NIH_SPENDING_CATS: Hematology;Neurosciences;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Iron deficiency suppresses red cell production by the bone marrow, leading to several types of human anemia, including anemia associated with kidney disease. Better understanding of the mechanism for this marrow suppression is needed to improve monitoring and treatment of these conditions. We have recently discovered new, unanticipated components of this mechanism that involve factors previously associated with neural function, -synuclein and dopamine. Delineating the role of these factors in anemia development will enable development of novel treatment strategies.

PI_NAMEs: GOLDFARB, ADAM N. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Affect;alpha synuclein;Anemia;Biological Models;Blood donor;Blood Platelets;Bone Marrow;Calibration;Cell Count;Data Set;deprivation;Development;Diet;dietary control;Dopamine;dosage;Dose;Erythrocytes;Erythroid;Erythropoiesis;Erythropoietin;Experimental Models;experimental study;Frequencies;Future;gain of function;Growth;Half-Life;Hematology;Heme;hepcidin;Heterogeneity;Human;human stem cells;improved;In Vitro;in vivo;in vivo Model;indexing;Individual;inter-individual variation;Intravenous;Iron;iron deficiency;Iron deficiency anemia;Kidney Diseases;Kidney Failure;Knockout Mice;loss of function;Marrow;metabolomics;Mining;Monitor;mouse model;Mus;neural;Neurophysiology - biologic function;neurotransmitter release;novel;novel therapeutic intervention;Nutrition Disorders;Pathway interactions;Patients;Phenotype;Polycythemia Vera;Population;Production;progenitor;protein transport;Proteins;Regulation;Regulator Genes;response;Role;self assembly;Serum;synuclein;targeted treatment;treatment strategy;Up-Regulation;Variant;Venous blood sampling

PROJECT_TITLE: α-Synuclein Regulation of the Erythroid Iron Restriction Response

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cooley's Anemia;Digestive Diseases;Hematology;Kidney Disease;Liver Disease;Nutrition;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NUTRITION

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Iron is an essential nutrient, but it can be toxic in conditions of iron overload. This project will investigate potential therapies for iron overload and define how various iron transport proteins function in the kidney. This research may ultimately lead to new strategies to mitigate iron overload and iron-related kidney pathologies.

PI_NAMEs: KNUTSON, MITCHELL D (contact)

PROJECT_TERMS: absorption;Acinar Cell;Acute Renal Failure with Renal Papillary Necrosis;Adjuvant Therapy;Adolescent;Adverse effects;Affect;Albumins;Antisense Oligonucleotides;apical membrane;Appearance;Award;beta Thalassemia;Binding;Blood Transfusion;Brain;Cardiac;Cardiac Myocytes;Cardiomyopathies;Carrier Proteins;Carrying Capacities;Cause of Death;Cells;Chronic Kidney Failure;Clinical;clinically significant;Cooley's anemia;Data;Diabetes Mellitus;Diabetic Nephropathy;Dietary Iron;Disease;divalent metal;Endocrine;Epithelial Cells;Excretory function;Exhibits;Family;Funding;Grant;Health;Heart;Heart failure;Hematological Disease;Hemochromatosis;Hepatic;Hepatocyte;hepcidin;Hereditary Disease;Hereditary hemochromatosis;HFE2 gene;Homeostasis;Hormones;Human;in vivo;Individual;Inherited;Ions;Iron;Iron Chelating Agents;Iron Chelation;iron deficiency;iron metabolism;Iron Overload;Kidney;Knock-out;Knockout Mice;Knowledge;Liver;Liver diseases;Lung;Mediating;member;Membrane Proteins;Membrane Transport Proteins;Metals;Modeling;Molecular;mouse model;Mus;Nephrons;novel;Nutrient;Oral;Pancreas;Pathology;pharmacologic;Plasma;Play;Population;prevent;protein function;protein metabolism;protein transport;Publishing;Radiolabeled;Recycling;Regulation;Renal tubule structure;Research;response;Risk;Role;Serum;Testing;TFRC gene;thalassemia intermedia;Therapeutic;Time;Tissues;Transferrin;uptake;urinary;ZIP protein

PROJECT_TITLE: ZIP Proteins and Iron Metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Endocannabinoid System Research;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: CITY COLLEGE OF NEW YORK

ORG_STATE: NY

PHR: Animal studies have demonstrated that the regulation of food intake requires articulation among endogenous cannabinoids (ECs), fatty acid-binding proteins (FABPs), and a peroxisome proliferator- activated nuclear receptor (PPARa), but the macromolecular basis for appetite, satiety, and obesity is poorly understood. This project will probe the solution-state macromolecular structure and function of EC- FABP, EC-PPAR, and FABP-EC-PPAR complexes in vitro at near-physiological concentrations, determining affinities, metabolic fates, molecular binding interfaces, and conformational changes to test proposed mechanisms of EC metabolic signaling. Working as a team with research trainees, our work will help to understand health risks and design future therapies for heart disease, autoimmune disorders, and type-2 diabetes.

PI_NAMEs: STARK, RUTH E. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Abbreviations;Address;Affinity;Amides;Animal Model;Animals;Appetite Regulation;Applications Grants;Articulation;Autoimmune Diseases;Binding;Binding Proteins;Binding Sites;Biological Assay;Biophysics;career;Cell Nucleus;Chemicals;Chimera organism;Complex;design;Desire for food;Diffusion;Dissociation;Drug Design;Drug Modulation;endocannabinoid signaling;Endocannabinoids;Enterocytes;Enzymes;Esters;Exhibits;experimental study;fatty acid amide hydrolase;fatty acid-binding proteins;Fatty Acids;Fluorescence;Food Intake Regulation;Future;Genetic Transcription;Glycerol;Health;heart disease risk;Heart Diseases;Human;Hydrophobicity;In Vitro;in vitro testing;Inflammation;Intestines;Knock-out;Knockout Mice;Ligand Binding;Ligand Binding Domain;Ligands;Lipase;Liver;Measures;Mediating;member;Metabolic;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;Monitor;Mus;neuroprotection;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;Outcome;Pain;Pattern;Peroxisome Proliferator-Activated Receptors;Peroxisome Proliferators;Phenotype;Physiological;preference;pressure;programs;Protein Binding Domain;protein complex;protein protein interaction;Proteins;receptor binding;recruit;Regulation;Relaxation;Research;Risk;Role;Satiation;Signal Transduction;Signaling Molecule;Site;Surface Plasmon Resonance;Testing;Thermodynamics;Thinness;thyroid hormone receptor associated protein 220;Titrations;Underrepresented Populations;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In this Supplement Project, specialized C-13 phantoms critical for hardware and methods testing will be optimized for dissemination to the rapidly expanding academic-industry MR molecular imaging community including MR scanner & coil vendors to improve multisite research studies and assist in the development of new methods and in order to advance this powerful emerging molecular MRI approach.

PI_NAMEs: VIGNERON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 2,4-Dinitrophenol;3-Dimensional;Abdomen;Administrative Supplement;Alzheimer's Disease;Anatomy;Automobile Driving;bone;Brain;Brain Diseases;Calibration;Cancer Detection;Carbon;Chemicals;Chemistry;Clinical;Communities;Data;Data Analyses;design;design and construction;detector;Development;Documentation;Educational workshop;Eligibility Determination;Evaluation;Extramural Activities;fabrication;Feedback;fiberglass;Formulation;Funding;Future;Geometry;Glass;Head;Housing;Human;Image;imaging approach;imaging modality;Imaging Phantoms;improved;Industry;Instruction;instrumentation;interest;Libraries;Liver diseases;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Imaging;metabolic imaging;Methodology;Methods;Molecular;molecular imaging;multi-site trial;Multiple Sclerosis;National Institute of Biomedical Imaging and Bioengineering;Neck;new technology;novel;parent grant;Pelvic Cancer;Pelvic lymph node group;Pelvis;Performance;perfusion imaging;Preparation;Procedures;Property;Prostate;Publishing;Pyruvate;Radiology Specialty;Reagent;reconstruction;Relaxation;Research;Research Personnel;Research Project Grants;research study;Resistance;Resources;RF coil;Scanning;Shapes;Signal Transduction;Site;Source;Structure;Technology;technology development;Test Result;Testing;Training;Traumatic Brain Injury;treatment response;tumor;Validation;Vendor;Visualization;web site;Work

PROJECT_TITLE: Administrative Supplement for the Optimization, Calibration, and Dissemination of Carbon-13 Imaging Phantoms


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE We propose to develop Rabies Barcode Interaction Detection followed by sequencing (RaBID-seq), a high- throughput, scalable technology to map the brain-wide monosynaptic inputs to thousand or even millions of neurons in a single animal. We will improve the experimental scalability of RaBID-seq, benchmark RaBID-seq connectivity against gold-standard techniques for assessment of synaptic connectivity, and develop new compu- tational tools to infer monosynaptic wiring from barcoded viral datasets. This new technology will transform our ability to apply brain-wide circuit mapping at scale with synaptic resolution and to identify the transcriptomic cell type of each mapped pre- and post-synaptic neuron.

PI_NAMEs: TOLIAS, ANDREAS  (contact);ZADOR, ANTHONY M

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Acceleration;Algorithms;Anatomy;Animals;Area;area striata;Bar Codes;Behavior;Benchmarking;Brain;Brain Mapping;cell type;Cells;Cognition;computerized tools;connectome;cost;cost effective;Data;Data Set;Detection;Disease;DNA sequencing;Event;experimental study;Face;graph neural network;Human;improved;in silico;In Vitro;in vivo;Infection;Label;Libraries;life span;Link;Location;Maps;Measurement;Measures;Methods;Molecular;Molecular Profiling;motor control;multimodality;Mus;Neurons;new technology;patch clamp;patch sequencing;Perception;Physiological;Physiology;postsynaptic neurons;presynaptic neurons;Production;Publishing;Rabies;Rabies virus;rabies virus barcoding;reconstruction;Resolution;Resources;sex;single-cell RNA sequencing;Slice;Specificity;Synapses;Techniques;Technology;Testing;tool;Toxic effect;transcriptome;transcriptomic profiling;transcriptomics;Variant;Viral

PROJECT_TITLE: BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: NARRATIVE Diabetic foot ulceration is a devastating complication of diabetes that compromises the quality of life, increases risks for lower extremity amputations and further increases risk of death. The main aim is to develop a proteomics biomarker signature prognostic for diabetic wound healing and initiate the determination of its clinical utility. These advances will offer long-term potential for accelerating prognostication tools and biomarker-guided drug development strategies in this field.

