NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Homeless adults have higher rates of disease, shorter life expectancies, and higher health care utilization compared to housed individuals, all of which are partially attributable to the disproportionately high rate of harmful alcohol use in this population. This project will test the efficacy of a novel smartphone-based just-in- time adaptive intervention specifically designed to work in concert with traditional shelter-based services to address problematic alcohol use in adults experiencing homelessness in a large-scale randomized controlled trial. If effective, this low-cost and highly scalable smartphone-based intervention could significantly improve drinking outcomes, quality of life, and overall health for this highly disadvantaged population.

PI_NAMEs: BUSINELLE, MICHAEL S. (contact);OLIVER, JASON ANTHONY;WALTERS, SCOTT T

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Abstinence;acceptability and feasibility;adaptive intervention;Address;Adult;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol intervention;alcohol related problem;alcohol use disorder;Alcohols;Algorithms;Area;arm;Behavioral;Case Management;Cellular Phone;Cessation of life;Chronic;Cities;Cognitive;common treatment;comorbidity;cost;cost comparison;cost effective;Data;design;Disease;Disparity population;drinking;Ecological momentary assessment;Effectiveness;efficacy evaluation;efficacy testing;Employment;Enrollment;Ensure;Environment;ethnic minority;Evidence based intervention;Exhibits;experience;flexibility;follow up assessment;follow-up;Funding;Future;General Population;Goals;Government Subsidy;Health;health care service utilization;Heavy Drinking;High Prevalence;Homelessness;Hour;housing instability;implementation efforts;improved;indexing;Individual;insight;interest;Interpersonal Violence;Intervention;intervention effect;Life Expectancy;literacy;Machine Learning;Mediating;Mediation;Mental Health;metropolitan;mhealth interventions;Monitor;Moods;Morbidity - disease rate;mortality;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;negative mood;novel;Oklahoma;Outcome;Ownership;Participant;Persons;pilot trial;Play;Population;Population Intervention;prediction algorithm;programs;Public Health;Quality of life;racial minority;Randomized;Randomized, Controlled Trials;recruit;reduced alcohol use;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;screening;Sensitivity Training Groups;Services;Shelter facility;smartphone application;smartphone based assessment;Societies;substance use;Support Groups;Surveys;tailored messaging;Techniques;Technology;technology intervention;Testing;Time;Training;treatment as usual;treatment effect;Treatment Efficacy;Treatment outcome;Visit;Woman;Work;young adult

PROJECT_TITLE: Efficacy of a Smartphone-based Just-in-Time Adaptive Intervention to ReduceDrinking among Adults Experiencing Homelessness

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Genetics;Liver Disease;Regenerative Medicine

ORG_CITY: CHAMPAIGN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative The liver is responsible for many tasks, from metabolizing nutrients to breaking down toxicants and foreign chemicals and displays a robust sex difference in its metabolic functions. Nuclear receptor CAR, a xenosensor, regulates many of these pathways and cross talks with ERα signaling. This proposal will investigate if and how CAR regulates metabolic processes in a sex-specific and spatiotemporal manner during liver injury and regeneration.

PI_NAMEs: ANAKK, SAYEEPRIYADARSHINI  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetaminophen;Address;Alcohols;Biochemical;Biological Assay;Blood;Cell Nucleus;Cells;Chemicals;chromatin immunoprecipitation;Chromosome Pairing;chronic liver disease;combat;constitutive androstane receptor;coping;design;Drug Metabolic Detoxication;Drug Prescriptions;Epitopes;ESR1 gene;Estrogen Receptors;Exhibits;Genes;Genomics;Goals;Growth;Health Care Costs;Hepatic;Hepatic lobule;Hepatocyte;Hepatotoxicity;Heterogeneity;high throughput analysis;histological studies;Hyperactivity;Injury;insight;Knowledge;Laboratories;Link;Liver;Liver diseases;liver function;liver injury;liver metabolism;Liver Regeneration;Luciferases;Mediating;Metabolic;Metabolic Control;metabolic fitness;Metabolic Pathway;Metabolism;Microscopy;Modeling;Molecular;Mus;Natural regeneration;novel;Nuclear Receptors;Nutrient;nutrient metabolism;Pathway interactions;Physiological;Polyploidy;Population;Predisposition;prevent;Proliferating;receptor;Receptor Activation;receptor expression;recruit;regeneration potential;Regenerative capacity;Regenerative response;Regulation;Resolution;response to injury;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;spatiotemporal;Stomach;Testing;tool;toxicant;Transcript;transcriptome;transcriptomics;United States;Xenobiotic Metabolism

PROJECT_TITLE: Understanding Mechanisms that Regulate Liver Growth and Function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE STATEMENT Approximately 70-80% of Asian Americans young adults report experiencing explicit racial discrimination in the past year (e.g., harassed, or experiencing unfair treatment due to race) highlighting that racial discrimination is a common and acutely harmful experience and a significant public health problem. This will be the first study to establish how explicit, internalized, vicarious, and cumulative exposures to racial discrimination are associated with trajectory classes of alcohol use and other drugs, mental health, and physical health over the course of 36 months among U.S.-born 18–19-year-old Filipino, Korean and Indian Americans. A deeper understanding of the potential distinct and transdiagnostic power of different types of racial discrimination on a myriad of prospective health problems will provide new theoretical insights regarding the etiological pathways and developmental course of alcohol use and other drugs, mental health disorders and physical health among three marginalized Asian Am. ethnic groups.

PI_NAMEs: IWAMOTO, DEREK K (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: 19 year old;Acute;Address;age group;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol related problem;allostatic load;American;American Indian community;Anxiety;Asian;Asian Americans;Asian population;Behavior;binge drinking;Buffers;Cellular Phone;Clinical;Communities;Complex;coping;COVID-19 pandemic;critical developmental period;Development;Developmental Course;diagnostic value;Dimensions;Discrimination;drinking;Drug usage;dual diagnosis;Ecological momentary assessment;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Feeling;Filipino;Future;harassment;Hate;Health;Hearing;high risk;Incidence;Individual;insight;Intervention;Koreans;Link;Maintenance;marginalization;marginalized population;Measurement;Mental Depression;Mental disorders;Mental Health;Methods;Minority;Minority Groups;Modeling;Moods;novel;Outcome;Pathway interactions;Pharmaceutical Preparations;physical conditioning;poor sleep;Post-Traumatic Stress Disorders;Process;promote resilience;prospective;Public Health;public health relevance;Race;racial discrimination;racial identity;racial population;racism;Reporting;Research Design;Risk;Schools;Sleep;social;social determinants;Social support;Stereotyping;Subgroup;Surveys;Testing;theories;Time;Tobacco use;Underserved Population;Work;young adult

PROJECT_TITLE: Explicit, Vicarious and Internalized Racial Discrimination on Daily Associations and Long-Term Health Trajectories among Filipino, Korean, and Indian Americans

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Kidney Disease;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Chronic kidney disease affects approximately 10% of the world’s population and is marked by progressive fibrosis that leads to kidney failure. One of the main drivers of CKD progression are kidney cells that are injured but never fully recover from injury. This study is designed to investigate pathways that can trigger restoration of injured kidney cells to their healthy state.

PI_NAMEs: BROOKS, CRAIG ROBERT (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Affect;Animal Model;Award;Biological Assay;CDC2 gene;Cell Cycle Arrest;Cell Death;cell dedifferentiation;cell injury;Cells;Chronic;Chronic Kidney Failure;Clinic;Clinical;conditional knockout;cyclin G1;Cyclin-Dependent Kinases;Cyclins;Data;design;Development;Differentiation Therapy;Disease;Disease Progression;Dynamin;effective therapy;End stage renal failure;Fibrosis;Funding;G2/M Arrest;In Vitro;in vitro Model;in vivo;inhibitor;injured;Injury;Injury to Kidney;Kidney;kidney cell;Kidney Failure;Knock-out;Knockout Mice;M cell;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Morphology;new therapeutic target;novel therapeutic intervention;Pathway interactions;Phenotype;Population;prevent;Process;Profibrotic signal;promoter;Proteins;Proximal Kidney Tubules;Recovery;Renal function;repaired;Research;restoration;Role;Screening procedure;senescence;senescent cell;Testing;theories;therapeutic evaluation;tool;Translating

PROJECT_TITLE: The role of cyclin G1 and CDK5 in chronic kidney disease.

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Only approximately 5 out of 100 people with glioblastoma—the most common type of cancer that starts in the brain—are alive 5 years after diagnosis; half of all patients survive just 12-14 months. We discovered the BRD8 protein as a new target that, when depleted, could prolong survival in nearly three quarters of these deadly cancer cases: those without mutations in the p53 tumor suppressor. The project’s goal is to determine how BRD8 loss revives p53 and shuts down glioblastoma, thereby paving the way for more successful therapies for people with this devastating malignancy.

PI_NAMEs: MILLS, ALEA A. (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Ablation;Adult;Binding;Brain;brain cell;Bromodomain;cancer type;Cell Cycle Arrest;Cells;Chromatin;Chromatin Modeling;chromatin remodeling;Complex;design;Diagnosis;effective therapy;Effectiveness;effectiveness evaluation;Engineering;Epigenetic Process;epigenomics;Family;Future;Gene Expression;Genes;Genetic Engineering;Genomics;Glioblastoma;Gliomagenesis;Goals;Heterogeneity;Histologic;histone acetyltransferase;Histones;Human;improved;in vivo;inhibitor;Link;Malignant neoplasm of brain;Malignant Neoplasms;MDM2 gene;Mediating;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Nature;Non-Malignant;novel;Oncogenes;Organoids;Pathway interactions;patient derived xenograft model;Patients;personalized approach;Persons;Population;Positioning Attribute;pre-clinical;prevent;programs;Proliferating;Proteins;Publishing;Research;Resolution;Role;TP53 gene;Transactivation;Transcriptional Regulation;tumor;Tumor Suppression;Variant;Work;Xenograft Model

PROJECT_TITLE: Epigenetic re-establishment of tumor suppression in glioblastoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Clinical Research;Heart Disease;Neurosciences;Pain Research;Pediatric;Postural Orthostatic Tachycardia Syndrome;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PEDIATRICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Though POTS is common in adolescence we do not understand its cause. Since it often comes on after a trauma or infection and is often associated with chronic pain disorders like migraine or fibromyalgia, we believe the cause could lie in a part of the brain responsible for meeting the major threats of life (called the periaqueductal gray or PAG) that never gets properly reset after the threat passed. We will evaluate this theory by comparing brain connections in adolescents with POTS with those for adolescents without POTS who get a moderate to severe infection that gets better, to see if we can find evidence that the PAG is responsible for both POTS and the associated chronic pain disorders.

