ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: The polarized development and organization of stereociliary bundles on sensory hair cells of the inner ear underlies the detection of sound and motion, and vestibular hair cell function is important for maintaining balance and posture. This project is designed to determine how stereociliary bundle polarity is established during inner ear development and how hair cells are organized within the utricle and saccule so that that individual sensory organs can detect linear accelerations across a range of motion. By understanding the developmental processes building the peripheral vestibular system we can understand how those processes are disrupted in disease states that cause balance disorders and falls, and identity targets for therapeutic intervention.

PI_NAMEs: DEANS, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acceleration;Address;Afferent Neurons;Alleles;Anatomy;Apical;Articular Range of Motion;Auditory;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Body System;Cell Physiology;Cell surface;Cells;Cerebellum;Characteristics;Cleavage Under Targets and Release Using Nuclease;comparative;Crista ampullaris;Darkness;Data;design;Detection;Development;Developmental Process;Disease;emx2 protein;Epithelium;equilibration disorder;Equilibrium;Event;Exclusion;experimental study;falls;Family;Force of Gravity;Gene Deletion;Gene Expression;gene repression;Genes;Genetic;genetic approach;Genetic Transcription;Genomics;Goals;Growth;hair cell regeneration;Hair Cells;Individual;inner ear development;Inner Hair Cells;innovation;Kinocilium;Knock-out;Labyrinth;Lateral;Location;macula;Mechanics;Medial;Mediating;Molecular;Molecular Genetics;Morphology;Motion;mouse model;Movement;Mus;mutant;Organ;Pattern;Peripheral;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;planar cell polarity;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Posture;Process;promoter;Protein-Serine-Threonine Kinases;Proteins;Proteomics;receptor;Repression;Research;response;Saccule and Utricle;Saccule structure;Semicircular canal structure;Sensory;Sensory Hair;Sensory Receptors;Side;Signal Transduction;sound;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tissue repair;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Transitional Epithelium;Utricle structure;Vestibular function;Vestibular Hair Cells;Vestibular nucleus structure;vestibular system;Work

PROJECT_TITLE: Planar Polarity Mechanisms in Mammalian Inner Ear Development

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed experiments will dissect early molecular-cellular events in paligenosis, a recently described multi-stage repair mechanism in which differentiated cells are recruited back into the cell cycle for tissue regeneration in response to injury. The role of the kinase PERK in the early stages of paligenosis will also be tested, drawing a comprehensive, global map of the earliest kinase activity that triggers paligenosis. Given that precancerous lesions in multiple tissues occur initially due to paligenosis of mature cells and that kinases, including PERK, are targetable by several drugs, the experiments could lead quickly to new targets that block metaplasia in multiple settings.

PI_NAMEs: MILLS, JASON C (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: activating transcription factor 3;Activity Cycles;Acute;adult stem cell;Agonist;Apoptosis;Architecture;Autophagocytosis;Back;Bacterial Infections;biological adaptation to stress;Cell Cycle;cell dedifferentiation;Cell Differentiation process;Cells;Cellular Stress;Cessation of life;Chief Cell;Chronic;chronic infection;Collaborations;Data;Development;Dose;Double-Stranded RNA;Drug Targeting;EIF-2alpha;endoplasm;Enzymes;Event;Excision;experimental study;fetal;Funding;Future;Gene Activation;Generations;Genes;Helicobacter;Helicobacter Infections;Helicobacter pylori;human tissue;Hydroxychloroquine;Immunofluorescence Immunologic;Inflammation;inhibitor;Injury;Knowledge;Lead;Lesion;loss of function;LoxP-flanked allele;Lysosomes;Malignant Neoplasms;Manuscripts;Maps;Membrane;Messenger RNA;Metaplasia;Mitosis;Modeling;Molecular;mouse model;Mucous Membrane;multiple omics;Mus;Mutagenesis;Mutant Strains Mice;Mutation;Natural regeneration;new therapeutic target;paligenosis;Pathway interactions;PERK kinase;Pharmaceutical Preparations;Phenotype;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;premalignant;Prevention;Process;progenitor;programs;promoter;Proteins;Proteome;Publishing;recruit;Regulation;repaired;Research;Research Personnel;response;response to injury;Ribosomes;Risk;Role;Rough endoplasmic reticulum;Sample Size;Sampling;single-cell RNA sequencing;Sirolimus;spasmolytic polypeptide;stem cell proliferation;stem cells;Stomach;Stress;stress kinase;Tamoxifen;Testing;Tissue Microarray;tissue regeneration;Tissues;TP53 gene;Transcript;Translations;transmission process;tumor;tumor progression;tumorigenesis;Western Blotting;Wild Type Mouse;Wing;Work

PROJECT_TITLE: MECHANISMS OF CHIEF CELL DEDIFFERENTIATION

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Glaucoma is a blinding disease for which neuroprotective treatments are desperately needed to prevent the loss of retinal ganglion cells (RGCs) and their axons. This proposal will investigate the mechanisms by which the small protein, sigma-1 receptor (S1R), regulates protein secretion from optic nerve head astrocytes (ONHAs) to protect RGC axons in glaucoma. Results from this proposal will provide valuable information on how drugs such as S1R agonists can best be used to provide neuroprotection in glaucoma and will identify new therapeutic targets within the astrocyte secretome.

PI_NAMEs: BOLLINGER, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adult;Agonist;Astrocytes;Axon;Axonal Transport;Biotinylation;Blindness;Cell Communication;Cell Death;Cell secretion;Cell Separation;Cell Survival;Cells;Coculture Techniques;Cytoprotection;Disease;endoplasmic reticulum stress;experience;experimental study;Exposure to;extracellular;Eye;Generations;genetic approach;Glaucoma;Global Change;Goals;Grant;Harvest;Health;improved;In Vitro;in vivo;inflammatory milieu;Investigation;Knockout Mice;Laboratories;Ligands;Mediating;Metabolism;Microspheres;Mitochondria;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;Neurites;Neuroglia;Neurons;neuroprotection;new therapeutic target;novel;Ocular Hypertension;Optic Disk;Optic Nerve;optic nerve disorder;Oxidative Stress;Pathway interactions;Pentazocine;Pharmaceutical Preparations;Predisposition;prevent;protective effect;protective pathway;protein protein interaction;Protein Secretion;Proteins;Proteomics;Rattus;Receptor Activation;Receptor Inhibition;Regulation;Reporting;response;Retina;Retinal Ganglion Cells;Role;sigma-1 receptor;Silicone Oils;Stress;superior colliculus Corpora quadrigemina;System;Testing;therapeutic target;transcriptome;translational impact;translatome;Vision;Visual Cortex;Visual System

PROJECT_TITLE: The Mechanism of Sigma 1 Receptor Mediated Neuroprotection in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cystic Fibrosis;Genetics;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: NORFOLK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PHR: Project Narrative: Chronic inflammation in Cystic Fibrosis (CF) impairs mucociliary clearance and creates an aging environment that further damages the lung. This proposal will evaluate the efficacy of using an epigenetic modulator to target cellular senescence in the CF lung as a novel therapeutic strategy, which is independent of CFTR modulator therapy and suitable for an aging CF population.

PI_NAMEs: KRICK, STEFANIE ;SANDERS, YAN  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age acceleration;age related changes;age-related disease;Aging;aging mechanism;aging population;aging process;Air;Airway Disease;airway inflammation;anti aging;ATAC-seq;Binding;Binding Sites;Bromodomain;bronchial epithelium;Caring;Cell Aging;Cell Physiology;Cells;cellular targeting;Characteristics;Chemicals;Child;Childhood;Chromatin;Chronic;Chronic Disease;combat;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;demographics;Disease;drug development;efficacy evaluation;Elements;enhancer-binding protein AP-4;Enhancers;Environment;Epigenetic Process;epigenetic regulation;Epithelial Cells;experience;Family;Fibrosis;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;hallmarks of aging;Hematology;Histone Acetylation;Impairment;improved;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;Interleukin-1 alpha;Interleukin-6;Knock-out;Life Expectancy;Liquid substance;Lung Diseases;lung injury;lung preservation;Mediating;member;Methods;Modeling;Morbidity - disease rate;mortality;Mucociliary Clearance;Mus;Noise;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Patients;Persons;Phase I/II Clinical Trial;Population;Process;Production;programs;promoter;Proteins;Pulmonary Cystic Fibrosis;pulmonary function;Rattus;Reader;recruit;Regenerative capacity;Regulatory Element;Reporting;Role;senescence;senescence associated secretory phenotype;senescent cell;Solid Neoplasm;Testing;therapeutic target;Tissues;Transcription Coactivator;transcription factor;Transcription Factor AP-1;Transforming Growth Factor beta

PROJECT_TITLE: Epigenetic Modulation of Cellular Senescence in the Cystic Fibrosis Lung

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative Human Cytomegalovirus is a leading cause of birth defects. Those defects can dramatically impact the lives of the children (and their parents) that suffer from them. My research is aimed at understanding the underlying mechanisms involved in the development of those defects to ameliorate and, hopefully, prevent their occurrence.

