ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE  Many environmental carcinogens are agents that damage DNA in target cells, creating characteristic patterns of mutations called “mutational signatures”, which are often found in human tumors. By leveraging a highly-sensitive sequencing technology, this proposal focuses on the development of a blood-based analytical method that can identify environmental carcinogen exposure by their mutational imprints found on circulating cell-free DNA in the blood. The identification of such biomarkers of carcinogen exposure can subsequently guide cancer risk assessment, mitigate further exposure and enable early screening/early detection of cancer in high risk individuals.

PI_NAMEs: FEDELES, BOGDAN I (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acetaminophen;Advanced Development;advanced disease;Aflatoxin B1;Aftercare;Age;analytical method;analytical tool;Animals;Apoptotic;appropriate dose;Bar Codes;base;Benzo(a)pyrene;bioinformatics pipeline;Biological Assay;Biological Markers;Biological Sciences;Blood;blood fractionation;cancer genome;cancer risk;Carcinogen exposure;carcinogenicity;Carcinogens;Cell Cycle Kinetics;Cell Fraction;cell free DNA;Cells;Characteristics;Chemical Exposure;Chemicals;Collection;Consensus;Custom;Data Analyses;design;Development;Dimethylnitrosamine;Disease Progression;DNA;DNA Adducts;DNA Damage;DNA Mutational Analysis;DNA sequencing;early onset;early screening;Environmental Carcinogens;Environmental Exposure;Ethanol;Exposure to;Family;Fingerprint;Future;Genetic;Genome;Genomic DNA;genotoxicity;Goals;Healthcare;Hepatocyte;Hepatotoxicity;hepatotoxin;high risk population;Human;Hybrids;imprint;Incidence;Individual;information gathering;innovation;Intervention;Knowledge;Leukocytes;Libraries;Liver;liver injury;lymph nodes;male;Malignant - descriptor;Malignant neoplasm of liver;Measurement;Measures;Methods;minimally invasive;mouse model;Mus;Mutation;Mutation Analysis;Mutation Detection;Mutation Spectra;N-nitrosodimethylamine;Necrosis;Normal Cell;Organ;Pattern;Plasma;predictive marker;Preparation;prevent;Procedures;Process;Property;Publishing;rapid detection;Reagent;Resolution;Risk Assessment;Screening for cancer;Serum;Single base substitution;Statistical Data Interpretation;success;Technology;Testing;Thymus Gland;Time;Tissue Sample;Tissues;tool;Toxic Environmental Substances;Toxicant exposure;Toxin;Transaminases;tumor;Ultraviolet Rays;Vendor;Work

PROJECT_TITLE: Leveraging mutational analysis of cell-free DNA to identify carcinogenic exposure and enable early detection of cancer

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project narrative Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disorder (MDD). Based on strong preliminary evidence, we seek to investigate a novel non-invasive spinal cord stimulation approach to elucidate the role of SIPs in MDD and their neuromodulation as a novel therapeutic intervention. Results are expected to generate new knowledge on the neurobiology of MDD and a novel approach to study and treat MDD and other psychiatric disorders.

PI_NAMEs: ROMO-NAVA, FRANCISCO  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Adult;Anodes;Autonomic nervous system;Blood Pressure;Brain;brain based;Brain region;C Fiber;Chest;Clinical Trials;cost;Data;Depressive disorder;depressive symptoms;Development;Devices;Dose;Double-Blind Method;Electroencephalography;emotional experience;Evaluation;Evoked Potentials;Exclusion;follow-up;Goals;gray matter;heart rate variability;Homeostasis;Hyperactivity;innovation;Knowledge;Lasers;Link;Major Depressive Disorder;Measures;Mental disorders;Methods;Modeling;neural;Neurobiology;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Peripheral;pharmacologic;Phase;Pilot Projects;predictive modeling;prevent;primary outcome;Process;Reproducibility;Research Design;Resistance;reward processing;Role;Safety;secondary outcome;Severities;sham-controlled study;Signal Pathway;Signal Transduction;Spinal;Spinal Cord;Spinothalamic Tracts;symptomatic improvement;Symptoms;System;Therapeutic;Therapeutic Intervention;therapeutic target;tool;Update

PROJECT_TITLE: Modulating spinal interoceptive pathways to evaluate their role and therapeutic potential in MDD symptomatic domains

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (03)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project narrative  The proposed research is relevant to public health because identifying the components of the cystic fibrosis airway environment that limit the microbicidal activities of immune cells against the main respiratory pathogen in cystic fibrosis, Staphylococcus aureus, is expected to advance our understanding of cystic fibrosis airway inflammation and lay down the groundwork to potentially develop new, immune system-based therapies that can help eliminate S. aureus, or other pathogens in patients of cystic fibrosis, or additional illnesses.  Thus, the proposed research is important to the mission of the NIH by developing fundamental knowledge that will help to fight human diseases.

PI_NAMEs: RADA, BALAZS  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acceleration;Affect;airway inflammation;Antibodies;Antigen-Antibody Complex;antimicrobial;Bacteria;bactericide;Cells;Child;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis sputum;Data;Data Reporting;Disease;Environment;exosome;Exposure to;extracellular;fighting;Foundations;Future;Genetic Diseases;Genus staphylococcus;Goals;granulocyte;Hospitalization;Human;human disease;Immune;Immune system;Immunoglobulin A;Immunoglobulin G;Impairment;In Vitro;Infection;Infectious Agent;Intervention;Knowledge;Link;Lung Diseases;lung injury;Measures;Mediating;methicillin resistant Staphylococcus aureus;microbicide;Mission;Molecular Weight;Morbidity - disease rate;mortality;neutrophil;pathogen;Pathogenesis;pathogenic bacteria;patient registry;Persons;Phagocytosis;Phagosomes;Production;Public Health;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;Reactive Oxygen Species;recruit;Research;respiratory pathogen;Respiratory System;Rest;Role;Sputum;Staphylococcus aureus;Staphylococcus aureus infection;targeted treatment;Testing;United States National Institutes of Health;weapons;Work

PROJECT_TITLE: The cystic fibrosis sputum compromises the ability of neutrophils to kill Staphylococcus aureus

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Patients diagnosed with glioblastoma (GBM) have a dismally poor prognosis (~7.5% relative five-year survival) despite intense standards of care including surgery, chemotherapy, and radiation therapy. The goal of this proposal is to investigate a novel photothermal nanoparticle-based approach for generating tumor-specific T cells as an adoptive T cell therapy (ATCT) for treating GBM. The long-term goal is to use this ATCT to improve treatment outcomes for GBM patients.

PI_NAMEs: CRUZ, CONRAD RUSSELL YOUNG;FERNANDES, ROHAN  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adjuvant;Adoptive Cell Transfers;Agonist;Animals;Antigen Presentation Pathway;antigen-specific T cells;Antigens;Automobile Driving;Biomanufacturing;Brain Neoplasms;C57BL/6 Mouse;Caring;Cell Separation;Cells;chemotherapy;chimeric antigen receptor T cells;Citrates;Cytolysis;cytotoxic;Dendritic Cells;design;Diagnosis;Dose;effective therapy;efficacy testing;engineered T cells;Engineering;Evolution;Formulation;Freezing;Glioblastoma;Glutathione;Goals;Heating;Heterogeneity;Immune;immunoengineering;immunogenic cell death;Immunologic Adjuvants;Implant;improved;In Vitro;in vivo;in vivo Model;Lasers;Lead;Liposomes;manufacture;Maps;Measures;Mediating;member;Memory;Methods;Modeling;Molecular;Mus;nanoformulation;nanoparticle;neoplastic cell;novel;novel therapeutics;Operative Surgical Procedures;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;Pattern;Pattern recognition receptor;Peripheral Blood Mononuclear Cell;personalized approach;Phase I Clinical Trials;Phenotype;photothermal therapy;Population;portability;preferentially expressed antigen in melanoma;Primary Brain Neoplasms;Process;Prognosis;Protocols documentation;Prussian blue;Publishing;Radiation therapy;Regimen;Resected;Residual Neoplasm;response;Safety;Sampling;Source;Specificity;standard of care;success;survival outcome;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;Techniques;Test Result;Testing;Treatment outcome;tumor;Tumor Antigens;Tumor Cell Line;Tumor Expansion;tumor heterogeneity;Tumor Immunity;tumor xenograft;Work;Xenograft Model

PROJECT_TITLE: Photothermal Nanoparticles Immune Engineer Tumor-specific T cells for Adoptive Cell Therapy

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative This research project aims to build virtual animals, specifically rats, that can behave and learn like real animals by giving them artificial 'brains' similar to those in real rats. We will teach these virtual animals to mimic rat behavior, then study how these 'brains' control this behavior to generate hypotheses about how biological brains perform similar functions. Any differences between how the virtual rats act and how real rats act will help the researchers improve their model, ultimately leading to a better understanding of how brains implement motor control.

