NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: WOODS & POOLE ECONOMICS I

PHR: These specifically-developed estimates will be used to produce cancer statistics and to monitor cancer trends over time by county and census tract characteristics such as age, gender, race, as well as by other population socioeconomic characteristics.  In addition to meeting crucial NCI data needs, these estimates will enable NCI scientists to better assess sociodemographic patterns and disparities in cancer rates.

PI_NAMEs: HOLDRICH, MARTIN  (contact)

PROJECT_TERMS: Age;age group;Age Years;Black race;Calendar;cancer health disparity;cancer statistics;Cancer Surveillance Research Program;Censuses;Characteristics;Contracts;County;Data;Gender;Geography;Hispanic;Malignant Neoplasms;meetings;Monitor;Pattern;Population;Race;Reporting;Scientist;Signal Recognition Particle;sociodemographics;socioeconomics;Time trend

PROJECT_TITLE: ANNUAL POPULATION ESTIMATES FOR COUNTIES AND CENSUS TRACTS BASED ON THE COUNTS PRODUCED BY THE US CENSUS BUREAU.  THESE SPECIFI


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: FREDERICK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TERMS: Bacterial Artificial Chromosomes;Communities;data hub;data modeling;Development;Division of Cancer Control and Population Sciences;Future;Leadership;Maintenance;Population Sciences;Security;System;Update

PROJECT_TITLE: DCCPS - BACS: Population Sciences


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SAN DIEGO

ORG_NAME: AVANTGEN, INC.

ORG_STATE: CA

PI_NAMEs: FAN, XIAOMIN  (contact)

PROJECT_TERMS: Affinity;Antibodies;Antigen Targeting;Antigens;B-Lymphocytes;Biological Assay;Biological Markers;Cells;Chiroptera;cytokine;Cytokine Receptors;design;Development;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;gene synthesis;Immune response;Immunize;Immunologic Markers;Libraries;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;novel;Oryctolagus cuniculus;Phase;Production;protein purification;Reagent;receptor;Research Personnel;Research Priority;Sampling;Specificity;Splenocyte;Tertiary Protein Structure;Testing;Virus Diseases;Yeasts

PROJECT_TITLE: DEVELOPMENT OF RABBITMONOCLONAL ANTIBODIES FOR INDIANFLYING FOX (BAT) BIOMARKERS


ADMINISTERING_IC: OD

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Agreement;Area;authority;Categories;Childhood;Clinic;Collaborations;Communicable Diseases;Consent Forms;Data Collection;Data Management Resources;design;Development;Extramural Activities;feeding;Funding;Funding Opportunities;HIV;Infant;Institutional Review Boards;instrument;International;maternal outcome;meetings;Mission;Mothers;National Institute of Child Health and Human Development;NIH Office of AIDS Research;Outcome;Outcome Study;Parents;Peer Review;Persons;preference;prevent;Procedures;programs;Protocols documentation;Publishing;Research;Research Personnel;research study;Research Support;Site Visit;U-Series Cooperative Agreements;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: UNDERSTANDING INFANT FEEDING PREFERENCES, PRACTICES, AND OUTCOMES FOR MOTHERS AND OTHER PARENTS WITH HIV IN THE UNITED STATES CDC RFA 24 040 AOD240230014951


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MC LEAN

ORG_NAME: BOOZ ALLEN HAMILTON

ORG_STATE: VA

PI_NAMEs: KELLER, MICHAEL  (contact)

PROJECT_TERMS: Award;biobank;Development;Helping to End Addiction Long-term;improved;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: FY24 AWARD. NIDA DEVELOPMENTAL STUDIES BIOREPOSITORY AND ANALYSIS CENTER. SEPTEMBER 17, 2024 - SEPTEMBER 16, 2025. N01DA-21-5588. TASK ORDER 75N95024F00001 (TO4).


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PI_NAMEs: SCHEINFELDT, LAURA  (contact)

PROJECT_TERMS: Biological;Contracts;Data;genetic resource;Genotype;Human Genetics;human subject;National Institute of Neurological Disorders and Stroke;Phenotype;Process;Sampling

PROJECT_TITLE: CORIELL - NINDS HUMAN GENETICS RESOURCE CENTER


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: CLIFTON

PI_NAMEs: MISHRA, SOMNATH  (contact)

PROJECT_TERMS: Biological Products;National Institute of Neurological Disorders and Stroke;Process;product development;Services

PROJECT_TITLE: BIOLOGICS SME CONSULTING SERVICES


ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: JELSTROM, EVE  (contact)

PROJECT_TERMS: Buprenorphine;Dose;Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: CCC TO 11 - CTN-0145: STANDARD VERSUS HIGH DOSE ED-INITIATED BUPRENORPHINE INDUCTION. POP: 8/28/23 - 8/27/27.


ORG_CITY: ALEXANDRIA

PI_NAMEs: GRACE, MICHAEL  (contact)


ORG_CITY: WALNUT CREEK

PI_NAMEs: BALL, OLIVER  (contact)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE MEMORIAL INSTITU

ORG_STATE: OH

PI_NAMEs: SPARROW, BARNEY  (contact)

PROJECT_TERMS: Age;Animals;Biological Assay;carcinogenesis;carcinogenicity;Carcinogens;Chronic Disease;Clonal Expansion;Databases;Development;driver mutation;Environmental Exposure;Environmental Hazards;Future;Genes;hazard;Histologic;Human;In Vitro;Malignant Neoplasms;molecular diagnostics;Mutation;neoplastic;normal aging;novel;novel strategies;Pathogenicity;Process;programs;Rodent;Rodent Model;Sampling;screening panel;Screening procedure;Technology;Testing;Time;Tissues;Transcript;transcriptomics

PROJECT_TITLE: Development of a cancer driver mutation screening panel to predict carcinogenesis using error corrected duplex sequencing technology


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Nutrition;Pediatric;Prevention;Women's Health Research

PI_NAMEs: ANAND, RAVINDER  (contact)

PROJECT_TERMS: Age;Amoxicillin;Anxiety;Azithromycin;Bacterial Infections;Best Pharmaceuticals for Children Act;Blood;Breast Feeding;Breastfed infant;Buprenorphine;Bupropion;Child;Childhood;chronic pain;Clindamycin;Clinical Research;clinical research site;Contracts;Data;Data Coordinating Center;data sharing;Data Storage and Retrieval;design;Diabetes Mellitus;Dose;Drug Kinetics;Drug usage;duloxetine;Enrollment;follow-up;Fright;Human Milk;Hydrocodone;Hypertension;Infant;Labetalol;Lactation;Levetiracetam;Medical;medication safety;Mental Depression;Metformin;Mothers;Nifedipine;off-patent;Ondansetron;Oxycodone;Paroxetine;participant enrollment;Pharmaceutical Preparations;preclinical study;Regulation;Research Personnel;Role;Safety;safety assessment;Sampling;Sertraline;Statistical Data Interpretation;Symptoms;Time;Tranexamic Acid;Woman

PROJECT_TITLE: DATA COORDINATING CENTER FOR THE BEST PHARMACEUTICALS FOR CHILDREN ACT(BPCA) - PTN CUDDLE


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Project Narrative The proposed research is relevant to public health because it seeks to create a research network to expand our understanding of how music-based interventions (MBIs) work to alleviate pain. The research network, comprised of a cross disciplinary team comprised music therapists, engineers, psychologists, social workers, and basic scientists, will also explore new, interesting ways to measure pain during music experiences. Thus, the proposed research is relevant to the part of the NIH’s mission to understanding and optimizing the use of MBIs to improve health.

PI_NAMEs: BURNS, DEBRA S (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TITLE: Music mechanisms and technologies network: Integrative models to address pain through music


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Social Determinants of Health

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PI_NAMEs: MOSLEY, THOMAS  (contact)

PROJECT_TERMS: Adult;African American;aged;Amyloid deposition;Ancillary Study;Area;arterial stiffness;Atherosclerosis;Atherosclerosis Risk in Communities;Atrial Fibrillation;Biochemical;Biological Assay;Biological Specimen Banks;Blood specimen;Blood Vessels;Brain;Candidate Disease Gene;Cardiovascular Diseases;Case/Control Studies;caucasian American;Clinical;clinical development;clinical examination;Cognition;cohort;Cohort Studies;Communities;Consent Forms;Contractor;Contracts;coronary artery calcification;Coronary heart disease;County;Cryopreservation;Data;Death Rate;Dementia;Diabetes Mellitus;DNA;EFRAC;Electrocardiogram;Environmental Risk Factor;Event;follow-up;Funding;Funding Agency;Genetic;Genome Scan;Geographic Locations;Grant;Heart failure;Hospitalization;Injury;Investigation;Lymphocyte;member;middle age;Monitor;Myocardial Infarction;Natural History;novel;Participant;Preparation;preservation;Procedures;Prospective, cohort study;Publications;quality assurance;Quality Control;Recommendation;recruit;Research Personnel;residence;Risk Factors;rural setting;Standardization;suburb;Technology;trend;United States National Institutes of Health;Ventricular Dysfunction;Visit;Vital Status;Washington;Work

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK AREA B


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: SELVIN, ELIZABETH  (contact)


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: LUTSEY, PAMELA  (contact)

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY FIELD CENTER - TASK AREA B


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PI_NAMEs: WAGENKNECHT, LYNNE  (contact)


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: COUPER, DAVID  (contact)

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CHELMSFORD

ORG_NAME: TRITON SYSTEMS, INC.

ORG_STATE: MA

PI_NAMEs: TAKEDA, TAKAKO  (contact)

PROJECT_TERMS: Age;Algorithms;Biological Assay;Biopsy;Blood specimen;Blood Tests;Classification;classification algorithm;cost;detection test;Development;Devices;Diagnostic Reagent Kits;Family;Fingers;Formulation;Geography;high risk population;Home;home test;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Modeling;Monitor;mortality;Paper;Patients;Phase;point of care;point-of-care detection;Price;prostate cancer risk;Prostate specific antigen measurement;Prostate-Specific Antigen;prototype;PSA screening;Race;Reagent;Recording of previous events;Risk;Risk Factors;Screening for Prostate Cancer;Techniques;Technology;Triton

PROJECT_TITLE: TOPIC 455: A LOW COST, POINT-OF-CARE DETECTION DEVICE FOR PROSTATE SPECIFIC ANTIGEN USING A PAPER-BASED FLOW ASSAY


ORG_CITY: TORRANCE

ORG_NAME: INTELLIGENT OPTICAL SYSTEMS, INC.

PI_NAMEs: NGUYEN, TRONG  (contact)

PROJECT_TERMS: Address;Adopted;Biological Assay;Blood Tests;Clinical;combat;cost;cost effective;Counseling;Data;detection limit;Devices;Early Intervention;empowerment;FDA approved;Goals;Health;Home;innovation;lateral flow assay;male;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;men;Monitor;mortality;Phase;point of care;point-of-care detection;Prostate-Specific Antigen;prototype;PSA level;PSA screening;Reader;Regulatory Pathway;Sampling;self testing;Serum;smartphone application;Specificity;test strip;Testing;Validation;Whole Blood

PROJECT_TITLE: TOPIC 455: FINGERSTICK BLOOD TEST FOR POINT-OF-CARE DETECTION OF PROSTATE SPECIFIC ANTIGEN


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: BOSTON CELL STANDARDS INC

PI_NAMEs: BOGEN, STEVE  (contact)

PROJECT_TERMS: accurate diagnosis;Address;Astronomy;Biopsy;Boston;Cancer Patient;Cells;Certification;Clinical;comparative;Computer software;Contracts;Data;Databases;Development;editorial;Image;Immunohistochemistry;improved;Instruction;Laboratories;Laboratory Research;Malignant Neoplasms;manufacture;Measures;Output;Performance;Phase;programs;Reference Standards;response;Small Business Innovation Research Grant;Stains;Testing;tissue biomarkers;Unit of Measure;whole slide imaging

PROJECT_TITLE: FY24 SBIR PHASE II RD CONTRACT - TOPIC 442 BOSTON CELL STANDARDS, INC.


