ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Pulmonary arterial hypertension is a life-threatening disease that affects predominantly females of childbearing age characterized by progressive small vessel loss and right heart failure. Most current therapies work by dilating blood vessels, but no treatments have been found that can restore angiogenesis and prevent loss of small vessels. The research project presented here aims at understanding how lack of proper endothelial-pericyte interactions contributes to inappropriate angiogenesis and the role that the Wnt/planar cell polarity pathway plays as a major orchestrator for this event in the pulmonary circulation.

PI_NAMEs: DE JESUS PEREZ, VINICIO A (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Affect;angiogenesis;Binding;Blood capillaries;Blood Vessels;BMPR2 gene;Calcium Signaling;Cardiac;Cell Communication;Cells;chromatin immunoprecipitation;Chronic;Clinical;Coculture Techniques;CRISPR/Cas technology;CSPG4 gene;density;Development;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;epigenetic regulation;Event;exosome;Female of child bearing age;Functional disorder;Gene Expression;Genetic Transcription;genomic locus;Goals;Histone Deacetylation;Hyperplasia;Hypoxia;improved;insight;Knockout Mice;Life;Ligands;Lung;lung microvascular endothelial cells;lung pressure;Methylation;Morphogenesis;Mus;Natural regeneration;novel therapeutics;overexpression;Pathogenesis;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pericytes;Physiological;planar cell polarity;Play;prevent;Production;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Circulation;Pulmonary Hypertension;pyrosequencing;Rattus;receptor;Recovery;recruit;Repression;Research Project Grants;response;right ventricular failure;right ventricular remodeling;Role;Severities;Signal Pathway;Signal Transduction;Signaling Protein;single nucleus RNA-sequencing;Surface;Testing;Tissues;Transgenic Mice;Vascular remodeling;Ventricular;WNT5A gene;Work

PROJECT_TITLE: Endothelial-pericyte interactions in the pathogenesis of pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: OVERALL NARRATIVE Lung cancer is the number one cause of cancer death in the United States and the Yale SPORE in Lung Cancer is designed to identify novel biologic pathways and test new therapeutic approaches to interfere with lung cancer progression and metastasis. All three projects in the SPORE will initiate Yale-led novel clinical trials and will promote bench to bedside research within the center. This program has the potential to make significant impact in guiding the selection of therapies most likely to provide benefit to lung cancer patients with treatment refractory disease in the primary or metastatic setting.

PI_NAMEs: HERBST, ROY S (contact);POLITI, KATERINA ABIGAIL

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Address;Adoption;Animal Disease Models;anti-cancer research;Area;Award;bench to bedside;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biology;biomarker development;biomarker evaluation;Biometry;Biopsy;Blood;Brain;Brain Neoplasms;cancer cell;cancer drug resistance;Cancer Etiology;Cancer Hospital;Cancer Patient;cancer therapy;career;Cell surface;Cells;Central Nervous System;Cessation of life;Clinical;clinical application;clinical care;Clinical Research;Clinical Trials;clinically actionable;combat;Comprehensive Cancer Center;Connecticut;design;Development;Diagnosis;Disease;DNA Sequence Alteration;Drug resistance;effectiveness evaluation;Environment;Epidermal Growth Factor Receptor;Epigenetic Process;Frequencies;Funding;Gene Expression;Generations;Genetic;Genomics;Goals;Grant;Human;Human Cell Line;Immune;Immune response;Immunologics;Immunooncology;Immunosuppressive Agents;Immunotherapy;improved;In Vitro;in vivo;innovation;Liquid substance;Lung Adenocarcinoma;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;Mutation;Myeloid Cells;Neoplasm Metastasis;next generation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Outcome;outreach;Pathology;Pathway interactions;Patient Selection;Patients;personalized medicine;pharmacologic;Physicians;Pre-Clinical Model;prevent;Production;Productivity;programmed cell death ligand 1;programs;prospective;Proteins;Protocols documentation;Pulmonary Challenge;Recording of previous events;Refractory Disease;Reproduction spores;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Sampling;Scientist;Selection for Treatments;Solid Neoplasm;Source;Speed;Structure;T-Lymphocyte;targeted treatment;Testing;Translating;translational cancer research;translational research program;translational scientist;translational study;tumor;tumor microenvironment;tumor progression;Tyrosine Kinase Inhibitor;United States;Yale Cancer Center

PROJECT_TITLE: Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer


PHR: PROJECT NARRATIVE The Administration Core (Core A) is essential for leading the Yale SPORE in Lung Cancer (YSILC). The Core provides scientific, financial and administrative oversight for all YSILC activities and make critical decisions regarding project oversight and management.

PI_NAMEs: HERBST, ROY S (contact)

PROJECT_TERMS: Acceleration;Achievement;Advocacy;Advocate;anti-cancer research;Basic Science;Biology;career;Clinical;Clinical Research;Collaborations;Communication;Consultations;cost effective;Data;Development;Disputes;Ensure;Evaluation;Foundations;Funding;Future;Goals;Grant;Human Resources;Human Subject Research;Infrastructure;Institution;Laboratory Finding;Leadership;Malignant neoplasm of lung;meetings;Monitor;National Cancer Advisory Board;National Cancer Institute;neoplasm resource;novel;Occupational activity of managing finances;operation;outreach;Patients;personalized medicine;Philanthropic Fund;Preparation;Principal Investigator;Privatization;Program Evaluation;programs;Progress Reports;Publications;Regulation;Research;Research Personnel;Research Priority;Resources;Series;Source;success;symposium;timeline;translational applications;translational cancer research;Translational Research;Translations;United States National Institutes of Health;Universities;website development;Yale Cancer Center

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Networking and Information Technology R&D (NITRD);Pain Research;Precision Medicine;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: FISHER, SUSAN J. (contact)

PROJECT_TERMS: Affect;Age;aged;Animal Model;Biological Markers;Biology;Blood;Cell Physiology;Cells;Chlorinated Hydrocarbons;Classification;Clinical;Clinical Data;clinical phenotype;community engagement;comparison control;Complex;computerized tools;Computing Methodologies;Data;Data Analytics;data integration;Data Set;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;diagnostic strategy;differential expression;Dimensions;Dioxins;Disease;disease classification;disease diagnosis;disease diagnostic;disease phenotype;Disease stratification;disorder subtype;effective therapy;Endometrial;endometriosis;environmental chemical;environmental chemical exposure;Enzyme-Linked Immunosorbent Assay;epidemiology study;Estrogens;eutopic endometrium;experience;experimental study;Fatty acid glycerol esters;Frequencies;Genetic;genetic association;Goals;Histologic;Individual;Infertility;Inflammatory;innovation;interdisciplinary approach;Ions;ketogentic;Laparoscopy;Laparotomy;Lesion;Link;Machine Learning;Maps;Mass Spectrum Analysis;member;metabolomics;Methods;Modality;Molecular;molecular marker;molecular phenotype;Molecular Profiling;multidisciplinary;multiple omics;novel;novel diagnostics;novel marker;Onset of illness;Operative Surgical Procedures;Pain;Pain Disorder;Pathway interactions;Patients;Phenotype;phenotypic data;phthalates;Play;Polychlorinated Biphenyls;potential biomarker;precision medicine;predictive signature;Process;protein biomarkers;Proteins;Proteome;Proteomics;Recurrence;Reporting;reproductive;Research;Research Personnel;Risk;Risk Estimate;Role;Sampling;Serology;Serum;Severity of illness;small molecule;symptomatology;systematic review;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;therapeutic target;Time;Tissue Sample;Tissues;tool;Training;Uterine cavity;Uterus;Woman;women's diagnosis

PROJECT_TITLE: Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis


PHR: CORE B: PROJECT NARRATIVE With a stellar team of biostatisticians and bioinformaticians, the Core will provide the whole spectrum of analytic support to all SPORE projects and investigators. The Core will ensure that all studies are properly designed and executed and that data are properly managed, analyzed, reported, published, and shared.

PI_NAMEs: MA, SHUANGGE  (contact)

PROJECT_TERMS: Achievement;Address;analytical method;anti-cancer research;Applications Grants;Award;Bioinformatics;Biology;Biometry;Biostatistics Shared Resource;Cancer Center;career;clinical biomarkers;Clinical Data;Clinical Trials;Collaborations;Communities;Computational Biology;cost effective;Data;Data Collection;data management;Data Management Resources;Deposition;design;Development;Ensure;experience;Fostering;Funding;Goals;Guidelines;Individual;innovation;interest;Lead;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Medical center;Medical Informatics;Methods;Monitor;next generation;novel;personalized medicine;Play;Policies;Postdoctoral Fellow;posters;Process;programs;public repository;Publications;Publishing;Regulation;Reporting;Research;Research Design;Research Personnel;Role;Science;Services;Skin Cancer;student training;Training;Training and Education;training opportunity;United States National Institutes of Health;Visit

PROJECT_TITLE: Core B: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE: HIV-1 causes a life-long infection with no vaccines or cure available. Our goal is to understand how HIV-1 enters into the nucleus of cells, where it integrates into host genome and establishes infection, using advanced light microscopy techniques. This approach is expected to delineate HIV-1 nuclear import mechanisms and ultimately inform new HIV-1 treatment strategies.

PI_NAMEs: TORRES RIVERA, DARIANA  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Anti-viral Agents;Appearance;Architecture;Avidity;Binding;Capsid;Capsid Proteins;Cell Nucleus;Cells;Cellular biology;Centers for Disease Control and Prevention (U.S.);Complex;Cone;Core Protein;Cryoelectron Microscopy;Cyclophilin A;Cytoplasm;Data;Development;Diameter;Docking;Drug Targeting;Electron Microscopy;Fluorescent Dyes;Foundations;Genome;genomic RNA;Goals;HIV-1;Image;Imaging Techniques;Infection;Infection Control;insight;Integrase;Integration Host Factors;Interferons;Kinetics;Label;Light;light microscopy;live cell imaging;Long Terminal Repeats;Measures;Mediating;Microscopy;Modeling;Molecular;mutant;Myxovirus;novel;Nuclear;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nucleoplasm;Optics;overexpression;Persons;Physiological;Play;Process;Productivity;protein B;protein Mx;Proteins;reconstruction;Research;Resistance;response;Ribonucleoproteins;RNA-Directed DNA Polymerase;Role;Shapes;Site;Structure;superresolution imaging;superresolution microscopy;Techniques;Testing;Training;treatment strategy;vaccine access;Vaccines;Viral;viral genomics;Viral Reverse Transcription;Virion;virology;Virus;Visualization;Work

PROJECT_TITLE: Delineating HIV-1 nuclear import mechanisms through capsid interaction with MxB and the nuclear pore complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-H(20)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

PHR: NARRATIVE The Biospecimen, Pathology and Genomics Core (Core C) is a required component of all SPORE applications. Core C will serve as a comprehensive biorepository and distribution mechanism for all lung cancer cases at Yale. Core C will also assist and facilitate conventional and cutting edge tissue analysis needs for all of the SPORE projects.