PI_NAMEs: NIEWCZAS, MONIKA ANNA;VEVES, ARISTIDIS  (contact)

PROGRAM_OFFICER_NAME: JONES, TERESA L Z

PROJECT_TERMS: Acceleration;Address;Amputation;Basic Science;beta catenin;Biological Markers;Biological Process;biomarker panel;biomarker signature;Biometry;candidate marker;Carboxypeptidase;Cell Adhesion Molecules;cell type;Clinical;Clinical Research;clinical trial enrollment;cohort;Complex;Complications of Diabetes Mellitus;cross reactivity;Data Correlations;detection method;Development;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;diabetic wound healing;Discrimination;Disease;drug development;Elasticity;high risk;Immunoassay;Impaired wound healing;Individual;Inflammatory;interest;Knowledge;Logistic Models;Logistic Regressions;Lower Extremity;Machine Learning;machine learning method;Measurement;Methods;model building;Modeling;mortality risk;Outcome;Pathway Analysis;Pathway interactions;Performance;Phase;Phenotype;Predictive Value;prognostic;Prognostic Marker;prognostic signature;prognostication;prospective;Prospective cohort;protein biomarkers;Proteins;Proteome;Proteomics;Public Health;Quality of life;random forest;Reporting;Reproducibility;research clinical testing;Research Personnel;Risk;Role;single-cell RNA sequencing;Specificity;statistics;support tools;Target Populations;targeted biomarker;Testing;tool;transcription factor;Translational Research;Validation;Work;wound healing

PROJECT_TITLE: Proteomic Biomarkers Prognostic for Diabetic Wound Healing


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Genetics;Prevention;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Narrative Diabetic foot ulcers (DFUs) are a devastating complication of diabetes and represent a major risk factor for amputation of the affected foot. This proposal will non-invasively measure small RNAs in the urine of patients with DFUs and study their ability to predict early which ulcers are unlikely to heal with standard DFU treatments. Results of this project will allow clinicians to promptly identify hard-to-heal DFUs that warrant early intensive therapies, increasing the likelihood of ulcer closure and minimizing pain and risks of serious complications from a chronically open wound.

PI_NAMEs: STONE, RIVKA C. (contact);TOMIC-CANIC, MARJANA

PROJECT_TERMS: Affect;Amputation;Area;Biological Assay;Biological Markers;biomarker panel;biomarker validation;candidate marker;Chronic;chronic ulcer;circulating microRNA;Clinical;clinical implementation;Clinical Management;cohort;Complications of Diabetes Mellitus;cost effective;Custom;Data;data reduction;Death Rate;design;Detection;Development;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;disability;Enrollment;foot;Funding;Funding Mechanisms;healing;improved;Infrastructure;Intervention;Laboratories;Measures;meetings;Methods;microRNA biomarkers;MicroRNAs;miRNA expression profiling;Modeling;Monitor;Morbidity - disease rate;mortality;nano-string;National Institute of Diabetes and Digestive and Kidney Diseases;open wound;Outcome;Pain;participant enrollment;Patients;Phase;Physicians;point of care;predictive modeling;Predictive Value;prognostic;Prognostic Marker;prognostic model;prospective;Prospective cohort;Protocols documentation;Qualifying;Quality of life;Regression Analysis;Reproducibility;response;Risk;Risk Factors;ROC Curve;Running;Sampling;Scientist;Small RNA;Specificity;standard of care;Systemic disease;Testing;Training;treatment response;Ulcer;urinary;Urine;Validation;wound closure

PROJECT_TITLE: Circulating urinary microRNAs as systemic biomarkers of healing outcomes in diabetic foot ulcers


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Machine Learning and Artificial Intelligence;Microbiome;Wound Healing and Care

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative/Public Health Statement Diabetic foot ulcers are a major complication of diabetes leading to an increased risk of lower extremity amputation and death. A major hurdle to the development of new therapies for diabetic foot ulcers is the lack of biomarkers to predict healing and response to treatment. The proposed work will developed a multi-panel biomarker assay based on the wound microbiome to predict healing outcomes.

PI_NAMEs: BRENNAN, MEGHAN  (contact);KALAN, LINDSAY ROBYN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Agreement;American;Amputation;Anaerobic Bacteria;Antibiotic Resistance;Bacteria;base;Beds;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Calibration;Candidate Disease Gene;candidate marker;Cessation of life;Classification;Clinical;Clinical Data;clinical implementation;clinical trial readiness;cohort;Collection;Communities;Complex;Complications of Diabetes Mellitus;Cross-Sectional Studies;Data;Data Coordinating Center;Death Rate;design;Detection;detection method;Development;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diagnostic assay;DNA;Engineering;Exhibits;Genes;Genetic Markers;Genetic Transcription;Goals;healing;Impaired healing;Infectious Agent;Limb Salvage;Limb structure;Longitudinal Studies;Lower Extremity;Machine Learning;machine learning algorithm;Measurement;Measures;Metabolic;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbial community;microbiome;microbiome analysis;microbiome research;Modeling;Molecular;molecular diagnostics;Monitor;multi-site trial;multiplex assay;non-healing wounds;novel;novel therapeutics;Operating Rooms;Organism;Outcome;pathogen;Pathway interactions;Patients;permissiveness;Phase;Population;predictive marker;preservation;Process;prognostic;prospective;Public Health;Publishing;Resolution;Ribosomal RNA;Risk;RNA;sample collection;Sampling;Shotguns;Site;Skin;Specificity;Swab;targeted biomarker;Taxonomy;Techniques;Testing;Therapeutic;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;treatment response;Ulcer;United States National Institutes of Health;Virulence Factors;virulence gene;Visit;Work;wound;wound environment;wound healing

PROJECT_TITLE: Microbiome Based Biomarkers of Wound Healing


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ROCKVILLE

ORG_NAME: BIOQUAL, INC.

ORG_STATE: MD

PI_NAMEs: ANDERSEN, HANNE  (contact)

PROJECT_TERMS: Advanced Development;AIDS Vaccines;Award;Clinical;Complement;Contracts;Development;Evaluation Studies;Funding;Grant;HIV vaccine;Immunotherapy;in vivo;Investigator-Initiated Research;Local Microbicides;Macaca mulatta;Modality;Mucous Membrane;National Institute of Allergy and Infectious Disease;nonhuman primate;p53-binding protein 1;pre-clinical;preclinical evaluation;preclinical study;Prevention;Prevention strategy;programs;Research Personnel;Resources;Route;simian human immunodeficiency virus;SIV;Titrations;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Research;Vaccines;Virus

PROJECT_TITLE: In Vivo SHIV/SIV Titration via Mucosal Route in Indian-origin Rhesus Macaques


NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: PULENDRAN, BALI  (contact)

PROJECT_TERMS: adaptive immune response;Adjuvant;Antigens;clinically relevant;COVID-19 vaccine;Data Analyses;data management;Fingerprint;Goals;Human;Immune;Immunologics;Innate Immune Response;Mus;Organoids;programs;Side;Tissues;Tonsil;Vaccines;Work

PROJECT_TITLE: ADJUVANT COMPARISON AND CHARACTERIZATION


PROJECT_TERMS: Adjuvant;Antibody Response;Antigens;clinically relevant;Fingerprint;Goals;HIV;HIV envelope protein;HIV vaccine;Immune;Immune response;Immunologics;Infection;Learning;Mucous Membrane;neutralizing antibody;nonhuman primate;programs;Side;Tissues;vaccine development;Vaccines;Work

PROJECT_TITLE: Adjuvant Comparison and Characterization (HIV)


PROJECT_TERMS: adaptive immune response;Adjuvant;Allergens;Allergic Disease;Animal Model;Animals;Antigens;Autoimmune Diseases;Basic Science;Cells;clinically relevant;Collaborations;Communicable Diseases;Communities;Contractor;Data;data management;Development;Disease;Disease Outcome;End Point Assay;Fingerprint;Future;Goals;Human;Immune;Immunity;Immunologics;Innate Immune Response;Measures;National Institute of Allergy and Infectious Disease;novel vaccines;pathogen;programs;Protocols documentation;research and development;Side;Site;Standardization;Tissues;vaccine development;Vaccines;Work


NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Diabetes affects over 37 million people in the US, with 90% having type 2 diabetes (T2D). Our overarching objective is to unravel the significance of ER stress in β-cell survival and function under metabolic stress caused by obesity, aging, and lifestyle changes. This research is crucial in the fight against diabetes.

