NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Most experts advocate for early detection of cognitive impairment (CI) so that patients and caregivers can be prepared for making difficult decisions and to improve quality of life, but studies show that screening alone isn’t sufficient to change clinician actions related to early detection. Using predictive modelling developed with machine learning methods and sophisticated clinical decision support (CDS) tools, it is possible to identify patients at elevated risk for CI and make it much easier for primary care to engage and support patients and caregivers in meaningful care planning. In this project, we implement and evaluate a low-cost, highly scalable CI-CDS system integrated within the electronic health record that has high potential to improve early CI detection and care and translate massive public and private sector investments in health informatics into tangible health benefits for large numbers of people.

PI_NAMEs: HANSON, LEAH R (contact);ROSSOM, REBECCA CLARE

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Accident and Emergency department;Address;Adult;Advocate;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;behavior change;cardiovascular risk factor;care systems;Caregivers;Caring;Chronic Disease;Clinic;Clinical;clinical decision support;Clinical Decision Support Systems;clinical effect;cost;Data;Decision Making;Dementia;dementia risk;Detection;Diabetes Mellitus;Diagnosis;Disparity;Distress;Documentation;Early Diagnosis;Electronic Health Record;electronic health record system;Ethnic Origin;evidence base;Family;Feeling;follow-up;Foundations;Future;Gender;Guidelines;Health Benefit;health care service utilization;Health Expenditures;Impaired cognition;improved;improved outcome;indexing;Individual;Inpatients;Intervention;intervention effect;Interview;Investments;Machine Learning;machine learning method;machine learning model;Managed Care;Medical;Medicare;mild cognitive impairment;Newly Diagnosed;Office Visits;Online Systems;Patient Care Planning;patient engagement;Patient-Focused Outcomes;Patients;personalized care;personalized decision;Persons;Phase;pilot test;pragmatic trial;predictive modeling;Predictive Value;Prevalence;Primary Care;primary care clinic;primary care clinician;Printing;Private Sector;prototype;Public Health Informatics;Public Sector;Publishing;Quality of life;Race;Randomized;randomized trial;Readiness;Recommendation;Reporting;response;Risk;satisfaction;screening;sociodemographic disparity;Socioeconomic Status;Specialist;Standardization;Stress;success;Suggestion;support tools;Surveys;Technology;Telephone;Theory of Change;tool;Translating;treatment as usual;Visit;wellness visit;Work

PROJECT_TITLE: A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Adults with congenital heart disease (ACHD) are a newly emerging population who are at high risk for poor health care outcomes since majority of them are lost to ongoing specialist care after they transition from pediatric to adult health care system. With advances in mHealth for behavioral modification, we seek to understand the facilitators and barriers to their use, and leverage these technological advances to increase skills for ACHD patient engagement and facilitate ongoing ACHD specialist care.

PI_NAMEs: AGARWAL, ANUSHREE  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adult;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Model;Boston;care costs;care outcomes;career development;Caring;Cellular Phone;Child health care;Childhood;Chronic;Chronic Disease;Clinic;Clinical;Clinical Trials;Conduct Clinical Trials;congenital heart abnormality;Data;Dedications;design;Development;Development Plans;Education;effectiveness evaluation;Ensure;Event;experience;Failure;Family Planning;Feedback;Fostering;Funding;Future;Goals;Health;Health Services;Health system;Healthcare;Healthcare Systems;high risk;improved;Infrastructure;Institution;Intervention;intervention refinement;Interview;Knowledge;Knowledge Management;Life;Measures;Medical;Medical Care Team;Mentors;Mentorship;mHealth;mhealth interventions;mobile application;mortality;Motivation;multidisciplinary;Nurses;Occupations;Outcome;Patient Care;patient engagement;Patients;Pediatric cardiology;Pilot Projects;Population;Positioning Attribute;Process;programs;prospective;Provider;psychosocial;Qualitative Methods;randomized, controlled study;Research;Research Personnel;Resources;Risk;San Francisco;Self Efficacy;Self Management;skill acquisition;skills;Specialist;Structure;success;Surveys;Technology;Testing;theories;therapy design;Time;Training;Travel;United States National Institutes of Health;user-friendly;Visit;Vocation;Washington;willingness

PROJECT_TITLE: Improving transitions of care for adults with congenital heart disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of our research is to understand the mechanism and genomics of excision repair, the molecular mechanism of the mammalian circadian clock, and the regulation of repair by the circadian clock to develop mechanism-based strategies for cancer prevention and treatment.

PI_NAMEs: SANCAR, AZIZ  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative: Although pathology is at the foundation of medicine, it is traditionally an analog process, and current technologies to digitize pathology slides have been slow to be adopted, limiting the potential impact of digital pathology assistance in routine clinical pathology to enhance diagnosis and prognosis. In this project, we will develop a low-cost Computer Aided Microscope to bring real-time digital pathology image generation and assistance into the standard clinical workflow, by leveraging onboard cameras on clinical pathology microscopes to capture and document clinical glass slide reviews into data-efficient variable resolution images and associated attention maps, enabling pathologists to see and analyze “the whole picture” at the time of slide diagnosis.

PI_NAMEs: BROWN, JONATHAN QUINCY (contact);SUMMA, BRIAN

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adopted;Adoption;Algorithms;analog;Artificial Intelligence;artificial intelligence algorithm;Attention;Behavior;cancer diagnosis;Clinical;clinical diagnosis;clinical implementation;Clinical Pathology;clinical practice;Collaborations;Collection;Color;Computer Analysis;Computer Assisted;Computer software;Computer Vision Systems;Computers;Consultations;cost;Cytopathology;Data;Data Collection;data exchange;data pipeline;Data Storage and Retrieval;Decision Support Systems;Dedications;Detection;Development;Diagnosis;Diagnostic;digital;digital data;digital imaging;digital pathology;Equilibrium;Equity;Evaluation;Feedback;Feeds;Foundations;Future;Generations;Glass;Goals;graph theory;Head;Heart;Histopathology;Hospitals;Human;Human Resources;human-in-the-loop;Image;image reconstruction;image registration;Imagery;imaging biomarker;imaging system;Imaging technology;improved;innovation;insight;instrumentation;learning algorithm;lens;machine learning algorithm;Malignant neoplasm of prostate;Maps;Medicine;Methods;Microscope;Microscopy;mosaic;multidisciplinary;novel;open source;Outcome;Pathologist;Pathology;pathology imaging;Patients;Performance;precision medicine;Process;Prognosis;Radiology Specialty;real-time images;Records;Recovery;Remote Consultation;Research;Resolution;Sampling;Scanning;Second Opinions;self supervised learning;shape analysis;signal processing;Slide;spatiotemporal;Stream;System;Technology;Testing;Time;Tissue imaging;Tissue Sample;Visualization;whole slide imaging;Work

PROJECT_TITLE: PathCAM: connecting the digital data pipeline in diagnostic pathology with onboard-camera variable resolution slide imaging


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Palliative care is an effective means of improving quality of life for patients with incurable diseases. However, racial disparities exist in the utilization of palliative care services, with African American patients significantly less likely than white patients to access or receive palliative care – a factor that can result in African American patients failing to receive care aligned with their goals and wishes. We will examine an approach that integrates the support of Community Health Workers – non-clinician public health workers who provide culturally sensitive health education, information, and advocacy – to enhance palliative care among African American patients with advanced cancer.

