NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE The PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study involves a multidisciplinary collaboration between Kaiser Permanente Northern California and Kaiser Permanente Hawaii integrated healthcare delivery systems to address key knowledge gaps related to the epidemiology of cardiovascular disease in >800,000 members across Asian American, Native Hawaiian and other Pacific Islander subgroups and also compared with >1.7 million non-Hispanic Whites. The study will address contemporary rates and prediction of incident heart failure, atrial fibrillation and acute myocardial infarction between these subgroups, along with linking comprehensive electronic health records, external data sources, patient self-reported data, as well as a biorepository of blood specimens to better evaluate potential exposures that may explain variation in major cardiovascular diseases across Asian American, Native Hawaiian and other Pacific Islander subgroups. Collectively, insights from the PANACHE Study will promote improvements in personalized care and cardiovascular outcomes across different Asian American, Native Hawaiian and Pacific Islander subpopulations which represent the fastest growing set of ethnic groups in the U.S.

PI_NAMEs: GO, ALAN S (contact)

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Accident and Emergency department;Acute myocardial infarction;Address;Adult;advanced analytics;American;Artificial Intelligence;Asian Americans;Asian population;Atherosclerosis;Atrial Fibrillation;Behavioral;biobank;Blood;blood pressure elevation;Blood specimen;California;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Chinese;Clinical;clinical risk;Collaborations;Collection;computer infrastructure;Data;Data Analytics;Data Reporting;Data Sources;demographics;Diabetes Mellitus;Dietary Factors;Dyslipidemias;East Asian;Electronic Health Record;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;ethnic difference;Ethnic Population;experience;Filipino;Goals;Hawaii;Heart failure;Heterogeneity;improved;Incidence;Individual;Inpatients;insight;Integrated Delivery of Health Care;Interdisciplinary Study;Knowledge;Life Style;Link;Machine Learning;member;Methods;multidisciplinary;Myocardial Infarction;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;novel;Obesity;Outcome;Outpatients;Patient Self-Report;patient subsets;Patients;Pattern;personalized care;Pharmaceutical Preparations;Population;Population Group;Predictive Analytics;predictive modeling;prospective;Public Health;Quality of Care;recruit;Reporting;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;social culture;sociocultural determinant;sociodemographics;South Asian;southeast Asian;Specimen;Subgroup;success;System;Variant

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: STREBLOW, DANIEL N (contact)

PROJECT_TERMS: Affect;Allogenic;beta-Chemokines;Binding;Bone Marrow Transplantation;C-terminal;CCL2 gene;CD34 gene;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cells;Cercopithecine Herpesvirus 1;chemokine;chemokine receptor;Collaborations;Couples;CX3C Chemokines;Cytomegalovirus;Data;Development;Dissection;Epidermal Growth Factor Receptor;Fractalkine;functional outcomes;gene product;Genes;Goals;graft failure;Graft Rejection;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;humanized mouse;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;inhibitor;knock-down;Ligand Binding;Ligands;Link;Mediating;MEKs;member;MicroRNAs;Molecular;monocyte;Morbidity - disease rate;mortality;mutant;Mutation;Mutation Analysis;Myelogenous;Myelosuppression;N-terminal;neutralizing antibody;novel therapeutics;Organ;Organ Transplantation;Pathway interactions;PIK3CG gene;Play;Point Mutation;Population;prevent;Process;Productivity;programs;Proliferating;Proteins;RANTES;reactivation from latency;Receptor Signaling;Recombinant Delta Chemokine;Regulation;rho;Role;sensor;sensor technology;Signal Pathway;Signal Transduction;Signaling Molecule;Solid;Stem cell transplant;System;Tail;Time;Transplant Recipients;Undifferentiated;Viral;Viral Proteins;Virus;Virus Latency

PROJECT_TITLE: HCMV US28 regulation of host cell signaling in viral latency and reactivation


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Biotechnology;Clinical Research;Genetics;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Posttraumatic osteoarthritis (PTOA) is a common occurrence after anterior cruciate ligament (ACL) rupture independently of patient treatment, which indicates that early cellular and molecular changes directly after injury seem to be critical in disease development. The goal of this proposal is to investigate the relationship between biological response to injury measured in synovial fluid (soluble biomarkers and genomic profile of extracellular vesicles) and the joint damage after injury and its subsequent progression. Our research will identify imaging and biological markers predicting joint degradation at 3 and 6 years after injury and validate them for the clinical application.

PI_NAMEs: KIRSCH, THORSTEN  (contact);RUIZ GARZON, MARIA AMPARO

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acute;Address;Age Years;anterior cruciate ligament injury;anterior cruciate ligament rupture;articular cartilage;biobank;Biological;Biological Markers;Biological Testing;biomarker panel;candidate marker;Cartilage;cell type;Cells;Clinical;clinical application;Clinical assessments;Clinical Research;cohort;Complex;Complication;cost effective;Development;diagnostic tool;Diffusion Magnetic Resonance Imaging;disability;Disease;Early Diagnosis;Environment;Event;extracellular vesicles;Failure;Fatty acid glycerol esters;follow-up;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;genomic biomarker;genomic profiles;Genomics;Goals;healing;Homeostasis;Image;imaging biomarker;imaging modality;Inflammation;Injury;Intervention;joint destruction;joint injury;Joints;Link;Lipid Bilayers;Lipids;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Meniscus structure of joint;Methods;Molecular;novel diagnostics;older patient;Operative Surgical Procedures;Orthopedic Surgery;Outcome;outcome prediction;Parents;participant enrollment;particle;Pathology;Patients;Phase;Play;Population;Positioning Attribute;posttranscriptional;predictive marker;predictive panel;predictive tools;Prevalence;prevent;prospective;Proteins;recruit;Research;response;response to injury;Risk Factors;RNA;Role;Sampling;Severities;Symptoms;Synovial Fluid;Testing;Time;tissue degeneration;Tissue-Specific Gene Expression;Tissues;tool;Traumatic Arthropathy;Untranslated RNA;Validation

PROJECT_TITLE: Genomic and Imaging Markers to Understand and Predict Progression of Joint Damage After Injury


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

PI_NAMEs: CAPOSIO, PATRIZIA  (contact)

PROJECT_TERMS: Allogenic;Apoptosis;Binding;C-terminal;CD34 gene;Cell Differentiation process;Cell Survival;Cells;Cellular biology;Chemicals;chronic infection;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasmic Tail;Data;Development;Disease;Epidermal Growth Factor Receptor;Event;experimental study;Family;Family member;FLT3 gene;FOXO3A gene;Genes;Goals;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Herpesviridae;Human;humanized mouse;Immunocompromised Host;Impairment;improved outcome;In Vitro;in vivo;Infection;inhibitor;Label;Ligands;Macrophage;Mediating;member;MicroRNAs;monocyte;Morbidity - disease rate;mortality;Mutagenesis;mutant;N-terminal;Organ Transplantation;Pathway interactions;Physiology;Play;Population;Post-Translational Protein Processing;prevent;Process;Proteins;Publications;Publishing;reactivation from latency;receptor;Recombinants;Regulation;rho;rho GTP-Binding Proteins;RNA Splicing;Role;sensor;Shapes;Signal Pathway;Signal Transduction;small hairpin RNA;Solid;Tail;Time;Tissues;Transcript;transcription factor;Transfection;Transplant Recipients;Viral;Virus;virus host interaction;Virus Latency;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of HCMV UL7-8 genes in the regulation of host cell signaling during viral latency and reactivation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Contact PI/PD: Pedapati, Ernest NARRATIVE Fragile X Syndrome (FXS) is a leading cause of inherited autism and intellectual disability, and despite a tremendous body of multi-species translational and clinical investigation, breakthroughs in treatments have not been forthcoming. We seek to address two major causes of this discrepancy by a systematic study of the basis of individual heterogeneity and higher-level cognitive symptomatology through the application of novel analytics of transient, non-continuous events and computation modeling of empirical data and implementation of a double-blind, individualized closed-loop auditory entrainment perturbation study to isolate neural targets associated with sensory hyperarousal and statistical learning.

PI_NAMEs: PEDAPATI, ERNEST VIJAY (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 10 year old;Acute;Address;Age;Animal Model;Auditory;autism spectrum disorder;autism symptoms;Behavior Therapy;biophysical model;Brain;Clinical;clinical investigation;clinical phenotype;Cognition;Cognitive;cognitive disability;cognitive function;cognitive process;cognitive testing;cohort;Collection;Computer Models;computerized;Cross-Over Studies;Data;Development;Diagnosis;Disease;disorder control;Double-Blind Method;Early Intervention;effective therapy;Electroencephalography;Electrophysiology (science);Event;Fragile X Syndrome;Frequencies;Functional disorder;Genotype;Heterogeneity;Human;Impaired cognition;Impairment;improved;Individual;individual variation;Inherited;Intellectual functioning disability;Knock-out;Knockout Mice;Knowledge;Language;Learning;Link;male;Measures;Mechanics;Modeling;Molecular;mosaic;mouse model;Mus;Mutation;neural;Neurobehavioral Manifestations;Neurodevelopmental Disorder;neuromechanism;neuropsychiatric symptom;neuropsychiatry;Noise;novel;Participant;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Phenotype;Proxy;psychologic;Publications;Publishing;Reaction Time;Reproducibility;response;Rest;Sampling;Sensory;Sensory impairment;sex;Signal Transduction;statistical learning;Stimulus;Structure;Subgroup;success;symptomatology;Testing;Translating;translational impact;Translational Research;United States National Institutes of Health;Variant;Visit;Wild Type Mouse;Youth

PROJECT_TITLE: FX ENTRAIN: Perturbation of neurodynamics underlying sensory hyperarousal and statistical learning in Youth with FXS

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: YUROCHKO, ANDREW D (contact)

PROJECT_TERMS: Address;Animal Model;arm;Biological;Biology;CD34 gene;Cell Differentiation process;Cell Reprogramming;cell type;Cells;Chemicals;clinically relevant;Critical Pathways;Cytomegalovirus;Cytomegalovirus Infections;Data;design;directed differentiation;Disease;Environment;Epidermal Growth Factor Receptor;Event;Experimental Designs;Failure;Funding;Gene Mutation;gene product;Genetic Transcription;Goals;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;humanized mouse;immune checkpoint blockade;improved outcome;in vivo;Infection;inhibitor;insight;knock-down;Knowledge;Laboratories;latent infection;latent virus activation;Link;Macrophage;MicroRNAs;Modification;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;mouse model;Multiomic Data;multiple omics;mutant;Myelogenous;Myeloid Cells;novel;Organ Transplantation;pathogen;Pathway interactions;permissiveness;Phenotype;Play;prevent;Prevention;Process;Productivity;programs;reactivation from latency;Regulation;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;small hairpin RNA;Solid;SRC gene;stem cell model;Testing;therapeutic target;Time;Tissues;Translating;Transplant Recipients;Viral;Viral Genes;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: HCMV regulation of monocyte/macrophage host cell signaling in viral reactivation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative The proposed study is relevant to public health because the equitable and efficient implementation of medicine disposal programs at pharmacies is expected to increase secure disposal of unused opioid medications following treatment. Subsequently, there would be a decrease in the quantity of excess prescription opioids available to be diverted for misuse. The proposed research is relevant to NIDA's priorities to implement and evaluate theoretically-based, prevention interventions that can be implemented in healthcare settings to elicit population-level impacts to address the ongoing opioid crisis.