PI_NAMEs: BRUNTON, BINGNI WEN;LINDERMAN, SCOTT WARREN;OLVECZKY, BENCE P (contact);PEREIRA, TALMO D.;RAJAN, KANAKA

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Acceleration;Anatomic Models;Animal Model;Animals;Architecture;Automobile Driving;Basal Ganglia;Behavior;Behavior Control;behavior influence;Behavioral;Biological;Biology;biomechanical model;Biomechanics;Brain;brain control;Brain region;Brain Stem;Cognition;Communities;Complex;Corpus striatum structure;Data;Data Analyses;deep neural network;design;Dopamine;Educational process of instructing;Environment;Evolution;Feedback;Future;Goals;Grant;Handedness;improved;in silico;in vivo;insight;Joints;Knowledge;Learning;Life;Link;Mediating;Modeling;Motor;motor control;Motor Cortex;motor learning;Movement;Muscle;Nervous System;neural;neural network;neuroethology;Neurosciences;Noise;novel;Output;Pattern;Performance;Physics;Physiological;Play;programs;Property;prototype;Rattus;Red nucleus structure;Research;Research Personnel;Research Project Grants;Robotics;Role;sensor;Sensory;Services;Signal Transduction;Skeleton;Source;Spinal Cord;statistics;Structure;Synapses;System;Testing;theories;Torque;Training;virtual;virtual animals;Work

PROJECT_TITLE: Understanding Sensorimotor Control Through Realistic Neuro-Biomechanical Simulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (12)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Prevention;Racial and Ethnic Minority Health Research;Uterine Cancer;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Infertility is a common public health problem that is more likely to burden Hispanic women and may increase a woman’s risk of chronic diseases (breast cancer, ovarian cancer, endometrial cancer, cardiometabolic diseases, and mortality). Within the Mexican Teacher´s Cohort, a prospective cohort of over 115,000 Hispanic women of Mexican heritage followed for 18 years, we will combine data on infertility history and specific infertility diagnoses and treatments to evaluate the relationship between infertility and the risk of chronic diseases and mortality.

PI_NAMEs: FARLAND, LESLIE V (contact);STERN, DALIA

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;Age;Biometry;Breast Cancer Risk Factor;burden of illness;cancer risk;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Characteristics;Chronic Disease;Clinical;cohort;Cohort Studies;Data;Data Sources;Development;Diabetes Mellitus;Diagnosis;Disease;disorder risk;Early Intervention;early screening;Electronic Health Record;Endometrial Carcinoma;endometriosis;Epidemiologic Methods;Epidemiology;Ethnic Population;experience;follow-up;Funding;Geography;Goals;Health;high risk;Hispanic;Hispanic Populations;Hispanic Women;Hypertension;improved;Incidence;Income;Infertility;Infertility study;infertility treatment;Knowledge;Life;Link;Literature;male;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Medical Records;Menopause;Menstrual cycle;Methodology;Mexican;Mexico;Minority Groups;Morbidity - disease rate;mortality;mortality risk;Myocardial Ischemia;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Outcome;parous;Participant;Patient Self-Report;Polycystic Ovary Syndrome;Population;Pregnancy Histories;Premature Mortality;Prospective cohort;Prospective, cohort study;Public Health;racial population;Recording of previous events;Registries;Reproductive Health;Reproductive History;Research;Research Personnel;Resources;Risk;Risk Factors;Sample Size;Severities;Severity of illness;Stroke;success;teacher;Time;trying to conceive;tubal infertility;United States;United States National Institutes of Health;Validation;White Women;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Infertility and Long-Term Health Outcomes Among Hispanic Women with Mexican Heritage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-J (55)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: No PHR

PI_NAMEs: ABRAMOV, DMITRY ;ANTON-CULVER, HODA A (contact);CHOW, EMILIE ;LEE, SCOTT ;LEVERONI-CALVI, MATTEO ;PARK, HANNAH LUI;REIKES, ANDREW ;STAMOS, MICHAEL J;YOUSSEF, FADY A;ZHENG, KAI ;ZIOGAS, ARGYRIOS

PROGRAM_OFFICER_NAME: PRABHUDAS, IRENE

PROJECT_TITLE: All of Us Southern California Consortium (AoUSCC): Engagement, Enrollment, and Retention of Diverse Populations


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Centrosomes are required for error-free mitosis and other cellular functions, and their deregulation drives developmental disorders, such as microcephaly and cancer. This proposal investigates novel paradigms of centrosome regulation by examining the functional consequences of mRNA localized to centrosomes.

PI_NAMEs: LERIT, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Active Biological Transport;Acute;Adhesions;autism spectrum disorder;Biochemistry;Biology;brain size;cancer biomarkers;cell behavior;Cell Cycle;Cell division;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Centrosome;Chromosomal Instability;cilium biogenesis;Complex;Congenital Abnormality;Coupled;Data;Developmental Delay Disorders;developmental disease;Disease;disease model;Drosophila genus;Dynein ATPase;Embryo;Engineering;fly;FMR1 gene;Foundations;Functional disorder;Future;Genetic;Genome Stability;Goals;Head;Health;Heritability;Homeostasis;Human;Image;Intellectual functioning disability;interdisciplinary approach;Interphase;Knowledge;Learning;Link;Malignant Neoplasms;Memory;Messenger RNA;Microcephaly;Microtubule-Organizing Center;Microtubules;migration;Minus End of the Microtubule;Mitosis;Mitotic spindle;Modeling;Monitor;Motor;Mutation;Neurodevelopmental Disorder;Normal Cell;novel;Paraneoplastic Cerebellar Degeneration;pericentrin;posttranscriptional;Prognostic Marker;Proliferating;Protein Biosynthesis;Proteins;recruit;Regulation;response;Ribonucleoproteins;RNA;RNA Sequences;RNA-Binding Proteins;Role;Site;spatiotemporal;Structure;Testing;trafficking;Translations;Work

PROJECT_TITLE: Post-transcriptional mechanisms of centrosome regulation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_DEPT: BIOLOGY

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative Neurovascular disorders – including stroke, brain aneurysm, and vascular malformations – strike an estimated seven million Americans annually, and can lead to vascular pathologies, neurological disability, and death. Our ongoing research has uncovered cellular and molecular mechanisms that contribute to a neurovascular disease called brain arteriovenous malformation, a neurovascular disease with no current treatments approved by the Food and Drug Administration. Based on our preliminary data, we propose to test a pharmacological based approach to alleviate features of brain arteriovenous malformation in mice and to prevent abnormalities in cultured human brain vascular cells.

PI_NAMEs: NIELSEN, CORINNE  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Abnormal Endothelial Cell;Address;adrenomedullin;Affect;American;Aneurysm;Arteries;Arteriovenous malformation;Attenuated;attenuation;Binding;Blood;Blood flow;Blood Vessels;Brain;Brain Aneurysms;brain arteriovenous malformations;brain endothelial cell;brain tissue;Cell Physiology;Cell Polarity;Cell Separation;Cells;Cellular Morphology;Central Nervous System;central nervous system vasculature;cerebral microvasculature;cerebrovascular;Cessation of life;ChIP-seq;Chromatin;Clinical Treatment;comparison control;Data;Data Set;Disease;effective therapy;Endothelial Cells;Endothelium;Event;FDA approved;Focal Adhesions;Genetic;Genetic Recombination;Goals;Health;high risk;Human;Hypertension;Immunoglobulin binding proteins;Impairment;In Vitro;in vivo;kappa-Chain Immunoglobulins;knock-down;Maintenance;malformation;Maps;Mediating;migration;Molecular;Molecular Target;mouse model;Mus;Mutant Strains Mice;Neurofibrillary Tangles;Neurologic;Neurologic Dysfunctions;Neurological disability;neurovascular;notch protein;novel;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathology;Patients;Peptides;pharmacologic;Pharmacological Treatment;Physiologic arteriovenous anastomosis;postnatal;prevent;Prevention strategy;Property;protein expression;Publishing;Quality of life;reduce symptoms;Research;Role;Sampling;Shunt Device;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Small Interfering RNA;small molecule inhibitor;Stroke;System;Testing;Therapeutic;therapeutic evaluation;Tissues;transcription factor;transcriptome sequencing;treatment strategy;United States Food and Drug Administration;vascular abnormality;Veins

PROJECT_TITLE: Inhibiting Adrenomedullin signaling to prevent mammalian brain endothelial cell abnormalities and brain arteriovenous malformation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: CORVALLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: A key barrier to widespread public translation and effective use of environmental and non- genomic health research findings is their inaccessibility to study participants and communities that enabled them. To address, this project aims to create ways to vastly improve availability and accessibility of research results to study participants, by enabling data sharing within and across studies, learning directly from participants to create a user-friendly, highly accessible forms of report-back of research results (RBRR). Using a process responsive to community and cultural norms, we will advance environmental health literacy, by discovering and thus leveraging people's motivations toward their decision-making toward reducing/preventing exposures to environmental contaminants.

PI_NAMEs: ROHLMAN, DIANA  (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;aged;Back;base;Behavior;behavior change;Benefits and Risks;Bioethics;Cellular Phone;Chemical Exposure;cohort;Communities;community advisory board;community engagement;Data;data sharing;data visualization;Decision Making;design;diverse data;Education;Environmental Hazards;Environmental Health;environmental justice;Environmental Pollutants;Ethics;Evaluation;Exposure to;extrinsic motivation;Focus Groups;Funding;Future;Geographic Locations;Guidelines;Health;Health behavior change;health equity;health literacy;Hispanic;improved;Individual;Information Distribution;inner city;intrinsic motivation;Knowledge;Knowledge Portal;Latinx;Learning;low socioeconomic status;Motivation;non-genomic;Not Hispanic or Latino;novel;Online Systems;open source;Outcome;Participant;patient engagement;Persons;pilot test;Population;Population Heterogeneity;preference;pregnant;Pregnant Women;prevent;Process;public health research;Publishing;Qualifying;Reporting;Research;Research Design;Research Personnel;response;Risk Reduction;Rural;Silicones;Socioeconomic Status;sound;Source Code;Spanish;study population;suburb;Surveys;Testing;tool;Translating;Translations;United States National Institutes of Health;usability;user-friendly;Visualization;wasting;web platform;web-based tool;wristband

PROJECT_TITLE: Translating Research to Action & Knowledge (TRAK) Portal: a web-based platform for report-back of research results

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Complementary and Integrative Health;Digestive Diseases;Immunotherapy;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Maternal immune cell transfer to the infant may assist in the education of the neonatal immune system. We recently demonstrated that orally feeding the probiotic Limosilactobacillus reuteri could educate circulating Tregs to become anti-inflammatory; and these T cells when adoptively transferred to newborn pups were more potent than naïve Tregs in facilitating immune tolerance. The proposed experiments will characterize probiotic- modulated immune cells migrating from mother to infant; and we will then assess the transfer of probiotic- modulated immunity from mother to infant in the setting of an established model of autoimmune disease.

