NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Hematology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

PHR: Relevance  Studies proposed in this Program will advance our understanding of how proteins present on the surface of human blood platelets become unintentional targets of the immune system, leading to a devastating bleeding disorder in fetuses and neonates. We will also examine how a functionally-important receptor that forms the glue between the cells that line our blood vessels regulates the movement of blood cells and fluids into and out of underlying tissues during conditions of acute and chronic inflammation. The novel animal models and tools that will be developed as a result of this broad and ambitious Program will lead to new diagnostics and novel personalized therapeutics for treating diseases of the blood.

PI_NAMEs: NEWMAN, PETER J (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acute;Adhesives;Affinity;Animal Model;Antigen Presentation;Binding;biological adaptation to stress;Blood;Blood Cells;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;CD31 Antigens;Cell Adhesion;Cell Line;Cell Physiology;Cells;Cellular biology;Cessation of life;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cryopreservation;design;Development;Diagnosis;Diagnostic;diagnostic platform;Disease;Endothelial Cells;Extravasation;fetal;Fetus;Functional disorder;Future;gene editing technology;Glues;Hematological Disease;Human;Human Platelet Antigens;humanized mouse;Immune system;Immune Targeting;improved;induced pluripotent stem cell;Infant;Inflammation;Inflammatory;Inherited;innovation;Intercellular Junctions;interest;Intracranial Hemorrhages;Investigation;isoimmunity;Lifelong disability;Liquid substance;Maternal antibody;Megakaryocytes;Mission;Modeling;Molecular Biology;Molecular Conformation;mouse model;Movement;National Heart, Lung, and Blood Institute;Neonatal;Neonatal Alloimmune Thrombocytopenia;neonatal care;neonate;new therapeutic target;novel;novel diagnostics;PECAM1 gene;personalized therapeutic;Placenta;Principal Investigator;programs;Proteins;receptor;receptor function;Receptor Signaling;Reperfusion Injury;Research;response;restoration;Role;self-renewal;Sepsis;Series;Source;Speed;stem cells;Surface;Technology;Therapeutic;three dimensional structure;Thrombocytopenia;thrombotic;Tissues;tool;Transfusion;translational applications;Vascular Diseases;Vascular Permeabilities

PROJECT_TITLE: Basic Investigation and Translational Applications Concerning the Cell and Molecular Biology of Blood and Vascular Cells


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The only documented cures of HIV/AIDS involve intensive chemotherapy and transplantation with hematopoietic stem/progenitor cells (HSPC) that are genetically resistant to HIV-1 infection. Chemotherapy itself does little to HIV, but adds toxicity. The beneficial effect of the transplant is likely due to the regeneration of an HIV-resistant immune system. This proposal combines methods of reducing transplant conditioning toxicity, engineering HIV resistant HSPC and improving immune regeneration. This project tests a recently developed method of improving T cell regeneration in transplantation to augment immune reconstitution and viral reservoir targeting using engineered HSPC.

PI_NAMEs: SCADDEN, DAVID T (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Adaptive Immune System;Allogenic;Animals;Anti-HIV Therapy;Antibodies;Antibody-drug conjugates;antiretroviral therapy;aspirate;Autologous;Award;Biomedical Engineering;Biotechnology;BMP2 gene;Bone Marrow;CCR5 gene;cell regeneration;Cell Transplantation;cell type;Cells;chemotherapy;Collaborations;Common Lymphoid Progenitor;Communication;Competence;Complement;Complex;conditioning;cryogel;Development;Disease;Doctor of Philosophy;engineered stem cells;Engineering;Gene Modified;Generations;Genes;Grant;Growth Factor;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;HIV;HIV Infections;HIV resistance;HIV-1;HIV/AIDS;Human;Human immunodeficiency virus test;humanized mouse;Immune;immune function;immune reconstitution;Immune system;Immunity;Immunocompetence;Immunocompetent;Immunologics;improved;Individual;Infection;Injections;Intervention;Laboratories;Ligands;Lymphopoiesis;Mature T-Lymphocyte;Methods;Modeling;mouse model;Mus;Natural regeneration;Nature;Needles;nonhuman primate;notch protein;novel;Organ;Osteoblasts;Osteocalcin;osteogenic;Participant;Patients;post-transplant;pre-clinical;Preclinical Testing;Primates;Process;Production;progenitor;Provider;PTPRC gene;Publishing;Reagent;Resistance;Resources;Rosaniline Dyes;stem cell self renewal;stem cells;Stromal Cells;subcutaneous;Subcutaneous Injections;success;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;thymocyte;Thymus Gland;Time;Tissues;Toxic effect;Transplantation;Transplantation Conditioning;Viral reservoir;Viremia;Work

PROJECT_TITLE: Enhancing regeneration of stem cell-derived HIV-specific immune effectors


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Genetics;Hematology;Osteoporosis;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: Project Narrative and Relevance to Public Health Our proposed work will perform high resolution peripheral quantitative computed tomography scans in over 3,000 Framingham 3rd Generation participants to determine: 1) the role of metabolomics in age-related bone loss and fractures; and 2) to determine if clonal hematopoiesis of indeterminate potential contributes to bone density, microarchitecture and strength. Discoveries related to these aims may identify targets for therapeutic interventions to prevent skeletal deterioration and fractures, which will prevent mortality, morbidity and disability. Fracture prevention will also reduce economic costs of health care required to care for these injuries. 1

PI_NAMEs: KIEL, DOUGLAS P. (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acceleration;Address;age related;age related changes;age related decline;Age-Related Bone Loss;Biological Markers;Body System;bone;Bone Density;bone loss;bone strength;Candidate Disease Gene;Caring;clinical practice;clinical risk;cohort;Cohort Studies;Coronary heart disease;cortical bone;Data;Deterioration;Diagnostic;disability;Distal;DNMT3a;drug development;Drug Targeting;Dual-Energy X-Ray Absorptiometry;economic cost;epidemiology study;follow-up;Forearm;Fracture;fragility fracture;Future;Gene Mutation;Generations;Genes;Genetic;genetic variant;genome sequencing;Goals;Health Care Costs;Hematologic Neoplasms;Hematology;Hematopoiesis;hematopoietic stem cell self-renewal;high resolution imaging;Human;Incidence;indexing;Individual;Injury;insight;JAK2 gene;Knowledge;Longitudinal Studies;Measures;member;Mendelian randomization;metabolomics;Methods;Molecular;molecular marker;Morbidity - disease rate;mortality;Mus;Mutation;novel;offspring;Osteoporosis;Participant;Pathogenesis;Pathway interactions;Peripheral;Plasma;Porosity;Prevalence;prevent;Prevention;Procedures;Proxy;Public Health;reduced muscle mass;Research;Resolution;Risk;Risk Factors;Role;Sampling;Scanning;skeletal;Skeleton;Somatic Mutation;stem cell population;STEM research;substantia spongiosa;System;targeted sequencing;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Thinness;tibia;Time;Trans-Omics for Precision Medicine;whole genome;Work;X-Ray Computed Tomography

PROJECT_TITLE: Novel Molecular Biomarkers of Bone Microarchitecture

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


PHR: Narrative  Hematopoietic stem cell transplantation may offer a curative strategy for HIV. However, current conditioning is highly toxic and often precludes transplant in non-life-threatening settings. By developing safer and targeted methods of nongenotoxic conditioning, we aim to lower the barrier to transplant and expand the use of curative transplant in HIV.

PI_NAMEs: RAFFEL, GLEN D (contact)

PROJECT_TERMS: Acute;Address;Adopted;Allogenic;Animals;Antibody-drug conjugates;antiretroviral therapy;Autologous;Autologous Transplantation;Berlin;BLT mice;CCR5 gene;cell regeneration;Cell Transplantation;Cells;cellular development;chemokine receptor;chimeric antigen receptor;Chimerism;Chronic;clinical application;Clinical Trials;Collaborations;Complication;conditioning;delta receptors;Development;Disease;disorder control;Donor person;Dose;engineered stem cells;Engineering;Engraftment;Environment;experience;Frequencies;gene editing technology;Gene Modified;Generations;Genes;Genetic Recombination;Goals;graft vs host disease;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;HIV;HIV Infections;HIV/AIDS;Hospitalization;Immune;immune reconstitution;Immune system;Immunity;immunodeficiency;improved;Infection;Institution;Intervention;Lead;Life;London;Macaca mulatta;Malignant Neoplasms;Marrow;Methods;Modeling;Morbidity - disease rate;neutralizing antibody;Non-Malignant;novel;Patients;Population;preclinical development;preservation;Process;Property;Proto-Oncogene Protein c-kit;PTPRC gene;Reagent;Regimen;Resistance;Resources;Rhesus;Schedule;simian human immunodeficiency virus;stem cell engraftment;stem cell exhaustion;stem cell niche;Stem cell transplant;stem cells;success;T-Lymphocyte;Toxic effect;Transplantation;trial planning;Viral;Viral reservoir;Virus;Withdrawal;Work

PROJECT_TITLE: Nongenotoxic conditioning for HIV cure transplantation approaches


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunization;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Sickle Cell Disease;Vaccine Related

ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF GHANA

PHR: PROJECT NARRATIVE The proposed research project aims to understand the epidemiology of Streptococcus pneumoniae with respect to children with sickle cell disease in the era of pneumococcal conjugate vaccines. The methods involve longitudinal carriage studies and surveillance of invasive pneumococcal disease. Information generated from the project would be useful in designing preventive and management strategies to protect children with sickle cell disease against pneumococcal infections.

