ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Overdose of the commonly used analgesic drug acetaminophen is a leading cause of liver toxicity and liver failure, in part because there have been no major advances in specific treatments to prevent progression of hepatotoxicity to acute liver failure. Acute liver injury is associated with activation of a blood clot degrading enzyme called plasmin, and prior studies suggest plasmin promotes blood vessel damage in the liver that causes acute liver failure and its most severe consequences. The primary goal of this research program is to uncover how plasmin activity is controlled in the injured liver, such that new therapies can be designed to prevent morbidity and mortality in patients with liver toxicity.

PI_NAMEs: COPPLE, BRYAN L;LUYENDYK, JAMES P (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;Acetylcysteine;Active Sites;Acute Liver Failure;acute liver injury;Agonist;Analgesics;Angiostatins;Anti-Inflammatory Agents;Automobile Driving;axl receptor tyrosine kinase;Biochemistry;Biological Markers;Blood coagulation;Blood Vessels;Breeding;Cell Separation;cell type;Cells;Complement;Cytolysis;Data;design;Dose;drug induced liver injury;Elastases;Enzyme Precursors;Enzymes;Equation;experimental study;extracellular;Failure;Fibrinolysis;Flow Cytometry;Gene Modified;Generations;genetic approach;Goals;Hemorrhage;Hepatic;Hepatocyte;hepatoprotective;Hepatotoxicity;hepatotoxin;Hospital Costs;Human;improved outcome;inhibitor;intrahepatic;knock-down;Knockout Mice;Leukocytes;Life;Link;lipid nanoparticle;Liver;Liver diseases;Liver Dysfunction;Liver Failure;liver injury;liver repair;Macrophage;Maps;Mediating;MME gene;Modality;Molecular;Morbidity - disease rate;mortality;Mus;Mutation;Nature;novel;novel therapeutics;Outcome;Overdose;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Plasma;Plasmin;Plasminogen;prevent;Prevention;Production;programs;protective effect;Proteins;Proteolysis;Proteomics;Publishing;Recommendation;Recovery;Regulation;Research;response;Risk;Role;Serine Protease;Signal Pathway;Site;Small Interfering RNA;System;Testing;Text;Therapeutic;thrombolysis;Time;United States;Update;Validation;Vascular Diseases;vascular injury

PROJECT_TITLE: Novel proteolytic mechanisms driving pathologic hepatic congestion in drug-induced hepatotoxicity

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: As there is continuing need to develop drugs to treat diseases, we are faced with training new scientists who understand the mechanism of these diseases, how to discover and characterize drug targets, how the drugs work and are processed by the body, and how to increase effectiveness and reduce adverse effects of the drugs. The collaboration of scientists from diverse backgrounds enhances creativity and innovation by bringing together a wide range of perspectives. Our program aims to 1) provide rigorous training that prepares PhD students to become leaders in the broad area of pharmacology and therapeutics; and 2) increase the diversity and quality of the national work force in this area.

PI_NAMEs: LAWLER, SEAN EDWARD;OANCEA, ELENA  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Interdisciplinary training in pharmacological sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The only way to significantly increase the participation to large-scale genomic studies to further biomedical research and human health is to protect patient privacy. The ability to accomplish this is dependent upon developing computational techniques that quantifies the privacy risk and provides alternative ways to share the data while maximizing the utility. The proposed research combines novel statistical and molecular biology techniques to 1) quantify the amount of private information leakage in genomic summary results, and 2) develop tools to asses risk of privacy and means to share data while balancing usability and privacy.

PI_NAMEs: GURSOY, GAMZE  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Assessment tool;Binding;Biochemistry;Biomedical Research;Biophysics;Blood;cohort;Computational Technique;Consent;Coupled;cryptography;Data;Data Science;Data Set;data sharing;Databases;Democracy;design;Detection;Disease;DNA;experimental study;Extravasation;functional genomics;Future;Gene Frequency;Genetic;genetic testing;Genome;genome sequencing;genomic data;Genomics;Genotype;Glass;Goals;Health;Human;improved;Individual;Information Theory;laboratory experiment;Learning;Life;Link;Masks;Measures;Medical Research;Mentorship;Mining;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;nanopore;Noise;non-traditional data;novel;Participant;patient privacy;Patients;personalized medicine;Phase;Phenotype;point of care;Policies;Population;portability;Privacy;Privatization;Protocols documentation;Research;Research Personnel;Risk;Risk Assessment;risk prediction;Sample Size;Sampling;simulation;Single Nucleotide Polymorphism;Source;Stigmatization;success;Swab;Techniques;Technology;Testing;tool;Touch sensation;Training;United States National Institutes of Health;Universities;usability;Work

PROJECT_TITLE: Realistic quantification of potential privacy loss from genomic summary results

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Chronic diseases associated with physical inactivity, sedentary behaviors, and poor diet and are the silent killers of the modern era for American Indian communities. Better information is needed on multilevel, outdoor-based, culturally grounded, and sustainable physical activity and healthful diet interventions for Native youth.

PI_NAMEs: JOHNSON-JENNINGS, MICHELLE D (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;active lifestyle;Address;Adolescence;Adolescent;Adult;Age;alcohol tobacco and other drug use;Alcohols;American Indian community;American Indian Population;American Indian Tribe;American Indians;Area;behavior change;Behavioral;behavioral health;Body mass index;built environment;burden of chronic illness;Cardiovascular Diseases;Cessation of life;Choctaw;Choctaw Nation of Oklahoma;Chronic;Chronic Disease;Communities;community organizations;Consumption;control trial;Country;County;Coupled;Data;design;Deterioration;Development;Diabetes Mellitus;Diet;Dietary Intervention;Diffusion;Disparity;Environment;Environmental Health;Epidemic;epidemiologic data;Event;experience;Focus Groups;Food;food desert;Food Habits;Green space;Harvest;Health;health disparity;illicit drug use;Immersion;improved;indexing;Individual;innovation;Intervention;intervention effect;Intervention Studies;Interview;Leadership;leadership development;Life Style;Maps;Mediating;Modeling;Modernization;Morbidity - disease rate;Motivation;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Native Americans;native youth;Nature;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;obesity prevention;Oklahoma;Participant;Pathway interactions;Pattern;Physical activity;physical inactivity;poor health outcome;Population;Poverty;premature;Premature Mortality;preservation;Prevalence;primary outcome;programs;prospective;Qualitative Methods;Randomized;Research;response;Risk;Risk Factors;Role;secondary outcome;sedentary lifestyle;skills;sociodemographics;stem;Substance abuse problem;success;Testing;Time;Tobacco;Trauma;trial design;tribal community;tribal leader;Tribes;Unhealthy Diet;United States Department of Agriculture;visual map;Waiting Lists;Walking;Weight;Woman;Work;Youth

PROJECT_TITLE: Wakaya: Rising Up for Choctaw Youth Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The project assembles leading cavernous angioma researchers with the aim of developing blood tests for the diagnosis and prediction of symptomatic brain hemorrhage, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.

PI_NAMEs: AWAD, ISSAM A (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: accurate diagnosis;Affect;Age;Algorithms;American;angiogenesis;Anticoagulants;Automobile Driving;Behavior;Benchmarking;Benign;Biological Markers;biomarker development;biomarker discovery;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood Tests;Blood Vessels;Brain hemorrhage;Brain Pathology;candidate marker;Cavernous Hemangioma;Cerebrovascular Disorders;Cerebrum;Characteristics;Clinical;clinical application;Clinical Management;Clinical Trials;clinically relevant;cohort;Collaborations;Complement;Complex;Computational Biology;contrast enhanced;Cross-Sectional Studies;Data;Data Element;data harmonization;Deposition;Diagnosis;Diagnostic Sensitivity;Diagnostic Specificity;diagnostic value;Discriminant Analysis;Disease;disorder subtype;Enrollment;Exhibits;follow-up;Future;Genetic;Genotype;Goals;gut microbiome;Hemorrhage;high risk;IL6 gene;Image;imaging biomarker;Immune;indexing;Individual;Inflammation;Inflammatory;Interleukin-1 beta;Iron;Knowledge;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;Mediating;microbiome;Modeling;Monitor;Natural Immunity;Nervous System Disorder;neurovascular unit;novel;novel marker;Patients;Perfusion;Peripheral;peripheral blood;Pilot Projects;Plasma;Plasma Proteins;Population;Predisposition;premature;Process;Prognosis;prognostic;prognostic value;prognostication;Proteins;recruit;Research;Research Personnel;Risk;RNA;Sampling;Seizures;Sensitivity and Specificity;sex;Signal Transduction;Site;statistics;Subgroup;supervised learning;support vector machine;synergism;Techniques;Testing;therapeutic development;Time;transcriptome;treatment response;trial readiness;Uncertainty;Validation;Variant;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vitamin D Deficiency

PROJECT_TITLE: Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: PHYSIOLOGY

PHR: NARRATIVE Heart disease is the leading cause of death in the United States and worldwide. This proposal seeks to understand how key proteins in the heart normally function, and how their altered behavior contributes to heart disease. The results will increase our understanding of molecular mechanisms of heart disease, and lay the foundation for the development of effective new treatments.