PI_NAMEs: LIU, YUYING  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adaptive Immune System;Adoptive Transfer;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Bacteria;Breast Feeding;cell motility;Cell Physiology;Cells;Childhood;commensal bacteria;congenic;Dendritic Cells;Development;Differentiation Antigens;disease model;Education;Engineered Probiotics;Epithelium;experimental study;Exposure to;fecal microbiome;Feces;feeding;Fostering;FOXP3 gene;gut microbiota;Heterogeneity;Heterozygote;Human;Human Milk;Immune;immune function;Immune response;Immune system;Immune Tolerance;Immunity;Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome;Immunologic Factors;immunoregulation;improved;Infant;Infant Development;Infiltration;Inflammation;Inflammatory;Ingestion;intestinal barrier;Knowledge;Laboratories;Lactation;Leukocytes;Life;Lymphocyte;Lymphoid Cell;Macrophage;mammary;Mammary gland;Mediating;mesenteric lymph node;metabolomics;metagenome;Metagenomics;Microbe;microbial;microbial host;microbiota;microorganism;migration;Milk;Modeling;monocyte;Mothers;mouse model;Multiple Sclerosis;Mus;Myeloid Cells;Natural Killer Cells;Necrotizing Enterocolitis;Neonatal;neonatal immune system;neutrophil;Newborn Infant;Nutrient;Oral;Pathway interactions;Permeability;Placenta;Plasma;Population;Pregnancy;pregnant;Pregnant Women;Probability;Probiotics;pup;Regulatory T-Lymphocyte;Severity of illness;Shapes;single cell sequencing;stem;Surface Antigens;Symbiosis;Syndrome;T-Lymphocyte;Thy-1 Antigens;Thymus Gland

PROJECT_TITLE: Maternal-infant transfer of microbial modified immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: B. PROJECT NARRATIVE This shared instrument grant requests funding to acquire an inductively coupled plasma time-of-flight mass spectrometer (icpTOF-MS) for ultrafast multi-elemental mapping of high-value clinical (human) and preclinical (lab animal) biospecimens. The instrument will be coupled to the CBM’s existing state-of-the-art laser ablation platform at the Boston University School of Medicine Center for Biometallomics (CBM), the only hospital/medical school-based bioanalytical core facility of its kind in the region. The proposed icpTOF-MS instrument will facilitate NIH-funded research targeting Alzheimer’s disease (AD), other neurodegenerative diseases, traumatic brain injury, cardiovascular disease, chronic renal disease, degenerative eye disease (cataracts, retinopathy), heavy metal toxicology, and gene-environment (exposome) interactions.

PI_NAMEs: GOLDSTEIN, LEE E. (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Biomedical Research;Boston;Brain;Brain Concussion;Cardiovascular Diseases;Cataract;Cells;Chronic Kidney Failure;chronic traumatic encephalopathy;Clinical;Clinical Research;consumer product;Core Facility;Coupled;Data;Elements;Foundations;Framingham Heart Study;Funding;General Hospitals;Grant;Heavy Metals;Hospitals;Human;human tissue;Indiana;innovation;Institution;instrument;Laboratories;Lasers;Link;Liquid substance;Maps;mass spectrometer;mass spectrometric imaging;Medical Research;medical schools;meter;Microvascular Dysfunction;Minor;multiplex detection;Mus;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;Neurodegenerative Disorders;nonhuman primate;novel;Organ;Physiologic pulse;Plasma;pre-clinical;pre-clinical research;Preparation;Rattus;reconstruction;Research;Research Personnel;Resolution;Retinal Diseases;Sampling;Scanning;Series;Site;Specimen;Spottings;Stroke;System;tau Proteins;Techniques;Technology;The Jackson Laboratory;Time;Tissue Banks;Tissues;Toxicology;Traumatic Brain Injury;Universities;Vascular Dementia;Width

PROJECT_TITLE: ICP-TOF Mass Spectrometer for Ultrafast Elemental Mapping of Clinical and Preclinical Biospecimens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The P2Y10 receptor (P2Y10R) was initially identified as a member of the P2Y family of nucleotide receptors based on structural similarities. This project proposes to use bioinformatic and in vivo techniques to elucidate the role of P2Y10R in Sjögren’s disease (SjD) pathophysiology. Understanding the role of P2Y10R in SjD pathophysiology could establish a druggable target for SjD pharmacotherapy.

PI_NAMEs: JASMER, KIMBERLY J (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Ablation;Addison's disease;Address;Adenosine;Age;antagonist;Attention;Attenuated;Autoantibodies;Autoimmune Diseases;autoimmune thyroid disease;B-Cell Antigen Receptor;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Binding Proteins;Bioinformatics;Biological Assay;Biopsy;Bone Marrow;C57BL/6 Mouse;CD28 gene;CD4 Positive T Lymphocytes;Cell Communication;Cell Compartmentation;cell injury;Cell Maturation;cell motility;cell type;Cells;chemokine;Chronic;comparison control;Coupled;cytokine;Cytoplasm;Data;data modeling;Data Set;design;Development;differential expression;Disease;disease model;disease phenotype;disorder control;druggable target;Environmental Exposure;Enzymes;eye dryness;Family;Fatty Acids;Female;Functional disorder;Future;G-Protein-Coupled Receptors;Genetic;Gland;Graves' Disease;GTP-Binding Proteins;Homologous Gene;Human;Hyperactivity;Hypergammaglobulinemia;Immune;Immune response;immunoregulation;improved;in silico;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;interest;Interferon Type II;Interstitial Lung Diseases;Investigation;Laboratories;Lacrimal gland structure;Length;Ligands;LoxP-flanked allele;Lung;Lymphocyte;Lymphocytic Infiltrate;lymphoid organ;Lysophosphatidic Acid Receptors;lysophosphatidylserine;Lysophospholipids;Macrophage;Mediating;Mediator;member;men;Minor salivary gland structure;Modeling;Molecular;mouse model;Mus;Natural Killer Cells;new therapeutic target;novel;nucleotide receptor;Nucleotides;Ocular Pathology;Oral Pathology;overexpression;P2X-receptor;P2Y2 receptor;Parotid Gland;Pathogenesis;Patients;Pattern;Pattern recognition receptor;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phospholipase;Plasma Cells;Play;Population;Positioning Attribute;Process;Production;proto-oncogene protein Spi-1;Pulmonary Inflammation;receptor;Receptor Activation;receptor binding;receptor expression;Receptor Signaling;Resolution;response;Role;Salivary;Salivary Glands;Sampling;sexual dimorphism;Sialadenitis;Signal Transduction;single cell analysis;single-cell RNA sequencing;Sjogren's Syndrome;small molecule libraries;Specificity;Specimen;Spleen;Structure of germinal center of lymph node;Submandibular gland;symptom management;Systemic disease;T cell infiltration;T-Lymphocyte;Techniques;Testing;Time;Tissues;transcriptomics;tripolyphosphate;Up-Regulation;Virus Diseases;Woman;Xerostomia

PROJECT_TITLE: Illuminating the Role of the Novel G Protein-Coupled P2Y10 Receptor in Sjögren's Disease Pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (09)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  This project will establish and characterize a novel animal model used to investigate how alcohol affects brain function through the neuroimmune response (specifically through microglia, which are the resident immune cell of the brain). We aim to engraft genetically engineered human microglia derived from stem cells into the mouse brain, allowing us to selectively enrich the molecular signature of only human microglia from the mouse brain after the mice have been exposed to alcohol. Because we are studying the human microglial response in a living animal, we anticipate the results will have higher translational relevance in order to further our understanding of the negative consequences of alcohol use disorder in the human brain.

PI_NAMEs: STEVENS, STANLEY M (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Address;Affect;alcohol consequences;alcohol effect;alcohol exposure;alcohol misuse;alcohol response;alcohol use disorder;Alcohols;Amino Acids;analog;Animal Model;Animals;Automobile Driving;Body System;Brain;brain cell;brain tissue;Cell Line;cell type;Cells;Chemistry;Chimera organism;chronic alcohol ingestion;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CSF1R gene;Dose;Engineering;Engraftment;Environment;Enzymes;Ethanol;Exhibits;Flow Cytometry;Genetic Engineering;genetically modified cells;Harvest;Health;Human;human disease;Human Engineering;human induced pluripotent stem cells;human model;Immune;immunocytochemistry;Immunodeficient Mouse;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;inhibitor;Injections;innovation;insight;Label;Mass Spectrum Analysis;Mediating;Methionine;Methionine-tRNA Ligase;Microglia;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;Mutation;neonatal brain;neonatal mice;Neuroimmune;neuroinflammation;novel;novel strategies;Outcome;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Population;Process;Protein Biosynthesis;Proteome;Proteomics;response;Rodent;Specificity;stem cells;Testing

PROJECT_TITLE: Chimera-BONCAT: A novel in vivo model for in-depth characterization of the human microglial response to alcohol

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Signal regulatory protein α (SIRPα) is a polymorphic immunoglobulin receptor that is exclusively expressed on innate cells. We found that donor/recipient SIRPα mismatch is commonly detected in the setting of allo-HSCT and associated with a significantly increased risk of chronic graft-versus-host disease (cGVHD) and a reduced rate of disease relapse in various hematologic malignancies. The proposed research is to investigate the prevalence and clinical relevance of SIRPα mismatch in allo-HSCT from matched related donors (MRD), and the relative impact of SIRPα mismatch by disease type, alloimmune direction of the mismatch, and stem cell source in a registry-based large cohort from Center for International Blood and Marrow Transplant Research (CIBMTR).

