NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Amino Acid Substitution;Amyotrophic Lateral Sclerosis;autosome;Axon;Axonal Transport;Base Pairing;Binding;biological adaptation to stress;Brain;Cell Death;Cell Nucleus;Cells;Chemicals;Complex;Corpus striatum structure;Cytoplasm;Cytoskeleton;Cytoskeleton Alteration;DCTN2 gene;Deposition;dimer;DNA Sequence Alteration;Dopamine;dopamine transporter;dopaminergic neuron;dynactin;Dynein ATPase;early embryonic stage;Endoplasmic Reticulum;Functional disorder;Genes;Glycine;Health;Huntington Disease;Hypoventilation;Impairment;in vitro Assay;in vivo;Inflammation;insight;Intracellular Transport;Investigation;Kinesin;Knock-in;Knockout Mice;Link;link protein;Lower Motor Neuron Disease;Mediating;Mental Depression;Microtubules;Midbrain structure;Missense Mutation;Mitosis;Mitotic spindle;Molecular;Motor;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;Movement;Mus;Mutant Strains Mice;Mutation;Nerve Degeneration;Nerve Endings;Nerve Fibers;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;old mice;overexpression;Parkinson Disease;Pathogenicity;Play;Positioning Attribute;Process;Property;protein complex;Protein Export Pathway;Proteins;Research;retrograde transport;Role;Sensory;Serine;Shapes;Signal Transduction;Spinal;Structure;Swelling;Symptoms;Syndrome;TNFRSF5 gene;Transgenic Mice

PROJECT_TITLE: Pathogenic Mechanisms of Dynactin p150glued in ALS and Parkinson's Disease


ACTIVITY: ZIA

ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: COOKSON, MARK  (contact)

PROJECT_TERMS: Affect;age related neurodegeneration;Alzheimer's Disease;Area;ATAC-seq;Biological;Biological Models;Brain;Brain region;cell type;Cells;Chromatin;Code;Data;Data Set;Disease;Epigenetic Process;Frontotemporal Dementia;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;Goals;Human;interest;LRRK2 gene;Measures;Messenger RNA;Methods;Microglia;MicroRNAs;Mutation;Nerve Degeneration;novel;Parkinson Disease;Pattern;Phenotype;Proteins;Research;Series;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Gene expression in the human brain


PROJECT_TITLE: Leucine rich repeat kinase 2 and dominantly inherited Parkinson disease


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

PI_NAMEs: SINGLETON, ANDREW  (contact)

PROJECT_TERMS: advanced analytics;base;Cloud Computing;Code;cohort;Communities;comorbidity;Complex;computerized data processing;computing resources;Data;data harmonization;Data Set;density;Disease;disease-causing mutation;DNA sequencing;Genes;Genetic;genetic architecture;Genetic Risk;genome sequencing;genome wide association study;genome-wide;Genomic Segment;Genotype;Heritability;Individual;insight;interest;Neurodegenerative Disorders;novel;Parkinson Disease;Population;Population Heterogeneity;pre-clinical;programs;Research;Research Personnel;Resources;Risk Assessment;Risk Factors;risk variant;Science;sex;Time;Tissues;volunteer;whole genome;Work

PROJECT_TITLE: Genome wide SNP analysis in Parkinson's disease


PROJECT_TITLE: DJ-1 and hexokinases


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biotechnology;Brain Disorders;Dementia;Dystonia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Age;alpha synuclein;Alzheimer's Disease;Ataxia;CTSB gene;Data;Disease;Dystonia;experimental study;Family;Frontotemporal Dementia;Gene Expression;Genes;Genetic;genome sequencing;genome wide association study;Individual;induced pluripotent stem cell;insight;Link;LRRK2 gene;Manuscripts;Maps;Modeling;Molecular;Molecular Biology;Motor Neuron Disease;Multiple System Atrophy;Mutation;Nature;Nervous System Disorder;novel;Onset of illness;Outcome;Parkinson Disease;Primary Lateral Sclerosis;Process;Reporting;Risk;risk variant;Role;structural biology;System;tool;Validation;Variant;whole genome;Work

PROJECT_TITLE: Assessment of Candidate Loci in Neurological diseases


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biotechnology;Brain Disorders;Dementia;Dystonia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;arm;Ataxia;autosome;Data;Dementia;Disease;DNA Sequence Alteration;Dystonia;Essential Tremor;exome sequencing;Family;Frontotemporal Dementia;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;genome sequencing;genomic locus;Genotype;Medicine;Movement Disorders;Mutation;Nervous System Disorder;novel;Parents;Parkinson Disease;Patients;Phenotype;Probability;programs;public-private partnership;Recording of previous events;Sampling;Science;tool;volunteer;whole genome;Work

PROJECT_TITLE: Genetic analysis in families with neurological disease


PI_NAMEs: CAI, HUAIBIN  (contact)

PROJECT_TERMS: Ablation;Acceleration;Cell Nucleus;Corpus striatum structure;Darkness;Deceleration;Discrimination;dopaminergic neuron;Dorsal;Genetic;Light;Link;Locomotion;Mediating;Motivation;Motor;motor control;mouse model;Movement;Movement Disorders;Mus;Neurons;Optics;Parkinson Disease;Pathway interactions;Positioning Attribute;response;Speed;striosome;Structure;Testing;walking speed

PROJECT_TITLE: Striosomes Constrain Locomotor Vigor in Parkinson's disease and Other Movement Disorders


NIH_SPENDING_CATS: Aging;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Endocannabinoid System Research;Neurosciences

PI_NAMEs: CHIA, CHEE W (contact)

PROJECT_TERMS: 21 year old;Agonist;animal data;antagonist;Beta Cell;blood glucose regulation;Brain;cannabinoid receptor;Clinical;CNR1 gene;Cross-Over Studies;Dose;Double-Blind Method;Drug usage;Endocannabinoids;endogenous cannabinoid system;Food;Functional Magnetic Resonance Imaging;Glucose;Glucose Clamp;Homeostasis;hormone regulation;Human;Human Biology;Hyperglycemia;Image;improved;Insulin;insulin secretion;insulin sensitivity;Intervention;Islets of Langerhans;Medical;men;Nabilone;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;Outcome;pancreatic juice;Peripheral;Persons;Pharmaceutical Preparations;Placebo Control;Placebos;pre-clinical;Procedures;Randomized;recruit;Regulation;Research Design;response;Role;Tissues;virtual;Visit;visual stimulus

PROJECT_TITLE: CLINICAL PROJECT:  The endogenous cannabinoid system and glucose homeostasis


NIH_SPENDING_CATS: Aging;Clinical Research

PROJECT_TERMS: 1 year old;Adult;Adverse effects;Adverse event;age related decline;aged;Arthralgia;Atrophic;Autoimmunity;Bone Density;Bone Marrow;Carpal Tunnel Syndrome;Cellularity;Clinical;Clinical Research;clinically relevant;Data;Data Analyses;Diabetes Mellitus;Dose;Edema;Elderly;Endocrine system;Fatty acid glycerol esters;Female;Frequencies;Future;Glucose Intolerance;Growth;healthy aging;Hormone use;Human;human subject;Hypophysectomy;Immune;immune function;Immune response;Immune system;Incidence;Individual;Infection;Infiltration;Infusion Pumps;Injections;interest;lean body mass;Life;Link;male;Malignant Neoplasms;metabolic profile;Morbidity - disease rate;mortality;Mus;Muscle;Persons;Physiological;Pituitary Gland;Process;Production;progenitor;r-hGH-M;Rattus;recruit;Rodent;Role;side effect;Somatotropin;subcutaneous;T-Lymphocyte;theories;Thymus Gland;Thymus Hyperplasia

PROJECT_TITLE: CLNICAL PROJECT:  Growth Hormone Administration and the Human Immune System


NIH_SPENDING_CATS: Aging;Hematology

PI_NAMEs: EGAN, JOSEPHINE  (contact)

PROJECT_TERMS: age group;Anemia;Clinical;Development;Diagnostic;Dysmyelopoietic Syndromes;Elderly;Frequencies;Goals;improved;Inflammation;Kidney Failure;late life;Patients;Physical Function;Physical Performance;Population;Quality of life;Research;stem cells;Testosterone;Therapeutic;young adult

PROJECT_TITLE: CLINICAL PROJECT:  Understanding Late Life Anemia


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

PI_NAMEs: BROSH, ROBERT  (contact)

PROJECT_TERMS: 3-Dimensional;Adenine;Antibodies;Apoptosis;Base Pairing;Binding;Biochemical;Biological;cancer therapy;carboxylate;Cell Aging;Cell Cycle Arrest;Cell Death;Cell Line;cell type;Cells;Centromere;chemical bond;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Computational algorithm;Cytosine;Detection;DNA;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA Polymerase I;DNA Sequence;DNA Structure;DNA-Directed DNA Polymerase;Enzyme Interaction;Escherichia coli;experimental study;G-Quartets;Gene Expression;Genes;Genomics;Guanine;helicase;Human;Human Genome;Immunofluorescence Immunologic;In Vitro;in vivo;intercalation;Investigation;Knock-out;Ligands;Metabolic Pathway;Metabolism;Molecular;mutant;novel;pharmacologic;Phenotype;preservation;prevent;promoter;Promoter Regions;Proteins;Reagent;Recombinants;Regulation;Reporting;Research;Resolution;response;senescence;single walled carbon nanotube;skills;small molecule;Structure;Techniques;Telomerase;telomere;TERF1 gene;Testing;Thymine;Work

PROJECT_TITLE: Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: EVANS, MICHELE K (contact)

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;adverse childhood events;Affect;African American;African American population;Age;age acceleration;age effect;age-related disease;Aging;aging clocks;Animal Model;anti aging;Baltimore;base;Biological;biological age;Biological Aging;Biological Markers;Biology;bisulfite;Blinded;Blood;Caucasians;cell type;Chronology;Clinical;Cognitive;cohort;Cohort Studies;CpG dinucleotide;Cytosine;Data;Demographic Factors;deprivation;Development;DNA;DNA Methylation;Education;Environmental Exposure;environmental stressor;epidemiology study;Epigenetic age;epigenetic aging;Epigenetic Process;epigenome;epigenomics;European ancestry;Female;fitness;Gene Expression Regulation;Genetic;Genetic Variation;genome-wide;Genomics;Health;health care availability;health disparity;health outcome disparity;healthspan;healthy aging;Household;Human;human model;human old age (65+);Income;Individual;late life;Lead;Life Experience;life span;lifestyle factors;Linear Regressions;Liver;Longitudinal cohort study;male;Measures;men;Methods;Methylation;methylation biomarker;middle age;Minority Groups;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Obesity;Outcome;Participant;Peripheral Blood Mononuclear Cell;Phenotype;poor health outcome;Population;Positioning Attribute;Poverty;premature;Process;Psychosocial Stress;Publications;Race;racial diversity;randomized, clinical trials;rate of aging;Regression Analysis;Residual state;Role;Sampling;senolytics;sex;Site;social;Social Class;social health determinants;Socioeconomic Status;socioeconomics;Specific qualifier value;stressor;Structural Racism;Students;Time;Tissues;Visit;Whole Blood;Woman;Work

