NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: FOXE, JOHN J (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Advocacy;Animal Behavior;Architecture;archive data;Articulation;autism spectrum disorder;Basic Science;Brain;Budgets;cellular imaging;Charge;Clinical;Clinical Research;Communication;Communities;community advisory board;community engagement;Community Health Education;Competence;Consultations;Core Facility;cost effectiveness;cultural competence;data archive;data sharing;Dedications;density;design;Development;disability;Disease;diversity and inclusion;early life exposure;Education and Outreach;Educational Activities;Educational workshop;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;Evolution;experience;Eye;Family;federal policy;Fostering;Funding;Funding Agency;Future;Grant;Heart;High Performance Computing;high risk;Human;Informatics;Infrastructure;innovation;insight;Intellectual and Developmental Disabilities Research Centers;International;Kinesiology;Knowledge;Leadership;Linguistics;Lobbying;member;Mink;Mission;Modernization;molecular imaging;Morals;multisensory;neurodevelopment;neuroimaging;neuroinflammation;neurophysiology;Newsletter;open data;operation;Parenting Education;Parents;Pathologic;Persons;Phenotype;Policies;Policy Maker;Postdoctoral Fellow;postdoctoral investigator;pre-doctoral;prevent;professor;programs;Quality Control;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientific Advances and Accomplishments;Scientist;Series;social media;Spanish;Spanish/English;Stress;symposium;System;Systems Integration;Technical Expertise;Techniques;Technology;technology development;Training;Translating;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Neuroscience research is critical for development of strategies to prevent, diagnose and treat diseases of the nervous system. This broadly based training program is designed to provide the next generation of researchers with a solid foundation in the fundamentals of neuroscience and strong, cutting-edge research training in basic and translational neuroscience, emphasizing rigorous experimental design and data analytic approaches.

PI_NAMEs: HERMAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Predoctoral Training Program in the Neurosciences


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: OAKES, LEONA ASHLEY (contact)

PROJECT_TERMS: Academic achievement;Adaptive Behaviors;Area;autism spectrum disorder;Behavior;Behavior assessment;Behavioral;behavioral health;Clinical;Clinical assessments;clinical care;clinical phenotype;Clinical Research;Clinical Sciences;Clinical Trials Design;Cognition;Cognitive;Collaborations;Common Data Element;Communities;community engagement;Complex;Consult;Consultations;cost effective;Data;data acquisition;data sharing;Dedications;design;Development;Developmental Disabilities;Diagnostic tests;disability;Disability Evaluation;Disability phenotype;Disability research;Disease;disease model;diversity and inclusion;Electronic Health Record;Ensure;Etiology;experience;Faculty;Family;Fostering;Future;Genotype;graduate student;Human;Human Development;Impaired cognition;improved;Individual;Infrastructure;innovation;insight;Institution;Instruction;instrument;Intake;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;International;investigator training;Measurable;Measures;Methods;Mission;Modeling;motor impairment;multimodality;Neurodegenerative Disorders;Neuropsychology;novel;Outcome;outreach;Parents;Participant;Patient Recruitments;Patients;Persons;phenomenological models;Phenotype;PhenX Toolkit;Population;Postdoctoral Fellow;practice-based research network;pre-clinical;Process;Proxy;recruit;Registries;remote assessment;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Rett Syndrome;Sampling;Science;Sensory impairment;Services;social media;Source;Spielmeyer-Vogt Disease;Standardization;standardize measure;Symptoms;System;Techniques;Terminology;Testing;Therapeutic;tool;Training;training opportunity;trait;Translational Research;Translations;Universities;Work

PROJECT_TITLE: Human Phenotyping & Recruitment Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Batten Disease;Brain Disorders;Clinical Research;Dementia;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: WANG, KUAN HONG  (contact)

PROJECT_TERMS: Acceleration;Attention;Auditory;Auditory area;Auditory Evoked Potentials;Auditory Perception;auditory processing;auditory stimulus;autosome;base;Biological Assay;Biological Markers;biomarker identification;Blindness;calcium indicator;Categories;cell type;Cells;Ceroid;Child;Childhood;Chromosome 16;Chronic;Clinical;Clinical Trials;CLN3 gene;cognitive function;Data;Dementia;density;design;Development;Disease;Disease Marker;disease model;Disease Progression;DNA Sequence Alteration;early adolescence;effectiveness testing;Electroencephalography;endophenotype;excitatory neuron;experimental study;Frequencies;Future;Hearing Tests;Human;human disease;Hypertrophy;Impaired cognition;improved;improved outcome;in vivo two-photon imaging;Individual;inhibitory neuron;innovation;Intellectual and Developmental Disabilities Research Centers;Interneurons;Intervention;juvenile neuronal ceroid lipofuscinosis;Lead;Lipofuscin;lipopigments;Measurement;Measures;Memory;Methods;Modeling;Motor;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neurologic;neuromechanism;neuron loss;Neuronal Ceroid-Lipofuscinosis;Neurons;neuropathology;neurophysiology;novel therapeutics;Outcome Measure;Participant;Pathology;Patient-Focused Outcomes;patient/disease registry;Patients;Pattern;Persons;Phonetics;Positioning Attribute;pre-clinical;preclinical development;Reporter;Reporting;Research Project Grants;response;Retinal Diseases;Seizures;semantic processing;Sensory;Severities;Severity of illness;Speech Perception;Spielmeyer-Vogt Disease;Staging;Techniques;Testing;therapeutic effectiveness;therapeutic evaluation;Time;Transgenic Mice;Universities;verbal;Work;young adult

PROJECT_TITLE: Bridging the translational divide from cells to patients: toward reliable neuromarkers of Batten disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: ZHONG, JIANHUI  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;analysis pipeline;Anatomy;animal data;Animals;Archives;auditory processing;Augmented Reality;Biological Assay;Biological Markers;Brain;Brain imaging;Cell Nucleus;Cells;Child;Childhood;Cognitive;Collaborations;Collection;college;Complex;Computer software;computerized data processing;Consult;cost;Data;data acquisition;Data Analyses;data analysis pipeline;data repository;data submission;Dedications;density;design;Development;developmental disease;Disease;Disease Progression;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Environment;Event-Related Potentials;experience;Experimental Designs;Faculty;Frequencies;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Gait;Goals;Grant;Group Meetings;Human;human data;Image;imaging capabilities;Imaging Device;imaging modality;imaging system;Imaging Techniques;improved;Individual;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Investigation;investigator training;juvenile neuronal ceroid lipofuscinosis;Learning;Letters;Link;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Marker Discovery;Measurement;Measures;Medical center;member;Methodology;Methods;Modernization;molecular imaging;Motion;Motor;mouse model;multimodality;neural;neuroimaging;neurophysiology;next generation;nonhuman primate;novel;Participant;patient population;Patients;Persons;Phenotype;Physiologic pulse;Population;Positron-Emission Tomography;Postdoctoral Fellow;Posture;Procedures;Productivity;Protocols documentation;reconstruction;recruit;repository;Research;Research Personnel;Research Project Grants;Resolution;Resources;Sensory;Services;Spielmeyer-Vogt Disease;square foot;Students;Supervision;synergism;System;Systems Integration;Techniques;Testing;Time;tool;Training;Translational Research;transmission process;United States National Institutes of Health;Universities;virtual;Virtual and Augmented reality;virtual reality;virtual reality environment;visual tracking;Walking;Work

PROJECT_TITLE: Translational Neuroimaging & Neurophysiology Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative There is a need in the science and medical health fields associated with brain for expert contributions from engineering, sciences and mathematics in order to make lasting advances. The proposed Cross Disciplinary Neural Engineering (CDNE) training program will train future leaders in the field of neural engineering able to work across the disciplinary boundaries of engineering, sciences, mathematics, and neurosciences and human brain health. CDNE trainees will be able to communicate and understand deeply the needs and science of their collaborators, and thereby able to produce lasting advances in both basic neurosciences and the treatment of human brain health.

PI_NAMEs: GLUCKMAN, BRUCE J (contact)

PROJECT_TERMS: Engineering;neural;Training Programs

PROJECT_TITLE: Cross-Disciplinary Neural Engineering (CDNE) Training Program


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: MAJEWSKA, ANNA K (contact)

PROJECT_TERMS: Address;Algorithms;Animal Model;Animals;Biological;Biological Process;Biometry;Brain;cellular imaging;Clinical Sciences;Collaborations;Communities;Complex Analysis;Computer software;Computers;Consultations;Custom;Data;data acquisition;Data Analyses;Data Collection;data management;Data Set;data sharing;Dedications;design;Ensure;Equipment;experience;Experimental Designs;experimental study;Facility Designs;Faculty;Human;Image;Image Analysis;image processing;Imaging Device;imaging modality;improved;In Vitro;in vivo;in vivo imaging;Individual;Infrastructure;instrumentation;Intellectual and Developmental Disabilities Research Centers;interest;Label;Laboratories;Laboratory Research;member;Methodology;Methods;Microscopy;Modification;molecular imaging;multi-photon;Performance;Phase;Play;Process;Productivity;programs;Protocols documentation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Scientist;Signal Pathway;spectrograph;Standardization;success;superresolution imaging;System;Technical Expertise;Techniques;Technology;theories;Time;Tissues;tool;Training;Translational Research;ultra high resolution;Universities;Viral;Viral Vector

PROJECT_TITLE: Cell & Molecular Imaging Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The objective of this Research Project Grant is to develop methods for modeling the spread of tau tangles, which are a hallmark of Alzheimer’s disease, along the structural network of the brain. Novel artificial intelligence tools will be developed that accurately predict the progression of tau. The proposed imaging techniques are expected to facilitate the prognosis and monitoring of Alzheimer’s disease.