PI_NAMEs: RIMM, DAVID L (contact)

PROJECT_TERMS: Appointment;Authorship;Award;biobank;Bioinformatics;Biological Assay;Biological Markers;Biology;Biometry;Biopsy;Blood;career;Cerebrospinal Fluid;Clinical;Collection;cytokine;Data Analyses;Development;Diagnostic;DNA;Excision;Funding;genome analysis;Genomics;Genotype;Goals;Health;High-Throughput Nucleotide Sequencing;Human;Immune;Immunologic Monitoring;Joints;K-Series Research Career Programs;Leadership;Malignant neoplasm of lung;Measurement;Medicine;meetings;Messenger RNA;Mission;Modality;molecular marker;molecular pathology;Needle biopsy procedure;Neoplasm Metastasis;novel;Operating Rooms;Pathologic;Pathology;Patients;personalized medicine;Plasma;Positioning Attribute;Postdoctoral Fellow;Preparation;Primary Neoplasm;professor;Protein Tyrosine Kinase;Proteins;Recurrence;Research;Role;Science;Scientist;Serum;Services;Signal Pathway;Specimen;success;Supervision;Surgeon;Time;Tissue Banks;Tissue Procurements;Tissue Sample;Tissues;tumor DNA;Tumor Tissue;tumor-immune system interactions;Work

PROJECT_TITLE: Core C: Biospecimen, Pathology, and Genomics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunization;Immunotherapy;Lung;Lung Cancer;Precision Medicine

PHR: PROJECT NARRATIVE Recent advances in immune modulating therapies, such as antibodies that target PD-1/B7-H1(PD-L1), have shown efficacy in the treatment of NSCLC, however response rates, although higher than traditional chemotherapy regimens, remain low. Studies identifying and understanding the mechanisms that result in inhibition of the immune system to target tumor are imperative to develop more effective therapies. In this proposal we investigate the role of siglec-15, a molecule recently identified as an immune regulator, in promoting a tumor phenotype that restricts tumor infiltrating T cell activation, and we explore potential biomarkers and combination treatment approaches to improve NSCLC therapeutic responses.

PI_NAMEs: CHEN, LIEPING  (contact)

PROJECT_TERMS: Ablation;Adverse event;anti-4-1BB;Antibodies;Antibody Therapy;antigen-specific T cells;Antigens;AXIN1 protein;Basic Science;Binding;Biological Markers;Biological Response Modifiers;Biology;biomarker validation;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;Cell Culture System;Cells;Cellular Structures;checkpoint therapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Classification;Clinic;Clinical;Clinical Sciences;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;cytokine;Cytometry;Data;design;Dose;effective therapy;effector T cell;Flow Cytometry;Foundations;Future;genome-wide;Germ Lines;Hodgkin Disease;Homologous Gene;Hospitals;Human;IgG4;Immune;Immune checkpoint inhibitor;Immune Evasion;immune function;Immune system;Immunity;Immunofluorescence Immunologic;Immunoglobulins;immunomodulatory therapies;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor therapy;Interferon Type II;Lectin;Ligands;Macrophage;Macrophage Colony-Stimulating Factor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;Myeloid Cells;Names;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel strategies;novel therapeutic intervention;Pathology;Pathway interactions;patient derived xenograft model;patient response;Patients;personalized medicine;Pharmaceutical Preparations;Phase;Phase I/II Clinical Trial;Phase II Clinical Trials;Phenotype;potential biomarker;prevent;programmed cell death ligand 1;programmed cell death protein 1;prospective;Proteins;receptor;Research Personnel;Resistance;resistance mechanism;response;Role;Safety;safety testing;Sialic Acids;Solid Neoplasm;Specimen;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;tool;Translational Research;treatment response;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor Tissue;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;validation studies;Work

PROJECT_TITLE: Project 1: Siglec15 as a new target for lung cancer immunotherapy


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Phosphodiesterases control subcellular cyclic nucleotide signaling for specific cellular responses, including gene expression. We aim to uncover the mechanisms on how phosphodiesterase 4D5 controls adrenergic receptor signal to the nucleus for gene expression during learning and memory.

PI_NAMEs: XIANG, YANG K (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: A kinase anchoring protein;Adrenergic Agents;Adrenergic Receptor;Affect;Agonist;Alanine;Anxiety;arrestin3;Arrestins;beta-2 Adrenergic Receptors;beta-adrenergic receptor;Binding;biological adaptation to stress;Biosensor;Cell membrane;Cell Nucleus;Cognition;Complex;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic Nucleotides;Data;Dementia;Development;Disease;Dopamine Receptor;Endocytosis;Endosomes;Family;Fibroblasts;Fluorescence Resonance Energy Transfer;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Genetic;Hippocampus;Human;Impairment;inhibitor;Ion Channel;Knock-out;Knockout Mice;Learning;Literature;Mediating;Memory;Mental Depression;morris water maze;Mus;Muscle Cells;nanobodies;neuronal excitability;Neurons;novel;Nuclear;Nuclear Export;overexpression;phosphoric diester hydrolase;Phosphorylation;Physiological;Play;Post-Traumatic Stress Disorders;Protein Isoforms;Proteins;receptor;Receptor Signaling;recruit;Regulation;response;Rodent;Role;scaffold;Serine;Shapes;Signal Transduction;Signaling Protein;Site;System;Tissues;Training;Transgenic Mice

PROJECT_TITLE: Phosphodiesterases govern nuclear cAMP signaling for gene expression

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Pain Research;Women's Health Research

PI_NAMEs: SIROTA, MARINA  (contact)

PROJECT_TERMS: Affect;Animal Model;Bar Codes;Behavioral;Bioinformatics;Biological Assay;cell type;Cells;chronic pelvic pain;Clinical;Clinical Trials;Collaborations;Combination Drug Therapy;Combined Modality Therapy;community engagement;COVID-19;cytokine;Cytometry;Data;Databases;Dermatomyositis;Development;Disease;Drug Combinations;drug development;drug repurposing;Drug Screening;Drug Targeting;Dysmenorrhea;Dyspareunia;efficacy evaluation;Endometrial;endometriosis;Equipment;Estrogens;Excision;Functional disorder;Gene Abnormality;Gene Expression;Gene Expression Profile;Genomics;Goals;Hormonal;Hormones;Human;Immune;immunoregulation;improved;in silico;In Vitro;in vivo;Infertility;Inflammatory;Inflammatory Bowel Diseases;innovation;interest;Interleukin-1 beta;Interleukin-6;Libraries;Malignant neoplasm of lung;Maps;Mediating;Medical;Menstrual cycle;Modeling;Molecular;Molecular Profiling;multidisciplinary;Network-based;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Pain;Pathogenesis;Pelvic Pain;Pelvis;Pharmaceutical Preparations;Phase;Phenotype;pre-clinical;Pre-Clinical Model;preclinical development;Premature Birth;Process;Property;Prostaglandins;Public Domains;Quality of life;reduce symptoms;Relapse;Research;response;Rodent Model;screening;Signal Pathway;Signal Transduction;skills;Symptoms;Techniques;Technology;Teenagers;Testing;Therapeutic;therapeutic candidate;Tissues;TNF gene;Training;transcriptomics;Translational Research;Validation;Woman

PROJECT_TITLE: Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Lung;Lung Cancer;Precision Medicine

PHR: PROJECT NARRATIVE Targeted therapies have completely transformed the landscape for diagnosis and treatment of metastatic EGFR mutant lung cancer. Despite this success, even the newest targeted therapies, like osimertinib, are not curative and acquired resistance is a major impediment to cures for patients. We will use our collective expertise in lung cancer biology, mouse models and EGFR structural biology to obtain a comprehensive understanding of osimertinib resistance and insight with which to develop new mechanism-based approaches to target osimertinib-resistant tumors – an urgent unmet clinical need.

PI_NAMEs: POLITI, KATERINA ABIGAIL (contact)

PROJECT_TERMS: acquired drug resistance;Address;Adoption;Antibodies;Automobile Driving;Binding;Biochemical;biochemical tools;Biochemistry;Biology;Cancer Biology;chromatin remodeling;Clinic;Clinical;Data;Development;Diagnosis;Dimerization;DNA Sequence Alteration;Epidermal Growth Factor Receptor;Epigenetic Process;Erlotinib;Exons;Family member;Frequencies;Gefitinib;Gene Expression Profile;Generations;Genes;genomic tools;Genotype;Heterodimerization;Homo;improved outcome;In Vitro;in vivo Model;innovation;insight;Knowledge;Lung Adenocarcinoma;Malignant neoplasm of lung;Mediating;Modeling;Molecular;mouse model;mutant;Mutate;Mutation;Nature;novel therapeutics;Oncogenic;Pathway interactions;patient response;patient subsets;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;Progression-Free Survivals;Property;receptor;Resistance;resistance mechanism;resistance mutation;Resources;Role;SMARCA4 gene;Speed;structural biology;success;targeted treatment;Testing;Therapeutic;Therapeutic Studies;Toxic effect;treatment strategy;tumor;tumor initiation;tumor progression;Tyrosine Kinase Domain;Tyrosine Kinase Inhibitor;Variant

PROJECT_TITLE: Project 2: Mechanism-based approaches to counter TKI resistance in EGFR mutant lung cancer


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Genetics;Lung;Lung Cancer;Neurosciences;Precision Medicine

PHR: PROJECT NARRATIVE  Thoracic malignancies frequently metastasize into the brain, which significantly diminishes patient survival and quality of life. Our novel multi-disciplinary approach proposes to reveal markers and mediators of brain metastasis from lung cancer patients at the time of their diagnosis. We believe that this project will reveal fundamental new methods of identifying lung cancer patients with treatment refractory brain metastasis as well as provide more tailored therapeutic opportunities to treat their disease.

