NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

PHR: Project Narrative The field of substance use research lacks racial and ethnic diversity, and few systematic efforts exist to engage undergraduate students in substance use-related research or coursework. This project will engage undergraduates from underrepresented populations in a coordinated program including didactic coursework, intensively mentored research experiences, and professional development activities related to substance use research and careers substance use-related fields. The goal is to broaden the diversity of the next generation of researchers in the field of substance use studies.

PI_NAMEs: GRILLO, WENDY HECK (contact);MARSHALL, SIMON ALEXANDER;MCCLERNON, FRANCIS JOSEPH

PROGRAM_OFFICER_NAME: FERNANDEZ, YOHANSA

PROJECT_TERMS: African American population;Biological;Biomedical Research;career;career development;career networking;Clinical;Collaborations;Communities;curriculum development;demographics;Development;Development Plans;Education;Educational process of instructing;ethnic diversity;Evaluation;experience;Goals;Graduate Education;graduate school;Home;improved;Individual;innovation;Institution;interest;Job Application;Laboratories;Laboratory Procedures;Laboratory Research;meetings;member;Mentors;Minority Groups;multidisciplinary;Neurologist;Neurosciences;next generation;North Carolina;operation;Participant;Population;posters;Privatization;Professional Education;programs;Psychiatrist;Public Health;Publications;racial diversity;Research;Research Ethics;Research Personnel;research study;Research Training;Resources;Science;Series;skills;social;Social Impacts;Societies;STEM career;student participation;Students;substance use;Substance Use Disorder;summer research;Supervision;symposium;Training;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities

PROJECT_TITLE: NCCU Duke - Substance Use Research & Education (ND-SURE)

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The refinement of gross motor skills, such as locomotion, during development is conserved across vertebrate species. The goal of this proposal is to characterize the functional and molecular mechanisms underlying the dopaminergic-mediated refinement of spinal locomotor activity using an established vertebrate model system (larval zebrafish). Since the dopaminergic and motor systems are highly conserved across vertebrates, we expect these findings to translate to other animals, including humans.

PI_NAMEs: MASINO, MARK A (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Agonist;Animals;Behavioral;Biological Models;Calcium;calcium indicator;Complement;Development;differential expression;Dissection;Dopamine;Dopamine Receptor;dopamine transporter;dopaminergic neuron;Electrophysiology (science);Family;Fertilization;Fishes;Functional Imaging;Future;Goals;Human;immature animal;in vivo;Larva;Locomotion;Mammals;Measures;Mediating;Messenger RNA;Molecular;Motor;Motor Activity;Motor Skills;Neurons;neuroregulation;Output;Pattern;Peripheral Nerves;Pharmacology;Polymerase Chain Reaction;Preparation;receptor;Reporting;Reverse Transcription;Role;sensor;Signal Transduction;Source;Spinal;Spinal Cord;Swimming;System;Testing;tool;Transcript;Translating;Tyrosine 3-Monooxygenase;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Functional and molecular dissection of dopaminergic signaling in spinal locomotor circuit development

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Stimulant use disorders and overdose deaths are surging nationwide, and evidence indicates that psychedelics (5-HT2A agonists), such as psilocybin, reduce stimulant use and increase abstinence to a greater degree than psychotherapy alone. We propose to utilize novel selective 5-HT2A tool compounds with full, partial, and biased agonism to investigate the effects on attenuation of methamphetamine self-administration, neuroplasticity, and amotivation. The goal of this proposal is to identify 5-HT2A signaling mechanisms critical for treating drug misuse. 1

PI_NAMEs: HALBERSTADT, ADAM L.;MCCORVY, JOHN D (contact);MURNANE, KEVIN SEAN

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Abstinence;Address;Agonist;Alcoholism;Animal Model;Anxiety;Attenuated;attenuation;Behavior Therapy;Behavioral Model;beta-arrestin;Brain;Chronic;Clinical;clinical efficacy;Clinical Trials;Complication;conditioned place preference;craving;Data;density;design;Desire for food;Dose;drug efficacy;drug misuse;drug seeking behavior;effective therapy;Epidemic;Exhibits;experience;FDA approved;Goals;GTP-Binding Proteins;Hallucinogens;HTR2A gene;Human;In Vitro;in vivo;innovation;Intravenous;Investigation;Learning;Link;Measures;Mediating;Mental Depression;Methamphetamine;methamphetamine effect;Methamphetamine misuse;methamphetamine use;Modeling;Moods;Motivation;neurobiological mechanism;Neuronal Plasticity;Neurons;Nicotine Dependence;novel;NPBWR1 gene;overdose death;Pharmaceutical Preparations;Pharmacotherapy;Play;Psilocybin;Psychological reinforcement;Psychotherapy;receptor;Receptor Activation;Receptor Signaling;recruit;Recruitment Activity;Reversal Learning;Rewards;Rodent;Role;Self Administration;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2C;Signal Pathway;Signal Transduction;stem;stimulant use;stimulant use disorder;stimulant withdrawal;Substance abuse problem;Substance Use Disorder;Surveys;Therapeutic;Therapeutic Effect;tool;Transducers;Treatment Efficacy;United States;Vertebral column;Withdrawal Symptom

PROJECT_TITLE: Investigations into 5-HT2A signaling mechanisms of psychedelic drugs for the treatment of stimulant use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M2)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Narrative Learning the diﬀerence between safety and danger is critical to survival, yet learning and using safety signals is impaired in some psychiatric conditions including posttraumatic stress disorder (PTSD). Safety learning requires plasticity within the insular cortex and the proposed work investigates the nature of safety and danger signal coding in neurons of an anatomically deﬁned amygdala-insula-prefrontal circuit hypothesized to be necessary for learning and using safety signals to regulate fear. Functional and structural insular cortex abnormalities are reported in individuals with PTSD and other psychiatric conditions and the resulting data will inform pathophysiological mechanisms and new avenues for treatment development.

PI_NAMEs: CHRISTIANSON, JOHN PAUL (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acceleration;Amygdaloid structure;Anatomy;base;Behavior;Behavior Control;Behavioral;Behavioral inhibition;behavioral response;Biological;Brain;calcium indicator;Code;Complex;conditioning;Conflict (Psychology);Coupled;Cues;Data;density;Development;Discrimination;Discrimination Learning;Electrophysiology (science);experimental study;Extinction;Failure;Fiber;Freezing;Fright;Functional disorder;Genetic;Glutamates;gray matter;Hippocampus;Image;Impairment;in vivo;Individual;inhibitor;Insula of Reil;Investigation;Learning;Mediating;Methodology;Modeling;Nature;neural circuit;neuromechanism;Neuronal Plasticity;Neurons;novel;Organism;Output;Pattern;Personal Communication;Pharmaceutical Preparations;Photometry;Post-Traumatic Stress Disorders;post-traumatic symptoms;Prefrontal Cortex;prevent;Procedures;Process;Psychopathology;Rattus;receptor;recruit;Regulation;Reporting;Research;Research Personnel;Resources;response;Safety;safety study;sensory input;Severities;Shock;Signal Transduction;Site;sound;Specificity;Stress;Structure;Symptoms;Synaptic plasticity;Testing;therapy development;Time;Virus;Well in self;Work

PROJECT_TITLE: Neural circuit basis of safety learning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: NARRATIVE Hao-Fountain syndrome is a newly identified rare pediatric neurodevelopmental disorder caused by deletions and mutations of the USP7 gene. The patients suffer from global developmental delays, behavioral abnormalities, autism, and variably impaired intellectual development with speech delay. There is currently no cure for this disorder which places a significant burden on both children and parents; therefore, we propose to develop and validate a new human-based model of the Hao-Fountain syndrome that is essential for understanding the molecular mechanisms of the disease, and the discovery of potential treatments for it in the future.

PI_NAMEs: BEZSONOVA, IRINA  (contact);O'NEIL, ALISON LINSLEY

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Angelman Syndrome;autism spectrum disorder;Behavioral;Biological Assay;Biological Models;Brain;Catalytic Domain;Cell Culture Techniques;Cell Differentiation process;Cell model;Child;Childhood;Chromosome 16;Communities;Complex;Defect;Deubiquitinating Enzyme;Deubiquitination;Development;Developmental Delay Disorders;Disease;disease model;Disease Pathway;Down's Syndrome;enzyme activity;Enzyme Kinetics;Evaluation;feeding;Fetus;Fibroblasts;Fountain syndrome;Functional disorder;Future;Genes;global developmental delay;Goals;Histones;Homeostasis;Human;human disease;In Vitro;in vitro activity;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;Intellectual functioning disability;Intellectual impairment;Length;Link;Magnetic Resonance Imaging;Maintenance;MDM2 gene;Measures;Methods;model of autism spectrum disorder;Modeling;Molecular;Morphology;Muscle hypotonia;mutant;Mutation;nerve stem cell;Neurites;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuron development;Neuronal Differentiation;Neurons;Organoids;overexpression;Parents;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;personalized medicine;prevent;Proteins;proteostasis;Regulation;Reporting;Research;Resources;Rodent Model;Sampling;Schizophrenia;Seizures;self-renewal;Speech Delay;stem cell differentiation;stem cell model;stem cells;Structure;success;Testing;Therapeutic;therapeutic target;Time;treatment strategy;Ubiquitin;ubiquitin isopeptidase;ubiquitin-specific protease;Ubiquitination;Variant;Western Blotting;Work

PROJECT_TITLE: Understanding the effect of Hao-Fountain syndrome-causing mutations on neuronal development

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: b. Project Narrative  Age-related liver dysfunction has deleterious effects across multiple tissues, being a central node in whole-body metabolism and tissue cross-talk. This application will use the hepatocyte transplantation technique to manipulate the cellular age of the liver and investigate the effects within the liver and associated secretome.