PI_NAMEs: EGAN, KATHLEEN LOUISE (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;African American;Awareness;Behavior;Belief;Black race;Characteristics;Cities;combat;Communities;comparative efficacy;Consolidated Framework for Implementation Research;cost;Data;data integration;Education;efficacy study;Equity;expiration;falls;Friends;Goals;health care settings;health determinants;health disparity;Health Professional;Home;implementation determinants;implementation evaluation;implementation trial;improved;Inequity;innovation;Interview;Knowledge;Law Enforcement;Leadership;Link;Location;Logistic Regressions;Medicine;member;Morbidity - disease rate;mortality;National Institute of Drug Abuse;neighborhood disadvantage;Neighborhoods;nonmedical use;Opioid;opioid disposal;opioid epidemic;Outcome;overdose death;Patient Self-Report;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Population;prescription opioid;prescription opioid misuse;Prevalence;prevent;preventive intervention;primary outcome;programs;prospective;Public Health;Randomized;Reporting;Research;research study;Resources;Sampling;Secure;Site;Source;Structure;Testing;United States;Unused prescription;Visit

PROJECT_TITLE: Assessing Implementation of Pharmacy-Based Medication Disposal Programs: National Estimates, Neighborhood Inequities, and Determinants of Implementation

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE These studies in jawless vertebrates will yield insight into the basic evolutionary and functional principles by which the T cell arm of the adaptive immune system contributes to the discrimination of non-self and the maintenance of healthy self. A newly recognized family of variable lymphocyte receptors that are part of the T cell-associated system will be characterized.

PI_NAMEs: COOPER, MAX DALE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;arm;B-Lymphocytes;Cell Physiology;Cell Separation;Cells;Cellular biology;Characteristics;Complex;CRISPR/Cas technology;Cytoplasmic Tail;Development;Discrimination;Distant;Family;feeding;Gene Expression Profile;Genes;Genome;Genomics;Hagfish;Immunoglobulin Domain;Immunoglobulins;innovation;insight;Integral Membrane Protein;Investigation;ITAM;Jaw;Lampreys;Larva;Leucine-Rich Repeat;leucine-rich repeat protein;Lymphocyte;Lymphocyte Subset;Maintenance;Mass Spectrum Analysis;Mediating;Monoclonal Antibodies;Mutate;Names;Nature;novel;Orthologous Gene;Petromyzon marinus;Phosphotransferases;Phylogenetic Analysis;Phylogeny;Proteins;receptor;receptor expression;Receptor Signaling;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;src Homology Region 2 Domain;Structure;Surveys;System;T cell differentiation;T-Cell Receptor;T-Lymphocyte;Tissues;Transcript;Vertebrates;ZAP-70 Gene;γδ T cells

PROJECT_TITLE: T Cell Differentiation and Diversification in Jawless Vertebrates

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative The mechanism of Hepatitis B Virus (HBV) capsid assembly, defined with previous funding, has led to identifying an Achilles’ heel in the he HBV lifecycle and contributed to development of assembly-directed antivirals. We now use that understanding to re-engineer capsid assembly and disassembly to yield a programmable, self-assembling system for delivering macromolecules to specific cells.

PI_NAMEs: ZLOTNICK, ADAM  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Affinity;Allosteric Regulation;Anti-viral Agents;Antibodies;Behavior;Binding;Biochemistry;Biological Assay;Biophysics;Biotechnology;Capsid;Capsid Proteins;Cells;Charge;Chemicals;Chemistry;Chronic;Chronic Hepatitis B;Complex;Crowding;Cytoplasm;Data;delivery vehicle;Detection;Development;Devices;dimer;Dissociation;DNA biosynthesis;Endosomes;Engineering;Environment;Epitopes;Exposure to;falls;flexibility;Funding;Genome;Goals;Growth;Hepatitis B Virus;human pathogen;improved;in vivo;Kinetics;Learning;Life Cycle Stages;Ligand Binding;Link;macromolecule;man;Mass Spectrum Analysis;Measures;Metabolic;Methods;Modeling;Modification;Molecular Biology;Oxidation-Reduction;Paper;particle exposure;Penetration;Peptides;practical application;preservation;protein purification;Proteins;Reaction;Reagent;receptor;receptor binding;Research;response;RNA;Roentgen Rays;Role;seal;self assembly;Self Correction;Signal Transduction;single molecule;small molecule;Structure;Surface;System;Techniques;Technology;Testing;Text;Thermodynamics;Time;tool;Variant;Viral;Viral Genome;Viral Packaging;viral RNA;Virus;Virus Assembly;Virus Diseases;Virus-like particle

PROJECT_TITLE: Multimode Observation of Virus Capsid Assembly

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Electronic Nicotine Delivery Systems;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Tobacco;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

ORG_STATE: CA

PHR: Narrative This project aims to investigate the role of electronic cigarette (E-Cig)-induced growth of breast tumor using xenograft models following injection of human breast cancer cells obtained from African American (AA) and Caucasian (CA) origins. We will explore the intermediate role of oxidative stress-and reprograming of tumor microenvironment to identify key molecular targets involved during E-Cig- induced tumor growth.

PI_NAMEs: PERVIN, SHEHLA  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;African American;African American Women;Antibody Therapy;Antioxidants;BALB/c Nude Mouse;Behavior;Biomedical Research;Breast Cancer Cell;breast cancer progression;cancer cell;cancer diagnosis;cancer risk;cancer stem cell;Carcinogens;Caucasians;CCL22 gene;CD8B1 gene;Cell Physiology;Cells;chemokine;cigarette smoke;Cigarette Smoker;combustible cigarette;Complex;Computer Analysis;CXCL10 gene;Cysteine;Data;Death Rate;Development;Devices;Disease;DNA Damage;e-cigarette aerosols;e-cigarette smoke;Electronic cigarette;electronic cigarette use;embryonic stem cell;Ensure;Environmental Risk Factor;Epidemic;ethnic difference;Experimental Designs;experimental study;Exposure to;Flow Cytometry;Future;Genes;Genetic;genetic signature;Genomic Instability;Grant;Growth;Health;Health Hazards;Human;IL2RA gene;Immune;Immune Evasion;implantation;Inbred BALB C Mice;Injections;innovation;Institution;Long-Term Effects;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Marketing;MDA MB 231;MDA-MB-468;Mediating;Mediator;Medical Students;Molecular;Molecular Target;Monoclonal Antibodies;Mouse Mammary Tumor Virus;multiplex assay;Mus;neoplastic cell;NF-kappa B;Nicotine;nicotine exposure;nitrosative stress;Oxidative Stress;Oxidative Stress Induction;Oxides;Pathway interactions;pharmacologic;Poison;polyoma middle tumor antigen;Population;Predisposition;Prognosis;programs;Publishing;rapid growth;Reactive Oxygen Species;Regulatory T-Lymphocyte;Reporting;Research;Risk;Role;Saline;Signal Pathway;Signal Transduction;small hairpin RNA;student training;Superoxide Dismutase;Testing;Tissues;TNF gene;transcriptome sequencing;Transgenic Organisms;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;Tumor Weights;tumorigenesis;undergraduate student;United States National Institutes of Health;Up-Regulation;Woman;Xenograft Model;Xenograft procedure;Youth

PROJECT_TITLE: Electronic cigarettes, oxidative stress and development of breast tumor


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The Unfolded Protein Response is central to cellular health and forms a network of pathways that attempt to re-establish a healthy proteome. Using the PI’s expertise in quantitative, genome-scale technology, computational analysis, and targeted validation experiments, the proposed projects will investigate critical pathways in this network. It will investigate the connections between the Unfolded Protein Response, translation induction of key genes, and the role of a little known protein modification.

PI_NAMEs: VOGEL, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Amyotrophic Lateral Sclerosis;Binding Proteins;biological adaptation to stress;Cells;Cephalic;Complex;Computer Analysis;Critical Pathways;Disease;DNA Damage;DNA Repair;Elements;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;gain of function;Gene Expression Profiling;gene induction;Genes;Genetic Complementation Test;Genetic Transcription;genome-wide;Goals;Health;Initiator Codon;Link;Maintenance;Messenger RNA;MicroRNAs;misfolded protein;Molecular Profiling;Motor Neurons;multicatalytic endopeptidase complex;Nerve Degeneration;neuronal survival;Neurons;next generation;novel;Pathway interactions;Post-Translational Protein Processing;Process;Property;protein degradation;Protein Isoforms;Proteins;Proteome;proteostasis;Quality Control;RAD23B gene;Regulatory Element;Research;Resistance;Resources;response;Ribosomes;RNA Degradation;RNASE3L gene;Role;Scanning;Signaling Molecule;Spinal;Stress;System;Technology;Terminator Codon;tool;Transcript;transcription factor;Translational Regulation;Translations;Ubiquitin Like Proteins;Ubiquitination;Validation;Work

PROJECT_TITLE: Next generation gene expression analysis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This research project aims to identify methods to manipulate communication between fibro-adipogenic progenitors and the extracellular matrix in skeletal muscle fibrosis and identify the effect of subpopulations of these cells on fibrosis and regeneration. In the short term, this project will contribute to the understanding of the role fibro-adipogenic progenitors play in the development of fibrosis. In the long term, this work can be used to identify anti-fibrotic targets to stop the progression of fibrosis and improve muscle function.

