PI_NAMEs: ARTEEL, GAVIN E (contact)

PROJECT_TERMS: Applied Research;Area;Award;Awareness;Basic Science;Categories;Clinic;Clinical;clinically relevant;Collaborations;Data;Dedications;Development;Disease;Eligibility Determination;Environment;Evaluation;Exclusion;Extramural Activities;Faculty;falls;Foundations;Functional disorder;fundamental research;Funding;Goals;Grant;Health;health science research;Howard Temin Award;improved;Incentives;innovation;Institution;Instruction;instructor;Interdisciplinary Study;K-Series Research Career Programs;Leadership;Liver;Liver diseases;liver function;Longevity;Mentors;Methodology;Mission;multidisciplinary;Organization and Administration;Outcome;Peer Review;Physicians;Pilot Projects;Positioning Attribute;professor;programs;Qualifying;recruit;Research;Research Assistant;Research Personnel;Resources;Science;Scientist;Secure;Solid;success;synergism;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Feasibility Grants


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: NEJAK-BOWEN, KARI N (contact)

PROJECT_TERMS: Academic skills;Address;Advanced Development;Area;base;Basic Science;Boston;career;career development;Clinic;Clinical;clinical care;Clinical Research;Collaborations;Communities;Dedications;Disease;education planning;Educational workshop;Exhibits;Extramural Activities;Faculty;Fostering;Goals;graduate student;Health;Illinois;improved;Information Dissemination;Injury;innovation;Institution;Instruction;interdisciplinary approach;Interest Group;Knowledge;Liver;Medical center;Medicine;member;Mission;Operative Surgical Procedures;Organization and Administration;Pathology;Pediatric Hospitals;Physicians;Postdoctoral Fellow;Program Development;programs;Relationship-Building;repaired;Research;Research Personnel;Resources;Science;Scientist;Series;skill acquisition;success;Training Activity;Translations;Universities;virtual;Visit;Work

PROJECT_TITLE: Enrichment Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J4)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Nutrition;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: SOLNA

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: KAROLINSKA INSTITUTE

PHR: PROJECT NARRATIVE / RELEVANCE The Eating Disorders Genetics Initiative 2 (EDGI2) unites existing and exceptionally productive and collaborative sites globally to advance genetic discovery across all eating disorders (anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder). We will apply both novel and established methods to optimize discovery in our diverse and severely ill sample, culminating in a clinical translation summit. Our goal is to identify biologically, clinically, culturally, and therapeutically meaningful and actionable insights and rapidly transition the field from discovery to clinical translation.

PI_NAMEs: DINKLER, LISA ;MICALI, NADIA ;PETERSEN, LISELOTTE VOGDRUP;YI, LU  (contact);YILMAZ, ZEYNEP

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Adipose tissue;Alleles;Anorexia Nervosa;Atlases;Australia;avoidant restrictive food intake disorder;Behavior;Binge eating disorder;Bioinformatics;Biology;Body mass index;Brain;brain cell;Bulimia;Businesses;cell type;Clinical;Clinical Research;clinical translation;cohort;Collection;Communities;community partners;comorbidity;Data;Denmark;Diagnosis;Diagnostic;Dimensions;Disease;disorder prevention;DNA;Eating Disorders;Enrollment;Environmental Exposure;Environmental Risk Factor;Etiology;evidence base;Gene Expression;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Risk;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Grouping;Heritability;Heterogeneity;Human Resources;Individual;innovation;insight;Intervention;Knowledge;Liver;marginalization;marginalized community;Mendelian randomization;Mental Depression;Mental disorders;Meta-Analysis;Metabolic;Metabolic Diseases;Methods;Mexico;Minority;minority communities;Minority Enrollment;Modeling;Molecular;molecular subtypes;Muscle;Nervous System Disorder;Neurosciences;New Zealand;novel;Participant;Pathway interactions;patient stratification;patient subsets;Pattern;Phase;Phenotype;polygenic risk score;Production;Productivity;psychiatric genomics;Psychiatry;rare variant;recruit;Regional Anatomy;resilience factor;Resources;response;risk prediction;Role;Salivary;Sample Size;Sampling;Science;Severities;sex;single nucleus RNA-sequencing;Site;social media;Stress;Stressful Event;Subcellular Anatomy;Sweden;symposium;Symptoms;Taxonomy;Therapeutic;therapy development;Thinking;Tissues;trait;Underrepresented Populations;Variant;Weight Gain;working group

PROJECT_TITLE: 3/3 Eating Disorders Genetics Initiative 2 (EDGI2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Anhedonia, the inability to anticipate or experience pleasure, emerges in adolescence, often heralds the onset of more severe psychopathology such as mood disorders and psychosis, and remains poorly understood. Atypical stress response and related dysregulation of neurobiological mechanisms have been proposed as key contributors to anhedonia. The proposed project will examine the individual and interactive roles of physiological and neural mechanisms associated with acute stress experiences to the severity and maturational trajectory of anhedonia in adolescence, thereby potentially informing the development of novel prevention and intervention strategies.

PI_NAMEs: BELGER, AYSENIL  (contact);ROUBINOV, DANIELLE S.

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Acute;acute stress;Adolescence;Adolescent;Adrenal Glands;Age;Anhedonia;Autonomic nervous system;behavior test;Biological;biological adaptation to stress;Biological Markers;biotypes;Buffers;Calibration;Characteristics;Clinical;Clinical assessments;clinical predictors;cognitive testing;Complex;critical developmental period;Development;Diagnostic;disability;Early identification;Endocrine;experience;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Individual;Inferior;Intervention;Longitudinal Studies;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mediating;Modeling;Mood Disorders;mood regulation;multimodality;neural;neural circuit;neurobiological mechanism;Neurobiology;neuromechanism;novel;Onset of illness;Outcome;Parasympathetic Nervous System;Patient Self-Report;Pattern;Physiological;Pituitary Gland;pleasure;Prevention strategy;programs;Psychopathology;Psychoses;Puberty;Quality of life;Research;resilience biomarker;response;Risk;Risk Factors;Role;Severities;sex;Stress;stress reactivity;Stress Tests;stressor;Surveys;Sympathetic Nervous System;symptomatology;System;Time;Youth

PROJECT_TITLE: Multisystem Stress Response Biotypes: Deriving Novel Physiological and Neural Risk Factors for Anhedonia in Adolescence

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative Viruses and bacteria underlie different human diseases, imposing a major, continual health threat. We propose to develop novel computational methods to detect and quantify microbial genes in human diseases. These methods will unravel new roles of microbes in human diseases and can ultimately lead to biomarker discovery and development of new therapeutic strategies.

PI_NAMEs: AUSLANDER, NOAM  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Address;Adopted;Adverse event;Affect;Bacteria;biomarker development;biomarker discovery;cancer type;Communities;computer framework;Computing Methodologies;Data;Databases;deep learning;deep learning model;Detection;detection method;Development;Diagnosis;diagnostic strategy;Disease;Disease Marker;Disease Outcome;disease prognosis;Gene Expression;Genes;Goals;gut microbes;gut microbiome;Health;Homologous Protein;Human;human disease;human RNA sequencing;human tissue;Immune response;Immune System Diseases;improved;innovation;Intervention;Link;Machine Learning;Malignant Neoplasms;Maps;metagenomic sequencing;Methods;Microbe;microbial;Modeling;novel;novel diagnostics;novel therapeutic intervention;Outcome;Pathogenicity;Patients;Peptides;prognostication;Protein Databases;Proteins;Publishing;rapid detection;Research;Research Personnel;response;RNA;Role;sequencing platform;Shotgun Sequencing;Shotguns;software development;Techniques;Technology;Tissues;transcriptome sequencing;treatment strategy;user friendly software;Viral;viral detection;Virus

PROJECT_TITLE: Computational methods for discovery of disease-modulating microbial genes

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: MD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Nutrition;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project will examine the role of phosphate in vascular smooth muscle cell calcification and the potential of protein therapy to reduce calcification. The proposed protein therapy would include reestablish fetuin-A to its native levels to treat smooth muscle cell calcification in patients with the comorbidities of heart disease and chronic kidney disease. Through a collaboration with MSU Extension we will work to increase the diversity of the biomedical workforce while allowing the participants to give back to their communities and help older generations.

PI_NAMEs: HENDRIX, CHARTRISA LASHAN (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: absorption;Address;Advocate;African American;African American population;Area;Arteries;Atherectomy;Back;Basic Science;Black American;black men;Blood;blood filter;calcification;Calcium;calcium phosphate;Cardiac health;Cardiovascular Diseases;career;catalyst;caucasian American;Cause of Death;Cells;Chronic Kidney Failure;Clinical;Collaborations;Communities;Community Health;Community Health Education;comorbidity;Dairy Products;Dedications;Deposition;Disease;Disparity;Elements;Ensure;Environment;ethnic minority;Excretory function;experience;First Generation College Students;Food;food desert;Generations;graduate school;Habits;Health;health disparity;Health Food;Heart Diseases;Heart Rate;Hemodialysis;High School Student;Hispanic Populations;Industrialization;inhibitor;inorganic phosphate;interest;Intervention;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Latino Population;Leadership;Literature;Lived experience;Liver;Low income;Maintenance;male;Meat;Meat Products;mechanotransduction;Mentors;Minerals;Mississippi;Modeling;Osteoblasts;Outcome;Participant;particle;Patients;peer coaching;Persons;Phenotype;Physiological;Population;Poverty Areas;preference;Process;programs;Proteins;Publishing;Research;Research Personnel;Research Project Grants;Role;rural area;Rural Community;Scientist;Serum;Signal Pathway;Smooth Muscle Myocytes;Stents;Stream;Stroke;Students;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Urine;Vascular calcification;Vascular Smooth Muscle;volunteer;Woman;Work;α-Fetoproteins

PROJECT_TITLE: Building Healthy Habits for Heart Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Radiation Oncology;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  We discovered that suppressing UNC45A in mouse in vivo syngeneic TNBC tumors triggers a drastic reprogramming of the immune-suppressive tumor microenvironment into a more immune- responsive one. In addition, loss of UNC45A hampers the ability of cancer cells to repair ionizing radiation (IR)-induced DNA damage and sensitizes TNBC models to radiation therapy. In this application, we propose that UNC45A is a promising novel immunotherapeutic target and that its inhibition, in combination with IR therapy, will reduce the TNBC burden.