PI_NAMEs: DENG, YINGFENG  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Ablation;Affect;Aging;Animals;Apoptosis;Architecture;arm;ATAC-seq;ATF6 gene;Beta Cell;Binding Proteins;Biological Assay;Biological Process;Blindness;Blood Glucose;Breeding;Bromodeoxyuridine;Budgets;C-Peptide;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Chronic;Chronic Disease;cohort;Conditioned Reflex;cost;CRISPR/Cas technology;Custom;Data;Data Set;design;Deterioration;Diabetes Mellitus;diabetic;DNA Nucleotidylexotransferase;Doxycycline;driving force;Endoplasmic Reticulum;endoplasmic reticulum stress;Epidemic;Euthanasia;experience;experimental study;Fasting;feeding;Female;fighting;Functional disorder;Funding;gene editing technology;Gene Targeting;Genetic;Genetic Transcription;Genotype;Glucose;glucose tolerance;Goals;Hematoxylin and Eosin Staining Method;Homeostasis;Hyperglycemia;Image;imaging approach;Immunofluorescence Immunologic;In Vitro;in vivo;inducible Cre;Insulin;Insulin Resistance;insulin secretion;islet;Islet Cell;Islets of Langerhans;Kidney Failure;Knockout Mice;Knowledge;Label;Left;Length;Life Style;limb amputation;loss of function;Lower Extremity;male;Mammals;Measurement;Mediating;Messenger RNA;metabolic phenotype;Metabolic stress;misfolded protein;Modeling;Molecular;mouse model;Mus;mutant mouse model;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;OGTT;overexpression;Pathologic;Persons;Prediabetes syndrome;prevent;Process;Production;proliferation potential;Protein Biosynthesis;Proteins;Regulation;Research;response;RNA;RNA Splicing;Role;Series;Sex Differences;Signal Pathway;Stroke;Structure of beta Cell of islet;Therapeutic Intervention;therapeutically effective;transcriptomics;Transducers;translational potential;Validation

PROJECT_TITLE: Role of UPR transducer Xbp1 in Pancreatic Beta Cell Survival and Function under Metabolic Stress

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a 5-year survival rate ~10% and is predicted to become the second deadliest cancer within the next 10 years. Epigenetic changes regulating gene expression have become a focus of intense research to help in the development of new treatment for this dismal condition. This proposal will investigate the role of nuclear myosins in chromatin organization leading epigenetic silencing of gene expression during PDAC transformation.

PI_NAMEs: PEASE, DAVID R (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Binding;Biochemical;Biological;Cancer Biology;Cell membrane;cellular imaging;ChIP-seq;Chromatin;conditional mutant;Confocal Microscopy;Data;Development;Disease;DNA Sequence Alteration;Down-Regulation;druggable target;effective therapy;Enhancers;Epigenetic Process;epigenetic silencing;epigenomics;Event;experimental study;Foundations;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Engineering;Genome;Goals;Golgi Apparatus;Growth;Growth and Development function;Heterochromatin;immunocytochemistry;in vitro Model;in vivo;insight;Investigation;knock-down;KRAS oncogenesis;KRAS2 gene;Lamin Type A;Lead;Lesion;live cell imaging;loss of function;Lysine;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Mutation;Myosin ATPase;neoplastic;novel;Nuclear;Nuclear Lamina;Oncogenes;Oncogenic;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Peptide Initiation Factors;Phase;Play;Positioning Attribute;Postdoctoral Fellow;Process;programs;protein protein interaction;Proteins;Regulation;Research;Role;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Survival Rate;Testing;therapeutic target;Time;Training;Transcriptional Regulation;transcriptome sequencing;transcriptomics;tumor;Walking

PROJECT_TITLE: Mechanisms of gene expression regulation in pancreatic cancer


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: San Carlos

ORG_NAME: GLYTR THERAPEUTICS, INC.

PHR: Project Narrative Directing the immune system to kill cancer cells is a highly potent way of treating cancer. Abnormal addition of carbohydrates to proteins is a near universal feature of cancer, however current immunotherapies cannot readily target these. Here we propose to further develop a novel technology that directs immune cells to kill cancer cells based on expression of altered carbohydrates.

PI_NAMEs: DEMETRIOU, MICHAEL  (contact);ZHOU, RAYMOND WENHOU

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Address;Antibodies;Antigen Targeting;Antigens;B-Cell Neoplasm;B-Lymphocytes;bi-specific T cell engager;Binding;Binding Proteins;Biological Assay;Bispecific Antibodies;Bite;cancer cell;Cancer Center;cancer immunotherapy;Cancer Patient;Carbohydrates;CD3 Antigens;Cell surface;Cell Surface Proteins;Cells;Clinical Trials;Combined Modality Therapy;Complex;cost;CTLA4 gene;Data;Detection;Development;Disease;Disease Progression;Dose;driver mutation;Drug Kinetics;Fc domain;FDA approved;first-in-human;Funding;Future;Half-Life;Human;humanized mouse;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunoglobulin Fragments;Immunosuppressive Agents;Immunotherapeutic agent;Immunotherapy;In Vitro;in vitro activity;in vivo;Intravenous infusion procedures;Invaded;Investigational Therapies;Lectin;Malignant Neoplasms;manufacture;Metastatic/Recurrent;Motility;mouse model;National Cancer Institute;National Cancer Program;neonatal Fc receptor;neonatal human;Neoplasm Metastasis;new technology;Normal Cell;Normal tissue morphology;novel;novel therapeutics;overexpression;palliative;Patients;Phase;Phase I Clinical Trials;phase I trial;Phosphatidylinositols;Phosphotransferases;Polysaccharides;pre-clinical;preclinical development;prevent;Prognosis;programmed cell death protein 1;programs;Proteins;Receptor Protein-Tyrosine Kinases;Refractory;Regulatory T-Lymphocyte;Relapse;Safety;safety assessment;Sequential Treatment;Serum;Signal Pathway;Signal Transduction;Solid;Solid Neoplasm;Specificity;stable cell line;sugar;Surface;Surface Antigens;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Toxic effect;Transgenic Mice;Tumor Antigens;tumor growth;Work

PROJECT_TITLE: Extended half-life GlyTR1 combined with checkpoint blockade for Cancer Immunotherapy


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Liver cancer, also known as hepatocellular carcinoma (HCC), is the fastest growing cause of cancer-related deaths among Americans with liver disease. Fatty liver disease related to metabolic dysfunction (e.g., diabetes, obesity), also called MAFLD, has become the most common liver disease in the world. Our research is significant because it investigates several risk factors and novel biomarkers that can be reliably used to identify subgroups of MAFLD patients with an increased HCC risk, so they can be targeted for prevention and early detection.

PI_NAMEs: EL-SERAG, HASHEM B (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;adipokines;Age;Alcohol abuse;American;Anti-Inflammatory Agents;Biological Assay;biomarker discovery;biomarker selection;blood-based biomarker;Body fat;Body mass index;Calibration;Cancer Etiology;candidate identification;candidate marker;capsule;Cessation of life;Characteristics;Chemoprevention;Chronic;Chronic viral hepatitis;Cirrhosis;Cities;clinical practice;cohort;Collection;comparative cost effectiveness;cost effectiveness;CSPG3 gene;cytokine;Data;Diabetes Mellitus;Diastolic blood pressure;Discrimination;disease phenotype;Early Diagnosis;ethnic minority;Ethnic Origin;Etiology;Event;Fatty acid glycerol esters;fatty liver disease;follow-up;Functional disorder;General Population;Genetic;Genetic Markers;genetic risk factor;Glycosylated hemoglobin A;Goals;Growth;Hepatitis B;Hepatitis C;Heterogeneity;High Density Lipoprotein Cholesterol;High Prevalence;high risk;Hispanic Populations;Image;imaging biomarker;improved;indexing;Individual;Infrastructure;Insulin;Insulin Resistance;Lesion;Life Style;lipidomics;Lipids;Liver;Liver diseases;liver imaging;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;metabolic-associated fatty liver disease;metabolomics;Methods;Modeling;molecular marker;Nature;Nested Case-Control Study;novel;novel marker;Obesity;Pathway interactions;Patients;Performance;Persons;Physical activity;polygenic risk score;practice setting;Predictive Value;Prevention;Primary carcinoma of the liver cells;programs;progression risk;prospective;Prospective cohort;Prospective, cohort study;quantitative imaging;Race;racial minority;radiomics;recruit;Research;Risk;Risk Factors;risk prediction;risk stratification;Sampling;Serum;sex;Site;Skin;Smoking;Specificity;Subgroup;Survival Rate;synergism;Texas;tool;Triglycerides;Ultrasonography;ultrasound;Validation;Variant;Waist-Hip Ratio

PROJECT_TITLE: HCC Risk Stratification in MAFLD Cirrhosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Lung;Lung Cancer;Nanotechnology;Precision Medicine;Radiation Oncology

ORG_CITY: Portland

ORG_NAME: PDX PHARMACEUTICALS, INC.

ORG_STATE: OR

PHR: Narrative Lung cancer is the leading cause of cancer deaths, accounting for 25% of all cancer mortalities - more than colon, breast, and prostate cancer combined. We propose to develop a nanotherapeutic named PETTRA that simultaneously targets PLK1 and EGFR in approximately 50% of all lung cancer patients regardless of mutational status. PETTRA will be a first-in-class molecularly-targeted therapy that is also a radiation sensitizer for lung cancer, which will benefit about 60% of patients undergoing radiation therapy.

PI_NAMEs: NGAMCHERDTRAKUL, WORAPOL  (contact);YANTASEE, WASSANA

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: A549;Abscopal effect;Accounting;Antibodies;Apoptotic;Benchmarking;Bilateral;Biodistribution;Biological Availability;Biological Markers;Biomedical Engineering;Blood;Blood Chemical Analysis;Blood Circulation;Body Weight;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Cycle Arrest;Cell Death;Cell division;cell killing;Cell Line;Cell Survival;Cells;Cessation of life;Cetuximab;chemotherapy;Circulation;Cisplatin;Clinic;Clinical Trials;clinically relevant;Collaborations;Colon Carcinoma;cost;Data;DNA Repair;Dose;Drug Kinetics;Epidermal Growth Factor Receptor;Exhibits;FDA approved;G2/M Arrest;Genes;Half-Life;Health;Hematology;Histology;Home;Homing;humanized mouse;Immune;Immunohistochemistry;In Vitro;in vivo;inhibitor;Investigational New Drug Application;knock-down;Laboratories;Lead;lead candidate;Lipids;Liver;liver function;Luciferases;Lung;lung cancer cell;Lung Neoplasms;M cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Methods;Mitosis;Modeling;Molecular Target;molecular targeted therapies;Monitor;Monkeys;mortality;mouse model;Mus;mutational status;Names;nano;nanoparticle;nanoparticle delivery;nanotherapeutic;new therapeutic target;Non-Small-Cell Lung Carcinoma;nonhuman primate;Normal Cell;novel;novel therapeutics;Organ;Outcome;overexpression;panitumumab;particle;Particle Size;patient derived xenograft model;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacologic Substance;Phase;PLK1 gene;Positioning Attribute;precision medicine;prototype;Radiation;Radiation induced damage;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Renal function;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Role;Safety;Saline;siRNA delivery;Small Business Innovation Research Grant;Small Interfering RNA;small molecule inhibitor;Solid Neoplasm;Specificity;success;Surface;synergism;targeted agent;targeted delivery;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Index;therapy outcome;Toxic effect;Toxicology;tumor;Tumor Burden;tumor growth;uptake

PROJECT_TITLE: PLK1 and EGFR targeted nanoconstruct as a monotherapy and a radiation sensitizer for lung cancer


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Genetic testing for characterizing and identifying hereditary risk related to carrier screening, newborn screening, and cancer predisposition testing has transformed prevention and care efforts for many, yet underserved groups like Latinx groups are benefiting at the same rate as white populations. A critical understudied area of genetic testing utilization for Latinx groups is perceived facilitators and barriers, and without a robust understanding of these factors, strategic communication campaigns likely will not have desired effects of improved genetic testing utilization. Thus, the current study will characterize attitudes, facilitators, and barriers of Latinx individuals' experiences with genetic testing using semistructured elicitation interviews, then testing associations between these factors with a designed survey from interviews administered with a Qualtrics Panel of 500 Latinx individuals to identify the best factors for intervention using culturally appropriate translational strategic communication research efforts.

