NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Given that over half of all cancer cases and premature deaths can be prevented, continued advances in cancer prevention and control depend on research that identifies, translates, and implements new knowledge from diverse areas -- from molecular discovery of prevention opportunities to community/provider interventions to increase use of prevention strategies to the adoption of public policy affecting tobacco use and other risk factors. Multidisciplinary training with exposure to a broad spectrum of ideas and mentored collaborative research is fundamental to the development of effective cancer prevention and control researchers. The UNC Lineberger Comprehensive Cancer Center Cancer Control Education Program (CCEP) is a pre- and postdoctoral fellowship training program that prepares fellows for careers in cancer prevention and control that emphasize multidisciplinary and collaborative research. Over the past 30 years, the UNC Lineberger CCEP has successfully trained 122 cancer prevention and control researchers with a multidisciplinary and collaborative focus. Over the next five years, the CCEP will continue its training of the next generation cancer prevention and control researchers.

PI_NAMEs: RIBISL, KURT M. (contact);TROESTER, MELISSA A.

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Control;Education;programs

PROJECT_TITLE: Cancer Control Education Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Kidney Disease;Lung;Prevention;Pulmonary Hypertension

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Pulmonary hypertension is a common cardiovascular complication of end-stage renal disease (kidney failure) which increases the risk of death. This proposal will identify new targets to treat and prevent pulmonary hypertension in these patients. Targets identified by this research will directly lead to clinical trials of new therapies and approaches to improve outcomes for patients with pulmonary hypertension and kidney failure.

PI_NAMEs: EDMONSTON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adverse effects;Affect;Binding;Biology;Blood Vessels;Cardiac Catheterization Procedures;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Chronic Kidney Failure;Circulation;Clinical Investigator;Clinical Trials;cohort;comorbidity;Complication;Data;Dialysis procedure;Dose;Echocardiography;End stage renal failure;Enrollment;Excision;experience;Functional disorder;Future;Genotype;Goals;Grant;Haptoglobins;Hemodialysis;Hemoglobin;Hemolysis;High Prevalence;high risk;Hour;Hypoxemia;Hypoxia;Impairment;improved;improved outcome;individualized medicine;Institution;Intervention Studies;Intervention Trial;Kidney Diseases;Kidney Failure;Lead;Link;Maintenance;Mentorship;Morbidity - disease rate;mortality risk;N,N-dimethylarginine;Nitric Oxide;novel;novel strategies;novel therapeutics;Observational Study;Outcome;Oxygen;Pathogenicity;Patient-Focused Outcomes;Patients;Peripheral;Peritoneal Dialysis;Persons;Positioning Attribute;Preparation;Prevalence;prevent;Principal Investigator;Proliferating;Prospective Studies;Publishing;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;pulmonary vasoconstriction;Pulse Oximetry;Recurrence;Renal function;Research;Respiratory Disease;Risk;Risk Factors;Serotonin;Severities;skills;Sleep Disorders;Smooth Muscle;Testing;Therapeutic;therapeutic target;vasoconstriction

PROJECT_TITLE: Novel Mechanisms and Therapeutic Targets for Pulmonary Hypertension in End-Stage Renal Disease (K23)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Mid-life obesity leads to unhealthy/accelerated brain aging, exacerbating cognitive decline later in life. Yet, the impact of obesity-induced senescence on the cellular components of the neurovascular unit and its functions, including neurovascular coupling, maintenance of blood-brain barrier (BBB) integrity, and microcirculatory network architecture are not understood. Understanding the relationship between brain cellular senescence and impaired BBB function and diminished cerebrovascular hemodynamic responses (which are responsible to maintain intact cognitive function) will be critical to address potential nutritional interventional therapies to avoid obesity-induced cognitive deficits in aging.

PI_NAMEs: TARANTINI, STEFANO  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Abbreviations;Acceleration;Address;age related;Aging;aging brain;aging mechanism;Alzheimer's disease related dementia;American;Astrocytes;Attenuated;Biochemistry;Biometry;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;career development;Cell Aging;cell type;Cells;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Cognition;Cognitive aging;cognitive benefits;Cognitive deficits;cognitive function;cognitive performance;Complex;Confocal Microscopy;contrast imaging;Data;data integration;Dementia;density;Development;Dietary Intervention;DNA Damage;Doctor of Philosophy;Endothelial Cells;endothelial dysfunction;Endothelium;Ensure;Environment;epidemiology study;experimental study;feeding;Flow Cytometry;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Ganciclovir;genetic manipulation;Geroscience;Goals;Grant;Health;hemodynamics;High Fat Diet;Homeostasis;human old age (65+);Hyperemia;Image;Imaging Techniques;Impaired cognition;Impairment;improved;Intervention;intravital imaging;Laboratory Research;Laser Speckle Imaging;Lead;Life;lifestyle intervention;Link;Magnetic Resonance Imaging;Maintenance;Mediating;Mentors;Methods;Microcirculation;Microglia;middle age;Modality;Modeling;Molecular Biology;mouse model;multiphoton imaging;Mus;Muscle Cells;National Institute of General Medical Sciences;network architecture;neuroinflammation;Neurons;neurovascular;neurovascular coupling;neurovascular unit;novel;nutrition;Nutritional;Obese Mice;Obesity;Obesity Epidemic;Oklahoma;old mice;Outcome;Pathogenesis;Pathway interactions;Pericytes;Phenotype;Play;Population;preservation;professor;programs;Proteins;Publishing;Radiation therapy;red fluorescent protein;Regulation;Rejuvenation;Reporter;Research;Research Activity;Research Personnel;Resources;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Shock;skills;success;Techniques;Testing;Therapeutic Intervention;Training;Training Activity;transcriptomics;two-photon;United States;United States National Institutes of Health;Universities;Vascular blood supply;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Work

PROJECT_TITLE: Midlife Obesity, Neurovascular Senescence and Cognitive Decline

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative For cells to heal a wound or form a growing embryo, they have to work together to move coherently. We are creating computer models for how this happens, starting with the ﬁrst step of two cells touching each other and building up to sheets of cells. These models will explain which properties of cells – like their ability to stick to neighbors or their tendency to respond to contact – are most important in this collective motion.

PI_NAMEs: CAMLEY, BRIAN A (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Address;Area;Biochemical;Biological;Biological Assay;Cadherins;Cell Communication;cell motility;Cell Polarity;cell type;Cells;Computer Models;Contact Inhibition;Data;Development;Disease;Embryo;Epithelium;Event;experimental study;Extracellular Matrix;Feedback;Fiber;Future;gastrulation;Geometry;Goals;healing;in vivo;Individual;intercellular communication;Intercellular Junctions;Invaded;Link;Locomotion;Mechanics;mechanotransduction;Microfluidics;migration;model building;Modeling;Molecular;Morphogenesis;Motility;Motion;Motor;Myosin ATPase;Pathologic Processes;physical model;Property;Proteins;Reaction;rho GTP-Binding Proteins;Rupture;Stereotyping;Stream;Study models;Testing;Tissues;tool;Touch sensation;two-dimensional;Work;wound;wound healing

PROJECT_TITLE: Models of collective migration that integrate single-cell polarity and mechanics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Emergency Care;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Wound Healing and Care

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: I. Project Narrative: Smartphone-based wound infection risk screener and care recommender by combining thermal images and photographs using deep learning methods. There is currently no method to diagnose infections in undebrided wounds at the Point of Care (POC) (e.g., in patients’ homes by visiting nurses), resulting in unnecessary referrals to wound clinics and increasing the time to treatment of infections and the likelihood of eventual amputation. To facilitate early and accurate detection of infected wounds at the POC, we propose a smartphone-based screener that jointly analyzes a combination of photographs and a thermal image of a wound using deep learning methods. Our proposed system will detect infections in both debrided and undebrided wounds and recommend evidence-based best care and when to refer infected wounds to experts, standardizing the quality of care provided by non-expert wound caregivers. 1|Page

PI_NAMEs: AGU, EMMANUEL  (contact);GIATSIDIS, GIORGIO

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Affect;Agreement;Algorithms;Amputation;Appointment;Bacteria;beneficiary;Blood Tests;Caregivers;Caring;Cellular Phone;chronic wound;Classification;Clinic;clinical application;clinical decision support;cost;Data Set;Debridement;deep learning;Detection;detector;diabetic;Diabetic Foot Ulcer;Diagnosis;digital health;Emergency Care;Emergency medical service;evidence base;evidence based guidelines;Excision;foot;healing;Home;Home visitation;Hospitals;Image;Image Analysis;improved;Infection;infection risk;Lead;Lighting;limb amputation;Machine Learning;machine learning algorithm;Manuals;Measures;Medicare;Methods;Modeling;novel;Operative Surgical Procedures;Patients;Pattern;Performance;Persons;point of care;Positioning Attribute;pressure;Process;Quality of Care;Quality of life;Recommendation;Recurrence;Redness;Reporting;Research;Resolution;response;Running;Sensitivity and Specificity;Sepsis;Services;Site;smartphone application;Specificity;Standardization;standardized care;success;System;Temperature;Testing;Thermometers;Time;Tissues;Transportation;Trauma;Ulcer;validation studies;Venous;Visit;Visiting Nurse;Visual;wasting;Work;wound;wound care;wound healing;Wound Infection;wound treatment

PROJECT_TITLE: Smartphone-based wound infection screener and care recommender by combining thermal images and photographs using deep learning methods

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Glioblastoma, one of the deadliest primary brain neoplasms, continues to portend a very poor prognosis with a median survival of 14.6 months despite aggressive surgical and medical therapies. Immunotherapeutic approaches have shown promise in improving clinical outcomes, however, known biological features of therapeutic resistance (immune suppression and tumoral hypoxia) are not defined by standard of care gadolinium enhanced magnetic resonance imaging. This translational research and career development proposal will support an early stage investigator in this area of multidisciplinary research to directly address the major challenges of developing life prolonging therapeutic approaches for primary brain tumors; the validation of imaging biomarkers capable of specifically monitoring therapeutic efficacy.