PI_NAMEs: JOHNSTON, FABIAN M (contact);MATHUR, AARTI

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Address;Administrator;Adoption;Advance Care Planning;Advanced Malignant Neoplasm;Advocacy;Advocate;African American;African American population;American Society of Clinical Oncology;Awareness;barrier to care;cancer care;Cancer Center;care delivery;care outcomes;care systems;Caregivers;Caring;Chronic Disease;Communication;Communities;Community Health Aides;Community Healthcare;compare effectiveness;Complement;Conflict (Psychology);Consolidated Framework for Implementation Research;contextual factors;cultural competence;cultural values;design;Development;Disease;Disparity;disparity reduction;Dissemination and Implementation;Documentation;Economic Factors;Education;Effectiveness;effectiveness-implementation randomized trial;empowerment;end of life;end of life care;end of life outcomes;Enrollment;Ensure;ethnic disparity;Evaluation;evidence base;Evidence based practice;experience;Family;family burden;Focus Groups;Funding;Goals;Health;health care delivery;health care disparity;Health education;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;HIV/AIDS;Home;hospice environment;hospice utilization;Hospitals;Hybrids;implementation barriers;implementation evaluation;implementation facilitation;implementation intervention;implementation/effectiveness;Improve Access;improved;Individual;informant;Intervention;intervention refinement;Interview;Investigation;Knowledge;Link;Malignant Neoplasms;Medical Care Team;member;Methods;Modeling;Motivation;Oncologist;Outcome;Pain management;palliative;Palliative Care;Patient advocacy;Patient Care;Patients;Persons;Philosophy;physical symptom;Physicians;Pilot Projects;Population;pragmatic trial;process evaluation;psychological symptom;Public Health;Quality of Care;Quality of life;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;research to practice;Resources;Role;satisfaction;Scanning;Services;Site;skills;social health determinants;Social Work;standard care;successful intervention;System;Techniques;Training;Tuberculosis;underserved community;Underserved Population;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Dissemination and Implementation of a Community Health Worker Intervention for Disparities in Palliative Care (DeCIDE PC)

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Genetics;Immunotherapy;Inflammatory Bowel Disease;Liver Disease;Nutrition

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Project Narrative The gut is central to immune development, tolerance and regulation. However, current paradigms in the field tend to conflate the two distinct organs comprising ‘the gut’—small and large intestines—and our labs have established that T cells infiltrating these discrete intestinal segments leverage distinct sets of ligand-regulated nuclear receptors (NRs) to tether local regulatory functions to select host- and microbe-derived metabolite classes. By generating new molecular insight into the mechanisms by which established (VDR) and novel (CAR) NR pathways regulate T cell homeostasis in the small vs. large intestines, our proposal will establish novel biological paradigms and inform the treatment of human inflammatory bowel diseases (IBDs).

PI_NAMEs: SUNDRUD, MARK SCOTT (contact);WEAVER, CASEY T

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: absorption;Anti-Inflammatory Agents;Antigens;Bacteria;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Bile fluid;Biochemical;Biological;Biological Assay;Butyrates;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cholecalciferol;Circulation;Clinical Management;Clinical Research;constitutive androstane receptor;Crohn's disease;cytokine;cytotoxic;Data;Detergents;Development;Drug Metabolic Detoxication;Duodenum;effector T cell;Enteral;Enterocytes;Enterohepatic Circulation;Enzymes;epidemiology study;Fostering;FOXP3 gene;Gallbladder;Gene Expression;Genes;Genetic Transcription;Hepatobiliary;Hepatocyte;Histone Deacetylase Inhibitor;Homeostasis;host-microbe interactions;Human;IL10 gene;Ileitis;ileum;Immune;immune function;Immune Tolerance;Immunologics;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-10;Intestines;Large Intestine;Libraries;Ligands;Link;lipophilicity;Liver;Maintenance;Mediating;Metabolism;Microbe;microbial;Molecular;mouse model;Mucous Membrane;murine colitis;Mus;novel;Nuclear Receptors;Organ;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;prevent;programs;Publishing;receptor expression;receptor function;Recombinant Proteins;Refractory;Regulation;Regulatory T-Lymphocyte;Reporting;Residual state;Resolution;response;sensor;Shapes;Signal Transduction;small bowel Crohn's disease;Small Intestines;synergism;T cell infiltration;T cell reconstitution;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Tissues;Toxic effect;Transcriptional Regulation;Ulcerative Colitis;Vitamin D3 Receptor;Volatile Fatty Acids;Work

PROJECT_TITLE: Nuclear Receptor Control of T Cell Function in Discrete Intestinal Microenvironments

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Leveraging the Boston Lung Cancer Survival Cohort (BLCSC), one of the largest lung cancer cohorts globally, we develop methods with a common goal of effectively identifying racial disparities in cancer outcomes by integrating high dimensional observational studies with multiple racial groups. Our methods facilitate integrative, unconfounded detection of racial disparities in cancer outcomes, and generalization to a realistic and inclusive larger population.

PI_NAMEs: GUHA, SUBHARUP ;LI, YI  (contact)

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Accounting;African American population;Asian population;Bayesian Modeling;Biological Factors;Boston;cancer health disparity;Cancer Patient;cancer survival;Cations;Caucasians;Cause of Death;Censuses;Cessation of life;Clinical;cohort;Compensation;Complex;Computer software;Country;Dana-Farber Cancer Institute;Data Set;data structure;Databases;density;design;Detection;Diagnosis;dietary;Disparity;DNA;DNA Sequence Alteration;Equilibrium;Equity;ethnic disparity;Ethnic Origin;flexibility;Fostering;General Hospitals;Genetic;Goals;Health;health care availability;Health Disparities Research;high dimensionality;improved;Inequity;innovation;interest;International;Knowledge;Leukocytes;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Massachusetts;Mayo Clinic Cancer Center;Methods;minority patient;multiple omics;Mutation;mutational status;novel;Observational Study;Oncogenic;open source;Outcome;Pathology;Patients;Population;Population Characteristics;Procedures;Process;Property;Race;racial disparity;racial minority;racial minority population;racial population;Research;Research Design;Research Personnel;Sample Size;screening;Serum;Smoking;social;social determinants;social disparities;Stage at Diagnosis;Structural Racism;Target Populations;Tumor Tissue;Uncertainty;United States National Institutes of Health;Weight

PROJECT_TITLE: Detecting racial disparities in cancer survival by integrating multiple high-dimensional observational studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_DEPT: PHARMACOLOGY

PHR: Carboxylesterase 1 is the primary hydrolase responsible for the metabolism of many clinically important medications in the liver. The project is to study whether plasma carboxylesterase 1 protein could be used as a biomarker to tailor drug therapy to individual patients. The study holds the potential to improve the safety and efficacy of many drugs metabolized by the enzyme.

