NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Precision Medicine;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: VONA ONCOLOGY, LLC

ORG_STATE: CO

PHR: PROJECT NARRATIVE Triple-negative breast cancer is the most aggressive of the major sub-types of breast cancer and is  overrepresented in young women and black women. The present proposal seeks to bring a novel therapeutic  agent, VDX-111, to a stage sufficiently mature to seek IND approval and to attract the investment required to  initiate human trials. Whether VDX-111 proves efficacious as a stand-alone therapy for triple-negative breast  cancer or improves outcome in combination with standard of care chemotherapy, the proposed project directly  impacts the mission of NIH to develop new therapies that will improve the capability to treat and/or prevent  disease.

PI_NAMEs: LAMBERT, CHERIE  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Active Sites;Acute;Address;Antineoplastic Agents;Apoptotic;Applications Grants;Binding;Biological Assay;black women;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Canis familiaris;cell killing;cell motility;Cell Proliferation;Cells;chemotherapeutic agent;chemotherapy;Clinic;Clinical;clinical development;Clinical Trials;clinically significant;combinatorial;Combined Modality Therapy;commercialization;Data;Databases;design;detection method;Development;Diagnosis;Disease;disorder subtype;Documentation;Dose;Doxorubicin;Drug Combinations;drug development;Drug resistance;Drug Targeting;empowerment;experience;functional genomics;Genes;genome-wide;Goals;Growth;high risk;Human;Impairment;improved;improved outcome;in silico;In Vitro;in vitro activity;in vivo;Induction of Apoptosis;insight;Invaded;Investments;knock-down;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Methods;Mission;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;Outcome Study;Paclitaxel;Patient Care;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;phase 1 study;phase 2 study;Phosphoric Monoester Hydrolases;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;predictive marker;prevent;Publishing;Rattus;relapse risk;Research;research clinical testing;resistance mechanism;response biomarker;Risk-Benefit Assessment;Route;Safety;Scientist;Serum;side effect;Small Business Innovation Research Grant;small hairpin RNA;Specificity;standard of care;Survival Rate;synergism;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;therapy resistant;timeline;Tissues;Toxic effect;Translating;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor xenograft;United States National Institutes of Health;Validation;Xenograft procedure;young woman

PROJECT_TITLE: VDX-111: A novel targeted therapeutic for triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-T(10)B]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative I will develop a paradigm-shifting molecular genetic technology for identifying and manipulating cell types across organ tissues and animal species that is specific, easy, affordable, programmable, and general. This new technology has the potential to transform the scale and rate of discovery across biomedical fields, with clinical and industrial applications and sweeping impacts on human health.

PI_NAMEs: HUANG, Z JOSH (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Ablation;Anatomy;Animals;Base Pairing;Biological Process;Biology;Biomedical Research;Biotechnology;Birds;Brain;Cell Culture System;Cell Physiology;cell type;Cells;Cerebral cortex;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;cost;design;Devices;Disease;DNA;dsRNA adenosine deaminase;Engineering;Enhancers;Enzymes;Ethical Issues;Genes;genetic manipulation;genetic technology;Genetic Transcription;Genome;Germ Lines;Health;Human;Industrialization;Link;Macaca;Medicine;Methods;Molecular Genetics;Monitor;Mus;Neurons;new technology;next generation;novel strategies;Organ;Organism;Physiological;Population;Primates;Ribonucleoproteins;RNA;RNA Editing;RNA library;Role;sensor;Somatic Cell;Specimen;System;Technology;Tissue Engineering;Tissues;transcriptomic profiling;Validation;Visualization

PROJECT_TITLE: RNA-programmable cell-type targeting, editing, and therapy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Methamphetamine use significantly impairs sleep, which in turn may predispose relapse to methamphetamine taking, leading to a vicious cycle of drug-induced sleep impairment, relapse, and addiction. This research project will identify potential mechanisms of sleep disruption induced by methamphetamine abuse by investigating a specific brain system: the orexin/hypocretin system. The results of these studies may lead to new and more broadly effective medications that will target both methamphetamine abuse and related insomnia.

PI_NAMEs: BERRO, LAIS F (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: actigraphy;addiction;Affect;Animals;antagonist;behavior observation;Behavioral;Brain;Chronic;Cues;Development;Disease;Dose;Drug Addiction;effective therapy;Electroencephalography;Electromyography;Electrooculography;Female;High Prevalence;high risk;Human;hypocretin;Impairment;Implant;Individual;innovation;Link;Macaca mulatta;male;Mediating;METH abuser;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;methamphetamine effect;methamphetamine use;Modeling;Monkeys;neurobiological mechanism;novel;orexin 1 receptor;orexin B receptor;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Play;Polysomnography;Primates;Process;prospective;Public Health;receptor;Recording of previous events;Relapse;REM Sleep;Reporting;Research;Research Project Grants;Role;sedative;Self Administration;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Sleeplessness;Stimulant;stimulant abuse;stimulant dependence;stimulant use disorder;System;Telemetry;Testing;Time;tool;Work

PROJECT_TITLE: Role of orexin receptors in the abuse- and sleep-related effects of methamphetamine


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This proposed research is relevant to public health because defining the regulatory role of CHI3L1 for neuroinflammation in health and in disease not only greatly advance our knowledge on the non-neuronal contributions to the pathogenesis of Alzheimer’s disease (AD) but also present a proof of principle for forthcoming translational studies focusing on neuroinflammation underlying neurodegeneration. Developing strategies which target neuroinflammation to improve clinical outcome and alleviate disease impact are important as they are broadly applicable to a wide range of neurodegenerative disorders in addition to AD. Thus, this proposed research is relevant to the part of NIH’s mission that pertains to reducing the burdens of human disability.

PI_NAMEs: HUANG, YU-WEN ALVIN  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloidosis;Anti-Inflammatory Agents;Astrocytes;Behavioral;Behavioral Paradigm;Binding;Biological;Brain;brain cell;Brain Pathology;Cell Physiology;Cell Surface Receptors;cell type;CHI3L1 gene;Chitinase;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;Crossbreeding;Data;Defect;Dementia;Development;disability;Disease;early detection biomarkers;Elements;familial Alzheimer disease;Funding;glial activation;Gliosis;Goals;Health;Histopathology;Human;human stem cells;Immunity;improved;In Vitro;in vivo;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;inhibitor;Injections;injury and repair;innovation;Knock-out;Knowledge;Laboratories;Lentivirus;LoxP-flanked allele;Mediating;Methods;Microglia;Mission;Molecular;mouse model;Mouse Strains;Mus;mutant;Mutation;Nerve Degeneration;nerve stem cell;neural;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron apoptosis;neuron loss;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;neuroprotection;neurotoxic;neurotoxicity;NF-kappa B;novel;Outcome;Outcome Study;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peripheral;Population;presenilin-1;prevent;Process;Proteins;Public Health;Publishing;receptor;receptor for advanced glycation endproducts;Research;response;Role;Signal Transduction;Signaling Molecule;small hairpin RNA;Standardization;Stress;System;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Transgenic Mice;Transgenic Organisms;translational potential;translational study;United States National Institutes of Health;Work

PROJECT_TITLE: Elucidating the role of CHI3L1/YKL-40 in Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative (Public Health Relevance) Improved diagnostic tests for early detection of Alzheimer’s disease (AD) are urgently required if therapies to delay or prevent progression in our increasingly aging population are to be developed. This project aims to develop a new diagnostic blood test for AD based on detection of a novel chemical structure, that develops over time in brain amyloid and is neurotoxic. This diagnostic test based on the identification of a new target is expected to significantly improve the specificity of current AD diagnostic testing.

PI_NAMEs: SCHEY, KEVIN L (contact);TRUSCOTT, ROGER J

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta oligomer;Age;age related;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease test;Alzheimer’s disease biomarker;American;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid deposition;Applications Grants;Autopsy;Biological Assay;Biological Markers;Blood;Brain;Central Nervous System;Cerebrospinal Fluid;Cerebrum;Characteristics;Chemical Structure;Chemistry;Clinical;cognitive function;Collaborations;crosslink;Data;Dementia;Detection;Development;Diagnosis;diagnostic strategy;Diagnostic tests;diagnostic tool;dimer;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Epidemic;extracellular;Funding;Future;Healthcare;Human;improved;interest;Knowledge;Laboratories;Link;manufacture;Measurement;Mediating;Modification;Monitor;Monoclonal Antibodies;monomer;Nervous System Trauma;Neurodegenerative Disorders;neurotoxic;novel;novel diagnostics;novel strategies;Pathology;Peptides;Peripheral;Physiological;Plasma;Positron-Emission Tomography;prevent;Preventive measure;protein crosslink;Proteins;public health relevance;response;Sampling;Senile Plaques;Sensitivity and Specificity;Serum;Skeletal Muscle;skills;Specificity;stem;Structure;Surrogate Endpoint;Talents;tau-1;Techniques;Time;Tissues;Toxic Actions;treatment trial;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: A new diagnostic test for AD based on a neurotoxic Abeta Dimer

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: CHARLESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This project will identify epigenetic mechanisms that result in the observed downregulation of KLF4 in scleroderma lung fibroblasts. A better understanding of these regulatory mechanisms will allow us to design effective therapeutic strategies to restore normal KLF4 levels and ameliorate fibrosis.