ORG_CITY: Seattle

ORG_NAME: INBIOS INTERNATIONAL, INC.

ORG_STATE: WA

PI_NAMEs: RATCHAUDHURI, SYAMAL  (contact)

PROJECT_TERMS: African American;antigen detection;Biological Assay;Blood;Blood specimen;Communicable Diseases;Death Rate;Detection;Development;Diagnostic Reagent Kits;Early Diagnosis;FDA approved;Fingers;Future;Goals;Home;home test;Immunoassay;Incidence;instrument;Lateral;Malignant neoplasm of prostate;Medical;men;Performance;Phase;Populations at Risk;Prospective Studies;prostate cancer risk;Prostate-Specific Antigen;prototype;PSA level;PSA screening;rapid test;reagent testing;research clinical testing;self testing;Small Business Innovation Research Grant;Technology;Testing

PROJECT_TITLE: TOPIC 455: DEVELOPMENT OF A RAPID AT-HOME TEST TO DETECT PROSTATE-SPECIFIC ANTIGEN USING SELF-COLLECTED FINGER STICKBLOOD


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: ELECTRONIC BIOSCIENCES, INC.

PI_NAMEs: ERVIN, ERIC  (contact)

PROJECT_TERMS: Blood;Body Regions;Calibration;cancer diagnosis;Cancer Etiology;Cessation of life;comparative;cost;design;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Early Diagnosis;effective therapy;Evaluation;Healthcare;high risk men;Home;home test;improved;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methodology;Patients;performance tests;Phase;Play;point of care;Price;Prognosis;programs;Prostate;Prostate-Specific Antigen;prototype;Provider;PSA level;PSA screening;Risk;screening;Small Business Innovation Research Grant;Structure of base of prostate;Surveys;Survival Rate;Technology;Testing;usability

PROJECT_TITLE: TOPIC 455: IDEAL AT-HOME PROSTATE SPECIFIC ANTIGEN (PSA) TESTING


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases;Women's Health Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TERMS: Affect;Biological;cancer genetics;Cancer Intervention;cancer risk;case control;Case/Control Studies;cohort;Collaborations;Complex;Data;data access;Data Set;deep sequencing;Diagnostic;Disease;disorder risk;Division of Cancer Epidemiology and Genetics;DNA;Ensure;epidemiology study;Extramural Activities;gene environment interaction;Genes;Genetic Markers;Genetic Predisposition to Disease;genetic variant;Genome Scan;genome wide association study;Genomics;Individual;Inherited;large datasets;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Persons;Phenotype;Pilot Projects;Population Study;Predisposition;Preventive;Private Sector;programs;Research;Research Personnel;Resources;Risk;Scanning;Scientist;Series;Techniques;Therapeutic Intervention;trait;United States National Institutes of Health;Variant

PROJECT_TITLE: DCEG- GWAS Studies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Infectious Diseases;Prevention

PROJECT_TERMS: Affect;alpha Tocopherol;American Cancer Society;anti-cancer research;Area;Basic Science;Beta Carotene;bioinformatics pipeline;Biological Assay;Cancer Burden;cancer genomics;cancer prevention;Cervical Cancer Screening;clinically relevant;cohort;Colon;cost;Custom;Data;data access;Data Analyses;Data Storage and Retrieval;database of Genotypes and Phenotypes;design;Development;digital;digital pathology;Disease;Disease Outcome;Division of Cancer Epidemiology and Genetics;DNA;Electronics;Employment;Environmental Risk Factor;Epidemiologist;epidemiology study;exome;exome sequencing;Experimental Designs;Family;follow-up;Generations;Genes;Genetic;genetic epidemiology;Genetic Markers;genetic variant;Genetic Variation;Genome Scan;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Heritability;Human Genome;human genomics;Human Papillomavirus;Image;Immunohistochemistry;Individual;Informatics;Information Management;interest;Intramural Research Program;Laboratories;Laboratory Research;Lung;Malignant Neoplasms;Meta-Analysis;Molecular Epidemiology;molecular pathology;Mutation;Normal tissue morphology;novel;Nucleic Acids;Outcome;Ovarian;Phenotype;Population;Population Group;Predisposition;Prostate;Publishing;rare variant;Research;Research Support;Resources;response;Sampling;Scanning;Scientist;screening;Specimen;Statistical Methods;Support Groups;Surveys;Techniques;Technology;tissue processing;Tissues;tumor;Work

PROJECT_TITLE: DCEG- Genotyping for epidemiology studies


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS

PROJECT_TERMS: Biological;cold temperature;Collection;computerized;Contracts;Development;Division of Cancer Epidemiology and Genetics;Epidemiology;epidemiology study;Equipment;Equipment and supply inventories;Human;Maintenance;Molecular Epidemiology;preservation;Procedures;programs;repository;Sampling;Services;Specimen;Transportation

PROJECT_TITLE: DCEG- Repository Services for epidemiology studies


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics

PROJECT_TERMS: anti-cancer research;biobank;Biological;Biological Assay;Biological Process;bioprocess;blood fractionation;Blood specimen;cancer epidemiology;cell immortalization;Cell Line;Cells;Cervical;CLIA certified;Clinical;cold temperature;Contracts;Cryopreservation;Cryopreserved Cell;Cytology;Detection;Diagnostics Research;Division of Cancer Epidemiology and Genetics;DNA;Electronics;Epidemiology;epidemiology study;Erythrocytes;established cell line;Feces;Fibroblasts;Flow Cytometry;Fluorescence-Activated Cell Sorting;Freeze Drying;Freezing;Hormones;Human;Human Herpesvirus 4;Immunologic Monitoring;Immunologic Tests;Immunologics;In Vitro;Infrastructure;instrumentation;Laboratories;Liquid substance;Malignant neoplasm of cervix uteri;Mass Spectrum Analysis;Measurement;Molecular;molecular diagnostics;Molecular Epidemiology;Mutation Detection;Nitrogen;Nucleic Acids;Paraffin Embedding;Pathogen detection;Pathogenesis;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Polymorphism Analysis;Preparation;Prevention;Process;programs;Proteins;quality assurance;Quality Control;Reporting;repository;Research Personnel;RNA;Scientist;Serum;Services;Single Nucleotide Polymorphism;small molecule;Specimen;Specimen Handling;Spectrophotometry;Structure;Techniques;Technology;Tissue Embedding;Tissues;transforming virus;tumor;Urine;Virus;Whole Blood

PROJECT_TITLE: DCEG- Molecular Assays for epidemiology studies


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Natural Products;Precision Medicine

PROJECT_TERMS: Antineoplastic Agents;assay development;biobank;Biological;Biological Assay;Biological Markers;Biological Products;biopharmaceutical industry;Clinic;Clinical;clinical center;Clinical Trials;Collaborations;Contracts;Correlative Study;Cyclic GMP;Data Science;Development;Diagnostic;Diagnostic tests;Discipline of Nursing;Division of Cancer Treatment and Diagnosis;drug development;drug discovery;Drug Kinetics;drug production;Evaluation;Funding;Genomics;high throughput screening;Image;In Vitro;in vivo;Informatics;Information Systems;Laboratories;Libraries;Malignant Neoplasms;manufacture;Medical;Molecular;Nanotechnology;Natural Products;New Agents;novel diagnostics;novel therapeutic intervention;patient derived xenograft model;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacology;Pre-Clinical Model;Precision medicine trial;Production;programs;Radiochemistry;Radiopharmaceuticals;repository;Research;Services;Technology;Testing;Therapeutic Intervention;Toxicology;Translational Research;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Division of Cancer Treatment and Diagnosis- Operational Task Order


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PROJECT_TERMS: Antibodies;Benign;Calibration;Capsid Proteins;Cells;Cervarix;Communities;Development;Dose;Evaluation;Gardasil;Genotype;Goals;high risk;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Human papillomavirus HPV L1 protein;Insecta;Laboratories;Licensing;Malignant neoplasm of cervix uteri;Oncogenic;Qualifying;Reagent;Recombinants;Regimen;Resources;Serology;Serology test;Serum;Standardization;Testing;vaccine development;vaccine-induced immunity;Vaccines;virtual;Virus-like particle;Work;Yeasts

PROJECT_TITLE: HPV Serology


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute Promyelocytic Leukemia;Agonist;Anaphase;Aneuploidy;antagonist;Antineoplastic Agents;Biological Assay;Chimeric Proteins;combat;companion diagnostics;Differentiation Therapy;Etiology;FDA approved;Genetic;Immunotherapy;Laboratories;Malignant Neoplasms;Molecular;Normal Cell;Pathway interactions;Pharmacology;Play;Retinoic Acid Receptor;retinoic acid receptor alpha;Retinoids;RXR;Signal Transduction;targeted cancer therapy;tool;ubiquitin isopeptidase

PROJECT_TITLE: Molecular Pharmacology Lab


NIH_SPENDING_CATS: Cancer;Clinical Research

PROJECT_TITLE: Strategic Scientific Pilot Support


PROJECT_TERMS: Address;anti-cancer research;Cryoelectron Microscopy;Data Collection;Goals;Image;interest;Laboratories;Macromolecular Complexes;Malignant Neoplasms;Microscope;National Cancer Institute;Resolution;Structural Biologist;United States National Institutes of Health

PROJECT_TITLE: Cryo-EM


PROJECT_TERMS: anti-cancer research;Capital;Core Facility;Development;Equipment;Expenditure;Funding;Gene Mutation;Institution;Intramural Research Program;Laboratories;Laboratory Research;Malignant Neoplasms;Modeling;programs;RAS genes;Research;research and development;Research Personnel;Signal Transduction;Technology;Therapeutic;United States Dept. of Health and Human Services

PROJECT_TITLE: RAS Program at FNL


PROJECT_TERMS: base;Clinical;clinical center;Computers;Contractor;Contracts;Development;Funding;improved;Libraries;Maryland;National Cancer Institute;Office of Administrative Management;operation;programs;repaired;research and development;Research Personnel;Services;statistical service;United States National Institutes of Health

PROJECT_TITLE: NCI-F Operations and Technical Support II


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research

PROJECT_TITLE: Informatics Support at FNLCR


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PI_NAMEs: LYNCH, DAVID  (contact)

PROJECT_TERMS: Adult;Affect;African American;Age;Air;built environment;cardiovascular risk factor;Characteristics;Chicago;Coronary Artery Risk Development in Young Adults Study;Crime;Data;Discrimination;Drowsiness;Economics;Ensure;Environment;ethnic minority;Ethnic Origin;experience;Exposure to;Gender;Goals;Individual;Institutional Racism;Link;Mentors;Neighborhoods;Noise;parent grant;poor sleep;psychological distress;psychosocial;Race;racial minority;Racial Segregation;Reporting;residential segregation;Sleep;sleep behavior;sleep health;sleep quality;sociodemographic factors;Training;Trauma;United States

