ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Colorectal Cancer (CRC) screening rates among Blacks served by federally qualified health care centers across Brooklyn are low. We aim to improve CRC screening rates through proactive outreach and navigation and study its implementation and cost.

PI_NAMEs: SHAUKAT, AASMA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Reducing Disparities in Colorectal Cancer Screening through Proactive Outreach and Navigation in federally qualified health care centers in Brooklyn


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WALTHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative We propose to harness the synaptogenic potential of Sema4D/Plexin B1 signaling to enhance inhibition in neural circuits by increasing GABAergic synapse number. This approach would be beneficial to preventing the establishment of epilepsy, halting its progression, or suppressing hyperexcitability during a seizure event. The proposed studies provide a unique opportunity to determine whether Sema4D, or ideally in the future, small molecules that activate Plexin B1, could be a novel therapeutic strategy for preventing or curing epilepsy.

PI_NAMEs: PARADIS, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Address;Adult;Benzodiazepines;Biological;Boston;Brain;CD100 antigen;Cell surface;Cells;Chronic;Collaborations;Data;density;dentate gyrus;Diazepam;Drug Modulation;Drug Targeting;Electric Stimulation;Electrophysiology (science);Epilepsy;Epileptogenesis;Event;Extracellular Domain;FDA approved;Frequencies;Future;Goals;Hippocampus;Human;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;Infusion procedures;Inhibitory Synapse;Injections;Integral Membrane Protein;Intervention;Intravenous infusion procedures;Marketing;Medical emergency;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Neonatal;neural circuit;Neurons;novel;novel strategies;novel therapeutic intervention;novel therapeutics;optimal treatments;Patients;Pediatric Hospitals;Pentylenetetrazole;Persons;Pharmaceutical Preparations;plexin;pre-clinical;preclinical study;prenatal;prevent;Proteins;receptor;receptor function;Refractory;Reporting;Risk;Rodent;Rodent Model;Route;Seizures;Semaphorins;Severities;Signal Pathway;Signal Transduction;Slice;small molecule;Sodium Channel;Status Epilepticus;success;Synapses;synaptogenesis;Techniques;Tertiary Protein Structure;Testing;Therapeutic;Time;trafficking;translatable strategy;translational potential;treatment strategy;Viral;Virus

PROJECT_TITLE: Semaphorin-Dependent GABAergic Synapse Formation: A Novel Approach to Increasing Inhibition in the Intact Brain

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: RELEVANCE TO PUBLIC HEALTH In both health and disease, all cells in the body respond to engagement with specific proteins in their environment, but the molecular basis of many such interactions is poorly understood. Through the development of new tools that can parse the molecular determinants of protein-protein interactions and the signals that these complexes transmit into the cell, novel insights will be gained that will then be further leveraged to precisely tailor new protein drugs and cellular therapeutics.

PI_NAMEs: SARKAR, CASIM  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Agonist;Amino Acids;antagonist;Antibody Binding Sites;Area;Biochemical;Biological;Biological Assay;Biology;Cell Surface Receptors;Cell Therapy;Cells;Clinical;Complex;Computer Models;conflict resolution;design;Development;Disease;effective therapy;Engineering;Environment;Experimental Models;Goals;Health;Hot Spot;Human;implicit bias;Individual;insight;Laboratories;lens;Ligands;Maps;Methodology;Methods;Molecular;novel;Outcome;Pharmaceutical Preparations;Process;programs;protein protein interaction;Proteins;Public Health;receptor;receptor binding;Receptor Signaling;Research;response;Signal Transduction;Specificity;tool;transmission process;Vision

PROJECT_TITLE: Analysis and engineering of cell signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on identifying previously unappreciated molecular/cellular mechanisms promoting synapse resilience to the detrimental impact of toxic tau oligomers in Alzheimer’s disease (AD). This is ultimately expected to drive the development of a novel, effective preventive/curative therapy for AD, thus improving these patients’ health while driving down the societal cost for their care, which is expected to increase to unbearable proportions by the year 2050. Thus, the proposed research is relevant to the part of NIH’s mission concerned with fostering creative discoveries and their application to advance the Nation’s capacity to protect and improve health.

PI_NAMEs: MICCI, MARIA-ADELAIDE ;TAGLIALATELA, GIULIO  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta oligomer;age related;aged;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Animal Behavior;Automobile Driving;base;Binding;Biochemistry;Brain;Caring;Cell Count;Cells;Clinical;Clinical Treatment;Cognitive;Cognitive deficits;cognitive function;Consensus;Creativeness;curative treatments;Data;Development;Disease;effective therapy;efficacy evaluation;Electrophysiology (science);Environment;Event;exosome;expectation;Fostering;Functional disorder;Genetic Materials;Goals;Health;Health Care Costs;Hippocampus;Human;improved;innovation;Link;Lipids;Literature;Mediating;Memory impairment;Messenger RNA;MicroRNAs;Mission;Molecular;Molecular Neurobiology;nerve stem cell;Neurofibrillary Tangles;neuromechanism;neuron loss;neuropathology;novel;Pathologic;Patients;Physiology;Play;pre-clinical;Predisposition;preservation;Preventive;Proteins;Public Health;Publishing;Qualifying;Reporting;Research;resilience;Resistance;Risk;Risk Factors;RNA;RNA analysis;Role;Senile Plaques;societal costs;stem cell biology;stem cell exosomes;Synapses;tau aggregation;tau Proteins;Therapeutic;Toxic Actions;transcriptome sequencing;Treatment Efficacy;United States National Institutes of Health;Vesicle;Work

PROJECT_TITLE: Promoting Brain Resilience to Alzheimer's Neuropathology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Clinical Research;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Wound healing is a fundamental biological process that is critical to the survival of all living organisms and cells of the monocyte/macrophage lineage play essential roles in this process. Macrophages are capable of performing a diverse array of tasks during wound healing, ranging from destructive killing functions to pro-healing and homeostatic duties, through their ability to adopt a wide spectrum of phenotypes. However, assessments of these phenotypes have so far been biased and incomplete. A goal of my laboratory over the next 5 years is to take advantage of newly developed single cell analysis techniques to determine, using unbiased methods, the actual phenotypes that macrophages adopt during normal and impaired wound healing and how these phenotypes are regulated. The overall vision guiding our approach is that by identifying novel regulators of macrophage function during wound healing, we can develop new approaches to manipulate inflammation and improve healing of poorly healing wounds, and in the process, generate a pipeline of candidate therapies to translate into clinical studies.

PI_NAMEs: KOH, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Adopted;Anti-diabetic Drugs;Biological Process;Categories;Cells;Chronic;Clinical Research;Clinical Trials;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;experimental study;Formulation;Future;Glyburide;Goals;healing;Human;Impaired healing;Impaired wound healing;Impairment;improved;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Investigational Drugs;Laboratories;Learning;Leg Ulcer;Macrophage;Methods;Modeling;monocyte;Mus;Muscle;Natural regeneration;novel;novel strategies;novel therapeutics;Organism;pathogen;Pathway interactions;Phase;Phenotype;Play;Population;Process;Publishing;Regulation;repaired;Research;Resolution;Role;Shapes;single cell analysis;Skeletal Muscle;Skin;Skin repair;Skin wound healing;Techniques;tissue repair;Tissues;Topical application;transcription factor;Translating;Vision;wound;wound healing

PROJECT_TITLE: Macrophage Phenotypes and Tissue Repair


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This project proposes to devise a dormant cancer cell biosensor by using intersectional genetics and synthetic biology technologies that will allow the identification, molecular profiling, and genetic manipulation of dormant cancer cells in vivo.

PI_NAMEs: BRAVO-CORDERO, JOSE JAVIER  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Ablation;Aftercare;Algorithms;Atlases;Biology;Biosensor;Bypass;cancer cell;Cancer Etiology;Cancer Relapse;cancer type;Cell surface;cell type;Cells;Cessation of life;Code;Computational Biology;cost;Custom;cytotoxic;Cytotoxin;design;Development;diagnostic value;Disease;Distant;DNA delivery;Enhancers;Frustration;Gene Expression Profile;Generations;Genes;Genetic;Genetic Engineering;genetic manipulation;genetic technology;Genetic Transcription;Genome;Genomics;Goals;Grant;high resolution imaging;Imaging technology;in vivo;insight;intravital imaging;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Profiling;mouse model;Names;Neoplasm Metastasis;neoplastic cell;new therapeutic target;next generation sequencing;Normal Cell;novel therapeutic intervention;novel therapeutics;Organ;Output;Patients;practical application;prevent;Process;programs;Property;Proteins;Psyche structure;Regulatory Element;Research;Research Design;Resolution;sensor;side effect;Source;Specificity;success;synergism;synthetic biology;Synthetic Genes;System;targeted delivery;targeted treatment;Technology;Testing;tool;Translating;tumor;two photon microscopy

PROJECT_TITLE: Intersectional genetics-based biosensors for dormant cancer cells


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: Study Narrative: This project will describe the clinical, pharmacokinetic and pharmacogenomic determinants of adverse drug reactions among people receiving 3HP for TPT in Uganda. The results of this study will inform clinical decisions for identifying patients at high risk for adverse drug reactions related to 3HP in the African setting.