PI_NAMEs: FORTUNATO, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 1q23;1q42;3-Dimensional;Auditory;Automobile Driving;Basement membrane;Binding;Birth;Brain Stem;CCCTC-binding factor;cell motility;Cell Physiology;cell type;Cells;Central Nervous System;Cerebrum;Charcot-Marie-Tooth Disease;Child;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;Coculture Techniques;Communities;confocal imaging;Congenital Abnormality;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Defect;design;Development;Disease;DNA;DNA Damage;Down-Regulation;drug development;drug discovery;early childhood;Engineering;Environment;Excision;experimental study;Extracellular Matrix;Eye;Genes;Genetic Transcription;Goals;Grant;Hair Cells;Hearing;Human;Immunofluorescence Immunologic;In Vitro;Infant;infant infection;Infection;Link;Literature;live cell imaging;Maps;Measures;Mechanics;Membrane Proteins;Messenger RNA;Microcephaly;Modeling;Motor Neurons;Mutation;Myelin;Myelin P0 Protein;Myelin Proteins;Myelin Sheath;myelination;Nerve;Neural Conduction;Neurites;neurodevelopment;Neuroglia;Neurons;Newborn Infant;nidogen-1;Organoids;Outcome;Parents;Pathogenesis;Pathway interactions;Patients;Peripheral Nervous System;prevent;Production;protein biomarkers;Proteins;Rattus;Reporting;Research;Sampling;Schwann Cells;Sensorineural Hearing Loss;Signal Transduction;Site;Stains;stem;Surgical incisions;Syndrome;System;three dimensional cell culture;Time;tissue culture;Tissue Sample;Transcript;Translating;Transmission Electron Microscopy;transmission process;Viral Proteins;Virus;Work

PROJECT_TITLE: HCMV infection downregulates nidogen 1 and myelin protein zero

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Fetal Alcohol Spectrum Disorders (FASD) describe a continuum of ethanol-induced structural defects causing severe impact both on child health and society in general. Craniofacial malformations are common in FASD, yet we know little of the ethanol-sensitive cellular and molecular mechanisms driving facial formation. Our proposal will conceptually and mechanistically advance our understanding of the ethanol-sensitive cell behaviors and molecular mechanisms contributing to structural malformations and will provide a conceptual framework to pursue predictive, diagnostic, and therapeutic approaches to FASD.

PI_NAMEs: LOVELY, CHARLES BENJAMIN (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Actins;Adhesions;Adult;alcohol exposure;Anterior;Attenuated;Automobile Driving;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Adhesion;cell behavior;cell motility;Cell Polarity;Cell Shape;Cells;Child Health;Complex;confocal imaging;Craniofacial Abnormalities;Defect;Development;Diagnostic;Dose;driving behavior;E-Cadherin;Embryo;Endoderm;Endoderm Cell;Ethanol;Etiology;Event;experimental study;Face;Fetal Alcohol Spectrum Disorder;Fetal Heart;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profile;Gene Proteins;Genes;Genetic;Genetic Epistasis;genetic risk factor;Human;in vivo;in vivo Model;insight;Jaw;Link;Liver;malformation;migration;Molecular;Morphogenesis;Mus;mutant;Mutation;Neural Crest;novel therapeutic intervention;Pathway interactions;Pharyngeal structure;Phosphorylation;planar cell polarity;Process;Proteins;receptor;receptor expression;response;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Smad Proteins;Societies;Structural Congenital Anomalies;Structural defect;Testing;Therapeutic;Tissues;Work;Zebrafish

PROJECT_TITLE: An ethanol-sensitive, Bmp-PCP dependent pathway regulating endoderm cell behaviors

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Acute kidney injury (AKI) is the most common renal disease requiring hospitalization and is becoming a widely recognized contributor toward the development of chronic kidney disease (CKD) and Th17 cells have been shown to play an important role in the contribution of AKI and CKD. The current study will seek to investigate the dynamic activation and functional differences in Th17 cells at different stages of AKI or CKD. We will also utilize strategies to block Th17 activity or associated co-factors such as GM-CSF to identify how Th17 cells affect specific kidney cell types during AKI and CKD.

PI_NAMEs: BASILE, DAVID P. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Adoptive Transfer;Affect;antagonist;Antigen-Presenting Cells;Attenuated;B-Lymphocytes;Biological;Blood Vessels;Calcium Channel;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;cell type;Cells;cellular targeting;channel blockers;Chronic Kidney Failure;cofactor;Complex;cytokine;Cytometry;Data;Dependence;Development;Disease Progression;Exposure to;FDA approved;Fibrosis;Gene Expression Profile;Gene Targeting;Genetic Transcription;Germ Cells;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Heterogeneity;high salt diet;Hospitalization;Human;Hypertension;IL17 gene;Immune;Impairment;Inflammatory;Injury;Injury to Kidney;Interleukin-1;Interleukin-6;interstitial;Kidney;kidney cell;Kidney Diseases;knockout gene;Long-Term Effects;Lymphocyte;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;Memory;Modeling;mouse model;Mus;Nature;nephrogenesis;neutrophil;novel;Pathogenicity;Pathway interactions;pharmacologic;Phase;Phenotype;Physiological;Play;pleiotropism;Population;Predisposing Factor;Predisposition;Rattus;receptor;Recovery;Regulation;Regulatory Pathway;Regulatory T-Lymphocyte;Renal function;repaired;Reporter;response;response to injury;restoration;Rodent Model;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Source;Spatial Distribution;T-Lymphocyte;Techniques;tertiary lymphoid organ;Testing;Therapeutic;Tissue imaging;tissue repair;Transforming Growth Factor beta

PROJECT_TITLE: Long-term effects of acute renal failure

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We propose investigations of two recently discovered Paneth Cell (PC) anti-microbial peptides (AMPs), Peptide YY (PYY) and Neuropeptide Y (NPY), that were previously known only to be gut hormones involved in the regulation of satiety. However, PC-NPY and PC-PYY represent a new class of PC-AMPs that have roles in maintaining gut microbial commensalism and providing immune defense against pathogens. New lines of inquiry are proposed to gain mechanistic and conceptual insights to their actions under conditions of health and disease.

PI_NAMEs: CHANG, EUGENE B (contact);PETERS, BRIAN M;PIERRE, JOSEPH F

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Affect;Amphibia;anorexigenic peptide;Anti-Bacterial Agents;anti-fungal agents;anti-microbial peptide;antimicrobial;Ascending colon;beta-Defensins;Biochemical;Bioinformatics;biophysical properties;Candida albicans;Cell Physiology;Collaborations;Crohn's disease;Data;Dipeptidyl-Peptidase IV;Disease;Distal part of ileum;Endocrine;experimental study;Functional disorder;fungus;Gene Expression;Genetic;Grant;gut dysbiosis;gut microbes;gut microbiota;Health;Hormones;host-microbe interactions;Immune;Immunologic Factors;In Vitro;in vivo;insight;Intestinal Hormones;Intestines;Investigation;Journals;L Cells;Lamina Propria;Liquid substance;magainin;Maintenance;Malassezia;Measures;Mediating;Mediator;member;Microbe;microbial;Microbiology;microbiota;Modification;Motion;Mucous body substance;multidisciplinary;Muramidase;mutant;neuropeptide Y;novel;Paneth Cells;pathobiont;pathogen;pathogenic bacteria;pathogenic fungus;patient subsets;Peptide YY;Peptides;Physiological;Physiology;Play;Population;Predisposition;Productivity;Property;protein expression;Regulation;Regulatory Pathway;Resources;response;Role;Satiation;Science;Secretory Vesicles;Serum;Signal Pathway;Structure;Sum;Surface;Symbiosis;Technology;Transgenic Mice;Virulent;working group;Yeasts

PROJECT_TITLE: Exploring the role, regulation, and antimicrobial function of Paneth cell peptides PYY and NPY in maintaining gut microbial commensalism and innate immune defense

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Adolescent and young adult cancer survivors (AYAs) are at risk for significant financial hardship. We are proposing to combine two evidence-based financial hardship interventions and test the influence of the resulting multilevel intervention, FinFit, on financial hardship among AYAs treated at NCI Community Oncology Research Program sites. Results will prepare us to scale up FinFit to diverse settings where vulnerable AYA cancer survivors are often served.

PI_NAMEs: BIRKEN, SARAH ABIGAIL;SALSMAN, JOHN  (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Address;Administrator;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adoption;Aftercare;Age;Appointment;Bankruptcy;cancer care;Cancer Center;cancer diagnosis;Cancer Patient;Cancer Survivor;Caring;Communities;community based practice;Community Clinical Oncology Program;community intervention;Community Networks;community setting;comparison control;Control Groups;cost;Cost Savings;Counseling;Data;design;Development;Diagnosis;digital;disorder risk;effectiveness/implementation trial;efficacy trial;Eligibility Determination;Employment;Evaluation;evidence base;experience;Financial Hardship;Financial Support;financial toxicity;follow-up;Future;future implementation;Geography;Goals;Health;Health Care Costs;Health Insurance;implementation facilitation;implementation science;implementation trial;improved;Individual;informant;Insurance Coverage;Interruption;Intervention;Interview;Life Expectancy;literacy;Malignant Neoplasms;Mediating;medication nonadherence;Methods;Modality;Morbidity - disease rate;mortality;National Cancer Institute;Newly Diagnosed;older adult;Oncology;Participant;patient level intervention;pilot trial;Populations at Risk;preference;prevent;primary outcome;Procedures;Productivity;programs;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;remote delivery;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;scale up;Science;Site;standard care;Structure;Survival Rate;Survivors;Testing;therapy design;Transportation;Underserved Population;United States;virtual delivery;vulnerable adolescent;Work

PROJECT_TITLE: Addressing financial hardship in adolescent and young adult cancer survivors: Efficacy and implementation of a multilevel intervention in community-based oncology practices

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Prevention;Sleep Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Insufficient sleep is a strong cardiovascular risk factor and its negative impact may be exacerbated in populations predisposed to cardiovascular disease, such as the offspring of hypertensive families. We will investigate whether experimental sleep restriction increases blood pressure and impairs cardiovascular function in individuals with a parental history of hypertension, and whether the hypothesized adverse impact of shortened sleep is greater in this group compared to individuals without a parental history of hypertension. This study will inform on the role of sleep deficiency in deteriorating the cardiovascular profile of those with a familial predisposition to hypertension, and guide future preventative strategies targeting sleep to reduce cardiovascular risk in vulnerable populations.