PI_NAMEs: CHELIMSKY, GISELA  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Absence of pain sensation;Accounting;Acute;Adolescence;Adolescent;Adolescent and Young Adult;Adult women;aged;Area;Blood Pressure;Bradycardia;Brain;brain fog;Brain imaging;Brain region;Cardiovascular system;cerebrovascular;Cessation of life;Childhood;Chronic;chronic painful condition;Classification;Clinical;cohort;comorbidity;Connective Tissue;coping;Coping Skills;Curiosities;Disabling;Disease;Dizziness;Drops;Emotional;Equipment and supply inventories;Estrogen Receptors;Etiology;Evolution;exhaust;Exhibits;Failure;Female Adolescents;Fibromyalgia;Flare;flexibility;Frequencies;functional disability;Functional Gastrointestinal Disorders;Functional Magnetic Resonance Imaging;girls;Heart Rate;heart rate variability;Hospitalization;Hour;Hypotension;Image;Immunologics;improved;Infection;Insula of Reil;Irritable Bowel Syndrome;Life;Link;mast cell;Measures;Mediating;meetings;Menarche;midbrain central gray substance;Midbrain structure;Migraine;Modeling;Motor;Muscle hypotonia;Natural History;Nausea;novel therapeutic intervention;Organ;Outcome;Pain;pain processing;pain signal;patient subsets;Patients;Peripheral;Pharmacology;Population;Postural Orthostatic Tachycardia Syndrome;Prefrontal Cortex;prospective;Prospective Studies;psychological trauma;Readiness;Recovery;Regulation;Reporting;response;Rest;Sample Size;Schools;Science;Severities;Social Development;Stimulus;Stress and Coping;Symptoms;System;Testing;theories;Tilt-Table Test;Time;Trauma;treatment response;Vagus nerve structure;Vasomotor;women subjects;Work

PROJECT_TITLE: Pediatric POTS: does a periaqueductal gray-vagus nerve interface malfunction explain the natural history with its numerous co-morbidities ?

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Overall The Mni Sota Center for Climate Change and Health will build multidisciplinary research capacity related to climate change and health as experienced by American Indian and rural communities through the innovative use of data resources and authentic engagement with communities. The goal of the Mni Sota (the Dakota word for ‘where the waters reflect the sky’) center is to be a leading research center that will characterize health impacts related to climate change and translate findings to create practical and actionable measures for climate change adaptation with a specific focus on American Indian and rural communities.

PI_NAMEs: ALEXANDER, BRUCE H. (contact);HELLMANN, JESSICA

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Affect;Agriculture;Air Pollution;American Indian Population;American Indians;Animals;Chronic;Climate;climate change;climate impact;climate zone;climate-related health;Communities;community engagement;Data;data resource;Deterioration;Development;Droughts;Ecosystem;Electronic Health Record;Ethics;Evaluation;Event;experience;extreme weather;Eye;Goals;Grant;Grief reaction;Health;health care disparity;health disparity populations;health inequalities;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Link;Measures;Mediating;Mental Health;Midwestern United States;Minnesota;minority disparity;multidisciplinary;novel;Obesity;Outcome;Personal Satisfaction;Persons;Pilot Projects;Politics;Population;Positioning Attribute;programs;Protocols documentation;Recording of previous events;Research;Research Personnel;Research Project Grants;resilience;Risk;Risk Factors;Rural;rural area;Rural Community;Rural Population;substance use;System;Translating;Universities;Vulnerable Populations;Water

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ALEXANDER, BRUCE H. (contact)

PROJECT_TERMS: Address;Agriculture;American Indian Population;American Indians;Attention;Budgets;career development;climate change;climate impact;climate science;climate zone;climate-related health;Collaborations;Communication;Communities;community based participatory research;community engagement;Data;data infrastructure;Development;Discipline;Effectiveness;Electronic Health Record;Ensure;Environment;Environmental Health;Epidemiology;Evaluation;experience;Foundations;Future;Goals;Guidelines;Health;health record;Healthcare;Impact evaluation;Indigenous;Institution;Knowledge;Measures;medical schools;member;Midwestern United States;Minnesota;multidisciplinary;Names;Persons;Pilot Projects;Population;Process;process evaluation;programs;Public Health Schools;Records;Reporting;Research;Research Personnel;Resources;Rural;rural area;Rural Community;Science;Strategic Planning;symposium;System;Translating;Universities;Water;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Project Narrative This Upper Midwest focused research core will evaluate the impact of extreme weather conditions on marginalized and disparate populations in this region and coordinate with the Mni Sota Center for Climate Change and Health to ensure culturally responsive information sharing. We will develop a new extreme weather database of heat, cold, air quality, and compound extreme events focused on the Upper Midwest and working with the Minnesota Electronic Health Records consortium, we will evaluate emerging extreme weather risks for high disparity populations including American Indians, rural residents, and individuals prescribed ‘climate sensitive’ medications. Our findings will provide powerful insight into extreme weather risks for at-risk populations in Minnesota and develop the critical partnerships with communities and healthcare providers to expand climate and health research capacity in this region.

PI_NAMEs: BERMAN, JESSE DAVID (contact)

PROJECT_TERMS: Acute;Address;Admission activity;Adrenergic beta-Antagonists;agricultural community;Air;Air Pollution;American Indian Population;American Indians;Anti-Cholinergics;Anti-Hypertensive Agents;Area;Asthma;Behavior;Blood;Canada;Cardiopulmonary;Categories;Cessation of life;Chronic Disease;Chronic Obstructive Pulmonary Disease;Climate;climate adaptation;climate change;climate impact;climate zone;climate-related health;Clinic;Clinical;clinical decision-making;Collaborations;Communities;community engagement;Community Healthcare;comorbidity;Crossover Design;Data;Data Set;Databases;Development;Disease;Disparity;Disparity population;Diuretics;Droughts;Drug Prescriptions;Electronic Health Record;Emergency department visit;Ensure;Event;Excretory function;experience;extreme heat;extreme temperature;extreme weather;Food;Frequencies;Future;Geographic Information Systems;Geography;Goals;greenhouse gases;Health;health assessment;health care availability;health data;health disparity;Health Personnel;Healthcare;Heart failure;Heat Stress Disorders;Heat Waves;high risk;Home;Hospitalization;Hyperthermia;Indigenous;Individual;Inequity;inhibitor;Injury;innovation;insight;Investigation;Knowledge;Link;Liquid substance;marginalized population;Medical;Mental Health;meteorological data;Midwestern United States;Minnesota;Minority Groups;Minority Health Research;Non-accidental;North America;novel;Occupations;Overdose;Patients;Persons;Pharmaceutical Preparations;Physiologic Thermoregulation;Play;Policies;Population;Populations at Risk;Predisposition;Privatization;Public Health;Public Health Practice;Race;Regulation;Research;Resources;response;Risk;Risk Assessment;Risk Factors;Role;Rural;rural area;Rural Community;rural dwellers;rural healthcare;Rural Population;rural residence;Secure;Services;Shunt Device;side effect;Smoke;sociodemographics;Socioeconomic Status;Source;spatiotemporal;Stroke;Suicide attempt;System;thermal stress;Translations;Tribes;Underrepresented Populations;underserved community;urban area;urgent care;Vulnerable Populations;Water;Weather;Wildfire;Work

PROJECT_TITLE: Assessing Health Impacts of Extreme Weather on American Indian, Rural Populations with Multisystem Electronic Health Records


PI_NAMEs: HILL, KYLE X (contact)

PROJECT_TERMS: Air Pollution;Alaska Native;Alaska Native population;Ally;American Indian Population;American Indians;Belief;Carcinogens;Chronic;citizen science;climate change;climate impact;climate-related health;Communities;community engaged research;community engagement;Data;Deterioration;digital;Ensure;Environment;Environmental Health;Evaluation;Event;experience;Exposure to;extreme weather;Eye;federal policy;Grief reaction;Guidelines;Health;health care availability;health disparity;Human;Indigenous;indigenous community;innovation;Institution;Knowledge;Knowledge acquisition;Lead;Link;Literature;Mental Health;Minnesota;multidisciplinary;native youth;Natural Resources;Obesity;Oral;Persons;Pilot Projects;Policy Maker;programs;Published Comment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Records;Research;Research Personnel;Research Project Grants;Risk;Rural;Rural Community;Rural Population;Science;substance use;System;Universities;Writing

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PROJECT_TITLE: Pilot Project Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Clopidogrel is a widely prescribed anti-platelet drug used to treat coronary heart disease (CAD) with known genetic variants that effect drug response. However, no study has looked comprehensively at the contributions of other multi-omic datatypes on drug response in non-European populations. The contributions of social determinants of health (SDoH) to the health outcomes of underrepresented populations with chronic conditions like CAD and who experience health disparities are also largely uncharacterized. Our study will fill these gaps with a cohort of Caribbean Hispanic clopidogrel patients and healthy controls with multi-omic data and with an evaluation of individual SDoH.

