NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: • The behavioral treatment of choice for obsessive-compulsive disorder (OCD) is exposure and response  prevention (ERP), which depends on safety learning processes and large-scale brain networks that are  aberrant in OCD. • The proposed project would be among the first to characterize neural functions associated with safety  learning and memory deficits in OCD. • The target engagement aim of the proposed project would test the effects of frontopolar multifocal  transcranial direct current stimulation (tDCS) on functional connectivity and functional activation of the  default mode network (DMN) and salience network (SN) and on fearful responding during extinction  training in patients with OCD.

PI_NAMEs: ADAMS, THOMAS G (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Adult;Anodes;Anterior;anxious;Behavior Therapy;Brain;brain circuitry;cingulate cortex;Clinical;Clinical Trials;Cognitive Therapy;Communities;conditioned fear;conditioning;Data;design;Diagnosis;Double-Blind Method;Expectancy;experimental study;Exposure to;Extinction;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Galvanic Skin Response;Genetic Complementation Test;in vivo;innovation;Insula of Reil;Investigational Therapies;Learning;learning extinction;Literature;long term memory;Measures;Medial;Memory impairment;memory process;Methods;neural;Neurophysiology - biologic function;Obsessive-Compulsive Disorder;Participant;Patients;Pattern;Persons;Post-Traumatic Stress Disorders;Prefrontal Cortex;Prevention;Procedures;Process;Psychopathology;Psychotherapy;Randomized;Recovery;Reinforcement Schedule;Reporting;Research;response;Rest;Safety;Sampling;Scanning;screening;Shock;signal processing;Signal Transduction;Standardization;Stimulus;Symptoms;Testing;Therapeutic;therapeutic target;Training;transcranial direct current stimulation;treatment choice;treatment responders;volunteer

PROJECT_TITLE: Characterization and Modulation of Functional Connectivity and Fear Extinction Abnormalities in Obsessive-Compulsive Disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Cannabinoid Research;Crohn's Disease;Digestive Diseases;Emerging Infectious Diseases;Endocannabinoid System Research;Foodborne Illness;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The potential for enteric pathogens to proliferate within the gut is dependent on the reduction or complete loss of colonization resistance. This proposal will define how the endocannabinoid system can lower colonization resistance in the gut, thus enhancing pathogen colonization and exacerbating gut inflammation. Understanding how this occurs is critical for developing therapeutic strategies that harness the putative beneficial effects of the endocannabinoid system, while also preventing adverse effects that may arise from decreased colonization resistance and gut microbiome dysfunction.

PI_NAMEs: ELLERMANN, MELISSA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 16S ribosomal RNA sequencing;2-arachidonylglycerol;Adherent Invasive Escherichia coli;Adverse effects;Anabolism;appetite loss;bacterial genetics;Behavior;cannabinoid receptor;Chronic Disease;chronic inflammatory disease;Citrobacter rodentium;Clinical Research;CNR1 gene;cofactor;Colitis;colonization resistance;common symptom;Crohn's disease;Data;debilitating symptom;Development;Disease;disease model;Disease remission;disorder risk;Ecological Change;Ecology;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;enteric infection;enteric pathogen;Enterobacteriaceae;Enterobacteriaceae Infections;enteropathogenic Escherichia coli;Environmental Risk Factor;Enzymes;Escherichia coli;Escherichia coli EHEC;Escherichia coli Infections;Foundations;Functional disorder;Gene Expression Profiling;Genetic;Growth;gut colonization;gut inflammation;gut microbiome;Hormones;host microbiota;human model;Individual;Infection;Infectious colitis;Inflammation;innovation;Invaded;Ligands;Link;Lipids;Metabolic Pathway;Metabolism;metabolomics;microbial;microbiome;microbiome alteration;microbiome composition;Molybdenum;Monoacylglycerol Lipases;mouse model;Mucous Membrane;Mus;Nitrates;novel;Nutrient;Pain;pathobiont;pathogen;Pathogenesis;Pathway interactions;pharmacologic;Physiological;Predisposition;prevent;Proliferating;receptor;Reporting;Respiration;response;Signal Transduction;symptom management;Testing;Therapeutic;therapeutic target;Tissues

PROJECT_TITLE: Effects of host endocannabinoid signaling on Enterobacteriaceae infection

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This proposal combines advanced pattern analysis applied to magnetic resonance imaging with integrative omics analysis to enhance understanding of the disease biology of white matter hyperintensities (WMH), a common age-related imaging finding indicative of poor brain health. We will leverage novel machine learning-derived spatial patterns representing unique causes of WMH to improve prediction of related clinical outcomes including stroke and cognitive impairment on an individual basis, discover new genes relevant to WMH, and identify potential drug targets to advance development of mechanism-based therapies.

PI_NAMEs: PHUAH, CHIA-LING  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Address;Advanced Development;age related;aging population;aging related disease;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Amyloid;Attenuated;biobank;Biological;Biological Markers;Biology;Blood Vessels;Brain;Brain Diseases;brain health;Brain hemorrhage;Cardiovascular Diseases;causal variant;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Characteristics;Classification;Clinical;clinical translation;clinically significant;cohort;Cohort Studies;Communities;Coronary Artery Risk Development in Young Adults Study;Data;data resource;Databases;deep learning;Dementia;Development;Disease;disorder risk;disorder subtype;drug candidate;drug discovery;drug repurposing;Drug Targeting;Drug usage;endophenotype;Environmental Risk Factor;Ethnic Origin;Etiology;Evaluation;experimental study;Functional disorder;General Population;Genes;Genetic;genetic information;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomics;Genotype;Health;Heritability;Heterogeneity;High Prevalence;hypertensive;Image;Impaired cognition;improved;Individual;Informatics;insight;Intervention;Ischemic Stroke;Knowledge;Lesion;Liquid substance;Lobar;Location;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;Maps;Mendelian randomization;Meta-Analysis;Methods;middle age;Modeling;Molecular;MRI Scans;multimodality;multiple omics;Nature;neuroimaging;neuroinflammation;Neurologic;new therapeutic target;normal aging;novel;older adult;Outcome;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Pattern;personalized care;personalized diagnostics;Persons;Pharmaceutical Preparations;Phenotype;population based;Prevalence;Prevention;Prevention strategy;Prevention trial;Probability;Process;Proteins;Proteome;Quantitative Trait Loci;Race;Recovery;Reproducibility;Risk Factors;Role;Sampling;Sequence Analysis;Severities;Spatial Distribution;Stroke;stroke outcome;stroke risk;Testing;Therapeutic;therapeutic target;Tissues;trait;transcriptome;Validation;Variant;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: An Integrative Computational Multimodal approach to disentangle Pathophysiologic Heterogeneity of age-related White Matter Hyperintensities

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Primary open-angle glaucoma (POAG) is an intraocular pressure-related, chronic optic neuropathy that produces visual disability of public health importance. We will submit plasma collected before POAG diagnosis to state-of-the-art proteomic and metabolomic platforms. The biomarker data generated will be combined with genomic markers to gain insight into POAG etiology.

PI_NAMEs: KANG, JAE H;PASQUALE, LOUIS ROBERT (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: antibody mimetics;aptamer;artificial intelligence algorithm;Binding Proteins;biobank;Biological;Biological Assay;Biological Markers;biomarker signature;Blindness;Blood Vessels;Caring;case control;Categories;Characteristics;Chronic;Classification;Clinical;Clinical Data;clinical phenotype;clinically relevant;cohort;Control Groups;Data;Degenerative Disorder;Diagnosis;Diagnostic;Disease;disorder prevention;Ear;Endothelium;Etiology;Eye;follow-up;Follow-Up Studies;functional disability;Functional disorder;Genetic;genetic architecture;Genetic Predisposition to Disease;genomic biomarker;Genomics;Genotype;Glaucoma;Goals;Health Professional;High Density Lipoproteins;high risk;Hypertriglyceridemia;Immune;Immune response;innovation;insight;interest;Ketone Bodies;Knowledge;Lead;Lipid A;lipid metabolism;Lipids;Lipoproteins;liquid chromatography mass spectrometry;liquid chromatography mass spectroscopy;Low-Density Lipoproteins;Magnetism;Medicine;metabolomics;modifiable risk;Molecular Weight;multidisciplinary;Multiomic Data;multiple omics;Nerve Degeneration;Nitric Oxide;novel;Nuclear;Nurses' Health Study;Onset of illness;Open-Angle Glaucoma;Optic Nerve;optic nerve disorder;Participant;Particle Size;Pathway interactions;Pattern;Phase;phenotypic data;Physiologic Intraocular Pressure;Plasma;polygenic risk score;pre-clinical;Prevention;Primary Open Angle Glaucoma;prospective;Prospective cohort;Proteins;Proteome;proteomic signature;Proteomics;Public Health;Questionnaires;Reagent;repository;resilience;resilience biomarker;Resources;response;Risk;Risk Factors;Role;Sampling;secondary analysis;Signal Transduction;Specific qualifier value;Strategic Planning;Testing;Vascular Diseases;Visual;Visual disability;Visual Fields

PROJECT_TITLE: Multiomic Framework for Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Emergency Care;Neurosciences;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative In this proposal we will study a new synthetic blood substitute that is designed to open dormant blood vessels deliver oxygen to regions of the brain affected by a stroke. This will not only keep the brain cells from dying but also reduce the paradoxical disability from injury induced by successful removal of the clot (i.e. reperfusion injury). This a new drug and requires study in a controlled experiment with advanced imaging to better understand its method of action but has the potential to dramatically change the way people with stroke are treated.

