ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: It is estimated that 1 in 4 current Veterans Affairs medical system users suffers from cardiovascular disease (CVD). The most common form of CVD is atherosclerosis, or hardening of the arteries. Despite advances in treatment, deaths due to CVD equal approximately 1 million Americans annually, making it the leading cause of mortality in both the Veteran and general population. Understanding the mechanisms of CVD so that new, more efficient therapies can be identified is imperative. This proposal seeks to understand how the immune response to oxidized lipoproteins, that form during atherosclerosis, affects disease progression. We also ask the important question of whether sex is a determining factor for these immune responses. With the increase in female Veterans (approximately 9% of total Veteran population), it is necessary to understand the role that sex plays in atherosclerosis. It is the ultimate goal of this research to define immune-mediated mechanisms of CVD so that new therapeutic targets can be identified.

PI_NAMEs: MAJOR, AMY S (contact)

PROJECT_TERMS: adaptive immunity;Affect;Age;American;Antibodies;Antigen-Antibody Complex;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Aorta;Arteries;atherogenesis;Atherogenic Diet;Atherosclerosis;B-Lymphocytes;BCL10 gene;Biological;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;CD11c Antigens;CD36 gene;CD4 Positive T Lymphocytes;Cell Reprogramming;Cells;Cessation of life;Chimera organism;Cholesterol;Chronic;Classification;Complex;cytokine;Data;Dendritic cell activation;Dendritic Cells;Disease;Disease Progression;draining lymph node;Epigenetic Process;epigenetic regulation;Equilibrium;Estrogen Replacements;Exposure to;Family;Female;Gene Expression Regulation;General Population;Glycolysis;Goals;Gonadal Steroid Hormones;Health;Hepatic;Human;Hyperlipidemia;IgG Receptors;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunoglobulin G;Immunologic Factors;improved;In Vitro;in vivo;in vivo Model;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;Interferon Type II;interleukin-23;ITGAX gene;Knowledge;Licensing;Ligation;Link;Lipoproteins;Liver;Low-Density Lipoproteins;Macrophage;male;Mediating;Medical;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;military veteran;Molecular;mortality;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Myocardial Ischemia;Natural Immunity;neutrophil;new therapeutic target;novel;Nuclear Translocation;Ovariectomy;oxidized LDL receptors;oxidized low density lipoprotein;Pathogenesis;Pathologic;Patients;Pattern;Play;Production;prototype;Publishing;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Research;response;Role;Severities;Severity of illness;sex;Sex Differences;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Sterility;Stimulus;Surface;System;T cell response;T-Lymphocyte;Testing;Th1 Cells;Therapeutic;Tissues;TLR4 gene;Training;Triglycerides;United States Department of Veterans Affairs;Up-Regulation;Veterans;Woman;Work;XCL1 gene

PROJECT_TITLE: Fc Receptors in Atherosclerosis: Linking Innate and Adaptive Immunity.


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA MEDICAL CENTER - LEXINGTON, KY

ORG_STATE: KY

PHR: Clinical evidence coupled with experience in contemporary military arenas clearly indicates that traumatic brain injury (TBI) is becoming a signature injury of war which makes our troops a high-risk population. In fact 6.7% of OEF/OIF veterans in 2009 were diagnosed with TBI and 73% of those were diagnosed with posttraumatic stress disorder (PTSD). At present there is no approved treatment for TBI due to an incomplete understanding of the underlying pathobiology. This proposal examines the potential of targeting mitochondrial biogenesis and push forward the repurposing of the FDA approved drugs formoterol and lasmiditan to limit the brain damage and dysfunction resulting from TBI.

PI_NAMEs: SULLIVAN, PATRICK G (contact)

PROJECT_TERMS: Adult;Animals;Award;Behavioral;Bioenergetics;Biogenesis;Biological Assay;Brain;brain dysfunction;Brain Injuries;Cell Count;Cell Physiology;Cells;central nervous system injury;Clinical;cognitive function;cognitive recovery;cohort;controlled cortical impact;Coupled;Data;Diagnosis;Diet;dosage;Dose;Energy Metabolism;experience;FDA approved;Female;formoterol;Glucose;Grant;high risk population;Hippocampus;Histologic;Histology;Homeostasis;Impaired cognition;Impairment;improved;in vivo;injured;Injury;Intervention;Ipsilateral;Knockout Mice;Label;Link;Liquid substance;Magnetism;male;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;metabolomics;Methods;military operation;Military Personnel;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;mitochondrial therapeutics;Modernization;Molecular;molecular marker;morris water maze;mRNA Expression;Mus;neurobehavioral;Neurocognition;Neurocognitive;neurogenesis;Neurons;neuropathology;novel;novel strategies;object recognition;Outcome Measure;Pathogenesis;Pathology;Pathway interactions;Performance;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacologic;Pioglitazone;Post-Traumatic Stress Disorders;PPAR gamma;prevent;primary outcome;Process;Production;prophylactic;protein expression;Proto-Oncogene Proteins c-akt;Publishing;Pyruvate;Reactive Oxygen Species;receptor;Receptor Signaling;Regimen;Resolution;response;Sampling;Services;Signal Transduction;Specificity;stable isotope;Synapses;TBI treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;Transgenic Mice;Traumatic Brain Injury;Treatment Efficacy;treatment optimization;Treatment Protocols;Veterans;War;white matter;Work

PROJECT_TITLE: Targeting mitostasis via activation of mitochondrial biogenesis after TBI


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Hospitalized children suffer harm from medical errors at a rate three times that of adults and depend on clinicians to partner with their families to improve patient safety. Sharing doctors’ notes, which detail their diagnoses, treatment and contingency plans, has prompted adult outpatients to identify safety concerns, over half of which resulted in changes of care. Extending this work to hospitals, the objective of this proposed research is to design an intervention, BedsideNotes, to share doctors’ inpatient notes with families at the bedside to engage them in the care of their hospitalized child and partner with them to prevent harm.

PI_NAMEs: KELLY, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: BedsideNotes: Engaging families to improve pediatric safety

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Exposure to risk factors such as stress or inflammation has been shown to be an important predisposing factor to psychiatric disorders and suicide. However, many individuals exposed to adversity maintain normal psychological functioning, and the factors underlying resistance to the deleterious effects of stress remain unknown. We propose that BDNF functions as a modulator non-neuronal cells responsible for neuroinflammation and kynurenine metabolism in brain, and that it is through this mechanism that BDNF confers resilience to stress.

PI_NAMEs: O'CONNOR, JASON C (contact)

PROJECT_TERMS: Adult;Agonist;Alleles;Animals;antagonist;Anti-Inflammatory Agents;Architecture;Asian;Astrocytes;Attenuated;BDNF gene;Behavior;Behavioral;behavioral response;Brain;brain dysfunction;Brain-Derived Neurotrophic Factor;Caucasians;Cells;Chronic;Chronic stress;Corticosterone;cytokine;Data;depressive behavior;depressive symptoms;Development;Equilibrium;Exhibits;experimental study;Exposure to;Frequencies;frontal lobe;Functional disorder;Funding;Genetic;genetic approach;Genetic Predisposition to Disease;Heterozygote;Hippocampus;Human;Immune;immune activation;Immune system;Impaired cognition;Impairment;Individual;Inflammation;Inflammatory;innovation;insight;Interleukin-10;Intranasal Administration;Knock-in Mouse;Kynurenic Acid;Kynurenine;Major Depressive Disorder;Mediating;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolism;Microglia;military veteran;Modeling;mouse model;Mus;Mutant Strains Mice;neural;neurobiological mechanism;Neurobiology;Neuroglia;neuroinflammation;Neurons;neuroprotection;neurotoxic;novel therapeutic intervention;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phenotype;phospholipase C gamma;Population;pre-clinical;Predisposing Factor;Production;Progress Reports;Prosencephalon;psychologic;Psychological Stress;psychosocial;Psychosocial Stress;Quinolinic Acid;Regulation;Reporting;resilience;Resistance;response;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Stress;stressor;suicidal;Suicide;symptomatology;Synapses;System;systemic inflammatory response;Testing;Therapeutically Targetable;Transgenic Mice;treatment strategy;Tyrosine Phosphorylation;Veterans;Wild Type Mouse

PROJECT_TITLE: Role of Brain-Derived Neurotrophic Factor in Regulating Neuroinflammation in Mental Health


FUNDING_MECHANISM: OTHERS

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: PROJECT NARRATIVE Hypertension and cardiovascular disease are conditions that are devastating and for which there are no curative therapies. Hypertension is the most common risk factor for the development of cardiovascular disease, which is the leading cause of death for United States Veterans. This project seeks to understand how inflammation causes blood vessel and kidney damage in hypertension. The discoveries form this study will lead to new therapeutic targets to combat this escalating health epidemic in the United States Veteran population.

PI_NAMEs: VAN BEUSECUM, JUSTIN PIETER (contact)

PROJECT_TERMS: adduct;Adult;Affect;Age;American;Angiotensin II;Animal Model;Anti-Inflammatory Agents;Atherosclerosis;Award;axl receptor tyrosine kinase;Blood Pressure;blood pressure control;blood pressure reduction;Blood Vessels;Bone Marrow Transplantation;Cardiovascular Diseases;Cause of Death;CD14 gene;cell growth;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Kidney Failure;combat;curative treatments;cytokine;Cytometry;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Endothelial Cells;Endothelium;Epidemic;Essential Hypertension;Experimental Models;exposed human population;Flow Cytometry;Genetic;genetic predictors;Genetic Techniques;Growth;Guidelines;Health;Heart failure;Human;human subject;Hypertension;hypertensive;immune activation;improved;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Kidney;Lead;Ligands;Light;Malignant Neoplasms;Mechanics;Mediating;Methods;military veteran;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;new therapeutic target;Newly Diagnosed;normotensive;novel;novel therapeutics;Organ;Oxidants;Oxidative Stress;Pathogenesis;pharmacologic;Physiological;Play;prevent;Production;Publishing;Reactive Oxygen Species;receptor;renal damage;response;Risk Factors;RNA;Role;sialic acid binding Ig-like lectin;Signal Transduction;Stimulus;Stretching;Stroke;Surface;T-Cell Proliferation;Testing;therapy outcome;translational approach;United States;Veterans

PROJECT_TITLE: A Role of GAS6/Axl Signaling in the Development of Essential Hypertension


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: QUEENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

ORG_STATE: NY

PHR: Speech perception, how one hears speech sound sequences and associated stress patterns, is specific for native speakers of a language. Understanding how the brain transforms physical signals of speech to be specific for native language speakers is critical because this process is fundamental to language comprehension and has translational significance for individuals with phonological processing impairments.