PI_NAMEs: NGUYEN, DON X (contact)

PROJECT_TERMS: actionable mutation;beta catenin;bevacizumab;Biological;Biology;biomarker identification;Biopsy;Blood - brain barrier anatomy;Blood Vessels;Brain;brain control;Brain Neoplasms;Cancer Patient;CDK4 gene;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Neoplasms;Cephalic;cerebral microvasculature;Cerebrospinal Fluid;cerebrovascular;Clinical;Clinical Pathways;Clinical Trials;clinically actionable;cohort;Complement;Craniotomy;Diagnosis;Diagnostic;Disease;DNA Sequence Alteration;driver mutation;Drug resistance;effective therapy;Endothelium;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;exome sequencing;Gene Expression;Gene Mutation;Genetic;Genetic Drift;genetic evolution;Genomic approach;Growth;Human;improved;In Situ;in vivo;Incidence;insight;interdisciplinary approach;KDR gene;Leptomeninges;Ligands;Liquid substance;Malignant neoplasm of lung;Malignant neoplasm of thorax;Mediator;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Methods;Modeling;Molecular;Molecular Analysis;molecular marker;Monoclonal Antibodies;mutant;Mutation;Myelogenous;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;notch protein;novel;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;phase II trial;PIK3CG gene;Plasma;Pre-Clinical Model;prevent;Progression-Free Survivals;prospective;Protocols documentation;Quality of life;receptor expression;Refractory;Relapse;Resistance;response;response biomarker;Risk;Signal Transduction;Source;Specimen;Spinal Neoplasms;Spinal Puncture;Stromal Neoplasm;targeted agent;Testing;Therapeutic;Time;transcriptomics;tumor;tumor DNA;tumor microenvironment;tumor progression;Tumor Tissue;Tyrosine Kinase Inhibitor;Vascular Endothelial Growth Factors;Vascular remodeling;Vegf inhibition

PROJECT_TITLE: Project 3: Identifying and targeting mediators of CNS metastasis from lung cancer


PI_NAMEs: OPOKU-ANANE, JESSICA   (contact)

PROJECT_TERMS: Acceleration;Address;Advocate;Area;Awareness;black women;career;career networking;Clinical;clinical care;clinical practice;Clinical Research;clinical training;Collaborations;Communication;Communities;community engagement;Community Health Education;community involvement;Community Outreach;community partnership;Disadvantaged;Discipline of obstetrics;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;endometriosis;Event;experience;Family;Festival;Fostering;Future;General Population;Goals;Gynecology;Health education;health literacy;Health Personnel;Health Professional;high school;Infrastructure;innovation;inpatient service;interest;Internships;Laboratories;Leadership;lectures;literacy;member;Mentors;Methods;outreach;outreach program;patient population;Patients;people of color;Population Heterogeneity;Printing;programs;Questionnaires;Reproduction;Reproductive Sciences;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Resources;Risk Factors;Rotation;San Francisco;Science;social;social media;Structure;student training;success;summer research;Surveys;symposium;Symptoms;Training;Training Programs;Translating;Translations;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;webinar;Women's Health

PROJECT_TITLE: Education and Community Engagement Core (Core B)


PHR: PROGRAM NARRATIVE The objective of this Developmental Research Program is to foster and develop innovative lung cancer translational research programs with objectives that align with the overall goals of the Yale SPORE in Lung Cancer. Projects of the highest caliber will be sought to possibly serve as replacements for the primary SPORE projects should productivity lag or other unforeseen circumstances arise.

PROJECT_TERMS: Agreement;anti-cancer research;Area;Award;Biology;Budgets;Caliber;cancer therapy;Carcinogenesis Mechanism;Clinical;Collaborations;Committee Members;Communities;Consultations;Development;Direct Costs;Early Diagnosis;Electronic Mail;Ensure;Financial Support;Fostering;Funding;Funding Mechanisms;Future;Goals;Guidelines;Human;innovation;Institution;Leadership;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Methods;minority investigator;Monitor;Morbidity - disease rate;mortality;new therapeutic target;novel;novel therapeutics;Outcome;personalized medicine;Pilot Projects;Prediction of Response to Therapy;Process;Productivity;prognosis biomarker;Program Research Project Grants;programs;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resource Sharing;Risk Assessment;Study Section;translational potential;translational research program;tumorigenesis;United States National Institutes of Health;Woman;Work;Yale Cancer Center

PROJECT_TITLE: Yale SPORE in Lung Cancer Developmental Research Program


PHR: PROGRAM NARRATIVE The Yale SPORE in Lung Cancer’s Career Enhancement Program is a key program to foster the development of the next generation of physician scientists focused on conducting research in the area of human thoracic malignancies to advance discoveries in the prevention, diagnosis, and treatment of lung cancer.

PI_NAMEs: KLUGER, HARRIET M. (contact)

PROJECT_TERMS: Address;anti-cancer research;Appointment;Area;Award;base;Basic Science;Biochemistry;Biological;Biology;Biophysics;career;clinical center;clinical investigation;Collaborations;Colon Carcinoma;Communities;design;Development;Diagnosis;Discipline;Faculty;Fellowship Program;Fostering;Foundations;Funding;Generations;Genetic;Goals;Growth;Human;Infrastructure;Institution;interest;knowledge base;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of thorax;Medical;Medical Oncology;Medical Research;medical schools;Mentors;Minority Recruitment;Molecular;next generation;novel;Pathology;Patients;personalized medicine;Pharmacology;Physicians;Prevention;Procedures;Process;programs;Pulmonology;recruit;Research;Research Personnel;Science;Scientist;Solid;Talents;Training;translational impact;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Work;Yale Cancer Center

PROJECT_TITLE: Yale SPORE in Lung Cancer Career Enhancement Program


NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Clinical Research;Maternal Health;Nutrition;Pediatric;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Transporters are proteins that required for nutrient absorption and secretion in the developing infant gut, and in the adapting maternal gut and lactating breast. Despite their critical role in maternal and infant health, human transporters are poorly understood due to challenges in obtaining human tissue derived models to study their function. Our Transporter Elucidation Center (TEC) on Minerals in Nutrition and Development (MINeD) will develop human organoid models to study physiologic mechanisms of intestinal and mammary gland adaptation to support pregnancy, development and lactation. It will support critical infrastructure, drive fundamental discovery and foster career development in the scientific areas of human transporter physiology.

PI_NAMEs: RAO, RAJINI  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;absorption;Adult;Affect;Area;Award;Basic Science;bench-to-bedside translation;Biopsy;Breast;career;career development;Carrier Proteins;Caseins;CCL21 gene;Cell membrane;Cells;Cellular Metabolic Process;Child;Child Development;Child Support;Childhood;Cholesterol;Clinical;Clinical Research;Collaborations;Communities;Complement 3d;Data;data visualization;Development;dietary mineral;Disease;Duodenum;Educational workshop;Engineering;Epithelial Cells;Ethics;Faculty;Family;Fatty acid glycerol esters;Female of child bearing age;Fostering;Funding;Future;gene editing technology;Generations;Genetic Transcription;Goals;hard metal;Health;health of the mother;Homeostasis;Hormones;Human;human data;Human Milk;human tissue;Image;Immune response;Immunohistochemistry;improved;In Vitro;in vitro Model;infancy;Infant;Infant Development;Infant Health;Infrastructure;innovation;instrumentation;Intestines;Ions;Knock-out;Knowledge;Lactation;lactogenesis;Link;Lipids;Mammaplasty;mammary;mammary epithelium;Mammary gland;Mammospheres;Maps;Mass Spectrum Analysis;Maternal Health;Mental Health;Mentors;metabolic imaging;Metals;Milk;milk production;milk secretion;Minerals;Modeling;Mothers;Names;Nutrient;nutrient absorption;nutrition;Nutritional Requirements;Organoids;Outcome;Physiological;Physiology;Pilot Projects;Play;Positioning Attribute;postnatal development;Pregnancy;Production;Proliferating;Proteome;Regulation;Research;Resources;response;RNA;Role;Sampling;Scientist;Series;Small Intestines;solute;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;symposium;three-dimensional modeling;Tissues;Trace Elements;Training;Triglycerides;uptake;web site;Work

PROJECT_TITLE: Minerals in Nutrition and Development


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: KENNESAW

ORG_NAME: KENNESAW STATE UNIVERSITY

PHR: Project Narrative With the increase in legalization of cannabis, prenatal exposure has increased significantly and is expected to rise. Currently, there are no therapeutic options to treat the cognitive deficits associated with prenatal cannabinoid exposure. The proposed project aims to elucidate the mechanism by which exposure to cannabinoids during pregnancy causes learning and memory deficits in offspring and proposes the use of a novel molecule that has been shown to correct memory deficits in a rodent model of cognitive impairment.

PI_NAMEs: REED, MIRANDA NICOLE;SUPPIRAMANIAM, VISHNU  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acids;Address;Adolescent;Affect;Animals;Attenuated;Behavioral;Behavioral Mechanisms;behavioral plasticity;Cannabinoids;Cannabis;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive task;Data;Development;Electrophysiology (science);Equilibrium;Exposure to;fetal marijuana exposure;flexibility;functional outcomes;Goals;Hippocampus;illicit drug use;Impaired cognition;Impairment;interdisciplinary approach;Lactation;Learning;Legal;Literature;Long-Term Depression;Long-Term Potentiation;Low income;marijuana legalization;marijuana use in pregnancy;Mediating;Memory;Memory impairment;memory retrieval;Methodology;mimetics;Molecular;N-Methyl-D-Aspartate Receptors;NCAM1 gene;Neurocognitive;neurogenesis;neuronal circuitry;Neurons;novel;offspring;p38 MAPK Signaling Pathway;Pathway interactions;Perception;Play;postsynaptic;pre-clinical;Prefrontal Cortex;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;presynaptic;Publishing;ras-GRF1;Rattus;receptor expression;Receptor Signaling;receptor-mediated signaling;Reporting;Residual state;Rodent Model;Role;Short-Term Memory;Signal Pathway;Signal Transduction;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;Woman

PROJECT_TITLE: Elucidation of molecular mechanisms of prenatal cannabinoid exposure: Identification of targets and therapies.

