NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Autism Spectrum Disorder (ASD) is a highly heritable, heterogenous neurodevelopmental disorder affecting 1 in 36 children, and while functional genomic analysis of post-mortem cortex from donors diagnosed with ASD reveals activation of microglia, there is little known about microglial activity in ASD during fetal brain development. This project aims to transcriptionally, functionally, and morphologically characterize the impact of ASD risk gene mutations on the patterns of microglial activation, using stem cell (SC) derived microglia combined with 3- dimensional SC cortical spheroids. These studies will identify potential mechanisms of pathophysiology of neuro- immune dysregulation in ASD and will untangle the effects of genetic risk versus the effects of cell-cell interactions on microglial activation.

PI_NAMEs: HAWKEN, NATALIE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Astrocytes;autism spectrum disorder;Autopsy;Axon;Biological Assay;Biological Models;Brain;career;Cell Communication;cell cortex;Cell Culture Techniques;Cell Line;Cell Maturation;Cell Nucleus;cell type;Cells;Cellular Morphology;Child;Classification;Clinic;Clinical;clinical training;Coculture Techniques;comparison control;Complex;Data Set;de novo mutation;Development;developmental neurobiology;Diagnosis;disorder risk;Ethics;excitatory neuron;experimental study;fetal;Fetal Development;Foundations;Functional disorder;functional genomics;Gene Expression Profiling;Gene Mutation;gene network;Genes;Genetic;genetic architecture;Genetic Risk;genetic risk factor;Genetic Transcription;glial activation;Goals;Heritability;high risk;Human;human model;human stem cells;Immunohistochemistry;In Vitro;in vivo;individuals with autism spectrum disorder;Interneurons;Knowledge;Laboratories;Lead;Maps;Measures;Mentorship;Methods;Microglia;Modeling;Morphology;multidisciplinary;mutant;Mutation;nerve stem cell;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroimmune;neuron development;Neuronal Dysfunction;Neurons;neurotransmission;novel;Organoids;pathogen;Pathogenesis;Pathologic;Pathway Analysis;Pattern;Pediatric Neurology;Phagocytes;Phagocytosis;Phenotype;Physicians;Physiology;Population;Positioning Attribute;Productivity;Proliferating;Protocols documentation;repetitive behavior;Risk;risk variant;Role;Sampling;Scientist;Secondary to;Sensory;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Social Interaction;spheroids;stem cells;Synapses;System;Testing;Thinking;Tissue-Specific Gene Expression;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Validation

PROJECT_TITLE: Functional Genomic Interrogation of Autism Spectrum Disorder Genetic Risk on Microglia-Neuronal Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Rural Health

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Co-occurring anxiety disorders affect 40 to 50% of children with autism spectrum disorder (ASD), contributing to substantial distress and impairment. Personalized cognitive-behavioral therapy (CBT) has been found to be effective for this underserved group, but it is not readily available for real-world uptake, nor are the core treatment mechanisms well understood. A scalable and effective CBT program designed to be delivered by community clinicians with limited ASD training and experience could contribute to public health efforts to address the mental health needs of the rising number of children diagnosed with ASD and anxiety.

PI_NAMEs: STORCH, ERIC A. (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Acceleration;acceptability and feasibility;access disparities;Address;adolescent with autism spectrum disorder;Adoption;Advocate;Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;autism spectrum disorder;autistic children;Behavioral;Child;Clinic;Clinical;Cognitive;Cognitive Therapy;Collaborations;Communities;community academic partnership;community building;Community Mental Health Centers;Community Mental Health Services;community setting;Complex;Consult;contextual factors;Data;design;Diagnosis;Diagnostic;Distress;Effectiveness;effectiveness/implementation trial;efficacious intervention;efficacy evaluation;Emotional;evidence base;Evidence based intervention;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Family;feasibility testing;Feedback;functional outcomes;Funding;Future;Goals;Health system;Hybrids;Impairment;implementation determinants;implementation outcomes;implementation science;improved;Individual;individuals with autism spectrum disorder;Intervention;Knowledge;Learning;Lived experience;Measurement;Medical;Mental Health;mental health center;Mental Health Services;Methods;Modeling;Needs Assessment;Neurodevelopmental Disorder;North Carolina;Outcome;Parents;personalized medicine;Phase;Pilot Projects;Play;Population Intervention;Preparation;programs;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;research to practice;rural area;Rural Community;Sampling;scale up;Services;Severities;Site;standard care;Texas;Therapeutic Intervention;Time;Training;Translating;treatment as usual;Treatment outcome;treatment program;treatment response;Underserved Population;United States National Institutes of Health;uptake;urban area;Urban Community;Work;Youth

PROJECT_TITLE: Feasibility, Preliminary Effectiveness, and Sustainability of a Cognitive-BehavioralTherapy Program Tailored for Youth with Autism and Anxiety Treated in Real-WorldCommunity-Based Clinics


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Patient Safety;Telehealth

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Multiple Sclerosis is a neurodegenerative disease that is tracked and assessed using infrequent and expensive clinical assessments and imaging studies. Capturing extra-clinical disease activity at higher frequencies using new sensors and capabilities on mobile devices can improve clinical decision making, and improve clinical researchers monitor disease activity. This work aims to develop the models and practices necessary to remotely track MS disease activity using mobile device data, and unlock our understanding of what happens outside of the clinic, thus having the potential to improve the care of patients and quality of MS research worldwide.

PI_NAMEs: HITTLE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Accounting;Acute;Address;Affect;Apple;Apple watch;Auditory;Award;Behavior;Behavioral;Bladder;Brain;burden of illness;career;Cellular Phone;Clinic;Clinical;Clinical assessments;clinical decision-making;clinical imaging;clinical predictors;Clinical Research;cognitive function;cohort;Collection;cost;Data;Data Collection;data mining;Data Sources;Decision Making;Demyelinations;Devices;dexterity;digital;digital applications;digital phenotyping;digital tool;disability;Disability scale;Disease;Disease Progression;doctoral student;Electronic Health Record;Epidemiology;Evolution;Frequencies;Goals;handheld mobile device;heterogenous data;Image;imaging study;improved;innovation;instrument;Left;Length;Machine Learning;Magnetic Resonance Imaging;Manuals;Manuscripts;Measures;Mentors;Methods;mobile application;Mobility decline;Modality;Modeling;Monitor;multidimensional data;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurologic;Neurologic Examination;Neurological disability;Outcome;Outcome Measure;Patient Care;Patient Monitoring;Patient Outcomes Assessments;Patient Self-Report;Patients;Periodicals;Persons;pharmacologic;Pharmacological Treatment;Physiological;Play;Population;predict clinical outcome;predictive modeling;prospective;prototype;Provider;Publications;Quality of life;randomized trial;Records;Recovery;recruit;Relapse;Relapsing-Remitting Multiple Sclerosis;remote monitoring;Research;Research Personnel;Resolution;Resources;Role;Screening procedure;sensor;smart device;Speed;Spinal Cord Lesions;Surveys;Symptoms;Task Performances;Techniques;Testing;Time;tool;Training;United States;Universities;Vision;Visit;Walking;walking speed;Work;young adult

PROJECT_TITLE: Precision Monitoring of Multiple Sclerosis with Mobile Devices: A Transformative Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  To this date, we are still uncovering the exact morphological and functional changes that retina cells undergo throughout retinal degenerative disease timecourse. Furthermore, as common to many neurodegenerative diseases, our knowledge is incomplete when it comes to understanding how these morphological changes to cells affects their role in neural networks, as well as the factors that impact these changes in connectivity. With this proposal, we will take what we have learned from multiscale computational modeling of extracted early data from patho-connectomes, or connectomics volumes constructed from early degeneration stages pathological or neurally degenerating tissues, and pursue large scale network creation and modeling for all four stages of retinal degeneration. These models will be integrated in our parallel multiscale Admittance Method (AM)-NEURON computational platform, which integrates modeling of exogenous electric field application with neural activity of complex networks to provide insights into the physiological consequences of morphological changes on retinal signaling.

PI_NAMEs: LAZZI, GIANLUCA  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Affect;Area;Atlases;Axon;Biological Process;Biomedical Engineering;Biomimetics;Biophysics;blind;cell type;Cells;Cessation of life;Complex;computational platform;computerized tools;connectome;connectome data;Data;Development;Devices;electric field;Electric Stimulation;Electron Microscopy;Electrophysiology (science);Eye diseases;ganglion cell;Ganglion Cell Layer;Gene Modified;Glutamates;Image;Individual;insight;Knowledge;Label;Learning;Light;Maps;mathematical model;Methods;Microscope;microscopic imaging;Modeling;Molecular Computations;molecular phenotype;Morphology;multi-photon;multi-scale modeling;Nerve Degeneration;neural;neural network;Neurodegenerative Disorders;Neurons;Oryctolagus cuniculus;Output;patch clamp;Pathologic;Pathway interactions;Phase;Phenotype;photoreceptor degeneration;Photoreceptors;Physiological;Process;Protocols documentation;Rabies;rabies viral tracing;reconstruction;Resolution;response;restoration;Retina;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;retinal prosthesis;retinal stimulation;Role;Sampling;Signal Transduction;small molecule;Therapeutic;tissue degeneration;Tissues;Tracer;Translating;Viral;Vision;Visualization

PROJECT_TITLE: Mesoscale correlative light-electron microscopy (CLEM) computational pathoconnectomes of degenerated retinas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative While unrestricted access to antiretroviral therapy (ART) has allowed people living with HIV (PLWH) in low- and middle-income countries (LMICs) to approach near-normal life expectancies, the long-term health consequences and socioeconomic burdens stemming from increased comorbidities such as diabetes mellitus (DM) in these individuals have significant implications on both an individual and national scale. Consequently, unraveling the pathogenicity linked to these comorbidities and investigating viable therapeutic and/or prophylactic strategies becomes of paramount importance. Our study will set the stage for broader-scale studies aimed at mitigating DM and other risks of non-communicable diseases in these vulnerable populations within resource-deprived settings.