PI_NAMEs: CARROLL, TIMOTHY J (contact);CHRISTOFORIDIS, GREGORY

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Affect;Aging;Ambulances;Anemia;Animal Model;Animals;Antiinflammatory Effect;Area;Biological Markers;Biological Products;Blood;Blood flow;blood product;Blood Substitutes;Blood Vessels;Brain;brain cell;Brain Hypoxia-Ischemia;Brain Infarction;Brain Injuries;Brain region;canine model;Carbon Monoxide;Carboxyhemoglobin;Cattle;Cells;Central venous pressure;Cerebral Hypoxia;Cerebral Infarction;Cerebrovascular Circulation;Cerebrum;Clinical Trials;Coagulation Process;comparison control;Complex;design;Developed Countries;Development;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disease;Dose;Edema;Effectiveness;efficacy evaluation;Embolectomy;Encephalitis;Excision;experimental study;extracellular;feeding;Fibrinolytic Agents;Functional disorder;Future;Generations;Goals;Growth;Hemoglobin;Hospitals;Human;Hypoxia;Image;improved;improved outcome;Infarction;Inflammation;Infusion procedures;Injury;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Leptomeninges;Magnetic Resonance Imaging;Measures;Methods;Microspheres;middle cerebral artery;Middle Cerebral Artery Occlusion;Misonidazole;Modeling;Natural History;Needles;Neurons;Neuroprotective Agents;Neutrons;next generation;Nitric Oxide;novel;novel therapeutics;Outcome;Oxygen;Partial Pressure;Patients;Perfusion;Persons;Pharmacologic Substance;Population;Positron-Emission Tomography;pre-clinical;preservation;prevent;Procedures;Process;recruit;Reperfusion Injury;Reperfusion Therapy;Roentgen Rays;Safety;Satellite Hospitals;serial imaging;side effect;Stroke;stroke model;stroke therapy;Symptoms;System;Testing;Time;Tissues;treatment effect;Triage;vasoconstriction;Vasodilation;vasogenic edema;Work

PROJECT_TITLE: Mitigation of Cerebral Infarct Growth in Acute Ischemic Stroke Using a Novel Blood Substitute

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Selective expression of XBP1 in the unfolded protein response IRE1 pathway has been shown to be effective against multiple neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases. The major goal of this project is to characterize the mechanism of action and improve the in vitro potency and specificity and in vivo pharmacological properties of a novel molecular glue activator of IRE1, Rapireon, that selectively activates the nuclease activity of IRE1, leading to splicing and activation of latent XBP1.

PI_NAMEs: LIU, JUN O. (contact);PAAVILAINEN, VILLE OSKARI

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Affect;Agonist;Alzheimer's Disease;Alzheimer's disease model;analog;Antineoplastic Agents;ATF6 gene;Biochemical;Biological Availability;Brain;Cell model;Cellular Assay;Complex;Cryoelectron Microscopy;Crystallization;Data;Data Collection;Data Set;deep sequencing;design;Disease;disease model;DNA;Drug Kinetics;Evaluation;Future;Genetic;Glues;Goals;Health;improved;In Vitro;in vivo;inhibitor;Investigation;iterative design;Lead;lead optimization;Learning;Libraries;Ligation;Luciferases;Malignant Neoplasms;Modeling;Molecular;Names;Nerve Degeneration;Neurodegenerative Disorders;novel;novel lead compound;nuclease;Parkinson Disease;Pathway interactions;Penetration;pharmacologic;Phase;Phosphotransferases;Play;Property;Proteins;rational design;recruit;Reporter;Resolution;response;Ribonucleases;RNA Splicing;Roentgen Rays;Role;screening;selective expression;sequencing platform;Signal Pathway;Sirolimus;Specificity;stoichiometry;structural biology;Structural Models;Structure;System;Tacrolimus Binding Protein 1A;Tacrolimus Binding Proteins;tool;transgene expression;X-Ray Crystallography;XBP1 gene

PROJECT_TITLE: Rapireon, a new macrocycle molecular glue that selectively activates the nuclease activity of IRE1

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Twenty six million people in the United States are limited English proficient, meaning that they report speaking English less than “very well”; this population is vulnerable to poor cancer outcomes, in part as a result of communication problems. Medical interpretating services are mandated by laws and regulations, but access is limited by expense and logistical factors, which may potentially be overcome with technology-enabled solutions. We will compare three types of technology-enabled human-delivered interpreting solutions in a study with limited English proficient breast cancer patients who speak Spanish or Mandarin (1. “UN-style” simultaneous interpretation versus 2. audio consecutive, and 3. video consecutive interpretation) to determine which type has the lowest error rate, has the best patient outcomes, and is the most efficient, and what factors contribute to or impede the implementation of these solutions; we will also explore the potential of artificial intelligence to deliver automated “UN-style” simultaneous medical interpreting, which could be a scalable and inexpensive future solution to providing medical interpreting services to people with cancer.

PI_NAMEs: GANY, FRANCESCA M (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adherence;Administrator;Adoption;Adverse event;Analgesics;Appointment;arm;Artificial Intelligence;Breast;Breast Cancer Patient;cancer care;cancer health disparity;cancer site;Caring;Chinese;Cities;Clinic;Clinical;clinical efficacy;clinical research site;clinically significant;college;Communication;Communication Barriers;Communities;Complex;Consolidated Framework for Implementation Research;cost;Data;Diagnosis;Disease;Effectiveness;Electronic Health Record;Engineering;Enrollment;Equity;evidence base;Face;follow-up;Funding;Future;Goals;health care quality;health disparity;health equity;Healthcare Systems;Human;hybrid type 2 design;Immigrant;improved;improved outcome;Institution;Instruction;Intervention;intervention delivery;Interview;Knowledge;Language;Laws;Limited English Proficiency;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;member;Methods;Modality;Modernization;New York;Newly Diagnosed;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Perception;Persons;Physicians;Policies;policy implication;Population;population health;primary outcome;Process;process evaluation;Provider;Questionnaires;Randomized, Controlled Trials;Regulation;Reporting;Resources;Schools;Screening for cancer;secondary outcome;Serious Adverse Event;service delivery;Services;Site;Spanish;Strategic Planning;Surveys;System;Technology;tool;Transcript;Trust;United States;United States National Institutes of Health

PROJECT_TITLE: RSMI HEALS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Liver Cancer;Liver Disease;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Bile duct cancer, the second most common primary liver cancer, is considered to be an incurable cancer with no identifiable risk factors that can rapidly become lethal, unless it can be detected early enough to be fully resected. Because of the poor prognosis, a technique capable of reliably detecting pre-cancer of the bile duct is urgently needed. We propose to employ the minimally invasive endoscopic light scattering spectroscopy technique for rapid data collection from the entire internal surface of the bile duct and identification of bile duct pre-cancer and early cancer.

PI_NAMEs: PERELMAN, LEV T (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: accurate diagnosis;Adopted;Algorithms;Benign;bile duct;Bile Duct Carcinoma;Bile Duct Epithelium;bile stricture;Biliary;Biochemical;Biometry;Biopsy;Calibration;Cancerous;Catheters;Cell Size;Cellular Morphology;Cellular Structures;Cholangiocarcinoma;Cholelithiasis;Clinical;Clinical Research;Code;Collection;Communication;Computer software;Cytology;Data Collection;decision making algorithm;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic technologies;Diameter;diffuse reflectance spectroscopy;Disease Progression;Doctor of Philosophy;Duct (organ) structure;Early Diagnosis;Endoscopic Retrograde Cholangiopancreatography;Endoscopy;Ensure;Excision;Fiber;Fiber Optics;follow-up;Forcep;Gastroenterologist;Gastroenterology;Gastrointestinal tract structure;Goals;Gold;Histologic;histopathological examination;Histopathology;Image;improved;Inflammatory;Institutional Review Boards;instructor;instrument;instrumentation;International;Israel;Lesion;Light;Light-Scattering Spectroscopy;Liver;Location;Malignant - descriptor;Malignant Neoplasms;mathematical model;Measurement;Measures;Medical center;Medicine;minimally invasive;Morphology;Nature;novel;novel diagnostics;Nuclear;operation;Operative Surgical Procedures;Optics;Organ;Outcome;Paper;Papillary;Pathology;Patients;performance tests;premalignant;Primary Malignant Neoplasm of Liver;Principal Investigator;Procedures;professor;Prognosis;Property;rapid technique;Reproducibility;Resected;Risk Factors;Scanning;Screening for cancer;Side;Specificity;spectrograph;Spectrum Analysis;Speed;Spottings;standard of care;Surface;System;Techniques;Technology;Testing;Time;time use;tissue phantom;Tissue Sample;Translating;Validation

PROJECT_TITLE: Multispectral imaging of bile duct epithelial morphology for early detection of malignancy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Idiopathic pulmonary fibrosis is a chronic, progressive disease that results in lung scarring and breathing difficulty with a median survival of 2-5 years. We hypothesis that aging-associated dysregulation of mechanosignaling drives pulmonary fibrosis. We will exploit a novel in vitro 3D bioengineered microtissue model that mimics healthy and diseased lung tissue to dissect mechanosignaling in aging fibroblasts and a disease-relevant aged mouse model to evaluate inhaled microparticles delivering drugs in alleviating pulmonary fibrosis.

