NIH_SPENDING_CATS: Clinical Research;Hematology;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We are proposing a multi-institution study to address a severe hematopoietic stem cell transplant (HCT) complication called thrombotic microangiopathy or “TMA”. In our first aim we will define incidence, risk factors, phenotypic diversity, temporality between Graft-versus-host disease and TMA and role of markers of complement activation in diagnosis of HCT-TMA. In our second aim, we will identify key mechanisms of endothelial injury and complement activation after HCT that will result in identification of novel therapeutic targets.

PI_NAMEs: VASU, SUMITHIRA  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Adult;Age;Allogenic;Area;Biological;Biological Markers;Blood Banks;Caring;cell growth;Cell Therapy;Cells;chemotherapy;Child;Clinical;Clinical Data;clinical database;clinical diagnosis;Clinical Markers;clinical phenotype;Clinical Research;clinical risk;cohort;Cohort Studies;Collaborations;Complement;Complement Activation;Complication;conditioning;Consensus;Data;Death Rate;Development;Diagnosis;Diagnostic;diagnostic strategy;Early Diagnosis;Eligibility Determination;Endothelium;Enrollment;Etiology;Event;evidence based guidelines;Financial cost;Flare;Frequencies;Functional disorder;Future;graft vs host disease;Health;Hematopoietic Stem Cell Transplantation;Hemolytic Anemia;high risk;high risk population;Hospitalization;Immunosuppression;improved;Incidence;indexing;individual patient;Infection;inhibitor;Injury;Institution;Intensive Care Units;interest;Interferons;Interruption;Intervention;kidney dysfunction;Knowledge;Length;Life;Measures;Modality;Monitor;Mononuclear;Neurologic Symptoms;new therapeutic target;novel therapeutic intervention;Ohio;older adult;older patient;Older Population;Organ;organ injury;Outcome;Pathogenesis;Patient risk;Pediatric cohort;Persons;Phenotype;Plasma;Population;post-transplant;Predisposition;Prevention;Procedures;prospective;Prospective cohort;Prospective Studies;Publications;Publishing;Rehabilitation therapy;Renal function;Reporting;Resolution;Risk Factors;Role;routine screening;Sampling;screening;screening guidelines;Series;Serum;Stem cell transplant;Testing;Therapeutic;Therapeutically Targetable;thrombotic;Time;Toxic effect;transplant centers;Transplant Recipients;Transplantation;Universities;Work

PROJECT_TITLE: MIDAS: MIcroangiopathy, endothelial Damage in Adults undergoing Stem cell transplantation

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Human papillomavirus (HPV) is the most common sexually transmitted infection and is the primary cause of cervical, oropharyngeal, and anogenital cancers. Despite HPV’s heavy public health burden, there remains a limited understanding of the viral entry pathway. This proposal seeks to clarify the role of the dynein cargo adaptors FIP3 and BICD2 in dynein-mediated transport of HPV, which holds the potential to identify new therapeutic targets to combat pre-existing HPV infections.

PI_NAMEs: SPECKHART, KAITLYN NOEL (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Adaptor Signaling Protein;Anogenital cancer;Anti-viral Agents;Binding;Biochemical;Cancer Etiology;Capsid Proteins;Cell membrane;Cell Nucleus;Cells;combat;Complex;Cytosol;Data;Disease;DNA Viruses;ds-DNA;Dynein ATPase;Encapsulated;Endocytosis;endosome membrane;Endosomes;Etiology;Event;Exposure to;genetic approach;Genome;Goals;Golgi Apparatus;Human papilloma virus infection;Human Papillomavirus;Image;imaging approach;Infection;Integration Host Factors;Intracellular Transport;loss of function;Malignant neoplasm of cervix uteri;malignant oropharynx neoplasm;Mediating;Membrane;Minor;Mitosis;Modeling;Molecular;Motor;new therapeutic target;novel;novel strategies;Nuclear Envelope;particle;Pathway interactions;Peptide Hydrolases;prevent;Preventive vaccine;Public Health;receptor;receptor mediated endocytosis;recruit;Role;Route;Screening Result;secretase;Sexually Transmitted Diseases;Small Interfering RNA;Sorting;Testing;therapeutic development;trafficking;Transport Process;Vesicle;Viral;Virus

PROJECT_TITLE: Elucidating the role of dynein-cargo adaptor proteins in Human papillomavirus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Social Determinants of Health;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Kidney transplantation enables patients with end-stage kidney disease to live longer and better lives. Yet, where patients live has a major impact on whether they can get a transplant. This grant will evaluate the effect of geography and kidney allocation changes on efficiency and equity in kidney transplantation.

PI_NAMEs: POTLURI, VISHNU SAGAR (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: access disparities;Accounting;Affect;American;Appointment;Area;Beds;career;Clinical;Communication;Data;data registry;design;End stage renal failure;Epidemiology;Equity;experience;Faculty;Fostering;Funding;geographic difference;geographic disparity;Geographic Locations;Geography;Goals;Grant;Health;Health Service Area;Hospitals;Improve Access;improved;innovation;insight;Kidney;kidney allograft;Kidney Diseases;Kidney Transplantation;Location;Logistics;Low income;Maps;Mentorship;Methods;Minority;Minority Access;Nephrology;novel;Organ;organ allocation;Organ Donations;Organ Donor;Outcome;patient population;Patients;Pattern;Pennsylvania;Persons;Physicians;Policies;Population;Prevalence;Probability;Public Health;Radial;Research;residence;Resources;Risk;Role;Schedule;Scientist;Socioeconomic Status;System;Time;transplant registry;Transplantation;United Network for Organ Sharing;Universities;Variant;Visual;Vulnerable Populations;Wait Time;years of life lost

PROJECT_TITLE: Impact of Geographic Boundaries on Deceased Donor Kidney Discard, Allocation, and Outcomes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Breastfeeding, Lactation and Breast Milk;Clinical Research;Genetics;Human Genome;Lung;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Breast milk has immune regulating activities that instruct the neonatal immune system to become tolerant to certain antigens, and breastfeeding protects against the development of allergy and autoimmunity. This proposal seeks to understand how a common milk protein called butyrophilin can modulate the reactivity of T cells and whether butyrophilin is necessary for breast milk to prevent inappropriate immune responses. Successful completion of these studies will provide important knowledge about the mechanisms by which butyrophilin in breast milk contributes to immune tolerance in neonates, and why breast feeding protects against allergic and autoimmune diseases.

PI_NAMEs: KANG, INSOO ;WYSOLMERSKI, JOHN J (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: aerosolized;Affect;Age;Airway Disease;Allergic Disease;Antigens;apical membrane;Asthma;ATAC-seq;atopy;Autoimmune Diseases;Autoimmunity;beneficial microorganism;Breast Epithelial Cells;Breast Feeding;butyrophilin;CD3 Antigens;Celiac Disease;Cell Separation;Cells;Child;Chronic Childhood Arthritis;commensal bacteria;Consumption;Data;Defect;Development;Disease;Eczema;environmental allergen;epidemiology study;Epigenetic Process;Exposure to;Food;Fostering;Future;Goals;Growth;Healthcare;high reward;high risk;High-Throughput Nucleotide Sequencing;Human;Human Milk;Hypersensitivity;Immune;immune function;Immune response;Immune system;Immune Tolerance;Immunomodulators;immunoregulation;In Vitro;in vivo;Infant formula;Infection;Inflammatory Bowel Diseases;insight;Insulin-Dependent Diabetes Mellitus;Knockout Mice;Knowledge;Lactation;Life;Lipids;Lung Diseases;Maternal antibody;Mediating;member;Milk;milk microbiome;Milk Proteins;Modeling;Molecular;Mothers;Multiple Sclerosis;Mus;Neonatal;neonatal immune system;neonatal mice;neonate;Nutrient;offspring;old mice;Oligosaccharides;Ovalbumin;Pathway interactions;Peripheral Blood Mononuclear Cell;Population;prevent;protective effect;Protein Family;Pulmonary Inflammation;rapid growth;Recombinants;response;Risk;Rodent Model;Shapes;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Spleen;suckling;System;T-Cell Activation;T-Lymphocyte;Techniques;Testing;trafficking;translational impact;Variant;Weaning

PROJECT_TITLE: Milk Butryophilin and Immune Tolerence

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative: Sleep is essential for children’s daytime functioning and health. Poorer sleep hygiene can negatively affect sleep outcomes in children. Urban Latino children are at greater risk for poor sleep hygiene and poor quality sleep due to exposure to higher levels of urban and cultural stressors. We propose to evaluate a novel intervention to improve sleep hygiene and in turn, sleep duration in urban Latino middle school children. We will also identify factors that may enhance the acceptability and reach of the intervention to other Latino children and their families in additional urban areas through feedback from community partners. A culturally and contextually tailored sleep hygiene intervention has the potential to exert greater improvements in sleep hygiene and sleep outcomes for group that may be more vulnerable to poor sleep health.

PI_NAMEs: CHAVEZ, LIGIA M.;KOINIS MITCHELL, DAPHNE  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adoption;Affect;Area;Asthma;attentional control;Behavior;Belief;bilingualism;Caffeine;Caregivers;Child;Child Health;Childhood;Collaborations;Communities;community partners;Data;Development;Dimensions;Disparity population;Education;effectiveness testing;effectiveness/implementation design;eighth grade;Electronics;Enrollment;Environment;Evaluation;evidence base;Exposure to;Family;Feedback;Future;Geographic Locations;Goals;Health;health disparity;High Prevalence;Home;Hybrids;Hygiene;Impairment;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;improved;improvement on sleep;Inadequate Sleep Hygiene;Institution;Intervention;intervention effect;Interview;Investments;junior high school;Knowledge;Language;Latino;Light;Link;Location;Maintenance;Measures;Mediating;Methods;Middle School Student;Modeling;Morbidity - disease rate;Napping;Noise;novel;Obesity;Outcome;Participant;Penetration;Performance;poor health outcome;poor sleep;post intervention;primary outcome;process evaluation;programs;Puerto Rico;Quality Control;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;remote administration;Research;Rhode Island;Risk;Sample Size;Schedule;Schools;secondary outcome;Site;Sleep;Sleep disturbances;sleep health;sleep onset;sleep quality;Spanish/English;Stress;stressor;Students;Surveys;Testing;Time;Training;treatment effect;urban area;urban children;urban school;urban setting;Work

PROJECT_TITLE: A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-K (02)]


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Pain Research;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chikungunya virus (CHIKV)-induced acute and chronic diseases have become a global epidemic. The goal of this project is to define a novel hamster model of CHIKV- induced acute and chronic diseases. Results from this study will increase our understanding of the pathogenesis of CHIKV infection and vertical transmission.