PROJECT_TITLE: Effects of race and socioeconomic status on the epigenetic aging clock


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Adult;African American;African American population;Age;age acceleration;age group;age related chronic disease;age-related disease;Alzheimer's Disease;Biological;biological age;Biological Assay;Biological Markers;Cancer Patient;Cardiovascular Diseases;CCL2 gene;Cells;Cessation of life;chemokine;Chronic;Chronic Disease;chronic inflammatory disease;Circulation;Communication;COVID-19 pandemic;cytokine;Data;Death Rate;design;Diagnosis;Diagnostic;diagnostic development;Disease;Disparity;E-Selectin;Epidemiology;Ethnic Population;Etiology;exosome;extracellular vesicles;Fibrinogen;frailty;Gene Expression;genetic information;Health;health disparity;healthy aging;Human;Immune response;in utero;Individual;Inflammation;Inflammatory;inflammatory marker;intercellular communication;Interferon Type II;Interleukin-6;Interleukins;Laboratories;Life Expectancy;life span;Link;link protein;Longevity;Longitudinal Studies;low socioeconomic status;Malignant Neoplasms;Medical;men;Messenger RNA;Metabolic Diseases;Methods;MicroRNAs;microvesicles;middle age;Minority;Molecular;mortality;mortality risk;Mothers;Mutation;Neighborhoods;Neurodegenerative Disorders;normal aging;Nucleic Acids;Outcome;P-Selectin;Paper;Participant;Pathologic;Pathway interactions;Phenotype;Physiological;Play;Population;population based;Population Sciences;Populations at Risk;Poverty;Preparation;Probability;Proteins;Race;racial population;receptor;receptor for advanced glycation endproducts;Research;Risk;Risk Factors;RNA;Role;senescence;senescence associated secretory phenotype;senescent cell;Serum;Serum Proteins;sex;Technology;Therapeutic;TNF gene;Translating;trend;United States;Untranslated RNA;Vesicle;Woman;Work

PROJECT_TITLE: Characterization of Serum Extracellular Vesicles with Human Age


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BEERMAN, ISABEL  (contact)

PROJECT_TERMS: Adult;Age;age related;age related changes;Aging;Animals;Attenuated;Autoimmunity;Automobile Driving;Biological;Biological Models;Blood;Breeding;candidate identification;Categories;Cell Aging;Cell Compartmentation;Cells;Disease;DNA Damage;DNA Methylation;DNA Repair;Dysmyelopoietic Syndromes;Epigenetic Process;epigenetic regulation;experimental study;falls;Genes;Hematopoietic;hematopoietic stem cell aging;Hematopoietic stem cells;Homeostasis;Human;interest;Intervention;leukemia;Lymphoid;Maintenance;mouse model;Mus;nonhuman primate;Norway;Pathway interactions;Phenotype;prevent;primitive cell;Rattus norvegicus;Recording of previous events;regeneration potential;Research;response;restoration;sex;Solid;stem cell aging;stem cells;System;targeted treatment;Therapeutic Intervention;therapeutic target;Work

PROJECT_TITLE: Characterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic intervention


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: GREIG, NIGEL H. (contact)

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Acute;Adult;Adverse effects;Affect;Age;age-related disease;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;analog;Animal Model;Animals;Anti-Inflammatory Agents;antiangiogenesis therapy;Antineoplastic Agents;Antioxidants;Appearance;Atrophic;Automobile Driving;Back;Behavioral;Binding;Blood Vessels;Brain;Cell Death;Cell model;Cell Transplantation;Cells;cerebral atrophy;Cerebrovascular system;Chemistry;Chick Embryo;Chronic;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;Cognitive deficits;combat;Complex;course development;cytokine;cytokine release syndrome;Degenerative Disorder;Dementia;Deposition;Detection;Development;Disease;Disease Progression;DNA Damage;Dose;Drug Kinetics;Drug Targeting;drug-like compound;effective therapy;efficacy evaluation;Elderly;Elements;Embryo;entorhinal cortex;Evaluation;Event;Excision;Failure;Generations;Genes;glial activation;Growth;hallmarks of aging;healing;Human;Impaired cognition;Impairment;in utero;in vivo;Inflammation;Inflammatory;Innate Immune System;Interruption;Intervention;Ischemic Stroke;Knowledge;Legal patent;Libraries;Lipid Peroxidation;Lymphocytic Infiltrate;Maintenance;Mannans;MAPT gene;Mediating;Messenger RNA;Microglia;Mitochondria;Modeling;Modification;mouse model;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurologic;Neurology;neuron loss;Neurons;neuropathology;neuropsychiatric disorder;neurotoxic;normal aging;novel;Oxidative Stress;Parkinson Disease;Pathologic;Pathology;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Physiological;Plasma;pomalidomide;Positron-Emission Tomography;posttranscriptional;pre-clinical;preclinical study;Production;protein aggregation;protein oligomer;Proteins;proteostasis loss;Psychiatry;Reactive Oxygen Species;Reporting;resilience;response;Rodent;Rodent Model;Role;screening;Sedation procedure;Source;Structure;Symptoms;Synthesis Chemistry;tau aggregation;tau Proteins;tau-1;Teratogens;Thalidomide;Time;TNF gene;Toxic effect;Toxicology;Traumatic Brain Injury;treatment strategy;Vertebral column;Zebrafish

PROJECT_TITLE: Pro-inflammatory cytokine lowering anti-inflammatory drugs


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes

PROJECT_TERMS: 21 year old;Adult;Anabolism;animal data;Animals;Blood specimen;Cell Line;Chronic Obstructive Pulmonary Disease;Cilostazol;Clinical;Clinical Data;Cross-Over Studies;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Data Analyses;Double-Blind Method;Family;fasting glucose;FDA approved;glucagon-like peptide 1;Glucose;glucose sensor;Glucose Transporter;glycemic control;Hour;Human;Human Biology;Hydrolysis;improved;inhibitor;inorganic phosphate;Intermittent Claudication;Investigation;L Cells;Medical;Multicenter Studies;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Outcome;Pathway interactions;Pentoxifylline;Periodicity;Persons;Pharmaceutical Preparations;Phosphodiesterase Inhibitors;phosphoric diester hydrolase;Phosphoric Monoester Hydrolases;Placebo Control;Placebos;pre-clinical;Process;proglucagon;Randomized;recruit;Regulation;Role;Rolipram;Route;Sodium;sweet taste perception;symporter;Taste Buds;Testing;Visit

PROJECT_TITLE: CLINICAL PROJECT:  The Role of Phosphodiesterase Inhibitors in Incretin Secretion


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: LAUNER, LENORE J (contact)

PROJECT_TERMS: African American;Age;Age Years;aging brain;Alabama;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;bioimaging;Blood Vessels;Body Composition;Brain;Brain Diseases;brain health;brain magnetic resonance imaging;Brain region;brain tissue;Cardiovascular Diseases;cardiovascular risk factor;Chicago;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive function;cohort;Cohort Studies;Collaborations;Data;Dementia;Disease;Early identification;Education;endophenotype;Environment;Environmental Exposure;epidemiology study;Ethnic Origin;Evolution;follow-up;Follow-Up Studies;Future;gene environment interaction;Genes;Genetic;genetic architecture;Genetic Markers;Genetic Risk;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide analysis;Geographic Locations;Goals;Heart;Hospital Records;human old age (65+);Immune response;International;Investigation;Island;Italy;Joints;Life Cycle Stages;lipid metabolism;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;men;Mental Depression;Metabolic;Methylation;mild cognitive impairment;Musculoskeletal;Neurocognitive;non-genetic;Nonprofit Organizations;novel;offspring;Outcome;Participant;Pathogenesis;Pathway interactions;Persons;Phenotype;Physiological;Population;population based;Prevention;prospective;Proteomics;Protocols documentation;recruit;Regulation;Research Personnel;Research Project Grants;Risk Factors;Sampling;Sardinia;screening;sex;Stroke;Structure;study population;System;trait;Universities;whole genome;Woman;young adult

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Genetic Markers of Brain Aging


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteoporosis;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: Accelerometer;adjudication;African American;African American Women;aged;Aging;Ancillary Study;Behavioral;Biological Markers;Biopsy;Black race;Body Composition;bone;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Clinic;clinical examination;cognitive function;cohort;Communities;Data;Data Analyses;Dementia;design;Diabetes Mellitus;Disease;Disease susceptibility;Dual-Energy X-Ray Absorptiometry;Eligibility Determination;Environment;Event;Extramural Activities;Fatty acid glycerol esters;follow-up;Fracture;functional decline;functional disability;Funding;gender difference;genetic risk factor;genomic locus;Grant;Health;Hip region structure;Home visitation;Hospitalization;indexing;Interview;Knee Osteoarthritis;Longitudinal cohort;loss of function;Lung Diseases;Malignant Neoplasms;Measurement;Measures;member;men;Mental Depression;Metabolic Diseases;Monitor;Motor Skills;Muscle;muscle strength;older adult;Older Population;Osteoporosis;Outcome;Outcome Study;Parents;Participant;Pathway interactions;Pennsylvania;Physical Function;Protocols documentation;racial difference;Reporting;Research;Research Personnel;secondary analysis;Site;standard measure;Surveys;Telephone;Tennessee;Walking;Weight;Woman;Wrist;X-Ray Computed Tomography

