NIH_SPENDING_CATS: Clinical Research;Lung;Pediatric

ORG_CITY: DETROIT

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative No study has been performed to prospectively record the presenting complaints, signs, symptoms and comorbidities of children who raised the suspicion of pulmonary embolism (PE) in children. This lack of evidence puts children in jeopardy by causing both under diagnosis and over testing. Project BEEPER will assimilate the first ever multicenter prospective dataset that will allow better detection of PE in children and the potential to exclude PE without need for diagnostic testing.

PI_NAMEs: ELLISON, ANGELA M;KLINE, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Accident and Emergency department;Adolescent;Adult;Age;aged;Angiography;Applied Research;Autopsy;cancer risk;Caring;Case Fatality Rates;Child;Child Care;Child Health;Chronic Disease;Clinical;clinical practice;clinical predictors;comorbidity;Confidence Intervals;Data;Data Set;Death Rate;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Sensitivity;Diagnostic tests;Disease;Emergency Care;evidence base;Exclusion;Exposure to;Fibrin fragment D;follow-up;Health Personnel;Heart Rate;high risk;Hospitals;Image;improved;Indwelling Catheter;Infection;Injury to Kidney;Intravenous;Ionizing radiation;Lung;Medical;Metabolic syndrome;Methods;Modification;novel;older patient;Outcome;Outpatients;patient subsets;Patients;pediatric emergency;Physicians;Prevalence;Probability;Process;prospective;prospective test;Pulmonary Embolism;pulmonary symptom;Radiation;Radiation exposure;Research;Retrospective Studies;Risk;Safety;Sample Size;Scanning;Sensitivity and Specificity;Signs and Symptoms;Specificity;Symptoms;Techniques;Testing;treatment as usual;Work;X-Ray Computed Tomography

PROJECT_TITLE: BEdside Exclusion of Pulmonary Embolism in children without Radiation (BEEPER)

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: NR

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Patient-centered communication is associated with improved health-related quality of life and has been recognized as essential to high-quality gynecologic cancer care. The proposed research will refine and pilot test a novel, scalable intervention to promote patient-centered communication in ovarian cancer care. Further, the proposed research will address the need for efficient and accurate methods to identify patient-centered communication behaviors by assessing the feasibility of using natural language processing to analyze transcripts of audio-recorded clinic visits.

PI_NAMEs: POZZAR, RACHEL  (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Address;Adherence;Aftercare;arm;Behavior assessment;cancer care;cancer recurrence;career development;Caregivers;Caring;Categories;Characteristics;Clinic Visits;Clinical;Clinical Trials;Clinical Trials Design;Code;Communication;communication behavior;Complex;Dana-Farber Cancer Institute;Data;design;Development;Development Plans;Documentation;efficacy trial;Emotional;Emotions;Enrollment;expectation;experience;Feasibility Studies;Fostering;Goals;Health;health related quality of life;Health Technology;Human;implementation science;improved;improved outcome;Individual;innovation;Intervention;Interview;Leadership;Libraries;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuals;Measurement;Measures;medical schools;meetings;Mentors;Methods;Mission;Modeling;National Institute of Nursing Research;Natural Language Processing;novel;Nurses;Outcome;Outcome Measure;Outcomes Research;Participant;patient oriented;Patients;person centered;Personal Satisfaction;physical symptom;pilot test;Postdoctoral Fellow;preference;prevent;Process;Protocols documentation;provider behavior;psychological distress;Public Health Schools;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Resources;Roter;Sampling;Scientist;Self Efficacy;skills;social;Specificity;Surveys;Survival Rate;System;Systems Analysis;Text;Training;Transcript;treatment as usual;trial comparing;usability;Visit

PROJECT_TITLE: Development and Pilot Testing of a Collaborative Agenda-Setting Intervention to Promote Patient-Centered Communication in Ovarian Cancer Care

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(84)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Malaria control is contingent upon interrupting transmission of the Plasmodium parasite by the mosquito vector. This project studies how processes triggered by blood feeding and leading to oogenesis affect Plasmodium falciparum development in the female Anopheles gambiae mosquito, the most important malaria vector. These studies will considerably increase our understanding of biological processes crucial to transmission of malaria and will generate new concepts that will inform current and future control strategies.

PI_NAMEs: CATTERUCCIA, FLAMINIA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acceleration;Affect;Africa;Africa South of the Sahara;Anopheles gambiae;Anopheles Genus;Apoptosis;Biological Process;Biology;Blood;Burkina Faso;Cell Physiology;Cellular Assay;Cessation of life;Coupled;Culicidae;Data;Development;Ecdysterone;egg;Event;feeding;Female;field study;Future;Genetic;Genetic Determinism;Genetic Polymorphism;Genotype;Goals;Growth;Hepatocyte;Homeostasis;Human;Impairment;Incubated;Individual;Infection;Ingestion;Interruption;Invaded;Investigation;Investments;Knowledge;life span;Link;lipid transport;Lipids;lipophorin;Lipoprotein (a);Malaria;malaria transmission;male;Measures;Mediating;Metabolic;Midgut;Modeling;novel;Nuclear Receptors;Oocysts;Oogenesis;Output;Ovary;Oxidative Stress;Parasites;Pathway interactions;Periodicity;Physiological;Physiological Processes;Plasmodium;Plasmodium falciparum;Population;pressure;Process;Reproduction;reproductive;reproductive fitness;Reproductive Process;RNA Interference;Role;Salivary Glands;Shapes;Signal Transduction;Sporozoites;steroid hormone;Time;Tissues;transcriptome sequencing;transmission process;vector;vector control;vector mosquito

PROJECT_TITLE: Determining the interactions between mosquito oogenesis and Plasmodium falciparum survival and transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Diabetes and associated diseases are major health concerns in today’s society. The proposed research is relevant to the mission of the NIDDK because it examines the therapeutic tractability of SWELL1 modulators for the treatment of Type 2 diabetes. Exploring this therapeutic approach and testing a series of SWELL1 modulators will expand our understanding of novel therapeutic avenues and delineate an innovative target for the treatment and prevention of diabetes.

PI_NAMEs: SAH, RAJAN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Anti-diabetic Drugs;B-Lymphocytes;Beta Cell;Binding;Biology;blood glucose regulation;Blood Pressure;Body System;Cardiac;cardiovascular effects;Cardiovascular system;Cartoons;Cell membrane;Chemicals;Chronic;Complex;Cryoelectron Microscopy;Data;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;Diabetic mouse;Disease;Docking;Dose;Drug Delivery Systems;efficacy clinical trial;efficacy study;euglycemia;Event;experimental study;fasting glucose;Fatty acid glycerol esters;Fatty Liver;Generations;Glucose;Glucose Intolerance;glucose production;glucose tolerance;glucose uptake;Health;heart function;hemodynamics;Hepatic;Human;Hypoglycemia;Impairment;improved;In Vitro;in vivo;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;insulin signaling;intraperitoneal;islet;Knockout Mice;Laboratories;Lead;Lipids;Liver;loss of function;man;Mediating;Metabolic;Metabolic syndrome;meter;Mission;Modeling;Molecular;Molecular Chaperones;Mus;Myocardium;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Oral;patch clamp;Pharmaceutical Preparations;pharmacologic;pre-clinical;Property;protein expression;Proteins;Regimen;Research;response;Risk;Series;Signal Pathway;Signal Transduction;simulation;Site;Skeletal Muscle;small molecule;Societies;Structure;Structure of beta Cell of islet;Structure-Activity Relationship;Sulfonylurea Compounds;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;tool;trafficking;Treatment Efficacy;Vertebral column

PROJECT_TITLE: Optimizing small molecule SWELL1-LRRC8 modulators to treat Type 2 diabetes


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project narrative The proposed research will provide critical information about effective Medicaid policies to improve health care utilization of Medicaid enrollees with opioid use disorder (OUD) and reduce the number of opioid-related overdoses among them. This knowledge will help inform state Medicaid policymakers who are seeking effective approaches in improving treatment for OUD among their Medicaid enrollees.

PI_NAMEs: LINDNER, STEPHAN REINHARD (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: addiction;Address;Affect;Beds;Behavior Therapy;beneficiary;Buprenorphine;care coordination;Caring;Case Management;Cessation of life;Clinical;contextual factors;Counseling;Data;Data Collection;Data Set;Death Rate;design;Disease;effectiveness evaluation;Elements;Eligibility Determination;Emergency Situation;Enrollment;Fibrinogen;flexibility;Funding;General Hospitals;Health;health care service utilization;Healthcare;hospital utilization;Hospitals;improved;Individual;Information Systems;Inpatients;insight;Institution;Intensive Care;Interview;Knowledge;Laws;Medicaid;Medicaid services;Mental Health;Methadone;Methods;Naltrexone;Natural experiment;Office Visits;Opioid;opioid abuse;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;optimal treatments;Outcome;Outpatients;Patients;Persons;Pharmaceutical Preparations;Play;Policies;Policy Maker;Process;programs;Provider;Psyche structure;Public Health;Public Policy;Relaxation;Research;Residential Facilities;response;Role;service utilization;Services;Severities;Substance abuse problem;substance use;substance use treatment;Time;treatment guidelines;treatment services;United States;United States Centers for Medicare and Medicaid Services;waiver

PROJECT_TITLE: The Effects of States' Substance Use Waivers on Healthcare Utilization and Opioid-related Overdoses Among Medicaid Enrollees with Opioid Use Disorder

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE RNA viruses encompass both established and emerging pathogens, many of which cause significant morbidity and mortality worldwide and remain a constant threat to global public health, with antiviral therapies lacking for many of these viruses. The proposed study will define a new regulator of how the host senses RNA virus infection and activates the antiviral defense program, as well as defining how viruses use this new regulator for immune evasion. This study will reveal new targets that may be harnessed for the development of novel antiviral and immune therapeutics designed to limit viral infection, viral-mediated disease, and autoimmune disease.

