ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Tyrosine kinase driven Non-small-cell lung cancers (NSCLC) develop resistance to tyrosine kinase inhibitors. Waiting for resistance, reverse engineering its molecular origins, and then responding to that resistance with new drugs is a slow, costly, and ultimately losing battle. This grant will propel the model driven forward engineering design of “dual-switch selection drives” in NSCLC that re-program tumor cells to work with existing therapies to combat drug resistance—regardless of molecular origin.

PI_NAMEs: PRITCHARD, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;arms race;Biological;Biophysics;Bystander Effect;Cancer Biology;cancer cell;Cancer cell line;Cancer Patient;cell killing;Cell Therapy;Cells;Chemicals;Clinical;Collaborations;combat;Combined Modality Therapy;Compensation;cost;Coupled;Cues;Data;design;Diffusion;Dimerization;Directed Molecular Evolution;drug development;drug discovery;Drug resistance;dual switch selection gene drive;effective therapy;efficacy evaluation;Endothelial Cells;Engineering;engineering design;Environment;Epidermal Growth Factor Receptor;Evolution;Exhibits;experimental study;Extracellular Matrix;Failure;Fibroblasts;fighting;fitness;gene drive system;Gene Library;Genes;Goals;Grant;Heterogeneity;Human;Immune;improved;In Situ;inhibitor;insight;Investigation;kinase inhibitor;Lead;Learning;Left;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;Mathematics;Measurement;Measures;mimetics;Modeling;Mole the mammal;Molecular;mutant;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel therapeutics;Oncogenes;Oncologist;Organoids;Patients;Performance;Pharmaceutical Preparations;pharmacologic;prevent;Process;Prodrugs;programs;Protein Tyrosine Kinase;prototype;Reproducibility;Resistance;Resistance development;resistance mechanism;resistance mutation;Resolution;response;Reverse engineering;Risk;ROS1 gene;Safety;simulation;small molecule;standard of care;suicide gene;Suicide Gene Therapy;SWI1;Switch Genes;synthetic biology;systemic toxicity;Tacrolimus Binding Protein 1A;Techniques;Technology;Testing;Therapeutic;Toxicity Tests;Toxin;treatment response;tumor;tumor microenvironment;Tyrosine Kinase Inhibitor;Validation;Variant;Work

PROJECT_TITLE: Personalization and Failure Testing of Dual Switch Gene Drives in Lung Cancer


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) is designed to train the next generation of biomedical scientists and physician-scientists with the application of innovative techniques/tools and approaches to address emerging public health concerns related to respiratory disease.

PI_NAMEs: GAGGAR, AMIT  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ANCHORAGE

ORG_NAME: SOUTHCENTRAL FOUNDATION

ORG_STATE: AK

PI_NAMEs: STILLWATER, BARBARA JANOAH (contact)

PROJECT_TERMS: Address;Administrator;Adoption;Adult;Age;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;Appointment;Area;Award;Belief;Blood Glucose;Blood Tests;care systems;Characteristics;Clinic;Clinical Research;Code;cohort;Communities;Complex;Complications of Diabetes Mellitus;Comprehensive Health Care;Consolidated Framework for Implementation Research;cultural competence;Data;Dental;Dental Care;Dental Clinics;design;Development;diabetes control;Diabetes Mellitus;diabetes risk;Diagnosis;disparities in morbidity;Dissemination and Implementation;dissemination science;Early Intervention;early screening;Enrollment;Evaluation;evidence base;experience;Fasting;Feedback;follow-up;Foundations;Glycosylated Hemoglobin;Grant;Health;health care service;health care settings;health data;Health Educators;health organization;Health system;Healthcare Systems;Home;Human Resources;Hygiene;implementation framework;implementation outcomes;implementation research;implementation science;improved;Incidence;Individual;Institution;Intervention;Interview;Life Style;Maintenance;Medical;Medical center;Methods;Modeling;Monitor;multidisciplinary;multiple chronic conditions;Native American Research Center for Health;novel;Patient Outcomes Assessments;Patients;Perception;Periodontal Diseases;Persons;Phase;point of care;Populations at Risk;pragmatic trial;Prevalence;prevent;Prevention;Preventive service;Primary Care;primary care clinic;primary care provider;primary care services;Process;Protocols documentation;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;referral services;Research;Research Personnel;Risk;Risk Factors;Rural;Sampling;screening;screening and brief intervention;screening services;service delivery;Services;Site;Specialist;Surveys;System;Testing;tool;tribal health;tribal healthcare;virtual;Visit;Walking;Work

PROJECT_TITLE: Implementing a Diabetes Screening and Referral Service Developed for Dental Clinics Within an Urban Alaska Native Health Care Setting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE HPV vaccination among adolescents is suboptimal, and parental delays and refusals are common. Addressing the unique vaccine hesitancy concerns and information needs of underserved families is critical to increase vaccination. This study will engage multiple stakeholders to develop and pilot a tailored intervention to address HPV vaccine hesitancy among Black families to increase vaccine confidence, vaccination, and ultimately help reduce HPV-related cancer disparities.

PI_NAMEs: KOHLER, RACQUEL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Adolescent;Affect;aged;arm;Attitude;Awareness;behavior change;Behavioral;Behavioral Research;Behavioral Sciences;Belief;Black Populations;Black race;black women;cancer health disparity;Cancer Prevention Intervention;cancer type;career;career development;Catchment Area;Clinic;Communication;Communities;community engaged approach;community engaged intervention;community engaged research;Complex;Data;design;Development Plans;Disparity;Dose;Education;effective intervention;Eligibility Determination;Enrollment;Environment;Equity;Ethnic Population;experience;Family;Focus Groups;follow-up;Funding;Funding Opportunities;Goals;health equity;Health Services Research;High Prevalence;high risk;Hispanic Populations;HPV screening;HPV vaccine hesitancy;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation barriers;implementation intervention;improved;Individual;informant;insight;Intervention;intervention mapping;Intervention Trial;Interview;Knowledge;Link;Literature;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Medical;Methods;Motivation;multi-site trial;New Jersey;Parents;Patients;perceived discrimination;pilot test;post intervention;prevent;Process;programs;prototype;Provider;racial discrimination;racial disparity;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Resources;Risk;safety net;screening;Self Efficacy;Shapes;skills;social;sociocultural determinant;Source;Southern Africa;Surveys;System;systematic review;tailored messaging;tailored text messaging;Testing;Text Messaging;text messaging intervention;timeline;Training;Transition Career Development Award (K22);Trust;underserved community;United States;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;vaccine safety;Vaccines;Woman;Work

PROJECT_TITLE: Addressing HPV vaccination disparities through tailored messaging for hesitant families


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: MICHLIG, GEORGIA J (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Agonist;Alaska;Alaska Native;Alaska Native population;Alaskan;American Indian Population;American Indians;arm;attributable mortality;Biological Markers;Bupropion;Caring;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;clinical practice;Communities;community based participatory research;community engagement;Consolidated Framework for Implementation Research;cost;Data;design;Dissemination and Implementation;Dopamine Uptake Inhibitors;Environment;Ethnic Population;Familiarity;Foundations;Genetic Research;Goals;Health;health disparity;health organization;Health system;Healthcare Systems;Heart Diseases;implementation facilitation;implementation framework;implementation intervention;implementation research;improved;Intervention;intervention refinement;Knowledge;Learning;Literature;Malignant neoplasm of lung;member;Metabolic;Metabolic Marker;Metabolism;Methods;Modeling;Nicotine;nicotine replacement;nicotine use;Nicotinic Receptors;Norepinephrine;Nurses;Observational Study;Participant;Patient Preferences;Patients;personalized approach;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacy facility;Physicians;pilot trial;pragmatic trial;Protocols documentation;Provider;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Project Grants;response;Selection for Treatments;Services;side effect;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Solid;Specialist;Stroke;success;Testing;Therapeutic;Tobacco;tobacco cessation intervention;Tobacco Use Cessation;treatment optimization;tribal health;tribal healthcare;varenicline;Work

PROJECT_TITLE: Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Owing to the significant clinical and societal burden of pediatric PNES and the limited remission rates of current adult treatment approaches, new strategies are needed for addressing pediatric PNES that utilize novel treatment targets. This study will evaluate a treatment for a common and serious pediatric health condition for which there are no established therapies and assess important targets mediating that effect.

PI_NAMEs: FOBIAN, AARON D (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TITLE: Retraining and Control Therapy (ReACT): Sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric psychogenic non-epileptic seizures (PNES)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE:  Ribonucleotides are being constantly incorporated into the genome by eukaryotic DNA polymerases. This project will investigate the processing of these genomic ribonucleotides by topoisomerase 1 (Top1) and the possible ramifications of this Top1 activity for transcription by introducing a novel mechanism for DNA supercoil relaxation by Top1. Our proposal will also provide insight into the mechanism of PARP1 regulation of genomic ribonucleotide excision by Top1, which will help us understand the way human cells respond to the lesions that arise from Top1 cleavage of genomic ribonucleotides.