PROJECT_TITLE: Health, Aging and Body Composition Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Hypertension;Microbiome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Arteries;Asia;Auditory;Autopsy;Base Sequence;bioimaging;Biological Markers;biological systems;Blood;Blood Pressure;blood pressure elevation;Blood Vessels;Brain;brain magnetic resonance imaging;brain volume;Cardiovascular Diseases;cardiovascular risk factor;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Characteristics;Clinical;Clinical Data;Clinical Distribution;Cognition Disorders;Cognitive;cognitive function;cohort;Cohort Studies;comorbidity;Coronary;Coronary Artery Risk Development in Young Adults Study;Data;Dementia;design;Diabetes Mellitus;Disease;Environment;Epidemic;epidemiology study;Etiology;follow-up;Funding;Genes;Genetic;Glial Fibrillary Acidic Protein;gut microbiome;Heart Diseases;hemodynamics;human old age (65+);Hypertension;imaging biomarker;Intervention;Investigation;Japanese American;Lead;Lesion;Life Experience;Light;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurable;Measures;men;Metabolic;microbiome;Microvascular Dysfunction;middle age;mild cognitive impairment;molecular marker;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neuroepidemiology;neurofilament;neuropathology;non-genetic;novel;Observational epidemiology;Outcome;Pathogenesis;Pathology;Pathway interactions;Pattern;Perfusion;Persons;Plasma;Population;Positron-Emission Tomography;Predisposition;Prevention;programs;Prospective Studies;public health priorities;Publications;Reporting;Research;Research Design;Research Project Grants;Resources;Retina;Risk;Risk Factors;Risk Reduction;Role;sedentary lifestyle;Shapes;Smoking Behavior;Spatial Distribution;Structure;System;tau Proteins;Testing;Therapeutic;Tissues;trait;Water;white matter;Woman;Work

PROJECT_TITLE: ALZHEIMER RESEARCH PROJECT: Brain aging and cardiovascular risk factors and disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: HAFNER, MARKUS  (contact)

PROJECT_TERMS: assay development;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological Sciences;Breathing;Carrier Proteins;Catalogs;cell type;Cells;combinatorial;crosslink;Data;deep sequencing;Development;Disease;drug development;Elements;Experimental Models;exportin 5;Exportins;Fluorescent in Situ Hybridization;Formalin;Gel;Gene Expression;Gene Expression Regulation;Gene Family;Genes;Genetic Variation;Genome;genome-wide;Goals;Human;Human Genetics;Immunoprecipitation;improved;In Situ Hybridization;Individual;insight;Karyopherins;Libraries;Maps;Mass Spectrum Analysis;member;Messenger RNA;Methods;MicroRNAs;Molecular;Molecular Medicine;Mutation;novel anticancer drug;Nuclear Export;nucleocytoplasmic transport;Nucleocytoplasmic Transport Proteins;Paraffin Embedding;particle;Pathologic Processes;Phenotype;Polyadenylation;Post-Transcriptional Regulation;Process;Property;Protein Export Pathway;Proteins;Proteomics;Regulation;Reporter;Ribonucleic Acid Regulatory Sequences;Ribonucleoproteins;Ribonucleosides;RNA;RNA Binding;RNA Processing;RNA Splicing;RNA Transport;RNA-Binding Proteins;Role;Running;Silver Staining;Site;Specificity;stem;System;Technology;Therapeutic Intervention;Time;Tissue Embedding;Transcript;Translations;Transport Process;Untranslated RNA;Variant;virtual;Visualization

PROJECT_TITLE: Dissecting the role of shuttling mRNA binding proteins in nucleocytoplasmic RNA transport


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PROJECT_TERMS: Adult;Animals;B-Lymphocytes;Binding;Binding Sites;Biological Models;Caenorhabditis elegans;Cell Line;Cells;cis acting element;Code;cofactor;Collaborations;CRISPR/Cas technology;Data;derepression;Development;Disease;embryo tissue;Event;Exhibits;experimental study;Family;Family member;fetal;Future;gain of function;Gene Expression Regulation;Genes;genome editing;genome-wide;Goals;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Human;Immunology;insight;Investigation;Maps;member;Messenger RNA;MicroRNAs;Modeling;Molecular;Mus;mutant;National Institute of Allergy and Infectious Disease;Outcome;overexpression;Pattern;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Protein Family;Proteins;Proteomics;Regulation;Repression;Resolution;Ribonucleoproteins;RNA;RNA-Binding Proteins;Role;Shock;Site;Specific qualifier value;stem cells;synergism;System;Technology;Tissues;Transcript;Untranslated RNA

PROJECT_TITLE: Integration of the results from systems-level determination of cis-acting elements into high-resolution maps of posttranscriptional regulatory events.


NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TERMS: Affect;Binding;Binding Sites;Biochemical;Biological Assay;Cell Nucleus;Cells;Cellular Stress;Coupled;Cytoplasm;Disease;DNA;Elements;Embryonic Development;Eukaryota;Event;G-Quartets;gain of function;Gene Expression;Genetic Transcription;Genome;genome-wide;helicase;Human Cell Line;In Vitro;Initiator Codon;Knock-out;loss of function;Malignant Breast Neoplasm;Mammalian Cell;Mammals;Maps;Measures;Messenger RNA;Methods;Molecular;Molecular Chaperones;mRNA Precursor;Muscular Dystrophies;nucleic acid binding protein;Nucleic Acids;Nucleotides;Output;Phosphorylation;prevent;Process;programs;Protein Isoforms;protein kinase R;Proteins;Protocols documentation;Regulon;Research;Resolution;ribosome profiling;Ribosomes;RNA;RNA Polymerase II;RNA Stability;RNA-Binding Proteins;stress granule;Structure;System;Tissues;transcription factor;Translating;Translation Initiation;Translational Regulation;Translations;Untranslated Regions;Zinc Fingers

PROJECT_TITLE: Impact of RNA binding proteins on translation initiation and elongation.


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PI_NAMEs: BAXEVANIS, ANDREAS  (contact)

PROJECT_TERMS: Adult;Ally;Animals;Appearance;Arthropods;Atlases;Binding;Biological;Biological Models;Biology;cell type;Cells;Chromatin;Chromosomes;Cnidaria;Code;comparative;comparative genomics;Complex;Ctenophora;Data;Data Set;data sharing;database structure;Databases;Development;Developmental Biology;Developmental Gene;Disease Outbreaks;DNA Sequence;Elements;Embryonic Development;Enhancers;Epigenetic Process;Evolution;Exhibits;experimental study;Future;Genbank;Gene Expression;Generations;Genes;Genetic Transcription;Genome;genome annotation;genome sequencing;genome-wide;genomic data;Genomics;Glutamate Receptor;Health;Hi-C;homeodomain;Homologous Gene;Human;Human Biology;human disease;Human Genome;innovation;insight;Invertebrates;Knowledge;Laboratories;Light;male;marine;Methods;Methylation;Mnemiopsis;model organism;Modeling;Molecular;Mollusca;Morphology;Muscle Cells;Natural regeneration;neurodevelopment;neurogenesis;Neurons;novel;Organism;Orthologous Gene;Pattern Formation;Phylogenetic Analysis;Play;Positioning Attribute;Process;Property;Protein Family;protein structure;protein structure prediction;Proteins;Proteome;Proteomics;Regenerative capacity;Regenerative Medicine;Regulatory Element;Research;Resources;RNA Sequences;Role;single cell analysis;Sister;Source;Spatial Distribution;Specific qualifier value;stem cell biology;stem cells;Sting Injury;Structure;Supercomputing;Transcript;transcription factor;Transcriptional Regulation;transcriptomics;translational study;Trees;United States National Institutes of Health;Untranslated RNA;vertebrate genome;Vertebrates;Visualization;whole genome;Work

PROJECT_TITLE: Comparative Genomic Studies on the Evolution of Morphological Complexity


ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PI_NAMEs: PHILLIPPY, ADAM  (contact)

PROJECT_TERMS: Agriculture;Area;arm;Bioinformatics;Blue Whales;Cattle;Centromere;Characteristics;Chromosome Structures;Chromosomes;Collaborations;Collection;comparative;Comparative Genomic Analysis;comparative genomics;Complex;Computing Methodologies;cost;Data;Databases;Development;disease diagnosis;Effectiveness;Exclusion;Fertility;functional genomics;Future;Genes;Genetic study;Genome;genomic data;Genomics;Goals;Haplotypes;Human;Human Genome;Human Genome Project;human reference genome;improved;Informatics;Length;Life;Lifting;Macaca;Maize;Maps;member;metagenome;method development;Methods;methylation pattern;microbial genome;migration;Mus;nanopore;Neurologic;nonhuman primate;novel sequencing technology;pan-genome;Paper;Peer Review;Planet Earth;Play;Pongidae;Population;Printing;Process;Publishing;reference genome;Role;Ruminants;Sampling;scalable algorithms;Sexual Development;Shapes;Shark;single molecule;software development;Surveys;Tandem Repeat Sequences;Techniques;Technology;telomere;Time;Update;Validation;Variant;vertebrate genome;Vertebrate Taxonomy;Visualization;whole genome;Work;Y Chromosome;Zebrafish

PROJECT_TITLE: Single-molecule sequence assembly and analysis


ACTIVITY: ZIC

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: GOROSPE, MYRIAM  (contact)

PROJECT_TERMS: Age-associated memory impairment;age-related disease;Aging;aging related;Alzheimer's Disease;Artificial Intelligence;Bioinformatics;Complex;Computational Biology;Data;Data Analyses;database of Genotypes and Phenotypes;Databases;Deposition;Disease;disease phenotype;Environmental Risk Factor;Functional disorder;Genetic;genetic analysis;genetic association;Goals;High-Throughput Nucleotide Sequencing;human disease;Machine Learning;microbiome;microbiome analysis;Process;public database;RNA;Role;Synapses;System;Untranslated RNA;web page;web-based tool

PROJECT_TITLE: Bioinformatic Analysis of the Genetics of Common Complex Diseases


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DE, SUPRIYO  (contact)

PROJECT_TERMS: Aging;Algorithmic Analysis;Artificial Intelligence;biomedical data science;Cells;Cloud Computing;Collaborations;Communities;complex biological systems;Computational Biology;Computer Systems;CRISPR screen;Data Analyses;Data Scientist;data sharing;design;epigenomics;Experimental Designs;Extramural Activities;Fostering;functional genomics;Gene Chips;Genomics;Goals;high end computer;Image Analysis;instrument;Interdisciplinary Study;interest;Laboratories;Mission;Multiomic Data;nanopore;next generation sequencing;novel;Preparation;programs;Quality Control;Research;Research Personnel;Sampling;Scientist;Services;single cell genomics;single cell sequencing;Technology;Training;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Analysis of complex biological systems by high-throughput genomic technologies


NIH_SPENDING_CATS: Aging;Bioengineering;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: WENG, NAN-PING PETER (contact)

