ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  Many smokers have taken up e-cigarettes hoping to quit smoking and reduce their health risks, but more than half of e-cigarette users continue to use cigarettes. Current research suggests these dual users of cigarettes and e-cigarettes are at high risk of negative health outcomes. This project designs and tests campaign messages and ads to educate dual users of cigarettes and e-cigarettes about their health risks and encourage them to quit cigarettes and e-cigarettes.

PI_NAMEs: BYRON, MICHAEL JUSTIN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: addiction;Adult;Advocate;Affect;arm;Attention;Automobile Driving;Back;Behavior;Behavioral;Belief;Cardiovascular system;career;Cause of Death;Cigarette;Cigarette Smoker;cigarette smoking;cigarette user;combustible cigarette;combustible tobacco;Communication;design;Development;Disease;e-cigarette cessation;Effectiveness;effectiveness testing;Electronic cigarette;electronic cigarette user;experimental study;Exposure to;Focus Groups;Goals;Grant;hands-on learning;Health;Health Benefit;health communication;high risk;Intention;Knowledge;Literature;Malignant Neoplasms;Measures;Methodology;Motivation;Nicotine;Outcome;Patient Self-Report;Persuasive Communication;pilot test;prevent;Process Measure;Psychology;Randomized;Research;response;Risk;sample fixation;Science;Scientist;skills;Smoke;Smoker;Smoking;smoking cessation;social;Surveys;Technology;Testing;Text Messaging;theories;Time;Tobacco;tobacco control;tobacco products;tobacco regulation;Tobacco use;Toxin;Training;vaping;Visual;visual tracking

PROJECT_TITLE: Designing and evaluating communication for dual users of e-cigarettes and combustible cigarettes


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: COON, JOSHUA J (contact)

PROJECT_TITLE: National Center for Quantitative Biology of Complex Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: BOOCKVAR, KENNETH S. (contact)

PROJECT_TERMS: Adverse drug effect;Adverse drug event;Affect;Aging;Alzheimer's disease related dementia;Anti-Cholinergics;Antipsychotic Agents;Attitude;Caregivers;Caring;Chronic Disease;Clinical;Cognition;Cognitive;Communication difficulty;Communities;community setting;comorbidity;Data;Data Element;Data Sources;Dementia;dementia risk;Diabetes Mellitus;Disease Management;end of life;Face;fall risk;Frequencies;Functional impairment;Goals;Health;Health and Retirement Study;health data;Hospitalization;Impaired cognition;Impairment;improved;interest;Intervention;Knowledge;Life Expectancy;Link;Medical;Medicare;Medicare Part A;Nursing Homes;older adult;Older Population;Outcome;Patients;Pattern;Persons;Pharmaceutical Preparations;Play;Population;population based;Predisposition;preference;Preventive therapy;Quality of life;Reporting;Research;Risk Factors;Role;Series;socioeconomics;Surveys;Symptoms;trend;Vulnerable Populations;willingness

PROJECT_TITLE: Unnecessary and Harmful Medication Use in Older Adults with Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: ORNSTEIN, KATHERINE A (contact)

PROJECT_TERMS: access disparities;Accounting;Address;adverse outcome;Aging;Behavior;burden of illness;care coordination;care delivery;care preference;Caregivers;caregiving;Caring;Characteristics;clinical care;Clinical Services;Cognitive;Communities;comorbidity;Complex;cost;Cost Savings;Data;Dementia;density;Disparity;Evolution;experience;Family;Family Caregiver;family caregiving;Fostering;Future;Gender;Geographic Locations;Growth;Health;Health and Retirement Study;health care availability;health care service utilization;Health Policy;Health Services Accessibility;Home;Home Care Services;Homebound Persons;Hospitalization;improved;improved outcome;Individual;individual variation;insight;institutional care facility;Institutionalization;Investigation;Knowledge;Link;Long-Term Care;Longitudinal cohort;Medical;Medicare;Medicare claim;mental function;Methods;Neighborhoods;Nurse Practitioners;Nurses;Outcome;Patient-Focused Outcomes;Patients;person centered;Persons;Physical Function;physical therapist;Physician Assistants;Physicians;Population;population based;Prevalence;Qualifying;Quality of Care;rapid growth;Research;Resources;Safety;Self Care;Services;skills;social;social determinants;social factors;Social Work;socioeconomics;Technology;traditional care;Travel;trend;Unmarried;urban area;Vulnerable Populations;Work

PROJECT_TITLE: Home-Based Clinical Care for Persons with Dementia


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Narrative Genome wide association studies (GWAS) are the dominant study design for identifying genetic variants associated with complex human disease. However, identifying the molecular and cellular effects responsible for a GWAS association is challenging and slow, which has thus far blunted the impact of GWAS on the understanding and treatment of human disease. This project will develop a new genomic community resource – the “Association to Function Knowledge Portal” – in order to make data and methods for interpreting GWAS associations more easily accessible, thus accelerating the pace at which findings from GWAS can be used to improve human health.

PI_NAMEs: BURTT, NOEL P;FLANNICK, JASON  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Address;Area;Bioinformatics;Biological;Biological Assay;Calibration;Catalogs;causal variant;Cells;Clinical;Collaborations;Communities;Complex;Computer software;Data;data access;Data Aggregation;Data Commons;data integration;data resource;Data Set;data sharing;data visualization;Dedications;design;Disease;disorder risk;Elements;epigenomics;functional genomics;Funding;Genes;Genetic;genetic association;genetic variant;genome resource;genome wide association study;genomic data;Genomics;Goals;graph database;Health;Human;human disease;improved;innovation;insight;Knowledge;knowledge graph;Knowledge Portal;Manuals;Maps;Methods;Molecular;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Output;Pathway interactions;Phenotype;precision medicine;Research;Research Design;Research Personnel;Resources;Source;Specific qualifier value;statistics;Tissues;trait;transcriptomics;Translating;Trust;Variant;Visual;web based interface;web portal;Work

PROJECT_TITLE: The Association to Function Knowledge Portal: a genomic data resource for translating GWAS associations to biological effects


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Services;Pain Research;Palliative Care

PI_NAMEs: ALDRIDGE, MELISSA DIANE (contact)

PROJECT_TERMS: Address;Admission activity;Advanced Malignant Neoplasm;Aging;Behavior;care preference;Caregiver support;Caring;Cessation of life;cohort;Communication difficulty;Communities;Community Healthcare;Data;Data Set;Dementia;dementia care;Diagnosis;Elements;Eligibility Determination;end of life;end of life care;Enrollment;Ensure;Enteral Feeding;experience;Family;Family member;Goals;Health;Health and Retirement Study;health care service utilization;health care settings;Healthcare Systems;Home;Hospice Care;hospice environment;hospice utilization;Hospitalization;Hospitals;improved;improved outcome;Individual;Intravenous;Knowledge;Life;Life Expectancy;Life Experience;Location;Longitudinal Studies;Malignant Neoplasms;Medical;Medicare;meetings;Modeling;Nursing Homes;older adult;Outcome;Pain;Pain management;Parenteral Nutrition;patient home care;Patients;Pattern;payment;Persons;Physical Restraint;Policies;Population;population based;Population Study;preference;pressure;Prevalence;Primary Care;Prognosis;psychosocial;Quality of Care;Reporting;Research;Sampling;socioeconomics;Spirituality;Surveys;Symptom Burden;symptom management;Time;trend;Work

PROJECT_TITLE: Hospice Care for Community-Dwelling Persons with Dementia


PROJECT_TERMS: Address;Analytical Chemistry;base;Biology;Biomedical Research;Biomedical Technology;Cells;Collaborations;Communication;community engagement;Complex;Computer software;Disclosure;Ensure;Funding;Generations;Goals;Grant;Institution;Intellectual Property;interest;Internet;Journals;Learning;Legal patent;Manuscripts;Marketing;mass spectrometer;Mass Spectrum Analysis;material transfer agreement;Methods;Mission;Molecular;multiple omics;Nature;new technology;Output;Peer Review;Proteome;Proteomics;Publications;Publishing;Reporting;Research;Research Personnel;Resources;Services;success;System;Technology;technology development;Technology Transfer;Training;Training Programs;translational medicine;United States National Institutes of Health;Writing


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Inequities in access and outcomes of health services are a pervasive problem that has remained essentially unchanged over the past several decades in the United States, particularly in the Southeastern United States. This T32 post-doctoral fellow application proposes to train the next generation of health services researchers to receive multidisciplinary training in methods to both describe and address inequities in access to care, outcomes of care, and healthcare delivery in order to reduce health inequities in health services.

PI_NAMEs: DICKERT, NEAL WORKMAN (contact);PATRICK, STEPHEN W

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Emory Health Services Research Center Training Grant


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Food insecurity is highly prevalent among college students and is associated with poor general and mental health, higher weight status, inadequate physical activity and sleep, and poor diet quality in this emerging adult population. Food insecurity likely influences cardiovascular and metabolic health (CVMH) among college students via several mechanisms, however, this relationship has received little attention. This project will elucidate mechanisms by which chronic food insecurity impacts CVMH among college students—a modifiable target for prevention of poor CVMH that is biologically plausible and common, and therefore potentially high impact.

