NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: JAN, MAX  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affinity;age group;Antigen Targeting;Antigens;Antineoplastic Agents;Architecture;aspirate;Binding;Boston;Brain;CAR T cell therapy;CD276 gene;Cell Physiology;Cells;Cellular immunotherapy;Chemicals;Chemistry;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;clinical implementation;clinical translation;Clinical Trials;clinically relevant;Combination immunotherapy;Complex;CRISPR/Cas technology;Cytostatics;Data;Dependence;design;Development;Diagnosis;Disease;Down-Regulation;Drug Controls;drug development;Drug Targeting;drug testing;early phase clinical trial;engineered T cells;Engineering;Ependymoma;Equilibrium;Evaluation;Ewings sarcoma;exhaustion;FOXO1A gene;Functional disorder;Funding;Gene Expression;Genes;Glioma;Glues;Heterodimerization;Heterogeneity;high risk;Immune;immune modulating agents;Immunology;immunoregulation;improved;in vivo;in vivo Model;Individual;inhibitor;innovation;insight;Interphase Cell;Intervention;Investigation;Kinetics;Legal patent;lenalidomide;Link;Logic;Malignant Childhood Neoplasm;Malignant Neoplasms;Massachusetts;Mediating;Memory;Methods;Modeling;Molecular;mortality;Mutation;neoplastic cell;Neural Cell Adhesion Molecule L1;Neuroblastoma;novel;Oncogenic;Oncoproteins;operation;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Physiologic pulse;pre-clinical;prevent;Printing;progenitor;programs;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;Publishing;receptor expression;receptor function;Receptor Signaling;Recovery;recruit;Regulation;Research Personnel;Resistance;resistance mechanism;Rest;Risk;screening;Signal Transduction;small molecule;Solid;Solid Neoplasm;Specificity;structural biology;success;Survival Rate;synovial sarcoma;synthetic biology;System;T memory cell;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Tertiary Protein Structure;Testing;Thalidomide;Therapeutic;tool;tool development;Toxic effect;transcription factor;Transgenes;translational potential;tumor;Tumor Antigens;Tumor Biology;tumor growth;ubiquitin-protein ligase;Zinc Fingers

PROJECT_TITLE: PROTECT - Harnessing Protein Degradation for Advancing Childhood Tumors


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: FRESNO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

ORG_STATE: CA

PHR: Project relevance: This project will contribute to the characterization of novel chalcone nematicidal agents needed to control parasitic nematodes in animals (including humans) and plants. Therefore, developing new nematicidal agents and understanding their mechanism of action is of paramount importance for human health.

PI_NAMEs: CALDERON-URREA, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TITLE: Nematicidal Chalcones: A Genetic Approach to Uncovering the Action Mechanism


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: NEUROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative  Retinal prostheses restore limited visual perception to the blind by stimulating still viable cells in the eye with an implanted device, particularly for patients with Retinitis Pigmentosa (RP) and potentially Age-Related Macular Degeneration (AMD). We will investigate whether the sensory reorganization that occurs during blindness limits the restoration of vision with intraocular retinal prostheses, which may have implications for emerging alternative approaches such as stem cells and gene therapy as well. This study will advance the understanding of how the brain adapts to vision loss and subsequent vision restoration, which are key to improving patient selection, therapeutic choice, and visual rehabilitation outcomes.

PI_NAMEs: STILES, NOELLE  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Advisory Committees;Age related macular degeneration;Artificial Implants;Auditory;Auditory Perception;Basic Science;behavior test;Biomedical Engineering;blind;Blindness;Brain;Brain region;career;Case Study;Cell Survival;Cochlear Implants;Control Groups;Data;Data Collection;deprivation;design;Deterioration;Devices;Diffusion Magnetic Resonance Imaging;Electric Stimulation;Engineering;Evaluation;Exhibits;Eye;Faculty;faculty research;feeding;flexibility;Foundations;Functional Magnetic Resonance Imaging;functional outcomes;gene therapy;Glass;Head;Imagination;Implant;implantable device;implantation;improved;Individual;Investigation;Location;Magnetic Resonance Imaging;Mentors;Methods;Michigan;Microelectrodes;Modality;Motion Perception;multimodality;neural;neuroimaging;Neurosciences;Ocular Prosthesis;Operative Surgical Procedures;Optic Chiasm;Outcome;Participant;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Perception;Phase;Population;Positioning Attribute;Postdoctoral Fellow;preimplantation;Process;programs;Property;Prosthesis;Prosthesis Implantation;Psychophysics;Recovery;Rehabilitation Outcome;Research;restoration;Retina;retinal imaging;retinal prosthesis;Retinitis Pigmentosa;Scanning;Selection Criteria;Sensory;Sensory Deprivation;sensory integration;Shapes;sight for the blind;sight restoration;skills;Sound Localization;stem cell therapy;Stimulus;Structure;Tactile;tenure track;Testing;Therapeutic;Thick;Training;Translational Research;Universities;Vision;Visual;Visual Cortex;Visual impairment;visual information;Visual Pathways;Visual Perception;visual processing;visual stimulus;Visualization;Visually Impaired Persons;Work

PROJECT_TITLE: Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Understanding the process of normal head and facial development is essential for developing new strategies to prevent and treat birth defects, which significantly affect the national health care budget. This project will generate new models to study developmental disorders including Treacher Collins syndrome and will examine new molecular mechanisms governing the development of neural crest cells, which are critical for head development.

PI_NAMEs: WATT, KRISTIN EMILY NOACK (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;Award;Biochemical;Biogenesis;bone;Budgets;Cartilage;Cell Culture Techniques;Cell Death;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;Communities;Congenital Abnormality;Connective Tissue;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;craniofacial disorder;Data;Dental;Development;developmental disease;differential expression;Disease;disease-causing mutation;DNA Polymerase I;DNA Polymerase III;DNA-Directed RNA Polymerase;Embryo;Embryonic Development;Etiology;Face;Fibroblasts;Foundations;Future;Genes;Genetic Transcription;Genomics;Goals;Head;Healthcare;Human;human induced pluripotent stem cells;Hypodontia;improved;in vivo;Individual;Infant Mortality;Knowledge;Mandibulofacial Dysostosis;Mediating;Mentors;migration;Modeling;Molecular;mutant;Mutation;Neural Crest Cell;neurodevelopment;novel;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Phase;Phenotype;Population;Prevalence;prevent;Prevention;Process;programs;Proliferating;Protein Biosynthesis;Regulation;Research;Resources;Ribosomal RNA;ribosome profiling;Ribosomes;ribosomopathy;RNA analysis;RNA chemical synthesis;RNA Polymerase III;RNA, Ribosomal, 5S;Role;Small RNA;spatiotemporal;Specificity;stem cells;Syndrome;System;Testing;Therapeutic Intervention;Tissues;Tooth structure;Training;Transcript;transcriptome sequencing;Transfer RNA;Translations;United States;Untranslated RNA;Variant;Work;Zebrafish

PROJECT_TITLE: Understanding RNA Polymerase III transcription in neural crest cell and craniofacial development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PROVO

ORG_DEPT: CHEMISTRY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE  The cytosolic chaperonin CCT is an essential molecular chaperone that assists in the folding and assembly of protein complexes vital to cellular function. We have evidence that the SARS-CoV-2 virus co-opts CCT to assemble its RNA polymerase complex and replicate the viral RNA. We propose to investigate this process using biochemical and high-resolution cryo-electron microscopy structural techniques to provide a scaffold for structure-based design of anti-viral drugs to treat COVID-19 and other viral diseases.

PI_NAMEs: WILLARDSON, BARRY M (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 2019-nCoV;Anti-viral Agents;ATP Hydrolysis;Binding;Biochemical;Catalytic Domain;Cell Communication;Cell Physiology;Cells;chaperonin;chaperonin CCT;combat;Communities;Complex;Coronavirus;COVID-19 pandemic;COVID-19 treatment;Cryoelectron Microscopy;cytosolic chaperonin;design;Diagnostic;DNA-Directed RNA Polymerase;experience;experimental study;Feasibility Studies;FRAP1 gene;Future;Genetic Transcription;global health;GTP-Binding Proteins;Hepatitis C;HIV;Influenza A virus;inhibitor;Investigation;Knowledge;Mediating;Molecular;Molecular Chaperones;Molecular Conformation;Nonstructural Protein;novel therapeutics;Nucleotides;Play;Polymerase;Positioning Attribute;Process;Process Measure;protein complex;protein folding;Proteins;Proteome;Rabies;Reovirus;Resolution;RNA;Role;scaffold;small molecule;small molecule inhibitor;Structure;System;Techniques;Testing;Therapeutic;Variant;Viral;Viral Proteins;viral RNA;Virus;Virus Assembly;Virus Diseases;Virus Replication;Work;ZIKA

PROJECT_TITLE: Molecular Mechanism of Folding of Nsp12 and Assembly of the SARS-CoV-2 RNA Polymerase Complex by the Cytosolic Chaperonin CCT

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE  1) This application is crucial for deciphering human diseases tied to ribosome biology and  protein synthesis, potentially leading to novel treatments for conditions like Diamond-  Blackfan Anemia. 2) It will strengthen the research environment at Wake Forest University, ranked #47 in the  nation by U.S. News (https://www.usnews.com/best-colleges/rankings/national- universities). 3) It will contribute to the research training of highly intelligent, highly motivated BA, MA,  and PhD students destined for Molecular Biology and Biochemistry research careers.

