NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Agitation is one of the most common and unmanageable neuropsychiatric symptoms among persons with dementia, affecting 45-83% of this ever-growing population. Pharmacological treatment of agitation often has adverse side effects, and time-constrained caregivers cannot reasonably be expected to monitor the patients and take continuous note of the environment to identify precipitants of agitation. The research and training for this Mentored Quantitative Research Development Award will be centered on identifying digital behavioral markers both during and preceding agitation, identifying environmental precipitants of agitation, and building risk prediction models of agitation using data collected from patients with later-stage dementia and their living environment.

PI_NAMEs: AU-YEUNG, WAN-TAI  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: actigraphy;Address;Affect;Aggressive behavior;Aging;aging and technology;Agitation;Alzheimer's Disease;analytical method;Area;Assisted Living Facilities;Award;barometric pressure;Beds;Behavior;Behavior assessment;Behavior monitoring;Behavioral;burnout;care providers;career;Caregiver Burden;caregiver strain;Caregivers;Clinical;Clinical Research;Controlled Environment;Cues;Data;deep learning;Dementia;dementia care;detection method;Development;Devices;Diagnosis;digital;Early Diagnosis;Early identification;Early Intervention;Educational workshop;Effectiveness;Environment;Environmental Risk Factor;Ethics;Event;experience;Family Caregiver;Formal caregiver;Goals;Health care facility;Home;Human;Humidity;improved;informal care;informal caregiver;Intervention;intervention cost;Label;Light;Long-Term Care;Machine Learning;Measures;memory care;Mental Health;Mentors;Methods;model building;Monitor;motion sensor;Motor Activity;multimodality;neuropsychiatric symptom;Noise;novel;Nursing Records;older adult;Oregon;Participant;Patient Monitoring;Patients;Pattern;Persons;pharmacologic;Pharmacological Treatment;Physical aggression;physical conditioning;poor sleep;Population;pressure;Prevention strategy;Questionnaires;Research;research and development;Research Project Grants;research study;residence;Residential Treatment;Resources;risk prediction model;sensor;side effect;skills;sleep quality;standard of care;Stress;Symptoms;Techniques;Technology;Temperature;Time;Time Series Analysis;Training;verbal;wearable device;Work;Wrist

PROJECT_TITLE: Agitation in Alzheimer's Disease: Identification and Prediction Using Digital Behavioral Markers and Indoor Environmental Factors

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE Leukemia is the most common pediatric cancer and its incidence has increased dramatically in the last 30 years, especially among LatinX. This trend clearly illustrates that environmental factors play a role in the etiology of the disease. To continue and expand research on childhood leukemia and the environment, we plan to support and enrich the infrastructure of four existing environmental epidemiologic studies of childhood leukemia in ethnically- diverse populations of California, Guatemala, Costa Rica and Mexico, and engage public and health professional communities about childhood leukemia prevention.

PI_NAMEs: METAYER, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Affect;Asian;Awareness;bilingualism;Birth Weight;Breast Feeding;built environment;California;carcinogenicity;case control;Case/Control Studies;Chemical Exposure;Chemicals;Child;Childhood;Childhood Leukemia;Collaborations;Communities;community engagement;Costa Rica;Costa Rican;Country;Data;data archive;data sharing;data sharing networks;Data Sources;Databases;design;Developed Countries;Development;Diet;dietary;Disease;disorder risk;Disparity;Education;Education and Outreach;Educational workshop;electronic book;Enrollment;Environment;Environmental Epidemiology;Environmental Health;Environmental Risk Factor;epidemiology study;Equipment and supply inventories;ethnic diversity;Ethnic Population;Etiology;Exposure to;FAIR principles;Funding;Genetic;genetic risk factor;Goals;Guatemala;Health;health organization;Health Professional;Hispanic;Immune;Immune response;improved;Incidence;Individual;Infrastructure;Institution;International;interoperability;Investigation;Latin America;Latin American;Latinx;Latinx population;leukemia;Link;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;medical specialties;Mexican;Mexico;Multimedia;Myelogenous;National Institute of Environmental Health Sciences;Neighborhoods;Outcome;Outcome Study;outreach;Population;Population Heterogeneity;Population Study;prenatal;Prevention;Procedures;process improvement;Prognosis;public database;Public Health;Publications;R24;racial population;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;Role;Seminal;social;social factors;Socioeconomic Status;Source;stressor;Survivors;survivorship;System;Translational Research;trend;Tumor Biology;United States;Vitamins;Vulnerable Populations;webinar

PROJECT_TITLE: Support For Infrastructure of Childhood Leukemia Environmental Research


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Boulder

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed award for research infrastructure at the University of Colorado Population Center will support population science that contributes important insights of relevance to public health. Central research topics include variation in health across sociodemographic groups, reproductive health, links between genetics or the environment and population health, and migration. Findings from research supported by this award inform public health policies and programs.

PI_NAMEs: MENKEN, JANE A (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Acceleration;Address;Age;Agreement;Area;Arts;Award;Behavioral Sciences;Censuses;Cessation of life;cohort;college;Colorado;Communities;Complex;Data;data centers;Data Set;Data Sources;Dedications;Demography;design;Development;Discipline;Educational workshop;Environment;Evolution;experience;Faculty;flexibility;Foundations;frontier;Funding;Future;gang;Generations;Genetic;graduate school;graduate student;Grant;hazard;Health;Health behavior;health disparity;Health Policy;Health system;Healthcare;Home;Honduras;indexing;Infrastructure;innovation;insight;Institution;Investigation;Investments;Leadership;Life;Link;Measures;Medical;member;Mentors;Methodology;Methods;migration;Mission;mortality;National Institute of Child Health and Human Development;Obesity;Outcome;Planet Earth;Population;Population Distributions;Population Dynamics;population health;Population Sciences;Postdoctoral Fellow;Preparation;Productivity;programs;Public Health;Records;Reproductive Health;Research;Research Infrastructure;Research Personnel;Research Support;response;Risk;Scholarship;Science;Scientist;senior faculty;Series;Shapes;Signal Transduction;sociodemographic group;Structure;success;symposium;Time;Universities;Variant;Woman;working group;Writing;Youth


PROJECT_TERMS: Acceleration;Address;Administrative Personnel;Area;Award;Behavioral Sciences;Budgets;Colorado;Communication;Communities;Complex;cost;Dedications;design;Development;Educational workshop;Expenditure;Faculty;flexibility;Funding;Funding Agency;Future;graduate school;Grant;Growth;High Performance Computing;Hour;Human Resources;human subject;Infrastructure;innovation;Investments;Location;member;Mentors;Mission;Modeling;National Institute of Child Health and Human Development;Newsletter;Pathway interactions;Population;Population Dynamics;Population Research;Population Sciences;Positioning Attribute;Preparation;Productivity;programs;Reporting;Research;Research Activity;Research Assistant;research data dissemination;Research Infrastructure;Research Personnel;Resources;response;Savings;Series;Services;social media;Specialist;Structure;success;symposium;Time;undergraduate student;Universities;Vertebral column;Wages;web site;Work;working group;Writing

PROJECT_TITLE: University of Colorado Population Center


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: BOARDMAN, JASON D (contact)

PROJECT_TERMS: Acceleration;Address;Area;cohort;Collaborations;Colorado;Communities;Complex;cost effective;Cost Savings;Creativeness;design;Development;Educational workshop;Ensure;Environment;Faculty;falls;Feedback;Foundations;Fund Raising;Funding;Future;Grant;Growth;Infrastructure;innovation;Interdisciplinary Study;interest;International;Investments;lectures;Mentors;Mission;Names;National Institute of Child Health and Human Development;peer;Population;Population Dynamics;Population Sciences;Positioning Attribute;Productivity;programs;Recommendation;Recording of previous events;Research;Research Infrastructure;Research Personnel;Resources;response;Savings;Series;Source;success;symposium;Thinking;training opportunity;Travel;Universities;Wages;Work;working group;Writing


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Serious Mental Illness;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: Project Narrative The goal of this investigation is to examine the influence of feedback timing on learning and brain activity in individuals with moderate to severe traumatic brain injury (TBI), with and without clinical depression. A paired associate verbal learning task will be used to evaluate whether differential neural circuitry, and related dysfunctional changes underlie impairments in learning from immediate in comparison with delayed feedback. We will also quantify the link between standardized neuropsychological measures and beneficial effects of learning through immediate and delayed feedback in our participants as knowing the association between standardized measures and feedback type (immediate vs. delayed) will allow clinicians to identify individuals who are more likely to benefit from a particular feedback type during learning.

PI_NAMEs: DOBRYAKOVA, EKATERINA  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Affect;Area;Brain;brain circuitry;Brain Injuries;Caregiver Burden;Clinical;clinical practice;clinically significant;Cognition;Cognitive;cognitive process;Collaborations;comorbidity;Data;Depressed mood;depressive symptoms;design;Development;Diagnostic;Disadvantaged;Dissociation;Educational process of instructing;Effectiveness;Environment;executive function;Exhibits;experience;experimental study;Feedback;Fostering;functional independence;Functional Magnetic Resonance Imaging;Funding;Goals;Health Care Costs;Heart;Impairment;improved;Individual;innovation;Inpatients;Intervention;Interview;Investigation;Knowledge;knowledge base;Learning;Lentiform nucleus structure;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Major Depressive Disorder;Measures;Memory;Mental Depression;Mission;National Institute of Neurological Disorders and Stroke;Nervous System;neural circuit;neuromechanism;Neuropsychology;novel;Outpatients;Parkinson Disease;Participant;Pathway interactions;Patients;Performance;Persons;Phase;Population;Prevalence;Probability;Process;Protocols documentation;Publishing;Qualifying;Quality of life;Recording of previous events;recruit;Rehabilitation Outcome;rehabilitation strategy;Rehabilitation therapy;Research;Standardization;standardize measure;Structure;Testing;Translating;Traumatic Brain Injury;Verbal Learning

PROJECT_TITLE: MRI Markers of Feedback Timing during Learning in Individuals with TBI with and without Clinical Depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Musculoskeletal diseases, which affect more than half of the United States population age 18 and over and nearly three-quarters age 65 and over, are among the most debilitating nonfatal health conditions. The causes of these diseases remain poorly understood, and there is a need for better therapies. The UCSF Musculoskeletal Training Program prepares scientists and physicians for a lifetime of scholarly pursuits that lead to in-depth understanding and improved care for patients with MSK diseases.