PI_NAMEs: HORNER, STACY MICHELLE (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Anti-viral Response;Anti-viral Therapy;antiviral immunity;Autoimmune Diseases;Biological Response Modifiers;Cell Physiology;Cells;Complex;Data;Dengue Infection;Dengue Virus;design;Development;Disease;emerging pathogen;Flavivirus;Genes;Goals;Human Cell Line;Immune;Immune Evasion;Immune system;Immunotherapeutic agent;improved;Infection;innate immune pathways;Innate Immune Response;innovation;Interferons;IRF3 gene;Knowledge;Ligase;Lysine;Mediating;Membrane;Molecular;Molecular Chaperones;monocyte;Morbidity - disease rate;mortality;Natural Immunity;novel;Pathway interactions;Pattern recognition receptor;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;prevent;Process;programs;protein function;protein phosphatase inhibitor-2;Proteins;Public Health;Receptor Signaling;Regulation;response;RNA Virus Infections;RNA Viruses;Role;Signal Pathway;Signal Transduction;Signaling Protein;System;TBK1 gene;Testing;Therapeutic;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;vaccine strategy;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work;ZIKA

PROJECT_TITLE: Regulation of RIG-I signaling and viral immune evasion by ufmylation

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MERCED

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

ORG_STATE: CA

PHR: We propose a graduate research training program in Interdisciplinary Biomedical Science and Technology (I-BioSTeP) at the University of California Merced, a Hispanic-serving institution that opened in 2005. The major objective of this program is the establishment of the first doctoral level graduate training program at UC Merced in the biomedical sciences to train diverse cohorts of students to identify and solve pressing biological problems using quantitative interdisciplinary approaches that prepare them for competitive careers in the biomedical field. There are many unique aspects of our proposed program that specifically address our objectives including the diversity of our current student body and applicant pool that we target for recruitment, a core interdisciplinary curriculum of courses with lab components, a summer bridge program that addresses retention by bringing students out two months before classes and immersing them in hands-on training, mentoring and professional development such as fellowship proposal writing, an interdisciplinary multiple mentor structure, and a unique career development program that focuses on specific skills that are important in the biomedical research workforce such as business/entrepreneurial skills and science communication skills.

PI_NAMEs: GOPINATHAN, AJAY  (contact);LIWANG, ANDY ;MUNOZ, VICTOR

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: G-RISE at UC Merced

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Precision Medicine

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Radiation metabolomics is a well-established field in biomarker discovery and in assessing changes associated with metabolic perturbations, whether in tissues or biofluids. We have developed a rich database of radiation biomarkers in urine, blood, and saliva and we now plan to develop multiplex assays that are highly quantitative and can serve as the first step towards a deployable assay using commercially based instruments. Additionally, we will further develop membrane-based technologies that will aim to eliminate the pre-processing steps, thereby jump-starting the sample processing step and enrichment for specific classes of metabolites and stabilizing the biosignature during transport. !

PI_NAMEs: LAIAKIS, EVAGELIA CHRISTOS (contact);ZENHAUSERN, FREDERIC

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Automation;Binding;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biosignature;Blood;Blood specimen;Clinical;Clinical Research;cohort;Communities;comparison control;cost efficient;Databases;Dependence;design;Development;Devices;Dose;Dryness;Emergency Situation;Engineering;Environment;Evaluation;Exhibits;experience;experimental study;Exposure to;flexibility;Funding;Future;Gel;Generations;Goals;Human;human error;Individual;Injury;instrument;Intention;Intervention;Ionizing radiation;Laboratories;liquid biopsy;Liquid Chromatography;manufacture;mass casualty;Medical;medical countermeasure;Membrane;Metabolic;metabolomics;Methods;Modeling;multiplex assay;Mus;new technology;Noise;nonhuman primate;novel;Phase;predictive panel;Preparation;preservation;Process;prototype;Radiation;Radiation Accidents;Radiation exposure;Radiation Injuries;radiation-induced injury;Radiology Specialty;rapid technique;Readiness;Reproducibility;Research;Resources;response;Saliva;saliva sample;Sampling;Serum;Signal Transduction;Solid;Specificity;stability testing;System;tandem mass spectrometry;targeted biomarker;Techniques;Technology;technology development;technology platform;Temperature;Testing;Textiles;Time;Tissues;urinary;Urine;Validation;virtual;Whole Blood

PROJECT_TITLE: Targeted Biomarker Panels and Pre-processing Device for the Rapid Assessment of Radiation Injury in Easily Accessible Biofluids


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Acute alcohol intoxication is a robust predictor of intimate partner violence (IPV) perpetration for young adult men and women; therefore, interventions delivered proximally to drinking episodes – a period of high risk – are needed to reduce alcohol-facilitated IPV. This project seeks to improve public health by delivering a just-in-time text messaging intervention proximally to drinking episodes and evaluating the impact of the intervention on alcohol-facilitated IPV in a sample of at-risk young adult men and women. Additionally, through an innovative design this project is poised to answer these important questions: whether receiving a message, when, for whom, what type, and under what conditions this just-in-time messaging intervention leads to reductions in alcohol use and IPV perpetration.

PI_NAMEs: STAPPENBECK, CYNTHIA A. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Acute;adaptive intervention;Aggressive behavior;Alcohol consumption;alcohol intervention;alcohol involvement;Alcoholic Intoxication;Alcohols;Anger;Arousal;Baseline Surveys;behavioral health;Caring;Categories;Cellular Phone;comparison control;Conflict (Psychology);Consumption;contextual factors;cost;COVID-19 pandemic;design;Disinhibition;distress tolerance;drinking;efficacy evaluation;emotion regulation;Emotional;Evaluation;experience;follow-up;Future;Goals;Heavy Drinking;heavy drinking young adult;High Prevalence;high risk;improved;Individual;innovation;Intervention;intervention effect;intimate partner violence;Mediating;Mediation;men;mobile computing;Modeling;Monitor;negative affect;novel;Outcome;pandemic disease;Participant;Persons;Pilot Projects;Process;programs;psychologic;Public Health;Randomized;randomized trial;Recording of previous events;reduced alcohol use;Reporting;Research;Resources;response;Risk;Sampling;sex;sexual assault;skills;Surveys;Technology;Testing;Text Messaging;text messaging intervention;theories;Time;treatment arm;trial design;verbal;violence perpetration;web-based intervention;Woman;young adult

PROJECT_TITLE: Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) During normal conception as well as with the use of artificial reproductive technologies, a receptive uterus is key to a successful pregnancy, but it is not known what makes a uterus structurally competent for implantation. We have developed a technology to visualize and analyze the mouse uterus in three-dimensions during conception and establishment of pregnancy and we observe dynamic changes in the uterine structure that correlate to the rising levels of progesterone. This proposal will address the effects of progesterone and the embryo itself on endometrial structure, thus providing novel structure based insights into uterine receptivity during assisted reproduction and in conditions of subfertility.

PI_NAMEs: ARORA, RIPLA  (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: 3-Dimensional;Affect;Animals;assisted reproduction;Biological;blastocyst;Clinical;Computing Methodologies;Conceptions;confocal imaging;Defect;Development;early pregnancy;egg;Embryo;Endometrial;Endometrium;Environment;Epithelium;Estrogens;fertility improvement;Fetal Growth;Fetal Growth Retardation;Genetic;Goals;Health;healthy pregnancy;Hormonal;Hormones;Human;human subject;Image Analysis;implantation;improved;inhibitor;Inner Cell Mass;insight;Knowledge;Location;Luteal Phase;Mammalian Oviducts;Menstrual cycle;Methods;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;natural Blastocyst Implantation;novel;novel strategies;nutrient absorption;Organ;Outcome;Ovarian hormone;Ovarian Hyperstimulation Syndrome;Pathologic;Pathway interactions;Patients;Pattern;Phase;Physiological;Placental Insufficiency;Play;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy loss;Pregnancy Outcome;pregnant;Premature Birth;Preparation;Progesterone;public health relevance;receptor;Reproductive Technology;Research;Role;Saline;Serum;Shapes;Signal Pathway;Signal Transduction;Source;Spontaneous abortion;Stimulus;Structure;subfertility;success;Superovulation;Technology;Testing;three dimensional structure;Three-Dimensional Image;Time;Tissues;uterine receptivity;Uterus;Visualization;WNT5A gene;Woman

PROJECT_TITLE: Signaling mechanisms that modulate uterine 3D structure for pregnancy success

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Autoimmune and autoinflammatory diseases afflict 7-9% of the world population, and the goal of this project is to understand how the cytosolic cGAS/STING DNA sensing pathways contributes to these potentially devastating diseases so that we can better control them. This project draws on investigators with complementary expertise and will apply exciting new tools and strategies to study how innate immune responses in non-hematopoietic cells can promote lung complications. Insights resulting from this project should give us an opportunity to develop better treatment strategies for the many patients who suffer from interstitial lung disease.

PI_NAMEs: FITZGERALD, KATHERINE A. (contact);MARSHAK-ROTHSTEIN, ANN

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Alleles;Apoptosis;Area;Autoimmune;Autoimmune Diseases;autoinflammation;autoinflammatory;autoinflammatory diseases;Autophagocytosis;Binding;Cell Death;cell type;Cells;chemokine;Chronic;Cyclic GMP;cytokine;Data;design;Development;Disease;DNA;effector T cell;EIF-2alpha;Endothelial Cells;Endothelium;Event;Fibroblasts;gain of function mutation;Gene Expression;Genetic Transcription;Goals;Heterozygote;IFNAR1 gene;Immune;in vivo;infancy;Infection;Inflammation;Inflammatory;inhibitor;innate immune function;Innate Immune Response;insight;Interferon Type II;Interferons;Interstitial Lung Diseases;IRF3 gene;Lead;Lesion;Link;Lung;Lung Diseases;Lymphocyte;Lymphocyte Depletion;Mediating;Mediator;Modality;mouse model;Mus;Mutation;Myeloid Cells;novel;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Play;Population;Process;Production;pseudotoxoplasmosis syndrome;PTPRC gene;radioresistant;Rag1 Mouse;receptor;recruit;Research;Research Personnel;Respiratory Failure;response;Reticular Cell;Rheumatoid Arthritis;Role;Series;severe COVID-19;Signal Transduction;Stimulator of Interferon Genes;STING-associated vasculopathy;Stromal Cells;Systemic Scleroderma;T cell infiltration;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;TBK1 gene;Therapeutic;tool;treatment strategy;type I interferon receptor

PROJECT_TITLE: Mechanisms of STING-driven autoinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Primary Health Care;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: A Mental Health Implementation Research Training Program will continue to prepare scientists to develop effective and feasible mental health interventions that are adapted to a specific culture and context, making more efficient use of less specialized human resources available in various low-resource systems of care that can help increase access to effective treatments and reduce the mental health treatment gap. In Mozambique, an expanding mental health service infrastructure will require implementation science research guiding the implementation and scale up of evidence-based interventions capable of reaching those often excluded from care. As a clear leader in the Portuguese speaking African countries (PALOP – Países Africanos de Língua Oficial Portuguesa), Mozambique can be a model to other PALOP and sub-Saharan African countries as well as other to low-resource settings, including the US, and thus help decrease the global mental health research and treatment gap.

