ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis. Intraarticular fractures result in a pro-inflammatory hemarthrosis that may further exacerbate the chondral damage that was sustained due to the original injury. This project will study the effect of joint lavage on the concentration of inflammatory cytokines in the ankle following a high-energy tibial pilon fracture and the resultant effect on short-term patient outcomes.

PI_NAMEs: WHEATLEY, BENJAMIN M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adult;American;Amputation;Animal Model;Ankle;ankle joint;Area;Arthritis;Articular Range of Motion;Blood;Blood flow;Caring;Cartilage;Circulation;Comminuted Fracture type;cytokine;Development;Elbow;Enzyme-Linked Immunosorbent Assay;Exposure to;foot;Fracture;Functional disorder;functional improvement;functional outcomes;Goals;healing;Hemarthrosis;Immobilization;Impairment;Implant;improved;Infection;Inflammation;Inflammatory;inflammatory milieu;Injury;Intervention;joint injury;Joints;Knee;Lavage;Mann-Whitney U Test;Matrix Metalloproteinases;Modality;nutrition;Operative Surgical Procedures;Orthopedics;Outcome;Pathogenesis;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Pharmacologic Substance;Postoperative Period;Process;Prognosis;radiological imaging;Randomized;Research;Risk;Risk Reduction;sample fixation;Sampling;Series;Severities;Societies;soft tissue;standard care;standard of care;surgery outcome;Swelling;Synovial Fluid;Techniques;Testing;Time;Traumatic Arthropathy;treatment group;wound

PROJECT_TITLE: Does joint lavage reduce intraarticular inflammation in high-energy tibial pilon fractures?

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Identification of the synaptic loci that control critical periods of enhanced plasticity is required to improve the success of treatments for amblyopia. Here we propose a series of experiment to test a provocative new model in which the initial response to monocular deprivation during the critical period is a rapid, transient and synapse-specific elimination of local L2/3 PyràPV INs synaptic connections. We propose that this early elimination of local L2/3 PyràPV INs excitatory synapses is obligatory for subsequent changes in ocular dominance and spatial acuity induced by monocular deprivation.

PI_NAMEs: KIRKWOOD, ALFREDO ;MURASE, SACHIKO  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;Amblyopia;area striata;Biological Models;cellular targeting;Consensus;Control Locus;critical period;Data;Development;Distal;Dominant-Negative Mutation;Excitatory Synapse;experience;experimental study;Eye;Glutamates;hippocampal pyramidal neuron;improved;in vivo;insight;Interneurons;meter;Modeling;Molecular Genetics;Molecular Target;monocular deprivation;multidisciplinary;Mus;neural;neuronal pentraxin;Neurons;novel;Ocular Dominance;Output;Parvalbumins;permissiveness;Physiological;Physiology;postnatal;predictive modeling;prevent;Pyramidal Cells;receptive field;recruit;Regulation;Research;response;Series;Shapes;Signal Transduction;Stimulus;Structure;success;Synapses;Synaptic plasticity;Testing;tool;Vision;Visual Acuity;Visual Cortex

PROJECT_TITLE: Reversible activation of critical period plasticity in visual cortex


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Since 10.7% of all maternal deaths are due to postpartum hemorrhage, a personalized prediction tool is essential for clinicians. Despite initiatives aimed at improving pregnancy outcomes, the rates of postpartum hemorrhage are still rising in the United States and new strategies to predict and prevent this complication are urgently needed. We propose to utilize machine learning and genetic risk score approaches, which will allow for transparent, accurate and unbiased prediction that would lead to a greatly enhanced ability to identify high risk patients and dramatically improve maternal health.

PI_NAMEs: KOVACHEVA, VESELA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adopted;Algorithms;Architecture;billing data;biobank;black women;Body mass index;Cessation of life;Clinical;clinical practice;clinical predictors;clinical risk;collaborative environment;Complex;Complication;computerized tools;Data;Databases;Decision Making;Decision Trees;demographics;Electronic Health Record;epidemiology study;evidence base;explainable machine learning;Genetic;Genetic Risk;genetic risk factor;genome wide association study;genomic locus;Genotype;Gestational Diabetes;Goals;Hemorrhage;high risk;Hospitals;Hour;Hypertension;improved;Individual;innovation;Investigation;Laboratories;Link;Logistic Regressions;Machine Learning;machine learning method;machine learning model;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;maternal safety;medical schools;Mentors;Methods;Modeling;multi-ethnic;Nature;neural network;novel;Obesity;obstetric outcomes;Outcome;patient stratification;Patients;Performance;personalized predictions;Pharmaceutical Preparations;Physicians;polygenic risk score;Postpartum Hemorrhage;prediction algorithm;predictive modeling;predictive tools;Predictive Value;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;prevent;Process;Prolonged labor;Publishing;racial bias;racial disparity;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Scientist;severe maternal morbidity;skills;Specific qualifier value;standard of care;tool;trait;translational research program;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Personalized Postpartum Hemorrhage Prediction Using Machine Learning And Polygenic Risk Scores

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Embryonic stem cells (ESCs) form the basis for transformative cell therapies for retinal blindness, which affects over 300M worldwide. Yet the time-dependent mechanisms by which ubiquitous chromatin modifiers and embryonic transcription factors (TFs) interact to direct ESC retinogenesis remain unknown: the proposed research focuses on how the chromatin regulator WDR5 interacts with p53 and MAX, broadly expressed TFs, to control retinal development. Successful completion of the research will advance key concepts related to birth defects of the retina in p53-associated syndromes, current clinical trials that transplant p53 mutant ESC-derived retinal cells in individuals with macular degeneration, and potential off-target effects of WDR5 inhibitors, which are currently in therapeutic development through a $1 billion effort.

PI_NAMEs: RAO, RAJESH C. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;Apoptosis;Award;Binding;Blindness;Cell Fate Control;Cell Therapy;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Congenital Abnormality;CRISPR/Cas technology;Data;Deposition;derepression;Development;Doxycycline;Ectoderm;Embryo;Embryoid bodies;embryonic stem cell;Epiblast;ES Cell Line;Event;Flow Cytometry;gene repression;Genes;Genetic Transcription;Germ Cells;Glean;Guide RNA;Histone H3;histone modification;Immunofluorescence Immunologic;in vivo;Individual;inhibitor;innovation;insight;Intervention;Knowledge;Leucine Zippers;loss of function;Lysine;Macular degeneration;Maps;Medical;Meiosis;Mental Depression;Mesoderm;Mesoderm Cell;Methylation;Molecular;Mouse Embryonic Stem Cells;mutant;Neuroectoderm;Nuclear;Organoids;outcome prediction;Pathway interactions;Phenotype;Population;Proliferating;Proteins;recruit;Repression;Research;Retina;Retinal Defect;retinal progenitor cell;retinogenesis;Role;single-cell RNA sequencing;Source;Specific qualifier value;Structure of primordial sex cell;Syndrome;Technology;Testing;therapeutic development;Therapeutic Effect;Therapy trial;Time;TP53 gene;TP73 Protein;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomic profiling;translational impact;Transplantation;trophoblast;tumorigenesis;Up-Regulation;Visual Fields

PROJECT_TITLE: Molecular Determinants for WDR5-Driven Transcriptional Regulation at Lineage-Specifying Genes During Retinogenesis

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative This application requests Phase II support for a successful COBRE in Mesenchymal and Neural Regulation of Metabolic Networks. Three new diverse projects study thermogenic adipocytes, gut-bone interactions, and impact of night shift work on diabetes risk in pregnancy, and they will contribute to our knowledge about how to better treat chronic metabolic diseases. Core facilities provide support for Physiology, Histopathology and Microscopy, and Proteomics and Lipidomics.

PI_NAMEs: LIAW, LUCY  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Achievement;acute care;Adipocytes;Adipose tissue;Advisory Committees;Area;arm;Award;bariatric surgery;base;Basic Science;Biochemical Pathway;Biology;Biomedical Research;bone;bone loss;Bone Marrow;Cardiovascular system;career development;Career Mobility;Caregivers;Caring;Centers of Research Excellence;Chronic;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Complement;Core Facility;Country;Data Analyses;Data Analytics;Development;Diabetes Mellitus;diabetes risk;Disease;diversity and inclusion;Doctor of Philosophy;doctoral student;Education;Equipment;equity, diversity, and inclusion;Experimental Designs;Faculty;Faculty Recruitment;Feedback;Fellowship;Fostering;Foundations;Funding;Goals;Grant;Growth;Health;Healthcare;Histopathology;Hospitals;improved;Infrastructure;Institution;instrumentation;interest;Investments;Knowledge;Lead;Leadership;lipidomics;Maine;Medical center;member;Mentors;Mentorship;Mesenchymal;Metabolic;Metabolic Diseases;Metabolism;Microscopy;Mission;model development;Modeling;Morbidity - disease rate;mortality;neural;neuroregulation;New England;Obesity;Osteoporosis;Pain;Patient Care;Performance;pharmacologic;Phase;Physiology;Pilot Projects;Policies;population health;Population Research;Predisposition;Pregnancy;Pregnant Women;Principal Investigator;Productivity;Professional Education;professor;Program Evaluation;programs;Proteomics;Public Health;recruit;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;rural disparities;Scientist;Sensory;Services;shift work;Signal Transduction;skeletal;Smooth Muscle;student mentoring;Student recruitment;success;synergism;Talents;Technology;Time;Tissues;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Adipocytes;Advisory Committees;Animals;Applications Grants;Area;Back;bariatric surgery;Biochemical Pathway;bone;Budgets;career development;Career Mobility;Centers of Research Excellence;Chronic;Clinical;Clinical Research;Collaborations;Communication;Communication Programs;Communities;Compensation;Consultations;Core Facility;Creativeness;Data;Data Analyses;Dedications;design;Development;Diabetes Mellitus;diabetes risk;Disease;diversity and inclusion;Doctor of Philosophy;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Feedback;follow-up;Fostering;Funding;Generations;Goals;Grant;Growth;Health;Histopathology;Human;Human Resources;human subject;improved;Individual;Infrastructure;innovation;Institution;instrumentation;Investments;Leadership;lipidomics;meeting reports;meetings;member;Mentors;Mentorship;Mesenchymal;Metabolic;Metabolism;Microscopy;Modeling;Monitor;neuroregulation;New England;new technology;Office of Administrative Management;operation;Performance;Phase;Physiology;Pilot Projects;Policies;Pregnant Women;Process;Productivity;Program Development;Program Evaluation;programs;Progress Reports;Proteomics;recruit;Report (document);Reporting;Research;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Running;Schedule;Scholars Program;Series;Services;shift work;student mentoring;Student recruitment;success;Surveys;Technology;tool;Training;Translational Research;United States National Institutes of Health;Update;Vertebral column;Vertebrates;Work

PROJECT_TITLE: Administrative and Professional Development Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dietary Supplements;Microbiome;Nutrition

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our proposal is relevant to human health as we aim to understand the mechanism how diet impacts the bacteriophage-microbe interactions, which we will exploit to promote colonization of a probiotic, and to deliver therapeutic proteins to ameliorate diet-induced fatty liver disease.

