NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative: Aneuploidy has been associated with a worse clinical outcome in many solid tumors, and specific chromosomal aberrations can be prognostic. Yet, little attention has been given to the role of aneuploidy in MPSNT. Our prior work has shown that Chr8 gain is a near universal event in MPNST and that the Chr8 gene, UBR5 is highly expressed in MPNST compared to the benign precursor, and promotes cell survival in. The goal of this proposal is to define when in malignant transformation Chr8 gain and UBR5 expression occurs, to determine if there is a correlation with overall survival, and to dissect the mechanism by which UBR5 functions in MPNST. These studies have the potential to impact early diagnosis, prognostication, and development of therapies for MPNST through a better understanding of the pathogenesis of this deadly cancer.

PI_NAMEs: HIRBE, ANGELA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;Aneuploidy;Apoptotic;Attention;Benign;Biological;Biological Assay;cancer predisposition;cancer recurrence;cancer therapy;cell growth;Cell Proliferation;Cell Survival;Cells;Chromosome 8;chromosome 8 gain;Chromosome abnormality;Chromosome Arm;Clinical;Collection;combination cancer therapy;Coupling;Data;Development;Diagnosis;DNA Sequence Alteration;Early Diagnosis;effective therapy;Event;Exhibits;experimental study;Fluorescent in Situ Hybridization;Genes;Genetic;genome sequencing;Genomics;Glioma;Goals;Growth;Heterogeneity;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;Individual;Injections;knock-down;Lesion;Malignant - descriptor;Malignant Neoplasms;Mediating;migration;Modality;Modeling;Molecular;Mus;mutant;Neoplasms;Neoplastic Schwann Cell;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;neurogenetics;NF1 gene;novel;novel therapeutic intervention;Oncogenic;Outcome;Outcome Study;Pathogenesis;Pathway Analysis;Pathway interactions;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;Plexiform Neurofibroma;prognostic;prognostication;Proliferating;Recurrent tumor;Regulation;Risk Assessment;Role;Sarcoma;sciatic nerve;Series;small hairpin RNA;Solid Neoplasm;Syndrome;System;Testing;Therapeutic;therapeutic target;therapy development;tool;transcriptome sequencing;tumor;Tumor Biology;Tumor Cell Line;tumor progression;tumorigenesis;ubiquitin-protein ligase;Up-Regulation;whole genome;Work

PROJECT_TITLE: Regulation of MPNST pathogenesis by Chromosome 8 gene, UBR5

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Current hepatitis C virus diagnostics present the greatest barrier to viral cure and elimination, and an accurate, simple, rapid, and affordable molecular test for viral RNA is needed to increase detection of hepatitis C virus along with important coinfections such as human immunodeficiency virus. This proposal seeks to eliminate key barriers to low-cost molecular testing for RNA viruses using novel chemistries and bespoke microfluidics that enable minimally trained healthcare workers to perform on-demand duplex molecular testing in the clinic. Achieving device development proposed in Aim 1 or Aim 2 will represent a significant advance that can be leveraged to improve hepatitis C testing, and combined, these technologies will have an important positive impact on RNA virus detection with an economical, agile molecular detection system.

PI_NAMEs: MYERS, DAVID RICHARD;WAGGONER, JESSE  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: 3D Print;Anti-viral Therapy;Binding Proteins;Blood capillaries;Blood specimen;Buffers;Caring;Chemicals;Chemistry;Clinic;co-infection;Collection;cost;Cryopreservation;Data;design;Detection;detection platform;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Economic Development;economic impact;Equipment;fighting;follow-up;global health;Goals;HCV screening;Health Personnel;health training;Heating;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Therapy;Hepatitis C virus;HIV;implementation cost;improved;Individual;Infection;infection rate;innovation;interest;Liquid substance;Marketing;Methods;Microfluidics;Molecular;Mutate;novel;Paper;Patients;Persons;Pharmaceutical Preparations;Plasma;Prospective Studies;Protocols documentation;Reagent;Research;research clinical testing;response;RNA;RNA Viruses;Robotics;Sampling;Site;standard of care;System;Technology;Temperature;Testing;transcription mediated amplification;United States;United States National Institutes of Health;Universities;usability;Viral;viral detection;viral RNA;virus testing;Visit;Whole Blood;World Health Organization

PROJECT_TITLE: Integrating low-cost and versatile technologies to achieve colorimetric HCV and HIV detection from whole blood

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Digestive Diseases;Genetics;Microbiome;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Fecal microbiota transplant (FMT) is a promising, novel intervention to promote restitution and repair of colonic dysbiosis, but does it adequately restore eubiosis of the small intestine which differs considerably in membership, function, and impact on the host? We will test the hypothesis that region-specific donor microbes transplanted into non-native intestinal niches inadequately restore microbiota composition and function, resulting in adverse effects on host health, metabolism and immunity. The insights gained from these studies are likely to raise awareness to the potential limitations and unintended consequences of current FMT practices and lead to a rethinking of strategies for the development of future live biotherapeutic products (LBPs) for maintenance of health and better clinical outcomes for many diseases that have a microbial basis.

PI_NAMEs: CHANG, EUGENE B (contact);MARTINEZ-GURYN, KRISTINA BROOKE

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adverse effects;adverse outcome;Affect;Antibiotic Therapy;Antibiotics;Attention;Awareness;Biochemical Pathway;Bioinformatics;Biological Response Modifier Therapy;Brain;Budgets;CD4 Positive T Lymphocytes;Circadian gene expression;Circadian Rhythms;Clinical;clinical practice;Clostridium difficile;Collaborations;Colon;colon microbiota;Communities;cost;Crohn's disease;Data;Development;Diet;Disease;dysbiosis;Ecosystem;energy balance;Energy Metabolism;Engraftment;Environment;Equilibrium;Experimental Models;fecal transplantation;Flow Cytometry;Formulation;Fostering;Future;gastrointestinal;Gene Expression;gene function;Gene Targeting;Genetic Transcription;germ free condition;Germ-Free;gut microbes;gut microbiota;Health;Hepatic;human subject;Immune;immune function;Immunity;Immunologic Tests;In Vitro;in vivo;Infection;insight;interest;Intervention;Intestines;Laboratories;Large Intestine;Life Style;Light;Liver;Maintenance;Measurement;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Metagenomics;Microbe;microbial;microbial host;microbiome;microbiota;microbiota composition;microbiota transplantation;Modeling;Motor Activity;mouse model;Mus;Natural Remedy;Nature;non-Native;novel;Organoids;Outcome;Outcome Assessment;Patients;Physiology;Play;post-transplant;Preparation;Probiotics;programs;Regimen;repaired;Ribosomal RNA;Role;Saline;Shotgun Sequencing;Shotguns;Small Intestines;stem;Systemic disease;Testing;Thinking;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Transplantation

PROJECT_TITLE: Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeutics

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE We will perform an epidemiological examination of the etiology of Autism Spectrum Disorder (ASD) in children born preterm (before 37 weeks of gestation), and term, using Swedish and Finnish national registers and a California replication sample. We will also examine genetic risk markers in a large US genetic database - SPARK, and in a NIH funded genetic sample from Sweden. The aim is to close knowledge gaps in children born preterm and in ASD etiology.

PI_NAMEs: SANDIN, SVEN  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 37 weeks gestation;Address;Affect;Apgar Score;autism spectrum disorder;autistic children;Biometry;Birth;California;carrier status;Child;clinical diagnosis;clinical practice;cohort;comorbidity;Country;Data;data registry;Data Sources;Databases;Development;Diagnosis;Disease;disorder risk;Education;Environmental Risk Factor;epidemiologic data;Epidemiology;Etiology;Europe;Family;Fetus;Finland;Funding;General Population;Genetic;genetic architecture;genetic association;Genetic Databases;Genetic Markers;Genetic Risk;genomic biomarker;Genomics;Gestational Age;Goals;Health;Heritability;Individual;individuals with autism spectrum disorder;Induced Labor;Influentials;Intervention;Knowledge;Life;Link;male;Measures;Mediating;Mediation;Medical;model of autism spectrum disorder;modifiable risk;Modification;Molecular Genetics;Neurodevelopmental Disorder;novel;Paternal Age;Pathway interactions;Play;polygenic risk score;Population;Population Attributable Risks;population based;Predisposition;Pregnancy;Pregnant Women;Premature Birth;Premature Rupture Fetal Membranes;Process;prospective;Prospective cohort;Public Health;public health intervention;rare variant;Recurrence;Research;Risk;Risk Estimate;Risk Factors;Risk Marker;Role;Sampling;sex;Single Nucleotide Polymorphism;Socioeconomic Status;Source;Subgroup;Sweden;Term Birth;Testing;Time trend;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Autism in Preterm Birth

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Immunization

ORG_CITY: KALAMAZOO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

ORG_STATE: MI

PHR: Project Narrative As the population of aged individuals rises so will the burden of aging -associated diseases that are counteracted by natural antibodies produced by a unique population of B lymphocytes termed B1 cells. B1 cells and the natural antibody protection they afford deteriorate with advancing age in males, but remain highly effective in females, although the reasons for this sex-associated disparity remain unclear. The present study is designed to fill this gap in knowledge by utilizing advanced genetic tools, biomolecular assays, and discrete antibody analysis to determine the mechanisms responsible for persistence of B1 cell number and function in older females so that it will be feasible to enhance B1 cell activity into old age for all.