PI_NAMEs: REID, KE ZHANG (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Affinity Chromatography;Amino Acid Sequence;Amino Acids;Area;Automobile Driving;Biochemical;Biochemistry;Biological;Biological Models;Biology;Bone Marrow;career;cell growth;cell type;Cells;Cellular biology;Child Care;Code;college;Complex;Data;design;Development;Diamond-Blackfan anemia;differential expression;Disease;doctoral student;Environment;environmental stressor;Erythrocytes;Exhibits;experimental study;Fission Yeast;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;GRASP gene;Growth;Heat Stress;Hemorrhage;Heterogeneity;human disease;improved;Individual;insight;Investigation;Lead;Life;link protein;Messenger RNA;Methods;Molecular;Molecular Biology;mRNA Translation;mutant;Mutation;news;novel;Open Reading Frames;Organism;Outcome;paralogous gene;Patients;Pattern;Phenotype;Polyribosomes;polysome profiling;Population;Prevalence;Protein Biosynthesis;Protein Subunits;Proteins;Regulatory Element;Research;Research Training;response;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Sequences;Role;Scientist;Specificity;stem;Stress;Structure;Testing;Textbooks;Tissue-Specific Gene Expression;transcriptome sequencing;Translating;Translations;translatome;Universities;Untranslated Regions;Variant;Virus Diseases;Work

PROJECT_TITLE: Functional diversity of large ribosomal protein 27 and small ribosomal protein 19 paralogs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (81)]


ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative While it is clear that the microbiota play a key role in human health, we lack an understanding of the physiological processes that determine microbiota composition across the body. To address this gap, the the goals of this proposal are to i) identify relationships between host genes and mucosal bacteria and archaea, ii) identify non-prokaryotic elements of the human microbiome associated with human gene expression and ii) demonstrate causal relationships between the microbiome and host gene expression. Ultimately, the results of this project will inform our understanding of the relationship between the microbiota and host in health and disease and highlight areas of interest for novel, microbiome-based therapeutics.

PI_NAMEs: DAVENPORT, EMILY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Archaea;Area;Bacteria;Body System;cell type;Complex;Data;Disease;Ecosystem;Elements;Epidemiologic Methods;Equipment;Etiology;Eukaryotic Cell;fecal microbiome;functional genomics;fungus;Gene Expression;Genes;Genetic;genetic approach;genetic epidemiology;Genomic approach;Goals;Gut Mucosa;Health;Heritability;host microbiota;Human;Human body;Human Genetics;Human Microbiome;improved;In Vitro;Individual;insight;interest;Lead;Lung;lung microbiota;microbial;microbiome;microbiome composition;microbiome therapeutics;microbiota;microbiota composition;Molecular;Mucous Membrane;novel;Organism;Pathway interactions;Physiological;Physiological Processes;Play;programs;Research;Research Methodology;Sampling;single-cell RNA sequencing;Site;Surface;targeted treatment;Tissues;trait;Virus;Work

PROJECT_TITLE: Characterizing human-microbiome interactions via molecular and functional genomic approaches - Equipment Supplement


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Understanding how cellular behaviors add up to organ-scale phenotypes requires the ability to observe organs in their native contexts, with subcellular resolution, over sufficiently long periods to capture long-timescale processes. My lab has pioneered live imaging techniques that enable us to make long-term and longitudinal observations in the Drosophila midgut, a superb model for stem cell and epithelial organ biology. Here, we propose how stem cells array themselves to respond to and replace cells that are being eliminated from the tissue as well as how new, differentiating cells integrate into existing cellular networks. Project Narrative Page 7

PI_NAMEs: O'BRIEN, LUCY ERIN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;adult stem cell;Biological Models;Biology;cell behavior;Cell Death;Cell Differentiation process;cell motility;Cells;Complex;Drosophila genus;EGF gene;Epithelium;Equilibrium;Feedback;flexibility;Funding;Goals;grasp;Health;Homeostasis;Human;imaging capabilities;Imaging Techniques;in vivo;Individual;Kinetics;Life Cycle Stages;Maintenance;Midgut;Organ;Organ Model;Organ Size;Output;Phenotype;Population;precision genetics;Process;programs;Property;Regulation;repaired;Resolution;seal;self-renewal;Signal Transduction;Small Intestines;Source;Spatial Distribution;stem cell division;stem cell model;stem cells;stemness;Stomach;Thinking;Tight Junctions;Time;Tissues;tool;Tubular formation;Work

PROJECT_TITLE: Organ-scale regulation of stem cell dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Regenerative Medicine

ORG_CITY: BETHLEHEM

ORG_NAME: LEHIGH UNIVERSITY

PHR: RELEVANCE (See instructions): Biological tissues are highly organized structures with heterogeneous collagen matrix arrangements. However, fundamental challenges present in understanding how such heterogeneity affects the growth and remodeling of various collagenous bio-tissues, due to limited knowledge on holistic understandings of the multi-scale interactions between cell signaling and heterogeneous matrix remodeling. To address this critical need, the data-dri ven multi-scale approaches proposed herein will provide new insights into the underlying biological and mechanical implications of matrix heterogeneity.

PI_NAMEs: YU, YUE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Affect;Aging;Aneurysm;Behavior;Biological;biomathematics;Biomechanics;bone reconstruction;Cartilage;Cells;Collagen;Data;data integration;data-driven model;digital twin;Experimental Designs;experimental study;Extracellular Matrix;Failure;Fibroblasts;Goals;Growth;Heterogeneity;human tissue;improved;In Vitro;in vivo;in vivo Model;Information Theory;insight;Instruction;Knowledge;Learning;Machine Learning;Measurement;Measures;mechanical behavior;mechanical properties;Mechanics;Mediating;Modeling;multi-scale modeling;multimodality;multiscale data;multitask;network models;novel;organizational structure;Performance;Physics;Play;Population;predictive tools;Role;Signal Transduction;Structure;System;Techniques;Therapeutic Intervention;Time;tissue degeneration;Tissue Model;tissue reconstruction;Tissues;Traumatic Brain Injury;virtual screening

PROJECT_TITLE: Integrate Data-Driven Modeling and Multi-scale Measures Towards Tissue Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-X (BM)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: ORONO

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: Customizable 3D Matrix to Investigate Glycan Function Pi: Matthew Brichacek; Co-I: William Gramlich, University of Maine Project Narrative The proposed research will create a diagnostic material system to identify and quantify interactions between glycans and protein. New synthetic techniques will be developed to create thiol-functionalized glycans that probe fundamental biomacromolecule interactions with precise spatiotemporal control of glycan type and activity. Incorporation of these probes into novel biomaterials will benefit human health by enabling a diverse set of scientists to identify glycans relevant to human health and explore their effects in a controlled and customizable extracellular environment.

PI_NAMEs: BRICHACEK, MATTHEW PAUL (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (82)]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Wound Healing and Care

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: RELEVANCE (See instructions): Abnormal development and cancer growth involve both solid and fluid properties in living tissues, but understanding their precise impact on pathological processes requires further investigation. This project aims to develop mathematical theories, numerical methods, and experiments to study how fluidity is patterned at both tissue and cellular levels during in vitro tissue wound closure.

PI_NAMEs: WU, MIN  (contact)

PROJECT_TERMS: Actins;Cell Aggregation;Cell Line;Cells;Coupled;Development;Epithelium;Equation;Evolution;experimental study;fluidity;Goals;Growth;Hybrids;In Vitro;Intercalated Cell;Intercellular Junctions;Investigation;kinematics;Liquid substance;Malignant Neoplasms;Massachusetts;mathematical theory;Mechanics;Mesenchymal;Methods;migration;monolayer;Morphogenesis;multi-scale modeling;novel;Pathologic Processes;Pattern;Phenotype;Property;Protocols documentation;Qi;Regulation;Solid;Spatial Distribution;spatiotemporal;System;theories;Time;tissue regeneration;Tissues;Universities;wound;wound closure

PROJECT_TITLE: Multiscale modeling of fluidity in partial EMT (pEMT) planar tissues


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The ability to target challenging intracellular proteins and protein-protein interactions – "drugging the undruggable" – is a primary challenge in medicinal chemistry today. Membrane permeable macrocyclic peptides (MCPs) inspired by natural products offer a new paradigm for tackling these difficult targets. The proposed program will continue nearly two decades of basic science pioneered in my lab toward understanding and predicting the drug-like properties of MCPs, with the ultimate goal of developing a general platform for lead discovery against undruggable intracellular targets.

PI_NAMEs: LOKEY, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: absorption;Address;analytical tool;Antibodies;Basic Science;Behavior;Cell Membrane Permeability;Cells;Chemicals;Chromatography;Development;DNA;Drug Kinetics;Geometry;Goals;High Pressure Liquid Chromatography;inhibitor;Lead;Libraries;lipophilicity;liver metabolism;Medicine;member;Membrane;Metabolism;Natural Products;Nature;next generation sequencing;novel;Oral;Peptides;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Positioning Attribute;programs;Property;protein protein interaction;Proteins;Research;scaffold;Side;Specificity;System;Technology;Vertebral column

PROJECT_TITLE: Mass-directed preparative HPLC purification system


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: STATE UNIVERSITY

ORG_NAME: ARKANSAS STATE UNIVERSITY

ORG_STATE: AR

PHR: Project Narrative Tooth decay is very prevalent in the United States and a leading cause of the disease is the oral bacterium Streptococcus mutans. In this project we will construct a powerful new genetic tool, a sequence-defined transposon mutant library, that can be applied to identify genetic determinants of S. mutans pathogenicity. The results of this project could lead to the discovery of important genetic factors required for S. mutans to cause tooth decay, and lead to new approaches to control S. mutans infections.

