ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: The Zebrafish International Resource Center 1) provides a central repository for zebrafish wild-type, transgenic, and mutated genetic stocks, and other research materials, 2) provides consultation and pathology services, and 3) researches and develops husbandry standards such as the composition of diets, nutrition requirements, and food management strategies that support ZIRC and research community husbandry goals. ZIRC materials, services, and husbandry and health standards will be made widely available to the research community.

PI_NAMEs: VARGA, ZOLTAN MARTON (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TITLE: Zebrafish International Resource Center (ZIRC)


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Address;Agreement;Alleles;Animals;Biomedical Research;Communication;Communities;Computer software;Consultations;Consumption;Controlled Vocabulary;Data;data acquisition;Data Collection;data curation;data sharing;data standards;data submission;Database Management Systems;Databases;Development;Diagnostic;Documentation;Electronic Mail;Ensure;Equipment and supply inventories;Face;Fishes;Genbank;Gene Expression;Genetic;Genomics;Genotype;Goals;Guidelines;Health;health assessment;Health Services;Health Status;Image;Informatics;Information Networks;International;interoperability;Laboratory Procedures;Licensing;Metadata;Morphology;mutant;Nomenclature;novel;online community;Online Systems;Ontology;Outcome;Output;Performance;Phenotype;Preparation;Procedures;Process;Programming Languages;Protocols documentation;public database;PubMed;Records;Reporting;repository;Reproducibility;Research;Research Personnel;Research Support;Resources;Services;Shipping;Site;Staging;Standardization;symposium;Time;tool;Training;Transgenic Organisms;United States National Institutes of Health;user-friendly;Validation;Visual;Vocabulary;web portal;web site;Work;Zebrafish

PROJECT_TITLE: Zebrafish International Resource Center, Curation and Informatics Admin-Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Epilepsy;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: KINGSVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

ORG_STATE: TX

PHR: Project Narrative The health burdens of pediatric epilepsies are some of the most intractable. A better understanding of Developmental and Epileptic Encephalopathy (DEE)—a severe pediatric epileptic illness is expected to improve therapies and remediation. At its most optimistic, a better understanding might lead to a better targeted anti-epileptic drug -which would be a profound public health improvement.

PI_NAMEs: BOHM, RUDOLF  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Alleles;American;anti-epileptic agents;ATP1A2 gene;Biochemical;Biological;Biological Assay;Brain region;Carbamazepine;Cell Separation;Cells;Cellular biology;Childhood;childhood epilepsy;Clustered Regularly Interspaced Short Palindromic Repeats;common treatment;Development;Diagnosis;Disease;DNA Sequence Alteration;Drosophila genus;Drug Targeting;early onset;electrical property;Enhancers;Epilepsy;epileptic encephalopathies;Epileptogenesis;Epitopes;Equilibrium;Exons;experience;experimental study;fly;Future;Generations;Genes;Genetic;genome editing;Genomics;Goals;graduate student;HCN1 gene;Health;Hour;Human;human disease;improved;Individual;individualized medicine;insight;Investigation;Ion Channel;knock-down;Lead;Learning;Lethargies;Liver Failure;Maps;Mental Depression;Methods;Modeling;mosaic;Mosaicism;mutant;Mutation;Nervous System Trauma;Neurons;Normal tissue morphology;Organism;Orthologous Gene;Outcome;Phenytoin;Predisposition;Prevalence;Prevention;Process;Property;prospective;Proteins;Proteomics;Public Health;Pump;Reading Frames;recombinase;remediation;Research;Resolution;RNA-Binding Proteins;Role;Science;Seizures;side effect;skills;Students;System;targeted treatment;Testing;therapy development;Time;Tissues;transmission process;undergraduate student;Underrepresented Populations;usability;valproate;Variant

PROJECT_TITLE: CRISPR Generated Genomic Templates to Evaluate Epileptogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Chronic Pain;Fibromyalgia;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: FLUSHING

ORG_NAME: QUEENS COLLEGE

ORG_STATE: NY

PHR: NARRATIVE Chronic pain is a disabling condition that is accompanied by neuropsychiatric comorbidities such as anxiety, depression, and cognitive decline. While the peripheral alterations are well-studied, we lack an understanding of how these peripheral changes can result in long-lasting brain alterations and the ensuing behavioral phenotypes. Using a well-characterized mouse model of peripheral neuropathy, we propose to test the hypothesis that changes in brain vascular anatomy and function are major factors controlling supraspinal neuronal and glial plasticity that is a hallmark of chronic pain.

PI_NAMEs: TAJERIAN, MARAL  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Address;Adult;Affect;affective disturbance;Anatomy;Animals;Anxiety;aqueous;Area;behavior test;Behavioral;Behavioral Assay;behavioral phenotyping;Biochemical;Biological Markers;Biomedical Research;Black Box;Blood Vessels;blood-brain barrier permeabilization;Brain;brain circuitry;Cells;Central Nervous System;central pain;cerebrovascular;Cerebrovascular system;chronic pain;Clinic;cognitive function;college;comorbidity;Complex Regional Pain Syndromes;Data;Dendrites;design;Diagnostic;Disabling condition;Education;Event;experience;experimental study;Female;Fibromyalgia;Goals;Hippocampus;Histologic;Immunohistochemistry;Impaired cognition;in vivo;Individual;injured;Injury;Interdisciplinary Study;Laser Speckle Imaging;Limb structure;Masks;Mental Depression;Mental disorders;Methods;Microfils;Migraine;Molecular;mouse model;Mus;nerve injury;Neuroglia;Neurons;Neuropathy;neuropsychiatry;novel strategies;novel therapeutics;Operative Surgical Procedures;Opioid;Pain;pain chronification;pain patient;pain perception;painful neuropathy;Patients;Perfusion;Peripheral;Peripheral Nervous System Diseases;Permeability;Pharmacotherapy;Physiological;Population;prevent;Proliferating;psychiatric comorbidity;Publishing;Reporting;Research;Research Infrastructure;Research Project Grants;Resistance;Resources;Sensory;skill acquisition;Societies;spared nerve;Students;Surface;System;Techniques;Testing;Time;Tissues;tomography;tool;Tracer;Trauma;Underrepresented Minority;Vascularization;Viral;Western Blotting;Work

PROJECT_TITLE: Brain Vascular Plasticity in the Context of Peripheral Painful Trauma


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: Antibodies are invaluable in basic biomedical research and biotechnology, but lack chemical features that facilitate enzyme inhibition, covalent target engagement, and other function-disrupting bioactivities. This program seeks to advance the yeast-based biosynthesis and high throughput screening of “chemically expanded” antibodies. Our investigations will lead to inhibitors for studying how cells move, interact with their surroundings, and signal with one another while also revealing crucial principles of protein biosynthesis and enzyme inhibitor discovery.

PI_NAMEs: VAN DEVENTER, JAMES ALLEN (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Amino Acids;Anabolism;Antibodies;Antibody Diversity;antibody libraries;Binding Proteins;Biomedical Research;Biotechnology;cell type;Cells;Chemicals;Chemistry;design;Engineering;Enzyme Inhibition;Enzyme Inhibitor Drugs;Escherichia coli;Generations;Genetic;Genetic Code;Genomics;high throughput screening;human disease;Hybrids;improved;inhibitor;Investigation;Mammalian Cell;Mediating;Metalloproteases;Molecular;molecular recognition;Organism;Positioning Attribute;programs;Protein Biosynthesis;Protein Tyrosine Phosphatase;Proteins;Reagent;Research;Side;Signal Transduction;small molecule;success;Surface;synthetic antibodies;System;tool;Translations;Work;Yeasts

PROJECT_TITLE: Leveraging the yeast surface as a platform for inhibitor discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Complementary and Integrative Health;Eating Disorders;Mental Health;Mental Illness;Nutrition;Prevention

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Interoceptive skills serve a critical function to human health and well-being. Using novel quantitative approaches, this research will advance public health knowledge by addressing the current limitations in the measurement of interoception to strengthen the validity of a widely adopted tool for examining interoceptive sensibility in the context of mind-body interventions. The project will also contribute new information about how the dimensions of interoceptive sensibility interact to create a typology of interoceptive skills and deficits that can ultimately be used to predict distal health outcomes.

PI_NAMEs: MENSINGER, JANELL LYNN (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Adopted;Adult;advanced analytics;Age;Algorithms;analytical method;Area;Attention;Awareness;Behavior;Behavior Therapy;biological sex;Biological Testing;Body Image;Body mass index;Brain;Censuses;Characteristics;Clinical Psychology;Cognition;comparison group;Complex;Data;Demographic Factors;design;Development;Diagnostic;Diagnostic Factor;dimension reduction;Dimensions;Disease;disorder risk;Distal;doctoral student;Drops;Eating;Eating Behavior;Eating Disorders;emotion regulation;Emotional;endophenotype;Ensure;Etiology;Evaluation;experience;Factor Analysis;Feeling;Gender;Goals;Health;health knowledge;High-dimensional Modeling;Hispanic-serving Institution;Human;improved;Interoception;Intervention;intervention effect;Intervention Studies;Measurement;Measures;Mental disorders;Mental Health;Methods;Mind-Body Intervention;mind/body;Minor;Modeling;Modification;next generation;novel;Outcome;Patient Self-Report;person centered;Personal Satisfaction;Persons;Phenotype;physical conditioning;Play;Population;Population Heterogeneity;Procedures;Process;Property;prototype;Psychometrics;Psychopathology;psychosocial;Public Health;Questionnaires;Regulation;Reporting;Research;Resources;response;Risk Factors;Role;Sampling;screening;Signal Transduction;skills;Structure;student training;Surveys;Techniques;Testing;theories;tool;trait;Trauma;traumatic stress;Trust;Typology;Universities;Work

PROJECT_TITLE: Optimizing the Validity of the Multidimensional Assessment of Interoceptive Awareness to Predict Disordered Eating

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-8 (SU)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE How the complexity of the brain emerges during development remains a long-standing yet poorly understood question in developmental biology. With this proposal, we will seek to integrate several cutting-edge molecular and cellular tools, such as DNA memory devices and 3D cell culture models of the developing human brain, to record the developmental signals that govern brain organogenesis at a previously inaccessible resolution and scale. The successful completion of this proposal will provide an unprecedented look into the programs underlying human brain assembly and pave way to novel therapeutic opportunities in tissue repair, cancer, and neurodevelopmental disorders.