PI_NAMEs: HOLODICK, NICHOL ELIZABETH (contact);ROTHSTEIN, THOMAS L;YOSHIMOTO, MOMOKO

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Adult;Age;age effect;age related;Age Years;aged;Aging;aging population;aging process;aging related disease;Animal Model;Antibodies;Antibody Formation;Antibody-mediated protection;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biological;Biological Assay;biological sex;Cell Count;Cell Cycle;Cell Cycle Progression;Cell Cycle Stage;Cell Physiology;Cells;Communicable Diseases;Data;Defect;design;Deterioration;Development;Disease;Disparity;Effectiveness;Elderly;Environment;epigenetic regulation;Failure;Female;fetal;Fetal Development;Frequencies;Gene Expression;Genetic;genetic manipulation;Genetic Techniques;Germ Lines;Goals;healthspan;Homeostasis;Human;human old age (65+);Immune system;Immunity;Immunoglobulin M;Infection;Inflammation;Knowledge;Life;life span;male;Measures;men;Modality;Mus;natural antibodies;Natural Immunity;Nature;novel strategies;pathogen;Persons;Phase;Pneumococcal Infections;Population;Predisposition;Prevention strategy;Property;Proteins;Publishing;Recording of previous events;Regulation;Reporting;Research;Role;self-renewal;Serology;sex;Specific qualifier value;Streptococcus pneumoniae;Structure;Testing;Time;Tissues;tool;Vaccination;Woman;women versus men

PROJECT_TITLE: The Role of Biological Sex in the Self-renewal of B1 Cells into Old Age in Mice and Humans

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative This application centers on a major gap in our understanding of the inhibitory mechanisms hampering corneal nerve regeneration. Towards this purpose, we propose to examine the role of galectin-3 in modulating the neural pathways underlying corneal disease and investigating whether therapeutic inhibition of galectin-3 improves corneal nerve regeneration and sensation. In doing so, we anticipate developing new strategies to promote and preserve normal corneal nerve density in patients with ocular surface disease.

PI_NAMEs: ARGUESO, PABLO  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Adverse effects;Afferent Neurons;Affinity;analog;Anatomy;Animal Lectins;Animal Model;Area;axon regeneration;Binding;Biology;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Cell membrane;Cell surface;Cell Survival;Cells;Central Nervous System;Chemicals;Clinical;Cornea;Corneal Diseases;corneal epithelium;corneal regeneration;Corneal Ulcer;crosslink;Data;defined contribution;Degenerative Disorder;density;Development;Dry Eye Syndromes;Epithelial Cells;Esthesia;Event;Eye;eye dryness;Eyedrops;Family;Galactose Binding Lectin;Galectin 3;Genetic;Glycoproteins;Growth;Growth Factor;Impairment;improved;In Vitro;in vivo;injury recovery;intraepithelial;Keratitis;Keratopathy;Ligands;Liquid substance;Location;Maxilla;Mechanics;member;Methods;Mus;Nerve;Nerve Growth Factor Receptors;Nerve Growth Factors;nerve injury;Nerve Plexus;Nerve Regeneration;nerve supply;Neural Pathways;Neurites;Neurodegenerative Disorders;Neuroglia;neuromechanism;Neurons;Neuropeptides;neurotrophic factor;Neurotrophic Keratitis;NGFR Protein;novel;novel therapeutic intervention;novel therapeutics;Nutrient;ocular surface;ocular surface disease;Pathogenesis;Pathologic;Patients;Peripheral;Physiological;Play;preservation;protein expression;Protein Glycosylation;receptor;Recombinants;Recovery;Regulation;reinnervation;Research;response;Role;Sensory Process;side effect;Signal Transduction;Signs and Symptoms;Structure;Structure of trigeminal ganglion;Surface;Testing;Therapeutic;therapeutic target;Topical application;transcriptional reprogramming;Trigeminal System;United States Food and Drug Administration;Viral

PROJECT_TITLE: Galectin-3 and corneal nerve regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Corticolimbic circuits play an important role in maternal care, threat and stress responses postpartum, but it is still unknown which neuronal mechanisms connect corticolimbic circuits with core maternal circuits. To this end, we will determine the role of neuroplasticity in a specific corticolimbic circuit, using a multidisciplinary approach that uniquely positions us to address these questions. It will have a significant positive impact on our mechanistic understanding of the neurobiology of the motherhood and may contribute to the design of new therapeutic approaches to prevent and decrease the incidence of mental states with similar neural mechanisms, improving well-being of mothers and their offspring.

PI_NAMEs: SHAH, PREMAL R;SHUMYATSKY, GLEB P (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;alpha Tubulin;Amygdaloid structure;Animals;Area;Behavior;Behavioral;Biochemical;biological adaptation to stress;Brain;Brain region;Candidate Disease Gene;Caring;Cell Nucleus;cell type;Cells;Chronic;Clinical;Complex;cortico-limbic circuits;Data;Data Set;Databases;density;design;Dissection;Electrophysiology (science);Emotional;experience;Female;Foundations;functional plasticity;Gastrin releasing peptide;Gene Expression;gene product;Gene Targeting;Genes;Genetic;genetic technology;Genetic Transcription;genome wide association study;Goals;GRP gene;Hippocampus;Human;human data;improved;Incidence;inhibitor;insight;interdisciplinary approach;Knock-in Mouse;Knowledge;Link;Maps;Maternal Behavior;maternal morbidity;Maternal Mortality;maternal risk;Measurement;Medial;Mediating;Mental association;Mental disorders;mental state;Messenger RNA;Microtubules;motherhood;Mothers;Mus;neural circuit;Neurobiology;neuromechanism;Neuronal Plasticity;Neurons;novel;novel therapeutic intervention;Nuclear;offspring;optogenetics;Outcome;Pathway interactions;Personal Satisfaction;pharmacologic;Physiological;Physiology;Play;Population;Positioning Attribute;Postpartum Depression;Postpartum Period;Prefrontal Cortex;Preoptic Areas;prevent;promoter;protein function;Proteins;Regulation;Research;resilience;response;ribosome profiling;Ribosomes;Rodent;Role;Signal Pathway;Signal Transduction;Source;stathmin;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptosomes;Testing;tool;transcriptome sequencing;Transgenic Mice;translational potential;Translations;Tubulin;Vertebral column;Viral;Viral Vector;Woman;Work

PROJECT_TITLE: The Role of Corticolimbic Circuits in Maternal Behavior

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative We will perform a CRISPR-based in vivo kinome screen in adult mice with optic nerve injury. The obtained hits will be used to investigate the mechanisms that mediate injury-induced neurodegeneration and regeneration failure. The most promising candidates will be further tested in a glaucoma model.

PI_NAMEs: HE, ZHIGANG  (contact);WILLIAMS, PHILIP RAYMOND

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Adult;Automobile Driving;Axon;axon injury;axon regeneration;axonal degeneration;Biosensor;Blindness;Cell Death;cell growth;cell killing;Cell Physiology;Cell Survival;cell type;Cessation of life;Clinic;Clinical Treatment;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Crush Injury;Cytoprotection;Data;defined contribution;design;Disease;disease model;druggable target;efficacy testing;Electrophysiology (science);Experimental Animal Model;experimental study;Failure;FDA approved;Genes;Genetic Transcription;Glaucoma;Guide RNA;Human;Image;imaging approach;improved;in vivo;in vivo imaging;Induced Neurons;injured;Injury;insight;Intervention;kinase inhibitor;Knock-out;Knowledge;Light;Malignant Neoplasms;Mediating;Metabolic;Metabolic stress;Metabolism;Methods;Mitogen-Activated Protein Kinases;Modeling;Molecular;Monitor;multi-electrode arrays;Mus;Natural regeneration;Nerve Crush;Nerve Degeneration;neuroprotection;novel;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Pathway interactions;Patients;Pattern;Phenotype;Phosphotransferases;Positioning Attribute;preservation;prevent;Process;programs;promoter;regenerative;Regenerative response;repaired;response;response to injury;Retinal Diseases;retinal ganglion cell degeneration;retinal ganglion cell regeneration;Retinal Ganglion Cells;Role;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STK11 gene;Stress;Survivors;Testing;Therapeutic Intervention;transcriptomics;two-photon;Validation;virtual

PROJECT_TITLE: Kinase regulators of retinal ganglion cell survival and axon regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-M (02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: FORT WORTH

ORG_NAME: COOK CHILDREN'S MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative To lessen the negative impact of drug resistant epilepsy in children, a new pre-surgical noninvasive biomarker that identifies reliably the area of the brain that generates the epileptic seizures is essential. The proposed experiments are relevant to public health because they may lead to a significant improvement of the presurgical evaluation procedure and postsurgical outcome of pediatric patients with refractory epilepsy. The project is relevant to NINDS’s mission because the resulting findings could significantly improve the quality of life in children with epilepsy, one of the most common pediatric neurological disorders, which has a major impact on children’s development and may significantly affect their adult life.

PI_NAMEs: PAPADELIS, CHRISTOS  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 18 year old;Adult;Affect;Age;Algorithms;Anatomy;Architecture;Area;Atlases;Biological Markers;Brain;Brain Mapping;Brain region;Child;Child Development;Childhood;Clinical;Data;density;Disease;effective therapy;Electroencephalography;Electromagnetics;Electrophysiology (science);Epilepsy;epileptiform;Evaluation;Event;Excision;experience;experimental study;Freedom;Frequencies;Gender;Graph;graph theory;Image;improved;innovation;instrument;interest;Intractable Epilepsy;Label;Life;Location;Magnetism;Magnetoencephalography;Maps;Measures;Mission;Monitor;National Institute of Neurological Disorders and Stroke;Nature;Nervous System Disorder;neuroimaging;neurosurgery;novel;Operative Surgical Procedures;Outcome;outcome prediction;Output;Pathologic;Patients;pediatric patients;Postoperative Period;preservation;prevent;Procedures;Public Health;Publishing;Quality of life;Reporting;Research;Rest;Seizures;Selection Bias;sensor;signal processing;Source;spatiotemporal;Specificity;success;surgery outcome;Techniques;Testing;tool;virtual;Weight

PROJECT_TITLE: Noninvasive Mapping of Functional and Effective Connectivity in Children with Drug Resistant Epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: The objective of this project is to define the functional significance of a transcription factor in controlling astrocyte homeostasis and function under healthy and diseased condition. Our project is relevant to public health because it will likely provide new insights into future therapeutic options by harnessing this molecule to mitigate or reverse the disease severity of inflammatory demyelinating disorders.

