NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TORONTO

ORG_NAME: UNIVERSITY OF TORONTO

ORG_ZIPCODE: M5S 1S8

PHR: Project Narrative This project uses linked survey and administrative data to understand the impact of multidimensional and longitudinal measures of integration into U.S. society on older immigrants’ physical and cognitive health. It also leverages a cross-national comparison to uncover the role of federal institutional designs in shaping the integration-health link. The outcomes of this project will help uncover why immigrants experience accelerated health declines over the life course, as well as identify specific areas for policy intervention to reduce racial/ethnic health disparities among immigrants.

PI_NAMEs: YE, LEAFIA ZI (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Acculturation;Adopted;Affect;Age;Area;Asian;Attention;Black race;Canada;Censuses;Cognitive;Color;Community Health;Country;Cultural Diversity;Data;Data Sources;Databases;Demographer;design;Dimensions;Economic Conditions;economic outcome;Economics;Elderly;ethnic health disparity;ethnic minority;Ethnic Population;experience;Exposure to;Face;Familiarity;Family;Geographic Locations;Health;Health and Retirement Study;health care availability;health disparity;Health Policy;Healthcare;Healthcare Systems;Hispanic;Immigrant;Immigration;Impaired cognition;Individual;insight;Institution;Intervention;Investigation;late life;Life;Life Cycle Stages;Linguistics;Link;Literature;Longitudinal Surveys;Measures;member;Memory;Methodology;middle age;minority communities;Native-Born;Neighborhoods;novel;Occupations;older adult;Outcome;people of color;physical conditioning;Physical Function;physically handicapped;Policies;Population;preference;Process;programs;Public Health;Race;racial difference;racial disparity;racial health disparity;racial minority;racial population;racism;Reduce health disparities;Research;Resources;Respondent;Role;Sampling;Shapes;social;Social Conditions;Societies;socioeconomics;sociologist;Speed;stressor;Surveys;Testing;theories;Time;United States Social Security Administration

PROJECT_TITLE: Immigrant Integration and Health: Multidimensional and Cross-National Analyses Over the Life Course

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Cost Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Multidrug-resistant tuberculosis (MDR-TB) is a leading cause of mortality due to antimicrobial resistance and the transmission of MDR-TB threatens the effective control of TB, especially in countries of the former Soviet Union. There is a gap in our understanding of how specific lineages of M. tuberculosis acquire resistance and maintain high reproductive fitness, allowing them to transmit and cause disease among susceptible hosts. We propose to study of the evolution, transmission, and control of competing lineages of MDR-TB in the Republic of Moldova by applying innovative phylogenetic, statistical, and transmission dynamic modeling approaches to M. tuberculosis isolates and epidemiological data collected since 2010.

PI_NAMEs: COHEN, THEODORE H (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;analytical tool;Antimicrobial Resistance;Antitubercular Agents;Antitubercular Antibiotics;Asia;biobank;Clinical;Collection;cost;cost effective intervention;cost effectiveness;Cost Effectiveness Analysis;Country;Data;Diagnosis;Disease;Drug Controls;Drug resistance;Drug resistance in tuberculosis;Ensure;Epidemic;epidemiologic data;epidemiology study;Europe;Evolution;Genetic;Genetic Determinism;genomic epidemiology;Genomics;Geographic Distribution;Geographic Locations;Growth;Health;Health Policy;Incidence;indexing;Individual;innovation;Integration Host Factors;Interruption;Intervention;Investigation;isoniazid;Laboratories;Methods;Modeling;Moldova;mortality;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Multiple drug resistant Mycobacteria Tuberculosis;Mutation;Mycobacterium tuberculosis;novel;Paint;Patients;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Predisposition;Prevalence;Probability;prospective;Public Health;public health intervention;rapid growth;reproductive;reproductive fitness;Research;Research Personnel;Resistance;Resource Allocation;resource guides;respiratory;Rest;Rifampicin resistance;Rifampin;Speed;success;Testing;therapy design;Time;transmission blocking;transmission process;Tuberculosis;tuberculosis treatment;Uncertainty;USSR;whole genome;willingness to pay;Work;World Health Organization

PROJECT_TITLE: Evolution, transmission, and control of drug-resistant tuberculosis

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PhysioNet, the Research Resource for Complex Physiological Signals, maintains the world's largest, most comprehensive and most widely used repository of physiological data and data analysis software, making them freely available to the research community. PhysioNet is a proven enabler and accelerator of innovative biomedical research through its unique role in providing data and other resources that otherwise would be inaccessible.

PI_NAMEs: GOLDBERGER, ARY LOUIS (contact);MARK, ROGER GREENWOOD

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Achievement;Address;analytical method;Arrhythmia;Artificial Intelligence;Atrial Fibrillation;Award;Benchmarking;Biological Markers;Biomedical Research;Cardiopulmonary;Clinical;clinical care;Clinical Data;cloud based;Collection;Coma;Communities;Complex;Computer software;Computing Methodologies;Coupling;Critical Care;Data;Data Analyses;data archive;Data Collection;data exploration;data format;data interoperability;Data Reporting;data repository;data resource;data reuse;Data Set;Databases;Detection;Development;Disease;diverse data;Doctor of Philosophy;Documentation;Education;Educational Status;Electrocardiogram;Fatigue;fetal;Functional disorder;Funding;Goals;Health;Health Status;Heart Arrest;hemodynamics;high school;Image;Improve Access;improved;Industry;innovation;insight;instrument;instrumentation;Intensive Care;Intensive Care Units;interest;International;Label;Lead;Legal patent;Life;machine learning model;Medical;Metadata;Methodology;Methods;Modeling;Monitor;National Institute of Biomedical Imaging and Bioengineering;neurological recovery;novel;open source;Patients;Physiological;prediction algorithm;Prize;Process;programs;Publications;Publishing;repository;Research;Research Personnel;Resolution;Resources;response;risk stratification;Role;Sepsis;Services;shared repository;Signal Transduction;Site;Sleep Apnea Syndromes;Students;Technology;technology development;Testing;Time;time interval;Time Series Analysis;tool;United States National Institutes of Health;Visualization software

PROJECT_TITLE: Research Resource for Complex Physiologic Signals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-N (90)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The proposed research is relevant to public health because it aims to create information that is necessary for the development of means to correct intestinal barrier defects, i.e., reverse “leaky gut,” in inflammatory bowel disease. Such barrier-restoring agents have the potential to be a significant advance in treatment of inflammatory bowel disease and other intestinal and systemic disorders associated with gut barrier loss. Thus, the proposed studies are highly-relevant to the NIDDK mission of supporting research that will improve health and quality of life for those with digestive diseases as well as the NIH mission of seeking and applying fundamental knowledge that will enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: TURNER, JERROLD R. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Actomyosin;Animal Disease Models;barrier to testing;Binding;Binding Proteins;Biopsy;Calmodulin;Celiac Disease;Cells;Characteristics;Chronic;Clinic;Clinical;Cytoskeleton;Data;Defect;Development;Diabetes Mellitus;Digestive System Disorders;disability;Disease;disease model;Disease Progression;Disease remission;druggable target;Endocytosis;Enterocolitis;Epithelium;Food Hypersensitivity;Foundations;Functional disorder;gastrointestinal;Goals;Health;Human;human disease;human subject;Immune;improved;In Vitro;in vivo;in vivo Model;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;insight;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Kinetics;Knock-out;Knockout Mice;Knowledge;Leaky Gut;Life;Link;Mediating;Mediator;Metabolic syndrome;Mission;Modeling;Molecular;mortality;mouse model;Mus;Mutate;myosin light chain 2;Myosin Light Chain Kinase;National Institute of Diabetes and Digestive and Kidney Diseases;Organoids;Outcome;Pathogenesis;Patients;Peptidylprolyl Isomerase;Permeability;Pharmaceutical Preparations;pharmacologic;Phosphorylation;pre-clinical;pre-clinical assessment;preclinical efficacy;prevent;Prevention;Process;programs;protein expression;Protein Isoforms;Proteins;Public Health;Publishing;Quality of life;recruit;Regulation;Reporting;Research;research clinical testing;Research Support;restoration;RNA Splicing;Role;Severity of illness;Signal Transduction;Site;small molecule;stem cell model;Stimulus;Structure;targeted agent;Testing;Therapeutic;therapeutic target;Tight Junctions;TNF gene;Transgenic Organisms;Translations;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Our overall objective is to fully understand how to take high quality muscle signals from implanted electrodes and predict the position and movement of the hand and fingers. This is very important for people with upper limb amputations for controlling their prosthetic hand, but could also impact our understanding of how to control other complex robotic systems.