PI_NAMEs: BIREY, FIKRI  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3D Print;Address;Affect;analytical tool;Area;Atlases;Bar Codes;Biochemistry;Biomechanics;Biosensor;Bone Morphogenetic Proteins;Brain;Brain region;Callithrix;Cell Differentiation process;cell fate specification;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;congenital brain disorder;Coupled;CRISPR screen;deep learning;design;Development;Developmental Biology;developmental genetics;developmental neurobiology;Devices;Disease;DNA;DNA sequencing;Engineering;fetal;FGF8 gene;Fibroblast Growth Factor;Gene Expression Profile;Genetic;Genome;Genomics;Goals;Health;Human;human induced pluripotent stem cells;Image;Individual;insight;interdisciplinary approach;Ligands;Malignant Neoplasms;mechanotransduction;Mediating;Memory;Modeling;Molecular;Morphogenesis;morphogens;multidimensional data;nerve stem cell;neural;Neurodevelopmental Disorder;notch protein;novel therapeutics;Optics;Organogenesis;Organoids;Pathway interactions;Pharmacology;Physiological;Primates;prime editing;Process;progenitor;programs;Protocols documentation;Recording of previous events;recruit;Research;Resolution;response;Role;Running;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;Specificity;stem cell organoids;stem cells;Stratification;Structure;synthetic biology;System;Techniques;temporal measurement;Therapeutic Effect;three dimensional cell culture;Time;Tissue Engineering;tissue repair;tissue-level behavior;Tissues;tool;transcriptomics;Transforming Growth Factor beta;transmission process;Tretinoin

PROJECT_TITLE: Elucidating the Signaling Landscapes Underlying Cellular and Regional Specification During Human Brain Development

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Genetics;Infertility

ORG_CITY: LAS CRUCES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE In this project we will determine the role of the non-canonical polyA polymerase TENT5 in spermatogenesis in the fruit ﬂy Drosophila melanogaster. A TENT5 gene has been linked to infer�lity in human males and our research ﬁndings will increase our understanding about causes and treatment of human male infer�lity.

PI_NAMEs: CURTISS, JENNIFER R (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Affect;Alleles;Animals;Binding;Caenorhabditis elegans;Caspase;Catalytic Domain;cell type;Cells;Coupling;CRISPR/Cas technology;Data;Defect;Development;Drosophila genus;Drosophila melanogaster;egg;Excision;experimental study;Family;Family member;Fluorescent in Situ Hybridization;Future;Genes;Genetic;Genetic Transcription;Germ Lines;Giant Cells;Homeostasis;Human;human disease;human male;Immunoprecipitation;In Situ Hybridization;Individual;knock-down;Life Cycle Stages;Link;loss of function;loss of function mutation;Male Infertility;Male Sterility;Mammals;Maternal Messenger RNA;Meiosis;member;Messenger RNA;mRNA capping;mRNA Translation;Mus;mutant;Natural regeneration;neuronal cell body;Oocytes;Organism;Orthologous Gene;Pathway interactions;Pattern;Phenotype;Play;Poly A;Polyadenylation;Polymerase;Process;Progesterone;protein function;Protein Isoforms;Proteins;Repression;Research;RNA;RNA Interference;Role;single molecule;Spermatids;Spermatogenesis;Sterols;System;Tail;Techniques;Testis;Time;tool;trafficking;Translational Activation;Translational Repression;Translations;Vertebrates;Xenopus;Xenopus laevis;Xenopus oocyte

PROJECT_TITLE: Determining the role of a TENT5 family non-canonical polyA polymerase in Drosophila spermatogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: KENNESAW

ORG_DEPT: CHEMISTRY

ORG_NAME: KENNESAW STATE UNIVERSITY

PHR: Project Narrative Pseudomonas aeruginosa is the cause of most hospital-acquired infections, infecting more than two million people annually and resulting in almost 90,000 deaths. Notably, the environmental versatility of P. aeruginosa, its multiple mechanisms for antibiotic resistance, and its wide range of dynamic defenses (e.g., biofilm formation), render it a most challenging organism to effectively treat. Understanding the proteins that regulate these processes (e.g., transcription factors) will illuminate new pathways and targets for the development of anti-P. aeruginosa therapeutics.

PI_NAMEs: VAN DYKE, MICHAEL W (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Aerobic;Affinity;Affinity Chromatography;Antibiotic Resistance;Antibiotics;Applied Skills;Award;Bacteria;Basic Science;Binding;Binding Sites;Bioinformatics;Biological;Biological Assay;Biological Process;Biology;career;Cessation of life;Clinical;Consensus;cystic fibrosis patients;Data;Development;DNA Binding;DNA Restriction Enzymes;Education;Environment;environmental change;Escherichia coli;Family;Fresh Water;Funding;Gene Expression;Gene Family;Genes;genetic approach;Genetic Transcription;Genome;Goals;graduate student;Grant;Health;Heavy Metals;Homologous Gene;Hospitals;Human;Immobilization;Immunocompromised Host;In Vitro;in vivo;Individual;Industry;insight;Interferometry;Knowledge;Laboratories;Libraries;Mediating;Metals;Methods;Microbial Biofilms;Minority-Serving Institution;Morbidity - disease rate;mortality;mutant;next generation sequencing;Nosocomial Infections;novel;Operon;opportunistic pathogen;Organism;Oxidative Stress;pathogen;Pathogenesis;Pathway interactions;Persons;Process;Prokaryotic Cells;promoter;Proteins;Pseudomonas aeruginosa;Regulatory Pathway;Research;Research Activity;Research Support;response;reverse genetics;Rod;Role;Schools;Shapes;Site;Specificity;stem;Stimulus;Streptococcus thermophilus;student training;success;Therapeutic;Therapeutic Intervention;Thermus thermophilus;training opportunity;transcription factor;transcription regulatory network;undergraduate student;United States National Institutes of Health;Virulence

PROJECT_TITLE: Transcription Factor Discovery in the Opportunistic Pathogen Pseudomonas aeruginosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: The goal of the U-RISE Program at the University of Puerto Rico Rio Piedras campus (UPR-RP) is to support educational and research activities that will enhance the diversity and quality of the biomedical and research workforce at UPR-RP. This will be done by means of supporting capacity building activities with a primary focus on achieving a continuous research experience as well as workshops and seminars designed to improve the students’ professional skills. We are expecting to deliver the next generation of a well-qualified biomedical workforce.

PI_NAMEs: CARBALLEIRA, NESTOR MANUEL (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: URISE at the University of Puerto Rico Rio Piedras

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients fail to recover because we do not understand the mechanisms underlying successful response, leading to significant variability in how clinicians conduct exposure therapy. Using machine learning to analyze patient data from real-world treatment, the current study will determine which exposure mechanisms lead to favorable clinical outcomes and what makes a good exposure for whom. Results of this study have the potential to improve personalized care for the many patients who do not remit following exposure therapy for OCD.

PI_NAMEs: KUCKERTZ, JENNIE M (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Adult;Algorithms;Anxiety;anxiety sensitivity;Behavior;Behavioral;Caring;Characteristics;Clinical;Collaborations;Continuity of Patient Care;coping;Data;Disease;effective therapy;Expectancy;Exposure to;Favorable Clinical Outcome;Feedback;Fright;Future;Galvanic Skin Response;Goals;habituation;Heart Rate;heart rate variability;Hospitals;improved;improved outcome;Individual;innovation;insight;Judgment;Knowledge;Lead;Learning;learning outcome;Left;Machine Learning;machine learning prediction;Measures;Mental Depression;Methods;Modeling;Monitor;National Institute of Mental Health;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Outcome;outcome prediction;Outpatients;Participant;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;personalized care;personalized intervention;personalized medicine;Persons;Physiological;Physiology;Pilot Projects;predict clinical outcome;predictive modeling;Predictive Value;Randomized;Regulation;Reporting;Research;response;Sampling;Self Efficacy;Sex Orientation;sexual minority;Site;Symptoms;Testing;Theoretical model;theories;therapeutic target;Time;Translating;treatment choice;Treatment Failure;treatment program;treatment research;treatment response;Universities;wearable device;Work

PROJECT_TITLE: Leveraging Machine Learning Approaches to Understand Mechanisms of Exposure Therapy in Real-World Settings

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY STATE UNIVERSITY

PHR: Estrogen-related receptor (ERR) is a new target to combat a few types of breast cancers. Inverse agonists (anti- cancer drug) can inhibit the activity of ERR, and reduce the proliferation and migration of cancer cells. The proposal will aim to provide new understanding for eventually developing more efficient inverse agonists.

PI_NAMEs: WANG, YIXUAN  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 3-Dimensional;Affinity;Agonist;Amines;Antineoplastic Agents;Binding;Binding Proteins;Breast Cancer therapy;Breast Cancer Treatment;cancer cell;cancer diagnosis;Cancer Etiology;combat;Complex;Data;density;Development;Drug Design;ERR1 protein;Estrogen Activity Inhibition;estrogen-related receptor;Free Energy;Genes;Genetic Transcription;Goals;Hot Spot;Hydrogen Bonding;Hydrophobicity;insight;Ligand Binding;Ligand Binding Domain;Ligands;Malignant Breast Neoplasm;Methods;migration;Molecular Conformation;molecular dynamics;molecular mechanics;molecular scale;Play;Proliferating;Proteins;Quantum Mechanics;Reporting;Role;Scheme;Structure;System;targeted treatment;Testing;theories;Thermodynamics;transcription factor;tumor;United States;Update;Visualization software;Women's mortality

PROJECT_TITLE: Comprehensive understanding about the binding of estrogen-related receptor alpha (ERR-α) to inverse agonists with the first-principles based theoretical methods


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Center for Cellular Adaptation at the University of Chicago is undertaking a comprehensive project to understand the fundamental processes that enable cells to adapt to changes in their environment, which could lead to innovative therapeutic interventions for a wide range of diseases. The research involves three main thrusts: investigating how cells adapt on very short timescales (from milliseconds to minutes) by changing the location and activity of proteins, understanding how cells adapt on longer time scales (minutes to days) by adjusting the activity of their genes, and studying adaptation on the even longer time scales of multi-generational inheritance (days to years). Through this collaborative, multiscale approach, the team aims to provide a unified framework that links adaptive processes on physiological and evolutionary timescales, potentially reshaping our understanding of cellular maladaptation in aging, cancer, and neurodegeneration.