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - CHICAGO FIELD CENTERDIVERSITY SUPPLEMENT FOR MORGANN WEST


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: anti-cancer research;cancer genomics;Clinical Data;Collection;Communities;data repository;Data Set;data sharing;effective therapy;follow-up;Genomic approach;Genomic Data Commons;Malignant Childhood Neoplasm;Molecular;precision medicine;Research;Therapeutic;treatment program;Update

PROJECT_TITLE: GDC Clinical Data Update


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

PROJECT_TERMS: Blood;Breast Cancer Prevention Trial;Clinical Trials;cost;Leukocytes;Maintenance;National Surgical Adjuvant Breast and Bowel Project;Plasma;repository;Specimen;Study of Tamoxifen and Raloxifene;Woman;Women's study

PROJECT_TITLE: DCP - COPTRG Support [National Surgical Adjuvant Breast and Bowel Project (NSABP)


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

PROJECT_TERMS: biomarker validation;Clinical;Clinical Research;Early Detection Research Network;Funding;Histologic;interest;Prevention;repository;Screening for cancer;Specimen;Tissues;Vial device

PROJECT_TITLE: DCP - Early Detection Research Network (EDRN) Repository


PROJECT_TERMS: Area;clinical development;Contractor;Development;Development Plans;human biological material;Knowledge;Laboratories;manufacturing capabilities;Marketing;Monitor;operation;Performance;Phase;pre-clinical;Procedures;Process;product development;programs;Protocols documentation;public-private partnership;quality assurance;Quality Control;research clinical testing;Site;skills;Specimen;Therapeutic;Vaccines

PROJECT_TITLE: DCP - COPTRG - SELECT/PCPT


PROJECT_TITLE: DCP- Cancer Immunoprevention Laboratory Support


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

PROJECT_TERMS: biobank;Biological Specimen Banks;cancer prevention;clinical research site;Contracts;Phase;prevention clinical trial;programs

PROJECT_TITLE: DCP - Cancer Prevention Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia) BioRepository


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science

PROJECT_TITLE: DCP - Clin Trl Info Mgt -DCP Enterprise System Knowledge Base (DESK)


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: base;Clinical;clinical center;Computers;Contract Services;Contractor;Contracts;data management;Development;Funding;improved;Information Services;International;Libraries;Maryland;National Cancer Institute;Office of Administrative Management;operation;programs;repaired;Research Personnel;Science;Services;statistical service;Support Contracts;United States National Institutes of Health

PROJECT_TITLE: NCI-Frederick Operational Support


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Antibody Response;Automobile Driving;COVID-19;COVID-19 pandemic;COVID-19 test;Diagnosis;Disease;Goals;Immune response;Laboratories;Light;Methods;Molecular;novel coronavirus;pathogen;Procedures;Public Health;Reagent;Research;response;Science;Serology;Serology test;Standardization;Testing

PROJECT_TITLE: Serological Science for COVID-19 SeroNet


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Area;Biological Products;Cell Culture Techniques;Cell Therapy;Clinical;Clinical Trials;Contractor;Development;Good Manufacturing Process;Guidelines;Immunoconjugates;Industry;Investigational Drugs;manufacture;Mission;Monoclonal Antibodies;Peptides;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase III Clinical Trials;plasmid DNA;Program Development;Recombinant Proteins;Regulation;Research Personnel;Sterility;Testing;United States Food and Drug Administration;vector vaccine;Vial device;Virus;Work

PROJECT_TITLE: DCP - Biopharmaceutical Development Program (BDP) Support


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

PROJECT_TERMS: Area;Caribbean region;clinical development;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Contractor;Contracts;Development;Development Plans;experience;HIV;human biological material;Human Papilloma Virus-Related Malignant Neoplasm;Knowledge;Laboratories;Latin American;manufacturing capabilities;Marketing;Monitor;Nursing Research;operation;Performance;Phase;pre-clinical;prevention clinical trial;Procedures;Process;product development;programs;Protocols documentation;public-private partnership;quality assurance;Quality Control;Regulatory Affairs;research clinical testing;Site;skills;Specialist;Specimen;Therapeutic;Vaccines

PROJECT_TITLE: DCP - Clinical Trials Regulatory & Monitoring Support for US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network


PROJECT_TERMS: Advocate;American;anti-cancer research;Cancer Control;Congresses;Contractor;Country;Data;Data Analyses;Documentation;experience;global health;Grant;Individual;international partnership;Knowledge;Leadership;low and middle-income countries;meetings;Mission;Oncology;Play;Publications;Reporting;Research;Scientist;Site;technical writing;Training;Training Activity;Travel;web site;Work;Writing

PROJECT_TITLE: CGH - Center for Global Health Data Analysis, Technical Support and Dialogues


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: GREENVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Narrative Inhalation of the bacterium Yersinia pestis results in pneumonic plague, a highly lethal infection with mortality rates approaching 100%. The proposed work seeks to understand the interaction of Y. pestis with host cells in the lung by characterizing the function of a well-established mediator of pathogenesis in the early events that establish pneumonic plague.

PI_NAMEs: HUANG, LU ;PECHOUS, ROGER D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adherence;Alveolar Macrophages;Attenuated;Bacteria;Bacterial Adhesins;bacterial resistance;cell type;Cells;Data;Death Rate;Disease;Epithelial Cells;Event;Feedback;Flow Cytometry;Fluorescence-Activated Cell Sorting;Growth;Human;Immune;Immune signaling;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Inhalation;innate immune mechanisms;Innate Immune Response;insight;Laboratories;Lung;Lung infections;Maps;Mediating;Mediator;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;pathogen;Pathogenesis;Peptide Hydrolases;Phase;Phosphotransferases;Plague;Plasminogen Activator;Play;Pneumonic Plague;Population;Population Dynamics;prevent;Proteome;Proteomics;Reporter;Research;response;Role;sensor;Surface;Surveys;Symptoms;System;Testing;Time;Tissues;transcriptomics;Virulence Factors;Work;Yersinia;Yersinia pestis

PROJECT_TITLE: Defining the Role of the Plasminogen Activator Protease in the Early Events that Establish Primary Pneumonic Plague

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: BALNE, PRAVEEN K (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Affect;Age;age acceleration;age effect;aged;Aging;aging related;Autophagocytosis;Blindness;Blood Glucose;Cell Aging;Chronic;Confocal Microscopy;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;Diabetes Mellitus;diabetic;diabetic patient;Disease;epithelial injury;Esthesia;experimental study;Exposure to;Eye;Flow Cytometry;FRAP1 gene;Gene Expression;Glucose;Health Expenditures;Human;Hyperglycemia;Immersion;Immunohistochemistry;Incidence;Infection;Inflammation;Injury;insight;Keratopathy;Length;Mass Spectrum Analysis;Metabolism;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;novel;Organ;pandemic disease;Pharmaceutical Preparations;Phase;Physiological;Play;Predisposition;Prevalence;prevent;protein expression;Public Health;Quantitative Reverse Transcriptase PCR;Research Proposals;response;Role;Severities;Signal Transduction;Therapeutic;Time;transcriptome sequencing;Western Blotting;Zebrafish

PROJECT_TITLE: Diabetic Keratopathy and Aging


PI_NAMEs: ENDICOTT, SAMUEL JOSEPH  (contact)

PROJECT_TERMS: age-related disease;Alzheimer's Disease;Atherosclerosis;Autophagocytosis;Biological Assay;Biosensor;Cancer Center;Cell Culture Techniques;Cells;Clathrin;Clathrin Adaptors;Complex;Consensus;Cytoplasm;Data;Disease;Drug Side Effects;Dynamin;Endocytic Vesicle;Endocytosis;Endosomes;enhancer-binding protein AP-2;Equipment;Fatty Acids;fatty liver disease;Future;Glycolysis;Goals;Growth Factor;Growth Factor Receptors;Individual;Inflammation;inhibitor;insight;Insulin;Insulin Receptor;insulin receptor tyrosine kinase;insulin signaling;intervention refinement;Ligand Binding;Ligands;Lysosomes;Malignant Neoplasms;MAP4;Mediating;Membrane;Metabolism;Microscope;Microscopy;Microtubules;Molecular Chaperones;Mus;new therapeutic target;novel;Parkinson Disease;PDPK1 gene;Phase;phosphatidylinositol 3,4,5-triphosphate;phosphoinositide-3,4,5-triphosphate;Phosphorylation;PIK3CA gene;PIK3CG gene;Process;Production;Proteins;Proteolysis;Proteome;Proto-Oncogene Proteins c-akt;ratiometric;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Reporter;Resistance;Ribosomes;Role;Serum;side effect;Signal Transduction;Small Interfering RNA;small molecule inhibitor;Starvation;System;Techniques;Therapeutic;trafficking;translational potential;Translations;tumorigenesis;uptake

PROJECT_TITLE: Endocytosis and Endolysosomal Trafficking of Receptor Tyrosine Kinases in the Regulation of Chaperone-Mediated Autophagy


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PI_NAMEs: BOYLE, JESSICA  (contact)

PROJECT_TERMS: Advisory Committees;Age;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Area;Biological;Biological Assay;Biology;Body Fluids;Breeding;Catalogs;Cell Separation;Cell Therapy;cell type;Cells;Communities;Complementary DNA;Contracts;Custom;Data;Databases;Deposition;Diet;Disease;disease model;Enzyme-Linked Immunosorbent Assay;experimental study;Farm;Ferrets;Fluorescence-Activated Cell Sorting;Funding;Gene Expression;Genes;Genetic;Genetic Engineering;Genetically Modified Animals;Genome;Goals;Grant;Health;Human;Human Resources;Immunoprecipitation;improved;In Situ Hybridization;Industrialization;Institution;Knock-in;Knock-out;Label;Left;Lung;Lung Diseases;Manuscripts;material transfer agreement;Messenger RNA;Methods;Mission;Modeling;Mus;National Heart, Lung, and Blood Institute;Outcome;pharmacologic;Phenotype;Physiological;Preparation;Procedures;Protocols documentation;Pulmonary function tests;Reagent;recombinant virus;Records;repository;Research;Research Personnel;Resources;RNA;sample collection;Sampling;single-cell RNA sequencing;Site;Source;Specimen;stem cell biology;stem cell therapy;Techniques;Technology;Testing;Therapeutic Agents;therapeutic evaluation;Tissue Model;Tissue Sample;Tissues;Training;Transgenic Organisms;United States Department of Agriculture;United States National Institutes of Health;web site;Western Blotting

PROJECT_TITLE: NATIONAL FERRET RESOURCE AND RESEARCH CENTER ON LUNG DISEASE


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

PROJECT_TERMS: Academia;anti-cancer research;biopharmaceutical industry;Cancer Center;cancer genomics;Cancer Model;Catalogs;Clinical;clinical diagnostics;Communities;Data;data modeling;Data Sources;Foundations;Genomic Data Commons;Genomics;Goals;Human;In Vitro;Institution;Intellectual Property;interest;International;Libraries;Malignant Neoplasms;member;Methods;model development;Modeling;Molecular;National Cancer Institute;next generation;novel;Office of Cancer Genomics;Online Systems;Organoids;query tools;Research Personnel;Resources;response;Source;System;Technology;Tissue Donors;Trust