PI_NAMEs: MARTINEZ, SUZANNA M (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Adolescence;Adult;Affect;Age;American Heart Association;Area;Attention;Behavior;Black race;Blood Glucose;blood lipid;Blood Pressure;Body mass index;California;Cardiometabolic Disease;cardiometabolism;cardiovascular risk factor;Cardiovascular system;Cause of Death;Characteristics;Chronic;cohort;Collaborations;college;critical period;Cross-Sectional Studies;Data;Development;Diet;Disparity;Economics;emerging adult;emerging adulthood;Environment;Exhibits;experience;Family;Food;food insecurity;food security;Future;Generations;Glucose;Health;Health behavior;health disparity;Health Policy;Heart Diseases;high risk;higher education;improved;Infrastructure;Interdisciplinary Study;interest;Intervention;Investigation;Knowledge;Latino;Life;Life Cycle Stages;Low income;Measurement;Measures;Mediating;Mediator;Mental Health;Metabolic;Modeling;modifiable risk;nicotine exposure;Non-traditional Students;Outcome;Pathway interactions;Phase;Physical activity;Policies;Population;Positioning Attribute;pressure;Prevention;Process;Random Allocation;recruit;Research;Risk;Role;Sleep;sleep health;Social support;Stress;Students;System;theories;Time;Underserved Population;Unhealthy Diet;United States National Institutes of Health;Universities;university student;Weight;Work;young adult

PROJECT_TITLE: Food Security and Cardiovascular and Metabolic Health

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Hearing Loss;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: LA MARQUE

ORG_NAME: MICROGEN, LLC

ORG_STATE: TX

PHR: Project Narrative This project aims to develop a rapid, sensitive test to confirm cCMV diagnosis in neonates using dried blood spots (DBSs). Rapid, user-friendly tests to detect cCMV in DBSs are currently not available. By reducing the severity of disease via faster diagnosis, the health and well-being of infected infants will be significantly improved.

PI_NAMEs: STOWE, RAYMOND PRESTON (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Address;Affect;Anti-viral Therapy;Awareness;Biological Assay;Birth;Birthing Centers;Blindness;Blood;Brain;Buffers;Cells;Chemicals;Child;Childhood;Clinic;Clinical;clinical practice;Clinical Sensitivity;Cognitive deficits;commercial application;commercialization readiness;Communicable Diseases;congenital cytomegalovirus;cost;Counseling;Cytolysis;Cytomegalovirus;Cytomegalovirus Infections;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;Disease;DNA;Dryness;Economic Burden;Enzymes;Evaluation;Exhibits;Financial Hardship;Formulation;Goals;Health;Healthcare Systems;hearing impairment;high throughput screening;Hospitals;improved;in-vitro diagnostics;Infant;infant infection;Infrastructure;innovation;Instruction;instrument;isothermal amplification;Laboratories;Labyrinth;Language Development;Manuals;manufacture;Manufacturer;Medical;Methods;Morbidity - disease rate;mortality;Neonatal;neonatal care;neonate;Nerve;Neurological disability;Newborn Infant;non-genetic;novel;Nucleic Acids;Outcome;pathogen;Patients;Performance;performance tests;Personal Satisfaction;Phase;Polymerase;Predictive Value;Preparation;preservation;Procedures;prospective;Public Health Applications Research;Publications;Publishing;rapid diagnosis;Rapid screening;Reagent;Reproducibility;research and development;Saliva;sample collection;Sampling;screening;Sensitivity and Specificity;Sensorineural Hearing Loss;Severities;Severity of illness;Site;Small Business Innovation Research Grant;sound;Specimen;Spottings;standard of care;Standardization;System;technological innovation;Technology;Temperature;Testing;tool;Training;Urine;user-friendly;Vial device;Viral;virtual;waiver

PROJECT_TITLE: Development of a High Throughput Assay for Rapid Screening of Congenital Cytomegalovirus Infection using Dried Blood Spots

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Gene Therapy;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Immune based treatment strategies are increasingly employed to treat patients with Non-Hodgkin Lymphoma (NHL), but many patients still experience relapse. In this study I seek to identify biomarkers that are predictive of relapse following immunotherapy, and also to gain an understanding of the mechanisms underlying these relapses. This project will build a foundation for future clinical trials by informing the development of improved immunotherapies for this illness, thus directly contributing to the NIH mission to seek basic knowledge about the nature of living systems that will help to improve health, reduce illness and disability, and lengthen life.

PI_NAMEs: SWORDER, BRIAN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: adverse outcome;Aftercare;Antigen Targeting;Architecture;B-Cell Lymphomas;B-Lymphocytes;Bioinformatics;biomarker identification;Cancer Personalized Profiling by Deep Sequencing;cancer type;Candidate Disease Gene;career;CD19 gene;cell free DNA;Cell Lineage;Cell Physiology;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;cohort;computerized tools;cytotoxicity;Data;design;Detection;Development;disability;Disease Progression;DNA Sequence Alteration;Doctor of Philosophy;engineered T cells;Exhibits;experience;Foundations;Future;Gene Expression;Gene Expression Profiling;Genes;Genomics;Goals;Health;Immune;Immunohistochemistry;Immunophenotyping;Immunotherapy;improved;In Vitro;in vitro Model;Inferior;Infusion procedures;innovation;Knowledge;Lead;Life;Lymphoma;Lymphoma cell;Measurement;Mediating;medical schools;Mentorship;Methods;Mission;Modeling;Molecular;Monitor;Mutation;Nature;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Organism;Organoids;Outcome;Patient-Focused Outcomes;Patients;PAX5 gene;Phenotype;Plasma;Population;predicting response;Predictive Factor;Primary Neoplasm;prognostic significance;Progressive Disease;protein expression;Recurrence;Refractory;Relapse;relapse prediction;Research Personnel;Resistance;resistance gene;resistance mechanism;resistance mutation;response;Role;Sampling;Surface;System;T cell therapy;T-Lymphocyte;targeted sequencing;targeted treatment;Techniques;therapy development;tissue culture;tool;transcriptome sequencing;Translating;Treatment Failure;treatment response;treatment strategy;tumor;Tumor Biology;tumor DNA;Tumor Escape;tumor immunology;tumor microenvironment;Tumor Tissue;Tumor-Derived;tumor-immune system interactions;United States National Institutes of Health;Universities

PROJECT_TITLE: Determinants of resistance to engineered T-cell therapies targeting CD19 in lymphoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: FLAGSTAFF

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: Project Narrative Infectious Leptospira cause leptospirosis following contact with mucosa through wounds or ingestion, leading to headaches, fever, jaundice, kidney or liver failure, or death in about 1.03 million people each year. These bacteria are found worldwide and are shed in urine into the environment by mammalian hosts, however almost nothing is known about temporal and spatial pathogen population dynamics and the importance of different mammalian host species in cycling and transmission to humans. This information is essential for controlling and avoiding disease.

PI_NAMEs: PEARSON, TALIMA ROSS (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Address;Animal Sources;Animals;Area;Bacteria;Biological;Biological Assay;Case Study;Cessation of life;Clinical;Communities;Complex;Contracts;Death Rate;Disease;Disease Outbreaks;disorder control;disorder prevention;Domestic Animals;Ecology;Ecuador;Environment;Epidemiology;Exclusion;experience;exposed human population;Exposure to;Family;Fever;follow-up;Future;Genetic Variation;genome sequencing;Genotype;Hawaii;Headache;Home;Human;Icterus;Individual;Infection;Infection Control;Infection prevention;Ingestion;insight;Interview;Investigation;Kidney Failure;Knowledge;Leptospira;Leptospirosis;Link;Liver Failure;Livestock;Location;Low income;Methods;Modernization;Molecular;Mucous Membrane;novel;Outcome;pathogen;Pathogenicity;Patients;Pattern;Persons;Play;Population Dynamics;Prevalence;Prevention strategy;recruit;Resolution;Risk;Risk Factors;Role;Rural;rural area;Rural Community;rural environment;Sampling;Seasonal Variations;Seasons;Site;Slum;Soil;Source;Symptoms;Time;tool;transmission process;urban area;urban setting;Urine;Variant;Water;whole genome;wound;Zoonoses

PROJECT_TITLE: Leptospira prevalence, cycling, and infection in the peridomestic environment

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Digestive Diseases;Neurosciences;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Nausea and vomiting (emesis) act as primitive aspects of our physiology and behavior that ensure survival and, contrarily, are also ubiquitously present side effects of drug treatments for chronic disease (e.g., obesity, diabetes, cancer) that reduce medical pharmacotherapy tolerance. Here, we address the antiemetic mechanism and potential of gastric inhibitory polypeptide (GIP) and GIP receptor activation as a novel system contributing to clinical drivers of emesis (e.g., glucagon-like-peptide-1 (GLP-1)-based drugs for obesity and diabetes, chemotherapy in cancer). Via this investigation, the work proposed may positively impact treatment of chronic metabolic diseases by improving the management of nausea and vomiting driven by common drug therapies.

PI_NAMEs: DE JONGHE, BART C (contact);HAYES, MATTHEW R

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Adverse event;Agonist;analog;Anatomy;Animal Model;Animals;antagonist;Anti-emetics;Antiemetic Effect;Attenuated;attenuation;Award;Behavior;Behavioral;behavioral pharmacology;Body Weight decreased;Cachexia;Cell Nucleus;Cells;chemotherapy;Chronic;Chronic Disease;Cisplatin;Clinical;Clinical Trials;clinically relevant;comorbidity;comparative;Complex;Data;debilitating symptom;Diabetes Mellitus;Dorsal;Drug Side Effects;Emetics;Ensure;Exhibits;FDA approved;Feeding behaviors;Ferrets;GABA Receptor;Gastric Inhibitory Polypeptide;gastric inhibitory polypeptide receptor;gastrointestinal;Genetic Transcription;glucagon-like peptide 1;Glucose;glycemic control;Healthcare;Heterogeneity;hindbrain;improved;Intestines;Investigation;Life;Ligands;Malaise;Malignant Neoplasms;Mediating;Medical;Metabolic;Metabolic Diseases;Modernization;Molecular;Mus;Nausea;Nausea and Vomiting;Nausea and Vomiting Therapy;neural;Neuroanatomy;neurogenetics;neuromechanism;Neurons;Neurosecretory Systems;novel;nutrition;Obesity;Outcome;patient prognosis;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Play;Population;pre-clinical;Pre-Clinical Model;prevent;Publications;Publishing;Quality of life;Rattus;Receptor Activation;Receptor Signaling;Reporting;response;Role;Shrews;side effect;Stimulus;Structure of area postrema;Structure of beta Cell of islet;System;TACR1 gene;Testing;Therapeutic;transcriptomics;virtual;Vomiting;Work

PROJECT_TITLE: Neural Mechanisms of Nausea, Vomiting, and Energy Dysregulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(04)M]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Neuroscience is a dynamic and interdisciplinary field that requires equally dynamic and interdisciplinary training to ensure forward progress against the many devastating neurological and mental health diseases that plague mankind. Our trainees receive a contemporary technologically advanced education combined with personal mentoring and career development that assures their future commitment to the neurosciences.