PI_NAMEs: BARAJAS, RAMON FRANCISCO (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acute;Address;Adjuvant;antitumor effect;Anxiety;Area;Biological;Biological Markers;Biometry;Biopsy;brain surgery;California;career;career development;Cell Survival;chemoradiation;Clinic;Clinical;clinical training;clinical translation;clinical trial implementation;Clinical Trials;clinically relevant;collaborative environment;Development;Development Plans;Diagnostic;Diagnostic radiologic examination;diagnostic value;Doctor of Philosophy;Drug Delivery Systems;Early Diagnosis;effective therapy;efficacious treatment;experience;Faculty;ferumoxytol;Flow Cytometry;Funding;Future;Gadolinium;Glioblastoma;Goals;Grant;Growth;Health;Hour;Human;Hypoxia;Image;imaging biomarker;immune activation;Immunohistochemistry;Immunologist;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;Inflammatory;innovation;Interdisciplinary Study;Investigational Therapies;Iron;iron oxide;Knowledge;Laboratories;Life;Magnetic Resonance Imaging;Measures;Mediating;Medical;Mentors;Microglia;Modeling;molecular imaging;Monitor;nanoparticle;Neurobiology;neuroinflammation;Neurologic;Oncology;Operative Surgical Procedures;Oregon;Outcome;patient derived xenograft model;Patients;pembrolizumab;Phagocytes;Phenotype;Physicians;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;premature;Primary Brain Neoplasms;professor;Prognosis;prognostic;prognostic of survival;prognostication;programs;prospective;Radiology Specialty;Rattus;Recurrent disease;Reporting;Research;research and development;Research Ethics;Research Personnel;Resources;response;response biomarker;Review Literature;Role;San Francisco;Science;Scientist;skills;standard of care;Subgroup;Techniques;temozolomide;Testing;Therapeutic;therapy resistant;Time;Tissues;Training;Translating;Translational Research;Treatment Efficacy;treatment response;tumor;tumor hypoxia;tumor immunology;Tumor-associated macrophages;tumor-immune system interactions;Uncertainty;Universities;Validation;Work;Writing

PROJECT_TITLE: Defining the Hypoxic Immunosuppressive Microenvironment as a Biomarker of Therapy Efficacy in Glioblastoma Using Iron Oxide Enhanced FMISO PET/MRI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PUBLIC HEALTH RELEVANCE Maternal mental illness can adversely modify the developmental trajectory of the child and is a significant contributor to maternal mortality in the U.S. A significant portion of women can experience traumatic childbirth, and some will develop posttraumatic stress disorder (PTSD), although this condition remains underdiagnosed and undertreated. This study will define the course and predictors of maternal childbirth-related PTSD and its effects on the child and lay the foundation for preventive and holistic care for both mother and child.

PI_NAMEs: DEKEL, SHARON  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Accidents;Address;Affect;American;American College of Obstetricians and Gynecologists;Animal Model;antenatal;assault;Behavioral;Biological;Biological Markers;Birth;Breast Feeding;candidate identification;Caring;Child;Child Development;Child Welfare;Childbirth;Chronic;Clinical;Cognition;Cognitive;cohort;combat;Communication;cost;Data;Development;Diagnosis;Dimensions;Discipline of obstetrics;Disease;DSM-V;Early Intervention;early screening;Emotional;emotional distress;Enhancers;Epigenetic Process;ethnic health disparity;Ethnic Origin;experience;Exposure to;Foundations;Goals;Growth;Health;health disparity;Hour;Imagery;Impairment;improved;Infant;infant temperament;insight;intergenerational;Investigation;Knowledge;Knowledge acquisition;Life;longitudinal, prospective study;low socioeconomic status;Maternal Deprivation;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Mediating;Medical;Medical Records;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental imagery;Military Personnel;Minority Women;Mission;Modification;Morbidity - disease rate;Mother-Child Relations;Mothers;Motor;National Institute of Child Health and Human Development;neonatal period;Neurotic Disorders;obstetrical complication;Outcome;patient stratification;Perception;Perinatal;Physiological;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;prepregnancy;prevent;Preventive;Procedures;Productivity;programs;prospective;protective factors;Provider;Psyche structure;psychologic;Psychometrics;Psychopathology;Psychophysiology;public health relevance;Quality of Care;racial discrimination;racial health disparity;Recommendation;Reduce health disparities;Reproductive Process;response;Risk;Risk Factors;Role;Schedule;screening;Security;social determinants;Social support;societal costs;Standardization;stem;Stress;stressor;Symptoms;Testing;Therapeutic Intervention;Third Pregnancy Trimester;Time;tool;Trauma;trauma exposure;traumatic event;traumatic stress;Validation;welfare;Well in self;Woman;Work

PROJECT_TITLE: Defining postpartum PTSD and its implications for maternal wellness and child development

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative (Public Health Relevance Statement) The proposed project will elucidate the development of categorization and category learning -- critical components of typical cognitive development. Because the ability to learn and use categories is changed or reduced under various forms of intellectual and/or developmental disability, such as autism or Williams syndrome, understanding of typical development is critical for better and more precise diagnosis of these developmental disorders. Therefore, results of the proposed research may contribute to the early diagnostics (and potentially treatment) of autism and Williams syndrome.

PI_NAMEs: SLOUTSKY, VLADIMIR M (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 4 year old;9 year old;Adult;Affect;Age;age difference;Attention;autism spectrum disorder;Award;Canis familiaris;Categories;Child;Cognition;cognitive development;Color;comparison group;Computer Models;Data;design;Development;Developmental Disabilities;developmental disease;Diagnosis;Diagnostic;Dimensions;Disparate;Exhibits;Experimental Models;experimental study;Eye;gaze;Goals;Human;Intellectual functioning disability;Intelligence;Joints;Knowledge;knowledge network;Learning;lexical;Link;Longitudinal Studies;Memory;Methodology;Mind;Modeling;older adult;Participant;Pattern;Performance;Persons;Property;public health relevance;Reaction Time;Research;research and development;Research Personnel;Role;selective attention;Semantics;Series;Shapes;statistical learning;statistics;Stimulus;Structure;Testing;Time;tool;Training;transfer learning;Williams Syndrome;young adult

PROJECT_TITLE: The Development of Categorization

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: PROJECT NARRATIVE A genome-wide association study (GWAS) analyses the genomes of many people to find genetic variations associated with a particular disease or trait; associations are reported in the scientific literature and require standardisation to allow researchers to use and analyse them, for example to calculate Polygenic Scores which provide a calculation of relative risk of developing a disease. Our work provides fundamental knowledge and infrastructure to enable rapid storage, presentation, quality control and use of this knowledge and is used by academic researchers and pharmaceutical companies for the benefit of human health

PI_NAMEs: INOUYE, MICHAEL ;PARKINSON, HELEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Address;Architecture;Area;Atlases;Automation;base;biobank;Biomedical Research;Border Crossings;Cardiovascular Diseases;Catalogs;Charities;cloud based;Collaborations;Communities;Complex;computational platform;Consent;Data;data access;data acquisition;Data Analyses;Data Element;data exploration;data ingestion;data integration;data quality;Data Reporting;Data Set;database of Genotypes and Phenotypes;Deposition;design;Diabetes Mellitus;Disease;distributed data;diverse data;Ensure;Equity;Ethics;Evaluation;exome;experience;Feedback;feeding;Future;Genes;genetic association;Genetic Variation;genome analysis;genome resource;genome sequencing;genome wide association study;genomic variation;Genomics;graphical user interface;Health;Human;improved;Infrastructure;International;Journals;Knowledge;knowledge base;large datasets;Legal;Link;Literature;machine learning algorithm;Malignant Neoplasms;Mental disorders;Metadata;Methods;Mission;Modeling;novel;Online Systems;Ontology;Performance;Persons;Pharmacologic Substance;Population;portability;Prevention;Privacy;Process;Quality Control;Randomized;Relative Risks;Reporting;Reproducibility;Research;Research Personnel;resilience;Resource Development;Resources;Scoring Method;Source;Standardization;statistics;Structure;Surveys;Techniques;text searching;Time;tool;Training;trait;Translating;Translations;Update;Variant;Visualization;web site;whole genome;Work;working group

PROJECT_TITLE: Strengthening community knowledge bases for genetic association studies and polygenic scores, the GWAS and PGS Catalogs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Tetraspanins are an ancient and exceptionally well-conserved family of transmembrane proteins that have essential but poorly understood functions in many different cellular contexts. This work will provide a deep understanding of how the tetraspanin CD81 modulates signal transduction by the B cell co-receptor, and how C8 tetraspanins influence ADAM10 metalloprotease function. These findings will inform future therapeutic efforts targeting these important processes.