PI_NAMEs: LOOMIS, TARYN  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Angiopoietins;Animals;antifibrotic treatment;Architecture;Behavior;Biopsy Specimen;Blood Vessels;Cell Adhesion Molecules;Cell Nucleus;Cell Separation;Cells;Chronic;Coculture Techniques;Collagen;Communication;Contracture;crosslink;Data;density;Deposition;Development;differential expression;Duchenne muscular dystrophy;Engineering;Environment;Extracellular Matrix;Extracellular Structure;Fibrosis;Goals;Heterogeneity;Human;Hydrogels;Impairment;improved;Individual;Injury;innovation;insight;mdx mouse;mechanical signal;Mechanics;mechanotransduction;Methods;Modeling;mouse model;Mus;Muscle;Muscle Cells;Muscle function;muscle progenitor cell;muscle regeneration;Myofibroblast;myogenesis;Myopathy;Natural regeneration;Nuclear Protein;Pathologic;Pattern;Phenotype;Play;progenitor;Proteins;receptor;regenerative;Research Project Grants;response;response to injury;Role;Sampling;Signal Pathway;Signal Transduction;Skeletal Muscle;small molecule inhibitor;Source;stem cell differentiation;stem cell fate;stem cell population;Structure;success;Symptoms;Testing;Therapeutic;therapeutic target;tool;transcription factor;Up-Regulation;Work

PROJECT_TITLE: Identifying the interactions between fibro-adipogenic progenitors and the extracellular matrix in skeletal muscle fibrosis


ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: PROJECT NARRATIVE  Microvesicles are small membrane enclosed sacs shed by all cells types and a growing body of evidence implicates these vesicles as a novel mode of intercellular signaling not only in normal physiology but also in several pathophysiological processes. However, we only have a rudimentary understanding about the cellular cues that drive their biogenesis and function. By investigating the composition of MVs, mechanisms involved in their release, interaction with target cells we expect to gain new insights into MV biology that in turn will inform new therapeutic strategies for diseases such as cancer, diabetes, neurodegenerative disease and cardiovascular disorders.

PI_NAMEs: D'SOUZA-SCHOREY, CRISLYN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Actomyosin;Address;ADP-ribosylation factor 6;Affect;Attention;Bacterial Infections;Biochemical;Biogenesis;Biological;Biology;Blood Vessels;Body Fluids;Cardiovascular Diseases;Catalogs;cell behavior;Cell Communication;Cell Line;Cell membrane;Cell surface;cell type;Cells;chemokine;Classification;Clinical;Communicable Diseases;Communication;Complex;CRISPR/Cas technology;Cues;cytokine;Diabetes Mellitus;Diagnostic;Discipline;Discipline of obstetrics;Disease;Endosomes;Endothelial Cells;Environment;exosome;experience;extracellular;extracellular vesicles;Fibrinogen;frontier;Functional disorder;Genetic Materials;Growth Factor;Guanosine Triphosphate Phosphohydrolases;in vivo;insight;intercellular communication;interest;Investigation;Knock-out;Ligands;Ligase;Link;Lipids;liquid biopsy;Liquid substance;Malignant Neoplasms;Mediating;Mediator;Membrane;microvesicles;Molecular;Morphogenesis;Nature;neoplastic cell;Neurodegenerative Disorders;novel;novel therapeutic intervention;Oncology;Onset of illness;Organism;Pathologic Processes;Pathway interactions;Phenotype;Physiological Processes;Physiology;Play;Population;Positioning Attribute;Process;Property;Proteins;Proteome;Publications;receptor;Recycling;release factor;Research;research and development;rho;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;stem;stem cell biology;Testing;trafficking;Vascular Endothelial Growth Factors;Vesicle;vesicular release

PROJECT_TITLE: New insights into extracellular signal transduction

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative – Overall We propose to establish a Center of Excellence for Addiction Studies (CEAS) that will offer core services allowing users to develop projects that will lead to new research in addiction sciences. The CEAS will focus on maladaptations of brain circuits linked to addiction through the activities of four Cores and a Pilot Research Project. The Cores and PRP will work closely to provide efficient services for users allowing the development of new insights into mechanisms and molecular targets relevant to addiction and relapse.

PI_NAMEs: PORRECA, FRANK  (contact);VANDERAH, TODD W

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;Acute Pain;addiction;Addictive Behavior;Address;Amygdaloid structure;Animals;Anxiety;Applications Grants;Area;Arizona;Basal Ganglia;base;Behavioral;Behavioral Assay;biological adaptation to stress;Biology;Brain;brain circuitry;Brain region;Cells;Chemicals;Cholecystokinin;chronic pain;Cognition;Cognitive;cognitive function;Collaborations;Complement;Corpus striatum structure;Corticotropin-Releasing Hormone;CRISPR/Cas technology;Data;detection method;Development;Disease;Dopamine;drug addiction therapy;drug of abuse;drug reinforcement;drug relapse;Dynorphins;Education;Elements;Endocannabinoids;Ensure;Evaluation;Event;Executive Dysfunction;executive function;Faculty;flexibility;frontal lobe;Funding;Future;Genes;Genetic;Genetic Techniques;Glutamates;Goals;Health Professional;Health Sciences;Impairment;Impulsive Behavior;Impulsivity;Individual;insight;kappa opioid receptors;Leadership;Learning;Letters;Link;Measurement;Measures;Mediator;Methods;millisecond;Modernization;Molecular;Molecular Target;motivated behavior;Motivation;Mus;National Institute of Drug Abuse;negative affect;Negative Reinforcements;neural;neural circuit;neurochemistry;Neurosciences;Neurotransmitters;New Mexico;novel strategies;Nucleus Accumbens;operation;Opioid;Opioid Antagonist;opioid epidemic;Opioid Peptide;opioid use;opioid withdrawal;optogenetics;Outcome;Outcome Measure;Pain;Pain Clinics;Pain management;Pain Research;Patients;Persistent pain;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Physicians;Pilot Projects;Population;Prefrontal Cortex;prevent;Process;Program Research Project Grants;Public Health;Rattus;recruit;Relapse;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Rewards;Science;Secure;Services;Signal Transduction;Specificity;Standardization;stem;Strategic Planning;Stress;Students;Substance abuse problem;Substance Addiction;System;Techniques;temporal measurement;Texas;therapy development;translational approach;treatment strategy;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;Withdrawal;Work

PROJECT_TITLE: The Center of Excellence in Addiction Studies (CEAS)


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PI_NAMEs: PORRECA, FRANK  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;animal care;Arizona;Award;Behavioral;Budgets;Categories;chemical safety;college;Communication;Communities;Data;Data Analyses;Data Collection;data repository;data sharing;Databases;Drug Addiction;drug relapse;Education;Ensure;Environment;Equipment;experimental study;Faculty;falls;Funding;Gene Targeting;Genetic;Goals;Grant;high standard;Human Resources;IACUC;insight;Institution;interest;Internships;lectures;Link;meetings;member;Methods;National Institute of Drug Abuse;neural circuit;Neurobiology;operation;outreach;Pain Research;Productivity;programs;Progress Reports;Protocols documentation;Public Health;Publications;Records;Regulation;Relapse;Reproducibility;Research;Research Personnel;Research Project Grants;response;Schedule;Scientist;Series;Services;success;summer internship;synergism;System;Technology;translational approach;Travel;treatment strategy;Underrepresented Populations;Universities;Update;Visit;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative The proposed methods will develop a PSMA-targeted therapeutic agent that combines chemotherapy and photodynamic therapy for the treatment of prostate cancer, optimize it in small animal models of prostate cancer, and then obtain toxicity and efficacy data in a large animal model, dogs. Dogs spontaneously develop prostate cancer that closely replicates the disease pathology and progression in humans. The agent is fluorescent as well as a therapeutic allowing for a theranostic approach in small animals that will decrease the time for molecule optimization; future clinical translation of the technology will have the potential to impact prostate cancer therapy.

PI_NAMEs: BASILION, JAMES PETER (contact);HOLT, DAVID ;WANG, XINNING

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Adverse event;Affinity;Androgens;Animal Model;Animals;Antibodies;Antibody-drug conjugates;Antigen Targeting;Antigens;Antineoplastic Agents;Binding;Biochemical;Biological Markers;cancer biomarkers;cancer cell;Cancer Etiology;cancer heterogeneity;cancer therapy;Canis familiaris;Carcinoma;Cell Death;cell killing;Cessation of life;Chemicals;Chemoresistance;chemotherapy;Clinical;clinical application;clinical efficacy;clinical translation;Clinical Trials;Collection;combat;Combination Drug Therapy;Combined Modality Therapy;companion animal;Complex;cost efficient;Cytotoxic agent;Data;design;Diagnosis;Disease;disorder risk;Dose;drug clearance;Drug Delivery Systems;drug development;drug efficacy;Drug resistance;Drug Synergism;Drug toxicity;Effectiveness;efficacy evaluation;efficacy study;efficacy trial;Exhibits;FOLH1 gene;Future;Generations;Genetic;Goals;Hematologic Neoplasms;high risk;Hormones;Human;human model;humanized antibody;Immune response;Immunocompetent;Immunologic Stimulation;Immunologics;Implant;improved;irradiation;Ligands;Light;Local Therapy;Localized Disease;Location;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane;men;Methodology;Methods;Microtubules;minimally invasive;Modification;Molecular Weight;mouse model;Movement;multimodality;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;overexpression;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Photosensitizing Agents;phthalocyanine;Physiology;prevent;Prodrugs;prostate cancer model;Prostate Cancer therapy;Prostate carcinoma;PUVA Photochemotherapy;Radiation therapy;Radical Prostatectomy;Reactive Oxygen Species;Recurrence;Refractory;refractory cancer;Relapse;Reporting;Resistance;response;Risk;screening;serum PSA;side effect;Site;small molecule;Solid Neoplasm;Structure of base of prostate;Systemic Therapy;systemic toxicity;targeted delivery;targeted imaging;targeted treatment;Technology;Testing;theranostics;Therapeutic;Therapeutic Effect;Time;Tissues;Toxic effect;Toxicology;translational therapeutics;Trastuzumab;treatment strategy;tumor;United States;virtual;Weight

PROJECT_TITLE: Highly selective targeted theranostics for prostate cancers

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Infections of bones by the bacterium Staphylococcus aureus cause a disease called osteomyelitis. Osteomyelitis is painful, difficult to treat, and is associated with bone loss. The goal of this project is to understand the mechanisms of bone loss and progression of infection in osteomyelitis. Knowledge to be gained from this project may lead to the implementation of better strategies to manage this disease.

