NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Sleep Research;Substance Misuse;Underage Drinking

PHR: PROJECT NARRATIVE Alcohol and cannabis misuse are associated with significant harm in young adult populations, including all three leading causes of death (accidents, suicide, homicide). Sleep impairment is also common and costly among young adults, and research indicates significant comorbidity among alcohol misuse, cannabis misuse, and sleep impairment with evidence of bidirectional causal relationships that can exacerbate related harms. The current application uses a rigorous and efficient trial design to test an integrated brief alcohol, cannabis, and sleep intervention in comparison to two monotherapies (for alcohol/cannabis misuse and for sleep) to address this important and often overlooked comorbidity among young adults.

PI_NAMEs: LARIMER, MARY E. (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Accidental Injury;Accidents;Address;Adolescent;alcohol comorbidity;alcohol consequences;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohols;attentional control;automobile accident;Automobile Driving;Behavior Therapy;binge drinking;Body mass index;brief alcohol intervention;Brief Alcohol Screening and Intervention for College Students;brief intervention;brief motivational intervention;Cannabis;Cause of Death;Cessation of life;Cognitive Therapy;college;Communities;Comorbid Insomnia;comorbidity;comparative efficacy;cost;Data;Decision Making;Development;diaries;Distress;drinking;Drowsiness;efficacy evaluation;experience;Fatigue;follow-up;Frequencies;Health;high risk;Homicide;Hour;Impairment;improved;improvement on sleep;indexing;Intervention;intervention effect;Link;Literature;marijuana use;marijuana use disorder;Measures;Mediating;Mediator;Mental Health;Modeling;National Institute on Alcohol Abuse and Alcoholism;older adult;Outcome;Participant;physical conditioning;poor sleep;Population;Prevention program;Primary Insomnia;Public Health;Randomized;reduced alcohol use;reduced substance use;Relapse;Reporting;Research;Resources;Risk;Risk Factors;Sample Size;Sampling;Severities;sex;Sleep;sleep difficulty;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;sleep regulation;Sleeplessness;Students;substance use;success;Suicide;Surveys;Symptoms;telehealth;Testing;therapy development;Time;trial design;Work;young adult;young adult alcohol use

PROJECT_TITLE: Efficacy of Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed research is aimed at engineering a novel longitudinally-detected electron paramagnetic resonance system for inexpensively and noninvasively quantifying iron oxide nanoparticles in tissues. This system will be used to determine concentrations of nanoparticles in rat kidneys that have been cryopreserved for transplantation. The measurements from this system will be used to address bottlenecks in kidney cryopreservation research, thus increasing the number and quality of kidneys available for transplant.

PI_NAMEs: KANTESARIA, SAURIN  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Abdomen;Address;Amplifiers;Behavior;career;Complex;cost;Coupled;cryogenics;Cryopreservation;Cryoprotective Agents;Data;Detection;detection limit;Diagnostic Imaging;Dimensions;Electron Spin Resonance Spectroscopy;Electrons;Engineering;Ensure;Foundations;Free Radicals;Frequencies;Goals;Heating;Ice;Image;imaging capabilities;imaging modality;imaging system;improved;interest;Iron;iron oxide nanoparticle;Kidney;kidney biopsy;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Mass Spectrum Analysis;Measurement;Measures;Methods;microCT;Monitor;nanoparticle;nephrogenesis;Noise;novel;Nuclear Magnetic Resonance;Organ;particle;particle counter;Perfusion;Physicians;Physics;post-transplant;prevent;Process;Property;Protocols documentation;radio frequency;radiologist;Rattus;Reproducibility;Research;Resolution;Rewarming;Rotation;Sampling;Signal Transduction;Solid;success;System;Techniques;Temperature;Tissues;Toxic effect;translation to humans;Translations;transmission process;Transplantation;X-Ray Computed Tomography

PROJECT_TITLE: Quantification of Iron Oxide Nanoparticles in Cryopreserved Kidneys with Longitudinally Detected Electron Paramagnetic Resonance

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neurons rely on proper control of gene expression to make appropriate connections during development and to mediate experience-dependent plasticity and memory formation. These gene-expression pathways are tuned by microRNAs (miRNAs), short RNA molecules that modulate gene expression by targeting mRNAs for translational repression and degradation. This proposal will address how neuronal miRNAs themselves are governed, thereby opening a new window into the mechanisms underlying neurological disorders that arise due to mis-regulation of neuronal gene expression.

PI_NAMEs: FRANK, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adult;Affect;Animal Behavior;animal data;Brain;Brain region;Calcium;candidate identification;Cell Adhesion Molecules;cell fate specification;Cell Nucleus;cell type;Cells;crosslinking and immunoprecipitation sequencing;Data;Degradation Pathway;Dendritic Spines;Development;Disease;Exhibits;experience;experimental study;flexibility;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Human;human induced pluripotent stem cells;Image;insight;Ion Channel;Link;Mammals;Mediating;Memory;Messenger RNA;MicroRNAs;Modeling;Morphology;mRNA Translation;Mus;Mutant Strains Mice;Mutation;Nervous System;Nervous System Disorder;neural;neural circuit;Neurobiology;neurodevelopment;neuron development;neuronal excitability;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurotransmitters;Pathway interactions;Physiological;Physiology;Play;Post-Transcriptional Regulation;posttranscriptional;Prevalence;Production;Property;Proteins;recruit;Regulation;Regulatory Pathway;response;RNA;Role;Shapes;Slice;Synapses;Synaptic plasticity;Testing;Translational Repression;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Mechanisms governing post-transcriptional regulation of neuronal microRNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Neuroinflammation is a hallmark of brain aging and neurodegenerative diseases such as Alzheimer’s and may serve both protective and pathogenic roles. We have identified a highly consistent microglial induction of Major Histocompatibility Complex I (MHC-I) and paired immunoglobulin receptors families with age and AD in mouse and man. This project will explore the hypothesis that MHC-I signals non-canonically (e.g., non-T cell receptor mechanisms) to regulate microglial reactivity with aging and Alzheimer’s.

PI_NAMEs: KELLOGG, COLLYN MICHAEL (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Age;age related;Age-associated memory impairment;age-related disease;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Antigens;Behavior;behavior test;Behavioral;behavioral outcome;Biochemical;Brain;brain cell;brain health;career;Cells;Clinical;clinical practice;cognitive function;Data Science;design;Development;Disease;disease phenotype;Disease Progression;Elderly;experience;Family;Fellowship Program;Flow Cytometry;Future;Genes;Gliosis;healthspan;Human;Immune;Immune response;Immune system;immunoglobulin receptor;Immunoglobulins;improved;Inflammaging;Inflammation;Inflammatory;insight;interest;ITAM;ITIM;Knock-in;Knock-out;Knockout Mice;Laboratories;Leukocytes;Life Expectancy;LoxP-flanked allele;Macrophage;Major Histocompatibility Complex;man;Measures;Methods;Microglia;Modeling;Molecular Analysis;molecular phenotype;Morphology;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroimmune;neuroinflammation;Neurologist;neuropathology;Neurosciences;novel;Onset of illness;Organ;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peripheral;Phagocytes;Phenotype;prevent;Prevention;Proliferating;receptor;Regulation;Research;response;Role;Senile Plaques;Severity of illness;Signal Transduction;skills;Sterility;Symptoms;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;Time;training opportunity;translatome;trend;Up-Regulation;Validation;Virus;Work

PROJECT_TITLE: Regulation of Microglial Function by Major Histocompatibility Complex I in Aging and Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Kidney resident macrophages (KRM) are known accelerators of ADPKD as their depletion slows cyst progression. In this application, I will study the kinetics and mechanism of KRM niche filling after temporary depletion in an ADPKD mouse model to identify possible means to achieve long-term, kidney specific resident macrophage depletion. This work may provide a template to develop long-term, tissue specific, resident macrophage depletion in the kidney, something that will be of broad interest to the macrophage and kidney community.

PI_NAMEs: YASHCHENKO, ALEX  (contact)

PROJECT_TERMS: Acceleration;Adoptive Transfer;Affect;Autosomal Dominant Polycystic Kidney;Bone Marrow;Candidate Disease Gene;Clinical;Communities;Cyst;Cystic Kidney Diseases;Data;data exchange;Development;Disease;disease model;Disease Progression;DNA Sequence Alteration;emerging adult;End stage renal failure;Engraftment;experience;Flow Cytometry;Genes;Goals;Growth;Histologic;Human;Immune;Immunofluorescence Microscopy;Immunology;indexing;Inherited;interest;Intervention;Kidney;Kidney Diseases;Kinetics;Life;Ligands;Liquid substance;Literature;LoxP-flanked allele;Macrophage;Maps;monocyte;mouse model;Mus;Nature;Nephrology;novel strategies;Organism;Patients;Persons;pharmacologic;Population;Process;Proliferating;Publishing;Receptor Signaling;recruit;Renal function;Role;Sampling;single-cell RNA sequencing;Specificity;Stromal Cells;Symptoms;Testing;Tissues;Work

PROJECT_TITLE: Targeting kidney resident macrophage niche filling to slow cystic kidney disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Research Narrative Investigating the neural mechanisms of anxiety and behavioral responses to danger is essential to understanding the pathology of anxiety-related disorders and developing novel treatments for these afflictions. This proposal will describe DRN projections and serotonergic receptors in the insula using innovative viral-genetic tracing methods, visualize insular serotonin activity in response to danger signals using in vivo fiber photometry, and manipulate the DRN-insula tract during exposures to danger signals using chemogenetic techniques.