PI_NAMEs: BLACKLOW, STEPHEN C. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: alpha secretase;Alzheimer's Disease;Amyloid beta-Protein;ascorbate;Auditory system;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;beta secretase;Binding;Biochemical;Biological;Biological Assay;Biological Process;CD19 gene;CD81 gene;Cells;Chemicals;Common Variable Immunodeficiency;Complex;Coupled;CRISPR/Cas technology;Cryoelectron Microscopy;Cysteine;cytokine;Defect;Development;Disease;Dissection;Dissociation;Event;extracellular;Family;Family member;Follow-Up Studies;Foundations;Future;Genitourinary system;Goals;Human;Human Biology;Immune system;inhibitor;insight;Integral Membrane Protein;Investigation;Knock-out;Knowledge;Label;Ligands;loss of function mutation;Low affinity IgE receptor;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Metalloproteases;Molecular;Mus;nanoenvironment;notch protein;Organism;Output;Pathway interactions;Peptide Hydrolases;Peroxidases;Phosphorylation;Physiological;Physiology;Positioning Attribute;Process;Production;Protein Precursors;Proteins;receptor;Receptor Signaling;Regulation;Reproductive system;Resolution;response;Role;Signal Transduction;Signal Transduction Pathway;spatiotemporal;Spices;Stimulus;Structure;Structure-Activity Relationship;T-Cell Proliferation;T-Cell Receptor;Therapeutic;Time;trafficking;Visualization;Work

PROJECT_TITLE: Structure and Function of Tetraspanin Complexes

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This relevance of this proposal centers on illuminating the mechanisms by which carcinomas develop resistance to cancer-directed therapy via the process of transdifferentiation. The successful completion of this project will yield fundamental information delineating how cells are capable of altering their lineages and phenotypes, and will identify new treatment strategies to overcome treatment-induced resistance.

PI_NAMEs: NELSON, PETER S (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;advanced prostate cancer;Aggressive Clinical Course;androgen deprivation therapy;Androgen Receptor;Automobile Driving;Biological Process;BRAF gene;cancer therapy;Carcinoma;cell growth;Cell Lineage;Cell Survival;Cells;Characteristics;Clinical;design;Development;Environment;Epidermal Growth Factor Receptor;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;Exhibits;Human;inhibitor;Invaded;Lung Adenocarcinoma;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;Mesenchymal Differentiation;Metastatic Prostate Cancer;Morphology;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;Oncogenes;Oncogenic;Pathway interactions;Patients;permissiveness;Phase;Phenotype;pressure;prevent;Process;Prostate;Receptor Signaling;Research Proposals;Resistance;Resistance development;response;Signal Pathway;Specific qualifier value;stem cells;stemness;Stress;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy development;therapy resistant;tissue repair;Tissues;transdifferentiation;Tumor Promotion;Work

PROJECT_TITLE: Targeting Vulnerabilities Exposed by Cancer Treatment-Induced Lineage Plasticity

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition that causes enormous human suffering and cost to society. Our goal is to rapidly learn more about the genetics of this disorder and how genes and environment might act and interact to alter disease risk. We propose to do this by collecting a new, large, ancestrally-diverse and well-phenotyped sample of OCD cases followed by detailed genomic analyses.

PI_NAMEs: CROWLEY, JAMES JOSEPH (contact);MATTHEISEN, MANUEL ;PATO, MICHELE T

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Area;Argentina;autism spectrum disorder;Bioethics;Biological;Biology;Bipolar Disorder;Brazil;Chile;Chronic;Clinic;Clinical;cohort;Cohort Studies;Collaborations;Colombia;comorbidity;cost;cost effective;Data;design;Detection;Diagnosis;Dimensions;Disease;disorder risk;Disparity;DNA;Ecuador;Environment;Equity;Etiology;European ancestry;follow-up;Functional disorder;Funding;Future;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genetic study;Genome Mappings;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;health disparity;high risk;Human;improved;Individual;Knowledge;Latin America;Latin American;Latinx;Learning;Linkage Disequilibrium;Maps;Measures;Mental disorders;Mental Health;Meta-Analysis;Mexico;neuropsychiatry;novel;Obsessive-Compulsive Disorder;Online Systems;Outcome;Pathway interactions;Patients;Performance;Phenotype;phenotypic data;polygenic risk score;Population;precision medicine;Prevention strategy;psychiatric genomics;Public Health;recruit;Reduce health disparities;Risk;risk variant;Saliva;Sample Size;Sampling;Schizophrenia;Science;screening;Severities;societal costs;Societies;Specialist;Structure;Symptoms;Testing;Training;Variant;Work;working group

PROJECT_TITLE: 1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In this application I propose a career development plan to transition me to an independent scientist. I propose to define the mechanisms by which the type 1 diabetes PTPN2 risk-allele contributes to loss of anergy in B cells during the pathogenesis of disease. The overarching goal of these studies is to better understand how genetic factors contribute to type 1 diabetes by altering the status of autoreactive anergic B cells in hopes of translating findings into novel therapeutic targets to treat the disease.

PI_NAMEs: SMITH, MIA  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Acute;Advisory Committees;Affect;Affinity;Alleles;anergy;Antigen Presentation;Antigen Receptors;Antigen-Presenting Cells;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B-Lymphocytes;Beta Cell;Binding;career development;CD80 gene;CD86 gene;Cell Compartmentation;Cells;Clonal Deletion;Complex;Cytometry;Development;Development Plans;Diabetes Mellitus;diabetic;Disease;Disease Resistance;Environmental Risk Factor;First Degree Relative;Frequencies;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genome wide association study;Genotype;Goals;high risk;HLA Antigens;Human;Hyperglycemia;Immune Tolerance;Impairment;Inbred NOD Mice;Individual;instructor;Insulin;Insulin-Dependent Diabetes Mellitus;insulitis;Knowledge;Lead;lymph nodes;Lymphocyte;Maintenance;Memory;Mentors;Messenger RNA;mouse model;Mus;new therapeutic target;novel therapeutics;Pancreas;Pathogenesis;Patients;Peripheral;Phenotype;Plasmablast;Prediabetes syndrome;prevent;Production;Productivity;Proliferating;Proteins;Publications;receptor;Research;Resistance;response;Risk;risk variant;Role;Scientist;Signal Transduction;Single Nucleotide Polymorphism;skills;Structure of beta Cell of islet;T-Lymphocyte;Technology;Training;Translating

PROJECT_TITLE: Genetic contribution to loss of B cell anergy during development of type 1 diabetes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE  Invading pathogens, such as Salmonella enterica serovar Typhimurium (S. Tm), must outcompete the resident microbiota to establish infection in the intestines. The proposed research will investigate how inflammation facilitates S. Tm intestinal growth by allowing the pathogen to exploit metabolic interactions with commensal Bacteroides spp. This work will challenge the dogma that Bacteroides-derived metabolites are inhibitory to S. Tm and provide a deeper understanding of how S. Tm thrives in the gut.

PI_NAMEs: BYNDLOSS, MARIANA XAVIER (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Amino Acids;antimicrobial;Aspartate;Bacteria;Bacteroides;Bacteroides thetaiotaomicron;Catabolism;Citric Acid Cycle;colonization resistance;commensal bacteria;commensal microbes;Cytolysis;Data;diarrheal disease;Ecosystem;enteric pathogen;Enterobacteriaceae;Epithelial Cells;Escherichia coli;essays;experimental study;Fluorescence Microscopy;Fumarates;Gastroenteritis;Gastrointestinal tract structure;Genes;Genetic Transcription;Germ-Free;Growth;gut inflammation;gut microbiota;host microbiota;In Vitro;in vivo;Infection;Inflammation;innovation;intestinal epithelium;Intestines;Invaded;Measures;Mediating;Metabolic;Metabolism;microbial;microbiota;mouse model;Mus;mutant;Nitrates;non-typhoidal Salmonella;novel;Nutrient;Oxidants;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phase;Physiology;Play;Production;Propionates;Reactive Oxygen Species;Reporter;Research;resident commensals;Respiration;response;Role;Salmonella;Salmonella typhimurium;Source;Study models;Taxon;Testing;Type III Secretion System Pathway;United States;Virulence;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: JACKSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative: The incidence of hypertensive cardiovascular remodeling and arterial stiffness is increasing at an alarming rate with no cure, it is therefore urgent to identify potential therapeutic targets that can reduce the high mortality rate of hypertensive cardiovascular remodeling and arterial stiffness. Emerging evidence suggests endothelial/pericyte interactions and NG2 pericytes may be novel targets for the treatment of hypertensive cardiovascular remodeling and vascular stiffness. The proposed studies will reveal how endothelial oxygen sensor PHD2 and glycolytic metabolic reprogramming regulate endothelial/pericyte interactions and NG2 pericyte recruitment in hypertensive vascular remodeling and arterial stiffness, and will create a new platform for drug discovery for hypertensive cardiovascular remodeling and vascular stiffness.

PI_NAMEs: CHEN, JIAN-XIONG  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: angiogenesis;Angiotensin II;Aorta;ARG2 gene;arginase;arterial remodeling;arterial stiffness;Attenuated;Basement membrane;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;BMP2 gene;bone morphogenetic protein 9;calcification;Cardiovascular system;Cells;Clinic;clinical translation;Coronary;CSPG4 gene;Data;Death Rate;Differentiated Gene;Differentiation Antigens;Disease;drug discovery;Endothelium;Etiology;Fibroblasts;Fibrosis;Functional disorder;Heart;Hypertension;hypertensive;Incidence;inhibitor;Kidney;Knock-out;Lung;Maintenance;Mediating;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Molecular;Mus;Myofibroblast;NOTCH3 gene;novel;Osteoblasts;osteogenic;osteopontin;Outcome;Oxygen;Pericytes;pharmacologic;Procollagen-Proline Dioxygenase;Production;Pulmonary Hypertension;recruit;Regulation;Reporter;Reporting;Role;sensor;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Source;Tertiary Protein Structure;Testing;therapeutic target;Thick;Up-Regulation;Vascular calcification;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Endothelial PHD2 in hypertensive vascular remodeling

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: RELEVANCE TO PUBLIC HEALTH: NACDA promotes a better understanding of health and the promotion of health behaviors by collecting data and research information on the aging lifecourse. This information is reprocessed and then distributed from the NACDA website, providing a large and growing set of research tools to facilitate the study of disease, aging and overall health. This project will facilitate multidisciplinary research using longitudinal data focused on conative functioning and Alzheimer’s research.