PI_NAMEs: WAGNER, MONICA  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: Identifying acoustic-level and language-specific sensory processing mechanisms


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: To ensure the relevance and high quality of NIGMS research, it is essential that senior scientists are satisfied with, and thriving in, their careers and their future, and are an adequate representation of our society according to gender, race/ethnicity, economic, and cultural background. If our leaders and role models are diverse, we stand to benefit from enrichment of the pool of future investigators, broader perspective in research agenda prioritization, greater success in recruiting diverse research participants, and ultimately enhanced ability to reduce health disparities. By providing intensive training to overcome the final transition barrier to attaining science leadership, we will support the goal of NIGMS and of NIH to achieve sustainable transformation in scientific workforce diversity at all levels, including the most senior one.

PI_NAMEs: DAVIDSON, KARINA W. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Acceleration;Area;Award;career;career development;career networking;cohort;Collaborations;Committee Membership;Communities;comparison control;Control Groups;critical period;Cultural Backgrounds;Data;Development;Development Plans;Economics;Education;Educational Activities;Educational Models;Elements;Eligibility Determination;Enrollment;Ensure;Ethics;Ethnic Origin;Evaluation;evidence base;experience;Faculty;falls;Funding;Future;Future Generations;Gender;Goals;Grant;health disparity;Hearing;improved;indexing;Individual;Industry;innovation;Institution;Job Satisfaction;Journals;Leadership;Learning;Measurable;Mentors;Mentorship;Methods;mid-career faculty;Minority;Mission;Morale;National Institute of General Medical Sciences;next generation;open data;Operations Research;optimism;Organizational Culture;Outcome;Participant;Policies;Policy Maker;Population Heterogeneity;Positioning Attribute;primary outcome;Principal Investigator;Problem Solving;Process;Productivity;professor;Program Sustainability;programs;public engagement with science;Public Health;Publications;Qualifying;Race;Random Allocation;Randomized;recruit;Reduce health disparities;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Rewards;role model;satisfaction;Science;Scientist;Selection Bias;senior faculty;Senior Scientist;skill acquisition;skills;Societies;Structure;success;summer institute;Surveys;synergism;Testing;Time;Training;training opportunity;Training Programs;Underrepresented Populations;United States National Institutes of Health;Woman

PROJECT_TITLE: MAVEN: Developing Diverse Senior Scientists Leaders


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Neurosciences;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Glioma has been associated with a number of infections. We will examine antigen reactivity to all infections previously linked with glioma to assess the risk and survival associated with each of these infections and groups of co-infections. We will then sequence an area of the genome that controls immune response to determine which genetic alterations interact with infections, and how infections and genetics together alter risk and survival of glioma.

PI_NAMEs: FRANCIS, STEPHEN STARKO (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: 19q;Adult Glioma;Affect;Alleles;Amino Acid Motifs;Amino Acid Sequence;Amino Acids;Antibody Response;Antigen Presentation;Antigenic Variation;Antigens;Area;Binding;Biological Assay;BK Virus;case control;Cells;Clinical Data;co-infection;Cytomegalovirus;Data;Detection;Development;epidemiologic data;epidemiology study;Etiology;Foundations;Genes;Genetic;genetic architecture;Genetic Polymorphism;Genetic Variation;Genome;Germ Lines;Glioma;Gliomagenesis;Haplotypes;Herpesviridae;Herpesvirus 1;Herpesvirus Type 3;HHV-6A;Histocompatibility Antigens Class I;HLA Antigens;Human;Human Herpesvirus 4;Human Herpesvirus 7;Immune response;Immunogenomics;improved outcome;Individual;Infection;Infectious Agent;innovation;interest;International;Intervention;Link;Malignant neoplasm of brain;Malignant Neoplasms;Manuscripts;Maps;Measurement;Measures;Mediating;Mediation;member;Meta-Analysis;Modeling;modifiable risk;Mutate;Mutation;nanopore;novel therapeutics;Nucleotides;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Peptides;Play;Polyomaviridae;Polyomavirus;predictive modeling;Predisposition;Prevention;Prognosis;prognostic;Proteins;response;Risk;Risk Assessment;Risk Factors;Role;Sampling;Serology;Serology test;Serum;Simian virus 40;Simplexvirus;survival outcome;synergism;Technology;Testing;Therapeutic;Time;Viral;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: Discovering Infection-mediated Pathways of Glioma Etiology and Prognosis by Leveraging Multiplex Serology and Immunogenomics

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Complementary and Integrative Health;Disability Research;Mental Health;Neurosciences;Pain Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Public Health Relevance: Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients’ suffering, making it a critical area of empirical investigation.

PI_NAMEs: NELSON, SARAH MARY (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: abuse neglect;Acute;Adult;adverse childhood events;Affect;Age;allostatic load;Anxiety;Area;Autonomic nervous system;Award;Blood Pressure;Body mass index;Boston;Brain;Cardiovascular system;career;central sensitization;Child;Childhood;chronic pain;chronic painful condition;Chronic stress;chronic widespread pain;Clinical;Clinical Trials;Clinical Trials Design;Code;Communities;Complement;Data;Data Analytics;dehydroepiandrosterone;Development;disability;Emotional Stress;Environment;Ethnic Origin;Evaluation;Exhibits;experience;Exposure to;follow-up;Foundations;functional disability;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Grant;health care service utilization;Health Status;Heart Rate;Hippocampus;Home environment;Hospitals;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;improved;Investigation;Lipids;longitudinal design;Longitudinal Studies;Maintenance;Measurement;Measures;Meditation;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentorship;Mind-Body Intervention;mindfulness-based stress reduction;Modeling;neglect;Nervous System;neurobiological mechanism;Neurobiology;neuroimaging;Neurologic;Neurologic Dysfunctions;Neurosecretory Systems;Nonpharmacologic Therapy;Odds Ratio;Pain;Pain Clinics;Pain management;pain outcome;pain perception;pain reduction;pain-related disability;Participant;Patients;Pediatric Hospitals;physical impairment;Physiological;Population;primary outcome;programs;psychologic;psychosocial;Public Health;public health relevance;Race;Recording of previous events;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;research study;response;Rest;Risk;Risk Factors;Role;Salivary;Schedule;secondary outcome;sex;Sleep;Stress;stress reduction;Stress Tests;Stressful Event;Structure;Sum;System;Techniques;Testing;Time;Training;treatment optimization;treatment services;Violence;Waist-Hip Ratio;Well Child Visits;Work;Youth

PROJECT_TITLE: Neurobiological Mechanisms of Stress in Youth with Chronic Widespread Pain


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Nutrition;Rare Diseases;Tuberculosis

ORG_CITY: LITTLE ROCK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Diabetes is one of the most serious risk factors for of tuberculosis (TB). The lack of understanding of the underlying mechanism of TB-diabetes comorbidity significantly hinders the control of TB pandemic. This proposal seeks to delineate how diabetes promotes the pathogenesis of TB by interrogating the role of lung macrophage metabolism in TB-diabetes comorbidity, which may be exploited for the development of novel therapeutics.

PI_NAMEs: HUANG, LU  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Address;Agreement;Alveolar Macrophages;ATAC-seq;bacterial fitness;Bone Marrow;Cell Energetics;cell type;Cells;Cholesterol;Chromatin;Chronic;Communicable Diseases;comorbidity;Consumption;Country;Cues;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Environment;Epigenetic Process;Exhibits;exposed human population;Exposure to;extracellular;fatty acid oxidation;Fatty Acids;Gene Expression Profile;Genetic Transcription;Genomics;Genus Hippocampus;Glucose;glycemic control;Glycolysis;Growth;Heterogeneity;Hyperglycemia;Immune response;immunoregulation;Impairment;In Vitro;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;interstitial;Knowledge;Lead;Link;Lung;Lymphocyte Function;Macrophage;Metabolic;Metabolic Diseases;Metabolism;Microbiology;Molecular;Mus;Mycobacterium tuberculosis;non-diabetic;novel;novel therapeutic intervention;novel therapeutics;Nutrient;pandemic disease;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patient risk;Patients;permissiveness;Phagocytosis;Phenotype;Play;Predisposition;Prevention;Public Health;pulmonary function;receptor;Reporter;Reporting;response;Risk Factors;Role;single-cell RNA sequencing;Streptozocin;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;Translational Repression;Tuberculosis;tuberculosis treatment;virtual;Work

PROJECT_TITLE: Macrophage metabolism in diabetes and tuberculosis comorbidity

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: PROJECT NARRATIVE Despite the availability of screening tools that can prevent cervical cancer, Black women are burdened by high cervical cancer incidence and mortality. This project seeks to enhance cervical cancer screening among Black women, African Americans and sub-Saharan African immigrants, by tailoring and pilot testing an evidence-based intervention incorporating HPV self-sampling and peer-delivered education to promote cervical cancer screening.