PI_NAMEs: CHESTEK, CYNTHIA ANNE (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Activities of Daily Living;Address;Algorithms;Amputees;Architecture;Biological Process;biomechanical model;Biomechanics;Brain;brain machine interface;Calibration;Classification;classification algorithm;Clinical;clinical care;cognitive load;comparison control;Complex;Data;deep learning;Elbow;electric impedance;Electrodes;Electromyography;Elements;Environment;experimental study;Fascicle;finger movement;Fingers;Freedom;Frustration;Goals;grasp;Hand;Human;human subject;Implant;Implanted Electrodes;improved;Individual;kinematics;large datasets;Learning;Life;limb amputation;Methods;Monkeys;Motor;motor control;Movement;Muscle;muscle grafts;Natural regeneration;Nerve;neural network;neural network architecture;Neurosciences;neurotransmission;Noise;nonhuman primate;novel;Operative Surgical Procedures;Pattern Recognition;Performance;Peripheral Nerves;Persons;Positioning Attribute;Primates;Prosthesis;prosthesis control;prosthesis wearer;prosthetic hand;Rattus;regenerative;reinnervation;Residual state;revascularization;robotic system;Running;segregation;Signal Transduction;Speed;standard of care;Surface;System;Task Performances;Techniques;Technology;Testing;Thumb structure;Time;training data;Upper Extremity;Work;Wrist

PROJECT_TITLE: Improving hand kinematic predictions from implanted EMG in humans and monkeys

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on inhibiting a progenitor cell determinant to therapeutically restore terminal maturation as a means of skin cancer prevention. By understanding how normal cells remain undifferentiated, we ultimately hope to reverse this process in cancer cells, thereby limiting their capacity for unregulated proliferation. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: LEE, CAROLYN S. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Ablation;Affinity Chromatography;Animal Model;Antigen Presentation;Behavior Control;Biological Assay;biophysical techniques;cancer cell;carcinogenesis;Carcinoma;Carcinoma in Situ;cell behavior;Cells;Clinical Research;Clinical Trials;Country;Data;design;Development;disability;Disease;Down-Regulation;Dysplasia;efficacy evaluation;Engraftment;epidermal stem cell;Epidermis;Event;experimental study;Future;Genetic;Genitourinary system;Goals;Growth;Homeostasis;Human;Immune;in vivo;Incidence;inhibitor;inhibitor therapy;innovation;insight;keratinocyte;Kinetics;Knowledge;Lesion;Light;Malignant - descriptor;Malignant Keratinocyte;Malignant Neoplasms;Maps;Mission;Molecular;Molecular Target;Mus;mutant;Nature;Neoplasms;neoplastic cell;neural;Normal Cell;novel;novel therapeutic intervention;Organoids;Outcome;pharmacologic;Phosphorylation;Phosphotransferases;Populations at Risk;preclinical study;Preclinical Testing;premalignant;Prevention;Process;progenitor;Proliferating;Protein Tyrosine Kinase;Public Health;Receptor Protein-Tyrosine Kinases;Regulation;Research;Secondary Prevention;Signal Transduction;Skin;Skin Cancer;skin cancer prevention;Skin Carcinogenesis;skin squamous cell carcinoma;Specific qualifier value;Specimen;stem cells;sun damage;Testing;Therapeutic;therapeutic development;therapeutically effective;Tissues;Transfection;Treatment Efficacy;tumor;tumor progression;Tumor stage;tumor-immune system interactions;tumorigenesis;ubiquitin-protein ligase;ultraviolet;Undifferentiated;United States National Institutes of Health;UV carcinogenesis;UV induced;Xenograft procedure

PROJECT_TITLE: Kinase Signaling in Epidermal Homeostasis and Early Neoplasia

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Mutations in DNA repair genes called BRCA1 and 2 increase pre-disposition to multiple cancers. Currently BRCA mutant cancer cells are treated with inhibitors of Poly (ADP-ribose) polymerase (PARP) enzymes; however, this treatment strategy has multiple limitations. In this proposal, we will develop a framework to overcome the clinical limitations of PARP inhibitors and hence provide an effective strategy for the treatment of BRCA mutant cancers.

PI_NAMEs: VERMA, PRIYANKA  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;base;Base Excision Repairs;Biochemical;Biological Assay;Biological Markers;Biological Models;Biology;BRCA deficient;brca gene;BRCA mutations;BRCA1 gene;cancer cell;Cancer Etiology;Cell Proliferation;Cells;Cellular Assay;Chemoresistance;Chromatin;chromatin remodeling;chromosome fusion;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Coupled;Data;DNA biosynthesis;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA replication fork;dosage;Double Strand Break Repair;Electron Microscopy;Engineering;Enhancing Lesion;Enzymes;Exhibits;experimental study;fitness;Foundations;Frequencies;Generations;Genetic;Genetic Complementation Test;Goals;homologous recombination;Hypersensitivity;improved;improved outcome;In Vitro;inhibitor;inhibitor therapy;insight;Knowledge;Label;Lesion;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;Molecular;mutant;Mutation;nanomolar;Normal Cell;novel strategies;Nucleosomes;Patients;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Predisposition;Protein Biochemistry;Publishing;reconstitution;Regimen;repair enzyme;repaired;Reporting;Resistance;response;Role;side effect;single molecule;Site;Slide;success;Susceptibility Gene;Therapeutic;therapeutically effective;Toxic effect;treatment response;treatment strategy;Xenograft Model

PROJECT_TITLE: Targeting base damage repair in BRCA-mutant cancers

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Metastases form in a wide range of target organs that vary not only in their chemical composition but also in their mechanical rigidity. We have found that patrolling immune cells preferentially engage and destroy stiffer cancer cells. Our proposed studies will investigate if and how the rigidity of the metastatic microenvironment influences the stiffness dependent killing of cancer cells and, by extension, whether the interplay between tissue mechanics and immune function effectively dictates where metastases grow.

PI_NAMEs: HUSE, MORGAN A (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Affect;Antibodies;Biochemical Process;Biological Models;biomarker identification;Biomechanics;biophysical properties;biophysical techniques;Biophysics;bone;bone invasion;Brain;cancer cell;cancer immunotherapy;Cell Separation;Cell-Mediated Cytolysis;Cells;Chemicals;Cytoskeleton;cytotoxic;Cytotoxic T-Lymphocytes;Development;Devices;Environment;Genes;Genetic;Growth;Health;Histologic;Histology;Human;Human Resources;Immune;immune checkpoint blockade;immune function;Immune system;Immunity;Immunologic Surveillance;Implant;improved;In Vitro;in vivo;innovation;innovative technologies;interdisciplinary approach;interest;Invaded;Knowledge;Liver;Locales;Lung;Lymphocyte;Lymphocyte Activation;Measures;mechanical properties;Mechanics;Mediating;Metastatic Neoplasm to the Bone;Methods;Mission;Molecular;mouse model;multidisciplinary;Mus;Muscle;Natural Killer Cells;neoplasm immunotherapy;Neoplasm Metastasis;novel;novel strategies;Organ;osteopontin;Pathway interactions;Patients;physical process;physical property;Play;polyacrylamide;Positioning Attribute;preference;pressure;Process;Proteoglycan;receptor;Regulation;Research;Role;scaffold;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Surface;T-Lymphocyte and Natural Killer Cell;Technology;therapeutic development;Tissues;transcriptomics;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: A Mechanoimmunological Basis for Metastatic Site Preference

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROGRAM NARRATIVE In this revised U01 application for the “Alzheimer’s Disease Sequencing Project (ADSP) Follow-Up Study 2.0: The Diverse Population Initiative” (PAR-21-212), our overall goals are to: (i) contribute nearly 20,000 GWAS and 5000 whole genome sequences to ADSP from participants of the “Estudio de la Salud de las Maestras” (Mexican Teachers Cohort), and (ii) detect novel genetic drivers of cognitive function in this large, admixed Mexican cohort, in combination with existing ADSP cohorts.

PI_NAMEs: GRODSTEIN, FRANCINE  (contact);LAJOUS, MARTIN

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;Admixture;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Amerindian;ancestry analysis;Autopsy;Blood specimen;causal variant;Central American;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Cohort Studies;Collaborations;Complement;Data;data harmonization;data hub;Dementia;design;Diagnosis;DNA;Ethnic Population;Evaluation;experience;follow-up;Follow-Up Studies;Genes;Genetic;Genetic Determinism;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomics;Genotype;Goals;Health;heteroplasmy;Hispanic;Hispanic Populations;human old age (65+);Impaired cognition;improved;Indigenous;Latinx;Latinx population;Length;Linkage Disequilibrium;Maps;Measures;men;Mexican;Mexican Americans;Mexico;Mitochondrial DNA;neuropathology;Not Hispanic or Latino;novel;Other Genetics;Participant;Pathologic;Pathway interactions;Pattern;Phenotype;Population;Population Heterogeneity;Process;recruit;repository;Research;Research Personnel;Research Support;Resource Sharing;Sampling;screening;Secondary to;social health determinants;South American;Specimen;teacher;telomere;Testing;Time;trait;Universities;Variant;whole genome;Woman;Women's cohort

PROJECT_TITLE: Mexican Teachers Cohort Study: Genetics and Cognitive Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M4)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Neuroblastoma is a common pediatric cancer that is difficult to effectively treat, especially as it frequently is detected after already metastasizing from a primary site. The norepinephrine transporter (NET) and somatostatin receptor subtype 2 (SSTR2) are well-known biomarkers for neuroblastoma care, to which radiotherapies have been applied with mixed results. In this application we develop a new class of high linear energy transfer therapies that exploit the high expression of these biomarkers for a novel and definitive combination therapy. We evaluate the efficacy, localized tumor control and cellular-genomic effects of this treatment in cultured cell lines and in advanced patient derived models of disease, and compare with conventional treatments. This information will be used to advance these potent agents to improve neuroblastoma patient care.