PI_NAMEs: COVASSIN, NAIMA  (contact)

PROGRAM_OFFICER_NAME: SCHUM, PAULA

PROJECT_TERMS: Accounting;Acute;Adult;Adverse effects;adverse outcome;Affect;Attenuated;Baroreflex;Behavioral;Blood Pressure;blood pressure elevation;Blood Vessels;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Communities;Community Health;comparison group;Data;Deterioration;Development;DNA Methylation;Electroencephalography;Endothelium;Enhancers;Ensure;Epidemiology;Epigenetic Process;Evaluation;Event;Exhibits;experience;Experimental Models;experimental study;Family;Family history of;functional genomics;Future;Genes;high risk population;Hour;Hypertension;hypertensive;Impairment;Individual;Infrastructure;Inpatients;insight;Laboratories;Life;Link;Measures;medical information system;Modeling;Modification;Monitor;neural;normotensive;novel;offspring;Outcome;Parents;Participant;Phase;Phenotype;Physiological;Population;population health;precision medicine;Predisposition;Prevalence;Prevention strategy;prognostic;Randomized;Recording of previous events;Recovery;Regulation;Research;Research Design;Research Personnel;response;Risk;Risk Factors;risk stratification;Role;Sampling;Sleep;Sleep Deprivation;stressor;System;transcriptomics;translational framework;Visit;Vulnerable Populations;wearable device;Work;young adult

PROJECT_TITLE: Effects of Experimental Sleep Restriction in Offspring of Hypertensive Parents

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICS

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The method to be developed in this project will permit termination and prevention of heart rhythm disorders including atrial fibrillation, ventricular tachycardia, and ventricular fibrillation by conversion to a normal rhythm using low-voltage electric fields. Compared to the high-voltage fields currently in use, this new method will cause less damage to heart tissue, prolong the battery life of the device used to deliver the fields, and cause less pain to the patient. In addition to providing a safer and gentler alternative for patients than traditional electrical cardioversion or defibrillation, the proposed method has the potential to provide new treatment avenues for subsets of patients with atrial and ventricular arrhythmias for whom current therapies are ineffective or produce intolerable side effects, and could benefit millions of Americans.

PI_NAMEs: FENTON, FLAVIO H (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Acceleration;Adverse effects;American;Anatomy;Animals;Anxiety;Anxiety Disorders;Arrhythmia;Atrial Fibrillation;battery life;Calcium;Calcium Signaling;Cardiac;Cardiovascular Diseases;Cause of Death;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinical translation;Complement;Complex;Computer Models;Computer Simulation;computerized tools;Data;Development;Devices;Disease;effective therapy;Elderly;Electric Countershock;electric field;Electrophysiology (science);experimental study;Family suidae;Frequencies;Future;Goals;Health;Heart;Heart Atrium;heart dimension/size;Heart failure;heart rhythm;high end computer;Human;human model;implantable device;improved;in silico;in vivo;ineffective therapies;Ischemic Stroke;Knowledge;Life;Machine Learning;machine learning algorithm;Maps;mathematical model;Methodology;Methods;Modeling;mortality;multi-scale modeling;myocardial damage;Nature;novel;Optics;Pain;Pain Disorder;patient subsets;Patients;Physiologic pulse;Population;Prevalence;Prevention;Protocols documentation;Psychological reinforcement;Quality of life;Radiofrequency Interstitial Ablation;research clinical testing;Resolution;Rotation;Shock;side effect;simulation;spatiotemporal;Structure;success;sudden cardiac death;Testing;Time;Tissues;tool;translational applications;United States;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia;Visualization;voltage

PROJECT_TITLE: Integrative High-Resolution Experimental and Multiscale Modeling of Arrhythmias to Optimize Low Energy Anti-fibrillation Pacing (LEAP)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Individuals with lower-limb amputations are at higher risk of falling and sustaining injuries compared to able- bodied individuals in part due to the limited ability of their prosthetic devices to adapt to different ambulatory activities. The goal of this project is to determine if a prosthesis that automatically adjusts its stiffness according to the ambulatory activity can improve the balance control of individuals with lower limb amputations. By matching the prosthesis stiffness to the task requirements, we will significantly improve balance control and decrease fall risk for those with lower-limb amputations.

PI_NAMEs: NEPTUNE, RICHARD R (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Algorithms;Amputation;Ankle;ankle prosthesis;biomechanical test;Categories;Clinical;comparison control;Computer software;Data;Detection;Device Designs;Devices;Environment;Equilibrium;experimental study;fall injury;fall risk;foot;Gait;Goals;Health;high risk;human subject;improved;Incidence;Individual;Injury;insight;Knee;Life;light weight;limb amputation;Limb Prosthesis;Lower Extremity;Machine Learning;machine learning algorithm;Mechanics;Muscular Atrophy;novel;open source;Outcome;Outcome Measure;Outcomes Research;Patient Self-Report;Persons;Phase;Population;powered prosthesis;Prosthesis;prosthesis wearer;prosthetic foot;Qualifying;Quality of life;Ramp;Research;residual limb;Robotics;sensor;service member;Signal Transduction;Speed;Surface;Surveys;System;Techniques;Testing;Training;Veterans;Walking;Work

PROJECT_TITLE: Automatic mode-dependent and phase-varying prosthetic foot  stiffness modulation to improve balance control in individuals with lower-limb amputations

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chronic myeloid leukemia (CML) is malignant blood disease that currently requires lifelong treatment with medications that are expensive and have substantial and even life-threatening side effects. When CML patients with undetectable disease stop their medication, the leukemia recurs in most but not all cases suggesting that the body has defenses that can control low levels of leukemia, but the mechanisms involved are not understood. This application will utilize a new mouse CML model of so-called “treatment-free remission” to determine these biological mechanisms, which should lead to new approaches to increase the proportion of patients who can attempt to stop their medication and successfully stay in remission.

PI_NAMEs: VAN ETTEN, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: ABL1 gene;Address;Age;American;Apoptosis;Biological;Biopsy Specimen;Blood Vessels;Bone Marrow;Bone marrow biopsy;Bone Marrow Cells;CD8-Positive T-Lymphocytes;Cell Proliferation;Cells;Chimera organism;Chronic Myeloid Leukemia;Clinical;conditional knockout;conditioning;congenic;cost;Cytogenetics;cytokine;Cytometry;Data;Death Rate;Diagnosis;Dichloromethylene Diphosphonate;Disease;Disease remission;disorder control;DNA Damage;Drug Costs;Economics;Elements;Eligibility Determination;Environment;Exhibits;experience;experimental study;EZH2 gene;Frequencies;Functional disorder;gene cloning;Genes;Gleevec;Goals;granulocyte;Health;Hematological Disease;Hematopoietic stem cells;Human;Imatinib mesylate;Immune;Immune system;immunodeficiency;inhibitor;inhibitor therapy;Knowledge;leukemia;Leukemic Cell;leukemic stem cell;Life;Life Expectancy;Liposomes;loss of function mutation;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mesenchymal;Modeling;Molecular;monocyte;mouse model;Mouse Strains;Mus;Mutation;Myeloproliferative disease;Natural Killer Cells;novel;novel strategies;novel therapeutic intervention;Oncogenes;Outcome;p19ARF;Pathway interactions;Patients;payment;PDL1 inhibitors;peripheral blood;Phagocytes;Pharmaceutical Preparations;Philadelphia Chromosome;physiologic model;Population;Prevalence;Process;Proteins;Proto-Oncogene Proteins c-abl;Quantitative Reverse Transcriptase PCR;Radiation;Recurrence;Recurrent disease;Regulatory T-Lymphocyte;Relapse;replication stress;Research;response;Role;Sampling;senescence;side effect;Stress;Stromal Cell-Derived Factor 1;success;Testing;therapeutic evaluation;Time;Transcript;Transgenic Mice;Transgenic Organisms;Translating;Transplant Recipients;Transplantation;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Mechanisms of treatment-free remission in a mouse model of chronic myeloid leukemia

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Aging;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Immune dysregulation appears central to liver transplant recipient immune dysfunction, frailty, and early death. We have identified the Liver Immune Frailty Index (LIFI), based on pre-transplant laboratory biomarkers of immune function, which accurately stratifies patients into low-, moderate-, and high-risk of early death post- transplant. This project aims to perform robust, multicenter validation of LIFI and longitudinal assessment of pre-transplant immune dysfunction to develop a more granular understanding of this process and to facilitate identification of targets for early intervention and improved transplant outcomes.

PI_NAMEs: LUNSFORD, KERI ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: adaptive immunity;Anti-Inflammatory Agents;Antigens;Award;biobank;Biological;Biological Markers;biomarker panel;Biometry;Body Composition;Cause of Death;Cells;Cessation of life;chemokine;chronic liver injury;Cirrhosis;Clinical;Clinical Assessment Tool;Clinical assessments;Clinical Data;Clinical Protocols;clinical risk;cohort;Collection;Complement;cytokine;Data;Development;Dimensions;Early Intervention;Ethics;Evaluation;Evolution;exhaustion;Exhibits;Flow Cytometry;Fractalkine;frailty;Futility;Hepatitis C virus;high risk;Immune;immune function;Immune system;Immune System Diseases;Immune Tolerance;immunodeficiency;Immunoglobulin G;Immunologic Markers;Immunologic Stimulation;Impairment;improved;improved outcome;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;intrahepatic;Laboratories;Leukocytes;Link;Liquid substance;Liver;liver transplantation;Machine Learning;Malnutrition;Measurement;Measures;Medical;Metabolic stress;metabolomics;MMP3 gene;Modeling;mortality;mortality risk;multiple omics;Muscular Atrophy;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Organ;Outcome;Outcome Study;Oxidative Phosphorylation;patient stratification;Patients;Performance;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Plasma;Population;post-transplant;predictive modeling;Prevalence;prevent;Process;Protein-Energy Malnutrition;Proteomics;Publishing;Qualifying;radiological imaging;recurrent infection;Risk;Risk Assessment;risk prediction;risk stratification;Sampling;sarcopenia;Scientist;senescence;Sentinel;Serum;Severities;statistics;Testing;therapeutic target;Time;tool;transcriptome sequencing;transcriptomics;Transplant Recipients;Transplant Surgeon;Transplantation;Validation;Waiting Lists;wasting

PROJECT_TITLE: Multi-Center Validation and Biologic Assessment of a Novel Pre-Transplant Biomarker Panel to Predict Liver Transplant Recipient Mortality

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The development of effective vaccines for number of viral diseases that target the female reproductive tract (FRT) has been challenging. Antiviral CD8 T cells located in FRT have proven protective roles against these viruses. This proposal seeks to understand the rules that control positioning and function of these CD8 T cells such that they can be induced via future vaccines to generate protective immunity.

