ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The rate of nurses who die by suicide has reached alarming proportions, with some estimates higher than the general population and other similar workforces. However, there is limited evidence about individual and environmental factors that predispose a nurse to suicidal behavior in real-world clinical settings, nor are there significant investigations of the interplay between those factors and physiologic stress responses or epigenetics. This project will leverage advancements in stress measurement (hair cortisol) and epigenetic analysis (DNA methylation) to investigate which factors increase suicidal behavior in nurses, which may help to better identify high-risk individuals and to inform suicidal behavior prevention interventions.

PI_NAMEs: NORFUL, ALLISON ANDRENO (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Academy;Age;Alleles;Autopsy;Biological;biological adaptation to stress;Biological Markers;Blood;Cessation of life;Characteristics;Chronic stress;Clinical;Corwin;Cross-Sectional Studies;Data;Data Analyses;Decision Making;demographics;Development;Discipline of Nursing;Discrimination;Disease susceptibility;Diurnal Rhythm;Divorce;DNA Methylation;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;experience;Exposure to;Feeling suicidal;Funding;Gambling;Gender;General Population;Genes;Genetic;Genetic Risk;genome-wide;Goals;Grant;Growth;Hair;Health;Healthcare;high risk;high risk population;Household;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Income;Individual;instrument;Investigation;Iowa;Lateral;Life;lifestyle factors;Link;longitudinal analysis;longitudinal design;Longitudinal Studies;loved ones;Marital Status;Measurement;Measures;Mediating;Medicine;Mentors;Mentorship;Methylation;Modeling;Moods;Nurses;Occupational;Patient Self-Report;perceived stress;Pharmaceutical Preparations;Physician-Nurse Relations;Physicians;Physiological;power analysis;Precipitating Factors;Predisposing Factor;preventive intervention;Production;professional atmosphere;programs;protective factors;Psychiatric Diagnosis;Psychological Interview;Psychopathology;Public Health;Race;recruit;Reporting;Research;response;Risk Factors;Saliva;Sample Size;Series;Serum;sex;shift work;Sleep;sleep health;Smoking;Smoking History;social cognition;Statistical Models;Stress;stress reactivity;Stressful Event;stressor;study characteristics;substance use;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Surveys;Testing;Time;Training;Training Programs;Trauma;United States;Violence;Work;Workload

PROJECT_TITLE: Physiologic Stress and Epigenetic Mechanisms that Precipitate Risk for Suicidal Behavior in Nurses

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE Disorders of the musculoskeletal system with advancing age or due to injury and trauma are among the most debilitating to the human body and costly to the healthcare system with disability. Novel treatments will require convergence of molecular, cellular, and organismic research through interdisciplinary integration of biomedical science and engineering. This T32 Program is based on the unique concept of training Ph.D. candidates in the realm of scientific convergence applied to the field of regenerative engineering to enable these discoveries.

PI_NAMEs: LAURENCIN, CATO T. (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training Program


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE This study will measure individual- and environmental-level race-specific stressors and identify the biologic mechanisms linking them to late-life cognitive decline and risk of Alzheimer’s dementia in older Black adults. These data are critical to reduce disparities and the burden of dementia and cognitive decline in a rapidly growing and understudied population.

PI_NAMEs: BARNES, LISA L (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Address;Adult;African American;Aging;aging population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Arterioloscleroses;Atherosclerosis;Autopsy;Awareness;Behavior;Biological;Black Populations;Black race;Blood;Blood Vessels;Brain;brain health;Brain Pathology;brain tissue;Cardiovascular Diseases;Cerebral Amyloid Angiopathy;cerebrovascular;Chronic;Clinical;Cognition;Cognitive;cohort;Cohort Studies;Coupled;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;Dementia;dementia burden;dementia risk;density;Discrimination;Disease;Disparity;disparity reduction;Education;Epidemiology;Ethnic Population;follow-up;Funding;Goals;Health;health care availability;health care service utilization;health disparity;hospitalization rates;Impaired cognition;Individual;Inequity;Infarction;Inflammation;Inflammatory;Intervention;Investigation;Knowledge;late life;Lead;Link;Lived experience;Measures;Medicare claim;Memory;Mental Health;Microglia;Minority;Neighborhoods;Neurobiology;neuropathology;novel;Older Population;pandemic disease;Participant;Pathologic;Pathology;Pathway interactions;Pattern;Persons;Physical activity;physical conditioning;Plasma;Policies;poor health outcome;Population;Prevention;Proteins;Proteomics;Protocols documentation;Psychological Impact;public health priorities;Race;racial difference;racial disparity;racial population;Reproducibility;Research;research study;residential segregation;Resources;Risk Factors;Sample Size;Social Impacts;social vulnerability;Societies;socioeconomics;Source;Stress;stressor;Structural Racism;System;Testing;Therapeutic;vascular risk factor;Violence

PROJECT_TITLE: Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Macrophages in the joint synovium are key to maintaining homeostasis, but their dysregulation in aging contributes to the development of arthritis. We propose to use genomic approaches to understand how the aging environment alters synovial macrophages on the molecular level. By using mouse models of aging, we aim to identify specific regulators that will provide a target for future therapies.

PI_NAMEs: WINTER, DEBORAH RACHELLE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adopted;Age;age related;age related changes;age related decline;age-related disease;aged;Aging;ankle joint;Arthritis;ATAC-seq;Bone Marrow;cell type;Cells;Chimera organism;ChIP-seq;Chromatin;computer framework;Data;Degenerative polyarthritis;Development;Disease;Downstream Enhancer;drivers of aging;Enhancers;Environment;epigenomic profiling;epigenomics;Exhibits;Functional disorder;functional genomics;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Genomic approach;Genomics;Goals;Health;Heterogeneity;Homeostasis;Human;Immune;Immune system;Immunity;improved;Intervention;Joints;Lead;Link;Macrophage;Modeling;Molecular;monocyte;mouse model;Mus;Myelogenous;old mice;Patients;Pattern;Phenotype;Population;Predisposition;Prevention strategy;Process;Publishing;receptor;Regulation;Regulatory Element;residence;Role;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Synovial Membrane;systemic inflammatory response;Testing;therapeutic target;Time;Tissue-Specific Gene Expression;Tissues;TNF gene;transcription factor;transcriptome sequencing;Translating;Transplantation;Tumor Necrosis Factor Receptor;Wild Type Mouse;Work

PROJECT_TITLE: Transcriptional Regulators in Aging Macrophages

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE Chromosomal instability (CIN) is a feature of aggressive human cancers; yet how it promotes cancer progression remains poorly understood. Building on our preliminary findings, we will ask whether CIN drives cancer spread by shaping the interaction between cancer cells and immune cells to promote immune escape. We also apply a computational method that detects cell-cell interactions to probe whether the findings from our experimental models can be generalized to a variety of human cancers.

PI_NAMEs: BLENIS, JOHN ;LAUGHNEY, ASHLEY MARIE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Aneuploidy;Anti-Inflammatory Agents;Apolipoprotein E;ATF6 gene;Benchmarking;Biological;biological adaptation to stress;Biological Response Modifiers;Breast Cancer Model;Bypass;cancer cell;cancer type;case control;Cell Communication;cell type;Cells;Chromosomal Instability;Chromosomal Loss;Chromosome abnormality;chromosome missegregation;Chromosome Segregation;Chromosomes;Chronic;Colorectal Cancer;Complex;computerized tools;Computing Methodologies;Coupling;cytokine;Cytosol;Data;data modeling;Data Set;Dependence;desensitization;detection method;Development;Disease Progression;Drug resistance;ds-DNA;Ecosystem;endoplasmic reticulum stress;Equilibrium;Event;Exhibits;Experimental Models;gene regulatory network;Genes;Genetic;Genetic Epistasis;genetic manipulation;Genetic Transcription;Genomics;Goals;granulocyte;Heterogeneity;Human;human data;Immune;Immune Evasion;Immune system;Immunocompetent;Immunosuppression;improved;in silico;Infiltration;innate immune pathways;innovation;Interferon Type I;Interferons;Knowledge;KRASG12D;Ligands;LoxP-flanked allele;Lung;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Methods;micronucleus;Modeling;Molecular;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel strategies;Nuclear Envelope;Pancreas;paracrine;Phenotype;Physiological;Process;programs;receptor;Recurrence;response;Role;Rupture;Sampling;sensor;Shapes;Signal Transduction;single-cell RNA sequencing;Source;Stimulator of Interferon Genes;Stress Tests;System;T-Lymphocyte;Tachyphylaxis;Technology;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;therapy resistant;tool;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-Derived;Work

PROJECT_TITLE: Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE New vessel formation is critical for proper embryonic development and pathological progression of many diseases. We identified Myct1 (Myc target 1) as a novel and crucial endothelial gene required for tumor angiogenesis and tumor growth. Unexpectedly, Myct1 deficiency in endothelial cells leads to enhanced anti- tumor immunity, suggesting that Myct1 can modulate endothelial cell remodeling of the tumor immunity. The overall goal of the proposed studies is to investigate the mechanisms by which Myct1 regulates angiogenesis and tumor immunity and develop novel therapeutic modalities against Myct1 for treating cancer or related patho-angiogenic diseases.

