ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  The research proposed in this application consists of a rigorous crossover study to determine whether glucocorticoid receptor antagonism attenuates behavioral and neuroendocrinological responses to experimentally induced stress in non-treatment-seeking patients with alcohol use disorder (AUD), the pharmacodynamic effects of alcohol (ALC), and drinking, craving and stress in the natural environment. The proposed study is innovative and important because it might spur the development of PT150 as an adjunct therapy for alcohol use disorder.

PI_NAMEs: FILLMORE, MARK T (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Adrenal Glands;Affinity;Alcohol consumption;alcohol demand;alcohol effect;alcohol measurement;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;antagonist;Area;Attenuated;attenuation;Auditory;Behavior assessment;behavior prediction;Behavioral;Bilateral;biological adaptation to stress;Biological Availability;Blood;Blood Pressure;Businesses;Clinical;Clinical Pharmacology;Clinical Research;Cognitive;comparison control;conditioned place preference;Consumption;Corticosterone;craving;Cross-Over Studies;Development;Dose;drinking;Ecology;electronic data;Environment;Feedback;Female;foot;Glucocorticoid Receptor;Glucocorticoids;Goals;Heart Rate;Heavy Drinking;Hormones;Human;human subject;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;improved;innovation;interest;Kentucky;Literature;Maintenance;male;Mammals;Memory;Mifepristone;Moods;negative mood;Neuroendocrinology;Neurosciences;Neurosciences Research;Neurosecretory Systems;Oncology;opioid use disorder;Oral;Participant;Patients;Performance;Pharmacodynamics;Pharmacology Study;Pharmacotherapy;Physiological;Pituitary Gland;Placebos;pre-clinical;pre-clinical research;preclinical study;Progesterone Receptors;prolonged abstinence;Public Health;Questionnaires;reduced alcohol use;Relapse;Reporting;Research;Research Personnel;Research Support;response;Rights;Role;Self Administration;Severities;social;stimulant use disorder;Stress;stressor;Substance Use Disorder;Surveys;System;Testing;Therapeutic;Tobacco Use Disorder;tool;Translating;Universities;Withdrawal;Work

PROJECT_TITLE: Selective Glucocorticoid Receptor Antagonism in Alcohol Use Disorder: A Human Neuroscience Study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Autonomous programs of cell death are targetable vulnerabilities for cancer treatment. However, most programs of cell death are poorly understood and only active in specific contexts suggesting additional fruitful areas for cancer drug target discovery exist. In our project, we have identified a novel cell death mechanism controlled by the p53 tumor suppressor in small cell lung cancer that we aim to functionally characterize and develop strategies to exploit for therapeutic gain.

PI_NAMEs: FELDSER, DAVID  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;Area;Autophagocytosis;Biological Models;Cancer cell line;cancer initiation;Cancer Model;Cancer Patient;cancer therapy;Cell Death;Cell Death Induction;Cell membrane;cell type;Cells;Cessation of life;cis trans isomerization;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;comparative genomics;Complex;CRISPR screen;Cyclophilins;Cyclosporine;Cytoplasm;D Cells;Data;design;Development;driver mutation;Drug Targeting;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelial Cells;experimental study;Family member;Functional disorder;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;genomic data;Human;In Vitro;in vivo Model;innovation;insight;Laboratories;Link;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;Membrane;Modeling;Molecular;molecular subtypes;mouse model;Mus;novel;Outcome;Output;Pathway interactions;Peptidylprolyl Isomerase;Phenotype;Physiological;Play;Population;Predisposition;programs;Proline;Protein Family;Proteins;Regulation;Rest;restoration;RNA Splicing;Role;Rupture;Scientist;senescence;Signal Transduction;small cell lung carcinoma;small molecule inhibitor;Specificity;Stimulus;Swelling;Testing;Therapeutic;tool;TP53 gene;Transcriptional Activation;Transcriptional Regulation;tumor;Tumor Suppression;ubiquitin-protein ligase;Vacuole;Variant

PROJECT_TITLE: Context dependent tumor suppression

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: It is important to develop and implement more effective interventions for improving long-term weight loss. There is some evidence that mind-body interventions, specifically yoga, have the potential to contribute to improved weight loss; however, these interventions have not been extensively studied within the context of a comprehensive behavioral weight loss intervention. This study proposes to implement a novel intervention that combines yoga with a behavioral weight loss intervention to examine its effectiveness on potentially enhancing weight loss and other health outcomes in adults with overweight or obesity.

PI_NAMEs: JAKICIC, JOHN M (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Acute;Adult;adult obesity;Advisory Committees;Aerobic;Affect;Behavioral;Blood Pressure;Body Composition;Body mass index;Body Weight Changes;Body Weight decreased;cardiorespiratory fitness;Chronic;Chronic Disease;Clinical Trials Design;Data;depressive symptoms;Diet;dietary approach;Distress;Eating;Eating Behavior;effective intervention;Effectiveness;Eligibility Determination;Energy Metabolism;Ethnic Origin;evidence base;Exercise;fitness;Focus Groups;Guidelines;Health;Health Benefit;high standard;Hunger;improved;Intervention;light intensity;Measures;Mental Depression;Mental Health;Methodology;Mind-Body Intervention;mindfulness;moderate-to-vigorous physical activity;Moods;Muscle;novel;obese patients;Obesity;Outcome;Overweight;Participant;Patients;Pattern;perceived stress;Physical activity;Pilot Projects;primary outcome;Process Measure;progression risk;psychologic;Public Health;Race;Randomized;randomized trial;randomized, clinical trials;Recommendation;Reducing diet;Reporting;Research;Research Design;response;Rest;Safety;Satiation;Science;secondary outcome;sedentary lifestyle;sex;Sleep;Stress;systematic review;trial design;vigorous intensity;Walking;weight loss intervention;Work;Yoga

PROJECT_TITLE: Effectiveness of the Addition of Yoga to a Behavioral Weight Loss Intervention for Adults with Overweight or Obesity

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Unique characteristics and service experiences of Veterans place them at an increased risk for sustained alcohol misuse. This excessive alcohol consumption positively correlates with hepatic disorders, including alcoholic hepatitis, a clinically challenging spectrum of alcohol-associated liver disease (ALD). Here, we propose to identify the mechanism by which alcohol consumption disrupts gut barrier integrity and gut dysbiosis to promote endotoxemia and the subsequent development of alcoholic hepatitis. Our project also seeks to identify the therapeutic benefit of administering betaine, a safe, bioavailable, highly soluble, and naturally occurring compound, in maintaining the integrity of the intestinal barrier, preserving the gut microbiome, and preventing liver inflammation. We hope this treatment option will ultimately prevent ALD progression and lessen the economic burden to the VA health care system.

PI_NAMEs: KHARBANDA, KUSUM K. (contact)

PROJECT_TERMS: Acetaldehyde;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Antigens;Apical;arm;Attenuated;Betaine;Biological Availability;Cell Wall;Characteristics;Circulation;Clinical;clinically relevant;cofactor;Complex;Development;Disease Progression;dysbiosis;Economic Burden;Endotoxemia;Endotoxins;Epithelial Cells;Ethanol;Event;experience;Extravasation;FDA approved;Financial Hardship;Functional disorder;fungus;gastrointestinal epithelium;Generations;Gram-Negative Bacteria;gut dysbiosis;gut microbiome;gut microbiota;gut-liver axis;Healthcare Systems;Heavy Drinking;Hepatic;hepatocyte injury;Impairment;In Vitro;in vivo;indexing;Inflammation;insight;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Liver;Liver diseases;liver inflammation;liver injury;Mediator;Metabolic Pathway;Methionine;methyl group;Methylation;Methyltransferase;microbial;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Mus;Natural Compound;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Patients;Penetration;polyglucosan;preservation;prevent;Preventive;Production;Proteins;Proteobacteria;Rattus;Reaction;Regimen;Regulation;repaired;Research Design;Risk;Role;Serum;Services;Severity of illness;Site;Supplementation;Testing;Therapeutic;Tight Junctions;Travel;treatment arm;United States;Veterans

PROJECT_TITLE: Gut-Liver Axis in the Pathogenesis of Alcohol-Associated Liver Disease: Protection by Betaine Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The proposed project will contribute fundamental knowledge about how state-level social policies that provide economic resources and supports for low-income and other socially disadvantaged groups of U.S. women during the childbearing years can intervene upon public health priority maternal mental health outcomes and disparities. Findings will cue policy makers to action and inform cross-sector “women’s health in all policies” approaches to reduce poverty, maternal morbidity and mortality, and promote maternal health equity across the reproductive life course and for generations of families.

PI_NAMEs: FRISVOLD, DAVID ERIC;HALL, KELLI STIDHAM (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: adverse outcome;Age;aged;Aid to Families with Dependent Children;behavioral outcome;Biological;Birth;burden of illness;child bearing;Child Care;Child Development;Child Rearing;Child Welfare;Collection;Communities;community advisory board;Complex;Conceptions;Cues;Data;Data Set;Dimensions;disability;Disadvantaged;Discrimination;disparities in women;Disparity;Disparity population;District of Columbia;early childbearing;economic outcome;Economic Policy;Economics;Eligibility Determination;Ensure;ethnic minority;Ethnic Origin;Evaluation Studies;evidence base;experience;Family;Family Leave;Financial Hardship;Food;Functional disorder;Funding;Generations;Goals;Health;health care availability;health equity;health organization;Health Promotion;Housing;improved;Income;Income Tax;Individual;Inequity;interest;intergenerational;Intervention;Investments;Knowledge;Laws;Legal;Length;Life Cycle Stages;Link;Low income;low socioeconomic status;Maps;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Measurement;Mediation;Medical;Mental Depression;Mental Health;Mental health promotion;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;Nature;novel;Outcome;Pattern;Perinatal;Personal Satisfaction;Persons;Policies;Policy Maker;Population;Postpartum Period;Poverty;poverty reduction;Pregnancy;Pregnancy Outcome;prenatal;prevent;psychologic;psychosocial outcome;Public Health;public health intervention;public health priorities;Public Policy;Quasi-experiment;Race;racial minority;Recording of previous events;reproductive;Research;Resources;Risk;Role;Rural;rurality;Security;Shapes;Social Conditions;social disparities;Social Mobility;Social Policies;Social Protection;social stress;social stressor;sociodemographics;Socioeconomic Status;Stress;surveillance study;Testing;Time;underserved area;United States;United States National Institutes of Health;urban residence;Urbanicity;Variant;Vision;Wages;Woman;women of color;Women's Group;Women's Health

PROJECT_TITLE: State social policy interventions for maternal health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Glaucoma is a leading cause of vision loss, impacting an estimated 80 million individuals worldwide and incurring an annual healthcare cost of $6-8 billion. Lowering intraocular pressure is crucial for preventing and slowing the progression of glaucoma, but monitoring it continuously, especially during sleep, presents a challenge. This proposal aims to develop and optimize a unique platform of smart soft contact lenses that can provide continuous, 24-hour monitoring of intraocular pressure, prioritizing safety and high tolerance among the majority of glaucoma patients and those suspected to have the condition.