PI_NAMEs: ALAM, MOHAMMAD ABRAR (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acceleration;Adult;Area;Arkansas;Bacteria;Bacterial Model;Biochemical;Biomedical Research;burden of illness;Centers for Disease Control and Prevention (U.S.);Child;Communities;comparative;Complex;Data;demineralization;dental agent;Dental caries;Dental Enamel;Development;Disease;Etiology;Extracellular Matrix;functional genomics;Genes;Genetic;Genetic Determinism;genetic element;genetic manipulation;Genetic Screening;Genetic study;Goals;graduate student;Grant;Growth;Human;improved;in vivo;infancy;Infection;Intention;Knowledge;Laboratories;Libraries;Mediating;Medical;member;Microbial Biofilms;Microscopy;Modeling;Molecular;mutant;novel;novel strategies;oral bacteria;Oral cavity;Oral health;oral pathogen;pathogen;Pathogenesis;Pathogenicity;Quality of life;Research;Resources;Streptococcus;Streptococcus mutans;Sucrose;Testing;Therapeutic;tool;Tooth Loss;training opportunity;trait;Translating;transposon sequencing;undergraduate student;United States;Virulence

PROJECT_TITLE: Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-Q (80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Muscle stem cell exhaustion is one of the hallmarks of aging and leads to gradual impairment of tissue structure and function. Aged stem cells exhibit a decline in resilience, manifested as a reduced resistance to extrinsic and intrinsic stresses, rendering them more susceptible than young stem cells to processes leading to cell death. The main focus of the studies of this proposal is to explore the mechanisms that promote stem cell resilience, how those mechanisms decline with age, and interventions that may promote stem cell resilience in older individuals.

PI_NAMEs: RANDO, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acetylation;Address;Adult;Age;age related;age related changes;age related decline;aged;Aging;aging process;Attention;beta-Hydroxybutyrate;biological adaptation to stress;Blood;Caloric Restriction;Cell Aging;Cell Cycle;Cell Death;Cell Survival;Cells;cellular resilience;Cytoprotection;Data;decrease resilience;Diet;Dietary Intervention;Exhibits;Fasting;functional decline;Functional disorder;Genetic Models;Goals;hallmarks of aging;Heterogeneity;Histone Deacetylase;Histone Deacetylase Inhibitor;Homeostasis;Impairment;In Vitro;in vivo;Injury;Intermittent fasting;Intervention;ketogenic diet;Ketone Bodies;Ketosis;Knock-out;Laboratories;life span;Mediating;Mediator;Mitotic;Molecular;Molecular Profiling;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;Muscle satellite cell;muscular structure;new therapeutic target;notch protein;novel;Older Population;Outcome;Pathway interactions;Phenotype;phosphoproteomics;Population;Predisposition;preservation;prevent;Process;promote resilience;Publishing;regeneration potential;regenerative;Regenerative capacity;Rejuvenation;repaired;replication stress;resilience;resilience biomarker;Resistance;response;response to injury;Role;screening;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell exhaustion;stem cell population;stem cells;Stress;Structure;Testing;Time;Tissues;TP53 gene;Transgenic Organisms;Work

PROJECT_TITLE: Aging and Stem Cell Resilience

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Skin Cancer

ORG_CITY: Houston

ORG_NAME: TRANQUILITY BIODESIGN LLC

ORG_STATE: TX

PI_NAMEs: HAN, SONGLEE  (contact)

PROJECT_TERMS: anti-cancer;anti-cancer therapeutic;Attenuated;Award;Bacteria;Biological Assay;Brucella melitensis;cancer immunotherapy;CD4 Positive T Lymphocytes;Cells;cytotoxic CD8 T cells;Data;Development;DNA cassette;Engineering;Enzymes;Generations;Genetic Engineering;Genome;Genomics;Goat;humanized mouse;hydroxyindole;Immune;Immunocompetent;Immunodeficient Mouse;immunoregulation;improved;Inflammatory;innovation;Macrophage;Merkel cell carcinoma;Mixed Function Oxygenases;mouse model;neoplastic cell;NOD/SCID mouse;nonhuman primate;novel;Phase;pregnant;response;Safety;safety testing;Sheep;Skin Cancer;System;T cell differentiation;T cell therapy;Testing;Therapeutic;therapeutic development;Toluene;Tryptophan;tumor;tumor growth;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: Phase I Therapeutic Award: A Novel Engineered Bacterial Anticancer Immunotherapy for Merkel Cell Carcinoma


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PI_NAMEs: GARCIA, KENAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;Alanine;algorithm development;algorithm training;Algorithms;Antigen Presentation;Antigen Targeting;Antigens;Biochemical;cancer therapy;cancer type;combinatorial;Complex;Computer Models;Computing Methodologies;cross reactivity;cytotoxicity;Data;Data Set;design;Development;Engineering;Event;extend lifespan;Face;Feedback;Generations;Goals;Grant;high throughput screening;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;insight;Institution;large scale data;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;Methods;model development;Modeling;Molecular;mouse model;Mutation;next generation;novel drug class;Peptide/MHC Complex;personalized medicine;Pharmaceutical Preparations;Proxy;quantum;Research Personnel;Resolution;response;Scanning;single cell sequencing;Source;Specificity;structural biology;Structure;Structure-Activity Relationship;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy design;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Vision;Work

PROJECT_TITLE: MATCHMAKERS: SOLVING TCR RECOGNITION AND DESIGN VIA INTEGRATED HIGH-THROUGHPUT SCREENING, STRUCTURAL, FUNCTIONAL, AND COMPUTATIONAL APPROACHES


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Seizures in early life occur in the setting of epilepsy, autism and other neurodevelopmental disorders and emerging evidence suggests that they play a role in later impairments in learning and behavior. This proposal will use a new mouse model to “track” brain cells affected by seizures in early life over time in order to learn how they are altered, with the goal of identifying new therapeutic targets to prevent these negative consequences of early life seizures.

PI_NAMEs: JENSEN, FRANCES E (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;Address;Adult;Affect;antagonist;Attenuated;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Brain;brain cell;Cells;Characteristics;Clinical;Cognitive;Cognitive deficits;comorbidity;comparison control;Complement;critical period;Dendrites;Detection;Development;Electrophysiology (science);Epilepsy;Event;Evolution;Exhibits;FOS gene;Gene Expression;Gene Expression Alteration;Genes;Glutamate Receptor;Goals;Hippocampus;Immediate-Early Genes;Impaired cognition;Impairment;improved;in vivo;inducible Cre;Intellectual functioning disability;Label;late life;Learning;Life;life span;Measurement;Measures;Methods;Modeling;mouse model;Mus;Neurodevelopmental Disorder;Neurons;neurotransmission;new therapeutic target;novel;novel therapeutic intervention;Nuclear RNA;Population;postnatal;Prevalence;prevent;Prevention;protein expression;Proteins;receptor function;recruit;response;RNA;RNA analysis;Rodent Model;Sampling;Seizures;Signal Pathway;Signal Transduction;Slice;social;social deficits;Synapses;Synaptic plasticity;synaptogenesis;Time;Tissue Harvesting;tool;transcriptome sequencing;Work

PROJECT_TITLE: Tracking the evolution of synaptic dysplasticity after early life seizures


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Obesity;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Narrative Statement. Opioid overdose continues to take the lives of tens of thousands of Americans annually. Here, we will test whether treatment with a promising glucagon-like peptide-1R (GLP-1R) agonist, already approved for the treatment of obesity and type 2 diabetes mellitus in humans, can safely and effectively reduce cue/drug/stress-induced reinstatement of heroin seeking behavior in an animal model and, importantly, craving, risk of relapse, and relapse in humans undergoing treatment for an opioid use disorder. If milestones are met, the data will provide a second indication for further multisite clinical trials.

PI_NAMEs: BRICK, TIMOTHY R.;BUNCE, SCOTT C;GRIGSON, PATRICIA SUE (contact);NYLAND, JENNIFER E.

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: addiction;Agonist;Alcohols;American;American soldier;Animal Model;Animals;arm;Behavior;Brain;Buprenorphine;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Clinical Trials;Cocaine;Counseling;craving;Cues;Data;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;Effectiveness;efficacy testing;Epidemic;Female;Fire - disasters;Formulation;GLP-I receptor;glucagon-like peptide;glucagon-like peptide 1;Height;Heroin;Homicide;Human;Ingestion;Letters;liraglutide;male;man;Measures;men;Methadone;Multi-Institutional Clinical Trial;Mus;Naltrexone;Nicotine;Non-Insulin-Dependent Diabetes Mellitus;non-opioid analgesic;novel strategies;obese patients;obesity treatment;Opioid;opioid overdose;opioid use disorder;Outpatients;overdose death;Pathway interactions;Patients;Pennsylvania;Peripheral;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Pilot Projects;Placebo Control;Placebos;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;preference;prevent;pup;Randomized;Rattus;Recording of previous events;Relapse;relapse risk;Reporting;Residential Treatment;response;Rewards;Safety;safety testing;Satiation;Self Administration;Services;Site;Sodium;Sodium Chloride;Stress;Suboxone;Suicide;Testing;Time;treatment center;United States;Vehicle crash;Vietnam;War;Water;Woman

PROJECT_TITLE: Use of a GLP-1 Agonist to Treat Opioid Use Disorder in Rats and Man


NIH_SPENDING_CATS: Genetics

ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project narrative: mRNA 3’ processing is an essential step in eukaryotic gene expression and alternative polyadenylation is an important mechanism for gene regulation. In this proposal, we will characterize the structure-function relationship of the mRNA 3’ processing complex and the mechanisms by which RNA-binding proteins and post-translational modifications of the core mRNA 3’ processing factors regulate alternative polyadenylation.

PI_NAMEs: SHI, YONGSHENG  (contact)

PROJECT_TERMS: Alternative Splicing;Biochemical;Cells;Complex;Development;Disease;Gene Expression;Gene Expression Regulation;Genes;Genomics;Goals;insight;Malignant Neoplasms;Messenger RNA;mRNA Stability;Nervous System Disorder;novel;novel therapeutics;Pattern;Play;Polyadenylation;Post-Transcriptional Regulation;Post-Translational Protein Processing;programs;Protein Isoforms;Regulation;Research;RNA metabolism;RNA-Binding Proteins;Role;Signal Transduction;Structure-Activity Relationship;Translations

PROJECT_TITLE: Mechanisms and regulation of mRNA 3' processing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Myasthenia Gravis;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: COLUMBIA

ORG_NAME: A AND G PHARMACEUTICAL, INC.