PI_NAMEs: SAMPANE-DONKOR, ERIC  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Address;Africa South of the Sahara;African;aged;Antibiotic Prophylaxis;Antibiotics;Area;Bacteria;Child;Conjugate Vaccines;Control Groups;Country;Data;design;Development;Disease;Encapsulated;Epidemiology;Evaluation;Frequencies;Future;Ghana;Goals;High Prevalence;Immune system;Incidence;insight;Measures;Methods;Monitor;Multi-Drug Resistance;Nasopharynx;Organism;Patients;Penicillin Resistance;Penicillins;Persons;Pneumococcal conjugate vaccine;Pneumococcal Infections;Polysaccharides;Population;Populations at Risk;Predisposition;Prevalence;Prevention;Preventive;prophylactic;Prophylactic treatment;Recommendation;Research Project Grants;Serotyping;Sickle Cell Anemia;Streptococcus pneumoniae;success;surveillance data;transmission process;Upper respiratory tract;Vaccinated;Vaccination;vaccine trial;Vaccines

PROJECT_TITLE: Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Genetic modification of hematopoietic stem and progenitor cells is being considered as a way to mimic elements of the Berlin Patient cure. In this proposal we will enhance the efficiency and safety of modifications based on genome engineering and evaluate combinations of approaches that could be combined to suppress HIV and achieve a cure.

PI_NAMEs: CANNON, PAULA M (contact)

PROJECT_TERMS: Adoptive Transfer;Antibodies;Antigens;Autologous;B-Lymphocytes;Berlin;Binding;CCR5 gene;CD4 Positive T Lymphocytes;Cell Line;Cell Physiology;Cell Transplantation;Cells;Cellular biology;Collaborations;combinatorial;differentiation in vitro;DNA;DNA cassette;DNA Repair;Elements;engineered stem cells;Engineering;Engraftment;Evolution;experience;gain of function;gain of function mutation;Gene Combinations;gene repair;gene therapy;gene-editing approach;Generations;Genes;Genetic;Genome engineering;Hematopoietic;hematopoietic engraftment;Hematopoietic stem cells;HIV;HIV Infections;HIV resistance;Human;humanized mouse;IgG1;Immune;Immune response;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulins;improved;Individual;inhibitor;Knock-out;Macaca;Macaca mulatta;Mediating;Membrane;Methods;mimetics;Modification;mouse model;Mus;nanobodies;neutralizing antibody;Nonhomologous DNA End Joining;novel;nuclease;Outcome;Pathway interactions;Patients;Peripheral;plasma cell differentiation;predictive tools;Production;Reagent;repaired;Safety;Series;Signal Transduction;Site;stem cells;T-Cell Depletion;targeted nucleases;Technology;Time;Transplantation;V(D)J Recombination;Vaccination;Viral;Viremia

PROJECT_TITLE: Combination gene editing for local and systemic HIV resistance


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE HIV-1 persists in viral reservoirs throughout the body, even during suppressive antiretroviral therapy (ART). Because latent virus may appear months or years after ART is withdrawn, an effective anti-HIV strategy must likewise persist indefinitely. In this project, our goal is to enable long-term remission of HIV-1 by seeding gene- modified cell products that will persist life-long, and act as sentinels against reactivated virus.

PI_NAMEs: KIEM, HANS-PETER  (contact)

PROJECT_TERMS: Address;Alleles;Allogenic;Animal Model;Animals;antibody mimetics;antiretroviral therapy;Autologous;Autopsy;B-Lymphocytes;Bar Codes;Berlin;Binding;Bone Marrow;Boston;Brain;CCR5 gene;CD4 Antigens;Cell Transplantation;cell type;Cells;Cellular Immunity;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;conditioning;cryogel;Data;deep sequencing;delta receptors;design;Development;Disease remission;DNA Repair Pathway;Dose;engineered stem cells;Engraftment;experience;Experimental Designs;experimental study;Flow Cytometry;gene editing technology;Gene Modified;gene therapy;Genes;Genetic;Genetic Engineering;Goals;hematopoietic differentiation;Hematopoietic stem cells;HIV;HIV Infections;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunohistochemistry;Impairment;improved;in vivo;Infection;Infusion procedures;inhibitor;interest;Kinetics;Letters;London;lymph nodes;Measures;Methodology;Methods;Mississippi;Modeling;Mutate;neutralizing antibody;news;Nonhomologous DNA End Joining;nonhuman primate;novel;Oligonucleotides;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Population;preference;Property;Protocols documentation;rational design;receptor;Rectum;Regimen;repaired;Resistance;resistance gene;response;Rosaniline Dyes;scaffold;Sentinel;simian human immunodeficiency virus;Site;Source;stem cell engraftment;stem cell expansion;stem cell genes;Stem cell transplant;stem cells;synergism;T-Lymphocyte;Therapeutic;therapeutic transgene;Time;Tissues;trafficking;Transgenes;Viral;Viral reservoir;Viremia;Virus;Virus Activation;Virus Diseases;Virus Latency;Whole-Body Irradiation;Work

PROJECT_TITLE: Nongenotoxic conditioning to enhance stem cell engineering and virus-specific immunity in nonhuman primates


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Addiction is a major public health concern as it affects millions of individuals afflicted with the disorder, and has negative consequences for society at large. Great advances have been made in understanding the actions of drugs of abuse on the brain, but much remains to be learned. The purpose of this training grant is to foster interest in addiction among graduate students supported, such that these students will devote their research and eventually their careers to the study of the neurobiological bases of addiction and development of effective treatments.

PI_NAMEs: FLAGEL, SHELLY BETH (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: National Institute of Drug Abuse;Neurosciences;Training Programs

PROJECT_TITLE: NIDA Training Program in Neuroscience


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Risks of complications and death for adolescents and young adults (AYA) with sickle cell disease (SCD) increase dramatically following the transition from pediatric to adult care. To reduce these risks, it is critical that AYA with SCD develop self-management skills prior to transition to adult care; however, easily accessible tools to assist with SCD self-management skills development are scarce. This study will support the testing of a web-based application (app) that provides AYA with SCD with tools and resources to develop self-management skills that can reduce risks of complications and death.

PI_NAMEs: PHILLIPS, SHANNON M. (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: acute care;Address;Adolescent and Young Adult;Adoption;Adult;Affect;Age;Anxiety;Behavior;behavioral outcome;Benchmarking;Biological;Body System;Caring;Cessation of life;Characteristics;Child;Childhood;Chronic;Clinic;Clinical;clinical care;Communities;comorbidity;complex chronic conditions;Consolidated Framework for Implementation Research;Data;design;Development;Disease;Education;Educational Materials;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Electronics;enhanced care;Enrollment;evidence base;experience;Face;Family;feasibility testing;future implementation;group intervention;Health;health care service utilization;health care settings;health equity;Health Promotion;Healthcare;Hydration status;implementation barriers;implementation facilitators;implementation intervention;improved;Individual;Intervention;Interview;medication compliance;Mental Depression;mHealth;mHealth self-management;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;National Institute of Nursing Research;Neurocognitive;Nurses;Nursing Research;Outcome;Outpatients;Pain;Pain interference;Pain management;Parents;Participant;patient-clinician communication;Patients;Policies;Population;post intervention;Prevention;primary outcome;Process;Provider;psychosocial;Psychosocial Factor;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;Resources;Risk;Risk Reduction;Role;Sampling;secondary analysis;secondary outcome;Self Management;Severity of illness;Sickle Cell Anemia;Site;skill acquisition;skills;social;Social Environment;social stigma;Strategic Planning;Structure;Surveys;Symptoms;Testing;theories;tool;transition to adulthood;Treatment Protocols;Voice;web app;young adult;Youth

PROJECT_TITLE: Self-Management for Youth Living with Sickle Cell Disease (SMYLS)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project aims at developing novel human cGAS inhibitors for targeting maladaptive immune responses in tauopathy models of Alzheimer's disease. This study may provide proof of concepts and afford novel lead compounds for further development.

PI_NAMEs: GAN, LI ;SINHA, SUBHASH C (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: ABCB1 gene;Ablation;Agonist;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;analog;Anti-viral Response;Behavior;behavior test;beta amyloid pathology;Biochemical;Biological;Biological Assay;Brain;Cells;Cerebrum;Chronic;Clinical Trials;Cognitive deficits;Coupling;Cyclic GMP;cytokine;Dementia;design;Development;Disease;DNA;Docking;drug candidate;drug discovery;Drug Kinetics;Drug Targeting;ds-DNA;efficacy study;Elderly;Evaluation;Exhibits;experimental study;Generations;Genes;Genetic;Genetic study;Gliosis;Goals;Guanosine Triphosphate;Hippocampus;Histology;Human;Human Genetics;human stem cell-derived;hyperphosphorylated tau;Immune;Immune response;Impaired cognition;improved;in silico;In Vitro;in vivo;in vivo evaluation;Inflammatory;inhibitor;Innate Immune Response;Interferon Activation;Interferon Type I;Interferon-beta;Interferons;Late Onset Alzheimer Disease;Lead;Learning;Ligands;Link;Liver;Liver Microsomes;luminescence;Measures;Mediating;Memory impairment;Memory Loss;Metabolic;Metabolism;Microglia;Microsomes;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;nanomolar;Nervous System Disorder;Neurofibrillary Tangles;neuroinflammation;Neurons;neurotoxic;next generation;novel;novel lead compound;Organoids;overexpression;Pathologic;Pathology;Pathway interactions;Permeability;Pharmaceutical Preparations;Phase;Plasma;Play;preclinical study;Preclinical Testing;preference;Production;Property;protective effect;Proteins;response;Risk;risk variant;Role;Screening Result;Second Messenger Systems;Senile Plaques;sensor;Signal Transduction;small molecule;small molecule inhibitor;Source;Stimulator of Interferon Genes;Structure;Structure-Activity Relationship;success;Synapses;tau mutation;tau Proteins;Tauopathies;therapeutic target;Tissues;tool;Toxic effect;transcriptomics;Viral;Wild Type Mouse

PROJECT_TITLE: cGAS inhibitors for Alzheimer's disease treatment

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Alzheimer’s disease (AD) is a major public health crisis with no available cure. We propose innovative translational big data analytic methods to improve our understanding of the genetic, molecular and neurobiological mechanisms of AD, facilitate the identification of novel promising targets and drugs for repurposing, and ultimately have a translational impact on disease treatment and prevention. The resulting methods are also expected to impact biomedical research in general and benefit public health outcomes.