PI_NAMEs: DUCONGE, JORGE ;PERERA, MINOLI A (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Address;Admixture;Adverse event;African;Antiplatelet Drugs;Area;Assessment tool;Attention;Awareness;Blood Platelets;Cardiovascular Diseases;Caribbean Hispanic;Chronic;Clinical;clinical care;clinical translation;clopidogrel;cohort;Communities;community engagement;Computers;Coronary Arteriosclerosis;Coronary heart disease;CYP2C19 gene;Data;Data Set;Dimensions;DNA;Dose;Drug usage;Enzymes;epigenomics;Equity;European;Evaluation;experience;Gene Expression;Genes;genetic variant;Genetic Variation;Genome;genome-wide analysis;genomic data;Genomic medicine;Genomics;Health;health disparity;health equity;Healthcare;Hepatic;Hispanic;Hispanic Populations;improved;Indigenous;Individual;insight;International;Intervention;Knowledge;Measures;Methodology;Methods;methylome;model building;Modeling;Molecular;multi-ethnic;Multiomic Data;multiple omics;Oral;Outcome;Participant;Patient Care;patient engagement;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Play;Population;precision medicine;predictive modeling;Prodrugs;Public Health;Puerto Rican;Puerto Rico;Research;response;Risk Factors;Role;Single Nucleotide Polymorphism;social;social factors;social health determinants;social vulnerability;Specialist;study population;Time;tool;transcriptome;transcriptomics;translational scientist;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Social, Genomic, and Epigenomic Drivers of Clopidogrel Response in Puerto Ricans

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (M1)]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Kidney Disease;Mental Health;Pain Research;Palliative Care;Primary Health Care

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative End-stage kidney disease patients on hemodialysis experience debilitating fatigue, pain and depression, which are associated with poor health-related quality of life, increased hospitalizations and mortality. With this proposal, we will enhance our successful Technology Assisted Stepped Collaborative Care (TĀCcare) intervention for symptom management, and test effectiveness and implementation of TĀCcare 2.0 facilitated by dialysis staff in a real-world setting. If successful, this study will provide transformative evidence and a blueprint to dialysis clinics and policy makers for an integrated, scalable intervention for improving symptom burden and meaningfully changing clinical care for patients on hemodialysis.

PI_NAMEs: JHAMB, MANISHA  (contact);UNRUH, MARK LYNN

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acceleration;Address;Adherence;Advanced Malignant Neoplasm;Advocate;Alabama;Anxiety;arm;attentional control;Caring;Clinic;Clinical;clinical care;clinically significant;Cluster randomized trial;Cognitive Therapy;Collaborations;collaborative care;Collection;comparison control;comparison intervention;contextual factors;cost;debilitating symptom;design;Dialysis patients;Dialysis procedure;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;effectiveness/implementation trial;Elements;Emergency department visit;End stage renal failure;experience;Fatigue;Goals;health related quality of life;Hemodialysis;Hospitalization;Hybrids;implementation barriers;implementation context;implementation cost;implementation evaluation;implementation facilitation;implementation facilitators;implementation strategy;implementation trial;implementation/effectiveness;improved;Institution;Intervention;Interview;Kidney Diseases;Leadership;Maintenance;Measures;Mental Depression;Methods;Modeling;mortality;Nebraska;New Jersey;New Mexico;novel;Outcome;Pain;Participant;patient advocacy group;Patient Care;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Pharmacotherapy;Policies;Policy Maker;Practical Robust Implementation and Sustainability Model;pragmatic implementation;Prevalence;primary care team;primary outcome;Provider;Questionnaires;Randomized, Controlled Trials;recruit;Reporting;Research;Research Priority;Resources;Rural;secondary outcome;Severities;shared decision making;sleep quality;Surveys;symposium;Symptom Burden;symptom cluster;symptom management;symptomatic improvement;Symptoms;Technology;technology validation;Telemedicine;Tennessee;Testing;tool;treatment as usual;trial comparing;United States National Institutes of Health;urban area

PROJECT_TITLE: Technology Assisted Collaborative Care Implementation Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative A hallmark of pancreatic ductal adenocarcinoma (PDAC) is a dense extracellular stroma that reduces mass transport and inhibits immune cell infiltration into the tumor. Systemically delivered stromal targeting therapies have shown promise at extending patients’ lives; however, the clinically effective doses result in potentially fatal side effects. Our goal is to advance a local drug delivery platform for intratumoral delivery of stromal targeting therapies to improve mass transport into the tumors, providing a window of opportunity to deliver systemic chemotherapy with greater effectiveness and improve immune cell infiltration into the tumors.

PI_NAMEs: SOLORIO, LUIS  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Affect;Blood flow;Blood Vessels;Bypass;Cancer Biology;CD8B1 gene;Cells;Chemicals;chemotherapy;Clinical;clinical efficacy;Complex;controlled release;Cytotoxic T-Lymphocytes;Data;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dose;Dose Limiting;drug distribution;Drug Transport;Effectiveness;Enzymes;extracellular;Flow Cytometry;fluorescence imaging;Formulation;Genetically Engineered Mouse;Glycosaminoglycans;Goals;Histology;Human;Hyaluronic Acid;Hyaluronidase;image guided;immune cell infiltrate;immune modulating agents;Immunologic Surveillance;immunoregulation;Immunotherapy;Implant;implant design;Implantation procedure;improved;improved outcome;In Situ;Injectable;Legal patent;local drug delivery;Malignant neoplasm of pancreas;Malignant Neoplasms;mathematical model;Measures;Medical Imaging;Modeling;mortality;multi-scale modeling;neoplastic cell;novel;novel strategies;Output;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Pharmaceutical Preparations;Phase;pre-clinical;predictive tools;prevent;Property;Proteins;Recombinants;Reporting;Research;Route;Selection for Treatments;side effect;Survival Rate;System;T cell infiltration;targeted agent;targeted treatment;Therapeutic Agents;Tissues;Treatment Efficacy;treatment strategy;trend;tumor;Tumor Immunity;Tumor Volume;Ultrasonography;uptake;Work

PROJECT_TITLE: Stromal targeting to improve the efficacy of systemically administered drugs for pancreatic ductal adenocarcinomas

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Microbiome;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Public Health Relevance Although immunotherapy has become the first line of therapy in advanced patients with lung cancer, less than half of all eligible patients respond to immunotherapy. In this grant, we will uncover intratumoral microbial and immunological predictors that distinguish responders from non-responders, with the goal of identifying new targets for more effective immunotherapies. In clinical practice, these predictors could help optimize patient selection for treatment with immunotherapy and facilitate the development of precision immunotherapy.

PI_NAMEs: CHRISTIANI, DAVID C;LIU, YANHONG  (contact);SCHABATH, MATTHEW B.

PROJECT_TERMS: Algorithms;analysis pipeline;Archives;Artificial Intelligence;automated analysis;Bioinformatics;Biological;Biological Markers;Biological Specimen Banks;Biopsy;Boston;Cancer Center;Cancer Patient;cancer survival;cancer therapy;candidate identification;CD8-Positive T-Lymphocytes;Cells;cellular imaging;Characteristics;checkpoint therapy;Classification;Clinical;Clinical Data;clinical practice;Clinical Treatment;cohort;Cohort Studies;college;Core Biopsy;Core Facility;Cytometry;Dana-Farber Cancer Institute;Data;Data Set;deep learning;deep learning algorithm;Development;dysbiosis;Effectiveness;Eligibility Determination;Epidemiologist;Epidermal Growth Factor Receptor;Evaluation;Excision;experience;Formalin;Gender;Goals;Grant;gut microbiome;Histologic;Image;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immunologics;Immunologist;immunomodulatory strategy;Immunotherapy;improved;Inflammatory;insight;Institution;Interdisciplinary Study;Investigation;Joints;Link;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;Metabolic;metagenomic sequencing;Methodology;microbial;microbiome;microbiota;Modeling;multiplexed imaging;Mutation;Nature;Non-Small-Cell Lung Carcinoma;Oncologist;Outcome;Paraffin Embedding;partial response;pathogen;Pathway interactions;Patient Selection;patient stratification;Patients;personalized immunotherapy;Phase;predicting response;predictive modeling;predictive signature;programmed cell death ligand 1;Progressive Disease;prospective;Protocols documentation;public health relevance;Race;Regimen;Reporting;Research;Resistance;responders and non-responders;response;Role;Selection for Treatments;Smoking Status;Solid Neoplasm;Specimen;Stable Disease;Structure of parenchyma of lung;Subgroup;tertiary lymphoid organ;Testing;therapy resistant;Tissue Embedding;Training;Treatment Protocols;treatment response;tumor;tumor microbiome;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Validation;Work

PROJECT_TITLE: Intratumoral microbiota and immune predictors of response to immunotherapy in lung cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Cerebrovascular;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Diabetic retinopathy is characterized by progressive deterioration of retinal blood vessels and neurons in diabetes resulting in severe vision loss. The goal of this project is to elucidate a novel pathway that leads to endothelial cell dysfunction and pericyte loss in the diabetic retina and test the efficacy of a new therapy targeting this pathway for developing an effective and long-term treatment for diabetic retinopathy.