PI_NAMEs: CHADLI, AHMED  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: aggressive breast cancer;anti-PD-L1;Antitumor Response;ATR gene;B-Lymphocytes;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast tumorigenesis;Cancer Burden;cancer cell;Cause of Death;CD8-Positive T-Lymphocytes;Cell Cycle;Cell division;cell killing;Cell Physiology;Cell Proliferation;Cells;CHEK1 gene;ChIP-seq;Clinical;CSF3 gene;cytokine;Cytotoxic T-Lymphocytes;Data;Disease;DNA;DNA Damage;DNA Repair;fighting;Fostering;Functional disorder;Genes;Genetic Transcription;Genomics;Genotoxic Stress;Immune;immune checkpoint;immune checkpoint blockade;Immune system;Immune Tolerance;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Infiltration;innovation;Ionizing radiation;Left;Macrophage Colony-Stimulating Factor;Malignant Breast Neoplasm;Malignant Neoplasms;Mitosis;Molecular;Molecular Chaperones;Mus;Myelogenous;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;neutrophil;Normal Cell;novel;Nuclear;Nuclear Receptors;nucleic acid delivery;Outcome;Pathway interactions;patient subsets;Patients;Phosphorylation;Phosphotransferases;Play;Population;programmed cell death ligand 1;programs;promoter;Proteins;Proteomics;Protocols documentation;PTGS2 gene;Radiation Induced DNA Damage;Radiation therapy;Refractory;Relapse;repaired;S100A9 gene;single-cell RNA sequencing;Small Interfering RNA;Suspensions;System;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapy resistant;translational potential;Transplantation;triple-negative invasive breast carcinoma;tumor;tumor eradication;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Women's mortality

PROJECT_TITLE: Suppressing the Co-chaperone UNC45A reprograms the immunosuppressive tumor microenvironment to fight Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Few neurological conditions are as complex and devastating as stroke. It is a major cause of disability in the United States and in the aging population of veterans. While there have been important strides taken toward optimizing functional recovery, a substantial proportion of stroke survivors continue to experience long-term motor disability. The goal of this proposal is to develop a better neurophysiological model of the circuit basis of recovery and to use this to test new therapeutic approaches. We hope to use this knowledge to create novel therapies to promote motor recovery. 1

PI_NAMEs: GANGULY, KARUNESH  (contact)

PROJECT_TERMS: Affect;aging population;Agonist;Alzheimer's Disease;Alzheimer's disease test;Animals;biceps brachii muscle;Brain;Brain Stem;Chronic;chronic stroke;Clinical;clinically relevant;Communication;Complex;Data;design;disability;Epilepsy;Equilibrium;experience;experimental study;Fiber;Flexor;Frequencies;functional improvement;gain of function;Goals;grasp;Hand;Impairment;improved;Intervention;kinematics;Knowledge;Label;loss of function;Measures;Medial;Methods;military veteran;Modeling;Monitor;Motor;motor deficit;Motor disability;motor recovery;Movement;Movement Disorders;Mus;Muscle;Nerve Growth Factor Receptors;Nervous System Disorder;neuroimaging;Neurologic;neuronal survival;neurophysiology;neurotrophic factor;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;partial recovery;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;post stroke;receptor;Recovery;Recovery of Function;Rehabilitation therapy;Research;research clinical testing;restoration;Reticular Formation;Shoulder;Site;small molecule;Stroke;stroke model;stroke patient;stroke survivor;Synapses;synergism;temporal measurement;Testing;Thalamic structure;Therapeutic;Time;Training;United States;Upper Extremity;Veterans;Viral;Virus

PROJECT_TITLE: Neurophysiological Basis for Enhancing Motor Recovery After Stroke

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The processes of learning and memory can be shaped by internal and external contextual cues. State- dependent learning occurs when learning happens while the subject is in a specific internal state (e.g. intoxication) and the memory is only recalled when the subject is in the same internal state. This project aims to develop a molecular understanding of how state is encoded and how it modulates the processes of learning and remembering.

PI_NAMEs: BETTINGER, JILL C (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Alcoholic Intoxication;analog;Animal Testing;Animals;Association Learning;Attenuated;Behavior;Caenorhabditis elegans;Cues;Dependence;Development;Dopamine;Environment;Ethanol;Event;experience;Failure;Food;forgetting;Genetic;Goals;Human;Hunger;insight;Intoxication;Invertebrates;learned behavior;Learning;Memory;memory encoding;memory recall;Modeling;Modification;Molecular;Moods;Nature;Nematoda;Nervous System;neural circuit;Neurons;neurotransmission;Norepinephrine;novel;Octopamine;Olfactory Learning;Pathway interactions;Peptide Signal Sequences;Peptides;Pharmaceutical Preparations;Process;receptor;Recording of previous events;response;Shapes;Signal Transduction;social situation;Specificity;Starvation;System;Temperature;Testing;Training;Work

PROJECT_TITLE: State-dependent modulation of learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Periodontitis afflicts ~ 50% of the adult population in the United States with substantial socio- economic impacts. Porphyromonas gingivalis has been strongly implicated in periodontitis. The proposed studies will decipher the regulatory role of a novel signaling pathway that controls the lipopolysaccharide driven pathoadaptation and pathogenesis of Pg, contributing to periodontitis progression.

PI_NAMEs: MORADALI, FATA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adenosine Monophosphate;Adult;Affect;Anabolism;Animal Model;Applications Grants;Biochemical;Biological;Biological Assay;Cell Culture Techniques;Cell model;Chromatography;Chronic;chronic infection;Communities;complement system;cytokine;Data;Defense Mechanisms;defense response;Development;Dinucleoside Phosphates;Disease;Disease Progression;economic impact;Environment;Enzymes;Exhibits;Fractionation;Generations;Genes;Genetic;Goals;Gram-Negative Bacteria;Host Defense;Human;immunoregulation;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammation;Inflammatory;Investigation;Laboratories;Learning;Light;Link;Lipid A;Lipids;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;Mammals;Mediating;Methodology;Methods;microorganism;Modification;Molecular;mouse model;mutant;Mutation;new therapeutic target;novel;novel strategies;Oligosaccharides;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Periodicity;Periodontal Pocket;Periodontitis;periodontopathogen;Phenotype;phosphoric diester hydrolase;Play;Polysaccharides;Population;Porphyromonas gingivalis;Preparation;Production;Protein Biosynthesis;Protein Isoforms;Proteins;receptor;Regulation;Regulator Genes;Research;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;socioeconomics;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;System;Systemic disease;Techniques;Testing;Time;Tissues;TLR4 gene;Tooth structure;United States;Variant;Whole Blood

PROJECT_TITLE: Pathoadaptive Modulation of Porphyromonas gingivalis Lipopolysaccharide Structure and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MORGANTOWN

ORG_DEPT: CHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The proposed work will produce a powerful technology platform that opens the door to the study of structure establishment by functional nucleic acids. The technology provides the solution to the unmet need to resolve oligonucleotide structural transformations, co-existing solution structures, and conformer flexibility with ultra-high sensitivity. Unleashing the true potential of structure establishment analyses for functional nucleic acids will have an indelible impact on the development of new therapeutic strategies for diverse diseases. Project Narrative Page 9

PI_NAMEs: LI, PENG ;ROBART, AARON REIGH;VALENTINE, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acoustics;Address;blind;Blood capillaries;Catalytic DNA;Catalytic RNA;Characteristics;Complex;computerized data processing;conformer;Coupled;Coupling;COVID-19 pandemic;Cryoelectron Microscopy;Data;Data Analyses;data exchange;Data Set;design;Deuterium;Deuterium Exchange Measurement;Development;Devices;Diagnostic;diagnostic tool;Disadvantaged;Disease;Ensure;flexibility;Fluorescence Resonance Energy Transfer;Gases;hairpin ribozyme;Heterogeneity;human disease;Hydrogen;improved;insight;instrumentation;interest;Introns;ion mobility;ionization;ionization technique;Ions;kinetic model;Kinetics;Label;Ligand Binding;Maps;Mass Spectrum Analysis;Measurement;Methodology;Methods;Microfluidic Microchips;Modeling;Molecular Conformation;new technology;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;nucleic acid structure;Nucleic Acids;Oligonucleotides;Pathway interactions;Performance;Phase;Physiologic pulse;Population;post-COVID-19;Procedures;Process;process optimization;Research;Research Personnel;Resolution;RNA Stability;Roentgen Rays;Role;Running;Signal Transduction;Solvents;Source;Specificity;Spectrometry;Stream;structural biology;Structure;System;Systems Integration;Techniques;Technology;technology development;technology platform;Therapeutic;three dimensional structure;Time;tool;vibration;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Developing an integrated system for detailing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Congenital disabilites are often linked to defects on the development of the neural crest, a group of migratory stem cells that give rise to the craniofacial skeleton. Studying the molecular mechanisms controlling the formation of these cells can reveal the genetic causes of craniofacial diseases. This knowledge can improve diagnosis, treatments, and guide stem cell differentiation for the development of new therapeutic strategies.