PI_NAMEs: KIM, DOKYOON ;NING, XIA ;SHEN, LI  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;analytical method;analytical tool;anti-cancer research;Area;Big Data;Big Data Methods;Bioinformatics;Biological Markers;biomarker discovery;biomarker driven;Biomedical Research;candidate identification;Cells;Clinical;Clinical Data;clinical phenotype;Clinical Trials;Cognitive;cohort;Communities;Complex;cost;Coupled;Data;data integration;data resource;Databases;deep learning;Dimensions;Disease;disease model;drug candidate;Drug Combinations;drug development;drug discovery;drug repurposing;druggable target;early detection biomarkers;Early Diagnosis;Electronic Health Record;Failure;Genes;Genetic;Goals;graph neural network;Image;improved;Individual;Informatics;informatics tool;innovation;Knowledge;Knowledge Portal;Liquid substance;Machine Learning;Medicine;Methods;Molecular;Multimodal Imaging;Multiomic Data;multiple omics;Network-based;neurobiological mechanism;novel;novel strategies;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic data;population based;Positioning Attribute;prevent;Prevention;Proteins;Psychological reinforcement;Public Health;Research;Research Project Grants;response;Signal Transduction;success;System;Therapy Clinical Trials;tool;Toxic effect;transcriptome;Translating;translational impact;Validation;virtual;Walking

PROJECT_TITLE: Translational big data analytic approaches to advance drug repurposing for Alzheimer's disease


NIH_SPENDING_CATS: Immunotherapy;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative We recently find that B-1a cells in neonatal thymus interact with CD4+ thymocytes and differentiate to Aire+ antigen-presenting cells, which select a neonatal Treg population that confers B cell-tolerance. Studies here will determine this B cell-tolerance induction mechanism that is mediated by B-1a and Treg cells in neonatal thymus

PI_NAMEs: HERZENBERG, LEONORE A. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Ablation;Adult;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigen-Presenting Cells;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactivity;B cell reconstitution;B-Lymphocytes;Birth;Bone Marrow;CD4 Positive T Lymphocytes;CD5 Antigens;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;CTLA4 gene;CTLA4 haploinsufficiency;Cues;Development;fetal;FOXP3 gene;Generations;Helper-Inducer T-Lymphocyte;Housekeeping;humoral immunity deficiency;Immune;immune self tolerance;Immune Tolerance;Immunoglobulin M;Impairment;inhibitor;insight;Invaded;Life;Maintenance;man;Mediating;Molecular;Mus;natural antibodies;Neonatal;neonatal mice;neonate;pathogen;Peripheral;Phenotype;Play;Population;progenitor;Proliferating;Regulatory T-Lymphocyte;Reporting;Role;Self Tolerance;Signal Transduction;SLAM protein;Spleen;Structure of germinal center of lymph node;Surface;T-Cell Activation;T-Lymphocyte;Testing;thymocyte;Thymus Gland;Tissues;TNFRSF5 gene;TNFRSF6 gene

PROJECT_TITLE: Aire-dependent thymic B-1a cells play a key role in neonatal tolerance induction

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Obesity is typically associated with a constellation of metabolic abnormalities and diseases, including dyslipidemia, insulin resistance, and type 2 diabetes. However, not all individuals with obesity develop these complications; some have a higher propensity for the adverse metabolic effects of excess adiposity. This proposal focuses on identifying how the gut microbiota and the immune system drive the heterogeneity of metabolic abnormalities in individuals with obesity.

PI_NAMEs: KULKARNI, DEVESHA  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipose tissue;Affect;Antigens;bacterial community;Bioinformatics;Biology;Body Composition;Body Weight;career development;Cells;Complement;Consumption;cytokine;Data;Dendritic Cells;Development;Development Plans;Diet;Disease;dysbiosis;Dyslipidemias;Ecology;Energy Metabolism;Enterobacteriaceae;Environment;experience;Fatty acid glycerol esters;Flow Cytometry;Fostering;Gene Expression;Genetic;Glucose Intolerance;Goals;Goblet Cells;gut microbes;gut microbiome;gut microbiota;Gut Mucosa;Heterogeneity;host-microbe interactions;Human;human subject;humanized mouse;Immersion;Immune;Immune system;Immune Tolerance;Immunology;improved;Individual;Infection;Infiltration;Inflammation;Inflammatory;inflammatory marker;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Intestines;Knowledge;Lipids;Liver;Macrophage;Manuscripts;Measures;member;Mentored Research Scientist Development Award;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Methods;Microbe;microbial;microbiota;Mission;Modeling;monocyte;Mononuclear;mouse model;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pathogenesis;Persons;Phagocytes;pharmacologic;Phenotype;photoactivation;Plasma;Plasminogen Activator Inhibitor 1;post-doctoral training;Principal Investigator;programs;Proliferating;Publishing;Quantitative Reverse Transcriptase PCR;RANTES;Reporter;Research;Research Personnel;Ribosomal RNA;Role;Seminal;SERPINE1 gene;Serum;Shotgun Sequencing;skills;Source;Specimen;stool sample;System;Techniques;Thinness;tool;trafficking;Training;transcriptomics;Triglycerides;Universities;Washington;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Microbial drivers of metabolically unhealthy obese phenotype

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Lung;Precision Medicine;Prevention;Pulmonary Hypertension

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Portopulmonary hypertension (PoPH) patients suffer from a cardiovascular disease with very high morbidity and mortality that occurs exclusively in those with underlying liver disease. Although both the incidence and prevalence of chronic liver disease and PoPH have been increasing, the mechanisms by which liver dysfunction leads to PoPH, the optimal markers of disease, and the best treatments to improve outcomes in this high-risk population, are all poorly developed. This work, focusing on dysregulated vascular endothelial growth factor signaling and hepatocellular dysfunction, addresses this urgent and growing clinical need by identifying and developing new biomarkers that will enable more accurate diagnosis, improved risk stratification, and more precise treatment for patients with PoPH, ultimately leading to improved clinical outcomes in this high-risk population.

PI_NAMEs: JOSE, ARUN  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: accurate diagnosis;Address;Affect;aggressive therapy;angiogenesis;Animal Model;Arterial Disorder;Benchmarking;biobank;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker validation;Blood Vessels;Bone Morphogenetic Proteins;Brain natriuretic peptide;candidate identification;candidate marker;Cardiac Catheterization Procedures;Cardiovascular Diseases;career development;chronic liver disease;Cirrhosis;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;clinically significant;cohort;Collaborations;Data;Data Analyses;data repository;Dedications;Deterioration;Development;Development Plans;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic value;differential expression;Disease;Disease Marker;disease phenotype;Early Diagnosis;Early treatment;Endothelial Cells;Ensure;Environment;Epidemiology;Estrogen Metabolism;Estrogens;Exhibits;experience;FLT1 gene;Foundations;Functional disorder;Future;Gene Expression;Genes;Goals;Hepatic;Hepatic Stellate Cell;high risk population;hypertensive;improved;improved outcome;Incidence;Institution;interdisciplinary approach;Knowledge;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;liver transplantation;Longitudinal cohort;Lung;Lung Diseases;Measures;Mentors;Modeling;Molecular;Morbidity - disease rate;mortality;Natriuretic Peptides;next generation sequencing;novel;novel diagnostics;novel marker;Nuclear RNA;Outcome;participant enrollment;Pathogenesis;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Peptides;Population;Portal Hypertension;portopulmonary hypertension;predictive marker;pressure;Prevalence;PRKCA gene;Prognosis;Prognostic Marker;prognostic performance;prognostic value;prognostication;prospective;Protein Secretion;Proteins;Public Health;pulmonary arterial hypertension;pulmonary arterial pressure;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary Vascular Resistance;receptor;Regulation;Research;Research Project Grants;Resources;response;risk stratification;Sampling;Serum;Severity of illness;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;specific biomarkers;Specificity;stellate cell;success;targeted treatment;Testing;Therapeutic;therapeutic target;Tissue Banks;Tissue-Specific Gene Expression;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Translational Research;treatment response;United States National Institutes of Health;Validation;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vascular remodeling;Work

PROJECT_TITLE: Biomarker Discovery in Portopulmonary Hypertension

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RELEVANCE Lipid trafficking pathways play central roles in cell physiology and in responses to challenges by microorganisms. Some intracellular pathogens including Toxoplasma gondii, an opportunistic pathogen in HIV/AIDS patients, subvert these pathways during infection. Our goal is to study the molecular mechanisms employed by Toxoplasma to hijack the vesicular and nonvesicular trafficking in mammalian cells for lipid scavenging and survival.