PI_NAMEs: RENAUD, LUDIVINE  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Advisory Committees;Affect;authority;Binding;bioinformatics tool;Biology;career;Cause of Death;cell type;chromatin immunoprecipitation;COL1A1 gene;Complex;computerized tools;Connective Tissue Diseases;connective tissue growth factor;Data;design;differential expression;Down-Regulation;effective therapy;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;Extramural Activities;Fibroblasts;Fibronectins;Fibrosis;Gastrointestinal tract structure;gene repression;Genes;GKLF protein;Goals;Heart;Heart Diseases;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;insight;Institution;interest;Interstitial Lung Diseases;Kidney;Kruppel-like transcription factors;Lead;loss of function;Lung;Malignant neoplasm of lung;Medical;Medicine;Mentors;Mentorship;Messenger RNA;MicroRNAs;Molecular;Network-based;novel;Nucleic Acid Regulatory Sequences;Organ Culture Techniques;overexpression;Pathway interactions;Patients;Phase;Play;pre-clinical;prevent;programs;promoter;Property;Protein Isoforms;Proteins;Pulmonary Fibrosis;Regulation;Repression;Research;Research Personnel;Rheumatology;Role;Scleroderma;single cell analysis;single-cell RNA sequencing;Skin;skin fibrosis;Small Interfering RNA;Small RNA;South Carolina;Structure of parenchyma of lung;Systemic Scleroderma;Testing;Therapeutic;therapeutic miRNA;therapeutically effective;Training;transcription factor;transcriptome sequencing;translational scientist;Universities;Untranslated RNA;vascular abnormality;Work

PROJECT_TITLE: Epigenetic Regulation of KLF4 in SSc-associated lung fibrosis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: PROJECT NARRATIVE A substantial number of low-income older adults are frequently exposed to a hot home ambient temperature, either because they cannot afford air conditioning, or they do not possess sufficient motor and/or cognitive ability to properly use it. The proposed research aims to understand the impact of the summertime variations in home thermal environment on health and wellbeing of low-income community-dwelling older adults. In the face of a rapidly changing climate, this is an urgently-need line of research that is expected to inform public health policy and lead to development of clinical and environmental interventions that are tuned unique needs of each older adult living within their built environment.

PI_NAMEs: BANIASSADI, AMIR  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Affect;age effect;age related;Aging;aging related;Air Conditioning;Area;Award;Beds;biological sex;Boston;built environment;Cardiovascular Physiology;career;career development;catalyst;Center for Translational Science Activities;climate change;Clinical;clinical development;clinical translation;cognitive ability;cognitive function;cohort;Communities;Counseling;Development;Development Plans;Disparity;Engineering;Environment;Environmental Engineering technology;environmental intervention;Environmental Risk Factor;experience;Exposure to;Faculty;Foundations;frailty;Funding;Gait;Gerontology;Goals;Grant;Health;health assessment;health disparity;health management;Health Policy;Healthcare;Home;Home environment;Housing;Humidity;Impairment;Individual;Individual Differences;Infrastructure;interest;Intervention;Knowledge;Lead;Leadership;Liquid substance;Literature;Low income;Measurement;Measures;Medical Libraries;medical schools;Modeling;Monitor;Moods;Motor;older adult;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Periodicals;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physical Function;Physiologic Thermoregulation;Physiological;Physiology;Play;Polysomnography;Population;primary outcome;programs;Public Health;Questionnaires;Reaction Time;recruit;Regulation;Reporting;Research;Resources;Role;Running;Science;sensor;Series;sex;skills;Sleep;smartphone application;smartphone based assessment;Socioeconomic Status;Solid;Standardization;Statistical Data Interpretation;System;Technology;Temperature;Testing;Time;United States National Institutes of Health;Variant;Vulnerable Populations;Walking;wearable device;Weather;Writing

PROJECT_TITLE: The Effect of the Home Environment on Health and Wellbeing of Low-income Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Precision Medicine;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE  Herpesviruses including herpes simplex virus 1 (HSV-1) have been associated with risk for Alzheimer’s Disease (AD) and our proposal aims to systematically dissect the role of donor genetics (e.g. APOE e3 or e4 alleles) on human host genes and gene networks perturbed by HSV-1 in human cerebral organoids and human post-mortem brains. We aim to identify cell type specific AD-associated genes, networks and co- localization, as well as AD neuropathologies (secreted Ab42/40/38 and intracellular Ab42 and phosphorylated Tau-Thr212) and identify AD patient subtypes who may benefit from early anti-herpetic drug treatment for their AD pathologies. We propose 3 complementary aims that utilize novel technology and data integration methods development with RNA sequencing, spatial single-cell RNA sequencing, flow cytometry and human induced pluripotent stem cell derived cerebral organoids.

PI_NAMEs: LIM, TENG-TING ELAINE (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acyclovir;Address;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Amyloidosis;Antibodies;Antigens;apolipoprotein E-4;Astrocytes;Autopsy;Biological Assay;Brain;Cell Line;cell type;Cells;Cerebrospinal Fluid;Cerebrum;Clinical;Collaborations;Coupled;Data;data integration;Data Set;differential expression;Disease Outcome;Disease Progression;disorder subtype;Dose;Enzyme-Linked Immunosorbent Assay;epidemiology study;Etiology;experimental study;Flow Cytometry;Foundations;gene network;Genes;Genetic;Glial Fibrillary Acidic Protein;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;HHV-6A;Human;human data;Human Herpesvirus 7;human induced pluripotent stem cells;In Vitro;induced pluripotent stem cell;Infection;insight;large scale data;Late Onset Alzheimer Disease;method development;Methods;Microglia;Modeling;Molecular;Neurons;neuropathology;neurotropic virus;new technology;novel;oligodendrocyte progenitor;Organoids;Paper;pathogen;Pathogenesis;Pathway interactions;patient subsets;Pharmacotherapy;Population;pre-clinical;precision medicine;Prevalence;Process;Publishing;Reporting;Research;research and development;Resources;RNA Sequences;Role;Sampling;Seminal;single-cell RNA sequencing;stem cell model;tau-1;Technology;transcriptome sequencing;transcriptomics;Viral Load result

PROJECT_TITLE: Transcriptomics-based identification of cell type specific host genes and gene networks perturbed by HSV-1 in cerebral organoids.

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Endocrine Disruptors;Liver Disease;Nutrition

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Americans are exposed daily to per- and polyfluoroalkyl substances (PFAS) in their drinking water, food and air. PFAS cause adverse birth outcomes, suppress vaccine responses, and induce metabolic disease in people, although how this happens is unknown. We propose to determine how PFAS cause adverse health effects, focusing on metabolic disease in humans, by developing tools that focus on essential molecular regulators of lipids, the nuclear receptors PPARα, CAR and PXR.

PI_NAMEs: SCHLEZINGER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Address;adverse birth outcomes;Adverse effects;Agonist;Air;American;American diet;Backcrossings;Biochemical;Body Burden;Carboxylic Acids;cardiovascular disorder risk;Chemicals;Cholesterol;Cholesterol Homeostasis;clinically relevant;constitutive androstane receptor;consumer product;Cosmetics;Country;Data;density;Diet;dietary;Disease;Dose;drinking water;Dyslipidemias;Eating;Enterocytes;epidemiology study;Equilibrium;Exposure to;fatty acid oxidation;Fatty Liver;Female;Fibrates;Food;Genetic;Health;Hepatic;Hepatocyte;Homeostasis;Human;Hyperlipidemia;in vitro Model;in vivo;in vivo Model;Indoor environment;Industrial Product;insight;Intervention;Intestines;knock-down;LDL Cholesterol Lipoproteins;Link;lipid biosynthesis;Lipids;lipoprotein cholesterol;Liver;Liver diseases;liver injury;Maintenance;male;Metabolic Diseases;Modeling;Molecular;mouse model;Mus;National Health and Nutrition Examination Survey;non-alcoholic fatty liver disease;novel;Nuclear Receptors;Organ;outcome disparities;Pathology;perfluorooctane sulfonate;perfluorooctanoic acid;Persons;Pharmaceutical Preparations;Poly-fluoroalkyl substances;PPAR alpha;pregnane X receptor;Prevalence;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Research;response;Rodent;Serum;sex;species difference;Stress;Structure;Sulfonic Acids;Testing;tool;Toxicology;transcriptomics;Update;vaccine response

PROJECT_TITLE: Optimizing a human relevant mouse model to study adverse health effects of PFAS

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The inherent spatial and chemical complexity of the brain, particularly one affected by Alzheimer’s Disease, requires the development and application of multidimensional and multimodal imaging methods for the construction of comprehensive cellular atlases. Atlases from both healthy and AD human brains will relate metabolic species such as lipids, signaling molecules, and metabolic precursors to their structural framework in healthy and diseased brains. In brief, this project includes exploring the small molecule and lipid molecular changes associated with plaque formation and perturbation in context of cellular neighborhoods, and integration of mass spectrometry imaging and multiplexed immunofluorescence.