PI_NAMEs: ALLISTON, TAMARA N;FIELDS, AARON J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Musculoskeletal;Training Programs

PROJECT_TITLE: UCSF Musculoskeletal Training Program


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project will use functional neuroimaging techniques and computational modeling to investigate how arousal states and attention independently and interactively influence basic visual responses in humans. Results will provide invaluable information in our understanding of how attention and arousal alter neuronal communication, shaping how we see. By advancing our understanding of such brain functions, results from this proposal could further our understanding of the cortical and subcortical function of people with abnormal arousal levels (e.g., attention deficit hyperactivity disorder, general anxiety disorder), with potential applications down the road in guiding the diagnoses and treatment of disorders that involve atypical attention and arousal levels.

PI_NAMEs: PAN, JASMINE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: alertness;Animals;Anxiety Disorders;Arousal;Attention;Attention deficit hyperactivity disorder;attentional modulation;Behavior;Behavioral;Brain;Cognitive;cognitive process;Communication;Computer Models;Contrast Sensitivity;Coupled;Decision Making;Diagnosis;Disease;Electrophysiology (science);Environment;extrastriate visual cortex;Functional Magnetic Resonance Imaging;Goals;Human;Individual;insight;Measures;Memory;Methodology;Methods;Modeling;neural;neuroimaging;Neurons;novel;Perception;Persons;Play;Procedures;Process;Property;Psychophysics;Research;response;Role;Shapes;Stimulus;Techniques;Testing;Variant;Vision;Visual;Visual Cortex;visual processing;Visual System;Work

PROJECT_TITLE: How Does Attention and Arousal Interact to Modulate Vision?


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE The earliest cells involved in the immune response to a bacterial infection are the phagocytic cells responsible for internalize, kill bacteria and generate inflammatory signals that coordinate the subsequent immune responses. Recently, we determined that phagocytic cells respond to a sugar that is abundant in the bacterial cell wall and is released when bacteria are degraded and killed. This proposal aims to determine how this bacterial-derived sugar alters the metabolism of phagocytic immune cells and controls the level of inflammation that develops during a bacterial infection in order to better design therapeutics to treat bacterial infections.

PI_NAMEs: WOLF, ANDREA JEAN (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Affect;Amino Acids;Antigen Presentation;Bacillus;Bacteria;Bacterial Infections;Binding;Bone Marrow;CASP1 gene;Cell Wall;Cells;Cellular Structures;Complex;crosslink;cytokine;Cytosol;Dendritic Cells;design;Dissociation;Enzymes;experimental study;Exposure to;Family;Glycolysis;Glycolysis Inhibition;Gram-Positive Bacteria;Gram-Positive Bacterial Infections;hexokinase;Hexokinase 2;Host Defense;IL18 gene;Immune;Immune Evasion;Immune response;Immunologic Receptors;Immunologic Surveillance;in vivo;Infection;Infection Control;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;inflammatory modulation;Inflammatory Response;inhibitor;Innate Immune Response;Innate Immune System;knock-down;Knockout Mice;Ligands;Lipids;Macrophage;Membrane;Metabolic;Metabolism;Microbe;Mitochondria;monomer;mouse model;Mus;Myelogenous;Myeloid Cells;Outcome;Outer Mitochondrial Membrane;Pathology;Pathway interactions;Peptide Hydrolases;Peptidoglycan;Phagocytes;Phagosomes;Phenotype;Play;Polymers;Process;Production;Proteins;receptor;recruit;Regulation;Research;Resistance;response;Role;Signal Transduction;SLC2A1 gene;Small Interfering RNA;Staphylococcus aureus;sugar;Therapeutic;Tissues;Toll-like receptors;Vertebral column

PROJECT_TITLE: Mechanisms of peptidoglycan-induced modulation of metabolic and inflammatory responses to bacteria

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Chronic Obstructive Pulmonary Disease;Lung;Lung Cancer

ORG_CITY: Los Angeles

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative NF-B plays a causative role in the pathogenesis of lung and many other diseases. However, we have been unable to successfully target it for clinical treatment due to its equally important roles in physiology and host defense in particular. The proposed investigations will define the roles and mechanisms by which the ubiquitin E3 ligase PDLIM2 serves as a determinant of NF-B physiological and pathogenic activation in lung infection and pathogenesis. These studies may lead to new clinically feasible approaches to selectively target pathogenic NF-B for therapy.

PI_NAMEs: QU, ZHAOXIA  (contact);XIAO, GUTIAN

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Acetylation;Acute Lung Injury;Age;Automobile Driving;Bacteria;Binding;Biochemical;Biological Assay;Cell Line;Cells;Cessation of life;chromatin immunoprecipitation;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Treatment;Combined Modality Therapy;Complex;conditional knockout;Crystallography;Data;Deacetylation;Disease;Dissection;Endotoxins;Epithelial Cells;Epithelium;Exhibits;fighting;Functional disorder;Genetic Transcription;Host Defense;Human;human model;Immunology procedure;improved;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;innovation;Interstitial Lung Diseases;Investigation;Knock-in Mouse;Knock-out;Knockout Mice;LIM Domain;Lipopolysaccharides;Lung;Lung Diseases;Lung infections;lung injury;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Mediating;member;men;mimetics;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;neoplastic cell;new therapeutic target;NF-kappa B;novel;novel therapeutics;Nuclear;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patients;Pattern;Physiological;Physiology;Play;Predisposition;prevent;Proteins;recruit;Regulation;RELA gene;Repression;Ring Finger Domain;Role;Safety;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;Stimulus;Testing;Time;Tumor Suppressor Proteins;ubiquitin-protein ligase;Ubiquitination;United States;Woman

PROJECT_TITLE: Structural and molecular dissection of NF-kappaB regulation by the ubiquitin E3 ligase PDLIM2 in lung innate immunity and diseases


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Precision Medicine;Uterine Cancer;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Epidemiological and pre-clinical data suggest that metformin may be efficacious in endometrial cancer treatment. However, two important questions that need to be addressed are: (1) Will metformin be universally effective in endometrial cancer or be more efficacious in the obese/insulin-resistant patient population? and (2) What role do transporters play in metformin uptake and action in the malignant endometrium? These fundamental questions will be explored in endometrial cancer, a disease driven by obesity and insulin resistance, and key molecular and metabolic biomarkers of metformin responsiveness will be determined, using endometrial cancer mouse models and an ongoing phase 2/3 clinical trial in endometrial cancer patients.

PI_NAMEs: BAE-JUMP, VICTORIA LIN (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Address;Aftercare;anti-cancer;Biguanides;Biological Markers;Body mass index;Cancer Biology;Cancer cell line;Cancer Patient;cancer risk;cancer therapy;Carboplatin;Cations;Cells;Cessation of life;Characteristics;Chemoresistance;chemotherapy;Clinical Research;Clinical Trials;clinically relevant;Data;Databases;Diabetes Mellitus;diabetic patient;diet-induced obesity;Disease;Down-Regulation;Endometrial Carcinoma;Endometrial Neoplasms;Endometrium;Energy Metabolism;Epidemiology;Fasting;Fatty Acids;FRAP1 gene;Gene Expression;Gene Expression Profile;genetic signature;Genotype;Glucose;Glycolipids;Goals;Growth;Growth Factor;Human;Insulin;insulin regulation;Insulin Resistance;insulin signaling;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipid Synthesis Pathway;Lipids;lipoprotein lipase;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measurement;Metabolic;Metabolic Marker;metabolomics;Metformin;Modeling;Molecular;molecular marker;mouse model;mTOR inhibition;Mus;neoplastic cell;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;obese patients;obese person;Obesity;Oncology Group;Outcome;oxidation;Paclitaxel;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phase 0 Clinical Trial;Phase 0 Trial;Phase II/III Clinical Trial;Phase II/III Trial;Phenotype;Placebos;Play;pre-clinical;Pre-Clinical Model;preclinical study;predicting response;predictive marker;Production;Proliferating;Randomized;receptor;reproductive organ;Research;response;Risk;Role;Serum;Signal Transduction;standard of care;targeted agent;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Thinness;Toxin;tumor;tumor growth;Tumor Tissue;tumorigenic;Up-Regulation;uptake;Waist-Hip Ratio;Weight;Woman;Work

PROJECT_TITLE: Obesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Late-life depression remains an enormous public health burden, and deficits in motivation and pleasure are particularly devastating and difficult to treat. Using an experimental inflammatory challenge, the current study will evaluate a “two-hit” model of vulnerability and evaluate whether older adults with symptoms of anxiety who are exposed to inflammatory activation are at elevated risk for loss of pleasure, reduced reward motivation, and dysregulated reward neurocircuitry. Through this integrative, multilevel assessment of biological, neural and affective mechanisms that may underlie the emergence of late-life depression, the current study will yield information that can be used to identify individuals at elevated depression risk and to develop novel preventative and treatment interventions that target specific deficits to improve mental and physical health outcomes in older adults with depression.