PI_NAMEs: GUO, FUZHENG  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adopted;Adult;Affect;Anatomy;Animal Behavior;Astrocytes;Behavioral;Binding;Biohazardous Substance;Bioinformatics;Biological;Biological Process;Biology;Brain;Budgets;Cells;Central Nervous System;central nervous system demyelinating disorder;Clinical;Cognition;cohort;Complement 3;complement pathway;Complex;conditional knockout;Data;Demyelinating Diseases;Demyelinations;Development;Disease;Electrophysiology (science);Excision;Experimental Autoimmune Encephalomyelitis;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Models;genetic signature;glial cell development;Glial Differentiation;Goals;Homeostasis;Human;human subject;Hyperactivity;Image;In Vitro;Inflammatory;inflammatory modulation;Injury;insight;Ions;Knockout Mice;Knowledge;Link;member;Membrane;Modeling;Molecular;Morphology;Motor;motor control;mouse genetics;mouse model;Multiple Sclerosis;Mus;Natural regeneration;nerve stem cell;Nervous System Disorder;Nervous System Trauma;Neuroglia;neuroprotection;neurotoxic;Neurotransmitters;next generation sequencing;novel;Nuclear;Output;Pathology;Pathway interactions;Phenotype;Play;pluripotency;Property;Public Health;Regulatory Element;Reporting;Repression;Research Personnel;response;Role;Severity of illness;Shapes;Symptoms;Synaptic Transmission;synaptogenesis;Testing;Therapeutic;Time;timeline;Tissue-Specific Gene Expression;transcription factor;two-photon;Vertebrates;Work

PROJECT_TITLE: SOX2-regulated astrocyte homeostasis and pathophysiology

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Mitochondrial dysfunction is increasingly associated with many currently incurable late-onset diseases such as Alzheimer’s disease, heart disease, and cancer. Preliminary results suggest that mitochondrial dysfunction causes molecular oxygen-mediated tau hyperphosphorylation, aggregation, and proteotoxicity – which is thought to be a leading cause of Frontotemporal Lobar Degeneration, Alzheimer’s Disease, and other tauopathies. This proposal aims to mechanistically understand these phenomenological results and stands to enable the rational pursuit of innovative approaches to prevent tauopathies.

PI_NAMEs: GRILLO, ANTHONY STEVEN (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Achievement;Acute;Age;aging related;aging related disease;Alzheimer's Disease;astrogliosis;Automobile Driving;Basic Science;Binding Proteins;Biology;Body fat;Body Weight decreased;Brain;brain tissue;Cells;Cessation of life;Chemicals;Chronic;Cognition;combat;Communication;Complex;Data;Dementia;Development;Disease;disease phenotype;Electron Transport;Equilibrium;Event;Exhibits;experimental study;extend lifespan;Failure;follow-up;Frontotemporal Lobar Degenerations;Functional disorder;Generations;Genetic;glial activation;glycogen synthase kinase 3 beta;Goals;Heart Diseases;Hippocampus;Housing;Human;Hyperoxia;hyperphosphorylated tau;Hypoxia;Image;Impaired cognition;improved;in vivo;Inclusion Bodies;Induced pluripotent stem cell derived neurons;innovation;insight;Intervention;Knock-out;Knockout Mice;Late-Onset Disorder;Leigh Disease;Lesion;life span;Lipid Peroxidation;Literature;Malignant Neoplasms;Mediating;Mediator;Metabolism;metabolomics;Microtubules;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Modeling;Molecular;mortality;mouse model;Mus;NADP;NADPH Oxidase;Nematoda;Nerve Degeneration;neuroinflammation;neuron loss;Neurons;normal aging;old mice;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxygen;oxygen toxicity;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;phenomenological models;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiology;Play;premature;prevent;Prevention;Production;progressive neurodegeneration;Protein Isoforms;protein kinase A kinase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;proteotoxicity;Proto-Oncogene Proteins c-akt;Reaction;Regimen;Role;Rotenone;Signal Pathway;Signal Transduction;Site;tau aggregation;tau mutation;tau Proteins;tau-1;tau-protein kinase;Tauopathies;Testing;Toxic effect;Transgenic Organisms;two-photon;Work

PROJECT_TITLE: Probing the Influence of Oxygen Toxicity on Tau Hyperphosphorylation caused by Mitochondrial Dysfunction


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Under-diagnosis occurs when an individual living with a medical condition has not been diagnosed. Overlooking of diagnosis prevents patients from opportunities of appropriate treatments and prevention strategies, and often is more serious in some population subgroups. Recent emphasis on electronic health records (EHRs) provides a unique opportunity for addressing under-diagnosis, which to date remains largely unexploited due to lack of suitable analytical methods. The overarching goal of this project is to develop data-driven methods to accurately identify patients from EHRs who possibly miss their diagnosis and provide insights for reasons of under-diagnosis.

PI_NAMEs: CHEN, JINBO  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;analytical method;Clinical;Communities;Complex;Computer software;Data;Development;Diagnosis;Disease;disease diagnosis;disorder risk;Disparity;Electronic Health Record;electronic structure;Ethnic Origin;Familial Hypercholesterolemia;Feedback;future implementation;Goals;health care disparity;health care settings;Health Insurance;high dimensionality;Hospitals;Hyperaldosteronism;improved;Individual;insight;Insurance Coverage;Label;Laboratories;machine learning algorithm;machine learning method;Medical;Medicine;Methodology;Methods;Mission;Modeling;novel;operation;patient health information;patient subsets;Patients;Physicians;Population;predictive modeling;prevent;Prevention strategy;Process;Property;Publications;Regression Analysis;Research Design;Risk;Risk Assessment;Risk Estimate;screening;sex;Software Tools;statistical and machine learning;Statistical Methods;Structure;Subgroup;Symptoms;Testing;treatment strategy;user friendly software

PROJECT_TITLE: Statistical Methods for Addressing Disease Under-diagnosis Using Electronic Health Record Data

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_DEPT: BIOLOGY

ORG_STATE: MO

PHR: Project Narrative Glioblastoma (GBM) is a deadly disease with median survival post-treatment of 15 months, and no major advancements in therapy in the past decade. Based on the recent discoveries that neuronal activity promotes GBM growth and murine and human models of GBM have cell-intrinsic circadian rhythms that synchronize to the host, we propose to identify daily signals that entrain GBM cells and promote growth. The findings from these experiments should reveal treatments that slow tumor progression to improve individual patient outcomes.

PI_NAMEs: HERZOG, ERIK  (contact);RUBIN, JOSHUA B

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Acceleration;Affect;Aftercare;Apoptosis;Area;ARNTL gene;Behavior;Biology;Brain;Brain Neoplasms;brain-derived growth factor;breast cancer metastasis;Caring;Cell Death;Cell Line;Cell Reprogramming;Cells;chemotherapy;Child;Chronotherapy;circadian;circadian pacemaker;Circadian Rhythms;Clinical;clinical care;Clinical Trials;Colorectal Cancer;Data;design;Developmental Process;Diagnosis;Disease;disease model;Disease Progression;Engineering;experimental study;Female;gain of function;Gene Expression;Genes;Genetic Engineering;Glioblastoma;Glioma;Glucocorticoids;Growth;hormonal signals;Human;human model;Hypothalamic structure;Immune mediated destruction;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;individual patient;inhibitor;Intervention;Investigation;Knowledge;Lesion;leukemia;loss of function;male;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;malignant state;Measures;Metabolism;Mitogens;Mitosis;Molecular Target;mouse model;Mus;Mutation;neoplastic cell;neural;neuro-oncology;neuroligin 3;Neurons;new therapeutic target;novel;Oncology;optimal treatments;optogenetics;Outcome;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Physiology;precursor cell;Proliferating;receptor;Recurrence;Reporter;Rest;Retrospective Studies;Role;Sex Differences;sexual dimorphism;Signal Transduction;Sleep;stem cells;success;suprachiasmatic nucleus;System;temozolomide;Testing;Therapeutic;therapeutic target;Time;Tissues;Translating;translational applications;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;Vertebrates;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Circadian interventions against glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Precision Medicine;Sepsis

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Sepsis is a life-threatening infection that affects many children and can frequently result in the failure of multiple organs, such as the lungs, heart, or kidneys. There are no existing effective treatments that are specifically designed for sepsis, but there is evidence that some subgroups of patients with sepsis respond differently to some treatments, including a subgroup with persistent lung and heart failure that we have previously described. We propose developing and testing an algorithm that can predict which children with infections will develop this specific high-risk type of sepsis and studying what treatments appear to result in more benefit using the medical records of tens of thousands of children with infections receiving care in an intensive care unit.