PI_NAMEs: HUANG, FREDERICK SZUJUEI;ZHANG, HANWEN  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Ablation;absorption;Address;Affect;Affinity;Aftercare;Alpha Particles;analog;antagonist;anti-cancer;Autoradiography;Beta Particle;Binding;Biodistribution;Biological;Biological Markers;biomarker validation;cancer cell;cancer heterogeneity;Caring;Cell Line;Cell Survival;Cephalic;chelation;chemical stability;Child;Clinical Trials;Combined Modality Therapy;Compensation;conventional therapy;cytotoxicity;Data;Deposition;Diagnosis;differential expression;digital;Disease;disease model;Distant;DNA Damage;DNA Repair;Dose;effective therapy;efficacy evaluation;Electrons;Failure;FDA approved;Fluorescence Microscopy;genomic profiles;Genomics;Goals;Guanidines;high risk;Image;improved;in vivo;Incidence;individualized medicine;infancy;Investigation;Kinetics;Length;Lesion;Ligands;Linear Energy Transfer;Malignant Childhood Neoplasm;Malignant Neoplasms;metaiodobenzylguanidine;Microscopic;Microscopy;Modeling;Molecular;molecular imaging;Monitor;Mus;Neuroblastoma;neuroblastoma cell;Neuroendocrine Therapy;Neuroendocrine Tumors;Neurosecretory Systems;next generation;noradrenaline transporter;Norepinephrine;novel;Outcome;particle therapy;Patient Care;patient derived xenograft model;Patients;Pediatric Hospitals;Pediatrics;PET/CT scan;Positron-Emission Tomography;pre-clinical;Radiation therapy;Radionuclide Imaging;Radiopharmaceuticals;Receptor Down-Regulation;receptor downregulation;Receptor Inhibition;Recurrence;Refractory;Regimen;Relapse;Research;Resistance;Resolution;response;Sensitivity and Specificity;single photon emission computed tomography;Site;Solid;Somatostatin Receptor;Staging;Stains;Survival Rate;Targeted Radiotherapy;Testing;Thorium;Tissue Harvesting;Tissues;Translating;Translations;treatment effect;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment strategy;tumor;Tumor Volume;Universities;uptake;Washington;Xenograft procedure

PROJECT_TITLE: COMBINATION HIGH-LET MOLECULAR RADIOTHERAPY OF RELAPSED REFRACTORY NEUROBLASTOMA

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Lung;Nanotechnology

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Colon cancer is the second most common cause of cancer death primarily due to the undruggable mutations to KRAS and subsequent lung metastasis with expected survival of only a few months. This proposal develops approaches for inactivating mutant KRAS via RNA-ligand displaying exosomes loaded with dCas9-HDAC1- gRNA ribonucleoprotein, siRNAs, and chemical drugs individually or in combination. The mechanisms of silencing mutant KRAS genes will be investigated.

PI_NAMEs: GUO, BIN ;GUO, PEIXUAN  (contact);RYCHAHOU, PIOTR

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Antibody Therapy;aptamer;Binding;Biodistribution;cancer cell;Cancer Etiology;cancer therapy;Cells;Cessation of life;Charge;chemical stability;Chemicals;Chimeric Proteins;Code;Colon;Colon Carcinoma;Colorectal Cancer;Complex;CRISPR/Cas technology;Cytosol;Data;density;Density Gradient Centrifugation;design;Disease;Drug Delivery Systems;Drug Kinetics;Drug resistance;Endosomes;Engineering;Epidermal Growth Factor Receptor;Epigenetic Process;epigenome editing;Exclusion;exosome;Foundations;Gene Silencing;Genes;Goals;Guide RNA;HDAC1 gene;Histone Deacetylase;Human;improved;Individual;inhibitor;interdisciplinary approach;KRAS2 gene;Length;Ligands;Liver;Lung;lung metastatic;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Membrane Lipids;metastatic colorectal;Metastatic Neoplasm to the Lung;MicroRNAs;Modeling;Molecular Sieve Chromatography;mutant;Mutation;nanoparticle;nanosized;Nanotechnology;Neoplasm Metastasis;nuclease;Nucleoproteins;Organ;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;Pharmacotherapy;Plasmids;prevent;promoter;protein complex;Proteins;RAS inhibition;ras Proteins;receptor;Recombinant Proteins;Recombinants;Recurrence;Research Personnel;Resistance;response;Ribonucleoproteins;RNA;RNA Interference;RNA Stability;Small Interfering RNA;SN-38;Specificity;Surface;System;TACSTD1 gene;Therapeutic;Thermodynamics;Toxic effect;Treatment Efficacy;tumor;Tumor Suppression;Ultracentrifugation;Xenograft Model;zeta potential

PROJECT_TITLE: Mechanism and approach to inactivate mutant KRAS of lung metastatic colon cancer by RNA-ligand-displaying exosome to co-deliver dCas9--gRNA ribonucleoprotein complex and KRAS siRNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE In this project, we uncover the neural mechanisms of gait and mobility disturbances in preclinical dementia and identify trackable individualized digital biomarkers (from videos). We evaluate the specificity and sensitivity of these gait-based biomarkers and relate those to neural mechanisms and clinical phenotypes. By leveraging these identified markers, we can monitor the disease's progression, potentially minimizing or even replacing the demand for expensive neuropsychological or neuroimaging evaluations.

PI_NAMEs: ADELI, EHSAN  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;age related;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Assessment tool;Biological Markers;biomarker identification;Brain;Brain imaging;Brain region;Calibration;Classification;Clinic;Clinical;clinical phenotype;Cognition;Cognition Disorders;Cognitive;Computer Vision Systems;connectome;consumption measures;cost;Cost Measures;Coupling;Data;Data Collection;Degenerative Disorder;Dementia;Dependence;design;Deterioration;Diagnosis;diagnostic strategy;Diffusion Magnetic Resonance Imaging;digital;Digital biomarker;Disease;disease phenotype;Disease Progression;Education;Educational Background;Equilibrium;Etiology;Evaluation;Functional disorder;Gait;Gait abnormality;Gait speed;Hand;Home;Human;Impaired cognition;Incidence;Individual;instrument;Joints;Language;Link;Magnetic Resonance Imaging;Measurement;Measures;Memory impairment;mild cognitive impairment;Monitor;Motion;Motor;motor disorder;Movement;multimodality;Multivariate Analysis;neural;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologist;neuromechanism;Neuropsychology;Parkinson Disease;Participant;Pathology;Pattern;Phenotype;phenotypic biomarker;Physical Performance;Population;Positioning Attribute;pre-clinical;Research;Rest;Scanning;screening;Screening procedure;Sensitivity and Specificity;Signal Transduction;Signs and Symptoms;Skeleton;smartphone application;Specific qualifier value;Specificity;System;tau-1;Testing;Time;tool;Video Recording;Work

PROJECT_TITLE: Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Myeloid cells (microglia and macrophages) can contribute to both tissue injury and repair in retinal diseases. Efferocytosis, a reparative aspect of myeloid cells by which they “eat” and thereby clean up dead cells, is well- studied in some disease conditions, but whether efferocytosis alleviates retinopathy and how this occurs is poorly understood. This proposal is designed to identify new mechanisms involved in efferocytosis with a potential to develop new therapeutic strategies for retinopathies associated with ischemia and trauma.

PI_NAMEs: FOUDA, ABDELRAHMAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Abbreviations;Antibodies;Apoptotic;Atherosclerosis;Binding;Biological Assay;CD5 Antigens;Cell Death;Cell Surface Receptors;cell type;Cells;clinical development;Coupled;Craniocerebral Trauma;cytokine;Data;design;Development;Diabetic Retinopathy;Disease;Eating;effective therapy;Electroretinography;Enzymes;Event;Exhibits;experimental study;Flow Cytometry;Glaucoma;HDAC3 gene;healing;Image;Immune response;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;injured;Injury;insight;Ischemia;ischemic injury;Knockout Mice;Knowledge;Ligands;Macrophage;Malignant Neoplasms;Mediating;Methods;Microglia;Microscopy;Mission;Molecular;Monitor;mouse model;Myelogenous;Myeloid Cells;nerve damage;neurovascular;neurovascular injury;neutralizing antibody;novel;novel therapeutic intervention;Optic Nerve;Optic Nerve Injuries;Optical Coherence Tomography;Outcome;Pathogenicity;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Phosphatidylserines;Play;preservation;Process;Protein Secretion;PTPNS1 gene;Receptor Protein-Tyrosine Kinases;Recombinants;Research;research study;Research Support;Resistance;Resolution;response;Retina;Retinal Artery Occlusion;Retinal Diseases;retinal ischemia;Retinopathy of Prematurity;Role;screening;SHPS-1 protein;sight restoration;Signal Transduction;Stroke;Surface;Testing;Therapeutic;therapeutic target;tissue injury;tissue repair;TNF gene;transcriptome sequencing;Trauma;Up-Regulation;vein occlusion;Vision Disorders;Visual impairment

PROJECT_TITLE: Retinal neurovascular protection by boosting efferocytosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Heart failure remains a major cause of morbidity and mortality due to both pump failure and lethal arrhythmia. A major barrier to progress in treating these mechanical and electrical problems is the incomplete understanding of cellular mechanisms leading to the disease. In this Project, we will create mathematical models of heart cells and tissues from mice displaying a specific type of heart failure (called heart failure with preserved ejection fraction) to study disease-specific mechanisms, identify druggable targets, and predict implications for treatment of human patients.

PI_NAMEs: MOROTTI, STEFANO  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acceleration;Adopted;Adrenergic Agents;Affect;aging population;Aldosterone;American;Animal Model;Arrhythmia;Biological Markers;Biophysics;Cardiac;Cardiac Myocytes;Cardiovascular system;Cause of Death;Cell model;Cells;Classification;Clinical Trials;Complex;Computer Models;Coupling;Data;db/db mouse;Diabetes Mellitus;Diagnosis;Diffusion;Disease;druggable target;effective therapy;EFRAC;Electrophysiology (science);experience;Failure;Female;Functional disorder;heart cell;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;Hospitalization;Human;Hypertension;In Vitro;Individual;Infusion procedures;insight;leptin receptor;Link;Machine Learning;male;Maps;mathematical model;Mechanics;Medical;Medicine;men;Metabolic dysfunction;model development;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Muscle Cells;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel therapeutic intervention;Obesity;Organ;patient subsets;Patients;Phenotype;Physiological;Physiology;Population;population based;pre-clinical;precision medicine;preservation;Prevalence;Property;Public Health;Pump;Quality of life;Regulation;Risk Factors;Severities;sex;Sex Differences;Signal Transduction;simulation;Subgroup;Survival Rate;Symptoms;Syndrome;synergism;targeted treatment;Techniques;Testing;Therapeutic;therapy development;Tissues;transcriptomics;Translating;Translations;two-dimensional;Update;Validation;Variant;Ventricular;Ventricular Arrhythmia;Woman;Work

PROJECT_TITLE: Phenotype-specific models, mechanisms, and treatment of HFpEF

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE PAX3-FOXO1 and related fusions remain elusive targets for drug therapy despite their clear oncogenic role and adverse prognostic impact in rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood. Our recent genetic and biochemical discoveries offer hope that bi-steric mTORC1 inhibitors capable of suppressing cap-dependent translation can directly target PAX3-FOXO1, but molecular insights into the mechanisms for response to such inhibitors are essential to guide us beyond ongoing phase 1 testing. Here, we will test our hypothesis that bi-steric mTORC1 inhibition prevents translation of PAX3-FOXO1 mRNA and thus ablates its oncogenic program and target mechanisms of resistance that limit efficacy in preclinical models, with the long term goal of enabling biologically grounded combination treatments to cure children affected by this disease.

