NIH_SPENDING_CATS: Chronic Pain;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioids;Pain Research

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative The University of Washington's (UW) Division of Pain Medicine (UW Pain) is well poised to become a Specialized Clinical Center within the HEAL Initiative's Early Phase Pain Investigation Clinical Network. Its breadth and depth of pain expertise, functional infrastructure, accessible resources, established UW affiliated networks and inter-state collaborations that provide access to geographically and demographically diverse patient populations, and a broad range of medical and surgical disorders for which pain is a clinically significant component provide support for UW Pain as a highly effective Specialized Clinical Center. The UW EPPIC-Net Hub and Spokes infrastructure will provide scientific leadership and administrative oversight of high-quality multidisciplinary Phase 2 clinical trials and biomarker validation studies, develop policies and procedures for rapid design, initiation, recruitment, conduct, and closure of these studies throughout the hub-spoke network, and establish mechanisms for communication, education and training, and performance assessment to assure efficient and timely utilization of resources.

PI_NAMEs: CURATOLO, MICHELE ;PATEL, KUSHANG  (contact);STACEY, BRETT

PROJECT_TERMS: Academic Medical Centers;Affect;Alaska;Ambulatory Care;Analgesics;Behavioral;Bioethics;Biological Markers;biomarker validation;biopsychosocial;cancer care;Caring;Childhood;Clinic;Clinical;Clinical and Translational Science Awards;clinical biomarkers;clinical center;clinical investigation;Clinical Research;clinical research site;Clinical Trials;clinically significant;Collaborations;Communication;Conduct Clinical Trials;Consultations;Data;design;Development;Dimensions;Disease;Elderly;Epidemic;experience;Family Practice;flexibility;Geography;Goals;Health;Health system;Helping to End Addiction Long-term;Idaho;Illinois;Infrastructure;innovation;Inpatients;Laboratories;Leadership;Medical;Medical center;medical specialties;Medicine;Military Personnel;Monitor;Montana;Multi-Institutional Clinical Trial;multidisciplinary;neuroimaging;Operative Surgical Procedures;opioid epidemic;opioid misuse;Oregon;Outpatients;overdose death;Pacific Northwest;Pain;Pain Clinics;Pain Disorder;Pain management;Participant;participant enrollment;patient population;Patients;Pediatric Hospitals;Performance;Phase;Phase II Clinical Trials;phase II trial;Phenotype;Policies;Population;primary care clinic;Principal Investigator;Procedures;psychologic;Public Health;quality assurance;Recording of previous events;recruit;Research;Research Personnel;Research Support;Resources;response;Rural Population;Safety;Science;Scientist;Seasons;Sensory;Site;skills;Testing;Training;Training and Education;translational health science;Translational Research;Underserved Population;Universities;validation studies;Washington;Work;Writing;Wyoming

PROJECT_TITLE: EPPIC-Net Hub at University of Washington


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: The University of Pittsburgh Hub and Spoke Clinical Trial Network is composed of a team of multidisciplinary experts in the field of Pain Medicine with extensive experience conducting pain clinical trials. In this proposal will describe how we are well-suited to perform multisite clinical trials and poised to train junior pain clinical trial investigators.

PI_NAMEs: ALTER, BENEDICT J;WASAN, AJAY D (contact)

PROGRAM_OFFICER_NAME: BARNES, JENNIFER HAMILTON

PROJECT_TERMS: Abdominal Pain;Address;Advisory Committees;Anesthesiology;Animals;Area;Articulation;Biological Markers;Biometry;California;cancer pain;career;Childhood;Clinic;Clinical;clinical center;Clinical Investigator;clinical pain;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Collection;Data;Decentralization;design;Discipline of obstetrics;Ensure;Environment;experience;flexibility;Funding;Genomics;Grant;Guidelines;Gynecologic;HIV;Hospitals;Human;improved;Individual;innovation;Institution;Intervention;Intervention Trial;Laboratories;Lead;Leadership;Longevity;Medical center;Medical Informatics;medical specialties;Medicine;Mentors;mind/body;Multi-Institutional Clinical Trial;multidisciplinary;Nerve Block;Neurology;next generation;non-opioid analgesic;novel strategies;organizational structure;Orthopedics;Pain;Pain Clinics;Pain management;Pain Research;Peer Review;Performance;personalized approach;Phenotype;Physical Medicine;Positioning Attribute;Productivity;Professional Organizations;Protocols documentation;Psychiatry;psychologic;Psychology;Publications;Publishing;Recording of previous events;Rehabilitation therapy;Reporting;Reproducibility;Research;Research Design;Research Personnel;research study;Resources;Role;Rural;Science;Sickle Cell Anemia;Site;Structure;Training;Translations;Universities;Washington;Wisconsin;Woman;Work

PROJECT_TITLE: University of Pittsburgh Hub and Spoke Pain Clinical Trial Network


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Neurosciences;Pain Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative This proposal aims to outline the development of a Hub-spoke complex, The California Clinical and Translational Pain Research Consortium (CCTPRC) consisting of four University of California Universities. These centers have considerable experience in pain management clinical trials, phenotyping and biomarker validation, and integrative health initiatives. The Hub will be located at the University of California San Diego.

PI_NAMEs: WALLACE, MARK S (contact)

PROJECT_TERMS: Academic Medical Centers;Acupuncture Therapy;Address;American;Analgesics;Biological;Biological Markers;biomarker identification;biomarker validation;Brain imaging;California;Cannabis;Centers for Disease Control and Prevention (U.S.);chronic pain;chronic pain management;Classification;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Data;Clinical Research;Clinical Trials;Cognitive;Collaborations;Complex;Conduct Clinical Trials;Data;Data Analyses;Data Collection;data integrity;data management;design;Development;effective therapy;evidence base;experience;Financial Hardship;flexibility;Foundations;Genetic;Goals;Guidelines;Health;informatics infrastructure;Infrastructure;innovation;insight;Insurance Carriers;Integrative Medicine;interdisciplinary approach;Intervention;Knowledge;Leadership;life span;Medicine;mental training;Methods;mind/body;mindfulness;Multi-Institutional Clinical Trial;multidisciplinary;multimodality;Natural Products;Nature;novel;novel therapeutics;opioid epidemic;Outcome;Outcome Measure;Pain;Pain management;pain outcome;Pain Research;Patients;Persons;Phase II Clinical Trials;phase II trial;Phenotype;Physiological;Population;Process;psychologic;Publishing;Recommendation;recruit;Reproducibility;Research;Research Institute;Resources;San Francisco;Scientist;Secure;Site;Solid;Standardization;statistics;support tools;Testing;Therapeutic;Translational Research;United States;Universities;validation studies;Work;Yoga


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE We plan to complete this long-running program by completion of experiments already in progress. We will also arrange for preservation of animal models and other resources generated by this program.

PI_NAMEs: MEISLER, MIRIAM H (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: ALS patients;Anabolism;Animal Model;bone;Cardiac;causal variant;Cell Culture Techniques;comorbidity;Compensation;Complementary DNA;Cytoplasm;Defect;Development;Disease;druggable target;Embryo;Evaluation;Exhibits;experimental study;Fibroblasts;Funding;gene interaction;gene therapy;Genes;Genetic;Genetic Diseases;Genetic Research;genome wide screen;Goals;Human;Human Genetics;human model;immune function;Impairment;in vivo;Intervention;Ion Channel;Ion Transport;Ions;Knockout Mice;Lipids;LoxP-flanked allele;Lysosomal Storage Diseases;lysosome membrane;Lysosomes;Macrophage;Maintenance;Molecular;Monitor;mouse model;Mus;Mutant Strains Mice;Mutation;Nervous System Disorder;Neurologic;novel;Osmolar Concentration;overexpression;Paper;Pathogenicity;Patients;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;preservation;programs;Publications;Publishing;Reagent;Recurrence;Regulation;Research;Resources;Role;Running;Signal Transduction;skeletal;symporter;System;therapeutic effectiveness;therapeutic evaluation;Therapeutic Intervention;therapy development;Transgenes;Up-Regulation;Variant;Work

PROJECT_TITLE: Gene Interaction in Development and Disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCGILL UNIVERSITY

ORG_STATE: QC

ORG_ZIPCODE: H3A 0G4

PHR: Project Narrative (Spreng/Bzdok, McGill University) ! PROJECT NARRATIVE Loneliness in older adulthood is associated with cognitive decline and more rapid onset of Alzheimer's disease (AD), increasing burdens on the individual, caregivers, and the healthcare system. How loneliness impacts brain structure and function in later life, and whether it precedes or promotes accelerated neurodegeneration and the emergence of AD, is unknown. The proposed research will investigate how loneliness, a modifiable risk factor for AD, impacts the brain in normal aging and pre-symptomatic AD, towards the longer term goal of better surveillance and intervention. ! !1

PI_NAMEs: BZDOK, DANILO ;SPRENG, ROBERT NATHAN  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Address;Adopted;Age;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Behavioral;behavioral response;biobank;Brain;Brain Diseases;brain health;Caregivers;Cognitive;cognitive ability;Cognitive aging;cohort;Collaborations;Collection;Data;Data Collection;Data Set;Death Rate;Dementia;dementia risk;demographics;Detection;Disease;Disease Progression;Elderly;Epidemic;Evaluation;experience;Feeling;Goals;Healthcare Systems;human old age (65+);Impaired cognition;Individual;innovation;insight;Intervention;Laboratories;late life;Learning;Link;Loneliness;lonely individuals;Longitudinal cohort;Longitudinal Studies;Measurement;Methods;Modeling;modifiable risk;Monitor;Nature;Nerve Degeneration;neural;Neurobiology;neuroimaging;neuromechanism;neuropathology;Neurosciences;normal aging;novel;older adult;Older Population;Outcome;Participant;Pattern;Phenotype;Policies;poor health outcome;Population;pre-clinical;psychologic;Public Health;public health priorities;Reporting;Research;Research Design;Resolution;response;retiree;Risk;Role;Sample Size;Sampling;Scheme;Series;Shapes;Signal Transduction;social;Social Conditions;Social isolation;Structure;System;Testing;Universities;Work;World Health Organization;young adult

PROJECT_TITLE: Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progression

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Tuberculosis (TB) preventive therapy and treatment for active disease are long in duration, and for people living with HIV, TB preventive therapy can last for years. The use of long-acting injectable (LAI) drug formulations for TB prevention and treatment could significantly ease the burdens associated with such long-term daily pill intake, both for individual patients and for public health systems. The aim of this project is to develop novel LAI formu- lations for TB prevention and treatment comprised of next-generation diarylquinolines with potent anti-TB activity and physiochemical properties highly amenable to LAI formulation.