PI_NAMEs: NOORMAHOMED, EMILIA VIRGINIA;OQUENDO, MARIA A;WAINBERG, MILTON L (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;African;Brazil;Caring;Clinical;Collaborations;Community Health Aides;Computerized Medical Record;Counseling;Country;Disease;Doctor of Philosophy;eHealth;Evidence based practice;Face;Faculty;Fogarty International Center;Funding;Funding Opportunities;Goals;hands on research;Health Personnel;Health Technology;implementation research;implementation science;Individual;International;Investments;Journals;large datasets;Leadership;Medical;Mental disorders;Mental Health;Mental Health Services;Mentors;mHealth;motivational enhancement therapy;Mozambique;National Institute on Alcohol Abuse and Alcoholism;novel;Persons;Pharmaceutical Preparations;Policies;Portuguese;Primary Care;primary care provider;Program Sustainability;programs;Psychiatrist;Psychologist;Public Health;Public Health Informatics;Publications;recruit;Research;Research Personnel;Research Training;response;Safety;scale up;Strategic Planning;substance use;Substance Use Disorder;suicidal risk;Training;Training Activity;United States National Institutes of Health;Woman

PROJECT_TITLE: PALOP Mental Health Implementation Research Training


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The overarching scientific premise of this application, which is a competing renewal application of an NIA-funded R01 (AG060737), entitled the “Wisconsin Longitudinal Study-Initial Lifetime’s Impact on ADRD (WLS-ILIAD)”, is to evaluate how the accumulation of social advantage and adversity over the full life course impacts risk and resilience against Alzheimer’s Disease and Related Dementias (ADRD). This project began tracking AD and related dementia onset in 2019 as WLS participants reached ~age 80, and would continue into the proposed grant period, thus building an invaluable and uniquely comprehensive dataset to allow for us—and our broader user base—to characterize the AD biomarkers, cognitive, social, behavioral, and medical profile of participants at risk or resilient to dementia.

PI_NAMEs: ASTHANA, SANJAY  (contact);ENGELMAN, MICHAL ;HERD, PAMELA

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;African American;Age;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Attention;Back;base;Behavioral;behavioral health;Biological;Biological Markers;Biological Sciences;Birth;Black race;Blood;blood-based biomarker;Brain scan;caregiving;Censuses;Cerebrospinal Fluid;Clinic;Clinical;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Collection;Communities;cost;Data;Data Set;Dementia;dementia risk;Disease;Economics;Education;Employment;ethnic difference;ethnic diversity;Ethnic Origin;Ethnic Population;Exposure to;family support;follow-up;Funding;Gender;gender difference;global health;Goals;Grant;Health;Healthcare;inattention;Indigenous;Individual;insight;Life;Life Cycle Stages;Link;Long-Term Care;Longitudinal cohort study;Longitudinal Studies;Measures;Medical;men;Nature;novel;older adult;Participant;participant enrollment;Pathology;Persons;physical conditioning;Plasma;Population Study;Positron-Emission Tomography;predictive marker;Process;prospective;Protocols documentation;Race;racial difference;racial diversity;racial population;Random Allocation;Records;Research;resilience;Resources;response;Risk;Sampling;Sampling Studies;sex;Shapes;social;Social Conditions;social health determinants;social relationships;Social Sciences;Social support;socioeconomics;Symptoms;tau Proteins;United States National Institutes of Health;Variant;Visit;Wisconsin;Woman;Work

PROJECT_TITLE: Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Commensal microbes are already perfectly suited for safe and effective colonization of various physiological niches; what remains is to take advantage of their incredible genomic plasticity and ability to function as robust biochemical factories. This project will develop human commensal microbes as vehicles for delivery of therapeutic compounds directly to the site of disease in the gastrointestinal tract. To achieve this, we will engineer gut bacteria to produce and secrete targeted biological therapeutics such as antibody fragments in situ, with the goal of addressing critical issues in human health, including antibiotic resistance, toxicity, and rapid response to emerging threats.

PI_NAMEs: SIRK, SHANNON JULIANNE (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Formation;Area;Bacteria;Bacterial Proteins;Biochemical;biological development;Biological Response Modifier Therapy;Bypass;Clostridium difficile;Coculture Techniques;Collection;combinatorial;commensal bacteria;commensal microbes;Communicable Diseases;Communities;Complex;cost;delivery vehicle;Disease;Ecosystem;Engineering;Engraftment;Ensure;Extracellular Space;Fermentation;fitness;flexibility;Food;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;Gastrointestinal tract structure;Gene Expression;Genetic;genetic manipulation;Genomics;Germ-Free;Goals;Growth;gut bacteria;gut microbes;gut microbiota;Health;Human;Human body;human microbiota;Immunoglobulin Fragments;In Situ;In Vitro;in vitro activity;in vivo;Infection;insight;Intravenous;Knowledge;Lactobacillus casei;Measures;metabolic engineering;Metabolism;Microbe;microbial;microbial community;Modeling;Mus;neutralizing antibody;Oral;Oral Administration;Passive Immunity;pathogen;pathogenic microbe;Pathogenicity;Performance;Physiological;Plasmids;Probiotics;Production;protein expression;Protein Secretion;Proteins;Recombinant Proteins;Resistance;Resources;response;Site;Source;Specificity;Support System;synthetic biology;System;targeted delivery;targeted treatment;Technology;Testing;Therapeutic;Therapeutic antibodies;Time;Tissues;tool;Toxic effect;tumor

PROJECT_TITLE: Targeted Delivery of Therapeutics by Engineered Commensal Microbes

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The Boston Area Diabetes and Endocrinology Research Center (BADERC) provides high quality, cutting-edge and cost-effective technical support to investigators performing research related to diabetes mellitus in the Boston area. It also provides an Enrichment Program and seed grants for diabetes-related research, a resource that has been avidly sought by area investigators. The existence of the Center facilitates multidisciplinary and inter-institutional collaboration as well as multiple training opportunities.

PI_NAMEs: SOUKAS, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Academic Medical Centers;Academic support;Address;Area;Autoimmunity;Bioinformatics;Blood Vessels;Boston;Cellular biology;Clinical;clinical investigation;Clinical Investigator;Collaborations;Communication;Communities;cost effective;Dana-Farber Cancer Institute;Development;Diabetes Mellitus;Direct Costs;Education;Endocrinology;energy balance;Ensure;Etiology;experience;Fostering;General Hospitals;Genes;genetic architecture;Genomics;Graft Rejection;Grant;Hospitals;Image;Immunologics;Institution;Insulin;Insulin Resistance;inter-institutional;International;Israel;Knowledge;Laboratories;macrovascular disease;Massachusetts;Medical center;medical schools;Medical Students;Metabolic;metabolomics;Methods;Molecular;Molecular Genetics;Monitor;multidisciplinary;Neurobiology;New England;optimal treatments;Pathogenesis;Patient Care;Pediatric Hospitals;Physiology;Productivity;programs;Proteomics;Public Health Schools;repository;Research;Research Institute;Research Personnel;Resources;Scientist;Services;Talents;Teaching Hospitals;Training;training opportunity;trait;Transgenic Animals;Translational Research;type I and type II diabetes;Update;web site;Woman


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: FLOREZ, JOSE CARLOS (contact)

PROJECT_TERMS: Area;Articulation;Award;Biomedical Research;Boston;Collaborations;Consultations;Diabetes Mellitus;Discipline;Endocrinology;equity, diversity, and inclusion;Funding;General Hospitals;Goals;Grant;Hospitals;Institution;inter-institutional;Israel;Massachusetts;Medical center;Medicine;Monitor;new technology;Open Reading Frames;operation;Pediatric Hospitals;Policies;programs;quality assurance;Recommendation;Research;Research Personnel;Resources;Science;senior faculty;service delivery;success;Update;web site;Woman

PROJECT_TITLE: Admin Core


PI_NAMEs: BROWN, DENNIS  (contact)

PROJECT_TERMS: Address;Antibodies;Area;Attention;Award;base;Biological;Blood Vessels;Boston;Cells;Cellular biology;cellular imaging;Cellular Immunology;Cellular Metabolic Process;Communication;Communities;community center;Competence;Confocal Microscopy;Core Facility;data management;Data Reporting;design;Diabetes Mellitus;Electron Microscopy;Endocrinology;Endothelial Cells;Ensure;Environment;Equipment;experience;Floor;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Funding;Genetic;Goals;Grant;high resolution imaging;Human Resources;Image;imaging approach;Imaging Techniques;Immunofluorescence Immunologic;Incubated;Individual;Institution;instrumentation;Islet Cell;Journals;Laboratories;Lasers;Maintenance;Medicine;Membrane Biology;Membrane Proteins;Microdissection;Microscopy;Morphology;Nature;Procedures;programs;Protocols documentation;Publications;Qualifying;Quality Control;real-time images;recruit;Reporting;Reproducibility;Research;Research Personnel;Resources;Science;Signal Transduction;stem cells;Structure;success;System;Targeted Research;Technical Expertise;Techniques;Temperature;Time;trafficking;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Cell Biology Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Usher Syndrome

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE Pathogenic variants in the USH2A gene are the most prevalent causes of autosomal recessive retinitis pigmentosa and Usher syndrome, the leading cause of inherited deaf-blindness. Due to technical limitations of viral mediated gene delivery, conventional gene augmentation therapy is not amenable for treating USH2A- related disorders. This project aims to explore and evaluate the therapeutic potentials of CRISPR/Cas9-based gene editing strategies for correcting or repairing the pathogenic variants in the USH2A gene.