PI_NAMEs: SEKAGGYA-WILTSHIRE, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Adverse drug effect;adverse drug reaction;Adverse event;Affect;African;Age;alternative treatment;Anti-Retroviral Agents;authority;Body Weight decreased;Categories;Cessation of life;Child;Clinical;clinical predictors;Clinical Trials;cohort;Cohort Studies;Collaborations;Coughing;Country;Cytochromes;Data;Development;Disease;drug induced liver injury;Drug Kinetics;efficacy evaluation;Enrollment;Evaluation;Event;Exanthema;experience;flu;follow-up;Genes;Genetic;Genetic Polymorphism;Genotype;gradient boosting;Guidelines;Health care facility;high risk;HIV;human leukocyte antigen testing;Hypotension;Immunologics;improved;Incidence;Individual;Informed Consent;Interruption;isoniazid;Laboratories;Link;Liver Function Tests;Machine Learning;Measures;Mycobacterium tuberculosis;Nested Case-Control Study;Neuropathy;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacogenetics;Pharmacogenomics;prevent;Preventive therapy;Preventive treatment;programs;Questionnaires;reactivation from latency;Recommendation;Regimen;Reporting;research clinical testing;response;rifapentine;Risk;Risk Factors;Safety;Sampling;scale up;sex;standard of care;Standardization;Statistical Methods;Symptoms;Testing;Transferase;Tuberculosis;Tuberculosis diagnosis;Uganda;uptake;Vision;World Health Organization

PROJECT_TITLE: Clinical Predictors of weekly Rifapentine/isoniazid related adverse drug reactions during national roll-out of tuberculosis preventive therapy

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative  The hippocampus is one of the few areas of the brain that integrate new neurons through adulthood. Adult- born neurons are known to improve spatial memory through processes that are not entirely understood. Here, we will test whether these neurons regulate the precision of brain circuits that encode spatial location. We expect to gain a better understanding of how adult neurogenesis improves cognition, which could open the door to potential new therapeutic targets for dementia and memory disorders.

PI_NAMEs: GONCALVES, JOSE TIAGO (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Acute;Adult;adult neurogenesis;Affect;Area;Back;Behavior;Brain;Brain region;Cells;Chronic;Code;Cognition;critical period;Cues;Cytoplasmic Granules;Data;Dementia;dentate gyrus;Discrimination;excitatory neuron;experimental study;Feedback;Genetic;granule cell;Head;Hilar;Hippocampus;Image;Impairment;improved;in vivo;Individual;Interneurons;Knowledge;Learning;Location;loss of function;Maps;Mediation;Memory;Memory Disorders;Methods;Modeling;Mus;neural;neurogenesis;Neurons;new therapeutic target;Performance;Phase;Play;Population;Process;Role;spatial memory;Specificity;Tactile;Testing;Time;treadmill;two photon microscopy;Walking

PROJECT_TITLE: Role of Adult Neurogenesis in Spatial Information Encoding in the Dentate Gyrus

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The rate of drug overdose deaths in the United States has doubled over the last decade, reaching a staggering loss of more than 70,000 individuals per year. The proposed work characterizes a neural circuit that underlies the increased drug consumption that takes place by some individuals following chronic drug use. The information gleaned from this work will inform potential treatment targets for reducing intake in substance abusers, lowering the risk of overdose death.

PI_NAMEs: PHILLIPS, PAUL E. M. (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;Animals;antagonist;Attenuated;Bilateral;Biochemical;cell type;Chronic;Cocaine;Cocaine Abuse;cocaine self-administration;cocaine use;Collection;Consumption;Contralateral;Corticotropin-Releasing Hormone;CREB1 gene;CRF receptor type 1;CRISPR/Cas technology;Dopamine;dopaminergic neuron;Drug Regulations;Drug usage;Dynorphins;Experimental Designs;experimental study;Female;Genes;Glean;Harm Reduction;Hour;Individual;insight;Intake;Intravenous;Investigation;Ipsilateral;kappa opioid receptors;knock-down;male;Modeling;neural;neural circuit;neurochemistry;neuromechanism;Neurons;neuroregulation;Nucleus Accumbens;overdose death;overdose risk;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phase;Public Health;Rattus;Receptor Signaling;Regulation;Research;Resolution;Side;Signal Transduction;substance abuser;System;Testing;tool;Training;transcription factor;transmission process;United States;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Neural mechanisms regulating cocaine consumption

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Endoplasmic reticulum (ER) participates in so many cellular tasks that trouble can ensue when it stops working properly, including β cell death in type 1 and type 2 diabetes. Despite the underlying importance of ER dysfunction, there is no effective diabetes treatment targeting the ER due to the complex etiologies of type 1 and type 2 diabetes. Our strategy for overcoming this challenge is to focus on monogenic forms of diabetes in which mutations in single genes are involved in ER dysfunction and disease manifestations. We will carry out molecular genetic studies of five types of ER diabetes to characterize variants using functional assays and bioinformatics and then develop novel treatments targeting the common molecular pathways altered in hereditary ER diabetes.

PI_NAMEs: KHOMTCHOUK, BOHDAN ;URANO, FUMIHIKO  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Beta Cell;Bioinformatics;Biological Assay;Calcium;Cardiovascular Diseases;Cell Death;Cell Line;Cell model;Cell Physiology;Cell Survival;Cells;Cessation of life;Chemicals;Clinical Data;Complex;data ecosystem;Databases;design;Diabetes Mellitus;Disease;disease phenotype;efficacy testing;Endoplasmic Reticulum;endoplasmic reticulum stress;Epilepsy;Etiology;Failure;Functional disorder;Genes;Genetic;Genetic study;genetic variant;genetically modified cells;genomic data;Glucose;Homeostasis;induced pluripotent stem cell;Inherited;INS gene;Insulin;insulin secretion;lipid metabolism;Metabolic Diseases;Microcephaly;Modeling;Modification;Molecular;Molecular Chaperones;Molecular Genetics;mutant;Mutate;Mutation;novel;Organelles;overexpression;oxidation;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phenotype;precision medicine;protein folding;Proteins;Regulation;response;Role;small molecule;Syndrome;Testing;Therapeutic;therapy design;type I and type II diabetes;Variant;WFS1 gene;Wolcott-Rallison syndrome;Wolfram Syndrome

PROJECT_TITLE: Molecular Genetics of Hereditary Endoplasmic Reticulum Diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Tissue repair places many metabolic requirements on the wounded tissue for adequate healing and suffers from the detrimental effects of many pathological conditions. Obesity and diabetes are critical conditions that impair the metabolic regulation of many tissues. This proposal will optimize NAD functions in the metabolism of fracture tissues for the enhancement of bone fracture repair in an obesity/Type-2 diabetic condition. Obesity and the associated condition of Type-2 diabetes have become more frequent in the general population and are even more serious among aging veterans. It is well established that Type-2 diabetics generally suffer from impaired tissue and bone healing caused by an insufficient metabolic response to the requirements of tissue repair. Among the many documented effects of Type-2 diabetes on bone, the critical processes of osteogenesis and vascularity are reduced. Wound healing in challenging physiological conditions such as diabetes and obesity is therefore particularly problematic in bone repair and requires novel approaches that optimize tissue metabolism for healing.  This study will develop novel local therapeutic approaches to improve the tissue redox potential and promote bone repair in an obesity/Type-2 diabetes condition. This intervention will increase NAD production and fracture tissue metabolism through the local application of NAMPT agonists and augment NAMPT functions in the NAD salvage pathway. To achieve these objectives, selected agonists of NAMPT functions will be screened for their action on periosteal cells and identified as therapeutic candidates for the enhancement of NAD biosynthesis. These NAMPT agonists will subsequently be applied locally to the fracture tissues of mice induced to an obesity/Type-2 diabetic through a high-fat diet and bone repair then evaluated.  We have acquired exciting preliminary data demonstrating that local applications of an antagonist of NAMPT inhibits the functions of bone cells in vitro and impairs bone formation in vivo in the fractures of normal mice. It therefore stands to reason that the local application of an agonist of NAMPT functions would produce the opposite effect, enhancing NAD production and tissue metabolism, promoting bone formation in mice with physiologic conditions of reduced tissue metabolism and ultimately enhancing otherwise impaired bone fracture healing. We have chosen the obesity/Type-2 diabetic condition to test our hypothesis that augmenting NAMPT functions through the local application of an NAMPT agonist improves bone formation and fracture repair in an obesity/Type-2 diabetic condition, we hypothesize that NAD production is insufficient to maintain the tissue metabolism necessary for sufficient bone formation and fracture repair.  Two specific aims are proposed to develop this approach. 1) Agonists of NAMPT function will be screened in those bone cells established as mediators of endochondral bone formation, specifically periosteal cells. The effects of these NAMPT agonists on bone cell proliferation, motility and redox potential will be characterized. 2) Candidate NAMPT agonists that are especially potent or multifunctional in the enhancement of these functions in periosteal cells will subsequently be injected directly to the tibial fractures of mice that have been induced to the obesity/Type-2 diabetes condition through a high-fat diet. The effects of these agonists on bone repair in this condition will be characterized by various radiologic and histologic approaches for their promotion of healing. The results will help to develop local therapeutic interventions that improve impaired bone fracture repair.  The completion of the proposed studies should facilitate the development of novel therapeutic interventions that improve tissue responses to the metabolic requirements of wound repair and promote the healing of skeletal and non-skeletal tissues in challenging conditions such as age, obesity and diabetes.

PI_NAMEs: RUNDLE, CHARLES  (contact)

PROJECT_TERMS: Adenosine;Age;Aging;Agonist;Anabolism;Animal Model;antagonist;Blood Vessels;bone;Bone callus;bone cell;Bone Density;bone fracture repair;bone healing;bone repair;Cartilage;cell motility;Cell Physiology;Cell Proliferation;Chronic;Clinical;Clinical Pathology;comorbidity;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;Diabetic mouse;Dinucleoside Phosphates;dosage;Dose;Economics;efficacy testing;Fracture;Future;General Population;healing;Health;High Fat Diet;Histologic;Histology;immune cell infiltrate;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;Inflammation;Injury;Intervention;Longevity;Measurement;Measures;Mediator;Medical;Metabolic;Metabolism;microCT;Motility;mouse model;Mus;NADH;Niacinamide;nicotinamide phosphoribosyltransferase;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;Obesity;Oryctolagus cuniculus;Osteoclasts;Osteogenesis;Overweight;Oxidation-Reduction;Pathologic;Pathway interactions;patient population;Periosteal Cell;pharmacologic;Physiological;Population;Prevalence;Probability;Process;Production;Radiology Specialty;Reactive Oxygen Species;Regulation;repaired;response;Roentgen Rays;Safety;sensor;Signal Pathway;skeletal;small molecule;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;Tibial Fractures;Time;tissue repair;Tissues;Titrations;Type 2 diabetic;United States;Veterans;Wild Type Mouse;wound;wound healing

PROJECT_TITLE: NAMPT regulation of fracture tissue metabolism during bone healing

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Nerve cells (neurons) project elongated processes (axons) from the brain into the spinal cord to make connections (synapses) with motor neurons that drive movement. To identify genes that control the specificity of these connections, we are using the nematode C. elegans, a model organism with a simple, well-defined nervous system. The results of this work should reveal similar human genes with crucial roles in the creation spinal cord circuits and therefore potentially contribute to the development of treatments for spinal cord injury and dysfunction.