ORG_STATE: MD

PI_NAMEs: KOSOWSKY, AKIVA  (contact)

PROJECT_TERMS: Affinity;Antibodies;Biological Assay;Cell Line;Clinical;Congenital Myasthenic Syndromes;Documentation;drug candidate;Drug Kinetics;Epitopes;gene therapy;Human;immunogenicity;Label;method development;Monoclonal Antibodies;Mus;National Center for Advancing Translational Sciences;pre-clinical;Preparation;Toxicokinetics

PROJECT_TITLE: TO6 - GENERATING MONOCLONAL CELL LINES, MONOCLONAL ANTIBODIES, AND LABELED MONOCLONAL ANTIBODIES AGAINST HUMAN AND MOUSE COLQ


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: STEFANICK, MARCIA  (contact)

PROJECT_TERMS: Aging;Ancillary Study;Cardiovascular Diseases;Cardiovascular system;Classification;cohort;Contracts;Data;Discipline;epidemiology study;Event;follow-up;Funding;Goals;innovation;Knowledge;Life;older women;Participant;platform-independent;power analysis;Prevention trial;Qualifying;Quality of life;Research;Research Personnel;resilience;Resources;sample collection;Women's Health

PROJECT_TITLE: WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: AUGUSTA

ORG_NAME: CHARLIE NORWOOD VA MEDICAL CENTER

ORG_STATE: GA

PHR: Osteoporosis, a major health issue in the elderly, results in hospitalizations and reduced quality of life. Veterans are at increased risk of developing osteoporosis and have worse outcomes than the general population. Kidney function also declines with aging. The kidney contributes to bone health through synthesis and regulation of key factors (Vitamin D, calcium and phosphate) and through renal effect of bone-produced FGF23. Kynurenine, an oxidized tryptophan metabolite, increases with aging, likely as a result of the chronic inflammation and increased oxidative stress observed with age. Although elevated kynurenine levels have been shown to result in decreased bone mass, its impact on the kidney and kidney-bone crosstalk has not yet been explored. The proposed research will examine this relationship, while serving as a platform for the applicant’s career development.

PI_NAMEs: IRSIK, DEBRA  (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Advisory Committees;Advocate;Affect;Age;age related;aged;Aging;aging related;Albuminuria;American;Antioxidants;Aryl Hydrocarbon Receptor;Award;Biology;Blood Pressure;bone;bone aging;Bone Density;bone health;bone loss;Bone Marrow Stem Cell;bone mass;bone metabolism;Calcium;career;career development;Chronic;Collaborations;Communication;cost estimate;Data;Degenerative Disorder;Dietary Intervention;Dihydroxycholecalciferols;Discipline;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Educational process of instructing;Elderly;Essential Amino Acids;Excretory function;Experimental Designs;experimental study;Faculty;feeding;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Fibrosis;Fracture;Funding;General Population;Gerontology;Glomerular Filtration Rate;Goals;Health;Health Care Costs;high risk;Histology;Hormones;Hospitalization;immune cell infiltrate;Impairment;Inflammation;innovation;inorganic phosphate;International;Kidney;kidney dysfunction;kidney fibrosis;Knowledge;Kynurenine;Laboratories;large datasets;Learning Skill;Life;Link;Mediating;meetings;member;Mentors;Mentorship;minority investigator;Mixed Function Oxygenases;Molecular;Morbidity - disease rate;mortality;Mus;Osteoporosis;Outcome;oxidation;Oxidative Stress;Pathway interactions;Phenotype;Positioning Attribute;Premature aging syndrome;Principal Investigator;Process;Protein-Restricted Diet;PTH gene;Public Health;Quality of life;receptor;Regulation;Renal function;Renal glomerular disease;Renal Mass;Research;Research Personnel;Risk;Scientist;Serum;Serum Calcium Level;Signal Transduction;stem cell proliferation;System;tenure track;Testing;Training;Tryptophan;Tryptophan 2,3 Dioxygenase;Underrepresented Minority;Veterans;Vitamin D;Woman;Work;young adult

PROJECT_TITLE: Kynurenine: a potential link between age-related decreases in bone mass and kidney function


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Cranial neural crest cells (CNCCs) are a multipotent population of cells that differentiate into a variety of cell- types including bone, cartilage, and neurons of the craniofacial complex. This proposal will explore the molecular signals that contribute to establishing CNCC potency. Knowledge gained from this proposal could be applied to generate tissues amenable for surgical repair of craniofacial malformations and injury.

PI_NAMEs: HAN, SIMON JOON YOUNG (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Binding;Biological Assay;bone;Cartilage;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cephalic;Cleavage Under Targets and Release Using Nuclease;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;craniofacial repair;Data;Development;directed differentiation;Ectoderm Cell;Embryo;Exposure to;Gene Activation;Gene Expression Profile;gene regulatory network;Genes;Genetic Recombination;Germ Layers;In Vitro;Injury;insight;Knowledge;Mediating;Modality;Molecular;mouse model;Mus;mutant;Neural Crest;Neural Crest Cell;Neuroectoderm;Neuroglia;Neurons;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Patients;Phenotype;pluripotency;Population;prevent;programs;Proteins;Recombinants;Reporting;Repression;Role;SHH gene;Signal Transduction;single cell analysis;single-cell RNA sequencing;Smooth Muscle;smoothened signaling pathway;Specific qualifier value;Study Subject;Testing;Tissues;transcription factor;Transcription Initiation;Western Blotting;Work

PROJECT_TITLE: The role of Sonic hedgehog signaling in cranial neural crest potency

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Arthritis;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Neurosciences;Osteoarthritis;Pain Research

ORG_CITY: STEPHENVILLE

ORG_NAME: TARLETON STATE UNIVERSITY

PHR: Project Narrative Pain is a complex and prolific public health concern faced by more than 100 million Americans. Pain is a multidimensional construct that consists of sensory-discriminative, affective- motivational, and cognitive- evaluative dimensions, yet the EEG profile of the cortical activity that underlies the pain dimensions is not comprehensively understood. We seek to elucidate the fundamental neurobiological and physiological knowledge of pain with a full EEG profile in an experimentally robust study, which is paramount for the development of new treatment strategies that reduce the burden of pain.

PI_NAMEs: HARRIS BOZER, AMBER  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 3-Dimensional;Acute Pain;Address;Affective;American;Anterior;Area;Chronic;chronic pain;cingulate cortex;Cognitive;Complex;Data;Degenerative polyarthritis;design;Development;Dimensions;Disease;Electrodes;Electroencephalography;experience;Female;Frequencies;Image;insight;Insula of Reil;Knee Osteoarthritis;knee pain;Knowledge;Literature;Location;male;McGill Pain Scale;Methodology;Motivation;multidisciplinary;neural;Neurobiology;novel;novel strategies;novel therapeutic intervention;osteoarthritis pain;Outcome;Pain;Pain management;pain processing;Participant;Physiological;Physiology;power analysis;pressure;Public Health;Questionnaires;Reporting;Research;response;Rest;Sample Size;Sampling;Sensory;sensory cortex;sensory stimulus;sex;somatosensory;Somatosensory Cortex;Stimulus;System;systematic review;Thalamic structure;Work

PROJECT_TITLE: Elucidating the neural oscillations of the sensory-discriminative and affective-motivational dimensions of pain.

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative/Relevance Statement Our studies will make important contributions to help clarify the mechanisms of centromere maintenance and specify the role of EWSR1 in centromere function and chromosome segregation, which will lead to insights relevant to health and disease, including cancer, birth defects, and developmental disorders such as Down syndrome.

PI_NAMEs: KITAGAWA, KATSUMI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Auxins;Binding;Biochemical;Cell Cycle;Cell Cycle Stage;Cell division;Cells;Centromere;centromere protein A;Chimeric Proteins;Chromatids;Chromatin;Chromosome Segregation;Chromosomes;Congenital Abnormality;Data;daughter cell;Deposition;developmental disease;Disease;DNA;DNA biosynthesis;DNA Sequence;Down's Syndrome;Engineering;Ensure;Ewings sarcoma;EWSR1 gene;experimental study;FLI1 gene;G1 Phase;Goals;Health;Histone H3;Hybrids;Impairment;insight;Interphase;Kinetochores;Maintenance;Malignant Neoplasms;Mammals;Microtubules;Mitosis;Modeling;Modification;mutant;Mutation;Nucleosomes;Oncogenic;Parents;Phase;Phenotype;Play;prion-like;Publishing;Reporting;Research;RNA;RNA Binding;RNA Recognition Motif;Role;segregation;SETX gene;Signal Transduction;Sister Chromatid;Specific qualifier value;Specificity;Structure;System;Testing;transmission process;Variant;Work

PROJECT_TITLE: The role of EWSR1 at the centromere--


ORG_DEPT: BIOCHEMISTRY

PHR: Emerging evidence from recent genome-wide studies has revealed that promoters across eukaryotes are commonly paired to drive bidirectional transcription. Work in yeast suggests bidirectional transcription could be the naïve or innate state of transcription initiation with directionality evolving due to the action of diverse pathways. Building on our initial success in developing a highly efficient in vitro reconstitution system of transcription initiation from highly purified yeast factors, we set out to further develop this system to solve the mechanism of divergent transcription through structural and biochemical dissection.