PI_NAMEs: ZOU, JUN  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Graft Versus Host Disease;Adaptive Immune System;adaptive immunity;Affinity;Alloantigen;Allogenic;Allografting;AML/MDS;Binding;Blood;Bone Marrow Transplantation;CD47 gene;Cells;chronic graft versus host disease;Clinical;clinically relevant;clinically significant;cohort;Collaborations;curative treatments;Data;Disease;Disease-Free Survival;Donor Selection;effective therapy;Equilibrium;frontier;Genetic Variation;genomic locus;graft vs host disease;graft vs leukemia effect;Grant;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;HLA Antigens;Human;Immunity;Immunobiology;immunoglobulin receptor;Immunology;improved;Innate Immune Response;Innate Immune System;international center;isoimmunity;Knowledge;Ligands;Lymphocyte;Lymphoid Cell;Macrophage;Major Histocompatibility Complex;Malignant lymphoid neoplasm;Marrow;Methods;monocyte;mortality;mouse model;Mus;Natural Immunity;novel marker;Outcome;Patients;Phagocytes;Prevalence;prevent;programs;PTPNS1 gene;receptor;Recurrent disease;Registries;Relapse;relapse risk;Research;Research Project Grants;response;Retrospective Studies;Risk;risk stratification;Role;Sampling;secondary analysis;SHPS-1 protein;Signal Transduction;Source;Specimen;Stem cell transplant;stem cells;Subgroup;success;Surface;Survival Rate;Testing;Time;transplant centers;transplant model;Transplant Recipients;transplantation therapy;Variant

PROJECT_TITLE: Effect of SIRPalpha mismatch on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA matched related donor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J2)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: RIVERSIDE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Oral and intravenous drug administration lacks spatial targeting, exposing all organs and tissues to high drug concentrations, leading to severe off-target side effects. We have recently achieved proof-of-concept for a focal drug delivery technology using polymer-based intra-arterial implants. This proposal is designed to demonstrate the platform potential of our technology, by focally delivering two different drugs to two different organs.

PI_NAMEs: LIU, HUINAN HANNAH;ZAGHA, EDWARD W (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: absorption;Advanced Development;Affect;Animal Model;Arteries;Award;Behavior monitoring;biocompatible scaffold;biodegradable polymer;biomaterial compatibility;Biomedical Engineering;Blood flow;Blood Tests;Body Fluids;Brain;Carotid Arteries;Cisplatin;Clinical;clinical efficacy;commercialization;Data;design;Development;Dexamethasone;direct application;Disease;Disease Management;disease model;Drug Delivery Systems;Drug Exposure;Drug Kinetics;drug standard;Drug Storage;Drug Targeting;Effectiveness;Embolism;Excretory function;fabrication;Funding;Goals;Histologic;Implant;implant design;implantation;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Inflammation;Inflammatory Bowel Diseases;innovation;interest;Intervention;Intravenous;Kidney;Malignant Neoplasms;materials science;Measurement;Medical;Medicine;Metals;Methods;minimal risk;minimally invasive;Monitor;Oral;Organ;Pain;Partial Epilepsies;Perfusion;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Polymers;Postoperative Pain;pre-clinical;preclinical study;preclinical trial;Primary Neoplasm;Process;product development;prototype;Rattus;renal artery;Renal function;Research Personnel;Route;Safety;safety assessment;scaffold;side effect;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Steroids;success;Technology;technology development;technology platform;Testing;Therapeutic;Tissues;Toxic effect;Work

PROJECT_TITLE: Controlled focal drug delivery by endovascular bioresorbable composite implants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative This S10 application requests funding to obtain a unique Human Connectome 2.0 head-only scanner, which performance will be extraordinary: maximum gradient strength of 500 mT/m and maximum slew rate of 600 T/m/s. The order-of-magnitude boost of the diffusion weightings will enable fast and distortion-free brain MRI and dramatically advance microstructural brain mapping in a wide range of neurological disorders. The addition of the Connectome 2.0 will help us transform the field of microstructure imaging, benefiting brain researchers, patients and physicians who care for them, as well as other academic medical centers within the greater New York City area.

PI_NAMEs: FIEREMANS, ELS  (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Academic Medical Centers;advanced system;Aging;Area;Axon;biophysical model;Biophysics;Brain;Brain Mapping;Caring;Cell Density;Clinical;clinical practice;clinical translation;Computer software;connectome;Development;Diameter;Diffusion;Echo-Planar Imaging;Funding;Future;Glean;gray matter;Head;Human;Human Development;Image;Imaging technology;innovation;Institution;Investments;Joints;magnetic field;Magnetic Resonance Imaging;medical schools;meter;millimeter;Mission;Modeling;Myelin;Nervous System Disorder;New York City;Noise;novel;Patients;Performance;Permeability;Physicians;Property;Radiology Specialty;Request for Applications;Research;Research Personnel;research study;Resolution;S10 grant;Scanning;Signal Transduction;Site;Speed;Structure;System;theories;Thick;Time;Tissues;Translating;United States National Institutes of Health;Validation;white matter

PROJECT_TITLE: High Performance Gradient System for Advanced Microstructure MRI - Resubmission - 1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: Narrative Malaria patients frequently develop severe anemia, which can lead to death. We intend to study Xanthine Oxidase (XO), an oxidative enzyme that is upregulated during malaria and is associated with anemia in patients, to determine whether XO induces the loss of erythrocytes during malaria and whether medicines that inhibit XO could decrease malaria-induced anemia in mice models.

PI_NAMEs: RODRIGUEZ, ANA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;adverse outcome;Allopurinol;Anemia;Area;Bilirubin;Biological Assay;Biological Markers;Cause of Death;Cells;Cellular Stress;Cessation of life;Characteristics;Child;Childhood;Coculture Techniques;cohort;Communicable Diseases;Communities;Complication;defined contribution;Development;Enzymes;Erythrocytes;Exclusion;experimental study;Exposure to;febuxostat;Haptoglobins;Hemolysis;Hemolysis Induction;Hemolytic Anemia;Hospitalization;Human;Human Characteristics;In Vitro;Inbred BALB C Mice;Infection;Label;Macrophage;Malaria;malarial anemia;Measures;Medicine;Monitor;monocyte;mouse model;Mus;oxidative damage;Oxidative Stress;Parasitemia;Patients;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Physiological;Plasma;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Predisposition;Process;Rodent Model;Role;Sampling;Severity of illness;Sickle Cell Anemia;Symptoms;Time;Validation;Xanthine Oxidase;xanthine oxidase inhibitor

PROJECT_TITLE: Mechanisms of anemia in malaria

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Sepsis

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative: The overarching goal of this project is to develop safe continual learning methods for early sepsis detection that can adapt to new data while avoiding catastrophic forgetting and maintaining generalization. First, we will develop methods that update a small subset of weights in the existing model based on the new data, thereby preserving the previously learned knowledge while adapting to the new information and leading to a more robust and adaptive model for early sepsis detection. Second, we will develop methods to automatically detect distribution shift from streaming sepsis data, improve the out-of-distribution generalization capability of continual learning models, and quantify their prediction uncertainty.

PI_NAMEs: XIE, PENGTAO  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Adverse event;All of Us Research Program;Caring;Clinical;clinical practice;cohort;COVID-19;Data;Data Set;data warehouse;Decision Making;Detection;Diagnosis;diagnostic biomarker;diagnostic tool;Early Diagnosis;Early Intervention;Electronic Health Record;Ensure;Equilibrium;experimental study;forgetting;Functional disorder;Future;Goals;Health;health data;Immune response;improved;Infection;innovation;Intervention;Knowledge;Knowledge acquisition;Learning;learning strategy;Life;Machine Learning;machine learning model;Medical;Methods;Modeling;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;Nature;novel;novel diagnostics;Organ;patient population;Patient-Focused Outcomes;Patients;Performance;Periodicals;preservation;Process;Records;Risk;Risk Assessment;Safety;Sepsis;Stream;Symptoms;systemic inflammatory response;Testing;Time;Training;training data;Uncertainty;Update;Weight

PROJECT_TITLE: Safe Continual Learning for Sepsis Early Detection

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE This proposal will produce a collection of novel nanobodies to neurotoxic assemblies of mutant huntingtin exon1 and engineer chromobodies to identify similar conformers in live neurons and identify nanobodies, which block their formation. These studies will provide valuable knowledge on the pathogenic conformers of mutant huntingtin and produce novel diagnostic biosensors and potential therapeutics for target-specific intervention in HD.

PI_NAMEs: KHOSHNAN, ALI  (contact);LANGEN, RALF

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Animals;Antibodies;Antigen Targeting;Binding;Biological;Biological Assay;Biosensor;Brain;Brain Diseases;Cessation of life;Chimeric Proteins;Collection;Communities;conformer;Diagnostic;Diagnostic Imaging;diagnostic tool;Disease;Engineering;Epitopes;Event;Exons;experience;Hot Spot;Human;Huntington Disease;Huntington gene;Immunization;In Vitro;in vivo;inhibitor;insight;Intervention;Knowledge;Libraries;live cell imaging;Llama;Location;Mediating;Modality;Modeling;Molecular;molecular diagnostics;Monitor;mutant;nanobodies;nanoengineering;Nerve Degeneration;nerve stem cell;Neurobiology;Neurons;neurotoxic;neurotoxicity;novel;novel diagnostics;novel therapeutics;Nuclear;Organelles;Pathogenicity;Pathway interactions;Patients;Penetration;Physiological;Physiological Processes;prevent;Property;Proteins;Recombinant Proteins;Recombinants;Reporter;Reporting;Research;Shark;Specificity;Structure;Technology;Testing;Therapeutic;therapeutic target;Time;tool;Toxic effect;Visualization;Yeasts

PROJECT_TITLE: Developing novel nanobody-based biosensors and therapeutics for Huntington’s Disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Currently, there are no FDA-approved treatments for postoperative delirium, a condition that affects up to 80% of older adults in the Intensive Care Unit and is associated with prolonged hospital stays, elevated rates of nursing home placement, and high mortality. Perineuronal nets (PNN) – protective structures around neurons specialized in supporting cognitive functions that are impaired during delirium – hold promise in the search for new targets against delirium. By testing the role of PNN remodeling in the development of postoperative delirium, the proposed experiments aim to open up unprecedented opportunities to target PNN as a novel therapeutic approach against this devastating condition.