PI_NAMEs: SARRAIN, EDWARD JAMES (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: adduct;Affect;Binding;Biochemical;Biological;BRCA1 gene;BRCA2 gene;cancer therapy;Cells;Chromosome Mapping;Complex;Coupled;Data;Deoxyribonucleotides;DNA;DNA Adducts;DNA Ligases;DNA Repair;DNA Structure;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Enzymes;Eukaryota;Excision;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Genomics;Human;In Vitro;inorganic phosphate;insight;Investigation;Laboratories;lead phosphate;Lesion;Ligation;Link;Mediating;Modeling;Molecular;Monitor;mRNA Expression;mutant;Nature;novel;nuclease;Pathway interactions;Periodicity;Phenotype;Physiological;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;preservation;prevent;Proteins;reconstitution;recruit;Regimen;Regulation;Relaxation;repaired;Research;Ribonucleases;Ribonucleotides;RNA;Role;Single-Stranded DNA;Site;Specificity;Stress;Structure;Superhelical DNA;Testing;Therapeutic;therapeutic target;Topoisomerase;Transcriptional Regulation;transcriptome sequencing;tumor;Work;Yeasts

PROJECT_TITLE: Topoisomerase 1-catalyzed genomic ribonucleotide excision, its regulation, and its implication in transcription.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Dietary Supplements;Digestive Diseases;Liver Disease;Natural Products

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Liver injury due to medication or herbal and dietary supplement use is an important medical, scientific, and public health problem in the US. Drug-induced liver injury (DILI) is the most common reason for non-approval, withdrawal, and clinical monitoring by the FDA. Understanding the dynamics of this medical problem and determining its clinical and genetic determinants will ultimately allow safer medications to be prescribed to patient populations and safer supplement on the market.

PI_NAMEs: BARNHART, HUIMAN X (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Adverse event;Ancillary Study;Area;Biochemical;Biological;biomarker discovery;Clinical;clinical center;Clinical Research;Communication Tools;Coupled;Data;Data Coordinating Center;data management;Data Management Resources;Data Set;design;Diabetes Mellitus;Diagnosis;dietary supplements;drug induced liver injury;Drug Prescriptions;Eligibility Determination;Ensure;experience;food surveillance;Future;genetic analysis;Genetic Determinism;Genetic Fingerprintings;Grant;Hepatotoxicity;Herbal supplement;high risk;Histologic;Incidence;Kidney Diseases;Knowledge;Liver diseases;liver injury;Logistics;Manuals;Marketing;Medical;meetings;Methods;Mining;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Products;Non-Prescription Drugs;novel;novel therapeutics;operation;participant enrollment;Pathogenesis;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;pharmacovigilance;predictive marker;Prevention;Procedures;Process;Productivity;Public Health;quality assurance;Reaction;recruit;Research;Research Infrastructure;Research Institute;response;Role;Statistical Methods;support network;United States;United States Food and Drug Administration;United States National Institutes of Health;web site;Withdrawal

PROJECT_TITLE: Drug Induced Liver Injury Network Data Coordinating Center


ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of the WU-PE-CGS is to build a rigorous, scientific evidence base for approaches direct engagement of cancer patients and post-treatment cancer survivors from rural and underserved populations as participants in cancer research. Our Center will provide a significant return on the scientific investment, resulting in innovations to advance participant engagement, outreach, and communication in genomic characterization studies.

PI_NAMEs: COLDITZ, GRAHAM A. (contact);DING, LI ;DRAKE, BETTINA F.

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Acceleration;Address;Advocacy;Aftercare;Age;anti-cancer research;cancer genomics;cancer health disparity;Cancer Patient;Cancer Survivor;Capital;career;Characteristics;Cholangiocarcinoma;CLIA certified;Colorectal Cancer;Communication;Communities;Complex;Creativeness;Development;Disadvantaged;Discipline;Disparity;Ensure;Environment;Evaluation;evidence base;Family;follow-up;Fostering;genome sequencing;Genomics;Goals;Health Benefit;Health system;improved;innovation;interdisciplinary collaboration;Investments;Knowledge;Leadership;Malignant Neoplasms;member;Methodology;Multiple Myeloma;outreach;Participant;Patient advocacy;patient engagement;patient oriented;patient population;Patients;Persons;Population;Positioning Attribute;Provider;rare cancer;recruit;Research;Research Personnel;Resources;Rural Population;Science;success;synergism;Technology;Testing;tumor;Underserved Population;understudied cancer;Universities;Vision;Washington

PROJECT_TITLE: Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PI_NAMEs: COLDITZ, GRAHAM A. (contact)

PROJECT_TERMS: Accountability;Advocate;Cancer Control;Cancer Control Research;cancer genomics;cancer health disparity;career;Cholangiocarcinoma;Clinical;Collaborations;Colorectal Cancer;Communication;Communities;Creativeness;Discipline;Effectiveness;Elements;Environment;Evaluation;Feedback;fighting;Fostering;Foundations;Funding;Future;genome sequencing;Genomics;Goals;Guidelines;Individual;Infrastructure;innovation;Knowledge;Leadership;Logic;Logistics;Maintenance;Malignant Neoplasms;meetings;member;Minority;Mission;Modeling;Monitor;Multiple Myeloma;operation;outreach;patient advocacy group;patient engagement;Patients;Population;Positioning Attribute;Process;Productivity;programs;Public Health;rare cancer;Recording of previous events;Records;Research;Research Personnel;response;Scholarship;Science;Scientific Evaluation;Scientist;Series;Structure;synergism;Time;timeline;Training;Translating;understudied cancer;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Our R25 program seeks to prepare physicians for independent and competitive research by developing researchers who can combine the clinical expertise obtained during residency with a well developed and focused investigative research program. The CHB/BIDMC residency program combines both adult and child neurology within an environment that has great breadth and depth in basic and clinical neuroscience. Mentors chosen for the R25 include leading NIH funded basic cellular and molecular neuroscientists, as well as successful physician scientists actively engaged in clinical and basic neuroscience and experienced in, and eager to train physician scientists.

PI_NAMEs: LIPTON, JONATHAN OREN (contact);SAPER, CLIFFORD B;VANDERHORST, VERONIQUE

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Adult;Anesthesia procedures;Area;Award;Basic Science;Boston;Brain;career;Cellular biology;Clinical;Clinical Research;Data;Department chair;design;Development;Diagnosis;Disease;Education Projects;education research;Educational process of instructing;effectiveness evaluation;Environment;experience;Faculty;Faculty Recruitment;Fellowship;Funding;Future;Genetic;Goals;Hospitals;Human;improved;Individual;insight;Israel;K-Series Research Career Programs;Laboratories;Learning;Medical center;medical schools;Medicine;Mentors;Molecular;Monitor;Nervous System Disorder;Neurobiology;Neurology;Neurosciences;Neurosciences Research;neurosurgery;novel therapeutics;Ophthalmology;Participant;Pathology;Pediatric Hospitals;Pediatric Neurology;Physicians;programs;Psychiatry;Publications;Radiology Specialty;Recording of previous events;recruit;Research;Research Personnel;Residencies;Resources;responsible research conduct;Science;Scientist;skills;Training;Training Programs;translational neuroscience;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Rare Diseases

PI_NAMEs: FIELDS, RYAN C (contact)

PROJECT_TERMS: Address;Adherence;Advanced Malignant Neoplasm;African American population;Age;Archives;Area;Biopsy;cancer care;cancer genomics;cancer health disparity;cancer type;Cholangiocarcinoma;Clinical;Clinical Trials Database;Colorectal Cancer;Communication;Consent;Data;Databases;design;Enrollment;Ensure;Evaluation;Excision;experience;fighting;Foundations;Future;Genome;Genomics;Goals;improved;individual patient;Informatics;innovation;Institution;interest;Investigation;Knowledge;Malignant Neoplasms;Metadata;Methodology;Methods;Minority;Minority Groups;Mission;Multiple Myeloma;novel;Participant;participant enrollment;participant retention;Pathologist;patient advocacy group;patient engagement;Patients;Physicians;Process;programs;prospective;Prospective Studies;Protocols documentation;Recommendation;recruit;Reporting;Research;Research Personnel;Sampling;Specimen;success;Techniques;Therapeutic;Time;tumor;Underserved Population;understudied cancer;Universities;Update;Vision;Washington;Work

PROJECT_TITLE: Participant Engagement Unit


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Disease;Pancreatic Cancer;Rare Diseases

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) Patients with pancreatic neuroendocrine tumors (pNETs) often have few symptoms before tumors have metastasized, hence most patients are diagnosed with late-stage disease for which there are few effective therapies. The incidence of pNETs increases yearly, but the development of newer and more effective therapies is still limited by our understanding of the biology of pNET tumorigenesis and progression. Modulation of the Notch2 signaling pathway is a promising approach for treating pNETs, and further characterization of the role of the Notch2 pathway in pNETs may deepen our understanding of NETs while facilitating the development of novel therapies.

PI_NAMEs: HERRING, BRENDON ROBERT (contact)

PROJECT_TERMS: Affect;Alabama;Amino Acids;Automobile Driving;Beds;Biology;Cancerous;career;Cell Differentiation process;cell growth;cell motility;Cell Nucleus;Cell Proliferation;Cells;Chromogranin A;Clinical;clinically relevant;Complex;CRISPR/Cas technology;curative treatments;Data;debilitating symptom;Dependence;Development;Diagnosis;Diarrhea;Disease;Disease Progression;Disease remission;effective therapy;Epithelium;Exanthema;Excision;experience;Flushing;Foundations;Future;gastrointestinal;gene network;Gene Targeting;Genes;Genomics;Goals;Growth;Heart failure;Histone Deacetylase Inhibitor;Hormone secretion;Hormones;Human;improved;In Vitro;in vivo;Incidence;insight;Islet Cell Tumor;knock-down;Knock-out;Ligand Binding;Lung Carcinoma;Maintenance;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Measurement;Medulloblastoma;Mentors;Mesenchymal;Metastatic Neoplasm to the Liver;microCT;migration;Modeling;mortality;mouse model;Mus;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neuroendocrine Tumors;Non-Small-Cell Lung Carcinoma;notch protein;Notch Signaling Pathway;NOTCH3 gene;novel;novel therapeutics;Nude Mice;Oncogenic;Oncology;Operative Surgical Procedures;Organ;Outcome;Outcome Measure;overexpression;Palliative Care;Pancreatic Ductal Carcinoma;Pathway Analysis;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Physicians;Play;Primary carcinoma of the liver cells;Primary Neoplasm;Production;Progression-Free Survivals;Proliferating;Proteins;public health relevance;Recurrence;reduce symptoms;Research;response;Role;Sampling;Scanning;Scientist;Seminal;Serum;side effect;Signal Pathway;Signal Transduction;Small Interfering RNA;Symptoms;Systemic Therapy;targeted treatment;Testing;Time;Tissue Microarray;Training;Transfection;treatment strategy;tumor;Tumor Biology;Tumor Cell Line;tumor growth;tumor progression;tumor xenograft;tumorigenesis;Universities;Widespread Disease;Work;Xenograft Model

PROJECT_TITLE: Characterizing the Role of NOTCH2 in Neuroendocrine Tumors


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Muscle stem cell exhaustion is one of the hallmarks of aging and leads to gradual impairment of tissue structure and function. However, the molecular mechanisms that are linked to the aging process and that contribute to stem cell exhausting have not been defined. The main focus of this proposal is to examine how increases in DNA damage (another of the hallmarks of aging) might lead to MuSC exhaustion, and to explore how the molecular mechanisms that normally limit DNA damage could be enhanced to preserved youthful MuSC structure and function.