PI_NAMEs: MURAKAMI, KENJI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: analytical ultracentrifugation;Biochemical;Complex;crosslink;Cryoelectron Microscopy;Dissection;Eukaryota;Genetic Transcription;genome-wide analysis;In Vitro;Mass Spectrum Analysis;Mediator;Molecular;Pathway interactions;Polymerase;promoter;reconstitution;RNA Polymerase II;Series;success;System;Transcription Initiation;Work;Yeasts

PROJECT_TITLE: Functional and structural studies of the transition from transcription initiation to elongation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: African American women with triple negative breast cancer have much worse clinical outcome, in terms of early relapse, aggressive metastasis and 5-year survival rate of 14% compared to 36% for other races. We have discovered race-specific single nucleotide polymorphism in TRIM37 that strongly correlates with high TRIM37 expression in African American women, and aggressive metastatic phenotype. This project will demonstrate that TRIM37 is a genetic variant associated with high risk of metastatic TNBC in African American women and generate proof-of-concept data to treat metastatic TNBC using TRIM37-specific antisense oligonucleotide and investigational clinical anti-FOLR1 antibody-guided nanoparticles.

PI_NAMEs: BHATNAGAR, SANCHITA  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Affect;African American;African American Women;Alleles;Anoikis;Antibodies;Antisense Oligonucleotides;Artificial nanoparticles;Biological;Brain;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer Treatment;Breast Epithelial Cells;cancer cell;cancer health disparity;cancer predisposition;cancer subtypes;Caucasians;causal variant;Cell Line;Circulation;Clinical;clinically relevant;comorbidity;CRISPR screen;Data;Data Set;Death Rate;Dependence;Development;Disease;Disparity;disparity reduction;Distant;efficacy evaluation;Engineering;Epigenetic Process;ethnic diversity;Ethnic Origin;experience;folate-binding protein;FOLR1 gene;Functional dependence;Gene Expression Profile;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;Genetic Risk;Genetic Transcription;genetic variant;Genome;Genotype;Goals;Growth;Head Start Program;health care availability;health care disparity;high risk;In Vitro;in vivo;in vivo Model;Incidence;Infiltration;innovation;Legal patent;Link;Liver;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Molecular Target;mouse model;nanoparticle;Neoplasm Metastasis;novel;Oncogenic;Oncoproteins;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phase I Clinical Trials;Phenotype;Predisposition;Prognosis;Prognostic Marker;programs;prospective;Proteins;Quantitative Trait Loci;Race;racial disparity;Racial Segregation;rational design;Relapse;Resistance;Risk;Single Nucleotide Polymorphism;Site;survival outcome;Survival Rate;Susceptibility Gene;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;treatment disparity;TRIM Motif;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;Tumor Tissue;Variant

PROJECT_TITLE: TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Huntington's Disease;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE All cells encounter replication barriers upon genome duplication, and must overcome those barriers to restart replication. Failure to restart the replication process leads to chromosome breaks and mutations, as occurs in cancer cells under replication stress. Successful completion of the experiments proposed will significantly enhance our understanding of replication and the genetic pathways that normally prevent disease-causing mutations and cancer initiation.

PI_NAMEs: FREUDENREICH, CATHERINE H (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Back;base;Biochemical;CAG repeat;cancer cell;cancer initiation;Cell Nucleus;Cell Physiology;Cells;Chromosomal Breaks;Chromosome Breakage;Chromosome Deletion;chromosome mutation;Data;Disease;disease-causing mutation;DNA;DNA replication fork;DNA Structure;Elements;experimental study;Failure;G2 Phase;Genetic;Genome;Genome Stability;Genomic Instability;Goals;Human;Human Genome;Huntington Disease;Laboratories;Location;Microsatellite Repeats;Microscopy;Modification;Mutation;Myotonic Dystrophy;novel strategies;Nuclear;Nuclear Pore Complex;Pathway interactions;Post-Translational Protein Processing;prevent;Prevention;Proteins;Proteome;repaired;replication stress;Replication-Associated Process;Role;S phase;Saccharomyces cerevisiae;Saccharomycetales;Short Tandem Repeat;Spinocerebellar Ataxias;Structure;Sumoylation Pathway;System;Techniques;yeast genetics;yeast genome;Yeasts

PROJECT_TITLE: Replication through DNA Structures and Consequences for Genome Stability


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE A specialized subset of B lymphocytes, termed regulatory Bregs, can inhibit immune responses to a foreign transplant. We plan a series of experiments to help understand the mechanisms by which Bregs act to prevent rejection of organ and tissue transplants and how they can be applied safely and successfully as a cellular therapy.

PI_NAMEs: MARKMANN, JAMES FRANCIS (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adoptive Transfer;allograft rejection;anti-CD20;Antibodies;Antigen Presentation;Antigen Targeting;Antigens;Area;ARHGEF5 gene;arm;Autoimmunity;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Biological Markers;Blood;Bone Marrow;Cell Communication;Cell Therapy;Cell Transplantation;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Research;Comparative Study;Critical Pathways;cytokine;Data;Development;early phase clinical trial;Endowment;Engineering;Environment;Exhibits;Experimental Models;experimental study;Flow Cytometry;Funding;Future;gene therapy;Generations;Goals;Graft Rejection;Graft Survival;Hematologic Neoplasms;humoral immunity deficiency;Hypersensitivity;IL2RA gene;Immune response;immunoregulation;Immunosuppression;In Vitro;in vivo;innovation;Innovative Therapy;interest;Interleukin-10;Investigation;islet;Islets of Langerhans Transplantation;kidney allograft;Kidney Transplantation;lipid nanoparticle;liver allograft;Location;Lymphocyte;Malignant Neoplasms;Medicine;Modeling;Monitor;Monoclonal Antibodies;mRNA Expression;mRNA lipid nano particle vaccine;Mus;novel;organ transplant rejection;Ovalbumin;Pathway interactions;pharmacologic;Phenotype;Population;premature;prevent;Process;programmed cell death ligand 1;Property;receptor;Refractory;Regulatory T-Lymphocyte;response;Rest;Role;Series;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Skin Transplantation;Specificity;standard of care;stem cells;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technology;Therapeutic;Tissue Grafts;Tissue Transplantation;Tissues;TNF gene;TNFRSF5 gene;Toll-like receptors;transcriptomic profiling;Transforming Growth Factor beta;translational potential;Translations;transplant model;Transplantation;Transplantation Tolerance;vaccine delivery;vaccine development;Validation;Work

PROJECT_TITLE: Mechanisms of action, optimization and application of Bregs

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Autoimmune Disease;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative With growing use of patient sequencing to diagnose Autoimmune Polyendocrine Syndrome Type 1 (APS-1), a rare disease caused by damaging variants in the autoimmune regulator gene (AIRE), the need to better interpret pathogenicity of rare sequence variants has also grown. Functional assays are one of the strongest forms of evidence for variant interpretation according to current guidelines, but such testing is generally reactive, as variants are first seen in the clinic, and results often arrive months or years after. Instead, we propose to proactively evaluate every missense variant of AIRE, yielding a proactive sequence-function map to enable more accurate clinical interpretation of AIRE missense variants.

PI_NAMEs: ROTH, FREDERICK P (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: accurate diagnosis;Addison's disease;Adrenal Glands;Amino Acids;assay development;Asthma;Atlases;Autoimmune;Autoimmune Diseases;Autoimmune Polyendocrinopathies;Autoimmunity;autoreactive T cell;Biochemical;Biological Assay;Candidiasis;Cells;cellular engineering;Childhood;Chronic Mucocutaneous Candidiasis;Classification;Clinic;Clinical;ClinVar;cohort;Collaborations;common symptom;congenital immunodeficiency;Cultured Cells;Diagnosis;Diagnostic;Disease;disease diagnosis;disease-causing mutation;Early Diagnosis;Endocrine;Genetic;Genetic Databases;genetic disorder diagnosis;genetic variant;Genomics;Guidelines;Health;Human;Hypoparathyroidism;Impairment;improved;insight;Insulin;interest;Letters;Lung;Maps;Molecular;next generation sequencing;Pathogenicity;patient prognosis;Patient-Focused Outcomes;Patients;Phenotype;Polyglandular Autoimmune Syndrome Type I;prevent;Process;promoter;protein structure;Proteins;Provider;Publishing;pulmonary function;Pulmonary Inflammation;rapid diagnosis;Rare Diseases;rare variant;Regulator Genes;Reporter;Reporting;Resources;Risk;Severities;Structure;Symptoms;T-Lymphocyte;Testing;Time;Tissue-Specific Gene Expression;tool;transcriptome;Variant;variant of unknown significance;Work

PROJECT_TITLE: A Proactive Missense Variant Atlas for the Autoimmune Regulator

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


PHR: RELEVANCE (See instructions): The foundations built in this project will enable reliable ways to directly lead to the meaningful interpretation of the hidden information buried in genomic and proteomic sequences. Predicting compensatory mutations, where mutations in one part of a protein compensate for damaging mutations in other parts will likewise provide a rational basis for gene editing, as well as understanding of evolution. This ambitious project aims to broadly identify which gene mutations are damaging and how to counteract their effects with the new unique open-source computational tools.

PI_NAMEs: REN, ZHAO  (contact)

PROJECT_TITLE: An effective statistical inference framework to develop innovative compensations for protein mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-A (BM)]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on identifying mechanisms of detection, resistance and co-option of three food-borne toxins of medical importance: isothiocyanates, cardiac glycosides and cytolethal distending toxins. Although these toxins cause human illness, each is also being used or is in development for treatment of common and debilitating diseases, including Parkinson’s disease, congestive heart failure, and cancer. The proposed research is relevant to that part of the NIH mission that pertains to seeking fundamental knowledge about the nature and behavior of living systems and to that part of the NIGMS mission that supports basic research toward understanding how living systems function across levels of biological organization, from molecules, to cells, tissues, individuals and populations.

