NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE. The focal point of this project is to decode the cellular and molecular mechanisms that regulate the metabolic reprogramming occurring in glioma and the tumor microenvironment, which is one of the major mechanisms contributing to tumor progression. I propose to investigate how pH-dependent metabolic pathways contribute to glioma growth and glioma-vascular interaction. These studies aim to uncover new regulatory mechanisms of glioma metabolism and glioma-vascular metabolic communication, offering potential avenues for the identification of therapeutic targets.

PI_NAMEs: YE, QI  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Acidity;Acidosis;Address;Advisory Committees;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;APLN gene;Bicarbonates;Binding Proteins;Biology;Blood Vessels;Brain Injuries;Brain Neoplasms;bridge program;Cell Shape;Cerebrovascular system;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Coupled;Data;Databases;Dedications;Endothelium;extracellular;fatty acid-binding proteins;Foundations;Functional disorder;gain of function;gene discovery;Genes;genetic signature;Glioblastoma;Glioma;Gliomagenesis;gliovascular;Goals;Growth;Histology;Human Genetics;Image;Immunocompetent;improved;Injury;insight;Invaded;Knockout Mice;Knowledge;Letters;Link;Lipid Binding;lipid metabolism;Lipids;loss of function;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mentors;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;multiple omics;Mus;mutant;neoplastic cell;Neuroglia;overexpression;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Phase;Prognosis;Proliferating;Regulation;Research;response;Role;Shapes;Sodium-Bicarbonate Symporters;Survival Analysis;symporter;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Training Support;transcriptomic profiling;tumor;Tumor Angiogenesis;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Validation;Vascular Endothelium;Vascular remodeling

PROJECT_TITLE: Deciphering the role of pH regulator Slc4a4 in glioma progression

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Nuclear speckles are distinct compartments within the cell’s nucleus that regulate turning genes on or off and are composed of several different proteins and RNA. Genes are successfully turned on only when specific proteins reach the right location in the nucleus at the right time. I propose to develop tools to discover how proteins in the nuclear speckles assemble with their partner RNA and achieve the correct placement of the proteins and RNA.

PI_NAMEs: SHINN, MIN KYUNG  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affect;Amino Acid Sequence;Architecture;Award;Behavior;Binding;Binding Proteins;Biochemical;Bioinformatics;biophysical model;Biophysics;breast cancer progression;Cell Nucleus;Cells;Cellular Stress;Chemicals;Complex;Computational Biology;Computer Analysis;Computer Simulation;copolymer;Cytoplasm;cytotoxic;Data;Dependence;Development;Disease;Emulsions;Evolution;experimental study;Gene Expression;Genes;Genetic Transcription;Goals;Grant;Human;hydrophilicity;Hydrophobicity;Hypoxia;Impairment;In Vitro;in vivo;Individual;insight;intein;Investigation;Length;Location;Maintenance;MALAT1 gene;Malignant Neoplasms;Micelles;Microscopy;Modeling;Modernization;Molecular;Morphology;mRNA Precursor;Neurodevelopmental Disorder;Nuclear;Nuclear Matrix;Nuclear Proteins;Phase;Physical condensation;Production;Protein Family;Proteins;reconstitution;Reporting;Repression;Research;response;Ribonucleoproteins;RNA;RNA Binding;RNA Recognition Motif;RNA Splicing;RNA Transport;RNA-Binding Proteins;scaffold;segregation;Spectrum Analysis;Spliceosomes;Stress;stress granule;System;Territoriality;Testing;Therapeutic;Time;tool;Training Support;Transcript;Variant;Virus Diseases

PROJECT_TITLE: Uncovering the Molecular Principles for Microphase Separation by Nuclear Speckle Proteins and RNA Transcripts

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (KR)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Characterizing the Function of Cyclic di-AMP on Chlamydial Growth and Differentiation Chlamydiae are important pathogens of humans and significant causes of morbidity, causing a range of illnesses including sexually transmitted diseases, trachoma, pneumonia, and other respiratory tract infections. In addition, these bacteria undergo a unique developmental cycle that is essential for their growth and ability to cause disease. The work proposed here is to identify the function of a compound produced by the bacterium and how it regulates its growth and developmental cycle.

PI_NAMEs: OUELLETTE, SCOT P (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Bacteria;Binding;Binding Proteins;Binding Sites;biological adaptation to stress;Biological Assay;Biology;Blindness;Blood capillaries;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chronic;comparison control;Complex;Complication;CRISPR interference;Data;Dependence;Developed Countries;Developing Countries;Development;Developmental Course;Differentiation and Growth;Dinucleoside Phosphates;Disease;Elements;environmental change;Exclusion;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Techniques;Genome;Genus Mycobacterium;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;Growth and Development function;Healthcare Systems;Homeostasis;Human;human pathogen;Immune signaling;In Vitro;in vivo;Incidence;Ions;knock-down;Ligands;Link;Mass Spectrum Analysis;Metabolic;Morbidity - disease rate;Morphology;mutant;novel;Organism;overexpression;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pelvic Inflammatory Disease;Periodicity;Permeability;Physiology;Pneumonia;Production;Promoter Regions;Protein Isoforms;Proteins;Radial;Reiter Disease;Reporting;Respiratory Tract Infections;Ribosomes;Second Messenger Systems;Sexually Transmitted Diseases;Signal Pathway;Signal Transduction;System;Techniques;therapeutic target;tool;Trachoma;transcriptome sequencing;tubal infertility;Virulence;Work

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposal aims to establish robust phenotyping pipelines for early detection of Collagen Type IV-Associated Nephropathy (COL4A-AN) using electronic health record (EHR) data. To overcome diagnostic challenges of this prevalent monogenic form of chronic kidney disease (CKD), the study focuses on utilizing Natural Language Processing (NLP) to extract nuanced phenotypic traits from unstructured clinical narratives and build accurate and portable prediction models. These models lay the foundation for developing effective EHR-based decision support tools that enable clinicians to identify patients with genetic CKD subtypes, even when unfamiliar with specific genetic syndromes.

PI_NAMEs: NESTOR, JORDAN GABRIELA (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: accurate diagnosis;Address;adjudication;Affect;Automated Clinical Decision Support;biobank;Chronic Kidney Failure;Clinical;clinical phenotype;Clinical Trials;cohort;Collaborations;Collagen Type IV;Complex;Data;data interoperability;data mining;data modeling;data quality;data standards;Dedications;design;Development;Diagnosis;Diagnostic;digital tool;Disease;Disease Management;Disease Outcome;Disease Progression;Disease Surveillance;disorder subtype;Early Diagnosis;Economic Burden;Electronic Health Record;electronic structure;Eligibility Determination;exome sequencing;experience;experimental study;Face;Fostering;Foundations;Funding;Future;Genetic;Genetic study;genetic testing;Genomics;Goals;Health;Health system;Healthcare;heterogenous data;improved;Individual;individualized medicine;Institution;International Classification of Disease Codes;interoperability;Intervention;Jordan;Kidney Diseases;Kidney Failure;Knowledge;Language;Medical;Mendelian disorder;Mentors;Mining;Modeling;Natural Language Processing;Nephrology;open source;Other Genetics;Outcome;Patient Care;Patients;Performance;personalized intervention;Phenotype;phenotypic data;point of care;portability;precision medicine;predictive modeling;prospective;Reproducibility;Research;Research Personnel;Running;Semantics;Source;Standardization;Structure;structured data;support tools;Syndrome;System;Terminology;Testing;Text;Training;trait;Unified Medical Language System;United States National Institutes of Health;Universities;unstructured data;Validation

PROJECT_TITLE: Digital Tools for Precision Nephrology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative Hematopoietic stem cell transplantation (HSCT) with autologous gene therapy is a promising approach to treating non-malignant blood diseases; however, optimization of stem cell mobilization, transplant conditioning regimens, and stable engraftment of gene-edited hematopoietic stem cells is essential to maximizing the curative potential of HSCT. This proposal seeks to overcome these major barriers by investigating novel stem cell mobilization and antibody-based transplant conditioning strategies and leveraging these approaches to improve therapy of sickle cell disease. These studies will yield novel insights that will advance the basic science and translational potential of autologous gene therapy.

PI_NAMEs: PERSAUD, STEPHEN PHILLIP (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Academic Medical Centers;adaptive immunity;Allogenic;Anemia;Anti-CD47;Antibodies;Antibody-drug conjugates;Area;Autologous;Autologous Transplantation;Basic Science;Biology;Bispecific Antibodies;career;career development;CD34 gene;CD47 gene;Cells;Cellular immunotherapy;chemotherapy;Chimerism;Clinical;Clinical Pathology;conditioning;CSF3 gene;CXCR4 gene;Dedications;Development;Development Plans;Disease;Doctor of Philosophy;efficacy evaluation;Engraftment;Ensure;Environment;Erythrocytes;Exposure to;fertility preservation;follower of religion Jewish;gene therapy;Genes;Genetic;Goals;Graft Rejection;graft vs host disease;Harvest;Hematological Disease;Hematopoiesis;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;Hospitals;Immunologics;Immunology;Immunotherapeutic agent;improved;inhibitor;Injury;insight;Integrin alpha4beta1;irradiation;JAK1 gene;leukemia treatment;Life Expectancy;Major Histocompatibility Complex;Malignant - descriptor;medical schools;Medicine;Mentors;Methods;Modification;mouse model;Mus;Myelogenous;Nature;Non-Malignant;novel;novel strategies;Oncology;Opportunistic Infections;Outcome;Pathology;patient population;Patients;peripheral blood;Peripheral Blood Stem Cell;physician-scientist training program;Physicians;Postdoctoral Fellow;pre-clinical;Predisposition;preservation;Production;programs;PTPRC gene;Publishing;Quality of life;Regimen;Research;research and development;Research Personnel;Residencies;Resources;restoration;Safety;Scientist;screening;Sickle Cell Anemia;Signal Transduction;standard of care;Stem Cell Mobilization;Stem cell transplant;stem cells;Streptavidin;systemic toxicity;T-Lymphocyte;tenure track;Therapeutic;therapeutic genome editing;Time;Toxic effect;Toxin;Training;translational potential;Transplant Recipients;Transplantation;Transplantation Conditioning;Universities;Washington;Work

PROJECT_TITLE: Optimizing hematopoietic stem cell transplantation to treat non-malignant disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This study will explore the experiences of Black/African American fathers/male partners and couples with perinatal care, highlighting elements of positive experiences and challenges encountered. Results will provide a comprehensive understanding of the experiences of Black parents. Study findings will provide information on specific elements of Black parents’ interactions with perinatal care processes, and describe the potential role of fathers as allies in perinatal care.