PI_NAMEs: LIU, QIN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Abbreviations;adeno-associated viral vector;Affect;Alternative Splicing;Alternative Therapies;Amino Acids;Animals;Antisense Oligonucleotides;autosome;base;base editing;base editor;Bilateral Hearing Loss;Biological Assay;Biological Process;Birth;Blindness;Cell Line;Cells;Clinical Research;Code;Complement;CRISPR/Cas technology;Deafblind;Dependovirus;Disease;DNA;emerging adult;Europe;Event;Excision;exon skipping;exon skipping therapy;Exons;Frameshift Mutation;gene augmentation therapy;Gene Delivery;gene editing technology;gene therapy;gene-editing approach;Genes;Genetic;genetic approach;Genome;Goals;hearing impairment;Human;humanized mouse;improved;in vivo;Individual;induced pluripotent stem cell;Inherited;inherited retinal degeneration;innovative technologies;intein;interest;Knockout Mice;Mediating;Medical;Mendelian disorder;Modality;mouse model;Mus;mutant;Mutate;Mutation;mutation correction;Nonsense Mutation;novel therapeutics;nuclease;Open Reading Frames;Organoids;Orthologous Gene;Pathogenicity;Patients;Persons;Phase I/II Clinical Trial;Phenotype;Pilot Projects;preclinical study;prevent;prevent hearing loss;prime editing;prime editor;protein complex;Proteins;Reading Frames;repaired;Reporting;Research;Retina;Retinitis Pigmentosa;RNA Splicing;Safety;Site;Splice-Site Mutation;success;System;Technology;Testing;Therapeutic;therapy development;tool;Transcript;treatment strategy;USH2A gene;Usher Syndrome;Usher Syndrome Type 2;Variant;Viral;Vision;Work;Zebrafish

PROJECT_TITLE: CRISPR/Cas9-based gene editing approaches for the treatment of USH2A-associated diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


PI_NAMEs: KAHN, BARBARA B. (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Area;awake;Biological;blood glucose regulation;Body Composition;Body measure procedure;Body Temperature;Body Weight decreased;Bone Density;Boston;Carbon Dioxide;Cell model;Cells;Communities;Continuous Glucose Monitor;design;Diabetes Mellitus;Dose;Dual-Energy X-Ray Absorptiometry;Eating;Endocrinology;energy balance;Ensure;Equipment;experience;experimental study;Fatty Acids;Feedback;gene product;Genes;Genetic Vectors;Genomics;Glucose;glucose metabolism;glucose transport;glucose uptake;Goals;Grant;Homeostasis;In Vitro;in vivo;Indirect Calorimetry;Insulin;Insulin Resistance;insulin sensitivity;Knock-in;knockout gene;lipid metabolism;Lipids;Lipolysis;Measurement;Measures;member;Metabolic;metabolic rate;Metabolism;metabolomics;Mission;Modeling;mouse model;Mus;Obesity;overexpression;Oxygen Consumption;Pathway interactions;Phenotype;Physical activity;Physiology;Production;Proteomics;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Resolution;respiratory;response;Rodent Model;Role;Services;Surveys;Techniques;Technology;tool;Training and Education;Triglycerides;United States National Institutes of Health;Viral Vector;Weight Gain

PROJECT_TITLE: Metabolic Physiology and Energy Balance Core


ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This renewal proposal seeks support for our T32 Fellowship program, now in its 40th year, for physician- scientist training in infectious diseases (ID) at UC San Diego (UCSD), now to be titled: “CARING: Combating Antibiotic Resistance into the Next Generation.” Physician-Investigators receive intensive leading-edge basic and translational research training in the world-class labs of prolific mentors deploying innovative approaches to confront the global antibiotic resistance crisis. This experience is integrated with formal, high quality career development activities to ensure successful advancement of fellows in academic ID medicine.

PI_NAMEs: NIZET, VICTOR  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Antibiotic Resistance;next generation

PROJECT_TITLE: Combating Antibiotic Resistance Into the Next Generation (CARING)

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


PI_NAMEs: ROSEN, EVAN D (contact)

PROJECT_TERMS: Address;Adopted;Algorithms;Antibodies;Area;ATAC-seq;Binding;Binding Sites;Bioinformatics;Biological;Boston;Cell Communication;Cells;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Client;community center;Complex;Consultations;cost;Data;Data Analyses;data quality;Data Set;data sharing networks;data visualization;Databases;Deposition;Development;Diabetes Mellitus;Diagnosis;differential expression;droplet sequencing;Education;Endocrinology;Enhancers;Ensure;Event;Experimental Designs;experimental study;functional genomics;Generations;Genes;genome browser;genome-wide;Genomics;Goals;Individual;Instruction;Laboratories;Libraries;member;Metabolic Diseases;Methods;mindfulness;new technology;next generation sequencing;Nuts;Obesity;operation;Pathway Analysis;Preparation;Process;promoter;Protocols documentation;Quality Control;Research;Research Personnel;Risk;Sampling;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Split-Pool Ligation Transcriptome sequencing;System;Techniques;Technology;Testing;Tissues;transcription factor;transcriptome sequencing

PROJECT_TITLE: Genomics and Bioinformatics Core


ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses our basic understanding of membrane trafficking, a process that controls the localization of cell surface receptors and their signaling, mitochondrial homeostasis, ciliogenesis, centrosome duplication and cell division, and a host of other key cellular events. Accordingly, enhancing our knowledge of these processes is likely to lead to new opportunities to improve human health, consistent with the mission of the National Institutes of Health.

PI_NAMEs: CAPLAN, STEVEN H (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Actins;Address;Back;Binding Proteins;Biochemistry;Biogenesis;Biological;Biological Process;Cell division;Cell membrane;Cell Surface Receptors;Cellular biology;Centrosome;Cilia;cilium biogenesis;Collaborations;Complex;Coupled;Cytoplasmic Tail;Cytoskeleton;Degradation Pathway;Destinations;endosome membrane;Endosomes;Eukaryotic Cell;Event;genetic regulatory protein;Golgi Apparatus;Health;Homeostasis;Human;improved;in vivo;Knowledge;Laboratories;late endosome;light microscopy;Link;Lysosomes;Mammalian Cell;Mediating;Membrane;Mission;Mitochondria;Molecular;Pathway interactions;Process;protein function;Proteins;Public Health;receptor;receptor internalization;receptor recycling;Recycling;Regulation;Research;Research Personnel;Retrieval;scaffold;Signal Transduction;Sorting;sorting nexins;trafficking;Tubular formation;United States National Institutes of Health;Vesicle;Whole Organism;Zebrafish

PROJECT_TITLE: Mechanisms of membrane trafficking in endocytic and non-endocytic pathways

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Relevance: Entry of a virus into host cells, which can occur at different subcellular locations, is the first and essential step in virus infection. The goal of the proposed research is to determine how HIV-1, which causes AIDS, enters its natural host CD4+ T cells and thus establishes productive infection. Knowledge obtained from the proposed studies will help us develop novel antiviral strategies that may inhibit spread of this virus to uninfected host cells.

PI_NAMEs: KING, PHILIP D;ONO, AKIRA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Binding;Biology;Capsid;CCR5 gene;CD4 Positive T Lymphocytes;Cell fusion;Cell Line;Cell membrane;Cell Nucleus;Cell Physiology;Cell surface;cell type;Cells;Clathrin;Complex;CXCR4 gene;Cytoplasm;Data;Endocytosis;env Glycoproteins;Environment;Event;experimental study;Genes;Genetic;Goals;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;Immunology;improved;Infection;Knowledge;Laboratories;Location;Mediating;Metabolism;Microscopic;Molecular;Molecular Conformation;N-terminal;Nature;novel;Outcome;particle;Pathway interactions;Peptides;permissiveness;pharmacologic;Play;Process;Productivity;Property;receptor;receptor binding;Reporting;Research;Role;Signal Transduction;small molecule;Surface;T-Cell Activation;T-Lymphocyte;Testing;Viral;Virion;Virus;Virus Diseases

PROJECT_TITLE: Roles of Macropinocytosis in HIV-1 infection of CD4+ T Cells


NIH_SPENDING_CATS: Clinical Research;Diabetes;Nutrition

PROJECT_TERMS: Area;Award;base;Basic Science;Bioinformatics;Boston;career;career development;Catalysis;Categories;Cells;Cellular Metabolic Process;Climate;Clinical;Clinical Research;Collaborations;Consultations;Creativeness;Data;Development;Diabetes Mellitus;diversity and inclusion;Endocrinology;Environment;Evolution;Exposure to;follow-up;Fostering;Foundations;Funding;Funding Opportunities;Goals;Grant;high risk;Industry;innovation;insight;Investigation;Investments;Journals;K-Series Research Career Programs;Knowledge;Learning;Measures;Medicine;Metabolism;Mission;Nature;New England;Newsletter;next generation;nutrition;Obesity;Paper;Peer Review;Pilot Projects;Principal Investigator;Process;Productivity;programs;Publications;Publishing;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;sabbatical;Science;Scientist;Secure;skills;success;symposium;Talents;Therapeutic;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: P&F program


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative/Relevance We propose to develop a transmembrane sensor nanoarray platform that, if successful, will allow rapid, ultrasensitive, and specific detection and quantification of exosomal micro-RNA at the level of single exosomes. We will design Aampanying isothermal signal amplification strategies to detect the low abundance of nucleic acid biomarkers in exosomes. If successful, the proposed work will provide scientists, physicians, and clinicians with a means for rapid, ultrasensitive, highly-specific, cost-effective prognosis and diagnosis of cancer patients without surgical tissue biopsies.