PI_NAMEs: MILLER, DAVID M (contact)

PROJECT_TERMS: Address;Adenylate Cyclase;Adopted;Adoption;anterograde transport;ATP phosphohydrolase;Axon;Binding;biochemical model;Biological Assay;Brain;Caenorhabditis elegans;Cells;Chemical Synapse;Cultured Cells;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Electrical Synapse;Exhibits;experimental study;Functional disorder;G-Protein-Coupled Receptors;Gap Junctions;Genes;Genetic;genetic analysis;Genetic Transcription;Homologous Gene;Human;Image;imaging modality;Imaging Techniques;Impairment;in vitro Assay;in vivo;Interneurons;Ions;Kinesin;Learning;live cell imaging;Locomotion;Mammalian Cell;Mediating;member;Methods;Microtubules;model organism;Modeling;Molecular;Motor;Motor Activity;Motor Neurons;Movement;mutant;Nematoda;Nervous System;neuronal cell body;Neurons;Neuropeptide Receptor;novel;optogenetics;Pathway interactions;phosphoric diester hydrolase;Positioning Attribute;preservation;prevent;Process;programs;protein purification;Proteins;Repression;Role;Signal Transduction;single molecule;Specific qualifier value;Specificity;Spinal Cord;Spinal cord injury;Synapses;Testing;therapy development;tool;trafficking;Transcript;transcription factor;transcriptome sequencing;Vesicle;Work

PROJECT_TITLE: Molecular mechanisms for neuron-specific assembly of electrical synapses

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_DEPT: SURGERY

PHR: Narrative Recent studies have suggested that living donors (LDs) have increased risks of kidney failure and death; but follow-up has been limited and there are serious problems with the scientific design of these studies, particularly with the characteristics of people compared to the LDs. We will compare LDs with true long-term follow-up to an optimally matched control group (same time period, same geographic area, healthy on date of donation, no abnormal kidney function); and in addition to kidney failure and death, study intermediate events (e.g., kidney function, cardiovascular disease), pregnancy and outcomes after new-onset disease (e.g., hypertension).

PI_NAMEs: MATAS, ARTHUR J (contact);RULE, ANDREW DAVID

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: adverse outcome;Affect;Age;Algorithms;Area;Birth;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;Cessation of life;Characteristics;Chronic Kidney Failure;Clinic;cohort;Control Groups;County;Creatinine;Data;Data Collection;Data Set;design;Detection;Deterioration;Diabetes Mellitus;Disease;disorder risk;Documentation;Donor person;Electronics;Eligibility Determination;End stage renal failure;Epidemiology;Ethnic Origin;Event;experience;Family history of;Focal and Segmental Glomerulosclerosis;follow-up;Future;Gender;General Population;Geographic Locations;Geography;Government Agencies;Health;Human;Hypertension;Incidence;indexing;Informed Consent;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Link;Living Donors;living kidney donor;Long-Term Effects;Longterm Follow-up;Maintenance;Medical History;Medical Record Linkage;Medical Records;Methods;Minnesota;Modeling;mortality;Nephrectomy;Onset of illness;operation;Outcome;Outcome Study;Patients;Persons;Population;Population Control;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;programs;prospective;Proteinuria;Provider;Published Comment;Qualifying;Race;Rattus;Renal function;Reporting;research clinical testing;Risk;Risk Factors;Selection Bias;Serum;sex;Smoking;Smoking History;Statistical Data Interpretation;surgical risk;System;Time;tool;Transplantation;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Outcomes in living kidney donors over 50 years compared to a healthy matched contemporaneous non-donor cohort from the same geographical region

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The efficacy of psychological interventions for posttraumatic stress disorder (PTSD) is likely limited by the difficulty patients have learning and remembering important therapy content. The proposed research will examine whether integrating a Memory Support intervention into Cognitive Processing Therapy for PTSD improves memory and learning of therapy content as well as corresponding reductions in PTSD symptoms. This work has the potential to advance knowledge about how to optimally deliver treatment for PTSD and help us better understand the factors influencing therapeutic learning.

PI_NAMEs: CARPENTER, JOSEPH KEVIN (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Aftercare;Arousal;Attention;Basic Science;Benchmarking;Boston;Case Series;Clinical;clinical efficacy;Clinical Trials;Cognitive;cognitive function;Cognitive Therapy;Competence;Cues;Data;Data Analyses;design;Development;Dissociation;Distress;education research;Emotional;Exhibits;Expectancy;experience;Extinction;follow-up;Fright;Healthcare Systems;improved;improved outcome;Individual;Intervention;Investigational Therapies;Knowledge;Learning;Memory;Memory impairment;Mental Depression;Mentors;Mentorship;Methodology;Methods;Neurocognitive;novel;novel strategies;Outcome;Participant;Patients;Phase;post intervention;Post-Traumatic Stress Disorders;Protocols documentation;psychologic;Psychotherapy;Randomized, Controlled Trials;recruit;Research;Research Personnel;Resources;response;Retrieval;Safety;satisfaction;Scientific Advances and Accomplishments;Short-Term Memory;skills;Stimulus;Symptoms;Taxes;Techniques;Testing;Therapeutic;therapy development;Training;Trauma;trauma exposure;treatment adherence;Treatment Efficacy;Treatment outcome;treatment response;trial comparing;Validation;verbal;Verbal Learning;Work

PROJECT_TITLE: Enhancing Memory and Learning in Cognitive Processing Therapy for PTSD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Critically ill pediatric patients are at risk for poor outcomes if they do not receive high-quality care by prehospital emergency services, and there is significant concern that the quality and safety of pediatric prehospital care is lacking. In this project, we will develop a method to measure how ready an Emergency Medical Services agency is to care for critically ill pediatric patients. We will then evaluate how the readiness factors are associated with patient outcomes in a large cohort of children from both urban and rural areas across the US.

PI_NAMEs: HANSEN, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: Emergency Medical Services for Children Evaluation of Readiness and Outcomes (EMSC-HERO)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

PHR: PROJECT NARRATIVE  Human cells are challenged constantly by genotoxic stress of both environmental and intracellular origins. The ability to maintain the structure and function of the DNA replication machinery in the face of genotoxic stress is key to the prevention of cancer and other diseases. This proposal seeks to decipher a novel calcium-dependent signaling pathway that is essential for the protection of the replication machinery, with the ultimate goal of developing more effective cancer treatment strategies.

PI_NAMEs: YOU, ZHONGSHENG  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Adaptor Signaling Protein;Address;Aldehydes;AMP-activated protein kinase kinase;Binding;biological adaptation to stress;Biology;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Channel;Calcium Signaling;cancer cell;cancer prevention;cancer therapy;Cell Death;Cell Survival;cell transformation;Cells;Chromosomal Instability;Chromosomal Stability;Chromosome abnormality;CRISPR screen;Cytoprotection;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA replication fork;Drug resistance;Endogenous Factors;Ensure;environmental agent;Foundations;Genetic Diseases;Genetic Induction;Genome;Genome Stability;genome-wide;Genomic Instability;Genotoxic Stress;Goals;Grant;Human;Hypersensitivity;insight;Ion Channel;Maintenance;Malignant Neoplasms;Mediating;Molecular;novel;nuclease;Oncogene Activation;Pathway interactions;Phosphorylation;Premature aging syndrome;Process;protective pathway;Proteins;Reactive Oxygen Species;recruit;Regulation;repaired;replication stress;Replication-Associated Process;Repression;response;Role;sensor;Series;side effect;Signal Pathway;Signal Transduction;Source;Structure;targeted cancer therapy;therapeutic target;treatment strategy

PROJECT_TITLE: Molecular mechanisms of DNA damage signaling and repair

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Primary Health Care

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Our proposal seeks to understand the impact that recently announced changes to the Medicare Shared Savings Program will have on an accountable care organization’s (ACO’s) decision to participate, as well as the potential effects of these changes on care delivery, health outcomes, and spending. Findings from our study will be of value to policymakers and clinician leaders, providing them with actionable insights as they incorporate greater financial risk into the ACO model.

PI_NAMEs: HOLLENBECK, BRENT K. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acceleration;Accountability;accountable care organization;Address;Administrator;Affect;American;Benchmarking;beneficiary;care coordination;care costs;care delivery;Caring;Clinical;Contracts;cost;Cost Control;cost shifting;Data;design;Drops;End stage renal failure;Evaluation;Fee-for-Service Plans;financial incentive;Health;health care quality;health management;Healthcare;high risk;Hospitals;improved;Incentives;Information Systems;innovation;insight;Interview;Location;Measures;Medicare;Medicare claim;mindfulness;Modeling;Motivation;next generation;older patient;optimism;Organizational Models;Outcome;Pathway interactions;Patient Selection;Patients;payment;Performance;Physicians;Policy Maker;Population;population health;Preventive service;Price;Process;programs;Provider;Quality of Care;Rewards;Risk;Sampling;Savings;Standardization;Structure;success;Telephone;United States Centers for Medicare and Medicaid Services;Work

PROJECT_TITLE: Accelerating the Shift to Downside Risk in Medicare Accountable Care Organizations: Effects on Clinical Quality and Costs among Older Patients

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The skin surface is populated by diverse bacteria, and some of these commensal species help protect the skin against pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). Our proposed studies will determine how cell to cell signaling mechanisms are employed by commensal bacteria to enable them to outcompete pathogens and thus benefit skin immunity. This research is relevant to public health because it is expected to provide the basis for the development of new strategies to treat and/or prevent bacterial infections.