PI_NAMEs: VAN PIJKEREN, JAN-PETER  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TITLE: Mechanism and application of sugar-induced phage production by the probiotic gut symbiont Lactobacillus reuteri

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE The lateral hypothalamus (LHA) orchestrates fundamental behaviors such as arousal, stress and reward, and disruption of neural circuits in this region is associated with disorders of sleep, feeding and motivated behavior, which profoundly affect our physiological well-being and mental health. This proposal will use new and informative cellular and behavioral techniques to dissect the circuits and signaling pathways through which specific LHA neurons shape physiology and behavior. In so doing, we hope to identify targets for therapeutic intervention in treating and improving the quality of life of patients suffering from neuropsychiatric illnesses, addiction, post-traumatic stress disorder, sleep and metabolic disorders.

PI_NAMEs: JACKSON, ALEXANDER CHOI (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Ablation;addiction;Address;Affect;Amygdaloid structure;Anatomy;Animals;Arousal;Axon;Behavior;Behavior assessment;Behavioral;behavioral study;Biological;Brain;cell type;Clinical;Data;differential expression;Dimensions;Disease;Dissection;Dissociation;Electrophysiology (science);Environment;Exhibits;experimental study;fast-acting neurotransmitter;feeding;Feeding behaviors;Foundations;gamma-Aminobutyric Acid;Generations;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Grant;Hypothalamic structure;improved;In Vitro;in vivo;inhibitory neuron;Investigation;Knowledge;Lateral;Lateral Hypothalamic Area;Link;Literature;melanin-concentrating hormone;Memory;Mental Health;Metabolic Diseases;Methods;Molecular;motivated behavior;Mus;Negative Valence;neural;neural circuit;neurochemistry;Neurokinin B;Neuromedin K Receptor;neuronal circuitry;Neurons;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;neuroregulation;neurotransmission;neurotransmitter release;novel;optogenetics;Output;Patients;Peripheral;Personal Satisfaction;Physiological;Physiology;Population;Population Heterogeneity;Positioning Attribute;Positive Valence;Post-Traumatic Stress Disorders;Property;Quality of life;Receptor Signaling;response;Rewards;Shapes;Signal Pathway;Signal Transduction;Sleep;sleep behavior;Sleep Disorders;Source;Stress;Structure;System;Tachykinin;targeted treatment;Taxonomy;Techniques;Therapeutic Intervention;therapeutic target;tool;transcriptomics;transmission process;Viral;Work

PROJECT_TITLE: Inhibitory Cell Types and Circuits in the Lateral Hypothalamus

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Physical Activity

PI_NAMEs: ROSEN, CLIFFORD JAMES (contact)

PROJECT_TERMS: 3-Dimensional;Address;Age;Animal Model;Animals;anti-cancer research;Applications Grants;Award;Behavior;behavioral phenotyping;behavioral study;Biochemical Pathway;Bioenergetics;Body Composition;Body Temperature;Body Weight;Cell Physiology;Cells;Cellular Metabolic Process;Centers of Research Excellence;clinical investigation;cold temperature;Communication;Consultations;Controlled Environment;Cost Analysis;Counseling;Coupled;cytate;Data;Data Analyses;Data Set;Digital X-Ray;Dual-Energy X-Ray Absorptiometry;Education;Energy Metabolism;Equipment;Exercise;Experimental Designs;experimental study;Faculty;Fee-for-Service Plans;flexibility;Food;food consumption;Funding;Future;gas analyzer;Generations;Genus Hippocampus;Glycolysis;Goals;graduate student;Grant;Heart Rate;human disease;human model;Human Resources;Image;imager;In Vitro;in vivo;Incubators;insight;Institution;Leadership;Martes zibellina;Measures;medical schools;meetings;Mesenchymal;Metabolic;metabolic abnormality assessment;metabolic phenotype;Mitochondria;Modeling;mouse model;Mus;mutant;Nature;neuroregulation;New England;new technology;novel;Output;oxidation;Phase;Physical activity;Physiological;Physiology;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Publications;Quality Control;Reader;Reporting;Research;Research Design;Research Institute;Research Personnel;research study;Resources;Respiration;response;Roentgen Rays;service utilization;Services;sex;Site;spheroids;Spirometry;Structure;success;Suggestion;System;Technology;Telemetry;Temperature;Time;tissue culture;Tissues;Training;training opportunity;treadmill;undergraduate student;Universities;Water consumption

PROJECT_TITLE: Physiology Core


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Impaired regulation of blood flow is linked to primary open angle glaucoma, a major cause of blindness worldwide. The goal of this project is to directly measure blood flow in the smallest blood vessels of the eye to identify precise and robust biomarkers for detecting early disease. This would allow for earlier intervention to reverse vision loss, provide future direction for developing new treatments, and aid in monitoring progression of disease.

PI_NAMEs: SAEEDI, OSAMAH JAWAID (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: adaptive optics;adaptive optics scanning laser ophthalmoscopy;Advanced Development;Affect;Age;Air;Angiography;Area;arteriole;Attenuated;Axon;Biological Markers;Blindness;Blood;Blood capillaries;Blood flow;blood flow measurement;Blood Vessels;Caliber;Cell Density;Clinical;comparison control;Data;density;Development;Devices;Disease;Disease Progression;early detection biomarkers;Early Intervention;Erythrocytes;Exhibits;experimental study;Eye;eye blood vessel;Flowmetry;Future;Ganglion Cell Layer;Glaucoma;Goals;Homeostasis;Human;human subject;Hyperoxia;imaging modality;Imaging technology;Impairment;in vivo;Knowledge;Link;Measurable;Measurement;Measures;Mediating;Metabolic;Methods;Modality;Monitor;multimodality;neurovascular;novel therapeutics;Optic Nerve;Optical Coherence Tomography;Oxygen;Pathogenesis;Patients;Perfusion;Physiologic Intraocular Pressure;pressure;Primary Open Angle Glaucoma;programs;Regulation;Reproducibility;Research;Resistance;Resolution;response;Retina;retinal damage;Retinal Ganglion Cells;retinal nerve fiber layer;Sample Size;Site;Techniques;Technology;Testing;Thick;Thinness;Tissues;Vascular Diseases;vascular factor;Vascular remodeling;Venous;Visualization;Work

PROJECT_TITLE: Direct Measures of Retinal Blood Flow and Autoregulation as Robust Biomarkers for Early Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: The base of the mammalian forebrain is studded with clusters of cholinergic neurons that regulate arousal, environmental awareness, and memory consolidation. Here, we focus on an overlooked cluster of these neurons – the tail of the basal forebrain - that have unusual response properties and may regulate our ability to perceive and learn from environmental sounds. Research on the function of basal forebrain tail neurons could identify new therapeutic avenues for the rehabilitation of sensory disorders and illuminate the connection between hearing abilities, dementia, and neurodegenerative diseases.

PI_NAMEs: POLLEY, DANIEL B. (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acetylcholine;Active Listening;Acute;Amygdaloid structure;Animals;antagonist;Arousal;Association Learning;Auditory;Auditory area;auditory nuclei;Auditory Perception;auditory stimulus;aversive conditioning;awake;Award;Awareness;Axon;basal forebrain;basal forebrain cholinergic neurons;Basal Nucleus of Meynert;base;Behavior;Behavioral;Brain;Calcium;Cell Nucleus;cell type;cholinergic;cholinergic neuron;Cholinergic Receptors;Code;conditioning;Corpus striatum structure;Coupling;Dementia;Desire for food;Detection;Diagonal Band Nucleus;Equilibrium;Failure;Fiber;Genetic;Hearing;Hippocampus;Image;indexing;Learning;Measures;Medial;Medial geniculate body;Mediating;Memory;memory consolidation;Modality;Modeling;Monitor;Mus;Neocortex;neural;Neurodegenerative Disorders;Neurons;novel strategies;novel therapeutics;Operant Conditioning;optogenetics;Output;permissiveness;Phase;Preparation;Presynaptic Terminals;Property;Prosencephalon;Psychological reinforcement;Publishing;Pupil;receptive field;Rehabilitation therapy;Reporting;Research;response;Role;sensor;Sensory;Sensory Disorders;Slice;sound;Stimulus;Synaptic plasticity;Tail;Testing;Thalamic structure;Transgenic Mice;two-photon;Whole-Cell Recordings;Work

PROJECT_TITLE: Corticofugal Circuits for Active Listening

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative    The goal of this Wellstone Muscular Dystrophy Specialized Research Center is to identify emerging therapeutic  targets  and  therapeutics,  as  well  as  to  develop  imaging  tools  to  monitor  the efficacy  of  therapies,  that  control  inflammation, fibrosis, and disease progression in a number of muscular dystrophies. We also are focused on  understanding the mechanisms and unwanted side effects of current therapies (e.g. corticosteroids) in order to  improve upon their efficacy and use. With the dawn of gene therapy for Duchenne muscular dystrophy, we feel  it is imperative to understand the deficiencies of the emerging treatments in order to improve upon them before  the deficiencies become evident in patients.