PI_NAMEs: CHOI, KYUNGHEE  (contact);PARK, CHANGWON

PROJECT_TERMS: Address;Adherens Junction;Adhesions;angiogenesis;Angiogenesis Inhibitors;anti-PD-1;anti-PD1 antibodies;Antibodies;Apoptosis;Binding Proteins;Blood;Blood Vessels;Cancer Control;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CDH5 gene;Cell Adhesion;Cell Adhesion Molecules;Cell membrane;cell motility;Cells;Cellular biology;comparison control;Complex;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Defect;Disease;effective therapy;efficacy evaluation;Embryonic Development;Endothelial Cells;Endothelium;Genes;Genetic;Goals;High Endothelial Venule;Human;Hypoxia;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;improved;Investigation;KDR gene;knock-down;Knock-out;Knockout Mice;Link;Macrophage;Malignant Neoplasms;member;Membrane Proteins;migration;Modality;Molecular;Monoclonal Antibodies;Mus;novel;novel therapeutics;Outcome;Output;overexpression;Pathologic;Pathway interactions;Perfusion;Permeability;Phase;Phosphorylation;Play;programmed cell death protein 1;Property;Proteins;Proteomics;recruit;Regulation;Reporting;rho GTP-Binding Proteins;Role;single-cell RNA sequencing;Small Interfering RNA;Solid Neoplasm;Structure;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Tight Junctions;Tissues;translational potential;treatment strategy;tumor;Tumor Angiogenesis;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Myct1 control of the angioimmune interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(80)S]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia; however, the molecular mechanisms underlying sodium sensing are poorly understood. The purpose of this translational project is to identify key sodium-sensing regions of the brain and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation and salt sensitive hypertension, which has public health implications.

PI_NAMEs: STOCKER, SEAN D;WENNER, MEGAN M (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acute;Adult;Age;Animal Model;Animals;antagonist;Attenuated;Blood;Blood - brain barrier anatomy;Blood Pressure;blood pressure regulation;Blood Vessels;Brain;Brain region;Cardiovascular Diseases;Cells;Cerebrospinal Fluid;Chronic;Collaborations;cost;Dahl Salt-Resistant Rats;Data;Development;Elements;Excess Dietary Salt;experimental study;extracellular;Functional Magnetic Resonance Imaging;Furosemide;Goals;high salt diet;Homeostasis;Human;human model;human subject;Hypernatremia;Hypertension;Hypothalamic structure;Impairment;In Vitro;in vivo;Infusion procedures;Ingestion;Interruption;Intravenous infusion procedures;Kidney;Laboratories;Lesion;Mediating;Modeling;Molecular;Nerve;neural;Neural Pathways;Neurons;neurotransmission;novel;novel therapeutic intervention;novel therapeutics;optogenetics;Organ;organum vasculosum of the lamina terminalis;patch clamp;Pathogenesis;Pathway interactions;Peripheral Resistance;pharmacologic;Plasma;Population;prevent;Prosencephalon;Protein Isoforms;Public Health;Rattus;Regulation;Resistance;response;Rest;Rodent;Rodent Model;salt intake;salt sensitive;salt sensitive hypertension;sensor;sex;Sodium;Sodium Chloride;Subfornical Organ;symporter;System;Techniques;Testing;Thirst;transcriptomics;Vasopressins;Water

PROJECT_TITLE: Forebrain electroneutral transporters in salt-sensitive hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Scleroderma;Transplantation;Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE Fibrosis is a common final outcome of inflammatory diseases that results in excess collagen and other extracellular matrix proteins in tissue. This proposal uses mouse models to elucidate how chronic epidermal growth factor receptor activation drives fibrosis in the skin and its relationship with interferon signaling. By understanding how this receptor tyrosine kinase drives the production of matrix proteins, we will be able to develop new therapies that target these processes to help improve patients' lives.

PI_NAMEs: ODELL, IAN D (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Affect;Autoimmune Diseases;Binding Proteins;Biological Models;Biological Process;Bleomycin;Blood Vessels;Bone Marrow;cell type;Cells;Cessation of life;Chimera organism;Chronic;chronic graft versus host disease;chronic inflammatory disease;Chronic Phase;Co-Immunoprecipitations;Collagen;Complex;conditional knockout;Development;Diabetes Mellitus;Disease;Doxycycline;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epiregulin;Excision;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fc Receptor;Fibroblasts;Fibrosis;Functional disorder;Future;Gefitinib;Gene Expression;Genes;Goals;graft vs host disease;Heart;Hematopoietic;Hereditary Disease;Histologic;Histology;Human;Immune;Immune system;improved;in vivo;Individual;inducible gene expression;Inflammatory;insight;Interferon Receptor;Interferons;Investigation;Kidney;Knockout Mice;Knowledge;Lead;Ligands;Liver;Lung;Maintenance;Mass Spectrum Analysis;Measures;Mesenchymal;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;Obesity;Organ;Outcome;Pathogenesis;Pathway interactions;Patients;Pericytes;Phase;Phenotype;Phosphorylation;Post-Translational Protein Processing;Process;Production;promoter;Proteins;Proteomics;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;response;Scleroderma;Signal Pathway;Signal Transduction;Skin;skin disorder;skin fibrosis;skin organogenesis;small molecule inhibitor;STAT1 gene;Stem cell transplant;System;Techniques;Testing;Time;Tissues;transcription factor;virtual;Wild Type Mouse;Work

PROJECT_TITLE: Epidermal Growth Factor Receptor Signaling in Fibrotic Skin Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The National Dental Practice-Based Research Network is a group of practicing dentists who also conduct dental research. The CHR Coordinating Center, with 25 years of experience coordinating multi-site studies and research networks, is proposing to serve as a coordinating center for the Network. In this role, it would to provide scientific, technical and operational support for developing, implementing and disseminating multi-site dental research studies.

PI_NAMEs: MCBURNIE, MARY ANN  (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Architecture;Clinical;Collaborations;Communication;Concept Review;Data;Data Collection;Data Management Resources;data modeling;Databases;Dental;Dental Care;Dental Care Delivery;Dental General Practice;Dental Research;Dentists;Development;Dissemination and Implementation;effectiveness study;Electronics;Equipment and supply inventories;experience;follow-up;Foundations;Group Practice;health record;implementation process;Institutional Review Boards;Leadership;Link;Medical;Methodology;Multicenter Studies;National Institute of Dental and Craniofacial Research;operation;Oral health;outreach;Patient Recruitments;Policies;Population;practice-based research network;Procedures;Process;Productivity;Provider;Reporting;Research;Research Design;Research Infrastructure;research study;Resources;response;Role;Secure;Site;Solid;Source;Strategic Planning;Surveys;System;Technical Expertise;Technology;tool;Training;trend;web site;Work

PROJECT_TITLE: National Dental Practice-Based Research Network: Coordinating Center


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: CENTER OVERALL: PROJECT NARRATIVE This application seeks to establish the Kansas Center for Metabolism and Obesity Research at the University of Kansas Medical Center. This center will coordinate the activities of existing investigators, develop three new research cores, and mentor the career development of new investigators. It will create the intellectual and physical infrastructure necessary to develop new treatments for obesity, metabolic dysfunction, and obesity related complications.

PI_NAMEs: THYFAULT, JOHN P;WEINMAN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acute Pain;Adolescent;Adult;Affect;Aging;Anxiety;Area;Award;Basic Science;Behavior;Bioenergetics;Bioinformatics;Blood;Body System;Body Weight decreased;career;career development;Cells;Centers of Research Excellence;Chronic Disease;Chronic pain syndrome;Clinical;Clinical Research;Collaborations;combat;Communities;COVID-19;Development;Diabetes Mellitus;Disease;Eating;Education;energy balance;Energy Metabolism;faculty support;fatty liver disease;Foundations;Funding;Future;Goals;Growth;Health;Home;Human;human subject;Hypertension;improved;Incidence;Infection;Infrastructure;Institution;Interdisciplinary Study;Internal Medicine;Isotopes;Kansas;Kidney Diseases;Lead;life span;Link;Liver diseases;Malignant Neoplasms;Measures;Medical center;Mental Depression;Mental disorders;Mentors;Mentorship;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;Mitochondria;Modern 1601-history;multidisciplinary;neuroregulation;Neurosciences;next generation;nutrition;obese patients;Obesity;Obesity associated disease;Obesity Epidemic;obesity prevention;obesity treatment;Outcome;Pathology;Persons;Phase;Physical activity;Physiology;Population;Population Heterogeneity;precision medicine;Predisposition;prevent;Prevention;programs;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Rodent;Rodent Model;Role;rural area;Rural Community;Series;synergism;Talents;Time;Tissues;Translational Research;translational research program;United States National Institutes of Health;Universities;urban area;Weight;Work

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Obesity

PI_NAMEs: WEINMAN, STEVEN A (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Award;career development;Centers of Research Excellence;Cities;Communities;diversity and inclusion;Education;forging;Goals;Infrastructure;Institution;Interdisciplinary Study;Kansas;Knowledge;Leadership;Link;Medical center;meetings;member;Mentors;Mentorship;Metabolic dysfunction;Metabolism;Obesity;Obesity associated disease;obesity prevention;Occupational activity of managing finances;Office of Administrative Management;Phase;Play;Population;Program Development;Program Evaluation;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Scientist;Series;symposium;Universities

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Rural Health

PI_NAMEs: DONNELLY, JOSEPH E. (contact)