PI_NAMEs: ZHU, HAOJIE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Affect;aldehyde dehydrogenases;Area;Biological Assay;Biological Markers;Biopsy;Carboxylesterase 1;Catechol O-Methyltransferase;Clinical;clinically significant;Code;Data;design;Distant;Dose;Drug Kinetics;drug metabolism;Effectiveness;Enalapril;Enzymes;Exhibits;Exposure to;Frequencies;Gene Frequency;Genes;Genetic Markers;genetic variant;Hepatic;Human;Hydrolase;improved;in vivo;Individual;individual patient;inter-individual variation;Literature;Liver;loss of function;Lung;Measures;medication safety;Metabolism;Minor;Nucleic Acid Regulatory Sequences;Outcome;Patients;Pharmaceutical Preparations;Pharmacogenetics;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Plasma;Plasma Proteins;potential biomarker;predictive marker;protein biomarkers;protein expression;Proteins;Proteomics;Publishing;Regimen;Reporting;response;Ritalin;Safety;Sampling;sulfotransferase;Therapeutic;Therapeutic Agents;Therapeutic Index;therapy outcome;Time;Tissues;Toxic Environmental Substances;Variant

PROJECT_TITLE: Carboxylesterase 1 Plasma Biomarker for Precision Pharmacotherapy

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: The proposed research is relevant to public health because alterations in thin filament lengths in muscle sarcomeres have been linked to the development of myopathies. In this study, the regulatory role of leiomodin in thin filament organization and function will be studied.

PI_NAMEs: GALKIN, VITOLD ;GREGORIO, CAROL C;KOSTYUKOVA, ALLA S. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Affect;Animals;Architecture;Arizona;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;biophysical properties;Biophysics;C-terminal;Cardiac;cardiac muscle disease;Cardiac Myocytes;Cellular biology;Clinical;combat;Complex;Cryoelectron Microscopy;Crystallography;Data;Development;Developmental Biology;Diagnostic;Disease;experimental study;Family;Fluorescence Resonance Energy Transfer;Functional disorder;Goals;Health;improved;In Vitro;in vivo;Interdisciplinary Study;Knockout Mice;Laboratories;Learning;Length;Link;Maintenance;medical schools;Methods;Microfilaments;Minus End of the Actin Filament;Modeling;Molecular;Molecular Biology;Molecular Conformation;Monitor;monomer;Muscle;Muscle Fibers;Muscle Weakness;muscular structure;Mutate;Mutation;Myocardium;Myofibrils;Myopathy;Myosin ATPase;new therapeutic target;novel;Nuclear Magnetic Resonance;Organ;Physiology;prevent;Protein Fragment;protein structure;Proteins;Public Health;Regulation;Research;Resolution;Role;Sarcomeres;Side;Site;Skeletal Muscle;Slide;Striated Muscles;structural biology;Structural Models;Structure;Testing;Thick Filament;Thin Filament;Time;tropomodulin;Tropomyosin;Troponin;Universities;vector;Virginia;Washington

PROJECT_TITLE: REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASE

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Preliminary data have identified the presence of the transmembrane immune checkpoint protein programmed death-ligand 1 (PD-L1) in β cell exosomes, with increased PD-L1 loading in response to inflammatory cytokine treatment of parent β cells. The goals of this project are to: 1) Define molecular signaling pathways regulating β cell PD- L1 exosome cargo under diabetogenic conditions; 2) Determine the functional relevance of specific β cell exosome PD-L1 cargo transfer to surrounding β cells and T cells; and 3) Define relevance of altered exosome PD-L1 cargo to human T1D. This work will address a critical gap in knowledge regarding β cell exosome biology and has the potential to inform novel diagnostic strategies aimed at dissecting heterogeneity in T1D.

PI_NAMEs: EIZIRIK, DECIO LAKS;EVANS-MOLINA, CARMELLA ;MIRMIRA, RAGHAVENDRA G;SIMS, EMILY K (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Antibody Therapy;Antigens;Apoptosis;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;Autoimmunity;Beta Cell;Binding;Biogenesis;Biological Markers;Biology;C-Peptide;CD8-Positive T-Lymphocytes;Cell Communication;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular Stress;Cessation of life;Chemicals;Clinical;clinical biomarkers;cytokine;Cytotoxic T-Lymphocytes;Data;density;Development;diabetogenic;diagnostic strategy;Disease;Etiology;Exocytosis;exosome;extracellular vesicles;genetic manipulation;Goals;Health;Heterogeneity;Housing;Human;human induced pluripotent stem cells;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune mediated destruction;In Vitro;in vivo;Inbred NOD Mice;Incidence;Individual;Inflammatory;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interferons;Intervention;Intravenous;islet;islet cell antibody;Knowledge;Link;Lymphocyte;Mediator;Membrane;Messenger RNA;Microfluidic Microchips;Molecular;Multivesicular Body;nanoparticle;neoplastic cell;non-diabetic;novel;novel diagnostics;novel marker;overexpression;Pancreas;paracrine;Parents;Pathway interactions;Persons;Physiological;Plasma;Play;Pre-Clinical Model;preservation;prevent;programmed cell death ligand 1;programmed cell death protein 1;Proteins;receptor;Regulation;Research;Residual state;response;Risk;Signal Pathway;Signal Transduction;Slice;Specificity;Sphingomyelinase;Stimulus;Stress;stressor;Surface;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;therapeutic target;transcription factor;uptake;Work

PROJECT_TITLE: Implications of Changes in Islet Exosomal Cargo in Type 1 Diabetes


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH This project is a continuation of a collaboration which aims to develop new tools and approaches for imaging the microvasculature with ultrasound. Data suggests that imaging the microvasculature will provide us with an improved ability to detect and differentiate cancer in humans, and if successful, our approach may lead to a new low-cost, safe, portable imaging modality that is better at early detection of cancers than currently available modalities. To pursue this, we will develop new ultrasound hardware and imaging approaches, and test their performance in preclinical and clinical populations.