PI_NAMEs: CHAVEZ-YENTER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Achievement;Address;Area;Attitude;barrier to testing;Behavioral;Behavioral Model;Benefits and Risks;Black Populations;cancer genetics;cancer predisposition;Caring;carrier testing;Chemoprevention;Cohort Studies;Communication;Communication Research;community based research;community organizations;design;Diffusion;Equation;ethnic minority;Ethnic Population;experience;Gender;Genetic;Genetic Research;genetic testing;Genomic medicine;Genomics;Germ Lines;Goals;Grant;Health;health equity;health inequalities;hereditary risk;Human Genome Project;implementation intervention;improved;Influentials;innovation;Intention;Interdisciplinary Study;interest;Intervention;Intervention Studies;Interview;Knowledge;Latino;Latinx;Latinx population;Malignant Neoplasms;Medical;Mentors;Methods;Modeling;National Human Genome Research Institute;Neonatal Screening;novel;Outcome;Participant;Perception;Phase;Population;Positioning Attribute;Postdoctoral Fellow;Predictive Factor;Prevention;Privacy;programs;Provider;Public Health;racial minority;racial minority population;racial population;Recommendation;Research;Research Personnel;Research Training;Resources;Sampling;Scholarship;screening guidelines;Site;social health determinants;Strategic Planning;Structure;Surveys;Technology;Testing;Training;Translating;translational approach;Translational Research;Underrepresented Populations;underserved community;Underserved Population;Work

PROJECT_TITLE: Investigating Latinx populations’ attitudes, perceptions, and use of genomic testing

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed studies of the visual experience of infants are relevant to public health because impaired vision and visual learning have long term consequences across many domains of a healthy and successful life. Disrupted visual experience in infancy is evident in the continued risk in perceptual, cognitive and school achievements and is implicated in the nexus of disrupted visual learning and motor development of children with more general developmental disorders. Determining the expected and normative early visual input in infancy and its links to infant eye- movements and behaviors is expected to give rise to new diagnostics and behavioral interventions for at-risk infants.

PI_NAMEs: SMITH, LINDA B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Achievement;Age;Age Months;Anisometropia;Behavior;behavior change;behavior influence;Behavior Therapy;Birth;Cataract;Characteristics;Child Development;Cognition;Cognitive;Color;Development;developmental disease;early experience;Educational Curriculum;Esthesia;experience;Eye;Eye Movements;Face;falls;Frequencies;gaze;Goals;Hand;Hand functions;Head;Head Movements;Health;Home;Hour;Human;Image;infancy;Infant;Infant Behavior;interest;Laboratories;Laboratory Study;large datasets;Life;Link;Literature;Measures;Motion;motion sensor;Motor;Movement;novel;novel diagnostics;Outcome;Pattern;Persons;Play;Positioning Attribute;postnatal;Posture;preference;Property;Ptosis;Public Health;Refractive Errors;Research;Retina;Risk;Role;Sampling;Schools;Semantics;Series;statistics;Strabismus;Structure;Testing;Vision;vision development;Visual;Visual Cortex;Visual impairment;visual information;visual learning;visual motor;Visual System;visual tracking;Work

PROJECT_TITLE: The Statistics of Infant First-Person Visual Experience

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: APPLICATION NARRATIVE Optic neuropathy is a class of devastating vision threatening diseases that affect the optic nerve, and there are no methods to selectively deliver therapeutics to the optic nerve head. A delivery technique to the optic nerve head will be developed, and the safety, distribution, and efficacy will be compared against intravitreal and intraorbital optic nerve injections. Delivery techniques to the optic nerve head could improve treatment options for optic neuropathies, and facilitate further studies on disease pathogenesis and treatment options for millions of patients with optic neuropathies.

PI_NAMEs: CHIANG, BRYCE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;American;Animal Model;Animals;Attention;Autopsy;Award;Axon;axon injury;axon regeneration;Biology;Caliber;Catheters;Cells;central retinal vein occlusion;Ciliary Neurotrophic Factor;Clinical;Cues;Data;Dependovirus;design;Disease;disease model;Doctor of Philosophy;Dose;Drug Delivery Systems;Edema;Electroretinography;Eye;FDA approved;Fellowship;Formulation;Functional disorder;Fundus photography;Glaucoma;Growth Cones;Growth Factor;Health;Histology;Human;improved;improved outcome;in vivo;Infusion procedures;Injections;injured;Ischemia;K-Series Research Career Programs;Label;Length;macromolecule;macula;Measures;Mentors;Mentorship;Metabolic;Methods;nano;Natural regeneration;Needles;Nerve Regeneration;Neuroglia;neuronal cell body;neuroprotection;neurotransmission;non-invasive imaging;novel;Operative Surgical Procedures;Ophthalmology;Optic Disk;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Optical Coherence Tomography;optical imaging;Optics;Oryctolagus cuniculus;Papillary;particle;Pathogenesis;Pathologist;Pathway interactions;Patients;Pattern;Physiological;Polymers;preclinical study;Prevention;professor;Proteins;Radial;Reporter;Research;Research Personnel;Residencies;Retinal Detachment;retinal ganglion cell regeneration;Retinal Ganglion Cells;retinal nerve fiber layer;Retinal Perforations;retinal toxicity;Route;Safety;Scientist;side effect;skills;small molecule;spatiotemporal;Surgeon;targeted delivery;Techniques;Technology;Therapeutic;therapeutic candidate;Time;timeline;Tissues;tonometry;tool;Tracer;Training;translational therapeutics;Viscosity;Vision;Work

PROJECT_TITLE: Localization, safety, and efficacy of optic nerve injections


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: COX, NANCY J;MILLER-HUGHES, STEPHANIA T.;WEISS, ROY E;WILKINS, CONSUELO HOPKINS (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Southeast Collaborative for Innovative and Equitable Solutions to Chronic Disease Disparities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a leading cause of death and disease among Black American women and is associated with pregnancy complications and experiences of early and chronic stress. We will measure health and behavioral indicators of CVD risk in a sample of Black women who have participated in a 20-year longitudinal study to examine the effects of lifetime stress exposure and stress reactivity on profiles of CVD risk across the first two years postpartum. New data from this study will improve understanding of CVD risk specific to Black women, and will inform the targets and timing of interventions to reduce persistent racial disparities in maternal health.

PI_NAMEs: HIPWELL, ALISON E (contact);LEVINE, MICHELE D

PROGRAM_OFFICER_NAME: PLEVOCK HAASE, KAREN MARIE

PROJECT_TERMS: Acute;acute stress;Address;Adult;adverse birth outcomes;Affect;Age Years;behavior change;Behavioral;biobehavior;Biological;biopsychosocial;Birth;Black American;Black race;black women;Blood;Blood Glucose;Blood Pressure;Buffers;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;causal model;Cause of Death;Childhood;Chronic stress;Conceptions;Data;Development;Diet;dietary;Discipline of obstetrics;Discrimination;Disease;early experience;Early identification;Exposure to;Fetal Development;Future;girls;Health;Health Personnel;Healthcare;heart rate variability;Heterogeneity;Hydrocortisone;improved;Individual Differences;inflammatory marker;innovation;Intervention;Knowledge;Laboratories;life span;Life Stress;Link;Lipids;Longitudinal Studies;Low income;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;minority stress;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Obesity;Outcome;Pathway interactions;Perinatal;Persons;Phenotype;Physiological;Polyunsaturated Fatty Acids;post pregnancy;postpartum health;Postpartum Period;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnancy Trimesters;Pregnant Women;prenatal;Prenatal care;prenatal stress;Prevention;Prevention Guidelines;preventive intervention;Primary Prevention;Prospective Studies;protective effect;Race;racial disparity;racial health disparity;racism;recruit;Regulation;Reproductive Health;Research;response;Risk;Risk Assessment;Role;Salivary;Sampling;Second Pregnancy Trimester;Smoking;Stress;stress reactivity;stress reduction;Stress Tests;stressor;System;Testing;theories;Third Pregnancy Trimester;Time;Violence;White Women;Woman;Women's Health;women's morbidity;Women's mortality;Work

PROJECT_TITLE: Preconception and prenatal stress effects on cardiovascular disease risk in black women


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cachexia;Cancer;Clinical Research;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Pancreatic Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: The overarching goal of this proposal is to develop and validate privacy-preserving multimodal machine/deep learning (ML/DL) models for the early detection of cachexia across multiple cancer types and risk stratification of PDAC from IPMNs using clinical, imaging, genetic mutational, and social determinants of health (SDOH) data. To access large-scale representative data while respecting the privacy and the security of sensitive patient data, this proposal leverages Federated Learning (FL). Moffitt Cancer Center will act as a server and as a site for other projects.