PI_NAMEs: ZHANG, SARAH X (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Animals;Apoptosis;Background Diabetic Retinopathy;BCL2L1 gene;beta-Galactosidase;bevacizumab;Blindness;Blood capillaries;Blood Platelets;Blood Vessels;Blood-Retinal Barrier;brain endothelial cell;CDKN1A gene;CDKN2A gene;Cell Aging;Cell Death;Cell secretion;Cell Senescence Induction;Cell Separation;Cell Survival;Coculture Techniques;conditional knockout;Conditioned Culture Media;Data;Deterioration;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diabetic Retinopathy;Disease Progression;Down-Regulation;effective therapy;efficacy testing;Endothelial Cells;endothelial dysfunction;Endothelium;Excision;Exhibits;extracellular;Extracellular Matrix;Extravasation;Functional disorder;Generations;Genes;Genetic;glycemic control;Goals;Grant;Human;Hydrogen;Hydrogen Peroxide;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interleukin-1 beta;intravitreal injection;Knockout Mice;laser photocoagulation;Lead;Lesion;macular edema;Mediating;Microaneurysm;mitochondrial dysfunction;Molecular;mouse model;Mus;NADPH Oxidase;Neurons;new therapeutic target;novel;Outcome Study;overexpression;oxidative DNA damage;Oxidative Stress Induction;paracrine;Pathogenesis;Pathogenicity;Pathologic;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Pericytes;Phenotype;Play;prevent;Prevention;Production;proliferative diabetic retinopathy;Protac;Proteomics;Reactive Oxygen Species;Research;Retina;retina blood vessel structure;Retinal Diseases;Retinal Neovascularization;Rodent Model;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Signal Pathway;standard care;Structure;System;systemic inflammatory response;Technology;Testing;Therapeutic;Therapeutic Effect;Tissues;Toxic effect;Transgenic Mice;Transgenic Organisms;Up-Regulation;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;vascular injury;Vascular Permeabilities;Work

PROJECT_TITLE: Molecular Mechanisms of Severe Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Hematology;Infectious Diseases;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Intra-abdominal infections (IAI) with fungi and bacteria concurrently result in worsened outcomes as compared to monomicrobial or bacterial co-infection, although the reasons are not fully understood. Our previous work to recapitulate IAI in a murine model using the fungus Candida albicans and bacterium Staphylococcus aureus as model organisms has identified Candida-induced bacterial toxin production as a key driver of pathological inflammatory responses and lethality. The major goal of this work is to delineate the host and microbial mechanisms involved in promoting lethality and altering protective trained innate immunity in order to develop better therapeutic interventions to prevent the high mortality observed during fungal-bacterial IAI.

PI_NAMEs: CASSAT, JAMES E;FIDEL, PAUL L;PETERS, BRIAN M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Abdomen;Abdominal Infection;Affect;Agglutinins;alpha Toxin;Animal Model;Antibiotic Therapy;Automobile Driving;Bacteria;Bacterial Infections;Bacterial Toxins;Blood Circulation;Blood Coagulation Disorders;Bone Marrow;Bone remodeling;Candida;Candida albicans;Cells;Clinical;co-infection;Coagulase;Coagulation Process;Control Locus;Cues;cytotoxicity;Data;Death Rate;deletion library;Disease;Disseminated Intravascular Coagulation;Epithelium;Exhibits;Functional disorder;fungus;Gastrointestinal tract structure;Goals;Gram-Positive Bacteria;Hematopoietic stem cells;Hemostatic Agents;Hemostatic function;Homeostasis;Hospitalization;Host Defense;Human;Immune;Immune response;Immune signaling;Immunosuppression;improved;improved outcome;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Intervention;intestine surgery;Intra-abdominal;Invaded;Kinetics;Laboratories;Luciferases;Measures;Mediating;Medical Device;Metabolism;Microbe;microbial;model organism;Modeling;mortality;mouse model;mutant;Mycoses;Myeloid-derived suppressor cells;Natural Immunity;novel;Organ;Organism;Outcome;Pathogenesis;pathogenic bacteria;pathogenic fungus;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Plasma;polymicrobial sepsis;Population Dynamics;prevent;Production;Prothrombin time assay;quorum sensing;Relapse;Reporter;Research;response;Ribose;Risk Factors;Role;Sepsis;Signal Pathway;Staphylococcus aureus;stem cell population;synergism;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Toxin;Training;transcription factor;transcriptome sequencing;Up-Regulation;Virulence;Virulence Factors;Work

PROJECT_TITLE: Fungal-bacterial dynamics driving dysregulated host responses and lethal synergism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Hematology;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Pediatric Cancer;Peripheral Neuropathy;Prevention;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition that occurs in up to 87% of children treated with chemotherapy and often persists in long-term childhood cancer survivors. CIPN is particularly challenging to identify in young children because there are no validated instruments to measure CIPN in children less than five years old, even though 40% of children at risk for CIPN are in this age group, and early intervention can improve their symptoms. The overarching goal of this proposal is to develop a patient-centered clinician-guided instrument to screen for CIPN in young children and collect preliminary data to inform future implementation.

PI_NAMEs: RODWIN, ROZALYN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: 5 year old;Acute;Acute Lymphocytic Leukemia;Address;Affect;Age;age group;Award;Cancer Survivorship;cancer therapy;career;Caring;chemotherapy;Chemotherapy-induced peripheral neuropathy;Child;Child Care;Childhood;childhood cancer survivor;clinical practice;cognitive interview;Connecticut;Consolidated Framework for Implementation Research;Data;Development;Diagnosis;Early Diagnosis;Early identification;Early Intervention;Emotional;Equilibrium;experience;Feedback;follow-up;Foundations;Functional impairment;Future;future implementation;Goals;group intervention;Health;Impairment;implementation determinants;implementation science;improved;indexing;Individual;Institution;instrument;Intervention;Interview;Knowledge;Late Effects;Learning;Long-Term Survivors;Malignant Childhood Neoplasm;Measures;Medical;medical schools;Mentors;Mentorship;Methods;Motor;Multicenter Trials;multidisciplinary;Musculoskeletal;Neurologic Examination;novel;Oncology;Outcome;Parents;patient oriented;Patients;Pediatric Hematology;Pediatric Oncology;Pediatric Oncology Group;Peripheral Nervous System Diseases;Physical Function;Physical therapy;Physicians;Platinum;professor;Property;prospective;prototype;Provider;Proxy;Psychometrics;Qualitative Methods;Qualitative Research;Quality of life;Reporting;Research;Risk;Sampling;Scientist;screening;Screening procedure;Siblings;side effect;Site;skills;Surveys;survivorship;symptomatic improvement;Symptoms;Techniques;Time;Toxic effect;Training;Training Activity;Treatment-related toxicity;United States;Validation;Vinca Alkaloids;virtual;Walking;Work;Writing

PROJECT_TITLE: Development of a novel survey to screen for chemotherapy-induced peripheral neuropathy in young children

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Strategies to improve interdisciplinary communication that are responsive to needs in low resource settings are needed to improve childhood cancer globally. This project identifies determinants of communication in low resource settings prior to co-developing and testing interventions with staff from these impacted settings. When completed, this study will produce evidence informed, multilevel interventions to improve team communication during patient deterioration, advancing the science of multidisciplinary communication during cancer care, and ultimately improving survival for children with cancer globally.

PI_NAMEs: MALONE, SARA  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Address;burnout;cancer care;Cancer Hospital;cancer therapy;care delivery;Child Care;childhood cancer mortality;Client satisfaction;Clinical;clinical care;cohort;Communication;Communication difficulty;control trial;Critical Care;Data;Decision Making;Deterioration;Effectiveness;Evaluation;Event;Excess Mortality;Face;feasibility testing;Goals;health care delivery;health equity;Hospitals;Human Resources;implementation science;improved;Individual;innovation;Interdisciplinary Communication;Intervention;intervention effect;intervention mapping;Interview;Knowledge;Language;Length of Stay;Linguistics;low and middle-income countries;Malignant Childhood Neoplasm;Maps;Measurable;Measurement;Measures;Medical Errors;Methods;Modernization;Multilingualism;novel;Nurses;Oncology;Outcome;Pathway Analysis;Patient Care;patient safety;Patient-Focused Outcomes;Patients;Pattern;Pediatric Oncology;Physicians;pilot test;Positioning Attribute;pressure;primary outcome;Procedures;Professional Role;Provider;psychologic;Randomized;Randomized, Controlled Trials;Research Methodology;Resource-limited setting;Resources;Safety;Saint Jude Children's Research Hospital;Science;secondary outcome;Social Network;Structure;Survival Rate;System;Testing;Time;tool;tumor;usability;Waiting Lists;Work

PROJECT_TITLE: Strategies to Improve Communication Structure and Quality in Low-resource Childhood Cancer Hospitals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


PHR: PROJECT NARRATIVE The use of antibiotics in the first year of life has been recognized as a strong, consistent, and modifiable risk factor for the development of asthma in childhood in numerous individual studies and several meta-analyses. The goals of this proposal are 1) to determine the age when infants are most susceptible to the harmful consequences of antibiotics on childhood asthma risk, 2) to examine microbial pathways through which infant antibiotic exposure could lead to childhood asthma, and 3) to identify early-life upper respiratory tract and gut bacterial species, patterns, and/or products that could increase the resilience of these 2 microbial communities and be protective for childhood asthma onset after infant antibiotic exposure. By identifying a critical window of opportunity to intervene, the microbial pathways to target, and candidate probiotics and/or bacterial products, the ultimate goal of the planned studies is to inform the design of microbiome-based therapeutics that can help deliver antibiotics safely during early life and reduce the burden of childhood asthma.

PI_NAMEs: ROSAS-SALAZAR, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;administrative database;Age;Antibiotics;Asthma;bioinformatics pipeline;Biological Assay;Birth;candidate identification;Child;Childhood;Childhood Asthma;cohort;Collaborations;Collection;Complex Variables;cost efficient;Data;design;Development;Early identification;Enrollment;Exposure to;Goals;gut microbiome;Health Information System;Human;Human Microbiome;Individual;infancy;Infant;Institution;Knowledge;Laboratories;Lactobacillus;Life;Longitudinal Studies;Mediating;Meta-Analysis;metabolomics;Metagenomics;metatranscriptomics;microbial;microbial community;microbiome research;microbiome therapeutics;modifiable risk;Nose;Outcome;Pathway interactions;Pattern;population based;Predisposition;prevent;Probiotics;promote resilience;prospective;Randomized, Controlled Trials;Research;Research Design;respiratory health;respiratory microbiome;Risk;Risk Factors;Route;Sampling;stool sample;Structure;Taxonomy;Techniques;Testing;therapy design;Upper respiratory tract

PROJECT_TITLE: Effect of infant antibiotics on the development of the early-life airway and gut microbiome and risk of childhood asthma

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PHR: PROJECT NARRATIVE Greater than 75% of the human genome is transcribed, yet only 2% of genomic sequence is transcribed into protein coding RNA transcripts. Estimates suggest 50-90% of disease-causing mutations are located within noncoding sequences, suggesting non-protein coding RNA transcripts significantly contribute to disease pathogenesis. Upon completion, our study will provide insights into the mechanisms by which noncoding RNA transcripts regulate retinal development and visual function, including providing insights into the prevalence and function of transcription factors binding to RNA.