PROJECT_TITLE: HCMI Searchable Catalog


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Patient Safety

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PI_NAMEs: CAPPO, JAMES  (contact)

PROJECT_TERMS: Address;adjudication;Adverse event;Ancillary Study;Annual Reports;Applications Grants;Archives;Area;Award;biobank;Bioinformatics;Biological Markers;Biological Specimen Banks;Blood specimen;Bronchodilator Agents;catalyst;Cause of Death;Certification;Cessation of life;Characteristics;Chest;Chronic Obstructive Pulmonary Disease;Clinical;clinical center;Clinical Data;clinical phenotype;Clinical Research;clinical research site;Clinical/Radiologic;cohort;Collaborations;Collection;Communication;Communities;Compensation;Computer Security;Contractor;Contracts;cost;COVID-19;COVID-19 impact;Data;Data Analyses;Data Coordinating Center;data format;data management;data quality;data repository;data resource;Data Science;Data Security;Data Set;data sharing;data submission;database of Genotypes and Phenotypes;Databases;demographics;Development;Diagnostic;Diffusion;digital;Disease Progression;disorder subtype;DNA Methylation;Documentation;Educational workshop;Elderly;Electronics;Enrollment;Ensure;epidemiologic data;Epidemiology;Evaluation;Event;follow-up;follower of religion Jewish;former smoker;frailty;Funding;Funding Opportunities;Future;Genes;Genetic;genetic analysis;genetic epidemiology;genome sequencing;Genomics;Goals;Grant;Health;high risk;Hospitals;human subject protection;Image;image processing;imaging facilities;Impairment;Information Systems;Institutional Review Boards;International;Internet;Journals;Laboratories;Link;Longitudinal cohort study;Longterm Follow-up;Maintenance;Manuscripts;Measures;Medical History;meetings;member;metabolomics;Metadata;Methods;Molecular;Monitor;Names;National Heart, Lung, and Blood Institute;Natural History;new technology;non-smoking;Observational Study;Outcome;Oxygen;Parents;Participant;Peer Review;Persons;Phase;Physical Performance;Physiological;Physiology;Policies;preservation;Privatization;Procedures;prognostic;programs;Proteomics;Protocols documentation;Publications;Publishing;PubMed;Pulmonary Emphysema;Pulmonary function tests;quality assurance;Quality Control;Quality of life;Questionnaires;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resolution;Resources;Risk Factors;SARS-CoV-2 infection;Scanning;Schedule;Scientist;serial imaging;Site;smoking-related disease;socioeconomics;Specific qualifier value;Spirometry;Standardization;Subgroup;Support Contracts;System;Teleconferences;Telephone;Testing;Therapeutic;Time;Tobacco use;Training;Trans-Omics for Precision Medicine;transcriptome sequencing;Travel;U-Series Cooperative Agreements;United States National Institutes of Health;Update;Vaccination;Visit;Walking;web site;whole genome;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: GENETIC EPIDEMIOLOGY OF COPD (COPD GENE)  2024 - 2025 TASK ORDER FOR TASK AREA A: COLLECTION OF COPDGENE STUDY DATA AND BIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY.


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

PI_NAMEs: ANDERSON, ERICA  (contact)

PROJECT_TERMS: Address;Adverse event;Airway Disease;Ancillary Study;Annual Reports;Archives;Area;Atmosphere;Award;biobank;Biochemical;Biological Specimen Banks;Blood;Bronchodilator Agents;catalyst;Certification;Characteristics;Chronic Obstructive Pulmonary Disease;Clinic Visits;Clinical;clinical center;Clinical Data;clinical research site;cohort;Cohort Studies;Collection;Communication;Communities;Companions;Compensation;Complete Blood Count;Computer Security;Contractor;Contracts;Data;Data Coordinating Center;data de-identification;data format;data integration;data quality;data repository;Data Science;Data Security;Data Set;data sharing;data submission;database of Genotypes and Phenotypes;demographics;Deposition;detector;Development;digital;Dimensions;Disease;Disease Progression;Documentation;Electronics;Enrollment;Ensure;Environmental Exposure;Environmental Monitoring;Environmental Risk Factor;Event;Exposure to;follow-up;Funding;genomic data;Genomics;Goals;Grant;Hand;Hand Strength;Heterogeneity;image processing;imaging facilities;imaging modality;Individual;Informatics;Information Dissemination;Information Systems;Institutional Review Boards;International;Internet;Intervention;Journals;Laboratories;Link;Longterm Follow-up;Lung Diseases;lung volume;Maintenance;Manuscripts;Measures;Medical History;meetings;member;Metadata;Methods;Molecular;Monitor;MUC5AC gene;MUC5B gene;Mucous body substance;multiple omics;Names;National Heart, Lung, and Blood Institute;Natural History;Nature;new technology;novel;Observational Study;Oscillometry;Outcome;Ownership;Participant;participant enrollment;Pathologic;Peer Review;Persons;Phenotype;Physical Performance;Policies;Population;preservation;Procedures;programs;Progress Reports;Proteins;Protocols documentation;Publications;PubMed;Pulmonary Emphysema;pulmonary function;Pulmonary function tests;quality assurance;Quality Control;Quality of life;Questionnaires;radiological imaging;Recommendation;Refractive Indices;Reporting;repository;Research;Research Personnel;Resources;respiratory;retention rate;Role;SARS-CoV-2 infection;Scanning;Schedule;Scientist;Smoker;Smoking;Smoking History;Social Environment;social health determinants;socioeconomics;Source;Specific qualifier value;Spirometry;Sputum;Standardization;Statistical Data Interpretation;Support Contracts;Symptoms;System;Telephone;Testing;Time;Tobacco use;Training;Trans-Omics for Precision Medicine;Travel;United States National Institutes of Health;Update;Urine;Vaccination;vascular abnormality;Visit;Walking;web site;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: SUBPOPULATIONS AND INTERMEDIATE OUTCOMES IN COPD (SPIROMICS) III - TASK AREA A


PROJECT_TITLE: SUBPOPULATIONS AND INTERMEDIATE OUTCOMES IN COPD (SPIROMICS) III - TASK AREA B


ORG_CITY: WILMINGTON

ORG_NAME: CHARLES RIVER LABORATORIES INTNTL, INC.

PI_NAMEs: STUMP, DONALD  (contact)

PROJECT_TITLE: KICK-OFF MEETING FOR SAFETY EVALUATION AND TOXICOLOGY STUDIES AND RELATED SERVICES FOR DRUG DEVELOPMENT


ORG_CITY: MONROVIA

ORG_NAME: CONCEPT TO MARKET LLC

PROJECT_TERMS: meetings

PROJECT_TITLE: CMC Kick Off meeting


ORG_NAME: POLYPEPTIDE LABORATORIES SAN DIEGO

PROJECT_TERMS: meetings;polypeptide

PROJECT_TITLE: CMC-DS IDIQ Kick-Off Meeting for PolyPeptide Labs


ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

PI_NAMEs: BARRETT, EDWARD  (contact)

PROJECT_TERMS: animal model development;Contracts;drug development;meetings;Pharmacology Study;Services;Study models

PROJECT_TITLE: KICK-OFF MEETING FOR THE PHARMACOLOGY STUDIES AND ANIMAL MODEL DEVELOPMENT AND RELATED SERVICES FOR DRUG DEVELOPMENT IDIQ CONTRACT.


ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

PI_NAMEs: HORN, THOMAS  (contact)

PROJECT_TERMS: Agonist;Canis familiaris;Immunologics;Malignant Neoplasms;Oral;Organ;Recovery;small molecule;Solid;Toxic effect;Toxicokinetics

PROJECT_TITLE: FIRST-IN-CLASS SMALL MOLECULE CANDIDATE NCGC72 (CD206 AGONIST) FOR IMMUNOLOGICALLY COLD SOLID ORGAN CANCERS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PI_NAMEs: SLADE, DESMOND  (contact)

PROJECT_TITLE: PROCESS DEVELOPMENT OF TELACEBEC FOR TUBERCULOSIS


ORG_CITY: MCLEAN

PROJECT_TERMS: manufacture;National Center for Advancing Translational Sciences;Plasmids;therapeutic development;United States National Institutes of Health

PROJECT_TITLE: NATIONAL INSTITUTES OF HEALTH (NIH), NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS), THERAPEUTIC DEVELOPMENT BRANCH (TDB), GMP MANUFACTURE AND STABILITY STUDIES OF HBMP-6 PLASMID


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SACRAMENTO

PROJECT_TERMS: Brain;induced pluripotent stem cell;Patients;single-cell RNA sequencing;transcriptomic profiling;X-Linked Mental Retardation

PROJECT_TITLE: TRANSCRIPTOME PROFILING IN BAIN TYPE X-LINKED MENTAL RETARDATION SYNDROME (MRXSB) PATIENT'S IPSC-GENERATED BRAIN ORGANIODS BY USING SCRNA-SEQ


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Rockville

ORG_NAME: CODEX BIOSOLUTIONS, INC.

PI_NAMEs: NGUYEN, NAM  (contact)

PROJECT_TERMS: Brain;Generations;induced pluripotent stem cell;Organoids;X-Linked Mental Retardation

PROJECT_TITLE: GENERATION AND CHARACTERIZATION IPSC DERIVED BRAIN ORGANOIDS FROM BAIN TYPE X-LINKED MENTAL RETARDATION SYNDROME (MRXSB)


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

PI_NAMEs: FARMER, JOHN  (contact)

PROJECT_TERMS: Fracture;therapeutic gene

PROJECT_TITLE: CHARACTERIZATION OF A DOWNSTREAM GENE THERAPEUTIC FOR THE REPARATIVE TREATMENT OF SEVERE FRACTURES.


PROJECT_TITLE: DOSAGE FORM REPROCESS AND STABILITY STUDIES OF FX-5A INJECTION UNDER IDIQ CHEMISTRY, MANUFACTURING AND CONTROLS AND RELATED SERVICES FOR DEVELOPMENT OF DRUG PRODUCTS


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: SCHACHTER, STEVEN C.  (contact)

PROJECT_TERMS: Acceleration;Businesses;Clinical;commercialization;Communication;Complex;data management;Development;Diagnostic;diagnostic technologies;Electronics;endometriosis;Evaluation;Funding;Goals;innovation;point of care;Procedures;Process;Progress Reports;RADx;Resources;Schedule;Services;United States National Institutes of Health;web site

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR ENDOMETRIOSIS DIAGNOSTICS - COORDINATION CENTER


ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: MARINO, MARK  (contact)

PROJECT_TERMS: Acceleration;Clinical;commercialization;Development;Diagnostic;diagnostic technologies;endometriosis;Goals;innovation;parallelization;point of care;RADx;Resources;risk mitigation;Services;Speed;technology development;United States National Institutes of Health;Vendor

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR ENDOMETRIOSIS DIAGNOSTICS - COMMERCIALIZATION CENTER


PI_NAMEs: WANG, GENSHENG  (contact)

PROJECT_TERMS: Animal Model;Animals;Area;Biodistribution;Biological Assay;Collaborations;Contractor;Emerging Technologies;Funding;gene therapy;Gene Transduction Agent;Gene Transfer;good laboratory practice;Laboratories;new technology;nonhuman primate;Pharmacology and Toxicology;pre-clinical;programs;Regulation;Research Personnel;Resources;Rodent;Technology;Testing;vector

