NIH_SPENDING_CATS: Aging;Atherosclerosis;Brain Disorders;Cancer;Cardiovascular;Cerebrovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Rare Diseases;Stroke

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE New targeted drugs to treat chronic myelogenous leukemia (CML) have dramatically decreased death from the cancer, turning it into a chronic illness for which treatment is continued indefinitely. Unfortunately, the most effective of these drugs for leukemia results in an increased risk of heart attack and stroke that takes away the survival advantage of the leukemia treatment. This proposal explores a novel mechanism by which one CML drug promotes inflammation of atherosclerotic plaques (the cause of most heart attacks and strokes), will provide comprehensive training for a physician-scientist, and discoveries made will lead to safer cancer treatment by limiting cardiovascular side effects.

PI_NAMEs: STEPANIAN, ALEC  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acute;Adhesions;Advisory Committees;Affect;Age;American;Anti-Inflammatory Agents;Aorta;aortic arch;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;Bcr-Abl tyrosine kinase;Biology;Blood Platelets;Blood Vessels;cancer survival;cancer therapy;cardioprotection;cardiovascular risk factor;Cardiovascular system;career;Cell Adhesion Molecules;Cell Line;Cell surface;Cessation of life;Chromosomal translocation;Chronic;Chronic Disease;Chronic Myeloid Leukemia;Clinical;Coagulation Process;Coronary artery;cytokine;Data;Development;Disease remission;Endothelial Cells;Event;Exhibits;Flow Cytometry;Future;Generations;Genetic;genetic approach;Goals;High Prevalence;Histology;Human;ICAM1 gene;Imatinib;Immunofluorescence Immunologic;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Inflammation;Inflammatory;inhibitor;Injury;insight;intercellular cell adhesion molecule;intravital microscopy;knock-down;Knockout Mice;leukemia;leukemia treatment;Leukocyte Trafficking;Leukocyte Trafficking Induction;Leukocytes;Life;Malignant Neoplasms;Measures;Mediating;Modeling;Molecular;Molecular Biology;mouse model;Mus;Mutation;Myocardial Infarction;new therapeutic target;NF-kappa B;novel;Nuclear;Outcome;P-Selectin;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Physicians;Plasma;Prevalence;prevent;promoter;Proto-Oncogene Proteins c-abl;Publishing;Quantitative Reverse Transcriptase PCR;Receptor Inhibition;Receptor Signaling;Resistance;Risk;Role;Rupture;Safety;safety assessment;Scientist;Selectins;Serum;side effect;Signal Transduction;Small Interfering RNA;Stroke;stroke event;success;Survivors;survivorship;Testing;Thrombosis;thrombotic;Time;TNF gene;TNFRSF1A gene;Toxic effect;Training;Tumor Necrosis Factor Receptor;Tyrosine Kinase Inhibitor;Umbilical vein;vascular inflammation;Western Blotting

PROJECT_TITLE: Mechanism of Ponatinib induced vascular toxicity


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Microenvironmental factors derived from a tissue niche can regulate the development of local tissue macrophages through specialized signaling pathways. This proposal focuses on determining whether perivascular macrophage (pvMAC) endothelin signaling regulates vascular function in tissue at steady-state and whether increased heme availability in the perivascular niche drives EdnrB expression in pvMACs through the inhibition of transcriptional repressor Bach1.

PI_NAMEs: MOLINA, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adipose tissue;angiogenesis;BACH1 gene;Biological Assay;Biology;blood pressure regulation;Blood Vessels;Blood-Borne Pathogens;Cell Separation;Cell surface;Cells;Clinical;Coculture Techniques;density;Development;Endothelial Cells;Endothelin;Endothelin B Receptor;Endothelin Receptor;Erythrocytes;experimental study;fibrosarcoma;folate-binding protein;G-Protein-Coupled Receptors;gene conservation;Gene Expression Profile;genetic signature;Heme;Hemolysis;Hemolysis Induction;Homeostasis;Hypertension;Immune;Immune response;Immunosuppression;in vivo;inhibitor;insight;Iron;Ischemia;Knockout Mice;Knowledge;Laboratories;Ligands;Location;Macrophage;Modeling;Molecular;mouse model;Mus;Pathologic;Pathologic Processes;Pathway interactions;Perivascular Neoplasm;pharmacologic;Phenotype;Play;Population;preservation;Process;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Source;Structure of parenchyma of lung;Surveys;Testing;Tissues;transcription factor;Transcription Repressor;Translating;tumor;Tumor Promotion;Vascular Permeabilities;Vascular System;Vasoconstrictor Agents;Work

PROJECT_TITLE: Uncovering the function of EdnrB in perivascular macrophages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lupus

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Inappropriate responses to self nucleic acids by immune receptors called Toll-like receptors (TLRs) can lead to autoimmune diseases such as lupus, psoriasis, and rheumatoid arthritis. What goes wrong to enable such responses in certain individuals who develop disease remains unclear. This application focuses on the discovery of new mechanisms that when disrupted promote responses to self nucleic acids by TLRs and drive autoimmune disease.

PI_NAMEs: BARTON, GREGORY M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Alanine;Autoimmune;Autoimmune Diseases;Autoimmunity;base;Biological Process;Cells;Cellular biology;Code;CRISPR screen;Discrimination;Disease;DNA;effective therapy;Endosomes;Extracellular Space;Family;Funding;Genes;genome-wide;Goals;Grant;Health;Human;Immunologic Receptors;improved;in vivo;Individual;Innate Immune System;insight;Knock-in Mouse;Lupus;Lysosomes;Mediating;member;Microbe;Modeling;Molecular;Molecular Chaperones;multidisciplinary;Mus;Mutagenesis;Mutation;nucleic acid delivery;Nucleic Acids;Pathway interactions;Patients;Play;Positioning Attribute;Psoriasis;Psoriatic Arthritis;receptor;Regulation;Research;research study;response;Rheumatoid Arthritis;Risk;RNA;Role;Scanning;Testing;TLR8 gene;Toll-like receptors;trafficking;Variant;Work

PROJECT_TITLE: Regulation of TLR trafficking for proper self versus non-self discrimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-U (02)]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Narrative Autism Spectrum Disorder (ASD) affects approximately 1% of the world’s population with no available mechanism-based therapies. Fragile X Syndrome (FXS) is the leading monogenic cause of ASD, the most common inherited cause of intellectual disability and can serve as a baseline for biological and genetic studies in the development of effective treatments. This conference will bring together leading scientists and clinicians studying FXS and autism-related disorders with the ultimate goal of identifying the molecular, cellular and circuit mechanisms responsible for underlying symptoms and how to best translate this knowledge into clinical trials.

PI_NAMEs: HUBER, KIMBERLY M. (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Academia;Acceleration;Address;Affect;Angelman Syndrome;Area;Atmosphere;autism spectrum disorder;autism symptoms;Basic Science;Behavior;Biochemical Pathway;Biological;Biology;career;career development;Career Mobility;Cell model;Cell Physiology;Cellular Assay;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Collaborations;commune;Communication;Communities;Complex;cost;COVID-19 pandemic;Development;Disease;Education;effective therapy;Evaluation;experience;Faculty;faculty mentor;Feedback;Fertilization;FMR1 gene;Fostering;Fragile X Gene;Fragile X Syndrome;frontier;Future;gene therapy;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;Goals;graduate student;Hereditary Disease;Human;Individual;Industry;Inherited;innovation;insight;Intellectual functioning disability;International;Italy;Knowledge;Location;meetings;model organism;Molecular;Multi-Institutional Clinical Trial;Neurodevelopmental Disorder;Neurons;Neurosciences;new technology;novel strategies;Organoids;Participant;Patients;Policies;Population;Postdoctoral Fellow;posters;pre-clinical;pre-clinical research;Publications;Renaissance;Research;Research Methodology;Research Personnel;Rett Syndrome;Risk;Science;Scientific Advances and Accomplishments;Scientist;single cell sequencing;stem cells;Student Selections;Students;success;symposium;Symptoms;Syndrome;synergism;System;Technology;Therapeutic;therapeutic development;therapeutic target;Time;tool;Training;Translating;Translational Research;translational scientist;Tuberous Sclerosis;United States National Institutes of Health;Variant

PROJECT_TITLE: 2024 Fragile X and Autism-Related Disorders Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: NARRATIVE: Lung cancer is the leading cause of cancer deaths in the world, and while treatment options have improved, there remains a tremendous need for targeted therapies to improve lung cancer survival rates. Our lab has recently identified PRMT5 as a putative modulator of NRF2, an oncogenic transcription factor that is selectively essential in lung cancers, which could serve as a more tractable target for the development of novel therapies. This project will combine biochemical and functional genomic approaches to determine the molecular mechanisms that link NRF2 and PRMT5 and assess its potential as a target for novel cancer targeted therapies.