PI_NAMEs: COLECRAFT, HENRY M. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Aging;Animal Model;Behavior;Calcium;Calcium Channel;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cells;Chronic stress;cohort;Collaborations;combat;Complex;Consanguinity;Coupling;Data;Development;Disease;Disease Progression;Dissection;DNA Sequence Alteration;effective therapy;experimental study;fighting;foot;Foundations;Functional disorder;genetic regulatory protein;genome resource;Genotype;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Human;Individual;innovation;insight;Knock-out;Knowledge;Link;loss of function mutation;Mediating;Missense Mutation;Molecular;Mus;Mutation;Myocardial dysfunction;Myocardium;nanobodies;nanoengineering;new therapeutic target;novel therapeutics;Pakistan;Pathology;Pathway interactions;Phenotype;phenotypic data;Physiological;Physiology;Population;Post-Translational Protein Processing;Prevalence;prevent;Program Research Project Grants;Proteins;receptor function;Recording of previous events;Regulation;Regulatory Pathway;Research;response;Role;Ryanodine Receptor Calcium Release Channel;Signal Transduction;single molecule;Stress;structural biology;Structure;Surface;therapeutic target;tool;trafficking;United States;Variant

PROJECT_TITLE: Structure-Function of Calcium Channel Complexes in Cardiac Physiology and Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Physical Activity;Prevention

PI_NAMEs: SALEHEEN, DANISH  (contact)

PROJECT_TERMS: Adult;Alleles;Anthropometry;biobank;Biochemical;Biological;Biological Assay;Biological Markers;Birth;Calcium Channel;Callback;Cardiac;Cardiovascular system;Characteristics;clinical examination;Complex;consanguineous family;Consanguinity;Diet;Disease;Disease Outcome;Echocardiography;Electrocardiogram;Embryo;Exercise stress test;exome;exome sequencing;experimental study;Family member;gain of function;gene function;General Population;Genes;Genetic;Genetic Engineering;Genetic Variation;genome resource;genome sequencing;genome wide association study;genomic data;Genotype;Glycosylated hemoglobin A;Heart;Heart Diseases;Heart failure;Heterozygote;Homozygote;Human;Human Biology;Human Genetics;Image;in vivo;in vivo Model;Individual;insight;Knock-out;large datasets;large scale data;Life;Life Style;Lipids;loss of function;loss of function mutation;Mediating;Medical History;Metabolic;metabolomics;Missense Mutation;Monitor;mutant;Mutation;Myocardial Infarction;new therapeutic target;novel;offspring;Outcome;Pakistan;Participant;Pathway interactions;Persons;Phenotype;Physical activity;Physiology;pleiotropism;population based;proband;programs;protein function;Protein Truncation;recruit;Resources;reverse genetics;Risk Factors;RNA Splicing;Services;Single base substitution;Site;Stroke;Structure;Tobacco use;trait;Variant;whole genome

PROJECT_TITLE: Human Genetics and Phenotyping Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The proposed continuation of a recently-funded T32 Translational Addiction Research Fellowship at the University of Pennsylvania will give 4 pre-doctoral and 4 post-doctoral trainees the framework, and the skills, to speed the next generation of effective addiction treatments – with concomitant benefit for the addiction-linked public health problems of violence, crime and HIV/AIDs.

PI_NAMEs: BLENDY, JULIE A;CHILDRESS, ANNA ROSE (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Fellowship Program;Research

PROJECT_TITLE: T32 Translational Addiction Research Fellowship Program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  Students who complete this predoctoral training program will have acquired basic knowledge of pharmacology and related fields, in-depth knowledge of an important area of biomedical research, skill in planning and executing a valuable, rigorous research project in the pharmacological sciences, and exceptional ability to analyze, interpret and communicate results. These skills provide a sound basis for scientific careers in academia, government, or industry.

PI_NAMEs: CALABRESE, JOSEPH MAURO;EMANUELE, MICHAEL JAMES (contact)

PROJECT_TITLE: Predoctoral Training in the Pharmacological Sciences

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Pediatric physician-scientists play a vital role in advancing knowledge related to child health. There remains a national need to stimulate child health research by enhancing the training of early-stage pediatric physician-scientists. This program supports the mentored career development of pediatric physician-scientists by optimally leveraging the resources of the Washington University School of Medicine as we have done for the past 20 years.

PI_NAMEs: SILVERMAN, GARY ARTHUR (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Childhood;Physicians;Scientist;Training

PROJECT_TITLE: Training of the Pediatric Physician-Scientist


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PI_NAMEs: TSAI, EMILY J (contact)

PROJECT_TERMS: Acceleration;aorta constriction;Calcium Channel;Calcium Signaling;Cardiac;Cardiac health;Cardiac Myocytes;Catheters;Chronic;clinically relevant;Complex;Congestive Heart Failure;Coronary artery;Coupling;Disease;Echocardiography;Equipment;gene function;Gene Modified;genetic variant;genome resource;Genotype;Glean;Health;Heart Diseases;Heart failure;Human;Human Resources;In Vitro;in vivo;Individual;innovative technologies;insight;Ischemia;ischemic injury;L-Type Calcium Channels;Left;Left ventricular structure;Ligation;loss of function;Macromolecular Complexes;macromolecule;Measurement;Measures;Microsurgery;mouse model;multidisciplinary;Mus;Myocardial Ischemia;novel therapeutics;Operative Surgical Procedures;Pathologic;Phenotype;Physiologic intraventricular pressure;Physiological;Physiology;pressure;Principal Investigator;Procedures;Program Research Project Grants;programs;Regulation;Research Personnel;Resolution;response;Ryanodine Receptor Calcium Release Channel;Signal Transduction;Standardization;Stress;Structure;Structure-Activity Relationship;synergism;Technical Expertise;Testing;therapeutic development;Therapeutic Intervention;Time;Transgenic Mice;Variant;Work

PROJECT_TITLE: Mouse Cardiac Physiology Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PUBLIC HEALTH RELEVANCE: Non-alcoholic steatohepatitis (NASH) has been a major health problem worldwide without effective treatment or preventive measures. Our proposed study will investigate the regulation and function of ChREBPα as a protective factor in diet-induced NASH by preserving hepatic fatty acid oxidation and suppressing the activation of hepatic stellate cells and fibrosis. The study has great potential in uncovering new therapeutic avenues for treating NASH.

PI_NAMEs: YIN, LEI  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Acute;Affect;Agonist;American;Animals;Arachidonic Acids;Binding Proteins;Biochemical Pathway;Carbohydrates;Cells;Cessation of life;Cholesterol;Chronic;chronic liver disease;Cirrhosis;Complex;Cultured Cells;Data;Degradation Pathway;Development;Diet;Disease;Down-Regulation;drug development;effective therapy;Event;experimental study;fatty acid oxidation;Fatty Liver;fatty liver disease;feeding;fibrogenesis;Fibrosis;Fructose;Future;General Population;Genetic Transcription;Health;Hepatic;Hepatic Fibrogenesis;Hepatic Stellate Cell;Hepatocyte;Human;Impairment;In Vitro;Inflammation;Injury;JNK-activating protein kinase;Knockout Mice;Knowledge;Link;Lipids;Liver;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Malignant neoplasm of liver;MAPK8 gene;Mediating;Metabolism;Molecular;Mus;mutant;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;novel therapeutics;Nutritional;overexpression;Pathologic;Pathway interactions;patient population;Patients;Pharmacological Treatment;Phosphorylation;Post-Translational Protein Processing;preservation;prevent;Prevention strategy;Preventive measure;protective factors;protective pathway;Protein Isoforms;Proteins;public health relevance;reconstitution;Regulation;Response Elements;Ring Finger Domain;Risk Factors;Role;saturated fat;Signal Pathway;simple steatosis;Source;Stress;Testing;THBS1 gene;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;ubiquitin-protein ligase;Ubiquitination;Up-Regulation

PROJECT_TITLE: Significance and mechanisms of hepatic ChREBPα induction via post-translational modifications in diet-induced NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: EUGENE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative As providing care comes at great physical and psychosocial cost for both persons with ADRD and their caregivers, reducing sources of caregiver burden is a clear health priority. Dysphagia (swallowing impairment) is a highly prevalent consequence of ADRD and strong contributor to morbidity and mortality; this proposed study seeks to address the clear gap in our current understanding of dysphagia’s contributions to burden among caregivers of persons with ADRD. The results of this study will directly inform the development of a new, evidence-based intervention for reducing aspects of caregiver burden related to dysphagia management in ADRD and thus offer a unique opportunity to proactively intervene with families earlier, ameliorating, and potentially even preventing, the development of aspects of burden over time.

PI_NAMEs: SHUNE, SAMANTHA EVE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Alzheimer's disease related dementia;Assessment tool;Behavior;care burden;care recipients;Caregiver Burden;Caregiver support;Caregivers;caregiving;Caring;clinical practice;Competence;cost;Data;Deglutition;Deglutition Disorders;Dementia;dementia care;Dependence;Development;Diagnosis;Diet;Diet Modification;Dimensions;Disease;Eating;Education;effective intervention;Emotional;Ensure;Equipment and supply inventories;Evidence based intervention;experience;Family;Family Caregiver;Foundations;Future;global deterioration scale;Goals;Health;Health Priorities;Health Promotion;High Prevalence;Impaired cognition;Impairment;improved;International;Intervention;Knowledge;Measures;Modeling;Morbidity - disease rate;mortality;novel;older adult;Older Population;Patient Self-Report;Persons;Phase;prevent;psychosocial;Quality of life;Readiness;Recommendation;recruit;Reporting;Research;research study;Role;Safety;screening;Severities;Severity of illness;Social support;Source;Specificity;standard of care;Standardization;Surveys;Testing;therapy design;Time;Work

PROJECT_TITLE: Influence of swallowing impairment on burden among caregivers of persons with Alzheimer's Disease and related dementias

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) remains a major public health issue, as one-third of Americans are unscreened; this study aims to improve CRC screening uptake by developing and validating the Automated Colorectal Cancer Educational Support System (ACCESS) – an online, immersive, and interactive conjoint analysis-based decision aid that supports patients in selecting a CRC screening modality congruent with their preferences and values. Development of ACCESS will: (1) be informed by foundational research using qualitative research and conjoint analysis methodologies that will gain insights into patients’ knowledge, attitudes, beliefs, and drivers of decision making regarding the different CRC screening test options; and (2) be built in partnership with patients, clinicians, implementation scientists, user interface and experience experts, and computer scientists. It will be validated through a pilot randomized controlled trial that tests whether provision of the ACCESS decision tool, through optimizing shared decision making and improving the patient-clinician interaction, leads to selection of a screening modality that accurately maps to a patient’s values, and as a result, increases acceptance and completion of CRC screening.