PI_NAMEs: LIYANAGE, NAMAL  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Activated Natural Killer Cell;Adult;Age;Antigens;antiretroviral therapy;Asia;Atherosclerosis;Autoimmune Diabetes;Back;Beta Cell;Blood Glucose;Body mass index;Cardiometabolic Disease;Cardiovascular Diseases;Cell Physiology;Cells;Chronic;Circulation;Collaborations;comorbidity;Complications of Diabetes Mellitus;cost;Country;Cytometry;cytotoxic;cytotoxicity;Data;design;Development;diabetes management;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;Disease Progression;Dyslipidemias;Early Intervention;Economic Burden;endoplasmic reticulum stress;Epidemiology;epigenomics;Etiology;Exocrine pancreatic insufficiency;Faculty;field study;Flow Cytometry;Fostering;Frequencies;Future;Gene Expression Profile;General Population;glucose tolerance;Goals;Health;high dimensionality;HIV;Hypertension;Immune;immune activation;Immune mediated destruction;Immunity;immunopathology;Immunophenotyping;impaired glucose tolerance;Incidence;Individual;Inflammation;Inflammatory;Infrastructure;infrastructure development;Insulin Resistance;insulin sensitivity;Knowledge;Life Expectancy;Ligands;Link;Literature;low and middle-income countries;Mediating;Mediator;Medicine;Metabolic;Metformin;Microbiology;mouse model;Mus;Natural Killer Cells;neoantigens;NK Cell Activation;non-diabetic;novel;Outcome;Pancreas;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Population;Predisposition;Prevention strategy;programs;Property;prophylactic;receptor;Research;Research Infrastructure;Resources;Risk;Risk Factors;screening;Secretory Cell;socioeconomics;South Asian;Sri Lanka;stem;stress reduction;Structure of beta Cell of islet;Techniques;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;Universities;Up-Regulation;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Understanding the Mechanism of HIV Associated with Diabetic Complications in Low- and Middle-Income Country

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The coordinated sequential presentation of angiogenic growth factors is critical for angiogenesis, but many factors can disrupt the temporal regulation of proteins during natural healing cascades, resulting in poorly revascularized tissues. This project will apply a combination of computational design and drug delivery approaches to establish affinity-based biomaterials as controlled release systems that mimic the coordinated presentation of angiogenic proteins seen within a native context, providing a therapeutic approach for reconstituting the angiogenic healing cascade. The ability to tune the release of multiple proteins will provide a platform for systematically investigating how the temporal regulation of protein presentation mediates angiogenesis and has the potential to broadly enhance current therapeutic approaches to vascular tissue repair.

PI_NAMEs: SVENDSEN, JUSTIN E (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Affinity;alpha helix;Amino Acid Sequence;Amino Acids;angiogenesis;Angiogenic Proteins;arm;Biochemical;Biocompatible Materials;Biological Assay;blood vessel development;Blood Vessels;Cell Line;cell type;Cells;Chronic Disease;controlled release;Coupling;crosslink;Data;delivery vehicle;design;Development;Directed Molecular Evolution;Disease;Dissociation;Dithiothreitol;Drug Delivery Systems;Enzyme-Linked Immunosorbent Assay;FGF2 gene;Fibrinogen;Goals;Growth Factor;Growth Factor Inhibition;Harvest;healing;Hydrogels;Impairment;improved;In Vitro;in vivo;injured;insight;Kinetics;Knowledge;Luciferases;Maleimides;Measures;Mediating;Mediator;Methods;Molecular Probes;Morphogenesis;Natural regeneration;novel therapeutic intervention;Outcome;Pattern;Phase;Plasmids;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;Polyethylene Glycols;Polymers;Process;Proliferating;Protein Engineering;protein protein interaction;Proteins;Rattus;reconstitution;recruit;regenerative;Regenerative response;Regulation;release factor;Reporter;Research;Research Personnel;response;revascularization;Role;severe injury;Signal Transduction;Signaling Protein;Site;Specificity;Stimulus;System;Tertiary Protein Structure;Testing;Therapeutic;tissue injury;tissue repair;Tissues;tool;Transfection;Variant;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;Work;wound vascularization

PROJECT_TITLE: Development of affinity-based delivery systems for angiogenic growth factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Dental, Oral, and Craniofacial Disease;Osteoarthritis;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE Osteoarthritis of the temporomandibular joint of the jaw causes debilitating pain in many people, yet we currently lack any therapies to restore joint function. In contrast, zebrafish can regenerate missing cartilage at the jaw joint surface through adulthood. Characterizing the mechanism for joint cartilage regeneration in an organism with the capacity for regeneration would lead to new approaches to treat osteoarthritis of the jaw.

PI_NAMEs: OFOEGBU, OLUCHI AMARACHUKWU EBERE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Adult;Affect;arthropathies;beta Actin;Biological Assay;bone;Cartilage;cartilage cell;cartilage regeneration;Cell Death;Cell Nucleus;Cell Proliferation;cell type;Cells;Cephalic;Chondrocytes;Chromatin;Color;Connective Tissue;Data;debilitating pain;Degenerative polyarthritis;design;Deterioration;disability;Enhancers;Epiphysial cartilage;Event;Fishes;Fluorescence;Future;Gene Expression;Genetic Transcription;healing;Health;Human;Image;In Situ Hybridization;Incidence;Injury;insight;Jaw;Jaw Diseases;joint destruction;joint function;Joints;Label;Ligaments;Mammals;Mediating;Methods;Metronidazole;Modeling;Molecular;Monitor;multiple omics;Natural regeneration;Neural Crest;Nitroreductases;novel strategies;Organism;Pain;Persons;Population;prevent;Prevention;Process;progenitor;Proliferating;Property;Proteins;regeneration model;regenerative;Regenerative capacity;repaired;Reporter;Reproducibility;RNA analysis;single cell analysis;Source;Specificity;stem cell population;stem cell self renewal;stem cells;Structure;Surface;Surgical Models;System;Tamoxifen;Temporomandibular Joint;Temporomandibular Joint Disorders;Temporomandibular joint osteoarthritis;Testing;Therapeutic;Time;Tissues;transdifferentiation;Transgenic Model;Transgenic Organisms;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Identifying the cellular origins of jaw joint cartilage regeneration in zebrafish

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Distractibility poses a public health concern, impacting accident rates, productivity, and youth's academic performance. High distractibility correlates with adverse outcomes such as lower graduation rates, occupational success, income, and increased anxiety, depression and other severe mental health challenges for adolescents. This innovative project aims to quantify distraction and its effects in real-world learning contexts, enhancing our understanding of individual differences in adolescent distractibility and positioned to inform precision interventions for those significantly impaired in daily functioning.

PI_NAMEs: GENG, JOY JIA;SCHWEITZER, JULIE B. (contact);ZION GOLUMBIC, ELANA

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Accidents;Acoustic Stimulation;Adolescent;Adverse effects;adverse outcome;Affect;Anxiety;Attention;Attention deficit hyperactivity disorder;Behavior;behavior test;Behavioral;California;Categories;Clinic;Clinical;clinical practice;cognitive system;cohort;Collaborations;Comprehension;daily functioning;Data;Development;Diagnostic;digital;Dimensions;distraction;Ecological momentary assessment;Education;Educational Activities;educational atmosphere;Electroencephalography;Environment;executive function;experience;Eye;Future;gaze;General Population;Goals;Graduation Rates;Heterogeneity;high school;High School Student;Home;Impairment;improved;inattention;Income;Individual;Individual Differences;informant;innovation;Intervention;Laboratories;Learning;learning outcome;learning strategy;Life;Measurement;Measures;media use;Mental Depression;Mental Health;Methods;Mind;National Institute of Mental Health;Nature;neural;ninth grade;novel;Occupational;Outcome;Parents;Pathology;Patient Self-Report;peer;Performance;person centered;personalized intervention;Photic Stimulation;Population;Positioning Attribute;Predisposition;Productivity;Public Health;Recommendation;recruit;Reporting;Research;Research Domain Criteria;response;rumination;Sampling;Schools;Severities;Sleep;social media;Speech;Stress;Students;Subgroup;success;Symptoms;teacher;Technology;Time;tool;translational approach;Universities;virtual reality;Work;Youth

PROJECT_TITLE: Quantification of Distraction in Academic settings: A Translational Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Colorectal cancer with peritoneal metastases, once seen as terminal, is now potentially treatable with cytoreductive surgery. Innovative new strategies such as fluorescence image- guided surgery and targeted photoimmunotherapy can enhance surgical precision and provide local therapy to improve surgical outcomes in anatomically challenging areas. We plan to investigate the efficacy of a humanized anti-CEA antibody (M5A) linked to a phototoxic fluorophore (IRDye700Dx), to evaluate its efficacy in facilitating tumor removal, provide cytotoxic phototherapy, and activate a therapeutic immune response.