PI_NAMEs: WHITE, JAMES P. (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Affect;Age;age acceleration;age related;aged;Aging;aging process;Alanine Transaminase;Aspartate Transaminase;Bioinformatics;biological age;Biological Aging;Biological Models;Blood;cell age;Cell Physiology;Cell Transplantation;Cells;Circulation;Clinical;Clinical Markers;Data;dietary restriction;efficacy validation;Engraftment;Epigenetic age;epigenetic clock;Epigenetic Process;experimental study;Exposure to;Genetic Transcription;Genomics;Global Change;Hepatectomy;Hepatic;Hepatocyte;Hepatocyte transplantation;Inbred Strain;indexing;Individual;innovation;Knowledge;Label;Liver;Liver diseases;Liver Dysfunction;liver function;Mass Spectrum Analysis;Measures;Metabolism;Methods;Modeling;Molecular;Molecular Analysis;mouse model;multiple omics;Mus;Natural regeneration;Obesity;old mice;Organ;Parabiosis;Phenotype;Plasma;post-transplant;pro-aging;Procedures;Property;Protein Secretion;Proteins;Proteome;Rejuvenation;Rodent;Serum;Source;Techniques;Testing;Tissues;transcriptome;transcriptomics;transplant model;Transplantation;Urea Nitrogen;Visualization;Work

PROJECT_TITLE: Heterochronic hepatocyte transplantation to rejuvenate the aged liver

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE The overall goal of this proposal is to understand the mechanistic basis of ZFTA-RELA ependymoma, with a specific focus on biomolecular condensates and impact on gene transcription and tumorigenesis. Our studies will also evaluate the contribution of ZFTA-RELA interacting proteins as cell proliferative dependencies, and therapeutic targets.

PI_NAMEs: KRIWACKI, RICHARD W;MACK, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Affinity;Amino Acids;Binding;Binding Sites;Biology;Biophysics;candidate identification;Cell Proliferation;Cells;Chemoresistance;Childhood Brain Neoplasm;Chromatin;Chromatin Structure;Complex;CRISPR screen;Data;Dependence;design;Development;Diagnosis;Disease;DNA;DNA Binding;Drug Targeting;druggable target;Elements;Engineering;Ependymoma;experimental study;Fusion Oncogene Proteins;Gene Expression;Gene Expression Regulation;Gene Fusion;Genes;Genetic Transcription;Genome;genomic locus;Goals;Immunoprecipitation;In Vitro;in vivo;Individual;Knowledge;Link;Liquid substance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Modeling;mouse model;mutant;Mutate;neoplastic cell;new therapeutic target;NMR Spectroscopy;novel;Nuclear;Nuclear Magnetic Resonance;Oncogene Activation;Oncogenic;Operative Surgical Procedures;Outcome;Patients;Phase;Physical condensation;Process;Protein-Protein Interaction Map;Proteins;Radiation;recruit;RELA gene;Relapse;Role;Site;small molecule;Source;Structure;targeted treatment;Testing;Therapeutic;therapeutic target;three dimensional structure;tumor;tumor initiation;tumorigenesis;Validation;Zinc Fingers

PROJECT_TITLE: Discovering the mechanisms underlying oncogenesis by ZFTA-RELA and pinpointing therapeutic targets.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M2)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Stroke can cause permanent learning, memory, and motor deficits. Adult neural stem cells have the capacity to home to the brain injury and are thought to be an important part of the repair process after stroke. This proposal aims to gain a better understanding of processes that influence adult neural stem cells following stroke and to identify future strategies to increase brain repair following stroke.

PI_NAMEs: SAYRE, NAOMI LEDENE (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Administrative Supplement;Adult;Alteplase;American;behavioral impairment;Biological Assay;biological research;Brain;Brain Injuries;brain repair;burden of illness;C-terminal;career;career development;Cell membrane;cell motility;Cell Nucleus;Cell Physiology;chemokine receptor;CXCR4 gene;CXCR4 Receptors;Data;Educational process of instructing;expectation;Future;Genetic Transcription;Goals;Home;improved;In Vitro;in vitro testing;in vivo;Injury;Investigation;ischemic lesion;Ischemic Stroke;Knock-out;Knockout Mice;lateral ventricle;LDL-Receptor Related Protein 1;Learning;Length;Lesion;Ligand Binding Domain;Lipoprotein Receptor;Long term disability;Measures;Mechanics;Mediating;Mediator;Membrane Proteins;Memory impairment;Methods;Middle Cerebral Artery Occlusion;migration;motor deficit;motor recovery;mouse model;mRNA Expression;Mus;Nature;nerve stem cell;Nervous System Disorder;nestin protein;neuroblast;neurogenesis;neuroprotection;Neurosciences;novel;Outcome;Parents;Pathway interactions;Phenotype;Phosphorylation;post stroke;Process;programs;Proliferating;protective effect;protein function;Proteins;receptor;Recovery;Recycling;Regulation;repaired;Research;response;Risk;Role;Running;scaffold;Science;Signal Transduction;Signaling Protein;stem cell biology;stem cell function;stem cell migration;Stroke;stroke patient;stroke recovery;stroke therapy;Tamoxifen;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Thrombectomy;Time;trafficking;Training;Transcriptional Regulation;Transmembrane Domain;Travel;United States

PROJECT_TITLE: Interrogating the role of LRP1 subdomains in neural stem cell function


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: ORONO

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: NARRATIVE: ZEBRAFISH FACILITY EXPANSION UMaine’s Shared Zebrafish Facility is critical for 12 faculty throughout the University of Maine. We propose to expand UMaine’s Zebrafish Facility to accomplish the following: increase nursery space to facilitate rapid growth of new lines, increase spawning space to increase experimental pace, and more than double the capacity of our current system.

PI_NAMEs: HENRY, CLARISSA A (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Address;Award;base;Biology;Biomedical Research;Breeding;Candida;Cell Nucleus;Centers of Research Excellence;Computers;Devices;Discipline;Disease;Dose;Ecology;Engineering;Equipment;experimental study;Faculty;Filtration;Floor;Funding;graduate student;Grant;Growth;Habitats;Housing;human disease;Image Analysis;Influenza;Laboratories;Larva;Letters;Maine;Maintenance;marine;Microscopy;Modeling;Molecular;Monitor;Muscular Dystrophies;Mycoses;new growth;Prevention;Process;Productivity;Pump;rapid growth;Research;Research Personnel;Research Project Grants;Resources;Schools;Science;Side;success;System;teaching laboratory;Technology;Touch sensation;undergraduate student;United States National Institutes of Health;Universities;Water;Work;Zebrafish

PROJECT_TITLE: Zebrafish Habitat Expansion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Chronic Pain;Complementary and Integrative Health;Natural Products;Neurosciences;Opioids;Pain Research

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The overarching goal of this project is to discover novel natural compounds with the potential to inhibit cathepsin L, thereby reducing dynorphin production and offering relief from chronic pain without the risk of addiction. This research has the potential to present a new approach to addressing chronic pain and addressing the opioid crisis. Moreover, it has the potential to pave the way for the creation of innovative pain treatment alternatives that hold significant value for the healthcare sector in Jordan, especially in a context where the availability of options is extremely limited, hence, addressing unmet medical need.

PI_NAMEs: ALMALITI, JEHAD S;GERWICK, WILLIAM HENRY (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: absorption;addiction;Address;Algae;alternative treatment;Analgesics;Area;Artificial Membranes;Attenuated;Biochemical;Bioinformatics;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Cathepsin L;Cell Membrane Permeability;Cells;Cessation of life;Chemical Structure;chronic pain;chronic pain management;chronic pain relief;Collaborations;Crude Extracts;Cyanobacterium;Data;Dimensions;drug candidate;Dynorphins;Enzyme Inhibition;Enzyme Kinetics;Enzymes;Funding;Future;Genomics;Goals;Health Care Sector;High Pressure Liquid Chromatography;High Prevalence;In Vitro;Indigenous;informatics tool;inhibitor;innovation;Jordan;Laboratories;Lead;lead candidate;Libraries;Maps;marine;marine natural product;Mass Spectrum Analysis;Mediator;Medical;metabolomics;Methodology;Middle East;Mining;Modernization;Molecular;Molecular Weight;Natural Compound;Natural product discovery;Natural Products;novel;novel strategies;Opiate Addiction;Opioid Analgesics;opioid epidemic;Pain;Pain management;Permeability;Persons;Pharmaceutical Preparations;pharmacophore;Plant Extracts;Plants;prescription opioid;Process;Production;prodynorphin;Property;repository;Research;Risk;screening;Selection Criteria;small molecule;Source;Spinal;Structure;Students;symposium;Technology;Testing;Time;tool;traditional therapy;Training;training opportunity;United States National Institutes of Health;Universities;water solubility;Work

PROJECT_TITLE: Screening of US and Jordanian Natural Product Libraries for the Discovery of Blood Brain Barrier (BBB) Penetrant Cathepsin L Inhibitors for the Treatment of Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Despite progress in the development of population-specific innovations and culturally-tailored interventions, disparities in access, receipt, and quality of health care delivery persist for populations that have historically been underserved, underrepresented, and marginalized in dissemination and implementation (D&I) research. This is partially due to a lack of harmonization and standardization among health equity language, data elements, and methods. The goal of this research is to develop and validate a taxonomy using stakeholder engagement and machine learning that will serve to prioritize the needs of those impacted by health disparities and inequities, articulate culturally-relevant and population-specific determinants known to influence implementation, and heighten researchers’ ability to assess which health equity issues are being addressed in D&I research and efforts.