PI_NAMEs: CLARK, BRIAN S (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affinity;Age related macular degeneration;Architecture;ATAC-seq;Binding;Biological;Biology;Cell Death;cell fate specification;Cell Nucleus;Cell Shape;cell type;Cells;Chromatin;chromatin isolation by RNA purification sequencing;Cleavage Under Targets and Release Using Nuclease;Code;Competence;Complex;Data;Defect;Development;digital;Disease;disease-causing mutation;DNA;Electroporation;EMSA;Encapsulated;Epigenetic Process;Exhibits;experimental study;gain of function;Gene Expression;gene regulatory network;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;GTF2I gene;Guide RNA;Heritability;Human;Human Genome;Immunoprecipitation;in vivo;insight;Knowledge;Ligation;loss of function;Mediating;Modeling;Molecular;Mus;mutant;Mutation;notch protein;novel;Pathogenesis;Phenotype;Photoreceptors;Play;Precipitation;Prevalence;programs;Proliferating;Proteins;Regulation;Retina;Retinal Diseases;retinal progenitor cell;retinal rods;RNA;RNA Binding;Role;scaffold;single-cell RNA sequencing;Site;Specific qualifier value;Stem Cell Development;Synapses;Techniques;Testing;Tissues;trait;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;Untranslated RNA;Validation;Viral;Vision

PROJECT_TITLE: Regulation of Retinal Development by RNA molecules

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Children’s Interstitial and Diffuse Lung Diseases (chILD) pose significant burdens on thousands of children across the U.S., yet for most, the genes causing chILD have not yet been identified. This project aims to define genetic landscape of chILD to inform the development of more specific and biologically rational therapies for these disorders. Our approach combines in situ transcriptomic profiling, whole exome-sequencing, and network-based analytical approaches to map novel chILD-causing genes.

PI_NAMEs: RABY, BENJAMIN ALEXANDER (contact);YOUNG, LISA R.

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: ABCA3 gene;Acceleration;Address;Adult;Affect;Alveolar Macrophages;Appearance;biobank;Biochemical;Biological;Biopsy Specimen;Boston;causal variant;CD3 Antigens;Cd68;cell type;Cells;Child;Childhood;Chromosome Mapping;Clinic;Clinical;Clinical Management;clinically significant;cohort;Computational Biology;cost;Data;database of Genotypes and Phenotypes;Databases;Development;Diagnosis;Diffuse;Disease;disorder subtype;DNA Sequence;early childhood;Enrollment;Etiology;Exhibits;exome;exome sequencing;experience;Family;gene discovery;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic disorder diagnosis;Genetic Variation;genomic profiling;genomic signature;Genomics;Genotype;Goals;Healthcare Systems;Heterogeneity;Histologic;Histopathology;Homeostasis;human interactome;improved;In Situ;infancy;informatics infrastructure;Infrastructure;Inheritance Patterns;insight;Institution;Institutional Review Boards;interstitial;Interstitial Lung Diseases;loss of function;Lung;Lung Diseases;Lymphocyte;Macrophage;Maps;Methods;Modeling;Molecular;Molecular Diagnosis;Molecular Disease;Molecular Profiling;Morbidity - disease rate;mortality;mRNA Expression;Mutation;Network-based;novel;offspring;Outcome;Parents;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Penetrance;Phenotype;Philadelphia;pneumocyte;population based;Process;Property;protein expression;Protocols documentation;rare variant;Registries;Research;research clinical testing;Sample Size;Sampling;screening;Siblings;Standardization;Structure of parenchyma of lung;success;targeted treatment;Testing;therapeutic target;tool;Training;Trans-Omics for Precision Medicine;transcriptomic profiling;transcriptomics;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project narrative Distinguish RORyt function in Th17 cells and thymocytes by characterizing its common and unique co-factors in these two types of cells.

PI_NAMEs: SUN, ZUOMING  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Autoimmune Diseases;Autoimmunity;Bacteria;CBFB gene;Cell Compartmentation;Cell Physiology;cell type;Cells;cofactor;Collaborations;Development;Experimental Autoimmune Encephalomyelitis;Gene Deletion;Gene Expression;gene function;Generations;Genetic Transcription;Goals;IL17 gene;Immune response;Immune system;Immunity;in vivo;Infection;Inflammatory Bowel Diseases;inhibitor;innovation;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mediating;Medical;Mouse Strains;Multiple Sclerosis;Mus;mutant;novel;Oncogenes;Orphan;pathogen;Pathogenicity;Pathologic;Peripheral;pharmacologic;prevent;programs;Psoriasis;Reagent;receptor;receptor binding;receptor function;Receptor Inhibition;Records;recruit;Retinoids;side effect;skills;success;T-Cell Development;T-Lymphocyte;targeted treatment;Therapeutic;Thymic Lymphoma;thymocyte;Thymocyte Development;Tissues;transcription factor;Tumor Suppressor Genes;Virus;Work

PROJECT_TITLE: Cbfb in RORgt-regulated T cell function

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE This research aims to understand programmed cell death/survival in mouse models of retinal degeneration and to identify cellular pathways that promote cell survival. Living-color reporters named CaspBiosensors will be used to identify cells that will eventually die (vulnerable) and other cells that are reverse their death signal (resilient). The cellular and molecular features of these vulnerable/resilient cells will be investigated to inform the development of neuroprotection therapies.

PI_NAMEs: CHEN, SHIMING  (contact);WILLIAMS, PHILIP RAYMOND

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Animals;Apoptosis;Apoptotic;Appearance;Basic Science;Blindness;Candidate Disease Gene;candidate selection;CASP3 gene;Cell Death;Cell Survival;Cells;Cellular biology;cellular resilience;Cessation of life;Chronic;Color;cone-rod dystrophy;Data;Development;Disease;effective therapy;Equilibrium;experimental study;Fluorescence;gain of function;Gene Expression;gene therapy;gene therapy clinical trial;Genes;Genetic;Genetic Complementation Test;Genetic Diseases;Grant;Histologic;Histology;Image;improved;in vivo;in vivo imaging;Individual;inherited retinal degeneration;Intervention;Knowledge;Label;Life;Light;loss of function;Measures;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Mutation;Names;Nerve Crush;Neurons;neuroprotection;novel therapeutic intervention;Optic Nerve;Outcome;Outcomes Research;Pathway interactions;photoreceptor degeneration;Photoreceptors;Population;preservation;prevent;Process;Proteins;Reagent;Recovery of Function;repaired;Reporter;Reporting;Research;resilience;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Retinitis Pigmentosa;Rod;Signal Pathway;Signal Transduction;single-cell RNA sequencing;survival outcome;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;tool;transcriptomics;Vertebrate Photoreceptors;Visual

PROJECT_TITLE: Vulnerable and Resilient Cells in Retinal Degeneration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Patient Safety;Rare Diseases

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE This proposal will focus on the development of novel technology for ultra-fast, high-resolution, and noncontact quantification of corneal biomechanical properties in 3D. The development of such a technique would significantly advance our understanding of corneal disorders, enable the development of personalized clinical therapies and interventions, and improve outcomes of current surgical and therapeutic interventions.

PI_NAMEs: AGLYAMOV, SALAVAT R;LARIN, KIRILL V (contact);TWA, MICHAEL D

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Agreement;Air;Animals;artificial intelligence algorithm;Biological;Biomechanics;Cataract Extraction;Characteristics;Clinic;Clinical;clinical diagnosis;clinical diagnostics;Clinical Protocols;clinical translation;Clinical Treatment;Cohort Studies;Cornea;Corneal Diseases;corneal epithelial wound healing;corneal surgery;Coupled;crosslink;Dependence;design;Detection;Development;Diagnostic;Diagnostic tests;Discipline;Disease;Elasticity;elastography;Eye;Eye diseases;Glaucoma;Goals;Human;Iatrogenesis;Image;imaging modality;improved;improved outcome;in vivo;Individual;Intervention;Keratoconus;Knowledge;Laser In Situ Keratomileusis;Link;Maps;Measurement;Measures;mechanical properties;Mechanics;Methods;millisecond;Modulus;Myopia;Nature;new technology;next generation;novel;novel strategies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Outcome;Pathologic;Pathology;Patients;personalized medicine;physical property;Physiologic Intraocular Pressure;Physiological;Property;Reporting;Research;Resolution;response;Severities;Spatial Distribution;Staging;Structure;success;Techniques;Technology;Therapeutic;Therapeutic Intervention;Thick;Three-Dimensional Imaging;Time;Tissue Transplantation;Tissues;tool;Translating;Treatment outcome;treatment response;Tunic;ultrasound;Validation;viscoelasticity;Viscosity;Vision;Work

PROJECT_TITLE: Optical Coherence Elastography of the Cornea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Prevention;Sleep Research

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: A proliferation of wearable devices and machine learning approaches has led to exciting advances in automated assessment of sleep, physical activity, and sedentary behavior in real-world environments. These methods, however, have been predominantly developed and validated with adults and older children, and they do not readily transfer to assessment of infant functioning in these key health domains. We aim to fill this gap by (a) leveraging high-density multimodal data collected from a wearable device designed specifically for infants and (b) developing deep learning algorithms to detect infant sleep/wake states, physical activity/sedentary behavior, and household soundscapes.