PI_NAMEs: CLEVELAND, JOHN L. (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: abdominal CT;Artificial Intelligence;artificial intelligence model;Attention;Benchmarking;Blood Chemical Analysis;Body mass index;Body Weight decreased;CA-19-9 Antigen;Cachexia;Cancer Cachexia;Cancer Center;Cancer Detection;Cancer Patient;cancer risk;cancer type;Client;Clinical;Clinical Data;Colorectal Cancer;Data;data modalities;Data Set;Data Sources;deep learning;deep learning model;demographics;Development;diverse data;DNA Sequence Alteration;Early Diagnosis;Early Intervention;Electronic Health Record;Employment Status;Ensure;Environment;Family;federated learning;fitness;food insecurity;Genes;Goals;gradient boosting;graph neural network;health care availability;health data;Health Insurance Portability and Accountability Act;Hematoxylin and Eosin Staining Method;Histopathology;Housing;Image;imaging biomarker;improved;indexing;Institution;Intervention;KRAS2 gene;Lead;Lymphocyte Count;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Micro Array Data;model development;model generalizability;Modeling;Mucinous Neoplasm;multimodality;Muscular Atrophy;neutrophil;Obesity;Oncology;Pancreatic Cyst;Pancreatic Ductal Adenocarcinoma;Papillary;patient privacy;Patient-Focused Outcomes;Patients;Performance;Population;predictive modeling;Privacy;privacy preservation;Publications;Quality of life;radiomics;Recording of previous events;Regulation;Risk Factors;risk prediction model;risk stratification;Scanning;Security;Semantics;Serum Albumin;Site;Skeletal Muscle;Smoking;social health determinants;Socioeconomic Status;Structure;Survival Rate;Syndrome;Tissue Stains;TP53 gene;Training;Update;Visit;webinar;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Multimodal Federated Learning for Pan-Cancer Detection of Cachexia and Early Detection of Pancreatic Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Violence Research

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Elder neglect by a caregiver can have serious health consequences for older adults with Alzheimer’s Disease and related dementias but it is seldom identified and addressed. We propose to develop a screening tool for primary care providers to improve identification of elder neglect and a point-of-care intervention to support caregivers who may be neglecting an older adult. Findings from this research will improve the ability of health care providers to identify, intervene, and prevent neglect and improve the health of this vulnerable population.

PI_NAMEs: LACHS, MARK STEVEN;ROSEN, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Address;Alzheimer's disease patient;Alzheimer's disease related dementia;arm;brief screening;Caregiver Burden;caregiver interventions;Caregiver support;Caregivers;caregiving;Cellular Phone;Characteristics;Clinical;Cognitive;comparison intervention;Consumption;data registry;Dementia;design;Disadvantaged;Education;Elder Abuse;elder neglect;Equilibrium;evidence base;Exposure to;Focus Groups;Goals;handheld mobile device;Health;Health Personnel;ideation;implementation tool;improved;innovation;Intervention;Interview;Knowledge;maltreatment;Measures;Modeling;Morbidity - disease rate;mortality;neglect;novel;older adult;Outcome;Patients;Phase;pilot test;point of care;Point of Care Technology;Population;prevent;Primary Care;primary care provider;Process;protocol development;Provider;randomized, clinical trials;Randomized, Controlled Trials;Research;Resources;Risk;screening;screening guidelines;Screening procedure;Sensitivity and Specificity;Severities;skills;standard measure;Tablets;Technology;technology intervention;Testing;tool;Training;treatment as usual;tv watching;United States National Institutes of Health;United States Preventative Services Task Force;usability;Vulnerable Populations

PROJECT_TITLE: Primary Care Screening and Intervention for Elder Neglect in Patients with Dementia: An Evidence-Based Approach


NIH_SPENDING_CATS: Clinical Research;Lung;Precision Medicine;Pulmonary Hypertension

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The field of Redox Biology is rapidly advancing with the introduction of improved tools and insight to understand how disrupted redox-regulated signaling pathways contribute to pathogenesis of pulmonary vascular diseases. This project will establish how the content or distribution of a critical vascular antioxidant enzyme, extracellular superoxide dismutase, contributes to pathologic redox regulated signaling in pulmonary hypertension and provide the foundation for novel targeted therapeutic approaches.

PI_NAMEs: NOZIK, EVA S. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Age;Animal Model;antioxidant enzyme;Award;Binding;Biology;Blood Vessels;CD44 gene;Cell Communication;Cells;design;Development;Disease;Electron Spin Resonance Spectroscopy;enzyme activity;epigenetic regulation;experimental study;extracellular;Extracellular Matrix;Fibroblasts;Fibrosis;Foundations;Funding;Future;Gene Expression;Genetic Polymorphism;Growth;Half-Life;Homeostasis;Human;Hyaluronan;improved;In Vitro;in vivo;Individual;individual variation;Inflammasome;Inflammation;insight;Knock-in;Knowledge;Location;Lung;Macrophage;Metabolism;Mission;mitochondrial dysfunction;Modification;Mouse Strains;Mus;Natural Immunity;new therapeutic target;novel therapeutic intervention;Oxidation-Reduction;Pathogenesis;Pathologic;Precision Medicine Initiative;Predisposition;programs;Property;Pulmonary Circulation;Pulmonary Hypertension;pulmonary vascular disorder;receptor;Regulation;Research;Research Infrastructure;Research Project Grants;Resource Sharing;response;Series;Severities;Signal Pathway;Signal Transduction;Superoxide Dismutase;Testing;tool;Transforming Growth Factor beta;Translating;Translations;Vascular remodeling;Work

PROJECT_TITLE: SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging;Palliative Care

PHR: Project Narrative Despite advances in clinical care and education, gaps remain in the evidence base to inform clinical palliative care, especially for older adults. One of the most important ways to advance care for older adults with advanced illness is through the development of junior investigators who will contribute to generation of evidence and build the academic critical mass necessary for the future of the field. Although clinical fellowship programs in palliative care have been growing in number and quality, there remains a paucity of research training opportunities in palliative care. The goal of this T32 is to prepare postdoctoral physician and PhD scientists for careers as aging-related palliative care researchers.

PI_NAMEs: FISCHER, STACY M;KUTNER, JEAN S (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Interdisciplinary Study;Palliative Care;Research Training

PROJECT_TITLE: Multidisciplinary Research Training in Palliative Care


NIH_SPENDING_CATS: Cancer;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: FOGELGREN, BENJAMIN C. (contact)

PROGRAM_OFFICER_NAME: WONNUM, SUNDANIA J W

PROJECT_TERMS: Address;Affect;base;Behavioral Research;Biomedical Research;Biometry;Businesses;career development;Clinical Research;Collaborations;Communication;Communities;community collaboration;community engagement;Consultations;Core Facility;Data Science;design;Development;Diagnosis;Direct Costs;Discipline;disorder prevention;Effectiveness;effectiveness evaluation;effectiveness research;ethnic minority population;Evaluation Research;experience;Extramural Activities;Faculty;Funding;Grant;Hawaii;Health Disparities Research;health disparity;Histopathology;HPV vaccine acceptance;innovation;Institution;Leadership;Link;Marketing;Mentors;minority health;minority health disparity;Modernization;Needs Assessment;outreach;Pilot Projects;Policies;Procedures;Productivity;programs;Publications;Reduce health disparities;Regulation;Research;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;satisfaction;Science;Scientist;Services;Stream;Structure;success;Technical Expertise;tool;Training;Training and Education;Training Programs;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Research Capacity Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  The Collaborative Pediatric Critical Care Research Network (CPCCRN) includes 24 pediatric intensive care units and an established Data Coordinating Center with independent medical and biostatistical expertise. Build- ing on its strong track record of successful clinical trials and innovative work in immune phenotyping in pediatric sepsis, the CPCCRN will carry out a large-scale multicenter randomized controlled trial using personalized test- ing and targeted management of immune function in infants and children with sepsis-induced multiple organ dysfunction syndrome (MODS), one of the most frequent causes of mortality and morbidity in critical care.

PI_NAMEs: DEAN, JONATHAN MICHAEL;WATT, KEVIN M (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;Adult;adverse outcome;anakinra;Biometry;C-reactive protein;Child;Childhood;Clinical;clinical research site;Clinical Trials;Collaborations;Communication;Community Healthcare;Critical Care;Critically ill children;Data Coordinating Center;Development;Drug usage;Ethnic Origin;Evidence based treatment;expectation;Family;Ferritin;Frequencies;Functional disorder;Funding;Geography;Granulocyte-Macrophage Colony-Stimulating Factor;health assessment;health related quality of life;Immune;immune function;Immune response;Immune Targeting;Immunologic Adjuvants;Immunologic Monitoring;Immunophenotyping;immunoregulation;Immunosuppression;improved;improved outcome;Infant;Inflammation;innovation;Institution;Intervention Studies;Laboratories;Measures;Medical;meetings;Morbidity - disease rate;mortality;Multicenter Studies;Multiple Organ Failure;National Institute of Child Health and Human Development;Observational Study;Organ;pathogen;Patients;Pediatric Intensive Care Units;pediatric sepsis;Performance;Pharmaceutical Preparations;Phenotype;Placebo Control;Positioning Attribute;primary outcome;Procedures;Protocols documentation;Race;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk Factors;Science;Scientist;secondary outcome;Sepsis;septic;Severities;Site;socioeconomic diversity;Structure;Supportive care;targeted treatment;Testing;Time;timeline;tocilizumab;Treatment Protocols;Universities;Utah;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Mental Health;Prevention;Primary Health Care;Sleep Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: 8. PROJECT NARRATIVE Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future. This mechanistic study will determine if our updated insomnia treatment called SHADES improves biological factors thought to explain how insomnia promotes CVD and if these improvements are due to positive changes in sleep factors. This study could generate the critical evidence needed to justify a large clinical trial to determine if SHADES can help prevent CVD events, such as heart attacks and strokes.