PI_NAMEs: BECKER, SARA ;BECKER, WILLIAM C;BROWN, C. HENDRICKS;MCGOVERN, MARK P (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: access disparities;addiction;Address;Adoption;Algorithmic Software;Articulation;Categories;Characteristics;clinical encounter;Code;Collaborations;Communication;Consolidated Framework for Implementation Research;culturally appropriate intervention;Data;Data Element;Data Scientist;Data Set;design;Development;Disease Management;Disparity;Dissemination and Implementation;dissemination science;Ensure;Equity;Exclusion;Feedback;Focus Groups;Future;Goals;Guidelines;health care delivery;health care quality;health determinants;health disparity;health equity;health inequalities;Helping to End Addiction Long-term;implementation determinants;implementation efforts;implementation evaluation;implementation framework;implementation research;implementation science;implementation strategy;indexing;Inequity;innovation;interdisciplinary collaboration;Intervention;Language;Machine Learning;machine learning model;Maps;marginalization;Measurement;member;Mentorship;Methods;Modeling;opioid use disorder;Pain management;Pain Research;parent grant;Participant;Patients;Policies;Population;programs;Provider;Reporting;Research;Research Personnel;Resources;Sampling;social capital;social health determinants;Standardization;Structure;Taxonomy;tool;Training;Transcript;treatment research;Underserved Population;United States National Institutes of Health;unsupervised learning;Visualization

PROJECT_TITLE: Use of topic modeling and stakeholderengagement to map determinants of implementation disparities in addiction and pain research


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Project Narrative The Pediatric Early Phase Clinical Trials Network (PEP-CTN) is a consortium whose mission is to identify and develop effective new agents and treatment strategies for children and adolescents with cancer, through rational and efficient clinical and laboratory research. PEP-CTN clinical trials will incorporate correlative genomics, biology, pharmacology, imaging studies, and patient reported outcomes to help further the understanding of the disposition and action of new treatments for children with cancer. Ultimately, PEP-CTN aims to develop innovative pediatric cancer therapies which are more effective and less toxic. Project Narrative Page 22

PI_NAMEs: FOX, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: SMITH, MALCOLM M

PROJECT_TERMS: Adolescent;Adult;Adverse event;anti-cancer therapeutic;Antibody-drug conjugates;Antigen Targeting;Australia;bi-specific T cell engager;Biological;Biological Models;Biology;Canada;cancer therapy;Cell Therapy;cellular targeting;Characteristics;Child;Childhood;chimeric antigen receptor T cells;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Cohort Studies;Common Terminology Criteria for Adverse Events;Complex;Cytotoxic agent;Data;Databases;Development;DNA Sequence Alteration;Dose;drug action;drug disposition;Drug Exposure;Drug Kinetics;Drug Targeting;early phase clinical trial;early phase trial;Enrollment;Ensure;Evaluation;exome sequencing;Foundations;Gene Targeting;Genes;Genomics;Image;imaging modality;imaging study;Immunotherapy;improved;Infant;Informatics;Infrastructure;innovation;Innovative Therapy;Institution;International;Laboratory Research;Laboratory Study;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Mission;Modeling;Molecular Profiling;Molecular Target;Monoclonal Antibodies;New Agents;novel;novel diagnostics;novel therapeutics;Outcome;Parents;Pathway interactions;Patient Outcomes Assessments;patient population;Patients;Pediatric Neoplasm;Pediatric Oncology;Pediatric Oncology Group;Peer Review;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Pharmacology;Phase;phase 3 testing;Pilot Projects;pre-clinical;Process;Proxy;Radiopharmaceuticals;Reporting;Resources;response;Signal Transduction;Site;Symptoms;System;targeted agent;Therapeutic;therapeutic development;therapeutic target;Toxic effect;transcriptome sequencing;treatment strategy;tumor;tumor DNA;young adult

PROJECT_TITLE: Children's Oncology Group Pediatric EarlyPhase Clinical Trial Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M3)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Pancreatic ductal adenocarcinoma is one of the leading causes of cancer related deaths in the United States, with limited options for therapy. Our proposed research will investigate how cancer cells use the nuclear cytoplasmic trafficking pathway to promote cellular growth and metastasis. This proposal will advance our understanding of the mechanisms that contribute to PDAC development and progression and identify potential therapeutic targets.

PI_NAMEs: BANNOURA, SAHAR  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: advanced disease;Affect;Alternative Splicing;Amino Acids;Animal Model;anti-cancer research;Attenuated;Automobile Driving;Binding;Bioinformatics;Biological Markers;Biology;cancer cell;Cancer Etiology;Cancer Model;cancer type;cell growth;Cell Nucleus;Cell Proliferation;Cells;Cessation of life;Chromatin;Chromosome Condensation;Complex;Confocal Microscopy;CRISPR/Cas technology;Cytoplasm;Cytosol;Data;Development;Diagnosis;differential expression;Disease;Disease Progression;Disseminated Malignant Neoplasm;DNA Repair;Event;fatty acid metabolism;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;GTP Binding;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Image;Impairment;improved;insight;knock-down;Knock-out;KPC model;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Microscopy;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Newly Diagnosed;novel;Nuclear;nucleocytoplasmic transport;Operative Surgical Procedures;Organ;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;Phase;Postdoctoral Fellow;Process;Prognosis;Proliferating;Proteins;Proteome;Proteomics;Regulation;Research;Research Project Grants;RNA;RNA Processing;RNA Splicing;RNA Transport;Role;Running;Science;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Stains;targeted treatment;Testing;therapeutic development;therapeutic target;Tissues;trafficking;Training;transcriptome;transcriptome sequencing;transcriptomics;Transport Process;treatment and outcome;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;United States;Validation;Visualization

PROJECT_TITLE: The Role of Guanine Exchange Factors in Pancreatic Ductal Adenocarcinoma (PDAC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Recovery Support Services;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This application is submitted in response to RFA-DA-053 with the overall aim of accelerating the translation of research to practice reduce overdose risk for women during community re-entry following release from prison through the adaptation and testing of an innovative, trauma-informed, relational intervention approach. The proposed study closely aligns with NIDA’s funding priority area NOT-DA-23-007 to improve substance use outcomes for individuals with a history of violence.

PI_NAMEs: KNIGHT, KEVIN ;STATON, MICHELE  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Acceleration;Address;Administrator;Adolescent;Adult women;Alcohols;Area;Cessation of life;Collaborations;Communities;community reentry;Complex;coping;Coping Skills;Data;Death Rate;Disproportionately impacts women;Drug Screening;early life adversity;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation design;emotion regulation;Exclusion;experience;feasibility testing;Focus Groups;Funding;Gender;General Population;Group Processes;Helping to End Addiction Long-term;High Risk Woman;Hybrids;implementation determinants;Imprisonment;improved;improved outcome;Individual;individualized medicine;innovation;Intervention;Justice;Kentucky;Legal system;Lived experience;Marijuana;men;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid misuse;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;Patient Self-Report;Pharmaceutical Preparations;Phase;pilot test;Preparation;Prevention approach;primary outcome;Prisons;Public Health;Randomized;Recording of previous events;Recovery;Recovery Support;Reporting;Research;Research Personnel;research to practice;response;Risk;Risk Reduction;Screening Result;secondary outcome;Site;Speed;substance use;Substance Use Disorder;support network;Symptoms;Testing;Texas;therapy design;Time;Translational Research;Trauma;treatment as usual;treatment program;Trust;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;Urine;Victimization;Violence;violence exposure;Woman;women versus men;Women's Group;Women's mortality;Youth

PROJECT_TITLE: An innovative, trauma-informed approach for reducing overdose risk among women re-entering the community from prison

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Though DNA viruses infect every human, most individuals do not show any initial symptoms, yet others develop complex diseases. Here, we will develop new data science and experimental methods to understand why individuals respond differently to the same infections by mapping the individuals, tissues, and cells that harbor latent viruses. Applications of our new methods will uncover new interactions between the viruses and host genetics, individual cells, and human phenotypes—all key ingredients in understanding the impact of the human DNA virome on health and disease.

PI_NAMEs: LAREAU, CALEB ANDREW (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acceleration;Acute;Address;Attenuated;base;Benchmarking;Binding;biobank;bioinformatics tool;Biological Assay;Biology;Blood;Cell Line;cell type;Cells;chemotherapy;chimeric antigen receptor T cells;Clinical;cofactor;cohort;Collaborations;Complex;Computing Methodologies;cost;Coupled;Data;Data Science;Data Set;Development;digital;Disease;DNA;DNA mapping;DNA Sequence;DNA sequencing;DNA Virus Infections;DNA Viruses;Genetic;genetic analysis;genetic strain;genetic variant;Genetic Variation;genome sequencing;genomic tools;Genomics;Genotype;Geographic Locations;Health;Human;human data;human disease;human DNA;Human Herpesvirus 6;human old age (65+);human RNA sequencing;human tissue;human virome;Immune system;Individual;infancy;Infection;Integration Host Factors;latent infection;Lead;Life;Link;Maps;Measurement;Measures;Metadata;Methodology;Methods;Molecular;multiple omics;next generation sequencing;novel;novel therapeutics;pathogen;Pathway interactions;Phenotype;Population;programs;Property;reactivation from latency;Resolution;Resources;RNA Sequences;Sampling;Sequence Read Archive;seropositive;sex;single cell genomics;stable cell line;Symptoms;technological innovation;Technology;technology development;tissue tropism;Tissues;trait;transcriptome;Tropism;Variant;Viral;viral DNA;Viral reservoir;virome;Virus;Virus Diseases;Virus Latency;whole genome;Work

PROJECT_TITLE: The Human DNA virome: from petabase scale to single-cell resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-E (50)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Our U2C/TL1 program fosters a rigorous approach to scientific inquiry in the areas of basic, translational and clinical investigation, while providing programs for professional development and networking opportunities. Our trainees publish novel science, attain fellowship and career development awards, and transition to independent research careers. Our goal is to train a new generation of scientists to be future leaders in the fields of nephrology, urology and hematology.

