NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The proposed research aims to understand patient preferences for differentiated service delivery (DSD) programs among people living with HIV and examine the impact of preference-concordant DSD programs on clinical outcomes, quality of life, and progress toward controlling the HIV epidemic in Kenya. The results of this work will inform the design of more patient-centered DSD programs and policy decision-making in Kenya and other high HIV burden settings.

PI_NAMEs: KIM, HAE-YOUNG  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Adherence;Adopted;Affect;Africa South of the Sahara;antiretroviral therapy;Area;Berry;career;career development;Caring;Categories;Characteristics;Client;Clinic;Clinic Visits;Clinical;Communities;community based care;comparative cost effectiveness;comparative effectiveness;Continuity of Patient Care;cost;cost effective;Country;Decision Making;design;Disclosure;dissemination science;Education;Eligibility Determination;Environment;Epidemic;Epidemiology;Evaluation;experience;experimental study;Goals;group counseling;Guidelines;Health;Health care facility;HIV;Home;Human Resources;implementation science;improved;Individual;Institution;International;Intervention;Kenya;low and middle-income countries;mathematical model;Measurement;Measures;medical schools;men;Mentored Research Scientist Development Award;Mentorship;Observational Study;Outcome;outreach;patient oriented;Patient Preferences;Patient-Focused Outcomes;Patients;Persons;Policies;Population;preference;Privacy;Privatization;programs;prospective;Prospective, cohort study;Provider;Psychosocial Factor;Qualitative Research;Quality of life;Research;Research Personnel;Research Project Grants;Science;service delivery;Services;skills;social;social stigma;Social support;South Africa;Statistical Methods;Structure;Study models;symposium;Training;transmission process;treatment adherence;treatment group;Viral;Viral Load result;Work;World Health Organization;Zambia

PROJECT_TITLE: Investigating the impact of preference-concordant differentiated service delivery for HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung;Precision Medicine;Prevention;Pulmonary Fibrosis;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: MARTINEZ, FERNANDO J (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Age;airway epithelium;airway obstruction;Alveolar Macrophages;Ancillary Study;Basic Science;biobank;Biological;Biological Markers;Biology;Blood;Bronchoalveolar Lavage;Bronchoscopy;Characteristics;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Cigarette Smoker;Clinical;clinical care;clinical database;clinical diagnosis;clinical investigation;cohort;Collaborations;Cross-Sectional Studies;Data;Data Aggregation;Data Set;data standards;Development;Disease;disease diagnosis;disease heterogeneity;disorder subtype;DNA;Early Diagnosis;Ensure;Epidemiology;Epithelial Cells;ethnic minority population;Female;Fibrosis;follow-up;former smoker;Foundations;Funding;Genetic;Goals;Human;human population study;idiopathic pulmonary fibrosis;Image;improved;Individual;Injury;Institution;International;Interstitial Lung Diseases;Investigation;Link;longitudinal analysis;Longitudinal, observational study;Lung;lung volume;Metadata;Molecular;National Heart, Lung, and Blood Institute;new therapeutic target;non-smoker;Observational Study;Pathogenesis;Pathway interactions;patient registry;Patients;Phenotype;phenotypic data;Physiological;Physiology;Plasma;Population;Predisposition;Prevention program;Probability;prospective;Pulmonary Emphysema;Pulmonary Fibrosis;Radiology Specialty;Recording of previous events;recruit;Registries;Research;Research Personnel;response;risk stratification;Sampling;Severities;sex;Smoker;Smoking;smoking prevalence;Smoking Prevention;Spirometry;Stimulus;Structure of parenchyma of lung;System;targeted treatment;therapy development;Tobacco smoke;tobacco smoke exposure;Trans-Omics for Precision Medicine;United States National Institutes of Health;Usual Interstitial Pneumonia;Work;X-Ray Computed Tomography;Youth

PROJECT_TITLE: Clinical Biorepository Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Infectious Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Effective treatments to prevent and treat atopic dermatitis (AD) skin disease are lacking due in part to an incomplete understanding of the disease. Since the human pathogen Staphylococcus aureus has been linked to AD pathogenesis, this study will elucidate the importance of S. aureus Agr virulence and skin factors for triggering skin inflammation in AD. Therefore, the proposed work will define the role of S. aureus Agr virulence factors involved in AD pathogenesis, with the long-term goal of developing new therapies to treat AD.

PI_NAMEs: MATSUMOTO, MASANORI  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adult;Advisory Committees;Affect;Animal Model;Applications Grants;Atopic Dermatitis;Basic Science;career;career development;Cellular biology;Child;Chronic;chronic inflammatory skin;Clinical;Collaborations;cytokine;cytotoxic;Developed Countries;Development;Disease;Educational workshop;effective therapy;Epidermis;experience;Flare;Foundations;Gene Expression;Genes;genetic manipulation;Genome;Goals;human pathogen;IL17 gene;Immunologist;Inflammation;Inflammatory;insight;Interleukin-1 alpha;Interleukin-13;Interleukin-4;keratinocyte;Knowledge;Laboratories;Left;Link;Manuscripts;Mediating;meetings;Mentors;Mentorship;Metabolism;Michigan;Modeling;mouse model;novel;novel strategies;novel therapeutics;pathogen;Pathogenesis;Patients;Peptides;Phenols;Play;Preparation;prevent;Production;programs;quorum sensing;Relapse;Research;Research Activity;Research Personnel;Role;skill acquisition;skills;Skin;skin disorder;Solid;Staphylococcus aureus;Staphylococcus aureus infection;System;T-Lymphocyte;Testing;Training;Training Activity;translational scientist;TSLP gene;Type II Epithelial Receptor Cell;Universities;Up-Regulation;Virulence;Virulence Factors;virulence gene;Vitamin D Analog;Work

PROJECT_TITLE: Understanding the role of S. aureus agr virulence in atopic dermatitis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of the UCSF-Proctor Clinician Vision Scholars program is to provide a talented and diverse group of ophthalmologist Scholars with the structured mentorship, education, and career development training needed to develop into the next generation of clinician-scientists and academic leaders dedicated to improve our understanding and treatment of blinding eye diseases. !

PI_NAMEs: LIETMAN, THOMAS M;OU, YVONNE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Advisory Committees;Appointment;Biomedical Engineering;Blindness;career;career development;Career Mobility;Clinical Sciences;Collaborations;Communication;Development;didactic education;Epidemiology;Faculty;Funding;Genetic;global health;Grant;Health;Health Sciences;Human;improved;Injury;innovation;Institution;Investigation;Leadership;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Monitor;Natural regeneration;Nerve Degeneration;Ophthalmology;Oral;Outcome;Program Evaluation;programs;randomized, clinical trials;Records;Reproducibility;Research;research and development;Research Personnel;responsible research conduct;Science;Scientist;skills;Strategic Planning;Structure;success;Talents;Therapeutic;Time;Training;Translational Research;Vision;vision science;Visual System;Work;Writing

PROJECT_TITLE: UCSF-Proctor Clinician Vision Scholars K12 Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE The proposed work seeks to quantify surgeon performance and build automated assessments grounded in patient-centered outcomes to inform training surgeon on how they can improve. The nerve-sparing (NS) step during robot-assisted radical prostatectomy (RARP) is an ideal test case as it is a commonly performed procedure with significant surgeon technical variation and differences in erectile function outcomes. The knowledge gained from this research will advance other surgeries by improving the methodology of assessing surgical skill in general, objectively evaluating surgeon performance through machine learning, and developing targeted training to improve specific post-surgical outcomes.

PI_NAMEs: HU, JIM ;HUNG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Assessment tool;automated assessment;Automobile Driving;Classification;Computer Vision Systems;Consensus;Data;deep learning;Development;Dissection;E-learning;Electrocoagulation;empowerment;Evaluation;experience;Feedback;Future;Gestures;Human;improved;improved outcome;Injury;instrument;Interobserver Variability;Knowledge;Link;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Measurable;men;Methodology;Modeling;Nerve-Sparing Surgery;neurovascular;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Performance;postoperative recovery;preference;preservation;Procedures;Process;programs;Prostatectomy;quality assurance;Questionnaires;Radical Prostatectomy;Recovery;Recovery of Function;Reproducibility;Research;robot assistance;Robotics;simulation;skills;spared nerve;Statistical Models;Surgeon;surgery outcome;Surgical sutures;System;Technical Expertise;Techniques;Technology;Testing;Tissues;tool;Training;Translating;Treatment Factor;Validation;Variant;virtual reality;virtual reality simulation;Visual Pattern Recognition;Work

PROJECT_TITLE: Preserving Erectile Function by Quantifying the Nerve-Sparing step of the Robotic Prostatectomy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Human Genome;Lung;Prevention;Pulmonary Fibrosis;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: HERSH, CRAIG P (contact)

PROJECT_TERMS: Address;Affect;airway epithelium;Airway Fibrosis;Alveolar Macrophages;biobank;Biological Assay;Bleomycin;Bronchoscopy;Cell Death;cell type;Cells;Chitinase;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cigarette Smoker;Clinical;clinical heterogeneity;Collaborations;Complement;Data;Disease;disease heterogeneity;Double-Stranded RNA;Epithelial Cells;Exposure to;exposure to cigarette smoke;Fibrosis;Gene Chips;Gene Expression;Gene Expression Profiling;Genes;Genetic Variation;genome wide association study;Heterogeneity;Human;idiopathic pulmonary fibrosis;In Vitro;in vivo;large scale data;Lung;Macrophage;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;novel;Organ;Pathway interactions;Phenotype;Poly I-C;programs;Pulmonary Emphysema;Pulmonary Fibrosis;repaired;Reporting;Reproducibility;Research;respiratory;response;Sampling;single cell sequencing;single-cell RNA sequencing;Smoker;Smoking Status;Standardization;Structure of parenchyma of lung;Testing;Transcript;transcriptome;transcriptome sequencing;Viral;Work

PROJECT_TITLE: Molecular Characterization Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE T cell–mediated autoimmune diseases such as type I diabetes result from the breakdown of tolerance mechanisms in self-reactive CD8 T cells; however, we know little about how autoimmune T cell responses are initiated and sustained. Our goal is to generate a deep mechanistic understanding of the lymph node niche- dependent factors regulating CD8 T cell differentiation over the course of type I diabetes in mice and humans and to target key molecular pathways in autoimmune T cell differentiation for the prevention and treatment of type I diabetes and other autoimmune diseases.