PI_NAMEs: DAYTON, PAUL A (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Achievement;Acoustics;Algorithms;angiogenesis;Angiography;animal imaging;animal tissue;Area;Biological Markers;Biomedical Engineering;Blood Vessels;breast lesion;cancer biomarkers;Clinical;clinical application;clinical imaging;clinical translation;Clinical Trials;Collaborations;contrast enhanced;contrast imaging;Contrast Media;cost;Data;density;design;Detection;Development;Devices;Diagnostic;Disease;Early Diagnosis;fabrication;Frequencies;Future;Genetic Predisposition to Disease;Goals;Human;human imaging;human tissue;Image;imaging approach;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;indexing;industry partner;innovative technologies;lens;Lesion;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mammary Neoplasms;Mechanics;Microbubbles;Modality;Modeling;molecular imaging;molecular marker;Motion;Mus;new technology;next generation;Noise;novel;Patients;Penetration;Performance;performance tests;Population;portability;pre-clinical;Process;Productivity;prototype;Public Health;Receiver Operating Characteristics;Recovery;Renal Carcinoma;Research;Resolution;Rodent;Screening for cancer;Sensitivity and Specificity;Signal Transduction;spatiotemporal;Specificity;Structure;superresolution imaging;System;Techniques;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tool;Transducers;Translations;transmission process;treatment response;ultra high resolution;Ultrasonography;ultrasound;Universities;Validation;Visualization;volunteer

PROJECT_TITLE: Academic-Industrial Partnership for Translation of Acoustic Angiography

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MANHATTAN

ORG_DEPT: BIOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Relevance of this research to public health: The results of this study will contribute to fundamental understanding of control of mRNA translation at the level of start codon selection, which is vital to understanding of normal and cancer cell regulation.

PI_NAMEs: ASANO, KATSURA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Adenosine;Affect;Anticodon;Automobile Driving;Base Pairing;Binding;Biological;biological adaptation to stress;Biological Models;c-myc Genes;cancer cell;Cancer Model;cancer type;carcinogenesis;Cell Survival;Codon Nucleotides;Complex;Cues;Data;Development;differential expression;Disease;disorder prevention;Elements;Enzymes;Eukaryota;Eukaryotic Cell;Eukaryotic Initiation Factors;Exclusion;flexibility;Gene Expression;genetic regulatory protein;genome-wide;Genomic approach;Grant;Heat-Shock Response;High temperature of physical object;Human;Human Genome;Human Papillomavirus;Immune;Initiator Codon;insight;Knowledge;Learning;Life;Malignant Neoplasms;Messenger RNA;Methods;Mitotic Cell Cycle;Modeling;molecular dynamics;mRNA Translation;mutant;Mutation;Neurodegenerative Disorders;Neurons;neurotoxic;Normal Cell;novel;Oncogenes;Oncogenic;Outcome;patient prognosis;Patient-Focused Outcomes;Peptides;Periodicity;Phase;Process;Production;Protein Biosynthesis;Proteins;Public Health;recruit;Regulation;Repression;Research;response;Ribosomes;RNA Binding;Role;Saccharomyces cerevisiae;Scanning;Side;Site;stem;Stimulus;Testing;Translation Initiation;Translational Regulation;Translations;Yeasts

PROJECT_TITLE: Mechanism of stringent translation initiation: a probe for its biological relevance

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Postbaccalaureate Scholars are funded to complete a mentored, 12 month research experience in a laboratory addressing a basic science question that is supplemented with training in critical thinking, leadership, and communication skills. Training includes mentored, original research in a laboratory, oral and written presentation skills, analysis of the scientific literature, critical thinking and evaluation, responsible conduct of research, and the principles of scientific rigor and reproducibility. Students also benefit from near peer mentoring, exposure to a range of career opportunities in science, and unique programming to support professional development that includes opportunities to relate the trainees' scientific interests to the broader community.

PI_NAMEs: BARNETT, JOEY VICTOR (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Awareness;Basic Science;biomedical scientist;career;Climacteric;Collaborations;Communication;Communities;community engagement;Credentialing;Critical Thinking;cultural competence;Development;Education;Evaluation;experience;experimental study;Exposure to;Fostering;Funding;Future;Goals;Immersion;Individual;innovation;interest;Knowledge;Laboratories;Leadership;Life;Literature;member;Mentors;Minority;Mission;National Institute of General Medical Sciences;next generation;Oral;Participant;Pathway interactions;peer;peer coaching;Perception;Policies;Postbaccalaureate;Process;Productivity;programs;Reproducibility;Research;Research Training;resilience;Resources;responsible research conduct;Rewards;Science;Shapes;skill acquisition;skills;social;Social Change;Students;Training;Training Programs;Trust;Underrepresented Populations;Universities;Vision;Work;Writing

PROJECT_TITLE: Vanderbilt Experimental Research Training Inclusion Community Engagement Skills (VERTICES)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


PHR: While lung transplantation promises improvements in survival, function, and quality of life for some end-stage lung diseases, survival after transplantation is limited by scarring in small airways. This proposal will leverage brushes of the small airways as a novel tool to understand how the abnormal blood supply to the transplanted lungs could lead to inflammation and destruction of airway progenitor cells. Success in this project will improve diagnosis of this lung scarring and allow for approaches to test treatments to prevent or reverse this disease.

PI_NAMEs: GREENLAND, JOHN  (contact);MARTINU, TEREZA ;MCDYER, JOHN F

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Activated Lymphocyte;Address;Affect;airway epithelium;Airway Fibrosis;Alloantigen;Anatomy;Apoptosis;apoptosis in lymphocytes;Apoptotic;Automobile Driving;Bioinformatics;Biometry;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Brush Cell;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Culture System;Cell Culture Techniques;Cell Death;Cell Hypoxia;Cell surface;cell type;Cells;chemokine;Chronic;Cicatrix;Circulation;clinical phenotype;clinical subtypes;Clinical Trials;cohort;Cohort Studies;Complement;cytokine;Cytolysis;Cytometry;cytotoxic;Cytotoxic T-Lymphocytes;Data;Detection;Development;Diagnosis;Disease;Distal;effector T cell;Epithelial Cells;Exposure to;Fibrosis;fibrotic lung;Flow Cytometry;Functional disorder;functional improvement;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Heat shock proteins;Hypoxia;Hypoxia Pathway;Image;Immune;Immune response;Immunity;Immunobiology;improved;In Vitro;Inflammation;Infrastructure;innovation;insight;Institution;Investigation;Kinetics;Ligands;Light;Link;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphocyte;Lymphoid Cell;Macrophage;Mediating;member;Methods;multidisciplinary;novel;novel marker;novel strategies;OX40;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Phenotype;Play;post-transplant;prevent;Prevention;Primary Cell Cultures;progenitor;programs;Proteins;Publishing;pulmonary function;Quality of life;recruit;Reporting;respiratory hypoxia;response;Role;segregation;Signal Transduction;single-cell RNA sequencing;Source;stem cells;Stimulus;Stress;Structure of parenchyma of lung;success;Surrogate Markers;synergism;T cell response;T-cell inflamed;T-Lymphocyte;targeted therapy trials;Techniques;Testing;Time;TNF gene;TNF-related apoptosis-inducing ligand;TNFRSF10A gene;TNFRSF5 gene;TNFRSF8 gene;TNFSF5 gene;tool;Transcript;transcriptome;transcriptome sequencing;translational research program;transplant centers;Transplant Recipients;Transplantation;Up-Regulation;Validation;Vascular blood supply;vascular inflammation