PI_NAMEs: SABNIS, AMIT J. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 5' Untranslated Regions;Ablation;addiction;Address;Affect;Back;Binding;Biochemical;Biological;Biological Assay;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;CCI-779;Cell Line;Cells;Chemicals;chemotherapy;Child;Childhood;Childhood Rhabdomyosarcoma;Childhood Soft Tissue Sarcoma;Chimeric Proteins;Chromatin Remodeling Factor;Clinical;clinical development;Clinical Research;Clinical Trials;Combined Modality Therapy;Complex;curative treatments;Cytotoxic Chemotherapy;Data;Dependence;Development;Disease;Disease remission;Dose;Enhancers;Exhibits;experience;Feedback;FOXO1A gene;fusion gene;Future;Gene Fusion;Generations;Genetic;Genetic Transcription;Goals;improved;In complete remission;in vitro testing;Informatics;inhibitor;insight;kinase inhibitor;Knowledge;Label;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Messenger RNA;Mitogen-Activated Protein Kinases;Modeling;Molecular;mRNA Translation;mutant;Oncogenes;Oncogenic;Oncoproteins;Output;Pathway interactions;patient derived xenograft model;Patient observation;Patients;PAX3 gene;PAX7 gene;pharmacodynamic model;pharmacologic;phase 1 study;phase 1 testing;Polyribosomes;pre-clinical;Pre-Clinical Model;Precision therapeutics;preclinical trial;prevent;prognostic;programs;Protein Biosynthesis;Proteins;Proteomics;Ras Inhibitor;Reader;Relapse;Remission Induction;Residual Neoplasm;Resistance;resistance mechanism;response;Retreatment;Rhabdomyosarcoma;ribosome profiling;Role;Signal Transduction;Sirolimus;synergism;targeted treatment;Testing;therapeutic target;Transcript;transcription factor;Translating;Translations;Untranslated Regions

PROJECT_TITLE: Targeting mTORC1 translational control in FOXO1 fusion positive rhabdomyosarcoma


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lupus;Prevention

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project narrative Lupus is an autoimmune disease with a genetic basis. We have identified a transcription factor, Pbx1, with an altered expression in the immune cells of both mice and people with lupus. The goal of this project is to use a multipronged approach to characterize how Pbx1 regulates the function of healthy and lupus immune cells. The long term of the project is a better understanding of the alterations of the immune system caused by a gene that predispose to lupus.

PI_NAMEs: MOREL, LAURENCE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Amino Acid Sequence;Apoptosis;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Binding Sites;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Assay;Chromatin;Chromosome 1;chronic graft versus host disease;comparison control;defined contribution;disease model;DNA;DNA Binding;Dominant-Negative Mutation;Exons;experimental study;Family member;Flow Cytometry;FOXP3 gene;Frequencies;Functional disorder;Funding;Gene Expression Profile;Gene Expression Profiling;Gene Targeting;Genes;Genetic;genetic variant;Genetic Variation;Goals;graft versus host disease induction;Homeostasis;Human;Immune;Immune system;Immunization;Immunosuppression;Impairment;In Vitro;in vivo;Inflammatory;insight;Lesion;Lupus;lupus-like;Lymphocyte;Maintenance;Maps;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;Mus;novel;overexpression;Pathogenesis;Pathway interactions;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Predisposition;Process;Production;Proliferating;Protein Isoforms;Proteins;Proteomics;Regulatory T-Lymphocyte;Repressor Proteins;response;risk variant;RNA Splicing;Role;single-cell RNA sequencing;SLEB1 gene;Structure;Susceptibility Gene;Systemic Lupus Erythematosus;T cell regulation;T cell response;T-Cell Activation;T-Lymphocyte;Time;transcription factor;Transforming Growth Factor beta;transgene expression;Tretinoin;Validation;Work

PROJECT_TITLE: Characterization of SLE-susceptibility loci on mouse chromosome 1

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Juvenile social isolation has dramatic long-term, and until now irreversible, negative effects on behavior and cognitive function. A better understanding of the molecular and cellular processes that underlie the impact of juvenile social isolation on the brain could lead to new therapies to treat those who have been isolated or neglected in childhood.

PI_NAMEs: CORFAS, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Adolescent;Affect;Alleles;Attenuated;Auditory area;Axon;Behavior;Behavioral;behavioral phenotyping;behavioral study;Brain;Brain region;Cell Physiology;Cells;Child;child neglect;Childhood;Cognitive;Cognitive deficits;cognitive function;Collaborations;Corpus Callosum;Data;Defect;density;Development;Down-Regulation;endophenotype;Epigenetic Process;epigenetic regulation;excitatory neuron;executive function;Fostering;Functional disorder;Gene Expression;Gene Modified;Genes;genetic manipulation;histological studies;Histone Deacetylase;imaging study;Impaired cognition;In Vitro;in vivo;inhibitory neuron;insight;Intervention;Knowledge;Lasers;Ligands;Link;Mediating;Memory;Mental disorders;Mental Health;Modeling;Molecular;Motor Cortex;Mus;Myelin;myelination;neglect;neural circuit;Neuregulin 1;neuronal circuitry;Neurons;novel therapeutics;Oligodendroglia;overexpression;Parvalbumins;patch clamp;pharmacologic;Phenocopy;Phenotype;Physiological;Physiology;Play;Prefrontal Cortex;prevent;Process;Property;Protein Isoforms;Publishing;receptor;Receptor Activation;Receptor Signaling;Regulation;restoration;Role;Scanning;Signal Pathway;Signal Transduction;Social Environment;Social Interaction;Social isolation;Structure;Testing;Work

PROJECT_TITLE: Mechanisms of Social Isolation-Induced Alterations in Prefrontal Cortex Myelin, Neural Circuits and Behavior

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Opioids;Pain Research;Precision Medicine;Prescription Drug Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Over-prescription of opioids for surgical pain has contributed at large to the opioid epidemic, so it is important to reduce opioid prescriptions for patients who will receive good pain relief with non-addictive pain relievers, like nonsteroidal anti-inflammatory drugs (NSAIDs). Numerous clinical trials of pain management after wisdom tooth extraction surgery have demonstrated that most patients experience good pain relief with NSAIDs alone, but some patients require opioids in addition to NSAIDs. The goal of this project is to identify the factors that contribute to the need for opioid after wisdom tooth extraction to help limit unnecessary opioid prescriptions in patients who will have good pain relief with NSAIDs alone.

PI_NAMEs: THEKEN, KATHERINE NICOLE (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acute;Algorithms;Analgesics;Automobile Driving;Bioinformatics;biomarker identification;Body mass index;candidate marker;Clinical;clinical practice;Clinical Trials;Data;Demographic Factors;Dental;Dental Care;Development;Dinoprostone;Ensure;experience;Foundations;Future;Gender;Goals;Heterogeneity;Ibuprofen;In Vitro;Individual;Individual Differences;Inflammatory;Inflammatory Response;insight;Integration Host Factors;inter-individual variation;Intervention;Logistic Regressions;Mediating;Modeling;Molecular;multiple omics;neutrophil;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid epidemic;opioid use;Oral Surgeon;Pain;Pain management;pain model;pain relief;Pathway interactions;Patients;patients who use opioids;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Play;Postoperative Pain;precision drugs;precision medicine;predicting response;predictive marker;prescription opioid;prescription opioid misuse;primary outcome;Process;Prospective Studies;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Proteomics;Public Health;Recommendation;Regimen;Regulation;response;Role;Sampling;standard of care;surgical pain;systemic inflammatory response;Testing;third molar extraction;Tooth Extraction;transcriptomics;Trauma;urinary;wisdom tooth;Work

PROJECT_TITLE: Mechanisms of Variability in the Analgesic Response to Ibuprofen Following Third Molar Extraction

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative This proposal describes the continuation of an Undiagnosed Diseases Network (UDN) Clinical Site at Baylor College of Medicine as a regional and national referral site for clinical evaluation of undiagnosed disease with focus on virtual engagement and under-served and under-insured populations.