PI_NAMEs: NG, ALEXANDRA JADE (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Affect;Affective;Aggressive behavior;Agonist;Amygdaloid structure;Anatomy;antagonist;Anti-Anxiety Agents;Anxiety;anxiety states;anxiety treatment;anxiety-related behavior;anxiety-related disorders;anxious behavior;Area;Arousal;Automobile Driving;Basic Science;Behavior;behavior influence;behavior prediction;behavior test;Behavioral;behavioral response;Biological;Boston;Cannulas;cell type;college;Cues;Dangerousness;Data;Data Analyses;design;Development;Disease;dorsal raphe nucleus;effective therapy;Environment;Enzymes;Equipment;excitatory neuron;experience;Exposure to;Extinction;Faculty;Female;Fiber;Fluorescence;Foundations;Fright;Future;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic;genetic approach;Genetic Techniques;Glutamates;Goals;Human;Hyperactivity;Immunohistochemistry;Impairment;improved;In Situ Hybridization;in vivo;in vivo imaging;inhibitory neuron;innovation;Insula of Reil;Interoception;Knock-out;knowledge base;Label;Learning;Link;male;Mammals;Measures;Methods;motivated behavior;multisensory;Neurobiology;neuroimaging;neuromechanism;Neurons;Neurosciences;Neurotransmitter Receptor;novel;novel therapeutics;Pain;Pathology;Perception;Phenotype;Photometry;Population;Positioning Attribute;postsynaptic;postsynaptic neurons;preference;programs;promoter;Prosencephalon;Psychopathology;Rattus;Reaction;receptor;Receptor Activation;Research;Research Personnel;Research Proposals;Research Training;response;Safety;Scientist;sensor;Serotonin;Serotonin Receptor 5-HT2C;Shock;Signal Transduction;skill acquisition;skills;social;Social Behavior;social bias;social engagement;Source;Stimulus;Stress;Synapsins;System;Technical Expertise;Techniques;Testing;Tissues;Tracer;Training;Translational Research;Viral Vector;virus genetics;Visualization;Withdrawal

PROJECT_TITLE: Insular serotonin modulatesbehavioral responses to danger

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Disease

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE  Chronic hepatitis B virus infection (CHB) causes almost 1 million deaths annually through chronic liver injury, liver failure, and primary liver cancer. These outcomes can be prevented by clearance of the hepatitis B surface antigen (HBsAg), a clinical cure that is rarely achieved with existing antiviral therapies. Using cross-species analyses of a mouse model that recapitulates human age-dependent differences in hepatitis B virus response and data from an antiviral therapy withdrawal clinical trial, I propose to unravel mechanisms that underpin immune-mediated termination of CHB and identify actionable targets for interventions that change the hepatic immune environment to promote clinical cure.

PI_NAMEs: CAREY, NICHOLAS DANIEL (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Acute Hepatitis;Adult;Age;age difference;age related;Agonist;analog;Anti-viral Therapy;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;attributable mortality;B-Lymphocytes;Biological;Biological Assay;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cessation of life;Child;Chronic Hepatitis B;chronic infection;chronic liver injury;Cirrhosis;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Coculture Techniques;cohort;Cytometry;Data;Defect;Dendritic Cells;Diagnosis;differential expression;draining lymph node;end stage liver disease;Environment;experimental study;Fatal Outcome;Flow Cytometry;Frequencies;Gene Expression;Genes;Goals;Hepatic;Hepatic Tissue;Hepatitis B;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatocyte;Human;Image;Immune;Immune response;Immune system;Immunity;Immunohistochemistry;Immunologics;immunoregulation;In Vitro;in vitro Assay;in vivo;Infection;insight;Intervention;Investigation;Laboratories;Licensing;Life;Liver;Liver Failure;liver injury;Liver parenchyma;Mediating;Monoclonal Antibodies;mouse model;Mus;neonate;next generation;Outcome;Pathway interactions;Patient Participation;Patients;Persons;Pharmaceutical Preparations;Phenocopy;Population;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Publishing;Relapse;Research;response;Role;secondary lymphoid organ;Serology;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;Source;Spleen;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TNFRSF5 gene;TNFSF4 gene;trafficking;transcriptomics;Transgenic Mice;Viral;Virus;Virus Diseases;Withdrawal;Work

PROJECT_TITLE: Hepatic Priming of CD4+ T cells Directs Effective Hepatitis B Virus Immunity

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Adherence to antiretroviral therapy is vital for prevention of AIDS-related deaths and comorbidities in children living with HIV, but pediatric populations face greater challenges to adherence compared to adults including difficulties with medication tolerability. Pediatric trials and evidence generated from these trials have lagged behind adult trials, especially in regard to use of modern causal inference methods to address analytic challenges. This proposal will use data from a pediatric randomized trial of dolutegravir-based ART compared to standard of care and novel epidemiologic methods to demonstrate how to improve evaluation of evidence generated from pediatric trials.

PI_NAMEs: LI, CATHERINE XIN-DI (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 15 year old;19 year old;2 year old;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adult;Adverse event;Affect;Age;aged;AIDS prevention;antiretroviral therapy;Caregivers;Cessation of life;Characteristics;Child;Childhood;Clinical;Clinical Medicine;cohort;Combined Modality Therapy;comorbidity;Data;Deglutition;dosage;Dose;drug efficacy;efficacious treatment;efficacy evaluation;Epidemiologic Methods;Evaluation;Face;Failure;follow-up;Formulation;Future;Guidelines;HIV;Human immunodeficiency virus test;implementation framework;improved;Infant;Infant Mortality;International;Intervention;Leadership;Letters;liquid formulation;Machine Learning;medication compliance;medication nonadherence;Methods;model building;Modernization;novel;Nucleosides;Nucleotides;off-label use;open label;Pattern;pediatric human immunodeficiency virus;Pediatrics;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Physicians;pill;Population;prevent;Probability;Productivity;Protocols documentation;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;response;Reverse Transcriptase Inhibitors;Sample Size;Sampling;Scientist;skills;standard of care;Taste Perception;Therapeutic;therapy adherence;Time;tool;Training;treatment adherence;treatment effect;Treatment Failure;United States Food and Drug Administration;Work

PROJECT_TITLE: Characterizing adherence and estimating per-protocol effects for pediatric dolutegravir use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-H (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Understanding neutrophil development and the regulation of their effector functions is essential for advancing treatments of various infectious and sterile inflammatory diseases. The goal of this proposal is to gain comprehensive insights into the functional significance of PSTPIP2 in neutrophil biology. The outcomes of this research will advance our understanding of the innate immune regulations by defining the role of PSTPIP2 in granulopoiesis and also determine its contribution to neutrophilic defenses against Pseudomonas aeruginosa.

PI_NAMEs: RATITONG, BRIDGET  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Actins;Address;Affect;amphiphysin;arm;autoinflammatory;autoinflammatory diseases;Behavior;Binding;Biological Assay;Biology;Blood;bone;Bone Marrow;Cells;Chronic;Circulation;cytokine;Cytoplasmic Granules;Cytoskeleton;Data;Development;Disease;Emergency Situation;Equilibrium;Exhibits;extracellular;Family;Flow Cytometry;Frequencies;Gene Expression Profile;Generations;Global Change;Goals;granulocyte;granulocyte-monocyte progenitors;Granulopoiesis;Health;Hematopoietic stem cells;Human;Hyperactivity;Immunology;immunoregulation;improved;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interleukin-1 beta;Knowledge;Lead;Leukocytes;Light;Lung infections;Macrophage;Measures;Membrane;migration;Missense Mutation;Modeling;monocyte;Mus;Myeloid Progenitor Cells;Neutropenia;neutrophil;Neutrophilia;novel;Osteomyelitis;Outcomes Research;Pathogenesis;Phagocytosis;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Play;Population;Process;progenitor;Proline;Property;Protein Serine/Threonine Phosphatase;Proteins;Pseudomonas aeruginosa;Reactive Oxygen Species;recurrent infection;Regulation;Research;response;Role;single-cell RNA sequencing;Site;Source;Spleen;stem cell differentiation;stem cells;Sterility;Stimulus;targeted treatment;TRIP10 gene;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: Defining the role of PSTPIP2 in neutrophil biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: HL

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Stroke

ORG_CITY: NEW ORLEANS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Hereditary Hemorrhagic Telangiectasia (HHT), a blood vessel disorder that can be passed from parents to children, affects about 1 in 5000 people worldwide. In HHT, enlarged shunts (arteriovenous malformations, AVMs) and entangled surface-level vessels (telangiectasias) form and can bleed, causing anemia, stroke, and even death. The goal of this project is to develop a more effective mouse model to understand the mechanisms underlying AVM formation in HHT.

PI_NAMEs: GUIDROZ, ADELLA PATIENCE BOUDREAUX (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: activin receptor-like kinase 1;ACVRL1 gene;Adult;Affect;Alleles;Anemia;angiogenesis;Area;Arteries;Arteriovenous malformation;Biological;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;brain arteriovenous malformations;Bypass;capillary bed;Cells;Cerebrovascular system;Cerebrum;Cessation of life;Child;Clonal Expansion;Collaborations;Communication;Complication;Coupled;Data;Development;Diagnosis;DNA;Dose;Endoglin;Endothelial Cells;ENG gene;Epistaxis;experience;Experimental Designs;Extravasation;Eye;functional loss;Gene Expression;Gene Mutation;Germ Lines;Germ-Line Mutation;Goals;Hemorrhage;Hereditary hemorrhagic telangiectasia;Heterozygote;Individual;inducible Cre;innovation;Knock-out;Lead;Learning;Lesion;Life;Liver;loss of function;loss of function mutation;Loss of Heterozygosity;Lung;malformation;Modeling;Molecular Profiling;mosaic;mosaic loss;mouse model;Mucous Membrane;Mus;mutant;Mutate;Mutation;neurovascular;novel;novel strategies;Nutrient;Organ;Oxygen;Parents;Pathogenicity;Pathology;Patients;Persons;Phenotype;Population;Positioning Attribute;postnatal;Problem Solving;Proteins;Rare Diseases;rare genetic disorder;Recurrence;Research;Research Institute;Retina;retina blood vessel structure;Role;Rupture;Scientist;Severities;Shunt Device;Signal Transduction;Site;skills;Skin;Somatic Mutation;Stimulus;Stroke;Surface;Tamoxifen;targeted treatment;Techniques;Telangiectasis;tenure track;Testing;Therapeutic Research;tool;Training;transcriptomic profiling;transcriptomics;Transforming Growth Factor beta;Variant;vascular bed;Vascular Diseases;Veins;wound

PROJECT_TITLE: EVALUATING THE IMPACT OF LOSS OF HETEROZYGOSITY ON LOCALIZED AVM FORMATION IN HHT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MILWAUKEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Adaptive optics (AO) imaging represents a powerful instrument for the assessment of ocular diseases and disorders, as well as a means for diagnostic and therapeutic evaluation. Despite its advantages, this method has many mechanical and logistic limitations; this project aims to increase the image quality and general accessibility of AO imaging to a broader patient population. The training environment is ideally suited to support this aim, develop my personal engineering skills, as well as encourage my growth as an independent scientist.