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative: Gastrointestinal pain and gastrointestinal disorders are remarkably prevalent issues among children and adults in the United States, which can have a profoundly negative impact on quality of life. Dorsal root ganglia neurons are sensory neurons that transmit painful and non-painful signals from the gastrointestinal tract to the central nervous system. The goal of this proposal is to understand how innocuous and noxious stimuli are transmitted to the spinal cord by dorsal root ganglia neurons and identify the spinal cord circuits that process gastrointestinal sensory information.

PI_NAMEs: MCKENZIE, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adult;Afferent Neurons;Anatomy;Axon;Calcitonin Gene-Related Peptide;Capsaicin;Central Nervous System;Chemicals;Child;Colon;colon distension;Communication;Computer software;Confocal Microscopy;Data;Dependovirus;Distal;dorsal column;dorsal horn;Electrodes;Electrophysiology (science);Esthesia;Exhibits;experimental study;gastrointestinal;Gastrointestinal Contents;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal Process;Gastrointestinal tract structure;Genetic;Genetic Markers;Goals;Histology;Image;in vivo;Injections;insight;Interneurons;Ion Channel;Irritants;Label;Link;Manuals;Mechanics;Methods;microbial;Modality;Morphology;mouse genetics;multi-electrode arrays;Mus;nerve supply;Nervous System;neural circuit;Neurons;neurotransmission;new therapeutic target;novel;open source;Operative Surgical Procedures;optogenetics;Organ;Pain;Pain Disorder;Painless;Pattern;Peripheral;Piezo 2 ion channel;Population;postsynaptic;Preparation;presynaptic;Presynaptic Terminals;programs;Property;Quality of life;Research;response;Role;Sensory;Signal Transduction;Sorting;Spinal Cord;Spinal cord posterior horn;Spinal Ganglia;Stimulus;Stretching;Structure;Synapses;Tissues;transmission process;United States;Viral;Viscera;Wild Type Mouse

PROJECT_TITLE: Anatomical and Functional Characterization of Gastrointestinal to Spinal Cord Circuits


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Primary Health Care;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE Chronic pain and opioid use disorder are major public health problems. The University of New Mexico (UNM) Integrative Management of chronic Pain and Opioid use disorder for Whole Recovery (IMPOWR) Center will take an integrated and holistic approach to improving the lives of patients with chronic pain and opioid use disorder via tailored intervention approaches to meet the needs of diverse individuals in diverse communities. This project supports the strategic goals of several NIH institutes by examining a difficult and understudied problem with the ultimate goal of impacting scientific knowledge and improving human health and well-being.

PI_NAMEs: PEARSON, MATTHEW RYAN;WITKIEWITZ, KATIE A (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Address;Alaska Native;Alaska Native population;American Indian Population;American Indians;biopsychosocial factor;Brain;Buprenorphine;chronic pain;chronic pain management;chronic pain patient;Client;Clinic;clinical pain;Collaborations;Common Data Element;Communities;community based participatory research;comorbidity;Consultations;Control Groups;cost effectiveness;Cost Measures;culturally appropriate intervention;Data Collection;data harmonization;design;economic evaluation;economic outcome;Education;effectiveness study;effectiveness testing;effectiveness/implementation hybrid;Evidence based treatment;experience;functional improvement;Funding;Goals;Health;health care settings;holistic approach;Human;hybrid type 1 design;implementation intervention;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;improved outcome;Individual;innovative technologies;Integrative Therapy;Intervention;Knowledge;Life;Lived experience;Measures;Mentors;Methods;mindfulness;motivational enhancement therapy;Native Americans;New Mexico;open data;opioid misuse;opioid use;opioid use disorder;organizational readiness;Outcome;Outcome Measure;Outpatients;outreach;Pain;patient level intervention;patient oriented;patient population;Patients;person centered;Personal Satisfaction;Persons;Pilot Projects;Pregnant Women;Primary Care;primary care clinic;primary care setting;Provider;psychosocial;Public Health;Quality Control;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;recruit;relapse prevention;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Science;screening;screening and brief intervention;Sex Differences;Site;social health determinants;social stigma;Technology;Testing;Time;Training;Treatment outcome;United States National Institutes of Health;Universities

PROJECT_TITLE: Integrative Treatment for Achieving Holistic Recovery from Comorbid Chronic Pain and Opioid Use Disorder


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Retinitis pigmentosa (RP) affects 1 in 3000 individuals and is the most common inherited retinal dystrophy. This project will investigate the knowledge gap of cellular metabolism in Cone and RPE, and test potential therapy of reprograming cellular metabolism in mouse model of RP.

PI_NAMEs: WANG, NAN-KAI  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Affect;Alleles;Anabolism;Animals;Biology;Blindness;Carbon;Catabolism;Cell Reprogramming;Cells;Cessation of life;Citric Acid Cycle;Cone;Consumption;Coupled;Coupling;Cre driver;CRISPR/Cas technology;deprivation;design;Disease;Future;Gene Mutation;gene therapy;gene therapy clinical trial;Genes;Genetic Heterogeneity;genetic manipulation;Glucose;Glycolysis;Goals;Guide RNA;Hypoxia Inducible Factor;Individual;Inherited;innovation;Intervention;Knock-in Mouse;Knock-out;Knowledge;Metabolic;Metabolism;metabolome;Modeling;mouse model;Mutation;novel;overexpression;Oxidative Phosphorylation;Pathway interactions;Patients;Phase;photoreceptor degeneration;Photoreceptors;PPAR gamma;pre-clinical;Pre-Clinical Model;Preclinical Testing;prevent;Procollagen-Proline Dioxygenase;programs;repaired;Residual state;Retina;Retinal Cone;Retinal Degeneration;Retinal Dystrophy;retinal prosthesis;retinal rods;Retinitis Pigmentosa;Rod;Role;RPE65 protein;Source;Starvation;Structure of retinal pigment epithelium;targeted treatment;Testing;therapeutic evaluation;Therapeutic Intervention;therapy development;Vertebrate Photoreceptors;Viral Vector;Virus;Work

PROJECT_TITLE: Reprogramming the metabolome to overcome the genetic heterogeneity in retinitis pigmentosa

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The proposed R01 will use a randomized controlled trial to assess the impact of a brief attachment-based intervention on emergent child health outcomes (i.e., common childhood illnesses, low-grade inflammation, body mass index, and sleep) in a sample of low-income Latino children (N=260; 9 months at baseline). Pre- and post-intervention assessments will include health outcomes, mediating processes, and contextual modifiers that may amplify the effects of the intervention. Study findings stand to transform the nature and timing of preventive interventions to reduce health disparities that disproportionately impact Latino families and will advance understanding of early social influences that promote healthy development across the lifespan.

PI_NAMEs: BERLIN, LISA J (contact);SLOPEN, NATALIE

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Academy;Acculturation;Age;American;American Heart Association;biobehavior;Biological;Body mass index;caregiving;Child;Child Health;Child Rearing;Childhood;Community Networks;COVID-19 pandemic;design;Development;Discrimination;Economics;efficacy testing;Emotional;Enrollment;Environment;ethnic health disparity;experience;Face;Family;Fostering;Foundations;Future;Health;health disparity;Health Promotion;high risk;Home;Household;Immigrant;improved;Infant;Inflammation;innovation;Intervention;intervention effect;Investigation;Latina;Latino;Latino Population;Life;Life Cycle Stages;life span;Low income;Manuals;Mediating;Mediator;minority children;Modeling;Mothers;National Institute of Child Health and Human Development;Nature;Obesity;Observational Study;Outcome;parenting intervention;Parents;Pediatrics;physical conditioning;Population;post intervention;prevent;preventive intervention;primary caregiver;Process;Psychophysiology;racial health disparity;Randomized, Controlled Trials;Reduce health disparities;Regulation;Research;respiratory;Risk;Sampling;Secure;Security;Skin;Sleep;Sleep Deprivation;social;social culture;social health determinants;social influence;social stressor;Stress;Subgroup;Testing;Toddler;trial design;United States National Institutes of Health;Work

PROJECT_TITLE: Effects of Attachment-Based Intervention on Low-Income Latino Children's Emerging Health Outcomes: A Randomized Controlled Trial

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Louisiana's children are affected by many health problems at a higher rate compared to other states. This is especially true in rural areas and areas that have less access to healthcare. The goals of this proposal are to expand access to cutting-edge research for more children in Louisiana, to train future pediatric researchers, and to address the specific health needs of children locally and nationally. We will accomplish these goals by combining resources and a team of researchers from Pennington Biomedical Research Center, Tulane University, LSU Health Sciences Center, and the state's only 2 freestanding children's hospitals, Children Hospital New Orleans, and Our Lady of the Lake Children's Hospital in Baton Rouge.