PI_NAMEs: SIMOES-COSTA, MARCOS  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Affect;Architecture;Binding;Binding Proteins;Birds;CCCTC-binding factor;cell type;Cells;Cephalic;Characteristics;Chromatin;Chromatin Loop;Chromatin Modeling;chromosome conformation capture;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;CRISPR/Cas technology;Data;Defect;Development;Diagnosis;diagnostic strategy;Dimensions;disability;Disease;Distal;Distal Enhancer Elements;DNA;DNA Sequence;DNA-Protein Interaction;Embryonic Development;embryonic stem cell;Enhancers;Etiology;experimental study;Family;Future;Gene Activation;Gene Expression;gene regulatory network;Genes;Genetic;Genome;Genome engineering;genome-wide;Genomics;Human;improved;In Vitro;Individual;Intervention;Knowledge;Link;loss of function;Mediating;Molecular;Molecular Conformation;Mutation;Neural Crest;Neural Crest Cell;neurodevelopment;Neurophysiology - biologic function;novel diagnostics;novel therapeutic intervention;Nuclear;Organ;Pathogenesis;Pattern;Play;prevent;Process;programs;promoter;Proteins;Protocols documentation;Regulatory Element;Research;Role;Shapes;Signal Transduction;Skeleton;Societies;Specific qualifier value;stem cell differentiation;stem cell population;stem cells;System;Testing;TFAP2A gene;Therapeutic;Tissues;transcription factor;Work;YY1 Transcription Factor

PROJECT_TITLE: Architecture and function of the neural crest genome

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Exposure to smoke emitted from wildfires has been linked to a variety of health effects, including increased risks associated with respiratory viral infections, thus presenting a critical public health concern. Using human in vivo and in vitro models, the studies in this application will provide a comprehensive characterization of antiviral defense response changes associated with woodsmoke exposure in humans and link mechanistic understanding of respiratory immune dysfunction to these exposures. This cross-disciplinary proposal brings together a diverse skill set to study a unique interface between the chemistry of wildfire smoke and clinically important outcomes of influenza infections.

PI_NAMEs: REBULI, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affect;Air;air filter;Air Pollutants;ambient air pollution;anthropogenesis;Anti-viral Response;Antibodies;Antibody Formation;Aromatic Polycyclic Hydrocarbons;Attenuated;Automobile Driving;Biological;Biological Markers;biomarker signature;Biomass;Cell Count;Cell Culture Techniques;Chemicals;Chemistry;climate change;Clinical;clinically relevant;Complex;Complex Mixtures;Computer Analysis;Computer Models;Coupled;Data;defense response;Disease Outbreaks;Disease Outcome;Elements;Epidemiology;epidemiology study;Epithelial Cells;experience;exposed human population;Exposure to;extracellular vesicles;fine particles;Gene Expression;Genes;Health;healthy volunteer;Host Defense;Human;Human Volunteers;Immune;Immune response;Immune System Diseases;Immunity;Immunologic Markers;In Vitro;in vitro Model;in vivo;Infection;Inflammatory Response;Influenza;influenza infection;influenzavirus;insight;Investigation;Knowledge;Link;Liquid substance;live attenuated influenza vaccine;Mediating;Mediator;metabolomics;Metals;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;Mucous Membrane;multiple omics;Nasal Epithelium;Nose;Outcome;Pathway interactions;Pattern;peripheral blood;Physical condensation;Placebos;Plastics;pollutant;Population Growth;predictive marker;Predisposition;Proteins;Proteomics;Public Health;public health research;Publishing;Randomized;Research;Research Personnel;respiratory;Respiratory Mucosa;respiratory virus;response;Risk;Sampling;sex;simulation;Site;skills;Smoke;Source;Structure of mucous membrane of nose;Symptoms;System;Time;Tissues;tool;Toxic effect;transcriptomics;translational impact;Translational Research;Viral;Viral Markers;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;volunteer;Wildfire;Wood material;wood smoke

PROJECT_TITLE: Effects of wildfire smoke on respiratory antiviral defense responses

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study uses AI methods to anonymize the faces and voices of children with ASD in videos while preserving critical information needed for the ASD diagnostic process. We use these methods to develop and test new, anonymized assessment methods based on crowdsourcing and computational prediction. Finally, by co- designing human-in-the-loop tools with parents and clinicians to privatize videos, we develop more usable and mature workflows that can make real-world anonymization a practical reality.

PI_NAMEs: JAIN, EAKTA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 12 year old;Acceleration;Address;Administrator;Adult;Age;Algorithms;Architecture;Area;Authorization documentation;autism community;autism spectrum disorder;autistic children;Behavior;Behavior assessment;Behavior Disorders;Behavioral;care providers;Caregivers;caregiving;Caring;Child;clinical training;Communities;Computing Methodologies;Crowding;crowdsourcing;Data;Data Set;data sharing;deep neural network;design;Detection;Development;Diagnosis;Diagnostic;diagnostic tool;Drops;Ecosystem;Educational Materials;Effectiveness;Equilibrium;Evaluation;expectation;Face;Facial Expression;Family;Feedback;Focus Groups;gaze;generative models;Geometry;Goals;Guidelines;Head;Healthcare;heterogenous data;Human;human-in-the-loop;improved;Injections;insight;Investigation;Knowledge;large scale data;life span;Lived experience;Machine Learning;Measures;Mental Health;Methods;microphone;Modeling;Nature;Network-based;neural network architecture;Neural Network Simulation;novel;Outcome Study;Parents;patient privacy;Patient Recruitments;Patients;Performance;preservation;Privacy;Privatization;Process;Process Assessment;prototype;Readability;real world application;Research;Research Personnel;Rest;Semantics;Services;Severities;Surface;Surveys;Techniques;Testing;Text;Therapeutic;tool;Training;Training and Education;usability;user centered design;Video Recording;Visual;Visualization;Voice;Work

PROJECT_TITLE: AVAIL: Anonymization of Videos using AI for Large scale data sharing

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Hodgkin's Disease;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Project Narrative EBV infection usually has a benign outcome, yet 1.5% of all cancer worldwide are associated with EBV infection, including Non-Hodgkin’s Lymphoma (NHL) and Hodgkin’s disease (HD). This proposal will reveal new mechanisms regulating host-virus interactions that contribute to EBV lymphomagenesis.

PI_NAMEs: TEMPERA, ITALO  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Architecture;B lymphocyte immortalization;B lymphoid malignancy;B-Lymphocytes;Benign;Binding;CD80 Antigens;Cell membrane;Cell Nucleus;Cell Proliferation;Cells;Cellular biology;Chromatin;Chromatin Loop;Chromatin Structure;clinically relevant;cytotoxicity;Data;Development;Epigenetic Process;epigenome;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;FDA approved;Gene Expression;Genes;Genome;Hi-C;Hodgkin Disease;Human Herpesvirus 4;in vivo;infected B cell;Infection;Integration Host Factors;LMP1;Lymphomagenesis;Malignant Neoplasms;Metabolic;Molecular;Molecular Conformation;mouse model;Mus;Non-Hodgkin's Lymphoma;novel;Oncogenic;Oncoproteins;Outcome;PARP inhibition;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;programs;Proliferating;protein expression;Publishing;Repression;Sampling;Signal Pathway;T-Lymphocyte;Testing;Therapeutic;therapeutic target;three dimensional structure;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;tumor;tumor growth;Tumor Volume;tumorigenesis;Viral Proteins;virology;Virus;virus host interaction;Work;YY1 Transcription Factor

PROJECT_TITLE: Remodeling of the host epigenome during EBV infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Lung;Lung Cancer;Opioids;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PHR: Narrative Over the past two decades, prescription opioid use in the US has sharply risen, with over 17% of Americans now annually using these medications, prompting its classification as a public health emergency. Recently, the International Agency for Research on Cancer (IARC) classified use of opium (natural source for many opioids) as "carcinogenic to humans" raising concerns on how using prescription opioids may relate to subsequent cancer risk, given their close similarity in composition and mechanisms of action. The Opioid Cohort Consortium (OPICO) project will analyze over 1.7 million people from existing cohort studies in the United States, Europe, and Australia to assess whether use of prescription opioids may increase risk for specific cancers and provide robust evidence that could aim in developing national prevention strategies and targeted early detection policies to mitigate the future burden of the current opioid crisis.

PI_NAMEs: SHEIKH, MAHDI  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;age group;Alcohols;American;Australia;Biology;Biometry;cancer classification;cancer epidemiology;Cancer Etiology;cancer risk;carcinogenicity;Carcinogens;Chronic;chronic pain;Classification;Clinical Pharmacology;Code;cohort;Cohort Studies;Collaborations;comorbidity;Confounding Factors (Epidemiology);Control Groups;Country;Data;data harmonization;Databases;demographics;Dose;Early Diagnosis;Esophagus;Ethnic Population;Europe;Event;Exhibits;experimental study;follow-up;Foundations;France;Future;Genetic;genetic epidemiology;Health;Health Status;Healthcare;Human;Incidence;Individual;innovation;interdisciplinary approach;International;International Agency for Research on Cancer;Link;Malignant neoplasm of esophagus;Malignant neoplasm of larynx;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medicine;Methodology;Methods;Modeling;morphine equivalent;Natural Source;non-opioid analgesic;novel;Opioid;Opioid agonist;opioid epidemic;opioid mortality;opioid use;Opium;opium use;Outcome;overdose death;Pain;Pancreas;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phase;Pilot Projects;Policies;Population;prescription opioid;Prevention strategy;prospective;Prospective cohort;Prospective, cohort study;Protocols documentation;Public Health;public health emergency;rare cancer;Recommendation;Records;Registries;Residual state;Resources;response;Risk;Smoking;Source;Statistical Methods;synthetic opioid;Time;Tobacco;Toxic effect;tumor initiation;Tumor Promotion;United States;Urogenital Cancer;Variant;Work

PROJECT_TITLE: The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Placement of orthopaedic implants, such as a K-wires and screws, is a common surgical task, and accurate placement is critical to the success of a wide range of orthopaedic procedures. However, the rate of screw misplacement is highly variable which can lead to poor outcomes. In this proposal we will develop and evaluate a system that should improve the surgeon’s ability to accurately place the screw while minimizing radiation dose to the patient and surgeon.