PI_NAMEs: MONG, JESSICA AURORA (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TITLE: Multidisciplinary Training Program in Neuroscience


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Organ Transplantation;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Prior successful interventions to address racial and socioeconomic inequities in access to kidney transplantation have been focused on provider- and patient-level interventions, and yet substantial health system barriers have prevented equity in access to kidney transplantation. The proposed study seeks to adapt and enhance sustainability of proven educational and quality improvement interventions to target multiple health systems– dialysis facilities and transplant centers – as well as clinical staff and patients in the Southeastern United States to target the policies, practices, and structures of these health systems that pose barriers to underrepresented minorities with end-stage kidney failure seeking a kidney transplant. If successful, interventions could be adapted and scaled nationally, where our health system partners are committed to transplant equity.

PI_NAMEs: PASTAN, STEPHEN ;PATZER, RACHEL E (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;access disparities;Address;Administrator;Adopted;Adult;anti-racism;Awareness;black patient;Black race;Caregivers;Clinical;Communities;community based participatory research;Complex;cost;design;Dialysis procedure;disparity reduction;Education;Educational Intervention;Educational Status;effectiveness evaluation;Electronic Mail;End stage renal failure;Equity;Evaluation;Facility Controls;Feedback;Focus Groups;Goals;Health care facility;Health Surveys;Health system;Hybrids;implementation strategy;implementation/effectiveness;improved;Incidence;Inequity;informant;Intervention;intervention mapping;Interview;Kidney Diseases;Kidney Failure;Kidney Transplantation;lens;Logistics;low socioeconomic status;Medical;Methods;Minority;Needs Assessment;North Carolina;Operative Surgical Procedures;Organ;organizational readiness;Outcome;Participant;patient advocacy group;patient level intervention;Patients;Policies;Population;Positioning Attribute;pragmatic intervention;prevent;primary outcome;Process;process evaluation;Provider;provider communication;Quality of life;Quasi-experiment;Race;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Risk;Schedule;social;socioeconomic disparity;Socioeconomic Status;South Carolina;Southeastern United States;Structural Racism;Structure;successful intervention;Surveys;transplant centers;Transplantation;treatment as usual;Underrepresented Minority;usability;Waiting Lists

PROJECT_TITLE: The RaDIANT Health Systems Intervention for Equity in Kidney Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PI: Nguyen, Lien PROJECT NARRATIVE (3 sentences): Alzheimer's disease (AD) currently affects approximately 5.8 million people in the United States, however no effective treatments are available and causes for most sporadic AD cases remain unclear. Studies in this proposal will examine the possible contribution of repeat expansion mutations to late-onset sporadic cases of AD. Understanding if novel repeat expansion mutations contribute to AD will provide novel insight into the molecular mechanisms of AD and accelerate therapeutic development. ! Project Narrative

PI_NAMEs: NGUYEN, LIEN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;abeta deposition;abeta toxicity;Acceleration;Activities of Daily Living;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Antibodies;apolipoprotein E-4;Autophagocytosis;Autopsy;behavioral impairment;Biological Assay;Biology;Brain;Brain region;C-terminal;C9ORF72;CASP8 gene;Clinical;Complex;Data;Dementia;Detection;Disease;disorder risk;DNA Probes;Double-Stranded RNA;Early Onset Familial Alzheimer's Disease;effective therapy;extracellular;follow-up;Frequencies;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;General Population;Genes;Genetic;Genomic DNA;Grant;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;Human Genome;human old age (65+);hyperphosphorylated tau;Impaired cognition;individual patient;Induced pluripotent stem cell derived neurons;Inherited;insight;Late Onset Alzheimer Disease;Link;Methods;Modeling;Molecular;multicatalytic endopeptidase complex;Mus;Mutation;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuromuscular Diseases;neuron loss;novel;novel therapeutics;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Penetrance;Persons;Polymers;Predisposition;presenilin-1;presenilin-2;protein aggregation;Proteins;proteostasis;ran GTP-Binding Protein;rapid technique;Repetitive Sequence;Reporting;Risk Factors;RNA;Role;Sampling;Senile Plaques;Southern Blotting;Stress;synaptic function;tau Proteins;tau-1;Techniques;Testing;Text;Therapeutic;therapeutic development;therapeutic target;Tissues;Toxic effect;Toxicity Tests;Translations;United States;Variant

PROJECT_TITLE: Identifying and understanding the role of repeat RNAs and RAN proteins in Alzheimer's disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Multiple sclerosis (MS) results from an immune-response which triggers inflammation and demyelination in the central nervous system (CNS). There are an estimated 450,000 MS patients in United States alone. Unlike many other neurodegenerative diseases, MS affects mainly young adults; the lifetime direct and indirect costs estimated at $1.2 million per patient. Several sphingosine-1-phosphate receptor 1 (S1PR1) modulators had been approved by FDA for treating relapsing-remitting MS (RRMS) and show good efficacy. The PET with a imaging agent to measuring of S1PR1 expression my provide an innovative biomarker to predict, diagnose, and monitor the progression of MS, as well as valuate the efficacy of treating RRMS and other inflammatory diseases using S1PR1 inhibition strategy.

PI_NAMEs: BENZINGER, TAMMIE LEE SMITH;TU, ZHUDE  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acute;Address;Adverse event;Affect;Amines;Autoimmune;Autoimmune Responses;Autopsy;Biodistribution;Biological Markers;blood-brain barrier crossing;Brain;Brain imaging;Cells;Central Nervous System;Cervical spine;Chemistry;Clinical;clinical investigation;Clinical Trials;cost estimate;Custom;Cyclic GMP;Cyclotrons;Data;data acquisition;Dedications;Demyelinations;Diagnosis;Direct Costs;Disease;Dose;dosimetry;Drug Kinetics;Endothelial Cells;Evaluation;experience;Experimental Autoimmune Encephalomyelitis;Facilities and Administrative Costs;FDA approved;first-in-human;Fluorine;Funding;Genetic Transcription;Goals;gray matter;healthy volunteer;High Pressure Liquid Chromatography;Human;human imaging;human study;human subject;Image;imaging agent;imaging study;Imaging Techniques;Immune;Immune response;In Vitro;in vivo imaging;Inflammation;Inflammatory;Inflammatory Infiltrate;Injections;innovation;Investigation;Kinetics;Label;Lead;Lesion;Ligands;lipophilicity;Liver;lymph nodes;Lymphocyte;Measurement;Measures;Mediating;metabolic abnormality assessment;Methods;Modeling;Molecular Structure;Monitor;mRNA Expression;Multiple Sclerosis;multiple sclerosis patient;Neurodegenerative Disorders;neuroinflammation;nonhuman primate;Organ;Oxides;Pathway interactions;Patients;Phase;Plasma;Positron-Emission Tomography;Procedures;Process;protein expression;radiation absorbed dose;Radiochemistry;radiotracer;Rattus;Relapsing-Remitting Multiple Sclerosis;repaired;response;Running;safe patient;Safety;Sampling;scale up;screening;Sphingosine-1-Phosphate Receptor;Testing;Tissues;Toxic effect;Tracer;trafficking;United States;uptake;Validation;white matter;X-Ray Computed Tomography;young adult

PROJECT_TITLE: PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Nutrition

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: RELEVANCE (See instructions): The lipid composition of cell membranes must be tightly regulated. Enzymes called Ubiquitin E3 ligases are embedded within the membrane and respond to changes in lipid levels by selectively labeling other proteins involved in lipid production for degradation. This proposal will study the biophysical and biochemical basis for how the lipid membrane composition regulates the activity of these enzymes.

PI_NAMEs: KOBER, DANIEL LUKE (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Anabolism;Back;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biology;biophysical analysis;Biophysics;career;Cell membrane;Cells;Cellular biology;Ceramides;Cholesterol;Complex;Cryoelectron Microscopy;Detection;Dissection;Endoplasmic Reticulum;Environment;enzyme activity;Enzymes;experimental study;Feedback;Feeds;Genetic Transcription;Human;In Vitro;insight;Instruction;Investigation;Knowledge;Label;life span;Lipid Binding;lipid metabolism;Lipids;Mammalian Cell;Membrane;membrane activity;Membrane Lipids;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolism;Mixed Function Oxygenases;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;Organelles;Pathway interactions;Production;protein degradation;protein function;Proteins;proteostasis;Regulation;response;RNF139 gene;Role;Scientist;sensor;serine palmitoyltransferase;Specificity;Sphingolipids;Squalene;Sterols;Stimulus;Substrate Interaction;System;Techniques;Testing;therapy development;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: The mechanistic basis for targeted protein degradation in lipid metabolism


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative We are studying how mutations in the HCFC1 gene cause abnormal brain development and disease. We believe the results of this study will identify future therapeutic targets for the treatment of brain disease.