PI_NAMEs: BOUDOURIS, BRYAN WILLIAM;KOLLBAUM, PETE S;LEE, CHI HWAN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Adoption;Affect;Age related macular degeneration;arm;Awareness;Binding;biomaterial compatibility;Blindness;bodily sensation;Calibration;Canis familiaris;Caring;Cataract;Cell Survival;Cells;Chemicals;Chronic;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;comparison control;Contralateral;Cornea;corneal epithelium;Defect;Dehydration;design;Devices;Diagnosis;Disease;Early Diagnosis;Effectiveness;Enrollment;Ensure;Erythema;Euthanasia;Evaluation;Eye;Eye diseases;Family suidae;Feedback;Foreign Bodies;Future;Glaucoma;Health Care Costs;Heating;Home;Hour;Human;Hydrophilic Contact Lenses;improved;In Vitro;in vivo;in vivo evaluation;Individual;integrated circuit;Keratitis;Latanoprost;lens;Longevity;Measurement;mechanical load;Methods;Monitor;ocular pain;Optic Nerve;Outcome;Oxygen;Pain;Participant;patient home care;patient oriented;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Physiologic Intraocular Pressure;portability;prevent;Primary Open Angle Glaucoma;Property;Protocols documentation;prototype;Reproducibility;Risk;Safety;Seasons;Series;side effect;Sleep;Stretching;Structure;success;Supine Position;Testing;Theft;tonometry;Vision;Visual Fields;wearable device;Wettability

PROJECT_TITLE: Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Contraception/Reproduction;Dietary Supplements;Genetics;Infertility;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Male factor infertility is responsible in as much as 50% of cases of couple infertility, and has been observed to represent an early life predictor of later life disease risk. Conventional semen parameter analysis remains the most prevalent diagnostic tool for assessing male fertility, but semen parameters – as proxies for true biological measures of sperm function – poorly predict male infertility and reproductive success. This proposed research builds on exciting preliminary data suggesting sperm mitochondrial DNA as novel biomarkers that directly measure sperm fitness and holds promise to improve our understanding of the etiology of male reproductive health and take a critical step toward developing interventions for male sub- and infertility.

PI_NAMEs: PILSNER, J. RICHARD  (contact);WHITCOMB, BRIAN WILLIAM

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Affect;Assessment tool;Biological;Biological Markers;Biology;Caring;Characteristics;Classification;Clinical;clinical care;Clinical Data;clinical predictive model;cohort;Complex;Conceptions;Couples;Data;Development;Diagnosis;diagnostic tool;Dimensions;disorder risk;DNA copy number;DNA Markers;Epigenetic Process;Etiology;Fertilization;Fertilization in Vitro;fitness;flexibility;folic acid supplementation;Funding;General Population;Genome;improved;Individual;Infertility;infertility treatment;innovation;insight;Intervention;intrauterine insemination;late life;Life;Live Birth;Machine Learning;male;male fertility;Male Infertility;Measures;Mitochondria;Mitochondrial DNA;Modeling;novel;novel marker;Outcome;Participant;Pathway interactions;Patients;Physiological Processes;Play;Predisposition;Pregnancy;Probability;Proxy;Public Health;Publishing;Recommendation;Reproduction;reproductive;Reproductive Health;reproductive outcome;reproductive success;Research;Resources;Sampling;Sampling Studies;Seminal fluid;sperm cell;sperm function;Spermiogenesis;Statistical Methods;success;Testing;Time;time-to-pregnancy;Treatment outcome;United States National Institutes of Health;Work;World Health Organization;Zinc supplementation

PROJECT_TITLE: Sperm mitochondrial biomarkers and male reproductive health

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Anti-seizure medications are commonly prescribed to suppress seizures and seizure-like epileptiform electrical activity of the brain detected by electroencephalography (EEG) in patients with acute brain injury. While suppressing epileptiform electrical activity of the brain may minimize its harmful effects, anti-seizure medications have significant adverse effects and there is limited to no evidence on the risks vs. benefits of treatment. This project will use observational data from a multi-center EEG dataset of 46,000 patients to determine whether treatment of epileptiform electrical activity with anti-seizure medications improves mortality and functional outcomes, and to provide high quality evidence to guide clinical decisions in patients with acute brain injuries.

PI_NAMEs: ZAFAR, SAHAR F (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute Brain Injuries;acute care;Address;Adverse effects;Age;Anesthetics;Anticonvulsants;Biological;brain electrical activity;Brain Injuries;Brain region;Caring;Cause of Death;Cessation of life;Characteristics;Clinical;clinical care;Clinical Trials;Community Hospitals;comparative effectiveness;comparative effectiveness study;Complex;cost;Critical Care;Critical Illness;Data;data registry;Data Set;Death Records;design;Development;disability;disorder subtype;Dose;Drug Kinetics;Electroencephalography;Electronics;Epilepsy;epileptiform;experimental study;Exposure to;Frequencies;Functional disorder;Functional impairment;functional outcomes;Future;high risk;Impaired cognition;improved;improved outcome;Individual;Injury;insight;Israel;Knowledge;Learning;Libraries;Link;Long term disability;Machine Learning;Managed Care;Medical center;Metabolic;Metabolism;Methodology;Methods;Modeling;Modernization;Monitor;mortality;mortality risk;Natural History;Nature;Neurological outcome;neurophysiology;novel;Observational Study;optimal treatments;Organ;Outcome;Pathologic;Patient Admission;patient population;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacoepidemiology;pharmacokinetics and pharmacodynamics;Population Heterogeneity;Positioning Attribute;Practice Management;primary outcome;Psychological reinforcement;Randomized;randomized trial;Randomized, Controlled Trials;Records;recruit;Recurrence;Registries;Rehabilitation therapy;response;Risk;risk mitigation;Sample Size;secondary outcome;Sedation procedure;Seizures;Severities;Severity of illness;sex;side effect;simulation;Statistical Models;Stroke;System;Testing;Time;tool;Trauma;treatment effect;treatment strategy;trial design;Variant;Work

PROJECT_TITLE: Comparative effectiveness of EEG-guided anti-seizure treatment in acute brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative  At present there exists a disconnect between the emerging diversity in interneuron cell types and its functional impact on cortical circuit organization. In the present grant we aim to demonstrate that there exists a presently unbeknownst selectivity of SST cINs for pyramidal and interneuron populations, such that cortical circuits are comprised of lock and key connections between specific subtypes. My proposal by coupling our expertise in studying the development of cortical interneurons, transcriptomics and both anatomical and optogenetic circuit cracking, promises to bridge this gap.

PI_NAMEs: FISHELL, GORDON J (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Anatomy;Back;Brain Diseases;Candidate Disease Gene;cell cortex;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupling;Data;Date of birth;Development;Developmental Process;Disease;DNA;Embryo;Embryonic Development;Event;excitatory neuron;Generations;Genes;Genetic;genetic approach;Genetic Engineering;Goals;Grant;hippocampal pyramidal neuron;Individual;inhibitory neuron;insight;interdisciplinary approach;Interneurons;Label;Laboratories;Maps;Molecular;Molecular Biology;Motor;Neurons;optogenetics;Peripheral;Physiology;Population;postnatal period;Process;programs;Property;prototype;Pyramidal Cells;Route;Sensory;Shapes;Signal Transduction;skills;Somatostatin;Specificity;Stereotyping;Structure;Synapses;synaptogenesis;Testing;transcriptomics;Viral;Visualization;Work

PROJECT_TITLE: The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Methods for sequencing newly transcribed RNA molecules, or “nascent” RNAs, have become widely used in the study of transcription, with broad implications for both basic biology and human disease. However, these methods produce complex data sets that are challenging to analyze, and limited software for analysis is available to the scientific community. We propose to develop a powerful new statistical and machine-learning framework, and a well-engineered open-source software implementation, that together will enable a wide variety of new and improved analyses of nascent RNA sequencing data.

PI_NAMEs: SIEPEL, ADAM CHARLES (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Address;Bar Codes;Bioconductor;Biology;Caring;cell type;Classification;Cloud Computing;Communities;comparative genomics;complex data;computational platform;Computer software;computerized tools;Computing Methodologies;Coupled;Data;Data Collection;Data Set;Dependence;Development;DNA;DNA Sequence;DNA-Directed RNA Polymerase;Documentation;Engineering;Environment;epigenomics;Family;flexibility;Generations;generative models;Genetic Transcription;Genome;Genomics;human disease;improved;innovation;Kinetics;Life;machine learning framework;machine learning method;Malignant Neoplasms;mathematical model;Measures;Methods;Modeling;National Human Genome Research Institute;neural network;novel;open source;Organism;Polymerase;Positioning Attribute;Process;promoter;Research;RNA;RNA Degradation;Sampling;Series;signal processing;simulation;Software Engineering;statistical learning;Statistical Methods;Statistical Models;Techniques;temporal measurement;Testing;Time;tool;Transcript;Transcription Elongation;Transcription Initiation;transcriptome;transcriptome sequencing;Variant

PROJECT_TITLE: A unified probabilistic model and software implementation for analysis of nascent RNA sequencing data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: FARMINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Stroke is a leading cause of death and disability worldwide but without effective therapy. We propose that the oxidative stress activated Ca2+-permeable TRPM2 orchestrates ischemia injury cascade by integrating multiple signaling pathways and various cell types at both local as well as systemic levels, and that TRPM2 can be an effective therapeutic target for ischemic stroke. We will use multidisciplinary approaches to delineate the mechanisms by which TRPM2 mediates ischemia injury, and how TRPM2 can be a multimodal target of a holistic therapeutic approach, and our results will provide novel insights into the role of TRPM2 in ischemic brain stroke and may ultimately prove that it is a better target for treatment of ischemic brain stroke.