PI_NAMEs: BOYLE, CHLOE  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Adverse effects;Affect;Affective;Age;Aging;Anxiety;anxiety symptoms;anxious;Automobile Driving;Behavior;behavior measurement;Behavioral;Biological;Biological Markers;Brain;Brain region;Chronic Disease;Clinical Trials;clinically significant;cognitive ability;Communities;comorbidity;Cues;daily functioning;Data;Data Analyses;Death Rate;Depressed mood;depression model;design;Detection;Development;Dimensions;disability;Double-Blind Method;Economics;Educational Status;Endotoxins;experience;Experimental Designs;Experimental Models;experimental study;Exposure to;Functional disorder;Future;Generalized Anxiety Disorder;geriatric depression;Health;High Prevalence;Impairment;improved;Individual;individual variation;Infection;Inflammaging;Inflammation;Inflammatory;insight;Intervention;Joints;Laboratories;late life;late-life anxiety;Link;Medical;Mental Depression;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Modeling;Monitor;Moods;mortality;Motivation;multilevel analysis;negative mood;neural;neural circuit;neuroimaging;neuromechanism;novel;older adult;Outcome;Pathway interactions;Peripheral;Personal Satisfaction;personalized medicine;pharmacologic;physical conditioning;Placebo Control;Placebos;Play;pleasure;Populations at Risk;Pre-Clinical Model;Predisposition;prevent;Prevention strategy;Process;programs;psychosocial;Public Health;recruit;Research;Research Personnel;response;reward circuitry;Rewards;Risk;Risk Factors;Role;Screening procedure;sex;sex disparity;skill acquisition;social;Social isolation;Specificity;suicidal risk;System;Techniques;Testing;Training;treatment strategy;Ventral Striatum;Work

PROJECT_TITLE: Experimental model of depression in aging: anxiety, inflammation, and reward mechanisms

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This proposal seeks to better understand the pathogenesis of neurodegenerative diseases. We will dissect defective endosomal pathways, which are common features in many neurodegenerative disorders including Alzheimer’s disease and Alzheimer’s disease related dementias. A fuller understanding of endosomal dysfunction will guide us to identify better therapeutic targets in neurodegenerative disorders and other aging- associated diseases.

PI_NAMEs: LEE, EUGENE Y (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Award;Axon;axonal degeneration;Axonal Transport;Biochemical;Cellular biology;Christianson syndrome;Cytoplasmic Tail;Data;Dedications;Defect;Deposition;Disease;endosome lumen;Endosomes;Functional disorder;Genes;Genetic study;Goals;GTPase-Activating Proteins;Histologic;Human;imaging modality;Impairment;innovation;interdisciplinary approach;Knowledge;late endosome;Link;live cell imaging;loss of function mutation;Lysosomes;Mediating;Mentors;Mentorship;Methodology;Methods;Microscope;microscopic imaging;Modeling;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;neuron loss;Neurons;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phase;Phenocopy;Physiological;Process;programs;Proteins;Protons;Publishing;Rattus;Reporting;Research;Resources;retrograde transport;skill acquisition;skills;Swelling;tau aggregation;tau Proteins;tau-1;Testing;therapeutic target;Time;Training;training opportunity;Transgenic Organisms;ultra high resolution;Work;X Chromosome

PROJECT_TITLE: NHE6-mediated endosomal defects in neurodegenerative disorders

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;HIV/AIDS;Human Genome;Immunotherapy;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: NARRATIVE Infants whose mothers have HIV, but who are themselves HIV-uninfected, experience more severe disease due to respiratory syncytial virus (RSV) infection than infants who are HIV-unexposed. This proposal will determine whether dysfunction in particular types of innate immune cells is responsible for more severe RSV disease in these infants, and will explore which in utero exposures contribute to this dysfunction. The results of this study have potential to improve health outcomes for more than 1 million HIV-exposed infants who are born each year.

PI_NAMEs: SMITH-ANDERSON, CHRISTIANA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;airway epithelium;Antigen-Presenting Cells;bead chip;Bioinformatics;Blood Cells;career;career development;Cell Physiology;Cells;Cessation of life;Coculture Techniques;cytokine;Data;Data Analyses;Defect;Disease;DNA Methylation;Endothelium;environmental enrichment for laboratory animals;Epigenetic Process;epigenome;Etiology;experience;Exposure to;fetal;Fetus;Functional disorder;Gene Expression;Genes;Genetic Transcription;genomic data;Genomics;Goals;Health;HIV;HIV Infections;HIV-exposed uninfected infant;Hospitalization;Human;human model;Hypermethylation;Immune;immune activation;immune function;Immune system;Immune System Diseases;Immunologics;Immunology;Impairment;imprint;improved;in utero;In Vitro;in vitro Model;Incubated;Infant;infant infection;infection risk;Inflammation;Inflammatory;inflammatory milieu;innate immune function;Innate Immune Response;innovation;Interferon Type II;Interleukin-10;Interleukin-12;Interleukin-6;International;Investigation;Knowledge;Laboratories;Learning;Life;Mentors;Mission;Modification;Mononuclear;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;Natural Killer Cells;Neonatal;Outcome;Pathway interactions;peer;perforin;Perinatal;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Play;Population;Pregnancy;Pregnant Women;prenatal exposure;Production;Research;Research Personnel;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;response;Role;seroconversion;Severities;Signal Transduction;single-cell RNA sequencing;skills;Supplementation;System;Techniques;Testing;TNF gene;Training;transcriptome;transcriptomics;Umbilical Cord Blood;Viral;Viral Pathogenesis;virology;Virus;Virus Diseases

PROJECT_TITLE: Innate Immune Defects in HIV-Exposed Uninfected Infants: Effect on Respiratory Syncytial Virus Infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative The Clinical Trials Network (CTN) is a cooperative agreement between NIDA, treatment providers, and researchers throughout the nation in which science is being utilized as a vehicle to improve the treatment of substance use disorders. It is the goal of the Southern Consortium Node (SCN) to work collaboratively with the CCTN, the NIDA-contracted coordinating and data centers, and other CTN Nodes in conducting and directing multi-site clinical trials, implementation and dissemination efforts.

PI_NAMEs: BARTH, KELLY S.;BRADY, KATHLEEN T. (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: addiction;Address;Area;care outcomes;Caring;clinical care;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Conduct Clinical Trials;Continuity of Patient Care;Contracts;cost;cost effective;Creativeness;Data Analytics;data centers;Development;Discipline;Disparity;Dissemination and Implementation;dissemination science;Education;evidence base;Evidence based treatment;flexibility;Funding;gaps in access;Geography;Goals;health care settings;health disparity;Health Personnel;Health system;Health Technology;Healthcare;Home;implementation science;improved;Individual;Informatics;Infrastructure;innovation;Leadership;Learning;medical specialties;Mission;Modeling;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Drug Abuse;Opioid;Patients;Performance;Primary Care;primary care provider;programs;Protocols documentation;Psychiatry;Research;Research Personnel;Research Project Grants;Resources;Rural;rural area;Rural Population;rural underserved;Science;Solid;Substance Use Disorder;substance use treatment;System;Technology;Testing;Training;treatment program;treatment research;U-Series Cooperative Agreements;Underserved Population;Work;Workforce Development

PROJECT_TITLE: Southern Consortium Node of the Clinical Trials Network


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Diabetes;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Today an intergenerational cycle of obesity and diabetes is being played out from mother to infant, but how this occurs is still only partially understood. Altered breast milk composition is one possible pathway that the proposed study aims to examine in detail. Results of the study will identify new targets for childhood obesity prevention.

PI_NAMEs: DEMERATH, ELLEN W. (contact);FIELDS, DAVID A

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 5 year old;Address;adiponectin;Age;Age Months;Biochemical;Birth;Blood Glucose;Body Composition;Body mass index;Body Weight;Breast Feeding;C-Peptide;Carbohydrates;Child;Child Health;cohort;Cohort Studies;cytokine;Desire for food;Diabetes Mellitus;diabetes risk;Dual-Energy X-Ray Absorptiometry;early childhood;Energy Metabolism;Enrollment;Epidemic;Epidermal Growth Factor;evidence base;Exclusive Breastfeeding;Exhibits;Fatty acid glycerol esters;feeding;Functional disorder;Future;Gestational Diabetes;ghrelin;Glucose;Goals;Grant;Growth;Growth Factor;high risk;Hormones;Hour;Human Milk;Hyperglycemia;Immunologic Factors;individual variation;infancy;Infant;Infant Health;infant outcome;Inflammatory;Insulin;inter-individual variation;intergenerational;Interleukin-6;Intestines;Knowledge;Lactation;Lactoferrin;Leptin;Life;Link;maternal obesity;Measures;member;Metabolic;metabolic rate;metabolomics;Methods;Milk;milk supply;mother nutrition;Mothers;non-diabetic;novel;Nutritional;Nutritional status;Obesity;obesity in children;obesity prevention;obesity risk;offspring;Oral;Outcome;Output;Overweight;oxidation;Pathway interactions;Phenotype;Play;Postpartum Period;Pregnancy;prepregnancy;prospective;prospective test;recruit;Research;Resolution;Resources;Rest;Risk;Role;Sampling;Satiation;Science;Serum;Specimen;standard measure;sweet taste perception;Taste preferences;Techniques;Test Result;Testing;therapy design;transmission process;Variant;Vertical Disease Transmission;Weight;Woman;women of color;Work

PROJECT_TITLE: Maternal Obesity, Milk Composition, and Infant Growth

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The goal of this project is the development of a clinical decision support tool that can be used to predict the risk of drug-induced QT prolongation based on deep learning and genetics. This tool could be used to prevent potentially fatal side effects of medications when alternatives are available, or increase vigilance when safer alternatives are not available. This study is specifically designed so that the models created can be directly applied across other institutional medical record systems beyond the study population.