PI_NAMEs: ESPINOSA DE LOS REYES, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acute;Address;Amino Acids;antagonist;Binding;Biochemical;Biological Assay;Biology;cancer cell;Cancer cell line;Cancer Etiology;cancer subtypes;cancer type;Cessation of life;Chemicals;ChIP-seq;Chromatin;Clinical;Co-Immunoprecipitations;cofactor;Complex;conventional therapy;CRISPR screen;crosslink;Data;Dependence;design;Development;Disease;DNA Binding;drug development;drug discovery;Drug Targeting;Elements;experimental study;Fluorescence-Activated Cell Sorting;Foundations;functional genomics;Future;Genetic;Genetic Transcription;genome-wide;Genomic approach;Germ Lines;Goals;Growth;Health;Human;Hyperactivity;Immunotherapy;improved;In Vitro;inhibitor;Investigation;kinase inhibitor;Knock-out;Knockout Mice;Knowledge;Link;loss of function;loss of function mutation;lung cancer cell;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Modeling;Molecular;mouse model;Mus;mutant;Mutation;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel therapeutics;nuclear factor-erythroid 2;Oncogenic;Organoids;Output;Oxidation-Reduction;Patients;personalized medicine;Phase;Phenotype;Physiological;Prognosis;protein purification;Proteins;reconstitution;recruit;Reporter;Repression;Research;Resistance;Resolution;restraint;screening;small molecule inhibitor;Solid;Structure;Survival Rate;targeted cancer therapy;targeted treatment;Testing;Therapeutic Index;therapeutic target;Toxic effect;transcription factor;transcriptome sequencing;tumor;tumor addiction;tumor growth;Tumor Promotion;tumorigenesis;Up-Regulation

PROJECT_TITLE: Mechanistic studies of the NRF2-Methylosome interaction in lung cancer.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Pediatric

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Language deficits have cascading consequences for educational, vocational, and social outcomes. However, it is unknown how deficits in language influence processing of disfluent speech, which accounts for 6% of children’s input. Therefore, this project examines how monolingual and bilingual children with and without developmental language disorder understand and learn from disfluent speech, with an aim toward extending existing theories and interventions to diverse populations and naturalistic linguistic contexts.

PI_NAMEs: LIBERSKY, EMMA JANE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 5 year old;Adult;Affect;Age;Behavior;Behavioral;bilingualism;Brain;Characteristics;Child;Clinical;Cognition;Comprehension;Disease;Disfluent;Education;English Learner;Ethics;experience;experimental study;Exposure to;Eye;Failure;Filler;Frequencies;gaze;Goals;Human;indexing;innovation;insight;Intervention;Investigation;Knowledge;Language;language comprehension;Language Development;Language Development Disorders;Language Disorders;language impairment;language processing;Learning;Linguistics;Measures;Mentorship;Methodology;natural language;neural;novel;Outcome;Performance;Population;Population Heterogeneity;Positioning Attribute;Process;Production;Proxy;Research;Research Personnel;Role;Sampling;scale up;Science;Shapes;Side;Signal Transduction;skills;social;Social outcome;Spanish/English;Speech;Statistical Data Interpretation;Structure;Testing;theories;Training;Translating;Visual;visual tracking;Vocation;Well in self;word learning;Work

PROJECT_TITLE: Listening to and Learning from Disfluent Speech in Children with and without Developmental Language Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Suicide is the second leading cause of death for youth ages 10-14, and rates of suicidal thoughts and behaviors escalate dramatically across late childhood and into adolescence. Developmental risk for suicide, particularly in late childhood and pre-adolescence, remains very poorly understood, and research has yet to rigorously examine subtypes of youth who experience suicidal thoughts and behaviors during this developmental period using variables across multiple domains of functioning and units of analysis. The proposed research will leverage neurobiological, behavioral, and psychological data from the Adolescent Brain Cognitive Development (ABCD) Study to provide one of the first multimodal investigations of suicide subtypes among youth and associations between subtypes and STBs longitudinally, with potential to reveal a more nuanced, person-centered understanding of suicide and implications for youth suicide risk prediction and intervention.

PI_NAMEs: POLLAK, OLIVIA HAVEMEYER (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;Adopted;Adult;Age;Behavior;Behavioral;Brain;Cause of Death;Child;Child Health;Childhood;cognitive development;Complex;critical developmental period;Data;Data Set;Development;Disease;Disinhibition;epidemiologic data;Exhibits;experience;Failure;Feeling suicidal;Future;Goals;Health;Heterogeneity;Individual;Intervention;Investigation;Life;Literature;longitudinal dataset;Measurement;Measures;Methodology;Modeling;multimodal data;multimodality;National Institute of Mental Health;neural;Neurobiology;neuroimaging;novel;Outcome;Pathway interactions;Patient Self-Report;Pattern;person centered;Persons;Phenotype;Population;Positioning Attribute;preadolescence;Prevalence;Process;prospective;prospective test;psychologic;Psychological Factors;Public Health;recruit;Research;Research Design;Research Priority;Risk;Risk Behaviors;risk prediction;Sample Size;Sampling;Site;stem;Subgroup;suicidal;suicidal adolescent;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptoms;Testing;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Examining subtypes of suicidal youth in the Adolescent Brain Cognitive Development Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diabetes-related chronic inflammation is a significant oral healthcare problem as well as poor craniofacial bone repair that is observed in diabetic patients. This proposal will study how engineered mesenchymal stem cell- derived extracellular vesicles can be utilized to target a specific inflammatory pathway in a controlled manner in diabetic animals. The proposed studies will lead to the development of a hydrogel-based extracellular vesicle delivery system that enhances immunomodulatory activity leading to better bone/tissue repair.

PI_NAMEs: LEUNG, KASEY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Alginates;Animals;Anti-Inflammatory Agents;Area;Binding;Biocompatible Materials;Biology;Biomimetics;bone;bone healing;Bone Regeneration;bone repair;Bone Tissue;Calvaria;career development;Cartilage;Cells;Cellular biology;Chronic;clinical translation;Communities;Complex;Control Groups;controlled release;craniofacial bone;craniofacial tissue;Cues;cytokine;Defect;design;Development;Development Plans;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Dose;efficacy evaluation;Encapsulated;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Equilibrium;Event;experience;Extracellular Matrix;extracellular vesicles;Foundations;Gelatinase A;Generations;Goals;healing;Health;Healthcare;Histology;Hydrogels;Image;Immunohistochemistry;Immunology;immunoregulation;Impairment;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Injury;Institution;interest;Kinetics;Knowledge;Laboratories;laboratory experience;Learning;Macrophage;Mediating;Mediator;Mentorship;Mesenchymal Stem Cells;Metalloproteases;MicroRNAs;miRNA expression profiling;Modeling;Molecular Biology;monomer;Mus;Muscle;Natural regeneration;Nerve;Oral;Oral health;Osteogenesis;overexpression;paracrine;Pathway interactions;Peptide Hydrolases;Peptides;Phase;Process;Property;recruit;regeneration potential;regenerative;Regenerative pathway;repair model;repaired;Research;Research Personnel;Research Training;Resources;Role;Scientist;Site;skills;Specific qualifier value;Specificity;stem cell biology;stem cell exosomes;Stimulus;System;Systemic disease;systemic inflammatory response;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Tissue Engineering;tissue regeneration;tissue repair;Tissues;tool;Tooth Diseases;Training;type I and type II diabetes;Vertebral column;Work;wound;wound healing

PROJECT_TITLE: Endogenous Protease Mediated Delivery of Engineered Immunomodulatory Extracellular Vesicles

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE: We are planning a center called DISCOVER,Development of Investigators Supporting Community Outreach and Value of Engagement in health disparities Research, DISCOVER, to train researchers who are early in their career how to conduct research to reduce health disparities in the areas of cancer, stroke and maternal health. The DISCOVER Center will help researchers engage with community members in Washington DC and share the results of their research.

PI_NAMEs: GRAVES, KRISTI D. (contact);MCKINNEY, CALEB ;ROETT, MICHELLE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Academic Medical Centers;Address;Aging;Area;Asian;Award;Awareness;Black race;cancer health disparity;Capital;career;catalyst;Clinical;Clinical and Translational Science Awards;Clinical Investigator;cohort;Communication;Communities;community academic partnership;community advisory board;community engagement;Community Outreach;community partners;Competence;Comprehensive Cancer Center;Dedications;Development;Discipline of Nursing;District of Columbia;early-career faculty;Educational Curriculum;Elements;Eligibility Determination;Enrollment;Equity;Evaluation;experience;Fostering;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;Hispanic;improved outcome;Infant Health;Information Dissemination;Infrastructure;innovation;Institution;instructor;K-Series Research Career Programs;Knowledge;Latino;Leadership;Life Expectancy;Malignant Neoplasms;Maternal Health;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;next generation;Not Hispanic or Latino;novel strategies;Outcome;peer;peer coaching;Population;population health;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Pregnancy;professor;programs;Race;Reduce health disparities;Research;research and development;Research Methodology;Research Personnel;Research Training;Resources;Schools;skills;social health determinants;Stroke;structural determinants;Students;TNFSF15 gene;Training;Washington;Workforce Development

PROJECT_TITLE: Development of Investigators Supporting Community Outreach and Value of Engagement in health disparities Research (DISCOVER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (J1)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GRAVES, KRISTI D. (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Advocate;Applications Grants;Area;Award;career;career development;career networking;Caregivers;Clinical;cohort;Collaborations;Communication;Communities;community advisory board;community engagement;Community Outreach;design;Development;District of Columbia;Doctor of Philosophy;Ensure;Exercise;experience;Feedback;Fostering;Funding;Funding Opportunities;Health;Health Disparities Research;health disparity;health equity promotion;health plan;Infrastructure;Leadership;Malignant Neoplasms;Maternal Health;meetings;member;Mentors;Mission;Newsletter;organizational structure;Outcome;Patients;Process;Productivity;Qualitative Evaluations;Quantitative Evaluations;Reporting;Research;Research Personnel;Resource Sharing;Resources;Schedule;Stroke;Structure;success;supportive environment;synergism;Training;Training Activity;Update;user-friendly;web site;Work


PI_NAMEs: MCKINNEY, CALEB  (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Advocate;Area;career;Career Mobility;cohort;Collaborations;Communities;community academic partnership;community advisory board;community collaboration;Community Developments;community engagement;community involvement;Community Outreach;community partnership;community planning;Competence;cultural health;Development;Development Plans;Discipline;Disparity;District of Columbia;early-career faculty;Educational workshop;Equity;experience;Fostering;Funding;Future;Goals;Grant;Health;Health Disparities Research;health disparity;Health system;Individual;Information Dissemination;Infrastructure;innovation;interdisciplinary approach;Interdisciplinary Study;interest;Lead;Malignant Neoplasms;Maternal Health;member;Mentors;metropolitan;minority disparity;multidisciplinary;Outcome Assessment;peer coaching;Postdoctoral Fellow;Process;Productivity;programs;Publishing;Request for Applications;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Resources;Rotation;Site;skills;Stroke;Structure;success;synergism;Talents;Training;training opportunity;Writing