PI_NAMEs: CASSAT, JAMES E;MBALAVIELE, GABRIEL ;VEIS, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Affect;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Architecture;Bacteria;bone;bone cell;Bone Diseases;bone loss;Bone Tissue;Cell Differentiation process;Cell Lineage;Cells;Chronic;Clinical;Complex;Data;Disease;Disease Management;Equilibrium;Event;Family member;Genetic;Goals;Hematogenous;Hematogenous Spread;Homeostasis;Host Defense;Hypoxia;Immune;immune clearance;Immune system;Immunity;Implant;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Interleukin-1;Interleukin-1 beta;Knowledge;Learning;Link;Macrophage;Methods;Microbial Biofilms;microorganism;Modeling;monocyte;mouse model;Multiprotein Complexes;Mus;Myelogenous;Myeloid Cells;Natural Immunity;neutrophil;Operative Surgical Procedures;Osteoblasts;Osteoclasts;Osteocytes;Osteomyelitis;Pain;pathogen;Pathogenesis;Pathologic;permissiveness;Population;Process;Proliferating;Public Health;Recurrence;Refractory;Regulation;Reporter;Resolution;response;Role;Route;Signal Transduction;skeletal;soft tissue;Source;Staphylococcus aureus;Staphylococcus aureus infection;success;Testing;Tissues;tool;Tumor necrosis factor receptor 11b;Work

PROJECT_TITLE: Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Gene Therapy;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: NAVRATILOVA, EDITA  (contact)

PROJECT_TERMS: addiction;Amygdaloid structure;Anatomy;Animal Experiments;Applications Grants;Area;Basal Ganglia;Behavioral;Brain;brain circuitry;Brain region;Cannabinoids;Capsid;cell type;Cells;Central Nervous System;Chronic;Collaborations;Complex;Corticotropin-Releasing Hormone;Cre driver;CRISPR/Cas technology;Data;design;designer receptors exclusively activated by designer drugs;Development;Dopamine;Drug usage;Drug user;Dynorphins;Endocannabinoids;Engineering;Ensure;executive function;Experimental Designs;Future;G-Protein-Coupled Receptors;Gene Deletion;Gene Delivery;gene editing technology;Gene Mutation;Gene Targeting;Genes;Genetic;genetic approach;Genetic Materials;Genetic Techniques;Genome;Glutamates;Goals;Habits;Halorhodopsins;Immunohistochemistry;Impairment;improved;in vivo;Individual;inducible gene expression;innovation;instrument;Investigation;Ion Channel;Knowledge;Light;Methodology;Methods;microbial;Microscopy;Modernization;Mus;National Institute of Drug Abuse;neural;neural circuit;neuromechanism;Neurons;neurotransmission;Neurotransmitters;Non-Viral Vector;Norepinephrine;novel;Opioid;Opioid Peptide;Opsin;optogenetics;Outcome;Outcome Measure;overexpression;Peripheral Nervous System;Pharmaceutical Preparations;pharmacologic;Phase;Plasmid Cloning Vector;Plasmids;Prefrontal Cortex;prevent;Prevention strategy;Property;Proteins;Protocols documentation;Rattus;Relapse;Reporter Genes;Reproducibility;Research;Research Personnel;Resources;restoration;Rewards;Rodent;Role;Serotonin;Services;Signal Pathway;Specificity;Standardization;Stress;Substance Use Disorder;substance use treatment;System;Techniques;Technology;tool;Transduction Gene;Transfection;transgene expression;Transgenes;Transgenic Mice;Transgenic Organisms;Viral;Viral Vector;Visualization;Withdrawal;Work

PROJECT_TITLE: Genetic Targeting Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed work will investigate the nature, extent and functional significance of dysregulated activity- dependent myelination resulting from absence seizures. Thus, this work will elucidate a novel pathogenic mechanism in pediatric epilepsy and potentially other neurological diseases. Future work will investigate maladaptive myelination in additional models of pediatric epilepsy as well as the underlying molecular mechanisms, which could be targeted in urgently needed disease-modifying therapies for children with epilepsy.

PI_NAMEs: KNOWLES, JULIET KLASING (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Absence Epilepsy;Acute;Affect;age related;Anterior;anterior commissure;Axon;Brain;Brain-Derived Neurotrophic Factor;Cell Proliferation;Child;Childhood;childhood epilepsy;Cognitive;comorbidity;Corpus Callosum;Data;Development;Diffusion;Disease;Electrocorticogram;Electroencephalography;Electron Microscopy;Epilepsy;epileptic encephalopathies;Ethosuximide;Exhibits;Frequencies;Future;Generalized Epilepsy;Generations;Hippocampus;Human;Image;in vivo;Inbred Strains Rats;indexing;inducible Cre;innovation;Internal Capsule;Investigation;Learning;Location;loss of function;loss of function mutation;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Methods;Modeling;Molecular;Molecular Target;Mus;Myelin;Myelin Sheath;myelination;Nature;Nervous System Disorder;network dysfunction;neural network;Neurons;neurophysiology;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;Pathogenicity;Pathologic;precursor cell;Predisposition;prevent;Process;Quality of life;Rattus;receptor;Recurrence;Research;Rodent;Rodent Model;Role;Sampling;SCN8A gene;Seizures;Signal Transduction;skills;Slice;Structural defect;Structure;Synaptic Potentials;Tamoxifen;Techniques;Thalamic structure;thalamocortical tract;Therapeutic;Thick;Time;Width;Work

PROJECT_TITLE: Maladaptive Myelination in Pediatric Epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Gastric cancer is the third most common cause of cancer-related death world-wide, causing more than 700,000 death each year. We plan to characterize novel molecular function(s) of AURKA in gastric carcinogenesis, in order to identify its biological, diagnostic, prognostic, and possibly therapeutic significance.

PI_NAMEs: EL-RIFAI, WAEL  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: 20q;Ablation;aurora kinase A;Biological;Biological Factors;Biology;Cancer Biology;Cancer Etiology;Cancer Model;Cancer Patient;carcinogenicity;Carcinogens;Catchment Area;Cells;Cellular Stress;Cessation of life;Chemoresistance;chemotherapy;Chronic;Clinical;Clinical Trials;clinically relevant;Comprehensive Cancer Center;Diagnosis;Diagnostic;docetaxel;Environment;Epithelial Cells;Etiology;Eukaryotic Initiation Factor-4E;evidence base;experience;fitness;Florida;functional outcomes;gastric carcinogenesis;gastric tumorigenesis;gastroesophageal cancer;Genes;Genetically Engineered Mouse;Helicobacter Infections;Helicobacter pylori;Human;human tissue;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;Infection;Intercept;LGR5 gene;malignant stomach neoplasm;Mediating;Molecular;mouse model;novel;Oncogenic;Oncology;Organoids;overexpression;Pathology;patient derived xenograft model;Population;preclinical study;prognostic;Property;protein expression;Proteins;Resistance;response;Rest;Risk Factors;Role;Sampling Studies;Signal Transduction;South America;Southeastern Asia;stem;Stomach Carcinoma;Survival Rate;Technology;Testing;Therapeutic;therapy resistant;Tissues;Translational Activation;translational study;Translations;Treatment Efficacy;treatment response;tumorigenesis;tumorigenic;United States;Universities;Work

PROJECT_TITLE: Intercepting novel functions of AURKA in gastric tumorigenesis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: PEDIATRICS

PHR: NARRATIVE Oxygen exposure in preterm babies increases systemic vascular stiffness that persists into adulthood, leading to hypertension, stroke and ischemic heart disease preterm born survivors. This proposal will investigate the molecular mechanisms that cause neonatal hyperoxia induced systemic vascular stiffness in preterm born survivors and the protective role of CXCR7 in preventing this vascular stiffness. These studies will demonstrate that endothelial CXCR7 activation is vasoprotective, and this has significant implications as it will have novel translational potential to prevent vascular stiffness in preterm born survivors across their lifespan.

PI_NAMEs: BENNY, MERLINE  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adult;Age Months;Agonist;Air;Aorta;Attenuated;Award;Biology;Biomechanics;Blood Vessels;Cardiology;Cardiovascular Physiology;Cardiovascular system;career;career development;CASP1 gene;CC chemokine receptor 7;Childhood;Culture Media;Data;Development Plans;Endothelial Cells;endothelial repair;Endothelium;experience;Exposure to;Fibrosis;Funding;Generations;genetic approach;Goals;Hares;Hour;Hypertension;Impairment;improved;In Vitro;in vivo;Incidence;Inflammasome;Inflammation;inhibitor;Injury;insight;Institution;Interleukin-1 beta;Intervention;Laboratories;laboratory experiment;Laboratory Research;Life;life span;Link;medical schools;meetings;Membrane;Mentors;Mentorship;Methodology;Molecular;Morbidity - disease rate;Myocardial Ischemia;Neonatal;neonatal care;Neonatal Hyperoxic Injury;Newborn Infant;novel;organ injury;Outcome;Oxygen;Pediatrics;Perinatal;pharmacologic;Phase;Placebos;Play;Positioning Attribute;pre-clinical;Premature Birth;Premature Infant;prevent;Prevention;Production;professor;profibrotic cytokine;Public Health;Rattus;receptor;Research;Rodent;Role;Signal Transduction;skills;Smooth Muscle Myocytes;Stroke;Survivors;Testing;Therapeutic;therapeutic development;Time;Training;Transforming Growth Factor beta;Translating;translational potential;Universities;Vascular Diseases;vascular inflammation;vascular injury;Vascular remodeling;Vascular Smooth Muscle;Work

PROJECT_TITLE: Protective role of CXCR7 in neonatal hyperoxia-induced systemic vascular dysfunction in adulthood