PI_NAMEs: CARPTEN, JOHN D. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Adverse effects;Anatomy;Antibodies;Antigen Targeting;Antigens;Area;Biodistribution;Blood;Breast;Cancer Detection;cancer surgery;cancer therapy;Cancerous;Carcinoembryonic Antigen;Cell Death;cell mediated immune response;Cetuximab;Clinical Trials;colon cancer cell line;Colorectal Cancer;Colorectal Surgery;Cytolysis;cytotoxic;cytotoxicity;density;Deposition;detection method;Development;Diagnosis;Diagnostic;Disease;Drug Kinetics;Effectiveness;efficacy evaluation;Engineering;Evaluation;Excision;experience;Failure;Fluorescence;fluorescence imaging;Fluorescent Dyes;Fluorescent Probes;fluorophore;Head and Neck Cancer;Human;human model;humanized antibody;humanized monoclonal antibodies;Image;image guided;Image-Guided Surgery;imaging study;Immune;immune activation;immune cell infiltrate;Immune response;Immunocompetent;immunogenic cell death;Immunologics;ImmunoPET;Immunophenotyping;Immunotherapeutic agent;improved;In Vitro;in vivo;in vivo imaging;innovation;Label;Lead;Lesion;Light;Link;Local Therapy;Lung;Lymphoid Tissue;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Mediating;medullary thyroid carcinoma;Mentorship;Methods;Micrometastasis;Microscopic;Modality;Molecular;Monoclonal Antibodies;mouse model;near infrared dye;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Nude Mice;Operative Surgical Procedures;Outcome;overexpression;Pancreas;Patient-Focused Outcomes;Patients;Pattern;Peritoneal;photoimmunotherapy;Phototherapy;Predictive Factor;programs;Prostate;Recurrence;Relapse;response;Scientist;Series;side effect;Specificity;Stains;Stomach;Structure;Surgeon;surgery outcome;Tactile;targeted imaging;Technology;theranostics;Therapeutic;Time;Tissues;Transgenic Mice;tumor;Tumor Debulking;Tumor Markers;tumor-immune system interactions;Visual;Visualization

PROJECT_TITLE: NCI Early-stage Surgeon Scientist Program (ESSP)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Home dialysis (commonly provided as peritoneal dialysis, PD) can provide similar or better quality of life to Veterans with kidney failure at lower costs to VA, compared to in-center hemodialysis. Yet, only 5% of Veterans with kidney failure choose PD—compared to 17% of civilians—and Black patients are 31% less likely to choose PD compared to White patients. The objective of this CDA is to characterize barriers along the journey to PD to inform an approach to co-design and pilot-test a Veteran peer support program that may equitably empower Veterans to consider PD. The peer support program will incorporate the perspective of a diverse group of Veterans and VA clinicians to improve the likelihood that the implementation strategy will equitably reach marginalized Veterans with kidney failure. This CDA will provide me with a skillset in advanced qualitative methods, human-centered design, and implementation science trials so that I can transition to independence and conduct research to address inequities in home dialysis access, use, and quality within VA.

PI_NAMEs: REDDY, YUVARAM NELLORE VILAMBI (contact)

PROJECT_TERMS: Address;Adoption;Affect;American;black patient;Black race;care delivery;Caring;Chronic Disease;Clinic;Clinical;Cluster randomized trial;Community Healthcare;cost;Cost Analysis;Country;Data;Death Rate;design;Dialysis patients;Dialysis procedure;Economics;Education;Educational workshop;Electronic Health Record;Eligibility Determination;empowerment;Engineering;Ensure;Equitable healthcare;Equity;Evaluation;Evidence based practice;Face;Goals;Hares;Health;health equity;Heart failure;Hemodialysis;Home;Home Care Services;human centered design;implementation evaluation;implementation science;implementation strategy;implementation trial;improved;Inequity;innovation;insight;Interview;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Lead;Life;Lived experience;marginalization;Medicare;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Methods;Minority;Modeling;novel strategies;Outcome;Participant;Pathway interactions;patient safety;Patients;Pattern;payment;peer;peer support;Peritoneal Dialysis;Phase;pilot test;Policies;programs;Qualitative Methods;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Sampling;secondary outcome;Site Visit;skills;Source;Specialist;Structure;System;Testing;tool;Training;Travel;Veterans;Visit;Work

PROJECT_TITLE: Drive Home: Developing Strategies for Equitable Veteran Access to Home Dialysis

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Hematology;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE  Islet transplantation to replace β cells is an attractive and FDA-approved alternative to insulin therapy for treatment of type 1 diabetes. However, this approach faces formidable challenges, including the absence of safe, non-toxic methods to shield transplanted allogeneic donor islets from immune rejection and a scarcity of donor material. To that end, this study will optimize our novel low intensity conditioning protocol for mixed chimerism by reducing or eliminating conditioning radiation, and by interrogating the immunogenicity and potential of stem cell-derived islet-like cells to reverse diabetes in mixed hematopoietic chimeras.

PI_NAMEs: RAMOS, STEPHAN ANTHONY (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adolescent;Adopted;Adverse effects;Affect;Allogenic;Allograft Tolerance;Antibodies;Antigens;Autoimmune Diseases;Autoimmunity;Beta Cell;Biological Assay;Bone Marrow;Bone Marrow Ablation;Caregivers;CD47 gene;cell replacement therapy;Cell Therapy;Cells;Chemotherapy and/or radiation;Child;Chimera organism;Chimerism;chronic pancreatitis;Clinical;clinical translation;Clinical Trials;conditioning;Cytotoxic agent;Dedications;Defect;Development;Diabetes Mellitus;diabetes mellitus therapy;Diabetic mouse;differentiation protocol;Disease;Dose;ES Cell Line;euglycemia;Face;FDA approved;Future;Generations;graft vs host disease;Hematopoietic;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;human pluripotent stem cell;Immune;Immune Tolerance;immunogenicity;immunoregulation;Inbred BALB C Mice;Insulin;Insulin-Dependent Diabetes Mellitus;islet;islet allograft;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;JAK1 gene;Life;Major Histocompatibility Complex;Malignant Neoplasms;Methods;Monoclonal Antibodies;Mouse Embryonic Stem Cells;mouse model;Mus;non-diabetic;novel;Organ;Outcome;Patients;Pharmaceutical Preparations;Pluripotent Stem Cells;Population;portability;programs;Proto-Oncogene Protein c-kit;Protocols documentation;Radiation;Radiation Dosage;Radiation Dose Unit;Radiation exposure;Regimen;Reporter;Research;Research Personnel;Risk;Solid;Source;stem cell exhaustion;stem cells;T-Cell Depletion;T-Lymphocyte;Techniques;Time;Tissue Donors;Tissues;tool;Total Pancreatectomy;Toxic effect;Training;Translations;Transplant Recipients;Transplantation;Transplantation Tolerance;Whole-Body Irradiation;Work

PROJECT_TITLE: Optimized bone marrow conditioning and tolerance assays to advance cell-based therapies for diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: RICHARDSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Narrative To build the next generation of methods to put medicine into the brain and solve the most challenging and impactful neurological diseases, we need to overcome the blood-brain barrier (BBB), the biggest barrier to delivering medicine to the brain. This study aims to investigate a cell type-specific method using the magnetic field to control the BBB and allow the medicine to enter the brain. The success of this work would lay the foundation for subsequent developments to cross the BBB and treat brain diseases.

PI_NAMEs: LIU, CHUNLEI ;QIN, ZHENPENG  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Actins;Address;adenovirus mediated delivery;Area;Binding;Biochemical;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain Diseases;brain endothelial cell;brain parenchyma;Calcium;Calcium Signaling;Cell Line;cell type;Cells;Cerebral endothelium;chemotherapy;Clinical;Clinical Trials;Coin;Complex;cranium;Cytoskeleton;Development;Diffusion;dosage;Drug Delivery Systems;Drug Modulation;Electrical Resistance;Endothelial Cells;Endothelium;extracellular;Ferritin;Focused Ultrasound;Foundations;Gases;Gene Delivery;Genes;Glycocalyx;Goals;Human;Image;imaging modality;In Vitro;in vivo;in vivo evaluation;Injections;innovation;Investigation;Ion Channel;Iron;Kininogens;Label;Lasers;magnetic field;Magnetic Resonance Imaging;Magnetism;MAPK3 gene;Measures;Mediating;Medicine;Membrane Fusion;Membrane Proteins;Methods;Microbubbles;Monitor;monolayer;nanoGold;nanoparticle;Nervous System Disorder;next generation;novel strategies;particle;Penetration;Permeability;Pharmaceutical Preparations;Phosphorylation;Physiological;polymerization;Polymers;portability;Property;Protein Kinase;receptor;remote control;Reporting;Research;RF coil;Rodent;Role;safety and feasibility;seal;Signal Induction;Signal Transduction;spatiotemporal;Stretching;success;System;Technology;Testing;Therapeutic;Tight Junctions;Tissues;Traction;transcytosis;TRP channel;TRPV1 gene;Vascular Endothelial Cell;Vascular Endothelium;Viral;virus testing;Work

PROJECT_TITLE: Modulating Blood-Brain Barrier Permeability by TRPV4 activation

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: There are over 1 million blind people in the United States and the National Eye Institute estimates this number will increase to about 4 million by 2050. According to the VA Office of Blind Rehabilitation Services, there are approximately 130,000 US Veterans who are legally blind and more than one million who have lost the ability to perform daily tasks because of low vision. This project develops and tests a new type of AI-supported visual assistive device, named AEyes, for individuals with blindness and low vision. It takes advantage of recent advances in artificial intelligence including computer vision, machine learning, optical character recognition, speech recognition, and 3D sound rendering to give the user the ability to recognize, locate, and interact with objects and people in their vicinity. AEyes will significantly increase the confidence and independence of its users.

PI_NAMEs: ROSLER, DAVID M. (contact)

PROJECT_TERMS: 3-Dimensional;Address;Age;Algorithms;Architecture;Artificial Intelligence;Auditory;Automobiles;blind;Blindness;Canes;Cellular Phone;Central Scotomas;Clothing;Color;communication device;Complete Blindness;Computer software;Computer Vision Systems;Computers;convolutional neural network;cost;Cues;detector;Development;Device or Instrument Development;Devices;Diabetic Retinopathy;effective therapy;Effectiveness;Electrical Stimulation of the Brain;Electrodes;Environment;experience;Eyeglasses;Face;Feedback;Focus Groups;Glaucoma;Goals;grasp;Hand;Head;Healthcare Systems;Home;Implant;improved;Individual;Instruction;interest;Internet;Interview;Intuition;Language;Learning;Legal Blindness;legally blind;Light;Location;Machine Learning;Macular degeneration;Microcomputers;Names;National Eye Institute;neural network;novel;object recognition;open source;Operative Surgical Procedures;optical character recognition;Paper;Perception;Performance;Peripheral;Persons;prototype;Quality of life;Reader;rehabilitation service;Research;Residual state;Resolution;Retina;Retinitis Pigmentosa;Robotics;Self-Help Devices;sensor;sight restoration;smartphone application;social;Software Engineering;sound;Specific qualifier value;speech recognition;surgical risk;System;system architecture;Tactile;Technology;Terrorism;Testing;Text;Training;Unemployment;United States;Universities;Veterans;Video Games;Vision;Vision Disorders;Visual;Visual Cortex;Visual impairment;Visually Impaired Persons;voice recognition

PROJECT_TITLE: Development of an AI Assistant for Individuals with Low Vision and Blindness

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Many couples have difficulty communicating about cancer-related concerns, which can impede their ability to cope with the disease, lead to increased psychological distress, and negatively impact the quality of their relationships. While efficacious, couple-based communication interventions have limited uptake due to their time-intensive nature; the proposed research project aims to address this problem by developing and pilot testing a text-messaging communication micro-intervention to increase reach and participation in couples coping with advanced cancer. If successful, we will have developed a brief, targeted, and scalable intervention that could be integrated into routine oncology care, resulting in better outcomes for both patients and their family caregivers.