PROJECT_TITLE: GENE THERAPY RESOURCE PROGRAM (GTRP): PHARMACOLOGY AND TOXICOLOGY CORE LABORATORY - TASK AREA A:  CORE ADMINISTRATIVE ACTIVITIES


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -   WHOLE GENOME SEQUENCING, 30X COVERAGE FOR NEI (SHEN)


NIH_SPENDING_CATS: Cancer;Nutrition

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: MILLER, AMY  (contact)

PROJECT_TITLE: NCI SUPPORT FOR THE EXISTING AUTOMATED SELF-ADMINISTERED 24-HOUR DIETARY ASSESSMENT SYSTEM


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: JOHNSTON, JULIE  (contact)

PROJECT_TITLE: GENE THERAPY RESOURCE PROGRAM (GTRP),TASK AREA A: CORE ADMINISTRATIVE TASKS


ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: PATTON, LISA  (contact)

PROJECT_TERMS: Animal Model;Animals;Area;Biodistribution;Biological Assay;Clinical;Collaborations;Contractor;Emerging Technologies;Funding;gene therapy;Gene Transduction Agent;Gene Transfer;good laboratory practice;Laboratories;new technology;nonhuman primate;Pharmacology and Toxicology;pre-clinical;programs;Regulation;Research Personnel;Resources;Rodent;Technology;Testing;vector

PROJECT_TITLE: GENE THERAPY RESOURCE PROGRAM (GTRP) - CLINICAL COORDINATING CENTER: TASK AREA A: CORE ADMINISTRATIVE ACTIVITIES


NIH_SPENDING_CATS: Cancer

ORG_CITY: ALACHUA

ORG_NAME: ALCHEM LABORATORIES CORPORATION

ORG_STATE: FL

PI_NAMEs: TALTON, JIM  (contact)

PROJECT_TERMS: Deoxycytidine;manufacture

PROJECT_TITLE: DFMC- THE PURPOSE OF THIS TASK ORDER IS TO MANUFACTURE AND DELIVER 2200 CAPSULES OF 4MG AZA-TDC (5-AZA-4-THIO-2-DEOXYCYTIDINE)


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: STRAUGHN, JEREMY  (contact)

PROJECT_TERMS: catalyst;Cells;Contractor;Data;database of Genotypes and Phenotypes;Databases;Development;Disease;functional genomics;Funding;genome sequencing;genomic data;Goals;Heart;Hematological Disease;Informatics;Lung;Multiomic Data;National Heart, Lung, and Blood Institute;Phase;precision medicine;Process;programs;Research;Research Personnel;Resolution;Resources;Sleep Disorders;Trans-Omics for Precision Medicine;whole genome

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) INFORMATICS RESEARCH CENTER (IRC)


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: RIVES, MICHELLE  (contact)

PROJECT_TERMS: Area;catalyst;Cells;Contractor;Contracts;cost;Data;Data Analyses;data exchange;database of Genotypes and Phenotypes;Databases;Development;Disease;follow-up;functional genomics;Funding;genome sequencing;genome-wide;genomic data;Goals;Heart;Hematological Disease;Logistics;Lung;Manuals;metabolomics;Methods;Multiomic Data;National Heart, Lung, and Blood Institute;operation;Phase;precision medicine;Process;programs;protein profiling;Protocols documentation;Publications;Research Personnel;Resolution;Resources;Sampling;Secure;Services;Sleep Disorders;Standardization;timeline;Trans-Omics for Precision Medicine;transcriptome sequencing;Update;Vendor;whole genome;Work

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4 - 2024 TASK ORDER


NIH_SPENDING_CATS: Cancer;Clinical Research;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CARUSI, CHARLES  (contact)

PROJECT_TERMS: Country;Health;Longitudinal Studies;Performance;Persons;Population Assessment of Tobacco and Health;Research;Tobacco;Tobacco use;United States;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: POPULATION ASSESSMENT OF TOBACCO AND HEALTH (PATH) STUDY PERIOD OF PERFORMANCE: 02/01/2024 - 01/31/2029


ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

ORG_STATE: DC

PI_NAMEs: DAY, ROBERT  (contact)

PROJECT_TERMS: Engineering;frontier;Science;statistics

PROJECT_TITLE: PARTIAL SUPPORT OF THE STUDY ON FRONTIERS OF STATISTICS FOR SCIENCE AND ENGINEERING: 2035 AND BEYOND


NIH_SPENDING_CATS: Bioengineering

PROJECT_TERMS: Acceleration;Clinical;cohort;commercialization;Device or Instrument Development;Diagnosis;Goals;Nervous System Disorder;RADx;Resources;risk mitigation;Services;technology development;United States National Institutes of Health

PROJECT_TITLE: RADX BLUEPRINT MEDTECH TRANSLATOR COHORT 1 - COMMERCIALIZATION CENTER


PI_NAMEs: SAVAGE, TERRY  (contact)

PROJECT_TERMS: Address;Awareness;Breathing;Communication;disorder prevention;Education;Education and Outreach;Goals;Health education;Health Promotion;Learning;Lung;Lung Diseases;lung health;National Heart, Lung, and Blood Institute;outreach program;Professional Education;programs;public education;Research;Resources;Science;Services;Translating

PROJECT_TITLE: BPA ORDER TITLED "LUNG HEALTH EDUCATION AND OUTREACH PROGRAMS" AGAINST THE NHLBI COMMUNICATIONS, ENGAGEMENT, AND EDUCATION SUPPORT SERVICES BPA II.


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PROJECT_TERMS: Awareness;Cardiac health;Cause of Death;Communication;Education;Education and Outreach;Health education;Heart;Heart Diseases;National Heart, Lung, and Blood Institute;outreach program;programs;Resources;Science;Services;Women's mortality

PROJECT_TITLE: BPA ORDER TITLED "HEART HEALTH EDUCATION AND OUTREACH PROGRAMS" AGAINST THE NHLBI COMMUNICATIONS, ENGAGEMENT, AND EDUCATION SUPPORT SERVICES BPA II.


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: DOHENY, KIM  (contact)

PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -EPIC METHYLATION ARRAY FOR NCI


ORG_CITY: ARLINGTON

ORG_NAME: FORS MARSH GROUP LLC

ORG_STATE: VA

PI_NAMEs: FOLEY, NICK  (contact)

PROJECT_TERMS: Address;Awareness;Blood;Clinical Trials;Communication;Disease;Education;Health;Health education;Hematological Disease;National Heart, Lung, and Blood Institute;outreach program;programs;Research;Resources;Safety;Science;Services

PROJECT_TITLE: BPA ORDER TITLED "BLOOD HEALTH EDUCATION AND OUTREACH PROGRAMS" AGAINST THE NHLBI COMMUNICATIONS, ENGAGEMENT, AND EDUCATION SUPPORT SERVICES BPA II.


PROJECT_TERMS: Communities;Contracts;Disease;DNA sequencing;exome sequencing;Genes;Genetic;Genetic Services;Genetic study;genome sequencing;Genotype;Goals;Health;Hereditary Disease;Human;Modification;Parents;Research;Saliva;Services;whole genome

PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -WHOLE EXOME SEQUENCING (SALIVA); WHOLE GENOME SEQUENCING UPGRADE FOR NCI


PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE - EPIC METHYLATION ARRAY & GDA ARRAY FOR NCI


PROJECT_TERMS: Communities;Contracts;Disease;DNA sequencing;exome sequencing;Genes;Genetic;Genetic Services;Genetic study;Genotype;Goals;Health;Hereditary Disease;Human;Modification;Parents;Research;Services

PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -  WHOLE EXOME SEQUENCING FOR NCI


PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -   ILLUMINA GLOBAL DIVERSITY ARRAY FOR NCI


PROJECT_TERMS: Animal Experimentation;Basic Science;Complement;crowdsourcing;Disease;Funding;Human Biology;human model;innovation;Investments;Knowledge;Methodology;Modeling;novel strategies;Prize;Process;programs;Research;Standardization;Strategic Planning;Translating;United States National Institutes of Health

PROJECT_TITLE: Complement-ARIE OD (Complement-Animal Research In Experimentation) Challenge


PROJECT_TERMS: Acceleration;Area;Clinical;Collaborations;commercialization;Development;diagnostic technologies;Goals;Government;Home;Industry;innovation;Institution;Knowledge;multidisciplinary;network models;new technology;point of care;Point of Care Technology;Readiness;Research;Resources;support network;Technology;technology development;technology research and development

PROJECT_TITLE: POCTRN SUPPORT - COORDINATION CENTER


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: UNIVERSITY OF CHICAGO

PI_NAMEs: GIGER, MARYELLEN  (contact)

PROJECT_TERMS: Acceleration;Area;Clinical;Collaborations;commercialization;data resource;Development;diagnostic technologies;Goals;Government;Home;Industry;innovation;Institution;Knowledge;Medical Imaging;multidisciplinary;network models;new technology;point of care;Point of Care Technology;Readiness;Research;Resources;Technology;technology development;technology research and development

PROJECT_TITLE: MEDICAL IMAGING AND DATA RESOURCE CENTER (MIDRC) YEAR 3


ORG_CITY: Bethesda

ORG_NAME: ASSOCIATION /PUBLIC HEALTH LABORATORIES

PI_NAMEs: GARRETT, BRIAN  (contact)

PROJECT_TERMS: Acceleration;Area;Clinical;Collaborations;commercialization;Development;diagnostic technologies;Goals;Government;Home;Industry;innovation;Institution;Knowledge;multidisciplinary;network models;new technology;point of care;Point of Care Technology;Readiness;Reporting;Research;Resources;Technology;technology development;technology research and development;Testing

PROJECT_TITLE: APHL OVER THE COUNTER (OTC) TEST MESSAGE REPORTING


PI_NAMEs: NEAL, REBEKAH  (contact)

PROJECT_TERMS: Acceleration;Biomedical Engineering;biomedical imaging;Biomedical Technology;Clinical;Contracts;design;Development;experience;Goals;Health;Healthcare;improved;innovation;Mission;Modality;National Institute of Biomedical Imaging and Bioengineering;novel;open-ended problem;programs;Research Support;Technology;tool;Training;undergraduate student

PROJECT_TITLE: DEBUT CHALLENGE MANAGEMENT CONTRACT


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Maternal Health;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: LAM, WILBUR  (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Chronic Disease;Clinical;commercialization;Communicable Diseases;Development;Diagnostic;Fetal health;Goals;Health;Health Technology;Hepatitis B;Home;innovation;Maternal Health;Monitor;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;neural stimulation;new technology;point of care;prototype;RADx;sensor;Speed;Technology;technology development;technology validation;United States National Institutes of Health;Validation;verification and validation

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HEALTH TECHNOLOGIES - VALIDATION CENTER


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Maternal Health;Neurodegenerative;Neurosciences;Women's Health Research

PI_NAMEs: SCHACHTER, STEVEN C.  (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Chronic Disease;Clinical;commercialization;Communicable Diseases;Development;Diagnostic;Fetal health;Goals;Health;Health Technology;Hepatitis B;Home;innovation;Maternal Health;Monitor;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;neural stimulation;new technology;point of care;prototype;RADx;sensor;Speed;Technology;technology development;United States National Institutes of Health;Validation;verification and validation

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HEALTH TECHNOLOGIES - COORDINATION CENTER


NIH_SPENDING_CATS: Lung;Prevention

PROJECT_TERMS: Address;Awareness;Breathing;Communication;disorder prevention;Education;Goals;Health education;Health Promotion;Learning;Lung;Lung Diseases;lung health;Mission;National Heart, Lung, and Blood Institute;Professional Education;programs;public education;Research;Resources;Science;Services;Translating

PROJECT_TITLE: BPA ORDER TITLED "EXTERNAL ENGAGEMENTS AND PARTNERSHIPS IN SUPPORT OF THE NHLBI MISSION" AGAINST THE NHLBI COMMUNICATIONS, ENGAGEMENT, AND EDUCATION SUPPORT SERVICES BPA II.