PI_NAMEs: LUNARDI, NADIA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: adverse outcome;Affect;Age;Alzheimer's disease patient;American;Anesthesia procedures;Area;Attention;Behavior;Blood - brain barrier anatomy;Brain;Breathing;Chondroitin Sulfate C;Chondroitin Sulfates;Clinical Treatment;Code;Cognition;Cognitive deficits;cognitive function;Conscious;Data;Death Rate;Decision Making;Delirium;Dementia;Development;Environment;Exhibits;experimental study;Exposure to;Extracellular Matrix;Failure;FDA approved;Hippocampus;Histology;Human;human old age (65+);Impaired cognition;Impairment;inattention;Individual;Inflammation;inhibitory neuron;Intensive Care Units;Interneurons;Intervention;Investigation;Isomerism;Length of Stay;Link;liquid chromatography mass spectrometry;Memory;Memory Loss;Microglia;Modeling;Morbidity - disease rate;mortality;Mus;Nerve Degeneration;Neurobiology;neuroinflammation;neuron regeneration;Neurons;novel strategies;novel therapeutic intervention;Nursing Homes;old mice;older adult;Operative Surgical Procedures;Parvalbumins;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Play;postoperative delirium;Predisposition;repaired;resilience;Risk;Role;Sedation procedure;stressor;Structure;Sulfate;synaptic function;Synaptic plasticity;Testing;Thinking;Translating

PROJECT_TITLE: Perineuronal nets: a new player in postoperative delirium?

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Autoimmune Disease;Psoriasis

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE B cells that produce the anti-inflammatory mediator IL-10 help clear inflammation of the skin and in other sites. Certain B cells produce the chemokine CXCL10, which attracts pro-inflammatory T cells. The goal of this proposal is to test whether IL-10+ B cells produce CXCL10 to lure pro-inflammatory T cells into their vicinity and to expose them to IL-10 thereby suppressing inflammation. The results of our studies will be relevant for understanding the regulation of immune responses during inflammation, infection, and cancer.

PI_NAMEs: DEBES, GUDRUN PHILOMENA (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Affect;Allergic Contact Dermatitis;Anti-Inflammatory Agents;Antigens;Applications Grants;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;chemokine;chemokine receptor;Chemotaxis;Clinical;Cutaneous;CXC chemokine receptor 3;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;Dinitrofluorobenzene;draining lymph node;effector T cell;experimental study;Exposure to;Flow Cytometry;Goals;Grant;Homeostasis;Homing;Hypersensitivity;Imiquimod;Immune response;immunoregulation;Immunosuppression;In Vitro;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Interleukin-10;Knowledge;Leucocytic infiltrate;Ligands;Lymphoid Tissue;Malignant Neoplasms;Measures;Memory;Modeling;mouse model;Mus;Pathology;Phase;Population;Property;Psoriasiform Dermatitis;Psoriasis;recruit;Regulatory T-Lymphocyte;Reporter;Resolution;restraint;Role;Site;Skin;skin disorder;Spleen;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing

PROJECT_TITLE: The role of CXCL10 expressing B cells in skin inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Women's Health Research

PHR: Project Narrative Relatively little is known about cross-gender friendships. In the proposed study, 60 pairs cross-gender friends will be observed in a context in which friends can offer support. Girls are expected to offer more support than boys, and support is expected to be related to positive perceptions of the friendships, so findings may be useful for promoting positive cross-gender interactions.

PI_NAMEs: ROSE, AMANDA J (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TITLE: Support in adolescents' cross-gender friendships: Understanding girls' disadvantage

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Penicillin allergic patients who receive 2nd line antibiotics for surgical site infection (SSI) prophylaxis are at higher risk of postoperative SSIs. We silenced low risk penicillin allergy alerts in our 14-hospital healthcare system. We propose to measure how much this changed SSI prophylaxis prescribing and SSI rates in our healthcare system.

PI_NAMEs: DURKIN, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Impact of removing low yield penicillin allergy alerts on surgical site infection rates

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  Many cancer treatments seek to induce the death of cancer cells via the programmed process termed apoptosis. This work will study a potentially detrimental aspect of this approach, by assessing the role of apoptotic cells in promoting the survival and metastasis of cancer cells at distant sites.

PI_NAMEs: HEADLEY, MARK BRYAN;OBERST, ANDREW ATWELL (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Apoptosis;Apoptotic;Attention;Binding;Blood Platelets;breast cancer metastasis;Breast Cancer Model;Breast Melanoma;cancer cell;cancer therapy;Cell Communication;Cell Death;Cell Reprogramming;Cell surface;Cell Survival;Cells;Cessation of life;Circulation;Coagulation Process;cohort;Complex;Coupled;Data;Data Set;Distant;Extravasation;Fibroblasts;Flow Cytometry;Goals;Growth;high dimensionality;imaging approach;Immune;Induction of Apoptosis;inhibitor;innovation;intravital microscopy;Lung;lung colonization;Macrophage;Malignant Breast Neoplasm;Mammary gland;Mammary Neoplasms;Maps;Mediating;Metastatic Melanoma;Modeling;Morbidity - disease rate;mortality;multidimensional data;Mus;Myelogenous;Myeloid Cells;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;Oncogenes;Outcome;Patients;Phosphatidylserines;Phospholipids;Platelet aggregation;Play;Postpartum Period;prevent;Primary Neoplasm;Process;prospective;Proteomics;Radiation;Reaction;Reagent;recruit;Role;side effect;single-cell RNA sequencing;Site;Stromal Cells;success;Surface;System;T-Lymphocyte;Testing;Therapeutic;Thromboplastin;Tissue Preservation;Tissues;transcriptomics;tumor;tumor growth;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Promotion of metastasis by apoptotic cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-4 (J1)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Diffuse midline gliomas (DMGs) are fatal brain tumors in children. Our studies indicate that targeting the metabolic enzyme glyoxalase 1 is lethal in combination with radiation for DMGs, and that deuterium metabolic imaging provides an early readout of response to therapy. Our proposal has the potential to enable precision metabolic therapy and imaging for DMG patients.

PI_NAMEs: VISWANATH, PAVITHRA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;adduct;Anatomy;Animals;Biological Markers;Brain;Brain Neoplasms;Brain Stem;brain tissue;cancer cell;Cells;Cessation of life;Child;Childhood;Childhood Brain Neoplasm;Clinic;clinical application;clinical care;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;Data;Deuterium;Diagnosis;diffuse midline glioma;disorder control;DNA;Drug Metabolic Detoxication;efficacy evaluation;Enzymes;Excision;Exploratory/Developmental Grant;Expression Profiling;Face;Funding;Glucose;glucose metabolism;Glutathione;glycation;Glycolysis;Glycolysis Induction;Goals;Growth;Histones;Human;Image;imaging biomarker;imaging modality;improved;in vivo;in vivo imaging;Induction of Apoptosis;inhibitor;innovation;Knowledge;Label;Lactoylglutathione Lyase;Left;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Childhood Neoplasm;Measures;Medicine;Metabolic;metabolic imaging;Metabolism;metabolomics;Methods;Modeling;Mus;neuro-oncology;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Oxidative Stress Induction;patient prognosis;Patients;Pediatric Neoplasm;Penetrance;precision medicine;premature;Production;Proliferating;Proteins;Pyruvaldehyde;Quality of life;Radiation;radiation response;Reactive Oxygen Species;Recurrent tumor;Reporting;response;Safety;Spinal Cord;stable isotope;standard of care;The Cancer Genome Atlas;Therapeutic;Time;Translating;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Visualization

PROJECT_TITLE: Synthetic combination therapy for diffuse midline gliomas

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: OXFORD

ORG_NAME: ELSOHLY LABORATORIES, INC.

ORG_STATE: MS

PHR: Narrative: Commercially marketed ∆8-THC products were found to have several contaminants (impurities) resulting from the chemical conversion of hemp-derived CBD to ∆8-THC. This project is directed towards the isolation and purification of those impurities in sufficient amounts to study their pharmacology and their interaction with ∆8-THC. In vitro and in vivo studies will be carried out on each impurity to delineate their individual effects as well as their effects on ∆8-THC activity.

PI_NAMEs: ASHPOLE, NICOLE M;ELSOHLY, MAHMOUD A (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acids;Address;Adverse event;Affinity;Agonist;Agriculture;antagonist;antinociception;Behavioral;Binding;Biological;Biological Assay;Body Temperature;cannabinoid receptor;Cannabinoids;Cannabis;Catalepsy;Chemicals;CNR1 gene;CNR2 gene;cohort;comparative efficacy;Consumption;Cyclic AMP;Cyclization;Dose;efficacy evaluation;Evaluation;Female;Goals;GPR55 receptor;Hemp;Human;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Individual;insight;Isomerism;Left;Locomotion;male;manufacture;Manufacturer;Marketing;Measures;Minor;Morphologic artifacts;Motor Activity;Mus;natural hypothermia;Neurons;Nociception;novel;Pharmacodynamics;pharmacologic;Pharmacology;Plants;Policies;Procedures;Process;Production;Property;Protocols documentation;Public Health;Publishing;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;research clinical testing;response;Risk;Rodent;Safety;Sampling;scale up;Signal Transduction;synergism;Testing;Tetrahydrocannabinol;Work

PROJECT_TITLE: Isolation and Pharmacological Evaluation of Impurities in Δ-8-THC Products

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


PHR: PROJECT NARRATIVE Blood vessels in the central nervous system (CNS) have specialized properties, termed the blood-brain barrier (BBB), that facilitate proper CNS function. The BBB is an obstacle to CNS drug delivery and BBB dysfunction contributes to several neurological disorders. In this project, we investigate the cells and molecules that establish the BBB in diverse vertebrate species, which will provide fundamental insights into how the BBB evolved and may yield new strategies to modulate the BBB to treat disease.