PI_NAMEs: BASU, ANINDITA ;MANI, MADHAV ;OAKES, SCOTT A.;PINCUS, DAVID  (contact);SQUIRES, ALLISON HOLMES

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Aging;biological adaptation to stress;Biophysics;Buffers;Businesses;Cancer cell line;Candida albicans;Cell model;Cell Physiology;Cells;Cellular biology;Chalk;Characteristics;Chicago;Collaborations;Complex;Consensus;Coupled;CRISPR interference;Data;Data Scientist;dimension reduction;Disease;DNA Sequence Alteration;Environment;environmental adaptation;environmental change;environmental stressor;Evolution;Exposure to;Feedback;fitness;Funding;Future;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Epistasis;Genetic Transcription;genetic variant;Genetic Variation;genome-wide;Goals;Growth;Heritability;Homeostasis;Hour;Individual;Information Theory;innovation;Investigation;Link;Location;Logic;loss of function;macromolecule;Malignant - descriptor;Malignant Neoplasms;Maps;materials science;Measures;Mediating;meetings;Membrane;Methods;millisecond;Modeling;Molecular Chaperones;multimodality;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;novel;pancreatic cancer cells;Pathology;Phenotype;Physical condensation;physical property;Physiological;Physiological Adaptation;Physiology;Population;preservation;Process;programs;Property;protein aggregation;Proteins;Proteomics;Publications;Recording of previous events;Repression;Research;response;Role;Saccharomyces cerevisiae;screening;Series;Shapes;Signal Transduction;single-cell RNA sequencing;Stress;stressor;Structure;Surveys;synergism;Testing;Therapeutic Intervention;Time;transcriptome;transcriptomics;Universities;Yeasts

PROJECT_TITLE: Multimodal Investigation of Cellular Adaptation Across Timescales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (50)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative In this project we will determine the roles of specialized white blood cells, called chimeric antigen receptor (CAR) T cells, in promoting an immune response against tumors and reduction of toxicity in mice when combined with an FDA-approved anti-inflammatory drug and determining their potential for use in cancer adoptive cell immunotherapy. We hypothesize that transfer of these tumor-killing CAR T cells will eradicate established tumors and prevent recurrence in vivo in both mouse and human tumor models, due to their ability to 1) directly kill the tumor cells; 2) reprogram macrophage to facilitate host antitumor immune responses, and 3) reprogram macrophage to reduce toxicities.

PI_NAMEs: LU, YONG  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: acute toxicity;Adoptive Cell Transfers;Adoptive Immunotherapy;Anti-Inflammatory Agents;anti-tumor immune response;Antigen Targeting;Antigens;Aryl Hydrocarbon Receptor;Automobile Driving;B lymphoid malignancy;CAR T cell therapy;CD19 gene;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic graft versus host disease;Clinic;Clinical;Clinical Management;Clinical Trials;Coculture Techniques;cohort;complement C2a;cytokine;cytokine release syndrome;Disease;Dose;Double-Stranded RNA;ds-DNA;Event;FDA approved;Foundations;Future;Heterogeneity;Human;Immune;immune effector cell-associated neurotoxicity syndrome;Immune response;improved;in vivo;Inflammatory;Interferon alpha;Interleukin-1;Interleukin-6;Leprosy;Leukocytes;Literature;Lymphoma;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mechanics;Modeling;Monoclonal Antibodies;mortality;Mus;NADPH Oxidase;neoplastic cell;NF-kappa B;novel;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;prevent;Prevention;Production;programs;Reactive Oxygen Species;Receptor Signaling;Recurrence;Relapse;Reporting;response;Role;screening;side effect;Signal Transduction;SKOV3 cells;Solid Neoplasm;T-Lymphocyte;Testing;Therapeutic;tocilizumab;Toxic effect;tumor;Tumor Antigens;tumor eradication;Tumor Immunity;tumor xenograft;Up-Regulation;Work

PROJECT_TITLE: Decoupling acute toxicities and antitumor efficacy in adoptive cell therapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The preschool years are a sensitive period for the development of self-regulatory skills and reward-related brain activity that support socioemotional development. Maternal socialization of positive emotion is one important influence on development of reward-related brain activity in children, both of which can be impaired by maternal depression. To better understand how reward-related brain activity develops in the context of parenting, we will examine how maternal coaching of positive emotion in children of depressed mothers influences in-the-moment reward-related brain response.

PI_NAMEs: BYLSMA, LAUREN M;MORGAN, JUDITH K. (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 6 year old;active control;Affect;Arousal;Behavior;behavior change;Brain;caregiving;Characteristics;Child;Child Rearing;Clinical;clinically significant;depressive symptoms;Development;early childhood;Emotional;Emotions;Environment;Event-Related Potentials;Exhibits;Feedback;Female;Fostering;Goals;Impairment;in vivo;Intervention;Investigation;Learning;life span;Link;Maternal Behavior;maternal depression;Mediating;Mental Depression;Methodology;Mothers;Motivation;neural;Nursery Schools;offspring;Parent-Child Relations;parenting intervention;Parents;Patient Self-Report;Play;pleasure;positive emotional state;Preschool Child;preventive intervention;Randomized;Recording of previous events;response;reward circuitry;Rewards;Risk;School-Age Population;showing emotion;skills;social;Socialization;socialization behavior;Stimulus;sustained attention;Testing;Therapeutic Intervention;Time;Training;trial design;Well in self

PROJECT_TITLE: Maternal Positive Affect Socialization and Child Neural Reward Response

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative - Overall This Phase II Center of Biomedical Research Excellence (COBRE) proposal aims to sustain and enhance a research center focused on molecular and cellular signal transduction in the cardiovascular system within the University of Nevada, Reno. The research mission of this Center is significant because cardiovascular diseases remain the leading causes of death and disability in the US and much of the world. The Center’s research is expected to reveal novel concepts that lead to new treatments for these conditions.

PI_NAMEs: HARVEY, ROBERT D (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acceleration;Animal Model;aspirate;Back;Basic Science;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;career;career development;Cause of Death;Cell Physiology;Cell Surface Receptors;Centers of Research Excellence;cohort;Collaborations;collaborative environment;college;common treatment;Communities;Coupling;Development;disability;Disease;Endothelial Cells;Environment;Epigenetic Process;Equipment;Foundations;Funding;Genotype;Goals;Grant;Health;Human;Image;improved;innovation;insight;Interdisciplinary Study;interest;Ion Channel;Journals;Leadership;Link;Medical;Medicine;member;Mentors;Mission;Molecular;multidisciplinary;Neurons;Nevada;novel;Pathology;peer coaching;Pharmacology;Phase;Phenotype;Pilot Projects;Positioning Attribute;Principal Investigator;Productivity;professor;Program Development;Program Research Project Grants;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Scientist;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Smooth Muscle Myocytes;Solid;success;Teacher Professional Development;Technology;temporal measurement;therapeutic development;Transgenic Animals;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular

PHR: Project Narrative – Core A The goal of this proposal is to sustain and enhance the Administrative and Faculty Development Core (Core A) of a Phase II Center of Biomedical Research Excellence (COBRE) that is focused on molecular and cellular signal transduction in the cardiovascular system within the University of Nevada, Reno (UNR). Core A houses the infrastructure to manage administrative, fiscal, and scientific aspects of the COBRE; execute a Faculty Development Plan to promote the rapid development of the COBRE’s Research Project Leaders (RPLs) from early-stage investigators to fully independent research scientists; continuously track and evaluate the progress of RPLs to scientific independence; establish and execute a Pilot Projects Program; and track and assess the success of the Research Cores.

PI_NAMEs: EARLEY, SCOTT  (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;base;Basic Science;Cardiovascular Physiology;Cardiovascular system;career;career development;Centers of Research Excellence;Collaborations;design;Development;Development Plans;Disease;Ensure;Evaluation;experience;Faculty;formative assessment;Funding;Goals;Health;Individual;Infrastructure;Institution;Interdisciplinary Study;International;Journals;Leadership;medical schools;meetings;member;Mentors;Methods;Molecular;Monitor;multidisciplinary;Nevada;novel;Office of Administrative Management;peer coaching;Pharmacology;Phase;Pilot Projects;Principal Investigator;professor;Program Development;programs;Publications;recruit;Regulation;Research;research and development;Research Personnel;Research Project Grants;Research Support;Scientist;Signal Transduction;Structure;success;Teacher Professional Development;United States National Institutes of Health;Universities

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Genetics;Heart Disease

PHR: Project Narrative Cardiovascular disease is the number one cause of death in the USA and globally. This proposal will establish a state-of-the-art facility and technologies to support scientific research in this area. Successful operation of the proposed Core is expected to provide an infrastructure that is key to the success of cardiovascular research and facilitate the development of novel drugs for the treatment of cardiovascular diseases.