PI_NAMEs: WOEHLKE, RUTH E (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Abbreviations;Acceleration;adaptive optics;arm;Assessment tool;Biological Markers;Blood Vessels;Cataract;Cells;Clinical;clinical application;Clinical Trials;Columbidae;Communities;Conceptions;Cone;contrast enhanced;Cornea;cost;Custom;Data;design;Detection;Development;Devices;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic tool;Diameter;digital;Disease;Disease Progression;Elements;Engineering;Environment;Eye;Eye diseases;Foundations;Future;General Population;Goals;Growth;Human;Image;imaging detection;Imaging Device;imaging modality;improved;in vivo;in vivo imaging;in vivo monitoring;Individual;instrument;Knowledge;Lateral;lens;Lens Opacities;Lesion;Light;light intensity;light scattering;Lighting;Logistics;manufacture;Masks;Mathematics;Mechanics;Medical;Methods;Modality;Modeling;Modification;Myopia;Ophthalmology;Ophthalmoscopes;Ophthalmoscopy;optical imaging;Optics;Pathology;Pathway interactions;patient population;Performance;Phase;Photoreceptors;Population;Population Heterogeneity;Population Study;Pregnant Women;prevent;Process;Property;Research;Research Personnel;Resolution;Retina;Retinal Diseases;retinal imaging;Rod;Rotation;Scanning;Scientist;Screening procedure;Shapes;skills;software development;Structure;System;Systemic disease;Systems Integration;Techniques;therapeutic evaluation;tool;Training;training opportunity;visual performance;Visualization;Work

PROJECT_TITLE: Expanding the Accessibility and Quality of Ophthalmic Imaging through Optical Elements and Modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Emerging Infectious Diseases;Health Services;Infectious Diseases;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Urologic Diseases

PHR: Project Narrative Urinary tract infections (UTIs) are the most common infection during pregnancy. Despite this, there is insufficient evidence comparing the safety and effectiveness of the different antimicrobial treatment options. The proposed project will clarify choices between the most common treatments and it will develop tools for future researchers to investigate similar questions.

PI_NAMEs: KAHRS, JACOB  (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Adverse event;algorithm development;Algorithms;Antibiotics;antimicrobial;Antimicrobial Resistance;Attention;Bacteriuria;career;Classification;Clinical;clinical care;Clinical Data;Code;Cohort Studies;common treatment;comparative effectiveness;Comparative Effectiveness Research;Data;Data Set;Data Sources;Databases;demographics;Diagnosis;doctoral student;Effectiveness;Electronic Health Record;Enrollment;Environment;Epidemiology;Ethnic Origin;Evaluation;Fellowship;Future;Guidelines;Health system;Healthcare;Healthcare Systems;Heterogeneity;Individual;Infection;innovation;insurance claims;kidney infection;Laboratories;Low Birth Weight Infant;Manuals;Medicaid;Medical;Mentors;Minor;North Carolina;Outcome;Output;pathogen;Patients;perinatal outcomes;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Population;pre-doctoral;Pregnancy;pregnant;Premature Birth;Prevalence;Privatization;Procedures;programs;Provider;Public Health;Race;Recommendation;Records;Research;Research Personnel;Risk;Safety;Sepsis;Spontaneous abortion;stillbirth;Symptoms;Techniques;Testing;tool;Training;Treatment Effectiveness;Treatment Protocols;United States;Universities;urinary;Urinary tract infection;Urine

PROJECT_TITLE: Comparison of Antimicrobial Safety and Effectiveness for the Treatment of Urinary Tract Infections During Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE This project is focused on autosomal dominant polycystic kidney disease (ADPKD), which is mostly caused by reduced polycystin-1 or polycystin-2. Numerous evidence suggests that the normal functionality of polycystins requires them to be positioned in cilia and the reduced functional dosage of polycystins triggers compartmentalized increase of cAMP and PKA activity in cilia to initiate ADPKD; however, how the ciliary trafficking and function of polycystins are regulated remains vague. The major goals of the proposed studies are: (1) dissecting the ciliary modules that mediate the targeting of polycystins into cilia and (2) understanding how polycystins maintain the homeostasis of cAMP and PKA activity in primary cilia.

PI_NAMEs: HARRIS, PETER C.;LING, KUN  (contact)

PROJECT_TERMS: A kinase anchoring protein;Address;Adult;Affect;Age;Age Years;Alleles;Autosomal Dominant Polycystic Kidney;base;Biosensor;Cell model;Cilia;ciliopathy;Compensation;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cystic kidney;Data;Defect;Dialysis procedure;Diffusion;Disease;Disease Progression;Docking;dosage;Epithelial Cells;FDA approved;Fluorescence Microscopy;functional loss;G-Protein-Coupled Receptors;gain of function;gene editing technology;Genetic Diseases;Goals;Homeostasis;In Vitro;Inherited;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Kidney Transplantation;kinetosome;Light;Link;Lipids;Live Birth;live cell imaging;loss of function;Mediating;Membrane;Molecular;Mus;Mutation;new therapeutic target;novel;Organelles;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phosphotransferases;Physiology;PKD1 gene;PKD2 gene;PKD2 protein;polycystic kidney disease 1 protein;Polycystic Kidney Diseases;Positioning Attribute;prevent;Production;Proteins;Publishing;recruit;Recruitment Activity;renal epithelium;Research;Role;Sensory;Severities;side effect;Signal Transduction;Structure;Testing;therapeutically effective;tolvaptan;trafficking;Transportation;ultra high resolution;Vesicle

PROJECT_TITLE: Investigate the trafficking and function of polycystins in primary cilia and their implications for polycystic kidney disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health;Violence Research;Women's Health Research

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The U.S. is a global leader in the incidence of major depressive disorder (MDD), a common, often recurring mental health problem associated with lifelong health implications; however, current available treatments do not provide adequate relief for a large portion of those affected. The proposed project will seek to understand how childhood maltreatment, which is a major risk factor for the development of MDD in adulthood, as well as an overall worse course of illness, “gets under the skin” to affect inflammation signaling. I will explore the effects of childhood maltreatment on inflammation and MDD from adolescence into middle adulthood using a nationally representative U.S. sample, devoting specific attention to the roles of sex and gender differences.

PI_NAMEs: O'SHIELDS, JAY DAVID (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Applied Research;Attention;Behavior;Categories;Child Abuse and Neglect;Cohort Studies;Complex;Data;Data Set;depressive symptoms;deprivation;design;Development;Diabetes Mellitus;disability risk;early onset;effective therapy;Equipment and supply inventories;experience;Female;Gender;gender difference;Gender Role;Goals;Guidelines;Health;Heart Diseases;high risk;Human;Immune system;improved;Incidence;Income;Individual;Inflammation;inflammatory marker;Intervention;life span;Link;Longitudinal Studies;Major Depressive Disorder;male;Malignant Neoplasms;meetings;Mental Health;Methods;middle age;Modeling;Morbidity - disease rate;National Longitudinal Survey of Adolescent to Adult Health;neglect;novel;Peer Review;Persons;physical conditioning;Population;Prevention strategy;Recommendation;Recording of previous events;Recurrence;Reproducibility;Research;Risk Factors;Role;Sampling;sex;Sex Differences;Signal Transduction;Skin;suicidal risk;Symptoms;Testing;theories;Training;Treatment Efficacy;treatment strategy;Up-Regulation;women versus men

PROJECT_TITLE: Exploring the Effects of Childhood Maltreatment on Inflammation and Major Depression: From Adolescence to Middle Adulthood


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Genetics

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Cold Spring Harbor Laboratory Conference GENE EXPRESSION AND SIGNALING IN THE IMMUNE SYSTEM  April 16-20, 2024 PROJECT NARRATIVE The immune system provides the body’s major defense against both infectious diseases and cancer. It employs a wide variety of strategies to recognize and remove microbes and distressed cells, as well as providing the protective immunity against future infections that forms the basis of vaccination. The immune system may also respond aberrantly or too aggressively, as in various forms of allergy, or may attack the body’s own cells, as in autoimmune diseases. The cells of the immune system have to interpret a wide variety of signals to respond in an appropriate manner to a given challenge. How these signals are received, transmitted, and interpreted forms the scope of this important conference series. The series is notable because it attracts a unique group of immunologists focused on genes and their mechanisms of action whose research is at the cutting edge in defining how the immune system functions.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: American;Animals;Antigen Receptors;Applications Grants;Area;Autoimmune Diseases;Autoimmunity;Bacteria;Biochemistry;Biological Models;career development;Cell Physiology;cell type;Cells;Clinical Data;Collaborations;Communicable Diseases;Communication;Congresses;Crystallography;cytokine;Data;Development;Discipline;Disease;Distress;Ensure;Environment;Event;Evolution;Faculty;field study;Financial Support;Fostering;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;graduate student;host-microbe interactions;Human;Hypersensitivity;Immune;Immune response;Immune system;immune system function;Immunity;Immunobiology;immunodeficiency;Immunologic Memory;Immunologist;Immunology;Industrialization;Infection;intercellular communication;interest;International;Investigation;Knowledge;Laboratories;Link;Malignant Neoplasms;meetings;Membrane;Microbe;Microbiology;model organism;Molecular;Molecular Analysis;Molecular Biology;multidisciplinary;National Institute of Allergy and Infectious Disease;Natural Immunity;Oral;Participant;pathogen;Pharmacology;Physiology;Postdoctoral Fellow;posters;Process;Productivity;Recording of previous events;Regulation;Research;Research Institute;Research Personnel;Running;Scientist;senior faculty;Series;Signal Transduction;structural biology;success;symposium;Systems Biology;T-Lymphocyte;Time;Tissues;Transcriptional Regulation;transmission process;Vaccination;virology;Virus;Woman;Work

