ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: COLUMBIA

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: SC

PHR: Following return from the Gulf War (GW), veterans have experienced of a constellation of symptoms, designated Gulf War Illness (GWI), that includes structural and functional deficits in the central nervous system (CNS), along with cardiovascular complications. GWI is a progressive disorder in that the number of veterans diagnosed with GWI continues to rise in the post-deployment period. Mechanistically, studies suggest that neuroinflammation is a key component in the progression of GWI. Based on these observations, the goal of this project is to directly test our hypothesis that immune challenges and stressful stimuli lead to exacerbated neuroimmune, neurochemical, cardiovascular and behavioral deficits after exposure to cholinesterase inhibition, which would be highly consistent with the progress nature of GWI pathophysiology. Most importantly, these studies will identify loci for therapeutic intervention that can be quickly tested in our model and implemented for the treatment of GWI in our veterans.

PI_NAMEs: REAGAN, LAWRENCE P (contact)

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Acute;Address;Affect;Animal Model;Arrhythmia;associated symptom;Behavior;behavior measurement;behavior test;Behavioral;behavioral response;Brain;Bromides;Cardiovascular Physiology;Cardiovascular system;Central Nervous System;cholinergic;Cholinesterases;Chronic;cytokine;Diagnosis;Disease;Etiology;Exhibits;experience;Exposure to;Functional disorder;Funding;Goals;Gulf War;Gulf War veteran;heart rate variability;Hippocampus;Immune;Immune response;in vivo;Inflammatory;Lead;Lipopolysaccharides;Measures;Microdialysis;Microglia;Modeling;Nature;neurochemistry;Neurocognitive Deficit;Neuroimmune;neuroinflammation;Neurosecretory Systems;novel;Performance;Persian Gulf Syndrome;physiologic stressor;Plasma;Prefrontal Cortex;pressure;pyridostigmine;Rattus;Recording of previous events;response;restraint stress;Rodent Model;social stress;social stressor;Stimulus;Stress;stress reactivity;Stressful Event;Symptoms;Telemetry;Testing;Therapeutic Intervention;Veterans

PROJECT_TITLE: Immune basis for hippocampal cholinergic deficits in pyridostigmine-treated rats


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Narrative We will evaluate the proof of concept that highly sophisticated genomic procedures can be used to guide the efficacy of targeted treatment. We will use single-cell genomics to identify the brain cells most susceptible to brain trauma. We have identified the thyroid hormone transport gene Ttr as one the most affected by TBI, and we propose to target Ttr using T4 treatment, expecting to normalize plasticity and altered gene circuits.

PI_NAMEs: GOMEZ-PINILLA, FERNANDO  (contact);YANG, XIA

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Affect;Astrocytes;Behavior;Behavioral;Bioenergetics;Biological;Biological Assay;Blood;Brain;brain cell;Brain Concussion;Brain Injuries;Brain region;Cell Communication;cell type;Cells;Cellular Metabolic Process;Circulation;Cognitive;cognitive ability;Data;Defect;Development;Diagnostic;dosage;droplet sequencing;Energy Supply;frontal lobe;functional decline;Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genomics;Hippocampus;In Situ Hybridization;Individual;Inflammation;Injury;Instruction;Intervention;Metabolic;metabolic depression;Metabolic dysfunction;Metabolism;mild traumatic brain injury;Molecular;Monitor;myelination;Nervous System Disorder;neural circuit;neural repair;Neuronal Plasticity;neuronal survival;Neurons;new therapeutic target;Normal Cell;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Performance;Phase;Phenotype;Play;precision medicine;Precision Medicine Initiative;Predisposition;Procedures;programs;response;restoration;RNA;Role;Secondary to;single cell analysis;single cell genomics;single cell sequencing;Symptoms;Systems Biology;targeted treatment;TBI treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Thyroid Hormones;Thyroxine;Time;Traditional Medicine;transcriptomics;Traumatic Brain Injury;Treatment Efficacy;treatment strategy

PROJECT_TITLE: Precision Medicine Approach:  Using genomic information to guide TBI treatment


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms. Among Veterans with mTBI, the majority also experience stress-based psychopathology (e.g., depression, post-traumatic stress disorder, and/or generalized anxiety disorder) and chronic pain. To cope with distress, pain, and other difficulties, Veterans often turn to maladaptive avoidant coping strategies which offer short term relief but exacerbate/maintain mental health problems and have detrimental long-term effects on social, occupational, and community reintegration. Unfortunately, Veterans face important barriers to seeking mental health treatment, including stigma and logistical issues. This proposal aims to examine 1) the impact of a Veteran-centered, non-stigmatizing, 1-day “life skills group workshop” on overall distress and reintegration; and 2) the mechanisms by which this treatment might work as well as possible influences on treatment efficacy.

PI_NAMEs: DINDO, LILIAN NAZAR (contact);JORGE, RICARDO E.

PROJECT_TERMS: active method;Address;Afghanistan;Aftercare;Anxiety;Anxiety Disorders;Area;barrier to care;Behavior;Behavioral;Belief;career;Caring;Characteristics;chronic pain;Communities;community reintegration;comorbidity;comparative efficacy;coping;Coping Skills;demographics;Diagnosis;Diagnostic;Distress;Education;Educational workshop;efficacy evaluation;emotional distress;Ensure;evidence base;Evidence based intervention;Exhibits;experience;Exposure to;Face;Family;Feedback;follow-up;Freedom;Functional disorder;Generalized Anxiety Disorder;Goals;Grant;Health;Health Status;improved;Intervention;Iraq;Life;Long-Term Effects;Mediating;Mediator;Medical;Mental Depression;Mental Health;Mental Health Services;mild traumatic brain injury;Military Personnel;Minority;Mission;Modeling;Multiple Trauma;Occupational;operation;Outcome;Pain;Pain interference;Participant;Patients;Pattern;Pharmaceutical Preparations;Phase;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;primary outcome;Psyche structure;psychologic;Psychopathology;psychosocial;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Resources;secondary outcome;service member;service utilization;Severities;skills;social;social stigma;Societies;Stigmatization;Stress;Symptoms;Time;Traumatic Brain Injury;treatment adherence;treatment as usual;treatment comparison;Treatment Effectiveness;Treatment Efficacy;treatment response;Veterans;Visit;Work;wound

PROJECT_TITLE: One-day Life Skills Workshop for Veterans with TBI, pain, and Psychopathology: Evaluating efficacy and mechanism of change

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Kidney Disease;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Defects in temperature and osmolarity sensation lead to various human diseases, including neurological, renal, and metabolic disorders. The proposed work will facilitate our understanding of thermosensation and osmosensation in humans and their related diseases.

PI_NAMEs: XU, SHAWN  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Ablation;Animal Behavior;Animals;Behavior;Behavioral;Biology;Brain imaging;Caenorhabditis elegans;cold temperature;Cues;Defect;Disease;Electrophysiology (science);Environment;Esthesia;Genetic;Genetic Models;Goals;Human;human disease;insight;Kidney Diseases;Lasers;Lead;Life;Mammals;Metabolic Diseases;Modality;model organism;Modeling;Molecular;Molecular Genetics;Nervous System Disorder;neural;neuromechanism;novel;Organism;Osmolar Concentration;Osmosis;receptor;Research;Sensory;Sensory Receptors;sensory system;Temperature;Temperature Sense;Work

PROJECT_TITLE: Neural and genetic mechanisms underlying behavior in C. elegans

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Bipolar Disorder (BD) and Major Depressive Disorder (MDD) commonly emerge during adolescence, representing a period of increased risk for psychopathology, and risk is further heightened for youth with a family history of these disorders. The proposed study will use data from the Adolescent Brain Cognitive Development (ABCD) Study to identify distinct neurobiological profiles of high familial risk for BD and MDD among healthy youth, and to investigate whether these vulnerability markers predict the subsequent onset and longitudinal course of psychopathology across adolescence. Findings from this study will elucidate neural mechanisms underlying risk for psychopathology among vulnerable youth, which has the potential to inform approaches for early and accurate detection of psychiatric illness, thereby significantly improving mental health outcomes.

PI_NAMEs: HOLT-GOSSELIN, BAILEY  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Amygdaloid structure;Anterior;Biological;Biological Markers;Bipolar Disorder;Brain;brain based;Brain region;career;Child;Clinical;clinical diagnosis;cognitive development;Corpus striatum structure;Data;design;Detection;Development;Dimensions;disability;Disease;disorder risk;Dorsal;Early Diagnosis;Early Intervention;early onset;Emotions;Exhibits;Family history of;Funding;Human;improved;ineffective therapies;insight;interest;Intervention;intervention program;Investigation;Knowledge;Lateral;longitudinal course;longitudinal dataset;Major Depressive Disorder;Measurement;Medial;Mental disorders;Mental Health;Mentorship;Modeling;Mood Disorders;multidisciplinary;National Research Service Awards;neural;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Outcome;Pattern;predictive marker;Predisposition;Prefrontal Cortex;psychiatric symptom;Psychopathology;Recording of previous events;recruit;Research;resilience;Rest;Rewards;Risk;Risk Marker;Sample Size;Severities;Statistical Models;suicidal risk;Symptoms;Time;Training;United States National Institutes of Health;Ventral Striatum;Youth

PROJECT_TITLE: Neurobiological markers of risk and resilience for psychopathology in youth at familial risk for mood disorders


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative LIF is frequently overexpressed in colorectal cancer (CRC), but its role and mechanism in CRC is poorly defined. This proposed study aims to determine the role and mechanism of LIF in CRC, and assess targeting LIF-driven metabolic reprogramming in colorectal tumor-initiating stem-like cells as an effective strategy for CRC therapy. We expect that results from this study will deepen our understanding of the role and mechanism of LIF in CRC, and provide potential new therapeutic targets and strategies for CRC with LIF overexpression.