PI_NAMEs: YUE, LIXIA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Alteplase;Animal Model;Animals;Atherosclerosis;bench to bedside;Brain;Brain Ischemia;Cause of Death;Cell Physiology;cell type;Cells;Clinical;clinical practice;Clinical Trials;clinically relevant;comorbidity;Complex;Couples;cytokine;Data;design;disability;effective therapy;Endothelial Cells;excitotoxicity;Exhibits;Failure;FDA approved;Functional disorder;Future;Goals;holistic approach;Hyperlipidemia;improved;Injury;innovation;insight;interdisciplinary approach;Investigation;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;Knock-out;Knowledge;Macrophage;Mediating;multimodality;neural circuit;Neurons;novel;novel therapeutics;Outcome;Oxidative Stress;Pathology;Patients;Permeability;Pharmaceutical Preparations;Play;pre-clinical;pre-clinical research;protective effect;receptor;Research;Role;Signal Pathway;Stroke;stroke model;stroke patient;stroke therapy;systemic inflammatory response;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy outcome;Translating;Translations

PROJECT_TITLE: Transient Receptor Potential Melastatin 2 (TRPM2) in Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Genetics;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE This proposal aims to elucidate fundamental mechanisms by which control of fat metabolism is regulated during host-bacteria conflict through alternative splicing and expression of lipases that control endocannabinoid production and immune responses. The proteins and processes being investigated here are conserved in humans so the study will potentially open up avenues for non-antibiotic-based therapeutics for treatment of bacterial infections and inflammatory diseases. Hence, this project is highly relevant for human health and fits the NIH mandate of unraveling fundamental knowledge that will help reduce the burden of human disease.

PI_NAMEs: GHAZI, ARJUMAND  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2-arachidonylglycerol;Acid Lipase;Alternative Splicing;Animals;Bacteria;Bacterial Infections;Biogenesis;Blood Cells;Caenorhabditis elegans;Caenorhabditis elegans Proteins;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Conflict (Psychology);Data;differential expression;Diglycerides;Disease;Endocannabinoids;Energy-Generating Resources;Enteral;Enzymes;Exclusion;Exhibits;Exons;Family;Fatty acid glycerol esters;gene conservation;Gene Expression;Gene Expression Regulation;Gene Family;Genes;genetic analysis;genetic approach;Health;Homologous Gene;Host Defense;host-microbe interactions;Human;human disease;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;Immunologic Factors;immunological status;immunoregulation;in vivo;in vivo Model;Infection;infectious disease treatment;Inflammatory;Intestines;Knowledge;Link;Lipase;lipid metabolism;Lipid Mobilization;lipidomics;Lipids;Longevity;Mammalian Cell;Mammals;Mediating;member;Messenger RNA;Metabolic;microbiota;Modeling;Molecular;Molecular Genetics;mRNA Precursor;mutant;novel;opportunistic pathogen;Outcome;pathogen;Pathology;Pathway interactions;Phospholipase;Physiological;posttranscriptional;Process;Production;protein function;Protein Isoforms;Proteins;Pseudomonas aeruginosa;Regulation;Repression;Resistance;RNA Splicing;Role;Shapes;Signaling Molecule;spatiotemporal;System;targeted treatment;Testing;Therapeutic;Transcription Repressor;Transcriptional Regulation;Triglycerides;United States National Institutes of Health;Work

PROJECT_TITLE: Alternative Splicing & Differential Expression of Lipases in Host-Microbe Interactions

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE A hypothesis driven program tests how brain tumors, and the surgeries to remove them, affect neural representational spaces for objects and actions across a distributed brain network, and whether resilience to post-operative behavioral deficit is associated with representations shifting to the non-operative hemisphere.

PI_NAMEs: HADJIPANAYIS, CONSTANTINOS GEORGE;MAHON, BRADFORD ZACK (contact);PILCHER, WEBSTER H

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Anatomy;Animals;Anterior;Area;behavior test;Behavioral;behavioral impairment;behavioral outcome;Brain;Brain Injuries;Brain Neoplasms;Brain region;Categories;Clinical;clinically relevant;Complex;Cues;Dependence;Distal;Distant;Environment;Exhibits;Face;Fingers;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Goals;grasp;Hand;Image;induced pluripotent stem cell;information processing;Injury;innovation;Knowledge;Lateral;Left;Lesion;Life;Literature;Location;Maintenance;Maps;Measures;Medial;Medical center;Modeling;monocular;Motor;Motor Cortex;Movement;neural;Neurocognitive;neuroprosthesis;Neuropsychology;object shape;Occipital lobe;Operative Surgical Procedures;Outcome;Parietal;Parietal Lobe;Participant;Pathway interactions;Patient Recruitments;Patients;Pattern;Postoperative Period;Posture;predictive test;preference;programs;Recovery;Research;resilience;response;Robotics;Role;Shapes;Site;skills;Structure;Structure of superior temporal sulcus;Structure of supramarginal gyrus;Surface;Surgical incisions;synergism;Temporal Lobe;Testing;Tissues;tool;tumor;vector;visual information;visual object processing;visual stimulus;Vocabulary;white matter;Work;Wrist

PROJECT_TITLE: Representational Similarity Spaces for Objects and Actions Before and After Brain Tumor Surgery

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Older Korean Americans, like other ethnic minority and immigrant older adults in the United States, are largely unserved by existing hearing care models. Community health worker-partnered models of hearing care that leverage over-the-counter hearing care and build local capacity, such as through faith-based organizations, are new, critical, and relevant to meeting the hearing care needs of rapidly increasing ethnic minority older adults such as Korean Americans. This first-in-kind, multidisciplinary proposal will build the evidence for a community health worker-partnered model of hearing care specifically designed for older adults and their communication partners with significant language and cultural barriers, strengthening a community-based model of hearing care that will benefit resource-poor ethnic minority older adults and their communication partners more broadly.

PI_NAMEs: HAN, HAE-RA ;NIEMAN, CARRIE L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Aging;aging population;arm;Asian;Asian Americans;Audiology;Bilateral;bilingualism;Caring;Church;Clinic;Cluster randomized trial;cognitive function;Collaborations;Communication;Communities;community engaged research;Community Health;Community Health Aides;community partners;cost;cost effective;design;disability;Discipline of Nursing;Disparity;Dissemination and Implementation;efficacy trial;Elderly;Equipment and supply inventories;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;experience;Face;Faith-based organization;Family;Family member;Friends;Frustration;future implementation;Generations;Gerontology;Health;Health behavior;health disparity;health equity;Health Promotion;health related quality of life;Health Services Accessibility;healthy aging;Hearing;Hearing Aids;hearing impairment;Hispanic;Immigrant;Immigrant community;improved;Interdisciplinary Study;Intervention;intervention delivery;Korean American;Language;Limited English Proficiency;loved ones;low health literacy;Low income;Marketing;Measures;Medicare;meetings;Modeling;multidisciplinary;Not Hispanic or Latino;older adult;Otolaryngology;Partner Communications;peer;Physical Function;Pilot Projects;Population;post intervention;Poverty;Prevalence;Public Health;public health priorities;Public Housing;Race;racial minority;racial population;Randomized, Controlled Trials;rapid growth;Religion;Research;Research Personnel;Resources;Risk;Role;Sampling;screening;social;Social Functioning;social stigma;Socioeconomic Status;Technology;Testing;theories;therapy design;treatment group;Uninsured Medical Expense;United States;United States National Institutes of Health;Vulnerable Populations;Withdrawal

PROJECT_TITLE: K-HEARS: Hearing Health Equity through Accessible Research and Solutions for Korean Americans

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Contraception/Reproduction;Genetics;Infertility;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative: While animal embryos receive approximately equal amounts of DNA from each of their parents, nearly all of their cytoplasm is inherited from the female gamete. This cytoplasm contains information in the form of maternal proteins and mRNAs that are used by the embryo prior to “zygotic gene activation”, the point at which maternal mRNA is cleared and the embryo becomes reliant upon its own genome. We seek to understand how this maternal information is stored in the cytoplasm during oogenesis, then decoded after fertilization. We use C. elegans, a well-established genetically tractable invertebrate model organism, to study this process.