PROJECT_TERMS: Accelerometer;Adult;Air;Alzheimer's Disease;Basal metabolic rate;Behavioral;Biological Markers;Body Composition;Body Weight;Body Weight decreased;Brain;Calibration;Centers of Research Excellence;Central Nervous System;Child;Clinical;community setting;comorbidity;Complex;Cost Analysis;data registry;Diet;digital imaging;Dose;Dual-Energy X-Ray Absorptiometry;energy balance;Energy Intake;Energy Metabolism;Equipment;evidence base;Exercise;Exercise Physiology;feeding;Food;Gastrointestinal tract structure;Goals;gut microbiome;Home;Human;human subject;Indirect Calorimetry;Individual;Intake;Intellectual functioning disability;International;Intervention;intervention delivery;invention;Investigation;Kansas;Laboratories;Liver;Location;Macronutrients Nutrition;Magnetic Resonance Imaging;Measurement;Medical center;Metabolic;metabolic abnormality assessment;Metabolism;Micronutrients;Monitor;novel strategies;nutrient absorption;nutrition;Obesity;obesity treatment;Occupations;Overweight;Pancreas;Participant;Patient Self-Report;Peripheral;Physical activity;physically handicapped;Plethysmography;Population;portability;Prevention;Process;programs;Recommendation;Registries;Research;Research Personnel;Research Project Grants;Research Support;rural dwellers;Schools;secondary analysis;sedentary;Services;Special Population;stable isotope;Surveys;Techniques;Time;Training;training opportunity;Underserved Population;United States National Institutes of Health;Universities;wasting;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: GEIGER, PAIGE C (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Behavior;Behavioral;Bioenergetics;Biological Models;Body Composition;Body measure procedure;Carbohydrates;Cell Size;Cells;Cellular Metabolic Process;Chronic;Chronic Disease;Core Facility;Coupling;design;Diet;diet and exercise;Dietary intake;dietary manipulation;Disease;energy balance;Energy Intake;Energy Metabolism;Environmental Risk Factor;Equipment;Exercise;Fasting;Fatty acid glycerol esters;Fatty Acids;Food Intake Regulation;Genus Hippocampus;Glucose;Homeostasis;Human;human model;Impairment;in vivo;Individual;Insulin Resistance;Isotope Labeling;Isotopes;Kansas;Liver;Macronutrients Nutrition;Measurement;Measures;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methodology;Mission;Mitochondria;Mus;Muscle;new therapeutic target;Obesity;Obesity associated disease;obesity development;Outcome Measure;oxidation;Oxygen Consumption;Palmitates;Pancreas;Participant;Pathologic;Physical activity;Play;pre-clinical;Pre-Clinical Model;Predisposition;Rattus;Reactive Oxygen Species;Research;Research Personnel;Resources;Rodent;Rodent Model;Role;Sampling;Scientist;Services;Sleep;System;Temperature;Testing;Thermogenesis;Time;Time-restricted feeding;Tissues;tool;Tracer;translational study;Treatment Protocols;Weight Gain

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Metabolism Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Nutrition;Obesity;Precision Medicine

PI_NAMEs: APTE, UDAYAN  (contact)

PROJECT_TERMS: Address;Adipose tissue;Animal Experiments;Animal Model;Arkansas;Award;Basic Science;Big Data;biobank;Bioinformatics;Biological Assay;Biomedical Research;Biometry;Biostatistics Core;Blood;Cell Culture Techniques;Cells;Cellular Structures;Centers of Research Excellence;Charge;Clinical;Collaborations;Communities;Computing Methodologies;Confusion;Core Facility;Custom;Data Collection;Data Set;Dedications;design;Development;Disease;disease mechanisms study;energy balance;Experimental Models;Face;Flow Cytometry;Funding;Genomics;Goals;Grant;high throughput screening;Human;In Vitro;Infrastructure;Institution;Institutional Review Boards;Investigation;Kansas;Liver;Logistics;Medical;Medical center;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methodology;Methods;multidimensional data;Muscle;Nuts;Obesity;Obesity associated disease;Organ;Pathogenesis;patient population;Patients;Plasma;population based;precision medicine;Process;Proteomics;Research;Research Personnel;Research Project Grants;Research Training;Resources;Rodent;Sampling;Science;Scientist;Serum;Services;skills;Technical Expertise;Techniques;Technology;Testing;Tissue Banks;Tissue Sample;Tissues;Training;transcriptomics;translational pipeline;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Cells, Tissues, Bioanalysis and Biostatistics Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Our proposal aims to develop new strategies to combat a common and aggressive subtype of human breast cancer (triple-negative breast cancer, or TNBC) through modulation of antitumor immune response. We recently discovered that targeting MYC+ TNBC with spliceosome-targeted therapeautics (STTs) triggers a form of viral mimicry, where mis-spliced RNAs trigger a double-stranded RNA antiviral program. Herein, we propose to elucidate the molecular and cellular mechanisms of this STT-induced antiviral signaling and harness the resulting immune response as a therapeutic approach for TNBC.

PI_NAMEs: WESTBROOK, THOMAS  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Affect;Agonist;anti-tumor immune response;Anti-viral Response;Automobile Driving;Biology;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;cancer type;Cell Compartmentation;cell type;Cells;chemical genetics;Chemicals;Clinical;clinical development;cohort;combat;combinatorial;Computational algorithm;Data;Double-Stranded RNA;efficacy testing;Evaluation;FRAP1 gene;Funding;Genetic Screening;Genetic Transcription;Heterogeneity;Human;Hypersensitivity;Immune;immune activation;immune cell infiltrate;immune modulating agents;Immune response;Immune signaling;Immune system;Immunocompetent;immunogenic;Immunologics;Immunomodulators;Impairment;in vivo;Inflammation;Inflammatory;Interferons;Label;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Methods;mimicry;Modeling;Molecular;molecular targeted therapies;mRNA Precursor;Nature;neoplastic cell;Newly Diagnosed;novel;Oncogenic;Pathway interactions;Pattern;PIK3CA gene;pre-clinical;preclinical development;Process;Productivity;Prognosis;programs;Proto-Oncogene Proteins c-myc;Regimen;Regulation;Reporter;Resistance;response;RNA;RNA Splicing;RNA-Binding Proteins;RNA-targeting therapy;Role;sensor;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spliceosomes;Structure;targeted treatment;Therapeutic;therapy resistant;transcriptome;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;Viral;Work

PROJECT_TITLE: Therapeutic Targeting of RNA Splicing in Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because dysfunction of glutamatergic neurotransmission is believed to underlie a number of complex brain disorders including Autism Spectrum Disorder, Schizophrenia and Alzheimer’s Disease. The proposed research is relevant to the mission of the NINDS given that knowledge concerning how glutamatergic synapse function is regulated will aid in the development of new therapeutic strategies for treating such disorders.

PI_NAMEs: HERRING, BRUCE  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 3q29;Affect;Alternative Splicing;Alzheimer's Disease;AMPA Receptors;Animal Behavior;Animals;Antibodies;autism spectrum disorder;Behavior;Behavioral;Binding;Biological;Brain;Brain Diseases;Brain region;Clinical Data;Complex;Cytoplasmic Granules;Data;Dendrites;dentate gyrus;Development;Disease;Distal;DLG1 gene;Electrophysiology (science);Endoscopy;Episodic memory;Etiology;Exhibits;Functional disorder;Gene Expression;Genes;Genetic;genetic regulatory protein;Glutamates;Goals;high risk;hippocampal pyramidal neuron;Hippocampus;Human;Human Genetics;imaging approach;Imaging Device;immunoreactivity;in vivo;in vivo imaging;Individual;information processing;innovation;Knowledge;Label;Laboratories;Lateral;Lead;Link;Medial;Memory;Mental disorders;Methods;microdeletion;Missense Mutation;Mission;Molecular;National Institute of Neurological Disorders and Stroke;Neurons;neurotransmission;novel therapeutic intervention;Pathologic;Pathology;Pathway interactions;Perforant Pathway;Play;pre-clinical;Property;Protein Isoforms;Public Health;Reagent;Regulation;Research;response;Rodent;Rodent Model;Role;Schizophrenia;schizophrenia risk;Severities;Specificity;Symptoms;Synapses;synaptic function;Techniques;Testing;Time;tool;trafficking;transmission process;Variant;Work

PROJECT_TITLE: Uncovering the role of SAP97 in synaptic function and schizophrenia.

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Nutrition;Obesity

PI_NAMEs: MORRIS, E MATTHEW (contact)

PROJECT_TERMS: Acute;Biogenesis;Body Weight;Brain;Cardiovascular Diseases;Cell Nucleus;Chronic;Complex;Consumption;Data;Dependovirus;Diet;Eating;energy balance;Energy Intake;Energy Metabolism;Energy Metabolism Pathway;Environment;Exposure to;Fasting;Fatty acid glycerol esters;fatty acid oxidation;feeding;Feeding behaviors;Food;Food Intake Regulation;food restriction;Gene Expression;Genetic Transcription;ghrelin;Goals;Homeostasis;Hormonal;hormonal signals;Hormones;Hypothalamic structure;improved;Insulin;interest;Kansas;Knock-out;Leptin;Link;lipid metabolism;Lipids;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic rate;Metabolism;Mitochondria;mouse model;mRNA Expression;Mus;neural;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;nrf1 protein;Nutrient;Nutrient availability;Obesity;obesogenic;overexpression;Pathway interactions;Peripheral;Peroxisome Proliferator-Activated Receptors;pharmacologic;Pharmacologic Substance;reduced food intake;Regulation;Research;Research Project Grants;Respiratory physiology;response;Role;Satiation;Seasons;Signal Pathway;Signal Transduction;Stimulus;Structure;Structure of nucleus infundibularis hypothalami;Sucrose;Sum;Testing;Thermogenesis;Time;Tissues;tool;total energy expenditure;Transcriptional Activation;Transcriptional Regulation;Weight Gain

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Project 2


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Neurodegenerative disorders such as dementia with Lewy bodies and Parkinson’s disease are characterized by the a-syn accumulation but the downstream pathophysiological mechanisms are not known. Our data indicate that a-synuclein induces changes in nuclear paraspeckles that regulate gene expression and RNA processing. We propose to use patient-derived neurons and other models to examine mechanisms that lead to changes in gene regulation, which may help to mechanistically explain proteome dysfunction in synucleinopathies.

PI_NAMEs: MAZZULLI, JOSEPH R (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: age related neurodegeneration;alpha synuclein;Axon;axon guidance;Binding;Brain;Buffers;Cell Death;Cell Nucleus;Cells;Cellular Stress;ChIP-seq;Data;Dementia with Lewy Bodies;Detergents;Development;Disease;Enzymes;Event;Exons;Functional disorder;functional restoration;gene correction;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Health;human induced pluripotent stem cells;in vitro Model;in vivo;Inclusion Bodies;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;knock-down;Knock-out;Lewy Bodies;Lewy Body Dementia;Link;Liquid substance;Maintenance;Measures;Mediating;Membrane;Methods;Midbrain structure;Mitochondria;Modeling;Morphology;mouse model;Mutation;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neurons;neurotoxicity;novel;novel therapeutics;Nuclear;Nuclear Proteins;Nuclear RNA;Nucleoplasm;Parkinson Disease;Parkinson's Dementia;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;Phase Transition;Phenotype;Physiological;Play;Predisposition;prevent;prion-like;Process;protein aggregation;protein degradation;protein purification;protein transport;Proteins;Proteome;Proteomics;proteostasis;Regulation;RNA;RNA Editing;RNA Processing;RNA Splicing;RNA-Binding Proteins;RNA-specific adenosine deaminase 3;Role;scaffold;Solubility;Stress;Synapses;synucleinopathy;Therapeutic;trafficking;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translations;Untranslated RNA;Virulence Factors;Work

PROJECT_TITLE: Mechanisms of gene regulation and RNA processing in synucleinopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Chronic pain disorders negative impact over 100 million Americans who suffer with the persistence of nociceptive sensory and negative affective symptoms. Presently available pain treatments fall short in providing safe and effective analgesia and often result in detrimental side effects due to their lack of specificity. This proposal aims to characterize a negative affective brain circuit in healthy and chronic pain states with the aim of informing the development of targeted treatments to alleviate the emotional unpleasantness of pain perception.