PI_NAMEs: HU, WENWEI  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: anti-cancer;ApcMin/+ mice;Azoxymethane;base;cancer cell;Cancer Etiology;cancer initiation;cancer type;CD36 gene;CDX2 gene;Cell Count;Cell Physiology;Cells;Cessation of life;chemical carcinogen;Clinical;Colon;colon cancer patients;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Complex;cytokine;Data;Development;enhancing factor;Epithelium;Fatty Acids;Feedback;gene repression;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;In Vitro;in vivo;Internal Ribosome Entry Site;Intestines;Knock-in Mouse;Knock-out;Knockout Mice;leukemia inhibitory factor receptor;LGR5 gene;LIF gene;LIFR gene;lipid metabolism;Lipids;LoxP-flanked allele;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Molecular;mouse model;Mus;neutralizing antibody;new therapeutic target;Oncogenic;overexpression;oxidation;Pathologic Processes;Pathway interactions;Physiological Processes;Play;Prognosis;Reporting;Reproduction;Role;Sampling;Signal Transduction;small molecule inhibitor;stem cell niche;stem cells;stem-like cell;stemness;targeted treatment;Testing;Therapeutic;therapy resistant;Time;Tissues;TP53 gene;transcription factor;tumor;tumor initiation;Tumor Promotion;Tumor Suppression;Tumor Suppressor Genes;tumorigenesis;uptake;Work

PROJECT_TITLE: The role of leukemia inhibitory factor in colorectal cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Most brain cancers are incurable, in part because they grow back after treatment and resist additional therapy. Our data show that these cancers produce a protein called Tissue Factor, and that Tissue Factor greatly increases the malignant behavior of brain cancer. Tissue Factor is needed for normal blood clotting, but cancers also produce it for themselves, allowing them to regrow and resist treatment. We will study why Tissue Factor does this, and determine whether it is possible to block its activity in order to make brain cancers less aggressive, without interfering with normal clotting.

PI_NAMEs: HORBINSKI, CRAIG MICHAEL (contact);LATHIA, JUSTIN D.

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adhesions;Adult;Aftercare;AKT1 gene;Back;Behavior;Binding;Blood coagulation;Brain;c-myc Genes;cancer stem cell;Caring;Cell Adhesion Molecules;cell behavior;Cell Maintenance;Cell-Cell Adhesion;Cells;Chemotherapy and/or radiation;chromatin immunoprecipitation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Complex;conventional therapy;Cytotoxic Chemotherapy;Data;Diagnosis;Disease;Epidermal Growth Factor Receptor;Excision;FOS gene;Foundations;G-Protein-Coupled Receptors;Gene Silencing;Genes;Genetic Transcription;genotoxicity;Glioblastoma;Growth;Hemorrhage;Hemostatic function;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Integrin Inhibition;Integrins;JUN gene;junctional adhesion molecule;knock-down;Knock-out;Laboratories;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;MAP Kinase Gene;Mediating;Membrane;Molecular;neoplastic cell;new therapeutic target;Normal tissue morphology;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Outcome;overexpression;PAR-2 Receptor;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;pharmacologic;PIK3CG gene;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;programs;promoter;Protein Secretion;Proteins;Publishing;Receptor Activation;Receptor Protein-Tyrosine Kinases;Recurrent tumor;Resistance;response;Role;self-renewal;Serine Proteinase Inhibitors;Serpins;Signal Transduction;stem cell population;stem cell self renewal;stem cell survival;stemness;success;Testing;Therapeutic;therapeutic target;therapeutically effective;Thromboplastin;Tissue Model;Toxic effect;transcription factor;Translations;tumor;tumor eradication;United States;Work

PROJECT_TITLE: Interaction between Tissue Factor, Junctional Adhesion Molecule-A, and Integrin B1 to drive self-renewal in glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-C(02)M]


NIH_SPENDING_CATS: Genetics

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative The proposed research on group II intron and related reverse transcriptase will provide novel information about the mechanism and evolution of reverse transcriptases, retrotransposons, and retroviruses, all of which are relevant to human diseases. The proposed research also includes the development of new methods for next- generation RNA sequencing, the use of these methods to study human diseases, and the application of these methods in new approaches for RNA-based diagnostics and liquid biopsy.

PI_NAMEs: LAMBOWITZ, ALAN M. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Bacteria;Biochemical;Biological Process;Biotechnology;biotypes;Cell Physiology;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Diagnostic;Engineering;Evolution;extracellular vesicles;follow-up;Foundations;High-Throughput RNA Sequencing;Human;human disease;improved;Introns;Length;liquid biopsy;Malignant Neoplasms;Methods;next generation;novel;novel strategies;Organism;Plasma;Property;Regulation;Research;Retroelements;Retrotransposon;Retroviridae;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;RNA-Directed RNA Polymerase;Roentgen Rays;Structure;System;thermophilic organism;thermostability;transcriptome sequencing;Transfer RNA;Untranslated RNA;Work

PROJECT_TITLE: Group II Intron and Related Reverse Transcriptases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Nutrition;Obesity;Prevention;Primary Health Care

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: 8. Project Narrative Overweight and obesity affect a large majority of Americans, increasing their risk for multiple chronic illnesses. It is recommended that physicians provide weight management counseling (WMC) to patients having overweight or obesity, but physicians have limited WMC training. Residency is an ideal time to teach physicians WMC skills, but residency programs lack an evidence-based curriculum to support this need. Our study addresses this gap by testing MRWeight, an innovative technology-assisted spaced education program designed specifically for teaching WMC to medical residents.

PI_NAMEs: OCKENE, JUDITH K;SADASIVAM, RAJANI  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adoption;Adult;Advocate;Affect;American;American Heart Association;analog;Assessment tool;Behavior;Caring;Characteristics;Chronic Disease;Clinical;clinical implementation;clinical practice;cohort;Communication;Comparison arm;comparison intervention;Complex;Counseling;crowdsourcing;design;Diet;Dissemination and Implementation;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;Effectiveness of Interventions;Electronic Mail;Epidemic;Evaluation;evidence base;Feedback;follow-up;Future;gateway course;Guidelines;Health;Heart Diseases;innovative technologies;Intention;Internal Medicine;Intervention;intervention effect;Knowledge;Learning;Matched Group;Mediating;Mediator;Medical;Medical Education;Medical Examiners;medical schools;Methods;multimodality;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity associated disease;Obesity Epidemic;obesity prevention;obesity treatment;Outcome;Overweight;Patient Care;patient oriented;Patient Self-Report;Patients;Physical activity;Physicians;Pilot Projects;Play;Post Graduate Year;Primary Care;primary care setting;primary care visit;Process;Process Measure;Program Appropriateness;programs;Psychological reinforcement;Public Health;Publishing;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Residencies;response;Risk;Self-reflection;sex;Site;skill acquisition;skills;social cognitive theory;Stroke;Technology;Technology Assessment;Testing;Text;Time;Training;Training Programs;United States;United States National Institutes of Health;uptake;Visit;Weight;Weight maintenance regimen

PROJECT_TITLE: MRWeight: Medical Residents Learning Weight Management Counseling Skills -- A Multi-Modal, Technology-Assisted, Spaced Education Program

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Relevance In recent years, much has been discovered about how the motor cortex enables reaching movements, but the bulk of this research has not yet included neurophysiological studies of how we interact with objects such as tools. Results of this project could provide valuable insight into the fundamental principles of this control and advance our understanding of the way we act on our surroundings. The decoding algorithms developed in this work will be used for neural prostheses that restore the ability of paralyzed subjects to manipulate objects in their surroundings.

PI_NAMEs: SCHWARTZ, ANDREW B. (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;arm;Behavior;cognitive process;Collaborations;Compensation;Complex;control theory;Data;design;Dimensions;electric impedance;Electromyography;Environment;Feedback;Hand;Human;insight;interest;Isometric Exercise;Joints;kinematics;Knowledge;Limb structure;mathematical model;Measurement;Measures;Mechanics;Modeling;Monitor;Monkeys;Motion;Motor;Motor Activity;motor control;Motor Cortex;Movement;multidisciplinary;Muscle;neural;neural correlate;neural model;neural prosthesis;Neurons;neurophysiology;neuroregulation;nonhuman primate;novel;operation;Paralysed;Pattern;Population;Primates;prosthesis wearer;Reaction;Reflex action;Rehabilitation therapy;Research;Research Personnel;Resistance;response;Robot;robot control;Sampling;Series;Signal Transduction;skeletal;Specific qualifier value;Statistical Models;stretch reflex;Structure;System;Testing;theories;Time;tool;Torque;Variant;virtual;Virtual Tool;Viscosity;Work

PROJECT_TITLE: Motor cortical signaling of impedance during manipulation

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The central aim of these studies is to identify a novel, circuit-based target for the treatment of anxiety disorders characterized by maladaptive fear memory, such as post-traumatic stress. Our proposal puts forth a glial-based mechanism for the systems-level consolidation of a fear memory, providing a novel target for future therapeutics.

PI_NAMEs: CHAN, JONAH R;KHEIRBEK, MAZEN A (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Ablation;Address;Adult;Amygdaloid structure;Area;Axon;Behavioral;Brain;brain dysfunction;cell type;Cells;Chronic;Code;Communication;Data;Electrophysiology (science);Elements;entorhinal cortex;experience;fear memory;Fright;Future;gene induction;Gene Modified;Generations;Genetic;Goals;Hippocampus;Histologic;Immediate-Early Genes;Impairment;improved;in vivo;in vivo calcium imaging;in vivo imaging;Individual;innovation;insight;Interneurons;Investigation;Learning;Life;Link;long term memory;Measures;Medial;Memory;memory encoding;memory recall;memory retrieval;Microscopy;Mus;Myelin;myelination;Nature;neural;neural circuit;Neural Inhibition;Neurons;neurotransmission;novel;oligodendrocyte progenitor;Oligodendroglia;Output;Parvalbumins;Positioning Attribute;post-traumatic stress;precursor cell;Prefrontal Cortex;Preparation;Process;Production;Proliferating;Regulation;Reporting;Resolution;Retrieval;Role;Specificity;System;Techniques;temporal measurement;Testing;Therapeutic;Translating;treatment of anxiety disorders;two-photon;Viral;Work

PROJECT_TITLE: Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrieval

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: CHARLESTOWN

ORG_NAME: AMPLIFIDX INC

PHR: NARRATIVE AmplifiDx will develop an assay for point-of-care diagnosis of sexually transmitted infections (STIs) - Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) - and detection of antibiotic resistant or susceptible genes in NG that will provide treatment recommendation and a urine collection device. The assay will run on the DX-1000 device, currently under advanced development for COVID-19 detection, and will utilize the simple, single step ‘swab to answer’ workflow that is already developed and expand the use to urine samples which are commonly used in STI clinics, allowing physicians to receive diagnoses and prescribe treatments in the span of a single visit.