PI_NAMEs: DUTTA, JOYITA  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: aging brain;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;amyloid imaging;Anatomy;Animal Model;Artificial Intelligence;Biological;Biological Markers;biomarker development;Brain;Brain region;Characteristics;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Complex;Computer Models;connectome;Data;Databases;deep learning;Dementia;demographics;Diffusion;Diffusion Magnetic Resonance Imaging;Drug Exposure;Elderly;Ensure;Epidemic;Evolution;Exhibits;explainable machine learning;Fiber;Future;Goals;Grant;Graph;graph neural network;Human;human subject;Image;Imaging Techniques;Impaired cognition;in vivo;Individual;Learning;Length;longitudinal positron emission tomography;Machine Learning;machine learning framework;machine learning model;Magnetic Resonance;Maps;Mathematics;Measures;medial temporal lobe;member;Memory impairment;Methods;Modeling;Monitor;multimodality;Neocortex;Nerve Degeneration;neural;Neuroanatomy;Neurobiology;Neurofibrillary Tangles;neuroimaging;novel;Outcome Measure;Paper;Pathologic;Pathway interactions;Pattern;personalized predictions;Phase;Physics;Pittsburgh Compound-B;Positron-Emission Tomography;pre-clinical;preclinical development;predictive modeling;prevent;primary outcome;prion-like;Process;Prognosis;prognostic tool;progressive neurodegeneration;Proteins;rate of change;Research;Research Project Grants;Resolution;Resources;Rest;Role;Sample Size;Senile Plaques;serial imaging;Site;spatiotemporal;Stereotyping;Structure;tau aggregation;tau Proteins;Therapeutic Trials;tool;Training;training data;Validation;white matter

PROJECT_TITLE: Longitudinal predictive modeling for tau in Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PI_NAMEs: CORY-SLECHTA, DEBORAH A (contact)

PROJECT_TERMS: Affect;analytical method;Animal Behavior;Animal Model;Behavior;Behavioral;Behavioral Assay;behavioral study;Biological Assay;Cells;Cognition;Complex Analysis;Computer software;Consultations;Data;Data Analyses;Data Collection;Dedications;design;Development;Ensure;Equipment;experimental study;Faculty;Generations;Genes;Goals;Individual;Infrastructure;insight;Intellectual and Developmental Disabilities Research Centers;Intervention;Investigation;Laboratories;Laboratory Research;large datasets;Leadership;Link;Measures;medical schools;member;Methodology;Methods;morris water maze;neural;neuronal patterning;Neurons;neurophysiology;Neurosciences Research;new technology;Phase;Play;Population;Protocols documentation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Rodent Model;Sensory;social;Social Behavior;Techniques;theories;Training;Universities;Work

PROJECT_TITLE: Animal Behavior & Neurophysiology


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The cell of origin for Ewing sarcoma and the mechanisms of tumor initiation and progression are a matter of constant debate. My project takes advantages of an innovative zebrafish genetic model of Ewing sarcoma to gain new insights into understanding the developmental origin of that cancer, and to investigate the role of proteoglycan-mediated signaling in cancer and cancer niche cells in tumor initiation and progression. In this work I will test a new strategy targeting the enzymes involved in heparan sulfate proteoglycan metabolism for Ewing sarcoma treatment.

PI_NAMEs: VASILEVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Address;Advisory Committees;Affect;antagonist;Apoptosis;Appearance;behavioral study;Bioinformatics;biomarker identification;Bone Tissue;Cancer Biology;cancer cell;career;Cell Differentiation process;Cell Line;Cell Lineage;cell motility;Cell Proliferation;Cell Survival;cell transformation;cell type;Cells;Communication;Communities;comparative;Complex;CRISPR/Cas technology;Data;Data Analyses;Dedications;Development;Developmental Biology;Developmental Cell Biology;Dimethyl Sulfoxide;Disease;Effectiveness;Enzymes;epigenomics;Ewings sarcoma;EWSR1 gene;experience;Fibroblast Growth Factor Receptors;Fishes;FLI1 gene;Foundations;Genes;Genetic;Genetic Models;genome editing;Goals;Heparan Sulfate Proteoglycan;Heparanase inhibitors;high resolution imaging;Home;Human;human disease;Image;imaging approach;In Situ Hybridization;In Vitro;in vivo;in vivo Model;inducible Cre;innovation;insight;Institution;Knock-out;Label;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammals;MAPK3 gene;Mediating;Mentors;Mentorship;Metabolism;Modeling;molecular targeted therapies;mosaic;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Neural Crest;Normal Cell;Normal tissue morphology;novel strategies;overexpression;Pathology;patient prognosis;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;Predisposition;professor;Proliferating;Proteoglycan;Proteomics;Recurrent disease;Reporter;Research;Resolution;Resources;RNA;RNA marker;Role;Scheme;Signal Transduction;single cell genomics;single-cell RNA sequencing;small molecule;Soft Tissue Neoplasms;stem cell biology;tenure track;Testing;Tissues;Training;transcriptomics;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;tumorigenesis;Tumorigenicity;Validation;Work;Xenograft Model;Xenograft procedure;Zebrafish;zebrafish genome

PROJECT_TITLE: Targeting proteoglycan-mediated signaling in Ewing sarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GRAND FORKS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Project Narrative The ND INBRE is dedicated to priming the pipeline for the next generation of researchers and healthcare professionals. The ND INBRE focuses on providing undergraduate student research and training, enhancement of STEM activities in the K-12 system, and providing research infrastructure that serves and strengthens all partners of the program.

PI_NAMEs: SENS, DONALD A. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Agriculture;American Indians;Award;base;Biomedical Research;career;college;community based participatory research;County;Dedications;Doctor of Medicine;Doctor of Philosophy;Engineering;Environment;Evaluation;Faculty;Fees;Foundations;frontier counties;Goals;graduate student;Health;Health Professional;Healthcare;high school;High School Student;higher education;Home;improved;Infrastructure;Institution;junior high school;Knowledge;Mentors;Middle School Student;next generation;North Dakota;peer;Persons;Population;Postdoctoral Fellow;posters;Privatization;programs;Research;Research Infrastructure;Research Personnel;Scholarship;Schools;Science;science education;science teacher;Services;Students;success;System;Technology;Training;tribal college;undergraduate research;undergraduate research experience;undergraduate student;Universities

PROJECT_TITLE: ND INBRE Health & the Environment


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Rural Health

PROJECT_TERMS: Advisory Committees;Agriculture;American Indians;base;career;Career Choice;Cities;Communities;community college;County;Dedications;density;Development;Dryness;Engineering;Environment;Equation;equity, diversity, and inclusion;Extramural Activities;Faculty;Food;frontier counties;Funding;Goals;Health;health disparity;Health Professional;high school;Hospitals;Industrialization;junior high school;land use;Leadership;Malignant Neoplasms;Maps;medical schools;meetings;New York City;next generation;North Dakota;Outcome;peer;Persons;Population;Population Density;Production;Program Evaluation;programs;Request for Applications;Research;Research Infrastructure;Research Personnel;Rural;Science;science teacher;Services;Severities;Site;Students;success;Testing;Travel;undergraduate research;undergraduate student;Weather


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: SOMJI, SEEMA  (contact)

PROJECT_TERMS: Admission activity;Adopted;American Indians;Authorship;clinical translation;community college;design;Doctor of Philosophy;Educational process of instructing;Educational workshop;Environment;Faculty;Goals;Graduation Rates;Health;Health Occupations;Healthcare;Laboratories;Laboratory Procedures;Leadership;Mentors;Minor;payment;Peer Review;Pilot Projects;pilot test;Postdoctoral Fellow;postgraduate education;programs;Publications;Research;Research Personnel;student participation;Students;Study Section;success;summer program;Techniques;Training;Training Programs;transfer student;Translational Research;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Visit

PROJECT_TITLE: Mentoring Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Narrative The aberrant accumulation of tau is linked to neuronal loss and cognitive dysfunction in Alzheimer’s disease and other tauopathies. Based on our exciting preliminary data, I propose DnaJB6 as a potential target for mitigating tau pathology. Understanding more about the interactions between tau and DnaJB6 will provide fundamental knowledge that may be applicable to other DnaJ family members and additional aggregating proteins, which ultimately may aid in the development of novel therapeutics.

PI_NAMEs: ESQUIVEL, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;aging population;Alzheimer's Disease;Amyloid;antagonist;Behavior;Behavioral;Bilateral;Biochemical Process;Biological Assay;Biology;Biosensor;Brain;brain health;brain tissue;Cause of Death;Cell model;Cells;Clinical assessments;Cognition;Cognitive;Cognitive deficits;cognitive function;Data;Dementia;Deposition;Development;Disease;Disease Progression;effective therapy;experimental study;Family;Family member;Fluorescence;Fluorescence Resonance Energy Transfer;Genes;Goals;Health;heat-shock proteins 40;Hippocampus;Histologic;Huntington gene;Impaired cognition;improved;in vitro Assay;in vivo;inhibitor;interest;knock-down;Knowledge;Label;Link;Literature;member;Molecular;Molecular Chaperones;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;neurotoxicity;novel;novel therapeutics;Outcome;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;polyglutamate;prevent;protective pathway;protein aggregation;protein protein interaction;protein TDP-43;Proteins;Proteomics;Recombinants;Regulation;Research;resilience;Role;screening;Severities;small hairpin RNA;Surface Plasmon Resonance;synuclein;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic development;therapeutically effective;Toxic effect;Transgenic Mice;Translating;virtual;Work

PROJECT_TITLE: DnaJB6 as a novel regulator of tau


NIH_SPENDING_CATS: Cancer

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE The NCI-designated Basic Laboratory Cancer Center at the Salk Institute for Biological Studies provides a rich training environment for postdoctoral fellows as they advance their careers in cancer research. In addition to rigorous, hands-on training in experimental research provided by faculty mentors, the proposed T32 Cancer Heterogeneity, Immunity, and Microenvironment (CHIME) Training Program provides workshops in cutting-edge technologies, as well as exposure to local clinicians and the problems they face while treating patients. These training elements, together with an array of career development opportunities, provide a solid foundation on which Salk T32 Fellows can build independent, research-intensive careers to help move the field toward more durable and selective cancer therapies.