PI_NAMEs: ALIO, PAULA AMINA (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Advocate;African American;African American Women;Ally;Area;Birth;Birth Weight;Black race;black women;care systems;Caring;Categories;Child;Cities;Communities;community engaged approach;community engagement;community organizations;County;Couples;Data;Data Analyses;Data Collection;design;Disparity;Elements;Emotional;Ensure;Equity;experience;Family;father role;Fathers;Financial Support;Fingers;Funding;Goals;Healthcare Systems;improved;Individual;Infant;infant outcome;innovation;Institution;Intervention;Interview;Literature;male;Maternal Behavior;maternal morbidity;Maternal Mortality;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;New York;Outcome;Parents;Patients;Perception;Perinatal Care;perinatal health;perinatal period;Persons;Policies;Postpartum Period;Pregnancy;Pregnancy Outcome;Prenatal care;Process;programs;racial disparity;Research;Research Personnel;Rest;Role;service delivery;service programs;Service provision;severe maternal morbidity;smoking cessation;social;social factors;Source;structural determinants;Testing;White Women;Woman;Work

PROJECT_TITLE: A community engaged approach to understanding Black fathers' experiences with perinatal care

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Lewy body dementia (LBD) accounts for up to 10% of all dementia patients. This project is to test the hypothesis that the velocity-selective arterial spin labeling based cerebral blood perfusion pattern is a reliable non-contrast MRI biomarker for LBD that predicts long term cognitive impairment and dementia outcomes.

PI_NAMEs: ZHU, DAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;arterial spin labeling;Arteries;Biological Markers;blood perfusion;Brain;Cerebrovascular Circulation;Cerebrum;clinical application;Clinical Research;Cognitive;cognitive function;cognitive testing;Contrast Media;cost;Data;Dementia;Dementia with Lewy Bodies;Deposition;detection sensitivity;Development;Disadvantaged;Disease;Distant;Early Diagnosis;Elderly;Ensure;evaluation/testing;experimental study;Fingers;General Population;Goals;Head;Head Movements;healthy volunteer;hemodynamics;hypoperfusion;Image;imaging biomarker;Immunity;Impaired cognition;improved;Incidence;Individual;intravenous injection;Investigation;Levodopa;Lewy Bodies;Lewy Body Dementia;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Methods;mild cognitive impairment;Monitor;Morphologic artifacts;Motion;Movement;Multi-site clinical study;Nerve Degeneration;neuroimaging marker;non-motor symptom;Occipital lobe;Oral Administration;Outcome;Parietal;Parietal Lobe;Parkinson Disease;Parkinson's Dementia;Patients;Pattern;Perfusion;perfusion imaging;Pharmaceutical Preparations;Positron-Emission Tomography;Proteins;Protocols documentation;Recommendation;reconstruction;Reproducibility;Research;response;side effect;Signal Transduction;single photon emission computed tomography;Standardization;Techniques;Temporal Lobe;temporal measurement;Testing;Time;Vendor

PROJECT_TITLE: Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The rapidly growing population of older incarcerated adults in the United States is at high-risk for delirium due to higher rates of known delirium risk factors and incarceration-specific risk factors, such as accelerated aging and decreased delivery of evidence-based delirium prevention measures in the hospital. Because there is virtually no data on delirium in this population, this project aims to establish foundational data on delirium epidemiology (including prevalence, incidence, and risk factors), on the frequency of delivery of evidence- based delirium prevention measures (e.g. cognitive stimulation, ambulation), and on potential barriers and facilitators to delivery of those measures. The definitive goal of this work is to design, test, and implement an incarceration-specific approach to evidence-based delirium measures that will reduce the risk of delirium in the marginalized and high-risk population of older incarcerated adults.

PI_NAMEs: KAIKSOW, FARAH ACHER (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Adult;Age;age acceleration;Aging;aging population;Award;Behavior Therapy;career;Caring;Clinical;Cognitive;comorbidity;correctional system;Data;Delirium;Dementia;design;Diagnosis;Documentation;Elderly;Environment;Epidemiology;evidence base;experience;Face;Foundations;Frequencies;Functional impairment;Future;Geriatrics;Goals;health disparity;high risk;high risk population;hospital care;Hospitalization;Hospitals;Impaired cognition;Imprisonment;improved;Incidence;Individual;Inpatients;Intervention;Interview;K-Series Research Career Programs;Knowledge;marginalization;marginalized population;Measures;medical schools;Mental Health;Mentorship;Methods;Morbidity - disease rate;mortality;multidisciplinary;novel;older adult;Older Population;patient-level barriers;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Precipitating Factors;Prevalence;Prevention;Prevention approach;Prevention Measures;Prisons;programs;prospective;Prospective Studies;Provider;provider-level barriers;Public Health;Recommendation;Records;Research;Research Design;Research Personnel;Resources;restraint;Risk;Risk Factors;Risk Reduction;Science;Scientist;screening;Severity of illness;Shapes;Site;skills;Structure;Syndrome;system-level barriers;tertiary care;Testing;Training;United States;Universities;virtual;Wisconsin;Work

PROJECT_TITLE: Hospital delirium in the rapidly aging incarcerated population

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M4)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Diabetes;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Wound Healing and Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Diabetic wound infections are a major medical burden, as they are difficult to treat due to an improper immune response and the presence of dangerous bacterial pathogens. This proposal will investigate key aspects of the diabetic wound environment including the immune response, hyperglycemia, and polymicrobial interactions to provide insight into why many patients have poor healing outcomes. These studies seek to more fully understand the molecular mechanisms by which bacteria evade the diabetic immune system in this environment to inform more targeted therapeutic approaches.

PI_NAMEs: KEOGH, REBECCA  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Affect;Amputation;Antibiotic Resistance;Automobile Driving;Bacteria;Cell Physiology;Cells;Chronic;clinically relevant;co-infection;combat;Complex;Complications of Diabetes Mellitus;Dangerousness;Data;Development;Diabetes Mellitus;diabetic;diabetic ulcer;endonuclease;Environment;Environmental Risk Factor;Exhibits;extracellular;Extracellular Matrix;feeding;Functional disorder;Genes;Genetic Transcription;global health;Glucose;Goals;healing;Hyperglycemia;Immune;Immune Evasion;Immune response;Immune system;Immune System Diseases;Impairment;in vivo;Individual;Infection;Inflammation;inflammatory milieu;insight;Lower Extremity;Medical;Metabolic;Microbial Biofilms;Modeling;Molecular;mouse model;Mus;neutrophil;non-diabetic;non-healing wounds;Nutrient;Nutritional Immunity;Operative Surgical Procedures;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Patients;Phagocytosis;Predisposition;prevent;Public Health;Shapes;Staphylococcus aureus;Streptococcal Infections;Streptococcus Group B;success;targeted treatment;transcriptome;transcriptome sequencing;transposon sequencing;Virulence;wound;wound closure;wound environment;wound healing;Wound Infection

PROJECT_TITLE: The Diabetic Wound Environment Shapes Group B Streptococcal Pathogenesis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Palliative Care

PHR: PROJECT NARRATIVE This project is relevant to public health through the development of a new geriatric palliative care delivery model with potential to improve serious illness communication, decision-making, and goal-concordant care for hospitalized older adults with advanced cancer discharged to skilled nursing facilities. This proposal is consistent with the National Institute on Aging’s mission to develop effective strategies to improve the interaction and experience of older adults near the end of life with the health system and to identify ways to support family caregivers. This work has the potential to impact the health of an increasing number of aging adults with serious illness and poor prognosis being discharged to skilled nursing facilities after an acute care hospitalization.