PI_NAMEs: NUERMBERGER, ERIC L (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: active method;Antitubercular Agents;bactericide;candidate selection;Cause of Death;Cessation of life;Chemistry;Collaborations;Companions;comparative efficacy;Data;design;Development;Disease;Dose;Drug Formulations;Drug Kinetics;Drug resistance in tuberculosis;efficacy study;efficacy testing;Evaluation;Failure;follow-up;Formulation;Goals;Good Manufacturing Process;Health system;HIV;In Vitro;in vivo;individual patient;Injectable;Injections;Intake;Investigational Drugs;Investigational New Drug Application;isoniazid;Kinetics;Libraries;manufacture;member;Modeling;mouse model;Mus;Mycobacterium tuberculosis;nanoengineering;nanoparticle drug;next generation;novel;Oral;Oral Administration;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Phase;phase I trial;Physiological;pill;Plasma;premature;prevent;Prevention;Prevention strategy;Preventive therapy;Preventive treatment;Property;Public Health;Rationalization;Recommendation;Regimen;Relapse;Research;Rifabutin;Rifampin;Rifamycins;rifapentine;Safety;scale up;Series;Site;Solid;Techniques;technology platform;Testing;Therapeutic;Treatment Efficacy;treatment strategy;Tuberculosis;tuberculosis treatment;Universities;Work;World Health Organization

PROJECT_TITLE: Harnessing potent next-generation diarylquinolines for long-acting injectable formulations to prevent and treat tuberculosis


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: FAIRFAX

ORG_NAME: VIGNET, INC.

ORG_STATE: VA

PI_NAMEs: BEGALE, MARK ;JAIN, NEETA ;JAIN, PRADUMAN  (contact);SUTHERLAND, SCOTT ANDREW

PROGRAM_OFFICER_NAME: MCCLAIN, JAMES J

PROJECT_TITLE: PTSC 2.0

SUFFIX: SG


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Addressing the End the HIV Epidemic initiatives, this study will use innovative electronic methods (e.g., social media with community informed advertisements) to recruit and retain a large (N=5,000), diverse national sample of high-risk young men who have sex with men (YMSM) 17-25 years of age to better understand correlates of HIV-related sexual risk and HIV incidence within the context of a theoretically-grounded social- ecological framework. In addition to the epidemiologic aim of the proposed research, we will test the efficacy of MyPEEPS Mobile, a promising mHealth HIV prevention intervention in reducing HIV incidence among YMSM.

PI_NAMEs: DUNCAN, DUSTIN T;GAROFALO, ROBERT ;SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MANDT, REBECCA ELIZABETH KILIAN

PROJECT_TERMS: 18 year old;Accounting;Address;Advertisements;Advertising;Affect;Age;Age Years;AIDS prevention;Alcohol consumption;Anxiety;arm;Behavior;behavior change;Behavioral Model;Bisexual;Black race;cisgender;Clinical Trials;cohort;Communities;condomless anal sex;Crime;Data;digital;digital delivery;Discrimination;efficacy evaluation;efficacy testing;efficacy trial;Electronics;Enrollment;Epidemic;Epidemiology;epidemiology study;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Exclusion;experience;Facebook;Frequencies;Funding;Future;Gays;Geographic Locations;health care service;health seeking behavior;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Hot Spot;Incidence;Individual;Individual Differences;innovation;innovative technologies;Instagram;Institution;Intervention;intervention effect;Intervention Studies;intimate partner violence;Knowledge;Latino;Literature;longitudinal analysis;male;Measures;Mediator;men who have sex with men;Mental Depression;Methods;mHealth;Modeling;Motivation;Neighborhoods;observational cohort study;Outcome;Participant;peer;Persons;Phase;Policies;Population;Positioning Attribute;Poverty;pre-exposure prophylaxis;Predisposition;Prevalence;Prevention Research;preventive intervention;Principal Investigator;Public Policy;Race;racial diversity;racial minority;Randomized;Recording of previous events;recruit;Reporting;Research;Research Design;Research Personnel;research study;response;retention rate;Risk;Rural;same-sex partnership;Sample Size;Sampling;Science;Self Efficacy;seroconversion;sexual minority;sexual risk behavior;sexual risk reduction;social;social media;social stigma;Social support;standard of care;substance use;success;Techniques;Testing;theories;therapy development;TikTok;Time;transmission process;Treatment Efficacy;tribal lands;Twitter;United States;United States National Institutes of Health;Unsafe Sex;uptake;virtual;young men who have sex with men

PROJECT_TITLE: MyPEEPS Mobile LITE:  Limited Interaction Efficacy Trial of MyPEEPS Mobile to Reduce HIV Incidence and Better Understand the Epidemiology of HIV among YMSM


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research project has high relevance to public health because it focuses on sexual and gender minority (SGM) youth, particularly Black and Latinx, gay, bisexual and other men who have sex with men (GBMSM) and transgender and gender diverse populations that have been devastated by the HIV epidemic in the United States. This study supports the National HIV/AIDS Strategy’s focus on HIV treatment and prevention for the most impacted US populations. The development of a large, digital community of SGM youth also aligns with the NIH’s focus on reducing stigma and addressing co-morbidities and barriers to adherence and retention in HIV care and preventative services.

PI_NAMEs: FRENCH, AUDREY ;HIGHTOW-WEIDMAN, LISA B;HOSEK, SYBIL  (contact)

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;Age;AIDS prevention;Area;Articulation;Award;Behavior;Biological;Bisexual;Black race;care systems;Caring;Clinic;clinical research site;Clinical Trials;Cognitive;cohort;Cohort Studies;Communities;comorbidity;cost;design;Development;Devices;Diagnostic;digital;digital health;Discrimination;efficacy evaluation;efficacy testing;Electronics;Enrollment;Epidemic;epidemiological model;Epidemiology;ethnic minority;Exclusion;experience;Friends;Gays;gender diverse;gender minority;gender minority youth;Geography;health inequalities;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;HIV/STD;Human Resources;improved;Incidence;Individual;infection rate;infection risk;Injectable;innovation;interest;Intervention;Latinx;Longitudinal cohort;Longitudinal cohort study;Medical;men who have sex with men;Methodology;mobile application;Monitor;nonbinary;novel;Oral;Participant;Persons;Phase;Population;Population Heterogeneity;pre-exposure prophylaxis;Prevention;Prevention strategy;preventive intervention;Preventive service;Productivity;psychologic;Public Health;Published Comment;racial minority;randomized, clinical trials;Recording of previous events;recruit;Research;Research Project Grants;response;retention rate;Risk;self testing;Sex Behavior;Sexual and Gender Minorities;sexual minority;sexual minority community;sexual minority youth;sexually active;Site;Social Change;social stigma;Structural Racism;Technology;Testing;Time;tool;transfeminine;transgender;transmasculine;transmission process;United States;United States National Institutes of Health;uptake;Viral;Vulnerable Populations;Youth

PROJECT_TITLE: Keeping it LITE 2: Exploring HIV Risk in Vulnerable Youth with Limited Interaction and Digital Health Intervention (LITE-2)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PI_NAMEs: KANNAN, KURUNTHACHALAM ;KANNAN, KURUNTHACHALAM  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TITLE: Targeted Analysis


PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Lung;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative Although a large proportion of individuals living in rural Appalachia and the Mississippi Delta (AMD) experience strikingly high rates of heart and lung disease (hot spots), some other communities in the same region seem to be relatively spared (cold spots). To study this regional variation in disease risk and the potential basis of resilience of `cold spots', we will recruit and study 4000 young-to-middle aged men and women from different race/ethnicity groups living in six high risk and four lower risk poor rural counties in four Southern states. We will reach these communities using a mobile van, and measure levels of both protective and harmful influences in the people and their neighborhoods, hoping to understand what causes the high burden of heart and lung disease in these rural Southern regions and how to improve and prevent it.