PI_NAMEs: HO, JACQUELINE ;JHAMB, MANISHA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;analytical tool;Area;base;Basic Science;Benign;Biological;Biological Sciences;Biomedical Engineering;Biomedical Research;Blood Vessels;career;career development;Childhood;Clinical;clinical investigation;Clinical Sciences;cohort;Collaborations;college;Communication;Communities;Community Outreach;Complement;Computational Biology;design;Development;disability;Discipline;Disease;Doctor of Philosophy;doctoral student;Electrolytes;Engineering;Ensure;Environment;experience;Faculty;Fellowship;forging;Fostering;Funding;Future;Generations;Goals;graduate school;Grant;Growth;Growth and Development function;Health;Hematological Disease;Hematology;high school;improved;Individual;Industry;Institute of Medicine (U.S.);Interdisciplinary Study;Investigation;Journals;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;knowledge base;lectures;Machine Learning;Manuscripts;Mechanics;medical schools;Medicine;meetings;member;Mentors;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;novel;novel diagnostics;novel strategies;novel therapeutics;Oncology;Pathogenesis;Patient Care;Pediatric Hematology;Physicians;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health Schools;Publishing;Recording of previous events;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;resilience;Resource Development;Resources;Review Literature;Robotics;Science;Scientific Inquiry;Scientist;skills;Structure;student training;Students;Supervision;Thinking;TNFSF15 gene;tool;Training;training opportunity;Training Programs;Training Support;Transition Career Development Award (K22);Translational Research;undergraduate student;Underrepresented Populations;Universities;Urologic Diseases;Urology;Work;working group;Writing

PROJECT_TITLE: PCT-KUH: Pittsburgh Center for Training in Kidney, Urology and Hematology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-3 (M1)]


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: SIMS-LUCAS, SUNDER  (contact)

PROJECT_TITLE: PCT-KUH: Pittsburgh center for training in kidney, urology and hematology


PI_NAMEs: JHAMB, MANISHA  (contact)


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric

PI_NAMEs: HO, JACQUELINE  (contact)

PROJECT_TERMS: Address;American Indians;Area;Award;Benign;Biomedical Research;Black race;career;career development;Clinical Research;Collaborations;college;Communities;community building;Community Outreach;County;Data Science;design;digital platform;Discipline;Education;Educational workshop;Engineering;Environment;experience;Fellowship;Funding;Funding Opportunities;Goals;Health Services Research;Hematology;high school;High School Student;Hispanic;Individual;Joints;Kidney;Leadership;life span;Medical;Medical Students;Medicine;member;Mentors;Mentorship;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;outreach;outreach program;peer;peer coaching;physician-scientist training program;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Support;Residencies;Schools;Science;Scientist;Series;skills;social media;Societies;Structure;student training;Students;summer research;summer student;symposium;TNFSF15 gene;Training;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;Universities;Urology;Vertebral column;virtual platform;web site;Woman;Work


NIH_SPENDING_CATS: Cancer

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: Modernization of SPF Rodent Housing in Shared-Use Animal Facility at Einstein The Albert Einstein College of Medicine Institute for Animal Studies provides comprehensive support for the generation, housing, and analysis of animal models of human disease and transgenic animals used in both basic and translational research relevant to public health. We propose to establish a specialized sub-facility to house immunocompromised, immunodeficient, and transgenic animals used in studies conducted by researchers affiliated with several NIH-funded Centers. In this sub-facility, we will replace racks and static, filter-top cages with new racks that support the use of individually ventilated cages, which will enhance the biosafety of the animal microenvironment by ensuring the adequate flow of sterile air, reduce the frequency at which cages require changing, and increase the overall housing capacity of the facility to meet increasing interest in and usage of preclinical animal model development.

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Aging;Air;air filter;Air Movements;American;animal care;Animal Experiments;animal facility;Animal Housing;Animal Husbandry;Animal Model;animal model development;Animal Welfare;Animals;Basic Science;Biomedical Research;Board Certification;Cancer Model;Caring;college;Compensation;Comprehensive Cancer Center;Control Animal;Dangerousness;density;Development;Diabetes Mellitus;Educational process of instructing;Ensure;Equipment;experience;flexibility;Frequencies;Funding;Generations;germ free condition;Health;high efficiency particulate air filter;House mice;Housing;Human;human disease;human model;Humidity;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;improved;Individual;Infection;Institute of Medicine (U.S.);interest;International;Knockout Mice;Laboratory Animals;Medicine;Methods;Modernization;Monitor;mouse model;National Cancer Institute;Oncogenes;operation;Pathologist;Policies;pre-clinical;pre-clinical research;prevent;Public Health;recruit;Regulation;Reproducibility;Research;research facility;Research Personnel;Research Support;Risk;Rodent;Safety;Schedule;Services;Sterility;Stress;System;Temperature;Transgenic Animals;Transgenic Organisms;Translational Research;United States National Institutes of Health;vapor;ventilation;Veterinary Pathology

PROJECT_TITLE: Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-related Operations


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative We plan to initiate participation in the NIH U01 Consortium for Gut-Brain Communication in Parkinson’s Disease (GBPDC) including contribution of patients into the where they will be phenotyped with in depth Parkinson’s and GI measures including clinical symptoms and physiology. Subsets of the cohort will be recruited from the Massachusetts General Hospital (MGH) to participate in studies of brain gut imaging to assess meal-induced gut-brain axis and autonomic alterations in PD and another subset will under detailed sleep, circadian rhythm, GI motility pattern assessment to understand the relationship between Parkinson’s disease desynchrony of central and peripheral circadian and sleep clocks with GI dysmotility.

PI_NAMEs: KUO, BRADEN  (contact);VIDENOVIC, ALEKSANDAR

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: absorption;actigraphy;Affect;Age;alpha synuclein;Amaze;Brain;Brain Stem;Caring;Central Nervous System;Characteristics;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Research;cohort;Collection;Colon;Data;Dependence;Deterioration;Disease;disorder control;dopaminergic neuron;Enteral;experience;Functional disorder;Functional Magnetic Resonance Imaging;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal tract structure;Gastroparesis;General Hospitals;Goals;gut-brain axis;Health;Hour;Human;Image;innovation;Inpatients;Intervention;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Melatonin;microbiome;Motility;motility disorder;motor deficit;Movement Disorders;Nausea;Nerve;Nervous System;neural circuit;Neurodegenerative Disorders;Outcome;Parkinson Disease;Participant;Pathologic;Pathologic Processes;patient population;Patient Recruitments;Patient Selection;Patient Self-Report;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Physiology;Polysomnography;poor sleep;Population;potential biomarker;Quality of life;Questionnaires;Radionuclide Imaging;recruit;Registries;Reporting;Research;response;sex;Signal Transduction;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;stem;Stomach;Substantia nigra structure;Symptoms;System;Testing;Thick;United States National Institutes of Health;Vomiting

PROJECT_TITLE: A Consortium for Gut-Brain Communication in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Loss of neurons that produce the neuromodulatory neurotransmitter acetylcholine in the basal forebrain are correlated with cognitive decline in Lewy Body Dementia, and loss of these neurons is predictive of patients with Parkinson’s Disease developing Parkinson’s Disease Dementia. This project aims to understand how loss of acetylcholine release or signaling in mouse models of Lewy Body Dementia lead to cortical dysfunction and subsequent cognitive decline. The successful completion of this project will not only lead to a better understanding of how cortical dysfunction leads to cognitive decline, but will also lead to a better understanding of how to leverage cholinergic signaling for novel therapeutics in Lewy Body Dementia.

PI_NAMEs: MOEHLE, MARK S (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;alpha synuclein;Alzheimer's Disease;Basal Cell;basal forebrain;Behavioral;Brain;Brain region;Cell Nucleus;Cells;cholinergic;comparison control;Dementia;Dementia with Lewy Bodies;Electrophysiology (science);Executive Dysfunction;executive function;experimental study;Functional disorder;Glutamates;Health;Impaired cognition;Lead;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Link;Long-Term Depression;Medial;Modeling;mouse model;Mus;Muscarinic Acetylcholine Receptor;neuron loss;Neurons;neuroregulation;Neurotransmitters;Nicotinic Receptors;novel therapeutics;Output;Parkinson Disease;Parkinson's Dementia;Pathologic;Patients;pre-formed fibril;Prefrontal Cortex;Property;Pyramidal Cells;Research;Role;Series;Signal Transduction;synucleinopathy;Testing

PROJECT_TITLE: Supplement to Promote Diversity in Health-Related Research


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Craniosynostosis, premature fusion of skull bones, is one of the most common human craniofacial birth defects. We have created a zebrafish model for one of the genetic defects that causes craniosynostosis in humans, and through study of the zebrafish, aim to better understand the genetic and cellular events that lead to defective skull development. Our findings will aid in providing better counseling to families and in developing more targeted therapies for these patients.

PI_NAMEs: FISHER, SHANNON  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Affect;Binding;Binding Sites;Biological Assay;bone;Candidate Disease Gene;Cartilage;Cell Culture Techniques;Cell model;Cells;Cephalic;Childhood;Chromatin;Congenital Abnormality;Connective Tissue;Consensus;coronal suture;Counseling;craniofacial;craniofacial development;craniofacial tissue;Craniosynostosis;cranium;Data;Defect;Development;dynamical evolution;Embryo;Enhancers;epigenomic profiling;ETS2 gene;Event;experimental study;Family;Family member;Fishes;Frontal bone structure;Future;Gene Mutation;Genes;Genetic;Genetic Markers;Genetic Risk;Genetic Transcription;genome-wide;genomic profiling;Genomics;Growth;Heterozygote;Human;Human Genome;Hybrids;Image;in vivo;insight;Modeling;Mus;mutant;Mutation;Organism;Osteoblasts;osteogenic;Parietal bone structure;Pathogenesis;Patients;Phenotype;Play;Population;precursor cell;premature;prevent;Process;Regulation;Repression;Risk;risk variant;Role;Sample Size;Severities;Signal Transduction;Site;skeletal;Specificity;Specimen;Surgical sutures;suture fusion;targeted treatment;Techniques;Testing;therapeutic target;Tissues;transcription factor;Transcription Repressor;Transgenic Organisms;Tretinoin;Yeasts;Zebrafish

PROJECT_TITLE: Genomic regulation in ERF-related craniosynostosis

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Chicago

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The ability to sustain gene expression homeostasis, is one of the most integral parts of cellular biology but declines with age. In a well-received preprint, the project investigator discovered that most organs of 24 months old mice, and lungs infected with influenza A, display a genome-wide imbalance in the transcript levels encoded by short genes relative to those encoded by long genes. This project will address the regulation of this transcriptome imbalance and its impact on the functional health of the proteome and the multi-morbidity in aged individuals.