PI_NAMEs: RYDER, SEAN PATRICK (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 3' Untranslated Regions;Address;Adult;Affect;Animals;Bacteria;Buffers;Caenorhabditis elegans;cell fate specification;Cells;Child;climate change;Clinic;CRISPR/Cas technology;Cues;Cytoplasm;Data;defined contribution;Development;DNA;Double-Stranded RNA;Embryo;Embryonic Development;Ensure;Environment;environmental change;Environmental Risk Factor;Event;experimental study;Exposure to;Failure;feeding;Female;Fertility;Fertilization;Fishes;Food Chain;Gametogenesis;Gender;Gene Activation;Gene Deletion;Gene Expression;Gene Expression Regulation;gene replacement;Gene Targeting;Generations;Genes;Genetic Models;Genetic Screening;Genetic Transcription;Genome;genome editing;genome-wide;Genomics;Germ Cells;Germ Lines;Growth;Health;Heat Stress;High temperature of physical object;Hornets;Individual;Inherited;Instruction;interdisciplinary approach;interest;Invertebrates;Investigation;Laboratories;Learning;male;Mammals;Maps;Maternal Messenger RNA;Measures;Meiosis;Messenger RNA;model organism;Molecular;Molecular Genetics;mutant;Mutate;Mutation;Nematoda;notch protein;oocyte maturation;Oocytes;Oogenesis;Parents;Pathway interactions;Pattern;Pattern Formation;Phenotype;Physiological;Plants;Play;Positioning Attribute;Post-Transcriptional Regulation;Pregnancy;Process;Property;Proteins;Regulation;Reiterated Genes;Reporter;Reproduction;reproductive;Reproductive Biology;reproductive success;Reptiles;Risk;RNA;RNA Interference;RNA interference screen;RNA, Messenger, Stored;RNA-Binding Proteins;Role;sex determination;Sex Ratio;Sexual Reproduction;Sterility;Stress;success;Surveys;Temperature;Testing;Time;tool;Transcript;Translating;Translations;Turtles;Untranslated Regions;Urticaria;ventilation;Visualization;Wing;zygote

PROJECT_TITLE: Unmasking the role of maternal transcript UTRs in reproductive fecundity

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Public Health Relevance Statement  This project will studies a gene, CAVEOLIN1 that has been associated with a major blinding eye disease, glaucoma, and with the major risk factor for this disease, eye pressure. These current studies will define how this gene controls pressure in the eye and will also focus on the function of genetic variants that are linked to increased risk of developing glaucoma. The outcome of these studies will identify novel therapeutic mechanisms to lower eye pressure thereby reducing the risk of development and progression of glaucoma.

PI_NAMEs: ELLIOTT, MICHAEL H (contact);STAMER, W DANIEL

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Ablation;Actins;Address;Aqueous Humor;Biomechanics;Blindness;CAV1 gene;Caveolae;Cell Culture Techniques;cell type;Cells;Cytoskeleton;Defect;Development;Disease;Distal;Drainage procedure;Endothelium;Enhancers;Eye;Eye diseases;Feedback;Funding;Gene Expression;Gene Targeting;Genes;Genetic Polymorphism;Genetic Transcription;genetic variant;genome wide association study;Glaucoma;Goals;Homeostasis;Human;Immunoprecipitation;Impairment;In Vitro;in vivo;Link;LoxP-flanked allele;Maintenance;Mass Spectrum Analysis;Mechanical Stimulation;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Molecular;Morphology;mouse model;Mus;Normal Range;novel therapeutic intervention;novel therapeutics;Ocular Hypertension;Outcome Study;Pathology;Pathway interactions;Physiologic Intraocular Pressure;Play;pressure;Primary Open Angle Glaucoma;Process;programs;Proteins;Proteomics;public health relevance;Regulation;Reproducibility;Resistance;response;rho;Risk;Risk Factors;Risk Reduction;risk variant;Role;sensor;Signal Transduction;Structure of sinus venosus of sclera;Testing;Tissue-Specific Gene Expression;Tissues;Trabecular meshwork structure;translational genetics;Untranslated RNA;Variant;Vascular Endothelium;Vascular System;Work

PROJECT_TITLE: Caveolae-Based Mechanosensors for Conventional Outflow Regulation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Stigma is an important social determinant of health among stigmatized adults, yet previous research has not comprehensively tested the impact of multiple forms of stigma on blood pressure, a strong predictor of future cardiovascular disease and mortality. Findings from this study will provide the best evidence to date on mechanisms by which anticipated and vicarious stigma influence blood pressure. This study is a critical step for identifying mechanistic targets for future interventions and policies to reduce the adverse effects of stigma on cardiovascular disease risk in stigmatized adults.

PI_NAMEs: CACERES, BILLY A (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: actigraphy;Adult;Adverse effects;Affect;Affective;Age;alpha-amylase;Anxiety;Area;Behavior Therapy;Behavioral;Biological Markers;Black race;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cause of Death;Chronic;Collection;Data;Diagnosis;diaries;disability;Discrimination;Effectiveness;electronic structure;Electronics;Environment;ethnoracial;Event;Exclusion;expectation;experience;Exposure to;Face;Future;Goals;Guidelines;Health;health disparity;Hearing;High Prevalence;Home;Home Blood Pressure Monitoring;Hydrocortisone;Hypertension;Individual;Intervention;Interview;Lead;Lesbian;Lesbian Gay Bisexual;Link;Mediating;Mediator;Mental Depression;Modeling;modifiable risk;mortality;neglect;New York City;Outcome;Participant;people of color;perceived discrimination;Personality;Persons;Physiological;Policies;Population;Process;Race;racial identity;recruit;Reporting;Research;Research Personnel;Risk Reduction;saliva sample;Salivary;Sampling;sexual identity;sexual minority;Sleep;Sleep Disorders;social determinants;social health determinants;social stigma;Social support;socioeconomic disadvantage;Stigmatization;Stress;stressor;Structure;Testing;theories;therapy design;Tobacco use;United States;Woman;Work;Wrist

PROJECT_TITLE: A daily diary examination of the influence of intersectional stigma on blood pressure

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Pain Research;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will contribute to improved public health by helping understand if treating immune overactivity can decrease abnormal bone formation in patients with FOP. The new knowledge will validate important tools and approaches for clinical studies in small cohorts of patients, and also provide critical preliminary data for designing larger studies that may be beneficial for patients with common causes of abnormal bone formation.

PI_NAMEs: HSIAO, EDWARD C (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 18 year old;activin A;Acute;ACVR1 gene;Address;Adverse event;Aftercare;Age;aged;anakinra;Antigens;Artificial Intelligence;Assessment tool;automated segmentation;Biological Markers;Blood;Bone Morphogenetic Proteins;Caring;Case Study;Child;Childhood;Cicatrix;Clinical;Clinical Research;cohort;cytokine;Data;design;diaries;Disease;Disease Progression;Dose;Drug Prescriptions;effective therapy;Enrollment;Fibrosis;Flare;Frequencies;functional improvement;Future;Heterotopic Ossification;HMGB1 gene;Image;Immune;Immune system;improved;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;inhibitor;Insurance;Interleukin-1;Intervention;Intervention Studies;Knowledge;Lipopolysaccharides;Location;Macrophage;Manuals;Measurement;Measures;Medical;Methods;Monitor;Mutation;Normal tissue morphology;Observational Study;Osteogenesis;Outcome Assessment;Pain;pain scale;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;Population;portability;Process;Progressive Disease;progressive myositis ossificans;Public Health;Rare Diseases;Recommendation;remote monitoring;Reporting;response;Safety;Serum;Severities;Signal Transduction;Site Visit;Skin;Stimulus;Surface;Swelling;Systems Analysis;Temperature;Therapeutic;tissue repair;Tissues;tool;Trauma;Work;X-Ray Computed Tomography

PROJECT_TITLE: An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Narrative Worldwide, migraine headache is the most common neurological disorder and comes with great socioeconomic burden. Mast cells are a type of immune cell located in the thin covering of the brain, called the meninges, and have long been linked to migraine. In this proposal we plan on examining a receptor family, Mrgpr, specifically expressed on mast cells; and their role in linking neural and immune systems to migraine-induced pain.

PI_NAMEs: GREEN, DUSTIN PEPPER (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Ablation;Acute;Affect;Afferent Neurons;Agonist;Animal Model;Animals;Behavior;Brain;Cell Degranulation;Cells;Chemicals;chemokine;Clinical;cytokine;Data;Disease;Dura Mater;Economic Burden;experimental study;Face;Family;Fiber;Flow Cytometry;Functional disorder;G-Protein-Coupled Receptors;Homologous Gene;Human;Hypersensitivity;Image;imaging approach;imaging modality;Immune;Immune system;In Vitro;in vivo;in vivo imaging;Inflammatory;Injections;Knockout Mice;Knowledge;Link;Maintenance;mast cell;Mechanics;Mediator;Meningeal;Meningeal Nerve;Meninges;Migraine;Modeling;mouse model;Mus;Nerve;Nervous System Disorder;neural;Neurogenic Inflammation;Neuroimmune;Neurons;Neuropeptides;Nociceptors;Pain;pain behavior;pain model;Pathology;Pathway interactions;Peptides;Peripheral;Phase;Phenotype;pituitary adenylate cyclase activating polypeptide;Play;pre-clinical;receptor;Receptor Cell;Research;response;Role;socioeconomics;Stimulus;Testing;Thinness;Tissues;Transgenic Organisms;Visualization;Wild Type Mouse

PROJECT_TITLE: The role of neuro-immune interactions in PACAP induced migraine

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pain Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Relevance Dry eye disease, ocular pain and ocular discomfort present significant challenges to our quality of life. There has been recent interest in therapeutics directly targeting the activity of ocular cold sensory neurons, due to their key involvement in eye physiology, dry eye disease and ocular discomfort. Our proposal aims to dissect the function and activation mechanisms of the cold and menthol receptor TRPM8, a critical thermosensitive component of ocular cold sensory neurons, which will set the stage for the development of novel drugs to combat dry eye disease and ocular pain.