PI_NAMEs: BEURA, LALIT K (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acceleration;Adoption;Antibodies;Antigens;Automobile Driving;Biogenesis;Biological Assay;Biology;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;cervicovaginal;Coculture Techniques;Controlled Environment;cytokine;Defense Mechanisms;density;Development;dysbiosis;Effector Cell;Environment;Epithelium;Exposure to;female reproductive tract;Future;Generations;Genetic;Genetic Transcription;Germ-Free;Goals;Heterogeneity;Human;Immune;Immunity;Immunologic Surveillance;improved;In Vitro;in vivo;Infection;Inflammation;inflammatory milieu;insight;Integrin alphaV;Integrins;Interferons;Invaded;Knowledge;Laboratory Animals;Maintenance;Mediating;Memory;Methods;microbial;microbiome;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Nature;neutralizing antibody;nonhuman primate;novel;novel strategies;Organ;Organoids;Parabiosis;pathogen;pathogenic virus;Pathogenicity;Pathway interactions;Peptide Hydrolases;Phenotype;Population;Positioning Attribute;Process;Production;Property;recruit;Regulation;Reporter;reproductive;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Source;Supporting Cell;System;T cell differentiation;T-bet protein;T-Lymphocyte;targeted treatment;Testing;Tissues;trait;transcription factor;Transforming Growth Factor beta;Up-Regulation;Vaccination;Vaccines;Vagina;Viral;Virus;Virus Diseases;Women's study;Work

PROJECT_TITLE: T lymphocyte-mediated protection of the reproductive mucosa

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative Circadian rhythms control physiology and behavior; disruptions in these regulatory mechanisms predispose individuals to various metabolic diseases, such as atherosclerosis. Hence, understanding the circadian mechanisms that control lipid metabolism at cellular and molecular levels might be useful in developing new methods to prevent and/or treat these diseases. The studies proposed herein should explain how macrophage specific Bmal1 controls circadian regulation of modified lipoprotein uptake, cholesterol efflux and intracellular trafficking of cholesterol.

PI_NAMEs: PAN, XIAOYUE  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Ablation;Address;Apolipoprotein E;Area;ARNTL gene;Arterial Fatty Streak;Atherosclerosis;atherosclerosis risk;ATP binding cassette transporter 1;Behavior;Behavioral;Binding;Biochemical;Biology;Cholesterol;cholesterol control;Cholesterol Homeostasis;cholesterol trafficking;cholesterol transporters;Chronobiology;circadian;circadian biology;circadian pacemaker;circadian regulation;Circadian Rhythms;Development;Disease;Genes;Hour;Human;Impairment;Individual;Infiltration;Knowledge;Lesion;lipid metabolism;Lipoproteins;Literature;Liver;Lysosomes;Macrophage;member;Metabolic Diseases;Metabolism;Methods;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;Myocardial Infarction;new therapeutic target;novel;Nuclear Pore Complex;Nuclear Receptors;Pathway interactions;Physiological;Physiology;Plasma;Play;prevent;Process;Production;promoter;Proteins;Publishing;Regulation;Reporting;Repression;Role;Stroke;sudden cardiac death;Testing;Tissues;transcription factor;uptake;Zinc Fingers

PROJECT_TITLE: Bmal1, a master regulator of Macrophage cholesterol metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: Tuberculosis (TB) remains an onerous global public health burden. A significant number of household contacts, despite prolonged exposure to an Index case with active TB, do not generate IFN producing T cells and remain negative in the Interferon gamma Release Assay (IGRA), and therefore, in this application we will study IFN -independent T and B cell mechanisms regulating macrophage immunity. The knowledge gained from the proposed studies will allow identification of host protective mechanisms that can be used to design host directed therapies and in vaccine development.

PI_NAMEs: CHAN, JOHN R.;RIBEIRO-RODRIGUES, RODRIGO ;SALGAME, PADMINI  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immune response;Anti-Bacterial Agents;Antibodies;Antibody Affinity;Antibody Response;Antitubercular Agents;Area;Avidity;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Bacillus;Binding;Biological Assay;biomarker discovery;Brazil;CD4 Positive T Lymphocytes;Cloning;Collaborations;comparative;Computational Biology;cytokine;Data;design;Development;Diamond;Disease;Disease Outcome;Epidemiology;Exhibits;experience;Exposure to;Funding;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Helper-Inducer T-Lymphocyte;Household;Human;human disease;Humoral Immunities;Immune response;Immune system;Immunity;Immunocompetent;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Switch Recombination;Immunologics;Immunology;indexing;Individual;Infection;Infection Control;Interferon Type II;Interferons;Interleukin-1 beta;Knowledge;Link;Lymphoid;Macrophage;Maintenance;Mediating;Modeling;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nature;novel vaccines;Outcome;Pathogenesis;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;prevent;Probability;Procedures;Production;Public Health;Pulmonary Tuberculosis;recruit;Research Personnel;Resistance;response;Response Latencies;Risk;Role;Serology;Shapes;Signal Transduction;success;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Time;Tuberculosis;tuberculosis immunity;United States National Institutes of Health;vaccine development;Work

PROJECT_TITLE: Mechanisms of IFNg-independent T cell and B cell-mediated protection in TB.

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The metabolic heterogeneity of tumors is poorly understood, and more information is needed to uncover the metabolic features of tumors related to aggressiveness, tissue type, and patient demographics. This proposal aims to conduct a large-scale, pan-cancer metabolomics analysis to generate a publicly available resource, called the Human Cancer Metabolome Atlas, to provide a platform for all cancer researchers to study the landscape of tumor metabolism. Cancer metabolism has gained tremendous traction as a source of potential therapeutic targets, and this resource will not only help to better identify those targets, but it will also identify subpopulations of individuals who would best respond to these approaches.

PI_NAMEs: RUSHING, BLAKE RICHEY (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Area;Atlases;Biological Sciences;Cancer Biology;cancer cell;cancer therapy;cancer type;Characteristics;Clinical;clinically relevant;Collection;Communities;Crowns;Data;Data Analyses;Data Discovery;data harmonization;data mining;data repository;Databases;demographics;Development;Diagnostic;Dietary Intervention;Disease;Disease Outcome;exome sequencing;Foundations;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic variant;Genomics;Glucose;Glutamine;Growth;Heterogeneity;Human;Human Resources;Individual;Laboratories;Libraries;Link;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;Metadata;Methotrexate;Modeling;Molecular;Multivariate Analysis;neoplasm resource;Nonmetastatic;novel;novel therapeutic intervention;Nutritional;Outcome;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;personalized approach;personalized cancer therapy;personalized medicine;pharmacologic;Phenotype;precision nutrition;Process;protein expression;Proteins;Proteome;Proteomics;public database;Reference Standards;Reporting;repository;Research;Research Personnel;Resistance;Resolution;Resources;Role;Sampling;Solid Neoplasm;Source;Strategic Planning;survival outcome;System;targeted cancer therapy;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;tool;Traction;transcriptome sequencing;transcriptomics;trend;tumor;tumor heterogeneity;tumor metabolism;Tumor Promotion;United States National Institutes of Health

PROJECT_TITLE: Creation of the Human Cancer Metabolome Atlas

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE (RELEVANCE) Precise regulation of G protein-coupled receptor (GPCR) signaling is essential for proper function of the nervous system. KCTD proteins are a family of critical regulators of GPCR signaling in the brain, and they have been implicated in a variety of neuropsychiatric diseases including mood disorders. A detailed understanding of KCTD protein function is important both for understanding fundamental human biology and for its relevance to human disease.

PI_NAMEs: KRUSE, ANDREW ;LEVITZ, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;Acute;Agonist;Architecture;Area;beta-arrestin;Binding;Biochemical;Biological;Biological Assay;Biology;biophysical analysis;Biophysical Process;biophysical techniques;Biophysics;Brain;BTB/POZ Domain;C-terminal;Cell Line;Cells;Communication;Complex;Coupling;Cryoelectron Microscopy;Data;desensitization;Disease;Electrophysiology (science);extracellular;Family;Fluorescence Microscopy;Foundations;Functional disorder;G protein-coupled inwardly-rectifying potassium channel;G Protein-Coupled Receptor Signaling;G-protein Beta gamma;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;genetic regulatory protein;GTP-Binding Proteins;Health;Human;Human Biology;human disease;Human Genetics;In Vitro;Investigation;Ion Channel;Kinetics;Label;Length;Luciferases;macromolecular assembly;Mass Spectrum Analysis;Measures;Mediating;member;Mental disorders;Modeling;Molecular;Molecular Conformation;Molecular Neurobiology;Mood Disorders;Muscarinic Acetylcholine Receptor;N-terminal;Nervous System Physiology;Neurobiology;neuronal excitability;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;Neurotransmitter Receptor;Neurotransmitters;novel;Peptides;Potassium Channel;presynaptic;Protein Engineering;protein function;Proteins;Proteomics;receptor;Receptor Activation;receptor binding;receptor function;Receptor Signaling;Regulation;Reporter;Reproducibility;response;RGS Proteins;Role;Shapes;Signal Transduction;Structure;Synapses;Synaptic Transmission;technology development;Testing;Time;trafficking;Ubiquitin;Work

PROJECT_TITLE: Mechanisms of Regulation of Neuronal GPCRs by KCTDs

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Foodborne Illness;Genetics;Human Genome;Microbiome;Prevention

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Relevance Arsenicosis, is a worldwide threat to public health that leads to a variety of human diseases, including cancer. Our group showed the human microbiome plays a significant role in arsenic detox following ingestion. The proposed project continues this research uses germ-free and gnotobiotic mouse models with genetically engineered bacteria to study reduction, methylation, and thiolation reactions in the gut; evaluates how clinically prescribed antibiotics influences disease risk; and interrogates a novel mouse model of interindividual arsenicosis outcomes.