PI_NAMEs: GALLO, RICHARD L;HORSWILL, ALEXANDER R (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Animal Model;anti-microbial peptide;Antibiotics;Atopic Dermatitis;Bacteria;Bacterial Infections;Cells;Coagulase;commensal bacteria;Communication;Communities;Culture Media;Data;Development;Disease;Enzymes;Epithelium;exoenzyme;Genetic;Genus staphylococcus;Goals;Growth;Health;Health Promotion;Homeostasis;Human;Immune;Immunity;immunoregulation;improved;In Vitro;Individual;Infection;Inflammation;inhibitor;innovation;insight;Investigation;Knowledge;member;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Modeling;mutant;pathogen;Peptide Hydrolases;Peptide Signal Sequences;Peptides;Phenols;Play;prevent;Production;Proteins;Public Health;Publications;quorum sensing;Regulator Genes;Regulon;Research;resident commensals;Resources;Role;Signal Transduction;Skin;skin barrier;Skin colonization;skin damage;skin disorder;skin microbiome;staphylococcal protease;Staphylococcus aureus;Staphylococcus epidermidis;Staphylococcus haemolyticus;Staphylococcus hominis;Stratum corneum;Structure;Surface;synthetic peptide;System;Testing;Tissues;Toxin;transcriptome sequencing;Work

PROJECT_TITLE: Quorum sensing, diversity and skin inflammation


ORG_CITY: DALLAS

ORG_DEPT: GENETICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  This project is proposed to study a novel mechanism regulating transmembrane proteins by inverting the direction through which they are inserted into membranes. Achieving the project will have significant impacts on basic science regarding structure and function of transmembrane proteins, as it will fundamentally change our views on these proteins. Since transmembrane proteins are often the receptors for various drugs and pathogens, completion of the project may provide novel insights to combat human diseases.

PI_NAMEs: YE, JIN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adopted;Basic Science;CCR5 gene;Ceramides;combat;Data;human disease;improved;insight;Integral Membrane Protein;Mammalian Cell;Measures;Mediating;Membrane;novel;pathogen;Pharmaceutical Preparations;Physiological;Process;Protein Biosynthesis;Protein translocation;Proteins;Proteome;Reaction;receptor;Regulation;Reporting;Ribosomes;sensor;Signal Transduction;Sphingolipids;Structure;Testing;Translations

PROJECT_TITLE: Topological regulation of transmembrane proteins through Regulated Alternative Translocation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Biotechnology;Microbiome

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Narrative: This proposal deals with two issues in bioanalysis. We will first develop a novel and powerful tool for characterization of the microbiome. The technology developed in this grant will have obvious application in diseases of the gut. The second technology under development is to improve high sensitivity proteomic analysis, which will have applications whenever minute samples are to be analyzed, such as fine needle biopsies.

PI_NAMEs: DOVICHI, NORMAN J (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Aliquot;Blood capillaries;Complex;contig;Coupled;Culture-independent methods;Data;Data Set;Development;Disease;Electrophoresis;Embryo;embryo stage 2;Fine-needle biopsy;Fractionation;Funding;Genes;Genome;Goals;Grant;improved;Maps;mass spectrometer;Metagenomics;Methods;microbial community;microbiome;microbiome analysis;next generation sequencing;novel;Organism;Paper;parallel processing;Peptides;Preparation;Process;Protein Analysis;Proteins;Proteomics;Publishing;Reagent;Recovery;Sampling;segregation;System;Technology;tool;Work;Xenopus laevis

PROJECT_TITLE: Advances in bioanalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE In less developed parts of the world, there is an urgent need for accurate and more informative diagnosis of breast cancer as trained pathologists are scarce‚ and pathology infrastructure is often very limited. The proposed research will complete the currently ongoing development of a cell-phone based device that: (1) images cells from breast tumors and analyzes them by software to identify whether a person has breast cancer, and (2) measures levels of clinically-relevant protein biomarkers to help guide treatment. If successful, this technology can be widely by health care workers to provide the same level of care in low-resource settings as is currently available in the US and will thereby save many lives.

PI_NAMEs: CHILKOTI, ASHUTOSH  (contact);HWANG, E. SHELLEY

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Academic Medical Centers;accurate diagnosis;Address;Africa;algorithm training;Antibodies;aspirate;Automobile Driving;Biological Assay;Biological Markers;Breast;Breast biopsy;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Patient;breast cancer survival;Breast Cancer Treatment;breast pathology;cancer cell;cancer diagnosis;Cancer Etiology;cancer subtypes;Caring;Cells;cellular imaging;Cellular Morphology;cellular pathology;Cellular Phone;Cessation of life;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;cloud platform;Computer software;Core Biopsy;Correlation Studies;cost;Country;Cytology;Cytopathology;Data;data repository;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;disorder subtype;Epidermal Growth Factor Receptor;Estrogen Receptors;Evaluation;Fine needle aspiration biopsy;Health Personnel;Health Services Accessibility;Histology;Histopathology;Human;Image;Imaging Device;Immunodiagnostics;Immunohistochemistry;improved;improved outcome;industry partner;Infrastructure;innovation;Intervention;Investigation;Life;machine learning algorithm;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Medical center;Methods;mobile computing;Modification;Molecular;molecular marker;molecular pathology;Molecular Profiling;Mus;Needles;North Carolina;Operative Surgical Procedures;Outcome;Pathologic;Pathological Staging;Pathologist;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;Pilot Projects;point of care;point of care testing;Population;pre-clinical;preclinical study;Progesterone Receptors;Prognosis;Proliferating;protein biomarkers;prototype;rapid diagnosis;Research;Research Personnel;Resource-limited setting;Resources;response;Sampling;Selection for Treatments;Sensitivity and Specificity;Services;smartphone application;smartphone based device;Specimen;subtype-specific therapies;Tanzania;Technology;Telemedicine;Testing;Training;Training and Infrastructure;Translating;Translations;treatment planning;tumor;Tumor Markers;Tumor Subtype;Universities;usability;user-friendly;Validation;virtual;Visit;wireless transmission;Woman;Women's mortality

PROJECT_TITLE: Point-of-care cellular and molecular pathology of breast tumors on a cell phone


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Childhood Injury;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

PHR: I have spent my career as an NINDS-funded neuroscientist developing expertise in neuronal ion homeostasis and translating my findings to clinical care. Although I have focused on seizure therapies, many of the discoveries I have made are equally applicable to the volume shifts that occur in neurons after brain injury. These volume shifts are among the most incalcitrant and problematic barriers to improved outcomes after brain injury. In the enclosed R35 application, I propose to leverage NINDS’ investment in me and unravel these problems.

PI_NAMEs: STALEY, KEVIN J. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute Brain Injuries;Anions;Atrophic;bench-to-bedside translation;Blood Vessels;Brain;Brain Edema;Brain Injuries;career;Caring;Cell Membrane Permeability;Chlorides;clinical care;cytotoxic;Edema;Epileptogenesis;Equilibrium;extracellular;fluorophore;Funding;gamma-Aminobutyric Acid;Hemorrhage;Homeostasis;Image;Imaging Techniques;improved outcome;In Vitro;in vivo;Injury;insight;Investments;Ions;macromolecule;Magnetic Resonance Imaging;Membrane;National Institute of Neurological Disorders and Stroke;neonatal seizure;Neuronal Injury;Neurons;novel therapeutic intervention;novel therapeutics;Osmosis;premature;Receptor Signaling;Regulation;Seizures;Side;Signal Transduction;Stretching;Tissues;Translating;Translations;ultrasound;Very Low Birth Weight Infant

PROJECT_TITLE: Neuronal Ion and Volume Shifts After Acute Brain Injury


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Urologic Diseases

PHR: NARRATIVE: Uropathogenic E. coli (UPEC) has been shown to reside within the gastrointestinal tract (GIT) as an asymptomatic reservoir capable of seeding recurrent urinary tract infections (rUTI). This proposal seeks to elucidate how the previously unexplored interplay between the GIT and bladder (the gut-bladder axis) determines susceptibility to rUTI by determining: i) genetic mechanisms used by UPEC to invade, persist, and bloom in the GIT; ii) how the microbiota elicits host responses linked to susceptibility to rUTIs; and iii) how dysbiosis of the GIT microbiota affects colonization resistance. Knowledge gained by these studies will transform the development of antibiotic-sparing therapeutics needed to treat and prevent recurrent UTIs.

PI_NAMEs: EARL, ASHLEE MIRIAM;HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Bacteria;Bladder;Chronic;Clinical;cohort;Collection;colonization resistance;comparative genomics;Data;Deterioration;Development;Digestive System Disorders;Distal;Dose;Drug resistance;dysbiosis;economic impact;Epidemiology;Escherichia coli;Event;experience;Feces;Female;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;Genomics;Gnotobiotic;Goals;gut colonization;Habitats;Health Care Costs;Homeostasis;Human;humanized mouse;immune function;Immune response;Immune system;Immunologic Markers;Immunologics;Impairment;indexing;Individual;Infection;Inflammation;Inflammatory;Invaded;Investigation;Knowledge;Link;longitudinal analysis;Measures;Mediator;Metagenomics;metatranscriptomics;Methods;microbiota;microorganism;Molecular;Molecular Profiling;Morbidity - disease rate;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Mutagenesis;new technology;novel;Organ;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pattern;Physicians;Pilum;Predisposition;Prevalence;prevent;Process;Quality of life;Recurrence;Research;residence;Resolution;Risk;Role;Sampling;stool sample;Streptomycin;Structure;Technology;Testing;Text;Therapeutic;therapeutic development;therapy development;Time;Tissues;transcriptomics;United States;urinary;Urinary tract;Urinary tract infection;Urine;Urologist;Uropathogenic E. coli;Woman;women's diagnosis

PROJECT_TITLE: Epidemiologic and molecular basis of the gut-urinary tract axis in urinary tract infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Among critically ill patients with acute kidney injury and treated with dialysis in the intensive care unit, if one could accurately predict early which patients will develop low blood pressure then effective treatments could be given. In this study, we propose to develop and validate an artificial intelligence system that will predict low blood pressure even before they occur and recommend correct treatment to clinicians.