PI_NAMEs: COPPENS, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Abbreviations;Address;Affect;Binding;Biochemical;Biochemical Pathway;Biological Assay;Cell membrane;Cell Physiology;Cells;Cellular biology;chemotherapy;Cholesterol;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytoplasm;Cytoplasmic Granules;design;Development;differential expression;Docking;Encephalitis;Endosomes;Filament;Future;Genes;genetic manipulation;Genetic Screening;Genetic Techniques;Genome;Goals;Golgi Apparatus;HIV/AIDS;Immunocompromised Host;Immunofluorescence Immunologic;Individual;Infection;insight;Intercept;Intervention;lipid transfer protein;lipid transport;Lipids;Mammalian Cell;Mediating;Membrane;Membrane Proteins;microorganism;Microscopic;model organism;Modeling;Molecular;mutant;Nature;novel;Nutrient;obligate intracellular parasite;opportunistic pathogen;Organelles;Parasites;pathogen;Pathway interactions;Patients;Penetration;Phosphatidylcholine-Sterol O-Acyltransferase;Phospholipase;Plasma Cells;Play;Process;protein complex;Protein Secretion;Proteins;Proteome;rab GTP-Binding Proteins;recruit;Recycling;Resources;response;Role;Route;Site;Sorting;Sphingolipids;System;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;trafficking;Transmembrane Transport;Vacuole;Vesicle;vesicle-associated membrane protein;Work

PROJECT_TITLE: Mechanisms and functions of host organelle usurpation by intravacuolar Toxoplasma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(02)M]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative We will determine the molecular mechanisms regulating alveolar macrophage selfrenewal and inflammatory activity, and the downstream effects on pulmonary inflammation and tissue recovery during influenza virus infection. Furthermore, we will investigate whether targeting b-catenin and/or HIF1-a pathways will reverse aging-associated impairment in alveolar macrophage selfrenewal and function, thereby dampening severe disease development during influenza virus infection in aged hosts.

PI_NAMEs: SUN, JIE  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: aged;Aging;aging population;aging related;aging reversal;Alveolar Macrophages;anti-influenza;antiviral immunity;beta catenin;Binding;cancer cell;Cessation of life;Complex;Defect;Development;Disease;Elderly;Exhibits;Functional disorder;Future;Genes;Genetic;global health;Glycolysis;HIF1A gene;Homeostasis;Immune response;Impairment;in vitro activity;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Influenza A virus;influenza infection;Ligands;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung injury;lung repair;Macrophage;Mediating;Metabolic;Metabolic Pathway;Mitochondria;Molecular;monocyte;Myeloid Cells;Names;Natural Immunity;Natural regeneration;novel;Parabiosis;Pathway interactions;pharmacologic;Population;Preventive;Production;Proliferating;protein complex;Pulmonary Inflammation;Recovery;Repression;response;Role;self-renewal;Signal Transduction;stem;stem cell proliferation;TCF7L2 gene;Techniques;Therapeutic;tissue repair;Tissues;Upper Respiratory Infections;Virus Diseases

PROJECT_TITLE: Elucidating the roles of alveolar macrophage inflammation and self renewal duringinfluenza infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: CHEMISTRY

PHR: Project Narrative (Public Health Relevance Statement) The efficient development of new medicines for disease treatment and prevention plays a vital role in improving the quality of human life. The work described herein focuses on the invention of novel copper-catalyzed chemical reactions for the construction of carbon- carbon and carbon-heteroatom bonds. In doing so, this research will provide new tools for the efficient synthesis of biologically relevant molecules from simple starting materials using earth-abundant catalysts.

PI_NAMEs: LIU, WEI  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Agrochemicals;Alcohols;Alkylation;Carbon;Catalysis;catalyst;Characteristics;chemical reaction;Complex;Copper;Coupling;Development;Disease;Elements;Generations;Goals;Human;Hydrogen Bonding;improved;invention;Life;Medicine;Metals;Natural Products;novel;Organic Chemistry;Pathway interactions;Pharmacologic Substance;Planet Earth;Play;Prevention;public health relevance;Reaction;Research;Role;small molecule;tool;Transition Elements;Work

PROJECT_TITLE: New Strategies for Copper-Catalyzed Cross-Coupling of Alkyl Electrophiles


NIH_SPENDING_CATS: Genetics

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative (3 sentences, lay) Our present knowledge of mitochondria highlights activities beyond energy production and into their decision- making role in a multitude of cellular processes. While our insight on the essential roles of mitochondrial signaling in disease-relevant processes such as innate immunity is rapidly expanding, several questions remain regarding the origin, mechanisms, and significance of such phenomena. With powerful genetic approaches and cutting- edge technologies, we aim to clarify the relationship between mitochondria and innate immunity, with the potential for paving new therapeutic approaches for human diseases with inflammatory components.

PI_NAMEs: TIGANO, MARCO  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Aerobic Bacteria;Antitumor Response;Autoimmune Diseases;Autoimmunity;Bacteria;Biology;Calcium Signaling;cancer therapy;Cell Aging;Cell Death;Cell Nucleus;Cell Physiology;Cellular Immunity;Cellular Stress;Collaborations;Cytosol;Dangerousness;Decision Making;Disease;Eukaryotic Cell;Evolution;experience;Generations;genetic approach;Genetic Materials;Genetic Transcription;Genome;Goals;Health;Homo sapiens;Human;human disease;Immunity;In Vitro;in vivo;Inflammatory;insight;Knowledge;knowledge translation;Mediating;member;Mitochondria;Mitochondrial DNA;Mitochondrial RNA;Natural Immunity;neuroinflammation;novel therapeutic intervention;Nucleic Acids;Organelles;Oxidative Phosphorylation;Pathway interactions;Permeability;Process;Production;programs;Proteins;Research;Research Personnel;RNA;Role;sensor;Signal Transduction;Source;Stress;stressor;Technology;Translating;Translations;Virus;Work

PROJECT_TITLE: From mtDNA stress to cellular immunity: Triggers, Mechanisms and Effectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infant Mortality;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sepsis;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Sepsis and necrotizing enterocolitis (NEC) cause serious morbidity and mortality for premature infants in the Neonatal Intensive Care Unit, and early detection and treatment improves outcomes. We have made important discoveries toward developing early warning systems for sepsis and NEC using advanced vital sign analytics in a multi-center collaboration and are expanding analyses, collaborating sites, and methods to develop generalizable predictive monitoring algorithms. In doing so, we also aim to build an open access data and analytics platform that will ensure rigor and reproducibility of the work and spur new discoveries to further improve outcomes of preterm infants.

PI_NAMEs: FAIRCHILD, KAREN D (contact);SULLIVAN, BRYNNE ARCHER

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;advanced analytics;Adverse event;adverse outcome;Alabama;algorithmic bias;Algorithms;analytical tool;Apnea;Breathing;Caring;Censuses;Characteristics;Clinical;clinical care;Clinical Data;Collaborations;comparative;Complex;Data;data access;Data Analytics;Data Commons;Data Science;Data Set;data sharing;data tools;Demographic Impact;demographics;deprivation;Deterioration;Development;Early Diagnosis;Early treatment;Electrocardiogram;Ensure;Environment;Ethnic Origin;experience;Goals;Grant;Health;Heart Abnormalities;Heart Rate;Hour;improved;improved outcome;individual patient;Infant;Inflammatory;Informatics;innovation;Institution;Instruction;interest;Life;Machine Learning;Measures;Metadata;Methods;Monitor;Morbidity - disease rate;mortality;Necrotizing Enterocolitis;Neonatal Intensive Care Units;novel;operation;Outcome;Patient Care;Patients;Pattern;Performance;Physiologic Monitoring;Physiologic pulse;Physiological;Population;prediction algorithm;premature;Premature Infant;Premature Mortality;Process;profiles in patients;Pulse Oximetry;Pulse Rates;Race;randomized trial;randomized, clinical trials;Reporting;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Reduction;Schools;Seminal;Sepsis;Series;sex;Signal Transduction;Site;Socioeconomic Status;socioeconomics;System;Technology;terabyte;Testing;Time;Time Series Analysis;trend;United States National Institutes of Health;Universities;Variant;Very Low Birth Weight Infant;Virginia;Washington;Work

PROJECT_TITLE: Predictive informatics monitoring in the Neonatal Intensive Care Unit

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Malaria remains a major public health problem in Kenya, where progress towards malaria elimination has stagnated and the threat of disease resurgence persists. Enhanced epidemiological surveillance systems are needed to identify foci of transmission for targeted malaria control and to evaluate the effectiveness of malaria control programs. In settings of rapidly declining transmission, where asymptomatic infections predominate and silently sustain transmission, high-resolution spatial and epidemiological data are particularly needed to inform the development of optimal malaria control strategies aimed at eliminating transmission reservoirs.

PI_NAMEs: JEANG, BROOK  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Area;Bioinformatics;Blood;burden of illness;career;Cessation of life;Clinical;Communicable Diseases;Communities;Country;County;Data;deep sequencing;design;Detection;detection method;Development;Diagnosis;Diagnostic Procedure;Disease;Disease Outbreaks;Dryness;effective therapy;effectiveness evaluation;Effectiveness of Interventions;epidemiologic data;Epidemiologic Monitoring;Epidemiologist;Epidemiology;Exhibits;experience;Faculty;Genetic;genetic epidemiology;genetic variant;Genotype;Geography;global health;Goals;Health care facility;Hospitals;Household;improved;Incidence;indexing;Infection;Infectious Disease Epidemiology;Infrastructure;international center;Intervention;Kenya;Leadership;Malaria;Malaria Diagnostic;malaria infection;malaria transmission;Maps;Measures;member;Mentorship;Microsatellite Repeats;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;multidisciplinary;Nosocomial Infections;novel strategies;Outcome;Parasites;Pattern;Plasmodium;Population Genetics;Prevalence;Program Reviews;programs;Public Health;Reporting;Research;Research Personnel;Residual state;Resolution;Risk;Sampling;scale up;screening;skills;Spatial Distribution;spatial epidemiology;Spottings;stem;Stratification;Surveillance Methods;System;Testing;tool;Training;transmission process;vector

PROJECT_TITLE: Epidemiology and Population Genetics of Malaria Parasites in Kenya

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Byron Lai, PhD – R21  Project Narrative This home-based, telehealth trial will pilot the preliminary efficacy of a scalable sprint interval training program with enjoyable themes and music to improve cardiovascular fitness and cardiometabolic health among children with cerebral palsy. This project has the potential to address a large knowledge gap in the extant literature, because there are no widely accessible, evidence-based, enjoyable, and age-appropriate modalities for improving cardiovascular fitness or cardiometabolic health among children with disabilities who have mobility disabilities. The study findings will inform a larger, definitive efficacy study that can be easily implemented by researchers and health professionals across a variety of settings.