PI_NAMEs: MCDERMOTT, TIMOTHY ;WALK, SETH T (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acute;Address;Antibiotics;Arsenic;Arsenic Poisoning;Arsenicals;Bacteria;Bacterial Genome;bioaccumulation;Biochemical;C57BL/6 Mouse;cancer prevention;cancer risk;Carcinogens;Cephalosporins;Chronic;Clinical;Clinical Pharmacists;Clinical Pharmacology;Code;Collaborations;Country;Diabetes Mellitus;Disease;disease registry;disorder risk;drinking water;Drug Metabolic Detoxication;Ecology;Engineering;Ensure;Enzymes;Epidemiology;Evaluation;Excretory function;experimental study;Exposure to;Feces;Generations;Genes;Genetic Engineering;Genetic Polymorphism;Genome engineering;Germ-Free;Glycopeptide Antibiotics;Gnotobiotic;gut microbiome;Homeostasis;Human;human disease;Human Microbiome;Immune response;Immunology;in vivo;Individual;Individual Differences;Inductively Coupled Plasma Mass Spectrometry;Infection;Ingestion;insight;inter-individual variation;Interdisciplinary Study;Knowledge;Link;Liver;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;member;Metabolic Biotransformation;Metabolism;Methods;Methylation;microbial;microbiome;model organism;Modeling;Molecular;Molecular Biology;mouse model;Mus;novel;Opportunistic Infections;Outcome;Oxidation-Reduction;Pathway interactions;Penetrance;Persons;Play;Poison;Prevention Guidelines;Production;Productivity;programs;protective effect;Public Health;Reaction;Research;Risk;Risk Assessment;Role;Sepsis;Series;Skin Cancer;success;Technical Expertise;Testing;Time;Tissues;Toxic effect;Training;Vancomycin;Vascular Diseases;Walking;Whole Organism;Work

PROJECT_TITLE: Mechanisms of arsenic detoxification by the human microbiome

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Machine Learning and Artificial Intelligence;Muscular Dystrophy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Recent therapeutic approaches for individuals with neuromuscular disorders (NMD) have resulted in disease modifying therapies but benefits reported by patients, experienced in real-world settings, often elude the standard in-clinic examination. Emerging wearable devices allow for ubiquitous monitoring of physical mobility, but their widespread use in clinical applications is currently hampered by their moderate granularity and accuracy. This research aims to implement novel foot-worn devices that can accurately measure stride-by-stride spatiotemporal and kinetic gait parameters, which can be used as sensitive digital mobility outcomes (DMO) to reflect real-world ambulatory function in individuals with childhood onset NMD.

PI_NAMEs: MONTES, JACQUELINE  (contact);ZANOTTO, DAMIANO

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Accelerometer;Adolescence;Adult;Affect;Biological Markers;biomarker development;Child;Childhood;Clinic;Clinical;clinical application;Clinical assessments;clinical efficacy;clinical outcome measures;clinical research site;Clinical Trials;clinically relevant;cohort;Consensus;Development;Devices;Diagnosis;digital;Digital biomarker;Disease;Disease Progression;Duchenne muscular dystrophy;Early treatment;Enrollment;Environment;experience;Family;foot;functional outcomes;Future;Gait;gait examination;genetic testing;Guidelines;Heterogeneity;Hour;Impairment;Individual;infancy;instrument;Intervention;Kinetics;Length;Life;Machine Learning;machine learning model;Maps;Measures;Methods;Modeling;Monitor;monitoring device;Motor;motor neuron degeneration;Muscle;Muscle function;Muscular Atrophy;Neurologic;neuromuscular;Neuromuscular Diseases;neuromuscular system;novel;novel therapeutics;Outcome;Pathologic Processes;Patients;Persons;Pharmacotherapy;Phenotype;Predisposition;pressure;Prevalence;rare condition;remote monitoring;Reporting;Research;response;Sample Size;sensor;Severities;Severity of illness;Signal Transduction;spatiotemporal;Spinal Muscular Atrophy;supervised learning;Surrogate Endpoint;Symptoms;System;Testing;Therapeutic;Time;Walking;wearable device;Wrist

PROJECT_TITLE: Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Before doctors can use a single patient’s blood and tissue to make a diagnosis and begin medical care, the blood and tissue of many people must be examined and tested in research studies. This helps scientists and doctors understand disease, create accurate tests for diagnosis, and design new ways of treating illness, especially cancer. The Cooperative Human Tissue Network’s Southern Division at Duke University will continue to provide high-quality human blood and tissue samples to medical researchers.

PI_NAMEs: MCCALL, SHANNON JONES (contact)

PROGRAM_OFFICER_NAME: CHUAQUI, RODRIGO F

PROJECT_TERMS: 2019-nCoV;Accreditation;Addendum;Address;American;androgen independent prostate cancer;anti-cancer research;Assessment tool;Audience Research;Autopsy;biobank;Biological;Biological Assay;Biological Preservation;Biomedical Research;Biopsy;Blood;Blood specimen;Breast;calcification;Cancer Model;Caring;Clinical Data;Collection;college;Colon Carcinoma;Communication;Communities;community engagement;Community Health Education;Community Outreach;computerized data processing;Consent;Consultations;Continuing Education;Cooperative Human Tissue Network;Data;data mining;Dedications;Dermatopathology;design;Diagnosis;digital;digital imaging;Disease;E-learning;electronic consent;Ensure;Event;Faculty;Feedback;FGFR2 gene;Fostering;Genotype;Goals;Health;Health system;Hematopathology;Hospitals;Human;Image Analysis;Immunohistochemistry;improved;In Situ Hybridization;innovation;Institution;International;Intrahepatic Cholangiocarcinoma;Knowledge;Leadership;Liquid substance;Malignant Neoplasms;Medical;meetings;Metastatic Neoplasm to the Bone;Methods;Mission;molecular imaging;National Cancer Institute;Neoadjuvant Therapy;Neoplasm Metastasis;New Jersey;new technology;news;Newsletter;Nucleic Acids;operation;Outcome;Pathologist;Pathology;Patients;Persons;Phenotype;phenotypic biomarker;podcast;Population;posters;preservation;programs;public health relevance;Publications;Recommendation;repository;Research;Research Personnel;research study;Role;sample collection;Sampling;Scientist;Services;single-cell RNA sequencing;social media;Societies;soft tissue;Specimen;success;support network;Technology;Testing;Therapeutic;Tissue Microarray;Tissue Procurements;Tissue Sample;Tissues;Training;translational cancer research;Translational Research;trend;Trust;tumor;Underrepresented Populations;Universities;University Hospitals;web site;whole slide imaging;Writing

PROJECT_TITLE: Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE There is strong correlational and epidemiological data to support a link between exposure to high levels of manganese, dopamine dysregulation, and development of Attention Deficit and Hyperactivity Disorder (ADHD) and other neurodevelopmental disorders. Current research and treatments are limited by lack of reproducibility in animal and cellular studies limiting translational relevance to humans. Rigorous testing of effects of chronic sub-toxic exposures across sexes, genetic background, and disease-associated genotypes in animal and human-derived cell models will clarify the role of biological variability in the response to environmental exposures and individual differences in response to pharmacological interventions.

PI_NAMEs: BOWMAN, AARON B;HARRISON, FIONA EDITH (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adolescent;Adult;Affect;Age;Air;Animals;anxiety-like behavior;Attention deficit hyperactivity disorder;Automobile Driving;Autopsy;Behavior;behavior test;Behavioral;behavioral outcome;behavioral phenotyping;behavioral study;Behavioral Symptoms;Biochemical;Biological;Birth;Brain;brain tissue;Carrier Proteins;Cell Death;Cell Line;Cell model;Cells;Chemicals;Child;Childhood;Chronic;Clinical;common treatment;comparative;contaminated water;Data;Development;Diagnosis;Diet;Disease;DNA Sequence Alteration;Dopamine;dopamine transporter;Dopaminergic Cell;dopaminergic neuron;Dose;Drug usage;Electrophysiology (science);Environmental Exposure;Environmental Impact;Environmental Pollutants;Environmental Risk Factor;epidemiologic data;Epidemiology;Ethnic Origin;Etiology;Exhibits;experience;exposed human population;exposure route;Exposure to;Female;Frequencies;Future;gene environment interaction;General Population;Genes;Genetic;genetic approach;Genetic Models;Genetic Variation;genome wide association study;genomic locus;Genotype;Grant;Human;Human Characteristics;human induced pluripotent stem cells;Hyperactivity;Impairment;Impulsive Behavior;In Vitro;in vivo;Inbred BALB C Mice;Individual Differences;Inductively Coupled Plasma Mass Spectrometry;Intellectual functioning disability;Intervention;Investigation;Kinetics;Knowledge;Link;male;Manganese;Mental disorders;Metabolism;Metal exposure;Minerals;model development;Modeling;Motor Activity;Mus;neurochemistry;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuropathology;neuropsychiatric disorder;Neuropsychology;neuroregulation;Neurotransmitters;Oral;Outcome;Pathway Analysis;Pathway interactions;Periodicity;pharmacologic;Pharmacological Treatment;Phenotype;Pollution;Population;Post-Translational Protein Processing;Predisposition;Prevention strategy;Preventive treatment;Regulation;repetitive behavior;Reproducibility;Research;response;reuptake;Risk;Risk Factors;RNA;Rodent;Rodent Model;Role;Scanning;sex;sex variable;Signal Pathway;Slice;Soil;System;Testing;toxicant;Toxicant exposure;trait;translational potential;Variant;Water;Weaning

PROJECT_TITLE: Manganese exposure  and genetic diversity in risk mechanisms for neurodevelopmental disorders


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative This project is dedicated to create and disseminate novel computational tools that will enable accurate and robust segmentation, parcellation, and measurements of infant structural, functional and diffusion brain MRIs from multiple imaging centers, and to further identify imaging-based biomarkers for early diagnosis of at-risk infants. In particular, we will develop novel methods for tissue segmentation of cerebrum, subcortical structures and cerebellum, parcellation, multimodal measurements and early diagnosis, for large scale multi-center datasets. Finally, we will release our developed tools, along with all our processed data, to NDAR.

