ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Protein methyltransferases (PMTs) are important enzymes that regulate epigenetics, translation, metabolism, and other fundamental biological pathways that are associated with critical diseased states. Dissecting the mechanism, regulation, and consequence of PMT activities is the key to understanding methylation-mediated disease processes, and meanwhile designing potent and selective drug molecules to target dysregulated PMTs is of immense demand in new therapy development.

PI_NAMEs: ZHENG, Y. GEORGE  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acetylation;Arginine;Biological;Biological Process;Biology;Cell Physiology;Chemicals;Coupled;design;Development;Diabetes Mellitus;Disease;Disease Pathway;drug discovery;Enzymes;Epigenetic Process;experimental study;Genetic Transcription;Goals;histone modification;human disease;Infection;Inflammation;innovation;Investments;Laboratory Research;Lysine;Malignant Neoplasms;Mediating;member;Metabolic Pathway;Metabolism;Methods;Methylation;Methyltransferase;Molecular;Molecular Target;Mutate;Nervous System Disorder;novel;novel therapeutics;Organism;overexpression;pathogen;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Physiology;Post-Translational Protein Processing;Process;programs;protein function;Protein Isoforms;Protein Methylation;Protein Methyltransferases;Protein-Arginine N-Methyltransferase;Regulation;Research;RNA Splicing;Signal Transduction;Structure;targeted treatment;therapeutic candidate;therapy development;tool;Translating;Translations

PROJECT_TITLE: Mechanism and Inhibition of Histone Modifications

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: We hypothesize that PDACs with an immunogenic profile could be a target subgroup that is responsive to immunotherapy either by MSLN-VLP vaccination or combination therapy of VLPs and an immune checkpoint inhibitor. We will test our hypothesis in pre-clinical animal models that best recapitulate human PDAC patient’s response to immunotherapy, including PDX and humanized mouse models. We propose two specific aims. In Aim 1, we will determine whether the immunogenic subtype of PDAC is responsive to MSLN-VLP vaccine in PDX-hu- NSG model. Here, we will use EDec method to stratify VA PDACs by subtype and then determine MSLN-VLP vaccine efficacy in specific PDAC subgroups in humanized PDX mouse model. In Aim 2, we will determine whether combination therapy with anti-PD-1 Ab enhances MSLN VLP vaccine responses and efficacy in onco-humice model.

PI_NAMEs: YAO, QIZHI C. (contact)

PROJECT_TERMS: Animal Model;anti-PD1 antibodies;Biological Markers;cancer cell;cancer immunotherapeutics;cancer immunotherapy;cell type;Cells;Classification;cohort;Combined Modality Therapy;Complex;Data;Databases;effective therapy;efficacy evaluation;Epigenetic Process;epigenomics;falls;FOXP3 gene;Gene Expression;General Population;genome sequencing;Genomics;Heterogeneity;Human;humanized mouse;Immune;Immune checkpoint inhibitor;immunogenic;Immunotherapy;improved outcome;Individual;infancy;Infiltration;innovation;Malignant neoplasm of pancreas;Malignant Neoplasms;mesothelin;Methods;Modeling;Molecular;mouse model;nano-string;Nature;novel;Pancreatic Ductal Adenocarcinoma;patient response;patient stratification;Patients;Pattern;personalized immunotherapy;pre-clinical;preclinical evaluation;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Sampling;side effect;specific biomarkers;Specimen;Stratification;Subgroup;System;Testing;The Cancer Genome Atlas;therapeutic evaluation;Tissues;treatment response;tumor;Tumor Subtype;tumor xenograft;tumor-immune system interactions;Vaccination;vaccine efficacy;vaccine response;Vaccines;Variant;Veterans;Virus-like particle;whole genome

PROJECT_TITLE: Stratification of Pancreatic Cancer Subpopulations for Effective Immunotherapy


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative:  Obesity, which is defined as an excessive accumulation of fat mass, is currently one of the leading public health challenges. Obesity is a legitimate public health concern for two reasons: 1) several other diseases are associated with obesity, including diabetes, cardiovascular disease and cancer, and 2) the rates of obesity have increased rapidly over the last forty years with almost one third of the adult population in the U.S. being classified as obese today. The goalof this proposal is to identify signals within fat that regulate fat mass and function,which may lead to the development of novel therapies for the treatment ofobesity and obesity-related pathologies.

PI_NAMEs: RODEHEFFER, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Aromatase;Biology;Cardiovascular Diseases;Cardiovascular system;Classification;Data;Development;Diabetes Mellitus;Disease;Endothelial Cells;Endothelium;Estrogen decline;Estrogens;Estrone sulfotransferase;Fatty acid glycerol esters;Female;Glucocorticoid Receptor;Glucocorticoids;Gonadal Steroid Hormones;Hyperplasia;hypothalamic-pituitary-adrenal axis;Imaging Techniques;Inflammatory;Knockout Mice;Link;lipid biosynthesis;male;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modeling;Molecular;multiplexed imaging;Mus;novel therapeutics;Obesity;Obesity associated disease;obesity development;obesogenic;Ovariectomy;Pathology;Pathway interactions;Pattern;Play;Population;Process;Production;Public Health;Receptor Signaling;Regulation;response;Role;sex;Signal Transduction;single-cell RNA sequencing;subcutaneous;Visceral;Visceral fat;Work

PROJECT_TITLE: Defining the role of an endothelial-adipocyte precursor axis in adipocyte hyperplasia

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Synthetic efficiency is critical to future advances in biology and medicine. Thus, the objective of this research program is to develop new technologies that provide effective solutions for the synthesis of difficult to access or inefficiently prepared biologically relevant compounds. The expected outcome of our program of research are the introduction of new methods based on multifaceted organoboron reagents that leverage their unique chemical attributes to enable novel, stereoselective approaches to such compounds from readily available starting materials.

PI_NAMEs: MEEK, SIMON JOHN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: 3-Dimensional;Alcohols;Amines;Attributes of Chemicals;base;Biological;biological preparation;Biology;Biomedical Research;Boron;Carbon;Catalysis;Chemicals;Complex;Development;drug discovery;Funding;Future;Generations;Goals;Grant;interest;Medicine;Metals;method development;Methods;Molecular;National Institute of General Medical Sciences;new technology;novel;novel therapeutics;Organic Synthesis;Outcome;Preparation;Process;programs;Reaction;Reagent;Research;scaffold;Structure;Therapeutic Agents;Transition Elements;Variant;Work

PROJECT_TITLE: New Organoboron based Methods and Strategies for Organic Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BLOOMINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE / PROJECT NARRATIVE The proposed research is relevant to public health because it addresses uneven implementation of evidence based cardiovascular disease (CVD) prevention guidelines that would prevent more than 50% of annual deaths in middle-aged US adults. Urgent expansion of telehealth due to the COVID-19 pandemic brings rapid changes in primary care visit patterns, posing new barriers to already uneven implementation and making intensive expert-led tailoring of strategies to local barriers even less feasible in practice. This proposal proposes an alternative design adapted from engineering to develop and pilot a configurable toolkit that can potentially increase guideline adherence through selection of implementation strategies matched to local barriers.

PI_NAMEs: RAMLY, EDMOND  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Adapting Guideline Implementation to Local Environments (AGILE) in Primary Care After Telehealth Expansion

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed studies are focused on how Factor IIIA produced by mast cells can protect against Group B Streptococcus (GBS) infections and the role of GBS proteins in Factor IIIA mediated entrapment. Our studies will also evaluate how sexual dimorphism in mast cells may favor an immune system that functions to enhance innate immune defense against GBS. These results will be relevant for prevention of bacterial infections and host defense.

PI_NAMEs: PILIPONSKY, ADRIAN M (contact);RAJAGOPAL, LAKSHMI

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adult;adverse birth outcomes;adverse outcome;adverse pregnancy outcome;Androgenization;Androgens;Anti-Bacterial Agents;Bacterial Infections;Binding Proteins;Blood Coagulation Factor;Bone Marrow;Cell Physiology;Cells;Coagulation Process;Complex;crosslink;Data;Development;diabetic;Disease;Elderly;Exhibits;Exposure to;Factor XIIIa;Female;Fetal Death;Fibrin;Fibronectins;Foundations;Future;Glutaminase;Goals;Gonadal Steroid Hormones;Gram-Positive Bacteria;granule cell;Host Defense;Human;Immobilization;Immune;immune system function;Immunocompromised Host;in utero;In Vitro;in vivo;Infection;inhibitor;innate immune mechanisms;male;mast cell;Mediating;Mediator;Membrane Proteins;Modeling;Morbidity - disease rate;Mus;Natural Immunity;neonatal infection;neonate;novel;pathogen;Perinatal;Play;Predisposition;Pregnancy;pregnant;Premature Birth;prenatal;prevent;Prevention;Process;Production;progenitor;Proto-Oncogene Protein c-kit;release factor;Reporting;response;Role;sexual dimorphism;stillbirth;Stimulus;Streptococcal Infections;Streptococcus CAMP protein;Streptococcus Group B;Systemic infection;Testing;Therapeutic;trafficking;Umbilical Cord Blood

PROJECT_TITLE: FXIIIA production by mast cells for innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(02)M]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The objective of this training program is to increase the number of Tanzania physician scientists with rigorous training in patient-oriented HIV clinical investigation. Mwanza Intervention Trials Unit (MITU) and Weill Bugando will establish courses in clinical investigation, advanced biostatistics, and epidemiology to be offered in Mwanza and 15 long-term trainees will conduct mentored research in one of the following HIV research priority areas: HIV prevention and vaccine research, implementation of HIV testing and treatment, women’s health, and management of HIV related opportunistic infections and cardiovascular disease. The goal is to establish MITU/Weill Bugando as a training hub for HIV clinical investigation in East Africa.