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: ROETT, MICHELLE  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;advocacy organizations;Advocate;Affect;African American;Area;Black race;Budgets;cancer health disparity;career;Caring;Clinic;clinical practice;Collaborations;Communication;Communities;community advisory board;community clinic;community collaboration;community engaged approach;community engaged research;community engagement;community organizations;Community Outreach;Community Participation;community partners;community partnership;community-centered;design;Development;dissemination strategy;District of Columbia;early experience;Education;Educational workshop;Equity;Event;evidence base;experience;Feedback;Funding;Goals;Health;Health Disparities Research;health disparity;health equity;health inequalities;health outcome disparity;Health Policy;Healthcare Systems;Hispanic;Home;implementation science;Individual;Information Dissemination;interest;investigator training;Latino;Lead;Learning;Linguistics;Malignant Neoplasms;Maternal Health;meetings;member;Mentors;Methods;Newsletter;novel strategies;Outcome;outreach;patient navigation;Patients;Personal Satisfaction;Persons;Pilot Projects;Policies;Policy Maker;Population;Productivity;programs;Provider;racial minority;Recommendation;Reduce health disparities;Research;Research Methodology;Research Personnel;Resources;Rotation;Strategic Planning;Stroke;Structure;Training;training opportunity;Translating;Update;Visual;Washington;web site;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: SOCIETY OF BEHAVIORAL MEDICINE

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) The Society of Behavioral Medicine’s 45th Annual Meeting & Scientific Sessions, to be held March 13-16, 2024, in Philadelphia, PA, will bring together 1,800 of the nation’s leading behavioral scientists, clinicians, educators, and policymakers to exchange new research on improving health through behavior change, in particular by moving behavioral science upstream. Through a broad range of scientific presentations, discussions, and skill-building workshops, the meeting will facilitate the exchange of the latest population‐level, clinic‐based, and experimental research on the prevention and treatment of the leading causes of morbidity and mortality, with the goals of improving health behaviors, reducing the burden of chronic disease, improving health inequities, lowering healthcare costs, and bettering our nation’s health.

PI_NAMEs: FUEMMELER, BERNARD F (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Affect;Area;Behavior;behavior change;behavior influence;Behavioral;Behavioral Medicine;Behavioral Sciences;Biometry;burden of chronic illness;Cardiovascular Diseases;Cessation of life;Chronic Disease;Chronic lung disease;Clinic;clinical care;Collaborations;Communication;Communities;community partners;Complex;Decision Making;Dedications;Development;Diabetes Mellitus;digital;digital health;Disabled Persons;Discipline;Discipline of Nursing;Discrimination;Disease;Disease Management;disorder prevention;Education;Educational workshop;effective intervention;Epidemiology;ethnic minority;Event;evidence base;Exercise;Exhibits;experimental study;Family;Funding;gender minority;Goals;Government Agencies;Guidelines;Health;Health behavior;Health Care Costs;health equity;health inequalities;Health Promotion;Healthcare;improved;Individual;Industry;industry involvement;industry partner;innovation;Institution;Institutional Racism;Intervention;Knowledge;Laws;Leadership;Malignant Neoplasms;Medical;Medicine;meetings;member;Mentors;mid-career faculty;Minority Groups;Mission;model design;Morbidity - disease rate;mortality;National Cancer Institute;National Heart, Lung, and Blood Institute;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Pathway interactions;Patients;Personal Satisfaction;Persons;Philadelphia;Play;Policies;Policy Maker;Population;posters;prevent;Prevention;Psychology;psychosocial;Public Health;public health relevance;racial minority;Reduce health disparities;Research;Research Design;Research Personnel;Resources;Respiratory Disease;Risk Factors;Role;Science;Scientific Societies;Scientist;sedentary lifestyle;skills;Skin;Societies;Strategic vision;Stress;success;Theoretical model;theories;therapy design;Tobacco use;Training;Translating;United States;Voice;Work

PROJECT_TITLE: Society of Behavioral Medicine 2024 Annual Meeting & Scientific Sessions

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

PHR: NARRATIVE Severe obesity (BMI≥40kg/m2; ~>100 lbs overweight) is associated with myriad chronic cardiometabolic disease, sleep disorders, and cancer, and with increasing disparities disproportionately impacting Hispanic/Latino populations. We propose to fill critical gaps in the translational pipeline in a study unprecedented in size and ancestral diversity, shedding light on inherent (e.g., genetic) and mutable (e.g., transcriptomic, metabolomic) factors that impact severe obesity and downstream disease, identifying clinical significance of SevO susceptibility in HL individuals and novel targets for early prevention and pharmaceutical intervention. By addressing severe obesity in a population historically under-represented in translational studies, our work contributes to the NIH’s mission to promote disease prevention and treatment in historically marginalized populations.

PI_NAMEs: BELOW, JENNIFER ;GORDON-LARSEN, PENNY  (contact);NORTH, KARI E.

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Accounting;Address;Adult;biobank;Body mass index;Body System;Cardiometabolic Disease;cardiometabolism;cell type;Central America;Central obesity;Chronic;Clinical;Clinical Research;clinically significant;Complex;Coronary heart disease;Data;Data Analyses;Disease;disorder prevention;Disparity;Electronic Health Record;Ensure;epidemiology study;Exclusion Criteria;experience;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;Genome;genome wide association study;Genomics;Heterogeneity;high risk population;Hispanic;Hypertension;Individual;insight;Intervention;Joints;Kidney Diseases;Knowledge;Latino;Latino Population;Life Expectancy;Light;Link;Literature;Malignant Neoplasms;Maps;marginalized population;Measures;Mendelian randomization;Metabolic Pathway;metabolomics;Methodology;Methods;Mission;Modeling;Molecular;Morbid Obesity;multiple omics;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity risk;Outcome;Overweight;Pathogenicity;Pathway Analysis;Pathway interactions;Pattern;personalized approach;Pharmacologic Substance;phenome;polygenic risk score;Population;Population Heterogeneity;Predisposition;Prevalence;Prevention;prospective;Quantitative Trait Loci;Research;Research Project Grants;research study;Risk;Risk Factors;Signal Transduction;Sleep Disorders;South America;statistics;tool;trait;Transcript;transcriptome sequencing;transcriptomics;translational genomics;translational pipeline;translational study;United States National Institutes of Health;Validation;Variant;Weight;Whole Blood;Woman;Work

PROJECT_TITLE: Leveraging metabolic pathways and gene expression data to propel understanding of severe obesity in a vulnerable and understudied population

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) is a highly aggressive and understudied lung cancer subtype characterized by enhanced metastasis and poor patient survival. The therapeutic landscape for the treatment of SCLC is bleak, with treatment options limited to predominantly chemotherapeutics, to which resistance rapidly emerges. This proposal seeks to understand an as-of-yet undescribed metabolic dysregulation phenotype which can then be therapeutically leveraged to treat SCLC.

PI_NAMEs: BARBIER, ROBERTO HUGO (contact)

PROJECT_TERMS: Address;Adverse event;Anions;Biochemical Pathway;biological adaptation to stress;Biological Assay;Cancer cell line;cancer subtypes;CD147 antigen;Cell Death;Cell Death Induction;Cells;Collaborations;combat;Combined Modality Therapy;CRISPR/Cas technology;cytotoxic;Data;Dependence;deprivation;Disease;Disseminated Malignant Neoplasm;effectiveness evaluation;efficacy evaluation;efficacy testing;Energy Metabolism;Energy Metabolism Pathway;experimental study;Family;FDA approved;Flow Cytometry;gene repression;Genetic;Genetic Transcription;genome-wide;Genus Hippocampus;Glucose;Glutamine;Glutathione;Goals;Heterogeneity;Homeostasis;Human;Immunocompetent;Impairment;Implant;improved;In Vitro;in vivo;inhibitor;Injections;Investigation;kinase inhibitor;knock-down;Knock-out;Knowledge;Lipid Peroxidation;loss of function;Lung Adenocarcinoma;lung cancer cell;Malignant neoplasm of lung;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolic profile;Metabolic stress;metabolomics;Mitochondria;Modality;Molecular Chaperones;mouse model;Nature;Neoplasm Metastasis;novel;novel therapeutics;Nude Mice;overexpression;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;patient prognosis;Patients;pharmacologic;Pharmacotherapy;Phenotype;Phosphotransferases;pyruvate carrier;Radiation;Reactive Oxygen Species;Regulation;Research;Resistance;Resistance development;Role;small cell lung carcinoma;small hairpin RNA;stable isotope;Stable Isotope Labeling;synergism;System;targeted treatment;Therapeutic;therapeutic development;therapy resistant;tumor;tumor heterogeneity;Validation;whole genome;Work

PROJECT_TITLE: ABL kinase inhibition sensitizes SCLC to dysregulation of metabolic pathways leading to cell death

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Electronic Nicotine Delivery Systems;Lung;Prevention;Pulmonary Fibrosis;Rare Diseases;Tobacco

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Narratives Our proposed studies for development of novel collagen targeted MRI contrast agent will have a strong impact on lung fibrosis patient care and clinical research by distinguishing IPF patients who are experiencing rapid progression from those who are stable. It fills in major medical gaps, including guiding treatment strategies designed to reverse fibrosis, monitoring treatment of high-risk patients with fibrosis, and preclinical drug discovery to reduce collagen expression. It will allow us to understand the molecular mechanism of fibrosis initiation and progression, and key factors that contribute to lung fibrosis, including public health issues related to e-smoking and COPD.