PI_NAMEs: GARCIA, ANDRES J (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Address;Age;age related;aged;Aging;aging mechanism;aging related;Alveolus;Apoptosis;Apoptotic;Area;Automobile Driving;Biocompatible Materials;Biomedical Engineering;Biosensor;Bleomycin;Breathing;cell motility;Chronic;Collagen;cytokine;Cytometry;density;Development;Diagnosis;Disease;Engineering;Exhibits;Exposure to;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;fibrotic lung;Flow Cytometry;Gel;Human;human disease;idiopathic pulmonary fibrosis;Image;Immunoassay;improved;In Vitro;Induction of Apoptosis;Inhalation;inhibitor;innovation;insight;knock-down;Lesion;Lung;Lung Diseases;lung injury;Matrix Metalloproteinases;Measures;mechanotransduction;microdevice;Modeling;Monitor;mouse model;Myofibroblast;nintedanib;novel;old mice;Oral;Outcome;particle;Pathogenesis;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Piezo 1 ion channel;Pirfenidone;Porosity;Profibrotic signal;Progressive Disease;PTK2 gene;Pulmonary Fibrosis;pulmonary function;Research;Resistance;Risk Factors;Role;senescence;senescent cell;Signal Transduction;Small Interfering RNA;Stimulus;Structure;Structure of parenchyma of lung;targeted delivery;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic target;Tissue Engineering;Tissue Model;Tissues;Toxic effect;Weight

PROJECT_TITLE: Mechanosensing in lung fibrosis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative There is increasing recognition that many neurological and psychiatric illnesses are dysfunctions of neural circuit computation. But we lack a theoretical framework for how such neural circuit computations function to support a wide variety of cognitive processes. Through the proposed research, we aim to provide such a theory, thereby providing a better understanding of the details of how brain circuits operate, leading to better assessment, diagnosis, and treatment of a wide range of brain disorders.

PI_NAMEs: HEEGER, DAVID J (contact);MARTINIANI, STEFANO

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Animals;Area;Attention;attentional control;attentional modulation;behavior measurement;Behavioral;Behavioral Model;Brain;Brain Diseases;Brain region;cell type;Cells;Cephalometry;Cognition;Cognitive;cognitive process;Communication;Computer software;Data;Data Analyses;Data Set;Diagnosis;Electrophysiology (science);entorhinal cortex;experimental analysis;Experimental Designs;experimental study;Family;Head;Human;Image;Maintenance;Measurement;Medial;Memory;Mental disorders;Methodology;Modality;Modeling;neural;neural circuit;Neurologic;Neuronal Dysfunction;neurophysiology;Noise;novel;operation;Performance;Population;Prefrontal Cortex;Primates;Publishing;Recurrence;Research;response;Rodent;Sensory;Short-Term Memory;Signal Transduction;Synapses;System;Testing;theories;tool;Update;Visual Cortex;Weight

PROJECT_TITLE: Oscillatory Recurrent Gated Neural Integrator Circuits (ORGaNICs): a unified framework for neural dynamics and human cognition

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative: People with Down Syndrome (DS) have an intellectual disability and are more likely to develop Alzheimer’s Disease (AD) earlier than the general population because of the extra copy of chromosome twenty-one, affecting neuronal activity and connectivity. In this proposal, we are using a three-dimensional patient-derived human cellular model system of regionally-patterned cortical organoids to determine how trisomy 21 affects cellular, functional, and motility-related neuronal properties and the accumulation of pathological proteins. Furthermore, our studies will include organoid xenotransplantations into mouse cortex that provides a neuronal maturation- promoting environment and allows the assessment of how spontaneous and stimulus-induced neuronal function in implanted organoids is impacted in trisomy, which will contribute to our understanding of the mechanisms underlying intellectual deficits and AD pathology in DS.

PI_NAMEs: THUNEMANN, MARTIN ;ZELDICH, ELLA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 3-Dimensional;abeta deposition;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Animal Model;Appearance;Automobile Driving;Autopsy;Axon;Behavior;Behavioral;behavioral study;Biochemical;Biological Models;Brain;brain cell;Calcium;calcium indicator;Cell Line;Cell model;cell motility;Cells;Chimera organism;Chromosome 21;Chromosomes;Cognitive deficits;cognitive disability;density;Development;Dorsal;Down's Syndrome;Early Onset Alzheimer Disease;Electrophysiology (science);Engraftment;Environment;Evaluation;excitatory neuron;Experimental Models;experimental study;Future;General Population;Genes;Genetic;Genomics;Glutamates;graphene;high resolution imaging;Histologic;Human;Human Chromosomes;human migration;Image;Immunodeficient Mouse;Impaired cognition;Implant;improved;In Vitro;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;inhibitory neuron;Intellectual functioning disability;Interneurons;Label;live cell imaging;Measurement;Medial;Methods;Microelectrodes;Microglia;migration;Modeling;Monitor;Morphology;Motility;multi-electrode arrays;multimodality;Mus;myelination;network dysfunction;neurodegenerative phenotype;Neuroglia;neuronal circuitry;Neuronal Differentiation;Neuronal Dysfunction;Neurons;Optics;Organoids;Pathologic;Pathology;Patients;Pattern;Persons;pharmacologic;Phenotype;Physiological;Population;Property;Prosencephalon;Proteins;Reporter;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Stimulus;Synapses;System;therapeutic development;Time;Tissue Stains;transcriptomics;Trisomy;two-photon;Vascularization;Viral;Xenograft procedure

PROJECT_TITLE: Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE The project will examine whether exposure to inhaled microplastics contributes to the development of lung cancer. Microplastic burden in bronchoalveolar lavage fluid will be compared in patients with a new primary lung cancer versus patients with other pulmonary disease. The project will help to fill an important knowledge gap and provide a foundation for future research on the health impacts of this now ubiquitous pollutant worldwide.

PI_NAMEs: EGAN, KATHLEEN M. (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Adenocarcinoma;Adopted;Affect;Age;Atomic Force Microscopy;Biological;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cancer Center;cancer diagnosis;Cancer Etiology;cancer risk;cancer subtypes;carcinogenesis;carcinogenicity;Centrifugation;Cessation of life;Characteristics;Chemicals;chemosensitizing agent;Classification;Clinic;Clinical;clinical diagnosis;clinical practice;Color;Country;Data;demographics;Diagnosis;Diagnostic;Dimensions;Eligibility Determination;Enrollment;Environment;epidemiology study;Evaluation;Exposure to;Fiber;flexibility;Florida;Foundations;Gender;Glass;Health;Human;human tissue;Immune response;Inflammatory Response;Ingestion;Inhalation;insight;Investigation;Knowledge;Laboratories;Lung;lung development;Lung Diseases;Lung infections;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;Medical Records;Methods;Microbial Biofilms;Microscope;microscopic imaging;minimally invasive;Modeling;Morphology;Occupational;Occupations;Operative Surgical Procedures;Optics;Participant;particle;pathogen;Pathology;Pathology Report;Patients;Persons;Physicians;Physics;Pilot Projects;Placenta;Plastics;Poison;pollutant;Pollution;Polyesters;Polymers;Polypropylenes;Population;Primary Neoplasm;Procedures;Process;Race;Raman Spectrum Analysis;Recording of previous events;Recovery;recruit;Recycling;Research;research clinical testing;Research Design;Research Personnel;Risk Factors;Saline;Sampling;Schedule;Series;Shapes;Site;Skin;Smoker;Smoking;Smoking History;Sorting;Sputum;Staging;Structure of parenchyma of lung;Surface;surface coating;Surveys;terephthalate;Textiles;Thoracic Oncology;Universities

PROJECT_TITLE: Epidemiologic study of microplastic pollution in bronchoalveolar lavage fluid and its association with lung cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Hematology;Osteoporosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative In the United States, over 8 million women and 2 million men age 50 and above have osteoporosis and another 51 million women and 35 million men have osteopenia; this translates into a higher risk of fracture within this population, with half of all women and one quarter of men projected to suffer a low bone mass-related fracture. Osteoporotic fractures impart deleterious consequences, including increased hospitalization and mortality; an estimated 25% of individuals will die within one year of a hip fracture. This project explores the role of novel myeloid subsets in limiting age-associated cortical bone loss.