PI_NAMEs: LAI, BYRON  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;Adverse event;Aerobic;Aerobic Exercise;Age;aged;arm;Behavior;Behavioral;Blood;Blood Pressure;Body Composition;Body measure procedure;Body Weight;C-reactive protein;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular fitness;Cerebral Palsy;Child;Child Welfare;Cholesterol;cloud based;cohort;Community Networks;community organizations;Control Groups;coronavirus pandemic;design;Development;disability;Disabled Children;Doctor of Philosophy;Dryness;Dual-Energy X-Ray Absorptiometry;effectiveness trial;efficacy study;efficacy/implementation trial;empowerment;Enrollment;Ensure;Equipment;evidence base;Exercise;Exercise Physiology;exercise program;Exercise Test;experience;Fatty acid glycerol esters;Fingers;fitness intervention;follow-up;Functional impairment;General Population;Glycosylated hemoglobin A;Health;Health Benefit;Health Professional;high risk;Home;improved;innovation;Insulin;Internet;Interval training;Intervention;Knowledge;Leg;life span;Literature;Measures;Metabolic;Metabolic syndrome;Methods;Mobility decline;Mobility disability;Modality;Modeling;Modification;Monitor;mortality;mortality risk;Movement;Music;novel;Outcome;Oxygen Consumption;Participant;participant safety;Pediatric Hospitals;Persons;Physical activity;Physical Education;physical inactivity;physically handicapped;Pilot Projects;portability;post intervention;pressure;prevent;Procedures;Process;Program Appropriateness;programs;Random Allocation;Randomized;Randomized, Controlled Trials;Recovery;recruit;Research;Research Personnel;Rest;Roentgen Rays;Running;Safety;Sample Size;scale up;Schools;Site;Sphygmomanometers;Spirometry;Sports;Spottings;Supervision;Techniques;telehealth;telemonitoring;Testing;Thinness;Time;Tissues;Training Programs;Translating;Transportation;Triglycerides;Underserved Population;Video Recording;Visual;Waiting Lists;Walking;Wheelchair user;Work

PROJECT_TITLE: Improving Cardiorespiratory Fitness and Cardiometabolic Health among Children with Physical Disabilities through Movement-to-Music Telehealth with Arm-based Sprint-Intensity Interval Training

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative Although true in all disciplines, the role of a collaborative biostatistician is particularly important in addiction research given the types of problems commonly addressed, such as the use of complex study designs, large amounts of informed missing data and study dropout, along with the need to quantify complex mechanisms of action or underlying relationships. The Collaborative Undergraduate Biostatistics Experience (CUBE) program provides a unique opportunity for underrepresented minority students in STEM from around the country to work together in a vibrant academic collaborative environment with active researchers from a variety of disciplines related to addiction. Guided by Lent, Brown, and Hackett’s (1994) Social Cognitive Career Theory (SCCT) conceptual framework, the CUBE program is built on the following four pillars: 1) training in introductory biostatistics; 2) training in R programming; 3) professional development (PD); and 4) a collaborative research project addressing research questions in the area of addiction.

PI_NAMEs: HANLON, ALEXANDRA L (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Address;African American;Alaska Native;Alcohol dependence;American;American Indians;Area;Awareness;Behavior;behavioral economics;Biological;Biomedical Research;Biometry;Black American;Black race;career;career networking;Clinical Research;Cognitive;Collaborations;collaborative environment;Communication;Communication difficulty;Complex;Country;Data;Data Science;Decision Making;design;Development;Discipline;Doctor of Philosophy;Dropout;Drug Addiction;Education;Employment;Environment;Ethnic Population;evidence base;experience;faculty mentor;faculty support;food addiction;Foundational Skills;Foundations;Future;Graduate Degree;graduate school;graduate student;Health;health data;Health Sciences;Health Technology;Hispanic;Human;Indigenous;Infrastructure;interest;Investments;Knowledge;Latino;Latinx;Learning;Master of Science;mathematical methods;Mediation;Medical;men;Mental disorders;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Native Hawaiian or Other Pacific Islander;Neurosciences;novel;Participant;peer;peer support;Persons;Preparation;Principal Investigator;programs;recruit;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Role;Schools;Science;Series;skills;social;Social Behavior;Statistical Methods;statistics;STEM field;Structure;student mentoring;student participation;student retention;Students;summer program;summer research;symposium;theories;tool;Training;training opportunity;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States;United States National Institutes of Health;Virginia;Woman;Work

PROJECT_TITLE: CUBE: A Collaborative Undergraduate Biostatistics Experience to Diversify and Bring Awareness to the Field of Collaborative Biostatistics

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because of the positive impact that the discovery of mechanisms underlying synaptic integrity in resilient individuals will reveal novel therapeutic concept centered on inducing resilience and extend this novel concept to related disorders that share with AD the pathological disruption of synapses. The proposed research is aligned to NIH’s mission of fostering creative discoveries to protect and improve health.

PI_NAMEs: FRACASSI, ANNA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affect;aged;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;ANXA5 gene;Autopsy;Axon;axon injury;Binding;Biological Assay;Brain;Cd68;Cell Nucleus;Cell surface;Clinical;Cognitive;Cognitive deficits;Creativeness;Data;demented;Dementia;Development;Disease;DLG4 gene;Eating;Event;Excision;expectation;Flow Cytometry;Fostering;frontal lobe;Functional disorder;Future;Genes;Genetic study;Goals;Health;Hippocampus;Histopathology;Human;Hyperactivity;Impaired cognition;improved;Individual;injured;innovation;insight;Lead;Ligands;Ligation;loss of function;Lysosomes;Maintenance;Mediating;Mediator;Memory impairment;Microglia;Mission;Molecular;Morphology;Mutation;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;non-demented;novel;novel therapeutics;Pathologic;Pathway interactions;Persons;Phagocytes;Phagocytosis;Phenotype;Phosphatidylserines;Population;postsynaptic;Process;Public Health;receptor;Research;resilience;Risk;Role;Sampling;Senile Plaques;Signal Transduction;Stains;Structure;superresolution microscopy;Synapses;synaptic function;Synaptosomes;Testing;therapeutically effective;transcriptome;transcriptome sequencing;TREM2 gene;TYROBP gene;United States National Institutes of Health;Variant;Western Blotting

PROJECT_TITLE: Role of microglia in cognitive resilience to AD

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Neurosciences;Prevention;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Narrative The use of aromatase inhibitors (AI) such as letrozole for breast cancer therapy is associated with severe joint and muscle symptoms, which compromises adherence and persistence with AI therapy. Currently, no clearly effective therapies exist for prevention or treatment of AI-associated musculoskeletal symptoms. This proposal focuses on preclinical validation of sphingosine-1-phosphate receptor 1 (S1P1) modulators as a potential strategy to alleviate AI-associated musculoskeletal symptoms.

PI_NAMEs: DAMAJ, M. IMAD  (contact);SELLEY, DANA E;SIM-SELLEY, LAURA J

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acute;Adherence;adjuvant endocrine therapy;Adjuvant Therapy;Affinity;Agonist;antagonist;Aromatase;Aromatase Inhibitors;Arthralgia;Astrocytes;Behavior;Breast Cancer cell line;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;cancer type;Cell Lineage;cell type;Chronic;comparison control;conditional knockout;cytokine;Data;desensitization;design;Development;Diagnosis;Disease-Free Survival;Dose;Down-Regulation;effective therapy;Effectiveness;efficacious treatment;Ensure;Estrogen receptor positive;Fatigue;FDA approved;Female;Functional impairment;G-Protein-Coupled Receptors;Genetic;genetic approach;GTP-Binding Proteins;hormone receptor-positive;In Vitro;in vivo;Inflammatory;inhibitor therapy;Joints;Knockout Mice;Letrozole;Ligands;Lumbar spinal cord structure;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;Microglia;Modeling;mortality;mouse model;multiple sclerosis treatment;Mus;Muscle;muscle stiffness;Musculoskeletal;Myalgia;Neurons;new therapeutic target;novel;novel therapeutics;Oral;Oral Administration;Ovariectomy;overexpression;Pain;Patients;Pharmaceutical Preparations;pharmacologic;Play;Postmenopause;pre-clinical;prevent;Prevention;Prevention strategy;Prodrugs;protein activation;receptor;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Recurrence;Role;side effect;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Spinal;Symptoms;Syndrome;System;Testing;therapy development;Time;Toxic effect;tumor;United States;Validation;Woman

PROJECT_TITLE: Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;Human Genome;Opioid Misuse and Addiction;Opioids;Pediatric;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Gene identification for many substance use disorders continues to be hampered by small sample sizes. We propose to apply new multivariate genomic techniques to increase the power to identify genes involved in substance use disorders, and to characterize the risk associated with identified variants in diverse longitudinal samples in order to understand how genetic risk unfolds across development, and in conjunction with the environment. Each of these areas represents critical steps in using genetic data to improve prevention, intervention, and treatment for substance use disorders, and will lay the foundation as we move into an era of personalized medicine.