PI_NAMEs: JUDD, SUZANNE E;RAMACHANDRAN, VASAN S (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acceleration;adjudication;Affect;Age;Alabama;allostatic load;Ankle;Appalachian Region;Behavioral;biobank;Biological Assay;Biological Process;Black Populations;Blood;Buffers;burden of illness;Cellular Phone;Clinic;Clinical;cohort;Cohort Studies;Communities;Community Health;Complex;coronary artery calcium;County;Data;data harmonization;data repository;Death Rate;Development;Diabetes Mellitus;digital technology;Disease;disorder risk;Disparity population;early onset;Economic Factors;Economics;Environment;Environmental Risk Factor;Epidemic;Ethnic Origin;Ethnic Population;Etiology;Event;experience;Frequencies;Future;Generations;Genetic Predisposition to Disease;Genetic Risk;Glucose;Health;health disparity populations;Health education;Health Personnel;Health Technology;Heart;Heart Diseases;Heart Rate;Hematological Disease;high risk;Hispanic;Home;Hot Spot;Hour;Hypertension;Imaging technology;implementation science;improved;Incidence;indexing;Individual;Individual Differences;innovation;Kentucky;Kidney Diseases;Knowledge;Learning;Life Cycle Stages;Life Style;lifestyle factors;Longitudinal cohort study;Longitudinal Studies;Louisiana;Lung;Lung Diseases;male;Malignant Neoplasms;Measures;Mediation;Medical History;Medical Records;men;mHealth;middle age;Minority Status;Mississippi;mobile computing;Modernization;Modification;Monitor;Morbidity - disease rate;mortality;multi-ethnic;Neighborhoods;novel;Obesity;Oral;Participant;Patient Recruitments;Patient Self-Report;Pattern;Persons;Physiologic pulse;Physiological;polygenic risk score;Population Sizes;Postural adjustments;Poverty;premature;Prevalence;prevent;Prognosis;progression risk;prospective;Psychosocial Factor;psychosocial wellbeing;Public Health;Publishing;pulmonary function;Race;racial population;recruit;residence;resilience;resilience factor;response;Risk;Risk Factors;Rural;Rural Appalachia;rural area;Rural Community;rural counties;Rural Health;rural setting;rurality;Sampling;Scientist;sex;Sleep;Sleep Disorders;social;social factors;Spirometry;Spottings;syndemic;Testing;Time;tool;trait;Translating;United States;urban area;Variant;Walking;wearable device;Woman;X-Ray Computed Tomography

PROJECT_TITLE: RURAL: Risk Underlying Rural Areas Longitudinal Cohort Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Lipoproteins are essential particles that transport fats to different cells in the brain. In individuals with Alzheimer's disease (AD), lipoproteins are not taken up by cells properly and instead bind to other factors outside the cell such as amyloid, leading to amyloid plaque formation, and damage to brain tissue and function. In this proposal, we aim to enhance the activity of the enzyme lipoprotein lipase (LPL), which can help specialized cells called microglia remove excess lipoproteins, prevent amyloid accumulation, and protect against the development of AD.

PI_NAMEs: BRUCE, KIMBERLEY D (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's neuropathogenesis;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Binding;Biology;Brain;brain tissue;Cells;Clinical;Data;Development;Disease Progression;Disease susceptibility;effective therapy;enzyme activity;Enzymes;epidemiology study;Fatty acid glycerol esters;Functional disorder;gain of function;Gatekeeping;Human;Hydrolysis;immune function;improved;in vivo;Individual;knock-down;Laboratories;Left;lipid metabolism;lipid transport;Lipids;lipoprotein lipase;lipoprotein lipase activators;Lipoproteins;metabolic imaging;Metabolism;Microglia;Mus;Neurodegenerative Disorders;novel;Onset of illness;particle;Phagocytes;Phagocytosis;pharmacologic;Play;Positioning Attribute;Prevalence;prevent;Protein Isoforms;Role;Scaffolding Protein;Senile Plaques;Testing;therapeutic target;uptake;Variant

PROJECT_TITLE: Targeting Microglial Lipoprotein Lipase in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Sleep Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Untreated insomnia symptoms in community-dwelling persons with Alzheimer’s Disease and related Dementias contribute to increased institutionalization and accelerated disease progression. Because of the adverse side effects associated with drug treatment, effective, low-cost, easily adaptable in-home interventions are needed to improve insomnia symptoms in persons with Alzheimer’s Disease and related Dementias. Examining the effects of a tailored music-based mobile application aimed at improving insomnia symptoms in this population will inform future efficacy trials, potentially increasing the number of evidence-based options for non-pharmacologic approaches.

PI_NAMEs: PETROVSKY, DARINA V. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acceleration;actigraphy;Address;Alzheimer's disease related dementia;Area;Behavior Therapy;Behavioral Model;Behavioral Research;Behavioral Symptoms;career;Caregiver Burden;Caregivers;Caucasians;Clinical Trials;cognitive function;Cognitive Therapy;Communities;community based participatory research;Control Groups;cost;Data;Data Collection;Dementia;design;diaries;Disease;Disease Progression;Education;Educational workshop;efficacy evaluation;efficacy trial;evidence base;experience;fall risk;Focus Groups;Funding;Future;Goals;high risk;Home;implementation facilitation;improved;improvement on sleep;Institutionalization;Intervention;intervention delivery;intervention effect;intervention refinement;Intervention Studies;Interview;Knowledge;Link;long term memory;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;mobile application;Music;Music Therapy;Nonpharmacologic Therapy;novel;older adult;Outcome;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Pharmacological Treatment;Pharmacotherapy;Pilot Projects;poor health outcome;Population;post intervention;preservation;programs;Property;prototype;Proxy;Quality of life;Randomized;Relaxation;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Risk;satisfaction;Sedation procedure;side effect;skills;Sleep;sleep onset;sleep quality;Sleeplessness;Surveys;Symptoms;Technology;Testing;therapy development;Time;Training;Training Activity;Treatment Efficacy;Underrepresented Populations;United States National Institutes of Health;user centered design;user-friendly

PROJECT_TITLE: Music-based Intervention for Insomnia in Persons Living with Dementia and their Caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Infectious Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE HIV-related mortality has decreased in individuals treated with antiretroviral therapy, however older adults with HIV (OAH) experience more co-morbidities than their HIV negative peers, and inflammatory changes with aging remain incompletely understood. New biomarkers are needed to identify OAH at higher risk of geriatric syndromes, and recent advances in understanding of cellular death processes, including necrosis-mediated cell death, have allowed for measurement of cell-free mitochondrial DNA (cfmtDNA) as a novel biomarker. The goals of this proposal are to investigate cfmtDNA in plasma and urine as a biomarker of geriatric syndromes in a longitudinal study of OAH, evaluate the immunostimulatory potential of cfmtDNA, and foster the career development of a physician-scientist who has, and will continue to, dedicate her career to HIV research.

PI_NAMEs: JOHNSTON, CARRIE DOWN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Administrative Supplement;Advisory Committees;Age;Aging;aging related;Anti-Retroviral Agents;antiretroviral therapy;Back;biobank;Biological Markers;Biostatistical Methods;Blood;Body Weight decreased;career;career development;Caring;Cell Death;Cells;Cessation of life;Chronic;Clinical;clinical care;clinical investigation;Coculture Techniques;Cognition;cognitive function;cognitive performance;cognitive testing;cohort;comorbidity;Data;Dedications;DNA;Elderly;Epidemic;Eugenia;Evaluation;experience;experimental study;falls;forging;Fostering;Foundations;frailty;Functional disorder;Gene Activation;Geriatrics;Goals;high risk;HIV;HIV Infections;HIV Seronegativity;Immune;immune activation;Immunologic Stimulation;Immunology;Impaired cognition;improved;In Vitro;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Institution;instrumental activity of daily living;Interferons;Intervention;Investigation;Link;Longitudinal Studies;Master of Science;Measurement;Measures;Mediating;Mediator;Medical;Mentors;Mentorship;Mitochondrial DNA;Molecular;Morbidity - disease rate;mortality;Natural Immunity;Necrosis;Nested Case-Control Study;Neurocognitive;Neuropsychology;novel marker;older adult;Participant;Pattern;peer;Performance;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Physicians;Plasma;Plasma Cells;Ploidies;pro-aging;Process;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk;Role;sample collection;Scientist;skills;Stress;success;Syndrome;Testing;Time;tool;Training;Training Programs;transcriptome sequencing;Translational Research;translational study;urinary;Urine;Viremia;Visit

PROJECT_TITLE: Aging with HIV: Novel Biomarkers of Inflammation and Morbidity - Administrative Supplement

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Neurons in the mammalian hindbrain innervate the heart through the vagus nerve to control resting and reflexive heart rate. Recent research has found such neurons in the dorsal motor nucleus of the vagus. Identifying these neurons molecularly and functionally could lead to a novel therapeutic target for treating heart disease.

PI_NAMEs: CAMPBELL, JOHN N (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Autonomic nervous system;Axon;Cardiac;Circulation;Cranial Nerves;dorsal motor nucleus;Ganglia;Gene Expression;Health;Heart;Heart Diseases;heart function;Heart Rate;hindbrain;Home;immune function;Learning;Mediating;Metabolic;Minority;Molecular;molecular subtypes;Nature;neural circuit;Neurons;new therapeutic target;Physiological;Research;response;Rest;Role;Taxonomy;Vagus nerve structure

PROJECT_TITLE: Molecular and Functional Taxonomy of Cardiovagal Neurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Vascular smooth muscle cell (VSMC) phenotypic modulation, a phenotypic switch from a differentiated contractile phenotype to a proliferative phenotype, contributes to vascular remodeling and the development of diverse vascular diseases such as atherosclerosis, hypertension, and restenosis following angioplasty. We have uncovered a novel role of Runt-related transcription factor 3 (RUNX3) in VSMC phenotypic modulation and proliferation, implicating it in the development of vascular injury-related cardiovascular diseases. The proposed studies will shed new lights on the pathogenesis of neointima formation and vascular remodeling, which may ultimately lead to the identification of novel targets for the therapeutic treatment of cardiovascular diseases related to vascular remodeling.

PI_NAMEs: GUO, XIA  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;Angioplasty;Atherosclerosis;beta catenin;Blood Vessels;c-myc Genes;C57BL/6 Mouse;Cardiovascular Diseases;Carotid Arteries;Carotid Artery Injuries;Cell Proliferation;Common carotid artery;Data;Development;Endothelial Cells;Family;Gene Expression;Genetic Markers;glycogen synthase kinase 3 beta;Hypertension;In Vitro;in vivo;Injury;knock-down;Knockout Mice;Left;Ligation;Mediating;Molecular;myocardin;neointima formation;new therapeutic target;novel;overexpression;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;platelet-derived growth factor BB;Play;Proliferating;promoter;Regulator Genes;restenosis;Role;RUNX3 gene;Signal Transduction;Smooth Muscle Myocytes;Testing;transcription factor;Transcriptional Activation;Tunica Intima;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation

PROJECT_TITLE: RUNX3 in Vascular Wall Remodeling-Diversity Supplements


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Dementia with Lewy bodies (DLB) causes a pattern of symptoms that overlaps with symptoms observed in patients with Parkinson’s disease and Alzheimer’s disease. Patient with DLB have accelerated cognitive impairment and psychosis compared to patients with Parkinson’s disease, and at autopsy they frequently have features that are found in the brains of patients with Alzheimer’s disease, including amyloid plaques and neurofibrillary tangles, in addition to the hallmark Lewy bodies that are composed of the protein alpha- synuclein (aSyn). The factors that cause patients with DLB to develop dementia more rapidly than patients with Parkinson’s disease are not completely understood, but the APOE4 variant of the apolipoprotein E gene is strongly associated with risk of DLB, similar to its association with risk of Alzheimer’s disease. We recently reported that human forms of APOE specifically regulate pathological aggregation of aSyn when expressed in mice. We will investigate the relationship between APOE genotype and specific cell types that accumulate aSyn aggregates which are believed to contribute to neurodegeneration in DLB. Specifically, we will examine the impact of APOE genotype on the ability of astrocytes and microglia, two important types of glial cells in the brain, to take up and degrade harmful aSyn aggregates. By better understanding the genetic and cellular changes that link the APOE4 risk gene to pathological aSyn aggregation and neurodegeneration, we should be able to develop novel treatments to slow and prevent DLB, Alzheimer’s disease, and related dementia illnesses.

