention efforts.

PI_NAMEs: BRADY, NANCY CAROLINE;ROZGA, AGATA  (contact)

PROGRAM_OFFICER_NAME: COOPER, JUDITH

PROJECT_TERMS: Affect;Age;Age Months;Agreement;alternative communication;Attention;autism spectrum disorder;autistic children;Behavior;Child;Child Development;Child Language;Classification;Communication;Communities;Comprehension;Computer Models;Data;Data Set;data-driven model;Development;Diagnosis;Dimensions;Early Intervention;Education;effective intervention;experience;Failure;Foundations;Gestures;high risk;High-dimensional Modeling;Individual;innovation;Intervention;joint attention;Joints;kindergarten;Knowledge;Language;language outcome;Learning;Life;Linguistics;Literature;markov model;Measurement;Methods;minimal risk;minimally verbal;model development;model of autism spectrum disorder;Modeling;Nature;novel;Outcome;Pathway interactions;Pattern;predictive modeling;Predisposing Factor;public health relevance;Research;Research Personnel;Risk;Risk Factors;risk prediction model;Sampling;Science;skill acquisition;skills;Survival Analysis;Testing;Time;Training;training data;Validation;verbal;vocalization

PROJECT_TITLE: Discovering novel predictors of minimally verbal outcomes in autism through computational modeling

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


PI_NAMEs: PHAN, PHILLIP  (contact)

PROJECT_TERMS: Academia;Acceleration;Advocacy;Aging;American;Artificial Intelligence;artificial intelligence algorithm;Assisted Living Facilities;Big Data;Biology of Aging;Biometry;Businesses;Center Core Grants;Clinical;clinical practice;Clinical Research;Collaborations;commercialization;Data;design;Development;Devices;Diagnostic;disadvantaged background;Education;Educational workshop;Electronics;Entrepreneurship;Environment;Ethnic Population;Event;evidence based guidelines;Family;Feedback;Geriatrics;Goals;Government;Health;Health Personnel;Health Services Research;healthy aging;Home;ideation;Image;improved;Individual;Industry;innovation;Institution;interest;Intervention;Journals;Knowledge;Marketing;Maryland;medical schools;meetings;member;Mentors;Mission;Modality;next generation;novel;older adult;Online Systems;Operations Research;outreach;Participant;patient safety;Patients;Persons;Pilot Projects;Policies;Policy Analysis;Policy Maker;Printing;programs;Provider;Publishing;racial population;remote sensor;Research;resilience;Resources;Robot;Role;Schools;Science;Services;Social Work;Societies;support tools;symposium;Talents;Technology;technology development;technology platform;Training;Translations;Triage;Universities;Update;Voice;Work

PROJECT_TITLE: Networking and Mentoring Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Lung;Rare Diseases;Sickle Cell Disease

PHR: PROJECT NARRATIVE This project will investigate the role of new genetic markers as risk factors for the development of acute chest syndrome, a major cause of death in patients with sickle cell disease. We will also investigate the role of genetic markers as a tool to identify patients with acute chest syndrome.

PI_NAMEs: MACHADO, ROBERTO F. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;acute chest syndrome;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Admission activity;beta Chain Antigen T Cell Receptor;Biogenesis;Biological Markers;Blood Vessels;career;Cause of Death;CDKN1A gene;Cell Adhesion Molecules;Cessation of life;Chronic;clinical care;Critical Pathways;Death Rate;Development;diacylglycerol O-acyltransferase;Endothelial Cells;Endothelium;Erythrocytes;Funding;Genes;Genetic;genetic approach;Genetic Markers;Genomic approach;Genomics;health disparity;Hospitalization;Hour;Hypoxia;Impairment;improved;Individual;Inflammatory;Inflammatory Response;insight;Lipids;Lung;lung injury;meter;molecular marker;Molecular Target;Morbidity - disease rate;mortality;Mus;novel;novel strategies;Pathway interactions;Patient Care;Patients;Physicians;Predisposition;premature;pulmonary vascular disorder;Ras Signaling Pathway;Resistance;response;Risk;Risk Factors;Role;Scientist;Severities;Sickle Cell Anemia;Syndrome;Systems Biology;T-cell receptor repertoire;Testing;Therapeutic;therapeutic target;Time;tool;translational approach;translational study