PI_NAMEs: SCHIETINGER, ANDREA  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: adult stem cell;Antigen-Presenting Cells;Autoimmune;Autoimmune Diseases;Bar Codes;Beta Cell;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cells;cellular targeting;chemokine;chronic infection;clinical translation;clinically relevant;Complex;diabetes pathogenesis;diabetic;diabetogenic;DNA;Equilibrium;experimental study;Gene Expression Profile;Genes;Goals;Homing;Human;human disease;Image;immune cell infiltrate;immunological synapse;Inbred NOD Mice;Individual;Infiltration;innovation;innovative technologies;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Knowledge;lymph nodes;Maintenance;Malignant Neoplasms;Mediating;Methods;migration;Modeling;Molecular;Molecular Target;mouse model;multiplexed imaging;Mus;Myeloid Cells;Nature;Non obese;novel;Organ Donor;Pancreas;Pathway interactions;Patients;Pattern;peripheral blood;Population;population based;prevent;Prevention;Prevention strategy;progenitor;programs;receptor;Risk;Role;self renewing cell;self-renewal;Signal Transduction;single-cell RNA sequencing;Site;stem;stemness;Stromal Cells;T cell differentiation;T cell receptor repertoire sequencing;T cell response;T cell transcription factor 1;T-Lymphocyte;Testing;Therapeutic Intervention;transcription factor;WNT Signaling Pathway

PROJECT_TITLE: Autoimmune Stem-like CD8 T cells in Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Lung;Prevention;Pulmonary Fibrosis;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CHOI, AUGUSTINE M (contact)

PROJECT_TERMS: Bleomycin;cell injury;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;Cigarette smoke-induced emphysema;cigarette smoke-induced lung disease;cigarette smoke-induced lung injury;Cigarette Smoker;clinical phenotype;Complex;Data;Development;Disease Marker;Distal;Epithelial Cells;exposure to cigarette smoke;Fatty-acid synthase;Fibrosis;Functional disorder;Generations;Genetic;heteroplasmy;human disease;In Vitro;in vivo;indium-bleomycin;Injury;Kidney;Link;lipid metabolism;Lung Diseases;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Necrosis;Organ;Organelles;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphotransferases;PINK1 gene;Plasma;Play;Pre-Clinical Model;Process;Protein Kinase Interaction;Publishing;Pulmonary Emphysema;Pulmonary Fibrosis;Receptor Activation;Receptor-Interacting Protein;Regulation;response;Role;Severities;Severity of illness;Signal Transduction;Stimulus;Tissues;urinary;Urine

PROJECT_TITLE: Mitochondrial Dysfunction and Metabolic Regulation of the Necroptosis Pathway in COPD and IPF


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance Mitochondrial transport and mitophagy are crucial to neuornal survival and have been implicated many neurodegenerative diseases such as Parkinson's disease, Alzheimer' disease, and Amyotrophic lateral sclerosis. These diseases afflict millions of people worldwide with tremendous global economic and societal burdens. This proposal will elucidate the mechanisms underlying neurodegeneration, and is therefore relevant to public health and the mission of the NIH, as it will provide novel targets for therapuetic intervention.

PI_NAMEs: WANG, XINNAN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Binding;Biological;Calcium;Cells;Cellular biology;Complex;Data;Defect;Disease;Drosophila genus;Economics;Environment;Eukaryotic Cell;experimental study;Genetic;Glucose;Health;Homeostasis;Hypoxia;In Vitro;in vivo;Inner mitochondrial membrane;Intervention;Kinesin;Limb structure;Link;Maps;Membrane;Mission;Mitochondria;mitochondrial membrane;Motility;Movement;multicatalytic endopeptidase complex;Nature;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neurons;novel;Nutrient availability;Parkin;Parkinson Disease;Pathway interactions;Peripheral Nervous System Diseases;Persons;Phosphorylation;PINK1 gene;protein complex;Proteins;Public Health;response;Role;Signal Transduction;Stimulus;Stress;tool;Ubiquitination;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: A control center for mitochondrial navigation in neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Chronic ischemic cerebral small vessel disease (CSVD) affecting predominantly white matter (WM) in the brain is a clinically important cause of vascular cognitive impairment (VCI) and dementia. Taking advantage of a novel transgenic mouse model of CSVD/VCI, we will use a combination of transcriptomic, pharmacologic and genetic approaches to explore the role of neuroimmune signaling in WM in the initiation and progression of this disorder. Our outcome parameters will include state-of-the-art neuroimaging modalities such as multiparametric MRI and 2-photon imaging to longitudinally track WM injury and positron emission tomography (PET) with a novel microglia-targeted radioligand to assess for potential as a scalable biomarker.

PI_NAMEs: WEINSTEIN, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Affect;Age;antagonist;Astrocytes;Attenuated;attenuation;Axon;Biological Markers;Brain;Brain imaging;Cell Lineage;Cell Separation;cell type;Cells;Cerebral Ischemia;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Cholesterol;Chronic;Clinical;clinically relevant;Cognitive;Cognitive deficits;cognitive testing;Collaborations;Complement;Complex;Corpus Callosum;critical period;Data;Data Set;Dementia;Diagnostic;Diet;Diffuse;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Elements;Endothelial Cells;Exhibits;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;glial activation;Goals;gray matter;Human;Image;imaging study;Immune;Impaired cognition;Impairment;improved;in vivo;Infiltration;Inflammation;Injury;Ischemia;Ischemic Brain Injury;knock-down;Knowledge;Laboratories;Laser Speckle Imaging;Learning;Leukoencephalopathy;longitudinal positron emission tomography;LoxP-flanked allele;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Magnetic Resonance Imaging;Mediator;Memory;Microglia;Modality;Modeling;Molecular Target;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Nature;neurobehavioral;Neurocognition;neuroimaging;Neuroimmune;neuroinflammation;Neurologic;neurovascular;new therapeutic target;novel;novel marker;Oligodendroglia;optical imaging;Outcome;Outcome Assessment;overexpression;Pathogenesis;Pathologic;Pathology;Pattern;Peripheral;pharmacologic;Pharmacotherapy;Phenotype;Population;Positron-Emission Tomography;prevent;Process;radioligand;Radiology Specialty;radiotracer;Receptor Signaling;Recovery;response;Rest;Rodent;Rodent Model;Role;scale up;sensory stimulus;Series;Signal Transduction;single-cell RNA sequencing;Tamoxifen;TGFB1 gene;Therapeutic;Therapeutic Intervention;Time;Tissues;tractography;transcriptome;transcriptomics;Transforming Growth Factors;Transgenic Mice;two-photon;Universities;uptake;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Dementia;white matter;white matter injury

PROJECT_TITLE: Role of Microglia in Cerebral Small Vessel Disease (CSVD)/Vascular Cognitive Impairment (VCI)


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: SAN JUAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE Specific genetic disorders that cause craniofacial birth defects have been shown to be caused by mutations in the TWIST1 and TWIST2 genes, which contain the information for DNA-binding proteins that regulate target genes. The molecular mechanisms for the dysfunction of these mutant TWIST2 proteins are not well understood. This project will contribute to the understanding of how the DNA binding properties are affected in TWIST1/2 mutant proteins and help in the identification of gene targets of these transcription factors, the cellular pathways in which they participate and their role in development.

PI_NAMEs: CADILLA, CARMEN LYDIA (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Affect;Affinity;ATAC-seq;autosome;Barbering;BHLH Protein;Binding;Binding Sites;Bioinformatics;Biological Assay;Cell Communication;Cell Polarity;Cells;Chromatin Structure;Circular Dichroism;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;Craniosynostosis;Development;Dimerization;Disease;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;DNA sequencing;DNA-Binding Proteins;Dominant-Negative Mutation;Electrophoretic Mobility Shift Assay;Embryonic Development;EMSA;Event;experimental study;Face;Family;Functional disorder;gain of function;Gene Expression;Gene Mutation;Gene Targeting;Genes;Genetic Diseases;Genetic Variation;Genome;Genomics;Glutamates;Goals;Head;Helix-Turn-Helix Motifs;histone modification;Human Development;In Vitro;in vivo;Interferometry;Macrostomia;member;method development;Methods;Missense Mutation;Molecular;mutant;Mutation;Nucleotides;Outcome;Pathogenicity;Pathway interactions;Patients;Property;protein complex;protein function;protein purification;Proteins;Publishing;Rare Diseases;Role;Setleis syndrome;Shapes;Signaling Molecule;Specificity;Structure;Syndrome;three dimensional structure;transcription factor;TWIST1 gene;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of TWIST bHLH Transcription Factors Binding to Functional Target Regions


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Ascending thoracic aortic aneurysm (ATAA) is a major cardiovascular health problem characterized by a dilated aorta that may eventually dissect or rupture (fail). An accurate assessment of ATAA failure risk is a major clinical need. This project will use experimental biomechanics, computer modeling, and real and virtual patient imaging data to better assess ATAA failure risk.