PI_NAMEs: DONG, SHOULIAN  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Acceleration;Advanced Development;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Area;assay development;Biological Assay;Ceftriaxone;Chemistry;Chlamydia trachomatis;Clinic;Clinical;Collection;Communicable Diseases;Complex;Country;COVID-19;COVID-19 detection;COVID-19 diagnostic;Cytolysis;design;Detection;detection assay;Development;Devices;Diagnosis;Diagnostic tests;diagnostic tool;DNA;FDA Emergency Use Authorization;follow-up;Force of Gravity;Funding;Genitourinary system;Health;Health care facility;in-vitro diagnostics;Incidence;Infertility;Infrastructure;instrument;internal control;isothermal amplification;Liquid substance;Magnetism;manufacture;manufacturing cost;Marketing;miniaturize;Molecular;multiplex assay;Mutation;Neisseria gonorrhoeae;Optics;Output;Patients;Physicians;point of care;Point of Care Technology;point of care testing;point-of-care diagnosis;point-of-care diagnostics;pressure;Privacy;Process;prototype;Questionnaires;RADx;rapid diagnosis;Reagent;Recommendation;Research;Resistance;resistance gene;Resource-limited setting;Risk;Running;Sampling;Sexually Transmitted Diseases;social stigma;Surveys;Susceptibility Gene;Swab;System;Testing;tool;Urine;usability;Validation;validation studies;Visit

PROJECT_TITLE: STI NG Plus, a Swab to Answer Molecular Panel Test for Point of Care Diagnosis and Treatment Recommendation


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NORTH CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: Narrative Understanding the mechanisms governing how the brain flexibly adjusts it networks to process rapidly changing stimuli is of enormous human health significance. The short term goal of this proposal is to investigate the mechanisms by which neurons are rapidly reallocated to and from active networks depending on the stimulus of the moment. Our long term goal is to use the insights gained from this study to stimulate new approaches and perspectives for understanding and treating cognitive decline associated with aging and disease.

PI_NAMEs: FROST, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Affect;Aging;Automobile Driving;Brain;Cognitive;cognitive function;Data;Disease;Effectiveness;Electrophysiology (science);Elements;Fire - disasters;flexibility;Goals;Health;Human;Image;Impaired cognition;Individual;insight;Maps;marine;Motor;neural network;Neurons;novel strategies;operation;Periodicity;phenomenological models;Play;Population;prevent;Process;programs;Property;rapid growth;Recurrence;Reporting;Role;Sensory;sensory input;Stimulus;Swimming;System;Time;Vertebrates;voltage sensitive dye;Work

PROJECT_TITLE: Mechanisms of stimulus-induced network focusing


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hypertension

PHR: Project Narrative Inappropriate production of aldosterone, the most common adrenal disease, causes hypertension, cardiovascular damage, and enchanced potential for metabolic syndrome. Recently, using a small cohort of adrenals from patients with primary aldosteronism due to bilateral idiopathic hyperaldosteronism (IHA), we identified a set of somatic mutations that causes autonomous aldosterone production. These findings form the foundation for this competitive renewal application that will test three hypotheses: i) due to the common nature of this disease, normal adrenals can be used to define the cellular origins and pathogenesis of primary aldosteronism resulting from somatic gene mutations (Aim 1), ii) IHA is caused by an expansion and accumulation of aldosterone-producing cell clusters that have somatic gene mutations in calcium channels (Aim 2), iii) the activating calcium channel mutations found in IHA adrenals provide a therapeutic target to inhibit the autonomous aldosterone production in IHA (Aim 3).

PI_NAMEs: RAINEY, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: adenoma;Adrenal Glands;adrenal hypertension;Adult;Age;Aldosterone;American;Amlodipine;antagonist;Automobile Driving;Bilateral;blood pressure regulation;Calcium;Calcium Channel;Calcium Channel Blockers;carbohydrate metabolism;Cardiovascular Diseases;Cardiovascular system;Cell model;Cells;Cessation of life;Clinical;cohort;Cohort Studies;Collection;CYP11B2 gene;Development;Dihydropyridines;Disease;Disease Progression;Distal;DNA;DNA Sequence Alteration;driver mutation;drug repurposing;Electrolyte Balance;Equilibrium;exome sequencing;Formalin;Foundations;Funding;Gene Mutation;Gene Targeting;Genetic;Grant;High Prevalence;Human;Hyperaldosteronism;Hyperplasia;Hypertension;hypertensive;Immunohistochemistry;improved;In Vitro;in vivo;Kidney;Kidney Diseases;Life;Medical;Metabolic syndrome;Mineralocorticoid Receptor;Molecular;Mutation;Mutation Analysis;Nature;next generation sequencing;novel therapeutics;Operative Surgical Procedures;Paraffin Embedding;Pathogenesis;Patients;Peripheral;Pharmaceutical Preparations;Physiological;Physiology;Play;Population;Potassium;Prevalence;Production;Receptor Activation;renal damage;Renin;Renin-Angiotensin System;Research;research and development;Role;sex;side effect;Sodium;Somatic Mutation;Source;Steroids;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;voltage gated channel;Zona Glomerulosa

PROJECT_TITLE: Adrenal Origins of Aldosterone Excess


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE This study will provide mechanistic insight into how deprotection of stalled forks potentiates oncogene-induced senescence (OIS) and how pre-malignant cells under replication stress overcome OIS and establish oncogenic transformation. My study aims to lay the foundation for targeting TIM gain-of-function as a way to sensitize cancer cells to oncogene-induced DNA replication stress. Understanding the nature of TIM in OIS can pave new ways to inhibit TIM, resensitize cancer cells, and ultimately prevent tumorigenesis.

PI_NAMEs: PARK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;anti-cancer;Bypass;cancer cell;cancer type;Cancerous;cell injury;Cells;Complex;Data;Defect;Development;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA replication fork;DNA Replication Induction;Down-Regulation;Event;Excision;Failure;Fibroblasts;Foundations;gain of function;Genomic Instability;Goals;Human;Impairment;insight;knock-down;Knowledge;KRASG12D;Lesion;Link;Maintenance;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Missense Mutation;Mitogens;Modeling;Modification;Molecular;mutant;Nature;neoplastic;novel;Oncogene Activation;Oncogenes;Oncogenic;Organoids;overexpression;Pathway interactions;Poly Adenosine Diphosphate Ribose;Post-Translational Protein Processing;Premalignant Cell;prevent;Proliferating;Prostate;prostate cancer model;protective pathway;ras Oncogene;replication stress;response;Role;scaffold;Seminal;senescence;Signal Induction;Signal Transduction;small hairpin RNA;Stimulus;Structure;targeted cancer therapy;Techniques;Testing;tumor initiation;tumorigenesis;Up-Regulation

PROJECT_TITLE: Pathways of oncogene-induced senescence at DNA replication forks


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: TEANECK

ORG_NAME: FAIRLEIGH DICKINSON UNIVERSITY

PHR: PROJECT NARRATIVE Women involved in criminal justice systems (WICJ), the majority of whom are reproductive-aged, have high rates of illicit substance use disorders (SUDs) and unmet contraceptive needs, (i.e., fecund, sexually active, and report not wanting more children or wanting to delay the next child, but are not using any method of contraception), leading to high rates of unintended pregnancies, and morbidity and mortality among women and their offspring. Culturally sensitive interventions that address barriers to substance use and sexual and reproductive health (SRH) treatment are lacking among WICJ, and evidence-based HIV-prevention interventions for WICJ who use drugs can provide a key platform for simultaneously addressing these needs. This proposed study will enable the candidate to identify and address key determinants of drug and contraceptive use among reproductive-aged WICJ to adapt a digital intervention (videoconference group-based treatment and digital interactive activities) with high capacity for real-world implementation and dissemination, to help reduce health disparities in SUD and SRH treatment among WICJ.

PI_NAMEs: SLAVIN, MELISSA N. (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Abortion Rates;acceptability and feasibility;addiction;Address;Adult women;advocacy organizations;Age;aged;AIDS prevention;Area;Barrier Contraception;barrier to care;Child;Communities;community advisory board;condoms;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Criminal Justice;culturally appropriate intervention;Data;digital;digital intervention;Dissemination and Implementation;Dropout;drug testing;Drug usage;effective intervention;Effectiveness of Interventions;efficacy trial;Ethnic Origin;Evaluation Research;evidence base;Feedback;fitness;follow-up;Future;Gender;Goals;Hair;health disparity;health inequalities;Health Services Accessibility;HIV;illicit drug use;implementation science;Imprisonment;improved;Individual;infection risk;Intervention;Interview;intimate partner violence;Low Birth Weight Infant;Mentored Research Scientist Development Award;Methods;Modeling;Multimedia;National Institute of Drug Abuse;obstetrical complication;offspring;Oral Contraceptives;Outcome Study;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;pilot test;Population;Postpartum Depression;power analysis;Pregnancy;premature;Prenatal care;prevent;preventive intervention;primary outcome;Provider;Race;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reduce health disparities;Reporting;reproductive;Research;Research Ethics;Research Methodology;Research Personnel;responsible research conduct;Risk Factors;satisfaction;Schools;Science;secondary outcome;Self Efficacy;sexual and reproductive health;sexually active;Sexually Transmitted Diseases;skills;Social support;Social Work;Socioeconomic Status;Stress;stress reduction;Structure;substance use;Substance Use Disorder;Supervision;System;Testing;Training;unintended pregnancy;Universities;videoconference;War;Woman;women's morbidity;Women's mortality;women's treatment

PROJECT_TITLE: Adaptation of a Digital Group-Based Intervention to Reduce Drug Use and Increase Contraceptive Use among Reproductive-Aged Women Involved in Criminal Justice Systems

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Acute megakaryoblastic leukemia is a pediatric cancer that lacks targeted treatment options and has variable survival. The proposed research is relevant to public health because the elucidation of the molecular mechanisms driving development of acute megakaryoblastic leukemia will provide avenues of investigation for potential novel therapeutics and will enhance understanding of epitranscriptomic dysregulation in cancer. Thus, the long-term goals of the proposed research will contribute to the part of the NIH’s mission that pertains to advancement of scientific knowledge to understand illness and enhance health.