PROJECT_TITLE: Airway epithelial cell and lymphocyte interactions in chronic lung allograft dysfunction pathogenesis

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARATIVE As many as two-thirds of hematopoietic stem cell transplant (HCT) recipients experience persistent, clinically significant fatigue up to six years following HCT despite routine medical management. Existing behavioral interventions often fail to meet the needs of a post-HCT population by solely including patients with malignant underlying disease, focusing on a single target (e.g., exercise), or intervening during the peri-transplant period without consideration for long-term HCT survivors’ needs. A videoconferencing-based cognitive-behavioral intervention that addresses population-specific multifactorial contributors to persistent post-HCT fatigue may reduce fatigue and improve quality of life for HCT survivors.

PI_NAMEs: NELSON, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Address;Advisory Committees;Autologous Transplantation;Award;Behavior Therapy;Benign;Biometry;cancer care;Cancer Center;career;Caring;Chronic;Chronic Myeloid Leukemia;Chronically Ill;Clinical;Clinical assessments;Clinical Management;Clinical Psychology;clinical training;Clinical Trials Design;clinically significant;Cognitive Therapy;Complex;curative treatments;Data;design;Development;Disease;Doctor of Philosophy;efficacious treatment;efficacy evaluation;Enrollment;Ensure;evidence base;Evidence based intervention;Evidence based treatment;Exercise;exercise intervention;experience;Exposure to;Fatigue;Feedback;General Hospitals;Goals;Health;Hematological Disease;Hematology;Hematopoietic Stem Cell Transplantation;Heterogeneity;Homologous Transplantation;Immunocompromised Host;improved;Inflammatory;International;Intervention;intervention refinement;Intervention Studies;Interview;Journals;Life;Life Style;Literature;Malignant - descriptor;Massachusetts;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mortality;Nature;Oncology;Outcome;Pathway interactions;patient engagement;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Peer Review;Pilot Projects;Population;Population Intervention;Positioning Attribute;post-transplant;post-transplant disease;Psychologist;Psychology;Publications;Publishing;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;reduce symptoms;Relapse;Reporting;Research;Research Personnel;Sampling;Severities;skills;Social isolation;Stem cell transplant;Structure;Supportive care;symposium;Symptom Burden;symptomatic improvement;Symptoms;Testing;Therapeutic;Therapeutic Intervention;therapy development;Training;Transplant Recipients;transplant survivor;Transplantation;treatment as usual;treatment strategy;Tyrosine Kinase Inhibitor;United States;videoconference;Videoconferencing;Work

PROJECT_TITLE: Reducing Persistent Fatigue Following Hematopoietic Stem Cell Transplantation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Immunotherapy;Infectious Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: This project aimed at developing two new class of mAbs, eg, TCRm mAbs specific for HPV-E7 and pIRS2- derived epitopes in the context of HLA-A*02:01 molecule. If successful, this approach could bring a novel and widely applicable therapy to various human cancers.

PI_NAMEs: DAO, TAO  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: 3-Dimensional;Amino Acids;Antibodies;Antigen Presentation Pathway;Antigens;Biopsy;Bispecific Antibodies;cancer cell;Cell Line;Cell surface;Cervix Carcinoma;chimeric antigen receptor;Complex;cost;Cytotoxic agent;Development;Dose;Engineering;Epitopes;flexibility;Half-Life;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;HLA-A gene;Human;Human Papillomavirus;Immune;immunogenic;Immunotherapy;In Vitro;in vivo;Insulin Receptor;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mass Spectrum Analysis;Membrane Proteins;Methods;MHC Class I Genes;Molecular Conformation;Monoclonal Antibodies;Monoclonal Antibody Therapy;neoantigens;novel;Oncoproteins;Peptides;Pharmaceutical Preparations;Phosphopeptides;Phosphorylation;Proteins;Radiation;Reproducibility;Serine/Threonine Phosphorylation;side effect;Specificity;Structure;T cell therapy;T-Cell Receptor;Testing;Therapeutic;tool;Toxin;Treatment Efficacy;tumor;Tumor Antigens

PROJECT_TITLE: Developing therapeutic TCR mimic monoclonal antibodies for cancer


ADMINISTERING_IC: DA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) has caused a great social burden with a large rise of opioid-related mortality. Greater understanding of the underlying neurocircuitry of OUD may help to predict treatment response and target therapies. Through advanced neuroimaging techniques, this project will characterize neurocircuits underlying drug craving and attentional bias to drug cues, and determine their association with regional brain concentrations of the neurotransmitters GABA and glutamate.

PI_NAMEs: TAYLOR, BRIAN ALLEN (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Amygdaloid structure;Animals;Anterior;Attention;attentional bias;Biological Markers;Biology;Board Certification;Brain;Brain region;causal model;Centers for Disease Control and Prevention (U.S.);Cessation of life;cingulate cortex;Clinical;Cocaine use disorder;Corpus striatum structure;Coupling;craving;cue reactivity;Cues;Data;design;Development;Diagnosis;Disease;drug craving;Drug usage;Ethics;Extinction;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutamates;Goals;Heroin Users;Hippocampus;Human;Image;imaging study;indicated prevention;Insula of Reil;Intake;Knowledge;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurable;Measures;Medical;Mentors;Methods;Modality;Modeling;mortality;multimodality;Nature;neural circuit;neuroimaging;neuromechanism;neuronal circuitry;Neurons;Neurosciences;Neurotransmitters;Opioid;opioid use;opioid use disorder;Oxycodone;Pathway interactions;Patients;Pharmaceutical Preparations;Physics;Physiological;Physiology;Prediction of Response to Therapy;Prefrontal Cortex;public health emergency;Reaction Time;Relapse;relapse prediction;Reporting;Research;Research Personnel;research study;response;Rodent;Self Administration;Serotonin Agonists;Services;social;Societies;Stimulus;substance use;Substance Use Disorder;targeted treatment;Techniques;theories;tool;Training;Training Programs;United States;visual stimulus;Work

PROJECT_TITLE: Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases;Vaccine Related

PHR: Project Narrative/Public Health Relevance Statement  HPV infection rates are unacceptably high among both females (58%) and males (38%) aged 20-24 in the US and there is an urgent need to reduce HPV infection by providing catch-up HPV vaccination to young adults aged 18-26 years. We expect the study to identify effective components of a multi-level intervention to improve HPV vaccination uptake and provide important insights into HPV vaccination uptake among young adults. The study will have significant impacts on science and practice by inspiring future prevention approaches that include multiple levels of influence to improve HPV vaccinations, and by setting a new path to provide evidence-based strategies tailored for young adults aged 18-26 years to promote “catch-up” HPV vaccination and prevent HPV related cancer.