PI_NAMEs: WHITEMAN, NOAH K (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Aloral;Animal Model;Animals;base;Basic Science;Behavior;Biological;Biology;Butterflies;Cardiac Glycosides;Cells;common treatment;Congestive Heart Failure;CRISPR/Cas technology;cytolethal distending toxin;Detection;Development;Disease;Drosophila melanogaster;Evolution;flexibility;fly;foodborne;gene editing technology;Genes;Genetic;Genetic Models;genome-wide;Genomics;Goals;Human;Immune;Immune system;in vivo;Individual;interest;Isothiocyanates;Knock-in;Knowledge;Malignant Neoplasms;Mediating;Medical;Mission;Modeling;Mouse-ear Cress;mustard oil;Mutation;National Institute of General Medical Sciences;Natural Selections;Nature;Odorant Receptors;Organism;Parasite resistance;Parasites;parasitism;Parkinson Disease;Pattern;Phase;Plant Model;Population;Process;Proteins;Public Health;Research;Resistance;Shapes;System;therapy development;Tissues;Toxin;transmission process;United States National Institutes of Health;Variant;Volatilization;Walking

PROJECT_TITLE: Co-evolutionary Genetics of Host-Parasite Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The kinesin superfamily of motor proteins orchestrates various cellular processes, necessitating careful control of kinesin activity. This project will determine the molecular details underlying kinesin inhibition via kinesin binding protein and kinesin light chain and provide a framework to understand how kinesin-driven cargo transport is regulated.

PI_NAMEs: CIANFROCCO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Axonal Transport;Binding;Binding Proteins;Cell division;Cell Physiology;Cells;Complex;crosslink;Cryoelectron Microscopy;Environment;Equipment;Grant;Kinesin;Lead;Length;Light;Mass Spectrum Analysis;Mediating;Microtubules;Mitotic spindle;Modeling;Molecular;Motor;mutant;novel;Organelles;Patients;Positioning Attribute;Protein Engineering;Protein Inhibition;Proteins;Regulation;Site-Directed Mutagenesis;spatiotemporal;Work

PROJECT_TITLE: Mechanisms of kinesin motor protein inhibition: Equipment Supplement


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The Johns Hopkins CERSI (JH-CERSI) represents a highly innovative collaboration between the world’s leading regulatory authority and the country’s largest research university. In this renewal, we combine the remarkable success of JH-CERSI since its inception with three new elements to accelerate knowledge and enhance impact in areas of incredibly high regulatory importance. There is not a moment to lose.

PI_NAMEs: ALEXANDER, G. CALEB (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Johns Hopkins Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Rehabilitation;Telehealth

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans, and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and self- management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies – one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, the other involving telephonic peer coaching – to enhanced usual care, and to each other, at increasing patient participation in PR after an exacerbation.

PI_NAMEs: LINDENAUER, PETER KYLE (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: acute care;Adopted;Adult;Affect;American;Attitude;Behavior;behavior change;blood pressure control;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;cohort;compare effectiveness;cost;Development;Disease Management;Dyspnea;Effectiveness;effectiveness evaluation;Eligibility Determination;Emergency department visit;exercise program;Goals;Guidelines;Health;Hospitalization;Hospitals;improved;Individual;Infrastructure;Intervention;Lead;Leadership;Libraries;Lived experience;Methods;mortality;Narration;National Heart, Lung, and Blood Institute;novel strategies;Patient Participation;Patients;peer;peer coaching;peer support;Phase;Physicians;programs;Protocols documentation;pulmonary rehabilitation;Quality of life;Randomized;Recommendation;Recovery;recruit;Recurrence;Research;Self Management;Shortness of Breath;Structure;Techniques;Telephone;Training;treatment as usual

PROJECT_TITLE: Improving Participation in Pulmonary Rehabilitation through Peer-Support and Storytelling


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PI_NAMEs: SQUARE, TYLER  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Adult;Area;Automobile Driving;Basic Science;Body Regions;Candidate Disease Gene;candidate identification;cell type;Cities;Code;Competence;Congresses;Country;County;Data;deciduous tooth;Dental;Development;ectodysplasin;Elements;Event;Exhibits;experimental study;Face;Fishes;Future;Gasterosteidae;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Family;Genes;Genetic;Genetic Determinism;genetic signature;Genetic Transcription;Goals;Grant;Growth;Head;Human;Implant;Individual;insight;Instruction;Location;Mammals;Mentors;Mesenchyme;Microdissection;Modeling;Morphogenesis;Morphology;Motion;mRNA sequencing;Mus;mutant;Mutant Strains Mice;Names;Natural regeneration;neuromast;Organ;overexpression;Pathway interactions;Pattern;Pattern Formation;performance site;Periodicity;Phase;Phenotype;Positioning Attribute;Process;Province;receptor;regeneration potential;regenerative;Reproducibility;Research;response;Sensory;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;Specific qualifier value;Taste Bud Cell;Taste Buds;Testing;Tissues;tool;Tooth Germ;Tooth regeneration;Tooth structure;Transcript;Transgenic Organisms;Tumor Necrosis Factor Receptor;Vertebrates;wisdom tooth;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Identification of the factors underlying tooth field size and competency

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: EAU CLAIRE

ORG_NAME: UNIVERSITY OF WISCONSIN EAU CLAIRE

ORG_STATE: WI

PHR: Public Health Relevance Statement The field of neuroscience and regenerative sciences needs ongoing innovation to address the challenges of understanding brain function and brain-related disorders. The University of Wisconsin Eau Claire – Mayo Clinic Regenerative Neuroscience Scholars (ReNS) Program enables undergraduates to obtain high-quality training in regenerative neuroscience research. Using innovative and coordinated approaches in recruitment, research, curriculum, and mentoring, this program will prepare students for success in careers in research and Ph.D. training in neuroscience and regenerative sciences.

PI_NAMEs: CARTER, BRADLEY S (contact);SCARISBRICK, ISOBEL A

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Advisory Committees;Agreement;Brain;career;career development;Clinic;cohort;Color;Development;disabled students;Disease;Diverse Workforce;Doctor of Philosophy;Educational Curriculum;educationally disadvantaged;experience;Faculty;Fellowship Program;Goals;graduate student;innovation;Institution;Interview;Laboratories;Mentors;Neurosciences;Neurosciences Research;peer coaching;Postbaccalaureate;programs;prospective;Publications;recruit;regenerative;Relationship-Building;Research;Research Personnel;Research Training;role model;Scholars Program;Science;Scientist;skills;skills training;socioeconomic disadvantage;STEM career;Students;success;summer research;symposium;Thinking;Training;Training Support;undergraduate research;undergraduate research experience;undergraduate student;Universities;Videoconferencing;Wisconsin

PROJECT_TITLE: University of Wisconsin Eau Claire-Mayo Clinic Regenerative Neuroscience Scholars (ReNS) Program-AdminSppl


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This section is not required per PA-23-189 nor the NHLBI Research Supplement Application Guidelines.

PI_NAMEs: CHI, NEIL C;FREIBERG, MATTHEW S;HSUE, PRISCILLA Y. (contact);NATARAJAN, PRADEEP

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adjudication;Age;Aging;antiretroviral therapy;Atherosclerosis;Biological Markers;biomarker evaluation;Blood Cells;Cardiovascular Diseases;cardiovascular disorder risk;cell type;Cells;Chromosome abnormality;Chronic;Chronic Disease;Clinical;Clonal Expansion;cohort;Cohort Studies;Communicable Diseases;Data;Department of Defense;Development;epigenomics;Evaluation;Event;General Population;Genes;Guidelines;Hematopoiesis;Hematopoietic;High Prevalence;HIV;HIV Infections;Immune;immune activation;immune function;immunomodulatory therapies;Individual;Inflammation;inflammatory marker;Interleukin-1 beta;Interleukin-6;mortality;mosaic;Mutation;National Heart, Lung, and Blood Institute;novel;novel marker;Outcome;parent grant;Pathologic;Pathway interactions;Persons;Play;Population;premature;programs;prospective;Research;Risk;Risk Factors;Role;System;Veterans;Viral reservoir

PROJECT_TITLE: Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: BAKER, DAVID  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;Affinity;algorithm development;Algorithms;Alleles;Antibodies;Antigen Presentation;Antigen Targeting;Antigen-Antibody Complex;Antigens;atomic data;Benchmarking;Binding;Biochemical;cancer therapy;cancer type;Code;combinatorial;Complex;Computer Models;Computing Methodologies;cytotoxicity;Data;Data Set;design;Development;Engineering;Event;extend lifespan;Face;FDA approved;Feedback;Generations;Goals;Grant;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;Individual;insight;Institution;interest;large datasets;large scale data;Libraries;Link;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Melanoma;method development;Methods;Modeling;Molecular;monomer;mouse model;Mutagenesis;next generation;novel drug class;Output;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;Probability;protein complex;Protein Engineering;Proteins;quantum;Reagent;receptor binding;Research Personnel;response;Rest;Site;Source;Specificity;structural biology;Structure;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-cell diversity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy design;three dimensional structure;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Universities;Vision;Washington;Work

PROJECT_TITLE: MATCHMAKERS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Little is known about the growth trajectories of brain development across the first 24-months of life because of  insufficient approaches to analyze infant MRI scans especially brain segmentation. This proposal leverages  artificial intelligence and large-scale datasets to address unmet technical challenges in infant brain segmentation,  to delineate the growth trajectories of brain structure/function and measure their relationship with  neuropsychological functions, and to predict the developmental outcomes. Results from this study will address  fundamental methodological limitations and fill critical knowledge gaps of early development, advancing efforts  toward early identification of developmental delays and disorders.