PI_NAMEs: DANEMAN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: African;Alzheimer's Disease;Astrocytes;Biological Assay;Black Panther;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;Brain;Brain Injuries;brain parenchyma;brain tissue;Cardiovascular system;cell type;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Characteristics;Chimera organism;Choroid Plexus Epithelium;Complex;Data;Disease;Drug Delivery Systems;Elasmobranchii;Electron Microscopy;Electrons;Endothelial Cells;Endothelium;Energy Supply;Environment;Epilepsy;Evolution;extracellular;Extravasation;Fishes;Foundations;genome annotation;Hagfish;Horseradish Peroxidase;human data;improved;In Situ Hybridization;Injections;insight;Invertebrates;Ion Transport;Ions;Knowledge;Lampreys;Leukocyte Adhesion Molecules;Life;Liver;lungfish;member;model organism;Modernization;Molecular;Molecular Analysis;Molecular Profiling;Molecular Target;molecular transporter;Movement;Multiple Sclerosis;Mus;Nervous System;Nervous System Disorder;Nervous System Physiology;Neuroglia;Neurons;neurotransmission;novel;Octopus;Oncorhynchus mykiss;Organism;Pathogenesis;Pathway interactions;Phylogenetic Analysis;Phylogeny;Positioning Attribute;prevent;Process;Property;reference genome;repaired;Salmo trutta;Series;Shark;single nucleus RNA-sequencing;stingray;Stroke;Techniques;teleost;Tetrapoda;Tight Junctions;Tissues;Tracer;trafficking;Transcript;transcriptome;transcriptome sequencing;Vascular Endothelial Cell;Vertebrates;Vesicle;virtual;Visualization;Work;Zebrafish

PROJECT_TITLE: Cross species molecular analysis of glial and endothelial blood-brain barriers

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In this application we propose to study the mechanisms by which the type 1 diabetes PTPN2 risk-allele contributes to loss of B cell tolerance during the pathogenesis of disease using a mouse model for diabetes. The overarching goal of these studies is to better understand how genetic factors contribute to type 1 diabetes by changing the activity of autoreactive B cells in hopes of translating findings into novel therapeutic targets to treat the disease.

PI_NAMEs: SMITH, MIA  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Acceleration;Affect;Affinity;Age;Alleles;anergy;Antibodies;Antigen Presentation;Antigen Receptors;Antigen-Presenting Cells;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B-Lymphocytes;Beta Cell;Blood;C57BL/6 Mouse;Cell Compartmentation;Cells;Clonal Deletion;comorbidity;comparison control;Complex;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;DNA;Environmental Risk Factor;Exhibits;First Degree Relative;follow-up;Frequencies;Future;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genome wide association study;Goals;high risk;HLA Antigens;Human;Hyperglycemia;Immune Tolerance;Immunoglobulin G;Impairment;Inbred NOD Mice;Incidence;Individual;Inguinal lymph node group;Insulin;Insulin Antibodies;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Knock-out;Knowledge;lymph nodes;Lymphocyte;Maintenance;Mentored Research Scientist Development Award;mouse model;Mus;new therapeutic target;Non obese;novel therapeutics;Pancreas;Pathogenesis;Pathogenicity;Patients;Penetrance;Phenotype;Prediabetes syndrome;prevent;Production;Protein Tyrosine Phosphatase;receptor;Resistance;response;Risk;risk variant;Role;Signal Transduction;Single Nucleotide Polymorphism;Spleen;Structure of beta Cell of islet;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Translating

PROJECT_TITLE: Role of Ptpn2 in B cells during development of autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Microbiome;Neurosciences

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Several lines of evidence suggest that a gut-microbiota-brain axis connection is involved in the pathophysiology of ME/CFS. Mice that received fecal transplants from human donors with other neuroimmune diseases present with behavioral alterations consistent with these diseases, suggesting that fecal transplants may be used to create humanized mouse models of ME/CFS. Therefore, we propose to develop humanized mouse models of ME/CFS by using stool from ME/CFS subjects and healthy controls. Fecal transplants will be made using C57BL/6J mice and Hu-CD34+ NSG-SGM3 transgenic mice engrafted with a human immune system. We will then evaluate these mice for behavioral alterations and mucosal and neuroimmune alterations consistent with ME/CFS.

PI_NAMEs: LOMBARDI, VINCENT C (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Address;Affect;Age;American;Animal Model;Assessment tool;autism spectrum disorder;autistic;Behavior;Behavioral;Biological Assay;Blood - brain barrier anatomy;Brain;brain fog;Breathing;CD34 gene;Chest;Chronic;Chronic Fatigue Syndrome;Cities;Clinical;comorbidity;Data;Defect;Development;Diagnosis;Disease;Dizziness;dysbiosis;Economic Burden;efficacious treatment;Engraftment;Ensure;epidemiology study;Exclusion;exercise intolerance;Exertion;Fatigue;fecal transplantation;Feces;Fluorescent Dyes;Foundations;Functional disorder;gastrointestinal;Gender;Genetic Transcription;Genus Hippocampus;Geography;Goals;gut homeostasis;gut microbiome;Headache;Health;Hematopoietic;Hematopoietic stem cells;High Pressure Liquid Chromatography;Homeostasis;Human;human biological material;human subject;humanized mouse;Illness impact;Immune;Immune response;Immune system;Immunodeficient Mouse;intestinal barrier;Irritable Bowel Syndrome;Knowledge;Laboratory mice;Leaky Gut;Malaise;Mass Spectrum Analysis;Measures;Memory impairment;Mental Depression;metabolomics;Methods;microbiota;microbiota-gut-brain axis;Mitochondria;Modeling;mouse model;Movement;Mucosal Immunity;Mucous Membrane;Mus;neglect;Neurocognitive;Neuroimmune;neuroimmunologic disease;Neurologic;Oxygen Consumption;Pathologic;Pathology;Patients;Periodicity;Persons;population based;Prevention;Public Health;Publishing;Research;research study;Rodent;Role;Schizophrenia;Short-Term Memory;Sleep;Sleep disturbances;Sodium Chloride;stem cell engraftment;stool sample;Symptoms;System;Tissues;transcriptome sequencing;Transgenic Mice;Transplantation;treadmill;United States;Utah

PROJECT_TITLE: Development of humanized microbiota mouse models of ME/CFS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CFS-J (80)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: NEUROLOGY

PHR: Relevance Autism spectrum disorder is a neurodevelopmental disorder that affects approximately 1% of the population, and is defined by social communication impairments, repetitive behaviors, and alterations in sensory and sensorimotor processing. This work will reveal how dysfunction in the autism-linked gene SCN2A disrupts sensory and sensorimotor processing in the brain, and will test whether novel therapeutic methods that restore SCN2A expression to normal levels can rescue cellular, network, and behavioral alterations in a mouse model of Scn2a disruption. This may enable development of novel therapies for severe genetic forms of autism.

PI_NAMEs: BENDER, KEVIN J (contact);FELDMAN, DANIEL

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Action Potentials;Acute;Adolescence;Adolescent;Adult;Affect;Alleles;Animals;Area;autism spectrum disorder;Axon;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Biological Markers;Brain;Brain region;Cell Physiology;Cells;Cerebellum;Code;CRISPR-mediated transcriptional activation;critical developmental period;critical period;Cytoplasmic Granules;Data;Dendrites;Development;Disease;effective intervention;effectiveness evaluation;effectiveness testing;efficacy evaluation;Electrocorticogram;Electroencephalography;Enhancers;Exhibits;experimental study;Frequencies;Functional disorder;functional genomics;Gene Expression;gene therapy;Genes;Genetic;Goals;granule cell;High-Throughput Nucleotide Sequencing;Human;Impairment;induced pluripotent stem cell;Intervention;Laboratories;Learning;Link;loss of function;loss of function mutation;Loss of Heterozygosity;Maps;Membrane;Methods;model of autism spectrum disorder;Modeling;Morbid Obesity;Motor;mouse model;Mus;Neocortex;neocortical;neural;Neurodevelopmental Disorder;Neurons;novel therapeutics;Phenotype;Physiological;Physiology;Population;Positioning Attribute;postsynaptic;Prefrontal Cortex;Preparation;promoter;Proteins;Purkinje Cells;Pyramidal Cells;Reagent;Reflex action;repetitive behavior;response;risk variant;SCN2A protein;Sensory;sensory cortex;social communication impairment;Sodium Channel;somatosensory;Somatosensory Cortex;Space Perception;Specificity;Synapses;synaptic function;Synaptic plasticity;System;Testing;Therapeutic;Therapeutic Intervention;Touch sensation;Transcription Coactivator;transmission process;Up-Regulation;vestibulo-ocular reflex;Vibrissae;Visual;voltage;Work

PROJECT_TITLE: CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Congenital heart disease (CHD) affects about 40,000 births per year (1%) in the United States and these children frequently need surgery to repair the problem. This project aims to develop, validate, and clinically evaluate a patient-specific heart simulator that will allow surgeons to compare repair techniques for children with single-ventricle physiology. This simulator will enable doctors to make more informed decisions about the best surgical approach for each kid in order to improve their heart health.