PROJECT_TITLE: CSHL 2024 Gene Expression & Signaling in the Immune System Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Microbiome;Pancreatic Cancer;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Gut microbiome modulation alters the repertoire of gut microbiome derived antigens that traverse from the gut to the liver and has been shown to augment anti-tumor immunity in pancreatic cancer liver metastasis (PCLM). Mucosal associated invariant T (MAIT) cell are a unique subset of invariant T cells which can be modulated to switch from a “pro-tumor” MAIT17 phenotype (suppresses cytotoxic cells) to an “anti-tumor” MAIT1 phenotype (activates cytotoxic cells) by specific activation pathways induced by microbial derived antigens. The goal of this project is to harness the gut microbiome to modulate MAIT cells in the PCLM tumor microenvironment towards a MAIT1 phenotype to promote anti-tumor immunity and reduce PCLM tumor burden.

PI_NAMEs: TOOR, JUGMOHIT  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;antagonist;Antibiotic Therapy;Antibiotics;Antigen Presentation;Antigen-Presenting Cells;Antigens;Bacteria;career;Cell Culture Techniques;Cells;Classification;clinical training;Cultured Cells;cytokine;Cytometry;Data;Diagnosis;exhaustion;experience;fecal microbiome;fecal transplantation;Flow Cytometry;Gene Proteins;Goals;gut bacteria;gut microbiome;gut microbiota;Human;IL17 gene;IL2RB gene;Image;Institution;Interdisciplinary Study;interleukin-12 receptor;interleukin-18 receptor;Knockout Mice;Knowledge;Ligands;Link;Liver;Liver diseases;Malignant neoplasm of pancreas;Mediating;Membrane Proteins;Mentorship;metagenomic sequencing;Metastatic Neoplasm to the Liver;Microbe;microbial;microbiome;microbiome composition;mouse model;Mucous Membrane;Mus;Natural Killer Cells;neoplastic cell;Operative Surgical Procedures;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phenotype;Portal vein structure;protein expression;Proteins;PTPRC gene;Research;Research Training;Riboflavin;sham surgery;Shotguns;single-cell RNA sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Tissues;Toll-like receptors;Training;Travel;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;tumorigenesis;Weight

PROJECT_TITLE: Investigating the MAIT cell- Microbiome Relationship in Pancreatic Cancer Liver Metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Gastric cancer is the fourth leading cause of cancer deaths worldwide and develops through a series of stages in the stomach lining, including SPEM cell-containing metaplasia. Our lab has identified a significant upregulation of the transcription factor SOX9 in SPEM cells, which are essential to the progression of gastric carcinogenesis. Identifying the role of SOX9 in SPEM cells and their contribution to carcinogenesis will move the field forward by discovering and understanding the mechanisms of gastric cancer development.

PI_NAMEs: GUENTHER, ALEXIS A (contact)

PROJECT_TERMS: Acute;Adenocarcinoma;adult stem cell;Alleles;Apoptosis;Apoptotic;Appearance;base;Biological;Cancer Etiology;carcinogenesis;carcinogenicity;Cell Fate Control;Cell Lineage;cell type;Cells;Cessation of life;Chief Cell;Chronic;chronic infection;Cleavage Under Targets and Release Using Nuclease;Data;Development;Diagnosis;Disease;Dysplasia;Enzyme Precursors;experimental study;Fibroblasts;follow-up;gastric cancer prevention;gastric carcinogenesis;Gastric Chief Cells;Gastric Glands;gastric secretion substance;Gastric Tissue;Gene Expression;Genes;Genetic Transcription;Gland;Helicobacter Infections;Helicobacter pylori;Histologic;Human;human tissue;Immune;Immunofluorescence Immunologic;In Vitro;Inflammation;Injury;Intestines;Knock-out;Knockout Mice;Lesion;Light;malignant stomach neoplasm;Metaplasia;Metaplastic Cell;Modeling;Molecular;Morphology;mouse model;Mucous Membrane;Mus;Normal Cell;novel;Oncogenes;Organoids;Persons;Phenotype;Process;Proteins;Recovery;recruit;Research;Role;Series;Small Intestines;spasmolytic polypeptide;Stains;stem cell differentiation;stem cell population;stem cells;Stomach;Structure;success;Testing;therapeutic target;Time;Tissue Sample;Tissues;transcription factor;transcriptomic profiling;transdifferentiation;Transgenic Mice;Transgenic Organisms;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: SOX9 as a key transcriptional regulator of SPEM cells in gastric carcinogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE While malaria control efforts have focused on other species, infections by Plasmodium ovale spp. are more common than previously thought and rising in prevalence in sub-Saharan Africa. This proposal aims to employ genomic and epidemiological methods to characterize the parasite population and determine relapse patterns of this neglected malaria parasite. The foundational knowledge gained will inform relapse treatment guidelines and provide essential genomic details for future research and surveillance of ovale malaria.

PI_NAMEs: CAREY-EWEND, KELLY  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Academia;Africa;Africa South of the Sahara;African;Age;Area;Base Pairing;Behavior;biomarker identification;Blood specimen;burden of illness;career;Caring;Central Africa;Child;Clinical;Clinical Clerkship;Clinical Research;co-infection;cohort;Collection;Communicable Diseases;Competence;Country;Data;Demographic Factors;density;design;DNA;Doctor of Philosophy;Education;Educational process of instructing;Epidemiologic Methods;Epidemiology;Evaluation;Event;follow-up;Frequencies;Future;Genetic;genetic analysis;genetic epidemiology;Genetic Markers;Genetic study;Genetic Variation;Genome;Genomic DNA;genomic locus;Genomics;Genotype;Geography;Goals;Haplotypes;Human;improved;Individual;Infection;Infectious Disease Epidemiology;insight;Interdisciplinary Study;Intervention;Investigation;Investments;Knowledge;Leadership;Liver;Location;Malaria;malaria infection;marginalized community;Medical;Methods;microbial genomics;Molecular;neglect;novel marker;Parasitemia;Parasites;Participant;pathogen;Patients;Pattern;Physicians;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Polymerase Chain Reaction;Population;population health;pressure;Prevalence;prevent;Prospective cohort;Public Health;Recurrence;Relapse;Research;Resolution;Risk;Risk Factors;Sampling;Schools;Scientist;screening;Seasons;segregation;sex;Single Nucleotide Polymorphism;skills;Structure;Surveys;synergism;Tanzania;targeted sequencing;Time;tool;Training;Translational Research;transmission process;treatment guidelines;whole genome;Work

PROJECT_TITLE: Population genomics and relapse epidemiology of Plasmodium ovale in sub-Saharan Africa


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Communication along the brain’s sensorimotor axis appears critical for the integration of sensations and movements associated with skilled behavioral learning. Yet, the neural circuits that integrate motor, sensory, and goal-related signals to detect errors and guide sensorimotor learning in mammals remain unidentified. This project will uncover the function of these circuits and provide insight into how the brain drives behavioral adaptions in dynamic sensory environments.

PI_NAMEs: ZEMPOLICH, GRANT WILLIAM MEANY (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Address;Animals;Apical;Auditory;Auditory area;auditory feedback;Behavior;Behavior Control;Behavioral;behavioral outcome;Behavioral trial;Brain;Brain region;cell cortex;cell type;Communication;Corpus striatum structure;Coupled;Cues;Drops;Engineering;Environment;Esthesia;expectation;experience;extracellular;falls;Feedback;Fingers;Forelimb;Future;Goals;Hand;Hearing;Human;improved;in vivo;insight;Lead;learned behavior;Learning;Learning Skill;Location;Mammals;Monitor;Monkeys;Motor;motor control;motor learning;Movement;multi-electrode arrays;Mus;neural;neural circuit;Neurons;novel;optogenetics;Outcome;Performance;Play;Projections and Predictions;response;Role;Sensory;sensory cortex;Sensory Process;Signal Transduction;skills;sound;Speech;Students;Testing;Time;Training;Update;Work

PROJECT_TITLE: A cortical role for skilled, sound-guided behavior in mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Catheter-associated urinary tract infections (CAUTI) are the most common nosocomial infections, with the majority being polymicrobial in nature. Proteus mirabilis is one of the most common causes of CAUTIs and it is frequently found to be co-colonizing with Enterococcus faecalis, with patients colonized by both pathogens suffering a significant increase in disease severity and risk of developing secondary sequelae, such as bacteremia. Understanding how these two disease-enhancing pathogens interact, defining the important factors and their role in biofilm formation, persistence, and pathogenesis of polymicrobial CAUTI has the potential to drive novel therapeutic development and inform best medical intervention practices.