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: ESTERHAZY, DARIA  (contact);JABRI, BANA

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Allergic;allergic airway inflammation;Antigens;ATAC-seq;Autoimmune Diseases;Autoimmunity;Bioinformatics;Bone Marrow;candidate identification;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Color;CRISPR/Cas technology;cytokine;Dedications;design;Development;Enhancers;epigenetic marker;Epigenetic Process;Exposure to;Flow Cytometry;GATA3 gene;Gene Expression;Generations;Genetic;Genetic Models;genome-wide;Goals;Health;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Hypersensitivity;Immune response;in vivo;Infection;insight;Instruction;Liver;Lymphocyte;Lymphoid;Maps;microbial;Modeling;mouse model;Mus;mutant;Natural Killer Cells;Nature;novel;novel strategies;pathogen;Pathway interactions;Pattern;Phase;Population;programs;Property;Reporter;Reporting;Research;Resolution;response;Role;Salivary Glands;Specificity;System;T-Lymphocyte;Th2 Cells;Thymus Gland;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor;Uterus;Virus Diseases;ZNF145 gene

PROJECT_TITLE: Transcriptional Regulation of Innate-Like T Cells

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: HEIEN, MICHAEL L (contact)

PROJECT_TERMS: addiction;Anesthesia procedures;Animals;Behavioral;Biological;Biosensor;Brain;Brain region;carbon fiber;Cells;Chemicals;Communities;Corpus striatum structure;Coupled;Data Analyses;design;Detection;Dialysis procedure;Diffusion;Dimensions;Disease;Dopamine;dopamine transporter;dopaminergic neuron;Drug Addiction;Electrodes;emotional behavior;Exhibits;extracellular;Extracellular Space;flexibility;Functional disorder;Funding;Genetic Techniques;Heterogeneity;in vivo;instrument;interest;Interneurons;Investigation;kinetic model;Learning;Link;Measurement;Measures;Memory;Mental Depression;Mental disorders;Methodology;Methods;Microdialysis;Microelectrodes;Molecular;Monitor;Motivation;National Institute of Drug Abuse;Nervous System Disorder;neurochemistry;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;Neurotransmitters;Pacemakers;pain signal;Parkinson Disease;Pattern;Periodicity;pharmacologic;Phase;phase change;Physiological;Play;Preparation;protein function;Reaction Time;receptor;Research;Resolution;Role;Sampling;Scanning;Schizophrenia;sensor;Serotonergic System;Serotonin;Services;Signal Transduction;Site;Slice;spatiotemporal;Stimulus;Synapses;Synaptic plasticity;System;Techniques;Time;Tissues;Work

PROJECT_TITLE: Neuroanalytical Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PI_NAMEs: PANICKER, NIKHIL  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Adaptor Signaling Protein;Adult;Affinity;Age;age related;Aging;alpha synuclein;Alzheimer's Disease;Apoptosis;arm;Binding;Binding Proteins;Biological Assay;Biology;Biology of Aging;brain control;Brain Diseases;CASP1 gene;Caspase;Cells;Chronic;Clinical;Coculture Techniques;Complex;Conditioned Culture Media;cytokine;Data;Dementia;Dementia with Lewy Bodies;Disease Progression;Enzymes;Event;experimental study;Extracellular Space;Future;glial activation;Goals;Human;In Vitro;in vivo;Inflammasome;Innate Immune System;Integral Membrane Protein;Interleukin-1 beta;Knock-out;Knockout Mice;Laboratories;Lead;Lewy Bodies;Licensing;Ligase;Mediating;medical schools;Mentors;Mentorship;Microfluidics;Microglia;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neurotransmission;novel;Parkin;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Phase;Play;pre-formed fibril;prevent;Production;protein aggregation;protein misfolding cyclic amplification;Proteins;receptor;recruit;Role;screening;Series;Signal Transduction;symposium;synucleinopathy;System;Techniques;Toxic effect;Training;transmission blocking;transmission process;ubiquitin-protein ligase;Ubiquitination;Universities;uptake

PROJECT_TITLE: ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Lower respiratory tract infections, such as community-acquired pneumonia, represent a major cause of hospitalization and death worldwide. This project seeks to understand the long-term outcomes and heterogeneity of pneumonia due to an important tropical pathogen. The results of this proposal may help provide the basis for new treatments and management approaches to improve long-term outcomes in pneumonia.

PI_NAMEs: COSTON, TAYLOR DAVID (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Disease;acute infection;Admission activity;adverse outcome;Area;Automobile Driving;Award;Biological;biological heterogeneity;Biological Markers;burden of illness;Burkholderia pseudomallei;career;Categories;Cessation of life;Clinical;clinical heterogeneity;clinical translation;Cluster Analysis;community acquired pneumonia;community burden;comorbidity;Country;COVID-19 pandemic;Critical Care;cytokine;Data;Data Set;Development;Enrollment;Environment;Epidemiologic Methods;Ethics;Etiology;Faculty;follow-up;Funding;Future;Genetic Variation;global health;Goals;Gram-Negative Bacteria;Health;Heterogeneity;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;IL8 gene;Immune response;improved;individualized medicine;Infection;Inflammation;Inflammatory;insight;Integration Host Factors;Interleukin-6;K-Series Research Career Programs;Laboratories;longitudinal analysis;Longitudinal cohort;low and middle-income countries;Lower Respiratory Tract Infection;Lung;lung health;Mechanical ventilation;Mediating;Medicine;Mentorship;mortality;novel;Outcome;pathogen;Patient Admission;Patients;Physicians;Plasma;Pneumonia;Predisposition;Prevention;Prospective cohort;readmission rates;Recovery;Research;Research Personnel;Research Project Summaries;Research Training;Risk;Risk Factors;Sampling;Scientist;Severities;Severity of illness;Shock;skills;Subgroup;Survivors;targeted treatment;Techniques;Testing;Thailand;Therapeutic;TNF gene;Training;translational physician;Universities;Washington;Work

PROJECT_TITLE: Determinants of long-term outcomes and heterogeneity in Gram-negative community-acquired pneumonia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PI_NAMEs: MILNES, TALLY MARIE (contact)

PROJECT_TERMS: addiction;Address;Amalgam;Animal Model;Animals;Arizona;Attention;Behavior;Behavior assessment;Behavior Disorders;behavior measurement;behavior test;Behavioral;Behavioral Assay;behavioral outcome;Biogenic Amines;Bioinformatics;Biological Assay;Brain;Chronic;chronic pain;chronic pain patient;Classification;clinical diagnostics;clinical translation;clinically relevant;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;Collection;Communities;Complex;conditioned place preference;Coupling;Data;Database Management Systems;Decision Making;design;Detection;Diagnosis;diagnostic criteria;driving behavior;Drug abuse;Drug usage;DSM-V;effective therapy;Electronics;Emotional;emotional trauma;Evaluation;executive function;experimental study;Exposure to;Functional disorder;Gender;Genetic;genetic approach;genetic manipulation;Grooming;Human;Impaired cognition;Impairment;in vivo;insight;Intake;Intellectual impairment;International;Intervention;large datasets;Learning;learning strategy;Lipids;Machine Learning;Maintenance;Marble;Measurement;Measures;Mediating;Memory;Methodology;Microdialysis;Mission;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;National Institute of Drug Abuse;neglect;neural circuit;neural network;Neural Pathways;neurochemistry;Neuromodulator;Neuropharmacology;Neurotransmitters;novel;object recognition;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid misuse;opioid use;opioid use disorder;Pain;Pain Measurement;Pain Research;Pathology;Patients;Peer Review;Peptides;Perception;Performance;Persistent pain;Pharmaceutical Preparations;Pharmacology;pre-clinical;Pre-Clinical Model;Process;psychologic;Publications;Recording of previous events;Relapse;Reproducibility;Research;Research Personnel;Research Proposals;Rewards;Self Administration;Signal Transduction;social;Social Interaction;Speed;Standardization;substance misuse;Substance Use Disorder;Symptoms;synergism;System;Testing;Time;translational applications;translational potential;United States National Institutes of Health;Universities;welfare

PROJECT_TITLE: Behavioral Core


NIH_SPENDING_CATS: Wound Healing and Care

ORG_CITY: AMES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research seeks to use engineered cell environments to determine how cells make migration decisions when several pieces of contradictory information are presented, an important process during development, wound healing, and cancer. Much work has been carried out in understanding how cells directionally migrate in respond to single pro-migration cues, but very little is known about how cells integrate multiple directional cues. Understanding multi-cue sensing requires an engineering approach to generate tunable systems to identify potential drug targets for blocking multi-cue sensing in diseases such as cancer as well as enhance multi-cue sensing in wound healing.

PI_NAMEs: SCHNEIDER, IAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actinin;Adhesions;Alginates;Biological;Bundling;cancer cell;cell motility;cell type;Cells;chronic wound;Cicatrix;Collagen;Collagen Fiber;Collagen Fibril;Complex;Coupled;crosslink;Cues;Cytoskeleton;Decision Making;Dermal;design;Development;directional cell;Disease;drug candidate;drug discovery;Drug Targeting;Engineering;Environment;Extracellular Matrix;F-Actin;Fiber;Fibroblasts;flexibility;Gel;Goals;Growth;Immune;Immune response;imprint;In Vitro;in vivo;Individual;insight;Invaded;Lead;Malignant Neoplasms;mechanical properties;Mechanics;Mediating;Microtubules;migration;Molecular;Myosin Type II;Neoplasm Metastasis;next generation;Normal Cell;Pathologic;Pathologic Processes;Pathway interactions;Physiological;Physiological Processes;Play;predictive marker;preference;Process;Research;response;Role;self assembly;spatial integration;Structure;Sum;synergism;System;Testing;Therapeutic;Tissue Engineering;Tissues;transmission process;traumatic wound;tumor microenvironment;virtual;Work;wound bed;wound dressing;wound healing

PROJECT_TITLE: Cell Migration Control through Modulation of Multiple Directional Cues

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Patient Safety;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying and frequently associated with chronic nausea and vomiting, early satiety, and abdominal pain. Gastroparesis is a disease affecting predominantly young women which can have a devastating impact on quality of life. The GpCRC aims to transform scientific discoveries from laboratory, clinical, and population studies into clinical applications to improve treatments and reduce the burden of adverse outcomes due to gastroparesis.