PI_NAMEs: STOEGER, THOMAS  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Adult;age related;age related changes;age related decline;aged;Aging;aging morbidity;aging population;animal old age;Area;Biochemical;Bioethics;biological adaptation to stress;Biology of Aging;Brain;Buffers;Cause of Death;cell age;Cell Line;Cell Physiology;Cellular biology;Cellular Stress;Collaborations;Communicable Diseases;Complex;Data;Data Science;Data Scientist;Data Set;Disease;Drug Screening;Economic Burden;Elderly;Elements;Embryo;Ensure;Epithelium;Failure;Foundations;Functional disorder;Funding;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Genome;genome-wide;Genotype-Tissue Expression Project;Geroscience;Global Change;Glutamine;Grant;Health;healthspan;Heat-Shock Response;Heterozygote;Homeostasis;Human;Human Cell Line;Immune;immune function;Immunologist;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammatory Response;influenza A pneumonia;Influenza A virus;influenza infection;innovation;interest;Intervention;Laboratories;Lead;Learning;Learning Skill;Length;Life;Link;loss of function;Lung;Lung Diseases;Lung infections;Machine Learning;Macromolecular Complexes;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multiple chronic conditions;Mus;normal aging;novel;novel strategies;old mice;Older Population;Organ;overexpression;pathological aging;Pathway interactions;Phase;Pneumonia;pneumonia model;Polymerase;post-doctoral training;Postdoctoral Fellow;Predisposition;Printing;Process;programs;Proline;Proteome;proteostasis;Publishing;Recovery;Regulation;Reporting;Research;Research Personnel;resilience;resilience in aging;response;RNA;RNA metabolism;RNA Splicing;Running;Scientist;Site;social;Stimulus;stoichiometry;Stress;Supervision;System;Systems Analysis;Techniques;Testing;Tissues;Training;Training Programs;Transcript;transcriptome;transcriptome sequencing;transcriptomics;United States;Up-Regulation;Virus Diseases;Work;Writing

PROJECT_TITLE: Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Prevention;Vaccine Related

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Acinetobacter baumannii is an important cause of multi-drug resistant nosocomial and combat related infections with high mortality. Immunotherapeutic alone or in combination with drugs can be a solution to prevent and treat MDR Acinetobacter infection. We propose to evaluate the potency of novel chimeric polypeptide vaccines against pneumonic Acinetobacter infection and delineate protective immunity to provide insights into the immunotherapeutic design against this emergent MDR bacterial pathogen.

PI_NAMEs: ARULANANDAM, BERNARD PRAGASH (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Acinetobacter Infections;Address;Antibodies;Antibody Activation;Antibody-mediated protection;Antigens;antimicrobial;Attenuated Vaccines;B Cell Proliferation;B-Lymphocyte Epitopes;B-Lymphocytes;Bacterial Infections;bactericide;Biological Assay;Biological Markers;Blood Circulation;Bone Marrow;C57BL/6 Mouse;Catheters;Cells;Clinical;Clone Cells;combat;Complement;Complement Activation;design;Development;effectiveness evaluation;efficacy evaluation;Epitopes;Evaluation;Flow Cytometry;Future;Goals;Gram-Negative Bacteria;Health;Helper-Inducer T-Lymphocyte;Histopathology;HLA-DR4 Antigen;Human;Humoral Immunities;IL5 gene;Image Cytometry;Immune;Immune Sera;Immunity;Immunization;Immunize;Immunocompromised Host;immunogenic;immunogenicity;Immunotherapeutic agent;improved;In Vitro;in vivo;Individual;Infection;insight;Interleukin-4;Interleukin-5;Intervention;intraperitoneal;Knowledge;Licensing;live cell imaging;Lung;Lung infections;Macrophage;Mediating;Monoclonal Antibodies;mortality;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Mus;neutrophil;Nosocomial Infections;novel;Passive Immunization;pathogenic bacteria;Pathology;Pathway interactions;Peptides;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;polypeptide;Predisposition;prevent;Preventive measure;Preventive vaccine;protective efficacy;Proteins;Reaction;Reporting;Resistance;Role;Route;Safety;Serum;subcutaneous;Subunit Vaccines;Survival Rate;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Transgenic Mice;TXN gene;uptake;Urinary tract infection;Vaccinated;Vaccination;vaccine development;vaccine efficacy;vaccine evaluation;vaccine platform;Vaccines;vaccinology;ventilator-associated pneumonia;Virulence Factors;wound

PROJECT_TITLE: Evaluation of a polypeptide vaccine against Acinetobacter infection

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Realizing the promise of genomic medicine to improve disease diagnosis, predict outcomes, and guide treatment for the entire population depends on engaging and educating individuals from underrepresented and diverse backgrounds. This R25 renewal application proposes to leverage and build on the environment and expertise at UAB to develop the Summer Undergraduate and Postbacc Experiences in Genomic Medicine (SUPER-GM), built off of the foundation from our prior Summer Undergraduate Research Experiences in Genomic Medicine (SURE-GM) program which had 46 scholars from 9 historically black colleges or universities (HBCUs) in the region successfully participate. SUPER-GM is SURE-GM reimagined as a summer program with a year-long possible postbacc extension tailored for HBCU undergraduate students that will provide more scholars with the necessary skills, exposure, and experiences to succeed in graduate and/or professional training in genomic sciences.

PI_NAMEs: LASSEIGNE, BRITTANY NICOLE (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Address;African American population;Alabama;Award;Biomedical Research;career;career development;career networking;Communities;Counseling;Coupled;design;Development;Development Plans;disadvantaged background;disease diagnosis;Education;Environment;Expenditure;experience;Faculty;Foundations;Funding;genome sciences;Genomic medicine;Goals;Graduate Education;graduate school;Grant;health care disparity;higher education;Historically Black Colleges and Universities;Home;Immersion;improved;Individual;Institution;International;meetings;Mentors;Names;National Human Genome Research Institute;news;outcome prediction;Periodicals;Persons;Physicians;Population;Positioning Attribute;Postbaccalaureate;Principal Investigator;Privatization;Process;programs;Qualifying;recruit;Reporting;Research;research and development;Research Project Grants;Research Training;Role;Scholars Program;Schools;Science;science and society;Scientist;skills;Students;summer program;summer research;System;Training;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Underserved Population;underserved students;United States National Institutes of Health;Universities;university student;virtual

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M3)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative Non-motor symptoms in Parkinson’s disease (PD) are common and burdensome throughout disease course but are not well studied in racial and ethnic minority populations. This study will investigate race and ethnicity differences of non-motor symptoms among Black/African American and Latino populations with PD. The occurrence, treatment, and burden of non-motor symptoms will be evaluated among these historically underrepresented PD populations using observational study and electronic health records data.

PI_NAMEs: VENUTO, CHARLES STANLEY (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Address;Affect;African;African American;African American population;Autonomic Dysfunction;Black race;Bradykinesia;Brain Diseases;Cessation of life;Chronic;Clinical;Clinical Research;Clinical Trials;Communities;Data;Data Sources;Decentralization;disability;Disease;disease heterogeneity;Disparity;Electronic Health Record;Enrollment;ethnic difference;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Etiology;Evaluation;experience;Frequencies;Future;Goals;health care service organization;health record;Impaired cognition;improved;Individual;insight;Knowledge;Latino;Latino Population;member;Minority Groups;Minority Participation;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuropsychiatric symptom;non-motor symptom;Observational Study;Odds Ratio;Parkinson Disease;Participant;Patient Self-Report;Patients;Persons;Pharmacological Treatment;Population;posture instability;Quality of life;Race;racial difference;racial diversity;racial minority;racial minority population;racial population;Recommendation;Reporting;Research;Research Project Grants;research study;Sample Size;Severities;Sleep Disorders;Source;study population;Symptoms;therapeutic development;treatment strategy;Tremor;Underrepresented Populations;United States;Variant;World Health

PROJECT_TITLE: Racial and Ethnic Differences of Non-Motor Symptoms in Parkinson's Disease

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative There is currently no effective treatment for motor neuron (MN) disorders in part due to a lack of understanding of the molecular mechanisms that allow distinct MN subtypes to acquire and maintain their function-defining properties. We recently identified several evolutionarily conserved regulatory factors (e.g., UNC-3, BNC-1, PBRM-1) that control MN subtype development and function, and the proposed research will employ cutting-edge methods to illuminate their molecular mechanism of action. Completion of these experiments will advance our understanding of how MNs become and remain functional, aiming to provide key insights into the etiology, diagnosis or treatment of MN disorders.