PI_NAMEs: DAVIS, ALBERT A (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Autopsy;Binding;Biological;Body Composition;Brain;brain dysfunction;Brain region;cell type;Cells;Cessation of life;Clinical;Cost aspects;Data;Dementia;dementia risk;Dementia with Lewy Bodies;Disease;E protein;Endosomes;experimental study;Gene Expression;Genes;Genetic;Genetic study;genetic variant;Genotype;Goals;Human;Impaired cognition;Impairment;Knowledge;Lewy Bodies;Lewy Body Disease;Link;Mediating;Microglia;mouse model;Mus;Nerve Degeneration;Neurofibrillary Tangles;Neuroglia;Neurons;novel;Parkinson Disease;particle;Pathologic;Pathology;Pathway interactions;Patients;Pattern;prevent;Process;Proteins;Psychoses;receptor;Reporting;Risk;risk variant;Role;Senile Plaques;Symptoms;Testing;trafficking;Variant

PROJECT_TITLE: Role of APOE in endosomal processing of alpha-synuclein


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Renal pericytes are the mural cell type associated with capillaries and express the major receptor for angiotensin II, a key vasoactive peptide of the renin-angiotensin system. However, the contributions of angiotensin II signaling in pericytes to regulate blood pressure are unknown. This project will use a novel mouse line with cell- specific deletion of type 1 angiotensin receptors in pericytes to examine the role of angiotensin II signaling in this specialized cell population to drive hypertension and renal injury.

PI_NAMEs: NELSON, JONATHAN W (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Angiotensin II;Angiotensin II Receptor;Angiotensin Receptor;Angiotensins;Animals;Attenuated;Automobile Driving;Bioinformatics;Biology;Biomedical Research;Blood capillaries;Blood flow;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Blood Vessels;career;career development;cell type;Cells;Chronic Kidney Failure;Coal;comparison control;Coupled;Data Set;decubitus ulcer;defined contribution;design;Development;Diameter;Drug Targeting;experimental study;Fluorescence-Activated Cell Sorting;Functional disorder;Gene Targeting;Genetic;Genetic Transcription;Glomerular Filtration Rate;GTP-Binding Proteins;Health;Heart failure;Human;Hypertension;hypertension treatment;Image;in vivo;Infusion procedures;Injury to Kidney;Kidney;Kidney Diseases;kidney vascular structure;knockout animal;Knockout Mice;Knowledge;Link;Measures;Mediating;Mentors;Mentorship;Microsurgery;Molecular;Molecular Biology;Mus;Myofibroblast;Natriuresis;Nephrology;next generation;novel;novel therapeutics;Optics;Oregon;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptides;Pericytes;pharmacologic;Physiology;Play;Population;Population Distributions;Principal Investigator;Process;programs;Publications;Publishing;receptor;Receptor, Angiotensin, Type 1;Renal Blood Flow;Renal function;Renal Hypertension;renin hypertension;Renin-Angiotensin System;Research;Research Personnel;Research Proposals;Resistance;Role;Science;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Slice;Sorting;Systemic blood pressure;Techniques;Testing;Tissues;tool;Training;transcriptional reprogramming;Universities;Vascular Diseases;Vascular Morphologic Change;vasoconstriction

PROJECT_TITLE: Renal Pericytes as a Target for Angiotensin II Signaling in Hypertension

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE The pathophysiological causes for the involuntary and debilitating muscle over - and co-contractions in dystonia are poorly understood, despite it being the third most common movement disorder in the United States. Animal models for dystonia point toward a mechanistic role for the inception of dystonia -like motor deficits stemming from dysfunction of cerebellar nuclei neurons, which connect the cerebellar circuit to other regions in the motor circuit that are also involved in dystonia. I will use quantitative electrophysiology in genetic, pharmacological, and optogenetic mouse models of dystonia to determine if a dystonia-specific signature in the spiking activity of cerebellar nuclei neurons drives the disease and track how this signature arises during aberrant circuit maturation.

PI_NAMEs: VAN DER HEIJDEN, MEIKE ESTHER (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acute;Adult;Affect;Age;Animal Model;Ataxia;Award;Basal Ganglia;Behavior;Biological Markers;Body part;Brain Stem;career;career development;Cell Nucleus;Cell Physiology;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Child;Childhood Onset Dystonias;Clinical;college;computational platform;Databases;Deep Brain Stimulation;Defect;design;Development;Disease;Disease susceptibility;Dystonia;Early Onset Dystonia;effective therapy;Electrophysiology (science);Etiology;experimental study;Fiber;Foundations;Functional disorder;Funding;Genetic;Genetic Heterogeneity;Goals;Heart;Hereditary Dystonia;Human;Impairment;in vivo;insight;Knowledge;Laboratories;Leadership;Medical center;Medicine;Mentors;Mentorship;Modeling;Motion;Motor;motor control;Motor Cortex;motor deficit;motor disorder;motor impairment;mouse genetics;mouse model;Movement;Movement Disorders;Mus;Muscle;Muscle Contraction;mutant;mutation carrier;Nervous System Disorder;neural network classifier;Neuroanatomy;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;Neurologic Deficit;neuron development;Neurons;neurophysiology;Neurosciences;Neurosciences Research;neurotransmission;optogenetics;Output;Pain;Paper;Pathway interactions;Patients;Pattern;Pediatric Hospitals;Persons;pharmacologic;Phenotype;postnatal;Posture;prevent;Primary Dystonias;programs;pup;Purkinje Cells;Research;Research Institute;respiratory;Role;Scientist;Severities;Signal Transduction;skills;Smooth Muscle;Source;stem;Symptoms;Testing;Texas;Thalamic structure;therapeutic target;timeline;Training;Tremor;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Defining a Dystonia Specific Spiking Signature in Cerebellar Nuclei Cells

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AURORA

ORG_NAME: GREFFEX, INC.

PI_NAMEs: STAERZ, UWE  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Clinical;Clinical Trials;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Evaluation;Formulation;immunogenicity;Individual;influenza virus vaccine;manufacture;Phase I/II Clinical Trial;response;Safety;stability testing;Toxicology;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccines for Influenza


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Telehealth

ORG_CITY: LOS ALTOS

PI_NAMEs: CHEN, GRACE  (contact)

PROJECT_TERMS: Address;American;American Cancer Society;anti-cancer research;Architecture;Area;Assessment tool;Back;Behavior Therapy;Cancer Center;cancer diagnosis;Cancer Patient;cancer prevention;cancer risk;cancer type;care providers;Caring;Categories;Certification;Chicago;Client;Clinic;Clinical;Clinical Management;cloud based;Code;Communication;Communities;Complement;Complex;Computer software;Consensus;Consent Forms;Consult;Contracts;cost effective;Data;Data Collection;Data Element;data exchange;data integration;data management;Data Reporting;Databases;design;Development;Devices;Diet;digital health;digital healthcare;digital platform;digital tool;Education;Eligibility Determination;encryption;Ensure;Environment;Environmental Risk Factor;Epidemiology;experience;Family;Family Cancer History;Fast Healthcare Interoperability Resources;feasibility testing;Feedback;firewall;flexibility;Funding;General Population;Genetic;genetic testing;Guidelines;Health;health care service organization;Health Insurance Portability and Accountability Act;Health Personnel;Health system;Health Technology;Healthcare;Healthcare Systems;high risk;Home;Hospitalization;Hypertension;indexing;individual patient;Infrastructure;innovation;Institution;Insurance Carriers;interest;Language;Laws;Life Style;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Managed Care;Medical;Medical Care Team;Medical center;Medical Device;medical specialties;Monitor;National Comprehensive Cancer Network;Notification;Nurses;Obesity;Oncologist;Patient Care;patient engagement;patient expectation;patient health information;patient navigation;Patient risk;Patient Self-Report;Patients;Persons;Phase;Physicians;Population;Prevention Guidelines;Prevention program;Preventive;Primary Care;Primary Care Physician;primary care practice;primary care provider;Privacy;privacy protection;Process;Production;programs;Protocols documentation;Provider;Publishing;Recommendation;Recording of previous events;recruit;remote health care;remote patient monitoring;Reporting;repository;Research;Research Personnel;Review Literature;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;routine screening;Running;rural area;Sampling;San Francisco;satisfaction;Schedule;Science;screening;Secure;Security;service organization;Services;software development;Stream;supplemental screening;Surveys;systematic review;Talents;telehealth;Telemedicine;Testing;Tobacco use;tool;United States Preventative Services Task Force;Update;usability;user-friendly;Vaccines;Visit;wearable data;web services;Work

PROJECT_TITLE: TOPIC 453: A DIGITAL TOOL TO INTEGRATE CANCER PREVENTION WITHIN PRIMARY CARE.


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: Branford

ORG_NAME: ABBRATECH, INC.

