NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative: The ability to adapt behavior in a context-dependent manner is critical for survival in a dynamic world. This project will explore the cell-type-specific microcircuitry in the medial prefrontal cortex responsible for adaptive decision making in response to changing reward contingencies, and how the modulation of these neurons by dopamine impacts behavioral flexibility. The findings of this study will provide a thorough structural understanding of how a key brain region driving cognitive flexibility functions, providing a template by which to further explore how these mechanisms may be disrupted in various neurological disorders.

PI_NAMEs: VORMSTEIN-SCHNEIDER, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Adverse effects;Animals;Area;autism spectrum disorder;Automobile Driving;Award;Behavior;Behavioral;behavioral outcome;Behavioral Paradigm;Brain region;Calcium;career;cell type;Cells;Cognitive;cognitive rigidity;collaborative environment;Communities;CRISPR/Cas technology;debilitating symptom;Decision Making;Development;dimension reduction;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;dopaminergic neuron;Elements;experimental study;flexibility;Future;Genetic;genetic manipulation;Goals;Image;Impairment;insight;Interneurons;Knock-out;Knowledge;Label;laboratory experience;Measures;Medial;Mediating;member;Mentors;Mus;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;Neurotransmitters;optogenetics;Outcome;Output;Performance;Population;Prefrontal Cortex;Proteins;receptor;Recording of previous events;Research;Resources;response;Rewards;Role;Schizophrenia;Scientist;Signal Transduction;System;Task Performances;Techniques;Testing;Therapeutic;tool;Training;Transgenic Mice;two-photon;Universities;Update;Vasoactive Intestinal Peptide;Work

PROJECT_TITLE: Exploring the Contribution of Distinct mPFC Cell-Types to the Encoding of Decision-Making Outcome


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Sleep Research;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Prenatal alcohol exposure (PAE) can cause a wide range of detrimental effects, such as neurobehavioral and functional impairments, that create challenges for caregivers, schools, and society at large. Individuals with PAE as well as their caregivers often report sleep problems, yet little is known about how PAE influences sleep in children and adolescents. This project will examine circadian rhythmicity in children and adolescents with PAE as well as categorize age-related differences in sleep, cognition, and behavior in adolescents with PAE, and these findings will inform the design of future interventions targeting sleep disturbances within this population.

PI_NAMEs: SOJA, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Affect;Age;age difference;age group;age related changes;aged;alcohol consumption during pregnancy;alcohol exposure;Arousal;autism spectrum disorder;Behavior;behavior measurement;Behavioral;behavioral impairment;Biological;Brain;Caregivers;Categories;Characteristics;Child;circadian;Circadian Dysregulation;Circadian Rhythms;clinically significant;Cognition;Cognitive;cognitive development;cognitive function;critical developmental period;design;Development;differential expression;effective intervention;Emotional;emotional functioning;Endocrine;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional disorder;Functional impairment;Future;Genes;gut microbiota;Health;human old age (65+);Immune;Impaired cognition;improved;Individual;Intervention;life span;Mediating;Melatonin;modifiable behavior;neurobehavioral;Neurodevelopmental Disorder;Outcome;Parasomnias;Periodicity;physical impairment;Physiological;poor sleep;Population;Pre-Clinical Model;Pregnancy;Prevalence;Problem behavior;Psychopathology;Psychophysiology;Public Health;Quality of life;Reporting;Research;Resistance;Schools;Sleep;Sleep Apnea Syndromes;Sleep Architecture;sleep behavior;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;Sleeplessness;Societies;Symptoms;System;Time;United States;Woman;Youth

PROJECT_TITLE: Sleep Characteristics in Children and Adolescents with Prenatal Alcohol Exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening multi-system disease that is grossly underdiagnosed and undertreated, particularly in underserved groups. In this project, we will identify predictors of delayed diagnosis of ATTR-CM, estimate the effect of delayed diagnosis on patient outcomes, and retrospectively assess the effect of implementation of an echo-based deep learning algorithm for the detection of ATTR-CM on diagnostic disparities. This project will serve to identify groups that are at risk of delayed diagnosis nationally and evaluate an intervention to improve timely diagnosis of this high morbidity and high mortality disease.

PI_NAMEs: SPENCER BONILLA, GABRIELA M. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;African American;Age;Algorithms;Amyloid;Artificial Intelligence;Black American;Black Populations;Cardiac;cardiac amyloidosis;Cardiology;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;career;Caucasians;Cessation of life;Characteristics;Chronic;Clinical;clinical diagnosis;County;Data;Data Set;data warehouse;Databases;Dedications;deep learning algorithm;demographics;Detection;Diagnosis;Diagnostic;Disease;Disease Progression;Disparity;Disparity in diagnosis;Diuretics;Dose;Early Diagnosis;Echocardiography;Ensure;Equity;Fee-for-Service Plans;Geographic Factor;Goals;health equity;Health Services;Healthcare;Healthcare Systems;Heart failure;High Prevalence;Homelessness;Hospital Administration;Hospitalization;human old age (65+);Image;implementation evaluation;improved;Inequality;Inequity;Inpatients;Institution;Intervention;Laboratories;Life;Literature;Logistic Regressions;machine learning algorithm;machine learning model;Medical;Medicare;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;Mutation;Neighborhoods;novel;Outcome;Outpatients;Pathogenicity;Patient Care;patient screening;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacy facility;Populations at Risk;Prealbumin;Race;Research Personnel;Risk;screening;service intervention;sex;skills;social;sociodemographics;System;Testing;Time;Underserved Population;United States Department of Veterans Affairs;Veterans Health Administration

PROJECT_TITLE: Toward Equity in ATTR Cardiomyopathy Diagnosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The developing brain becomes active before sense organs and their connections to the brain are mature enough to provide input. Even though this spontaneous developmental activity happens in many parts of the brain, outside of very specialized cases, we do not know how it helps in building a healthy, functioning nervous system, or whether changes in the activity leads to neurodevelopmental disorders. Using the much simpler brain of the fruit fly, I will look for the nerve cells that bring about developmental activity so that we can change how they work and begin to study the effects of altering the activity on behaviors such as sleep and learning-and-memory.

PI_NAMEs: SUAREZ, SASSAN LEO (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Adult;Area;Attention;Automobile Driving;Behavior;Behavioral;Biological Metamorphosis;Biology;Brain;Brain region;Cations;cell type;Cells;Communication;Complement;Complex;cost;Development;Developmental Process;Disparate;Drosophila genus;Drosophila melanogaster;emerging adult;Exhibits;Eye;fly;Follow-Up Studies;Future;Genetic;genetic approach;Health;Human;improved;in utero;Individual;insight;Ion Transport;knock-down;Label;Laboratory Finding;Lead;Learning;Mammals;Memory;Modeling;Molecular Genetics;Morphogenesis;mutant;Nervous System;Nervous System Physiology;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neuropeptides;neurophysiology;Neurosciences Research;Optic Lobe;Pattern;Peptide Receptor;Peptide Transport;Phase;Population;Process;Proliferating;receptor;Reporting;Retina;Retinal blind spot;RNA Interference;Role;Running;Science;Sense Organs;Sensory;sensory input;Sensory Process;sensory stimulus;sensory system;Shapes;Signal Pathway;Site;Sleep;spatiotemporal;Stereotyping;Stimulus;Structure;Synapses;synaptogenesis;System;Techniques;Testing;Thalamic structure;Visual;Visual System;Visualization;Work

PROJECT_TITLE: Identifying the cells and circuits driving stimulus-independent activity throughout the developing Drosophila brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative of Parent R01 “Synergistic killing of bacterial pathogens by histones” (1R01AI163196)  The effective treatment of bacterial infections of skin, deep soft tissues and wounds continues to be a major unmet healthcare challenge, especially in patients whose antimicrobial responses are compromised by underlying diabetes. The proposed work seeks to establish a new class of antimicrobials, inspired by immune cells, that are synergistic through the combination of histones with agents that target the outer surface of bacteria. The successful outcome of this work would provide fundamental insight into a novel antimicrobial mechanism and produce important pre-clinical data for the development of new therapeutics that treat skin, soft tissue, and wound infections.

PI_NAMEs: SIRYAPORN, ALBERT  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;antimicrobial peptide LL-37;Attention;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bactericide;Bacteriology;Biology;Biophysics;cathelicidin;cathelicidin antimicrobial peptide;Cell Wall;Cells;Cellular biology;Cessation of life;Chemicals;Chronic;chronic wound;combat;Communities;Cryoelectron Microscopy;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;DNA;effective therapy;Engineering;experimental study;extracellular;Fiber;Foundations;Gene Expression;Goals;Grant;health care settings;Healthcare;Histone H2A;histone modification;Histones;Human;human pathogen;Immobilization;Immune;Immunology;In Vitro;in vivo;Infection;Infectious Skin Diseases;inhibitor;innovation;insight;Interdisciplinary Study;Malignant Neoplasms;Measures;Membrane;methicillin resistant Staphylococcus aureus;microbial;microbial community;Modeling;Modernization;Modification;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;neutrophil;next generation;non-diabetic;non-healing wounds;novel;novel strategies;novel therapeutics;Outcome;Parents;pathogen;pathogenic bacteria;Pathway interactions;Patients;Peptidoglycan;pre-clinical;Proliferating;Pseudomonas aeruginosa;ramoplanin;Reporting;Resistance;resistant strain;response;scaffold;Shapes;Skin;skin wound;soft tissue;Soft Tissue Infections;Standardization;Staphylococcus aureus;Surface;synergism;targeted agent;Testing;Therapeutic;uptake;Work;wound;Wound Infection


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: SEATTLE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Vestibular hair cells sense head motions and help us to navigate our environment purposely, without nausea, disorientation, or injury. Humans lose vestibular hair cells as we age or are exposed to ototoxins, resulting in significant declines in our quality of life. The proposed studies seek to understand how vestibular hair cells develop the specialized structures that enable them to function and how they maintain them in adulthood, which will give scientists better insights into how to regenerate hair cells that restore vestibular function.