PI_NAMEs: KRATSIOS, PASCHALIS  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Activator Appliances;Adult;Amyotrophic Lateral Sclerosis;Auxins;Basic Science;Binding;Binding Sites;Biological Models;Brain Stem;Caenorhabditis elegans;Cell Adhesion Molecules;cell type;Cells;cholinergic;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Code;CRISPR/Cas technology;Data;Defect;Development;Developmental Delay Disorders;Diagnosis;differential expression;Disease;Ectopic Expression;effective therapy;Embryo;Endowment;Ensure;Etiology;Event;experimental study;fly;Genes;Genetic Models;Genetic Screening;Genetic Transcription;genome-wide;Goals;Human;Human Pathology;Individual;insight;Ion Channel;knock-down;Lead;Life;Light;Locomotion;Maintenance;Membrane;Methods;model organism;Molecular;Molecular Mechanisms of Action;Morphology;Motor;motor control;motor neuron development;Motor Neuron Disease;motor neuron function;Motor Neurons;Mus;Mutate;Mutation;Nematoda;Nerve;Nervous System;Neurons;Neuropeptides;Neurotransmitter Receptor;Orthologous Gene;Outcome;Predisposition;prevent;Property;Proteins;receptor;Repression;Research;Role;Secure;Spinal;Spinal Cord;Spinal Muscular Atrophy;Syndrome;System;Testing;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Molecular mechanisms of motor neuron terminal identity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Dietary Supplements;Major Depressive Disorder;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Rehabilitation

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Aging is associated with a decline in cognition and the onset of disabling diseases such as dementia. The current investigation will investigate whether mushrooms consumption is associated with reduced incidence of cognitive decline in a cohort of middle-aged and elderly individuals.

PI_NAMEs: MUSCAT, JOSHUA E (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Activities of Daily Living;Adult;Age;age related;Aging;aging population;Alzheimer's Disease;Amino Acids;Animals;Anti-Inflammatory Agents;Antioxidants;Area;Asia;Betaine;Biological;Blood;Blood specimen;brain cell;Cells;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Cohort Studies;Consumption;Data;Dementia;Diet;Diet Records;dietary;Digit structure;Disabling;disabling disease;Disease;Elderly;Equation;experience;Food;functional food;functional loss;fungus;Genes;Glutathione;Goals;good diet;Health;Human;human population study;Immune;Impaired cognition;Incidence;Individual;insight;Intake;Intelligence;interest;Investigation;Japan;Japanese;Japanese Population;Link;Longevity;Longitudinal cohort;Longitudinal Studies;Maintenance;Major Depressive Disorder;Measures;Mediation;Medical;Medical Records;men;Mental Depression;mental state;Metabolic Diseases;middle age;Modeling;Nerve Degeneration;Neurocognitive;neuropsychiatric disorder;novel;Nutrient;nutrition;Nutrition Assessment;Nutritional;nutritional approach;Organic Cation Transporter;Outcome;Oxidative Stress;Participant;Pathway interactions;Persons;Physiological;Plants;Population;prevent;Prevention;prospective;Questionnaires;rapid growth;Risk;Risk Reduction;Role;Science;Source;success;Surveys;Taste Perception;Testing;Tissues;United States;uptake;Woman

PROJECT_TITLE: Longitudinal cohort of mushroom intake and cognitive function in the elderly

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: This project develops a new approach to monitoring blood pressure in patients with a life threatening condition known as circulatory shock, which can be caused by many causes including heart failure, overwhelming infection, or bleeding. The method uses computational techniques to provide an improved description of the actual perfusion pressure driving blood flow to vital organs during shock, and may therefore be used to guide clinical diagnosis and management of therapies aimed at treating shock. The project will combine studies from preclinical animal models and clinical patients to validate the new approach.

PI_NAMEs: AGUIRRE, AARON D (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Admission activity;animal data;Animal Experiments;Animal Model;Automobile Driving;Beds;Blood flow;Blood Pressure;Blood Pressure Monitors;Cardiac Output;Cardiac Surgery procedures;Cardiogenic Shock;Cessation of life;Circulation;Clinical;clinical care;clinical database;clinical decision support;clinical decision-making;clinical diagnosis;Clinical Management;clinical practice;Clinical Trials;cohort;comorbidity;computational pipelines;Computational Technique;Consensus;convolutional neural network;Critical Care;Critical Illness;Data;Data Collection;Databases;design;Diagnosis;Disease;Drops;Electroconvulsive Therapy;Electronics;Elements;Feedback;Foundations;Future;General Hospitals;Goals;graphical user interface;hands-on learning;Heart failure;hemodynamics;Hemorrhage;Hemorrhagic Shock;Image;improved;Individual;Infection;Intensive Care Units;Intervention;Label;Life;Liquid substance;Massachusetts;Measures;Medicine;Methods;Modeling;mortality;Nature;novel;novel strategies;Organ;organ injury;Organ Model;patient population;Patients;Pattern;Perfusion;Pharmaceutical Preparations;pharyngeal critical pressure;Phenotype;Photoplethysmography;Physiologic Monitoring;Physiological;Physiology;porcine model;pre-clinical;preclinical study;pressure;prevent;Property;prospective;randomized, clinical trials;response;Resuscitation;risk prediction;Sepsis;Severities;Shock;Signal Transduction;standard of care;support tools;targeted treatment;Testing;theories;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissues;Titrations;Training;transfer learning;treatment guidelines;trial design;vascular bed;Vasoconstrictor Agents

PROJECT_TITLE: Tissue Perfusion Pressure for Improved Management of Circulatory Shock

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Neurosciences;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Response to immunotherapy remains less than 20% for Oral Cavity Squamous Cell Carcinoma (OSCC). Neurotransmitters of the parasympathetic nervous system, such as Acetylcholine (Ach), can be secreted from non-neuronal tissues, including lymphocytes, which are abundant in microenvironment of OSCC and are essential to mediating responses to immunotherapy. This project aims to understand how non-neuronal Ach signaling maintains the homeostasis of lymphocytes with a goal of uncovering novel targets to improve responses to immunotherapy.

PI_NAMEs: WHITE, RUTH A (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acetylcholine;Animal Model;anti-tumor immune response;Antigens;autocrine;Binding;Biological Assay;carcinogenesis;CD8-Positive T-Lymphocytes;Cell secretion;Choline O-Acetyltransferase;cholinergic;Cholinergic Receptors;CHRM1 gene;Chronic;Clinic;Cytotoxic T-Lymphocytes;Data;Development;Environment;Enzymes;exhaustion;Exposure to;Failure;Functional disorder;Future;Goals;Growth;Homeostasis;Immune;immune checkpoint blockade;Immunofluorescence Immunologic;Immunotherapy;Impairment;improved;Incidence;Infiltration;innovation;Kinetics;Knowledge;Lymphocyte;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Mediating;Memory;Modeling;mouse model;mouth squamous cell carcinoma;Mus;Muscarinic Acetylcholine Receptor;Muscarinic Agonists;Muscarinics;Neurotransmitters;Nicotinic Receptors;novel;novel strategies;Oral Stage;Parasympathetic Nervous System;Pathway interactions;Patients;Phenotype;Population;pre-clinical;prevent;Production;Proliferating;Publishing;receptor;Reporting;Research;response;restraint;Role;Signal Pathway;Signal Transduction;Solid Neoplasm;Stomach;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-cell inflamed;T-Lymphocyte;Testing;Therapeutic;Tissues;Transplantation;treatment duration;treatment response;tumor;Tumor Antigens;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: The large double stranded DNA viruses, including herpesviruses and many bacteriophages which are directly responsible for antibiotic drug resistance, bacterial evolution and the ecology of the human microbiome, package their DNA into a capsid shell using a terminase enzyme. We propose studies designed to probe the essential features of genome packaging in these viruses, many of which play major roles in human health, morbidity and mortality. The results of this research will provide a better understanding of virus development a may reveal new targets for novel anti-viral therapeutics.

PI_NAMEs: CATALANO, CARLOS ENRIQUE (contact);MORAIS, MARC ;SMITH, DOUGLAS E

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Anti-viral Agents;Antibiotic Resistance;Bacteriophages;Binding;Biochemical;Biological Assay;Biology;Biophysics;Capsid;Cellular biology;Complex;Dissection;DNA;DNA Packaging;Double Stranded DNA Virus;Ecology;Enzymes;Evolution;Genome;Health;Herpesviridae;Human;Human Microbiome;Individual;Length;Molecular;Morbidity - disease rate;mortality;Motor;novel;nuclease;Nucleocapsid;Nucleoproteins;Pathway interactions;Play;Process;Proteins;Research;Research Design;Role;single molecule;Site;Structure;System;terminase;Viral Genome;virology;Virus;Virus Assembly;virus development

PROJECT_TITLE: Structure and Function of Essential Nucleoprotein Complexes Along a Viral Genome Packaging Pathway

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The present lack of diversity among addiction researchers presents a range of opportunity costs, from hindered scientific innovation to persistent disparities in treatment outcomes. The Training in Research Undergraduate Experience through the Rutgers Addiction Research Center (TRUE RARC) Scholar Program serves to upskill and diversify the next generation of addiction scientists at the undergraduate level via interdisciplinary coursework, lab internships, and career readiness activities to promote a more diverse addiction research field.

PI_NAMEs: DICK, DANIELLE M (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, YOHANSA

PROJECT_TERMS: addiction;Adolescent;Advocacy;Biotechnology;Brain;career;Career Choice;career development;career preparation;Clinical;cognitive development;cohort;Collaborations;Competence;Course Content;course sequence;Data;Data Science;Development;digital;Disparity;Education Projects;education research;Educational process of instructing;Educational workshop;Eligibility Determination;Enrollment;Ensure;Environment;ethnic diversity;Event;experience;Faculty;Foundations;Funding;Future;Genetic;Goals;graduate school;graduate school preparation;Health;Health Professional;Healthcare;Home;improved;Industry;innovation;Internships;Knowledge;Leadership;Learning;Low income;Manuscripts;matriculation;Measures;Mentors;Methods;Minority-Serving Institution;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Neurosciences;New Brunswick;New Jersey;next generation;online repository;opportunity cost;Outcome;Population;Population Heterogeneity;professor;programs;Provider;racial diversity;Recording of previous events;Recovery;Research;Research Personnel;Research Training;Resources;Rewards;Scholars Program;Schools;Science;Scientist;Self Efficacy;Series;Services;skills;social;Social Mobility;statistics;student mentoring;Student Selections;Students;substance use;substance use treatment;symposium;Training;Training Programs;treatment disparity;Treatment outcome;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;Writing

PROJECT_TITLE: Training in Research Undergraduate Experience through the Rutgers Addiction Research Center: The TRUE RARC Scholar Program

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


PHR: Project Narrative The overarching goal of the supplement research is to obtain a detailed understanding of the role of oxidative stress in astrogliosis. The aims of the supplement address redox modifications of glial fibrillary acidic protein (GFAP) and vimentin after endogenous GFAP deletion. The studies can provide mechanistic insights regarding epilepsy-associated astrogliosis.