PI_NAMEs: MAYDAY, MADELINE YOUNG (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 4 year old;acute megakaryoblastic leukemia cell;Acute Megakaryocytic Leukemias;Adenosine;Automobile Driving;beta catenin;Binding;Cancer Biology;candidate selection;cell growth;Cell Line;Cells;Child;Chimeric Proteins;chromatin remodeling;Complex;Computer Analysis;crosslink;crosslinking and immunoprecipitation sequencing;Cytotoxic Chemotherapy;Data;Deposition;Development;Diagnosis;Disease;DNA Sequence Alteration;epitranscriptome;epitranscriptomics;experimental study;FUS-1 Protein;Gene Expression;Genes;Goals;Health;Hematopoiesis;Immunoprecipitation;improved;improved outcome;In Vitro;in vivo;infancy;insight;interest;Investigation;knock-down;Knowledge;leukemia;Leukemic Cell;leukemogenesis;Maintenance;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Megakaryocytes;Messenger RNA;Mission;Modeling;Modification;Molecular;Mus;Mutation;Neonatal;Neonatal Leukemia;neonate;novel therapeutics;Oncogenic;Pathway interactions;Patient-Focused Outcomes;Pattern;Phenotype;Physiological;Play;posttranscriptional;Property;Protein Binding Domain;Proteins;Public Health;Reader;recruit;Recurrence;Reporting;Research;RNA;RNA Binding;RNA-Binding Proteins;Role;Scientific Advances and Accomplishments;side effect;Survival Rate;targeted treatment;Techniques;Testing;therapeutic target;Transcript;Transcription Coactivator;transcriptome;transcriptome sequencing;transcriptomics;tumorigenesis;United States National Institutes of Health;Western Blotting;WNT Signaling Pathway;Work

PROJECT_TITLE: Elucidation of the molecular mechanisms of the RBM15-MKL1 fusion protein in acute megakaryoblastic leukemia


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Taxanes, a class of tubulin inhibitors, are a mainstay chemotherapy for patients diagnosed with stage IV breast cancer, but are limited by onset of drug resistance and dose-limiting neurological toxicities. We have discovered a new generation of tubulin inhibitors that bind to a different site of tubulin that not only bypass taxane resistance, but also are efficiently delivered to the brain. In this proposal, we will perform focused structural optimization that will be efficiently guided by X-ray crystallography and computer-aided drug design to ultimately produce a first- in-class, metabolically stable (having long duration of action in humans) tubulin inhibitor that can reverse taxane resistance and can be targeted to the brain and to bone, without inducing neurological toxicities, with the ultimate goal of eradicating established metastases to prolong survival (achieving “no evidence of disease”, NED, status).

PI_NAMEs: LI, WEI  (contact);SEAGROVES, TIFFANY NICOLE

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: ABCG2 gene;advanced prostate cancer;Affinity;analog;anti-cancer;Area;Binding;Binding Sites;Biological Availability;bisphosphonate;bone;Brain;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Bypass;Cancer Patient;Cell Line;Cells;Chemistry;chemotherapy;Clinic;Clinical;clinical candidate;clinical efficacy;Colchicine;Complex;Computer Assisted;COVID-19;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;docetaxel;Dose;Dose Limiting;Drug Design;Drug Kinetics;Drug resistance;effective therapy;Effectiveness;efficacy study;ERBB2 gene;FDA approved;Generations;Goals;Hematopoietic;Human;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;invention;Investigational Drugs;Lead;lead optimization;Lung;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Liver;Modeling;Modification;mortality;Multi-Drug Resistance;Mus;Neoplasm Metastasis;Neurologic;Neuropathy;neurotoxicity;Neutropenia;next generation;No Evidence of Disease;Normal Cell;novel;novel therapeutics;Oral;overexpression;Paclitaxel;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Penetration;Peripheral Nervous System Diseases;Pharmaceutical Preparations;phase II trial;phase III trial;Pre-Clinical Model;prevent;Primary Neoplasm;Progression-Free Survivals;Property;Proteins;Quality of life;Refractory;Resistance;resistance mechanism;Resolution;Roentgen Rays;scaffold;Site;Solid Neoplasm;standard of care;Structure;Survival Rate;targeted treatment;taxane;Therapeutic;Therapeutic Index;Toxic effect;Treatment Protocols;triple-negative invasive breast carcinoma;Tubulin;tumor;tumor growth;Tumor-Derived;X-Ray Crystallography

PROJECT_TITLE: Targeting brain and bone metastases in metastatic breast cancer for improved patient survival

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Diabetes and related metabolic disorders are rapidly increasing and have major impacts on both the quality of life and the lifespan of the US population, and are therefore responsible for a large portion of our health care cost burden. The goals of the Einstein-Mount Sinai Diabetes Research Center are to provide resources for molecular, cellular, tissue, organismal, pre-clinical, clinical and translational research to improve our understanding of development of diabetes and its prevention, treatment and eventual cure.

PI_NAMEs: PESSIN, JEFFREY E. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acceleration;Adenoviruses;Advocacy;Animal Model;Animals;Area;Award;Awareness;base;Basic Science;Behavioral Sciences;bench to bedside;bench-to-bedside translation;Biomedical Research;career;Clinical;Clinical and Translational Science Awards;clinical investigation;Clinical Research;Collaborations;college;Core Facility;Data;Development;Diabetes Mellitus;Educational workshop;Ensure;Environment;Epidemiology;Etiology;Evolution;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Feasibility Studies;Fees;Fostering;Funding;Goals;Grant;Growth;Health Care Costs;Human;improved;Infrastructure;innovation;Institution;International;Investigation;islet;Knowledge;Laboratories;Leadership;life span;medical schools;Medicine;meetings;Mentors;Metabolic Diseases;Metabolism;metabolomics;metropolitan;Molecular;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;New York;New York City;outreach;Patients;Physiology;Pilot Projects;Population;pre-clinical research;preclinical study;Prevention;Productivity;programs;Quality of life;recruit;Research;Research Personnel;Research Project Grants;Resources;Services;stable isotope;Strategic vision;Structure;symposium;Technology;Tissues;Training;Training and Education;Training Programs;Translating;Translational Research;Translations;type I and type II diabetes


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Accountability;Advisory Committees;Advocacy;Animals;Applications Grants;Area;Award;base;Biomedical Research;Collaborations;college;Core Facility;cost effectiveness;cost efficient;Creativeness;Development;Diabetes Mellitus;Educational workshop;Endocrine System Diseases;Ensure;Ethics;Evaluation;Evolution;Faculty;Feasibility Studies;Fertilization;Fostering;Funding;Generations;Grant;Health system;Human;Human Resources;improved;Individual;Infrastructure;innovation;Institution;inter-institutional;Leadership;Maintenance;medical schools;Medicine;member;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;metropolitan;Mission;New York;Obesity;Pilot Projects;Policies;Procedures;Productivity;programs;Public Health;Quality Control;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Science;senior faculty;Services;success;Supervision;symposium;System;Talents;Technology;tool;Translations;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Einstein-Mount Sinai Diabetes Research Center


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Wound Healing and Care

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE (RELEVENCE) Infectious keratitis is a global burden but the epidemiology on causative etiologies and antimicrobial resistance (AMR) patterns worldwide is lacking. This project takes advantage of international collaborations and recent advances in genomic technologies to identify pathogens and provide regional AMR profiles to these infections. The results of this study will decrease AMR proliferation and improve diagnostics and therapeutic approaches for infectious keratitis, thus reducing the burden of corneal blindness in both rich and poor countries.

PI_NAMEs: DOAN, THUY A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Age;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;Awareness;Bacterial Infections;Biological Testing;Blindness;Cataloging;Characteristics;Classification;Climate;Clinical;Collaborations;Communicable Diseases;Cornea;Corneal Opacity;Corneal Ulcer;Country;deep sequencing;Detection;Diagnostic;Diagnostic Procedure;Disease;disease diagnostic;Disease Outcome;Economics;Epidemiology;Etiology;Fingerprint;Frequencies;fungus;Fusarium;Gene Expression Profile;Genomics;Genotype;Geographic Locations;Geography;Goals;Health;Immune;Immune response;improved;Infection;International;Keratitis;Knowledge;Location;Metagenomics;Microsporidia;Minority;Morbidity - disease rate;Mycoses;novel;Nucleic Acid Amplification Tests;Organism;Outcome;Parasites;Parasitic infection;pathogen;Pathogenesis;Pattern;Perforation;Phenotype;predict clinical outcome;Predisposition;prevent;Proliferating;Public Health;Research;Resistance profile;Sampling;Seasons;Secondary to;Stains;standard of care;Surface;Technology;Testing;Therapeutic;transcriptome;Ulcer;United States;Virus Diseases;Vision;Visual

PROJECT_TITLE: Improving Corneal Ulcer Outcomes with Unbiased Pathogen and Antimicrobial Resistance Detection

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


PI_NAMEs: SCHWARTZ, GARY J (contact)