PI_NAMEs: HONG, JIYONG ;LEE, SEOK-YONG  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;Afferent Neurons;Age;Agonist;analog;Animal Model;antagonist;associated symptom;Binding;Binding Proteins;Binding Sites;Biochemistry;Biology;Birds;Blinking;Blurred vision;Calcium;Chemicals;Clinic;clinically relevant;cofactor;combat;Complex;Cryoelectron Microscopy;desensitization;design;Development;Disease;drug development;Dry Eye Syndromes;Dryness;Dysesthesias;Economic Burden;Elderly;Electrophysiology (science);Esthesia;Etiology;Exhibits;Eye;Eye diseases;Film;Force of Gravity;Future;GTP-Binding Proteins;Health;Homeostasis;Human;Hydration status;icilin;Image;In Vitro;Incidence;Inflammation;inhibitor;interest;Ion Channel;Irritants;irritation;Lead;Ligands;Liquid substance;member;Membrane;Menthol;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;Neurons;novel;novel therapeutics;ocular pain;Ocular Physiology;ocular surface;ocular surface disease;Ophthalmologic Surgical Procedures;Ophthalmology;Optometry;Pain;pain relief;Pathologic;Patients;Permeability;Pharmaceutical Chemistry;Phosphatidylinositol 4,5-Diphosphate;Play;Population;Public Health;Quality of life;receptor;Regulation;Role;Route;scaffold;sensor;Sensory Receptors;Shapes;Signaling Protein;Site;Societies;structural biology;Structure;Study models;surgical pain;Symptoms;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Trigeminal System;virtual screening;Visit;Visual;Women's prevalence;Work

PROJECT_TITLE: TRPM8 in eye health and disease

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Nutrition

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative Salmonella enterica serotypes are invasive enteric pathogens spread through fecal contamination of food and water sources and induce the disruption of intestinal barriers during infection and chronic inflammation. Vitamin D and the vitamin D receptor (VDR) are known to play a protective role in the pathogenesis of bacterial infection and digestive diseases. Our proposed studies are designed to investigate intestinal tight junctions regulated by the VDR and to develop novel therapeutic targets by enhancing function of intestinal VDR for alleviating bacterial infection.

PI_NAMEs: SUN, JUN  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Area;Atlases;Attenuated;Bacteria;Bacterial Infections;Bacterial Proteins;Biological Assay;Biology;Biomedical Engineering;Cells;Chronic;Colitis;Communicable Diseases;Compensation;conditional knockout;Data;design;Digestive System Disorders;Disease;Down-Regulation;Engineered Probiotics;Ensure;Enteral;enteric pathogen;Epithelium;Food Contamination;Funding;gain of function;Genes;Geography;Goals;gut inflammation;Homeostasis;Human;Image;Impairment;In Vitro;in vivo;Infection;Inflammation;innovation;insight;intestinal barrier;intestinal epithelium;Intestines;Invaded;Knowledge;Laboratories;Lactic acid;lactic acid bacteria;Lead;Literature;loss of function;Methods;Microbe;microbial;Microbiology;microbiome;Microscopy;Modeling;Molecular;Mucins;Mucositis;Mucous Membrane;multiplexed imaging;Mus;new therapeutic target;novel;Organoids;Outcome;overexpression;pathogen;Pathogenesis;Pathogenicity;Penetration;Permeability;Play;Predisposition;prevent;Probiotics;promoter;protein expression;Proteins;Proteomics;Public Health;Publications;Qualifying;receptor;receptor expression;receptor function;Receptor Inhibition;Regulation;repaired;Research;Research Personnel;Resistance;response;Role;Salmonella;Salmonella enterica;Salmonella infections;Serotyping;Severities;Solid;Source;Structure;Technology;Therapeutic;Tight Junctions;Tissues;tool;Tracer;Transgenic Mice;Transgenic Model;Vitamin D;Vitamin D Response Element;Vitamin D3 Receptor;Water

PROJECT_TITLE: How Vitamin D Receptor Influences Intestinal Barriers

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Transcatheter aortic valve replacement (TAVR) is an elegant lifesaving procedure for severely sick patients with heart valve diseases. TAVR is very safe, but in some TAVR patients their artificial heart valves degrade and fail, for reasons that are not known. This project will determine how blood cells become activated in TAVR patients in order to help develop better therapies for heart disease.

PI_NAMEs: ASLAN, JOSEPH E;DASI, LAKSHMI PRASAD;HINDS, MONICA T (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Age;Anatomy;Anticoagulants;Antiplatelet Drugs;Aorta;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Attenuated;Biochemical;Biochemistry;Biocompatible Materials;biomaterial compatibility;Blood;Blood Cells;Blood flow;Blood Platelets;Blood specimen;Charge;clinical development;clinical practice;Coagulation Process;comorbidity;cytokine;Data;defined contribution;Deterioration;Development;effective therapy;Engineering;experience;experimental study;Failure;Fibrin;Flow Cytometry;Generations;Glycoproteins;Goals;Health;Heart Diseases;Heart Valve Diseases;Heart Valve Prosthesis;Heart Valves;Hematology;hemodynamics;Hemostatic function;hospital readmission;Human;Hypertension;imaging modality;In Vitro;in vivo;Individual;individual variation;Inflammatory;innovation;Knowledge;Life;Measures;Mediating;Mediator;Methods;minimally invasive;Modeling;Molecular;Monitor;mortality;nonhuman primate;Operative Surgical Procedures;Outcome;oxidized lipid;Papio;Patient risk;Patients;Physicians;Physiological;Physiology;Platelet Activation;platelet phenotype;Population;Positron-Emission Tomography;prevent;Procedures;Process;Proteomics;receptor;Resolution;response;Risk;risk stratification;Safety;Scientist;Shunt Device;Signal Transduction;Specific qualifier value;Stents;Surface;System;Systems Biology;targeted treatment;Testing;Therapeutic;Thrombin;thrombogenesis;Thrombophilia;Thrombosis;thrombotic;thrombotic complications;tool;Translating;Variant;Work

PROJECT_TITLE: Patient-specific blood cell reactivity and flow dynamic profiles in transcatheter aortic valve replacement

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Skin Cancer

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: This project aims to understand how communication pathways between epidermal keratinocytes and melanocytes that promote the UV tanning response are hijacked in the developing melanoma niche to drive oncogenesis. A central player in keratinocyte:melanocyte communication is the keratinocyte adhesion molecule desmoglein 1, which is downregulated in response to UV or signals from transforming melanocytes and melanoma cells. We will test the idea that desmoglein 1's loss stimulates keratinocytes to produce extrinsic factors that inturn cause melanocytic cells toadopt new fates that drive tumor progression.

PI_NAMEs: GREEN, KATHLEEN JANEE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;acquired drug resistance;Adopted;Animal Model;Automobile Driving;Bar Codes;biomarker development;BRAF gene;Bypass;Cadherins;CDKN2A gene;Cell Adhesion Molecules;cell behavior;Cell Line;cell motility;Cells;Chronic;Coculture Techniques;Collaborations;Communication;cytokine;Data;desmoglein 1;Development;Disease;Down-Regulation;driver mutation;Elements;Environment;Environmental Risk Factor;Epidermis;Epithelium;Evaluation;experimental study;Exposure to;Gene Expression Profile;Genetic;Genetic Transcription;Genome;Goals;high risk;Human;human model;Image;In Vitro;in vivo;Inflammatory;inflammatory milieu;Intercellular Junctions;irradiation;keratinocyte;Label;Lead;Lesion;Malignant - descriptor;Malignant Neoplasms;Mammals;MAP Kinase Gene;Mediating;Mediator;melanocyte;Melanoma;Melanoma Cell;melanomagenesis;mouse model;mutant;neoplastic cell;Neural Crest;Nevus;non-genetic;novel;Nuclear;Oncogenes;Oxidative Stress;paracrine;Paracrine Communication;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phase;Positioning Attribute;predictive marker;Production;Property;Proteins;Proteomics;radiation response;Recovery;Reporter;response;RNA;Role;senescence;sensor;Shapes;Signal Pathway;Signal Transduction;single molecule;single-cell RNA sequencing;Skin tanning;slug;spatiotemporal;stemness;Stratum Basale;Stress;Testing;therapeutic target;Tissues;Transcription Repressor;transcriptional reprogramming;transcriptome;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Ultraviolet Rays;UV Radiation Exposure;Work

PROJECT_TITLE: Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Burden of Illness;Caregiving Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE This project will quantify the effects of the COVID-19 pandemic on the cognitive status of the older U.S. population and how the pandemic and attendant public health and social measures affected mortality and well- being among persons living with dementia and the older population in general. The project will use data on a large nationally representative sample and develop an enhanced model of cognitive status to estimate changes in ADRD trends before and following the COVID-19 pandemic in the population and in subpopulations. Our results will provide insights on the distribution of the medium- and longer-term burden of the pandemic on the older population and will aid with resource and policy planning.

PI_NAMEs: HURD, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acceleration;Affect;Age;Aging;Alzheimer's disease model;Alzheimer's disease related dementia;Anger;Caregivers;Characteristics;Classification;Clinical assessments;Cognition;Cognitive;cognitive ability;cognitive function;cognitive testing;Communities;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 susceptibility;Data;Data Collection;data harmonization;Death Rate;Dementia;dementia risk;demographics;Disease;Ethnic Origin;experience;Future;General Population;Geographic Locations;Happiness;Health;Health and Retirement Study;health data;Health Expenditures;Home;human old age (65+);Impaired cognition;Incidence;Individual;Infection;infection rate;informal care;informant;innovation;insight;interest;Interview;Life;Living Arrangement;Long COVID;Long-Term Care;Longitudinal Surveys;Marital Status;Masks;Measures;Memory;Mental Depression;Mental Health;Modeling;mortality;Nature;negative affect;Neuropsychological Tests;Nursing Homes;older adult;Older Population;Outcome;outcome disparities;Outcome Study;pandemic disease;pandemic impact;Personal Satisfaction;Persons;physical conditioning;Policies;Population;pre-pandemic;Prevalence;Probability;Protocols documentation;Public Health;Race;Reporting;Research;Resources;Respondent;response;Sampling;Sampling Studies;SARS-CoV-2 infection;satisfaction;sex;social;Social isolation;social stress;Socioeconomic Status;Spouses;Statistical Models;Stress;trend;Unmarried person;Update;Vaccination;Variant;Work

PROJECT_TITLE: The Effects of COVID-19 on the Well-being, Cognition and Mortality of Persons Living With Dementia

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project narrative The heart-surrounding pericardium provides mechanical protection to the ever-beating heart and supports cardiac development, growth, and regeneration; yet, its development remains understudied. We use the zebrafish as our model to visualize, track, and analyze the earliest stages of pericardium formation and its molecular control. Insights into the mechanisms of pericardium development are critical to understand congenital heart anomalies and the in vitro generation of therapeutic cell types for cardiac regeneration.