PI_NAMEs: SWEENEY, H LEE (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Animals;Anti-Inflammatory Agents;Biological Markers;biomarker development;Blood;boys;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cell Respiration;Cells;Clinical;Clinical Data;clinical translation;Clinical Trials Network;cohort;Combined Modality Therapy;Communities;Complement;Complex;Data;Development;Disease;Disease Progression;Dose;Duchenne muscular dystrophy;Dystrophin;Effectiveness;Fibrosis;Foundations;Functional disorder;Funding;Future;gene therapy;Genes;Glucocorticoids;Goals;Heart;Human;Image;Imaging Device;imaging modality;Immune;improved;Inflammation;Inflammatory;Inflammatory Infiltrate;Length;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;mdx mouse;Mechanics;Membrane;Metabolic;Metabolism;micro-dystrophin;Mitochondria;Modality;Modeling;Monitor;mouse model;Mus;Muscle;Muscle function;muscle metabolism;muscle regeneration;muscle repair;Muscular Dystrophies;muscular dystrophy mouse model;Myocardium;Natural History;novel;outreach;Pathology;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Physiological;Positioning Attribute;pre-clinical;Process;Regulation;Research;Resources;Scheme;Services;side effect;Site;Skeletal Muscle;skeletal preservation;small molecule therapeutics;Source;Spectrum Analysis;standard of care;Steroids;success;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapy development;Training;Training and Education;transmission process;Treatment Efficacy

PROJECT_TITLE: Understanding and Improving Therapies for the Muscular Dystrophies


NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

PROJECT_TERMS: Advisory Committees;Advocacy;Advocate;Awareness;Clinical;Communication;Communities;Community Outreach;Educational workshop;Family;Funding;improved;International;Leadership;meetings;member;Mission;Muscular Dystrophies;Online Systems;outreach;patient advocacy group;patient outreach;Patients;Persons;programs;Research;Research Personnel;Resource Sharing;Resources;Services;Site;training opportunity;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Core A - Admin Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Hepatitis;Infectious Diseases;Liver Disease

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative: The study of animal viruses has been critical for understanding basic disease mechanisms, including the origin and pathogenesis of related human viruses. In this career development proposal, Dr. Jager will use a novel hepatotropic equine parvovirus to study the role of the DNA damage response pathways in viral genome replication and the impact of exogenous DNA damage on viral hepatitis. These findings will have broad implications on the fundamental mechanisms of viral DNA replication and the synergy between toxins and hepatotropic viruses in humans and animals.

PI_NAMEs: JAGER, MASON CAMERON (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Animals;Award;Biological Assay;career;career development;Cell Culture System;Cell Culture Techniques;Cell Cycle;Cell Proliferation;Cell Survival;Cell-Mediated Cytolysis;Cells;Cellular biology;Child;Clinical;Confocal Microscopy;Data;Dependence;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Viruses;DNA-Directed DNA Polymerase;Enzymes;Epithelial Cells;Equus caballus;experience;Family;Foundations;Funding;G0 Phase;Genome;Goals;Grant;hepatic necrosis;Hepatitis;Hepatocyte;Hepatotoxicity;hepatotoxin;High Prevalence;Human;Human Parvovirus B19;Human Viral Hepatitis;immunocytochemistry;Immunofluorescence Immunologic;improved;In Situ;In Situ Hybridization;In Vitro;in vivo;Individual;Infection;Interphase Cell;K-Series Research Career Programs;Label;Lentivirus Vector;Ligation;Liver;Liver diseases;liver infection;Mentors;Molecular;Molecular Virology;Names;novel;Outcome;Parvovirus;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phosphorylation;Polymerase;programs;Protein Kinase;Pyrrolizidine Alkaloids;Qualifying;Research;Respiratory Disease;response;Role;Sampling;Scientist;Severities;Signal Transduction;skills;small hairpin RNA;small molecule inhibitor;Source;spheroids;synergism;Tissue Sample;tool;Topoisomerase Inhibitors;Toxicology;Toxin;Training;transcriptomics;Tropism;Ultraviolet Rays;viral DNA;Viral Genome;Viral hepatitis;Viral Pathogenesis;Virus;Virus Replication;Western Blotting

PROJECT_TITLE: Mechanisms of parvovirus replication in viral hepatitis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: LINDNER, VOLKHARD  (contact)

PROJECT_TERMS: 3-Dimensional;Adipocytes;Adipose tissue;Antibodies;Antigens;Automation;Biochemical;Biochemical Pathway;Biological;Biology;Blood Vessels;Bone Tissue;Cell Culture Techniques;Cells;Centers of Research Excellence;Charge;Client;Clinical;Communities;Confocal Microscopy;Consultations;Core Facility;cost;Custom;Dedications;detection method;Equipment;experience;Fluorescence Resonance Energy Transfer;Freezing;Funding;Funding Mechanisms;Goals;Grant;Hazardous Waste;histological stains;Histology;Histopathology;Histopathology Facility;Image;Immunohistochemistry;improved;instrumentation;Investments;Laboratories;Maine;Manuals;Medical center;medical specialties;member;Mesenchymal;Microscope;Microscopy;mineralization;Monoclonal Antibodies;morphometry;National Institute of General Medical Sciences;neuroregulation;New England;operation;Outcome;Paraffin Embedding;Pathology;Phase;Physicians;Physiology;Plastic Embedding;polyclonal antibody;Postdoctoral Fellow;Price;Procedures;Production;Protein translocation;Proteins;Publications;Research;Research Personnel;Resource Sharing;Resources;Retrieval;Running;sample fixation;Scientist;Services;Sister;skeletal;Solvents;SP1 gene;Specimen Handling;stem;stem cell biology;success;Technical Expertise;Techniques;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Stains;Tissues;Training;United States National Institutes of Health;Universities;Validation;Workload

PROJECT_TITLE: Histopathology and Microscopy Core


PI_NAMEs: JUDGE, ANDREW ROBERT (contact)

PROJECT_TERMS: Academia;Advocacy;Area;Basic Science;Biology;Biotechnology;California;career;career development;Cellular biology;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Communities;Conduct Clinical Trials;Critiques;Data;data sharing;design;Development Plans;disability;Disease;diversity and inclusion;doctoral student;Drug Industry;Education;Enrollment;Environment;Ethnic Origin;Event;experience;Faculty;faculty mentor;Funding;Gender;Goals;Grant;Growth;Health;improved;Individual;Industry;industry partner;Infrastructure;innovation;Institution;interest;International;Investments;Laboratory Research;Leadership;member;Mentors;minority scientist;Muscle;Muscle Cells;Muscular Dystrophies;Myopathy;next generation;Outcome Measure;Phase;Physicians;Physiological;Postdoctoral Fellow;pre-clinical;pre-doctoral;Productivity;Program Evaluation;programs;Qualifying;Race;Recommendation;Records;recruit;Research;Research Personnel;Research Support;responsible research conduct;Scientist;Site;Skeletal Muscle;skills;Socioeconomic Status;stem;Structure;Students;success;symposium;System;Teacher Professional Development;Testing;Time;Training;Training Activity;Training and Education;Training Programs;translational approach;Translational Research;Travel;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;web site;Writing

PROJECT_TITLE: Core B - Training Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Obesity

PI_NAMEs: VARY, CALVIN PARDEE HULL (contact)

PROJECT_TERMS: Address;Adipocytes;Applications Grants;Award;bariatric surgery;Basic Science;Biochemical Pathway;Biological;Biomedical Engineering;bone loss;Bone remodeling;Cardiometabolic Disease;Cardiovascular system;Cells;Centers of Research Excellence;Client;Clinical Research;Complex;Core Facility;Data;data acquisition;Data Analyses;Data Collection;data integration;data repository;Development;Doctor of Philosophy;energy balance;Ensure;Equipment;equipment acquisition;experience;Experimental Designs;facility renovation;flexibility;Funding;Future;Goals;Grant;Human;human tissue;improved;Informatics;innovation;insight;Institution;instrument;instrumentation;Investments;Ions;Isotopes;large datasets;lipidome;lipidomics;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Mass Chromatography;mass spectrometer;Mass Spectrum Analysis;Mesenchymal;Metabolic;Methodology;modifiable risk;Molecular;Monitor;multiple reaction monitoring;Mus;National Institute of General Medical Sciences;neuroregulation;novel;novel strategies;Outcome;Peptides;Phase;Physiological;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Preparation;programs;Property;Protein Analysis;protein expression;Proteins;Proteome;Proteomics;Protocols documentation;Publishing;Reaction;recruit;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk Factors;Role;Sampling;Scanning;Scientific Inquiry;Serum;Services;Signal Transduction;Specimen;Statistical Data Interpretation;Statistical Methods;Students;success;Technology;Tissue Engineering;Tissue Sample;Tissues;Training;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Proteomics and Lipidomics Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Social connectedness is a promising pathway to slowing the progression of Alzheimer’s disease (AD). The current project will advance our understanding of why social connectedness confers resilience by leveraging existing infrastructure, a multi-method approach, and an interdisciplinary research team. By increasing our understanding of the links between biological and social processes, this project may help identify novel targets for intervention to reduce the burden of AD on individuals, families, and the health care system.

PI_NAMEs: KRENDL, ANNE CATHERINE (contact);PERRY, BREA LOUISE

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Acquaintances;Affect;age related;age-related disease;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Biological Process;Brain;Brain region;burden of illness;Characteristics;Clinical;Cognitive;cognitive ability;Cognitive aging;Cognitive deficits;cognitive function;cognitive performance;cohort;Complex;Dementia;Exercise;Face;Family;Family member;Friends;Functional Magnetic Resonance Imaging;Funding;Goals;Health;Healthcare Systems;Impaired cognition;improved;Individual;Infrastructure;innovation;insight;Interdisciplinary Study;Intervention;Interview;Knowledge;life span;lifestyle intervention;Link;longitudinal design;Measures;Mediating;member;Memory;mental state;Meta-Analysis;Methods;mild cognitive impairment;neurobiological mechanism;Neurocognitive;neuroimaging;novel;older adult;Participant;Pathway interactions;Peripheral;Persons;Prevalence;Process;Public Health;recruit;Reproducibility;Research;Research Personnel;resilience;Resources;response;Rest;Role;Science;Site;social;social cognition;social engagement;social implication;Social Interaction;social interventions;Social Network;social neuroscience;Social Processes;social relationships;sociodemographic variables;Structure;Taxes;Testing;theory of mind;Time;Work

PROJECT_TITLE: Understanding how social connectedness protects older adults' cognitive health: the role of social cognition


NIH_SPENDING_CATS: Aging;Behavioral and Social Science

ORG_CITY: NEW YORK

ORG_NAME: AMERICAN GERIATRICS SOCIETY

PHR: PROJECT NARRATIVE The population of older adults in the United States is expanding as is the understanding of the basic biology that underlies the many clinical changes that happen to older people. The overall focus of this proposal is to support efforts to continue the successful “Geriatrics Research: Bench-to-Bedside” conference series, focusing on elucidating of phenomena of resilience with aging and its multi-component dimensions in response to physical, cognitive, and social stressors. This series encompasses sharing of knowledge, exchanging new ideas,education, mentorship and exploring recent developments as well as defining knowledge gaps and priority future research directions.