PROJECT_TERMS: Acute;Adipose tissue;Animals;base;Behavior;Biological Assay;blood glucose regulation;Brain;Carbohydrates;Closure by clamp;Core Facility;Darkness;Data Analyses;Denervation;design;detection of nutrient;Diabetes Mellitus;Diet;dietary;Drug or chemical Tissue Distribution;Eating;Electromyography;energy balance;Energy Metabolism;Exercise;fatty acid metabolism;fatty acid oxidation;Functional Magnetic Resonance Imaging;Gastric Bypass;gastrointestinal;Glucose;glucose metabolism;glucose monitor;Glycogen;Goals;Hepatic Tissue;Histologic;Homeostasis;Hyperglycemia;Image;in vivo;Indirect Calorimetry;Instruction;Insulin;insulin sensitivity;intrahepatic;Light;Lipids;Liver;Magnetic Resonance Spectroscopy;Measurement;Mediating;Metabolic;Metabolism;Methodology;microCT;microPET;Mission;Molecular;Motor Activity;Mus;Muscle;Mutation;neurosurgery;Nuclear Magnetic Resonance;Obesity;Pancreas;Performance;pharmacologic;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Rattus;Research;Research Methodology;Research Personnel;Rodent;Rodent Model;Role;Scanning;Scientist;Services;Shivering;Signal Transduction;skeletal tissue;Students;Study models;Techniques;Temperature;Thermogenesis;Tissues;tool

PROJECT_TITLE: Einstein Mount Sinai Diabetes Research Center


PI_NAMEs: KURLAND, IRWIN JACK (contact)

PROJECT_TERMS: Adenoviruses;Adipocytes;Anabolism;analytical method;Animal Model;Animals;Biochemical;Biological;Biological Assay;Biological Sciences;Carbohydrates;Cells;Citric Acid Cycle;Clinical Investigator;Collection;Computer Analysis;Core Facility;cost effective;Coupled;dalton;Data Analyses;design;Diabetes Mellitus;Diagnosis;Dissection;Experimental Designs;experimental study;extracellular;Feces;Gas Chromatography;Genus Hippocampus;Glucose;glucose disposal;glucose production;Glycerol;Glycolysis;Goals;Hepatic;Homeostasis;Human;human model;Human Resources;implantation;improved;In Vitro;in vivo;Infrastructure;Infusion procedures;inorganic phosphate;instrument;ion mobility;islet;Islet Cell;Isotopes;lipid biosynthesis;lipidomics;Lipids;liquid chromatography mass spectrometry;Liquid substance;Lymph;Measurement;Metabolic;Metabolic Pathway;metabolic rate;Metabolism;metabolomics;Mission;Mitochondria;Molecular;Muscle;Osmosis;Oxygen Consumption;Pathway interactions;Peripheral;Phosphocreatine;Physiological;Physiology;Plasma;Preparation;Production;Protein Biosynthesis;Pump;Recycling;Research;Research Personnel;Resolution;Respiration;Rodent;Services;stable isotope;Students;synergism;Technology;Time;tissue culture;Tissue Sample;tissue/cell culture;Tissues;Tracer;Translational Research;Update;Urine;Water;Work


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Women's Health Research

PHR: RELEVANCE A significant proportion of women who receive chemotherapy for breast cancer will experience long- term problems with brain function, such as thinking, memory and attention that reduce quality of life and extend disease-related disability. The proposed study aims to validate a model for predicting who will develop long-term cognitive impairment and to examine the underlying causes of this impairment. This research is highly relevant to breast cancer, one of the most common public health problems, affecting 1 in 8 women.

PI_NAMEs: KESLER, SHELLI R (contact);PALESH, OXANA G

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adverse event;Affect;Algorithms;Attention;Brain;Brain Injuries;Breast Cancer therapy;cancer therapy;chemobrain;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical Management;clinical practice;Cognitive deficits;Cognitive Therapy;connectome;Data;Decision Making;Diffuse;Diffusion Magnetic Resonance Imaging;disabling disease;Enrollment;experience;falls;Female;Functional Magnetic Resonance Imaging;General Anesthesia;Goals;Home;Impaired cognition;Impairment;improved;Incidence;individual patient;Injury;insight;Life;Machine Learning;machine learning model;machine learning prediction algorithm;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Medical;Memory;Methods;Modeling;Motor;multimodal neuroimaging;neuroimaging;neuromechanism;Newly Diagnosed;novel;Occupational;Oncologist;Operative Surgical Procedures;Outcome;outcome prediction;Patients;Pattern;prediction algorithm;predictive modeling;Property;Public Health;Quality of life;Research;Risk;Role;Sampling;Schedule;Sensory;social;Structure;Syndrome;Testing;Thinking;Time;Treatment Protocols;Validation;Woman;Work

PROJECT_TITLE: Predicting Long-Term Chemotherapy-Related Cognitive Impairment

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This T32 training program will facilitate the development of a diverse and highly trained workforce that will ultimately assume leadership roles related to global mental and behavioral research. This program will train researchers to conduct culturally and contextually approach research to address the global burden of mental problems and improve well-being for vulnerable populations in low-resource settings globally.

PI_NAMEs: BASS, JUDITH KAREN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Mental Health;Training Programs

PROJECT_TITLE: Global Mental Health Training Program


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: GARCIA-OCANA, ADOLFO  (contact)

PROJECT_TERMS: Adenoviruses;Affect;allotransplant;Alpha Cell;base;Beta Cell;Bioenergetics;Biological Assay;Biology;cDNA delivery;Cell Differentiation process;cell growth;Cell Line;Cell Physiology;Cell Proliferation;cell regeneration;cell type;community center;Data Analyses;design;Diabetes Mellitus;Diabetic mouse;Education;euglycemia;experimental analysis;Failure;Floor;Fluorescence-Activated Cell Sorting;Functional disorder;Funding;Gene Delivery;Goals;Grant;Human;Human Resources;Immunocompromised Host;Immunodeficient Mouse;In Vitro;in vivo;Infrastructure;insight;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulinoma;interest;Investigation;Investigator-Initiated Research;islet;Islet Cell;Islets of Langerhans Transplantation;Lentivirus;medical schools;member;Methodology;Methods;Mission;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;New York City;Non-Insulin-Dependent Diabetes Mellitus;Persons;Physiological;Population;Postdoctoral Fellow;Preparation;Proliferating;Protocols documentation;Publications;PubMed;Rattus;Reagent;Research;Research Design;Research Personnel;Research Support;Rodent;Services;small hairpin RNA;student training;Technology;Tissues;tool;Translating;type I and type II diabetes;Viral Vector;Xenograft procedure


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Infectious Diseases

ORG_CITY: AUGUSTA

ORG_DEPT: DENTISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Periodontitis (PD) is one of the most common inflammatory diseases in the U.S, contributing to increased risk of other diseases with more serious mortality and morbidity profiles, but as yet there is no effective immunotherapy for PD. Understanding how gingival immune cells contribute to inflammatory bone loss and how to “reprogram” them to preserve bone, using dendritic cell-derived exogenously developed exosomes, is the goal of this proposal. Our first exosome prototype, enriched with TGF and IL-10, fulfills this novel premise in mice, but the precise mechanisms involved, and the direct relevance to endogenous exosomes from humans with PD need to be established, as outlined in these aims.

PI_NAMEs: ELSAYED, RANYA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adaptive immune response;Alveolar Bone Loss;Anti-Inflammatory Agents;Antigen Presentation;Antigens;Autoimmune Diseases;Autologous Dendritic Cells;Biodistribution;bone;bone preservation;C-Type Lectins;cancer biomarkers;cancer clinical trial;CD4 Positive T Lymphocytes;CD86 gene;Cell Maturation;Cells;Chronic;Communication;Custom;cytokine;Data;Degenerative Disorder;Dendritic Cells;Development;Diagnostic;Disease;Early identification;Endocytosis;exosome;Experimental Models;Future;Gingiva;Goals;Histopathology;Human;Immune;immune function;Immune response;Immunobiology;Immunotherapy;improved outcome;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Response;Injections;Interleukin-10;Lesion;MADH2 gene;Malignant Neoplasms;Mediating;Microbe;Molecular;Morbidity - disease rate;mortality;mouse model;Mouth Diseases;Multivesicular Body;Mus;nanoparticle;nanosized;novel;novel strategies;novel therapeutic intervention;Oral;oral infection;Organ;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Periodontitis;Periodontium;Peripheral;Phase I/II Clinical Trial;Phenotype;Plasma;premature;preservation;prevent;programs;Proteins;Proteomics;prototype;Publishing;receptor;receptor binding;Regulatory T-Lymphocyte;Reporting;response;Risk;Role;Safety;Saliva;Salivary;secondary lymphoid organ;Secondary to;Signal Transduction;Site;STAT3 gene;System;T-Lymphocyte;Testing;Therapeutic;Tissues;Transforming Growth Factor beta;uptake

PROJECT_TITLE: DC exosome therapy to resolve inflammatory bone loss and oral infection

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


PI_NAMEs: DILORENZO, TERESA P (contact)

PROJECT_TERMS: Address;antigen-specific T cells;Area;Awareness;base;Biological;Biological Assay;Biology;Biomedical Research;Biophotonics;Cells;Collection;Complex;Consultations;cost;cost effective;Custom;Cytometry;Data Analyses;design;Diabetes Mellitus;Economics;Education;extracellular;high dimensionality;Hybrids;Image;Image Analysis;Immune system;Immunohistochemistry;Immunologics;Immunology;immunoregulation;in vivo imaging;Infrastructure;inter-institutional;Investments;islet;Liquid substance;Methodology;Modality;multiplexed imaging;new technology;novel;Obesity;operation;Performance;Price;programs;Protocols documentation;Reagent;recruit;Research;Research Personnel;Resources;Scientist;Services;Specialist;Specimen;Structure;success;Technology;technology platform;technology validation;Testing;Time;Tissues;tool;type I and type II diabetes;Validation;Visualization;whole body imaging;whole slide imaging;Work


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  The overall goal of this proposal is to elucidate the cellular and molecular mechanisms governing the assembly of motor and sensory circuits required for coordinated movement. Our studies will investigate the role of cell fate determinants in establishing synaptic specificity in spinal circuits, and determine how developmental programs contribute to the emergence of specific motor behaviors. Defining the genetic pathways controlling neuronal diversification and connectivity provides basic insights relevant to the study of diseases and injuries that affect spinal motor circuit function.