PI_NAMEs: DICK, DANIELLE M (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: addiction;Adolescence;Affect;Age;alcohol use disorder;Alcohols;Area;Behavioral;behavioral phenotyping;biobank;Bioinformatics;Biological;clinical diagnosis;Complex;Consumption;Data;Data Set;Detection;Development;emerging adulthood;Environment;Environmental Risk Factor;Ethnic Origin;Foundations;gene discovery;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic Techniques;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Goals;Health;high risk;Human;improved;Individual;insight;Intervention;longitudinal dataset;Maps;marijuana use disorder;Mediating;Mental disorders;Meta-Analysis;Methods;Multivariate Analysis;National Longitudinal Survey of Adolescent to Adult Health;novel;Opiate Addiction;opioid use disorder;Outcome;Pathway interactions;personalized medicine;Phenotype;polygenic risk score;population based;Prevention;Process;Psychiatry;Race;Risk;Running;Sample Size;Sampling;sex;Signal Transduction;Structure;substance use;Substance Use Disorder;substance use treatment;Techniques;Testing;trait;Translating;Twin Multiple Birth;Variant

PROJECT_TITLE: Using the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of Risk

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE While previous studies have shown that ATF4 functions as a transcriptional regulator in diverse cell types and tissues under various physiological and pathological conditions, including cardiac diseases, little is known as to the specific role of ATF4 in cardiomyocytes. Our proposed studies will help us to understand the biological function of ATF4 in cardiomyocytes at molecular, cellular, and physiological levels, specifically the mechanism by which ATF4 regulates cardiomyocyte proliferation and function in a p53-dependent and -independent manner, as well as to determine a safe therapeutic window for the potential application of ATF4 and/or p53 inhibitors in cardiac diseases.

PI_NAMEs: CHEN, JU  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Ablation;activating transcription factor;activating transcription factor 4;Address;Adult;Appearance;Atrial Fibrillation;Binding;Binding Sites;biological adaptation to stress;Biological Process;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;cell type;Cellular Stress;Cessation of life;chromatin immunoprecipitation;Complex;congenital heart abnormality;Cyclic AMP-Responsive DNA-Binding Protein;Data;Defect;Development;Dilated Cardiomyopathy;Dimensions;Disease;DNA;Down-Regulation;Embryo;Exhibits;Family;Family member;Genes;Genetic Transcription;genome-wide;Heart;heart defect;Heart Diseases;Heart failure;heart function;in vivo;inhibitor;Knock-out;Knockout Mice;Knowledge;Left;Leucine Zippers;Maintenance;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Modeling;Molecular;Morphogenesis;Morphology;mouse model;Mus;myosin light chain 2;Neonatal;new therapeutic target;novel;Pathologic;Pathway interactions;Patients;Perinatal mortality demographics;pharmacologic;Pharmacologic Substance;Phenotype;Physiological;Physiology;Play;postnatal;programs;Proliferating;Protein Family;Proteins;Regulation;Regulator Genes;Reporting;Role;Series;side effect;Tamoxifen;Therapeutic;Thick;Thinness;Tissues;TP53 gene;transcription factor;transcriptome sequencing;Transgenic Mice;Troponin T;Up-Regulation;Ventricular;Xenopus laevis

PROJECT_TITLE: ATF4 a Novel Regulator of Cardiac Development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Mammalian retinal ganglion cells (RGCs), the neurons that convey information from the eye to the brain, cannot regenerate their axons once the optic nerve is injured, resulting in permanent vision loss. Some degree of optic nerve regeneration has been achieved in the past, but the extent of regeneration remains far from a level needed for significant visual recovery, pointing to the need for more effective therapies. Based on our recent transcriptome-based analysis of receptors for trophic factors, chemokines, and peptides that are expressed in adult RGCs, I will carry out a systematic bio-activity screening in vitro and in vivo to identify novel growth- and survival factors, followed by a complementary study to identify the responsive RGC subtypes, with the goal of discovering novel growth- and pro-survival factors to enable multiple RGC subtypes to survive injury and extend lengthy axons, potentially augmenting optic nerve regeneration well beyond currently achievable levels.

PI_NAMEs: YIN, YUQIN  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Adult;antagonist;Apoptotic;Axon;axon growth;axon regeneration;Blindness;Brain;Cell Culture System;Cell Death;Cell Survival;Cells;chemokine;chemokine receptor;combinatorial;Combined Modality Therapy;Cytoprotection;Data;Data Set;Dose;effective therapy;experience;Eye;Genetic study;Goals;Growth;Growth Factor;Image;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Inflammation;Inflammatory;injured;Injury;Label;Ligands;Mammals;Mediating;Mediator;Methods;Modeling;Mus;Natural regeneration;Nerve Crush;nerve damage;Neurons;neuroprotection;new growth;novel;Optic Nerve;Optic Nerve Injuries;optic nerve regeneration;Peptide Receptor;Peptides;receptor;Recovery;Recovery of Function;regeneration model;regenerative;regenerative cell;resilience;response;retinal ganglion cell regeneration;Retinal Ganglion Cells;screening;Systems Analysis;Testing;Time;Toxic effect;transcriptome;transcriptome sequencing;Trophic Factor Receptor;Vision;Visual;visual information;Work

PROJECT_TITLE: Novel growth factors and regenerative RGC subtypes for optic nerve regeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Dementia diagnosis, prevention and treatment has entered an exciting new era where a patient can be diagnosed with a simple blood test and new drugs promise to target the abnormal proteins that accumulate in the brain and cause the slow death of neurons, memory and thinking. While this is an occasion for celebration, almost nothing is known regarding the burden of dementing illness, what types of dementia are most prevalent, or how well new dementia blood tests work in Native American individuals. The current study seeks to answer these questions so that all Americans can benefit from the 21st century advances in dementia care.

PI_NAMEs: MANTYH, WILLIAM G (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: African ancestry;Age;Alleles;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;American;American Indians;Amyloid;Attenuated;behavioral neurology;Benefits and Risks;biobank;Biology;Blood Tests;blood-based biomarker;Brain;brain health;Centers for Disease Control and Prevention (U.S.);cerebral atrophy;Chippewa;cigarette smoking;Climacteric;Clinic;Cognitive;Country;Craniocerebral Trauma;Data;demented;Dementia;dementia burden;dementia care;dementia risk;Dementia with Lewy Bodies;design;Development;Diagnosis;Diagnostic;Eligibility Determination;Enrollment;epidemiologic data;Epidemiology;European ancestry;Evaluation;Foundations;Funding;Genes;genetic risk factor;Goals;Health Campaign;health disparity;Health Policy;Heart Diseases;high risk population;Homozygote;Impaired cognition;improved;Incidence;Individual;informant;Inherited;Institutional Review Boards;Japanese Population;Knowledge;Laboratories;Link;Magnetic Resonance Imaging;Measures;Medical;Memory;Minnesota;Native American Ancestry;Native American community;Native American population;Native Americans;neuroimaging;neuron loss;Neuropsychological Tests;Nigerian;novel therapeutics;Participant;Patient Self-Report;Patients;personalized medicine;Phosphorylation;Plasma;Play;Population;Prevalence;prevent;Prevention;Prevention strategy;Probability;prospective;Proteins;Public Health;racial population;Reporting;Research;research clinical testing;Risk;Role;Sampling;Surveys;tau Proteins;tau-1;Telephone;Test Result;Testing;Thinking;Threonine;Time;Translating;treatment strategy;tribal health;Tribes;United States;Universities;Vascular Dementia;virtual;Visit;Work;Writing

PROJECT_TITLE: Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Glucose variability which reflects fluctuations into hypo- and hyperglycemic ranges have been linked to diabetes complications, but little is known about factors that affect glucose variability in type 2 diabetes. This study will examine personal factors and social-built environmental factors associated with glucose variability among multi-ethnic adults with type 2 diabetes in real-time, natural living environment. The findings from the proposed study will facilitate effective treatment by identifying risk factors of glucose variability and inform the future development of personalized just-in-time interventions targeting lifestyle behaviors with an increased understanding of glucose variability by providing support for healthcare providers’ clinical decisions and patients’ diabetes self-management.

PI_NAMEs: NAM, SOOHYUN  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: actigraphy;Address;adherence rate;Adult;Affect;Affective;Age;Alcohol consumption;Behavior;Blinded;Blood Glucose;blood glucose regulation;Body mass index;built environment;Cardiovascular Diseases;Characteristics;Clinical;clinical application;clinical decision-making;clinical practice;comorbidity;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Data Collection;Death Rate;demographics;Development;diabetes distress;Diabetes Mellitus;diabetes self-management;Diet;dietary;Eating;Ecological momentary assessment;effective therapy;Environment;Environmental Risk Factor;epidemiology study;ethnic minority;Ethnic Origin;Ethnic Population;Exercise;experience;Fasting;food insecurity;Frequencies;Future;Glucose;glucose metabolism;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health Personnel;High Prevalence;high risk;Hour;Hyperglycemia;hypothalamic-pituitary-adrenal axis;improved;Income;Individual;insight;Insulin-Dependent Diabetes Mellitus;Intake;Intervention;Knowledge;Life Style;lifestyle data;lifestyle factors;Link;macrovascular disease;Measures;Mediating;middle age;moderate-to-vigorous physical activity;mortality;multi-ethnic;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;older adult;Outcome;Participant;Patients;personalized intervention;Persons;Pharmaceutical Preparations;Physical activity;Pilot Projects;prospective;Protocols documentation;Provider;Public Health;Publishing;Quality of life;Questionnaires;Race;racial discrimination;racial diversity;racial minority;randomized trial;Research;response;Risk;Risk Factors;risk prediction;Role;sedentary;sex;Sleep;sleep quality;Smoking;social;social cohesion;Social support;Stress;Teenagers;Time;time interval;Well in self

PROJECT_TITLE: Personal and social-built environmental factors of glucose variability among multi ethnic groups of adults with type 2 diabetes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Dietary Supplements;Genetics;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) Alzheimer’s disease (AD) features oxidative stress and transcriptional dysregulation that leads to impairments in hippocampal-dependent learning. We hypothesize that reduced bioavailability of the antioxidant all-trans retinoic acid (ATRA), combined with epigenetic changes in the hippocampal dentate gyrus, accelerate AD onset. Using a novel approach that integrates behavioral, transcriptomic, and metabolomic/lipidomic data, this proposal tests the hypothesis that the synergistic combination of ATRA supplementation and an FDA-approved histone deacetylase inhibitor maintains hippocampal-dependent learning and ATRA-sensitive gene transcription more effectively than either monotherapy alone.