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PI_NAMEs: MARINO, MARK  (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Chronic Disease;Clinical;commercialization;Communicable Diseases;Development;Diagnostic;Fetal health;Goals;Health;Health Technology;Hepatitis B;Home;innovation;Maternal Health;Monitor;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;neural stimulation;new technology;point of care;RADx;Resources;sensor;Services;Speed;Technology;technology development;United States National Institutes of Health

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HEALTH TECHNOLOGIES - COMMERCIALIZATION CENTER


ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: Narrative We aim to inhibit tumor growth and prevent disease recurrence by blocking the molecules that facilitate cancer development. We will find these molecules in genetically engineered mice that resemble humans in their cancer development to allow for mapping of cancer facilitating molecules. We will test if blocking LILRB4, the first candidate molecule we found and verified with human cancer data, will boost immune response and inhibit tumor growth.

PI_NAMEs: JACOB, JENNIFER B (contact);KIDDER, BENJAMIN L

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: Acceleration;Active Immunization;Age of Onset;Algorithms;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Atlas of Cancer Mortality in the United States;Binding;bioinformatics pipeline;Biological Assay;Biological Process;Breeding;Cancer Intervention;Cancer Patient;cancer risk;cancer survival;Cancer Vaccines;Candidate Disease Gene;candidate identification;carcinogenesis;Cell Line;Cells;Chromosomes;Clinical;Clinical Trials;Code;Data;Data Set;Development;disorder control;DNA;Enhancers;Equilibrium;ERBB2 gene;Fatty acid glycerol esters;Foundations;functional genomics;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic linkage analysis;Genetic Polymorphism;Genetically Engineered Mouse;Genome;genome wide association study;Genotype;Goals;Growth;Haplotypes;Human;Immune;immune activation;Immune response;Individual;Intercistronic Region;Intervention;Knock-out;Laboratories;Length;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary;Mammary Neoplasms;Measures;Modeling;Monoclonal Antibody Therapy;mosaic;Mus;Mutation;Myelogenous;Myeloid Cells;Natural Killer Cells;neoplastic cell;Normal Cell;Oncogenes;Open Reading Frames;Outcome;Pathway Analysis;Phenotype;prevent;Production;Proteins;Quantitative Trait Loci;Rattus;Reagent;Recurrent disease;Regulator Genes;risk variant;Role;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Testing;Tissue-Specific Gene Expression;transcription factor;transcriptomics;Transgenic Mice;Translational Research;tumor;Tumor Antigens;Tumor Expansion;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppressor Genes;vaccine response

PROJECT_TITLE: Defining Cancer Intervention Targets by Functional Genomics Analysis of Outbred F1 Mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Calcium homeostasis modulators (CALHMs) constitute a family of nonselective ion channels that are permeable to the signaling molecules calcium and ATP; they are thus critically involved in calcium and purinergic signaling. The proposed study focuses on uncovering the oligomeric state, multichannel assembly, molecular structure, gating mechanism, and pharmacology of the CALHMs, taking advantage of single- particle cryo-EM, electrophysiology, and other functional approaches. The proposed research is relevant to public health and NIH's mission because this work will provide a deep understanding and broaden our knowledge of the relationships between atomic structures and the complex biological and pathological functions of CALHMs, paving the way for the development of therapeutics to treat neurological diseases including Alzheimer disease, ischemic brain damage, and depression.

PI_NAMEs: LU, WEI  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TITLE: Structural and functional studies of CALHM channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PI_NAMEs: ADRIANZEN HERRERA, DIEGO  (contact);NELSON, MARK T

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Area;Biological;Biological Assay;Biological Markers;brain health;Cancer Etiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Models;Cardiovascular system;Cause of Death;Cells;Clinical;Clinical Data;clinical practice;Clinical Research;cohort;Dysmyelopoietic Syndromes;Enrollment;epidemiology study;Future;Goals;Hematologic Neoplasms;Hematopoietic;Hospitals;improved;Inflammation;Inflammatory;interest;Life;Link;Measures;Mediating;Medical center;Medicare;Modeling;Molecular Epidemiology;Morbidity - disease rate;mortality;mortality risk;Mutation;new technology;Observational Study;Patients;Persons;Pilot Projects;Population;predictive tools;Preventive;Procedures;Proteins;Proteome;Proteomics;recruit;Registries;Research;Research Design;Risk;Risk Assessment;Risk Factors;risk prediction;SEER Program;Source;Statistical Data Interpretation;Time;Translating;Translational Research;Universities;Variant;vascular inflammation;Vermont

PROJECT_TITLE: Risk Prediction and Inflammatory Biomarkers of Cardiovascular Disease in Myelodysplastic Syndrome


ORG_CITY: TULSA

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

ORG_STATE: OK

PI_NAMEs: CROFF, JULIE MAY (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: CIRCA Administrative Core


PI_NAMEs: MORRIS, AMANDA S (contact)

PROJECT_TITLE: Recruitment, Engagement, Collection, and Analysis Core


PI_NAMEs: SIMMONS, WILLIAM KYLE (contact)

PROJECT_TITLE: Biological Systems Core


PI_NAMEs: CICIOLLA, LUCIA MARIE (contact)

PROJECT_TITLE: The Impact of Maternal Adversity and Attachment Security on Infant Stress Reactivity: Prenatal Epigenetic Pathways


PI_NAMEs: FORD, BART NOLAN (contact)

PROJECT_TITLE: Immune Genomics and COVID-19 Vaccine Response in Adults with Adverse Childhood Experiences


PI_NAMEs: KERR, KARA  (contact)

PROJECT_TITLE: Dyadic Neurofeedback for Development of Healthy Emotion Regulation in Youth


PROJECT_TERMS: Adoptive Cell Transfers;Affinity;Agreement;antigen binding;antigen-specific T cells;Antigens;Autoimmunity;autoreactivity;Award;Back;bench to bedside;Binding;cancer therapy;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Surface Receptors;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Community Health;Complex;Conserved Sequence;cross reactivity;Cytoplasmic Tail;Cytotoxic T-Lymphocytes;Data;Dependence;design;Discrimination;education research;engineered T cells;expectation;Experimental Models;Extramural Activities;Funding;Funding Opportunities;Gene Expression Profile;Growth;Human;Human Activities;humanized mouse;improved;in vivo;innovation;ITAM;Ligand Binding;Ligands;Love;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Methods;Modality;Modification;mouse model;Mus;mutant;National Institute of Child Health and Human Development;neoantigens;neoplasm immunotherapy;novel;novel strategies;outreach;Peptides;Phenotype;pre-clinical;Principal Investigator;programs;Proteins;receptor;receptor binding;Receptor Signaling;Reporter;Research Project Grants;Research Support;response;Role;Scientist;Services;Signal Transduction;Single Nucleotide Polymorphism;T cell response;T Chain;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Toxic effect;Translational Research;Treatment Efficacy;Treatment Protocols;tumor;Tumor Antigens;tumor infiltrating lymphocyte therapy;Tumor-Infiltrating Lymphocytes;Tyrosine;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: INTER-AGENCY SERVICE (NIH)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Annually, almost 8 million1 children are reported to child protective services for potential maltreatment; given the significant individual and societal costs of child maltreatment (CM), it is critical to develop programs to prevent and reduce its recurrence. The proposed project aims to adapt an online educational intervention to equip parents and primary caregivers with a better understanding of what qualifies as CM, strategies to reduce their child’s risk of CM from other adults, and skills to improve parent competency to manage their child’s difficult behavior, to thereby reduce children’s risk of CM. The intervention will adapt existing content and leverage innovative training methodologies from iLookOut, an evidence-based, online training2–4; the proposed intervention will incorporate input from end-users at all stages of development and implementation to ensure feasibility, usefulness, and implementation success.

PI_NAMEs: BARNETT, WHITNEY CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TITLE: Adapting a web based parent training to reduce child maltreatment

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Patient Safety

ORG_CITY: NORTH BETHESDA

ORG_NAME: AXLE INFORMATICS, LLC

PI_NAMEs: MAYS, GARY  (contact)

PROJECT_TERMS: Agreement;base;Clinical and Translational Science Awards;common rule;Communication;Communities;Contracts;Documentation;Funding;human subject;human subject protection;Institution;Institutional Review Boards;Mediation;National Center for Advancing Translational Sciences;prevent;Process;programs;Research;Services;Site;System;United States National Institutes of Health;Universities;user-friendly

PROJECT_TITLE: BASE CONTRACT TITLE:  NCATS SCIENTIFIC AND TECHNICAL SUPPORT SERVICES (STSS) 2.5.TASK ORDER TITLE: SMART IRB ONLINE RELIANCE SYSTEM (ORS) AND JOINDER ENHANCEMENTS.


PROJECT_TERMS: analytical tool;Area;Clinical and Translational Science Awards;Clinical Data;Clinical Research;cloud based;cohort;Collaborations;Communities;Complex Analysis;Contracts;COVID-19;COVID-19 patient;Data;Data Analyses;Data Collection;data enclave;data harmonization;data platform;Data Science;Data Set;Electronic Health Record;Environment;genetic variant;Genomics;Health;Image;Informatics;Information Technology;Ingestion;meetings;multimodal data;National Center for Advancing Translational Sciences;open source;open source tool;Pathology;Privacy;Productivity;programs;protective factors;Pythons;Radiology Specialty;Research;Research Personnel;Risk Factors;Scientist;Secure;Security;Services;Statistical Data Interpretation;synthetic data;tool;United States;United States National Institutes of Health;Viral;virtual;Visualization;Work

PROJECT_TITLE: NATIONAL CLINICAL DATA COLLABORATIVE COUNTS (NACDACC)


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: MCLEAN

ORG_NAME: A-TEK, INC.

PROJECT_TITLE: SYSTEM ADMINISTRATION AND MANAGEMENT SUPPORT FOR BIOMEDICAL AND BIBLIOGRAPHIC INFORMATION RESOURCES


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Rare Diseases;Rehabilitation

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

ORG_STATE: MA

PI_NAMEs: VAZIRI, ASHKAN  (contact)

PROJECT_TERMS: Activities of Daily Living;Clinical;Clinical Trials;cognitive function;Conduct Clinical Trials;Data;data platform;Decentralization;Development;Disease;Electronics;Enrollment;Exclusion;Home;improved;Individual;Measurement;mobile computing;Monitor;Motor;multimodality;Participant;Rare Diseases;Secure;sensor;Site;Source;Speech;study population;Study Subject;Technology;Testing;Translational Research;virtual


ORG_CITY: ROCKVILLE

ORG_NAME: ON DEMAND PHARMACEUTICALS, INC.