PI_NAMEs: CARLSON, JOHN C;STAIANO, AMANDA E. (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: academic program;Address;Affect;Age;Area;Asthma;autism spectrum disorder;Biomedical Research;Birth;Books;Budgets;Cardiovascular Diseases;Center for Translational Science Activities;Cessation of life;Child;Child Health;Child health care;Child Welfare;Childhood;Clinic;clinical infrastructure;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;Conduct Clinical Trials;Country;Data;Death Rate;design;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;disorder risk;Disparity;Enrollment;Ensure;experience;Faculty;Fetal health;Future;Goals;Grant;Health;health care availability;health disparity;Health Sciences;High Prevalence;Hospitals;improved;Infant;Infant Mortality;Infrastructure;innovation;Institution;Intellectual functioning disability;inter-institutional;Live Birth;Louisiana;Low Birth Weight Infant;Mentors;Modeling;Multi-Institutional Clinical Trial;neurodevelopment;Obesity;operation;Outcome;Patient Recruitments;Pediatric Hospitals;Pediatric Research;Pediatrics;Perinatal;Population;Positioning Attribute;postnatal;prenatal;Prevalence;Process;Program Development;programs;Protocols documentation;recruit;Research;Research Infrastructure;Research Personnel;Resources;Risk;Risk Reduction;Rural;rural area;Scientist;senior faculty;Site;sixth grade;skill acquisition;skills;Supervision;synergism;System;Teacher Professional Development;timeline;Training;Translating;Translational Research;underserved area;United States;United States National Center for Health Statistics;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Expansion of Clinical Trials Access to Rural and Underserved Children of Louisiana


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Liver Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative  Preoperative exercise therapy (PET) is a highly applicable non-pharmacological-based therapy and has successfully reduced postoperative complications and conferred better recovery from major liver surgery. This project will determine the mechanisms by which PET prevents liver ischemia/reperfusion injury which is an unavoidable consequence of major liver surgery by altering the trained immunity in hepatic resident macrophages (Kupffer cells), and the NET-induced local and systemic inflammatory response. The finding from this proposal will provide the knowledge foundation for not only optimizing the development of PET against surgery-induced organ injury but also devising exercise-mimicking pharmacological strategies for patients who are exercise intolerant.

PI_NAMEs: HUANG, HAI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Abdomen;Adoptive Transfer;Animal Model;Anti-Inflammatory Agents;Attenuated;Cardiovascular system;cell type;Cells;Characteristics;chemokine;cost;cytokine;Cytometry;Data;design;Development;Environment;Enzyme-Linked Immunosorbent Assay;Excision;Exercise;exercise intervention;Exercise Therapy;Exhibits;extracellular;Flow Cytometry;Foundations;Functional disorder;Genetic;Goals;Hepatic;Human;Immune;immune function;Immunity;improved;improved outcome;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Injury;innate immune function;Intervention;ischemic injury;Knowledge;Kupffer Cells;Lead;Lipopolysaccharides;Liver;liver injury;liver ischemia;liver transplantation;Macrophage;Mediating;Mediator;Metabolic;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;Musculoskeletal Diseases;neutrophil;Neutrophil Infiltration;novel;novel strategies;Operative Surgical Procedures;organ injury;Outcome;Pathway interactions;Patients;Pattern;pharmacologic;Pharmacologic Substance;Phenotype;Play;Postoperative Complications;Postoperative Period;prevent;Process;Randomized, Controlled Trials;Recovery;Regulation;Reperfusion Injury;Reperfusion Therapy;response;Role;Secondary to;Serum;Signal Transduction;single cell technology;single-cell RNA sequencing;STAT3 gene;Stat3 Signaling Pathway;surgery outcome;systemic inflammatory response;Testing;Therapeutic;Training;Transaminases;transcriptomics;tumor-immune system interactions

PROJECT_TITLE: Preoperative exercise therapy for surgery triggered inflammation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The human fovea supports some of our most important visual functions, such as color discrimination and high- acuity vision, but there remain significant gaps in our understanding of foveal development and the exact causal relationships between structural pathology and specific visual deficits. Here we propose to employ human albinism (a condition in which the fovea is grossly underdeveloped) as a natural model to examine these and other key issues. Using advanced non-invasive imaging approaches, we seek to reveal the physiological and anatomical basis for visual deficits in albinism on a personalized basis and to refine the anatomical outcome measures for use in correlative studies and emerging therapeutic trials in albinism.

PI_NAMEs: CARROLL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Abbreviations;adaptive optics;adaptive optics scanning laser ophthalmoscopy;Address;Albinism;Alleles;Anatomy;Angiography;Behavior;Behavioral;Blindness;Clinical;Color;Complex;Cone;confocal imaging;Correlative Study;Data;density;Depth Perception;Development;Discrimination;Disease;Event;Eye;Fiber;Foundations;fovea centralis;Functional Magnetic Resonance Imaging;Future;Ganglion Cell Layer;Genetic;Genotype;Goals;Hair;Health;Hereditary Disease;Human;human subject;imaging approach;Impairment;improved;Individual;individual patient;insight;interdisciplinary approach;Interdisciplinary Study;interest;Iris;Knowledge;Light;Link;Literature;macula;Maps;Measurement;Melanins;Modeling;Molecular;Monophenol Monooxygenase;Morphology;mosaic;multidisciplinary;National Eye Institute;Neurons;non-invasive imaging;novel therapeutic intervention;Nuclear;Ocular Albinism;Oculocutaneous Albinism;Ophthalmoscopy;Optical Coherence Tomography;optical imaging;Outcome;Outcome Measure;Pathologic Nystagmus;Pathology;patient population;Patients;Phenotype;Photoreceptors;Photosensitivity;Physiological;Pigments;Prevalence;Privatization;Production;programs;Publications;Quality of life;Recording of previous events;Refractive Errors;Reporting;Research Personnel;Resolution;Retina;Retinal Cone;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;retinal rods;Rod;Role;Scanning;Severities;Skin;Structure;Structure of retinal pigment epithelium;Technology;Testing;Therapeutic;Therapeutic Trials;tool;Transillumination;Vision;Vision Disorders;Vision research;Visual;Visual Acuity;Visual System;Work

PROJECT_TITLE: Retinal Contributions to Vision Loss in Albinism


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Narrative Veterinarians play a key role in biomedical research that includes studies of animal diseases, diseases shared by humans and animals, and spontaneously occurring or experimental animal models of human disease. This proposal will address the critical need for veterinarians trained in biomedical research by supporting the research training of four outstanding veterinarians (per year) by a team of 33 well-funded faculty with strong research training records at a campus with a superb training environment, exceptional resources, and a historical commitment to graduate student research training.

PI_NAMEs: SURESH, MARULASIDDAPPA  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: comparative;Science;Training Programs

PROJECT_TITLE: Comparative Biomedical Sciences Training Program


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Palliative Care;Prevention;Primary Health Care;Rehabilitation;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PUBLIC HEALTH RELEVANCE The numbers of breast cancer survivors are increasing and their symptom burden after treatment is significant. Despite a growing evidence base of symptom management and risk reduction strategies, use of these activities in primary care practice remains suboptimal. This study engages critical stakeholders in identifying and prioritizing evidence based activities to enhance breast cancer survivorship care and has potential to impact implementation strategies used throughout the U.S. for long-term care for patients with a history of breast cancer.

PI_NAMEs: CRABTREE, BENJAMIN F;HUDSON, SHAWNA V. (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adopted;Adoption;Aftercare;American Cancer Society;Biological Response Modifier Therapy;Breast Cancer survivor;Breast Cancer survivorship;Breast Cancer Treatment;Cancer Model;Cancer Survivor;Cancer Survivorship;cancer survivorship care;Caring;chemotherapy;Chronic Disease;Clinical;Clinical Management;clinically actionable;Code;Complex;concept mapping;Consensus;Cost Analysis;Counseling;design;Development;Diagnosis;Diagnostic;Early Diagnosis;Early treatment;Education;Effectiveness;effectiveness trial;Evaluation;evidence base;experience;follow-up;Future;Guidelines;Health behavior;Healthcare;Healthcare Systems;hormone therapy;Hybrids;implementation strategy;implementation/effectiveness;Individual;Information Systems;innovation;Intervention;Interview;Knowledge;Learning;Literature;Long-Term Care;Long-Term Effects;Malignant Breast Neoplasm;Mental Health Services;Methods;Modeling;Monitor;multidisciplinary;Oncology;Patient Care;Patients;Policies;Policy Maker;Population;Positioning Attribute;Primary Care;primary care practice;primary care setting;Process;Protocols documentation;Provider;Public Advocacies;public health relevance;Radiation;Randomized;receptor;Recommendation;Recording of previous events;Recurrence;Research;Research Design;Research Personnel;research study;Risk Management;Risk Reduction;Second Primary Cancers;Self Management;Services;Site;Structure;survivorship;Symptom Burden;symptom management;Testing;Translating;translational potential;uptake;Waiting Lists;Work

PROJECT_TITLE: Adapting and implementing evidence-based breast cancer follow-up in primary care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Given the cost of child health and well-being problems related to ineffective parenting to individuals, families, and society, parenting interventions are arguably one of the best ways to broadly improve the health and well-being of the US population. With the proposed research, we will develop and test engagement-focused elements newly integrated into an evidence-based, widely disseminable, free Internet-based parenting program. Cracking the code of providing parents with free, easy to use interventions that they actually use and that improve parenting outcomes should have far-reaching beneficial effects.

PI_NAMEs: RHOADES, KIMBERLY A (contact)

PROJECT_TITLE: Optimizing an Evidence-Based, Disseminable, Free Internet-Based Parenting Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: NARRATIVE The proposed study is relevant to public health because understanding the underlying mechanisms that regulate bone formation in response to loading during normal physical activity and exercise will form the basis for developing novel therapeutic targets to prevent bone loss and reduce fracture risk in our aging population. As a result, this study aligns well with the NIH mission of developing strategies for the prevention of osteoporotic fractures and improving the health and well-being of older adults.