PI_NAMEs: HUNT, BENJAMIN CARTER (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Adhesions;Affect;Antibiotic Resistance;Architecture;Bacteremia;Bacteria;Biological Assay;Biomass;Bladder;care burden;catheter associated UTI;Catheters;Cells;clinical practice;clinically relevant;Communicable Diseases;cytotoxicity;Data;Development;Disease;Disease Progression;disorder risk;Enterococcus faecalis;Exhibits;fitness;Genome;Glass;Glycine;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;Health Care Costs;Hospital Costs;Human;Immune;improved;Individual;Indwelling Catheter;Infection;insight;Intervention;Investigation;Knowledge;Length of Stay;Life Style;Literature;Mediating;Medical;Microbial Biofilms;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;Nature;Nosocomial Infections;novel;novel therapeutics;pathogen;Pathogenesis;Patient risk;Patient-Focused Outcomes;Patients;Phenotype;Physiological;Play;polymicrobial biofilm;Prevalence;prevent;Proteins;Proteomics;Proteus mirabilis;Protocols documentation;Pseudomonas fluorescens;Research;Resolution;Role;Sepsis;Series;Severities;Severity of illness;Spatial Distribution;Surface;Techniques;Testing;therapeutic development;Toxin;Training;transposon sequencing;Treatment Efficacy;Treatment Failure;Urinary Catheterization;Urinary tract;Urinary tract infection;Uropathogen;Virulence;Virulence Factors;Visualization;Work

PROJECT_TITLE: Proteus mirabilis RTX proteins: Role in polymicrobial biofilm formation and pathogenesis of catheter associated urinary tract infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Injuries to the central nervous system are devastating to human health and the limited regenerative capacity of the central nervous system is a primary cause for the long-term disability caused by such injuries. In the short- term, this work will identify cellular and genetic programs that are required for regeneration in the central nervous system. In the long term, this work will contribute to our growing understanding about how cells in the central nervous system respond to injury and inform our future treatment strategies for improving regeneration and ultimately functional recovery.

PI_NAMEs: HULEGAARD, ALEXANDRIA LASSETTER (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Affect;Animals;Astrocytes;Autopsy;Axon;axon guidance;axon injury;axon regeneration;Behavior;Body System;Brain;Brain Diseases;Candidate Disease Gene;cell behavior;Cell Physiology;cell type;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Cicatrix;CRISPR screen;Cues;Data;Event;experimental study;frontier;Functional Regeneration;Future;gene conservation;Genes;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Goals;healing;Health;Heterogeneity;Homologous Gene;Hour;Human;Image;imaging approach;improved;in vivo;Induced Neurons;Injury;insight;knock-down;Knowledge;Label;Leucine-Rich Repeat;Lifelong disability;Literature;Long term disability;Mammals;Measures;Mediating;Modeling;Molecular;Molecular Analysis;Molecular Genetics;molecular marker;Molecular Profiling;Morphology;Natural regeneration;Neuronal Injury;Neurons;Pathway interactions;Physiological;Physiology;Play;Process;programs;receptor;Recovery;Recovery of Function;regeneration potential;Regenerative capacity;Reporting;response;response to injury;Role;Severities;Signal Induction;Signal Transduction;Site;Spinal Cord;Spinal cord injury;System;Testing;therapeutic target;tool;treatment strategy;Work;wound healing;Zebrafish

PROJECT_TITLE: Astrocyte dynamics in spinal cord injury and their impact on regeneration


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: This project seeks to characterize the novel regulatory perspectives of the CD73/A2AR adenosine signaling pathway, where the GSH/Gpx4 axis plays a key role in T cell differentiation and survival by regulating its effector vs. exhaustion phenotype and metabolic commitment that should significantly forward the field of ACT for rapid translational implications.

PI_NAMEs: CUI, WEIGUO ;ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;Adenosine;Adoptive Cell Transfers;Adoptive Transfer;ADORA2A gene;Advanced Malignant Neoplasm;Anabolism;Antitumor Response;Apoptosis;Bioenergetics;Biological Markers;Biomedical Engineering;Breast Melanoma;cancer immunotherapy;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Survival;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Consumption;cytotoxic;Disseminated Malignant Neoplasm;Ectopic Expression;effector T cell;engineered T cells;Enzymes;exhaust;exhaustion;Future;Generations;Genetic;Glutamine;Glutathione;Glutathione Disulfide;glutathione peroxidase;Glycolysis;Grant;Human;Impairment;improved;in vivo;inhibitor;Intervention;Iron;Leucocytic infiltrate;Lipid Peroxidation;lipid peroxidation inhibitor;Malignant Breast Neoplasm;Mediating;Melanoma;Memory;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial fitness;Molecular;mouse model;MSLN gene;Mus;Neoplasm Metastasis;neoplastic cell;novel;Nucleic Acid Regulatory Sequences;Oxidative Stress;Pathway interactions;Patients;pharmacologic;Phenotype;Play;prevent;Proliferating;receptor;Receptor Cell;Receptor Inhibition;Receptor Signaling;Reporting;Respiration;response;Role;Safety;Signal Pathway;Signal Transduction;stemness;T cell differentiation;T cell response;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Tissues;Toxic effect;transcription factor;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression

PROJECT_TITLE: Sustaining antitumor effector CD8+ T cells for cancer therapy

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The University of Minnesota's R25 Short-Term Training Research Education Program has demonstrated remarkable success in advancing diversity in the biomedical workforce, supporting 294 talented undergraduate individuals from diverse backgrounds over 15 years. The program seeks continued funding to sustain participant diversity, strengthen the Pre-Medical Scientist Training Program (Pre-MSTP) module, and develop an innovative research training module (Bio-LEAP) for community college transfer students, fostering excellence and inclusivity in the biomedical research community.

PI_NAMEs: CAMPBELL, COLIN R (contact);NGUYEN, DANG HAI

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Achievement;Address;Admission activity;Arts;Bachelor's Degree;Biological Sciences;Biomedical Research;Cancer Education Grant Program;career;catalyst;Clinical;clinical practice;college;Communication;Communities;community college;Dedications;Degree program;Doctor of Philosophy;Education;Education Projects;education research;Educational workshop;Effectiveness;efficacy validation;Elements;Eligibility Determination;empowerment;Enrollment;Ensure;Environment;Event;experience;Faculty;faculty mentor;forging;Fostering;frontier;Funding;Future;Generations;Goals;graduate school;implicit bias;Individual;innovation;interest;learning community;matriculation;Medical;medical schools;Mentors;Mentorship;Minnesota;Mission;National Heart, Lung, and Blood Institute;next generation;Outcome;Participant;peer;peer coaching;Physicians;programs;Qualifying;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Science Enrichment;Scientist;skills;social;Students;success;summer research;symposium;Syndrome;Talents;tool;Training;Training Activity;Training Programs;transfer student;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Vision

PROJECT_TITLE: Summer Research at the University of Minnesota Medical School

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (J1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Normal brain vascular development during pregnancy is crucial for healthy brain function after birth, and disruptions to this development can result in lifelong health complications or death. We aim to uncover how a crucial component of the brain vasculature, the blood-brain barrier (BBB), develops during gestation and how this barrier regulates immune cell entry into the brain. This work will advance prenatal and infant care by informing the development of targeted therapies for brain-related disorders with prenatal or early onset.

PI_NAMEs: WEDDERBURN-PUGH, KAYLEE  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Adult;Anatomy;Birth;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain Diseases;brain health;Brain region;cell motility;cell type;Cells;cellular engineering;cerebrovascular;Cerebrovascular system;Cessation of life;Characteristics;Complex;Data;Data Set;design;Development;Disease;early onset;Endothelium;Engineering;Fetal Liver;Flow Cytometry;Fluorescence-Activated Cell Sorting;Functional disorder;Genetic Transcription;Goals;Health;Heterogeneity;Immune;Immunofluorescence Immunologic;In Situ Hybridization;in utero;In Vitro;Infant Care;Injections;innovation;insight;Knowledge;Liver;Maps;Mediating;Microglia;migration;Modeling;Molecular;Mus;novel strategies;Outcome;Outcomes Research;Peripheral;Permeability;permissiveness;Phenotype;Play;Population;Pregnancy;prenatal;progenitor;Property;Publishing;Regional Anatomy;RNA;Role;Route;Signal Transduction;single-cell RNA sequencing;Site;spatiotemporal;Stains;stem cell differentiation;Subcellular Anatomy;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;therapeutic target;therapy design;therapy development;Time;timeline;trafficking;Vascular Permeabilities;Venous;Work;Yolk Sac

PROJECT_TITLE: Investigating the role of the blood-brain barrier in trafficking prenatal liver-derived immune cells into the brain


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The goal of this proposal is to test whether particular features of the voice are indicators of the slowing and agitated movements that are characteristic of depression. The project will also test whether these abnormalities in movement (a) are only present in individuals with current depression or are also present in those whose depression has remitted, (b) change over time as currently depressed individuals recover, or as remitted individuals relapse, and (c) can be measured outside of the lab, more naturalistically. Taken together, understanding these movement abnormalities may lead to path-breaking early detection strategies, that help to predict the course of depression, and inform treatment strategies.

PI_NAMEs: GOLDRICK, MATTHEW A;MITTAL, VIJAY A;SHANKMAN, STEWART AARON (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acoustics;actigraphy;Acute;Address;Age;Agitation;Behavior;Behavioral;Cellular Phone;Characteristics;Cicatrix;Clinical;clinically significant;Computing Methodologies;Contingent Negative Variation;Data;Depressed mood;depressive symptoms;design;Disease remission;disorder control;Dyskinetic syndrome;Early Diagnosis;Electroencephalography;Event-Related Potentials;follow-up;Goals;improved;improved outcome;in vivo;Individual;Individual Differences;Laboratories;Language;Lateral;longitudinal design;Longitudinal Studies;Major Depressive Disorder;Measurable;Measures;Mediating;Mental Depression;Monitor;Motor;motor behavior;motor control;motor impairment;motor symptom;Movement;neural circuit;novel;Outcome;Participant;Pathogenicity;Patient Self-Report;Pattern;Predisposition;Process;prospective;Psychomotor Performance;Psychopathology;Public Health;Reaction Time;recruit;Relapse;relapse prediction;Reporting;Research;Risk;Role;Severities;Signal Transduction;smartphone based assessment;social;Speech;Standardization;symptomatology;Symptoms;Testing;Time;Training;treatment response;treatment strategy;Voice;Work

PROJECT_TITLE: Motoric features of the voice as indicators of psychomotor agitation and retardation in current and remitted MDD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (02)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal of this proposal is to better understand the structural mechanisms of intercellular channels known as gap junctions that are linked to cataracts and various retinopathies. We will apply cutting-edge technologies in single particle Cryo-EM to define unique structural features of lens and retina gap junctions by the latest biomolecular tools in structural biology. These insights can be used to guide the rational design of next- generation pharmacological tools in vision.