PI_NAMEs: RANDO, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Address;Age;age related;age related decline;age-related muscle loss;aged;Aging;aging process;Area;ATR gene;Biological Models;cancer cell;Cell Count;Cell Cycle;Cell Death;Cell division;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Cellular Structures;Cessation of life;Complement;CRISPR screen;Data;Defect;DNA Damage;DNA Repair;exhaust;exhaustion;Functional disorder;gain of function;Genes;genetic approach;Genetic Models;genome integrity;genome-wide;Genomic Instability;Goals;hallmarks of aging;Health;healthspan;Homeostasis;Human;Hyperactivity;Impairment;improved;interest;Intervention;Laboratories;Laboratory Research;Life;life span;Link;loss of function;Maps;Mediator;Mitotic;Modification;Molecular;Mus;muscle aging;muscle progenitor cell;muscle regeneration;muscle repair;Muscular Atrophy;nutlin 3;old mice;Older Population;Pathway interactions;Pharmacology Study;Phenotype;phosphoproteomics;Predisposition;preservation;prevent;Prevention;Proliferating;Proteins;Regenerative capacity;Regulation;Rejuvenation;repaired;Reporting;Research;response;Risk;Role;stem cell aging;stem cell exhaustion;stem cell function;stem cell population;stem cell survival;stem cells;Structure;Testing;Time;Tissues;TP53 gene;Tumor Suppressor Proteins

PROJECT_TITLE: Genomic Instability as A Driver of Stem Cell Exhaustion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ORG_DEPT: PEDIATRICS

PHR: Lysosomal dysfunction initiates a pathogenic cascade that results in relentless neurodegeneration and premature death in neuronopathic lysosomal storage disorders. This RM1 Grant Application investigates the mechanisms and players that drive disease as a result of lysosomal dysfunction. This work holds the promise of identifying novel targets to promote brain health, combat neurodegeneration in neuronopathic lysosomal storage disorders, and halt or delay disease progression.

PI_NAMEs: COOPER, JONATHAN D;DICKSON, PATRICIA I (contact);LI, FUHAI ;SARDIELLO, MARCO

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Applications Grants;Artificial Intelligence;Astrocytes;Atlases;Automobile Driving;Behavioral;Biochemical;Biochemical Pathway;Biogenesis;Biology;Brain;brain health;Candidate Disease Gene;candidate identification;Catalogs;Cell Nucleus;cell type;Cells;Cellular Metabolic Process;cellular pathology;Cellular Stress;Central Nervous System;Central Nervous System Diseases;Cessation of life;CLN2 gene;combat;Communication;Complex;Data;Disease;disease model;disease phenotype;Disease Progression;Effector Cell;enzyme deficiency;Enzymes;exhaust;Foundations;Functional disorder;Future;Genes;Genetic;Genetic Transcription;Goals;Growth;Health;Human;human model;Individual;individual response;Induced pluripotent stem cell derived human neuron;innovation;Interphase Cell;Investigation;Knowledge;knowledge of results;Link;lipidomics;Lipids;lysosomal proteins;Lysosomes;Macrophage;Mediating;Membrane;Metabolic;Metabolic Pathway;metabolomics;Methodology;Microglia;mouse model;Mucopolysaccharidosis III B;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Nuclear;Organ;Outcome;Output;Pathogenesis;Pathogenicity;Pathologic;Pathway Analysis;Pathway interactions;Patients;Phenotype;Post-Translational Protein Processing;premature;prevent;protein protein interaction;Proteins;Proteomics;Recycling;Regulation;response;Role;Route;Signal Pathway;Signal Transduction;Site;Stress;System;Systems Biology;Systems Integration;Test Result;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;tool;Training;transcription factor;Transgenic Mice;Translational Research;Work

PROJECT_TITLE: Systems-Level Approach to Neuronopathic Lysosomal Storage Disorders


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Rare Diseases

PI_NAMEs: DING, LI  (contact)

PROJECT_TERMS: Address;African American population;Amendment;archive data;Biocompatible Materials;bioinformatics tool;Biological Assay;Board Certification;Cancer Biology;cancer genomics;cancer type;candidate selection;Categories;cell free DNA;cellular imaging;Cholangiocarcinoma;CLIA certified;CLIA certified sequencing;Clinical;Clinical Data;clinically actionable;clinically relevant;Collection;Colorectal Cancer;Communities;Computers;Data;data acquisition;Data Commons;Data Storage and Retrieval;Databases;deep sequencing;Detection;Diagnostic;Disease Progression;DNA;early onset;Eligibility Determination;Ensure;Event;Evolution;exome sequencing;follow-up;Friends;Gene Fusion;Genes;Genome;genomic data;Genomic Data Commons;Genomics;Germ Lines;Germ-Line Mutation;Goals;Guidelines;health disparity;Health Insurance Portability and Accountability Act;Human Resources;imaging study;immunogenic;Incidence;indexing;Individual;Industry Standard;Inherited;insertion/deletion mutation;Libraries;Methodology;Methods;Molecular;Monitor;mortality;Multiple Myeloma;Mutation;neoplastic cell;Normal tissue morphology;Nucleic Acids;Participant;Pathogenicity;Pathologist;patient engagement;Patients;Peptides;Physicians;Practice Management;preference;Preparation;Procedures;Process;Prognosis;programs;prospective;Proteomics;Published Comment;Publishing;Recommendation;Reporting;Research;research study;RNA;Running;Sampling;Schedule;Secure;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Specimen;statistics;Surveys;System;targeted sequencing;Testing;Time;timeline;transcriptome sequencing;tumor;tumor diagnostic;Tumor Tissue;tumor-immune system interactions;Universities;Washington;web portal

PROJECT_TITLE: Genome Characterization Unit


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative and Relevance to Public Health  This project aims to develop powerful statistical and computational methods for integrative analysis of diverse genomic data. The novel statistical methods are expected to provide genomics-based risk prediction and to gain more insights into how genomic perturbation and pathways dysfunction can lead to development of complex diseases such as Alzheimer's disease, cardiometabolic syndrome, and chronic kidney disease.

PI_NAMEs: LEE, HONGZHE  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;African ancestry;Algorithmic Software;Algorithms;Alzheimer's Disease;Area;Benchmarking;Biological;Biological Process;cardiometabolism;causal variant;Chronic Kidney Failure;Collaborations;Complex;Computer software;computerized tools;Computing Methodologies;Data;Data Analyses;data complexity;Data Set;Dependence;Development;Disease;disorder risk;Documentation;epigenomics;Ethnic Origin;Ethnic Population;experimental study;Functional disorder;gene discovery;Gene Expression;Gene Proteins;Genes;Genetic;genetic association;Genetic Risk;genetic variant;Genome;genome wide association study;genome-wide;genome-wide analysis;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;high dimensionality;high throughput technology;human disease;human genomics;improved;Individual;insight;Kidney;Kidney Diseases;Learning;learning strategy;Linear Models;machine learning method;Maps;metabolomics;Methodology;Methods;Minority Groups;Modeling;next generation sequencing;novel;Pathway interactions;Pennsylvania;Phenotype;polygenic risk score;Population;predictive modeling;programs;protein expression;Public Health;Publishing;Research Personnel;risk prediction;risk prediction model;Sampling;Signal Transduction;simulation;Software Tools;Statistical Methods;Statistical Models;statistics;Structure;Syndrome;System;theories;Tissue-Specific Gene Expression;Tissues;trait;transcriptome;transfer learning;treatment response;Universities;Variant;Work

PROJECT_TITLE: Methods for Integrative Genomic Data Analysis

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE We propose an innovative adjuvant approach to surgical treatment of contaminated high-energy open fractures using topical photodynamic therapy (PDT) to reduce the bacterial bioburden at the site of a contaminated open fracture. The scientific premise of this project is based on our preliminary research demonstrating that PDT is extremely effective at eradicating mature biofilm on metallic implants, beyond the efficacy of currently utilized adjuvant treatment modalities. In the proposed study we will optimize the formulation, light dose and timing of PDT, determine the efficacy of PDT on two different fracture stabilization strategies and develop and assess the efficacy of repeat PDT administration through a surgically placed extraosseous catheter.