ORG_STATE: CT

PHR: Narrative Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. The challenges of this include immunogenicity limitation, long-term infection in patients, broad neutralizing capabilities depend on rare natural occurring chances. Even after neutralizing Abs isolated are from human sample, they still need further characterization using epitope binning and determination of specificities to avoid off target effect. Therefore, a systematic method for exploring the entire solvent-exposed surface of a virus that can identify all potential sites on the virus which can affect its life cycle would have significant impact and it is innovative. Our systematic method for exploring the entire protein surface of a virus that can identify all potential sites on the virus which can affect its life cycle is proactive, innovative, and significant.

PI_NAMEs: LI, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Affect;Affinity;Amino Acids;Animals;Antibodies;Antigens;Autoantigens;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Cells;Communicable Diseases;COVID-19 pandemic;Data;design;Development;empowerment;Epitopes;Evolution;fighting;Generations;Genetic Polymorphism;hands-on learning;Hemagglutinin;Human;Immune Targeting;Immune Tolerance;Immunization;Immunize;immunogenicity;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunologic Surveillance;Infection;Influenza;Influenza A virus;influenzavirus;innovation;Life Cycle Stages;Measurement;Membrane Proteins;Methods;Modeling;Molecular Conformation;Mutation;neutralizing antibody;novel;pandemic virus;Patients;Phase;phase 1 study;Pilot Projects;Protein Binding Domain;Proteins;Proteome;Protomer;receptor binding;Receptor Cell;Rest;Sampling;screening;Severe Acute Respiratory Syndrome;Site;Solvents;Specificity;stem;Structure;Surface;System;Technology;technology development;vaccination strategy;Vaccines;Validation;Variant;Virus

PROJECT_TITLE: Structure-guided neutralizing antibodies developed using EpiVolve technology


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE: The proposed Consortium offers optimal organization for the accelerated recruitment of a racially diverse cohort of SuperAgers so that they can be more fully characterized neuropsychologically, neuropathologically, psychophysiologically, and molecularly. The planned activities of the Consortium will help isolate factors important for promoting successful cognitive aging and potentially also for avoiding age-related brain diseases such as Alzheimer's disease.

PI_NAMEs: GEULA, CHANGIZ ;MESULAM, MAREK-MARSEL M;ROGALSKI, EMILY J (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;Anatomy;Behavioral;behavioral neurology;Biological;Biology;Biometry;Biostatistics Core;Black race;blood product;Brain;Brain Diseases;brain tissue;Canada;case control;Clinical;Cognition;Cognitive;Cognitive aging;cohort;Collaborations;comparison control;Databases;Dementia;demographics;Diagnosis;Digital biomarker;Elderly;Enrollment;Extramural Activities;Funding;Genetic;genetic profiling;Goals;Health;human old age (65+);Illinois;Image;Immune;Impaired cognition;Individual;Inflammatory;Infrastructure;Investigation;Leadership;Life;Memory;Michigan;minority communities;Molecular;multidisciplinary;Nerve Degeneration;Neurobiology;neuroimaging;Neurons;neuropathology;Neuropsychology;novel;Ontario;organizational structure;Outcome;Participant;Pathologic;Pathway interactions;Pattern;Performance;Peripheral;Phenotype;Physical activity;Physiological;Plasma;preservation;prevent;Procedures;programs;protein profiling;Psychophysiology;psychosocial;Race;racial diversity;recruit;Research;Research Personnel;Research Project Grants;resilience;resilience in aging;Resistance;response;Site;Sleep;social engagement;socioeconomics;Specimen;Standardization;Structure;super ager;System;temporal measurement;Testing;transcriptomic profiling;United States;wearable device;Wisconsin

PROJECT_TITLE: Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)


NIH_SPENDING_CATS: Aging

PI_NAMEs: ROGALSKI, EMILY J (contact)

PROJECT_TERMS: Accountability;Achievement;Biometry;Biostatistics Core;Clinical;Cognitive;cohort;Collaborations;Data;Data Analyses;Data Collection;data collection site;data dictionary;data integration;data management;data quality;Data Reporting;data repository;data sharing;data submission;Database Management Systems;Databases;Development;Ensure;Episodic memory;Extramural Activities;Funding;Future;Genetic;Goals;Human Resources;Image;Infrastructure;Investigation;Leadership;Link;meetings;Monitor;multidisciplinary;Nature;Network-based;neuropathology;operation;Participant;Pathway interactions;Performance;Play;Productivity;programs;Publications;quality assurance;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;research study;resilience in aging;Resources;Role;Safety;Sample Size;Site;Statistical Models;success;Sum;super ager;Tissues;training opportunity;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative/Biostatistics Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

PI_NAMEs: ROBERTS, ANGELA CHRISTINE (contact)

PROJECT_TERMS: Acceleration;Acoustics;Address;Adult;Affect;Age;age related;age related cognitive change;age related decline;Aging;aging mechanism;Autonomic nervous system;Bathing;Behavior;Behavioral;Behavioral Mechanisms;Biological;Blood Pressure;Blood Vessels;Body System;Clinic Activity;Clinical;Clinical assessments;Cognitive;Cognitive aging;cohort;comparison control;Complex;Data;Data Reporting;Dementia;Economics;Electrocardiogram;Enrollment;Entropy;Equilibrium;Exercise;flexibility;Fostering;Frequencies;Future;Geroscience;Goals;Heart Rate;Home;Hour;Image;Immune;Impaired cognition;indexing;Link;Literature;Measurement;Measures;Mediator;Memory;Monitor;Neighborhoods;Nervous System Physiology;neural;novel;novel strategies;older adult;Oxygen;Participant;Pathway interactions;Patient Self-Report;Pattern;Performance;Peripheral;Persons;Phenotype;Physical activity;Physiological;poor sleep;preservation;Process;Race;Reaction;remote monitoring;Research;resilience in aging;Resources;Respiration;response;sedentary;sensor;Series;sex;Signal Transduction;Skin;Sleep;Sleep Fragmentations;sleep pattern;sleep quality;Sleep Stages;social;social engagement;Social Functioning;socioeconomics;standardize measure;super ager;System;Testing;Time;verbal;wearable device;wireless;Work

PROJECT_TITLE: Vascular and Behavioral Determinants of Superior Memory Performance from Continuous Monitoring of Everyday Activities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: HUENTELMAN, MATT  (contact)

PROJECT_TERMS: Acute;Age;age related;age related cognitive change;age related decline;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Anterior;Antibodies;Autoimmune Diseases;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;Brain;brain health;brain tissue;cell type;Cells;Cessation of life;Characteristics;cingulate cortex;Cognition;Cognition Disorders;Cognitive;cognitive capacity;cohort;comparison control;cytokine;cytokine release syndrome;Databases;design;Disease;disorder risk;DNA Sequence;Elderly;entorhinal cortex;Exhibits;Freezing;Frequencies;Gene Expression Profile;General Population;Genes;genetic risk factor;genetic variant;Genetic Variation;Germ Lines;Health;Human Genetics;Immune;Immune response;Immune system;Immunogenetics;Individual;Infection;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;life span;Link;Measurement;Measures;Memory;Microglia;Middle frontal gyrus structure;Molecular;Neurodegenerative Disorders;neuroprotection;normal aging;Organ;Organism;Participant;Pathway interactions;peer;Peripheral;Phenotype;Plasma;Play;Process;Research Design;resilience;resilience in aging;Resistance;response;Role;Sampling;single nucleus RNA-sequencing;Stress;super ager;System;T cell receptor repertoire sequencing;T-Lymphocyte;targeted sequencing;trait;transcriptome;Variant;Viral;Work

PROJECT_TITLE: Immune and inflammatory system changes in SuperAgers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WEINTRAUB, SANDRA  (contact)

PROJECT_TERMS: Address;Age;age related;age related decline;aged;Aging;Alzheimer's Disease;Alzheimer's disease risk;Anterior;Biological;Black race;Blood specimen;Brain;Brain Diseases;Canada;Caucasians;cerebral atrophy;Chronology;Clinical;Cognition;Cognitive;Cognitive aging;cognitive reserve;cohort;Data;Data Collection;data harmonization;data management;Database Management Systems;Databases;Dementia;Elderly;Enrollment;Episodic memory;Extramural Activities;Funding;Genetic;Health;Illinois;Image;impression;inclusion criteria;Infrastructure;Investigation;Label;late life;Life Style;Longitudinal Studies;longitudinal, prospective study;Magnetic Resonance Imaging;Memory;Memory Loss;Michigan;multidisciplinary;Neuroanatomy;Neurocognitive;Neuropsychology;older adult;Ontario;Outcome;outreach;Participant;participant enrollment;Pathway interactions;peer;Performance;Population;Procedures;Protocols documentation;psychosocial;Race;racial diversity;recruit;Research;Research Project Grants;resilience;resilience in aging;Resistance;resistance mechanism;Resources;Sample Size;Site;social relationships;Standardization;super ager;Thinness;Time;United States;Universities;wearable sensor technology;Well in self;Wisconsin

PROJECT_TITLE: Clinical/Imaging Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: GEULA, CHANGIZ  (contact)

PROJECT_TERMS: Address;African American;age effect;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Anatomy;Anterior;Archives;Autopsy;Biological;Biological Factors;Biological Markers;Black race;Blood;Blood Banks;Blood Cells;blood product;Brain;brain tissue;Characteristics;cholinergic;cingulate cortex;Cognition;Cognitive;cognitive function;cohort;Collection;combat;comorbidity;Data;Dementia;density;Diagnosis;DNA;DNA analysis;Elderly;Episodic memory;exome;Extramural Activities;Freezing;Funding;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genomics;Goals;inflammatory marker;Intervention;Investigation;Light;MAP2K3 gene;Measures;Memory Loss;Molecular;Nerve Degeneration;nerve supply;Neurofibrillary Tangles;neurofilament;Neurons;neuropathology;novel;Participant;Pathologic;Pathology;Pathway interactions;peer;Performance;Phenotype;Plasma;preservation;Productivity;programs;protein TDP-43;Research Personnel;resilience;resilience in aging;Resistance;Resources;super ager;Synapses;Tissues;transcriptome;transcriptomics;Universities;Variant;white matter

PROJECT_TITLE: Biospecimen/Neuropathology Core


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Chronic Pain;Clinical Research;Disability Research;Immunotherapy;Mental Health;Neurosciences;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE  Persistent pain after injury, surgery and other forms of trauma is common and results in poor functional recovery as well as increased exposure to opioids. Our evolving understanding of immune system function and recently collected data suggest that B lymphocyte activation and autoantibody generation may underlie this important cause of chronic pain. Validation of B cells as a target for the prevention and treatment of posttraumatic pain is therefore a novel yet highly plausible goal.