PI_NAMEs: ABADIR, PETER M. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adherence;age related;age related chronic disease;age related decline;Aging;aging process;American;Area;bench to bedside;Biology;Biology of Aging;Clinical;clinical care;Clinical Research;Cognitive;Collaborations;Communication;Communities;comorbidity;Delirium;Development;Dimensions;Disease;Education;Elderly;Faculty;Fostering;Foundations;frailty;Geriatrics;Geroscience;Goals;Grant;Health;improved;Inflammation;interest;Interest Group;Intervention;Journals;Knowledge;Leadership;Learning;Measurement;Medical Students;meetings;member;Mentorship;Minority;Minority Participation;Mission;molecular marker;multidisciplinary;multiple chronic conditions;National Institute on Aging;Nature;nutrition;older adult;Older Population;Organism;Outcome;Physicians;Process;promote resilience;psychosocial;Publications;Research;research and development;Research Personnel;resilience;resilience biomarker;resilience research;response;Science;Scientist;Series;social;social stressor;Societies;Stress;stress resilience;Stress Tests;stressor;Structure;symposium;Syndrome;Time;timeline;Training;Translating;Translations;United States;United States National Institutes of Health

PROJECT_TITLE: Geriatrics Research: From Bench-to-Bedside

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Genetics;Nutrition;Obesity

PI_NAMEs: LYNES, MATTHEW D (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Amino Acids;Animals;Biochemical Pathway;Bioenergetics;Birth;Blood Vessels;Brown Fat;Cardiovascular Diseases;Cations;Cell Lineage;Cell Physiology;cell type;Cells;Centers of Research Excellence;Clustered Regularly Interspaced Short Palindromic Repeats;cold temperature;Confocal Microscopy;Coupled;Development;differential expression;Disease;Doctor of Philosophy;Drug usage;Dyslipidemias;Energy Intake;Energy Metabolism;Exposure to;Fatty acid glycerol esters;Fibrates;Frequencies;Functional disorder;Genes;Genetic;glucose disposal;glucose metabolism;Health;High temperature of physical object;Histopathology;Human;Hyperlipidemia;Immunohistochemistry;Impairment;improved;in vivo;Individual;innovation;insulin sensitivity;Kidney Failure;Label;Lead;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;loss of function;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Medical;member;Mentors;Mesenchymal;Messenger RNA;Metabolic;Metabolic syndrome;Metabolism;Microscopy;Modeling;mouse genetics;mouse model;Mus;neuroregulation;non-alcoholic fatty liver;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Oxidative Phosphorylation;Pathway interactions;Peptides;Phase;Phenotype;Physiology;Platelet-Derived Growth Factor alpha Receptor;PPAR alpha;progenitor;protein profiling;Proteins;Proteome;proteomic signature;Proteomics;Public Health;receptor;recruit;Regulation;Research Personnel;Risk;Role;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Stains;stem cells;Temperature;Testing;Thermogenesis;tissue processing;Translating;translational impact;Triglyceride Metabolism;Triglycerides;uncoupling protein 1;Vascular Smooth Muscle

PROJECT_TITLE: Genetics regulators of vascular smooth muscle thermogenic differentiation


PI_NAMEs: BARTON, ELISABETH R (contact)

PROJECT_TERMS: Age;Animals;Biological Assay;Blinded;Body Composition;Breeding;Cell Therapy;Collaborations;Communities;Complement;Data;Dystrophin;Equipment;Evaluation;experience;experimental study;Florida;gene therapy;Goals;Hindlimb Suspension;Histology;House mice;Human Resources;improved;In Situ;in vivo;Individual;Injury;instrumentation;Laboratories;Letters;Liquid substance;Measurement;Measures;Mechanics;member;Modeling;mouse model;Mus;Muscle;Muscle function;Muscular Dystrophies;muscular dystrophy mouse model;Nitrogen;Nuclear Magnetic Resonance;Outcome Measure;pharmacologic;Physiological;Plethysmography;Preparation;Rattus;Rehabilitation therapy;Research;Research Design;Research Personnel;Resources;Respiratory Center;Respiratory Diaphragm;Respiratory physiology;Running;Sampling;Services;sex as a biological variable;skills;Soleus Muscle;Testing;Therapeutic;tibialis anterior muscle;Time;treadmill;Universities

PROJECT_TITLE: Core C - Resource Core


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Hematology;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Poor recovery from orthopaedic injury, including severe pain and impaired bone healing, affects millions of Americans. Myeloid-lineage cells (peripheral macrophages and spinal cord microglia) are mobilized to resolve tissue damage, however, persistent activation of these cells can be detrimental by contributing to pain and delayed healing. This work aims to develop approaches to monitor dysfunctional myeloid-lineage cells and modulate specific targets for novel therapeutics that will improve post-injury recovery.

PI_NAMEs: TAWFIK, VIVIANNE L (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute Pain;Affect;Affective;American;attenuation;bone fracture repair;bone healing;bone imaging;Cell Lineage;Cells;cellular targeting;chronic pain;Clinical;Complex;critical period;cytokine;Etiology;Functional disorder;Functional impairment;genetic manipulation;glial activation;healing;Human;immune activation;Immune system;Impaired healing;Impairment;improved;improved outcome;in vivo monitoring;Individual;Infiltration;Injury;injury recovery;Innate Immune Response;Intervention;Knowledge;Ligands;Link;Long term disability;Macrophage;Microglia;Molecular;Molecular Profiling;Molecular Target;Monitor;Motivation;mouse model;Myelogenous;new therapeutic target;novel marker;Operative Surgical Procedures;Orthopedics;Pain;Perioperative;Peripheral;Persistent pain;Persons;Positioning Attribute;Positron-Emission Tomography;Recovery;Research;response;response to injury;Risk;serial imaging;Spinal Cord;Surgical Injuries;Tissues;Transgenic Organisms;Trauma;Traumatic injury;Whole Organism;Work;Yolk Sac

PROJECT_TITLE: Myeloid lineage targeting to improve recovery from injury and surgery: Cellular and molecular mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Nutrition;Obesity;Osteoporosis;Prevention

PI_NAMEs: LI, ZIRU  (contact)

PROJECT_TERMS: Ablation;Adipose tissue;Adult;Affect;Anatomy;Automobile Driving;bariatric surgery;Biochemical Pathway;Body Composition;Body Weight;Body Weight decreased;bone;bone cell;Bone Density;bone loss;Bone Marrow;Bone Marrow Cells;bone mass;bone metabolism;Bone remodeling;Breeding;Cardiovascular Diseases;Cell Separation;Cells;Cellular Metabolic Process;Centers of Research Excellence;Clinical Management;Consumption;Data;design;Dietary Calcium;Diphtheria Toxin;Doctor of Philosophy;Endocrine;Endocrine Glands;Energy Metabolism;Excision;Exercise;Fatty Liver;Food;Fracture;fracture risk;FRAP1 gene;Gastrectomy;Gastric Glands;gastric secretion substance;Gastrins;ghrelin;glucose metabolism;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;high risk;Histamine;Histologic;Histopathology;Homeostasis;Hormones;Human;improved;In Vitro;in vivo Model;Inflammatory;insight;Lead;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Malignant Neoplasms;Malnutrition;Marrow;Mechanics;Mediating;Mentors;Mesenchymal;microbiota;Microscopy;Modeling;Molecular Analysis;Monitor;Morbid Obesity;Mus;Myelogenous;Myeloid Cells;neglect;neuroregulation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;Obesity;Operative Surgical Procedures;osteoclastogenesis;Osteogenesis;osteogenic;pandemic disease;Patients;Phase;Phenotype;Physiology;Population;prevent;Preventive;Procedures;protective effect;protein profiling;Proteins;Proteomics;Regulation;Reporter;Research;Research Personnel;Risk;Rodent;Secondary to;Services;side effect;Signal Transduction;Site;skeletal;Skeleton;Somatostatin;Source;Stomach;Testing;Therapeutic;Tissues;transcriptomics;Vitamin D;Weight-Bearing state

PROJECT_TITLE: Gut regulation of bariatric surgery-induced bone loss


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Prevention;Rare Diseases

PROJECT_TERMS: Address;adenovirus mediated delivery;Anti-Inflammatory Agents;antifibrotic treatment;Attention;Calcium;Cardiac;cardiac muscle disease;Cardiomyopathies;clinical implementation;Clinical Trials;Combined Modality Therapy;Compensation;Complex;Defect;design;Development;Disease;Disease Progression;Dose;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;Evaluation;Extracellular Matrix;Extravasation;Fibrosis;Functional disorder;gene therapy;Heart;heart function;Immune response;improved;Inflammation;Inflammatory;inhibitor;Ion Channel;Life;Limb structure;Maintenance;mdx mouse;Membrane;mitochondrial dysfunction;Modeling;Muscle;Muscle function;Muscular Dystrophies;Myocardium;Myopathy;Neuromuscular Junction;older patient;overexpression;Pathology;Patients;Pharmaceutical Preparations;prevent;Prevention;Process;Respiratory Diaphragm;scaffold;Skeletal Muscle;Steroids;Striated Muscles;Testing;Therapeutic;therapeutically effective;Transgenes;transmission process;Utrophin;vector;Viral;viral gene delivery;Viral Load result

PROJECT_TITLE: Potential therapies for the muscular dystrophies


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Adolescent depression and cannabis use are concurrent major public health concerns, and both have been associated with long-term alterations in brain function and behavior. This research training fellowship utilizes non-invasive neuroimaging approaches to examine reward function in the co-occurrence of depression and cannabis use in adolescence, a critical and vulnerable period of brain development. By seeking to understand brain processes underlying these comorbid conditions early in life, this project has the potential to inform future preventive, diagnostic, and therapeutic strategies that may be employed in the care of this high-risk population.