PI_NAMEs: GARDINIER, JOSEPH DANIEL (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Actins;Adult;Age-Related Bone Loss;aging population;Animal Model;antagonist;bone;bone loss;bone mass;Bone Tissue;Calcium Signaling;Cell Line;Cells;Clinical;cofilin;conditional knockout;CRISPR/Cas technology;dentin matrix protein 1;Development;Economic Burden;efficacy evaluation;Engineering;Exercise;exercise prescription;experimental study;fluid flow;fracture risk;Gene Expression;Goals;Health;Health Care Costs;Hindlimb Suspension;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Knock-out;Knockout Mice;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;mechanical load;mechanical properties;mechanotransduction;Mission;Mus;Muscle;new therapeutic target;novel therapeutic intervention;novel therapeutics;Nucleotides;old mice;older adult;Osteocytes;Osteogenesis;Osteoporosis;Osteoporosis prevention;osteoporosis with pathological fracture;Outcome;overexpression;P2Y2 receptor;Paralysed;Personal Satisfaction;Phosphorylation;Physical activity;Physical Exercise;Play;Prevalence;prevent;Prevention strategy;protein expression;Public Health;Purinoceptor;response;Role;Series;Signal Transduction;Stress Fibers;Testing;Therapeutic;Therapeutic Agents;therapy design;Tissues;treadmill;United States National Institutes of Health

PROJECT_TITLE: Modifying the mechanotransduction of bone by targeting purinergic receptors

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Rehabilitation

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Posttraumatic stress disorder (PTSD) is a costly and debilitating public health concern, with high rates of comorbidity and suicidality. One promising complementary integrative health option is the provision of a service dog specifically trained to mitigate core symptoms of PTSD. Understanding how, why and for whom the PTSD service dog intervention is most efficacious is imperative to optimize refinement and maximize clinical impact.

PI_NAMEs: O'HAIRE, MARGUERITE ELIZABETH (contact)

PROJECT_TERMS: Acceleration;actigraphy;Address;Affect;alpha-amylase;Animals;arm;Arousal;Behavior assessment;biobehavior;biological adaptation to stress;Biological Markers;biopsychosocial;Blinded;Canis familiaris;Characteristics;Clinical;Clinical Practice Guideline;Clinical Trials;clinically significant;Collaborations;comorbidity;Complement;Complementary Health;Complementary therapies;completed suicide;Complex;Control Groups;cost;data streams;Diagnosis;Disease;distraction;Dose;Dropout;Ecological momentary assessment;Effectiveness;Effectiveness of Interventions;efficacy evaluation;efficacy trial;emotional experience;emotional functioning;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;Funding;General Population;Generalized Anxiety Disorder;Goals;Health;Heterogeneity;Human;Hydrocortisone;improved;Individual;Integrative Medicine;International;Intervention;Knowledge;Lighting;Major Depressive Disorder;Mediating;Mental Health;Methodology;military veteran;Monitor;multidisciplinary;multimodality;Outcome;Pathway interactions;Physical activity;Physiological;Physiology;Pilot Projects;Post-Traumatic Stress Disorders;Process;Provider;psychosocial;psychosocial rehabilitation;Public Health;Qualifying;randomized, clinical trials;rehabilitation strategy;Rehabilitation therapy;Research;Research Design;Research Personnel;response;Salivary;Scientific Advances and Accomplishments;Service animal;Site;Sleep;Social Facilitation;Social support;Standardization;Stress;Substance abuse problem;suicidal;suicide rate;Surveys;Symptoms;System;Temperament;Testing;theories;Therapeutic;Training;treatment effect;Treatment Efficacy;United States National Institutes of Health;usual care arm;Validation;Veterans;welfare;Work;wristband

PROJECT_TITLE: Multi-site, longitudinal trial evaluating the efficacy, mechanisms, and moderators of service dogs for military Veterans with PTSD


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Despite the significant burden and predicted future growth of trauma as a public health problem in Sub-Saharan Africa (SSA), there remains a gap in trauma research training and distinct limitations in quantitative offerings at institutions of higher education in the region. The proposed Sustainable Trauma Research and Mentorship (STREaM) program will train a cadre of multidisciplinary trainees at three educational levels (MPH, PhD, and post-doctoral) to create a critical mass of trauma researchers in Cameroon with knowledge of novel, cutting edge quantitative methodologies. STREaM’s team-mentoring approach aims to build capacity for public health investigators who are able to design, lead, implement and scale innovative, transdisciplinary interventions within Cameroon and the SSA region to improve trauma prevention and treatment outcomes.

PI_NAMEs: CHICHOM, ALAIN MEFIRE;HUBBARD, ALAN E;JUILLARD, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Africa South of the Sahara;California;Cameroon;Cause of Death;Clinical Sciences;Community of Practice;Country;Data;Data Collection;disability;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational process of instructing;evidence base;Faculty;Foundations;Healthcare;implementation science;improved;Income;Infrastructure;Injury;injury burden;injury prevention;innovation;International;Machine Learning;Mentors;Mentorship;Methods;multidisciplinary;Nature;next generation;novel;online course;Pathway interactions;Persons;Play;Policies;Positioning Attribute;Postdoctoral Fellow;Prevention;programs;Reporting;Research;Research Infrastructure;Research Methodology;Role;San Francisco;Scientist;skills;Stream;Students;Time;tool;Training;training opportunity;Translational Research;Trauma;trauma care;Trauma Research;Universities;Vulnerable Populations

PROJECT_TITLE: Strengthening the Quantitative Pipeline for Multidisciplinary Trauma Research in Cameroon


ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Metabolic stress is considered a major factor in the development of menstrual cycle disorders, amenorrhea and infertility in females. Using genetic, pharmacologic and molecular approaches, this proposal tests the hypothesis that a brainstem – hypothalamic neural pathway mediates the effect of chronic undernutrition on ovarian cyclicity in females. Results from this proposal will contribute enhanced understanding that may influence the management and treatment for anovulatory disorders resulting from negative energy balance.

PI_NAMEs: CHURCH, KELLIE BREEN (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Acute;Amenorrhea;Anatomy;Animal Model;anovulatory disorder;antagonist;Antimetabolites;biological adaptation to stress;Brain Stem;Catecholamines;Cells;Chronic;Corticotropin-Releasing Hormone Receptors;Coupling;Data;Deoxyglucose;designer receptors exclusively activated by designer drugs;Development;Disease;energy balance;Equilibrium;Estradiol;Estrus;Female;Fertility;FOS gene;Foundations;Functional disorder;functional hypothalamic amenorrhea;Generations;Genetic;Glucose;GNRH1 gene;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Hormone secretion;Hypothalamic structure;Impairment;Infertility;KISS1 gene;knock-down;Knock-out;knowledge integration;Luteinizing Hormone;Malnutrition;Mediating;Mediator;Menstruation Disturbances;Metabolic;Metabolic Control;Metabolic stress;Methods;Molecular;Mus;neural;Neural Pathways;neuromechanism;Neurons;Neuropeptides;Neurosecretory Systems;neurotransmission;Norepinephrine;novel;Ovarian;Ovarian Cycles;paraventricular nucleus;Pathway interactions;Periodicity;pharmacologic;Physiologic pulse;Physiological;Population;prevent;Process;Production;receptor;Regulation;Reproduction;reproductive;reproductive function;Research;Research Personnel;response;Role;Signal Transduction;Stress;Talents;Testing;tool;Transgenic Mice;Transgenic Organisms;urocortin;Ventricular;Woman;Work

PROJECT_TITLE: Regulation of gonadotropin secretion during undernutrition by a brainstem-hypothalamic neural pathway

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative An important aspect of type 2 diabetes (DMII) care is the control of co-morbid cardiovascular disease (CVD) risk factors, including hypertension (HTN), to reduce morbidity and mortality. Yet only half of adults with diabetes achieve recommended blood pressure targets; these disparities are more pronounced in South Asians immigrants (persons with ancestry from India, Bangladesh, or Pakistan or other parts of the South Asian continent). The proposed project provides a unique opportunity to address this public health challenge by bringing together clinics and community partner across the northeastern and southeastern US to test the effectiveness and implementation process of a telehealth-based CHW-led coaching intervention for HTN control among 450 South Asian patients with co-morbid DMII and HTN.

PI_NAMEs: ISLAM, NADIA S (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;Area;Asian Americans;Asian population;Attention;Bangladesh;Blood Pressure;blood pressure control;blood pressure reduction;burden of chronic illness;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Cities;Clinic;Clinical;Collaborations;Communities;community clinical linkage;Community Health;Community Health Aides;community living;community organizations;community partners;Community Services;community setting;comorbidity;comparison intervention;Consolidated Framework for Implementation Research;contextual factors;County;COVID-19 pandemic;diabetes management;Diabetes Mellitus;Diffusion;disease disparity;Disease Outcome;Disparity;Effectiveness;effectiveness evaluation;effectiveness testing;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;experience;Fostering;Geographic Locations;Glycosylated hemoglobin A;Goals;Growth;health care availability;health care settings;Health education;Health Sciences;Health Services;high risk population;hybrid type 1 trial;Hypertension;hypertension control;Immigrant;Immigrant community;Immigration;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation science;improved;India;Individual;innovation;Institution;Intervention;Limited English Proficiency;Linguistics;Long Island;Maintenance;medical schools;Minority Groups;Modeling;Morbidity - disease rate;mortality;Multilingualism;New England;New York City;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Pakistan;Patients;Pattern;Persons;Population;Poverty;primary care practice;primary care setting;primary outcome;programs;Public Health;racial minority population;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Resources;Risk Factors;Science;secondary outcome;Self Efficacy;Site;social;Social Work;South Asian;Southeastern United States;stroke risk;suburb;telehealth;Testing;therapy design;Training;treatment arm;treatment as usual;trial design;United States;United States National Institutes of Health;urban area;Vulnerable Populations;Weight;Work

PROJECT_TITLE: Scaling Telehealth Models to Improve Co-morbid Diabetes and Hypertension in Immigrant Populations

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Cellular therapies, such as CD19-directed chimeric antigen receptor T-cells (CAR-T), are at the forefront of large B-cell lymphoma (LBCL) treatment, but the majority of treated patients will ultimately experience disease recurrence or progression. This multidisciplinary study aims to better understand why CAR-T therapy sometimes fails, despite very promising results in some patients. We seek to understand how tumor genomic composition drives resistance to CAR-T and will synthesize clinical, molecular, and imaging data using computational tools to predict the likelihood of response to CAR-T and to identify biomarkers to personalize patient care.