PROJECT_TERMS: Animals;Antigens;Apoptosis;Apoptotic;Baltimore;Biological Assay;Blood Cells;Bone Marrow;Bone Marrow Stem Cell;Bromodeoxyuridine;Cell Cycle;Cell Separation;Cells;Certification;Chromosomes;Color;Complex;complex data;Computers and Advanced Instrumentation;Consult;Continuing Education;cost effective;Data Analyses;daughter cell;Dedications;design;Detection;detector;Effectiveness;Epigenetic Process;Event;exosome;Experimental Designs;experimental study;Extramural Activities;Financial Support;Flow Cytometry;Flow Cytometry Shared Resource;Frequencies;Future;Head;high dimensionality;Hour;Human;Immune;Immunofluorescence Immunologic;Immunologics;Individual;innovation;Institution;instrument;instrumentation;Laboratories;Lasers;Lentivirus;Life Cycle Stages;life span;Longitudinal Studies;Manufacturer;Measurement;member;Methylation;Mission;Modification;monocyte;Mus;muscle progenitor cell;nerve stem cell;Neurons;nonhuman primate;novel;operation;particle;Peripheral Blood Lymphocyte;Physiologic pulse;Policies;Population;Procedures;Process;Productivity;programs;Proliferating;Propidium Diiodide;Proteins;Protocols documentation;Publications;Qualifying;Quality Control;Radial;Rattus;recruit;Reporter;Reporter Genes;Research;research and development;Research Personnel;Research Support;Resource Sharing;Resources;RNA;Sampling;Science;Scientist;Services;Side;skills;Sorting;Speed;Spleen;Stains;stem cell population;submicron;Technical Expertise;Technology;technology development;thymocyte;Training;United States National Institutes of Health;Visit;web page

PROJECT_TITLE: Flow Cytometry Laboratory (Scientific Core)


ACTIVITY: ZID

NIH_SPENDING_CATS: Aging

PROJECT_TERMS: aging process;American;Blood Banks;Blood Component Removal;Cells;Cellular Structures;Chronic;Clinical;Collection;Complete Blood Count;Cytapheresis;expectation;Genetic study;Hepatitis;HIV;Hour;Human;immune function;Individual;Infection;Laboratories;Laboratory Study;Leukocytes;liver function;Lymphocyte;Magnetic Resonance Imaging;Medical;Molecular;monocyte;National Institute on Aging;Participant;Procedures;Protocols documentation;Qualifying;Renal function;Research;Research Personnel;Sampling;screening;Testing;trend;Urinalysis;volunteer

PROJECT_TITLE: CLINICAL PROJECT:  Cytapheresis Of Volunteer Donors (MRI 2003-054)


NIH_SPENDING_CATS: Aging;Clinical Research

PROJECT_TERMS: Abdomen;Address;Age;Biomedical Research;Bladder;Blood;Calibration;Caring;Clinical;clinical care;Clinical Research;Clip;Code;Connective Tissue;data acquisition;design;Discipline of Nursing;Disease;Ethnic Origin;Evaluation;Exclusion;Fatty acid glycerol esters;Feces;Gender;Hair;Health Personnel;healthy volunteer;Heart;Hemorrhage;human tissue;Individual;Information Technology;Informed Consent;Infrastructure;interest;Kidney;Laboratories;laboratory equipment;Link;Liquid substance;Liver;Location;Lung;Medical;method development;Muscle;Nail plate;Names;Nose;operation;Operative Surgical Procedures;Organ;Outcome;Participant;participant safety;Pharmacy facility;Physicians;Protocols documentation;Race;Research;Research Personnel;Research Project Grants;Research Subjects;Saliva;Sampling;Secure;Services;Skin;Tissue Sample;Tissues;Urine;Vertebral column

PROJECT_TITLE: CLINICAL PROJECT:  Subject Assessment, Sample Procurement and Clinical Operations


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: MENLO PARK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: BUNIN, DEBORAH  (contact)

PROJECT_TERMS: ADME Study;Animals;Biological;Biological Assay;Biological Testing;candidate identification;chemical synthesis;Clinical;clinical lot;Clinical Research;Clinical Trials;Clinical Trials Network;Contraceptive Agents;Contraceptive Devices;Contraceptive methods;contraceptive target;Contractor;Contracts;Databases;design;Development;Device or Instrument Development;drug candidate;drug development;Drug Formulations;Endocrine;Enrollment;Evaluation;Female Contraceptive Agents;Formulation;Gel;good laboratory practice;Good Manufacturing Process;Implant;In Vitro;in vivo;Injectable;Investigational New Drug Application;Levonorgestrel;lot production;Male Contraceptive Agents;manufacture;manufacturing test;Manuscripts;men;Methods;Microsomes;Mission;National Institute of Child Health and Human Development;Nestorone;new chemical entity;novel;novel therapeutics;Oral;Oral Administration;Ovulation;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Plasma;Play;population health;pre-clinical;preclinical study;Preparation;Process;Prodrugs;product development;Production;Program Development;programs;Protocols documentation;recruit;Report (document);Research;research and development;research clinical testing;Research Personnel;Research Support;Role;Services;sperm cell;sperm function;stability testing;System;Testing;Testosterone;Time;Toxic effect;Translational Research;Woman;Work

PROJECT_TITLE: BIOLOGICAL TESTING FACILITY - DISCOVERY, CLINICAL FORMULATION, AND MANUFACTURE OF CONTRACEPTIVES


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We seek to validate, calibrate, and translate restricted spectrum imaging (RSI-MRI) across vendors to asses in the detection of clinically significant prostate cancer. RSI-MRI is a novel sequence protocol with software post- processing accomplished along with standard of care MRI to improve the quality of prostate MRI imaging. The research has the potential to revolutionize prostate cancer diagnosis and monitoring by providing a non-invasive imaging biomarker with the ability to improve diagnostic accuracy and risk stratification across MRI scanners.

PI_NAMEs: LISS, MICHAEL ANDRE (contact);WHITE, NATHAN SCOTT

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Academic support;Affect;Amendment;Anatomy;Area;Area Under Curve;arm;Biological Markers;biomarker performance;Biopsy;Biopsy Specimen;Calibration;California;cancer biomarkers;cancer cell;cancer diagnosis;Characteristics;Clinical;Clinical Assessment Tool;clinical diagnosis;clinical practice;clinical risk;Clinical Trials;clinically significant;Code;Color;Computer software;Data;Decision Making;Detection;Diagnosis;diagnostic accuracy;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Digital Imaging and Communications in Medicine;Disease;Early Diagnosis;Enrollment;Equipment;FDA approved;Health;High-Risk Cancer;Housing;Image;Image Analysis;imaging biomarker;imaging modality;Imaging technology;improved;in vivo;indexing;Indolent;industry partner;Inflammation;Information Systems;innovation;Institution;interest;Intravenous;intravenous injection;Investigation;Lesion;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Manufacturer;Maps;Measurement;Measures;Medicine;men;Methods;Modality;Modeling;Molds;molecular marker;Monitor;non-invasive imaging;novel;Output;Patients;Pharmaceutical Preparations;Predictive Value;Process;prospective;Prostate;prostate biopsy;prostate cancer cell;prostate cancer risk;Prostatectomy;Protocols documentation;Publishing;radiologist;Radiology Specialty;randomized, clinical trials;Reader;Receiver Operating Characteristics;Reporting;Research;Restriction Spectrum Imaging;risk stratification;Sampling;Sampling Errors;Scanning;Screening for Prostate Cancer;Serum;side effect;Signal Transduction;Source;Specificity;standard of care;Standardization;Statistical Data Interpretation;Structure;System;T2 weighted imaging;Techniques;Time;Tissues;Translating;Translations;tumor;Tumor Markers;ultrasound;United States;Urine;Validation;Variant;Vendor;Water;Work

PROJECT_TITLE: Validation, Calibration, and Translation of Restriction Spectrum Imaging Signal Maps to enhance MRI diagnostic capabilities in Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Vaccine Related;Valley Fever

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: NAGGIE, SUSANNA  (contact)

PROJECT_TERMS: Adult;anti-fungal agents;Antimicrobial Resistance;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;combat;Communicable Diseases;community acquired pneumonia;Conduct Clinical Trials;Contracts;design;Evaluation;Individual;Phase IV Clinical Trials;Pneumonia;Population;programs;Resources;Special Population;Vaccines

PROJECT_TITLE: Vaccine and Treatment Evaluation Units: Phase IV Clinical Trial in Adults with Community Acquired Pneumonia to Assess the Effect of Early Empiric Antifungal Treatment of Coccidioidomycosis Pneumonia


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Transplantation

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PI_NAMEs: GELMAN, BENJAMIN  (contact)

PROJECT_TERMS: antiretroviral therapy;Autopsy;Biological;Central Nervous System;Clinical Data;clinical research site;Cognitive;Consent;data sharing;Ethics;Functional disorder;Funding;HIV;HIV Seronegativity;human subject protection;interest;Mental Health;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National NeuroAids Tissue Consortium;Neurocognitive;Neurologic;Neuropathogenesis;Organ Donor;Outcome;preservation;Process;Qualifying;Research Personnel;Services;Specimen;Tissues;volunteer

PROJECT_TITLE: THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

PI_NAMEs: MOORE, DAVID J (contact)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Transplantation

PROJECT_TERMS: Alzheimer's Disease;Autopsy;Biological;Clinical Data;HIV;HIV Seronegativity;National NeuroAids Tissue Consortium;Organ Donor;Specimen;Tissues;volunteer


ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: MORGELLO, SUSAN  (contact)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: SPERO THERAPEUTICS, INC.

ORG_STATE: MA

PI_NAMEs: KANE, BRIAN  (contact)

PROJECT_TERMS: Acinetobacter;Advanced Development;antimicrobial resistant infection;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;Pseudomonas aeruginosa;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Biodefense, AntiMicrobial Resistant (AMR) Infections and Emerging Infectious Diseases


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: EDELMAN, ALISON  (contact)

PROJECT_TERMS: Adherence;Age;Biological Assay;Body mass index;Clinical;Clinical Trials;Clinical Trials Network;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Drug Kinetics;Enrollment;Estrogens;Evaluation;Female Contraceptive Agents;Formulation;Free Will;Hormones;Implant;Injectable;Injections;Intramuscular;Intrauterine Devices;Laboratories;Lactation;Levonorgestrel;Measures;Mission;National Institute of Child Health and Human Development;Obesity;Pharmaceutical Preparations;Pharmacodynamics;pill;Population;Progestins;Protocols documentation;Public Health;Recording of previous events;recruit;Regimen;reproductive;Risk;Risk Reduction;Route;Safety;subcutaneous;Time;United States Food and Drug Administration;venous thromboembolism;Woman

PROJECT_TITLE: CENTRAL LABORATORY FOR PHARMACOKINETIC/PHARMACODYNAMIC EVALUATION OF LEVONORGESTREL BUTANOATE FOR FEMALE CONTRACEPTION


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rare Diseases;Stomach Cancer

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Gastric cancer is a leading cause of mortality in Latinos. This proposal will characterize the epigenome of common and aggressive genomically stable (GS) gastric tumors in Latinos, model their tumorigenesis using ethnic-appropriate Latino gastric organoids, and identify GS tumor vulnerabilities using a loss of function screen. Our study will generate a body of data that will be useful in understanding GS tumor biology and in addressing cancer disparities in this population.