PI_NAMEs: SOUZA, SAMSON  (contact)

PROJECT_TERMS: Adult;Affinity;age related;Anti-malarials;Arrhythmia;Binding;Binding Sites;Biological Assay;Biology;Biophysics;Blindness;Cataract;Cells;Collaborations;combat;Communication;comparative;Complex;connexin 36;Connexin 43;Connexins;Cryoelectron Microscopy;deafness;design;Development;Diabetic Retinopathy;Disease;DNA Sequence Alteration;drug development;drug-like compound;Exhibits;Fab Immunoglobulins;FDA approved;Fluorescence;Future;gap junction channel;Gap Junctions;GJB2 gene;Glaucoma;Glean;Goals;Health;Homeostasis;In Vitro;inhibitor;innovation;insight;Ion Channel;Ions;Laboratories;lens;lens gap junction;lens intrinsic protein MP 70;Link;Malignant Neoplasms;Measures;Mefloquine;Mentors;Modeling;Mutation;Nervous System Disorder;next generation;novel therapeutics;particle;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Protein Isoforms;rational design;Resolution;Retina;Retinal Diseases;Role;Signal Transduction;skin disorder;small molecule;small molecule inhibitor;Specificity;Stress;Stroke;structural biology;Structure;Technology;therapeutic target;Tissues;tool;Training;United States National Institutes of Health;Vision;Visual;Visual System;Work

PROJECT_TITLE: Structural basis of selective inhibition toward gap junction channels involved in vision.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Estrogen;Neurosciences;Substance Misuse;Tobacco;Women's Health Research

PHR: Project Narrative: Sex differences in nicotine effects combined with blunted responses to treatment approaches combine to lead to worse treatment outcomes for nicotine addiction in women. Nicotine acts through hijacking endogenous acetylcholine signaling, which ultimately leads to the increases in dopamine release that drive nicotine reinforcement. This grant focuses on outlining how ovarian hormones contribute to sex differences in dopamine release regulation by acetylcholine in female subjects, and will provide a better understanding for pharmacotherapeutic approaches for nicotine treatment in women.

PI_NAMEs: HOLMGREN, ELEANOR BAILEY (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acetylcholine;Action Potentials;Acute;addiction;Adult;Affect;Agonist;Animals;antagonist;Axon;Bathing;Behavior;Biosensor;Brain;career development;cell type;cholinergic;Cholinergic Receptors;Corpus striatum structure;Cues;Data;Distal;Dopamine;dopamine system;dopaminergic neuron;effective therapy;Electrophysiology (science);ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Fellowship;Female;Genetic;genetic approach;Goals;GPER gene;Grant;Health;hormone regulation;Image;in vivo;Individual;Institution;Interneurons;Intervention;Knock-out;Knowledge;Lesion;Maintenance;male;Mediating;Motivation;Mus;neural;Neurons;Neurosciences;Nicotine;nicotine cue;Nicotine Dependence;nicotine replacement;nicotine self-administration;nicotine treatment;nicotine use;nicotinic receptor beta2;Nicotinic Receptors;Nucleus Accumbens;optical imaging;Optics;optogenetics;Ovarian hormone;Ovariectomy;Pathway interactions;Pharmacodynamics;pharmacologic;Play;Positioning Attribute;Presynaptic Terminals;Property;Psychological reinforcement;Public Health;receptor;Regulation;Reporting;response;Role;sensor;Sex Differences;Signal Transduction;Site;Slice;Smoking;System;tenure track;Therapeutic Intervention;tool;Training;Transgenic Organisms;Treatment Efficacy;Treatment outcome;treatment response;Vulnerable Populations;Woman;women subjects;women's treatment;Work

PROJECT_TITLE: The Role of Ovarian Hormones in Regulating Dopamine Acetylcholine Interactions in the Nucleus Accumbens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Disease modifying drugs have greatly improved the treatment of autoimmune arthritis, but patients can experience recurrent and uncontrolled intervals of disease flares. This project aims to validate an agent for modulating inflammatory immune cells associated with flares and thereby potentially sparing joints from further damage. If successful, the approach has the potential to pave the way for a treatment that achieves durable arthritis flare control.

PI_NAMEs: JOHNSON, WADE TRUMAN (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adjuvant;Adrenal Cortex Hormones;aggrecan;Animal Model;Antigen-Presenting Cells;Arthritis;arthropathies;Autoantigens;Autoimmune;autoimmune arthritis;Autoimmune Diseases;Autoimmune Responses;autoreactivity;biceps brachii muscle;Biocompatible Materials;Biodistribution;bone erosion;C Type Lectin Receptors;Calcitriol;career;Cartilage;Cell Maturation;Cells;Chronic;Clinic;Clinical;Collagen;Collagen Arthritis;Competence;Complement;Complex;copolymer;Cysteine;cytokine;Dendritic Cells;Development;Disease;Disease-Modifying Second-Line Drugs;disorder control;Dose;draining lymph node;Drug Delivery Systems;Drug Kinetics;effectiveness evaluation;Encapsulated;ethylene glycol;experience;experimental study;Fellowship;Flare;Frequencies;Glycolates;Haplotypes;Hormones;Immune;immune activation;immune modulating agents;Immune response;immunoengineering;Immunophenotyping;immunoregulation;Immunosuppression;improved;in vivo;indexing;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory modulation;Injections;Intramuscular;joint inflammation;joint injury;Joints;Knowledge;Lectin Receptors;Liquid substance;lymph nodes;lymphoid organ;Maleimides;Measures;Mediating;Methotrexate;Mission;Modeling;Modification;mouse model;Mus;N-terminal;nano;nanomaterials;nanometer;nanoparticle;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Non-Steroidal Anti-Inflammatory Agents;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Pattern recognition receptor;Peptides;Pharmaceutical Preparations;Play;potential biomarker;Precipitation;prevent;Process;protective effect;Proteoglycan;Recurrence;Recurrent disease;Research;response;Rheumatism;Rheumatoid Arthritis;Risk Reduction;Role;safety assessment;skills;small molecule;standard of care;Steroids;Structure;Systemic disease;Testing;Tissues;Toll-like receptors;Toxic effect;Training Programs;transcriptomics;treatment group;Validation

PROJECT_TITLE: Immunoregulatory biomaterials for modulating arthritis flares

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE Over the past decade, the number of large multi-center neuroimaging studies has skyrocketed due to growing investments by federal governments and private entities interested in brain development, aging, and pathology. This has led to the accumulation of vast amounts of magnetic resonance imaging (MRI) data acquired using various study designs, but the statistical methodology necessary for harmonizing these data for integrated analyses is currently lacking. In this project, we propose to develop, implement, and apply next-generation imaging harmonization methods and harmonization in the context of diagnostic and prognostic biomarkers, which has become a central issue for precision medicine.

PI_NAMEs: SHINOHARA, RUSSELL TAKESHI (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Adolescent;Adopted;Aging;Alzheimer's Disease;Atrophic;Biological;Brain;cognitive development;Cohort Studies;combat;Communities;Complex;complex data;Computer software;Data;data harmonization;data integration;Databases;deep learning;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Procedure;Disease;Disease Progression;Dwarfism;experimental study;Explosion;Family;Federal Government;flexibility;Future;Genomics;gray matter;healthy aging;Hybrids;Image;image processing;image reconstruction;Imaging Device;imaging science;improved;indexing;Individual;interest;Investments;Knowledge;life span;Machine Learning;Magnetic Resonance Imaging;Measures;Methodology;Methods;mild cognitive impairment;Modernization;neuroimaging;Neurosciences;next generation;novel;Outcome;Pathology;Performance;Phenotype;Physics;precision medicine;predictive modeling;preservation;Privatization;prognostic;Prognostic Marker;prognostic model;Protocols documentation;Psychopathology;Reproducibility;Research Design;Sampling;Scanning;Science;Sex Differences;Site;Statistical Methods;Statistical Models;statistics;Structure;success;Technical Degree;tool;translational scientist;Translations;Uncertainty;user friendly software;Work

PROJECT_TITLE: Harmonization of Multi-Site Neuroimaging Data from Complex Study Designs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  The goal of this project is to develop and test a framework describing the multimodal affective environment that supports language development in early childhood. Using computational analyses of infants’ at-home environments in the first years of life as well as a series of tightly-controlled experiments, we ask (1) how affective contexts shape word learning and (2) how children with depressed caregivers adapt their learning strategies to the decreased affective information in their environments. Understanding how children with depressed caregivers use affective information to learn new words may inform tailored efforts to promote equity in educational outcomes.