PI_NAMEs: STONE, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Adult;Age;Binding;Binding Sites;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;conditional knockout;debilitating symptom;Development;Disorientation;Dizziness;Elements;Endowment;Enhancers;Environment;Epigenetic Process;Equilibrium;Exposure to;Frequencies;Functional Regeneration;Future;Gene Deletion;gene function;gene regulatory network;gene repression;Genes;Genetic;Genetic Transcription;Growth;Hair;hair cell regeneration;Hair Cells;Head;Human;In Vitro;Individual;Injury;insight;Knowledge;Laboratories;Length;Lesion;Ligands;macula;Maintenance;Mammals;Modeling;Molecular;Morphology;Motion;Motor;Multiomic Data;multiple omics;Mus;Natural regeneration;Nausea;nerve supply;Neurons;novel;Organ;Organelles;ototoxin;overexpression;Phenotype;Population;postsynaptic;preservation;Property;Quality of life;receptor;repaired;Reporter;Repression;Rodent;Scientist;Sensory;Shapes;single nucleus RNA-sequencing;Specific qualifier value;Stimulus;Structure;Synapses;Synaptic Transmission;System;Testing;Thick;Thinness;transcription factor;Type I Hair Cell;Type II Hair Cell;Utricle structure;Vertigo;Vestibular dysfunction;Vestibular function;Vestibular ganglion;Vestibular Hair Cells;vestibular system;vestibulo-ocular reflex;Work

PROJECT_TITLE: Vestibular Hair Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative It is imperative to identify new therapeutic targets in ccRCC, which is resistnt towards radio or chemotherapy. Here we provide evidence for the noncanonical role of VHL on regulating m6A modification and gene expression, which uncovers new mechanistic insight important in kidney tumorigenesis. This study, if successful, will set the foundation for therapeutic intervention targeting the VHL-Mettl3/14-m6A signaling axis in ccRCC.

PI_NAMEs: ZHANG, QING  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3-Dimensional;Accounting;Adenosine;Agar;Aggressive behavior;Binding;Cancer Cell Growth;Cancer Patient;cancer therapy;cell growth;Cell Nucleus;Cell Proliferation;Cessation of life;chemotherapy;Clear cell renal cell carcinoma;Clinical;Complex;Cytoplasm;cytotoxic;Data;Development;Disease;Epithelium;Event;Foundations;Gene Expression;Genes;Growth;HIF1A gene;Hypoxia Inducible Factor;in vivo;Incidence;Inflammation;inhibitor;insight;Kidney;kidney cell;Link;Malignant Neoplasms;Mediating;Mesenchymal;Messenger RNA;Methylation;Modification;Molecular;new therapeutic target;novel;overexpression;Pathologic Processes;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Phosphatidylinositols;Phosphotransferases;Physiological;Play;Primary Neoplasm;Prognosis;programs;protein complex;Proteins;Proto-Oncogene Proteins c-akt;PTK2B gene;Radiation therapy;Reader;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Resistance;RNA immunoprecipitation sequencing;RNA Stability;Role;Signal Pathway;Signal Transduction;Specimen;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Microarray;transcriptome;transcriptome sequencing;Treatment Efficacy;trend;tumor;Tumor Cell Invasion;tumor growth;Tumor Suppressor Proteins;tumorigenesis;ubiquitin-protein ligase;Up-Regulation;VHL protein;Xenograft Model;Xenograft procedure

PROJECT_TITLE: New Von Hippel Lindau (VHL) tumor suppressor signaling in renal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-D (02)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Evidence suggests a growing health disparity in mental health, specifically an increase in depression and anxiety among Latinx young adults, with fear of deportation contributing to this disparity. The goal of the proposed research is to expand health disparity and discrimination research among Latinxs by assessing the multi-domain effects of fear of deportation on systemic inflammation (biological domain) and mental health outcomes (i.e., depression and anxiety; behavioral domain), and examine related multi-level risk and protective factors. By exploring the biological mechanisms explaining how structural racism “gets under the skin” and identifying related risk and protective factors, this study can inform the development of targeted interventions and policies aimed at reducing health disparities in minoritized populations.

PI_NAMEs: BAUTISTA, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Acculturation;Address;Affect;American;Anxiety;Area;Automobile Driving;Behavioral;Biological;Biological Process;biopsychosocial;career;Child;Clinical;Communities;cytokine;Development;Discrimination;Disease;Disparate;Disparity;experience;Family;Family member;Fright;Future;Generations;Goals;Health;health determinants;health disparity;Health Promotion;Household;Immigrant;Immigration;improved;Individual;Inflammation;Inflammatory;innovation;Intervention;Knowledge;Latina;Latinx;Latinx population;Legal Status;Link;Literature;Mediating;Mental Depression;Mental Health;Mexican;Minority Groups;Modeling;National Institute on Minority Health and Health Disparities;novel;Outcome;Parents;Pathway interactions;perceived discrimination;Policies;Politics;Population;Predisposition;Prevalence;promote resilience;protective factors;Psychological Stress;Psychology;Questionnaires;recruit;Reduce health disparities;Religiosity;Research;resilience;Risk Factors;Role;saliva sample;Scientist;Skin;skin color;social culture;Stress;Structural Racism;Students;Surveys;Symptoms;systemic inflammatory response;Testing;Time Factors;Training;Training Support;United States;university student;Well in self;young adult;Youth

PROJECT_TITLE: A multi-level study of the link between fear of deportation and mental health in Latinx young adults: The role of systemic inflammation and related risk and protective factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Type 2 Diabetes (T2D) is a major health priority within the VA. More than 24% of Veterans have T2D, twice the national average. There is an increasing population of female veterans in the VA in the premenopausal age range. Premenopausal women with T2D have poorer health-related outcomes compared with age-matched men with T2D such as a 3.5 times increase in cardiovascular disease (CVD) mortality. CVD mortality is predicted by aerobic power, and skeletal muscle bioenergetics is a primary contributor to aerobic power. Estrogen (E2) is generally considered supportive of skeletal muscle bioenergetics, however, mounting evidence suggests that the biological context in which E2 acts, such as T2D, is critical to the specific targets of E2 action. Understanding the mechanisms by which T2D impairs E2 support of skeletal muscle bioenergetics will identify potential molecular targets for clinical therapies to improve the health of premenopausal women with T2D.

PI_NAMEs: SCALZO, REBECCA L (contact)

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;5'-AMP-activated protein kinase;Address;Aerobic;Aerobic Exercise;Affect;Age;aged;Animal Model;antagonist;Attenuated;Bioenergetics;Biogenesis;Biological;Cardiovascular Diseases;Cell Culture Techniques;Clinical;clinically relevant;clinically significant;Cyclic AMP;Data;design;Diabetes Mellitus;diabetic;Diet;Disparity;energy balance;Environment;Estradiol;estrogen disruption;Estrogens;Exercise;exercise capacity;experimental study;Exposure to;Fat-Restricted Diet;Female;functional status;Goals;Health;Health Priorities;High Fat Diet;Impairment;improved;In Vitro;in vivo;Incidence;inhibitor;insight;Knowledge;knowledge base;Measures;Mediating;men;Mentors;Methods;military veteran;Mitochondria;Molecular Target;mortality;Mus;Muscle;Muscle Fibers;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;Outcome;Ovariectomy;Pathway interactions;Physiological;PIK3CG gene;Population;PPAR gamma;pre-clinical;Premenopause;Prevalence;Primary Cell Cultures;Process;programs;Rattus;Reporting;reproductive;Research Personnel;Respiration;response;Role;Scientist;sex;Sex Differences;Signal Pathway;Signal Transduction;Skeletal Muscle;skills;sugar;System;Testing;Training;training opportunity;Veterans;VO2max;Wistar Rats;Woman;Women's Health

PROJECT_TITLE: The Interaction of Diabetes and Estrogen on Skeletal Muscle Bioenergetics


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Very little is known regarding the underlying reasons why the rate of colorectal cancer has been increasing among those <50 years of age and how the patterns of screening might have changed over time in this age group. This study aims to understand the risk factors associated with early-onset colorectal cancer and factors that may explain differences in screening patterns across various geographic regions. Results from this study may be utilized to help identify individuals who are at a higher risk for early-onset colorectal cancer or regions that have low levels of screening, so interventions could be designed and implemented to reduce disease risk and improve screening.