PI_NAMEs: CLERMONT, GILLES ;KASHANI, KIANOUSH B;MURUGAN, RAGHAVAN  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;adjudication;Algorithms;Animals;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;Cessation of life;Clinic;Clinical;clinically relevant;Critical Illness;Data;data modeling;Dependence;design;Dialysis procedure;Early Diagnosis;effective therapy;effectiveness validation;Electronic Health Record;Event;Excision;Expert Opinion;Expert Systems;Frequencies;Future;Health system;Healthcare Systems;hemodynamics;Hemorrhage;Hemorrhagic Shock;Hospital Mortality;Hospitals;Hour;Human;Hypotension;Hypovolemia;Hypovolemics;improved outcome;Intensive Care Units;Intervention;Lead;Learning;learning algorithm;learning strategy;Link;Liquid substance;machine learning model;Measurement;Medical center;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Observational Study;organ injury;Outcome;outcome prediction;Patient Monitoring;Patients;Performance;personalized intervention;personalized risk prediction;porcine model;predicting response;Predictive Analytics;prevent;Probability;prospective;Psychological reinforcement;randomized, clinical trials;Reaction;Recommendation;Recovery;Refractory;Renal function;Renal Replacement Therapy;Resolution;Resources;response;Resuscitation;Risk;risk prediction;Risk Reduction;Structure;System;Testing;Time;Titrations;Training;Universities;usability;Validation;Vasoconstrictor Agents;Work

PROJECT_TITLE: AI driven acute renal replacement therapy - (AID-ART)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Obesity

PHR: Project Narrative Diabetes and associated diseases are major health concerns in today’s society. The proposed research is relevant to the mission of the NIDDK because it provides mechanistic and pathophysiological insight into a novel mechano-signaling pathway that regulates skeletal muscle function and metabolism. Delineating this pathway will expand our knowledge base in skeletal muscle physiology and may provide an innovative therapeutic target for the treatment and prevention of diabetes.

PI_NAMEs: SAH, RAJAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipocytes;Adrenal Cortex Hormones;Aerobic;Aging;aging population;Amino Acids;Anions;arm;Biochemical;Biogenesis;Cachexia;Cell membrane;Chronic;Complex;CRISPR screen;CRISPR/Cas technology;Data;defined contribution;Denervation;detection of nutrient;Diabetes Mellitus;Diabetes prevention;Disease;Disuse Atrophy;Equilibrium;exercise capacity;experimental study;Fiber;Fluorescence Microscopy;FRAP1 gene;Gene Expression;Generations;Genes;Genetic Transcription;GLUT 4 protein;Growth;growth factor receptor-bound protein 2;Health;Heart Diseases;Heart failure;Histologic;Hour;Human;Hypertrophy;Image;Immunoprecipitation;In Vitro;in vivo;innovation;insight;Insulin;Ion Channel;Knock-in Mouse;Knock-out;knowledge base;Label;Laboratories;Leucine;Lysosomes;Maintenance;Malignant Neoplasms;Measures;Mediating;Metabolic;Mission;Mitochondria;Modeling;Molecular;mortality;mTOR Signaling Pathway;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;muscle metabolism;muscle physiology;mutant;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nutrient;Obesity;Obesity associated disease;obesity prevention;Osmosis;overexpression;Paralysed;patch clamp;Pathway interactions;PIK3CG gene;Proto-Oncogene Proteins c-akt;Protons;Publishing;Reagent;Recovery;Regulation;Research;response;Role;Signal Transduction;Skeletal Muscle;skeletal muscle growth;skeletal muscle wasting;Societies;Soleus Muscle;Stretching;superresolution microscopy;Swelling;Techniques;Testing;therapeutic target;Tissues;Training;treadmill;treadmill training;uptake;vacuolar H+-ATPase

PROJECT_TITLE: SWELL1-LRRC8 mediated regulation of skeletal muscle function and metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE  As the most common childhood-onset motor disability, cerebral palsy (CP) affects 764,000 individuals in the United States alone and accounts for lifetime healthcare expenses of $1.4 million per person. In approximately 20% of cases (or 150,000 individuals), the cause is unknown, raising concern for a genetic disorder, including treatable conditions where a molecular diagnosis may positively alter the trajectory of a child's development. This study will determine the genetic landscape of CP, including potentially treatable conditions; develop rules to predict which individuals with CP are likely to have a genetic disorder; and contribute to an emerging scientific understanding of the pathophysiology of CP that will impact a large patient population.

PI_NAMEs: SRIVASTAVA, SIDDHARTH  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Ataxia;Attention;Biological;Boston;career development;Cerebral Palsy;Characteristics;Child;Child Development;Childhood;Chorea;Classification;Classification Scheme;Clinical;clinical practice;cohort;Communication;comorbidity;Data;Development;Diagnostic;Disease;disease-causing mutation;Dystonia;economic impact;Enrollment;Etiology;exome;exome sequencing;Face;Functional disorder;Future;Genes;Genetic;genetic analysis;Genetic Diseases;genetic disorder diagnosis;genetic testing;Genomics;Goals;health economics;Healthcare;Hospitals;Image;Inborn Errors of Metabolism;Individual;Institution;instrument;intrauterine infection;Knowledge;Magnetic Resonance Imaging;Measures;Medical;Medical Care Costs;Mendelian disorder;Molecular Diagnosis;Motor;Motor disability;neonatal hypoxic-ischemic brain injury;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurodevelopmental Impairment;neuroimaging;Neurologic;Participant;Pathogenicity;patient population;Patients;Pattern;Perinatal;Persons;Phenotype;Pilot Projects;Population;Precision therapeutics;Predictive Factor;premature;Prevalence;prospective;Prospective cohort;Rare Diseases;Reproducibility;Research;Risk Factors;Role;Scientist;Severities;spasticity;Statistical Models;Subgroup;Symptoms;Therapeutic;Training;United States;Variant;Work

PROJECT_TITLE: Investigating the Genetic Landscape of Cerebral Palsy


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The primary objective of the proposed alcohol research training program is to increase the availability of skilled clinical scientists from diverse backgrounds. We will achieve this goal by providing individual and group didactics and mentorship during the critical transition from clinical psychology doctoral training through clinical internship and NIAAA-supported postdoctoral fellowships. Implementing the proposed training program will help ensure that NIAAA remains a global leader in the development and dissemination of effective alcohol-related prevention and treatment efforts, and that it is equipped to fulfill its mission to meet the continuously evolving healthcare needs of the U.S. population.

PI_NAMEs: FLANAGAN, JULIANNE CHRISTINA (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Acceleration;Address;Advisory Committees;alcohol research;alcohol use disorder;Alcoholism;Alcohols;Area;Awareness;Behavior;Behavior Therapy;career;Career Choice;Clinical;Clinical Psychology;Clinical Skills;cohort;Combined Modality Therapy;Country;Creativeness;Cultural Sensitivity;Data;Dedications;Development;disability;Disability status;Disparity;Dissemination and Implementation;Doctor of Philosophy;Education;education research;educational atmosphere;Ensure;ethnic diversity;Ethnic Population;Evaluation;evidence base;Expenditure;experience;Face;faculty mentor;Feedback;Feeling;Fellowship;Fellowship Program;Financial Hardship;Financial Support;Funding;Goals;graduate student;Grant;health disparity;Healthcare;implicit bias;improved;Individual;innovation;insight;interest;Internships;Interview;Leadership;meetings;member;Mentors;Mentorship;Minority Groups;minority trainee;Mission;National Institute on Alcohol Abuse and Alcoholism;next generation;novel;Participant;Patient Care;peer;peer coaching;Pharmacological Treatment;Population;post-doctoral training;Postdoctoral Fellow;pre-doctoral;pressure;Prevention;Process;Productivity;Program Evaluation;Program Sustainability;programs;prospective;Psychologist;Psychology;Public Health;Qualifying;racial minority population;racial population;recruit;Reporting;Research;Research Personnel;research study;Research Training;response;Scientific Advances and Accomplishments;Scientist;Self Efficacy;skill acquisition;skills;Societies;socioeconomic disadvantage;socioeconomic disparity;Strategic Planning;Structure;Substance abuse problem;Substance Addiction;Talents;Time;Training;training opportunity;Training Programs;Translations;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;working group;Writing

PROJECT_TITLE: Preparing Trainees from Diverse Backgrounds for Alcohol Research Careers


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative: We are studying the physical and mechanistic principles that underlie protein function. The coupling of enzyme motions to active site chemistry is being interrogated, as are novel enzyme activities that produce ribosomally- synthesized, post-translationally modified products.

PI_NAMEs: KLINMAN, JUDITH P (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Address;Antibiotics;Area;Biochemical;Biological;Catalysis;catalyst;Chemistry;cofactor;Coupling;design;Development;Drug Targeting;enzyme activity;enzyme mechanism;enzyme structure;Enzymes;Event;Family;Hand;Human;Hydrogen;Knowledge;Methodology;Motion;novel;novel strategies;Pathway interactions;Peptides;Post-Translational Protein Processing;PQQ Cofactor;Property;protein function;Proteins;prototype;Reaction;Ribosomes;temporal measurement;Vitamins

PROJECT_TITLE: Looking in New Directions for Origins and Cryptic Mechanisms of Enzyme Catalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Multiple sclerosis (MS) is a debilitating incurable disease and presents a major public health problem leading to great economic and societal burden. The proposed studies will determine the capabilities of neural stem cells derived from primitive mesenchymal stem cells to provide anti-inflammatory response and neuroprotection as well as neuroregeneration in an animal model of MS. The results of this investigation will help devise strategies to treat not only MS but also other neurodegenerative disorders using cell therapies.