PI_NAMEs: CARVAJAL CARMONA, LUIS GUILLERMO (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Asian;Asian population;Biological;Biological Assay;Biological Markers;Biology;bisulfite sequencing;California;Cancer Biology;Cancer cell line;cancer health disparity;Cancer health equity;Cancer Patient;CDH1 gene;Cell Adhesion;Cells;Chemoresistance;Classification;Clinic;Country;CpG Islands;Data;Death Rate;Development;Diffuse;Diffuse gastric cancer;Disparity;drug efficacy;druggable target;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Frequencies;functional genomics;gastric organoids;Genes;Genome engineering;Genome Stability;Genomic approach;health disparity;high throughput screening;Histologic;Histology;Immunologics;In Vitro;in vivo;Infrastructure;Intestinal Neoplasms;Intestines;Invaded;Latino;Latino Population;loss of function;malignant stomach neoplasm;Methods;Methylation;minority patient;Modeling;Molecular;molecular subtypes;mortality;mutant;Mutation;Neoplasm Metastasis;neoplasm registry;Organoids;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Phenotype;PI3K/AKT;Population;preclinical study;Prevalence;Primary Neoplasm;Prognosis;Proliferating;Registries;Research;RHOA gene;Sampling;Signal Transduction;social health determinants;stable cell line;stemness;Stomach Neoplasms;synthetic lethal interaction;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic development;transcriptome;Transforming Growth Factor beta;tumor;Tumor Biology;tumor growth;tumorigenesis;Universities;Work

PROJECT_TITLE: Understanding the biology of disparity-associated genomically stable gastric tumors

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Kidney Disease;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: Project Narrative The objective of this Katz R01 project is to develop a novel multi-scale computational model to: 1) quantify the local and systemic hemodynamics (i.e., pressure, flow rate, shear stress, oxygen transport, etc.) during phases of active hemorrhage, aortic occlusion with REBOA, and resuscitation, 2) identify vascular regions that are vulnerable to ischemic damage as a result of the altered hemodynamics, 3) predict key physiologic responses related to vascular compliance, oxygen delivery and renal autoregulation during hemorrhage and aortic occlusion, and 4) determine optimal aortic occlusion size and duration of partial vs. full REBOA strategies to prevent ischemia-reperfusion injuries and renal failure. At its core, this proposal builds on the PI’s training in cardiovascular fluid mechanics, trauma and shock, but represents an important new direction that has the potential to transform the field of hemorrhagic shock research.

PI_NAMEs: RAHBAR, ELAHEH  (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Address;Adopted;Animal Experimentation;Animal Model;Animals;Aorta;Balloon Occlusion;Baroreflex;Behavior;Biological;Biological Markers;Blood flow;Blood Vessels;Blood Volume;Cardiac Output;Cardiovascular system;Catheters;Cessation of life;Chest;Clinical;computer framework;Computer Models;Computer software;computerized tools;Coupled;design;Development;Devices;Distal;Engineering;Environment;Evaluation;Family suidae;Feedback;Growth;hemodynamics;Hemorrhage;Hemorrhagic Shock;Homeostasis;improved;in silico;in vivo;indexing;Injury;innovation;Institution;Intervention;Ischemia;Kidney;Kidney Failure;Knowledge;Liquid substance;Mechanics;Methods;Military Personnel;minimally invasive;Modeling;multi-scale modeling;multidisciplinary;next generation;novel;open source;Oxygen;oxygen transport;Performance;Perfusion;Phase;Physicians;Physiological;porcine model;Pre-Clinical Model;Preclinical Testing;pressure;prevent;preventable death;Renal function;Reperfusion Injury;Reperfusion Therapy;Research;response;Resuscitation;Risk;risk mitigation;Scientist;shear stress;Shock;simulation environment;Stents;Sum;Techniques;Testing;Time;tool;Training;Trauma;Traumatic injury;Validation;Vena Cava Filters;Venous;Work

PROJECT_TITLE: Development of a multi-scale closed loop model for hemorrhagic shock: a platform to assess REBOA performance

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: MANGILAO

ORG_NAME: UNIVERSITY OF GUAM

ORG_STATE: GU

PI_NAMEs: LEON GUERRERO, RACHAEL T (contact)

PROGRAM_OFFICER_NAME: GHOSH, SANGEETA AHUJA

PROJECT_TERMS: Advisory Committees;anti-cancer research;Cancer Center;Cancer health equity;career development;Collaborations;Communication;community advisory board;design;Development;Educational workshop;Effectiveness;Environment;Evaluation;Goals;Guam;Hawaii;Indigenous;Infrastructure;Institution;Leadership;Malignant Neoplasms;meetings;Mission;NCI-Designated Cancer Center;Office of Administrative Management;Pacific Islander;Pacific Islands;Population;Preparation;programs;Progress Reports;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resource Sharing;Science;Services;Universities;Vision

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Individual hosts vary in their susceptibility to pathogens, which has important consequences for outbreak dynamics and pathogen evolution. Our work will elucidate relationships between prior exposure of hosts to pathogens, as occurs naturally and via vaccination, and the degree of variability in host susceptibility. The models generated will be broadly useful for understanding and managing any pathogens, including those of humans, where host protection generated by prior exposure is variable, incomplete, or wanes over time.

PI_NAMEs: HAWLEY, DANA M (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposure


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Blood malignancies are characterized by recurrent somatic mutations in RNA splicing factors that drive aberrant splicing to promote leukemogenesis. Recently, a novel species of RNA called circular RNAs (circRNA) was discovered to be aberrantly expressed in many types of liquid cancers, yet the role of RNA splicing factors mutations on the biogenesis of these molecules, if any, in promoting leukemogenesis is not known. Establishing a link between known RNA splicing factor mutations and circRNAs could define a novel regulatory axis that can be exploited for targeted therapy of these diseases.

PI_NAMEs: FERNANDEZ, MIKE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Alternative Splicing;B-Lymphocytes;Biogenesis;Biological;Biological Assay;Blood;Cancer Biology;cancer cell;cancer diagnosis;Cell Cycle Regulation;Cell Line;Cell Physiology;Cell Survival;Cells;Chemoresistance;Chronic Lymphocytic Leukemia;circular RNA;cis acting element;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Computer Analysis;CRISPR screen;Critical Pathways;Data;Detection;Development;Diagnostic;Disease;Disease Progression;Engineering;Genes;Genetic Transcription;Genomics;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;leukemia;leukemogenesis;Link;Liquid substance;Malignant lymphoid neoplasm;Malignant Neoplasms;Messenger RNA;Methods;Molecular;mutant;Mutate;Mutation;Myeloproliferative disease;novel;novel therapeutics;Output;Pathway interactions;Patients;Play;potential biomarker;Production;protein transport;prototype;Recurrence;Regulator Genes;Repetitive Sequence;Reporter;Research;RNA;RNA Splicing;RNA-Binding Proteins;Role;screening;Screening procedure;Signal Transduction;Somatic Mutation;SRSF2 gene;System;targeted treatment;Technology;Therapeutic;therapeutic target;Tissues;tool;transcriptome;tumor;tumorigenesis;U1 small nuclear RNA;United States

PROJECT_TITLE: Impact of RNA splicing factor mutations on circular RNA biogenesis in leukemia


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PI_NAMEs: WRIGHT, KENNETH LYNN (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;Basic Cancer Research;Behavior;Biometry;Bone Marrow Transplantation;Cancer Center;cancer clinical trial;cancer health disparity;cancer therapy;career;Career Choice;career development;Career Mobility;Caring;Clinical;Clinical Oncology;clinical practice;clinical training;Clinical Trials;Communities;cultural competence;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Education;education research;Educational workshop;Effectiveness;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship Program;Florida;Goals;graduate school;Grant;Health Disparities Research;health disparity;Health Sciences;Hematology;Hispanic;HIV;Immersion;improved;Industry;interest;Interest Group;investigator training;Island;Latino;Latino Population;Malignant Neoplasms;Medical;Medical Students;Mentors;Mentorship;minority health;Needs Assessment;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Participant;patient engagement;peer coaching;Persons;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;programs;Puerto Rican;Puerto Rico;recruit;Research;Research Personnel;Residencies;Rotation;Scholarship;Science, Technology, Engineering and Mathematics;Scientist;Screening for cancer;senior faculty;Series;Site;STEM research;Students;success;summer research;Surgical Oncology;Training;tumor;undergraduate student;Universities;Urology;Vision;Writing

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: This research will investigate how a protein hormone (parathyroid hormone, PTH) is able to interact with the surface of a cell in bone and transmit signals to the cell's DNA to regulate the expression of genes involved in bone breakdown. PTH is essential for maintaining serum calcium levels, but too much of the hormone or genetic diseases that act like PTH can cause major bone loss and disabilities. The results of our research will help develop treatments for hyperparathyroidism and other bone and skeletal disorders in place of surgery.

PI_NAMEs: PARTRIDGE, NICOLA C (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TITLE: Nuclear Events in PTHR1 Action on Bone


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The most recent conflicts are creating a new generation of veterans, including an increasing number of women veterans, who present with comorbid PTSD and chronic pain conditions, including Fibromyalgia (FM), from deployment-related physical injuries and exposure to psychological trauma. Health behavior change is important in treating these conditions and proactively preventing long-term negative health sequelae, in order to benefit these veterans directly and reduce the challenges to our healthcare system. The proposed SPiRE application will use an innovative translational research approach to study whether a progressive -based exercise program will reduce FM pain in patients with PTSD and to elucidate and modify potential PTSD- related deficiencies in neurobiological and psychological responses to exercise to optimize the physical and psychological benefits of exercise for these individuals.