PI_NAMEs: BACINO, CARLOS A.;LEE, BRENDAN  (contact);ROSENFELD MOKRY, JILL ANNE

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;Adult;analysis pipeline;Bioinformatics;Biological;care costs;Caring;Childhood;Clinic;Clinical;clinical care;clinical diagnosis;clinical research site;Clinical Trials;Collaborations;college;Communities;community engagement;Community Health;community partners;Complement;Consult;cost;County;data sharing;Diagnostic;Diagnostic Procedure;Disease;disease mechanisms study;Educational process of instructing;empowerment;Ensure;Equity;Etiology;Evaluation;exome;exome sequencing;Extramural Activities;Fee-for-Service Plans;Fibroblasts;Funding;gene discovery;Genes;Genetic;Genetic Medicine;genetic resource;genetic variant;genome sequencing;Genomics;Human Genetics;Hybrids;Induced Neurons;Infrastructure;innovation;innovative technologies;Institution;Joint Ventures;Laboratories;Leadership;Link;Medical center;Medical Genetics;Medicine;Modeling;Molecular Analysis;Molecular Genetics;multiple omics;nanopore;National Center for Advancing Translational Sciences;National Human Genome Research Institute;Neurology;Organization administrative structures;pan-genome;Participant;Patients;Pediatrics;peer;Phase;phase 2 testing;point of care;Population;Prenatal care;Process;programs;Protocols documentation;Qualifying;Recording of previous events;recruit;Research;Research Activity;research clinical testing;Research Support;Resource Sharing;Resources;Scholars Program;Services;Site;standard of care;success;telehealth;Texas;Tissues;Transcript;transcriptome sequencing;Travel;Underinsured;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Variant;virtual;virtual platform;Whole Blood;whole genome

PROJECT_TITLE: UDN Diagnostic Center of Excellence at Baylor College of Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Public Health Relevance/Narrative This project proposes AI-Campus workshops to revolutionize healthcare with AI and machine learning to promote diversity and inclusion. It uses a multi-faceted approach that encompasses a series of events, including online competitions and workshops. It helps providing more opportunities for junior and underrepresented researchers to engage with AI in healthcare.

PI_NAMEs: HUANG, XIUZHEN  (contact);JIANG, XIAOQIAN ;WALKER, KARL

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;Artificial Intelligence;care outcomes;career;Collaborations;Communities;COVID-19;Data Set;design;diversity and inclusion;Dreams;Education;Educational workshop;empowerment;Ensure;Environment;Ethics;Event;experience;Face;Faculty;Fostering;Future;Genomics;Goals;Health Care Sector;Healthcare;Healthcare Systems;Hispanic-serving Institution;Historically Black Colleges and Universities;improved;improved outcome;Individual;innovation;insight;Institution;interest;Knowledge;Learning;Legal;Machine Learning;machine learning model;Minority-Serving Institution;Modeling;Nature;news;Outcome;Participant;Patient-Focused Outcomes;Performance;Postdoctoral Fellow;Privacy;programs;public health relevance;Reporting;Research;Research Personnel;Resources;Series;skills;Students;success;Talents;Technology;tool;Underrepresented Populations;Vision;World Health

PROJECT_TITLE: AI-Campus Workshops: Revolutionizing Healthcare with AI and Machine Learning to Promote Diversity and Inclusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Immunotherapy;Maternal Health;Maternal Morbidity and Mortality;Organ Transplantation;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Transplantation;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Pregnancy complications are common in organ transplant recipients, but little is understood about the mechanisms of pathogenesis. Uterine natural killer cells have important roles in pregnancy well-being and are altered by immunosuppression medications taken by transplant recipients. We use a unique model of human uterus transplantation to better understand how immunosuppression agents impact the normal function of uterine natural killer cells and lead to complex pregnancy.

PI_NAMEs: PORRETT, PAIGE M (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Abnormal placentation;Affect;Age;Antigen Receptors;B-Lymphocytes;Biological;Biological Models;Biology;Biopsy;Blood flow;Calcineurin inhibitor;Calcium Signaling;Cardiovascular system;Cell Count;cell type;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;cohort;Complement;Complex;Defect;Development;Disease;Eclampsia;effective therapy;Electric Capacitance;Endometrial;Endometrium;experimental study;Female;Fetal Growth Retardation;Fetal health;Fetal Mortality Statistics;Flow Cytometry;Functional disorder;General Population;Goals;Health;Healthcare;high dimensionality;Histology;Homeostasis;Host Defense;Human;human model;imaging modality;imaging study;Immune;Immunofluorescence Microscopy;Immunosuppression;Impairment;improved;In Vitro;in vivo;insight;Interleukin-15;interleukin-15 receptor;Kidney;Knowledge;Maternal Health;Maternal Mortality;Mediating;men;Minority;Molecular;Morbidity - disease rate;Mus;Natural Killer Cells;Normal tissue morphology;nuclear factors of activated T-cells;Nuclear RNA;Organ;organ transplant recipient;Organ Transplantation;Pathogenesis;Pathology;patient population;Patients;Perfusion;Personal Satisfaction;Pharmaceutical Preparations;Phase;Phenotype;Placenta;Placentation;Play;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pressure;prevent;Receptor Signaling;reproductive;Reproductive Biology;Reproductive Immunology;Residencies;response;Risk;Role;Sampling;Signal Transduction;single cell technology;single-cell RNA sequencing;Spiral Artery of the Endometrium;T-Lymphocyte;Testing;Tissues;transcriptome sequencing;transcriptomics;Translating;Translations;Transplant Recipients;Transplantation;transplantation medicine;Uterus;Vascular Endothelial Growth Factors;virtual;Woman;Women's Health

PROJECT_TITLE: Tissue-resident NK cell development and function in pregnancy and transplantation: lessons learned from human uterus transplant recipients

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Drug Abuse (NIDA only);Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Statement Preventing or delaying adolescent substance use (SU) is a critical goal because the risk of developing lifelong substance use problems is elevated in individuals who began using as adolescents. The proposed R21 will develop a new analytic model that will improve our ability to make causal inferences between potential intervention targets and SU, and freely provide the code and information on power to maximize its utility for scientists who use large-scale longitudinal data. Our results using this model will also advance understanding of the transactional development of different aspects (i.e., parent- and child-driven) of parental monitoring and adolescent SU, which will be of immediate use to individuals designing and testing adolescent SU prevention and interventions by zeroing in on the specific behaviors most likely to be causally linked to SU and the level at which (individual, family) they influence SU outcomes.

PI_NAMEs: MARCEAU, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent alcohol and drug use;adolescent substance use;Alcohol consumption;Behavior;Brain;causal model;Child;Child Health;Code;cognitive development;Data;data harmonization;Data Set;design;Development;Disclosure;Effectiveness;Environment;Environmental Risk Factor;Etiology;experience;Familiarity;Family;Future;Genetic;Goals;Grant;Health;improved;Individual;Intercept;interest;Intervention;Intervention Trial;Knowledge;Link;Literature;Longitudinal, observational study;marijuana use;Measures;member;model development;model generalizability;Modeling;Monitor;National Institute of Drug Abuse;National Longitudinal Survey of Adolescent to Adult Health;novel;Outcome;parental monitoring;Parents;Persons;prevent;Prevention;Process;Publications;reduced substance use;Reporting;Research;Research Personnel;Residual state;Resources;Risk;Sample Size;Sampling;Scientist;Series;Severities;sibling influence;Siblings;simulation;Specific qualifier value;Specificity;Statistical Methods;Structure;substance misuse;substance use;substance use prevention;success;Testing;therapy design;Time;Tobacco use;trait;Transact;Translations;Twin Multiple Birth;United States National Institutes of Health;uptake;willingness;Work

PROJECT_TITLE: Improving Causal Inference for National Adolescent Substance Use Datasets

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: CLEVELAND

ORG_DEPT: UROLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Over 3.5 million US residents have active epilepsy, including >600,000 with temporal lobe epilepsy (TLE), and up to 80% of patients with drug-resistant TLE have impaired memory abilities that have no predictive biomarkers or effective therapies. Our proposed studies aim to understand alterations of gene and protein expression in the temporal lobe that may contribute to memory dysfunction in TLE and to identify biomarkers to stratify patients at high risk for memory impairment. These are crucial first steps in the effort to identify mechanisms of memory impairment in adults with TLE with the future goal of developing evidence-based clinical trials to treat or prevent memory impairment in TLE to improve patient functioning and quality of life.

PI_NAMEs: BUSCH, ROBYN M (contact);NI, YING

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adult;Biological;Biological Markers;biomarker identification;Blood;Brain;Brain region;candidate identification;candidate marker;cell type;Cells;Clinic;Clinical;clinical phenotype;Clinical Trials;cohort;daily functioning;Data;data integration;Data Set;dentate gyrus;Development;differential expression;digital;Drug resistance;effective therapy;Epilepsy;Episodic memory;episodic memory impairment;Etiology;evidence base;Formalin;Freezing;functional improvement;Future;Gene Expression Alteration;Gene Expression Profile;Genes;Genetic Transcription;Glutamates;Goals;High Prevalence;high risk;hippocampal cell loss;hippocampal sclerosis;Hippocampus;improved;innovation;Language;Lateral;Measurable;medial temporal lobe;Memory;Memory impairment;memory process;Mendelian randomization;MicroRNAs;Modeling;Molecular;molecular marker;Molecular Profiling;Neocortex;neocortical;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurobiology;Neurodegenerative Disorders;Neurons;novel;Operative Surgical Procedures;overexpression;Paraffin Embedding;Pathogenesis;Pathologic;patient stratification;patient subsets;Patients;Pattern;Performance;Peripheral;peripheral blood;Phenotype;Plasma;Play;predictive marker;prevent;Process;prognostication;prospective;Prospective cohort;protein expression;Proteins;Proteome;Publishing;Quality of life;regional difference;Research;Resected;Resolution;Resources;Role;Series;Severity of illness;Signal Pathway;single nucleus RNA-sequencing;Tauopathies;Temporal Lobe;Temporal Lobe Epilepsy;Tissue Embedding;Tissue-Specific Gene Expression;Tissues;Transcript;transcriptome

PROJECT_TITLE: Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The innate immunity is our first-responder system that senses and responds rapidly to virus infection to protect us on a daily basis against infection. Many aspects of how this sensing is propagated, how it protects us from infection, and how it can lead to potentially pathogenic sequelae remain poorly understood. This work will define these processes by studying the neurotropic pathogen West Nile virus.