PI_NAMEs: SHOUVAL, RONI  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: acquired treatment resistance;Address;Antigens;Autologous;Automobile Driving;B-Cell Lymphomas;BCL2 gene;biobank;Bioinformatics;Biological Markers;Biology;biomarker discovery;biomarker identification;Biopsy;cancer cell;CAR T cell therapy;CD19 gene;Cell Death Induction;Cell Therapy;Cells;Cessation of life;chimeric antigen receptor T cells;Clinical;clinical decision-making;Code;cohort;combinatorial;Complement;computer infrastructure;computerized tools;cytotoxic;cytotoxicity;Data;Decision Support Systems;Disease;DNA Sequence Alteration;experience;Flow Cytometry;Genes;Genetic;genomic biomarker;Genomics;Genotype;Goals;Heterogeneity;high risk;Image;Immune;Immune checkpoint inhibitor;Immunology;Immunooncology;Immunotherapy;improved;Individual;individual patient;Inflammatory;Interferon Type II;interpatient variability;Knowledge;Laboratories;Lymphoma;Machine Learning;machine learning algorithm;Malignant Neoplasms;Measures;Mediating;Medical Imaging;Mentorship;Methodology;Modality;Modeling;Molecular;multidisciplinary;multimodal data;multimodal modeling;multimodality;multiple data sources;multiple omics;Mutation;new therapeutic target;novel;novel marker;Outcome;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;personalized approach;personalized care;personalized medicine;Phenotype;predicting response;predictive marker;predictive modeling;pressure;Prognostic Factor;Prognostic Marker;Publishing;radiological imaging;Radiology Specialty;radiomics;Receptor Signaling;Recurrent disease;Refractory;Relapse;Resistance;resistance mechanism;response;Risk;Role;Sampling;Shapes;Signal Transduction;Stimulus;success;therapy resistant;TP53 gene;transcriptomic profiling;transmission process;Treatment Efficacy;Treatment Failure;tumor;Tumor Burden;Work

PROJECT_TITLE: A multimodal approach for precision immuno-oncology in lymphoma treated with CAR-T cells

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Heart failure is a major barrier to healthy aging among women with HIV in sub-Saharan Africa, but most research on the early pathogenesis of HIV-related heart muscle disease has been conducted among mostly male populations in high income countries. The overarching goal of our proposed study is to characterize mechanisms of HIV-associated myocardial fibrosis and steatosis among women in sub-Saharan Africa using advanced cardiac magnetic resonance imaging. Understanding sex- and region-specific drivers of myocardial fibrosis and steatosis will facilitate development of prevention strategies relevant to 13 million women with HIV in sub-Saharan Africa, which represents >2/3 of all women with HIV globally.

PI_NAMEs: LONGENECKER, CHRIS TODD (contact);NTUSI, NTOBEKO AYANDA BUBELE;ZANNI, MARKELLA V.

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Acceleration;Africa South of the Sahara;Aging;antagonist;Anti-Retroviral Agents;Biological Markers;Cardiac;cardiac magnetic resonance imaging;cardiac muscle disease;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;CCR5 gene;Cells;Characteristics;Chronic;Cicatrix;Clinical;co-infection;cohort;coronary fibrosis;Country;Cytomegalovirus;Death Rate;design;Development;diet and exercise;Diffuse;Estrogens;exercise intervention;experience;Exposure to;extracellular;Fatty acid glycerol esters;Fibrosis;fine particles;Flow Cytometry;follow-up;Functional disorder;Funding;Future;Geography;Goals;healthy aging;Heart failure;HIV;HIV Infections;Hormonal;imaging study;Imaging Techniques;Immune;immune activation;Immunologic Factors;Immunologics;Income;indexing;Inflammation;Inflammatory;innovation;Integrase Inhibitors;interstitial;Investigation;lipidomics;Magnetic Resonance;Magnetic Resonance Imaging;male;men;Menopause;Metabolic;metabolic phenotype;metabolomics;mullerian-inhibiting hormone;Myocardial;Myocardial tissue;National Heart, Lung, and Blood Institute;novel;Obesity;osteopontin;Outcome;ovarian reserve;Pathogenesis;Pathologic Processes;Pathway interactions;Persons;Phenotype;Play;Population;Populations at Risk;Positioning Attribute;preservation;prevent;Prevention strategy;preventive intervention;Production;Recording of previous events;recruit;reproductive senescence;Research;Research Design;Risk;Risk Factors;sex;Site;South Africa;Spectrum Analysis;sudden cardiac death;Techniques;Therapeutic;transdermal estrogen;Triglycerides;Tuberculosis;Uganda;Ventricular Arrhythmia;Viral;Visceral;Weight Gain;Woman;Women's mortality;women's treatment;Work

PROJECT_TITLE: Myocardial Fibrosis and Steatosis Burden and Region-Specific Predictors of Progression among ART-treated Women with HIV infection in sub-Saharan Africa (The MUTIMA Study)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Skin and musculoskeletal regenerative therapies for large and chronic wounds are limited by an incomplete understanding of proliferative regulation. This proposal investigates how highly regenerative mammals activate and maintain cell proliferation in the face of inhibitory conditions to drive regeneration. This work will generate novel targets for regenerative therapies and high throughput screening tools for evaluating phenotypes associated with regenerative ability.

PI_NAMEs: ALLEN, ROBYN S. (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adult;antifibrotic treatment;Candidate Disease Gene;candidate identification;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Density;Cell Proliferation;Cells;cellular transduction;chronic wound;Cicatrix;Complex;Contact Inhibition;Data;Data Set;Defect;density;Dependovirus;Dermal;Ear;Equilibrium;experimental study;Exposure to;external ear auricle;fascinate;Fibroblasts;Fibrosis;gamma irradiation;Gene Activation;Gene Expression;Genes;Gerbils;Growth;Healthcare Industry;high throughput screening;Human;In Vitro;in vitro Assay;in vivo;Injury;innovation;insight;knock-down;Lentivirus;Long term disability;Maintenance;Mammals;Medicine;model building;Modeling;Molecular;Mus;Musculoskeletal;Natural regeneration;non-healing wounds;novel;novel strategies;organ injury;organ repair;Oryctolagus cuniculus;Outcome;Oxidative Stress;Pathway interactions;Phenotype;Physiological;prevent;Process;programs;Proliferating;Proteins;Psychological Stress;Rattus;Reactive Oxygen Species;regenerative;regenerative approach;Regenerative Medicine;Regenerative response;regenerative therapy;Regulation;repaired;Reproducibility;Research;Resistance;Resolution;response;response to injury;Rodent;Role;screening;Screening procedure;senescence;sensor;Signal Pathway;Signal Transduction;skills;Skin;skin regeneration;skin wound;small hairpin RNA;Stress;System;targeted treatment;Testing;tissue regeneration;Tissues;tool;transcriptome sequencing;Work

PROJECT_TITLE: A multispecies system for elucidating proliferative control mechanisms during mammalian skin and musculoskeletal regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Environmental pollutants as well as plant, microbial and host-derived products can bind to aryl hydrocarbon receptors (AhR). Our studies will determine how dietary indoles bind to AhR and then elements in the DNA to produce anti-microbial peptides. These peptides can cause changes in gut microbiota and immunosuppression.

PI_NAMEs: NAGARKATTI, MITZI ;NAGARKATTI, PRAKASH S (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Anti-Inflammatory Agents;anti-microbial peptide;Antiinflammatory Effect;ARNT gene;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;ATAC-seq;Attenuated;beta-Defensins;Binding;Biological Assay;Broccoli - dietary;Cabbage - dietary;Cauliflower;CD4 Positive T Lymphocytes;Cells;Chromatin;chromatin remodeling;Chronic;Clinical;Colitis;Colon;Colonic inflammation;comparison control;Complex;Crohn's disease;Data;Defensins;dextran sulfate sodium induced colitis;Dietary Factors;Dietary Indole;Dietary Phytochemical;Dioxins;Disease;disease model;DNA;DNA Methylation;Electrophoretic Mobility Shift Assay;Elements;Environmental Pollutants;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;FOXP3 gene;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;gut dysbiosis;gut microbiota;Histone Acetylation;Histone Deacetylase Inhibitor;Histone Deacetylation;histone modification;Human;IL17 gene;Immune response;Immune system;Immunomodulators;immunoregulation;Immunosuppression;Indole-3-Carbinol;Inflammation;Inflammatory Bowel Diseases;intestinal barrier;intestinal epithelium;Intestines;Knockout Mice;Ligands;Ligation;Mediating;microbial;microbial colonization;microbial products;microbiota;MicroRNAs;Modeling;murine colitis;Mus;novel;Pathogenesis;Pathway interactions;Patients;Peptides;Persons;Plants;Play;pollutant;prevent;Prevention;promoter;Property;Protein Family;Quantitative Reverse Transcriptase PCR;Receptor Activation;Regulation;Regulatory T-Lymphocyte;Reporter;Resistance;Response Elements;Role;sensor;Surface;T cell differentiation;T-Lymphocyte;Testing;Tissues;transcription factor;trinitrobenzene sulfonic acid induced colitis;Ulcerative Colitis;villin

PROJECT_TITLE: Role of the environmental sensor, AhR on colitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Enzymes and coenzymes enable almost all metabolic transformations within organisms. For this reason, knowledge of enzymes often plays a key role in the amelioration of diseases, both infectious and non- infectious. A major focus of enzymologists is to understand enzymatic transformations, in terms of both mechanism and cellular context, to treat and/or cure specific diseases. How these processes occur and what can be done to manipulate them to improve human health are central topics of our meeting.

PI_NAMEs: SOBRADO, PABLO ;TAYLOR, ERIKA A (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Academia;Appointment;Area;Biochemical Reaction;Biochemistry;Biological Process;Biological Sciences;Biology;biophysical chemistry;Biophysics;career;Chemicals;Coenzymes;Collaborations;Communication;Communities;Development;Diagnosis;Discipline;Disease;drug discovery;Ensure;Environment;Enzymatic Biochemistry;Enzymes;Enzymes and Coenzymes;ethnic minority;Ethnic Origin;experience;Faculty;Fostering;Functional disorder;Funding;Gender;Gene Expression Regulation;Goals;graduate student;Health;Human;improved;Industrialization;Industry;infectious disease treatment;Institution;intergenerational;Knowledge;Life;Malaria;Malignant Neoplasms;meetings;Metabolic;Metabolic Pathway;Metabolism;method development;Methodology;Methods;microbial;Molecular Biology;Nationalities;Nerve Degeneration;Nervous System Disorder;Neurosciences;novel therapeutics;Oral;Organism;Outcome;Participant;peer;Peripheral;Pharmaceutical Chemistry;Phosphorylation;Play;Positioning Attribute;Postdoctoral Fellow;posters;Process;professor;programs;Recording of previous events;recruit;Research;Research Personnel;Resort;Role;Running;Schedule;Science;Scientist;Seasons;Structure;Students;success;symposium;Underrepresented Populations;underserved community;Vision;Woman

PROJECT_TITLE: 2024 Enzymes, Coenzymes and Metabolic Pathways Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Cardiovascular;Hematology

PHR: Project Narrative The 2024 Hemostasis Gordon Research Seminar and Conference enjoys an international reputation for being the primary forum at which new advances in the field of thrombosis and hemostasis are unveiled and discussed. This meeting brings together young, emerging, and established investigators whose research focuses on both normal blood clotting and bleeding as well as diseases that promote clotting in many human diseases.