PI_NAMEs: WOJICK, JESSICA ANNE (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute;Affect;Affective;Affective Symptoms;American;Amygdaloid structure;Animals;Appetitive Behavior;Automobile Driving;avoidance behavior;awake;Axon;Behavior;Behavioral;Brain;Brain region;Calcium;calcium indicator;career;cell type;Chronic;chronic pain;chronic pain patient;chronic painful condition;Clinical Research;Complement;Corpus striatum structure;Data;Desire for food;Development;Diagnostic Imaging;Diagnostic tests;Emotional;Emotions;experience;Fellowship;Functional disorder;functional group;Future;Glutamates;Goals;Horns;Human;Hyperactivity;Hypersensitivity;Image;Imaging Device;Implant;in vivo calcium imaging;Individual;injured;Injury;Light;Medial;Mentors;Motivation;Mus;negative affect;Negative Valence;neural;neural circuit;neuronal cell body;Neurons;Neuropathy;neuropsychiatric disorder;Neurosciences;neurotransmission;Nociception;Nociceptive Stimulus;Nucleus Accumbens;Operative Surgical Procedures;Opsin;optical fiber;optogenetics;Outcome;Output;Pain;pain chronification;Pain management;pain perception;Pain Research;Pathologic;persistent symptom;Population;preclinical study;Presynaptic Terminals;Process;Research;Resolution;response;Role;Sensory;sensory stimulus;side effect;Specificity;Stimulus;Structure;System;Technical Expertise;Training;transcriptomics;Translational Research;transmission process;Viral;Visualization

PROJECT_TITLE: Functional characterization of an amygdala to accumbens nociceptive circuit


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Obesity;Prevention

PI_NAMEs: STEGER, FELICIA  (contact);THYFAULT, JOHN P

PROJECT_TERMS: Adult;blood glucose regulation;Body Composition;Body Weight Changes;Body Weight decreased;C-Peptide;Caloric Restriction;Cell Physiology;clinically relevant;Continuous Glucose Monitor;Data;Diabetes Mellitus;Eating;Gastric Inhibitory Polypeptide;gastric inhibitory polypeptide receptor;glucagon-like peptide 1;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Group Meetings;Health education;Hour;improved;Individual;Inflammation;Inflammatory Response Pathway;Insulin;insulin secretion;insulin sensitivity;Intermittent fasting;Intervention;Kansas;Life Style;Measures;Metabolic;Metabolism;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome Measure;Patients;Phenotype;predicting response;primary endpoint;programs;Randomized, Controlled Trials;Regimen;remote delivery;Research;response;standard of care;Structure of beta Cell of islet;Testing;Time-restricted feeding

PROJECT_TITLE: Effects of Intermittent Fasting on Glycemic Control in Patients with Diabetes


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Methamphetamine;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative We have entered a new wave of polysynthetic drug use: people are combining drugs in new ways, eg the rising popularity of methamphetamine and heroin/fentanyl, the previously rare “goofball”. We do not know why stimulant-related deaths have risen: is it because of contamination of the stimulant supply eg with fentanyls; intentional co-use, or different, novel methods of polydrug use? The Synthetics in Combination (SYNC) study will examine a) changes in synthetic drug supplies, esp. fentanyls and methamphetamine, b) the effects of these changes on how people use drugs and c) the effects of both changing supply and use patterns on drug- related morbidity and mortality.

PI_NAMEs: CICCARONE, DANIEL H (contact)

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: Accounting;Adverse effects;adverse outcome;Benzodiazepines;Cessation of life;Communities;Data;Databases;design;Drug Combinations;drug market;Drug usage;Drug user;Economics;Environment;Epidemic;epidemiological model;Epidemiology;Ethnography;Fentanyl;fentanyl analog;Health;Heroin;high risk;high risk population;Hospitalization;Illicit Drugs;Injections;innovation;insight;Intervention;Interview;Investments;Knowledge;Marketing;Measures;Methamphetamine;methamphetamine use;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multiple drug use;Naloxone;novel;Opioid;opioid epidemic;opioid overdose;Outcome;Outcome Study;Overdose;overdose death;Pattern;Peer Review;Persons;Pharmaceutical Preparations;Pharmacologic Substance;pill;Play;predictive modeling;preference;prescription opioid;Price;Proliferating;protective factors;Public Health;public health intervention;Research;Resources;response;Review Literature;Risk;Risk Factors;Role;Shapes;Smoking;Stimulant;Study models;synthetic drug;synthetic opioid;Techniques;tool;Youth

PROJECT_TITLE: Synthetics in Combination (SYNC)

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetic Testing;Genetics;Lymphatic Research;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Vascular malformations occur when there is abnormal development of the body's blood or lymphatic vessels. They are a relatively common birth defect and can produce significant health issues in children and adults. By developing new diagnostic methods and trying to understand how these malformations form in the first place, we will expand available treatment options and improve the lives of individuals with vascular malformations.

PI_NAMEs: BENNETT, JAMES T (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: 3-Dimensional;Adult;Alleles;Architecture;Area;Arteries;Arteriovenous malformation;Automobile Driving;Bar Codes;biobank;Biology;Biopsy;Blood;Blood capillaries;Blood Vessels;cell free DNA;cell type;Cells;Child;Clinical Data;Clinical Trials;Congenital Abnormality;Data;Development;Diagnosis;Diagnostic;Diagnostic Procedure;DNA;DNA analysis;efficacy evaluation;Endothelial Cells;Enrollment;exome sequencing;experimental study;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic testing;Genomic DNA;Genotype;Goals;Health;Heterogeneity;Image;improved;in vivo;Individual;inhibitor;KRAS2 gene;Lesion;Leukocytes;Link;liquid biopsy;Lymph;Lymph Node Mapping;lymphatic malformations;lymphatic vessel;Magnetic Resonance Imaging;malformation;MAP Kinase Gene;MAP2K1 gene;Maps;Measures;Methods;Molecular Diagnosis;molecular diagnostics;Morbidity - disease rate;Morphogenesis;mosaic;mosaic variant;Mosaicism;multidisciplinary;multiple omics;mutant;Mutation;Mutation Detection;mutational status;Nature;noninvasive diagnosis;novel;novel diagnostics;Oncogenes;Operative Surgical Procedures;Paracrine Communication;Pathology;Pathway interactions;Patients;Pericytes;Phenotype;PIK3CA gene;PIK3CG gene;Plasma;Play;Population;prospective;prospective test;Proto-Oncogene Proteins c-akt;Resected;Resolution;Retrospective cohort;Sampling;Slide;targeted treatment;Techniques;Technology;Testing;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomics;two-dimensional;Veins;Venous Malformation;Visualization;Work

PROJECT_TITLE: Mosaic: post-zygotic mutations in vascular malformations

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative The purpose of this training program is to create a new cadre of researchers capable of creating, implementing, evaluating, and translating methods, devices, algorithms, and systems to facilitate surgery and intervention. Thematically, the program has a central focus – innovative platform technologies for treatment and discovery.

PI_NAMEs: MIGA, MICHAEL IAN (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Engineering;innovation;Intervention;Operative Surgical Procedures;Research;Training Programs

PROJECT_TITLE: Training Program for Innovative Engineering Research in Surgery and Intervention


ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The overall goal of this training program is to develop highly trained research scientists who understand how to address important scientific questions and are ready to pursue diverse biomedical careers that support the NIH mission. The program also provides trainees with an understanding of the mechanisms involved in health and disease, giving our training program high relevance to public health.

PI_NAMEs: BENOVIC, JEFFREY L;MERRY, DIANE E (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TITLE: Training Grant in Cellular, Biochemical and Molecular Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative  Tumor cells are often characterized by genomes with high levels of single-base mutations, deletions/duplications, translocations, and/or aneuploidy. We will use the yeast Saccharomyces cerevisiae as a model system to examine the mechanisms responsible for these types of genetic instability.

PI_NAMEs: PETES, THOMAS  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Accounting;Aneuploidy;ataxia telangiectasia mutated protein;ATR gene;base;Base Composition;Biological Models;cancer cell;carcinogenesis;causal variant;Cells;Centromere;Chromosomes;Cytosine;Data;Deamination;DNA;DNA biosynthesis;DNA Polymerase III;DNA Repair;Enzymes;Event;experimental study;familial colorectal cancer;GC gene;Genes;Genetic;Genetic Nondisjunction;Genetic Recombination;Genome;Genome Stability;Genomic Instability;Goals;Guanine + Cytosine Composition;Histone H2A;Human;Induced Mutation;Maps;Meclp;Microsatellite Instability;Mismatch Repair;Modeling;Molecular Chaperones;Mutation;neoplastic cell;Normal Cell;novel;Phenotype;Phosphorylation;Proteins;Regulation;replication stress;Research;Saccharomyces cerevisiae;Single-Stranded DNA;success;System;Tandem Repeat Sequences;TEL1 Gene;telomere;Testing;tumor;yeast protein;Yeasts

PROJECT_TITLE: Genetic regulation of genome stability in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Social Determinants of Health

PHR: Project Narrative Population- and episode-based alternative payment models (APMs) are highly relevant to surgical care and hold organizations financially accountable for the quality and costs of care; however, these APMs are not designed to protect access or outcomes for racial/ethnic minorities and individuals with low socioeconomic status, vulnerable groups that already face significant surgical disparities. To increase understanding about the potential for these APM types to worsen disparities, this study will examine and compare how participation in major Medicare fee-for-service APMs impacts surgical access and outcomes for vulnerable patients across insurance coverage type. Results will inform design, selection, and refinement of models to continue nationwide reform while safeguarding the care of vulnerable individuals.