PI_NAMEs: CLARK, DAVID J. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Adaptive Immune System;Address;adverse outcome;affective disturbance;Age;Animals;anti-CD20;Antibodies;Anxiety;Autoantibodies;Autoimmunity;B cell therapy;B-Cell Activation;B-Lymphocytes;Behavioral;Biochemical;Canis familiaris;Caring;Cell Physiology;Cells;Chronic;Chronic disability;chronic pain;Chronic pain syndrome;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Communication;cost;Data;design;Devices;disability;Disability outcome;Disease;efficacy testing;Elderly;Evaluation;Experimental Designs;experimental study;Exposure to;Flow Cytometry;Foundations;Fracture;functional loss;functional outcomes;gait examination;Generations;Goals;Heart;Human;human subject;humoral immunity deficiency;IL6 gene;Immobilization;Immune;immune modulating agents;Immune system;immune system function;Immunoglobulin M;immunoregulation;Impaired cognition;improved;Individual;Injury;innovation;Interleukin-6;Intervention;Joints;Knee;knee replacement arthroplasty;Laboratory Study;Lead;Ligation;limb fracture;limb injury;Limb structure;Lymphocyte Activation;Mediating;Medical;meetings;Memory;Modeling;mouse model;Mus;Nerve;nerve damage;nerve injury;neuropsychiatry;Nociception;novel;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use;opioid use disorder;Osteotomy;Outcome;Outcome Measure;Pain;Pain Research;Patients;Perioperative;Persistent pain;pharmacologic;Phenotype;Positioning Attribute;Postoperative Pain;Pre-Clinical Model;prevent;Prevention;Production;Productivity;programs;Protocols documentation;Questionnaires;Recovery;Recovery of Function;Research;Research Personnel;Risk Factors;Rodent;Role;Sampling;Schedule;Self Direction;Serum;Severities;sex;soft tissue;Soft Tissue Injuries;Specificity;spontaneous pain;Surgical incisions;Surgical Models;Sympatholytics;Testing;Therapeutic;tibia;tissue trauma;tool;translational study;Trauma;Trauma recovery;Validation;Work;young adult

PROJECT_TITLE: B Lymphocyte-Mediated Autoimmunity in Pain After Trauma


NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: NAVINETICS NEUROMODULATION, INC.

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed studies consist of three Aims in which, in Aim 1, WINCS International LLC, in partnership with Mayo Clinic Neural Engineering Laboratories and Division of Engineering, will finalize the development of a novel neurochemical/electrophysiological recording and stimulating instrument, called Multifunctional Apparatus for Voltammetry, Electrophysiology and Neuromodulation (MAVEN), together with a sophisticated user-friendly software interface, for a broad range of clinical neuroscience research in subjects undergoing intraoperative brain neurosurgeries. In Aim 2, overall development and construction plans for the MAVEN system will ensure that device manufacturing processes and design history files meet regulatory Design Control and medical safety requirements necessary to obtain approval for an FDA Investigational Device Exemption (IDE). Aim 3 is designed to integrate several MAVEN recording protocols into existing intraoperative clinical neurosurgical procedures (e.g., deep brain stimulation neurosurgeries and cortical lobectomies) using a large animal model (swine), including confirming MAVEN’s ability to reliably record neurochemical and electrophysiological events (e.g., dopamine, serotonin, and adenosine, and action/local field potential activity, respectively) for future use of the system in IDE-enabled mechanistic clinical studies.

PI_NAMEs: BENNET, KEVIN ELLIOTT;LEE, KENDALL  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Action Potentials;Adenosine;Amplifiers;Animal Model;Area;Basic Science;Brain;Brain region;carbon fiber;Clinic;Clinical;Clinical Protocols;Clinical Research;commercialization;Communities;Complex;computer science;Computer software;Custom;Data;Deep Brain Stimulation;design;Development;Devices;Documentation;Dopamine;Electric Stimulation;Electrochemistry;Electrodes;Electrophysiology (science);Elements;Engineering;Ensure;Epilepsy;Essential Tremor;Event;extracellular;Family suidae;FDA approved;Feedback;Functional disorder;Future;Goals;good laboratory practice;high dimensionality;Human;implantation;innovation;instrument;International;Investigation;Laboratories;Learning;Link;Lobectomy;manufacturing process;Measurement;Measures;Medical;meetings;Mental Depression;Microelectrodes;millimeter;Modality;Monitor;motor behavior;multimodality;neural;neurochemistry;neurophysiology;neuroregulation;Neurosciences;Neurosciences Research;neurosurgery;Neurosurgical Procedures;neurotransmission;Neurotransmitters;next generation;Noise;Norepinephrine;novel;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Outcome;Parkinson Disease;Patients;Pattern;Periodicity;Phase;phase change;porcine model;pre-clinical;Preparation;Procedures;Process;Protocols documentation;Recording of previous events;Regulation;Research Personnel;Research Subjects;Resolution;response;Rest;reward processing;Safety;safety study;Scanning;Series;Serotonin;Signal Transduction;Small Business Technology Transfer Research;software development;spatiotemporal;Specificity;System;Techniques;Technology;Testing;Time;Tissues;Toxicology;United States National Institutes of Health;user friendly software;user-friendly;Validation;wireless

PROJECT_TITLE: An Integrated Neurochemical/Electrophysiological Recording and Neuromodulation System for Basic and Clinical Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Medications that provide pain relief without opioid-like side effects are urgently needed to treat the hundred million Americans who suffer from chronic pain. Our research pursues a novel analgesic mechanism that involves the brain’s affective pain circuits, which confer the emotional response to pain and underlie human suffering during painful experiences. This HEAL Initiative project will identify novel analgesic targets within these brain circuits, setting the stage for new drugs that can alleviate the emotional suffering of pain patients without the addictive side-effects traditionally associated with opiates.

PI_NAMEs: SCHERRER, GREGORY  (contact)

PROJECT_TERMS: abuse liability;Acute Pain;Affect;Affective;Agonist;allodynia;American;Amygdaloid structure;Analgesics;Animal Model;Animals;Anterior;antinociception;Anxiety;Area;Behavior;Behavioral Assay;Bioinformatics;Brain;brain tissue;Breathing;Catalogs;cell cortex;Cells;chronic pain;chronic pain patient;cingulate cortex;cingulotomy;Clinical;Code;Collaborations;comorbidity;Coupled;designer receptors exclusively activated by designer drugs;Dimensions;Disease;Dissociation;dosage;Drug Modulation;Drug Targeting;Electrophysiology (science);Emotional;Emotions;experience;Fluorescence-Activated Cell Sorting;Fluorescent in Situ Hybridization;G-Protein-Coupled Receptors;Genetic;Genetic Complementation Test;genetic manipulation;Genomics;Helping to End Addiction Long-term;hippocampal pyramidal neuron;Human;human tissue;imaging study;In Situ Hybridization;in vivo;in vivo imaging;Label;Lateral;Light;Mechanics;Mediating;Mental Depression;Methods;Molecular;Monitor;mouse genetics;Mus;negative affect;neural;neural circuit;Neurons;neurophysiology;Nociception;Nociceptors;novel;novel therapeutics;Opioid;Opioid Analgesics;Opioid Receptor;Pain;pain patient;Pain quality;pain relief;painful neuropathy;Pathway interactions;Patients;Pattern;Peripheral nerve injury;Pharmaceutical Preparations;Population;promoter;Property;Proteins;Pyramidal Cells;receptor;Reflex action;Reporting;Research;response;reward processing;Rewards;RNA;Rodent;Role;Safety;Science;Sensory;Shapes;side effect;single-cell RNA sequencing;Slice;Somatostatin Receptor;spontaneous pain;SSTR2 gene;Stimulus;Testing;Tracer;Translating;Validation;Viral;Visualization;Whole Body Plethysmography;Wild Type Mouse;Withdrawal

PROJECT_TITLE: Targeting GPCRs in amygdalar and cortical neural ensembles to treat pain aversion


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Understanding the aggregation of the β-amyloid peptide to form toxic oligomers is fundamental to understanding the molecular basis of Alzheimer’s disease. This project seeks to understand the structures and biological impacts of these elusive oligomers, through the design, synthesis, and study of synthetic peptides that are based on the β-amyloid peptide and form well-defined oligomers that can be studied in exquisite detail. These studies will advance the field of Alzheimer’s disease research by providing a molecular-level understanding of key species in neurodegeneration and identifying molecular targets for developing diagnostics and therapies.

PI_NAMEs: NOWICK, JAMES S (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta oligomer;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Antibodies;Biological;Biology;Biomedical Research;Biophysics;Brain;brain cell;cell type;Chemicals;crosslink;Crystallography;design;Diagnostic;disulfide bond;Doctor of Philosophy;Engineering;Event;experimental study;Fellowship;Funding;Immunologics;immunoreactivity;Investigation;Laboratories;Mentorship;Minority Graduate Student;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;mouse model;Mus;Nerve Degeneration;Neurons;Oryctolagus cuniculus;parent grant;Peptide Fragments;Peptides;polyclonal antibody;Property;protein aminoacid sequence;Proteins;Research;Research Personnel;Scientist;Slice;Structure;synthetic peptide;Training;Underrepresented Minority;X-Ray Crystallography

PROJECT_TITLE: Structural and Biological Characterization of Diverse Oligomers Derived from Abeta


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Early fetal brain development is characterized by waves of neurogenesis and programmed cell death with microglia as the predominant glia interacting with neural progenitor cells to establish early brain circuitry. Perturbations to the fetal brain can lead to increased risk of neurodevelopmental disorders. The goal of the proposed studies is to utilize cerebral organoids and induced pluripotent stem cell-derived microglia to improve our understanding of the molecular mechanisms that drive neuron-microglia interactions in the maintenance of fetal brain homeostasis and how these mechanisms are altered in the course of disease.