PI_NAMEs: WANG, TIAN  (contact);WANG, ZHONGDE

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Acute;Acute Disease;adaptive immune response;adaptive immunity;Africa;Age;Americas;Animal Model;Antibodies;Arthralgia;Arthritis;Asia;Brain;Cell Culture Techniques;cell mediated immune response;chikungunya;Chikungunya fever;chikungunya infection;Chikungunya virus;Chronic;Chronic Disease;Clinical;cost;CRISPR/Cas technology;cytokine;Development;Disease;disease model;Epidemic;Europe;fetal;Fever;Gene Targeting;Goals;Hamsters;Human;human disease;Immune;Immune response;Immunocompetent;Immunologics;Inbred Mouse;Infection;Inflammation;Injury;Interferon Receptor;Interferons;Investigation;Joints;Knock-out;Lesion;Licensing;Limb structure;lymphoid organ;Measures;Mesocricetus auratus;Modeling;mosquito-borne;mouse model;Mus;Muscle;mutant;Neonatal;nonhuman primate;novel;Organ;Pathogenesis;Patients;Phosphorylation;Placenta;Play;Predisposition;pregnant;Reporting;respiratory infection virus;response;RNA Viruses;Role;Severities;Signal Pathway;Signal Transduction;Stat2 protein;Synovial Fluid;System;T-Lymphocyte;Tanzania;tissue injury;Tissues;transmission process;vaccine access;Vaccines;Vertical Transmission;Viral;Viral Arthritis;Viral Load result;viral RNA;Viremia;Virus;Virus Diseases;Virus Replication;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Novel Hamster Models of Chikungunya Viral Arthritis

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Although clinical evidence demonstrates a unique “obese asthma” endotype that disproportionately affects women and is associated with poor health outcomes (treatment resistance, increased risk of morbidity/mortality), the cellular alterations in the lungs that contribute to worsened lung dysfunction remain poorly understood. This application utilizes a novel model of obese asthma in female mice, that more accurately mimics the human condition to interrogate uniquely proinflammatory profile of innate lymphocytes and how they shape asthma severity. These studies promise to spark innovative solutions for the treatment of obese asthma and to advance our understanding of underexplored cell types in the fields of immunology and metabolism.

PI_NAMEs: DIVANOVIC, SENAD ;LEWKOWICH, IAN PAUL (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;Allergens;Animal Model;antagonist;Asthma;asthma exacerbation;asthmatic;Automobile Driving;Body Weight;C57BL/6 Mouse;Cell Physiology;cell type;Cells;Characteristics;Child;Chronic;chronic inflammatory lung disease;Clinical;Complex;cytokine;Data;Development;Disease;Disproportionately impacts women;Eosinophilia;Exhibits;experimental study;Exploratory/Developmental Grant;Extrinsic asthma;feeding;Female;Functional disorder;functional plasticity;Gene Expression;genetic manipulation;Genetic Models;Genetic Transcription;Glucose Intolerance;granulocyte;Health Expenditures;High Fat Diet;high reward;high risk;Homeostasis;House mice;Human;human disease;human model;IL17 gene;Immune response;Immunity;Immunology;Individual;Inflammation;Inflammatory;inflammatory lung disease;innovation;Insulin Resistance;Link;lipid metabolism;Lung;lung development;Lymphocyte;Lymphoid;Lymphoid Cell;male;Mediator;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Modeling;Morbid Obesity;Morbidity - disease rate;mortality;mouse model;mucosal site;Mucous Membrane;Mus;Nature;neutrophil;novel;Obesity;obesity development;obesity treatment;obesity-associated asthma;Outcome;Pathogenesis;Pathogenicity;Pathologic;Persons;poor health outcome;Population;Production;Public Health;Refractory;Rewards;Risk;Role;Severities;sex;Shapes;single-cell RNA sequencing;small molecule;T-Cell Depletion;T-Lymphocyte;Temperature;Testing;therapy resistant;Thinness;tissue repair;Tissues;Weight Gain

PROJECT_TITLE: Role of Innate Lymphocytes in Obese Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hospital-physician vertical integration - namely, hospitals acquiring independent physician practices, directly employing physicians, or having significant financial ties to physician practices - has been shown to be associated with higher healthcare costs with mixed effects on quality and health services utilization; however, no known study has examined hospital-physician vertical integration in the context of patients with multiple chronic conditions (MCCs), who tend to be costly, high utilizers of health care. By evaluating the association between hospital- physician vertical integration and costs, quality, and health services utilization outcomes for patients with MCCs, this research will fill a critical knowledge gap of how hospital-physician integration has impacted integrated providers’ ability to improve outcomes and manage costs for patients with MCCs.

PI_NAMEs: HARRIS, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: The Effect of Hospital-Physician Vertical Integration on Costs, Quality, and Utilization for Insured Patients with Multiple Chronic Conditions

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Disability Research;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: NARRATIVE  The large unmet need for more robust solutions to limb loss in human patients demands innovative solutions, and nature provides the ultimate inspiration in salamanders, which have limbs similar to human limbs but which completely regenerate following amputation. This project is aimed at understanding how axolotls, a kind of salamander, respond to amputation and create a blastema, a transient structure on the stump necessary for regeneration. We hypothesize axolotls coordinate the activity of tissue-resident progenitor cells, the neuroendrocrine system, and the central nervous system for the initiation of limb regeneration and blastema creation.

PI_NAMEs: WHITED, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adrenal Glands;Adrenergic Agents;Affect;Ambystoma;American;Amputation;Amputees;Anatomy;Antlers;appendage;Applied Research;Articulation;Arts;ATAC-seq;Behavior;Biology;blastema;Brain;Brain region;Breathing;Cardiovascular system;Cell Cycle;Cell Separation;Cell Transplantation;Cells;Central Nervous System;Complex;Cues;Data;Deer;Developmental Biology;Diabetes Mellitus;Digit structure;Disease;Distal;Distant;Engineering;Esthesia;Event;Face;Faculty;flexibility;Foundations;Functional disorder;Future;genome editing;Goals;Growth;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Implant;Injury;innovation;insight;Instruction;Insulin Resistance;Left;Life;limb amputation;limb loss;limb regeneration;Limb structure;Mammals;medical schools;Modeling;Modernization;Molecular;Morphology;Mus;Natural regeneration;Nature;Neurobiology;Neurons;Neurosecretory Systems;new technology;Pathology;patient mobility;Patients;Pattern;Peripheral Nervous System;Pituitary Gland;Pituitary-Adrenal System;Population;Positioning Attribute;Prevalence;Process;progenitor;Proliferating;Prosthesis;psychological distress;regenerative;regenerative biology;Regenerative Medicine;Regenerative response;Research;response;response to injury;restoration;Role;Salamander;Schools;Science;Seasons;sensor;Signal Transduction;single-cell RNA sequencing;Site;Source;stem cell biology;stem cell proliferation;stem cells;Structure;System;technological innovation;Testing;Tetrapoda;Therapeutic;Therapeutic Intervention;tissue regeneration;Tissues;tool;Universities;Work

PROJECT_TITLE: Roles of body-wide injury responses in axolotl limb regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-A (50)]


ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: Project Narrative Founded in 1983, Aga Khan University (AKU) is a private, international, not-for-profit institution whose network of medical centres and hospitals throughout East Africa and Central and South Asia grant unique access to populations not served by any other health organizations in the world. AKU’s health networks offer a unique and timely opportunity: to engage some of the world’s poorest and most vulnerable populations and generate the kind of health data that can drive effective evidence-based interventions and policy that can improve the health and bolster the resiliency of these communities. In order to maximize the potential of AKU’s health networks in support of this kind of advanced research and improve health equity globally, AKU seeks funding to build and sustain research administration capacity both within its own institution and at other institutions across Pakistan.

PI_NAMEs: MOKDAD, ALI H;VIRANI, SALIM S (contact)

PROJECT_TERMS: Address;Administrator;Adoption;Africa;Area;Asia;Award;Budgets;Businesses;Communities;Country;Data;data management;design;Development;Ecosystem;Education;education resources;Educational workshop;Employee;Ensure;Ethics;Event;Evidence based intervention;Faculty;Focus Groups;Funding;Goals;Grant;Health;health data;health equity;health organization;Health Sciences;Hospitals;Human Resources;improved;Income;Infrastructure;Institution;International;Knowledge;Leadership;Manuals;Medical center;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Pakistan;Persons;Policies;Population;Privatization;Procedures;Process;programs;Recommendation;Records;recruit;Reporting;Research;Research Personnel;Research Project Grants;resilience;Resource Sharing;Resources;Strategic Planning;System;Testing;Time;Training;Training and Education;Training Programs;Translating;Universities;University adminstration;Vulnerable Populations;Washington;working group

PROJECT_TITLE: Developing a Supportive Research Administration Ecosystem

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 NKD-D (J2)]


ORG_CITY: COLLEGE PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE (Public Health Relevance) The MPRC promotes research that is central to the NICHD Population Dynamics Branch mission, in areas of demographic research, population and health, and reproductive health and HIV/AIDS research.