PI_NAMEs: SANCHEZ-PINTO, LAZARO NELSON (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Accounting;Adjuvant Therapy;Admission activity;Adult;Affect;Albumins;Algorithms;Area;Caring;Cause of Death;Cessation of life;Characteristics;Child;Classification;Clinical;Clinical Data;Clinical Trials;Consensus;cost effective;Country;Critically ill children;Data;Derivation procedure;design;Development;Early identification;effective therapy;Electronic Health Record;Endothelium;Enrollment;Fluid Balance;Functional disorder;Future;Goals;Heart;Heart failure;Heterogeneity;high risk;Hour;Hydrocortisone;Hypoxemia;Income;Infection;Inflammation;Infrastructure;Institution;Intensive Care Units;interest;Intervention;Intravenous;Kidney;Life;Liquid substance;low and middle-income countries;Lung;lung failure;machine learning prediction;Medical Records;Modeling;mortality;Multicenter Studies;Multiple Organ Failure;National Institute of Child Health and Human Development;Organ;Outcome;Output;patient subsets;Patients;Pediatric Intensive Care Units;pediatric sepsis;Performance;Phenotype;Population;Positive-Pressure Respiration;precision medicine;predictive modeling;Predictive Value;pressure;Probability;prognostic;prospective;Public Health;quality assurance;Randomized, Controlled Trials;Reproducibility;Research;Research Priority;Sepsis;sepsis induced ARDS;Severity of illness;Shock;Site;Subgroup;systemic inflammatory response;Testing;Therapeutic;therapeutic target;Time;treatment effect;Validation

PROJECT_TITLE: Phenotype prediction and therapeutic targets in high-risk pediatric sepsis-associated MODS

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project narrative (relevance): Despite appropriate treatments, chronic blood disorders such as chronic myelogenous leukemia (CML) and other myeloproliferative neoplasms (MPN) can transform into more aggressive conditions, i.e., respectively blast crisis (BC) CML or secondary acute myeloid leukemia (sAML), which are very poorly responsive to currently available treatments. This proposal seeks to understand the mechanisms through which deficit of a molecule called miR- 142 causes a loss of function of the immune system that favors BC/sAML transformation and to target these mechanisms with new approaches that address the otherwise unmet need for effective therapies for patients with these conditions. To this end, we will develop a novel drug called CpG-M-miR-142 to restore levels of miR- 142, enhance immune system function and eventually block disease transformation in these otherwise poor-risk patients.

PI_NAMEs: MARCUCCI, GUIDO ;ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Lymphocytic Leukemia;adaptive immunity;Address;antileukemic activity;bcr-abl Fusion Proteins;Blast Phase;Bone Marrow;cancer stem cell;CD34 gene;Cell Physiology;Cells;Chronic;Chronic Myeloid Leukemia;Chronic Phase;Chronic-Phase Myeloid Leukemia;design;Development;Disease;disease phenotype;Down-Regulation;effective therapy;Evolution;exhaust;exhaustion;Functional disorder;gene conservation;Goals;Growth;Hematological Disease;Hematopoiesis;Hematopoietic;Human;Immune;immune system function;Immune Targeting;Immunity;Immunologic Surveillance;In Vitro;in vivo;insight;Institution;leukemia;leukemic stem cell;leukemic transformation;loss of function;Lymphoma;Lymphopenia;Malignant - descriptor;manufacture;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Myeloproliferative disease;Names;Natural Immunity;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;patient derived xenograft model;Patients;PD-1 inhibitors;Phenotype;Play;prevent;programmed cell death protein 1;Proteins;Refractory;Regulation;Reporting;Risk;Role;Secondary acute myeloid leukemia;T-Lymphocyte;targeted treatment;Therapeutic;Time;Tyrosine Kinase Inhibitor;Untranslated RNA

PROJECT_TITLE: Targeting Immune Escape in CML/MPN Transformation

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE Diastolic heart disease (DHD) is the leading cause of death and disability worldwide. Diastolic dysfunction is caused by stiffening of the heart and impaired relaxation which occur by unknown molecular mechanisms. In this proposal, the PI and colleagues determine if cardiac microtubules underlie diastolic dysfunction in DHD. In Aim 1 they demonstrate that hypertension and metabolic syndrome are cooperative stabilizers of the cardiac microtubule network and determine if cardiac microtubules are molecular regulators of myocyte and myocardial stiffness. In Aim 2 the PI and colleagues leverage newly developed working myocardial preparation to quantify the cardiac microtubules influence on diastolic performance in normal, hypertensive and DHD myocardium. Together, the results determine the contribution of cardiac microtubules to diastolic dysfunction and demonstrate the potential for microtubule target drugs as a new class of therapies for DHD.

PI_NAMEs: CAPORIZZO, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actomyosin;Basic Science;Biological Assay;Biology;Biomechanics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cause of Death;Clinical;Clinical Data;Colchicine;Collagen;connectin;Contracts;Custom;Cytoskeletal Filaments;Data;density;depolymerization;design;Diastole;disability;Drug Targeting;Enzymes;Excision;Exhibits;extracellular;FDA approved;Fibrosis;force feedback;Functional disorder;Health;Heart;Heart Diseases;Heart failure;Histology;Hypertension;hypertensive;Hypertrophy;Impairment;improved;Left ventricular structure;mechanical properties;Mechanics;Metabolic syndrome;Microtubules;Minority;Modeling;Molecular;Muscle;Muscle Cells;Myocardial;Myocardium;Network-based;novel;Output;Performance;Periodicity;Phase;Physiology;Play;Preparation;Property;Protein Isoforms;Proteins;Proteomics;Protocols documentation;Rattus;Regulation;Relaxation;Role;Sarcomeres;Series;Slice;Speed;Stretching;Structure;superresolution imaging;targeted treatment;Testing;Translating;Tubulin;United States National Institutes of Health;Ventricular;Work

PROJECT_TITLE: Cardiac microtubules as regulators of diastolic function.

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endometriosis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pain Research;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Endometriosis is a common but poorly understood condition, particularly in non-Whites, that is benign, and often harbors mutations in “driver” genes. This Study will use state-of-the-art single cell transcriptomics, epigenomics, exome-sequencing and a bioluminescent transplant model to catalogue somatic mutations across a diverse cohort of patients and dissect consequences of somatic mutations to identify new therapeutic opportunities. These insights are expected to pave the way to the development of precision medicine for endometriosis.

PI_NAMEs: ANGLESIO, MICHAEL STEPHEN;LAWRENSON, KATE  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Address;Affect;African American population;Age;Alleles;Animal Model;Anxiety;ARID1A gene;Asian;Asian population;Asian Women;Benign;black women;Catalogs;Cell Communication;Cell Compartmentation;cell type;Cells;central pain;Chronic;Chronic Disease;chronic pain;clinical care;cohort;comorbidity;Data;Development;Diagnosis;Disease;driver mutation;Dysmenorrhea;endometriosis;epigenomics;Epithelial Cells;Epithelium;ethnic diversity;European ancestry;eutopic endometrium;exome sequencing;experience;Fatigue;Female infertility;Financial Hardship;follow-up;Frequencies;functional genomics;gastrointestinal;Genes;Genetic;Genomics;Goals;Gynecologic;Health Services Accessibility;Hemorrhage;Heterogeneity;Hispanic Populations;Hispanic Women;Hormone Responsive;Immune;in vivo;Individual;individualized medicine;Infertility;Inflammatory;innovation;insight;intercellular communication;Invaded;KRAS2 gene;Lesion;Life;Ligands;Lymphatic Endothelial Cells;Maps;Mental Depression;Metabolic;Methodology;Modeling;Modification;Molecular;Molecular Profiling;Monitor;mouse model;mutant;Mutation;novel;novel therapeutics;Pain;paracrine;Pathogenesis;Pathway interactions;Patients;personalized medicine;PIK3CA gene;Population;Population Heterogeneity;precision medicine;Prevalence;programs;PTEN gene;Questionnaires;racial difference;racial diversity;reproductive;Resources;Role;sample collection;Sampling;Signal Transduction;single cell genomics;Site;Somatic Mutation;Standardization;Symptoms;Syndrome;targeted sequencing;Technology;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Therapeutically Targetable;Tissues;transcriptomics;Translating;transplant model;Transplantation;Uterus;White Women;Woman

PROJECT_TITLE: Functional Genomics Across an Ethnically and Racially Diverse Endometriosis Population

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Nutrition;Prevention

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: NARRATIVE Acute pancreatitis (AP) is a common and serious condition, accounting for more than 300,000 hospitalizations and over $2 billion in health care costs per year in the United States alone. Patients with AP have an increased risk of diabetes (DM) which increases morbidity, mortality and costs. The overarching goal of this proposal is to determine whether continuous glucose monitoring (CGM) would be clinically useful to predict risk for developing DM, the need for insulin therapy and subtype of DM among patients who have experienced an episode of AP. This could support the use of CGM in routine care for patients who have experienced an episode of AP to diagnose DM at an early stage and predict likely need for insulin therapy.

PI_NAMEs: CHINCHILLI, VERNON M (contact);PRATLEY, RICHARD E

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Accounting;acute pancreatitis;Address;Adult;age related;Ancillary Study;Autoimmunity;Beta Cell;Cell Physiology;chronic pancreatitis;Classification;Clinical;clinical research site;clinical risk;Complement;Continuous Glucose Monitor;cost;Data;design;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Enrollment;Etiology;Exocrine pancreatic insufficiency;experience;fasting plasma glucose;follow-up;Functional disorder;Genetic Predisposition to Disease;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Health Care Costs;high risk;Hospitalization;Immune;Incidence;indexing;Individual;innovation;insight;Insulin;Insulin deficiency;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;intravenous glucose tolerance test;islet cell antibody;Knowledge;Measures;Meta-Analysis;Metabolic;Mild obesity;Modeling;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Necrosis;novel;observational cohort study;Observational Study;OGTT;Outcome;Pancreas;pancreas imaging;Pancreatitis;Participant;participant enrollment;Pathogenesis;Patient Care;Patients;Pilot Projects;Population;Prediabetes syndrome;Predictive Factor;prospective;Prospective, cohort study;Recommendation;Reporting;Research;Risk;risk prediction;routine care;Sampling;Schedule;screening;Severities;Standardization;Testing;Time;Uncertainty;United States;United States National Institutes of Health;Visit

PROJECT_TITLE: Diabetes RElated to Acute Pancreatitis and its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics (DREAM-ON)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Over 700,000 U.S. hairdressers are likely exposed to mixtures of chemicals which could impact lung health. This will be the first study to comprehensively assess personal and workplace behaviors and occupational exposures to chemicals commonly found in salon settings (phthalates and volatile organic compounds) in a racially and ethnically diverse hairdresser cohort, and to examine their association with early markers of respiratory disease, lung function and respiratory symptoms. Findings from this work will have direct public health implications by informing effective interventions and federal policies to protect vulnerable populations and addressing exposures that impact population health.