PI_NAMEs: FITZGERALD, DANIEL W (contact);KAPIGA, SAIDI

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Africa;AIDS prevention;Appointment;Area;Behavioral Research;Cardiovascular Diseases;Caring;clinical investigation;Clinical Investigator;Clinical Trials;co-infection;Collaborations;Disease;Doctor of Pharmacy;Doctor of Philosophy;epidemiology study;Funding;Goals;HIV;HIV Infections;Human immunodeficiency virus test;Hygiene;improved;individual patient;Institution;institutional capacity;Intervention Studies;Intervention Trial;Investigation;London;Medical Research;medical schools;Outcome;patient oriented;patient oriented research;Patients;Phase;Physicians;Postdoctoral Fellow;pragmatic trial;Preparation;prevent;Prevention Research;programs;Research;Research Project Grants;Research Training;Schools;Scientist;Tanzania;Training;Training Programs;Tropical Medicine;United States National Institutes of Health;Vaccine Research;Women's Health

PROJECT_TITLE: Mwanza-Tanzania Research Training Program in HIV Clinical Investigation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative There is a need for a highly sensitive and specific assay that can readily detect active infection by TB, particularly for yourg children in HIV-1 endemic area, who are difficult to diagnose by standard methods. Our previous work has advanced our understanding of the antigenic properties of lipoarabinomannan (LAM), a useful TB biomarker that is secreted in low concentrations into the urine of the great majority of actively infected TB patients. The current proposal will seek to further improve the sensitivity of these reagents, with the goal of developing a highly sensitive and accurate point-of-care for TB infection that is effective in young children, both with and without HIV-1 co-infection.

PI_NAMEs: PINTER, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Affinity;Aliquot;Antibodies;Antigenic Diversity;Antigens;Area;Avidity;B-Lymphocytes;Binding;Biological Assay;Biological Markers;Carbohydrates;CD4 Positive T Lymphocytes;Characteristics;Child;Childhood;co-infection;cohort;Collaborations;Collection;Detection;detection assay;detection platform;Devices;Diagnosis;diagnosis standard;Diagnostic;efficacy testing;Engineering;Epitopes;Freezing;Future;Generations;Glycolipids;Goals;HIV;HIV Infections;HIV Seronegativity;HIV-1;HIV/TB;Human;human monoclonal antibodies;Immune;Immunologics;immunoreactivity;improved;Industrialization;Infection;Kenya;Lateral;lateral flow assay;Lead;Libraries;Link;lipoarabinomannan;man;Mannosides;manufacture;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;mortality;mycobacterial;Mycobacterium tuberculosis;Nature;novel;patient screening;Patient Selection;Patients;Pediatric cohort;point of care;Polysaccharides;Population;Production;Property;Randomized;Reagent;Sampling;screening;Serum;Source;South African;Specificity;Standardization;Structure;sugar;Surface;Testing;Tuberculosis;Tuberculosis diagnosis;urinary;Urine;Variant;Vertebral column;Work;Xylose;Yeasts

PROJECT_TITLE: Enhanced POC assay for TB in HIV-infected children based on the ultrasensitive detection of the urinary form of the lipoarabinomannan antigen

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The unwanted expression of fear in safe environments is often experienced by individuals suffering from anxiety-related disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). The proposed project will provide first insight into the deep brain neurophysiological signatures of fear regulation in humans with and without anxiety disorders. Findings will characterize oscillatory and single unit activity that mediate physiological response during fear-states and help lay the foundation for future treatments for illnesses marked by debilitating unwanted fear expression.

PI_NAMEs: GILL II, JAY LATHEN  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Academic Training;Address;Adult;Affect;Amygdaloid structure;Animals;Anterior;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;anxiety-related disorders;Basic Science;Behavior;Behavioral;behavioral phenotyping;Biometry;Brain;brain research;Clinical;clinical diagnosis;Clinical Sciences;Clinical Treatment;clinically relevant;Collaborations;Communication;conditioned fear;Coupling;design;Development;Distress;effective therapy;Electrodes;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;Event;Exhibits;experience;experimental study;Extinction;Foundations;Freezing;Fright;Future;Galvanic Skin Response;Generalized Anxiety Disorder;Goals;Healthcare Systems;Heart Rate;heart rate variability;Hippocampus;Human;Implant;Implanted Electrodes;improved;Individual;Innovative Therapy;insight;Knowledge;Learning;learning extinction;Los Angeles;Mediating;Mental disorders;Mentorship;neural;neural circuit;neural network;Neuroanatomy;neuromechanism;Neurons;neurophysiology;Neurosciences;Neurosurgeon;novel;Outcome;Participant;Pattern;Phase;Physiological;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;programs;Pupil;Reaction;Regulation;Research;research clinical testing;response;Rodent;Role;Safety;Scientist;signal processing;skills;Statistical Data Interpretation;Stimulus;System;Technology;therapeutically effective;treatment strategy;United States Department of Veterans Affairs;virtual reality;virtual reality environment;Work;Writing

PROJECT_TITLE: Intracranial Neural Mechanisms of Fear Response in Humans with and without Anxiety-Related Disorders


NIH_SPENDING_CATS: Kidney Disease;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  While acute kidney injury (AKI) is common, costly, and associated with adverse outcomes, little is known about risk factors that can be identified when people are healthy where preventive strategies can potentially minimize AKI risk. We will evaluate biomarkers characterizing the functions of kidney tubules and hypothesize that kidney tubule dysfunction predicts AKI events in patients suffering from sepsis, heart failure, or undergoing coronary bypass surgery. This award will thereby provide new insights to potential mechanisms driving AKI events, and provide tools that will allow clinicians to differentiate which patients are at particularly high risk for future AKI events.

PI_NAMEs: GUTIERREZ, ORLANDO M;IX, JOACHIM H (contact);WANG, HENRY E.

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acids;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;adverse outcome;Automobile Driving;Award;Azotemia;base;Biological Markers;biomarker identification;biomarker panel;biomarker signature;Blood;cell injury;Cell Physiology;Cells;Chronic Kidney Failure;Clinical;clinical implementation;clinical predictors;cohort;Coronary Artery Bypass;cost;Creatinine;Data;Development;Disease Progression;Distal;Etiology;Event;experience;Factor Analysis;Fibrosis;follow-up;Functional disorder;Future;Generations;Health;Heart failure;Heterogeneity;high risk;Hospitalization;Hospitals;Hydration status;Impairment;Incidence;Individual;Injury;Innovative Therapy;Inpatients;insight;Kidney;kidney biopsy;Knowledge;LCN2 gene;Link;Methods;Monitor;Morbidity - disease rate;mortality;novel;Operative Surgical Procedures;Outpatients;Participant;Pathologic;Patients;Persons;Pharmaceutical Preparations;predictive marker;prevent;Prevention strategy;programs;Proteins;Proteinuria;Protocols documentation;Reasons for Geographic And Racial Differences in Stroke;recruit;Regulation;Renal function;Renal tubule structure;Research;Resources;Risk;Risk Factors;Sample Size;Sampling;Sepsis;Severities;Specimen;Stress;stressor;Survivors;Testing;tool;Tubular formation;Urine;Visit;Work

PROJECT_TITLE: Kidney Tubule Dysfunction and Future Risk of Acute Kidney Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-Z(02)]


NIH_SPENDING_CATS: Cachexia;Kidney Disease;Nutrition

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Patients with advanced chronic kidney disease (CKD) suffer from widespread tissue injuries, including skeletal muscle wasting, and they develop markedly increased blood levels of phosphate. We have found that phosphate can damage skeletal muscle cells in a dish, and that healthy mice receiving a high phosphate diet develop high blood phosphate and a mild form of skeletal muscle injury in the absence of CKD. In this research proposal, we will determine if high blood phosphate is a cause of skeletal muscle injury, by studying how exactly phosphate acts on skeletal muscle cells, whether high phosphate diet - when given over a long period of time - can cause severe skeletal muscle injury, and whether CKD mice receiving a low phosphate diet are protected from skeletal muscle wasting.

PI_NAMEs: HEITMAN, KYLIE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adenine;Affect;Age;Area;Atrophic;Biological Markers;Blood;bone;Cardiovascular Diseases;Cell Culture Techniques;cell type;Cells;Cessation of life;Chronic Kidney Failure;Clinical;clinical practice;Collagen;comorbidity;Data;Development;Diet;Epidemic;experimental study;Fatty acid glycerol esters;FGFR4 gene;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Fibrosis;Food;Genes;Genetic;Hand Strength;Health;Heart Hypertrophy;Heart Injuries;Hindlimb;Histologic;Histology;Hormones;Housekeeping;improved;In Vitro;in vivo;Individual;Inflammation;inhibitor;Injury;Injury to Kidney;inorganic phosphate;Inorganic Phosphate Transporter;Intake;Kidney;knock-down;Knockout Mice;Leg;Link;Lipids;loss of function;Magnetic Resonance Imaging;MAPK3 gene;Mediating;Metabolism;Minerals;Mitogen-Activated Protein Kinases;Molecular;Molecular Analysis;Monitor;mortality;mortality risk;mouse model;Mus;Muscle;Muscle Fibers;muscle form;Muscular Atrophy;Myoblasts;novel;Outcome;Pathologic;Pathology;Patients;Phenotype;phospholipase C gamma;Physiological;premature;prevent;Process;programs;protective effect;Protein Isoforms;PTH gene;receptor;reduced muscle strength;Renal function;Reporting;Research Proposals;Rodent;Salts;Serum;Severity of illness;Signal Induction;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle differentiation;Skeletal muscle injury;skeletal muscle wasting;Smooth Muscle Myocytes;systemic inflammatory response;Time;tissue injury;Tissues;Tubular formation;Up-Regulation;uptake;Vascular calcification;Vascular Smooth Muscle;Vitamin D;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in the Absence and Presence of Chronic Kidney Disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: With 24.3 million people affected worldwide in 2005 and an estimated rise to nearly 45 million in 2020, Alzheimer's disease is a leading unmet medical need. The goal herein is to optimize oral bioavailability and kinase selectivity of an efficacious proof-of-concept DYRK1A inhibitor and evaluate an optimal candidate in 3xTg-AD and JNPL3 mouse models of AD. Such a molecule may have potential as a disease-modifying therapy through unique dual targeting of tau and amyloid pathologies.