PI_NAMEs: CASTRO, VICTORIA L (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Achievement;Adult;AKT inhibition;Alleles;Animals;Award;Behavior;Behavioral;Binding;Brain;brain abnormalities;Brain Diseases;Cell Count;Cell Differentiation process;Cell Proliferation;Cell Separation;cell type;chromatin immunoprecipitation;Cobalamin;cofactor;Complex;congenital anomaly;critical period;Data;Densitometry;Development;Disease;Epilepsy;Fellowship;Fishes;Flow Cytometry;Fluorescence-Activated Cell Sorting;FRAP1 gene;Future;Gene Expression;Genes;Genetic Transcription;Germ Lines;Goals;Hereditary Disease;Heterozygote;host cell factor C1;Human;Image;Impairment;In Vitro;in vivo;inhibitor;Intellectual functioning disability;Intractable Epilepsy;knock-down;Knowledge;Label;Larva;Link;loss of function mutation;Manuscripts;Metabolism;Molecular;Molecular Biology;motor disorder;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;mutant;Mutation;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurologic;neuron development;Neurons;Neurosciences;Neurosphere;Nonsense Mutation;novel;Orthologous Gene;Pathway interactions;Pentylenetetrazole;Phase;Phenotype;Phosphorylation;PIK3CG gene;Postdoctoral Fellow;Predisposition;Preparation;prevent;professor;Proliferating;promoter;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Reporter Genes;Research;Role;S phase;Science;Seizures;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Sirolimus;skills;Sorting;stem cells;Syndrome;Techniques;Testing;therapeutic target;Time;Training;Training Programs;transcription factor;transcriptomics;Transgenic Organisms;upstream kinase;Western Blotting;Zebrafish

PROJECT_TITLE: Gene regulatory mechanisms governed by the ASXL1/HCF1/OGT complex during neurogenesis


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Raptor is the defining subunit of the mTORC1 complex, which functions as a master regulator of cellular metabolism. We have recently discovered a novel conditional loss-of-function mutation in the nematode C. elegans Raptor that confers improved survival from hypoxic injury. We will use the unique advantages of this mutant for genetic, cell biological, metabolomic, and proteomic approaches in C. elegans to define the mechanisms whereby Raptor controls hypoxic injury.

PI_NAMEs: CROWDER, C. MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Affect;Aging;Alleles;Autophagocytosis;Biochemical;Biological;Biological Assay;Biological Process;Biology;Caenorhabditis elegans;Cancer Biology;candidate identification;causal variant;Cell Death;Cell Hypoxia;Cell Physiology;Cells;Chromosome Mapping;Chronic;Clinical;Complex;conditional mutant;CRISPR/Cas technology;Data;Defect;Development;experimental study;forward genetics;Foundations;FRAP1 gene;Future;gain of function;Generations;Genes;Genetic;genetic approach;genetic manipulation;genome sequencing;Growth;Hypoxia;improved;inhibitor;Injury;knock-down;Label;Lesion;loss of function;loss of function mutation;Malignant Neoplasms;Mammals;Mediating;Metabolism;metabolomics;Methods;Modeling;Mutagenesis;mutant;Mutate;Mutation;mutation screening;Names;Nature;Nematoda;novel;Nutrient;Orthologous Gene;Output;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphorylation;Protein-Serine-Threonine Kinases;Proteins;Proteome;Proteomics;Publishing;Purine-Nucleoside Phosphorylase;Reagent;Reporter;Reporting;Resistance;response;RNA Interference;Role;Serine;Signal Pathway;Signal Transduction;Sirolimus;Site;Suppressor Mutations;Temperature;Testing;Time;tool;Translations;whole genome;Work;Yeasts

PROJECT_TITLE: DEFINING RAPTOR-MEDIATED MECHANISMS OF HYPOXIC INJURY

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety;Precision Medicine

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE  As part of the NCI Experimental Therapeutics Clinical Trials Network (ETCTN), the California Cancer  Consortium, consisting of four NCI-Designated Comprehensive Cancer Centers, will conduct early phase clinical  trials of investigational new anticancer agents. Through the use of multi-institutional, multi-disciplinary project  teams, the CCC will identify improved approaches to the development of novel anticancer agents that capitalize  on molecular characterization of cancers, while also providing the recommended dose and early evidence for  the therapeutic activity of these agents. Collectively, these efforts will expedite development of urgently needed  new drugs to treat patients with cancer.

PI_NAMEs: COLEVAS, A. DIMITRIOS;DANILOV, ALEXEY V. (contact);LARA, PRIMO N.;LENZ, HEINZ JOSEF

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Acceleration;Adherence;Aftercare;Bioinformatics;Biological Markers;Biopsy;Biostatistics Core;California;Cancer Center;cancer therapy;Cancer Therapy Evaluation Program;career;career development;Cell Cycle Regulation;Cities;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;Clinical Trials Support Unit;Collaborations;Combined Modality Therapy;Communication;Comprehensive Cancer Center;Contracts;Credentialing;Data;Data Coordinating Center;design;Development;Disease;DNA Repair;Dose;Drug Kinetics;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;Eligibility Determination;Ensure;Environment;Fellowship;Funding;Goals;Image;Immunooncology;improved;Individual;Infrastructure;innovation;insight;Institution;Internet;Interventional radiology;Investigational Drugs;Investigational Therapies;Joints;Laboratories;Lead;Leadership;Letters;Malignant Neoplasms;medical specialties;meetings;member;Mentors;Mentorship;Methodology;Minority Groups;minority patient;Molecular;Molecular Target;Monitor;multidisciplinary;National Cancer Institute;neoplastic cell;non-invasive imaging;Normal tissue morphology;novel;novel anticancer drug;novel therapeutics;Organizational Affiliation;Outcome;Pathology;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;Pharmacology;Phase;Phase IV Clinical Trials;Policies;pre-clinical;Prediction of Response to Therapy;Principal Investigator;Procedures;Productivity;programs;Protocols documentation;Publishing;rare cancer;Recommendation;Recording of previous events;Research;Research Personnel;Resources;Safety;Science;Signal Transduction;Signal Transduction Pathway;Site;symposium;Therapeutic;Time;timeline;Toxic effect;Translational Research;translational scientist;tumor;tumor immunology;tumor microenvironment;U-Series Cooperative Agreements;Universities;Validation;Veins

PROJECT_TITLE: Phase 1 and 2 Molecular and Clinical Pharmacodynamic Trials ETCTN


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Mutations in the gene POU4F1 cause a childhood-onset ataxia, which is a condition with lack of coordination of voluntary body movements. We propose to study this disorder using cellular models of the developing human brain via the generation of 2D neuronal cultures and 3D brain organoids derived from human pluripotent stem cells with and without a POU4F1 mutation. The gene expression profiles of the wild-type and mutant cells will be compared.

PI_NAMEs: MARRO, SAMUELE G.;WEBB, BRYN D (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Abnormal coordination;Address;Adult;Affect;Afferent Neurons;Alleles;Animal Model;ATAC-seq;Ataxia;Atrophic;Biology;Brain;Cell Maintenance;Cell model;cell motility;Cells;Cerebral cortex;Childhood;Chromatin;Clinical;Clinical assessments;Computational Technique;Data;density;Development;Diagnosis;differentiation protocol;directed differentiation;Disease;early onset;Epigenetic Process;Equilibrium;Exhibits;exome sequencing;experimental study;fetal;Fibroblasts;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Techniques;Genetic Transcription;genome-wide;Genotype;global developmental delay;Goals;Health Care Costs;Heterozygote;Human;human induced pluripotent stem cells;human pluripotent stem cell;Image;Immunofluorescence Immunologic;Impairment;improved;in vitro Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited Spinocerebellar Degenerations;insight;Intellectual functioning disability;Intellectual impairment;Intention Tremor;Learning Difficulty;loss of function;Loss of Heterozygosity;Mediating;Microelectrodes;Molecular;Molecular Abnormality;Molecular Genetics;Morphology;Movement;multidisciplinary;Mus;Muscle hypotonia;mutant;Mutation;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neurogenesis;Neurologic;neuron loss;Neuronal Differentiation;neuronal excitability;neuronal survival;Neurons;novel;Organoids;overexpression;Pathogenicity;patient registry;Patients;Peripheral;Phenotype;Play;POU Domain;Procedures;Production;programs;Property;Records;Reporting;Role;Sensory;Specific qualifier value;Speech Delay;stem cell model;Synapses;Syndrome;Technology;Testing;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Role of POU4F1 in a Novel Form of Ataxia

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Malaria is a serious and often fatal infectious disease, posing an enormous global health challenge with over 250 million cases per year and more than 600,000 deaths in year 2020. Our goal is to develop small chemical molecules that trick malaria parasites into producing multiple versions of an inhibitor of one of their own essential enzyme complexes, consequently overcoming resistance. Successful completion of the proposed studies will provide novel anti- malarial therapeutics.

PI_NAMEs: LIN, GANG  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Active Sites;Africa;African;analog;Anti-malarials;Artemisinins;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Availability;Cells;Cessation of life;Chemicals;Child;Clinical;Combined Modality Therapy;Communicable Diseases;cytotoxicity;detection limit;Distal;Drug Combinations;Drug Kinetics;Drug resistance;efficacy study;efficacy testing;Exposure to;Frequencies;global health;Goals;Hemin;high risk;HIV;humanized mouse;Hybrids;improved;In Vitro;in vivo;Infection;inhibitor;Investigation;lead optimization;Life Cycle Stages;Lipids;Malaria;Malignant Neoplasms;Modeling;mouse model;multicatalytic endopeptidase complex;multidrug tolerance;Multienzyme Complexes;Mus;mutant;Mutation;novel;Oligopeptides;Oral;Organism;oxidative damage;Parasite resistance;Parasites;Penetration;Peptides;Pharmaceutical Preparations;pharmacophore;Plasmodium;Plasmodium falciparum;Point Mutation;prevent;Prevention;Process;Prodrugs;Property;Proteasome Inhibitor;Proteins;Recrudescences;Reporting;Resistance;Resistance development;resistance mechanism;resistance mutation;Site;Southeastern Asia;standard care;Structure-Activity Relationship;success;synergism;System;Testing;Therapeutic;Time;Tissues;Toxic effect;tuberculosis treatment;Ubiquitin;Vertebral column

PROJECT_TITLE: Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Machine Learning and Artificial Intelligence;Neurosciences;Radiation Oncology;Rare Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: This study will perform novel released tumor DNA (rtDNA) and protein-based APT-weighted MRI assays on newly diagnosed glioblastoma patients. We will determine the accuracy of combined rtDNA/APT indices in identifying disease recurrence following the therapy. If our rtDNA/APT investigation is successful, it will allow clinicians to monitor response more accurately (as a result, potentially obviating the need for invasive neurosurgical procedures) and alter therapies more timely.