PI_NAMEs: QUIROS-ALCALA, LESLIAM  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Address;Adjuvant;Adult;Affect;air sampling;airway inflammation;airway remodeling;Animals;Asthma;Behavior;Behavior assessment;Biological;biological adaptation to stress;Biological Markers;Biological Monitoring;Biological Response Modifiers;Black race;Cause of Death;Characteristics;Chemical Exposure;Chemicals;Chronic;Chronic lung disease;chronic respiratory disease;cohort;Color;community partnership;Data;disability;disorder control;disorder prevention;disorder risk;disparity reduction;early detection biomarkers;Early identification;effective intervention;Employment;Ensure;Epidemiology;Epithelial Cells;ethnic diversity;Ethnic Origin;Exhalation;experience;Exposure disparity;Exposure to;Faith;federal policy;Goals;Hair;Health Expenditures;health inequalities;Hour;Immunology;immunoregulation;in vivo;Individual;Inflammation;Inflammation Mediators;inflammatory marker;Inflammatory Response;Inhalation Toxicology;Intervention;Isoprostanes;Latina;Link;Liquid substance;Lung Diseases;lung health;Marketing;Measurement;Measures;Methods;modifiable risk;multidisciplinary;Nasal Epithelium;Nitric Oxide;novel;Occupational Exposure;Occupational Health;Oxidative Stress;Oxidative Stress Induction;people of color;personal protective equipment;phthalates;Population;population health;Populations at Risk;Prevalence;Property;Public Health;public health intervention;pulmonary function;Pulmonology;Questionnaires;Race;racial diversity;Reporting;Reproducibility;respiratory;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;Risk;Risk Factors;Role;Sampling;Science;secondary analysis;social health determinants;Spanish;Spirometry;targeted biomarker;toxicant;Underrepresented Populations;Urine;ventilation;volatile organic compound;Vulnerable Populations;Woman;Work;Workplace

PROJECT_TITLE: The MELENA Study: Measurement of Exposures, Lung hEalth, and functioN in hAirdressers

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Human stem cell-derived three-dimensional (3D) models of the brain do not fully recapitulate the composition of progenitor cells present in the developing human cortex and the signals produced by non-neural cell types. Here, we will generate a 3D, microphysiological model of the brain that recapitulates human cortical development at improved resolution by producing a broader diversity of progenitor and neuronal cell populations (outer radial glia, cortical interneurons, mature cortical excitatory neurons), and by integrating signals from non-neuronal cell types (vascular and immune cells). This project addresses a major bottleneck in human stem biology and should result in better tools to study neurodevelopmental and cognitive disorders in the future.

PI_NAMEs: STUDER, LORENZ P. (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Behavior;Biological Models;Biology;Blood Vessels;Brain;brain pericytes;Brain region;Cell Line;cell type;Cells;Central Nervous System;cerebrovascular;Cerebrum;Cognition Disorders;Complex;Defect;Derivation procedure;Development;differentiation protocol;directed differentiation;Disease;Equilibrium;excitatory neuron;fetal;FRAP1 gene;Future;Generations;Genetic;Human;human data;human pluripotent stem cell;human stem cell-derived;human tissue;Immune;improved;Individual;Interneurons;LIF gene;Ligands;Link;Maps;Microglia;microphysiology system;Modeling;mTOR Signaling Pathway;Mus;neural;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;novel;Organoids;Pathology;Patients;Pattern;Pericytes;Peripheral Nervous System Diseases;Phenotype;physiologic model;Population;progenitor;Protocols documentation;Radial;Reporter;Reporting;Reproducibility;Research Personnel;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Source;spheroids;STAT3 gene;stem;stem cell model;stem cell organoids;stem cells;Supplementation;System;Testing;three-dimensional modeling;Tissues;tool;Translating;Treatment Factor;Treatment Protocols;Tuberous Sclerosis;tuberous sclerosis patients;two-dimensional;Work

PROJECT_TITLE: Human PSC-based cortical organoid and assembloid systems integrating pericyte and microglial lineages and signals


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Infant Mortality;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: BOISE

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE This project is relevant to public health because it will quantify the influence of Sudden Unexpected Infant Death (SUID) biomechanical factors on respiration in infants. This study will provide a foundational understanding and translational knowledge for clinicians, parents, and infant product designers to reduce the risk of SUID from a novel biomechanics perspective.

PI_NAMEs: MANNEN, ERIN  (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Abdomen;Adolescent;Affect;Age;Asphyxia;Back to Sleep;Biomechanics;body position;Breathing;caregiving;Cessation of life;Chest;Childhood;Classification;Complex;Complication;Computer Models;consumer product;Data;design;Development;Educational workshop;Event;evidence base;Experimental Models;feeding;Flexor;Goals;Guidelines;hazard;Head and neck structure;human subject;in vivo;Individual;Industry;Infant;Infant Care;Infant Development;Infant Mortality;Injury;insight;kinematics;knowledge translation;Life;Manufacturer;Marketing;mortality risk;multidisciplinary;Muscle;novel;Outcome;Parents;Play;Positioning Attribute;Premature Infant;prevent;Prevention strategy;Public Health;Pulmonology;Research;Research Personnel;Research Project Grants;Respiration;respiratory;Risk Factors;Risk Reduction;Role;Science;Sleep;Statutes and Laws;Sudden infant death syndrome;Supination;Surface;Techniques;Testing

PROJECT_TITLE: Quantifying the effect of biomechanical SUID risk factors on infant respiration

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Colon cancer is among the leading causes of death worldwide and host-bacterial microbiota immune interactions profoundly influence tumorigenesis, cancer progression and response to therapies. Nevertheless, the role of fungi (mycobiota) in these processes remain largely unexplored, missing a potential opportunity for developing novel diagnostic, preventative, and therapeutic strategies. Upon providing the first evidence for association of specific fungi with gastrointestinal cancers here we aim to define central mechanisms of mycobiota interactions within colorectal tumors to understand their role in cancer and therapy.

PI_NAMEs: ILIEV, ILIYAN DIMITROV (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Algorithms;anti-cancer therapeutic;anti-fungal agents;anti-PD-1;Antifungal Therapy;arm;Atlases;Bacteria;bioinformatics pipeline;Biological Markers;Biological Response Modifiers;biomarker performance;Blood;Cancer Model;cancer therapy;cancer type;Candida;Cause of Death;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Colorectal Neoplasms;Complex;cost;CRISPR/Cas technology;Data;Development;Diagnostic;Environment;Etiology;Fungal DNA;fungal microbiota;fungus;genetic manipulation;Genetic Models;Genetic Transcription;genome wide association study;Goals;Growth;host microbiota;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunology;Immunotherapy;Implant;In Vitro;in vivo Model;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;Metabolic;Methodology;microbiome;microbiota;Modeling;mouse model;Mucous Membrane;Mus;mycobiome;Mycotoxins;neoplasm immunotherapy;Newly Diagnosed;novel;novel diagnostics;Outcome;Pathway interactions;Patients;Phenotype;Play;Population;Process;prognostic;Regulation;Research;response;Role;Side;Site;Spatial Distribution;subcutaneous;System;Therapeutic;therapy outcome;tool;treatment response;tumor;tumor growth;Tumor Markers;tumor microenvironment;tumor progression;tumorigenesis;Virulence Factors;Work

PROJECT_TITLE: The role of the mycobiome in cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE:  Amyloid-β (Aβ) accumulation as toxic oligomers and plaques are hallmark pathological changes that occur early in an Alzheimer’s disease brain and progress throughout the course of disease. This proposal will determine if elevated synaptic activity, a basic function of the brain in action, not only causes formation of Aβ but also induces it to aggregate into toxic species. Furthermore, we will determine which neuronal type produces these aggregates and if chronic modulation of specific neurons has a long-term impact on Aβ plaques.

PI_NAMEs: CIRRITO, JOHN R (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;abeta oligomer;Acute;Age;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-42;Amyloid beta-Protein;amyloid formation;Amyloidosis;Apolipoprotein E;awake;Behavior;beta amyloid pathology;Biochemical;biomarker discovery;biophysical analysis;Brain;Brain region;Cell Death;Cell surface;cell type;Cerebrospinal Fluid;Chronic;Clinical;Data;dentate gyrus;designer receptors exclusively activated by designer drugs;Detection;Development;Disease;Disease Progression;disorder risk;drinking water;effective therapy;Electric Stimulation;Endocytosis;Endosomes;entorhinal cortex;excitatory neuron;Extracellular Space;Frequencies;Functional disorder;Future;Generations;Glutamates;Hippocampus;Hour;Human;Immunofluorescence Immunologic;In Vitro;in vivo;Inflammation;inhibitory neuron;Intercellular Fluid;Knock-in Mouse;late endosome;Link;Location;Measures;Molecular Chaperones;Molecular Conformation;Monitor;Monoclonal Antibodies;monomer;mouse model;Mus;Neurofibrillary Tangles;Neurons;new therapeutic target;novel;novel marker;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peptides;Pharmacology;Physiological;Physiological Processes;Population;preservation;prevent;Probability;Property;receptor;Recycling;Regulation;Research Design;Risk Factors;secretase;Senile Plaques;Sleep;Source;Specificity;Symptoms;Synapses;tau Proteins;Technology;Therapeutic Agents;Time;Viral;Virus

PROJECT_TITLE: Synaptic activity-driven Abeta generation and aggregation

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Narrative Virus-associated glomerular diseases are seen in increasing frequency in clinical practice with underlying mechanisms still unclear. We have identified a unique viral-host immune interplay that drives the glomerular integrin activation. In this project, we will determine the mechanisms and therapeutic implication of targeting viral protein-host suPAR-integrin axis for better understanding and management of virus-associated glomerular diseases.