PI_NAMEs: AREPALLY, GOWTHAMI M (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Address;Ally;Applied Research;Area;Back;Basic Science;Binding;Biochemical;Biochemistry;Biology;Biotechnology;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Cardiovascular system;career;Cessation of life;Clinical;clinical investigation;Clinical Medicine;Clinical Research;Coagulation Process;Collaborations;Communities;cost;COVID-19 pandemic;COVID-19 vaccine;Dedications;Development;Diabetes Mellitus;Diagnostic;disability;Discipline;Disease;empowerment;Ensure;equity, diversity, and inclusion;experience;Exposure to;Faculty;Female;Fostering;Foundations;frontier;Future;Genetic;Goals;Health;Hemorrhage;Hemostatic Agents;Hemostatic Disorders;Hemostatic function;Home;Human;human disease;improved;In Vitro;in vivo Model;Industry;Inequity;Infection;Inflammation;innovation;Institution;interest;International;Intervention;Knowledge;Leadership;Malignant Neoplasms;Medical;meetings;Mission;Modeling;Motion;National Heart, Lung, and Blood Institute;novel therapeutics;Obesity;Oral;pandemic disease;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;posters;Productivity;programs;Proteins;Race;Regulation;Research;Research Personnel;Running;Science;Scientist;Seminal;Sepsis;Series;stem;Structure;success;symposium;System;Talents;Thrombosis;thrombotic complications;tool;Training;Translating;Trauma;Travel;Underrepresented Minority;United States;unpublished works;Washington;Work

PROJECT_TITLE: 2024 Hemostasis Gordon Research Conference and Gordon ResearchSeminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative  Submucous cleft palate (SMCP) is a common craniofacial birth defect that causes feeding difficulties, middle ear dysfunction leading to hearing loss, and speech problems. SMCP is due to abnormal attachment of the palatal muscles, of which surgical repair is challenging and often could not restore normal function for swallowing and speech. Using novel mouse models and innovative research approaches, this project will uncover the underlying developmental and molecular mechanisms and lead to significant improvement in diagnosis, counseling, and treatment of SMCP and other craniofacial malformations.

PI_NAMEs: JIANG, RULANG  (contact);LAN, YU

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;Air;aponeurosis;autosome;Biological Assay;Birth;Breathing;Cell Communication;cell type;Cells;Cephalic;Cleft Palate;Congenital Abnormality;Connective Tissue;Connective Tissue Cells;connective tissue development;Counseling;craniofacial;Craniofacial Abnormalities;craniofacial disorder;Data;Defect;Deglutition;Development;Developmental Biology;Diagnosis;Disorientation;Embryo;Etiology;Exhibits;experimental study;Failure;feeding;Food;Functional disorder;Genetic Markers;Hard Palate;hearing impairment;Heterozygote;Human;improved;innovation;intercellular communication;Lateral;Limb structure;Liquid substance;Maps;Medial;Mediating;Mesenchymal Stem Cells;Mesenchyme;Mesoderm;middle ear;migration;Missense Mutation;Molecular;molecular marker;Morphogenesis;mouse model;Mus;Muscle;Muscle Development;muscle form;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;mutant;Mutant Strains Mice;myogenesis;Neural Crest Cell;novel;Operative Surgical Procedures;Oral mucous membrane structure;Oropharyngeal;Outcome;Palatal Muscles;Palate;Palate Bone;Pathway interactions;Pattern;Pharyngeal structure;Regulation;repaired;Research;Resources;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Soft Palate;Source;Specific qualifier value;Speech;stem cell population;Structure of mucous membrane of nose;Study models;Techniques;tendon development;Tendon structure;Testing;Tissue Differentiation;Tissue Embedding;tissue regeneration;Tissues;transcription factor;transcriptomics

PROJECT_TITLE: Molecular Regulation of Palate Development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Drug Abuse (NIDA only);Microbiome;Neurosciences;Opioids;Pain Research;Pediatric;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative There is a strong correlation between early opioid use and increased susceptibility to opioid use and associated comorbidities later in life. Particularly, in preclinical models, long-term consequences of neonatal morphine exposure (NME) include pain hypersensitivity persisting later in life as well as a persisting dysbiotic gut microbiome. This proposal postulates that NME-induced gut dysbiosis results in microglial activation and sustained neuroinflammation, which drives the prolonged hypersensitivity observed following NME.

PI_NAMEs: ANTOINE, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;Adolescence;Adolescent;Adult;Affect;Age;Animal Model;antagonist;Antibodies;Attenuated;Automobile Driving;Bacterial Translocation;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Central Nervous System;Chronic;Clinical Research;comorbidity;Complex;CSF1R gene;Data;Development;dysbiosis;early childhood;Event;experimental study;Exposure to;fecal transplantation;Functional disorder;Genetic;glial activation;Goals;gut dysbiosis;gut microbiome;Hyperalgesia;Hypersensitivity;Immune;immune function;Immune response;immunocytochemistry;Immunohistochemistry;Inflammation;Inflammatory;Inflammatory Response;Intervention;intestinal barrier;Life;Long-Term Effects;Maintenance;Mediating;Mediator;Messenger RNA;microbial;microbiome;Microglia;midbrain central gray substance;Midbrain structure;Molecular;Morphine;Morphology;Mother-Child Relations;mouse model;Mus;Neonatal;Neonatal Intensive Care Units;neonatal period;neonate;Nervous System;neural circuit;neuroinflammation;Nociception;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid exposure;opioid use;Pain;Pain management;pain sensitivity;Pathologic;polysubstance use;Population;postnatal;Pre-Clinical Model;Predisposition;prevent;Prevention Guidelines;probiotic therapy;Probiotics;Procedures;Protein Array;Rodent;Rodent Model;Role;Running;Sensory;side effect;Spinal Cord;systemic inflammatory response;Testing;Therapeutic;Tissues;tool

PROJECT_TITLE: Role of the gut microbiome in prolonged pain hypersensitivity following neonatal morphine exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE The proposed study will explore the intergenerational effect of Hispanic caregivers’ childhood trauma on their sexual minority youth’s depressive symptoms and the mechanisms through which this relationship may exist, such as communication quality and acculturation discrepancies between caregivers and their adolescents. Understanding these relationships offers opportunities to inform family-based interventions focused on preventing and reducing depressive symptoms in a population experiencing mental health disparities. This award will support my development toward becoming an independent nurse scientist dedicated to improving mental health equity through family-based interventions for Hispanic sexual minority youth.

PI_NAMEs: SCOTT, DALTON  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Academy;Acculturation;Adolescent;adolescent mental health;adverse childhood events;Affect;Age;American;Area;Award;Caregivers;Caring;Characteristics;Communication;Data;data harmonization;Dedications;depressive symptoms;Development;Disparity;Emergency Situation;emotional neglect;ethnic identity;ethnic minority;experience;Family;Foundations;Funding;Goals;Growth and Development function;Health;health disparity;health equity;Heterosexuals;Hispanic;Hispanic Populations;improved;Individual;innovation;intergenerational;Intervention;Knowledge;Literature;longitudinal analysis;longitudinal dataset;marginalization;Measures;Mediating;Mediation;Mediator;Mental Health;Mentorship;method development;Minority;minority children;National Research Service Awards;Not Hispanic or Latino;Nurses;Outcome;Participant;Pathway interactions;pediatric trauma;Pediatrics;Perception;Pilot Projects;Population;prevent;Qualitative Methods;Reporting;Research;Role;Science;Scientist;Sex Orientation;Sexual abuse;sexual identity;sexual minority;sexual minority youth;skills;statistics;Strategic Planning;Subgroup;Testing;theories;therapy development;Training;Trauma;United States National Institutes of Health;Youth

PROJECT_TITLE: Intergenerational and Cultural Drivers of Depressive Symptoms in Hispanic Sexual Minority Youth

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) causes debilitating wandering symptoms, as well as memory loss. Dysfunction of the retrosplenial cortex (RSC) is apparent in the earliest stages of AD, but the neural circuit impairments underlying these dysfunctions remain unknown. This study will mechanistically explore how key retrosplenial circuits underlying navigation progressively become impaired in two preclinical models of AD, providing valuable insight into the pathogenesis of AD and potentially identifying novel therapeutic targets.

PI_NAMEs: RYBICKI-KLER, CHLOE ISABELLA (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Anatomy;Anterior;Anterograde Amnesia;basal forebrain;Behavior;biophysical analysis;Brain region;cell cortex;cell type;Cells;cholinergic;Data;Disorientation;Dissection;Elements;Environment;Female;Functional disorder;Genetic Models;Head;hippocampal pyramidal neuron;Impairment;insight;Knowledge;Lesion;male;Maps;Memory impairment;Memory Loss;mouse model;Mus;neural circuit;Neurofibrillary Tangles;Neurons;new therapeutic target;optogenetics;Pathogenesis;Persons;Pharmacology;Physiological;Physiology;pre-clinical;Pre-Clinical Model;Pyramidal Cells;Resistance;Source;Space Perception;spatial memory;Symptoms;Synapses;Testing;Thalamic structure;Therapeutic;way finding;Width;Work

PROJECT_TITLE: Cell-type-specific dissection of retrosplenial circuits in preclinical models of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]