PROJECT_TITLE: Vascular Targeting Genomic & Genetic Strategies for Acute Chest Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: SAMUS, QUINCY MILES (contact)

PROJECT_TERMS: access disparities;Address;advanced dementia;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;Award;Big Data Methods;Biological Markers;Biometry;Businesses;Caregivers;Caring;clinical translation;Collaborations;collaborative approach;collaboratory;commercialization;Communication;Conceptions;Contracts;Copyright;Data;Dementia;dementia care;design;Development;Diagnostic;Digital biomarker;Electronic Health Record;Ensure;Environment;Funding;Goals;Health;health determinants;health disparity;Image;improved;Information Dissemination;innovation;Leadership;Legal patent;Licensing;Machine Learning;meetings;member;Mentors;multidisciplinary;Natural Language Processing;new technology;older adult;operation;Personal Satisfaction;Persons;Phase;Pilot Projects;Process;product development;program dissemination;Qualifying;Quality of Care;Research;Research Personnel;resilience;Resources;Robotics;Rural;rural area;Selection Criteria;Series;Sister;smart device;Speech;Standardization;Structure;success;System;Technology;technology development;Translations;Urban Population;urban underserved;Validation

PROJECT_TITLE: Pilot Core (AD/ADRD Focus): Technology Development and Refinement


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: WALSTON, JEREMY D (contact)

PROJECT_TERMS: access disparities;Aging;Alzheimer's Disease;American;Award;Big Data Methods;Biological Markers;Biometry;Businesses;Capital;Caregivers;Clinical;Collaborations;collaborative approach;Communication;Conceptions;connected care;Data;data platform;design;Development;Diagnostic;Ecosystem;Ensure;frailty;functional decline;Funding;Goals;Health;health care delivery;health disparity;Healthcare;improved;innovation;Leadership;Machine Learning;Maintenance;Medicine;Mentors;multidisciplinary;Names;Natural Language Processing;older adult;Older Population;Patient Care;patient engagement;Personal Satisfaction;Phase;Pilot Projects;Prevention;Process;product development;Research;Research Personnel;resilience;Resources;Robotics;rural area;Rural Health;Series;smart device;Social isolation;Standardization;System;Technology;technology development;Testing;Training;Translations;urban area;Urban Health

PROJECT_TITLE: Pilot Core (Aging Focus): Technology Development and Refinement


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: CHUTE, CHRISTOPHER G (contact)

PROJECT_TERMS: Acceleration;Artificial Intelligence;Clinical Data;Clinical Research;cloud based;Collaborations;Common Data Element;Country;Data;Data Analyses;Data Collection;data framework;data integration;Data Management Resources;data modalities;data platform;data quality;Development;Devices;Disparate;Electronic Health Record;Ensure;Evaluation;experience;Fast Healthcare Interoperability Resources;Feeds;flexibility;Goals;Health;heuristics;high standard;improved;inquiry-based learning;Intervention;Laboratories;Machine Learning;medical schools;mHealth;NCI Thesaurus;older adult;Outcome;Patient risk;Patients;Personal Satisfaction;Physics;Pilot Projects;precision medicine;Public Health Schools;Reporting;Research;Research Personnel;resilience;Resources;Secure;Semantics;sensor;Services;Source;Surveys;System;Systems Analysis;Technology;technology development;Terminology;Unified Medical Language System

PROJECT_TITLE: Data Integration and Quality Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative There is a pressing need for new vaccines and antivirals against SARS-CoV2, the cause of COVID-19, which requires both animal models that reproduce COVID-19 disease signs and an understanding of the factors that drive susceptibility to virus-induced disease. Therefore, we will use the Collaborative Cross (CC) to develop improved mouse models of COVID-19 disease, while also identifying polymorphic host genes that drive susceptibility to nCoV2-induced disease.