PI_NAMEs: NENCHEVA, MIRA L. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Affect;Affective;Age;Arousal;Attention;Birth;career;caregiver depression;Caregivers;Child;Child Development;Child Language;Clinical;Clinical Research;clinically significant;Code;Cognitive;cohort;Communication;Complex;Computer Analysis;Computer Vision Systems;Computing Methodologies;contextual factors;Cues;Data Set;Depressed mood;depressive symptoms;Development;Dimensions;early childhood;Education;Emotional;Emotions;Environment;Equity;Event;experience;Experimental Designs;experimental study;Face;Family;Goals;Hearing;Home;Home environment;Household;Infant;insight;Intervention;Investigation;Knowledge;laboratory experiment;Language;Language Development;language outcome;large datasets;Learning;learning strategy;Life;Link;Longitudinal Studies;Machine Learning;member;Memory;Mental Depression;Mentorship;Methods;Modality;Modeling;Mood Disorders;Mothers;multimodality;Natural Language Processing;novel;Outcome;Participant;Personal Satisfaction;Poverty;professor;programs;promote resilience;Public Health;Readiness;Research;Resources;Role;Schools;Science;Semantics;Series;Severities;Shapes;Social Environment;Social Interaction;Source;Speech;Structure;System;Testing;theories;Time;tool;Training;translational goal;Universities;Variant;verbal;word learning;Work

PROJECT_TITLE: Characterizing the role of affective information in early word learning using observational and experimental designs

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative As of 2021, 8 million people in the US are suffering from post-traumatic stress disorder (PTSD), a psychiatric disorder causing behavioral and functional impairment, and we report an increased incidence of PTSD among individuals with chronic traumatic encephalopathy (CTE). Yet, little is known about the pathological underpinnings of PTSD or its interaction with Alzheimer’s Disease related dementias. This proposal compares neuroinflammatory pathology of PTSD subjects with or without CTE to improve our understanding of disease development, which follows the NIH mission to seek fundamental knowledge about the brain to reduce burden of neurological disease.

PI_NAMEs: CALDERAZZO, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Affect;Alzheimer's disease related dementia;Anxiety;Athletic;Autoimmune Diseases;Autopsy;behavioral impairment;Biological Markers;Blood;Blood Vessels;Boston;Brain;Cell Count;Cells;chronic traumatic encephalopathy;Clinical;Clinical Data;clinical diagnosis;clinical investigation;clinically relevant;Collection;comorbidity;comparison control;Confocal Microscopy;cytokine;Data;Databases;density;Development;Diagnosis;Disease;experience;Exposure to;Fluorescent in Situ Hybridization;Foundations;frontal lobe;Functional disorder;Functional impairment;Gene Expression;General Population;Genes;Genomics;Goals;head impact;Histologic;Human;Immune;Immunofluorescence Immunologic;Impaired cognition;improved;In Situ Hybridization;Incidence;Individual;Inflammatory;Knowledge;Label;Literature;Magnetic Resonance Imaging;Measures;Mediating;Memory impairment;Memory Loss;Mental disorders;Microglia;Military Personnel;Mission;Modeling;Nerve Degeneration;Nervous System Disorder;neuroimaging;neuroinflammation;Neurologic;neuropathology;Pathologic;Pathology;Patients;Pattern;peripheral blood;Persons;Phagocytes;Phagocytosis;Phenotype;Post-Traumatic Stress Disorders;recruit;Reporting;Resolution;Risk;Rodent;Rodent Model;Role;Signal Transduction;single nucleus RNA-sequencing;spatial relationship;suicidal risk;Symptoms;Synapses;T cell infiltration;T-Cell Activation;T-cell inflamed;T-Lymphocyte;tau aggregation;tau Proteins;tau-1;Tauopathies;Techniques;therapeutic target;Tissues;Traumatic Brain Injury;traumatic event;United States Department of Veterans Affairs;United States National Institutes of Health;Universities

PROJECT_TITLE: Neuroinflammatory Alterations in Post-Traumatic Stress Disorder and Chronic Traumatic Encephalopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE While microbiota alterations and selected metabolites have been implicated in the regulation of cardiovascular diseases (CVD), our current knowledge regarding the mechanisms that regulate host-microbiota interactions, their potential alteration due to intestinal inflammation, and their specific mechanistic impact on immune cell activation in CVD is quite limited. Here we propose to investigate previously underappreciated in the field of CVD role of IL17RC cytokine signaling as key regulator of intestinal epithelium metabolism, microbiota and immune cell function in atherosclerosis and identify its contribution to neuroinflammation in the aorta. The results from this innovative study will establish novel IL17RC-dependent mechanisms of CVD and will aid future preventive and therapeutic approaches.

PI_NAMEs: KOLTSOVA, EKATERINA  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Ablation;Acceleration;Address;Adrenergic Agents;Affect;Antibiotics;Aorta;Aortitis;Arteries;atheroprotective;Atherosclerosis;Automobile Driving;Bacterial Translocation;Brain;Cardiovascular Diseases;Cause of Death;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Chronic;chronic inflammatory disease;Circulation;Coupled;cytokine;Cytokine Signaling;Data;Denervation;design;Development;dietary;Disease;Distant;Epithelial Cells;experimental study;Future;gain of function;Gene Expression Profile;Growth;gut inflammation;gut microbiota;host microbiota;Human;IL17 gene;Image;Immune;immune activation;Immunity;Immunologics;in vivo;Inflammation;Inflammation Mediators;Inflammatory;innovation;intestinal barrier;intestinal epithelium;Intestines;Knowledge;Link;lipidomics;loss of function;Malignant Neoplasms;Mediating;Metabolic Pathway;Metabolism;metabolomics;microbial;microbiota;microbiota composition;Molecular Biology;mouse model;Mus;Myocardial Infarction;neuroinflammation;neuronal growth;Neurons;novel;Organoids;Outcome;Oxygen;Pathogenesis;Pathway interactions;Play;Predisposing Factor;Preventive;receptor;Regulation;Reporting;Role;Scheme;Signal Transduction;Skin;Stroke;Testing;Therapeutic;transcriptomics;Up-Regulation

PROJECT_TITLE: IL17RC signaling as a regulator of host- microbiota interactions and aortic neuroinflammation in atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (02)]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Neurological injuries, such as stroke or motor neuron disease, can lead to loss of speech, significantly limiting communication abilities and negatively impacting quality of life; however, speech neuroprostheses offer hope in restoring communication by directly decoding cortical activity into intended speech. Despite over half of the world's population being bilingual and each language contributing unique dimensions to bilinguals' personality and worldview, previous decoding studies have predominantly focused on monolingual speech. In light of this, the proposed project will investigate the precise cortical activity patterns that underlie bilingual speech and use these findings to develop a bilingual speech neuroprosthesis capable of decoding cortical activity into language- specific phrases.

PI_NAMEs: SILVA, ALEXANDER BUDUGUR (contact)

PROJECT_TERMS: Address;Adopted;Algorithms;Amyotrophic Lateral Sclerosis;Anatomy;Articulation;Articulators;bilingualism;Bypass;Characteristics;Classification;Communication;Consensus;cortex mapping;Data;Data Set;Dedications;deep learning;density;Development;Dimensions;Electrocorticogram;Electrodes;Hour;Impairment;Inferior frontal gyrus;Jaw;Language;Larynx;Learning;lexical;Light;Lip structure;Literature;Machine Learning;Methodology;millisecond;Modeling;motor disorder;Motor Neuron Disease;Motor Pathways;Movement;Multilingualism;natural language;Nervous System Disorder;Nervous System Trauma;neural;Neurologic Symptoms;neuroprosthesis;neurosurgery;Output;Paralysed;Parietal Lobe;Participant;Patients;Pattern;Performance;Personality;Persons;phrases;Population;Production;Quality of life;Reporting;Research;Resolution;Running;Signal Transduction;Site;Social Environment;Spanish;Spanish/English;spatiotemporal;Speech;Statistical Models;Stroke;System;Techniques;Technology;Telephone;Testing;Time;Tongue;Training;training data;transfer learning;Work

PROJECT_TITLE: Developing a bilingual speech neuroprosthesis


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE  Social drinking contexts are frequently associated with negative consequences, including binge drinking and an increased risk of developing Alcohol Use Disorder (AUD). The proposed study seeks to improve the understanding of neurocognitive mechanisms underlying alcohol reinforcement in social contexts. Understanding these mechanisms has important theoretical and clinical implications, including advancing theoretical models of AUD vulnerabilities and improving treatment and prevention programs by identifying “high-risk” settings associated with heightened alcohol reinforcement.

PI_NAMEs: HAN, JIAXU  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: addiction;Address;Affective;Alcohol consumption;alcohol effect;alcohol involvement;alcohol myopia;alcohol reinforcement;alcohol reward;alcohol use disorder;Alcohols;Area;Attention;Automobile Driving;Award;Bacterial Artificial Chromosomes;Beverages;binge drinking;biopsychosocial;Brain;career;Clinical;Cognitive;Consumption;Cues;Data;Development;dosage;Dose;drinking;Electroencephalography;Electrophysiology (science);Emotional;emotional experience;Etiology;experience;Familiarity;Feeling;Friends;Goals;high risk;improved;in vivo;indexing;Individual;Influentials;intervention program;joint attention;Knowledge;Laboratories;Link;Measurement;Measures;Mentorship;Methodology;Methods;Modernization;Music;National Institute on Alcohol Abuse and Alcoholism;neural;neural correlate;Neurocognitive;neuroimaging;non-alcoholic;novel;Occupations;parent project;Parents;Participant;Patient Self-Report;Persons;pilot trial;positive mood;pre-doctoral;Prevention program;Psychophysiology;Randomized;Reporting;Research;Research Personnel;response;Rewards;Risk;Science;Scientific Advances and Accomplishments;Scientist;Signal Transduction;skills;social;social anxiety;social attachment;social cohesion;Social Environment;Stimulus;Strategic Planning;Technology;Testing;Thalamencephalon;Theoretical model;theories;Time;tool;Training;treatment program

PROJECT_TITLE: Examining the Neural Correlates of Alcohol Reward in Social Context: A Hyperscanning EEG Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative One of the main functions of the kidney is to match water output (urine volume) to water intake (drinking volume). I discovered that a receptor, known as GPR39, is found in specialized cells in the kidney that control how dilute or concentrated the urine is. In this proposal I will uncover how GPR39 influences the function of these cells (Aim 1), and how GPR39 contributes to our ability to maintain water balance (Aim 2).