PI_NAMEs: DUNCKLEY, TRAVIS L;HULME, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Address;Adverse effects;Affect;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;analog;Animals;attenuation;Back;Behavioral;Binding;Biological Assay;Biological Availability;Brain;Cell Aging;Chronic;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive enhancement;Coupled;Crystallization;Data;design;Development;Disease;Dose;Exhibits;Goals;Hand;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Intervention;Life;Measures;Medical;Modeling;Motor;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;novel;novel therapeutic intervention;Oral;Pathology;Pathway interactions;Peptides;Persons;Pharmaceutical Chemistry;Phosphorylation;Phosphotransferases;pre-clinical;Process;protein degradation;Proteins;Role;screening;Selection Criteria;Senile Plaques;small molecule;Specificity;Structure;success;tau aggregation;tau Proteins;Testing;Therapeutic;Time;Toxicology;Triage;Tyrosine Phosphorylation;Writing

PROJECT_TITLE: DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Microbiome;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: NEUROSCIENCES

PHR: NARRATIVE  Disturbances in gut microbial communities and leaky gut may contribute to inflammation and blood-brain barrier (BBB) dysfunction in HIV. Cannabis may help to normalize dysbiosis and leaky gut, thus reducing inflammation and BBB dysfunction. This project will evaluate differences in dysbiosis, leaky gut, neuroinflammation and BBB dysfunction in PWH and evaluate the therapeutic potential of cannabidiol and tetrahydrocannabinol in a clinical trial of controlled cannabis formulations.

PI_NAMEs: ELLIS, RONALD J. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: antiretroviral therapy;Apoptosis;Attention;authority;B-Lymphocytes;Bacteria;Bacteroides;Bifidobacterium;Biological Markers;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier function;blood-brain barrier permeabilization;Butyrates;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;CD4 Positive T Lymphocytes;Cellular Immunology;Cerebrospinal Fluid;Chronic;Clinical;Clinical Investigator;Clinical Trials;CNR2 gene;Conduct Clinical Trials;Controlled Clinical Trials;Data;Disease;Dronabinol;dysbiosis;efficacy evaluation;Endocannabinoids;endogenous cannabinoid system;Epidiolex;Epithelial Cell Proliferation;Epithelium;exogenous cannabinoid;experience;Exposure to;Formulation;Functional disorder;Gastrointestinal tract structure;Goals;gut dysbiosis;gut inflammation;gut microbiome;gut microbiota;HIV;Human;Immunologist;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;Intervention Studies;Intestinal permeability;Large Intestine;Leaky Gut;Ligands;Link;Literature;Lymphocyte;Lymphoid Tissue;marijuana use;Measures;Mediating;Mediation;Mediator;metagenomic sequencing;microbial;microbiome;microbiota;microorganism antigen;Modeling;monocyte;Multiple Sclerosis;neuroinflammation;Neurologist;Neuropathogenesis;Oral;Oral Administration;Outcome;Outcome Measure;Pathway interactions;Pattern;Permeability;Persons;Pharmaceutical Preparations;phytocannabinoid;preclinical study;Predisposition;Prevotella;Production;Publishing;Randomized;remediation;repaired;Research;Research Personnel;response;Syndrome;System;T-Cell Depletion;T-Lymphocyte;Tetrahydrocannabinol;Therapeutic;Tight Junctions;Tissues;Viral;Work

PROJECT_TITLE: Effects of Cannabidiol and Tetrahydrocannabinol on the Microbiome, Endocannabinoids and Neuroinflammation in HIV


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: NRG ONCOLOGY FOUNDATION, INC.

ORG_STATE: PA

PHR: The collection, management and distribution of high quality and well annotated biospecimens associated with NRG clinical trials data will lead to translational studies for validating biomarkers of tumor prognosis and prediction of response to therapy, ultimately leading to improved treatment of cancer patients. These activities will support improved quality of biospecimens, and expanded access for translational scientists, thus leading to better quality research and identifying appropriate patients for personalized approaches to improved cancer care.

PI_NAMEs: FREEMAN, TANNER J.;RAMIREZ MILAN, NILSA DEL CARMEN;SIMKO, JEFF P (contact)

PROGRAM_OFFICER_NAME: MAKHLOUF, HALA

PROJECT_TERMS: Address;Adopted;Adult;advanced disease;arm;biobank;Bioinformatics;Biological Markers;Biological Specimen Banks;biomarker validation;Brain;Breast;cancer care;cancer clinical trial;Cancer Patient;cancer therapy;Catalogs;Chest;Clinical;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Collection;Communication;Communities;Community Clinical Oncology Program;Data;digital imaging;Disease;Enrollment;Epidemiology;Equipment and supply inventories;Equity;experience;Feedback;Foundations;Freezing;Funding;Future;Gender;Genomics;Goals;Gynecologic Oncology Group;Head and neck structure;Health protection;improved;Influentials;Informatics;Information Systems;Infrastructure;innovation;Institution;interest;interoperability;Jordan;Knowledge;Laboratories;Link;Liquid substance;Lung;Malignant Neoplasms;Marketing;member;Methods;National Cancer Institute;National Clinical Trials Network;National Surgical Adjuvant Breast and Bowel Project;Non-Hematologic Malignancy;Normal tissue morphology;Oncology;oncology trial;operation;Outcome;participant enrollment;patient population;Patients;Performance;performance site;personalized approach;Phase;Positioning Attribute;Prediction of Response to Therapy;preservation;Privatization;Process;Prognosis;Protocols documentation;Publications;Qualifying;quality assurance;Radiation Therapy Oncology Group;Reporting;repository;Research;Research Personnel;sample collection;Sampling;Science;Secure;Services;Site;Specimen;Standardization;System;targeted therapy trials;Tissues;Translational Research;translational scientist;translational study;treatment trial;tumor;Tumor Markers;Tumor Tissue;United States National Institutes of Health;Work

PROJECT_TITLE: NRG Oncology Biospecimen Bank


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECTIVE NARRATIVE The objective of this grant is to study the detailed molecular and cellular mechanisms by which chronic exposure to stimulant and opioid drugs of abuse alters the structure and function of neurons within the brain’s reward circuitry. These studies will provide new information concerning how drugs of abuse cause a state of addiction as well as identify novel leads toward the development of improved diagnostic tests and treatments.

PI_NAMEs: NESTLER, ERIC J. (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Actins;addiction;Address;Affect;Amygdaloid structure;analytical tool;Applications Grants;Attention;Automobile Driving;Behavior;Behavioral;behavioral plasticity;Binding Proteins;Brain;Brain region;Categories;cell type;Cells;Chronic;Classification;Cocaine;cocaine exposure;cocaine relapse;cocaine self-administration;Cocaine withdrawal;Corpus striatum structure;Cytoskeleton;Dendritic Spines;density;Development;Diagnostic tests;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Dorsal;drug action;Drug Addiction;drug discovery;Drug Exposure;drug of abuse;Drug Targeting;Excitatory Synapse;experimental study;Family member;Female;Future;Genes;Glutamates;Grant;Growth;Heroin;Heterogeneity;hippocampal pyramidal neuron;Hippocampus;improved;inhibitor;insight;Knowledge;Life Cycle Stages;Link;male;Medial;Mediating;Methods;Microtubule Proteins;Microtubule-Associated Proteins;Microtubules;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mus;Neurons;novel;Nucleus Accumbens;Opioid;opioid abuse;opioid exposure;Pathway interactions;Pharmaceutical Preparations;Play;Prefrontal Cortex;Property;Prosencephalon;Proteins;Receptor Cell;Regulation;Relapse;Research;response;reward circuitry;Rewards;Role;segregation;Self Administration;Shapes;Signal Transduction;single cell analysis;single cell technology;single-cell RNA sequencing;src-Family Kinases;Stimulant;stimulant exposure;Stimulus;Structure;Thinness;Time;Transgenic Mice;Uncertainty;Vertebral column;virtual;Work

PROJECT_TITLE: Neurotrophic Mechanisms in Cocaine and Opiate Action

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Non-alcoholic fatty liver disease (NAFLD) affects >30% of the US population and is projected to become the leading cause of liver-related death in the US within the next 20 years; however, predicting which patients with NAFLD ultimately develop advanced liver disease is challenging and this knowledge gap impairs allocation of resources to the highest-risk patients. Genetics and electronic medical record-derived data may provide additional information that assists with risk stratification, and the research proposed here will incorporate genetics with the electronic medical record to generate predictive models for incident cirrhosis among patients with NAFLD. Ultimately, this project will allow medical providers to better identify which patients with NAFLD are at highest risk of progression and accordingly prioritize them for intensive therapy.

PI_NAMEs: CHEN, VINCENT LINGZHI (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Affect;Age;Alleles;American;Applied Genetics;Award;base;biobank;Biopsy;Calibration;career;Cessation of life;Cirrhosis;Clinical;clinical practice;cohort;comorbidity;Complex;Computerized Medical Record;cost;Data;Data Set;demographics;disease diagnosis;disease model;Disease Progression;elastography;Event;Fatty Liver;Fibrosis;follow-up;gene environment interaction;Genetic;genetic predictors;genetic risk factor;genetic variant;genome wide association study;Goals;Grant;Heritability;Heterogeneity;high risk;Impairment;improved;indexing;interest;Intervention;Knowledge;Laboratories;lifestyle intervention;Link;Literature;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Medical;Medical Genetics;Medicine;Metabolic;Michigan;Modeling;mortality risk;multidimensional data;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;novel;outcome prediction;Participant;Patient Care;Patients;Persons;pharmacologic;Phenotype;polygenic risk score;Population;Precision Health;predictive modeling;Process;progression risk;prospective;Provider;Quality Control;Research;Research Personnel;Resource Allocation;Risk;Risk Factors;risk prediction;risk stratification;Source;Structure;Subgroup;substance use;Time;Training;United States;Variant;weight loss program;Writing

PROJECT_TITLE: Predictive models for incident cirrhosis in non-alcoholic fatty liver disease using genetic and electronic medical record-based risk factors

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BASKIN-SOMMERS, ARIELLE RYAN (contact);CASEY, BETTY J;GEE, DYLAN GRACE

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 7/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT YALE


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Infectious Diseases;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Wound Healing and Care

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative: Biofilm, a protective extracellular-polymeric substance that surrounds bacterial colonies, is associated with more than 80% of microbial infections. This proposed study aims to improve biofilm removal from an infected wound using self-locomotive antimicrobial micro-robots (SLAM) and, in turn, to promote skin regeneration in the wound. If successful, this proposed study would greatly contribute to saving wound patients from death and disability resulting from microbial infection.