PI_NAMEs: CLEARY, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Adopted;Anatomy;arm;bone visualization;Cadaver;Capital;Child;Childhood;Clinical;clinical practice;Clinical Research;Competence;Computer software;Cone;cost;deep learning model;Devices;Doctor of Philosophy;Dose;experience;Exposure to;Femur;first-in-human;Fracture;Future;Geometry;Goals;Hip region structure;Image;image guided;image guided intervention;image reconstruction;image registration;Image-Guided Surgery;imaging capabilities;imaging modality;Implant;Implantation procedure;improved;Injury;instrument;International;Intramedullary Nailing;Joints;Lead;Medical;Meta-Analysis;Methodology;Methods;Modeling;multidisciplinary;Neck;Nerve;novel;open source;Operating Rooms;Operative Surgical Procedures;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Outcome;Patients;Pediatric Surgical Procedures;Pelvis;Physics;Positioning Attribute;Principal Investigator;Procedures;professor;Protocols documentation;Provider;Radiation;Radiation Dose Unit;Radiation exposure;reconstruction;Research Personnel;Risk;Robot;robot assistance;Robotics;Roentgen Rays;Rotation;sample fixation;Second Look Surgery;Source;Sports Medicine;Structure;success;Surgeon;Surgical Instruments;System;Systems Integration;Techniques;Technology;Three-Dimensional Image;Three-Dimensional Imaging;tibia;tomosynthesis;Translating;Trauma;trend;Vertebral column;Work;X-Ray Medical Imaging

PROJECT_TITLE: Image-guided robotic assistance to improve precision and reduce x-ray dose in orthopedic surgery for pediatric SCFE

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Hematology;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative While platelets are critical for maintaining hemostasis and vascular integrity, there is a significant unmet need in identifying new targets that modulate platelet counts from their precursor cells, megakaryocytes. We recently discovered that membrane polyunsaturated fatty acids (PUFAs) in megakaryocyte progenitors regulate megakaryocyte development and platelet production and represent a novel target for modulating megakaryopoiesis and platelet counts. The experiments outlined in this proposal will provide a detailed and actionable roadmap of the mechanisms by which both human and murine megakaryocytes and progenitors accumulate and utilize PUFAs to drive platelet production so that we can ultimately enhance and/or fine tune megakaryocyte and platelet production to improve outcomes for patients with diverse thrombotic and platelet disorders.

PI_NAMEs: MACHLUS, KELLIE RAE (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Abnormal Platelet;Address;Adverse effects;Adverse event;Bar Codes;Blood Coagulation Disorders;Blood Platelet Disorders;Blood Platelets;Blood Vessels;CD34 gene;CD36 gene;cell type;Cells;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Data;desaturase;Development;Diet;Dietary Fatty Acid;Dietary Intervention;Diffusion;Dimerization;Disease;Enzymes;experimental study;Fatty Acids;Flow Cytometry;Gene Expression;Hematopoietic stem cells;Hemorrhage;Hemostatic function;Human;human induced pluripotent stem cells;Impairment;improved outcome;In Vitro;in vitro Model;in vivo;Individual;leukemia virus;Libraries;lipidomics;Lipids;loss of function mutation;Megakaryocytes;Megakaryocytopoieses;Membrane;Membrane Fluidity;Membrane Lipids;Membrane Microdomains;Modification;mouse model;Mus;novel;Ontology;Organoids;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Plasma;Platelet Count measurement;Ploidies;Polyunsaturated Fatty Acids;precursor cell;Process;Production;progenitor;Proteins;Publishing;receptor;Risk;Role;Saturated Fatty Acids;Signal Transduction;Source;Specificity;stem cells;targeted treatment;Techniques;Testing;Therapeutic Intervention;Thrombocytopenia;Thrombopoiesis;Thrombopoietin;Thrombosis;transcriptome sequencing;Up-Regulation;uptake;Very Long Chain Fatty Acid;Virus Receptors

PROJECT_TITLE: Elucidation of the mechanisms by which fatty acids drive megakaryopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This proposal is relevant to public health for understanding the link between the epigenetic modifications and chromatin-remodeling that control many genes that are aberrantly expressed or turned off in the lung vascular cells in pulmonary arterial hypertension (PAH). This project will also carry out the feasibility studies evaluating the combination therapy using gene therapy and small compounds as therapeutic strategies to address the unmet need for effect therapies that target lung vascular cells dysfunction in PAH disease.

PI_NAMEs: HADRI, LAHOUARIA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Ablation;Address;Animal Model;Apoptosis;ARID Domain;ARID1A gene;ATAC-seq;Blood Vessels;Cardiopulmonary;Cardiovascular system;cell growth;Cessation of life;Chemosensitization;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chronic;Clinical;Combined Modality Therapy;curative treatments;Data;Development;Disease;DNA Methylation;effectiveness evaluation;Enhancers;Epigenetic Process;epigenetic regulation;Exhibits;Exposure to;Feasibility Studies;Foundations;Functional disorder;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene therapy;Genes;Genetic Transcription;Goals;Growth;histone methyltransferase;Homeostasis;Homologous Gene;Human;human model;hypertension treatment;Hypoxia;Impairment;improved;inhibitor;insight;Knowledge;Life;Link;Lung;Malignant Neoplasms;Mediating;Medicine;Modeling;Modification;Molecular;Mus;new therapeutic target;novel;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Physiology;Play;Pneumonectomy;Prevention;Proliferating;Proteins;Public Health;pulmonary arterial hypertension;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular disorder;pulmonary vascular remodeling;Rattus;Regulation;Research;Research Support;Resistance;right ventricular failure;Role;Sampling;small hairpin RNA;Smooth Muscle Myocytes;Stress;Structure;Sucrose;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Tissue-Specific Gene Expression;transcriptome sequencing;transcriptomics;Treatment Efficacy;Tumor Suppressor Proteins;Vascular Diseases;Vascular remodeling;Vascular resistance;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;vector

PROJECT_TITLE: The Chromatin Remodeling Factor ARID1a and the Epigenetic Landscape In Pulmonary Arterial Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Disrupted sleep and circadian patterns are a primary feature of bipolar disorder and may represent a significant mechanistic treatment target. Bipolar Disorder I may be associated with increased sensitivity to light, but this has not been comprehensively assessed with the most direct measure of light sensitivity: the post-illumination pupil response (PIPR). In this study we will compare light sensitivity between people with bipolar disorder I versus healthy controls and determine if light sensitivity drives daily variability in sleep, mood and energy.

PI_NAMEs: BURGESS, HELEN JULIA (contact);SPERRY, SARAH HAVENS

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TITLE: Light Sensitivity in Bipolar Disorder: A Potential Driver of Variability in Sleep, Mood and Energy


ORG_CITY: BRONX

ORG_DEPT: UROLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative: Patients undergoing pelvic surgeries are confronted with a considerable risk for developing both bladder and erectile dysfunction, despite the utilization of nerve-sparing techniques. With this in mind, the primary objective of this proposal is to examine fundamental mechanisms that contribute to the simultaneous manifestation of these post-surgical urogenital complications. Our central hypothesis posits that an abnormal inflammatory response within the major pelvic ganglia (MPG) serves as a mediator for pelvic organ cross-communication, leading to the synchronized progression of bladder and erectile dysfunction; by exploring this hypothesis, we aim to uncover potential interventions that can modulate this inflammatory response, thus potentially enhancing the post-operative urogenital function outcomes.

PI_NAMEs: DAVIES, KELVIN P (contact);SUADICANI, SYLVIA OTTILIE

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Animal Model;Animals;Anti-Inflammatory Agents;Bladder;Bladder Dysfunction;Bladder Tissue;Clinical;Communication;Data;Development;Electron Microscopy;Erectile dysfunction;experimental study;Functional disorder;Ganglia;Gene Expression Profiling;Genitourinary system;Goals;Harvest;high risk;Histologic;Hour;Impairment;improved;Inflammation;inflammatory modulation;Inflammatory Response;insight;Intervention;Laparotomy;lower urinary tract symptoms;Malignant neoplasm of prostate;Mediating;Mediator;minimally invasive;Modeling;Molecular;Molecular Profiling;Nerve;Nerve Crush;nerve injury;nerve transection;neuronal excitability;Neurons;Operative Surgical Procedures;Organ;Outcome;Pathologic;Pathology;Patients;Pelvis;penis;Pharmaceutical Preparations;Postoperative Period;pre-clinical;Quantitative Reverse Transcriptase PCR;Radical Prostatectomy;Rattus;Regulation;Reporting;Risk;Role;Severities;Signal Transduction;spared nerve;Synaptic Transmission;systemic inflammatory response;Techniques;Testing;Time;Tissues;transcriptome;Trauma;Treatment outcome;Urethra;Western Blotting

PROJECT_TITLE: Pelvic ganglia inflammation as a factor leading to organ crosstalk and coordinated development of bladder and erectile dysfunction following pelvic surgery.