PI_NAMEs: MARCOTTE, JOHN EDWIN (contact);MCNALLY, JAMES W

PROGRAM_OFFICER_NAME: KRUPENEVICH, REBECCA LYNN

PROJECT_TERMS: Acceleration;Address;Adoption;age acceleration;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Archives;Area;Basic Science;Behavioral Research;Bibliography;Cataloging;Clinical Research;Cognition;Collection;Common Data Element;Communities;comorbidity;computerized;COVID-19 complications;COVID-19 risk;Data;Data Analyses;Data Collection;data infrastructure;data integration;data interoperability;data management;data portal;data preservation;data resource;data sharing;Democracy;Development;digital;Disease;Documentation;Educational process of instructing;Educational workshop;effective intervention;Extensible Markup Language;flexibility;Foundations;Gerontology;Goals;Growth;Health;Health behavior;Health Promotion;improved;Individual;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;interoperability;Knowledge;Life Cycle Stages;Longitudinal Studies;Metadata;Mission;Modeling;National Archive;operation;Outcome;outreach;Phase;Play;pro-aging;Process;Public Health;Quality of life;repository;Research;Research Infrastructure;Research Personnel;Resources;Role;Science;Secondary to;Services;social media;Standardization;Structure;symposium;Techniques;therapy development;tool;Training;Training and Education;United States National Institutes of Health;usability;web site;webinar;Work

PROJECT_TITLE: FACTORS IN AGING: Best Practices in Archiving and Sharing Interoperable Longitudinal Data Resources on Aging


NIH_SPENDING_CATS: Cardiovascular;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The vasculature is a network of tubes with different but characteristic diameters that delivers life- sustaining circulation everywhere in our body. Blood vessels with abnormally wide or narrow openings, either due to a genetic defect or an acquired condition like plaque buildup, cannot carry proper blood flow, leading to decreased cardiovascular health and even death. This study studies how Plxnd1, a protein found at the surface of the cells lining the blood vessels, ensures that blood vessels acquire the right caliber.

PI_NAMEs: TORRES-VÁZQUEZ, JESÚS  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: 3-Dimensional;Address;Adherent Culture;Adult;Anatomy;Animals;Apical;Area;Arteries;Atherosclerosis;base;Binding;Biological Models;Blood Circulation;Blood flow;Blood Vessels;Caliber;Cardiac;Cardiac Myocytes;cardiovascular health;Cell Line;Cell surface;cerebral cavernous malformations;Cessation of life;Characteristics;Circulation;Data;Defect;Development;Diameter;Dissection;Embryo;Endothelial Cells;Endothelium;Ensure;Excision;Exhibits;experimental study;Fishes;Genes;Genetic;Genetic Transcription;Heart;Hemorrhage;Hereditary hemorrhagic telangiectasia;Human;In Vitro;in vivo;Inherited;Knowledge;Life;Ligands;Mammals;Measures;mechanotransduction;Mediating;Messenger RNA;Molecular;morphometry;Mus;mutant;Mutation;Myocardial;novel;Organ;overexpression;Pattern;Play;plexin;Process;Property;Proteins;receptor;Regulation;Reporter;Role;Semaphorins;Shapes;shear stress;Side;Signal Pathway;Signal Transduction;System;Testing;Tissues;Trees;Troponin T;Tube;Vascular Diseases;Veins;Ventricular;Visualization;Zebrafish

PROJECT_TITLE: Mechanistic bases of vessel diameter regulation by Plexind1 - Resubmission

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Mental Illness;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Sleep Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Psychological stress is a potentially major risk factor for sudden cardiac death and can cause cardiac electrical instability. This study aims to address the reasons behind sudden cardiac death by evaluating the relationship of cardiac electrical instability with posttraumatic stress disorder (PTSD). We will also study the way in which PTSD-related genes, sleep disturbance, and physical inactivity may also play a role in its potential relationship with cardiac electrical risk.

PI_NAMEs: SHAH, AMIT JASVANT (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;Acute;Acute Post Traumatic Stress Disorder;Address;adjudication;Age;Area;Arrhythmia;Attenuated;Autonomic Dysfunction;Autopsy;behavior influence;Behavioral;Behavioral Mechanisms;biobehavior;Brain;Cardiac;Cardiac Electrophysiologic Techniques;Cardiomyopathies;Cardiovascular system;Chronic;Chronic Post Traumatic Stress Disorder;clinical diagnosis;cohort;Collaborations;Communities;Coronary heart disease;cost;Country;Data;design;Diagnosis;Ecological momentary assessment;Electrocardiogram;Event;experience;Exposure to;Feasibility Studies;Funding;Future;General Population;Genes;Genetic;Health Technology;Heart;Heart Diseases;heart rate variability;Heterogeneity;Home;improved;indexing;Individual;innovation;International;Interview;Investigation;Lead;Machine Learning;maladaptive behavior;male;Measures;Medical center;men;Methodology;Methods;mHealth;modifiable behavior;Monitor;Monozygotic twins;Morphology;mortality risk;multidisciplinary;Natural experiment;novel;Outcome;Participant;participant enrollment;Physical activity;physical inactivity;Pilot Projects;Polysomnography;poor sleep;Post-Traumatic Stress Disorders;Prevalence;prospective;Protocols documentation;Psyche structure;Psychological Stress;psychological trauma;Publications;recruit;Recurrence;Registries;Research;Research Design;Research Personnel;Risk;Risk Factors;Risk Marker;Sampling;Savings;sedentary lifestyle;Sex Differences;signal processing;Site;Sleep;sleep behavior;Sleep disturbances;Sleep Fragmentations;Social Distance;Stress;sudden cardiac death;Symptoms;Tachyarrhythmias;Techniques;telehealth;Time;traumatic stress;Travel;Twin Multiple Birth;Twin Studies;United States;United States Department of Veterans Affairs;Ventricular;Veterans;Vietnam;Viola;virtual;Women's study;Work;wristband

PROJECT_TITLE: Association of Posttraumatic Stress Disorder with Cardiac Electrical Instability: A Twin Study

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_DEPT: SURGERY

PHR: This application seeks ongoing funding for our T32 training program, “Clinical and Laboratory Research Training for Surgical Oncologists,” currently completing its ninth year of funding. The program provides sophisticated clinical and research training to highly selected surgical residents and surgical oncology fellows, preparing them for leadership roles in academic surgical oncology.

PI_NAMEs: CAMERON, ANDREW M. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Clinical Research;Laboratory Research;Research Training;Surgical Oncologist


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Kidney Disease;Precision Medicine;Sepsis

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is the most common form of organ failure in sepsis and sepsis-induced AKI is associated with prolonged hospitalization, need for renal replacement therapy, and death; however, no effective pharmacotherapy exists for the treatment of sepsis-induced AKI. We have shown the presence of two distinct AKI sub-phenotypes with different 1) clinical and molecular characteristics, 2) outcomes, 3) genetic risk and 4) response to therapeutics. This application will determine whether these or alternative AKI sub-phenotypes are present in the emergency room, whether AKI sub-phenotypes respond differently to volume of intravenous fluids, and whether differences in kidney histopathology and urinary proteomics exist between sepsis-induced AKI sub-phenotypes.

PI_NAMEs: BHATRAJU, PAVAN KUMAR (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;aptamer;Biological;Biological Markers;Biopsy;Blood;Blood capillaries;candidate marker;career;Cessation of life;Characteristics;Clinical;clinical care;clinical risk;Clinical Treatment;Clinical Trials;Critical Care;Critical Illness;crystalloid;Data;Dialysis procedure;disorder risk;endothelial dysfunction;Funding;Genetic Risk;Heterogeneity;high risk;Histologic;Histology;Histopathology;Hospital Mortality;Hospitalization;Hour;improved;Inflammation;innovation;Intervention;IV Fluid;Kidney;kidney biopsy;Lesion;Liquid substance;Measures;Modeling;Molecular;Molecular Epidemiology;Multicenter Trials;multidisciplinary;Nephrology;novel;Organ failure;Outcome;Patient Care;Patients;Pattern;personalized approach;Pharmacotherapy;Phenotype;Plasma;Population;Positioning Attribute;pre-clinical;precision medicine;prevent;Process;prognostic;prospective;Prospective Studies;Proteins;Proteomics;Public Health;Qualifying;Randomized;Recovery;Renal Replacement Therapy;Reproducibility;Research;Research Personnel;response;Resuscitation;Risk;risk stratification;Sample Size;Sepsis;Septic Shock;SP1 gene;Structure;Syndrome;Testing;Therapeutic;Time;Tissues;Translating;treatment response;trial enrollment;United States National Institutes of Health;unsupervised clustering;urinary;Urine;Validation;Vasoconstrictor Agents;Vasopressins

PROJECT_TITLE: Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical Outcomes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE A comprehensive genome-wide identification of cell type-specific gene regulatory elements and gene expression in human cells is of critical importance for understanding how genomic variation impacts human health and disease. We propose to develop an IGVF Mapping Center that utilizes our recent development of high- throughput genome-wide technologies to simultaneously map open chromatin sites, gene and protein expression, and clonal lineage tracing in single cells from human tissues during development, adult health, and several disease conditions, including cancer, neurodegeneration, infection, and autoimmunity. We will work closely with the IGVF Consortium to share technologies, resources, data, and human samples towards the goal of understanding the relationship between functional element-cell type associations and genome function.