PI_NAMEs: KONG, HYUNJOON  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 3-Dimensional;Aging;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bioimaging;Blood;CD34 gene;Cell secretion;Cell Wall;Cells;Cessation of life;Chronic;Clinical;Collaborations;Collagen;Complex;cost;Cytoprotection;Debridement;Deposition;Dermatologist;Diatoms;disability;Disease;Disinfectants;Disinfection;Edema;efficacy evaluation;Enzymes;epithelial wound;Excision;Exhibits;extracellular;Female;FGF2 gene;Fibroblast Growth Factor;Fracture;Gelatinase B;Goals;Growth;Growth Factor;Human body;Hydrogen Peroxide;imaging system;Immune system;Impaired wound healing;improved;Infection;Inflammation;inhibitor;innovation;Invaded;invention;Irrigation;keratinocyte growth factor;Liquid substance;Locomotion;male;Malignant - descriptor;Matrix Metalloproteinases;mechanical energy;Metabolic;Metalloproteases;methicillin resistant Staphylococcus aureus;Methods;microbial;Microbial Biofilms;Microbubbles;microrobot;MMP9 gene;Modeling;Monitor;Multi-modal optical imaging;Mus;nanosheet;neovascularization;Oxygen;Patients;Polymers;Porosity;prevent;Procedures;Pseudomonas aeruginosa;PTPRC gene;re-epithelialization;Recombinants;Recurrence;Regenerative Medicine;Residual state;Scheme;Self Efficacy;Services;Site;Skin;skin regeneration;stem;Stem Cell Mobilization;stem cells;Structure;success;Surveys;Thick;Time;Tissues;Toxic effect;Translating;traumatic event;treatment duration;United States;United States National Institutes of Health;Vancomycin;Vascularization;Water;wound;wound biofilm;wound healing;Wound Infection;wound treatment

PROJECT_TITLE: Self-Locomotive Antimicrobial Micro-Robot (SLAM) Enhancing Biofilm-Infected Wound Healing

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Intrahepatic macrophages (Macs), liver sinusoidal endothelial cells (LSECs), and stellate cells (HSCs) can greatly influence the composition of the hepatic microenvironment and development of fibrosis. Therapies targeting these initiators of fibrosis are being investigated in phase II-III clinical trials; however, the underlying hepatic microenvironment and patient variability in these cells and expression of these targets is not being considered prior to treatment. In this retrospective longitudinal study, we will determine which platform (Spectral imaging-Aim1 vs. NanoString-Aim 2) is the most performant for determining potential targets of fibrosis progression and most cost efficient for clinical implementation in the future.

PI_NAMEs: STEVENSON, HEATHER L (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acids;Advanced Development;Alcoholic Liver Diseases;Alcohols;Anti-Inflammatory Agents;Antigens;Archives;Autoimmune Hepatitis;biobank;Bioinformatics;Biological Markers;Biological Models;Biopsy;Blood;CCL2 gene;CCR5 gene;Cells;Chronic Hepatitis;chronic liver disease;Cirrhosis;Clinical;clinical care;clinical implementation;Clinical Research;Clinical Treatment;Clinical Trials;Complement;cost;cost efficient;Data;Data Analyses;design;Development;Diagnosis;Discontinuous Capillary;Disease;Economic Burden;Endothelial Cells;Etiology;Exhibits;Eye;Fibrosis;follow-up;Formalin;Future;Galectin 3;Gatekeeping;Gene Expression Profile;Genes;Health;Hepatic;Hepatitis C virus;Human;Image;Immunotherapy;improved;In Situ;In Vitro;Inflammatory;Injury;innovation;intrahepatic;Kupffer Cells;Life Style Modification;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver injury;Location;Longitudinal Studies;Macrophage;Malignant Neoplasms;Mediator;microscopic imaging;Molecular;mouse model;nano-string;non-alcoholic fatty liver disease;non-compliance;nonalcoholic steatohepatitis;Outcome;Paraffin Embedding;Pathogenicity;patient variability;Patients;Perisinusoidal Space;personalized medicine;Phase;Phenotype;Population;Predisposition;Primary carcinoma of the liver cells;Prior Therapy;Process;prognostic;Progressive Disease;prospective;Pruritus;Recommendation;recruit;response;risk prediction;side effect;Slide;spectrograph;standard of care;stellate cell;targeted treatment;Techniques;Technology;Testing;therapeutic candidate;Therapeutic Intervention;therapeutic target;Time;Tissue Embedding;Tissue Stains;Tissues;Transforming Growth Factor beta;Tumor Necrosis Factor-Beta;Variant

PROJECT_TITLE: ANALYSIS OF INTRAHEPATIC MACROPHAGE PROFILES FOR PREDICTING RISK OF FIBROSIS DEVELOPMENT IN PATIENTS WITH DIFFERENT TYPES OF CHRONIC LIVER DISEASE

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Multiple factors contribute to poor outcomes among minority patients with asthma, including poverty and other social determinants of health (SDoH), environmental exposures, and suboptimal self-management skills. Mobile interventions that facilitate shared decision-making and address modifiable factors in asthma management, such as medication adherence and optimal screening and referrals for SDoH concerns, may play a key role in improving disease outcomes. This proposed project will: 1) adapt, test, and iteratively refine the ASTHMAXcel Voice mobile platform to collect vocal biomarkers and address SDoH; 2) conduct a randomized clinical trial at outpatient sites to compare the adapted and refined ASTHMAXcel Voice intervention to usual care; and 3) evaluate the process of ASTHMAXcel Voice implementation within the outpatient setting.

PI_NAMEs: FELDMAN, JONATHAN M. (contact);JARIWALA, SUNIT

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: A novel patient-facing mobile platform to collect and implement patient-reported outcomes and voice biomarkers in underserved adult patients with asthma

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


FUNDING_MECHANISM: OTHERS

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: The goal of the proposed research is to uncover biomarkers of post-traumatic stress disorder (PTSD) by investigating epigenomic and transcriptomic changes associated with this disorder. Results of this work may help inform novel preventive strategies and personalized care for PTSD in U.S. veterans. !

PI_NAMEs: MONTALVO-ORTIZ, JANITZA LIZ (contact)

PROJECT_TERMS: Age;Arousal;Bioinformatics;bioinformatics tool;Biological Markers;biomarker identification;Candidate Disease Gene;Chronic;Cognition;Cohort Studies;collaborative environment;combat;Data;Data Analyses;Data Set;differential expression;Disabling;Disabling condition;Disease;DNA;DNA Methylation;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenomics;Etiology;Event;experience;Exposure to;functional genomics;Funding;Gene Expression;gene network;Gene set enrichment analysis;Genes;Genetic;Genome Scan;genome wide association study;genome-wide;genome-wide analysis;Genomics;Goals;Grant;Health;Healthcare;Healthcare Systems;improved;individual variation;innovation;insight;Institution;Interdisciplinary Study;International;Knowledge;Lead;Learning;Linear Regressions;longitudinal analysis;Longitudinal Studies;Mediation;Mendelian randomization;Mental disorders;Mentorship;Methods;Methylation;Military Personnel;Modeling;molecular marker;Monitor;Moods;multidisciplinary;multilevel analysis;Multiomic Data;multiple omics;Neurosciences;novel;Pathway Analysis;Peripheral;personalized care;Phenotype;Positioning Attribute;Post-Traumatic Stress Disorders;Prevalence;Prevention;Prevention strategy;programs;psychiatric genomics;Psychiatry;Publishing;recruit;reference genome;Research;Research Personnel;Residual state;resilience;Risk;RNA;Role;saliva sample;Sample Size;Sampling;Site;skills;Statistical Methods;supportive environment;symposium;Symptoms;Tissue-Specific Gene Expression;Tissues;tool;Training;Transcript;transcriptome sequencing;transcriptomics;Trauma;Veterans;Work

PROJECT_TITLE: Identifying Biomarkers of Post-traumatic Stress Disorder in U.S. Veterans using an Integrative Multi-Omics Approach


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: For more than a century, radiation has been used as an effective therapeutic modality for many different cancers and other diseases, and is clinically indicated for more than half of all cancer patients. However, it has long been known that ionizing radiation can also promote cancer in otherwise normal tissue. While it is rare for an individual to develop a radiation- induced cancer, actual estimates of this rate vary widely according to different studies. Moreover, we have a poor understanding of individualized risk and, in particular, the role that personal genetics may play in determining relative risk of developing a radiation-induced cancer. My research aims to 1) identify a high-confidence cohort of Veterans receiving radiation therapy, 2) characterize second and secondary malignancy rates within the VA, and 3) quantify genetic risk factors of radiation-induced secondary malignancies.

PI_NAMEs: THOMPSON, REID  (contact)

PROJECT_TERMS: anti-cancer;Area;Biological;Cancer Patient;cancer predisposition;cancer risk;cancer therapy;carcinogenesis;Cells;Clinical;clinical decision-making;cohort;Counseling;Data;data warehouse;Defect;Development;Diagnostic Imaging;Disease;DNA Damage;DNA Repair;Dose;Exposure to;Fractionation;General Population;Genetic;Genetic Determinism;Genetic Predisposition to Disease;genetic risk factor;genetic variant;Germ Lines;Goals;high risk;improved;Incidence;Individual;insight;Ionizing radiation;Left;Life;Location;Malignant Neoplasms;Measures;Modality;Nature;neglect;Normal tissue morphology;palliation;Patients;Persons;Play;Population;programs;prospective;Radiation;Radiation Dose Unit;Radiation exposure;radiation risk;Radiation therapy;Radiation-Induced Cancer;rare variant;Relative Risks;repaired;Research;Resources;Risk;Risk Assessment;risk prediction;Role;screening;Second Primary Cancers;Second Primary Neoplasms;Secondary to;Stratification;Susceptibility Gene;Testing;Therapeutic;therapeutically effective;therapy outcome;Time;tool;treatment site;Variant;Veterans;virtual

PROJECT_TITLE: Quantifying and improving radiotherapy outcomes among Veterans


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The molecular mechanisms that drive myelodysplastic syndrome (MDS) progression and responses to hypomethylating agent (HMA) therapy are poorly understood. Our single-cell RNA-sequencing studies of MDS patients with progressive cytopenias have demonstrated that MDS hematopoietic stem cells (HSCs) exhibit unique gene expression profiles and splicing patterns from normal controls, with responders and non-responders to HMA therapy exhibiting differences in gene expression and splicing. We will leverage novel single cell sequencing technologies to simultaneously evaluate the transcriptional and genetic states of MDS HSCs and committed progenitors to elucidate the molecular basis of disease progression and therapeutic responses.