PI_NAMEs: SIDDIQUE, ARFAN  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Adoption;Age;age group;Age Years;aged;Air;American;American Cancer Society;aspirate;Atlases;Behavioral;beneficiary;Birth;Birth Records;Birth Weight;Blue Cross;Blue Shield;California;cancer diagnosis;cancer epidemiology;career;Caring;Censuses;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic Disease;Classification;cohort;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;contextual factors;Country;COVID-19 pandemic;Data;data registry;Databases;design;disorder risk;Disparity;Early identification;early onset;early onset colorectal cancer;early screening;Encapsulated;Enrollment;Environmental Risk Factor;epidemiology study;Etiology;Event;Excision;Feces;Gastroenterologist;gastrointestinal;Genetic;Geographic Information Systems;Geographic Locations;Geography;Guidelines;Health;Health Services Research;Health Status;Healthcare;high risk;high risk population;Hospital Referrals;improved;Incidence;Individual;innovation;Insurance;Interruption;Intervention;Knowledge;Life;Life Style;lifestyle factors;Light;Link;Malignant Neoplasms;Maternal Age;Menstruation;Methodology;Minority;Modeling;multidisciplinary;National Cancer Institute;Neighborhoods;neoplasm registry;Nested Case-Control Study;Oncology;Onset of illness;Outcome;Pathology;Patients;Pattern;Persons;Physical environment;Population;population based;pre-doctoral;Predisposition;Prevalence;Prevention strategy;Preventive service;Primary Prevention;Probability;Provider;Public Health;Recommendation;Research;Resources;response;Risk;Risk Assessment;Risk Factors;Sample Size;Sampling;Science;screening;screening guidelines;Secondary Prevention;social;Social Environment;sociodemographics;Socioeconomic Status;spatiotemporal;statistics;Symptoms;Testing;therapy design;Time;Time Series Analysis;Time trend;Training;United States;United States Environmental Protection Agency;United States Preventative Services Task Force;Update;uptake;Variant

PROJECT_TITLE: Examining Early Life Risk Factors and Patterns of Screening for Early-Onset Colorectal Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE During brain development, neural progenitor cells generate a diverse array of cell types, including oligodendrocytes, the myelinating glial cell type of the central nervous system. The purpose of this research is to use the mouse embryonic neocortex as a system to understand the cell signaling pathways and epigenetic mechanisms that specify neural progenitors towards an oligodendrocyte fate. Completion of this work will significantly contribute to a better understanding of oligodendrocyte development and provide insight on novel therapeutic strategies to treat diseases associated with oligodendrocyte dysfunction and demyelination, such as multiple sclerosis, leukodystrophies, and many peripheral pathologies.

PI_NAMEs: TRAN, LUULI  (contact)

PROJECT_TERMS: ATAC-seq;Axon;Brain;cell fate specification;cell type;Cells;Central Nervous System;Chromatin;cognitive disability;Competence;Data;Data Set;Defect;Demyelinations;Development;Disease;Dorsal;Embryo;Embryonic Development;Epigenetic Process;Equilibrium;excitatory neuron;Exposure to;extracellular;Functional disorder;Gene Expression;genetic approach;genetic manipulation;Genetic Transcription;in vivo;Injury;insight;Knowledge;Lead;leukodystrophy;Mediating;Methods;Modeling;Molecular;motor impairment;Multiple Sclerosis;Mus;Myelin;myelination;Neocortex;neocortical;Nerve Degeneration;nerve stem cell;Nervous System Disorder;neural circuit;neurogenesis;Neuroglia;Neurons;Neurophysiology - biologic function;notch protein;Notch Signaling Pathway;novel;novel therapeutic intervention;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Pathology;Pathway interactions;Pattern;Peripheral;pharmacologic;Positioning Attribute;precursor cell;Production;progenitor;Prosencephalon;Proteins;Regulation;Research;response;Role;SHH gene;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;smoothened signaling pathway;Sonic Hedgehog Pathway;Specific qualifier value;Spinal Cord;stem cell fate specification;System;Testing;tool;transcription factor;Work

PROJECT_TITLE: The Role of Notch Signaling in Shh-mediated Oligodendrocyte Fate Specification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE PARP16 is emerging as a novel cancer driver in ovarian and lung cancer, however, the role of PARP16 enzymatic activity in cancer is not fully understood. We have recently developed the first potent and selective covalent PARP16 inhibitor called DB008 and have observed that the non-catalytical activity of PARP16 is more important for ovarian and lung cancer growth than PAR16 enzymatic activity. The goal of this proposal is to develop new chemical tools based on DB008 that will validate PARP16 as an oncology drug target, provide a lead preclinical candidate, and identify PARP16 interactors in order to understand the mechanism of action of PARP16 in cancer.

PI_NAMEs: BEJAN, DANIEL  (contact)

PROJECT_TERMS: Acrylamides;Active Sites;Adenosine Diphosphate Ribose;ADP ribosylation;Alkynes;Automobile Driving;Binding;Binding Proteins;Biological Assay;Biology;cancer cell;cancer subtypes;Cell Death;Cell Survival;Cells;Chemicals;Chemistry;Chimeric Proteins;Comparative Study;cross reactivity;crosslink;Cysteine;Diazomethane;Disease;drug candidate;Drug Targeting;Endoplasmic Reticulum;Environment;Enzymes;Exhibits;Family;FDA approved;Genetic;Goals;Growth;Human;Hydrogen Peroxide;inhibitor;insight;interest;knock-down;Knock-out;Label;Lead;Length;Light;Link;lung cancer cell;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;member;Methods;nanomolar;new therapeutic target;Nicotinamide adenine dinucleotide;novel;Oncology;paralogous gene;Phenotype;Phosphotransferases;Physiology;Poly(ADP-ribose) Polymerase Inhibitor;pomalidomide;Post-Translational Protein Processing;pre-clinical;preservation;Process;Protac;Protein Biosynthesis;protein degradation;protein protein interaction;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;Research Personnel;Role;Signal Transduction;small cell lung carcinoma;small molecule;Stress;tandem mass spectrometry;Technology;Testing;tool;Translations;tumor progression;Ubiquitin;ubiquitin-protein ligase;ultraviolet irradiation;Ultraviolet Rays;Western Blotting

PROJECT_TITLE: Chemical Biology-Based Tools to Uncover the Function of PARP16 in cancer


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Data Science;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Hepatotoxicity is a leading safety concern in the development of new chemicals. We will create virtual “Adverse Outcome Pathway” models that will directly evaluate the hepatotoxicity potentials of chemicals using massive public toxicity data. The primary deliverable of this project will be a publically-accessible, web-based search engine to evaluate new chemicals for risk of hepatotoxicity.

PI_NAMEs: ZHU, HAO  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;adverse outcome;Animal Experiments;Animal Model;Animal Testing;Antioxidants;Big Data;Biochemical;Biological;Biological Assay;Biological Markers;candidate validation;cell injury;Cellular Stress;Chemical Injury;chemical safety;Chemical Structure;Chemicals;Clinical;combat;Complement;Complex;computational toxicology;computer framework;Computer Models;Computer software;computerized tools;Computers;cost;Cryopreservation;Custom;Data;data mining;Data Pooling;Data Set;Data Sources;Databases;deep neural network;design;Development;developmental toxicity;Drug Costs;drug development;endoplasmic reticulum stress;Ensure;Environment;Environmental Pollutants;Evaluation;experimental study;Face;Generations;hepatocellular injury;Hepatocyte;Hepatotoxicity;Human;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Industrialization;Injury;interest;Internet;knowledgebase;large datasets;Libraries;Liver;liver injury;Luciferases;Machine Learning;Methodology;Methods;Mining;Modeling;next generation;novel;Nutraceutical;Online Systems;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Population;post-market;pre-clinical;predictive modeling;Process;Property;Proteomics;PubChem;Public Health;Quantitative Structure-Activity Relationship;reproductive toxicity;Research;research clinical testing;Research Personnel;Resources;Response Elements;Risk;Safety;safety assessment;safety testing;screening;search engine;Signal Transduction;Source;Statutes and Laws;System;Test Result;Testing;tool;Toxic effect;toxicant;Toxicology;transcriptomics;Translating;Validation;Vertebrates;virtual;web portal

PROJECT_TITLE: Mechanism-Driven Virtual Adverse Outcome Pathway Modeling for Hepatotoxicity

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HANOI

ORG_COUNTRY: VIETNAM

ORG_FIPS: VM

ORG_NAME: HANOI MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Even though young men who have sex with men (YMSM) in Vietnam are disproportionately affected by the HIV epidemic, HIV testing and pre-exposure prophylaxis (PrEP) uptake among this group are low. By proposing to adapt an mobile health (mHealth) intervention developed in the United States for YMSM in Vietnam and explore barriers to implementing the app, the proposed study will provide critical guidance for the implementation of mHealth interventions for HIV prevention, not only in Vietnam but also in other low-resource settings. This research holds great potential to improve HIV testing and PrEP use among YMSM and significantly contribute to the goal of ending the AIDS epidemic globally.

PI_NAMEs: NGUYEN, MINH XUAN BINH (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;Affect;AIDS prevention;Area;arm;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Clinic;community engagement;community organizations;condoms;Control Groups;cost;Data;design;Development;Diagnostic Reagent Kits;Effectiveness;effectiveness/implementation trial;Eligibility Determination;Ensure;Epidemic;evidence base;Evidence based intervention;experience;field study;Focus Groups;Goals;Health;health organization;HIV;HIV Infections;HIV risk;HIV/STD;Human immunodeficiency virus test;Hybrids;implementation strategy;improved;Incidence;Individual;innovation;Intervention;Interview;Location;low and middle-income countries;Maintenance;meetings;men who have sex with men;Methods;mHealth;mhealth interventions;Modeling;older men;Participant;Pilot Projects;Population;pre-exposure prophylaxis;Prevalence;prevention service;Privacy;Provider;Randomized;randomized controlled design;Randomized, Controlled Trials;Reporting;Research;Resource-limited setting;Resources;Risk;Risk Behaviors;scale up;Services;social cognitive theory;standard of care;Surveys;System;systematic review;Target Populations;Technology;technology intervention;Testing;Time;tool;Training;transmission process;treatment arm;United States;uptake;usability;Vietnam;Vietnamese;Work;young men who have sex with men

PROJECT_TITLE: Adapting an evidence-based intervention to improve HIV testing and PrEP uptake among young men who have sex with men in Vietnam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Depression;Heart Disease;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death worldwide, risk begins early in life, and as a result, policy organizations are recommending that optimal promotion of cardiovascular health begin during childhood. Prenatal maternal depressive symptoms predict offspring cardiovascular risk, though this association has not been demonstrated experimentally; as such, the proposed research will follow up a sample of offspring from pregnant mothers who participated in a randomized controlled trial to test whether reducing prenatal maternal depressive symptoms improves offspring cardiovascular health in early childhood. This research will determine whether an established, effective psychosocial intervention to reduce depression during pregnancy also reduces cardiovascular risk early in life in the next generation.