PI_NAMEs: MOSIMANN, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Advanced Development;beta catenin;Cardiac;cardiac regeneration;cardiogenesis;Cell Lineage;cell type;Cells;chemokine;Chemotaxis;ChIP-seq;cofactor;congenital heart abnormality;Coronary Vessels;Data;Defect;Development;Diagnosis;Disease;Disparate;Embryo;embryo cell;Endowment;Enhancers;Epithelium;experimental study;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth;healing;Heart;heart function;Heart Injuries;Homeostasis;Image;improved;In Situ;In Vitro;in vivo;Individual;Infection;Inflammation;injured;Injury;innovation;insight;Knowledge;Label;Lateral;Lung;Maps;Mechanics;Mesoderm;Mesothelium;Methods;Modeling;Molecular;Morphogenesis;multiple omics;mutant;Myocardial;Myocardium;Natural regeneration;Operative Surgical Procedures;Organ;Pathology;Pathway interactions;Pericardial body location;Pericardial cavity;pericardial sac;Pharyngeal structure;Positioning Attribute;progenitor;programs;Proliferating;Property;regenerative approach;regenerative cell;Regulatory Element;Repression;Research Proposals;response;Role;Signal Transduction;stem;stem cell population;Stromal Cell-Derived Factor 1;structural heart disease;Structure;synergism;Testing;Therapeutic;Tissue Grafts;Tissues;tool;transcription factor;transcriptome;Transgenic Organisms;Ventricular Remodeling;Visual;Visualization;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Decoding the transcriptional mechanisms of pericardium formation

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Stroke and neurodegenerative disease affect hundreds of thousands of individuals each year, leading to profound losses of motor function and severe impairments in daily living. In order to restore or replace lost functions in afflicted individuals, it is necessary to understand — and leverage — the brain’s remarkable learning capacity. This project aims to understand the different kinds of cognitive strategies people employ when learning a novel sensorimotor skill, which could prove to be critical in guiding rehabilitation training protocols that help people transfer gains made in the clinic to the real world.

PI_NAMEs: TAYLOR, JORDAN A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Activities of Daily Living;Adopted;Affect;Algorithms;Basic Science;Brain;Calibration;Cerebellum;Clinic;Cognition;Cognitive;cognitive capacity;Computational algorithm;Consumption;cost;Disease;Engineering;Exhibits;experimental study;Goals;Health;Heart;impaired capacity;Impairment;improved;Individual;insight;Learning;Learning Skill;Life;Literature;Maps;Measures;Methods;Motor;motor control;motor rehabilitation;Nature;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neuropsychology;novel;operation;Outcome;Participant;Pathway interactions;Performance;Persons;Play;Preparation;Process;Protocols documentation;Psyche structure;psychologic;recruit;Rehabilitation therapy;relative cost;Research;Resources;Retrieval;Role;Rotation;Route;Self-Help Devices;sensorimotor system;Shapes;Short-Term Memory;simulation;skills;Spinocerebellar Ataxias;Stroke;System;Testing;Time;Training;Variant;visual motor;Work

PROJECT_TITLE: Approaching sensorimotor learning from another angle: Exploring and leveraging different cognitive strategies for improving motor performance

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Our work has pioneered efforts to establish coagulation factor XI (FXI) as a safe and effective target to prevent thrombosis without increasing bleeding. Beyond activating FIX, we have identified mechanisms by which activated FXI promotes platelet activation, inflammation, and endothelial cell dysfunction, suggesting that the molecular steps of FXI activation and activity are ideal targets for the treatment and prevention of cardiovascular disease. Our work will provide mechanistic insights and preclinical proof-of-concept data for translating FXI inhibitors for use in thromboinflammation associated with hyperlipidemia.

PI_NAMEs: MCCARTY, OWEN J (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acceleration;Antibodies;Anticoagulation;atherogenesis;Atherosclerosis;Basic Science;Binding;Biochemical Reaction;Biomedical Research;Blood;Blood Cells;Blood Coagulation Factor;Blood Platelets;Blood Vessels;Bradykinin;C-reactive protein;cadherin 5;Cardiovascular Diseases;cardiovascular disorder prevention;Catheters;Cell Physiology;Clinical Trials;Coagulation Process;Complement Activation;Complex;Coupled;Data;Development;Dialysis patients;Dialysis procedure;Diet;diet-induced obesity;Disease;Dose;End stage renal failure;Endothelial Cells;endothelial dysfunction;Endothelial Plasminogen Activator Inhibitors;Endothelium;epidemiologic data;Factor XI;Factor XIa;first-in-human;Functional disorder;Funding;Generations;Goals;Grant;healthy volunteer;Hemodialysis;Hemorrhage;High-Molecular-Weight Kininogen;Hyperlipidemia;improved;in silico;In Vitro;in vivo;Indwelling Catheter;Inflammation;Inflammatory;inflammatory marker;inhibitor;insight;Kallikrein-Kinin System;KDR gene;Kininogens;Left ventricular structure;Legal patent;Link;Lipids;Mediating;member;Modeling;Molecular;molecular imaging;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;nonhuman primate;novel;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral Vascular Diseases;pharmacologic;Phase;phase 2 study;Phase II Clinical Trials;Plasminogen Activator Inhibitor 1;Platelet Activation;platelet preservation;pre-clinical;prevent;Prevention;Primates;Process;programs;prospective;Proteins;Recovery;Regulation;Reperfusion Therapy;Research;research to practice;Role;Signal Transduction;Site;Stroke;Systems Biology;Testing;TFPI;Therapeutic;Thrombin;thromboinflammation;Thrombosis;thrombotic;Thrombus;tool;Translating;Translational Research;Translations;Validation;Vascular Endothelium;vascular inflammation;Venous;Work

PROJECT_TITLE: Characterization of Coagulation Factor-platelet Interactions: Role of FXI

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Mental Health;Mental Illness;Neurosciences;Pain Research;Rehabilitation

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE The primary aims of this randomized, single-blinded, 2x2 sham-controlled trial are to 1) evaluate synergistic impact of 8-weeks of transcutaneous auricular vagus nerve stimulation (taVNS) + cognitive-behavioral therapy (CBT) on post-meal gut-brain communication; 2) determine the sequential relationship between treatment- associated changes in GI-related anxiety and both clinical functional dyspepsia (FD) improvements and meal- induced physiological outcomes; 3) investigate whether post-treatment changes in gut-brain physiology mediate improvements in FD clinical outcomes. Using our fully non-invasive framework including gastric and brain MRI and taVNS, we aim to evaluate the potential synergy of taVNS and CBT in FD, by assessing the gut-brain physiological response to prandial challenge, linking physiological with symptom improvements.

PI_NAMEs: SCLOCCO, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdomen;Adult;Affective;Afferent Pathways;Aftercare;Anxiety;Area;arm;attentional control;Brain;brain circuitry;brain magnetic resonance imaging;Brain Stem;Caring;Cell Nucleus;Chronic;chronic pain;Cine Magnetic Resonance Imaging;Clinical;clinical predictors;Clinical Trials;Cognition;Cognitive;Cognitive Therapy;comparison control;Data;design;Disease;disorders of gut-brain interaction;Dyspepsia;early satiety;effective therapy;Emotional;Emotions;Epigastric;Etiology;executive function;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gastric Emptying;gastrointestinal;Gastrointestinal Diseases;Goals;gut-brain axis;Health education;High Prevalence;imaging approach;improved;indexing;Individual;Ingestion;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Modality;Modeling;Motility;multi-component intervention;multimodality;negative affect;neural circuit;Neural Pathways;neuromechanism;neurophysiology;Nonpharmacologic Therapy;Nucleus solitarius;Outcome;Pain;Patients;Peristalsis;pharmacologic;Physiological;Physiology;post intervention;Randomized;Recommendation;Recurrence;response;Role;side effect;Signal Transduction;Single-Blind Study;Stimulus;Stomach;Sum;symptomatic improvement;symptomatology;Symptoms;synergism;targeted treatment;Testing;therapy outcome;treatment arm;Upper digestive tract structure;vagus nerve stimulation;Vagus nerve structure;Visceral

PROJECT_TITLE: Synergistic gut-brain axis modulation via vagal stimulation and cognitive behavioral therapy in functional dyspepsia

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

PHR: NARRATIVE The SPECTRUM study will characterize hormone use across a spectrum of gender identities. Characteristics of the steroid metabolome in gender minorities will individualize breast cancer screening depending on hormone use and gonad inventory. These results will directly inform breast screening guidelines to improve the health of transgender people who are too often invisible in national data collection.

PI_NAMEs: HOUGHTON, LAUREN C (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: Accounting;Age;aged;Ancillary Study;Androgens;assigned female at birth;assigned male at birth;Birth;Body mass index;Breast Cancer Detection;Breast Cancer Risk Factor;cancer care;Cancer Control;cancer risk;Characteristics;cis-female;cis-male;cisgender;Classification;cohort;Cohort Studies;Communities;Data;Data Collection;Deimplementation;Delphi Study;Detection;Dose;Equipment and supply inventories;Estrogens;Etiology;evidence based guidelines;Excretory function;Exogenous Hormone Therapy;experience;Family Cancer History;Female Breast Carcinoma;Gender;gender affirmation;gender affirming care;gender affirming hormone therapy;gender affirming hormones;Gender Identity;gender minority;gender minority group;Glucocorticoids;Gonadal structure;Guidelines;Health;health inequalities;High Prevalence;Hormonal;Hormone use;improved;Incidence;Individual;interest;Investments;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of male breast;Malignant Neoplasms;marginalized population;Menstrual cycle;metabolome;Methods;Molecular;neoplasm registry;Netherlands;nonbinary;Ovary;Participant;Personal Satisfaction;Persons;Phenotype;Population;prevent;Progestins;protective factors;Psyche structure;psychologic;Questionnaires;Radiation;recruit;Registries;Resources;response;Risk;Risk Factors;Role;screening;Screening for cancer;screening guidelines;sex assigned;Sexual and Gender Minorities;sexual minority;sexual minority group;Societies;Specimen;Standardization;steroid hormone;Steroids;Testing;Testis;Training;transgender;transgender men;transgender women;Translating;urinary;Urine;Vulnerable Populations;Woman

PROJECT_TITLE: SPECTRUM (Studying PRIDE to Enhance Cancer screening guidelines for TRansgender Users of gender-affirMing hormones)

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Pregnancy

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Public Health Relevance. Pregnancy confers unique susceptibility to infection by Listeria monocytogenes and other pathogens that primarily reside inside cells, as a means to evade protection by antibodies. We recently showed deacetylation of glycosylated antibodies expands their protective scope to intracellular infection, and this application will further investigate how pregnancy-modified antibody protect against perinatal infection.