PI_NAMEs: LEO, KARENA  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Address;Adherence;Advanced Malignant Neoplasm;Area;arm;Back;Behavior Therapy;Cancer Control;cancer diagnosis;Cancer Intervention;Cancer Survivorship;Caring;Cellular Phone;Communication;Communication difficulty;Communities;Computers;Control Groups;coping;Couples;Cultural Sensitivity;Data;demographics;Development;Diagnosis;Disclosure;Disease;Educational Materials;equity, diversity, and inclusion;ethnic minority;ethnic minority population;Exercise;experience;Family Caregiver;Feedback;flexibility;Focus Groups;Goals;Health;Health behavior change;health equity;Health Promotion;Hour;improved;Individual;innovation;Internet;Intervention;Interview;Lead;Literature;Low income;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Medical;Minority Groups;mobile application;National Cancer Institute;Nature;Oncology;Outcome;Outcome Measure;Participant;Patient Recruitments;Patients;Persons;Pilot Projects;pilot test;post intervention;Problem Solving;Process;Productivity;psychologic;Psychological adjustment;psychological distress;psychosocial development;racial minority;racial minority population;Randomized;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;research study;Resources;retention rate;satisfaction;Schedule;Services;skills;skills training;Support Groups;Target Populations;Telephone;Testing;Text Messaging;text messaging intervention;theories;therapy development;Time;Training;Transportation;Travel;Underserved Population;uptake;videoconference;Waiting Lists;Work

PROJECT_TITLE: Text-messaging Communication Micro-Intervention for Couples Coping with Advanced GI Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Malaria remains one of the great global health problems today, with hundreds of millions of new infections and over half a million deaths occurring annually. Eradication of this disease will require a combination of strategies, including means to halt the transmission of the malaria parasite from sick individuals to the mosquitoes that spread the disease to others. This research will identify proteins expressed in the malaria parasite that can be targeted with new vaccines to prevent transmission.

PI_NAMEs: SATHER, D. NOAH;SWEARINGEN, KRISTIAN EDWARD (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Animals;Anti-malarials;Antibodies;Antigens;asexual;Blocking Antibodies;Blood;Catalogs;Cell Culture Techniques;Cessation of life;Chemicals;clinical development;Clinical Trials;Culicidae;Data;Development;Disease;Disparity;Economics;Erythrocytes;Exhibits;extracellular;Fertilization;Future;Gene Expression;gene product;Germ Cells;global health;Goals;Human;Immune;Immune response;Immune Sera;Immunize;immunogenic;Immunoprecipitation;In Vitro;Incidence;Individual;Infection;Infection prevention;Intervention;Knowledge;Label;Licensing;Malaria;malaria transmission;malaria transmission-blocking vaccine;Malaria Vaccines;Mass Spectrum Analysis;Membrane Proteins;Methods;Midgut;Modeling;mortality;Mus;National Institute of Allergy and Infectious Disease;novel;novel vaccines;Parasites;pathogen;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;prevent;Preventive measure;Probability;protein expression;Proteins;Proteome;Proteomics;Recombinant Proteins;Recommendation;Research;Rodent;Serum;Surface;Surface Antigens;Testing;tool;transcriptome;transmission blocking;transmission process;transmission-blocking vaccine;trend;United States National Institutes of Health;Vaccinated;Vaccine Antigen;vaccine candidate;vaccine development;vaccine discovery;Vaccines;vaccinology;vector;vector mosquito;vector-borne;Work;zygote

PROJECT_TITLE: Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: AUSTIN

ORG_NAME: CLINICAL DATA INTERCHANGE STAND/CONSORT

PHR: 8. Project Narrative This proposed project is a continuation of the collaboration between CDISC and CTP formed to develop the Tobacco Implementation Guide (TIG) v1.0. This project will build upon prior work done in collaboration with CTP and directly address overarching project goals and objectives leveraging innovative tools and technologies (development of Biomedical Concepts (BCs), CDISC Library, the Operational Data Model (ODM), Analysis Results Standards (ARS) and CDISC Open Rules Engine (CORE)). Leveraging previous experience and a well-established governance and open consensus-based standards development process, CDISC will engage stakeholders to achieve the following aims: Aim 1- Initiation of stakeholder adoption and further refinement of TIG v1.0 CDISC standards for submissions to CTP through (eSubmission) pilot to provide implementation support; Aim 2- Development of a documented framework for long-term collaboration, support, and refinements to TIG v1.0 standards for subsequent e-Submissions and other data standardization needs; Aim 3- Provision and creation of educational content to promote support understanding of the value of data standards in research and to support consistent implementation of TIG v1.0 standards for submissions to CTP.

PI_NAMEs: CONNOLLY, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: CAI, YING

PROJECT_TITLE: An eSubmission pilot with stakeholder education to ensure successful adoption of data standards by regulators, industry, and global organizations for tobacco research, regulatory review, data sharing.

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CTP-T (01)]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative An deficit in understanding of the molecular events that contribute to the development of diabetic retinopathy represents an obstacle to the design and implementation of therapeutics that more fully address its molecular pathogenesis. The present application will identify a novel mechanism that regulates the antioxidant and inflammatory responses of the retina. These findings are expected to provide new targets for intervention and lead to the development of innovative therapies that target a leading cause of blindness.

PI_NAMEs: DENNIS, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acetylation;Address;Allosteric Regulation;Antioxidants;Artificial Intelligence;Binding;Biochemical;biological adaptation to stress;Biological Assay;Blindness;Calcium;Cations;Cells;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Cyclic GMP;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;disulfide bond;DNA;DNA Damage;Docking;Down-Regulation;Early Intervention;Epitopes;Event;evidence base;Exposure to;Failure;Funding;genetic approach;GLAST Protein;Gliosis;Glutamates;Glycogen Synthase Kinase 3;glycogen synthase kinase 3 beta;Homeostasis;Hyperglycemia;immune activation;improved;Inflammatory;Inflammatory Response;Innovative Therapy;insight;Intervention;knock-down;Knock-in Mouse;Knockout Mice;Laboratories;macular edema;Mediating;Messenger RNA;Mitochondria;Mitochondrial DNA;mitochondrial permeability transition pore;Modeling;Modification;Molecular;molecular dynamics;Muller's cell;Mus;Nerve Degeneration;novel;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Permeability;Phosphotransferases;Play;Point Mutation;pre-clinical;prevent;Production;Proteins;Proteolysis;Reactive Oxygen Species;receptor;response;Retina;Retinal Defect;Retinal Diseases;ribosome profiling;Ribosomes;RiboTag;Role;sensor;Signal Transduction;Small Interfering RNA;small molecule;small molecule inhibitor;standard of care;Stimulator of Interferon Genes;Stress;Synapses;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Up-Regulation;uptake;Variant;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vision;visual dysfunction;Visual impairment

PROJECT_TITLE: Redox-sensitive activation of REDD1 in diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Glioblastoma (GBM) is a lethal brain cancer with no effective treatment available due to its highly immunosuppressive microenvironment, which remains uncharacterized. We will use a novel, genetically accurate immunocompetent syngeneic mouse model of GBM to study the role of the immune response modulators TREM1 and TREM2 in regulating the composition and function of immune cells in GBM and their influence on GBM growth and survival. This research will determine the potential role of interference with TREM1/2 for treatment of GBM.

PI_NAMEs: CHAREST, ALAIN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Agonist;Alleles;Allogenic;Allografting;antagonist;bone cell;Bone Marrow;Cell Compartmentation;Cell Differentiation process;Cell Physiology;Cell Surface Receptors;cell type;Cells;Clinical Management;Disease;Drug Receptors;Drug resistance;effective therapy;Emergency Situation;Engraftment;Epidermal Growth Factor Receptor;Family;Flow Cytometry;Future;Genetic;Genomics;Glioblastoma;Goals;granulocyte;Growth;Hematology;Hematopoietic;Heterogeneity;Human;Immune;immune checkpoint blockade;Immune Evasion;immune function;Immune response;Immune system;Immunocompetent;Immunotherapeutic agent;Immunotherapy;Intervention;Invaded;Knowledge;Left;Macrophage;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Measurable;Microglia;Modeling;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;novel;Patients;pharmacologic;Prognosis;rapid growth;receptor;Research;Resistance;response;Role;Therapeutic;Therapeutic Intervention;Tissues;Transgenic Mice;Treatment Failure;TREM2 gene;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Deciphering TREM1/2 Function in Primary Brain Cancer Using a New Model of Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-V (03)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Transcription requires the coordinated assembly of many components in space and time. Phase separation has recently been implicated in this process, but it remains unclear through which mechanisms it contributes to transcription. Here, we will characterize the contributions of phase separation to inclusion and exclusion of regulators, to changes in chromatin structure and to driving transcriptional activity, with implications for the development of therapeutics that target transcriptional processes in diseases.