PI_NAMEs: ADEGBOYEGA, ADEBOLA O (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: access disparities;Address;Africa South of the Sahara;African;African American;African American population;African American Women;aged;anti-cancer research;Awareness;behavior change;behavior influence;Behavior Therapy;Belief;black men;Black Populations;black subgroup;black women;Cancer Burden;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;career;career development;Central Asia;Cervical;Cervical Cancer Screening;Clinic Visits;Clinical Trials Design;Collection;Consent;cost;Cross-Sectional Studies;Data;Death Rate;detection method;Developing Countries;Development;Development Plans;Diagnosis;Disparate;Disparity;Education;Emotional;Environment;ethnic disparity;evidence base;Evidence based intervention;experience;Extramural Activities;Frequencies;Fright;Funding;Future;Geographic Locations;Goals;Gynecologic;Health;Health behavior;health belief;health care availability;Health education;health knowledge;Health Promotion;Healthcare Systems;high risk;high risk population;Human papilloma virus infection;Human Papillomavirus;Immigrant;Incidence;Individual;innovation;Intervention;intervention effect;Intervention Studies;K-Series Research Career Programs;Kentucky;Knowledge;Lavage;Lesion;Literature;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentored Research Scientist Development Award;Mentors;Methods;Minority;Minority Women;Modality;Modeling;mortality;Not Hispanic or Latino;Outcome Measure;Pattern;peer;Physicians;pilot test;poor health outcome;Population;Population Heterogeneity;Population Study;prevent;Preventative vaccination;Prevention;Privatization;programs;Quality of Care;Quasi-experiment;racial disparity;racial population;randomized, clinical trials;recruit;Research;Research Personnel;research study;Resources;Role;Sampling;satisfaction;screening;Screening for cancer;screening participation;Screening procedure;Self Efficacy;Sensitivity and Specificity;skills;social;social cognitive theory;South America;Structure;Subgroup;Swab;Testing;Training;Treatment Efficacy;underserved minority;Underserved Population;United States;Universities;Visit;Vulnerable Populations;White Women;willingness;Woman;Women's mortality

PROJECT_TITLE: Promoting Cervical Cancer Screening among African American and Sub-Saharan African Immigrant women

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ORG_CITY: Newark

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Helminth parasites infect approximately 2 billion people worldwide and represent a significant public health and economic challenge. While multiple studies have revealed the mechanisms that promote helminth-induced inflammation, the factors that restrict these responses to prevent unwanted tissue damage remain poorly defined. This proposal will investigate the existence of a neuropeptide-mediated rheostat that functions to properly regulate helminth-induced inflammation and promote optimal outcomes.

PI_NAMEs: ARTIS, DAVID ;SIRACUSA, MARK CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Basophils;Binding;Body Temperature;Bombesin;Bombesin Receptor;Cell Culture System;cell growth;Cell Separation;Cells;Central Nervous System;Characteristics;Child;cholinergic neuron;Chronic;combat;Complex;cytokine;Data;Development;Economics;Eosinophilia;Equilibrium;Event;Exhibits;Family;Family member;Gastrointestinal tract structure;Generations;Genetic Transcription;Glucose;Growth;helminth infection;Helminths;Helper-Inducer T-Lymphocyte;Hematopoietic;Hookworms;Human;Immune;Immune response;Immune system;Immunity;Immunologic Receptors;immunopathology;In Vitro;in vivo;Individual;Infection;Infection prevention;Inflammation;Inflammatory Response;inhibitor;insight;Knowledge;Ligands;LoxP-flanked allele;Lung;Lymphocyte;Lymphoid Cell;Malnutrition;Mediating;mouse model;Mucous body substance;Mus;Muscle Contraction;Nervous System;neuromedin B;Neuromedin U;Neurons;Neuropeptide Receptor;Neuropeptides;Nippostrongylus;novel;novel therapeutic intervention;Outcome;Parasites;Pathology;Pathway interactions;Patients;Pattern;Peptides;Persons;Population;Prevalence;prevent;Production;Public Health;Publishing;pulmonary function;Pulmonary Pathology;receptor;receptor expression;Receptor Signaling;Recombinants;Regulation;Reporting;response;Risk;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Testing;Therapeutic Uses;Tissues

PROJECT_TITLE: Neuropeptide-mediated regulation of antihelminth immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Palliative Care;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The REHAB-HFpEF trial will determine whether a novel physical rehabilitation intervention will improve the primary outcome of combined all-cause rehospitalizations and mortality and the secondary outcome of major mobility disability during 6-month follow-up in patients hospitalized for heart failure and preserved ejection fraction (HFpEF), which is nearly unique to older persons, particularly women and Black persons, and for which there are few treatment options.

PI_NAMEs: KITZMAN, DALANE W (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accident and Emergency department;Acute;Address;adjudication;Affect;Age;Attention;attentional control;Black Populations;Blood Banks;Blood specimen;Caregivers;Cessation of life;Clinic Visits;Clinical;clinical care;clinical center;Cognition;Congestive Heart Failure;cost effectiveness;cost estimate;Data;Disproportionately impacts women;Dissemination and Implementation;Educational workshop;EFRAC;Elderly;Enrollment;Ensure;Event;Evidence based treatment;experience;falls;follow-up;frailty;Funding;Future;Geography;Guidelines;Health Care Costs;health care service utilization;health related quality of life;Health system;Heart failure;heart preservation;high risk;high risk population;Home;hospital readmission;Hospitalization;Impairment;improved;innovation;Institutionalization;Intervention;intervention effect;intervention program;Leadership;Medical;Medicare claim;Mental Depression;meter;Mobility disability;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;novel;older adult;older patient;Older Population;older women;Outcome;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;phase II trial;Phenotype;Physical activity;physical conditioning;Physical Function;Physical Performance;Physical Rehabilitation;physically handicapped;preservation;Prevalence;primary endpoint;primary outcome;Randomized;Recommendation;Reporting;Research Personnel;Resources;response;secondary endpoint;secondary outcome;single-blind trial;Structure;Subgroup;Syndrome;Testing;Time;treatment as usual;trend;Underserved Population;Vulnerable Populations;Walking;Woman

PROJECT_TITLE: Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Cohesin generates and maintains the chromatin loops that serve as a fundamental unit of 3D genome organization. Cohesin is frequently mutated in GBM, the most common and deadly tumor of the brain, with STAG2 as its most frequently mutated subunit. This grant proposes to identify the mechanistic connection between STAG2 mutations and alterations in 3D genome organization in GBM cells and tumors, providing a long-sought molecular mechanism for cohesin-mediated tumor suppression, with the goal of defining how cohesin can be targeted for therapeutic purposes in GBM.

PI_NAMEs: JIN, FULAI ;WALDMAN, TODD A (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Alleles;Auxins;Binding;Bioinformatics;bioinformatics pipeline;Biological;Biology;Brain Neoplasms;Cancer Biology;cancer type;Cells;ChIP-seq;Chromatin;Chromatin Loop;Classification;cohesin;cohesion;Complex;Data;Data Analytics;Development;DNA Repair;efficacy evaluation;Enhancers;epigenomics;Ewings sarcoma;experimental study;EZH2 gene;FDA approved;Gene Expression;Gene Mutation;gene repression;Gene Silencing;Genes;Genome;Glioblastoma;Goals;Grant;Hi-C;Homeobox Genes;In Vitro;in vivo;Individual;inhibitor;Knowledge;Link;Location;Maintenance;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Modeling;Molecular;multidisciplinary;mutant;Mutate;Mutation;Myeloid Leukemia;Neoplastic Cell Transformation;novel therapeutic intervention;Pathogenesis;Play;Polycomb;PRC1 Protein;Primary Brain Neoplasms;Primary Neoplasm;Process;promoter;Repression;Research;Research Personnel;Role;Signal Transduction;Sister Chromatid;System;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic evaluation;therapeutic target;Transcriptional Regulation;transcriptome sequencing;tumor;Tumor Suppression;Tumor Suppressor Genes;Tumor-Derived;Xenograft procedure

PROJECT_TITLE: STAG2 mutations and 3D genome organization in glioblastoma multiforme

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Brain Slug protein controls body weight and metabolism. This project will test a hypothesis that EZH2 and EED, two proteins well-studies for their roles in cancer development, mediate Slug’s pro-obesity action. This project will test the possibility that EZH2 and EED inhibitors, anti-cancer drugs, may be repurposed to treat obesity, type 2 diabetes, and fatty liver disease.

PI_NAMEs: RUI, LIANGYOU  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adult;Affect;Antineoplastic Agents;Area;Binding;Body fat;Body Weight;Brain;Brain-Derived Neurotrophic Factor;C-terminal;cancer therapy;Catalytic Domain;cell fate specification;cell motility;Cell Physiology;Chemicals;Complex;Data;Deposition;Development;Diet;diet-induced obesity;Disease;DNA Binding Domain;Electrophysiology (science);Embryo;energy balance;Energy Metabolism;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Epithelium;EZH2 gene;Fatty Liver;fatty liver disease;feeding;gene repression;Genes;HDAC1 gene;Health;Hepatocyte;High Fat Diet;histone methylation;Histones;Homeostasis;Human;Hypothalamic structure;Impairment;inhibitor;Injections;KDM1A gene;Knock-out;Knockout Mice;Leptin;leptin receptor;Leptin resistance;Link;Lysine;Maintenance;Malignant Neoplasms;Mediating;Mesenchymal;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Methylation;Modification;Mus;mutant;N-terminal;Neoplasm Metastasis;neural circuit;Neural Pathways;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 2;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;Obesity;obesity development;obesogenic;Outcome;overexpression;pharmacologic;Phenotype;Polycomb;promoter;Property;Proteins;receptor;receptor expression;recruit;Regulation;Reporting;Research;Resistance;Role;Shapes;Signal Transduction;slug;Slug protein;Testing;Therapeutic;transcription factor;Transcription Repressor;Up-Regulation;Variant

PROJECT_TITLE: The role of hypothalamic Slug in the regulation of leptin sensitivity, energy balance, and body weight

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Methamphetamine;Pulmonary Hypertension;Rare Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Methamphetamine and other stimulant abuse have been increasing across the United States and the world with several known complications which can result. This grant will study the relationship between methamphetamine use and the presence of pulmonary arterial hypertension in a case-control epidemiologic study.