PI_NAMEs: NGUYEN, TRAM NGOC BAO (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 18 year old;Address;Adolescence;Adolescent;Adult;Age;age group;Anhedonia;animal data;Anterior;Anxiety;anxiety symptoms;Area;Behavior;Behavioral;Biological Markers;Brain;Cannabis;Caring;Cause of Death;child depression;Childhood;Chronic;chronic depression;cingulate cortex;Clinical;Clinical Research;Cognitive;cognitive process;comorbidity;Corpus striatum structure;Cross-Sectional Studies;Data;Depressed mood;depressive symptoms;design;Development;Diagnostic;Dimensions;Enrollment;Ensure;epidemiologic data;Evaluation;Exclusion;experience;Fellowship;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Future;high risk population;illicit drug use;Laboratories;Life;Maintenance;marijuana use;marijuana user;Measures;Mental Depression;Mental disorders;Mentorship;mood symptom;neural;neural circuit;neuroimaging;neuromechanism;Neuronal Plasticity;Outcome;Participant;Patient Self-Report;Pattern;Perception;Pharmaceutical Preparations;phenomenological models;Physicians;Population;Positioning Attribute;Prefrontal Cortex;Preventive;Procedures;Process;programs;Psychopathology;Psychosocial Factor;psychosocial stressors;Psychotropic Drugs;Public Health;Research;Research Personnel;Research Training;Rest;reward anticipation;reward circuitry;reward dysfunction;reward processing;Rewards;Scientist;Severities;sex;Stimulus;substance use;suicidal;Suicide;symptomatology;Symptoms;System;Teenagers;Testing;Tetrahydrocannabinol;Therapeutic;therapeutic target;Toxicology;Training;Trauma;Urine;Work;Youth

PROJECT_TITLE: Reward Function in Adolescents with Depression and Cannabis Use


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Sleep Research;Women's Health Research

PI_NAMEs: AGARWAL, ISHA  (contact)

PROJECT_TERMS: Address;Affect;Age;American;awake;Biochemical Pathway;Biological;biological adaptation to stress;Biological Markers;Biometry;career;career development;Centers of Research Excellence;Cesarean section;Chronic Disease;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;Clinical;cohort;Cohort Studies;Complement;Complex;Data;Development;Diabetes Mellitus;early pregnancy;Eating;Epidemic;Epidemiology;epidemiology study;experience;experimental study;Fasting;Fetal Macrosomia;follow-up;Funding;Future;Gestational Age;Gestational Diabetes;Hair;Health;high risk;High Risk Woman;Homeostasis;Hydrocortisone;Hyperglycemia;Hypothalamic structure;IL8 gene;Industry;Inflammation;Inflammatory;Insulin Resistance;Interferon Type II;Interleukin-6;Intervention Studies;Intervention Trial;Lead;Life Style;longitudinal, prospective study;Measurement;Measures;Mediation;Mentors;Mesenchymal;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metabolomics;middle age;modifiable risk;Morbidity - disease rate;mortality;Mothers;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;Nurses' Health Study;Obesity;Occupational;Outcome;Phase;Physicians;Pituitary Gland;Plasma;Play;post pregnancy;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;progression risk;prospective;Prospective Studies;Prospective, cohort study;Public Health;Questionnaires;Recording of previous events;reproductive;reproductive epidemiology;Research;Research Methodology;Research Personnel;Risk;Risk Factors;risk stratification;Role;Scientist;secondary analysis;shift work;Sleep;Sleep disturbances;sociodemographics;Statistical Methods;Stress;Testing;TNF gene;Training;Training Activity;Woman;Work

PROJECT_TITLE: The role of night shift work in metabolic disorders during and after pregnancy


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Parkinson's Disease;Patient Safety;Physical Rehabilitation;Rehabilitation;Social Determinants of Health;Telehealth

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: PROJECT NARRATIVE Airway protective disorders are a prevalent and progressive consequence of Parkinson’s Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical deficits. We will examine the comparative effectiveness of a novel treatment paradigm delivered in-person versus via telehealth in persons with PD, as well as the role of patient burden and treatment adherence on outcomes; thus, the proposed research is relevant to public health and in line with NIH’s mission to identify novel, efficacious, and accessible rehabilitation strategies for short- and long-term improvement of dysfunctional airway protection in PD.

PI_NAMEs: TROCHE, MICHELLE S (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;arm;Aspiration Pneumonia;barrier to care;care burden;Caregiver Burden;Caring;Cause of Death;Cessation of life;Client satisfaction;Clinical;clinical center;Clinical Research;clinical translation;cognitive function;comparative effectiveness;Coughing;Data;Deglutition Disorders;Disease;efficacious intervention;Elderly;Functional disorder;Future;Geographic Locations;Geography;Goals;Health;health care availability;Health Care Costs;health care disparity;Health Insurance;Health Services;Healthcare;Hospitalization;Impaired cognition;Improve Access;improved;Individual;Insurance Coverage;Invaded;Life;Light;Maintenance;Mission;Modality;mortality;muscle strength;Nature;novel;Outcome;Parkinson Disease;Patient-Focused Outcomes;Patients;Peak Expiratory Flow Rate;Persons;Phase;Physiological;poor health outcome;Population;pressure;programs;Public Health;Quality of life;randomized, clinical trials;rehabilitation paradigm;rehabilitation service;rehabilitation strategy;Rehabilitation therapy;Research;respiratory health;response;Role;Service delivery model;Services;Severity of illness;Site;skills training;standard of care;strength training;telehealth;treatment adherence;treatment duration;trial comparing;United States;United States National Institutes of Health;urban area;Work

PROJECT_TITLE: Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-Person and Telehealth Service Delivery Models

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Pediatric;Rare Diseases

PROJECT_TERMS: Affect;Annexin A6;Anti-Inflammatory Agents;Antibodies;arm;Biological Markers;Biological Products;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase II;Cardiomyopathies;Cardiopulmonary;Cell Respiration;cell type;Cells;circulating biomarkers;Clinical Data;Clinical Trials;Collaborations;combinatorial;Core Facility;cytokine;Data;deflazacort;design;Disabling;Disease;Dose;Duchenne muscular dystrophy;DYSF gene;Exercise Tolerance;Experimental Designs;experimental study;Florida;functional improvement;functional outcomes;Funding;GDF8 gene;gene therapy;Genetic;Genetic Variation;Glucocorticoids;Goals;Heart;Human;Human Genetics;Image;Immune;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;insight;latent TGF-beta binding protein;Left ventricular structure;Life;Limb-Girdle Muscular Dystrophies;mdx mouse;Mediating;Mediator;Membrane;Metabolic;Microscopy;Modeling;Monitor;Mononuclear;mouse model;Mus;Muscle;Muscle function;muscle repair;Muscular Dystrophies;muscular dystrophy mouse model;Myocardium;novel;Outcome;overexpression;Oxygen Consumption;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;Phase;Prednisone;prevent;programs;Regimen;repaired;Research Personnel;Resolution;Right ventricular structure;Role;seal;Serum;side effect;Signal Transduction;Skeletal Muscle;small molecule;Steroids;Testing;Time;transcriptome;Translating;Universities;Work

PROJECT_TITLE: Modifying heart and skeletal muscle in muscular dystrophy


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Complementary and Integrative Health;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Persistent Type I IFN signaling is a major driver for chronic inflammation and immune dysfunction during HIV infection. Major components of the cannabis (THC and CBD) may have anti-inflammatory properties but the individual effects and mechanisms of THC and CBD immune regulation remain unknown. In this project, we aim to elucidate the effects and mechanisms of THC and CBD on HIV associated immune cell activation/dysfunction and CNS inflammation, particularly type I IFN mediated inflammation.

PI_NAMEs: KITCHEN, SCOTT G;ZHEN, ANJIE  (contact)

PROJECT_TERMS: Acceleration;Affect;Agonist;Analgesics;Animals;antagonist;Anti-Inflammatory Agents;Anti-viral Response;Antigen-Presenting Cells;Antiinflammatory Effect;antiretroviral therapy;Automobile Driving;Binding;Biological;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;Cannabis sativa plant;Cardiovascular Diseases;cell type;Cells;Central Nervous System;Chronic;chronic inflammatory disease;Clinical Management;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;Combined Modality Therapy;comorbidity;Complex;cytokine;Dendritic Cells;Disease;Disease Progression;dosage;Drug usage;endogenous cannabinoid system;exhaustion;Frequencies;Functional disorder;Gene Expression;Genes;high dimensionality;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;Immune;immune activation;immune function;Immune system;Immune System Diseases;Immunocompetence;immunoregulation;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Interferon alpha;Interferon Type I;Interferons;knock-down;Knock-out;latent HIV reservoir;Macaca mulatta;Macrophage;Malignant Neoplasms;marijuana use;Mediating;Microglia;monocyte;mouse model;Neurodegenerative Disorders;Pathogenesis;Patients;Persons;Plasma;Play;Predisposition;prevent;Property;receptor;Reporting;response;Role;Signal Pathway;Signal Transduction;SIV;small hairpin RNA;Specimen;T cell response;T-Lymphocyte;Tetrahydrocannabinol;THC receptor;United States;Viral;Viral Load result;Virus Replication

PROJECT_TITLE: Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Nutrition;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: WALTER, GLENN  (contact)

PROJECT_TERMS: Age;Animal Model;Becker Muscular Dystrophy;Bioenergetics;Biological Markers;biomarker development;biomarker identification;Body mass index;boys;Calcium;Calpain;Categories;Chronic;Clinical Data;Clinical Management;Clinical Research;Clinical Trials;cohort;Data;Development;Disease;Disease Marker;disease natural history;Disease Progression;Dose;Duchenne muscular dystrophy;Dystrophin;Energy Metabolism;Exposure to;Fatty acid glycerol esters;Future;gene therapy;Glucocorticoids;heart function;Immune response;Impairment;improved;in vivo;Individual;Infiltration;Inflammation;Inflammatory;insight;Limb-Girdle Muscular Dystrophies;Magnetic Resonance;Membrane;Metabolic;metabolic profile;Metabolism;metabolome;metabolomics;micro-dystrophin;Mitochondria;mitochondrial dysfunction;Monitor;Mus;Muscle;muscle metabolism;Muscular Atrophy;Muscular Dystrophies;muscular structure;Mutation;Natural History;Nature;neglect;new therapeutic target;novel;novel marker;Obesity;Participant;patient population;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;Phenotype;Population;pre-clinical;pre-clinical therapy;Proteins;Regimen;repaired;Research Personnel;Respiratory Muscles;restoration;Risk Factors;Serum;Skeletal Muscle;small molecule;Steroids;synergism;targeted biomarker;therapeutic development;Therapeutic Effect;therapeutic target;therapy development;Tissues;treatment strategy;Urine;Work

PROJECT_TITLE: Understanding and Improving Therapies for the Muscular Dystrophies through Noninvasive Biomarkers


ORG_CITY: INDIANAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative The concise and efficient synthesis of complex molecules and their selective functionalization are exceptionally challenging aspects of therapeutic development. This five-year research program is to develop novel single-electron oxidation chemistry of aromatic N-oxides via the enabling technology of photoredox catalysis for 1) the innovation of new vinyl radical synthetic methods via hitherto inaccessible chemical reactivity for the synthesis of molecular complexity and efficient preparation of functional motifs commonly encountered in biologically active compounds; 2) the development of a new and readily tunable platform for site- and stereo-selective functionalization of unactivated C(sp3)–H bonds by catalyst control to enable the selective conversion of abundant petrochemical stocks into high-value chemicals and selective functionalization of complex molecules.