PI_NAMEs: SINGH, SARGUNI  (contact)

PROJECT_TERMS: Acceleration;acute care;Address;Adherence;Adult;Advance Care Planning;Advanced Malignant Neoplasm;Affect;Aging;arm;beneficiary;cancer therapy;cancer type;care delivery;care preference;Caregiver Burden;Caregivers;caregiving research;Caring;Cessation of life;Characteristics;Clinical;clinical efficacy;Clinical Trials;Clinical Trials Design;Collection;Colorado;Communication;Communities;comorbidity;coping;Data;Decision Making;design;Development;Distress;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Elderly;end of life;end of life care;end-of-life decision making;Enrollment;experience;Family;Family Caregiver;family support;feasibility testing;Feedback;follow-up;functional gain;Funding;Future;Goals;Guidelines;Health;Health care facility;Health system;high risk;Home;Home Nursing Care;hospice environment;hospice utilization;hospital readmission;Hospitalists;Hospitalization;Hospitals;Immunotherapy;implementation evaluation;implementation outcomes;implementation science;improved;Individual;Intervention;intervention delivery;intervention refinement;Interview;Lead;Length of Stay;Malignant Neoplasms;Manuals;Measures;Medicare;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;Modeling;Morbidity - disease rate;mortality;National Institute on Aging;novel;novel strategies;Nursing Homes;older adult;older patient;Oncology;Outcome;Palliative Care;Palliative Care Nursing;Participant;participant enrollment;patient oriented;Patient Outcomes Assessments;Patient Preferences;Patient-Centered Care;Patient-Focused Outcomes;Patients;Perception;person centered;Physicians;pilot trial;Population;Positioning Attribute;preference;Preparation;Process;Prognosis;Public Health;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;Service delivery model;Skilled Nursing Facilities;skills;Social Work;Social Workers;surrogate decision maker;surrogate decision making;Surveys;Syndrome;System;Testing;theories;therapy development;Training;treatment as usual;Universities;virtual;virtual assessment;Visit;Work

PROJECT_TITLE: Improving Person-Centered Outcomes for Older Adults with Cancer Discharged to Skilled Nursing Facilities and their Family Caregivers

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pontocerebellar Hypoplasia Type 1b (PCH1b) is a devastating inherited neurological disorder that preferentially affects specific regions of the brain, the pons and the cerebellum, causing children born with this condition to have dramatically reduced lifespans. The mutations that cause PCH1b occur in a gene that encodes a critical component of a molecular machine that is important for the regulation of gene expression. The proposed studies exploit the fruit fly (Drosophila) as a model system to provide insight into molecular mechanisms underpinning PCH1b.

PI_NAMEs: MORTON, DERRICK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Alleles;Amino Acid Substitution;Amino Acids;Atrophic;Attention;autosome;Behavior;behavioral phenotyping;Biochemical;Biological;Biological Models;Biology;Biophysics;Brain;brain morphology;Brain region;Breathing;Catalytic Domain;CCRL2 gene;Cell model;Cell Nucleus;Cells;Cerebellum;Child;Childhood;Clinical;Complex;CRISPR/Cas technology;Cytoplasm;Data;Defect;Development;Developmental Delay Disorders;Disease;dosage;Drosophila genus;Enhancers;Etiology;exosome;Fishes;fly;gene editing technology;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genotype;Goals;Heterogeneity;Homeostasis;Homologous Gene;Human;Impairment;In Situ;in vivo;in vivo Model;Individual;Inherited;insight;Life;life span;Link;Mass Spectrum Analysis;Methods;Microcephaly;Missense Mutation;Modeling;Molecular;Molecular Machines;Motor;motor behavior;motor learning;Movement;Muscular Atrophy;mutant;Mutation;Nervous System;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;novel;palliative;Pancreatic ribonuclease;Pathology;Phenotype;Play;Pontine structure;Pontocerebellar hypoplasia;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Reporting;Ribonucleases;RNA;RNA Decay;RNA Processing;Role;sensory system;Sequence Deletion;Series;Severities;single-cell RNA sequencing;Spinal Cord;System;Technology;Testing;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Investigating RNA dysregulation in Neurological Disease through study of Pontocerebellar Hypoplasia Type 1b


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Metabolic-dysfunction associated steatotic liver disease (MASLD) is a highly prevalent liver complication that disproportionately effects Hispanic/Latino patients. Lifestyle modifications focused on weight loss and management are recommended as the first-line treatment. This study will develop and test the feasibility of a culturally appropriate, multilevel lifestyle intervention to provide MASLD-specific education and support while also addressing the influences of family, healthcare providers and access to social services on lifestyle behaviors and weight management in Hispanic/Latino patients with MASLD.

PI_NAMEs: HEREDIA, NATALIA I (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Adult;Behavior;behavior change;Behavioral;Behavioral Sciences;Body Weight decreased;cancer transplantation;career;career development;Cirrhosis;Clinic;clinically significant;community clinical linkage;Complication;Data;design;Development;Development Plans;diabetes prevention program;Diet;Disease;disease diagnosis;Disease Management;Disparity;Dissemination and Implementation;Education;Effectiveness;Effectiveness of Interventions;effectiveness/implementation study;Ensure;Ethnic Population;Evaluation;Evidence based intervention;experience;Family;family influence;Family member;family support;Fatty Liver;feasibility testing;Food;food security;Goals;Health;Health Food;Health Personnel;Health Services Accessibility;health training;High Prevalence;Hispanic;Hispanic Populations;Hybrids;implementation evaluation;implementation research;Improve Access;improved;Individual;Intervention;intervention mapping;Interview;Knowledge;Latino;Latino Population;Life Style;Life Style Modification;lifestyle intervention;Lifestyle-related condition;Liver;Liver diseases;liver stiffness;liver transplantation;Maintenance;Malignant neoplasm of liver;Mentored Research Scientist Development Award;Mentors;Metabolic dysfunction;Methods;minority health;minority health disparity;Modeling;Monitor;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Needs Assessment;non-alcoholic fatty liver disease;Outcome;Patients;peer;Phase;Physical activity;Pilot Projects;pilot test;Prevalence;prevent;Primary Care Physician;primary outcome;Problem Solving;Process;Provider;Quasi-experiment;Questionnaires;racial population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Risk Factors;Role;satisfaction;secondary outcome;Services;skills;Social Environment;Social support;Social Work;Statistical Methods;Testing;theories;therapy development;tool;Training;Training Activity;voucher;Weight maintenance regimen;Work

PROJECT_TITLE: Developing and Testing a Multilevel, Culturally Appropriate Lifestyle Intervention For Hispanic Patients with Metabolic-dysfunction Associated Steatotic Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Addiction is a pressing health concern in the United States, and deaths from cocaine overdose have steadily increased over the past 5 years. Despite its increased prevalence, the intrinsic brain mechanisms that control response to cocaine are not clearly defined. Recent studies suggest that an endogenous signaling peptide in the brain, nociceptin, has potential to suppress addictive behaviors induced by cocaine. The proposed studies will fully explore the potential of nociceptin to block cocaine drug seeking behaviors, and will characterize the nociceptin circuits in the brain that may contribute to its suppressive actions. The findings may pave a path towards a novel therapeutic strategies to treat cocaine substance use disorders.

PI_NAMEs: MELIKIAN, HALEY E (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: addiction;Addictive Behavior;Behavior;Behavioral;behavioral study;Brain;Cell membrane;Cessation of life;Cocaine;Cocaine Dependence;cocaine overdose;cocaine reward;conditioned place preference;Coupled;Data;Dopamine;dopamine transporter;dopaminergic neuron;drug action;drug seeking behavior;extracellular;Female;Foundations;Future;Genetic;Glean;Health;Healthcare Systems;Infusion procedures;Link;male;Mediating;Microdialysis;Motivation;Mus;Neurons;Neuropeptides;nociceptin;Nociception;novel therapeutic intervention;Nucleus Accumbens;Opioid;optogenetics;overdose death;Peptide Signal Sequences;Persons;Pharmaceutical Preparations;presynaptic;Prevalence;psychostimulant;Public Health;receptor;response;Rewards;Signal Transduction;Source;stimulant abuse;Substance Use Disorder;System;Testing;tool;transmission process;United States;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Mesolimbic Nociceptin Signaling and Cocaine Reward Suppression

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Suckling and mastication behaviors are critical for the survival of all species. Unraveling the mechanism of activation and modulation of sensory-motor circuits during normal development is essential to elucidate muscle activity and how their dysfunction impacts neurodegenerative diseases. This proposal is designed to study the sensory-motor orofacial circuits in neonatal mice under normal conditions and in the neurodevelopmental motor neuron disease, spinal muscular atrophy.

PI_NAMEs: FLOREZ PAZ, DANNY MAURICIO (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Adult;Affect;Afferent Neurons;Age;age related;Amyotrophic Lateral Sclerosis;Animal Behavior;Animal Model;Behavior;Behavioral;Behavioral Assay;Brain Stem;Cause of Death;Cell Nucleus;Cells;Cerebral Palsy;Characteristics;Clinical;Dental Pulp;design;Development;Disease;Eating;Electrophysiology (science);experimental study;Facial Muscles;Feeding behaviors;Functional disorder;Genes;Genetic;Immunohistochemistry;Impairment;Infant Mortality;insight;Intake;Jaw;jaw movement;Knowledge;Mammals;Maps;Masseter Muscle;Mastication;Mechanical Stimulation;Mechanics;Methods;Midbrain structure;Motor;Motor Activity;Motor Neuron Disease;Motor Neurons;mouse model;Movement;Mus;Muscle;Muscle Contraction;Muscular Atrophy;neonatal mice;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neuromuscular Junction;neuron loss;neuronal cell body;neuronal circuitry;Neurons;Nutrient;Oral cavity;orofacial;Patients;Physiological;Population;postnatal;postnatal development;Pressoreceptors;Property;Proprioceptor;Proteins;pup;Role;Sensory;sensory mechanism;Sensory Receptors;SMN deficiency;SMN1 gene;Spinal Muscular Atrophy;suckling;Symptoms;Synapses;Time;Tracer;Transgenic Mice;Trigeminal Nuclei;Work

PROJECT_TITLE: Developmental mechanisms in the formation and function of sensory-motor circuits responsible for suckling and mastication.