PI_NAMEs: ENNIS, DANIEL B;MA, MICHAEL ;MARSDEN, ALISON L (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Age;Anatomic Models;Anatomy;Antibodies;Biomechanics;Birth;Blood flow;Blood Vessels;Cardiac;Cardiac health;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular Models;Child;Childhood;Circulation;Clinical;Clinical Research;cohort;Common Ventricle;Complex;Computer Models;congenital heart abnormality;Coupled;Custom;Data;Death Rate;design;Development;Diffusion;Disease;Electrophysiology (science);Elements;Fiber;Fontan Procedure;Future;Goals;Heart;Heart Diseases;heart disorder diagnosis;Heart failure;Heart Transplantation;Heart Valves;hemodynamics;high risk;Image;image processing;improved;improved outcome;individual patient;Infant Mortality;Label;Laws;Liquid substance;Machine Learning;machine learning method;Magnetic Resonance Imaging;mechanical properties;Mechanics;Methods;Modeling;Morbidity - disease rate;mortality;Myocardial;novel;Operating Rooms;Operative Surgical Procedures;Outcome;palliate;patient population;patient subsets;Patients;Pediatric Surgical Procedures;Physics;Physiology;Population;Positioning Attribute;Postoperative Period;Procedures;Property;prospective;public database;Pump;reconstruction;Reconstructive Surgical Procedures;repaired;Risk;Septate;Shapes;simulation;Single ventricle congenital heart disease;Solid;standard of care;Structure;Surgeon;System;Techniques;Technology;Testing;Tissues;tool;Translating;Transplantation;treatment planning;United States;Validation;Venous Pressure level;Ventricular

PROJECT_TITLE: A multi-physics simulator for pediatric cardiac surgical planning

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Narrative This proposal is to develop screening technologies to enable scientists to identify new interactions between cell surface proteins. Antibody drugs, which comprise a large fraction of the drugs developed in recent years, are directed against cell surface proteins and their ligands, so the ability to find interactions in an efficient manner may lead to the identification of new therapeutic targets.

PI_NAMEs: HOFFMANN, MAGNUS ADRIAN GERO;ZINN, KAI G (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Antibodies;Bar Codes;Binding;Binding Proteins;candidate identification;career;Cell Communication;Cell membrane;Cell Separation;Cell surface;Cell Surface Proteins;Cells;cellular transduction;Chimeric Proteins;Collaborations;Communities;Cytoplasm;density;Development;Drosophila genus;Encapsulated;Engineering;Enterobacteria phage P1 Cre recombinase;experimental study;extracellular;Extracellular Domain;extracellular vesicles;G-Protein-Coupled Receptors;Genes;Goals;Human;Human Genome;In Vitro;interest;Libraries;Ligands;Maintenance;Mammals;Maps;Mediating;Medicine;member;Membrane;Membrane Fusion;Methods;Molecular Conformation;mutant;Nervous System;Nervous System control;nervous system development;neural circuit;Neurons;new technology;new therapeutic target;Organ;Orphan;Outcome;Pharmaceutical Preparations;Physiology;Proteins;Publishing;receptor;Research;Research Personnel;RNA;Scientist;screening;single-cell RNA sequencing;Sorting;Surface;Technology;Tissues;Transmembrane Domain;vesicular stomatitis virus G protein

PROJECT_TITLE: A Cell-Based Screen for Global Mapping of Interactions among Neural Cell Surface Proteins

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_DEPT: DENTISTRY

PHR: Project Narrative We propose to test the hypothesis that the high incidence of pain in the elderly is due to hyperalgesic priming, caused by cellular senescence and systemic inflammation. Elucidating the Type of priming, the nociceptor population in which it occurs, the role of mitochondrial dysfunction, and the sex differences in priming could provide valuable information about pain mechanisms in the elderly, leading to a more effective and personalized management of their chronic pain.

PI_NAMEs: ARALDI, DIONEIA  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Affect;Afferent Neurons;Age;age related;age related changes;Age related pathologies;age-related disease;aged;Aging;aging population;allostatic load;Applications Grants;Blood specimen;Cell Aging;chemotherapy;Chronic;chronic pain;chronic pain management;Clinical;Collaborations;Complex;Coupling;cytochrome c;cytokine;Cytosol;Development;Dinoprostone;Disease;Economics;Elderly;Electron Transport;Electrons;Equilibrium;Exhibits;experience;experimental study;Frequencies;Genus Hippocampus;Heritability;Hour;Human;human old age (65+);Human Resources;Hybrids;Hyperalgesia;Immunofluorescence Immunologic;in vivo;Incidence;Inflammasome;Inflammation;Inflammatory;inhibitor;interest;Interleukin-6;life span;Link;Longevity;Measures;Medical;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morbidity - disease rate;mortality;Mus;Nervous System Disorder;Neuronal Plasticity;Neurons;Nociceptors;Norway;novel;novel therapeutics;older adult;Operative Surgical Procedures;Oxidation-Reduction;Oxidative Stress;Oxygen Consumption;Pain;Pain intensity;Pain management;pain perception;pain signal;Pathway interactions;Patients;Pattern;personalized management;Persons;Physical activity;Population;Prevention;Probability;Production;Quality of life;Rat Strains;Rattus;Reactive Oxygen Species;Reporting;Research;Respiration;respiratory;Role;sex;Sex Differences;sexual dimorphism;social;social implication;socioeconomics;Spinal Ganglia;Stress;Stressful Event;Succinates;Suggestion;Superoxides;Syndrome;systemic inflammatory response;Testing;TNF gene;Trauma;United Nations;Woman;Women's prevalence;young adult

PROJECT_TITLE: Pain in the Elderly: Role of Hyperalgesic Priming

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Fragile X Syndrome;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: SACRAMENTO

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

PHR: PROJECT NARRATIVE Air pollution is an emergent environmental risk factor for neurodevelopmental disorders (NDDs), but neurotoxicity profiles of different types of air pollution and gene by environment impacts are lacking. This study will establish Drosophila melanogaster as a model for the analysis of air pollution neurotoxicity by conducting behavioral analyses and metabolomic profiling following developmental exposure to diesel exhaust. Because phenotypic outcomes will be delineated in both wild-type flies and a fragile X syndrome model of Drosophila, this research holds the potential to create a rapid in vivo system both for air pollution neurotoxicity risk assessment and for studying gene-environment interactions relevant to NDDs.

PI_NAMEs: MILLER-SCHULZE, JUSTIN P. (contact);MULLIGAN, KIMBERLY ANNE

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Affect;Air Pollutants;Air Pollution;autism spectrum disorder;Behavior;Behavioral;behavioral outcome;Behavioral Paradigm;behavioral phenotyping;Biological Markers;Brain;Chemicals;Child;Complex;cost;Courtship;Defect;Development;developmental neurotoxicity;dFMR1 gene;Diesel Exhaust;Disease;Dose;Drosophila genus;Drosophila melanogaster;Embryo;Environment;Environmental Risk Factor;epidemiology study;Etiology;Exhibits;experimental study;Exposure to;fly;FMR1 gene;Fragile X Syndrome;Gases;gene environment interaction;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic strain;Grooming;Human;Hydrocarbons;Hyperactivity;Impairment;in vivo;in vivo Model;Inhalation;Inherited;Insecta;Instinct;Intellectual functioning disability;Laboratory Study;Larva;Measures;Metabolic;metabolomics;Metals;Modality;Modeling;Motor Activity;mutant;neurodevelopment;Neurodevelopmental Disorder;Neurologic;neuromuscular;neurotoxicity;novel;null mutation;Organism;Orthologous Gene;Outcome;Particulate;Particulate Matter;Phase;Phenotype;Physiological;Pollution;Prevalence;Protocols documentation;rapid testing;repetitive behavior;Research;response;Risk;Risk Assessment;Risk Factors;risk variant;Role;Source;Students;Synapses;synaptogenesis;System;Testing;Toxic effect;training opportunity;undergraduate research;United States

PROJECT_TITLE: Establishing Drosophila melanogaster as a model for developmental neurotoxicity assessment of air pollutants using diesel exhaust

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE The goal of this S10 shared-instrumentation grant is to obtain a BD FACSymphony S6 cell sorter to be placed in the Flow Cytometry Core of the California National Primate Research Center, where it will be dedicated primarily to use in translational, preclinical studies with nonhuman primates. This instrument will significantly benefit studies spanning research domains including immunology, infectious disease, gene therapy and somatic cell genome editing, regenerative medicine and stem cell transplantation, cardiovascular disease, cancer, and neurodevelopment—all to be addressed across the lifespan from pediatrics to geriatrics. The BD FACSymphony S6 will allow investigators to make observations at the single-cell level using samples from nonhuman primates, leading to new mechanistic understanding and eventually improved medical care.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J. (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 20 year old;adeno-associated viral vector;Advisory Committees;Age;California;Cardiovascular Diseases;cell type;Cells;Clinical Research;Clinical Trials;Communicable Diseases;Contract Services;Contracts;Core Facility;COVID-19 vaccine;Flow Cytometry;Funding;Future;gene therapy;genome editing;HIV vaccine;Human;Immunologics;Immunology;Individual;Infrastructure;innovation;insight;Institution;instrument;Laboratories;Lasers;Maintenance;Malignant Neoplasms;Minor;Modernization;neurodevelopment;next generation;novel;operation;Pathogenesis;Phase;Primates;Regenerative Medicine;Reproducibility;Request for Proposals;Research;Research Personnel;Research Project Grants;Retinal gene therapy;Sampling;SIV;somatic cell gene editing;Stem cell transplant;Stress;Therapeutic Studies;Tissues;Translational Research;United States National Institutes of Health;vaccine candidate

PROJECT_TITLE: BD FACSymphony S6

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


ORG_CITY: BRONX

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project will test the effectiveness of TOGA-DKD, a pharmacist-led transition of care intervention, to improve guideline adherence in patients with diabetic kidney disease identified during a hospitalization. Study pharmacists will meet with patients and their hospital teams before discharge to ensure prescribing of guideline medication and will follow up post-discharge to ensure adherence to the new medication. The knowledge about feasibility gained will demonstrate hospitalization as a viable population health implementation opportunity that can be used to mitigate health disparities in guideline adherence.