PI_NAMEs: PATEL, MANISHA N (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Antioxidants;Astrocytes;astrogliosis;comorbidity;Cysteine;Epilepsy;Genetic Transcription;Glial Fibrillary Acidic Protein;Goals;In Vitro;insight;Mediator;Mitochondria;mitochondrial dysfunction;Modification;mRNA Expression;Mus;Nervous System Disorder;neuroinflammation;Neurons;Oxidation-Reduction;Oxidative Stress;parent grant;Prosencephalon;protein expression;Proteins;Rattus;Research;Role;Seizures;SOD2 gene;Testing;Up-Regulation;Vimentin

PROJECT_TITLE: Mitochondrial Mechanisms of Astrogliosis in Epilesy


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: LEAFLABS, LLC

PHR: PROJECT NARRATIVE Electrophysiological recording systems allow direct observation of neural activity in animal subjects. This facilitates the study of crucial neuroscientific topics such as development, learning and memory, and cognition, as well as brain diseases such as Alzheimer’s, epilepsy, Parkinson’s, and depression. LeafLabs’ tools for performing high-channel count electrophysiology experiments in freely-moving rodents will allow researchers to collect and interpret neural data at a large scale, with few experimental constraints to environment complexity or the types of naturalistic behaviors studied.

PI_NAMEs: SHERWOOD, JOHN L (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Address;Alzheimer's Disease;analog;Animal Behavior;Animals;Behavior;Behavioral;behavioral study;Brain;Brain Diseases;BRAIN initiative;Cells;Cognition;Complex;cost;Custom;Data;design;Development;digital;driving force;effective therapy;Electrodes;Electrophysiology (science);Environment;Epilepsy;experimental study;Goals;in vivo;Individual;Learning;light weight;Mammals;Memory;Mental Depression;millisecond;neural;neural circuit;Neurobiology;Neurofibrillary Tangles;Neurologic;neuronal circuitry;Neurons;novel;Parkinson Disease;Population;Research Personnel;Resolution;Rodent;Sampling;Scientific Inquiry;Silicon;Sorting;Surface;System;Techniques;theories;Thinness;Time;tool;Weight;Willow

PROJECT_TITLE: Untethered high channel count electrophysiology for freely-moving animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(13)-B]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative  ATP1A3-related disorders are a group of rare genetic conditions caused by mutations in the brain ion pump gene ATP1A3. They are associated with various devastating neurological manifestations, including intermittent paralysis or abnormal posture of the limbs, loss of balance, epilepsy and cognitive impairment, and there is no effective treatment. In this project, we aim to perform the first systematic clinical study of this condition in Brazil and devise new treatment based on RNA therapeutics in this population, which will also benefit many other patients worldwide.

PI_NAMEs: MOCHIDA, GANESHWARAN HITOSHI (contact);YU, TIMOTHY WEI-WEN

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Affect;Alleles;alternating hemiplegia;American;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Area;ATP1A3 gene;Benign;biomarker identification;Brain;Brazil;Catalogs;Catalytic Domain;Cerebellar Ataxia;Childhood;Clinical;Clinical Research;clinical trial readiness;Clinical Trials;cohort;Collaborations;Complex;Country;Data;Data Collection;data harmonization;Databases;Development;Dimensions;Disease;disease natural history;Disparate;Drug Targeting;Dystonia 12;effective therapy;Enrollment;Epilepsy;Equilibrium;Europe;exome;exome sequencing;Future;gain of function;General Hospitals;Generations;Genetic;Genetic Databases;Genetic Diseases;Genetic Polymorphism;Genotype;Geography;Goals;Hospitals;Impaired cognition;in silico;in vitro Model;Individual;induced pluripotent stem cell;innovation;insight;Ion Pumps;K ATPase;knock-down;Laboratories;Latin America;Limb structure;Link;Literature;low and middle-income countries;Massachusetts;Medical;Membrane;Messenger RNA;Missense Mutation;Modality;molecular sequence database;Morbidity - disease rate;mortality;mutant;Mutation;Natural History;Nervous System Disorder;Neurologic;Neurologic Symptoms;Neuronal Differentiation;Neurons;novel;novel therapeutic intervention;novel therapeutics;oligonucleotide therapeutics;Oligonucleotides;Optic Atrophy;Paralysed;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;patient population;Patients;Phenotype;Physician Executives;Population;Posture;precision medicine;Prevalence;prevent;Pump;Rare Diseases;Reporting;Research;Research Personnel;Research Subjects;Sensorineural Hearing Loss;Single Nucleotide Polymorphism;Source;Talipes cavus;Target Populations;Therapeutic;therapeutic development;therapeutic RNA;therapy development;Time;Universities;Variant

PROJECT_TITLE: ATP1A3-Related Disorders in Brazil: Natural History and Antisense Oligonucleotide Therapy Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Patient Safety;Physical Activity;Rehabilitation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Narrative Older surgical patients are at extremely high risk for cognitive and functional decline after hospitalization, and the COPE-iOS study is examining whether a comprehensive program of computerized cognitive training, guided progressive physical exercise, and health education performed throughout the entire perioperative period will improve long-term cognitive and disability outcomes in elderly surgical patients compared to active attention control. Multiple additional factors, including group social support which is provided in the COPE-iOS study, may influence postoperative recovery. The Investigating Functional Outcomes and Cognition thrU Surgery (InFOCUS) study is a prospective observational cohort measuring cognitive and physical outcomes after major surgery in older adults who are receiving usual care to allow better understanding of the efficacy of the combined cognitive and physical exercise program and further knowledge on potential contributions of enhanced systemic support around major surgery.

PI_NAMEs: HUGHES, CHRISTOPHER  (contact);RENGEL, KIMBERLY F

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Activities of Daily Living;Acute;Administrative Supplement;Aerobic Exercise;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;arm;attentional control;Biological Markers;Cognition;Cognitive;cognitive training;cohort;computer game;computerized;Data;Dementia;design;disability;Disability outcome;Educational Intervention;efficacy evaluation;Elderly;empowerment;Enrollment;exercise program;Exhibits;Feedback;frailty;functional decline;functional disability;functional outcomes;functional status;Habilitation;Health education;high risk;Hospitalization;Human Resources;Impaired cognition;improved;improved outcome;Individual;Injury;inpatient surgery;Intervention;intervention program;Knowledge;Lead;Life;Measures;Medical;Mental Depression;Mental Health;neuroimaging;older adult;Older Population;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patients;peer;Performance;Perioperative;Perioperative Care;Physical Exercise;Physical Function;Plasma;Population;Postoperative Period;postoperative recovery;preservation;Process;programs;prospective;Provider;Public Health;Quality of life;Randomized;randomized trial;Rehabilitation therapy;social group;Social support;Stress;stressor;Stretching;success;Support Groups;surgical risk;Survivors;Telephone;Testing;Text Messaging;Time;Training;treatment as usual;two-arm study;video session

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Prevention

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Nasopharyngeal carcinoma (NPC) accounts for more than 133,000 cancer cases per year worldwide. The association to Epstein-Barr virus (EBV) infection in the tumor is unanimous (~100%) in NPC-endemic areas, and high (90%) in non-endemic areas such as the U.S. This proposal seeks to define the test performance of a prototypic serology assay and to develop a refined high-throughput EBNA1 IgA assay for NPC risk prediction.

PI_NAMEs: SHAIR, KATHY  (contact)

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Adult;Antibodies;Area;Biological Assay;Biological Markers;biomarker panel;cancer risk;case control;Case/Control Studies;China;Chinese;Chronic;Clinical;clinical diagnosis;co-infection;cohort;Communities;cross reactivity;Custom;Data;detection test;Diagnosis;Diagnostic;Diagnostic tests;Disease;DNA sequencing;Early Diagnosis;early screening;Endoscopy;Epitopes;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Escherichia coli;Excision;follow-up;General Population;Goals;Guidelines;high risk population;high throughput screening;Human Herpesvirus 4;Immigrant;Immunodominant Epitopes;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Incidence;Individual;Learning;Libraries;liquid biopsy;Magnetic Resonance Imaging;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Methods;Monitor;mucosal site;Mucous Membrane;Nasopharyngeal Neoplasms;Nasopharynx Carcinoma;neoplastic cell;next generation sequencing;Open Reading Frames;Participant;patient stratification;performance tests;Periodicals;Plasma Cells;Population;predictive test;Prognosis;prospective;Prospective cohort;protein purification;Proteins;Proteome;prototype;Pyroxylin;Recommendation;Reporting;Risk;Risk Assessment;risk prediction;risk stratification;risk variant;Sampling;screening;screening program;Sensitivity and Specificity;Sentinel;Sequence Deletion;seroconversion;Serology;Serology test;Serum;Signal Transduction;Singapore;southeast Asian;Specificity;Spottings;success;Surveys;synthetic peptide;System;Testing;Time;time interval;tumor;tv watching;Validation;Variant;viral DNA;Viral Proteins;Western Blotting;Work

PROJECT_TITLE: Epstein-Barr virus EBNA1 IgA as a biomarker in nasopharyngeal carcinoma risk prediction

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


PHR: PROJECT NARRATIVE The proposed project is relevant to public health as it will develop new AAV-based tools to target specific neuronal populations of excitatory and inhibitory neurons with increased fidelity. These tools will speed up basic science, preclinical research, and aid gene therapy approaches for patients suffering from psychiatric disease and neurological disorders.