PI_NAMEs: HASEGAWA-JOHNSON, MARK ALLAN;MCELWAIN, NANCY L (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adolescent;Adopted;Adult;Age Months;Algorithms;Attention;automated assessment;awake;Behavioral;Brain;Car Seats;Cardiac;Certification;Child;Child Development;Cognitive;Crying;Data;Data Science;deep learning;deep learning algorithm;deep learning model;density;Detection;Development;Device Designs;Devices;Drowsiness;Early Diagnosis;Early Intervention;Ecological momentary assessment;Electrocardiogram;Engineering;Environment;Environmental Risk Factor;Exertion;experience;experimental study;Exposure to;Foundations;Grain;Growth;Guidelines;Health;Health behavior;health equity;high risk;Home;Home environment;Home visitation;Hour;Household;Human;Illinois;Individual;infancy;Infant;Infant Health;innovative technologies;Intervention;Label;laboratory development;Lead;Learning;Life;life span;Link;Loudness;Machine Learning;Manuals;Measurement;Measures;Mental Health;Methodology;Methods;microphone;Mind;mobile sensing;Modeling;Monitor;Motion;multimodal data;multimodality;Music;National Institute of Diabetes and Digestive and Kidney Diseases;Neurobiology;Noise;non rapid eye movement;Obesity;Outcome;Parents;Participant;Phase;Physical activity;physical conditioning;Physiological;Physiology;Polysomnography;poor health outcome;poor sleep;Population;Posture;primary caregiver;Process;Proliferating;Prone Position;rapid eye movement;Recommendation;Records;Reporting;Research;Research Personnel;Resources;restraint;Risk;Sampling;School-Age Population;Scientific Advances and Accomplishments;sedentary;sedentary lifestyle;self supervised learning;sensor;Sensory;Shapes;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sound;Source;Strategic Planning;Supination;System;Testing;Time;tool;Training;training data;Universities;Validation;wearable device;World Health Organization

PROJECT_TITLE: Automated Assessment of Infant Sleep/Wake States, Physical Activity, and Household Noise Using a Multimodal Wearable Device and Deep Learning Models

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The overall goal of this proposal is to create and calibrate visual activities in virtual reality that will measure how well people with poor eyesight can use their vision, by estimating the difficulty of each activity in a large group of individuals with different levels of vision loss. They will perform these activities while wearing a head- mounted display and using vision alone, but also when enriching the activity with sound and/or touch. We will choose the activities on the basis of patients’ ratings of what is important and difficult for them due to vision loss, and compare participants’ performance of some of the activities in virtual reality the real world.

PI_NAMEs: DAGNELIE, GISLIN  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Activities of Daily Living;Address;Advocate;Auditory;auditory feedback;blind;Blindness;Calibration;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;college;Country;Custom;Data;Data Analyses;Development;Diameter;Dimensions;Discrimination;Educational workshop;Environment;Equipment and supply inventories;experience;Factor Analysis;flexibility;Focus Groups;Goals;Group Meetings;Hand;haptic feedback;haptics;head mounted display;Individual;information gathering;instrument;Investigation;Language;Life;Measurement;Measures;Medical;Medicine;Methods;Modality;multisensory;New York;Ophthalmology;Optometry;Outcome;Outcome Study;Panthera leo;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Peripheral;Persons;pilot test;Population;Process;Program Development;Property;Psychometrics;Publications;Questionnaires;Reading;Rehabilitation Centers;Reproducibility;Research;Research Personnel;Respondent;Role;Sensory;Site;sound;Standardization;Stimulus;Tactile;Testing;Time;tool;Touch sensation;trend;Universities;Validation;virtual reality;virtual reality headset;Vision;vision rehabilitation;Vision research;Visit;Visual;Visual Acuity;Visual impairment;visual information;visual performance;visual tracking;way finding

PROJECT_TITLE: Low Vision Assessments in Virtual Reality (LVAVR)


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed research is highly relevant to public health because it will provide critical data on the pathways between disclosure and helping receipt for one’s own self-directed violence (SDV) as well as helping after exposure to SDV by family or peers. Importantly, this study will also identify how one’s own SDV combined with exposure to SDV may be differentially impacting the helping behaviors and the impact of such behaviors over time for sexual and gender minority as well as racial/ethnic minority populations, information key to designing more helpful suicide prevention strategies that bridge two threads of prevention (increasing protective factors for both at-risk groups and those exposed who can be active gatekeepers). As a result, we would expect decreased morbidity from SDV, improved quality of life for SDV youth and their friends and families, and a widespread reduction in medical costs associated with SDV.

PI_NAMEs: BANYARD, VICTORIA L;MITCHELL LEMA, KIMBERLY J (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: aged;Agreement;Attitude;Behavior;Cessation of life;Cognitive;cohort;Complex;Data;Data Collection;Depressed mood;design;Disclosure;Effectiveness;Enrollment;ethnic minority;ethnic minority population;Ethnic Origin;experience;Exposure to;Family;Family Violence;Feeling;Feeling suicidal;Friends;Funding;Gatekeeping;Gender;gender minority;health disparity;help-seeking behavior;Helping Behavior;improved;Income;Injury;Interpersonal Violence;Intervention;Interview;Lifting;Link;Longitudinal Studies;marginalization;Measurement;Measures;Medical Care Costs;minority children;Modeling;Morbidity - disease rate;National Institute of Mental Health;National Longitudinal Survey of Youth;non-suicidal self injury;parent grant;Participant;Pathway interactions;peer;Perception;Persons;Populations at Risk;Prevention;Prevention strategy;Process;programs;prospective;protective factors;Public Health;Published Comment;Quality of life;Race;racial minority;racial minority population;Reaction;Reporting;Research;response;Risk;Sampling;Self Direction;Self Disclosure;Sexual and Gender Minorities;sexual minority;social;social determinants;social stigma;Source;structural health determinants;Structure;Subgroup;Suicide attempt;Suicide prevention;Surveys;Teenagers;Time;timeline;trend;Violence;violence prevention;wasting;young adult;Youth;youth violence

PROJECT_TITLE: Understanding Bystanders for Self-Directed Violence Prevention: A Prospective National Study Highlighting Marginalized Youth and Young Adults

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE There is a significant racial disparity in lung cancer. In this proposal, we will characterize somatic drivers and biomarkers in lung cancer patients of African ancestry and identify new immunotherapy biomarkers. These studies will improve our knowledge about lung cancer for this patient population.

PI_NAMEs: ZHANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: actionable mutation;African American;African American population;African ancestry;Automobile Driving;Biological;Biological Markers;Biometry;cancer care;Cancer Etiology;cancer genome;cancer genomics;Cancer Patient;cancer survival;Cessation of life;Clinical;Clinical Data;Clinical Research;Clinical Trials;clinically actionable;clinically relevant;cohort;Cohort Studies;Complex;computational pipelines;Computing Methodologies;Coupled;Data;deep learning model;Disparity;DNA Sequence Alteration;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidermal Growth Factor Receptor;European ancestry;Frequencies;Future;Genetic;genome sequencing;genome-wide analysis;Genomic Instability;genomic profiles;Genomics;Germ Lines;Germ-Line Mutation;health disparity;Heritability;high risk;Immune checkpoint inhibitor;Immunotherapy;improved;insight;Institution;Knowledge;KRAS2 gene;Light;Link;Machine Learning;Malignant neoplasm of lung;Measures;Medical Oncology;Meta-Analysis;Methods;Molecular;Molecular Profiling;Mutation;never smoker;next generation sequencing;non-genetic;non-smoker;novel;novel marker;novel therapeutic intervention;Outcome;outcome prediction;Pathogenesis;patient population;Patients;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Prevalence;racial disparity;research study;response;Risk;Role;ROS1 gene;Smoker;Smoking;smoking exposure;Smoking Status;Specificity;structural determinants;targeted treatment;Testing;Therapeutic;therapeutic target;TP53 gene;transcriptome sequencing;treatment strategy;tumor;Underserved Population;whole genome

PROJECT_TITLE: Understanding lung cancer genomics in patients of African ancestry

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHIATRY

PHR: NARRATIVE A significant fraction of cases of neurodevelopmental disorders (NDD) are caused by coding mutations that prematurely terminate the translation of specific RNAs into proteins. However, protein production can also be disrupted by mutations in the untranslated regions (UTRs) of RNAs. We propose to detect and analyze new NDD mutations by bringing to bear a unique set of tools specifically designed to study translational regulation by UTRs, extending the utility of ongoing efforts to sequence the genomes of tens of thousands of NDD cases across the US and the world.

PI_NAMEs: DOUGHERTY, JOSEPH D (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Address;Affect;algorithm training;American;Autism Diagnosis;autism spectrum disorder;autistic children;Bioinformatics;Biological Assay;Brain;Categories;Cell Line;cell type;Clinical;clinical practice;Code;Complication;Copy Number Polymorphism;cost;Data;de novo mutation;design;Disease;disease-causing mutation;Exclusion;exome sequencing;Exons;Family;follow-up;Future;Gene Mutation;Genes;Genetic;genetic disorder diagnosis;Genetic Enhancer Element;Genetic Transcription;Genetic Variation;Genome;genome sequencing;Goals;Heritability;high throughput screening;in vivo;Individual;innovation;Intercistronic Region;Introns;Investments;loss of function;loss of function mutation;machine learning algorithm;machine learning model;Messenger RNA;Meta-Analysis;MicroRNAs;Missense Mutation;Mus;Mutation;Neurodevelopmental Disorder;Neurons;Neurosciences Research;Patients;Play;Population;premature;proband;Production;prognostic;promoter;Proteins;Reporter;Research;Risk;RNA;RNA Stability;RNA-Binding Proteins;Role;Symptoms;Syndrome;Testing;tool;Training;training data;Transcript;Translational Regulation;Translations;Triplet Multiple Birth;Untranslated Regions;Untranslated RNA;Update;Variant;whole genome

PROJECT_TITLE: HIGHLY PARALLEL ANALYSIS OF 5' AND 3' UTR VARIANTS IN NEURODEVELOPMENTAL DISORDERS

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Diffusion MRI (dMRI) has contributed immensely to our understanding of the white matter structure at large-to- medium spatial scales, and more recently towards smaller structures, particularly in the cortical and subcortical regions, as submillimeter dMRI is starting to become more feasible. Nonetheless, further increase in resolution is required to move dMRI to the mesoscopic scale, to improve sensitivity to small but important brain microstructural features and provide improved capability for many current clinical and neuroscientific investigations and open doors to entirely new ones. In this proposal, we aim to develop imaging technologies to allow mesoscale dMRI and extend our development to enable mesoscale joint diffusion-relaxometry MRI with rich information, to improve tractography’s robustness and enhance capability to extract detailed microstructural information. Optimized protocols will be developed for high-end clinical 3T MRIs to enable wide deployment of our technology, and on high-performance head-only 3T MRIs to enable neuroscientific explorations at the limit.