PI_NAMEs: DAVIS, ELYSIA POGGI (contact);DOOM, JENALEE RAE;HANKIN, BENJAMIN L

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;adverse birth outcomes;Age;American Heart Association;antepartum depression;Arterial Fatty Streak;arterial stiffness;associated symptom;Barker Hypothesis;Behavior;Birth;Blood Pressure;Body fat;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Child;Child Behavior;Child Mental Health;Childhood;Clinical Trials;Cognitive;Data;Deposition;depressive symptoms;Development;Diabetes Mellitus;Diet;dietary;early childhood;Eating;Eating Behavior;effective intervention;efficacious intervention;emotion regulation;Emotional;emotional functioning;endothelial dysfunction;Epidemiology;Epigenetic Process;ethnic diversity;Exposure to;Fatty acid glycerol esters;Feeding behaviors;Feeds;follow-up;Food;food quality;Gestational Age;Goals;Health;Health behavior;Health Promotion;Hypertension;Immune;Impairment;improved;Informal Social Control;insulin sensitivity;Intervention;intrauterine environment;Knowledge;Life;life span;longitudinal design;Longitudinal Studies;Low Birth Weight Infant;Low income;Maternal Behavior;maternal depression;Mediating;Mediator;Metabolic;Modeling;Mothers;Neurosecretory Systems;next generation;Nursery Schools;Obesity;obesity in children;obesogenic;offspring;Organizational Policy;Outcome;Participant;Pathway interactions;Physical activity;Physiological;Physiology;postnatal;preference;Pregnant Women;Premature Birth;prenatal;prenatal intervention;Prevalence;Prevention;protective factors;psychosocial;racial diversity;Randomized, Controlled Trials;rapid infant weight gain;Recommendation;reduce symptoms;Research;Risk;Risk Factors;Sampling;sedentary lifestyle;Signal Transduction;Sleep;Stress;symptomatic improvement;System;Testing;Time;trial design;waist circumference;Work

PROJECT_TITLE: Reducing maternal prenatal depression to improve child cardiovascular health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Genetics;Lung;Neurosciences;Pediatric

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The first breath of air for an infant is a crucial and celebrated event that requires careful coordination of many physiological systems including implementation of the neural circuitry that will continue to mediate respiratory rhythm throughout the entirety of life. Failure to properly execute this transition and sustain appropriate respiratory efforts during this vulnerable developmental period can leave the infant susceptible to developing life threatening conditions such as sudden infant death syndrome. Therefore, an understanding of the molecular signals and gene regulatory mechanisms that support respiratory efforts during this transitional time are necessary to identify interventions for potentially life-threatening respiratory disorders, and this application seeks new information on the role and gene regulation of the neuropeptide PACAP in stabilizing and protecting respiratory efforts in neonates.

PI_NAMEs: CLEMENTS, RACHEL  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Adult;Air;Amniotic Sac;Apnea;Birth;Blood gas;Brain Stem;Breathing;Carbon Dioxide;Cell Nucleus;Cells;central pattern generator;Chemoreceptors;Complex;conditional knockout;critical period;Custom;Detection;Development;Developmental Process;Event;Exposure to;Failure;Feedback;Frequencies;Gases;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;genome wide association study;Glutamates;GPR4 gene;Homeostasis;Hour;Hypercapnia;In Situ Hybridization;Incidence;Infant;Intervention;Knock-out;Knockout Mice;Laboratories;Lateral;Left;Life;Measurement;Mediating;Molecular;Mus;NBPhox protein;neonatal mice;neonatal period;neonatal respiration;neonate;neural circuit;neuromedin B;Neurons;Neuropeptides;neurotransmission;novel;Output;Phenotype;Physiological;pituitary adenylate cyclase activating polypeptide;Placenta;Population;postnatal;postnatal development;postnatal period;Predisposition;programs;Protons;Reflex action;Regulation;Research;Respiration;Respiration Disorders;respiratory;Respiratory physiology;response;Role;sensor;Signal Transduction;Stimulus;stressor;Sudden infant death syndrome;System;Testing;thermal stress;Time;transcriptome;transcriptomics;Up-Regulation;Variant;Whole Body Plethysmography;Work

PROJECT_TITLE: Regulation of PACAP expression and its role in protecting early neonatal respiration.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-J (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Certain neuropsychiatric disorders may be associated with synaptic dysfunction resulting from impairment of synaptic cell adhesion molecules (SAM). SAMs promote synapse physiology and prevent pruning by tethering the presynaptic and post synaptic membranes, but the molecular web of SAMs that contribute to proper synapse physiology are not fully explored. This project will investigate the role of a novel hypothesized SAM, complement C1q like 3 (C1QL3), in regulating excitatory synapses by forming a trans-synaptic adhesion complex in primary neuron cultures; investigation of C1QL3’s, and its binding partners’, roles in organizing synaptic nano- architecture will elucidate key mechanisms that regulate synaptic plasticity.

PI_NAMEs: CARO, KEAVEN DELWYN JACOB (contact)

PROJECT_TERMS: Adhesions;Affect;Affinity;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Binding;Binding Proteins;Biological Assay;Cell Adhesion Molecules;Cell surface;Cell-Cell Adhesion;Cells;Central Nervous System;Clinical;Complement 1q;Complex;Data;density;Development;Disease;Dissociation;Doctor of Medicine;Doctor of Philosophy;Embryo;Enzyme-Linked Immunosorbent Assay;Epitopes;Equilibrium;Excitatory Synapse;Functional disorder;Future;G-Protein-Coupled Receptors;Genes;Goals;Health;Human;Impairment;insight;Institution;Internet;Intervention;Investigation;kidney cell;knock-down;Knock-out;Link;Maintenance;Mediating;member;Mentors;Modeling;Molecular;Monitor;Mus;mutant;nanoarchitecture;nanomolar;neuronal pentraxin;Neurons;neuropsychiatric disorder;novel;novel therapeutics;overexpression;Patients;Peptide Hydrolases;pharmacologic;Physicians;Physiology;postsynaptic;Postsynaptic Membrane;presynaptic;presynaptic neurons;Presynaptic Terminals;prevent;programs;Property;protein protein interaction;protein purification;Proteins;Proteolytic Processing;Publications;Regulation;repaired;Research Training;Role;Scientist;skills;Structure;superresolution microscopy;Symptoms;Synapses;Synaptic Cleft;synaptic function;Synaptic plasticity;synaptogenesis;Testing;Therapeutic;Time;Virus;Western Blotting

PROJECT_TITLE: The Molecular Role of C1QL3 and its Binding Partners in Synaptic Regulation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Fatigue Syndrome (ME/CFS);Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Acute and chronic effects of viral diseases can lead to long-COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This annual workshop links leading international scientific investigators in a discussion of cutting-edge research developments on underlying inflammatory mechanisms related to viral infection, and its clinical implications. Special efforts will be made to recruit the participation of early career investigators and investigators from underrepresented minority groups.

PI_NAMEs: KURITZKES, DANIEL R. (contact);SPUDICH, SERENA S

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: 2019-nCoV;Acute;Aftercare;Anti-Inflammatory Agents;Anti-viral Agents;Autoimmune;Autoimmune Process;Autoimmunity;career;Chronic;Chronic Fatigue Syndrome;Clinical;Collaborations;Complex;Cytomegalovirus;Data;data sharing;Ebola;Educational workshop;Fostering;Future;Future Generations;Health;HIV;Human Herpesvirus 4;Immune;immune activation;immune reconstitution;Immune system;Inflammation;Inflammatory;Inflammatory Response;International;Knowledge;Link;Long COVID;Mediating;meetings;Minority Groups;Molecular;Multiple Sclerosis;neutralizing antibody;Participant;Pathology;Patients;Pharmaceutical Preparations;Prevalence;recruit;Research;research and development;Research Personnel;response;Severities;Societies;symposium;Syndrome;Therapeutic Intervention;therapeutic vaccine;Translating;Underrepresented Minority;Viral Encephalitis;Virus;Virus Diseases

PROJECT_TITLE: Viral Infection and Inflammation Workshop 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE Animals utilize complex multicellular nervous systems to sense their environment, but little is known about the sensory systems of unicellular eukaryotes and how these sensory transduction mechanisms laid the foundations for animal origins. As a novel model for sensory biology, we propose the study of choanoflagellates, the closest relatives of animals which display both unicellular and simple multicellular forms, both of which integrate environmental cues to find bacterial prey. We plan to build a mechanistic understanding of choano sensory biology by identifying receptors, signal transduction mechanisms and behavioral outputs, with particular interest in how these sensory systems evolve as choanos speciate and adapt to new environments, particularly through the evolution of simple multicellular forms.