PI_NAMEs: CORCES, MICHAEL RYAN;SATPATHY, ANSUMAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Adopted;Adult;Age;Alzheimer's Disease;Atlases;Autoimmune Diseases;Autoimmunity;biobank;Biological Assay;Body System;Bone Marrow Cells;Catalogs;Cell Lineage;Cell surface;Cell Surface Proteins;cell type;Cells;Chromatin;combinatorial;Communities;Computational Biology;Computing Methodologies;Consent;cost;cost efficient;Data;data integration;data quality;data sharing;Development;Disease;DNA;DNA mapping;Elements;epigenome;epigenomics;experience;Functional disorder;Gene Expression;Generations;Genes;Genetic Transcription;genetic variant;Genome;genome-wide;genome-wide analysis;Genomic approach;genomic variation;Genomics;Goals;Health;healthy aging;high throughput technology;Homeostasis;Human;Human Development;human disease;Human Genetics;human tissue;Immune;Immune system;improved;indexing;Individual;Infection;Insulin-Dependent Diabetes Mellitus;Life;Link;Malignant Neoplasms;Maps;Measurement;Metadata;Methods;Mission;Mitochondria;multimodality;multiple omics;Multiple Sclerosis;Mutation;National Human Genome Research Institute;Nerve Degeneration;Neurodegenerative Disorders;Organ;Patients;peripheral blood;Play;protein expression;Proteins;Protocols documentation;Regulator Genes;Regulatory Element;Research;Research Personnel;Resolution;Resources;Role;Sampling;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Site;Systemic Lupus Erythematosus;Techniques;Technology;Tissue Sample;Tissues;Work

PROJECT_TITLE: Single-cell Mapping Center for Human Regulatory Elements and Gene Activity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE  Millions of people are infected with Toxoplasma gondii and we propose to validate new targets for improved chemotherapy. The mitochondrion of T. gondii and of other apicomplexan parasites is critical for their replication and several major antiparasitic drugs act through inhibition of the mitochondrial electron transport chain. Our studies will lead to the discovery of new mitochondrial enzymes that are essential for parasite growth and for which specific inhibitors could be developed.

PI_NAMEs: MORENO, SILVIA N (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute infection;Allergic Reaction;Anabolism;Antiparasitic Agents;atovaquone;bisphosphonate;Bone Diseases;Cells;Central Nervous System;Chemicals;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;chronic infection;Clinic;Clinical;Congenital Toxoplasmosis;Country;Cryptosporidiosis;Cyst;cytotoxicity;Data;Diphosphates;Disease;drug action;Drug Kinetics;Drug Targeting;Drug usage;effective therapy;Electron Transport;Electron Transport Complex III;Electrons;Enzymes;experience;Eye diseases;farnesyl pyrophosphate;Fetus;fosmidomycin;Future;gene complementation;Genetic;geranylgeranyl diphosphate;Geranyltranstransferase;Growth;Head;HIV;Human;hydroxybenzoate;hypercholesterolemia;Immunocompetent;Immunocompromised Host;Immunosuppression;improved;In Vitro;Infection;inhibitor;inorganic phosphate;Isomerism;isopentenyl pyrophosphate;isoprenoid;knock-down;Laboratories;lipophilicity;Malaria;Mammalian Cell;member;Membrane;mevalonate;Mitochondria;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;opportunistic pathogen;Organ Transplantation;Outcome;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Plants;Population;Pregnancy;Property;Quinolones;Quinones;Research;Resistance;shikimate;small molecule libraries;Supplementation;Tail;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;Toxoplasma gondii;Toxoplasmosis;Treatment Failure;Ubiquinone;ubiquinone 6;Validation;Water;Work;Yeasts

PROJECT_TITLE: Validation of the ubiquinone synthesis pathway of Toxoplasma gondii as a novel drug target

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-R(02)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Pregnancy;Social Determinants of Health;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based treatment for PTSD in usual care obstetrics settings, and patient-level barriers to engagement such as stigma. The proposed study is a randomized controlled trial, which will examine the effectiveness of a brief evidence-based treatment for PTSD (i.e., Written Exposure Therapy) during pregnancy and the non-inferiority of delivery of this treatment by community health workers vs. delivery by mental health clinicians. Results will inform future efforts aimed at improving access to and quality of care for treatment of PTSD during pregnancy.

PI_NAMEs: NILLNI, YAEL I (contact)

PROJECT_TERMS: active control;addiction;Address;adverse pregnancy outcome;Affect;Aftercare;behavioral health;Black race;Boston;brief intervention;care preference;Caring;Characteristics;Clinic;Clinical;Cognitive;Communities;Community Health Aides;Data;depressive symptoms;design;Discipline of obstetrics;Discrimination;Dropout;Effectiveness;effectiveness evaluation;effectiveness testing;Emotions;ethnic diversity;ethnic minority population;Ethnic Minority Women;evidence base;Evidence based treatment;Feasibility Studies;follow-up;Future;future implementation;Health Disparities Research;Health Personnel;hospital care;Hospitals;Impairment;implementation barriers;implementation trial;Improve Access;Individual;Infant;Intervention;Interview;Length;long-term sequelae;Low Birth Weight Infant;Low income;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Medical;Medical center;member;Memory;Mental Depression;Mental Health;Minority;Minority Women;New England;obstetric care;Outcome;Participant;patient engagement;patient-level barriers;Patients;perceived discrimination;Perinatal;perinatal mental health;perinatal period;perinatal women;personalized approach;Population Heterogeneity;Post-Traumatic Stress Disorders;Postpartum Depression;postpartum outcome;Postpartum Period;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prevent;Process;process evaluation;Provider;psychiatric symptom;psychological symptom;psychosocial;Publications;Quality of Care;Race;racial diversity;racial minority population;racial minority women;racism;Randomized;Randomized, Controlled Trials;recruit;Research;Risk;safety net;scale up;screening;service utilization;social stigma;Specialist;Stigmatization;Stress;Supportive care;Surveys;Symptoms;System;system-level barriers;Testing;Time;Training;Trauma;treatment as usual;treatment disparity;United States National Institutes of Health;Vision;Visit;Woman;Writing

PROJECT_TITLE: A Non-Inferiority Trial Testing Delivery of Written Exposure Therapy by Community Health Workers for Treatment of PTSD During Pregnancy

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Our future ability to fight infectious disease depends on advanced training of students so that they gain the analytical skills needed to investigate these diseases in ways that emphasize the complexities of interactions between the pathogen, host, and microbiome. Our trainees will receive exceptional academic mentoring and professional development training from our dedicated, highly experienced, and accomplished faculty working in this area. This includes diverse trainers and trainees and will include activities where trainees mentor the next generation of scientists from populations typically underrepresented in science.

PI_NAMEs: CARBONETTI, NICHOLAS H;DUNNING HOTOPP, JULIE  (contact);RASKO, DAVID A

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: microbial;Pathogenesis;Research;System

PROJECT_TITLE: Systems-Level Research in Microbial Pathogenesis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Alzheimer’s disease is a pressing healthcare issue for our healthcare system and the more than five million patients and families affected by the disease. This research will help understand how changes in the circadian clock contribute to worsening neuronal function, contributing to our understanding of the disease’s cause and potentially uncovering new strategies for prevention or treatment.

PI_NAMEs: GAMBLE, KAREN L;ROBERSON, ERIK D (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Ablation;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Area;Behavioral;Bioinformatics;bioinformatics pipeline;Cell Physiology;Cells;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;comparison group;Data;dentate gyrus;design;designer receptors exclusively activated by designer drugs;Development;Disease;Diurnal Rhythm;Electrophysiology (science);epileptiform;Event;excitatory neuron;Exhibits;experimental study;Family;fighting;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Healthcare;Healthcare Systems;Hippocampus;Human;human model;Impaired cognition;Impairment;inhibitory neuron;innovation;insight;Interneurons;Intervention;Investigation;Knock-in;Knowledge Portal;Ligands;LoxP-flanked allele;Mediating;Membrane;Molecular;molecular clock;mouse model;Mus;neural;neuroimaging;neuronal excitability;Neurons;neurophysiology;Parvalbumins;patch clamp;Pathogenesis;Pathology;Patients;Pattern;Periodicity;pharmacologic;Phase;Physiology;postsynaptic;Predisposition;Prevention strategy;Property;Prosencephalon;Regulation;Research;response;Seizures;single molecule;Slice;tau Proteins;Testing;Time;tool;transcriptome sequencing;transcriptomics;translating ribosome affinity purification and RNA-sequencing;Variant;Wild Type Mouse

PROJECT_TITLE: Circadian changes in network excitability and Alzheimer disease pathogenesis


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The brain is a major regulator of metabolism, regulating food intake and energy expenditure through activity level and thermogenesis; meanwhile, the immune system has been shown to play a role in regulating many important metabolic organs, such as the liver, muscle, and fat depots. Whether the immune system can affect neuronal regulation of metabolism remains unclear. This project will investigate the role of IL-13, an immune- signaling protein whose receptor gene has been implicated in obesity, in modulating the central regulation of metabolism, in order to identify new treatment options for obesity and type II diabetes management.