PI_NAMEs: RENDALL, MICHAEL S. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;African American;Agriculture;American;Anthropology;Applications Grants;Area;Award;Behavior;behavioral and social science;behavioral health;Biometry;Censuses;Child Rearing;Collaborations;college;Communities;Community Health;Computer software;computing resources;Consultations;Country;Criminology;Data;data access;data enclave;data management;data resource;Destinations;Development;District of Columbia;Economics;Education;Educational workshop;Environment;Environmental Health;Epidemiology;Ethnic Origin;experience;Exposure to;Faculty;Family;forging;Fostering;Funding;Gender;Grant;Health;health disparity;Health Services;HIV/AIDS;Home;Immigrant;Individual;Inequality;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Joints;Kinesiology;Leadership;Life Cycle Stages;Link;Location;Maryland;Mentors;Methodology;Methods;mid-career faculty;migration;Mission;National Institute of Child Health and Human Development;Natural Resources;novel strategies;Outcome;Policies;Population;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Preparation;Process;Productivity;programs;Psychology;public health relevance;Public Health Schools;Public Policy;Race;Reproductive Health;Request for Applications;Research;Research Assistant;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Scientist;Secure;Series;Services;social;Social Change;Social Environment;Sociology;Statistical Computing;statistics;Survey Methodology;Surveys;symposium;time use;Training;Underrepresented Minority;United States National Center for Health Statistics;Universities;virtual;Visit;Washington;web-based tool;Work

PROJECT_TITLE: Maryland Population Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-K (55)]


PROJECT_TERMS: Administrative Efficiency;Administrator;Advertising;Advocate;Applications Grants;Appointment;Award;Businesses;Bylaw;college;Communication;Communities;Data;data centers;data space;Dedications;Development;Educational workshop;Electronic Mail;Electronics;Employee;Equipment;Faculty;Financial Support;flexibility;Floor;follow-up;Foundations;Goals;Grant;Heart;Information Services;innovation;Institution;Laboratories;Leadership;Libraries;Link;Logistics;Maryland;meetings;member;Memory;mid-career faculty;news;Newsletter;Play;Population;Population Research;Preparation;Press Releases;Productivity;programs;Reporting;Research;Research Assistant;research data dissemination;Research Infrastructure;Research Personnel;Reservations;Role;Running;Schools;Scientist;Service provision;Services;Special Event;statistics;Structure;symposium;System;Time;time use;United States National Institutes of Health;Universities;University adminstration;Visit;visiting scholar;web site;Writing

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PARKER, SUSAN W (contact)

PROJECT_TERMS: Address;Area;Behavior;career;Career Choice;career development;Collaborations;college;Communities;COVID-19 pandemic;Data;Development;Discipline;Discrimination;District of Columbia;Economics;Educational workshop;Environment;environmental change;experience;Faculty;Family;Financial Support;Fostering;Foundations;Funding;Funding Agency;Gender;Grant;Health;Immigrant;Individual;Inequality;innovation;Institution;interest;International;Lead;Maryland;Mentors;Methods;metropolitan;mid-career faculty;migration;minority investigator;Mission;National Institute of Child Health and Human Development;Outcome;outreach;Play;Policies;Population;Population Dynamics;population health;Population Research;Population Sciences;Postdoctoral Fellow;Process;Productivity;programs;Race;recruit;Reproductive Health;Research;Research Infrastructure;Research Personnel;Resources;Role;Scholars Program;Schools;Scientist;Series;sexual minority health;social;Social Change;Social Environment;statistics;success;symposium;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;Visit;visiting scholar;Work

PROJECT_TITLE: Development Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: NARRATIVE The Gordon Research Conference (GRC) on the Frontal Cortex was established in 2022 to provide a forum for researchers interested in the prefrontal cortex, related parts of the frontal cortex and their functions across species. The frontal cortex regulates a wide range of behaviors and cognitive functions and is disrupted in numerous psychiatric and neurological diseases, necessitating an integrative, cross-topic platform to advance understanding of this complex brain system. For the 2024 meeting, we have planned a diverse meeting to include trainees and speakers from multiple research perspectives and career stages and have emphasized participation of under-represented groups.

PI_NAMEs: MOORMAN, DAVID E;SHANSKY, REBECCA M (contact)

PROGRAM_OFFICER_NAME: MEZA-CERVERA, TATIANA

PROJECT_TERMS: Affect;Affective;Anatomy;Animal Model;Area;Basic Science;Behavior;Biological Models;Brain;BRAIN initiative;Calcium;career;cell type;Cognition;Cognitive;cognitive control;cognitive function;Collaborations;Communities;Comparative Anatomy;Complex;Computer Analysis;Computer Models;cost;Decision Making;Development;Discipline;Electrophysiology (science);Emerging Technologies;Emotional;Ethnic Origin;executive function;Feedback;Financial Support;frontal lobe;Funding;Gender;Genetic;Geographic Locations;Goals;Human;Image;innovation;interest;Learning;Lesion;Link;meetings;member;Mental disorders;Mentors;microaggression;Mission;Modeling;Molecular;Motivation;Mus;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;Nature;Nervous System Disorder;neural;neuroregulation;neurotechnology;nonhuman primate;novel;optogenetics;Participant;Pharmacology;Physiology;posters;Prefrontal Cortex;Primates;programs;Race;Rattus;recruit;Research;Research Personnel;response;reward processing;Rodent;Rodent Model;Role;Science;Scientist;Senior Scientist;Services;Sex Differences;Shapes;Stereotyping;Structure;substance use;Substance Use Disorder;success;symposium;System;Techniques;Therapeutic;therapeutic target;tool;Translational Research;Underrepresented Populations;United States National Institutes of Health;Vision;Woman

PROJECT_TITLE: 2024 Frontal Cortex Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (G2)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging

PHR: Narrative Intermediate filaments (IFs) are a family of intracellular proteins involved in numerous functions. Mutations in genes encoding IF proteins cause over 100 human diseases that affect major organs, including skin, skeletal muscle, bone, heart, brain, nerves, and the vasculature, as well as aspects of aging. The 2024 Gordon Research Conference on IFs, together with the accompanying Gordon Research Seminar, will bring together scientists from around the world and across the career spectrum to discuss recent discoveries in the field.

PI_NAMEs: WORMAN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Address;Affect;Aging;Area;Basic Science;Biology;Biomedical Engineering;Biomedical Research;Biophysics;Body System;bone;Brain;cancer biomarkers;Cardiomyopathies;Cardiovascular system;career;Cell Physiology;cell type;Cells;Cellular biology;Chronic;Circulation;Clinic;Collaborations;Communities;COVID-19 pandemic;Creativeness;Cytoskeleton;Development;differential expression;Discipline;Disease;Educational workshop;Environment;Family;Fees;Fostering;Functional disorder;Funding;Future;Gene Family;Genes;Genetic;genetic regulatory protein;Goals;graduate student;Growth;Health;Heart;Human;human disease;insight;interest;Intermediate Filament Proteins;Intermediate Filaments;International;lectures;Life;Link;Liver diseases;Mechanics;medical specialties;Medicine;meetings;member;Mentors;Mentorship;Muscular Dystrophies;Mutation;Nanostructures;Nerve;Neurodegenerative Disorders;novel;novel therapeutic intervention;Organ;Participant;Physiological;Postdoctoral Fellow;posters;precision medicine;Premature aging syndrome;programs;Protein Family;Proteins;Public Health;recruit;Request for Applications;Research;Research Personnel;response;Role;Running;Schedule;Scientist;Selection Criteria;sensor;Signal Transduction;Skeletal Muscle;Skeleton;Skin;skin disorder;social;Spain;structural biology;Structural Protein;Students;success;symposium;synergism;Talents;Thinking;Tissues;translational scientist;virtual;Woman

PROJECT_TITLE: 2024 Intermediate Filaments Gordon Research Conference and Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Opioids

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The proposed research is relevant to public health because it will fill a gap in knowledge about neuromodulators and brain regions involved in affiliative, non-sexual, positive social behaviors, which are disrupted by multiple mental health disorders. This project is relevant to NIMH’s mission, as knowledge about basic mechanisms underlying these types of social behaviors is crucial to develop treatments that can restore the positive, affiliative social interactions that are devastated by mental illness.

PI_NAMEs: RITERS, LAUREN V (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: anxiety spectrum disorders;Area;autism spectrum disorder;Behavior;Biological;Brain region;Communication;Complex;Data;Down-Regulation;endogenous opioids;European;Exhibits;Female;Food;Funding;Genes;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Human;Individual Differences;individual responsibility;individuals with autism spectrum disorder;innovation;insight;knock-down;Knockout Mice;Knowledge;male;medial preoptic nucleus;Mental Depression;Mental disorders;metabotropic glutamate receptor 5;metabotropic glutamate receptor type 1;Mission;Modeling;Motivation;mu opioid receptors;N-Methyl-D-Aspartate Receptors;National Institute of Mental Health;neural;neural circuit;neuromechanism;Neuromodulator;neurotransmission;Nucleus Accumbens;Opioid;Partner in relationship;Pharmaceutical Preparations;pharmacologic;Play;postsynaptic;Property;Public Health;Rattus;Receptor Gene;reinforcer;Reporting;Research;Rewards;Rodent;Role;Scaffolding Protein;Site;small hairpin RNA;social;social attachment;Social Behavior;social communication;social deficits;Social Interaction;Songbirds;Sturnus vulgaris;System;Testing;Time;transcriptome sequencing;United States National Institutes of Health;Ventral Tegmental Area;Viral;vocal learning

PROJECT_TITLE: Role of opioid-glutamate interactions in intrinsically rewarded social behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ALBUQUERQUE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Hantavirus disease is a form of zoonotic viral hemorrhagic fever (VHF) that results when humans inhale excreta from hantavirus-infected rodents, with case-fatality rates exceeding 40% for some hantaviruses. In its natural reservoir host, the brown rat, Seoul virus causes asymptomatic, lifelong infection, posing a persistent threat to humans worldwide due to the global rat distribution. This proposal capitalizes on the functional proteomics expertise of the team to identify host-specific interacting partners of Seoul virus proteins that determine resistance to interferon-mediated viral restriction in reservoir host cells, thereby identifying novel effectors to limit viral infection in humans.