PI_NAMEs: KAWUT, STEVEN M (contact);ZAMANIAN, ROHAM

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adult;Affect;Agonist;Alleles;Biological;Carboxylesterase 1;case control;Case/Control Studies;Cell Death;cell injury;Cells;Cessation of life;Chronic;Clinical;clinical predictors;Clinical Trials;comorbidity;Complication;Data;Dexfenfluramine;Disease;Emergency department visit;Endothelial Cells;Endothelium;Epidemic;Epidemiology;epidemiology study;Esters;Exercise;Fenfluramine;Genetic;genetic variant;Goals;Grant;Heritability;high risk;Hospitalization;Human;improved;improved outcome;infancy;Injury;insight;Knowledge;Link;Lung;lung microvascular endothelial cells;Lung Transplantation;Metabolic;Metabolism;Methamphetamine;methamphetamine use;methamphetamine user;Midwestern United States;Minor;mitochondrial dysfunction;Modification;Multicenter Studies;North America;novel;novel therapeutic intervention;Outcome;Oxidative Stress;Patient observation;patient oriented research;Patients;personalized medicine;Persons;Pharmaceutical Preparations;preclinical study;premature;Prevalence;primary pulmonary hypertension;Proliferating;Prospective, cohort study;Proteomics;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;receptor;Recording of previous events;Registries;Reporting;research study;Right Ventricular Dysfunction;right ventricular failure;Risk;Risk Estimate;Risk Factors;risk stratification;Route;screening guidelines;side effect;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Socioeconomic Status;Stimulant;stimulant abuse;Toxin;treatment strategy;United States;vascular bed;virtual

PROJECT_TITLE: Case-Control Study of Methamphetamine in Pulmonary Arterial Hypertension

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Unlike the static, double-helical structure of DNA depicted in textbooks, sculpture, and art, the DNA of living cells is dynamic—winding and unwinding to allow its duplication and repair. Many antibiotic and anticancer drugs target enzymes that bind to DNA only in underwound or overwound states, yet the impact of DNA winding has been largely ignored because the tools to address it properly in experiments did not exist. To remedy this, we invented methods to create DNA as it exists in living cells and propose to study how these drugs work and find new drugs for infections, cancer, and neurological diseases.

PI_NAMEs: ZECHIEDRICH, LYNN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Affect;analytical ultracentrifugation;Antibiotics;antimicrobial;Antineoplastic Agents;Binding;Biochemical;Biological Assay;Biophysics;Cell Physiology;Cells;Chromatin Loop;clinical application;Coupled;Cryoelectron Microscopy;Data;design and construction;DNA;DNA biosynthesis;DNA Structure;DNA Topoisomerases;drug action;drug efficacy;Drug Interactions;Drug Targeting;Engineering;Enzymes;experimental study;Fluorescence;Frequencies;fundamental research;Gene Delivery;gene therapy;Gene Transduction Agent;Genetic Transcription;Genomic Instability;Gold;Human;human disease;Imaging Device;improved;in vivo;Infection;inhibitor;innovation;insight;invention;Knowledge acquisition;Libraries;Malignant Neoplasms;Methods;Molecular Conformation;Monosaccharides;nanoparticle;Nervous System Disorder;novel;novel therapeutics;Pharmaceutical Preparations;Physiological;Property;repaired;Research;screening;Sculpture;Shapes;Structure;Superhelical DNA;targeted agent;Techniques;Textbooks;Therapeutic;therapeutic target;three dimensional structure;Time;tomography;tool;Topoisomerase;uptake;Vision;Work

PROJECT_TITLE: Harnessing Supercoiling to Regulate DNA Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Neurosciences;Nutrition;Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Adipose tissue is increasingly recognized for its impact on energy expenditure, glucose and fat metabolism and is under sympathetic control. This brain-to-fat circuit has not been explored in its full extent, and specifically pre-and postganglionic neurons innervating distinct brown and white adipose tissue depots are largely unexplored. Here we propose to use the modern toolbox of neuron-specific manipulation to directly stimulate and inhibit postganglionic neurons for select adipose tissues and their interaction in metabolic control. This project is using a new brain-to-fat experimental approach that aims to integrate findings from brain circuits and adipose tissue research to generate a circuit model that is able to predict metabolic adaptations in diverse physiological states.

PI_NAMEs: MUENZBERG-GRUENING, HEIKE  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Adipose tissue;Agonist;Alzheimer's Disease;antagonist;axon growth;blood glucose regulation;Brain;Brain Diseases;Brain Stem;Brown Fat;Central Nervous System;cold temperature;Communication;designer receptors exclusively activated by designer drugs;Diabetes Mellitus;Energy Metabolism;Fasting;Fatty acid glycerol esters;feeding;gamma-Aminobutyric Acid;Genetic;glucose metabolism;Glutamates;Hypothalamic structure;Learning;Leptin;leptin receptor;lipid metabolism;LoxP-flanked allele;Membrane Potentials;Memory impairment;Mental Depression;Mental disorders;Metabolic;Metabolic Control;Metabolic Diseases;Modeling;Modernization;Monitor;Motor Neurons;Mus;Nature;Nerve;neural circuit;Neurodegenerative Disorders;neurogenesis;Neurons;novel;Nutritional status;Obesity;Optics;Organ;painful neuropathy;Pathway interactions;Peripheral;Peripheral Nervous System;Physiological;Population;Presynaptic Terminals;Production;Regulation;Reporter;Research;response;Role;Sensory;Signal Transduction;Site;Solvents;Spinal Cord;Substance abuse problem;Sympathetic Ganglia;Synapses;Techniques;Temperature;Temperature Sense;Testing;Three-Dimensional Imaging;Time;Tracer;Viral;Visualization;Work

PROJECT_TITLE: Metabolic Changes: Connecting temperature sensing neurons to sympathetic adipose tissue stimulation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Hematology;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Women's Health Research

ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF GHANA

PHR: NARRATIVE The blood transfusion service is a health facility aimed at ensuring the availability of a sustainable supply of safe blood and blood products to hospitals for use in patients who require transfusion as part of their clinical management. This aim is achieved through the altruism of voluntary unpaid and family replacement blood donors. The World Health Organization estimates that blood donation by 1% of the population is generally the minimum needed to meet a nation's most basic requirements for blood. Blood donors are healthy subjects usually between the ages of 17 to 60 although the upper and lower limit vary from country to country who donate their whole blood or blood components. The lower limit is to take account of the national legal requirements for consent, the increased risk of vasovagal reactions in younger donors, and the increased iron requirements of adolescents and young menstruating females, and upper age limit is so set because of increase in various medical conditions with age especially cardiovascular diseases making donations more hazardous. The voluntary unpaid blood donor is the blood donor who gives blood or blood products of their own free will and will not receive money or any form of payment while the regular voluntary blood donor has donated at least 3 times and continues to donate at least once a year. A stringent screening and selection process aimed at assessing the suitability of prospective donors is therefore essential in ensuring the safety and sufficiency of the blood supply; safeguarding the health of the recipients of transfusion as well as that of the donors; and at the same time ensuring that suitable donors are not unnecessarily deferred. Frequent and unnecessary temporary deferral of blood donors lead to loss of potential blood donors some of whom may be reluctant to return for future donations. It is apparent that a lot of attention is given to ensure the safety of the blood and blood products to the recipient but less attention is accorded the blood donors who donate the essential and scarce raw material. With continuous depletion of iron stores from repeat donations and inadequate replacement, the body adapts to reduced concentrations of iron or develops iron deficiency and anaemia. Greater frequency of blood donation is accompanied by lower iron status. Inadequate and irregular blood supply play a cardinal role in the high mortality rates in obstetric haemorrhage and other causes of severe anaemia in Ghana. Though significant efforts were made to achieve the 5th millennium development goal (MDG5), the targets were missed due to the impact of major direct causes of maternal death such as haemorrhage, hypertensive diseases and abortion complications. Comparing the maternal mortality trends across Ghana, haemorrhage as a cause of maternal death has dropped to second place in most urban centers and teaching hospitals where haemorrhage is now second leading cause of maternal death. Maternal mortality surveys in district hospitals and other community health facilities show very high rates and are predominantly due to haemorrhage. Our long-term goal is to provide adequate safe blood in Ghana by establishing a new paradigm of blood collection in the country focused on a community-based volunteer system and nutritional donor enrichment.

PI_NAMEs: ASAMOAH-AKUOKO, LUCY ;DEI-ADOMAKOH, YVONNE  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: abortion;Acute;Adolescent;Africa South of the Sahara;Age;Altruism;Anemia;animation;Attention;Awareness;Back;base;Behavioral;Blood;Blood Donations;Blood donor;blood product;Blood Transfusion;Cardiovascular Diseases;Caring;Chronic;Clinical;Clinical Management;Collection;commune;Communication;Communities;community based evaluation;Community Health;Community Hospitals;community organizations;Consent;Country;Death Rate;design;Development;Discipline of obstetrics;District Hospitals;Drama;Drops;Education;efficacy evaluation;Emergency Situation;Ensure;Family;Female;Free Will;Frequencies;Fright;Future;Ghana;Goals;Health;Health care facility;Hematologist;Hemorrhage;Hospitals;Hypertension;improved;Individual;Intervention;Iron;iron deficiency;Iron deficiency anemia;iron supplementation;Knowledge;Lead;Leadership;Legal;Maternal Mortality;Medical;Menstruation;Methods;Modeling;Motivation;multidisciplinary;nutrition;Nutritional;nutritional supplementation;Outcome Measure;Patients;payment;Play;Policies;Population;primary outcome;Process;prospective;Public Health;Reaction;Recommendation;recruit;Recurrence;response;Risk;Role;Safety;screening;Secure;Services;Sickle Cell Anemia;sociologist;Source;Specialist;Supplementation;Surveys;System;Teaching Hospitals;Testing;Time;Transfusion;trend;Vascular blood supply;Vasovagal;volunteer;Whole Blood;World Health Organization

PROJECT_TITLE: Development and evaluation of community-based approaches and donor care intervention models for improving availability and safety of blood for the management of severe anemia in Ghana


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Mental Health;Mental Illness;Physical Activity;Prevention;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: PROJECT NARRATIVE We propose to optimize an intervention package to improve lifestyle physical activity among older persons living with HIV. We will test the potential efficacy and feasibility of three intervention components, individual and combined, using a factorial experiment, and use the results to determine which components should go into a comprehensive intervention package to be tested in a future clinical trial. This proposal addresses an important need among older persons living with HIV facing excess clinical risk from co-morbidities of aging including cardiovascular disease, depression and frailty.

PI_NAMEs: BAKER, JASON V;UEBELACKER, LISA A (contact)

PROJECT_TERMS: Accelerometer;Address;Affect;Age;Aging;antiretroviral therapy;Behavior Therapy;Behavioral;Behavioral Research;brief advice;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Chronic;chronic pain;Classification;clinical risk;Clinical Trials;Cognitive;Cognitive Therapy;comorbidity;Conduct Clinical Trials;Coping Skills;Counseling;Data;design;Development;Disease;efficacy evaluation;efficacy validation;Enrollment;Evaluation;Exercise;exercise intervention;experience;experimental study;Fatigue;fitbit;frailty;Friends;Future;Goals;Guidelines;Health Benefit;healthspan;High Prevalence;HIV;human old age (65+);improved;Individual;Intervention;Interview;Life;Life Style;lifestyle factors;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;multidisciplinary;multiphase optimization strategy;older adult;Older Population;Outcome;Pain;Participant;Persons;Phase;Phenotype;Physical activity;physical conditioning;Preparation;Primary Care;primary outcome;Privatization;programs;Public Health;Quality of life;Recommendation;recruit;Refractory;Research;Risk;Risk Factors;secondary outcome;social;Social support;Specific qualifier value;Testing;theories;therapy development;Walking

PROJECT_TITLE: Optimization of a behavioral intervention to increase physical activity in older adults living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-T(04)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Physical Activity;Physical Rehabilitation;Rehabilitation;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: BLOOMER HEALTH TECH INC

PHR: PROJECT NARRATIVE Cardiac rehabilitation is strongly recommended following a variety of cardiovascular disease complications for evidence of reduced mortality, morbidity, and increased quality of life, but it is underutilized, especially in women, where barriers to increase adherence to cardiac rehabilitation are different for men and women. Bloomer Tech is advancing development of the Bloomer Augmented Garment (AG), a cardiac biomarker-based remote- monitoring platform designed for optimal fit and performance in women. Here, Bloomer Tech will complete a clinical trial to demonstrate that the Bloomer AG platform increases adherence to cardiac rehabilitation over the standard of care toward improved health outcomes and reduced healthcare disparities in women.

PI_NAMEs: CHONG, ALICIA  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Achievement;Activities of Daily Living;Address;Adherence;adherence rate;Adhesives;Adoption;Adult women;Advanced Development;Adverse event;American;American Heart Association;analog;Biological Markers;Cardiac;Cardiac rehabilitation;Cardiology;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cause of Death;Cessation of life;Clinic;Clinical;clinical research site;Clinical Trials;college;commercialization;comparison control;Computer software;Continuity of Patient Care;Control Groups;design;Device Designs;Devices;Digital biomarker;disability;disparities in women;Electrocardiogram;Electrodes;Eligibility Determination;Ensure;Excision;Exercise;exercise prescription;exercise regimen;experience;Face;Family Caregiver;Female;Florida;Frequencies;Funding;Goals;group intervention;Health;health care disparity;health disparities in women;Health system;Heart Diseases;heart rate monitor;Home;Hospitalization;improved;indexing;innovation;Intervention;Lead;Life;Location;Mammary Gland Parenchyma;manufacture;Measures;Medical;Medical center;men;mobile application;Monitor;monitoring device;Morbidity - disease rate;mortality;Motivation;Movement;open label;Outcome;Participant;patient population;Patients;Perception;Performance;Phase;Posture;primary endpoint;programs;prospective;Provider;provider adoption;Quality of life;randomized, clinical trials;Recommendation;remote monitoring;remote sensing;Reporting;Reproducibility;Research;Role;Safety;secondary endpoint;Secure;sensor;Sex Differences;Shapes;Signal Transduction;Skin Temperature;smart watch;standard of care;success;Supervision;Surveys;Testing;Textiles;Transportation;treatment arm;Universities;usability;Validation;Visual;wearable device;wearable sensor technology;Woman;women's clinical trial;Women's mortality;women's outcomes;Wrist

PROJECT_TITLE: Bloomer Augmented Garment Platform-Barrier Removal for women in cArdiac rehab (BRA)


ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE In this proposal we aim to develop improved algorithms for the estimation of ESKD risk in Type 2 diabetes (T2D) by adding newly identified biomarkers to established clinical predictors such as GFR and albuminuria. A more precise estimation of ESKD risk would be beneficial in several respects: it would improve the cost-benefit ratio of currently available ESKD-preventive therapies, it would help optimize clinical care by allowing referral of patients to nephrologists early in the trajectory to ESKD, and it would increase the efficiency of clinical trials aimed at testing new therapies by facilitating the enrollment of patients with a high likelihood of experiencing significant kidney function loss within the limited timeframe of the trial.

PI_NAMEs: KROLEWSKI, ANDRZEJ S (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Age;Albuminuria;Algorithms;Antibodies;Biological Assay;Biological Markers;biomarker identification;biomarker panel;candidate marker;cardiovascular risk factor;Characteristics;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinic;Clinical;clinical care;clinical predictors;Clinical Trials;cohort;Cohort Studies;Costs and Benefits;Country;Data;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetic patient;Discrimination;disorder risk;End stage renal failure;experience;follow-up;Follow-Up Studies;Goals;high risk;Immunoassay;Impairment;improved;Individual;Intervention;Kidney;Kidney Diseases;Laboratories;loss of function;Measures;Modeling;Molecular;multiplex assay;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Online Systems;Outcome;Participant;participant enrollment;Patient Care;patient stratification;Patients;Performance;prediction algorithm;Prevalence;prevent;Preventive therapy;primary outcome;prognostic algorithm;Prognostic Marker;prognostic model;prognostic performance;prognostic tool;progression risk;Proteins;Proteomics;Renal function;Research;Research Personnel;Risk;risk prediction;risk prediction model;Sampling;secondary outcome;Serum;Serum Proteins;sex;Specificity;Specimen;success;Techniques;Testing;Time;United States National Institutes of Health

PROJECT_TITLE: Development of Prognostic Algorithms to Identify Subjects at High Risk of ESKD in Type 2 Diabetes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Proteins outside of the cell must traverse the complex, chemically-diverse, confining environment of the extracellular matrix to carry out their biological function. Our studies seek to identify and characterize how proteins function within this matrix using high-resolution optical microscopy and analysis methods. Our results can be applied broadly to therapeutic delivery, tissue engineering, and understanding of disease development, along with fundamental studies into the biological processes that underlie protein-matrix interactions.

PI_NAMEs: KISLEY, LYDIA  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affect;Area;Biochemical;Biological;Biological Process;Biology;Biophysics;Cells;Chemicals;Complex;Development;Diffusion;Disease;Drug Delivery Systems;Environment;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Goals;imaging modality;Methods;Microscopy;model design;nanoscale;Optics;Property;Protein Dynamics;protein folding;protein function;Proteins;Regulation;Research Personnel;Resolution;Signaling Protein;spatiotemporal;Structure;superresolution imaging;superresolution microscopy;Techniques;temporal measurement;Therapeutic;Time;Tissue Engineering;Tissues;Variant

PROJECT_TITLE: Super-resolution imaging of protein dynamics in the extracellular matrix


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Childhood Obesity;Crohn's Disease;Data Science;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Networking and Information Technology R&D (NITRD);Obesity;Pediatric;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative and Relevance to Public Health  This project aims to develop powerful statistical and computational methods for analysis of human microbiome and metagenomics data. The novel statistical methods are expected to gain more insights into how microbial community stability and other ecological properties can lead to different phenotypes such as childhood obesity, progression of chronic kidney diseases and responses to treatments of inﬂammatory bowel disease. Understanding such microbial dynamics can lead to possible microbiome-based disease prevention and treatment.

PI_NAMEs: LEE, HONGZHE  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Biological;Biological Process;Cardiovascular Diseases;Cataloging;Cells;Charge;Chronic Kidney Failure;Chronic Kidney Insufficiency;cohort;Collaborations;Collection;Communities;Complex;Computational algorithm;computer program;Computer software;computerized tools;Computing Methodologies;Consensus;Crohn's disease;Data;Data Analyses;Data Science;Data Set;Development;Diabetes Mellitus;Disease;Disease Progression;disorder prevention;disorder risk;Documentation;Ecosystem;Evaluation;experimental study;Genes;Genetic Markers;Grant;gut microbiome;Health;High-Throughput Nucleotide Sequencing;host microbiome;Human;Human body;human disease;Human Microbiome;human model;Immune;Inflammatory Bowel Diseases;innovation;insight;interest;Ising model;Link;Malignant Neoplasms;metagenome;metagenomic sequencing;Metagenomics;Methodology;Methods;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome analysis;microbiome research;microbiota;Modeling;Mucous Membrane;Network-based;novel;Obesity;obesity in children;Organism;Outcome;Patients;Pediatric Crohn's disease;Pennsylvania;Performance;Phase;Phenotype;Phylogenetic Analysis;Physicians;Play;Potential Energy;Procedures;Program Efficiency;programs;Property;Public Health;Research;Research Personnel;Ribosomal RNA;Role;Shapes;Shotguns;simulation;Software Tools;Statistical Methods;Statistical Models;Structure;Systems Biology;Taxon;Technology;Time;tool;treatment response;Universities;Work

PROJECT_TITLE: Statistical Methods for Microbiome and Metagenomics

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cancer;Genetics

PHR: Defects in genes that encode chromatin remodelers, including epigenetic “readers, writers and erasers”, occur frequently in many types of cancer. We have discovered that these chromatin remodeler proteins have a second, equally important, function remodeling the cytoskeleton. The goal of this application is to elucidate the repertoire of these dual‐function chromatin‐ cytoskeleton remodelers and understand how defects in genes encoding dual‐function remodelers impact both chromatin and the cytoskeleton, to drive cancer.

PI_NAMEs: WALKER, CHERYL L. (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Adult;anti-cancer research;Award;blind;cancer risk;cancer type;Cell Physiology;Cells;chemical carcinogen;Chromatin;Code;Cytoskeleton;Cytoskeleton Alteration;Data;Defect;design;Development;environmental carcinogenesis;Environmental Carcinogens;Environmental Exposure;Epigenetic Process;epigenome;experimental study;frontier;Genes;Genomic Instability;Goals;Histone Code;insight;Laboratories;Malignant Neoplasms;Methylation;Microtubules;Mitotic spindle;Needles;Neoplasm Metastasis;Play;programs;protein function;Proteins;Reader;Reading;Reporting;Research;Research Personnel;therapy development;Tubulin;Tumor Suppressor Genes;Writing

PROJECT_TITLE: A New Target for Chromatin Remodeler Defects in Cancer


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Surgical technical skills are important to measure accurately and in a cost-effective way as they directly correlate to patient outcomes. Common practice is to employ human raters, either expert or non-expert, yet we lack rigorous scientific understanding of how fundamentally accurate or inaccurate, biased or unbiased, such ratings are. This proposal aims to further this understanding to provide actionable knowledge regarding what improves, hinders, or biases human ratings of surgical skill in three surgical specialties: urology, gynecology, and orthopedics.

PI_NAMEs: KOWALEWSKI, TIMOTHY M (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Adoption;Age;Benchmarking;blind;Blinded;bone;cost;cost effective;Credentialing;Crowding;Data;Discrimination;Docking;Ethnic Origin;Evaluation;Exhibits;experience;Faculty;Female;Foundations;Fracture Fixation;Gender;Goals;Gynecologic Surgical Procedures;Gynecology;Hip Fractures;Human;Hysterectomy;Implant;improved;Investigation;Knowledge;male;Measurement;Measures;medical specialties;Methods;Motion;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Patient-Focused Outcomes;Peer Review;Perception;Performance;Procedures;programs;Prostatectomy;Race;radiological imaging;rate of change;Research;Research Proposals;Residencies;Resources;Rewards;Robotics;Science;Sex Bias;skills;soft tissue;Speed;Structure;Surgeon;surgery outcome;Surgical Specialties;System;Technical Expertise;Testing;Time;Training;unconscious bias;Unconscious State;Urologic Surgical Procedures;Urology;Validation;Visual;web-enabled

PROJECT_TITLE: Scientific Foundations for Assessment of Surgical Technical Skills

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: Black women in the US continue to experience much higher breast cancer mortality rates than any other race/ethnic group in the US, and current knowledge regarding this mortality gap does not adequately explain its magnitude; thus, effective strategies to address the problem remain elusive. We propose to investigate a highly understudied factor – i.e., exposure to an overarching environment of systemic racism, which we hypothesize is biologically embodied in a stress response that alters key immune, metabolic and epigenetic pathways important in breast cancer etiology. Our study will determine whether, and to what extent, exposure to systemic racism alters key biological pathways and helps explain the increased breast cancer mortality risk among Black vs. White women, helping to inform clinical and public health mitigation strategies.

PI_NAMEs: AKINYEMIJU, TOMI F (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;adverse outcome;allostatic load;Area;Biological;biological adaptation to stress;Biological Markers;Black American;Black Populations;Black race;black women;Breast Cancer gene;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;Cancer Etiology;cancer health disparity;Cancer Prognosis;Cessation of life;Chronic;Clinical;clinically relevant;cohort;Cohort Studies;Communities;comorbidity;Crows;Data;data infrastructure;Death Rate;Diagnostic;Disparate;Disparity;DNA Methylation;Dyslipidemias;Environment;Epigenetic Process;epigenome;Estrogen receptor negative;Ethnic Population;Evaluation;experience;Exposure to;Fibrinogen;follow-up;Future;Genes;Genetic;Health;Hyperinsulinism;hypothalamic-pituitary-adrenal axis;IL8 gene;Immune;improved;Incidence;indexing;Inequity;Inflammation;Inflammatory;Institution;Institutional Racism;Interleukin-10;Interleukin-6;Investigation;Knowledge;Laws;Legal;Life Cycle Stages;Link;Literature;Malignant Breast Neoplasm;Measures;Mediating;Metabolic;Metabolic Pathway;Modeling;mortality;mortality disparity;mortality risk;multi-ethnic;neoplasm registry;novel;Outcome;Parents;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Patients;people of color;perceived discrimination;poor health outcome;Prevention strategy;Primary Prevention;Process;Prognosis;Prognostic Marker;prognostic model;prospective;Prospective cohort;Prospective Studies;Psychosocial Stress;Public Health;pyrosequencing;Race;racial discrimination;racial disparity;racial population;Reasons for Geographic And Racial Differences in Stroke;Recording of previous events;Research;residential segregation;Resources;Risk;Risk Factors;Sampling;Socioeconomic Status;Support Groups;Testing;Time;tumor;United States;White Women;Woman

PROJECT_TITLE: Systemic Racism and Biological Embodiment of Risk in Breast Cancer Mortality

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROPOSAL NARRATIVE:  The goal of this project is to elucidate the mechanism(s) by which aggressive-variant PTEN-deficient prostate cancers (PC) are resistant to DNA sensing cGAS/STING pathway activation, and evaluate the therapeutic potential of direct STING agonist/PI3Ki combination therapy in sensitizing this disease to immune checkpoint inhibitors.

PI_NAMEs: PATNAIK, AKASH  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Agonist;androgen independent prostate cancer;anti-cancer;Antibodies;Antitumor Response;Bypass;cancer cell;cancer infiltrating T cells;Cancer Patient;Cells;Clinical;Clinical Research;Clinical Trials;combinatorial;Combined Modality Therapy;Cyclic GMP;Data;derepression;Disease;DNA;DNA Damage;DNA Double Strand Break;extracellular vesicles;Foundations;Gene Activation;Generations;Genetically Engineered Mouse;Goals;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunotherapeutic agent;Infiltration;Knock-out;loss of function;Macrophage;Macrophage Activation;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Modeling;mouse model;multiple omics;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;Nature;neoplastic cell;Nivolumab;PARP inhibition;Pathway interactions;Patients;PIK3CG gene;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Prognosis;programmed cell death protein 1;programs;Prostate;prostate cancer model;PTEN gene;refractory cancer;Research Personnel;Resistance;resistance mechanism;response;Sampling;scavenger receptor;Signal Transduction;Stimulator of Interferon Genes;Stress;subcutaneous;Surface;T cell infiltration;Testing;Therapeutic;therapy outcome;tumor;tumor microenvironment;Tumor-associated macrophages;Variant;vesicular release

PROJECT_TITLE: Targeting the cGAS/STING Pathway to Overcome Resistance to Immune Checkpoint Inhibitors in PTEN-deficient Prostate Cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Metastatic breast cancer, of which hormone receptor-positive breast cancer is the most common, is estimated to affect approximately 150,000 women in the United States; most of these women will die of breast cancer, making it the second leading cause of cancer death among women. This proposal will examine distinct molecular categories of hormone receptor-positive metastatic breast cancer to understand whether different treatments may affect these groups differently. The knowledge gained will lay the groundwork for a personalized approach to therapy for metastatic breast cancer to improve health and lengthen life.

PI_NAMEs: CASWELL-JIN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Affect;Applications Grants;Area;Automobile Driving;Award;Bioinformatics;Biological Assay;Biology;biomarker development;Biopsy;Breast;breast cancer genomics;Cancer Etiology;cancer subtypes;career;career development;Categories;CCND1 gene;CDK4 gene;Cessation of life;Characteristics;Classification;Clinical;Clinical Trials;cohort;Data;Data Set;design;Development;Diagnosis;Disease;Distant Metastasis;DNA Sequence Alteration;effective therapy;ERBB2 gene;Exhibits;FGF19 gene;Fibroblast Growth Factor Receptors;Fluorescent in Situ Hybridization;Frequencies;Genes;genetic variant;Genome;genome sequencing;genome-wide;Genomic approach;Genomics;Goals;Health;high risk;hormone receptor-positive;hormone therapy;improved;improved outcome;In Situ;inhibitor;insight;Institution;instructor;Knowledge;Learning;Length;Life;Ligands;machine learning algorithm;machine learning method;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mentorship;Metastatic breast cancer;Metastatic/Recurrent;Methods;Molecular;Multiomic Data;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Oncologist;overexpression;Participant;Pathway interactions;patient subsets;Patients;personalized approach;personalized therapeutic;Phase Ib Clinical Trial;Plasma;precision oncology;Proteomics;Public Health;Receptor Inhibition;Recurrence;Research;Resistance;resistance mechanism;response;Role;Safety;Sampling;Signal Pathway;Specimen;System;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Time;Tissue Sample;Training;transcriptome sequencing;translational scientist;treatment response;tumor;Tumor stage;Tumor Tissue;tumor-immune system interactions;United States;Universities;whole genome;Woman;Women's mortality

PROJECT_TITLE: Integrative subtyping to improve therapeutic options for metastatic hormone receptor-positive breast cancer

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Genetics;Human Genome;Physical Activity;Physical Rehabilitation;Prevention;Prostate Cancer;Rehabilitation;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project narrative In this grant, we will investigate, for the first time, whether and how exercise alters molecular, clinical, and symptom outcomes in men with localized prostate cancer. As such, if successful, the findings of this study could significantly enhance the management of men initiating active surveillance as well as provide essential formative information to guide larger definitive trials.

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;JONES, LEE W (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: 2 arm randomized control trial;Acute;Architecture;arm;Behavioral;Biopsy;Biopsy Specimen;Cessation of life;Clinic;Clinical;clinical risk;Confidence Intervals;conventional therapy;cost;Data;Diagnosis;Diagnostic;Exercise;exercise capacity;Exercise Therapy;Freezing;Future;genome sequencing;genome-wide;Genomic Instability;Grant;health related quality of life;high risk;Histology;Home;Hypoxia;Image;improved;Incidence;Intervention;Investigation;Local Therapy;Localized Disease;Magnetic Resonance Imaging;Malignant neoplasm of prostate;men;Molecular;Monitor;mouse model;Nature;Neoplasm Metastasis;Noninfiltrating Intraductal Carcinoma;novel;Observational Study;Operative Surgical Procedures;Outcome;overtreatment;Pathologic;Pathologist;Patient Self-Report;Patients;Phase II/III Trial;Physical activity;post intervention;preclinical study;prevent;primary endpoint;programs;progression marker;prospective;prostate biopsy;prostate cancer model;prostate cancer progression;prostate cancer risk;PSA screening;Quality of life;Radiology Specialty;Random Allocation;Randomized;randomized trial;Randomized, Controlled Trials;Research;response;Safety;Sample Size;Sampling;Screening Result;serum PSA;standard of care;Structure;Symptoms;Telemedicine;Testing;Therapeutic Intervention;Time;Toxic effect;transcriptome sequencing;Translating;treadmill;treatment as usual;trial design;tumor progression;Untranslated RNA;Walking;whole genome;Width

PROJECT_TITLE: Randomized Trial of Exercise Therapy on Markers of Progression in Localized Prostate Cancer:

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Helicobacter pylori causes gastric cancer and is the strongest known risk factor for this malignancy. H pylori infects an estimated 28-53% of Veterans. Risk factors for both disease-related complications due to persistent H pylori infection and treatment-related complications are over-represented in the Veteran population compared to the US civilian population. Defining host-level genetic and non-genetic determinants of eradication failure is critical to maximizing initial H pylori eradication success and minimizing the unintended downstream consequences of a failed therapeutic response. The deliverables from this CDA-2 will be: 1) immediately actionable data that will be used to personalize the therapeutic approach for Veterans who are infected with H pylori in order to optimize their individual responses to therapy, and 2) the transformation of a capable and talented early career investigator into a VA Merit-funded physician-scientist dedicated to improving H pylori outcomes among Veterans

PI_NAMEs: SHAH, SHAILJA C (contact)

PROJECT_TERMS: Accounting;Acids;Adherence;adverse outcome;Aftercare;Antibiotic Resistance;Antibiotics;Area;Asian;Big Data;biobank;Biological;Cancer Burden;Cancer Etiology;career;Clinical;clinically relevant;cohort;comorbidity;Data;Data Analyses;data warehouse;Databases;Dedications;design;Diabetes Mellitus;Disease;Disease Outcome;Dose;drug metabolism;Electronic Health Record;Epidemiologic Methods;Epidemiology;ethnic minority;Failure;Frequencies;Funding;Future;gastric cancer prevention;Gastroenterologist;Gastrointestinal Hemorrhage;Genetic;Genetic Determinism;genetic epidemiology;genetic variant;genome wide association study;genomic locus;Genomics;Genotype;geographic difference;Geography;Goals;Health;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;human old age (65+);Immune response;improved;Incidence;Individual;individual response;Inflammatory Response;Institution;Interdisciplinary Study;Knowledge;Lead;Life Style;Link;Logistic Regressions;Malignant Neoplasms;malignant stomach neoplasm;medication nonadherence;Mendelian randomization;Mentors;Metabolism;Methodology;military veteran;Morbidity - disease rate;mortality;non-genetic;Outcome;pathogen;Pathology;Patient Care;Pattern;Peptic Ulcer;personalized approach;personalized therapeutic;Pharmaceutical Preparations;Physicians;Population;predictive modeling;Predisposition;Prevalence;programs;Prospective Studies;racial minority;Randomized, Controlled Trials;Regimen;Regression Analysis;Regulation;Research;Research Design;Research Personnel;Research Priority;Resource Allocation;Resources;Risk;Risk Factors;Science;Scientist;Smoking;success;support tools;System;Talents;Testing;Time trend;Translating;treatment optimization;treatment response;trend;United States;Variant;Veterans;Work;World Health Organization

PROJECT_TITLE: Optimization of Helicobacter pylori-related Disease Outcomes in Veterans


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Pancreatic Ductal Adenocarcinoma (PDAC), a common type of pancreatic cancer, is the fourth leading cause of cancer-related deaths in both men and women in the United States. The goal of the proposed project is to develop an artificial intelligence algorithm based on computed- tomography scans to identify individuals at high risk for PDAC, which may allow early detection and increase survival rate.

PI_NAMEs: LI, DEBIAO  (contact);PANDOL, STEPHEN J.;TIRKES, TEMEL

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: abdominal CT;Abdominal Pain;Accounting;Age;American;Artificial Intelligence;artificial intelligence algorithm;automated segmentation;Biological;Biological Markers;Biopsy;Cancer Etiology;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinically significant;Collection;comorbidity;Data;Data Set;Death Rate;deep learning;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;Early Diagnosis;Early treatment;Emergency department visit;Enrollment;Epidemiology;experience;Eye;follow-up;Future;Gender;Goals;Head;high risk;high risk population;human error;Image;Image Analysis;imaging study;improved;Incidence;Individual;Laboratories;large datasets;Low Prevalence;Machine Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuals;Medical center;men;Modeling;Morphology;Operative Surgical Procedures;Pancreas;pancreas imaging;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;Patients;predictive modeling;premalignant;radiologist;radiomics;Reader;Resectable;Risk;risk prediction;risk stratification;Scanning;Screening procedure;Shapes;Statistical Data Interpretation;Survival Rate;Symptoms;Tail;Techniques;Testing;Texture;Time;Training;Training Technics;tumor;United States;Validation;Visit;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Pancreatic Ductal Adenocarcinoma (PDAC) Through Artificial Intelligence Analysis of Pre-Diagnostic CT Images


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Glioblastomas and malignant astrocytomas are the third leading cause of cancer-related death among middle aged men and the fourth leading cause of death for women between 15-34 years of age. The National Cancer Institute has issued a request for multi-institutional teams to form a national glioblastoma therapeutics network (“GTN”). In response, scientists and clinicians from three institutions in the Dana-Farber/Harvard Cancer Center have joined forces with their counterparts in the Stanford Cancer Center to create a bi-coastal “Harvard/Stanford GTN”.

PI_NAMEs: BATCHELOR, TRACY T (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Adult;Adult Glioblastoma;Agar;Age Years;Agreement;Anabolism;Anaplastic astrocytoma;antagonist;Astrocytoma;Basic Science;Biometry;Brain;Cancer Center;Cancer Etiology;cancer genetics;cancer imaging;Cancer Patient;Cause of Death;cell type;Cells;Cessation of life;Clinical;clinical efficacy;clinical material;Clinical Pharmacology;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Communities;cost effective;Data;Dedications;Doctor of Medicine;Drug Monitoring;early phase clinical trial;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;experience;Failure;feeding;Funding;Funding Opportunities;Generations;Genomics;Glioblastoma;Glioma;Glutamates;Goals;Image;imaging facilities;improved;inhibitor;insight;Institution;lead optimization;Ligands;Magnetic Resonance Spectroscopy;Malignant Neoplasms;mass spectrometric imaging;men;Metabolic;Methodology;middle age;Modeling;mutant;Mutation;National Cancer Institute;neoplastic cell;Nervous System;Neurons;neuropathology;Neurosciences;neurotransmission;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Penetrance;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plasma;Population;Pre-Clinical Model;preclinical development;Principal Investigator;Prodrugs;programs;Protocols documentation;Pyrimidine;Research Personnel;Research Project Grants;Resources;response;Role;Science;Scientist;Services;Signal Transduction;single-cell RNA sequencing;skills;small molecule;small molecule therapeutics;Specific qualifier value;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;structural biology;Sum;Synapses;Testing;Therapeutic;Tissues;Translational Research;translational scientist;tumor;tumor addiction;tumor growth;Visualization;Wit;Women's mortality;Work

PROJECT_TITLE: Harvard/Stanford GTN Program:  Novel targeted therapeutics for glioblastoma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Administrator;Adult Glioblastoma;Cancer Center;career development;Catchment Area;Clinical;Clinical Trials;Collaborations;Communication;Communication Programs;community engagement;Community Outreach;Complex;Dana-Farber Cancer Institute;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;drug development;Electronic Mail;Electronics;experience;Faculty;Fostering;Funding;Funding Opportunities;General Hospitals;Genomics;Glioblastoma;Glioma;Goals;Grant;Hospitals;Human Resources;Image;industry partner;Infrastructure;Institution;inter-institutional;Leadership;Massachusetts;Medical;meetings;Mentored Clinical Scientist Development Program;Mentorship;Monitor;multidisciplinary;new therapeutic target;Parents;Patients;pharmacologic;Pilot Projects;Principal Investigator;programs;recruit;research and development;Research Personnel;Research Project Grants;Resources;response;Scientist;Series;Site;Specialist;Structure;Students;Therapeutic;Training;translational scientist;Universities;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Although pancreatic cancer is a deadly disease with a dismal prognosis, it arises through non-invasive precursor lesions that are curable if detected early enough. The goal of this project is to characterize the role of selective forces in the evolution of precancerous pancreatic neoplasms using genomic and transcriptomic analysis of human tissue samples and three-dimensional cultures, followed by novel computational approaches for data integration. The results will provide critical insights into premalignant pancreatic tumorigenesis, providing a rational foundation for the development of early detection and prevention approaches.

PI_NAMEs: FERTIG, ELANA ;KARCHIN, RACHEL ;WOOD, LAURA DELONG (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: 3-Dimensional;Algorithmic Analysis;Architecture;Automobile Driving;Bayesian Modeling;Biological Assay;Biological Models;Cancer Etiology;cancer invasiveness;cell growth regulation;Cells;Cessation of life;Clonal Evolution;cohort;Complement;computer framework;Computing Methodologies;Data;data integration;deprivation;Development;Disease;DNA;DNA analysis;DNA Integration;DNA Sequence Alteration;DNA sequencing;Early Diagnosis;Event;Evolution;Excision;Experimental Models;Foundations;Gene Expression Profile;Genetic;Genetic Heterogeneity;genetic signature;Genetic Transcription;genome sequencing;Genomic Segment;Genomics;Goals;Growth Factor;High grade dysplasia;Human;human model;human tissue;Hypoxia;in silico;In Vitro;innovation;insight;Investigation;Knowledge;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediation;Methods;Modeling;Molecular;Molecular Analysis;Molecular Computations;molecular dynamics;Mucinous Neoplasm;Multiomic Data;multiple omics;Mutation;novel;Nucleotides;Organoids;Pancreas;pancreatic neoplasm;pancreatic tumorigenesis;Papillary;Pathway interactions;Pattern;Positioning Attribute;premalignant;Premalignant Cell;pressure;prevent;Prevention approach;Process;Prognosis;Research;RNA;Role;Sampling;single cell analysis;single-cell RNA sequencing;Site;Specimen;supervised learning;System;Time;Tissue Sample;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;tumor;tumor heterogeneity;tumor progression;United States;Validation;Variant;whole genome;Wood material

PROJECT_TITLE: Interrogation of the Impact of Selection on the Evolution of Human Pancreatic Cancer Precursor Lesions


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

PHR: Narrative Post-stroke dementia is an important and understudied component of the vascular contributions to cognitive impairment and dementia. Here we will study imaging and blood biomarkers for blood-brain barrier compromise and ask whether they predict cognitive decline in a multicenter study of chronic stroke. If we are successful, we will be able to identify people with chronic stroke who are at risk of future dementia and learn whether blood- brain barrier integrity is important in post-stroke dementia.

PI_NAMEs: BUCKWALTER, MARION S (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Accounting;Age;Aging;angiogenesis;Angiogenic Factor;Angiogenic Proteins;aptamer;Autopsy;Biological Markers;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain region;Bypass;Cardiac;Cardiovascular system;Cells;cerebral atrophy;Characteristics;Chronic;chronic stroke;Cicatrix;Clinical;Clinical Trials;Cognition;Cognitive;cognitive testing;comparison control;contrast enhanced;Data;Data Element;Data Set;Dementia;dementia risk;Development;Enzyme-Linked Immunosorbent Assay;experimental study;Extravasation;follow-up;Functional disorder;Future;high risk;Human;Image;imaging biomarker;Impaired cognition;improved;Individual;Inflammation;Ipsilateral;Learning;Lesion;Link;Location;Longitudinal cohort study;machine learning model;Magnetic Resonance Imaging;Measures;medical schools;Modeling;MRI Scans;Multicenter Studies;Mus;neuroinflammation;novel therapeutics;Operative Surgical Procedures;Participant;Pathway interactions;Patient Selection;Pericytes;Persons;Phase;Plasma;Plasma Proteins;Platelet-Derived Growth Factor B;post stroke;post stroke cognitive impairment;post stroke dementia;predictive modeling;primary outcome;prospective;Proteins;Proteomics;Radiology Specialty;recruit;Risk;Risk Factors;risk prediction;secondary outcome;sex;Site;Stroke;stroke survivor;Testing;therapy development;Universities;vascular cognitive impairment and dementia;Vascular Dementia;vascular factor;vascular risk factor;Wild Type Mouse

PROJECT_TITLE: BBB dysfunction in post-stroke dementia

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: SUVA, MARIO LUCA (contact)

PROJECT_TERMS: Adult Glioblastoma;Agar;Animal Model;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;Brain Neoplasms;brain tissue;cancer cell;cancer heterogeneity;Cells;Clinic;Clinical;Clinical Research;Clinical Trials;Complex;Consent;Cryoultramicrotomy;Dana-Farber Cancer Institute;Data;data sharing;Dedications;design;Development;digital imaging;Disease;drug candidate;drug distribution;Drug or chemical Tissue Distribution;Drug Targeting;effective therapy;Ensure;Epigenetic Process;Equipment;Experimental Models;fluorescence imaging;Freezing;Gene Expression;Genetic;genome-wide;Genomics;Glioblastoma;Glioma;Goals;Heterogeneity;Histopathology;Hospitals;Human Resources;Image;imaging capabilities;imaging system;Immune;improved;in vivo imaging;Infrastructure;innovation;Knowledge;liquid crystal polymer;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Metabolic Pathway;metabolomics;Methods;Modeling;mouse model;Multi-Institutional Clinical Trial;Multiplexed Ion Beam Imaging;Mus;neoplastic cell;Neuroglia;Neurons;neuropathology;new therapeutic target;novel;Organ;Pathway interactions;patient derived xenograft model;patient oriented;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;Pharmacotherapy;Pre-Clinical Model;Procedures;programs;Proteins;Quality Control;Reagent;Reproducibility;Resistance;Resolution;Resources;response;Sampling;Services;Signal Transduction;single cell genomics;single cell technology;single nucleus RNA-sequencing;Site;Slide;Specimen;Standardization;success;targeted therapy trials;Technical Expertise;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Tissues;transcriptomics;treatment response;tumor;tumor heterogeneity;tumor microenvironment

PROJECT_TITLE: Pharmacologic and Genomic Imaging Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Hypertension;Infectious Diseases;Prevention;Primary Health Care

ORG_CITY: ABUJA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: UNIVERSITY OF ABUJA

PHR: Project Narrative People Living With HIV (PLWH) are at increased risk for Non-Communicable Diseases (NCDs) including, cardiovascular diseases (CVD) with hypertension (HTN) as the most common. Integration of NCD management into HIV chronic care platforms may be a cost-effective strategy to mitigate the rising burden of NCDs in PLWH. The goal of the study is to evaluate the effectiveness of practice facilitation in the integration of a task-shifting strategy for hypertension control into Strengthening Integrated Delivery of HIV/AIDS Services (SIDHAS) HIV care platform for 960 PLWH across 30 PHCs in Akwa Ibom State. This Proposed study will occur in two phases: 1) UG3 Planning Phase using the PARiHS framework to explore factors and support systems required for successful implementation and integration of TASSH into existing HIV chronic care platform and development of a context-specific practice facilitation strategy. 2) UH3 Implementation Phase will use RE-AIM framework to evaluate in a stepped-wedge cluster RCT the effect of the practice facilitation strategy on the level of adoption of TASSH, BP control and level of sustainment of TASSH in management of HTN among 960 HIV+ patients across 30 PHCs. Findings will have public health impact and will contribute to improved efforts for management of HTN in PLWH in low- and middle-income countries.

PI_NAMEs: ATTAH, ANGELA ;IWELUNMOR, JULIET ;OGEDEGBE, OLUGBENGA G.;OJJI, DIKE BEVIS (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;Advocate;Africa;Anti-Retroviral Agents;blood pressure control;blood pressure reduction;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Chronic;Chronic Care;Collaborations;Communication;comorbidity;cost effective;Counseling;Country;Data;Data Analyses;Data Collection;Decision Making;design;Development;Diabetes Mellitus;Disease;Disease Management;effectiveness evaluation;evidence base;Evidence based intervention;experience;Faculty;Family health status;feasibility testing;Feedback;Funding;General Population;Ghana;Goals;Grant;Health;Health Insurance;Health Services;Health Services Accessibility;Healthcare Systems;HIV;HIV/AIDS;Hypertension;hypertension control;implementation fidelity;implementation framework;implementation protocol;implementation science;implementation strategy;improved;Income;Infrastructure;Insurance Coverage;International;Intervention;Knowledge;knowledge base;Leadership;Life Style;low and middle-income countries;Managed Care;Manuals;Methods;Modeling;Monitor;mortality;Needs Assessment;New York;Nigeria;Nurses;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Physicians;pilot test;Prevalence;Primary Care;primary health center;primary outcome;Procedures;Process;programs;Protocols documentation;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;research to practice;Risk;Risk Assessment;Role;routine practice;secondary outcome;service programs;Services;Site;Support System;System;Testing;Titrations;Training;Training Support;Translating;United States National Institutes of Health;Universities;USAID

PROJECT_TITLE: Managing Hypertension Among People Living with HIV: an Integrated Model (MAP-IT)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We aim to identify the molecular mechanisms underlying inflammation in human age-related macular degeneration (AMD), and define how they contribute to new blood vessel formation and vision loss. Our research may give insight into the development of novel therapies for patients with wet AMD by targeting immune pathways to prevent the inflammation in disease.

PI_NAMEs: HAFLER, BRIAN P (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: age related;Age related macular degeneration;angiogenesis;Atlases;Autopsy;Blindness;blood vessel development;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Choroidal Neovascularization;Chronic;cytokine;Data;Deposition;Development;Disease;Disease Progression;drug discovery;Drusen;Elderly;Excision;extracellular;Exudative age-related macular degeneration;Eye;Fluorescence-Activated Cell Sorting;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;genetic signature;Goals;Human;human tissue;IL17 gene;Immune;immune checkpoint;Immune Targeting;Immunohistochemistry;improved;In Situ Hybridization;Individual;Inflammation;Inflammatory;Inflammatory Response;Injections;insight;Interleukin Activation;Interleukin-1 beta;Interleukin-10;Interleukins;Investigation;Knowledge;Lead;Lesion;Lipids;Macrophage;matrigel;Mediating;Microglia;Modeling;Molecular;Molecular Profiling;monocyte;Muller's cell;Mus;neovascularization;Nerve Degeneration;Neuroglia;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Phenotype;Photoreceptors;Play;prevent;Production;Proteins;Quality of life;Research;Retina;Retinal Degeneration;Risk;Role;Services;Signal Pathway;Signal Transduction;Signaling Molecule;single cell analysis;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;System;Techniques;therapeutic target;therapeutically effective;Transcription Alteration;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;Up-Regulation;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Targeting the inflammatory response in age-related macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]