PI_NAMEs: DENG, YONGMING  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Selective Chemical Synthesis and Catalysis Enabled by Single-Electron Oxidation of Aromatic N-oxides


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Statins are the cornerstone in the treatment of coronary heart disease. However, the use of statins has been limited by myopathic side effects. In this proposal, I will employ patient-specific induced pluripotent stem cell- derived skeletal muscle platforms combined with genome-scale CRISPR interference technology. By doing such, the goal will be to discover the genetic determinants of statin induced myopathy and the molecular mechanisms underlying patient-specific differential susceptibilities to statin toxicity. This knowledge should be of significant value to improve prediction of at-risk subjects, optimize statin therapeutic benefit, and identify novel SIM therapeutic targets making precision medicine possible.

PI_NAMEs: RHEE, JUNE-WHA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adherence;Affect;Animal Model;Area;Biochemical;Biological Assay;Biotechnology;Blood;Calcium;Cardiac;Cardiac Myocytes;cardiovascular health;Cardiovascular system;Cell Death;Cell Differentiation process;Cell Line;Cell Membrane Permeability;Cell Respiration;Cells;Cholesterol;Clinic;Clinical;Code;cofactor;Complex;Coronary heart disease;Coupled;CRISPR interference;Diagnosis;diagnostic tool;Disease;Endothelial Cells;Engineering;Evaluation;gene function;gene network;Gene Silencing;Generations;Genes;Genetic Determinism;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;genome wide association study;genome-wide;Genotype;Glucose;Goals;Grant;Guide RNA;Homeostasis;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;Injury;Investigation;knock-down;Knowledge;Lead;Libraries;Life;loss of function;Luciferases;Mediating;Medical;Medicine;Membrane Transport Proteins;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Molecular Target;Monitor;mouse model;Muscle;Muscle Cells;Muscle Fibers;Muscle Weakness;Myalgia;Myopathy;Nicotinamide adenine dinucleotide;novel;novel diagnostics;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathogenesis;patient derived induced pluripotent stem cells;patient subsets;patient tolerability;Patients;Pharmaceutical Preparations;Phenotype;pleiotropism;precision medicine;Predisposition;prevent;Prevention;Protocols documentation;Qi;Reaction;recruit;Reporter;Reporting;Research;Research Personnel;Research Training;Resistance;response;Rhabdomyolysis;Risk;Role;screening;side effect;skeletal;Skeletal Muscle;Stress;Symptoms;Techniques;Technology;Testing;Therapeutic;therapeutic target;tool;Toxic effect;transcriptomics;Treatment Efficacy;United States National Institutes of Health;uptake;Variant

PROJECT_TITLE: Patient-specific modeling of metabolic dysfunction in statin-induced myopathy using iPSC-derived myocytes


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Neurosciences;Nutrition

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE The goal of this project is to discover the neural substrates that link perception and assessment of environment to metabolic and reproductive output. I will leverage the accessibility of the nervous system in Drosophila melanogaster to isolate neurons and signaling molecules that control fly reproduction and metabolism, which may uncover new circuitry linking brain and metabolic state. This work offers the prospect of discovery of pathways which may underly idiopathic metabolic disorders in humans and offer broad biological insights into how animals coordinate metabolism with environment.

PI_NAMEs: MEISELMAN, MATTHEW RAMIAH (contact)

PROGRAM_OFFICER_NAME: SESMA, MICHAEL A

PROJECT_TERMS: Adrenergic beta-Antagonists;Affect;Afferent Neurons;Allatostatin;Amphetamines;Animals;Architecture;Attenuated;Biological;Blood flow;Brain;Calcium;Cardiac Output;career;Cells;Cephalic;cholinergic;circadian;Complex;Cues;Dehydration;Distal;Drosophila genus;Drosophila melanogaster;Drug Targeting;egg;Endocrine;Environment;environmental adaptation;experimental study;Exposure to;Extramural Activities;feeding;Female;fly;Food;Fostering;Funding;gastric secretion substance;Genetic;Goals;Heart;Heart Rate;Hormones;Human;Hunger;Image;insight;Insulin;Investigation;knock-down;Label;Laboratories;Link;Maps;Mentors;Mentorship;Metabolic;Metabolic Control;Metabolic Diseases;metabolic rate;Metabolism;metabolomics;Minority-Serving Institution;Modeling;Molecular;Motility;Nature;Nerve;Nervous System;Nervous System Physiology;neural;neural circuit;Neural Pathways;Neurobiology;Neurons;Neuropeptides;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel;nutrient deprivation;optogenetics;Organism;Output;Oxygen;Partner in relationship;Pathway interactions;Perception;Performance;Pericardial body location;Periodicity;Phase;Polycystic Ovary Syndrome;Population;Postdoctoral Fellow;preservation;Production;programs;Proxy;Reporter;Reproduction;reproductive;reproductive development;reproductive organ;reproductive system disorder;Research;Resolution;Resources;Respiration;response;RNA interference screen;Role;sensory integration;Sexual Arousal;Signaling Molecule;Smell Perception;Specific qualifier value;Spirometry;Starvation;stressor;Structure;Students;success;System;Technical Expertise;Techniques;Temperature;Thirst;Time;Tissues;tool;Vision;Visualization;warm temperature;Work

PROJECT_TITLE: Neural Substrates Controlling Metabolic and Reproductive State


NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Modified Public Health Relevance Section (The narrative contained no specific references to the in vivo mouse experiments and therefore is unchanged): Many proteins are modified by the addition of sugars, or glycosylation, which can alter their function. This proposal is aimed at understanding a specific type of glycosylation, termed O-GlcNAc, that plays important roles in protein aggregation. This work will uncover the specific role of O-GlcNAc on critical proteins in neurodegenerative diseases, a key prerequisite to the potential targeting O-GlcNAc as a therapeutic strategy.

PI_NAMEs: PRATT, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acetylation;Affect;alpha synuclein;Amyloid;amyloid formation;amyloid structure;Animals;Biochemical;Biochemistry;Biological;Biology;biophysical properties;Biophysics;Carbohydrates;Cellular biology;Charcot-Marie-Tooth Disease;Chemicals;Collaborations;Cryoelectron Microscopy;dark matter;Data;Development;Diabetes Mellitus;Diffusion;Disease;Embryonic Development;Excision;experimental study;Functional disorder;Funding;glycosylation;Goals;Grant;Heat shock proteins;HSPB1 gene;human disease;in vivo;Kinetics;Knowledge;Ligation;Malignant Neoplasms;Mammals;Measures;Methods;Michigan;Modification;Molecular;Molecular Chaperones;monomer;Monosaccharides;Mus;Mutagenesis;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Neuropathy;O-GlcNAc transferase;Parkinson Disease;Pathogenicity;Pathway interactions;Patients;Peripheral Nervous System Diseases;Phosphorylation;Play;Point Mutation;Polymorph;Post-Translational Protein Processing;prevent;programs;protein aggregation;Protein Chemistry;Protein Dynamics;protein function;Proteins;Proteomics;public health relevance;Publishing;Recombinant Proteins;Research;Role;Serine;Serine/Threonine Phosphorylation;Silicon Dioxide;Site;stereochemistry;Structure;sugar;synthetic protein;Testing;Therapeutic;Threonine;Toxic effect;unnatural amino acids;Western Blotting;Work

PROJECT_TITLE: Functional Analysis of O-GlcNAc using Synthetic Protein Chemistry

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE We propose a novel structurally, compositionally biomimetic bone scaffolding system that possesses osteoconductive and osteoinductive characteristics for orofacial cleft reconstruction. We will utilize 3D bioprinting strategies to develop personalized bone scaffolds for long-term use that will adapt to the needs of growing children. This proposed study will explore the potential of clinically applicable 3D bioprinting workflow using clinically relevant surgical animal models and utilize NIR fluorescent imaging technique as noninvasive real-time monitoring to determine the new bone formation along with implanted scaffold degradation.