PI_NAMEs: MASON, CHRISTOPHER EDWARD;PARK, CHRISTOPHER Y (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: acquired bone marrow failure;Acute Myelocytic Leukemia;Address;Alleles;Antibodies;Biological;bone marrow failure syndrome;Candidate Disease Gene;CD34 gene;Cells;Clinical;Clinical Research;clinically relevant;cohort;Collaborations;Complementary DNA;computational pipelines;cytopenia;Data;Disease Progression;Dysmyelopoietic Syndromes;Exhibits;experience;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;genetic approach;Genetic Transcription;Hematology;Hematopoietic stem cells;Heterogeneity;improved;in vivo;Individual;ineffective therapies;Introns;Length;leukemia;leukemic transformation;Mediator;Minority;Molecular;mouse model;Mutation;new therapeutic target;novel;novel marker;Outcome;Pathway interactions;patient response;Patients;Pattern;Population;Positioning Attribute;predictive marker;progenitor;prognostication;programs;Research;Research Personnel;Resistance;responders and non-responders;response;RNA;RNA Editing;RNA Splicing;Role;Sampling;single cell sequencing;single-cell RNA sequencing;Site;Somatic Mutation;Spliced Genes;stem cells;targeted agent;Technology;Therapeutic;Transcript;transcriptome;treatment response

PROJECT_TITLE: Clinical and Molecular Heterogeneity in the Myelodysplastic Syndromes

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE  We will study biopsies obtained from HSV-2 infected individuals who took part in an HSV-2 vaccine study to find where the T cells that recognize HSV-2 are, what part of HSV-2 they recognize, and what types of work those cells are doing in the tissue. We would like to know what types of T cells are fighting HSV-2 and eventually figure out which cells are the most successful at doing this, to try to develop an HSV-2 vaccine.

PI_NAMEs: FORD, EMILY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;Animal Model;Antigenic Specificity;Antigens;Area;arm;Biopsy;Blood;Blood Cells;career;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Chronic;Clinical;Containment;cytokine;design;Development;Disease;Dose;educational atmosphere;Effectiveness;Epidemic;Epitope Mapping;Epitopes;experience;fighting;first responder;foot;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic Transcription;Genitalia;global health;Goals;Health Benefit;Herpes Simplex Virus Vaccines;Histologic;HIV;HIV-1;Human;Human Herpesvirus 2;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunotherapeutic agent;improved;In Situ Hybridization;Individual;Infection;Investigation;K-Series Research Career Programs;Laboratories;Lead;Learning;lens;Location;Mentors;Molecular;Morbidity - disease rate;Natural History;Nerve Endings;optimism;Peripheral Blood Mononuclear Cell;Peripheral Nerves;Persons;Phase;Phenotype;Play;Population;Principal Investigator;Production;Productivity;programs;Public Health;public health relevance;repository;Research;Research Personnel;Risk;RNA;Role;Sampling;Series;Simplexvirus;Site;skills;Skin;skin biopsy;Specificity;T cell receptor repertoire sequencing;T cell response;T-Cell Immunologic Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;Testing;Time;Tissue Expansion;tissue resident memory T cell;Tissues;transcriptomics;transmission process;Ulcer;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine trial;Vaccinee;Vaccines;Viral;Viral Antigens;Visualization;Work

PROJECT_TITLE: HSV-2 specificity and phenotyping of tissue-based T cells in genital skin biopsies of HSV-2 reactivation

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Circadian rhythms control a wide variety of processes in all eukaryotes, including linkages to the cell cycle, human metabolism and cancer. The fundamental organization of the clock as consisting of two or more, linked autoregulatory feedback loops is shared among all model systems, but the individual molecular players often vary among the kingdoms. Here inter- and intracellular mechanisms of circadian clock control in Arabidopsis are investigated, with potential relevance to other eukaryotic oscillatory systems.

PI_NAMEs: SOMERS, DAVID E (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Affect;Arabidopsis;Biochemical;Biological;Biological Models;Cell Cycle;Cell Nucleus;Cells;cellular imaging;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Complex;Cytosol;Developmental Process;Environment;Eukaryota;Feedback;Gatekeeping;Genetic;Genomics;Glucose;Goals;Hour;Human;Imaging Techniques;Individual;Link;Malignant Neoplasms;Meristem;Metabolism;Molecular;Movement;mutant;Nuclear Pore;Organism;Phase;Phosphotransferases;Photoreceptors;Physiological Processes;Plant Model;Plants;Post-Transcriptional Regulation;Post-Translational Protein Processing;Process;programs;Proteins;RNA Processing;Running;Signal Transduction;Small RNA;System;Time;tool

PROJECT_TITLE: Inter- and intracellular mechanisms of circadian regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: PROJECT NARRATIVE Tuberculosis is one of the commonest causes of death from infections worldwide, but no new vaccines for TB have been introduced in nearly 100 years. Despite this gap, little is known about how the lung environment shapes the immune response to M. tuberculosis, the organism that causes tuberculosis. By the end of this proposal, we will understand how respiratory mucins, the first proteins that M. tuberculosis encounters in the lung, influences susceptibility and severity to tuberculosis, and may identify novel treatment and vaccine strategies

PI_NAMEs: SHAH, JAVEED ALI (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: adaptive immune response;Adverse effects;Alveolar;Alveolar Macrophages;Animal Model;anti-microbial peptide;antimicrobial;Bacterial Infections;Bacterial Pneumonia;biobank;Biology;Cause of Death;Characteristics;Clinical;cohort;Complement;Complex;cost;cytokine;Data;Development;Disease;disease model;Disease susceptibility;Dissection;Environment;extracellular;Functional disorder;Future;Gene Expression;Gene Modified;Genetic;Genetic Polymorphism;Genetic study;genetic variant;Genetic Variation;glycosylation;Goals;Grant;Growth;Homeostasis;Host Defense;Human;Human Genetics;IL17 gene;Immune;immune activation;Immune response;Impairment;improved;in vivo;Individual;Infection;Inflammation;Inflammatory Response;Innate Immune Response;innovation;Integration Host Factors;interest;Interleukin-13;interleukin-23;Investigation;Knock-out;Knowledge;Lung;Lung Diseases;lung pathogen;macromolecule;Macrophage;Maps;Measures;Meningeal Tuberculosis;migration;mortality;mouse model;mRNA Expression;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;mucosal vaccination;Mucous Membrane;multiple myeloma M Protein;Mus;mycobacterial;Mycobacterium tuberculosis;novel;novel vaccines;Organism;Outcome;overexpression;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Persons;Phenotype;Play;Population;Predisposition;prevent;Promoter Regions;Proteins;Pulmonary Fibrosis;Pulmonary Pathology;Pulmonary Tuberculosis;Respiratory Mucin;response;Role;Sampling;Severities;Severity of illness;Shapes;Signal Transduction;Specificity;Structure of parenchyma of lung;Susceptibility Gene;Symptoms;Testing;Therapeutic;Tissues;TNF gene;translational impact;transmission process;treatment strategy;Tuberculosis;Tuberculosis Vaccines;tumor;tumor-immune system interactions;vaccine strategy;Vaccines;Variant;Vietnam;Vietnamese;Viral;Work

PROJECT_TITLE: The impact of mucociliary clearance on Mycobacterium tuberculosis pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: This application is for the position of Research Career Scientist for Dr. L. Ashley Cowart, Ph.D. Dr. Cowart is an internationally recognized expert in lipid metabolism and its contribution to health and disease. Her research focuses on obesity and related illnesses including type 2 diabetes, non-alcoholic fatty liver disease, and heart failure. Studies show that over 75% of veterans of the Iraq and Afghanistan wars are overweight or obese. Furthermore, obesity is highly linked to post traumatic stress disorder. Dr. Cowart has recently begun new work to identify novel lipid that could predict the risk of post-traumatic stress disorder in veterans who experienced traumatic brain injuries while deployed. Dr. Cowart has been VA funded since 2005 and is currently funded through December 2025. In addition to VA funding, she has served as PI on 2 NIH R01 grants, with funding through June 2025. This award will provide stability and continuity as Dr. Cowart furthers her overall research program which extends well beyond the proposed work in the current Merit award.

PI_NAMEs: COWART, LAUREN ASHLEY (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Afghanistan;alcohol use disorder;Alcoholic Liver Diseases;Anabolism;Applications Grants;Atherosclerosis;Attenuated;Autophagocytosis;Award;Back;base;Basic Science;Bibliography;Biological Markers;biomarker discovery;Blood;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;career;Cells;Ceramides;Collaborations;Communities;Complement Factor H;Development;Diabetes Mellitus;diabetic cardiomyopathy;Diet;dihydroceramide desaturase;Disease;Doctor of Philosophy;Environment;Enzymes;Estrogens;experience;Extramural Activities;Faculty;Fatty Acids;fatty liver disease;Female;forging;Foundations;Funding;Grant;Health;Healthcare Systems;Heart Diseases;Heart failure;Heart Hypertrophy;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;high risk;Inflammation;inhibitor;interest;International;Investigation;Investments;Iraq;Joints;K-Series Research Career Programs;Knock-out;Knockout Mice;Laboratories;Laws;Link;lipid metabolism;Lipids;Liver;Liver diseases;Manuscripts;Mediating;Mediator;Medical;member;Mental Depression;Mental disorders;Mentors;Metabolic Diseases;Metabolic syndrome;Metabolism;mid-career faculty;Mitochondria;Molecular;mouse model;Mus;Myocardial dysfunction;Myocardial Ischemia;Myocardium;Myristates;non-alcoholic;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;Obesity associated disease;obesogenic;Oleic Acids;Organ;Overweight;Oxidative Stress;Palmitates;Palmitic Acids;Pathology;Pathway interactions;Phenotype;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Preparation;prevent;problem drinker;Production;professor;programs;Publications;Publishing;Regulation;Research;Research Personnel;Research Project Grants;Risk Factors;risk prediction;Role;Scientist;Seminal;Signal Transduction;Skeletal Muscle;South Carolina;Sphingolipids;sphingosine 1-phosphate;SPHK1 enzyme;synergism;TBI Patients;Thermogenesis;Tissues;Training;Traumatic Brain Injury;United States National Institutes of Health;Universities;Unsaturated Fatty Acids;Veterans;Virginia;War;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

PHR: Preclinical experimental model systems, which accurately depict human cancer, is critical in translating laboratory findings to the clinic. We discovered aberrant GRM1 expression in a large number of late-stage melanoma patients. However, current melanoma animal models do not mimic this common genetic alteration. We, therefore, propose to use our unique experimental mouse models reflecting this cancer-driving modification and focus in melanoma brain metastasis that remains a clinically challenge aspect of this disease. A better understanding of the characteristics of brain metastases is essential to develop more effective therapeutic strategies to treat or prevent brain metastases.