PI_NAMEs: GALE, MICHAEL ;OBERST, ANDREW ATWELL (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: acute infection;adaptive immune response;adaptive immunity;Address;Anti-viral Response;Binding;Biochemical;Bite;blood-brain barrier crossing;Body System;Cause of Death;Cell Survival;cell type;Cells;Central Nervous System;climate change;Cognitive;conditional knockout;Culicidae;Data;Dendritic Cells;Developed Countries;Differentiation Antigens;Disease;experience;Family;first responder;Flavivirus;Flavivirus Infections;Functional disorder;functional genomics;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Health;Host Defense;Human;Immune;immune activation;Immunity;Immunocompetent;Immunologics;Impaired cognition;Impotence;Infection;Infection Control;Inflammation;Inflammatory;Innate Immune Response;insight;Interferon Type I;Interferons;Invaded;Knockout Mice;Knowledge;Lead;Ligands;long-term sequelae;Macrophage;Mediating;member;Modeling;Molecular;mouse model;Multiple Myeloma;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Nature;Neurologic;neuronal survival;Neurons;neurotropic;novel;Outcome;pathogen;pathogenic virus;Pathogenicity;Pathology;Patients;Pattern;Peripheral;Phase;Play;prevent;Process;programs;receptor;Receptor Activation;Receptor Signaling;Reporter;response;RNA;Role;Signal Transduction;Source;Survivors;System;Tissues;tool;transcriptomics;transmission process;Tretinoin;Tropism;Viral;viral genomics;viral RNA;Virus;Virus Diseases;Virus Replication;West Nile viral infection;West Nile virus;Work

PROJECT_TITLE: Innate Immunity to West Nile Virus

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Suicide

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE A first episode of psychosis is a leading cause of disability in young adults, with high risk of suicide and all cause mortality. A substantial part of the burden and cost relates to poor functional outcomes, and the inability to determine the right antipsychotic treatment during the earliest phases of psychotic illness, particularly for those who might need clozapine, a medication that is already known to work best for those who do not respond to conventional antipsychotics. In patients with a first episode of psychosis, the present study aims to determine whether the use of biomarker guided treatment decisions leads to better outcomes and equivalent side effects in people prescribed clozapine compared to conventional antipsychotics, including changes in brain function.

PI_NAMEs: CADENHEAD, KRISTIN S. (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acceleration;acute care;Adherence;Adolescence;Age;aged;Agranulocytosis;Antipsychotic Agents;aripiprazole;Biological Markers;blind;Brain;Brain scan;Caring;Clinical;Clozapine;cohort;Complex;Controlled Study;Corpus striatum structure;cost;Country;critical developmental period;critical period;Data;Decision Making;Dedications;Development;disability;dissemination strategy;Dose;early psychosis;Education;efficacy evaluation;efficacy trial;Elements;emerging adult;Employment;expectation;experience;Failure;Family;Family member;Feeling suicidal;first episode psychosis;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Future;General Population;genetic testing;genomic locus;Genotype;Goals;high risk;HLA-DQB1;Hospitalization;Hospitals;Image;implementation science;improved;improved outcome;indexing;Individual;inpatient service;Lifelong disability;Lived experience;Magnetic Resonance Imaging;Melanocortin 4 Receptor;mortality;National Institute of Mental Health;Neutropenia;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacogenetics;Phase;Population;Precision therapeutics;predicting response;predictive marker;preservation;primary outcome;Psychiatry;Psychoses;psychotic;Psychotic Disorders;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Receptor Gene;reducing suicide;Research Design;Resistance;responders and non-responders;response;Rest;Risk;risk variant;Risperidone;Schizophrenia;secondary outcome;Services;side effect;specific biomarkers;Subgroup;suicidal morbidity;suicidal risk;support tools;Symptoms;System;Testing;Therapeutic;tool;treatment response;trial comparing;Weight;Weight Gain;Work;young adult;Youth

PROJECT_TITLE: 5/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-S (60)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Perceptual awareness is essential to normal human function and is impaired in many cognitive disorders. Complementary imaging, electrical and behavioral approaches will allow us to pinpoint the shared common deep brain regions involved in perception, regardless of whether the stimulus is seen, heard, or felt by touch. Understanding the mechanisms of perception independent of which sensory modality is involved may lead to better, targeted therapies aimed at improving a broad range of disorders.

PI_NAMEs: BLUMENFELD, HAL  (contact);QURAISHI, IMRAN H

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Area;Arousal;Auditory;Awareness;basal forebrain;Behavioral;Blinking;Brain;Brain region;Brain Stem;Chronic;Cognition;Cognition Disorders;Data;Data Reporting;Data Set;Disease;Epilepsy;experimental study;Eye Movements;Functional Magnetic Resonance Imaging;hands-on learning;Hearing;Human;Image;Impairment;implantable device;Implanted Electrodes;improved;Machine Learning;Measurement;Measures;Methods;Midbrain structure;Modality;neural;Patients;Perception;Perceptual Disorders;Phase;Physiologic pulse;Play;Probability;Pupil;Regional Anatomy;Reporting;Resolution;Role;Saccades;Sensory;sensory stimulus;Signal Transduction;Sleep;Stimulus;System;Tactile;targeted treatment;Techniques;Thalamic structure;therapeutic target;Time;Touch sensation;Training;vigilance;Visual;Visual Perception;visual stimulus;Work

PROJECT_TITLE: Shared Subcortical Arousal Systems Across Perceptual Modalities

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Normal responses to environmental stimuli are disrupted in many neuropsychiatric disorders, leading to damaging behavioral outcomes. This study will determine the role of the amygdalostriatal transition zone (ASt) - an almost completely unstudied structure - in mediating learned behavioral responses to stimuli that predict rewards or punishments. The proposed research project will increase our knowledge of the fundamental neural mechanisms underlying associative learning and motivated behaviors, and could identify ASt circuits as novel targets of interest for psychological disorders such as anxiety, depression, and post-traumatic stress disorder.

PI_NAMEs: MILLS, FERGIL  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;Animals;Anxiety;Association Learning;Aversive Stimulus;Basic Science;Behavior;Behavioral;behavioral outcome;behavioral response;Bilateral;Biological;Brain;career development;Cell Nucleus;Cells;Complex;Computer Analysis;conditioned fear;Conditioned Reflex;Consensus;Corpus striatum structure;Cues;Data;Data Analyses;deep neural network;discrimination task;Disease;Electrophysiology (science);Event;experience;experimental study;fitness;Genetic Complementation Test;Health;Human;in vivo;innovation;insight;interest;Knowledge;Lateral;learned behavior;Learning;loss of function;Mediating;Mental Depression;Mental disorders;Mentors;Methods;Modeling;motivated behavior;Motor output;Nervous System Disorder;neural circuit;neuromechanism;Neurons;neuropsychiatric disorder;novel;optogenetics;Outcome;Output;Pathologic;Pathway interactions;Phase;Play;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Predictive Value;Process;programs;Punishment;Research;Research Personnel;Research Project Grants;Residual state;response;Rewards;Role;Sensory;Site;Slice;Source;Stimulus;Stream;Structure;Synapses;Thalamic structure;Training

PROJECT_TITLE: Determining the role of amygdalostriatal transition zone circuits in associative learning and motivated behaviors

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Mexico-US immigration is increasingly common and Mexican Americans are one of the fastest growing and aging populations in the United States, yet methodological challenges rooted in migrant selection and the Latino paradox hamper understanding of the effects of their migration experience on ADRD risk. A pooled binational life course dataset with harmonized cognitive outcomes and built-in longitudinal propensity scores of healthy in- migration and unhealthy out-migration provides a unique opportunity to rigorously examine these relationships. In this study, we leverage our previously created pooled binational life course dataset to estimate the association of migration and ADRD risk using the newly improved HCAP data, assess how the socio-political context influences this relationship, and examine underlying biosocial pathways.

PI_NAMEs: GLYMOUR, MEDELLENA MARIA;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acculturation;Address;Adult;Age;age acceleration;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Biological;Biology;Biosocial;Birth;Characteristics;Climate;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Communities;Complex;Country;Data;Data Set;Data Sources;Dementia;dementia risk;Disadvantaged;Education;Enrollment;ethnic health disparity;Etiology;experience;Exposure to;Friends;Health;Health and Retirement Study;Health Status;Immigrant;Immigration;improved;Individual;Inflammation;innovation;insight;International Migrations;Investigation;Knowledge;Latino;Life;Life Cycle Stages;Masks;Measures;Mediating;Methodology;Mexican;Mexican Americans;Mexico;Migrant;migration;minority stressor;Modeling;Modernization;Nonmigrant;novel;Older Population;Out-Migrations;Outcome;Pathway interactions;Policies;Politics;Population;Predictive Factor;Protocols documentation;Publishing;racial disparity;remediation;Research;residence;Risk;Risk Factors;Sampling;Shapes;Sister;Skin;Social Environment;social epidemiology;socioeconomic disadvantage;Socioeconomic Status;stressor;systemic inflammatory response;Time;United States;Update;Weight;Work

PROJECT_TITLE: A Multilevel Investigation of Migration and Dementia Risk Among Mexican Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Early detection of Alzheimer's Disease and Related Dementias is vital, with gait speed as a potent predictor, particularly in its early stage of Mild Cognitive Impairment (MCI). The proposed work investigates cognitive contributions of gait control, focusing on locomotor learning and attentional need for walking, in MCI vs. healthy aging and its relation to basal ganglia networks. This is done aiming to unveil neural mechanisms underlying the relation between mobility and cognitive decline and enhance early ADRD risk prediction.