PI_NAMEs: BAROCAS, VICTOR H;WAGENSEIL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Age;Aneurysm;Animal Model;Aorta;Autopsy;Biological Markers;biomarker identification;Biomechanics;Biophysics;Blood flow;Cadaver;cardiovascular health;Categories;Cessation of life;Clinical;Computer Models;Computer Systems;cost;Coupled;Dangerousness;Data;Diameter;Disease Outcome;Dissection;Equilibrium;Event;experience;Experimental Models;experimental study;Failure;falls;Genetic;Geometry;Growth;Guidelines;hemodynamics;Human;human data;human tissue;Image;Individual;Intervention;Liquid substance;Literature;Longitudinal Studies;Machine Learning;Marfan Syndrome;mechanical properties;Mechanics;Modeling;models and simulation;Monitor;mouse model;Mus;novel;Operative Surgical Procedures;Outcome;outcome prediction;Patient imaging;Patient-Focused Outcomes;Patients;Physics;Principal Component Analysis;public health relevance;Publishing;repaired;Reproducibility;Risk;Rupture;Scanning;Shapes;simulation;Solid;Stress;surgical risk;System;Testing;Thoracic Aortic Aneurysm;Time;Tissue Model;Tissues;tool;Training;virtual;virtual human;virtual patient;virtual reality simulation;Work

PROJECT_TITLE: Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysm

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: ELIAS, JACK A (contact)

PROJECT_TERMS: Address;Animal Model;Apoptosis;Binding;Biogenesis;Biology;Bleomycin;Cell Death;CHI3L1 gene;Chitinase;Chronic Obstructive Pulmonary Disease;Cigarette smoke-induced emphysema;Cigarette Smoker;Clinical;Complex;Cyclin-Dependent Kinases;Deposition;differential expression;Disease;Epigenetic Process;Epithelial Cells;Evaluation;exposure to cigarette smoke;Fatty-acid synthase;Fibrosis;Fostering;Galectin 3;Generations;Genes;Genetic;glycosylation;Haplotypes;helicase;idiopathic pulmonary fibrosis;in silico;In Vitro;Inbreeding;Injury;injury and repair;innate immune pathways;interstitial;Lung;Mediating;Mediator;Metabolism;Microarray Analysis;Mitochondria;Modeling;Modification;mouse model;Mus;Outcome;overexpression;Pathogenesis;Pathology;Pathway interactions;patient subsets;Patients;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PINK1 gene;Play;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;prototype;Pulmonary Emphysema;Pulmonary Fibrosis;receptor;receptor binding;Regulation;repaired;Research Personnel;response;Role;Sampling;Site;Structure;Thinking;tissue injury;Tissues;trafficking;Transgenic Mice

PROJECT_TITLE: Differential Roles of Chi3l1 and its receptors in COPD and IPF


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Approximately 15 million people in the United States are at risk for developing cirrhosis, liver failure, hepatocellular carcinoma and death due to non-alcoholic steatohepatitis (NASH), while there are less than 10,000 liver transplants performed annually in the United States. We are developing a novel stem cell and bioengineering-based platform where we will investigate two key factors in NASH, the effects of matrix stiffness and cell stress from unfolded proteins on induced pluripotent stem cell-hepatocytes (iPSC-hepatocytes). We will then make iPSC-hepatocytes from NASH patients listed for liver transplantation and controls to help develop platforms to study the causes of severe, progressive NASH and enable the development of biomarkers for NASH.

PI_NAMEs: GREEN, RICHARD M;PURDY, JOHN GERARD;WERTHEIM, JASON A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Agonist;American;Animal Model;Animals;bile acid metabolism;Bile Acids;Bioinformatics;Biological Markers;Biology;biomarker development;Biomedical Engineering;Cell Differentiation process;cell growth;Cell Line;Cell Transplantation;cell type;Cells;Cellular Metabolic Process;Cellular Stress;Cessation of life;Characteristics;Chemicals;Cirrhosis;Clinical;Collaborations;cost;Development;Diabetes Mellitus;Diet;Disease Progression;disorder control;disorder risk;drug development;Drug Screening;endoplasmic reticulum stress;Environment;Environmental Risk Factor;Evaluation;experience;Experimental Designs;Extracellular Matrix;Fatty Acids;Fibrosis;Functional disorder;Gel;Gene Expression;genetic risk factor;Growth;Hepatic;Hepatocyte;Hepatology;high throughput technology;high-throughput drug screening;Human;human model;in vivo;Individual;induced pluripotent stem cell;Institution;Insulin Resistance;Investigation;lipid metabolism;lipidomics;Lipids;Liver;liver biopsy;Liver diseases;Liver Failure;Liver Fibrosis;Liver Function Tests;liver injury;liver stiffness;liver transplantation;Measures;Metabolic;Metabolic Pathway;Metabolic stress;Metabolic syndrome;metabolomics;minimally invasive;Molecular Chaperones;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;post-transplant;precision drugs;Primary carcinoma of the liver cells;Proteins;Recurrence;Recurrent disease;Reducing Agents;resistance factors;response;Risk;Severity of illness;Signal Transduction;stem cell biology;stem cells;stress reduction;System;tauroursodeoxycholic acid;Technology;Testing;tool;trait;Transplantation Surgery;United States;Virulence Factors

PROJECT_TITLE: Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Adult stem cells exist in a dynamic microenvironment termed the niche, which provides signals for stem cell maintenance and self-renewal. In the Drosophila testis, I have observed a novel phenotype, niche cell hypertrophy, upon knockdown of an endocytic tumor suppressor gene. A further understanding of this crosstalk between stem cells and their niches is crucial for understanding processes such as gametogenesis, cancer, development, and regeneration.

PI_NAMEs: GRACE, MARA RUTH (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Ablation;adult stem cell;Affect;Aging;Back;Cell Count;cell growth;Cell Lineage;Cell Maintenance;Cell Size;Cells;Cellular Morphology;Communication;Complement;Complex;Confocal Microscopy;Core Facility;Cyst;Data;Data Set;Daughter;Development;Developmental Process;Drosophila genus;Drosophila melanogaster;Educational process of instructing;Educational workshop;Electron Microscopy;Endocytosis;Ensure;Equilibrium;experience;experimental study;Flow Cytometry;Fluorescence;fly;follow-up;Foundations;gain of function;Gametogenesis;Gene Expression;Genes;Genetic;Genomics;Germ Cells;Grant;Growth;Homeostasis;Hypertrophy;Immune Sera;Injury;insight;Intestines;knock-down;life span;loss of function;Maintenance;Malignant Neoplasms;Manuscripts;Measurement;Mediating;medical schools;member;Mentors;Mesenchymal;Microscopy;model organism;Morphology;mosaic analysis;mutant;Natural regeneration;novel;Oncology;Organism;Pathway Analysis;Pathway interactions;Phenotype;Ploidies;Polyploidy;Process;receptor;Regenerative Medicine;Reproduction;Research;Research Training;Resources;RNA Interference;Role;self-renewal;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Spermatogenesis;stem cell biology;stem cell niche;stem cell population;stem cells;Surveys;symposium;System;teaching assistant;Testing;Testis;tissue regeneration;tissue repair;Tissues;tool;transcriptomics;transdifferentiation;Transgenic Organisms;Tumor Suppressor Genes;tumorigenesis;undergraduate student;Work;Writing

PROJECT_TITLE: The role of ESCRTs in signaling within the testis stem cell niche

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The obligate intracellular bacterial pathogen Coxiella burnetii is the causative agent of human Q fever. We propose to elucidate the molecular mechanisms behind Coxiella’s ability to survive in the acidic intracellular niche, the Coxiella Containing Vacuole (CCV). Understanding how C. burnetii initiates replication under acid stress and actively regulates CCV pH to maintain viability is critical to identify new therapeutic targets.

PI_NAMEs: GILK, STACEY D (contact);OMSLAND, ANDERS

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: acid stress;Acute;Animals;Antibiotic Therapy;Antibiotics;Bacteria;Biogenesis;Biological;biological adaptation to stress;Carbon Dioxide;carbonate dehydratase;Catabolism;Cells;Characteristics;Chronic;Chronic Disease;chronic infection;Clinical;Coxiella;Coxiella burnetii;Cytoplasm;Data;Desiccation;Digestion;Disease;Disease Outbreaks;Endocarditis;Enzymes;Epidemiology;Exposure to;Fatigue;flu;gene network;Growth;Homeostasis;Human;human pathogen;Immune response;Individual;Infection;intracellular parasitism;Knowledge;Life;Lysosomes;Maintenance;Metabolic;Metabolism;Modeling;Molecular;Netherlands;new therapeutic target;novel;novel therapeutics;Nutrient;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patient Noncompliance;Patients;Peptide Hydrolases;pH Homeostasis;Phagocytes;Phagolysosome;Phosphoric Monoester Hydrolases;Proteins;Q Fever;Regimen;Regulation;Replication Initiation;Reproduction spores;response;Role;Stress;Testing;therapeutic target;transcription factor;Transcriptional Activation;Vacuole;Variant;Virulence;Zoonoses

PROJECT_TITLE: Coxiella survival mechanisms in the intracellular niche

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Human Genome;Lung;Precision Medicine;Pulmonary Fibrosis;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: SILVERMAN, EDWIN K (contact)

PROJECT_TERMS: Address;biobank;Biological;Blood;Blood specimen;Cell Death;Cells;Characteristics;chest computed tomography;Chitinase;Chronic Obstructive Pulmonary Disease;Cigarette Smoker;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Data;Development;disorder subtype;DNA Methylation;Environmental Risk Factor;Epigenetic Process;Epithelial Cells;Fibroblasts;Fibrosis;gene interaction;gene regulatory network;Genetic;genetic variant;genome sequencing;Haplogroup;Heterogeneity;Human;idiopathic pulmonary fibrosis;Individual;Inflammation;knockout gene;Link;Lung;Macrophage;Measures;Mitochondria;Molecular;monocyte;Mus;National Heart, Lung, and Blood Institute;Network-based;Participant;Pathway Analysis;Pathway interactions;Phenotype;Plasma;Population;population based;Predisposition;Process;programs;protein protein interaction;Proteins;Proteomics;Pulmonary Emphysema;Research;Resources;Sampling;Smoker;Structure of parenchyma of lung;study population;Susceptibility Gene;System;Systems Analysis;Testing;Trans-Omics for Precision Medicine;transcriptome sequencing;Untranslated RNA;Validation;Variant;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Integrating Omics, Networks, and Functional Studies in COPD and IPF


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE Macrophages are increasingly used to transport nanoparticles to inflamed tissues for medical imaging and drug delivery. However, the effect of combining nanoparticles on macrophage phenotypes is poorly understood. The goal of this MIRA is to create a set of design rules that will allow researchers to select nanoparticle designs that give rise to specific cellular phenotypes and transport behaviors.