PI_NAMEs: KELL, ALISON  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Affinity Chromatography;Andes Virus;antagonist;antiviral immunity;Argentina;Biological Assay;Blood Vessels;Bunyavirales;Canada;Case Fatality Rates;Cells;chemokine;comparative;Complex;cost;Data;Disease;Disease Outbreaks;effective therapy;Endothelial Cells;Ensure;Event;experience;Family;FDA approved;Frequencies;Gene Expression;Genomics;Hantaan virus;Hantavirus;Hantavirus Infections;Hospitalization;Human;human disease;Immune;Immune response;Immune signaling;Immunity;Immunology;immunoregulation;Immunosuppression;Impairment;in vitro Assay;in vivo;infected vector rodent;Infection;Inflammation;Inflammatory;Inhalation;innovation;insight;Interferon Type I;Interferon Type II;Interferons;Knock-out;Knowledge;Laboratories;Maintenance;Mammals;Maps;Mass Spectrum Analysis;Mediating;Methodology;Modeling;Monoclonal Antibodies;Mus;Nature;new therapeutic target;novel;novel virus;particle;Pathogenicity;Population;Positioning Attribute;Predisposition;pressure;prevent;Production;protein complex;protein expression;Proteins;Proteome;Proteomics;Rattus;Rattus norvegicus;Reagent;receptor;Research;Resistance;RNA Viruses;Rodent;Role;Sentinel;Seoul virus;Severity of illness;Shrews;Signal Transduction;Sin Nombre virus;success;Supporting Cell;Survivors;System;Systemic infection;Testing;Therapeutic;Time;Tissues;transmission process;Vaccines;Validation;Viral;Viral Hemorrhagic Fevers;Viral Load result;Viral Proteins;viral RNA;Viremia;Virion;virology;Virus;Virus Diseases;virus host interaction;Virus Replication;Work;Zoonoses

PROJECT_TITLE: Mapping the virus-host interactions that determine interferon resistance of Seoul orthohantavirus

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative There is an urgent unmet need to develop methods to promote limb regeneration after congenital or adult amputation. We have recently discovered that a skeletal stem cell identified by our group has the capacity to promote limb regeneration. We will here determine the functions and mechanisms of this stem cell to orchestrate multi-tissue regenerative responses, with the ultimate goal of harnessing this cell to enable patient limb regeneration.

PI_NAMEs: GREENBLATT, MATTHEW BLAKE (contact);YANG, XU

PROJECT_TERMS: Accounting;Adult;Amniotic Band Syndrome;Amputation;Autologous;blastema;Blood Vessels;bone;Bone callus;bone fracture repair;Bone Regeneration;Cell surface;Cell Therapy;Cell Transplantation;cell type;Cells;Cellularity;Child;Chondrocytes;combat;Data;Development;diabetic;digit regeneration;Digit structure;Distal;Elements;functional restoration;Genetic Transcription;Goals;Growth;Harvest;healing;Human;Implant;implantation;in vivo;in vivo regeneration;Injury;injury and repair;joint formation;Joints;limb amputation;Limb Bud;limb loss;limb regeneration;Limb structure;Literature;Mammals;Mediating;Mediator;Mesenchyme;Methods;Modeling;mouse model;Mus;Natural regeneration;Nature;novel strategies;Organism;Orthopedics;Osteoblasts;Patients;Pattern;Periosteum;Physiological;Population;programs;Prosthesis;Quality of life;reconstruction;regenerative;Regenerative capacity;regenerative cell;Regenerative response;regenerative tissue;repaired;response;restoration;Role;Sarcoma;Signal Transduction;Site;skeletal;skeletal stem cell;Skeleton;Source;stem cells;tissue regeneration;Tissues;transcriptional reprogramming;Transplantation;Traumatic injury;Vascular Diseases;Weight-Bearing state

PROJECT_TITLE: A skeletal stem cell orchestrating limb regeneration


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

PHR: Traumatic brain injury (TBI) is recognized as a risk factor for neurodegenerative diseases, including Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Here, we propose to continue the expansion of the internationally recognized brain bank and clinical data archive, CONNECT-TBI, via a new initiative, TRANSFORM-TBI, which will also explore relationships between TBI and AD/ADRD pathologies as well as their contribution to late clinical outcomes.

PI_NAMEs: LEE, EDWARD BYUNG-HA;SMITH, DOUGLAS HAMILTON (contact);STEWART, WILLIAM

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Adopted;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Archives;Automobile Driving;Brain;Characteristics;chronic traumatic encephalopathy;Clinical;Clinical Data;clinical phenotype;Communities;comorbidity;Complex;Computer software;Country;data archive;data resource;Data Set;Dementia;Democracy;Development;Diagnosis;digital;Environment;Event;Evolution;Explosion;Exposure to;Heterogeneity;Histology;Image;Individual;Injury;innovation;Institution;interest;International;intimate partner violence;Investigation;Link;Mediating;mild traumatic brain injury;Military Personnel;modifiable risk;multidisciplinary;National Institute of Neurological Disorders and Stroke;Natural History;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;Outcome;Pathologic;Pathology;Phase;Pilot Projects;Prevalence;Process;prospective;Publishing;Recording of previous events;Research;Research Methodology;Research Personnel;research study;Resources;Risk Factors;Scanning;Schedule;Secure;Severities;Site;Slide;sociodemographics;Sports;success;Symptoms;tau Proteins;Time;tissue archive;Tissue Banks;Tissues;Traumatic Brain Injury

PROJECT_TITLE: Transdisciplinary Research Accelerating Neuropathology Studies and Facilitating Open Research Methods in TBI (TRANSFORM-TBI)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-O (26)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

PHR: Project Narrative Human Papillomaviruses (HPVs) remain a significant threat to human health, but how HPVs replicate within the infected host cell remains only partially understood. This project will uncover the important functions of DNA- dependent protein kinase, catalytic subunit (DNA-pkcs) along with R-loops in facilitating HPV replication.

PI_NAMEs: TEMPLETON, CONOR  (contact)

PROJECT_TERMS: Ablation;Accounting;Affect;Applied Genetics;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Binding;Cancer Etiology;carcinogenesis;Cell Cycle;Cell Nucleus;Cells;Cellular biology;chromatin immunoprecipitation;Classification;Complementary RNA;Coupled;Data;daughter cell;DNA;DNA analysis;DNA Damage;DNA replication fork;DNA-PKcs;Dominant-Negative Mutation;Down-Regulation;ds-DNA;Elements;Ensure;Enzymes;Episome;Epithelium;Family;Frequencies;G22P1 gene;Gene Expression Profile;Genes;Genetic Techniques;Genetic Transcription;Genome;Genomics;Health;high risk;Homeostasis;HPV negative;HPV positive;Human;Human papilloma virus infection;Human Papillomavirus;Immune;Immunoprecipitation;Individual;Infection;Invaded;keratinocyte;keratinocyte differentiation;Life Cycle Stages;Light;Location;Maintenance;Male Circumcision;Malignant Neoplasms;Mediating;member;mutant;Nonhomologous DNA End Joining;nucleic acid structure;Pathogenesis;Pathway interactions;penis foreskin;Persons;Phase;Phenotype;Phosphorylation;Phosphotransferases;PIK3CG gene;Process;promoter;Proteins;Regulator Genes;Resolution;response;ribonuclease H1;RNA;Role;Set protein;Signaling Protein;Site;small hairpin RNA;small molecule inhibitor;Structure;trafficking;Transcript;Transcription Initiation Site;transcription termination;transcriptome sequencing;tumor;Undifferentiated;United States;Viral;Viral Genes;Viral Proteins;Virion;Virus Replication;wound;XRCC5 gene

PROJECT_TITLE: Uncovering the Roles of DNA-pkcs in Regulating R-loops during HPV Replication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Maintaining the balance between red blood cell (RBC) production and clearance is critical for maintaining proper oxygenation of the body tissues. Unrestrained differentiation of inflammatory hemophagocytes during Plasmodium infection and chronic Toll-like receptor (TLR) signaling can lead to severe anemia. The goal of this proposal is to uncover the role of the anti-inflammatory immunometabolite itaconate in depleting inflammatory hemophagocytes through cell death mediated mechanisms.

PI_NAMEs: LICHAUCO, KATRINA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aconitic Acid;aged;Anemia;Anemia due to Chronic Disorder;Anti-Inflammatory Agents;Attention;Biological Assay;Biotechnology;Blood;Cell Death;Cell Death Induction;Cells;Cessation of life;Chronic;Circulation;Data;Development;Disease;Endosomes;Enzymes;Equilibrium;Erythrocytes;Erythrophagocytosis;experimental study;Fellowship;Future;Genetic;Genetic Transcription;Goals;Histiocytosis haematophagic;Immune;Immunofluorescence Immunologic;Immunologic Techniques;immunoregulation;in vitro Model;in vivo;Infection;Inflammation;Inflammatory;Knock-out;Knowledge;Lead;live cell imaging;Liver;lupus-like;Macrophage;Malaria;malaria infection;malarial anemia;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;monocyte;mouse model;Mus;Myeloid Cells;novel;overexpression;Pathway interactions;Phagocytosis;Phosphorylation;Phosphotransferases;Plasmodium;Plasmodium yoelii;Play;Population;Post-Translational Protein Processing;prevent;Prevention;Process;Production;Proteins;Reactive Oxygen Species;Receptor Signaling;Regulation;Research Personnel;response;RIPK3 gene;Role;Severities;Signal Transduction;Spleen;Splenic Red Pulp;Stimulus;Succinate Dehydrogenase;Testing;tissue oxygenation;Tissues;TLR7 gene;Toll-like receptors;Training;transcription factor;Transgenic Organisms;Work

PROJECT_TITLE: Itaconate mediated control of inflammatory hemophagocyte accumulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative: Overall PUBLIC HEALTH RELEVANCE: The Harvard Chan ERC plays a vital role in the New England region as well as the nation in providing interdisciplinary education and training for graduate-level professions in key disciplines of occupational health and safety. This work is complemented by continuing education and outreach efforts in these key disciplines. The Center produces researchers and practitioners vital to maintaining workplace health and safety.