PI_NAMEs: HARGREAVES, DIANA CLARE;KAECH, SUSAN M (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


PROJECT_TERMS: Admission activity;Animal Behavior;Animals;Award;base;Behavioral;Cell Separation;Centers of Research Excellence;Collaborations;commercialization;Confocal Microscopy;Development;Educational process of instructing;Educational workshop;Environment;Equipment;Faculty;Fatigue;Fee-for-Service Plans;Flow Cytometry;Funding;Goals;graduate student;Health;Health Professional;Individual;Investigator-Initiated Research;Laboratories;Letters;Mentors;Metals;Methods;Microdissection;Microscopy;Modernization;next generation;Pathology;Postdoctoral Fellow;Process;programs;Research;Research Personnel;Research Support;Resources;Sampling;Specimen;Students;Study Section;Technology;theories;Time;Training;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Research Cores


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PROJECT_TERMS: American Indian Population;Area;Award;Bioinformatics;Biometry;Clinical Research;clinical translation;Collaborations;Communities;community engaged research;Community Medicine;Computer software;cultural values;data mining;Dedications;Disease;Environment;Epidemiology;Event;Faculty;Family Practice;Funding;Health;health disparity;Home;Individual;Informatics;Institution;Joints;Knowledge;Malignant Neoplasms;Medical Informatics;Medicine;member;National Institute of General Medical Sciences;operation;Pathology;programs;Recording of previous events;recruit;Research;Research Design;Research Personnel;Resources;Translational Research;Tribes;U-Series Cooperative Agreements;United States National Institutes of Health

PROJECT_TITLE: Informatics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Apolipoprotein E (ApoE) represents the most significant genetic risk factor for Late-onset Alzheimer’s disease (LOAD), the most common type of dementia that affects more than 6 million people in the United States. However, even though the same ApoE allele confers risk in all populations, the effect sizes differ significantly by genetic ancestry. The proposed research aims to identify variants and physiological pathways that modify ApoE-associated LOAD risk in non-Hispanic Black, Hispanic/Latino, and non-Hispanic White individuals and evaluate the roles of race/ethnicity and ancestry in LOAD risk modeling.

PI_NAMEs: DURODOYE, RAZAQ OLUMIDE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Affect;African American population;African ancestry;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Apolipoprotein E;attributable risk;Automobile Driving;Bioinformatics;Biological;Black Populations;Black race;burden of illness;Cessation of life;clinical training;Committee Members;Complex;cost;Data;Data Set;Dementia;dementia risk;Disease;diverse data;Doctor of Philosophy;Economic Burden;Education;Ethnic Origin;Ethnic Population;European;experience;Frequencies;Functional disorder;Gene Frequency;Genes;Genetic;Genetic Diseases;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genotype;Health Sciences;Healthcare;Hispanic;human old age (65+);Individual;insight;Intervention;Investigation;Late Onset Alzheimer Disease;Latino;Latino Population;lipid metabolism;Low Prevalence;marginalization;Medical;Memory Loss;Modeling;Modification;multi-ethnic;multilevel analysis;Neurocognitive;Neurodegenerative Disorders;Not Hispanic or Latino;novel strategies;older adult;Pathway interactions;Persons;Physicians;Physiological;Play;Population;Population Genetics;Population Heterogeneity;Prevalence;protective allele;Race;racial difference;racial population;Research;Risk;Risk Estimate;Risk Factors;risk variant;Role;Scientist;Sequence Analysis;Single Nucleotide Polymorphism;skills;Source;Statistical Data Interpretation;Statistical Distributions;Testing;therapy development;Training;Training Programs;Underserved Population;United States;Universities;Variant;whole genome;Work

PROJECT_TITLE: Identifying genetic variants that modify the effect size of ApoE alleles on late-onset Alzheimer's disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


PROJECT_TERMS: Address;Affect;Award;Development;Doctor of Medicine;Doctor of Philosophy;Environment;experience;faculty research;Funding;Graduation Rates;Grant;Health;Health Occupations;high school program;infrastructure development;Institution;interest;junior high school;medical schools;posters;Program Research Project Grants;programs;Research;research and development;response;Rural Population;Students;Study Section;Teacher Professional Development;undergraduate research;undergraduate research experience;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Developmental Research Project Program


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The distribution of aggregated hyperphosphorylated tau (p-tau) in the brain correlates well with cognitive impairments observed in different stages of Alzheimer’s disease (AD). AD is currently untreatable, and the mechanisms underlying p-tau aggregation in AD are not fully understood. The proposed research plan will propel small molecule therapeutics that curtail human p-tau aggregation (isoform 1N4R) through lead optimization and proof of concept studies to improve our understanding of the mechanisms underlying AD and tauopathies.

PI_NAMEs: FORTIN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: ABCB1 gene;absorption;Acute;Age Months;Alzheimer's Disease;Alzheimer's disease related dementia;Ames Assay;Animal Model;Area;Behavior;Binding Proteins;Biological;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;Caco-2 Cells;Cell Culture Techniques;Cell Death;Chemical Structure;Chemicals;Cognition;college;Communities;Cytoprotection;cytotoxicity;Data;Deposition;design;Development;Diagnostic;Disease Progression;Dose;drug development;drug discovery;Drug Kinetics;efficacy study;Ensure;Equilibrium;Excretory function;Fostering;Genes;Genetic;Goals;Grant;Human;hydrophilicity;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;inhibitor;interest;Intestinal Absorption;Intraperitoneal Injections;Investigation;Knowledge;Language;lead optimization;Link;lipophilicity;Measures;Medicine;Mentors;Metabolism;Michigan;Microsomes;Modeling;Molecular Biology;mouse model;Mouse Strains;Movement;multidisciplinary;Mus;mutant;Nerve Degeneration;Neurofibrillary Tangles;Neurosciences;Neurosciences Research;neurotoxic;neurotoxicity;novel;Organ;Organic Chemistry;Pathologic;Pathologist;Permeability;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Plasma;pre-clinical;preclinical study;Preclinical Testing;Preparation;programs;Property;Protein Isoforms;Recombinants;Research;Research Personnel;Rodent Model;Safety;safety assessment;screening program;Senile Plaques;skills;small molecule;small molecule inhibitor;small molecule therapeutics;Solubility;spatiotemporal;tau aggregation;tau Proteins;tau-1;Tauopathies;Technology;Testing;Time;Tissues;Toxicology;Training;Transgenic Mice;Transgenic Organisms;Translational Research;translational study;Universities;Veterinary Medicine

PROJECT_TITLE: Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent model

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: NARRATVIE OVERALL Developmental Biology research is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. Our goals in this Phase III COBRE are to consolidate the progress we have made in Phases I and II by welcoming new Developmental Biologists into our community through the support of Pilot Projects and to expand the services offered by our Imaging and Bioinformatics and Pathways Cores, while at the same time positioning them for sustainability when COBRE funding ends.

PI_NAMEs: THOMPSON, LINDA F (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;Advisory Committees;Age;Appointment;Area;Bioinformatics;Biomedical Research;Caenorhabditis elegans;Cardiovascular system;career;Cell Culture Techniques;Cell model;Centers of Research Excellence;Communities;competitive environment;Core Facility;Development;Developmental Biology;Disease;Doctor of Philosophy;Dropout;Drosophila genus;Environment;Epigenetic Process;Faculty;Fertilization;functional genomics;Funding;Future;Genome;Genomic approach;Goals;Hematopoietic stem cells;Hereditary Disease;Human;human disease;human model;Image;Immune system;Infrastructure;Institution;Interdisciplinary Study;International;Journals;Laboratories;member;men;Mentors;model organism;Molecular;Mus;Mutation;novel therapeutic intervention;Oklahoma;operation;Pathway interactions;Phase;Physiological Processes;Pilot Projects;Planarians;Positioning Attribute;Productivity;programs;Publishing;Regenerative Medicine;Research;Research Personnel;Research Support;Resources;Scientist;Senior Scientist;Services;System;Systems Development;Time;Training;trend;United States National Institutes of Health;Universities;Woman;Work;Zebrafish

PROJECT_TITLE: Expanding Excellence in Developmental Biology in Oklahoma


PROJECT_TERMS: Advisory Committees;Bioinformatics;Centers of Research Excellence;Communication;data sharing;Development;Developmental Biology;Effectiveness;Ensure;Foundations;Funding;Goals;Growth;Image;interdisciplinary approach;International;Medical Research;Mentors;Monitor;Oklahoma;Pathway interactions;Phase;Pilot Projects;Policies;programs;Research;Research Personnel;Resources;Technology;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Hypertensive disorders of pregnancy (HDP) are a leading contributor of maternal mortality in the US, and Black compared with White women are three to four times more likely to die from HDP. The proposed study addresses an urgent public health issue by investigating individual, interpersonal and neighborhood factors as contributors to the racial disparity in HDP. Results of this study will support the development of strategic interventions targeted to promote health equity and the improvement of birthing outcomes for Black women.