PI_NAMEs: FENG EARLEY, YUMEI  (contact)

PROJECT_TERMS: Abdomen;Animal Model;Animals;Aorta;Area;Behavioral;Biosensor;Blood Pressure;Blood Pressure Monitors;blood pressure regulation;Blood Vessels;Body Weight;Breeding;Cardiac;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Centers of Research Excellence;Collection;Conscious;Core Facility;CRISPR/Cas technology;Database Management Systems;Development;Dimensions;disease model;Eating;Echocardiography;embryonic stem cell;Energy Metabolism;Equipment;Faculty;Funding;Gene Modified;Generations;Genetic;Genetically Modified Animals;Genotype;Goals;heart function;Heart Rate;hemodynamics;Hypertension;in vivo;Indirect Calorimetry;Infrastructure;Injections;Intervention;Investigation;Kidney;Knock-out;Knockout Mice;Laboratories;Laboratory Animals;Maintenance;Measurement;member;Metabolic;metabolic phenotype;Methods;Mission;Modification;Molecular;Monitor;Motor Activity;mouse model;Mus;Nevada;novel;novel therapeutics;operation;pharmacologic;Phase;Phenotype;Procedures;programs;Protocols documentation;Qualifying;Rattus;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Services;Signal Transduction;Signal Transduction Pathway;Solid;Standardization;success;Supervision;Techniques;Technology;Telemetry;Thick;Training;Transgenic Animals;Transgenic Mice;Transgenic Organisms;ultrasound;United States National Institutes of Health;Universities;Vendor;Ventricular Function;Water consumption

PROJECT_TITLE: Core B - Transgenic Animal Genotyping and Phenotyping Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular

PHR: Project Narrative – High Spatial and Temporal Resolution Imaging (HSTRI) Core (Core C) We propose to expand the services offered by the High Spatial and Temporal Resolution Imaging (HSTRI) Core established during Phase I COBRE with the goal of providing instrumentation and scientific expertise that will enable COBRE Project Leaders to perform crucial experiments that are not possible in their individual laboratories. With the assistance of expert staff and unrestricted access to these instruments, we expect the HSTRI Core to greatly enhance the competitiveness of Project Leaders in future grant applications and promote their recognition and contribution to their respective field at the international level, both of which will accelerate the pace of discovery. This facility is specifically designed to meet the needs of our Project Leaders but will also enhance the overall capacity for research by serving as a campus wide infrastructure to assist researchers at the University of Nevada, Reno, and the UNR School of Medicine.

PI_NAMEs: LEBLANC, NORMAND  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Administrative Supplement;Applications Grants;Award;base;biological systems;Biomedical Research;Biosensor;Businesses;Cardiovascular system;Cells;Cellular Structures;Centers of Research Excellence;Communities;Computer Analysis;Computer software;Core Facility;Coupled;COVID-19 pandemic;cryostat;design;Development;Disease;Educational workshop;Engineering;Equipment;experimental study;Fees;Fluorescence Resonance Energy Transfer;Foundations;Funding;Future;Generations;Goals;Grant;Health;high end computer;high resolution imaging;Human Resources;Image;Image Analysis;imaging approach;imaging capabilities;imaging modality;imaging system;Individual;Infrastructure;Institution;instrument;instrumentation;International;Investments;Label;Laboratories;Lasers;Licensing;Light;medical schools;member;Methodological Studies;Microscope;Microscopy;Microtome - medical device;Molecular;Nevada;new technology;novel;operation;Paper;patch clamp;Performance;pharmacologic;Pharmacology;Phase;Pilot Projects;Preparation;Research;Research Personnel;Research Project Grants;Sampling;Scanning;Services;Signal Pathway;Signal Transduction;Structure;success;Supervision;System;Technology;temporal measurement;Tissue Sample;Tissues;Training;ultra high resolution;Universities;Visualization

PROJECT_TITLE: Core C - High Spatial and Temporal Resolution Imaging Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Neurosciences

PHR: Project Narrative The sympathetic nervous system, the “fight of flight” branch of the autonomic nervous system, plays a key role in modulating cardiac output. Sympathetic overactivity during disease states such as heart failure contributes to disease pathology; however, the molecular mechanisms that contribute to this overactivity are largely unknown. In this project we propose to use high-resolution single-molecule imaging techniques to investigate the dynamic regulation of sympathetic neurons on a molecular level as an avenue to develop novel therapeutic interventions.

PI_NAMEs: AKIN, ELIZABETH  (contact)

PROJECT_TERMS: Afferent Neurons;Applications Grants;Autonomic nervous system;Axon;Axonal Transport;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiovascular Diseases;Cardiovascular system;Cells;Centers of Research Excellence;Characteristics;Chronic;Clinical;Coculture Techniques;Collaborations;cytokine;Development;Disease;Disease Progression;Dominant-Negative Mutation;experimental study;fighting;Foundations;Future;Heart failure;high resolution imaging;Image;Imaging Techniques;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-6;Kinesin;Knowledge;LIF gene;live cell imaging;Mediating;Microfluidics;Modeling;Molecular;Molecular Motors;Monitor;Morbidity - disease rate;mortality;Motor;Muscle Cells;neonatal mice;Neurons;neuropeptide Y;Neuropeptides;neurotransmission;Neurotransmitters;Nevada;Norepinephrine;novel;novel imaging technique;novel therapeutic intervention;Optics;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Physiologic pulse;Plasma;Play;prevent;Process;Prognosis;protein transport;Proteins;rab GTP-Binding Proteins;Regulation;Reporting;Research Design;Resolution;response;Signal Transduction;single molecule;Sodium Channel;sudden cardiac death;Surface;Survival Rate;Sympathetic Nervous System;Synapses;synaptogenesis;System;Testing;Therapeutic Intervention;Tissues;TNF gene;trafficking;Transfection;translational study;treatment strategy;United States National Institutes of Health;Ventricular;Vesicle;Visualization;voltage;Withdrawal;Work

PROJECT_TITLE: Project 6 - Molecular regulation of sympathetic neuron activity in cardiovascular disease


PHR: Narrative  Inflammation contributes to the pathogenesis of many leading causes of mortality, including heart disease and  associated pathologies such as ischemia-reperfusion injury. Neutrophils adhere to the vessel wall through  extracellular matrix interactions mediated by integrin and spread before migrating to sites of inflammation. It has  been shown that manipulating neutrophil adhesion is beneficial in various pathological settings, including  transplantation and inflammatory bowel diseases, among others. Here, we propose to investigate the  fundamental integrin activation mechanism that drives neutrophil adhesion in inflammation. Completion of this  study is expected to provide key insights into cell adhesion mechanisms and facilitate the development of novel  drugs targeting inflammation.  2

PI_NAMEs: WEN, LAI  (contact)

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Adaptor Signaling Protein;Address;Adhesions;Affinity;Antibodies;Area;Attenuated;Bacterial Infections;Binding;Blood Circulation;Blood flow;Cardiovascular system;Cell Adhesion;Cell Line;Cell membrane;cell type;Cells;Centers of Research Excellence;chemokine;Chimeric Proteins;conditional knockout;Coronary Arteriosclerosis;cremaster muscle;CRISPR/Cas technology;Cytoplasmic Protein;Cytoplasmic Tail;Cytoskeleton;Data;Detection;Development;Disease;driving force;Endothelial Cells;Endothelium;Engineering;Exposure to;Extracellular Domain;Extracellular Matrix;F-Actin;fluorescence imaging;Future;Heart Diseases;Hematopoietic;HL-60 Cells;HL60;Host Defense;Human;Hypertension;IL8 gene;Image;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;innovation;insight;Integrin beta Chains;Integrin Binding;Integrins;intravital imaging;ischemic injury;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Leukocytes;Ligand Binding;Mediating;Microfluidics;migration;Modeling;Molecular;Molecular Conformation;Monitor;Monoclonal Antibodies;mortality;mouse model;Mus;Mutate;Mycoses;necrotic tissue;neutrophil;Neutrophil Infiltration;Nevada;new therapeutic target;Pathogenesis;Pathologic;Pathology;PH Domain;Physiological;Play;Process;recruit;Reperfusion Injury;Reporter;Reporting;Research;response;Role;Signal Transduction;Site;spatiotemporal;Stroke;Structure;Talin;Tertiary Protein Structure;Testing;Tissues;tool;translational study;Transmembrane Domain;Transplantation;vascular inflammation;Work

PROJECT_TITLE: Integrin activation during neutrophil adhesion and vascular inflammation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PHR: Project Narrative The sinoatrial node is the pacemaker center of the heart and is responsible for generating every heartbeat that we produce during our lifetimes. To sustain the constant electrical signal generation, blood vessels supply oxygen and nutrients to the sinoatrial node that allow it to function normally. During a disease known as heart failure, the sinoatrial node undergoes many changes to its structure and function. This project will investigate how blood flow to different regions of the sinoatrial node is regulated and how flow can change as a result of exercise and heart disease.

PI_NAMEs: GRAINGER, NATHAN  (contact)

PROJECT_TERMS: Action Potentials;Adrenergic Receptor;Affect;Aging;Agonist;aorta constriction;Arteries;arteriole;atrioventricular node;Autonomic nervous system;Blood;Blood capillaries;Blood flow;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular system;cell type;Centers of Research Excellence;Circulation;Clinical;Coronary;Coronary artery;Coupling;density;Disease;electrical property;Endothelial Cells;Ensure;Event;Exercise;Exhibits;Fluorescent in Situ Hybridization;Frequencies;Future;Generations;Genetic Complementation Test;Goals;Health;Heart;Heart Atrium;Heart Diseases;Heart failure;Heart Rate;Heterogeneity;Impairment;improved;In Situ;Inferior;interstitial;Link;Lung;Maps;Mediating;Metabolic;Molecular;Monitor;mouse model;Mus;Muscle Cells;Myocardial;Nerve;nerve supply;Nevada;new therapeutic target;Nodal;Norepinephrine;novel;Nutrient;optogenetics;Outcome;Oxygen;Pacemakers;Pathway interactions;Pattern;Perfusion;Pericytes;Periodicity;Physiological;Positioning Attribute;Preparation;pressure;Pump;receptor;Regulation;Resolution;response;Rest;Right ventricular structure;Sick Sinus Syndrome;Signal Transduction;Sinoatrial Node;Site;Smooth Muscle Myocytes;spatial relationship;Structure;Sympathetic Nervous System;Testing;tissue fixing;Tissue imaging;Variant;Vascular resistance;Vascular Smooth Muscle;Vascularization;Work

PROJECT_TITLE: Project 8 - Autonomic regulation of coronary blood flow in the superior and inferior sinoatrial node


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

ORG_STATE: CA

PHR: Project Narrative  The brain enjoys metabolic and immunological privileges due to the presence of the blood brain barrier, a formidable barricade composed of brain microvasculature endothelial cells that have cholesterol-rich tight junctions (TJs). It is not known if the central nervous system or the vasculature provides cholesterol to the TJs under normal and under conditions of heightened oxidative stress such as those noted with aging. The goal of the proposal is to define the role of high-density lipoprotein and apolipoprotein E (both recognized as cholesterol transporters) in supplying cholesterol to the TJs using a combination of biochemical, cell biological and mass spectrometric tools.