PI_NAMEs: NEUMANN, ELIZABETH KATHLEEN (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Architecture;Astrocytes;Atlases;Brain;Brain Diseases;brain health;Brain region;brain tissue;Catalogs;Cell Communication;cell type;Cells;Chemicals;Classification;Clinical Trials;Cognition;cohort;Communication;Complex;Data;data integration;Data Set;Development;Dimensions;Disease;Dissociation;experimental study;Failure;Fluorescence Microscopy;Gender;Genetic Heterogeneity;Goals;Heterogeneity;Hippocampus;Human;human disease;imaging modality;Immunofluorescence Immunologic;Immunohistochemistry;Knowledge;Label;Learning;Lipids;Literature;Machine Learning;mass spectrometric imaging;Memory;Metabolic;Metabolism;metabolomics;Molecular;Molecular Profiling;multimodal data;Multimodal Imaging;multimodality;neighborhood association;Neighborhoods;Nerve Degeneration;Nervous System Physiology;Neuroglia;Neurologic Dysfunctions;Neurologic Symptoms;Neurons;Neurosciences;novel;novel strategies;Outcome;Pathology;Patients;Phenotype;Physiological Processes;Proteomics;Research;Resolution;response;Role;Sampling;Severities;sex;Signal Transduction;Signaling Molecule;small molecule;Spatial Distribution;spatial integration;spatial relationship;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stains;stem;Techniques;Therapeutic;therapeutic target;therapeutically effective;Tissue Extracts;Tissues;Treatment outcome

PROJECT_TITLE: Architecture of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Pediatric;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE In this R01, we seek to determine some of the earliest sex-dependent mechanisms associated with the impact of ADAD mutations in early life brain development, as well as its potential impact on other important outcomes, such us learning abilities, academic performance and educational attainment. We will study children (aged 7 to 16 years) from a Colombian large extended family with autosomal dominant Alzheimer’s disease. We will focus on studying developmental consequences around puberty in brain function and neuroendocrine function in this group by examining childhood cognitive abilities and history of neurodevelopmental disorders; sex-hormones and puberty stages; brain microstructure and composition; and organization of functional connections in the brain, using fMRI.

PI_NAMEs: QUIROZ, YAKEEL T. (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Age;aged;Aging;aging process;Alzheimer's Disease;Alzheimer's disease risk;Automobile Driving;autosomal dominant Alzheimer's disease;Axon;Biochemical Markers;Biological;Biological Assay;bone age;Brain;Cerebrum;Child;Childhood;Clinical;Cognition;Cognitive;cognitive ability;cognitive performance;cohort;Colombian;Dementia;dementia risk;density;Development;Disease;early onset;Education;Emotional;Estradiol;Exhibits;Extended Family;Family;Female;Foundations;Functional Magnetic Resonance Imaging;Future;Gender;General Population;Gonadal Steroid Hormones;Graph;high risk;Hormonal;Hormones;Image;indexing;Individual;Investigation;kindred;Late Onset Alzheimer Disease;learning ability;Life;Link;Magnetic Resonance Imaging;male;Measures;medial temporal lobe;Memory;Methods;Mutation;mutation carrier;Myelin;Neurites;Neurobiology;Neurodevelopmental Disorder;Neuropsychology;Neurosecretory Systems;novel;Outcome;Pathway Analysis;Pattern;Performance;Physical Examination;Predisposition;Premature Menopause;presenilin-1;Puberty;Recording of previous events;reproductive;Research;resilience;Resolution;Risk;Roentgen Rays;Role;sex;Sex Differences;Short-Term Memory;skeletal;Structure;Temporal Lobe;Testing;Testosterone;virtual;Water

PROJECT_TITLE: Examining sex-differences in puberty and brain development in carriers of autosomal dominant Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE NU-9 is identified as the first compound that reduces protein aggregation, improves stability and integrity of both mitochondria and endoplasmic reticulum, and that enhances cytoarchitectural stability as well as axon outgrowth and branching/arborization in upper motor neurons that degenerate due to misfolded SOD1 toxicity and TDP-43 pathology, two non-overlapping causes of neurodegeneration. These significant findings encouraged us to form a comprehensive, multi-PI team to further investigate the cellular, molecular, and mechanistic impact NU-9 would have on neurons that degenerate in Alzheimer’s disease (AD) and related dementias, such as frontotemporal degeneration (FTD). Upon completion, we will better understand the mode of action of NU-9, potentially generate more potent and effective derivatives, and determine the impact NU-9 has on AD and FTD, two complex diseases that share many of the common cellular problems NU-9 was reported to overcome in our parent R01 application.

PI_NAMEs: KLEIN, WILLIAM L;OZDINLER, PEMBE HANDE  (contact);SILVERMAN, RICHARD B

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta oligomer;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;analog;Animal Model;Animals;Apical;Architecture;Autopsy;Axon;Axonal Transport;Behavior;Binding;Biological Assay;Biological Models;Cell model;comparative;Complex;Cytoskeleton;Data;Defect;Dementia;Dendrites;design;Development;Diagnosis;Disease;drug discovery;effective therapy;efficacy evaluation;Endoplasmic Reticulum;Event;experimental study;FDA approved;Foundations;frontotemporal degeneration;Frontotemporal Dementia;Functional disorder;functional improvement;Generations;Grant;Health;healthy volunteer;Human;improved;In Vitro;in vivo Model;inhibitor;insight;Interruption;Investigation;Label;Laboratories;Licensing;Memory;Memory Loss;metabolomics;Mitochondria;Molecular;motor neuron degeneration;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuronal survival;Neurons;neuropathology;neuroprotection;novel;Outcome;Parents;Pathology;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phase I Clinical Trials;phenylmethylpyrazolone;Photoaffinity Labels;Population;prevent;Property;protein aggregation;Protein Inhibition;protein TDP-43;Proteins;Pyrazolones;Reporter;Reporting;Riluzole;Sampling;sex;superoxide dismutase 1;System;Testing;therapy development;Toxic effect;Toxicology;Translating;Treatment Efficacy;treatment response;treatment strategy;Upper Motor Neuron Disease

PROJECT_TITLE: Investigations of the protein aggregation inhibitor NU-9 and its derivatives: mode of action and impact on Alzheimer’s disease and related dementias


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

PHR: In the 300,000 patients who undergo lower extremity revascularization for disabling peripheral artery disease each year, revascularization typically improves, but does not eliminate, walking impairment from peripheral artery disease. This randomized clinical trial will test whether home- based walking exercise and whether nitrate-rich beetroot juice, two safe and accessible interventions, significantly increase the benefits of lower extremity revascularization for disabling peripheral artery disease. The goal of this randomized clinical trial is to improve walking performance after lower extremity revascularization for patients disabled by peripheral artery disease.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: angiogenesis;attentional control;beneficiary;Biological Availability;Biopsy;Blood capillaries;comparison control;density;design;disabled;Disabling;Dose;enzyme activity;Exercise;Failure;follow-up;Gait abnormality;Gastrocnemius Muscle;Goals;hemodynamics;Home;Hour;Human;Hyperplasia;improved;improved mobility;Inflammation;Intervention;intervention effect;Ischemia;Juice;Limb structure;Lower Extremity;Measures;Medicare;Mitochondria;Muscle;Muscle satellite cell;Nitrates;Nitric Oxide;Nitrites;Operative Surgical Procedures;Outcome;Patients;Perfusion;Peripheral arterial disease;Persons;Placebos;Plasma;Pre-Clinical Model;prevent;Procedures;Production;Questionnaires;Randomized;randomized, clinical trials;repaired;revascularization;Site;Skeletal Muscle;Skeletal Muscle Satellite Cells;Source;Testing;tetrahydrobiopterin;Thrombosis;Time;vascular smooth muscle cell migration;vasodilator-stimulated phosphoprotein;Walking;walking performance

PROJECT_TITLE: IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN ANTONIO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Vascular contributions to Alzheimer's disease and related dementias are recognized as important to understand and intervene in the complexity and disparities of dementia in older adults. Yet, most studies from Alzheimer's Disease Research Centers (ADRCs) do not measure cerebrovascular lesions because they require time- and labor-intensive methods. We propose to apply computerized novel "deep learning" methods to a consortium of studies from four ADRCs, and will explore the impact of cerebrovascular lesions on Alzheimer's disease biomarkers, cognitive impairment, and decline, establishing the value of new cerebrovascular measures for ADRC studies and yielding rich datasets for future analyses. iv

PI_NAMEs: HABES, MOHAMAD  (contact);HUGHES, TIMOTHY M.

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Adoption;age related;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anatomy;Area;Atrophic;Autopsy;Biological Markers;Blood;Blood Vessels;brain magnetic resonance imaging;California;cerebral microbleeds;Cerebral small vessel disease;cerebrovascular;cerebrovascular lesion;Cerebrum;Clinical;Clinical Research;Cognition;Cognitive;cohort;Cohort Studies;Communities;Computer software;computerized;Consumption;Data;Data Set;deep learning;deep learning model;Dementia;Development;Diabetes Mellitus;Diagnosis;Disease Marker;Disease Outcome;Disparity;Ethnic Origin;Exhibits;Funding;Future;Gender;Glial Fibrillary Acidic Protein;Goals;Grant;Health;Hippocampus;human error;Hypertension;IL6 gene;Image;imaging biomarker;imaging study;Impaired cognition;improved;indexing;Individual;Interleukin-10;Investments;Joints;Lead;Lesion;Link;machine learning model;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Manuals;Measures;Mediating;Metabolic;Metabolic Pathway;Methodology;Methods;Microvascular Dysfunction;Minority;Minority Groups;MRI Scans;Multi-Ethnic Study of Atherosclerosis;multimodality;neuroimaging;neuropathology;novel;novel marker;older adult;Outcome;Pathology;Pattern;Phenotype;Physiologic pulse;Prevention;Probability;Protocols documentation;Published Comment;Race;Reading;Recommendation;recruit;Registries;Reproducibility;Research;research study;Resolution;Resources;Role;Severity of illness;South Texas;Staging;Standardization;standardize measure;symposium;System;tau Proteins;tau-1;Techniques;Technology;Time;TNF gene;Training;TREM2 gene;Underrepresented Populations;United States National Institutes of Health;Universities;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular contributions;Vascular Diseases;vascular factor;White Matter Hyperintensity;Wisconsin;Work

PROJECT_TITLE: Vascular Imaging Biomarker Relationships to Alzheimer’s disease (VIBRA)


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Organ Transplantation;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE After heart transplantation, the vessels that supply blood to the heart can become diseased. Known as cardiac allograft vasculopathy (CAV), it is a form of heart rejection and a leading cause of death in these patients. Through this study, we aim to find new ways to detect CAV early, find new treatments to prevent this disease, and help heart transplant patients live longer and healthier lives.