PI_NAMEs: DODDS, LEAH VERNA (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: Address;Adult;Age;American Heart Association;Behavior;Birth;Black race;black women;black/white disparity;Blood Glucose;blood lipid;Blood Pressure;Body mass index;built environment;Cardiometabolic Disease;cardiovascular risk factor;career;career development;Caring;Chronic;clinical training;Communities;community-level factor;Competence;Complex;Coronary Artery Risk Development in Young Adults Study;Data;Death Rate;design;Development;Diet;Discipline of obstetrics;disease disparity;Disparity;Disproportionately impacts women;Eclampsia;effective intervention;epidemiologic data;Epidemiology;Ethnic Population;Etiology;Grant;Gynecology;Health;Health behavior;health care service;Health Disparities Research;health disparity;health equity;health equity promotion;health inequalities;High Prevalence;Hypertension;improved;Incidence;Individual;Intervention;Knowledge;Life;Longitudinal, observational study;Maternal Health;maternal hypertension;maternal morbidity;Maternal Mortality;maternal outcome;Medical;Mental Health;Mentors;Modeling;mortality risk;Neighborhoods;nicotine exposure;Outcome;parous;perceived discrimination;Physical activity;physical conditioning;Physicians;population health;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Premature Birth;prepregnancy;Prospective, cohort study;psychological distress;Psychosocial Stress;Public Health;public health priorities;Race;racial discrimination;racial disparity;racial population;Racial Segregation;racism;Research;residential segregation;Risk Factors;Scientist;Secure;segregation;Sleep;sleep difficulty;social health determinants;Societal Factors;socioeconomic disadvantage;Structure;success;System;Training;United States;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Hypertensive Disorders of Pregnancy – The Black/White Disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  Vascular cognitive impairment and dementia (VCID) is the second most common cause of dementia after Alzheimer’s disease (AD), and development of effective therapies is urgently required. The object of this application is to investigate the key role of the Krüppel-like factor 11 in the regulation of long-term cognitive functions, brain white matter integrity, and neuronal loss in experimental VCID. The successful implementation of this proposal will elucidate the molecular mechanism of Krüppel-like factors-mediated vascular brain injury and may eventually lead us to discover novel Krüppel-like factors-based therapies for the treatment of VCID.

PI_NAMEs: YIN, KEJIE  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: acute stroke;Alzheimer's Disease;Attenuated;Binding Sites;Blood - brain barrier anatomy;Blood Preservation;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Cardiovascular system;Cell Differentiation process;cell growth;Cells;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Cerebrovascular Trauma;Cerebrum;Chronic;Cognition Disorders;Cognitive;cognitive function;Dementia;Development;Diabetes Mellitus;Diffuse;Economics;effective therapy;Endothelium;Extravasation;Family;Family member;Genetic;gray matter;hemodynamics;Immune;immune cell infiltrate;Impaired cognition;improved;Inflammation;Inflammatory Response;Injury;Intravenous;Investigation;Kruppel-like transcription factors;Lesion;Mediating;Mediator;member;migration;Molecular;mouse model;Mus;neuron loss;novel;old mice;Outcome;overexpression;Pathogenesis;Pathologic;Peripheral;Permeability;Play;preservation;prevent;Process;Promoter Regions;Proteins;Regulation;Reporting;Research;Role;social;Societies;therapeutically effective;Tight Junctions;Time;Transactivation;transcription factor;transcription factor KLF13;Transgenic Organisms;vascular cognitive impairment and dementia;vascular contributions;Vascular Endothelium;white matter;white matter injury;Zinc Fingers

PROJECT_TITLE: Targeting Kruppel-like Transcription Factor for White and Grey Matter Protection in Vascular Cognitive Impairment and Dementia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Aurora

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Insulin-producing beta cells in pancreatic islets are depleted in type 1 diabetes as a result of autoreactive T cell infiltration. My research will use submicron ultrasound contrast agents as tools to enhance the efficacy of peptide-based preventative therapeutics for type 1 diabetes; first as diagnostic agents to monitor therapeutic efficacy in presymptomatic type 1 diabetes and second as delivery vehicles for these therapeutics. This work will develop a novel diagnostic to monitor if therapeutic intervention is effective during presymptomatic type 1 diabetes and to enhance the repertoire of preventative therapeutic interventions for type 1 diabetes.

PI_NAMEs: CICCAGLIONE, MARK  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Affect;Age;American;Anti-Inflammatory Agents;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;Beta Cell;Blood Vessels;CD3 Antigens;Clinical;Clinical Trials;Cohort Studies;Complications of Diabetes Mellitus;Continuous Infusion;contrast enhanced;Contrast Media;Data;delivery vehicle;design;Development;Diabetes Mellitus;Diabetes prevention;Diabetic Ketoacidosis;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Progression;disorder prevention;Dose;Extravasation;Gases;Glucose;Goals;Hyperglycemia;Hypoglycemia;Image;Immune mediated destruction;Immune Tolerance;Immunologics;immunoregulation;Immunotherapy;Implantable Pump;implantation;improved;Infiltration;Inflammation;Infusion Pumps;innovation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Investigation;islet;Islets of Langerhans;Life;Measures;Microvascular Permeability;Monitor;Mus;nanobubble;novel;novel diagnostics;Operative Surgical Procedures;Pancreas;Patients;peptide drug;Peptides;Phase;preclinical study;Prediabetes syndrome;Predictive Factor;prevent;Quality of life;Regulatory T-Lymphocyte;Research;response;Risk;Route;Signal Transduction;Site;submicron;success;Symptoms;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted delivery;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Therapeutic Intervention;Tissues;tool;Traction;Treatment Efficacy;treatment response;Ultrasonography;ultrasound;uptake;vascular factor;Visualization;Work

PROJECT_TITLE: Submicron ultrasound contrast agents as diagnostic agents and therapeutic vehicles in type 1 diabetes


PI_NAMEs: GORBSKY, GARY J. (contact)

PROJECT_TERMS: Budgets;Centers of Research Excellence;Core Facility;Data;Developmental Biology;Disputes;Effectiveness;Goals;Image;Image Enhancement;imaging approach;imaging capabilities;imaging facilities;Imaging technology;Infrastructure;instrumentation;investigator training;Methods;Mission;Oklahoma;Phase;Pilot Projects;Research;Research Personnel;Strategic Planning;Training Programs

PROJECT_TITLE: Imaging Core


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Development of methods to prepare various medicinally active agents in a cost-effective, efficient, reliable and selective manner is vital to advances in human health care. The proposed research will produce unique, inexpensive and highly potent catalysts that promote efficient formation of some of the most ubiquitous units found in a large number of biologically significant molecules, but which cannot be accessed easily by other methods.

PI_NAMEs: WASA, MASAYUKI  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Catalytic and Stereoselective C-C-Heteroatom Bond Forming Reactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Sexual maturation and reproduction are regulated by environmental cues, but the precise nature of these cues remains largely unknown. We discovered two novel pheromones that trigger early puberty in female mice. This proposal analyzes the genetic and neural-circuit mechanisms used to detect and respond to these external cues.

PI_NAMEs: HOLY, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acceleration;Address;Adolescent;Alcohols;Animals;Behavior;behavioral response;Calcium;Carbon;cell type;Cells;Characteristics;Complex;Cues;Detection;Ectopic Expression;Environment;Enzymes;Estrus;Exhibits;experience;Female;Foundations;Future Generations;Genes;Genetic;Glucuronic Acids;Hydrocarbons;Image;Knock-in;Knockout Mice;Laboratories;Ligands;male;Mammals;Metabolic Pathway;mitral cell;multisensory;Mus;Natural Source;Nature;neural;neural circuit;Neurons;novel;Odors;Olfactory Pathways;open source;Output;Partner in relationship;Pattern;Pheromone;Physiology;Play;Pregnancy;Preparation;Production;Puberty;receptor;Receptor Gene;Reproducibility;Reproduction;Reproductive Behavior;response;Role;sensory integration;sensory system;Sexual Maturation;Sexual Reproduction;Signal Transduction;Smell Perception;social;Social Behavior;social organization;Stereotyping;Stimulus;Structure;synergism;System;Technology;Territoriality;Testing;tool;unpublished works;Urine;Viral;Volatilization;vomeronasal organ;Vomeronasal Systems;Work

PROJECT_TITLE: Identity and Neural Encoding of Social Odors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Despite the increasing incidence and prevalence of Inflammatory Bowel Diseases (IBD) in industrialized countries, our understanding of what causes these diseases remains unclear. Using microbial pathobionts cultivated from ulcerative colitis patients with ileal pouchitis and genetically prone murine models of experimental colitis, I will elucidate the role and relative contribution of the gut microbiota and host's immune responses in triggering and sustaining chronic inflammation in IBD-susceptible hosts.