PI_NAMEs: DASEN, JEREMY S (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Affect;Architecture;Behavior;Breathing;Cells;comparative;design;Development;Disease;Equilibrium;Family;gene function;Genetic;genetic manipulation;genome-wide;Goals;Homeobox Genes;HOX protein;Injury;insight;Mammals;Methods;Modernization;Molecular;Motor;motor behavior;motor control;Motor Neurons;Movement;Muscle;nerve supply;neural circuit;Neural tube;neuromechanism;Neurons;Organism;Pathway interactions;Peripheral;Play;presynaptic;programs;repaired;Research;Role;Sensory;Shapes;Specific qualifier value;Specificity;Spinal;Spinal Cord;Spinal Degenerative Disorder;Synapses;Therapeutic;transcription factor;Walking;Work

PROJECT_TITLE: Genetic Control of Circuit Assembly in the Vertebrate Spinal Cord


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition

PI_NAMEs: CRANDALL, JILL P (contact)

PROJECT_TERMS: Acceleration;Adipose tissue;Area;arterial tonometry;Award;base;Behavioral;Biological Markers;Biopsy;Blood Vessels;Body Composition;Clinical;Clinical and Translational Science Awards;clinical efficacy;clinical investigation;Clinical Investigator;Clinical Research;clinical training;Clinical Trials;Closure by clamp;Collaborations;college;Communities;Complement;Consultations;Continuous Glucose Monitor;design;Diabetes Mellitus;efficacy study;Emerging Technologies;Exposure to;Faculty;Fatty acid glycerol esters;Fees;first-in-human;Future;Grant;Growth;Health;Hour;Human;Human Resources;Human Subject Research;implementation research;in vivo;Infusion procedures;Institution;Laboratories;Letters;Measurement;medical schools;Medicine;member;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Muscle;new technology;Obesity;Outcomes Research;Patient Recruitments;patient safety;Performance;Peripheral;Physiology;Positioning Attribute;Procedures;programs;Protocols documentation;reactive hyperemia;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Subjects;Resources;Series;service delivery;Services;Techniques;Technology;Testing;Therapeutic;Tissues;Tracer;Training;translational goal;translational pipeline;Translational Research;Translations;United States National Institutes of Health


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

PHR: PI: Buelow, Hannes E.  Project Relevance  The functional asymmetry of human brains has long been known, but it only recently has it been appreciated that laterality of brain function is perturbed in neuropsychiatric disorders such as autism and other mental disorders. We have discovered an asymmetric neuronal connection in the small nematode Caenorhabditis elegans that is modulated by experience and hormonal signaling. We propose to study this asymmetric neuronal connectivity with a combination of genetic, behavioral, and imaging studies in C. elegans to explore the mechanisms of hormonal control of neuronal hardwiring.

PI_NAMEs: BUELOW, HANNES ERICH (contact)

PROJECT_TERMS: Adult;Afferent Neurons;Agonist;Anatomy;Animals;antagonist;Attention;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;behavioral study;Beta Cell;Bilateral;Biological Models;Biological Process;Brain;Brain imaging;Caenorhabditis elegans;Calcium;Cells;Cerebral Dominance;cognitive ability;Defect;Development;Electrons;Environment;Environmental Risk Factor;Exhibits;experience;experimental study;Exposure to;Foundations;Genetic;genetic manipulation;Genetic study;Genetic Transcription;Goals;Guanylate Cyclase;Heart;Hormonal;hormonal signals;Human;Image;imaging study;Individual;insight;Insulin;Insulin Receptor;insulin signaling;Ions;Knock-out;Label;Language;Left;Link;Liver;Locomotion;Measurable;Mediating;Mental Depression;Mental disorders;Microscopic;model organism;Molecular;Morphology;Nematoda;neural circuit;neural network;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;Neurosecretory Systems;optogenetics;Organ;Post-Traumatic Stress Disorders;programs;Psychology;receptor;receptor expression;receptor function;reconstruction;Research;Resolution;response;Role;Schizophrenia;Sensory;Shapes;Signal Pathway;Sodium Chloride;Space Perception;Stereotyping;Structure;Synapses;Taste Buds;Testing;Time;Transgenic Organisms;Translating;Translations;visual processing;Work

PROJECT_TITLE: Neuroendocrine Control of Synaptic Connectivity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


PI_NAMEs: CHUA, STREAMSON C (contact)

PROJECT_TERMS: Academy;Applications Grants;Area;Award;base;Budgets;Clinical;Collaborations;Communication;Communities;Complications of Diabetes Mellitus;Core Facility;Data;design;Development;Diabetes Mellitus;Discipline;Eligibility Determination;Ensure;experience;Extramural Activities;Faculty;Faculty Recruitment;feasibility research;Feasibility Studies;Fostering;Funding;Funding Agency;Future;Generations;Goals;Grant;Individual;Institution;interest;Investments;Laboratories;member;Mentors;Metabolic Diseases;Metabolism;Mission;Modality;Modeling;Monitor;New York;non-invasive imaging;novel;novel strategies;Obesity;obesity treatment;Pathway interactions;Pilot Projects;programs;Publications;recruit;Request for Applications;Research;Research Personnel;Research Project Grants;Science;Scientist;Services;success;Textiles;Translating;Translational Research;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Cancer Genome Project has revealed that chromatin factors are highly mutated in human cancers. Our proposed studies aim to understand how genomes distinguish non self sequences from self and how chromatin regulates ribosome assembly. The research will have the potential to reveal new mechanisms that will form base for understanding cancer cells.

PI_NAMEs: HALIC, MARIO  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;base;Biochemistry;Biogenesis;Biological Process;Biology;cancer cell;cancer genome;cell growth;Cell Nucleolus;Cells;Characteristics;Chromatin;chromatin protein;Chromatin Structure;Cryoelectron Microscopy;Data;Defect;DNA Sequence;DNA Transposable Elements;DNA-Binding Proteins;Elements;Environment;Eukaryotic Cell;Event;Evolution;fibrillarin;fighting;Fission Yeast;Genes;Genetic;genetic element;genetic information;Genetic Transcription;Genome;genome integrity;Genome Stability;genomic locus;Genomics;Goals;Heterochromatin;HMGN Proteins;Human;in vivo;Invaded;Knowledge;Lead;Liquid substance;Malignant Neoplasms;Mediating;Molecular Biology;Mutate;Mutation;next generation;nucleophosmin;Parasites;particle;Pathway interactions;Phase;physical separation;Positioning Attribute;prevent;Proliferating;Proteins;Regulation;Repetitive Sequence;Research;Ribosomal DNA;Ribosomal RNA;Ribosomes;RNA Interference;Role;Site;Sorting;Sterility;Structure;System;Tandem Repeat Sequences;Time;Transcriptional Silencer Elements;Work;Yeasts

PROJECT_TITLE: Chromatin of repetitive elements

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE (RELEVANCE) The proposed research is directly related to public health because understanding the molecular and cellular mechanisms of cell cycle regulation is expected to give rise to new types of diagnoses, treatments, and preventions for lung cancer and lung diseases. Thus, this study is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: PARK, JAE-IL  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Address;Attention;Biology;Bypass;Caenorhabditis elegans;Cancer Biology;cancer cell;cancer initiation;Cell Cycle;Cell Cycle Regulation;Cell Proliferation;Cells;Complex;Creativeness;Diagnosis;Dimerization;DNA biosynthesis;DNA Repair;Dreams;Drosophila melanogaster;Engineering;Epigenetic Process;Fostering;Gene Expression;Genes;genetic corepressor;Genetic Transcription;Genetically Engineered Mouse;Health protection;Human;in vivo;innovation;Lung;lung cancer prevention;Lung Diseases;lung regeneration;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mission;Mitotic;Modeling;Molecular;Molecular and Cellular Biology;Molecular Biology;mouse genetics;Multiprotein Complexes;Natural regeneration;Normal Cell;Pathologic;Physiological;Process;Proliferating;Proliferating Cell Nuclear Antigen;Proteins;Proteomics;Public Health;Repression;Research;Research Personnel;Resources;Role;Somatic Cell;stem;stem cell biology;stem cells;stemness;Testing;tissue injury;tissue regeneration;Transactivation;transcriptomics;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: PAF-Remodeled DREAM Complex in Cancer and Regeneration


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Dementia, including Alzheimer’s disease, is projected to pose a significant societal and financial burden to the U.S. healthcare system. This proposed study includes several conceptual and statistical innovations to address this burden. Our study will have a sustained and lasting impact on the field by generating the empirical evidence needed to clarify the role of waking and sleep behaviors on resilience to adverse cognitive outcomes in a well-characterized racially/ethnically diverse population of men and women.

PI_NAMEs: DIAZ, KEITH M (contact);GABRIEL, KELLEY PETTEE;PALTA, PRIYA

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Accelerometer;actigraphy;Activity Cycles;Address;adjudication;Adult;Age;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Ancillary Study;Asian;Behavior;Behavioral;behavioral phenotyping;Biological Markers;Black Populations;Black race;brain health;Calibration;Categories;Cause of Death;Cerebrovascular Disorders;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive function;cognitive performance;cognitive testing;Cohort Studies;Complex;cost;Data Analyses;Dementia;dementia risk;Devices;Disparity;Eligibility Determination;Enrollment;ethnic diversity;Ethnic Origin;Financial Hardship;Future;Goals;Guidelines;Health;Health behavior;Health Benefit;Healthcare Systems;High Prevalence;high risk;Hispanic;Hispanic Populations;Hour;Impaired cognition;Individual;innovation;instrument;Leisures;Light;light intensity;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Mediator;men;mild cognitive impairment;Minority Groups;Modeling;moderate-to-vigorous physical activity;Movement;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;Nerve Degeneration;neurofilament;new epidemic;Not Hispanic or Latino;Onset of illness;Outcome;Participant;Patient Self-Report;Pattern;Pharmacological Treatment;Physical activity;Plasma;Population Heterogeneity;Positron-Emission Tomography;preservation;Prevalence;prevent;Prevention strategy;prospective;protective factors;Protocols documentation;Public Health;Questionnaires;Race;racial diversity;Recommendation;Recording of previous events;Reporting;Research;research study;resilience;response;Risk;Role;screening;sedentary;sedentary lifestyle;sex as a biological variable;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Disorders;Sleep disturbances;tau Proteins;Time;United States;vigorous intensity;Woman;Work;β-amyloid burden

PROJECT_TITLE: Leveraging the 24-hour movement paradigm to preserve cognitive function and prevent Alzheimer's disease: The Multi-Ethnic Study of Atherosclerosis (MESA) 24H-ACT Study


ORG_CITY: SEATTLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Traumatic injury, infection and critical illness are important societal and health care concerns. Understanding the biology and applying new technologies as well as established methods are important to improving management and outcomes. In this renewal application, we focus on providing trainees with skills needed to become physician-scientists and experts in the techniques and skills that comprise systems biology and translational research.