PI_NAMEs: ROSENBERG, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Adherence;Adverse drug effect;analytical tool;Arrhythmia;Artificial Intelligence;Automated Clinical Decision Support;Benefits and Risks;biobank;Biometry;Cardiotoxicity;Certification;classification algorithm;Clinical;clinical application;clinical decision support;clinical implementation;clinical infrastructure;cloud based;cloud platform;cloud storage;Cluster randomized trial;Colorado;Custom;Data;data modeling;Data Science;data warehouse;Decision Analysis;deep learning;deep learning model;design;Development;disorder risk;DNA;drug market;Electrocardiogram;electronic health data;Electronic Health Record;Electronics;Excision;Exclusion;experience;Future;Genetic;genetic association;genetic epidemiology;genetic information;genetic predictors;Genetic Risk;genetic variant;genome wide association study;Genotype;Goals;health data;Health system;Health Technology;Healthcare;Heritability;Hospitals;improved;Individual;Information Technology;Infrastructure;innovation;Inpatients;insight;Institution;Investigation;Long QT Syndrome;Machine Learning;machine learning method;Maps;Marketing;Medical;Medical Informatics;Medical Records;medical schools;medical specialties;Methods;Modeling;multi-ethnic;Outcome;Outpatients;Participant;Patient risk;patient safety;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacogenomics;Physicians;polygenic risk score;Population;practical application;predictive modeling;prevent;primary outcome;Protocols documentation;Provider;Recording of previous events;Relative Risks;Research;Research Infrastructure;Research Personnel;response;Rest;Risk;risk prediction;Risk Reduction;risk stratification;Role;Sample Size;Sampling;Science;secondary outcome;side effect;study population;support tools;System;Technology;Testing;Time;tool;Torsades de Pointes;Toxic effect;trend;Universities;Validation;Variant;vigilance;Work

PROJECT_TITLE: Development of End-To-End Clinical Decision Support Tools To Prevent Cardiotoxic Drug Response

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This research is relevant to public health because it seeks to improve the Midlife Black Women’s Stress and Wellness Intervention (B-SWELL), a program co-designed with the community to lower heart disease risk in midlife Black women. This research study leverages choice to increase engagement and minimize the effect of social determinants of health on research participation. Findings from this study have potential to increase sustainability of the B-SWELL and our understanding about preferences of midlife Black women willing to participate in community-based interventions.

PI_NAMEs: JONES, HOLLY JANELL (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Achievement;Address;Adherence;Adoption;Affect;Age;American Heart Association;attentional control;Awareness;Behavior;Behavioral;Belief;Black race;black women;Blood Glucose;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder education;cardiovascular disorder risk;cardiovascular health;Case Study;Cholesterol;Chronic Disease;Chronic stress;Communities;community based participatory approach;community intervention;community planning;comparison control;Data;design;Development;Diet;Disadvantaged;Disparity;Educational Intervention;Effectiveness;Evaluation;Event;Exercise;Exhibits;experience;falls;feasibility trial;Future;Gender;Goals;group intervention;Guilt;Health;health disparity;health equity;Health Promotion;healthy lifestyle;heart disease risk;improved;Incidence;insight;Insurance;intersectionality;Intervention;intervention participants;Knowledge;lens;Life;Life Stress;Life Style;Literature;Manuals;Measures;Mediator;middle age;Modification;mortality;Myocardial Infarction;operation;Outcome;Outcome Measure;Paper;Participant;peer;perceived stress;Persons;phase II trial;pilot trial;poor health outcome;Populations at Risk;post intervention;preference;Prevention;Preventive care;Procedures;Process;programs;Public Health;Race;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;research study;Resources;Risk;satisfaction;Self Care;Self Efficacy;Sleep;social health determinants;Stress;stress reduction;stressor;Subgroup;Symptoms;Tablets;Target Populations;Technology;Testing;theories;therapy design;therapy development;Time;Tobacco use;Training;trend;virtual;Weight;White Women;Woman;Women's study;Work

PROJECT_TITLE: Modification of the B-SWELL Intervention to Improve Long Term Outcome Trends in Midlife Black Women

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Mental Illness;Neurosciences;Sleep Research

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The hypothalamic hypocretin (Hcrt) neurons play a central role in integrating sensory and physiological information to tune arousal-related behavioral states, and deficiencies in these circuitries contribute to a variety of neuropsychiatric disorders. In this collaboration between researchers studying arousal-related behavioral states and BRAIN tool developers we will utilize novel interventional tools for changing neural circuit dynamics to elucidate the hierarchical organization of Hcrt circuits with respect to arousal and reward. Our exploratory studies will drive translational progress toward optimization of treatments and potential novel therapeutic opportunities in substance abuse, eating and panic disorders, cognitive disruption and emotion-related disorders, while at the same time addressing basic questions of neural circuit function underlying behavior relevant to both NINDS and NIMH.

PI_NAMEs: DE LECEA, LUIS ;HOCHGESCHWENDER, UTE H (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Anatomy;antagonist;Anxiety;Area;Arousal;Behavior;behavior test;Behavioral;Brain;Cells;Clinical Trials;Cognition;Cognitive;Collaborations;Communication;craving;Development;Disease;Dissection;dopaminergic neuron;Eating Disorders;Emotions;experimental study;feeding;Fright;Goals;hypocretin;Hypothalamic structure;Individual;Intervention;Knowledge;Lateral;Learning;Light;light emission;Link;locus ceruleus structure;Luciferases;luciferin;Mediating;Methods;motivated behavior;motivational processes;mouse model;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;neural circuit;neuromechanism;Neurons;neuropsychiatric disorder;neurotransmission;noradrenergic;novel;novel therapeutics;Opsin;Optics;optogenetics;Output;Panic Disorder;Peripheral;Physiological;Play;Post-Traumatic Stress Disorders;postsynaptic;postsynaptic neurons;presynaptic;receptor;Regulation;Research Personnel;Rewards;Role;sensory integration;Sleep;Sleeplessness;Source;Stress;Structure;Substance abuse problem;Synapses;Synaptic Vesicles;System;Testing;Therapeutic;Time;tool;translational progress;treatment optimization;Ventral Tegmental Area;Viral Vector;Wakefulness;Weight

PROJECT_TITLE: Functional circuit dissection of the Hcrt system

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Alzheimer’s disease (AD) and dementia pose an enormous public health, economic, and social burden to the United Sates. Outcome of this proposal will advance our understanding the risk factors for AD and dementia and provide a novel disease model, which will facilitate developments of preventive and therapeutic strategies.

PI_NAMEs: POLSTER, BRIAN M (contact)

PROJECT_TERMS: abeta accumulation;abeta oligomer;Age;age-related disease;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Behavioral Assay;Biochemical;Biological Assay;Blood;Brain;Cause of Death;Cerebellum;Clinical;Complex;Country;Dementia;dementia risk;Development;differential expression;Disease;disease model;Disease susceptibility;disease-causing mutation;Early Diagnosis;early onset;Early Onset Alzheimer Disease;Economic Burden;Economics;Embryo;Environmental Risk Factor;Epigenetic Process;Evaluation;Female;Genes;Genetic;Goals;High Prevalence;Histopathology;Human;Impaired cognition;Impairment;improved;In Vitro;Individual;inhibitor;Knock-in Mouse;Knock-out;knockout gene;Learning;life span;Link;male;Memory;Meta-Analysis;Microtubule Depolymerization;Mitochondria;Mitochondrial complex I deficiency;Modeling;Molecular;Mus;mutant;Mutation;NADH dehydrogenase (ubiquinone);Nature;Neurofibrillary Tangles;neuroinflammation;neuron loss;novel;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Patients;pharmacologic;Population;Predisposition;Prevention;Preventive;Production;Proteins;Proteomics;Public Health;Reactive Oxygen Species;Reporting;Respiratory Chain;Rest;Risk;Role;Rotenone;Senile Plaques;sex disparity;social;Substantia nigra structure;Synapses;Testing;Therapeutic;Time;Tissues;Transcript;trend;United States;X Chromosome

PROJECT_TITLE: Role of mitochondrial Complex I deficiency in Alzheimer disease and dementia

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Disability Research;Nutrition;Prevention;Rehabilitation

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Dietary factors including dietary quality and dietary patterns are modifiable lifestyle behaviors associated with age-related declines in physical function. This study proposes to identify plasma metabolite biomarkers of diet that mediate the associations between dietary factors with physical function, frailty and disability in older age.

PI_NAMEs: TALEGAWKAR, SAMEERA A (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Age;age related;age related decline;Aging;aging related;Area;Baltimore;Behavior;Behavioral;Biological;Biological Markers;Body Composition;brain health;Cardiovascular Diseases;Cessation of life;Chronic Disease;cognitive function;cohort;Cohort Studies;DASH diet;Data;Development;Diet;dietary;Dietary Factors;Dietary Practices;disability;disability risk;Disease;Disease Progression;Environmental Risk Factor;Epidemiology;epidemiology study;follow-up;Food;frailty;Goals;Hand Strength;Health;high risk;Home Nursing Care;Hospitals;human old age (65+);indexing;Individual;Inflammatory;Institutionalization;instrumental activity of daily living;Intake;Intervention;Intervention Studies;Investigation;Knowledge;Life Style;Liquid Chromatography;Longitudinal Studies;Measures;Mediating;Mediterranean Diet;Metabolic;metabolic phenotype;metabolomics;Methods;modifiable lifestyle factors;mortality risk;muscle strength;Nerve Degeneration;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;older adult;Older Population;Outcome;Outcome Study;Pathway interactions;Personal Satisfaction;Phenotype;Physical Function;Physical Performance;Plasma;Play;Prevention strategy;Principal Component Analysis;Process;prospective;Prospective cohort;Public Health;Quality of life;Research;Research Personnel;Risk;Role;Specimen;tandem mass spectrometry;Therapeutic Intervention;Woman;Work

PROJECT_TITLE: Plasma metabolite markers of dietary factors associated with age-related declines in physical function

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: BOCA RATON

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: 8. Project Narrative. PD1 is an immune checkpoint protein that acts as a brake on signaling proteins that trigger an innate immune response to cancer and ultimately allow tumor evasion. While FDA-approved monoclonal antibodies provided compelling clinical results in various cancer types, the development of small-molecule drugs inhibiting such protein–protein interaction (PPI) is lagging far behind. To bridge this gap, and reignite antitumor immunity to inhibit the growth of these immunosuppressive tumors, we are developing β-hairpin drugs that closely mimic and miniaturize antibody loops while covalently binding to PD1.