PI_NAMEs: NARAYANASWAMI, VASANTHY  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 4 hydroxynonenal;Address;Affect;age related;Aging;Aldehydes;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Antiatherogenic;Apical;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Behavior;Biochemical;Biological;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;California;candidate identification;cardiovascular risk factor;career;Cells;Central Nervous System;cerebral microvasculature;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;Coculture Techniques;Complement;Complex;Data;Data Analyses;Data Collection;Endothelial Cells;Experimental Designs;Family;Flow Cytometry;fluorescein isothiocyanate dextran;Fluorescence;Fluorescence Microscopy;Goals;graduate student;hallmarks of aging;high density lipoprotein-apolipoprotein E;High Density Lipoproteins;Hispanic;Immunologics;Immunoprecipitation;Impairment;In Vitro;Infrastructure;innovation;insight;interdisciplinary approach;Intervention;Knockout Mice;Label;Ligands;Lipid Peroxidation;lipidomics;Lipids;Lipoprotein Receptor;Lipoproteins;liquid chromatography mass spectrometry;Manuscripts;Maps;Mass Spectrum Analysis;Mediating;Metabolic;Modeling;Molecular;Molecular Analysis;Monitor;monolayer;Mus;Neurologic;neurovascular;Oxidative Stress;Permeability;Plasma;Play;Population;Preparation;programs;Protein Isoforms;Proteins;Proteomics;receptor mediated endocytosis;Recombinants;reconstitution;Regulation;Research;Role;Route;scavenger receptor;Science;Side;Sterols;stressor;Students;symposium;Testing;Tight Junctions;Time;tool;undergraduate student;United States National Institutes of Health;Universities;uptake;Vascular System;Visualization

PROJECT_TITLE: Role Of Apolipoprotein E In Maintaining the Blood Brain Barrier Integrity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Telehealth

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Unplanned Emergency Department visits and hospitalizations are costly and burdensome to patients and the health system. Some of these visits may be preventable by appropriately monitoring high-risk patients to generate early warnings of deterioration and unmet health needs, but current research is limited in the patient populations studied, and by a lack of integration between remote monitoring and acute care. This project will produce a machine learning framework for integrating continuous home monitoring of vital signs and activity with acute care, to guide the development of monitoring and intervention strategies for patients discharged from the hospital, and the effective use of home monitoring data when patients return to the hospital.

PI_NAMEs: KIM, DAVID ANDREW (contact);RAJPURKAR, PRANAV

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Adherence;Ambulatory Care;Behavioral;Caring;Clinical;Clinical Data;clinical predictors;cohort;Data;Data Reporting;deep learning model;design;Deterioration;Development;Diagnosis;Emergency Department patient;Emergency Department Physician;Emergency department visit;Enrollment;Evaluation;Event;follow-up;Foundations;Frequencies;Goals;Health;health care service utilization;health related quality of life;Health system;high risk;Home;Home environment;Hospital Costs;Hospitals;improved;Intervention;large language model;Link;longitudinal analysis;Machine Learning;machine learning framework;machine learning model;Measurement;Modality;Modeling;Monitor;monitoring device;natural language;outcome prediction;participant enrollment;Patient Discharge;Patient Monitoring;patient population;Patient risk;patient subsets;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Population Study;predict clinical outcome;prevent;preventive intervention;prospective;Quality of life;remote monitoring;remote patient monitoring;Reporting;Research;Resources;Risk;Signal Transduction;smartphone application;Subgroup;Technology;Testing;Time;timeline;trend;Visit;wearable monitor

PROJECT_TITLE: Integrating Acute and Ambulatory Care with Post-Discharge Monitoring and Machine Learning

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative To understand the cause of diseases, scientists study cells that serve as models of those diseases. This microscope will allow scientists to study what happens inside those cells, in detail. Discoveries of mechanisms of disease could be used to find treatments and cures and will benefit public health.

PI_NAMEs: ARIEL, PABLO  (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Area;Arts;base;Biological;Charge;Communities;Comprehensive Cancer Center;Computer software;Core Facility;cost effectiveness;detector;experience;Funding;Human Resources;Image;Infrastructure;instrument;instrumentation;Laboratories;Lasers;Light;light transmission;Manufacturer;Medicine;Microscope;Microscopy;Modeling;Modernization;Motor;North Carolina;Public Health;Recording of previous events;Research;Research Personnel;Research Project Grants;Risk;Scanning;Schools;Science;Services;Source;Specimen;System;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Zeiss LSM900 laser scanning confocal microscope for the University of North Carolina at Chapel Hill

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

PHR: Project Narrative Even though successful treatments including radiation, chemotherapy and more recently targeted therapy and immunotherapy are available, the leading cause of cancer deaths in women is breast cancer. The main cause is the development of metastasis, when the primary tumor has migrated and starts to grow in distant tissues. The current research aims to develop new drugs that inhibit specific biological pathways that are involved in migration, decrease the possibility of the development of metastatic tumors and improve health outcomes for cancer patients.

PI_NAMEs: VLAAR, CORNELIS P (contact)

PROJECT_TERMS: 6-Mercaptopurine;analog;Animal Model;Antimetabolites;Autoimmune;Autoimmune Diseases;Award;Azathioprine;base;Binding;Binding Sites;Biochemical Process;Biological;Biological Products;Breast Cancer Patient;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;Carbazoles;cell motility;cell type;Cessation of life;chemotherapy;Clinical Research;Collaborations;Committee Members;Complex;covalent bond;cytotoxicity;design;Development;Disease;Disseminated Malignant Neoplasm;Distant;Docking;Doctor of Philosophy;dosage;Enzymes;Epoxy Compounds;experience;experimental study;Family;FDA approved;first-in-human;Genetic Polymorphism;genetic regulatory protein;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Hepatitis C virus;Hurricane;Hydrolysis;hydroxyl group;Immunotherapy;improved;in vivo;Inflammatory;inhibitor;instrumentation;Interruption;Intestines;Knowledge;KRAS2 gene;Label;Laboratories;Lead;leukemia;leukemia treatment;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mentors;Metabolic;Metabolic Activation;Metabolic Pathway;Metastatic breast cancer;migration;Molecular;Monomeric GTP-Binding Proteins;Mus;Neoplasm Metastasis;novel;novel therapeutics;nucleoside monophosphate;Nucleotides;Outcome;Pathway interactions;patient variability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacy Students;Phase;Phase I Clinical Trials;phosphoramidate;Phosphorylation;preclinical development;prevent;Primary Neoplasm;Prodrugs;programs;Property;Proteins;Publishing;Puerto Rico;rac1 GTP-Binding Protein;Radiation;Research;Research Project Grants;response;rho;rho GTP-Binding Proteins;Safety;Schools;Science;small molecule;small molecule inhibitor;Solubility;Students;success;Sulfhydryl Compounds;Sulfur;Syndrome;targeted treatment;Techniques;Testing;Thioguanine;thiopurine;Tissues;Toxic effect;Training;tripolyphosphate;tumor growth;undergraduate student;Universities;uptake;Women's mortality;Work

PROJECT_TITLE: Assessment of small molecules as covalent inhibitors of Rac/Cdc42

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (SU)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Foodborne Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Health Statement: Nitrite ingestion is linked to several physiological disorders in humans (hemoglobin oxidation, heart damage, endocrine disruption, etc.), but little is known about how long-term exposure to small concentrations of nitrite through drinking water affects pregnancy and embryo development. In the proposed research project, we will explore the effects of exposure to nitrite during the full gestational period, including the effects of nitrite in the maternal transfer of steroids, immune factors, and transcripts and its concomitant effects on embryo development. Ultimately our findings will lead to a deeper understanding of the mechanisms of nitrite toxicity during gestation and will help to advance guidelines for water quality parameters to be observed for consumption during pregnancy.

PI_NAMEs: HUERTAS, MAR  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acute;Address;Adolescent;Affect;Agriculture;Animal Pregnancy;Anosmia;Behavior;Brain;Brain region;Cardiac;Chronic;Cognitive;cognitive performance;Consumption;Data;Defect;design;Development;developmental immunology;Disease;drinking;drinking water;Drops;Education;egg;Elements;Embryo;Embryonic Development;Embryonic Nervous System;Endocrine disruption;Endocrinology;experimental study;Exposure to;Female;Fertilizers;Fetal Development;Fetus;Fishes;Food;Formalin;Gene Expression Profiling;Genes;Goals;Gonadal Steroid Hormones;graduate student;Growth;Growth and Development function;Guidelines;Head;Health;heart damage;Heart Diseases;Hemoglobin;Hispanic;Hispanic-serving Institution;Histologic;Human;Imaging Techniques;Immune;Immunologic Factors;Impaired cognition;Induced Neurons;Ingestion;Kidney;Knowledge;Larva;Link;malignant endocrine gland neoplasm;Maps;Measures;Methemoglobinemia;Methods;Modeling;Mothers;nervous system development;Nervous System Trauma;neural;Neurobiology;neurodevelopment;Neurologic;neuron development;Neurons;Nitrates;Nitrites;Nitrogen;offspring;olfactory bulb;Olfactory Epithelium;Organ;Outcome;Ovary;oxidation;Paraffin;Paraffin Embedding;Partner in relationship;Pathway interactions;Phase;Physiological;pollutant;Pollution;Pregnancy;pregnant;Pregnant Women;Preventive treatment;Process;Productivity;Research;Research Project Grants;Risk;Signal Transduction;skills;Slice;Source;Steroids;Stress;success;Testing;Texas;Time;tissue fixing;Tissues;Toxic effect;Toxicology;Transcript;transcriptomics;Transfer Factor;Universities;Vertebrates;wasting;Water;Water Pollutants;water quality;water sampling;Work;Xiphophorus

PROJECT_TITLE: Maternal transfer factors and offspring development defects induced by nitrite


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Relevance: The requested Elyra 7, SIM2 super-resolution microscopy system will increase our understanding of the fundamental biological mechanisms involved in cell division and chromosome inheritance, intercellular signaling and intracellular transport (via the primary cilium), actin-myelin architecture of neural circuits, genomic stability, organization of cell-cell junctions, cell invasion and migration in cancer, as well calcineurin phosphatase signaling, in both normal and diseased states. These research areas are highly relevant to many aspects of human health.