PI_NAMEs: SHIELDS IV, CHARLES WYATT (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Area;Autoimmune Diseases;Behavior;Cardiovascular Diseases;Cell surface;Cells;chemokine receptor;Clinical;Communicable Diseases;Complex;Contrast Media;design;differential expression;Disease;Drug Delivery Systems;epigenomics;Genes;Goals;Immune;improved;Infiltration;Inflammation;Inflammatory;Knowledge;Laboratories;Macrophage;Malignant Neoplasms;Measures;Mediating;Medical Imaging;Modeling;molecular phenotype;Mus;nanofabrication;nanoparticle;nanoparticle delivery;next generation;Outcome;Pharmaceutical Preparations;Phenotype;physical property;recruit;Research Personnel;response;Role;Shapes;Site;Specificity;Tissues;tool;transcriptomics;Vaccines;Work

PROJECT_TITLE: Adoptive Macrophage Transfers for Nanoparticle Delivery


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Cancer is the leading cause of death among Latinos in the US, who now represent the largest minority group. Latino cancer patients engage in advance care planning less often and receive less value-consistent care at the end-of-life more often than non-Latino cancer patients. The proposed research addresses the pressing need to reduce Latino EoL care disparities by developing an intervention for improving the therapeutic alliance between oncologists and their Latino cancer patients.

PI_NAMEs: TERGAS, ANA ISABEL (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: acceptability and feasibility;Address;Advance Care Planning;Advanced Malignant Neoplasm;Applications Grants;Award;behavior change;Behavior Therapy;Belief;cancer care;Cancer Patient;care outcomes;career;Caring;Cause of Death;Client satisfaction;clinical practice;Collaborations;Communication;Competence;Data;Data Analyses;Development;Disparity;disparity reduction;effective intervention;efficacy evaluation;Emotional;Empathy;end of life;end of life care;end of life outcomes;Ethnic Origin;evidence base;expectation;experience;Family Caregiver;Feedback;field study;Focus Groups;Foundations;Funding;Future;Goals;Grant;hospice utilization;Hospitals;Human;Immigrant;Impairment;implementation science;improved;Intervention;intervention refinement;Interview;Latino;Latino Population;Literature;Malignant Neoplasms;Measures;Medical;Mentorship;Methods;Minority Groups;Modeling;Observational Study;Oncologist;Participant;patient engagement;patient oriented;Patients;Perception;Physicians;pilot test;Prediction of Response to Therapy;preference;primary outcome;prognostic;programs;prospective;Provider;Psychotherapy;Quality of life;Randomized;Religion;Reporting;Research;Resuscitation;secondary outcome;Self Determination;Services;shared decision making;Site;Terminal Disease;Theoretical model;theories;Therapeutic;therapy design;therapy development;Training;treatment as usual;Treatment Effectiveness;Treatment Efficacy;Trust;United States National Institutes of Health

PROJECT_TITLE: Impact of the Therapeutic Alliance on Reduction of Disparities in Latino End-of-Life Cancer Care

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The process by which stem cells differentiate into parietal cells in the stomach lining is poorly understood, yet it underlies a variety of human health conditions, including Helicobacter pylori infection, peptic ulcers, gastroesophageal reflux disease, autoimmune gastritis, chronic atrophic gastritis, pyloric metaplasia, and gastric cancers. We aim to characterize the molecular and cellular steps involved in this differentiation process, define how ERRγ and other factors are critical for healthy parietal cell function, and establish utility for those factors in therapeutic approaches that could be developed for the treatment of conditions related to abnormal parietal cell abundance and activity.

PI_NAMEs: MILLS, JASON C (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Ablation;Acids;adenylate kinase;Affect;Agonist;antagonist;ATP phosphohydrolase;Atrophic;Atrophic Gastritis;autoimmune gastritis;Bacteria;base;Breeding;cancer risk;CD36 gene;Cell Death;Cell Differentiation process;Cell Lineage;Cell Physiology;cell regeneration;cell type;Cells;cellular transduction;Censuses;Chief Cell;ChIP-seq;chronic infection;Co-Immunoprecipitations;Data;diphtheria toxin receptor;Disease;Electron Microscopy;Electrons;Embryo;Enterobacteria phage P1 Cre recombinase;Enzymes;Epithelial Cells;Epithelium;estrogen-related receptor;experimental study;Functional disorder;Funding;gastric corpus;Gastric Metaplasia;Gastric Parietal Cells;Gastroesophageal reflux disease;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth Factor;Health;Helicobacter Infections;Helicobacter pylori;Homeostasis;Hormones;Human;IL17 gene;inducible Cre;Inflammation;Injury;Interferon Type II;Learning;LoxP-flanked allele;malignant stomach neoplasm;Mass Spectrum Analysis;Metaplasia;Metformin;Microscopic;Modeling;Molecular;mouse development;mouse model;Mus;Natural regeneration;Neck;New Agents;novel;novel therapeutic intervention;Nuclear;Organoids;Parietal;Pathway interactions;Patients;Peptic Ulcer;Pharmaceutical Preparations;postnatal;Process;progenitor;programs;Proliferating;Proteins;Pump;Regulation;Reporter;Series;Signal Transduction;Sorting;spasmolytic polypeptide;Specific qualifier value;stem cell biomarkers;stem cell differentiation;stem cells;Stomach;Testing;Therapeutic;Time;tool;Transcription Coactivator;transcription factor;transcriptome sequencing;translational applications;Transmission Electron Microscopy;Work

PROJECT_TITLE: REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Proposed studies will identify novel genetic loci that determine stroke vulnerability in mice. In view of the conserved genome structures and physiologies of mice and humans, this will ultimately contribute to the discovery of genes and gene networks that impact the human disease. More complete understanding of genetic factors contributing to variation in stroke severity, expected to result from this study, should help guide future prevention and therapeutic approaches.

PI_NAMEs: MULLIGAN, MEGAN KATHLEEN;NOWAK, THADDEUS S. (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Affect;Automobile Driving;Bioinformatics;biomarker panel;C57BL/6 Mouse;causal variant;Chromium;cohort;coisogenic;comparative;Comparative Genomic Analysis;Confidence Intervals;CRISPR/Cas technology;Data;design;Detection;Dominant Genetic Conditions;dominant genetic mutation;Exhibits;Experimental Models;Future;gene discovery;gene network;General Population;Genes;Genetic;Genetic Determinism;genetic variant;Genome;genome editing;genome sequencing;genome-wide;genomic locus;Genomics;Genotype;Heritability;Human;human disease;Individual;Infarction;Inherited;Intervention;Ischemia;Link;Maps;Mediating;Methodology;Molecular Biology Techniques;Mouse Strains;Mus;novel;Parents;Phenotype;Physiology;Population;Prevention;Quantitative Trait Loci;repaired;Resources;segregation;Severities;sex;Source;Stroke;stroke risk;Structure;Technology;Testing;Therapeutic;tool;translational potential;United States National Institutes of Health;Validation;Variant;whole genome

PROJECT_TITLE: Genetics of stroke vulnerability in C57BL/6 mouse substrains

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: BAYIR, HÜLYA  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Accidents;Acute;anakinra;Antibodies;Antigens;Apoptosis;apoptosis inducing factor;Apoptotic;Bacteria;Blood;bone marrow hyperplasia;CASP1 gene;Cell Death;Cell membrane;Cell Membrane Permeability;Cell Nucleus;Cessation of life;Chemotactic Factors;clinical translation;Computer Models;cytokine;Data;design;Development;Disease;Dose;Effectiveness;effectiveness evaluation;Epithelial Cells;Event;Exposure to;Free Radicals;Funding;gastrointestinal epithelium;Generations;Goals;IL18 gene;improved;In Vitro;in vivo Model;Infection;Inflammasome;Inflammatory;Inflammatory Response;inhibitor;interest;Interleukin-1 beta;Interleukin-1 Receptors;Intestines;Ionizing radiation;irradiation;Knowledge;Link;lipid biosynthesis;lipid mediator;lipidomics;Lipids;Mediating;Medical;Mitochondria;Mitochondrial Proteins;Molecular;Necrosis;novel;novel therapeutics;Nuclear;Nuclear Translocation;Nuclear Warfare;Outer Mitochondrial Membrane;oxidation;Oxidation-Reduction;Participant;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phospholipids;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Production;programs;Proteins;Radiation;Radiation exposure;Radiation Injuries;radiation mitigation;radiation mitigator;Radioactive;radiological attack;Radiology Specialty;Reactive Oxygen Species;Recovery;response;Role;Signal Pathway;Signal Transduction;small molecule inhibitor;Stream;Stress;Structure-Activity Relationship;Syndrome;Testing;Therapeutic;Tissues;trafficking;Water;Whole-Body Irradiation

PROJECT_TITLE: Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: OVERALL PROJECT NARRATIVE  Age is the most important risk factor for developing Alzheimer’s disease and related dementias, but the mechanisms and development of successful treatments remain elusive. We propose to determine how age- related changes in both neurons and non-neuronal brain cells can drive these pathologies, with the long term goal of using these insights into effective interventions.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Applications Grants;Astrocytes;Automobile Driving;Bioinformatics;Brain;brain cell;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Death;cell type;Cells;Clinical;Collaborations;cost;Data;Dementia;Development;Disease;Disease Progression;Economics;effective intervention;effective therapy;Emotional;Endothelial Cells;Etiology;Family;Goals;Head;Human;induced pluripotent stem cell;Inflammation;insight;interest;Intervention;Knowledge;Macrophage;member;Metabolic;Metabolism;metabolome;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel strategies;Oligodendroglia;Organoids;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Population;Productivity;Program Research Project Grants;programs;Proteome;Proteomics;Publishing;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;senescence;senescent cell;senolytics;social;Testing;Time;transcriptomics;Translating