PI_NAMEs: KUI, MACKENZIE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;Agonist;Agreement;Angiotensin II Receptor;Animals;aquaporin-2;AVPR2 gene;beta-arrestin;Biological Assay;bone;Brain region;Cell Physiology;Cells;Creatinine;Cyclic AMP;Data;Dose;drinking;drinking behavior;Duct (organ) structure;Ductal Epithelial Cell;Electron Microscopy;Endocytosis Induction;Equilibrium;Evaluation;experimental study;Functional disorder;G-Protein-Coupled Receptors;Gastrointestinal tract structure;GPR39 gene;GTP-Binding Protein alpha Subunits, Gs;Heart;Hematocrit procedure;Hemoglobin;Homeostasis;Hydration status;immunocytochemistry;Immunofluorescence Immunologic;In Vitro;insight;Intervention;Investigation;Kidney;kidney cell;kidney cortex;kidney medulla;Knock-out;knockout animal;Knockout Mice;Ligands;mammalian genome;Measures;Mediating;Molecular Analysis;Monitor;Mus;Neurons;novel;Osmolalities;Output;Pancreas;Peripheral;Permeability;pharmacologic;Phosphorylation;Physiological;Physiological Processes;Physiology;Plasma;Play;prevent;Proteins;Publishing;receptor;Receptor Activation;Recovery;Regulation;Renal function;Renal Tissue;Reporting;Research Personnel;response;Role;seven-transmembrane G-protein-coupled receptor;Signal Transduction;Skin;Sodium;Stress;Testing;Tight Junctions;Time;Tissues;tool;trafficking;Transmembrane Domain;Universities;Urea;urinary;Urine;Vasopressin Receptor;Vasopressins;Vertebrates;Water;Water consumption;Western Blotting;Wild Type Mouse;Zinc

PROJECT_TITLE: Uncovering the Role of GPR39 in the kidney

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Prostate Cancer;Rehabilitation;Social Determinants of Health;Urologic Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE A healthy diet has the potential to improve health outcomes and quality of life for prostate cancer (PCa) survivors and their partners. We will investigate how PCa survivors and their partners adopt and maintain a healthy diet within the context of their dyadic relationship and neighborhood conditions. This award will accelerate my development as an independent behavioral and nurse scientist dedicated to identifying equitable approaches and couple-focused strategies to support cancer survivors and partners to adopt and maintain healthy lifestyle behaviors.

PI_NAMEs: XU, JINGLE  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acceleration;Address;Adherence;Adopted;Area;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Buffers;built environment;cancer diagnosis;cancer education;Cancer Patient;Cancer Survivor;Cancer Survivorship;career development;Cause of Death;Chronic Disease;Collaborations;Colorectal Cancer;commune;Communication;comorbidity;comparison intervention;Couples;Data;Data Analyses;Dedications;deprivation;Development;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;Disparity;Distress;Eating;Environment;Equation;Equity;experience;Family;feasibility testing;Food;Food Access;good diet;Health;Health behavior;health belief;health equity;Health Promotion;healthy lifestyle;Heart Diseases;Hypertension;improved;indexing;Interactive Communication;Intervention;Interview;Knowledge;Lead;lens;Life;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Mediation;Medical center;men;Methods;Modeling;mortality;neighborhood disadvantage;Neighborhoods;neoplasm resource;North Carolina;Nurses;Obesity;Outcome;Physical activity;Population;post-doctoral training;Prevention;Process;prostate cancer survivors;Psyche structure;Quality of life;recruit;Research;Research Personnel;Resources;Scientist;Screening for cancer;secondary analysis;Social Environment;social health determinants;Specific qualifier value;Spouses;Strategic Planning;Stroke;survival outcome;Survivors;survivorship;Testing;therapy development;Time;Training;United States;Universities;Variant

PROJECT_TITLE: The processes through which prostate cancer survivors and their partners adopt and maintain a healthy diet during prostate cancer survivorship

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Treg cells are lymphocytes that suppress the activation of other immune cells and protect against autoimmune disease. There is little understanding of the translational regulation of Tregs. Studies are described to fully characterize how specialized mRNA translation regulates the Treg cell types.

PI_NAMEs: SCHNEIDER, ROBERT JAY (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Autoimmune Diseases;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Lineage;cell type;Cells;Complex;conditional knockout;Dependence;Development;Event;Foundations;FOXP3 gene;Generations;Genetic Transcription;genome-wide;Homeostasis;Immune;Inflammatory;interest;Knockout Mice;Lymphocyte;Lymphocyte Suppression;Maintenance;Mediating;Mediator;Messenger RNA;Modification;Molecular;mRNA Translation;Mus;novel;Phenotype;protein expression;Regulatory T-Lymphocyte;ribosome profiling;Role;T cell regulation;T-Cell Development;T-Lymphocyte;transcriptome sequencing;Translating;translation factor;Translation Initiation;Translational Regulation;Translations;Work

PROJECT_TITLE: Translational Regulation of T Regulatory Cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The rapid evolution of seasonal influenza A viruses results in new variants that require our vaccines to be updated each year. There is currently a lack of understanding of how these variants arise amongst individual hosts to then go onto circulate globally. This research aims to address this gap with the goal of improving our ability to anticipate the evolution of influenza A viruses when designing seasonal vaccines.

PI_NAMEs: RAGHUNATHAN, VEDHIKA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Address;Animals;Antibodies;Bar Codes;Biological;Cavia;Circulation;Cloning;Data;design;digital;Economics;Environment;Evolution;experimental study;fitness;Frequencies;Gene Frequency;Genes;Genetic;Genetic Variation;Glycoproteins;Goals;Health;Hemagglutinin;Immune;Immunity;Immunize;improved;Inactivated Vaccines;Individual;Infection;Influenza A virus;Influenza A Virus, H3N2 Subtype;Knowledge;Laboratories;Measures;Minor;Monitor;Monoclonal Antibody F19;mutant;Mutation;Nasal Lavage Fluid;next generation sequencing;novel;Pattern;Play;Population;pressure;Prevalence;Process;rare variant;Recurrence;Research;response;reverse genetics;Role;Sampling;seasonal influenza;Seasons;Shapes;Single Nucleotide Polymorphism;Site;System;Testing;Texas;Time;transmission process;United States;Update;Vaccinated;Vaccination;vaccination outcome;Vaccine Design;vaccine evaluation;Vaccines;Variant;Viral;Virus

PROJECT_TITLE: Within and between host dynamics in influenza A virus antigenic evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Obesity is associated with worse morbidity and mortality of pulmonary viral infections like SARS-CoV-2, however the effects of obesity on intestinal viral infections, specifically norovirus, remains poorly understood. My new preliminary data reveal that human and murine obesity are associated with protection from norovirus infection in association with enhanced norovirus-specific antibody production. In this proposal, I will determine how the adaptive immune response (Aim 1) and interferon signaling (Aim 2) mediate protection against norovirus infection in high fat diet-induced obese mice.

PI_NAMEs: WRIGHT, JASMINE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immune response;adaptive immunity;Address;Adoptive Transfer;Adult;Affect;Antibodies;Antibody Formation;B-Lymphocytes;Body mass index;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical Data;Colon;comparison control;Data;detection limit;Diagnosis;Diet;diet-induced obesity;enteric virus infection;Exhibits;Feces;feeding;Flow Cytometry;Gastroenteritis;Gastrointestinal tract structure;Genes;global health;Heart Diseases;High Fat Diet;Host Defense Mechanism;Human;Immune;Immune response;Immune system;immune system function;Immunity;Immunoglobulin A;Immunoglobulin G;Impairment;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;innovation;insight;Interferon Receptor;Interferon Type II;Interferons;intestinal epithelium;Intestines;Kidney Diseases;Lamina Propria;Lead;Lung;Measures;Mediating;Metabolic Diseases;Morbid Obesity;Morbidity - disease rate;mortality;mouse model;MS4A1 gene;Mus;Non-Insulin-Dependent Diabetes Mellitus;Norovirus;novel;Obese Mice;obese patients;Obesity;pathogen;Pathogenesis;Pathway interactions;Population;Predisposition;Production;protective factors;receptor expression;Regulation;response;Risk Factors;Role;SARS-CoV-2 infection;secondary lymphoid organ;Serum;Severity of illness;Shapes;Signal Transduction;Symptoms;T cell response;Testing;Thinness;Time;translational potential;Tropism;Vaccines;Viral;Viral Gastroenteritis;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Immunometabolic regulation of enteric viral infection


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Narrative Neurodegenerative diseases of all types – and especially Alzheimer’s disease and related dementias – represent an ever-increasing public health crisis as our society ages without effective therapeutic interventions. Recent advances in both biological and genetic studies implicate changes in cellular compartments known as endosomes and lysosomes in the onset and/or progression of these diseases. The goal of the Lysosomes and Endocytosis conference and seminar is to assemble a multidisciplinary group of researchers to discuss and debate the molecular mechanisms responsible for formation and function of these compartments with particular focus on their contribution to neurodegenerative disease.

PI_NAMEs: HANSON, PHYLLIS I (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Address;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Area;Biological;biological systems;Biology;career;career development;Cells;Cellular biology;Clinic;Collaborations;Communities;Complement;Complex;Data;Defect;Dementia;design;Development;Discipline;Disease;Disease Progression;disorder control;Employment Opportunities;empowerment;Endocytosis;Endosomes;Environment;Etiology;exosome;Faculty;Fostering;Future;Genes;Genetic;Genetic study;Goals;graduate student;Health;Human;improved;Industry;Infection;insight;interest;International;Knowledge;Learning;Lysosomes;meetings;Mentorship;Metabolic;Michigan;microbial;Modernization;Molecular;multidisciplinary;National Institute on Aging;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologist;Neurons;Neurosciences;older adult;Organelles;Participant;Pathogenesis;Pathologic;Pathway interactions;Physicians;Physiological;Physiology;Postdoctoral Fellow;posters;programs;Public Health;public health intervention;Research;Research Personnel;Research Support;Scientist;Site;Social Interaction;Societies;stressor;Structural Biologist;symposium;System;Therapeutic;Therapeutic Intervention;therapeutically effective;training opportunity;Translating;Underrepresented Populations;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: 2024 Lysosomes and Endocytosis Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]