PI_NAMEs: WAY, SING SING  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acetylation;Adult;Alloantigen;Antibodies;Antibody-mediated protection;antimicrobial;B-Lymphocytes;Binding;Birth;CD22 gene;CD8-Positive T-Lymphocytes;Cell membrane;cell type;Cells;Deacetylation;deacylation;Enzymes;esterase;fetal;Fetal Reduction;Fetal Tissues;Glycoproteins;glycosylation;Homing;Human;Humoral Immunities;IgG Receptors;Immune;Immunity;immunogenicity;Immunoglobulin G;Immunologics;improved;in vivo;Incubated;Individual;Infection;insight;Interleukin-10;Knowledge;Ligands;Link;Listeria monocytogenes;Listeriosis;Maternally-Acquired Immunity;Mediating;Microbe;Molecular;Mothers;Mus;Neonatal;neonatal immunity;neonate;pathogen;Pathogenesis;pathogenic bacteria;Perinatal;Perinatal Infection;Physiological;Placenta;Plasma Cells;Polysaccharides;postnatal development;Predisposition;Pregnancy;Pregnancy Outcome;pregnant;prenatal;prenatal exposure;Production;Property;Protein Glycosylation;public health relevance;reconstitution;residence;Rodent;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Specificity;Splenocyte;Systemic infection;Work

PROJECT_TITLE: Pregnancy induced deacetylation of sialylated glycoproteins

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Mental Health;Patient Safety;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Many people, especially older adults, take multiple medications and are therefore at high risk for dangerous drug interactions—a major clinical and public health issue. Medications that act in the brain are very commonly used yet may cause serious side effects such as blood clotting or bleeding, especially in the setting of drug interactions. This study will generate real-world evidence about which drugs adversely interact with three major classes of medications that act in the brain (i.e., antipsychotics, benzodiazepines, and antidepressants) to cause venous thromboembolism or serious bleeding.

PI_NAMEs: LEONARD, CHARLES EDWARD (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Achievement;Acute;Address;Affect;Aged, 80 and over;American;antagonist;anti-depressive agents;Antipsychotic Agents;Benzodiazepines;Bleeding time procedure;Blood coagulation;Blood Platelets;Brain;Cardiovascular Diseases;Case Study;Cessation of life;Chronic;Clinical;clinical decision support;clinically actionable;Cohort Studies;Computer software;computerized;Dangerousness;Data;design;Diabetes Mellitus;disabled;dissemination strategy;Dopamine;Dose;Drug Interactions;Drug Kinetics;Drug Prescriptions;Drug usage;Ensure;Epidemiologic Methods;ethnic minority;fall injury;falls;Fatigue;Focus Groups;forest;Gastric Acid Secretion Inhibition;Health;health disparity populations;Health Priorities;Healthcare;Hemorrhage;Heterogeneity;high risk;Hospitalization;human old age (65+);Iatrogenesis;improved;Individual;Injury;innovation;International;Knowledge;Machine Learning;Measures;Mental disorders;multidisciplinary;multiple chronic conditions;multiple drug use;novel;nursing skill;older adult;Outcome;Outcome Study;Patient risk;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phase;Platelet aggregation;Polypharmacy;Population;premature;Prevalence;prevent;Psychotropic Drugs;Public Health;racial minority;Research;response;reuptake;Risk;rural dwellers;Safety;screening;Series;Serotonin;side effect;Signal Transduction;Specific qualifier value;Subgroup;support tools;systematic review;Testing;Thromboembolism;treatment effect;venous thromboembolism;World Health

PROJECT_TITLE: Drug interactions involving psychoactive drugs

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Adeno-associated virus (AAV) vectors have become the leading biologics in the clinical treatment of several monogenetic diseases but pre-existing immunities and toxicities at high doses limit their wide-spread utilization. In this project we will characterize the interactions of the AAV capsids with human antibodies, proteins of the innate immune system, receptors, and other intracellular proteins. This project will guide our capsid engineering efforts to overcome the challenges of the host immune responses and efficient gene transfer thereby improving clinical efficacy.

PI_NAMEs: MCKENNA, ROBERT  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Adaptive Immune System;Address;adeno-associated viral vector;Affect;Amino Acid Sequence;Amino Acids;Antibodies;Attention;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Biological Products;Birds;Capsid;Cell Nucleus;Cell Surface Receptors;Cells;cellular transduction;clinical efficacy;Clinical Treatment;clinical trial participant;Clinical Trials;clinically relevant;cohort;Complement;Complement 3b;Complement Activation;complement system;Complex;Cross Reactions;cross reactivity;Cryoelectron Microscopy;Data;Data Set;Defensins;delivery vehicle;Dependovirus;design;Disease;Distant;Dose;Dose Limiting;Dot Immunoblotting;Eligibility Determination;Engineering;Exclusion;Exposure to;Funding;Gene Delivery;gene therapy;Gene Transfer;Genome;goose parvovirus;Heat-Shock Proteins 70;Histones;Human;human monoclonal antibodies;Immune response;Immune system;Immunity;improved;Inflammatory;Innate Immune System;Kinetics;Maps;member;Mendelian disorder;Monoclonal Antibodies;murine monoclonal antibody;Mus;neutralizing antibody;novel;nuclear transfer;nucleolin;Patients;Polysaccharides;Population;preference;prevent;Prevention;Primates;Property;Proteins;rational design;receptor;receptor binding;Recombinant adeno-associated virus (rAAV);Residual state;Resolution;Sea Lions;Series;Serotyping;Site;Structure;success;Surface;System;Therapeutic;Toxic effect;trafficking;transduction efficiency;transgene expression;Transgenes;Treatment Efficacy;Tropism;Variant;vector

PROJECT_TITLE: AAV capsids and their cellular interactions

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Photoreceptor cells utilize a prototypical G-protein signaling cascade, called phototransduction, to convey the presence of light. Genetic mutations and environmental factors that affect the performance of phototransduction cause many different forms of blinding diseases through mechanisms that are poorly understood. Investigation of these mechanisms will help in the design of treatment options for visual disorders arising from dysfunction of the phototransduction cascade.

PI_NAMEs: CHEN, JEANNIE  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acute;Affect;Arrestins;Attenuated;Blindness;Calcium;calcium indicator;Calibration;Calpain;Cell Compartmentation;Cell Death;Cell membrane;Cells;Chimeric Proteins;Crowding;Cyclic GMP;Darkness;Disease;DNA Sequence Alteration;Environment;Environmental Risk Factor;Equilibrium;experimental study;Exposure to;Failure;Feedback;Female;Fluorescence;fluorescence imaging;Functional disorder;Functional Imaging;Genes;GTP-Binding Proteins;Health;hereditary blindness;Homeostasis;Human;Hydrolysis;Image;imaging detector;Integral Membrane Protein;Investigation;Knowledge;Lead;Light;live cell imaging;Maintenance;male;Measurement;Microscope;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;multi-photon;Mus;mutant;Mutant Strains Mice;Mutation;Neurons;novel therapeutics;Pathologic;Performance;phosphodiesterase 6;Photons;photoreceptor degeneration;Photoreceptors;Phototransduction;prevent;Process;ratiometric;recruit;red fluorescent protein;Regulation;Reporter;Retina;Retinal Cone;Retinal Degeneration;Retinal Pigments;retinal rods;Retinitis Pigmentosa;Rhodopsin;Role;Route;sensor;Signaling Protein;Slice;Stress;Synapses;Testing;therapy design;Time;tool;Vertebrate Photoreceptors;Vision Disorders;Visualization

PROJECT_TITLE: Phototransduction in health and disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


FUNDING_MECHANISM: OTHERS

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: The goal of this proposal is to develop an improved therapeutic strategy for immune checkpoint inhibitor-resistant melanoma. Although immunotherapy with checkpoint inhibitors has revolutionized treatment for advanced melanoma, only 40-60% of patients experience lasting medical benefits from this therapy. Notably, Veterans have an increased risk of developing and dying of melanoma compared to the general population. Thus, identifying new mechanisms to target melanoma is critical to improve survival in Veterans with this disease. Inflammation has been demonstrated to influence melanoma growth and response to checkpoint inhibitors. However, no therapy developed to date is designed to target it. NLRP3 is a central driver of melanoma autoinflammation, making it an attractive target candidate. This project will evaluate how NLRP3 regulates melanoma response to checkpoint inhibitors and will explore its potential as therapeutical target.

PI_NAMEs: MARCHETTI, CARLO  (contact)

PROJECT_TERMS: 3-Dimensional;autoinflammation;Biological Process;Complement 4b;design;Disease;experience;General Population;Goals;Growth;Immune checkpoint inhibitor;Immunotherapy;improved;Inflammation;Medical;Melanoma;Patients;Resistance;response;Risk;therapeutic target;therapy development;translational potential;Veterans

PROJECT_TITLE: To Elucidate the Biological Function and Translational Potential of NLRP3 in Immunotherapy-resistant Melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCE-A (01)]


NIH_SPENDING_CATS: Diabetes;Genetics

PHR: Project Narrative Failure of pancreatic β cells underlies the progression of all forms of diabetes. We investigate critical functions of the transcription factor and diabetes gene PDX1 through intra-molecular regulation of protein stability, and inter-molecular interactions regulating subcellular/subnuclear localization, in part through phase separation. The results from these studies will deepen our fundamental understanding of Pdx1 and help to design better strategies to generate and expand β cells in vitro and in vivo, with the potential to identify new nodes for intervention to prevent or delay the onset of diabetes.