PI_NAMEs: DI PALO, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Transitions of care program to make guideline-based recommendations actionable for patients with diabetic kidney disease (TOGA-DKD)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Project Narrative Despite WTCHR Survivor’s high rates of 9-11-related and subsequent losses, minimal research has focused on the examination of grief responses (including the presence of PGD) and their effects on mental (including cognitive difficulties), social, environmental, and physical health-related quality of life (HRQoL) in this population while accounting for the effects of gender, race, and ethnicity. Using existing WTCHR data regarding 9/11 trauma burden and newly-collected information (regarding other traumas, bereavement burden, physical and mental health burden, grief severity, HRQoL, and cognitive difficulties), we will examine the complex inter-relationships among these variables to outline risk pathways in order to better inform WTCHP programming. We also intend to examine whether WTCHR Survivors at-risk for PGD have access to or would engage in grief-specific treatments, given that treatments for PTSD, depression, and anxiety disorders have not been engaged by all WTCHR participants.

PI_NAMEs: COZZA, STEPHEN  (contact)

PROJECT_TITLE: Grief and health-related quality of life in WTCHR Survivors: Associations with bereavement, trauma exposures, and mental and physical health conditions


ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The North Carolina Occupational Safety and Health Education and Research Center’s (NC OSHERC) education and research program is designed to prepare practitioners and researchers in occupational health and safety (OHS), with a specific focus given to training diverse, underrepresented, and minority practitioners and researchers. In turn, these professionals protect and promote the health and safety of our nation’s workforce. Education and research in OHS are essential to eliminate work-related hazards, improve workplace safety, and promote worker well-being of all workers.

PI_NAMEs: NYLANDER-FRENCH, LEENA A (contact)

PROJECT_TITLE: North Carolina Occupational Safety and Health Education and Research Centers


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: MEYER, JOHN D (contact)

PROJECT_TITLE: OCCUPATIONAL SAFETY AND HEALTH EDUCATION AND RESEARCH CENTERS (T42)


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses a major knowledge gap in our understanding of recurrent pregnancy loss by investigating male factor causes. This study will identify abnormalities in the quality of sperm and establish a new clinical paradigm to include diagnostic sperm testing of men with recurrent pregnancy loss. Thus, the proposed research is highly relevant to the NICHD's mission to elucidate the molecular mechanisms of early pregnancy loss.

PI_NAMEs: MAK, WINIFRED W (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Aberrant DNA Methylation;Address;adverse pregnancy outcome;Affect;Aging;Aniline;animal data;Animals;Area;Biological Assay;Candidate Disease Gene;Chromosomal translocation;Classification;Clinical;clinical diagnostics;cohort;Couples;Data;Data Set;Defect;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;DNA;DNA Damage;DNA Fragmentation;DNA Methylation;early pregnancy loss;Embryonic Development;Ensure;epidemiology study;Epigenetic Process;epigenome;Exclusion;experience;experimental study;Female;Genes;Genetic;genetic analysis;Genome;genome integrity;genome-wide;genome-wide analysis;Genomic Imprinting;Genomic Instability;genomic locus;Habitual Abortion;healthy pregnancy;Histones;Human;imprint;improved;Infertility;innovation;insight;Karyotype;Knowledge;male;Measures;men;methylome;Micrococcal Nuclease;Mission;Molecular;Molecular Analysis;Mosaicism;Multiomic Data;Mutation;National Institute of Child Health and Human Development;Nested Case-Control Study;novel;Nucleotides;Pattern;Phenotype;Play;predictive modeling;Pregnancy;Pregnancy Complications;Pregnancy loss;Premature aging syndrome;Public Health;Recurrence;Reproductive Medicine;Research;Research Priority;Risk;Role;Seminal fluid;sperm analysis;sperm cell;sperm quality;Spontaneous abortion;Stains;Technology;Testing;Therapeutic;treatment strategy;trying to conceive;unethical;United States;Work

PROJECT_TITLE: The genome integrity and epigenome of sperm from men with recurrent pregnancy loss


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: HOUSTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE African American oropharyngeal cancer patients present with more advanced disease and fail conventional treatment at a higher rate compared to their white counterparts. In the current proposal we aim to determine whether oropharyngeal cancer biology, progression and treatment response is impacted by race/ancestry in order to develop precision oncology approaches for this deadly disease in African American patients.

PI_NAMEs: CORREDOR, GERMAN ;SANDULACHE, VLAD C (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Address;advanced disease;African American;behavioral response;Biological;Cancer Biology;cancer care;cancer diagnosis;Cancer Patient;cancer survival;cancer therapy;care delivery;Characteristics;Classification;Clinical;Clinical Data;clinical translation;cohort;conventional therapy;County Hospitals;Data;Data Set;design;Development;differential expression;Disease;Disparity;disparity reduction;effective therapy;Environmental Exposure;Equity;Exhibits;Frequencies;Gene Expression Profile;Genes;Genomics;Head and Neck Cancer;Health Services Accessibility;high throughput analysis;histological slides;HPV negative;HPV positive;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune checkpoint inhibitor;improved;Inferior;Institution;Integration Host Factors;Link;Machine Learning;Malignant neoplasm of cervix uteri;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Medical center;Metastatic/Recurrent;Molecular Analysis;neoplastic cell;non-smoker;novel;Outcome;patient population;Patient Self-Report;Patients;Physicians;Population;Pre-Clinical Model;precision oncology;Progression-Free Survivals;Publishing;Race;racial disparity;Regional Cancer;Reproducibility;response;Risk;Single Nucleotide Polymorphism;Smoker;Smoking;Smoking History;Societies;socioeconomics;Spatial Distribution;Specimen;standard of care;T-cell inflamed;Testing;Time;Tissue-Specific Gene Expression;Tobacco;transcriptomics;treatment response;tumor;Tumor Biology;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;United States;United States Department of Veterans Affairs;Validation

PROJECT_TITLE: Determining the impact of ancestry on oropharyngeal cancer biology and treatment response.

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE We propose a six week long undergraduate summer institute in Biostatistics and Data Science: “Transforming Analytical Learning in the Era of Big Data” to be held each summer (2022-2026) at the Department of Biostatistics, University of Michigan (U-M), Ann Arbor, with a group of approximately 30 undergraduate students. The trainees will be taught and mentored by a team of interdisciplinary faculty from Biostatistics, Statistics, Computer Science and Engineering, Epidemiology and Medicine, reflecting the shared intellectual landscape needed for biomedical Big Data research. Research projects will be identified in collaboration with clinicians and public health scientists with a focus on cardiovascular and infectious diseases. The program will offer a strong professional development component and a module on the role of data science in enhancing diversity, equity and inclusion values in society. The resources developed for the summer institute, including lectures, assignments, projects, template codes and datasets will be freely available through a Wiki page and a YouTube channel. This democratic dissemination plan will lead to access of teaching and training material in this new field across the world and allow others to replicate and adapt this program. The overarching goal of our summer institute in big data is to recruit and train the next generation of data scientists using a non- traditional, action-basedlearning paradigm and engage them in influential research related to human health.

PI_NAMEs: KANG, JIAN ;MUKHERJEE, BHRAMAR  (contact);ZAWISTOWSKI, MATTHEW STEPHEN

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Active Learning;Adverse drug effect;Area;Arts;Award;Awareness;Bachelor's Degree;Behavioral Sciences;big biomedical data;Big Data;Big Data to Knowledge;big-data science;Biological Markers;Biology;Biometry;burden of illness;Cardiovascular Diseases;career;Case Study;Clinical;cluster computing;Code;cohort;Collaborations;Collection;college;Communicable Diseases;Communities;computer science;Computing Methodologies;current pandemic;Data;data integration;data management;data mining;Data Science;Data Scientist;Data Set;Data Sources;data visualization;design;Development;Discipline;Disease;Diverse Workforce;Education;Educational process of instructing;Educational workshop;Electronic Health Record;Engineering;Enrollment;Epidemiology;Epigenetic Process;Equity;equity, diversity, and inclusion;Ethics;experience;Exposure to;Faculty;Female;Focus Groups;Future;Generations;Genetic;Genomics;Goals;Graduate Education;graduate school;Grant;Health;health data;Health Sciences;heterogenous data;high dimensionality;Human;Image;improved;Infectious Disease Epidemiology;infectious disease model;Influentials;Institution;instructor;interest;Knowledge;Learning;lectures;Literature;mathematical model;Medical;Medicine;member;Mentors;metabolomics;Methodology;Michigan;Minority Groups;National Heart, Lung, and Blood Institute;Natural Language Processing;network models;Neurosciences;next generation;novel therapeutics;open source tool;Oral;pandemic disease;Participant;personalized medicine;Persons;population health;posters;Prevention;Problem Sets;programs;Public Health;Public Health Informatics;Public Health Schools;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resources;Role;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Seminal;Series;Shapes;skills;social;Social Behavior;Social Justice;Societies;statistical and machine learning;Statistical Methods;statistics;STEM program;Student Selections;Students;success;summer institute;symposium;Talents;Techniques;tool;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Vaccines;Vision;wiki;Woman;Work

PROJECT_TITLE: Transforming Analytical Learning in the Era of Big Data: A Summer Institute in Biostatistics and Data Science