PI_NAMEs: CHALOM, MAYER MARC (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Biogenesis;blood glucose regulation;Body mass index;Brain;Brain region;Cell Nucleus;Cells;combat;Cues;cytokine;Cytokine Signaling;Data;diabetes management;Dopamine;dopaminergic neuron;Eating;energy balance;Energy Metabolism;Enzymes;Exhibits;Fasting;Fatty acid glycerol esters;food consumption;Food Energy;gain of function;Gene Deletion;Gene Expression;Genetic Models;Genetic study;genomic locus;Glucose Intolerance;glucose metabolism;Helper-Inducer T-Lymphocyte;Hemorrhage;Homeostasis;Hormones;Human;Hyperphagia;Hypothalamic structure;IL13RA1 gene;Immune;Immune signaling;Immune system;Immunity;Infiltration;Inflammation Mediators;Inflammatory;Insulin Resistance;insulin sensitivity;Interleukin-1 beta;Interleukin-13;Interleukin-4;Knock-out;Knowledge;LacZ Genes;Lead;Leptin;Lesion;Link;Liver;loss of function;Lymphoid;Macrophage;Mediating;Membrane;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;Midbrain structure;Modeling;Molecular;Mus;Muscle;Nervous System;Neurons;NFKB Signaling Pathway;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obesity;Organ;Overnutrition;pandemic disease;Pathologic;Pathway interactions;Peripheral;Pharmaceutical Preparations;Phenotype;Population;Production;receptor;Receptor Gene;Regulation;Reporting;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stains;Substantia nigra structure;Testing;Thermogenesis;Tissues;TNF gene;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Weight Gain

PROJECT_TITLE: Interleukin-13 in Central Regulation of Metabolism


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vaccine Related;Vector-Borne Diseases

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Understanding the mechanism of attenuation of the highly successful yellow fever 17D live attenuated vaccine is critical to improving its safety and for the development of safe vaccines for other flaviviruses. In the prior funding period, we discovered a critical role for type I interferon (IFN) in the attenuation mechanism and found that mutations in the type I IFN receptor genes, IFNAR1 and IFNAR2, as well as autoantibodies to type I IFNs, underlie some cases of severe adverse reactions to 17D vaccination. Here, using a variety of novel approaches, we propose to define the mechanisms by which type I IFN and innate immune responses influence viral replication, spread and cytotoxicity of the attenuated 17D and virulent Asibi yellow fever virus strains.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: A549;Adverse reactions;Affinity Chromatography;Amino Acid Substitution;Amino Acids;Attenuated;Attenuated Vaccines;attenuation;Autoantibodies;Biological Assay;Cell Cycle Kinetics;Cell Line;Cell secretion;Cells;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;cytotoxicity;Data;Development;Disease;Disparate;DNA Sequence Alteration;Dose;E protein;Epidemic;Event;fitness;Flavivirus;Fluorescent in Situ Hybridization;Funding;Genes;Genetic Transcription;genome-wide;Goals;Hepatocyte;HepG2;IFNAR1 gene;IFNAR2 gene;imaging modality;Immune;Immune response;Immunocompetent;improved;in vivo;Individual;Infection;Infection prevention;innate immune pathways;Innate Immune Response;insight;Integration Host Factors;Interferon Receptor;Interferon Type I;Interferons;Kinetics;Knock-out;Label;Libraries;Life;Link;Lipids;Lung;Maps;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;mimetics;Mosquito-borne infectious disease;mutant;Mutation;mutation screening;Natural Immunity;Nervous System Disorder;neurotropic;new therapeutic target;novel strategies;Outcome;pathogen;Patients;Pattern recognition receptor;Persons;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Predisposing Factor;prevent;Prevention;Prevention approach;Prevention strategy;Process;prophylactic;Proteins;Proteomics;Receptor Activation;Receptor Gene;reconstitution;Resolution;response;RNA;RNA replication;Role;Safety;Sampling;Serious Adverse Event;Signal Pathway;South Africa;South America;STAT1 gene;Testing;Transcript;transcriptome sequencing;Translations;treatment strategy;type I interferon receptor;Vaccination;vaccine adverse event;vaccine development;Vaccines;Viral;Viral Proteins;viral RNA;Virulent;Virus;Virus Diseases;Virus Replication;Work;Yellow Fever;Yellow Fever Vaccine;Yellow fever virus;Yellow Fever Virus Infection

PROJECT_TITLE: Unraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The goal of this project is to develop novel computational methods to jointly analyze 3D chromatin organization data and 1D epigenomic features, and reveal the interplay among regulatory elements, epigenomic features, and dynamic chromatin organization. These new methods will help us understand the mechanisms of the genetic variants identiﬁed in genome-wide association studies, and understand the genetic basis of many human diseases.

PI_NAMEs: LIU, JIE  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Base Pairing;Cell Line;Cell Nucleus;cell type;ChIP-seq;Chromatin;Computer Models;Computing Methodologies;Data;Data Set;deep learning;Disease;DNA Sequence;Elements;Epigenetic Process;epigenome;epigenomics;experimental study;Genetic;genetic variant;Genetic Variation;Genome;genome annotation;genome wide association study;Genomics;Goals;Hi-C;human disease;Human Genome Project;Joints;Maps;Measures;Methods;novel;Nucleosomes;Regulatory Element;Resolution;Signal Transduction;Three-dimensional analysis;transcription factor;Transcriptional Regulation;Untranslated RNA;Work

PROJECT_TITLE: Joint analysis of 3D chromatin organization and 1D epigenome


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Pre-exposure prophylaxis (PrEP) is effective at reducing the acquisition of HIV; however, achieving the full impact of this intervention is contingent on keeping patients engaged in care throughout periods of high and low risk. HIV risk changes over time and a person’s reasons for engagement, disengagement, and re- engagement in care are not well understood, but likely change over time. In this project, we propose to utilize self-reported and clinical data to elucidate reasons for very early disengagement (<2 visits after initiation), early disengagement (2-4 visits after initiation), and late disengagement (>4 visits after initiation) and use machine learning methods to design predictive models for disengagement from HIV prevention care.

PI_NAMEs: ZUCKER, JASON  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adherence;Affect;African American;AIDS prevention;Area;Behavior;Behavioral;Bioinformatics;care fragmentation;Caring;Clinical;Clinical Data;clinical trial analysis;Computer Assisted;Computerized Medical Record;cost;Data;Databases;design;Development;Enrollment;Epidemic;Female;follow-up;Future;Health;health care disparity;Health care facility;Health Care Visit;health data;health determinants;Health Personnel;high risk;HIV;HIV risk;Housing;improved;Individual;information organization;insight;Institution;Insurance;Insurance Coverage;Intervention;Investigation;Latino;Lead;Machine Learning;machine learning method;men who have sex with men;Mental Health;Mentors;Modeling;modifiable risk;Motivation;New York;New York City;patient engagement;Patient Self-Report;Patients;Perception;Persons;Population;pre-exposure prophylaxis;predictive modeling;Presbyterian Church;Prevention;Prevention program;prevention service;programs;prospective;Provider;Questionnaires;Research;Resources;Risk;Risk Factors;Schedule;Services;Site;skills;social;Structure;substance use;Text Messaging;Time;Training;transgender;United States;Visit

PROJECT_TITLE: Harnessing Bioinformatics for HIV Prevention: Understanding Persistence in Comprehensive HIV Prevention Services

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The prevalence of youth vaping has grown substantially in the past decade, but knowledge of the drivers and consequences remains limited. Expanding this knowledge base is critical to developing effective interventions, which presently are lacking. We propose to leverage the unique ABCD cohort to (1) identify modifiable risk factors predicting e-cigarette use during childhood and adolescence, including social, contextual, and individual factors; (2) identify neurocognitive and health consequences of youth e-cigarette use; and (3) evaluate whether a causal relationship exists between e-cigarette and combustible tobacco use. Findings would aid development of prevention and intervention programs to reduce e-cigarette use and provide key information to agencies charged with regulatory decisions about e-cigarettes.

PI_NAMEs: DORAN, NEAL  (contact);JACOBUS, JOANNA

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Abstinence;Address;Adolescence;Adolescent;Affective;Age;airway inflammation;Animals;authority;Behavioral;Brain;Cardiovascular Diseases;Cells;Cessation of life;Characteristics;Charge;Child;Childhood;Chronic;Cigarette;Cigarette Smoker;cigarette smoking;Clinical;Cognitive;Cognitive deficits;cohort;combustible tobacco;Communities;Conflict (Psychology);Consumption;Crime;Data Set;Dependence;design;Development;Devices;Disease;DNA;e-cigarette aerosols;effective intervention;Electronic cigarette;electronic cigarette use;emotion regulation;Expectancy;Exposure to;Family;Formulation;Friends;Goals;gut inflammation;Health;High Prevalence;High School Student;Home;Human;Individual;Inhalation;interest;Intervention;intervention program;JUUL;Knowledge;knowledge base;Learning;Life;Longitudinal cohort study;Lung Diseases;Marketing;Metabolic Diseases;Middle School Student;modifiable risk;Morbidity - disease rate;Morphology;mortality;Nature;Neighborhoods;neural;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Nicotine;Nicotine Dependence;nicotine exposure;Outcome;parental monitoring;Pattern;peer;peer influence;Physiological;Policies;Policy Maker;Population;Predictive Factor;Predisposition;Prevalence;Prevention;Prevention program;programs;prospective;prospective test;psychologic;Psychological reinforcement;reduce tobacco use;repaired;Research;Risk;Risk Factors;Safety;Self Efficacy;social;social media;Sodium Chloride;System;Testing;therapy development;Time;Tobacco;Tobacco Dependence;tobacco products;Tobacco use;uptake;vaping;Work;Youth

PROJECT_TITLE: Vaping in Childhood and Adolescence: Cognitive and Behavioral Consequences

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Prostheses can be suspended from the amputated limb using a variety of techniques, such as straps and suction. Suspending the prosthesis by creating a vacuum between the prosthetic socket and limb using a pump has benefits over other techniques including improved limb health and mobility. While most pumps are electrical or mechanical, this project will develop and test a new pump that combines both systems to eliminate the limitations of each independent system. We will design a new mechanical pump and combine it with a computer-controlled electrical pump. We will discuss this pump with clinicians and prosthesis users to understand their opinion on the technology. The pump design will be tested to confirm that it works properly and is safe to use, and then will be used by prosthesis users in the laboratory to verify its functionality. This pump will be appropriate for Veterans with leg amputations of different ages and activity levels by creating a reliably secure connection to the prosthesis while reducing the need to charge the battery.