PI_NAMEs: CHRISTIANI, DAVID C (contact)

PROJECT_TITLE: Harvard TH Chan Education and Research Center for Occupational Safety and Health


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE – JOHNS HOPKINS ERC OVERALL Situated in the largest, most highly ranked school of public health in the world, the multidisciplinary Johns Hopkins Education and Research Center for Occupational Safety and Health prepares occupational safety and health professionals in the areas of research, education, practice, and policy development, and provides outreach and continuing education in occupational safety and health. Since its establishment in 1977, the Johns Hopkins ERC has evolved in response to changing demands in the field, as well as to scientific and technological advances that impact occupational safety and health practice, research, and education, while retaining steadfastly its commitment to an integrated, interdisciplinary approach to training researchers and practitioners. The Center addresses ongoing and emerging issues, thereby building the national capacity to provide care, set policy, design and manage safety and health programs, and conduct research to further the National Occupational Research Agenda and advance the body of knowledge in this field—and as the only ERC in federal region III, which includes Maryland, Washington, D.C., Virginia, West Virginia, Delaware, and Pennsylvania —we are dedicated to meeting regional as well as national and international needs, and our center’s Outreach and Continuing Education efforts serve hundreds of organizations each year within our region alone, including private-sector businesses, nonprofit and academic organizations, local, state, and federal government agencies, and the military.

PI_NAMEs: RAMACHANDRAN, GURUMURTHY  (contact)

PROJECT_TITLE: Johns Hopkins Education and Research Center for Occupational Safety and Health (JHU ERC)


ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative RMCOEH’s training, research training, Continuing Education, and Outreach directly align with the mission and goals of the National Institute of Occupational Safety and Health. The center with this application aims to further its significant positive impact on worker health and safety in the Department of Human Health Services’ Region 8 and beyond.

PI_NAMEs: HEGMANN, KURT  (contact)

PROJECT_TITLE: Rocky Mountain Center for Occupational and Enviromental Health


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_NAME: CROHN'S AND COLITIS FDN OF AMERICA, INC.

PHR: Project Narrative Psychosocial factors and social determinants of health (SDOH) may put African American pediatric and adult patients at a much higher risk for poor outcomes than other populations. Research is needed to delineate which factors play key roles and how to incorporate these findings into effective awareness and educational programming that result in timely IBD diagnosis and management. In the proposed research, we will address this research gap by delineating the key psychosocial factors and SDOH impacting individuals with IBD with a focus on African American adolescents and adults. We will also identify the key barriers and facilitators to health literacy-sensitive care among adult and pediatric IBD patients with a focus on the barriers to African American adolescents and adults. The results from this research will inform the creation of impactful local and nationwide awareness and educational programs for physicians, patients, and caregivers to improve time to diagnose and to receiving management with effective therapy.

PI_NAMEs: CHU, DANIEL I;POLLOCK, JENNIFER S;WINGATE, LAURA DAWN (contact)

PROJECT_TITLE: RFA-DP-23-002, Improving Health Outcomes for Patients with Inflammatory Bowel Disease through Evidence-based Awareness, Referral, and Education Programs


ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This research will 1) comprehensively evaluate the independent impact of social risk factors on the natural history and outcomes of Inflammatory Bowel Disease (IBD) through a prospective epidemiological study and 2) develop a stakeholder-informed, scalable digital health intervention to enhance IBD management and evaluate its effectiveness in improving patient activation and clinical outcomes and reducing disparities through a pragmatic clinical trial. This project also seeks to translate these findings and other evidence into practice through robust patient and professional education, outreach and awareness programs. Taken together, this work will help to better understand and mitigate health disparities in the treatment of IBD, significantly improving clinical outcomes, quality of life, and health equity and directly informing healthcare policy and clinical practice.

PI_NAMEs: BEWTRA, MEENAKSHI ;KAPPELMAN, MICHAEL D (contact);SINGH, SIDDHARTH

PROJECT_TITLE: RFA-DP-23-002, Improving Outcomes and Reducing Disparities for Patients with Inflammatory Bowel Disease through Epidemiology, Enhanced Disease Management, Dissemination, and Education


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Genetic Testing;Genetics;Heart Disease;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Dilated cardiomyopathy of unknown cause (DCM) has mostly a genetic basis, and identifying genetic risk and detecting very early clinical evidence of DCM in at-risk family members holds promise to prevent it. Harnessing emerging innovations in cardiac magnetic resonance (CMR) imaging may be an ideal approach to detect the earliest clinical evidence with great sensitivity. Leveraging an ongoing, clinical and genetic study of hundreds of DCM families, we propose to explore and validate CMR approaches in at-risk family members. If successful, the proposed study would greatly help to assess and manage risk in family members.

PI_NAMEs: HERSHBERGER, RAY E. (contact);KINNAMON, DANIEL DAVIS;ZAREBA, KAROLINA M

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: advanced disease;Affect;African;age group;Angiotensin-Converting Enzyme Inhibitors;Biological;Biology;Budgets;Cardiac;cardiac magnetic resonance imaging;cascade genetic testing;Characteristics;Classification;Clinical;Clinical Research;Data;diagnostic value;Diffuse;Dilatation - action;Dilated Cardiomyopathy;Disease;Early identification;Echocardiography;Enrollment;European;exome sequencing;Family;Family member;Fibrosis;First Degree Relative;Foundations;Functional disorder;Future;Gadolinium;Genes;Genetic;Genetic Risk;Genetic study;Guidelines;Heart failure;high risk;Individual;Infrastructure;inhibitor therapy;innovation;interstitial;Intervention;Knowledge;Left;Left Ventricular Dysfunction;Magnetic Resonance;Maps;Measures;Myocardial;Myocardial tissue;Myocardium;Pathogenicity;Pathway interactions;Patients;Persons;Phenotype;Practice Guidelines;precision medicine;prevent;Primary idiopathic dilated cardiomyopathy;proband;prognostic value;Public Health;Race;rare variant;Recommendation;Recording of previous events;Relative Risks;Risk;Risk Management;Scanning;screening;serial imaging;sex;Site;Specific qualifier value;Structure;Symptoms;Testing;Tissues;Uncertain Risk;Variant;variant of unknown significance;Ventricular;Work

PROJECT_TITLE: Precision Medicine for Dilated Cardiomyopathy-Cardiac Magnetic Resonance to Identify Early Family Phenotypes

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Prevention;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The purpose of this study is to expand measurement-based psychiatric care across 6 early psychosis treatment teams in Minnesota, each providing coordinated specialty care and in total serving 200 individuals per year. We will establish highly reliable measurement-based psychiatric care using state-of-the-art informatics tools, and we will harness the clinical encounter data to perform novel data-driven predictive analyses. We will also perform a research project that will investigate the potential benefits of identifying cognitive functioning and motivated behavior as explicit treatment targets for individuals entering care; and we will study a well-defined 12-week mobile intervention program to address these targets.

PI_NAMEs: MEYER-KALOS, PIPER S.;VINOGRADOV, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Auditory;Belief;Caring;Clinical;Clinical assessments;clinical encounter;clinical research site;Cognition;cognitive function;cognitive training;Coordinated Specialty Care;Data;Data Coordinating Center;Data Pooling;design;Diagnostic;digital;digital health;Disease;duration of untreated psychosis;early psychosis;Early treatment;Evaluation;evidence base;Evidence based intervention;Exercise;experience;Family member;Feedback;first episode psychosis;functional outcomes;Goals;Graph;handheld mobile device;Impaired cognition;Impairment;improved;improved outcome;Individual;Informatics;informatics tool;Intervention;intervention program;Measurement;Measures;Minnesota;mobile application;Monitor;motivated behavior;Motivation;novel;Outcome;Outcome Measure;Patients;Persons;pleasure;post intervention;Practice based research;predictive modeling;Process;Process Assessment;Program Evaluation;Psychiatric therapeutic procedure;Psychoses;Quality of life;Recovery;Research Project Grants;Running;Schizophrenia;Self Efficacy;self-reported depression;Services;Site;social;social cognition;Social Network;Standardization;Structure;Symptoms;Therapeutic;Training;Training Programs;treatment planning;treatment program;trend;Variant;Waiting Lists;Work

PROJECT_TITLE: Targeting Cognition and Motivation in Coordinated Specialty Care for Early Psychosis


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Microbiome;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: While in vitro fertilization (IVF) has increased the likelihood of pregnancy for couples facing infertility, it is unknown why up to 40% of embryo transfers with genetically normal embryos do not result in a pregnancy. Host- microbial interactions in the urogenital tract of both the female and male partner could impact fertility outcome, but the mechanisms responsible are unclear. This project will study the female and male urogenital microenvironment in couples undergoing IVF treatment to identify factors underlying infertility and IVF success.

PI_NAMEs: BRUBAKER, DOUGLAS ;FARR ZUEND, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Antigen-Presenting Cells;Assisted Reproductive Technology;Biological Assay;Biopsy;CCL2 gene;Cells;Cervical;cervicovaginal;Chromosome abnormality;Clinical;cohort;Computer Analysis;conditioning;cost;Coupled;Couples;cytokine;Data;Diagnosis;DNA;DNA Damage;dysbiosis;Ecology;Embryo;Embryo Transfer;Emotional;Endometrial;Enrollment;Environment;failure Implantation;Female;female fertility;Female genitalia;Female infertility;Fertility;Fertilization in Vitro;fitness;Flow Cytometry;Gene Expression Profile;Genetic Screening;Genitourinary system;high dimensionality;Hormonal;host-microbe interactions;Human Chorionic Gonadotropin;IL7 gene;IL8 gene;Immune;Immunology;implantation;improved;Individual;Infertility;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-1 beta;Interleukin-10;Interleukin-6;Knowledge;Live Birth;Machine Learning;male;male fertility;Male Genital Organs;Male Infertility;Men's Role;metabolomics;metaproteomics;microbial;microbiome;microbiome composition;Modeling;Morphology;Motility;Mucous Membrane;multiple omics;natural Blastocyst Implantation;new therapeutic target;novel therapeutic intervention;Oocytes;Outcome;Participant;penis;post pregnancy;predictive modeling;Pregnancy;Pregnancy Rate;Procedures;Process;Production;Recording of previous events;reproductive;Reproductive Health;Research;Research Personnel;Sampling;Seminal;Seminal fluid;single-cell RNA sequencing;Specimen;Sperm Count Procedure;sperm quality;success;Swab;System;Systems Biology;Techniques;Testing;Therapeutic;Time;TNF gene;Training;Tryptophan;tumor-immune system interactions;ultrasound;Unsafe Sex;urogenital tract;Uterus;Vagina;Volatile Fatty Acids;Women's Role;Women's study

PROJECT_TITLE: The role of the female and male reproductive microenvironment in fertility fitness


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The objective of this research proposal is to identify modifiable factors associated with different postoperative respiratory failure (PRF) phenotypes in adults following elective surgery and to utilize this information to develop and deploy a predictive model and electronic health record (EHR)-based probability scoring system and dashboard for PRF. The feasibility of a multisource (e.g., real-time, and historic clinical and biomarker data) probability score, embedded in the EHR, will be demonstrated through successful deployment in a pre-production environment. This work will be described in five papers and will enable me to develop preliminary data for a competitive R01 proposal focused on implementing and evaluating a validated, real-time PRF predictive model in a UC-wide multi-center study.