PI_NAMEs: HARIADI, RIZAL FAJAR;YAN, HAO  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;amplification detection;Basic Science;Biological Assay;Biological Markers;biomarker selection;Biopsy;Blood;Body Fluids;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Patient;Cancer Prognosis;cancer therapy;Cell Communication;Cell Line;Cells;Clinical;clinical diagnostics;clinical translation;Consumption;cost effective;Cytolysis;Data;density;design;Detection;detection sensitivity;Development;Devices;Diagnosis;Diagnostic;diagnostic biomarker;Differential Diagnosis;digital;Disease;DNA;Encapsulated;exosome;Fluorescence;Heterogeneity;Human Milk;improved;Individual;interest;Investigation;isothermal amplification;Legal patent;liquid biopsy;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Messenger RNA;Methods;Microarray Analysis;microRNA biomarkers;MicroRNAs;Microscopy;Miniaturization;Molecular;Monitor;Nanoarray Analytical Device;nanosensors;Neoplasm Metastasis;Nucleic Acids;Operative Surgical Procedures;Optics;pancreatic cancer patients;Patients;Pattern;Physicians;Plasma;Positioning Attribute;Primary Neoplasm;Procedures;Process;Prognosis;Prognostic Marker;Proteins;Quantitative Reverse Transcriptase PCR;rapid detection;Reaction;Reporting;Research;Resources;RNA;Role;Saliva;Sample Size;Sampling;Scientist;screening;Sensitivity and Specificity;sensor;Serum;Signal Transduction;single molecule;skills;Solid;Specificity;stoichiometry;Surface;Technology;Testing;Time;Tissue Sample;Tissues;Treatment Efficacy;tumor heterogeneity;tumor progression;Tumor Tissue;tumorigenesis;Urine;Vesicle;Work

PROJECT_TITLE: High-throughput, purification-free, and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: FPIES is a non-IgE-mediated food allergy with unknown pathophysiology, and the only diagnostic test is an oral food challenge performed in a hospital setting which can result in severe symptoms. In this project, we propose a new low-dose multi-day food challenge protocol that we anticipate will generate milder symptoms, and will release mucosal T cells into the periphery for high dimensional single-cell analysis. This clinical and mechanistic study will improve care for patients with FPIES by improving diagnostics and revealing novel immune pathways of disease.

PI_NAMEs: BERIN, CECILIA  (contact);NOWAK-WEGRZYN, ANNA HALINA

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Adenosine;Allergic;antagonist;antigen challenge;antigen-specific T cells;Antigens;Biological Markers;Biopsy;Blood;Caregivers;Celiac Disease;Cell Separation;Cells;Chronic;Clinical;Collection;Critical Pathways;cytokine;Cytometry;Diagnosis;Diagnostic;Diagnostic tests;Diarrhea;Disease;Disease Pathway;Dose;Double-Blind Method;Emergency Situation;Endoscopy;Enterochromaffin Cells;Evaluation;Food;food antigen;food challenge;Food Hypersensitivity;Food Protein-Induced Enterocolitis Syndrome;Frequencies;Functional disorder;gastrointestinal;gastrointestinal symptom;Gastrointestinal tract structure;Gluten;Health Services Accessibility;high dimensionality;Home;Hospitals;Hour;Human;Immune;immune activation;Immune response;immunoregulation;Improve Access;improved;Individual;infancy;Ingestion;Intravenous;IV Fluid;Link;Liquid substance;Mediating;metabolomics;Monitor;Mucous Membrane;Nature;novel;Ondansetron;Oral;Participant;Pathway interactions;Patient Care;Patients;peripheral blood;Phenotype;Plasma;primary outcome;Proteins;Protocols documentation;Provider;purine metabolism;Purines;Purinoceptor;Randomized;Reaction;receptor;Recording of previous events;Reflex action;Regulation;Resolution;Resources;response;Resuscitation;Role;safety assessment;Serotonin;Severities;Shock;single cell analysis;single-cell RNA sequencing;Sorting;Symptoms;T-Cell Activation;T-Lymphocyte;Testing;Tissues;transcriptome sequencing;Vomiting

PROJECT_TITLE: Immune Basis of FPIES

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(57)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative Among the 2.4 million Americans living with chronic HBV (HBV), Asian Americans are disproportionately impacted with the highest rates of HBV infection and liver cancer. Through this multilevel, longitudinal study, we will leverage our existing partnerships with Regional Cancer Health Disparities Networks of CBOs and clinical partners to examine the impact of structural racism and discrimination on HBV screening and linkage to care among Asian American ethnic groups: Chinese, Korean, and Vietnamese. Findings will inform the development of culturally appropriate, multilevel SRD interventions to improve quality of care and reduce Hepatitis-related liver disease and cancer disparities.

PI_NAMEs: MA, GRACE X. (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Adult;Advanced Malignant Neoplasm;Advocacy;Affect;African American population;American;anti-Asian;Asia;Asian;Asian Americans;barrier to care;Black race;cancer diagnosis;cancer health disparity;Caring;Chinese;Chronic Hepatitis B;Cities;Clinical;Communities;community based participatory research;community collaboration;community organizations;Community Surveys;COVID-19;COVID-19 pandemic;Crime;Data;Data Analyses;Data Collection;Death Rate;density;Detection;Development;Diagnosis;Disadvantaged;Discrimination;disease disparity;Disparity;Ethnic Origin;Ethnic Population;Federally Qualified Health Center;Funding;Goals;hate crimes;Health;health care availability;health care settings;Health Care Surveys;Health Disparities Research;health disparity;Health Services Accessibility;Health system;Hepatitis;Hepatitis B;Hepatitis B Infection;Hepatitis B Prevalence;Hepatology;high risk;Immigrant;Immigration;improved;Incidence;Individual;Inequality;Infection;infection risk;innovation;Institution;Institutional Racism;Insurance;Intervention;Interview;Koreans;Latinx;Linguistics;Link;Lived experience;Liver diseases;Longitudinal Studies;Low income;Malignant neoplasm of liver;Methods;Modeling;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;Neighborhoods;Not Hispanic or Latino;Organizational Policy;Outcome;patient navigator;Patients;perceived discrimination;Philadelphia;Play;poor health outcome;Population;population based;Poverty;primary health center;Procedures;protective factors;Provider;Public Health;Quality of Care;Race;racial bias;racial disparity;racial population;racism;Recommendation;Recording of previous events;Regional Cancer;Research;residence;residential segregation;resilience;Resources;Role;screening;segregation;Services;Shapes;social;social cohesion;social norm;Stereotyping;structural determinants;Structural Racism;Surveys;systematic review;theories;therapy design;Trauma;United States National Institutes of Health;United States Preventative Services Task Force;uptake;Vietnamese;Work

PROJECT_TITLE: Impact of Structural Racism and Discrimination on Liver Disease Disparities in High-Risk Asian American Populations


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Sleep Research

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Sleep is beneficial to learning in early childhood, which leaves open the question of why children transition out of naps at such a critical developmental time for learning. The overarching objective of this proposal is to understand how maturation of the brain during early childhood results in more information being retained without interference, reducing the need for frequent consolidation that takes place during naps. Such information has translational and theoretical significance, enhancing understanding of the mechanisms underlying sleep regulation and the consequences of sleep on health.

PI_NAMEs: RIGGINS, TRACY L. (contact);SPENCER, REBECCA M C

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;Age;Anatomy;Area;awake;Biological Markers;biomarker identification;Brain;Brain region;Child;Childhood;Cognitive;cognitive development;Data;Data Set;design;Development;Diffusion;Discrimination;early childhood;Ecological momentary assessment;evidence base;forgetting;Health;Hippocampus;Human;innovation;insight;Intervention;Investigation;Learning;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Memory;memory consolidation;memory process;Modeling;Monitor;Napping;neural;novel;Outcome;Parents;Participant;Pattern;Performance;Phase;Physiological;Polysomnography;predictive marker;pressure;rapid growth;recruit;Reporting;Research;Risk;Science;sex;Sleep;Sleep Architecture;sleep physiology;sleep regulation;Structure;Synapses;Testing;theories;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative: Offspring of obese mothers have a high risk of asthma later in life, but the mechanism of this occurrence is unclear. This study will investigate changes in airway nerve function and innervation, both leading to the development or exacerbation of asthma, in offspring of obese mothers, and the role of insulin in these changes.

PI_NAMEs: MALOYAN, ALINA ;NIE, ZHENYING  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acetylcholine;Adult;Adult Children;afferent nerve;Afferent Neurons;Age;airway epithelium;airway hyperresponsiveness;Animals;Architecture;Asthma;asthma exacerbation;autonomic nerve;Avil;Bronchoconstriction;Child;Chimeric Proteins;cholinergic;confocal imaging;Data;Development;Diet;Epithelium;Exposure to;Fasting;Fetus;Glucose Intolerance;High Fat Diet;high risk;Human;Hyperinsulinism;Image;Image Analysis;in vivo;innovation;Insulin;Insulin Receptor;Knock-out;Life;maternal obesity;Measures;Mediating;Metabolic;methacholine;Methods;microscopic imaging;Modeling;Molecular;Mothers;mouse model;Mus;Muscarinic M2 Receptor;Muscle function;Nerve;nerve supply;neural;Neurites;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;Neurotransmitters;novel;Obese Mice;obese mothers;Obesity;obesity-associated asthma;offspring;Optics;optogenetics;Patients;Peripheral;pharmacologic;Pharmacology;Physiology;Population;Positioning Attribute;Prevention;receptor expression;receptor function;Reflex action;Reporting;Research;respiratory smooth muscle;Role;Sensory;Serotonin;Severity of illness;Smooth Muscle;Structure;Substance P;Techniques;Testing;Thinness;Three-Dimensional Image;Tissues;Umbilical Cord Blood;Vagotomy;Weaning;Woman

PROJECT_TITLE: Mechanisms of airway hyperresponsiveness in the offspring of obese mothers

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Genetics;Human Genome;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The zebra finch courtship song shows striking similarities to human speech, and the zebra finch system provides a well-controlled animal model with exceptional behavior to understand the neural circuit mechanisms of vocal learning and motor control. We will develop next generation connectomics and spatial transcriptomics methods to simultaneously measure connectivity, gene expression, and activity of single neurons in the zebra finch song control system during singing. The proposed research paves the way for future R01 applications investigating the role of diverse HVC neurons in producing acoustic structure in the brain and is relevant to NIH's mission by furthering our understanding of the neuronal mechanisms underlying skilled motor behaviors.