PI_NAMEs: IBRAHIM, SAID A;LIAO, JOSHUA M;NAVATHE, AMOL S (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: access disparities;Accountability;accountable care organization;acute care;Affect;black patient;bundled payment;care costs;care episode;care providers;Caring;Coronary Artery Bypass;cost;Data;design;Disparity;disparity reduction;econometrics;Equity;ethnic minority;Excision;experience;experimental study;Face;Fee-for-Service Plans;hospital readmission;Hospitalization;Hospitals;Incentives;Individual;innovation;inpatient surgery;insight;Insurance Coverage;Intestines;Length of Stay;low socioeconomic status;Lower Extremity;Medicaid;Medicare;Methodology;model design;Modeling;mortality;Operative Surgical Procedures;Outcome;outcome disparities;Patient Care;patient population;Patient Selection;Patient-Focused Outcomes;Patients;payment;Peer Group;Performance;Physicians;Policies;Policy Maker;Population;population based;Procedures;Provider;racial minority;Replacement Arthroplasty;Research;Risk;scale up;Services;Socioeconomic Status;Spinal Fusion;Surgeon;surgical disparities;Time;Vulnerable Populations

PROJECT_TITLE: The impact of population and episode-based payment models on surgical disparities

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative (Overall) Adolescent idiopathic scoliosis (AIS) is the most common pediatric musculoskeletal disorder in children, causing disfigurement, pain, and other physiologic impairments later in life. The name “idiopathic” conveys the fact that the pathogenesis of AIS has been poorly understood due to gaps in fundamental knowledge of the disease. Our purpose is to build upon prior discoveries of our program and further elucidate the factors that cause and exacerbate AIS to aid diagnosis and development of noninvasive biologic treatment.

PI_NAMEs: AHITUV, NADAV ;SOLNICAKREZEL, LILIANNA ;WISE, CAROL A (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Alleles;Animal Model;ATAC-seq;Automobile Driving;Award;Back Pain;Biological Assay;Biological Response Modifier Therapy;boys;candidate validation;Cartilage;Cells;Child;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;collaborative approach;CRISPR/Cas technology;Data;data integration;Deformity;Development;Diagnosis;Disease;disease model;Disproportionately impacts women;DNA Sequence Alteration;Elements;Engineering;Enhancers;Epigenetic Process;Ethylnitrosourea;Etiology;exome sequencing;experimental study;Extracellular Matrix;Family;Female;Female Adolescents;Fiber;Fishes;forward genetics;Functional disorder;gene discovery;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Screening;Genetic study;Genetic Transcription;Genetically Engineered Mouse;genome editing;genome wide association study;Genomic Segment;Genomics;girls;high risk;Hospital Charges;Human;Human Genetics;human model;human tissue;Idiopathic scoliosis;Impairment;Induced Mutation;innovation;Investigation;Knock-out;Knockout Mice;Knowledge;knowledge integration;Lead;Life;Link;male;Maps;Medical;MMP14 gene;Modeling;Molecular;Monitor;mouse model;Mus;Musculoskeletal Diseases;mutant;Mutation;Names;Nature;nonsynonymous mutation;novel;null mutation;Pain;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;postnatal;Predisposition;prevent;Preventive;Procedures;Productivity;programs;Refractory;Regulation;Regulatory Element;Resources;reverse genetics;Risk;risk variant;Role;School-Age Population;scoliosis;Sex Distribution;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;somitogenesis;Specificity;Spinal;Spinal Diseases;Susceptibility Gene;System;Tail;Testing;Therapeutic Studies;therapeutic target;Tissues;tool;transcriptomics;Untranslated RNA;Variant;Vertebral column;Work;Zebrafish

PROJECT_TITLE: Developmental Mechanisms of Human Idiopathic Scoliosis


PI_NAMEs: WISE, CAROL A (contact)

PROJECT_TERMS: Acceleration;Achievement;Adherence;Administrator;Adolescent;Advisory Committees;Agreement;Animals;Area;Award;Budgets;California;Caring;Child;Communication;Data;Data Set;data sharing;data submission;Deformity;Deposition;Development;Ensure;Ethics;Funding;gene discovery;Genes;Genomics;Goals;Guidelines;Human;human subject protection;IACUC;Idiopathic scoliosis;innovation;Institution;Institutional Review Boards;Knowledge;large scale data;Manuscripts;Measures;Medical center;medical schools;meetings;Modeling;Monitor;multiple omics;Musculoskeletal Diseases;Online Systems;Participant;Pathogenesis;Pediatric Hospitals;Persons;Policies;Preparation;Productivity;programs;Publications;Quality Control;Regulation;relational database;Research;Research Personnel;Resources;San Francisco;Specific qualifier value;Spinal;Texas;timeline;tool;tool development;United States National Institutes of Health;Universities;Vertebral column;virtual;Visualization;Washington;web portal;Work;Zebrafish


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Pancreatic Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE  The overarching goal of the Africa Hepatopancreaticobiliary Cancer Consortium is to harness resources and expertise across the African Continent and the United States to investigate the influences of lifestyle, environment, viral and host biological factors on the development of hepatopancreaticobiliary cancers to inform strategies for risk prevention, early detection, and improved survival of patients with these cancers. In this R13 grant proposal, we will organize a series of scientific workshops and training activities in the hepatobiliary and pancreatic cancers to augment our existing collaborations for multidisciplinary investigations in the cancer continuum – from risk and prevention to cancer incipience and progression to treatment and survivorship. Our collaborative research is expected to yield novel insights into the etiology and biology of hepatobiliary and pancreatic cancer for translation to practical actions to address the perennially high incidence and mortality of these cancers in individuals of African descent (African Americans and native Africans).

PI_NAMEs: ROBERTS, LEWIS R (contact)

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Address;Africa;African;African American population;African ancestry;Age;American;anti-cancer research;Applications Grants;Asian population;Award;Biological Factors;Biology;cancer risk;career;career development;Cholangiocarcinoma;Clinic;Collaborations;curative treatments;Data;Death Rate;design;Development;Diagnosis;diagnostic value;Discipline;Distant;Early Diagnosis;Educational workshop;empowerment;Environment;Epidemiology;Ethnic Origin;Ethnic Population;Etiology;European;experimental study;Faculty;Foundations;Funding;Genomics;Goals;graduate student;Grant;Health;hepatobiliary cancer;improved;Incidence;Individual;insight;Institution;Interdisciplinary Study;Investigation;Joints;Knowledge;Laboratories;lectures;Life Style;Liver;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;member;Mentors;mortality;multidisciplinary;novel;Organ;Outcome;Pancreas;Patient Recruitments;Patients;Pilot Projects;Population;Prevention;Primary Neoplasm;Prognosis;Prognostic Factor;Psychosocial Factor;Public Health;Publications;racial population;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Resource Allocation;Resources;Risk;Science;Scientific Societies;Scientist;Series;Site;skills;survivorship;symposium;Technology;technology/technique;Training;Training Activity;Translations;Treatment outcome;Tumor Biology;United States;Viral;working group;Writing

PROJECT_TITLE: Africa Hepatopancreatobiliary Cancer Consortium


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Prevention

PROJECT_TERMS: Adolescent;Adult;Affect;Alleles;ATAC-seq;Award;Back Pain;biobank;Biological;Biological Response Modifier Therapy;bone quality;boys;Candidate Disease Gene;candidate identification;Cartilage;Cells;Child;Childhood;clinical translation;cohort;Collagen Type XI;Connective Tissue Diseases;cost;Coupled;CRISPR/Cas technology;Databases;Deformity;Development;Diagnosis;Early Diagnosis;Embryo;Engineering;Epiphysial cartilage;Ethylnitrosourea;Etiology;experimental study;Extended Family;Extracellular Matrix;Family;Female;Functional disorder;gene discovery;Genes;genetic architecture;Genetic Induction;Genetic Recombination;Genetic Screening;Genetically Engineered Mouse;genome sequencing;genome wide association study;Genomics;girls;Goals;Growth;Health;high risk;Histologic;Human;Human Genetics;Idiopathic scoliosis;Image;Immunohistochemistry;inducible Cre;Intervention;Intervertebral disc structure;Knock-in;Knock-in Mouse;Knockout Mice;LacZ Genes;Life;Matrix Metalloproteinases;Mechanics;Medical;Meta-Analysis;MMP14 gene;Modeling;Molecular;Monitor;Morphology;multi-ethnic;Mus;Musculoskeletal Diseases;mutant;Mutation;novel;offspring;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Phenotype;Physiological;postnatal;Prevention;Preventive;Productivity;programs;progression risk;Resistance;Reverse engineering;Risk;Risk Factors;risk variant;Role;School-Age Population;scoliosis;sex;Sex Bias;sexual dimorphism;single-cell RNA sequencing;skeletal;skeletal disorder;spatiotemporal;Spinal;Susceptibility Gene;synergism;Testing;Tissues;tool;transcriptomics;Untranslated RNA;Variant;Vertebral column;whole genome;Zebrafish

PROJECT_TITLE: Human Genetics and Clinical Translation


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The primary focus of the SUPERS@PENN program is to enrich the undergraduate experience by educating students on the science behind cancer and radiation research with a particular emphasis on recruitment and retention of students from underrepresented populations into the program and ultimately the research career pipeline. We propose that this cornerstone experience at a world-class institution (University of Pennsylvania) which is largely unavailable to the majority of undergraduates in the United States, will encourage them to apply to graduate school programs that eventually leads to pursuit of careers in biomedical research, particularly cancer and radiation research. By completing the stated goals set forth in this proposal, we anticipate that we will increase the quantity, quality and diversity of the next generation of scientists working in cancer and particularly radiation research.