PI_NAMEs: ANSARI, ASEEM Z;MITTAG, TANJA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Automobile Driving;Behavior;Binding;Binding Sites;Biological Process;Cell Extracts;Chromatin;Chromatin Structure;Complex;Development;Disease;Distant;DNA;driving force;Elements;Exclusion;Gene Expression;Genetic Transcription;In Vitro;in vivo;Individual;interest;Investigation;Literature;loss of function;Mediating;Mediator;Modeling;Molecular;Mutagenesis;mutant;Mutation Analysis;Outcome;Pathologic;Phase;Physical condensation;Physiological;Process;promoter;Property;reconstitution;recruit;Regulation;Regulatory Element;Reporting;Role;Solubility;stem;System;Testing;Therapeutic;therapeutic development;therapeutic target;Time;transcription factor;Transcription Process;transcriptome sequencing;Variant;Work;Yeasts

PROJECT_TITLE: Dissecting the contributions of phase separation to yeast transcription .

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: PROJECT NARRATIVE People with HIV (PWH) are at increased risk of developing coronary artery disease (CAD) due to an accelerated inflammatory process resulting in formation of non-calcified plaques, not easily detected by standardized diagnostic methods. Pericoronary adipose tissue (PCAT) may serve as a feasible alternative imaging technique for early detection of coronary inflammation and CAD in people with HIV (PWH). This project will leverage data from two established cohorts to determine relationships between HIV-related inflammation, PCAT, and subclinical CAD among PWH in Uganda.

PI_NAMEs: BIBANGAMBAH, PROSSY KYASIMIRE (contact)

PROJECT_TERMS: Acceleration;Address;adipokines;Adipose tissue;Affect;Africa South of the Sahara;African;Angiography;antiretroviral therapy;aqueous;Area;Arterial Fatty Streak;Atherosclerosis;atherosclerosis risk;attenuation;automated segmentation;Award;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;Clinical;Clinical Research;co-infection;cohort;Cohort Studies;Collection;Communities;comorbidity;Complex;Computer software;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary artery calcium;coronary computed tomography angiography;coronary plaque;cytokine;Data;density;Development;Diagnostic;Diagnostic Procedure;Diffuse;Disease;disorder risk;Early Diagnosis;Evaluation;Event;experience;Faculty;feature selection;fitness;Functional disorder;Funding;Future;Goals;HIV;imaging modality;imaging Segmentation;Imaging Techniques;improved;Inflammation;Inflammatory;innovation;insight;interest;Lesion;lipid biosynthesis;Lipids;Machine Learning;machine learning algorithm;Manuscripts;Mentors;Mentorship;Methods;Modality;Modeling;Morbidity - disease rate;mortality;novel;Outcome;Participant;particle;Pathogenesis;Performance;Persons;Positioning Attribute;Process;prospective;Publishing;radiologist;radiomics;Research;Research Personnel;Research Priority;Risk;Risk Factors;risk prediction;risk stratification;Science;Scientist;skills;Standardization;Statistical Methods;Stenosis;Technology;tissue biomarkers;Training;Uganda;United States National Institutes of Health;Universities;vascular inflammation

PROJECT_TITLE: Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Narrative Loss of sensory hair cells leads to hearing loss and vestibular problems. In contrast to mammals, zebrafish regenerate sensory hair cells. Elucidating the gene regulatory networks controlling zebrafish hair cell regeneration will help us to design therapeutic strategies to induce hair cell regeneration in humans.

PI_NAMEs: PIOTROWSKI, TATJANA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Amphibia;Appearance;Binding;Biological Models;Birds;Cause of Death;cell behavior;Cell Death;Cell Differentiation process;Cell Lineage;cell type;Cells;Cellular Morphology;Chromatin;cofactor;CRISPR/Cas technology;Crista ampullaris;Data;Defect;design;Development;directed differentiation;Ear;Enhancers;Epithelium;Event;Evolution;experimental study;Fishes;Gene Activation;Gene Expression;gene interaction;gene regulatory network;Genes;Genetic Epistasis;hair cell regeneration;Hair Cells;hearing impairment;Hearing problem;Human;In Situ Hybridization;Injury;Inner Hair Cells;insight;insulinoma associated 1;Knowledge;lateral line;Life;Link;Mammals;Modeling;Molecular;Morphology;multiple omics;Mus;mutant;Natural regeneration;Organ;Organoids;Outer Hair Cells;overexpression;Play;Predictive Factor;Production;Reaction;regenerative;Regulatory Element;Repression;Role;Saccule and Utricle;Sampling;Sensory;Sensory Disorders;Sensory Hair;single-cell RNA sequencing;Skin;Specific qualifier value;stem cells;Supporting Cell;System;Techniques;Testing;Therapeutic;Time;transcription factor;transcriptome;Utricle structure;Vestibular Diseases;Vestibular dysfunction;Zebrafish

PROJECT_TITLE: Zebrafish Sensory Hair Cell Regeneration

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Neurosciences;Women's Health Research

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative Vasoregulation is a physiological mechanism that adjusts the diameter of small muscular arteries and arterioles to maintain optimal blood flow and pressure. This proposal aims to secure financial support for a conference that will unite basic and translational scientists across diverse disciplines, facilitating the exchange of cutting-edge findings pertaining to vasoregulation in health and disease.

PI_NAMEs: EARLEY, SCOTT  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Address;Arizona;Arteries;arteriole;Astrocytes;Atherosclerosis;Award;Beauty;Biophysics;Blood flow;Blood Pressure;Blood Vessels;Brain;Cardiovascular Diseases;cardiovascular health;career;career development;cell type;Cerebral small vessel disease;Collaborations;Communities;cost;Country;Diameter;Discipline;Disease;Elements;Endothelial Cells;Ensure;Environment;Europe;Event;Financial Support;Fostering;Foundations;Functional disorder;Genetic;Goals;graduate student;Health;Health Sciences;Hypertension;in vivo;innovation;Investigation;Ion Channel;lectures;Location;long-standing disparities;medical schools;meetings;Mentors;Mentorship;Microvascular Dysfunction;Minority Groups;Minority Participation;Minority Women;Molecular;Muscle;Names;National Heart, Lung, and Blood Institute;Neurons;Neurosciences;Nevada;North America;novel;Paris, France;Pathologic;Pathology;Pathway interactions;Pericytes;Physiological;Physiological Processes;Physiology;Postdoctoral Fellow;posters;Price;Prize;Process;programs;Recreation;Regulation;Research;Research Personnel;Resort;Role;Schedule;Science;Scientist;Secure;Series;Signal Transduction;Site;Smooth Muscle;stem;structural biology;symposium;synergism;Tennessee;translational scientist;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Vascular Diseases;Vascular Smooth Muscle;Woman;Work

PROJECT_TITLE: Vasoregulation: Signaling and Multicellular Inputs

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SHERMAN OAKS

ORG_NAME: TRETHERA CORPORATION

PHR: PROJECT NARRATIVE Acute disseminated encephalomyelitis (ADEM) is an autoimmune disease driven by activated lymphocytes with significant morbidity and mortality and no FDA-approved therapy for its treatment. Our company, Trethera, is developing a novel small molecule drug, TRE-515, to treat ADEM by targeting a pathway required for lymphocyte proliferation. In the proposed project, we will conduct critical preclinical studies to further evaluate TRE-515 in an advanced mouse model of ADEM and to conduct IND-enabling juvenile toxicology studies.

PI_NAMEs: SCHULTZ, KENNETH  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 4 year old;8 year old;Activated Lymphocyte;Acute Disease;Acute Disseminated Encephalomyelitis;Adolescent;Adrenal Cortex Hormones;Adult;Adverse effects;Adverse event;Affect;Age;Antigens;appropriate dose;Ataxia;Autoimmune Diseases;Automobile Driving;autoreactivity;Award;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Behavioral;Biological Assay;CD4 Positive T Lymphocytes;cell type;Cells;Central Nervous System;Child;Childhood;Clinical;Clinical Trials;Coma;Data;Death Rate;Deoxycytidine;Deoxycytidine Kinase;Deoxyribonucleosides;Deoxyribonucleotides;design;Development;Disease;disease phenotype;Disease remission;DNA biosynthesis;Dose;Drug Evaluation;Drug Targeting;early detection biomarkers;effective therapy;Enzymes;Experimental Autoimmune Encephalomyelitis;FDA approved;Fever;Grant;Hospitals;Human;Hypotension;Immune;immune cell infiltrate;Immune system;Immunization;improved;in vivo;Infection;International;juvenile animal;Knock-out;Lead;Lymphocyte;lymphocyte proliferation;mature animal;Measures;Medical;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myelin;No-Observed-Adverse-Effect Level;novel;novel therapeutics;nucleoside inhibitor;Oncology;Oral Administration;Organ;Orphan Drugs;Paralysed;Pathway interactions;patient population;Patients;pediatric patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Pilot Projects;Plasma;Population;Positron-Emission Tomography;potential biomarker;pre-clinical;preclinical study;Prognosis;prophylactic;radiotracer;Rare Diseases;Recurrence;Recurrent disease;Regulatory T-Lymphocyte;response;Role;Safety;safety study;Sampling;side effect;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;Solid Neoplasm;success;Symptoms;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Tachycardia;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Toxicokinetics;Toxicology;Unconscious State;validation studies;Virus Diseases;Work

PROJECT_TITLE: Development of a novel, targeted small molecule inhibitor of the nucleoside salvage pathway through IND enabling studies and translational mouse models for acute disseminated encephalomyelitis (ADEM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: HIGHLAND INSTRUMENTS, INC.

PHR: Project Narrative The USA is suffering a national crisis of opioid addiction. This study builds on our ongoing work on electrosonic stimulation (ESStim™), a novel form of noninvasive brain stimulation, with the goal of bringing a non-pharmacological Opioid Use Disorder treatment to the market.