PI_NAMEs: YANG, JENNY J. (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Affinity;Air Pollution;Animal Model;Animals;Binding;biophysical techniques;Biopsy;Bleomycin;Cause of Death;Child;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Collagen;comorbidity;Complex;Contrast Media;density;Deposition;design;Detection;detection sensitivity;Development;Diagnosis;Diagnostic Procedure;Disease;Disease Progression;Disease regression;dosage;drug discovery;Drug Monitoring;Early Diagnosis;Electronic cigarette;electronic cigarette use;Ensure;Exhibits;experience;Extracellular Matrix;Fibrosis;Goals;Half-Life;heart motion;High Resolution Computed Tomography;high risk;Histologic;Human;idiopathic pulmonary fibrosis;Image;imaging capabilities;imaging modality;improved;in vivo;in vivo imaging;Interobserver Variability;Interstitial Lung Diseases;Ionizing radiation;Lung;Lung Diseases;lung imaging;lung injury;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Medical;metal poisoning;Metals;Methodology;Methods;Molecular;molecular marker;Molecular Target;Monitor;mouse model;nintedanib;Noise;non-invasive imaging;novel;Operative Surgical Procedures;overexpression;Patient Care;patient population;Patients;Pattern;Phase;physical impairment;Physiological;Positron-Emission Tomography;pre-clinical;pre-Investigational New Drug meeting;Pregnant Women;Property;Proteins;Public Health;Pulmonary Fibrosis;Radiation;Radio;Radiology Specialty;Relaxation;Reporting;Resistance;respiratory;Safety;Sensitivity and Specificity;Severities;Signal Transduction;Site;Smoking;soft tissue;Specificity;Staging;Tissues;Tobacco smoking behavior;translational potential;Translations;treatment response;treatment strategy;Universities;Usual Interstitial Pneumonia;Virus Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Development of Protein MRI Contrast Agent for Precision Imaging Lung Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (J2)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Atypical lateralization of auditory processing is a biomarker associated with language impairment deficits in autism spectrum disorder (ASD). The proposed project is relevant to public health because it will investigate the impact of MeCP2 loss, a mouse model of a neurodegenerative form of ASD called Rett syndrome, on the neural circuits underlying lateralized vocalization processing functions that are shared between humans and mice. The long-term goal of this proposal is to establish a pipeline to study and rescue functional communication deficits in mouse models of ASD, which will in turn identify molecular pathways and critical development time periods as targets for the development of human therapeutic interventions.

PI_NAMEs: OVIEDO, HYSELL VIVIANA (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: 3-Dimensional;Affect;Auditory;Auditory area;auditory processing;autism spectrum disorder;autism symptoms;Behavior;Biological Markers;Brain;cell type;Cerebral Dominance;Child;Code;Communication;Communication impairment;Complex;Contralateral;critical developmental period;critical period;Data;Development;disability;Electrophysiology (science);endophenotype;Equilibrium;Etiology;excitatory neuron;Frequencies;Functional disorder;Genes;Goals;Human;Image;In Vitro;in vivo;inhibitory neuron;innovation;insight;Interneurons;Knowledge;Laboratories;language impairment;language processing;Left;Link;loss of function;loss of function mutation;Maps;Methyl-CpG-Binding Protein 2;model of autism spectrum disorder;Molecular;Molecular Target;Motor;mouse model;Mus;Mutation;Nerve Degeneration;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;Neurophysiology - biologic function;novel;optogenetics;Parvalbumins;Pathologic;Pathway interactions;Pattern;Population;prevent;Property;Public Health;Regulation;Research;response;Rett Syndrome;risk variant;Sensory;sensory input;social communication;sound;Speech Perception;speech processing;Synapses;System;Therapeutic Intervention;Time;Translating;vocalization;Wild Type Mouse;Work

PROJECT_TITLE: Disruption of lateralized auditory cortical function in a mouse model of Rett Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (47)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Vocal prosody inflections like voice pitch are essential for expressing agreement or disagreement, to correct, to signal novel information, or to indicate between-the-lines meaning. Listeners who wear cochlear implants do not perceive vocal prosody as well as listeners with normal hearing due to device limitations, and struggle with communication in ways that cannot be verified using percent-correct scores for the words alone. The goal of the proposed research is to examine CI listeners’ perception of prosody relative to normal hearing listeners and to study what acoustic cues are perceived by each of these listener groups when determining which words are emphasized in speech.

PI_NAMEs: WHEELER, HARLEY JAMES (contact)

PROJECT_TERMS: Acoustics;Address;Affect;Agreement;analog;Audiology;Auditory;behavior measurement;Canis familiaris;Clinical;Cochlear Implants;Communication;Cues;Data;design;Devices;Disparity;Environment;Evaluation;experimental study;Goals;Grain;Grant;Hearing;hearing impairment;Impairment;improved;Individual;Institution;Instruction;Intention;interdisciplinary collaboration;Knowledge;Link;Masks;Measures;Mentorship;Methods;National Institute on Deafness and Other Communication Disorders;Noise;normal hearing;novel;Patient Self-Report;Patients;Perception;Performance;Persons;Play;Psychoacoustics;Psychophysics;Quality of life;Recording of previous events;Reporting;Research;response;Role;Science;Sensory;Series;Signal Transduction;skills;Slide;social;Speech;speech in noise;Speech Intelligibility;Speech Perception;speech recognition;standard measure;Statistical Data Interpretation;Stimulus;Stress;Testing;Training;Training Programs;transmission process;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: Prosody perception in cochlear implant listeners

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Overdose deaths have been on the rise over the past decade, a trend that has been exacerbated by the current global pandemic, with over 93,000 overdose deaths in 2020. This proposal will investigate cocaine- dependent signaling related to Reelin, a glycoprotein newly described as a marker of cocaine-responsive medium spiny neurons. This work will provide novel insight into the molecular basis of substance abuse disorders that may form the basis of desperately-needed targeted treatment strategies.

PI_NAMEs: BRIDA, KASEY LYNN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Action Potentials;addiction;Adult;adverse outcome;Alzheimer's Disease;Architecture;Attenuated;Award;Behavior;behavior influence;Behavioral;behavioral response;Biological Assay;Brain;Brain Diseases;brain tissue;cell cortex;cell motility;Cells;Cerebellum;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine related behaviors;cocaine reward;cocaine self-administration;cocaine sensitization;Cocaine use disorder;conditioned place preference;Corpus striatum structure;cost;COVID-19 pandemic;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Critical Thinking;Cytoskeleton;Data;Data Set;Death Rate;Development;Dimensions;Disease;Dissociation;Dopamine;Dopamine Receptor;Dorsal;Drug Exposure;drug induced behavior;drug of abuse;drug reward;drug seeking behavior;Economic Burden;Electrophysiology (science);Engineering;experience;experimental study;FDA approved;Fluorescent in Situ Hybridization;gene induction;genetic manipulation;Glycoproteins;Health;Health Care Costs;Hippocampus;Human;Impairment;in vivo;Induced Neurons;Injections;innovation;insight;interdisciplinary approach;Intravenous;Investigation;knock-down;Learning;Link;lissencephaly;Mediating;Membrane;Messenger RNA;Methamphetamine;Modeling;Molecular;mortality;Motivation;Mutation;N-Methylaspartate;Nervous System Disorder;Neurobiology;neuronal excitability;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;Output;Overdose;overdose death;overexpression;pandemic disease;patch clamp;Pathogenesis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Physical Dependence;Physicians;Physiological;Physiology;Play;preference;prevent;programs;Proteins;Publishing;Rattus;reelin protein;Regulation;response;Rewards;RNA;Role;Schizophrenia;Scientist;Self Administration;sex;Signal Transduction;single molecule;single nucleus RNA-sequencing;skills;Slice;Stimulus;Substance abuse problem;Substance Use Disorder;success;Sucrose;Synapses;targeted treatment;Techniques;Testing;Therapeutic;Time;treatment strategy;trend;Ventral Tegmental Area;Work

PROJECT_TITLE: Role of Reelin protein in the cellular and behavioral response to drugs of abuse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Debilitating cognitive deficits are common in many neurodevelopmental disorders, such as those associated with copy number variants of Tbx1, a gene encoded in a nested 1.5 Mb region of 22q11.2. Using mouse models, we will determine the role of Tbx1 in myelination and its effect on cognitive speed. These studies will advance our understanding of the mechanisms underlying cognition and promote novel approaches to clinical interventions for neurodevelopmental disorders.

PI_NAMEs: WELLS, ANNE MARIE (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 22q11.2;4-Hydroxy-Tamoxifen;Adult;adult neurogenesis;Affect;Attention;autism spectrum disorder;Behavioral;Brain;Capital;Cell Proliferation;Cerebrum;ChIP-seq;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive process;cognitive task;Complex;Copy Number Polymorphism;critical developmental period;Data;design;Development;diagnostic biomarker;DiGeorge Syndrome;Dimensions;dysmyelination;Exhibits;experimental study;Fiber;flexibility;FOXG1B gene;Generations;Genes;Genetic;Goals;Heterozygote;high risk;Human;Impaired cognition;Impairment;In Vitro;in vivo;Intellectual functioning disability;Intervention;Knowledge;Learning;Letters;Link;Live Birth;Measures;Memory;memory acquisition;Mental disorders;Messenger RNA;Molecular;mouse model;multidisciplinary;Mus;Myelin;myelination;National Institute of Mental Health;Neonatal;neonatal period;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Nomenclature;novel;novel strategies;oligodendrocyte progenitor;Oligodendroglia;Patients;Phenotype;Physicians;Postembryonic;postembryonic stem cell;postnatal period;precision medicine;precursor cell;Process;Production;Proteins;Puberty;Public Health;Regulation;Research;Research Domain Criteria;Role;Schizophrenia;Scientist;spatial memory;Speed;stem cell proliferation;stem cells;Tamoxifen;Testing;Text;therapy development;Training;Transcript;transcription factor;Work

PROJECT_TITLE: Identifying a critical developmental period for cognitive speed in a mouse model for neurodevelopmental disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Human diseases caused by parasitic flatworms afflict millions of people worldwide and cause significant healthcare burdens in many countries. The current clinical therapy relies on a single drug (praziquantel, PZQ) for which the parasitic target was only recently discovered – a transient receptor potential ion channel activated by PZQ (TRPMPZQ). My proposal builds from our discovery of TRPMPZQ to develop new and improved therapies for neglected tropical diseases caused by tapeworms (cestodes) and blood flukes (schistosomes).