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE It is well established that the hippocampus, entorhinal cortex, and prefrontal cortex as well as the coordination of activity across these brain regions is disrupted in any of the major neurological, neurodegenerative, and psychiatric diseases. Despite the knowledge that these circuits are particularly vulnerable in brain diseases, the diversity of memory computations that these brain regions support is only beginning to be revealed. By identifying how neural computations are performed and coordinated across brain regions, our results will be the foundation for therapies that profoundly improve cognitive function.

PI_NAMEs: LEUTGEB, STEFAN  (contact)

PROJECT_TERMS: Animals;Area;Award;Behavior;Brain;Brain Diseases;Brain region;cell cortex;Cells;Code;cognitive function;Data;Deterioration;Disease;Dorsal;entorhinal cortex;Event;follow-up;Foundations;Future;Hippocampus;improved;Interruption;Knowledge;Medial;Memory;Memory impairment;memory retention;Mental disorders;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurons;Pathology;Pattern;Population;Prefrontal Cortex;Role;Running;Short-Term Memory;Time;Variant;way finding;Work

PROJECT_TITLE: Memory computations across hippocampal, entorhinal, and prefrontal circuits


NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Huntington's disease (HD) is a devastating progressive adult-onset neurodegenerative disease. Currently, there is no treatment or a cure for HD. HD is one of the most common familial neurodegenerative disorders, with 30,000 clinically diagnosed HD patients and another 150,000-200,000 at risk for HD in the US.

PI_NAMEs: GRAY, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Adult;Affect;Astrocytes;autosome;Behavior;Behavioral;behavioral phenotyping;Brain;cell type;Cells;Clinical;clinical diagnosis;Cognitive;Corpus striatum structure;D Cells;Data;design;Development;Disease;Disease Progression;Dopamine D1 Receptor;Dopamine D2 Receptor;effective therapy;Electrophysiology (science);Experimental Designs;experimental study;extracellular;Feedback;Frequencies;Functional disorder;GABA Transporter 1;GAT3 transporter;Genetic study;Glial Fibrillary Acidic Protein;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Huntington Disease;Huntington gene;inhibitory neuron;Interneurons;Knowledge;Length;Modeling;Molecular;motor deficit;Movement;Mus;mutant;Mutate;Nerve Degeneration;nervous system development;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;neuroprotection;neurotransmission;optogenetics;overexpression;Parvalbumins;Pathway interactions;Patients;Phenotype;Play;Proteins;Risk;Role;Signal Transduction;Somatostatin;symptom treatment;Synapses;Thalamic structure;Toxic effect;uptake;Viral

PROJECT_TITLE: Exploring the contribution of astrocytes to Huntington disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE The proposed study will investigate the role of LZK and DLK, a pair of MAP kinase kinase kinases, in the multicellular responses to spinal cord injury, which will provide novel insight on the neuron intrinsic and extrinsic regulation of axonal repair after spinal cord injury. If manipulating LZK and/or DLK is found to enhance tissue and axonal repair after spinal cord injury, this would pave the way to develop therapeutic intervention targeting LZK and/or DLK. The ultimate goal is to improve the quality of life for people with spinal cord injury or related neurological conditions.

PI_NAMEs: ZHENG, BINHAI  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adopted;Animal Model;Area;Astrocytes;astrogliosis;Axon;axon growth;axon injury;axon regeneration;axonal degeneration;axonal sprouting;Brain Injuries;Caenorhabditis elegans;Cell Death;cell type;Central Nervous System;central nervous system injury;Cicatrix;Complex;Contusions;Corticospinal Tracts;Coupled;Data;Drosophila genus;Explosion;Fibroblasts;functional restoration;Future;gain of function;Gene Deletion;Genetic;genetic approach;Goals;Homologous Gene;IGF1 gene;improved;inhibitor;Injury;injury and repair;insight;Invertebrates;Knowledge;Leucine Zippers;Literature;loss of function;Macrophage;MAP Kinase Kinase Kinase;Mediating;Microglia;Modeling;Molecular;mouse genetics;Mus;Natural regeneration;Neurodegenerative Disorders;Neurologic;Neuronal Injury;Neurons;novel;Optic Nerve Injuries;osteopontin;Outcome;overexpression;Paralysed;Pathway interactions;Pericytes;Peripheral nerve injury;Persons;Phenotype;Phosphotransferases;Play;Positioning Attribute;preservation;Process;PTEN gene;Publications;Publishing;Quality of life;Recovery;Recovery of Function;regenerative;Regulation;repaired;Research;response;response to injury;RiboTag;Role;seal;Signal Pathway;Signal Transduction;Site;Spinal Cord;Spinal cord injury;spinal cord repair;STAT3 gene;Stroke;synergism;Testing;therapeutic development;Therapeutic Intervention;tissue repair;Tissues;transcriptomics;Viral

PROJECT_TITLE: The Role of a Pair of MAP3Ks in the Multicellular Response to Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative There is a large unmet need for developing new approaches to Treatment-Resistant Depression (TRD), a highly prevalent and debilitating disorder with major impact on public health. Clinical trials investigating deep brain stimulation (DBS), a neurosurgical approach widely used in neurological disorders, in the treatment of TRD have led to inconsistent results, possibly due to inadequate technology to precisely identify, target, and modulate the abnormal networks that mediate this disorder. The proposed studies will investigate the feasibility and safety of using a next-generation DBS system to “steer” stimulation simultaneously to two different brain regions implicated in TRD that may lead to new and better treatments for this and other severe neuropsychiatric disorders.

PI_NAMEs: GOODMAN, WAYNE K;POURATIAN, NADER ;SHETH, SAMEER ANIL (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Address;Affect;Algorithms;Amygdaloid structure;Assessment tool;Basic Science;Beds;Behavior;Behavioral;Bilateral;Biological Assay;Blinded;Boston;Brain;Brain region;capsule;Chronic;Classification;Clinical;Clinical Trials;cognitive control;Computer Models;computerized;Data;Data Set;Deep Brain Stimulation;depressive symptoms;Device or Instrument Development;Devices;Diffusion;dimension reduction;disability;Disease;Dose;Double-Blind Method;Ecological momentary assessment;efficacy evaluation;Electrodes;Electroencephalography;Engineering;Epilepsy;Europe;Excision;Face;Functional disorder;Goals;Health Care Costs;Implant;improved;Individual;innovation;Inpatients;insight;Investigation;Lead;Literature;Mediating;Mental Depression;Modeling;Monitor;Negative Valence;Nervous System Disorder;network models;Network-based;neural circuit;Neurocognitive;neuropsychiatric disorder;neuroregulation;neurosurgery;next generation;novel;novel strategies;novel therapeutics;open label;Outcome;Outpatients;Patients;Pattern;Physiological;Physiology;Placebo Effect;Positive Valence;Process;Public Health;Randomized;rational design;Regional Anatomy;Research;response;Safety;safety and feasibility;Severities;Site;Source;Spatial Distribution;Stream;success;Symptoms;System;Technology;Testing;therapeutic evaluation;therapy development;tractography;treatment-resistant depression;Validation;Ventral Striatum;Withdrawal;Work

PROJECT_TITLE: Deep Brain Stimulation for Depression Using Directional Current Steering and Individualized Network Targeting


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: This project is designed to identify the molecular and cellular changes that occur in sensory neurons after axonal injury and establish how these drive neuropathic pain and the evolution of peripheral neuropathy, exploring the extent to which these two syndromes are distinct or linked, and identifying opportunities for new therapeutic intervention.

PI_NAMEs: WOOLF, CLIFFORD J (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Afferent Neurons;Animals;Axon;axon injury;axonal degeneration;Behavioral;Cells;chemotherapeutic agent;Chemotherapy-induced peripheral neuropathy;Clinical;design;Development;Disease;Disease susceptibility;Evolution;Exposure to;Fiber;Genetic;Genetic Transcription;Goals;Image;Individual;Ion Channel;Link;Malignant Neoplasms;Molecular;Mutation;Neurons;Neuropathy;neurotoxic;new therapeutic target;novel therapeutic intervention;novel therapeutics;Pain;painful neuropathy;Pathology;Patients;Peripheral;Peripheral Nervous System Diseases;Phenotype;Population;Resolution;response;Risk Factors;Sensory;side effect;Sodium Channel;stem;Syndrome;Time;voltage

PROJECT_TITLE: Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE GBM is the most aggressive primary brain tumor with a two-year survival rate of less than 50% following surgical resection, radiation and chemotherapy. It is characterized by extensive hypoxia-induced, mitochondria-dependent phenotypic changes such as a glycolytic respiration, decreased ability to undergo apoptosis and extensive invasiveness which are linked to GBM's resistance to radiation and chemotherapy. Mitochondrial LonP1 is an ATP-stimulated protease, directly up-regulated by HIF-1α. LonP1 is overexpressed in human malignant gliomas and its elevated expression levels are associated with high glioma tumor grade and poor patient survival. Therefore, regulation of mitochondrial function by inhibiting LonP1 protease could represent a novel approach for GBM and potentially other fast-growing malignancies which heavily depend on hypoxic adaptation. The proposed project is based on our preliminary results obtained from in vitro (cell-based) studies with our LonP1 inhibitor compound BT317 and in vivo LonP1-overexpression xenograft models studies. BT317 is a small molecule compound and highly effective against multiple GBM cell lines – identifying BT317 as a potentially new therapy for this universally fatal disease.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);DAS, BHASKAR CHANDRA