PI_NAMEs: STEWART, JESSE C (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: active control;Address;Adult;Affect;Aftercare;Age;aged;Attention;Autonomic Dysfunction;Behavior Therapy;Biological;Biological Factors;Biological Markers;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Caring;Clinical;Clinical Trials;cognitive testing;Cognitive Therapy;cohort;collaborative care;Conditioned Insomnia;cost;Data;design;Development;Disparity population;Education;effective intervention;Effectiveness;Enrollment;Ethnic Population;Event;Exhibits;Federally Qualified Health Center;follow-up;Frequencies;Functional disorder;Future;Gene Expression;Gene Expression Profiling;genome-wide;Glycosylated hemoglobin A;Goals;Health;Healthcare Systems;Heart;heart rate variability;high risk;Homeostasis;Hygiene;improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;Interleukin-6;Internet;Intervention;intervention effect;intervention refinement;Mediating;Mediator;men;Metabolic;Minority;Modeling;Modernization;modifiable risk;Monitor;Morbidity - disease rate;Myocardial Infarction;National Heart, Lung, and Blood Institute;next generation;Outcome;Participant;Pathway interactions;patient population;Patients;Peripheral Blood Mononuclear Cell;Persons;Phase;phase III trial;prevent;Prevention strategy;Primary Care;primary care patient;primary outcome;programs;psychologic;public health relevance;racial population;Randomized;Research;Risk;Risk Factors;RNA;safety net;Science;screening;secondary outcome;sex;Site;Sleep;Sleep disturbances;sleep onset;Sleeplessness;Source;statistics;Stroke;Symptoms;systemic inflammatory response;Telephone;Testing;Update;Woman

PROJECT_TITLE: Strengthening Hearts by Addressing DisruptEd Sleep (SHADES) Mechanistic Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Gain of function mutations in motor protein KIF5A are an emerging cause of pathogenesis in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). This proposal investigates how ALS/FTD causative mutations in KIF5A affect its function in axonal transport and cytoskeletal regulation. Our findings will provide insights into the critical roles KIF5A in neuronal health and lay the foundation for rational design of therapeutics to treat KIF5A ALS/FTD.

PI_NAMEs: BRENT, JONATHAN ROBERT (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Age;age related;aged;ALS patients;Amyotrophic Lateral Sclerosis;Applications Grants;Axon;Axonal Transport;Behavior;Behavioral;Binding;Biochemical;Biology;Brain;C-terminal;career development;causal variant;Cells;Cessation of life;cognitive function;cohort;Complex;confocal imaging;CRISPR/Cas technology;Cytoplasmic Granules;Cytoskeleton;Data;Defect;Development;Development Plans;Disease;Distal;Doctor of Medicine;Doctor of Philosophy;Exclusion;Exons;Fluorescence Microscopy;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Future;gain of function;gain of function mutation;Genetic;Genetic Engineering;genetic regulatory protein;Genetically Engineered Mouse;Gliosis;Goals;Health;Homeostasis;human disease;human induced pluripotent stem cells;Hyperactivity;Image;Imaging Techniques;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Kinesin;Knowledge;Label;Language;live cell imaging;Longevity;Lysosomes;Maintenance;Manuscripts;Mentors;Mentorship;Microtubules;Mitochondria;Morphology;Motility;Motor;Motor Neuron Disease;Motor Neurons;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurites;Neurodegenerative Disorders;neurofilament;Neuromuscular Junction;neuron loss;Neurons;novel;Organelles;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Physicians;Post-Translational Protein Processing;Preparation;Production;programs;protein aggregation;protein TDP-43;Proteins;Proteomics;Publications;rational design;Records;Regulation;Research;Resources;RNA;RNA Interference;RNA Splicing;Role;Scientist;Site;skills;Slide;small molecule;Solid;Spinal Cord;Splice-Site Mutation;Structure;Synapses;Techniques;Testing;Therapeutic;Time;Tissues;tool;trafficking;Training;Transmission Electron Microscopy;ultra high resolution;Universities;Western Blotting;Work

PROJECT_TITLE: Mechanisms of Neurodegeneration in KIF5A ALS/FTD

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PI_NAMEs: NAGHIZADEH SAFA, BABAK  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acute;Address;Adrenergic Agents;Affect;Age;Anatomy;Animal Model;Animals;Anterior;anterior chamber;Anti-Cholinergics;Aqueous Humor;Basic Science;biomechanical test;Biomechanics;Blindness;Cadaver;career;Cholinergic Agents;Clinical;Clinical Research;clinical risk;Clinical Trials;comparison control;Computer Models;constriction;Data;Development;Dilator;Disparity;Elements;Engineering;Evaluation;Eye;Female;Functional disorder;Future;Glaucoma;high risk;Histology;Human;human subject;Hybrids;Image;improved;in vivo;in vivo evaluation;Individual;Iris;Learning;lens induction;Light;Link;male;Measures;Mechanics;medically necessary care;Mentors;Modeling;Morbidity - disease rate;Muscle;Muscle Contraction;Mydriasis;Oryctolagus cuniculus;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Physiologic Intraocular Pressure;Physiological;Play;pressure;Prevalence;prevent;Primary Angle Closure Glaucoma;Property;Protocols documentation;Public Health;Pupil light reflex;Race;Recording of previous events;Relaxation;Research Personnel;Risk;Risk Factors;risk stratification;Role;sex;Sex Differences;skills;Sphincter;Study Subject;Techniques;Testing;therapeutic target;Tissues;Traction;Training;Validation;Woman;Women's prevalence

PROJECT_TITLE: The role of iris biomechanics and sex differences in primary angle-closure glaucoma

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE In this multi-site study, we will link geospatial environmental measures with electronic health records from health systems across the United States to elucidate the scope and magnitude of pediatric health risks resulting from extreme weather events, such as heatwaves and intense rainstorms. Results will provide evidence of acute health impacts from recent weather extremes, as well as novel data on chronic health outcomes associated with exposure to multiple extreme weather events over time. Quantification of disproportionate impacts borne by marginalized community-member children will provide information that is critically needed to support policies intended to prevent further harm from climate extremes and to promote health equity.

PI_NAMEs: DE ROOS, ANNECLAIRE J (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;acute care;Adverse effects;Age;Air Conditioning;Allergic rhinitis;Area;Asthma;asthma exacerbation;Birth;built environment;Caregivers;Censuses;Characteristics;Child;Child Health;Childhood;Childhood Asthma;Chronic;Chronic Gastritis;Climate;climate change;climate zone;cohort;County;Data;data infrastructure;Databases;Dehydration;Dependence;Development;Diagnosis;Disasters;Disparity;Electronic Health Record;Emergency department visit;Environment;Equity;Ethnic Origin;Etiology;Evaluation;Event;Exposure to;extreme heat;extreme weather;Floods;follow-up;Funding;Gastroenteritis;Geography;hazard;Health;health equity promotion;health inequalities;Health system;Heat Waves;Hour;Housing;Individual;Inequity;infancy;Infrastructure;Injury;Insurance;Investigation;Knowledge;land cover;large scale data;Link;Literature;marginalized community;Measures;member;Mental disorders;Meteorology;Modeling;Morbidity - disease rate;Neighborhoods;novel;Obesity;Outcome;Overweight;patient population;Patients;pediatric health outcomes;Philadelphia;Policies;Positioning Attribute;prevent;Public Health;Race;Rain;regional difference;Reporting;Research;Resolution;Respiratory Tract Infections;response;Risk;Scientific Advances and Accomplishments;Shapes;Site;social;Social Environment;spatiotemporal;Specific qualifier value;systematic review;Temperature;Testing;Time;Trees;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Extreme Weather Impacts on Children's Acute and Chronic Health Outcomes: A Multi-Site Study with Evaluation of Vulnerabilities

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Because Latino children are disproportionately affected by short sleep duration, poorly timed sleep, and obesity by the age of 3 years, it is critical to understand factors that may contribute to both sleep and obesity in this population. This study will advance our understanding of how environmental (e.g., household, neighborhood, societal), sociocultural (e.g., acculturation, beliefs), and parental (e.g., sleep-related parenting practices) factors contribute to toddler sleep and toddler weight status over a 2-year period in Mexican American families, one of the largest growing ethnic minority populations in the U.S. By identifying contextual factors and modifiable behaviors that must be considered for intervention design, this study will contribute to the development of family-focused, culturally-tailored, and contextually-informed early prevention programs focused on sleep and weight status in this underserved population.

PI_NAMEs: MELTZER, LISA J;THOMPSON, DARCY ANN (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 3 year old;Acculturation;actigraphy;Adolescent;Affect;Area;Belief;Child;Child Rearing;Childhood;contextual factors;critical developmental period;Data;design;Development;Devices;Diet;Disparate;Disparity;early childhood;early-onset obesity;Ecology;Enrollment;Ensure;Environmental Risk Factor;ethnic minority population;Evaluation;Family;Fathers;Focus Groups;Future;Growth;Health;Health behavior;high risk;Home;Household;Household and Family;Hypertension;improved;innovation;Intervention;Knowledge;Latino;Life;Long-Term Effects;Longitudinal Studies;Low income;Measurement;Measures;Mediator;metropolitan;Mexican Americans;Modeling;modifiable behavior;Mothers;multidisciplinary;Napping;neighborhood disadvantage;Neighborhoods;Noise;Nursery Schools;Obesity;obesity in children;obesity prevention;Outcome;Parents;Physical activity;Population;Prevalence;Prevention program;primary caregiver;Qualitative Methods;Questionnaires;Reduce health disparities;Reporting;Research;resilience;response;Schedule;Sleep;sleep behavior;Sleep Deprivation;social culture;sociocultural determinant;System;Systems Theory;Target Populations;therapy design;Time;Toddler;Underserved Population;Weight;Work

PROJECT_TITLE: Sleep and Obesity in Toddlers from Mexican American Families


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Contact PD/PI: Robinson, James E Project Narrative SARS-CoV-2, the virus which causes COVID-19, is one of the most devastating human pathogens of our time. The Tulane University COVID Antibody and Immunity Network (TUCAIN) will mechanistically define the immune response to this virus to determine how it protects individuals from infection and how long that protection lasts. By creating large integrated data sets of immunological and clinical data as well as characterized blood samples, we will be able to construct sophisticated methods to diagnose, and improve treatment of infected individuals. Project Narrative Page 124