PI_NAMEs: LAKE, JOASH  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Agreement;Anastomosis - action;anti-microbial peptide;Antibiotics;Anus;Bacteroides fragilis;Biological Markers;Cell Culture Techniques;Chronic;Clinical;Colectomy;Colitis;Colon;colon microbiota;Communities;Complex;conditioning;Critical Thinking;cytokine;Data;Developed Countries;Developing Countries;Development;Diet;Disease;Disease susceptibility;dysbiosis;Engraftment;Environment;Environmental Risk Factor;Event;Excision;Experimental Models;Flow Cytometry;Frequencies;Future;Gastrointestinal tract structure;Gene Expression;Gene Modified;Genes;Genetic;Genetic Predisposition to Disease;germ free condition;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;high risk;Human;human model;Ileal Reservoirs;Immune;immune activation;Immune response;immunogenic;immunogenicity;Immunology;improved;In Vitro;in vivo;Incidence;Indigenous;Industrialization;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;insight;Interleukin-10;Intestines;Knock-out;Knockout Mice;Knowledge;knowledge base;Large Intestine;lens;Life Style;Mentors;Metabolic Pathway;metabolomics;Metagenomics;Microbe;microbial;microbiome research;microbiota;Modeling;mouse model;Mucositis;Mucous Membrane;Mus;pathobiont;Pathogenesis;Pathway interactions;Patients;Play;potential biomarker;Pouchitis;Predisposition;Prevalence;Prevention strategy;Procedures;Production;Prospective Studies;Remission Induction;Research;Research Personnel;Ribosomal RNA;Risk;Risk Factors;risk prediction;Role;role model;Sampling;Science;Severities;skills;Spectrophotometry;stool sample;Testing;theories;Therapeutic;Training;transcriptome sequencing;Ulcerative Colitis;Volatile Fatty Acids;Wild Type Mouse

PROJECT_TITLE: Exploring the role and mechanisms of action of UC pouchitis-associated pathobionts (PAP) to gain insights into the etiopathogenesis of Inflammatory Bowel Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WREN, JONATHAN DANIEL (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Bioinformatics;Biological;Centers of Research Excellence;Chemicals;ChIP-seq;cohesion;Computer software;cost effective;Data;Data Analyses;data integration;Databases;Dedications;design;Development;Developmental Biology;differential expression;Disease;Doctor of Philosophy;Ensure;experience;experimental analysis;experimental study;FAIR principles;Fee-for-Service Plans;Feedback;Future;Gene Expression;Genes;Genomic Segment;Genomics;high throughput analysis;Human Resources;Image Analysis;improved;Institution;interest;Literature;machine learning method;Meta-Analysis;Methods;Modeling;Nature;Network-based;novel;novel strategies;Oklahoma;Participant;Pathway interactions;Peer Review;Phase;Phenotype;power analysis;Property;public database;Publications;Publishing;Research;Research Design;Research Personnel;Resources;Sample Size;Scientist;Services;skills;task analysis;Technology;tool;transcriptome sequencing;Troglodytinae

PROJECT_TITLE: Bioinformatics and Pathways Core


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer for which there are limited treatment options. This study will employ a novel mouse model of the disease and state-of-the-art technologies to elucidate the role of tumor-associated neutrophils in squamous lung cancer development, progression and therapeutic response. This work is relevant to public health and the NIH mission because it will increase our understanding of how the innate immune system impacts cancer and may ultimately suggest new therapeutic strategies that can improve the quality of life and survival of lung cancer patients.

PI_NAMEs: OLIVER, TRUDY GALE (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 3-Dimensional;Ablation;Adenocarcinoma;Adenocarcinoma Cell;angiogenesis;anti-PD1 antibodies;Antibodies;Architecture;Biological Markers;Cancer Biology;cancer cell;cancer diagnosis;Cancer Patient;cancer therapy;Cell Culture Techniques;Cell Physiology;cell type;Cells;Cessation of life;Chemotaxis;chemotherapy;Clinical Trials;clinically relevant;combat;Complex;Coupled;CTLA4 gene;Data;Desmoplastic;Development;Diagnosis;Disease;disease model;DNA Sequence Alteration;effective therapy;extracellular;Genetic;genetic approach;Genetically Engineered Mouse;Goals;Histology;Histopathology;Human;human disease;IL8RB gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunocompetent;Immunotherapy;improved;inhibitor;Innate Immune System;innovation;keratinization;Laboratories;Light;Lung Neoplasms;Lymphocyte;Malignant Epithelial Cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;Mission;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Neoplasm Metastasis;neoplastic cell;neutrophil;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Organism;Outcome;patient subsets;Patient-Focused Outcomes;Persons;pharmacologic;Play;Production;Prognosis;programmed cell death protein 1;Proliferating;Public Health;Quality of life;Reactive Oxygen Species;Research;Resistance;response;Role;Shapes;single-cell RNA sequencing;small molecule;Squamous Cell;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;Survival Rate;Technology;Testing;Therapeutic;tool;transdifferentiation;treatment response;treatment strategy;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;tumor-immune system interactions;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Pro-tumor functions of neutrophils in squamous cell lung cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Congenital conditions that alter the structure of the skull including craniosynostosis are among the most common of birth defects. Treatment for these disorders largely relies on invasive and, often, multiple surgeries beginning in infancy. By studying the disease mechanisms that disrupt skull development in Bent Bone Dysplasia Syndrome, this proposal will advance our potential to develop novel molecular-based therapeutics for its treatment.

PI_NAMEs: NICKLE, AUDREY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Alleles;Animal Model;ATAC-seq;Atlases;Binding;Birth;bone;Calvaria;Cell Lineage;Cell membrane;Cell Nucleus;Cells;ChIP-seq;Chromatin;chromatin remodeling;Congenital Abnormality;Connective Tissue Cells;coronal suture;craniofacial;Craniosynostosis;cranium;Cultured Cells;Data;Data Set;Dense Connective Tissue;Development;Developmental Bone Diseases;differential expression;Disease;disease mechanisms study;Dura Mater;Embryo;Enhancers;Equilibrium;Fibroblast Growth Factor Receptor 2;Fibroblasts;Frontal bone structure;Gene Expression;Gene Expression Regulation;gene repression;Gene Targeting;Genes;Genetic;Genomics;Histologic;Immunofluorescence Immunologic;in silico;In Situ Hybridization;In Vitro;Individual;inducible Cre;infancy;Joints;Knock-in;Knowledge;Legal patent;Ligaments;Maintenance;Mediating;member;Membrane;Mesoderm;Missense Mutation;Molecular;mouse model;Mus;mutant;Mutation;Neural Crest Cell;novel;Nuclear;Operative Surgical Procedures;Osteoblasts;Osteogenesis;osteogenic;p53 Signaling Pathway;Pathogenesis;Pathway interactions;Pattern;Periosteum;Phenotype;Play;Population;postnatal;premature;Prevalence;prevent;progenitor;promoter;Regulation;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;skeletal disorder;stem cells;Structure;Surgical sutures;Symptoms;Syndrome;Testing;Therapeutic;tissue stem cells;TP53 gene;transcriptome sequencing;Variant;WNT Signaling Pathway

PROJECT_TITLE: Mechanisms of Craniosynostosis in Bent Bone Dysplasia Syndrome

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: 8. Project Narrative This T32-funded Training Program enhances institutional training in cellular, biochemical and molecular biology by providing students with advanced instruction in critical thinking, ensuring scientific rigor and reproducibility in experimental approaches, exposure to cutting edge techniques, and training in professionalism and other skills necessary for using their PhD degrees in a wide variety of career paths. Our training program leverages outstanding research programs in mentor labs in areas related to the complicated biology of DNA, RNA and proteins and their relationship to various diseases.

PI_NAMEs: HAYES, JEFFREY J;MAQUAT, LYNNE E (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Biochemical;Molecular;Science;Training

PROJECT_TITLE: Training in Cellular, Biochemical and Molecular Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Our proposed work will identify new biological factors in breast cancer disparities, develop effective antibody- drug conjugate targeted therapy for patients with triple negative breast cancer, especially African American patients, and elucidate the regulatory mechanism underlying differential expressions in breast cancer disparities.

PI_NAMEs: LIU, RUNHUA RUNA (contact);LIU, XIAOGUANG MARGARET;WANG, LIZHONG

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 4T1;Address;African American;African American Women;aggressive breast cancer;American;Animal Model;anti-cancer;Antibody-drug conjugates;antitumor effect;Automobile Driving;Basic Science;Behavior;Biodistribution;Bioinformatics;Biological;Biological Factors;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Breast Epithelial Cells;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer subtypes;candidate identification;caucasian American;Cell Line;Cell membrane;Cell surface;Cell Surface Proteins;chemotherapy;Clinical;comparative;curative treatments;cytotoxic;cytotoxicity;Data Set;Death Rate;design;Diagnosis;differential expression;Disparity;Distant;dosage;Dose;Drug Kinetics;Drug Modelings;early onset;effective therapy;Endocytosis;epidemiology study;Epigenetic Process;ERBB2 gene;Evaluation;experimental study;Extracellular Domain;Fc Receptor;gemcitabine;Genetic;Goals;Growth;High Prevalence;Human;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Investigation;lipid metabolism;Lipids;Lipolysis;Lipoprotein Receptor;Lipoproteins;Malignant - descriptor;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Maximum Tolerated Dose;Mediating;Membrane;Membrane Proteins;Messenger RNA;Methods;Monoclonal Antibodies;mouse model;Nature;neoplastic cell;new therapeutic target;Non-Malignant;Normal tissue morphology;novel therapeutic intervention;Operative Surgical Procedures;Outcome;overexpression;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;Play;pre-clinical;Pre-Clinical Model;Procedures;Production;protein expression;Proteomics;Protocols documentation;Quality of life;Race;racial disparity;receptor;receptor expression;Role;Safety;Sampling;side effect;small molecule;Societal Factors;Specificity;Stains;Surface;Survival Rate;synergism;systemic toxicity;targeted cancer therapy;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Tight Junctions;Time;Tissue Sample;Tissues;Toxic effect;translational applications;translational therapeutics;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor stage;uptake;Woman;Women's mortality;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Identifying a New Biological Target for Breast Cancer Therapy That Contributes to Disparities for African-American Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Z(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Youth experiencing homelessness (YEH) are disproportionately affected by HIV compared to their stably housed peers. However, little is known about the unique risks faced by YEH who are precariously housed (i.e., “couch-surfing” or temporarily staying with others). The proposed study will examine how the social support networks and living situations of precariously housed YEH impact their HIV risk and prevention behaviors.