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Animal Model;anti-cancer;Apoptosis;Automobile Driving;Binding;Biochemical;Bioenergetics;Biogenesis;Biological;Biology;blood-brain barrier crossing;Brain;Brain Neoplasms;Cell Culture Techniques;Cell Cycle;Cell Death Induction;Cell Line;Cell Survival;Cells;Cervical;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;clinical application;Clinical Trials;Colorectal;CRISPR/Cas technology;Cues;cytotoxic;Development;Disease;DNA biosynthesis;Drug Targeting;endopeptidase La;epithelial to mesenchymal transition;Equilibrium;Excision;FDA approved;gene therapy;Glioblastoma;Glioma;glioma cell line;Goals;Growth;Heat shock proteins;Homeostasis;Human;Hypoxia;Immunodeficient Mouse;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;inhibitor;interest;knock-down;Knock-out;Lead;Libraries;Link;Malignant Glioma;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Melanoma;Mesenchymal;Metabolic;meter;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Neoplasm Metastasis;Normal Cell;novel;novel strategies;novel therapeutics;nutrient deprivation;Operative Surgical Procedures;Oral;overexpression;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phenotype;Primary Brain Neoplasms;Process;Prognosis;Prognostic Factor;protein degradation;Proteins;Publishing;Radiation therapy;Recurrence;Recurrent tumor;Regulation;Resistance;Respiration;response;RNA;Role;Small Interfering RNA;small molecule;stable cell line;standard of care;stem cells;stem-like cell;Structure-Activity Relationship;Study models;Survival Rate;synergism;System;temozolomide;Testing;Therapeutic;therapy resistant;Toxic effect;tumor;tumor growth;tumor initiation;Up-Regulation;Xenograft Model

PROJECT_TITLE: Targeting of Mitochondrial Lon Protease as a Novel Therapy for Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Traumatic brain injuries (TBIs) affect 2.8 million individuals each year in the United States and often cause long-lasting cognitive and mood alterations, with the greatest external cause for TBI being falls, especially in older adults over 65 years of age. Given that behavioral tests performed to date after experimental brain trauma have primarily focused on motor and spatial learning deficits and not on commonly-reported complex attention impairments, this R01 application aims to characterize alterations in sustained attention, behavioral flexibility, and anxiety-like responses after experimental TBI in both young adult and aged rats, as well as to address mechanistic questions regarding altered cholinergic neurotransmission responsible for such behavioral impairments by restoring behavioral performance and acetylcholine brain marker levels with NS 1738 - a positive allosteric modulator of alpha-7-nicotinic acetylcholine receptors – alone or in a combination with enriched environment housing as a preclinical model of neurorehabilitation. Integrating animal models of higher-order cognitive processing in the behavioral battery after TBI is paramount to finding clinically-relevant therapeutic targets, and therefore the proposed studies will be carried out in males and females, an approach which may prove valuable for translation from bench to bedside and advanced rehabilitation research.

PI_NAMEs: BONDI, CORINA OANA (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Abbreviations;Acetylcholine;Acetylcholinesterase;Address;Affect;affective disturbance;age related;Age Years;aged;Aging;aging process;aging related;Agonist;alpha-bungarotoxin receptor;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Anti-Inflammatory Agents;Anxiety;arm;Attention;Behavior;behavior test;Behavioral;behavioral impairment;behavioral outcome;bench-to-bedside translation;Biological Markers;Brain;Brain region;Choline O-Acetyltransferase;cholinergic;Chronic;Clinic;clinically relevant;Cognition;Cognitive;cognitive process;Combined Modality Therapy;Complex;controlled cortical impact;Corpus striatum structure;Cytoskeleton;desensitization;design;Dimensions;Dorsal;environmental enrichment for laboratory animals;executive function;Exhibits;Exposure to;falls;Female;flexibility;frontotemporal degeneration;Functional disorder;Glial Fibrillary Acidic Protein;Goals;Growth;Hippocampus;Housing;human old age (65+);Impaired cognition;Impairment;Impulsivity;Individual;Injury;Ipsilateral;Laboratories;Learning;male;Mass Spectrum Analysis;Measures;Mediating;Memory;Menstrual cycle;Mental Depression;methyllycaconitine;Modeling;Motivation;Motor;neurobehavior;neurobehavioral;Neurobiology;neurogenesis;neurological rehabilitation;Neuron-Specific Enolase;Neurons;neuroprotection;neurotransmission;Neurotransmitters;Nicotinic Receptors;novel;older adult;Parietal;Pathway interactions;Performance;Pharmaceutical Preparations;Pharmacotherapy;Play;positive allosteric modulator;pre-clinical;Pre-Clinical Model;predictive marker;Predisposition;premature;Proteins;Proteomics;Psychopathology;Rattus;Reaction Time;receptor;Regulation;rehabilitation research;Rehabilitation therapy;Reporting;Research Personnel;response;Rewards;Risk;Role;self-reported anxiety;Serum;Short-Term Memory;Signal Transduction;Survivors;sustained attention;Synaptic plasticity;System;TBI treatment;Testing;Therapeutic;therapeutic target;Tissues;tool;Translating;transmission process;Traumatic Brain Injury;United States;Western Blotting;Woman;young adult

PROJECT_TITLE: Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: We are proposing a to study how mechanical stimuli can stimulate myelination and improve peripheral nerve regeneration after injury. If our working model is validated, this proposal will define the importance of mechanobiology in peripheral nerves and may reveal novel therapeutic targets for myelin diseases and for peripheral nerve regeneration.

PI_NAMEs: POITELON, YANNICK  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Affect;Agonist;Axon;axon injury;Cations;Cell Differentiation process;Cell Physiology;Cells;Chemicals;Clinical Treatment;Cytoskeleton;Data;design;Development;Disease;DNA-Binding Proteins;Economic Burden;Elasticity;Extracellular Matrix;Fiber;Funding;Gene Expression;Gene Expression Regulation;Genes;Genets;Growth;Health;Impairment;improved;In Vitro;in vivo;Injury;Ion Channel;knock-down;Knock-out;Knockout Mice;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Modeling;Molecular;mouse model;Myelin;myelination;nervous system development;Neuroglia;Neuropathy;new therapeutic target;novel;Pathway interactions;Peripheral nerve injury;peripheral nerve regeneration;peripheral nerve repair;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Physiologic pulse;Piezo 1 ion channel;Public Health;Radial;regeneration potential;Regulation;remyelination;Research;response;Role;Schwann Cells;sensor;Signal Transduction;small hairpin RNA;social;Stimulus;Structure;Symptoms;Testing;Therapeutic;Therapeutic Effect;Tissues;transcription factor;Transducers;Trauma;Ultrasonic wave;ultrasound;Variant

PROJECT_TITLE: Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Epilepsy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms linking demyelination to neuronal hyperexcitability and neurodegeneration will increase understanding of the pathogenesis of numer- ous neurological disorders and diseases including multiple sclerosis, trauma, and stroke. The project is relevant to NIH's mission, as the research pursues fundamental knowledge of glial-neuronal interactions in the brain, and how they go awry in the context of demyelinating disease, which may provide a foundation for the develop- ment of novel and more effective strategies to treat neurological disorders by selectively targeting specific glial- neuronal interaction mechanisms.

PI_NAMEs: BINDER, DEVIN K;TIWARI-WOODRUFF, SEEMA K (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Abate;Ablation;Acceleration;Anatomy;aquaporin 4;Area;Astrocytes;Autopsy;Brain;brain tissue;Cells;Cessation of life;Chronic;chronic demyelination;Clinical Research;cognitive function;Connexins;Coupled;Coupling;Cuprizone;Data;Demyelinating Diseases;Demyelinations;Development;Diet;disability;Disease;Dyes;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;Foundations;Functional disorder;Gap Junctions;Generations;Gliosis;Glutamates;Goals;Hippocampus;Human;Human Pathology;human tissue;Immunohistochemistry;Impairment;in vivo;insight;Interneurons;Knowledge;Lesion;Leukocytes;Link;Location;Mediator;Metabolic;Metabolism;Mission;Molecular;Monitor;Morbidity - disease rate;Morphology;mouse model;multi-electrode arrays;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Nerve Degeneration;Nervous System Disorder;neuronal excitability;Neurons;neurotransmission;novel;Onset of illness;Outcome;Parvalbumins;Pathogenesis;patient population;patient subsets;Patients;Population;Predisposition;Prevention;Process;protein expression;Proteins;Public Health;Publishing;reconstruction;Relapse;Reporter;Research;Rest;Role;Seizures;Signal Transduction;spatiotemporal;Specificity;Specimen;Stroke;Techniques;Testing;Time;Transgenic Organisms;translational impact;translational study;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: Demyelination is coupled to neuronal hyperexcitability leading to seizures


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Memory allows us to remember specific past experiences, but also find commonalities across experiences generalizable to novel situations. The proposed research will improve our understanding of mechanisms supporting memory specificity and generalization, their contribution to decision-making, and their implementation in the healthy brain. These findings will generate new predictions about the causes of a wide variety of memory impairments, such as reduced memory specificity in aging and Alzheimer’s disease, imbalance of specificity and generalization learning in anxiety, depression, and autism, and mixed patterns of impairments following a stroke.