PI_NAMEs: ROHR, CLAUDIA M (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affect;Amino Acids;Anthelmintics;Antiparasitic Agents;Binding;Bioinformatics;Biology;career;Cell Culture Techniques;Cell Line;Cestoda;Cestode Infections;Classification;Clinical;Communities;Country;Data;Diphyllobothriasis;Disease;dosage;Drug Design;Drug Screening;Drug Targeting;Drug usage;druggable target;Enrollment;experience;Family;Fasciola hepatica;Fluorescence;gene product;Generations;genetic manipulation;Genus Diphyllobothrium;global health;Goals;healthcare burden;high-throughput drug screening;human disease;improved;In Vitro;Infection;insight;Ion Channel;Laboratories;Life Cycle Stages;Ligands;Lung;Maps;Mentors;Methods;Molecular;Molecular Cloning;Molecular Target;Morbidity - disease rate;neglect;neglected tropical diseases;novel;novel therapeutics;Orthologous Gene;paralogous gene;Paralysed;Parasites;Parasitic Diseases;Parasitology;Permeability;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiology;Platyhelminths;Praziquantel;Property;Protocols documentation;Public Health;receptor;Reporter;Reproducibility;Resolution;RNA Interference;Role;Schistosoma;Schistosoma mansoni;Schistosomatidae;Schistosomiasis;sensor;skills;Sparganosis;Sparganum;Spirometra;stable cell line;symposium;Techniques;Testing;Therapeutic;therapeutic target;tool;Training;Transmembrane Domain;Trematoda;TRP channel;Variant;voltage;Work;World Health Organization

PROJECT_TITLE: Functional interrogation of parasitic flatworm TRPM channels to identify novel anthelmintics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Inflammation-induced anorexia is a complication of numerous common diseases such as cancer and inflammatory bowel disease, and can lead to malnutrition and increase morbidity. Despite decades of study, the neural circuits and cell types responsible for driving this form of feeding suppression remain unclear. Using IL- 1β to model inflammation-induced anorexia, coupled with genetic approaches and in vivo calcium imaging, we aim to dissect how peripheral inflammation is communicated through peripheral sensory neurons to the central nervous system, which may ultimately lead to the discovery of therapeutic targets for this condition.

PI_NAMEs: HAYES, NIKOLAS  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;acute symptom;Afferent Neurons;Anorexia;Appetite Depressants;Area;Attenuated;Autoimmune Diseases;Automobile Driving;awake;Behavioral;Bilateral;Brain;Calcium;Cell Nucleus;Cell secretion;cell type;Cells;Central Nervous System;Cholecystokinin;Chronic Disease;chronic inflammatory disease;common symptom;Communication;Complex;Complication;computer program;Coupled;cytokine;Data;designer receptors exclusively activated by designer drugs;Desire for food;Dinoprostone;Disease;Dissection;Dose;Eating;Educational workshop;experimental study;Faculty;feeding;Fellowship;Fiber;FLP recombinase;Foundations;gastrointestinal;Genetic;genetic approach;Goals;Guide RNA;Homeostasis;Hormones;Hunger;Hypothalamic structure;Image;Immune;Immunology;in vivo;in vivo calcium imaging;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Infusion procedures;insight;Interleukin-1 beta;Ketorolac;Knock-out;Knowledge;Literature;Malignant Neoplasms;Malnutrition;Mediating;Mentorship;Metabolism;Microsurgery;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Motor Neurons;Mus;neural;neural circuit;Neural Inhibition;neuroimmunology;Neurons;Nodose Ganglion;novel;novel strategies;Nutrient;Nutritional;Operative Surgical Procedures;Peripheral;Photometry;Population;Positioning Attribute;Postdoctoral Fellow;postoperative recovery;Process;programs;Prostaglandins;psychologic;receptor;response;Role;Satiation;Signal Transduction;skills;Structure of nucleus infundibularis hypothalami;Systemic disease;Techniques;Testing;Therapeutic;therapeutic target;tool;Training;Universities;Vagotomy;Vagus nerve structure;Work

PROJECT_TITLE: Dissecting the Mechanisms Underlying Inflammation Induced Anorexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Infant Mortality;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This project employs innovative single-cell transcriptomics, conditional gene-targeting, genetic rescue, and maternal intervention approaches to systematically address the mechanisms of neural tube defects in mutant mouse models. It may provide a basis for future translational applications to prevent neural tube defects in humans.

PI_NAMEs: ZHOU, CHENGJI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Animal Model;Apical;Back;beta catenin;Bladder;Brain;Cell Polarity;Cells;Cessation of life;Child;Complex;Congenital Abnormality;constriction;convergent extension;Craniorachischises;Defect;design;Developmental Process;disability;Disease;Dorsal;early pregnancy;Ectoderm Cell;Exhibits;F-Actin;Face;Folic Acid;folic acid supplementation;Future;Gene Modified;gene regulatory network;Gene Targeting;Genes;Genetic;genetic risk factor;genetic testing;Goals;Human;Impairment;innovation;insight;Intervention;Intestines;Lifelong disability;Morbidity - disease rate;Mus;mutant;mutant mouse model;Mutant Strains Mice;Neonatal Mortality;Neural Fold;neural initiation;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;Neuroectoderm;neuroepithelium;neuromechanism;Newborn Infant;novel;novel strategies;Paraplegia;Pathway interactions;pharmacologic;planar cell polarity;Play;Prevalence;prevent;Prevention;programs;Publishing;receptor;Research;Resistance;Risk;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Spinal;Spinal Cord;Spinal Dysraphism;Spinal meninges;Structure;Supplementation;Surface;Surface Ectoderm;Targeted Research;Testing;transcription factor;transcriptome sequencing;transcriptomics;Translating;translational applications;Vertebral column;WNT Family Gene;WNT Signaling Pathway;Work

PROJECT_TITLE: Integrated Wnt signaling and maternal intervention of neural tube defects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE There is increasing recognition of a subpopulation of cognitively resilient individuals that live to advanced age with intact cognitive function despite the presence of amyloid-beta plaque and tau tangle pathology. This proposal aims to investigate the role of Neuritin-1 as a molecular mediator of cognitive resilience to Alzheimer’s disease. Our studies will further the understanding of mechanisms underlying resilience that may provide insights into therapeutics designed to prevent or delay dementia.

PI_NAMEs: PUGH, DERIAN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;asymptomatic Alzheimer's disease;Autopsy;Behavior;Biology;Brain;Brain region;Cessation of life;Clinical;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive performance;Computer Analysis;Confocal Microscopy;Coupled;Dementia;Dendritic Spines;density;Dependovirus;design;Development;DLG4 gene;Elderly;Electrophysiology (science);Exhibits;Functional disorder;Genes;Glutamate Receptor;Goals;Hippocampus;Human;human old age (65+);Impaired cognition;Individual;Induced Neurons;insight;Knowledge;Link;Maintenance;Mass Spectrum Analysis;Medial;Mediating;Mediator;Medical;Memory;Microscopy;mild cognitive impairment;Molecular;morphometry;mouse model;Multiregional Analyses;Mus;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuronal Injury;Neurons;neuropathology;neuroprotection;normal aging;Older Population;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Persons;pre-clinical;Predisposition;Prefrontal Cortex;preservation;prevent;Proteins;Proteome;Proteomics;Publishing;Recombinants;religious order study;Reporting;resilience;Resolution;Risk;Role;Sampling;Senile Plaques;Staging;Synapses;synaptic function;System;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;Tissues;United States;Validation;Work;β-amyloid burden

PROJECT_TITLE: Defining the Neuroprotective Mechanisms of Neuritin-1 in Cognitive Resilience to Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Women's Health Research

PHR: Project Narrative Antihormone therapy resistance and metastasis accounts for the majority of estrogen receptor positive (ER+) breast cancer related deaths in the United States, but the role cancer-associated fibroblasts (CAFs) play in the resistance mechanism is poorly understood. This proposal aims to better understand the mechanism of how antihormone therapy (tamoxifen) activation of the G-protein coupled estrogen receptor (GPER) on CAFs aids in the progression of ER+ breast cancer. The success of the proposed research will offer insight into GPER as a potential driver of antihormone resistance in ER+ breast cancer and elucidate if GPER is a viable marker of therapy reistance.