PI_NAMEs: CHECKO (SCIOLI), ERICA ROSE (contact)

PROJECT_TERMS: actigraphy;Acute;Allopregnanolone;American;Anhedonia;Anti-Inflammatory Agents;antinociception;behavior change;Biological Markers;Boston;Cardiology;Cardiopulmonary;Chronic;chronic musculoskeletal pain;chronic pain;chronic painful condition;Clinical Research;clinically significant;Cognitive;college;comorbidity;cytokine;Data;depressive symptoms;design;Development;disability;Disease;Educational Intervention;Exercise;exercise adherence;exercise intervention;exercise physiologist;exercise prescription;exercise program;exercise regimen;Exercise Test;exercise training;experience;Exposure to;Fibromyalgia;fibromyalgia pain;fibromyalgia patients;follow-up;Fostering;Functional disorder;Funding;Generations;Grant;Guidelines;Health;Health behavior change;Health Benefit;health care service utilization;Healthcare Systems;Heart Rate;Home;Hormones;Hydrocortisone;IL8 gene;immunoregulation;improved;Individual;Inflammation;Inflammatory;Injury;innovation;Interleukin-6;Intervention;intrinsic motivation;Maintenance;Mental Depression;Mental Health;Modification;Monitor;Motivation;neurobiological mechanism;Neurobiology;Neurohormones;Neuromodulator;neuropeptide Y;neurosteroids;Pain;pain reduction;pain sensitivity;Pain Threshold;Participant;Patients;physical conditioning;Physiological;Population;Post-Traumatic Stress Disorders;Pregnanolone;prevent;Problem Solving;Process;Protocols documentation;psychologic;psychological trauma;Publishing;recruit;Research Design;response;Rewards;Running;Self Efficacy;Severities;Stress;Substance P;Symptoms;System;Telephone;Testing;Training;Training Programs;Translational Research;trauma exposure;Treatment Protocols;United States National Institutes of Health;Up-Regulation;Veterans;Walking;Woman;Work

PROJECT_TITLE: Neurobiological and Psychological Benefits of Exercise in Fibromyalgia and PTSD

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: While mothers' adverse childhood experiences (ACEs) can undermine their capacity to provide sensitive care that is essential for healthy child development, positive childhood experiences (PCEs) may be a source of resilience that buffers the deleterious effects of ACEs on parenting and their children's health. The proposed K99/R00 study aims to elucidate the relationships among mothers' ACEs and PCEs, maternal sensitivity, and immune regulation in infants and toddlers of mothers living with opioid-dependence, a high-risk group often exposed to a host of adversities. The expected findings may help explain the heterogeneity in outcomes in populations exposed to substantial adversity and will illuminate potential biobehavioral pathways of intergenerational transmission of adversity and resilience.

PI_NAMEs: YU, ZHIYUAN  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Adult;adverse childhood events;Age;Behavioral;biobehavior;Biological;biological adaptation to stress;Biological Markers;Buffers;C-reactive protein;career;Caring;Cause of Death;Cells;Child;Child Development;Child Health;child neglect;Child Rearing;Childhood;Data;Development;efficacy testing;emotion regulation;Enrollment;experience;Exposure to;Family;Foundations;Funding;Gene Expression;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Genomics;Goals;Health;Health Promotion;Heterogeneity;high risk population;Home;Immune;immune function;Immunologic Markers;immunological intervention;immunoregulation;Infant;Inflammatory;Informal Social Control;Interferon Type I;intergenerational;Intervention;Intervention Studies;Knowledge;Mediating;Mental Health;Methods;Mothers;National Institute of Child Health and Human Development;Opiate Addiction;opioid exposure;Outcome;parenting intervention;Parents;Pathway interactions;Pattern;Perinatal;Personal Satisfaction;Phase;poor health outcome;Population;prevent;promote resilience;prospective;randomized, clinical trials;Recording of previous events;Research;Research Personnel;resilience;response;Safety;Salivary;Secretory Immunoglobulin A;Shapes;skills;Source;Specific qualifier value;substance use;Testing;Time;Toddler;Training;transcriptomics;transmission process;Trauma;violence exposure;Work

PROJECT_TITLE: Mothers' childhood experiences, maternal sensitivity, and immune regulation in young children

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE The proposed research examines neurodevelopmental mechanisms underlying the powerful association of stressful life events (SLEs) with internalizing and externalizing psychopathology during adolescence. We use a novel methodological approach that permits examination of dynamic changes in emotion, cognition, social behavior, and neural function and connectivity following SLEs at a sufficiently fine grained level of temporal specificity to identify mechanisms underlying the link between SLEs and adolescent psychopathology as they unfold in real time. Elucidating these mechanisms will not only build knowledge of how environmental experience shapes development in ways that increase risk for psychopathology, but will also suggest possible targets for interventions to prevent the onset of stress-related psychopathology in children and adolescents.

PI_NAMEs: MCLAUGHLIN, KATIE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Affect;Affective;Age;Amygdaloid structure;Behavior;Behavioral;Cellular Phone;Child;Cognition;Cognitive;cognitive control;cohort;Cross-Sectional Studies;Cues;design;Development;Developmental Process;digital phenotyping;Dorsal;Emotional;emotional stimulus;Emotions;Etiology;experience;Exposure to;Female;Frequencies;Goals;Grain;improved;Individual;innovation;Institution;Institutionalization;Intervention;Knowledge;Lead;Life Cycle Stages;Link;longitudinal design;Longitudinal Studies;Maps;Measures;media use;Mediating;Mental disorders;Mental Health;Methodology;Methods;Monitor;negative affect;Negative Valence;neglect;neural;neural circuit;neuromechanism;Neurophysiology - biologic function;novel;novel strategies;Onset of illness;Pattern;peer;Performance;Physical activity;Positive Valence;prevent;Prevention;Process;prospective;Psychopathology;Research;Research Domain Criteria;response;Rest;Rewards;Risk;sex;Shapes;sleep behavior;sleep quality;sleep quantity;smartphone based device;social;Social Behavior;social engagement;social media;Social Processes;Specificity;Stress;Stressful Event;Symptoms;System;Technology;Telephone;Text;Theoretical model;Time;Variant;Ventral Striatum;Violence;wearable device;Work;Youth

PROJECT_TITLE: Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The Integrated Networks of Scholars in Global Health Research Training (INSIGHT) consortium formed between the University of Alabama at Birmingham, the Baylor College of Medicine, the University of Maryland Baltimore, and the University of Pittsburgh supports training for the next generation of global health scholars from the US and low- and middle-income countries (LMICs) through mentored research experiences at 24 established partner LM IC institutions across 19 countries in Africa, Asia, and Latin America and the Caribbean. Strong emphases are on a broad range of global health research areas, including combatting the global HIV epidemic and associated co-morbidities, emerging and re-emerging infectious diseases, non-communicable diseases, and mental health.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);MANDALAKAS, ANNA M;NIMGAONKAR, VISHWAJIT LAXMIKANT;TURAN, JANET M.

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Area;career;Educational workshop;experience;Faculty;Funding;Future;global health;International;meetings;Nature;Persons;programs;Research;Training;United States National Institutes of Health


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science

ORG_DEPT: SOCIAL SCIENCES

PI_NAMEs: KING, GARY  (contact)

PROJECT_TERMS: Adopted;Architecture;Awareness;collaborative approach;Data;Data Commons;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;Reporting;repository;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: The Harvard Dataverse repository: A generalist repository integrated with a Data Commons


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative To produce the first comprehensive 3D multiscale senescence atlas of tissues across ages, we propose to integrate our recently developed AI-based 3D tissue reconstruction platform CODA with both immunofluorescence and spatial transcriptomics, using pancreatic tissues as a testbed and expanded to breast and ovarian tissues.

PI_NAMEs: WU, PEI-HSUN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3-Dimensional;Acinus organ component;Adult;Age;age related;age-related disease;Aging;Algorithms;Architecture;Atherosclerosis;Atlases;Biological Models;Biology;Blood Vessels;Breast;Cell Aging;Cell Cycle;cell type;Cells;cohort;Complex;Cytometry;deep learning;Development;Diabetes Mellitus;digital;Duct (organ) structure;Epithelial Cells;Fatty acid glycerol esters;Fibroblasts;Heterogeneity;HMGB1 gene;Human;human disease;human tissue;Image;imaging platform;Imaging technology;Immune;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;islet;Islets of Langerhans;Label;life span;Link;Liver;Location;Lung;Lung Diseases;Mammary Gland Parenchyma;Maps;Measures;Methods;Molecular;Molecular Profiling;morphological criteria;multi-scale atlas;Natural History;Nature;Nerve;novel;Organ;Ovarian Tissue;Ovary;Pancreas;pathogen;Pathologic;Phase;Physiological;programs;Proteins;Proteomics;repaired;Resolution;response;RNA;Role;Sampling;senescence;senescent cell;Skin;Spatial Distribution;Techniques;Technology;technology platform;Thick;Three-Dimensional Imaging;Tissue atlas;tissue mapping;tissue reconstruction;Tissue Sample;Tissues;tool;transcriptomics

PROJECT_TITLE: Three-dimensional maps of senescence in the human pancreas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(70)R]


ORG_DEPT: DERMATOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Human skin, like all other tissues, undergoes an intrinsic aging process during an individual’s lifespan known as chronological aging, as well as photoaging, since the skin is constantly exposed to environmental factors such as UV radiation (UVR), which is recognized as the major risk factor for the development of many skin cancers. In the skin, there is an age-associated accumulation of senescent melanocytes, keratinocytes and fibroblasts capable of expressing the senescence-associated secretory phenotype (SASP), which promotes inflammation and have a profound deleterious effect on skin structure and integrity. We will generate 3D skin models that encompass critical biological variables for mapping senescent cells in tissues, and will include: 1) both genders; 2) the full range of skin pigmentation phototypes; and 3) age ranges across the human lifespan, to investigate the mechanisms leading to senescence in the skin and test new approaches to treat age-related conditions.