PI_NAMEs: COYLE, MAXWELL CLARK (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Action Potentials;Advisory Committees;Alleles;Anemone;Animals;Behavior;Behavioral;behavioral response;Biochemical;Biochemistry;Bioinformatics;bioinformatics tool;Biology;cell behavior;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;Cellularity;Chemotaxis;Cloning;Collaborations;Communication;Complex;Cues;Data;Decision Making;desensitization;Ecology;electrical property;Electrophysiology (science);Engineering;Environment;Esthesia;Eukaryota;Event;Evolution;Family;Foundations;Gene Family;Gene Transfer Techniques;Genetic;Genetic Engineering;Genome;genome editing;Habitats;Homologous Gene;innovation;interest;Knock-out;Learning;Liquid substance;Measures;Mediating;Microfluidics;Microscopy;model organism;Modeling;Molecular;Nervous System;novel;Octopus;Organism;Output;Oxygen;patch clamp;pH gradient;pharmacologic;Physiological;Physiology;Preparation;Property;Protein Kinase;receptor;response;Second Messenger Systems;Sensory;sensory integration;sensory mechanism;Sensory Receptors;sensory stimulus;sensory system;Shark;Signal Transduction;skills;small molecule;Stimulus;Swimming;System;Testing;tool;transcriptome;voltage

PROJECT_TITLE: Exploiting unicellular animal relatives to understand the evolution of sensory systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative Maternal postpartum depression has significant consequences for the health and development of infants, and racial disparities in the incidence of postpartum depression may render Black infants at particular risk. Knowledge of the consequences of postpartum depression in Black families may help to inform family-based interventions targeting maternal postpartum depression and parent-infant relationships. The proposed project will contribute to the promotion of foundational regulatory capacities and lifelong health in Black infants.

PI_NAMEs: ARMAH, ANNABELLE  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Affect;Affective;Age;behavioral health;Biological;biological adaptation to stress;Birth;Black Populations;Black race;black women;Buffers;Caring;Child;Child Development;Collaborations;coping;Coping Skills;Data;depressive symptoms;Development;Discrimination;Emotions;experience;Exposure to;Family;Fellowship;follow-up;Funding;Generations;Gestational Age;Goals;Health;health determinants;high risk;Incidence;Infant;Infant Development;Informal Social Control;intergenerational;Intervention;Investigation;Knowledge;Link;Literature;longitudinal, prospective study;maternal depression;maternal wellbeing;Measures;Mental Depression;Mental Health;Mental Health Services;minority stress;Mothers;Outcome;Outcome Study;Parent-Child Relations;Parents;Patient Self-Report;perceived discrimination;perinatal period;Personal Satisfaction;Physiological;Physiology;Play;Population;Postpartum Depression;Postpartum Period;Process;prospective;protective factors;Psychophysiology;psychosocial;Psychosocial Stress;Public Health;racial discrimination;racial disparity;racial health disparity;Reporting;Research;resilience factor;Risk;Risk Factors;risk mitigation;Role;Sampling;self-reported depression;Shapes;social;social culture;Statistical Data Interpretation;success;Symptoms;System;Third Pregnancy Trimester;Training;training opportunity;transmission process;United States National Institutes of Health;White Women;Woman;Work

PROJECT_TITLE: Understanding the Intergenerational Transmission of Risk in Black Mother-Infant Dyads: Postpartum Depression, Physiological Synchrony, and Infant Regulatory Development


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Myosin is a molecular motor that uses the energy from ATP hydrolysis to drive the sliding of thick and thin filaments in cardiac muscle, which allows for the pumping of blood in the left ventricle to the systemic system. Mutations in human beta-cardiac myosin have been implicated as a putative genetic cause of left ventricular non-compaction, a rare but increasingly prevalent cause of cardiomyopathy characterized by spongiform endocardium. This proposal will investigate the impact of left ventricular non-compaction mutations on several aspects of human beta-cardiac myosin structure and function, including the regulatory mechanism, structural mechanism of force generation, and calcium-dependent ATPase mechanism.

PI_NAMEs: BODT, SKYLAR ML (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Actins;Affect;African ancestry;American Heart Association;analytical ultracentrifugation;arm;ATP Hydrolysis;ATP phosphohydrolase;beta-Myosin;Binding;Biological Assay;biophysical analysis;biophysical properties;Biophysics;Biosensor;blood pump;Calcium;Cardiac Myocytes;Cardiac Myosins;Cardiomyopathies;Clinical;comorbidity;Complex;Congenital Heart Defects;Congestive Heart Failure;CRISPR/Cas technology;Depressed mood;design;Development;Dilated Cardiomyopathy;dimer;Disease;Dissociation;early onset;Endocardium;Etiology;experimental study;falls;FDA approved;Fluorescence Resonance Energy Transfer;Functional disorder;Future;Generations;Genetic;Genotype;Goals;Head;Heart;Heart Diseases;Heart failure;Heritability;Heterogeneity;Heterozygote;Homozygote;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Impairment;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;inorganic phosphate;insight;Kinetics;Lead;Left;Left ventricular non-compaction;Left ventricular structure;Life;Light;Location;male;Measurement;Measures;Molecular;Molecular Conformation;Molecular Motors;monomer;Motility;Motor;Muscle;mutant;Mutate;Mutation;Myocardial;Myocardial dysfunction;Myocardium;Myofibrils;Myosin ATPase;novel;Pathogenesis;Pathogenicity;Pathway interactions;Performance;Pharmacologic Substance;Phenotype;Play;Point Mutation;Positioning Attribute;Power stroke;Preparation;Prevalence;Primary Myocardial Diseases;Property;protein purification;protein structure function;Proteins;Relaxation;Research;Role;Sarcomeres;Severities;Slide;small molecule therapeutics;stem;Structure;sudden cardiac death;Symptoms;System;Tail;targeted treatment;Techniques;Therapeutic;Thick Filament;Thin Filament;Tissues;Transducers;Tropomyosin;Variant;Ventricular;Ventricular Remodeling;Work

PROJECT_TITLE: Molecular Basis of Left Ventricular Non-Compaction Mutations in Cardiac Myosin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Dysfunction in any one of 13 different peroxisomal biogenesis proteins (known as peroxins) results in a family of diseases known as Zellweger spectrum disorders (ZSDs), where patients present with severe neurological symptoms, including developmental delay and seizures. The goal of this study is to understand the mechanisms by which peroxisomal dysfunction results in these severe neurological phenotypes by exploring the effects of knocking out the peroxin PEX11b, a key protein necessary for peroxisomal fission and one of the proteins mutated in ZSDs. I hypothesize that PEX11b deficiency affects peroxisomal metabolic functions, and consequently, cell fate decisions during early human neurodevelopment; successful completion of this study would provide critical insight into peroxisomal biology, peroxisomal metabolic contributions, and how peroxisomal dynamics are altered in ZSDs.

PI_NAMEs: BODNYA, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;Affect;automated analysis;Axon;Binding;Bioenergetics;Biogenesis;Biological Assay;Biology;Brain;brain tissue;Cell Fate Control;cell fixing;cell motility;cell type;Cells;Cellular Structures;Cerebral cortex;Cerebrum;Complement;CRISPR/Cas technology;Data;Defect;Developmental Delay Disorders;Disease;Down-Regulation;Dynamin;Enzymes;Event;Exhibits;Failure;Family;fatty acid metabolism;fatty acid oxidation;Functional disorder;Generations;genetic manipulation;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Human;human induced pluripotent stem cells;human model;Image;Impairment;Individual;insight;Knock-out;Laboratories;Length;Life Expectancy;Lighting;Link;lipidomics;Maintenance;Masks;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Membrane;Membrane Lipids;Metabolic;metabolic profile;Metabolism;metabolomics;Microscopy;Mitochondria;Mitosis;Modeling;Molecular;Morphology;mouse model;Mutate;Mutation;Myelin;nerve stem cell;neural;neurodevelopment;neurodevelopmental effect;neurogenesis;Neurologic;Neurologic Symptoms;Neurosphere;Organelles;Organoids;oxidation;Patients;peroxisome;Phenotype;Play;prevent;Process;Production;Proliferating;Prosencephalon;Proteins;recruit;Role;segregation;Seizures;self-renewal;stem cell fate;superresolution microscopy;Techniques;Testing;Therapeutic;Very Long Chain Fatty Acid;white matter

PROJECT_TITLE: Examining the Impact of Peroxisomal Fission on Cell Fate Decisions During Neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The effectiveness of immune checkpoint blockades (ICBs) in treating triple-negative breast cancer (TNBC) is hindered by poor immune response and low antigen presentation of the cancer cells. This project aims to address the knowledge gap by investigating the role of PIK3C2A in tumor antigen presentation and its impact on anti- tumor immunity within the tumor microenvironment. Identification of PIK3C2A as a key target for tumor antigen presentation is a critical step towards designing small molecule inhibitors to enhance the efficacy of ICBs in TNBC treatment.