PROJECT_TITLE: Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: age related;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Bioinformatics;Brain;Budgets;career development;Cell Aging;Cells;Collaborations;Communication;Communities;Computer software;Consultations;Data;Data Analyses;data management;Databases;Dedications;Dementia;design;Emotional;Ensure;Equipment;Evaluation;experimental study;Faculty;Financial Hardship;Fostering;Funding;Goals;Grant;Human Resources;Institution;Joints;large datasets;Manuscripts;meetings;member;metabolomics;multiple omics;National Institute on Aging;Participant;Postdoctoral Fellow;Principal Investigator;program dissemination;Program Research Project Grants;Progress Reports;Proteomics;Published Comment;Reproducibility;Research Personnel;Resolution;Science;Services;Students;success;symposium;Training;transcriptome sequencing;Travel;United States;United States National Institutes of Health;Visit;web site

PROJECT_TITLE: Administration and statistical/bioinformatics core


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative  Monoamine neurotransmitters such as dopamine, norepinephrine, and serotonin play essential roles in the nervous system by fine tuning learning and behavior, and malfunction of monoamine neurotransmission has been implicated in numerous neuropsychiatric diseases (depression, anxiety, substance use, and Parkinson’s disease). We will develop new imaging probes and methods to enable detailed readouts of neurotransmission processes on a synaptic level and advance neurobiology and neuropharmacology.

PI_NAMEs: SAMES, DALIBOR  (contact);SULZER, DAVID

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Address;Adrenergic Receptor;Amphetamines;Animals;Anxiety;Attention;Attention deficit hyperactivity disorder;Axon;Behavior;Behavioral;Biological Assay;Brain;brain control;brain tissue;Catecholamines;Cell Culture Techniques;Cells;Central Nervous System;Cerebellum;Chemistry;Cognition;combinatorial;Complex;Corpus striatum structure;design;Development;Diffusion;Dopamine;Dopamine Receptor;Drug Addiction;Drug Modulation;ecstasy;Environment;Excitatory Synapse;extracellular;Fiber;Fluorescence;Fright;Glutamates;Hippocampus;Image;imaging capabilities;Imaging Device;imaging modality;imaging probe;in vivo;Individual;Inhibitory Synapse;insight;Interdisciplinary Study;Ion Channel;Kinetics;Label;Learning;Locomotion;Measures;Membrane;Memory;Mental Depression;Methods;microscopic imaging;Molecular;Molecular Probes;Monitor;monoamine;multiphoton imaging;multiphoton microscopy;Mus;Nervous System;Nervous System Disorder;Neurobiology;Neuropharmacology;neuropsychiatric disorder;Neurosciences;neurotransmission;Neurotransmitters;noradrenergic;Norepinephrine;novel imaging technique;Optical reporter;Optics;optogenetics;Parkinson Disease;Pharmaceutical Preparations;pharmacologic;Photometry;Photons;Play;Post-Traumatic Stress Disorders;postsynaptic;presynaptic;Process;programs;Property;Proteins;psychostimulant;Psychotropic Drugs;Quinolones;receptor;Reporter;Reporting;Research Support;response;Rewards;Role;Safety;Schizophrenia;sensor;Sensory;Series;Serotonin;serotonin transporter;Signal Transduction;Site;Slice;small molecule;source localization;Stimulus;substance use;Synapses;Synaptic plasticity;Synaptic Vesicles;System;Tail;temporal measurement;tool;Tracer;transmission process;uptake;Varicosity;vesicular monoamine transporter 2;Viral

PROJECT_TITLE: Development of Fluorescent False Neurotransmitters

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Address;age related;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Astrocytes;Brain;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Line;Cell model;cell type;Cells;cellular imaging;Cerebrum;Coculture Techniques;combat;Dementia;Disease;Disease Progression;Electrophysiology (science);Ensure;Equipment;Ethics;experience;Freezing;Frontotemporal Dementia;Goals;Human;human induced pluripotent stem cells;Image;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Infrastructure;Intervention;Knowledge;Maintenance;Measurement;Microglia;Modeling;mouse model;Mus;Mycoplasma;Neurons;Onset of illness;Organizational Objectives;Organoids;Participant;Pathway interactions;Patients;Postdoctoral Fellow;programs;Quarantine;Reproducibility;Research;Research Personnel;Role;Scientist;senescent cell;Services;Source;Specificity;stem cell model;student training;tau mutation;Technology;Testing;Training;Validation

PROJECT_TITLE: ADRD Induced pluripotent stem cell/organoid core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SCHILLING, BIRGIT  (contact)

PROJECT_TERMS: Affect;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Astrocytes;Bioinformatics;Biological Assay;biological research;Biology;biomarker discovery;Biomedical Research;Brain;candidate marker;Cell Aging;Cell Culture Techniques;cell type;Cells;Cerebrum;Chromatography;Coculture Techniques;Collaborations;Communication;Data;Data Analyses;data integration;data mining;Databases;Dedications;Dementia;design;Disease;Disease Progression;exosome;experience;experimental analysis;experimental study;Exposure to;Faculty;functional decline;Goals;Individual;induced pluripotent stem cell;Infrastructure;innovation;insight;instrument;instrumentation;Intervention;mass spectrometer;Mass Spectrum Analysis;Measures;member;Metabolism;metabolome;metabolomics;Methodology;Methods;Microglia;mid-career faculty;Mission;Modeling;Modernization;Molecular;Monitor;mouse model;Multiomic Data;multiple omics;Neurons;novel;Organoids;Pathway interactions;Pharmacologic Substance;Phenotype;Post Translational Modification Analysis;Post-Translational Protein Processing;Postdoctoral Fellow;programs;Protein Analysis;protein biomarkers;Protein Chemistry;Protein Dynamics;Protein Secretion;Proteins;Proteome;Proteomics;Quality Control;Reagent;Reproducibility;Research;Research Personnel;Resolution;Resources;Sampling;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Pathway;Signal Transduction;Signaling Protein;single cell analysis;stem cell model;Students;System;tau Proteins;tau-1;Technology;Time;Tissue Sample;tool;Training;Work

PROJECT_TITLE: Proteomics/Metabolism Core


NIH_SPENDING_CATS: Neurosciences;Urologic Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE As the urinary bladder fills with urine, sensory nerves send signals to the brain to indicate its level of fullness. However, the mechanisms used to detect the level of urine in the bladder are poorly understood. Our overall goal in this project is to understand how the bladder senses fullness, as this is a key issue to understanding normal bladder function and will provide new insights into bladder pathology.

PI_NAMEs: HEPPNER, THOMAS ;HERRERA, GERALD M. (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Address;Affect;afferent nerve;Algorithms;Amaze;Attention;Basic Science;Behavior;Bladder;Bladder Dysfunction;Brain;Cations;cell type;Central Nervous System;Clinical;comparative;Conscious;Coupling;Data;Disease;Event;Fibroblasts;Future;Genetic;Giant Cells;Goals;Grant;Heart;Image;Image Analysis;Imaging Techniques;in vivo;insight;interstitial cell;intravesical;Ion Channel;Knockout Mice;Lead;Life;Liquid substance;Lower urinary tract;Measures;mechanical properties;mechanotransduction;Mediating;Methodology;Modeling;Motility;Motion;mouse model;Mus;Nerve;novel;novel imaging technique;optogenetics;Output;Overactive Bladder;Pain;Pathology;pharmacologic;Physiological;Physiological Processes;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;pressure;Process;Property;real time monitoring;Regulation;Reporter;Reporting;response;Role;Sensory;signal processing;Signal Transduction;Site;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Stretching;Surface;System;Techniques;Time;tool;Translating;Urine;Urodynamics;Urothelial Cell;Urothelium;Work

PROJECT_TITLE: How is Fullness Sensed in the Urinary Bladder?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Relevance: Automatic susceptibility based multi-atlas tool offers reliable QSM measurements. Establishing the role of iron accumulation in MCI/dementia and associated risk factors is critical in preventing this disease by early risk factor modification.

PI_NAMEs: LI, XU ;QIAO, YE  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Abeta clearance;Abeta synthesis;abeta toxicity;Acceleration;Adult;aged;Aging;aging population;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anatomy;Ancillary Study;apolipoprotein E-4;Atherosclerosis Risk in Communities;Atlases;biobank;biracial;Brain;Brain imaging;brain iron;brain magnetic resonance imaging;Brain Mapping;Brain region;brain tissue;Calibration;Clinical;Clinical Data;cofactor;cognitive function;cognitive performance;cognitive testing;cohort;Communities;Data;Dementia;demographics;Development;Disease;Elderly;Elements;Etiology;Event;extracellular;Failure;frontal lobe;Funding;Genetic;Genetic Determinism;genetic variant;genome wide association study;gray matter;Healthcare;Healthcare Systems;high risk;Hippocampus;Human;hyperphosphorylated tau;Image;Imaging Techniques;Immunotherapy;Impaired cognition;Intracranial Atherosclerotic Disease;Iron;late life;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mendelian randomization;Metabolism;Microvascular Dysfunction;middle age;mild cognitive impairment;Modification;Neurodegenerative Disorders;Neurofibrillary Tangles;older adult;Oxidative Stress;Participant;Pathogenesis;Pathologic;Pathology;Peptides;Performance;Phase;Play;Population;Population Study;Positron-Emission Tomography;pre-clinical;Predisposition;Prevalence;prevent;Production;Prospective, cohort study;Protocols documentation;reconstruction;recruit;Resolution;Risk Factors;Role;Sampling;Schedule;Senile Plaques;Signal Transduction;Source;tau Proteins;Temporal Lobe;Testing;Therapeutic;Tissues;tool;United States National Institutes of Health;Variant;vascular risk factor;Visit

PROJECT_TITLE: Contribution of Cerebral Iron Load to Cognitive Function in Older Adults with High Risk to Develop Alzheimer's Disease

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Lay Summary This project aims to use blood-based sequencing and imaging to help guide the use of immune checkpoint inhibitors for patients with non-small cell lung cancer (NSCLC). The proposed studies will develop new algorithms to apply blood-based tumor sequencing and novel radiomic image analyses to predict which patients are likely to respond to immune checkpoint inhibitors alone or with chemotherapy, and to help determine whether a patient is responding to therapy. The new compound blood-imaging biomarkers will address unmet clinical needs in thoracic oncology by helping guide therapeutic decision making without requiring invasive biopsies, ushering in a new era of non-invasive precision immunooncology.