PI_NAMEs: CHAUDHRY, G. RASUL (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adult;Affect;Aging;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;astrogliosis;Blood;Brain-Derived Neurotrophic Factor;CASP3 gene;Caspase;Cell Death;Cell Therapy;Cell Transplantation;Cells;Central Nervous System;central nervous system demyelinating disorder;Chronic;Clinical;Code;Complex;cytokine;Data;Degenerative Disorder;Demyelinations;Differentiation and Growth;Disease;Disease Progression;Disease remission;Dose;Drug usage;Economics;embryonic stem cell;Engraftment;environmental stressor;Enzyme-Linked Immunosorbent Assay;Ethics;Exhibits;Experimental Autoimmune Encephalomyelitis;Face;Fast Blue;Gene Expression;Generations;Genetic;glial cell-line derived neurotrophic factor;Glial Fibrillary Acidic Protein;Gliosis;Goals;Homing;Human;Immune;immune cell infiltrate;Immune response;Immunization;immunoregulation;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Investigation;Label;Lesion;Life;Lung;Mechanics;Mesenchymal Stem Cells;Modeling;Molecular;Monitor;Motor;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;Myelin Proteins;myelination;Nerve Degeneration;Nerve Regeneration;nerve stem cell;Nervous System Physiology;neurobehavioral;Neurodegenerative Disorders;neurogenesis;Neuroglia;Neurologic;Neurons;neuroprotection;neurotrophic factor;Nuclear Antigens;Older Population;Oligodendroglia;Organ;Pathology;post-transplant;Property;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;Recovery of Function;Regulatory T-Lymphocyte;Research;response;Role;self-renewal;side effect;Signal Pathway;Spinal Cord;Spleen;Stains;stem cell therapy;Stem cell transplant;success;Symptoms;Techniques;Teratoma;Testing;Therapeutic Effect;Time;Tissues;transcriptome;transcriptome sequencing;Transplantation;Western Blotting

PROJECT_TITLE: Efficacy of NSCs in an EAE model of MS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE Following intercourse, the best sperm is naturally selected as the one that first successfully traverses the distinct biochemical microenvironments within the female reproductive tract. By mimicking these diverse biochemical microenvironments within the female reproductive tract and understanding how sperm motility should be accordingly modified, we can help clinicians identify the best sperm for IVF. This will increase production of healthy embryos and thus reduce the number of costly IVF cycles, easing the financial burden and making these procedures more accessible to low-income couples.

PI_NAMEs: GEYER, CHRISTOPHER BENNETT (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acrosome Reaction;Amino Acids;Assisted Reproductive Technology;Biochemical;Bioenergetics;Birth;blastocyst;Chemotaxis;Clinical;cofactor;Competence;Computer Assisted;cost;Couples;Coupling;Data;Development;DNA;DNA Damage;Embryo;Energy-Generating Resources;Environment;Exhibits;experience;Exposure to;Family;family burden;female reproductive tract;Fertilization;Fertilization in Vitro;Financial Hardship;gain of function;Germ Cells;Glycolysis;Household;Human;Hyperactivity;In Vitro;in vitro testing;Income;inhibitor;innovation;insight;Intracytoplasmic Sperm Injections;Ions;Knowledge;loss of function;Low income;lower income families;Metabolic;metabolic phenotype;Metabolism;method development;Methods;Morphology;Motility;Mus;NADH;Natural Selections;novel;oocyte quality;Oxidation-Reduction;oxidative damage;Oxidative Phosphorylation;Oxidoreductase;Pattern;Phenotype;Procedures;Process;Production;Respiration;response;Signal Transduction;sperm cell;sperm function;Sperm Motility;sperm quality;stem;success;sugar;Techniques;Testing;trait;Tyrosine Phosphorylation

PROJECT_TITLE: Selecting sperm with distinct metabolic phenotypes to increase ART efficiency

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative Research using the amphibian Xenopus, because of unique advantages as an experimental system, has revealed key insights in many domains of biomedical research, including cell biology, development, neurobiology, physiology and signal transduction, achievements that are supported by having a centralized National Xenopus Resource for raising and distributing animals and disseminating the most current technology to the research community. In each of these areas research has led to significant insights about the causes of human diseases, including cancer, birth defects, diabetes and neurological disease, and provided key underpinnings for the field of regenerative medicine.

PI_NAMEs: HORB, MARKO E (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Achievement;Address;Amphibia;animal care;Animal Housing;animal resource;Animals;Applied Research;Area;Back;Bioinformatics;Biological;Biological Models;biological research;Biomedical Research;Breeding;Cellular biology;college;Communities;community-centered;Complex;Congenital Abnormality;Custom;Development;Diabetes Mellitus;DNA Sequence Alteration;Educational process of instructing;Educational workshop;Fertilization in Vitro;Funding;Genes;genome editing;Goals;Grant;human disease;Image;Inbreeding;Individual;insight;integration site;Laboratories;Maintenance;male;Malignant Neoplasms;Maps;marine;meetings;Methods;mutant;Nervous System Disorder;Neurobiology;new technology;novel;pathogen;Physiology;Productivity;Rana;Regenerative Medicine;repository;Research;research facility;Research Personnel;Resources;Scientist;Services;Signal Transduction;Site;sperm cryopreservation;System;Techniques;Technology;Training;training opportunity;Transgenes;Transgenic Animals;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Universities;Veterinarians;Visit;Work;XenBase;Xenopus;Xenopus laevis

PROJECT_TITLE: National Xenopus Resource Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D(50)R]


PROJECT_TERMS: animal care;Animal Housing;animal resource;Animals;Back;Bioinformatics;Biological;Breeding;Communities;Custom;Educational process of instructing;Educational workshop;Fertilization in Vitro;Gene Transfer Techniques;genome editing;Goals;Grant;Housing;Image;Inbreeding;Individual;Infrastructure;Institution;Laboratories;Maintenance;male;marine;meetings;mutant;new technology;novel;pathogen;Progress Reports;Rana;repository;Research;research facility;Research Personnel;Resources;Scientist;Services;Site;sperm cryopreservation;Technology;Training;training opportunity;Transgenic Organisms;United States National Institutes of Health;Veterinarians;Visit;XenBase;Xenopus;Xenopus laevis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: This proposal describes the development and optimization of CD46 targeted radioimmunotherapy, and the systematic testing and evaluation of the method in preclinical models of prostate cancer. Novel chemical methodology is utilized to optimize the delivery of therapeutic radiation to tumor while minimizing healthy tissue delivery. A major focus of the proposal is the utilization of novel, clinically relevant metastatic PCa models, and the evaluation of the therapeutic efficacy and toxicity using a combination of histologic, microscale dosimetry, and metabolomic analysis.

PI_NAMEs: FLAVELL, ROBERT RICHARD (contact);SEO, YOUNGHO ;SRIRAM, RENUKA

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Address;animal model development;Antibodies;Antibody-drug conjugates;Antigens;Binding;Biodistribution;Biological;Biological Models;bone;Cancer Model;CD46 Antigen;Chelating Agents;Chemicals;Chemistry;Clinic;Clinical;clinical development;Clinical Trials;clinically relevant;Data;Development;Discipline of Nuclear Medicine;Disseminated Malignant Neoplasm;dosimetry;drug development;effective therapy;efficacy evaluation;efficacy testing;Epitopes;Evaluation;evaluation/testing;flexibility;Future;Goals;Histologic;Histology;Human;human disease;Image;ImmunoPET;immunosuppressed;Implant;In Vitro;innovation;Label;Liver;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;metabolomics;Metastatic Prostate Cancer;Methodology;Methods;Modeling;Monitor;multidisciplinary;Multiple Myeloma;Mus;Normal tissue morphology;novel;Organ;Pathologic;Pathologist;patient derived xenograft model;Pharmacologic Substance;Phase I Clinical Trials;Physicians;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;prostate cancer model;Prostate Cancer therapy;Proteins;Publications;Radiation;Radioimmunotherapy;Radiolabeled;radioligand;Radiopharmaceuticals;Research Personnel;Resistance;Specialist;subcutaneous;Testing;Therapeutic;therapeutic evaluation;Tissues;tool;Toxic effect;treatment effect;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment response;Treatment-related toxicity;tumor;tumor metabolism;tumor progression;Xenograft procedure

PROJECT_TITLE: Systematic evaluation of toxicity and therapeutic efficacy in CD46 directed radioligand therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-R(56)R]


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: Animal Housing;Animals;Applied Research;Bioinformatics;Code;Communities;Custom;DNA Sequence Alteration;Educational process of instructing;Educational workshop;Ensure;Genes;genome editing;Grant;Image;Individual;integration site;Light;Maps;meetings;Methods;Mus;mutant;Mutation;repository;Reproducibility;Research;research facility;Research Personnel;Resources;Sales;Services;Site;Technology;Transgenes;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Work;XenBase;Xenopus


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Nutrition

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Over the past 45 years, the NIDDK-supported training program in the Division of Nutritional Sciences has been instrumental in the development of nutrition professionals who hold research positions in academia, government, and industry, and key policy positions in government, international agencies, and nonprofit foundations. The training program is built on the graduate program in nutrition at Cornell University that emphasizes multidisciplinary and integrative scholarship across the biological, physical, behavioral,and social sciences, as appropriate for individual trainees. The NIDDK-supported training program emphasizes translational and collaborative approaches to meet national needs in translational research and includes a combined PhD-RD training program.