PI_NAMEs: WANG, XIYU  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 4T1;Acceleration;Address;aggressive breast cancer;Algorithms;anti-PD-1;antigen binding;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;antitumor effect;Autoantigens;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer infiltrating T cells;cancer subtypes;CD8-Positive T-Lymphocytes;cell killing;cell mediated immune response;Cell membrane;Cell surface;cell type;Cells;Chromosomal Instability;Chromosomal Stability;Clinical;Clinical Research;combination cancer therapy;Combination immunotherapy;Combined Modality Therapy;Complex;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Development;druggable target;Effectiveness;Endocytic Vesicle;Endocytosis;Endocytosis Pathway;Enzyme-Linked Immunosorbent Assay;Epidermal Growth Factor Receptor;Estrogen Receptors;exhaust;experimental study;Foundations;Future;Gene Expression Profile;Generations;Goals;Human;I-antigen;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunocompetent;immunodeficiency;immunogenicity;Immunotherapeutic agent;Immunotherapy;implantation;In Vitro;in vivo;Inbred BALB C Mice;inhibitor;knock-down;Knowledge;Laboratories;Link;Major Histocompatibility Complex;Malignant Breast Neoplasm;Mediating;Metabolism;Methods;Molecular;mouse model;mRNA sequencing;Mus;Mutation;Neck;neoantigens;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;Ovum;Patients;Phosphatidylinositols;phosphoinositide-3,4-bisphosphate;Phosphotransferases;Physicians;prevent;Process;Progesterone Receptors;programmed cell death ligand 1;protein function;Protein Isoforms;receptor binding;Recycling;Research;Resolution;response;Role;Scaffolding Protein;Scientist;Shapes;small hairpin RNA;small molecule inhibitor;Solid Neoplasm;specific biomarkers;Surface;Surface Antigens;Survival Rate;Testing;Therapeutic;Therapeutic Agents;therapeutic development;Training;transcriptomic profiling;transcriptomics;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Up-Regulation

PROJECT_TITLE: PIK3C2A is a vulnerable immunotherapeutic target in triple-negative breast cancer combination therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Community re-entry following residential opioid use disorder (OUD) treatment is a characterized by high rates of return to use, overdose, and death, yet little is known about treatment utilization during this extremely high- risk transitional period. Characterizing treatment utilization during this vulnerable, time-sensitive window is an important next step in research. By describing treatment utilization (i.e., type, timing, and frequency), and identifying facilitators, barriers, and predictors to treatment utilization, this project will inform best practices for continuity of care and development of evidence-based tools that may delay and/or prevent return to opioid use.

PI_NAMEs: NEWBERGER, NOAM  (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Abstinence;Acceleration;Acute;Address;Adult;barrier to care;Behavior;Behavior assessment;Caring;Cessation of life;Characteristics;Clinical;Clinical Data;Communities;community reentry;Continuity of Patient Care;Data;Data Analyses;Data Analytics;Development;Discrimination;Ecological momentary assessment;evidence base;experience;Frequencies;Funding;Future;Harm Reduction;high risk;Housing;improved;Individual;innovation;Inpatients;Intervention;Knowledge;knowledge integration;Machine Learning;machine learning model;Mental Depression;Methods;Modeling;National Institute of Drug Abuse;Needle-Exchange Programs;open data;opioid use;opioid use disorder;Outcome;Overdose;overdose prevention;overdose risk;Parents;Pattern;Persons;Prediction of Response to Therapy;Predictive Factor;predictive modeling;prevent;preventive intervention;Process;programs;Public Health;Recovery Support;Research;research data dissemination;Residential Treatment;return to use;Risk;Risk Reduction;Science;skills;social structure;Strategic Planning;structural determinants;Symptoms;System;Target Populations;Techniques;Time;tool;Training;United States National Institutes of Health

PROJECT_TITLE: Treatment Utilization During Community Reentry of Opioid Use Disorder Inpatients


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: PROJECT NARRATIVE To become infectious, viruses with multi-segmented double-stranded RNA genomes need to identify and package the correct collection of RNA molecules, but how this process occurs is poorly understood. The studies proposed in this application will increase our understanding of selective RNA packaging mechanisms for reovirus, a segmented double-stranded RNA virus that is currently in clinical trials as a cancer therapy. These discoveries could aid in our future ability to engineer reoviruses that are more efficient in targeting cancer cells.

PI_NAMEs: FLORES, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 3' Untranslated Regions;Acylation;Automobile Driving;Benign;Biochemical;Biological Models;cancer cell;cancer therapy;Capsid;Cell Culture Techniques;Cell Differentiation process;Characteristics;Clinical Trials;Collection;Complex;Data;Defective Viruses;Double Stranded RNA Virus;Double-Stranded RNA;Effectiveness;Elements;Engineering;Future;Gene Modified;Generations;Genetic;Genetic Engineering;Genetic Recombination;Genetic Transcription;Genome;Genomic Segment;Goals;Helper Viruses;Hydroxyl Radical;improved;Knowledge;Malignant Neoplasms;Mammalian Orthoreovirus;Mediating;Modeling;Modification;Molecular Virology;nanopore;next generation;Oncolytic;Oncolytic viruses;Open Reading Frames;particle;Pathogenicity;Pattern;Plasmids;Polymerase;Population;Primer Extension;Process;Property;Publishing;Reovirus;Reporter Genes;Research;reverse genetics;RNA;RNA chemical synthesis;RNA Sequences;Serial Passage;Signal Transduction;stem;Structure;Testing;Therapeutic;Third Generation Sequencing;Translations;Vaccines;Viral;Viral Genome;Viral Packaging;viral RNA;Virus;Virus Assembly;Virus Replication

PROJECT_TITLE: Elucidating RNA determinants for reovirus packaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences;Nutrition

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Recent studies in C. elegans have shown TGF-β signaling from ASI sensory neurons and the unfolded protein response of the endoplasmic reticulum (UPRER) are essential to extend longevity of worms undergoing dietary restriction. However, the potential convergence of these evolutionarily conserved pathways in regulating dietary restriction has yet to be explored. This proposal will use established cellular and biochemical approaches in combination with genetic C. elegans models to interrogate how FICD/FIC-1, the evolutionarily conserved AMPylase which regulates the UPRER through BiP/HSP-3 modification and reduces pathogen- induced TGF-β signaling in ASI neurons, affects the pro-longevity benefits of dietary restriction—an essential prerequisite for our complete understanding and utilization of dietary restriction-related pathways for therapeutic potential.

PI_NAMEs: URBAN, NICHOLAS DAVID (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acute;Affect;Afferent Neurons;Aging;aging process;aging related disease;Biochemical;Body Size;Caenorhabditis elegans;Cause of Death;Cells;Communities;Critical Pathways;Data;dietary control;dietary requirement;dietary restriction;Down-Regulation;Endoplasmic Reticulum;Exhibits;experimental study;extend lifespan;Genetic;Goals;GRP78 gene;Health;Health Benefit;Human;human tissue;Impairment;improved;Individual;Intake;Intervention;Knock-out;knockout animal;Knowledge;Ligands;Link;Longevity;Malignant Neoplasms;Malnutrition;Mediating;Microscopy;Modeling;Modification;Molecular Chaperones;mutant;Neurodegenerative Disorders;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrient deprivation;Orthologous Gene;Outcome;pathogen;pathogen exposure;Pathway interactions;Physiological;Positioning Attribute;Protein Deficiency;Proteins;proteostasis;Protocols documentation;Publishing;Regulation;Reporter;response;Risk Factors;Role;Signal Pathway;Signal Transduction;Starvation;System;Testing;Therapeutic;tissue culture;Tissues;Transforming Growth Factor beta;United States;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Elucidating the roles of AMPylation and TGF-Beta signaling on eliciting the pro-health and longevity benefits of dietary restriction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: PROJECT NARRATIVE Child maltreatment and child exposure to adult intimate partner violence (IPV) often co-occur and are detrimental to the mental and physical health of children, yet few prevention programs address these intersecting forms of adversity using dual-generation approaches. The proposed study is a rigorous randomized controlled trial that uses a 2x2 factorial design to evaluate the potential synergistic benefits of delivering programming prenatally and during early childhood in order to support the mother-child relationship and ultimately prevent child maltreatment. If effective in preventing child maltreatment, these programs have the potential for high public health impact given that they are both cost-effective and readily scalable.

PI_NAMEs: HOWELL, KATHRYN H;MILLER-GRAFF, LAURA E. (contact);VALENTINO, KRISTIN

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 6 year old;active control;Address;Adult;Age;arm;Case Management;Child;Child Abuse and Neglect;child bearing;Child Health;Child Welfare;Control Groups;cost effective;Data;design;Development;early childhood;emerging adulthood;Emotions;empowerment;evidence base;experience;Exposure to;Family;follow-up;Generations;Grant;improved;Individual;infancy;innovation;Intervention;intimate partner violence;Mediating;Mental Health;Methods;Mother-Child Relations;Mothers;Outcome;Parent-Child Relations;Participant;Pathogenicity;physical conditioning;postnatal;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;Prevention;Prevention approach;Prevention program;Process;programs;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;recruit;revictimization;Risk Factors;Sampling;Site;Testing;three-arm trial;tool;Training;Training Programs;trial design;violence exposure;Vulnerable Populations;Woman;Work

PROJECT_TITLE: The unique and combined effects of prenatal and early childhood programming on child maltreatment: Examining mechanisms of change

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE An emerging body of research suggests that state-level restorative justice (RJ) policies may be linked to better mental health among survivors of adult intimate partner violence, however limited research has examined this association among adolescent girls who have experienced adolescent dating violence (ADV) and/or determined whether and how impacts differ by race/ethnicity. The proposed research uses a sequential explanatory mixed methods design, leveraging population-representative data and qualitative data collection with diverse ADV girl survivors, to assess the impact of state-level RJ policies and their implementation on depressive symptoms and suicidal ideation among ADV girl survivors over time. Research findings can inform efforts for an innovative, policy-based solution that can be easily scaled to reduce negative mental health sequelae of ADV and inform the enhancement of justice practices to promote mental health equity among ADV girl survivors.