PI_NAMEs: ALMARIO, CHRISTOPHER V (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Academy;Acceleration;Address;Adopted;Adoption;Advisory Committees;Age;Aging;American;Area;Attitude;Award;Behavioral;Behavioral Sciences;Belief;cancer education;cancer prevention;Clinic;Clinic Visits;Clinical;clinical practice;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Communication;Competence;Complex;computer science;computer scientist;cost;Decision Aid;Decision Making;Decision Support Systems;design;Development;digital;digital health;Disadvantaged;Educational workshop;Electronic Health Record;Endoscopy;evidence base;experience;Extramural Activities;Feces;Foundations;Funding;Future;Gastroenterologist;Gastroenterology;Goals;Grant;Health Promotion;Health Sciences;Health Services;Healthcare;Image;implementation science;improved;Individual;innovation;insight;Intervention;Knowledge;Learning;Literature;Malignant Neoplasms;Maps;Measurement;Media Campaign;Medicine;Mentorship;Methodology;Modality;Modeling;Modernization;natives;novel;Oncology;Online Systems;Outcome;Paper;patient health information;patient navigation;patient portal;Patient Preferences;Patient-Centered Care;Patients;Physicians;preference;Preventive care;Preventive service;Primary Care Physician;Principal Investigator;Process;programs;Provider;Public Health;Qualitative Research;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Personnel;Risk;Scientist;screening;Screening for cancer;screening guidelines;shared decision making;Statutes and Laws;Support System;Surveys;Techniques;Technology;Testing;tool;treatment as usual;trial design;United States National Institutes of Health;United States Preventative Services Task Force;uptake;Validation;web based decision aid;Work;Writing

PROJECT_TITLE: Automated Colorectal Cancer Educational Support System (ACCESS): Development and Validation of a Novel Online Decision Aid for Improving Colorectal Cancer Screening Uptake

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Immunization;Prevention

PROJECT_TERMS: Action Potentials;Affect;Aging;aorta constriction;Applications Grants;Biological Assay;Calcium Channel;Callback;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiovascular effects;Catalogs;Cause of Death;Cells;Cessation of life;Chimeric Proteins;Chronic stress;combat;Complex;Confocal Microscopy;Consanguinity;Coronary artery;Coupling;Cyclic AMP-Dependent Protein Kinases;Data;Data Analyses;Deubiquitination;Dihydropyridines;Disease;DNA Sequence Alteration;druggable target;Echocardiography;Electrophysiology (science);Epitopes;extracellular;Flow Cytometry;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;forging;Functional disorder;Genes;genome resource;genomic data;Heart;heart cell;Heart Diseases;Heart failure;heart function;Heterogeneity;Heterozygote;Human;Immunization;in vivo;Individual;insight;Knock-in Mouse;Label;Left;Libraries;Ligation;Literature;Llama;loss of function;loss of function mutation;Macromolecular Complexes;Methods;Missense Mutation;Molecular;Molecular Probes;Mus;mutant;Mutation;Myocardial Infarction;nano;nanobodies;nanoengineering;new therapeutic target;novel;novel therapeutics;null mutation;Optics;Pakistan;patch clamp;Pathway interactions;Persons;Phage Display;Phenotype;phenotypic data;Physiologic pulse;Physiology;Population;Prevalence;prevent;Process;Program Research Project Grants;prospective;protein purification;Proteins;Proteomics;reconstitution;Regulation;Resistance;Resources;Signal Transduction;Site-Directed Mutagenesis;Structure;tool;trafficking;Transgenic Mice;trend;Ubiquitination;United States;Visualization

PROJECT_TITLE: Novel Tools to Probe Trafficking and Function of Calcium Channel Signaling Complexes in Heart


NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Rare Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE The environment of lung tumors is hostile requiring tumors to adapt to be able to survive and grow. Part of this adaptation is a change in metabolism and increases the antioxidant, glutathione to combat the augmented oxidative stress. In this proposal we will address the mechanism whereby this increase in glutathione occurs and offer new strategies to prevent the increases in glutathione from happening. We will test whether this strategy can be used to augment the therapeutic efficacy of the chemotherapeutic drug, cisplatin.

PI_NAMEs: JANSSEN-HEININGER, YVONNE M. W. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Ablation;Address;Adenoviruses;Amino Acids;Antioxidants;antiporter;Attenuated;Binding;Biochemistry;Breeding;Cessation of life;Cisplatin;Clinical;combat;Cysteine;Cystine;Dependovirus;Development;Enterobacteria phage P1 Cre recombinase;Environment;Glutamates;glutaredoxin;glutaredoxin 2;Glutathione;Glutathione Metabolism Pathway;Growth;Homeostasis;Human;human subject;Immune checkpoint inhibitor;In Vitro;insight;KRAS2 gene;KRASG12D;Link;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mus;mutant;NADP;neoplastic cell;novel therapeutic intervention;Oncogenic;Organoids;ovarian neoplasm;Oxidants;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathway interactions;penicillamine-glutathione mixed disulfide;Pharmaceutical Preparations;Pharmacologic Substance;preclinical development;prevent;Property;Protein S;Proteins;Proteomics;Refractory;Regimen;Resistance;Role;side effect;Signal Transduction;standard of care;Structure;Sulfhydryl Compounds;System;Testing;Therapeutic;Time;Tissues;Treatment Efficacy;tumor;Tumor Burden;tumor growth;tumorigenesis;tumorigenic;ubiquitin isopeptidase;Ubiquitination;Xenograft procedure

PROJECT_TITLE: Glutaredoxin, Glutathione Metabolism and Lung Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: ROCKVILLE

ORG_NAME: ABVACC, INC.

ORG_STATE: MD

PHR: Staphylococcus aureus (SA), in particular methicillin-resistant SA (MRSA) is a major human pathogen causing significant mortality and morbidity in the US and around the world. There is no vaccine available for this pathogen. The majority of MRSA infections are skin and soft tissue infection (SSTI). SSTI is a major cause of morbidity with over 11 million doctor visits per year in the US. It is also a breading ground for increasing antimicrobial resistance. We are developing a multivalent toxoid vaccine against SA SSTI. In this project we intend to perform a set of immunological studies in patients to determine the markers of immune protection in humans and evaluate the feasibility of a toxoid vaccine. Furthermore, studies in mouse models are proposed to evaluate the mechanism by which toxins modulate the immune response to SA. Our studies will be critically important for future clinical trials for development of vaccines for SA-SSTI.

PI_NAMEs: AMAN, M JAVAD (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Accident and Emergency department;Active Immunization;Acute;Address;Adult;Advanced Development;Animal Model;anti-toxin;Antibiotic Resistance;Antibodies;Antibody titer measurement;Antigens;Antimicrobial Resistance;arm;Bacteremia;Biological;Biometry;Bread;Breeding;capsule;Cardiovascular Surgical Procedures;Cells;Chills;Clinical;clinical development;Clinical Research;Clinical Trials;cost;cytokine;Cytotoxic T-Lymphocytes;Development;Disease;efficacy evaluation;efficacy trial;Epidemiology;epidemiology study;experience;Failure;Funding;Future;Genus staphylococcus;Gram-Positive Bacteria;Grant;Heart;Human;human pathogen;humanized mouse;IL17 gene;Immune;Immune response;Immunologic Markers;Immunologics;Immunologist;Immunology;immunoregulation;improved;Incidence;indexing;Industry;Infection;Infectious Skin Diseases;insight;Investments;Kinetics;Knowledge;Learning;Life;manufacture;Marketing;methicillin resistant Staphylococcus aureus;Methodology;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Nature;neutralizing antibody;novel;Olives - dietary;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Passive Immunization;pathogen;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Phase I Clinical Trials;phase I trial;Phase II/III Trial;Pneumonia;Polysaccharides;prevent;Primary Infection;Probability;prospective;Prosthesis;protective efficacy;Public Health;rational design;Recurrence;recurrent infection;Reporter;Reporting;research and development;response;Role;Sampling;Schedule;Sepsis;Severity of illness;Shapes;Site;skin disorder;Soft Tissue Infections;Source;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;success;Superantigens;Surface Antigens;T cell response;T-Lymphocyte;Target Populations;Testing;Time;Tissues;Toxic Shock Syndrome;Toxin;Toxoids;Transgenic Mice;vaccine access;Vaccine Antigen;vaccine candidate;vaccine development;vaccine efficacy;Vaccine Research;Vaccinee;Vaccines;Virulence Factors;Visit;γδ T cells

PROJECT_TITLE: Multivalent Toxoid Vaccine for recurrent Staphylococccus aureus disease

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The long-term goal of this research program is to gain a thorough and mechanistic understanding of the regulatory processes that control signaling by G protein-coupled receptors (GPCRs), which are the largest family of signaling receptors expressed in the human body and largest class of druggable targets. The proper regulation of GPCR signaling is critical for maintaining cellular homeostasis, dysregulation of these pathways, through either aberrant increases or decreases in signaling drives disease progression. An understanding of how GPCR signaling is regulated in normal cellular physiology and dysregulated in disease is critical for advancing the status of GPCRs as viable drug targets for future therapeutic development.

PI_NAMEs: TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adaptor Signaling Protein;Arrestins;Biological;Cell membrane;Cell Physiology;Cells;Development;Disease;Disease Progression;Drug Targeting;druggable target;Endosomes;Family;FDA approved;Funding;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Homeostasis;Human body;improved;innovation;Knowledge;Laboratories;Mediating;Mediator;Molecular;new therapeutic target;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pharmaceutical Preparations;Process;programs;Proteins;receptor function;Receptor Signaling;Regulation;Research;response;Signal Transduction;System;Technology;therapeutic development;trafficking;tumor progression;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;vascular inflammation;virtual

PROJECT_TITLE: Cell signaling by G protein-coupled receptors

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cancer;Nutrition;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: Narrative The proposed research aims to provide a better understanding of the mechanisms by which calorie restriction can impede ovarian cancer progression. Our study will show that calorie restriction can improve anti-tumor immunity by affecting the cellular metabolism of macrophages. This work is directly relevant to public health as the findings of this study will help guide the design of low-cost life-style interventions and precisely targeted therapies for ovarian and other cancers.