PI_NAMEs: CHEN, SUZIE  (contact)

PROJECT_TERMS: Academia;American Association for the Advancement of Science;amyotrophic lateral sclerosis therapy;Animal Model;anti-cancer research;Appointment;Area;Automobile Driving;Award;Basic Science;Biological Availability;Biological Models;Biology;biomarker identification;Brain;Cancer Institute of New Jersey;Cancer Patient;Cancer Therapy Evaluation Program;career;Cell surface;cell transformation;Central Nervous System;Characteristics;Chemicals;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Cytochrome P450;Development;Discipline;Disease;distinguished professor;drug discovery;Ectopic Expression;Epithelial Cells;Etiology;Experimental Models;experimental study;FDA approved;Fellowship;Glioma;glutamatergic signaling;Glutamates;Goals;Grant;GRM1 gene;Half-Life;Health;Human;human model;improved;In Vitro;in vivo;Industry Collaboration;innovation;inter-individual variation;interest;Investigation;Joints;Knowledge;Laboratories;Laboratory Finding;Learning;Legal patent;Lesion;Ligands;Longitudinal Studies;Lung;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medical center;melanocyte;Melanoma;Melanoma patient;melanomagenesis;Memory;Metabolism;metabotropic glutamate receptor type 1;Metabotropic Glutamate Receptors;Metastatic malignant neoplasm to brain;Modeling;Modification;molecular pathology;mouse model;Multi-Institutional Clinical Trial;Mus;Mutation;National Cancer Institute;Neoplasm Metastasis;Neurons;Oncogenic;Oranges;Organ;Patient Recruitments;Patients;Peer Review;Pennsylvania;Pharmacotherapy;Pharmacy Schools;Phase;Physicians;Postdoctoral Fellow;pre-clinical;prevent;Probability;Prodrugs;Prognostic Marker;programs;Property;Publications;receptor;Renal Carcinoma;Research;Research Personnel;Research Project Grants;Research Support;Rewards;Riluzole;Role;Scientist;screening;Secure;Signal Pathway;Signal Transduction;Site;Small Business Innovation Research Grant;System;Technology;Testing;therapeutically effective;tool;Toxic effect;Transgenic Mice;Translating;translational applications;translational model;Translational Research;Translations;Trustees;tumor;Universities;Work


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: The goal of the Chen lab’s VA-funded research is to curtail the grave consequences of traumatic brain injury (TBI) and ischemic stroke on our veterans’ health and wellbeing. To meet this goal, our research team seeks to understand the regulatory role of immune cells in the progression of brain injury and functional recovery after TBI or stroke. We seek to identify the mechanisms underlying the double-edged sword of microglial activation and brain infiltration of circulating immune cells. We have successfully developed numerous strategies to harness the tissue-restorative power of immune cells while also tempering inflammation-induced secondary injuries. We will comprehensively test these strategies using state-of-the art assessments of long-term neurological functions in both male and female subjects. This molecular, cellular, and systems-level evidence will be valuable for future development of new therapies to minimize veteran disabilities, promote veteran rehabilitation, and improve quality of life after TBI or stroke.

PI_NAMEs: CHEN, JUN  (contact)

PROJECT_TERMS: Acceleration;Acute;Affect;aged;Aging;aging brain;Agonist;Alteplase;animal old age;Anti-Inflammatory Agents;Area;Attention;Award;axon injury;Bexarotene;Biological;Blood Vessels;blood-brain barrier disruption;Brain;brain cell;Brain Injuries;Brain Ischemia;brain repair;brain tissue;career;Caring;Cells;Cerebrovascular Circulation;Chronic;clinical investigation;Clinical Treatment;clinically relevant;Cognitive;Cognitive deficits;cognitive function;Collaborations;cytokine;Data;Development;disability;disabled;Economic Burden;effective therapy;Elderly;Emergency Care;FDA approved;Funding;Future;Generations;Genetic;glial activation;Goals;Grant;Grant Review;Growth;Health;Health system;Healthcare;Hospitalization;HSPB1 gene;Immune;Immune response;Immune system;Immunity;Impaired cognition;Impairment;improved;indexing;Infiltration;Inflammation;Injury;injury and repair;injury recovery;Institution;Interleukin-4;Ischemic Brain Injury;Ischemic Stroke;Journals;Level of Evidence;Long term disability;long term recovery;Macrophage;male;Manuscripts;mature animal;Medical center;Metabolism;Microglia;military veteran;Molecular;Moods;Mus;National Institute of Neurological Disorders and Stroke;Natural regeneration;Nervous System Physiology;Neurologic;neurological recovery;novel;novel therapeutics;Omega-3 Fatty Acids;Outcome;Outcomes Research;Paper;Peer Review;Personal Satisfaction;pharmacologic;Phenotype;Phylogenetic Analysis;Population;post stroke;Post-Traumatic Stress Disorders;pre-clinical;Process;programs;Protein Kinase;psychiatric symptom;Publications;Quality of life;Recovery;Recovery of Function;Regulatory T-Lymphocyte;Rehabilitation therapy;Rejuvenation;repair function;repaired;Reporting;Research;Research Personnel;response;restoration;Role;RXR;Safety;salt-inducible kinase;Scientist;socioeconomics;Stroke;stroke model;stroke outcome;stroke victims;Survivors;Synapses;System;TBI treatment;Testing;Therapeutic;Thinking;tissue repair;Tissues;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States National Institutes of Health;Universities;Veterans;white matter;white matter injury;women subjects;Work;young adult


ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

ORG_STATE: FL

PHR: Dr. Zaika's research focuses on the molecular analyses of esophageal and gastric adenocarcinomas. The incidence of gastroesophageal reflux disease, the main risk factor for esophageal adenocarcinoma, is significantly higher in our veterans' population compared to general population. Furthermore, recent studies of U.S soldiers deployed abroad have shown that the incidence of H. pylori infection is approximately three-fold higher than that of U.S. military recruits serving at home, which represents a major increase in gastric cancer risk. Taken together, the molecular and translational research activities of Dr. Zaika's laboratory are highly relevant to our Veterans' health.

PI_NAMEs: ZAIKA, ALEXANDER I. (contact)

PROJECT_TERMS: Achievement;Acids;adduct;Affect;Animal Model;Area;Asia;Award;Bacteria;Barrett Esophagus;Basic Science;Belief;Biochemical;Biochemistry;Bioinformatics;biological adaptation to stress;Cancer Biology;Cancer Center;Cancer Control;Cancer Patient;cancer prevention;cancer risk;Cancer Science;cancer surgery;cancer therapy;Carcinogenesis Mechanism;carcinogenicity;career;CDKN2A gene;Cells;Cellular biology;Chemistry;ChIP-seq;Chronic;Clinical;clinical investigation;Clinical Research;Clinical Sciences;Collaborations;Complex;Development;Diagnosis;Disease;Disease susceptibility;DNA Damage;Doctor of Philosophy;Drug usage;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophagus;Europe;experience;Faculty;follow-up;Funding;Gastric Adenocarcinoma;gastric carcinogenesis;Gastroenterology;Gastroesophageal reflux disease;gastrointestinal;General Population;Genetic;Genomics;graduate student;Health;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;high throughput screening;Home;Human;Human Resources;human tissue;Incidence;Individual;Infection;inhibitor;innovation;Institution;interest;International;Investments;Journals;Laboratories;Latin America;Link;Lipid Peroxidation;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Medical;Medical center;Medicine;member;Mentors;Messenger RNA;Microbiology;Military Personnel;military veteran;Mitochondria;Molecular;Molecular Analysis;Molecular Biology;Morbidity - disease rate;mortality;NADPH Oxidase;Neoplasm Metastasis;novel;novel drug class;novel strategies;Oncogenic;Operative Surgical Procedures;pathogen;Pathology;Pathway interactions;Patients;Pharmacology;Positioning Attribute;Postdoctoral Fellow;Prevention;Production;Productivity;professor;programs;protein degradation;Protein Family;Protein Isoforms;Proteins;Proton Pump Inhibitors;Publications;Publishing;Pump;recruit;Reflux;Reporting;Research;Research Activity;research and development;Research Personnel;Research Training;Risk Factors;RNA Splicing;Scientist;Seminal;Signal Transduction;single-cell RNA sequencing;Soldier;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;statistics;Stomach Neoplasms;Survival Rate;symposium;Techniques;Therapeutic;Time;tool;TP53 gene;Training;Translational Research;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;undergraduate student;United States National Academy of Sciences;United States National Institutes of Health;Universities;upper gastrointestinal cancer;Variant;Veterans;Work


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Age-related neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS) are the most common cause of morbidity in the Veteran population. With no prevention or treatment, individuals with neurodegenerative conditions could reach 11-16 million by 2050. The Head laboratory investigates how caveolin (Cav), a cholesterol binding and scaffolding protein within membrane/lipid rafts (MLRs), regulates synaptic signaling, mitochondrial function, and neuroplasticity in human neurons derived from iPSCs and in animal models of neurodegeneration such as AD and ALS. Recent work from the Head group showed that his patented Cav gene therapy preserves cognitive function in AD mice and improves motor function and extends survival in ALS mice. The findings from this research exhibit strong therapeutic implications for Veterans afflicted with neurodegenerative conditions. Dr. Head’s long-term goal is to translate this gene therapy to the clinical setting to treat Veterans suffering from neurodegenerative conditions.