PI_NAMEs: LU, QIAN  (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 19 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;Age Years;aged;Area;Attitude;Behavior;burden of illness;Cancer Etiology;cancer invasiveness;cancer prevention;Centers for Disease Control and Prevention (U.S.);Childhood;college;Community Pharmacy;Cost of Illness;design;Disease;Dose;evidence base;Female;Financial Hardship;follow-up;Future;Gardasil;Goals;health care delivery;Healthy People 2020;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunity;Immunization;Immunization Programs;implementation intervention;improved;Individual;Individual Differences;infection rate;innovation;insight;Intention;Intervention;Knowledge;Literature;male;Malignant neoplasm of penis;Mediating;men;Methods;Minority;Modeling;Not Hispanic or Latino;novel;Online Systems;Persons;Pilot Projects;Population;Positioning Attribute;Predisposition;prevent;Prevention;Prevention approach;primary outcome;Public Health;public health relevance;Randomized;Reader;Recommendation;Research;Safety;Schools;Science;Self Efficacy;social group;social norm;Specific qualifier value;stakeholder perspectives;statistics;success;Surveys;Survivors;System;Teenagers;Testing;Texas;Theoretical model;theories;Treatment Efficacy;United States;university student;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccine access;web-based intervention;Woman;Writing;young adult;young man;young woman

PROJECT_TITLE: Promoting HPV Vaccination among Young Adults in Texas

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_DEPT: DENTISTRY

PHR: Project Narrative Functional healing of oral defects remains unpredictable and understanding the physiological mechanisms that guide bone marrow biology and inflammatory resolution will increase the therapeutic reliability of these regenerative techniques in the future. This study aims to characterize the GAS6 pathway related to oral tissue regeneration. These studies may lead to new therapeutic strategies to treat periodontal bone defects and elucidate essential pathways in bone physiology of systemically compromised patients.

PI_NAMEs: DECKER, ANN MARIE (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Alveolar;alveolar bone;Apoptotic;Award;Biology;bone;Bone Marrow;Bone Regeneration;bone repair;Bone Tissue;Bone Transplantation;career;Cells;cohort;conditional knockout;Data;Dedications;Defect;Dental;Differentiation and Growth;Disease;edentulism;Epithelium;Esthetics;experimental study;extracellular;Future;Generations;Genetic;Goals;Growth;healing;Hematopoietic;Immune;Immunology;Impairment;Inflammation;Inflammatory;Injury;loss of function;Macrophage;Measurement;Mediating;Mesenchymal;Mesenchymal Stem Cells;Modeling;Monitor;Morphology;mouse model;Mus;Natural regeneration;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral cavity;oral tissue;Osteoblasts;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Positioning Attribute;Process;Production;Quality of life;regenerative;regenerative approach;Regulation;repaired;Resolution;Role;Scientist;side effect;Signal Transduction;soft tissue;Source;standard of care;targeted treatment;Testing;Therapeutic;thrombogenesis;tissue regeneration;Tissues;tool;Tooth Loss;Training;Trauma;Traumatic injury;Work;wound closure;wound healing

PROJECT_TITLE: GAS6-mediated alveolar bone regeneration


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: MADISON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The purpose of the CP-CTNet site at the University of Wisconsin Carbone Cancer Center Chemoprevention Program (UWISC) is to promote and conduct research in early phase cancer prevention trials (Phase 0, 1, 2) in order to determine potential viable prevention agents for at-risk populations. The CP-CTNet site will serve as the main organization to develop, design, conduct and analyze early phase prevention trials. The CP-CTNet site will use novel or re-purposed agents in various target organs to investigate their effects on pertinent biomarkers with the overarching goal of reducing the cancer burden by preventative measures.

PI_NAMEs: BARROILHET, LISA M (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;Alaska Native;Award;Biological;Biological Markers;Cancer Burden;cancer care;Cancer Center;cancer chemoprevention;cancer clinical trial;Cancer Patient;cancer prevention;Cancer Prevention Trial;cancer therapy;Chemoprevention;Chemopreventive Agent;Clinic;Clinical;Clinical Chemoprevention;clinical effect;Clinical Trials;Clinical Trials Network;clinically relevant;clinically significant;Collaborations;cost effective measures;design;Development;Division of Cancer Prevention;Dose;drug repurposing;Dysplasia;epidemiologic data;experience;first-in-human;Formulation;Funding;Genetic Predisposition to Disease;Goals;healthy volunteer;high risk;high risk population;Histologic;Immunologics;Immunoprevention;improved;Individual;Infrastructure;innovation;Institution;Intervention;Investments;Lead;Malignant Neoplasms;Medical center;medical specialties;member;Minority Groups;Molecular Target;multidisciplinary;National Cancer Institute;Neoplasms;novel;Organ;Organizational Affiliation;Participant;Patients;Performance;Pharmacodynamics;Phase;phase I trial;pilot trial;Population;Populations at Risk;Positioning Attribute;prevent;Prevention;prevention clinical trial;Prevention program;Prevention trial;Preventive;Preventive measure;Principal Investigator;Process;Productivity;Puerto Rico;Recommendation;Recording of previous events;Reproducibility;Research;research clinical testing;Research Personnel;Risk;Science;Screening procedure;Site;Special Population;targeted agent;Testing;Time;Tissues;tumor progression;Underrepresented Minority;Universities;vaccine trial;Vaccines;Wisconsin

PROJECT_TITLE: The MW Cancer Prevention Clinical Trials Network


PHR: RELEVANCE (See instructions): The systemic control of innate immunity is critical because inflammation accounts for the major physiological, metabolic, and pathological responses to infections. We plan to continue our studies to clarify the role of the nervous system in the regulation of intestinal innate immune responses against bacterial pathogens. A better understanding of the neural-immune communication could lead to new therapeutic targets for diseases involving a deficient innate immune system.