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Several major health organizations have emphasized the need for obesity prevention interventions in early childhood. Parent involvement is critical for effective early childhood interventions, but few programs successfully engage parents. There is evidence that families of young children enjoy participating in playgroups, which are social and educational parent-child groups. Benefits of delivering obesity prevention content via playgroups are they overcome the need for childcare and they offer the opportunity for use of evidence based parenting behavior techniques commonly used by family therapists. This study will test whether a playgroup intervention improves diet and activity behaviors of toddlers to a greater extent than no treatment or standard health education for parents.

PI_NAMEs: LEDOUX, TRACEY ANN (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;African;African American;Age;American;arm;Behavior;Child;Child Care;Child Rearing;Chronic Disease;Color;Communities;community organizations;Control Groups;Data;Diet;Dietary Fiber;early childhood;Education;effectiveness/implementation study;efficacy testing;efficacy trial;Elements;ethnic diversity;Ethnic Origin;evidence base;Evidence based program;experience;Family;Focus Groups;follow-up;Food;fruits and vegetables;Goals;good diet;Head Start Program;Health behavior;Health education;health organization;Health Promotion;healthy weight;Height;Hispanic;improved;in vivo;Instruction;Intervention;intervention mapping;Length;Mediating;Methods;nutrition;Nutritional;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;Parent-Child Relations;Parenting Education;Parents;Participant;Patient Self-Report;Physical activity;Pilot Projects;Play;Prevalence;prevent;Prevention;Prevention program;preventive intervention;programs;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resistance;Sampling;saturated fat;sex;skills;Sleep;social;Special Supplemental Nutrition Program for Women, Infants, and Children;Standardization;success;sugar;Surveys;sweetened beverage;Teaching Method;Techniques;Testing;Toddler;Trans Fats;treatment effect;treatment group;underserved community;Underserved Population;Unhealthy Diet;Weight;Wellness Program

PROJECT_TITLE: Reducing obesity through play: A randomized control trial

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Telehealth

ORG_CITY: CORAL GABLES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This study will evaluate the effects of Healthy Juntos, a family-based digital lifestyle intervention, in preventing increases in body mass index and improving moderate-to-vigorous physical activity, diet quality, and percentage body fat among Hispanic adolescents. It will also examine whether the intervention improves parent weight status and lifestyle behaviors, family functioning and health-related positive parenting practices. The knowledge expected to be gained from this study has the potential to transform the type of obesity and cancer prevention programs that are disseminated to improve the health of US Hispanic families.

PI_NAMEs: ST. GEORGE, SARA MIJARES (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: 15 year old;Accelerometer;acceptability and feasibility;Acculturation;Address;Adolescent;Adolescent Behavior;adolescent health;Adult;Age;Behavior;behavior change;Behavioral;Biolectric Impedance;Body fat;Body mass index;cancer prevention;Cancer Prevention Intervention;cancer risk;Cause of Death;Cellular Phone;Child Rearing;Communication;contextual factors;critical developmental period;cultural values;deprivation;design;Diet;Dietary intake;digital;digital delivery;digital health;digital intervention;Drug usage;efficacy trial;eHealth;experience;Family;Goals;Guidelines;Health;Health Promotion;Healthy Eating;healthy weight;Hispanic;Hispanic Populations;improved;indexing;Individual;innovation;Internet;Intervention;Knowledge;Life Style;lifestyle intervention;Link;Maintenance;Malignant Neoplasms;Mediating;Mediator;Metabolic;mHealth;moderate-to-vigorous physical activity;modifiable risk;Motivation;Neighborhoods;Not Hispanic or Latino;Obesity;obesity in children;obesity prevention;Outcome;parent-adolescent communication;parental involvement;Parents;Phase;Physical activity;physical inactivity;Population;post intervention;prevent;Preventable cancer cause;Prevention program;preventive intervention;primary outcome;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Recommendation;Risk;Risk Behaviors;Risk Factors;Role;secondary outcome;Self Efficacy;sex;shared decision making;skills;sociodemographics;System;theories;Unhealthy Diet;web site;Weight;Youth

PROJECT_TITLE: Efficacy Trial of Healthy Juntos: A Family-based Digital Lifestyle Intervention for Hispanic Adolescents and their Parents


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Drinking water instead of sugared beverages can help prevent obesity and dental caries, two of the most prevalent pediatric diseases, disproportionately impacting marginalized youth. This investigation will partner with schools to conduct a water-promotion intervention, targeting multiple levels of influence on student hydration. Results will determine intervention effectiveness and sustainability, within a district that has newly installed hydration stations and is operating under a policy designed to enhance healthy hydration practices and promote equitable access to water.

PI_NAMEs: BEAN, MELANIE K (contact);BRICKHOUSE, TEGWYN H

PROJECT_TERMS: Address;Behavioral;Beverages;Black race;Child;Childhood;cognitive function;Communities;community advisory board;comparison control;Consumption;contextual factors;Data;Dental caries;design;disadvantaged background;Disease;drinking;drinking water;economic disparity;Education and Outreach;Educational Curriculum;effectiveness analysis;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;elementary school;Equity;ethnic identity;Evaluation;experience;federal policy;Feedback;Flowmeters;health equity;Hydration status;implementation intervention;improved;Inequity;informant;Intake;Intervention;Interview;Investigation;Juice;Latinx;Low income;marginalization;marginalized population;Marketing;Methods;Milk;Modeling;obesity prevention;Outcome;Policies;Practical Robust Implementation and Sustainability Model;primary outcome;Procedures;process evaluation;programs;Psychological reinforcement;Public Health;racial identity;Random Allocation;Randomized, Controlled Trials;Research Methodology;Resources;Sales;Scanning;school district;school environment;Schools;secondary outcome;Security;social;Social Marketing;Students;success;sugar;Surveys;sweetened beverage;teacher;third grade;Training;trial design;Virginia;Water;Water consumption;Work;Youth

PROJECT_TITLE: Advancing Water Security: A Community Participatory School-Based Hydration Intervention

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative  Bronchopulmonary dysplasia (BPD) is a common lung complication in premature infants, impairing their lung development and long-term respiratory health. Our research focuses on mitochondrial dysfunction and specific genetic variations called mtDNA haplogroups, which contribute to the severity of BPD. By investigating the role of mtDNA haplogroups and exploring potential therapeutic interventions, we aim to develop personalized strategies that can mitigate the risk of BPD and improve outcomes for premature infants.

PI_NAMEs: KANDASAMY, JEGEN  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Agonist;Air;Alveolar;alveolar epithelium;Alveolus;Antioxidants;ANXA5 gene;Apoptosis;Apoptotic;Asthma;Bioenergetics;Biogenesis;Biological Assay;Birth;Blood Platelets;Bronchopulmonary Dysplasia;Cell Death;Cells;Complication;cytokine;Data;Development;DNA;DNA Damage;Electron Microscopy;Electron Spin Resonance Spectroscopy;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Ethnic Origin;Exhibits;extreme prematurity;Flow Cytometry;Generations;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Goals;Haplogroup;hormonal signals;Human;Hyperoxia;Immunoassay;Impairment;improved;improved outcome;Infant;Inflammation;Inflammatory;Inherited;Injury;Knowledge;Life;Lung;lung development;lung health;lung injury;Measurement;Measures;Mediating;Mediator;Mesenchymal Stem Cells;Methylation;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;morphometry;Mus;Neonatal;Newborn Infant;normoxia;novel;Nuclear;Outcome;oxidant stress;Oxidants;Pathogenesis;Pathologic;Pattern;Perinatal;personalized strategies;Plasma;Play;postnatal;Premature Infant;Pulmonary Fibrosis;Pulmonary Pathology;Quality Control;Research;respiratory health;Risk;risk mitigation;risk stratification;Role;Saline;Severities;single cell genomics;single-cell RNA sequencing;Source;Stress Tests;surfactant;Testing;Therapeutic Intervention;Thyroid Hormone Receptor Beta;Thyroid Hormones;Triiodothyronine;Umbilicus;Variant;Venous;Western Blotting

PROJECT_TITLE: MTDNA HAPLOGROUPS IN BPD

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing an alternative strategy for radiopharmaceutical therapy that enables optimized, personalized dosing based on absorbed dose predictions. Such an approach is expected to result in durable responses in cancer patients that are typically not achieved with the fixed activity treatment commonly used in radiopharmaceutical therapy today.

PI_NAMEs: DEWARAJA, YUNI K (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: absorption;Adverse event;androgen independent prostate cancer;Antigen Receptors;Antigen Targeting;Beta Particle;Biological Markers;Bone Marrow;cancer cell;Cancer Patient;cancer therapy;clinical practice;Clinical Trials;cohort;common treatment;Complex;Coupling;cytotoxic radiation;Data;deep learning model;Deposition;Development;dosage;Dose;Dose Limiting;dosimetry;efficacy evaluation;FDA approved;FOLH1 gene;Future;Gamma Rays;Goals;Image;imaging properties;improved;In complete remission;in vivo;individualized medicine;Infiltration;innovation;kinetic model;Label;Laboratories;Lesion;Malignant Neoplasms;Marrow;Methods;Modeling;Modification;Normal tissue morphology;novel;Organ;Outcome;patient oriented;Patients;Phase I Clinical Trials;phase I trial;Phase II/III Trial;Positron-Emission Tomography;Prediction of Response to Therapy;predictive modeling;primary endpoint;Property;prostate cancer cell;Prostate Cancer therapy;Protocols documentation;Public Health;Radiation therapy;radioligand;Radiopharmaceuticals;receptor;Recommendation;Reporting;Research;response;Risk;Running;Safety;Scanning;Scheme;single photon emission computed tomography;skeletal disorder;standard care;Standardization;theranostics;Therapeutic;Time;tool;Toxic effect;Tracer;Treatment Efficacy;treatment planning;tumor;volunteer;Work;X-Ray Computed Tomography

PROJECT_TITLE: Enhancing radioligand therapy for prostate cancer with biomarker and dosimetry guided personalization

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Pharmacotherapy offers promise as an obesity treatment by limiting external drivers of overeating, promoting adherence to healthful lifestyle behaviors involved in energy balance regulation. Phentermine, the most- prescribed anti-obesity medication, is a sympathetic nervous system stimulant, yet its effects on sleep, an established behavioral determinant of diet, activity, and body weight, have not been evaluated. We propose to formally test the impact of phentermine vs. placebo on sleep and explore whether sleep during the intervention period influences the efficacy of phentermine in improving body weight, diet, and physical activity.