PI_NAMEs: DIPIETRO, LAURA ;WAGNER, TIMOTHY ANDREW (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Abstinence;addiction;Adverse event;Anxiety;Applications Grants;Authorization documentation;Back;Behavior;Behavior assessment;Behavioral;Brain;Cessation of life;Clinical;commercialization;computer studies;Confidential Information;Coupling;craving;Data;Death Rate;density;design;document outlines;Dose;Double-Blind Method;double-blind placebo controlled trial;Drug usage;economic cost;Electroencephalography;Electromagnetics;Electrophysiology (science);Epidemic;Equipment and supply inventories;Feasibility Studies;Fentanyl;follow-up;Frequencies;Goals;Grant;Hamilton Rating Scale for Depression;Health;human subject;illicit opioid;Image;improved;Impulsivity;instrument;Interview;Left;Linear Regressions;Marketing;Measurement;Methadone;Modeling;Modification;Motivation;neural;Neurologic;noninvasive brain stimulation;novel;Obsessive compulsive behavior;Opiate Addiction;opioid epidemic;opioid overdose;opioid use;opioid use disorder;outcome prediction;Overdose;overdose death;Participant;Patient Self-Report;Patients;pharmacologic;Phase;phase 2 study;placebo controlled study;Prefrontal Cortex;primary endpoint;Process;prognostic;Protocols documentation;psychosocial;Psychosocial Assessment and Care;Questionnaires;Research;response;Rest;Rights;Safety;safety assessment;safety testing;Sample Size;Sampling;Self Assessment;Site;Small Business Innovation Research Grant;Source;Stratification;Substance abuse problem;synthetic opioid;Technology;Testing;Therapeutic Effect;timeline;Tissues;trial design;Ultrasonics;United States National Institutes of Health;Update;Urine;Validation;Work

PROJECT_TITLE: Noninvasive Brain Stimulation for Treating Addiction (Supplement)


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Fibrosis is a common clinical complication resulting from injury or disease and is responsible for numerous deaths each year. Despite advances in our scientific understanding of fibrosis, there remain gaps in our knowledge that need to be addressed to facilitate clinical development of new therapies for patients. This Keystone Symposia conference continues to serve as an engaging platform for researchers from across the globe to exchange ideas, showcase pioneering findings, and build lasting collaborations focused on clinical innovations, immunobiology, and mechanobiology in the field of fibrosis research.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Acceleration;Address;Affect;Area;Artificial Intelligence;Basic Science;Body System;Canada;career;career development;Cells;Cessation of life;Clinic;Clinical;clinical development;clinical practice;Collaborations;Communities;community building;Complication;Coupled;Data;Data Set;Development;Diagnosis;Disease;drug discovery;Educational workshop;Electronic Medical Records and Genomics Network;Europe;Fibroblasts;Fibrosis;Fostering;Future;Goals;Heterogeneity;human disease;Immunobiology;improved;Industry;Inflammation;Inflammatory;Injury;innovation;insight;Interdisciplinary Study;International;Knowledge;Learning;Macrophage;meetings;member;Mentors;Methodology;Molecular;multiple omics;Natural regeneration;new technology;North America;novel therapeutics;Organ;Outcome;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;posters;programs;Proteomics;repaired;Research;Research Personnel;Resolution;Scientist;Series;Solid Neoplasm;sound;symposium;Systems Biology;Therapeutic;therapeutic target;tissue injury;tissue repair;Tissues;Training;translational approach;Translational Research;Work

PROJECT_TITLE: Fibrosis: Inflammation, Drivers, and Therapeutic Resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


PHR: PROJECT NARRATIVE Positive-strand RNA viruses are an important global health priority and research in this area has been accelerated by the COVID-19 pandemic along with the influx of new knowledge and technologies. This conference will review recent advancements in scientific research on positive-strand RNA viruses and provide an overview of the latest in vaccine and antiviral treatment modalities. Finally, this conference will facilitate connections between researchers, institutions, and industries worldwide, fostering collaborative efforts that transcend geographical constraints to address the global threat posed by these viruses.

PROJECT_TERMS: Acceleration;Address;Area;career development;catalyst;Clinical;clinical development;clinical practice;Collaborations;COVID-19 pandemic;Development;Discipline;Educational workshop;Environment;equity, diversity, and inclusion;Evolution;experience;Exposure to;Fostering;frontier;Generations;Geography;global health;Health Priorities;Human;Immunity;Immunology;improved;Industry;innovation;insight;Institution;Ireland;Knowledge;Learning;lectures;meetings;Methodology;Modality;Molecular;Molecular Genetics;multidisciplinary;Nature;next generation;novel;Outcome;Participant;Pathogenesis;posters;Research;Research Personnel;RNA;RNA Viruses;Scientific Advances and Accomplishments;Scientist;structural biology;symposium;Techniques;Technology;technology development;therapeutic target;Training;Transcend;vaccine development;Vaccine Research;Vaccines;vaccinology;Viral;Viral Pathogenesis;virology;Virus;virus host interaction

PROJECT_TITLE: Positive Strand RNA Viruses: Interdisciplinary Advances in Virology, Pathogenesis, Immunology, and Technology Development


NIH_SPENDING_CATS: Immunization;Vaccine Related

PHR: PROJECT NARRATIVE Innate immune memory, the ability of cells to recall past encounters with pathogens or stressors and to respond more quickly or effectively to a subsequent exposure, is recognized as a central feature of the immune system, yet we are just beginning to unravel the mechanisms and consequences of these pathways. The complexity and rapid progress of this field necessitate a forward-looking symposium that unites experts from diverse disciplines. Therefore, this conference is designed to catalyze new collaborations, foster the development of upcoming researchers, and showcase state-of-the-art technological platforms, all contributing to a deeper and more integrated understanding of this vital area of biomedical science.

PROJECT_TERMS: adaptive immunity;Area;Biology;British Columbia;Canada;career development;cell type;Cells;Chronic Disease;Collaborations;Communities;Comprehension;Dedications;design;Development;Discipline;Disease;disease phenotype;Disease susceptibility;diversity and inclusion;Educational workshop;Electronic Medical Records and Genomics Network;Emerging Technologies;Environment;Environmental Pollutants;Epigenetic Process;Faculty;Fostering;Future;Goals;Health;Human;Immune;Immune system;Immunologic Memory;immunoregulation;imprint;improved;Industry;Inflammaging;Inflammatory;innovative technologies;insight;interdisciplinary collaboration;International;Knowledge;Learning;Maintenance;Malignant Neoplasms;Mammals;Medical;meetings;member;Memory;Metabolic Diseases;Methodology;Methods;multidisciplinary;Natural Immunity;Neurodegenerative Disorders;Outcome;Participant;pathogen;Pathway interactions;posters;programs;Research;Research Personnel;response;Role;Science;Scientist;Senior Scientist;sound;stressor;symposium;synthetic biology;T cell differentiation;Talents;Technology;technology platform;Therapeutic;Tissues;tool;Training;transgenerational epigenetic inheritance;vaccine response;Work

PROJECT_TITLE: Innate Immune Memory: Mechanisms and Consequences


NIH_SPENDING_CATS: Genetics;Immunotherapy

PHR: PROJECT NARRATIVE The importance of the immune system in the fight against invading pathogens has long been recognized. However, recent developments in immunotherapy and personalized medicine have rekindled interest in identifying new, targeted treatments for patients afflicted with many diseases, such as cancer. Therefore, this Keystone Symposia conference provides a global forum for researchers to discuss leading discoveries and identify new mechanisms in RNA-mediated regulation of immune interactions that offer promise in identifying new immunological drug targets.

PROJECT_TERMS: Applied Research;Basic Science;Biological Products;Biology;Biotechnology;career;career development;Cells;Clinical;Collaborations;Colorado;Development;Discipline;Disease;Drug Targeting;Educational workshop;Elements;Environment;Epigenetic Process;epigenome;epitranscriptomics;experience;fighting;forging;frontier;Functional disorder;Gene Expression;Immune;Immune system;immune system function;Immunity;Immunologics;Immunologist;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;insight;Interdisciplinary Study;interest;interfacial;Invaded;Joints;Knowledge;Learning;Malignant Neoplasms;Mediating;meetings;Methodology;Molecular;Molecular Immunology;multidisciplinary;Nature;Outcome;pandemic disease;Participant;pathogen;Patients;personalized medicine;Pharmacologic Substance;Postdoctoral Fellow;posters;programs;Regulation;Research;Research Personnel;RNA;RNA Processing;Role;Scientist;sensor;Signal Pathway;Site;Students;symposium;System;Systems Development;Therapeutic;translational potential;Translational Research;Untranslated RNA;Virus Diseases

PROJECT_TITLE: RNA Mediated Regulation of Immunity: Mechanism, Disease and Therapeutics


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Glioblastoma Multiforme (GBM) is the most common and aggressive tumor in the brain. Among GBMs, those that are located near the brain lateral ventricles (LV) are the ones with the worst prognosis. Here, we will investigate the role of extracellular vesicles as communication mechanisms between brain tumors and the tumor microenvironment in the LV.

PI_NAMEs: GUERRERO-CAZARES, HUGO  (contact)

PROJECT_TERMS: Adult;Affect;Astrocytes;Binding;Biological Markers;Biotin;Brain;Brain Glioblastoma;Brain Neoplasms;brain parenchyma;cancer cell;Cell Differentiation process;Cells;Cerebral Dominance;Cerebrospinal Fluid;Characteristics;chemotherapy;Coculture Techniques;Combined Modality Therapy;Communication;Data;Diagnosis;Distal;Distant;Engineering;Excision;Expectancy;extracellular vesicles;Fostering;Glioblastoma;Glioma;Goals;Histologic;Homeostasis;Human;In Vitro;in vivo;Incidence;Infiltration;intercellular communication;Label;Lateral;lateral ventricle;Ligase;Lipids;Location;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;Membrane;Methods;Microglia;migration;Monitor;Morphology;nerve stem cell;neuroregulation;novel;Nucleic Acids;Operative Surgical Procedures;particle;Patient-Focused Outcomes;Patients;Phenotype;Plasma;Play;pluripotency;Population;potential biomarker;Primary Brain Neoplasms;Prognosis;Proliferating;Proteins;Protocols documentation;radiation effect;Radiation therapy;Recombinant Proteins;Recurrence;Recurrent tumor;release factor;Reporting;Research;Role;Sampling;self-renewal;senescence;Signal Transduction;standard of care;stem cell proliferation;subventricular zone;Survival Rate;System;temozolomide;Testing;Therapeutic;therapy resistant;transcriptome sequencing;transcriptomics;treatment response;tumor;Tumor Cell Invasion;tumor initiation;tumor microenvironment;Tumor Tissue;Undifferentiated;vesicular release;virtual;With laterality

PROJECT_TITLE: GLIOMA INTERACTION WITH THE NEUROGENIC NICHE THROUGH EXTRACELLULAR VESICLES


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Dissecting divergent hematopoietic stem and progenitor cell ontogeny during development Project Narrative Hematopoietic stem cells (HSC) and HSC-independent progenitors generate the diversity of the hematopoietic and immune landscape needed to sustain an organism from embryogenesis until death. The proposed research is relevant to public health because it will provide fundamental knowledge on the early establishment of hematopoietic and immune hierarchies deriving from HSC and HSC-independent progenitors, which is relevant to understanding immune disorders and for the directed production of HSC and HSC-independent progenitors and their functionally distinct progeny from pluripotent stem cell sources.