PI_NAMEs: TORRES-OVIEDO, GELSY  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;attentional control;Basal Ganglia;Behavioral;Biomedical Engineering;Caregivers;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive task;Communities;Compensation;Data;Deposition;Early Diagnosis;Early identification;Elderly;Epidemiologist;executive function;Exhibits;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Gait;Gait abnormality;Gait speed;Goals;Health;healthy aging;high risk;Ice;Impaired cognition;Impairment;improved;Individual;insight;Intervention;Iron;Learning;Leg;Measures;Memory;mild cognitive impairment;Mobility decline;Motor;motor learning;neural;Neurobehavioral Manifestations;neuroimaging;neuromechanism;novel;older adult;Participant;Pathology;Pattern;Performance;Play;pre-clinical;Prefrontal Cortex;Process;Protocols documentation;Proxy;Qualifying;Regression Analysis;Research;Research Project Grants;Resources;Rest;Risk Marker;risk prediction;Role;sex;Societies;Specificity;Speed;Statistical Models;Surface;Task Performances;Testing;Time;Walking;White Matter Hyperintensity;Work;young adult

PROJECT_TITLE: Neural Mechanisms Underlying Cognitive Contributions to Walking as an Early Marker for Risk of Alzheimer’s Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Poor sleep health (e.g., insufficient sleep duration, fragmented sleep, untreated sleep disorders) is highly prevalent among older adults and associated with increased risk of Alzheimer’s Disease (AD). We propose to conduct User Centered Design research that will culturally adapt our existing Sleep Health and Wellness (SHAW) program to the needs of cognitively unimpaired older adults residing in low-income housing in Boston aimed at improving sleep, quality of life, and cognitive function. The SHAW program will be comprised of sleep, mindfulness, and sleep disorders modules, and we propose to disseminate the adapted SHAW modules in a novel social network intervention that identifies, trains, and motivates socially well-connected older adults in each facility to diffuse the SHAW materials through interpersonal communication and small group sessions.

PI_NAMEs: ROBBINS, REBECCA  (contact)

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TERMS: acceptability and feasibility;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Award;Back;behavior change;behavioral health;Boston;catalyst;Cerebrospinal Fluid;Characteristics;Cities;Cognition;Cognitive;cognitive function;cohesion;Collaborations;Communication;Critiques;Data;design;Diffuse;Diffusion;Education;Educational process of instructing;Ensure;Evaluation;experience;Exposure to;Feasibility Studies;Feedback;Goals;Health behavior;Housing;Impaired cognition;improvement on sleep;Individual;Instruction;instructor;Interview;Leadership;Length;Low income;member;mindfulness;mindfulness intervention;multidisciplinary;novel;older adult;Pathogenesis;Personal Communication;Pilot Projects;pilot test;Polysomnography;poor sleep;programs;Protocols documentation;prototype;Qualifying;Quality of life;Randomized, Controlled Trials;recruit;Research;Research Design;Research Personnel;residence;Resource-limited setting;Resources;Sleep;Sleep Deprivation;sleep difficulty;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep health;social;Social Network;social network intervention;Source;stress reduction;Surveys;System;tau Proteins;Testing;Thinking;Time;Trainers Training;Training;Trust;usability;user centered design;wearable device;Wellness Program

PROJECT_TITLE: Leveraging social networks to improve sleep and mindfulness among older adults in low-income housing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A1)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Lipoproteins are dynamic complexes of lipid and protein in the circulation that are correlated with cardiovascular events. This project will examine a novel functional interaction between the antiinflammatory plasma protein alpha-1-antitrypsin and lipoproteins. These studies will test the hypothesis that lipoproteins influence the function of alpha-1-antitrypsin and this contributes to protection against atherosclerotic cardiovascular disease by reducing vascular inflammation.

PI_NAMEs: GORDON, SCOTT M (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Affinity;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Anti-Inflammatory Agents;Apolipoproteins;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;atherosclerosis risk;Binding;Binding Proteins;biobank;Biological Assay;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Circulation;Complex;Coronary Arteriosclerosis;crosslink;Data;density;Dyslipidemias;elastase inhibitor;Elastases;Elasticity;endothelial dysfunction;Endothelium;Enzymes;Event;Genes;Genetic Variation;Hepatic;High Density Lipoproteins;high risk;Human;In Vitro;in vivo;Inflammation;Inflammatory;Infusion procedures;Investigation;Knowledge;Lesion;Lipid Binding;lipid metabolism;lipid transport;Lipids;Lipoprotein (a);Lipoprotein Binding;Lipoproteins;Literature;Low-Density Lipoproteins;Macrophage;Maps;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Modeling;Morphology;mouse model;Mus;neutrophil;neutrophil elastase inhibitor;novel;Ontology;Paint;particle;Pathway interactions;Peptide Hydrolases;peptidomimetics;Phenotype;Physiological;Plasma;Plasma Proteins;Play;preservation;prevent;Prevention;Protease Inhibitor;Protein Array;Protein C Inhibitor;Proteins;Proteomics;restoration;Risk;Role;Rupture;Serine Protease;Signal Transduction;small molecule;Structure;synthetic peptide;Testing;tool;transcytosis;vascular inflammation;western diet;Work

PROJECT_TITLE: Functional Interactions Between Lipoproteins and Protease Inhibitors in Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Immunization;Immunotherapy;Lung;Lung Cancer;Microbiome;Prevention;Radiation Oncology;Vaccine Related;Women's Health Research

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Approximately 40% of the more than 500,000 women diagnosed globally with locally advanced cervical cancer (LACC) will relapse and die of disease despite receiving curative treatment. We identified a critical bacteria, Lactobacillus iners (L. iners), in the cervical tumor microbiome, which rewires tumor metabolism to utilize lactate and is associated with treatment resistance and poor survival across several cancer types. Our objective is to understand how L. iners influences cervical cancer cells and immune cells (Aim 1) and design novel therapeutics by targeting either tumor resident bacteria (Aim 2) or metabolic effects of tumor resident bacteria (Aim 3) in the tumor and tumor microenvironment.

PI_NAMEs: COLBERT, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Affect;Antibiotic susceptibility;Bacteria;Biological;Biological Assay;Bioreactors;cancer cell;Cancer Cell Growth;cancer diagnosis;cancer genome;cancer therapy;cancer type;Carbohydrates;Cell Physiology;Cells;Cellular Metabolic Process;cervical cancer prevention;Cervical dysplasia;cervicovaginal microbiome;Cervix Neoplasms;chemoradiation;Cisplatin;Clinical;Clinical Trials;Coculture Techniques;Colorectal Adenocarcinoma;Communities;Complex;COVID-19 pandemic;curative treatments;Cytometry;Death Rate;Dendritic Cells;design;Disease;Drops;efficacy testing;enantiomer;Engineered Gene;Engineering;Future;Galactose;Genes;girls;Glycolysis;Head and Neck Cancer;HPV vaccine acceptance;Human Papilloma Virus Vaccine;Human Papillomavirus;Immune;immune checkpoint blockade;Immune System Diseases;Immunohistochemistry;Immunologic Stimulation;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Incidence;Inflammatory;inhibitor;Investigational New Drug Application;Knock-out;Laboratories;Lactate Dehydrogenase;lactic acid bacteria;Lactobacillus;Lactose;Lead;live cell imaging;Macrophage;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;medically underserved;Melanoma;Metabolic;Metabolic Pathway;Metabolism;microbial community;microbiome;microbiome therapeutics;Minority Women;Mitochondria;Modeling;monocyte;mouse model;Mus;Neck Cancer;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Organoids;pandemic disease;Patients;Peptides;Pharmaceutical Preparations;Population;Prevention approach;Primary Prevention;Prognostic Factor;Protein Isoforms;Proteins;Proteomics;Radiation Induced DNA Damage;reconstitution;Recurrence;Relapse;Resistance;Safety;Sampling;screening;Secondary Prevention;Signaling Molecule;Site;standard of care;Survival Rate;synergism;T cell anergy;Testing;Therapeutic;therapy resistant;treatment response;tumor;tumor metabolism;tumor microbiome;tumor microenvironment;United States;Vaccinated;Vaccination;Vaccines;Woman;women's diagnosis;World Health Organization

PROJECT_TITLE: Targeting tumoral Lactobacillus iners to improve outcomes in cervical cancers

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention

PHR: NARRATIVE The past two decades have witnessed several air-borne viruses (SARS-CoV1, MERS, SARS-CoV2) that led to significant mortality. Here, we propose to engineer a novel intranasal-delivered nanoparticle that exerts a universal antiviral effect by activating a unique evolution-encoded innate immune state in nasal epithelial cells. This study can shift the paradigm for early interventions in emerging viruses/future pandemics and generate fundamental insights into innate immune sensing of viral nucleic acids.