PI_NAMEs: BYGRAVE, ALEXEI MANSFIELD (contact);LING, JONATHAN

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: activation-induced cytidine deaminase;adenovirus mediated delivery;Age;Alternative Splicing;Amygdaloid structure;Animals;Basic Science;Brain;Brain region;Breeding;calmodulin-dependent protein kinase II;cell type;Cells;combinatorial;Communities;confocal imaging;Consumption;Cre driver;Data;Data Set;Dependovirus;design;Development;Disease;Enhancers;Enzymes;Event;excitatory neuron;Exons;experimental study;Extravasation;Fluorescence-Activated Cell Sorting;Foundations;Frameshift Mutation;Future;Gene Expression;gene therapy;gene-targeted therapy;Genetic;Genetic Enhancement;Genetic Recombination;Goals;Hippocampus;Hybrids;improved;In Vitro;in vivo evaluation;Individual;inhibitory neuron;Injections;innovation;Interneurons;Knock-in;Label;Length;Link;machine learning algorithm;Maps;Mental disorders;Methods;miniaturize;Mus;Nervous System;Nervous System Disorder;Neurons;Neurosciences;novel;Organism;Parvalbumins;Patients;Pattern;Population;pre-clinical research;promoter;Public Health;Publishing;recombinase;Reporter;Research;Research Personnel;Research Project Grants;RiboTag;RNA;RNA purification;RNA Splicing;Sampling;single-cell RNA sequencing;Specificity;Speed;System;Technology;Testing;Thalamic structure;Therapeutic Intervention;Time;tool;transcriptome sequencing;Transgenic Animals;Transgenic Organisms;Translations;Variant;vector;Viral Packaging;Viral Vector;Work

PROJECT_TITLE: Enhanced Genetic Targeting of Specific Neuronal Populations Using a Minipromoter and Splicing Hybrid Approach

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The object of this proposal is to develop a local cancer immunotherapy to deliver a safe and effective particle- anchored cytokine as a novel combination regimen for eliciting anti-tumor immunity in solid tumors. This project will also explore the impact of this local cancer immunotherapy on the tumor microenvironment in order to decipher the underlying mechanisms. The success of this project will provide a new and effective treatment option to potentiate immunotherapy while also ameliorating systemic toxicity, advance the research of drug delivery technology, and improve our understanding of how the combined localized immunotherapeutics impact the tumor immune infiltrations that boost anti-tumor efficacy.

PI_NAMEs: TONG, RONG  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Adverse effects;Affect;anti-tumor immune response;Antibodies;Binding;cancer immunotherapy;Characteristics;Chemicals;Circulation;clinical application;clinical translation;cytokine;design;Diameter;Distant;Dose Limiting;Drug Delivery Systems;effective therapy;Engineering;Exhibits;Extravasation;Face;Formulation;Immune;immune checkpoint;immune checkpoint blockade;immune-related adverse events;Immunity;immunogenic;immunogenicity;Immunologic Memory;Immunotherapeutic agent;Immunotherapy;improved;Injections;insight;Interleukin-12;Interleukin-15;Lesion;Liposomes;local drug delivery;Localized Malignant Neoplasm;meter;Methodology;Methods;Modality;Modeling;Modification;Molecular;Mus;neoplastic cell;new combination therapies;novel;novel therapeutic intervention;particle;Particle Size;Patients;Peptides;preclinical study;Regimen;Research;scale up;Solid Neoplasm;success;Surface;System;systemic toxicity;Technology;Testing;therapy outcome;Toxic effect;Treatment outcome;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Local Administration of Particle-Anchored Cytokines as a Safe and Effective Cancer Immunotherapy

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Rare Diseases;Regenerative Medicine;Stomach Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Gastric ulcer is characterized by full thickness mucosal injury with a cavity surrounded by acute and chronic inflammation, which is a major cause of gastrointestinal surgery with high morbidity and mortality. Our identification of reprogramming of acid secreting parietal cells into other cell types during gastric ulcer repair has led to the design of present studies that will validate the function of parietal cells as reserve stem cells in gastric ulcer healing and dissect the role of Sox4 in the process. The results of this study will enlighten the molecular mechanism of parietal cell plasticity and its role in gastric ulcer healing, and lead to the discovery of novel targets for treatment.

PI_NAMEs: HUH, WON JAE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acids;Acute;Apoptosis;Atrophic Gastritis;Award;Biological Assay;Cell Differentiation process;Cell Maintenance;cell type;Cells;Chief Cell;Chronic;Complement;Data;design;Development;Dysplasia;effective therapy;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;epithelium regeneration;Fluorescence-Activated Cell Sorting;Foundations;Funding;Future;Gastric Adenocarcinoma;Gastric mucosa;Gastric Parietal Cells;gastric tumorigenesis;Gastric ulcer;Gastrointestinal Surgical Procedures;Genes;Goals;Grant;healing;Helicobacter Infections;Hypertrophic Gastritis;Immunofluorescence Microscopy;Inflammation;Injury;injury and repair;Knock-out;Knowledge;Label;Lesion;Location;Metaplasia;Microscopic;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Muscularis Mucosa;mutant;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;neoplastic;Non-Steroidal Anti-Inflammatory Agents;novel;Oncogenic;Organoids;overexpression;Play;premalignant;prevent;Process;programs;Proteins;Receptor Signaling;repaired;Reporting;Research;Reserve Stem Cell;response;Role;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Sorting;SOX4 gene;spasmolytic polypeptide;stem cells;stemness;Stomach;Testing;therapy development;Thick;transcriptomics;transdifferentiation;Transfection;tumor progression;tumorigenesis;Ulcer;United States

PROJECT_TITLE: Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Fusion-positive alveolar rhabdomyosarcoma (FP-RMS or ARMS) is one the most fatal cancers of childhood. While the disease is still poorly understood, a fusion protein called PAX3-FOXO1 (i.e., PAX3::FOXO1, P3F) is a critical driver of ARMS and dysregulates the expression of many disease genes. The PAX3-FOXO1 fusion protein was discovered three decades ago, yet it has not been successfully targeted for treating FP-RMS. Our comprehensive, coordinated discovery approach will identify small molecules that impact PAX3-FOXO1 activity, exploring multiple mechanisms of action and accelerating the development of agents to treat this cancer of unmet need.

PI_NAMEs: BURGIN, ALEX B;GOULD, ALEXANDRA E;KOEHLER, ANGELA NICOLE (contact);LINARDIC, CORINNE MARY;NOMURA, DANIEL

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acceleration;Affinity;Alveolar Rhabdomyosarcoma;Automobile Driving;Binding;Biochemical;Biological Assay;Biology;Biophysics;Cell Survival;Cells;Cellular Assay;Chemical Agents;Chemicals;Chemistry;chemoproteomics;Childhood;Chimeric Proteins;Chromatin;Chromosomal translocation;Classification;clinical care;Clinical Trials;Complex;Development;Diagnosis;Disease;drug development;drug discovery;Enhancers;Europe;Evaluation;experience;FOXO1A gene;Fusion Oncogene Proteins;Gene Expression;Genes;Genetic Transcription;Glues;Goals;high risk;high throughput screening;Histology;In Vitro;in vivo;Incidence;inhibitor;innovation;Knowledge;Lead;lead candidate;Ligands;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medicine;Mesenchymal Cell Neoplasm;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;Mutation;New Zealand;next generation;Nomenclature;North America;novel therapeutics;Oncogenic;Pattern;PAX3 gene;Pharmaceutical Chemistry;pharmacologic;Pharmacology;Physicians;Precision therapeutics;preclinical evaluation;preclinical study;programs;Protac;protein complex;Proteins;Proteomics;Recurrence;Reporter;Research;research clinical testing;Research Project Grants;Scientist;Skeletal Muscle;small molecule;Structure;System;therapy development;Transcript;transcription factor;Transcriptional Regulation;tumor;tumorigenesis;Ubiquitin

PROJECT_TITLE: Chemical Approaches to Modulate PAX3-FOXO1 in Fusion-Positive Alveolar Rhabdomyosarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M2)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative We do not yet understand why animals behave the way they do, why the same sensory input (e.g., a smell or a sound) can elicit vastly different behaviors across individuals. To study how animals interpret sensory information and turn this information into decisions for survival, we examine a simple creature –a fly larva– as it performs one of the most important survival tasks: finding a food source. By quantifying, modeling, and then controlling the nervous system of a larva while it converts information from an ambiguous world into accurate navigational decisions, we aim to reveal the inner workings of a simple yet remarkably powerful brain and build new theories of how our own brain works.

PI_NAMEs: LOUIS, MATTHIEU R. P. J. C. G. (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Anatomy;Animals;Architecture;Atmosphere;Behavior;behavior prediction;Behavioral;behavioral response;behavioral tolerance;Brain;Cell model;Chemotaxis;Computer Models;Cues;Data;data-driven model;Decision Making;Detection;Diffusion;Drosophila melanogaster;dynamic system;Electrons;Electrophysiology (science);Elements;Environment;Esthesia;experimental study;fly;Food;Goals;Heart;improved;Individual;Larva;larval control;light microscopy;Maps;Measures;Methods;Microfluidics;Modality;model organism;Modeling;Motor;Movement;Nervous System;Nervous System control;neural;neural circuit;neural model;neuroimaging;neuromechanism;Neurons;Noise;Odors;Olfactory Pathways;olfactory sensory neurons;olfactory stimulus;optogenetics;Organism;Output;Partner in relationship;Pathway interactions;Pattern;Peripheral;Play;Postbaccalaureate;predictive modeling;Process;Resolution;response;Role;Running;Sensory;sensory input;Series;Signal Transduction;Smell Perception;sound;Source;Speed;Stimulus;System;Systems Theory;Testing;theories;Time;tool;Toxin;Training;Validation;virtual;virtual reality;Work

PROJECT_TITLE: Building a Complete, Predictive, Data-Driven Model of Action Selection During Olfactory Navigation: Diversity Supplement for Postbaccalaureate Training