PI_NAMEs: WANG, LI  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Achievement;Address;Atlases;Attention;autism biomarker;Autism Diagnosis;autism spectrum disorder;Awareness;Behavior;behavior observation;Biological Markers;biomarker identification;Birth;Brain;Brain imaging;brain tissue;Cerebellar Cortex;Cerebellum;Cerebral cortex;Cerebrum;ChatGPT;Child;Childhood;Clinical;computerized tools;connectome;contrast enhanced;convolutional neural network;Data;Data Set;Databases;Dedications;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;diverse data;early detection biomarkers;Early Diagnosis;Early Intervention;effective intervention;Effectiveness;Ensure;Exhibits;experience;Free Will;Functional Magnetic Resonance Imaging;Goals;Grain;graph neural network;Growth;heterogenous data;Hybrids;Image;Image Enhancement;imaging biomarker;imaging facilities;imaging study;improved;Infant;infant monitoring;innovation;insight;Intervention;Joints;learning network;Life;Magnetic Resonance Imaging;Maps;Measurement;Methods;Modeling;multidisciplinary;multimodal neuroimaging;multimodality;myelination;neuroimaging;novel;Outcome;Pattern;Process;Protocols documentation;Research;Resolution;Risk;Scanning;Semantics;social communication;Social Interaction;Source;Structure;Surface;Testing;Tissues;tool;Training;training data;ultra high resolution;Variant;Vendor;Visit

PROJECT_TITLE: Computational Neuroimaging MRI for Studying Early Brain Development with Autism

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Autoimmune Disease;Endocrine Disruptors;Psoriasis

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF MEMPHIS

PHR: The skin is the largest organ of the body and is essential for life. The role of the aryl hydrocarbon receptor in epidermal barrier function and homeostasis is an emerging topic. This project will increase our understanding of the function of the AHR in skin biology, and help to explain how some chemical ligands that activate this receptor contribute to disease, while other ligands have beneficial therapeutic effects.

PI_NAMEs: SUTTER, THOMAS R (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Affect;Agonist;antagonist;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Automobile Driving;Biological;Biology;Cataloging;Chemicals;Chronic small plaque psoriasis;Cytokine Activation;cytotoxic;Development;Dioxins;Disease;Dose;Environmental Pollutants;Epidermis;Epithelium;Equilibrium;Genetic;Goals;Health Promotion;Homeostasis;Human;Imiquimod;in vivo;Inflammation;Inflammatory;inflammatory modulation;inhibitor;irradiation;keratinocyte;keratinocyte differentiation;knock-down;Lesion;Life;Ligands;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Lipids;Mediating;Metabolic;Metabolic Control;Metabolic Pathway;metabolome;metabolomics;Microbe;Modality;Modeling;Molecular;mouse model;multiple omics;Mus;Organ;pathogen;Pathway interactions;Permeability;Pharmacologic Actions;Phase;Physiological Processes;pre-clinical;Process;programs;Psoriasis;receptor;Receptor Activation;Receptor Signaling;Regulation;repaired;Reporting;response;Role;Signal Pathway;Signal Transduction;Skin;skin barrier;skin disorder;System;Testing;Tetrachlorodibenzodioxin;Therapeutic;Therapeutic Effect;Toxic Actions;Toxic effect;Toxicology;Water;Work

PROJECT_TITLE: Cellular Determinants of AH Receptor Signaling


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project narrative. DNA polymerase theta (Polq), a DNA repair factor important for microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs), has recently been validated as a drug target in BRCA1/2 mutated cancers in pre-clinical studies. Early stage Polq inhibitors (Polqi), however, have significant deficiencies which may limit their efficacy and development in clinical studies. Our collaborative team (Pomerantz, Johnson, and Childers labs) plans to develop a novel chemical entity as a potentially best-in-class Polqi by employing an innovative prodrug strategy which is expected to prolong its exposure and activity in vivo.

PI_NAMEs: CHILDERS, WAYNE E;POMERANTZ, RICHARD T (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: analog;Animals;Binding Proteins;Biochemical;Biological Assay;Biological Availability;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;Breast;cancer cell;candidate identification;Cells;Characteristics;Chemicals;Clinical Research;Collaborations;Combined Modality Therapy;Data;design;Deuterium;Development;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA-Directed DNA Polymerase;Dose;Double Strand Break Repair;Drug Kinetics;Drug resistance;Drug Targeting;druggable target;efficacy study;Exhibits;Female;Generations;Goals;Half-Life;HCT116 Cells;homologous recombination;homologous recombination deficiency;improved;In Vitro;in vivo;inhibitor;Injections;innovation;Kinetics;Knockout Mice;Liver Microsomes;Malignant neoplasm of ovary;Malignant Neoplasms;Measurement;Measures;Mediating;Modeling;mouse model;Mus;mutant;Mutate;novel;Oral;Oral Administration;Ovarian;Pancreatic carcinoma;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Chemistry;Phenotype;Physical Chemistry;Plasma;Plasma Proteins;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;precision medicine;preclinical study;Predisposition;prevent;Prodrugs;Prostate;Publishing;Reporter;Reporting;Resistance;Solid Neoplasm;synergism;Toxic effect;tumor growth;Tumor Volume;Weight;Xenograft procedure

PROJECT_TITLE: Development of Best-in-Class Pol-Theta Inhibitors

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Nutrition;Obesity;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Maintaining glucose control (i.e. HbA1c <7.0%) reduces the risk of microvascular complications in T2DM patients; currently approximately one half of patients with T2DM fail to maintain the target for glucose control. Thus, therapeutic regimens that produce a durable reduction in the HbA1c is an unmet need for the management of patients with T2DM. The current grant proposal is a comparative effectiveness study of the efficacy and durability of HbA1c reduction by two initial combination therapies in patients with new onset diabetes.

PI_NAMEs: ABDUL-GHANI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Adipocytes;Agonist;Algorithms;Applications Grants;Benchmarking;Beta Cell;blood glucose regulation;Body fat;Body Weight decreased;Bone Density;Cell Physiology;Chemosensitization;Clinical;Combined Modality Therapy;comparative effectiveness;comparative effectiveness study;comparative efficacy;Complex;conventional therapy;Data;Defect;Development;Diabetes Mellitus;diabetic patient;efficacy evaluation;efficacy study;efficacy testing;Etiology;exenatide;Failure;Fatty acid glycerol esters;follow-up;gastric inhibitory polypeptide receptor;glargine;Glimepiride;glucagon-like peptide 1;Glucose;Glucose Plasma Concentration;Glycosylated hemoglobin A;Goals;Hyperglycemia;improved;Insulin;insulin secretion;insulin sensitivity;Kidney;Kidney Diseases;liraglutide;Liver;Measurement;Measures;Metabolic;Metformin;Methods;Microvascular Dysfunction;Muscle;Myocardial;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Outcome Study;Patients;Pharmaceutical Preparations;Pioglitazone;Postmenopause;prevent;primary outcome;protective effect;Randomized;Receptor Gene;Recommendation;recruit;Regimen;Risk;Risk Reduction;Role;secondary outcome;Skeletal Muscle;standard of care;Sulfonylurea Compounds;Testing;Therapeutic;Time;Weight Gain;Woman

PROJECT_TITLE: Comparative Effectiveness of Two Initial Combination Therapies in Patients with New Onset Diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE In eukaryotes, the attachment of ubiquitin to histone proteins regulates diverse processes that include transcription, DNA damage repair, and genome stability. To understand how these processes are controlled, we will design sensor molecules to observe ubiquitin attachment to specific histones and to measure their locations and dynamics in the cell nucleus. The strategies and tools we develop will be broadly useful in basic cancer research and will generate new diagnostic capabilities.

PI_NAMEs: COHEN, ROBERT ;SNOW, CHRISTOPHER DAVIS;YAO, TINGTING  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;Adopted;Affinity;Algorithm Design;Ankyrin Repeat;Antibodies;Avidity;BARD1 gene;Basic Cancer Research;Binding;Biological Assay;Biosensor;BRCA1 gene;C-terminal;candidate identification;Cell Nucleus;Cell Physiology;Cells;Chimeric Proteins;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;cost;deep learning algorithm;Defect;design;Detection;Development;diagnostic value;Distal;DNA Repair;Elements;Engineering;Enzymes;Eukaryota;flexibility;Genetic Transcription;Genome;Genome Stability;genome-wide;Genomics;Geometry;Goals;Histones;Image;in silico;In Vitro;in vivo;innovation;interest;Libraries;Location;Lysine;Machine Learning;machine learning algorithm;machine learning method;Maintenance;Malignant Neoplasms;Maps;Measures;meter;Methods;Molecular;Molecular Conformation;Molecular Target;Monitor;Motion;nanomolar;next generation sequencing;novel diagnostics;novel strategies;Nucleosomes;Pathway interactions;Peptides;Play;Polycomb;Positioning Attribute;Post-Translational Protein Processing;Process;Property;Protein Engineering;protein structure;Proteins;Protocols documentation;Reader;Reagent;Reporting;Research Personnel;Role;scaffold;sensor;Series;Signal Transduction;Site;Specificity;Structure;success;System;Technology;Tertiary Protein Structure;Testing;tool;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;ultra high resolution;Validation;Work;Yeasts

PROJECT_TITLE: Machine-Learning Aided Design of Avidity-Based Biosensors of Ubiquitin Signaling

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: NARRATIVE  Food insecurity is present in 11% of the US population, but disparately higher at 33% in the US territory of Puerto Rico that is simultaneously experiencing social and cardiovascular-related inequities, compounded by vulnerability to climate change events. The lack of systematic, longitudinal studies has hindered understanding of the complex mechanistic pathways connecting food insecurity to cardiometabolic disease, posited to operate through biological, diet-related, or psychosocial factors, nor their interconnections with food procurement or climate-change indicators. To address this, we will extend and enrich the existing rigorous and comprehensive data from the highly-productive Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends (PROSPECT), a longitudinal cohort of adults in PR, to generate compelling evidence elucidating the mechanisms between food insecurity and cardiometabolic disease, and to inform programs and policy that can alleviate these inequities in PR, while serving as a model for other populations.