PI_NAMEs: ZEITHAMOVA, DAGMAR  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Anterior;Anxiety;autism spectrum disorder;Basic Science;Behavior;Behavioral;Brain;Categories;Cognition;Cognitive;Corpus striatum structure;Data;Decision Making;Episodic memory;Equilibrium;Event;experience;Functional Magnetic Resonance Imaging;Hippocampus;Human;Impairment;improved;indexing;Individual;Individual Differences;information organization;Judgment;Knowledge;Learning;Link;Measures;member;Memory;Memory impairment;Mental Depression;Methods;Modeling;Nature;neural;neural patterning;Neurologic;neuromechanism;neuropsychiatric disorder;Neurosciences;novel;Participant;Pattern;Recording of previous events;Research;response;Role;Specificity;stem;Stroke;Structure;System;Testing;theories;tool;Work

PROJECT_TITLE: Neural mechanisms of specificity and generalization learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: There is a possible connection between insulin resistance, metabolic dysfunction-associated steatotic liver disease, and Alzheimer’s disease, but the biology behind this connection is presently unknown. The current proposal examines this connection by investigating the impact of age-associated changes in peripheral metabolism, mainly focusing on insulin resistance and inflammation in the liver, on neurodegeneration. Our findings will identify a novel function of liver macrophages and cytokines in bridging the connection between the aging liver and neurodegeneration, potentially identifying new therapeutic targets to treat metabolic liver disease, Alzheimer’s disease, and other age-related dementias.

PI_NAMEs: KIM, JASON K (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: adaptive immunity;Affect;age effect;age related;age related changes;age related neurodegeneration;Aging;aging brain;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;APP-PS1;Attenuated;Automobile Driving;behavioral study;Biological;Biology;Body System;Brain;brain metabolism;cell type;Cells;Cementation;Characteristics;cohort;Complex;cytokine;Data;Dementia;Dependovirus;Deposition;Diet;Encapsulated;Event;Fatty acid glycerol esters;Foundations;Fructose;Future;Gene Expression;Gliosis;Glucans;Glucose Clamp;glucose metabolism;Goals;Hand;Hepatocyte;Homeostasis;Hyperinsulinism;Immune;Immunity;Immunologics;immunoregulation;Impaired cognition;Impairment;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory modulation;Insulin Resistance;insulin signaling;Interferons;Interleukin-12;Interleukin-12 therapy;Kupffer Cells;Label;Learning;Link;Lipids;Liver;Liver diseases;liver function;liver metabolism;loss of function;Macrophage;Maps;Measurement;Measures;Mediating;Memory impairment;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Microglia;Modification;Molecular;Molecular Profiling;Mus;Myeloid Cells;Natural Immunity;Nature;Nerve Degeneration;neural circuit;new therapeutic target;novel;Obesity;Organ;particle;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;Play;Positioning Attribute;Process;Resolution;response;RNA;Role;Senile Plaques;Signal Transduction;Small Interfering RNA;Testing;Th1 Cells;therapeutic target;Tissues;tool;transcriptomics;Wild Type Mouse;Work

PROJECT_TITLE: Role of Peripheral Insulin Resistance and Inflammation in Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: "TDP-43 proteinopathy" refers to a relatively recently identified, common cause of cognitive impairment in aging (affecting approximately 50% of persons beyond age 85 years). It is increasingly clear that a variety of different factors in the aged brain can cause or exacerbate TDP-43 proteinopathy. We here propose a research program to characterize the disease-driving mechanisms of age-related TDP-43 proteinopathy and to use those data to help support future research efforts in the field.

PI_NAMEs: CYKOWSKI, MATTHEW DANIEL (contact);NELSON, PETER T.

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: ABCC9 gene;Address;Affect;Age;age related;age-related disease;Aging;aging brain;aging population;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amnestic Disorder;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Area;Arteriosclerosis;Automobile Driving;Autopsy;Biological Assay;biomarker development;Biometry;Blood Vessels;Brain;Brain Pathology;Brain region;Cells;Classification;Classification Scheme;Clinical;Clinics and Hospitals;cohort;Communities;comorbidity;Complex;Data;density;Detergents;Disease;disorder subtype;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Genetic;Genetic Polymorphism;genetic risk factor;genetic variant;Genomics;Goals;Hospitals;Human;Immunohistochemistry;Impaired cognition;improved;Individual;insight;Institution;Kentucky;Knowledge;limbic-predominant age-related TDP-43 encephalopathy;Location;Mass Spectrum Analysis;Methodist Church;Methods;misfolded protein;multidisciplinary;multimodal data;multimodality;Nerve Degeneration;neuropathology;novel;older adult;Pathologic;Pathology;Patients;Persons;Phase;Predisposition;Process;programs;protein TDP-43;Proteins;Proteome;Proteomics;Qualifying;Regional Anatomy;Research;Research Design;Resistance;Resources;Risk Factors;Sampling;Structure;synergism;tau Proteins;Testing;therapeutic development;Universities;vascular injury;Western Blotting;white matter;Work

PROJECT_TITLE: Age-related TDP-43 neuropathology: using disease-driving mechanisms to guide classification


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Lewy Body Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: A significant number of studies suggest that aggregated proteins in frontotemporal dementia (FTD) and Lewy body dementia (LBD), such as TDP-43 and α-synuclein, can spread from cell to cell, yet little is known about mechanisms of how the abnormal proteins spread. Our preliminary studies show that redox-based post- translational modifications (e.g., S-nitrosylation) of critical proteins contribute to aberrant aggregation and spread of TDP-43 and α-synuclein. In the proposed studies, we will determine if redox-dependent regulation of TDP-43 and p62 contributes to pathological spread of TDP-43 and α-synuclein in hiPSC (human induced pluripotent stem cell) and mouse transgenic models of FTD and LBD.

PI_NAMEs: NAKAMURA, TOMOHIRO  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;alpha synuclein;ALS patients;Alzheimer's Disease;Amyloid beta-Protein;Brain;C9ORF72;Cells;Cerebrum;Characteristics;comparison control;CRISPR/Cas technology;Dementia;Diagnostic;Disease;Disease Progression;Disulfide Linkage;Exocytosis;exposed human population;extracellular vesicles;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Generations;Genes;GTF2H1 gene;Human;human induced pluripotent stem cells;in vivo;Induced pluripotent stem cell derived human neuron;Injury;Journals;Knockout Mice;Lewy Body Dementia;Link;Mediating;misfolded protein;Modeling;Monitor;mouse model;mutant;Mutation;Nature;Nervous System;Neurodegenerative Disorders;neuron loss;Neurons;neurotoxicity;Nitric Oxide;Nitrogen;Organoids;oxidation;Oxidation-Reduction;Oxygen;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Post-Translational Protein Processing;Process;protein aggregation;Protein S;protein TDP-43;Proteins;Publishing;Regulation;RNA Binding;Science;SKIL gene;stem cell model;Synapses;synucleinopathy;tau aggregation;TDP-43 aggregation;Techniques;therapeutically effective;Tissues;Transgenic Mice;Transgenic Model;transmission process

PROJECT_TITLE: S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Alzheimer’s disease (AD) affects over 5.7 million Americans and is expected to rise to nearly 14 million people by 2060, as the number of people living with this disease doubles every 5 years. Cognitive and memory impairments are a defining characteristic of AD and are thought to arise from dysfunctional circuits spanning multiple brain areas. Our proposed studies will advance foundational knowledge of cognition- and memory- related brain circuits across AD clinical stages and their links to neuropathology, and more generally, also contribute novel tools for examining dynamical causal circuits underlying human brain function and dysfunction.

PI_NAMEs: MENON, VINOD  (contact)

PROJECT_TERMS: Address;Affect;Algorithmic Software;Alzheimer's Disease;American;Amyloid beta-Protein;Area;Bayesian Analysis;Bayesian Modeling;behavioral impairment;beta amyloid pathology;Brain;Brain region;brain research;Characteristics;Clinical;Cognition;Cognitive;Communities;Computer Models;computerized tools;connectome;Data;Development;disability;Disease;dynamic system;Episodic memory;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Goals;Human;human disease;Impaired cognition;in vivo;innovation;Knowledge;Link;medial temporal lobe;Memory;Memory impairment;Methods;Mission;Monte Carlo Method;mortality risk;Nerve Degeneration;neuropathology;Neurosciences;novel;optogenetics;Pathology;Pattern;Persons;Phenotype;Positron-Emission Tomography;Productivity;Progressive Disease;Reproducibility;Research;Resource Sharing;Rodent;Sampling;Short-Term Memory;Signal Induction;Signal Transduction;Software Tools;System;tau Proteins;Techniques;temporal measurement;tool;United States National Institutes of Health;Validation;Wisconsin

PROJECT_TITLE: Computational modeling of dynamic causal brain circuits underlying cognitive dysfunction in Alzheimer's disease


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: The proposed research is relevant to public health because the proposed research aims to develop new, non- addictive, and safe small molecule to treat neuropathic pain. Thus, the proposed research is relevant to the mission of NINDS, as successful small molecule development will reduce the burden of peripheral neuropathy.