PI_NAMEs: STOCKING, JACQUELINE C (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Adult;Biochemical;Biochemical Markers;Biological Markers;Calibration;California;Client satisfaction;Clinical;Clinical Markers;clinical predictive model;Creatinine;Critical Care;dashboard;Data;Data Collection;data curation;data modeling;Development;Discrimination;Dose;Elective Surgical Procedures;Electronic Health Record;Enrollment;Environment;Epidemiology;Event;Fluid Balance;Geography;Goals;Grant;Health;Health system;Healthcare;high risk;Hospital Charges;Hospital Mortality;Hospitalization;Hour;improved;Incidence;indexing;Inflammatory;Intervention Studies;Investments;Maps;Mechanical ventilation;Modeling;modifiable risk;Multicenter Studies;Neurologic;Nurses;Operative Surgical Procedures;Paper;patient oriented;patient population;Patient-Focused Outcomes;Patients;Performance;Perioperative;personalized medicine;Phase;Phenotype;Physicians;Positive-Pressure Respiration;Postoperative Period;postoperative recovery;predictive marker;predictive modeling;pressure;Prevention strategy;Preventive;preventive intervention;Probability;Production;programs;Reporting;Research;Research Proposals;Resources;Respiratory Failure;Risk;Risk Adjustment;Risk Reduction;Scientist;Site;socioeconomics;Source;Surgical complication;System;Therapeutic;Tidal Volume;Time;treatment strategy;Universities;ventilation;Ventilator;Weaning;Work

PROJECT_TITLE: Development of a predictive model and electronic health record-based probability scoring system and dashboard for postoperative respiratory failure

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The synthesis, delivery, and precise localization of AMPA-type glutamate receptors (AMPARs) within the postsynaptic membrane is essential for basal synaptic function and plasticity. In order to determine how new receptors are delivered to specific synaptic connections at the appropriate time and abundance in large and geometrically complex cells like neurons, we present the use of a novel tool for visualizing and inducibly manipulating endogenous AMPAR synaptic trafficking.

PI_NAMEs: KAREEMO, DEAN  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Affinity;Antibodies;Architecture;Area;autism spectrum disorder;Brain Diseases;Cell surface;Cells;Complement Receptor;Complex;Data;Dendrites;Dendritic Spines;Effectiveness;Endoplasmic Reticulum;Endosomes;Engineering;Epilepsy;Excitatory Synapse;experimental study;Glutamate Receptor;Glutamates;Golgi Apparatus;Impairment;Individual;Integral Membrane Protein;Label;Learning;Long-Term Potentiation;Mediating;Memory;meter;Molecular;Monoclonal Antibodies;neural;neuronal cell body;Neurons;non-Native;novel;novel strategies;Organelles;overexpression;Pathway interactions;Penetration;Play;postsynaptic;Postsynaptic Membrane;presynaptic;Process;Protein Overexpression;protein transport;Proteins;receptor;Recombinants;Recording of previous events;recruit;Recycling;response;Role;Schizophrenia;Site;stoichiometry;Surface;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;System;Testing;Tetanus Toxin;Time;tool;trafficking;Translational Regulation;Vertebral column;Viral;Visualization;Visualization software;Work

PROJECT_TITLE: Investigating the synaptic trafficking of endogenous AMPARs


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Nutrition

ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE: Alterations in lipid metabolism and transport are linked to the onset and progression of various human diseases including cancer, diabetes, heart disease, and vision disorders. Our studies will contribute to understanding the molecular mechanisms for the action of enzymes and lipid transport proteins implicated in these processes.

PI_NAMEs: AIROLA, MICHAEL VIRGIL (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Anabolism;Binding;Biochemical;Biological;Biological Assay;Cardiovascular Diseases;Carrier Proteins;Cell membrane;cell motility;Cell Proliferation;Complex;Deuterium;Diabetes Mellitus;Diglycerides;Enzymes;extracellular;Fatty acid glycerol esters;Fatty Acids;Foundations;Funding;Goals;Heart Diseases;human disease;Hydrogen;Hydrolysis;improved;insight;insulin sensitivity;interest;Ions;Knowledge;Lecithin;Link;Lipid Biochemistry;lipid metabolism;lipid transfer protein;lipid transport;Lipids;lipine;Lipoproteins;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;Membrane;Metabolism;Molecular;Molecular Conformation;Molecular Mechanisms of Action;Nuclear Envelope;Obesity;pharmacologic;Phosphatidate Phosphatase;Phosphatidic Acid;Phosphatidylinositols;Phospholipase D;Phospholipids;Physiological;Play;Post-Translational Protein Processing;Process;Protein Dephosphorylation;protein function;Protein phosphatase;Proteins;receptor;Regulation;response;Role;Second Messenger Systems;Site;Stimulus;Structure;Substrate Specificity;therapeutic target;trafficking;Triglycerides;Vision Disorders;Work

PROJECT_TITLE: Structure and regulation of lipid metabolism and transport

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative While dysregulation of heterochromatin to leads developmental disorders and contributing significantly to the progression of cancers, inhibiting heterochromatin also augments cancer immunotherapy. Our proposed studies in a genetically tractable model organism will provide important mechanistic insights into heterochromatin assembly, which will aid the development of new treatment strategies.

PI_NAMEs: JIA, SONGTAO  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;cancer immunotherapy;Cell Cycle;Chromatids;Chromatin;Chromatin Structure;Daughter;daughter strand;Deposition;Development;developmental disease;DNA;DNA biosynthesis;Elements;Epigenetic Process;Experimental Models;Fission Yeast;Gene Expression;genetic approach;genome integrity;genomic tools;Goals;Heterochromatin;histone modification;Histones;human disease;in vivo;Inherited;insight;Lysine;Measures;Methylation;Methyltransferase;model organism;Modeling;Modification;novel therapeutic intervention;Peptide Sequence Determination;Phosphorylation;Role;S phase;segregation;tumor progression

PROJECT_TITLE: Mechanism of Heterochromatin Assembly and epigenetic inheritance

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Contraception/Reproduction;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Preeclampsia and (NAFLD) that prospectively population maternal (PE) is a leading cause of maternal morbidity and mortality in the United States there is an urgent ongoing need to identify its risk factors. Nonalcoholic fatty liver disease is the most common liver disease among women and leads to lipid dysregulation may contribute to endothelial cell dysfunction that characterizes PE. This project will evaluate the association between NAFLD and PE in a diverse patient and define relevant NAFLD-associated lipid changes that may contribute to endothelial dysfunction during pregnancy.

PI_NAMEs: KUSHNER, TATYANA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Active Learning;advanced maternal age;adverse pregnancy outcome;Affect;aged;biobank;Biological Markers;Biometry;Black race;Blood Vessels;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career development;Caring;Clinical;Clinical Investigator;Data;Development;Development Plans;Diabetes Mellitus;Discipline of obstetrics;Eicosanoids;Endothelial Cells;endothelial dysfunction;Environment;Enzymes;Epidemiology;epidemiology study;ethnic minority population;Ethnic Origin;Ethnic Population;Functional disorder;Funding;Future;Gestational Diabetes;Goals;Health;Health system;Hepatic;Hepatology;High Prevalence;high risk;Hispanic;Hypertension;Impairment;improved;Incidence;Infant;Inflammation;Infrastructure;Institution;Intervention;Knowledge;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver injury;Longitudinal cohort;male;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Medicaid;Mentorship;Metabolic;Metabolic syndrome;Minority Women;multi-ethnic;newborn adiposity;non-alcoholic fatty liver disease;Obesity;Outcome;Overweight;Pathogenesis;patient oriented;patient population;Patients;Physicians;Polyunsaturated Fatty Acids;Population;Positioning Attribute;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnant Women;Premature Birth;prepregnancy;prevent;prospective;Prospective cohort;Prospective Studies;racial minority population;racial minority women;Recording of previous events;Regulation;reproductive;Research;research and development;Research Design;Research Personnel;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Role;sex;Syndrome;System;systemic inflammatory response;Testing;Training;Translational Research;Underserved Population;United States;Vascular Cell Adhesion Molecule-1;Woman

PROJECT_TITLE: Nonalcoholic fatty liver disease, associated lipidomic changes, and preeclampsia risk

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Suicide;Suicide Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Suicide is the second leading cause of death among youth in the US and has been increasing at an alarming rate among Black youth. Despite the urgent need, we have no interventions with demonstrated effectiveness for Black youth at risk for suicide. With input from a broad range of stakeholders, we propose to develop an integrated intervention, Cognitive Behavioral Therapy for Suicide Prevention plus the Youth-Nominated Support Team, that will address youths’ intrapersonal risk factors and needs for adult support and connectedness.