PI_NAMEs: RATHI, YOGESH ;SETSOMPOP, KAWIN  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Adoption;Aging;Binding;Brain;Clinical;clinical application;Compensation;connectome;Cortical Dysplasia;Data;Data Set;Deep Brain Stimulation;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Epilepsy;Fiber;Fingerprint;Funding;gray matter;Head;Human;Image;Imaging technology;improved;in vivo;Infarction;Investigation;Joint repair;Joints;Least-Squares Analysis;Magnetic Resonance;Magnetic Resonance Imaging;Maps;millimeter;Minor;multidimensional data;Nervous System Disorder;neural;neural network;Neurologic;next generation;Performance;Physiologic pulse;Protocols documentation;reconstruction;Relaxation;Research Institute;Resolution;Sampling;Scanning;Slice;spectroscopic imaging;Structure;Technology;Time;Tissues;tractography;Training;Uncertainty;virtual;white matter

PROJECT_TITLE: Next generation in-vivo diffusion imaging at submillimeter resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EITA-J (90)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: We will define how the conserved Bicaudal-C RNA binding protein selects mRNA substrates and regulates their expression to control critical cell-fate decisions in a model vertebrate. Bicc1 is highly conserved in all vertebrates, including humans, where it essential for normal development as well as the function of organ systems in adults, but little is known about the molecular mechanisms that define Bicc1 functions. Because a molecular understanding of Bicc1 is fundamental to advancing several biomedically relevant research areas, including our understanding of complex diseases that affect a substantial fraction of the population, the proposed research is highly relevant to public health.

PI_NAMEs: SHEETS, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Address;Adult;Affect;Affinity;Amino Acids;Animals;Architecture;Area;Behavior;Binding;Binding Sites;Biological;Biological Assay;Body System;cell fate specification;cell type;Cells;citrate carrier;Complex;Conserved Sequence;Coupled;Data;Defect;Development;Disease;Dissection;domain mapping;Embryo;Embryology;Eukaryota;experimental study;extracellular;Functional disorder;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Goals;Growth and Development function;Health;Human;KH Domain;Knock-out;Knowledge;Link;Maps;Messenger RNA;model organism;Modeling;Molecular;Molecular Genetics;mRNA Expression;mRNA Translation;multidisciplinary;mutant;Names;Nature;Nervous System;Nucleotides;Organism;Outcome;Phase;Population;posttranscriptional;Process;Protein Biochemistry;protein crosslink;protein expression;Proteins;Public Health;Reporter;Repression;Research;Resolution;response;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;Signal Transduction;Site;stem;Surface;System;Translational Regulation;Translational Repression;Translations;Variant;Vertebrates;Work;Xenopus;xenopus development;Xenopus laevis

PROJECT_TITLE: Mechanisms of mRNA-selective control by Bicaudal-C

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE In this project, we propose to develop a technique to dynamically image the lung using 129Xe MRI during free- breathing; in addition to enabling a more physiologically accurate assessment of lung function compared to current imaging techniques performed during breath-hold, this method will be feasible in patient populations that have thus far been inaccessible to functional lung imaging with polarized gas due to poor breath-hold tolerance, such as young children, those with end-stage lung disease, etc. Finally, we will establish the repeatability and sensitivity of this technique in both healthy subjects and at-risk smokers / early COPD patients.

PI_NAMEs: KADLECEK, STEPHEN J;RIZI, RAHIM R (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 3-Dimensional;Age;age related;Air Movements;analytical method;Assessment tool;Behavior;Blood;Blood capillaries;Blood flow;Blood gas;Blood Volume;Breathing;Cardiac;Child;Childhood;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical application;clinical implementation;Clinical Markers;Comprehension;contrast imaging;Coughing;density;design;Development;Devices;Diagnosis;Diffusion;Disease;Disparate;Dyspnea;Evaluation;face mask;Functional disorder;Functional Residual Capacity;Gases;Goals;Graft Rejection;healthy aging;Homeostasis;idiopathic pulmonary fibrosis;Image;image registration;imaging approach;imaging modality;Imaging Techniques;Inhalation;Investigation;Life;Long COVID;Lung;Lung Diseases;lung imaging;lung volume;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modality;Morphologic artifacts;Noise;novel;novel marker;Organ;Organism;Pathologic;Pathology;patient population;Patients;Periodicity;Physiologic pulse;Physiological;Population;pressure;Protocols documentation;pulmonary function;pulmonary vascular disorder;Reproducibility;Resolution;respiratory;response;Risk;seal;Signal Transduction;Smoker;Smoking;Syndrome;System;Techniques;Testing;Tidal Volume;Time;Tissues;Trachea;Training;trend;Tube;Uncertainty;uptake;vascular abnormality;ventilation;Visualization;Work

PROJECT_TITLE: Dynamic imaging of lung function in free-breathing subjects

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative Programmable genome modification using the CRISPR-Cas9 gene editing system has enormous therapeutic potential for rescuing gene function in individuals bearing mutations that cause inherited diseases like Duchenne Muscular Dystrophy (DMD); yet, introduction of bacterial Cas9 protein into mammals can trigger an immune response, which may pose a barrier to the use of this system for human gene therapy. This project will investigate how the immune response to Cas9 affects gene editing in a mouse model of DMD, by assaying differences in the relative rates of therapeutic gene modifications, as well as potentially deleterious mutations, in mice with intact or disrupted immune systems. Results from this work will aid evaluation of the efficiency, durability and safety of in vivo gene editing for DMD, and inform the design of future clinical approaches that utilize CRISPR-Cas9.

PI_NAMEs: SERWOLD, THOMAS F (contact);WAGERS, AMY JO

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: adaptive immune response;adeno-associated viral vector;adenovirus mediated delivery;Affect;Animals;Antibodies;Antigens;Bacteria;Becker Muscular Dystrophy;Biological Assay;Birth;Canis familiaris;Cardiac Myocytes;cell type;Cells;Cellular Immunity;Clinic;Clinical;clinical application;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Data;Deletion Mutation;Dependovirus;design;Development;Disease;disease-causing mutation;DNA;DNA Damage;Duchenne muscular dystrophy;Dystrophin;efficacious treatment;endonuclease;Engineering;Evaluation;Event;Excision;exon skipping;Exons;experimental study;Frequencies;Future;gene correction;Gene Deletion;gene editing technology;gene function;Gene Modified;gene therapy;Gene Transfer;gene-editing approach;Genes;Genetic;Genome;genome editing;Genomics;genotoxicity;Guide RNA;Heart;Hereditary Disease;Human;human stem cells;humanized mouse;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunosuppressive Agents;in vivo;Individual;Infection;Inherited;interest;Knowledge;Lead;Lesion;male;Mammals;mdx mouse;Mediating;Modification;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;muscle progenitor cell;Muscular Atrophy;mutant;Mutation;Myocardium;Myopathy;Nature;nonhuman primate;novel strategies;nuclease;Organ;Orthologous Gene;Paper;Pathway interactions;Patients;pharmacologic;prevent;Production;progenitor;Proteins;Publishing;Reading Frames;Recovery;regenerative;repaired;Reporting;resilience;Resources;response;restoration;Risk;Risk Assessment;Safety;Series;Severities;Site;Site-Directed Mutagenesis;Skeletal Muscle;Structural Protein;System;T cell response;Testing;Therapeutic;therapeutic gene;therapeutic genome editing;therapy outcome;Time;Tissues;tool;Toxic effect;Transgenes;Treatment-related toxicity;Wasting Syndrome;Work

PROJECT_TITLE: Modulating the adaptive immune response to enhance the efficiency of in vivo gene editing in muscle

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Genetics;Human Genome;Infertility;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Maternal obesity in reproductive-age women continues to increase and is more likely to result in a poor response to infertility treatment and adverse pregnancy outcomes. In the proposed work, we will leverage a nonhuman primate maternal obesogenic diet model to investigate the underlying epigenetic mechanisms mediating embryo and fetal programming and how an obesogenic diet negatively impacts these processes prior to birth.