PI_NAMEs: FERTAL, SHELBY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Academia;Acceleration;Address;Age;Agonist;antagonist;Architecture;Atomic Force Microscopy;Behavior;behavior in vitro;Biochemical;Biophysics;Biopsy;Breast;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;career;career development;Cell Line;Cells;Cessation of life;clinically relevant;cohort;Collagen;Complement;CRISPR/Cas technology;Cues;cytokine;Data;density;Deposition;Disease Progression;Disease Resistance;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Female;Fiber;Fibroblasts;Firefly Luciferases;Foundations;Goals;GPER gene;Growth;hormonal signals;hormone resistance;hormone therapy;human disease;Image;Immunofluorescence Immunologic;improved outcome;In Vitro;in vivo;insight;Intention;Invaded;knock-down;Knock-out;Knowledge;Length;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Matrix Metalloproteinases;Mediating;Mentorship;Modeling;Monitor;mortality;Mouse Mammary Tumor Virus;Multivariate Analysis;Mus;Neoplasm Metastasis;neoplastic cell;novel;Ovariectomy;Patient-Focused Outcomes;Patients;Play;polyoma middle tumor antigen;preclinical study;prevent;Primary Neoplasm;professor;Proliferating;Protein-Lysine 6-Oxidase;receptor expression;Receptor Signaling;Recurrence;Research;Research Training;Resistance;resistance mechanism;Risk;Role;Signal Transduction;Solid;Solid Neoplasm;standard of care;success;synergism;Tamoxifen;Testing;theories;therapy development;therapy outcome;therapy resistant;Tissues;Transplantation;tumor;Tumor Cell Invasion;Tumor Cell Migration;tumor microenvironment;tumor progression;United States;Universities;Vocational Guidance;Western Blotting;Width;Wisconsin;Woman;Work

PROJECT_TITLE: Investigating the role of G-protein coupled estrogen receptor expression on cancer associated fibroblasts in therapy resistant ER+ breast cancer progression


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Epithelial cells are essential for organismal development and homeostasis and require precise coordination of polarity information to properly form and function. A wealth of studies have uncovered proteins required for cell polarity, however, little is known about how these core protein complexes 'break symmetry' to initiate and define asymmetric domains within cell collectives. The proposed work will shed light on fundamental cellular processes essential for the formation and maintenance of epithelial tissues and will help better understand the normal and disease states of epithelial cells.

PI_NAMEs: DEVITT, CAITLIN C (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Ablation;Actins;Apical;Automobile Driving;beta catenin;Caenorhabditis elegans;Cell Adhesion Molecules;cell assembly;Cell Physiology;Cell Polarity;Cell-Cell Adhesion;Cells;Complex;Congenital Abnormality;Core Protein;Cues;Cytoplasm;Cytoskeleton;Development;Disease;Drosophila genus;E-Cadherin;Embryo;embryo cell;Embryonic Development;Ensure;Environment;Epithelial Cells;Epithelium;Event;experimental study;Face;Future;Goals;Homeostasis;Image;in vivo;Individual;Intestines;Lasers;Light;Link;macromolecular assembly;Maintenance;Maps;Mechanics;Membrane;Modeling;Molecular;molecular assembly/self assembly;molecular asymmetry;Molecular Probes;molecular scale;Monitor;Movement;Oncogenic;Oocytes;Organism;Pattern;polarized cell;prevent;Primordium;Process;programs;Property;protein complex;protein E;protein oligomer;Proteins;Reproducibility;Role;Saccharomycetales;segregation;Simple Epithelium;Stochastic Processes;Structure;Surface;System;Testing;Time;Tissues;tool;Tube;tumorigenesis;Work;zygote

PROJECT_TITLE: Symmetry Breaking in Cell Assemblies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE GABAergic inhibitory synapses mediate inhibitory synaptic function in the brain, which is crucial for learning, memory, and cognition. Inhibitory synapses are critical for regulating neuronal excitability and mediating synaptic plasticity. Delineating the molecular mechanisms that control inhibitory synaptic plasticity is vital for our understanding of synaptic function and could provide critical insight into numerous neurological disorders.

PI_NAMEs: WOLFE, SARAH E (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: A kinase anchoring protein;Acute;Behavioral;Brain;Brain Diseases;Calcineurin;calcineurin phosphatase;Calcium;Cell Nucleus;Cells;Chemosensitization;Cognition;Confocal Microscopy;Coupling;Data;density;Disease;Electrophysiology (science);Gene Expression;gene repression;Genetic Transcription;gephyrin;Glutamates;Hippocampus;Human;improved;in vivo;Inhibitory Synapse;insight;knock-down;Knowledge;Learning;Lighting;live cell imaging;Long-Term Potentiation;Mediating;Memory;MicroRNAs;Microscopy;Molecular;mouse model;Nervous System Disorder;neuronal excitability;Neurons;novel;nuclear factors of activated T-cells;Nuclear Translocation;Output;Pathology;Pathway interactions;Phosphoric Monoester Hydrolases;postsynaptic;presynaptic;Process;Protein Biosynthesis;protein transport;Proteins;receptor;Repression;Rodent;Role;Scaffolding Protein;Sensory;Signal Transduction;Site;Slice;Structure;Synapses;synaptic function;synaptic inhibition;Synaptic plasticity;Synaptic Transmission;Testing;three dimensional structure;trafficking;transcription factor;Transcriptional Regulation;Translational Repression;Translations;Work

PROJECT_TITLE: Mechanisms of transcriptional regulation to control inhibitory synaptic plasticity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Goal-directed behaviors maximize rewards in changing environments, and abnormalities in goal-directed behavior are a functionally impairing feature of a range of neuropsychiatric diseases. Accumulating evidence suggests a role for dorsomedial striatal GABAergic parvalbumin-positive fast-spiking interneurons (PV+ FSIs) and somatostatin-positive low-threshold spiking interneurons (SST+ LTSIs) in value-based goal-directed behavior; however, this has not been directly tested. I aim to record and causally manipulate PV+ FSIs and SST+ LTSIs in mice performing a value-based goal-directed behavioral task to elucidate the role of striatal interneurons in striatal function and goal-directed behavior.

PI_NAMEs: ILIAKIS, EVAN ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acceleration;Anterior;Area;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;comparative;Complement;Corpus striatum structure;cost;Data;Decision Making;Dendrites;discrimination task;Environment;Event;evidence base;Exhibits;expectation;experimental study;Feedback;Fiber;Functional impairment;Goals;Halorhodopsins;Head;Impairment;Individual;interest;Interneurons;Learning;lens;Mediating;Midbrain structure;Motor;Movement;Mus;neuronal cell body;Neurons;neuropsychiatric disorder;novel;Opsin;optogenetics;Outcome;Output;Parvalbumins;Pattern;Photometry;Photons;Play;Population;Positioning Attribute;Prefrontal Cortex;Probability;process optimization;Recording of previous events;recruit;Refractive Indices;response;Rewards;Role;Sensory;sensory discrimination;Shapes;Signal Transduction;Somatostatin;Testing;Thalamic structure;translational potential;Update

PROJECT_TITLE: Investigating the Role of GABAergic Interneurons in the Dorsomedial Striatum in Goal-Directed Behavior


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Nutrition;Osteoporosis;Physical Activity;Prevention

ORG_CITY: SAN DIEGO

ORG_DEPT: NUTRITION

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This proposal is to support early career and diverse investigators to attend and defray conference costs for the only meeting focused on prevention of musculoskeletal disorders throughout the lifespan.

PI_NAMEs: WEAVER, CONNIE MARIE (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Age-Related Osteoporosis;Aging;Basic Science;bone;Bone Diseases;bone health;bone mass;California;career;career development;Clinical Research;cost;Diet;dietary;Effectiveness;Environment;Event;evidence base;Exercise;Exposure to;Fatality rate;Foundations;Funding;Grant;Growth;Health;healthy aging;International;life span;Life Style;meetings;Mentorship;Mobility decline;Muscle;muscle form;Musculoskeletal;Musculoskeletal Diseases;Myopathy;nutrition;Nutritional;Osteoporosis;Osteoporosis prevention;Outcome;pandemic disease;pharmacologic;Physical activity;Prevention;Publishing;Recommendation;Request for Applications;Research;Research Personnel;Risk;Running;Safety;sarcopenia;Science;Scientist;Secure;Series;side effect;skeletal;social;Specialist;symposium;Time;Training;Translations;Travel;Work

PROJECT_TITLE: International Symposium on Nutritional Aspects of Musculoskeletal Health

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

PHR: While sleep is typically defined by slow waves of activity extending across broad neuronal populations, recent work reveals a separate encoding in microcircuit spike patterns. This proposal investigates the hypothesis that each individual neuron’s spiking patterns represent a localized scale of sleep. Fast (<100 ms) local states are detected in single neurons and shown to explain key aspects of natural behavior.

PI_NAMEs: SCHNEIDER, AIDAN  (contact)

PROJECT_TITLE: The Sleep Signature: A Disentangled State in Each Neuron


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Loss of synapses is the strongest neuropathological correlate of cognitive decline in Alzheimer’s disease (AD) patients, yet the mechanisms that drive specific synapses to be eliminated and others spared are not fully understood. The goal of this proposal is to (1) elucidate the molecular mechanisms that regulate synaptic exposure of phosphatidylserine, a molecule that has been previously shown to drive synapse loss in AD, (2) determine how these pathways influence glial synaptic uptake and in vivo synaptic function, and (3) measure activity of these pathways within AD patient brain tissue. Completion of this proposal has the potential to identify novel therapeutic targets regulating synapse loss in AD enabling the development of drugs that can potentially stymie and reverse cognitive decline in AD patients.

PI_NAMEs: SHROFF, KUNAL  (contact)

PROJECT_TERMS: abeta oligomer;Ablation;activity marker;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Astrocytes;Behavioral;behavioral phenotyping;Biological Assay;Biological Models;Biology;Brain;brain tissue;career;Cell membrane;Cell Surface Receptors;Cellular Stress;Cerebral Ischemia;Clinical;Coculture Techniques;Code;CRISPR interference;Data Set;density;Diagnosis;differential expression;disease model;drug development;Electrophysiology (science);Excision;extracellular;Functional disorder;functional genomics;Future;Genes;Genetic;genetic manipulation;Genome;Goals;IL11RA gene;Impaired cognition;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Interleukin-11;Interleukin-6;Interleukins;Investigation;JAK1 gene;JAK2 gene;Link;Macrophage-1 Antigen;Measures;Mediating;Mentorship;Modeling;Molecular;mouse model;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologist;Neurons;neuropathology;neurotransmitter release;new therapeutic target;novel;Pathway interactions;Patients;Phagocytes;pharmacologic;phosphatidylserine receptor;Phosphatidylserines;Phospholipids;phosphoproteomics;Physicians;Positioning Attribute;prevent;Prevention;protein biomarkers;Proteins;Proteomics;receptor;Research;Role;Scientist;screening;Signal Pathway;Signal Transduction;Stains;STAT1 gene;STAT3 gene;Stat3 Signaling Pathway;Synapses;synaptic function;Synaptosomes;Tauopathies;Techniques;Technology;Testing;therapeutic target;training opportunity;uptake;validation studies;Work

PROJECT_TITLE: Molecular mechanisms of synapse loss in Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ORG_CITY: EL PASO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE – OVERALL The University of Texas at El Paso (UTEP) Center for Investigator Training and Community Engagement in Transdisciplinary Minority Health Disparities Research proposes to implement a specialized community engaged research-training program for equitable academic and community partnerships to participate in the design and implementation of collaborative research projects aimed at eliminating health disparities in the Paso del Norte region. Our Center of Excellence (COE) builds on a strong foundation of demonstrated commitment for community engaged scholarship, a strong record of intellectual community engaged capacity and robust support from community-based organizations. The conceptual framework of the Center of Excellence includes a syndemics model to implement an interdisciplinary and transdisciplinary approach that leverages long existing institutional community-engaged culture and networks to train investigators and community partners on health research and intervention development.