PI_NAMEs: KEBSCHULL, JUSTUS M (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Acoustics;Address;Adult;Animal Model;Bar Codes;Behavior;Behavior Control;Behavioral;Biological Models;Brain;BRAIN initiative;Brain Mapping;Brain region;Brain Stem;Cell Nucleus;cell type;Cells;Collaborations;Communication;Complement;Complex;Courtship;Data;Development;DNA sequencing;Electrophysiology (science);experimental study;flexibility;Fostering;Foundations;Functional Imaging;Future;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Histologic;Human;Image;In Situ;in situ sequencing;in vivo;in vivo imaging;Individual;insight;Investigation;Knowledge;Laboratory mice;Learning;Link;male;Maps;Measurement;Measures;Methods;Microscope;Mission;model organism;Modeling;Motor;motor behavior;motor control;Motor Skills;multimodality;multiple omics;Multiplexed Analysis of Projections by Sequencing;Names;neural circuit;Neurons;next generation;novel;Nucleic Acids;Optical Methods;Output;Pattern;preservation;Production;Property;Prosencephalon;Research;Resolution;RNA;Role;Sampling;single-cell RNA sequencing;Songbirds;Speech;stem;Structure;support tools;System;Techniques;Technology;Testing;Tissue imaging;Tissues;tool;transcriptomics;Translating;tutoring;two-photon;United States National Institutes of Health;Update;Virus;vocal learning;Work;zebra finch

PROJECT_TITLE: Integrating single-cell connectivity, gene expression, and function in zebra finches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N(55)R]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Our project will develop methods for the nonparametric estimation of heterogenous treatment effects (HTEs). We will (1) develop methods for HTEs that vary with baseline variables, (2) develop HTE methods for IV designs, and for time-varying effects, and (3) we will apply the methods to three original applications.

PI_NAMEs: KEELE, LUKE  (contact);KENNEDY, EDWARD H.

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Abdomen;Age;Benchmarking;Binding;care outcomes;Caring;Clinical;clinical prognosis;Clinical Research;Comparative Effectiveness Research;comparative effectiveness study;Complex;Computer software;Confidence Intervals;Data;design;Development;Dimensions;dosage;Educational workshop;Effectiveness;Emergency Situation;Endometrial Carcinoma;Ensure;experience;flexibility;Healthcare;Heterogeneity;high dimensionality;Hospital Nursing;improved;individualized medicine;innovation;interest;Intervention;Machine Learning;machine learning framework;machine learning method;Masks;Measures;Methods;Modeling;non-compliance;novel;Observational Study;Operative Surgical Procedures;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Population;Positioning Attribute;Property;Publishing;Race;randomized trial;Research;Research Personnel;Risk;Sample Size;semiparametric;simulation;software development;Software Tools;Statistical Methods;study population;Subgroup;Testing;theories;Time;tool;treatment effect;treatment strategy;Variant;Work

PROJECT_TITLE: Efficient nonparametric estimation of heterogeneous treatment effects in causal inference

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Aging of the heart is a major health care concern for Americans. This project studies the effects of specific proteins that can regulate cellular growth in the heart and aims to understand molecular mechanisms of these proteins.

PI_NAMEs: LEE, RICHARD T (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Affect;age related decline;American;Amino Acid Sequence;Amino Acids;Biochemical;Biochemistry;Biological Markers;Blood;cardiac aging;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;cell growth;Cessation of life;Clinical Data;cohort;Collaborations;Coronary;Coronary heart disease;CRISPR/Cas technology;Data;Differentiation and Growth;Disease;Event;experimental study;extracellular;functional outcomes;Future;GDF11 gene;GDF8 gene;Genetically Engineered Mouse;genomic locus;Growth;Healthcare;Heart;heart dimension/size;Heart Diseases;heart function;Heart Hypertrophy;Hospitals;Human;Human Biology;human data;human disease;In Vitro;in vivo;insight;interest;Laboratories;laboratory experiment;Ligands;loss of function mutation;MADH2 gene;Maintenance;Mass Spectrum Analysis;Measurement;Measures;member;Molecular;morphogens;mortality;Mus;Muscle Development;Muscle function;Myocardial;Myocardium;Outcome;outcome prediction;Pathway interactions;Patients;Phenotype;Physiological;Physiology;pressure;prospective;Proteins;Publishing;Receptor Signaling;Role;Signal Pathway;Signal Transduction;Skeletal Development;Structural Biochemistry;Structure;System;Systems Development;Techniques;Testing;Transforming Growth Factor beta;Translating;Universities;Woman;X-Ray Crystallography

PROJECT_TITLE: Myocardial Physiology of Growth Differentiation Factor Signaling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Cardiovascular;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Approximately one quarter of Americans have elevated plasma triglyceride levels, which are a risk factor for heart disease. We aim to enhance the activity of lipoprotein lipase, the enzyme that clears triglycerides from the blood, by blocking its inhibitors.

PI_NAMEs: NEHER, SASKIA  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Active Sites;Adverse effects;Affect;American;angiogenesis;Angiopoietins;ANGPTL3 gene;ANGPTL4 gene;base;Binding;Biogenesis;Biological;Blood;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cells;Complex;Cryoelectron Microscopy;Data;design;dimer;Drug Design;Enzymes;Excision;extracellular;Family;follow-up;Funding;Genetic;Grant;Heart Diseases;Heparin;Image;improved;Individual;inhibitor;Investigation;Kinetics;Knowledge;Lead;Lipase;Lipoprotein Binding;lipoprotein lipase;lipoprotein lipase inhibitor;Lipoproteins;loss of function mutation;Molecular;Molecular Chaperones;Molecular Weight;N-terminal;nanobodies;novel;novel therapeutics;Peptides;peptidomimetics;Plasma;preservation;prevent;Production;Productivity;Property;Proteins;Reporting;Request for Proposals;Resistance;Risk Factors;Roentgen Rays;Role;screening;Secretory Vesicles;Serum;Structure;Structure-Activity Relationship;success;Surface;Tertiary Protein Structure;Therapeutic;therapeutic target;trafficking;Triglycerides;Variant;Vesicle;wound healing;X-Ray Crystallography

PROJECT_TITLE: Investigation of the Molecular Mechanisms of Lipoprotein Lipase Inhibitors

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Gene Therapy;Genetics;Regenerative Medicine;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Islet transplantation replaces the lost insulin-producing pancreatic islet beta cells due to type 1 diabetes. However, this therapy is not widely used because of its variable efficacy and the requirement for life-long immunosuppression that can lead to a whole host of problems. We will tackle these issues using genetic engineering to help islet to withstand the stress of transplantation and resist immune attacks. The goal is to develop strategy for highly efficient islet transplantation without the need of immunosuppression.

PI_NAMEs: KU, GREGORY MICHAEL;MCMANUS, MICHAEL T;TANG, QIZHI  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Ablation;Address;antagonist;arm;base editing;Beta Cell;beta cell replacement;CD28 gene;Cell Death;cell replacement therapy;Cell Survival;Cells;Cellular biology;Cellular Infiltrate;Cellular Stress;Cessation of life;Chronic;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;CRISPR interference;curative treatments;cytokine;Data;efficacy testing;Engineering;Engraftment;Environment;experience;experimental study;gene-editing approach;Genes;Genetic Engineering;genome editing;Glucose;Goals;high throughput screening;Histocompatibility Antigens Class I;HLA Antigens;Human;humanized mouse;Hypoxia;IFNAR1 gene;IL1R1 gene;Immune;Immune Evasion;immune function;Immune response;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunologics;Immunosuppression;improved;in vivo;Inbred NOD Mice;Individual;Inflammation;Inflammatory;Insulin;Insulin-Dependent Diabetes Mellitus;intercellular cell adhesion molecule;Interferons;Interleukin-1;Intervention;Ischemia;ischemic injury;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Knowledge;Laboratories;Mediating;Metabolic;Modality;mouse model;novel;nutrient deprivation;overexpression;Pancreas;Pathway interactions;prime editing;Research;revascularization;Risk;RNA Interference;RNA interference screen;Screening procedure;Secondary to;somatic cell gene editing;stem cells;Stress;Structure of beta Cell of islet;synthetic biology;Systems Biology;Testing;Tissues;TNF gene;TNFRSF1A gene;Toxic effect;trafficking;Transplantation;Transplantation Immunology;Treatment Efficacy;vascular bed;Vascular blood supply;Vascular regeneration;Vascularization;Vision;Work

PROJECT_TITLE: Genome editing of human pancreatic islets to withstand ischemic injuries and promote immune evasion

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Tight regulation of coenzyme A (CoA), a cofactor that plays a key role in energy metabolism, is essential to maintain normal organ function and is achieved by balancing its synthesis and degradation. CoA degradation is a poorly characterized process and the research proposed herein will determine the importance of two CoA- degrading enzymes, Nudt19 and Nudt8, in the regulation of the CoA pools and CoA-dependent metabolic pathways within peroxisomes and mitochondria, respectively. This knowledge will establish the potential of targeting CoA-degrading enzymes to manipulate specific subcellular CoA pools and correct deranged metabolic processes with more selectivity.

PI_NAMEs: LEONARDI, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acyl Coenzyme A;acyl group;Biochemical;Biochemical Pathway;Cholesterol;Coenzyme A;cofactor;Cytosol;Development;Energy Metabolism;Enzymes;Exercise;fatty acid oxidation;Funding;genetic manipulation;Gluconeogenesis;Goals;histone modification;Kidney;Knowledge;lipid metabolism;Liver;Mammalian Cell;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial metabolism;Mus;Organ;Organelles;Pathway interactions;Performance;peroxisome;Play;Post-Translational Protein Processing;Postabsorptive Hypoglycemia;prevent;Prevention;Process;programs;Property;Publishing;Reaction;reduced muscle mass;Regulation;Renal function;Research;Role;Skeletal Muscle;Tissues

PROJECT_TITLE: Changes in Coenzyme A Levels are a Key Mechanism Regulating Metabolic Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

PHR: NARRATIVE Maternal morbidity and mortality in sub-Saharan Africa are driven by causes that are largely preventable with early recognition and timely interventions. Easy-to-use, wearable, continuous physiological monitoring devices could increase access to care and improve outcomes for postpartum women in low-resource settings. In this application, I propose a series of related studies to evaluate the feasibility and implementation of postpartum physiologic monitoring to prevent severe maternal morbidity and mortality.