PI_NAMEs: ROCHE, STEPHANE P (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Affinity;Alanine;Amino Acids;antagonist;anti-PD-L1;Antibodies;Antibody Binding Sites;antibody libraries;Antibody Specificity;Area;bak protein;Binding;bioactive scaffold;Biological Assay;Biological Process;Biological Products;Calorimetry;cancer cell;cancer immunotherapy;cancer type;Cells;Chemicals;Clinical;Complex;CTLA4 gene;design;Development;Disease;drug discovery;effector T cell;Epitopes;exosome;Extracellular Protein;FDA approved;Genes;Goals;Growth;immune checkpoint;immune checkpoint blockade;immune checkpoint blockers;Immune checkpoint inhibitor;Immune response;Immunooncology;In Vitro;in vivo;inhibitor;inhibitor therapy;Innate Immune Response;Kinetics;Laboratories;Lead;Length;Libraries;Ligands;Lysine;Malignant Neoplasms;Mammalian Cell;mimicry;miniaturize;Modality;Modernization;Molecular Conformation;Monoclonal Antibodies;neoplastic cell;NMR Spectroscopy;novel;novel therapeutics;OX40;PDL1 inhibitors;Penetration;peptide drug;Peptides;Permeability;Pharmaceutical Preparations;Play;Point Mutation;Positioning Attribute;preclinical study;preservation;Process;programmed cell death ligand 1;programmed cell death protein 1;Protein Inhibition;protein protein interaction;protein structure;Proteins;Proteomics;rational design;Research;response;Roentgen Rays;Role;scaffold;Scanning;screening;Series;Signal Pathway;Signaling Protein;Site;small molecule;Structure;success;Surface;T-Cell Proliferation;Technology;tool;tumor;Tumor Escape;Tumor Immunity;Visit;Water;Work

PROJECT_TITLE: Covalent PD1 Antagonists: Discovery of Protein-Protein Interaction (PPI) Inhibitors in Cancer Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Klebsiella pneumoniae is a leading cause of nosocomial and community-acquired pneumonia. Genetic polymorphisms and inflammatory mediators play critical roles in Klebsiella pneumonia pathogenesis. We will investigate how a common leptin receptor polymorphism affects host defense against bacterial pneumonia.

PI_NAMEs: MANCUSO, PETER  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute Lung Injury;Affect;Alleles;Antimicrobial Resistance;Applications Grants;Arginine;Bacterial Infections;Bacterial Pneumonia;Blood;Body mass index;Cells;Clinical Data;Clostridium difficile;community acquired pneumonia;cytokine;Data;Disease;Eicosanoids;Entamoeba histolytica;Event;Exhibits;experimental study;Extracellular Domain;General Population;Genes;Genetic;Genetic Polymorphism;genomic data;Genomics;Genotype;Glutamine;Goals;Heterozygote;Host Defense;Human;IL8RB gene;Immune response;Impairment;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interferon Type II;Interleukin-1 beta;Interleukin-6;Intra-abdominal;ITGAM gene;Klebsiella Infections;Klebsiella pneumoniae;Leptin;leptin receptor;Leptin receptor mutation;Leukocytes;Lung;Lung infections;lung injury;Messenger RNA;Michigan;mortality;mouse model;Mus;Mutation;neutralizing antibody;neutrophil;Neutrophil Infiltration;Neutrophilia;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Peritonitis;Phagocytosis;Play;Positioning Attribute;receptor;Receptor Gene;Receptor Signaling;recruit;Reporting;resistant strain;Risk Factors;Role;Severities;Signal Pathway;Spleen;synthetic enzyme;targeted treatment;Testing;Tissues;TNF gene;translational medicine

PROJECT_TITLE: Q223R Leptin Receptor Polymorphism in Bacterial Pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Suicide is a global public health concern, especially in low- and middle- income countries where more than 77% of all suicides occur, disproportionately impacting youth. The Zero Suicide model, comprised of a series of evidence-based approaches, has now been implemented in more than 20 countries, but the feasibility of these approaches in LMICs is unclear. The proposed R21 project leverages an established research collaboration and strong governmental support to examine the feasibility of these suicide prevention approaches for youth in Nepal and to develop strategies for implementation through stakeholder surveys, interviews, and focus groups.

PI_NAMEs: AHMEDANI, BRIAN KENNETH (contact);BAJRACHARYA, DEEPAK C.;KALJEE, LINDA M

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Acute;Address;Administrator;Adopted;Affect;Area;Asia;behavioral health;care coordination;Caring;Cause of Death;Clinic;Clinical;clinical care;Collaborations;Collection;Communities;community clinic;Community Hospitals;community organizations;community partnership;Consensus;Consolidated Framework for Implementation Research;Country;Data;design;Effectiveness;effectiveness trial;Evaluation;evidence base;Family;Federal Government;Focus Groups;Foundations;Future;Goals;Government;Government Agencies;Health;Health Services;Health system;Healthcare;help-seeking behavior;Hospitals;Human Resources;Hybrids;implementation evaluation;implementation facilitation;implementation framework;implementation strategy;improved;Income;Individual;Infrastructure;interest;International;Intervention;intervention mapping;Interview;Learning;Local Government;Location;Logistics;low and middle-income countries;meetings;Mental Health;Methods;Modeling;National Institute of Mental Health;Nepal;Parents;patient screening;Patients;Penetration;Perception;Persons;Population;Prevention;Prevention approach;Prevention strategy;Process;programs;Provider;Psychotherapy;public education;Public Health;Recommendation;reducing suicide;Research;Research Infrastructure;Resources;Risk Assessment;Safety;Schools;screening;Series;Severities;social stigma;standard care;stressor;success;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Surveys;symposium;Testing;Training;treatment planning;UNICEF;United States;Work;World Health Organization;Youth

PROJECT_TITLE: Implementation Strategies for Suicide Prevention among Youth in Nepal

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NORTHPORT

ORG_NAME: NORTHPORT VA MEDICAL CENTER

ORG_STATE: NY

PHR: This project examines the mechanisms by which the hormones insulin and insulin-like growth factor-1 (IGF1) transmit their signals inside target cells. The receptors for these hormones are linked to human disease: decreased insulin receptor activity is linked to diabetes, while increased activity of IGF1 receptor plays a role in cancer. The structural and biochemical information from these studies could be used to design new therapies to control receptor activity in these diseases.

PI_NAMEs: MILLER, W TODD (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Aging;Agonist;Allosteric Regulation;Allosteric Site;Applications Grants;Binding;Biochemical;Biological;Biological Assay;Cell Communication;cell growth;Cell membrane;Cell Surface Receptors;Cells;Cellular Metabolic Process;Chinese Hamster Ovary Cell;Complex;Computing Methodologies;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Tail;Data;density;design;Detergents;Diabetes Mellitus;dimer;Dimerization;Disease;Disulfides;Docking;drug discovery;Environment;experimental study;Extracellular Domain;Family;Fluorescence Resonance Energy Transfer;growth hormone regulating factor;Hepatocyte;Hormone Receptor;Hormones;human disease;Hydrophobicity;In Vitro;Individual;inhibitor;Insulin;Insulin Receptor;insulin receptor tyrosine kinase;insulin regulation;insulin signaling;Insulin-Like Growth Factor I;insulin-like signaling;Insulin-Like-Growth Factor I Receptor;Knowledge;Length;Ligand Binding;Ligands;Link;Lipids;Liquid substance;Lobe;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;member;Membrane;Metabolism;Methodology;Molecular;Molecular Conformation;Monitor;Mus;Mutagenesis;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;particle;Phospholipids;Phosphorylation;Phosphotransferases;Polypeptide Hormones;Positioning Attribute;Preparation;Protein Tyrosine Phosphatase;protein tyrosine phosphatase 1B;Proteins;Protocols documentation;PTPN1 gene;receptor;receptor function;Receptor Protein-Tyrosine Kinases;Receptor Signaling;reconstitution;recruit;Regulation;response;screening;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Site;small molecule;Specificity;Sphingolipids;Sterols;Stimulus;Structure;System;Techniques;Testing;transmission process;Tyrosine Kinase Domain;Vesicle;virtual;Western Blotting;Work

PROJECT_TITLE: Structural and biochemical studies of receptor tyrosine kinases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CAMM-P (01)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Ultrasound imaging of the coronary and peripheral arteries during procedures like balloon angioplasty or stent placement is known to improve outcomes, but it is infrequently used because of interpretation complexity and added procedure time for exchanging specialized imaging catheters. This project focuses on incorporating this capability on devices like guidewires and catheters that are routinely used in these procedures so that physicians can use this technique before, during and after the interventions without prolonging the procedure duration.

PI_NAMEs: DEGERTEKIN, F. LEVENT (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;3D Print;Angiography;Animals;arterial tortuosity;Arteries;Balloon Angioplasty;calcification;Catheters;cold temperature;Collaborations;Complex;Computer software;Consumption;Coronary;Coronary heart disease;Coupled;Data;Data Analyses;Data Collection;design;Development;Devices;Electrodes;Electronics;Elements;Evaluation;experimental study;fabrication;Feedback;Film;flexibility;Frequencies;Geometry;Goals;Image;Image Analysis;imager;Imaging Device;imaging probe;implantation;improved outcome;In Situ;in situ imaging;Industrialization;integrated circuit;Intervention;Length;lithography;Maps;Measurement;Measures;Mechanics;Methods;metrology;miniaturize;Modality;Monitor;Morbidity - disease rate;Motion;neurovascular;novel;operation;optical fiber;Optics;Pattern;percutaneous coronary intervention;Performance;Peripheral;Peripheral arterial disease;Phase;Physicians;Physiologic pulse;Polymers;Positioning Attribute;pressure sensor;Printing;Procedures;Process;reconstruction;Resolution;Rotation;Sampling;Scheme;Silicon;simulation;Stents;Stroke;Structure;System;Techniques;Technology;Thinness;Time;tool;Transducers;Ultrasonography;ultrasound;Universities

PROJECT_TITLE: Flexible piezo film intravascular ultrasound arrays on guidewires and catheters

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Discovery of human metapneumovirus epitopes Our lab has established methods to discover human MHC-I and MHC-II epitopes using HLA-transgenic mice and human PBMCs. We propose to apply these methods to human metapneumovirus (HMPV) to discover HLA-restricted T cell epitopes recognized by CD4+ and CD8+ T cells. These tools will be needed to understand human immune responses to both natural infection and vaccines against this important human respiratory pathogen.