PI_NAMEs: HAN, CLAUDIA Z (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adopted;Affect;analytical method;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Automobile Driving;Award;Behavior;Behavioral;Biological Models;Brain;brain cell;brain circuitry;Brain Pathology;Cell Communication;Cell Death;cell type;Cells;Cerebrum;Chromatin;clinically relevant;Coculture Techniques;Communication;Communities;CRISPR/Cas technology;critical period;Data;Data Collection;Development;Disease;DNA Binding;Electrophysiology (science);Embryo;Ensure;Environment;Epigenetic Process;epigenome;experience;Exposure to;fetal;Fetal Development;First Pregnancy Trimester;Functional disorder;Gene Expression Regulation;gene regulatory network;genome editing;Goals;Grant;Health;Heterogeneity;Homeostasis;Human;Human Characteristics;human fetal brain;human fetal brain tissue;Immune;immune activation;improved;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Knowledge;Ligands;Macrophage;Maintenance;Mediating;Mentors;Microglia;migration;Modeling;Molecular;Morphology;mouse development;mouse model;Mus;nerve stem cell;Nervous System Disorder;neural;neural circuit;neural network;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;neuronal circuitry;Neurons;neuropathology;neurotransmission;neurotrophic factor;neurotropic;notch protein;Organoids;Outcome;Pathogenesis;Phase;Phenotype;pleiotropism;postnatal;prenatal;Process;Publications;Publishing;receptor;Receptor Signaling;Research;Research Personnel;response;Risk;Risk Factors;Second Pregnancy Trimester;Series;Signal Transduction;skills;Specimen;Stimulus;Synapses;synaptic pruning;System;Technology;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;tool;Training;transcription factor;Transducers;Up-Regulation

PROJECT_TITLE: Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chemical Synthesis of Complex Natural Products for Translational Science The goals of the continuing MIRA research program (R35GM118173) are to 1) develop novel synthetic methods and expedient approaches to important, unstudied classes of bioactive natural products and to 2) explore fundamental questions of compound mechanism of action in clinical and translational research collaborations. The relevance to public health of the planned studies entails identification of novel, biologically active agents for use as pharmacological therapies for human cancers as well as viral, fungal, and bacterial illnesses.

PI_NAMEs: PORCO, JOHN A. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(07)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Genetics;Human Genome;Rheumatoid Arthritis

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Knowledge of the specific antigens T cells recognize through their T cell receptor is foundational for our understanding of why and how T cells are involved in autoimmune diseases. This proposal focuses on identifying the antigenic targets of clonally expanded CD4+ T cells from rheumatoid arthritis synovium and understanding how such antigens relate to autoantibody responses. By uncovering the molecular targets of synovial CD4+ T cells, we can gain a richer understanding of what proteins may become dysregulated in disease, how tolerance is broken leading to autoantibody formation, and help inform new therapeutic targets to achieve immunological tolerance.

PI_NAMEs: KOHLGRUBER, AYANO CHRISTINE (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Affinity;Alleles;Anti-citrullinated peptide antibody;Antibodies;Antibody Formation;Antibody Repertoire;antigen-specific T cells;Antigens;Area;Arginine;Arthritis;Autoantibodies;Autoantigens;Autoimmune Diseases;autoreactivity;Award;B-Cell Activation;B-Lymphocytes;Bar Codes;Binding;Bioinformatics;Biological Assay;career;career development;CD4 Positive T Lymphocytes;Cell Separation;Cells;Cellular biology;Chronic;citrullinated protein;Citrulline;Clonal Expansion;Clone Cells;Coculture Techniques;Collaborations;Data;Data Set;Dedications;Development Plans;Disease;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Enzymes;Epitopes;experience;experimental study;Faculty;Flow Cytometry;Frequencies;functional genomics;Genetic;Genetic Polymorphism;Genetic Screening;Genetic Transcription;genome-wide;Goals;Helper-Inducer T-Lymphocyte;Histocompatibility Antigens Class II;HLA-DRB1;Hospitals;Human;Immune response;Immune Tolerance;Immunologics;Immunology;Individual;Inflammatory;interest;joint destruction;Joints;Knowledge;Laboratories;Learning;Libraries;Link;Lymphocyte;Lymphocyte Biology;Lymphoid;Major Histocompatibility Complex;Maps;Mediator;medical schools;memory CD4 T lymphocyte;Mentors;Molecular;Molecular Target;new therapeutic target;novel;pathogenic autoantibodies;Pathogenicity;Pathologic;Pathology;Patients;Peptides;Peripheral;peripheral blood;Phage ImmunoPrecipitation Sequencing;Play;Population;Positioning Attribute;Post-Translational Protein Processing;Process;Production;Proteins;Research;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Role;Scientist;screening;seropositive;Serum;single-cell RNA sequencing;Site;Specificity;Susceptibility Gene;Synovial Fluid;Synovial Membrane;T cell receptor repertoire sequencing;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Technology;technology development;tenure track;Testing;Tissues;Training;transcriptomics;translational immunology;Woman;Work

PROJECT_TITLE: Decoding synovial CD4+ T cell antigen specificities in Rheumatoid Arthritis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Electronic Nicotine Delivery Systems (ENDS) use continues to increase among young adults, yet research on effective intervention is lacking. A mobile health (mHealth) intervention that utilizes translations of effective smoking cessation materials and pharmacotherapy may be a promising avenue for intervention. The proposed study uses focus groups and a pilot study (Phase 1) and a randomized controlled trial (Phase 2) to develop and evaluate a novel mHealth text-based intervention for young adult ENDS and dual product (ENDS and combustible cigarette) users.

PI_NAMEs: BRETT, EMMA  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;acceptability and feasibility;addiction;addiction liability;Address;Adolescence;Adverse effects;Affect;Area;Behavior;behavior change;Behavioral;Biochemical;cancer risk;career;Cigarette;cigarette smoking;cigarette user;Clinical;Cognitive;Collaborations;combustible cigarette;comparison intervention;cost;Data;Dependence;Development;Devices;Drops;Education;effective intervention;effective therapy;Effectiveness;effectiveness evaluation;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;epidemiologic data;evidence base;experience;Feedback;Focus Groups;follow up assessment;follow-up;Frequencies;Funding;Health;Individual;interest;Intervention;intervention effect;intervention refinement;Literature;Marijuana;Mentors;Mentorship;mHealth;mhealth interventions;Modality;Motivation;new technology;Nicotine Dependence;nicotine replacement;nicotine use;novel;Outcome;Participant;Pattern;Pharmacotherapy;Phase;Pilot Projects;Population;Predisposition;Prevalence;prevent;primary outcome;programs;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Resources;Running;Safety;Sampling;Schedule;Scientist;secondary outcome;skills;Smoking;smoking cessation;Smoking Cessation Intervention;standard care;substance use;Text Messaging;text messaging intervention;Therapeutic Intervention;therapy development;Time;Tobacco;tobacco control;tobacco products;Tobacco use;tobacco user;Training;Translations;Update;uptake;vaping;web site;Work;young adult;Youth

PROJECT_TITLE: Development of a mobile health intervention for electronic cigarette use among young adults


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project narrative: This diversity supplement will provide Mr. Rojas with the opportunity and training to lead an independent project that focuses on the role of tetrabromobisphenol A and its effects on naa10-based Nt-acetylation. He will leverage training and implementation of microinjections, cloning, protein purification and other molecular biology assays to test the hypothesis that TBBPA-induced developmental delays are caused partly by naa10-mediated inhibition of Nt-acetylation. Coupled with the parent R03, this supplement will provide him with robust laboratory-based training in molecular toxicology, scientific writing and presentations as well as professional networking that will contribute to his career goals.

PI_NAMEs: DASGUPTA, SUBHAM  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acetylation;Acetyltransferase;Area;Biological Assay;career;career development;career networking;Cloning;Coupled;data integration;Development;Developmental Delay Disorders;developmental toxicity;Embryo;Genes;Genome;Goals;Grant;Histone Acetylation;Injections;Laboratories;Lead;Learning;Link;Mediating;Mentors;Messenger RNA;Microinjections;Molecular;Molecular Biology;Molecular Toxicology;N-terminal;parent grant;Parents;Peptides;Phenotype;protein purification;Proteome;Research;Role;Science;symposium;Techniques;Testing;tetrabromobisphenol A;Toxic effect;Training;Writing

PROJECT_TITLE: Uncovering the Role of Histone Acetylation in Tetrabromobisphenol A-induced Developmental Toxicity during Zygotic Genome Activation


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE This Training Program based in a large Division of Pediatric Rheumatology (PR) with several NIH center grants and NIH-funded investigators seeks to equip PR fellows with the investigative skills necessary to succeed in research careers. The research training activities will have two focus areas: (1) application of genomics, epigenetics, proteomics, and metabolomics to advance PR translational research, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. It is expected that this program will enlarge the number of PR researchers, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.

PI_NAMEs: GROM, ALEXEI A (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Childhood;Training Programs

PROJECT_TITLE: CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCH


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Basic Science;Leishmaniasis;Lutzomyia genus;Phlebotominae;Phlebotomus;repository;Resources;United States National Institutes of Health

PROJECT_TITLE: Provision of Phlebotomine Sand Flies for the MID-BRR (BEI) Repository


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: RELEVANCE (See instructions): Disease and injury to the visual cortex results in profound impairments in vision that impact daily life. It is  increasingly clear that to improve the diagnosis of visual disorders, as well as to build effective visual  prostheses to repair visual dysfunction, we must understand the neural computations of the visual system.  The proposed research aims to identify these computations by large-scale neural recordings and  advanced AI modeling to improve our understanding of the visual system and its disorders.