PI_NAMEs: EWELL FOSTER, CYNTHIA (CINDY)  (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: access disparities;Accident and Emergency department;Acute;Address;Administrator;Adolescent;Adult;Age;American;Assessment tool;Black race;Caring;Cause of Death;Clergy;Clinic;clinical care;Clinical Trials;Cognitive;Cognitive Therapy;Communities;community based participatory research;community collaboration;community partners;Computer Assisted;Congresses;Continuity of Patient Care;Counseling;County;Data;design;Development;Distress;Education;Effectiveness;effectiveness trial;Emergency department visit;emotion dysregulation;Ethnic Population;European;evidence base;Evidence based intervention;Family;feasibility trial;Feeling suicidal;Friends;Health system;help-seeking behavior;high risk;Hospitals;Hybrids;implementation barriers;implementation framework;implementation/effectiveness;improved;Individual;innovation;Institution;Intervention;Lead;Link;Mental Health;Mental Health Services;Michigan;mortality;Outcome;Outpatients;Parents;Pediatric Hospitals;pilot test;Population;Prevention strategy;Procedures;psychosocial;Psychotherapy;Public Health;racial population;Randomized;Recommendation;Reporting;research and development;Research Methodology;Research Personnel;response;Risk;Risk Factors;Sampling;Schools;Self-Injurious Behavior;sobriety;Social support;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide mortality;Suicide prevention;theories;therapy development;Time;Training;United States Substance Abuse and Mental Health Services Administration;Youth

PROJECT_TITLE: Integrating the Youth Nominated Support Team (YST) with CBT for Black Youth with Acute Suicide Risk


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Since self-supervised deep learning as an emerging artificial intelligence method has demonstrated great success in many fields, it is expected to become a powerful method in aiding many biological tasks. This project will develop a self-supervised deep-learning framework for biomedical studies and apply it in anti- CRISPR protein prediction, ion and small ligand binding prediction, single-cell data analyses across different conditions, and beyond. The framework and associated software tools will be helpful for gene editing design, drug development, and disease studies.

PI_NAMEs: XU, DONG  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Address;Amino Acid Sequence;artificial intelligence method;Base Sequence;Bioinformatics;Biological;Biology;Biomedical Research;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Data;Data Analyses;deep learning;deep learning algorithm;design;Development;Disease;Drug Design;drug development;Genes;Human;Information Systems;Ions;Joints;Label;Learning;Ligand Binding;Mainstreaming;Medical;Methods;Modality;Modeling;Molecular Biology;molecular dynamics;multimodal data;multimodal fusion;novel;online resource;open source tool;Paper;Phylogenetic Analysis;Protein Family;protein structure;protein structure prediction;Proteins;Research;Self Perception;self supervised learning;Sequence Analysis;Shapes;software systems;Software Tools;Source;success;supervised learning;System;Techniques;Testing;Training;Trees;trend

PROJECT_TITLE: Multi-view self-supervised deep learning for biological sequences and beyond

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: AMES

ORG_DEPT: CHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because new methods to support basic research and fundamental studies in protein folding and function are expected to open new avenues for therapeutic intervention. The proposed program is relevant to the part of NIH’s mission that pertains to expanding the knowledge base to address the causes, diagnosis, prevention, and cure of human diseases.

PI_NAMEs: VANVELLER, BRETT  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Amino Acids;Basic Science;Binding Proteins;Bioinformatics;Biological Products;Biophysics;Carbon;Chemistry;design;Development;Diagnosis;Drug Design;drug discovery;Drug Interactions;Evaluation;Experimental Designs;Exposure to;functional group;Future;human disease;Hydrogen Bonding;inhibitor;innovation;knowledge base;Methods;Mission;Modification;novel;Peptide Synthesis;Peptides;Perception;Performance;Phase;preservation;Prevention;Procedures;programs;protein aminoacid sequence;protein folding;protein function;Proteins;Public Health;racemization;Reagent;Reporting;Research;scaffold;Side;Site;small molecule;Solid;stereochemistry;Structure;Surveys;targeted treatment;Therapeutic;Therapeutic Intervention;Thioamides;tool;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Peptide backbone modifications to enhance and study protein folding and binding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative Tuberculosis (TB) is a significant public health burden, with one-third of the world's population infected with Mycobacterium tuberculosis (Mtb), the causative agent of TB. Efforts have been made to fight TB by developing better vaccines and new TB drugs; however, these efforts are impeded by the knowledge gap in understanding the immune responses to Mtb with co-infections. The proposed study will investigate how environmental non-tuberculous mycobacteria (NTM), which are endemic in regions with a high burden of TB, impact the development of humoral immunity in the lungs and contribute to TB immunity.

PI_NAMEs: DUTT, TARU S. (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Affect;Affinity;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Affinity;Antigen-Presenting Cells;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Bacille Calmette-Guerin vaccination;BCG Live;Binding;Biogenesis;career;Cells;Clinical;Clonal Expansion;co-infection;Collaborations;Country;Data;Developing Countries;Development;Disease;draining lymph node;drinking water;drug-sensitive;Environment;experience;Exposure to;extensive drug resistance;Extreme drug resistant tuberculosis;fighting;Foundations;Generations;Genetic;Genus Mycobacterium;global health;Grant;Helper-Inducer T-Lymphocyte;Human;Humoral Immunities;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;Immunology;improved;Infection;Inflammatory;insight;Knockout Mice;Knowledge;Lesion;Licensing;Lung;lymph nodes;Mediating;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mus;Mycobacterium avium;Mycobacterium leprae;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;non-tuberculosis mycobacteria;novel therapeutics;opportunistic pathogen;Organ;Pathogenesis;Pathway interactions;Patient Compliance;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Population;Postdoctoral Fellow;prevent;programs;Proteome;Public Health;Pulmonary Tuberculosis;receptor;recruit;Reporting;Research;response;Role;secondary lymphoid organ;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Specificity;Spleen;Stimulus;Stromal Cells;Structure of germinal center of lymph node;Tissues;Training;transcriptomics;Tuberculosis;tuberculosis drugs;tuberculosis immunity;tuberculosis treatment;Tumor Necrosis Factor-Beta;United States Environmental Protection Agency;Vaccinated;Vaccines

PROJECT_TITLE: Non-tuberculous mycobacterium and B cells in the stimulation of ectopic germinal centers and immunological control of pulmonary tuberculosis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Lung cancer is the deadliest form of cancer and is diagnosed by performing biopsies with a bronchoscope; how- ever, this tool is limited in its ability to explore deep into the periphery of the lung, where cancer can remain undetected. This proposal focuses on the design, development, and validation of a novel soft surgical robot to address critical unmet needs within the world of lung cancer. These include increasing the depth of access in peripheral regions and improving navigability within the lungs, enhancing the precision and accuracy of tissue biopsies, and enabling for the first-time rapid diagnosis and simultaneous therapy in a single bronchoscopy pro- cedure to hasten cancer treatment and increase the rate of survival.

PI_NAMEs: RUSSO, SHEILA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Acceleration;Accidents;Address;Affect;Air;Algorithms;Anatomic Models;Anatomy;Area;Biopsy;Biopsy Specimen;blind;Breathing;Bronchi;Bronchial Tree;Bronchoscopes;Bronchoscopy;cancer diagnosis;cancer therapy;cancer type;Cause of Death;Cessation of life;Collaborations;Colon Carcinoma;Computer software;Computer Vision Systems;cost effective;Data;Death Rate;design;Development;Device or Instrument Development;dexterity;Diagnosis;Diagnostic;Diameter;Distal;Drug Delivery Systems;Drug Targeting;Early Diagnosis;Early treatment;Evaluation;experience;experimental study;fabrication;Family suidae;flexibility;Goals;Health Care Costs;image guided;improved;In Vitro;in vitro testing;instrument;Intervention;Intuition;Learning;Lesion;Location;Lung;Lung nodule;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Marketing;Mechanics;Medical Device;miniaturize;Movement;Needles;novel;Operative Surgical Procedures;Patients;Performance;Peripheral;Positioning Attribute;preservation;Procedures;Pulmonology;Radial;rapid diagnosis;Reaction;Recording of previous events;Research;Risk;Robot;robot assistance;robot control;Robotics;Safety;Site;Stroke;success;Survival Rate;System;Technology;Therapeutic;Time;Tissue Sample;tissue trauma;Tissues;tool;tumor growth;United States;Validation;Vision;visual feedback;Visualization;Work

PROJECT_TITLE: Extending Reach, Accuracy, and Therapeutic Capabilities: A Soft Robot for Peripheral Early-Stage Lung Cancer

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_STATE: OH

PHR: PROJECT NARRATIVE This R01 aims to determine the differential impact of flavor and synthetic cooling properties on vaping behavior and toxicant exposure. The proposed study will utilize a comprehensive approach to examine the abuse liability (including the sensory ratings and appeal) of e-liquids with and without the presence of synthetic cooling agents. Findings would immediately inform the evidence base needed to inform FDA rulemaking surrounding the use of synthetic cooling agent additives in EC products.

PI_NAMEs: TACKETT, ALAYNA PAULINE (contact)

PROGRAM_OFFICER_NAME: LEE, YOUN OK

PROJECT_TERMS: abuse liability;addiction liability;Aerosols;aged;Anesthetics;Behavior;Behavioral;behavioral economics;bronchial epithelium;Cicatrix;Complex;craving;Cross-Over Trials;cytotoxicity;Data;Dermal;Devices;Diacetyl;Disease;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Epithelial Cells;Esthesia;evidence base;exposed human population;exposure pathway;exposure route;Exposure to;Eye;Frequencies;Fruit;Genus Mentha;Health;Human;Ice;indexing;Ingestion;Inhalation;Lung;Mainstreaming;Mango - dietary;Marketing;Masks;Measures;Menthol;Methods;Names;Nicotine;Nicotine Dependence;novel;Participant;Property;psychologic;Qualifying;Randomized;Regimen;Research Personnel;Rewards;Safety;satisfaction;Sensory;Single-Blind Study;Tobacco;tobacco regulatory science;Toxic effect;toxicant;Toxicant exposure;Toxicology;uptake;vaper;vaping;Water;Watermelon;Weight;Withdrawal;young adult;Youth

PROJECT_TITLE: The abuse liability, topography and toxicology of ice flavors and non-menthol synthetic cooling agents in e-cigarette products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(56)]


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: NARRATIVE Although all cells have the same collection of genes, what makes them different is which genes are turned on and which are turned off. When genes are inappropriately expressed, cancer can sometimes occur, or the development of an organism can occur improperly. This proposal focuses on understanding links between different steps in turning on a gene, in particular, the relationship between destroying the ﬁnal protein product, making the protein product, and getting rid of intermediate products.