PI_NAMEs: CARBONE, LUCIA ;CHAVEZ, SHAWN L. (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Acceleration;Adverse effects;adverse pregnancy outcome;Affect;Age;Back;Birth;bisulfite sequencing;blastocyst;Body mass index;Body Weight decreased;Carbohydrates;Cells;Center for Translational Science Activities;Chromosomes;cohort;comparison control;Conceptions;Consumption;Control Groups;Copy Number Polymorphism;Data;Defect;Development;Developmental Delay Disorders;Diet;dietary;dietary control;Dietary Intervention;DNA;DNA Maintenance;DNA Methylation;DNA sequencing;Embryo;embryo quality;embryo tissue;embryo/fetus;Embryonic and Fetal Development;Embryonic Development;Environmental Risk Factor;Epigenetic Process;Ethics;Event;Exhibits;experience;Exposure to;Fat-Restricted Diet;Fatty acid glycerol esters;Female;Fertility;Fertilization;Fertilization failure;Fertilization in Vitro;fetal;Fetal Development;fetal programming;Fetal Tissues;Fetus;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Genomic Imprinting;Genomic Segment;Glucose Transporter;Grant;Growth Factor;Health;Human;Impairment;implantation;improved;in utero;Incidence;Individual;Infertility;infertility treatment;insight;Insulin Resistance;Kidney;Life;lifestyle intervention;Link;Liver;Longitudinal Studies;Macaca;Macaca mulatta;male;Mammals;Maternal Mortality;maternal obesity;Mediating;Metabolic;Metabolic dysfunction;Metabolism;Methylation;methylation pattern;Modeling;Modification;Molecular;mother nutrition;Mothers;nonhuman primate;obese patients;Obesity;obesogenic;offspring;oocyte maturation;Oocytes;Outcome;Ovarian Stimulations;Overweight;Phenotype;Placenta;Placental Infarction;Placentation;Pre-Eclampsia;Pre-implantation Embryo Development;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;preimplantation;Premature Birth;Primates;Process;Recommendation;Reporting;Reproduction;reproductive;reproductive function;Reproductive Process;Research Design;response;Rhesus;Risk Factors;RNA;Role;Sampling;sex;Signal Transduction;sperm cell;Spleen;Thymus Gland;Time;time-to-pregnancy;Tissues;transcriptome sequencing;Umbilical Cord Blood;Villous;Weight Gain;western diet;whole genome;Woman;Women's cohort;Work

PROJECT_TITLE: Maternal obesogenic diet-induced changes in embryo and fetal DNA methylation programming

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Bone fractures in the elderly are a major public health issue due to their high morbidity, mortality and healthcare costs, which need new therapy. Aging is often associated with cellular senescence, a stage when cell stopping growth and producing harmful factors to the body. We found a sub-group of senescent cells that are detrimental to fracture healing in aged mice. In this application, we will investigate how these detrimental senescent cells work and if specific removal of detrimental senescent cells can be a new treatment for old patients suffering from bone fracture.

PI_NAMEs: XING, LIANPING ;ZHANG, HENGWEI  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Affect;age related;age-related disease;aged;Aging;aging related disease;Anatomy;antagonist;Antioxidants;bone;Bone callus;Bone Diseases;bone fracture repair;Bone Marrow;cell age;Cell Aging;Cell Count;cell growth;Cells;Conditioned Culture Media;CXCL5 gene;Dasatinib;Data;Death Rate;DNA Damage;Elderly;Excision;Fracture;gain of function;Generations;Genetic Transcription;Growth;Health;Health Care Costs;Heterogeneity;IL8RB gene;Impairment;inhibitor;Intervention;intravital microscopy;Ligands;Light;Location;loss of function;Mesenchymal;Mesenchymal Stem Cells;Microscopy;Molecular;Morbidity - disease rate;mortality;multicatalytic endopeptidase complex;Mus;Names;new therapeutic target;novel therapeutics;old mice;older patient;Osteoporosis;PECAM1 gene;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphorylation Inhibition;Play;prevent;Proteins;Proteomics;PTPRC gene;Public Health;Quercetin;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Reporter;Reporting;Role;senescent cell;senolytics;Signal Induction;Signal Transduction;single-cell RNA sequencing;stem cell growth;Subgroup;System;Technology;Time;Tissue Inhibitor of Metalloproteinase-1;Tissue Inhibitor of Metalloproteinases;Transforming Growth Factor beta;Tyrosine Phosphorylation;Ubiquitin;Ubiquitination;Work

PROJECT_TITLE: Cell senescence in aging fracture

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Public Health Significance: Excessive alcohol consumption is the third-leading preventable cause of death in the United States. A promising alcohol use biomarker is increasingly being used as a laboratory test biomarker of recent alcohol use in forensic or legal or family court matters. The proposed study will improve upon the clinical utility of this alcohol use biomarker to better identify problematic drinking and lay the foundation for future work identifying the appropriate application of alcohol-use biomarkers in prevention and treatment programs.

PI_NAMEs: DOUGHERTY, DONALD M;HILL-KAPTURCZAK, NATHALIE  (contact);LIANG, YUANYUAN

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acute;Adopted;Alcohol consumption;alcohol free;alcohol measurement;Alcoholic beverage heavy drinker;Alcohols;Algorithms;Award;Biological;Biological Markers;Blood;Blood alcohol level measurement;Blood specimen;Body mass index;Body Weight;Cause of Death;Clinical;Communities;Consumption;court;Data;Dose;drinking;Drug Kinetics;enzyme activity;Enzymes;Equation;Exhibits;experimental study;Family;Forensic Medicine;Foundations;Funding;Future;Goals;Half-Life;Heavy Drinking;Homologous Gene;Hour;Human;improved;in vivo;Individual Differences;International;Laboratories;Laboratory Finding;Laboratory Study;Lead;Legal;Light;Measurement;Measures;Modeling;Observational Study;Participant;Patient Self-Report;Persons;Phase;phosphatidylethanol;Prevention program;Probability;Public Health;Red Blood Cell Count;Sampling;sex;Sex Differences;Source;Testing;treatment program;United States;Work

PROJECT_TITLE: Phosphatidylethanol and Other Ethanol Consumption Markers

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PHR: Project Narrative Upon successful completion of our aims, we expect our contributions will provide a novel tool for accurate long- term breast cancer risk assessment among Black women, extensive multi-site validation data and a complementary deployment/dissemination framework to enable further evaluations in research settings. Given that current long-term breast cancer risk models have limited applicability and/or low accuracy among Black women, our novel engineering approach to breast cancer risk assessment meets a critical need and, has the potential to advance personalized risk assessment for Black women. This, in turn, will reduce the number of breast cancers that are diagnosed at a later and more aggressive stage among Black women.

PI_NAMEs: GASTOUNIOTI, AIMILIA  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Adipose tissue;advanced breast cancer;Age;Artificial Intelligence;Attention;Benefits and Risks;Biostatistical Methods;Black Populations;black women;Body mass index;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;Breast Cancer Epidemiology;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Factor;breast density;breast imaging;cancer subtypes;Clinical;clinical practice;clinical risk;clinical translation;cohort;Communities;Data;Data Set;Database Management Systems;deep learning;deep learning model;design;Development;Digital Breast Tomosynthesis;Digital Mammography;digital models;Disparity;effective therapy;Engineering;Equity;European;Evaluation;experience;Family history of;Feedback;follow-up;Foundations;Goals;high body mass index;high risk;Hybrids;Image;imaging informatics;informatics tool;innovation;Interdisciplinary Study;Knowledge;Malignant Breast Neoplasm;Mammographic screening;Mammography;Medical Imaging;Menopausal Status;Modeling;Molecular;mortality;novel;open data;Outcome;parity;Pennsylvania;Performance;personalized screening;personalized strategies;Play;Population;Positioning Attribute;predictive tools;Predictive Value;Prevention strategy;preventive intervention;racial disparity;Radiology Specialty;Reporting;Research;Resources;Risk;Risk Assessment;Risk Factors;Sampling;Scheme;screening;Site;Study models;tool;United States;United States National Institutes of Health;Universities;Validation;Washington;White Women;Woman;Women's Health

PROJECT_TITLE: Advancing breast cancer risk assessment for Black women

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Shear stress is a blood flow-associated frictional force that regulates many vascular functions such as inflammation response, vascular permeability, and leukocyte adhesion, all of which are key factors in atherosclerosis. Both clinical and basic data demonstrate that failure in the clearance of dying cells from the body (defective efferocytosis) is linked to atherosclerosis-related events. How blood flow patterns affect efferocytosis in endothelial cells, the cells that line arteries, is largely unknown. Upon conclusion of this study, we will understand the role of blood flow patterns-related defective efferocytosis in endothelial cells, and this discovery will stimulate a new avenue in the design of drugs that treat atherosclerosis by enhancing efferocytosis in endothelial cells or introducing helical flow.

PI_NAMEs: DING, ZUFENG  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acute;Address;Adhesions;Affect;Aorta;aortic arch;Apoptotic;Area;Arterial Fatty Streak;Arteries;ascending aorta;Atherosclerosis;Binding;Blood;Blood Circulation;Blood flow;Blood Vessels;Cardiovascular system;Cell Line;Cells;Cessation of life;Chemicals;Chronic;Clinical;Coagulation Process;Common Femoral Artery;Common iliac artery structure;Complex;conditional knockout;Coronary artery;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Dendritic Cells;Descending aorta;Development;Diet;Disease;Drug Design;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;Epithelial Cells;Event;Exposure to;Failure;Fibrin;Fibroblasts;Flow Cytometry;Friction;Functional disorder;gain of function;Geometry;Goals;Growth;hemodynamics;High Fat Diet;Human;Impairment;In Vitro;Inflammation;innovation;Knock-out;Leukocytes;Ligation;Link;Lipids;loss of function;Low Density Lipoprotein Receptor;LoxP-flanked allele;Macrophage;mechanical stimulus;Mechanics;mechanotransduction;Mediating;member;Mesenchymal;Modeling;mouse model;Mus;Myocardial Ischemia;NADPH Oxidase;Necrosis;neutrophil cytosol factor 40K;neutrophil cytosol factor 67K;novel;novel therapeutic intervention;oxygen transport;Pathogenesis;Pattern;Phagocytes;Phenotype;Physiological;Plasmids;Play;prevent;Prevention;Process;Production;Protein S;receptor;Regulation;Research;response;Role;Rotation;Rupture;sensor;shear stress;single-cell RNA sequencing;Stroke;Stromal Cells;Surface;Testing;thrombotic;Tissues;Transfection;treatment strategy;Vascular Diseases;Vascular Endothelial Cell;Vascular Permeabilities;Western Blotting

PROJECT_TITLE: Impact of hemodynamics on efferocytosis in endothelial cells

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]