PI_NAMEs: ROBINSON, JAMES E (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Administrative Supplement;Adult;Algorithms;Antibodies;B-Lymphocytes;Big Data;Blood;Blood specimen;booster vaccine;breakthrough infection;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cellular Immunity;Clinical Data;cohort;Collection;comparative efficacy;Control Groups;convalescent plasma;COVID-19;COVID-19 pandemic;COVID-19 survivors;COVID-19 treatment;CRISPR/Cas technology;data integration;Data Set;Death Rate;Defect;Development;Diagnosis;Disease;Enrollment;Evolution;Frequencies;Funding;General Population;Generations;Goals;Hematologic Neoplasms;HIV;HIV Infections;human pathogen;Humoral Immunities;Immune;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunologic Memory;Immunologics;improved;Individual;Infection;insight;Kinetics;Knowledge;Link;Louisiana;Malignant Neoplasms;Measures;Mediating;Medicine;Memory B-Lymphocyte;Methods;Mission;Multiple Myeloma;neutralizing antibody;novel;parent grant;Pathogenesis;Pathogenicity;patient population;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Plasma;Plasma Cells;Population;Predisposition;prevent;Recurrence;Reporting;Research;response;Risk;RNA vaccination;RNA vaccine;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 immunity;SARS-CoV-2 infection;Secondary Immunization;Series;Serology;Serology test;Serum;Solid Neoplasm;Systems Biology;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;Time;treatment strategy;Universities;Vaccination;vaccine efficacy;Vaccines;Variant;variants of concern;Viral;Viral Load result;Virus;virus testing;Visit;Vulnerable Populations

PROJECT_TITLE: Tulane University COVID Antibody and Immunity Network (TUCAIN) Supplement


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Rare Diseases;Wound Healing and Care

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project narrative: Current therapies for autoimmune disease chronically suppress the immune system, which risks severe infection. DSG3-CAART is the first precision T cell immunotherapy for autoimmune disease to enter clinical trials, which presents a unique opportunity to investigate the immunomodulatory effects of this novel targeted therapeutic approach in humans. The proposed studies will elucidate the cellular and molecular determinants of DSG3-CAART activity and host immune response, using clinical samples collected from subjects enrolled in the DSG3-CAART phase 1 study.

PI_NAMEs: PAYNE, AIMEE S (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adhesions;Adoptive Transfer;Antibody titer measurement;Antigen Targeting;Area;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune Diseases;Autoimmunity;Automobile Driving;B lymphoid malignancy;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;biomarker identification;Blood Component Removal;Bulla;cancer cell;cancer therapy;CD19 gene;Cell Compartmentation;cell killing;Cell surface;Cell Therapy;Cells;Cellular immunotherapy;cellular targeting;chimeric antigen receptor;chimeric antigen receptor T cells;chronic autoimmune disease;Clinical;Clinical Trials;cohort;Collecting Cell;cytokine;Cytoplasm;Cytotoxic Chemotherapy;cytotoxicity;Data;design;desmoglein III;Disease;Disease remission;Dose;Engineering;Enrollment;Enzyme-Linked Immunosorbent Assay;Epithelium;Evaluation;exhaustion;Experimental Models;experimental study;Extracellular Domain;first-in-human;Flow Cytometry;Gene Expression Profiling;Genetic Engineering;Human;human model;Immune response;Immune system;Immune Tolerance;Immunize;Immunological Models;immunoregulation;Immunotherapy;In Vitro;in vitro Model;in vivo;indexing;Infection;Infusion procedures;Investigational New Drug Application;Link;manufacture;Memory;Memory B-Lymphocyte;Molecular;molecular marker;Molecular Profiling;Mucous Membrane;Mus;new therapeutic target;novel therapeutic intervention;open label;Pathologic;Pathway interactions;Patients;Pemphigus;Pemphigus Vulgaris;peripheral blood;phase 1 study;phase I trial;Phenotype;Plasmablast;Pre-Clinical Model;Proteins;Proteome;Proteomics;receptor;Refractory;response;Risk;Safety;Sampling;Serious Adverse Event;Serology;Serum;Specificity;Splenocyte;Surface;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;Therapy Clinical Trials;transcriptome;transcriptomics;Treatment Efficacy;Xenograft Model

PROJECT_TITLE: Immunomodulatory effects of desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) in mucosal pemphigus vulgaris


NIH_SPENDING_CATS: Data Science;Social Determinants of Health

PROJECT_TERMS: Address;Affect;base;Behavioral Research;Biomedical Research;Biometry;Businesses;career development;Clinical Research;Collaborations;Communication;Communities;community collaboration;community engagement;Consultations;Core Facility;Data Science;design;Development;Diagnosis;Direct Costs;Discipline;disorder prevention;Effectiveness;effectiveness evaluation;effectiveness research;empowerment;ethnic minority population;Evaluation Research;experience;Extramural Activities;Faculty;Funding;Grant;Hawaii;Health Disparities Research;health disparity;Histopathology;innovation;Institution;Leadership;Link;Marketing;Mentors;minority health;minority health disparity;Modernization;Needs Assessment;outreach;Pilot Projects;Policies;Procedures;Productivity;programs;Publications;Reduce health disparities;Regulation;Research;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;satisfaction;Science;Scientist;Services;Stream;Structure;Students;success;Technical Expertise;tool;Training;Training and Education;Training Programs;Underrepresented Minority;United States National Institutes of Health;Work


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative The administrative supplementary aims to develop a true 3D quantitative anthropomorphic head/brain phantom Use cases include: protocol development for research clinic and industry, system calibration validation and Q/A for morphology and qMRI, MRI receive and transmitter coil development, Image reconstruction performance validation. Testing, validation and Q/A of automatic prescription methods.

PI_NAMEs: ARIAS, ANA CLAUDIA;LUSTIG, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TITLE: Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Emerging data demonstrate that most people with epilepsy are more likely to have seizures at certain times of the day. However, the mechanisms that underlie these daily rhythms in seizures remain unclear. This proposal seeks to leverage the power of the fly model system to identify underlying cellular and circuit mechanisms, with the end goal of identifying novel therapeutic targets and improving our ability to predict seizure occurrence.

PI_NAMEs: CUDDAPAH, VISHNU ANAND (contact)

PROJECT_TITLE: Regulation of seizure timing by circadian rhythms and sleep


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This supplement project aims to develop and apply immuno-serological assays and single-cell spatial omics assays to investigate the COVID 19 vaccine response in patients with hematologic malignancies and autoimmunity. The findings will improve our understanding of innate and adaptive immune mechanisms in COVID-19 vaccination and provide insights for how to prevent or intervene in future infectious disease pandemic or epidemic, in particular, for protecting patients with compromised immunity.

PI_NAMEs: FAN, RONG  (contact);HALENE, STEPHANIE

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Antigens;arm;Autoimmune Diseases;Autoimmunity;Award;Basophils;Biological Assay;Biopsy Specimen;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Communicable Diseases;COVID-19 monitoring;COVID-19 vaccination;COVID-19 vaccine;Data;data integration;Dendritic Cells;Dermis;Development;Environment;Epidemic;Epidermis;Future;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoietic Neoplasms;Image;Immune;Immunity;Immunofluorescence Immunologic;Immunologics;immunoreaction;improved;Informatics;Injections;insight;mRNA sequencing;pandemic disease;Patients;Peripheral;prevent;response;Role;Sampling;SARS-CoV-2 spike protein;Serology;Serum;Site;skin biopsy;Skin Tissue;Slide;Tissues;unvaccinated;Vaccinated;vaccine response;Vaccines

PROJECT_TITLE: Immuno-Serological Assays for Monitoring COVID19 in Patients with Hematologic Malignancies


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD/ADRD). Yet nearly half of midlife adults (48%) do not meet national physical activity guidelines. The purpose of this mechanistic trial is to identify effective goal setting techniques to enhance psychosocial processes of self-regulation for the successful promotion of PA and adherence to national PA guidelines among midlife adults, with the long-term goal of reducing AD/ADRD risk.

PI_NAMEs: JOSEPH, RODNEY ;MAXFIELD, MOLLY  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Accelerometer;Adherence;Adult;adult obesity;Age;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;arm;Behavior;behavior change;Biological Markers;Blood Pressure;Body mass index;Brain-Derived Neurotrophic Factor;Cardiometabolic Disease;Caregivers;Cholesterol;Cognitive;cognitive function;Control Groups;daily functioning;dementia risk;disorder risk;Dose;Dyslipidemias;Ethnic Origin;executive function;experience;Family;Feedback;fitbit;follow-up;Glucose;Goals;group intervention;Guidelines;Health Campaign;Health Personnel;Healthcare Systems;Heterogeneity;High Density Lipoproteins;Hypertension;Impairment;improved;Individual;Informal Social Control;Insulin;insulin sensitivity;Intervention;intervention delivery;intervention refinement;Language;Life Style;lifestyle factors;Literature;Low-Density Lipoproteins;Manuals;Measures;Mediating;Mediator;Memory;Mental Depression;middle age;Monitor;Nerve Degeneration;neurogenesis;neuroinflammation;Obesity;Outcome;Oxidative Stress;Participant;Pathogenesis;Phase;Physical activity;Pilot Projects;Plasma;Process;processing speed;Protocols documentation;psychosocial;Public Health;Race;Randomized;randomized trial;Recommendation;Reporting;Research;Research Personnel;response;Risk;Risk Reduction;Self Determination;Self Efficacy;sex;successful intervention;Symptoms;synaptogenesis;tau-1;Tauopathies;Techniques;Testing;theories;Very low density lipoprotein;Work

PROJECT_TITLE: Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-of-Concept Trial


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Microbiome;Pulmonary Fibrosis;Rare Diseases;Sarcoidosis

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative Pulmonary sarcoidosis has unknown cause and severe manifestations significantly impair quality of life and can result in lung transplant and death. Exposure to bacterial and fungal products is thought to play a role, yet there is great need to understand why some patients with pulmonary sarcoidosis develop severe lung disease. We will measure how residential exposure to bacteria and fungi contribute to severe sarcoidosis lung disease which will eventually lead to optimal treatment strategies, such as household environmental remediation.