PI_NAMEs: CASSANO, PATRICIA A (contact);QIAN, SHU-BING

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: nutrition;Training

PROJECT_TITLE: NUTRITION TRAINING


ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Inflammation-induced endothelial dysfunction can cause immune diseases, such as chronic inflammation and autoimmune disease. We will establish a nanopatterned inter-digitated electrode arrays-based assay for high- throughput phenotype screening of endothelial cell junction and immune cell interactions in a coculture of endothelial cells and pericytes. With the platform, we will evaluate endothelial dysfunction in inflammation and identify drug candidates to reverse the dysfunction.

PI_NAMEs: KIM, DEOK-HO ;LEE, ESAK  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Address;Adherens Junction;Animal Genetics;Animal Model;Animals;Autoimmune Diseases;Basement membrane;Biological Assay;Biology;Blood;Blood - brain barrier anatomy;Blood Vessels;Categories;Cell Adhesion;cell behavior;Cell Communication;cell motility;Cell-Cell Adhesion;Cells;Cellular Morphology;Chronic;clinically relevant;Coagulation Process;Coculture Techniques;Communicable Diseases;COVID-19;cytokine;Deposition;Dermal;Disease;drug candidate;Drug Screening;electric impedance;Electrical Resistance;Electrodes;Endothelial Cells;endothelial dysfunction;Endothelium;Epithelium;experience;Experimental Models;Extravasation;Functional disorder;Gene Expression;Gene Expression Profile;glomerular filtration;Goals;high throughput screening;Human;Immune;Immune System Diseases;Immunity;Immunology;Impairment;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;Intercellular Junctions;interstitial;Investigation;knock-down;Lesion;Lung;lung microvascular endothelial cells;Lupus;Lymphatic;Measurement;Measures;Mediating;Methods;migration;Modeling;nanopattern;Nature;novel;pathogen;Pattern;Pericytes;Permeability;personalized medicine;Pharmaceutical Preparations;Phenotype;Physiological;Play;polarized cell;prevent;Process;Rapid screening;Reading;Role;screening;Screening procedure;Sepsis;Signal Transduction;Site;Skin;System;Systems Analysis;Technology;Therapeutic;Time;trafficking;Vascular Diseases;Vascular Permeabilities

PROJECT_TITLE: High-throughput nanoIEA-based Assay for Screening Immune Cell-Vascular Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative/Relevance to Public Health: Patients in the early stages of Alzheimer’s disease each display a unique pattern of altered brain structure, function, and thinking and memory skills. Knowing that their diagnosis of amnestic mild cognitive impairment (aMCI) places them at risk for developing Alzheimer’s disease, patients often seek out intervention to delay the progression of the disease without knowing whether it will truly provide benefit. This project will use advanced machine learning tools to provide detailed predictions of aMCI patients’ likelihood of improving from a widely supported cognitive training intervention, and clarify how an individual patient’s brain and cognitive features contribute to their response-to- intervention.

PI_NAMEs: GULLETT, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Alzheimer's Disease;Alzheimer's disease risk;amnestic mild cognitive impairment;Analysis of Variance;Artificial Intelligence;Attention;Behavior Therapy;behavioral clinical trial;Biometry;Brain;Brain region;career;career development;Characteristics;Clinical;clinical translation;Clinical Trials;Cognitive;Cognitive aging;cognitive performance;Cognitive Therapy;cognitive training;cohort;comparison control;Complex;Control Groups;Data;Data Set;Decision Making;design;Diagnosis;Disease;Disease Progression;Educational Intervention;Educational workshop;Effectiveness;executive function;experience;Florida;Foundations;Functional Magnetic Resonance Imaging;Future;gray matter;group intervention;Healthcare;high risk;Home;Impairment;improved;Individual;individual patient;Infrastructure;innovation;Intervention;Intervention Trial;Investigation;Investigative Techniques;Life;Logistic Regressions;Machine Learning;machine learning model;Magnetic Resonance Imaging;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;mild cognitive impairment;Modeling;multimodal neuroimaging;neural;Neuroanatomy;Neurobiology;Neurocognitive;Neurodegenerative Disorders;neuroimaging;Neurosciences;normal aging;older adult;Outcome;Patients;Pattern;payment;Performance;personalized intervention;personalized medicine;Persons;Population;Populations at Risk;predicting response;Predictive Factor;predictive modeling;Prefrontal Cortex;processing speed;professor;Proxy;Public Health;Quality of life;random forest;recruit;Research;Research Personnel;Resources;responders and non-responders;response;Rest;Risk;Sample Size;Sampling;Science;Short-Term Memory;skills;Structure;Superior temporal gyrus;support vector machine;Techniques;Thinking;tool;Training;Training and Education;Training Programs;treatment effect;Universities;vector;white matter;Work

PROJECT_TITLE: Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Heavy drinking in young adults is associated with serious negative consequences and is a major public health concern; however, interventions have shown limited efficacy. The goal of this project is to evaluate cognitive- based and mindfulness-based Regulation of Craving Training (ROC-T), which are novel, brief, web-based interventions that directly target core mechanisms implicated in drinking: craving and the regulation of craving. We specifically propose a randomized-controlled trial comparing these interventions to a control condition, and to test the effects on drinking as well as on cognitive, affective, and neural mechanisms.

PI_NAMEs: KOBER, HEDY  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;addiction;Affective;Age;Alcohol consumption;alcohol cue;alcohol exposure;alcohol risk;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Back;Behavioral Mechanisms;Brain region;cigarette smoking;Clinical Trials;Cognitive;cognitive control;Cognitive Therapy;Communities;comparison intervention;computerized;craving;Cues;Data;Development;drinking;Drug usage;DSM-V;efficacy evaluation;Energy Intake;Exhibits;experience;Exposure to;Food;Functional Magnetic Resonance Imaging;Gender;Goals;Heavy Drinking;Image;improved;indexing;Individual Differences;innovation;Internet;Intervention;Judgment;Link;Measurement;Measures;Meta-Analysis;mindfulness;Mindfulness Training;Modeling;mortality;Motivation;neural;neurobiological mechanism;Neurobiology;Neurocognitive;neuromechanism;novel;Online Systems;Outcome;Participant;Patient Self-Report;Pharmaceutical Preparations;Prefrontal Cortex;prospective;psychologic;Public Health;Randomized;Randomized, Controlled Trials;recruit;Regulation;Relapse;Research;Rewards;Self Assessment;sensor;skills;skills training;Testing;Time;timeline;Training;Treatment outcome;treatment strategy;trial comparing;Ventral Striatum;wearable device;web-based intervention;Work;young adult

PROJECT_TITLE: Regulation of Craving: Clinical Trial and Neural Mechanisms

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Conception failure and miscarriage affect millions of U.S. couples each year. This research uses new georeferenced data on pre-pregnancy and early pregnancy for 4 million U.S. women to provide the first evidence on individual, family, ecological, and policy factors that reduce the risk of early pregnancy failure.

PI_NAMEs: DURRANCE, CHRISTINE PIETTE (contact);NOBLES, JENNA E.

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Affect;Age;Behavior;Biological Markers;Characteristics;Child Mortality;Clinic;clinical practice;cohort;Communities;Conceptions;County;Couples;Data;Data Reporting;Data Science;data tools;design;Devices;digital;Disparate;Disparity;early pregnancy;Economic Conditions;economic cost;Economics;Education;Emotional;Environment;Environmental Exposure;Environmental Risk Factor;Event;experience;Failure;Family;Fertility;Fertility Study;field study;Health;Health behavior;health disparity;Health Policy;Human;Implant;improved;Income;Individual;Infant Mortality;Inflammation;Live Birth;machine learning prediction algorithm;male;Maternal Health;Measures;Medicaid;men;Menstrual cycle;mortality;Neighborhoods;Obesity;Outcome;Ovulation;Pathway interactions;Policies;Policy Analysis;Population;Population Dynamics;population health;Poverty;Pregnancy;pregnancy failure;pregnancy health;Pregnancy loss;Pregnancy Outcome;pregnant;prepregnancy;Prevention;Probability;Process;programs;Public Health;Quasi-experiment;Race;recruit;Reporting;reproductive;Research;Risk;Risk Reduction;Rural Community;Sample Size;Sampling;Science;Shapes;Smoking;social;Social Conditions;social factors;Social Sciences;spatiotemporal;Spontaneous abortion;Statutes and Laws;stillbirth;Stratification;stress reactivity;success;Time;Translations;tribal lands;trying to conceive;Validation;Variant;Weight;Woman;Women's Health

PROJECT_TITLE: Conception Failure and Pregnancy Loss in the U.S.

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: As obesity increases in adolescents type 2 diabetes is also increasing. We do not know why T2D happens in some adolescents but not others or how to identify which adolescents will develop diabetes. This multicenter clinical study is designed to follow a large group of youth at-risk for T2D over 30 months and to identify differences in a variety of factors between those who do and do not develop diabetes.