PI_NAMEs: PETRY, LAURA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Affect;Age;AIDS prevention;Appointment;Attention;Awareness;Behavior;California;career;Cessation of life;Characteristics;Child Abuse;child neglect;children of color;Conceptions;condoms;Contracts;Data;Data Set;Development;Educational Intervention;ethnic minority status;experience;Family;family support;Friends;Goals;Health;Hearing;Heterogeneity;high risk population;high risk sexual behavior;HIV;HIV risk;Homeless persons;Homeless Youth;Homelessness;Household;Housing;Human immunodeficiency virus test;injection drug use;Internet;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Literature;Longitudinal Studies;Los Angeles;Mental Depression;Mental Health;Methodology;Methods;Needle Sharing;Pathway Analysis;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Population;pre-exposure prophylaxis;Prevalence;Prevention;preventive intervention;racial minority;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Behaviors;Risk Taking;Role;Safety;Sample Size;Science;sex;Sexual Partners;skills;Social Environment;Social Interaction;Social Network;social relationships;Social support;Statistical Methods;Subgroup;Substance abuse problem;substance use;supported housing;Surveys;Training;transactional sex;transmission process;Unsafe Sex;Victimization;Vulnerable Populations;Work;Youth

PROJECT_TITLE: HIV risk and prevention behavior and the role of social support networks among precariously housed youth: A mixed-methods study


PI_NAMEs: DAWSON, DEAN S (contact)

PROJECT_TERMS: Advisory Committees;Award;Bioinformatics;career;career development;Centers of Research Excellence;Developmental Biology;Eligibility Determination;Ethics;faculty mentor;Feedback;Funding;Future;Grant;Human Resources;Image;Infrastructure;Mentors;Monitor;Oklahoma;Phase;Pilot Projects;Process;Program Research Project Grants;programs;Protocols documentation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Science;Selection Criteria;Work

PROJECT_TITLE: Pilot Projects Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: We recently identified histone lysine lactylation as a new type of PTM that is derived from and can be stimulated by lactate, the Warburg effect-associated metabolite. The goals of this project are to identify this pathway's regulatory elements and to investigate their epigenetic roles during hair cycle. The results from this study will significantly advance our understanding of epigenetic mechanism, and reveal functions of lactate that are associated with diverse physiological and pathological changes, including but not limited to hair cycle.

PI_NAMEs: LIN, HENING ;ZHAO, YINGMING  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acetylation;Acetyltransferase;adult stem cell;Area;Behavior;Biochemical;Biochemistry;Bioinformatics;Biology;Cell Physiology;Cells;Chemicals;Chemistry;ChIP-seq;Chromatin;chromatin immunoprecipitation;Coenzyme A;Cultured Cells;Data;Data Set;Deacetylase;deep sequencing;Diabetes Mellitus;Disease;DNA;Energy Metabolism;Environment;Enzymatic Biochemistry;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;experimental study;Foundations;Gene Expression Regulation;Genes;Goals;Growth;Hair;Hair follicle structure;Histone Deacetylase;Histones;Human;Hypoxia;Immune response;Infrastructure;insight;knock-down;Knock-out;Knowledge;Laboratories;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolism;Methylation;Modification;Molecular;Mus;overexpression;Pathologic;Pathway interactions;Periodicity;Phase;Physiological;Physiology;Play;Positioning Attribute;Post-Translational Protein Processing;programs;Proteins;Proteomics;Reaction;Regulatory Element;Regulatory Pathway;Research;response;Resting Phase;Role;Site;Skin;stem cell differentiation;stem cells;Substrate Specificity;System;Testing;Tissues;Transcriptional Regulation;transcriptome sequencing;Warburg Effect;Western Blotting

PROJECT_TITLE: Histone lactylation pathway in hair cycle: deacylases and their protein targets

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This new application for five years support is to provide advanced training to predoctoral and postdoctoral fellows in translational research in Alzheimer's disease and related dementias. The aging of the US population means a continued need for new investigators trained in the study of the age-associated brain diseases, especially dementia disorders, with a focus on the latest technologies and scientific approaches. This Training Program uses a multi-disciplinary approach through didactic instructions, courses, seminars, talks, and advisory groups to prepare the trainees for research careers in focused on Alzheimer's disease and related dementias.

PI_NAMEs: BREWER, JAMES B (contact)

PROJECT_TITLE: Multidisciplinary training in basic and translational Alzheimer's disease research

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The mission of the Neuroscience Training Program (NTP) at Johns Hopkins University is to provide students with instruction in the neurosciences at the beginning of their graduate career to enable them to contribute to the advancement of scientific knowledge and improve human health through diverse careers. By serving as focal point for faculty, students and fellows conducting neuroscience research at Johns Hopkins, the program enhances collaborations that lead to a greater understanding of the role of the nervous system in health and disease.

PI_NAMEs: KNIERIM, JAMES J (contact);POTTER, CHRISTOPHER JOHN

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Training Program in Neuroscience


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE In recent years, there has been an increase in the prevalence of Type 1 Diabetes (T1D), and yet we still do not understand the mechanisms that lead to β-cell dysfunction and destruction in disease pathogenesis. The goal of this project is to provide comprehensive training and career development opportunities to Ms. Wagner as she works to understand the role of heterogenous β-cell reactive oxygen species (ROS) presence in disease development and determine the molecular signature behind this observed heterogeneity. The aim of this project is to address the gap in our knowledge of intrinsic mechanisms of β-cell dysfunction and has the potential to spark the development of novel therapeutics to treat and prevent T1D.

PI_NAMEs: WAGNER, LESLIE ELAINE (contact)

PROJECT_TERMS: Acute;Address;Advisory Committees;ANXA5 gene;Apoptosis;Apoptotic;Area;Autoimmune Diseases;Autoimmune Responses;Award;Beta Cell;Biosensor;career development;Cells;Communication;Comprehension;Coupled;cytokine;Cytoplasm;design;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;diabetogenic;differential expression;dihydroethidium;Disease;Disease Progression;disorder prevention;early childhood;early onset;Endoplasmic Reticulum;endoplasmic reticulum stress;Enterovirus;Environment;Event;experimental study;Fluorescence-Activated Cell Sorting;Functional disorder;Funding;Future;Gene Expression;Genes;Genetic Predisposition to Disease;Genetic Risk;Goals;Grant;Heterogeneity;Human;Hydrogen Peroxide;Immune;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Indiana;Individual;Induction of Apoptosis;Inflammatory;Innate Immune System;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interferon alpha;Interferons;Interleukin-1 beta;intravital imaging;islet;Islets of Langerhans;Knowledge;Label;Laboratories;Link;medical schools;Metabolic Diseases;MHC Class I Genes;Microscopy;Mind;Mitochondria;Molecular Profiling;Monitor;mouse model;Mus;Nitric Oxide;non-diabetic;novel;novel therapeutics;Oral;Oranges;Organelles;overexpression;Oxidative Stress;Oxidative Stress Induction;Pancreas;Pathogenesis;Patients;Population;Predisposition;Prevalence;prevent;Production;Proteins;Publishing;ratiometric;Reactive Oxygen Species;Research;Research Personnel;Residual state;response;Risk;Role;Scientist;single-cell RNA sequencing;Slice;Stress;stressor;Superoxides;Techniques;Testing;Therapeutic;therapeutic target;Training;transcriptomics;United States National Institutes of Health;Universities;Virus Diseases;Work;Writing

PROJECT_TITLE: Beta Cell Heterogeneity in the Interferon Alpha Response


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Overall goal of this project is to create a paradigm shifting diagnosis and patient management strategy (called  HIT-PIRADS) for prostate cancer (PCa) that will significantly increase PPV for clinically significant PCa detection  while minimizing unnecessary prostate biopsies and related morbidities. Due to its interpretable nature and bias correction paradigm, our AI system will generate predictions that physicians can trust. One of the immediate  outcomes of the system will be a reproducible risk scoring system that can be used in community hospitals and  locales without MRI-subspeciality genitourinary trained radiologists to improve the accuracy of prostate imaging  nationwide. In the long term, we expect HIT-PIRADS to be widely adopted in clinics and trigger other treatment  & prevention strategies to be developed based on HIT-PIRADS.