PI_NAMEs: BETTEGOWDA, CHETAN ;JIANG, SHANSHAN  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Aftercare;Amides;Aneuploidy;Attention;Bioinformatics;Biological Assay;Biological Markers;Biopsy;burden of illness;Cells;Cerebrospinal Fluid;Characteristics;chemoradiation;Clinical;Complex;Correlation Studies;Data;deep learning;deep learning model;Diagnostic;diagnostic strategy;Disease;DNA;DNA analysis;FDA approved;Genetic Markers;Genetic Status;Genomics;Genotype;Glioblastoma;Glioma;Goals;Heterogeneity;Human;Image;improved;indexing;Individual;Investigation;liquid biopsy;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Methods;MGMT gene;minimally invasive;Modality;Molecular;molecular imaging;Monitor;MRI Scans;multimodality;Mutation;Names;neurosurgery;Neurosurgical Procedures;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;Patient Care;Patients;Pattern;Phenotype;Plasma;pre-trained transformer;predictive modeling;Primary Brain Neoplasms;Prognosis;prognostic;Progression-Free Survivals;Proteins;Protocols documentation;Protons;radiomics;recruit;Recurrence;Recurrent disease;Recurrent tumor;Reporting;response;Risk;Sampling;Signal Transduction;Somatic Mutation;standard care;success;Techniques;temozolomide;Text;Time;Tissue Sample;Tissues;tool;treatment effect;treatment response;tumor;Tumor Burden;tumor DNA;tumor progression;Tumor Tissue;Tumor-Derived

PROJECT_TITLE: Integrating circulating tumor DNA assay and protein-based MRI to accurately monitor glioma therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Giardia is a widespread intestinal parasite, and both parasite colonization of the host gut and transmission of cysts between hosts are key aspects of Giardia’s life cycle. Proteins called transcription factors (TFs) are essential for parasite growth, development, and survival in the host. This research seeks to identify and evaluate key TFs regulating parasite responses in the host, and this research could lead therapies that prevent or decrease the severity of Giardia infection.

PI_NAMEs: DAWSON, SCOTT C (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Animals;biological adaptation to stress;Biological Assay;Biology;bZIP Domain;Categories;cDNA Library;Cell Cycle;Cell division;Cell Nucleus;Communities;Complementary DNA;CRISPR interference;Cues;Cyst;Defect;density;Development;diarrheal disease;Diet;Distal;DNA;DNA Binding;DNA Binding Domain;DNA-Binding Proteins;DNA-Protein Interaction;druggable target;Duodenum;Epithelium;Eukaryota;excystation;extracellular;Feces;Future;Gene Expression;gene repression;Genes;Genetic;Genetic Markers;Genetic study;Genetic Transcription;Genome;genome-wide;Giardia;Giardia lamblia;global health;Goals;Growth;Guide RNA;gut colonization;host colonization;Hour;Human;Hybrids;Immune;Immune response;in vivo;Infection;Ingestion;Interphase;Intestinal parasite;knock-down;Knock-out;Knowledge;Lead;Libraries;Life Cycle Stages;Luciferases;Mediating;Meiosis;Metabolic;Molecular Genetics;Motility;mutant;novel;Nutrient;Oxidants;Oxidation-Reduction;Parasites;Pathogenesis;Periodicals;Phenotype;prevent;promoter;Protein Binding Domain;Proteins;Regulator Genes;Reporting;Research;Resources;response;Robotics;Role;screening;Severities;Small Intestines;Stress;System;Testing;tool;Transcription Coactivator;transcription factor;transcription regulatory network;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;transmission process;Yeasts

PROJECT_TITLE: High-throughput, untargeted approaches to identify and define the functions of transcription factors regulating key life cycle transitions in Giardia

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: PROJECT NARRATIVE Aggregation of α-synuclein at synapses, the functional contacts between neurons, has been linked to cognitive deficits and dementia in Parkinson’s disease and Dementia with Lewy Bodies. The proposed studies will provide insights into the early events and mechanisms leading to synaptic dysfunction in α-synuclein-related diseases. Understanding these mechanisms will help advance the development of therapies aimed at improving synapse function in neurodegenerative diseases.

PI_NAMEs: ROMAN-VENDRELL, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acute;Address;Advanced Development;Affect;alpha synuclein;Appearance;Back;Brain;Cell membrane;Cells;cellular targeting;Clathrin;coated pit;Cognitive deficits;Data;Defect;Dementia with Lewy Bodies;Diameter;dimer;Disease;Dyes;Early Endosome;Electrons;Electrophysiology (science);Endocytosis;Endosomes;Equilibrium;Event;Functional disorder;Human;Human body;human disease;human subject;Image;Immunofluorescence Immunologic;Impairment;improved;Individual;innovation;insight;Knowledge;Laboratory Research;Lampreys;late endosome;Link;Measures;Mediating;Membrane;Methods;Microscopic;Modeling;Molecular;Molecular Analysis;Molecular Weight;monomer;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;neurotoxicity;neurotransmission;novel;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathology;Phenotype;Physiological;Physiology;Positioning Attribute;Postdoctoral Fellow;presynaptic;Process;Proteins;Recombinants;Recycling;Research;Research Personnel;Structure;Synapses;synaptic function;Synaptic Vesicles;synuclein;synucleinopathy;Techniques;Testing;therapy development;trafficking;uptake;Vesicle;Work;Yeasts

PROJECT_TITLE: Mechanisms of Endosomal Dysfunction at Synapses in A-Synuclein Pathology


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Randomized controlled trials demonstrated a reduction in lung cancer mortality with annual lung cancer screening with low dose computed tomography, yet real-world populations eligible for and undergoing lung cancer screening differ substantially from trial populations. By leveraging data from a randomized controlled trial and multiple real-world data sources, the proposed study will evaluate the benefits and harms of lung cancer screening in clinical practice settings with a focus on optimizing internal and external validity by applying novel causal inference methodologies. The proposed research is consistent with the Cancer Moonshot Initiative of the National Cancer Institute, which issued a call to action on cancer screening and early detection in February 2022.

PI_NAMEs: HENDERSON, LOUISE ;LUND, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adherence;Affect;Behavioral;Behavioral Risk Factor Surveillance System;Breast Cancer Detection;cancer therapy;Characteristics;clinical practice;Clinical Trials;colon cancer screening;Communication;cost;Data;Data Set;Data Sources;Decision Aid;Decision Making;design;Development;Diagnostic Procedure;Early Diagnosis;Effectiveness;Eligibility Determination;Equilibrium;evidence base;Female;follow-up;General Population;human old age (65+);improved;Individual;Intervention;intervention effect;Left;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medicare claim;Methodology;Methods;mortality;National Cancer Institute;National Health Interview Survey;North Carolina;novel;Observational Study;Outcome;Outcome Assessment;Patients;Pattern;Policy Maker;Population;Population Characteristics;practice setting;Procedures;Provider;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Registries;Research;Research Personnel;Risk Factors;routine screening;Sampling;screening;Screening for cancer;screening guidelines;screening program;Selection Bias;Selection for Treatments;shared decision making;Smoking;Subgroup;Surveys;Time;tool;trial enrollment;United States Preventative Services Task Force;Update;uptake;Work

PROJECT_TITLE: Applying causal inference methods to improve estimation of the real-world benefits and harms of lung cancer screening

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Nanotechnology;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE In this project we propose to develop and apply novel and established position emission tomography methods for preclinical assessment of stress-induced immune reprogramming in cardiovascular disease. Imaging will be performed in a longitudinal fashion to study the immediate and long-term effects of psychosocial stress.