PI_NAMEs: VOKES, NATALIE  (contact);WU, JIA

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Algorithms;analytical tool;bench to bedside;Biological;Biological Assay;Biological Markers;Biology;Biopsy;Blood;Blood specimen;blood treatment;Cancer Biology;Cancer Center;cancer genomics;Cancer Patient;checkpoint therapy;chemotherapy;Classification;Clinical;clinical assay development;Clinical Data;clinical decision-making;Clinical Management;clinical predictors;clinically relevant;Code;cohort;Collaborations;Combined Modality Therapy;Coupling;Data;data integration;data modalities;Data Science;Data Set;Databases;Decision Making;deep learning;Development;DNA Sequence Alteration;DNA sequencing;FDA approved;Foundations;General Hospitals;Goals;Image;Image Analysis;imaging biomarker;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunooncology;Immunotherapy;improved;improved outcome;individual patient;innovation;Investigation;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Massachusetts;Measurable;Methylation;Modeling;Molecular;molecular phenotype;Molecular Profiling;Multiomic Data;Mutation;Non-Small-Cell Lung Carcinoma;novel;Oncology;Organ;Outcome;outcome prediction;Patients;Performance;personalized immunotherapy;PET/CT scan;Phase;Phenotype;predicting response;predictive modeling;programmed cell death ligand 1;prospective;Provider;Radiogenomics;radiological imaging;Radiology Specialty;radiomics;Recurrent disease;Regimen;Research;response;Scanning;Selection for Treatments;Site;Specimen;Subgroup;success;Techniques;Testing;Therapeutic;Thoracic Oncology;Tissues;Toxicity due to chemotherapy;Translating;Treatment Protocols;treatment response;treatment strategy;tumor;Tumor Biology;tumor DNA;Validation

PROJECT_TITLE: Integrated blood and radiomic subtyping to guide immunotherapy treatment selection and early response assessment in metastatic non-small cell lung cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Chemokines play important roles in immune cell trafficking between and within tissues. Current immunotherapies have exposed ‘blind spots’ when it comes to understanding how effector T cells access and position themselves within inflamed tissues. The goal is to gain new knowledge of chemokine receptor requirements for CD4 T cell function in inflamed tissues that inform the design of stage-specific therapeutics for tissue entry, exploration, positioning at infection foci and eventual resolution.

PI_NAMEs: FOWELL, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Activities of Daily Living;Antigens;antimicrobial;Area;Attenuated;Bar Codes;Binding;Biological;CCR5 gene;CCR8 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;chemokine;chemokine receptor;Chemotactic Factors;chimeric antigen receptor T cells;Complex;Cues;CXC chemokine receptor 3;CXCR3 gene;cytokine;Cytokine Signaling;Data;design;Down-Regulation;effector T cell;Equilibrium;Event;fitness;Gene Expression;Genetic Transcription;Goals;Heterogeneity;Hot Spot;imaging platform;Immune;Immune system;Immunotherapy;in vivo;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;insight;Instruction;interstitial;intravital imaging;Knowledge;Ligands;Location;lymph nodes;Malignant - descriptor;Malignant Neoplasms;Measures;Microanatomy;migration;Molecular;monocyte chemoattractant protein 1 receptor;optogenetics;pathogen;Pattern;Play;Positioning Attribute;programs;protein expression;receptor expression;recruit;Regulation;Resolution;response;restraint;Retinal blind spot;Role;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;Skin;System;T-Lymphocyte;targeted treatment;Testing;Th1 Cells;Therapeutic;Time;Tissues;tool;trafficking;Transcript;transcriptome sequencing;transcriptomics;transmission process;tumor;Visualization

PROJECT_TITLE: Remodeling of Lymph Node-Derived Cytokine Responses at the Infected Tissue Site

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: MELOV, SIMON  (contact)

PROJECT_TERMS: abeta accumulation;Address;Age;age related;Aging;Alzheimer's Disease;Amyloid beta-Protein;Animal Model;Astrocytes;ATAC-seq;Automobile Driving;biological adaptation to stress;Biological Models;Brain;brain tissue;Cell Aging;Cell Enlargement;Cell model;Cell Nucleus;Cell Physiology;Cell Separation;Cell Size;cell type;Cells;Chromatin;Cognitive deficits;combat;Communication;Complex;Cryoultramicrotomy;Cultured Cells;Data;Dementia;Detection;Disease;Economics;effective therapy;Elderly;Emotional;Family;Frequencies;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Targeting;Genomics;Goals;Heterogeneity;Impairment;in vivo;Induced Neurons;insight;instrumentation;Knowledge;Libraries;Literature;Masks;meter;Methodological Studies;Methods;Microglia;Morphology;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;new technology;novel;novel strategies;Organism;paracrine;Pathway interactions;Patients;Population;prevent;Procedures;Process;programs;Property;Proteins;Refractory;Research;Risk Factors;Role;senescence;senescent cell;Series;single cell analysis;Slide;tau Proteins;Techniques;Technology;Testing;Tissues;transcriptome sequencing;transcriptomics;Validation;whole genome

PROJECT_TITLE: Single cell analysis core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project narrative RNA polymerase III (Pol III) transcribes transfer RNA (tRNA) genes essential for protein synthesis and cell growth and thus has increased activity in cancer. However, regulation of Pol III remains poorly understood in mammalian cells and cancers. This proposal studies how cell permeable hormones including progesterone and retinoic acid activate their cognate nuclear receptor transcription factors to directly regulate Pol III and alter the tRNA pool in breast cancer cells. This work will define an additional layer of coordinated nuclear receptor gene regulation that contributes to the frequent non-linear translation of messenger RNAs into protein that impacts cell growth, stemness, and cancer.

PI_NAMEs: KABOS, PETER ;SARTORIUS, CAROL ANN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Aging;Agonist;Androgens;antagonist;Binding;Biology;Breast Cancer Cell;Breast Cancer cell line;cancer therapy;Cell Differentiation process;cell growth;Cell Physiology;Cell Proliferation;Cell Survival;Cells;ChIP-seq;Chromatin;Code;Codon Nucleotides;cofactor;Complex;Data;detection of nutrient;Development;Disease;disorder control;DNA;DNA Binding;DNA Sequence;Electron Transport Complex III;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen receptor positive;Estrogen Receptors;Estrogens;Family;Feedback;Female;FRAP1 gene;Gene Expression Regulation;Genes;genetic testing;Genetic Transcription;genome-wide analysis;Glucocorticoid Receptor;Glucocorticoids;Goals;hormonal signals;Hormone Receptor;hormone regulation;Hormones;Human;inducible gene expression;knock-down;Knowledge;Ligands;Link;lipophilicity;Longevity;Malignant Neoplasms;Mammalian Cell;manufacture;Measures;Medicine;member;Messenger RNA;Metabolic Diseases;Molecular;mRNA Translation;Mutagenesis;mutant;neoplastic;Normal Cell;Normal tissue morphology;novel;Nuclear Receptor Gene;Nuclear Receptors;Oncogenic;Organism;Pathway interactions;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Play;Polymerase;Post-Transcriptional Regulation;Progesterone;Progesterone Receptors;promoter;Protein Biosynthesis;Proteins;Proteome;receptor binding;recruit;Regulation;Repression;Reproduction;retinoic acid receptor alpha;Ribosomal RNA;ribosome profiling;RNA Polymerase II;RNA Polymerase III;Role;Signal Transduction;Site;small molecule;Small RNA;stem cells;stemness;steroid hormone;Steroid Receptors;Testing;tissue stem cells;Tissues;transcription factor;Transcription Factor TFIIIB;Transcription Initiation Site;Transcription Repressor;transcriptome;Transfer RNA;translational impact;Translations;translatome;transmission process;Tretinoin;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA;Vertebrates;Work

PROJECT_TITLE: Hormone Receptor Regulation of RNA Polymerase III

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: DESPREZ, PIERRE-YVES  (contact)

PROJECT_TERMS: 3-Dimensional;3xTg-AD mouse;abeta oligomer;Adopted;Affect;Age;age group;age related;age related changes;age related neurodegeneration;Age related pathologies;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Astrocytes;Automobile Driving;Autopsy;Behavioral;Biological;Brain;brain cell;brain tissue;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Nucleus;Cell Proliferation;cell type;Cells;Chronic;Coculture Techniques;Collaborations;Complement;Complex;Data;Dementia;Development;Differentiation Antigens;Early Onset Alzheimer Disease;exosome;experimental study;Fostering;Gene Expression Profile;Genotype;Heterogeneity;Human;in vivo;Induced Neurons;induced pluripotent stem cell;Inflammation;Intervention;Knowledge;Laboratories;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolism;metabolome;metabolomics;Microglia;Monitor;Morphology;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;old mice;Organoids;Pathology;Pharmaceutical Preparations;Phenotype;Population;postmitotic;Program Research Project Grants;Proteins;Proteomics;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell analysis;Slice;small molecule;Stimulus;Stress;stressor;Structure;tau aggregation;tau Proteins;Testing;Tissues;transcriptome;Transgenic Mice


ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Regenerative Rehabilitation is the integration of principles and approaches across the fields of rehabilitation science and regenerative medicine. The integration of these two fields will increase the efficiency of interventions designed to optimize physical functioning to the benefit of a wide range of individuals with disabilities. The Alliance for Regenerative Rehabilitation Research & Training (AR3T) 2.0 will build on the momentum gained over the first cycle of funding with the goal of continuing to illuminate and seize opportunities to expand scientific knowledge, expertise and methodologies in the domain of Regenerative Rehabilitation.

PI_NAMEs: AMBROSIO, FABRISIA  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Accountability;Activities of Daily Living;Age;Attention;Awareness;Basic Science;Biocompatible Materials;career;Clinical;Collaborations;Communities;Congenital Abnormality;Country;Data Analyses;Development;Disabled Persons;Discipline;Disease;Documentation;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Ensure;Evaluation;falls;Feedback;Fostering;Foundations;functional restoration;Funding;Future;gait examination;Goals;healing;improved;In Vitro;Incubators;Individual;injured;Injury;innovation;Institution;interest;Intervention;Investigation;Journals;Knowledge;Laboratories;Machine Learning;Marketing;Measurement;mechanical stimulus;Mentors;Methodology;Methods;Mission;Monitor;multidisciplinary;Natural regeneration;new technology;novel;novel strategies;Organ;Performance;Physical Function;pre-clinical;Pre-Clinical Model;Preparation;Process;programs;Quality Control;Reader;regeneration potential;regenerative;Regenerative Medicine;regenerative rehabilitation;regenerative therapy;rehabilitation research;rehabilitation science;Rehabilitation therapy;repaired;Research;Research Design;Research Personnel;Resources;response;sabbatical;Science;Scientist;Series;Signal Transduction;social media;Specialist;Stimulus;Structure;success;symposium;Systems Analysis;technological innovation;Technology;technology validation;Text;therapy design;Time;tissue regeneration;Tissues;Training;Trauma;Treatment Efficacy;Update;webinar

PROJECT_TITLE: Alliance for Regenerative Rehabilitation Research & Training 2.0 (AR3T)


PI_NAMEs: VERDIN, ERIC M. (contact)

PROJECT_TERMS: 3xTg-AD mouse;age related;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;Astrocytes;Behavioral;Biological Assay;Brain;brain cell;brain tissue;Cell Aging;Cell Culture Techniques;Cell Physiology;cell type;Cells;Coculture Techniques;cofactor;cognitive function;Consumption;cytokine;Cytometry;Dementia;Disease Progression;DNA Repair;Endothelial Cells;Enzymes;Exhibits;extracellular;Flow Cytometry;Goals;Human;Human Amyloid Precursor Protein;Hydrolase;Immune;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;Interleukin-1;Interleukin-10;knock-down;Knockout Mice;Lead;Learning;Link;LoxP-flanked allele;Macrophage;Measures;Metabolic;Metabolic dysfunction;Metabolism;metabolome;metabolomics;Microglia;Modeling;mouse model;Mus;mutant;NADH;neural;Neurons;Normal Cell;novel;novel therapeutics;overexpression;Pathway interactions;Patients;Phenotype;Population;presenilin-1;presenilin-2;Proliferating;protein expression;Proteins;Proteomics;Publishing;Reporter;Research Design;restoration;Role;Sampling;senescence;senescence associated secretory phenotype;senescent cell;Senile Plaques;single cell sequencing;Sirtuins;tau Proteins;Testing;Time;Tissue Sample;Tissues;TNF gene;transcriptomics;Transgenic Mice;Wild Type Mouse

PROJECT_TITLE: Senescence, NAD+ decrease and Alzheimer's disease and related dementias Alzheimer's disease and related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project narrative This project uses rich multi-modal (clinical, neuroimaging, and genetic) data to develop a novel integrative modeling framework to provide statistically-principled inference, accurate personalized prediction of disease progression, and dynamic prediction update, based on new subject-specific data. This project not only facilitates the discovery and evaluation of Alzheimer’s disease (AD) variables for disease progression, but also is highly relevant for optimizing AD clinical trial design.

PI_NAMEs: LUO, SHENG  (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Behavior;Behavior assessment;behavioral and social science;Biological Markers;Brain region;Clinical;Clinical Data;Clinical Research;Clinical Trials Design;Cognition;Data;data imputation;Data Sources;data structure;design;Disease;Disease Progression;Enrollment;Evaluation;Event;Future;Genetic;Genetic Markers;genome wide association study;Goals;Grant;Heritability;high dimensionality;high risk population;Impairment;Individual;interest;Internet;Joints;longitudinal analysis;Magnetic Resonance Imaging;Measurement;Measures;Medical History;Methodology;Methods;model development;Modeling;Morphology;multimodal data;multimodality;multiple data sources;Nature;Neurodegenerative Disorders;neuroimaging;Neuropsychology;novel;Online Systems;Onset of illness;open source;Outcome;Pathogenicity;personalized management;personalized predictions;Prognosis;protective factors;Quality of life;response;Risk;Risk Factors;risk variant;Severity of illness;Single Nucleotide Polymorphism;software development;Structure;survival prediction;Therapeutic Intervention;Thick;Time;tool;Translational Research;Update;user-friendly;Variant;web based software

PROJECT_TITLE: Integrative modeling and dynamic prediction of Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Microbiome;Nutrition;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative/Relevance Human gut microbiome may significantly modulate human cardiovascular health through producing and releasing lipopolysaccharide (LPS) into human circulation, although epidemiological studies of coronary heart disease (CHD) surrounding LPS exposures are limited. The proposed research aims to narrow significant knowledge gaps by evaluating prospective associations of LPS exposures with CHD incidence and how diet, lifestyle, and human microbiome may contribute to the LPS exposures in well-characterized cohort studies of free-living individuals. Data from this research will help form individualized strategies facilitating CHD prevention.

PI_NAMEs: RIMM, ERIC B (contact);SUN, QI

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Alcohols;Amines;Atherosclerosis;Bacteroides;Bifidobacterium;Biological Assay;Biological Markers;blood lipid;Blood Pressure;Blood specimen;Cardiovascular Diseases;cardiovascular health;case control;Cause of Death;Circulation;cohort;Cohort Studies;Complex;Coronary heart disease;Data;Development;Diet;Diet Modification;Diet Records;dietary;Dietary Assessment;Dietary Factors;Dietary Fiber;Dietary Intervention;Disease Management;Effectiveness;Endothelium;Endotoxemia;epidemiology study;Escherichia;Ethnic Origin;Etiology;Eubacterium;Evaluation;experimental study;Exposure to;Feces;follow-up;Follow-Up Studies;Food;Gender;Gram-Negative Bacteria;gut metagenome;gut microbiome;gut microbiota;Half-Life;Health;Health Professional;heart disease prevention;heart disease risk;Heart Diseases;Human;human data;Human Microbiome;human population study;Immune response;immunoreaction;improved;Incidence;indexing;Individual;individual variation;Inflammation;Inflammatory;Infusion procedures;Intake;Intervention;Joints;Knowledge;Leukocytes;Life Expectancy;Life Style;Life Style Modification;lifestyle factors;lifestyle intervention;lipopolysaccharide-binding protein;Lipopolysaccharides;Measurement;Measures;Mediating;Membrane;men;metabolic endotoxemia;Metabolic Pathway;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbial composition;microbiome;microbiome composition;microbiota;middle age;mind/body;modifiable risk;novel;Nurses' Health Study;older men;older women;Olive oil preparation;Oxides;Participant;Pathway interactions;personalized approach;personalized intervention;personalized strategies;Persons;Phenotype;Physical activity;Plasma;polyphenol;prevent;Prevention Measures;Prevention strategy;Prevotella;Production;Progress Reports;prospective;Proteins;Questionnaires;Reaction;recruit;Research;response;Risk;Risk Factors;Role;Saturated Fatty Acids;stool sample;success;Taxonomy;Time;Update;validation studies;Woman;Work;Yogurt

PROJECT_TITLE: Dietary Etiologies of Heart Disease

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Although is substance use disorders are a health disparity that occurs more commonly in minority and low-income populations, underrepresented minority researchers and researchers from disadvantaged backgrounds are less like to go into research in this field and apply for funding from NIDA. This R25 grant, entitled “Next Generation Substance Abuse Disorders Research Training at Charles R. Drew University (CDU) and UCLA (NGSART-CU; to be known as SART) builds on 15 years of the NIDA funded DIDARP/MIDARP programs (PI: Friedman) in which 125 mostly minority students received a meaningful research experience in substance use disorder fields along with training and mentorship. This grant proposes to provide research opportunities and courses for skill development and mentorship primarily to undergraduates, post- baccalaureate and masters students (early-stage) and post-doctoral fellows with the goal of training the next generation of substance use disorder researchers.

PI_NAMEs: FRIEDMAN, THEODORE C (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Area;Basic Science;Behavioral;behavioral health;biobehavior;Biometry;Cancer Education Grant Program;career;Clinical;community engagement;design;Disadvantaged;disadvantaged background;Disease;Doctor of Philosophy;doctoral student;Endocrinologist;Epidemiology;experience;Faculty;faculty community;faculty mentor;Family;Funding;Future;Goals;Grant;hands on research;health disparity;Hour;Individual;Infrastructure;innovation;interest;Internist;Laboratories;Low Income Population;Marriage and Family;medical specialties;meetings;member;mentoring community;Mentors;Mentorship;Methodology;Minority;minority investigator;minority student;minority trainee;minority undergraduate;Molecular;multidisciplinary;National Institute of Drug Abuse;next generation;Nurses;Participant;Pharmacists;Physician Assistants;Physicians;Postbaccalaureate;Postdoctoral Fellow;Professional counselor;programs;Psychiatrist;Psychologist;Public Health;Research;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;Science;Series;skill acquisition;skills;social;Social Workers;sociologist;Stress;Students;Substance abuse problem;Substance Use Disorder;Time;Training;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: The Next Generation Substance Abuse Research Training at Charles R. Drew University (CDU) and UCLA (NGSART-CU)


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Suicide;Suicide Prevention

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative The literature is characterized by a dearth of information on how to reduce risk for suicide among marginalized substance using youth experiencing homelessness (YEH). Suicide is the leading cause of death among YEH and most youth do not access services that may be available to them. Therefore, this study seeks to address this gap in the research literature with the goal to identify an effective intervention that can be readily adopted by communities that serve these youth.