PI_NAMEs: ZURAIKAT, FARIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accounting;actigraphy;Address;Adherence;Adult;adult obesity;Adverse effects;Affect;Ancillary Study;arm;Arousal;Attenuated;bariatric surgery;Behavior;behavior change;Behavior Therapy;Behavioral;Body Weight;Body Weight decreased;cardiometabolism;Cell Nucleus;Clinical;Clinical Research;comorbidity;cost;Data;Diet;Disease;Dose;Drug Prescriptions;Eating;Eating Behavior;Effectiveness;energy balance;Energy Intake;experimental study;Funding;Goals;Health;Heart Diseases;heart rate variability;Hematological Disease;Home;Hunger;Hyperphagia;Hypothalamic structure;improved;Individual;insight;interest;Intervention;Investigation;Knowledge;Life Style;lifestyle intervention;Light;light intensity;Lung Diseases;Maintenance;Measures;Mediating;Melatonin;Modality;Modeling;National Heart, Lung, and Blood Institute;nerve supply;Norepinephrine;novel;Obesity;obesity treatment;obesogenic;Outcome;Overweight;Participant;Pharmaceutical Preparations;Pharmacotherapy;Phentermine;Physical activity;Placebos;poor sleep;prevent;preventable death;Prevention;primary outcome;programs;Property;Protocols documentation;randomized placebo controlled trial;Recommendation;Regulation;REM Sleep;Reporting;Research;research study;response;Role;secondary outcome;sedentary;side effect;Site;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Sleeplessness;standard of care;Stimulant;Sympathetic Nervous System;Sympathomimetics;Testing;Time;treatment duration;treatment effect;treatment response;treatment strategy;Visit;Weight;Weight maintenance regimen;Wrist

PROJECT_TITLE: SLEAP: a Sleep ancillary to the Long-term Effectiveness of the Anti-obesity medication Phentermine trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Youth with significant behavioral health needs make more clinical progress when their treatment planning is informed by ongoing quantitative data collection; however, aides often do not collect high quality data consistent with evidence-based practice. This R01 uses a randomized hybrid type 2 effectiveness-implementation pragmatic mixed-methods trial design to test a behavioral-economics informed digital health measurement feedback application (“Footsteps”) to improve implementation of data collection quality and youth mental health outcomes. This will be one of the first studies to examine the effect of theory-informed behavior change mechanisms on data collection in behavioral health care and will advance the science of digital health as a support to practitioners in implementing behavioral health evidence-based practices.

PI_NAMEs: NUSKE, HEATHER J (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: adolescent with autism spectrum disorder;Attitude;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;behavioral health;Caring;Child;Clinical;clinical care;Communication;Communities;community partners;Complex;Cost Measures;Data;Data Collection;data quality;data sharing;design;Development;digital data;digital health;effectiveness testing;electronic data;Electronic Mail;Employee;Enrollment;Evidence based practice;expectation;Feedback;follow-up;Fostering;Health Technology;Healthcare;Hour;Hybrids;implementation strategy;implementation/effectiveness;improved;improved outcome;Interview;Measurement;Measures;Mediator;Mental Health;Methods;Modeling;Motivation;Nature;Neurodevelopmental Disorder;novel;Occupations;Outcome;Outpatients;Paper;pilot trial;Population Intervention;Positioning Attribute;pragmatic implementation;primary outcome;Process;programs;Psychological Factors;Questionnaires;Randomized;randomized trial;Reporting;Resources;Schools;Science;Self Efficacy;Services;skill acquisition;skills;Supervision;Surveys;Symptoms;System;Testing;theories;Therapeutic;Time;tool;treatment optimization;treatment planning;treatment strategy;trial design;user centered design;Vertebral column;week trial;Work;Youth

PROJECT_TITLE: RCT of a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ORG_CITY: Princeton

ORG_DEPT: BIOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Metabolic syndrome affects greater than one in three individuals in the United States, increasing risk for pathogenic infections, heart disease, diabetes, and other issues that affect health. The risks associated with metabolic syndrome and the responsiveness to interventions (e.g., dietary interventions) vary substantially among individuals, yet the biological factors driving this variation are poorly understood. The proposed work will employ a manipulative experiment in mice to determine how high-fat diets drive adaptive evolution of gut bacterial species and how bacterial adaptation to high- fat diets affects metabolic traits in hosts, thereby revealing how strains in the microbiome contribute to host metabolic syndrome.

PI_NAMEs: MOELLER, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Adult;Affect;Automobile Driving;Bacteria;bacterial fitness;Bacterial Genome;base;Biological Factors;Characteristics;cost;cytokine;Data;Diabetes Mellitus;Diet;Dietary Intervention;Ecological Change;Evolution;experience;experimental study;Fat-Restricted Diet;Fatty acid glycerol esters;Feedback;fitness;Gene Expression;Generations;Genes;Genetic Polymorphism;Genetic Variation;Genome;genome sequencing;genomic locus;genomic signature;Genomics;Germ-Free;gut bacteria;gut microbes;gut microbiota;Health;Heart Diseases;High Fat Diet;Horizontal Disease Transmission;human microbiota;Immune response;Inbred Mouse;Individual;individual response;Infection;Intervention;Intestines;Knowledge;Link;Mammals;Measures;Metabolic;Metabolic syndrome;metabolome;metagenome;Metagenomics;microbial;microbiome;microbiota;Minority;Morphology;Mouse Strains;Mus;Natural Selections;Needles;Obesity;Outcome;Pathogenicity;Pathway interactions;Phenotype;Plasmids;Population;Production;Proliferating;Reproducibility;Research;resident commensals;Resolution;response;Risk;Robotics;Serum;Shapes;Testing;trait;transmission process;Transplantation;Unhealthy Diet;United States;Variant;whole genome;Work

PROJECT_TITLE: The genomics and consequences of gut bacterial adaptation to high-fat diets

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This project aims to develop and apply advanced causal inference methods and computational algorithms to em- power the analysis of large-scale genetic and multi-omics data in multi-ethnic and historically underrepresented populations. These methods will help identify causal omics-level biomarkers for non-invasive and accurate early diagnosis of Alzheimer's disease and related dementias in the preclinical phase, which might provide the best time window for early prevention and intervention.

PI_NAMEs: LIU, ZHONGHUA  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Accounting;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;analytical method;biobank;Biological;Biological Markers;blood-based biomarker;Brain;Brain Diseases;Brain Injuries;brain magnetic resonance imaging;Cause of Death;Cerebrospinal Fluid;Clinical;Cloud Computing;cloud platform;cluster computing;cohort;Computational algorithm;computational platform;Computer software;Confidence Intervals;Data Commons;Deposition;Development;diagnostic technologies;Disease;Disease Outcome;Drug Targeting;Early Diagnosis;empowerment;Ethnic Population;Etiology;Exclusion;experience;FAIR principles;functional genomics;Genetic;genetic association;Height;Heterogeneity;high dimensionality;High Performance Computing;improved;Individual;individualized prevention;innovation;Intervention;Joints;Life Expectancy;machine learning algorithm;Masks;Measures;Memory;Mendelian randomization;Methodology;Methods;Modeling;Modernization;multi-ethnic;Multiomic Data;multiple omics;Nerve Degeneration;Neurons;novel;Outcome;Pathway interactions;Performance;personalized intervention;personalized medicine;Phase;pleiotropism;Population;Positron-Emission Tomography;pre-clinical;Prevalence;Prevention;Prevention strategy;Process;Proteins;Psyche structure;Public Health;Quantitative Trait Loci;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resources;Sampling;Senile Plaques;software development;Solid;Staging;Structure;Symptoms;tau aggregation;tau Proteins;Time;Underrepresented Populations;United States National Institutes of Health;user friendly software;Washington

PROJECT_TITLE: Robust Mendelian Randomization Framework with Multi-Omics Data for Alzheimer's Disease and Related Dementias

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Strategies to shift food choices in the US toward a ‘planetary health’ dietary pattern, which is both more environmentally sustainable and healthier, are needed. This research project will use two sequential randomized controlled experiments to determine the degree to which climate-impact menu labels on fast-food restaurant menus influence the healthfulness of restaurant food choices and overall dietary intake. Results will provide critically important, timely, and actionable evidence to inform menu label policy and voluntary interventions to improve dietary quality and diet-related health of Americans while helping to address the urgent threat of climate change.