PI_NAMEs: SHADE, DAVID M (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Adolescent;Adult;adverse outcome;Affect;Amendment;Ancillary Study;biobank;Biological Assay;Biometry;Biopsy;Buspirone;Catheters;Characteristics;Child;Childhood;Chronic;Clinic;Clinical;clinical application;clinical center;Clinical Data;clinical database;Clinical Management;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Code;Collaborations;Collection;Data;Data Analyses;data management;data repository;Databases;Development;Devices;Diagnosis;digital repositories;Disease;Disease Progression;Dyspepsia;early satiety;endophenotype;Equipment and supply inventories;Ethics;Etiology;FDA approved;Feces;follow-up;Funding;Future;Gastric Emptying;Gastric Tissue;Gastrointestinal Diseases;Gastroparesis;Genetic;genomic data;Guidelines;imaging probe;imaging study;Immune;improved;Incidence;Inflammatory Bowel Diseases;Institutional Review Boards;Investigational Drugs;Laboratory Study;Leadership;Maintenance;Manuscripts;Masks;Measures;meetings;Mission;Modeling;Modification;Molecular;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nausea and Vomiting;novel therapeutics;nutrition;Nutritional;Observational Study;Output;Participant;Pathogenesis;Pathologic;Patients;pediatric patients;Performance;Peripheral Blood Mononuclear Cell;Persons;Phase;phase II trial;Physiological;Placebo Control;Plasma;Policies;Population Study;Preparation;Private Sector;Procedures;programs;prospective;protocol development;Protocols documentation;psychologic;public repository;public-private partnership;Publications;Pyloric sphincter structure;quality assurance;Quality of life;Radionuclide Imaging;Randomized;Registries;Reporting;repository;Research;Research Design;Research Personnel;Resources;Risk;Safety;Sample Size;Satiation;Scientist;Sensory;Serum;Shipping;Specimen;Stomach;Symptoms;Syndrome;Testing;Therapeutic Trials;Thick;Time;timeline;treatment response;treatment trial;Urine;Water;Work;young woman

PROJECT_TITLE: Continuation of the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC) 4


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: Project Narrative The New York State Department of Health (NYSDOH) has been a leader in protecting and advancing the health of New Yorkers through a comprehensive network of public health activities and services. The complexity of the state, from densely populated urban, to rural and suburban areas, the diversity of the state with respect to race, ethnicity, and socioeconomic status, warrants a public health system that is comprehensive and flexible to govern the state’s public health successfully. To aid in the reduction of foodborne illness and prevalence of antibiotic resistance bacteria both locally and nationally the NYSDOH is seeking funding to improve detection of, and surveillance for, antibiotic resistant bacterial pathogens isolated from food products purchased from retail grocery stores

PI_NAMEs: MINGLE, LISA  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pain Research;Substance Misuse

PI_NAMEs: COWEN, STEPHEN LEIGH (contact)

PROJECT_TERMS: addiction;Advisory Committees;Anesthesia procedures;Animal Behavior;Animals;Arizona;Attention;awake;Behavior;Behavioral;behavioral study;Budgets;chronic pain;Cognitive;cognitive testing;Collection;Communication;Conflict of Interest;Core Facility;Corpus striatum structure;Cues;Data;Dedications;Development;Devices;Dopamine;Drug abuse;Drug Addiction;Electronic Mail;Emotional;executive function;Exhibits;experimental study;Exposure to;Extramural Activities;Feedback;flexibility;Fostering;Funding;Future;Genetic;Goals;Grant;Impairment;improved;Individual;innovation;interest;Learning;Letters;Measurement;meetings;Methodology;Methods;Molecular;Mus;National Institute of Drug Abuse;neural;neural circuit;Neural Inhibition;Neurology;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;new technology;novel strategies;Opioid;opioid exposure;optogenetics;Pain;pain reduction;Pharmaceutical Preparations;Pharmacology;Phase;Photometry;Physiological;Physiology;Pilot Projects;Play;programs;Psychology;Relapse;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;service utilization;Services;Substance abuse problem;Summary Reports;System;Technology;Testing;theories;United States National Institutes of Health;Universities;wasting;web site;wireless;Wireless Technology;Work;Writing

PROJECT_TITLE: Pilot Project Research Core


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA STATE DEPT OF HEALTH

ORG_STATE: PA

PHR: Pennsylvania Surveillance for Antimicrobial Resistant-enteric Bacteria in Retail Food Project Narrative Conducting surveillance for enteric bacteria in retail food as part of the National Antimicrobial Resistance Monitoring System (NARMS) provides critical data to the FDA necessary for regulatory oversight of antibiotic use in animals and humans. Comparison of bacterial isolates recovered from retail food (e.g., Salmonella) with strains causing human illnesses contributes to improvements in food safety, facilitates outbreak investigations, trace-back of contaminated products, and prioritization of interventions such as facility inspections by regulators.

PI_NAMEs: M'IKANATHA, NKUCHIA MUGAMBI (contact)


NIH_SPENDING_CATS: Brain Disorders;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Rett Syndrome;Sudden Infant Death Syndrome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE The central noradrenergic system is a key component of the brainstem respiratory network that maintains breathing homeostasis under a variety of conditions and protects against potentially lethal challenges. The proposed studies aim to determine the functional and mechanistic organization of the central noradrenergic system in protective respiratory reflexes that are hypothesized to be perturbed in congenital respiratory disorders such as Rett Syndrome and SIDS that are also associated with central noradrenergic (NA) abnormalities.

PI_NAMEs: RAY, RUSSELL S (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Adult;Area;Brain Stem;Breathing;Carbon Dioxide;Childhood;Chromosome Mapping;Compensation;congenital respiratory disorder;Data;design;Development;developmental disease;developmental genetics;Disease;DNA Sequence Alteration;Electrophysiology (science);Embryo;Etiology;Failure;Female;Functional disorder;Gene Mutation;Generations;Genetic;glutamatergic signaling;Glutamates;Goals;Grant;hindbrain;Homeostasis;in vivo;Infant;innovation;insight;Laboratories;Life;male;Maps;Measurement;Methyl-CpG-Binding Protein 2;Modeling;Molecular;mortality;mouse model;Mus;Neonatal Mortality;neonate;neural circuit;Neurodevelopmental Disorder;Neurons;Neurotransmitters;noradrenergic;Norepinephrine;novel;Outcome;Output;patch clamp;patch sequencing;Patients;Pattern;Play;Plethysmography;Population;postsynaptic;presynaptic;Production;public health relevance;Reflex action;Research;resilience;Respiration Disorders;respiratory;Respiratory physiology;respiratory reflex;Rett Syndrome;Role;Sensory;Signal Transduction;single-cell RNA sequencing;Sudden infant death syndrome;Syndrome;System;Techniques;Therapeutic;tool;transmission process;United States;Work

PROJECT_TITLE: Noradrenergic mechanisms in breathing and respiratory pathophysiologies

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The network in the brain that controls sleep and wakefulness is turned on during general anesthesia, but it is unknown how the brain can produce coma and sleep, two unconscious states that are similar but different, by turning on the similar brain network. This project will look at both the same and different parts of the brain network that are active during anesthesia and sleep by using state-of-art techniques that give exact information about each cell and compare two brain networks side by side. The proposed project is important for public health because it will lead to better clinical care for people who need unconsciousness as a treatment, including general anesthesia, sedation during procedures, and insomnia.

PI_NAMEs: IMAMURA, TOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Ablation;Acute;Address;Anesthesia procedures;Anesthetics;Arousal;Automobile Driving;Biological Assay;Brain;brain control;Brain Stem;cell type;Cells;clinical care;clinical practice;Coma;Data;Elements;gamma-Aminobutyric Acid;General Anesthesia;Genetic Recombination;Hypnosis;hypnotic;In Situ Hybridization;Isoflurane;Mediating;Narcolepsy;neural circuit;Neural Inhibition;neuromechanism;Neurons;non rapid eye movement;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Population;Procedures;Public Health;Resistance;Sedation procedure;sedative;Side;single nucleus RNA-sequencing;Sleep;Sleep Disorders;sleep regulation;Sleeplessness;System;Techniques;transcriptomics;Unconscious State;Wakefulness

PROJECT_TITLE: Anesthesia and Sleep: Mechanisms of Generating Two Similar Yet Distinct Unconscious States in the Medulla

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ALBANY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE Deregulation of calcium handling and mitochondrial function is implicated in most if not all neurodegenerative diseases as well as other age-related disease. Thus, the goal of the proposed research project is to resolve the molecular mechanisms underlying calcium regulation and mitochondrial function and, therefore, provide insight into the causes of and strategies to treat neurodegenerative disease.

PI_NAMEs: NORMAN, KENNETH R (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;age-related disease;Alzheimer's Disease;Behavioral Assay;Biological Assay;Biological Models;Caenorhabditis elegans;Calcium;Calcium Signaling;Cell Death;Cell division;Cell Physiology;cell type;Cells;Defect;Early Onset Familial Alzheimer's Disease;Endoplasmic Reticulum;fitness;Functional disorder;gene product;genetic manipulation;Genetic Transcription;Goals;Health;Heart Diseases;Homeostasis;Human;insight;live cell microscopy;Lysosomes;Mediating;Mediator;Meditation;Mitochondria;mitochondrial metabolism;Molecular;Muscle Contraction;Muscular Dystrophies;mutant;Mutation;Necrosis;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Orthologous Gene;Plants;presenilin;Process;Proteins;proteostasis;Regulation;Research Project Grants;Resolution;RNA interference screen;Role;Structure;Synaptic Vesicles;System;uptake;vesicular release

PROJECT_TITLE: Deciphering Molecular Mechanisms of Calcium Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE High Mobility Group Box 1 (HMGB1) protein is released by human cells to, in part, alert the host of damage by promotion of a strong inflammatory response, however when unchecked, excess HMGB1 can elicit dangerous sequelae. We have now discovered that HMGB1 can also disrupt the protective extracellular matrix of communities of bacterial pathogens (i.e. biofilms) that contribute significantly to the chronicity and recurrence of infection, and in doing so, render them vulnerable to the host immune system and antimicrobials. In this regard, we have identified the minimal region of HMGB1 that possesses therapeutic anti-biofilm activity without the counter-effective pro-inflammatory function and propose to further define the mechanism of action and breadth of its effectiveness to develop a novel host-directed therapeutic option for these recalcitrant infections to ideally be used in combination with treatments that are pathogen-directed in order to gain the greatest clinical outcome.