PI_NAMEs: BOWMAN, TERESA V (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: atheroprotective;Biological Assay;Blood;Cell Ontogeny;Cells;Cessation of life;Clinical;Complex;Coupled;Data;Defect;Development;Disease;Embryo;Embryonic Development;Environment;Excision;Gene Expression Profile;Generations;Genetic;Genetic Screening;Genetic Transcription;Growth;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;Hematopoietic Neoplasms;Hematopoietic stem cells;Hematopoietic System;hematopoietic transplantation;human pluripotent stem cell;Immune;Immune system;Immune System Diseases;immunodeficiency;In Situ Hybridization;in vivo;Indigenous;intravital imaging;Knowledge;life span;Lymphoid;Lymphoid Cell;Macrophage;Measures;Microglia;Modeling;Myelogenous;Myeloid Cells;Nerve Degeneration;Neurocognitive Deficit;Organism;Output;Patients;Pluripotent Stem Cells;Population;Positioning Attribute;Procedures;progenitor;programs;Property;Public Health;Regulation;Research;Role;self-renewal;single-cell RNA sequencing;Source;spatiotemporal;stem;stem cell function;stem cells;System;Testing;Time;Tissues;tool;Transplantation;Visualization;Work;Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-M (02)]


ORG_CITY: LA JOLLA

ORG_NAME: PROTEOGENOMICS RESEARCH INSTIT/SYS/ MED

PHR: Project Narrative/Public Health Relevance Statement Our proposed project is of obvious relevance to public health because it focuses on the discovery and development of safer and more effective lung disease therapies by exploiting a precision lung delivery mechanism that we discovered using an antibody that rapidly and actively traverses the endothelial cell barrier to penetrate lung tissue and linked it to anti-fibrotic biologics and small molecule. Using antibody genetic engineering and chemistry, we have created bispecific biologic prototypes, that are pumped first inside lung in minutes and then blocks a key therapeutic target deep inside diseased lung tissue, improving both precision targeting and therapeutic potency by >100-fold. We plan to expand preclinical testing and expect to exhibit therapeutic efficacy at very safe µg/kg doses, not the mg/kg doses customary for biologics.

PI_NAMEs: HAGOOD, JAMES S.;OLENYUK, BOGDAN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Antibodies;Binding;Biodistribution;Biological;Biological Products;biomarker validation;Bleomycin;Blood Circulation;Blood Vessels;Categories;Caveolae;Cell Surface Proteins;Cells;Chemicals;Chemistry;Cicatrix;Clinical;Clinical Trials;Deposition;design;Development;Diarrhea;Disease;Disease Progression;Dose;Drug Delivery Systems;efficacy testing;Endothelial Cells;Endothelium;Engineering;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;fibrotic lung;Foundations;Genetic Engineering;Goals;Human;idiopathic pulmonary fibrosis;Image;image processing;Imaging Techniques;Immunoconjugates;Immunotherapeutic agent;improved;In Vitro;in vitro activity;in vitro testing;in vivo;Inflammatory;interstitial;Interstitial Lung Diseases;intravenous injection;lead candidate;Length;Libraries;Link;liquid chromatography mass spectrometry;Liver Dysfunction;Lung;Lung Diseases;lung imaging;Magic;Measures;Mediating;Modeling;Morbidity - disease rate;mortality;mutant;Myofibroblast;nintedanib;novel;Oropharyngeal;Pathologic;Penetration;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Pirfenidone;precision drugs;Precision therapeutics;Preclinical Testing;prevent;Profibrotic signal;Proliferating;prototype;Public Health;public health relevance;Pulmonary Fibrosis;Pump;Rattus;restoration;Rodent Model;Role;scale up;side effect;Signal Pathway;single photon emission computed tomography;single-cell RNA sequencing;Site;Slice;small molecule;Societies;Structure of parenchyma of lung;targeted delivery;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;Time;tissue processing;Tissues;Toxic effect;transcytosis;Treatment Efficacy;Vascular Endothelium;Workplace;X-Ray Computed Tomography

PROJECT_TITLE: Localizing Therapeutics to Target Lung Myofibroblasts and Reverse Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

PHR: Cardiovascular disease is the leading cause of death among Veterans and congestive heart failure is among the most common conditions resulting in death, disability and hospitalization. With aging along with prevalent risk factors such as diabetes, COPD, obesity and hypertension, heart failure with a preserved ejection or, HFpEF, now equals the incidence of heart failure with a reduced ejection fraction or HFrEF. While we have made great advances in the drugs and devices available to treat HFrEF, they don’t work in HFpEF and diuretics remain the only therapy available to treat the increasing number of patients with this condition. The research proposed in this application will attempt to fill this critical gap in therapy by studying three therapies shown to reduce cardiac fibrosis in a preclinical model of HFpEF having many similarities to humans with this condition. A therapy that reverses cardiac interstitial fibrosis could improve filling of the left ventricle and have a major impact on symptoms, disability and survival of Veterans with this common condition.

PI_NAMEs: CANTY, JOHN M (contact)

PROJECT_TERMS: Address;Aging;Allogenic;Animal Disease Models;Animal Model;Apoptosis;Attenuated;Cardiac;cardiac aging;Cardiovascular Diseases;Caring;Cause of Death;Cell Therapy;Cells;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;comorbidity;Congestive Heart Failure;Coronary;coronary fibrosis;Development;Devices;Diabetes Mellitus;disability;Diuretics;EFRAC;Family suidae;Fibrosis;Functional disorder;Funding;Heart failure;Hospitalization;Human;Hypertension;hypertensive heart disease;Hypertrophy;Impairment;improved;Incidence;Induction of Apoptosis;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;interstitial;Intervention;Left;Left Ventricular Hypertrophy;Left Ventricular Remodeling;Left ventricular structure;Macrophage;Micelles;Microvascular Dysfunction;military veteran;Modeling;Muscle Cells;Myocardial;Myocardial Ischemia;novel;Obesity;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Pre-Clinical Model;preservation;pressure;Prevalence;prevent;Proliferating;Proline;recruit;Regulation;Research;response;Rest;Risk Factors;Rodent Model;Stretching;Symptoms;systolic hypertension;Testing;Translating;Troponin I;Ventricular;Veterans;Work

PROJECT_TITLE: Preventing and Reversing Interstitial Fibrosis in HFpEF


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE: RELEVANCE TO PUBLIC HEALTH Atherosclerosis is an occlusive disease that develops over many years as a result of lipid accumulation in major blood arteries. These atherosclerotic plaques contribute to the overall condition of coronary artery disease (CAD), which results in heart attack, stroke, and heart failure and is the leading cause of global mortality. Our proposal seeks to investigate the molecular processes by which protease-activated receptor 2 (PAR2) and the RNA binding protein human antigen R promotes cellular alterations and inflammation in atherosclerotic disease to advance new therapeutic targets and treatments for CAD.

PI_NAMEs: WADDING-LEE, CARIS ALYSSA (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Antigens;Arterial Fatty Streak;Arteries;Atherosclerosis;atherosclerotic plaque rupture;Attenuated;attenuation;autosome;Binding;Blood;Cardiovascular system;Cathepsins;Cause of Death;cell dedifferentiation;cell type;Cells;Cessation of life;Cholesterol;comorbidity;Complex;Coronary Arteriosclerosis;crosslink;cytokine;Cytosol;Data;Death Rate;Development;Diagnosis;diet and exercise;Disease;disease diagnosis;Disease Progression;Environment;exercise regimen;experimental study;Factor Xa;feeding;Female;G-Protein-Coupled Receptors;Genetic;Goals;Heart failure;Hematopoietic;Human;Immunoprecipitation;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;Injury;insight;Knock-out;Knowledge;Laboratories;Lipids;Literature;Low-Density Lipoproteins;LoxP-flanked allele;Macrophage;male;Mediating;Mediator;Messenger RNA;Molecular;Morbidity - disease rate;mortality;mouse model;mRNA Expression;mRNA Stability;Mus;mutant;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;PAR-2 Receptor;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;post-COVID-19;prevent;Process;protein expression;Proteins;Public Health;Publishing;receptor;RNA-Binding Proteins;Role;Site;Smooth Muscle Myocytes;Stains;Stimulation of Cell Proliferation;Stroke;targeted treatment;Techniques;Testing;Therapeutic;trend;Trypsin;United States;Up-Regulation;Vacuum;vascular contributions;Vascular Smooth Muscle;Vision;Western Blotting

PROJECT_TITLE: The role of PAR2 and HuR in programming atherosclerotic vascular smooth muscle cells


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE: Heart failure, and the preceding changes in myocyte size, contribute to the majority of deaths in the United States, yet current intervention strategies are insufficient to repair inflicted myocytes and instead function to postpone death. Past research has linked a number of tRNA mutations to cardiovascular disease, but the actual role of defects in tRNA expression and localization has not been investigated. This proposal will uncover changes in tRNA transcription, localization, and trafficking that occur during cardiac remodeling; and, ultimately aims to generate exciting new therapeutic possibilities for heart disease.