PI_NAMEs: SPELKE, MAE BRIDGET  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Adherence;Administrator;Adoption;adverse birth outcomes;Africa South of the Sahara;African;Agreement;antenatal;Area;Attention;Blood Pressure;blood pressure control;care delivery;care outcomes;career;career development;Characteristics;Child;Childbirth;clinical epidemiology;clinical phenotype;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Country;Data;design;digital;digital health;Discipline of obstetrics;Education;effectiveness/implementation trial;Eligibility Determination;Ensure;Epidemiology;Equity;Evaluation;experience;Family;feasibility trial;Fogarty International Center;follow-up;Foundations;Frequencies;Future;future implementation;global health;Goals;Gynecologist;Health;health application;Health Services Accessibility;Health Technology;Heart Rate;Hemorrhage;high risk;High Risk Woman;Home;hospital readmission;Hospitals;Hour;Hypertension;implementation framework;implementation research;implementation science;improved;improved outcome;Income;Infant;International;Intervention;Intervention Trial;intrapartum;Investigation;K-Series Research Career Programs;Learning;Life;lifetime risk;Maintenance;Maternal Health;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Measures;Medical Records;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Modification;Monitor;monitoring device;Morbidity - disease rate;neglect;North Carolina;novel strategies;obstetric outcomes;Outcome;Oxygen;Participant;Patient Monitoring System;Patients;Physiologic Monitoring;Physiologic pulse;Physiological;Policy Maker;Population;post implementation;postpartum care;postpartum complications;postpartum health;postpartum outcome;Postpartum Period;Postpartum Programs;Postpartum Women;Pregnancy;Pregnant Women;Premature Birth;prevent;Prevention;Procedures;programs;Prospective cohort;Protocols documentation;Provider;Proxy;Qualifying;Qualitative Evaluations;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;remote monitoring;Research;Research Personnel;Resource-limited setting;Resources;respiratory;Risk Factors;Sample Size;sensor;Sepsis;Series;severe maternal morbidity;skills;Solid;System;Technology;Temperature;Time;Training;Universities;uptake;wearable device;wearable sensor technology;wireless sensor;Woman;Women's Health;women's outcomes;Women's study;Zambia

PROJECT_TITLE: A Career Development Award in Global Postpartum Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Intellectual disabilities are group of debilitating conditions causing life-long cognitive and behavioral defects that often remain undiagnosed and untreated. Advances in genetic studies have uncovered that defects in chromatin regulation during cerebral cortex development significantly contribute to the pathogenic mechanisms leading to intellectual disability. Our goal is to uncover the role of the chromatin modifier Enhancer of Zeste Homologue 1 (EZH1) in cortical neurogenesis that will ultimately provide new insights into the mechanisms and treatments for a novel intellectual disability syndrome caused by mutations in EZH1.

PI_NAMEs: AKIZU, NAIARA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Activator Appliances;Adult;Behavioral;Binding;Biological Models;Cell Line;Cell Nucleus;cell type;Cells;cerebral atrophy;Cerebral cortex;Child;Chromatin;Chromatin Remodeling Factor;Cognitive;comparison control;Complex;Data;Date of birth;Defect;design;Development;Developmental Process;Differentiated Gene;Disease;endogenous stem cells;Enhancers;Enzymes;Epigenetic Process;experimental study;EZH2 gene;Functional disorder;gain of function;gain of function mutation;gene repression;Genetic Engineering;Genetic study;Genomics;Goals;Histones;Homeostasis;Homologous Gene;Human;human embryonic stem cell;inhibitor;insight;Intellectual functioning disability;Knock-out;Knowledge;Laboratories;Lifelong disability;loss of function;loss of function mutation;Lysine;Maintenance;Measures;Mediating;Methylation;Methyltransferase;Minor;Molecular;monolayer;Morphology;mutant;Mutation;nerve stem cell;Nervous System;nervous system development;Nervous System Disorder;Neurites;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuronal Differentiation;Neurons;new therapeutic target;novel;Organoids;Pathogenesis;Pathogenicity;Patients;Polycomb;postmitotic;premature;preservation;Prosencephalon;Protocols documentation;recruit;Regulation;Role;self organization;single-cell RNA sequencing;stem cell biomarkers;stem cell fate specification;stem cell proliferation;Syndrome;Technology;Testing;Time;Tissue-Specific Gene Expression;Transcription Coactivator;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: The role of EZH1 in neuronal differentiation and neurological disorders

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Currently the identity of dormant but autoagressive CD4+ cells that remain subdued by peripheral tolerance is unknown. In this proposal we will reveal clonal diversity and specificities of autoreactive CD4+ clones entrenched in CD4+repertoire of healthy mice. This research will help us to understand the basis of self-reactivity, revisit the relative significance of thymic and peripheral tolerance, and can lead to the development of new therapeutic protocols to treat autoimmune diseases.

PI_NAMEs: IGNATOWICZ, LESZEK  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Ablation;Acceleration;Agonist;Antigen Receptors;Antigen-Presenting Cells;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive T cell;autoreactivity;Bar Codes;Binding;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;central tolerance;Chromatin;Development;Devices;Diphtheria Toxin;disabled;Epigenetic Process;Gene Targeting;Genomics;high throughput analysis;Homeostasis;Human;Immune response;Individual;Infection;lymphoid organ;Maintenance;Malignant Neoplasms;MHC Class I Genes;MHC Class II Genes;Microfluidics;Modeling;Mus;novel therapeutics;Organ;Pathogenicity;Peptides;Peripheral;peripheral tolerance;prevent;Protocols documentation;Receptor Activation;Receptor Cell;reconstruction;Regulatory T-Lymphocyte;Reproducibility;Research;response;Rest;Role;Self Tolerance;single-cell RNA sequencing;Specificity;Stromal Cells;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;thymocyte;Thymus Gland;Tissues;transcriptome;Transposase;Visit

PROJECT_TITLE: Autoreactive CD4 T cells in healthy mice

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine

PHR: Project Narrative Each year, >300,000 pacemakers are implanted in the U.S. and >900,000 globally. However, current cardiac pacing modalities are largely inadequate for many patients including the pediatric patients with congenital heart disease. We propose to develop bioengineered pacemakers, a paradigm-shifting therapy that is free from all indwelling hardware.

PI_NAMEs: CHO, HEE CHEOL  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Abbreviations;Acute;Animal Model;aortic valve replacement;Atrioventricular Block;Biological;Biological Pacemakers;Biomedical Engineering;Bradyarrhythmias;Cardiac Myocytes;cardiac pacing;Cardiomyopathies;Chronic;Clinical;clinical outcome measures;clinical practice;clinically relevant;comorbidity;congenital heart abnormality;Congenital Heart Block;Congenital Heart Defects;Data;Development;Devices;Disease;Dose;efficacy evaluation;electronic pacemaker;Embryo;Excision;Family suidae;Fibrosis;Foreign Bodies;Gene Delivery;gene therapy;Gene Transfer;Genetic;Goals;Heart Block;Heart failure;Heart Rate;heart rhythm;Implant;implantable device;In Situ;Infection;Investments;Longevity;Longitudinal Studies;Mediating;Messenger RNA;minimally invasive;Modality;Modeling;Molecular;Myocardium;Natural regeneration;new technology;nodal myocyte;Operative Surgical Procedures;Pacemakers;patient subsets;Patients;pediatric patients;porcine model;Positioning Attribute;Procedures;Rattus;regenerative tissue;Research;Rodent Model;Route;Signal Transduction;Sinoatrial Node;Site;Symptoms;Technology;Testing;Time;Tissue constructs;Tissue Engineering;Tissues;trait;Transcend;transcription factor;Transforming Growth Factor beta;transgene expression;Transgenes;Ventricular;Work

PROJECT_TITLE: Heart rate control with bioengineered pacemakers

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Nearly half of adults in the United States have hypertension. Abnormalities in vascular smooth muscle cell Ca2+ signaling mechanisms have been linked to increased arterial contraction and elevated blood pressure in hypertension. We have identified two new Ca2+-signaling pathways in vascular smooth muscle cells that exert opposing effects in the control of blood pressure. The proposed studies will investigate the individual components of these pathways under normal conditions and in hypertension. These studies will advance our understanding of blood pressure regulation by vascular smooth muscle cells and identify novel therapeutic targets for treating elevated blood pressure in hypertension.

PI_NAMEs: SONKUSARE, SWAPNIL K. (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: A kinase anchoring protein;Adrenergic Receptor;Adult;Arteries;Biological Assay;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Calcium Signaling;Caveolae;caveolin 1;Cell membrane;cell type;clinically relevant;Co-Immunoprecipitations;confocal imaging;Contracts;Data;design;Dilator;Electrophysiology (science);Elements;Equilibrium;experimental study;Hypertension;hypertensive;Impairment;Individual;inhibitor;Ion Channel;Knockout Mice;large-conductance calcium-activated potassium channels;Ligation;Link;Measurement;Measures;Mediating;Molecular;mouse model;Mus;Muscle Contraction;Myography;nano;Nerve;new therapeutic target;novel;patch clamp;Pathway interactions;Patients;Peptides;Piezo 1 ion channel;Play;pressure;PRKCA gene;protein activation;Protein Kinase C;Proteins;receptor;Receptor Activation;Receptor Signaling;receptors for activated C kinase;Reporting;Resistance;Rest;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Speed;Stimulus;superresolution imaging;Testing;Therapeutic;United States;Vanilloid;Vascular remodeling;Vascular resistance;Vascular Smooth Muscle;vasoconstriction

PROJECT_TITLE: Novel Calcium Signaling Nanodomains in Vascular Smooth Muscle Cells

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Atherosclerosis, a disease in which lipids build up inside the arterial wall, can lead to serious problems, including heart attack, stroke or even death. Major complications occur when the atherosclerotic artery ruptures and the arteries cannot deliver enough oxygen-rich blood to the heart muscle or brain. The overall goals of this project are to better understand the mechanisms leading to lipid accumulation in the arterial wall and identify new therapeutic targets to mitigate atherosclerosis development and prevent plaque rupture.