PI_NAMEs: WILLIAMS, JOHN V. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 5 year old;Adult;Alleles;Anti-viral Therapy;Antibody Response;Asthma;Biological Assay;bone;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Chronic Obstructive Pulmonary Disease;Clinical;comorbidity;cytokine;Data;Dengue Vaccine;design;Development;Dimensions;Disease;early childhood;enzyme linked immunospot assay;Epitopes;experimental study;falls;Flow Cytometry;Formalin;Goals;Government;Granzyme;HIV;HLA-A gene;Hospitalization;Human;Human Metapneumovirus;Immune;Immune response;Immunity;Immunize;Immunocompromised Host;immunogenicity;immunopathology;Individual;Industry;Infection;Interferon Type II;Interleukin-2;Life;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung histology;Mediating;Methods;mouse model;Mus;older adult;Pathogenesis;pathogenic virus;Pathology;Patients;peptide vaccination;Peptides;perforin;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;Population Heterogeneity;pre-clinical;premature;Production;protective efficacy;Pulmonary Pathology;receptor expression;Research;Research Personnel;respiratory pathogen;Respiratory syncytial virus;response;Severity of illness;Stains;T cell response;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;TNF gene;tool;transcription factor;Transgenic Mice;United States National Institutes of Health;Vaccination;vaccine candidate;vaccine development;Vaccines;Viral;Virulent;Virus;Weight

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: NARRATIVE There is a pressing need to develop vaccines that reduce the burden of norovirus in children. To guide these vaccination strategies, we must better understand natural norovirus immunity at the maternal-child interface. This project connects a robust field site in Guatemala with state-of-the-art immunological approaches to inform norovirus vaccination strategies that benefit children.

PI_NAMEs: BECKER-DREPS, SYLVIA IRENE (contact);OLSON, DANIEL

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Adult;Age;Antibodies;Antibody Response;Antigens;Appearance;Attention;Breast Feeding;Breastfed infant;Child;Childhood;Clinical Trials;Data;Disease;Dose;Enrollment;epidemiology study;Exclusive Breastfeeding;experience;Feces;feeding;Frequencies;Future;Gastroenteritis;Genotype;Goals;Guatemala;Guatemalan;Heterophile Antibodies;Household;Human;Human Milk;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunologics;infancy;Infant;Infection;insight;Integration Host Factors;Kinetics;Lactation;Life;Liquid substance;Maternally-Acquired Immunity;Measures;Mothers;Mucous Membrane;Natural Immunity;Nature;Norovirus;novel;Oral;Passive Immunity;Phase;Placenta;Postpartum Period;Predisposition;Research;response;Risk;Role;Rotavirus Vaccines;Saliva;Sampling;Serum;Site;Symptoms;Testing;Time;transmission process;Vaccination;vaccination strategy;vaccine candidate;vaccine development;Vaccines;Viral Gastroenteritis;Virus Shedding;Weaning;Woman

PROJECT_TITLE: Norovirus immunity at the maternal-child interface

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Genetics;Hematology

PHR: PROJECT NARRATIVE Hypoxia and oxidant stress are important physiological processes that can have significant effects on human health. Red blood cells, the most abundant cell type in the body, play a critical role in oxygen transport, a process that is mediated by hemoglobin and iron. Indeed, 66% of bodily iron is stored in red cells. Dysregulated iron metabolism has been shown to promote oxidative stress. Oxidant stress promotes lipid peroxidation, a hallmark of cell death by a mechanism referred to as “ferroptosis”. Red blood cells not only harbor many of the enzymes involved in the regulation of ferroptosis, but iron-induced oxidant stress is an established regulator of red cell aging and clearance in circulation. In this project we will leverage recently developed genetic and pharmacological tools to mechanistically test the role of ferroptosis on red blood cell aging, both in circulation in vivo and in vitro, during storage in the blood bank for transfusion purposes, a life-saving intervention for ~5 million Americans every year, ranked 1st in the list of historical breakthroughs that saved the most human lives (1 billion).

PI_NAMEs: D'ALESSANDRO, ANGELO  (contact);ZIMRING, JAMES C.

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Adult;Affect;African;Aging;Altitude;American;Anemia;Antioxidants;Area;Birth;Blood;Blood Banks;Blood Circulation;blood glucose regulation;Carcinogens;Cell Aging;Cell Death;Cell Death Process;Cell Nucleus;cell type;Cells;Chemistry;Circulation;Cysteine;Down-Regulation;Drug Metabolic Detoxication;Electrons;enzyme pathway;Enzymes;Erythrocyte Transfusion;Erythrocytes;Erythropoiesis;Etiology;Exercise;Exposure to;Face;Funding;gain of function;Genes;Genetic;genetic manipulation;Genetic Polymorphism;Genetic study;Genetic Transcription;Germ-Line Mutation;Glucose;Glutathione;Glutathione Disulfide;glutathione peroxidase;Hallmark Cell;Health;Hematopoiesis;Hematopoietic stem cells;heme a;Heme Group;Hemoglobin;Hemolysis;Hospitals;Human;Human body;Hypoxia;In Vitro;in vitro Model;in vivo;Individual;Inherited;inorganic phosphate;Intervention;Iron;iron (III) reductase;iron metabolism;Life;life span;Link;Lipid Peroxidation;Logistics;Malignant - descriptor;Malignant Neoplasms;Mediating;Medical;Metabolism;methyl group;metropolitan;Mitochondria;Modeling;mouse model;Mouse Strains;Mus;Mutate;Mutation;NADP;novel;Organ;Organelles;oxidant stress;Oxidants;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidoreductase;Oxygen;oxygen transport;Pathologic;Pathway interactions;Pentosephosphate Pathway;Peptides;Peripheral;Persons;pharmacologic;Physiological Processes;Play;Population;Prevalence;prevent;Procedures;Process;Protein Biosynthesis;Proteins;Public Health;Reactive Oxygen Species;Recording of previous events;Recovery;Recycling;Regulation;repaired;Residual state;response;Role;six transmembrane epithelial antigen of the prostate 3;Somatic Mutation;System;Testing;Time;Tissues;tool;TP53 gene;Transfusion;tumor;Up-Regulation;uptake;Vaccination;Variant;volunteer

PROJECT_TITLE: The role of ferroptosis in red cell aging in vivo and in vitro

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Early life sleep disruption is common in autism spectrum disorder and has been shown in animal models to cause lasting changes in brain function and behavior. Treatments for sleep disruption in children are extremely limited, and the basis for vulnerability to early life sleep disruption is not known. Here we will test whether mutation in a known autism risk gene confers vulnerability to the effects of developmental sleep disruption, and whether the developing synapse is a node of vulnerability to the effects of sleep disruption.

PI_NAMEs: DIERING, GRAHAM HUGH (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adolescent;Adult;Affect;Animal Model;autism spectrum disorder;Behavior;behavior test;Biological Assay;Brain;Budgets;Child;chromatin remodeling;Cognitive;cohort;comorbidity;critical period;Data;density;Development;Diagnosis;Drosophila genus;Embryonic Development;Enzymes;Equilibrium;Excitatory Synapse;expectation;Exploratory/Developmental Grant;Exposure to;flexibility;Functional disorder;Genes;Genetic Predisposition to Disease;Goals;Heterozygote;Hippocampus;Impairment;Individual;Inhibitory Synapse;Life;Literature;Medicine;Methodology;model of autism spectrum disorder;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;next generation;Nuclear;Patients;Phenotype;Play;Positioning Attribute;postnatal;Predisposition;programs;Prosencephalon;Proteins;Proteomics;Publishing;Research;resilience;Risk Factors;risk variant;Rodent;Role;Sampling;Scaffolding Protein;Severities;sex;Sleep;Sleep Deprivation;Sleep disturbances;social;Social Behavior;Standardization;Structure;success;Symptoms;Synapses;synaptic function;synaptogenesis;Testing;Work

PROJECT_TITLE: Developmental sleep disruption interacts with underlying CHD8 genetic vulnerability in autism spectrum disorder

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related;Women's Health Research

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The generation of memory T cells that remain long-lived in the female reproductive tract (FRT) can enhance host protective immunity from sexual transmission of Chlamydia Trachomatis (C. trachomatis), a causative agent of severe diseases in women and an important global human health issue. Although the local tissue environments of the FRT differentially influence tissue resident memory T cell (TRM) immune surveillance, how regionalization with different parts of the FRT impacts T cell durability to influence the memory responses against Chlamydia is unknown. The goal of this proposal is to determine the mechanisms that imprint memory T cells to preferentially reside in the uterine, cervical, and vaginal FRT mucosae in order to better inform prevention efforts and cell- mediated vaccine designs against sexually transmitted pathogens in women.