PI_NAMEs: BAGCI, ULAS  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Adopted;Adoption;Age;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Artificial Intelligence platform;Benchmarking;Biopsy;cancer classification;Cancer Detection;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancerous;capsule;Cessation of life;Classification;classification algorithm;Clinic;Clinical;clinical imaging;clinically significant;cohort;Community Hospitals;Dangerousness;Data;data acquisition;data curation;Data Reporting;Data Set;Demography;design;Detection;Diagnosis;digital;Effectiveness;efficacy validation;Evaluation;experience;Expert Systems;explainable artificial intelligence;Family Cancer History;Genitourinary system;Goals;Guidelines;high risk;Histology;Hybrids;Image;improved;Incidence;Information Systems;innovation;Intelligence;International;Joints;Laboratories;Lesion;Locales;Machine Learning;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;men;Metadata;Minority Groups;Morbidity - disease rate;Morphologic artifacts;mortality;MRI Scans;multi-task learning;Nature;neural network algorithm;Noise;novel;Operative Surgical Procedures;Outcome;Patients;Physicians;Population Heterogeneity;Predictive Value;Prevention strategy;prospective;Prostate;prostate biopsy;Race;radiological imaging;radiologist;Radiology Specialty;Reader;Recommendation;Rectum;Reporting;Reproducibility;Reproducibility of Results;Research;Risk;risk stratification;Role;Scanning;Screening for Prostate Cancer;serum PSA;Source;Standardization;System;tool;Training;treatment strategy;Trust;trustworthiness;Uncertainty;United States National Institutes of Health;Universities;Variant;Visual

PROJECT_TITLE: Hybrid Intelligence for Trustable Diagnosis And Patient Management of Prostate Cancer (HIT-PIRADS)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Microbiome

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Type 2 diabetes is a growing health concern, with increasing incidence globally, that occurs due to a combination of genetic and environmental factors. RoundUp is the most widely applied herbicide, and glyphosate, the active ingredient, alters the mammalian gut microbiome, which can impact metabolic disease development. This research project will investigate impact of glyphosate on glucose regulation, identifying gut bacteria and signaling pathways that can be targeted to prevent the effects of glyphosate on diabetes development.

PI_NAMEs: MEYER, RACHEL  (contact)

PROJECT_TERMS: Acute;Agonist;Agriculture;Antibiotics;Arizona;Bacteria;Bile Acids;blood glucose regulation;Child;Chronic;Collaborations;Coupled;Data;Development;Diabetes Mellitus;Diagnosis;Dose;drinking water;dysbiosis;Environment;Environmental Risk Factor;Enzymes;Etiology;experience;Exposure to;Fellowship;Female;Functional disorder;Genetic;Germ-Free;glucagon-like peptide 1;Glucose Intolerance;glucose tolerance;glyphosate;Gnotobiotic;Goals;GPBAR1 gene;GTP-Binding Proteins;gut bacteria;gut microbiome;gut microbiota;Health;Herbicides;Homeostasis;Human;impaired glucose tolerance;Impairment;improved;Incidence;Insecticides;insight;Insulin Resistance;Intake;Intestines;Knockout Mice;Knowledge;Lithocholic Acid;Liver;Maintenance;male;Mammalian Cell;Mammals;Mediating;Metabolic Biotransformation;Metabolic Diseases;Metabolism;metabolome;metagenomic sequencing;Metagenomics;microbiome;Modification;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;oral glucose tolerance;Pathway interactions;Peptides;Pharmacology and Toxicology;Plants;Play;Population;Prevalence;prevent;Production;proglucagon;receptor;Receptor Signaling;Research;Research Personnel;Research Project Grants;Role;Roundup;Scientist;shikimate;Shotguns;Signal Pathway;Signal Transduction;Signaling Molecule;Small Intestines;symposium;Testing;Training;Transgenic Mice;United States;Universities

PROJECT_TITLE: Glyphosate impairs glucose homeostasis via gut microbiome induced alterations to bile acid signaling


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE Although anxiety disorders are a major public health burden, existing treatments are only moderately effective, highlighting the need to identify and further investigate malleable risk factors for anxiety. Intolerance of uncertainty (IU) is one risk factor that may be critical to the development of anxiety, however research on IU is limited from both a conceptual and measurement perspective, raising questions about the predictive utility of IU. This study has the potential to provide a better understanding of how IU contributes to risk for anxiety by clarifying the measurement of IU and by exploring how IU affects maladaptive responses in daily life.

PI_NAMEs: BROOS, HANNAH CLAIRE (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adult;Affect;Affective;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;avoidance behavior;Behavior;behavior measurement;Behavioral;Behavioral Model;behavioral response;Clinical;Clinical assessments;Clinical Research;comorbidity;Computer Models;cost;Data;Decision Making;design;Development;Diagnostic;diagnostic criteria;Distress;Divorce;Ecological momentary assessment;economic cost;effective therapy;experience;Fellowship;Functional impairment;Goals;improved;Individual;Individual Differences;innovation;Intervention;Investigation;Life;Link;Literature;Longitudinal Studies;Maintenance;Measurement;Measures;Mediating;meetings;Methodology;Methods;modifiable risk;multimodality;National Institute of Mental Health;negative affect;negative mood;novel;Pathology;Patient Self-Report;Persons;Population;prevent;Prevention;psychologic;Public Health;Quality of life;Research;Research Design;Research Domain Criteria;Research Personnel;response;Risk;Risk Estimate;Risk Factors;Sampling;Techniques;Time;Training;treatment of anxiety disorders;Uncertainty;virtual

PROJECT_TITLE: An Ecological Momentary Assessment Study of Intolerance of Uncertainty: Linking Computational Measures with Clinical Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Genetics;Human Genome

PHR: Project Narrative Chromatin mediated regulation of the genome is critical in human development and health, and dysregulation of chromatin remodeling processes is associated with a large number human pathologies including developmental disorders, cardiovascular disease, cancer, auto-immune disease, and neurological and psychiatric disorders. This proposal seeks to determine mechanisms of chromatin structure regulation by defining the molecular details underlying how regulatory complexes navigate chromatin. Results will provide significant insight into processes of genome regulation, the etiology of human disease, and lay the groundwork for the development of targeted therapeutics.

PI_NAMEs: MUSSELMAN, CATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Autoimmune Diseases;Biochemistry;Biology;Cardiovascular Diseases;Cell Nucleus;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Complex;Cryoelectron Microscopy;Cues;Development;developmental disease;DNA;DNA Sequence;epigenomics;Etiology;Fluorescence Microscopy;Gene Expression Regulation;genetic information;Genetic Transcription;Genome;Goals;Health;histone modification;Histones;Human Development;human disease;Human Genome;Human Pathology;insight;Instruction;interdisciplinary approach;Investigation;Kinetics;Malignant Neoplasms;Mediating;Mental disorders;model building;Molecular;Molecular Conformation;Mutation;Nervous System Disorder;NMR Spectroscopy;Nucleosomes;Pattern;Post-Translational Protein Processing;PRC1 Protein;Process;programs;Proteins;Reader;Regulation;Research;response;Signal Transduction;Specificity;targeted treatment

PROJECT_TITLE: Molecular mechanisms of histone signaling in a chromatin relevant context


ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: The diagnosis and treatment of disease increasingly relies on a detailed molecular understanding of the underlying conditions and the ability to intervene with chemical precision. The Chemistry-Biology Interface training program at Cornell University unites a diverse group of chemists and biologists to produce a diverse set of future researchers that are capable of rigorously addressing the most pressing biomedical challenges at the molecular level, and to prepare them for diverse career paths.

PI_NAMEs: BASKIN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemistry;Future;Training

PROJECT_TITLE: Training future leaders at the chemistry-biology interface

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Bone marrow failure involves defects in fundamental processes of cells, and some of these are cancer predisposition syndromes. These diseases highlight basic mechanisms underlying cellular behavior, such as DNA damage repair, chromosome maintenance, or protein production. This application studies the contribution of EIF6 in Shwachman-Diamond syndrome, a disorder that affects ribosomes that make proteins.

PI_NAMEs: COREY, SETH JOEL (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Ablation;Address;Adult;Affect;Alleles;Amino Acids;Atrophic;autosome;Biochemical;biological adaptation to stress;Biology;Blood;Bone marrow failure;bone marrow failure syndrome;cancer predisposition;cell behavior;Cell Death;Cell Line;Cell Nucleolus;Cell Physiology;Cells;Childhood;chromosome 20q loss;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Cytoplasm;Defect;Disease;Dissection;DNA Repair;Embryo;Eukaryotic Cell;Exocrine pancreatic insufficiency;Experimental Designs;Fertilization;Fishes;Functional disorder;G6PC3 gene;Generations;Genes;Genetic;genetic analysis;Germ Lines;Goals;Growth;Health;Hematopoiesis;Human;Human Cell Line;human disease;improved;innovation;Investigation;Knock-out;Knowledge;Lead;lipid metabolism;Maintenance;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Methods;model organism;Modeling;Molecular;Mus;mutant;Mutate;Mutation;Myelogenous;Neoplasms;Neutropenia;neutrophil;novel;novel therapeutics;Nutrient;Orthologous Gene;Pancreas;Pathogenesis;Pathway interactions;Patients;Phenocopy;Phenotype;Polyribosomes;pressure;Process;Production;Protein Biosynthesis;protein metabolism;Proteins;prototype;Quality of life;Recommendation;recruit;response;Ribosomes;ribosomopathy;Risk;RNA;Shwachman-Diamond syndrome;skeletal dysplasia;Somatic Mutation;Stress;Survival Rate;Syndrome;Text;Tissues;TP53 gene;Translating;Validation;Western Blotting;Zebrafish

PROJECT_TITLE: Genetic Dissection of Stress Responses in Shwachman-Diamond Syndrome

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE Understanding the complex molecular basis of normal physiology and the disruption of these processes in disease requires broad knowledge of biochemistry, cell and molecular biology and the ability to integrate these components to gain new insight. Our training program provides students with this cross-disciplinary training and opportunities to apply this knowledge to significant questions of relevance to human health. !