PI_NAMEs: LAWRENCE, JOHN JOSHUA (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease brain;Antioxidants;Autopsy;behavior test;Behavioral;Binding;Biological Assay;Biological Availability;cell type;Clinical Trials;Complex;Data;dentate gyrus;dietary antioxidant;Disease Progression;DNA;drug repurposing;Epigenetic Process;FDA approved;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genetic Transcription;Hippocampus;Histone Deacetylase;Histone Deacetylase Inhibitor;Hormones;Impairment;innovation;interdisciplinary approach;Knowledge;Learning;life span;Ligand Binding;Ligands;lipidomics;Lipids;Mediating;Memory;metabolomics;Methods;mouse model;Multiomic Data;multiple omics;novel strategies;Onset of illness;Outcome Measure;oxidative damage;Oxidative Stress;predictive signature;Predictive Value;prevent;Process;Proteins;public health relevance;Reactive Oxygen Species;Retinoic Acid Receptor;Retinoic Acid Response Element;Rodent;Role;secondary analysis;Signal Transduction;Supplementation;tau Proteins;Testing;Time;Transcriptional Regulation;transcriptomics;translational potential;Tretinoin;Up-Regulation;Vitamin A

PROJECT_TITLE: The hippocampal dentate gyrus in aging and Alzheimer's disease: boosting transcription of retinoic acid-sensitive genes through vitamin A supplementation and HDAC inhibition


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Narrative: The proposed research is relevant to public health because the novel methods will allow us to comprehensively analyze surface protein interactions. Considering the importance of surface proteins, the innovative method will be extensively applied to biomedical research for advancing our understanding of protein functions and the molecular mechanisms of human disease, which will lead to the discovery of surface proteins as effective biomarkers for disease detection and novel drug targets for disease treatment. Thus, the proposed research is relevant to the portion of NIH’s mission that pertains to seeking fundamental knowledge that will enhance health, lengthen life, and reduce disability.

PI_NAMEs: WU, RONGHU  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Apoptosis;Binding Proteins;Biological Markers;Biological Process;Biology;Biomedical Research;Cell Communication;Cell Mobility;Cell Polarity;Cell surface;Cell Surface Proteins;Cell-Cell Adhesion;Cells;Cellular Morphology;Chemicals;Chemistry;crosslink;Crosslinker;Data;Detection;Detergents;Development;disability;Disease;Drug Targeting;Effectiveness;Embryonic Development;Enzymes;Epithelial Cells;epithelial to mesenchymal transition;Event;extracellular;Health;human disease;innovation;insight;Investigation;Knowledge;Life;Malignant Neoplasms;Mammalian Cell;Membrane Glycoproteins;Membrane Proteins;Mesenchymal;Methods;Mission;Modification;Molecular;new therapeutic target;novel;Nutrient;oxidation;Peptides;Play;Polysaccharides;Preparation;Process;Property;Protein Analysis;protein function;Proteins;Proteomics;Public Health;Reaction;receptor;Regulation;Research;Resistance;Role;Sampling;Signal Transduction;Surface;Transportation;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: Effective MS-Based Methods for Unraveling Cell Surface Protein Interactions

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Children in underserved communities across the western United States are disproportionately exposed to and affected by air pollution including wildfire smoke. There is a need to identify local resources and implement interventions to improve air quality in order to lessen the health burden on youth. Through Youth Participatory Action Research (YPAR), this project will engage high school students to work within their school communities to increase local air quality knowledge, to implement interventions in their schools to reduce air pollution, and train them to be more informed and proactive citizens.

PI_NAMEs: D'EVELYN, SAVANNAH M (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Administrator;Advocate;Affect;Air;Air Pollution;Attitude;Award;Awareness;Back;Behavior;behavior change;behavioral outcome;Breathing;career;Child;Child Health;Climate;Communities;Community Actions;community based participatory research;Community Health;community setting;Decision Making;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;empowerment;Environment;environmental change;Environmental Health;Environmental Impact;Evaluation;experience;Exposure to;Family;Fostering;Future;Goals;Health;health equity;health equity promotion;Health Promotion;high school;High School Student;implementation evaluation;implementation intervention;implementation science;improved;Intervention;Interview;Knowledge;Learning;Link;Location;Lung;Maps;Measurement;Measures;member;Mentors;Mentorship;Methodology;Monitor;Movement;Organ;Outcome;Parents;Phase;Policies;pollutant;Populations at Risk;Prevention;Process;programs;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Research Project Grants;Resources;respiratory health;school environment;School-Age Population;Schools;Science;Seasons;Self Efficacy;skills;Smoke;Structure;student participation;Students;Surveys;teacher;Testing;Time;Toxicology;Training;Translating;underserved community;United States;Wildfire;Work;Youth

PROJECT_TITLE: Learning and Living with Wildfire Smoke: Creating Clean Air Environments in Schools through Youth Participatory Action Research


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative A better understanding of modifiable factors that can prevent dementia onset, like educational attainment, is critical given that existing biomedical interventions have failed to reverse or slow the course of disease. We propose to build an interdisciplinary network of scientists whose joint expertise is vital to achieving NIA’s goal to reduce educational disparities in Alzheimer’s Disease and Related Dementias (ADRD): population health scientists, with their robust expertise in the social and behavioral factors, including educational attainment, that shape dementia risk and resilience, and ADRD researchers, with their robust expertise in the biology and neurocognitive aspects of ADRD.

PI_NAMEs: ASTHANA, SANJAY ;HERD, PAMELA ;WALSEMANN, KATRINA  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: aged;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Attention;Award;Behavior;Behavioral;Biological;Biology;Biosocial;Black race;Brain Pathology;Clinical;Clinical Treatment;Collaborations;college;Communication;Communities;Complex;Data;data resource;Dementia;dementia risk;Development;Discipline;Disease;Disparity;Education;Educational workshop;ethnic difference;ethnic health disparity;Ethnic Origin;Funding;Genetic;Goals;Grant;Grant Review;Health behavior;health disparity populations;High Prevalence;high school degree;Inflammatory;Intervention;Joints;Leadership;Life;Link;Longitudinal Studies;Measures;meetings;member;Methods;middle age;Neurocognitive;older adult;Pathway interactions;Pattern;Pilot Projects;Policies;population health;Population Heterogeneity;Population Study;prevent;psychologic;racial difference;racial health disparity;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;resilience;Risk;Role;Scholarship;Science;Scientific Advances and Accomplishments;Scientist;Shapes;social;social media;socioeconomics;success;Techniques;Testing;tool;Training;United States;United States National Institutes of Health;user-friendly;web page;webinar;Work;working group;Writing

PROJECT_TITLE: Network on Education, Biosocial Pathways, and Dementia across Diverse Populations


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: We will develop a biomedical entrepreneurship training program to educate, train, broaden the skill set and motivate the scientific work force to promote healthy aging. Our “Biomedical Entrepreneurship Training for Aging” (BETA), will promote the work force towards translation of research ideas in aging, transform them as “innovative thinkers and entrepreneurial scholars,” and influence their career opportunities in healthcare sectors.

PI_NAMEs: UPENDRAN, ANANDHI  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Academia;Age Years;age-related disease;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral;Biological Sciences;Brain;Businesses;Capital;career;Cities;Clinical;Clinical Research;Cognitive;college;combat;commercialization;Communication;Complement;Complex;Delirium;Dementia;design;Development;Devices;Discipline;Discipline of Nursing;Disease;diversity and inclusion;Doctor of Philosophy;Ecosystem;Education;Elderly;empowerment;Engineering;Entrepreneurship;Evaluation Research;experience;Faculty;falls;Fellowship;frailty;Funding;Geriatrics;graduate student;Health;Health Care Sector;Health Occupations;Health system;Healthcare;healthy aging;higher education;human old age (65+);Human Resources;Immersion;improved;Incubators;Industrialization;Industry;innovation;Intellectual Property;Journalism;Kansas;Long-Term Care for Elderly;Longevity;Malignant Neoplasms;Marketing;medical schools;member;Mentors;Midwestern United States;Missouri;Modeling;Neurocognitive;Neurosciences;Neurosciences Research;novel;novel therapeutics;Older Population;Pathway interactions;Personal Satisfaction;Play;Population;post-doctoral training;Postdoctoral Fellow;Precision Health;Process;Productivity;programs;Quality of life;recruit;rehabilitation technology;Research;research clinical testing;Research Personnel;Research Training;responsible research conduct;Role;Schools;Science;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Source;Specialist;Stroke;Students;Syndrome;System;Talents;Technology;Technology Transfer;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Biomedical and Entrepreneurship Training for Aging (BETA)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Coronaviruses;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Over 1,000 genes have been implicated in autism spectrum disorder (ASD), but we don’t yet have a clear understanding of how each of those genes influences biology and behavior relevant to ASD. The proposed research uses an innovative strategy in a powerful animal model to understand if and how >100 of these genes, combinations of these genes, and gene variants from ASD patients cause changes to neurobiology and behavior.