PI_NAMEs: WANG, YUN  (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: 3 year old;Address;Adopted;Age;Anxiety;Applications Grants;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Artificial Intelligence platform;Attention deficit hyperactivity disorder;automated segmentation;Automobile Driving;Behavior;Birth;Birth Weight;Black Box;Brain;brain based;brain magnetic resonance imaging;Brain region;career;Clinical;clinical application;Cognition;cognitive ability;cognitive development;cohort;Collaborations;Comprehension;connectome;convolutional neural network;Data;data preservation;data privacy;Data Set;detection method;Development;Developmental Delay Disorders;developmental disease;Developmental Process;early detection biomarkers;Early Diagnosis;Early identification;emotional functioning;Ethnic Origin;executive function;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Gestational Age;Growth;Human;Image;improved;Individual;infancy;Infant;innovation;Institution;Knowledge;Language;large scale data;Learning;Life;long short term memory;Magnetic Resonance Imaging;Measures;Mental Depression;Mental disorders;Methodology;Methods;Modality;Modeling;MRI Scans;multimodality;Neonatal;neuroimaging;Neuropsychology;Neurosciences;novel;Outcome;Outcome Assessment;Participant;Phase;Principal Component Analysis;Problem behavior;Race;rapid growth;Reproducibility;Research;Research Personnel;Resolution;Rest;Sample Size;Sampling;Scanning;sex;Shapes;social;Structure;Symptoms;Time;Toddler;tool;Validation;virtual

PROJECT_TITLE: Leveraging artificial intelligence to develop novel tools for studying infant brain development


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: KING'S COLLEGE LONDON

ORG_ZIPCODE: WC2R 2LS

PI_NAMEs: BELL, JORDANA ;SPECTOR, TIM  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Adverse effects;Age;Animal Model;anti-cancer research;Biological;Biological Factors;Biological Models;cancer initiation;Cells;cohort;Collaborations;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Computational Biology;Data;Development;Diet;dietary;Dimensions;Discipline;early onset;early onset colorectal cancer;Ecosystem;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Etiology;Generations;Genetic;Genomics;Goals;high risk;Homeostasis;Immunology;Incidence;Individual;individualized prevention;innovation;Intervention;Lesion;Life Cycle Stages;life span;Life Style;lifestyle intervention;Link;Malignant Neoplasms;Mind;Modeling;Molecular;molecular marker;Motivation;novel;Pathway interactions;pharmacologic;Population;Positioning Attribute;prevent;Prevention;Prevention strategy;Process;prospective;Research;Resolution;Risk;Risk Assessment;Risk Factors;small molecule;social determinants;stem cell biology;Technology;Tissues;Translating;Vision;Work;young adult

PROJECT_TITLE: PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Horizontal gene transfer, which refers to the direct transfer of genetic material between bacterial cells, is an important way that pathogens evolve and has been implicated in a wide variety of infectious diseases. However, we don’t yet fully understand how different genetic and environmental factors influence the overall success and consequences of gene transfer events, especially in the time window immediately after these events occur. This proposal uses both computational and experimental methods to tease apart these relationships; ultimately, we hope to be able to predict high-risk gene transfer (e.g., to new/emerging pathogens) before it occurs, thereby allowing us to explore novel control and treatment strategies.

PI_NAMEs: LOPATKIN, ALLISON  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic Therapy;Bioinformatics;Bioremediations;Cells;Clinical;clinically relevant;Communicable Diseases;Computer Models;cost;Distant;driving force;emerging pathogen;Environment;Environmental Risk Factor;Epidemiologic Monitoring;Event;Evolution;experimental study;fitness;Gene Transfer;Genetic;Genetic Materials;Geography;Goals;Health;high risk;Horizontal Gene Transfer;Human;In Situ;Individual;Industrialization;insight;Mediating;Metabolic;Methods;microbial;microbiome research;Minority;Mission;Molecular;Multi-Drug Resistance;National Institute of General Medical Sciences;novel;Partner in relationship;pathogen;Pathogenesis;Plasmids;Population;Prevalence;Process;programs;Research;resistance gene;success;Time;trait;treatment strategy;Virulence;Work

PROJECT_TITLE: Determinants underlying horizontal gene transfer-mediated pathogen success


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Many serious complications associated with pregnancy, like placenta accreta or placental insufficiency, happen when the placenta from the baby either grows too deep, or too shallow into the mother’s uterus posing serious risk to the mother’s life. I will study the how the cells from the fetus and the mother “talk” to each other, controlling how deeply the placenta attaches, to find ways to limit these complications without surgery.

PI_NAMEs: SUHAIL, YASIR  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Back;Bioinformatics;Biological Assay;Biomedical Engineering;career;Computational Biology;Data;Disease Outcome;Endometrial;Endometrium;experience;feeding;Fetal Diseases;Fetal Growth Retardation;fetus cell;Fibroblasts;Genes;Genomics;Genotype;Health;Human;Hysterectomy;In Vitro;Informatics;Interleukin-11;Interstitial Collagenase;Invaded;Investigation;Life;Mammals;Maps;mathematical model;Mathematics;Melanoma;Mentors;Methodology;Methods;Modeling;Molecular;Mothers;Operative Surgical Procedures;paracrine;Patients;Phase;Phenotype;Placenta;Placenta Accreta;Placental Insufficiency;Pre-Eclampsia;Pregnancy;Production;Recording of previous events;Regulation;Research;Risk;Role;Sampling;Signal Transduction;Skin;Stromal Invasion;Symptoms;Systems Biology;technology platform;Theoretical model;Tissues;Training;trophoblast;Uterus;Validation;Variant;Villous;Work

PROJECT_TITLE: Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal diseases


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed work is relevant to public health and to the mission of the National Institute of Dental and Craniofacial Research to reduce inequality in oral health care, because it evaluates the impact of addressing adverse social determinants of health on patients’ ability to access oral health care. This supplement builds on our current work, exploring how geographically-proximate resources and navigational assistance moderate aSDoH and oral health outcomes, and what barriers remain.

PI_NAMEs: SAMUELS-KALOW, MARGARET EMILY (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Communities;Disparity;effectiveness/implementation study;Emergency Care;Ensure;Geography;Goals;Healthcare;implementation strategy;Inequality;insight;Interdisciplinary Study;Intervention;Intervention Trial;Knowledge;Methods;Mission;Modeling;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral health;Outcome;participant enrollment;Patients;Public Health;Randomized, Controlled Trials;Resources;Risk;screening;social;social health determinants;Strategic Planning;System;Vulnerable Populations;Work

PROJECT_TITLE: Mixed Methods Supplement for the MOLAR study


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Aneuploidy, the state of having too many or too few chromosomes, is a leading cause of developmental diseases, miscarriages, and failed pregnancies using assisted reproductive technology. To prevent aneuploidy, the cell has many ways of ensuring chromosomes segregate correctly, one of which is to create crossovers between homologous chromosomes. The goal of this grant is to determine how crossovers are made and how variations in genome structure impact crossover formation.

PI_NAMEs: CROWN, KIMBERLY NICOLE (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Aneuploidy;Assisted Reproductive Technology;Cells;Chromosome inversion;Chromosome Segregation;Chromosomes;Computer software;Data;Defect;developmental disease;Drosophila genus;Drosophila melanogaster;Ensure;Equipment;Event;Failure;Funding;Genetic;Genetic Recombination;Genome;genome-wide;Goals;Grant;Heterozygote;Homologous Gene;Image Analysis;insight;instrument;Knowledge;light microscopy;Maintenance;Mediating;Meiosis;Methods;Microscope;Modeling;Organism;parent grant;pregnancy failure;prevent;programs;repaired;reproductive;reproductive success;response;Spontaneous abortion;Structure;Synaptonemal Complex;Synteny;System;Training;Variant

PROJECT_TITLE: Chromosome structural variants in meiosis - Equipment supplement


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: KEENE

ORG_NAME: KEENE STATE COLLEGE

ORG_STATE: NH

PHR: The recent increase in the Internet of Medical Things (IoMT) has revolutionized healthcare, but it has also introduced critical security and privacy challenges. Our research presents a groundbreaking explainable artificial intelligence (XAI) based hybrid intrusion detection system for IoMT devices, combining formal threat analysis model-based misuse detection and machine learning algorithms for anomaly detection. This comprehensive study will not only safeguard against cyber threats but also improve healthcare delivery and patient trust in medical technology by providing transparent, understandable, and actionable explanations of the machine learning model-based decisions.

PI_NAMEs: LU, WEI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Administrator;artificial intelligence algorithm;Behavior;Blood Glucose;Bypass;Caring;Certification;Cloud Computing;Communication;Complex;Computer Security;Computer software;cost;cyber security;Data;data privacy;Dedications;design;Detection;detection platform;detector;Devices;digital health;Disclosure;effectiveness validation;encryption;Ensure;Equilibrium;Evaluation;explainable artificial intelligence;Face;flexible electronics;glucose monitor;Growth;Guidelines;health care delivery;health data;Health Personnel;Health Services;Healthcare;Healthcare Industry;Hospitals;Hybrids;Implantable Defibrillators;improved;Infrastructure;interdisciplinary collaboration;Internet of Medical Things;Internet of Things;intrusion detection system;Life;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction algorithm;Magnetic Resonance Imaging;man;manufacture;Medical;Medical Device;medical information system;Medical Technology;Memory;Methods;Modeling;Monitor;Network Infrastructure;neural network;novel;Operating System;Outcome;Paper;patient safety;Patients;Personal Satisfaction;power consumption;Prevention;Primary Prevention;Privacy;programs;Protocols documentation;provider networks;Qualifying;remote health care;remote monitoring;Research;Research Personnel;Resources;Risk;Security;Security Measures;sensor;Services;Shapes;Source;System;Technology;Testing;Time;Training;Trust;trustworthiness;undergraduate student;United States Dept. of Health and Human Services;Vendor

PROJECT_TITLE: An Explainable Artificial Intelligence Based Hybrid Intrusion Detection System for Enhancing Healthcare Security

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Lung

ORG_NAME: OAKLAND UNIVERSITY

PHR: PROJECT NARRATIVE The development of non-invasive diagnostic tools to characterize the microstructure of thrombi (i.e., blood clots) is critical to the selection of proper treatment and clinical pathways for many cardiovascular diseases including stroke, ischemic heart disease, and venous thromboembolism. Driven by primarily undergradu- ate researchers, we will characterize the unique optical properties of biological chromophores relevant in thrombosis and develop algorithms to quantitatively measure thrombus composition using photoacoustic imaging. These tools will ultimately lead to targeted thrombosis treatment, resulting in rapid determination of treatment path and ultimately improved patient outcomes.