PI_NAMEs: ABALLAY, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Ablation;Affect;Alzheimer's Disease;Animals;Award;C. elegans genome;Caenorhabditis elegans;Calcium;Cells;Chemistry;Collaborations;Communication;communication behavior;Crohn's disease;Cues;Disease;Endocrine;experimental study;G-Protein-Coupled Receptors;gene function;Genes;genetic analysis;genetic approach;Germ Lines;Goals;gut colonization;Homeostasis;Immune;immune activation;Immune response;Immune system;Immunity;Immunologic Memory;immunoregulation;Individual;Infection;Inflammation;Innate Immune Response;Innate Immune System;insight;Instruction;intergenerational;Intestines;Knowledge;Ligands;Link;Malignant Neoplasms;Mammals;Mediator;Metabolic;microbicide;microbiota;Monitor;mutant;Natural Immunity;Nature;Nematoda;Nervous System;neural;neural circuit;neural stimulation;neuromechanism;Neurons;Neuropeptides;Neurophysiology - biologic function;neuroregulation;Neurosecretory Systems;Neurotransmitters;new therapeutic target;next generation;Nobel Prize;Organism;pathogen;pathogen exposure;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;Pharmaceutical Preparations;Physiological;Physiological Processes;Physiology;Play;Process;receptor;receptor function;receptor-mediated signaling;Regulation;Resources;response;Rheumatoid Arthritis;Role;sensor;Signal Transduction;Signaling Molecule;Site;Stimulus;Surface;Synapses;System;Technology;Time;Tissues;transmission process;Travel;Work

PROJECT_TITLE: Genetic analysis of innate immunity using C. elegans

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Stem cell lineage commitment in response to external stimuli including biomaterial structure and stiffness may provide an alterantive approach to regenerate complex tissues. Our biomaterial proposal aims to design and integrate these features in the scaffold design for complex tissue regeneration. We will employ this scaffold platform technology to study osteochondaral tissue with an interface to promote its integration with host tissue.

PI_NAMEs: NUKAVARAPU, SYAM  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;adult stem cell;Allografting;analytical tool;Architecture;Arthroscopy;Autologous Transplantation;Beds;Biocompatible Materials;Biomedical Engineering;Biophysics;blebbistatin;bone;Bone Regeneration;Cartilage;Cell Communication;Cell Lineage;Cells;Chemistry;Clinical;Complex;Cues;Defect;design;Development;Elasticity;engineered stem cells;Engineering;Failure;Fibrocartilages;Gene Expression;Goals;Growth Factor;healing;Histologic;Histology;Image Analysis;Immunohistochemistry;Immunologics;Implant;implantation;In Vitro;in vivo;innovation;interfacial;Knee;Knowledge;Lead;Length;Literature;Maps;Measures;mechanical signal;Mechanics;Mediating;Mesenchymal Stem Cells;Methodology;Microfabrication;Modeling;Modulus;Myosin Type II;Natural regeneration;non-muscle myosin;novel;Oryctolagus cuniculus;osteochondral repair;osteochondral tissue;osteogenic;Outcome;Phase;Polymers;Porosity;Procedures;Property;protein expression;Publications;receptor;regenerative approach;repaired;response;Role;Sampling;scaffold;sex;standard care;stem cell differentiation;stem cell fate;stem cells;Stimulus;Structure;Surface;System;Technology;technology platform;Testing;Tissue Engineering;tissue regeneration;tissue repair;Tissues;tool;unpublished works;Vascular blood supply;Work

PROJECT_TITLE: Biodegradable Matrices with Structural and Physical Cues for Interface Engineering

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Cancer

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The Cancer Research Experience for Undergraduates (CREU) program will provide short term, immersive experiences in cancer research to qualified undergraduates. This research-intensive experience will be coupled with weekly seminars that explore fundamental questions in cancer biology, research techniques, and professional development, including career mentoring.

PI_NAMEs: SCHWEPPE, REBECCA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Admission activity;anti-cancer research;Area;Bioinformatics;Biomedical Research;Biotechnology;Cancer Biology;career;Clinic;Clinical;Clinical Oncology;clinical translation;Colorado;Coupled;design;Development;Educational workshop;Enrollment;Evaluation;Event;experience;Exposure to;Faculty;Future;Goals;Immersion;innovative technologies;Institution;interest;Investigational Therapies;Laboratories;laboratory experience;Learning;Link;Malignant Neoplasms;Measures;meetings;Mentors;Minority Recruitment;Minority-Serving Institution;molecular diagnostics;New Mexico;personalized medicine;Postdoctoral Fellow;pre-doctoral;programs;Qualifying;Recording of previous events;recruit;Recruitment Activity;Research;Research Technics;Science;Scientist;Structure;Students;success;summer research;The University of Colorado Cancer Center;tool;Training;training opportunity;Translating;translational cancer research;translational potential;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;university student

PROJECT_TITLE: Cancer Research Experiences for Undergraduates (CREU)


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Hematology;Lung;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE Chronic lung dysfunction (CLD) is a major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT), with the diagnosis often not established until a significant decline in lung function exists. The ability to diagnose CLD early in its clinical course, prior to the development of irreversible lung disease is an unmet need, especially in young children in which diagnostic pulmonary function tests (PFT) are often difficult to perform. We have now designed a multi-center trial to evaluate a novel CT-based analytical technique (parametric response mapping) as a predictor of CLD in adult and pediatric HCT recipients.

PI_NAMEs: GALBAN, CRAIG J;YANIK, GREGORY A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Adult;Age;Airway Disease;Allogenic;Biological Markers;Bone Marrow Transplantation;Bronchiolitis Obliterans;cell injury;Cessation of life;Child;Childhood;Chronic;chronic graft versus host disease;Chronic Lung Injury;Chronic Obstructive Pulmonary Disease;Clinical;clinical development;Complication;Data;data repository;design;Detection;Development;Diagnosis;Diagnostic;diagnostic value;Disease;Disease Progression;disorder subtype;Dyspnea;Early Diagnosis;functional decline;Functional disorder;Hematopoietic Stem Cell Transplantation;High Resolution Computed Tomography;high risk;Image;improved;Intervention;learning strategy;Lung;lung allograft;lung development;Lung Diseases;lung injury;Machine Learning;machine learning model;Maps;Measurement;Measures;Medicine;Methodology;Michigan;Modeling;Morbidity - disease rate;mortality;Multicenter Trials;novel;Observational Study;Outcome;Patient Care;patient stratification;Patients;pediatric patients;Phase;pneumonitis and fibrosis;Population;post-transplant;precision medicine;prevent;primary endpoint;prospective;Prospective Studies;pulmonary function;pulmonary function decline;Pulmonary function tests;Pulmonary Pathology;Quality of life;recurrent infection;Reporting;Research Personnel;response;Risk;Scanning;Serology;Serum;small airways disease;Structure of parenchyma of lung;Survival Rate;Syndrome;Techniques;Technology;Testing;Time;Training;Transplant Recipients;Transplantation;United States National Institutes of Health;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Although diminished breathing capacity and airway defense undermine the quality and duration of life in virtually all neuromuscular disorders, such as spinal injury, ALS, Pompe disease, muscular dystrophy and Parkinson’s disease, few biomedical researchers have the expertise and translational perspective needed to develop new treatments that preserve or restore the ability to breathe and defend the airway. This renewal application seeks continued funding to train pre- and postdoctoral fellows with basic science, clinical or engineering backgrounds to fill this critical need. Trainees from diverse scientific backgrounds will develop a solid foundation in the respiratory biology, airway defense, translational research and technical/analytical skills needed for productive careers in breathing research and therapeutics.