PI_NAMEs: DORSEY, JAY FITZGERALD (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: academic program;anti-cancer research;Bioethics;Biomedical Research;Cancer Biology;Cancer Center;cancer imaging;cancer therapy;career;Career Choice;CCL7 gene;Chalk;Collaborations;college;Critical Thinking;Data;Discipline;Education;Educational process of instructing;Electronic Mail;Equipment;Evaluation;experience;Faculty;Female;field study;Foundations;Functional disorder;Funding;Gender;Goals;Graduate Degree;graduate school;Grant;Hour;Image;improved;Institution;interest;International;Interview;Journals;Laboratories;Laboratory Research;learning strategy;lectures;Malignant Neoplasms;Measures;medical schools;Mentors;Methodology;Methods;Minority;Minority Enrollment;Modality;next generation;Online Systems;Oral;ovid;Participant;Patient Recruitments;Pennsylvania;Physics;Postbaccalaureate;Process;Productivity;programs;Public Speaking;Radiation;Radiation Oncology;Radiation Physics;Radiation therapy;Radiobiology;Radiology Specialty;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;School Enrollments;Schools;Science;Scientist;Series;social media;Social Network;socioeconomic disadvantage;Student recruitment;student retention;Students;Study Section;success;summer research;supportive environment;Surveys;Talents;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;Visit;web site

PROJECT_TITLE: Summer Undergraduate Program to Educate Radiation Scientists (SUPERS)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Follicular lymphomas are characterized by translocations in BCL2 and somatic mutations of epigenetic modifier genes such as EZH2. In germinal centers mutant EZH2 epigenetically reprograms B-cells to form an aberrant immunological niche. Understanding how EZH2 mutant follicular lymphomas survive in their unique rich microenvironment will advance our knowledge of the underlying mechanisms by which EZH2 mutations drive lymphomagenesis and inform the design and preclinical development of new treatment strategies to prevent disease progression and transformation.

PI_NAMEs: BEGUELIN, WENDY  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Affinity;Apoptotic;B-Cell Lymphomas;B-Lymphocytes;Back;BCL2 gene;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Centrocyte;Clinical Trials;Darkness;Data;Dendrites;Dendritic Cell Therapy;Dendritic Cells;design;Disease Progression;Epigenetic Process;EZH2 gene;Failure;FDA approved;Follicular Dendritic Cells;Follicular Lymphoma;gain of function mutation;Genes;Genetic;Goals;Helper-Inducer T-Lymphocyte;Histologic;Human;Immune;Immune checkpoint inhibitor;Immunity;Immuno-Chemotherapy;Immunologic Surveillance;immunological synapse;immunological synapse formation;Immunologics;in vivo;Indolent;inhibitor;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Light;Lymphoma;Lymphoma cell;Lymphomagenesis;mimetics;mutant;Mutation;neoplastic;novel;novel therapeutic intervention;Patients;permissiveness;Precision therapeutics;preclinical development;prevent;programs;Proliferating;receptor;recruit;Refractory;Regimen;Relapse;Resistance;Signal Transduction;Somatic Mutation;Structure of germinal center of lymph node;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy resistant;tumor;tumor eradication;Work

PROJECT_TITLE: Preventing follicular lymphoma progression and transformation through precision therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rehabilitation

PI_NAMEs: SOLNICAKREZEL, LILIANNA  (contact)

PROJECT_TERMS: Adolescent;Adopted;Adult;Affect;Alleles;Animal Model;Atlases;base;Bone Density;candidate validation;Chemicals;Child;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Critical Pathways;Databases;Defect;Deformity;Development;Diagnosis;Engineering;Essential Genes;Ethylnitrosourea;exome;exome sequencing;experience;Extracellular Matrix;Family;Fertilization;Fiber;Funding;Genes;Genetic;genetic approach;Genetic Screening;Genetic study;Genome;genome editing;Genome engineering;genome sequencing;Genomics;Goals;Grant;Human;human disease;Human Genetics;Idiopathic scoliosis;Induced Mutation;Inflammation;innovation;loss of function;Maintenance;Maps;Mediating;Medical;Missense Mutation;Modeling;Modernization;Molecular;Molecular Analysis;Monitor;Morphogenesis;Morphology;Mus;Muscle;Mutagens;mutant;Mutation;Nature;neuroinflammation;Nonsense Mutation;nonsynonymous mutation;null mutation;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiology;Population;prevent;prime editing;Process;Productivity;programs;Proteins;pulmonary function;Regulatory Element;Research;reverse genetics;scoliosis;screening;Sex Distribution;skeletal;SOX6 gene;Spinal Canal;Spinal Diseases;spine bone structure;Structural defect;synergism;Testing;Tissue Banks;Tissues;transcriptome;Transgenic Organisms;Variant;Vertebral column;whole genome;young woman;Zebrafish

PROJECT_TITLE: Forward and Reverse Genetic Studies of AIS and Spine Development in Zebrafish


ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE The goal of this training grant is to prepare the next generation of scientists who will conduct high quality research leading to new discoveries in biomedicine. The research focus of students who train in our program is to understand fundamental mechanisms in signaling and cellular regulation, an area which is key to the discovery of new therapeutic treatments for human diseases such as cancer, diabetes, inflammation, heart disease, immunological and neurological disorders, and birth defects, and forms the foundation for modern research in biology and medicine.

PI_NAMEs: AHN, NATALIE G. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: cell growth regulation;pre-doctoral;Signal Transduction;Training Programs

PROJECT_TITLE: Predoctoral Training Program in Signaling and Cellular Regulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE The research described in this proposal challenges longstanding views that the aged brain is unable to combat the effects of aging due to a lack of inherent plasticity, which facilitates permanent age-related regenerative and cognitive impairments. By exploring how regenerative and cognitive functions can be enhanced through increased systemic Gpld1 we aim to move closer towards realizing the possibility of reversing age-related cognitive impairments in the elderly. Moreover, this study will have significant translational potential, revealing pathways that could be targeted for novel therapies to ameliorate age-related neurodegenerative diseases such as Alzheimer’s disease.

PI_NAMEs: VILLEDA, SAUL A (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adherence;Adult;adult neurogenesis;age effect;age related;age related neurodegeneration;Age-associated memory impairment;age-related disease;Aging;aging brain;aging hippocampus;Alzheimer's Disease;Alzheimer's disease patient;Animal Model;animal old age;Antisense Oligonucleotides;arm;Behavioral Paradigm;Bioluminescence;Blood;Brain;Cardiovascular system;Cognition;cognitive benefits;cognitive function;cognitive process;combat;conditioned fear;Confocal Microscopy;Data;Dementia;Dioxygenases;Disease;Elderly;Epigenetic Process;Exercise;fitness;frailty;Genetic;Glycosylphosphatidylinositols;Health;hippocampal atrophy;Hippocampus;Human;Immunohistochemistry;Impaired cognition;improved;in vivo;Incidence;Individual;insight;juvenile animal;Kinetics;Knockout Mice;Knowledge;Learning;Light;Liver;liver function;Mediating;Memory;Molecular;mouse model;Mus;Neurodegenerative Disorders;neurogenesis;new therapeutic target;novel therapeutics;old mice;Parabiosis;Pathway interactions;Perception;phospholipase D1;Plasma;Population;Predisposition;Process;Radial;regeneration function;regenerative;Regenerative capacity;Rejuvenation;Research;RNA Interference;Role;Running;sedentary;Testing;theories;Therapeutic;transcriptome sequencing;translational potential;Up-Regulation;Viral;water maze

PROJECT_TITLE: Pro-youthful role of Gpld1 on regenerative and cognitive function in the aged brain


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

PI_NAMEs: AHITUV, NADAV  (contact)

PROJECT_TERMS: Adolescent;Affect;ATAC-seq;Biological Assay;Candidate Disease Gene;candidate selection;Cartilage;Cell Line;cell type;Cells;Chondrocytes;Chromatin;chromatin immunoprecipitation;cost;CRISPR/Cas technology;Data;Development;Disease;Disease Pathway;DNA Sequence Alteration;Encyclopedias;Engineering;Enhancers;epigenetic regulation;exome sequencing;experimental study;Extracellular Matrix;Female;functional genomics;Gene Expression;Genes;Genetic;genome sequencing;genome wide association study;genomic data;Genomics;Human;human disease;Idiopathic scoliosis;in vivo;Individual;insight;Intervertebral disc structure;Knock-out;knockout gene;Knockout Mice;Lead;Literature;male;Modeling;Molecular Conformation;mouse genome;Mus;Musculoskeletal;Mutagenesis;Mutate;Mutation;Names;novel;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Phenotype;Population;Predisposition;Progressive Disease;promoter;Regulation;Regulatory Element;Reporting;Research Personnel;Risk;RNA;Role;scoliosis;Sex Bias;Single Nucleotide Polymorphism;single-cell RNA sequencing;Spinal;Spinal Cord;Symptoms;synergism;Tail;Techniques;Technology;Tissues;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;whole genome;Work;Zebrafish

PROJECT_TITLE: Non-coding/epigenetic regulation


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Human Genome;Lung;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative Acute lung injury (ALI) is a life-threatening disease characterized by plasma leakage, increased white blood cell influx and cytokine generation. Although incremental progress has been made in managing patients suffering from ALI, the search continues for treatments to reduce the unacceptably high mortality rate in these patients. The proposed studies will characterize the role of cyclic AMP response element binding protein in generating a population of reparative alveolar macrophages that promote tissue repair after lung vascular injury, thus pointing the way to development of novel therapeutic approaches for treatment of ALI.