PI_NAMEs: RATTAN, RAMANDEEP  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Affect;anti-tumor immune response;Antitumor Response;Ascites;Caloric Restriction;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;cancer type;Cell Respiration;Cells;Cessation of life;chemotherapy;Citric Acid Cycle;cost;Data;design;Development;Diet;dietary;dietary approach;Dietary Intervention;dietary restriction;effective therapy;Energy Metabolism;Environment;Epithelial ovarian cancer;Equilibrium;Exhibits;Fatty acid glycerol esters;Financial Hardship;Glycolysis;Goals;Greater sac of peritoneum;Growth;Immune;Implant;improved;in vivo;Knockout Mice;Knowledge;Life Style;Life Style Modification;lifestyle intervention;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Malnutrition;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;mouse model;Mus;Neoplasm Metastasis;novel;Operative Surgical Procedures;Outcome;Ovarian;Pathogenesis;Pathway interactions;Patients;Peritoneal;Permeability;Phenotype;Platinum;Population;Process;Production;Prognosis;Public Health;Publishing;Quality of life;Regimen;Research;Resources;Respiration;response;side effect;Survival Rate;targeted treatment;taxane;Testing;Therapeutic;Transgenic Mice;Translating;translational impact;Tricarboxylic Acids;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenic;United States;Work

PROJECT_TITLE: Determining the mechanisms by which calorie restriction alters macrophage polarization to promote an anti-tumor environment in epithelial ovarian cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


PI_NAMEs: MARX, STEVEN O (contact)

PROJECT_TERMS: Ablation;Acute;Adrenergic Agents;Adrenergic Agonists;Adrenergic beta-Agonists;Adrenergic beta-Antagonists;Affinity;Alanine;Animals;aorta constriction;Arrhythmia;ascorbate;Attenuated;beta-adrenergic receptor;Binding;Biochemical;Biological Assay;Biological Markers;C-terminal;Calcium;Calcium Channel;Cardiac;Cardiac Myocytes;cellular targeting;cohort;Collaborations;Complex;Congestive Heart Failure;consanguineous family;Coronary artery;Cyclic AMP-Dependent Protein Kinases;Deletion Mutation;desensitization;Disease;Disinhibition;Echocardiography;Electrocardiogram;Electrophysiology (science);Enzymes;Exercise stress test;Exons;Exposure to;Fluorescence Resonance Energy Transfer;Forskolin;gain of function;Genetic;genome resource;Goals;Health;Heart;Heart Atrium;Heart Contractilities;Heart failure;heart function;Heart Rate;Heterozygote;Human;Human Inbreeding;Hypertrophy;In Vitro;Incidence;Individual;inducible gene expression;Inherited;inhibitor;insight;Isoproterenol;Knock-in Mouse;Label;Lead;Left;Ligation;loss of function;Mass Spectrum Analysis;Mechanics;Medical;Methods;Missense Mutation;Modeling;Molecular;Monitor;Monomeric GTP-Binding Proteins;mortality;Mus;mutant;Mutate;Mutation;Myocardial;Myocardial Degeneration;Myocardial dysfunction;N-terminal;Nervous System;novel;Outcome;overexpression;Pakistan;Participant;Pathologic;Peroxidases;Phenotype;Phosphorylation;Phosphorylation Site;Physiological;Physiology;premature;pressure;prevent;Probability;proband;Property;Protein Dephosphorylation;Proteins;Proteomics;rare variant;Regulation;Regulatory Pathway;Role;Sarcomeres;Serine;Serum;Signal Pathway;Signal Transduction;Site;Structure;Sympathetic Nervous System;symptom treatment;Syndrome;Testing;Transgenic Organisms;Ventricular;voltage

PROJECT_TITLE: Roles of Rad and other CaV1.2 neighboring proteins in regulating cardiac function in health and disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Enteroviruses are amongst the most common human infections worldwide. These viruses are primarily transmitted via the fecal-oral route, where they target the human gastrointestinal epithelium very early in their infectious life cycles. We propose studies to interrogate the mechanisms by which enteroviruses infect the human GI epithelium utilizing human and mouse models. These studies will provide fundamental insights into the mechanisms by which enteroviruses breach the GI barrier.

PI_NAMEs: COYNE, CAROLYN B (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Apoptotic;base;Cell Communication;Cell Line;Cell model;cell type;Cells;Cellular Structures;Complex;Coxsackie B Viruses;Coxsackie Viruses;Cues;Cultured Cells;Data;Disease;Echo Viruses;Enteral;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Environment;Epithelial Cells;Epithelium;Event;exosome;extracellular;Functional disorder;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression Profile;Goals;Growth;Human;human model;Human poliovirus;Immune response;Immune signaling;Immunocompetent;Immunologics;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Inflammatory;insight;Interferon Type II;Interferon-beta;Interferons;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Laboratories;Life Cycle Stages;microbial;Modeling;Molecular;mouse model;Mus;Nature;new therapeutic target;Nonlytic;novel;Oral;Organ;particle;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Physiological;Positioning Attribute;prevent;Property;Research;response;Role;Route;self-renewal;Signal Transduction;Specificity;stem cell differentiation;stem cell model;stem cells;Structure;Surface;System;Testing;therapeutically effective;Tissues;transmission process;Viral;Virus

PROJECT_TITLE: Enterovirus Infection of Polarized Intestinal Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Patients with sickle cell disease (SCD) are at risk for disease related cognitive deficits that contribute to academic failure and decreased vocational attainment. A critical gap exists in the development of feasible and acceptable evidence-based behavioral interventions to address the functional consequences of cognitive deficits in patients with SCD. This proposal will adapt and test a behavioral intervention for preschoolers with SCD and facilitate the development of future interventions with great potential for improving quality of life for all children living with SCD.

PI_NAMEs: HEITZER, ANDREW M (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Age;American Society of Hematology;Attention;Back;Behavior assessment;Behavior Therapy;Behavioral;behavioral clinical trial;biobehavior;Black Populations;Black race;career;career development;Career Mobility;Caregivers;Characteristics;Child;Child Development;Child Rearing;child services;Clinical Research;clinical training;Cognitive deficits;cognitive rehabilitation;cohort;Cohort Studies;Collaborations;comparison intervention;Consent;contextual factors;Data;design;Development;Development Plans;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;disorder risk;dissemination science;Doctor of Philosophy;Dropout;Early Intervention;Economics;Effectiveness;efficacy study;efficacy trial;evidence base;Evidence based intervention;experience;Failure;Family;foster care;Foundations;Functional disorder;Funding;Future;Genetic Diseases;Goals;Grant;Guidelines;help-seeking behavior;Hemoglobin;implementation science;improved;Individual;Inequity;Informal Social Control;Intervention;intervention mapping;intervention program;Intervention Trial;Interview;kindergarten;Learning Skill;Life;life span;literacy;Logic;Longitudinal cohort study;mathematical ability;Mathematics;Measures;Medical;member;Mentors;Mentorship;Methods;Modeling;Nature;Neurocognitive;Neurocognitive Deficit;Neurologic;Neuropsychology;Nursery Schools;Outcome;Patients;peer;Performance;Persons;pilot trial;Population;Population Intervention;post intervention;Poverty;Preschool Child;prevent;Problem Solving;programs;prospective;Psychology;Publications;Quality of life;racial minority;racism;Randomized;Randomized, Controlled Trials;Readiness;Reading;Records;recruit;rehabilitation strategy;Reporting;Research Methodology;Research Personnel;routine care;Saint Jude Children's Research Hospital;Schools;Science;Service provision;Short-Term Memory;Sickle Cell;Sickle Cell Anemia;Site;skills;social culture;social stigma;Socioeconomic Factors;Structure;Students;success;Target Populations;Testing;Training;Treatment Efficacy;underserved community;United States;United States National Institutes of Health;Vocation;Work;Writing

PROJECT_TITLE: School Readiness Intervention for Preschool Children with Sickle Cell Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: PROJECT NARRATIVE The dynamic nature of G protein-coupled receptors (GPCRs) enables these sensory proteins to recognize and bind a wide range of extracellular molecules with different shapes and chemical properties. We plan to directly visualize the dynamic behavior of GPCRs in real-time using single-molecule fluorescence microscopy, which reveals hidden structural characteristics that should provide new insights into GPCR functions in native-like environments. We initially apply this state-of-the-art microscopy technique to investigate the dynamic behavior of two human GPCRs: an adenosine receptor that regulates inflammation and a glucagon receptor that binds the main metabolic hormone in the human body.

PI_NAMEs: LAMICHHANE, RAJAN  (contact)

PROJECT_TERMS: ADORA2A gene;Affect;Behavior;Benchmarking;Binding;blood glucose regulation;Characteristics;chemical property;Chemical Structure;Complex;conformer;Cryoelectron Microscopy;design;diabetes mellitus therapy;Disease;Drug Targeting;Environment;extracellular;Extracellular Domain;FDA approved;Fluorescence;Fluorescence Microscopy;G-Protein-Coupled Receptors;Glucagon;Glucagon Receptor;Glucagon Receptor Binding;Goals;Hormones;Human;Human body;improved;Inflammation;insight;Investigation;Ligand Binding;Ligands;Lipids;Maps;Measurement;Membrane;Membrane Proteins;Metabolic hormone;Microscopy;Molecular Conformation;Mutation;Nature;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Proteins;Purinergic P1 Receptors;Receptor Activation;receptor function;Research Project Grants;response;Role;screening;Sensory;Sensory Receptors;Shapes;Signal Transduction;Signaling Protein;single molecule;small molecule;Structure;Techniques;Therapeutic;Time;time use;Transmembrane Domain;Visualization;X-Ray Crystallography

PROJECT_TITLE: Conformational Dynamics of G Protein-Coupled Receptors at the Single-Molecule Level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Graduate science education plays a critical role in the success of the U.S. workforce and economy, attracting and producing a diverse work force of researchers, innovators, educators, and leaders. We developed an innovative graduate program relying on the traditions and experience of one of the oldest pathology training programs in the country, but incorporating creative approaches to provide operational (cutting edge in-depth knowledge), technical (state-of-the-art methodology) and professional (transition into careers) skills that will lead to the output of true translational, diverse scientists. The Cellular and Molecular Pathology (CMP) graduate training program at the University of Wisconsin provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. According to the Commission on Pathways Through Graduate School and Into Careers, “between 2010 and 2020, about 2.6 million new and replacement jobs are expected to require an advanced degree, with a projected increase for jobs requiring a doctorate or professional degree” (www.pathwaysreport.org). The primary mission of the CMP program is to prepare graduates for diverse productive careers in biomedical and clinical research, education, industry or government and to position them to make significant contributions toward the health-related research needs of our nation. The CMP program provides graduate students with interdisciplinary and integrated training in the pathogenesis of human diseases with emphasis on molecular, cellular and biochemical approaches. We seek to increase each individual student's appreciation of how specific disease processes directly impact individual patients, while fostering the application of the student's specific research area to potential new concepts in clinical care and treatment. As basic and clinical sciences have evolved, new approaches to apply multidisciplinary knowledge in the field of medicine are required. The CMP graduate program is unique in that it encompasses both basic and clinical research, thereby providing the highest quality graduate education to the next generation of biomedical scientists.