PI_NAMEs: SHARPLESS, LAUREL ANN (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Accountability;Address;Adolescent;Adolescent Risk Behavior;Adoption;Adult;Adult women;Affect;Attenuated;Behavioral;Black race;boys;Buffers;career;Communication;Communities;Data;Data Collection;Databases;dating violence;depression prevention;depressive symptoms;design;Development;Discipline;Educational workshop;Environment;ethnic identity;Ethnic Origin;Ethnic Population;experience;Faculty;Feeling suicidal;Fellowship;Female Adolescents;Fostering;gender-based violence;girls;Goals;healing;health disparity;health equity;Health Policy;Health Priorities;Hispanic;improved;innovation;intervention delivery;Interview;intimate partner violence;Justice;Law Enforcement;Link;Mediation;member;Mental Depression;Mental Health;Mental Health Associations;Mental health promotion;Mentorship;Methods;Modification;Narration;National Institute of Mental Health;Not Hispanic or Latino;Outcome;Perception;perpetrators;Policies;Population;preference;Prevention strategy;preventive intervention;Process;protective effect;psychosocial;Public Health;Race;racial difference;racial identity;racial population;Rehabilitation therapy;repaired;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Role;scale up;Schools;Scientist;skills;Strategic Planning;Structure;Students;Suicide;Suicide prevention;Survivors;System;tenure track;Testing;Time;twelfth grade;Work;Writing;Youth

PROJECT_TITLE: Examining the Role of State-level Restorative Justice Policies and their Implementation in Mental Health Disparities among Adolescent Dating Violence Girl Survivors: A Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The goal of this project is to reveal the neural substrates of the decision of where to look next, a choice that encompasses sensory, cognitive, and motor components. Utilizing two novel urgent choice paradigms, the proposed work aims to delineate the contributions of specific cell types within an oculomotor cortical region to these distinct components with unprecedented temporal precision. The anticipated results will help to elucidate the mechanisms by which the brain makes this decision, and choices in general, which will contribute to our understanding of deficits in these functions associated with neurological disorders.

PI_NAMEs: KATTNER, EVAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Area;Attention;attentional modulation;base;Behavior;behavior measurement;Behavioral;Brain;cell type;Cognitive;cognitive function;Color;Conflict (Psychology);Cues;Data;Decision Making;design;directed attention;discrimination task;Dissociation;Event;experience;Eye Movements;Failure;frontal eye fields;Goals;Human;insight;Judgment;Laboratories;Location;Measures;Monkeys;Motion;Motor;Nervous System Disorder;neural;neural correlate;Neurons;nonhuman primate;novel;oculomotor;Perception;Performance;Phenotype;Play;Population;pressure;Process;Psychological reinforcement;Psychophysics;Reaction Time;Recording of previous events;Reporting;response;Rewards;Role;Saccades;Scanning;Sensory;Shapes;Signal Transduction;Stimulus;Structure;success;Time;time use;translational potential;Variant;Visual;visual motor;visual search;Work

PROJECT_TITLE: Neural Correlates of Spatial Attention Deployment and Perceptual Decision Making


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy

PHR: Narrative: Adolescents need accurate information about contraception to participate in shared decision-making and prevent teen pregnancy, but misleading information on the internet and social media can make this process complex. Clinicians are an important source of health information for patients, but often do not have the time or skillset to effectively engage in conversations about digital health information and misinformation. To help clinicians address digital information about contraception with adolescents, I will 1) collect and review content and communication strategies related to adolescent-focused digital information about contraception; 2) develop a stakeholder-adapted counseling framework and module for clinicians; and 3) test this framework and module with pediatricians.

PI_NAMEs: SMITH, CAMBRAY  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adherence;Adolescent;adolescent health;adolescent patient;Area;Attitude;Belief;Black race;Caring;Child Health;Clinical;clinical encounter;Coercion;Communication;Complex;Contraceptive Agents;Contraceptive methods;Counseling;Data;Decision Making;digital;digital health;Education;Effectiveness;empowerment;Environment;Equity;Ethics;Ethnic Origin;Exposure to;Face;Feasibility Studies;Feedback;Fertility;Future;Goals;Health;health belief;health empowerment;health equity promotion;health inequalities;Health Professional;Hispanic;Hour;improved;Indigenous;information framework;insight;Internet;Interview;Knowledge;Latinx;Learning;Legal;Light;literacy;Literature;Measures;media use;medical specialties;Methods;Minor;Misinformation;Modernization;National Institute of Child Health and Human Development;Parents;patient health information;patient oriented;Patients;pediatrician;Persons;Physicians;Policies;Population;Predisposition;pregnancy health;Pregnancy in Adolescence;prevent;Process;Proliferating;provider communication;Race;Reduce health disparities;Reporting;reproductive;Research;Role;Safety;Self Efficacy;sexual and reproductive health;shared decision making;side effect;skills;social health determinants;social media;socioeconomics;Source;stem;Strategic Planning;success;Surveys;Testing;Time;Training;Training Activity;transition to adulthood;Youth

PROJECT_TITLE: Helping clinicians address digital information about contraception with adolescents


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Treatment of pediatric cancer is exceedingly challenging due to the irregular and inconsistent drivers and the need to reduce off-target side effects of cancer treatments in still-developing children. Understanding the molecular mechanisms driving oncogenesis in pediatric cancer is vital for the development of more effective targeted therapeutics. The proposed study will investigate the structural basis for the homotypic interactions underlying Ewing sarcoma and the effects of those interactions on transcription and DNA repair.

PI_NAMEs: SOHN, ERICH  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Adolescent;Automobile Driving;Binding;Biochemical;Biological Assay;Biophysics;Bone Tissue;BRCA1 gene;Breast Cancer Prevention;C-terminal;cancer therapy;career;Cell Survival;Cells;Cellular biology;Characteristics;Child;Childhood;Childhood Cancer Treatment;childhood sarcoma;Chimeric Proteins;Chromatin;Chromatin Remodeling Factor;Chromosomal translocation;Data;Defect;Development;Disease;Dissociation;DNA Binding Domain;DNA Damage;DNA Repair;Ewings sarcoma;Family;Fli-1 protein;Fluorescence Polarization;Friend leukemia;Genetic Transcription;Goals;Homo;homologous recombination;homologous recombination deficiency;Impairment;Investigation;leukemia;Ligands;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;member;Microscopy;Molecular;molecular dynamics;Mutation;Mutation Analysis;N-terminal;Neoplastic Cell Transformation;Nuclear Magnetic Resonance;Nucleic Acid Binding;Oncogenic;Phenotype;Phosphorylation;Physical condensation;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;prevent;Process;Protein Deficiency;rare cancer;recruit;Regulation;repair function;Reporter;Research Personnel;RNA;RNA Polymerase II;RNA Recognition Motif;RNA-Binding Protein EWS;RNA-Binding Proteins;Role;Sarcoma;side effect;Site;Site-Directed Mutagenesis;soft tissue;Structure;t(11;22)(q24;q12);TAF15 gene;targeted treatment;Testing;Training;Transcriptional Regulation;tumor;tumorigenesis;Tyrosine;Work

PROJECT_TITLE: Structural and mechanistic investigation into EWS::FLI1 disruption of EWS function in transcription and DNA repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Venous malformation (VM) is a disease in which patients are affected by enlarged and abnormal veins that cause pain, disfigurement, and other severe complications. This study will use a novel mouse model of VM to investigate how TIE2, a protein that is often mutated in VM patients, and c-ABL, a protein that is involved in TIE2 signaling, play a role in formation of VM. In doing so, this project will increase our understanding of the mechanisms that drive VM formation and will investigate the therapeutic potential of targeting c-ABL to treat VM patients.

PI_NAMEs: BISCHOFF, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Affect;Area;Automobile Driving;Binding Proteins;Biological Assay;Blood Vessels;Cardiovascular system;cell motility;Cell Proliferation;Co-Immunoprecipitations;Cre driver;Data;Defect;Development;Disease;Endothelial Cells;Endothelium;FRAP1 gene;gain of function;Genetic;Goals;Hemorrhage;Hyperactivity;In complete remission;In Vitro;in vivo;in vivo Model;inducible Cre;Investigation;Lesion;Ligands;Ligation;Location;loss of function;Measures;Mediating;Methods;Modality;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;neonatal mice;new therapeutic target;novel;Pain;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiological;PI3K/AKT;preclinical study;Preclinical Testing;Protein Tyrosine Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Research;Rest;Role;Signal Transduction;Tamoxifen;targeted treatment;TEK gene;Testing;Therapeutic;three-dimensional modeling;Thrombosis;TIE-2 Receptor;Transgenic Mice;Transgenic Organisms;translational impact;Tube;Veins;Venous Malformation;Work;Xenograft procedure

PROJECT_TITLE: The Role of c-ABL in Mediating TIE2 Signaling and Formation of Venous Malformation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative: The proposed R36 will use a mixed methods study design to characterize the mental health and basic needs of Puerto Rican crisis migrant families who experienced cascading disasters, beginning with Hurricane María in 2017. Leveraging longitudinal survey data and person-centered qualitative data, the aims are designed to identify areas of support needed by crisis migrant families over time, yielding critical information to reduce mental health disparities. The long-term goal of this research is to inform the development of timely and culturally relevant policy priorities to address the needs of a growing number of crisis migrant families. Given the expected rise in climate-related migration, this work is both relevant and timely.