PI_NAMEs: MULHOLLAND, JONATHAN W (contact)

PROJECT_TERMS: 11 year old;3-Dimensional;Area;Biological Process;biological research;Biomedical Research;Calcineurin;Cell Physiology;cell transformation;Cells;Chromosome Segregation;Cilia;Congenital Abnormality;design;Development;Disease;Extracellular Matrix;fluorescence imaging;frontier;Funding;Genetic Recombination;Genome Stability;Glass;Health;Human;Image;imaging capabilities;imaging facilities;imaging modality;imaging system;Imaging technology;Immunity;instrument;Intercellular Junctions;Invaded;Lateral;light microscopy;Lighting;Maintenance;Malignant Neoplasms;Meiosis;Microscope;Microscopy;migration;Molecular;Myelin;Neurodegenerative Disorders;Neurons;Obesity;organizational structure;Regulation;Request for Proposals;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resource Sharing;Role;Science;Scientist;Signal Pathway;Signal Transduction;Speed;Structure;superresolution imaging;Tissues;ultra high resolution;United States National Institutes of Health;Universities;vesicle transport;Visualization

PROJECT_TITLE: Super-resolution, structured illuminationmicroscope (SIM) for biomedical research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

PHR: Project Narrative: Sulfolobus Spindle-shaped Virus 1 is an astonishingly stable virus, but we do not know how it or many other viruses are made to be stable. This research will use mutagenesis and artificial evolution to determine how virus proteins fit together to make stable virus particles. These results should allow the creation of highly stable nanoparticles and stabilized vaccines and may provide insights into how to destabilize pathogenic viruses, while strengthening the Portland State University research environment.

PI_NAMEs: STEDMAN, KENNETH MARK (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Acids;Amino Acid Substitution;Amino Acids;Archaeal Viruses;Biochemical;Biology;Biomedical Research;Capsid;Capsid Proteins;cold temperature;Collaborations;Cryoelectron Microscopy;design;electron density;Environment;Equipment;Evolution;experience;experimental study;Genetic;genetic selection;glycosylation;Growth;High temperature of physical object;High-Throughput Nucleotide Sequencing;Human Resources;In Vitro;in vivo;Infrastructure;innovation;insertion/deletion mutation;insight;Libraries;Life;Macromolecular Complexes;Methods;Minor;Minority;Modeling;Molecular;Molecular Probes;Mutagenesis;mutant;Mutation;nanoparticle;Native Americans;novel;novel virus;Nucleic Acids;Outcome;Pacific Islander;pathogenic virus;Point Mutation;predictive modeling;protein complex;Proteins;Research;Research Personnel;Research Technics;Resistance;Resolution;Scholars Program;Shapes;Side;Site;Site-Directed Mutagenesis;Standardization;STEM research;structural determinants;Structural Models;Structure;Students;Sulfolobus Spindle-shaped Viruses;Techniques;Temperature;tool;Training;undergraduate research;undergraduate student;Underrepresented Students;Universities;university student;Vaccines;Viral Proteins;Virion;Virus;Viviparous-1 protein;Work

PROJECT_TITLE: Determining the molecular basis for extreme virus stability, a structure-guided approach


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Reactivation from herpesvirus latency is an understudied area with a significant impact on multiple human diseases, and emerging evidence suggests that herpesvirus latency may protect from secondary infections. I will test the hypothesis that gammaherpesvirus latency impacts host protection during prevalent pulmonary infections in a cell intrinsic manner and define relevant mechanisms; furthermore, I will delineate the impact of the microbiota on establishment and maintenance of herpesvirus latency, given the critical impact of the microbiota on immune responses and the broad use of potent antibiotics in medical practice. At the completion of this project, I expect to define the role of latency and reactivation on human immune responsiveness and develop a framework to define how the balance between the microbiota, antibiotic use, and secondary infections are influenced by latent viral infection.

PI_NAMEs: STEED, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: acute infection;Adult;Antibiotics;Area;Bacterial Pneumonia;care providers;Cell Physiology;cell type;Cells;Chronic;Clinical;clinically relevant;Colitis;Collaborations;Critical Care;Critical Illness;cytokine;defined contribution;dysbiosis;Equilibrium;evidence base;experience;Face;Funding Mechanisms;gammaherpesvirus;Gene Expression Profile;Genus Mycobacterium;Health;Herpesviridae;Herpesviridae Infections;Human;human disease;Human Herpesvirus 4;Human Herpesvirus 8;human pathogen;Immune;Immune response;Immune system;Immunity;Immunology;Individual;Infection;influenza infection;Intensive Care;Interferon Type I;Investigation;Knowledge;Label;latent gene expression;Latent virus infection phase;Life;Listeria;Lung;Lung infections;Maintenance;Malignant Neoplasms;Medical;Medicine;microbial;Microbiology;microbiota;Mus;novel;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathway interactions;Patients;Physicians;Play;Pneumonia;Positioning Attribute;Postdoctoral Fellow;Process;programs;Pulmonary Inflammation;reactivation from latency;Regulation;Research;Research Personnel;Respiratory Failure;Respiratory Tract Infections;Role;secondary infection;Shapes;Signal Transduction;Technology;Testing;Time;tissue repair;tool;treatment optimization;Ulcer;Viral;virology;Virus;Virus Diseases;Virus Latency;Wild Type Mouse

PROJECT_TITLE: Intersection of Severe Respiratory Infection and Viral Latency

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE There has been 27.6% increase in cases of depression during the COVID-19 pandemic, particularly among specific vulnerable groups. The study will collect longitudinal data from a large and diverse population of people already enrolled in the EMBARC research study and will use a variety of methods to assess SARS- CoV-2 infection and the social determinant of health (SDOH) impact on neuroinflammation that is associated with depression. The findings of this study have important implications for public health policy and practice.

PI_NAMEs: KIM, LINDA Y. (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 2019-nCoV;Acute;Adaptive Immune System;adaptive immunity;Adult;Anti-Inflammatory Agents;Anti-viral Agents;Autonomic nervous system;Biological Markers;Biological Specimen Banks;Black Populations;Black, Indigenous, People of Color;Blood specimen;Body mass index;Brain-Derived Neurotrophic Factor;burden of illness;C-reactive protein;California;Cardiovascular Diseases;Cardiovascular system;Censuses;Characteristics;Chronic;Chronic stress;Clinical;cohort;Collection;Communities;Corticotropin;COVID-19 pandemic;COVID-19 sequelae;Data;Data Set;Defense Mechanisms;depressive symptoms;Development;Diabetes Mellitus;Discrimination;Disease;Education;Eicosanoid Modulation;Eicosanoids;Enrollment;Environment;ethnic minority;Follow-Up Studies;Generalized Anxiety Disorder;Health;health care availability;health equity;Health Personnel;Health Policy;health practice;Health Services;Housing;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immune;Incidence;indexing;Individual;Infection;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Integrative Medicine;Interleukin-1 beta;Interleukin-10;Interleukin-6;Lead;Leukotrienes;Lipids;Lipoxins;Major Depressive Disorder;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medical;member;Mental Depression;Mental Health;Metabolic;metabolomics;Methods;minority communities;Modeling;Monoclonal Antibodies;multidisciplinary;Natural Immunity;Neighborhoods;Neuroimmune;neuroinflammation;novel;Outcome;Pain;pandemic disease;Participant;Pathway interactions;Patients;Personal Satisfaction;Persons;Population Heterogeneity;post SARS-CoV-2 infection;Prostaglandins;psychological distress;Public Health;Questionnaires;Random Allocation;Recovery;Reporting;Research Personnel;research study;Risk;Role;Sampling;SARS-CoV-2 infection;serosurveillance;Severe Acute Respiratory Syndrome;Social Environment;social health determinants;Specialist;stem;Stress;stressor;Sum;Surveys;Symptoms;Testing;Thromboxanes;Time;TNF gene;Transportation;Vaccines;Variant;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: SARS-CoV-2 and Social Determinants of Health Impact on Inflammation Associated Depression Risk (SSIDR)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative Cognitive decline after radiation therapy is a major complication and has been tied to multifactorial mechanism which includes loss of synapses, white matter damage, endothelial cell damage, and activation of neuroinflammatory markers within the hippocampus and pre-frontal cortex. With increase in long term survival of patients with central nervous system malignancies, there is a critical need to understand the mechanisms behind radiation induced brain injury so that therapies can be targeted to prevent post-radiation cognitive decline. Completion of this project will characterize a non-invasive biomarker of radiation induced cognitive decline that can be translated into clinical practice that can be used for monitoring of synaptic density changes and personalize treatment.