PI_NAMEs: FABRY, ZSUZSANNA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Estrogen;Hepatitis;Liver Disease;Menopause;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide; progression to non-alcoholic steatohepatitis (NASH) cirrhosis occurs in a subset of patients and is the second leading indication for liver transplantation in the United States. Studies suggest that estrogen deficiency may be an important mechanism underlying the development of NAFLD and progression to NASH. The proposed randomized, placebo-controlled study of low-dose transdermal estrogen replacement therapy to postmenopausal women with NASH has the potential to further our understanding of this disease process and identify new therapeutic targets where few currently exist.

PI_NAMEs: BREDELLA, MIRIAM ANTOINETTE;COREY, KATHLEEN ELIZABETH;LAUER, GEORG MICHAEL;MILLER, KAREN K (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: ADD-1 protein;Age;Animals;Biopsy;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Characteristics;Cirrhosis;clinically significant;Data;design;Development;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;ECM receptor;effective therapy;elastography;Endocrinology;Epidemic;Estradiol;Estrogen deficiency;Estrogen Replacement Therapy;Estrogen Therapy;Estrogens;experience;Fatty acid glycerol esters;FDA approved;fibrogenesis;Fibrosis;Gene Expression Profile;Generations;Genes;Genetic Transcription;Hepatic;High Prevalence;Human;IL17 Signaling Pathway;Immune;Immunologics;Immunology;immunoregulation;improved;Inflammation;intrahepatic;lipid biosynthesis;Lipids;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver imaging;liver transplantation;Lobular;Low Prevalence;Machine Learning;Macrophage;Magnetic Resonance Spectroscopy;Manipulative Therapies;men;Menopause;Metabolic;Metabolic Diseases;Metabolic Pathway;Methods;Microscopy;multidisciplinary;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Ovariectomy;oxidation;Pathogenesis;Pathologic;Pathway interactions;patient subsets;placebo controlled study;Placebos;Play;Positioning Attribute;Postmenopause;Pre-Clinical Model;Premenopause;Prevalence;Prevention trial;primary endpoint;Process;prospective;Prospective Studies;Protons;Randomized;randomized placebo controlled study;Rattus;Research;Research Personnel;response;Risk;Role;second harmonic;Secondary to;sex;single-cell RNA sequencing;T-Lymphocyte;Technology;Testing;therapy development;Tissues;transcriptome sequencing;transcriptomics;transdermal estrogen;United States;Woman;Work

PROJECT_TITLE: Estrogen Administration for the Treatment of NASH in Postmenopausal Women


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Substance abuse and addiction continue to be major public health problems with enormous personal, society, and public health costs. The goal of the NIDA P30 Center at Temple University is to support high quality, innovative research on drugs of abuse, addiction, HIV, and pain. The Core facilities will provide state-of-the-art resources and expertise to enhance and expand the scope of research in the field, to promote research synergy, and provide training for future generations of researchers.

PI_NAMEs: UNTERWALD, ELLEN M (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Absence of pain sensation;Acceleration;addiction;Address;Alcohols;Animals;Behavior;behavioral economics;Biochemical Pharmacology;Caliber;Cannabinoids;career;catalyst;Cells;chemokine;Collaborations;Core Facility;cytokine;Discipline;Disease;drug of abuse;Drug Regulations;Education;Faculty;Flow Cytometry;fluorescence microscope;Fostering;Funding;Future Generations;G-Protein-Coupled Receptors;Gene Expression;Goals;Grant;Health Care Costs;HIV;HIV Infections;HIV-1;Human Resources;humanized mouse;Immunology;in vivo calcium imaging;Individual;Infection;Inflammation;innovation;Interdisciplinary Study;Investigation;Knowledge;Measures;medical schools;Mentors;Methods;miniaturize;Mission;Molecular Biology;mouse model;National Institute of Drug Abuse;Neuroimmune;Neurons;Neurotransmitters;new technology;next generation;Nicotine;novel;novel strategies;Opioid;opioid sparing;Pain;Pain management;Peer Review;Pharmaceutical Preparations;Physiological;Pilot Projects;Population;Postdoctoral Fellow;Prevention strategy;Productivity;programs;psychostimulant;Public Health;Publications;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Scientist;Self Administration;Services;Societies;Students;Substance abuse problem;Substance Addiction;synergism;System;Techniques;Technology;Therapeutic;Training;treatment strategy;United States National Institutes of Health;Universities

PROJECT_TITLE: Center on Intersystem Regulation by Drugs of Abuse


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

PROJECT_TERMS: addiction;Categories;Collaborations;Communities;Data;Development;Drug abuse;drug of abuse;Drug Regulations;Education;Effectiveness;Ensure;Equipment and Supplies;Evaluation;Evaluation Research;Expenditure;Faculty;falls;Feedback;Fostering;Funding;Future Generations;Goals;Grant;HIV;Human Resources;Individual;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;International;Investigation;investigator training;Journals;meetings;member;Mentors;Methods;National Institute of Drug Abuse;operation;organizational structure;Outcomes Research;Pain;Pathology;Pilot Projects;Postdoctoral Fellow;Preparation;Process;programs;Quality Control;Records;recruit;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;scientific organization;Scientist;Series;Services;Students;Substance abuse problem;synergism;Techniques;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Component for Institution # 264313


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: JOHNY, MANU BEN (contact)

PROJECT_TERMS: Acceleration;Action Potentials;Adrenergic Agents;Adult;Animals;Arrhythmia;Atrial Fibrillation;Binding;biophysical analysis;Calcium Channel;Calmodulin;Cardiac;Cardiac Myocytes;cardiometabolism;Cardiomyopathies;Cell Physiology;Cells;cohort;Collaborations;Complex;Coupling;Data;Defect;Development;Dilated Cardiomyopathy;Disease;Electrophysiology (science);experimental study;Fluorescence Resonance Energy Transfer;Functional disorder;genetic regulatory protein;Genetic Transcription;genome resource;genome sequencing;Health;Heart;Heart Diseases;Heart failure;Human;Hybrids;Hypertrophic Cardiomyopathy;Impairment;In Vitro;Individual;junctophilin;Knockout Mice;Leucine-Rich Repeat;Life;Link;link protein;loss of function mutation;Macromolecular Complexes;Mediating;Molecular;Morphology;Mus;Mutation;Neighborhoods;next generation;novel;novel therapeutics;Pakistan;Pathogenesis;Pharmaceutical Preparations;Phenotype;phenotypic data;Physiological;Physiology;Probability;Proteins;Proteomics;recruit;Regulation;Reporter;Role;RyR2;screening;Signal Transduction;small hairpin RNA;Structure;Testing;trafficking;Variant;Work

PROJECT_TITLE: Illuminating the function regulome of cardiac L-type Ca2+ channels in health and disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Anhedonia;animal breeding;Animal Model;Animals;Anxiety;anxiety-like behavior;Behavior;Behavior assessment;behavior test;Behavioral;behavioral economics;Behavioral Model;Brain;Breeding;Cognition;cognitive testing;Collaborations;Communities;conditioned place preference;Data;Data Analyses;drug of abuse;Drug Regulations;drug reinforcement;emotional functioning;Equipment;Ethanol;experience;Experimental Designs;experimental study;Food;Funding;Gene Modified;Generations;Goals;HIV-1;HIV/AIDS;Human Resources;humanized mouse;in vivo;in vivo evaluation;Infection;innovation;Institution;Intravenous;Knowledge;Learning;Locomotion;Measurement;Measures;member;Memory;Mental Depression;Methods;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;National Institute of Drug Abuse;negative affect;neurobiological mechanism;novel therapeutics;Oral;Pain;Pathway interactions;Pharmaceutical Preparations;preference;Procedures;programs;Rattus;Relapse;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rewards;Rodent Model;Saccharin;Scientific Advances and Accomplishments;Self Administration;Self Stimulation;skills;stereotypy;Stress;Stress Tests;Substance abuse problem;Sucrose;Techniques;Testing;Training;Transgenic Organisms;Ultrasonics;United States National Institutes of Health;Universities;vocalization;ward;Work


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The need for increased academic physician-scientists in Pediatric Critical Care Medicine, and collaborative rigorous investigation of new treatment modalities with focus on pathobiology, health disparities, and long-term morbidities is clear. The goal of the training program is to increase the number of highly trained, successfully funded and sustainable pediatric critical care physician-scientists, who will perform high level laboratory, clinical- translational, and/or health services research that will ultimately improve our understanding of the pathobiology of critical illness, improve short and long-term outcomes, and reduce the incidence of children with residual disabilities and/or chronic disease.