PI_NAMEs: O'KEEFE, GRANT E (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: surgical research;Training Programs

PROJECT_TITLE: Surgery Research Training Program


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Helicobacter pylori infects half of the world’s population and is the strongest known risk factor for gastric cancer; however, traditional treatment with antibiotics is often ineffective, especially once precancerous lesions are present. We have previously shown that polyamines are involved in gastric inflammation and carcinogenesis, and our data indicate that the enzyme spermidine oxidase (SMOX) regulates key pathways involved in the progression to cancer. This project will investigate the mechanisms by which SMOX contributes to gastric carcinogenesis by examining its metabolic products, spermidine and the toxic metabolite acrolein, and the enhancement of a pathway involved in translation, hypusination, all of which could contribute to carcinogenetic signaling, with the ultimate goal of discovering novel pathways to be therapeutically targeted.

PI_NAMEs: MCNAMARA, KARA  (contact)

PROJECT_TERMS: Ablation;Acrolein;Adenocarcinoma;Adenocarcinoma Cell;Aldehydes;Amino Acids;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Atrophic Gastritis;Attenuated;Back;beta catenin;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Carcinoma;career;Catabolism;cell growth;Cells;Cessation of life;Chemicals;Chronic;Chronic Gastritis;Correa cascade;Critical Pathways;Data;deoxyhypusine monooxygenase;deoxyhypusine synthase;Development;Disease Progression;DNA Damage;Dysplasia;Enzymes;Epithelial Cells;Epithelium;Eukaryotic Initiation Factors;Exhibits;experimental study;Failure;Future;Gastric Adenocarcinoma;gastric cancer prevention;gastric carcinogenesis;Gastric Intraepithelial Neoplasia;Gastric mucosa;gastric organoids;Gastric Tissue;Gastrins;Gastritis;Generations;Gerbils;Goals;Gram-Negative Bacteria;Helicobacter Infections;Helicobacter pylori;Histologic;Human;hypusine;Immune response;Infection;Infection Control;Inflammation;inhibitor;Insulin;interest;Intestinal Metaplasia;Knockout Mice;Lesion;Macrophage;Malignant Neoplasms;malignant stomach neoplasm;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic;Metabolism;Metaplasia;mouse model;Mucosal Immune Responses;Mus;novel;novel strategies;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;Persons;polyamine oxidase;Polyamines;Population;Post-Translational Protein Processing;premalignant;Principal Investigator;Propanolamines;Protein Translation Pathway;Proteins;Proteomics;Publishing;Putrescine;Research;response;Risk;Risk Factors;Role;Signal Transduction;Spermidine;Spermine;Stomach;Stomach Carcinoma;Stomach Diseases;Supplementation;targeted treatment;Testing;therapeutic target;Tissues;Training;transcriptome;Transgenic Organisms;translational goal;Translations;tumorigenesis;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: Polyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric Carcinogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

PHR: NARRATIVE Abnormal formation and recall of stress-related memories have been linked to the development of affective disorders, including anxiety, depression, and stress-related disorders, which are the most prevalent psychiatric illnesses in the US and worldwide. We propose to establish a hitherto unrecognized role of inflammation- related signaling pathways in the long-term representation of such memories in specialized brain circuits. These pathways and circuits can serve as candidate targets for novel treatments of neuropsychiatric disorders rooted in episodic memory deficits.

PI_NAMEs: RADULOVIC, JELENA  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: activity marker;Affect;Anxiety;Area;Behavioral;Biochemical;Biological;Brain;candidate identification;Cells;cognitive function;conditional knockout;conditioned fear;Data;Decision Making;Dementia;Dependence;design;Development;Disease;DNA;Dorsal;Ensure;episodic like memory;Episodic memory;experience;Extracellular Matrix;Fright;Functional disorder;Gene Expression Profile;Genetic;genetic manipulation;Hippocampus;Hour;Impairment;in vivo;Induced Neurons;Inflammation;Inflammation Mediators;Inflammatory;knock-down;Knowledge;Label;Link;LoxP-flanked allele;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;Mental Depression;Mental disorders;Modeling;Modification;Molecular;Monitor;Mood Disorders;mouse model;Mus;Nature;Neocortex;neocortical;neurobiological mechanism;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Pattern;Pilot Projects;Population;Post-Traumatic Stress Disorders;postsynaptic;postsynaptic neurons;preservation;presynaptic;presynaptic neurons;Process;Publishing;Qualifying;Receptor Signaling;Reporter;Research;Retrieval;Rodent;Role;Signal Pathway;Signal Transduction;Site;Stress;stress related disorder;Synapses;System;targeted treatment;Testing;Time;TLR9 gene;Toll-like receptors;Training;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Variant;Viral

PROJECT_TITLE: Cortico-hippocampal mechanisms of context memory


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The proposed research will apply transcutaneous vagus nerve stimulation, a non-invasive brain stimulation method that modulates a system in the brain that is initially affected by Alzheimer's disease pathology and enhances memory performance, and thus may hold the key to successfully delay this disease in its earliest stages. We will assess the duration and extent of improvements in cognitive performance, and will identify individual, brain physiology and Alzheimer's disease-related factors that contribute to its success in older individuals without clinical impairment, including those at risk for Alzheimer's disease. This project has important public health implications as it gathers critical information to identify the target population, and to inform designs of future clinical trials aimed at prevention of Alzheimer's disease.

PI_NAMEs: JACOBS, HEIDI IRMA (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: abeta accumulation;Acute;Address;Affect;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Animals;apolipoprotein E-4;Behavioral;Biological;Biological Markers;Blood specimen;blood-based biomarker;Brain;Brain Stem;Cell Nucleus;Characteristics;Clinical;Clinical Trials;Cognitive;cognitive change;cognitive performance;cognitive testing;cost;Crossover Design;Dedications;demographics;design;Disease;Disease Progression;Double-Blind Method;Education;Eligibility Determination;Enrollment;Exhibits;Exposure to;Face;Female;follow-up;Functional Magnetic Resonance Imaging;Future;Genetic;Goals;Image;Impaired cognition;Impairment;improved;Individual;Individual Differences;Inflammation;inflammatory modulation;Inflammatory Response;innovation;Intervention;Intractable Epilepsy;locus ceruleus structure;Long-Term Effects;Long-Term Potentiation;Measures;Memory;Methodology;Methods;molecular marker;Monitor;Names;Nerve;Nerve Degeneration;neural;neuroimaging;neurophysiology;Neuropsychological Tests;noninvasive brain stimulation;Norepinephrine;Older Population;Outcome;Outcome Measure;Participant;Pathology;Pathway interactions;Patients;Performance;Phase;Physiology;Population;pre-clinical;predictive marker;Preventive;preventive intervention;primary outcome;Property;Public Health;Randomized;randomized trial;randomized, clinical trials;Research;Research Personnel;respiratory;responders and non-responders;response;Risk;secondary outcome;Series;sex;Site;Stratification;success;System;Target Populations;tau Proteins;Testing;Time;vagus nerve stimulation;Validation;Work

PROJECT_TITLE: The wandering nerve: gateway to boost Alzheimer's disease related cognitive performance

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Digestive Diseases;Health Services;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE There is substantial variability in patient outcomes after hospitalization for gastrointestinal bleeding (GIB) across hospitals. Patient-related factors, hospital structure and processes of care play major roles in determining outcomes for many other diseases, but the impact of these factors on outcomes related to GIB has not been adequately defined. This novel proposal will evaluate the effect of patient-level factors to generate risk-standardized rates of GIB outcomes across hospitals and to identify modifiable hospital-level factors using a mixed methods approach to study comprehensively how modifiable factors are associated with better outcomes.

PI_NAMEs: SIDDIQUE, SHAZIA MEHMOOD (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Accounting;Acute;American Hospital Association;Anticoagulation;Beds;Calibration;career development;Caring;Characteristics;Clinical;clinical application;Clinical Pathways;Clinical Practice Guideline;cohort;comorbidity;Data;Data Analytics;Data Set;Databases;Death Rate;Development;Development Plans;Discrimination;Disease;Endoscopy;Enrollment;Ensure;Epidemiology;Evaluation;experience;Faculty;Foundations;Funding;Gastrointestinal Hemorrhage;Goals;Grant;Health Care Reform;Health Policy;Health Services Research;Health system;Heterogeneity;hospital performance;Hospitalization;Hospitals;improved;improved outcome;inpatient service;Inpatients;Institution;Interventional radiology;Interview;K-Series Research Career Programs;Learning;Length of Stay;Link;Master of Science;Measures;Medicare;Medicare claim;Mentors;Mentorship;Methodology;Methods;Modeling;mortality;multilevel analysis;novel;Nurses;organizational structure;Outcome;Outcome Measure;Outpatients;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Physicians;Play;Population Heterogeneity;Procedures;Process;Process Measure;Provider;Qualitative Methods;readmission rates;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Scientist;skills;Source;Standardization;Statistical Methods;stem;Structure;Surveys;Training;United States;United States National Institutes of Health;Validation;Variant

PROJECT_TITLE: Evaluation of variability in care and outcomes for patients with gastrointestinal bleeding

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

PHR: PROJECT NARRATIVE Nearly 25% of all pediatric and adult cancers have damaging mutations in the genes that encode SWI/SNF chromatin remodeling complex subunits, but our understanding of how these mutations cause cancer is quite limited. This proposal investigates a relatively understudied gene that aggressive pediatric cancers with mutations in this complex depend on for survival. Collectively, these studies will offer insight into how damaging mutations in this complex cause cancer, reveal new ways chromatin function is regulated, and potentially identify a new therapeutic target in this aggressive pediatric cancer.