PI_NAMEs: MAJOR, MATTHEW J. (contact)

PROJECT_TERMS: Address;Age;Amputation;Area;battery life;battery recharging;Charge;clinical efficacy;Clinical Research;commercialization;Computers;Consultations;Department of Defense;design;Development;Devices;Disadvantaged;Ensure;Esthetics;Evaluation;fabrication;falls;Feedback;Focus Groups;Funding;Future;gait symmetry;Gender;Generations;healing;Health;Housing;human subject;Hybrids;improved;in vivo;Individual;Industrialization;industry partner;insight;interest;Knee;Laboratories;Leg;Legal patent;limb amputation;limb loss;Limb Prosthesis;Limb structure;manufacture;Manufacturer;Market Research;Marketing;Mechanics;Methodology;Microprocessor;Monitor;Motion;Noise;older patient;Patients;Persons;Positioning Attribute;pressure;Process;Prosthesis;prosthesis wearer;prosthetic socket;prototype;Pump;Reaction;Research Proposals;residual limb;Respiratory Diaphragm;seal;Secure;success;Suction;Suspensions;System;Techniques;Technology;Technology Transfer;Testing;Time;Universities;Vacuum;Vacuum Pumps;Veterans;Veterans Health Administration;Walking;walking performance;Work;wound

PROJECT_TITLE: Hybrid Electrical-Mechanical Pump for Vacuum Suspension of Prosthetic Sockets

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Despite high efficacy, oral preexposure prophylaxis (PrEP) has had a limited population-level impact on HIV incidence in the U.S., in part because of challenges with pill-taking. Long-acting injectable PrEP is highly effective and could improve adherence and persistence, but its impact will depend on implementation in a context where oral PrEP is already an option. This research will investigate real-world use, clinical outcomes, and optimal investment of resources to facilitate the implementation of long-acting injectable PrEP, with the goal of maximizing impact and equity.

PI_NAMEs: MARCUS, JULIA L. (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Adherence;Affect;AIDS prevention;Benchmarking;black men who have sex with men;black women;Budgets;California;cis-female;Clinical;clinical practice;Continuity of Patient Care;cost;cost effectiveness;Data;data modeling;data platform;Decision Modeling;Detection;Development;Drug resistance;Economic Models;Economics;Effectiveness;Electronic Health Record;Epidemic;Epidemiology;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;Focus Groups;Funding;Gender;Goals;Half-Life;Healthcare Systems;high risk;HIV;HIV Infections;Implant;implementation design;implementation facilitation;implementation strategy;improved;Incidence;Inequity;Infrastructure;Injectable;Injections;innovation;interest;Intervention;Investments;Laboratories;Latino;Maryland;mathematical model;member;men who have sex with men;Methods;Modality;Oral;Outcome;Participant;Persons;Phase;phase III trial;pill;Policies;Population;pre-exposure prophylaxis;Prevention strategy;Provider;Qualitative Methods;Race;racial disparity;racial diversity;Ramp;Research;Research Design;Research Infrastructure;Resource Allocation;resource guides;Resources;Risk;Sampling;Testing;therapy development;transgender women;Translations;Treatment Failure;underserved community;Underserved Population;United States National Institutes of Health;uptake;Viral Load result;Virginia;Visit;Work

PROJECT_TITLE: Cabotegravir PrEP: Actionable Robust Evidence for Translation into Practice (CABARET)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative. Many people with mental disorders suffer from drastic mood swings, which can escalate to the point of despair and even attempting suicide. This work will help understand the brain and behavior processes that underlie mood swings; if successful, this study will help clinicians predict mood swings using phone apps and wearable sensors.

PI_NAMEs: DOMBROVSKI, ALEXANDRE Y. (contact);ELDAR, ERAN PLAYFAIR;HALLQUIST, MICHAEL NELSON

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Affective;Anterior;Anxiety Disorders;Behavior;Behavioral;Brain;Clinical;cognitive neuroscience;college;Color;Communities;Computer Models;Corpus striatum structure;Coupling;Data;Data Collection;Diagnostic;Dimensions;dynamic system;Eating Disorders;Ecological momentary assessment;Electroencephalography;Elements;expectation;experimental study;Feedback;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;Heart Rate;Hour;Image;improved;indexing;Individual;insight;Insula of Reil;Laboratory Study;Learning;Life;Link;Mediating;Mediator;Mental Depression;Mental disorders;Methods;mobile computing;Modeling;Moods;motivational processes;negative mood;neural;neural circuit;neuroimaging;neuromechanism;neurophysiology;Outcome;Personality;Personality Disorders;Persons;Physiological;Physiology;Population;positive mood;Positive Valence;Prefrontal Cortex;Process;Protocols documentation;Psychological reinforcement;Psychopathology;recruit;Research Domain Criteria;response;Rewards;Role;Safety;Sampling;Scanning;Schedule;sensor;Shapes;Signal Transduction;Stimulus;suicidal behavior;Suicide attempt;System;Systems Theory;Telephone;Testing;theories;Time;tool;Variant;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivity


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Nutrition;Obesity;Orphan Drug;Prevention;Prostate Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases;Women's Health Research

PHR: Project Narrative The process by which normal cells turn into cancer cells requires changes in stem-like cells that are present in all organs. Our environment, life style and genetics all play roles in creating local inflammation that drives the transformation of normal stem cells into cancer cells. The Early Phase Clinical Prevention Consortium plans to identify and test drugs that interrupt these processes with a goal of ultimately reducing mortality from cancer.

PI_NAMEs: DJURIC, ZORA ;SCHUETZE, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Address;Alcohols;Antibodies;Automobile Driving;Back;Biological Markers;Biology;biomarker driven;Bladder;Breast;breast density;cancer cell;Cancer Center;cancer prevention;Cancer Prevention Trial;cancer risk;cancer stem cell;carcinogenesis;CDC2 gene;cell type;cellular targeting;Chemicals;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;Colon;Colon Carcinoma;Conduct Clinical Trials;cytokine;Data;design;Dose;drug repurposing;drug testing;dysbiosis;early phase clinical trial;early phase trial;Ensure;Environment;Epidemic;Epigenetic Process;Epithelial Cells;Epithelium;Esophageal Tissue;Esophagus;experience;Funding;Genes;Genetic;Genetic Polymorphism;Genitourinary system;Goals;Grant;high risk population;high throughput technology;human tissue;immune activation;In Situ;Individual;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;Infrastructure;Institution;Interruption;Iron Chelation;JAK1 gene;Lead;Letters;Life Style;Link;Logistics;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mesenchymal;Metabolic;Metabolic syndrome;Methodology;Methods;Michigan;microbial;Molecular;Molecular Target;mortality;Neoplasms;neoplastic;New Agents;Normal Cell;novel;novel strategies;Obesity;Obesity associated cancer;obesity prevention;operation;Organ;Organizational Affiliation;Oxidative Stress;Participant;participant retention;Pathway interactions;Patient Recruitments;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;phase III trial;Play;preclinical study;prevent;Prevention;Prevention strategy;Prevention trial;Preventive;Process;progenitor;programs;Proliferating;promoter;Prostate;Protocols documentation;receptor;Regulation;Resources;response;Role;Safety;Sampling;Schedule;Science;self-renewal;Site;Solid Neoplasm;sound;Source;Speed;STAT3 gene;stem cell population;stem cell proliferation;stem cell self renewal;stem cells;stem-like cell;stemness;Stress;synergism;System;targeted agent;Technology;Testing;Therapeutic;Therapeutic Index;Tissue Sample;Tissues;trial design;tumor initiation;Universities;Vision

PROJECT_TITLE: Early Phase Clinical Cancer Prevention Consortium


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: We propose to develop a light-sheet light-field tomography (light-sheet LIFT) method for kilohertz 3D imaging of electromechanical coupling in zebrafish hearts undergoing atrial fibrillation (AF). The knowledge so obtained will be instrumental in elucidating AF's fundamental mechanism from the electrical activities at a single-cell level.

PI_NAMEs: GAO, LIANG  (contact);HSIAI, TZUNG K

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TITLE: Kilohertz 3D Optical Mapping of Atrial Fibrillation in Beating Zebrafish Hearts

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Endocrine Disruptors;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The developing nervous system is very sensitive to myriad environmental chemical exposures that arise as complex mixtures. We are proposing one of the first longitudinal studies of neurodevelopmental consequences of complex, time varying metal-organic interactions during fetal and early childhood development.

PI_NAMEs: ARORA, MANISH  (contact);WRIGHT, ROBERT O

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Age;Apatites;Biochemical;Biological;Biological Markers;Birth;Blood;Chemical Exposure;chemical reduction;Chemicals;Child;Childhood;Cities;Cognition;cognitive development;cohort;Collection;Complex;Complex Mixtures;cost effective;Data;deciduous tooth;Dental;design;Development;Dose;early childhood;early life exposure;early pregnancy;Elements;Environment;environmental chemical;environmental chemical exposure;environmental stressor;epidemiology study;executive function;exposed human population;Exposure to;fetal;Foundations;Future;Grant;Growth;Health;high dimensionality;Individual;infancy;innovation;intergenerational;Knowledge;Laboratories;Life;Longitudinal Studies;Measures;Metal exposure;Metals;Methodology;Methods;Mexico;Modeling;Nervous System;Neurocognitive;neurodevelopment;Neurodevelopmental Deficit;neurotoxicology;New York City;novel;Obesity;offspring;Organic Chemicals;Participant;Perinatal;Perinatal Exposure;perinatal period;Phenotype;phenotypic data;phthalates;pollutant;Poly-fluoroalkyl substances;preadolescence;Predisposition;Pregnancy;prenatal;prenatal exposure;Preparation;Property;prospective;Prospective Studies;Prospective, cohort study;Recording of previous events;recruit;repository;Research;Research Design;research study;Risk;sample collection;Sampling;Second Pregnancy Trimester;Short-Term Memory;social stressor;Statistical Methods;statistics;Stress;Sum;Techniques;Testing;theories;Third Pregnancy Trimester;Time;tool;Tooth structure;toxicant;Toxicant exposure;Trace Elements;Urine;Work

PROJECT_TITLE: Organic-metal mixtures and neurodevelopment

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative This Program will train young scientists to become leaders in the use of complex data analysis and machine learning algorithms to transform the massive data sets generated by high-throughput experimental technologies into knowledge and action in areas ranging from personalized medicine and drug discovery to structural biology and microbial ecology. They will also learn how to recognize and ameliorate algorithmic and racial bias in the generation and application of data so that the benefits derived from improvements in public health and the treatment of human disease are distributed equitably.