PI_NAMEs: BRADLEY, ELIZABETH W (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Age;age related;aged;Aging;Anabolic Agents;animal old age;Arthritis;Biological Assay;Blood;bone;bone aging;Bone Diseases;bone loss;Bone Marrow;bone marrow mesenchymal stem cell;Bone Marrow Transplantation;bone mass;Bone remodeling;Bone Resorption;Cell Lineage;Cells;Collagen;cortical bone;Coupling;cytokine;Data;Development;Disease;Economic Burden;Erythro;Exhibits;experimental study;Femur;Flow Cytometry;Fracture;fracture risk;Growth Factor;Hematopoietic;Hematopoietic stem cells;high risk;Hip Fractures;Hip region structure;Hospitalization;Human;improved;In Vitro;Individual;innovation;ITGAM gene;juvenile animal;Knowledge;Link;Maintenance;Mediating;men;microCT;Modeling;Molecular;Molecular Target;mortality;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Natural regeneration;novel;novel therapeutics;old mice;osteoclast progenitor;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;Outcome Study;Periodontitis;Physiology;Population;Process;Production;reconstitution;Risk;Role;Series;Skeletal bone;social;spine bone structure;stem cell expansion;substantia spongiosa;Surface;targeted treatment;Testing;Therapeutic;Thick;Transfusion;Translating;Transplantation;tumor;United States;Vertebral column;Woman;Work

PROJECT_TITLE: Cellular Mechanisms of Age-Associated Cortical Bone Remodeling

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Precision Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the US, yet therapeutic options are limited. The advent of electronic health data has brought an unprecedented opportunity to accelerate drug discovery and identify new therapeutic options for COPD among existing drugs (drug repurposing). Building on state-of-the-art methods for causal inference and existing claims data sources, supplemented with EHR data and deeply phenotyped data from COPDGene, we will develop, test, and implement an analytics and data infrastructure to efficiently evaluate non-COPD medications for COPD.

PI_NAMEs: BYKOV, KATSIARYNA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acceleration;Address;Age;Agonist;Algorithms;beneficiary;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Collection;comorbidity;comparative effectiveness;computerized tools;Data;data infrastructure;Data Reporting;Data Sources;Dermatology;Diabetes Mellitus;Disease;Disease Management;Disease Outcome;disease phenotype;disorder subtype;drug discovery;drug repurposing;electronic health data;Electronic Health Record;Ethnic Origin;Evaluation;Foundations;Future;GLP-I receptor;Goals;health data;Healthcare;Heterogeneity;immune modulating agents;improved;Individual;Infrastructure;insurance claims;Investigation;Knowledge;Link;Literature;Measurement;Medicare;Metformin;Methodology;Methods;Monitor;Morbidity - disease rate;mortality;multiple data sources;new therapeutic target;novel therapeutics;Observational Study;Outcome;Patient Care;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;phenotypic data;population based;Positioning Attribute;Prevention;Race;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research Personnel;Rheumatology;Scientific Advances and Accomplishments;Severity of illness;sex;Smoker;Subgroup;Testing;Therapeutic;Time;treatment effect;Update;Work

PROJECT_TITLE: Evaluating the Impact of Non-COPD Medications on COPD Management

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: GREENSBORO

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

ORG_STATE: NC

PHR: Project Narrative Latine children in the U.S. experience disproportionate rates of obesity and type 2 diabetes compared to children of other racial/ethnic groups. Hence, interventions that ensure nutrition security and reduce obesity risk and insulin insensitivity among Latine children are vital, ensuring health equity.

PI_NAMEs: DEJESUS, JASMINE ;DHAROD, JIGNA MORARJI (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Age Months;aged;Birth;boys;Breast Feeding;breast pump;Calories;Cessation of life;Child;Clinic;Clinical Trials;community organizations;comparison control;Complementary Feeding;Control Groups;culturally appropriate intervention;Data;Diabetes Mellitus;Disease;Disparity;early onset;effective intervention;effectiveness measure;effectiveness testing;Eligibility Determination;Energy-Generating Resources;Enrollment;Ensure;Ethnic Population;excessive weight gain;Exclusive Breastfeeding;experience;feeding;gender difference;Generations;girls;Goals;group intervention;Health Care Costs;health equity;Healthcare;high risk;Home visitation;Household;Human Milk;improved;Incentives;Incidence;Individual;infancy;Infant;infant adiposity;Infant formula;Insulin;Insulin Resistance;Intake;Intervention;Knowledge;Latin American;Latinx;Length;Life;Linguistics;Low income;Mediating;Milk;Mission;Morbidity - disease rate;Mothers;Multivariate Analysis;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;Participant;peer;Phase;pilot trial;Population;Postpartum Period;premature;Prevalence;prevent;Prevention strategy;process evaluation;productivity loss;Professional counselor;programs;Public Health;Qualitative Research;racial population;Randomized, Controlled Trials;rapid weight gain;Recommendation;recruit;response;retention rate;Risk;Security;Self Efficacy;skills;social cognitive theory;Source;Special Supplemental Nutrition Program for Women, Infants, and Children;trend;type 2 diabetes in children;Weight;Weight Gain;Woman;Work;Youth

PROJECT_TITLE: Breastfeeding intervention to prevent obesity among Latine children

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Hematopoietic stem cells (HSCs) are a population of tissue-specific stem cells that live in the bone marrow and both continuously regenerate and replenish blood and immune cells during life. HSCs are the therapeutic component of bone marrow transplants. HSCs are born in the developing embryo and we seek to understand the native conditions that produce HSCs in order to help support attempts to generate them in vitro as a resource for transplant therapies, pharmacological investigation, and disease modeling.

PI_NAMEs: CLEMENTS, WILSON KENDRICK (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;Animals;Aorta;Architecture;biophysical properties;Biophysics;Blood;Bone Marrow;Bone Marrow Transplantation;Cell Line;Cell model;Cell Ontogeny;Cells;Clinical;Collagen;comparative;Complex;crosslink;Development;differentiation protocol;Dioxygenases;directed differentiation;Disease;disease model;Embryo;Enzymes;Extracellular Matrix;Fiber;Gene Delivery;Gene Expression Profiling;gene therapy;Genes;Genetic;genetic approach;Gonadal structure;Hematological Disease;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell emergence;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hemogenic endothelium;Immune;improved;In Vitro;in vivo;Individual;Integrins;interest;Investigation;Investments;knock-down;leukemia;Life;loss of function;Lysine;Mammals;Mesonephric structure;migration;Modality;Molecular;Mus;Natural regeneration;Non-Malignant;novel;Pathway Analysis;Pathway interactions;pharmacologic;Population;Post-Translational Protein Processing;Process;Procollagen;Proliferating;Proteins;Proteoglycan;receptor;Recommendation;Resources;Role;self renewing cell;Sickle Cell Anemia;Signal Transduction;Smooth Muscle Myocytes;Specific qualifier value;stem cells;Structure;Testing;Text;Therapeutic;Tissues;Transmission Electron Microscopy;transplantation therapy;Vascular Smooth Muscle;Vertebrates;Zebrafish

PROJECT_TITLE: Extracellular matrix in vertebrate hematopoietic stem cell specification

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE This project will determine the contribution of the gut microbiome to the effects of gender affirming hormone therapy (GAHT) in mice. Our study will provide information on whether GAHT exerts effects on skeletal maturation, and the mechanisms whereby the gut microbiome mediates the skeletal effects of GAHT. The project is important because the skeletal effects of GAHT in humans is a critical medical concern in transgender medicine.

PI_NAMEs: JONES, RHEINALLT MELFYN;PACIFICI, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 16 year old;Address;Affect;Agonist;Antibiotic Therapy;Bacteria;bone;bone health;Bone Marrow;bone mass;Bone Resorption;Cell Lineage;Cells;Characteristics;Clinical;Complex;Data;Estradiol;Estrogen Therapy;Estrogens;fecal microbiome;Female;Female Adolescents;Frequencies;gender affirmation;gender affirming hormone therapy;gender dysphoria;Gender Identity;Gnotobiotic;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;gut microbiome;Gut Mucosa;Health;hormone therapy;Human;human female;Immune;immune activation;immunoregulation;Impairment;indexing;intervention effect;Intestinal permeability;Intestines;Knowledge;Leuprolide;male;Male Adolescents;Mediating;Medical;Medicine;Menopause;Metagenomics;Methodology;microbiome;microbiome alteration;microbiome composition;migration;Modification;mouse model;Mus;Osteogenesis;Persons;postnatal;Production;Protocols documentation;Puberty;puberty blocker;Publishing;Regulation;Regulatory T-Lymphocyte;Reporting;sexual dimorphism;skeletal;Skeletal bone;skeletal maturation;Skeleton;social;Steroid therapy;Structure;Techniques;Testing;Testosterone;Time;transgender;transgender men;transgender women;treatment effect

PROJECT_TITLE: Microbiome mediated effects of gender affirming hormone therapy in mice

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lymphatic Research;Lymphedema;Pediatric;Social Determinants of Health

ORG_DEPT: PATHOLOGY

PHR: Skin and soft tissue bacterial infections, along with the emergence of antibiotic resistant bacterial strains, pose significant challenges to public health. Our objective is to uncover the molecular mechanisms underlying compromised lymphatic vessel function during and after skin and soft tissue infections, while also understanding the relationship between impaired lymphatic vessel function and compromised immunity. Identification of these molecular mechanisms will inform novel therapeutic targets to enhance lymphatic vessel function and anti-bacterial immunity, effectively breaking the cycle of infection and lymphatic vessel dysfunction.