PI_NAMEs: AMANCHERLA, KAUSHIK  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Academic Medical Centers;Address;Advisory Committees;Age;Animal Model;Architecture;ATAC-seq;Award;Bioinformatics;Biological Assay;Biological Markers;Biology;Biopsy;Biopsy Specimen;Blood;Cardiac;Cardiac Volume;career;career development;Cause of Death;cell type;Cells;Cessation of life;Chromatin;Chronic;Clinical;clinical care;clinical investigation;Collaborations;collaborative approach;Communication;Consent;Coronary;Coronary Angiography;Coronary artery;Data;detection method;Development;Development Plans;Diffuse;Disease;Endothelium;Ensure;Etiology;Event;Evolution;Exhibits;experience;Foundations;Freezing;Funding;Future;Gender;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Goals;graft failure;Graft Survival;Heart;heart allograft;Heart Diseases;Heart failure;Heart Transplantation;Histologic;Human;Immune;Immunologics;Immunology;improved;Individual;Inflammatory;Interdisciplinary Study;Ischemia;Knowledge;Lesion;Leukocytes;liquid biopsy;Machine Learning;Manuals;Mentors;Mentorship;Messenger RNA;Microvascular Dysfunction;molecular phenotype;mortality;mRNA Expression;multidimensional data;multiple omics;Myocardial;Myocardial tissue;novel strategies;Nuclear;Nuclear RNA;Obstruction;Pathogenesis;patient oriented;patient oriented research;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Physicians;Plasma;Positioning Attribute;post-transplant;prevent;Prevention;Process;programs;Progressive Disease;prospective;Prospective Studies;Publishing;recruit;Regulation;Research;Research Design;sample collection;Scientist;single nucleus RNA-sequencing;skills;Statistical Models;statistics;success;targeted treatment;Techniques;Time;Tissues;Training;transcriptome sequencing;Translational Research;transplant centers;Transplant Recipients;Transplantation Immunology;Trees;Vascular blood supply;Vascular Diseases;Work;Xenograft procedure

PROJECT_TITLE: Cell-Specific Transcriptional Programs in Cardiac Allograft Vasculopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (J1)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Data Science;Genetics;Human Genome;Lung;Pediatric;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Asthma is a common chronic disease characterized by substantial clinical heterogeneity, suggesting the existence of multiple asthma endotypes with distinct functional mechanisms. The overarching goal of this proposal is to utilize multi-omics data and innovative methodological approaches to disentangle asthma heterogeneity, identify endotypes, and investigate biological mechanisms underlying established risk factors. The results will identify novel biomarkers, create new asthma research hypotheses, and provide the foundation for targeted therapeutics and personalized care.

PI_NAMEs: HECKER, JULIAN ERIK (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Advisory Committees;antenatal;Asthma;asthmatic;Biological;Biological Markers;Biology;Birth;Blood;career;career development;Child;Childhood;Childhood Asthma;Chronic Disease;chronic respiratory disease;Clinical;Clinical Data;clinical heterogeneity;cohort;Collection;computerized data processing;Costa Rica;Data;data integration;data resource;Data Science;design;Development;Development Plans;Diagnosis;Disease;Doctor of Philosophy;Ensure;Environment;Environmental Exposure;epidemiologic data;Epidemiology;Epigenetic Process;Etiology;experience;Family;Fostering;Foundations;Functional disorder;Funding;Future;Genes;Genetic;genetic association;genetic epidemiology;Genetic Predisposition to Disease;Genetic Risk;genetic variant;genome sequencing;genome wide association study;genomic locus;Goals;Heterogeneity;high dimensionality;improved;innovation;Knowledge;Life;Link;Measurement;medical schools;Medicine;Mentors;metabolomics;Methodology;Methylation;Modeling;Modification;Molecular;multi-ethnic;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;novel marker;offspring;Outcome;Pathway interactions;Pattern;personalized care;Phenotype;phenotypic data;population stratification;Positioning Attribute;Process;programs;Protocols documentation;Recording of previous events;Research;respiratory;Respiratory Disease;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Scientist;Secure;Site;skills;Statistical Data Interpretation;statistics;Structure;success;targeted treatment;Techniques;Testing;tool;Training;Trans-Omics for Precision Medicine;transmission process;Umbilical Cord Blood;Variant;Vitamin D;whole genome

PROJECT_TITLE: Integrating multi-omics data to understand asthma heterogeneity and endotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE: The reason why specific neurons that are crucial to new memory formation die first and at early stages of Alzheimer’s disease is currently unknown, but excessive electrical activity is one of the earliest signs that they are dysfunctional. In this project, we focus on these very vulnerable neurons, simultaneously recording their electrical activity and creating an inventory of the genes that characterize them, in the brains of normal compared to Alzheimer’s disease model mice. This will allow us to identify the genes that regulate electrical activity and which may represent important novel therapeutic targets to prevent neurodegeneration.

PI_NAMEs: LUEBKE, JENNIFER I;ROUSSARIE, JEAN-PIERRE  (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Action Potentials;Acute;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid deposition;Arctic Regions;Automobile Driving;Brain;Cell Nucleus;cell type;Cells;DEK gene;Deposition;electrical property;Electrophysiology (science);entorhinal cortex;epileptiform;Equilibrium;Equipment and supply inventories;Event;excitatory neuron;experimental study;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Genes;Harvest;Hippocampal Formation;Homeostasis;Human;in silico;In Situ Hybridization;in vivo;Individual;inhibitor;Injections;Investigation;Ion Channel;Knock-in;Lesion;Link;Location;Measurement;Measures;Memory;Methods;MicroRNAs;Modeling;Molecular;Morphology;mouse model;mRNA sequencing;multimodality;Mus;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;neuronal excitability;Neurons;Neurotransmitter Receptor;new therapeutic target;novel;patch clamp;patch sequencing;Pathogenesis;Pathologic;Pathology;Pathway interactions;Perforant Pathway;Physiological;Physiology;prevent;Process;Property;Regulation;Role;Series;Slice;Symptoms;Synapses;tau aggregation;tau Proteins;Testing;transcriptome sequencing;transcriptomics;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Multimodal characterization of the mechanisms of selective vulnerability of entorhinal cortical neurons


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Human genome-wide association studies have recently identified the CASS4 gene loci (Cas Scaffold Protein Family Member 4) as a genetic risk factor for developing late-onset Alzheimer’s disease; yet, little is currently known in regards to how CASS4 affects neurobiology or neurodegenerative disease pathogenesis. In our preliminary studies, we found that CASS4 deletion causes defective recruitment of microglia to amyloid beta plaques, exacerbated neuropathology, and markedly impaired cognitive flexibility. The goals of this proposal are to further define how CASS4 impacts microglial responses, brain pathology, and neuroinflammation in mouse models of Alzheimer’s disease.

PI_NAMEs: LUKENS, JOHN R (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Ablation;Actins;Adhesions;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Amyloidosis;BCAR1 gene;Biology;Brain;Brain Pathology;Cell Line;cell motility;cell type;Cells;Central Nervous System;Cognition;Cognitive;Complex;conditional knockout;Cytoskeleton;Data;Disease;Disease Progression;Endowment;Exhibits;Extracellular Structure;Family;Family member;flexibility;Focal Adhesions;Genes;Genetic;genetic risk factor;Genetic study;genome wide association study;genomic locus;Germ Lines;Goals;Hippocampus;Human;Human Genetics;Human Genome;human induced pluripotent stem cells;Immune;Impaired cognition;Impairment;innate immune pathways;insight;Knockout Mice;Knowledge;Late Onset Alzheimer Disease;Learning;Link;Macrophage;Malignant Neoplasms;Mediating;Mediator;member;Membrane;Microglia;migration;Modeling;Molecular;mouse model;Mus;Mutation;Nervous System Disorder;Neurites;Neurobiology;Neurodegenerative Disorders;neuroinflammation;neuropathology;Pathogenesis;Pathology;Pathway interactions;Phagocytosis;Protein Binding Domain;protein complex;Protein Family;Proteins;PTK2 gene;PTK2B gene;recruit;Regulation;response;Risk;risk variant;Role;Scaffolding Protein;selective expression;Senile Plaques;Signal Transduction;Signaling Protein;Site;Structure;Tauopathies;Testing;Time;Traction;transcriptomics;Work

PROJECT_TITLE: Making a case for CASS4 in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This project aims to develop new models for prediction of cognitive outcomes including cognitive change and incident Alzheimer’s disease. Prediction models will be developed by applying advanced machine learning techniques to high-dimensional data including clinical, neuropsychological, genetic, and biomarker data. This approach will lead to predictive tools that can be effectively used in research as well as clinical decision making for patients in prodromal stages of Alzheimer’s disease or individuals with normal cognition and high-risk of developing Alzheimer’s Disease.