PI_NAMEs: BARIC, RALPH S;HEISE, MARK T (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Affect;Age;Animal Model;Anti-viral Agents;Candidate Disease Gene;Cessation of life;Coronavirus;coronavirus disease;coronavirus vaccine;COVID-19;COVID-19 pathogenesis;COVID-19 pneumonia;COVID-19 susceptibility;COVID-19 vaccine;CRISPR/Cas technology;Development;Disease;Disease Outcome;Disease susceptibility;disorder risk;Exhibits;experience;Factor Analysis;Gender;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic Variation;genomic locus;Haplotypes;Health;Healthcare Systems;Homeostasis;Human;human model;Immune;Immune response;Immunity;improved;Individual;Infection;Inflammatory;influenzavirus;insight;Integration Host Factors;Knowledge;Laboratories;Laboratory mice;Lung;male;Maps;Medical;men;Middle East Respiratory Syndrome Coronavirus;Modeling;monocyte;mouse model;Mouse Strains;Mus;nonhuman primate;novel coronavirus;novel vaccines;Older Population;pandemic disease;pathogen;Pathogenesis;Pathway interactions;Patients;permissiveness;phenotypic data;Preclinical Drug Evaluation;Preclinical Testing;Predisposition;prognostic assays;Public Health;Pulmonary Pathology;Quantitative Trait Loci;remdesivir;Research;Resistance;resistant strain;respiratory infection virus;Respiratory physiology;response;Risk;Risk Factors;Safety;SARS coronavirus;sex;Shapes;Statistical Models;Susceptibility Gene;Testing;Therapeutic;Vaccines;Variant;Virus;Virus Diseases;Work;zoonotic coronavirus

PROJECT_TITLE: Genetic Analysis of COVID-19 Susceptibility and Resistance Determinants in the Collaborative Cross

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Precision Medicine;Rare Diseases

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Indeterminate mass lesions are present on over 1% of brain MRIs in individuals over 45 years old, and misinterpretation of brain MRI can lead to significant iatrogenic morbidity and mortality. To prevent iatrogenic morbidity, there is a critical need for scalable and reproducible methods to distinguish indeterminate brain lesions from each other, and to accurately diagnose brain tumors prior to biopsy. We hypothesize that both germline genotyping and MRI-based machine learning provide an opportunity to diagnose indeterminate mass lesions as well as predict glioma molecular subtype prior to surgery and thus personalized treatment.

PI_NAMEs: ECKEL PASSOW, JEANETTE E (contact);TOBIN, W. OLIVER

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Academic Medical Centers;accurate diagnosis;Adult;Biological Assay;Biopsy;Brain;brain magnetic resonance imaging;Brain Neoplasms;Brain Pathology;Central Nervous System;Central Nervous System Lymphoma;Central Nervous System Neoplasms;Characteristics;Clinical;clinically significant;cohort;cost;Data;Demyelinating Diseases;Development;Diagnosis;Diagnostic;diagnostic accuracy;Differential Diagnosis;Diffuse;Effectiveness;Excision;Genotype;Germ Lines;Germ-Line Mutation;Glioma;Iatrogenesis;Image;improved;Individual;Inflammatory;Lead;Lesion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Metastatic malignant neoplasm to brain;Methods;Modeling;molecular subtypes;Morbidity - disease rate;mortality;Multiple Sclerosis;Mutate;Neoplasm Metastasis;Operative Surgical Procedures;Outcome;Pathologic;Patient Care;Patients;personalized medicine;Predictive Value;Predisposition;prevent;Primary Brain Neoplasms;prospective;Prospective cohort;Prospective, cohort study;Publishing;Radiation;Reproducibility;Research;Risk;risk variant;Running;Sensitivity and Specificity;Site;Specificity;tool;Training;tumor;Tumor Debulking;Work

PROJECT_TITLE: Diagnosis of indeterminate brain lesions using MRI-based machine learning and polygenic risk models

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE There are an estimated 7 million stroke survivors living in the United States. More than two-thirds of these have residual paralysis of the upper limb, and of them, ~37%-50% have severe paralysis. There are few treatment options that are appropriate or effective for patients with severe paresis. Here, we will test whether the combination of a unique rehabilitation therapy that is easy to administer in patients with little to residual motion and a new brain stimulation technique that taps into intact neural resources would produce higher gains in upper limb function than those that can be achieved with conventional treatment in patients with severe paralysis. ! !