PI_NAMEs: JONES, DENNIS  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: adaptive immunity;Address;Affect;American;Anti-Bacterial Agents;Antimicrobial Resistance;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Biological Sciences;Biology;Biomedical Research;Blood Vessels;Boston;Calcium;Calcium Signaling;career;Career Choice;Cell Death;Cell Physiology;Cellulitis;Chronic Disease;Clinical;college;College Preparation;Communities;Cytoprotection;Data;Dedications;design;Development;Education;empowerment;Exhibits;experience;experimental study;Exposure to;Faculty;Fatty acid glycerol esters;FDA approved;Fluid Balance;Fostering;Functional disorder;Future;Generations;Genetic;Genetic Transcription;Goals;Growth;high school;High School Student;imaging study;immune function;Immunity;Immunofluorescence Microscopy;Impairment;improved;in vivo;Individual;Infection;Infectious Skin Diseases;Infrastructure;inhibitor;Injury;interest;Intervention;intravital imaging;Laboratories;laboratory experience;Lead;lectures;Low Income Population;lower income families;lymph flow;Lymphatic;Lymphatic Diseases;lymphatic dysfunction;Lymphatic function;lymphatic vessel;Lymphedema;Mathematics;Measures;medical schools;Medicine;member;Mentors;methicillin resistant Staphylococcus aureus;Microbiology;Modeling;Molecular;Morbidity - disease rate;Morphology;Mus;Muscle Cells;new therapeutic target;Participant;Pathologic;Pathway interactions;peer;pharmacologic;Phenotype;Positioning Attribute;preservation;Problem-Based Learning;Production;programs;Proliferating;Public Health;Publishing;Race;Recurrence;Regenerative response;Regulation;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk;Schools;Science;Scientific Advances and Accomplishments;scientific literacy;Secure;single-cell RNA sequencing;Skin Tissue;soft tissue;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;STEM career;STEM field;Structure;Students;subcutaneous;success;summer program;summer research;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;Toxin;Training;Treatment Efficacy;Underrepresented Minority;Underrepresented Students;Universities;university student;Virulence;Virulence Factors;Work

PROJECT_TITLE: Enhancing immunity by protecting lymphatic muscle cells from MRSA-Induced dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: PROJECT NARRATIVE This project addresses unmet needs in targeted protein degradation therapeutics and develops a series of programmable and conditional Proteolysis Targeting Chimeras (PROTACs) enabled by nucleic acid nanotechnology.

PI_NAMEs: YAN, HAO  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Advanced Development;Affect;Affinity;Antibodies;Antisense Oligonucleotides;aptamer;Binding;Biological;Biosensor;Breast Cancer Cell;CDK4 gene;cell type;Cell-Free System;Cells;Characteristics;Chemicals;clinical application;Clinical Trials;cost;cost effective;Coupled;Cytoplasm;delivery vehicle;design;Development;Disease;DNA;Drug Delivery Systems;Engineering;Ensure;experience;experimental study;Face;Goals;Growth;immunogenicity;improved;In Vitro;innovation;interest;Libraries;Ligands;MCL1 gene;Mediating;Methodology;Modality;Molecular;multicatalytic endopeptidase complex;nanodevice;nanomolar;Nanostructures;Nanotechnology;Nature;next generation;novel;Nucleic Acids;oligonucleotide therapeutics;Oligonucleotides;Peptides;Permeability;Pharmaceutical Preparations;Pharmacology;Production;Protac;protein activation;Protein Binding Domain;protein degradation;Proteins;Proteome;RNA;scaffold;screening;Series;side effect;small hairpin RNA;small molecule;small molecule inhibitor;Specificity;Structure;success;System;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic gene;Time;Tissues;Translations;tumor;Ubiquitin;ubiquitin-protein ligase;uptake;Vaccines;Validation;Variant;Vertebral column

PROJECT_TITLE: Programmable and Conditional Proteolysis Targeting Chimeras Enabled by DNA Nanotechnology

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health

ORG_CITY: STONY BROOK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative We aim to develop a high-resolution model for temperature on a 30-meter scale for all roads in the contiguous United States from 2000 to 2020. We will in turn use this data to conduct epidemiological analyses looking at the relationship between temperature and morbidity and mortality using robust statistical methods. In the course of these analyses, we will identify populations who are most vulnerable to the health effects of temperature and climate change.

PI_NAMEs: DANESH YAZDI, MAHDIEH  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Affect;Age;Air Pollution;Area;Calibration;causal model;Censuses;Cessation of life;Characteristics;Cities;climate change;climate impact;climate variability;climate-related exposures;Communities;computer infrastructure;Cross-Over Studies;Data;Data Set;demographics;deprivation;design;Development;Emergency department visit;Ensure;environmental justice;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Origin;experience;Exposure to;follow-up;Health;health assessment;heat island;High temperature of physical object;Individual;Inpatients;Intervention;Joints;land use;Life;life span;Link;Long-Term Effects;Machine Learning;machine learning algorithm;Measurement;Measures;member;meter;Methodology;Methods;Modeling;Modification;Morbidity - disease rate;mortality;mortality risk;Outcome;Policy Maker;Population;population based;Population Group;Poverty;predictive modeling;Predisposition;psychosocial stressors;Public Health;Race;remote sensing;Research;Research Design;Research Personnel;residence;Resolution;response;Rest;Risk;Seasons;social deprivation;social vulnerability;Socioeconomic Status;socioeconomics;Source;spatiotemporal;Spottings;Statistical Methods;Subgroup;Sum;Temperature;Testing;Time;Training;Translating;Trees;United States;US State;Variant;weather stations

PROJECT_TITLE: Population-Based Assessment of the Health Effects of Climate Exposure Using Hyperlocal Predictive Models

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Precision Medicine;Prevention;Rehabilitation;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Through a national, multicenter, randomized controlled trial, we will evaluate the effect of a shared decision- making (SDM) toolkit versus Usual Care on the utilization of surveillance mammography in breast cancer survivors ≥80 years of age. We will also examine decisional quality, knowledge, and clinical outcomes in addition to multi-level facilitators and barriers to toolkit implementation and discontinuation of mammography. Successful toolkit implementation that leads to individualized discussions and appropriate use of mammography will help to minimize the harms of testing for the large and growing population of older breast cancer survivors through a patient-centered approach.

PI_NAMEs: FREEDMAN, RACHEL ANN (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acceleration;Age;Age Years;aged;Annual Reports;Anxiety;Attitude;Biopsy;Breast Cancer survivor;Breast Cancer survivorship;breast imaging;Cancer Center;cancer diagnosis;Caring;Clinical;comorbidity;Companions;Complex;Conflict (Psychology);Consensus;Consolidated Framework for Implementation Research;Data;Decision Making;design;Development;Diagnosis;Diagnostic;Early Diagnosis;Effectiveness;effectiveness evaluation;efficacy evaluation;Enrollment;Evaluation;evidence base;experience;follow-up;Goals;Guidelines;Harm Reduction;Image;implementation barriers;improved;improved outcome;Individual;Indolent;innovation;Internist;Intervention;Interview;Knowledge;Leadership;Life Expectancy;Malignant Breast Neoplasm;Mammography;Measures;National Cancer Institute;novel;older adult;Older Population;older women;Oncologist;Oncology;Outcome;overtreatment;participant enrollment;patient oriented;Patients;person centered;personalized approach;Population;pragmatic trial;preference;primary care clinician;primary endpoint;Process;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Science;Scientist;Self Efficacy;shared decision making;Site;Structure;Surveys;Survivors;survivorship;Symptoms;Testing;Time;Translating;treatment as usual;uptake;Woman

PROJECT_TITLE: Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE Cellular heterogeneity and lineage plasticity pose tremendous challenges for developing cell-targeted therapies and biomarkers of clinically significant prostate cancer. This proposal will use new mouse and organoid models to investigate the mechanisms underlying luminal plasticity and cellular diversification focusing on a novel luminal transcriptional state with a unique “basal-like” Wnt/p63 signaling (luminal intermediate, LumI) that contributes to clonal expansions of luminal cells in aging and prostate cancer models. Our studies will yield essential insights into the functional and molecular heterogeneity sustaining adult prostate homeostasis and the age-related dysregulated mechanisms of lineage plasticity that allow expansions of malignant clones in progressive prostate cancer.

PI_NAMEs: TALOS, FLAMINIA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Ablation;Address;Adult;Age;age related;aged;Aging;anti-cancer research;Benign;Biological Assay;cancer cell;cell type;Cells;clinically relevant;clinically significant;Clonal Expansion;cofactor;Communities;Coupled;Data;Dependence;Detection;Development;early detection biomarkers;Ensure;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;experimental study;gain of function;gene regulatory network;Genes;Genetic;Genetic Complementation Test;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Healthcare Systems;Heterogeneity;Homeostasis;Hormone imbalance;Human;Human Pathology;Hybrid Cells;Hybrids;In Vitro;in vivo;innovation;insight;Lesion;Ligands;loss of function;Maintenance;male;male health;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Molecular;mouse model;Mus;neoplastic cell;new therapeutic target;novel;novel marker;old mice;Organoids;Pathology;Phenotype;Population;Predisposition;prevent;programs;Proliferating;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;prostate cancer risk;prostate carcinogenesis;prostate enlargement;Prostatic Diseases;Proteins;Role;Sampling;Signal Transduction;Source;stem cells;Subcellular Anatomy;synthetic biology;targeted biomarker;targeted cancer therapy;targeted treatment;Testing;therapy design;tissue regeneration;Tissues;tool;transcriptome sequencing;transcriptomics;translational impact;translational potential;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;tumor heterogeneity;tumor progression;tumorigenesis;Validation;WNT Signaling Pathway

PROJECT_TITLE: Investigating luminal plasticity in prostate tumorigenesis

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Precision Medicine

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Many older adults use sedating medications for pain, anxiety, and mood, which can have harmful effects on their health. Deprescribing, a process that safely reduces or stops these medications, holds great potential to improve the well-being of older adults, especially if personalized and data- driven support is available. This proposal aims to enhance deprescribing efforts by 1) leveraging medical records and artificial intelligence to personalize deprescribing recommendations, and 2) examining factors that optimize doctors' and patients' understanding and trust in artificial intelligence-driven clinical guidance on deprescribing.