PI_NAMEs: SMITH, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Algorithms;area V4;artificial intelligence model;Attention;Behavior;Brain;Bypass;cerebral atrophy;clinical diagnosis;Clinical Treatment;Clip;Code;Color;Computer Models;Data;Data Collection;data modeling;deep neural network;Detection;Diagnosis;Disease;dorsal visual stream;experimental study;extrastriate visual cortex;Face;Human;Impairment;improved;Injury;innovation;Instruction;interdisciplinary collaboration;Knowledge;large scale data;Life;Link;Macaca;Methods;Modeling;Motion;Motion Sickness;Nature;network models;neural;Neural Network Simulation;Neurodegenerative Disorders;Neurons;Neurosciences;object recognition;Ocular Prosthesis;Perception;predictive modeling;Procedures;programs;Recording of previous events;repaired;Research;Research Personnel;Resources;response;Retina;Shapes;Stimulus;Synapses;System;Testing;Texture;Time;Training;training data;Uncertainty;V4 neuron;Vision;Vision Disorders;Visual;Visual Cortex;visual dysfunction;visual processing;Visual System;Work

PROJECT_TITLE: CRCNS: Unraveling the visual system's temporal code for dynamic scene processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (50)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE (Parent Award): The Yale Head and Neck SPORE is a team of clinical and laboratory researchers studying the problem of treatment resistance in head and neck cancer. Each of three projects brings a basic and clinical research leader together to study ways to overcome resistance to common therapies, such as cetuximab and cisplatin, as well as to find ways to make HPV-driven cancers more sensitive to immunotherapy; There are clinical trials to treat patients with HPV-negative and HPV-driven cancer before they go to surgery. The projects are supported by core facilities to provide administrative, pathology and statistical support, and there are funds to support new projects and new investigators.

PI_NAMEs: BURTNESS, BARBARA  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;aurora kinase A;Basic Science;Bioinformatics;Biometry;career;Cessation of life;Cetuximab;checkpoint inhibition;Cisplatin;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;Core Facility;Correlative Study;Data;demethylating therapy;demethylation;Development;Disease;DNA Damage;EGFR inhibition;Family member;Fostering;Foundations;Funding;Future;Generations;Genomics;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;HPV negative;HPV-negative head and neck cancer;Human;Human Papillomavirus;Immune;Immune response;Immunotherapy;improved;inhibitor;insight;Institution;Laboratories;Malignant Neoplasms;Mediating;Methodology;Modality;Modeling;Molecular Conformation;next generation;novel;novel strategies;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;parent project;Pathology;Patients;Pharmacodynamics;programs;Recurrence;Research;Research Personnel;Resistance;Resources;Safety;Scientist;targeted treatment;therapy resistant;Training;Translational Research;translational scientist;treatment response;tumor;Validation;Yale Cancer Center

PROJECT_TITLE: Yale Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck Cancer


PHR: NARRATIVE The Yale Head and Neck SPORE is a team of clinical and laboratory researchers studying the problem of treatment resistance in head and neck cancer. Each of three projects brings a basic and clinical research leader together to study ways to overcome resistance to common therapies, such as cetuximab and cisplatin, as well as to find ways to make HPV-driven cancers more sensitive to immunotherapy. There are clinical trials to treat patients with HPV-negative and HPV-driven cancer before they go to surgery. The projects are supported by core facilities to provide administrative, pathology and statistical support, and there are funds to support new projects and new investigators.

PROJECT_TERMS: Address;Animals;apolipoprotein B mRNA editing enzyme;aurora kinase A;barrier to care;Basic Science;Bioinformatics;Biometry;Cancer Biology;Cancer Center;career;Cell Line;Cells;Cellular biology;Cessation of life;Cetuximab;checkpoint inhibition;Cisplatin;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;conventional therapy;Core Facility;Correlative Study;curative treatments;Data;demethylating therapy;demethylation;Development;Disease;DNA Damage;EGFR inhibition;Epidermal Growth Factor Receptor;ERBB3 gene;Family;Family member;Fostering;Foundations;Fox Chase Cancer Center;Functional impairment;Funding;Future;Generations;Genes;Genomics;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;HPV negative;HPV-negative head and neck cancer;Human;Human Papillomavirus;Immune;Immune response;Immunology;Immunotherapy;improved;inhibitor;insight;Institution;Laboratories;Link;Malignant Neoplasms;Mediating;Mentors;Methodology;Modality;Modeling;Molecular Abnormality;Molecular Conformation;mortality;Mutation;new therapeutic target;next generation;North Carolina;novel;novel strategies;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;overtreatment;Pain;Pathology;Patients;Pharmacodynamics;Pharmacology;polypeptide;programs;Proteins;Radiation;Radiobiology;Recurrence;Reproduction spores;Research;Research Personnel;Resistance;Resources;response;Role;Safety;Sampling;Scientist;Signal Transduction;Specimen;structural biology;System;targeted treatment;therapy resistant;TP53 gene;Training;Translational Research;translational scientist;Translations;treatment response;tumor;United States;Universities;Validation;virology;Yale Cancer Center


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: COLUMBIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE: Primary open angle glaucoma (POAG) is the most prevalent neurodegenerative disease of the optic nerve. Here, we propose to investigate the role of mitophagy impairment and mitochondrial dysfunction in glaucomatous neurodegeneration using both human and mouse models of POAG. Also, we will examine the therapeutic strategies to enhance mitophagy for the treatment of glaucoma.

PI_NAMEs: MADDINENI, PRABHAVATHI  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Advisory Committees;Autophagocytosis;Axon;axon injury;axonal degeneration;Axonal Transport;Biological Assay;Blindness;Brain;career;career development;Cell Physiology;Cell secretion;Cells;Chronic;Collaborations;conditional knockout;cytokine;Data;Demyelinations;Development;Electroretinography;endoplasmic reticulum stress;Enhancers;Environment;Event;experience;Eye;Failure;functional loss;Genus Hippocampus;Glaucoma;Glucocorticoids;Goals;Health;Homeostasis;Human;human model;human tissue;Immune;Impairment;improved;Infiltration;Inflammasome;Inflammatory;insight;Institution;Knockout Mice;Laboratory Research;Learning;LoxP-flanked allele;Measures;meetings;Mentors;Metformin;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Molecular;Monitor;mouse model;Mus;myocilin;Nerve Degeneration;Nerve Tissue;Neurodegenerative Disorders;neuroinflammation;neuronal cell body;neurotransmission;novel;novel therapeutics;Ocular Hypertension;Optic Nerve;optic nerve disorder;overexpression;Parkin;Pathologic;Pathology;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Phenotype;Physiologic Intraocular Pressure;PINK1 gene;postsynaptic;presynaptic;prevent;Primary Open Angle Glaucoma;Quality Control;Reporter;Research;Research Institute;Research Personnel;Retina;Retinal Ganglion Cells;Risk Factors;Role;Scientist;Stains;symposium;TdT-Mediated dUTP Nick End Labeling Assay;Techniques;Texas;Therapeutic;therapeutic target;TNF gene;Trabecular meshwork structure;Training;Transgenic Mice;Transgenic Organisms;Transmission Electron Microscopy;treatment strategy;Visual;Visual evoked cortical potential

PROJECT_TITLE: The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegeneration


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Alcohol Use Disorder (AUD) presents significant psychological and economic burdens, underscoring the need for a deeper understanding of its molecular underpinnings, especially the role of epigenetic modifications induced by alcohol-derived acetate. This supplementary grant proposal focuses on examining the transport mechanisms of alcohol-derived acetate into the brain, particularly through the monocarboxylate transporter MCT4, and its impact on histone acetylation in neurons and astrocytes. By advancing our knowledge of acetate transport and its epigenetic effects, this project will not only fill critical gaps in AUD research but also significantly enhance Naomi Kassahun’s training in molecular techniques and her development as a leader in the alcohol research field.

PI_NAMEs: MEWS, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acetates;addiction;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Applications Grants;Astrocytes;binge drinking;Brain;cell type;Chromatin;Chronic;Communities;Complement;Complex;design;Development;differential expression;Economic Burden;economic impact;Ensure;Epigenetic Process;epigenetic regulation;Ethanol Metabolism;Family;Fostering;Future;Hippocampus;Histone Acetylation;Individual;Investigation;Knowledge;Liver;Mediating;Metabolic;Modification;Molecular;Neurons;parent grant;Pathway interactions;Protein Isoforms;psychologic;Psychological Impact;Public Health;Regulation;Research;Role;Techniques;Training;Youth

PROJECT_TITLE: Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed research is relevant to Veterans because they are at higher risk for tauopathies, and this proposal aims to establish the consequences of the association of tau and frontotemporal dementia, a devastating tauopathy. The expected results will inform future efforts to clarify the relationship between tau and ribosomes on memory decline, a common symptom of virtually all dementias. Therefore, the proposed research is relevant to the NIH mission.

PI_NAMEs: ABISAMBRA, JOSE FRANCISCO (contact)

PROJECT_TERMS: Affinity;Biological Assay;Brain;brain dysfunction;brain tissue;Cells;common symptom;Complex;Data;Dementia;design;Frontotemporal Dementia;Functional disorder;Future;Goals;high risk;Human;Impairment;In Vitro;in vivo;in vivo Model;Individual;innovation;Knowledge;Link;Mediating;Memory;Memory impairment;Memory Loss;Mission;Modeling;Mus;Mutation;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Protein Biosynthesis;Proteins;Research;Ribosomes;Screening procedure;Symptoms;tau mutation;tau Proteins;Tauopathies;Testing;therapeutic target;Transcript;Translational Repression;Translations;United States National Institutes of Health;Veterans;virtual;Work

PROJECT_TITLE: Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia