NIH_SPENDING_CATS: Autoimmune Disease;Burden of Illness;Clinical Research;Diabetes;Digestive Diseases;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The development of diabetes mellitus following an episode of acute pancreatitis (termed AP- related DM) is now recognized in approximately 25% of patients; however, its epidemiology and pathophysiology remain poorly characterized. The Ohio State University Clinical Center (OSU- CC) has developed a prospective, longitudinal, observational cohort study in AP, along with a series of hypothesis-driven investigations to address knowledge gaps in AP-related DM.

PI_NAMEs: CONWELL, DARWIN LEWIS;HART, PHILIP A.;PAPACHRISTOU, GEORGIOS I (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Accounting;Acinar Cell;Acute;Acute Necrotizing Pancreatitis;acute pancreatitis;Address;Admission activity;Adult;Autoimmune;biobank;Biological;Biological Markers;blood glucose regulation;Body Weight;burden of illness;Cell Physiology;Clinical;clinical center;clinical diagnosis;clinical predictors;Code;cohort;comparison control;Complication;Data Set;design;Development;Diabetes Mellitus;Diagnostic;diagnostic biomarker;diagnostic development;Disease;Elastases;Endocrine;Enrollment;epidemiologic data;Epidemiology;Exhibits;Exocrine pancreas;Exocrine pancreatic insufficiency;Fat-Soluble Vitamin;Feces;follow-up;Frequencies;Functional disorder;Future;Goals;Hospitalization;improved;Incidence;incretin hormone;Inflammatory;innovation;Insulin;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Islet Cell;Knowledge;Leadership;Liquid substance;member;Metabolic;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Multicenter Trials;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Non-Insulin-Dependent Diabetes Mellitus;observational cohort study;OGTT;Ohio;Outcome;Pancreas;Pancreatic Hormones;Pathway interactions;Patients;Pattern;Play;Prediabetes syndrome;prevent;Prevention strategy;Prognostic Marker;prospective;Publishing;Research Infrastructure;response;Resuscitation;Risk Factors;risk stratification;Role;Sampling;Series;Serum;Standardization;Subgroup;Supportive care;Testing;translational study;treatment strategy;Trypsin;Universities;Work

PROJECT_TITLE: Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus


ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Sleep Research;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Substance Misuse

ORG_CITY: ORANGEBURG

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: NARRATIVE Fetal alcohol spectrum disorder (FASD) is one of the primary causes of intellectual disability in western nations, with neurobehavioral hallmarks such as deficits in learning, memory and mood. Of the many long-lasting consequences of developmental ethanol exposure, sleep disruption has been identified in human and other animal studies, and our previous results indicate that sleep deficits are associated with specific interneuron reduction. Given the importance of sleep in memory consolidation, mood and attention, here we will explore how developmental ethanol affects GABA interneurons and how modifications of the cell numbers or activity improve developmental ethanol-induced sleep disruption, which may help identify treatments for FASD.

PI_NAMEs: SAITO, MARIKO  (contact);SMILEY, JOHN F

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acute;Adult;Affect;alcohol effect;alcohol exposure;Anatomy;Animals;Apoptosis;Architecture;Attention;basal forebrain;Behavioral;Biological Assay;Brain;Brain region;Brain Stem;Cell Count;cell killing;Cell Maturation;Cell Nucleus;Cell Physiology;cell type;Cells;Cognition;Cognitive;cognitive function;cognitive process;Confocal Microscopy;D Cells;Data;density;Development;Electron Microscopy;Electrophysiology (science);Equilibrium;Ethanol;Exposure to;Fetal Alcohol Spectrum Disorder;Functional disorder;Funding;gamma-Aminobutyric Acid;Glutamates;Golgi Apparatus;Hippocampus;Homeostasis;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;Intellectual functioning disability;Interneurons;Knock-out;Label;Learning;Link;Mediating;Mediator;Memory;memory consolidation;Modification;Moods;Mus;Neocortex;neocortical;nerve stem cell;Nervous System;Nervous System Physiology;neural;neural network;neurobehavioral;Neurons;non rapid eye movement;novel;optogenetics;Outcome;Parvalbumins;Pattern;Phenotype;Physiology;prevent;Prevention;progenitor;Regression Analysis;repaired;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;Sleep Wake Cycle;Somatostatin;Structure;Synapses;Techniques;Testing;Therapeutic;Transgenic Mice;Transplantation;Vasoactive Intestinal Peptide;Wakefulness;Work

PROJECT_TITLE: Long-lasting consequences of early ethanol on network activity during sleep

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Adverse effects of Tyrosine Kinase Inhibitor (TKI) drugs negatively affect survivorship in cancer patients and is a serious and growing problem. A major knowledge gap is the lack of a comprehensive delineation of the kinase networks responsible for the anti-cancer and adverse effects of these drugs. This proposal supports a physician-scientist in her final 2 years of training (K99 mentored phase) and her initial independent career (R00 phase) to develop a comprehensive molecular level understanding of the kinase inhibition networks that will inform the development of safer and more effective anti-cancer drugs.

PI_NAMEs: HNATIUK HNATIUK, ANNA PAVLOVNA (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: ABL1 gene;Acceleration;Address;Adverse drug effect;Adverse effects;Advisory Committees;Affect;analog;anti-cancer;anticancer activity;Antineoplastic Agents;Basic Science;bcr-abl Fusion Proteins;Bioinformatics;Biological Assay;Blood Vessels;Bone Marrow Suppression;Cancer Patient;Cancer Survivor;Cancer Survivorship;candidate identification;Cardiac;Cardiac Myocytes;Cardiovascular system;career;Cell Lineage;Cell model;Cell Physiology;cell type;Chemicals;Chronic Myeloid Leukemia;Clinical Sciences;Coagulation Process;Computer Analysis;Data;Development;drug development;drug efficacy;Drug resistance;Endothelial Cells;Event;Exhibits;Genetic;Goals;Health;Heart;high throughput analysis;human induced pluripotent stem cells;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;inhibitor therapy;innovation;Institution;Intervention;kinase inhibitor;Knowledge;Leadership;leukemia treatment;MAPK11 gene;Maps;Mass Spectrum Analysis;Measures;Mediating;Mentors;Mitogen-Activated Protein Kinases;Molecular;Morbidity - disease rate;mutant;Mutation;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Oncology;Pathway interactions;Patient-Focused Outcomes;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Phosphorylation;Phosphotransferases;Physicians;preservation;prevent;Process;Productivity;protective effect;prototype;Quality of life;quality of life for cancer survivors;RAF1 gene;reconstruction;Reporting;Research;Resistance;resistance mutation;response;RNA Interference;ROCK1 gene;Role;Safety;Scientist;side effect;Signal Pathway;Signal Transduction;skills;survivorship;Technology;Testing;Therapeutic;Toxic effect;Training;Troponin;tumor;Tumor Suppression;tyrosine analog;Tyrosine Kinase Inhibitor;Universities;Vascular Endothelial Cell;vasculogenesis;Xenograft Model

PROJECT_TITLE: Defining kinase interaction pathways to enhance anti-cancer efficacy and minimize associated morbidities of kinase inhibitor drugs.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ED_INST_TYPE: PRIMATE CENTERS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biomedical Imaging;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The Monkey Alcohol Tissue Research Resource is unique to the alcohol research field in promoting a translational resource for mechanistic and genetic studies of alcohol-induced pathologies in primates with known alcohol intake. The fully interactive website and analytics toolset, together with the structural foundation to examine reproducibility and reliability of phenotypes, is designed to dynamically interact with external research domains to advance holistic data integration for alcohol research.

PI_NAMEs: BENTON, MARY LAUREN;GRANT, KATHLEEN A (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Abstinence;Adult;adverse outcome;Affect;alcohol consequences;Alcohol consumption;alcohol free;alcohol research;alcohol use disorder;Alcohols;Archives;Autopsy;Award;Behavior;Bioinformatics;bioinformatics resource;Biological Models;Biopsy;Blood;bone;Brain;Categories;Central Nervous System;Chronic;chronic alcohol ingestion;cohort;Collaborations;Collection;Communities;comorbidity;Custom;Data;Data Analyses;Data Analytics;data integration;Data Set;Dedications;design;Development;Developmental Process;Dextrins;Diagnostic;Discipline;Disease;Disease Progression;drinking;Elasticity;Endocrine;Endocrinology;Equipment and supply inventories;Ethanol;Evaluation;expectation;Experimental Designs;Fatty acid glycerol esters;Female;fetal;Fetal Alcohol Exposure;Fetal Tissues;Foundations;Freezing;Functional disorder;Funding;Generations;Genetic;genetic pedigree;genetic signature;Genetic study;genomic signature;Genomics;Goals;Grant;Harvest;Health;Heavy Drinking;heterogenous data;Histologic;Human;Image;Immune;Immunology;in silico;In Vitro;in vivo imaging;Individual;Institution;Intake;interest;Investigation;Knowledge;Laboratories;large scale data;Liver;longitudinal design;Macaca;Macaca mulatta;Magnetic Resonance Imaging;male;Maltose;Medical;Modeling;Monkeys;Neuroanatomy;Neurosciences;nonhuman primate;novel;online resource;Oregon;Organ;Pathologic;Pathology;Pattern;Peer Review;Phase;Phenotype;Physiology;Positioning Attribute;Preparation;Primates;Procedures;Process;Progress Reports;Protocols documentation;Publications;recruit;Relapse;Reproducibility;Research;Research Personnel;Resources;response;Risk;Roentgen Rays;Sampling;Science;screening;Self Administration;Severities;System;Testing;Time;tissue fixing;tissue preparation;Tissue Sample;Tissues;translational applications;Ultrasonography;ultrasound;underage drinking;Universities;Variant;web based interface;web site

PROJECT_TITLE: Monkey Alcohol Tissue Research Resource (MATRR)

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The mucosal type 2 immune response is essential to orchestrate immunity to helminth infection, but if dysregulated can drive chronic allergic diseases such as asthma or food allergy. These infections and allergic diseases impact over 2 billion individuals in the world, representing a major socio-economic and public health challenge. The fundamental focus of this application is the define two novel pathways that critically regulate type 2 mucosal immunity and inflammation, which could provoke novel preventative, therapeutic or curative treatment strategies for these infectious and inflammatory diseases.

PI_NAMEs: ARTIS, DAVID  (contact);SONNENBERG, GREGORY F

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acetylcholine;Address;Agonist;Allergic Disease;Allergic inflammation;Asthma;Binding;Cell Physiology;cell type;Cells;Cellular biology;cellular targeting;Choline O-Acetyltransferase;Cholinergic Receptors;Chronic;Communicable Diseases;Critical Pathways;curative treatments;cytokine;Data;Disease;Epithelial Cells;Family;Food Hypersensitivity;Gastrointestinal tract structure;genetic approach;helminth infection;Helminths;Human;Hypersensitivity;Immune;Immune response;Immune system;Immunity;Immunology;Impairment;in vivo;Individual;Infection;Inflammation;Inflammatory;inhibitor;innovation;Interleukin-13;Interleukin-5;Interleukin-9;Intestines;Invaded;Knock-out;Knowledge;Lymphocyte;Lymphoid Cell;Mediating;Molecular;Mucosal Immune System;Mucosal Immunity;mucosal site;Mucositis;Mucous Membrane;Mus;Nervous System;Neurons;neurotransmission;Neurotransmitters;neurotrophic factor;next generation;Nippostrongylus;novel;novel therapeutic intervention;Parasites;pathogen;Pathway interactions;prevent;Production;Public Health;Receptor Protein-Tyrosine Kinases;Regulation;response;Role;Sampling;Signal Transduction;small molecule;socioeconomics;Testing;Therapeutic;therapeutic target;Tissues;tool;Translating;treatment strategy;TSLP gene

PROJECT_TITLE: Regulation of mucosal immunity by neuronal pathways


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Congenital Structural Anomalies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The objective of this proposal is to identify risk factors for anotia and microtia in Hispanic and non-Hispanic populations. This proposal will accomplish its objective by evaluating the associations of individual and neighborhood-level social/environmental factors, genetic variation, and maternal exposures with anotia and microtia, using data from population-based birth defects registries, biobanking programs, and the National Birth Defects Prevention Study. This information may inform future etiologic studies, facilitate targeted prevention efforts in high-risk populations, and reduce ethnic disparities in the prevalence, diagnosis, and treatment of anotia and microtia.

PI_NAMEs: SCHRAW, JEREMY  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Address;Adverse event;adverse outcome;Affect;American;Amerindian;Anxiety;Archives;Awareness;biobank;bioinformatics tool;biological specimen archives;Birth;Blood;California;case control;causal variant;Characteristics;Child;childhood hearing loss;Clinical Management;Confidence Intervals;Congenital Abnormality;congenital anomaly;Data;Diagnosis;Diet;Disease;Disparity;Ear;Education;Environment;Environmental Risk Factor;Epidemiology;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Etiology;External Ear;Facial nerve structure;forest;Future;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;Genotype;health disparity;Hearing;hearing impairment;Heritability;high risk population;Hispanic;Hispanic Populations;Human Genetics;Individual;Infant;insight;Investigation;Latinx population;Life Cycle Stages;Live Birth;Machine Learning;Maps;Maternal Exposure;Maternal Health;member;Mental Depression;Methods;microtia;Monitor;Mothers;multi-ethnic;multidisciplinary;Neighborhoods;Neonatal;non-genetic;Not Hispanic or Latino;novel;Operative Surgical Procedures;Participant;Patient Self-Report;Pediatric Research;peer;Pharmaceutical Preparations;Population;population based;Population Heterogeneity;Prevalence;Prevention;Primary Prevention;programs;Reconstructive Surgical Procedures;Registries;residence;Risk;Risk Estimate;Risk Factors;Role;segregation;social;sociodemographic factors;sociodemographics;Socioeconomic Factors;Socioeconomic Status;Spottings;Syndrome;Techniques;Texas;Time;Uninsured Medical Expense;Update;Validation;whole genome;Work

PROJECT_TITLE: Leveraging Ethnic Anotia-microtia Disparities for Discovery (LEADD) Study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH FOUNDATION

ORG_STATE: PA

PHR: Project Narrative Patients who have experienced a stroke or other brain injury frequently experience anomia - a condition in which they are unable to produce words when speaking. One major challenge in this area is the lack of theoretically driven and psychometrically robust metrics to support treatment efficacy research, and to provide a unified measurement framework for rehabilitation, reimbursement, and policy decisions. Our goal is to create a computerized system for measuring relevant aspects of an individual’s anomia that will link existing tests to a universal metric, thereby opening the door to new ways of treating anomia and reducing clinical workload.

PI_NAMEs: FERGADIOTIS, GERASIMOS ;HULA, WILLIAM D. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;Agreement;Algorithms;American;Anomia;Aphasia;Aphasiology;archived data;Area;Assessment tool;Bayesian Method;Brain Injuries;Calibration;Clinic;Clinical;clinical decision-making;clinical practice;Cognitive;Cognitive deficits;Computer Models;computerized;Computers;Data;Data Set;Development;Diagnosis;Diagnostic;Disease;efficacy research;Engineering;Equation;Exhibits;experience;flexibility;Frequencies;Future;Goals;improved;Individual;instrumentation;Investigation;Length;lexical;Link;Measurement;Measures;Methods;Modeling;Modification;Names;National Institute on Deafness and Other Communication Disorders;Outcome;Parameter Estimation;Participant;Patients;Persons;Philadelphia;Policies;predictive modeling;predictive test;Process;Production;Property;Psychometrics;Rehabilitation therapy;Research;response;Sampling;Severities;simulation;Specific qualifier value;Strategic Planning;Stroke;Structure;System;Techniques;Technology;Testing;Theoretical model;theories;Time;Treatment Efficacy;treatment research;Validation;Work;Workload

PROJECT_TITLE: Assessment of anomia: Improving efficiency and utility using item response theory


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Moving our eyes between targets located at different distances from us requires disjunctive saccades and holding our eyes on each target requires the integration of vergence signals to produce a maintained vergence angle. Individuals with strabismus do not coordinate their eyes sufficiently to fixate targets in this way, but little is known about the neural control of disjunctive saccades and vergence integration in normal subjects. Our proposed studies aim to understand the role of the interconnected neural circuitry in the central mesencephalic reticular formation, supraoculomotor area and cerebellum that allows individuals to make disjunctive saccades and maintain vergence angle as they view targets in three-dimensional space.

PI_NAMEs: QUINET, JULIE  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;abducens nucleus;Amblyopia;Anatomy;Animals;Area;Brain region;Cell Nucleus;cell type;Cells;Cerebellar Nuclei;Cerebellum;Code;Complex;Contralateral;Convergence Insufficiency;Data;disability;electrical microstimulation;Electrophysiology (science);Elements;Environment;Esotropia;experimental study;Eye;Eye Movements;Functional disorder;gaze;Generations;Goals;Impairment;Individual;Injections;insight;interest;Lateral;Maintenance;Medial;Modeling;monocular;Motor Activity;Motor Neurons;Movement;Muscimol;neural;neural circuit;Neural Interconnection;neural model;Neurons;neurophysiology;neuroregulation;novel;Nucleus fastigii;oculomotor;Oculomotor nucleus;Pathway interactions;pharmacologic;Play;Population;Positioning Attribute;Primates;Production;response;Reticular Formation;Role;Route;Saccades;sample fixation;Signal Transduction;Strabismus;targeted imaging;Techniques;Testing;Time;Visual

PROJECT_TITLE: Neural control of coordinated eye movements

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Genetics;Human Genome;Liver Disease;Nutrition;Obesity

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is a burgeoning obesity-associated complication that is more common in men. The molecular and genetic basis for NAFLD and its sex-biased risk is incompletely understood. In this project, we elucidate a gene switch controlling liver sex-specific programming and fat accumulation. Insights from these studies may identify a therapeutic pathway to halt or reverse fatty liver disease.

PI_NAMEs: BARISH, GRANT D (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Ablation;Acetylation;Adipocytes;American;BCL6 gene;Bile Acids;Binding;biological sex;ChIP-seq;Chromatin;Chromatin Loop;Complication;Consensus;Disease;Disease susceptibility;DNA;end stage liver disease;Energy Metabolism;ESR1 gene;Exhibits;experimental study;Fatty acid glycerol esters;fatty liver disease;Female;Fibrosis;G-Protein-Coupled Receptors;gain of function;Gene Expression;gene network;gene repression;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genomics;glucose tolerance;GPBAR1 gene;Hepatic;Hepatocyte;histone modification;Histones;in vivo;insight;Ligation;Link;Lipids;Liver;loss of function;Lysine;male;Maps;Masculine;men;Metabolic;Metabolic Diseases;Metabolism;Molecular;Morbidity - disease rate;Mus;mutant;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nuclear;Obesity;overexpression;Overnutrition;oxidation;Pathway interactions;Phase;Physiological;Play;PPAR alpha;Production;receptor;recruit;Regulation;Regulator Genes;Repression;Resolution;Risk;Role;sex;Sex Bias;sexual dimorphism;Signal Transduction;Site;Sterols;Structure of germinal center of lymph node;subcutaneous;Switch Genes;Testing;Therapeutic;transcription factor;transcriptomics;Up-Regulation;virtual;Work

PROJECT_TITLE: Nuclear Repressors in Genomic Control of Healthful Obesity

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Amyotrophic lateral sclerosis (ALS) and Frontotemporal Dementia (FTD) are part of a devastating neurodegenerative disease spectrum for which there are no biomarkers and only limited treatments, stemming from a poor understanding of its pathogenesis. Here, we propose to integrate novel biophysical tools with spatially resolved transcriptomic and proteomic analyses of mouse models and clinically well-characterized post- mortem ALS-FTD brains to determine the specific molecular underpinnings of functional impairment in this disease. By integrating our analysis across different scales (from the cellular to the organismal), our ultimate goal is to unveil how disease-associated pathology is linked to dysfunction in specific cell types in ALS-FTD, which may in turn foster precision medicine-based treatment strategies.

PI_NAMEs: HOLT, LIAM J;PHATNANI, HEMALI  (contact);YAMAMOTO, AI

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Adult;Affect;Age;age related;ALS patients;Amyotrophic Lateral Sclerosis;Animal Model;Architecture;Autopsy;Back;Biological Markers;Biology;biophysical properties;biophysical tools;Biophysics;Brain;Cell Communication;Cell model;Cell Physiology;cell type;Cells;Cellular biology;Chronic;Clinical;cohort;Communication;Complex;Crowding;design;Disease;Disease Marker;Dissociation;Edema;Environment;Etiology;Event;extracellular;Extracellular Matrix;feeding;Fostering;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Functional impairment;Genomics;Goals;Homeostasis;human disease;in vivo;Individual;Inflammation;Injury;innovation;insight;intercellular communication;Intracellular Transport;Knowledge;Lead;Link;Macromolecular Complexes;Measures;Mechanics;Minority;Molecular;molecular marker;mouse model;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;novel;Osmosis;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Phenotype;precision medicine;Property;protein aggregation;protein protein interaction;protein TDP-43;Proteins;Proteomics;proteostasis;Shapes;Signal Transduction;Site;Solubility;sporadic amyotrophic lateral sclerosis;stem;Stress;stressor;Surveys;TDP-43 aggregation;Technology;Testing;Therapeutic;Tissues;tool;transcriptomics;Transport Process;treatment strategy;Viscosity;Work

PROJECT_TITLE: The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SAN FRANCISCO

PHR: Project Narrative The survival of pathogenic bacteria such as Bacillus anthracis, Yersinia pestis, and Salmonella enterica relies on ATP-binding cassette (ABC) transporters for the acquisition of extracellular nutrients from the environment. Despite this crucial role of ABC transporters, how these transporters identify substrates and utilize ATP is not fully understood. The overall goal of this project is to dissect individual steps in the mechanisms of ABC transporters which will aid in the development of new strategies to combat infection and attenuate virulence.

PI_NAMEs: YANG, JANET G. (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Adopted;Affect;Ataxia;ATP Hydrolysis;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Attenuated;Bacillus anthracis;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;biophysical techniques;Cell membrane;Cell Physiology;Cells;Cellular Membrane;Chimera organism;combat;Conflict (Psychology);Coupled;Coupling;Crystallography;Cystic Fibrosis;Cytoplasm;Data;Development;Disease;Disparate;Ensure;Environment;environmental change;Enzymatic Biochemistry;Enzymes;Equilibrium;Escherichia coli;experimental study;extracellular;flexibility;Fluorescence Anisotropy;Goals;Homeostasis;Human;Hydrolysis;Impairment;in vivo;Individual;Infection;insight;Integral Membrane Protein;Ions;Kinetics;Link;Measures;Mediating;Membrane;Methionine;Modeling;Multi-Drug Resistance;mutant;Nature;Nucleotides;Nutrient;Organism;pathogenic bacteria;Pathway interactions;Peptides;periplasm;Periplasmic Proteins;Polysaccharides;Process;Property;proteoliposomes;Reaction;response;Role;Salmonella enterica;Sideroblastic Anemia;Site;Structural Models;Structure;System;Testing;Thermodynamics;tool;Toxin;Transition Elements;Transport Process;Uncertainty;uptake;Virulence;Work;Yersinia pestis

PROJECT_TITLE: Mechanisms of Substrate Selectivity and Transport by a Bacterial Methionine ABC Importer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Prevention;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: We propose to develop an implementation-ready intervention that allows patients to intensify their antihypertensive medications at home under guidance from their primary care physician and following a titration algorithm. To achieve this, we will conduct qualitative interviews with key stakeholders to determine barriers and facilitators to implementation of antihypertensive self-titration in routine practice, use a large real- world dataset to assess adherence to antihypertensive medications, develop the intervention and supporting materials, perform usability testing, and prepare a proposal to test this intervention in a pragmatic, randomized trial. The overarching goal of the project is to develop an innovative alternative model of hypertension care that has the potential to improve blood pressure control, patient self-efficacy, and disease understanding, and it is highly aligned with the central mission and priorities of the National Heart, Lung, and Blood Institute (NHLBI).

PI_NAMEs: HAFF, NANCY  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acceleration;Adherence;Adoption;Adult;Algorithms;Anti-Hypertensive Agents;Area;Biometry;Blood Pressure;blood pressure control;blood pressure reduction;Cardiology;Cardiometabolic Disease;Cardiovascular Diseases;Cardiovascular system;career;career development;Caring;Cessation of life;Characteristics;Charge;Clinic;Clinical;Coronary heart disease;cost;cost effectiveness;Crystallization;Data;Data Set;design;Development;Diagnosis;Disease;Disease Management;disorder prevention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Ensure;Environment;Equipoise;Evidence based treatment;Family member;follow-up;Goals;Grant;Guidelines;Health Services Research;Heart failure;Home;Hypertension;hypertension control;hypertension treatment;Immersion;implementation design;implementation facilitators;Implementation readiness;implementation science;improved;Infrastructure;innovation;Intervention;Interview;Leadership;Literature;medication compliance;medication nonadherence;Mentors;Mentorship;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel strategies;Patient Care;patient oriented;Patient Preferences;Patients;Pattern;Pharmaceutical Preparations;Population;practice factors;Prevention;Preventive;Primary Care;Primary Care Physician;primary care practice;primary care setting;programs;Protocols documentation;Provider;provider factors;Publishing;Qualitative Methods;Randomized;randomized trial;Reaction;Recommendation;Regimen;Research;Research Methodology;Review Literature;Risk Reduction;routine care;routine practice;Self Efficacy;Self Management;sociodemographics;Stroke;Structure;systematic review;team-based care;Testing;Titrations;Training;treatment choice;treatment guidelines;usability;Work;Writing

PROJECT_TITLE: Development of an implementation-ready antihypertensive self-titration intervention to improve US blood pressure control

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  PARP inhibitor resistance is a growing clinical problem, and alternative therapeutic strategies are needed. Hyperactivation of Wnt/beta-catenin signaling drives PARP inhibitor resistance and immune evasion. Thus, we hypothesize that combining a Wnt inhibitor with a checkpoint blockade (e.g., anti-PD-1) could overcome PARPi resistance and activate an anti-tumor immune response. In our unique PARP inhibitor- resistant models, we propose to examine the anti-tumor effect of a first-in-class Wnt/ beta-catenin inhibitor in a syngeneic and humanized mouse models.

PI_NAMEs: BITLER, BENJAMIN G (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: alpha catenin;Anti-Inflammatory Agents;anti-PD-1;anti-tumor immune response;antitumor effect;Attenuated;B-Lymphocytes;beta catenin;Biological Markers;Biological Models;Biological Sciences;brca gene;Cancer Biology;cancer cell;Cancer cell line;cancer infiltrating T cells;Cancer Model;cancer type;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;Cell Line;Cells;Cessation of life;chromatin immunoprecipitation;Clinic;Clinical;Clinical Management;Clinical Trials;Collaborations;Colorado;comparison control;Complement Factor D;CSF2 gene;cytokine;Data;Detection;differential expression;Disease Resistance;DNA Repair;Down-Regulation;Effectiveness;effector T cell;efficacy testing;Engraftment;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial ovarian cancer;Future;Genes;Genetic;Genetic Transcription;Goals;homologous recombination;humanized mouse;IL6 gene;Immune;immune activation;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune checkpoint blockers;Immune Evasion;Immune signaling;immunogenic;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo Model;Inflammation;Inflammatory;inhibitor;innovation;Interferons;Investigation;IRF1 gene;knock-down;Literature;Macrophage;Macrophage Activation;Malignant neoplasm of ovary;Measures;Mediating;Modeling;mouse model;mutant;Mutate;novel;novel therapeutics;Ovarian Serous Adenocarcinoma;overexpression;paracrine;Paracrine Communication;Pathway interactions;patient derived xenograft model;Patients;PD-1/PD-L1;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Prognosis;programmed cell death ligand 1;Progression-Free Survivals;Proteins;Publishing;Recurrence;refractory cancer;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resistance;response;Role;Serous;Serum;Signal Transduction;success;T cell differentiation;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy resistant;TNF gene;tumor;Tumor Immunity;Tumor Promotion;Tumor Suppressor Proteins;tumor-immune system interactions;Universities;Up-Regulation;WNT Signaling Pathway;Work;Xenograft Model

PROJECT_TITLE: Targeting Wnt signaling in therapy-resistant ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Follicular lymphoma (FL) constitutes the second most common B-cell Non-Hodgkin's lymphoma (B-NHL) with an annual incidence of ~15,000 cases and more than 100,000 patients in the US living with the disease. Despite improvements in the survival of FL patients, the disease remains incurable and patients go through cycles of treatment, remission and relapse. In this proposal we outline our approach for the study of common STAT6 mutations that drive this disease with possible future opportunities for novel therapy development.

PI_NAMEs: MALEK, SAMI NIMER (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Amino Acids;ARID1A gene;ATAC-seq;ATP6AP1 gene;Autophagocytosis;B-Cell Lymphomas;B-Cell Neoplasm;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Binding;Binding Sites;Biological;Biology;CCL17 gene;Cell Line;Cell Survival;Cells;Cellular biology;Characteristics;Chronic Lymphocytic Leukemia;Data;data integration;Dependence;Disease;Disease remission;DNA Binding;DNA Binding Domain;Ecosystem;Enhancers;experimental study;Follicular Lymphoma;Follow-Up Studies;FRAP1 gene;Frequencies;Future;gain of function;Gene Expression;Gene Modified;Gene Mutation;Genes;Genetic Transcription;genome-wide;Histones;Hodgkin Disease;Human;Immuno-Chemotherapy;Immunotherapy;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Intercistronic Region;Interleukin-4;Introns;large cell Diffuse non-Hodgkin's lymphoma;Link;lymph nodes;Lymphoma;Lymphoma cell;Mantle Cell Lymphoma;Maps;Mediastinal;Molecular;mutant;Mutate;Mutation;new therapeutic target;Non-Hodgkin's Lymphoma;Non-Malignant;novel;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;preference;programs;promoter;Property;Proteins;Publishing;Recombinants;Recurrence;Relapse;Repression;Role;side effect;standard of care;STAT protein;STAT6 gene;STAT6 Transcription Factor;Structure of germinal center of lymph node;Survival Rate;T-Lymphocyte Subsets;targeted treatment;therapeutic target;therapy development;transcription factor;transcriptome;Work

PROJECT_TITLE: The Biology of Mutant STAT6 in Follicular Lymphoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Fibrosis, or scarring, causes dysfunction and ultimate failure of numerous tissues with aging and disease, and is characterized in part by increased tissue stiffness. Despite estimates that fibrosis contributes to 45% of U.S. deaths, no adequate model system exists to study fibrotic stiffening on individual cells in real time. This project aims to develop novel dynamic material platforms that enable user-directed manipulation of stiffness and to apply these systems to identify the molecular mechanisms by which fibrotic stiffening leads to cellular dysfunction.

PI_NAMEs: BLAU, HELEN M (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Aging;Architecture;Attention;Biochemical;Biocompatible Materials;Biogenesis;Biological Models;biomaterial compatibility;Biophysics;bisulfite sequencing;blood pump;Cardiac Myocytes;Cardiomyopathies;Cell Culture Techniques;Cell Death;Cells;Cessation of life;Chemistry;Chromatin;Chronic;Cicatrix;Contracts;Cues;cycloaddition;Cytoskeleton;Defect;Deposition;design;Disease;DNA Damage;DNA Methylation;Duchenne muscular dystrophy;Dystrophin;Engineering;Epigenetic Process;Exhibits;Exposure to;Extracellular Matrix;fabrication;Failure;Family;Fibrosis;Fluorescence Microscopy;Formulation;Free Radicals;Functional disorder;Gel;Generations;Genetic Diseases;Goals;Guanosine Triphosphate Phosphohydrolases;Heart;Heart failure;Heritability;Human;human induced pluripotent stem cells;Hydrogels;Impairment;imprint;In Situ;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Inflammation;inherited cardiomyopathy;insight;Intervention;Knowledge;Light;link protein;Liver;Lung;Measures;Mechanics;mechanotransduction;Mediating;Memory;Microscopy;Mitochondria;Modeling;Modification;Molecular;Mutation;novel;novel strategies;Organ failure;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Production;Property;Proteins;Reaction;Reactive Oxygen Species;Research;Research Proposals;response;rho;rho GTP-Binding Proteins;Role;Sarcomeres;Signal Transduction;Skeletal Muscle;Stimulus;Stress;Structural Protein;System;temporal measurement;Therapeutic Intervention;Time;Tissue Model;tissue regeneration;tissue repair;Tissues;Traction Force Microscopy;Work;wound healing

PROJECT_TITLE: Dynamic Biomaterial Design to Probe the Cellular Response to Fibrotic Stiffening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project narrative Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy. The proposed research seeks to test a provider-facing decision support tool and a patient-facing smartphone app to reduce the amounts of opioids prescribed and taken following discharge, while ensuring effective treatment of pain after surgery. Increasing access to safe, affordable, and high-quality pain therapy for surgical patients will drive the positive impact of this proposal.

PI_NAMEs: BARTELS, KARSTEN  (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Efficiency And Quality In Post-Surgical Pain Therapy After Discharge - EQUIPPED

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative PACS1 R203W pathogenic substitution is solely responsible for over 200 patients presenting with the ASD- associated disease, PACS1 Syndrome, yet the mechanisms that lead to the neurodevelopmental defects remain largely unknown. Moreover, genome-wide association studies (GWAS) identified the human PACS1 locus as a susceptibility gene in severe early-onset obesity, developmental delay, and bipolar disorder, suggesting a broader role in neural development and function. In this proposal, we will use modern molecular biology and stem cell techniques combined with neuroscience tools to better understand the pathogenic mechanisms by which PACS1 deficits affect the developing nervous system, possibly revealing convergent therapy targets.

PI_NAMEs: GUEMEZ GAMBOA, ALICIA DIONE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Address;Affect;Arginine;autism spectrum disorder;Binding;Bipolar Disorder;Brain;cancer cell;Cell Death;Cell Line;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;Cerebral cortex;Cerebrum;Chromatin;Complex;Cytoplasm;Data;Data Set;Defect;design;Development;Developmental Delay Disorders;differential expression;Disease;Dorsal;effective therapy;Endosomes;Equilibrium;Etiology;experimental study;Family;Foundations;FOXG1B gene;Funding;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;genome wide association study;Glutamates;Goals;Histone Deacetylase;Human;Impaired cognition;Individual;induced pluripotent stem cell;Knowledge;Label;Lentivirus;Location;Mediating;Modernization;Molecular;Molecular Biology;myocyte-specific enhancer-binding-factor 2C;nerve stem cell;Nervous System;nervous system development;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurologic;neuromechanism;Neuronal Differentiation;Neurons;Neurophysiology - biologic function;Neurosciences;Nuclear;Nuclear Localization Signal;Organoids;PACS1 Syndrome;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Process;programs;Proliferating;Prosencephalon;protein transport;Proteins;Recurrence;Research;Role;S phase;severe early onset obesity;single-cell RNA sequencing;Sorting;Specific qualifier value;Stains;stem cells;Structure;Susceptibility Gene;SWI1;synaptogenesis;targeted treatment;Techniques;Testing;Tissue-Specific Gene Expression;tool;trans-Golgi Network;transcriptome;Tryptophan;Variant;Work

PROJECT_TITLE: Identifying pathogenic mechanisms underlying PACS1 Syndrome: implications for neural development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Ventricular arrhythmias and sudden cardiac arrest, as well as cardiac dysfunction, are major causes of mortality and morbidity, carrying great economical and societal impact. Our research focuses on an inherited disease called “arrhythmogenic right ventricular cardiomyopathy” caused by mutations in the PKP2 gene, coding for a desmosome protein, plakophilin-2. We will use modern physiology, genomics, proteomics, and microscopy methods to investigate the mechanisms underlying the onset of the disease at the molecular level.

PI_NAMEs: SMALL, ERIC M (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acceleration;Adhesions;Architecture;Arrhythmia;arrhythmogenic cardiomyopathy;Arrhythmogenic Right Ventricular Dysplasia;Attention;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Communication;Cell Death;Cell membrane;Cell Nucleus;Cell surface;Cell-Matrix Junction;Cells;Chromatin;Code;Complex;Coupling;Cytoskeleton;Data;Desmin;desmoplakin;Desmosomes;Disease;disease phenotype;Disease Progression;DNA Damage;druggable target;Ecosystem;env Gene Products;experimental study;Filament;Foundations;Functional disorder;Gene Expression;gene repression;Genes;Genetic Diseases;Genetic Epistasis;Genetic Transcription;Genome;Genomics;Heart Arrest;Hereditary Disease;Homeostasis;Human;Image;Induced Mutation;Intercalated disc;Intermediate Filaments;Knowledge;Lamin Type A;Lamins;Life;Link;mechanical load;Mechanics;Mediating;Methods;Microscopy;Microtubules;Modernization;Molecular;molecular imaging;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Mutant Strains Mice;Mutation;Myocardial;Myocardial dysfunction;Myocardium;novel therapeutic intervention;Nuclear;Nuclear Envelope;Nuclear Lamina;Nuclear Structure;Onset of illness;Organelles;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Physiology;plakophilin 2;prevent;Proteins;Proteome;Proteomics;Publishing;Reporting;Research;response;Role;Sampling;scaffold;Signal Transduction;single molecule;Structure;Surface;Testing;Tissues;TP53 gene;transcriptional reprogramming;transcriptomics;Translating;transmission process;Variant;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Intercalated disc-nuclear lamina coupling as a molecular substrate for arrhythmogenic cardiomyopathy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This project develops computational tools for automatically and accurately determining atomic structure from low-resolution cryo-electron microscopy data. The proposed work will lead to dramatic improvements in our ability to model dynamic structures of protein complexes. Obtaining accurate structures from this data will reveal insights into the workings of biomedically important protein complexes, and what goes wrong in human disease.

PI_NAMEs: DIMAIO, FRANK P (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Adopted;atomic interactions;autoencoder;Biological;Biology;Chemical Models;Collaborations;Complex;computational suite;Computer software;computerized data processing;computerized tools;Computing Methodologies;Cryoelectron Microscopy;Custom;Data;data analysis pipeline;Data Collection;data quality;Data Set;deep learning;density;Drug Design;Drug Targeting;Electrons;flexibility;Goals;Grant;Heterogeneity;heterogenous data;human disease;Image;improved;insight;interest;Ions;Learning;Ligands;Location;Machine Learning;Maps;Methodology;Methods;Microscopy;model building;Modeling;Molecular Conformation;Molecular Machines;Mutation;neural network;particle;Positioning Attribute;Productivity;protein complex;protein structure;protein structure prediction;Proteins;Publications;reconstruction;Research;Resolution;Set protein;Structural Models;Structure;System;three dimensional structure;tool;Training;Variant;Work;X ray diffraction analysis

PROJECT_TITLE: Protein structure determination from low-resolution experimental data

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Affinity Gradient-Based Transport of HIV Capsid Cores Through the Nuclear Pore Complex: Project Narrative HIV-1 infects cells by passing its capsid core with the viral genome through the Nuclear Pore Complex (NPC), a process that involves intricate and poorly understood interactions between the viral and NPC components. We propose a hypothesis that HIV-1 capsid core is a complex transporter that is translocated via an opportunistic affinity gradient that consists of various “signatures” on specific NPC components naturally distributed along the nucleo-cytoplasmic axis of the NPC. Knowledge of the molecular interactions during HIV-1 nuclear import will shed light on the strategy HIV-1 deploys to deliver its genome to the nucleus; our fundamental understanding of NPC function; provide a framework for studies of the nuclear import of other viruses; and potential approaches to novel antiviral therapies.

PI_NAMEs: MELCAK, IVO  (contact);SARAFIANOS, STEFAN G

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Affinity;Anti-viral Therapy;Arginine;Back;Binding;Biochemical;biophysical properties;biophysical techniques;Capsid;Capsid Proteins;Cell Nucleus;Cells;Chemicals;Complex;Cone;Crystallography;Cytoplasm;Cytoplasmic Filaments;Data;Diameter;Disease;DNA;Docking;Electron Microscopy;Encapsulated;Etiology;Eukaryotic Cell;Event;Exhibits;experimental study;Fullerenes;Genome;Glycine;HIV;HIV-1;Hydrophobicity;imaging approach;insight;Interphase Cell;Knowledge;Label;Lentivirus;Leucine;Life;Light;Manuals;Measures;Molecular;multidisciplinary;mutant;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Penetration;Peptides;Phenylalanine;Process;Proteins;Publishing;receptor;Reporting;Resolution;Reverse Transcription;Roentgen Rays;Role;segregation;Shapes;Site;Spectrum Analysis;Structure;Surface Plasmon Resonance;System;Techniques;Viral;Viral Core Proteins;viral DNA;Viral Genome;Virus;Work

PROJECT_TITLE: Affinity Gradient-Based Transport of HIV Capsid Cores through the Nuclear Pore Complex

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: This proposal aims to develop an interconnected set of modeling tools to support elimination of communicable diseases. A variety of processes used to achieve disease elimination will be considered including use of mass drug administration to eliminate neglected tropical diseases such as trachoma, vaccination for preventable diseases such as SARS-CoV-2, and antibiotic stewardship efforts to curtail drug resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA). Besides improving our scientific understanding of disease transmission, hypotheses validated through mathematical modeling provide public health practitioners with a more structured, quantitative assessment of how elimination of specific pathogens can be achieved.

PI_NAMEs: BLUMBERG, SETH  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Address;Antibiotics;Area;burden of illness;Communicable Diseases;Communities;Community Health;Compensation;Computer Models;Contact Tracing;Data;data integration;Databases;design;Disease;disease model;disease transmission;Drug resistance;Endemic Diseases;Epidemiology;Event;Goals;Heterogeneity;improved;in silico;Individual;Infection;Intervention;mathematical model;Measurement;methicillin resistant Staphylococcus aureus;Modeling;Monitor;neglected tropical diseases;pathogen;Pattern;Performance;Persons;Pharmaceutical Preparations;Population;Predisposition;Process;programs;Public Health;Scanning;simulation;Site;statistics;Structure;Techniques;Testing;tool;Trachoma;transmission process;Treatment Efficacy;Vaccination;vaccine acceptance

PROJECT_TITLE: Modeling the dynamics of disease elimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Mental Health;Neurosciences;Pain Research;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Traumatic stress disorders increase the risk for developing alcohol use disorder (AUD) and are associated with higher incidence of chronic pain in humans. The proposed work will test 1) traumatic stress effects on the activity of amygdala cells that project to reward/aversion and pain centers and 2) the role of specific amygdala cells in mediating stress effects on alcohol reward/aversion and sensory nociception & pain avoidance. We will use an established animal model of traumatic stress in combination with brain slice electrophysiology, neuroanatomical tract-tracing, retrograde neural labeling, molecular biology, pharmacology and circuit-based approaches to test neurobiological mediators of stress effects on behavior.

PI_NAMEs: GILPIN, NICHOLAS WARREN (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Affect;Alcohol consumption;alcohol effect;alcohol reward;alcohol use disorder;Alcohols;American;Amygdaloid structure;anatomical tracing;Anatomy;Animal Model;Behavior;Bobcat;Brain;Cells;Cessation of life;Chronic Disease;chronic pain;Corticotropin-Releasing Hormone;cost;Data;Diagnosis;drug of abuse;DSM-V;Electrophysiology (science);Exhibits;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Exposure to;Female;Funding;Goals;Human;Hyperalgesia;Hypothalamic structure;Incidence;indexing;Label;Lateral;male;Mediating;Mediator;midbrain central gray substance;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;mortality;neural;Neuroanatomy;Neurobiology;Neurons;Neuropeptides;Nociception;Odors;Pain;Pain Clinics;pain outcome;Patients;Peptides;pharmacologic;Pharmacology;Population;Post-Traumatic Stress Disorders;Publishing;Rattus;receptor;Receptor Cell;Rewards;Risk;Role;Self Administration;Sensory;Site;Slice;Stress;Stress Tests;Symptoms;Techniques;Testing;traumatic stress;Traumatic Stress Disorders;treatment strategy;Urine;Work

PROJECT_TITLE: Role of Neuropeptides in Stress-Induced Escalation of Alcohol Drinking


NIH_SPENDING_CATS: Clinical Research;Hematology;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Project Narrative Over the past 30 years techniques of obtaining allografts for stem cell transplantation has shifted to increasing use of blood stem cell grafts collected by apheresis, in spite of higher rates of chronic graft-versus-host disease seen among recipients of G-CSF-mobilized grafts compared with marrow grafts. Our research has shown that rare antigen presenting cells in the graft, called dendritic cells, have a significant influence on the incidence and severity of graft-versus-host disease. Our work will define the type of donor dendritic cell that most effectively limits graft-versus-host disease without compromising the graft-versus-leukemia activity of the transplant, and will optimize novel ways of obtaining donor grafts that are enriched for this cell population.

PI_NAMEs: WALLER, EDMUND K (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: adaptive immunity;Address;Adoptive Cell Transfers;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;Allografting;allotransplant;AMD3100;antagonist;Antigen-Presenting Cells;Biological Models;Blood;Blood Cells;Blood Component Removal;Bone Marrow;bone marrow allograft;Bone marrow failure;Bone Marrow Transplantation;cancer cell;Cell Compartmentation;Cell Physiology;Cells;chemokine;chemokine receptor;chronic graft versus host disease;Clinical;clinical application;clinical practice;Clinical Trials;Communicable Diseases;cost effective;CSF3 gene;CXCR4 gene;cytokine;Cytometry;Data;Dendritic Cells;Drug Receptors;Engineering;Engraftment;Enzymes;FLT3 gene;FLT3 ligand;Future;Gene Expression Profile;Gene Modified;Generations;Goals;Graft Rejection;graft vs host disease;graft vs leukemia effect;Harvest;hematopoietic engraftment;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Homing;Human;Immune;Immunity;Immunologics;immunoregulation;improved;in vivo;Incidence;Injections;Interleukins;Intervention;Knockout Mice;Luciferases;Lymphoid;Marrow;Mediating;Medicine;Methods;migration;Molecular;mortality;mortality risk;Mus;Neuropeptides;novel;novel strategies;Operating Rooms;Opportunistic Infections;Organ;Organ Transplantation;Outcome;Pathway interactions;Patients;Peptides;Phenotype;Physicians;Population;post-transplant;pre-clinical;preclinical study;Procedures;Publishing;Quality of life;Recurrent disease;Regulatory T-Lymphocyte;Relapse;Research;Sampling;secondary lymphoid organ;Severities;single-cell RNA sequencing;Solid;Source;Stem Cell Mobilization;Stem cell transplant;stem cells;T-Cell Activation;T-Lymphocyte;Technical Expertise;Techniques;Testing;Time;Tissues;Toxic effect;Transgenic Mice;Translating;transplant model;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE We are developing new nanoscale mechanical techniques and theoretical models to study cells and biomolecules, and we use these approaches to visualize dynamics of biomolecules in physiologically relevant conditions and study the physiological role of various forces and mechanical properties in cells. The findings can help reveal molecular and cellular mechanisms governing biological function and various diseases.

PI_NAMEs: SAHIN, OZGUR  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Atomic Force Microscopy;Biologic Characteristic;Biological Process;biological systems;Biology;biophysical model;Cell membrane;Cell model;Cells;cellular imaging;Chemicals;Coupling;Crystallization;Data;Development;Disease;Freezing;Goals;Image;imaging modality;interest;Ion Channel Gating;Laboratories;Mathematics;Measures;mechanical behavior;mechanical properties;Mechanics;Membrane Proteins;Methods;Modeling;Molecular;Morphology;nanomechanics;nanoscale;Organelles;Pattern;Physiological;prevent;programs;protein complex;Research;Research Personnel;Resolution;RNA;Role;Sampling;Shapes;structural biology;Techniques;Technology;Theoretical model;Vision;Visualization;Work

PROJECT_TITLE: Nanomechanical studies of cells and biomolecules

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Diabetes;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative  Emerging evidence suggests that autophagy abnormality is implicated in metabolic dysfunction, but the mechanism by which autophagy regulates insulin sensitivity is largely unknown. Recently we discovered a mechanistic link between autophagy and the secretion of adiponectin, an adipose tissue-derived hormone whose reduction in circulation is strongly associated with type 2 diabetes and metabolic syndrome. In this proposal, we will demonstrate the novel non-degradative, non-cell autonomous, mechanism by which the ULK1-Vps34-Becn1 autophagy machinery in adipose tissue improves systemic insulin sensitivity.

PI_NAMEs: HE, CONGCONG  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adipocytes;adipokines;adiponectin;Adipose tissue;Attention;Autophagocytosis;Autophagosome;Binding;Biochemical;Biochemistry;Cellular biology;Circulation;Complex;Data;Endocrine Glands;Endoplasmic Reticulum;feeding;Genes;Genetic;glucose tolerance;Goals;High Fat Diet;Homeostasis;Hormonal;Hormones;Human;Hyperactivity;Image;improved;Insulin;Insulin Resistance;insulin sensitivity;Knock-in Mouse;Knockout Mice;Link;LoxP-flanked allele;Lysosomes;Maintenance;Mediating;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathway interactions;pharmacologic;Phenocopy;Phenotype;Phosphotransferases;Play;prevent;Process;Proteins;Proteomics;Receptor Signaling;Regulation;Research;response;Role;Serum;Signal Transduction;System;Testing;Tissues;tool;Vesicle

PROJECT_TITLE: Autophagy-facilitated secretion in metabolic maintenance


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Rib fractures account for over 40% of all bone fractures sustained in the United States, however there remain few options for non-invasive rib fracture stabilization. This proposal will determine the utility and the efficacy of using resorbable, phosphorylated PEU (pPEU) copolymers as an innovative, non-invasive treatment for rib fracture stabilization and fracture healing. The studies of this proposal are relevant to public health in that they will lead to new therapies for a common traumatic injury for which efficacious, non-invasive treatment strategies are currently lacking.

PI_NAMEs: FERNANDEZ-MOURE, JOSEPH S. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Actins;acute care;Adhesions;Adhesives;Amino Acids;Award;base;Biocompatible Materials;biodegradable polymer;Biologic Characteristic;Biomechanics;Biomedical Engineering;bone;Bone callus;bone fracture repair;bone healing;Bone Marrow;Bone Marrow Stem Cell;Breathing;Calcium;career;career development;Cartilage;Cells;Chemicals;Chest wall structure;Chondrocytes;Clinical;clinical practice;Collagen;Contracts;copolymer;cortical bone;Critical Care;Cues;Cytoskeletal Modeling;Data;Dedications;density;Deposition;Development;Elasticity;elastomeric;Elastomers;Engineering;Esters;Ethanol;Exhibits;experience;experimental study;External Fixation Devices;Failure;Flail Chest;Focal Adhesions;Formulation;Foundations;Fracture;Future;Generations;Glycols;Goals;healing;high risk;Immobilization;improved;In Vitro;in vivo;Incidence;Injectable;Injections;Injury;innovation;inorganic phosphate;insight;interfacial;Investigation;Laboratory Research;Life;long bone;materials science;mechanical properties;mechanical signal;Mechanics;Mentors;Metabolic;minimally invasive;Modeling;Modification;Modulus;monomer;Musculoskeletal;novel;novel therapeutics;Operative Surgical Procedures;Orthopedics;Osteoblasts;Pain;Patients;Performance;Phosphorylation;Phosphoserine;Play;Pneumonia;polymerization;Polymers;Positioning Attribute;professor;Program Development;Property;Public Health;pulmonary function;Rattus;reparative process;Research;Research Personnel;rib bone structure;Rib Fractures;safety testing;Scientist;skills;Stem Cell Research;stoichiometry;Stromal Cells;Surface;Surgeon;surgery material;Tensile Strength;Testing;Tissue Engineering;Trauma;trauma care;Trauma patient;Traumatic injury;treatment strategy;United States;United States National Institutes of Health;Universities;Urea;Vertebral column;Work;wound healing

PROJECT_TITLE: Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE: Investigating the balance between cell death and inflammation, we have identified a novel mechanism of LPS-induced cell death mediated by Caspase 8 pyroptotic and the regulatory role of ZBP1 in it. We now show that the inflammatory response to LPS also requires ZBP1.This completely novel observation provides a rational for the research plan of the proposal, which will uncover new regulators of the host response to pathogens as well as novel therapeutic targets for translational intervention.

PI_NAMEs: POLTORAK, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;Address;Affect;Bacterial Infections;CASP8 gene;CD14 gene;Cell Death;Cell Death Induction;Cessation of life;Complex;cytokine;Cytosol;Data;Endosomes;Equilibrium;Experimental Models;Gene Silencing;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Hypotension;Immune response;Immunoprecipitation;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;insight;Intervention;Investigation;Kinetics;Knock-out;Ligation;Lipopolysaccharides;Macrophage;MAP Kinase Gene;Mediating;Mediator;member;Modeling;monocyte;Multiple Organ Failure;Mus;neutrophil;new therapeutic target;Nitric Oxide;novel;Nucleic Acids;Outcome;pathogen;Pathway interactions;pharmacologic;Phosphotransferases;Physiological;Play;Poison;Positioning Attribute;Predisposition;Production;Protein Kinase Interaction;Publications;Publishing;Receptor-Interacting Protein;recruit;Regulation;Reporting;Research;Resistance;response;Role;Scaffolding Protein;Secure;sensor;Sepsis;Septic Shock;Shock;Signal Transduction;Stress;Surface;synergism;Tissues;TLR3 gene;TLR4 gene;TNFRSF1A gene;trafficking;Viral;Virus Diseases;Yersinia;Yersinia infections

PROJECT_TITLE: Regulation of LPS-responses by ZBP1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hematology;Neurosciences;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Stroke

ORG_CITY: KADUNA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: BARAU DIKKO TEACHING HOSPITAL/ KADUNA STATE UNIVERSITY

PHR: Project Narrative Stroke is a devastating complication of sickle cell anemia (SCA) still occurring in approximately 11% of children affected with the disease in resource-limited countries, compared to 1% in high-income countries. In Nigeria, the country with more than 50% of the global burden of SCA, screening for at risk children using transcranial Doppler ultrasound (TCD) measurements is limited to tertiary hospitals. This mentored award is focused on initiating a stroke prevention program in a resource-limited community hospital by task shifting of TCD screening to nurses, a strategy that is expected to increase access for affected children with prompt institution of a primary prevention strategy for those with increased stroke risk.

PI_NAMEs: BELLO-MANGA, HALIMA  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Accounting;Address;adherence rate;Administrator;Adopted;Affect;American Society of Hematology;Award;Birth;Blood;Blood Transfusion;burden of illness;Central Nervous System;Cephalic;Certification;Charge;Child;Clinical;Clinical Trials;cohort;Communities;Community Hospitals;compare effectiveness;Complication;Consolidated Framework for Implementation Research;Country;Coupled;Data;Detection;Disease;Dose;Drops;Education;Effectiveness;Eligibility Determination;Evidence based practice;Family;feasibility trial;Focus Groups;Funding;General Practitioners;Goals;Guidelines;Health;Health Personnel;Healthcare;Hospitals;Human Resources;hydroxyurea;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;Incidence;Income;informant;Institution;Intervention;Interview;Lobbying;low and middle-income countries;Measurement;Mentors;Methods;Morbidity - disease rate;mortality;National Institute of Neurological Disorders and Stroke;Needs Assessment;Nigeria;Nurses;Outcome;Participant;Patients;pediatrician;Physicians;Prevention;Prevention program;Prevention strategy;Prevention trial;Primary Prevention;Process;programs;Qualitative Methods;radiologist;Random Allocation;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Personnel;Resource-limited setting;Resources;retention rate;Risk;Safety;Scientist;screening;Sickle Cell Anemia;Site;standard care;standard of care;State Government;Stroke;stroke incidence;Stroke prevention;stroke risk;Teaching Hospitals;Testing;Training;Transcranial Doppler Ultrasonography;United States;World Health Organization

PROJECT_TITLE: Primary Prevention of Stroke in Children with Sickle Cell Anaemia in Nigeria: Community vs Teaching Hospital


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: The purpose of this training program is to increase the numbers of under-represented students (specifically American Indian and Hispanic) from community colleges who pursue baccalaureate and graduate degrees in the biomedical and behavioral sciences. The training program promotes inter-institutional partnerships among New Mexico State University in Las Cruces, NM, and two regional community colleges: Dona Ana Community College and San Juan College in Farmington. The overall programmatic goal is to apply well- integrated developmental activities based on summer and academic year research training to increase student preparation and skills to successfully pursue baccalaureate and graduate degrees in biomedical and behavioral sciences.

PI_NAMEs: EVANS, VERONICA ;LYONS, BARBARA A (contact);SUBEDI, DEEPAK

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Admission activity;American Indians;Bachelor's Degree;bridge program;bridge to the baccalaureate;career;CCL7 gene;college;community college;Computers;Data;Degree program;Development;Educational workshop;Enrollment;Ethics;experience;Faculty;faculty mentor;Funding;Goals;Health;Hispanic;Institution;Instruction;Laboratories;New Mexico;Participant;posters;programs;Readiness;recruit;Reproducibility;Research;Research Training;Safety;Science;Series;skills;Structure;Students;summer research;Training;Training Programs;transfer student;undergraduate student;Universities;Visit;Writing

PROJECT_TITLE: Bridge to the Baccalaureate Research Training Program at New Mexico State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Sepsis

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Sepsis remains a major cause of morbidity and mortality, however development of effective therapies for sepsis treatment represents a major challenge. This study will focus on the investigation of novel molecular mechanisms promoting reduction of inflammatory signaling caused by Gram-positive infection. The results of this project will expand our knowledge about molecular regulation of inflammatory response and may lead to discovery of a new group of pharmacological molecules for the treatment of sepsis and other diseases associated with increased vascular leakage and inflammation.

PI_NAMEs: BIRUKOVA, ANNA  (contact);HONG, CHARLES C

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acids;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adhesions;analog;Animal Model;Antibiotic Resistance;attenuation;Bacterial Model;Blood Vessels;Cardiology;Catheters;Cause of Death;Caveolins;Cell model;Cell Physiology;Cells;Cessation of life;Chemical Injury;chemokine;Coagulation Process;Collaborations;Communities;COVID-19 pandemic;cytokine;cytokine release syndrome;Data;Development;Discipline;Disease;drug discovery;effective therapy;Endothelial Cells;Endothelium;Extravasation;Fibrosis;fighting;Frequencies;Functional disorder;G-Protein-Coupled Receptors;GPR68 gene;Human;implant material;In Vitro;in vivo;in vivo Model;Infection;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Intervention;Investigation;Knowledge;Lung;Lung infections;lung injury;mechanical stimulus;Mechanical ventilation;Mechanics;Mediating;Mediator;methicillin resistant Staphylococcus aureus;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;neutrophil;novel;novel therapeutics;Operative Surgical Procedures;Organ;pathogenic bacteria;Pathologic;Patients;Periodicity;pharmacologic;Phenotype;Primary Infection;Production;Protons;Pulmonary Inflammation;receptor;Regulation;Reporting;Resolution;respiratory;Respiratory Failure;response;Role;Scientist;sensor;Sepsis;septic;Severities;Signal Transduction;small molecule;small molecule inhibitor;Staphylococcus aureus;Stimulus;Stretching;Syndrome;Testing;Therapeutic;Therapeutic Agents;Tidal Volume;Tissues;TLR2 gene;Transfusion;United States;Vascular Endothelium;ventilation;Viral;virtual;Virus Diseases

PROJECT_TITLE: GPR68 as a novel modulator of septic lung injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Although epigenetic therapeutics are promising treatment options for cocaine use disorder, many epigenetic inhibitors are non-selective and have adverse side effects, significant issues that restrict mechanistic insight and translational applications. The proposed studies will address these limitations by using novel highly selective, clinically relevant approaches to identify and characterize epigenetic-based treatments for cocaine use disorder.

PI_NAMEs: SARTOR, GREGORY CHARLES (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;Address;Affinity;Area;Attenuated;Behavior;Behavioral;behavioral response;Binding;Binding Sites;Brain Diseases;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cell type;Clinical;clinically relevant;Co-Immunoprecipitations;Cocaine;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Data;disease model;DNA Binding;drug of abuse;drug seeking behavior;Economics;Epigenetic Process;experimental study;Extinction;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;Histone Acetylation;Histones;Individual;inhibitor;Injections;insight;Laboratories;Link;Mass Spectrum Analysis;Mediating;member;Modeling;multiple omics;neurobehavioral;new therapeutic target;novel;novel strategies;Nucleus Accumbens;Peptoids;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;prevent;Procedures;Protein Family;Proteins;Proteomics;Reader;Regulation;Research;response;Role;Self Administration;side effect;single-cell RNA sequencing;small molecule;Substance Use Disorder;substance use treatment;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;tool;transcriptomics;translational applications;Viral

PROJECT_TITLE: Domain- and protein-selective BET mechanisms in cocaine-seeking behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Psychosis

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: Psychotic symptoms (delusions and hallucinations) during Alzheimer disease cause substantial added burden for patients and families. Current medication treatments for psychosis in Alzheimer disease have limited benefits and cause substantial side effects. This project looks to accelerate the development of more effective medication treatments by generating detailed characterizations of altered protein levels in cortical synapses of individuals who experience psychosis during Alzheimer disease and using these characterizations to identify and test available medications for their ability to reverse the protein changes in mouse models of Alzheimer disease.

PI_NAMEs: KOFLER, JULIA K;SWEET, ROBERT A (contact);WANG, LIRONG

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;Actins;Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Antipsychotic Agents;Aspartylglucosaminuria;Behavior;Behavioral;Bioinformatics;Biological Assay;Biology;Caregiver Burden;Communities;Cytoskeleton;Data;data sharing;Delusions;Dendritic Spines;density;Development;disability;Disease Progression;drug candidate;drug development;drug testing;effective therapy;Elderly;Elements;Enzymes;Epigallocatechin Gallate;Excess Mortality;excitatory neuron;experience;experimental study;Face;Family;Funding;Future;Genetic;genetic association;genome-wide;Glutamates;Glycosaminoglycans;Goals;Hallucinations;Heritability;Heterozygote;Human;Impaired cognition;Impairment;Individual;innovation;Investigational Therapies;Knowledge;Link;Lysosomal Storage Diseases;Maintenance;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA Expression;multiple omics;Mus;Nerve Degeneration;Neurobiology;neuron loss;Neurons;neuropathology;novel;Outcome;Pathology;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Pharmacotherapy;Phenotype;Phosphopeptides;phosphoproteomics;Phosphotransferases;postsynaptic;postsynaptic density protein;Prefrontal Cortex;prevent;primary outcome;Protein Kinase;Proteins;Proteome;Proteomics;Psychoses;psychotic symptoms;Research;Resource Sharing;Risk;secondary outcome;Series;side effect;Signal Transduction;single nucleus RNA-sequencing;Sulfatases;Synapses;System;tau aggregation;Testing;therapy development;Toxic effect;Validation

PROJECT_TITLE: Accelerating Treatment Development for Psychosis in AD: MODEL-AD+P

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: Rotterdam

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: ERASMUS MEDICAL CENTER

PHR: PROJECT NARRATIVE Highly pathogenic bird flu viruses are a major burden for the poultry industry, animal welfare, ecology and a threat to human health. We will study the mechanisms underlying their emergence from low pathogenic forms. This research will fill major gaps in our knowledge and ultimately help to control bird flu outbreaks.

PI_NAMEs: RICHARD, MATHILDE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Address;Adenine;airway epithelium;Animal Experimentation;Animal Welfare;Animals;Anser species;Automobile Driving;Avian Influenza;Avian Influenza A Virus;Basic Amino Acids;Biological Assay;Birds;Cessation of life;Chicken Cells;Chickens;Coculture Techniques;Code;Death Rate;design;Disease;Disease Outbreaks;DNA Resequencing;DNA-Directed RNA Polymerase;Domestic Fowls;Ducks;Ecology;Economics;emerging virus;Endothelial Cells;Epithelial Cells;experimental study;Geese;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Goals;H5 hemagglutinin;H5 influenza virus;H7 hemagglutinin;Health;Hemagglutinin;Human;improved;In Vitro;in vitro Assay;in vitro Model;Industry;Infection;Influenza;influenza infection;influenza outbreak;influenzavirus;Integration Host Factors;Intervention;intestinal epithelium;Knowledge;Laridae;Measures;Modeling;Molecular;Mutation;Natural Selections;new pandemic;North America;novel;Nucleotides;pandemic potential;Pathogenicity;Peptide Hydrolases;Polymerase;Prevention;Process;programs;Research;Risk Reduction;RNA;RNA replication;RNA Sequences;Route;single molecule;Site;Species Specificity;Specificity;spillover event;stem;Structure;Stuttering;Systemic disease;Systemic infection;Testing;transmission process;Turkey bird;Uracil;Viral;Viral Genome;Viral Hemagglutinins;viral RNA;Virus;Virus Replication;Zoonoses

PROJECT_TITLE: Unravelling highly pathogenic influenza virus emergence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Heart failure is a major health problem in the United States. By definition, heart failure involves the inability of the heart to generate sufficiently forceful contractions - defined as an insufficient inotropic response. This proposal tests foundational molecular interactions that regulate force of heart contractions.

PI_NAMEs: SATIN, JONATHAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adrenergic Receptor;Agonist;Angiotensins;Animal Model;antagonist;Attenuated;Binding;Biophysics;Bypass;C-terminal;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium Channel;Cardiac health;Cessation of life;Clinical Trials;Cyclic AMP-Dependent Protein Kinases;Data;disease model;Diuretics;Down-Regulation;early phase clinical trial;Failure;Family;Family suidae;follow-up;gain of function;Gene Modified;genetic approach;Goals;Health;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;Human;Hydrophobicity;improved;in vivo;Inotropism;Kinetics;Knock-in;Knock-in Mouse;Knock-out;L-Type Calcium Channels;loss of function;Macromolecular Complexes;Measures;Mediating;member;Modeling;Modification;Molecular;Monomeric GTP-Binding Proteins;Mouse Strains;Mus;Myocardial Contraction;novel;novel therapeutics;Pathologic;Patients;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;phosphoric diester hydrolase;Phosphorylation;Pilot Projects;Preparation;protein complex;Receptor Signaling;Regulation;response;Risk;Risk Reduction;Safety;Sarcomeres;sensor;Signal Pathway;Signal Transduction;Slice;stoichiometry;Structural Models;Structure;success;Sympathomimetics;Testing;Therapeutic;Therapeutic Uses;translational potential;United States;voltage;Work

PROJECT_TITLE: Mechanisms of L-type Calcium Channel Regulation in Heart Health and Disease

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: NORTH DARTMOUTH

ORG_NAME: UNIVERSITY OF MASSACHUSETTS DARTMOUTH

PHR: PROJECT NARRATIVE: Current antiretrovirals, although effective in controlling HIV-1 infection, do not cure the disease. Antiretroviral drugs blocking essential functions of the viral protein Nef, if developed successfully, may revitalize immune de- fense mechanisms and thus open up the possibility for a cure. This project is designed to develop such an- tiretroviral therapeutics in a novel and promising format, namely cyclic peptides.

PI_NAMEs: FASAN, RUDI ;GUATELLI, JOHN C.;JIA, XIAOFEI  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adaptor Signaling Protein;Adopted;Affinity;Amino Acids;analog;Animal Model;Anti-Retroviral Agents;antibody-dependent cell cytotoxicity;Antigen Presentation;Binding;Biochemical;Biological Assay;Biological Availability;Biological Models;Biophysics;CD4 Positive T Lymphocytes;Cell membrane;Cell Physiology;Cell surface;Cells;Cellular biology;Clathrin;Clathrin Adaptors;Complex;Cyclic Peptides;Cyclization;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Defense Mechanisms;Derivation procedure;design;Detection;Development;Disease;Doctor of Philosophy;Dose;Down-Regulation;drug discovery;enhancer-binding protein AP-2;env Gene Products;Epitopes;Experimental Designs;Goals;high throughput screening;HIV-1;Host Defense Mechanism;Human;Immune;Immunologic Receptors;improved;In Vitro;in vivo;Infection;inhibitor;insight;Knowledge;Laboratories;Lead;Major Histocompatibility Complex;Measures;Mediating;mimetics;Modality;Molecular Conformation;nef Genes;nef Protein;novel;Patients;Penetration;Peptides;peptidomimetics;Permeability;Phage Display;Pharmaceutical Preparations;Play;Posture;protein function;protein protein interaction;rational design;recruit;Resolution;Role;screening;Series;Site;small molecule;small molecule libraries;Structure;success;Surface;synergism;T-Lymphocyte;Tail;Testing;Therapeutic;Toxic effect;Transcription Factor AP-1;unnatural amino acids;Viral;Viral Pathogenesis;Viral Physiology;Virus;Virus Replication;Work

PROJECT_TITLE: Developing Cyclopeptide Nef Inhibitors to Facilitate HIV-1 Eradication


NIH_SPENDING_CATS: Cancer;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The goal of this proposal is to investigate the role of the stroma and its crosstalk with the cancer cell in lineage plasticity and therapy resistance and to identify new non-oncogenic vulnerabilities to be targeted therapeutically. We will test the hypothesis that the loss of PKCλ/ ι upregulates a CD44/Hyaluronan axis that induces the mesenchymal phenotype, characterized by epithelial EMT and the generation of a desmoplastic tumor stroma, both critical events for tumor progression and therapy resistance.

PI_NAMEs: DIAZ MECO CONDE, MARIA TERESA (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Adenocarcinoma;androgen independent prostate cancer;Androgen Receptor;Appearance;Applications Grants;atypical protein kinase C;Automobile Driving;Back;cancer cell;cancer type;Carcinoma;CD44 gene;Cell Reprogramming;Cells;Classification;Clinical;Cues;Data;design;Desmoplastic;Development;Developmental Process;effective therapy;enzalutamide;Epithelial Cells;Epithelium;Event;Extracellular Matrix;Feedback;Generations;Genes;Goals;Human;Hyaluronan;Hyaluronidase;Hybrids;In Vitro;in vivo;Laboratories;Ligands;Malignant neoplasm of prostate;Mesenchymal;Metabolism;Modeling;Molecular;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neuroendocrine Tumors;Neurosecretory Systems;non-oncogenic;novel;novel therapeutics;Pathway interactions;Patient Selection;Phenotype;Population;Predisposition;pressure;programs;Property;Prostate;prostate cancer cell;prostate cancer progression;Prostatic Neoplasms;Publishing;Regulation;Resistance;response;Role;Signal Transduction;single-cell RNA sequencing;stem;stem cells;stem-like cell;stemness;targeted treatment;Testing;Therapeutic;therapeutic target;therapy design;therapy resistant;trait;tumor;Tumor Cell Invasion;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Work

PROJECT_TITLE: Role of the CD44/Hyaluronan axis in mesenchymal prostate cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) drug development relies on both mouse and clinical research, but translational resources to bridge the gap between mouse and human AD are limited. Building upon my previous research creating the mouse Hippocampus Gene Expression Atlas (HGEA), this proposal will investigate translational gene expression patterns across hippocampal neuronal cell types in mouse AD models and humans (with and without AD). The completion of this research will produce a comprehensive human HGEA that, together with the mouse HGEA, can help guide AD drug development and reveal the hippocampal neuronal cell types that are primarily affected by AD.

PI_NAMEs: BIENKOWSKI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Anatomy;Animal Behavior;Animal Experimentation;Anterior;Architecture;Atlases;Autopsy;Behavior;Behavioral Symptoms;Binding;Brain;Brain region;career;career development;cell type;Cells;Cerebral cortex;Chromosome Mapping;Clinic;Clinical;Clinical Research;comparative;connectome;Data;digital;Disease;drug development;effective therapy;Ensure;experience;experimental study;Failure;Foundations;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;hippocampal atrophy;hippocampal pyramidal neuron;hippocampal subregions;Hippocampus;Human;human disease;In Situ Hybridization;Individual;insight;Investigation;K-Series Research Career Programs;Laboratories;Laboratory Study;Lead;Link;Magnetic Resonance Imaging;Maps;medial temporal lobe;Mentors;Mentorship;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropathology;Neurosciences;Optics;Output;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;receptor;Research;Research Personnel;Resources;Rodent;Scientist;Severities;side effect;Spatial Design;species difference;success;Symptoms;theories;Thick;Tissues;tool;Training;transcriptome;transcriptomics;Transgenic Mice;Translating;translational neuroscience;web site;Work

PROJECT_TITLE: A Translational 3D Map of Hippocampal Cell Types To Drive Investigations of Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Social Determinants of Health

ORG_CITY: NORTHRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: This study will provide important empirical evidence regarding the impact of senior centers on healthy  aging and potential disparities in aging-related resources to inform policy and decision making related to aging.  Furthermore, this study will offer direct implications to parks and recreation and public health agencies on how  to design and plan the amenities and programs/services at senior centers to achieve optimal health outcomes  for older adults.

PI_NAMEs: XIE, HUI  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Administrator;Adult;Affect;age group;Aging;aging population;aging related;American;Attitude;baby boomer;Bachelor's Degree;Behavior;Biomedical Research;California;Cities;Communities;Data;Decision Making;Dedications;design;Disparity;Elements;Environment;Environmental Risk Factor;Equipment;experience;fitness;Frequencies;Funding;Gender;Generations;Geography;graduate student;Guidelines;Health;healthy aging;human old age (65+);Individual;Influentials;Knowledge;Lead;Leisures;Master of Science;Mental Health;Mentors;older adult;Outcome;Perception;Personal Satisfaction;Phase;physical conditioning;Physical environment;Policy Maker;Policy Making;Population;programs;Public Health;Recreation;Research;Research Assistant;Research Contracts;Research Project Grants;Resources;Role;Sampling;Scientist;Secure;Senior Scientist;Services;social;Social Environment;Socioeconomic Status;Source;Statistical Data Interpretation;Students;Subgroup;Surveys;Time;Training;trend;Underrepresented Populations;United States;United States National Institutes of Health;Variant;Visit;Walking

PROJECT_TITLE: Senior Centers and Older Adults' Health Outcomes


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Successful completion of the experiments listed in this proposal will characterize, in detail, the Clostridioides difficile spore small acid soluble proteins. These proteins contribute to the extreme resistance properties that are characteristic of endospores, C. difficile included. By understanding how C. difficile spores maintain their resistance to genotoxic chemicals / treatments, a better strategy to reduce their burden in the healthcare environment can be designed.

PI_NAMEs: SORG, JOE  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acids;adduct;Affect;Alleles;Amino Acids;antibiotic-associated diarrhea;Bacillus subtilis;Bacteria;Binding;Binding Proteins;Biology;Cells;Characteristics;Chemicals;Chromosomes;Clostridium;Clostridium difficile;Clostridium perfringens;cost;crosslink;Data;Desiccation;design;Development;dimer;Disease;DNA;DNA Binding;DNA Sequence;Endospore-Forming Bacteria;Environment;Event;experimental study;extreme temperature;Formaldehyde;Future;Gel;Genes;Genetic Transcription;Genome;genotoxicity;Germination;Hamsters;health care settings;Healthcare;Healthcare Systems;Hospitals;Hydrogen Peroxide;In Vitro;Individual;Infection;Life;Lyase;Metabolism;Minor;Modeling;Mothers;mutant;Mutation;Nature;Nitrous Acid;novel;Organism;Oxygen;Pathogenesis;Patients;Peptide Hydrolases;Phase;Phase-Contrast Microscopy;Phenotype;Physiology;Polymerase;prevent;Process;Production;programs;Property;Proteins;Publishing;repaired;Reproduction spores;Resistance;Role;Site;Source;Specificity;Structure;Surface;Testing;Thymidine;Time;Toxin;transmission process;ultraviolet damage;Ultraviolet Rays;Ultraviolet Therapy;United States;UV induced DNA damage;UV Radiation Exposure;UV sensitive;whole genome;Work

PROJECT_TITLE: Impact of the C. difficile small acid soluble proteins on spore physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-N(80)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology Project Narrative New insights from genome sequencing and technical advances in genome editing, chemical biology, and cellular engineering are providing unprecedented opportunities for advances in cancer treatment. The emerging complexity of cancer biology and increasing sophistication of experimental therapeutics demand a level of understanding and training in research methodology beyond the scope of conventional fellowship programs. To address these challenges, the goal of the Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology (DF/HCC K12) is to recruit and select a highly qualified and diverse group of Scholars to complete a rigorous two-three year program of didactic instruction and mentored research that will prepare them for independent careers in clinical oncology research.

PI_NAMEs: CHABNER, BRUCE ALLAN;GRAUBERT, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advisory Committees;Appointment;career;career development;clinical investigation;Clinical Investigator;Clinical Medicine;Clinical Oncology;Clinical Trials;Dana-Farber Cancer Institute;Data Science;Development;Development Plans;Discipline;equity, diversity, and inclusion;Faculty;faculty mentor;Funding;Goals;Grant;Industry;Institution;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Monitor;next generation;Oncology;Output;Performance;Physicians;Population Sciences;Positioning Attribute;Productivity;Program Development;programs;Progress Reports;Publications;Qualifying;Recommendation;Records;recruit;Request for Applications;Research;Research Personnel;Role;Science;Scientist;Training;Woman;Work

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]