PI_NAMEs: WIACEK, ALYCEN  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: absorption;Acoustics;Acute;Advanced Development;Age;Algorithms;Angiography;Biological;Biological Markers;Blood;Blood coagulation;Blood flow;Blood Platelets;Cardiovascular Diseases;Cause of Death;Cessation of life;chromophore;Chronic;Clinical Pathways;Coagulation Process;Complement;Complex;Coronary heart disease;Deep Vein Thrombosis;Development;Diagnosis;diagnostic tool;Doppler Ultrasound;Emerging Technologies;Erythrocytes;Excision;experimental study;Fibrin;Fibrinogen;Foundations;Hemoglobin;Human;imaging biomarker;imaging modality;imaging properties;improved;in silico;Ischemic Stroke;Light;Literature;Lung;Lung Perfusion Scan;Measurement;Measures;Mentors;Methods;Modeling;Monitor;Myocardial Ischemia;noninvasive diagnosis;optical spectra;Optics;Outcome;Pathology;patient variability;Patient-Focused Outcomes;photoacoustic imaging;Physiologic pulse;Property;Pulmonary Embolism;Qualitative Methods;quantitative ultrasound;rapid diagnosis;rapid technique;Research;Research Personnel;response;restoration;Signal Transduction;Spectrophotometry;Stroke;Structure;targeted treatment;Techniques;Testing;Thrombin;Thrombosis;Thrombus;Time;Tissue imaging;Tissues;tool;Ultrasonography;ultrasound;undergraduate research;undergraduate student;Universities;venous thromboembolism;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative Photoacoustic Imaging Biomarkers for Characterization of Thrombosis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: WASHINGTON

ORG_NAME: HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE

ORG_STATE: DC

PHR: Title: Nitrosamines Forum for Advancing Critical Translational Science (NA FACTS) FOA Title & Number: Identification and Evaluation of Possible Approaches to Addressing Nitrosamine Impurities in Drugs (U01), RFA-FD-24-020 Project Narrative To address the ongoing public health risk from nitrosamines impurities in human drugs, the Health and Environmental Sciences Institute, through the Nitrosamines Forum for Advancing Critical Translational Science (NA FACTS), will form two advisory teams each with distinct tasks. One advisory team will (a) identify, prioritize and prepare a report with recommendations on research priorities for assessment of NA impurities in drugs, (b) initiate a select number of new projects within the Nitrosamines Research Program, and (c) ensure research priorities continue to be addressed beyond the cooperative agreement. A second advisory team will convene a workshop and publish a report on the feasibility of and the mechanisms and resources needed to establish a public-facing (Q)SAR database that builds on NA classification.

PI_NAMEs: JIANG, CONNIE L (contact)

PROGRAM_OFFICER_NAME: WILSON, FELECIA

PROJECT_TITLE: Nitrosamines Forum to Advance Critical Translational Science (NA FACTS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (01)]


ADMINISTERING_IC: AR

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Immunotherapy;Neurosciences;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Volumetric Muscle Loss (VML) is a pervasive clinical challenge with poor functional outcomes and long-term pain even after gold standard autograft treatment. In the parent grant, we propose to develop novel immunomodulatory and regenerative therapies to promote functional muscle regeneration after VML injruies. The overall goals of this Research Supplement to Promote Diversity in Health-Related Research are to: 1) train an exceptional neuroscience graduate student to integrate fundamental peripheral nerve and pain principles with regenerative engineering and musculoskeletal research, 2) evaluate changes in pain, sensory neurons and immune mechanisms of pain after VML, and 3) assess the therapeutic potential of immunomodulatory and stem cell therapies to reduce long term pain after VML.

PI_NAMEs: WILLETT, NICK J (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Afferent Neurons;allodynia;Anabolism;Autologous Transplantation;Award;Behavioral;Biocompatible Materials;career;career development;Cells;chronic musculoskeletal pain;chronic pain;Clinical;Clinical Treatment;Data;Development;Development Plans;Educational workshop;Engineering;Evaluation;fabrication;Filament;Flow Cytometry;Foundations;functional outcomes;Goals;graduate student;Grant;Health;Histology;Immune;immunoengineering;immunomodulatory therapies;immunoregulation;Inflammation;Injury;injury and repair;Limb structure;lipid mediator;lipidomics;Macrophage;Measurement;Measures;Modeling;monocyte;Mus;Muscle;muscle regeneration;Musculoskeletal;musculoskeletal injury;Natural regeneration;nerve supply;Neurologic;Neurosciences;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Outcomes Research;Pain;Pain Measurement;parent grant;Patient observation;Patients;Peripheral Nerves;peripheral pain;pre-clinical;Regenerative engineering;regenerative therapy;regenerative treatment;Research;research and development;response;Role;sensory mechanism;Spinal Ganglia;Stains;stem cell therapy;symposium;T-Lymphocyte;Tactile;Therapeutic;Training;Translating;treatment strategy;TRPV1 gene;volumetric muscle loss;Weight-Bearing state;Work

PROJECT_TITLE: Engineering the Immune and Fibrotic Response in Volumetric Muscle Loss


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This intramural/extramural BtB project studies the role of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) in mouse models of human retinal disease. Dr. Alan Remaley from NHLBI is the PI. An extramural portion of this project will be performed in Dr. Paul Bernstein’s laboratory at the Moran Eye Center of the University of Utah as a supplement to his R01 1R01EY034497-01.

PI_NAMEs: BERNSTEIN, PAUL STEVEN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acids;Acute;Age;age related decline;Age related macular degeneration;Aging;Agonist;Agreement;Anti-Inflammatory Agents;Apolipoprotein E;Atherosclerosis;Basic Science;bench to bedside;Biological Availability;Blindness;Blood Tests;Brain;Carbon;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;Case/Control Studies;Cell Culture System;Cells;chemical synthesis;Clinical;Clinical Chemistry;Clinical Trials;cohort;conditional knockout;Consumption;design;Dietary intake;Dietary Supplementation;dietary supplements;Disease;docosapentaenoic acid;Dose;Enzymes;Extramural Activities;eye center;Fatty Acids;Fish Oils;Fishes;Future;G-Protein-Coupled Receptors;Gas Chromatography;Glucose;glucose and insulin clamps;Health;healthy volunteer;Hepatic;Heterozygote;Human;human model;improved;Insulin;insulin sensitivity;Intervention;knock-down;Knock-out;Knockout Mice;Laboratories;Lead;Length;Lipids;Liver;Macular degeneration;Male Infertility;Manufacturer;Measures;Methylation;Monitor;mouse model;Muscle;Mutation;National Heart, Lung, and Blood Institute;Norway;novel;Nutritional Support;old mice;oxidation;Pathogenesis;Patients;Peroxisome Proliferator-Activated Receptors;Plasma;Play;Polyunsaturated Fatty Acids;Process;Production;promoter;Randomized;Reporter Genes;Research Design;Research Personnel;Retina;Retinal Degeneration;Retinal Diseases;Risk Factors;Role;Safety;Sampling;Signal Pathway;Spermatogenesis;Spinocerebellar Ataxias;Stargardt's disease;Supplementation;Testing;Testis;Tissues;transcriptome sequencing;Universities;Utah;Vision;young adult

PROJECT_TITLE: Elucidating the Role of Very-long-chain Polyunsaturated Fatty Acids in Retinal Health and Disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This section is not required per PA-23-189 nor the NIAID Research Supplement Application Guidelines.

PI_NAMEs: ERNST, JOEL D. (contact);FENG, CARL GUANGDA

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Animal Model;Architecture;Biology;Cells;Data;data integration;Dissociation;Flow Cytometry;Granuloma;Guidelines;Human;human data;Human Pathology;Immune;improved;insight;Interferon Type I;Interferon Type II;Knowledge;Label;live cell imaging;lung injury;lung repair;Macaca mulatta;Modification;Mouse Strains;Mus;National Institute of Allergy and Infectious Disease;Necrosis;Outcome;parent grant;pathogen;Pathologic;Persons;Population;Research;Role;Sampling;spatial relationship;System;therapy development;trafficking;transcriptomics;Treatment outcome;Tuberculosis;tuberculosis granuloma

PROJECT_TITLE: Functional dynamics of TB granuloma architecture - Diversity Supplement for Kelley J. Martinez


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY

ORG_STATE: NC

PHR: Narrative Document not needed: Not Applicable

PI_NAMEs: KING, S BRUCE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Anabolism;Antibiotics;Bacillus anthracis;Bacillus subtilis;Back;Biochemical;Biochemistry;Biology;Chemicals;Chemistry;Chromatography;cofactor;Cysteine;design;Development;Environment;Enzymes;experience;experimental study;Generations;Goals;Gram-Positive Bacteria;Growth;Health;Human;Hydrogen Sulfide;Impairment;In Vitro;in vivo;Incubated;inhibitor;Institution;Investigation;Iron;Measures;Mentors;Metabolism;methicillin resistant Staphylococcus aureus;Methods;microbial;Microbial Physiology;model organism;Modification;Molecular;Molecular Weight;Mycobacterium tuberculosis;Natural Products;Nitric Oxide;Nitrogen;nitroxyl;Outcome;Oxidation-Reduction;Pathogenicity;Pathway interactions;persulfides;Phenotype;Physiology;Principal Investigator;Production;Proteins;Publishing;Reaction;Reactive Oxygen Species;Records;Recycling;Research;response;Role;Sodium Chloride;Source;Stress;Sulfate;Sulfhydryl Compounds;Sulfur;Sulfur Metabolism Pathway;System;Training;undergraduate student;Vitamins

PROJECT_TITLE: Adminstrative Supplement-Chemical Biology of Nitroxyl (HNO) in Bacillus Subtilis