PI_NAMEs: PETROSINO, JENNIFER MORGAN (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Active Biological Transport;Adrenergic Agents;aorta constriction;Atrophic;Belief;Biological Assay;Biology;blood pressure elevation;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;CCRL2 gene;cell fixing;Cell Separation;Cell Size;Cells;Cessation of life;Chronic stress;Complex;Contractile Proteins;Cytoskeleton;Data;Defect;Dependence;Diffusion;excessive weight gain;Exercise;Functional disorder;functional improvement;Genetic Transcription;Growth;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Heart Rate;hemodynamics;Homeostasis;Human;Hypertrophy;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Injections;Intervention;Kinesin;Kinetics;knock-down;Label;Laboratories;Length;Link;Lower Organism;Malignant - descriptor;Mass Spectrum Analysis;Mediating;Messenger RNA;Microscopy;Microtubules;Modeling;Molecular;Motility;Motor;Muscle Cells;Mutation;new therapeutic target;Nocodazole;novel;novel therapeutics;Nuclear;Pathologic;pharmacologic;Phenylephrine;Physiological;Polymerase;pressure;Process;Property;Protein Biosynthesis;Proteins;Rattus;reconstitution;Regulation;repaired;Research;Resolution;response;RNA Transport;Role;single molecule;Site;spatiotemporal;Stains;Stimulus;Structure;superresolution microscopy;Surgical Models;Technology;Testing;Thick;tool;trafficking;Transfer RNA;Translations;Transport Process;United States;Untranslated RNA;Visualization;Work

PROJECT_TITLE: Microtubule-mediated tRNA localization in cardiac homeostasis and hypertrophy


ORG_CITY: NAPA

ORG_NAME: NEUROVATIONS

PHR: The HEAL R24 Coordinating Center for National Pain Scientists, known as Positively Uniting Researchers of Pain to Opine, Synthesize, and Engage (PURPOSE), is dedicated to collaborating with the recipients of HEAL Initiative Partnerships to Advance Interdisciplinary (PAIN) Training in Clinical Pain Research awards. Our objective is to establish a multifaceted, collaborative training initiative for postdoctoral clinical pain researchers across multiple sites. This educational experience and cohort development will be intricately woven into the existing online PURPOSE Network for pain researchers and supplemented by the annual in-person PURPOSE Annual Meeting. The PURPOSE initiative will closely cooperate with site Principal Investigators, mentors, trainees, evaluators, and established T32 programs to align and amplify training endeavors across the program. This approach will establish an integrated and supportive professional development network for the PAIN Cohort trainees, with the overarching goal of fostering their continued engagement and retention within the clinical pain research workforce.

PI_NAMEs: COVERSTONE, JACOB SUTTON (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Address;Award;clinical pain;cohort;Collaborations;Dedications;Development;Education;experience;Fostering;Goals;Helping to End Addiction Long-term;Institution;interdisciplinary collaboration;meetings;Mentors;Pain;Pain Research;Persons;Postdoctoral Fellow;Principal Investigator;programs;R24;Research Personnel;Science;Scientist;Site;Training

PROJECT_TITLE: PURPOSE: Positively Uniting Researchers of Pain to Opine, Synthesize, and Engage


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;HIV/AIDS;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Narrative Infants who are exposed to HIV but uninfected (iHEU) are at higher risk for neurodevelopmental delay compared to their HIV-unexposed counterparts, and have lower gut Bifidobacterium abundance and higher systemic inflammation during early life. Here, we propose to leverage an ongoing randomized, placebo- controlled, double-blind trial to assess whether Bifidobacterium infantis supplementation during the first month of life improves neurodevelopmental outcomes via decreases in systemic inflammation, and to in identify predictors of neurodevelopment in this population. Through the use of multiple data-driven approaches integrating biological measures with clinical neurodevelopmental outcomes, this study has the potential to inform novel intervention strategies or might ultimately lead to the development of diagnostics that help identify infants at risk of poor neurodevelopment.

PI_NAMEs: HAPPEL, ANNA-URSULA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Africa South of the Sahara;African;Age Months;Ancillary Study;Anti-Retroviral Agents;Antibiotic Prophylaxis;Antibiotics;antiretroviral therapy;Area;arm;Bacille Calmette-Guerin vaccination;bacterial community;Bifidobacterium;Biological;Biological Markers;Biometry;Brain;Breastfed infant;career development;Cell Ontogeny;Cells;Clinical;cognitive function;comorbidity;Computational Biology;cytokine;Data;Data Set;design;Development;Developmental Delay Disorders;diagnostic development;diagnostic tool;Disease;double-blind placebo controlled trial;Double-blind trial;early childhood;Enrollment;Epidemiology;Event;Exposure to;Feces;feeding;follow-up;Frequencies;Future;gut bacteria;gut microbiome;gut microbiota;Health;high risk;HIV;human data;Human Microbiome;Hylobates Genus;IL8 gene;Immune;immune activation;Immune response;Immunology;improved;Individual;infancy;Infant;infant morbidity;Inflammatory;Infrastructure;insight;interest;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention;Language;Lead;Life;life span;Measures;Mentors;Mentorship;metabolomics;Metagenomics;microbial;Microbiology;microbiome;microbiome composition;microbiota;microbiota composition;Milk;Molecular Biology;Motor Skills;National Institute of Mental Health;neurobehavioral;neurodevelopment;Neurologic;Neurotransmitters;novel;Oligosaccharides;Oral;Outcome;Parents;pediatric human immunodeficiency virus;perinatal HIV;Phenotype;Placebos;Plasma;Play;Population;postnatal;prenatal;prenatal exposure;Prevention;Randomized;Regimen;Reporting;repository;Research;Research Personnel;restoration;Risk;Role;Sampling;Secondary to;Shotguns;skills;South African;Supplementation;systemic inflammatory response;T-Lymphocyte;Testing;TNF gene;Toddler;tool development;Training;transmission process;United States National Institutes of Health;Universities;virology

PROJECT_TITLE: Bifidobacterium infantis supplementation in early life to improve neurodevelopment in infants exposed to HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: KAMPALA

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: Project Narrative Neurocognitive disability following HIV-associated cryptococcal meningitis is common, but little is known about the risk factors associated with poor neurocognitive outcomes, and it is unclear if resulting deficits are reversible in the long-term. This project seeks to better describe the prevalence, magnitude, and risk factors for persistent neurologic deficits after cryptococcal meningitis. This project will result in a better understanding of the role of persistent markers of infection, chronic inflammation, and neurocognitive disability.

PI_NAMEs: NSANGI, LAURA JOAN (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Activities of Daily Living;Acute;Adult;Africa;Age;Antigens;Biological Markers;C-reactive protein;Cause of Death;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cerebrospinal Fluid;Cessation of life;Chronic;Clinical;Clinical Research;Clinical Trials;cognitive function;cohort;Consent;Cryopreservation;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;cytokine;Data;Diagnosis;disability;Education;Enrollment;experience;Focal Neurologic Deficits;follow-up;Foundations;Future;Goals;Growth;HIV;HIV Seronegativity;Hyponatremia;IL17 gene;Immune response;Immune System Diseases;Immunologic Markers;Immunologics;Impairment;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory;Interferons;Interleukin-1 beta;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-6;Intervention;Intracranial Hypertension;Investigation;Longitudinal cohort;Meningitis;mortality;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;neurocognitive test;neuroimmunology;Neurologic;Neurologic Deficit;novel;Outcome;Outcome Assessment;Participant;Performance;Persons;Pleocytosis;Policies;Population;Prevalence;Prognostic Factor;Prospective cohort;recruit;Research;restoration;Risk Factors;Role;Sampling;screening;Seizures;Serum;Site;Specimen;success;Survivors;Testing;TNF gene;Translational Research;Uganda;United States National Institutes of Health

PROJECT_TITLE: Late Neurological Sequelae after Cryptococcal Meningitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: Durban

ORG_NAME: KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV

PHR: PROJECT NARRATIVE High obesity rates increasingly contribute to cardiometabolic disease risk in people with HIV. This project addresses this public health issue by assessing physical activity patterns and developing a physical activity intervention to reduce cardiometabolic risks in obese individuals with HIV. If successful, this project is expected to lead to a novel intervention that could benefit people living with HIV and obesity in rural settings in South Africa and beyond.

PI_NAMEs: MABWEAZARA, SMART  (contact)

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adult;adult obesity;antiretroviral therapy;Anxiety;Area;behavior change wheel;Behavior Therapy;Blood Pressure;blood pressure control;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;career;Characteristics;Cholesterol;Clinical Trials;co-infection;comorbidity;cost;Data;Data Science;Depression screen;Development;Diabetes Mellitus;Disease Marker;Disease Outcome;disorder risk;Doctor of Philosophy;Energy Metabolism;Epidemiology;Evaluation;Exercise;exercise intervention;Exercise Physiology;experience;Expert Opinion;Focus Groups;follow-up;Funding;Glean;Glycosylated hemoglobin A;Goals;Government;Health;Health Expenditures;Hip region structure;HIV;Hypertension;improved;indexing;interest;Intervention;Learning Skill;Measures;medical complication;men;Mental Depression;Mental Health;Mentors;Mentorship;Metabolic;Methods;mindfulness;Modernization;Modification;mortality;novel;obese person;Obesity;obesity risk;Office Nursing;Outcome;Participant;Patient Self-Report;Pattern;Persons;Physical activity;Physical assessment;pilot test;Postdoctoral Fellow;preference;prevent;primary outcome;Public Health;Publications;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Research;research clinical testing;Research Design;Research Priority;Research Support;Resource-limited setting;Risk;Risk Factors;Risk Reduction;Rural;rural setting;rural South Africa;Safety;Science;secondary outcome;sedentary lifestyle;South Africa;South African;standard of care;systematic review;Target Populations;Testing;therapy development;Time;Training;treatment guidelines;United States National Institutes of Health;Universities;waist circumference;wearable device;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: Development and evaluation of a physical activity intervention for obese people with HIV in rural South Africa.