PI_NAMEs: SLESNICK, NATASHA  (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Address;adolescent substance use;Adopted;Adoption;Advocacy;Affect;Cause of Death;Cessation of life;Cognitive;Cognitive Therapy;Communities;Community Services;completed suicide;cost;Dangerousness;Data;Dehumanization;depressive symptoms;dosage;Drops;effective intervention;evidence base;Exclusion;experience;Feasibility Studies;Feeling suicidal;follow up assessment;follow-up;Future;Goals;health disparity;Health Services Accessibility;Homelessness;Hospitalization;human capital;improved;Individual;individual response;Intervention;Intervention Studies;Knowledge;Literature;marginalization;Mediating;Mediator;Mental disorders;Mental Health;Methods;Modeling;Outcome;Outcome Study;outreach;physical conditioning;Pilot Projects;poor health outcome;premature;Premature Mortality;prevent;prevention service;preventive intervention;primary outcome;protective factors;Race;Randomized;recruit;reducing suicide;Reporting;Research;Resources;Risk Factors;Risk Reduction;Sampling;secondary outcome;Services;services as usual;sex;Sex Orientation;Shelter facility;social;social exclusion;Stress;substance use;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Testing;Theoretical model;theories;Therapeutic Intervention;Time;treatment effect;uptake;Victimization;Vulnerable Populations;Youth

PROJECT_TITLE: Suicide Prevention with Substance Using Youth Experiencing Homelessness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(02)M]


PROJECT_TERMS: 3xTg-AD mouse;Ablation;Acceleration;Acute;Adopted;Affect;age related;age related neurodegeneration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;Astrocytes;autocrine;behavioral phenotyping;Brain;Cell Aging;Cell Communication;Cell Cycle Arrest;Cell model;cell type;Cells;Cerebrum;Coculture Techniques;Collaborations;Communication;Complement;Dasatinib;Dementia;density;Deposition;Development;Disease;Disease Progression;Electrophysiology (science);Event;Excision;Goals;Hippocampus;Human;human induced pluripotent stem cells;human model;Huntington Disease;Impairment;in vivo;Induced Neurons;induced pluripotent stem cell;Inflammation Mediators;Inflammatory;Intervention;Mass Spectrum Analysis;Memory;Memory impairment;Microglia;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neuroglia;Neuronal Differentiation;Neurons;Onset of illness;Organoids;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathology;Pharmaceutical Preparations;Phenotype;Physiology;Play;Post-Translational Protein Processing;prevent;Process;programs;Quercetin;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell analysis;Slice;Somatic Cell;stem cell model;Synapses;synaptic function;System;Systems Biology;tau aggregation;tau function;tau Proteins;tau-1;therapeutic target;transcriptome sequencing;Work

PROJECT_TITLE: Cell autonomous and non-autonomous mechanisms in Alzheimer's disease and related dementias


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The sense of smell contributes significantly to our quality of life, and the loss of smell (anosmia) - as evidenced by the widespread anosmia associated with Covid-19- can not only be dangerous but typically has profound effects on psychological and emotional well-being. This research seeks to understand how the sense of smell is processed in the brain, including probing poorly understood neural mechanisms that support odor discrimination, odor recognition, and odor memories. Moreover, deficits in odor recognition and odor memory are associated with neurodegenerative diseases, such as Parkinson's and Alzheimer's, and understanding how these processes work in the healthy brain can provide important insights into how they go wrong in the diseased brain.

PI_NAMEs: FRANKS, KEVIN  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Adaptive Behaviors;Alzheimer's Disease;Animals;Anosmia;Behavior;Behavioral;Brain;Brain Diseases;cell type;Cells;Code;COVID-19 associated anosmia;Dangerousness;Data;Discrimination;experimental study;Feasibility Studies;flexibility;Food;Goals;Impairment;insight;Learning;Libraries;Location;Medial;Memory;memory acquisition;Molecular;Morphology;Mus;neural;Neurodegenerative Disorders;neuromechanism;Neurons;novel;odor discrimination;Odors;Olfactory Pathways;operation;Parkinson Disease;Partner in relationship;Perception;Phase;piriform cortex;Play;postsynaptic;Prefrontal Cortex;prevent;Process;psychologic;Pyramidal Cells;Quality of life;Research;response;Response Generalization;Retrieval;Rewards;Rodent;Role;Series;Shapes;Smell Perception;Source;Specificity;Synapses;Testing;tool;Training;Transgenic Mice;Viral;Well in self;Work

PROJECT_TITLE: Odor Coding in Piriform Cortex

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Childhood Leukemia;Data Science;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: PHASE GENOMICS, INC.

PHR: NARRATIVE Chromosomal aberrations are essential biomarkers used to guide treatment decisions for acute myeloid leukemia patients. In this proposal we describe the use of a comprehensive method to assay chromosome aberrations at high resolution and use this information to more accurately predict the severity of disease. This information will potentially be helpful guiding decision making when making treatment decisions for patients poorly stratified by current methods.

PI_NAMEs: EACKER, STEPHEN MATTHEW (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;Artificial Intelligence;artificial intelligence model;Artificial Intelligence platform;Biological Assay;Biological Markers;Blinded;Categories;Cell Nucleus;Chromosome abnormality;Chromosome Structures;Chromosomes;Clinical;cloud based;Collection;Complex;Computer software;Cytogenetic Analysis;Cytogenetics;Data;Data Aggregation;Data Set;Decision Making;Development;Diagnostic;Diagnostic Reagent Kits;Disease;Disparate;DNA;DNA Sequence Alteration;falls;Foundations;Frequencies;Genetic Epistasis;Genome;genome-wide;Hematology;Hi-C;homologous recombination deficiency;improved;Individual;information gathering;insight;Karyotype;Karyotype determination procedure;Length;leukemia;Ligation;Link;Machine Learning;machine learning model;Malignant Neoplasms;Methods;Modeling;Mutation;Neoplasms;next generation;next generation sequencing;novel;Oncology;Outcome;patient population;Patient risk;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Phenotype;physical property;predictive test;prognostic;prognostic value;Recurrence;Research;Resolution;Risk;risk prediction;risk stratification;Sampling;Sensitivity and Specificity;Severity of illness;System;Testing;tool;training data;Translating;tumor;Unbalanced Translocation;Variant;Work

PROJECT_TITLE: AI-based AML risk stratification using next generation cytogenomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-V(13)B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative Montana is one of the most rural states in the country, and rural children suffer disproportionately from several adverse health outcomes. The Center for Prevention Research will be a sustainable Center that fosters multidisciplinary research success to inform, develop and test strategies for improving rural children's health.

PI_NAMEs: NOONAN, CURTIS WILLIAM (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Biometry;Centers for Population Health;Characteristics;Child;Child Health;Chronic Disease;Collaborations;college;computing resources;Country;Data;data acquisition;data management;data modeling;Data Sources;design;Development;Diffuse;Discipline;Disease;early childhood;early-career faculty;Electronic Health Record;Environmental and Occupational Exposure;Epidemiology;Evidence based intervention;Focus Groups;Fostering;Foundations;Funding;Future;Goals;Hand;Health;health care availability;health care service;Health Professional;Health Services Accessibility;Hospitalization;Human Resources;improved;Infant;Infant Mortality;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Lower Respiratory Tract Infection;mathematical model;Mentors;Methods;Modeling;Montana;multidisciplinary;Outcome;Performance;Pilot Projects;Population;population health;Prevention;Prevention Research;Prevention strategy;Productivity;provider networks;Qualitative Methods;Quality of life;Recruitment Activity;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Factors;Rural;Rural Community;Rural Health;Rural Population;rural setting;rurality;Social support;Structure;success;Survey Methodology;Surveys;Target Populations;Testing;therapy development;tool;tool development;Translations;urban area;Urban Community;urban setting;Vaccination

PROJECT_TITLE: Center for Population Health Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Services;Prevention;Rural Health

PROJECT_TERMS: Academic Medical Centers;Administrator;Advisory Committees;Applications Grants;Award;Benchmarking;career;career development;Centers for Population Health;Child;Child Health;Collaborations;Communication;Data;design;Development;Development Plans;Ensure;Epidemiology;Evaluation;experience;Extramural Activities;Faculty;formative assessment;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Health;improved;Individual;Infrastructure;innovation;Intervention;Intervention Studies;Investments;Leadership;leadership development;Marketing;Mentors;Mentorship;Modeling;Modification;Montana;Newsletter;outreach;Pathway interactions;Pilot Projects;Prevention Research;Process;Productivity;programs;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Support;Resource Allocation;Resources;Risk;Rural;Rural Community;skills;Structure;success;Talents;Teacher Professional Development;Testing;Training;Update;Vision;web site;Work;Writing

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: GRAHAM, JONATHAN  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Air;Area;Biometry;Centers for Population Health;Child;Child Health;Climate;cluster computing;Computerized Medical Record;computing resources;Data;data access;data acquisition;Data Analyses;Data Analytics;data centers;data management;data registry;data resource;Data Science;Data Sources;demographics;Development;disease transmission;Electronic Health Record;Environmental Monitoring;Exposure to;fine particles;Fire - disasters;Future;Geography;Health;health data;High Performance Computing;Immunization;improved;Individual;innovation;Laboratories;Manuscripts;Mathematics;Medical Records;Modeling;Montana;Outcome;Population;Preparation;Prevention Research;Prevention strategy;Provider;Records;Research;Research Personnel;Research Project Grants;Resolution;Resources;Risk;Rural;Rural Community;Rural Health;rural setting;Science;Smoke;sociodemographics;spatiotemporal;statistics;Structure;Testing;Time;Training;urban area;Vital Statistics;Wildfire;Writing

PROJECT_TITLE: Data and Modeling Core