PI_NAMEs: PIERCE, JONATHAN THOMAS (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Alleles;Animal Model;ASD patient;autism spectrum disorder;autism symptoms;axon guidance;Behavior;Behavioral;Biology;Breeding;Caenorhabditis elegans;causal variant;Cells;Certification;Classification;Collection;CRISPR/Cas technology;Cryopreservation;Databases;Defect;Development;Eating;empowerment;endophenotype;Family;Foundations;Future;Gene Combinations;gene conservation;Gene Expression Profiling;Gene Transfer Techniques;Genes;Genetic;genetic variant;genome wide association study;Goals;high risk;Human;Impairment;in vivo;in vivo Model;innovation;insight;Knowledge;Linear Regressions;model organism;Molecular;Molecular Genetics;Morphology;motor behavior;mutant;Mutation;Nematoda;neural circuit;Neurobiology;Neurologic;Neurons;novel;Orthologous Gene;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;Pilot Projects;Positioning Attribute;Research;Research Personnel;response;Risk;risk variant;Rodent;Rodent Model;Sensory;sensory integration;Severities;social;Social Behavior;Social Change;social deficits;social influence;social integration;Socialization;Stimulus;Structure;symptom treatment;Synapses;SYNGAP1;Testing;Time;Transgenic Organisms;Variant;variant of unknown significance;Williams Syndrome;Work

PROJECT_TITLE: High-throughput interrogation of autism risk genes: from molecules to behavior

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Tumor cells encounter many types of stress, such as nutrient scarcity, throughout disease progression that can promote adaptation and resilience but may also yield tumor-specific therapeutic vulnerabilities. The research proposed here describes a novel response to nutrient stress. Studying this stress response mechanism and understanding how it is employed by the cancer cell to support disease progression may thus facilitate the development of cancer therapeutics aimed at exploiting this response.

PI_NAMEs: BLENIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Attention;Binding;biological adaptation to stress;cancer cell;Cell Communication;Cells;cost;Cysteine;Data;deprivation;deprotonation;Detection;Development;Disease Progression;Ensure;Environment;Environmental Risk Factor;Event;extracellular;Frequencies;Global Change;Glutamine;glycosylation;glycosyltransferase;Growth;Hexosamines;Immune Evasion;Iodoacetamide;Knock-out;Label;Malignant Neoplasms;Mediating;Metabolic;Modification;N-Acetylglucosamine kinase;Neoplasm Metastasis;neoplastic cell;novel;Nucleotides;Nutrient;Nutrient Depletion;Oxidants;oxidation;Pathway interactions;Perfusion;Phosphorylation;Phosphotransferases;Polysaccharides;Predisposition;Process;programs;Property;Proteins;Proteome;protonation;Reaction;Recycling;Regulation;Research;resilience;Resources;response;Role;Signal Transduction;Site;small molecule;Stimulus;Stress;sugar;sugar nucleotide;Sulfhydryl Compounds;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;uptake;Work

PROJECT_TITLE: The role of NAGK cysteine deprotonation in nutrient stress and cancer progression


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Our studies are designed to lay the groundwork for novel therapeutic approaches to improve the outcomes of liver transplantation and other clinical conditions with hepatic ischemia reperfusion (IR) injury, such as liver resection, hemorrhagic shock and trauma. We uncovered a previously unappreciated function of eosinophils in promoting liver repair after IR injury. If successfully completed, the proposed studies will elucidate the underlying molecular mechanisms and provide strong evidence supporting the therapeutic potential of eosinophils in accelerating liver recovery after transplantation.

PI_NAMEs: JU, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acceleration;Acute;acute liver injury;Adoptive Transfer;Allografting;Animals;Antibodies;Bone Marrow;CCL24 gene;Cell Therapy;Cells;cellular targeting;Clinical;clinical practice;Data;design;DTR gene;Endothelial Cells;eosinophil;Epidermal Growth Factor Receptor;Excision;Exhibits;experimental study;Funding;Goals;Hemorrhagic Shock;Hepatic;Human;human tissue;Impaired wound healing;Impairment;improved;improved outcome;Injury;insight;Interleukin-13;Interleukin-4;ischemic injury;Kupffer Cells;Liver;Liver Dysfunction;liver injury;liver ischemia;Liver Regeneration;liver repair;liver transplantation;Macrophage;Measures;Modeling;Molecular;Mus;Natural regeneration;neutrophil;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organ Donor;Phase;Play;Predisposition;Production;Productivity;receptor;Recovery;recruit;Regulation;repair function;Reperfusion Injury;Reperfusion Therapy;Reporting;Resolution;Role;Signal Transduction;Therapeutic;Time;tissue regeneration;tissue repair;translational model;translational study;Transplantation;Transplantation Surgery;Trauma

PROJECT_TITLE: Role of Eosinophils in Hepatic Ischemia Reperfusion Injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Although the pathophysiology of Alzheimer’s Disease (AD) is complex and multifactorial, vascular comorbidities and cerebrovascular insufficiency occur in almost two-thirds of AD patients. However, how cerebrovascular insufficiency interacts with and contributes to AD remains poorly understood. In response to RFA-AG-23-014 (Mechanisms of Brain Hypoperfusion in AD/ADRD), we propose to test the hypothesis that cerebrovascular insufficiency perturbs the AD brain vasculome, eventually leading to cognitive impairment.

PI_NAMEs: ARAI, KEN  (contact);LO, ENG H.;SAKADZIC, SAVA

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: age group;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;angiogenesis;awake;Blood Vessels;Brain;brain endothelial cell;Carotid Stenosis;Cell Culture Techniques;cell type;Central Nervous System Diseases;cerebral hypoperfusion;Cerebrovascular Circulation;Cerebrovascular Insufficiency;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;cognitive function;Common carotid artery;comorbidity;Compensation;Complex;Data;Dependence;design;Disease Progression;Endothelial Cells;Endothelium;Exhibits;experimental study;Female;Functional disorder;Genes;Homeostasis;hypoperfusion;Impaired cognition;Impairment;improved;In Vitro;in vivo;Knock-out;Knockout Mice;Knowledge;male;Measures;Mediating;Methods;mouse model;multidisciplinary;Mus;novel;object recognition;Optical Coherence Tomography;Outcome;Pathology;Pericytes;Peripheral;Phase;Physiological;Recovery;response;Sleep;Testing;transcriptome;transcriptome sequencing;two photon microscopy;Vascular remodeling

PROJECT_TITLE: The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Patient Safety

ORG_CITY: Naperville

ORG_NAME: APT THERAPEUTICS, INC.

ORG_STATE: IL

PHR: Principal Investigator/Program Director (Last, First, Middle: Chen, Ridong NARRATIVE  We will determine whether treatment with a novel thrombus-targeting fusion protein is more effective in attenuating microvascular obstruction and protecting hearts in an established porcine model of acute myocardial infarction while reducing bleeding complications compared to the standard-of-care treatment with ticagrelor plus heparin.

PI_NAMEs: CHEN, RIDONG  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Activated Partial Thromboplastin Time measurement;Acute;Acute myocardial infarction;Adenosine;antagonist;Anticoagulants;Antiinflammatory Effect;Antithrombin III;ANXA5 gene;Apyrase;Aspirin;Attenuated;attenuation;Autologous;Benefits and Risks;Binding;Binding Sites;bivalirudin;Bleeding time procedure;Blood flow;Blood Platelets;Blood Vessels;cardioprotection;Carotid Arteries;Cause of Death;Cell membrane;Chimeric Proteins;Chronic;Circulation;Clinical;Clinical Trials;clinically relevant;clopidogrel;Competitive Binding;Coronary;Coronary Occlusions;Coronary Thrombosis;Data;Development;Dose;Dose Limiting;drug development;EFRAC;electrical injury;Endothelial Cells;Enoxaparin;experience;extracellular;factor IXa-factor VIIIa;Fibrinolytic Agents;Functional disorder;Generations;Good Manufacturing Process;Heart;Heart failure;heart function;Hemorrhage;Heparin;Homologous Gene;Human;improved;improved outcome;Infarction;Inflammation;Inflammatory;inhibitor;Injections;injured;innovation;Left Ventricular Remodeling;Left ventricular structure;Legal patent;Leukocytes;Life;Link;Low-Molecular-Weight Heparin;manufacture;manufacturing process;Mediating;Membrane;Microcirculation;Modeling;mortality;myocardial damage;Myocardial Infarction;Myocardial perfusion;Myocardium;novel;novel therapeutics;Obstruction;Oryctolagus cuniculus;Outcome;patient prognosis;Patients;percutaneous coronary intervention;pharmacologic;Phase;Phosphatidylserines;Platelet Activation;porcine model;preclinical study;prevent;Principal Investigator;programs;protein expression;Proteins;prothrombinase complex;Radial;Recommendation;Recurrence;Reperfusion Injury;Reperfusion Therapy;research clinical testing;restoration;Risk;Safety;safety study;Site;Small Business Innovation Research Grant;standard of care;Therapeutic Embolization;Thrombin;thrombogenesis;Thrombosis;thrombotic;Thrombus;Toxic effect;Treatment Protocols;vascular inflammation;vascular injury;Work

PROJECT_TITLE: Multi-functional anti-thrombotic therapy for coronary microvascular obstruction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IVBH-V(10)]