PI_NAMEs: EZZATI, ALI  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;aged;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease therapy;American;amyloid imaging;arm;Artificial Intelligence;Big Data;biological heterogeneity;Biological Markers;Biometry;career;career development;Classification;Clinical;clinical decision-making;clinical heterogeneity;clinical practice;Clinical Research;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cohort;comparative;Complex;computational neuroscience;cost;Data;Data Collection;data harmonization;data quality;Data Set;Data Sources;Decision Making;Dementia;demographics;Development;diagnostic accuracy;Dimensions;Disease;Disease Progression;Early Diagnosis;effective therapy;Elderly;Enrollment;Ensure;feature selection;follow-up;Foundations;functional decline;functional outcomes;Future;Genetic;Genetic Risk;global health;Goals;healthcare burden;high risk;Image;Impaired cognition;improved;Individual;innovation;International;Investigation;K-Series Research Career Programs;Life Style;Longitudinal cohort;Machine Learning;machine learning framework;machine learning method;machine learning model;machine learning prediction;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;mild cognitive impairment;model generalizability;Modeling;multidimensional data;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologist;Neurology;Neuropsychology;novel;Outcome;Participant;participant enrollment;patient oriented;Patients;Performance;Pharmaceutical Preparations;Population;pre-clinical;predict clinical outcome;Predictive Analytics;predictive modeling;predictive tools;Predictive Value;prevent;Prevention trial;Primary Prevention;prodromal Alzheimer's disease;prognostic;Research;Research Personnel;research study;risk prediction;Sample Size;Sampling;Secondary Prevention;Statistical Methods;structured data;success;Techniques;Therapeutic Effect;trial enrollment;United States;Universities;Washington;Work

PROJECT_TITLE: Predictive analytics for cognitive decline and Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE A hexanucleotide GGGGCC repeat expansion in the C9ORF72 gene is the most frequent cause of two neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). One potential pathogenic mechanism is mediated through the production of abnormal aggregating protein products. This project will assess how these abnormal protein products contribute to disease.

PI_NAMEs: MCEACHIN, ZACHARY THOMAS (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 3-Dimensional;Behavior assessment;Biology;Brain region;brain tissue;c9FTD/ALS;C9ORF72;Cells;Central Nervous System;Characteristics;Chimeric Proteins;Clinical;Codon Nucleotides;Complex;Cytoplasmic Inclusion;Data;Defect;design;Dipeptides;Disease;Drosophila genus;Event;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;Genetic Transcription;Human Pathology;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Initiator Codon;insertion/deletion mutation;insight;Interruption;Introns;Measures;Mediating;Modeling;Molecular;Motor;mouse model;Mouse Protein;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;neurotoxicity;novel;Open Reading Frames;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Play;Population;Production;protein aggregation;Proteins;Proteomics;Ribosomal Frameshifting;Ribosomes;RNA;Solubility;Spinocerebellar Ataxias;Testing;Tetracyclines;Tissue Model;Tissues;Toxic effect;transcriptome sequencing;Transgenic Mice;Translations;Untranslated RNA

PROJECT_TITLE: Mechanisms of chimeric DPR production and toxicity in c9ALS/FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Excess risk for Alzheimer’s Disease and related dementias (ADRD) persists among Black and Latino older adults, a population projected to more than double by 2060. Environmental factors—such as green space, air pollution, ambient temperature, noise, walkability, neighborhood amenities, access to transit, and neighborhood deprivation—may acutely shape the distribution of individual risk factors of ADRD (depression, diabetes, hypertension, and physical activity) in Black and Latino communities affected by unequal resources due to systemic racism. This comprehensive multi-dimensional spatial study will evaluate synergistic interactions between environmental and individual factors to identify critical environmental factors that shape ADRD risk and ADRD racial disparities.

PI_NAMEs: PESCADOR JIMENEZ, MARCIA IXCHEL (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Address;Adult;Affect;African American population;Age;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Attenuated;Behavioral;Biological;Black race;cerebral atrophy;Cognition;Cognitive;cognitive function;cognitive reserve;cohort;Communities;Data;Data Set;deep learning algorithm;dementia risk;deprivation;Diabetes Mellitus;diabetes risk;Dimensions;disability;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Funding;Green space;Health;Health and Retirement Study;healthy aging;Hypertension;Image;Impaired cognition;Individual;innovation;Institutional Racism;Latino;Life Cycle Stages;Life Experience;Link;magnetic resonance imaging biomarker;Mental Depression;Methods;Modification;Multi-Ethnic Study of Atherosclerosis;Neighborhoods;Noise;older adult;Outcome;Participant;Pathway interactions;Physical activity;Population;Prevention Research;Process;Quality of life;Race;racial disparity;racial diversity;racial population;Reasons for Geographic And Racial Differences in Stroke;resilience;Resolution;Resources;Risk;Risk Factors;Sampling;Shapes;Temperature;Time;tool;United States National Institutes of Health;walkability;Work

PROJECT_TITLE: Environmental Resources for Individual Cognitive Health/Resilience (EnRICH)

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEMSON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CLEMSON UNIVERSITY

PHR: Compared to non-Hispanic, white older adults, older Black and Hispanic adults experience higher age-adjusted rates of Alzheimer’s disease and related dementias (ADRD), disparities in healthcare access and utilization, worse quality of care at the end of life, and lower rates of advance care planning. This project will address a significant gap in knowledge regarding the complex patterns and interactions of risk factors related to dispari- ties in end-of-life care across cognition levels and races/ethnicities. The goals of this career development award are to use advanced statistical and artificial intelligence methods to understand the factors related to advance care planning and end-of-life care quality among older adults living with ADRD and their caregivers.

PI_NAMEs: RAHEMI, ZAHRA  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adherence;Adult;Advance Care Planning;Age;Ageism;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Autopsy;Big Data;Black race;career;career development;Caregiver Burden;Caregivers;Caring;Categories;Cause of Death;Cessation of life;clinical practice;Cognition;Cognitive;cognitive function;Complex;Data;Data Analytics;Data Science;Data Set;Decision Aid;Decision Making;decision-making capacity;Demographic Factors;design;Development Plans;Discipline of Nursing;Disparity;disparity elimination;Educational workshop;Emotional;end of life;end of life care;Environment;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;explainable artificial intelligence;Family;flexibility;Geriatric Nursing;Goals;hands on research;Health;Health and Retirement Study;health care availability;health care disparity;health care service utilization;health determinants;health disparity;health equity;Healthcare;Hispanic;Hospice Care;Hospitalization;hospitalization rates;Hospitals;Impaired cognition;improved;innovation;Intensive Care;Interview;K-Series Research Career Programs;Knowledge;large datasets;Lead;Life;Linear Regressions;Link;Logistics;Longitudinal Studies;Machine Learning;marginalization;Medical;Medicare;Mentors;Mentorship;Methods;Minority;Minority Health Research;Modeling;National Institute on Aging;Not Hispanic or Latino;novel;Nursing Homes;older adult;older patient;Outcome;Palliative Care;Participant;Patient Care;patient home care;Patient Self-Report;Patients;Pattern;Perception;Persons;Pilot Projects;Policies;Population;Positioning Attribute;predictive modeling;preference;Preparation;professor;programs;Proxy;Quality of Care;Race;racial determinant;racial difference;racial disparity;racial minority;racial minority population;racial population;racism;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Respondent;Risk Factors;Role;Sampling;satisfaction;Science;secondary analysis;Sexism;skills;statistical and machine learning;Statistical Methods;statistics;success;summer research;support tools;Training;Universities;Variant;Work

PROJECT_TITLE: Exploring Advance Care Planning Among Older Adults Across Racial, Ethnic, and Cognitive Differences Using Data Science


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Intraductal papillary mucinous neoplasm (IPMNs) are a common cystic tumor that is being increasingly appreciated as an important precursor to pancreatic ductal adenocarcinoma (PDA). The influence of the immune microenvironment in the development or progression of IPMN remains largely unknown. The studies proposed in this grant application will provide important knowledge regarding the role of the CX3CL1-CX3CR1 axis in recruitment and generation of M2-like macrophages, and their impact on the initiation of the immune/stroma microenvironment facilitating IPMN development, which has the potential to identify new biomarkers for risk stratification and therapeutic intervention.