PI_NAMEs: PAVON, JULIESSA M (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: adverse outcome;Affect;American;Analgesics;Anti-Cholinergics;anti-depressive agents;Antipsychotic Agents;Anxiety;Artificial Intelligence;Benzodiazepines;Caregivers;Central Nervous System;Cessation of life;Characteristics;Clinical;clinical practice;Clinical Trials;Clinical Trials Design;community partners;Complex;Comprehension;Data;data modeling;Decision Making;Decision Trees;design;Effectiveness;efficacy testing;Elderly;Electronic Health Record;empowerment;Ensure;experience;Exposure to;falls;Feedback;Foundations;Future;Goals;Guidelines;hands-on learning;Harm Reduction;Health;Hospitalization;hypnotic;Impaired cognition;improved;Individual;individual patient;individualized medicine;Infrastructure;Injury;innovation;Intervention;Lead;Link;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Medical Records;Medicare;Medicare claim;Medication Systems;Methodological Studies;Methods;Modeling;Moods;Muscle relaxants;Neurologist;older adult;Opioid;Outcome;patient subsets;Patient-Centered Care;Patient-Focused Outcomes;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phase;physical impairment;Polypharmacy;predictive modeling;preference;primary care provider;Probability;Process;Property;prototype;Psychiatrist;Quality of life;Recommendation;Research;Risk;Safety;Sedation procedure;Series;shared decision making;Site;Specialist;supervised learning;Symptoms;Syndrome;Techniques;Thinking;Training;trend;Trust;trustworthiness;unsupervised clustering;unsupervised learning;user-friendly;Work

PROJECT_TITLE: Deprescribing Decision-Making using Machine Learning Individualized Treatment Rules to Improve CNS Polypharmacy

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative Given the desire to move from fossil fuels to renewable energy sources, the market for wood pellets is booming, and wood pellet production plants are rapidly sprouting up across the United States, most notably in predominantly black and poor communities in the deep south. Taking advantage of the staggered opening of wood pellet production plants in Mississippi--a state also grappling with significant pediatric health and quality of life issues, this project will measure and model the propagation of both air and noise pollution from wood pellet production into the surrounding community and will examine how and to what extent these wood pellet production exposures impact the health and well-being of children living nearby. Understanding how multiple physical and chemical environmental exposures impact children’s respiratory and stress health will reveal key insights that can help us better assess economic benefits against environmental health costs of wood pellet production as an alternative energy source and investing in local human capital will create a cohort of diverse, local researchers and concerned residents who will become first-authors in their future stories.

PI_NAMEs: WALKER, ERICA  (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Adolescent;Age;Air;Air Pollution;ambient air pollution;Area;Aromatic Polycyclic Hydrocarbons;Asthma;Awareness;Behavior Disorders;behavior influence;Biomass;Black race;Books;Child;Child Health;Child Welfare;Childhood;Childhood Asthma;Chronic;climate change;Cognition Disorders;cohort;Communities;community college;community engagement;Community Health;Data;Deep South;Development;Disparity;economic disparity;economic evaluation;Economics;Energy-Generating Resources;Enrollment;environmental chemical exposure;Environmental Health;epidemiology study;Exhibits;Exposure to;Fossil Fuels;Frequencies;Future;Goals;graduate student;Hair;Health;Health Care Costs;health difference;health disparity;High School Student;Home;Household;human capital;Hydrocortisone;improved;indexing;indoor air;Indoor Air Quality;indoor concentrations;Industrial Waste;Industrialization;Industry;Infiltration;insight;Intervention;Investments;Joints;Life Cycle Stages;Link;literacy;Loudness;Low Birth Weight Infant;manufacture;manufacturing facility;Marketing;Measurement;Measures;Mississippi;Modeling;Neighborhoods;noise exposure;noise pollution;older adult;Outcome;Particulate Matter;Personal Satisfaction;Pilot Projects;Plants;Policies;pollutant;Pollution;poor communities;Production;Property;psychological distress;Psychological Stress;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;renewable energy;Research;Research Personnel;Research Training;Resolution;Resources;respiratory;Respiratory Disease;respiratory health;Risk;Rural;Series;social;sound;Stress;stressor;structural determinants;Symptoms;tool;undergraduate student;United States;university student;volatile organic compound;Wood material

PROJECT_TITLE: Wood Pellet Emissions and Children's Environmental Health in Mississippi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative: This proposal in response to PAR-22-085: Microbial-based Cancer Imaging and Therapy - Bugs as Drugs, is relevant to public health since it focuses on metastatic pancreatic ductal adenocarcinoma (PDAC), a cancer considered particularly difficult to target and generally unresponsive to current therapies. We propose to investigate the systemic administration of genetically-engineered Bifidobacterium delivering a novel human IL- 2 (SumIL2) to the TME in combination with radiotherapy and/or immunotherapy. Our approach takes advantage of the natural features and genetic engineering of Bifidobacterium to reinvigorate the immune suppressive TME via systemic injection, and thus could have broad applicability in other hard-to-treat cancers.

PI_NAMEs: MIMEE, MARK ;WEICHSELBAUM, RALPH R (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Address;Affect;Anaerobic Bacteria;antagonist;anti-cancer;Anti-CD47;antitumor effect;Area;Bacteria;bacterial vector;Bifidobacterium;Biomedical Engineering;Cancer Etiology;cancer imaging;cancer therapy;CD47 gene;cell regeneration;Cells;checkpoint inhibition;checkpoint therapy;chemotherapy;clinically relevant;Combined Modality Therapy;cytokine;Data;delivery vehicle;Dendritic Cells;design;Disease;Dose;Drug Delivery Systems;Drug resistance;Drug Targeting;Effectiveness;Engineering;Escherichia coli;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;Goals;Homing;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Stimulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;Injections;innovation;Interferon Type I;Interleukin-2;Ionizing radiation;KPC model;Malignant Neoplasms;Mass Spectrum Analysis;Metastatic Neoplasm to the Liver;Methods;microbial;microbial based therapy;Micrometastasis;Modeling;Molecular;mortality;mouse model;Mus;nanobodies;Natural Killer Cells;novel;Oral;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Pharmaceutical Preparations;pre-clinical;Production;programs;Proliferating;Protein Secretion;Public Health;Radiation therapy;Regulation;Relapse;Reporting;Research;Resistance;response;side effect;stem;STING agonists;synergism;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;tool;Toxic effect;tumor;Tumor Escape;tumor growth;tumor hypoxia;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;United States

PROJECT_TITLE: Genetically-engineered Bacteria Overcome Therapy Resistance

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Infectious Diseases;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Human papilloma virus-induced cancers of the throat are becoming much more common, and difficulty distinguishing easily curable cases from more serious ones prevents tailoring treatment to be adequately effective but not unnecessarily toxic for each individual patient. This project explores how differences in the levels of a particular viral protein within each cancer influences how quickly it spreads and how well it responds to treatment. This effort will help minimize treatment toxicity for easily curable patients while helping to identify more effective therapies for the most serious cases.

PI_NAMEs: BASU, DEVRAJ  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Antioxidants;Biogenesis;Biological Markers;cancer cell;cancer type;Chromatin;Chromatin Remodeling Factor;Cisplatin;Clinical;Dependence;disability;Disease;Disease Progression;Distant Metastasis;effective therapy;Enzymes;Future;Genes;Growth;high risk;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hypoxia;Individual;individual patient;individualized medicine;ineffective therapies;Intervention;Invaded;Knowledge;Lifelong disability;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Metabolism;Mitochondria;Modeling;Molecular;Molecular Target;Neoplasm Metastasis;neoplastic cell;Nutrient Depletion;Oncogenic;Oncoproteins;Oropharyngeal Squamous Cell Carcinoma;overtreatment;Oxidative Stress;Oxidative Stress Induction;Papillomavirus Transforming Protein E6;Pathway interactions;Patients;personalized medicine;Phenocopy;preservation;prevent;prospective;Proteins;Radiation;Radiation Dose Unit;radiation response;Recurrence;Repression;Resistance;Risk;risk stratification;Role;standard care;Survivors;System;Testing;Therapeutic;therapy design;therapy resistant;Throat Cancer;tool;Toxic effect;TP53 gene;Treatment Failure;treatment response;Treatment-related toxicity;tumor;tumor progression;Viral Proteins

PROJECT_TITLE: Exploiting differences in HPV oncoprotein function among oropharyngeal cancers to personalize therapy

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Dietary Supplements

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Choline is an essential metabolite for wide range of cellular processes, but how mammalian tissues import serum choline has been poorly understood. In this proposal, we will test the hypothesis that FLVCR1 and its close paralog FLVCR2 are required for choline transport and homeostasis in mammals. Our work will provide unprecedented physiological and structural insight into the role of choline transport in mammalian physiology and disease.