PI_NAMEs: VAN LEENT, MANDY MARIA THERESIA (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: 18F-fluorothymidine;Acute;acute stress;Affect;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;Back;beta-Chemokines;Biological Assay;Bone Marrow;Brain;Cardiac;Cardiovascular Diseases;cardiovascular imaging;Catecholamines;Cell Physiology;Cell Proliferation;Cells;chemokine receptor;Chronic;Chronic stress;Coronary Arteriosclerosis;Data;Development;Disease Progression;Epigenetic Process;Event;Extravasation;Flow Cytometry;fluorodeoxyglucose positron emission tomography;G9a histone methyltransferase;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Homing;hypothalamic-pituitary-adrenal axis;Image;imaging approach;imaging modality;Imaging Techniques;Immune;Immune response;Immune system;Immunity;in vivo;Inflammation;Inflammatory;innovation;ITGAM gene;Label;Leukocytes;Link;Long-Term Effects;Lymphocyte;Metabolic;metabolic abnormality assessment;Metabolic Marker;Methods;migration;Molecular Biology;Molecular Immunology;monocyte;Monocytosis;Motor Cortex;mTOR inhibition;Mus;Myeloid Cells;nanobiologic;nanobodies;nanotherapy;neutrophil;non-invasive imaging;novel;Nuclear;nuclear imaging;Organ;Phenotype;Positioning Attribute;Positron-Emission Tomography;pre-clinical assessment;preclinical imaging;Process;Production;Proliferating;Psychosocial Stress;Recovery;Research;response;serial imaging;Signal Transduction;spatiotemporal;Stress;Sympathetic Nervous System;Techniques;tomography;Tracer;Training;western diet;White Blood Cell Count procedure;Withdrawal

PROJECT_TITLE: Preclinical imaging of immune responses to chronic stress

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Asthma;Infectious Diseases;Lung

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Upper respiratory virus infection (URVI) is responsible for 80% of asthma attacks; however, the underlying mechanisms remain poorly understood. This project is proposed to dissect the cellular and molecular mechanisms undelying the nose -lung cross talk, particularly how URVI causes asthma attacks. Findings from this research are expected to lead to not only novel preventive and therapeutic strategies for asthmatics, but also to define nasal mucosal immune system and subsequently facilitate nasal vaccine development against airborne pathogens. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: HUA, XIAOYANG  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: adaptive immunity;Adjuvant;Adoptive Cell Transfers;Affect;airway hyperresponsiveness;airway inflammation;Allergens;Antigen-Presenting Cells;Antigens;Asthma;asthma exacerbation;asthmatic;B-Lymphocyte Subsets;B-Lymphocytes;Bone Marrow;Bronchoalveolar Lavage Fluid;CCL2 gene;CCL7 gene;Cells;chemokine;Coronavirus;cytokine;Data;Development;Disease;Dose;draining lymph node;Exposure to;Gene Modified;Goals;Homing;Human;humoral immunity deficiency;IL5 gene;Immune;Immune response;Immunity;Immunocompromised Host;Immunologics;Immunology;Immunomodulators;Infection;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Lung;Lung infections;lymph nodes;Measures;migration;Molecular;monocyte;Mucosal Immune System;Mucous body substance;Mucous Membrane;Mus;Natural Immunity;Nose;novel;Outcome;pathogen;Patients;Physiology;Play;Preventive;Production;Pyroglyphidae;recruit;Reporting;Research;respiratory infection virus;Respiratory Mucosa;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Reverse Transcriptase Polymerase Chain Reaction;Rhinovirus;Structure of mucous membrane of nose;Therapeutic;trafficking;vaccine development;vaccine immunotherapy;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Shedding

PROJECT_TITLE: The nose-lung cross talk in upper respiratory virus infection induced asthma exacerbations

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Rigorous clinical trials are essential for the translation of scientific discoveries to improve the health of children and adults with neurological disease. The University of Rochester and its neuroscience investigators have the clinical trials experience, expertise, and track record to serve as an exemplary and high-quality Clinical Site to ensure the success of NeuroNEXT.

PI_NAMEs: HOLLOWAY, ROBERT G. (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Achievement;Adult;Affect;anti-racism;Area;Award;career development;Child;Child Health;clinical research site;Clinical Sciences;clinical trial readiness;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community engagement;Dentistry;digital tool;Ensure;Equity;experience;Family;Fortification;Fostering;Funding;Future;gene therapy;gene therapy clinical trial;Gene therapy trial;gene-targeted therapy;Genes;Goals;Grant;improved;innovation;Intellectual and Developmental Disabilities Research Centers;International;Investigational Therapies;K-Series Research Career Programs;Lead;Leadership;Letters;Medical center;medical schools;member;Mentors;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Pediatric Neurology;Performance;Positioning Attribute;post-doctoral training;Process;Productivity;programs;Qualifying;Questionnaires;Rare Diseases;recruit;Research;Research Personnel;Resources;response;Site;skills;Specialist;success;System;targeted therapy trials;Training;training opportunity;Training Programs;Translation Process;Translational Research;Translations;Trust;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: University of Rochester Clinical Site within the NEXT Network of Clinical Trials


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Despite the functional importance, studies of long-distance human brain circuitry development and connectivity have been significantly hindered due to lack of suitable microphysiological platforms. To fill the critical gap, we will reconstruct human cortico-striatal circuits in both two and three dimensions by developing a novel microfluidic chip together with lineage-specific neuronal differentiation approaches and utilize such new paradigm to study axon projections, global network dynamics, and high-order brain function e.g., brain waves during human brain circuitry development. Completion of the proposed studies will present an innovative approach to reconstitute well-defined long-distance human brain circuits and gain novel insights into how cortical inputs drive human striatal function, laying the foundation for future pathological studies of patients- derived brain circuitry models such as schizophrenia and eventually for developing novel therapies for disease via targeting dysfunctional brain circuits.

PI_NAMEs: GUO, ZIYUAN  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: 3-Dimensional;Axon;Behavior;Benchmarking;Biological Assay;Biology;Brain;brain circuitry;brain dysfunction;Cells;Coculture Techniques;Cognition;Corpus striatum structure;Coupling;Development;Disease;Electrodes;Electrophysiology (science);Etiology;Foundations;Functional disorder;functional outcomes;Future;Glutamates;Grant;Human;human pluripotent stem cell;imprint;In Vitro;in vivo;innovation;insight;Microelectrodes;Microfluidic Microchips;Microfluidics;microphysiology system;Modeling;Monitor;neural;neural circuit;Neural Interconnection;neural network;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;Organoids;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;reconstitution;reconstruction;Resolution;response;Rodent;Schizophrenia;Structure;Surface;System;transmission process;two-dimensional

PROJECT_TITLE: Developing 3D brain circuits on-a-chip for in vitro study of human cortico-striatal circuitry development and connectivity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Infectious Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Infectious diseases are particularly dangerous for individuals with compromised immune systems due to cancer, transplantation or other conditions, or medications that weaken the immune system. Immunocompromised persons are more susceptible to initial infection, less capable of successfully battling infections, and therefore more likely to have severe complications from infections that are rarely seen in the general population. We seek continued support to train two new physician-scientists and/or post-doctoral PhD scientists each year for three years in three research areas that will advance knowledge of the biology, pathogenesis, diagnosis, prevention, and treatment of infectious diseases in immunocompromised persons.

PI_NAMEs: BOECKH, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Immunocompromised Host;Training Programs

PROJECT_TITLE: Training Program in Infectious Diseases in the Immunocompromised Host

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


PHR: NARRATIVE We have identified a population of neurons in the brain that can be activated to induce torpor, a form of hibernation characterized by low body temperature and metabolic rate. Our preliminary data suggests that this synthetic torpor may reduce or prevent the progression of brain injury after stroke. We propose to confirm these preliminary findings and identify the metabolic pathways involved in cerebroprotection to develop novel treatment strategies for patients recovering from stroke and other forms of brain injury.

PI_NAMEs: LANDSNESS, ERIC C (contact)

PROJECT_TERMS: Acute;Address;Adult;Affect;behavior test;behavioral outcome;Biology;Body Temperature;Brain;Brain Injuries;Caring;Ceramides;cerebroprotection;Citric Acid Cycle;Clinical Trials;Clozapine;cognitive function;Data;Development;Event;experience;Future;Genetic;Goals;Hibernation;Hour;Impairment;improved;Induced Neurons;Infarction;Injury;Intervention;Investigation;Ischemia;Ischemic Stroke;kappa opioid receptors;Knowledge;Lipids;Long term disability;Measures;Medial;Mediating;medical specialties;Metabolic;Metabolic Pathway;metabolic rate;Metabolic stress;Metabolism;metabolomics;Middle Cerebral Artery Occlusion;Modeling;mortality;Motor;Mus;natural hypothermia;neural circuit;Neurons;neurovascular unit;novel;nucleotide metabolism;Outcome;Oxides;Pathway interactions;Patient-Focused Outcomes;Patients;Physiological;Population;post stroke;Pre-Clinical Model;Preoptic Areas;prevent;Reporting;Research;research study;response;Role;Sensory;Stress;Stroke;stroke patient;stroke survivor;Succinates;Testing;Therapeutic;thrombolysis;tool;translational study;treatment strategy;United States

PROJECT_TITLE: Torpor for cerebroprotection

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative  Sexual minorities (e.g., gay, lesbian, and bisexual adults) have significantly greater risk for obesity, asthma, diabetes, cardiovascular disease, and some cancers compared to heterosexuals. However, biomarkers of risk, modifiable behavioral and psychological factors, and intersectional identities contributing to these health disparities are unknown. With a robust sample size and strong representation across different sexual identities, NCHAT-BIO offers a uniquely comprehensive and methodologically rigorous investigation of stress biology among sexual minorities in the US, permitting novel tests of mechanisms linking stress, health, and intersectionality within a minority stress framework.