PI_NAMEs: BENSON, GARY E.;SEGRE, DANIEL  (contact);TULLIUS, THOMAS D

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: Predoctoral Training in Bioinformatics and Computational Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a mean survival rate of only 3-5 years. Surprisingly few therapeutic treatments exist given the severity of this disease and no treatment improves survival rates. We propose to engineer new biomaterials that incorporate synthetic components and natural lung proteins to build 3D in vitro models of fibrotic disease, modified by exposure to light to replicate key aspects of the disease not otherwise reproducible in current models, advancing discovery of new targets for treatment.

PI_NAMEs: MAGIN, CHELSEA M (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Age;Alveolar;alveolar epithelium;Animal Model;antifibrotic treatment;Architecture;Atomic Force Microscopy;Biocompatible Materials;Biological;biomaterial compatibility;Cell Communication;Cell Culture Techniques;Cells;Chronic;Clinical;Collagen;Data;Deposition;design;Diagnosis;Disease;Distal;drug discovery;drug efficacy;Elderly;Encapsulated;Engineering;Epithelium;ethylene glycol;Experimental Designs;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;fibrotic lung;Foundations;Functional disorder;Gases;Goals;Histology;Human;human disease;human model;human tissue;Hybrids;Hydrogels;idiopathic pulmonary fibrosis;Image;improved;In Situ Hybridization;In Vitro;in vitro activity;in vitro Model;innovation;Laboratories;Life;Light;Location;Lung;Lung Diseases;mechanical properties;Mechanics;Mediator;Medical;Mesenchymal;Methods;Microfabrication;Modeling;Modulus;Molecular;Morbidity - disease rate;mortality;Mus;new therapeutic target;novel;Output;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Platelet-Derived Growth Factor alpha Receptor;Population;Positioning Attribute;pre-clinical;Precision therapeutics;programs;protein expression;Proteins;Pulmonary Fibrosis;Reaction;Reporter;Reproducibility;Research Personnel;Respiratory Failure;response;Rheology;screening;Severity of illness;Signal Pathway;Smooth Muscle;Source;spatiotemporal;Stains;Statistical Data Interpretation;Structure;Structure of parenchyma of lung;Survival Rate;System;targeted treatment;Technology;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;Type II Epithelial Receptor Cell;Vertebral column;Work

PROJECT_TITLE: Hybrid Hydrogel Biomaterials Comprising Clickable Decellularized Extracellular Matrix for Engineering Dynamic 3D Models of Fibrosis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Depression and anxiety are the leading causes of disability and lost productivity and are often underdiagnosed and undertreated due to access, cost, and stigma barriers, highlighting the pressing need for novel means of treatment delivery with the potential of reaching many who otherwise would not have access to mental health services. To address this unmet need, this project will develop a voice-enabled, artificial intelligence (AI) agent named Lumen, trained in Problem Solving Therapy (PST) and accessible on secure study iPads. The project will rigorously test the effects of Lumen on brain circuits affecting emotional reactivity and cognitive control, which are related to depressive and anxiety symptoms; results will have high potential for significant clinical and public health impact.

PI_NAMEs: AJILORE, OLUSOLA A.;MA, JUN  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: active control;active method;Address;Adult;Affect;Amygdaloid structure;Anxiety;anxiety symptoms;Area;arm;Artificial Intelligence;Attitude;behavioral health intervention;Brain;chatbot;Clinical;clinical decision support;Cognition;Cognitive;cognitive control;Computer software;connected care;coping;cost;depressive symptoms;Development;Devices;Diagnosis;digital medicine;disability;Dorsal;Dose;efficacy testing;Eligibility Determination;Emotional;emotional distress;Emotions;Engineering;Enrollment;Evaluation;experience;Focus Groups;follow up assessment;formative assessment;Functional disorder;Functional Magnetic Resonance Imaging;Future;Generalized Anxiety Disorder;Health;Health Promotion;Health Resources;Human;Image Analysis;improved;innovation;insight;intelligent agent;iterative design;knowledge base;Lateral;Learning;Length;Machine Learning;Measurement;Measures;Mediating;meetings;Mental Depression;Mental Health;Mental Health Services;Moods;Names;neural;neural circuit;neuromechanism;Neurosciences;new technology;novel;Outcome;Participant;participant enrollment;Patient Outcomes Assessments;Patient Self-Report;Patients;Personal Satisfaction;Persons;Phase;pilot test;Prefrontal Cortex;Problem Solving;problem solving therapy;Procedures;Process Measure;Productivity;Professional counselor;Protocols documentation;prototype;Psychotherapy;Public Health;Quality of life;Questionnaires;Randomized;randomized, clinical trials;recruit;Research;Secure;social stigma;Specific qualifier value;Stress;Surveys;Symptoms;targeted treatment;Techniques;Testing;theories;Therapeutic;Time;Training;Translating;treatment arm;Treatment Efficacy;treatment optimization;United States National Institutes of Health;usability;user centered design;virtual;virtual health;Voice;Voice Training;Waiting Lists;Walking

PROJECT_TITLE: Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults with Emotional Distress


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Mutations in the Progranulin (GRN) gene have been causally linked to frontotemporal lobar degeneration (FTLD) and single nucleotide polymorphism (SNP) in GRN has been implicated as a risk factor for Alzheimer's disease (AD). To provide mechanistic insights for cellular senescence in Grn-/- microglia and determine how Grn-/- microglia contribute to neurodegeneration, we have developed innovative strategies that use single cell transcriptomics and quantitative proteomics to provide molecular and physiological properties that promote glial activation and neuronal degeneration caused by Progranulin deficiency. Our results will provide unprecedented clarity on disease mechanism in FTLD and AD.

PI_NAMEs: HUANG, ERIC J (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: aging brain;Alzheimer's Disease;Alzheimer's disease risk;Amino Acids;Behavior;brain tissue;Cell Aging;cell motility;Cells;Complement 1q;Complement 3b;Defect;Disease;dominant genetic mutation;early onset;Exhibits;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Genes;glial activation;Gliosis;GRN gene;Hippocampus;Homeostasis;Human;innovation;insight;Integrin alphaV;Integrin alphaVbeta3;Integrins;ITGB3 gene;Knock-in Mouse;Knock-out;Knockout Mice;Link;Mediating;Microglia;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;Natural Immunity;Nerve Degeneration;Neuroglia;neuron loss;Neurons;neuropathology;neurotoxicity;Obsessive-Compulsive Disorder;Pathology;Pathway interactions;Patients;PGRN gene;Phagocytosis;Phenotype;Physiological;programs;Property;protein TDP-43;Proteomics;Publishing;Risk;RNA-Binding Proteins;Role;senescence;Signal Transduction;Single Nucleotide Polymorphism;Stable Isotope Labeling;synaptic pruning;Testing;TGF Beta Signaling Pathway;Thalamic structure;therapeutic target;Toxic effect;transcriptomics;Transforming Growth Factor beta;Up-Regulation;Vesicle;Work

PROJECT_TITLE: Progranulin deficiency and microglia senescence in neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative The distinct features of obesity and diabetes associated cardiomyopathy are extensive accumulation of lipid droplets (LDs) in myocardium together with increased incidence of heart failure. Currently, in human heart, the cellular system and molecular mechanism for LD transport still remain elusive. This proposal will uncover a novel human long non-coding RNA (lncRNA) HL6-mediated LD transport system in human cardiomyocytes, and test the cardioprotective role of HL6 against metabolic syndrome associated cardiomyopathy in vitro and in in vivo.

PI_NAMEs: YANG, LEI  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3-Dimensional;Adult;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;cardioprotection;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoskeleton;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;diabetic patient;Dimensions;Disease;Down-Regulation;Engineering;Fatty Acids;feeding;Functional disorder;Future;Genetic Transcription;Goals;Heart;Heart failure;heart function;heart preservation;High Fat Diet;Human;human induced pluripotent stem cells;human pluripotent stem cell;Impairment;In Vitro;in vitro Model;in vivo;Incidence;insight;Knock-out;Laboratories;Lipid Binding;lipid metabolism;Lipids;long chain fatty acid;Mediating;Membrane;Metabolic syndrome;Mitochondria;mitochondrial dysfunction;Mitochondrial Swelling;Modeling;Molecular;monolayer;Mus;Mutation;Myocardial dysfunction;Myocardium;non-muscle myosin;non-muscle myosin heavy chain-B;Nonmuscle Myosin Type IIB;novel;Obesity;overexpression;oxidation;Patients;Pharmaceutical Preparations;Phenocopy;Phospholipids;Play;Proteins;Research;RNA;Rodent Model;Role;System;Testing;Tissues;Transgenes;Transgenic Mice;Transgenic Organisms;translational potential;Type 2 diabetic;Untranslated RNA

PROJECT_TITLE: Deciphering a Novel LncRNA-mediated Lipid Droplet Transport System in Human Heart

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]