PI_NAMEs: MEHTA, DOLLY  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acetyl Coenzyme A;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alveolar;Alveolar Macrophages;ATAC-seq;BACH2 gene;Binding;Biological Assay;Cell Nucleus;cell type;ChIP-seq;Chromatin;chromatin remodeling;Critical Illness;Cyclic AMP;Cyclic AMP Response Element;Cyclic AMP-Responsive DNA-Binding Protein;cytokine;Data;Death Rate;Development;Disease;Endothelium;Epigenetic Process;Epithelium;Exhibits;Extravasation;Fluid Balance;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Histone Acetylation;histone modification;Homeostasis;Immune;Impairment;Inflammatory;Inflammatory Response;Injury;injury and repair;insight;Instruction;interstitial;ITGAM gene;ITGAX gene;Leukocytes;Life;Lung;Lung Capacity;lung injury;lung repair;lung vascular injury;Macrophage;Mitochondria;monocyte;mortality;multiple omics;Mus;Myeloid Cells;novel;novel therapeutic intervention;Nuclear;Pathway interactions;Patients;pharmacologic;Plasma;Population;prevent;Production;programs;promoter;protein expression;Pseudomonas aeruginosa infection;Pyruvate Dehydrogenase Complex;pyruvate dehydrogenase kinase 4;Recovery;Regulation;Regulatory Element;repair strategy;Research;restoration;Role;Sentinel;Signal Induction;Signal Pathway;single-cell RNA sequencing;Sorting;Source;Testing;Therapeutic;tissue injury;tissue repair;Tissues;transcription factor;transcriptome sequencing;vascular injury;Vascular Permeabilities

PROJECT_TITLE: CREB Instruction of Macrophage Fate and Lung fluid homeostasis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Respiratory viral infections are linked to the development of asthma and chronic obstructive pulmonary disease, but the enduring changes caused by infections that might explain chronic pathology are unknown. The ectopic development of solitary chemosensory cells (SCCs, tuft cells) after influenza infection represents a likely driver of viral-induced chronic disease, given that these cells are key modulators of both inflammation and tissue remodeling. Direct implication of SCCs and their effectors in regeneration and inflammation will validate SCCs as a potential therapeutic target in chronic lung diseases.

PI_NAMEs: VAUGHAN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Ablation;Acetylcholine;Address;Adult;Affect;Airway Fibrosis;airway hyperresponsiveness;Alveolus;Asthma;asthmatic;Blood;Body Weight decreased;Brush Cell;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Childhood Asthma;Chronic;Chronic Disease;chronic inflammatory lung disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Cicatrix;Cre driver;Cytokeratin;cytokine;Data;Development;Diphtheria Toxin;diphtheria toxin receptor;Disease;Distal;Effector Cell;Eicosanoids;eosinophil;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;Etiology;Exhibits;Exposure to;Frequencies;Gases;Genes;Genetic;Goblet Cells;helminth infection;Immunity;immunopathology;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;injured;Injury;Interleukin-13;Interstitial Lung Diseases;Intestines;Intraepithelial Neoplasia;Link;Lung;lung development;Lung Diseases;lung injury;lung pathogen;lung regeneration;Lymphoid;Measures;Mediating;Metaplasia;Modeling;mucosal site;Mus;Natural regeneration;neutralizing antibody;Nippostrongylus;Organoids;Output;overexpression;Paracrine Communication;Parasites;pathogen;Pathogen detection;Pathologic;Pathology;Pathway interactions;Phenotype;Predisposition;preservation;prevent;Proliferating;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;Pyroglyphidae;repaired;Resolution;response;Risk Factors;Sensory;Signal Transduction;small molecule;surfactant;Testing;therapeutic target;Time;tissue regeneration;tissue repair;Tissues;tool;transcription factor;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Solitary chemosensory / tuft cells in lung regeneration and inflammation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PUBLIC HEALTH RELEVANCE Thousands of DNA variants may contribute to common diseases by affecting how well a gene is expressed, but the identity of these variants is unknown. The proposed study will identify specific DNA variants that alter gene expression level to influence risk of disease. The study will determine whether variants act differently in males and females; in the brain, liver, muscle, lung, and heart; and in or out of an inflamed environment. The results may lead to identification of new targets for drugs to treat common diseases.

PI_NAMEs: LOVE, MICHAEL ISAIAH;MOHLKE, KAREN L.;WON, HYEJUNG  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Acceleration;Achievement;adeno-associated viral vector;adenovirus mediated delivery;Affect;Algorithms;Alleles;Bar Codes;Biological Assay;Brain;Catalogs;cell type;Cells;Circulation;Clinical Research;Code;Communities;Complex;Controlled Study;Data;Data Collection;Dependovirus;Disease;disorder risk;DNA;Environment;Exhibits;experimental study;Female;Frequencies;Future;gene environment interaction;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomic Segment;genomic variation;Genomics;Goals;Health;Heart;Heterogeneity;Human;Human Genetics;human genomics;in vivo;Individual;Inflammatory;Libraries;Link;Liver;Lung;male;Measurement;member;Mus;Muscle;network models;new therapeutic target;Organ;Physiological;Physiology;Positioning Attribute;prediction algorithm;predictive modeling;Process;Protocols documentation;public health relevance;Rare Diseases;Regulatory Element;Reporter;Reporting;Research Personnel;risk variant;RNA;sex;Signal Transduction;Testing;Tissues;trait;transcription factor;Transcriptional Regulation;Untranslated RNA;Validation;Variant;Viral;Work

PROJECT_TITLE: Systematic in vivo characterization of disease-associated regulatory variants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE We have formulated a model for how changes in bacterial membrane bioenergetics (likely by sensing reactive oxygen species produced by the respiration-linked sodium pump NQR) might affect virulence factor production in V. cholerae. Results of the proposed research will not only enhance our understanding of the general bioenergetic pathways in V. cholerae, but will form a solid basis for future investigations of the molecular devices maintaining membrane respiration and their relevance in virulence. A more complete understanding of these mechanisms could ultimately lead to novel intervention therapies to treat human infectious diseases.

PI_NAMEs: HASE, CLAUDIA C (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: 3-Dimensional;Address;Affect;Antioxidants;Bacteria;Bacterial Infections;bacterial metabolism;Bacterial Physiology;Biochemical;Bioenergetics;Biological Assay;Cells;Communicable Diseases;Complex;complex IV;Cytoplasm;Development;Devices;Electron Transport;Electron Transport Complex III;Ensure;Environment;Enzymes;experimental study;Exposure to;extracellular;flexibility;fluorophore;Future;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;Generations;Genetic Transcription;Goals;Growth;Human;Hydroquinones;in vivo;Infection;insight;Investigation;Link;Membrane;Metabolic;Metabolism;Methods;microbial;microorganism;Modeling;Molecular;Monitor;mutant;Na(+)-K(+)-Exchanging ATPase;NADH;novel;Organism;Oxidases;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;periplasm;Physiology;Play;Post-Translational Protein Processing;Process;Production;Quinones;Reactive Oxygen Species;Regulation;Reporting;Research;Respiration;respiratory;response;Role;Signal Induction;Signal Transduction;Site;Site-Directed Mutagenesis;Small Intestines;Solid;Source;Stress;Sulfhydryl Compounds;Superoxides;System;Testing;Therapeutic Intervention;three dimensional structure;tool;transcription factor;treatment strategy;ubiquinol;ubisemiquinone;Vibrio cholerae;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: The role of NQR in ROS-dependent virulence regulation in Vibrio cholerae

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Adolescence represents a period in the life course when many individuals initiate tobacco, alcohol, marijuana, and other drug use, yet identifying youth who are at risk of experiencing problematic substance use during adulthood remains a challenging task. To improve the long-term success of school-based prevention programs, the current study seeks to expand our understanding of the factors that heighten young people’s risk of using and misusing substances in adulthood by focusing on the relational structures of adolescent peer networks. We evaluate how patterns of direct and indirect friendship ties in adolescence impact adult substance use behaviors and consider whether this relationship varies according to the stability of ties, individual-level characteristics (e.g., gender, sexuality), and school-community context; findings will inform the design of new interventions that leverage existing social ties and discourage the formation of risky relationships to promote long-term desistance from harmful substance use behaviors.

PI_NAMEs: MCMILLAN, CASSIE LEIGH (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent substance use;Adult;Alcohol consumption;Alcohols;Behavior;Benefits and Risks;Cessation of life;Characteristics;Communities;community based research;community partnership;contagion;course development;Data;Data Set;demographics;design;Development;Drug usage;early adolescence;Emotional;Evolution;experience;Friends;Friendships;Future;future epidemic;Gender;Goals;Health;Health behavior;high risk;high school;illicit drug use;improved;Individual;interest;Intervention;intervention program;Life Cycle Stages;lifetime risk;Link;Longitudinal Studies;Maintenance;Marijuana;Modeling;Names;National Institute of Drug Abuse;Outcome;Overdose;Participant;Pattern;peer;Peer Group;peer networks;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;prevent;Prevention program;Process;promote resilience;Reporting;Research;research study;resilience research;Resources;Respondent;response;Risk;Risk Behaviors;Risk Factors;risk mitigation;Role;Rural;school environment;Schools;secondary analysis;Sexuality;Shapes;social;Social Network;Social support;Statistical Methods;Structure;Students;substance misuse;substance use;substance use prevention;substance user;success;Surveys;Testing;theories;Time;Tobacco;trait;transition to adulthood;Vacuum;Work;young adult;Youth

PROJECT_TITLE: The impact of longitudinal social networks on young adult substance use and misuse

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Type 2 conventional dendritic cells (cDC2s) play critical roles in type 2 inflammation and humoral immunity. We previously identified CD301b+ cDC2s as a functionally and phenotypically distinct subset of mouse cDC2s that expands during type 2 inflammation and is required for type 2 immune responses to allergens and helminth parasites, but their differentiation mechanism remains unknown. This grant application proposes to identify the cellular origin and the molecular mechanism of their differentiation, which potentially helps us to understand the etiology of allergic and autoimmune diseases.