PI_NAMEs: MCQUADE, TYLER  (contact)

PROJECT_TERMS: analog;Animals;Chemicals;Chemistry;Development;Devices;Engineering;innovation;manufacturing capabilities;manufacturing systems;Operations Research;Pharmacologic Substance;Phase;Preclinical Drug Development;Research;scale up;Small Business Innovation Research Grant;Speed;Time;tool

PROJECT_TITLE: SMALL MANUFACTURING SYSTEMS TO PRODUCE RESEARCH GRADE PHARMACEUTICAL INTERMEDIATES-DIVERSITY ON DEMAND- SBIR PHASE 1 TOPIC 024


ORG_CITY: LEAVENWORTH

ORG_STATE: KS

PI_NAMEs: CROUSE, ANDY  (contact)

PROJECT_TERMS: Address;Adverse event;Biological;Biomedical Research;Cell Physiology;Clinical;Clinical Trials;Data;Data Sources;data translator;Development;Disease;Drug Design;Functional disorder;Health;health record;insight;interoperability;Location;Molecular;n-dimensional;National Center for Advancing Translational Sciences;Patients;Persons;Pharmaceutical Preparations;programs;Reporting;Scientific Advances and Accomplishments;Signs and Symptoms

PROJECT_TITLE: BIOMEDICAL DATA TRANSLATOR USER INTERFACE DEVELOPMENT


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TERMS: Address;Biodistribution;Biological Assay;Biomedical Computing;Biomedical Research;Canis familiaris;Cells;Clinical;Clinical Trials;comparative;Computational Science;coronavirus pandemic;COVID-19;Data Analyses;data integration;data resource;Development;Drug Kinetics;efficacy study;Electron Microscopy;Gene Expression;Image;Laboratory Animals;manufacture;Methods;novel coronavirus;Oncology;Pharmaceutical Preparations;pre-clinical;Proteomics;Public Health;Rare Diseases;screening;Serology test;Services;Standardization;therapeutic development;Translational Research;Validation

PROJECT_TITLE: THE COVID 19 SERVICES CATALYZE TRANSLATIONAL RESEARCH FINDINGS INTO PUBLIC HEALTH CHANGES TO ADDRESS THE NOVEL CORONAVIRUS PANDEMIC THROUGH IMPLEMENTATION OF STANDARDIZED SEROLOGY TESTING FOR ITS INTE


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: analytical tool;Area;Clinical and Translational Science Awards;Clinical Research;cloud based;cohort;Collaborations;Communities;Complex Analysis;Contracts;COVID-19;COVID-19 patient;Data;Data Analyses;Data Collection;data enclave;data harmonization;data platform;Data Science;Data Set;Electronic Health Record;Environment;genetic variant;Genomics;Health;Image;Informatics;Information Technology;Ingestion;meetings;multimodal data;National Center for Advancing Translational Sciences;open source;open source tool;Pathology;Privacy;Productivity;programs;protective factors;Pythons;Radiology Specialty;Research;Research Personnel;Risk Factors;Scientist;Secure;Security;Services;Statistical Data Interpretation;synthetic data;Technology;tool;United States;United States National Institutes of Health;Viral;virtual;Visualization;Work

PROJECT_TITLE: NCATS SCIENTIFIC AND TECHNOLOGY SUPPORT SERVICES (STSS)


PI_NAMEs: COLLINS, JACK  (contact)

PROJECT_TERMS: analytical tool;Area;Clinical and Translational Science Awards;Clinical Research;cloud based;cohort;Collaborations;Communities;Complex Analysis;Contracts;COVID-19;COVID-19 patient;Data;Data Analyses;Data Collection;data enclave;data harmonization;data platform;Data Science;Data Set;Electronic Health Record;Environment;genetic variant;Genomics;Health;Image;Informatics;Information Technology;Ingestion;meetings;multimodal data;National Center for Advancing Translational Sciences;open source;open source tool;operation;Pathology;Privacy;Productivity;programs;protective factors;Pythons;Radiology Specialty;Research;Research Personnel;Risk Factors;Scientist;Secure;Security;Services;Statistical Data Interpretation;synthetic data;tool;United States;United States National Institutes of Health;Viral;virtual;Visualization;Work

PROJECT_TITLE: BO 011 - UNA OPERATIONS AND TECHNICAL SUPPORT SERVICES (OTSS)


PROJECT_TERMS: analytical tool;Area;Clinical and Translational Science Awards;Clinical Research;cloud based;cohort;Collaborations;Communities;Complex Analysis;Contracts;COVID-19;COVID-19 patient;Data;Data Analyses;Data Collection;data enclave;data harmonization;data platform;Data Science;Data Set;Electronic Health Record;Environment;genetic variant;Genomics;Health;Image;Informatics;Information Technology;Ingestion;meetings;multimodal data;National Center for Advancing Translational Sciences;open source;open source tool;Pathology;Privacy;Productivity;programs;protective factors;Pythons;Radiology Specialty;Research;Research Personnel;Risk Factors;Scientist;Secure;Security;Services;Statistical Data Interpretation;synthetic data;tool;United States;United States National Institutes of Health;Viral;virtual;Visualization;Work

PROJECT_TITLE: TO1 - STSS PROGRAM SUPPORT 1.0


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Rare Diseases

PROJECT_TERMS: analytical tool;cloud based;Environment;Information Systems;open source;Productivity;Rare Diseases;Services;tool


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: analytical tool;Architecture;cloud based;Environment;Extramural Activities;National Center for Advancing Translational Sciences;open source;Productivity;programs;Security;Services;tool;Trust

PROJECT_TITLE: STSS PROGRAM SUPPORT 5.0


PROJECT_TERMS: analytical tool;Architecture;cloud based;Environment;Extramural Activities;National Center for Advancing Translational Sciences;open source;Productivity;programs;Security;Services;Technology;tool;Trust


NIH_SPENDING_CATS: Clinical Research;Health Services;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: EVERSANA LIFE SCIENCE SERVICES LLC

ORG_STATE: WI

PI_NAMEs: RUSSO, PIERANTONIO  (contact)

PROJECT_TERMS: Healthcare Systems;Patients;programs;Rare Diseases;Research Support;Services

PROJECT_TITLE: CUSTOMER VALUE PARTNERS, INC.:1213137 [24-000129]


PI_NAMEs: NATHAN, RAMAA  (contact)

PROJECT_TERMS: Biological Sciences;Healthcare Systems;Patients;programs;Rare Diseases;Research Support;Services

PROJECT_TITLE: EVERSANA LIFE SCIENCE SERVICES LLC:1466808 [24-007681]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Immunization;Myasthenia Gravis;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: COLUMBIA

ORG_NAME: A AND G PHARMACEUTICAL, INC.

PI_NAMEs: KOSOWSKY, AKIVA  (contact)

PROJECT_TERMS: Cell Line;Congenital Myasthenic Syndromes;drug candidate;Drug Kinetics;gene therapy;Generations;Human;immunogenicity;method development;Monoclonal Antibodies;National Center for Advancing Translational Sciences;polyclonal antibody;Toxicokinetics

PROJECT_TITLE: TASK ORDER 7 - DOK7


ORG_CITY: WESTBURY

ORG_STATE: NY

PI_NAMEs: TAYLOR, ANDREW  (contact)

PROJECT_TERMS: Services;tumor

PROJECT_TITLE: TRANSPORTER SUBSTRATE ASSESSMENT STUDY, SERVICES


ACTIVITY: ZIA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: SPARKS, RACHEL  (contact)

PROJECT_TERMS: accurate diagnosis;Affect;Cell Line;Cells;Clinical;Clinical Data;Clinical Management;clinically actionable;clinically significant;cytokine;Data;data integration;Defect;Diagnosis;Diagnostic;diagnostic strategy;diagnostic tool;Disease;disease classification;disease diagnosis;Etiology;Evaluation;experience;Frequencies;Future;Gene Expression;Generations;genetic disorder diagnosis;Genetic Predisposition to Disease;Goals;Guidelines;Immune;Immune system;Immune System Diseases;immunodeficiency;Immunologics;Immunology;improved;Individual;Knowledge;Malignant Neoplasms;Measures;Medical;Modeling;Molecular;Morbidity - disease rate;mortality;multiple data types;new technology;novel;Organism;Pathologic;Patients;personalized approach;Phenotype;Process;Proteins;Research;RNA;sample collection;System;Systems Biology;Techniques;technology development;therapeutic target;Transcript;transcriptome sequencing;Work

PROJECT_TITLE: Sample collection for systems evaluation of patients with unknown or incompletely characterized immune defects


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PROJECT_TERMS: Agreement;Artificial Intelligence;Clinical Pathology;Data;Development;Environmental Health;Gene Expression;GENIE;health data;Histopathology;Informatics;Laboratories;Methods;Modeling;models and simulation;National Institute of Environmental Health Sciences;Organ;Public Health;research and development;Research Support;Resources;Software Tools;Tissues;Toxicology

PROJECT_TITLE: Development of Artificial Intelligence to Support the Division of Translational Toxicology


PROJECT_TITLE: INTERAGENCY AGREEMENT Between NATIONAL INSTITUTES OF HEALTH NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES and US FOOD AND DRUG ADMINISTRATION NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Alzheimer’s Disease (AD) poses an increasingly large public health burden. By providing new insights into the role of neuroinflammation in AD, this study will provide the foundation for future advances in prognostication and targeted anti-inflammatory therapies for this devastating disease.

PI_NAMEs: BUTLER, TRACY A.;GUPTA, AJAY  (contact);RAJ, ASHISH

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affinity;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;animal data;Anti-Inflammatory Agents;Atrophic;Biological;Biological Markers;Biological Models;Brain;brain magnetic resonance imaging;Cerebrospinal Fluid;Clinical;clinical application;clinical heterogeneity;Cognition;Cognitive;Computer Models;Dementia;density;Diagnosis;Diagnostic;Diffusion;Disease;disease model;disease phenotype;Disease Progression;Education;Etiology;follow-up;Foundations;Functional disorder;Future;Generations;genetic risk factor;glial activation;Glucose;Goals;Human;Image;imaging study;in vivo;Inflammation;Inflammatory;inflammatory marker;insight;Investigation;Kinetics;Laboratories;Ligands;Linear Models;Longitudinal cohort;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;mathematical model;Measures;Mediating;Mediation;Microglia;model design;Modeling;Modernization;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;neurotransmission;novel;older adult;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Positron-Emission Tomography;predictive modeling;predictive test;prognostication;Property;Protocols documentation;Public Health;Race;Research;Role;Science;Senile Plaques;Series;Serum;sex;Signal Transduction;spatiotemporal;Specificity;Speed;Statistical Models;systemic inflammatory response;tau aggregation;tau interaction;tau mutation;tau Proteins;Testing;Time;tractography;transmission process;TREM2 gene;Visit

PROJECT_TITLE: Understanding the dynamic interactions between tau pathology and microgliamediated inflammation in Alzheimer's Disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PI_NAMEs: RYBICKI, BENJAMIN  (contact)

PROJECT_TITLE: CONNECT TASK ORDER 8


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PI_NAMEs: FIEGLESON, HEATHER  (contact)


ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PI_NAMEs: CHUN-HUNG, CHAN  (contact)


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: AHSAN, HABIBUL  (contact)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HPV and/or Cervical Cancer Vaccines;Human Genome;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: SAN JOSE

ORG_COUNTRY: COSTA RICA

ORG_FIPS: CS

ORG_NAME: FUNDACION INCIENSA

PI_NAMEs: PORRAS, CAROLINA  (contact)

PROJECT_TERMS: Adult women;Biological Assay;cancer genomics;Certification;cervical cancer prevention;Clinical Trials;Collaborations;Contractor;Contracts;Costa Rica;Dose;Evaluation;Genotype;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;International;Laboratories;Laboratory Research;Measures;next generation sequencing;Participant;Prevention;primary endpoint;Procedures;quality assurance;Quality Control;Reporting;Sampling;Standardization;Testing;Training;vaccine trial;Validation;young adult

PROJECT_TITLE: Laboratory testing of biospecimens collected from participants of the NCI’s HPV Vaccine studies.