PI_NAMEs: WOLFSON, JULIA A (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;American;Behavior assessment;behavior change;behavioral outcome;Carbon;Chronic Disease;Climate;climate change;climate impact;climate-related health;Code;consumer behavior;Country;Data;design;Development;Diet;dietary;Dietary intake;Dietary Practices;Education;Environment;European;Evaluation;evidence base;experimental study;Exposure to;fast food;follow-up;Food;food consumption;Food Industry;Food Labeling;Food Policy;Food Selections;Food Services;Frequencies;Friends;Gender;Goals;Halo Effects;Health;Health Food;Health Policy;Health Promotion;Healthy Eating;Hospitals;Hour;improved;Income;indexing;Intake;interest;Intervention;Label;Lead;Light;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrition;Nutrition Labeling;Obesity;Outcome;Participant;Patient Self-Report;Perception;Policies;Policy Maker;Politics;prevent;Prevention strategy;Processed Meats;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;red meat consumption;Research;Research Project Grants;Restaurants;Sampling;Service setting;System;Time;United States;United States National Institutes of Health;Universities;warning label;Workplace

PROJECT_TITLE: A randomized-controlled evaluation of the effects of climate impact menu labels on dietary quality

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Infectious Diseases;Liver Disease;Sepsis

ORG_CITY: JOHNSON CITY

ORG_DEPT: SURGERY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Sepsis, a life-threatening condition triggered by an uncontrolled response to infection, is a leading cause of mortality in intensive care units globally. Liver dysfunction, a common complication in septic patients, significantly affects prognosis and is an independent predictor of mortality. This study uncovers the novel role of liver sinusoidal endothelial cells (LSECs) in regulating Kupffer cell zonation, bacterial clearance, and hepatic gluconeogenesis during sepsis, offering valuable insights for improving patient outcomes in this critical condition.

PI_NAMEs: WANG, XIAOHUI  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Affect;Antigen-Antibody Complex;Bacteremia;Bacterial Infections;Capillarity;Cause of Death;Cell Communication;Cell Physiology;Cirrhosis;Complication;Data;Development;Endothelial Cells;Endotoxins;Exhibits;Foundations;Functional disorder;gain of function;GATA4 gene;Genetic Transcription;Gluconeogenesis;Heat-Shock Proteins 70;Hepatic;hepatic gluconeogenesis;Hepatocyte;Immune;Immune response;Immune System Diseases;immunoregulation;Impairment;improved;improved outcome;Infection;innovation;Innovative Therapy;insight;Intensive Care Units;Investigation;Kupffer Cells;Life;Liver;Liver Dysfunction;liver function;loss of function;Measures;member;Metabolic;Metabolic dysfunction;Morbidity - disease rate;mortality;Mus;nonalcoholic steatohepatitis;novel;Nuclear Translocation;Organ;Patient-Focused Outcomes;Patients;Pattern;Phagocytes;Phagocytosis;Phenotype;Play;polymicrobial sepsis;Predisposition;Prognosis;Recovery of Function;Recycling;response;Role;Sepsis;septic;septic patients;Site;Systemic infection;Therapeutic;transcription factor;uptake

PROJECT_TITLE: Novel role of LSECs in hepatic immune and metabolic function during sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ORTHOPEDICS

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.

PI_NAMEs: BOERCKEL, JOEL D (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Actins;Actomyosin;Benchmarking;Biological Assay;Biology;Cell membrane;cell motility;cell type;Cells;Cytoskeleton;Decision Making;Engineering;Extracellular Matrix;Family;Feedback;Focal Adhesions;Image;Intercellular Junctions;Light;Lipids;Maps;mechanical force;mechanical stimulus;mechanotransduction;member;Membrane Proteins;Monomeric GTP-Binding Proteins;Motility;Natural regeneration;optogenetics;Performance;Peripheral;Photoreceptors;Physiological;Proteins;Reporter;Reporting;response;rho;Role;Signal Transduction;Stress Fibers;Technology;tool;transmission process

PROJECT_TITLE: Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Nutrition;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Glioblastoma remains one of the deadliest of human cancers despite aggressive treatment, suggesting that novel therapies are needed. We will investigate how the metabolic state of glioblastoma determines how tumors generate proteins that promote their growth and resistance to radiation and chemotherapy. Dietary manipulations may increase the efficacy of other therapies for the treatment of glioblastoma.

PI_NAMEs: AGNIHOTRI, SAMEER ;RICH, JEREMY N (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Acceleration;Adenine;aggressive therapy;Amino Acids;Antimitotic Agents;Automobile Driving;base;beta catenin;Biochemical;Biology;cancer therapy;Carbon;cell growth;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical translation;Codon Nucleotides;Complex;conventional therapy;CRISPR screen;Dependence;Development;dietary;Dietary Intervention;dietary manipulation;dietary restriction;DNA Damage;Endopeptidases;Energy-Generating Resources;Enzymes;Epigenetic Process;Essential Amino Acids;gain of function;Galloway syndrome;Genes;Genetic;Glioblastoma;Glucose;Growth;Heterogeneity;Human;Human Genome;Immune response;In Vitro;in vivo;inhibitor;Intervention;ketogenic diet;Ketones;kidney dysfunction;Life;loss of function;Lysine;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolism;Methionine;Microcephaly;Mitosis;Modification;Molecular;Molecular Target;molecular targeted therapies;mutant;Mutation;Nature;neoplastic cell;neuro-oncology;novel therapeutics;Nutrient;Oncogenic;Pathway interactions;Patients;Penetration;Phosphotransferases;PI3K/AKT;posttranscriptional;precision oncology;preclinical study;Prediction of Response to Therapy;Protein Biosynthesis;Protein Complex Subunit;protein function;Protein Kinase;Proteins;Proteome;Regulation;Reporting;Resistance;response;Role;Starvation;stem;Supplementation;targeted treatment;Therapeutic;Threonine;Transcriptional Regulation;Transfer RNA;Translating;Translations;Treatment Failure;tumor;tumor growth;tumor heterogeneity;tumor initiation;tumor metabolism;Up-Regulation;uptake;Work;Xenograft procedure;Yeasts

PROJECT_TITLE: Metabolic Control of Translation in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE IgE is an evolutionarily conserved antibody isotype well-known for its deleterious role in allergic disease but poorly characterized in other settings. Using a novel genetic approach, we found that in all conditions tested, IgE reacts to a discrete set of antigens compared to IgG, and that IgE recognition of antigen influences host response to acute inflammatory challenge. By identifying antigenic targets of IgE, we will investigate the fundamental roles played by IgE during homeostasis and host protection from disease.

PI_NAMEs: MEDZHITOV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;Affinity;Allergic Disease;Antibodies;Antigen Targeting;Antigens;B-Lymphocytes;Back;Binding;Biological;Biology;Breeding;Cell Differentiation process;Cells;comparative;Data;Data Set;Dendritic Cells;Disease;Effector Cell;environmental agent;Enzyme-Linked Immunosorbent Assay;Epitopes;Exhibits;Exposure to;Food Hypersensitivity;Genetic;genetic approach;germ free condition;Germ-Free;Half-Life;Health;Homeostasis;human model;IgE;IgE Receptors;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoprecipitation;Infection;Inflammatory;Influenza;influenza infection;influenzavirus;interest;Investigation;Knock-in Mouse;Laboratories;Lead;Literature;Mammals;mast cell;Mediating;Microscopy;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;pathogen;Pathway interactions;Phenotype;Play;polarized cell;Predisposition;Primary Infection;Production;protective effect;Reaction;Research Design;response;Role;screening;Septic Shock;Serum;Site;Source;STAT3 gene;Stimulus;Stress;Syndrome;Technology;Testing;Time;Tissues;tool;Toxin;unpublished works;Venoms

PROJECT_TITLE: Role of IgE in Homeostasis and Disease

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Rehabilitation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative People with Amyotrophic Lateral Sclerosis (PALS) have diminished verbal communication abilities that decline due to disease progression and negatively affect quality of life. Current interventions addressing this issue have limited utility in degenerative conditions such as ALS in which the speaker’s abilities continue to decline in spite of intervention. The proposed work evaluates the promise of developing new interventions that leverage communicative interactions to improve verbal communication.

PI_NAMEs: LEE, JI MIN ;OLMSTEAD, ANNE  (contact);VISWANATHAN, NAVIN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Affect;Alternative Therapies;Amyotrophic Lateral Sclerosis;Caregivers;Clinical;clinical development;Communication;Communication difficulty;Communication impairment;Complex;Degenerative Disorder;Disease Progression;dynamic system;evidence base;Family;Family member;flexibility;Goals;improved;Individual;Intervention;Language;Measures;Modeling;Neurodegenerative Disorders;novel;Oranges;Pattern;Persons;Phonetics;phonology;preference;primary caregiver;Process;Production;programs;Quality of life;Rehabilitation therapy;Reporting;Research;Resources;Spottings;Structure;success;synergism;syntax;theories;verbal;Work

PROJECT_TITLE: Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Racial and Ethnic Minority Health Research;Radiation Oncology;Rare Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Risk of death for Black patients with HPV-negative oropharyngeal cancer (OPC) is significantly worse compared to White, Hispanic, and Asian patients even after adjusting for socioeconomic, demographic and disease related effects. Survey data suggests that Black, Hispanic/Latino and White patients agree that non-White patients with cancer are more likely than White patients to receive poor quality care. <5% of the oncology workforce (i.e. medical, surgical, radiation oncology etc.) identifies as an underrepresented minority (URM), which has implications for racial bias, discrimination, and cultural compentency.  The scientific premise of this proposal is based on the integration of spatial transcriptomics and artificial intelligence (AI) pathomics to conduct a differential expression analysis between Black and White patients with HPV-negative OPC. We have previous experience using these approaches as a basis to understand gene expression changes between Black and White patients with HPV-positive OPC, which is a distinct neoplastic entity when compared to HPV-negative OPC. Therefore, we will identify differences in gene expression and stromal and immune cell topology between Black and White patients to identify biologic mechanism(s) that underlies racial disparities with respect to oncologic outcomes. Moreover, within this research proposal, in partnership with minority serving schools, we will create two pathways to address the disparity in the oncology workforce, including translational research. We will address these gaps in the field by pursuing the following specific aims: In Aim 1, we will determine spatial gene expression differences Black vs. White patients with HPV-negative OPC. In Aim 2, we will integrate spatial genomics and AI-guided pathomics between high vs. low pathomic expression within tissue types, controlling for self-reported race. To address the gap in URM in the oncology workforce, in Aim 3 we will work in partnership with City of Medicine Academy and Howard University to provide a longitudinal oncology research experience for high school students and surgical residents. In Aim 4, we will provide a laboratory incubator space in which URM Duke Faculty will be embedded to pursue cancer research, along with mentoring from experienced and committed mentors.  We propose to address these important issues and lack of reliable biomarkers for all patients by integrating state-of-the-art techniques in genomics, pathomics, and AI, in a setting fostering diversity and inclusion. The data generated will be of benefit to all patients with HPV- negative OPCs as we are presently unable to identify poor responders regardless of race.