PI_NAMEs: FINEMAN, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TITLE: Research Training in Pediatric Critical Care Medicine


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PHILADELPHIA

PI_NAMEs: LIU-CHEN, LEE-YUAN  (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;addiction;Address;Adolescent;Adult;Affinity Chromatography;Agonist;Antibodies;Applications Grants;Area;Arrestins;Autoradiography;Award;Behavioral;beta-arrestin;Binding;Binding Sites;Biochemical;Biochemical Pharmacology;Biological Assay;Brain;cannabinoid receptor;Cannabinoids;Cell Line;Cells;Chimeric Proteins;Cholinergic Receptors;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;Cocaine;Collaborations;Country;Cultured Cells;Cyclic AMP;Data;delta opioid receptor;Dopamine;Dopamine Receptor;Drug abuse;Drug Addiction;drug of abuse;Drug Receptors;Drug Regulations;Exposure to;Funding;G-Protein-Coupled Receptors;GPR4 gene;Grant;GTP-Binding Proteins;Human Resources;Individual;innovation;Institution;interdisciplinary approach;interest;Investigation;kappa opioid receptors;Knockout Mice;Laboratories;Ligand Binding;Methods;Mitogen-Activated Protein Kinases;Morphine;Mus;Mutant Strains Mice;Nicotine;Nicotinic Receptors;nociceptin;novel;offspring;Opioid agonist;Opioid Receptor;ORL1 receptor;Peptides;Phosphorylation;Positioning Attribute;preservation;Publications;radioligand;Rattus;receptor;Receptor Activation;receptor binding;receptor expression;receptor function;receptor internalization;Receptor Signaling;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resources;Rodent;Scientist;screening;Serum;Services;side effect;sigma receptors;Signal Transduction;Signaling Protein;Specificity;Spinal Cord;Substance abuse problem;Techniques;Therapeutic Effect;tool;Training;United States National Institutes of Health;Visualization;Western Blotting


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Organ Transplantation;Rare Diseases;Stimulant Use and Misuse;Substance Misuse;Transplantation

PI_NAMEs: EISENSTEIN, TOBY K. (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Alcohols;Antibody Formation;Area;Area Analyses;Argon;arm;Biological Assay;Biological Response Modifiers;Blood - brain barrier anatomy;Blood specimen;Brain;Brain region;Cannabinoids;cathinone;Cell Culture Techniques;Cell Line;Cells;Cellular Assay;cellular imaging;chemokine;Cocaine;Collaborations;Computer software;cytokine;Dedications;Dendritic Spines;density;Dependence;Detection;drug of abuse;Drug Regulations;Educational process of instructing;Enzyme Immunoassay;Enzyme-Linked Immunosorbent Assay;Event;Exposure to;Faculty;Fluorescence;glial activation;Golgi Apparatus;Graft Rejection;Grant;high resolution imaging;Histologic;histological image;HIV Infections;Hormones;Human;human tissue;Image;Image Analysis;imaging capabilities;imaging system;Imaging Techniques;immune imaging;Immune system;Immunohistochemistry;Immunologics;Immunology;Immunology procedure;In Situ Hybridization;In Vitro;Individual;Inflammation Mediators;Institution;instrumentation;Investigation;Isometric Exercise;Laser Scanning Confocal Microscopy;Liquid substance;live cell microscopy;lymph nodes;Lymphocyte;Magnetism;Measurement;Measures;Mediator;Mentors;Methods;Microscopy;Mitogens;Mixed Lymphocyte Culture Test;Molecular;Mycoplasma;National Institute of Drug Abuse;Natural Killer Cells;Neurons;Nicotine;Opioid;Organ Transplantation;particle;Pharmaceutical Preparations;Physiological;Plasma;Process;Protein Array;Proteins;Proteome;psychostimulant;receptor expression;Research;research and development;Research Personnel;Resources;response;RNA;Rodent;Rodent Model;Role;Running;Sampling;Serum;Skin graft;Spleen;Stains;Substance abuse problem;Substance of Abuse;Substance Use Disorder;Supporting Cell;System;Techniques;Testing;theories;Tissue imaging;tissue processing;Tissue Sample;Tissues;Western Blotting;Withdrawal;Work


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine

ORG_CITY: TAMPA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed project will investigate the therapeutic and mechanistic role of apolipoprotein A1 (ApoA1) protein in repair of damaged endothelial cells (ECs), specific cells comprising the border between blood and tissues in the brain and spinal cord, using an animal model of ALS. Our studies will determine whether beneficial effects can be provided by administration of ApoA1 and elucidate the mechanism(s) of protein actions involved in EC restoration. The envisioned result is a protein-mediated therapy for vascular repair in ALS.

PI_NAMEs: BORLONGAN, CESARIO V;GARBUZOVA-DAVIS, SVITLANA NICOLAI (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Age;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Antiinflammatory Effect;Apolipoprotein A-I;Astrocytes;astrogliosis;Behavioral;Blood;blood damage;Blood Vessels;Bone Marrow;Brain;Capillary Endothelial Cell;cell injury;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;Cells;clinical application;Clinical Trials;Competence;Data;Disease;Disease Outcome;Disease Progression;efficacy evaluation;Endothelial Cells;endothelial stem cell;Endothelium;Ensure;Experimental Designs;experimental study;extracellular vesicles;Future;Gender;Goals;high reward;Histology;Homeostasis;Human;Immunohistochemistry;Impairment;In Vitro;in vitro Model;in vivo;innovation;insight;Intravenous;intravenous administration;laboratory experiment;life span;Mediating;Microglia;Microvascular Permeability;motor neuron degeneration;Motor Neurons;mouse model;Mus;Mutant Strains Mice;Natural regeneration;Neurodegenerative Disorders;Neuroglia;neuronal survival;neurovascular;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;PIK3CG gene;primary endpoint;Process;protein expression;Proteins;Publications;Random Allocation;Recovery of Function;regenerative;repair strategy;repaired;reparative process;replication factor C;Reporting;Research Design;restoration;Risk;Rodent Model;Role;Safety;Scientific Advances and Accomplishments;Signal Transduction;Spinal Cord;superoxide dismutase 1;Symptoms;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tissues;Translating;translational study;Translations;Transplantation;Treatment Efficacy;Widespread Disease;wortmannin

PROJECT_TITLE: Targeting Blood-CNS-Barrier in ALS via Apolipoprotein A1

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: RAWLS, SCOTT M. (contact)

PROJECT_TERMS: Acute;Agonist;Amino Acids;Analgesics;Animal Model;Animals;antagonist;Anti-Inflammatory Agents;Area;Biogenic Amines;Biological Markers;Body Temperature;Brain;Brain region;Calcium;career;Carrageenan;Cells;chemokine;chemokine receptor;chemotherapy;Collaborations;Communities;Conscious;Constipation;cytokine;Dependence;Discipline;Disease;Drug Addiction;drug discovery;Drug Exposure;drug of abuse;Drug Regulations;Electrophysiology (science);Equilibrium;Exposure to;extracellular;Fluorescence;Fluorescence Microscopy;Funding;Gastric Emptying;gastrointestinal function;Goals;GPR55 receptor;Hand Strength;Heart Rate;High Pressure Liquid Chromatography;HIV;HIV Infections;Image;In Vitro;in vivo;innovation;Institution;Intestines;Ligands;Link;Measurement;Methodology;Microdialysis;miniaturize;Mission;Motor;motor impairment;mu opioid receptors;Mus;National Institute of Drug Abuse;Neuroimmune;Neurons;Neuropeptides;neuroprotection;Neurotransmitters;Nociception;novel;Opiate Addiction;Opioid;Opioid Analgesics;opioid exposure;Opioid Receptor;Oxygen;Pain;pain model;painful neuropathy;Patch-Clamp Techniques;Pathology;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical Dependence;Physiological;Productivity;Rattus;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Support;Resources;respiratory;Respiratory physiology;Rewards;Rotarod Performance Test;Sampling;Science;Scientist;stimulant exposure;Substance abuse problem;Surgical incisions;Synaptic plasticity;synergism;System;Testing;Therapeutic;translational potential;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Ventilatory Depression;Weight;Withdrawal


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Substance Misuse

PI_NAMEs: ROGERS, THOMAS J (contact)

PROJECT_TERMS: addiction;Animals;Behavior;Breeding;cannabinoid receptor;Cell Line;Cells;chromatin immunoprecipitation;Cloning;Collaborations;Core Facility;design and construction;Development;Discipline;Dominant-Negative Mutation;drug action;drug of abuse;Drug Regulations;Epitopes;Evaluation;experience;experimental study;Funding;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene product;Genes;Genotype;HIV;Immune system;In Vitro;in vivo;Institution;interest;Investigation;Measures;meetings;Messenger RNA;Methodology;MicroRNAs;Molecular;Molecular Analysis;Molecular Biology;mutant;National Institute of Drug Abuse;Northern Blotting;novel;Nuclear;Opioid Receptor;Organ;Parasites;Pharmacotherapy;Plasmids;Population;Procedures;Process;promoter;Proteins;Quantitative Reverse Transcriptase PCR;receptor;receptor-mediated signaling;Research;Research Personnel;Research Project Grants;Resources;Reverse Transcriptase Polymerase Chain Reaction;Ribonucleases;RNA;Rodent;Role;Run-On Assays;Savings;service utilization;Services;Signal Transduction Pathway;System;Techniques;Time;Tissues;trafficking;Training;Transcript;transcription factor;Transfection;United States National Institutes of Health;Universities;vector;Work


PI_NAMEs: MARKS, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Address;Adrenergic Agents;Affect;Alanine;Anti-Arrhythmia Agents;Arrhythmia;Back;Binding;Binding Sites;Biological Assay;Calcium;Calcium Channel;Calcium Signaling;Calmodulin;calmodulin-dependent protein kinase II;Cardiac;Cardiomyopathies;Catecholaminergic Polymorphic Ventricular Tachycardia;Cell membrane;cell type;Cells;Chronic;ClinVar;cofactor;cohort;Complex;Congestive Heart Failure;Consanguinity;Coupling;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Disease;drug discovery;Endoplasmic Reticulum;Exercise;FKBP1B gene;Functional disorder;gain of function;gain of function mutation;Genetic;genome resource;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;heart function;Human;human model;Impairment;In Vitro;in vivo evaluation;Individual;Inherited;junctophilin;Ligands;Link;Location;Mediating;Missense Mutation;Molecular;Morbidity - disease rate;mortality;mouse model;Movement;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myocardial dysfunction;Myocardium;Myopathy;nanobodies;novel;novel therapeutics;Outcome;oxidation;Pakistan;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;phenotypic data;Phosphorylation;Phosphorylation Site;Physiology;Post-Translational Protein Processing;Pre-Clinical Model;prevent;Proteins;receptor function;Recombinants;Regulation;research clinical testing;Resolution;Role;Ryanodine Receptor Calcium Release Channel;RyR1;Sarcoplasmic Reticulum;Signal Transduction;Site;small molecule;Stress;Structure;Structure-Activity Relationship;Sudden Death;Testing;United States National Institutes of Health;Variant;Ventricular Arrhythmia;Work

PROJECT_TITLE: Ryanodine receptor structure and function in heart failure


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Transcription hubs are hotspots in the genome with elevated transcription activities. The proposed research seeks to understand how transcription hubs assemble on the endogenous DNA loci in cell, and how they engage with enhancer and promoter to activate transcription. This work will have implications to various diseases where transcription hub is dysregulated, such as neurodegeneration and cancer.