PI_NAMEs: CHRISTIAN, LISA MICHELLE (contact);MORGAN, ETHAN

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: 18 year old;access restrictions;Accounting;Acute;Address;Adult;Affect;Age;Age Years;Anxiety;Articulation;Asian population;Asthma;Behavioral;biobehavior;Biological;Biological Assay;Biological Markers;Biology;Black Populations;Blood;C-reactive protein;Cardiovascular Diseases;Cellular Immunity;Chronic;Chronic Disease;Chronic stress;cohort;Cohort Studies;Color;Complex;Couples;Data;Data Collection;Databases;Diabetes Mellitus;Diet;Discrimination;Dryness;EBV reactivation from latency;Ethnic Origin;Exercise;Exhibits;experience;Funding;Future;Health;Health behavior;health disparity;health disparity populations;Heterosexuals;Human Herpesvirus 4;Immune;immune function;Immune system;Immunologic Markers;immunoregulation;Impairment;Individual;Inflammation;inflammatory marker;Interleukin-6;internalized stigma;intersectionality;Intervention;Investigation;Knowledge;Latinx population;Lesbian Gay Bisexual;Link;Literature;Malignant Neoplasms;Measures;Mediating;men;Mental Depression;Methodology;microaggression;minority stress;minority stressor;modifiable behavior;mortality;National Institute of Child Health and Human Development;Not Hispanic or Latino;novel;Obesity;obesity risk;optimism;Outcome;pandemic disease;Participant;Pathway interactions;Pattern;Personal Satisfaction;Population;Psychological Factors;Public Health;Race;Recording of previous events;Reduce health disparities;Reporting;Research;Resources;Risk;risk prediction;Sample Size;Sampling;sexual identity;sexual minority;sexual minority stress;Sleep disturbances;social stigma;Spottings;Stigmatization;Stress;stressor;substance use;Testing;Time Study;time use;United States National Academy of Sciences;Victimization;Violence;virtual;Woman

PROJECT_TITLE: The National Couples Health and Time Use Stress Biology Study (NCHAT-BIO): Biobehavioral Pathways to Population Health Disparities in Sexual Minorities

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


PHR: PROJECT NARRATIVE For patients with thoracic aortic aneurysms (TAA), prosthetic graft replacement of the ascending aorta eliminates dissection risk in graft-replaced regions, but risk increases in the distal aorta - especially in patients with genetically triggered aortopathies, who undergo graft replacement at lower thresholds, higher frequency, and younger age. Prosthetic grafts differ from native aortic shape and stiffness, and thus alter flow to distal aortic regions. This study will use cardiac MRI and computational modeling to test if prosthetic grafts drive adverse distal aortic remodeling and dissection, so as to inform risk stratification and therapy with current grafts, and guide development of new graft materials to accommodate for differential aortic compliance in patients with genetically triggered TAA – towards the goal of improved outcomes after proximal graft replacement surgery.

PI_NAMEs: GAUDINO, MARIO FL;WEINSAFT, JONATHAN W. (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 4D MRI;Address;Adoption;Age;Aneurysm;Aorta;Aortic Diseases;ascending aorta;Attenuated;attenuation;biomarker identification;Biomechanics;Blood;Blood Vessels;cardiac magnetic resonance imaging;Cessation of life;Characteristics;Clinical;clinical application;clinical predictors;clinical prognosis;Collaborations;Compensation;Computer Models;Computer Simulation;dacron;Data;Data Analyses;design;Development;Diffuse;Disease Progression;Dissection;Distal;Elasticity;Electric Capacitance;Event;follow-up;Four-dimensional;Frequencies;Future;Genetic;Geometry;Goals;heart imaging;hemodynamics;Image;implantation;improved outcome;insight;Intervention;Length;Life;Link;Liquid substance;Marfan Syndrome;mechanical load;Mechanical Stress;Medical;member;millimeter;Operative Surgical Procedures;Organ failure;Patients;personalized medicine;Persons;Phase;Physiology;Polyethylene Terephthalates;Postoperative Period;Pre-Clinical Model;Productivity;Prognosis;prognostic;Property;Prospective cohort;Prosthesis;prototype;Registries;Reporting;Research;Resected;Residual state;response;Risk;risk stratification;Shapes;shear stress;simulation;standard of care;stem;Structure;Technology;Testing;Thinness;Thoracic Aortic Aneurysm;Tissues;United States;Vascular remodeling

PROJECT_TITLE: Towards Personalized Prosthetic Graft Replacement for Genetically Triggered Thoracic Aortic Aneurysms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(02)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: ARLINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative The proposed work is aimed at deciphering the processes governing labral tear-mediated tissue damage while developing a new and complementary technology for treating glenoid labral tears with improved healing outcome. The results will lead to creation of a novel, injectable, in situ-forming, and biomolecule-releasing adhesive scaffold which can reduce inflammatory response-associated tissue damage and enhancing labral tissue regeneration by eliciting the regenerative activities of endogenous labral and progenitor cells at the site of the labral tear.

PI_NAMEs: TANG, LIPING  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Adhesions;Adhesives;Animal Model;Anterior;Binding;bone;bone healing;Cartilage;Cell Separation;Cell Therapy;Cells;Chemistry;Chitosan;chronic shoulder pain;clinical translation;Complementary therapies;Cyclooctenes;cytotoxicity;design;disability;Effectiveness;Engineering;Extracellular Matrix;Extracellular Matrix Proteins;Fibrin Tissue Adhesive;Fibrocartilages;Gel;Growth Factor;healing;Histocompatibility;Human;Hydrogels;implantation;improved;In Situ;In Vitro;in vivo;in vivo regeneration;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Injectable;Injections;injured;Injury;Intervention;Investigation;Joint structure of shoulder region;Knowledge;Laboratories;Lesion;Literature;Location;Mediating;Methods;migration;Modeling;Morphology;Muscle;Natural regeneration;Needles;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pain;Physical therapy;Platelet-Derived Growth Factor;Process;Production;progenitor;Proliferating;Property;Publishing;Rattus;Recovery of Function;recruit;Recurrence;regenerative;regenerative cell;regenerative tissue;release factor;repaired;Reporting;Residual state;response;Rotator Cuff;scaffold;seal;Series;Shoulder;Site;Source;stem cell biomarkers;stem cell migration;stem cells;Structure;Surgical sutures;System;Technology;Testing;Time;Tissue Engineering;tissue injury;Tissue Model;tissue regeneration;Tissues;Work

PROJECT_TITLE: Biomolecule releasing adhesive for cell-mediated labral repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Pathogen-specific PET imaging probes will identify and quantify extent of infection of K. pneumoniae and P. aeruginosa in mouse coinfection models, differentiate viral from bacterial AECOPD, and serve as an effective quantitative imaging tool to track responsiveness to antibiotic treatment.

PI_NAMEs: KOTAGIRI, NALINIKANTH  (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Acinetobacter;Acute;Affinity;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;Bacterial Model;Binding;Biodistribution;Biological Markers;Chronic Obstructive Pulmonary Disease;Clinical;clinically relevant;co-infection;Color;Communicable Diseases;Complex;Contrast Media;Copper;Detection;Development;Differential Diagnosis;Disease;disease model;Enterobacter;Enterobacteriaceae;Exhibits;Family;Foundations;Goals;Gram-Negative Bacteria;Hospitalization;imaging agent;Imaging Device;imaging modality;imaging probe;improved;in vivo;in vivo evaluation;Infection;Influenza A Virus, H3N2 Subtype;influenzavirus;Innate Immune System;innovation;Iron;Klebsiella;Klebsiella pneumoniae;Label;Ligands;Lung;Lung infections;Membrane;Membrane Transport Proteins;metal chelator;Metals;Modeling;molecular imaging;Monitor;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;Myositis;new technology;nuclear imaging;Organism;pathogen;Pathogenicity;Patients;Performance;Play;Pneumonia;Positron-Emission Tomography;Property;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;pyochelin;quantitative imaging;Radioisotopes;real-time images;receptor;Reporter;respiratory;Respiratory Failure;Role;screening;Sensitivity and Specificity;Siderophores;Specimen;Sputum;Surrogate Markers;Techniques;technology platform;Time;Treatment Cost;Treatment Efficacy;uptake;Viral;Virus Diseases;X-Ray Computed Tomography;yersiniabactin

PROJECT_TITLE: Siderophore based molecular imaging of pulmonary infections


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Infectious Diseases;Microbiome;Prevention;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project has major public health relevance because diabetic foot ulcers (DFU) remain one of the most common secondary diabetes-related complications and are the leading cause of lower extremity amputation in the United States. Current treatments are ineffective and evidence now demonstrates a surge in major lower extremity amputations and necessitates development of novel treatment avenues and technologies to advance care for this vulnerable population. The main objective of this proposal is to utilize metagenomics next generation sequencing to understand the role of the microbiome in the pathogenesis of DFU and identify new treatments and reduce sequela of DFU.

PI_NAMEs: SCHMIDT, BRIAN M (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adult;Affect;American;Amputation;Antibiotic Therapy;Award;Bacteria;biobank;Biological Markers;biomarker validation;Biometry;candidate identification;career development;Caring;chronic ulcer;Clinical;clinical care;Clinical Research;clinical research site;clinical trial implementation;Clinical Trials;cohort;Communicable Diseases;Complications of Diabetes Mellitus;Consensus;Controlled Study;Cross-Sectional Studies;Data Coordinating Center;Death Rate;Debridement;Dependence;design;Development;Development Plans;diabetes control;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Ecology;Event;evidence base;experience;Foundations;Functional disorder;Future;Genetic Materials;Goals;healing;Health;improved;improved outcome;Individual;ineffective therapies;Infection;Infrastructure;Interruption;Intervention;Intervention Studies;Investigation;Laboratories;Leadership;Longitudinal Studies;Lower Extremity;Mentors;Metagenomics;Michigan;microbial;microbiome;microbiota;microbiota composition;modifiable risk;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Neuropathy;new technology;next generation sequencing;non-diabetic;novel;Observational Study;pathogen;Pathogenesis;patient oriented;Patients;Performance;Physicians;Physiological;Physiology;Podiatry;Positioning Attribute;Practice Guidelines;prevent;Process;programs;public health relevance;Public Health Schools;Research;Research Methodology;Research Personnel;Risk;Risk Factors;risk stratification;Role;Scientific Advances and Accomplishments;Scientist;skills;standard of care;Standardization;Sterile coverings;synergism;targeted treatment;Techniques;Technology;Testing;Therapeutic;tool;Training;United States;Universities;University resources;validation studies;Variant;Vulnerable Populations;wound;wound healing

PROJECT_TITLE: The Role of the Microbiome in Diabetic Foot Ulcers

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Pathogens require iron for growth within host human cells, but the host can prevent pathogens from acquiring this metal. It is not known how pathogens in membrane compartments acquire this resource, or how the human prevents the pathogen from acquiring it. The proposed work will identify the source of this iron, how the iron moves across this membrane, and uncover strategies that prevent pathogens from having unlimited access to this source.