PI_NAMEs: DING, LI  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Age;AGR2 gene;Animals;Applications Grants;Biological;biomarker identification;cancer invasiveness;Cells;chemokine;Clinical;CX3CL1 gene;Cystic Neoplasm;Data;Development;digital;Disease Marker;disease model;Disease Progression;Duct (organ) structure;Ductal Epithelial Cell;Dysplasia;Environment;Epithelium;Fibrosis;Fractalkine;Frequencies;Gene Expression Profile;Generations;genetic signature;Genetically Engineered Mouse;glycogen synthase kinase 3 beta;Heterozygote;High grade dysplasia;high risk;Human;Immune;immune cell infiltrate;Impairment;Infiltration;insight;Knock-in Mouse;Knock-out;Knowledge;KRAS oncogenesis;KRASG12D;Lesion;Ligands;Macrophage;Malignant - descriptor;Malignant Neoplasms;Modeling;Monitor;monocyte;Morphology;mouse model;Mucinous Neoplasm;Mus;Mutation;novel;novel marker;Nuclear;Oncogenic;overexpression;pancreas development;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Papillary;Patients;Population;premalignant;progenitor;PTPRC gene;Publications;recruit;Regulatory T-Lymphocyte;risk stratification;Role;Sampling;Signal Transduction;single-cell RNA sequencing;stem cell population;Surface;Therapeutic Intervention;transcriptomics;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions

PROJECT_TITLE: Role of the CX3CL1-CX3CR1 signaling axis in IPMN

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This research will answer critical questions about how to align the financial incentives of Medicaid- and Medicare-funded care for dual-eligible nursing home residents with AD/ADRD. In doing so, it aims to improve outcomes of nursing home residents with AD/ADRD and inform current and future directions of financial alignment and integration efforts.

PI_NAMEs: WERNER, RACHEL M (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Accountability;Acute;Admission activity;Alzheimer's disease related dementia;beneficiary;care costs;care fragmentation;Caring;Clinical;cost;Data;Dementia;dual eligible;Dual Enrollment;Enrollment;Face;financial incentive;Funding;Future;Health;Home Nursing Care;Hospitalization;Hospitals;improved;improved outcome;Incentives;Individual;Institution;Investments;Medicaid;Medicare;Medicare/Medicaid;nursing home length of stay;Nursing Homes;nursing skill;Outcome;payment;Persons;Policies;programs;Quality of Care;Quasi-experiment;Research;Risk;skills;Special needs plan;Time;trend;Work

PROJECT_TITLE: Aligning incentives across Medicaid and Medicare for nursing home residents with AD/ADRD

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

PHR: PROJECT NARRATIVE The prevalence of comorbidity between PTSD and CUD and the increasing legal status of cannabis support the need to understand how stress and cannabis interact in the brain. My recent discovery suggests that cannabis use worsens the severity of key PTSD symptoms. The experiments described in this proposal aim to identify brain circuits and molecular mechanisms underlying the synergisms between stress and cannabis that can be exploited as targets for treating the high incidence of comorbid PTSD and CUDs.

PI_NAMEs: HODEBOURG, RITCHY  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;acute stress;Affect;Astrocytes;Atrophic;Aversive Stimulus;avoidance behavior;Behavior;behavioral response;biological adaptation to stress;Brain;Cannabinoids;Cannabis;cannabis self-administration;Cell Nucleus;cell type;Cells;Chondroitin ABC Lyase;Clinical;clinically relevant;Communication;comorbidity;confocal imaging;Confocal Microscopy;Coping Behavior;Cues;Dendritic Spines;Diagnosis;digital;Disease;Drug usage;experimental study;Exposure to;Extracellular Matrix;Foundations;gamma-Aminobutyric Acid;Globus Pallidus;Immobilization;improved;in vivo;Incidence;Induced Neurons;ITGB3 gene;knock-down;Label;Legal Status;Literature;marijuana use;marijuana use disorder;Matrix Metalloproteinases;Measures;Mediating;Medical;Methods;Microinjections;Molecular;Morphology;neuroadaptation;neurobiological mechanism;Neuronal Plasticity;Neurons;Nucleus Accumbens;Output;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;Prevalence;prevent;Publishing;Rat Transgene;Rattus;reflectance confocal microscopy;response;restraint stress;Rewards;Role;Severities;Signal Transduction;Stimulus;Stress;Stress and Coping;Structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;synergism;Training;Translating;Treatment Efficacy;Treatment outcome;United States;Veterans;Viral

PROJECT_TITLE: Neurobiological mechanisms underlying changes in PTSD-like symptoms after cannabis use

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARATIVE This K01 project aims to determine the dynamic, micro-temporal influences of social and built environments on physical activity concurrently within a racially and ethnically diverse sample of youth during the summer by applying ecological momentary assessment (EMA) and social network analysis (SNA) techniques. Further, this project aims to confront multiple existing measurement limitations related to specificity, granularity, and causality while addressing multiple modifiable determinants of PA and social wellbeing at a critical time for youth in terms of their important transitional age range (12-15 years) and high-risk months (summer).

PI_NAMEs: PROCHNOW, TYLER  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adoption;Age;Behavior;built environment;career;career development;Characteristics;Classification;Collection;Complex;Data;Data Analyses;Development;Development Plans;digital phenotyping;Ecological momentary assessment;Educational workshop;Environment;Equation;ethnic diversity;Etiology;Evaluation;experience;Exposure to;follow-up;Funding;Goals;Grant;Health;Health behavior;Health equity research;Heterogeneity;high risk;Hour;improved;Individual;innovation;Internet;Intervention;Interview;Joints;Knowledge;Link;Location;Maintenance;Measurement;Measures;Mentors;Methods;Modeling;ninth grade;novel;Pathway Analysis;Perception;Physical activity;Physical assessment;Predisposition;Process;Professional Organizations;Protocols documentation;psychologic;racial diversity;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Resources;Respondent;response;Safety;Sampling;school district;Schools;self reported behavior;social;Social Environment;social influence;Social Network;Social Perception;social relationships;Social Well-Being;Specificity;Structure;Surveys;Techniques;Testing;Time;Time Study;Training;Training Activity;Work;Writing;Youth

PROJECT_TITLE: Identifying the reciprocal associations between the built environment, social networks, and physical activity among youth in the summer

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Intraspinal transplantation of stem cell-derived neurons is effective in improving sensorimotor function following spinal cord injury, yet poor transplanted cell survival continues to hinder reproducibility and clinical translation. To overcome this, we have designed a hydrogel biomaterial with tunable properties that (1) protects transplanted cells during injection via mechanical shielding and (2) releases pro-survival growth factors to overcome the toxic microenvironment. We hypothesize that encapsulating stem cell-derived neurons in this hydrogel as a combinatorial transplantation therapy will significantly improve the survival of transplanted cells and hence functional recovery following spinal cord injury.

PI_NAMEs: DOULAMES, VANESSA MADELYN (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Acute;Address;Advisory Committees;allodynia;Anatomy;Attenuated;Award;Behavioral Assay;Biocompatible Materials;Biocompatible Materials Testing;Biodegradation;Biomedical Engineering;Bolus Infusion;brain-derived growth factor;Cannulas;career;career development;Cell Death;Cell membrane;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Central Nervous System;central nervous system injury;Cervical spinal cord injury;Clinical;clinical translation;Collaborations;combinatorial;Communication;Contusions;crosslink;Data;delivery vehicle;design;Development;Development Plans;Effectiveness;Encapsulated;Engineering;Evaluation;Event;excitotoxicity;Exposure to;Female;Fibrinogen;Forelimb;Formulation;Functional disorder;functional improvement;functional outcomes;Gel;Gene Expression;Goals;Growth Factor;Health;Human Development;human induced pluripotent stem cells;Hydrogels;Hypoxia;immunodeficiency;improved;improved outcome;In Vitro;in vivo evaluation;Induced pluripotent stem cell derived human neuron;Injectable;Injections;Injury;innovation;International;Ischemia;K-Series Research Career Programs;Laboratories;Libraries;materials science;Measures;Mechanics;Membrane;Mentorship;Modeling;Motor;Nerve Degeneration;Nerve Regeneration;Neurites;neuronal survival;Neurons;Neuroprotective Agents;neurotropic;Oxidative Stress;Pathology;Peer Review;Phenotype;Polishes;Positioning Attribute;post-transplant;pre-clinical;Process;Property;protein expression;Rattus;Recombinants;Recovery of Function;regenerative;Regenerative Medicine;regenerative therapy;release factor;Reporting;Reproducibility;Resources;response;role model;Saline;Science;Scientist;Secondary to;Sensorimotor functions;Sensory;shear stress;Signal Pathway;Site;skills;Spinal;Spinal cord injury;stem cell biology;Stem cell transplant;stem cells;System;tenure track;Testing;Thinness;Training;Transplantation;transplantation therapy;Treatment Efficacy;treatment group;Universities;Vascular Endothelial Growth Factors;Vesicle;Vocational Guidance

PROJECT_TITLE: Injectable hydrogels for hiPSC-neuron therapy of spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Changes in protein N-glycosylation are a hallmark of Alzheimer’s disease. The expression of circular RNAs encoding mannosidase MAN2A1 correlate with AD progression, and we showed that they are translated. We will test the correlation of circMAN2A1 encoded proteins with AD and the contribution of the encoded proteins to changes in protein N-glycosylation.