PI_NAMEs: GANNON, MAUREEN A;SOLEIMANPOUR, SCOTT ;STOFFERS, DORIS A (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Architecture;Attenuated;Beta Cell;Binding;biophysical properties;blood glucose regulation;C-terminal;Cell Count;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell Differentiation process;cell growth;Cell Therapy;Cells;Complex;Confocal Microscopy;Data;design;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;dosage;Embryo;Enhancers;Exhibits;Exposure to;Failure;flexibility;Gene Expression;Gene Expression Regulation;Gene Modified;Generations;Genes;Genetic Transcription;Glucose;Glucose Intolerance;glycemic control;Hi-C;Home;homeodomain;Human;In Vitro;in vivo;insulin promoter factor 1;insulin secretion;intermolecular interaction;Intervention;islet;Knowledge;Link;live cell imaging;Maintenance;Maps;Mediating;member;Mitogens;Mitosis;Molecular Conformation;molecular imaging;mouse model;Mus;mutant;novel;Nuclear;Optics;overexpression;Pancreas;Pathogenesis;Patients;Phase;Phenotype;Play;Post-Translational Protein Processing;postnatal;prevent;Proliferating;promoter;protein protein interaction;Protein Region;Proteins;Regulation;response;Role;single molecule;Structure;Structure of beta Cell of islet;superresolution microscopy;Testing;Therapeutic;transcription factor;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Structure dictates dynamic topology and function of pancreatic transcriptional regulators

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Suicide

ORG_CITY: HERSHEY

ORG_DEPT: PSYCHIATRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Personality disorders in youth are associated with profound personal and societal burden, but very little is known about the processes underlying personality impairment in youth, hindering efforts to identify effective interventions for this vulnerable population. For this prospective longitudinal study, a clinically diverse psychiatric outpatient sample of 160 early adolescent youth and 80 healthy comparison youth without a history of psychopathology (ages 10-13; 50% female) will be recruited to test neurophysiological alterations in social acceptance processing and self-referential processing as predictors of personality impairment over two years. Findings will guide the development of preventative efforts to mitigate the personal and societal burden associated with personality impairment within this sensitive developmental period.

PI_NAMEs: BABINSKI, DARA E (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescent;Adopted;Adult;Age;Anxiety;Attention;Attention deficit hyperactivity disorder;behavior observation;Caring;Characteristics;Childhood;Clinic;Clinical;clinical care;clinically significant;Complex;conduct problem;cost;critical developmental period;Cues;Development;Diagnosis;Dimensions;Disease;disease classification;early adolescence;Ecological momentary assessment;effective intervention;Electroencephalography;Emergency department visit;Event-Related Potentials;Female;flexibility;Functional disorder;Functional impairment;Growth;Impairment;improved;Individual Differences;Inequity;inpatient psychiatric treatment;insight;Intensive Care;International;Intervention;intervention refinement;Level of Evidence;life span;longitudinal, prospective study;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;National Institute of Mental Health;neural;neuromechanism;neurophysiology;Outcome;Outpatients;Parents;Pathology;Patient Self-Report;peer;Personality;Personality Development;Personality Disorders;Process;Psychiatry;Psychopathology;Recording of previous events;recruit;Research;Research Domain Criteria;Resistance;response;Rewards;Risk;Sampling;Self Perception;social;social deficits;Social Processes;social stigma;sociodemographics;Stigmatization;substance use;suicidal;suicidal risk;Suicide;Testing;trait;Transact;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Testing Developmental Mechanisms of Personality Impairment in Youth

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Osteoarthritis;Pain Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Genicular artery embolization (GAE) is a new minimally invasive treatment option for the millions of patients suffering from osteoarthritis of the knee. While initial results for GAE are promising, there is potential for a large placebo effect with this therapy. The proposed pilot study will compare GAE to a sham procedure to help provide an initial understanding of any placebo effect and help us design a larger future study to prove GAE is an effective treatment for knee osteoarthritis.

PI_NAMEs: AHMED, OSMAN  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;advanced disease;Adverse event;Affect;afferent nerve;Age;American;Angiography;Arteries;Blood flow;Body Weight decreased;Catheterization;Chronic;Clinical;Consensus;contrast enhanced;Control Groups;cost;Degenerative polyarthritis;design;Development;Disease;Double-Blind Method;effective therapy;efficacy validation;Enrollment;experience;Future;Growth;Hypertrophy;imaging biomarker;improved;indexing;Inflammation;Injections;Institution;Intervention;Interventional radiology;joint function;Joints;Knee;Knee joint;Knee Osteoarthritis;knee pain;knee replacement arthroplasty;Left;Magnetic Resonance Imaging;Medical;Microspheres;minimally invasive;Multicenter Studies;multidisciplinary;neovascular;Nerve Fibers;novel;Operative Surgical Procedures;osteoarthritis pain;Outcome;Pain;pain outcome;pain reduction;pain relief;pain score;particle;Pathologic;Patient Outcomes Assessments;Patients;Perfusion;Persons;Pharmacological Treatment;phase III trial;Phenotype;Physical therapy;Pilot Projects;Placebo Control;Placebo Effect;placebo group;Placebos;Population;power analysis;Procedures;Public Health;Publishing;Radiology Specialty;Randomized;randomized placebo controlled study;Refractory;Replacement Arthroplasty;Reporting;Research Priority;Resolution;response;Risk;Roentgen Rays;sham-controlled study;Societies;Symptoms;Synovial joint;Synovial Membrane;Synovitis;Techniques;Therapeutic Embolization;Tissues;tool;Western Ontario and McMaster Universities Arthritis Index

PROJECT_TITLE: Genicular Artery Embolization for Reducing Pain in Medically Refractory Mild to Moderate Osteoarthritis: A Double-Blind, Randomized Sham-Controlled Pilot Study

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: The proposed research is relevant to public health because its overarching goal is to develop an effective therapy for one of the most debilitating manifestations of Parkinson’s disease: freezing of gait. The study proposes to develop novel imaging biomarkers to optimize response to deep brain stimulation (DBS) for patients with freezing of gait. The project is relevant to NIH’s mission because it aims to further the understanding of factors that underlie effective response to DBS in patients with freezing of gait in order to improve efficacy.

PI_NAMEs: REVUELTA, GONZALO JAVIER (contact)

PROJECT_TERMS: Affect;Anisotropy;Area;Behavior assessment;blood oxygen level dependent;Brain;Brain region;Cell Nucleus;Clinical;clinical predictors;Data;Deep Brain Stimulation;Diffusion Magnetic Resonance Imaging;disability;Dopa;effective therapy;Freezing;Functional Imaging;Functional Magnetic Resonance Imaging;functional MRI scan;Gait;Globus Pallidus;Goals;Image;imaging biomarker;improved;in vivo;Individual;innovation;Lead;Location;Longitudinal Studies;Mission;Modeling;Motor Cortex;multimodal neuroimaging;neural;novel;novel strategies;Operative Surgical Procedures;Parkinson Disease;Patient Recruitments;patient response;Patients;Pattern;Postoperative Period;prevent;Public Health;Quality of life;Research;responders and non-responders;response;Severities;Site;STN stimulation;structural imaging;Structure;Structure of subthalamic nucleus;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;treatment response;United States National Institutes of Health

PROJECT_TITLE: Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Meiosis is a cell division program that is essential for the formation of both eggs and sperm and therefore critically important for human reproductive health. Errors during meiosis are a leading cause of miscarriages, infertility and birth defects such as Down Syndrome in humans. This application will investigate the regulation of the synaptonemal complex, a structure required for promoting accurate meiotic chromosome segregation in most organisms from yeast to humans, thereby laying the foundation for the development of effective preventive strategies.

PI_NAMEs: COLAIACOVO, MONICA P (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Aneuploidy;Architecture;ASH1L gene;Biochemical;Biochemical Process;Biological Assay;Biology;Caenorhabditis elegans;Cell division;Cell Nucleus;Chromatin;Chromosome Pairing;Chromosome Segregation;Chromosomes;Congenital Abnormality;Conserved Sequence;Coupled;CRISPR/Cas technology;Cytology;Data;Deacetylation;Development;Diploidy;DNA biosynthesis;DNA Double Strand Break;Double Strand Break Repair;Down's Syndrome;egg;Engineering;Ensure;Event;Exhibits;Failure;fly;Foundations;Frequencies;Funding;gene conservation;Gene Expression;Genes;Genetic;Genetic Crossing Over;Genetic Nondisjunction;Genetic Recombination;Genome;Germ Cells;Germ Lines;Goals;Haploidy;Health;histone methylation;Homologous Gene;Human;In Vitro;in vivo;Infertility;insight;Laboratories;Lead;Licensing;Light;Link;Mass Spectrum Analysis;Mediating;Meiosis;Meiotic Prophase I;Microscopy;Mitosis;Molecular;Molecular Structure;Molecular Target;Monitor;mutant;N-terminal;Nematoda;novel;Oogenesis;Organism;Pathway interactions;Phosphorylation;Phosphotransferases;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;preservation;Prevention strategy;Process;programs;Prophase;Protein Acetylation;Proteins;Regulation;Regulatory Pathway;repaired;Reproductive Health;Role;Series;Site;sperm cell;Spermatogenesis;Spontaneous abortion;stillbirth;Structure;superresolution imaging;Synaptonemal Complex;System;transcriptome sequencing;Work;Yeasts

PROJECT_TITLE: Synaptonemal Complex Assembly and Function in Meiosis

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]