PI_NAMEs: CSANYI, GABOR  (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Adopted;Antibodies;Aorta;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;Attenuated;Blocking Antibodies;Blood;Brain;CD36 gene;CD47 gene;Cell Lineage;Cells;Cessation of life;Cre driver;Data;Development;Disease;effective therapy;Female;Fluorescence;Foam Cells;Genetic;genetic approach;Genomics;Goals;high resolution imaging;Human;human morbidity;human mortality;Image;imaging approach;Immunoelectron Microscopy;In Vitro;in vivo;indexing;insight;Knockout Mice;Leukocytes;Ligands;Lipids;Low-Density Lipoproteins;male;Mediating;Membrane;Microscopy;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Myocardium;new therapeutic target;novel;Other Genetics;Oxygen;pharmacologic;Phenotype;Physiological;polymerization;Polymers;prevent;Process;protein aminoacid sequence;Proteins;PTPNS1 gene;receptor;reconstruction;Regulation;Resolution;Role;Rupture;scavenger receptor;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Specificity;Stroke;Techniques;Testing;Therapeutic Intervention;therapeutic target;Thrombospondin 1;tool;transdifferentiation;uptake;Vascular Smooth Muscle

PROJECT_TITLE: SMC macropinocytosis: a novel target in atherosclerotic vascular disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Lung;Lymphatic Research;Rare Diseases;Tuberous Sclerosis

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Mutations in TSC1 or TSC2 genes cause the disease Tuberous Sclerosis Complex in humans that leads to the formation of large tumors in various organs. One of the complications is the accumulation of fluid from lymphatic vessels in the chest cavity, called chylothorax. This proposal will use Tsc knockout mice to investigate the phenotype of the lymphatic vasculature and to identify novel molecular targets in response to Tsc loss-of- function.

PI_NAMEs: YANG, YING  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: absorption;Adverse effects;Affect;Alleles;Apoptosis;Brain;Breathing;Cell Nucleus;cell type;Cessation of life;Chest;Chest Pain;Chronic Disease;Chyle;Chylothorax;Communicable Diseases;Cyst;Data;Development;Diarrhea;dietary;Dietary Fats;Disease;Disease Management;Ear;effective therapy;Embryo;Extravasation;FOXC2 gene;FOXO1A gene;Genes;Genetic;Hamartoma;Human;hypercholesterolemia;Immune;Impairment;Individual;Kidney;knock-down;Knock-out;knockout animal;Knockout Mice;Link;Liquid substance;loss of function;Lung;Lymph;lymph flow;Lymphatic;Lymphatic Capillaries;lymphatic development;lymphatic dysfunction;Lymphatic Endothelial Cells;lymphatic malformations;lymphatic valve;lymphatic vasculature;lymphatic vessel;Mesentery;Molecular;Molecular Target;Mus;Mutation;novel;novel strategies;Nuclear;Oral Ulcer;Organ;Outcome;Pathogenicity;Pathologic;Patient Compliance;Patients;Permeability;Persons;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Pleura;postnatal;prevent;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;Pulmonary Inflammation;Reporting;Respiratory Failure;response;rib bone structure;Risk;Role;shear stress;Signal Pathway;Signal Transduction;Sirolimus;Skin;SLC12A3 gene;small hairpin RNA;Smooth Muscle;Smooth Muscle Myocytes;Symptoms;Tamoxifen;Thinking;Thoracic Duct;Time;Tissues;transcription factor;transcriptome sequencing;TSC1 gene;TSC2 gene;Tuberous Sclerosis;Tuberous sclerosis protein complex;tumor;Western Blotting

PROJECT_TITLE: TSC Proteins in the Lymphatic Vasculature


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

PHR: Project Narrative Metabolic cardiomyopathy progresses to heart failure, one of the leading causes of morbidity and mortality worldwide. This study will address the physiological and molecular functions of important proteins in mediating cardiac triglyceride lipolysis and mitochondrial function. This research will produce broadly applicable, basic biological insights into treatment of metabolic cardiomyopathy.

PI_NAMEs: CHEN, WEIQIN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Adipose tissue;Adult;Age;Binding;Biochemical;Bioenergetics;Biogenesis;Biological;Biological Assay;BSCL2 gene;carboxylesterase;Carboxylesterase 1;Cardiac;Cardiac Myocytes;Cardiomyopathies;Catabolism;Cause of Death;Cells;Clinical;Couples;Coupling;Data;Deposition;Diabetes Mellitus;Diabetic mouse;Diet;disability;Endoplasmic Reticulum;Energy consumption;Energy-Generating Resources;Essential Fatty Acids;Fatty acid glycerol esters;fatty acid oxidation;Functional disorder;Genes;Genetic;Grant;Heart;Heart failure;heart function;Hela Cells;Homeostasis;Human;Hydrolase;Hydrolysis;Image;In Vitro;insight;Ion Transport;knock-down;Knock-in;Knock-in Mouse;Knock-out;Lactamase;Ligation;Link;Lipase;lipid metabolism;Lipids;Lipodystrophy;Lipolysis;Mediating;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial;Myocardial dysfunction;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;overexpression;Pathway interactions;Patients;Physiological;Prevalence;prevent;Process;Production;Proteins;Proteomics;Rattus;reconstitution;Research;Role;Site;Sucrose;System;Testing;Therapeutic;transcriptomic profiling;Triglyceride Metabolism;Triglycerides

PROJECT_TITLE: Novel Role of Bscl2 in Cardiac Substrate Metabolism and Function


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research aims to determine the effects of a whole-diet intervention (the Dietary Approaches to Stop Hypertension (DASH) diet vs. a typical U.S. diet) and lower vs. higher sodium intake on the gut microbiota, the ensemble of microorganisms living in our intestinal tract, and their metabolites (i.e. metabolome) in a randomized controlled feeding trial of racially diverse adults with type 2 diabetes. The study will also assess whether the gut microbiome and metabolome modify, or mediate, the effects of dietary patterns and sodium on blood pressure, thusly helping to inform whether the microbiome can be leveraged for precision nutrition approaches to prevent cardiovascular disease.

PI_NAMEs: MUELLER, NOEL T (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adherence;Adopted;Adult;American Heart Association;Ancillary Study;animal data;Animal Model;Animals;Bacteria;Bioinformatics;Biological;Biological Factors;Biological Markers;Biological Response Modifier Therapy;Black race;Blood;Blood Pressure;blood pressure elevation;blood pressure reduction;Butyrates;Calories;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular risk factor;Cause of Death;clinical practice;Clinical Research;cohort;Communities;DASH diet;Data;Development;Devices;Diet;dietary;dietary adherence;Dietary Factors;Dietary Fiber;Dietary Intervention;Dietary Practices;Dietary Sodium;disorder prevention;dysbiosis;Enrollment;Environment;epidemiology study;Etiology;Eubacterium;Feces;feeding;Fiber;Funding;Guidelines;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Health;Heterogeneity;high risk;high risk population;Human;Hypertension;improved;Individual Differences;Intake;interest;Intervention;Intestines;Measures;Mediating;metabolome;metabolomics;Metagenomics;Microbe;microbial;microbiome;microbiota;microorganism;Modification;mouse model;multi-racial;Mus;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;Outcome;Outcome Measure;Participant;Pathogenicity;Pathway interactions;Pattern;Positioning Attribute;precision nutrition;prevent;Prevention Research;Prevention strategy;Probiotics;Proteobacteria;Public Health;Public Health Schools;racial diversity;Randomized;randomized trial;Recommendation;recruit;Research;Research Design;Research Personnel;Research Project Summaries;response;Role;secondary analysis;Serum;sex variable;Shotguns;Sodium;statistics;Strategic vision;Sum;Testing;Therapeutic;Time;Translating;Volatile Fatty Acids;Weight;whole genome;Whole-Genome Shotgun Sequencing;Work

PROJECT_TITLE: Effects of Dietary Patterns and Sodium Intake on the Gut Microbiome and Metabolome

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: This proposal leverages the Drosophila model system to address the neural mechanisms underlying social interactions, from processing of cues emitted by a communication partner to generating complex behaviors in response to those cues. Impairments in processing sensory information or generating motor behaviors, particularly in the context of social interactions, underlie several human disorders including Parkinson's disease and Autism spectrum disorder. This proposal will uncover general principles of neural circuit function that will inform studies of sensorimotor integration in more complex systems.

PI_NAMEs: MURTHY, MALA  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to Behavior


ORG_CITY: RALEIGH

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE  This proposal will explore the synthesis and application of 1-sulfonylcyclopropanols as stable precursors of chiral cyclopropanone derivatives in the development of biologically relevant synthetic methods, such as rearrangements initiated by the addition of nucleophiles, transition metal-catalyzed C– C activation reactions and radical ring-opening and deconstruction strategies. Moreover, extension of this approach to 1-sulfonylcyclopropylamines and hydrazines as precursors of cyclopropanimines and hydrazones, respectively, is proposed and will allow novel access to chiral amine-containing scaffolds as well as strained chiral carbene equivalents. The preliminary data presented demonstrates that the substrates studied are both more stable yet more reactive than existing cyclopropanone precursors, which have led to the discovery of unprecedented reactivity; this work will lead to novel key synthetic disconnections available for chemists to use in the production of pharmaceuticals and other biologically relevant organic compounds, and in the long-term, to the establishment of cyclopropanone as versatile high-energy intermediate applicable to bio-imaging via ‘click chemistry’.

PI_NAMEs: LINDSAY, VINCENT  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Unlocking Access to Cyclopropanones as Divergent Reactive Intermediates in Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]