PI_NAMEs: PLOW, ELA B (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Activities of Daily Living;Affect;Area;Articular Range of Motion;Brachial Paresis;Brain;Chronic;chronic stroke;Clinical;clinically relevant;Contralateral;conventional therapy;Development;effective therapy;Equilibrium;experience;Extensor;Fingers;FPS-FES Oncogene;functional electrical stimulation;functional gain;functional independence;functional restoration;Goals;Hand;hand dysfunction;Hemiplegia;Impairment;improved;Intervention;Left;limb movement;Limb structure;Measures;Motion;Motor;motor control;Motor Cortex;motor impairment;Movement;multimodality;neural;neuromuscular stimulation;Neuronal Plasticity;neurophysiology;new therapeutic target;noninvasive brain stimulation;novel therapeutics;Outcome;Output;Paralysed;Paresis;Participant;Pathway interactions;Patients;post stroke;Randomized;Recovery Support;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Residual state;Resources;Self Care;sensor;Shapes;Shoulder;stroke patient;stroke survivor;stroke therapy;Techniques;Testing;theories;Thumb structure;Transcranial magnetic stimulation;Underserved Population;United States;Upper Extremity;Wrist

PROJECT_TITLE: Contralaterally Controlled FES Combined with Brain Stimulation for Severe Upper limb Hemiplegia

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project aims to analyze the role of the Plant Homeodomain 6 gene in hematopoietic stem cell aging using a combination of cellular and animal models. Our integrative approach brings together cellular and molecular assays profiling cell intrinsic and cell extrinsic mechanisms implicated in hematopoietic stem cell self-renewal and function with the goal of elucidating the specific mechanisms implicated in enhanced hematopoietic stem cell function with the abrogation of aging phenotypes in Phf6 knockout stem and progenitor cells.

PI_NAMEs: PALOMERO, TERESA  (contact);RABADAN, RAUL

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Age;age related;Age related pathologies;aged;Aging;Anabolism;analytical tool;Animal Model;Biogenesis;Biological Assay;Bone Marrow;Cell Adhesion;cell age;Cell Aging;Cell Compartmentation;Cell Cycle Kinetics;Cell Cycle Progression;Cell division;Cell model;cell motility;Cell Nucleolus;Cell Physiology;Cell Proliferation;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computational Biology;conditional knockout;cytokine;Deacetylase;Deterioration;Development;DNA Damage;Engraftment;Epigenetic Process;epigenomics;Event;exhaust;experimental study;fitness;functional decline;Generations;Genes;Genetic;Genetic Transcription;genome integrity;Goals;Health;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;HIF1A gene;homeodomain;Homing;Human;Immunophenotyping;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Knock-out;Knockout Mice;leukemic transformation;Life Expectancy;Lymphoid;Mediating;Mediator;Metabolism;Molecular;Myelogenous;new therapeutic target;Nucleosomes;Organ;Pathology;Phenotype;Plants;Play;Population;Positioning Attribute;pro-aging;programs;Proliferating;Proteins;Regulation;response;Ribosomes;Role;self-renewal;senescence;Somatic Mutation;stem;stem cell aging;Stem Cell Assay;stem cell function;stem cells;Stress;Testing;therapeutic development;Therapeutic Intervention;transcriptomics;Translations;Transplantation

PROJECT_TITLE: The role of PHF6 in the control of hematopoietic stem cell aging.

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Child maltreatment is known to have pervasive effects on both short- and long-term physical and mental health. The proposed work will identify whether perturbation in the stress system in adolescence links maltreatment with disease risk in young adulthood and identify moderators that may hinder or promote potential HPA axis resilience. Findings will provide the first evidence demonstrating whether recalibration of the HPA axis in adolescence can mitigate the effects of early trauma on disease risk in young adulthood.