PI_NAMEs: STAMM, STEFAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Active Sites;ADAR1;Address;Adenosine;Affect;Alpha-mannosidase;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Antibodies;beta-site APP cleaving enzyme 1;Biochemical;Biological Markers;Brain;Brain region;Cells;Cerebrospinal Fluid;circular RNA;Complex;Cytosol;Development;Disease;Disease Progression;Dolichol;dsRNA adenosine deaminase;early detection biomarkers;endoplasm;Endoplasmic Reticulum;entorhinal cortex;Enzymes;experimental study;Fractionation;Generations;Genetic Transcription;glycosylation;Golgi Apparatus;Hippocampus;Human;Immune Sera;Immunohistochemistry;in vitro Assay;in vitro testing;induced pluripotent stem cell;Inflammation;innovation;Inosine;Interferon alpha;knock-down;Lectin;Link;Mannose;Mannosidase;Measures;Modification;Molecular;mRNA Precursor;Neurofibrillary Tangles;Neurons;new therapeutic target;novel;overexpression;Parietal Lobe;Pathologic;Peptide Signal Sequences;Polysaccharides;protein expression;Protein Glycosylation;Protein Isoforms;Proteins;Research;response;RNA;RNA Editing;RNA-specific adenosine deaminase 3;Role;Serum;Severity of illness;Site;tau aggregation;tau Proteins;Testing;therapeutic target;Time;Tissues;transcriptome sequencing;Transfection;Translating;Translations;Transmembrane Domain;Western Blotting;Work

PROJECT_TITLE: Changes in protein glycosylation due to translation of mannosidases encoded by circular RNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: KNOXVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: Project Narrative This project leverages advanced artificial intelligence technology to support caregivers of persons with Alzheimer's disease and related dementias, by offering informative, interactive sessions with a social robot. Through engaging sessions, caregivers can gain vital knowledge, helpful strategies, and stress management techniques, which ultimately enhances their ability to provide care and improve their wellbeing. In the long term, our research aims to alleviate caregiver stress, promote healthier living conditions for both caregivers and persons with dementia, and improve the overall quality of dementia care.

PI_NAMEs: ZHOU, WENJUN  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adoption;Age;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Area;Artificial Intelligence;Attitude;Bathing;Behavioral;Breathing;Capsicum;care burden;caregiver education;caregiver interventions;caregiver stress;Caregiver support;Caregivers;caregiving;Caring;Communication;Communities;coping;Data;Dementia;dementia care;Dementia caregivers;design;Development;Eating;Education;Emotional;Evaluation;evidence base;experience;falls;Family member;Foundations;Friends;Future;Genetic Transcription;Goals;Guided imagery;Guidelines;Health;Health Personnel;Health Technology;healthy lifestyle;Hour;improved;insight;Institution;Insurance;interest;intervention program;Knowledge;Learning;Measures;Medicare;Modeling;novel;Outcome;Output;Participant;Personal Satisfaction;Persons;Pilot Projects;preference;Process;Process Assessment;Prognosis;programs;Psyche structure;Qualitative Methods;recruit;Research;Research Personnel;Resources;response;Risk Assessment;Robot;Robotics;Safety;Self Care;Series;Sleep;social assistive robot;Solid;Stress;stress management;Stretching;study population;Surveys;System;Techniques;Technology;technology intervention;tool;Training;Well in self

PROJECT_TITLE: Robot-based Information and Support to Enhance Alzheimer's Caregiver Health (RISE)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Leishmania donovani cause the fatal human disease visceral leishmaniasis for which the treatments are often toxic, ineffective, and are facing resistance. This proposal seeks to develop a versatile genetic tool that can be used to identify proteins that are important for parasite survival or that cause the parasites to resist drug treatments. The information gleaned from these studies could be useful in developing new drugs to treat these devastating diseases.

PI_NAMEs: YATES, PHILLIP A (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acceleration;Bar Codes;Biology;Cells;Communities;Complex;CRISPR/Cas technology;Defect;Disease;DL-alpha-Difluoromethylornithine;dosage;drug action;Drug resistance;Drug Targeting;Ensure;experience;experimental study;Expression Library;expression vector;fitness;Gene Expression Regulation;Generations;Genes;Genetic;genetic regulatory protein;Genetic Screening;Genetic Techniques;genome-wide;Genomic Library;Glean;Goals;Growth;human disease;Hyperactivity;Incidence;Individual;inducible gene expression;innovation;knock-down;Laboratories;Leishmania;Leishmania donovani;Libraries;Life Cycle Stages;loss of function;Melarsoprol;Methods;Molecular Genetics;neglected tropical diseases;new therapeutic target;novel;novel therapeutics;Open Reading Frames;Ornithine Decarboxylase;Ornithine Decarboxylase Inhibitor;overexpression;Parasites;Pathway interactions;Persons;Pharmacotherapy;Phenotype;Plasmids;protein expression;protein function;Proteins;Reproducibility;Resistance;resistance gene;resistance mechanism;Resources;Ribosomal RNA;RNA Interference;RNA interference screen;Signal Transduction;Stress;System;Time;tool;Transfection;Trypanosoma brucei brucei;Trypanosoma cruzi;Validation;vector;Visceral;Visceral Leishmaniasis;Yeasts

PROJECT_TITLE: Generation and validation of a novel inducible overexpression library for genome-scale genetic screens in Leishmania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Dietary Supplements;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE/RELEVANCE Gut microbial dysbiosis, vitamin D deficiency and inflammation and comorbid metabolic noncommunicable diseases increase with advancing age and contribute to the higher risk of Alzheimer’s Disease and Related Dementia (ADRD). These ADRD risk factors are further magnified in older persons living with HIV and the consequence of these overlapping risk factors for ADRD prevalence/incidence among older adults is unknown. Hence, using a longitudinal study design, we will delineate how much disruptions of the gut-brain axis and the metabolome of vitamin D contribute to ADRD prevalence/incidence through immune dysfunction in older adults.

PI_NAMEs: EZEAMAMA, AMARA E (contact);GIORDANI, BRUNO

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Adult;Africa South of the Sahara;Age;aged;Aging;aging population;Alzheimer's disease related dementia;Alzheimer's disease risk;Anabolism;antiretroviral therapy;Biological;Biological Availability;Biological Markers;Calcitriol;Cholecalciferol;cholinergic;Chronic;Clinical;Cognition;Cognitive;Communities;comorbidity;Consensus;cytokine;Data;dementia risk;Demographic Transitions;Detection;Diagnosis;Diagnostic;Disease;disorder risk;dysbiosis;Elderly;Enzymes;Epidemic;Epidemiology;epidemiology study;Exhibits;frailty;Frequencies;Future;General Population;gut dysbiosis;gut homeostasis;gut microbiota;gut-brain axis;High Prevalence;high risk;HIV;HIV Infections;HIV Seronegativity;human old age (65+);hyperphosphorylated tau;Immune;immune activation;Immune System Diseases;Immunity;Immunologic Markers;Impaired cognition;Impairment;Incidence;indexing;Individual;Inflammation;Inflammatory;intestinal fatty acid binding protein;Intestines;Joints;Longitudinal Studies;Malnutrition;Measurement;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolome;microbial;middle age;mild cognitive impairment;Monitor;Morbidity - disease rate;multi-component intervention;neuroinflammation;Neuropsychological Tests;Neuropsychology;neurotransmission;novel;Nutritional;Observational epidemiology;older adult;Older Population;Outcome;Pathway interactions;Persons;Pilot Projects;preclinical study;Prevalence;prevent;Process;Proteins;Proxy;psychosocial;Public Health;recruit;Reporting;Research Design;Research Infrastructure;residence;restoration;Risk;Risk Factors;Role;Sampling;Science;Serum;Severities;sex;Societies;Sum;symposium;synergism;Target Populations;Testing;Uganda;Variant;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Work;β-amyloid burden

PROJECT_TITLE: Vitamin D and Gut Microbiota and Dementia Risk in Older Adults with Chronic HIV infection and Demographically Matched Community Controls

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The protein TAR DNA Binding protein – 43 kDa (TDP-43) has been shown to be involved in the pathology of diseases including Frontotemporal Degeneration (FTD), Amyotrophic Lateral Sclerosis (ALS), limbic predominant age-related TDP-43 encephalopathy (LATE), Alzheimer’s disease (AD) and aging related memory decline. Our proposal will use advanced techniques in digital neuropathology, molecular genetics, proteomics and molecular biology to carry out an in- depth analysis of TDP-43 and its involvement in these diseases. Results from this project may inform the design of diagnostic and therapeutic compounds that target pathological TDP-43, such as PET ligands and antibodies.

PI_NAMEs: CRACCO, LAURA ;NEWELL, KATHY L (contact);RYSKELDI-FALCON, BENJAMIN

PROJECT_TERMS: Adopted;aging related;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Anatomy;Antibodies;Area;Biological Assay;Brain;Brain region;brain tissue;cellular pathology;Classification;Clinical;clinical heterogeneity;cohort;Cryoelectron Microscopy;Data;Dementia;design;Diagnostic;digital;digital imaging;Disease;DNA-Binding Proteins;Epitopes;Filament;Foundations;frontal lobe;frontotemporal degeneration;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Heterogeneity;Hippocampus;Human;Image Analysis;Immunoassay;Immunoelectron Microscopy;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;Individual;Inflammatory Response;innovation;Kinetics;Laboratories;Libraries;Ligands;limbic-predominant age-related TDP-43 encephalopathy;Maps;Mass Spectrum Analysis;Memory Loss;Methods;misfolded protein;Molecular;Molecular Biology;Molecular Conformation;Molecular Genetics;Motor Cortex;Mutation;nanobodies;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;novel;Nuclear;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Phenotype;Phosphorylation Site;Population;Positron-Emission Tomography;Post-Translational Protein Processing;Prefrontal Cortex;Property;protein TDP-43;Proteins;Proteomics;regional difference;Research Personnel;response;Role;sarkosyl;Signal Transduction;Specificity;Structural Protein;Structure;study population;Surface;tau Proteins;TDP-43 aggregation;Techniques;Technology;Testing;Therapeutic;Time;Western Blotting

PROJECT_TITLE: Investigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-A (02)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research

PHR: Project Narrative Sleep disturbances (difficulties falling or staying asleep) are common within the first month after a traumatic event and are a significant risk factor that contributes to the development of posttraumatic stress disorder (PTSD). This study will identify individuals with a trait susceptibility to posttraumatic sleep disturbances and determine the mechanisms by which these sleep disturbances increase risk of PTSD. These goals are critical to 1) identify high-risk groups toward whom preventative treatments can be targeted, and 2) inform the development of sleep-focused treatments that help lower risk of PTSD.