PI_NAMEs: BIRSOY, KIVANC  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adult;Affinity;Binding;Binding Sites;Biochemical;Biochemical Pathway;Biological Assay;Carbon;Carrier Proteins;Cell membrane;Cell Physiology;Cell Proliferation;Cells;Cellular Assay;Cellular Membrane;Cellular Metabolic Process;Cholesterol;Choline;choline transporter;cholinergic;cohort;Compensation;CRISPR/Cas technology;Data;Defect;Dietary Component;Disease;Embryo;Embryonic Development;Environment;Ethanolamines;experimental study;extracellular;Feline Leukemia Virus;Genes;Genetic Determinism;Genetic Screening;genome wide association study;Head;Health;Homeostasis;Human;Hydrophobicity;Impairment;improved;Individual;insight;Lecithin;Ligand Binding;Ligands;Link;Lipids;Liposomes;Liver;liver metabolism;Mammalian Cell;Mammals;Mediating;Membrane;Membrane Proteins;Membrane Transport Proteins;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;Mutation;neurotransmission;non-alcoholic fatty liver disease;Nutrient;Organ;Outcome;paralogous gene;Pathway interactions;Phospholipids;Phosphorylcholine;Physiological;Physiology;Plasma;receptor;Role;Serum;Signal Transduction;small molecule;Structure;Subgroup;Testing;Tissues;uptake;Visualization;Vitamins;Work

PROJECT_TITLE: The physiological and molecular function of choline transport in health and metabolic disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: KANSAS CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Obesity poses a major health risk, and children living in rural areas have higher rates of obesity than their urban counterparts. Based upon our extensive prior work, we propose a multilevel factorial design randomized controlled trial with interventions at the clinic and individual patient level to treat pediatric obesity among underserved rural children and families. These interventions could fundamentally change the treatment of the 41% of rural children who are overweight or obese and lead to a decrease in cancer.

PI_NAMEs: DARDEN, PAUL M;DAVIS, ANN M (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Academy;Address;Adult;American;Behavior Therapy;Behavioral;Body mass index;Cardiovascular Diseases;Caregivers;Caring;Child;Child Health;Childhood;chronic care model;Clinic;Clinical Practice Guideline;Clinical Trials Network;Communication;compare effectiveness;comparison control;Consent;Counseling;design;Diabetes Mellitus;Diet;Documentation;Dose;effectiveness evaluation;Family;family support;Feasibility Studies;feasibility trial;Feedback;group intervention;Guidelines;Health;Hour;improved;Individual;individual patient;Intervention;Malignant Neoplasms;Manuals;Measurement;Medical;meetings;member;Methods;mHealth;modifiable risk;Morbidity - disease rate;mortality;multidisciplinary;Newsletter;Obesity;obesity in children;obesity prevention;obesity treatment;Outcome;Overweight;Participant;participant enrollment;Patient Recruitments;Patients;Pediatrics;Performance;Population;post intervention;Prevention;Primary Care;primary care clinic;Procedures;Process;programs;Provider;provider intervention;Publishing;Randomized;randomized controlled design;randomized, clinical trials;Randomized, Controlled Trials;recruit;Recruitment Activity;remote technology;remote therapy;Research Personnel;Risk;Risk Factors;Rural;rural area;rural families;rural health clinic;Rural Population;rural underserved;skills training;social health determinants;therapy design;Time;tool;Training;treatment program;United States Preventative Services Task Force;Weight maintenance regimen;Work

PROJECT_TITLE: Implementation of the New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Glaucoma affects millions, leading to significant vision loss; current limitations in predicting disease risk and progression result in potential preventable blindness and inefficient resource allocation. This project aims to refine glaucoma risk prediction and prognostication by combining advanced genomics and computational tools. Successful implementation could transform early disease detection, optimize treatment, preserve vision, and conserve medical resources, yielding a profound positive impact on public health.

PI_NAMEs: ZEBARDAST, NAZLEE  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Affect;biobank;Biological;Blindness;Boston;Caring;cell type;Clinical;clinical center;cohort;Complex;Computational Technique;computerized tools;Data;Data Set;Detection;Development;Disease;disease phenotype;Disease Progression;disorder risk;Early Diagnosis;Effectiveness;Electronic Health Record;Failure;Fortification;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;genetic variant;genome wide association study;genomic data;genomic tools;Genomics;Glaucoma;Goals;high risk;Image;improved;Individual;innovation;insight;interdisciplinary approach;International Classification of Disease Codes;International Classification of Diseases;Knowledge;Link;Machine Learning;machine learning method;machine learning model;Medical;Meta-Analysis;Methodology;Methods;Modeling;Monitor;multi-ethnic;multiple datasets;Natural Language Processing;novel;Open-Angle Glaucoma;Ophthalmology;Optical Coherence Tomography;Participant;Pathway interactions;Patients;Performance;personalized approach;personalized management;personalized risk prediction;Phenotype;polygenic risk score;precision medicine;preservation;Primary Open Angle Glaucoma;prognostication;programs;Public Health;Publishing;Records;Resolution;Resource Allocation;Resources;Risk;Risk Assessment;risk prediction;risk stratification;Severity of illness;Specificity;statistics;Techniques;tool;Training;treatment optimization;treatment response;unsupervised learning;Variant;Veterans;Vision;Visual impairment

PROJECT_TITLE: Enhancing Glaucoma Risk Prediction through Advanced Genomics and Machine Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-N (90)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Orphan Drug;Palliative Care;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a more thorough understanding of drivers of racial/ethnic disparities in utilization of medications to manage pancreatic cancer- related symptoms and improve health-related Quality of Life. Once a greater understanding has been developed, there is the potential for significant advances in symptom management for minority patients with pancreatic cancer. Thus, the proposed research is relevant to NIMHD’s mission to improve minority health and reduce health disparities.

PI_NAMEs: ALLEN, JOHN M (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accounting;African;African American;Agitation;Analgesics;Anti-Anxiety Agents;anti-depressive agents;Antipsychotic Agents;Anxiety;Behavioral Model;behavioral phenotyping;black patient;built environment;Cancer Etiology;cancer type;Caribbean region;Cessation of life;Characteristics;Clinical;Data;Data Sources;Databases;Development;Diagnosis;Dimensions;Disparity;Drug Prescriptions;Education;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Food Access;Foundations;Future;Goals;Health;health care disparity;health related quality of life;health service use;improve minority health;improved;inclusion criteria;Income;Individual;individual patient;informant;innovation;insight;Intervention;Interview;Knowledge;Learning;lens;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicare;Mental Depression;mental function;Methodology;Methods;minority patient;Mission;Modeling;Morbidity - disease rate;mortality;multiple data sources;National Institute on Minority Health and Health Disparities;Neurologic;Neurologic Symptoms;novel;Opioid;Outcome;Pain;pancreatic cancer patients;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physical Function;Population;Provider;provider factors;psychiatric symptom;Psychosocial Factor;Public Health;Race;racial disparity;racial health disparity;racial minority;racial population;recruit;Reduce health disparities;reduce symptoms;Research;Risk Factors;Sampling;social;Social Behavior;social capital;Social Environment;Social Functioning;social health determinants;social influence;sociocultural determinant;sociodemographic factors;stakeholder perspectives;Structure;Supportive care;Surveys;Survival Rate;Symptom Burden;symptom management;symptomatic improvement;Symptoms;Techniques;Testing;United States;walkability

PROJECT_TITLE: Examining the determinants and consequences of supportive care medication use disparities in patients with pancreatic cancer: A sequential mixed-methods approach


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative This proposal concerns the development of natural language processing methods and tools that establish essential guardrails to the safe use of large language models (LLMs) when used to simplify medical texts. The premise is that LLMs oﬀer the tantalizing opportunity to enable lay access to newly published evidence, but current models risk introducing inaccurate information into automatically simpliﬁed texts; this proposal concerns designing techniques that mitigate such risk. These kinds of “safe generation” techniques have the potential to empower users with the ability to critically read LLM outputs; our immediate, important aim is to enable access to trustworthy plain language summaries of medical evidence, but the developed methods will have application in similar contexts where “safe” generation is critical.

PI_NAMEs: LI, JUNYI JESSY (contact);WALLACE, BYRON CASEY;XU, WEI

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TITLE: Building Safety Guards into LLMs for Trustworthy Automatic Simplification of Medical Documents

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The predominant focus of studying the underlying causes of congenital heart disease (CHD) has been on interrogating transcriptional regulators of early cardiac development, however recent progress proposes that post-transcriptional mechanisms, and specifically mechanisms that regulate RNA, play major roles during normal heart development. Here we have identified DDX3X as a new RNA-binding protein required in multiple cell types of the cardiovascular lineages during development. The proposed work will study the cell type-specific mechanisms by which DDX3X regulates normal heart development and interrogate how mutations in DDX3X found in humans with CHD affect its function.