PI_NAMEs: LEE, SANG JIN  (contact);SHIN, KYUNGSUP

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Affect;alveolar cleft;Alveolus;Anatomy;Animal Model;Architecture;Autologous;Biomimetics;bioprinting;bone;bone loss;Bone Matrix;Bone Morphogenetic Proteins;Bone Regeneration;bone scaffold;Bone Tissue;Bone Transplantation;Cells;Characteristics;Child;Cleft Lip;Cleft Palate;Clinical;clinical application;clinical practice;clinically relevant;Complex;Congenital Abnormality;Congenital Disorders;copolymer;craniofacial;Defect;demineralization;design;Development;effective therapy;Environment;Extracellular Matrix;Face;fluorescence imaging;fluorophore;Growth;Growth and Development function;Human;imaging platform;Imaging Techniques;Immune response;Impairment;Implant;improved;In Situ;In Vitro;in vivo;in vivo monitoring;interest;Investigation;Lip structure;Live Birth;Maxilla;Medical Imaging;Methodology;mineralization;Minerals;Modeling;Monitor;Morbidity - disease rate;Nasal cavity;Near-infrared optical imaging;non-invasive monitor;novel;novel strategies;Operative Surgical Procedures;Oral;Oral cavity;orofacial cleft;Oryctolagus cuniculus;Osteogenesis;osteogenic;Outcome;Patients;peptidomimetics;Physiologic calcification;Production;Property;psychosocial;real time monitoring;reconstruction;recruit;repaired;Respiratory physiology;Running;scaffold;self esteem;Series;Shapes;Site;skeletal;Soft Palate;standard care;stem cells;Structure;success;System;Technology;Testing;Therapeutic;Time;Tissue constructs;Tissue Engineering;Tissue Grafts;tissue reconstruction;tissue regeneration;Tissues;tricalcium phosphate;Validation;Work

PROJECT_TITLE: Clinically Applicable Orofacial Cleft Reconstruction Using Structural, Compositional Biomimetic Bone Scaffolds

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Our basic science research on dormancy will advance the NIH's mission of improving human health by finding methods of killing dormant fungal spores, many of which are infectious and cannot be readily killed by the existing antimicrobial drugs for reasons that are not well understood. The dormant spores of the baker's yeast, Saccharomyces cerevisiae, is a safe and an ideal model system because many of the basic biology of the baker's yeast also apply to infectious fungi such as those whose spores cause meningitis and histoplasmosis in humans. By revealing how dormant yeast spores age and the connections between gene expression and aging in dormancy, we expect to identify mechanisms that new drugs can disrupt to kill infectious fungal spores.

PI_NAMEs: YOUK, HYUN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Age;Aging;anti-microbial drug;Basic Science;Biological Models;Biology;cancer cell;Cells;Deceleration;detection method;extend lifespan;Face;Fungal Spores;fungus;Gene Deletion;Gene Expression;Gene Expression Regulation;Gene Library;Genes;Genetic Transcription;genome-wide;Goals;Health;Histoplasmosis;Human;Human body;improved;insight;interest;Knowledge;Laboratories;Life;mathematical model;Measurement;Meningitis;Messenger RNA;Methods;Microbe;microbial;Microscope;Mission;Nature;novel therapeutics;Nutrient;Organism;Pharmaceutical Preparations;Plants;Process;Production;Proteins;Reproduction spores;Research;Ribosomal Proteins;RNA;Role;Saccharomyces cerevisiae;Techniques;transcriptome sequencing;Translations;United States National Institutes of Health;virtual;Water;Work;Yeasts

PROJECT_TITLE: Dynamics in Eukaryotic Dormancy: Gene Expression and Aging

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Patient Safety;Prevention;Sarcoidosis;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Sarcoidosis is an understudied disease with significant morbidity and mortality that is a major health burden in the United States. This proposal will determine rates of medication adherence, evaluate the association between adherence and clinical outcomes in sarcoidosis, and identify which determinants are associated with medication adherence in individuals with sarcoidosis. It will also identify barriers and facilitators of adherence to inform the development of a behavioral intervention that targets knowledge gaps, improves coping, and addresses barriers to adherence in sarcoidosis.

PI_NAMEs: SHARP, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adherence;Affect;African American population;Anxiety;Azathioprine;Behavior Therapy;Behavioral;Belief;Biopsy;Caring;Characteristics;Chronic Disease;chronic respiratory disease;Clinic;Clinical;coping;Data;Development;Disease;Disease Progression;efficacy evaluation;Electronics;Emergency department visit;Enrollment;evidence base;Feedback;Future;Glucocorticoids;Goals;Health;health care service utilization;health disparity;health literacy;health related quality of life;Hospitalization;Impairment;improved;Incidence;Income;Individual;International;Interstitial Lung Diseases;Intervention;intervention refinement;Interview;Investments;Knowledge;Link;Longitudinal Studies;Low income;Lung Diseases;Measures;Medical Research Council Dyspnea Scale;medication compliance;medication nonadherence;Mental Depression;Mental Health;Methotrexate;Monitor;Morbidity - disease rate;mortality;Neurologic;Not Hispanic or Latino;Oral;Organ;Outcome;Participant;Patient Noncompliance;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacy facility;prevent;primary outcome;Prospective Studies;Pulmonary Fibrosis;pulmonary function;Pulmonary Heart Disease;Pulmonary Hypertension;Pulmonary Sarcoidosis;Qualitative Methods;Questionnaires;Recommendation;Records;Reporting;Research;respiratory;Sarcoidosis;Self Management;side effect;social determinants;Solid;Steroids;Stress;Sudden Death;Treatment Protocols;Treatment Side Effects;United States;user centered design;Walking

PROJECT_TITLE: Medication Adherence and Clinical Outcomes in Sarcoidosis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative This study is designed to investigate the effects of structural inventions, such as equity-focused Medicaid polices, on severe maternal morbidity and mortality and maternal health. The proposed study will 1) estimate the effect of Medicaid healthcare quality interventions on SMM, 2) estimate the effect of Medicaid healthcare quality interventions + doula care, 3) Assess Medicaid beneficiaries’ experiences in receiving services and the potential impact of integration of doula services and equity practices. The long-term objective is to inform state and federal health policymakers considering structural policy interventions within Medicaid as a vehicle for addressing racial equity

PI_NAMEs: JARLENSKI, MARIAN PATRICIA;MENDEZ, DARA DANEEN (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Adoption;Affect;beneficiary;Birth;Black Populations;Black race;bundled payment;care systems;Caring;Child Rearing;Chronic;community engagement process;community partners;COVID-19 pandemic;Data;design;Development;Discipline of obstetrics;Equity;experience;Exposure to;Focus Groups;Foundations;Funding;Goals;Health;health care quality;health equity;Health Policy;Healthcare;implementation evaluation;Improve Access;improved;Incentives;Inequity;innovation;Institution;integrated care;Intervention;Intervention Studies;Interview;invention;lens;Low Income Population;Managed Care;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Medicaid services;Methods;Modeling;multidisciplinary;obstetric care;Outcome;pandemic disease;payment;Pennsylvania;Personal Satisfaction;Persons;Phase;Police;Policies;Policy Maker;Population;post intervention;post pregnancy;Postpartum Period;Pregnancy;pregnancy health;pregnant;Prenatal care;programs;prospective;Public Health;Qualitative Research;Quality of Care;Race;racial disparity;Racial Equity;racial population;Research;Research Personnel;Resources;Services;severe maternal morbidity;social;social determinants;Source;standard care;structural determinants;Supportive care;United States;Wood material;Work

PROJECT_TITLE: The Effects of Medicaid Policy Interventions on Racial Equity in Severe Maternal Morbidity


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pulmonary Hypertension;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: About 10 million humans infected with the pathogen Schistosoma mansoni develop pulmonary arterial hypertension (Sch-PAH), which is characterized by obliteration and remodeling of pulmonary vasculature in response to pathogen eggs. Currently there are no targeted therapies for treatment of Sch-PAH. Thus, the overall goal of this proposal is to determine the mechanism that promotes generation of a vascular inflammatory endothelial memory and uncover novel pharmacological targets to prevent irreversible vascular remodeling during Sch-PAH.

PI_NAMEs: DOS SANTOS OLIVEIRA, SUELLEN D'ARC  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Abnormal Endothelial Cell;Acute;Address;Animal Model;Anti-Inflammatory Agents;Antigens;Apoptosis;Apoptotic;Area;Blood Vessels;Brazil;career;career development;caveolin 1;Caveolins;Cell Death;Cell Death Induction;Cell secretion;Cell Survival;Cells;Cessation of life;Characteristics;chemokine;Chicago;Chronic;Chronic Lung Injury;Chronic pulmonary heart disease;clinical development;Collaborations;Communities;Creativeness;Cultural Backgrounds;Curiosities;cytokine;Cytometry;Cytoprotection;Data;Dedications;Development;Development Plans;Disease;distinguished professor;Doctor of Philosophy;egg;Endothelial Cells;Endothelium;Environment;Evaluation;experience;Faculty;Fibrosis;Functional disorder;Generations;Goals;Growth;Human;hypertension treatment;Illinois;Immune;Immunity;Immunobiology;Impairment;imprint;In Vitro;in vivo;Induction of Apoptosis;Infection;Inflammation;Inflammatory;inhibitor;inhibitor of apoptosis protein 2;injured;Injury;insight;Institution;inter-institutional;Knowledge;Leadership;Learning;lectures;Lesion;Life;Lung;lung pressure;Lymphocyte;Mediating;Memory;Mentors;Methodology;Modeling;molecular modeling;Molecular Target;Mus;novel;overexpression;Parasites;Parasitic infection;pathogen;Persons;pharmacologic;Pharmacology;Phase;Phenotype;Phosphorylation;pre-clinical;prevent;Process;Proliferating;pulmonary arterial hypertension;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonary vessels;receptor;recruit;Reporting;Research;Research Personnel;Research Project Summaries;Research Subjects;Resistance;response;Scaffolding Protein;Schistosoma mansoni;Schistosoma mansonii infection;Signal Transduction;skills;Smooth Muscle Myocytes;Students;success;superresolution microscopy;targeted treatment;Technical Expertise;Testing;Th2 Cells;Therapeutic Embolization;Tissues;Training;Transforming Growth Factor beta;Universities;Vascular Diseases;Vascular Proliferation;Vascular remodeling;Vesicle;Voice;Woman

PROJECT_TITLE: Generation of Endothelial Cell Memory in Inflammatory Vascular Disease


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health

PHR: Public Relevance Statement There is an urgent need for innovative approaches that support the use of Preexposure Prophylaxis (PrEP), a daily pill preventing HIV that is empowering and user-controlled. Using a participatory implementation science framework, I will test whether an adapted and community empowered group healthcare model, Centering PrEP+, is a feasible and acceptable health system intervention to improve the health of sex workers and their clients by increasing PrEP adherence.