PI_NAMEs: CHRISTIANO, ANGELA M (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;Affect;Age;age group;age related;age related chronic disease;age-related disease;Aging;aging process;analytical tool;Asthma;Atopic Dermatitis;Biological;bioprinting;Bystander Effect;Cardiovascular Diseases;Cell Aging;Cell Culture Techniques;cell type;Cells;Characteristics;Chronology;Complex;Controlled Environment;cytokine;Data;Dermal;Dermis;Development;Distant;efficacy evaluation;Environment;Environmental Risk Factor;Epidermis;Evaluation;experimental study;Exposure to;Fibroblasts;Freezing;Frequencies;Gender;Generations;Genes;Goals;Heart;Histologic;Human;Hyperpigmentation;In Vitro;Individual;Inflammation;innovation;Joints;keratinocyte;Kidney;Libraries;life span;Lung;Lupus;Maps;media use;Mediating;melanocyte;Melanoma;metabolomics;Microfluidics;Modeling;multiple omics;multiplex assay;Muscle;novel drug class;novel strategies;Organ;paracrine;Paracrine Communication;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Play;Protocols documentation;Psoriasis;Psoriatic Arthritis;Psychological reinforcement;Public Health;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;sex;Skin;Skin Aging;Skin Cancer;skin disorder;Skin Physiology;Skin Pigmentation;Skin Tissue;Structure;Techniques;Testing;Time;tissue culture;Tissue Engineering;tissue mapping;Tissue Model;Tissues;tool;transcriptomics;Ultraviolet Rays;Universities;Vascular Endothelial Cell

PROJECT_TITLE: Senescence-on-a-chip: Building a microphysiological 3D skin model


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Single cell multi-omics profiling assays (e.g., single-cell RNA-seq, ATAC-seq, proteomics) have opened new windows into understanding the properties, regulation, dynamics, and function of senescence at unprecedented resolution and scale, however, these assays are inherently destructive, precluding us from tracking the molecular profiles and dynamics of live cells in tissues, whole organisms, or humans. We aim to develop an innovative technology “SenNetRaman” by combining the recent advance in high-resolution and -speed Raman microscopy, single-cell and spatial multi-omics, and machine learning to unbiasedly map the molecular and cellular heterogeneity and spatial information of senescent cells nondestructively. Overall, we believe “SenNetRaman” is highly modular and lays a foundation for future investigations into exploring single-cell genome-wide molecular dynamics of senescent cells in tissues through imaging data, in vitro and in vivo in humans.

PI_NAMEs: SO, PETER T. (contact)

PROJECT_TERMS: aged;Aging;ATAC-seq;Atlases;Biological Assay;Biological Models;Biology;Biomedical Research;Brain;Cell Aging;Cell Culture Techniques;Cell Physiology;Cells;Clinical Research;Collaborations;Complex;computational platform;computer framework;Confocal Microscopy;Data;data integration;Development;Dimensions;Disease;Dissociation;Endoscopes;Environment;Foundations;Future;Gene Expression;Gene Expression Profile;General Hospitals;Genetic Transcription;genome-wide;genomic biomarker;Genomics;Heterogeneity;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging biomarker;imaging modality;imaging system;improved;in situ sequencing;In Vitro;in vivo;Inflammatory;innovation;innovative technologies;Institutional Review Boards;Intervention;Investigation;Knowledge;Label;Life;Light;Link;lipidomics;Lung;Machine Learning;Malignant Neoplasms;Maps;Massachusetts;medical schools;metabolomics;methylomics;Microscope;microscopic imaging;Microscopy;Mission;Modeling;Molecular;molecular dynamics;Molecular Profiling;Morphology;mouse model;multimodal data;multimodality;Multiomic Data;multiple omics;Mus;New England;new technology;novel;novel marker;Pattern;Phase;predictive marker;Property;Proteomics;Protocols documentation;Raman Spectrum Analysis;Regulation;Reporting;Research Personnel;Resolution;Scanning;senescence;senescent cell;Services;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Skin;Specimen;Speed;Stress;Structure of parenchyma of lung;System;Technology;Testing;Time;tissue mapping;Tissues;Training;transcriptomics;Translations;tumor;United States National Institutes of Health;Universities;Whole Organism

PROJECT_TITLE: Single-cell label-free identification of senescence by Raman microscopy and spatial genomics


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE New technologies and experimental pipelines are needed to accurately phenotype and quantify senescent cells within their distinct microenvironments. We propose to develop iterative and integrated spatially-resolved imaging mass cytometry and digital-spatial transcriptomics for determination of senescent cell identity and abundance across mouse and human tissues, beginning with analyses in the aged mouse brain. This novel, scalable molecular mapping technology can ultimately be used to facilitate assessment of and extent to which senescent cells contribute to age-related tissue dysfunction, with broad relevance to human therapy development.

PI_NAMEs: SCHAFER, MARISSA JOY (contact)

PROJECT_TERMS: Address;Age;age related;age related decline;aged;Aging;aging mechanism;antibody conjugate;Apoptotic;Atlases;biological heterogeneity;Biological Markers;biomarker panel;Body System;Brain;brain cell;brain parenchyma;Brain region;Cell Aging;cell type;Cells;Cerebellum;Complex;Corpus striatum structure;Cytometry;Data;design;digital;Dimensions;Disease;experience;Female;Frequencies;Functional disorder;Gene Expression Profile;Goals;Health;Heterogeneity;high dimensionality;Hippocampus;Human;human tissue;Image;imaging biomarker;Individual;innovation;innovative technologies;Intervention;Knowledge;life span;male;Maps;Mediating;Metabolic;Metals;method development;Methods;Microglia;Molecular;molecular phenotype;Morphology;Mus;Neurons;new technology;novel;old mice;Pathology;Pathway interactions;Phase;Phenotype;Prefrontal Cortex;preservation;Process;programs;Property;Proteins;Regenerative capacity;Resolution;response;RNA;senescence;senescence associated secretory phenotype;senescent cell;single cell sequencing;Slice;spatial integration;Standardization;Structure of choroid plexus;Suspensions;Technology;therapeutic development;therapeutically effective;therapy development;Tissues;transcriptome;transcriptomic profiling;transcriptomics;white matter;women versus men;Work

PROJECT_TITLE: Spatially-resolved protein and transcriptome mapping of senescent cells


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: TUCSON

ORG_NAME: CRITICAL PATH INSTITUTE

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Critical Path Institute (C-Path) was established in 2005 under the auspices of FDA’s Critical Path Initiative to catalyze advances in medical innovation and regulatory science, by leading teams of stakeholders from industry, government, academia, and advocacy organizations to generate actionable solutions to address unmet needs in drug development. With renewed funding C-Path will be able to continue developing impactful Critical Path Public-Private Partnerships and advancing innovative, collaborative projects in research, education, and outreach for fostering medical product innovation, enabling the acceleration of medical product development.

PI_NAMEs: ROMERO, KLAUS  (contact)

PROGRAM_OFFICER_NAME: MUMMANENI, PADMAJA

PROJECT_TITLE: Critical Path Public Private Partnerships


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: The Wake Forest NCORP Research Base develops and implements multi-site Cancer Control and Cancer Care Delivery (CCDR) clinical research studies in partnership with NCORP Community and Minority/Underserved Community Sites to improve patient well-being and the quality of cancer care.

PI_NAMEs: DRESSLER, EMILY VAN METER;LESSER, GLENN J (contact);WEAVER, KATHRYN ELIZABETH

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acceleration;Address;Age;Aging;Area;base;Behavioral Sciences;biobank;Biological;Biometry;Blood;cancer care;cancer complication;Cancer Control;cancer health disparity;cancer site;cancer therapy;Cardiology;Cardiovascular system;care delivery;care systems;Caregivers;Caring;chemotherapy;Chemotherapy and/or radiation;clinical investigation;clinical pain;Clinical Research;Collaborations;Collection;Communities;Community Clinical Oncology Program;community partners;Comprehensive Cancer Center;Country;Data;Development;Disparity;Dissemination and Implementation;Early treatment;early-career faculty;Enrollment;ethnic minority;ethnic minority population;evidence base;Faculty;Family;Funding;Future;Goals;health disparity;Health Sciences;Health Services Research;Helping to End Addiction Long-term;Image;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;knowledge translation;Late Effects;Liquid substance;Malignant Neoplasms;medical schools;Mentors;Minority;multidisciplinary;NCI Center for Cancer Research;NCI-Designated Cancer Center;Neurocognitive;Neurosciences;next generation;novel;Oncology;Outcome;Pain;Pain management;Participant;patient oriented;patient population;Patients;Personal Satisfaction;Postdoctoral Fellow;Prevention;Primary Care;Process;protocol development;Protocols documentation;Public Health;racial minority;Radiation therapy;recruit;Research;Research Activity;Research Design;Research Personnel;research study;Resources;rural dwellers;Salivary;Sampling;Science;Site;Specimen;Speed;Students;Supportive care;survivorship;Symptoms;Toxic effect;Training;Treatment Efficacy;Treatment outcome;underserved community;underserved minority;Underserved Population;United States National Institutes of Health;Urine;Woman;Work

PROJECT_TITLE: Wake Forest NCORP Research Base


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

PHR: NARRATIVE  Although the intrauterine setting is considered to be a safe environment for the fetus, microbes have been detected in gestational tissues in normal asymptomatic pregnancies. The proposed studies in this grant address novel and cutting-edge concepts regarding the role of placenta-specific microRNAs in regulating exaggerated inflammation after repeated infections during pregnancy. These studies may set the stage to the identification of biomarkers and targets to treat inflammation related to preterm births and other inflammation-associated pathologic pregnancies.

PI_NAMEs: HANNA, NAZEEH N (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Attenuated;Bacterial Toxins;Biological Markers;biomarker identification;candidate marker;cell type;Cells;Clinical;Data;Disease;Distant;Dose;Down-Regulation;Endometrial;Environment;Equilibrium;Exhibits;experimental study;Exposure to;extracellular vesicles;fetal;Fetus;Future;Grant;healthy pregnancy;Histologic;Host Defense;Human;human disease;Immune;Immune response;Immune system;Immune Tolerance;Immunosuppression;implantation;Infection;Inflammation;Inflammatory;Inflammatory Response;intraamniotic infection;intrauterine environment;Invaded;Link;Maintenance;Maternal-Fetal Exchange;Mediating;Microbe;MicroRNAs;Modeling;Molecular;mortality;Mothers;Mus;novel;Organism;pathogen;pathogenic microbe;Pathologic;Phenotype;Placenta;placental trophoblasts;Placentation;Play;Pregnancy;Pregnancy Trimesters;Pregnant Women;Premature Birth;prevent;Production;Research;Role;Signal Transduction;Stimulus;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;Uterine Contraction;Woman

PROJECT_TITLE: Placenta-specific miR-519c-mediated induction of immune tolerance in human placenta

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: This project will leverage and pivot UCSF’s significant expertise, experience, and capacity in community-engaged research, disparities research, program implementation experience with populations that are underserved and vulnerable, data science, and major chronic diseases to create a nationwide research coordinating center and technical assistance center to support a network of NIMHD funded P50 centers to reduce multiple chronic disease related disparities in underserved and vulnerable populations.