PI_NAMEs: KOHLMEIER, ALISON SWAIMS (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Anatomy;Animal Model;Antigens;Antimicrobial Resistance;Automobile Driving;Bioinformatics;Cartoons;CD8B1 gene;Cells;Cellular Immunity;Cervical;Cervix Uteri;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;chronic pelvic pain;Circulation;Cues;Disease;Disease Surveillance;Ectopic Pregnancy;Environment;Epithelium;Female Adolescents;female reproductive tract;female reproductive tract infection;fitness;Gene Expression;Generations;genital infection;Genitalia;Genitourinary system;Genitourinary System Infection;Goals;Health;HIV-1;Homeostasis;Human;human female;Immune;immune function;Immune response;Immunity;Immunologic Memory;Immunologic Stimulation;Immunologic Surveillance;imprint;Incidence;Incidence Study;Infection;infection rate;Infertility;interest;Intestines;Investigation;Left;Longevity;Lung;Mechanics;Mediating;Memory;Menstrual cycle;Molecular;mucosal site;mucosal vaccine;Mucous Membrane;Neisseria gonorrhoeae;novel strategies;pathogen;pathogen exposure;Play;Prevalence Study;prevent;Prevention;Prevention strategy;Public Health;Regional Anatomy;Regulation;reproductive tract;Research Personnel;resistant strain;response;Risk;Role;secondary infection;Severity of illness;Sexual Transmission;Sexually Transmitted Diseases;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Site;Skin;Sorting;Streptococcus Group B;Structure;Supporting Cell;T cell receptor repertoire sequencing;T memory cell;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;transcriptomics;United States;Uterus;Vaccination;vaccine access;Vaccine Design;vaccine development;Vaccines;Vagina;vaginal mucosa;Woman

PROJECT_TITLE: Enhancing memory T cell defense in the female reproductive tract.


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Malaria parasites use numerous invasion ligand proteins to invade red blood cells (RBCs). We propose to globally identify all invasion ligand proteins capable of binding RBCs and identify proteins that interact with RBC host receptors. Understanding such interactions is key to developing a blood stage malaria vaccine.

PI_NAMEs: KANJEE, USHEER  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Africa South of the Sahara;Amino Acids;Antibodies;antibody test;B-Lymphocytes;Bacteria;Binding;Binding Proteins;Biological Assay;Biology;Biotin;Biotinylation;Blood;candidate validation;Catalogs;CD147 antigen;Cell Line;Cell Surface Receptors;Cessation of life;Clinical;Communicable Diseases;comparative;Complex;Coupled;Daughter;Defect;Detection;Development;Disease;Epitopes;Erythrocytes;Erythroid Cells;experimental study;Flow Cytometry;Future;Generations;Genes;Germ;Glycophorin B;glycosylation;GYPA gene;Human;Incubated;Individual;Infection;Intervention;Invaded;knock-down;Knock-out;Label;Length;Ligand Binding;Ligands;Malaria;malaria infection;Malaria Vaccines;Mammalian Cell;Mediating;Medical;Methods;Mineral Oil;Monoclonal Antibody Therapy;new therapeutic target;novel strategies;novel therapeutic intervention;parasite invasion;Parasites;Pattern;Persons;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Process;protein complex;protein folding;protein function;Proteins;Proteomics;Protocols documentation;Public Health;Radiolabeled;receptor;Recombinants;Reporting;Role;Sensitivity and Specificity;Serum-Free Culture Media;Sodium Chloride;Specificity;STAT2 gene;Streptavidin;Surface;Symptoms;System;Testing;therapy development;Time;Vaccines;Validation;Western Blotting;Wheat

PROJECT_TITLE: Functional characterization of the Plasmodium falciparum invasion ligand bindome

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cannabinoid Research;Clinical Research;Maternal Health;Maternal Morbidity and Mortality;Natural Products;Nutrition;Pediatric;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative As cannabis legalization expands, cannabis use and perceptions that use has little-to-no risk are increasing among reproductive-aged women. Yet, we lack information on whether and/or how cannabis use alters holistic human milk composition, frequently the only or primary source of nutrition for infants in their first months of life. Understanding the effects of maternal cannabis use on milk composition will provide needed information for healthcare providers and mothers to make evidence-based decisions that support breastfeeding and the health of the mother and infant.

PI_NAMEs: MEEHAN, COURTNEY LYNNE (contact)

PROJECT_TERMS: Affect;Age;aged;Body mass index;Breast Feeding;Cannabinoids;Cannabis;cannabis use behavior;Characteristics;Collection;Conflict (Psychology);Consumption;Control Groups;Country;Data;Development;Dietary intake;Dose;Drug Kinetics;Ethnic Origin;evidence base;Exposure to;Foundations;Frequencies;Future;Geography;Goals;Health;health knowledge;health of the mother;Health Personnel;Human;Human Milk;Individual;Individual Differences;infancy;Infant;Infant Development;Infant Health;infant nutrition;innovation;Knowledge;Lactation;Lactose;Life;lipidome;lipidomics;Lipids;lipophilicity;Mammary gland;marijuana legalization;marijuana use;Maternal Health;Maternal Health Services;maternal marijuana use;metabolome;metabolomics;Milk;milk production;Mothers;Motor;multiple omics;novel;nutrition;Outcome;Parents;Pathway interactions;Patient Self-Report;Pattern;Perception;Pharmaceutical Preparations;Population;postnatal;Postpartum Period;Pregnancy;prenatal;Proteome;Proteomics;repository;reproductive;Research;Research Design;Risk;Sample Size;Sampling;Secretory Immunoglobulin A;Source;Standardization;substance use;Testing;Tetrahydrocannabinol;Time;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: Cannabis, Human Milk, and Multi-omics

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Cystic Fibrosis;Genetic Testing;Genetics;Infant Mortality;Lung;Pediatric;Prevention;Rare Diseases

ORG_CITY: TUSCALOOSA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Newborn screening detects life-threatening genetic disorders early, allowing for effective treatment. Screening for a disorder is based on an algorithm, that is, a set of tests and rules on how to interpret the test results. We propose to develop a prescriptive optimization framework for designing optimal screening algorithms that will improve the efficacy, equity, and efficiency of current practices, using cystic fibrosis as a model disorder.

PI_NAMEs: BISH, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: African American population;Alabama;Algorithm Design;Algorithms;autosome;Avena sativa;Blood;Budgets;California;Cations;Characteristics;Chlorides;Collaborations;Complex;cost;Cystic Fibrosis;Data;Data Analytics;data-driven model;demographics;design;Diagnostic tests;Disease;disease model;Disparity;DNA;DNA sequencing;Dryness;effective therapy;Effectiveness;Equity;Ethnic Population;Genes;Genetic Diseases;genetic testing;Goals;Health;immunoreactivity;improved;Life;Literature;Methodology;Methods;Modeling;models and simulation;Mutation;Neonatal Screening;New York;Newborn Infant;novel;Outcome;Play;Population;Predictive Analytics;Prevalence;Process;Public Health;racial diversity;racial population;Recommendation;Reporting;Research;Resources;risk prediction;screening;screening program;simulation;Spottings;stem;Structure;Test Result;Testing;Trypsinogen;Uncertainty;United States;Universities;Variant;virtual

PROJECT_TITLE: Optimal newborn screening algorithms - efficacy and equity

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE We focus on understanding how human cells repair DNA double strand breaks induced via environmental exposures and protect stressed replication forks against attrition mediated by nucleases. Specifically, we will elucidate the role of the dual specificity phosphatase EYA4 in genome repair and maintenance pathways. The results from our endeavors will help fill a major knowledge gap regarding cellular defense against the cytotoxic and genotoxic effects of environmental clastogens.

PI_NAMEs: DRAY, ELOISE  (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Air Pollutants;Amino Acids;Aneuploidy;base;Biochemical;Biochemistry;Biological;Biological Assay;Biological Process;Cell Survival;Cells;Cellular biology;Chemical Exposure;Chemicals;Chromosomal Rearrangement;Chromosome Breakage;clastogen;Complex;cytotoxic;Cytotoxic agent;Defect;DNA;DNA Binding;DNA Binding Domain;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;Environment;Environmental Exposure;Environmental Protection;Event;Excision;Foundations;Genome;Genome Stability;Genomics;genotoxicity;Heavy Metals;homologous recombination;Human;Impairment;Industrialization;insight;Ionizing radiation;Knowledge;Lesion;Libraries;Maintenance;Malignant Neoplasms;Mediating;Mutagens;mutant;Nature;Nervous System Disorder;nuclease;Outcome;Pathway interactions;Pesticides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;Post-Translational Regulation;Premature aging syndrome;Protein Dephosphorylation;Protein phosphatase;Protein Serine/Threonine Phosphatase;Protein Tyrosine Phosphatase;Proteins;Proteome;Radiation;recombinase;repaired;replication stress;response;Role;Serine;Signal Transduction;Specificity;Stress;Structure;Threonine;Time;Tyrosine;Tyrosine Phosphorylation;Ubiquitination;Vertebral column

PROJECT_TITLE: Understanding post translational modifiers in DNA damage repair

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Narrative Fundamental features of Campylobacter jejuni host-association, such as mechanisms underlying its expansion in the gut lumen during infection, how gut metabolites influence this expansion, and how these metabolites impact expression of fitness traits during disease, are not well understood. Building off solid preliminary data using the ferret as a natural disease model, our proposed work will explore how C. jejuni alters gut physiology during acute infection, and how host derived lactate influences C. jejuni expansion and other traits associated with pathogenicity. The proposed work will provide important new knowledge of C. jejuni infection and guide us in developing new therapeutic targets against emerging multidrug-resistant strains.