PI_NAMEs: MATTEI, JOSIEMER  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adult;aged;Ancillary Study;Behavior;biobank;Biological;Birth;Blood;Budgets;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Central obesity;Ceramides;Chronic Disease;Church;climate change;clinical examination;cohort;Complex;coping;COVID-19;Data;data access;Data Set;Databases;dehydroepiandrosterone;Diabetes Mellitus;Diet;dietary;Dietary Factors;Dietary Practices;Disasters;Dopamine;Droughts;Dyslipidemias;Eating;Eating Behavior;Enrollment;Epinephrine;Event;experience;Face;Fatty acid glycerol esters;Fatty Acids;Fishes;follow-up;Food;Food Access;Food Analysis;food insecurity;food security;Frequencies;Friends;Goals;Hair;Health;Household;Human Rights;Hunger;Hurricane;Hydrocortisone;Hypertension;indexing;Industrialization;Inequity;Insulin Resistance;Link;Longitudinal cohort;Longitudinal Studies;male;man;Measures;Mediating;men;Mental Depression;Modeling;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel marker;nutrition;Nutritional;Obesity;Observational Study;Participant;Pathway interactions;Persons;Physiological;Plasma;Policies;Population;Prevalence;Price;Productivity;programs;psychologic;Psychological Factors;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Public Health;Publications;Puerto Rico;Questionnaires;Rain;recruit;Reporting;Research;Research Infrastructure;resilience;Resources;Rewards;Risk;Risk Factors;Rural;rural area;Saliva;Sampling;Science;screening;Security;Serotonin;sex;social;Social support;Stress;Surveys;tool;Trans Fats;Trans Fatty Acids;trend;United States;United States Department of Agriculture;Urine;Visit;Vulnerable Populations

PROJECT_TITLE: Longitudinal Mechanisms of Food and Nutrition Security and Cardiometabolic Health in PROSPECT

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cancer;Clinical Research;Genetics;Rare Diseases;Substance Misuse

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because a detailed understanding of the role of Aldh2 and alcohol-induced epithelial cell injury will fundamentally advance the fields of alcohol-related diseases, both benign and malignant. The proposed model systems and findings will provide a platform for new avenues of translational applications related to head-and-neck and esophageal squamous cell carcinomas and other alcohol-induced human pathologies. Thus, the proposed research is relevant to the NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burden of human diseases.

PI_NAMEs: NAKAGAWA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acetaldehyde;Affect;Alcohol consumption;alcohol effect;alcohol exposure;Alcohols;aldehyde dehydrogenases;Allografting;Autophagocytosis;Benign;Biological Models;cancer cell;CD44 gene;Cell Death;cell injury;Cell Survival;Cells;Cellular Stress;chemotherapy;Cisplatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;crosslink;Cytoprotection;Data;Dependence;Development;Disease;DNA biosynthesis;DNA Damage;DNA Interstrand Crosslinking;DNA Repair;DNA Sequence Rearrangement;Doxycycline;Enzymes;Epithelial Cells;Epithelium;Esophageal Squamous Cell Carcinoma;Esophagus;Ethanol;Ethanol Metabolism;Exhibits;Exposure to;FANCD2 protein;Fanconi Anemia pathway;Fanconi's Anemia;Fostering;Functional disorder;Genetic;Genetically Engineered Mouse;Genomic Instability;Genotoxic Stress;genotoxicity;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Homeostasis;human disease;Human Pathology;Hyperactivity;Impairment;inhibitor;innovation;insight;Invaded;knock-down;Knowledge;Left;Lesion;Ligase;Link;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;member;Metabolism;Mission;Mitochondria;Mus;mutant;Mutation;Neoplasm Metastasis;Neoplasms;novel;novel therapeutic intervention;Nuclear;Nucleotides;Oral;Organoids;Oxidative Stress;Parkin;patient derived xenograft model;Patients;pharmacologic;Process;Prognosis;Public Health;Quality Control;Reactive Oxygen Species;repaired;Research;Resistance;Risk;Risk Factors;Role;Squamous cell carcinoma;stem;Testing;Therapeutic;Tissues;translational applications;tumor;tumor initiation;tumor xenograft;tumorigenic;Ubiquitin;United States National Institutes of Health;Validation

PROJECT_TITLE: Aldh2 and epithelial homeostasis and pathobiology

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative  Given that only 2-7% of U.S. health care spending is devoted to primary care, a chronically underfunded but foundational part of the delivery system, states across the country are increasingly adopting policies to increase primary care spending, hoping to slow total spending and improve the quality of care. Four states— Colorado, Delaware, Oregon, and Rhode Island—have enacted legislation or regulations to explicitly raise the percent of health care spending spent on primary care, but the effects of these models on primary care access and continuity, total health care spending, utilization (in and outside of primary care), and quality of care remain largely unknown. This gap in knowledge is increasingly detrimental as many additional states are now debating or designing similar legislation to increase primary care spending; this project addresses this key gap through rigorous quasi-experimental evaluations of the Colorado, Delaware, Oregon, and Rhode Island models, using newer statistical methodology in matching and weighting to improve causal inference.

PI_NAMEs: SONG, ZIRUI  (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Evaluations of Increasing State Investments in Primary Care: Effects on Health Care Spending, Utilization, and Quality

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative This research is relevant to public health because of the increasing prevalence of metabolic disorders, including obesity and type 2 diabetes mellitus. This study will examine the site and mechanisms of glycinergic inhibition in a brain area that regulates energy homeostasis. Completion of the project may result in novel strategies to better manage energy homeostasis via central targets.

PI_NAMEs: DERBENEV, ANDREI  (contact);ZSOMBOK, ANDREA

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adrenal Glands;Adrenalectomy;Area;Autonomic nervous system;blood glucose regulation;Brain;Brain Stem;Central Nervous System;Chronic;Data;Development;Disease;Eating;Electrophysiology (science);Endocrine;Energy Metabolism;experimental study;feeding;Fiber;Fluorescent in Situ Hybridization;GABA transporter;gamma-Aminobutyric Acid;Glucose;glucose tolerance;Glycine;Glycine Receptors;glycine transporter;Goals;High Fat Diet;Homeostasis;improved;in vivo;inhibitory neuron;Knowledge;Light;lipid metabolism;Liver;Maintenance;Maps;Measures;Metabolic;Metabolic Diseases;Mus;Nerve;neural circuit;neuromechanism;neuronal excitability;Neurons;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;novel strategies;Obesity;optogenetics;Organ;Output;paracrine;Pathogenesis;Pathway interactions;Peripheral;Pharmacogenetics;pharmacologic;Physiological;Plasma;Play;Prevalence;Property;Public Health;Regulation;Research;response;Role;Signal Transduction;Site;Slice;Sympathetic Nervous System;Synapses;Testing;Tissues;Tracer;Viral

PROJECT_TITLE: Glycinergic inhibition in the ventral brainstem

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Celiac Disease;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Precision Medicine;Prevention

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Our project, focused on celiac disease and Crohn’s disease, takes a combined genomic and epigenomic approach to pinpoint and understand the mechanisms of action of genetic variants that regulate critical genes specifically in intestinal epithelial cells or in cells of the immune system, and thereby confer increased risk of these common and difficult to treat gastrointestinal conditions. Our research team includes investigators with expertise in molecular genetics, intestinal epithelial cell biology, bioinformatics and statistical genetics, and clinical aspects of these diseases. Using intestinal organoid cultures from biopsies, with and without exposure to disease relevant external stimuli, whole-genome and targeted DNA methylation sequencing, and CRISPR- Cas9 manipulations in tissue culture, we expect that our research will elucidate cell type-specific biological pathways, and gene-environment interactions, that drive the onset and progression of these diseases, with implications for improved prevention and treatment.

PI_NAMEs: HAMILTON, KATHRYN ELIZABETH;TYCKO, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acute;Alleles;Autoimmune;Autophagocytosis;Basic Science;Binding;Binding Sites;Bioinformatics;Biological;Biopsy;bisulfite sequencing;Celiac Disease;Cell Line;cell type;Cells;Cellular biology;Chronic;Clinical;Collaborations;Computational Biology;CRISPR/Cas technology;Crohn's disease;cytokine;Data;Digestive System Disorders;Disease;Disease Progression;disorder prevention;disorder risk;DNA Methylation;DNA methylation profiling;Environment;Epigenetic Process;epigenomics;Epithelial Cells;Exposure to;Future;gastrointestinal;Gastrointestinal Diseases;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;Genomics;Genotype;Germ Lines;Gliadin;Goals;Haplotypes;Heterozygote;Human;Human Cell Line;Immune;Immune response;Immune system;improved;Individual;Individual Differences;Inflammation;Inflammatory;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Link;Loss of Heterozygosity;Maps;Measures;Methylation;Modeling;Molecular;Molecular Genetics;multidisciplinary;Mutate;novel strategies;Organoids;Pathogenicity;Pathway interactions;Patient Care;patient stratification;Phenotype;Point Mutation;polygenic risk score;precision medicine;Predisposition;prevent;Prevention;Proliferating;Reporter;Research;Research Personnel;Risk;risk variant;Role;Sampling;Series;Severities;Signal Transduction;Site-Directed Mutagenesis;SNP genotyping;Specificity;Stimulus;targeted treatment;Testing;tissue culture;Tissues;tool;transcription factor;treatment response;Ulcerative Colitis;United States;Virulence Factors;whole genome;Work

PROJECT_TITLE: Celiac and inflammatory bowel diseases: functional post-GWAS approach

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Social Determinants of Health

PHR: Project Narrative Low-value care (LVC), defined as care where harms or costs outweigh the benefits, is common (nearly half of U.S. patients may receive >1 LVC service every year). LVC can result in physical harm from the service itself, unnecessary follow-up tests/procedures, and needless out-of-pocket costs. The research proposed is a foundational step toward accurately measuring LVC, identifying which LVC services should be prioritized for reduction, and assessing the effectiveness and possible unintended consequences of a program to reduce LVC.