PI_NAMEs: SINGER, RANDI BETH (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Adoption;AIDS prevention;arm;California;career development;Chicago;Client;Clinic;cohort;Collaborations;Communities;community advisory board;community building;community empowerment;condoms;Country;design;Discrimination;Drops;Education;educational atmosphere;Educational Curriculum;Effectiveness of Interventions;effectiveness/implementation trial;empowerment;Evaluation;Evaluation Methodology;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Federally Qualified Health Center;Fostering;Foundations;Future;General Population;Goals;hands-on learning;Harm Reduction;Health;health assessment;health care delivery;health care model;health care service;Health Promotion;Health system;Healthcare;Healthcare Systems;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV/STD;Illinois;implementation barriers;implementation determinants;implementation facilitators;implementation framework;implementation process;improved;Individual;Infection;innovation;Intention;Intervention;Intervention Studies;Interview;Knowledge;Leadership;Link;Location;marginalized population;Mediation;Mentors;Methods;Modeling;Nurses;Outcome;Participant;Patient Care;patient oriented;patient population;Patients;pill;Pilot Projects;pilot trial;Population;Populations at Risk;Positioning Attribute;post intervention;Postpartum Period;pre-exposure prophylaxis;Pregnant Women;Prenatal care;Preparation;Prevalence;prevent;Prevention;Process;Provider;public health priorities;Qualifying;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;Research;Research Design;research study;Research Training;San Francisco;scale up;Scanning;Science;Scientist;Self Efficacy;Self Management;Services;sex;Site;skill acquisition;skills;social health determinants;social stigma;STI prevention;Strategic Planning;structural determinants;Structure;Surveys;Target Populations;Testing;therapy design;Training;transactional sex;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: Centering Those Engaged in Transactional Sex: A PrEP Innovation for Getting To Zero

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Leukemia;Digestive Diseases;Genetics;Hematology;Kidney Disease;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE With current high-dose/intensity surgery/chemo-radiation therapy, the 5-year event-free survival for children and adolescents/young adults with advanced, relapsed, or metastatic solid tumors is less than 30%, with little improvement in outcome for over 30 years. In addition, for those patients that survive their cancer, life-long and life-threatening sequelae from therapy may afflict up to half. This competing U01 Ped-In Vivo-TP application aims at identifying and developing novel, effective, targeted, and nano-formulated agents in omically characterized patient derived xenograft models representing high-risk sarcoma, kidney cancers, and hepatoblastoma. The program will facilitate pediatric drug development as directed by FDA under the Research to Accelerate Cures and Equity for Children Act (RACE for Children Act).

PI_NAMEs: KURMASHEVA, RAUSHAN  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Adolescent;Adopted;Alveolar Rhabdomyosarcoma;Antibody-drug conjugates;antitumor effect;Biological Products;biomarker identification;Brain Neoplasms;cancer cell;cancer type;CD276 gene;Cell Line;Characteristics;chemoradiation;chemotherapy;Child;Childhood;Childhood Cancer Treatment;Childhood Solid Neoplasm;Clinical;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Cyclophosphamide;Data;Databases;design;Development;Diagnosis;Disease;Disease-Free Survival;disorder risk;DNA Damage;DNA Repair;Dose;Drug Combinations;Drug Delivery Systems;Drug Formulations;Drug Targeting;efficacy evaluation;Embryonal Rhabdomyosarcoma;Enrollment;Epigenetic Process;Equity;Ewings sarcoma;exceptional responders;exome sequencing;expectation;Experimental Designs;Foundations;Genetic;Goals;Growth;Hepatoblastoma;Heterogeneity;high risk;high risk population;High-Risk Cancer;humanized mouse;Immunooncology;improved;In complete remission;in vivo;inhibitor;Investigation;irinotecan;kidney clear cell sarcoma;leukemia;Life;Link;Lipids;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MEKs;Modeling;Molecular;Molecular Target;mouse model;Mus;mutant;Mutation;nano;nanoformulation;nanoparticle;nanosystems;neoplastic cell;Nephroblastoma;New Agents;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;patient stratification;Patients;pediatric drug development;Pediatric Oncology Group;pediatric patients;Pharmaceutical Preparations;Phase;Phase I/II Clinical Trial;phase II trial;pre-clinical;Pre-Clinical Model;preclinical study;Preclinical Testing;Probability;programs;prospective test;Protocols documentation;public-private partnership;Race;radiation resistance;radiation response;Radiation therapy;radioresistant;Relapse;Renal Carcinoma;Reproducibility;Research;Resistance;Resources;response;response biomarker;Rhabdoid Cell;Rhabdoid Tumor;Rhabdomyosarcoma;ROR1 gene;Sarcoma;screening;Signal Transduction;Sirolimus;small molecule;Solid Neoplasm;success;Surface;systemic toxicity;targeted agent;Test Result;Testing;Therapeutic;transcriptome sequencing;Translating;translational impact;Trastuzumab;tumor;United States National Institutes of Health;Validation;Vinca Alkaloids;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: A Testing Program to Identify Novel Agents for Treatment of Pediatric and AYA High-Risk Sarcoma, Kidney and Liver Cancer


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN MARCOS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: PROJECT NARRATIVE The Bridges to the Doctorate Research Training Program at CSU San Marcos with UCSD and TSRI will prepare students from underrepresented (UR) and disadvantaged groups for careers in biomedical and behavioral research and will serve to advance the goals of the National Institutes of Health to diversify the research workforce. A more diverse research workforce will better address the research needs of a diverse nation and thereby contribute to better health for all.

PI_NAMEs: CORBETT, KEVIN DANIEL;EASTMOND, DAWN LISA;GARCIA, DENISE ;JAMESON, JULIE M (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: bridge to the doctorate;Research Training;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Pesticides, fungicides and insecticides are established risk-factors for neuronal injury and neurodegenerative onset. Here, we develop and test whether Carbon Quantum Dots (CQDs), which are nano materials synthesized from bio-waste precursors such as fruit peel, lignin, used frying oil and recycled paper, can restore cellular and organismal-level deficits induced by pesticide exposure. The proposed work is important because, if successful, it defines novel candidates that mitigate pesticide-associated neurodegenerative disorders.

PI_NAMEs: NARAYAN, MAHESH  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acids;Address;Agriculture;alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid formation;Amyloid Proteins;amyloidogenesis;Animal Model;Antioxidants;Apoptosis;Architecture;Attenuated;Automobile Driving;Behavioral;Biological Assay;biomaterial compatibility;Biosensing Techniques;Blood - brain barrier anatomy;blood-brain barrier crossing;Caenorhabditis elegans;Carbon;Cell membrane;Cell model;Cells;chemical synthesis;Chemicals;Chemistry;Complex;Coupled;cytotoxicity;Data;design;Development;Disease;dopaminergic neuron;Dose;Drug Delivery Systems;Egg White;Epidemiology;Event;Exposure to;Extravasation;Fluorescence;Fruit;fungicide;gene therapy;Generations;Heat-Shock Proteins 70;Herbicides;Homeostasis;Household;Human;Huntington Disease;Huntington gene;Impairment;In Vitro;in vivo;Industrialization;Injury;Insecticides;Insulin;islet amyloid polypeptide;light scattering;Lignin;Link;locomotor deficit;Maneb;Measures;Minority;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;multicatalytic endopeptidase complex;Muramidase;mutant;nanomaterials;National Institute of Environmental Health Sciences;National Institute of General Medical Sciences;Natural Products;Nematoda;Nerve Degeneration;Neuroblastoma;Neurodegenerative Disorders;Neurologic;neuron loss;Neuronal Injury;Neurons;neurotoxic;Neurotoxins;Neurotransmitters;nitrosative stress;novel;Oils;organic acid;Organic Synthesis;Organism;Outcome;Output;overexpression;Oxidative Stress;Paper;Paraquat;Parkinson Disease;Pathologic;Pest Control;pesticide exposure;Pesticides;phosphoneuroprotein 14;Phytochemical;polyphenol;pre-clinical;preclinical trial;prevent;Prophylactic treatment;protein aggregation;Proteomics;Quantum Dots;Reactive Nitrogen Species;Reactive Oxygen Species;Recycling;Reporting;Research;response;Risk Factors;Rodent;Role;Rotenone;small molecule;Solubility;Stress;success;Surface;Techniques;Testing;theranostics;Tissue imaging;Toxic effect;Toxic Environmental Substances;Translating;translational potential;Ubiquitin;Underrepresented Students;Up-Regulation;wasting;Woman;Work

PROJECT_TITLE: Development and testing of Carbon Quantum Dot architectures to arrest neurotoxicant-insult- related outcomes


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PHR: Narrative: TPI Df is an untreatable metabolic disease. Although disease pathogenesis is known to result from inappropriate targeting of functional mutant protein for degradation, drug therapies do not exist for this disease. We have developed an optical cellular assay for compounds that stabilize mutant TPI, and will use the platform to screen a diversity compound library and identify starting points for development into the first in class TPI Df small molecule therapies. We will prioritize molecules using toxicology and metabolism assays, and validate the most promising compounds in TPI Df patient cells and in vivo using established Drosophila and mouse models. Overall, this project will discover initial therapies for development and test efficacy of our lead compounds in TPI Df models, including a newly validated mouse model.

PI_NAMEs: PALLADINO, MICHAEL JOHN (contact);VOGT, ANDREAS

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: Acute;Amino Acid Substitution;Anemia;Automation;Biochemical;Biological Assay;Brain Injuries;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular Assay;Cessation of life;Chemicals;Childhood;Chronic;Clinical;Clinical Trials;Collection;combinatorial chemistry;Data;Defect;Deficiency Diseases;Development;Diagnosis;Disease;Dose;Drosophila genus;early childhood;efficacy testing;Enzymes;Equipment;Exhibits;Flow Cytometry;fly;Foundations;Functional disorder;Genetic;Genetic Models;Genetic Screening;genome wide screen;Heat-Shock Proteins 70;Heat-Shock Proteins 90;Heterozygote;Human;Image;Impairment;In Vitro;in vivo;in vivo evaluation;Inpatients;Intervention;Isomerase;Laboratories;Lead;Libraries;Library Collection Development;life span;Longevity;Mammals;Mediating;member;Metabolic Diseases;Metabolism;Methodology;Missense Mutation;Modeling;Motor;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Neurologic;neuromuscular;novel;Optics;Paralysed;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;premature;Property;Proteasome Inhibitor;protein degradation;protein function;Proteins;Quality Control;reduce symptoms;response;screening;Severity of illness;small molecule;Structure-Activity Relationship;System;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;Toxic effect;Toxicology;Triose-Phosphate Isomerase;Ubiquitin;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: High-content screening for TPI Deficiency therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]