PI_NAMEs: DIRITA, VICTOR J. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Abdominal Cramps;Acidity;Acquired Immunodeficiency Syndrome;Acute;acute infection;Adherence;Aerobic;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Biology;burden of illness;Campylobacter infection;Campylobacter jejuni;Cell Proliferation;Cells;Cessation of life;Chemotaxis;Citrobacter rodentium;Colon;colonic crypt;common symptom;Data;Developing Countries;Diarrhea;Disease;disease model;Disease Progression;Drug-resistant Campylobacter;Enteral;Environment;Epithelium;Euthanasia;Ferrets;Fever;fitness;foodborne;foodborne illness;Gastroenteritis;gastrointestinal;Growth;gut microbiota;Human;Hyperplasia;hypogammaglobulinemia;Immune system;Immunocompromised Host;in vivo;Incidence;Infection;infection rate;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-10;Intestinal Motility;Invaded;Knowledge;Lactate Dehydrogenase;Lamina Propria;Life;Mediating;Metabolism;metabolomics;Microbe;Modeling;Molecular;Motility;mouse model;Multi-Drug Resistance;new therapeutic target;NF-kappa B;Oral;pathogen;pathogenic bacteria;Pathogenicity;Pathogenicity Island;Physiology;Population;Preparation;Production;Proliferating;resistant strain;response;Role;Salmonella;Salmonella typhimurium;Shigella;Solid;Source;Stomach;Surface;Symptoms;System;Testing;Therapeutic;tissue repair;Tissues;Toxin;trait;transcriptomics;Undifferentiated;United States;uptake;Vibrio;Virulence;Vomiting;Work

PROJECT_TITLE: Role of the gut metabolite lactate on Campylobacter jejuni pathogenicity

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: The goal of this grant will be to create accurate, current national prevalence and incidence measurements of diabetic retinal disease. Furthermore, understanding the trajectory of the disease, particularly differences between racial and ethnic minorities, will allow for more effective policy creation.

PI_NAMEs: VANDERBEEK, BRIAN L. (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 20 year old;Adult;Affect;African American population;Age;Agreement;analog;Anti-diabetic Drugs;Arizona;Asian;Asian Americans;Black race;Blindness;Blood Glucose;Caring;Centers for Disease Control and Prevention (U.S.);Chinese American;cohort;Complications of Diabetes Mellitus;Consensus;cost;Country;Data;Databases;Development;diabetes control;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Disease;disease disparity;Disease Progression;Disparity;Effectiveness;epidemiology study;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;Eye;Eye diseases;Fright;Future;Goals;Government Agencies;Grant;Hispanic Populations;improved;Incidence;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Maryland;Measurement;Measures;Medical;Methods;Minority;Monitor;National Eye Institute;Non-Insulin-Dependent Diabetes Mellitus;Patients;Persons;Pharmaceutical Preparations;Physiological;Policies;Population Study;Populations at Risk;Prevalence;Provider;Public Health;Publishing;Race;racial disparity;racial minority;racial population;Retinal Diseases;screening;Sentinel;Severities;Severity of illness;Societies;Source;System;Therapeutic;therapy design;Time;Time trend;tool;trend;Update;Wisconsin

PROJECT_TITLE: Trends in US Rates of Diabetic Retinal Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (02)]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: This proposed project will develop a novel pulse oximetry technique that can noninvasively monitor the arterial blood oxygen saturation of the fetus during labor and delivery. It will provide obstetricians specific indicator of the necessity of emergency C-section. This project will improve the outcomes of childbirth and reduce the associated cost.

PI_NAMEs: YANG, WEIJIAN  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Abdomen;Adopted;Algorithms;Amniotic Sac;aspirate;Blood;Blood flow;Blood gas;Brain Injuries;Breathing;Cardiac;Cardiotocography;Cervix Uteri;Cesarean section;Childbirth;cost;Custom;Detection;detector;Early identification;Effectiveness;Emergency Situation;ewe model;experimental study;Face;Family;fetal;Fetal Monitoring;Fetal Tissues;Fetus;fetus at risk;fetus hypoxia;Fiber;Frequencies;Health;health of the mother;Hemoglobin;high risk;Hypoxia;improved;improved outcome;innovation;intrapartum;Lasers;Light;Machine Learning;machine learning algorithm;Measurement;Measures;Membrane;Methods;Monitor;Mothers;Near-Infrared Spectroscopy;Noise;non-invasive monitor;novel;operation;Optics;Outcome;Oxygen;Oxygen saturation measurement;Penetration;Performance;Photons;Physiologic pulse;Physiology;Play;Pregnancy;Pregnant sheep;Publishing;Pulse Oximetry;Risk;Role;Rupture;Safety;side effect;signal processing;Signal Transduction;Source;success;System;Techniques;Testing;Time;time use;tissue phantom;Tissues;Vagina;Vaginal delivery procedure;World Health Organization

PROJECT_TITLE: Interferometric near-infrared spectroscopy for transabdominal fetal oximetry

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Down syndrome is a chromosomal abnormality that is associated with disproportionate deficits in hippocampally-dependent memory (Godfrey & Lee, 2018; Pennington et al., 2003), resulting in a particular difficulty remembering specific details from past events. In addition to making it difficult for individuals with Down syndrome to access and share their past, this overgeneral memory can interfere with mental health (Waters 2014; King et al., 2019; Latorre et al., 2013) and independence (Holland et al., 2016; Sheldon et al., 2011). In the current project, the investigators examine the efficacy of a user-friendly and evidence-based (Martin et al., 2022) behavioral intervention—HippoCamera—in enhancing memory specificity in this population.

PI_NAMEs: FORD, JACLYN HENNESSEY (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Algorithms;Alzheimer's Disease;Amnesia;Anxiety;arm;Autobiography;Behavior Therapy;Behavioral Research;Boston;caregiver education;Child;Chromosome abnormality;Clinic;Cognitive;cognitive neuroscience;Cognitive Science;Collection;college;Development;Developmental Delay Disorders;digital;Down's Syndrome;Early Onset Alzheimer Disease;Educational workshop;efficacy evaluation;efficacy testing;Event;evidence base;experience;Focus Groups;follow-up;Functional disorder;General Hospitals;Genetic;Hippocampus;Human;Impaired cognition;Impairment;improved;Individual;Intellectual functioning disability;Intervention;life span;Manuals;Massachusetts;Measures;Medical Research;member;Memory;memory consolidation;Memory impairment;memory process;Mental Depression;Mental Health;mild cognitive impairment;Monitor;Moods;Neurosciences;older adult;Participant;Pattern;Personal Satisfaction;Play;Population;post intervention;Prevalence;Prosthesis;Psychology;Quality of life;Research;Research Personnel;Role;Sampling;smartphone application;Social isolation;Specificity;Testing;Time;Training;treatment arm;Universities;user-friendly;Water;Work

PROJECT_TITLE: Use of a digital memory prosthetic to support autobiographical memory in down syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative This application examines the basic premise that people reporting perceived discrimination in their late 20s are at higher risk for Alzheimer's Disease and Related Dementias in their later years. It also addresses the kinds of discrimination reported, and whether different groups of people are at greater or lesser risk.

PI_NAMEs: CHAPMAN, BENJAMIN P (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Accounting;Achievement;Address;Affect;Age;age-related disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Belief;Cessation of life;Characteristics;Chronic;Chronic stress;classification trees;Code;cognitive function;cognitive reserve;cohort;Complex;cost estimate;Data;Dementia;Demographic Factors;demographics;Development;Diagnosis;Discrimination;disease classification;disorder risk;emerging adulthood;Event;experience;follow-up;Follow-Up Studies;Gender;Goals;Health;Health behavior;high risk;High School Student;Impaired cognition;improved;indexing;Individual;interest;late life;Life Cycle Stages;Life Stress;Link;Literature;Longterm Follow-up;Measures;Memory;Methods;Modeling;Modernization;mortality;novel;Occupational;older adult;Outcome;Participant;Pathway interactions;perceived discrimination;Perception;Persons;Physiological;Population;Probability Samples;Procedures;Process;Race;regression trees;Reporting;Research Personnel;Risk;Risk Factors;Role;Sampling;Schools;social;social determinants;Stress;Subgroup;Talents;Testing;trend;United States Centers for Medicare and Medicaid Services;Update;Validation;Variant;Work

PROJECT_TITLE: Later Life Dementia: Links with General and Specific Discrimination in Emerging Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-R (90)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative The arenavirus Lujo virus emerged in Southern Africa in 2008, resulting in a human-to-human transmission chain and deaths of four out of the five infected. Here, we will structurally characterize the surface glycoprotein of Lujo virus alone and in complex with its cellular receptor, and will discover novel antibodies targeting this critical antigen. This work will illuminate the overall architecture and receptor-binding mode of this divergent arenavirus and provide much-needed therapeutic leads and research reagents.

PI_NAMEs: HASTIE, KATHRYN MARIE (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Africa;African;Amino Acid Sequence;Antibodies;Antigens;Apical;Architecture;Arenavirus;Arenavirus Infections;Argentinian Hemorrhagic Fever;Automobile Driving;Binding;Binding Sites;Biochemical;biophysical techniques;Bolivian Hemorrhagic Fever;Bolivian Hemorrhagic Fever Virus;Case Fatality Rates;Cell Surface Receptors;Cell-Matrix Junction;Cells;Cessation of life;Chemistry;Complex;Cryoelectron Microscopy;design;Disease Outbreaks;Distant;emerging pathogen;emerging virus;Endosomes;Engineering;Epitopes;Exposure to;Family;FDA approved;Future;Genetic;Genomics;Geographic Distribution;Geography;glycoprotein structure;Glycoproteins;GP2 gene;GTPBP1 gene;Health;Human;Immunize;In Vitro;Infection;innovation;Junin virus;Lassa Fever;Lassa virus;light scattering;Location;Lujo virus;Lymphocytic choriomeningitis virus;Mediating;Medical;member;Membrane;Membrane Fusion;Membrane Glycoproteins;Modeling;Molecular Conformation;monomer;Mus;Neuropilin-2;neutralizing antibody;novel;Old World Arenaviruses;pathogen;Pathogenicity;Pattern;Peptide Signal Sequences;Phylogenetic Analysis;prevent;Proteins;Reagent;receptor;receptor binding;Research;Rodent;Seasons;South American;Southern Africa;Structure;Surface;Surface Plasmon Resonance;Tacaribe Complex Viruses;Testing;TFRC gene;Therapeutic;therapeutically effective;transmission process;Tropism;Vaccine Design;vaccine development;Vaccines;Viral;Viral Hemorrhagic Fevers;Virus;Work;Zoonoses

PROJECT_TITLE: Illuminating Lujo virus glycoprotein structure, receptor engagement and neutralizing antibody epitopes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]