PI_NAMEs: GOODMAN, STEVEN D (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 3-Dimensional;acute infection;Affinity;Amino Acid Sequence;Amino Acids;Animal Model;Antibodies;antimicrobial;Architecture;Bacteria;bacterial community;Bacterial DNA;Bacterial Infections;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Biological Assay;Burkholderia cepacia;Cell Physiology;Cells;Chinchilla (genus);Chromatin;Chronic;chronic infection;Clinical;Communities;Cruciform DNA;Dangerousness;Deoxyribonucleases;Digestion;Disease;Dissection;DNA;DNA Binding;DNA metabolism;DNA Structure;DNA-Binding Proteins;effective therapy;Effectiveness;Elements;Equilibrium;Experimental Animal Model;extracellular;Extracellular Matrix;Extracellular Structure;Family;Genetic Recombination;Goals;HMGB1 gene;Human;human disease;human model;human pathogen;immune clearance;Immune response;Immune system;In Vitro;in vitro activity;in vivo;Infection;Inflammatory;Inflammatory Response;inhibitor;intercellular communication;large scale production;Lung infections;Maintenance;Mediating;Microbial Biofilms;mindfulness;Modeling;Molecular;mouse model;Nontypable Haemophilus influenza;novel;Otitis Media;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pattern;Permeability;Physiology;Play;Polymers;polymicrobial biofilm;preference;Process;Property;Proteins;Reaction;recurrent infection;repaired;Resistance;Resolution;Role;Sampling;scaffold;Sepsis;Specificity;Structure;Testing;Therapeutic;Therapeutic Agents;Treatment Efficacy;virtual;Work

PROJECT_TITLE: HMGB1-mediated host response to chronic bacterial infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Early life respiratory syncytial virus pulmonary infection is associated with the development of childhood wheeze and asthma. New data using a neonatal murine model of RSV infection has demonstrated that RSV infection can alter the early life gut microbiome and predispose an individual for enhanced allergic disease. The goal of this project is to understand how an alteration of the microbiome may alter the immune cell precursors leading to enhanced allergic responses while also further developing a pre-doctoral candidate with interdisciplinary training in immunology and bioinformatics.

PI_NAMEs: ETHRIDGE, ALEXANDER DALE (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;Airway Disease;airway hyperresponsiveness;Allergens;Allergic;Allergic Disease;Allergic inflammation;allergic response;Antigen-Presenting Cells;Area;Asthma;Bacterial DNA;Bioinformatics;Bone Marrow;Bronchiolitis;Cell Differentiation process;Cell Physiology;Cells;Child;Childhood;Childhood Asthma;ChIP-seq;Chromatin;chromatin modification;Chromatin Structure;Circulation;Climacteric;Clinical;cockroach allergen;Critical Thinking;cytokine;Data;Dendritic Cells;Development;dietary;disease phenotype;Emigrations;Environment;epidemiology study;Epigenetic Process;epigenetic regulation;Event;experimental study;Germ-Free;Gnotobiotic;Goals;Goblet Cells;gut microbiome;gut microbiota;Hematopoiesis;histone modification;Hospitalization;Hypersensitivity;Hypertrophy;Immune;Immune response;Immune system;Immunity;Immunology;immunopathology;immunoregulation;Incidence;Individual;Infant;infant infection;Infection;Inflammation;Inflammatory;innate immune mechanisms;Innate Immune Response;Innate Immune System;insight;Laboratories;Life;Link;Literature;Location;Lung;Lung Diseases;Lung infections;Macrophage;Metabolism;microbial;microbiome;microbiome alteration;microbiome signature;microbiota;microbiota composition;migration;Modeling;Modification;Monitor;monocyte;mouse model;Mucosal Immune System;mucosal site;Mucous body substance;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Nature;Neonatal;neonatal mice;neonatal respiration;neonate;novel;Onset of illness;Pathogenicity;Pathologic;Population;pre-doctoral;precursor cell;Predisposition;Production;Published Comment;Publishing;pulmonary function;Relative Risks;Research;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Role;Scientist;Sentinel;Shapes;skills;Stimulus;Structure;Testing;Tissues;Training;transcriptomics;Wheezing;Work

PROJECT_TITLE: Early Life Pulmonary Infection, Microbiome and Trained Innate Immunity


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Traumatic brain injury is a debilitating disorder that affects 70 million people worldwide every year but has no treatment. The goal of this proposal is to systematically map the input-output connections to excitatory hippocampal neurons after brain injury and track the progressive in vivo functional changes in neuron activity over time.

PI_NAMEs: TIERNO, ALEXA MARIE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;Affect;Anatomy;Animals;Area;Award;basal forebrain;Behavior;Brain;Brain Injuries;Brain region;Calcium;career;Cell Culture Techniques;cell type;Cells;Cessation of life;Chronic;Code;cognitive disability;Communities;Complement;Complex;Computer Analysis;Deafferentation procedure;Dedications;Disease;Embryo;entorhinal cortex;Epilepsy;Evaluation;excitatory neuron;experimental study;fluid percussion injury;Functional disorder;gamma-Aminobutyric Acid;Germ Cells;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Image;Impairment;in vivo;in vivo calcium imaging;induced pluripotent stem cell;inhibitory neuron;injured;Injury;Institution;International;Interneurons;Knowledge;Laboratories;Lateral;Learning;Light;Literature;Maintenance;Maps;Medial;Memory;Mentorship;Microscope;migration;mouse model;Mus;Nervous System Trauma;neural circuit;Neuroanatomy;Neurobiology;Neurons;neurophysiology;Neurophysiology - biologic function;Neurosciences;novel;Output;Persons;Physiology;place fields;postsynaptic;Pre-Clinical Model;Precision therapeutics;presynaptic;prevent;progenitor;Property;Publishing;Rattus;Recurrence;Reporting;Research;Research Personnel;response;Risk;Rodent;Rodent Model;Role;Scientist;Seizures;spinal cord and brain injury;stem cells;Synapses;TBI treatment;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;Translating;Transplantation;Traumatic Brain Injury;Viral;Visualization;Vocational Guidance;Work

PROJECT_TITLE: Imaging progressive circuit reorganization after traumatic brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: NARRATIVE Drug resistance threatens to upend progress in tuberculosis control. Two of the most promising strategies to limit the emergence of drug resistance are the targeting of non-replicating, drug-tolerant Mycobacterium tuberculosis (Mtb) and host-directed therapy. Here, we explore both through unique inhibitors that combine both mechanisms in the same compound. This project will identify new drug tolerance-associated targets in Mtb, explore a new immune factor that controls tuberculosis, and explore the in vivo efficacy of our dually active inhibitors.

PI_NAMEs: GRUNDNER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;analog;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimycobacterial Agents;Area;Bacteria;Biological Availability;Cause of Death;cell type;cellular targeting;Cessation of life;Chemicals;Clinical;Combined Antibiotics;Communicable Diseases;Confocal Microscopy;Data;drug efficacy;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Drug Targeting;Drug Tolerance;efficacy testing;emerging antibiotic resistance;Extreme drug resistant tuberculosis;Flow Cytometry;Genetic;genetic approach;genome sequencing;Growth Factor Receptors;Human;Immune;Immune response;Immunologic Factors;Impairment;improved;in vitro activity;in vivo;in vivo evaluation;Infection;Inflammation;inhibitor;Integration Host Factors;Interferon Type II;Lung;Macrophage;Mediating;Molecular;Molecular Target;mouse model;Multidrug-Resistant Tuberculosis;Mus;mutant;Mycobacterium tuberculosis;novel;novel therapeutics;Oral;Outcome;pathogen;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Population;prevent;Proteomics;Receptor Inhibition;Receptor Signaling;Recommendation;Resistance;resistance mechanism;resistant strain;Rifampin;Role;Series;Side;Signal Transduction;Site;T cell response;T-Lymphocyte;targeted treatment;Testing;therapy duration;tool;Transforming Growth Factor beta;Transforming Growth Factors;Tuberculosis;tuberculosis drugs;tuberculosis immunity;tuberculosis treatment;Validation

PROJECT_TITLE: Dual Targeting of Mtb Resistance Mechanisms


NIH_SPENDING_CATS: Congenital Structural Anomalies;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Pediatric;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Congenital malformations of external genitalia are among the most common birth defects in humans, affecting ~1:150 live male births in the US. Correction can require multiple surgeries, and high complication rates are associated with tissue deficiencies and poor differentiation. This project will use single cell RNA sequencing to produce spatial and temporal atlases of the diversity of cell types in male and female mouse external genitalia. We will genetically decouple hormonally- and genetically-regulated sex differences. Nanoscale 3D imaging and single molecule visualization of RNAs will identify anchor genes for specific cell types and will map them back to embryonic tissues.

PI_NAMEs: COHN, MARTIN J (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Affect;ambiguous genitalia;Anatomy;Androgens;Animal Model;Appearance;Atlases;Back;Birth;Buffers;cell type;Cells;Clitoris;Complication;computerized tools;Congenital Abnormality;Data;Defect;Development;Disease;Embryo;embryo tissue;Endocrine Disruptors;Environmental Risk Factor;epidemiologic data;epigenomics;Estrogens;external genitalia;Failure;Female;fetal;Folic Acid;Four Core Genotypes;gene function;Genes;Genetic;Genetic Models;Genitalia;Genitourinary system;Goals;Gonadal Steroid Hormones;Growth;Hormonal;Hormones;Human;Hypospadias;imaging approach;imaging modality;improved;In Situ Hybridization;Incidence;innovation;innovative technologies;Knowledge;Link;Location;male;Male Genital Organs;Maps;Mediating;Metals;Methods;Molecular;mouse model;Mus;nanoscale;Neural Tube Defects;novel;Operative Surgical Procedures;Organ;penis;Prevalence;prevent;Prevention;Prevention strategy;reconstruction;Reporting;RNA;Role;sex;Sex Chromosomes;Sex Differences;Sex Differentiation;sexual dimorphism;Side;single cell ATAC-seq;single molecule;single-cell RNA sequencing;Specific qualifier value;Structure;surgery outcome;Three-Dimensional Imaging;Tissues;Transcriptional Regulation;transcriptomics;Transgenic Organisms;Treatment outcome;Tube;Urethra;Validation;virtual;Visualization;XX male;XY females

PROJECT_TITLE: Diversification of cell types during male and female external genital development


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Health Effects of Indoor Air Pollution;Nanotechnology;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  The Southern California Superfund Research Program (SCSRP) will develop a modern and multidisciplinary training program for students and the community of industrial hygienists, and to prepare next-generation professionals for effective management of stressors caused by emerging technologies such as nanotechnology.