PI_NAMEs: ELLIOTT, JONATHAN T (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Amber;Animal Model;Antibiotics;Bacitracin;Bacteria;bioluminescence imaging;Biomedical Engineering;Bone Tissue;Cannulas;Catheters;Cells;Cementation;Collaborations;cost;Data;Debridement;Dose;Effectiveness;efficacy evaluation;Engineering;experience;Exposure to;FDA approved;fluorescence-guided surgery;Formulation;Fracture;fracture risk;Free Radicals;Goals;high risk;Hospitalization;Human;Implant;In Vitro;in vivo;Infection;Infection prevention;infection rate;infection risk;Infrastructure;Injury;innovation;irradiation;Irrigation;Light;limb loss;Limb structure;loss of function;Mechanics;metallicity;methicillin resistant Staphylococcus aureus;Microbe;microbial;Microbial Biofilms;microbicide;Modality;Modeling;Morbidity - disease rate;multidisciplinary;Multiple Trauma;musculoskeletal injury;Nutritional;Open Fractures;Operative Surgical Procedures;optical imaging;Orthopedic Surgery;Patients;Perioperative;Photosensitizing Agents;Polymethyl Methacrylate;Porphyrins;Positioning Attribute;Postoperative Period;Povidone-Iodine;Predisposition;Preparation;Prevention strategy;PUVA Photochemotherapy;Rattus;Reactive Oxygen Species;Recovery;Research;Risk Reduction;Saline;sample fixation;Singlet Oxygen;Site;soft tissue;Soft Tissue Injuries;Source;Staphylococcus aureus;Surface;Time;tissue trauma;Titanium;Translating;Translations;Trauma;Trauma patient;treatment strategy;United States;Work;wound

PROJECT_TITLE: Adjuvant Photodynamic Therapy to Reduce Bacterial Bioburden in High-Energy Contaminated Open Fractures

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Prevention;Rare Diseases;Social Determinants of Health

PI_NAMEs: DRAKE, BETTINA F. (contact)

PROJECT_TERMS: Address;Adult;Advocate;Area;Behavioral Research;Cancer Center;cancer education;cancer genomics;cancer health disparity;Cancer Patient;cancer prevention;Cholangiocarcinoma;Collaborations;Communication;community engagement;Community Outreach;community partners;Consent;Data Collection;Decision Aid;Decision Making;Development;Diagnosis;Diffusion;Disclosure;early onset colorectal cancer;Education;Education and Outreach;Ensure;Ethical Issues;ethical, legal, and social implication;Ethicists;Ethics;Evaluation;experience;Feedback;follow-up;formative assessment;Future;genetic testing;Genome;Genomic medicine;Genomics;Goals;Guidelines;high risk;implementation framework;implementation measures;implementation science;implementation strategy;improved;innovation;Intervention;Interview;Lead;Malignant Neoplasms;Methodology;Minority;Minority Groups;Mission;Multiple Myeloma;Online Systems;Outcomes Research;Participant;Patient Education;patient engagement;patient outreach;Patient Preferences;Patients;preference;Prevention;Process;programs;Randomized;randomized trial;Randomized, Controlled Trials;rare cancer;Recommendation;recruit;Research;Research Ethics;Rural;Rural Population;Sampling;Testing;trial comparing;tumor;Underrepresented Populations;Underserved Population;understudied cancer;Universities;Vision;Washington;web based decision aid;Work

PROJECT_TITLE: Engagement Optimization Unit


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Kidney Disease;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: This K26 grant is for support of Dr. Michal L. Melamed in her mentoring of the next generation of Pediatric and Adult Kidney Health researchers. Dr. Melamed is an award- winning mentor with a long history of successfully mentoring individuals from Diverse Backgrounds. This award will allow her to devote more time to mentoring multiple trainees, including individuals from groups Underrepresented in Medicine, into academic careers in clinical research in Kidney Health.

PI_NAMEs: MELAMED, MICHAL L (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adult;Advisory Committees;Alkalies;American;Appointment;Area;Attention;Award;Biological Markers;Black race;bone;bone health;Cardiovascular Diseases;career;career development;Caring;Child;Childhood;Cities;Clinical;clinical epidemiology;Clinical Research;Clinical Trials;Collaborations;college;Congresses;Data;design;doctoral student;Educational workshop;Equity;ethnic minority;experience;Faculty;Fellowship;Fellowship Program;Funding;Grant;Health;health care delivery;health equity;Health equity research;Hematology;Hemodialysis;Home;Hospitals;improved;Individual;innovation;Institution;interest;Internal Medicine;International;Joints;Kidney;Kidney Diseases;Leadership;leadership development;Literature;Medical;Medical center;medical schools;Medical Students;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic acidosis;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;New York;next generation;novel;Paper;Pathway interactions;patient population;Patients;peer coaching;Peripheral;Personal Satisfaction;Positioning Attribute;Postdoctoral Fellow;potassium citrate;pre-doctoral;programs;Publishing;Qualifying;racial minority population;randomized placebo controlled trial;randomized, clinical trials;Recommendation;Recording of previous events;recruit;Renaissance;Reporting;Research;Research Personnel;Research Training;Resolution;responsible research conduct;Role;Science;secondary analysis;skills;social health determinants;Societies;Sodium Bicarbonate;Spottings;Students;symposium;Time;TNFSF15 gene;Training;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;urologic;Vascular calcification;Woman;women faculty;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Mentoring in Kidney Health to Improve Equity


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE  Radiation therapy plays an integral role in treating human head and neck squamous cell carcinoma. However, head and neck radiation therapy is associated with significant toxicity in the oral mucosa, termed radiation-induced oral mucositis. The overall goal of this project aims to develop novel therapeutic strategies that will prevent or reduce radiation-induced oral mucositis by transiently enhancing p53-mediated signaling in response to acute DNA damage in normal oral mucosa.

PI_NAMEs: LEE, CHANG-LUNG  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Acute;Affect;Alleles;Blood capillaries;Body Weight;Body Weight decreased;C57BL/6 Mouse;Cell Cycle Arrest;Cell Death;Cell Lineage;Cell Proliferation;Cell Survival;Cells;clinical development;Data;Defect;Dilatation - action;DNA Damage;Dose Limiting;Epithelial Cells;Epithelium;Exhibits;experimental study;G2/M Checkpoint Pathway;GADD45A gene;gain of function;Genetic Transcription;Genetically Engineered Mouse;genome integrity;Goals;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Histopathology;HPV negative;Human;Impairment;in vivo;Incidence;Inflammation;inhibitor;Injury;insight;Intake;irradiation;knock-down;Knockout Mice;loss of function;Maintenance;Malignant Neoplasms;Mediating;Metabolic;mimetics;Mitosis;Mitotic;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Myeloid Cells;Natural regeneration;Normal tissue morphology;novel;novel therapeutic intervention;Nutritional status;opioid use;Oral;oral cavity epithelium;oral mucositis;Oral mucous membrane structure;Patient-Focused Outcomes;Patients;Persons;pharmacologic;Play;prevent;Radiation;Radiation Injuries;Radiation Protection;radiation response;Radiation therapy;Recovery;response;Role;Signal Transduction;small hairpin RNA;small molecule;Somatic Cell;Stress;Superoxide Dismutase;Testing;Therapeutic;Toxic effect;TP53 gene;Transactivation;Transplantation;treatment response;tumor;United States;Vascular Endothelial Cell

PROJECT_TITLE: Radioprotective effect of p53 against oral mucositis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE It is imperative to understand the underlying sources of the large health disparities among individuals from different racial and ethnic groups living in the United States. Complex relationships between genetics, individual behavior, socioeconomic status and the environment influence health. The goal of the CAST (Center for Admixture Science and Technology) program is to improve the utility of genome science for all populations living in the United States.

PI_NAMEs: FRAZER, KELLY A;GYMREK, MELISSA ;OHNO-MACHADO, LUCILA  (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Admixture;Affect;African;algorithm development;Algorithms;All of Us Research Program;American;American Indians;Asian population;Awareness;Behavior;Benchmarking;Biology;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Categories;Characteristics;Clinical;cluster computing;cohort;Complex;Data;data privacy;data sharing;design;Diagnosis;disease model;Electronic Health Record;Environment;ethnic minority population;Ethnic Origin;Ethnic Population;European;Exclusion;follow-up;Genes;Genetic;Genetic Determinism;genetic information;Genetic Variation;Genome;genome sciences;genome wide association study;Genomic medicine;Genomics;Goals;Health;health determinants;health disparity;health economics;health outcome disparity;Health Surveys;Healthcare;Heart;improved;Incidental Findings;Individual;innovation;Intervention;Joints;Language;large datasets;Major Histocompatibility Complex;Malignant Neoplasms;Maps;Medical;Medical Genetics;medical schools;Methods;Minority;Minority Groups;Modeling;Morbidity - disease rate;mortality;Native Americans;Natural Language Processing;novel;novel strategies;Outcome;Participant;Pathogenicity;Persons;Phenotype;Policies;polygenic risk score;poor health outcome;Population;Population Heterogeneity;Poverty;prevent;privacy protection;Prognosis;programs;prospective;Publishing;Race;racial minority;racial population;Recommendation;Reporting;repository;Research;Research Personnel;Risk;risk prediction;scalable algorithms;Science;Single Nucleotide Polymorphism;Site;Social Adjustment;social determinants;social factors;social health determinants;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Source;statistics;Tandem Repeat Sequences;Techniques;Technology;tool;trait;United States;Variant;Veterans

PROJECT_TITLE: Genetic & Social Determinants of Health: Center for Admixture Science and Technology


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research in the first phase of this proposal is to investigate a new methodology to capture and define a novel ultrashort circulating tumor DNA species in the plasma of lung cancer patients. In the second phase, the usage of various other molecules additional to the ultrashort DNA species in biofluids will be explored in hopes to detect multiple cancer types with liquid biopsy. These findings will contribute to improved clinical outcomes for cancer patients by leading to the development of new liquid biopsy approaches for improved detection and treatment monitoring.