PI_NAMEs: KUMAMOTO, YOSUKE  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: adaptive immunity;Adoptive Cell Transfers;Allergens;Allergic Disease;Applications Grants;Autoimmune Diseases;Bioinformatics;Blood;Bone Marrow Cells;Categories;Cell Differentiation process;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;CRISPR/Cas technology;Data;Dendritic Cells;Dependence;Development;Disease;Etiology;ETV3 gene;experimental study;Family;Gene Expression;Genes;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;helminth infection;Helminths;Heterogeneity;Homing;Homologous Gene;Human;Humoral Immunities;Hypersensitivity;Immune response;Immunity;Inflammation;IRF4 gene;ITGAM gene;knock-down;lymph nodes;Maintenance;migration;Molecular;monocyte;Mouse Strains;mRNA Expression;Mus;Natural Immunity;Organ;Parasites;Peripheral;Phenotype;Play;Population;precursor cell;protein expression;Regulation;Reporter;Role;selective expression;single-cell RNA sequencing;Skin;Spleen;Techniques;therapeutic target;Tissues;transcription factor

PROJECT_TITLE: Mechanism of cDC2 subset differentiation in peripheral organs

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: There is a shortage of researchers who have skills in both statistical or molecular genetics and psychiatric epidemiology. Such individuals are needed to increase our understanding of the causes and trajectories of psychiatric disorders, so that better prevention and treatments can be developed. This training grant will educate three pre-doctoral and three postdoctoral trainees in psychiatric, behavioral, statistical and molecular genetics and neuroscience.

PI_NAMEs: NEALE, MICHAEL CHURTON (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Genetic

PROJECT_TITLE: ResearchTraining: Psychiatric and Statistical Genetics.


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE and PUBLIC HEALTH RELEVANCE It is well-established that cancer cells are generally very resistant to radiation. In the proposal we aim to characterize a novel adaptative mechanism of radioresistance involving the arrangement of the electron transport chain complexes into high molecular weight mitochondrial supercomplexes.

PI_NAMEs: GRIGUER, CORINNE E. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: aerobic glycolysis;Affect;Amino Acids;Animal Model;Bioenergetics;Biological Markers;Biopsy Specimen;cancer cell;Cells;Cellular Stress;Clinical;Complex;Coupled;cytochrome c oxidase;Data;Development;Dissociation;DNA;Electron Transport;Glioblastoma;Glioma;glioma cell line;Glycolysis;Goals;Hydrogen Peroxide;Hypoxia;in vivo;inhibitor;Ionizing radiation;Laboratories;Lipids;Long-Term Survivors;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Methylation;MGMT gene;Mitochondria;mitochondrial genome;mitochondrial metabolism;Modeling;Molecular;Molecular Target;Molecular Weight;N-terminal;neoplastic cell;normoxia;novel;novel therapeutics;Nuclear;Outcome;oxidative damage;Oxidative Phosphorylation;patient derived xenograft model;Patients;Phenotype;Physiological;pre-clinical;Process;Production;prognostic tool;programs;promoter;prospective;Protein Isoforms;Proteins;public health relevance;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Reactive Oxygen Species;Regulation;Research;Resistance;Resistance development;respiratory;response;Role;Sampling;standard of care;stem cells;Structure;Superoxides;Therapeutic;therapy resistant;Treatment Efficacy;Treatment Failure;tumor;U251;Work

PROJECT_TITLE: Mitochondria electron transport chain complexes adaptative responses to cellular stress

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The pathogenesis of COPD and IPF is poorly understood. In this program project we have integrated the expertise of investigators from COPD and IPF communities, both basic and translational/clinical researchers, to come together to better understand the pathogenesis of these chronic lung diseases, and hopefully identify new molecular targets in the treatment of these dreadful diseases in the future.

PI_NAMEs: CHOI, MARY E (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Adherence;Age;airway epithelium;Airway Fibrosis;Alveolar Macrophages;Animal Model;Binding;biobank;Biological;Bleomycin;Bronchoscopy;Cell Culture Techniques;Cells;CHI3L1 gene;Chitinase;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical;clinical diagnosis;cohort;Communities;Data;data management;Data Reporting;data sharing;database of Genotypes and Phenotypes;Development;Disease;disease diagnosis;Ensure;Epigenetic Process;Epithelial Cells;Experimental Designs;Exposure to;exposure to cigarette smoke;Fibrosis;Foundations;Funding;Future;Gene Expression;gene regulatory network;Genetic;Genomics;glycosylation;Goals;Grant;Hand;Health;Human;human disease;Human Resources;idiopathic pulmonary fibrosis;Image;Institution;Link;Lung;lung development;Lung Diseases;lung volume;Mediating;meetings;member;Metabolic dysfunction;Metabolic Pathway;Metadata;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Modification;Molecular;Molecular Target;mouse model;Multiomic Data;Mus;Pathogenesis;Pathway Analysis;Pathway interactions;Phenotype;Physiology;PINK1 gene;Plasma;Policies;Poly I-C;Probability;Process;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Pulmonary Emphysema;Pulmonary Fibrosis;receptor;recruit;Reporting;Research;Research Activity;Research Personnel;Resources;respiratory;response;RIPK3 gene;Risk;Risk Factors;Role;Sampling;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;Site;Smoker;Spirometry;Structure of parenchyma of lung;Study models;Sum;Systems Analysis;Technology;Tissues;trafficking;transcriptome sequencing;Translating;United States National Institutes of Health;urinary;Usual Interstitial Pneumonia;Validation;Work

PROJECT_TITLE: Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CHOI, AUGUSTINE M (contact)

PROJECT_TERMS: Address;Administrative Coordination;Attention;Basic Science;Chronic Obstructive Pulmonary Disease;Cigarette Smoker;Clinical Research;Communication;Ensure;experience;Fibrosis;Goals;Hospitals;Human Resources;Institution;Medicine;meetings;member;Pathway interactions;Principal Investigator;Program Evaluation;Program Research Project Grants;programs;Public Health Schools;Pulmonary Emphysema;Reporting;Research;Research Activity;Research Personnel;Resources;Translational Research;Universities;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Emphysema;Genetics;Human Genome;Lung;Tobacco;Tobacco Smoke and Health

PI_NAMEs: QUACKENBUSH, JOHN  (contact)

PROJECT_TERMS: Address;Adherence;advanced analytics;analytical method;Basic Science;Bioinformatics;Biological;Candidate Disease Gene;Cells;Chitinase;Chronic Obstructive Pulmonary Disease;Cigarette Smoker;Clinical;Clinical Research;Complex;complex data;Computing Methodologies;Data;data integration;data management;Data Reporting;Data Set;data sharing;data streams;database of Genotypes and Phenotypes;design;Development;Disease;disease phenotype;Disease Progression;Elements;Ensure;Epigenetic Process;epigenetic variation;Evaluation;experience;Experimental Designs;Fibrosis;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genome;genome-wide;Genomics;Goals;Health;High-Throughput Nucleotide Sequencing;Human;human disease;human model;Infrastructure;insight;Investigation;Laboratories;Lung Diseases;male;Maps;Medicine;member;metabolomics;Methods;Mitochondria;Modeling;mouse model;Multiomic Data;multiple data types;Nature;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Play;Policies;Population;Process;programs;Proteins;Proteomics;Protocols documentation;Pulmonary Emphysema;Regulator Genes;Regulatory Element;Research Personnel;Resources;respiratory;response;Role;Severity of illness;Standardization;Study models;Surveys;System;Technology;Therapeutic Intervention;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;Translating;Translational Research;Translations;United States National Institutes of Health;Variant;women patients;Work

PROJECT_TITLE: Respiratory Computational Discovery Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Acute and chronic pancreatitis affect millions of people annually and currently lack effective treatment options. The mechanisms underlying pancreatic acinar-ductal metaplasia as a response to injury remains to be elucidated. Using novel mouse models, innovative single-cell sequencing techniques, and 3D cell-culture, this project aims to uncover mechanisms that link inflammation and KRAS mutations and proposes a potential therapeutic target for the treatment of acute pancreatitis.

PI_NAMEs: LI, ALINA LIN (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Acinar Cell;Acute;acute pancreatitis;Advisory Committees;Affect;Agreement;Alleles;Amino Acid Motifs;analog;ATAC-seq;Attenuated;Automobile Driving;Award;Back;Basic Science;Binding Sites;Biological Assay;Caerulein;career;Cell Culture Techniques;cell dedifferentiation;Cell Nucleus;cell type;Cells;Characteristics;Cholecystokinin;Chromatin;Chromatin Modeling;chromatin remodeling;chronic pancreatitis;Cleavage Under Targets and Release Using Nuclease;Colony-Stimulating Factor Receptors;combat;CSF3 gene;Data Analyses;Development;Doctor of Philosophy;Dose;Doxycycline;Duct (organ) structure;Ductal Epithelial Cell;effective therapy;Epithelial Cells;Epithelium;experience;Fellowship;Fibroblasts;Fos-Related Antigens;FOSL1 gene;Foundations;Functional disorder;Goals;Homeostasis;Individual;Inflammation;Injury;innovation;insight;Knockout Mice;Knowledge;KRAS oncogenesis;KRAS2 gene;Lesion;Link;Maintenance;Mediator;Medical center;Mentors;Metaplasia;Modeling;Molecular and Cellular Biology;mouse model;mutant;Mutation;new therapeutic target;novel;Oncogenic;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;Pancreatic Injury;Pancreatic Intraepithelial Neoplasia;pancreatic metaplasia;Pancreatitis;Persons;Phenotype;Physicians;Population;pre-doctoral;Precipitation;Process;protein complex;Public Health;Regulation;Research Personnel;Residencies;Resources;response to injury;Role;Scientist;Signal Pathway;Signal Transduction;single cell sequencing;stem-like cell;Techniques;Testing;Therapeutic Intervention;therapeutic target;three dimensional cell culture;tissue regeneration;Tissues;Training;transcription factor;Translational Research;Universities;Up-Regulation

PROJECT_TITLE: Elucidating the role of Fra1 in pancreatic Kras-driven acinar to ductal metaplasia