PI_NAMEs: DIAZ, YARELIZ  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;anxiety symptoms;Area;Caregivers;Child;Child Mental Health;Classification;Climate;climate change;cohesion;Communities;Data;data centers;Data Sources;Decision Making;depressive symptoms;design;Development;Dimensions;Disasters;Disparity;Earthquakes;Evidence based intervention;experience;Exposure to;Family;Family dynamics;Florida;food insecurity;Friends;Future;Goals;Growth;Health;health disparity;Healthcare;Housing;Hurricane;improved;Individual;Infrastructure;innovation;instrument;Intervention;Interview;Investments;Island;Knowledge;Language;Letters;Life;Literature;Lived experience;Longitudinal Surveys;Mental Health;Methodology;Methods;Migrant;migration;Modeling;National Institute of Mental Health;Natural Disasters;Neighborhoods;Outcome;Parents;Perception;person centered;Personal Satisfaction;Policies;Population;Positioning Attribute;post-traumatic stress;Prevention;Preventive;protective factors;Public Health;Puerto Rican;Puerto Rico;Recording of previous events;Recovery;Reporting;Research;Research Design;Research Priority;Resources;Respondent;response;Risk;Risk Factors;Role;Safety;Sampling;School-Age Population;Shapes;Spanish;stressor;Structure;Subgroup;Surveys;System;Time;Trust;Unemployment;Vulnerable Populations;Work

PROJECT_TITLE: The mental health of crisis migrant families: A longitudinal, mixed-methods study of Puerto Rican child-parent migrants in the post-Hurricane María years

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Pancreatic cancer is a deadly disease with very limited treatment options. Suppression of immune responses is a hallmark of therapeutic resistance in this disease, inducing CD8 T cell dysfunction termed “exhaustion”. This proposal will interrogate the cellular and molecular mechanisms that induce T cell dysfunction in pancreatic cancer and introduce a novel strategy of immunotherapy using a small RNA molecule, microRNA-29a.

PI_NAMEs: RAFIE, CHRISTINE ISABELLE (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Adoptive Transfer;advanced disease;anti-tumor immune response;Antigens;Antitumor Response;Cancer Biology;cancer cell;Cancer Etiology;cancer type;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Lineage;Cells;Cessation of life;Characteristics;Chronic;chronic infection;Complex;cytokine;cytotoxicity;Data;data dissemination;Discipline;Disease;driver mutation;Ectopic Expression;Engineering;Epigenetic Process;exhaust;exhaustion;Exposure to;Flow Cytometry;Functional disorder;Genetic Transcription;Goals;Human;IL7R gene;Immune;immune checkpoint blockade;Immune response;Immunologic Memory;Immunology;immunomodulatory therapies;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Inflammatory;Intervention;KPC model;KRAS2 gene;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Melanoma;Memory;Metastatic/Recurrent;MicroRNAs;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoantigens;novel;novel strategies;Operative Surgical Procedures;overexpression;Ovum;palliative chemotherapy;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Phase;Phenotype;Pre-Clinical Model;prevent;progenitor;programmed cell death protein 1;Proliferating;recruit;Resistance;response;restraint;Role;Signal Pathway;Signal Transduction;skills;Small RNA;Stimulus;Stromal Cells;success;Surface;Survival Rate;synergism;T cell differentiation;T cell response;T memory cell;T-Lymphocyte;Testing;Therapeutic;therapy resistant;TNF gene;TP53 gene;Training;Translational Research;tumor;tumor microenvironment;Tumor Necrosis Factor Receptor;Tumor Volume;tumor-immune system interactions;United States;Work;Writing

PROJECT_TITLE: A novel immunotherapy for pancreatic cancer using micro-RNA-29a

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Each year millions of Americans are impacted by digestive and metabolic disorders that limit and disrupt their daily lives. The BMP molecular signaling pathway is required for normal gut functions like absorption of nutrients and suppression of cancer, yet the molecular details of how the BMP signals control the function of cells lining the gut remain unclear. My proposal creates novel mouse models to understand the genetic mechanisms driving and maintaining healthy intestinal function to uncover causes of and develop targeted treatments for intestinal diseases.

PI_NAMEs: LOGERFO, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: American;antagonist;Automobile Driving;Binding;Binding Sites;Bioinformatics;Biological Assay;Biology;BMPR1A gene;Body Weight decreased;bone loss;bone morphogenetic protein receptor type I;Bone Morphogenetic Proteins;career;Cell Compartmentation;Cell Differentiation process;Cell Line;Cell Physiology;Cell Therapy;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;cofactor;Collaborations;Complex;Data;Data Analyses;Development;Digestive System Disorders;Disease;Drug Screening;Enterocytes;epigenomic profiling;epigenomics;Epithelium;Equilibrium;Expression Profiling;Functional disorder;Gastrointestinal Diseases;Genes;Genetic;Genetic Models;Genetic Transcription;Goals;Health;Histologic;Histology;Homeostasis;Immunoprecipitation;improved;Individual;Infection;intestinal crypt;Intestinal Diseases;intestinal epithelium;intestinal villi;Intestines;Knock-out;Knowledge;MADH4 gene;Maintenance;Malabsorption Syndromes;Malignant Neoplasms;Mass Spectrum Analysis;Measurable;Mediating;Mediator;Mentorship;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;Modeling;Molecular;Molecular Genetics;Molecular Profiling;mouse genetics;mouse model;Mus;Natural regeneration;novel;nutrient absorption;Obesity;Organoids;Pathway interactions;Pattern;Phenotype;Physiology;Proliferating;Protein Family;Proteins;receptor;Regenerative Medicine;Research;Research Project Grants;response;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;skills;Smad Proteins;Small Intestines;Sorting;stem;stem cell division;stem cell expansion;stem cells;Structure;System;Techniques;Technology;Testing;Therapeutic;therapeutic development;Tissues;Training;training opportunity;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transplantation;Villous;Villus;Work;Writing

PROJECT_TITLE: Mechanisms of BMP signaling driving tissue pattern in the intestine

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: NARRATIVE This proposal will develop computer vision tools to augment a motile, cilia-powered, lung organoid platform, combining tissue engineering with computational analysis to present a complete bioengineering platform that accurately captures organoid motility and underlying cilia (dys)function. The goal of the current proposal is to utilize this platform to recapitulate the effects of pollution particulates on the lung epithelium, paving the way for personalized assessment of respiratory injury.

PI_NAMEs: BHATTARAM, DHRUV  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;airway obstruction;algorithm training;Algorithms;Apical;Asthma;Automation;Behavior;Biomedical Engineering;Biotechnology;Bronchiectasis;Cause of Death;Cells;Chemicals;Chronic Obstructive Pulmonary Disease;Cilia;ciliopathy;cilium motility;Clinical Management;combustion product;computational pipelines;Computer Analysis;Computer Vision Systems;computerized tools;Consumption;Coupled;Data;Data Sources;Defect;density;Detection;Diagnosis;Diameter;Dimensions;Disease;Dose;Electron Microscopy;Engineering;Environment;Environmental Pollution;Epithelium;Equipment;Escalator;Excision;Exhibits;experimental study;Exposure to;feature extraction;Frequencies;Functional disorder;Goals;Health;high dimensionality;high throughput analysis;Human;Impairment;improved;In Vitro;in vivo;injured airway;innovation;Investigation;Locomotion;Lung;machine learning algorithm;Methods;mimicry;miniaturize;Modeling;Molecular Conformation;mortality;Motility;Movement;Mucociliary Clearance;nano;nanoscale;non-invasive system;novel;Organoids;Particulate;Particulate Matter;Pathologic;Pathology;Patients;personalized management;personalized therapeutic;pharmacologic;Phenotype;Physiological;pollutant;pollutant interaction;Pollution;Population;prevent;Procedures;Reproducibility;Research;Resolution;Respiration Disorders;respiratory;Respiratory Disease;respiratory health;Respiratory System;response;response to injury;Risk Factors;scale up;Series;Shapes;Site;Smoking;spatiotemporal;Specific qualifier value;Speed;stem cells;Structure of parenchyma of lung;success;Surface;System;technological innovation;Testing;therapeutic development;Time;Tissue Engineering;tissue-level behavior;Tissues;tool;transcriptomics;Translating;Videotape

PROJECT_TITLE: Expedited Assessment of Environment-induced Respiratory Ciliopathies Leveraging Motile Apical-out Airway Organoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis, otherwise known as ALS or Lou Gehrig's disease, is a neurodegenerative disease leading to progressive paralysis and death that has few viable treatment options. We now know that immune cells, particularly neutrophils, play an important role in ALS, but the manner in which neutrophils contribute to disease progression is currently unclear. This proposal will identify types of neutrophils that are dysregulated in ALS, the mechanisms driving neutrophil activity in ALS, and the way these groups and mechanisms contribute to ALS progression, ultimately leading to new treatment options.

PI_NAMEs: BAIRD, LILLIA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acceleration;aged;ALS pathology;ALS patients;Alzheimer's disease patient;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Automobile Driving;axonal degeneration;Biological Assay;Biometry;Blood;Cell Physiology;cell type;Cells;Central Nervous System;Cessation of life;Clinical;comparison control;Critical Pathways;cytokine;cytotoxicity;Data;Development;Disease;disease model;Disease Progression;effective therapy;Experimental Autoimmune Encephalomyelitis;extracellular;familial amyotrophic lateral sclerosis;first responder;Flow Cytometry;functional status;Future;Genes;Goals;Hemorrhage;Heterogeneity;Immune;Immune response;Immune system;Immunophenotyping;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammatory;Magnetism;Measures;Mediating;migration;Molecular;Motor;motor neuron degeneration;Motor Neurons;mouse model;Multiple Sclerosis;Muscular Atrophy;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Injury;Neurons;neutrophil;Neutrophil Activation;Neutrophil Infiltration;new therapeutic target;novel marker;Onset of illness;Paralysed;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;peripheral blood;Plasma;Play;Population;predictive modeling;Production;Proteins;Protocols documentation;Publishing;Reactive Oxygen Species;recruit;repaired;Respiratory Failure;Respiratory physiology;response;Role;Sampling;Senile Plaques;Severity of illness;single-cell RNA sequencing;Speed;Spinal Cord;sporadic amyotrophic lateral sclerosis;Surface;TDP-43 aggregation;Testing;therapeutic development;therapeutic target;Tissues;trafficking

PROJECT_TITLE: The Role of Neutrophil Heterogeneity and Molecular Mechanisms in Driving ALS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]