PI_NAMEs: ABOIAN, MARIAM  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;Adult;Anatomy;Axon;axon injury;Behavioral;Biological Markers;Brain;Brain Injuries;Brain Neoplasms;Brain region;cell injury;Central Nervous System;chemotherapy;Child;clinical practice;clinical translation;Clinical Trials;Cognition;cognitive change;Cognitive deficits;cognitive function;cognitive testing;Complication;Contralateral;Cranial Irradiation;density;Development;early detection biomarkers;Early Diagnosis;Early Intervention;Endothelial Cells;Epilepsy;Evaluation;Future;Glioblastoma;Goals;gray matter;Hippocampus;Human;Image;imaging biomarker;Immunohistochemistry;Impaired cognition;Implant;In Vitro;insight;Label;Life;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Measures;Medical;Methods;Modeling;Molecular;Monitor;Nervous System Trauma;neurocognitive test;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;neurosurgery;novel;Oligodendroglia;Operative Surgical Procedures;Pathologic;Patients;personalized medicine;Pharmaceutical Preparations;Positron-Emission Tomography;predictive marker;Prefrontal Cortex;preservation;presynaptic;prevent;Process;protein biomarkers;Proteins;Radiation;Radiation induced damage;Radiation Oncology;Radiation therapy;Radiochemistry;Rattus;response;Rodent;Scanning;serial imaging;Side;standard of care;Synapses;Synaptic Vesicles;Time;timeline;tool;Tracer;Translating;Treatment Protocols;Treatment Side Effects;tumor;Western Blotting;white matter;white matter change;white matter damage

PROJECT_TITLE: PET Biomarker for synaptic density changes after radiation therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PHR: Project Narrative The project is focused on the development of a new collagen-like synthetic polymer as a potential replacement of animal-derived collagen for biomedical applications such as tissue and organ engineering, drug delivery, and wound healing. The synthetic collagen-like polymer would help to eliminate the safety and contamination concerns of animal-derived collagen. In addition, the proposed synthetic route may open the door to synthesis of other polymeric biomaterials based on short repeatable peptide sequences like ELP or RGD peptides.

PI_NAMEs: SLOWINSKA, KATARZYNA  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Amides;Amines;Amino Acid Sequence;Amino Acids;animal tissue;Animals;Artificial Organs;Biocompatible Materials;Biological;Biomanufacturing;biomaterial compatibility;Biomedical Research;career;Cattle;Cell Culture Techniques;Chemicals;Chlorides;Circular Dichroism Spectroscopy;clinical translation;Collagen;Communication;Communities;copolymer;Coupling;crosslink;Data Analyses;Dermal;design;Development;Dipeptides;Drug Delivery Systems;Elastin;endozepine-like peptide ELP;Engineering;Equipment;Exclusion;experimental analysis;experimental study;Family suidae;Fibroblasts;Fostering;frontier;Future;graduate student;hands on instruction;Human;Hydroxyproline;improved;innovation;Kinetics;Laboratories;Lead;mechanical properties;Mechanics;Mentors;Mentorship;Methods;Mission;Modification;Molecular Conformation;Molecular Weight;monomer;novel strategies;Organ;Peptide Synthesis;Peptides;Performance;Phase;polymerization;Polymers;polypeptide;Population;Positioning Attribute;Preparation;prevent;Property;protein aminoacid sequence;Reaction;Reagent;Reconstructive Surgical Procedures;Reporting;Research;Route;Safety;Science;self assembly;Site;Solid;Source;Structure;student participation;Students;Synthesis Chemistry;Time;Tissue Engineering;tissue repair;Tissues;Training;triple helix;undergraduate student;unnatural amino acids;Variant;wound healing

PROJECT_TITLE: De Novo Synthesis of Collagen-Like Polymers for Biomedical Applications


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The ability to accurately and efficiently discriminate others’ gaze direction is critical to social development and real-world functioning, and is disrupted in many psychiatric conditions. The goals of this study are to investi- gate how widespread the problem of altered gaze perception is among psychiatric patients with difficulties in social functioning, understand how this problem contributes to different psychiatric symptoms, and discover the cognitive and brain mechanisms underlying this problem. The results of this study are expected to guide the development of treatment strategies that aim to improve social functioning and quality of life for individuals ex- periencing socially debilitating psychiatric conditions regardless of diagnosis.

PI_NAMEs: TSO, IVY FEI (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Adolescent and Young Adult;Age;Area;autism spectrum disorder;Bayesian Modeling;Behavioral;Behavioral Sciences;biobehavior;Bipolar Disorder;Brain;Categories;Clinical;Cognition;Cognitive;cognitive process;cognitive training;Combined Modality Therapy;Communities;Complex;connectome;Diagnosis;Diagnostic;Dimensions;disability;Discrimination;Disease;effective therapy;emotion regulation;Emotions;Employment;Exhibits;experience;Eye;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;Future;gaze;Goals;Human;Impairment;improved;improved outcome;Independent Living;indexing;Individual;Intervention;Investigation;Literature;Maps;Mental disorders;Monkeys;multimodality;National Institute of Mental Health;neural;neural circuit;neural correlate;Neurobiology;Neurosciences;Participant;Patient Recruitments;Patients;Perception;Perceptual disturbance;personalized medicine;Pharmaceutical Preparations;Phenotype;potential biomarker;Primates;Productivity;Psychiatric Diagnosis;psychiatric symptom;Psychophysics;Psychoses;psychosocial;Quality of life;recruit;Reporting;Research;Research Domain Criteria;Sampling;Scanning;Schizophrenia;Sensory;social;social anxiety;social cognition;social communication;social deficits;Social Development;Social Functioning;Social Phobia;Testing;theory of mind;therapy development;Time;trait;treatment strategy;Vision;Visual;Visual Cortex;Visual System

PROJECT_TITLE: Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigation

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: The Kritzer lab addresses foundational problems in drug discovery. In this MIRA project, we describe new innovations including novel compounds that block key proteins implicated in late-stage cancers, novel classes of compounds that can degrade any cellular protein on demand, and novel methods to understand how large- molecule therapeutics enter cells and how to design them to enter cells more efficiently.

PI_NAMEs: KRITZER, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Adopted;Algorithm Design;Area;Autophagocytosis;Binding;Biological Assay;cell type;Cells;Cellular biology;chemotherapy;Chimera organism;CRISPR screen;Cytosol;Data;Degradation Pathway;design;Disease;DNA Damage;drug development;drug discovery;Endosomes;Genetic;Human;inhibition of autophagy;inhibitor;innovation;Kinetics;Learning;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Molecular Evolution;novel;Penetration;Protac;protein degradation;Protein Family;protein protein interaction;Proteins;research and development;screening;Series;small molecule inhibitor;stapled peptide;Structure;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Diversity Supplement for Imani McDonald - Developing Autophagy-Targeting Chimeras and Optimizing Cell Penetration of Large-Molecule Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: Project Narrative The U-RISE program at North Carolina Agricultural and Technical State University (NC A&T) will substantially increase the number of graduates pursuing advanced degrees in the biomedical sciences and diversify the STEM workforce. To cultivate the science identity of underrepresented students, the program will employ a persistence framework that combines an academic support system, early research experiences and mentoring, collaborative learning, and appreciative advising. The implementation of the goals and objectives of the NC A&T U-RISE program will produce a community of Ph.D. biomedical scientists who will address biomedical issues through the creation of new and innovative technologies and cutting-edge research.

PI_NAMEs: RORIE, CHECO JAMES (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic skills;Academic Training;Agriculture;Biomedical Research;career;Collaborations;college;Communication;community building;Doctor of Philosophy;doctoral student;Educational Curriculum;Educational workshop;Enrollment;Ensure;Event;expectation;Foundations;Funding;Goals;Growth;improved;Mentors;North Carolina;Participant;programs;Research;Research Activity;Research Project Grants;Research Training;Science;scientific literacy;Scientist;Series;skills;skills training;Students;success;Talents;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: NCA&TSU Undergraduate Research Training Initiative for Student Enhancement (U-RISE)

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE  The major goal of this application is to define the function of Histone 3 Lysine 9 tri-methylation (H3K9me3) deposition at the provirus 3’-end during latency reactivation. Two possible models of viral gene expression regulation and host-mediated DNA damage sensing and repair will be simultaneously interrogated. Identifying the methyl transferases involved and defining the function of H3K9me3 will provide fundamental knowledge and an opportunity to sensitize cells to latency reversal therapy.

PI_NAMEs: D'ORSO, IVAN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: antiretroviral therapy;Applications Grants;Biology;CD4 Positive T Lymphocytes;Cell model;Cells;chemical genetics;chromatin immunoprecipitation;Clinical;Clonal Expansion;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Deposition;Detection;Development;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Enzymes;Epidemic;Epigenetic Process;Event;extend lifespan;Future;Gene Expression;gene repression;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Genome;Genomic Segment;Goals;Growth;Highly Active Antiretroviral Therapy;Histone H3;histone methylation;histone modification;Histones;HIV-1;Human;Immune;Immune signaling;Immune system;Immunologic Surveillance;Knock-out;Knowledge;Link;Lysine;Maintenance;Mediating;Methylation;Mission;Modeling;National Institute of Allergy and Infectious Disease;novel;Pathway interactions;Phase;Phenotype;Precision therapeutics;Process;Proliferating;Proviruses;reactivation from latency;Refractory;repaired;Reporting;Research;Resolution;response;Role;Series;Signal Induction;Signal Transduction;Surveys;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Transferase;tumor-immune system interactions;Viral;Viral Gene Expression Regulation;Virus Latency

PROJECT_TITLE: Defining the epigenetic landscape at the HIV-1 provirus 3’-end

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Sepsis

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

PHR: We will develop Sepsis Pulse, a suite of innovative tensor-based machine learning tools for the analysis of elec- tronic health record (EHR) data, with the goal of improving progress assessment, patient phenotyping, and treat- ment planning of sepsis. These machine learning tools will focus on aligning sepsis progress timelines, pheno- typing, and estimating treatment effects while accounting for the high dimensionality, sparsity, and temporality of EHR data. Sepsis Pulse will be integrated as a module within Sepsis Watch, the digital workflow utilized in Duke Hospital’s healthcare system, to enhance the quality and outcomes of patient care.