PI_NAMEs: GERKE, ALICIA  (contact);PEZZULO, ALEJANDRO ANTONIO

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Affect;African American population;Agriculture;Air Pollution;airway epithelium;Animal Model;Antibodies;Antigens;Bacteria;Biological Markers;Biopsy;Bronchoalveolar Lavage Fluid;Carbon Monoxide;Cell Adhesion;Cell Wall;Cells;Cessation of life;Chest imaging;chronic inflammatory lung disease;cohort;Collecting Cell;Coughing;cytokine;Data;diagnostic biomarker;Diffusion;Disease;Disease Outcome;Dyspnea;Educational workshop;Elderly;Endotoxins;Environment;Environmental Exposure;epidemiologic data;Epidemiology;Epithelial Cells;Epithelium;experience;Exposure to;Fibrosis;fibrotic lung disease;fungal microbiota;fungus;Genetic Predisposition to Disease;Goals;Granuloma;Granulomatous;Granulomatous disease;Household;Human;Immune;Immune response;Impairment;In Vitro;Inflammation;Inflammatory;inflammatory marker;injured airway;Liquid substance;Lung;Lung Diseases;Lung Transplantation;lymph nodes;Measurement;Measures;mildew;Molds;Morbidity - disease rate;mortality;mycobiome;National Heart, Lung, and Blood Institute;novel;optimal treatments;Pathogenicity;Patients;Peripheral;peripheral blood;Persons;Phenotype;polyglucosan;Population;Predisposition;prevent;progression marker;protein expression;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Sarcoidosis;Quality of life;recruit;remediation;Reporting;Research;residence;response;Role;Sarcoidosis;Serum;Severities;Severity of illness;Symptoms;Techniques;Testing;Thoracic Radiography;transcriptomics;treatment strategy;Uveitis;Vital capacity;Woman;Work

PROJECT_TITLE: The Role of Residential Bioaerosol Exposure in Pulmonary Sarcoidosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Palliative Care;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: Los Angeles

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Elder mistreatment affects approximately one in ten older adults, worsening their health, wellbeing, and mortality, with serious costs to families, health care systems, and society making it one of the most pressing public health problems for older adults in the U.S. For people living with dementia, rates approach 50%, with risk factors that arise from a complicated and interwoven set of characteristics distributed among people and circumstances. Through the proposed study, we will develop and implement a risk assessment screen and an intervention in primary care settings focused on family care partners/caregivers that will lead to the primary prevention of elder mistreatment in this vulnerable population.

PI_NAMEs: OLSEN, BONNIE JEAN (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Alzheimer's disease related dementia;American;Behavior;Behavioral;brief intervention;caregiver interventions;Caregivers;caregiving;Caring;Categories;Cessation of life;Characteristics;Clinic;Clinic Visits;clinical care;community advisory board;cost;County;Cultural Sensitivity;Data;Dementia;Dementia caregivers;design;Detection;Development;Education;effectiveness testing;efficacy testing;Elder Abuse;Elder abuse prevention;emotional abuse;Ensure;ethnic diversity;evidence base;Family;Family Caregiver;feasibility testing;Feedback;financial exploitation;Focus Groups;follow-up;Geriatric Assessment;Goals;Health;Healthcare Systems;Home;improved;indexing;Individual;Intervention;intervention effect;Intervention Studies;intimate partner violence;Los Angeles;Managed Care;Measures;Methods;modifiable risk;Monitor;Morbidity - disease rate;mortality;neglect;novel strategies;older adult;Outcome;Outcome Measure;Participant;Patients;person centered;Personal Satisfaction;Persons;Phase;physical abuse;Population;Preventive service;Primary Care;primary care clinic;primary care setting;primary care visit;primary medical care;primary outcome;Primary Prevention;Protocols documentation;Provider;Public Health;racial diversity;Randomized;Randomized, Controlled Trials;Reporting;Research;Respondent;Risk;Risk Assessment;Risk Factors;Risk Reduction;Sampling;Schedule;screening;Screening procedure;Self Care;Self Perception;service utilization;Sexual abuse;Site;Societies;Spanish/English;Surveys;Target Populations;Technology;three-arm study;Time;tool;United States Centers for Medicare and Medicaid Services;United States Preventative Services Task Force;Validation;Victimization;Visit;Vulnerable Populations;web site

PROJECT_TITLE: Risk Screening & Primary Prevention of Elder Abuse in People Living with Dementia


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Sexual conflict occurs when males and females have divergent strategies to reach their respective fitness optima, and is thought to drive morphological innovations, behaviors, and even contribute to speciation. However, the genes involved remain unknown. My proposed research will define the generality of sexual conflict-driven new gene evolution and how these new genes facilitate sex-specific functions to mediate or resolve sexual conflict.

PI_NAMEs: ARSALA, DEANNA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Age;Alternative Splicing;Animals;Behavior;Biological Assay;Candidate Disease Gene;Case Study;cell type;Cells;Conflict (Psychology);conflict resolution;CRISPR/Cas technology;Data Set;Development;Disadvantaged;DNA;Drosophila genus;Drosophila melanogaster;Evolution;Female;Fertility;fitness;fly;Gene Duplication;Gene Expression;gene function;Genes;Genetic;genetic approach;genetic association;genetic evolution;Genetic Materials;Genome;genome editing;Goals;Human;innovation;Insecta;Knock-out;Laboratories;loss of function mutation;male;male fertility;Mediating;Morphology;mutant;novel;Organism;Outcome;paralogous gene;Pathway interactions;Pattern;Publishing;Reproduction;reproductive;Research;Resolution;reverse genetics;RNA;Role;sex;Sex Bias;sex determination;sexual dimorphism;single-cell RNA sequencing;Technology;Testing;Testis;Time;Tissues;trait;transcriptome sequencing;transcriptomic profiling;Work

PROJECT_TITLE: Assessing the generality of sexual conflict in new gene evolution in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Repeated cycles of binge alcohol intoxication and withdrawal are associated with impaired social behaviors, compounding interpersonal problems associated with alcohol abuse and hastening the progression to alcohol use disorder (AUD). Unfortunately, few treatment options are currently available that specifically address the social symptoms of alcohol abuse. This study will employ a rodent model of binge alcohol consumption to elucidate serotonergic mechanisms of alcohol’s deleterious effect on social behavior, with an eye toward developing new treatments for AUD.

PI_NAMEs: FLANIGAN, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 3-Dimensional;Abstinence;Acute;Address;Affective;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Award;Back;Behavior;Behavioral;binge drinking;Brain;Buffers;Cell Nucleus;Cell Physiology;cell type;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;COVID-19 pandemic;Darkness;Data;design;Development;drinking;Electrophysiology (science);Equilibrium;experience;experimental study;Female;Fiber;Foundations;Future;G alpha q Protein;Gene Expression;Generations;Genetic;genetic manipulation;Habenula;Heavy Drinking;hindbrain;impaired driving performance;Impairment;in vivo;Individual;knock-down;Lateral;Medial;Mediating;Modeling;Molecular;Mood Disorders;Mus;negative emotional state;neurobiological mechanism;neuronal excitability;Neurons;neuroregulation;novel;overexpression;patch clamp;Patients;Pattern;Persons;Phase;Photometry;Physiological;Physiological Adaptation;Physiological Processes;Physiology;prevent;programs;receptor;receptor expression;Receptor Signaling;Recording of previous events;Regulation;Relapse;Research;Research Personnel;response;Rewards;Risk;Rodent;Rodent Model;Role;Serotonin;serotonin receptor;sex;Signal Transduction;skills;social;Social Behavior;Social Behavior Disorders;social deficits;Social Functioning;Social Interaction;Social Problems;Social support;Stimulus;Substance Use Disorder;Symptoms;System;targeted treatment;Technical Expertise;Techniques;Testing;tool;Training;transcriptomics;translating ribosome affinity purification and RNA-sequencing;translatome;Treatment outcome;Viral;virus genetics;Woman

PROJECT_TITLE: Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptors


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PUBLIC HEALTH RELEVANCE Cyclic GMP synthesis in photoreceptors enables vision. Abnormalities in the cGMP synthesis impair rod and cone vision and cause congenital retinal diseases. In this application, we seek better understanding of the molecular mechanisms regulating cGMP synthesis in biological function and disease of photoreceptors. This knowledge can help understand the origins of congenital blindness and design strategies for their treatment.

PI_NAMEs: DIZHOOR, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Affinity Chromatography;atrial natriuretic factor receptor A;Binding;Biochemical Process;Biological Assay;Biological Process;Biology;Blindness;British Columbia;Calcium;Cattle;Cessation of life;cGMP production;Clinical Trials;Collaborations;Complex;Cryoelectron Microscopy;Cyclic GMP;design;Detergents;Development;Disease;disease-causing mutation;Engineering;Eye diseases;Functional disorder;gene therapy;Genetic;genetic regulatory protein;Goals;guanylate;Guanylate Cyclase;guanylate cyclase activating protein;Human;Hyperactivity;Impairment;In Vitro;in vivo;Integral Membrane Protein;Isoenzymes;Knowledge;Laboratories;Link;Medical;Membrane;Methods;Mission;Molecular;Molecular Biology;Molecular Genetics;Molecular Structure;Monoclonal Antibodies;mouse genetics;mouse model;Mus;mutant;Mutation;Peptides;Periodicity;photoreceptor disc;Photoreceptors;Phototransduction;Physiological;Physiology;prevent;Process;Protein Biochemistry;protein protein interaction;Proteins;public health relevance;Recombinants;Regulation;Research;Research Design;Research Support;Retina;Retinal Degeneration;Retinal Diseases;Rod Outer Segments;Role;Signal Transduction;Source;Structure;Study models;temporal measurement;Testing;Therapeutic;three dimensional structure;trafficking;Transgenic Mice;Translating;Universities;Variant;Vertebrate Photoreceptors;Vision;Vision Disorders

PROJECT_TITLE: Regulation of Cyclic GMP Synthesis in Photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]