PI_NAMEs: ISBERG, RALPH R. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Bacteria;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Biogenesis;Biology;biophysical analysis;Biophysics;Biosensor;candidate identification;Cell Line;cell type;Cells;Communicable Diseases;Consensus;Coupled;CRISPR/Cas technology;Cryoelectron Microscopy;Crystallography;Cytoplasm;Cytosol;Data;density;Detergents;Development;dimer;Disease;Docking;Electrons;Endoplasmic Reticulum;Environment;Experimental Genetics;experimental study;extracellular;Fire - disasters;Fluorescence;Goals;Growth;Human;Immune;Individual;innate immune function;Iron;Legionella;Legionella pneumophila;Libraries;Link;Macrophage;Maintenance;Measures;Membrane;Metals;microbial;microorganism;Modeling;Molecular;Molecular Conformation;mutant;Mutation;nanodisk;Nutrient;Nutritional;Nutritional Immunity;Organelles;pathogen;pathogenic bacteria;Pathway interactions;Phospholipids;Play;prevent;Process;promoter;Property;protein purification;protein reconstitution;protein transport;Proteins;reconstruction;recruit;Reporter;Research Personnel;Resources;response;Role;Route;sensor;Sequence Analysis;Side;Siderophores;Source;Spin Labels;Starvation;Structure;System;Technology;Testing;Transition Elements;U937 Cells;Vacuole;vesicle transport;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular basis of metal acquisition by an intravacuolar pathogen

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Food allergy is increasing in prevalence in industrialized nations and is often associated with eczema. We will identify cutaneous factors that promote the development of food allergies and determine the mechanism(s) for this effect. Elucidation of mediators of food allergy will have a significant public health benefit in the reduction of the burden of disease.

PI_NAMEs: EISENSTEIN, ANNA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adjuvant;Advisory Committees;Allergens;Allergic;Allergic Disease;Allergic Reaction;Anaphylaxis;Animals;Antigens;Atopic Dermatitis;Basic Science;Biology;Blood;burden of illness;career;career development;cell type;Cells;Chemicals;Child;Chronic;Circulation;Clinical;Clinical Management;Collection;conditional knockout;Cutaneous;Cutaneous Administration;Data;Dendritic Cells;Dermatology;Detergents;Developed Countries;Development;Disease;Eating;Eczema;Emollients;Endocrine;Environmental Risk Factor;Event;experience;Exposure to;Food;food allergen;food antigen;Food Hypersensitivity;Food Preservatives;Goals;Health Benefit;Household Products;human disease;Hypersensitivity;Immune;immune function;Immune response;Immunity;Immunobiology;Immunoglobulins;Immunologic Memory;Immunology;In Vitro;in vivo Model;Incidence;Individual;Industrialization;Injury;insight;interest;Interleukins;intestinal epithelium;Intestines;Investigation;keratinocyte;Knockout Mice;Lead;Mediator;meetings;Mentors;Mentorship;Modeling;Modernization;Molecular;mouse model;Non-Prescription Drugs;novel;novel therapeutic intervention;nuclear factor-erythroid 2;Oral;Oral Ingestion;Pathogenesis;Pharmaceutical Preparations;Physicians;Prevalence;preventive intervention;Principal Investigator;Production;programs;Property;Public Health;receptor;Recombinant Interleukins;Reporting;Research;Research Personnel;Residencies;Risk;Role;Scientist;sensitizing antigen;sensor;Signal Transduction;single-cell RNA sequencing;skills;Skin;skin barrier;skin damage;Soaps;Specificity;Testing;theories;Tissues;Topical application;Training;Training Programs;Translating;Work;Xenobiotics

PROJECT_TITLE: Elucidating the Role of Cutaneous Environmental Factors in the Development of Allergic Disease

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Genetic or pharmacological disruption of brain mTOR activities are frequently associated with disrupted daily rhythms in patients and the mechanisms are unknown. The proposed work will generate new knowledge on a physiological role for mTOR in the brain clock, which will be important for understanding circadian sleep problems in various “mTORopathies” as well as for rational design of next generation mTOR modulators.

PI_NAMEs: CAO, RUIFENG (RAY)  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Actins;Address;Animals;Behavior;Behavioral;Behavioral Assay;Biological Clocks;Bioluminescence;Brain;Brain Diseases;Cell Nucleus;circadian;Circadian Dysregulation;circadian pacemaker;Clinical;conditional knockout;Cytoskeletal Modeling;Data;EIF4EBP1 gene;Environment;environmental change;Event;Exhibits;Exposure to;extracellular;FDA approved;FRAP1 gene;Gene Expression;Genetic;genetic manipulation;Genetic Models;genome-wide;Goals;Hypothalamic structure;inhibitor;innovation;interdisciplinary approach;Knowledge;Light;loss of function;Mammals;Mediating;Mental disorders;Metabolism;microscopic imaging;Molecular;mouse genetics;mRNA Translation;mTORopathies;Mus;Mutant Strains Mice;Nervous System Disorder;next generation;novel;Organism;Pathogenesis;Patients;Periodicity;Pharmaceutical Preparations;pharmacologic;Phase;Photoperiod;photoperiodicity;Physiological;Physiology;polymerization;Polymers;Property;Protein Biosynthesis;protein complex;Proteins;Publishing;rational design;Regulation;Repression;Research;response;Ribosomal Protein S6 Kinase;Role;Running;Signal Pathway;Signal Transduction;Sleep Disorders;Sleep disturbances;Sleeplessness;Slice;suprachiasmatic nucleus;Testing;Therapeutic Effect;Time;Tissues;translation assay;Translations;Western Blotting;Work

PROJECT_TITLE: Mammalian target of rapamycin signaling and the suprachiamatic circadian clock

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Brown adipocytes are associated with metabolic benefits to alleviate diabetes and obesity, but are much less abundant than white adipocytes in humans and hard to obtain in large numbers. We combine our novel technologies for extensive expansion of human adipocytes in culture and for engineering genes in these cells with CRISPR to convert them into brown-like adipocytes. Our project is designed to test the hypothesis that CRISPR-based disruption of two genes in particular--Nrip1 and Pkrar2—will optimally generate human brown adipocytes from abundant human white adipose tissue as a basic step towards therapeutic applications.

PI_NAMEs: CZECH, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agonists;Agonist;Back;Biological Products;Blood Glucose;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical Trials;Closure by clamp;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Complex;Consultations;cost;Coupled;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Department of Defense;design;Development;Diabetes Mellitus;Diabetic mouse;diet-induced obesity;Endotoxins;Energy Metabolism;Engineered Gene;Engineering;experimental study;expression vector;Fasting;Funding;Gene Combinations;Gene Modified;Gene Targeting;Genes;Genetic Transcription;genetically modified cells;glucose tolerance;Goals;Health;Human;Hyperinsulinism;Immune;Immune response;Implant;implantation;improved;In Vitro;in vivo;Incidence;insertion/deletion mutation;Knock-out;Learning;Legal patent;Light;Liver;Mediating;Metabolic;Metabolic Diseases;Methods;Microscopy;mouse model;mRNA Expression;Mus;nerve supply;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;NRIP1 gene;Obese Mice;Obesity;Oxygen Consumption;pandemic disease;Pathway interactions;Patients;Phenotype;Prevention;progenitor;Protein Deficiency;Protein Secretion;Protein Subunits;Proteins;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Sampling;screening;Signal Transduction;small molecule;stem cells;subcutaneous;Suppressor Genes;synergism;Technology;Testing;Therapeutic;Thermogenesis;transcriptome sequencing;Triglycerides;Up-Regulation;Vascularization;Viral Vector;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: CRISPR-enhanced adipocyte browning to improve glucose tolerance in obesity and diabetes


NIH_SPENDING_CATS: Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Narrative The development of therapeutics for diseases, which includes vaccines to fight viruses such as COVID-19, is substantially aided by directly visualizing the viruses or cellular components responsible for causing disease. The NIH has recently established three National Centers that contain the most powerful microscopes on the planet, enabling biologists across the country to look at these tiny disease-causing components. We will design and build a series of cutting- edge computer programs to help biologists take better pictures, so that we are able to more quickly make biomedically important discoveries.

PI_NAMEs: LANDER, GABRIEL C (contact);STAGG, SCOTT M

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 2019-nCoV;Adoption;Algorithms;application programming interface;Automation;Automobile Driving;base;biological systems;biophysical properties;Buffers;Bypass;Calibration;cluster computing;Code;Communities;comparative;computer infrastructure;computer program;Computer software;computerized data processing;convolutional neural network;Country;COVID-19;Cryoelectron Microscopy;Data;data acquisition;Data Collection;data mining;data quality;Data Set;Databases;design;Development;Disease;Electron Microscope;Electron Microscopy;Electron Microscopy Facility;Electrons;Feedback;fighting;Generations;Goals;Hand;Heterogeneity;Ice;Image;Image Analysis;image processing;improved;innovation;Institution;Intervention;Investments;Learning;Maintenance;Manuals;Methodology;Methods;Microscope;migration;Molecular;Molecular Conformation;neutralizing antibody;next generation;open source;Output;particle;Particle Size;Pathologic;Planets;Play;Plug-in;portability;prediction algorithm;Preparation;preservation;Process;programs;Pythons;real-time images;reconstruction;Research;Resolution;Role;Running;Sampling;Series;Site;Specimen;structural biology;Structure;therapeutic development;Thick;Time;tool;Training;United States National Institutes of Health;Update;Vaccines;Virus;Visualization;Work

PROJECT_TITLE: Automated, optimized, intelligent data collection for cryo-EM

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]