PI_NAMEs: HEAD, BRIAN P (contact)

PROJECT_TERMS: adeno-associated virus 9 delivery;Afghanistan;Age;age acceleration;age related neurodegeneration;Alzheimer's Disease;Amputation;Amyotrophic Lateral Sclerosis;Animal Model;Award;Biology;Blindness;Brain;Brain Injuries;Capsid;Cardiac;career;caveolin 1;Caveolins;Cells;Central Nervous System;Central Nervous System Diseases;Cerebrum;cholesterol-binding protein;Chronic;Circulation;Clinical;Cognitive;cognitive function;comorbidity;cost;Cyclic AMP;Cytoskeleton;Disease;Dose;Elderly;Engineering;Enhancing Lesion;Exhibits;Face;familial amyotrophic lateral sclerosis;Family;Fellowship;Financial Hardship;functional plasticity;functional restoration;Funding;G Protein-Coupled Receptor Signaling;Gene Delivery;gene therapy;Genetic;Goals;Grant;Growth;Head;Health;Health Care Costs;Healthcare Systems;high risk;Hippocampus;improved;In Vitro;in vitro Model;in vivo;Individual;Induced pluripotent stem cell derived human neuron;injured;Injury;Intervention;Iraq;ischemic injury;Journals;Knowledge;Laboratories;Learning;Legal patent;Longevity;Medical Care Costs;Membrane;Membrane Microdomains;Membrane Proteins;Memory;Mental Depression;Methamphetamine;middle age;military service;military veteran;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Target;Morbidity - disease rate;Morphology;Motor;motor function improvement;Motor Neurons;mouse model;Multiple Trauma;Mus;mutant;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nerve Growth Factor Receptors;Nervous System Physiology;Neurodegenerative Disorders;neuroinflammation;neuromuscular function;Neuromuscular Junction;Neuronal Plasticity;Neurons;neuroprotection;neurotransmission;Neurotransmitter Receptor;neurotrophic factor;novel;old mice;Onset of illness;Outpatients;overexpression;Paper;Patients;pharmacologic;Physical Rehabilitation;Post-Traumatic Stress Disorders;Postdoctoral Fellow;preservation;Prevention;Principal Investigator;promoter;Proteins;Publishing;Rattus;receptor-mediated signaling;Research;Research Peer Review;Research Personnel;Risk Factors;Route;Scaffolding Protein;Scientist;Seminal;Senile Plaques;Signal Transduction;social;social rehabilitation;Spinal;Spinal Cord;spinal cord and brain injury;sporadic amyotrophic lateral sclerosis;State Government;Synapses;Synapsins;synaptic function;Synaptic plasticity;theranostics;Therapeutic;Time;Transgenic Mice;Translating;Trauma;Traumatic injury;Treatment Efficacy;trend;Tropism;United States;United States Department of Veterans Affairs;Veterans;War;Work

PROJECT_TITLE: BLR&D MERIT REVIEW RESEARCH CAREER SCIENTIST AWARD APPLICATION


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Posttraumatic Stress Disorder (PTSD) is a common and debilitating condition among Veterans. While evidence-based treatments have been developed for PTSD, not all patients respond to treatment. Understanding the factors that underlie PTSD symptoms will inform the development of more targeted treatments. Sleep problems are nearly universal in PTSD, as insomnia and nightmares are some of the most commonly reported symptoms following trauma exposure. Preliminary evidence suggests disrupted sleep, especially fragmented Rapid Eye Movement (REM) sleep, impair emotion regulation processes, which may in turn make daytime trauma-related symptoms more severe. However, the potential link between sleep and emotion regulation has not been well explored in clinical groups. This study will investigate the link between disrupted sleep and emotion regulation in Veterans with trauma histories, which will lead to a better mechanistic understanding of PTSD and thus inform the development of better interventions for Veterans.

PI_NAMEs: STRAUS, LAURA D (contact)

PROJECT_TERMS: active control;Acute;Affective;Biological Process;career;Clinical;cognitive reappraisal;cohort;Cohort Studies;comparison control;Cross-Sectional Studies;Data Reporting;design;Development;Diagnostic;Disease;Distress;effective intervention;emotion regulation;Emotional;Emotions;evidence base;Evidence based treatment;experimental study;Goals;Image;imaging system;Impaired cognition;Impairment;indexing;International;Intervention;Laboratories;Link;Literature;longitudinal analysis;Longitudinal Studies;Maintenance;Measures;Mental Health;Methods;Modeling;modifiable risk;Nightmare;Participant;Patient Self-Report;Patients;pharmacologic;physical conditioning;poor sleep;Post-Traumatic Stress Disorders;Process;psychosocial;Questionnaires;Randomized;Recording of previous events;recruit;REM Sleep;REM Sleep Deprivations;Reporting;Research;Research Personnel;response;Risk Factors;Role;Sampling;Severities;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep regulation;Sleeplessness;Slow-Wave Sleep;Stimulus;Symptoms;System;Testing;Time;Training;Trauma;trauma exposure;Validation;Veterans

PROJECT_TITLE: Examining the Effect of Sleep Disruption on Emotion Regulation and Trauma-Related Symptoms in Veterans


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE The lung has a great capacity for healing after illness due to stem cells that repair the distal lung. Some individuals are more vulnerable to lung injury and poor healing, and repair weakens with age. In our work to understand lung repair, we have found that cell metabolism is important to lung healing, and we are working to understand pathways that control cell metabolism after injury as opportunities for enhancing lung repair.

PI_NAMEs: GUTTENTAG, SUSAN H. (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute;Age;Alveolar;alveolar epithelium;Attention;Back;Bioenergetics;Bleomycin;Bypass;Cell Differentiation process;cell injury;Cell model;Cells;Cellular Metabolic Process;Chronic;Coculture Techniques;Communities;Coupled;Data Set;differentiation in vitro;disease model;Distal;Dose;Ear;early onset;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;Event;Exhibits;experimental study;Failure;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;Fostering;Functional disorder;Genes;Genetic Transcription;Glycolysis;Guanosine Triphosphate Phosphohydrolases;healing;healthcare burden;Hermanski-Pudlak Syndrome;Human;Impairment;Individual;Injury;insight;Laboratories;LoxP-flanked allele;Lung;Lung Diseases;lung injury;lung repair;Maintenance;Metabolic;Metabolism;Methods;Mitochondria;Modeling;mouse model;Mus;Mutation;Myofibroblast;Newly Diagnosed;novel;Organ;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Play;Positioning Attribute;postnatal development;Production;Proliferating;Pulmonary Fibrosis;Regulation;repaired;Respiration;response;Role;Signal Transduction;single-cell RNA sequencing;statistics;stem cell expansion;stem cell function;stem cell proliferation;stem cells;Structure;Support Groups;Testing;Validation;Work

PROJECT_TITLE: Metabolic reprogramming of Alveolar Type 2 cells in response to lung injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative The results of this research can be used to inform the experimental and potential therapeutic manipulation of astrocytes and microglia to enhance central nervous system tissue restoration, prevent or attenuate maladaptive neuroinflammation, and bolster repair after nervous system injury, or in neurodegenerative disease.

PI_NAMEs: BURDA, JOSHUA EVAN (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Acute Disease;analysis pipeline;Astrocytes;ATAC-seq;Attenuated;Axon;axonal degeneration;Biological Markers;Cell Nucleus;cell type;Cells;Central Nervous System;central nervous system injury;Characteristics;Chromatin;Chromatin Structure;Chronic;Chronic Disease;CNS degeneration;Communication;Cues;Data;Deterioration;Disease;Disease Progression;Epigenetic Process;Excision;Exhibits;experimental study;Genes;Genetic;Genetic Transcription;human induced pluripotent stem cells;Immune;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Integrins;intercellular communication;Ischemia;Knockout Mice;Lesion;Link;loss of function;Macrophage;Mediating;Methods;Microglia;Modeling;Molecular;Molecular Profiling;Motility;mouse model;Multiple Sclerosis;Mus;Myelin;Nervous System Trauma;Neurodegenerative Disorders;neuroinflammation;Nodule;novel;novel therapeutics;Pathway interactions;Peripheral;Phagocytes;Phagocytosis;Phenotype;prevent;Production;programs;receptor;Recovery;Recovery of Function;recruit;Regulation;Regulatory Pathway;remyelination;repaired;Research;Resolution;response;restoration;Role;Shapes;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Small Nuclear RNA;Specific qualifier value;System;Testing;Therapeutic;therapy development;Time;tissue repair;Tissues;transcriptomics;Transgenic Organisms;tumor microenvironment;Validation;white matter;white matter damage;white matter injury;Work

PROJECT_TITLE: Interrogating a white matter degeneration-specific astrocyte reactivity state and its role in governing repair-associated microglia specification and function.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-G(06)]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

PHR: Dr. Subhra Mohapatra is a recognized leader in research on the molecular and cellular mechanism of Inflammation, which is the central feature of most chronic human diseases, that afflict millions of Veterans. Her major research emphasis has been on using nano- and - biotechnology-based diagnostic and therapeutic approaches to advance the treatment of diverse human diseases, which have already led to clinical studies and/or products in the marketplace. Thus, her Lab at the James A. Haley VA Hospital, Tampa has discovered a few drug targets and packaged them in nanoformulations that are expected to advance the treatment for COVID-19 virus infection-induced lung disease, traumatic brain injury and other neurocognitive diseases, and a variety of cancers including lung, breast, and colorectal cancers, some of which are under clinical evaluation for efficacy.

PI_NAMEs: MOHAPATRA, SUBHRA  (contact)

PROJECT_TERMS: 3-Dimensional;Academy;Acute;acute COVID-19;Affect;Alzheimer's disease related dementia;American;Anti-Inflammatory Agents;Appointment;Area;Artificial Intelligence;Artificial Intelligence enhanced;Award;Biomedical Engineering;Biopsy;Biotechnology;career;CCL20 gene;Cell model;Cell Therapy;Cells;chest computed tomography;Chronic;Chronic Disease;clinical diagnosis;clinical diagnostics;Clinical Research;Clinical Trials;Collaborations;college;Colorectal Cancer;combinatorial;Communicable Diseases;COVID-19;COVID-19 patient;COVID-19 treatment;cytokine release syndrome;Data;Dedications;Dendrimers;Development;Developmental Therapeutics Program;Diagnostic;Disease;Drug Packaging;Drug Targeting;efficacy evaluation;Entrepreneurship;Extramural Activities;Faculty;Florida;Funding;General Population;Graduate Education;Health;Healthcare;Hospitals;Human;human disease;Immunocompetent;improved;In Vitro;in vivo;Incidence;indexing;Individual;Industry Collaboration;Inflammation;inhibitor;innovation;International;Investigation;Journals;Leadership;Legal patent;Licensing;Literature;Long COVID;Lung Diseases;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medicine;Mentors;Mesenchymal Stem Cells;Modeling;Molecular;Molecular Medicine;mouse model;Mus;nano;nanoformulation;nanomedicine;nanoparticle;nanoscale;nanotherapeutic;Nerve Regeneration;Nervous System Disorder;Neurocognitive;Neurodegenerative Disorders;novel;novel diagnostics;novel virus;Oligosaccharides;Oncolytic;pandemic disease;particle;Pathogenesis;Population;prognostic;programs;Property;prophylactic;Publications;Research;Research Activity;research clinical testing;Research Personnel;Research Support;Respiratory Syncytial Virus Infections;Safety;SARS-CoV-2 antiviral;SARS-CoV-2 infection;Scientist;senior faculty;Services;Small Interfering RNA;stem cell therapy;System;Testing;Therapeutic;Therapeutic Research;therapeutically effective;Time;Training;Translational Research;Traumatic Brain Injury;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Veterans;Viral;Viral Respiratory Tract Infection;Virus Diseases;Virus Replication;X-Ray Computed Tomography


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Alcohol use disorder (AUD) and stress-related disorders such as post-traumatic stress disorder (PTSD) constitute a significant health concern for our Veterans. Given that the prevalence of AUD and PTSD comorbidity is especially high in Veterans, the need to better understand how stress interacts with alcohol is critical for developing more effective treatments for this significant health problem. The Becker research program utilizes novel models involving stress and alcohol exposure, along with cutting-edge experimental tools to probe neural mechanisms and brain circuits underlying enhanced alcohol drinking, relapse vulnerability, and cognitive impairments associated with stress and chronic alcohol exposure. The ultimate goal is to provide new insights for developing novel therapeutic interventions that will aid in treatment for individuals suffering from stress and alcohol related disorders - an especially important and clinically relevant problem for our Veteran patients.