PI_NAMEs: WEI, DAVID CHANGLI (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: 2019-nCoV;Affinity;Animal Model;Antibodies;Binding;burden of illness;Cell-Matrix Junction;Cells;Chronic Kidney Failure;Clinical;clinical practice;Communicable Diseases;Coupled;COVID-19 pandemic;COVID-19 patient;Data;Devices;Disease;efficacy evaluation;Epitopes;Exposure to;Fc Receptor;Foot Process;Frequencies;Functional disorder;glomerular filtration;Glomerular Filtration Rate;Hantavirus Infections;HIV Envelope Protein gp120;HIV-1;Hospitalization;Human;Human Herpesvirus 4;Immune;Immune system;Immunity;Impairment;In Vitro;in vivo;Infection;Influenza B Virus;Injections;Injury;innovation;insight;Integrin Binding;Integrin Inhibition;Integrins;Interleukin-5;Kidney;Kidney Diseases;loss of function;Modality;Modeling;Molecular;Monitor;mouse model;Mus;new therapeutic target;next generation sequencing;novel;novel therapeutics;overexpression;Patients;Photometry;Play;podocyte;Proteins;Proteinuria;Publishing;renal damage;Renal function;Renal glomerular disease;Research;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Scanning;Serology;severe COVID-19;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;synergism;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;tool;Ultrafiltration;Urokinase Plasminogen Activator Receptor;Viral;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Viral-immune interaction in glomerular kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health;Teenage Pregnancy

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: AIM-UP Narrative: AIM-UP will combine data from nine large-scale teen pregnancy prevention projects to describe the use, examine the effectiveness, and describe approaches to adaptations of evidence-based programming for four youth at high-risk for unintended pregnancy. Using the FRAME framework, the project examines adaptations in the following four areas: (1) trauma and system involvement; (2) diversity, equity, inclusion and justice; (3) implementing in rural communities; and (4) adapting for virtual delivery. Effective adaptations will be translated into a toolkit using the Delphi approach for adapting evidence-based programs to local contexts.

PI_NAMEs: OTT, MARY A. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adolescent;adolescent birth rate;Area;Assessment tool;Attitude;Behavior;Black race;Categories;Characteristics;Child Welfare;Collection;Communities;community collaboration;community setting;Country;Data;demographics;design;Development;Disparity;Drops;E-learning;Educational Curriculum;effectiveness evaluation;effectiveness trial;equity, diversity, and inclusion;evidence base;Evidence based program;experience;Exposure to;Frequencies;Funding;gender diverse;Geographic Locations;Goals;health disparity;Healthcare;high risk;improved;Income;Indiana;Interview;Justice;juvenile justice system;Knowledge;Latino;Latinx;Lesbian Gay Bisexual;Life;Location;Measures;medical schools;Methods;Modification;Monitor;Participant;Performance;Population;Population Heterogeneity;Pregnancy in Adolescence;pregnancy prevention;Prevention program;Process;process evaluation;programs;prospective;queer;Recording of previous events;Reporting;Research;Resources;Rural;Rural Community;rurality;Schools;skills;Social Environment;stakeholder perspectives;Surveys;System;Testing;Time;Training and Education;Translating;Trauma;unintended pregnancy;United States;Universities;virtual;virtual delivery;Youth

PROJECT_TITLE: Adaptations and Impacts Understanding Teen Pregnancy Prevention Programs

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE The basal ganglia are involved in many motor and non-motor functions, including the regulation of valence and mood. This project will study, in non-human primates, the anatomical connections and parkinsonism-associated pathophysiological changes of pallidal projections to the lateral habenula, which is involved in the processing of negative valence. Results of this project will further our understanding of the pathophysiology of the palllidohabenular projection in parkinsonism, and may help us to better understand the origin of some of the psychiatric aspects of Parkinson’s disease, such as depression.

PI_NAMEs: GALVAN, ADRIANA ;SMITH, YOLAND  (contact);WICHMANN, THOMAS

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 3-Dimensional;Affect;affective disturbance;Anatomy;Anhedonia;Animals;Architecture;Area;Basal Ganglia;Behavior;Behavioral;Brain Stem;Cell Communication;Cell Nucleus;Cells;Chemicals;Cognition;Communication;Corpus striatum structure;Data;Deep Brain Stimulation;depressive symptoms;Development;Dopamine;Electric Stimulation;Electrodes;Electrophysiology (science);experimental study;Food Preferences;Functional disorder;gamma-Aminobutyric Acid;Ganglia;Glutamates;Goals;Habenula;Heterogeneity;Immunoelectron Microscopy;in vivo;Knowledge;Label;Lateral;Literature;Macaca mulatta;Mental Depression;Methods;Modeling;Monkeys;Moods;Morphology;Motor;Movement;MPTP treatment;Negative Valence;nerve supply;Neurons;Neurotransmitters;nonhuman primate;Opsin;Output;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathologic;Patients;Pattern;Phenotype;Play;Population;Population Projection;Prevalence;Primates;rate of change;Regulation;Resolution;response;Rewards;Rodent;Role;Scanning Electron Microscopy;Signal Transduction;Stains;STN stimulation;Structure of subthalamic nucleus;Subthalamic structure;Synapses;Synaptic Transmission;System;Testing;Thalamic structure;Viral Vector;Work

PROJECT_TITLE: The Pallidohabenular System in Parkinsonism

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Existing therapeutic interventions for single ventricle congenital heart defects, including synthetic or tissue- engineered vascular conduits made by seeding autologous patient bone marrow cells onto biodegradable polymeric tubular scaffolds, are insufficient for effective patient care due to vulnerability to infection, thrombosis, inability to grow, or a high incidence of graft stenosis after transplantation. Native blood vessel scaffolds and human induced pluripotent stem cell (hiPSC)-derived endothelial cells, capable of mitigating thrombosis and cellular over-proliferation during vascular conduit generation, may offer an opportunity to effectively address the above challenges. This project describes our efforts to develop universal, hypoimmunogenic contractile conduits based on hiPSC-derived cardiomyocytes, cardiac fibroblasts, and endothelial cells that can prevent graft stenosis and provide pumping activity to assist blood flow through both in vitro assays and in vivo implantation into an immune-humanized rat model.

PI_NAMEs: QYANG, YIBING  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Ablation;Address;Affect;Autologous;biodegradable polymer;Biological;bioluminescence imaging;Bioreactors;Blood;Blood flow;Blood Vessels;Bone Marrow Cells;Cardiac;Cardiac Myocytes;cardiac tissue engineering;CD47 gene;Cell Differentiation process;Cell Line;Cell Lineage;Cell Survival;cell type;Cells;Child;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;curative treatments;Death Rate;Defect;Diameter;Ectopic Expression;Emergency Situation;Endothelial Cells;Endothelium;Excision;Family suidae;Female;Fiber;Fibroblasts;follow-up;Fontan Procedure;Foundations;Future;Gene Expression;Generations;Genes;Growth;Harvest;Heart;Heart failure;Histocompatibility Antigens Class I;Histologic;HLA Antigens;Human;human induced pluripotent stem cells;Immune;immunogenicity;Implant;implantation;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;Individual;induced pluripotent stem cell derived cardiomyocytes;Infection;Inferior vena cava structure;Inflammation;Inflammatory Response;insight;interest;Legal patent;Live Birth;Luciferases;Lung;male;mechanical stimulus;Mechanics;Mediating;Modeling;Monitor;nonhuman primate;Nude Rats;Operative Surgical Procedures;Output;palliative;Patient Care;Patients;Performance;Perfusion;Phagocytosis Inhibition;Physiological;pluripotency;Polymers;pressure;prevent;Production;Proliferating;Property;Pulmonary artery structure;Pulmonary Circulation;pulmonary vascular disorder;Pump;Rattus;repaired;Reporter;Reporting;scaffold;self-renewal;shear stress;Single ventricle congenital heart disease;Skin;Somatic Cell;Stem Cell Factor;Stenosis;Structure of umbilical artery;Study models;Testing;Therapeutic;Therapeutic Intervention;Thrombosis;Thymidine Kinase;Tissue Engineering;tissue stem cells;Tissues;Training;Transplantation;Treatment Efficacy;Tubular formation;ultrasound;Vascular Endothelium;vascular tissue engineering;Venous

PROJECT_TITLE: Readily Available Biological Conduits to Treat Single Ventricle Defects

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Narrative Reversible shape changes of arteries, which allow for efficient blood circulation, is provided to tissues by elastin, a protein polymer whose structure was not fully resolved. Through advanced experimental and modeling methods, we will determine the structure and function of the entire polymer of healthy elastin with age/disease-associated modifications and characterize the molecular mechanisms of arterial dysfunction associated with aging and disease.