PI_NAMEs: CHENG, JORDAN C (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Animals;anti-cancer research;Apoptosis;Axilla;Base Pairing;Bioinformatics;Biological;Biological Markers;Biological Models;Biology;cancer cell;Cancer Center;Cancer Detection;cancer genetics;Cancer Patient;cancer type;career;Cell Culture Techniques;cell free DNA;Cerebrospinal Fluid;Circulation;Clinical;cohort;Complex;Comprehensive Cancer Center;CRISPR/Cas technology;Data;deep sequencing;design;Detection;Development;Disease Progression;Disseminated Malignant Neoplasm;DNA;DNA analysis;DNA purification;DNA sequencing;Doctor of Philosophy;ds-DNA;Early Diagnosis;electric field;Elements;Epidermal Growth Factor Receptor;Excision;Exclusion;experimental study;extracellular;Genetic;Genomics;Genotype;Goals;Head and neck structure;improved;Incisional Biopsy;Inflammatory Response;insight;interest;Jordan;Length;Leukocytes;Libraries;liquid biopsy;Machine Learning;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mentorship;Methodology;Methods;Methylation;methylation pattern;Modeling;Modernization;Monitor;mutant;Mutate;Mutation;Nature;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Oncology;Oral;Organoids;Outcome;Patients;Pharmacotherapy;Phase;Plasma;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;professor;Protocols documentation;Regulatory Pathway;Research;Research Project Grants;saliva sample;Sampling;School Dentistry;Screening for cancer;Selection Bias;Single-Stranded DNA;skills;Testing;theories;Therapeutic;Tissues;Training;tumor;tumor DNA;tumor progression;Urine;Validation;Work

PROJECT_TITLE: Cell-free DNA Analysis for Liquid Biopsy of Cancer


NIH_SPENDING_CATS: Brain Disorders;Cancer;Clinical Research;Genetics;Lung;Lymphatic Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Lymphangioleiomyomatosis (LAM) is a progressive lung disease which can lead to respiratory failure and potential death. LAM has been treated with drugs targeting the mammalian target of rapamycin (mTOR) pathway however there are alternative pathways important in the pathogenesis of the disease. Therefore, this proposal will further delineate the role of the HMGA2 pathway in the disease of LAM.

PI_NAMEs: D'ARMIENTO, JEANINE M (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Age;Architecture;Behavior;Biological Markers;Blood;BMP5 gene;Candidate Disease Gene;cell behavior;Cell Differentiation process;cell growth;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;Clinical;cohort;Computational Technique;CRISPR/Cas technology;Diagnosis;Disease;disease phenotype;Disease Progression;Drug Targeting;FRAP1 gene;Gender;Gene Expression;Genes;Genetic;genome editing;Growth;Histologic;HMGA2 gene;human induced pluripotent stem cells;IGFBP2 gene;IGFBP4 gene;IGFBP5 gene;In Vitro;indexing;Individual;induced pluripotent stem cell;Knock-out;Laboratories;Lung;Lung Diseases;lung lesion;Lung Lymphangioleiomyomatosis;Lymphangioleiomyomatosis;Measures;Medical;Mesenchymal;Messenger RNA;Modeling;molecular marker;mouse model;mRNA Expression;Mus;Mutation;neoplastic cell;new therapeutic target;novel;Oncogenic;Participant;Pathogenesis;Pathway interactions;patient subsets;Patients;pharmacologic;Prognosis;Proliferating;Publishing;Respiratory Failure;response;Role;Sampling;Serum;Severities;Signal Pathway;Smooth Muscle Myocytes;Subcutaneous Injections;Tail;Techniques;Testing;Therapeutic Intervention;transcription factor;transcriptome sequencing;TSC2 gene;Tuberous Sclerosis;tumor;Tumor Cell Line;tumor initiation;tumor microenvironment;tumorigenesis;validation studies;Veins;Whole Blood

PROJECT_TITLE: Molecular Biomarkers in pathogenesis of Lymphangioleiomyomatosis (LAM)

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Machine Learning and Artificial Intelligence;Patient Safety;Prevention;Rural Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Apparent treatment resistant hypertension (aTRH) describes a subset of hypertensive individuals with elevated blood pressure despite use of multiple antihypertensive medications, and is associated with very poor long- term prognosis. Currently, there is no conclusive way to identify hypertension patients who will ultimately develop aTRH, or determine which patients will experience the adverse cardiovascular outcomes associated with hypertension. This project will identify hypertension subpopulations and characteristics associated with aTRH and adverse cardiovascular outcomes, and evaluate prediction of aTRH and adverse cardiovascular outcomes by geographic regions.

PI_NAMEs: MCDONOUGH, CAITRIN W (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Acute myocardial infarction;Adult;Adverse event;Algorithms;All of Us Research Program;analytical method;Anti-Hypertensive Agents;Biochemical;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Characteristics;Clinical;Complex;computable phenotypes;Data;Data Reporting;Data Set;Databases;design;Diagnosis;Early Diagnosis;Early identification;Electronic Health Record;Enrollment;Exclusion;genomic data;Genomics;Geographic Locations;Goals;Healthcare;Heart failure;high risk;Hypertension;hypertensive;improved;Individual;Institution;interpatient variability;Knowledge;machine learning model;medication nonadherence;Mentored Research Scientist Development Award;mortality;National Heart, Lung, and Blood Institute;Organ;Outcome;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;Prevalence;prevent;Prognosis;Regression Analysis;Reporting;Research;Research Personnel;Resistant Hypertension;response;Risk;Risk Factors;rural area;Selection for Treatments;sex as a biological variable;Signal Transduction;Stroke;Surveys;Testing;United States;wearable device;Work

PROJECT_TITLE: Hypertension Prediction and Identification in All of Us


NIH_SPENDING_CATS: Clinical Research;Health Services;Kidney Disease;Pediatric

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Michelle Denburg, MD, MSCE is an Associate Professor of Pediatrics and Epidemiology at the University of Pennsylvania Perelman School of Medicine (PSOM) and is a practicing pediatric nephrologist at the Children's Hospital of Philadelphia (CHOP). Dr. Denburg is committed to and has a long-standing track record of research and career mentoring across the early career spectrum, from students to junior faculty. Support from the K26 award will help sustain her active mentoring program and expand her mentoring capacity, with a focus on mentoring of individuals underrepresented in medicine.

PI_NAMEs: DENBURG, MICHELLE  (contact)

PROJECT_TERMS: Achievement;Adult;American;Ancillary Study;Appointment;Award;Awareness;Biomedical Research;Biometry;bone;bone health;career;Career Choice;career development;Career Mobility;Child Care;Child Welfare;Childhood;Chronic Disease;Chronic Kidney Failure;clinical center;clinical epidemiology;Clinical Research;Collaborations;Databases;design;Development;Discipline;Disease;doctoral student;Educational Curriculum;Electronic Health Record;Endocrinology;Endowment;Environment;Epidemiology;equity, diversity, and inclusion;evidence base;Exposure to;Faculty;Fracture;Funding;Gastroenterology;Goals;graduate student;Grant;Health;Health Policy;Homeostasis;improved;Individual;innovation;Institution;Interdisciplinary Study;interest;Intervention;Kidney;Kidney Calculi;Kidney Diseases;Leadership;Master of Science;medical schools;Medical Students;Medicine;Mentors;Mentorship;Metabolism;mid-career faculty;Minerals;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Outcome;patient engagement;patient oriented;patient oriented research;pediatric department;Pediatric Hospitals;Pediatric Research;Pediatrics;peer coaching;Pennsylvania;Philadelphia;Policy Research;Population;Postdoctoral Fellow;pre-doctoral;Process;programs;Prospective, cohort study;Rare Diseases;recruit;Renal glomerular disease;Research;Research Personnel;Resources;Role;role model;Scholarship;Science;Scientist;skills;Societies;stem;Students;summer student;Training;Training and Infrastructure;Training Programs;Translational Research;translational research program;undergraduate student;United States National Institutes of Health;Universities;Urology;Vitamin D;young adult

PROJECT_TITLE: Mentoring of Early Career Researchers from Diverse Backgrounds


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Regenerative Medicine;Social Determinants of Health;Wound Healing and Care

ORG_CITY: Somerville

ORG_NAME: SANAHEAL, INC.

PHR: NARRATIVE Chronic diabetic wounds such as diabetic foot ulcers (DFU) are one of the major clinical complications in patients with diabetes and incur substantial and rapidly growing clinical and economic burdens in aging societies around the world. During the prior development (Phase I-equivalent), the collaborative team developed and evaluated a proof-of-concept prototype of a strain-programmed bioadhesive patch for accelerated diabetic wound healing. In the proposed project, we will continue optimization and validation of the strain-programmed patch based on pre- clinical and GLP testing in compliance with FDA regulatory guidance toward the FDA IDE approval in advance of a pivotal clinical trial for the ultimate regulatory clearance and commercialization.