PI_NAMEs: MAHAJAN, VINAY SUBHASH (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: 2019-nCoV;Address;Advanced Malignant Neoplasm;Affinity;Air;anti-viral efficacy;Anti-viral Response;Anti-viral Therapy;Artificial nanoparticles;Binding;Biodistribution;Brain;Cells;Charge;Clinical Trials;COVID-19 patient;design;Distant;Drug Kinetics;Early Intervention;emerging virus;Engineering;Environment;Epithelial Cells;Evolution;future pandemic;Heart;Immune;immune activation;Immune response;Immunotherapy;In Vitro;in vivo;Individual;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus strain;inhibitor;innate immune sensing;insight;Interferon Type I;Interferons;Laboratories;Lead;Liquid substance;Lung;Lymphocyte Subset;Measures;Messenger RNA;methyl group;Methylation;Methyltransferase;Middle East Respiratory Syndrome;Modeling;Molecular;mortality;mouse model;Mucous body substance;Mucous Membrane;Mus;Myelogenous;Nanodelivery;nanoengineering;nanoparticle;nanoparticle delivery;Nasal cavity;Nasal Epithelium;Nasopharynx;Nature;Nose;novel;Nucleic Acids;Nucleosides;overexpression;pandemic influenza;Paper;pathogen;Patients;Paxlovid;Peptides;Pharmaceutical Preparations;Plaque Assay;prevent;Primary Infection;Property;prophylactic;Prophylactic treatment;Proteins;Protocols documentation;prototype;Publishing;Reporting;response;Ribose;RNA Viruses;Role;Route;Safety;SARS coronavirus;SARS-CoV-2 inhibitor;sensor;Signal Pathway;Site;Spleen;Structure of germinal center of lymph node;Surface Properties;Testing;Time;Translations;transmission process;Vaccines;validation studies;Viral;Viral Load result;Virus;Virus Replication

PROJECT_TITLE: A universal intranasal nanoengineered therapy against airborne RNA viruses

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infant Mortality;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Streptococcus agalactiae is a Gram positive bacterium that can cause invasive infections during pregnancy which lead to severe disease outcomes including premature rupture of gestational membranes, preterm birth, neonatal sepsis and death. This translational research project seeks to determine if application of human breast milk sugars can prevent S. agalactiae pathogenesis, the host immune response and disease progression. The results from the proposed experiments could lead to new approaches for the prevention of GBS-associated diseases and cost-effective treatment strategies to mitigate the risk of infections during pregnancy.

PI_NAMEs: GADDY, JENNIFER A (contact);TOWNSEND, STEVEN D.

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Adherence;adverse pregnancy outcome;Affect;amniotic cavity;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Cells;Cervix Uteri;Chemosensitization;Coculture Techniques;cost effective;cost effective treatment;cytokine;Data;defined contribution;dietary;Disease;Disease Outcome;Disease Progression;Encapsulated;epidemiologic data;Epithelium;Exhibits;experimental study;Exposure to;extracellular;fetal;Fetal Diseases;Fetus;Gram-Positive Bacteria;Gravid;Group B Streptococcus colonization;Human;Human Milk;human milk oligosaccharides;Immune;Immune response;Immune System Diseases;Immunologics;immunoregulation;improved;in vivo;Infection;infection risk;Inflammation;Inflammatory;Intervention;intraamniotic infection;intrauterine infection;Invaded;Macrophage;Maternal-Fetal Exchange;Membrane;membrane model;Microbial Biofilms;microbiome;Modeling;mouse model;Neonatal Mortality;neonatal outcome;neonatal sepsis;neonate;novel strategies;novel therapeutic intervention;Oligosaccharides;organ on a chip;Outcome;pathogen;Pathogenesis;Perinatal;Permeability;Persons;Phagocytosis;Placenta;placental membrane;prebiotics;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;Premature Labor;Premature Rupture Fetal Membranes;preterm premature rupture of membranes;prevent;Prevention approach;Process;Production;Publishing;Reactive Oxygen Species;recruit;Repression;reproductive;reproductive tract;Research Personnel;Research Project Grants;response;Risk;risk mitigation;Rupture;screening;Signal Transduction;stillbirth;Streptococcal Infections;Streptococcus Group B;sugar;Surface;System;Testing;Therapeutic;Tissue Model;Tissues;Translational Research;treatment strategy;Uterus;vaccine access;Vagina;vaginal infection;vaginal microbiome;vaginal mucosa;Vulnerable Populations;Work

PROJECT_TITLE: Utility of human milk oligosaccharides against the perinatal pathogen, Group B Streptococcus

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The proposed research focuses on endotypes of Sjögren's disease (SjD), a common systemic autoimmune disease characterized by oral and ocular dryness and marked morbidity, with no available disease modifying treatments. Defining the maladaptive response of endogenous salivary gland mesenchymal stromal cells (MSCs) by endotype will impact human health by providing foundational insights into SjD pathogenesis and serve as the first step toward two new potential and innovative therapies in SjD, 1) salivary gland MSC-targeted therapy, and 2) JAK inhibition for SjD treatment. Thus, the proposed research is relevant to the NIH's mission pertaining to reducing illness and disability.

PI_NAMEs: MCCOY, SARA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Affect;Autoantibodies;Automobile Driving;B-Lymphocytes;biobank;Bioinformatics;Biological Assay;biological heterogeneity;Biology;Biopsy;cell behavior;Cells;chemokine;chemokine receptor;Chemotaxis;Clinical;clinical heterogeneity;Clinical Trials;comparison control;Conditioned Reflex;CXCL9 gene;CXCR3 gene;cytokine;Cytokine Signaling;Data;disability;Disease;disease heterogeneity;Dryness;Environment;Fatigue;FDA approved;Fluorescent in Situ Hybridization;Future;Genetic Transcription;Goals;Health;Heterogeneity;Human;Immune;Immunobiology;Immunofluorescence Immunologic;immunoregulation;improved;In Situ;In Vitro;in vitro Model;in vitro testing;in vivo;Inflammatory;innovation;Innovative Therapy;insight;JAK1 gene;Janus kinase;kinase inhibitor;Knowledge;Lymphocyte;Lymphocyte Count;Lymphocytic Infiltrate;Maps;Measures;Mediating;mesenchymal stromal cell;Mission;Morbidity - disease rate;mouse model;Mus;neutralizing antibody;novel;Onset of illness;Oral;Oral Characters;Organ;Pain;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Population;Positioning Attribute;pre-clinical;prevent;Proteins;Proteomics;Publishing;Reaction;Research;Resolution;response;Role;Saliva;Salivary Gland Diseases;Salivary Glands;Severity of illness;Signal Pathway;Sjogren's Syndrome;Symptoms;systemic autoimmune disease;T-Lymphocyte;targeted treatment;Technology;Testing;Transcript;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Defining Sjögren’s pathogenesis by endotype: maladaptive responses of endogenous salivary gland mesenchymal stromal cells


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Responses to looming danger, ranging from threat assessment to active avoidance, are critical for survival and well-being. This project leverages pattern recognition techniques to develop models of cortical and subcortical brain pathways involving the superior colliculus to understand their roles in defensive behavior and emotional experience, and how they mature during adolescence. The knowledge generated by this research can inform mechanistic models of emotion processing and may ultimately lead to the development of improved targets for therapeutic interventions.

PI_NAMEs: KRAGEL, PHILIP AUGUSTUS (contact)

PROJECT_TERMS: Adolescence;Adolescent;Affect;Amygdaloid structure;Animal Model;Anxiety;Anxiety Disorders;anxiety symptoms;Arousal;Attention;Attenuated;Aversive Stimulus;Avoidance Learning;Back;Behavior;Behavioral;blood oxygenation level dependent response;Brain;brain pathway;Cell Nucleus;Clinical;clinical development;cognitive development;Color;Communities;Cues;Data;Development;Emotional;emotional experience;emotional stimulus;Emotions;experience;Fright;frontal eye fields;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Health;Human;imaging study;improved;Individual;Individual Differences;insight;Intervention;Knowledge;Lateral;Machine Learning;Measures;Mediating;Memory;Mental Health;midbrain central gray substance;Modeling;multisensory;neuroimaging;new therapeutic target;novel;Parietal Lobe;Participant;Pathway interactions;Patient Self-Report;Pattern;Pattern Recognition;Personal Satisfaction;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Probability;Pulvinar structure;Reaction Time;receptive field;Research;response;Role;Sampling;sensory integration;Short-Term Memory;Signal Transduction;Social Behavior;Specificity;superior colliculus Corpora quadrigemina;System;targeted treatment;Techniques;Testing;Texture;Thalamic structure;Therapeutic Intervention;Time;Trauma;Ventral Tegmental Area;ventral visual stream;Visual;Visuospatial

PROJECT_TITLE: Superior Colliculus Pathways for Defensive Behavior and Emotional Arousal


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Infectious Diseases;Liver Disease;Nutrition

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative Sex impacts the outcome of severe infections. However, current treatment strategies do not provide sex-specific care. The studies outlined in this proposal aim to unravel novel sex-specific targets that impact the outcome of severe infections.

PI_NAMEs: NIKKANEN, JONI  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Accounting;Affect;alternative treatment;Award;Basal metabolic rate;BCL6 gene;Binding Sites;Biological Assay;candidate identification;career;Caring;ChIP-seq;Communicable Diseases;CRISPR/Cas technology;Data;Data Set;Death Rate;Escherichia coli Infections;Exhibits;Fatty acid glycerol esters;Fatty Liver;feeding;Female;fitness;gallin;Genes;genetic manipulation;Genetic Transcription;Genomics;Goals;Gonadal Steroid Hormones;Hepatic;High Fat Diet;Holly;Host Defense Mechanism;Housing;Human;human model;Hyperlipidemia;improved;Infection;Inflammation;insight;Institution;knock-down;Laboratory Research;Life;Lipase;lipid metabolism;Lipids;Lipoproteins;Liver;liver function;liver metabolism;male;Masks;Mediating;men;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;novel;novel strategies;Obesity;Outcome;overexpression;Overnutrition;particle;pathogen;Pathogenicity;Pathway interactions;pharmacologic;Phase;Phenotype;Plasma;post-doctoral training;Postdoctoral Fellow;Predisposing Factor;Predisposition;programs;promoter;Regulation;Research;Research Personnel;response;Risk Factors;Role;Sampling;Scintillation Counting;Sepsis;sex;Sex Bias;Sex Differences;sexual dimorphism;skills;steroid metabolism;Survival Rate;System;Temperature;Testing;thermal stress;Tracer;Training;transcription factor;transcriptome sequencing;treatment strategy;Triglycerides;United States;United States National Institutes of Health;Very low density lipoprotein;Viral

PROJECT_TITLE: Dissecting Sex-Specific Metabolic Responses to Inflammation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]