PI_NAMEs: ABELL, ANDREW ;GRACE, PETER M (contact)

PROGRAM_OFFICER_NAME: RICE, MATTHEW WARNER

PROJECT_TERMS: Adverse effects;Adverse event;Analgesics;Anti-Inflammatory Agents;Antioxidants;Behavior;Benchmarking;Benign;Binding Proteins;Biochemical;Biochemical Pathway;Biological;Biological Assay;Canis familiaris;Cardiovascular system;Central Nervous System;chemical reaction;chemical stability;Chemicals;chronic pain;chronic pain management;Data;design;Development;Diabetic Neuropathies;Dose;drug development;Drug Kinetics;drug reinforcement;FDA approved;Fumarates;G-Protein-Coupled Receptors;gastrointestinal;Heart;Hydrogen Peroxide;imaging biomarker;Immune;Immunosuppression;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;Inflammation Mediators;innovation;Ion Channel;iterative design;Kidney;Lead;lead optimization;Libraries;manufacture;Maximum Tolerated Dose;Mediating;Mediator;Medicine;Metabolic;Metabolic Pathway;Mission;Modeling;multiple sclerosis treatment;National Institute of Neurological Disorders and Stroke;Nitrogen;non-opioid analgesic;nuclear factor-erythroid 2;Oxygen;Pain;pain behavior;pain model;painful neuropathy;Pathology;Pathway interactions;Peripheral Nervous System Diseases;Peroxonitrite;Pharmaceutical Preparations;Pharmacology Study;Pharmacotherapy;Phase;Phase I Clinical Trials;Plasma;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Preclinical Drug Development;Prodrugs;Program Development;programs;Property;Protein Isoforms;Public Health;Rattus;Reaction;Reflex action;Reporter;Research;Research Project Grants;Resources;respiratory;Risk;risk/benefit ratio;Rodent;Rodent Model;Route;Safety;scale up;Series;side effect;Site;small molecule;standard of care;Structure-Activity Relationship;System;targeted biomarker;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Index;therapeutic target;Time;Tissues;Toxic effect;treatment response;trial planning;Type 2 diabetic

PROJECT_TITLE: Development of Pathology-activated Drugs for Treatment of Neuropathic Pain


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Women's Health Research

PHR: This K01 application proposes a research plan that incorporates hormonal biomarkers as a novel risk stratification tool to identify high risk groups of female concussion patients, who may be most vulnerable to mTBI-induced sexual dysfunctions.

PI_NAMEs: ANTO-OCRAH, MARTINA  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accident and Emergency department;Acute;Affect;affective disturbance;Age;Arousal;Biological;Biological Markers;birth control;Brain Concussion;Brain Injuries;bridge program;career;career development;Caring;Categories;Clinical;clinical care;cohort;concussive symptom;design;Development Plans;digital;Disease;Disparity;Drops;Eligibility Determination;Emergency department visit;Emotional;Epidemiologist;Epidemiology;experience;Female;follow-up;functional decline;Goals;Health;high risk;high risk population;Hormonal;Human;Hypothalamic structure;improved;injured;Injury;interest;limb injury;Measures;men;Menstrual cycle;Mental Health;Mentors;mild traumatic brain injury;Minority;Morbidity - disease rate;National Institute of Neurological Disorders and Stroke;Neurology;neuroprotection;novel;Outcome;Participant;Pathology;Patient Self-Report;patient subsets;Patients;Phase;physical conditioning;Physiological;Pituitary Gland;Post-Concussion Syndrome;Predisposition;Premenopause;Progesterone;Progestins;proliferative phase Menstrual cycle;Prospective cohort;psychologic;Public Health;Quality of life;Questionnaires;Recovery;recruit;Reporting;reproductive;reproductive epidemiology;Reproductive Health;Research;Research Project Grants;Research Proposals;response;Risk;risk prediction;risk stratification;satisfaction;Serum;sex;Sex Behavior;Sex Differences;Sex Functioning;Sexual Arousal;Sexual Dysfunction;sexual encounter;Sexuality;skills;Source;steroid hormone;Subgroup;Surveys;Symptoms;Testing;Time;tool;Training;trauma centers;Withdrawal;Woman;Women's Group;Women's Health;women's morbidity;Work;World Health Organization

PROJECT_TITLE: K01 Menstrual Phase, Sexual Dysfunction, mTBI


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Neurosciences;Opioids;Pain Research

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: This new R61/R33 application seeks to address the unmet need for reliable, efficient, and objective preclinical procedures to improve translational predictive validity in analgesic drug discovery. The crisis of opioid abuse and overdose deaths has stimulated the effort to develop non-opioid, non-addicting analgesics, and this effort depends in part on preclinical procedures for analgesic efficacy testing with high predictive validity in general and resistance to false-positive effects in particular. Here we propose a new procedure with excellent potential to have high sensitivity to analgesics, selectivity for analgesics vs. non-analgesics, and additional attributes to promote replicability of results, efficiency in experimental design, and objective and quantitative data collection.

PI_NAMEs: NEGUS, SIDNEY S (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Abdomen;Absence of pain sensation;Acute;Acute Pain;Address;Affect;Analgesics;Animals;Behavior;Behavioral;Biological Assay;Characteristics;chronic pain;Clinical;clinical effect;clinically relevant;cohort;Collaborations;Complex;Cutaneous;Data;Data Collection;Depressed mood;Development;Diagnosis;Diazepam;Disease;disease model;Dose;drug development;drug discovery;efficacy testing;Environment;Evaluation;Experimental Designs;Face;feeding;Female;Floor;Foundations;Freund's Adjuvant;Functional impairment;Funding;General anesthetic drugs;Genes;Goals;Helping to End Addiction Long-term;Human;improved;Inbred ICR Mice;Inbred Strain;inflammatory pain;Institution;Intestines;Intraperitoneal Injections;Ketoprofen;Lactic acid;Laparotomy;Lithium Chloride;Local Anesthetics;Locomotion;male;Measures;mechanical stimulus;Mental Depression;Modeling;Monitor;Mononeuropathies;Morphine;Motor Activity;motor impairment;Movement;mu opioid receptors;Mus;nerve injury;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;opioid abuse;Opioid agonist;opioid epidemic;opioid mortality;Pain;Pain management;Pain Measurement;pain model;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;Procedures;Reflex action;Resistance;response;restoration;scale up;sedative;Series;sex as a biological variable;Sickle Cell Anemia;spared nerve;Stimulus;Sum;Surgical incisions;therapeutic candidate;Translations;United States National Institutes of Health;Universities;Validation;Visceral;Visceral pain;Withdrawal

PROJECT_TITLE: A Novel Assay to Improve Translation in Analgesic Drug Development

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative: Polysomnographic Biomarkers of Brain Aging RELEVANCE: Loss of brain function including memory and executive function is an inevitable part of aging, yet some individuals’ brains age better than others. We recently developed the brain age index – a statistical model that reports the difference between an individual’s apparent brain age, based on the pattern of overnight EEG (brain waves), and their chronologic age. This project will use existing data from 4 large cohorts to further develop and validate sleep EEG-based biomarkers of brain health, by characterizing the relationships of brain waves during sleep to cognitive health and to the structural health of the brain.

PI_NAMEs: WESTOVER, MICHAEL BRANDON (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: 20 year old;Address;Age;age related changes;Aging;aging brain;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Archives;Arousal;basal forebrain;biological age;Biological Markers;Biological Process;Brain;Brain Diseases;brain health;brain magnetic resonance imaging;Brain Pathology;Cerebrum;Chronic;Chronology;Claustral structure;Clinical;Clinical Trials;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;Complex;Data;deep neural network;Dementia;Devices;Diabetes Mellitus;Disease;Drainage procedure;Early Diagnosis;Electroencephalography;Epidemiology;epidemiology study;executive function;Exhibits;Framingham Heart Study;functional loss;General Hospitals;Genome;glymphatic system;Goals;Health;healthy aging;Heart;high risk population;Hippocampus;HIV;HIV Infections;Home;Hypertension;Impaired cognition;indexing;Individual;individual patient;Intervention;Israel;Knowledge;Koreans;large datasets;Learning;Life Expectancy;Link;Lung;Machine Learning;machine learning algorithm;machine learning prediction;Magnetic Resonance Imaging;Massachusetts;Measurable;Measures;Medial;Medical center;Memory;memory consolidation;mild cognitive impairment;model development;Modeling;mortality;Motivation;multi-task learning;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurologic;neuropathology;Neuropsychological Tests;Neuropsychology;non rapid eye movement;novel;novel therapeutics;Outcome;Pathology;Patient Care;Patients;Pattern;Physiological;Play;Polysomnography;Population;Positron-Emission Tomography;Prefrontal Cortex;Process;Property;Qualifying;REM Sleep;Reporting;Research;Risk;Role;Science;Series;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleep Fragmentations;sleep physiology;sleep spindle;Sleep Stages;Smoker;specific biomarkers;Statistical Models;System;Test Result;Testing;therapy development;Thick;Thinness;Time;Variant;Work

PROJECT_TITLE: Establishing a Brain Health Index

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Patient Safety;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Modified Public Health Relevance Section Suicide has been a leading cause of death and disease burden for the past 50 years, and existing treatments  fall woefully short of meeting this immense need because they are not scalable. People who perceive suicide  as relatively less negative/aversive are more likely to attempt suicide. This K23 proposal aims to test whether a  highly scalable, smartphone-delivered treatment adapted for adults with relatively frequent and recent suicidal  thoughts/behavior (STB) is safe, acceptable and can increase suicide-aversion (i.e., make suicide seem  worse) and thereby reduce STB severity and incidence.

PI_NAMEs: JAROSZEWSKI, ADAM  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adult;Affect;affection;Agitation;American;Anxiety;Area;arm;Association Learning;Behavior;Behavior Therapy;Behavioral;Behavioral Assay;behavioral outcome;Boston;burden of illness;career;career development;Caring;Cause of Death;Cellular Phone;Cessation of life;conditioning;cost effective;Data;Data Reporting;design;digital mental health;digital treatment;Disabling;dosage;Ecological momentary assessment;Emergency Situation;Ethics;evidence base;experience;falls;Family;Feeling suicidal;follow-up;Future;Goals;Growth;healthcare burden;Healthcare Systems;high risk;human subject protection;Imagery;Incidence;Informed Consent;inpatient service;Intervention;Interview;Investigational Therapies;Learning;Life;Measures;Mediating;Mediation;Medical;meetings;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;mHealth;Modification;Moods;National Institute of Mental Health;non-suicidal self injury;Participant;participant enrollment;Patient Recruitments;Patient Self-Report;Persons;phase III trial;prevent;primary outcome;Procedures;Process;prospective;public health relevance;Randomized;Randomized, Controlled Trials;reducing suicide;Reporting;Reproducibility;Research;Risk Factors;Risk Management;Safety;safety assessment;safety study;Sampling;Scientific Advances and Accomplishments;secondary outcome;Severities;skills;statistics;Stimulus;Stress;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Symptoms;temporal measurement;Testing;Therapeutic;therapeutic evaluation;Training;treatment duration;treatment response;treatment trial;usability;user centered design;Validation;Work

PROJECT_TITLE: A Randomized Controlled Trial of A Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Boston

ORG_DEPT: CHEMISTRY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: The Kritzer lab addresses foundational problems in drug discovery. In this MIRA project, we describe new innovations including novel compounds that block key proteins implicated in late-stage cancers, novel classes of compounds that can degrade any cellular protein on demand, and novel methods to understand how large- molecule therapeutics enter cells and how to design them to enter cells more efficiently.