PI_NAMEs: YUK, HYUNWOO  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Address;Adhesives;African American population;Aftercare;Aging;aging population;Amputation;Biocompatible Materials;Biological Products;biomaterial compatibility;burn wound;Chronic;chronic wound;Clinical;clinical trial protocol;clinical trial readiness;Clinical Trials;commercialization;cost;Cutaneous;db/db mouse;design;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;diabetic wound healing;Economic Burden;economic cost;Ensure;Face;Family suidae;FDA approved;Frequencies;Future;Growth Factor;Guidelines;healing;Healthcare Systems;Hispanic Populations;Human;humanized mouse;Impaired wound healing;in vivo;Industry;Intervention;Light;Low income;Lower Extremity;manufacture;mechanical properties;Mechanics;meetings;Modeling;mouse model;Outcome;Patients;Performance;Pharmaceutical Preparations;Phase;Platelet-Derived Growth Factor;porcine model;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical study;Preparation;Prevalence;prototype;Quality of life;re-epithelialization;Recombinant Growth Factor;regenerative;Reporting;Risk;scaffold;Shapes;Skin;Skin graft;skin wound;Small Business Innovation Research Grant;Societies;Technology;Testing;Therapeutic;Tissue Adhesives;Treatment Cost;Treatment Efficacy;treatment optimization;Ulcer;Underserved Population;United States;Validation;Veterans;Work;wound;wound closure;wound healing

PROJECT_TITLE: Strain-Programmed Bioadhesive Patch for Enhanced Diabetic Wound Healing


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Sleep Research;Suicide

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative Adolescent suicide has been linked with sleep disruptions. Adolescent social media use has been tied to both sleep and mental health difficulties. The present research examines how social messaging may serve to structure adolescent diurnal rhythms and impact later suicidal thoughts and behaviors.

PI_NAMEs: NUGENT, NICOLE R (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Accident and Emergency department;Acute;Adolescence;Adolescent;adolescent mental health;adolescent suicide;Affect;Affective;Age;Behavior;Biological Markers;Caring;Cognitive;COVID-19;Deterioration;Diagnostic;Distress;Diurnal Rhythm;Ecological momentary assessment;emotion dysregulation;Emotional;Epidemic;Facebook;Feeling suicidal;fitbit;follow-up;Hour;Impairment;in vivo;Individual;innovation;Instagram;Intervention;Interview;Knowledge;Linguistics;Link;Measurement;Measures;media use;Mental Health;Methods;Modeling;Negative Valence;Neurobiology;Participant;Patient Self-Report;Pattern;Perception;Phase;post-pandemic;pre-pandemic;prediction algorithm;Prevention;Procedures;Process;Research;Risk;Risk Factors;Risk Marker;Role;Sampling;Self-Injurious Behavior;Sleep;Sleep Deprivation;Sleep disturbances;sleep health;sleep onset;social;social media;Stress;Structure;suicidal;suicidal adolescent;suicidal behavior;Suicide;suicide rate;Symptoms;Teenagers;Testing;Text;Text Messaging;Thinking;Time;wearable device

PROJECT_TITLE: Social Media Use, Sleep, and Suicidality in Adolescents


NIH_SPENDING_CATS: Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Recruitment and retention of women and underrepresented minorities into academic gastroenterology (GI) has been a major challenge for decades. NIDDK has supported efforts by the American Gastroenterology Association (AGA) from 2012 through 2023 through the R25 mechanism. I have been involved in these efforts for decades at the local (UCSD) and national levels. The latest of these R25 DK118761 AGA - Fostering Opportunities Resulting in Workforce and Research Diversity (FORWARD) provides a structured mentoring program for junior GI faculty. The program has provided structured mentoring to 20 junior academic GI’s and has received an excellent score for the next 5-year cycle renewal. I have been involved in these efforts for decades at the local (UCSD) and national levels. This award will provide dedicated salary support to allow this investigator to reallocate effort to these diversity initiatives both at UCSD and with the AGA.

PI_NAMEs: RIVERA-NIEVES, JESUS  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Academia;Address;Admission activity;African American;African American population;American;Area;Association of American Medical Colleges;Award;Black race;career;Clinical;clinical practice;Dedications;Department chair;Digestive System Disorders;Disadvantaged;Disparity;disparity reduction;Education;Education Projects;Educational Curriculum;Faculty;falls;Family;Female;Fostering;Free Will;Funding;Future;Gastroenterology;Grant;health equity;Hispanic;Individual;Institution;Investments;Latino;Leadership;Measures;Medical;Medical Students;Medicine;Mentors;Minority Groups;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Parents;patient engagement;Physicians;Play;Privatization;Productivity;Professional Organizations;Program Development;programs;Qualifying;Recording of previous events;recruit;Request for Applications;Research;Research Personnel;response;Role;Schedule;Scientist;Security;Senior Scientist;Siblings;skills;Structure;success;Surveys;Teacher Professional Development;third grade;Time;Training;training opportunity;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Vacuum;volunteer;Wages;Woman

PROJECT_TITLE: Enhancing Mentoring of Diverse Early Career Researchers


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Having “the talk”—discussing racism and buffering children from racist experiences, is a task  shouldered by families of color; seldom do White parents have “the talk” with their children—critical and honest  conversations about race and racism, and the role that they have in remedying the pervasive legacy of racism  and eliminating discrimination and prejudice. This study focuses on the role that families can have in  addressing racism, an important yet under-leveraged point of intervention, and tests the efficacy of a multi module app in promoting productive, color-conscious, and anti-racism conversations between parents and their  children. It is hypothesized that the app-based “Color Brave” intervention we propose will reduce racial bias  and the perpetration of racism, and promote support for restorative societal policies—all of which are important  to address racial inequities in health.

PI_NAMEs: CHAE, H. DAVID  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;anti-racism;Attention;Attitude;authority;Behavior;Buffers;Child;children of color;Color;Color blindness;Complex;Conscious;Consensus;Data;Development;Discrimination;Disparity;early childhood;Educational process of instructing;efficacy evaluation;efficacy testing;elementary school;Empathy;Equity;experience;experimental study;Family;Focus Groups;follow up assessment;follow-up;Frequencies;Friendships;Goals;Happiness;Health;Health Hazards;health inequalities;improved;Inequity;innovation;insight;interest;intergenerational;Intervention;intervention delivery;intervention effect;intervention program;Interview;Knowledge;Learning;Measures;member;Methods;Modeling;Outcome;parent-child communication;parental role;parenting intervention;Parents;peer;Perception;Play;Policies;Prejudice;Preparation;prevent;Probability;Problem Solving;Process;Productivity;programs;Public Health;Race;racial bias;racial discrimination;racial disparity;racial diversity;Racial Equity;racial identity;racial population;racism;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Design;Role;Sampling;Science;second grade;Self Concept;Shapes;Shoulder;social;Social Impacts;Socialization;Societies;Stress;Structure;Testing;therapy design;Time;tool;transmission process;trial design;virtual;Waiting Lists;Well in self;Work

PROJECT_TITLE: Promoting Color Brave Conversations in Families: A Public Health Strategy to Advance Racial Equity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project will have adequate power and collaborative input to determine the best pharmacological therapy for NOWS, comparing morphine, methadone, and buprenorphine in a head to head trial for the first time. This site, by virtue of its large diverse, rural population, its previous research experience in NOWS, opioid use, pk/pd modeling, and implementation science, and support from the Translational Research Institute and CTSA, is well positioned to become an active member of this collaborative effort. This site will advance NIH's mission to effectively and safely treat NOWS and participate in all aspects of this important comparative effectiveness trial.

PI_NAMEs: HALL, RICHARD WHITTINGTON (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;Academic support;Admission activity;adverse childhood events;African American;Alabama;antenatal;Area;Arkansas;arm;Awareness;Beds;Behavioral;Blood specimen;Brain;Buprenorphine;Caring;Case Manager;Child;Childhood;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Research;clinical research site;community advisory board;comparative effectiveness trial;compare effectiveness;Complex;cost;Data;Data Coordinating Center;Development;Discipline of obstetrics;Dose;Drug Kinetics;Drug Modulation;effectiveness clinical trial;effectiveness evaluation;Electronic Mail;Enrollment;Ensure;Environment;environmental stressor;evidence base;experience;Exposure to;Faculty;Family;financial incentive;follow-up;Funding;Head;Helping to End Addiction Long-term;Hispanic;Home;Hospitals;implementation science;in utero;Incentives;Infant;Infrastructure;innovation;Insurance;Leadership;Length of Stay;Long-Term Effects;Medical;member;Mental Health;Methadone;Mission;Modeling;Morphine;Mothers;Multicenter Trials;Neonatal;Neonatal Abstinence Syndrome;Neonatal Intensive Care Units;neonate;Neonatology;neurobehavioral;Newborn Infant;Opioid;opioid exposure;opioid use;opioid use disorder;opioid withdrawal;Outcome;Outpatients;Pain Measurement;pain score;Parents;Participant;participant enrollment;Pediatric Hospitals;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Policies;polysubstance use;Population;Positioning Attribute;Pregnant Women;prenatal;prescription opioid;Privatization;programs;Prospective, cohort study;protocol development;Protocols documentation;Provider;Psychiatry;psychologic;Psychometrics;public health insurance;Publications;recruit;Research;Research Institute;Research Personnel;response;Rural;Rural Population;Sample Size;Schedule;Science;Sister;Site;social;Substance Use Disorder;Telemedicine;Testing;Time;Translational Research;Travel;treatment effect;United States National Institutes of Health;Universities;Update;Weaning;Woman;Women's Health;Work

PROJECT_TITLE: HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial Clinical Site


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Hematology;Infectious Diseases;Sepsis

PHR: PROJECT NARRATIVE  Our group seeks to understand why and how some patients, even after being ‘healed’ and discharged from the hospital, continue to suffer poor health and a high rate of long-term death. Our characterization of how the mitochondrion restructures itself as an adaptive mechanism to mitigate the acute insult and ‘learn’ so as to protect the cell against any future environmental threat may provide a biological explanation for the elevated long-term death experienced by our patients. Together our results will provide foundational knowledge to support the development of innovative diagnostic tools and novel biologic therapeutics that compliment contemporary sepsis care to improve survival. In doing so we will address one of the most pressing needs in the care of septic patients.