PI_NAMEs: KINI, VINAY  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Accountability;Address;Adopted;Adoption;American Heart Association;Anatomy;Appropriateness Review;Area;beneficiary;bundled payment;candidate validation;Cardiovascular system;care episode;care systems;Caring;Characteristics;Classification;Clinical;Clinical Data;Clinical Practice Guideline;Collaborations;Complex;Coronary Arteriosclerosis;coronary artery calcium;cost;Cost Control;Data;data registry;design;Disparity;effectiveness evaluation;Enrollment;Equilibrium;ethnic minority;experience;Fee-for-Service Plans;follow-up;Frequencies;Guidelines;Health Care Costs;health care disparity;Health Policy;Health system;Healthcare;high risk;Hospitals;improved;innovation;Knowledge;Link;low socioeconomic status;Measurement;Measures;Medical;Medicare;Medicare claim;Modeling;Organizational Models;Outcome;Patient risk;Patients;payment;percutaneous coronary intervention;Policies;Policy Maker;Price;Procedures;programs;Provider;psychologic;racial minority;Recommendation;Reporting;Research;Research Design;Research Personnel;Research Priority;Resources;Rewards;Risk;Sampling;Selection Bias;Services;Stress Tests;Testing;theories;trend;Uninsured Medical Expense;United States National Institutes of Health;Work

PROJECT_TITLE: Measurement and Reduction of Low-Value Cardiovascular Care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Frontotemporal Dementia (FTD);Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Inclusion body myopathies are a devastating muscle disease that has the presence of vacuoles and aggregates on muscle biopsy. We will explore the hypothesis that protein aggregates can spread from myofiber to myofiber leading to muscle degeneration.

PI_NAMEs: WEIHL, CONRAD C (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adaptor Signaling Protein;alpha synuclein;Amyloid;Autophagosome;Biopsy;Biosensor;Brain;Cell Membrane Permeability;Cells;Cessation of life;Coculture Techniques;CRISPR screen;Cytoprotection;Data;Degradation Pathway;Desmin;Disease;Endosomes;Extracellular Space;Failure;Fascicle;Fiber;Fluorescence Resonance Energy Transfer;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;genome-wide;Goals;Grant;Health;Human;Impairment;in vivo;Inclusion Bodies;innovation;Lysosomes;Mediator;Membrane;monomer;Mus;Muscle;Muscle Cells;muscle degeneration;Muscle Fibers;muscle form;mutant;Mutation;Myoblasts;Myopathy;Natural regeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Perimysium;Permeability;Physiological Processes;pre-formed fibril;prion hypothesis;prion seeds;prion-like;Prions;protein aggregation;protein TDP-43;Proteins;Recombinants;Sarcoplasm;Signal Pathway;Signal Transduction;Skeletal Muscle;System;TDP-43 aggregation;Testing;Therapeutic Intervention;transmission process;Ubiquitin;uptake;Vacuole;valosin containing protein mutation;valosin-containing protein;Visualization

PROJECT_TITLE: Protein aggregation in inclusion body and myofibrillar myopathies

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The proposed work benefits public health by systematically assessing the dynamics of the computations un- derlying perceptual decisions using multiple sensory systems and how decisions take into account the uncer- tainty of sensory information, prior knowledge, and changes over time in the environment as well as in the sen- sory systems themselves. A variety of medical conditions can impact both the reliability and accuracy of senso- ry information (e.g., macular degeneration, amblyopia, stroke). The proposed research will improve our under- standing of how sensory inputs from multiple modalities are combined so as to optimize a perceptual decision or a motor plan, and thus can serve to help in the design of rehabilitative plans and sensory-substitution de- vices when sensory input is disrupted (change in bias, gain and/or variability) by disease or other health-relat- ed conditions.

PI_NAMEs: LANDY, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Dynamics of Multisensory Cue Integration

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance We propose to understand how the metabolic state of hair follicle stem cells controls their quiescence and ability to initiate the hair cycle. We will use gain and loss of function approaches to target particular metabolic nodes to understand how they promote or inhibit stem cell activation or the ability of stem cells to initiate tumorigenesis. This work will not only uncover the role metabolic regulation plays in normal tissue, but also how this regulation can influence tumor initiation and wound healing.

PI_NAMEs: CHRISTOFK, HEATHER ;LOWRY, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Affect;Alopecia;cancer cell;cancer initiation;Carcinoma;Cell Maintenance;Cells;chemical carcinogenesis;cofactor;Coupling;Data;dimethylbenzanthracene;Electrons;enzyme activity;enzyme substrate;Enzymes;Epidermis;Epigenetic Process;flexibility;gain of function;Gene Expression;Genetic;Genetic Models;Glutamine;Grant;Growth;Hair;Hair follicle structure;Knockout Mice;Lactate Dehydrogenase;Left;loss of function;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Mitochondria;Molecular;NADH;Normal tissue morphology;oxidation;Oxidation-Reduction;Pathway interactions;pharmacologic;Play;Positioning Attribute;prevent;Production;Pyruvate;Regulation;Role;Signaling Molecule;Squamous cell carcinoma;stem cell fate;stem cell homeostasis;stem cells;Testing;Time;tool;Topical application;tumor;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Work;wound healing

PROJECT_TITLE: Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Women's Health Research

PHR: Project Narrative As the population of the United States ages, increased incidence of age-associated dementias including Alzheimer's disease will become a major public health issue. Interventions that could delay the onset of cognitive decline would have a major public health impact. These studies will help determine mechanisms by which short-term administration of estrogens near the time of menopause could exert lasting benefits to the cognitive health of women as they age.

PI_NAMEs: DANIEL, JILL M (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Age;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attenuated;Award;base;Brain;Cognition;Cognitive;Cognitive aging;cognitive enhancement;Data;delivery vehicle;Dementia;deprivation;Equilibrium;ESR1 gene;Estradiol;Estrogen decline;Estrogen Therapy;estrogen-related receptor;Estrogens;Exposure to;Female;Genes;Genetic Transcription;Goals;Guidelines;Health;Hippocampus;hormone therapy;Hormones;Human;Impaired cognition;Incidence;Insulin-Like Growth Factor I;Intervention;Ligands;long term memory;Long-Term Effects;Maintenance;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mediating;Memory;Menopausal Symptom;Menopause;middle age;midlife estradiol;mouse model;Ovarian;Ovarian hormone;Pathway interactions;Pattern;pharmacologic;PIK3CG gene;Population;Postmenopause;prevent;Proteins;Public Health;Recommendation;Recording of previous events;Regulation;Research;Risk;Rodent Model;Role;Signal Pathway;Signal Transduction;Site;Testing;Time;Transgenic Mice;United States;Viral Vector;Woman;Women's Health;Work

PROJECT_TITLE: Short-term estradiol use in middle-age: implications for female cognitive aging


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Congenital Structural Anomalies;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Smith-Magenis Syndrome (SMS) patients exhibit circadian rhythm disturbance and unruly behavior, such as self-injury, making life difficult for patients and their families. Unfortunately, mouse models of SMS are nocturnal and lack melatonin, a key modulator of sleep, limiting their utility for elucidating the role of the causative gene RAI1 and for therapeutic inventions. The proposed research aims to develop the first diurnal animal model of RAI1 deficiency by deleting RAI1 in diurnal Nile grass rats, which will allow a better understanding of RAI1 and will lead to the development of evidence-based treatment strategies.

PI_NAMEs: IWASE, SHIGEKI  (contact);YAN, LILY

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Alleles;Animal Genetics;Animal Model;Animals;Backcrossings;Behavior;Behavioral;Behavioral Symptoms;Binding Proteins;Biological;Biology;Chromatin;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;cognitive function;conditional knockout;Darkness;Data;Development;Disease;Drowsiness;early childhood;Etiology;Evidence based treatment;Exhibits;experience;Family;FMR1 gene;Functional disorder;Future;Gene Deletion;Gene Expression Regulation;Gene Targeting;Genes;Genetic Diseases;Genome;genome editing;genome sequencing;Genotype;Germ Lines;Goals;Heterozygote;histone-binding proteins;Hormones;Human;Hyperphagia;Impairment;Inbred Strains Mice;Inbreeding;Individual;insight;invention;Knock-out;Knockout Mice;Knowledge;Laboratory mice;Learning;Life;Light;Mediating;Melatonin;Memory;Methyl-CpG-Binding Protein 2;model organism;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Nature;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;novel;Obesity;Patients;Phenocopy;Phenotype;Physiology;Poaceae;Potocki-Lupski syndrome;pre-clinical research;Problem behavior;Production;Rattus;Reporting;Research;response;Resting Phase;Rodent;Rodent Model;Role;Self-Injurious Behavior;Serum;Short-Term Memory;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Wake Cycle;Smith Magenis syndrome;Surveys;Symptoms;System;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;tool;Translating;transmission process;treatment strategy;Tretinoin;Wakefulness;whole genome;Wild Type Mouse

PROJECT_TITLE: Developing a Diurnal Rodent Model for Smith-Magenis Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]