PI_NAMEs: CHARLEBOIS, EDWIN DUNCAN;GANSKY, STUART A (contact);RHOADS, KIM FELDER

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Acceleration;Affect;African American;Alaska Native;Artificial Intelligence;Asian;Awareness;biomedical informatics;California;Case Study;Chronic;Chronic Disease;Cities;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Collection;Common Core;Common Data Element;Communication;Communities;community advisory board;community engaged research;community engagement;Community Networks;Community of Practice;community partners;community partnership;comorbidity;Country;COVID-19;Data;Data Aggregation;data management;Data Science;Data Set;data sharing;data standards;data warehouse;design;Development;disease disparity;Disparity;disparity reduction;Education;education research;Educational workshop;Evaluation;experience;flexibility;Funding;Geography;Goals;Health;health data;Health Disparities Research;health disparity populations;Health Sciences;Hispanic;Homelessness;human subject;implementation science;Individual;instrument;Integrated Health Care Systems;interoperability;Intervention;Intervention Trial;Latino;meetings;member;Mentors;Methods;minority health;minority health disparity;Minority-Serving Institution;Monitor;National Institute on Minority Health and Health Disparities;Native Americans;Neighborhoods;operation;Pacific Islander;Persons;PhenX Toolkit;Population;prevent;Prevention;Process;programs;Race;Records;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;responsible artificial intelligence;Risk;San Francisco;Secure;Sexual and Gender Minorities;Site;skill acquisition;skills;social health determinants;socioeconomics;Standardization;Statistical Data Interpretation;Testing;tool;Training;Underserved Population;United States National Institutes of Health;Universities;Vulnerable Populations;web site;webinar;working group

PROJECT_TITLE: Research Coordinating Center to Reduce Disparities in Multiple Chronic Diseases (RCC RD-MCD)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Thailand remains one of the countries with the largest population of people living with HIV (PLWH) in the Asian-Pacific region. In Thailand, as in other middle-income Asian countries, HIV stigma has been impacted in PLWH and their family members is a pressing health concern. The purpose of this study is to culturally adapt and evaluate the feasibility of a 4 weekly 2-hour group-based stigma reduction intervention to promote health engagement.

PI_NAMEs: CHEN, WEI-TI  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Affective;arm;Asia;Asian;Behavior;Belief;Buddhism;Caring;Cognitive;Compassion;Country;culturally appropriate intervention;Data;Death Rate;Deterioration;Discrimination;Epidemic;ethnic minority;evidence base;Family member;feasibility testing;Future;gender minority;Goals;Health;health care availability;Health Promotion;Health Services;HIV;Hour;Image;Income;Individual;innovation;insight;internalized stigma;Intervention;Intervention Studies;Interview;Manuals;marginalization;Measures;men who have sex with men;Mental Health;Methods;mindfulness;Modeling;Modernization;Myanmar;operation;Outcome;Outcome Assessment;Participant;Pathway interactions;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Philosophy;physical conditioning;Pilot Projects;Population;Prevalence;primary outcome;Procedures;Process;protective behavior;Protocols documentation;psychoeducation;Randomized;Randomized, Controlled Trials;Research;Risk Factors;Role;Sampling;secondary outcome;Self Management;self-compassion;sex;Sexual and Gender Minorities;social;social stigma;Social support;substance user;Thailand;transgender;Treatment Efficacy;treatment group;Underserved Population;United States;Viral Load result;Woman

PROJECT_TITLE: Buddhism and HIV Stigma in Thailand: An Intervention Study

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: PROJECT NARRATIVE In this application, I propose a set of genetic, biochemical and bioinformatics studies to understand: 1) the role of ADAR1 RNA editing in regulation of the maternal transcriptome in the oocyte and early embryo in young and old mice, and 2) the effect of ADAR1 RNA editing on RNA stability in oocytes and eggs from young and old mice. These mechanistic studies will advance our basic understanding of how post-transcriptional RNA processing is integral to the oocyte RNA environment, and hence, oocyte quality. The knowledge gained from this proposal could promote a shift in current paradigms and redirect research to accelerate progress in understanding infertility and disease.

PI_NAMEs: BRACHOVA, PAVLA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adenosine;adenosine deaminase;age related;age related decline;aging population;Area;Biochemical;Bioinformatics;blastocyst;Cells;Code;Codon Nucleotides;Competence;Congenital Abnormality;Coupled;Data;Deamination;decapping enzyme;Defect;Development;Disease;dosage;Double-Stranded RNA;dsRNA adenosine deaminase;egg;Embryo;Embryonic Development;Environment;Enzymes;experimental study;Female;female fertility;Fertility;Fluorescent in Situ Hybridization;Genetic;Genetic Transcription;Goals;Growth;Human;human embryonic development;Infertility;innovation;Inosine;Knock-out;Knowledge;male;Maternal Age;Maternal Messenger RNA;Mediating;Meiosis;Mentors;Mentorship;Messenger RNA;Modeling;Modification;Morula;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;Mus;mutant;novel;old mice;oocyte quality;Oocytes;Oogenesis;Partner in relationship;Pattern;Phase;Poly(A) Tail;Polyribosomes;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Process;Proteins;recruit;Regulation;Reproduction;reproductive;Research;RNA;RNA Editing;RNA Stability;Role;Scientist;spleen exonuclease;Spontaneous abortion;Testing;Training;Transcript;transcriptome;transcriptomics;Translations;Work;zona pellucida glycoprotein

PROJECT_TITLE: A-to-I RNA modifications in mouse oocytes


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE The ultimate goal of this research is to evaluate the feasibility, acceptability and preliminary impact of incorporating choice in the delivery of ART support to patients who return to HIV care after an interruption, a growing population who are vulnerable to future interruptions. The development of patient-centered interventions is a key priority area to bridge remaining HIV treatment gaps in high-burden settings like South Africa. If proven to be acceptable, feasible and effective, incorporating choice in the delivery of ART support in routine, high-burden HIV care settings may be an important tool to promote patient empowerment and improve ART adherence and retention.

PI_NAMEs: PHILLIPS, TAMSIN KATE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adult;Africa South of the Sahara;Aftercare;AIDS prevention;antiretroviral therapy;Area;arm;Attention;Award;behavior measurement;Behavioral;behavioral and social science;behavioral economics;Behavioral Research;career;career development;Caring;Clinic;Clinical;Communities;Contraceptive Agents;Data;design;Development;Effectiveness;Effectiveness of Interventions;empowerment;Ensure;Epidemiologist;Epidemiology;Evaluation;evidence base;experience;experimental study;Family Planning;Fellowship;Funding;Future;gender behavior;Goals;Growth;Guidelines;Health;Health behavior;Health Services;high risk;HIV;HIV/AIDS;implementation measures;implementation science;improved;Individual;informant;innovation;International;Interruption;Intervention;Intervention Studies;Interview;Investigation;K-Series Research Career Programs;Leadership;Measurement;Measures;men;Mentors;Mentorship;Methods;mHealth;mhealth interventions;multidisciplinary;North Carolina;Outcome;Output;patient oriented;Patient Preferences;Patients;peer support;Pennsylvania;Persons;pilot trial;Policies;poor health outcome;Population;Postdoctoral Fellow;preference;Public Health;Qualitative Methods;Qualitative Research;Randomized;Research;Research Methodology;Research Personnel;Research Priority;Resources;Role;satisfaction;Scientist;secondary outcome;Self Efficacy;Series;Services;skills;social;South Africa;Structure;Surveys;therapy adherence;therapy design;therapy development;Time;tool;Training;Treatment outcome;United States National Institutes of Health;Universities;Viral;Woman

PROJECT_TITLE: Zikhethele - choose for you: evaluating choice-based antiretroviral therapy support for patients returning to HIV care after treatment interruption in South Africa


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PI_NAMEs: SAWYER, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Acute;acute care;Advisory Committees;Antibiotic Therapy;Area;Basic Science;Bioethics;Biomedical Research;Cardiopulmonary Resuscitation;Cardiovascular system;care outcomes;care systems;career;Caring;Centers of Research Excellence;Clinical;clinical center;Clinical Research;cohort;Collaborations;Communication;community engagement;community engagement process;Community Hospitals;Community Outreach;Consent;Core Facility;design;Development;Discipline;Disparity;disparity reduction;Doctor of Philosophy;Emergency Situation;Ensure;Ethics;Evaluation;Exhibits;experience;Face;Family;Fostering;Funding;Goals;Growth;Health Personnel;Health Services Research;Healthcare;Healthcare Systems;Heart Arrest;Human Subject Research;improved outcome;Inflammatory Response;Infrastructure;innovation;Institution;Investments;Leadership;Learning;Link;Maine;Medical;Medical center;meetings;Mentors;Mentorship;Modeling;Molecular Analysis;National Institute of General Medical Sciences;neonatal encephalopathy;neonate;New England;organizational structure;outcome disparities;outreach;Patients;Physicians;Pilot Projects;Principal Investigator;Process;Program Development;Program Evaluation;programs;prophylactic;Reporting;Research;Research Methodology;Research Personnel;Research Training;Rural;rural area;Rural Community;rural disparities;rural health disparities;rurality;Scientist;Severities;Strategic Planning;Structure;success;synergism;System;Teacher Professional Development;Telemedicine;Translational Research;translational research program;United States National Institutes of Health;urban area;urgent care

PROJECT_TITLE: Administrative and Professional Development Core


NIH_SPENDING_CATS: Aging;Women's Health Research

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Advisory Committees;Aging;Annual Reports;Attention;Basic Science;Biological;BMP2 gene;career development;Clinical Research;Collaborations;Communication;Communities;Complex;Cues;Data;Delaware;Development;Development Plans;Disease;Ensure;Evaluation;Extramural Activities;Faculty;formative assessment;Functional disorder;Funding;Future;Goals;Grant;Growth;Health;improved;Infrastructure;Leadership;meetings;Mentors;Musculoskeletal;Musculoskeletal Diseases;novel;Office of Administrative Management;operation;Periodicals;pre-clinical;pre-clinical research;Program Development;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Signal Transduction;Structure;success;Therapeutic Intervention;Tissues;tool;United States National Institutes of Health;Universities;Women's Health;Work

PROJECT_TITLE: Delaware Center for Musculoskeletal Research – Administrative Core