PI_NAMEs: CAI, DANFENG  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Biophysics;Cell Nucleus;Cell Proliferation;Cell Survival;cell type;Cells;Chromatin;Color;Disease;DNA;Enhancers;Genes;Genetic Transcription;Genome;Goals;Image;Impairment;interest;Lead;Liquid substance;live cell imaging;Malignant Neoplasms;Mediating;Molecular;Nature;Nerve Degeneration;Nucleic Acids;particle;Phase;Positioning Attribute;Postdoctoral Fellow;promoter;Proteins;Proteomics;Research;Signal Transduction;Stress;System;Techniques;Testing;Time;Transcription Coactivator;Transcriptional Activation;Visualization;Work

PROJECT_TITLE: Probing the Formation and Function of Transcription Hubs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


PI_NAMEs: ADLER, MARTIN W (contact)

PROJECT_TERMS: Absence of pain sensation;addiction;Address;Alcohols;Applications Grants;Area;Award;Basic Science;Behavioral;Biology;Cannabinoids;career;Clinical Sciences;Collaborations;Data;Discipline;Drug abuse;drug of abuse;Drug Regulations;Faculty;Feasibility Studies;Fostering;Funding;Generations;Grant;HIV;Immunologics;innovation;Institution;Interdisciplinary Study;meetings;Mentors;Molecular;National Institute of Drug Abuse;Nicotine;novel;Opioid;Outcome;Pain;Pharmaceutical Preparations;pharmacologic;Physiological;Pilot Projects;Probability;psychostimulant;Publications;Reporting;Research;research facility;Research Personnel;Research Project Grants;Research Support;Substance abuse problem;Substance Addiction;Techniques;Testing;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The MDNM training program supports the rigorous education of diverse graduate students in the mechanisms of neurodegeneration, thus expanding the pool of scientists searching for disease-modifying therapies for these devastating diseases. It is expected that graduates will go on to leading positions in universities, research institutes, and industry, where their research will advance therapeutic treatments for neurodegenerative disorders that afflict society.

PI_NAMEs: CHANDRA, SREEGANGA S;STRITTMATTER, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: multimodality;Nerve Degeneration

PROJECT_TITLE: Multimodal Delineation of Neurodegenerative Mechanisms


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Lipid-based nanoparticles (LNPs) are the most powerful material for drug and gene delivery with multiple systems currently in use such as the mRNA COVID-19 vaccine and many more under clinical trials. One of the biggest challenges in RNA and DNA delivery is the process at which LNPs must evade endosomal entrapment. Membrane fusion and fusion-pore formation is the main mechanism of LNP and nucleic acid endosomal escape but how these processes occur in living systems is still not well understood. In this proposal we will develop a microscopic understanding of LNP-endosome fusion and explore a new handle, tuning the often-ignored Gaussian modulus of membranes, to design super fusogenic LNPs.

PI_NAMEs: LEAL, CECILIA MARIA (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affect;Binding;Biological Assay;Biophysics;Cell Line;cell type;Cells;Cholesterol;chronic infection;Clinical;Clinical Trials;Communication;Confocal Microscopy;COVID-19;COVID-19 vaccine;Cryoelectron Microscopy;Cytosol;Data;delivery vehicle;design;Diffuse;Disease;DNA delivery;Drug Delivery Systems;Elasticity;Endocytosis Pathway;endosome lumen;endosome membrane;Endosomes;Eukaryotic Cell;Evaluation;Event;Evolution;experimental study;FDA approved;Flow Cytometry;Fluorescence Resonance Energy Transfer;fluorophore;Formulation;Gene Delivery;Generations;Genetic Diseases;Goals;Health;Human;innovation;insight;interdisciplinary approach;Label;lipid nanoparticle;Lipids;Malignant Neoplasms;Measures;Membrane;membrane activity;Membrane Fusion;Membrane Proteins;Messenger RNA;Microfluidics;Microscopic;microscopic imaging;mimetics;Modeling;models and simulation;Modulus;Molecular;molecular modeling;mRNA delivery;nanoparticle delivery;novel strategies;Nucleic Acids;Organism;Pathway interactions;Phase;Phospholipids;Process;Property;protein expression;protein purification;Proteins;Proton Pump;reconstitution;Research Support;RNA delivery;Roentgen Rays;Role;Rupture;Saccharomyces cerevisiae;Series;simulation;Spectrum Analysis;Stress;Swelling;System;Testing;Therapeutic;therapeutic RNA;unilamellar vesicle;vacuolar H+-ATPase;Virus;Work;Yeasts

PROJECT_TITLE: Endosomal escape of lipid-based nanoparticles comprising Gaussian curvature lipids

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_DEPT: NEUROLOGY

PHR: Project Narrative: Stroke and other neurodegenerative disorders are a leading cause of death, disability and loss of quality of life. The project objectives are to understand the actions of Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN) also known as MIF in stroke and determine whether a first in class, MIF nuclease inhibitor is protective in stroke models and explore the contributions of PAAN/MIF’s nuclease activity in the activation of cGas and STING pathway and subsequent NLRP3 activation. These finding could offer innovative therapeutic approaches to treat neurodegenerative diseases and stroke.

PI_NAMEs: DAWSON, TED M. (contact);DAWSON, VALINA L.

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;analog;Apoptosis;apoptosis inducing factor;Biochemical;Brain;Brain Injuries;Caspase;Cause of Death;Cell Death;Cell Nucleus;cell type;Cells;Cerebral Infarction;Cerebral Ischemia;Cessation of life;Chronic;Complex;Deoxyribonucleases;Development;disability;Disease;DNA Damage;DNA Fragmentation;excitotoxicity;Female;Genomic DNA;Glutamates;Human;In Vitro;in vivo;Inflammasome;inhibitor;innovation;Ischemia;ischemic injury;Ischemic Stroke;Knock-in Mouse;Laboratories;Macrocyclic Compounds;male;Mediating;Mediator;Microglia;Middle Cerebral Artery Occlusion;Mitochondria;Modeling;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Injury;Neurons;neuroprotection;neurotoxicity;nuclease;Pathway interactions;Penetrance;Peroxonitrite;Play;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymers;prevent;Quality of life;Rattus;Reactive Oxygen Species;recruit;release factor;response;Role;Safety;Stimulator of Interferon Genes;Stimulus;Stroke;stroke model;Therapeutic;therapeutic target

PROJECT_TITLE: Parthanatos, PAAN/MIF nuclease Activation in Ischemic Injury

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Although some risk factors for urinary stone disease are known, including urinary supersaturation, other pathogenic events remain elusive. Our preliminary data suggests that altered populations of renal inflammatory cells may contribute to urinary stone risk. We propose formation of a multidisciplinary team that includes early-stage investigators to rigorously investigate renal inflammatory cells in a novel animal model and human stone patients in order to provide important preliminary data for future grant applications.

PI_NAMEs: LIESKE, JOHN C (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Affect;Age Months;Animal Experiments;Animal Model;Anti-Inflammatory Agents;Applications Grants;Automobile Driving;Biological Markers;Blood;Breeding;brushite;calcification;Calcium;calcium excretion;Calcium Oxalate;calcium phosphate;Cell secretion;Cells;chemokine;Clinic;Clinical;clinical investigation;Clinical Investigator;Clinical Treatment;Communities;comparison control;Complement;cost;County;Crystal Formation;Crystallization;cytokine;Data;Dedications;Defect;Deposition;design;Development;Disease;Disease Management;Duct (organ) structure;Economic Models;Education;Effectiveness;Event;Excretory function;exosome;experience;Experimental Animal Model;experimental study;extracellular vesicles;follow-up;Fostering;Frequencies;Future;Genitourinary system;Goals;Grant;Growth;Hematology;Human;human tissue;Hydroxyapatites;hypercalciuria;improved;In Vitro;Incidence;Infection;Inflammatory;inflammatory marker;innovation;insight;Interdisciplinary Study;interstitial;Investigation;Kidney;Kidney Calculi;Knockout Mice;Knowledge;Lesion;Life;Macrophage;Medical Care Costs;men;Mentorship;microvesicles;Modeling;Molecular;monocyte;Morbidity - disease rate;mouse model;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;new therapeutic target;non-invasive monitor;novel;Pain;Pathogenesis;Pathogenicity;Patients;personalized management;Persons;Phagocytes;Phenotype;Physiology;Play;Population;Positioning Attribute;Predisposition;Prevalence;prevent;Prevention;Prevention strategy;Productivity;programs;Recurrence;Renal Tissue;Renal tubule structure;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;Scientist;Seasons;skills;societal costs;Spatial Distribution;Surgeon;synergism;therapeutic target;tool;translational scientist;translational study;Tubular formation;ultrasound;United States;urinary;Urinary Calculi;Urine;Urologic Diseases;Urology;Woman;Work

PROJECT_TITLE: Renal macrophages in the pathogenesis of human urinary stones and Randall's plaque formation in mice


NIH_SPENDING_CATS: Kidney Disease;Urologic Diseases

PROJECT_TERMS: Address;Adherence;Advisory Committees;Biomedical Engineering;Budgets;catalyst;Clinic;Communication;Communities;Complement;Data;design;Disease;Education;effectiveness research;Ensure;Feedback;Fellowship Program;Future;Goals;Human;Human Resources;interest;Journals;Kidney;Kidney Calculi;Leadership;Macrophage;meetings;member;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;operation;outreach;Pathogenesis;Performance;Physiology;Process;Productivity;programs;Reporting;Research;Research Personnel;Research Project Grants;Resources;Series;Structure;Students;undergraduate research;Urinary Calculi;urologic;Urologist;Urology;Vision

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed studies in rodent models will yield essentially the first comprehensive test of the hypothesis that chronic stress accelerates transcriptional markers of brain aging. The studies will illuminate sex differences in stress and stress hormone responsiveness and the potential protective and mediating roles, respectively, of progesterone and SGK1 (a key effector in glucocorticoid system signaling) in gray and white matter. Even if our working hypotheses are rejected, the proposed studies should have translational value for geriatric medicine.