PI_NAMEs: TARAKANOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Adsorption;Affect;Age;age effect;age related;age-related disease;aged;Aging;aging related;Architecture;Arteries;Automobile Driving;Behavior;Binding;Biochemical;Biological;Biological Aging;Biological Assay;biomechanical test;Blood Circulation;calcification;Calcium;Calibration;Cardiovascular system;Circular Dichroism;Collagen;Complex;Computer Models;Connective Tissue;Coupled;Coupling;crosslink;Data;density;Development;Diagnosis;Diagnostic;dimer;Disease;Elastic Fiber;Elastic Tissue;Elasticity;Elastin;Environment;Experimental Models;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fiber;Frustration;Functional disorder;Glucose;glycation;Goals;Grain;Health;Heterogeneity;Human;Hydration status;Impairment;insight;Intervention;Investigation;Kinetics;Knowledge;Length;life span;Link;Location;Lung;Mass Spectrum Analysis;mechanical drive;Mechanics;Methods;Modeling;Modification;Molecular;molecular modeling;molecular scale;molecular site;monomer;multi-scale modeling;multiphoton microscopy;Mutation;Nature;network architecture;network models;optical imaging;Organ;Pathologic;Polymers;polypeptide;Polysaccharides;Post-Translational Protein Processing;Process;Property;Proteins;Reproducibility;Research;Resolution;Roentgen Rays;Role;Shapes;single molecule;Site;Skin;Spectrum Analysis;stressor;Stretching;Structural Protein;Structure;Testing;Thermodynamics;Tissues;translational impact;Tropoelastin;Vertebrates;Viscera;Water;Work

PROJECT_TITLE: Multiscale Effects of Aging on Elastic Arterial Tissue Mechanics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The real-world evidence generated by this project will identify which medication therapies maximize benefits and safety for pregnant people with chronic hypertension, including those with high-risk comorbidities. This evidence will be highly informative for treatment of chronic hypertension in pregnancy, which is an urgent public health need. Thus, the proposed project aligns with the mission of NHLBI to promote the prevention and treatment of heart, lung, and blood disorders so individuals can live longer and more fulfilling lives.

PI_NAMEs: LEONARD, STEPHANIE A. (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Abruptio Placentae;Address;Adherence;adherence rate;adverse outcome;Affect;American College of Obstetricians and Gynecologists;antenatal;Anti-Hypertensive Agents;Birth;Blood Pressure;Cardiovascular Diseases;cardiovascular health;Chronic;Chronic Kidney Failure;clinical care;comorbidity;congenital anomaly;Diabetes Mellitus;Discipline of obstetrics;distributed data;Dose;effective therapy;Effectiveness;Electronic Health Record;Equity;fetal;Fetal Death;Fetal Growth Retardation;Fetus;Goals;Health;Heart Diseases;Hematological Disease;high risk;Hypertension;hypertension treatment;improved;Individual;Infant;innovation;Knowledge;Low Birth Weight Infant;Lung Diseases;Maternal Health;maternal morbidity;maternal risk;Maternal-fetal medicine;Medical;Medical Informatics;Mentorship;Methods;Mission;Morbid Obesity;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;neonatal health;neonatal morbidity;Neonatal Mortality;neonatal outcome;obstetric outcomes;optimal treatments;Outcome;Perinatal;Perinatal Epidemiology;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnant;Premature Birth;prevent;Prevention;programs;Public Health;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Project Grants;Risk;Safety;severe maternal morbidity;Small for Gestational Age Infant;Societies;Testing;Training;treatment disparity;treatment optimization;Universities;Work

PROJECT_TITLE: Optimizing treatment of chronic hypertension in pregnancy using a national distributed data network

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Orphan Drug;Patient Safety;Radiation Oncology;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Study Description Patients with oropharyngeal squamous cell carcinoma who have an AJCC 8th edition stage of T0-T4, N0-N3, M0 will be enrolled on our double-blind, randomized clinical trial assessing the efficacy of MRI sialography guided parotid ductal sparing. Patient reported xerostomia and saliva mass will be compared between groups at 6 and 12 months post-treatment. Atlas-based duct segmentation analyses will be conducted to potentially facilitate broader implementation.

PI_NAMEs: FRIED, DAVID V (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Address;Adopted;Aftercare;American Joint Committee on Cancer;Anatomy;Atlases;Candida;Categories;chemoradiation;Clinical;cohort;Contralateral;Data;Deglutition;Dental;Dental caries;design;Dose;Dose Limiting;Double-Blind Method;Double-blind trial;Duct (organ) structure;Effectiveness;efficacy evaluation;Enrollment;experience;Goals;Head and Neck Cancer;Human Papillomavirus;Image;improved;improved outcome;Injury;insight;Intervention;Location;Magnetic Resonance Imaging;malignant oropharynx neoplasm;Mastication;Methodology;Methods;Morbidity - disease rate;Natural regeneration;novel;oral infection;Oropharyngeal Neoplasms;Oropharyngeal Squamous Cell Carcinoma;Output;Parotid Gland;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Periodontal Diseases;Phase;phase II trial;Pilot Projects;preservation;prevent;primary endpoint;prospective;Quality of life;Radiation;Radiation therapy;Randomized;randomized, clinical trials;Regimen;Reporting;Risk;Saliva;Salivary;Salivary duct structure;Salivary Glands;Sialography;side effect;standard of care;stem cell function;stem cells;Stensen's duct;Structure;symptomatic improvement;Symptoms;Taste Perception;Techniques;Therapeutic;Time;Toxic effect;tumor;Use Effectiveness;Viscosity;X-Ray Computed Tomography;Xerostomia

PROJECT_TITLE: A Phase II Randomized Assessment of Sparing Parotid Ducts via MRI Sialography for Reduced Patient Reported Xerostomia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (03)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE This project aims to understand how heart tissues differentiate during human development by studying a 3D, in vitro, temporally dynamic differentiation system that faithfully recapitulates fetal differentiation patterns of the heart. We will carry out aims that span efforts toward mapping, perturbing, modeling, and validating our model- based understanding of these data, with a goal of learning DNA sequence elements that drive gene expression programs during development. These efforts will enable us to identify specific genetic determinants of developmental heart defects.

PI_NAMEs: GREENLEAF, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;antibody test;ATAC-seq;Atlases;Automobile Driving;Binding;Binding Sites;Biological Assay;Biological Models;Cardiac;Cardiac Myocytes;cardiogenesis;cell fate specification;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;combinatorial;Complex;computational network modeling;Computer Models;Congenital Heart Defects;CRISPR/Cas technology;Data;Data Collection;Data Set;data standards;de novo mutation;deep learning;deep neural network;Development;Developmental Process;Disease;DNA;DNA Sequence;DNA-Directed RNA Polymerase;dosage;Elements;Endothelial Cells;Endothelium;Enhancers;fetal;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Determinism;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Heart;heart defect;Heart Diseases;heart function;Human;Human Development;human disease;human induced pluripotent stem cells;human pluripotent stem cell;In Vitro;Individual;induced pluripotent stem cell;Joints;knock-down;Learning;Link;Maps;Measures;Medical;method development;Methods;Modeling;Molecular;molecular phenotype;Multiomic Data;multiple omics;Mutation;network models;Neural Crest;neural network;Neural Network Simulation;Nucleic Acid Regulatory Sequences;Nucleotides;Organoids;Output;Patients;Pattern;Phenotype;Polymerase;predictive modeling;Process;programs;Property;Proteins;Recording of previous events;Regulation;Regulatory Element;Research Personnel;RNA;scaffold;single cell ATAC-seq;Sorting;syntax;System;Testing;Time;Tissue Differentiation;Tissues;Training;training data;Trans-Activators;transcription factor;Transcription Factor 3;transcriptome sequencing;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Defining and perturbing gene regulatory dynamics in the developing human heart to understand mechanisms of congenital heart defects

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Cytokines govern key cellular processes of pregnancy. We recently discovered that the cytokine Interleukin 27 (IL-27) is a critical player of immunity at the maternal-fetal interface, and here, we propose to define the mechanistic features of IL-27 signaling that underlie its protective capacity during congenital infection. Outcomes from our work will provide new fundamental insights into immune regulatory cytokine communication and function at the maternal-fetal interface with an overarching goal to improve neonatal outcomes.

PI_NAMEs: JURADO, KELLIE ANN (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Anti-Inflammatory Agents;Anti-viral Response;Cell Physiology;Cells;cellular targeting;Communication;congenital infection;congenital ZIKV infection;Cues;cytokine;Cytokine Network Pathway;Data;fetal;Fetal Development;Functional disorder;Genetic Transcription;Goals;Homeostasis;Human;Immune;Immune response;Immunity;Immunobiology;Immunologics;immunoregulation;improved;Infection;Inflammation;Inflammatory;insight;Interleukins;Investigation;Knowledge;Literature;Lymphocyte;Maternal Health;maternal outcome;Maternal-Fetal Exchange;Mediating;Molecular;mouse model;Mus;neonatal outcome;Organoids;Outcome;pathogen;Pathology;Placenta;placental trophoblasts;Pregnancy;prevent;Production;Property;Regulatory T-Lymphocyte;Reproduction;Reproductive Biology;Research;Role;Signal Transduction;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;trophoblast;Viral;Viral Genes;Viral Load result;Viral Physiology;Virus Diseases;Work

PROJECT_TITLE: IL-27 is a protective cytokine during congenital infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Hematology;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative This proposal seeks to develop a new molecular strategy to limit neurovascular injury in blinding eye disease. ACAT1 (acyl-Coenzyme A: cholesterol acyltransferase 1) is a critical regulator/activator of cholesterol metabolism and a promotor of an inflammatory microglia/macrophage phenotype. The proposed studies are designed to use a highly specific ACAT1 inhibitor and ACAT1 deficient mice and cells to investigate the specific role of myeloid cell ACAT1 in ischemic retinopathies and to define the underlying mechanisms.