PI_NAMEs: ROSENGART, MATTHEW RANDALL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;American;Animals;Anxiety;Biological;Biological Response Modifier Therapy;Biology;Brain;burden of chronic illness;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;calcium uniporter;Caring;cell injury;Cell Physiology;Cell Respiration;Cell Survival;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Complex;cytokine;Cytoprotection;Development;diagnostic tool;Equilibrium;Exhibits;experience;Family member;fear memory;fitness;Functional Magnetic Resonance Imaging;Future;Generations;healing;Health;Heart;Heart failure;Hippocampus;Homeostasis;hospital readmission;Hospitalization;Hospitals;Human;Immune;Impaired cognition;improved;in vivo;Infection;Inflammatory;innovation;intraperitoneal;Kidney;Knowledge;Learning;Life;Link;Liver;Lower respiratory tract structure;Lysosomes;Mediating;Membrane Potentials;Mental disorders;Messenger RNA;Metabolism;Mitochondria;mitochondrial membrane;Modeling;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Myocardial Infarction;neurocognitive disorder;novel;Organism;Pathway interactions;Patients;Phenotype;preservation;Production;protein degradation;psychologic;Recovery;Recurrence;response;Sampling;Sepsis;septic patients;stoichiometry;Stress;Stroke;Structure;Survivors;systemic inflammatory response;Tissues;Trauma;uptake;vasogenic edema;Work

PROJECT_TITLE: Calcium homeostasis and cellular fitness in sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: VALHALLA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Peripheral sensory neurons play important roles in the function and dysfunction of pancreatic insulin-producing β cells. The proposed project aims at elucidating the  molecular basis of sensory neuromodulation of β cells. If successful, these studies will provide valuable biological clues that can be harnessed to design neuropharmacology- and/or neuromodulation-based therapies to enhance functional β-cell mass in patients with diabetes.

PI_NAMEs: EL  OUAAMARI, ABDELFATTAH  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Affect;Afferent Neurons;Autoimmunity;base;Beta Cell;Biological;Biological Assay;Biology;blood glucose regulation;Body Composition;Calcium;Cell Physiology;Cell Proliferation;cell regeneration;Cells;Cellular Stress;Central Nervous System;Chemicals;Chest;Clinical;Coculture Techniques;Data;deep sequencing;Denervation;design;Detection;Development;Diabetes Mellitus;diabetic;Disease;Efferent Neurons;Energy Metabolism;Etiology;Excision;Exhibits;experimental study;Failure;Female;FGF3 gene;Foundations;Functional disorder;functional restoration;Ganglia;Gene Expression;Genetic;genetic approach;Glucagon;glucagon-like peptide 1;Glucose;Goals;Gonadal Steroid Hormones;Growth Factor;Harvest;high resolution imaging;Hormones;Human;Hyperplasia;imaging modality;immunodeficiency;Immunofluorescence Microscopy;In Vitro;in vivo Model;Individual;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Link;Literature;live cell imaging;male;Maps;Mediating;men;Metabolic;Methods;Modality;Modeling;Molecular;mouse model;Mus;nerve supply;neural;neurochemistry;neuron component;Neurons;Neuropeptides;Neuropharmacology;neuroregulation;neurosensory;Nociceptors;Nodose Ganglion;novel;Operative Surgical Procedures;Pain;pain perception;Pain Threshold;Pancreas;Patients;Perception;Peripheral;pharmacologic;Play;Prevalence;Progesterone;Proliferating;Proteomics;Recombinants;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Sensory;Sensory Ganglia;sensory mechanism;sensory system;sex;Sex Bias;Sex Chromosomes;Sex Differences;Signal Pathway;Signaling Molecule;Specimen;Spinal;Spinal cord injury;Spinal Ganglia;Spinal nerve structure;Streptozocin;Structure of beta Cell of islet;System;Systems Biology;Techniques;Testosterone;Time;Tissues;transcriptome sequencing;Translational Research;type I and type II diabetes

PROJECT_TITLE: Sensory Neuromodulation of Pancreatic Beta Cells

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Nora Franceschini, MD MPH, is a nephrologist and an epidemiologist with a 20-year experience conducting multidisciplinary studies in chronic kidney disease and mentoring graduate students and early-stage investigators, including those from underrepresented groups. The goal of this award is to increase mentoring of junior investigators from underrepresented groups in science on molecular epidemiology research of chronic kidney disease in diverse populations, through activities based on her research program and the University of North Carolina graduate school.

PI_NAMEs: FRANCESCHINI, NORA  (contact)

PROJECT_TERMS: Adult;Affect;agricultural community;American Heart Association;American Indians;Area;Atherosclerosis Risk in Communities;Award;base;Black Populations;burden of illness;Cardiovascular Diseases;cardiovascular disorder epidemiology;career;Cause of Death;Cessation of life;Chronic Kidney Failure;Cohort Studies;Data;Dedications;design;Developing Countries;disability;Disease;Diverse Workforce;Education;Educational process of instructing;Enrollment;Epidemiologist;Epidemiology;epidemiology study;Epigenetic Process;Etiology;experience;Faculty;Funding;Genetic;genetic epidemiology;Genetic Research;genetic variant;Goals;graduate school;graduate student;Grant;Heart;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;improved;Individual;International;Intervention;Kidney;Latino Population;Leadership;Learning;meetings;member;Mentors;Mentorship;metabolomics;Methods;Molecular;Molecular Epidemiology;molecular marker;multidisciplinary;Nephrology;next generation;North Carolina;Paper;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;premature;Prevention;Principal Investigator;programs;Proteomics;Public Health;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Support;Risk;Risk Factors;Science;Scientist;skills;Societies;Source;Therapeutic;Time;tool;Training;Trans-Omics for Precision Medicine;transcriptome;Underrepresented Populations;United States National Institutes of Health;Universities;Women's Health;Work;Writing

PROJECT_TITLE: Mentored Training in Molecular Epidemiology of Chronic Kidney Disease in Diverse Populations


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Services;Liver Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: RIA TECHNOLOGY MANAGEMENT INC.

PHR: PROJECT NARRATIVE The Ria Treatment Platform is an innovative model for personalized alcohol use disorder treatment using telemedicine that includes anti- craving medications that are managed by expert physicians and nurse practitioners with psychosocial treatment delivered by recovery coaches. The RTP technology system collects objective measures of drinking behavior with breathalyzers synced to our smartphone app and integrates group and peer support within a HIPAA-compliant environment. This project will build upon this successful technology by 1) identifying prospective patients by reviewing medical records for evidence of possible liver injury from alcohol and 2) conducting the first randomized clinical trial of the Ria Treatment Platform.

PI_NAMEs: MENDELSON, JOHN E. (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Adult;Age;Alanine Transaminase;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol screening;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Aspartate Transaminase;Bacterial Artificial Chromosomes;Biological Assay;Cellular Phone;Clinical Trials;Computer software;Controlled Study;craving;Data;Death Rate;Disease;drinking;drinking behavior;Early identification;Early treatment;efficacious treatment;electronic health record system;Engineering;Enrollment;Ensure;Environment;Evidence based treatment;Excess Mortality;Failure;Fatigue;Gamma-glutamyl transferase;Health;health application;Health Insurance Portability and Accountability Act;Health Services Accessibility;Heavy Drinking;improved;Incidence;Individual;innovation;Institutional Review Boards;Insurance Carriers;Intervention;Laboratories;Link;Liver;Liver diseases;Liver Function Tests;liver injury;Location;Mass Screening;Measures;Medical Records;medication compliance;Medication Management;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nurse Practitioners;Outcome;Outcome Measure;participant enrollment;patient engagement;Patients;peer support;personalized management;Persons;Pharmaceutical Preparations;Phase;Physicians;Prevalence;primary outcome;Privatization;prospective;psychosocial;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Records;Recovery;Risk;Safety;safety assessment;screening;Secure;Serum;Signal Transduction;smartphone application;social stigma;Symptoms;System;Technology;technology platform;telehealth;Telemedicine;Testing;Time;tool;Universities;Validation;Waiting Lists;week trial;Work

PROJECT_TITLE: A Telehealth Intervention to Increase Screening and Treatment for Alcohol Use Disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Rumination Focused Cognitive Behavioral therapy (RFCBT) is an emerging treatment that is  designed to improve depression symptoms and reduce the ruminative habit, and modifying a risk for  depression recurrence (RDR). Neural networks associated with rumination and compensation for  rumination are also targeted with RFCBT.

PI_NAMEs: LANGENECKER, SCOTT A (contact);WATKINS, EDWARD

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Aftercare;Age;Alternative Therapies;Anxiety Disorders;arm;Behavioral;Brain;children's depression rating scale;cingulate cortex;Clinical;cognitive control;Cognitive Therapy;Compensation;Data;depressive symptoms;design;dimensional analysis;Dimensions;Disease;Disease remission;distraction;Dose;Educational process of instructing;Emotions;Enrollment;Evaluation;Feeling;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;generalized anxiety;Goals;Grant;Habits;high risk;improved;indexing;Inferior frontal gyrus;Instruction;Knowledge;Left;Link;Maintenance;Major Depressive Disorder;Manuals;Measures;Mental Depression;Morbidity - disease rate;network dysfunction;neural;neural circuit;neural network;neuroregulation;novel;Outcome;Pathway interactions;Patient Self-Report;Patients;Pattern;Persons;Phase;pilot trial;Problem Solving;Psyche structure;Puberty;Randomized;recruit;Recurrence;recurrent depression;Relapse;relapse prevention;Relaxation Therapy;Resistance;response;Rest;Risk;Risk Reduction;rumination;Sampling;Signal Transduction;Site;social anxiety;Specificity;Symptoms;targeted biomarker;therapy development;Thinking;treatment response;Work;Youth

PROJECT_TITLE: Developing rumination-focused treatment to reduce risk for depression recurrence (RDR) in adolescence


NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Immunogenomic variation plays a pervasive role across organ systems and is implicated in myriad conditions, including adverse drug reactions and infectious, oncologic, cardiovascular, and neurologic diseases. The proposed research is relevant to public health because it has the potential to accelerate genomic research on the biology of disease and create a model by which future researchers investigate the impact of immunogenomic variation. Thus, the proposed research is relevant to the part of the NIH mission that pertains to reducing the public health burden of a wide variety of disease and adverse drug reactions.