PI_NAMEs: BLALOCK, ERIC  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;Acute;acute stress;Address;Age;age acceleration;age effect;Age Months;aged;Aging;aging biomarker;aging brain;aging related;Agonist;animal age group;antagonist;anxiety-related behavior;Astrocytes;Behavioral;Bilateral;Binding;biological adaptation to stress;Biological Assay;Biological Markers;Blood;cell type;Cells;Chronic;Chronic stress;Clinical;Cognitive;Corticosterone;cytokine;Data;Dependence;Dimethyl Sulfoxide;Dose;Female;female sex hormone;Gene Expression Profile;Genes;Genetic Transcription;Geriatrics;Glucocorticoid Receptor;Glucocorticoids;Gonadal Steroid Hormones;gray matter;Health;Hippocampus;Hormone Responsive;Hormones;Hypertrophy;Immunohistochemistry;indexing;Injury;intervention effect;Intraperitoneal Injections;Knowledge;laser capture microdissection;male;Measures;Mediating;Mediator;Microglia;Microinjections;Mifepristone;Modeling;morris water maze;mRNA Expression;Myelin;nano-string;neuroinflammation;Neurons;novel;novel strategies;Oligodendroglia;Oral;Outcome;Outcome Measure;overexpression;pharmacologic;Phosphotransferases;Preparation;Process;Progesterone;Rattus;receptor;reproductive hormone;Research Support;response;Rodent Model;Role;Serum;sex;Sex Differences;Signal Pathway;Signal Transduction;Slice;Stress;stress reduction;Stress Tests;System;Testing;Therapeutic Uses;Tissues;transcriptome sequencing;treatment group;Up-Regulation;uptake;Viral;white matter;women subjects;Work

PROJECT_TITLE: Chronic Stress, Glucocorticoids, and Progesterone in Brain Aging

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Prevention;Urologic Diseases

PHR: PROJECT NARRATIVE Although some risk factors for urinary stone disease are known, including urinary supersaturation, other pathogenic events remain elusive. Our preliminary data suggests that altered populations of renal inflammatory cells may contribute to urinary stone risk. We propose formation of a multidisciplinary team that includes early-stage investigators to rigorously investigate renal inflammatory cells in a novel animal model and human stone patients. This P20 center will provide important preliminary data for future grant applications.

PROJECT_TERMS: Affect;Age Months;Aging;Animal Model;Animals;Anti-Inflammatory Agents;Applications Grants;Area;biobank;Biological Markers;Biopsy;Blood;brushite;calcification;Calcium;Calcium Oxalate;calcium phosphate;Cell secretion;Cells;chemokine;Clinical;comparison control;cost;Crystal Formation;Crystallization;cytokine;Data;Defect;Deposition;design;Development;Disease;Duct (organ) structure;Effectiveness;Epithelial Cells;Event;Excretory function;exosome;experience;Experimental Animal Model;extracellular vesicles;Frequencies;Future;Grant;Growth;Human;human tissue;Hydroxyapatites;hypercalciuria;Hyperoxaluria;In Vitro;Individual;Inflammatory;inflammatory marker;innovation;interstitial;Kidney;Knock-out;Knockout Mice;Liquid substance;Macrophage;Maps;men;Mentorship;Metabolic Diseases;microvesicles;monocyte;Morbidity - disease rate;mouse model;multidisciplinary;Mus;new therapeutic target;non-invasive monitor;novel;Operative Surgical Procedures;Pain;Papillary;Pathogenesis;Pathogenicity;Patients;Persons;Phagocytes;Phagocytosis;Phenotype;Play;Population;potential biomarker;Prevention;Process;prospective;recruit;Recurrence;Renal Tissue;Renal tubule structure;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;Salts;Sampling;Scientist;Signaling Molecule;skills;Spatial Distribution;Surface;Surgeon;Testing;Tissues;Tubular formation;urinary;Urinary Calculi;Urine;Urologic Diseases;Virulence Factors;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Research Project


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Genetics;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Completion of the experiments in this proposal will bolster our knowledge about how sensory systems represent the environment and the extent to which these representations are tailored to the behavioral needs of animals. The insights gained should, in the long term, be applicable to the development of machine-brain interfaces and treatments for sensory and nervous system disorders. Such development would reduce illness and disability, thereby enhancing quality of life.

PI_NAMEs: EMANUEL, ALAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Afferent Neurons;Animal Behavior;Animals;Area;awake;Behavior;Behavior monitoring;Behavioral;Brain;brain machine interface;career;career development;Central Nervous System;Chronic;Communities;Complex;Computer Models;Computer Vision Systems;Custom;Cutaneous;Dedications;Detection;Development;Development Plans;disability;Discrimination;Electrodes;Electrophysiology (science);Environment;experimental study;Felis catus;flexibility;Genetic;genetic approach;genetic manipulation;Goals;in vivo;Inherited;insight;International;Joints;Knowledge;Laboratories;Learning;loss of function mutation;Manuscripts;mechanical device;Mechanoreceptors;Mediating;medical schools;meetings;Methods;Modeling;Modernization;mouse genetics;Movement;Mus;Nervous System Disorder;neural;neural circuit;Neurobiology;Neurons;novel;optogenetics;Organism;Patients;Perception;Performance;Peripheral;Peripheral Nervous System;Positioning Attribute;Postdoctoral Fellow;prevent;Primates;Process;Property;Publications;Quality of life;recruit;Research;Research Personnel;Resources;response;responsible research conduct;Rewards;Role;Sensory;sensory system;Signal Transduction;Skin;somatosensory;Somatosensory Cortex;Speed;Spinal Cord;Stimulus;Structure;System;Tactile;Testing;Thalamic structure;Touch sensation;Training;Work

PROJECT_TITLE: Contextual Representation of Tactile Information in Mouse Primary Somatosensory Cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Radiomics models, or imaging biomarkers, have been proposed to allow automatic computer-aided diagnosis, classification, and scoring of various diseases based on imaging study data. Radiomics research and development is a rapidly growing field with the increasing availability of large imaging databases and access to sophisticated software and modeling tools; however, successful radiomics models typically require careful data curation and understanding to limit variability associated with the imaging chain (in contrast to the desired variability in the underlying patient anatomy which contains the target biomarkers). This work seeks to provide a rigorous mathematical framework with models for predicting the undesirable variability associated with the imaging device, acquisition protocol, and data processing; as well as strategies for standardization across those dependencies to rigorously estimate the underlying imaging biomarkers, thus permitting high-performance radiomics model development and application across a broad range of data sources.

PI_NAMEs: GANG, JIANAN GRACE;STAYMAN, JOSEPH WEBSTER (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3D Print;Affect;Anatomy;Area;Asthma;Attention;Back;Biological Models;Biology;Black Box;Body System;Cadaver;Calibration;Categories;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical translation;Communities;Computed Tomography Scanners;Computer software;Computer-Assisted Diagnosis;computerized data processing;Custom;Data;Data Collection;data curation;Data Set;Data Sources;data standards;Databases;Dependence;Diagnostic;digital;Disease;disease classification;Environment;Evaluation;Excision;experimental study;falls;feature selection;Glass;Image;imaging biomarker;Imaging Device;imaging modality;imaging properties;imaging study;imaging system;improved;Institution;Interstitial Lung Diseases;Investigation;Lung;Lung Diseases;lung imaging;Machine Learning;Malignant neoplasm of lung;Mathematics;Measures;Methodology;Methods;microCT;model building;model development;Modeling;Noise;Normal Range;Output;Patient imaging;Patient-Focused Outcomes;Patients;Pattern;Performance;predictive modeling;prevent;Protocols documentation;Pulmonary Fibrosis;quantitative imaging;Radiology Specialty;radiomics;reconstruction;Recovery;Reporting;Research;research and development;Resolution;Scanning;Series;simulation;Site;Specific qualifier value;Specimen;Standardization;Structure of parenchyma of lung;System;targeted biomarker;Techniques;Technology;Testing;Texture;Theoretical model;Time;tool;Tuberculosis;Validation;Vendor;Work;X-Ray Computed Tomography

PROJECT_TITLE: Framework for radiomics standardization with application in pulmonary CT scans


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE In the mammalian intestine, Lgr5+ stem cells (ISCs) drive the rapid renewal of the intestinal lining and its adaptation to diet including to fasting, which enhances the ability of ISCs to repair damage after injury. Although fasting extends lifespan and promotes health in mammals, little is known about how it stimulates the function of ISCs to mediate this repair process in the intestine or how fasting-induced changes in ISCs impact intestinal tumorigenesis—a process often initiated by stem cells. In this proposal, we will investigate the mechanisms by which fasting mediates intestinal stemness and how fasting contributes to intestinal tumor initiation, progression and treatment.

PI_NAMEs: YILMAZ, OMER  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acetyl Coenzyme A;adult stem cell;Affect;Agonist;APC gene;beta-Hydroxybutyrate;biosynthetic product;Cells;Coenzyme A;Colon;Colon Carcinoma;Diet;Engineering;Enzymes;extend lifespan;Fasting;fatty acid oxidation;gene repression;HDAC1 gene;Health;Health Promotion;Histone Deacetylase Inhibitor;Human;improved;in vivo;Injury;insight;Intestinal Cancer;Intestinal Neoplasms;intestinal tumorigenesis;Intestines;ketogentic;Ketone Bodies;Ketones;LGR5 gene;Ligase;Malignant Neoplasms;Mammals;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;Natural regeneration;Nonesterified Fatty Acids;novel;novel therapeutics;Organoids;oxidation;Pathway interactions;Physiological;Population;PPAR delta;prevent;Process;Production;programs;Regimen;repaired;response;Role;Secretory Cell;Signal Transduction;Small Intestines;Source;stem cell aging;stem cell function;stem cells;stemness;Testing;Therapeutic;tissue repair;Tissues;transplant model;tumor;tumor growth;tumor initiation;tumor progression;tumorigenesis;Whole Organism;Work

PROJECT_TITLE: Impact of fasting on intestinal stem cells and cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]