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

PI_NAMEs: DAY, ROBERT  (contact)

PROJECT_TERMS: Genomics;Precision Health

PROJECT_TITLE: ROUNDTABLE ON GENOMICS AND PRECISION HEALTH


NIH_SPENDING_CATS: Clinical Research

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PROJECT_TITLE: POPULATION ASSESSMENT OF TOBACCO AND HEALTH (PATH) STUDY PERIOD OF PERFORMANCE: 02/01/2024 - 01/31/2029


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: This research is important because it aims to better understand how heart cells (cardiomyocytes) mature, which is crucial for maintaining healthy heart function throughout life. Defects in this process can lead to severe cardiovascular diseases (CVDs), the leading cause of death globally. Advancing our knowledge in this area could improve treatments for congenital heart defects, adult heart diseases, and efforts to regenerate heart tissue.

PI_NAMEs: SHI, WEI  (contact)

PROJECT_TERMS: Adult;Area;Binding;Blood Vessels;Calcium;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;Catalytic Domain;Cause of Death;Cell Cycle Arrest;CHD4 gene;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;clinical application;cohort;Complex;congenital heart abnormality;Congenital Heart Defects;Data;Deacetylase;Defect;DNA Binding;DNA-Binding Proteins;Embryo;Embryonic Heart;Ensure;Enzymes;Exhibits;fetal;Foundations;Gene Expression;gene regulatory network;Genes;Genetic Transcription;genomic locus;Glycolysis;Heart;heart cell;Heart Diseases;Heart failure;heart function;human pluripotent stem cell;improved;in vivo;Knowledge;Lead;Life;Metabolism;Missense Mutation;Molecular;mortality;mutant;Mutation;Natural regeneration;Nebraska;neonatal mice;NFIA gene;novel therapeutic intervention;Nucleosomes;Oxidative Phosphorylation;Phenotype;Pluripotent Stem Cells;postnatal;proband;Process;programs;Proteins;recruit;Regenerative Medicine;Research;Role;Time;Tissues;transcription factor;Transcriptional Regulation;Ventricular Septal Defects

PROJECT_TITLE: Gene Regulatory Networks in Postnatal Cardiomyocyte Maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


PROJECT_TERMS: Allogenic;Award;Back;bench to bedside;Clinical;Clinical Investigator;Clinical Research;Collaborations;Community Health;education research;Extramural Activities;Funding Opportunities;Lung Diseases;outreach;programs;Research Project Grants;Scientist;Services;Stem cell transplant;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: INTER-AGENCY SERVICE (NIH)


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Lung

PROJECT_TERMS: Allogenic;Anus;Award;Back;bench to bedside;Clinical;Clinical Investigator;Clinical Research;Collaborations;Community Health;COVID-19;Dysplasia;education research;Eosinophilic Esophagitis;eosinophilic inflammation;Extramural Activities;Funding Opportunities;Hematopoiesis;HIV;Human Papillomavirus;Immunity;Lung Diseases;outreach;Population;programs;Research Project Grants;Resources;Scientist;screening;senescence;Services;Stem cell transplant;T-Lymphocyte;transgender women;Translational Research;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Acute;Award;Back;bench to bedside;Clinical;Clinical Investigator;Clinical Research;Collaborations;Community Health;COVID-19;Degos disease;Development;education research;Endothelium;Extramural Activities;Funding Opportunities;gene therapy;Immune;in vivo;inhibitor;outreach;programs;Research Project Grants;Scientist;senescence;Services;Sickle Cell Anemia;Translational Research;United States National Institutes of Health;Vascular Diseases;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: Portland

ORG_NAME: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER

ORG_STATE: OR

PHR: PROJECT NARRATIVE Inherited retinal degenerations affect ~120,000 people in the USA and ~2.5 million world-wide. This project aims to validate lipid nanoparticle gene editing platforms in the retina of a large animal model, the non-human primate. These platforms will be used for the treatment of retinal degeneration.

PI_NAMEs: RYALS, RENEE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Optimizing lipid nanoparticles for retinal gene editing in the NHP

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Nutrition;Rare Diseases

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: Agreement;Animal Model;ChIP-on-chip;chromatin immunoprecipitation;Code;Development;dietary;Disease susceptibility;DNA Microarray Chip;Epigenetic Process;epigenomics;Etiology;Evaluation;Exhibits;Fatty Liver;fecal microbiota;Female;Fibrosis;Genetic Determinism;genome-wide;Genomics;Goals;Hepatic;High Fat Diet;Human;Individual;Leukocytes;Link;Liver;liver injury;male;Malignant neoplasm of liver;Methodology;MicroRNAs;Modeling;Molecular;molecular marker;Molecular Target;Mouse Strains;Mus;next generation sequencing;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Pathogenesis;Pathway interactions;Phenotype;Plasma;Population;Population Heterogeneity;Predisposition;Process;protein expression;Quantitative Reverse Transcriptase PCR;Resistance;Role;Sampling;Severity of illness;Testing;Time;Untranslated RNA;western diet;whole genome

PROJECT_TITLE: Genomic and genetic determinants of the susceptibility to non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver cancer


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Networking and Information Technology R&D (NITRD);Prevention

PROJECT_TERMS: anti-cancer research;Apache;Bioinformatics;bioinformatics network;Biological Markers;biomarker validation;Biomedical Research;cancer biomarkers;Cancer Biomarkers Research Group;Cancer Detection;Collaborations;Communities;Complex;Computer software;Data;data archive;data management;data resource;Data Set;data sharing;Development;Discipline;Disease;distributed data;Early Detection Research Network;effective therapy;Environment;Foundations;Funding;Informatics;informatics tool;information model;Information Systems;Knowledge;knowledgebase;Laboratories;Laboratory Research;Machine Learning;Malignant Neoplasms;Metadata;Mission;Morphologic artifacts;network informatics;open source;Planet Earth;programs;Protocols documentation;Publications;Research;Research Personnel;Science;Semantics;System;Technology;United States National Aeronautics and Space Administration;Validation;validation studies;virtual;Visualization;Work

PROJECT_TITLE: NASA, JPL Bioinformatics for Cancer Detection


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Tracheal intubation (Tl) of critically ill children presenting to the emergency department after trauma, such as motor  vehicle collisions, falls, and penetrating injury, is a lifesaving but challenging procedure. Quality improvement efforts  using airway management checklists have improved outcomes for children undergoing Tl in pediatric and neonatal  intensive care units, but no such checklist has been implemented in the pediatric emergency department setting. This  study aims to pilot and refine a set of implementation strategies to implement a novel pre-intubation checklist at a  broad range of PEDs, which will be studied further in the future to evaluate its effect on clinical outcomes

PI_NAMEs: WING, ROBYN  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;Adverse event;Caring;Centers of Research Excellence;Child;Childhood;Clinical;clinical care;cohort;Consensus;Critically ill children;Data;Data Coordinating Center;dissemination trial;Emergency Medicine;Emergency Situation;Event;evidence base;Exploration, Preparation, Implementation, and Sustainment;falls;feasibility trial;Feedback;Focus Groups;Future;Hospitals;implementation strategy;implementation trial;improved;improved outcome;Infrastructure;Injury;Intratracheal Intubation;Intubation;Life;Measures;Methods;multidisciplinary;Neonatal Intensive Care Units;novel;Outcome;Patients;pediatric emergency;pediatric trauma;Penetration;Procedures;Process;prospective;Provider;Recommendation;Registries;Reporting;Research;Rhode Island;Surveys;Time;Trauma;trauma centers;Vehicle crash

PROJECT_TITLE: Feasibility Trial of an Implementation Bundle for the National Emergency Airway Registry for Pediatric Emergency Medicine (NEAR4PEM) Pre-Intubation Checklist


ORG_CITY: MIDDLETON

ORG_NAME: BIOTEAM, INC.

PROJECT_TITLE: NIMHD SCHARE RESEARCH PLATFORM:SCHARE-TERRA-GDE


ORG_CITY: DENVER

ORG_NAME: PALANTIR TECHNOLOGIES, INC.

ORG_STATE: CO

PROJECT_TITLE: AIM-AHEAD DATA SCIENCE TRAINING ENCLAVE


ORG_CITY: NORTH BETHESDA

ORG_NAME: AXLE INFORMATICS, LLC

PROJECT_TITLE: AIM-AHEAD DATA SCIENCE TRAINING SERVICES: NCATS & AIM-AHEAD ADVANCED DATA ANALYSIS TRAINING PROGRAM (ADATP)


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Address;anti-cancer research;Award;Data;Data Commons;experience;improved;Modeling;Participant;Prize;Process;Readiness;Recommendation;United States National Institutes of Health

PROJECT_TITLE: NCI CANCER RESEARCH DATA COMMONS CRDC AI DATA READINESS CHALLENGE AWARD INITIAL OBLIG


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PROJECT_TERMS: Address;Affect;Algorithms;Biomedical Technology;Development;digital;digital twin;Engineering;Evaluation;Foundations;Goals;Healthcare;Human;in silico;Interdisciplinary Study;Mathematics;Medical Device;method development;Modeling;programs;Research Project Grants;synthetic data;technological innovation

PROJECT_TITLE: Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation


NIH_SPENDING_CATS: Coronaviruses

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PROJECT_TITLE: INNOVATION FUNNEL FOR COVID19 - COMMERCIALIZATION CENTER


ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This grant aims to understand the molecular and regulatory details of how a novel and conserved subfamily of heme-binding proteins responds to glyoxal-related toxicity. The data derived from this work is expected to shed light on the understudied area of glyoxal induced cellular stress, and how it regulates cellular metabolic changes and disease.

PI_NAMEs: ULIJASZ, ANDREW T (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: A novel family of conserved glyoxal toxicity response proteins.

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


PROJECT_TITLE: RADX INNOVATION FUNNEL FOR COVID-19 - AWARD MANAGEMENT


ORG_STATE: DC

PROJECT_TERMS: Genomics;National Center for Advancing Translational Sciences;Precision Health


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: MCCORMACK, JENNIFER  (contact)

PROJECT_TERMS: Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Pharmacotherapy;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: OPTIMIZING RETENTION, DURATION AND DISCONTINUATION STRATEGIES FOR OPIOID USE DISORDER PHARMACOTHERAPY (CTN-0100). AUGUST 15, 2024 TO MARCH 31, 2028. N01DA-22-2253. TASK ORDER NO. 75N95024F00007 (TO23)


PI_NAMEs: JELSTROM, EVE  (contact)

PROJECT_TERMS: Clinical;Contracts;Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Pharmacotherapy;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: CTN'S CLINICAL COORDINATING CENTER CONTRACT. CTN STUDY, OPTIMIZING RETENTION, DURATION AND DISCONTINUATION STRATEGIES FOR OPIOID USE DISORDER PHARMACOTHERAPY (CTN-0100). POP: 8/15/24 - 4/2/28