PI_NAMEs: CAPALDI, ANDREW PAUL (contact);TAX, FRANS E

PROJECT_TERMS: Biochemistry;Molecular Biology;Training

PROJECT_TITLE: Graduate Training in Biochemistry and Molecular Biology


NIH_SPENDING_CATS: Aging

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PHR: NARRATIVE  Aging and diseases associated with age clearly result in dependence and a severe reduction in health-span; however, without a clear understanding of the interactions between aging and disease, effective therapies cannot be developed. Our training program in GeroScience was initiated in 2017 to fill this void and train the next generation of researchers to address the complex causes of aging and their interactions with age-related disease. Based on our outstanding success, current census and plans for continued expansion of our program, we have increased our mentoring faculty to 21 and are requesting one additional position to continue our training program.

PI_NAMEs: MILLER, BENJAMIN FRANCIS;SONNTAG, WILLIAM EDMUND (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Geroscience;Oklahoma;Training Programs

PROJECT_TITLE: GEROSCIENCE TRAINING PROGRAM IN OKLAHOMA


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative This project is aimed at understanding the structure and function of a large number of helical protein and nucleoprotein filaments, ranging from actin in human muscle to helical viruses that infect organisms living in nearly boiling acid. Some of the studies are likely to have a direct and immediate impact on human health, such as those involving the bacteria responsible for meningitis and food poisoning, while others will have longer range impact including new tools for biotechnology.

PI_NAMEs: EGELMAN, EDWARD H. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Narrative We have generated recombinant derivatives of the existing TB vaccine, Bacillus Calmette-Guérin (BCG), that express human cytokines targeting B cells to complement chemotherapy and improve suboptimal tuberculosis (TB) control. Our proposal will determine the safety, immunogenicity, prophylactic efficacy and therapeutic efficacy of these recombinant BCG vaccines and their robustness towards host/pathogen genetics, drug resistance and, in principle, their feasibility in TB and TB/HIV patients on therapy. This will establish whether B cells can be harnessed for next generation TB vaccine development.

PI_NAMEs: GENGENBACHER, MARTIN ALFONS (contact);WILKINSON, ROBERT JOHN

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: adaptive immunity;Adult;Animal Model;Animals;antiretroviral therapy;Area;Attenuated Vaccines;B-Cell Activation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;BCG Live;BCG Vaccine;Blood;Cell secretion;Cells;chemotherapy;Child;Childhood;Circulation;Clinical;co-infection;cohort;Combination Drug Therapy;Complement;Containment;cytokine;Data;Development;Drug resistance;experimental study;Exposure to;Face;Flow Cytometry;Frequencies;Genes;Genetic;Genetic Engineering;genetic resistance;HIV;HIV therapy;HIV/TB;Human;humoral immunity deficiency;Immunodeficient Mouse;immunogenic;immunogenicity;Immunologics;Immunophenotyping;immunoregulation;improved;Individual;infected B cell;Infection;Infection prevention;Inhibition of Apoptosis;inhibition of autophagy;innovation;knock-down;Ligands;Longevity;Lung;Macrophage;Measures;Memory;Modeling;Monitor;mouse model;Mus;mutant;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;next generation;novel;Organ;pathogen;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Pre-Clinical Model;prevent;Proliferating;prophylactic;protective efficacy;rBCG;reactivation from latency;receptor;Recombinants;Recurrence;Regimen;Relapse;relapse prevention;Research;response;Role;Route;Safety;safety assessment;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic vaccine;Time;Treatment Efficacy;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;Vaccine Research;Vaccines;Virus Diseases

PROJECT_TITLE: Harnessing B cells for TB vaccine development to improve therapy of TB and TB-HIV coinfection


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: NARRATIVE . High-resolution tools for assessing retinal structure and function are central to advancing our understanding of the limits of human vision in health and disease as well improving our ability to develop and evaluate novel therapeutic strategies for patients with vision loss. Using advanced retinal imaging tools, this proposal aims to evaluate therapeutic potential in blue cone monochromacy, quantify the relationship between disruptions in the photoreceptor mosaic and visual resolution, and examine the impact of premature birth on retinal structure and function. Our proposal addresses many research needs, gaps, and opportunities outlined in the 2021-2025 NEI Strategic Plan, “Vision for the Future”.

PI_NAMEs: CARROLL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Abbreviations;accurate diagnosis;achromatopsia;adaptive optics;Address;Affect;Algorithms;Anatomy;Angiography;Animal Model;Assessment tool;Behavior;Biological;Biological Markers;Blindness;blue cone monochromacy;Cells;Classification;Clinical;clinical phenotype;Clinical Trials;Code;Cone;Contrast Sensitivity;Defect;Deterioration;Devices;Disease;disease diagnosis;Documentation;Evaluation;Foundations;fovea centralis;Future;gene therapy;Genetic;Goals;Grant;Health;high resolution imaging;Human;Imaging Device;imaging modality;Impairment;improved;Incentives;Individual;individualized medicine;Inherited;inherited retinal degeneration;innovation;insight;Interdisciplinary Study;Light;Link;Literature;Locus Control Region;Measurement;Measures;Mediating;mosaic;novel therapeutic intervention;novel therapeutics;Nuclear;Ophthalmoscopy;Optical Coherence Tomography;Outcome;Outcome Measure;Pathology;Patients;Photoreceptors;Population;Positioning Attribute;Practice Guidelines;premature;Premature Birth;Privatization;programs;Psychophysics;Published Comment;Recording of previous events;Refractive Errors;Research;Resolution;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;Retinitis Pigmentosa;risk prediction;Rod;sample fixation;Scanning;Standardization;Strabismus;Strategic Planning;Structure;Structure-Activity Relationship;success;Systemic disease;Techniques;Technology;Testing;Theoretical model;Therapeutic;Time;tool;Treatment Efficacy;Validation;Vision;Visual;Visual Acuity;Visual Cortex;visual processing;Work

PROJECT_TITLE: Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE This research will contribute fundamental knowledge about how the primate brain represents dynamic aspects of the three-dimensional (3D) world. In the short term, it will reveal how ecologically relevant representations of the world are created from ambiguous sensory information and in the long term provide insights for treating neurological disorders, brain injury, and cognitive dysfunction. Because 3D vision is a major component of virtual and augmented reality (VR/AR), the public health relevance of this work extends to industry which faces growing demands to develop devices that are safe, persuasive, inclusive, and of therapeutic utility.

PI_NAMEs: ROSENBERG, ARI  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;3D world;Anesthesia procedures;Area;area MST;area MT;Behavior;behavior prediction;Behavioral;Brain;Brain Injuries;Child;computer studies;Cues;Data;density;Devices;dimension reduction;Discrimination;discrimination task;electrical microstimulation;Electrophysiology (science);Event;experimental study;Eye;Face;Fundus;Future;Glean;Goals;Heterogeneity;Impaired cognition;indexing;Individual;Industry;insight;Intercept;Knowledge;Lateral;Left;Linear Regressions;Macaca;Measures;Medial;Methods;Modeling;Monkeys;Motion;Motion Perception;Movement;movie;Nervous System Disorder;neural;neural network;Neurons;novel;object motion;optic flow;Output;Pattern;Perception;preference;Preparation;Primates;Probability;Property;public health relevance;Reporting;Research;response;Retina;Running;sample fixation;Sensory;Signal Transduction;Site;stereoscopic;Stimulus;Structure of superior temporal sulcus;support network;Testing;Therapeutic;Translations;two-dimensional;Virtual and Augmented reality;Vision;Visual;Visual System;Work

PROJECT_TITLE: Cortical processing of three-dimensional object-motion

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Heart Disease;Infectious Diseases;Nutrition;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project narrative  Chagas disease, caused by Trypanosoma cruzi parasites, is an important cause of heart failure with no effective treatment in late-stage disease. This project will build on our findings that L-carnitine treatment improves chronic Trypanosoma cruzi infection severity, to determine the mechanism of action of L-carnitine in chronic Chagas disease treatment. This project is relevant to the NIH’s mission because results will guide L- carnitine pre-clinical and clinical development, identify new avenues for Chagas disease patient treatment, and expand our understanding of Chagas disease pathogenesis.

PI_NAMEs: MCCALL, LAURA-ISOBEL  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;acylcarnitine;Address;Adverse effects;Affect;alternative treatment;American;Amino Acids;Antiparasitic Agents;bench-to-bedside translation;Benznidazole;Biological Assay;Biological Markers;Brain natriuretic peptide;Carbohydrates;Cardiac;Cardiac health;Cardiology;Carnitine;Cell Respiration;Chagas Disease;Chronic;chronic infection;Clinic;Clinical;clinical care;clinical development;clinical implementation;clinical translation;Complementary therapies;cost;Data;Development;Disease;disease model;drug development;Echocardiography;effective therapy;Esters;Experimental Models;fatty acid metabolism;fatty acid oxidation;Fatty Acids;FDA approved;Funding;Generations;Glucose;glucose metabolism;Goals;Healthcare;Heart;heart damage;Heart Diseases;Heart failure;heart function;heart metabolism;Heart Transplantation;Impairment;improved;In Vitro;in vivo;Individual;Infection;innovation;insight;Knowledge;Laboratories;Lesion;Levocarnitine;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;metabolomics;Mission;Mitochondria;mortality;Mus;Myocardial;novel;Outcome;oxidation;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;preclinical development;Prevalence;prevent;protective effect;Publishing;pyruvate dehydrogenase;Research;Research Priority;Role;Safety;Severities;Severity of illness;Site;Societies;standard of care;Structure;Symptoms;Testing;Therapeutic;Tissues;treatment duration;Treatment Protocols;treatment strategy;Trypanosoma cruzi;United States;United States National Institutes of Health;vaccine access;Work;World Health Organization

PROJECT_TITLE: Deciphering the mechanism of action of carnitine, a novel treatment for chronic Chagas disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(83)]