PI_NAMEs: BECKER, HOWARD C. (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol relapse;alcohol related problem;alcohol research;alcohol use disorder;Alcohol-Related Disorders;Alcohols;Animal Model;Area;Award;behavioral impairment;Brain;brain pathway;Brain-Derived Neurotrophic Factor;career;career development;Chronic;Chronic stress;Clinical;clinical development;clinically relevant;Cognitive;Collaborations;comorbidity;Complex;Creativeness;Dedications;Disease;Doctor of Philosophy;drinking;Dynorphins;Education;Educational Activities;effective therapy;Ensure;Environment;Ethanol;Evaluation;Exercise;Exposure to;flexibility;forging;Genetic;Goals;Grant;Health;Healthcare;Healthcare Systems;Heavy Drinking;High Prevalence;Impaired cognition;Individual;Infrastructure;innovation;insight;International;Ions;Leadership;Mediating;Medical;Medical center;medical complication;medical schools;Medical Students;member;Mentorship;Mission;Modeling;Molecular;Molecular Biology Techniques;multidisciplinary;Mus;Nature;neural circuit;neurobehavioral;neurochemistry;neuromechanism;Neurons;Neuropeptides;neurotrophic factor;next generation;novel;novel therapeutic intervention;Oxytocin;Patient Care;Patients;pharmacologic;Play;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;pre-clinical;Prevalence;Productivity;programs;Recording of previous events;recruit;Recurrent disease;Relapse;Reporting;Research;research and development;Research Personnel;Research Priority;Research Support;Research Training;Resources;Rewards;Role;Scientist;Services;Sheep;Signal Transduction;Societies;Stress;stress related disorder;Students;success;Symptoms;Therapeutic;tool;Training;Translational Research;treatment strategy;undergraduate student;United States Department of Veterans Affairs;Veterans;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application for Howard Becker, PhD


PHR: Project Narrative Dr. Richards' research examines genetic factors that influence not only population risk, but individual risk, for the unhealthy use of alcohol, methamphetamine and other drugs, including opioids. In 2012, the US National Drug Control Strategy identified active military personnel, Veterans, and their families as populations requiring special support to deal with their drug use problems. In 2022, the same publication reported that the VA is the first organization to implement an evidence-based contingency management “incentives” intervention on a wide-scale that has shown some efficacy. Considerable evidence suggests that mental health disorders are best served by combining psychological and pharmacological interventions. Dr. Richards' research program focuses on genetic and genomic factors that impact initial and continued substance use, as well as the consequences of use. A major goal is to identify individual risk and response mechanisms that could lead to personalized medical advances for addiction and greatly benefit Veteran's health.

PI_NAMEs: PHILLIPS, TAMARA J. (contact)

PROJECT_TERMS: Abstinence;Accounting;addiction;Alcohol dependence;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Alleles;Amines;Animal Genetics;Animal Model;ARHGEF5 gene;Award;Behavioral Mechanisms;Biological Markers;Brain;Breeding;Candidate Disease Gene;career;Chromosome 10;Chronic;chronic alcohol ingestion;Cognitive;Collaborations;Combined Modality Therapy;Consumption;contingency management;craving;CRISPR/Cas technology;Data;differential expression;Disease;Drug Addiction;Drug Controls;drug reward;Drug usage;early experience;Epigenetic Process;Etiology;evidence base;Exhibits;Extracellular Matrix;Family;Funding;Gene Expression;gene network;Genes;Genetic;Genetic Models;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;Genome;Genomics;Genotype;Goals;graduate student;Grant;Health;high risk;Human;Human Genetics;human model;Incentives;indexing;Individual;Individual Differences;individual variation;individualized medicine;Institution;Intake;Intervention;Investigation;Knock-in Mouse;Laboratories;Laboratory Research;Laboratory Technicians;Medical;Mental disorders;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine use;Military Personnel;Modality;Modeling;mouse model;mu opioid receptors;Mus;National Institute on Alcohol Abuse and Alcoholism;neuromechanism;neuropsychiatric disorder;neuropsychopharmacology;neurotoxic;Opioid;Outcome;Pathway Analysis;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Physiological;Population;Population Genetics;Postdoctoral Fellow;postsynaptic neurons;preference;presynaptic neurons;Process;programs;protective effect;Psychiatry;psychologic;Psychological reinforcement;psychosocial;Publications;Quantitative Genetics;receptor;Receptor Gene;Recombinant Inbred Strain;Reporting;Research;Research Design;Research Personnel;Research Project Grants;resilience;response;Rewards;Risk;Risk Factors;Role;Scientist;Sex Differences;Single Nucleotide Polymorphism;Stimulant;substance use;summer internship;Synapses;therapeutic development;therapy development;Toxic effect;trait;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Veterans;Work


PHR: Jie Fan, M.D., has been working at the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice-Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awardees, and a tenured Full Professor of Surgery and Immunology in the Departments of Surgery and Immunology at the University of Pittsburgh. Dr. Fan is a Principal Investigator who has been continuously funded by VA merit review grants since 2007 and NIH research grants (R01, P50, and R56) since 2005. Dr. Fan's research seeks to answer how trauma and sepsis patients develop severe systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), the common causes of death in veterans. Dr. Fan's research is geared toward providing a new understanding of the mechanisms underlying SIRS and ALI and developing novel treatments for SIRS and ALI.

PI_NAMEs: FAN, JIE  (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;American;Area;Autoimmune Diseases;Award;Basic Science;Biological Sciences;Brain Injuries;career;career development;Cause of Death;Cell Death;Cell Differentiation process;Cells;Cessation of life;Chronic;Clinical;clinical investigation;Clinical Research;Collaborations;Communication;Development;Disease;Doctor of Medicine;Doctor of Philosophy;editorial;Education;European;Faculty;Failure;frontier;Functional disorder;Funding;Goals;Government;Grant Review;Health;Healthcare;Healthcare Systems;Hemorrhage;Hepatology;human disease;IACUC;Immunology;Infection;Inflammation;Institution;International;Intervention;Journals;Laboratories;Literature;Medical;Medicine;member;Mentors;military veteran;Molecular;mortality;Natural Immunity;Nature;new therapeutic target;novel;Operative Surgical Procedures;Organ;Paper;Pathogenesis;patient population;Patients;peer;Peer Review;Pharmaceutical Preparations;Phase;Physicians;Play;post-trauma;Postdoctoral Fellow;prevent;preventive intervention;Principal Investigator;Productivity;programs;prophylactic;Publications;Publishing;Reporting;Research;Research Personnel;Research Project Grants;Review Committee;Role;Science;Scientist;senior faculty;Sepsis;septic patients;Signal Transduction;Spinal Injuries;Stroke;Study Section;surgical research;symposium;Systemic Inflammatory Response Syndrome;Therapeutic Intervention;therapy development;Time;Trauma;Trauma patient;United States National Institutes of Health;Universities;Veterans;visiting scholar;Work


ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Parkinson's disease (PD) is the second most prevalent age-related neurodegenerative disorder, after Alzheimer's disease, affecting up to 5% of the population aged 65 – 85 years. Veterans are at increased risk for PD because the veteran population is older than the United States population as a whole and because veterans are more likely to have been exposed to toxic environmental agents during deployment. Current therapies only treat the symptoms of the disease and do prevent or delay its progression. A growing body of evidence from our lab and others has implicated impaired removal of toxic biogenic aldehydes in affected brain areas. Our studies will help to identify drugs that can remove or prevent the accumulation of biogenic aldehydes and alleviate the burden of Parkinson disease in veterans.

PI_NAMEs: STRONG, RANDY  (contact)

PROJECT_TERMS: 4 hydroxynonenal;adduct;Affect;age acceleration;Age Months;age related decline;age related neurodegeneration;age-related disease;aged;agricultural pesticide;aldehyde dehydrogenases;Aldehydes;alpha synuclein;Alzheimer's Disease;Area;Award;Behavioral;behavioral study;Brain;California;career;Clinical;diagnostic biomarker;Disease;Dopamine;dopaminergic neuron;Drug Metabolic Detoxication;environmental agent;epidemiology study;Etiology;Excision;Exhibits;Exposure to;Farming Community;FDA approved;Functional disorder;Gait;Genetic Polymorphism;Human;human old age (65+);Hydralazine;Impairment;in vivo;Isoenzymes;Link;Lipid Peroxidation;Measures;Metabolism;Midbrain structure;Military Personnel;military veteran;Mitochondria;Modeling;Motor;Mus;Mutation;Nerve Degeneration;neurochemistry;neuropathology;neuroprotection;new therapeutic target;overexpression;Parkinson Disease;Patients;Performance;Peripheral;Persons;Pesticides;Pharmaceutical Preparations;Population;preclinical study;prevent;Reducing Agents;Research;Research Support;Risk;Role;Safety;Scientist;sporadic Parkinson's Disease;symptom treatment;Testing;Therapeutic Agents;therapeutic target;Tissues;Toxic Environmental Substances;Transgenic Organisms;United States;Veterans;Work