PI_NAMEs: NEGRIFF, SONYA L (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Adolescence;Adolescent Development;Adult;aging process;allostatic load;Biological;biological adaptation to stress;Biological Aging;Biological Markers;Body mass index;C-reactive protein;Calibration;Cardiovascular Diseases;Caregivers;Cells;Child;Child Abuse;Child Abuse and Neglect;child neglect;Childhood;Chronic;Chronic Disease;Clinical;Communities;comparison group;cost;Data;Data Set;Development;Disease;disorder risk;early life stress;Early-life trauma;Economic Burden;Enrollment;Epigenetic Process;Ethnic Origin;experience;follow up assessment;Functional disorder;Future;Health;hypothalamic-pituitary-adrenal axis;Immune;improved;indexing;Individual;Individual Differences;Inflammatory;innovation;insight;Interleukin-6;Intervention;Knowledge;Life;Link;longitudinal dataset;Longitudinal Studies;Lung Diseases;Malignant Neoplasms;maltreatment;Measures;Mediation;Mental Health;Metabolic syndrome;Modeling;Morbidity - disease rate;mortality;Outcome;Pathway interactions;Pattern;physical conditioning;Physiological;prevent;Prevention;Process;prospective;protective factors;racial minority;Recording of previous events;Regulation;Reporting;resilience;response;Risk;Risk Factors;Role;Self Perception;Severities;Shapes;social;Social support;Stress;Symptoms;System;Techniques;Testing;Time;TNF gene;transmission process;Trauma;Vulnerable Populations;Well in self;Work;young adult;Youth

PROJECT_TITLE: Childhood Maltreatment and Disease Risk in Young Adulthood: The Role of HPA Regulation in Adolescence

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic hepatitis B remains a significant public health burden affecting approximately 257 million individuals worldwide, who suffer from a high risk of developing cirrhosis and liver cancer. HBV infection is maintained by a persistent viral genome called cccDNA, which could not be eradicated by currently approved drugs. We propose in this application to elucidate the molecular mechanisms of cccDNA formation, which will aid the development of novel therapeutics to cure HBV.

PI_NAMEs: GUO, HAITAO  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Adverse effects;Affect;Anabolism;analog;Binding;Biochemistry;Biogenesis;Biology;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chemicals;chromatin immunoprecipitation;Chronic;Chronic Hepatitis B;Circular DNA;Cirrhosis;comparative;Complement;Complex;Cytoplasm;Data;Development;DNA;DNA Ligases;DNA Repair;DNA Repair Gene;Drug resistance;effective therapy;Employment;Episome;Excision;Exhibits;Failure;Flap Endonucleases;Genes;Genetic Transcription;Genome;Genomics;Goals;Guanosine;HBV Animal Model;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;high risk;Human;Immunocompetent;Individual;Infection;insight;Interferon alpha;knock-down;Life Cycle Stages;Ligation;Link;Liver;Longevity;Maintenance;Malignant neoplasm of liver;Maps;Mass Spectrum Analysis;Messenger RNA;Minor;Molecular;Molecular Biology;mouse model;Mus;Mutagenesis;Nature;novel;novel therapeutics;Nuclear;Nucleocapsid;Nucleotide Excision Repair;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;phosphodiester;phosphoric diester hydrolase;Play;Polymerase;Predisposition;Primary carcinoma of the liver cells;Process;Production;Proteins;Proteome;Proteomics;Public Health;receptor;Recycling;Relaxation;Reporting;Research;response;Reverse Transcription;Risk Factors;RNA;RNA primers;Role;Side;Signal Transduction;stable cell line;Study models;targeted treatment;Technology;terminal redundancy;timeline;Transcript;transcriptome;Transportation;tyrosyl-DNA phosphodiesterase;Viral;viral DNA;Viral Genome;viral genomics;viral rebound;Virus;Virus Diseases;Virus Inhibitors;Virus Replication;Work