PI_NAMEs: CALDWELL, RUTH B (contact);ROJAS, MODESTO ANTONIO

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Abbreviations;Acyl Coenzyme A;Alzheimer's Disease;Amplifiers;angiogenesis;Angiogenic Factor;Area;Atherosclerosis;Biological Assay;Blindness;Blood capillaries;Blood donor;Blood specimen;Blood Vessels;Bone Marrow;Brain Hypoxia-Ischemia;Cell Proliferation;Cells;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Clinical Trials;clinically significant;Coculture Techniques;Data;design;diabetic;Diabetic mouse;Diabetic Retinopathy;Dyslipidemias;Early Intervention;effective therapy;Endothelial Cells;Enzymes;Esterification;Exposure to;Eye diseases;Functional disorder;Goals;Hypoxia;immune activation;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;inhibitor;Injury;Intestines;Ischemia;Knock-out;Knockout Mice;LDL Cholesterol Lipoproteins;Leukostasis;lipid disorder;Lipids;Liver;Low Density Lipoprotein Receptor;LoxP-flanked allele;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Microglia;migration;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;neurovascular;neurovascular injury;new therapeutic target;normoxia;novel strategies;overexpression;Oxidative Stress;oxidized low density lipoprotein;Oxygen;Pathologic;Pathology;Patients;Phenotype;Play;Premature Infant;prevent;Prevention;promoter;Protein Isoforms;Proteins;receptor;receptor expression;repaired;Retina;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Role;Signal Transduction;Sterol O-Acyltransferase;sterol O-acyltransferase 1;sterol O-acyltransferase 2;Sterols;Streptozocin;Stress;targeted treatment;Testing;Tissues;TNF gene;Transferase;Up-Regulation;uptake;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Permeabilities;visual dysfunction

PROJECT_TITLE: Myeloid ACAT1 in ischemic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Public Health Statement Autoimmune diseases pose a major challenge to global health. The goal of the current proposal is to understand the molecular mechanisms of FoxP3, one of the genetic factors causing a multi-organ autoimmune syndrome, IPEX. Detailed molecular mechanisms of FoxP3 could provide insights into therapeutic strategies.

PI_NAMEs: HUR, SUN  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Affect;Architecture;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;Biochemical;Biochemistry;Biological Assay;Cells;Cellular Immunology;ChIP-seq;Chromatin;Chromatin Loop;cofactor;Complex;Consensus Sequence;Cryoelectron Microscopy;Data;Data Analyses;dimer;Dimerization;DNA;DNA Binding;DNA Binding Domain;ds-DNA;Family;FOXP3 gene;Gene Expression;Gene Expression Regulation;Genetic;genetic element;Genetic Transcription;Genome;Genomic approach;genomic locus;Genomics;global health;Goals;Homeostasis;Immune;Immune system;Immunity;Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome;Impairment;improved;Inflammation;Inflammatory;insight;Lead;Length;Link;loss of function mutation;Maintenance;Mediating;Microsatellite Repeats;Modeling;Molecular;Molecular Conformation;monomer;Morphologic artifacts;Mutation;novel;Organ;Pathogenicity;Plasmids;Play;Preparation;prevent;Proteomics;Public Health;reconstitution;recruit;Regulatory T-Lymphocyte;Reporter;Reporting;Research;Resolution;Role;Sampling;scaffold;Signal Transduction;Specificity;stem;structural biology;Structure;Syndrome;System;T cell differentiation;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;transcription factor;Transcriptional Regulation;Validation;Work

PROJECT_TITLE: Mechanism of the transcription factor FoxP3 in regulatory T cell development

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: PROJECT NARRATIVE  Surveillance for cancer incidence and mortality is crucial to cancer control and to cancer research, but measuring cancer registry completeness is extremely challenging. Current measures leave out the two most common cancers, as well as less common cancers, and universally include data only from Black people and White people, therefore routinely misestimating completeness for registries covering populations with high proportions of Asian people, Native American people, and people of Hispanic ethnicity. We propose a new comprehensive method to improve the rigor and reproducibility of measurement of completeness for US cancer registries and to guide choices of where registries can invest resources to optimize overall and group- specific completeness going forward.

PI_NAMEs: LASH, TIMOTHY L. (contact)

PROGRAM_OFFICER_NAME: LEWIS, DENISE

PROJECT_TERMS: access disparities;Address;Age;American;anti-cancer research;Asian population;Behavioral;Black Populations;Breast;Calendar;Cancer Control;Cancer Detection;cancer health disparity;cancer site;Catchment Area;Categories;Certification;Characteristics;Code;computing resources;County;COVID-19 pandemic;Data;data registry;Data Sources;design;Disparity;Ethnic Origin;Federal Government;Funding Agency;Future;Genetic Predisposition to Disease;Geographic Locations;Geography;Goals;Health Resources;Health Services Accessibility;Hispanic Populations;improved;Incidence;Individual;Intervention;Intuition;Investments;Joints;Link;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Native American population;neoplasm registry;Outcome;Output;pandemic disease;pandemic disruption;Persons;Policies;Population;Prevention;Prostate;Public Health;Quality of Care;Race;rare cancer;Registries;Reporting;repository;Reproducibility;Research;Research Project Grants;Resources;Risk Factors;Rural;screening;sex;surveillance data;Time;Time trend;tool;trend;Update;user-friendly

PROJECT_TITLE: Improving measurement of cancer registry completeness

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

PHR: We propose a randomized controlled trial of a self-management support intervention for low-income, minority adults with COPD that involves comprehensive screening for and targeted management of barriers to COPD control and combines this with home-based pulmonary rehabilitation and pre-emptive medication prescribing for COPD exacerbations. We will compare the intervention with an attention control for effects on COPD controller medication adherence and other self-management behaviors, symptoms and exercise capacity at 6 months and hospitalizations and emergency department visits at 12 months.

PI_NAMEs: FEDERMAN, ALEX D (contact);WISNIVESKY, JUAN P

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accelerometer;acute care;Address;Adherence;Adult;Adult asthma;Affect;Age;Aging;Antibiotics;Asthma;asthma model;asthmatic patient;Attention;attentional control;Behavior;Behavior Control;Belief;Benchmarking;Black Populations;Black race;Caring;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic obstructive pulmonary disease education;Clinical;Cognitive;Community Health Aides;comparison intervention;cost;Couples;Data;Death Rate;design;disease model;disorder control;Drug Prescriptions;Early Intervention;Educational Materials;Emergency department visit;Emergency Situation;Equity;ethnic minority;evidence base;Exercise;exercise capacity;Exercise Tolerance;Face;feasibility testing;feasibility trial;Funding;Goals;Guidelines;Health;Health behavior;health belief;health care model;health equity;health inequalities;Healthcare;Heterogeneity;Home;Hospital Mortality;Hospitalization;improved;Individual;Inhalation;Inhalators;inner city;innovation;Intervention;intervention effect;Latinx;Latinx population;Low income;Low Income Population;Measures;Mediating;Medical;medication compliance;Minority;Minority Groups;minority patient;Modeling;Morbidity - disease rate;National Heart, Lung, and Blood Institute;New York City;older adult;Outcome;Outcome Assessment;Outpatients;Participant;patient oriented;Patients;people of color;Persons;Pharmaceutical Preparations;Physical activity;physical impairment;preference;Preparation;primary outcome;programs;Protocols documentation;psychosocial;pulmonary rehabilitation;Quality of life;Questionnaires;racial minority;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;reduce symptoms;Remote session;Role;screening;secondary analysis;Self Care;Self Management;self-management program;Smoke;socioeconomics;Steroids;Structure;success;Symptoms;Techniques;Testing;theories;Training and Education;treatment effect;Walking

PROJECT_TITLE: Comprehensive Patient-centered Home-based care coaching for COPD self-management

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Gene Therapy;Genetics;Human Genome;Liver Disease;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE This proposal aims to understand how regulatory DNA sequences quantitatively tune gene expression in specific cell types and/or disease contexts, and how we can engineer these sequences to reprogram gene expression to restore function in the context of Alagille Syndrome. Our approach combines reading and writing of the genome in human pluripotent stem cells that can be used to model the functions of cells from human blood vessels. Our study will lay the foundations for future studies to develop CRISPR therapeutics for Alagille Syndrome and other diseases.

PI_NAMEs: ENGREITZ, JESSE M (contact);RABINOVITCH, MARLENE

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Affect;Alagille Syndrome;Alleles;Biliary Atresia;Binding Sites;Blood Vessels;Cell Physiology;cell type;Cells;Chromatin;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Computer Models;Congenital Heart Defects;CRISPR screen;CRISPR therapeutics;Defect;design;Disease;Distal;DNA;DNA Sequence;dosage;Elements;Endothelial Cells;Engineering;Enhancers;experimental study;Exposure to;Fluorescent in Situ Hybridization;Foundations;functional restoration;Future;gene correction;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene therapy;Genes;Genetic Transcription;Genome;genome editing;genome-wide;high throughput screening;Human;Human Genome;human induced pluripotent stem cells;human pluripotent stem cell;innovation;invention;Knowledge;Life;loss of function mutation;Loss of Heterozygosity;Lung;Maps;Modeling;Molecular;Multiomic Data;Mutate;Mutation;novel therapeutic intervention;Nucleotides;Outcome;Pathologic;Patients;Phenotype;Physiological;prime editing;Production;programs;promoter;Rare Diseases;Reading;Regulatory Element;repaired;Resolution;restoration;RNA;shear stress;Side;Smooth Muscle Myocytes;Sorting;Technology;Testing;Therapeutic;tool;transcription factor;Variant;Vascular Endothelial Cell;Writing

PROJECT_TITLE: Mapping, programming, and correcting gene regulatory sequences for Alagille Syndrome

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]