PI_NAMEs: REFFI, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accident and Emergency department;actigraphy;Acute;Aftercare;Behavioral;Biological Markers;career;Data;Data Analyses;Data Set;Development;Disease;disorder risk;Early Diagnosis;Early identification;Early Intervention;Etiology;Evidence based treatment;experience;Exposure to;Extinction;falls;Fright;Future;Galvanic Skin Response;Goals;Guide prevention;Heart Rate;high risk;high risk population;Impairment;Individual;Intervention;Lead;Learning;Left;Link;longitudinal analysis;Measures;Mental disorders;Methods;mortality risk;National Institute of Mental Health;Outcome;Patient Dropouts;Patient Outcomes Assessments;Patients;Physiological Processes;Polysomnography;Populations at Risk;post-trauma;Post-Traumatic Stress Disorders;Predisposition;premature;prevent;Prevention;Prevention strategy;Preventive;preventive intervention;Preventive treatment;prospective;Psychophysiology;Recovery;REM Sleep;Research;Research Design;Research Personnel;response;Risk;Risk Factors;screening;Severities;sexual assault;Signal Transduction;Sleep;Sleep disturbances;sleep physiology;Societies;Stimulus;Strategic Planning;Stress;Suicide attempt;suicide rate;Survivors;Techniques;Testing;Training;trait;Trauma;Trauma patient;traumatic event;Triage;Vehicle crash;Vulnerable Populations;Work

PROJECT_TITLE: Identifying sleep-related risk factors for PTSD and their underlying mechanisms

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In this project, the applicant will implement advanced multi-modal measures of AD pathophysiology, including cutting-edge blood biomarkers, to investigate in what context, hormone therapy alters middle- aged and older women’s susceptibility to cognitive decline due to AD pathology in-vivo. This project combines neuroimaging, blood, cognitive, clinical, and genetic data across well-phenotyped observational studies and clinical trials to address the extent to which AD pathology is determined by the timing of HT use and the moderating role of genetic risk and modifiable risk factors. The project outcomes will: i) form a key step towards understanding biological basis for adverse and potentially favorable responses to HT ii) contribute to scientifically grounded guidance on HT and iii) more broadly inform how men and women may differ in terms of AD risk factors.

PI_NAMEs: COUGHLAN, GILLIAN THERESA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: abeta accumulation;Address;Affect;Age;aged;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Area;arm;astrogliosis;axon injury;Big Data;Biological;Biological Markers;Blood;Board Certification;Brain;cardiovascular disorder risk;career;Clinical;clinical diagnosis;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive neuroscience;Collaborations;Congresses;Data;Data Set;Dementia;Deposition;Diagnosis;Disease Progression;Education;Elderly;Endocrinologist;Enrollment;entorhinal cortex;Exposure to;Female;Functional disorder;General Hospitals;Genetic;Genetic Risk;Glial Fibrillary Acidic Protein;Goals;Gynecologist;Health;hormone therapy;Hormones;Impaired cognition;in vivo;Individual;Inflammation;innovation;Intercept;Knowledge;late life;Lateral;Latino;Least-Squares Analysis;Letters;Light;Longitudinal cohort study;longitudinal positron emission tomography;Malignant Breast Neoplasm;Massachusetts;Measures;medical schools;Meditation;men;menopausal hormone therapy;Menopause;Mentorship;Meta-Analysis;Methods;middle age;Modeling;modifiable risk;multimodality;neocortical;Neurobiology;neurofilament;neuroimaging;Neurologist;novel;Observational Study;older women;Outcome;overtreatment;Participant;Pathologic;Patient Self-Report;personalized approach;Persons;Phase;Phenotype;placebo group;Placebos;Plasma;Positioning Attribute;Positron-Emission Tomography;Postmenopause;pre-clinical;Predisposition;Prevalence;Prevention strategy;programs;Randomized;Randomized, Controlled Trials;Registries;Reporting;Research;Research Personnel;response;Risk Factors;Role;Sampling;sex;Sex Differences;skill acquisition;skills;statistics;Structure of inferior temporal gyrus;tau aggregation;tau Proteins;Testing;time use;Training;treatment duration;treatment strategy;Uncertainty;United States;virtual;Wisconsin;Woman;Women's Health;Work

PROJECT_TITLE: Menopause, hormone therapy and Alzheimer's disease clinicopathology: An in vivo perspective

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal will study the interplay between epigenetics of immune cells and social determinants of health in Latinos with Alzheimer's disease and frontotemporal lobe dementia from an established NIH funded Multi- Partner Consortium to Expand Dementia Research in Latin America (ReDLaT) cohort. This project aims to both compare and contrast molecular changes within immune cells of diverse people's genes associated with Alzheimer's disease and frontotemporal lobe dementia and links to social determinants of health. This project addresses the lack of diversity in epigenetic studies of Alzheimer's diseases and related dementias and advances efforts towards global strategies of addressing dementia disparities.

PI_NAMEs: CORLEY, MICHAEL JAY (contact);IBANEZ, AGUSTIN M.;SANTAMARIA-GARCIA, HERNANDO

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Aberrant DNA Methylation;Address;Affect;age acceleration;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Apolipoprotein E;Area;Argentina;Atlases;Autopsy;Biological;Biological Aging;Biological Markers;Biology;Blood;Brain;brain health;brain tissue;Brain-Derived Neurotrophic Factor;Candidate Disease Gene;cardiometabolism;Caucasians;Cells;Chile;Clinical;Cognitive;cohort;Cohort Studies;Collection;Colombia;Country;Data;Data Set;Dementia;dementia risk;Diagnosis;Disease;Disparity;DNA Methylation;DNA methylation profiling;Economically Deprived Population;Environment;Environmental Risk Factor;epigenetic clock;epigenetic marker;Epigenetic Process;epigenomics;ethnic identity;Ethnic Origin;European;Exhibits;Frontotemporal Dementia;Funding;gene regulatory network;Generations;Genes;Genetic;Genome;genome-wide;Genomics;health data;health disparity;health inequalities;Health Status;Heterogeneity;Hispanic;Human;human old age (65+);Immune;Income;Individual;Inequality;Inflammation;Inflammatory;Intervention;Knowledge;Latin America;Latin American;Latino;Latino Population;lens;Link;Lobe;low and middle-income countries;low income country;Measures;Mediating;methylation biomarker;methylation pattern;Modification;Molecular;mortality risk;neural correlate;neuroimaging;Neuropsychology;novel strategies;Nucleic Acid Regulatory Sequences;Outcome;Participant;Persons;Phenotype;Play;Population;presenilin-1;presenilin-2;Prevalence;Prevention;Prevention strategy;Protocols documentation;Race;recruit;Research;Rest;Risk;Role;Sampling;social;social adversity;social disparities;social health determinants;socioeconomic disadvantage;Socioeconomic Status;Standardization;Stress;Study of Latinos;tau Proteins;Testing;Tissues;Underrepresented Populations;United States National Institutes of Health;Validation

PROJECT_TITLE: Social epigenetics of Alzheimer's disease and related dementias in Latin American countries

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed project will be the first to study the efficacy of a mental health treatment for parents of children with pediatric feeding disorder (PFD). This intervention uses Focused Acceptance and Commitment Therapy techniques, is tailored to parents of children with PFD, and has the potential to improve parent mental health in just 2 sessions. If successful, this project will result in a highly innovative way to address both parent mental health and child health (e.g., quality of life, feeding behaviors) in pediatric treatment settings.

PI_NAMEs: BAKULA, DANA M (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adherence;Affect;Anxiety;Area;attentional control;Award;Behavior;behavior observation;career;Caring;Child;Child Behavior;Child Health;Child Rearing;Childhood;Clinical;clinical implementation;Clinical Trials;Code;Conduct Clinical Trials;Disease;Eating;effective therapy;efficacy evaluation;efficacy study;efficacy testing;experience;Family;feeding;Feeding behaviors;flexibility;follow-up;Funding;Goals;health care service utilization;Hyperphagia;implementation outcomes;implementation science;Improve Access;improved;innovation;Intervention;Interview;Malnutrition;Measures;Mediating;Mental Depression;Mental Health;Multivariate Analysis;National Institute of Mental Health;Neurodevelopmental Disorder;Outcome;Outcome Measure;parenting intervention;Parents;Participant;Patients;Perception;Positioning Attribute;Positive Reinforcements;post intervention;programs;psychologic;Psychologist;Quality of life;Randomized, Controlled Trials;Recommendation;Reporting;Research;Scheme;Scientist;Stress;Stretching;success;Techniques;Testing;Therapeutic Intervention;Thinness;Time;Training;treatment center;treatment effect;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Brief Mental Health Treatment For Parents of Children with Pediatric Feeding Disorder

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]