PROJECT_TITLE: Molecular Mechanisms of HBV cccDNA Formation


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Hemodialysis treatment non-adherence is an important modifiable contributor in end-stage kidney disease (ESKD), with critical public health relevance to patients, providers, and health systems due to its association with excessive hospitalizations, exorbitant financial burden, and increased morbidity and mortality. Compared to Whites, African American ESKD patients have a four-fold higher ESKD prevalence, persistently higher hospitalization and rehospitalization risk, and higher rates of dialysis treatment non-adherence. The goals of this proposal are to evaluate the efficacy of culturally tailored motivational interviewing on improving hemodialysis treatment adherence in African Americans ; 2) provide a strong basis for conducting a future effectiveness and implementation trial using evidence-based, culturally tailored motivational interviewing intervention to improve hemodialysis adherence, and reduce hospitalizations, morbidity, mortality, and exorbitant financial burden associated with dialysis treatment non-adherence; and 3) promote health equity by reducing existing health disparities and optimizing outcomes in ESKD.

PI_NAMEs: UMEUKEJE, EBELE M (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Accounting;Address;Adherence;African American;African American population;Attention;behavior change;Behavior Therapy;Budgets;Caring;Chronic;Chronic Disease;Communities;Complex;compliance behavior;Counseling;culturally appropriate intervention;Data;Dialysis patients;Dialysis procedure;Disparity;effectiveness trial;effectiveness/implementation trial;efficacy evaluation;efficacy testing;empowerment;End stage renal failure;ethnic minority;evidence base;Evidence based intervention;Financial cost;Financial Hardship;Future;Goals;Health;Health behavior;health disparity;health equity promotion;Health equity research;Health system;health training;Hemodialysis;High Prevalence;hospital readmission;Hospitalization;improved;improved outcome;innovation;Intervention;intervention delivery;Kidney Diseases;Lead;Link;Medicare;medication compliance;Minority;Minority Groups;Mission;Modeling;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Patients;Population;Predictive Factor;Prevalence;Prevention;Process;Prospective cohort;Protocols documentation;Provider;psychosocial;Psychosocial Factor;Public Health;public health relevance;racial difference;racial minority;Randomized;randomized, clinical trials;Research;Research Priority;Risk;Testing;treatment adherence

PROJECT_TITLE: MOVE Trial: MOtiVational Strategies to Empower African Americans to Improve Dialysis Adherence

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Dementia is a leading cause of death in the United States, and disproportionately impacts individuals with less education and income. This proposal evaluates socioeconomic interventions that increased years of education (Aim 1) and income security (Aim 2) to determine if such interventions impacted dementia risk overall, and whether structurally minoritized groups (Black Americans, individuals from low childhood SES backgrounds, and people who grew up in rural areas or the South) differentially benefited (Aim 3). We hypothesize that these interventions reduced dementia risk overall, and that structurally minoritized groups benefitted more resulting in smaller socioeconomic, racial, and geographic disparities.

PI_NAMEs: VABLE, ANUSHA MURTHY (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Affect;Age;age related;Alzheimer's disease related dementia;Birth;Black American;Cause of Death;Cerebrovascular Disorders;Childhood;Chronic;Clinical;Cognition;Cognitive;cognitive reserve;cohort;college;Country;Data Set;Date of birth;Dementia;dementia risk;Diagnosis;Dimensions;Disease;disorder risk;Disparity;early life exposure;Education;Educational Intervention;Educational Status;Ethnic Origin;Evaluation;Future;geographic disparity;Geography;Goals;Health;Health and Retirement Study;Health behavior;health data;health disparity populations;higher education;Hypertension;improved;Incidence;Income;Income Tax;Individual;Institution;Intervention;late life;Life Cycle Stages;Link;Literature;Long-Term Effects;middle age;Minority Groups;National Longitudinal Survey of Youth;Neurodegenerative Disorders;Participant;Pattern;Pensions;Persons;Policies;Population;poverty alleviation;Preventive measure;Process;Publishing;Race;racial disparity;Randomized;Reasons for Geographic And Racial Differences in Stroke;Research;Retirement;Risk;rural area;Schools;Security;social health determinants;social interventions;Social Policies;Social Security;social vulnerability;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;stress reduction;Subgroup;Testing;trend;United States;United States National Institutes of Health;Variant;Veterans;Vietnam;Vulnerable Populations;War;Work

PROJECT_TITLE: Evaluation of college accessibility and income security interventions as preventative measures for dementia risk and solutions to dementia disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)]