PI_NAMEs: RISSLAND, OLIVIA SELFRIDGE (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Area;Award;Biological;Biological Models;Biology;Cells;Codon Nucleotides;Collection;Cytoplasm;Development;Drosophila genus;Drosophila melanogaster;Embryo;Excision;Gene Expression;Gene Expression Regulation;gene product;Genes;Human;Investigation;Lead;Link;Malignant Neoplasms;Mediating;Molecular;mRNA Decay;mRNA Translation;Organism;Output;Pathway interactions;Philosophy;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Proteins;Reading;Regulation;Regulatory Pathway;Research;RNA-Binding Proteins;Role;Shapes;skills;System;Time;Translation Initiation;Translational Repression;Translations;Work

PROJECT_TITLE: Cytoplasmic mechanisms of gene regulation: intersections and coordination


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The principal goal of our training program is to provide a rigorous, innovative, and multidisciplinary training program on Social Environments and Population Health that integrates research, study, and associated activities. The training program, anchored in the Penn State Dual-Degree Demography Program, the Population Research Institute, and associated departments and programs, has a long history of successfully recruiting promising predoctoral and postdoctoral candidates in the population sciences and placing them in high-impact, research-intensive positions.

PI_NAMEs: ICELAND, JOHN D. (contact);VAN HOOK, JENNIFER

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: population health;Social Environment;Training Programs

PROJECT_TITLE: Training Program in Social Environments and Population Health


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE Cervical cancer is the 4th most common cancer in women worldwide, with over 85% of cases and related deaths occurring in low- and middle-income countries (LMICs). Human immunodeficiency virus (HIV) infection is a known risk factor, with women living with HIV (WLWH) having a 5–8-fold increased risk of developing cervical cancer. The AVANÇO Research Consortium is a collaboration between Mozambique, Brazil and the US to advance novel and affordable technologies for the prevention and diagnosis of cervical cancer among WLWH in LMICs.

PI_NAMEs: BAGNATO, VANDERLEI ;CHIAO, ELIZABETH Y.;KREITCHMANN, REGIS ;LORENZONI, CESALTINA FERREIRA;RICHARDS-KORTUM, REBECCA R.;SCHMELER, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Advanced Development;Africa;Age;AIDS related cancer;AIDS-Related Opportunistic Infections;antiretroviral therapy;Behavioral Sciences;Biomedical Engineering;Brazil;Cancer Etiology;career;Categories;Cervical;Cervical Cancer Screening;Cervical dysplasia;Cessation of life;Chronic;Clinical;co-infection;Collaborations;college;Colposcopes;Communication;comorbidity;cost;Country;Coupled;Development;Diagnosis;Disease;Disparity;Epidemic;Epidemiology;Extramural Activities;Fostering;Funding;girls;Goals;Health;Health Sciences;Histologic;HIV;HIV Infections;Hospitals;Human papilloma virus infection;Human Papilloma Virus Vaccine;Image;imaging platform;Immunosuppression;improved;Incidence;Income;Infrastructure;Institution;International;Joints;Language;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Medicine;member;Mentors;Microscope;Morbidity - disease rate;mortality;Mozambique;multimodality;novel;Optics;overtreatment;pandemic disease;Pathology;performance tests;Persons;Physicians;Pilot Projects;point of care;Portuguese;prevent;Prevention;Prevention approach;programs;Public Health;Publications;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Resource Sharing;Rice;Risk;Risk Factors;Scientist;screening;Technology;Testing;Texas;tool;Triage;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;Viral;Virus Diseases;Vision;Woman;Women's mortality;women's treatment;World Health Organization

PROJECT_TITLE: The AVANÇO Research Consortium: A Mozambique/Brazil/Texas Alliance to advance novel and affordable technologies for the prevention and diagnosis of cervical cancer in women living with HIV


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

PHR: NARRATIVE The Administrative Core (AC) of the AVANÇO Research Consortium will provide scientific oversight, as well as effective management and administration of all activities relating to the two Research Projects, the Developmental Core and the Shared Resource Core. In addition, the AC will coordinate interactions with the External Advisory Panel (EAP), the Community Advisory Boards (CAB) and the National Cancer Institute (NCI).The AC will actively work to communicate and disseminate information amongst study investigators, provide organizational, scientific, and budgetary oversight, facilitate collaborations, coordinate meetings and prepare reports throughout the life of the grant.

PI_NAMEs: SCHMELER, KATHLEEN  (contact)

PROJECT_TERMS: Address;Advanced Development;AIDS related cancer;Behavioral Sciences;Biomedical Engineering;Brazil;Cancer Center;Cancer Research Project;career;Categories;Cervical Cancer Screening;Cervical dysplasia;Clinical;co-infection;Collaborations;Communication;community advisory board;comorbidity;cost;Country;Data;Development;Diagnosis;Ensure;Epidemiology;Extramural Activities;Funding;Goals;Grant;Health Sciences;HIV;HIV Infections;HIV/AIDS;Hospitals;Individual;Infrastructure;Institution;Leadership;Life;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;meetings;Mentors;Monitor;Mozambique;National Cancer Advisory Board;National Cancer Institute;novel;Pathology;Persons;Pilot Projects;Prevention;Prevention approach;programs;Recording of previous events;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Resource Sharing;Rice;Risk;Risk Factors;Site;Specimen;Structure;success;Technology;Texas;United States National Institutes of Health;Universities;virtual;Vision;Woman;women's treatment;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT 1 NARRATIVE There is an urgent need to develop novel, low-cost and technologically feasible approaches for cervical screening, diagnosis, and treatment in a single visit. The overall goal of Project 1 is to optimize and evaluate the Multimodal Mobile Colposcope (MMC) for a sensitive and specific diagnostic triage test for women living with HIV (WLWH) who screen positive for cervical cancer. The study will be performed in Mozambique and Brazil where the prevalence of cervical cancer in WLWH is high.

PI_NAMEs: KREITCHMANN, REGIS  (contact)

PROJECT_TERMS: Ablation;accurate diagnosis;Acetic Acids;Address;Advanced Development;AIDS related cancer;Algorithmic Analysis;Artificial Intelligence;automated image analysis;Behavioral Sciences;Biomedical Engineering;Biopsy;Brazil;career;Categories;Cervical;cervical biopsy;cervical cancer prevention;Cervical Cancer Screening;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Cessation of life;Characteristics;Clinical;co-infection;Cold Therapy;Collaborations;Colposcopes;Colposcopy;comorbidity;cost;Country;Cytology;design;Detection;Development;Devices;Diagnosis;Diagnostic;Early Diagnosis;Early treatment;El Salvador;Epidemiology;follow-up;formative assessment;Funding;Goals;Guidelines;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;HPV positive;HPV screening;Human Papillomavirus;Image;Image Analysis;image archival system;Incidence;Infrastructure;Institution;Instruction;Lesion;Libraries;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;medically underserved;Mentors;microendoscope;Modality;Modeling;Mozambique;multimodality;novel;Optical Biopsy;overtreatment;Pathology;Patients;Performance;Pilot Projects;point of care;Predictive Value;premalignant;Prevalence;Prevention;Prevention approach;programs;prospective;Provider;Recommendation;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Resolution;Resource Sharing;Resource-limited setting;Resources;Risk;Risk Factors;screening;Sensitivity and Specificity;Services;skills;Specificity;Speed;standard of care;Technology;Testing;Texas;Time;Training;treatment program;Triage;underserved area;United States National Institutes of Health;usability;user centered design;Virus Diseases;Vision;Visit;Visual;Woman;women's treatment;World Health Organization

PROJECT_TITLE: Project 1


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE OTULIN is a ubiquitously expressed protein critical for immune homeostasis. The proposed research will investigate how post-translational modifications of OTULIN mediate signaling cascades in keratinocytes, and how aberrant signaling due to a novel mutation leads to development of pyoderma gangrenosum in patients.

PI_NAMEs: GIL, HWI (DEBORAH) M (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Affect;Affinity;Amino Acids;Apoptosis;Apoptotic;autoinflammatory;Autophagocytosis;Bar Codes;Binding;Binding Sites;CASP8 gene;Catalytic Domain;Cell Culture Techniques;Cell Death;Cell Death Signaling Process;cell type;Cells;Childhood;Clinical;clinical phenotype;Co-Immunoprecipitations;Color;Complex;Computing Methodologies;congenital immunodeficiency;CRISPR/Cas technology;cytokine therapy;Defect;Development;DNA Damage;DNA Sequence Alteration;Enzymes;Equilibrium;Excision;exome sequencing;experimental study;Flow Cytometry;Genetic Diseases;Germ Lines;Germ-Line Mutation;Heterodimerization;Homeostasis;Human;human disease;Immune;Immune signaling;Immune system;Immunity;Immunologist;In Vitro;Infection;Inflammasome;Inflammation;inhibitor;inorganic phosphate;Interferons;keratinocyte;Knock-out;Maintenance;Mediating;Mendelian disorder;Methods;Missense Mutation;Mitosis;Modification;Molecular;Mus;Mutation;Nature;Necrosis;neutrophil;novel;Pathway interactions;Patients;Phenotype;Phosphorylation;Play;Post-Translational Protein Processing;Predisposition;prevent;programs;protein complex;Proteins;Proteome;Pyoderma Gangrenosum;Qualifying;rare genetic disorder;Recurrence;Reporting;Research;Resources;response;retroviral transduction;RIPK1 gene;RIPK3 gene;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;skin disorder;Specificity;Stable Isotope Labeling;Symptoms;Syndrome;System;Techniques;Tertiary Protein Structure;Testing;therapeutic target;Tumor Necrosis Factor Receptor;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;Western Blotting

PROJECT_TITLE: A novel genetic mutation reveals the molecular and cellular mechanisms of severe recurrent skin inflammation