PI_NAMEs: DUARTE-GARDEA, MARIA O. (contact);MANGADU, THENRAL ;SIAS, JERI J

PROJECT_TERMS: Address;Affect;Cardiovascular Diseases;career;Collaborations;Communities;community academic partnership;community center;community engaged research;community engagement;Community Health;community intervention;community organizations;community partners;community partnership;culturally appropriate intervention;design;Development;Diabetes Mellitus;Discipline;Economics;Educational workshop;Equity;evidence base;Face;faculty mentor;Foundations;Funding;Future;Goals;Grant;Health;Health Disparities Research;health disparity;Health Policy;health training;Healthcare;Heart Diseases;higher education;Hispanic;Hispanic Populations;Home;Hypertension;improved;Income;innovation;Institution;interdisciplinary approach;Intervention;investigator training;Knowledge;Language;Leadership;Left;Malignant Neoplasms;Medically Underserved Area;member;Mental Health;Mentors;Mexico;Minority;minority engagement;minority health;minority health disparity;Modeling;Morbidity - disease rate;National Institute on Minority Health and Health Disparities;novel;Obesity;Overweight;Pilot Projects;Population;practical application;Program Evaluation;programs;repository;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Scholarship;Science;social health determinants;Structure;success;syndemic;Teacher Professional Development;Texas;therapy development;Training;Training Programs;Translating;Translational Research;underserved area;United States Health Resources and Services Administration;Universities;Work;Writing

PROJECT_TITLE: UTEP Center for Investigator Training and Community Engagement in Transdisciplinary Minority Health Disparities Research


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DUARTE-GARDEA, MARIA O. (contact)

PROJECT_TERMS: academic program;Achievement;Address;Adopted;Advocate;behavior change;career development;Centers of Research Excellence;Chronic Disease;Collaborations;Communication;Communities;community engaged approach;community engaged research;community engagement;Community Networks;community organizations;community partners;Data Collection;Decision Making;Development;Discipline;Educational process of instructing;Ensure;Evaluation;experience;Feedback;Future;Goals;Grant;Guidelines;Health;Health Disparities Research;health disparity;Hispanic;Hispanic Populations;Human Resources;improved;infrastructure development;Institution;Intervention;investigator training;Leadership;Minority;Minority Groups;minority health;minority health disparity;Mission;Monitor;National Institute on Minority Health and Health Disparities;Nature;next generation;Organizational Efficiency;organizational structure;Outcome;Policies;Population;Principal Investigator;Process;Program Evaluation;programs;Progress Reports;Regulation;repository;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Scholarship;Scientific Evaluation;Scientist;Structure;Students;Sum;Support System;System;Training;Training Activity;underserved minority;United States Health Resources and Services Administration;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


PI_NAMEs: MANGADU, THENRAL  (contact)

PROJECT_TERMS: Address;career;Case Study;college;Communities;community engaged research;community engagement;Community Health;Community Networks;community partnership;Complex;Development;Discipline;Disease;Disparity;Education;Educational workshop;empowerment;Environment;Evaluation;experience;Face;Fostering;Funding;Goals;Grant;Guidelines;Health;health care availability;Health Disparities Research;health disparity;health equity;health inequalities;healthspan;Hispanic;hispanic community;innovation;Institution;interdisciplinary collaboration;Intervention;investigator training;Knowledge;Location;mentoring community;Mentors;Mentorship;Minority;minority communities;minority engagement;Minority Groups;minority health disparity;Minority Health Research;Modeling;Needs Assessment;next generation;Outcome;Pilot Projects;Policies;programs;Publications;Research;research and development;Research Design;research in practice;Research Personnel;research study;Research Training;resilience;Resource Allocation;Resources;Risk;Risk Factors;Scholarship;Science;Scientist;Series;Shapes;social health determinants;Socioeconomic Factors;syndemic;Teacher Professional Development;Texas;translational engagement;United States National Institutes of Health;Universities;Update;Workforce Development

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SIAS, JERI J (contact)

PROJECT_TERMS: Address;Area;bilingualism;Border Community;Charge;Communication;Communications Media;Communities;community academic partnership;community based participatory research;community building;Community Developments;community engagement;Community Integration;community involvement;community organizations;community partnership;community research;Concha;Development;doctoral student;Educational process of instructing;Educational workshop;Ensure;Equity;Ethics;expectation;Faculty;Foundations;Goals;Health;health communication;Health Disparities Research;health disparity;health equity;health inequalities;health science research;Hispanic;Human Resources;investigator training;Knowledge;Language;Leadership;Linguistics;member;Mentorship;Mexico;minority health disparity;Modeling;National Institute on Minority Health and Health Disparities;Paper;Pilot Projects;Policies;Press Releases;Principal Investigator;Process;programs;Public Policy;Publications;Radio;Recording of previous events;Research;Research Personnel;Research Priority;Scholarship;skill acquisition;skills;social health determinants;social media;Solid;Spanish;Spanish/English;symposium;syndemic;System;theories;Translating;Translational Research;Universities;Voice;Work;Writing

PROJECT_TITLE: Community Engagement and Dissemination Core


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Previous efforts at developing a computational framework to predict arrhythmia risk based on a drug’s chemical structure have not been able to predict the risk associated with binding the hERG channel and prolonging the cardiac action potential. Atomistic modeling of state-specific drug interactions with the hERG, hNaV1.5 and hCaV1.2 channels is a promising solution. The proposed experiments will allow us to classify the arrhythmogenic risk associated with common drugs, and aid in the screening of new compounds for proarrhythmic risk.

PI_NAMEs: ROUEN, KYLE C (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;Affinity;Anti-Arrhythmia Agents;Antibiotics;Antihistamines;Arrhythmia;Bayesian learning;Binding;Calcium;Calcium Channel;Cardiac;Cardiac Electrophysiologic Techniques;career;Cells;channel blockers;Chemical Structure;Classification;clinical risk;Communication;computational pipelines;computer framework;Computer Models;Data;design;Development;Docking;drug development;Drug Interactions;Electrophysiology (science);Ethers;Exclusion;experience;experimental study;Female;Genes;Gonadal Steroid Hormones;Heart Block;heart rhythm;Human;improved;in silico;In Vitro;in vitro Assay;Individual;Investigation;Ion Channel;Ions;kinetic model;Kinetics;Knowledge;large scale simulation;Life;Ligand Binding;Ligands;Long QT Syndrome;Machine Learning;Maps;Measurement;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;novel therapeutics;Pharmaceutical Preparations;Pharmacology;Phase;Physiology;preference;Publishing;Research;Risk;risk prediction;Role;Scientist;screening;simulation;Site;skills;small molecule;Sodium;Sodium Channel;Structural Models;Structure;sudden cardiac death;Techniques;Testing;Therapeutic;Time;Tissues;Torsades de Pointes;Training;Ventricular Arrhythmia;voltage;voltage clamp;Voltage-Gated Potassium Channel;Work

PROJECT_TITLE: Investigation of state-specific drug binding to cardiac ion channels to reveals mechanisms of arrhythmogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Diabetes;Heart Disease;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Diabetic cardiomyopathies (T2DCM) are a leading cause of death nationwide, and understanding metabolic interplay in the heart is crucial for the development of new therapies. This proposal aims to use human induced pluripotent stem cells (iPSCs) to derive cardiovascular cell types for in vitro modeling of T2DCM. Two- dimensional monolayer and three-dimensional engineered heart tissues will be used to identify cell-autonomous mechanisms and metabolic interplay, followed by proteomic interrogation to elucidate cardioprotective targets.

PI_NAMEs: CAUDAL, ARIANNE  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Acceleration;Affect;Age;Atherosclerosis;Autopsy;Binding;Binding Proteins;biobank;Biological;Biomedical Research;Blood Vessels;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardioprotection;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular Models;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Line;Cell Physiology;cell type;Cells;Cessation of life;Clinical Trials;Communities;Complex;Conditioned Culture Media;Coupled;design;Development;diabetic;diabetic cardiomyopathy;diabetic patient;directed differentiation;Disease;disease phenotype;Endothelial Cells;endothelial stem cell;ethnic diversity;Excretory function;fascinate;Fibroblasts;Functional disorder;Genetic;Glucose;glucose uptake;glycemic control;Heart;Heart failure;Hospitalization;Human;human induced pluripotent stem cells;Hypertension;in vitro Model;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitor;innovation;insight;Isotopes;Kidney;knock-down;Knock-out;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;metabolomics;migration;Mitochondria;Modeling;Molecular;monolayer;mortality;Myocardial;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oxygen Consumption;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient retention;Patients;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Population;Preclinical Testing;prevent;Proliferating;Protective Agents;protective effect;Proteins;Proteolysis;Proteomics;Protocols documentation;Public Health;Research;Research Personnel;Resolution;Respiration;Sampling;sex;Signal Transduction;Sodium;stem cell model;symporter;System;Systems Biology;Therapeutic;tissue culture;Tissues;tool;Training;two-dimensional;Type 2 diabetic;Validation;Ventricular Remodeling

PROJECT_TITLE: Understanding Metabolic Interplay in a Human iPSC Model of Diabetic Cardiomyopathy


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Myocardial infarction causes tissue fibrosis, organ dysfunction, and heart failure, which leads to 19% of all deaths in the United States. This study will investigate the molecular mechanisms that drive cardiac fibroblasts to deposit excessive scar tissue after myocardial infarction. The results of this study will identify novel targets for therapeutic development to reduce cardiac fibrosis and improve cardiac function after myocardial infarction.