PI_NAMEs: WATTS, TAMMARA L. (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Academy;Address;Agreement;anti-cancer research;Appearance;Artificial Intelligence;Asian;Behavior;Biological;Biological Factors;Biological Markers;black patient;Black race;Cancer Biology;cancer health disparity;Cancer Relapse;career;Caring;Cells;chemoradiation;Cities;college;County;Data;Development;diagnostic strategy;differential expression;Discrimination;Disease;Disparate;Disparity;diversity and inclusion;Elements;Environment;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Fostering;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genomics;Genotype;Head and Neck Cancer;Health;Health system;high school;High School Student;Hispanic;HPV negative;HPV oropharyngeal cancer;Immune;improved;Incubators;innovation;Laboratories;Latino;Latinx;Malignant Neoplasms;malignant oropharynx neoplasm;marginalized community;Medical;medical schools;Medicine;Mentors;Minority;Minority-Serving Institution;Molecular;Monitor;mortality;mortality risk;neoplastic;new technology;next generation;novel diagnostics;Oncology;Operative Surgical Procedures;Oropharyngeal Squamous Cell Carcinoma;Outcome;Pathogenesis;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Prediction of Response to Therapy;programs;Quality of Care;Race;racial bias;racial disparity;Radiation Oncology;radiation resistance;Recording of previous events;Recurrence;Reporting;Research;Research Proposals;Resolution;response;risk stratification;Schools;Science;social;Social Controls;socioeconomics;spatial integration;Stromal Cells;Surveys;survival disparity;Techniques;Tissue-Specific Gene Expression;Tissues;Training;transcriptomic profiling;transcriptomics;Translational Research;treatment effect;Treatment Failure;treatment response;Underrepresented Minority;Universities;Woman;Work

PROJECT_TITLE: Disparate Survival,  Disparate Workforce: An Integrated  Approach to Improving  Head and Neck Cancer Outcomes and Diversity in the Oncology Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Medically complex older Veterans are at greater risk for progressive declines in physical function, lower quality of life, and increasing care needs. Additionally, older Veterans experience social isolation and loneliness, and have low levels of physical activity. While the Veterans Health Administration has established programs to address rehabilitation needs, these programs tend to be diagnosis-focused, lack self-management approaches, include low-intensity rehabilitation, and typically require in-person attendance. A MultiComponent TeleRehabilitation (MCTR) program that includes high-intensity rehabilitation and self-management interventions, social support, and telehealth and technology supports may be more effective in improving and sustaining physical function for older Veterans with complex health conditions. Therefore, this project is designed to determine whether the MCTR program improves strength and physical function more effectively than traditional interventions.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROJECT_TERMS: 2 arm randomized control trial;Acceleration;Achievement;actigraphy;acute symptom;Address;Adverse event;adverse outcome;arm;behavior change;beneficiary;biobehavior;biopsychosocial;Cardiac;Caring;Cessation of life;Chronic;Clinical;Clinical Trials;comparison control;Complex;computer generated;Control Groups;Cross-Over Studies;design;Diagnosis;Disease;Dose;Educational Status;effectiveness evaluation;Emergency department visit;Enrollment;Event;Exercise;exercise intensity;experience;falls;functional decline;Geography;Goals;Health;Health Benefit;health care availability;Health Status;Healthcare;Healthcare Systems;Home;Hospitalization;Impairment;improved;innovation;Intervention;Loneliness;Measures;Medical;Modeling;Motivation;multiple chronic conditions;novel;Outcome;outpatient programs;Participant;patient population;Patient Self-Report;Persons;Phase;Phase Transition;Physical activity;Physical Function;physical inactivity;Physical therapy;Physiological;Population;premature;preservation;primary endpoint;primary outcome;programs;Psyche structure;Publishing;Quality of life;Randomized;randomized trial;rehabilitation management;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Design;Risk;Rural;rural area;rurality;Safety;satisfaction;Self Management;service delivery;Services;sex;skills;social;Social isolation;Social support;standard care;Step Tests;Stroke;Technology;telehealth;telerehabilitation;Testing;theories;Therapeutic Intervention;Transportation;Underserved Population;Update;urban area;Veterans;Veterans Health Administration;whole health

PROJECT_TITLE: Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of ComplexHealth Conditions

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Disease;Orphan Drug;Rare Diseases;Skin Cancer

PHR: Project Narrative No rational therapies have been approved for patients with metastatic acral melanoma, the most common melanoma subtype in populations of color (e.g., Hispanic-, African-, Asian-descent). We have developed approaches to define actionable vulnerabilities in the metastasis and therapy resistance driver landscape.

PI_NAMEs: REBECCA, VITO WILLIAM (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: Ablation;Acral Lentiginous Malignant Melanoma;Address;African;Anabolism;Architecture;arm;Asian ancestry;Autophagocytosis;Biological;Biological Models;Biomechanics;BRAF gene;Breast;cancer cell;Catabolism;cathepsin K;CDK4 gene;Cells;Clinical;Clinical Trials;Collagen;Colorectal Cancer;combat;Computational Biology;Cutaneous Melanoma;Data;Dermal;Dermatology;design;Disease;Drug Tolerance;Engineering;Environment;Enzymes;Exhibits;Fibroblasts;foot;Frequencies;Genes;genetic signature;Genetic Transcription;Hispanic;Human;Hydrogels;immune checkpoint blockade;Implant;In Vitro;in vivo;in vivo Model;individualized medicine;inhibitor;inhibitor therapy;Invaded;Liver;liver ablation;Luciferases;Lysosomes;Malignant Neoplasms;matrix Gla protein;Mechanics;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Memory;memory retention;Metabolic;Metabolism;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Modeling;Molecular;Motility;mouse model;multidisciplinary;Mus;Mutation;Neoplasm Metastasis;NGFR gene;novel strategies;novel therapeutic intervention;novel therapeutics;Organ;Organoids;Outcome;Pancreas;Pathway interactions;patient derived xenograft model;Patients;people of color;Phenotype;pre-clinical;programs;Property;protein biomarkers;Proteins;PTK2 gene;Publishing;rational design;Reporter;Research;Resistance;Resources;single-cell RNA sequencing;Site;Skin;Survival Rate;Testing;Therapeutic;therapy resistant;Tissues;Traction;transcriptome sequencing;Tropism;tumor;tumor progression;tumorigenic;viscoelasticity;Western Blotting

PROJECT_TITLE: Effect of the plantar skin microenvironment on tumor metastasis and drug tolerance

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Nutrition;Pediatric;Precision Medicine;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We propose to create a first-of-its-kind Mother-infant Metabolite-transporter Atlas (MiMA) by generating and integrating information on structure, function, and localization of novel transporter-metabolite pairs that allow maternal infant communication through the mother’s milk→infant gut→infant’s blood-brain-barrier. Although MiMA will generate these insights in the context of mother-infant milk-gut-BBB axis, systems level integration of information is expected to enable the extraction of actionable insights into which metabolites bind to which transporters, to get transported from where to where in diverse contexts, both health and disease. These insights are expected to spur the development of new strategies in precision nutrition and precision medicine relevant for mother and child and in multiple disease domains beyond infant well-being.

PI_NAMEs: CHANG, GEOFFREY A (contact);GHOSH, PRADIPTA ;STOWELL, MICHAEL H. B.;SUHANDYNATA, RAYMOND THEODORE

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: Affect;anti-depressive agents;Atlases;Binding;Bioinformatics;Biological Assay;Biological Models;Biology;biophysical techniques;Blood;Blood - brain barrier anatomy;Breast;Cells;Chemicals;Child;Child Development;Classification;Communication;Communities;Compensation;Complex;Data;Development;dietary supplements;Disease;drug of abuse;Drug or chemical Tissue Distribution;Ensure;experimental study;fetal;fetal blood;Food;Genome;genome wide association study;gut-brain axis;Health;Homeostasis;Human;human disease;Human Milk;Immobilization;Individual;Infant;Infrastructure;innovation;insight;intimate behavior;knock-down;Knowledge;Lactation;Ligands;Link;Liquid substance;Literature;Mammary gland;Maps;Maternal Behavior;Measurement;Measures;medication safety;Membrane;Metabolite Interaction;metabolome;metabolomics;Milk;Modeling;Molecular;Molecular Structure;monolayer;Mothers;Movement;multiple omics;nanobodies;Nomenclature;novel;Nursing infant;nursing mothers;Nutrient;Opioid;Organ;Organoids;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Physiology;Placenta;Plasma;postnatal period;precision medicine;precision nutrition;Pregnancy;pregnant;Process;Proteins;Proteomics;Reagent;Recreation;Research;Resources;Role;Sampling;small molecule;Specificity;Standardization;structural biology;Structure;Surface Plasmon Resonance;synergism;System;Systems Integration;Tissues;Update;uptake;Validation;Variant;Xenobiotics

PROJECT_TITLE: MiMA: Mother-infant Metabolite-transporter Atlas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]