PI_NAMEs: ZHANG, ANRU  (contact)

PROJECT_TERMS: Address;Admission activity;Adult;Algorithms;Awareness;care seeking;Caring;Characteristics;Classification;Clinic;Clinical;clinical decision-making;clinical subtypes;Collaborations;Complex;Critical Care;Data;Data Collection;Detection;Diagnosis;digital;dimension reduction;Disease;Early Diagnosis;Economic Burden;electronic health information;Electronic Health Record;electronic structure;Ensure;Event;Exhibits;Functional disorder;Goals;Health;Healthcare Systems;Hepatic;high dimensionality;Hospital Mortality;Hospitals;Hour;Immune response;improved;Incubated;Individual;innovation;insight;Intervention;Kidney;Lung;Machine Learning;machine learning method;Mechanical ventilation;Medical;Medicine;Methods;Modeling;Monitor;Names;novel;Organ;Outcome;Patient Admission;Patient Care;Patient-Focused Outcomes;Patients;personalized medicine;personalized predictions;Phase;Phenotype;Physiologic pulse;Procedures;Prognosis;Registries;relational database;Research;Sample Size;Selection for Treatments;Sepsis;septic patients;Severities;statistical and machine learning;Structural Models;Structure;Technology;Time;timeline;tool;treatment effect;treatment optimization;Treatment outcome;treatment planning;treatment strategy;United States;Variant;Vasoconstrictor Agents;Vulnerable Populations;Work

PROJECT_TITLE: Integrated Detection and Classification of Sepsis via Tensor Methods Using EHR

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Development of brown-like white adipose tissue, beige fat, helps to reduce obesity and Type 2 diabetes, as the recently identified fat can burn energy to generate heat. We will investigate the role that a protein, TRB3, and a dietary supplement, Leucine, may play in regulation of beige fat emergence and activity. Better understanding beige fat formation and the dietary supplements that affect it may lead to the development of new drugs to treat obesity and its complications.

PI_NAMEs: KOH, HO-JIN  (contact)

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Adopted;Adrenergic Agonists;Adult;Affect;African;AKT inhibition;American;Anti-diabetic Drugs;Area;Attention;Body fat;Branched-Chain Amino Acids;Brown Fat;Cancer Cachexia;Cardiovascular Diseases;Characteristics;Chronic;Clinical Treatment;Data;Denervation;Development;Diabetes Mellitus;diabetic;diet-induced obesity;dietary;dietary supplements;Disease;Drosophila genus;effective therapy;endoplasmic reticulum stress;Energy Intake;Energy Metabolism;exercise training;expectation;Fatty acid glycerol esters;Glucose Intolerance;glucose metabolism;Goals;Health;High Fat Diet;Homologous Gene;Human;Impairment;improved;Incidence;Ingestion;innovation;insight;Insulin Resistance;insulin signaling;Kidney;Knock-out;Knockout Mice;Leucine;lipid metabolism;Liver;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mus;muscle form;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Obese Mice;Obesity;obesity prevention;obesity treatment;overexpression;Overweight;Persons;Pharmaceutical Preparations;Play;Prevalence;prevent;Prevention;Proteins;Regulation;Research;Research Personnel;response;Risk;Role;Signal Transduction;Signaling Molecule;Sleep Apnea Syndromes;Stimulus;subcutaneous;Techniques;Testing;therapy development;Thermogenesis;Thinness;Tissue Differentiation;Tissues;Training;Transplantation;treatment strategy;Triglycerides;Underrepresented Students;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Effect of TRB3 and Leucine Supplement on Beige Fat Formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: SAN JOSE

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: Project Narrative Neurophysiological and psychiatric disorders lead to severe cognitive impairments in patients and have been attributed to pathological neural synchronization and abnormal oscillations in brain circuits associated with specific diseases. The proposed computational study will facilitate the development of novel therapeutically effective closed-loop deep-brain stimulation technologies for Parkinson’s disease and other neurophysiological disorders caused by abnormal synchronous firing rhythms of neurons.

PI_NAMEs: KUMAR, GAUTAM  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Animal Model;Animals;Automation;Biological;Biological Markers;Biomedical Research;Biophysics;Brain;Brain Diseases;Brain region;Clinical;computational neuroscience;computer framework;computer studies;cost;Coupling;Data;data-driven model;Deep Brain Stimulation;design;Development;Devices;Dimensions;Disease;Electrophysiology (science);Epilepsy;experience;Feedback;follow-up;Frequencies;Ganglia;Goals;Grant;hippocampal pyramidal neuron;Hippocampus;Impaired cognition;in silico;In Vitro;in vivo;Intervention;Investigation;Knowledge;Lead;Machine Learning;Major Depressive Disorder;Manuals;Measures;Mental disorders;Methods;Modeling;multiple input multiple output;network models;neural;neural stimulation;neuronal patterning;Neuronal Plasticity;Neurons;neurophysiology;neuroregulation;novel;novel therapeutics;open source;optimal control theory;optogenetics;Output;overtreatment;Parkinson Disease;Pathologic;Patients;pharmacologic;Phase;physiologic model;Physiological;Positioning Attribute;predictive modeling;Productivity;Property;Protocols documentation;Psyche structure;Publishing;Pythons;Research;Research Personnel;Rodent Model;Role;Schizophrenia;Severities;Signal Transduction;software development;Software Tools;Stimulus;Symptoms;System;Techniques;Technology;Testing;Therapeutic;therapeutically effective;Time;tool;treatment duration;Tremor;underrepresented minority student

PROJECT_TITLE: Closed-Loop Deep Brain Stimulation for Controlling Abnormal Neural Synchronization and Oscillations

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Women's Health Research

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: Project Narrative In this study, we propose to investigate the biogenesis of mirtrons in cancers and to examine the potential roles of mirtrons in the modulation of tumor immune responses. Mirtron is an emerging new RNA subclass in the field but its biological importance in humans is completely not understood. Thus, successful completion of the project will advance current knowledge of mirtrons and their involvement in the immune regulation that will inform therapeutic strategies to treat cancers.

PI_NAMEs: CHEN, KUAN-HUI  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;Adopted;Alkaline Phosphatase;Antigen Presentation;Binding;Binding Sites;Biogenesis;Biological;Breast Cancer Cell;Breast Cancer cell line;Bypass;cancer cell;cancer subtypes;cancer therapy;Cell Line;Cells;Chemistry;CRISPR/Cas technology;cytokine;Data;Development;Digestion;Disease;Disease Progression;DNA-Directed RNA Polymerase;Ectopic Expression;Endocytosis;Endosomes;Ensure;Enzymes;Event;Exhibits;Exoribonucleases;exosome;experimental study;Exposure to;fighting;Flow Cytometry;G-Quartets;gene regulatory network;Generations;Guanine;Guanine Nucleotides;Guanosine;Human;human disease;Immune;immune function;Immune response;Immune System Diseases;Immunity;immunoregulation;inhibitor;Interruption;knock-down;Knock-out;Knowledge;Lead;Libraries;Ligand Binding;Ligands;Link;Literature;Lower Organism;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammals;Mediating;Methodology;MicroRNAs;Modification;Monitor;NF-kappa B;Normal Cell;novel;novel therapeutics;nuclease;Nucleotides;Poly A;Polymerase;prevent;Process;Production;Property;Proteins;Reaction;Regulation;Reporter;Research;Resistance;Ribonucleases;RNA;RNA Splicing;RNA Viruses;Role;selective expression;Signal Transduction;Site;Small RNA;Sorting;Spectrum Analysis;Structure;Tail;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;TLR1 gene;TLR7 gene;tumor;tumor progression;Tumor Promotion;vector;Work

PROJECT_TITLE: Dissecting the role of mirtrons in human cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: NORTHRIDGE

ORG_DEPT: PHYSICS

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative Cardiac arrhythmias are responsible for the death of over 250,000 people per year in the United States alone. However, the underlying mechanisms for arrythmias is still not fully understood. The goal of this project is to understand how a single mutation in a protein that regulates calcium in the heart, can cause a heritable arrhythmia syndrome called Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). Our approach is to combine a multi-scale computational approach to model molecular, cellular, and tissue dynamics in the heart.

PI_NAMEs: SHIFERAW, YOHANNES  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Affect;Affinity;Amino Acids;Architecture;Arrhythmia;Behavior;Binding;Binding Sites;Biophysics;Calcium;Calcium Oscillations;Calcium Signaling;Calmodulin;Cardiac;cardiac pacing;Catecholaminergic Polymorphic Ventricular Tachycardia;Cell model;Cells;Cessation of life;Complex;computer framework;Computer Models;computerized tools;Computing Methodologies;Coupled;Coupling;Dangerousness;Data;Development;distributed model;Electrophysiology (science);Exercise;Free Energy;Future;Genetic study;Goals;Heart;Hereditary Disease;Heritability;Homeostasis;Individual;Induced Mutation;Inherited;innovation;insight;Kinetics;Link;Modeling;Molecular;molecular domain;molecular dynamics;molecular mechanics;molecular modeling;molecular scale;multi-scale modeling;Muscle Cells;mutant;Mutation;Myocardium;Organ;Patients;Persons;pharmacologic;phenomenological models;Phenotype;Point Mutation;Population Dynamics;prevent;Probability;Property;Proteins;Purkinje Cells;Reaction;Research;Research Personnel;Resolution;response;Ryanodine Receptor Calcium Release Channel;Signaling Protein;simulation;Site;Stress;Structure;Structure of purkinje fibers;Sudden Death;Syndrome;System;Testing;three-dimensional modeling;Tissue Model;Tissues;tool;United States;voltage

PROJECT_TITLE: Multi-scale computational modeling of calmodulin mutations associated with CPVT


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Recent advances in single particle cryo-EM have transformed structural biology. Here, we request funds to bring a critical resource, a Glacios 2 cryo-TEM with a Falcon 4i direct electron detector, as a shared core resource at Mount Sinai. The microscope will greatly enhance the NIH-funded research of users throughout the Institution and contribute directly to Mount Sinai’s mission to foster innovation and support investigation into the biological underpinnings of human disease.

PI_NAMEs: AGGARWAL, ANEEL K. (contact)

PROJECT_TERMS: Agreement;atomic transition;Biological;biological systems;Contract Services;cost;Cryoelectron Microscopy;cryogenics;Data;Data Collection;Detection;Devices;Disease;Electrons;Funding;Generations;Goals;Grant;Home;human disease;Infrastructure;Institution;Measures;medical schools;Microscope;Optics;particle;payment;Preparation;Research Personnel;Research Project Grants;Resolution;Sampling;Site;structural biology;Structure;success;Titan;United States National Institutes of Health;Wages

PROJECT_TITLE: Glacios 2 Cryo-TEM for Structure Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]