PI_NAMEs: KARNES, JASON HANSEN (contact);WHEELER, TRAVIS JOHN

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Acceleration;Address;adverse drug reaction;African;African American;All of Us Research Program;Alleles;American;Antigen Presentation;Antigenic Variation;Attention;Binding;biobank;Bioinformatics;Biological;Biology;biomarker identification;Body System;Cardiovascular Diseases;Catalogs;Characteristics;Classification;combat;combinatorial;Coupled;Data;data acquisition;Data Set;Development;Diagnosis;Digit structure;Disease;Disease stratification;Disease susceptibility;disorder risk;Disparate;Disparity;diverse data;DNA;Electronic Health Record;ethnic disparity;Ethnic Population;European;European ancestry;Future;Gender;Genes;Genetic;Genetic Variation;Genome;genome sequencing;genome wide association study;genomic locus;Genomics;health inequalities;Hispanic;HLA Antigens;Human;human disease;Immune;Immune response;Immunogenomics;immunoregulation;improved;Individual;Infection;innovation;interest;Investigation;Knowledge;Latino;learning strategy;Literature;Machine Learning;machine learning method;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Methods;Mission;Modeling;Nervous System Disorder;Neural Network Simulation;novel;novel strategies;Organ Donor;Participant;Pathogenesis;Patients;Peptides;phenome;Phenotype;Play;pleiotropism;Population;Population Heterogeneity;Prevalence;programs;protein complex;Public Health;racial disparity;racial population;Research;Research Personnel;Risk;Risk Factors;Role;sex;social health determinants;System;Techniques;Testing;tool;Underrepresented Populations;United States National Institutes of Health;unsupervised clustering;Variant;whole genome;Work

PROJECT_TITLE: Discovery of Immunogenomic Associations with Disease and Differential Risk Across Diverse Populations


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Avoidant/restrictive food intake disorder (ARFID)—which affects 3% of children and adolescents—is a severe mental illness that causes people to eat an insufficient volume or variety of food and puts them at risk for medical and psychological compromise. There is currently no evidence-based treatment, but cognitive- behavioral therapy for ARFID (CBT-AR) is a promising new intervention that reduces food avoidance by targeting (1) the maladaptive thoughts that prevent trying new foods, and (2) hyperactivity of brain regions involved in fear processing. In the current study we will conduct two randomized controlled trials to ensure that CBT-AR engages one or both of these critical targets and that it substantially reduces food avoidance by doing so.

PI_NAMEs: EDDY, KAMRYN T;LAWSON, ELIZABETH AUSTEN (contact);THOMAS, JENNIFER JOANNE

PROJECT_TERMS: active control;Adolescent;Adult;Advocate;Affect;Aftercare;Age;Amygdaloid structure;Anterior;arm;avoidant restrictive food intake disorder;behavior change;Brain region;Central Nervous System;Child;Chronic;cingulate cortex;Clinical;clinical trial analysis;Clinical Trials;Cognitive;Cognitive Therapy;Counseling;Cues;Data;Dependence;Development;dietary supplements;Disease remission;Dose;Eating;Eating Disorders;effectiveness trial;efficacy trial;Evidence based treatment;Exhibits;Food;food avoidance;Fright;Functional Magnetic Resonance Imaging;Hyperactivity;Impairment;Individual;Intervention;Interview;Investigational Therapies;Learning;Malnutrition;Manuals;Measures;Mediating;Medical;Motivation;multidisciplinary;National Institute of Mental Health;neuromechanism;novel;nutrition;Occupational Therapy;Outcome;Patients;Persons;Phase;Pica Disease;pressure;prevent;Prevention;psychologic;psychosocial;Randomized;Randomized, Controlled Trials;Recommendation;response;Risk;Rumination Disorders;severe mental illness;Standardization;Statistical Data Interpretation;telehealth;Testing;Therapeutic Intervention;Thinking;treatment of anxiety disorders;trend;Validation;Work;Youth

PROJECT_TITLE: Cognitive and neural mechanisms of cognitive-behavioral therapy for avoidant/restrictive food intake disorder


NIH_SPENDING_CATS: Cancer

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative The PI3K/Akt signaling is one of most important oncogenic events in human cancers, which regulates many aspects of biological functions including cell proliferation, survival, and metabolism important for cancer initiation and progression. The objectives of this study are to dissect the upstream regulatory mechanisms by which growth factors activate and recruit SETDB1 and E3 ligases TRAF6 to elicit Akt methylation and subsequent K63-linked ubiquitination, to understand how Akt ubiquitination triggers Akt membrane recruitment and activation, and to explore these regulatory mechanisms and its targeting in oncogenic processes. Our study represents a highly innovative and paradigm-shift proposal that will not only open up a new avenue for PI3K/Akt signaling regulation, but also offer new concepts and strategies for cancer targeting.

PI_NAMEs: LIN, HUI-KUAN  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;Automobile Driving;Biochemical;Biological;Biological Process;cancer initiation;Cancer Intervention;cancer therapy;Cell Proliferation;Complex;Development;Dose;druggable target;Event;frontier;Genetic;Goals;Growth Factor;Human;innovation;insight;Insulin-Like Growth Factor I;Knock-in Mouse;Knowledge;Ligase;Link;Malignant Neoplasms;Mediating;Membrane;Metabolism;Methylation;Methyltransferase;Modeling;Modification;mouse model;Mus;novel;Oncogenic;Organoids;Patients;pharmacologic;Phosphorylation;Phosphotransferases;PIK3CG gene;Play;Post-Translational Protein Processing;PRKDC gene;Process;Proteomics;recruit;Regulation;Research;Role;SETDB1 gene;side effect;Signal Pathway;Signal Transduction;small molecule inhibitor;Technology;therapeutic target;TRAF6 gene;Treatment Factor;tumor;tumor progression;tumor xenograft;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Xenograft procedure

PROJECT_TITLE: Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of this project is to develop a revolutionary, new generation of implantable neurodevices that will communicate with, learn from, and teach their human hosts to better treat disease. Current implantable devices are blind to human actions, thoughts and behavior, which limits their effectiveness. State of the art computer techniques that can measure behavior and link them to brain activity will empower patients to teach, control and learn from their devices to improve health and quality of life.

PI_NAMEs: LITT, BRIAN  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Affect;Area;Behavior;blind;Brain;brain computer interface;brain machine interface;Caring;Clinical;cloud based;Communication;computer science;Computers;convolutional neural network;Coupling;Data;deep learning;Devices;Disease;Educational process of instructing;Effectiveness;Electric Stimulation;empowerment;Engineering;Epilepsy;experience;Feeling;Generations;Goals;Health;Human;Implant;implantable device;improved;intelligent algorithm;Intervention;Investigation;Knowledge;learned behavior;Learning;learning algorithm;Life;Link;Machine Learning;Measurement;Measures;Methods;Natural Language Processing;Nervous System Disorder;neural;Neurologic;Neurology;next generation;novel;Office Visits;Patients;Pattern;Peripheral;Physicians;Play;Process;Psychological reinforcement;Quality of life;Role;Sampling;sensor;Spinal Cord;Stream;Techniques;Technology;Therapeutic;Thinking;tool;United States National Institutes of Health;User-Computer Interface;Work

PROJECT_TITLE: Ghost in the Machine: Melding Brain, Computer and Behavior


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative The prevalence and incidence of cardiometabolic diseases are increasing worldwide, contributing to high levels of morbidity and mortality. In this study we investigate pleiotropy and construct polygenic risk scores across cardiometabolic disorders, in diverse ancestry populations. This research will lead to a better understanding of the transferability of polygenic risk scores from discovery to target populations of different ethnicities, inform prevention and diagnostic strategies that could contribute to the development of effective public health policies.

PI_NAMEs: ADEBAMOWO, SALLY NNEOMA (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Adult;Affect;African;African American population;African ancestry;All of Us Research Program;American;Biological;Body mass index;burden of chronic illness;Cardiometabolic Disease;cardiometabolism;Catalogs;causal variant;Cause of Death;clinical risk;Complex;Coronary Arteriosclerosis;Data;Data Set;Databases;Development;diagnostic strategy;Disease;disorder risk;Dyslipidemias;Environmental Risk Factor;ethnic minority population;Ethnic Origin;Etiology;European;European ancestry;Funding;Gene Frequency;Genetic;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;genomic locus;genomic variation;Genomics;health inequalities;Health Policy;Human;Hypertension;Incidence;Individual;insight;Investigation;large datasets;Lead;Link;Linkage Disequilibrium;Mendelian randomization;Minority Groups;Morbidity - disease rate;mortality;National Human Genome Research Institute;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Participant;Pathway interactions;Phenotype;pleiotropism;polygenic risk score;Population;Population Heterogeneity;Population Study;Prevalence;Prevention strategy;programs;Public Health;racial minority population;Reporting;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk variant;Scoring Method;Signal Transduction;Site;statistics;Target Populations;trait;Translating;United States National Institutes of Health;Validation;Variant;Veterans;whole genome

PROJECT_TITLE: Leveraging pleiotropy to develop polygenic risk scores for cardiometabolic diseases