PI_NAMEs: KRITZER, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Adopted;Algorithm Design;Area;Autophagocytosis;Binding;Biological Assay;cell type;Cells;Cellular biology;chemotherapy;Chimera organism;CRISPR screen;Cytosol;Data;Degradation Pathway;design;Disease;DNA Damage;drug development;drug discovery;Endosomes;Genetic;Human;inhibition of autophagy;inhibitor;innovation;Kinetics;Learning;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Molecular Evolution;novel;Penetration;Protac;protein degradation;Protein Family;protein protein interaction;Proteins;research and development;screening;Series;small molecule inhibitor;stapled peptide;Structure;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Developing Autophagy-Targeting Chimeras and Optimizing Cell Penetration of Large-Molecule Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because it is focused on studying a critical step in the development of Alzheimer’s disease (AD), microglia activation, which contributes to inflammation and disease progression. The proposal is designed to examine the contributions of circulating cell-free DNA on microglial activation and chronic inflammation. The proposed research lays the groundwork for clinical studies to identify individuals with AD and chronic inflammation who can benefit from treatments targeting microglia activation pathways.

PI_NAMEs: NIDADAVOLU, LOLITA S (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Adult;Aftercare;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease risk;American;Autopsy;Biological Assay;Biology;Biometry;Blood specimen;Brain;brain cell;career;Cell Death;Cell Death Process;cell free DNA;Cell Line;Cells;Central Nervous System;Chronic;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;Collaborations;Communicable Diseases;cytokine;Data;Data Set;design;Development;Disease;Disease associated microglia;Disease Progression;DNA;DNA purification;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;experience;Exposure to;Functional disorder;Gene Expression Profiling;Genes;Geriatrics;Gerontology;glial activation;Goals;high risk;Human;Immune;Immune response;Immune signaling;In Vitro;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;inhibitor;innate immune pathways;Innate Immune Response;Innate Immune System;Interleukin-6;K-Series Research Career Programs;Knowledge;Link;lipid metabolism;Measures;medical schools;Medicine;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Microglia;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuron loss;neurotoxicity;new therapeutic target;NF-kappa B;novel;Outcome;Participant;Pathway interactions;Patient Recruitments;Patients;Phagocytosis;precision medicine;Production;professor;Public Health;religious order study;Research;Research Personnel;response;Sampling;Scientist;sensor;Serum;skills;small molecule;Source;Stains;Testing;TNF gene;Training;Transcript;transcriptome sequencing;transcriptomics;Universities;Western Blotting

PROJECT_TITLE: Microglial Responses to Cell-free DNA in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE: In the fight against Alzheimer’s disease, functional magnetic resonance imaging (fMRI) holds promise as a non-invasive, widely available, relatively inexpensive source of biomarkers that could help advance clinical trials and clinical care. A barrier to fMRI-based biomarkers is the challenge of individual precision, given the high noise levels of fMRI data. This project will produce novel statistical techniques for fMRI analysis capable of extracting accurate, nuanced functional brain features in individuals and will deploy those techniques to develop fMRI-based biomarkers of Alzheimer’s disease.

PI_NAMEs: MEJIA, AMANDA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Adoption;Affect;aging population;Alzheimer's Disease;Alzheimer’s disease biomarker;American;Anatomy;Bayesian Modeling;Benchmarking;Biological Markers;biomarker discovery;Blood;blood-based biomarker;Brain;Brain Mapping;Caring;Cerebrospinal Fluid;Clinical;clinical care;clinical trial participant;Clinical Trials;Cognitive;cognitive process;Complement;Complex Mixtures;Computer software;Data;Data Analyses;data format;Data Set;Development;Diagnosis;Disease;Eligibility Determination;Ensure;Family;fighting;Functional Magnetic Resonance Imaging;Future;Goals;Hour;Image;image processing;improved;Incidence;independent component analysis;Individual;interest;Joints;Lead;machine learning model;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Methods;mild cognitive impairment;Mind;Modeling;multimodality;neuroimaging;new technology;Noise;novel;novel marker;Participant;Patients;Population;Population Heterogeneity;Positron-Emission Tomography;Procedures;Property;Protocols documentation;repository;Research;Risk;Scanning;screening;Sensitivity and Specificity;Series;simulation;Site;Source;Spinal Puncture;Standardization;Statistical Methods;success;Techniques;Technology;Therapeutic Clinical Trial;Time;tool;user friendly software;validation studies;Work

PROJECT_TITLE: Individual functional brain mapping for biomarker discovery in Alzheimer's

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Chronic Pain;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Neurosciences;Pain Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Inflammatory bowel diseases (IBD) are a group of chronic inflammatory illnesses of the gastrointestinal tract that represents a significant public health and economic burden. There is an urgent need to improve our understanding of modulators of intestinal inflammation in order to identify novel therapeutic targets. Based on my recent findings that TRPV1+ nociceptors modulate the intestinal microbiota and mitigate intestinal inflammation during acute intestinal damage and inflammation, the focus of this proposal is to elucidate the role of these neuro-immune interactions and neuron-microbiota axis in regulating intestinal inflammation and tissue protection in the context of IBD.

PI_NAMEs: ZHANG, WEN  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Abdominal Pain;Acute;adaptive immunity;Address;Affect;Afferent Neurons;American;antagonist;Area;Automobile Driving;Biological;Biopsy;Calcitonin Gene-Related Peptide;career;career development;Cell Culture System;Central Nervous System;Characteristics;Chronic;chronic infection;chronic inflammatory disease;Clinical;Coculture Techniques;Collaborations;Colorectal Cancer;common symptom;Communication;comorbidity;Coupled;Cre lox recombination system;Crohn's disease;cytokine;Data;density;designer receptors exclusively activated by designer drugs;Development;Development Plans;Diarrhea;Digestive System Disorders;Disease;Drug Targeting;Economic Burden;Educational process of instructing;Enrollment;enteric infection;Environment;Enzyme-Linked Immunosorbent Assay;Equipment;experimental study;Exposure to;Fluorescence Microscopy;Fostering;Gastroenterology;gastrointestinal infection;Gastrointestinal tract structure;Genes;Genetic;genetic manipulation;Goals;gut inflammation;gut microbiota;Hemorrhage;high risk;high standard;host-microbe interactions;Human;Immune Targeting;Immunofluorescence Microscopy;Immunologics;Immunology;immunoregulation;Impaired wound healing;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injections;innovation;Institution;interdisciplinary approach;intestinal injury;Intestines;Laboratories;Light;loss of function;Mediating;Medicine;Mentors;Mentorship;microbial;Microbiology;microbiota;Modeling;Molecular;mouse model;Mus;nerve supply;Neurobiology;Neurogenic Inflammation;Neuroimmune;Neuroimmunomodulation;Neurons;Neuropeptides;neutralizing antibody;new therapeutic target;Nociception;Nociceptors;novel;Organ;Pain;Pathologic;Pathway interactions;Patients;Pattern;peptide P;Phase;Physiological;Population;Process;protective effect;Public Health;Publishing;Quality of life;Regulation;Research;Research Personnel;Research Project Summaries;Resources;Role;Sensory;Severity of illness;Signal Transduction;single-cell RNA sequencing;skills;Specialist;Stimulus;Substance P;success;Symptoms;T cell response;T-Lymphocyte;teacher;Techniques;Testing;Therapeutic;Tissues;transcriptome sequencing;transmission process;TRPV1 gene;Ulcerative Colitis;Virus;Writing

PROJECT_TITLE: Nociceptor regulation of intestinal inflammation and tissue protection

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE Experience-dependent refinement and efficient memory storage in CNS circuits is thought to require homeostatic forms of plasticity, such as synaptic scaling and intrinsic plasticity, that stabilize overall neuronal activity by endowing individual neurons with a `firing rate set point'. Here we will investigate the mechanisms and function of these set points, and ask how their loss impacts critical features of circuit function including memory stability. These studies will enhance our understanding of neurological disorders that arise from aberrant circuit excitability, and will provide a new avenue of investigation into disorders (such as PTSD) that arise from excessive generalization during aversive learning.

PI_NAMEs: TURRIGIANO, GINA G (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Animals;autism spectrum disorder;Back;Central Nervous System;Development;Disease;Endowment;Epilepsy;experience;Feedback;Goals;hippocampal pyramidal neuron;Homeostasis;in vivo;Individual;Investigation;Learning;Memory;memory encoding;Molecular;Nature;neocortical;Nervous System Disorder;Neurons;Post-Traumatic Stress Disorders;prevent;Process;programs;Property;Research Support;Role;Sensory;Synapses;Testing;tool;Work

PROJECT_TITLE: Mechanisms and function of firing rate homeostasis in cortical circuits