PI_NAMEs: TSAI, CANDACE SUJUNG  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: academic program;Air;American;Animals;Augmented Reality;Biological;Black, Indigenous, People of Color;California;Categories;Collaborations;Communities;community partners;Continuing Education;curriculum development;design;Discipline;doctoral student;E-learning;Education;education research;Educational Curriculum;Educational workshop;Electronics;Emerging Technologies;Engineering;Environment;Environmental and Occupational Exposure;Environmental Health;Environmental Impact;Environmental Pollution;Environmental Science;experience;exposed human population;Exposure to;Faculty;falls;Future;Generations;graduate school;graduate student;graphene;Guidelines;hands-on learning;hazard;Health;Health Professional;Human;Immigrant;in vitro Bioassay;Industrial Health;Industrialization;Industry;Infectious Agent;Influentials;Interdisciplinary Study;interest;Knowledge;laboratory experience;Leadership;Learning;Los Angeles;materials science;member;method development;Methods;migration;Mission;Modernization;multidisciplinary;nanoelectronics;nanoengineering;nanomaterials;nanoparticle;nanoscale;Nanotechnology;next generation;Occupational;Occupational Exposure;Occupational Health;Outcome;Participant;particle;Pathway interactions;physical science;Play;Policies;Population;population health;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;prevent;Process;programs;Public Health;Quantum Dots;recruit;Research;Research Activity;Research Project Grants;response;Risk;Role;Sampling;Scientist;Series;skill acquisition;social media;stressor;student mentoring;student training;Students;Superfund;System;Technical Expertise;Techniques;Technology;tool;Toxicology;Training;Training Activity;Training and Education;training opportunity;Training Programs;training project;transmission process;undergraduate student;United States;Universal Precautions;Universities;ventilation;Viral;viral nanoparticle;wasting;Work;workforce needs

PROJECT_TITLE: Occupational and Environmental Exposures and Work Practices for Nanomaterials and Electronic Products


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BILLINGS

ORG_NAME: MONTANA CANCER CONSORTIUM

ORG_STATE: MT

PHR: PROJECT NARRATIVE Montana Cancer Consortium exists to maximize access to clinical trials and research through centralized services and support for member physicians and affiliate sites that might not otherwise offer access to these critical opportunities. The uniquely rural and medically underserved population of Montana, Northern Idaho and Northern Wyoming offers stimulating challenges for implementing NCI-sponsored clinical trials and care delivery research. The collective experience of the affiliate sites in successful clinical trial enrollment and care delivery research in the vastly rural area will benefit NCORP's diversity and disparity goals.

PI_NAMEs: JEFFREY , ALLEN WARREN;SCHALLENKAMP, JOHN M. (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Address;Adult;American Indian Population;Area;Articulation;base;Board Certification;cancer care;Cancer Center;Cancer Hospital;cancer prevention;Cancer Survivorship;cancer therapy;care delivery;Caring;Clinical;clinical care;clinical practice;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;collaborative approach;Communication;Communities;Community Clinical Oncology Program;Dedications;design;Development;Disparity;Early Diagnosis;Education;Enrollment;experience;follow-up;Funding;Geography;Goals;Gynecologic Oncologist;Health Service Area;Health Services Accessibility;Home;Idaho;improved;Indian reservation;innovation;Knowledge;Leadership;Malignant Neoplasms;Medical;Medical Oncologist;medical specialties;medically underserved population;member;Mentors;Mission;Monitor;Montana;National Cancer Institute;Nonprofit Organizations;Oncology;oncology program;outreach;Participant;Patients;Physicians;Poverty;Prevention;primary care provider;Procedures;programs;Radiation Oncologist;Research;research facility;Research Personnel;Resources;response;Rural;rural area;rural dwellers;rural environment;Rural Population;rural underserved;rurality;screening;Services;Site;Speed;Surgeon;Taboo;Time;Training;Universities;Vision;Work;Wyoming

PROJECT_TITLE: Montana Cancer Consortium: An Inclusive and Collaborative Approach to Clinical Trial Accrual and Cancer Care Delivery Research across Montana, Idaho and Wyoming


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Synthetic hydrogels are attractive as cell culture scaffolds, but the challenge with their use lies in the lack of complexity as compared to biological systems, which translates to a lack of efficacy in the clinic. Hence, the goal of this proposal, and of our research lab, is to expand the toolbox for building complexity and functionality into synthetic hydrogel biomaterials by using dynamic chemistries and monomer sequence-based strategies. We envision broad applications in regenerative medicine, therapeutic delivery, and preclinical models of tissue for drug development, as well as fundamental studies that shed insight to the biological processes underlying cell- matrix interactions.

PI_NAMEs: ROSALES, ADRIANNE  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Amino Acids;Area;Award;Base Sequence;Biocompatible Materials;Biological Process;Biological Products;biological systems;Breathing;Cell Culture Techniques;Cells;Characteristics;Chemicals;Chemistry;Clinic;Clinical;commercial application;crosslink;design;Drug Delivery Systems;drug development;Engineering;Extracellular Matrix;Goals;Hydrogels;insight;interest;Marketing;Mechanics;monomer;Nature;Nucleotides;Permeability;Polymers;Pre-Clinical Model;Property;Proteins;Reaction;Regenerative Medicine;Research;Research Personnel;scaffold;self assembly;Structure;success;Therapeutic;Thinking;Time;timeline;Tissue Engineering;Tissue Model;Translating;Work

PROJECT_TITLE: Expanding the Functionality of Engineered Extracellular Matrices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT)  The formation of the 100S ribosome is a universal hallmark of both beneficial and pathogenic bacteria and is important for long-term cell survival. Completion of this study may offer insights for developing novel treatments and preventive interventions for infections and for improving the shelf life of current probiotics.

PI_NAMEs: YAP, M.-N. FRANCES (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;antimicrobial;Area;Bacteria;bacterial genetics;Binding;Biochemistry;Biogenesis;Biological;Catalysis;cell growth;Cell Survival;Cells;chronic infection;combat;Comparative Study;Complex;Cytoplasmic Protein;Data;Development;Dimerization;endonuclease;Endoribonucleases;Escherichia coli;Eukaryota;Exonuclease;Exoribonucleases;Firmicutes;Genetic Screening;genome-wide;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;Guanosine Triphosphate;Heterogeneity;Hibernation;Homologous Gene;human pathogen;Hydrolysis;improved;in vivo;Infection;innovation;insight;interdisciplinary approach;Intervention;Knock-out;Knowledge;Life;life span;Link;Location;Mass Spectrum Analysis;Messenger RNA;Metabolic;microscopic imaging;Microscopy;Modeling;Molecular;Mutagenesis;mutant;novel;Organism;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptide Elongation Factor G;Phase;Phenotype;Phosphodiesterase I;Positioning Attribute;Post-Translational Protein Processing;preservation;prevent;preventive intervention;Probiotics;Process;Proteins;public health relevance;Quality Control;rapid growth;Regulation;Resolution;Resources;ribonuclease R;Ribonucleases;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;Role;segregation;Site;small molecule inhibitor;spatiotemporal;Staphylococcus aureus;structural biology;Structure;superresolution microscopy;Time;Transcription Process;Translating;translation factor;Translation Initiation;Translation Process;Translational Derepression;Translations;unpublished works;Virulence;Virulence Factors;Work

PROJECT_TITLE: Regulation and function of bacterial hibernating 100S ribosome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Pain Research;Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: LA JOLLA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Low back pain (LBP) is a condition that affects a majority of the US population and has a high incidence of recurrent and persistent symptoms. Exercise-based rehabilitation and pharmacological management in the form of analgesic medications are often the first line of treatment in individuals with chronic LBP, however the interaction between these two treatment modalities is unknown. Here, we will compare medication usage patterns, exercise performance, and clinical outcomes in patients undergoing exercise-based rehabilitation that are taking different analgesic medications in an attempt to identify the interaction between medication and responsiveness of muscle to exercise in individuals with chronic LBP.

PI_NAMEs: SHAHIDI, BAHAR  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Analgesics;Animals;Atrophic;Back;Belief;Benzodiazepines;Blood;Central Nervous System;Chronic;Chronic low back pain;Clinical;Clinical Practice Guideline;Complex;cost;Diagnosis;disability;Dose;Drug Addiction;Drug Prescriptions;Exercise;exercise prescription;exercise program;exercise rehabilitation;Exercise Tolerance;exercise training;experience;Exposure to;Fright;General Population;Goals;health management;Human;Hypertrophy;Impairment;improved;Incidence;Individual;Infiltration;inhibitor;innovation;insight;Knowledge;Literature;Long term disability;Low Back Pain;Measures;Medication Management;Metabolism;Mitochondria;Modality;Muscle;Muscle Cells;muscle hypertrophy;muscle progenitor cell;Muscle Proteins;Muscle relaxants;Musculoskeletal;neurophysiology;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opioid;Outcome;Pain;pain reduction;pain relief;Participant;Pathologic;Patients;Pattern;Performance;persistent symptom;Pharmaceutical Preparations;Population;precision medicine;Prevention;Prognosis;programs;Protein Biosynthesis;psychosocial;Psychosocial Factor;Recommendation;Recovery;Recurrence;rehabilitation management;Rehabilitation therapy;Reporting;resistance exercise;Resolution;response;Risk;Slipped Disk;Spinal;standard of care;stem cell function;Symptoms;Time;Torque;Training Programs;treatment strategy;United States;Vertebral column;Work

PROJECT_TITLE: The interaction between analgesic medication and exercise-induced musclehypertrophy in patients with low back pain

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]