PI_NAMEs: ENELI, IHUOMA U;HOFFMAN, ROBERT PAUL (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Adolescent obesity;Adult;adverse childhood events;Age;aged;American;Area;B-Lymphocytes;Behavior;Beta Cell;Blood specimen;Body mass index;Body System;C-Peptide;C-reactive protein;Carbohydrates;Caring;Cell Physiology;Cells;Child;Childhood;Clinical;clinical center;clinical research site;cohort;Complement;Complement Factor H;Continuous Glucose Monitor;Copy Number Polymorphism;County;Demographic Factors;deprivation;design;Deterioration;Development;Diabetes Mellitus;diabetic;Diagnosis;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;Discrimination;Disease;Early Diagnosis;Early identification;Edetic Acid;Enzymes;epidemiology study;Erythrocytes;Ethnic Origin;experience;Exposure to;Family;Feces;Functional disorder;Future;Gene Dosage;Genetic;Genomic DNA;Glucose;Glucose tolerance test;glycemic control;Glycosylated hemoglobin A;high risk;Immune Response Genes;Impaired fasting glycaemia;impaired glucose tolerance;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;Innate Immune Response;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention Studies;Intravenous;intravenous glucose tolerance test;Islet Cell;Leukocytes;Life Style;Literature;Mental Health;Metabolic;Metabolic dysfunction;microbiome;Morbidity - disease rate;Multi-site clinical study;Natural Immunity;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;OGTT;Ohio;Oral;Pattern;peripheral blood;Phenotype;Physical activity;Plasma;Play;Poverty;prevent;Process;prospective;Prospective, cohort study;Proteins;Protocols documentation;psychologic;psychosocial;Psychosocial Factor;Race;Recommendation;Recording of previous events;recruit;Research;response;Risk;Risk Factors;Role;Rural;rural setting;Saliva;Sampling;screening;sex;social health determinants;Social Impacts;socioeconomics;Standardization;stool sample;Stress;urban setting;Variant;waist circumference;Weight;Weight Gain;Youth

PROJECT_TITLE: Identify risk factors for type 2 diabetes in adolescents


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Diabetes;Obesity

PHR: Obesity is a major health problem associated with metabolic syndrome and type II diabetes and the control of adiposity is a top priority in managing these diseases. Promoting thermogenesis may not only help in combating obesity but also in improving glucose/insulin homeostasis. This research is to understand how thermogenesis is regulated upon norepinephrine/cold stimulation by increasing PKA activity and may provide new therapeutic targets for obesity/diabetes.

PI_NAMEs: SUL, HEI SOOK  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: A kinase anchoring protein;Ablation;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Adult;Affect;Agonist;Amino Acid Motifs;Binding;Biochemical;Biology;Blood Vessels;Body Temperature;Brown Fat;Calcineurin;Cell membrane;Cells;Chronic Disease;Co-Immunoprecipitations;conditional knockout;Consensus;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;design;Diabetes Mellitus;Disease Management;Docking;Epidemic;FK506;Forskolin;Future;gain of function;Gene Expression;Gene Proteins;Generations;genome-wide;Glucose;Glucose Clamp;Health;Homeostasis;Hyperinsulinism;improved;in vitro activity;in vitro Assay;in vivo;inhibitor;Insulin;Insulin Resistance;insulin sensitivity;interest;knock-down;Knockout Mice;Length;live cell imaging;loss of function;LoxP-flanked allele;Measures;Mediating;Membrane;Metabolic Diseases;Metabolic syndrome;Mitochondria;Mus;mutant;Myristic Acylation Site;myristoylation;N-terminal;Names;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;Obesity;obesity prevention;Organ;overexpression;Oxygen Consumption;Phosphorylation;Phosphotransferases;Physiological;prevent;Process;promoter;Protein Dephosphorylation;protein protein interaction;Proteins;Reporter;Research;Resistance;Role;sensor;Signal Transduction;Signaling Molecule;small hairpin RNA;small molecule therapeutics;Testing;therapeutic target;Thermogenesis;Time;Tissues;Transgenic Mice;Variant

PROJECT_TITLE: MICT1 function in thermogenesis


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Complementary and Integrative Health;Neurosciences;Pain Research;Rehabilitation

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The goal of this U24 application is to establish an inclusive research network to identify mechanisms through which soft tissue manipulations exert biological effects on the nervous system, as well as on non-neural cells and tissues. The Neuronal & Systems Mechanisms of Affective Touch & Therapeutic Tissue Manipulation Research (NeuronS_MATTR) Network will nucleate an emerging field focused on the neurobiology of soft tissue mechanotherapies. Through combinations of multidisciplinary conferences, summer schools, pilot projects and dissemination programs, NeuronS_MATTR will address high-priority areas to elucidate the neural mechanisms of forced-based manipulations.

PI_NAMEs: GERLING, GREGORY JOHN;LUMPKIN, ELLEN A (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Adult;Affect;Affective;American;Animal Model;anxiety reduction;Area;Attenuated;Basic Science;Biological;Body System;career;cell type;Cells;Chronic;Clinical;Collaborations;Computer Models;cytokine;Development;Discipline;Engineering;Epithelial Cells;equity, diversity, and inclusion;Ethnic Origin;Fibroblasts;Fostering;Gender;Geographic Locations;Goals;healing;Health;Human;human subject;Immune;Immune system;Individual;Industry;Inflammation;innovation;innovative technologies;Integumentary system;Interdisciplinary Study;intersectionality;Intervention;Intractable Pain;Knowledge;Mammals;Manipulative Therapies;Manuals;Massage;Measures;Mechanical Stimulation;mechanical stimulus;Mechanics;Mediating;Methodology;Mission;Molecular;Moods;multidisciplinary;Mus;Musculoskeletal System;Nervous System;Nervous System Physiology;neural;Neural Pathways;Neurobiology;neuromechanism;neuromusculoskeletal;Neurons;Neurosciences;opioid epidemic;Pain;Pain management;pain relief;Pathway interactions;Patient Outcomes Assessments;Patients;pharmacologic;Pharmacological Treatment;Physical therapy;Physiological;Physiology;Pilot Projects;Population;program dissemination;programs;psychosocial;Publications;Relaxation;repaired;Research;Research Personnel;Research Priority;Resources;response;Schools;Scientist;Signal Transduction;social;socioeconomics;soft tissue;spatiotemporal;Stress;symposium;System;Techniques;Technology;Therapeutic;Therapeutic Effect;Therapeutic Touch;Tissues;tool;Touch sensation

PROJECT_TITLE: NeuronS_MATTR Network: Neuronal & Systems Mechanisms of Affective Touch & Therapeutic Tissue Manipulation Research Network


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: Project Narrative Tissue structural cells can harbor ‘inflammatory memory’ of prior inflammatory responses in the form of stable epigenetic modifications that alter their transcriptional potential and behavior following subsequent tissue damage but how T cells influence inflammatory memory in the skin is unknown. In this proposal, we will examine the cross-talk between T cell derived cytokines and structural cells in vitro culture systems, in a murine model of T cell-dependent skin inflammation, and in samples from patients with inflammatory skin diseases to mechanistically dissect reprogramming of structural cells by T cells, and determine if this process can be targeted therapeutically to block cutaneous inflammation.

PI_NAMEs: CAMPBELL, DANIEL J (contact);DEBERG, HANNAH ;GRATZ, IRIS KARINA

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Atopic Dermatitis;B-Lymphocytes;Behavior;CD4 Positive T Lymphocytes;cell behavior;Cell Culture System;Cell Physiology;Cells;Chemicals;Cutaneous;cytokine;Development;Disease;Drug Targeting;Endothelial Cells;Epigenetic Process;Fibroblasts;Fibrosis;Functional disorder;Genetic Transcription;Host Defense;Human;humanized mouse;Immune;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Irritants;keratinocyte;Knowledge;Link;Mediator;Memory;microbial;Modality;Modification;Monitor;mouse model;novel;novel therapeutics;Organism;pathogen;Pathway interactions;Patients;pre-clinical;Pre-Clinical Model;prevent;Process;programs;Pruritus;Psoriasis;Resolution;response;Sampling;Signal Transduction;Site;Skin;skin barrier;skin disorder;Stimulus;System;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;tissue repair;Tissue Sample;tissue-repair responses;Tissues;Trauma;Ultraviolet Rays;Vascular Endothelial Cell

PROJECT_TITLE: Reprogramming of tissue structural cells by cutaneous CD4+ T cells


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE STATEMENT A key challenge for psychiatry and clinical psychology is to discover, understand, and ultimately to treat the root causes of the most serious and debilitating mental illness, including schizophrenia and other psychotic disorders. This project will harness an innovative combination of state-of-the-art technologies — including brain imaging and smartphone-based mobile surveys— to objectively identify and prioritize the pathways that promote paranoia, a common, debilitating, and treatment-resistant symptom of psychosis. This project will provide a potentially transformative opportunity to identify new treatment targets and to accelerate the development of digital interventions that are scalable, customizable, and inexpensive.

PI_NAMEs: BLANCHARD, JACK J. (contact);SHACKMAN, ALEXANDER JOSEPH

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Acceleration;Acute;affective neuroscience;Amendment;Amygdaloid structure;Animals;Anterior;Anxiety;anxious;Arousal;Belief;Benign;Biological;biopsychosocial;Brain;brain based;Brain imaging;Cellular Phone;Clinical Psychology;clinically significant;Communities;Complex;Cues;Data;Delusions;Development;Diagnosis;digital intervention;Dimensions;Discipline;Disease;disease classification;Emotional;emotional stimulus;Enrollment;Environment;Etiology;experience;Face;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Human;ideation;Image;Individual;innovation;insight;Insula of Reil;Intervention;Life;man;Measures;Mediating;Mental disorders;Methods;Modeling;multidisciplinary;multimodal neuroimaging;National Institute of Mental Health;negative affect;neural;neuroimaging;neurophysiology;Neurophysiology - biologic function;Neurosciences Research;novel;Paranoia;Pathway interactions;Patients;Pattern;Perception;Perfusion;Play;Prefrontal Cortex;Process;Productivity;Psychiatric Diagnosis;Psychiatry;Psychopathology;Psychoses;Psychotic Disorders;public health relevance;Regulation;Reporting;Research;Research Domain Criteria;Research Personnel;Resistance;response;Rest;Role;Sampling;Scanning;Schizophrenia;social;Stimulus;Structure of terminal stria nuclei of preoptic region;Support System;Surveys;Symptoms;System;Technical Expertise;Techniques;Technology;Testing;theories;Therapeutic;Time;trait;translational model;United States National Institutes of Health;vigilance;Work

PROJECT_TITLE: Using Multimodal Neuroimaging and Real-World Experience Sampling to Understand Negative Affect and Paranoid Ideation in Psychosis

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]