PI_NAMEs: LU, JOHN MING (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;Animal Model;Architecture;Atrial Fibrillation;Automobile Driving;Biological Assay;Blood flow;Cardiac;Cardiovascular system;Cessation of life;Cicatrix;Clinical;Clinical Skills;Collagen;Computer Models;Core Facility;Coronary artery;coronary fibrosis;Data Set;Deposition;Development;Disease;Engineering;Ensure;Environment;Equus caballus;experience;Extracellular Matrix;Fellowship;Fibroblasts;Fibrosis;Finite Element Analysis;frontier;Functional disorder;Future;Genetic;Geometry;Goals;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart function;Heterogeneity;Histologic;Histology;Hydrogels;hypertensive heart disease;Image;improved;In Vitro;in vitro testing;in vivo;Infarction;Infrastructure;innovation;insight;Knowledge;Laboratories;Laws;Location;Mechanics;mechanotransduction;Medicine;Mentors;Mentorship;Meta-Analysis;Methods;Molecular;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;Myocardium;Necrosis;new therapeutic target;Normal tissue morphology;Organ;Pathologic;Pathway interactions;Patients;pharmacologic;Physicians;prevent;profibrotic fibroblast;Research;Research Personnel;Research Training;Role;Scientist;single-cell RNA sequencing;Stains;Stress;Stretching;success;Techniques;Testing;therapeutic development;Thinness;Tissue Stains;Tissues;Training;Training Activity;transcriptomics;United States;Universities;Variant;Work

PROJECT_TITLE: Defining the role of mechanotransduction pathways in activating cardiac fibroblasts to cause fibrosis after myocardial infarction.


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Down Syndrome;Genetics;Heart Disease;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Prevention;Rare Diseases

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Congenital heart defects (CHD) are the most common and severe structural birth defects. One type of severe CHD is the atrioventricular septal defect (AVSD), which is rare in the general population but much more common in the Down Syndrome population. We will study AVSD and other types of CHD in children with Down Syndrome to understand the possible genetic modifiers of CHD in Down Syndrome.

PI_NAMEs: FELDMAN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Accounting;Adult;Affect;Arrhythmia;Atrial Heart Septal Defects;atrioventricular septal defect;Blood flow;Candidate Disease Gene;cardiogenesis;Child;Chromosome 2;Chromosome 21;Chromosome 3;Clinical;cohort;comorbidity;Congenital Heart Defects;de novo mutation;Defect;dosage;Down's Syndrome;Emotional;Endocarditis;Event;Exclusion;Fetal Monitoring;Financial Hardship;General Population;Genes;Genetic;genetic analysis;genetic architecture;Genetic Counseling;Genetic Nondisjunction;Genetic study;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide analysis;Goals;Heart;heart function;Hospitalization;Hospitals;Individual;individualized medicine;Infant;Infant Mortality;Inherited;interest;Intervention;Life;Live Birth;loss of function;Masks;Meiosis;Mitral Valve;Mutation;Nucleotides;Odds Ratio;Operative Surgical Procedures;Parents;Pathogenesis;Pathway interactions;Phenotype;polygenic risk score;Population;Postoperative Care;Prevention;Proteins;rare variant;Research;Risk;Risk Factors;risk variant;Role;Sampling;Single Nucleotide Polymorphism;Stroke;Structural Congenital Anomalies;Structural defect;targeted sequencing;Testing;Tricuspid valve structure;Variant;Ventricular Septal Defects;whole genome

PROJECT_TITLE: Rare variants associated with AVSD in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Our qualitative observations that the RNA-binding protein PUM1 is phosphorylated and partitions into condensates in a cell-cycle dependent manner, suggests that PUM1 condensates are dynamically regulated. By characterizing the impact of phosphorylation on PUM1 condensate dynamics during the cell cycle, we aim to establish a fundamental understanding of how biomolecular condensates are precisely regulated so this knowledge may be applied to mitigate pathological aggregate formation in the context of disease.

PI_NAMEs: NNADI, CHIDINMA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Affinity;analysis pipeline;Behavior;Binding;Biological Assay;Cell Cycle;Cell Physiology;Cells;Confocal Microscopy;CRISPR/Cas technology;Cytoplasm;Disease;DNA Damage;Electrophoresis;Equilibrium;Event;Exhibits;Gene Expression;Genetic Transcription;HCT116 Cells;Immunoprecipitation;In Vitro;Individual;inorganic phosphate;Knock-out;Knowledge;Link;Liquid substance;live cell imaging;macromolecule;Mass Spectrum Analysis;Measurable;Measures;Mediating;Membrane;Methods;mimetics;Mitosis;Mitotic;Molecular;mutant;Mutate;nucleic acid binding protein;Pathologic;Phase;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physical condensation;Physiological;Post-Translational Protein Processing;Post-Translational Regulation;posttranscriptional;Process;Property;protein aggregation;protein function;Proteins;quantitative imaging;Recombinants;Regulation;Research;RNA;RNA-Binding Proteins;Role;Site;System;Techniques;Transcription Repressor;Ubiquitination;Untranslated RNA;Variant;Work

PROJECT_TITLE: Post-translational regulation of NORAD-induced Pumilio phase separation


ADMINISTERING_IC: CE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Firearms are involved in about 80% of homicides and half of suicides among teenagers 12 to 19 years old in the United States, resulting in significant injuries, medical cost, and years of potential life lost and related public health burden in our society. It is critical to advance our understanding of the population-level impact of youth specific health policies, particularly bullying policies and firearm policies on reducing youth gun violence and death. The overall goal of our proposal is to improve the evidence base for youth firearm prevention by conducting a comprehensive multilevel evaluation with rigorous use of causal inference methods to assess the confluence of state-level bullying policies and firearm policies on youth gun carrying and firearm-related fatality.

PI_NAMEs: XUAN, ZIMING  (contact)

PROJECT_TITLE: RFA-CE-23-006, The Confluence of State Bullying Policies and Firearm Policies in Reducing Youth Gun Carrying and Fatality


ED_INST_TYPE: SCHOOLS OF NURSING

PHR: PROJECT NARRATIVE The PROTECT human trafficking prevention program takes an innovative and comprehensive public health approach to violence prevention among adolescents. The proposed project will evaluate the PROTECT program, inform program development to reduce youth human trafficking, and improve our understanding of how to leverage a public health approach to violence prevention. Further, this project will illuminate how the socio- structural conditions which operate as risk factors for human trafficking are also risk factors for other forms of violence, informing the development of cross-cutting violence prevention.

PI_NAMEs: MCCAULEY, ERIN J (contact)

PROJECT_TITLE: CE-23-003 - Taking A Public Health Perspective on Human Trafficking: An Evaluation of the PROTECT Prevention Program


ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative With the rising rates of gun violence, there is an urgency to develop innovative interventions that can effectively engage high-risk adults to prevent future firearm-related violence, injury, and death. Violently injured adults (25- 44 years) are at the highest risk for future firearm-related violence, which is why hospitals have become vital locations for violence prevention initiatives. This project will develop an innovative hospital-based brief violence intervention using virtual reality and conduct a rigorous randomized control trial to evaluate its effectiveness for preventing retaliatory firearm-related violence, injury, and mortality among violently injured adults.

PI_NAMEs: THOMSON, NICHOLAS DAVID (contact)

PROJECT_TITLE: RFA-CE-23-006, A Virtual Reality Brief Violence Intervention: Preventing gun violence among violently injured adults


ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study will test the effectiveness of a comprehensive training strategy for the implementation of a universal pediatric-focused firearm injury prevention initiative. Findings will help to establish best practices for delivering firearm injury prevention screening and counseling within the pediatric trauma center. Importantly, this research has the potential to impact clinical care, prevent firearm-related injury and death, and significantly contribute to implementation science.

PI_NAMEs: HOOPS, KATHERINE  (contact)

PROJECT_TITLE: RFA-CE-23-006, Pediatric Trauma Centers RE-AIM at Gun Safety


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project narrative: This study provides a rigorous and impartial evaluation of the potential impact of state alcohol-related firearm laws on firearm-related homicide, suicide and unintentional deaths using content analysis of state statutes, machine learning techniques, and casual inference methods. Additional analyses will investigate whether these laws may have impacts on the incidence of intimate partner homicide. Results from this study will provide robust evidence to assess the potential import of these approaches to reducing the burden of firearm-related deaths in the U.S. without unduly burdening the large number of gun owners who are unlikely to harm themselves or others.

PI_NAMEs: MACINKO, JAMES  (contact);SILVER, DIANA R

PROJECT_TITLE: RFA-CE-23-006, Do state alcohol-related firearm laws reduce mortality? A multicomponent impact evaluation


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative We use natural language processing to analyze data generated from the statewide implementation of an anonymous reporting system to characterize the types of tips reported, what factors influence tip submissions, and whether training influences tip behavior. Findings will inform reporting system prevention efforts.

PI_NAMEs: HEINZE, JUSTIN EDWARD (contact);THULIN, ELYSE JOAN

PROJECT_TITLE: RFA-CE-23-006 - Rigorous examination of anonymous reporting system data to prevent youth suicide and firearm violence: an applied natural language approach