PI_NAMEs: MALONE, HAYDEN ABIGAIL (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Ablation;Acetylation;Acetyltransferase;Address;Adult;Alleles;Automobile Driving;Binding;Binding Proteins;Biochemical;Biology;Cancer cell line;Cancer Etiology;cancer genome;Cells;Chemicals;Child;Childhood;Chromatin;Chromatin Remodeling Factor;Complex;CRISPR screen;Data;Dependence;design;Diploidy;Disease;Enhancers;experimental study;Gene Expression;Genes;Genetic Transcription;genome-wide;Germ-Line Mutation;Goals;Histone Acetylation;Histones;Infant;inhibitor;insight;Lysine;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;member;Mentors;Mitosis;mutant;Mutate;Mutation;neoplastic cell;Neurodevelopmental Disorder;new therapeutic target;novel;Nucleosomes;Outcome;overexpression;PH Domain;pharmacologic;Post-Translational Protein Processing;preservation;Prognosis;promoter;Proteins;Publishing;Reader;recruit;Regulation;Reporting;Rhabdoid Tumor;Role;scaffold;Site;SMARCB1 gene;Soft Tissue Neoplasms;Study models;SWI/SNF Family Complex;therapeutic target;Training;Transcriptional Regulation;Tumor Cell Line;ubiquitin ligase;Writing

PROJECT_TITLE: Investigating essential chromatin regulators in cancers with SWI/SNF mutations


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Fusion-Negative Rhabdomyosarcoma is an aggressive pediatric soft tissue sarcoma. Although there are current treatments available, the event-free survival rate is still below 30%. This proposal seeks to delineate the role of the ecto 5’-nucleotidase (NT5E) enzyme in this tumor, with the goal of developing novel therapeutic strategies.

PI_NAMEs: CANO HERNANDEZ, KARLA GABRIELA (contact)

PROJECT_TERMS: 5'-Nucleotidase;Adenosine;Adenosine Monophosphate;ADORA2A gene;Affect;Agonist;AKT Signaling Pathway;Balanced Chromosomal Translocation;Binding;Binding Sites;blocking factor;Categories;Cell Differentiation process;cell growth;Cell Surface Proteins;Cells;Chemicals;Chemotherapy and/or radiation;Childhood Soft Tissue Sarcoma;Chimeric Proteins;ChIP-seq;Development;Disease-Free Survival;Doxycycline;driver mutation;Enzymes;Event;FOXO1A gene;gain of function;Genes;Genetic Transcription;Genome;Goals;Growth;Human;improved;In Vitro;in vivo;inhibitor;insight;Invaded;knock-down;Knowledge;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Melanoma;Molecular;mouse model;Muscle;mutant;Mutation;Myoblasts;myogenesis;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;Nucleotidases;Oncogenic;Operative Surgical Procedures;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenocopy;Phenotype;PI3K/AKT;prevent;Primary carcinoma of the liver cells;Production;programs;Proteins;Purinergic P1 Receptors;Recurrence;Regulation;Repression;Research;Rhabdomyosarcoma;Role;Signal Pathway;Survival Rate;System;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome sequencing;tumor;tumor growth;tumor progression;WNT Signaling Pathway;Xenograft procedure

PROJECT_TITLE: The Molecular function of ecto 5' nucleotidase in fusion-negative rhabdomyosarcoma


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: The identification of cellular and molecular mediators of axon injury during demyelination is critical to understanding and preventing the loss of function associated with disease progression in patients with multiple sclerosis. The proposed research is relevant to public health because the discovery that demyelinated axons are injured by CD8+ T cells directed against neuron-specific antigens and the discovery that such anti-axonal T cells are found in patients with multiple sclerosis will reveal new therapeutic strategies for intervention in these patients. The proposed research is relevant to the mission of the NIH and NINDS because it will develop fundamental knowledge that may help reduce the burden of disease and improve human health.

PI_NAMEs: HOWE, CHARLES LEE (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Address;adeno-associated viral vector;Adoptive Transfer;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Autoimmunity;Autologous;Automobile Driving;Axon;axon injury;Blood;Brain;burden of illness;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clonal Expansion;Coupled;Cuprizone;cytotoxic CD8 T cells;Defect;Demyelinating Diseases;Demyelinations;disability;Disease;Disease Progression;Disease remission;Effector Cell;Engineering;Evolution;Exhibits;Experimental Autoimmune Encephalomyelitis;experimental study;Fibroblasts;functional disability;Genes;Goals;Health;Histocompatibility Antigens Class I;Human;Immunization;improved;Induced pluripotent stem cell derived neurons;Infiltration;Inflammation;Injury;innovation;Intervention;Ion Channel;Knowledge;loss of function;Lymphocyte;Measures;Mediating;Mediator;MHC Class I Genes;Microfluidics;Mission;Modeling;Molecular;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Mus;National Institute of Neurological Disorders and Stroke;neoantigens;Nervous System Physiology;neuroinflammation;Neurons;novel;novel therapeutic intervention;oligodendrocyte-myelin glycoprotein;OVA-8;Ovalbumin;Pathogenesis;Pathogenicity;Patients;Peptides;Peripheral;Population;prevent;Proliferating;Public Health;recruit;Relapse;remyelination;Research;Resolution;response;Role;Secondary to;Specificity;Symptoms;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;therapy development;Time;Toxic effect;trafficking;Transgenic Organisms;United States National Institutes of Health;Work

PROJECT_TITLE: Neuronal antigen surveillance and autoimmunity in CNS demyelinating disease


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PHR: PROJECT NARRATIVE Metastatic breast cancer is a serious and often fatal disease for which effective treatments are not yet available. This study investigates the role of epithelial cell adhesion molecule (EpCAM) N-glycosylation in facilitating breast cancer metastasis and changes in the N-glycosylation profile of EpCAM in metastasizing cancer cells in mouse models of breast cancer. This work is significant because it will elucidate the role of EpCAM N-glycosylation in breast cancer metastasis and may provide insight into novel treatment strategies for metastatic breast cancer.

PI_NAMEs: JENKINSON, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adhesions;Affect;Basement membrane;Biochemistry;Biological Assay;Biomedical Engineering;Blood Vessels;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Biology;cancer cell;Carcinoma;career development;Caring;Cell Adhesion;Cell Adhesion Molecules;Cell Line;Cells;Cellular biology;Cessation of life;Colorectal Cancer;Committee Members;Complement;Complex;Correlation Studies;CRISPR/Cas technology;Cycloheximide;Data;Development;Digestion;Disease;Distant;Distant Metastasis;DNA;doctoral student;Education;Educational workshop;effective therapy;Epithelial Cells;experience;experimental study;Female;Generations;Glycobiology;Glycopeptides;glycosylation;Goals;Growth;Human;immunodeficiency;Immunoprecipitation;in vitro Assay;in vivo;insight;interest;Invaded;Investments;knock-down;Knock-out;Link;liquid chromatography mass spectrometry;Liver;Lung;lymph nodes;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;mammary epithelium;Mammary Neoplasms;Mannose;mass spectrometric imaging;Mass Spectrum Analysis;MDA-MB-468;meetings;member;Mentors;Mentorship;Metastatic breast cancer;Metastatic Neoplasm to Lymph Nodes;Microscopic;migration;Molecular Biology;mouse model;mRNA Expression;Mus;mutant;Mutate;N-Glycosylation Site;nano-liquid chromatography;Neoplasm Metastasis;new therapeutic target;Nodule;Normal tissue morphology;novel;Nude Mice;overexpression;Pathologist;Patients;Pattern;Peptides;Physicians;Polysaccharides;Post-Translational Protein Processing;Pre-Clinical Model;Primary Neoplasm;programs;Property;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Role;Sampling;Scientist;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;success;Survival Rate;symposium;Techniques;Testing;Tissues;Training;treatment strategy;triple-negative invasive breast carcinoma;Trypsin;tumor growth;tumor metabolism;Tumor Tissue;tumor xenograft;undergraduate student;United States;Universities;Widespread Disease;Woman;Work;Writing;Xenograft Model

PROJECT_TITLE: The Role of EpCAM Glycosylation in Breast Cancer Metastasis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Overall: Project Narrative The Koch Institute for Integrative Cancer Research at MIT is a highly inter-disciplinary Cancer Center that brings together the great strengths at MIT in cancer science and cancer-oriented engineering to address long- standing problems in the diagnosis and treatment of cancer. The Koch Institute is focused on basic discovery and technology development; however, advancing projects toward the clinic and to the benefit of patients as rapidly as possible is a high priority. This occurs through extensive interactions with clinical centers as well as industry partners.

PI_NAMEs: VANDER HEIDEN, MATTHEW G. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;anti-cancer research;base;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Science;cancer therapy;Clinic;clinical center;Collaborations;Core Facility;Data;Development;Diagnosis;Engineering;Environment;Evaluation;Faculty Recruitment;Fostering;Funding;Genetic;Grant;improved;industry partner;Infrastructure;innovation;Institution;Investments;Laboratories;Love;Malignant Neoplasms;member;National Cancer Institute;NCI Center for Cancer Research;neoplasm resource;Patients;Pilot Projects;programs;Publishing;recruit;Research;research and development;Research Infrastructure;Research Support;Schools;Science;Scientist;System;technology development;Translational Research;tumor immunology

PROJECT_TITLE: Cancer Center Support (Core) Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: O'CONNELL, ANDREEA  (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Cancer Center;Cancer Center Support Grant;Communities;Core Facility;Databases;Development;Ensure;Environment;Event;Faculty;Faculty Recruitment;Fellowship;Financial Support;Funding;Funding Mechanisms;Grant;Guidelines;Health;Human Resources;Knowledge;Laboratories;Leadership;Link;Maintenance;Malignant Neoplasms;Marble;meetings;member;Mentors;molecular oncology;nanomedicine;Office Management;operation;Organizational Policy;Pilot Projects;precision oncology;Process;programs;Publications;Research;Safety;Services;stem cells;Structure;Support System;System

PROJECT_TITLE: Administrative Core