PI_NAMEs: DUBOIS, NICOLE  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Affect;Alternative Splicing;Animals;Area;autism spectrum disorder;Biological;Biological Process;brain malformation;candidate identification;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cell Cycle;Cell Cycle Regulation;Cell Nucleus;cell type;Cells;Code;Complex;congenital heart abnormality;Cytoplasm;Data;Defect;Development;Disease;disease-causing mutation;dosage;Embryo;Female;Frequencies;Functional disorder;Genes;Genetic Transcription;Genotype;Goals;Heart;heart defect;Heart Diseases;Human;Human Genome;Individual;insight;Intellectual functioning disability;Knowledge;Lead;link protein;loss of function;male;mammalian genome;Modeling;Modification;Molecular;Morphogenesis;Motor;mouse model;mRNA Transcript Degradation;Mus;Mutation;Organogenesis;Outcome;Patients;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;Pregnancy;Process;Proliferating;Proteins;Regulation;Research;ribosome profiling;RNA;RNA Splicing;RNA-Binding Proteins;Role;Severities;Severity of illness;Sex Differences;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;stem cells;Syndrome;Testing;Time;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translational Regulation;translatome;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of RNA-binding protein DDX3X in heart development and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE The cytoskeleton (“cell skeleton”) is crucial for organizing our cells and allowing them to adapt to changing conditions. Proteins called actin nucleation factors are required for assembling the cytoskeleton in processes that maintain cell viability, but how the factors control programmed cell death – apoptosis – is not understood. To discover how the cytoskeleton enables the proper cellular responses to DNA damage, the goal of this research project is to determine how actin nucleation factors interact with proteins that promote apoptosis.

PI_NAMEs: CAMPELLONE, KENNETH G (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;Affect;Apoptosis;Apoptotic;apoptotic protease-activating factor 1;base;Binding;Biochemical;Biogenesis;Biological;biophysical analysis;Biophysics;BIRC4 gene;Bundling;CASP3 gene;Caspase;Caspase Inhibitor;Cell Death;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;Cellular biology;Communication;Complex;Coupling;crosslink;Cytochrome a;cytochrome c;Cytoskeleton;Data;density;Diffuse;Disease;DNA Damage;Ensure;F-Actin;Family member;G Actin;Genetic;Goals;Human;In Vitro;Individual;insight;Interdisciplinary Study;Interphase Cell;Link;Measures;Mediating;Mediator;Microfilaments;Microscopy;Mitochondria;Modeling;Molecular;mutant;Mutate;Outer Mitochondrial Membrane;Paper;Participant;Pathway interactions;Pattern;Polymers;pro-apoptotic protein;Process;Protein Biochemistry;Protein Family;Proteins;Proteolysis;recruit;Research Project Grants;Resistance;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Skeleton;Stress;Structure;Testing;Textbooks;TP53 gene;virtual;Wiskott-Aldrich syndrome protein

PROJECT_TITLE: Cytoskeletal compartmentalization of apoptotic signaling

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative The lack of large and representative data with information on both individual childhood experiences and adult health status by race limits studies on the childhood origins of health and health disparities. The project will overcome existing data limitations via historical records linkages and fill vital knowledge gaps regarding the impacts of childhood environments on longevity and racial disparities. The data constructed from the project will catalyze future studies on aging, demography, and intergenerational studies.

PI_NAMEs: YUE, DAHAI  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adult;Affect;Aging;Area;authority;Birth;Birth Place;Black American;Black Populations;Cardiovascular Diseases;caucasian American;Censuses;Cessation of life;Child;Childhood;Chronic;Cities;cohort;Communicable Diseases;Complement;Country;County;Data;Data Set;Date of birth;Death Rate;Death Records;Demography;Disease;economic outcome;Education;educational atmosphere;Environment;Evaluation;experience;Exposure to;Family;Future;Genealogical Tree;Health;health disparity;Health Policy;Health Status;Immigration;improved;Individual;Inequality;Infection;Inflammation;Influenza;intergenerational;Joints;Knowledge;large datasets;late life;Life;Life Cycle Stages;Life Expectancy;life span;Link;Literature;Location;Long-Term Effects;Longevity;Measures;middle age;mortality;Outcome;Policies;Price;programs;Proxy;Public Health;Race;racial disparity;racial population;Recording of previous events;Records;Research;Research Personnel;Resources;Sampling;school district;Schools;Shapes;socioeconomics;teacher;Testing;Trees;Variant;Wages;Work

PROJECT_TITLE: The effect of childhood environments on adult health and mortality


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Despite intensive research, the etiology leading to neuronal cell loss in Parkinson’s diseases remains unknown. There is compelling evidence that aberrant histone acetylation is implicated in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and related dementias, however there is currently no mechanistic insight about the cause and how dysregulated histone acetylation is functionally linked to the age-related neurodegeneration. This proposal aims to combine pluripotent stem cell-based disease models and patients’ postmortem tissue to systematically dissect the contribution aberrant of histone acetylation in the development of Parkinson’s disease.

PI_NAMEs: SOLDNER, FRANK  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acyltransferase;Adaptor Signaling Protein;Affect;age related neurodegeneration;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Autopsy;biochemical tools;Biological;biological adaptation to stress;Biological Models;Brain;brain tissue;Cell model;Cells;Characteristics;Chromatin;Cognition;Compensation;Complex;CRISPR screen;Data;defined contribution;Development;Disease;disease model;Drug Targeting;Enzymes;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;experimental study;Foundations;gain of function;Gene Expression;Gene Expression Profile;Gene Mutation;gene network;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Histone Acetylation;Histone Deacetylase;histone deacetylase 2;Histone Deacetylase Inhibitor;Histones;Human;human pluripotent stem cell;Impairment;In Vitro;in vitro Model;Induced Neurons;insight;interest;Investigation;Lewy Bodies;Lewy Body Dementia;Link;loss of function;Mediating;Molecular;Multiple System Atrophy;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neuroprotection;neurotoxicity;novel;novel therapeutics;Parkinson Disease;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Patients;PCAF gene;Phenotype;Physiological;Play;Pluripotent Stem Cells;Protein Acetylation;protein degradation;Proteins;Proteomics;Research;restoration;Reverse Transcription;Role;SAGA;small molecule;small molecule inhibitor;synucleinopathy;System;Techniques;Testing;Therapeutic;Tissue Sample;Tissues;tool;Toxic effect;Translations

PROJECT_TITLE: The Role of Aberrant Histone Acetylation in the Pathogenesis of Parkinson’s Disease and Related Synucleinopathies.

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Hypothyroidism is a common condition, more frequent in females, associated with excess of cardiovascular risk and poor quality of life not completely abrogated by treatment with levothyroxine. There is an unmet need to define a safe, effective, and feasible regimen to be applied in large trials aimed at assessing levothyroxine/liothyronine combination therapy in patients living with hypothyroidism. To address this knowledge gap we propose a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study whose results will lay the foundation of large multicenter trial(s) able to demonstrate the effectiveness (or lack thereof) of levothyroxine/liothyronine combination therapy.

PI_NAMEs: CELI, FRANCESCO S (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Adherence;Affect;Animal Model;arm;Body Weight;cardiovascular risk factor;Cardiovascular system;Cholesterol;Clinical;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Combined Modality Therapy;Compensation;Data;Desiccation;Disease;dosage;Dose;Double-Blind Method;Effectiveness;Female;Foundations;Frequencies;Genes;Genetic Polymorphism;Half-Life;Hormonal;hormonal signals;Hypothyroidism;improved;In Vitro;indexing;instrument;Iodide Peroxidase;Knowledge;LDL Cholesterol Lipoproteins;lipid metabolism;Logistics;Mission;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;non-genomic;novel;novel therapeutic intervention;Organ;Participant;Patients;Peripheral;pharmacokinetics and pharmacodynamics;Pilot Projects;Population;preference;prevent;Quality of life;Randomized;Recommendation;recruit;Regimen;Research Design;response;Role;Safety;safety assessment;Scheme;Serum;Testing;Therapeutic;Therapeutic Trials;Therapy Clinical Trials;Thyroid Extract;Thyroid Gland;Thyroid Hormones;Thyroidectomy;Thyroxine;Tissues;Toxic effect;Treatment Efficacy;Triiodothyronine;Weight

PROJECT_TITLE: New Approaches for the treatment of Hypothyroidism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project narrative The translational strength of the proposal is the clear path to, eventually, clinical testing. We have already identified some FDA approved drugs that, after optimization, can be repositioned for the treatment of tRCC. We expect that these studies will provide also the identification and optimization of additional new small molecule inhibitors suitable for therapeutic interventions in tRCC.

PI_NAMEs: PILI, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: 6p21;Acceleration;Adult;Aggressive behavior;antitumor effect;Binding;Biological;Biological Assay;Biological Availability;Biological Testing;Cells;Chimeric Proteins;Chromosomal Rearrangement;Clinical;Computer Assisted;Data;dimer;Dimerization;Disease;Docking;Drug Design;FDA approved;fexofenadine;Fluorescence Resonance Energy Transfer;Gene Fusion;Generations;Genes;Genetic Transcription;Histologic;Homo;Homology Modeling;Human;in vitro Model;in vivo;Incidence;innovation;insight;knock-down;Lead;lead optimization;Length;Leucine Zippers;lipophilicity;Malignant childhood renal neoplasm;microscopic imaging;Modeling;Monitor;Mutation;new therapeutic target;novel;novel therapeutics;Oncogenic;Oral;Outcome;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Play;Positioning Attribute;Prevalence;Proliferating;Property;protein protein interaction;Proteins;Renal Carcinoma;Renal Cell Carcinoma;research clinical testing;Role;scaffold;small molecule;small molecule inhibitor;Structure-Activity Relationship;targeted treatment;Testing;TFE3 gene;Therapeutic Intervention;therapeutic target;Time;tool;Translating;tumorigenesis;Xp11.2

PROJECT_TITLE: Therapeutic targeting for translocation renal cell carcinoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]