PI_NAMEs: MITCHELL, GORDON S. (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Breathing;Research;Therapeutic

PROJECT_TITLE: Breathing Research and Therapeutics (BREATHE)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE This project will establish a clinical trial-on-a-chip for testing novel therapies for dystrophin deficient muscular dystrophy (Duchenne or Becker). Cardiac and skeletal engineered muscle tissues from human induced pluripotent stem cells are tested and the efficacy of a novel inhibitor of the cation channel -TRPC6 assessed. Blocking TRPC6 in mice with severe DMD shows promise for improving heart and skeletal muscle function, and the new assay system should provide a high-throughput method to screen efficacy among different patients, test drug safety, and optimize clinical trial design.

PI_NAMEs: KASS, DAVID ALAN;KIM, DEOK-HO  (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: 3-Dimensional;Animal Model;antagonist;Architecture;base;Becker Muscular Dystrophy;Behavior;Benchmarking;Biological Assay;Biological Availability;Biological Markers;Cardiac;Cardiac Myocytes;Cations;Cell Communication;Cell Shape;Cells;Child;chromatin immunoprecipitation;Clinical;Clinical Engineering;clinical phenotype;clinical trial on a chip;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Data;Data Set;design;Development;Disease;disease heterogeneity;disease phenotype;Disease stratification;Dose;drug testing;Duchenne muscular dystrophy;dystrophic cardiomyopathy;Dystrophin;effectiveness evaluation;efficacy evaluation;efficacy testing;Electrophysiology (science);Engineering;Extracellular Matrix;flexibility;Functional disorder;Gene Deletion;Genes;Genetic Diseases;Genetic Heterogeneity;Genotype;Goals;Heart failure;Heterogeneity;high throughput analysis;high throughput screening;Histology;Human;human induced pluripotent stem cells;human tissue;Image;imaging capabilities;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inhibitor;Ion Channel;kidney fibrosis;Link;Magnetism;male;mdx mouse;Mechanics;medication safety;Methods;microphysiology system;Modeling;Modification;Molecular;molecular marker;mortality;mouse model;Mus;Muscle;muscle engineering;Muscle function;Muscular Dystrophies;mutant;Mutation;Myocardium;Myopathy;Normal Cell;novel;novel therapeutics;Optics;Oral;Outcome;Output;patient population;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 1 study;Phenotype;Physiological;Play;Population;Positioning Attribute;pre-clinical;pressure;Proteins;Protocols documentation;receptor;Recovery;Reporting;response;Role;Running;Safety;safety testing;screening;sensor;Severity of illness;Silicones;skeletal;Skeletal Muscle;skeletal muscle weakness;Skeletal Myoblasts;skeletal tissue;Stress;Striated Muscles;System;Techniques;Testing;Therapeutic;Therapeutic Studies;Time;Tissue Engineering;Tissue Model;Tissues;Toxic effect;Treatment Efficacy;TRP channel;Utrophin;Validation

PROJECT_TITLE: Engineering Clinical Trials on a Chip for Dystrophin-Deficient Muscular Dystrophy


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: NEUROSCIENCES

PHR: Close to 500,000 Americans have dystonia, representing the third most common movement disorder after Parkinson’s disease and tremor. We will use molecular genetics, electrophysiology, and behavior analysis to determine protein function in specific cells and to gain a basic understanding of how cell-specific changes lead to dystonia-related motor deficits.

PI_NAMEs: LI, YUQING  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;Affect;American;Amino Acids;Animal Model;Antisense Oligonucleotides;Artificial Intelligence;autosome;Behavior;Behavioral;Binding;Biochemical;Brain;brain cell;Brain region;cell type;Cells;Characteristics;cholinergic;cholinergic neuron;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Corpus striatum structure;Development;disabled;Disease;Dopamine;Dopamine Receptor;dopaminergic neuron;DRD2 gene;Dystonia;DYT1 gene;early onset;Early Onset Dystonia;effective therapy;Electrophysiology (science);Endoplasmic Reticulum;Environment;Exons;Family;Functional disorder;Funding;GAG Gene;gain of function;Genes;Genetic;Glutamates;Goals;Impairment;in vivo;Individual;interdisciplinary approach;Interneurons;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Lead;Limb structure;Machine Learning;Metabolism;Modeling;Molecular Chaperones;Molecular Genetics;motor deficit;mouse model;Movement;Movement Disorders;Mus;Muscle Contraction;network models;neurochemistry;Neuronal Dysfunction;Neurons;Newborn Infant;novel;Nuclear Envelope;Nucleotides;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Penetrance;Phenotype;Play;Posture;protein folding;protein function;Proteins;Research;Research Personnel;Role;small hairpin RNA;Source;Symptoms;System;targeted treatment;Techniques;Testing;therapeutically effective;TOR1A gene;TorsinA;Tremor;United States National Institutes of Health;Wheelchairs;Work

PROJECT_TITLE: Pathophysiology of DYT1 dystonia: Targeted Mouse Models

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: SAN JOSE

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN JOSE STATE UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: The spontaneous formation of amyloid fibrils has been implicated in a variety of diseases, including Alzheimer’s disease and type 2 diabetes, yet the mechanism by which amyloid fibril formation is initiated via primary nucleation, an active area of research for the development of preventative treatments for amyloid diseases, is largely unknown. This proposal seeks to infer mechanisms for primary nucleation via a novel coarse-grained computer model of protein aggregation that can reproduce both experimentally determined fibrillar topologies and patterns of spatial propagation of fibril formation. This work will both contribute to an improved understanding of the mechanism of primary nucleation, as well as technological innovations to computational network models for studying molecular self-assembly.

PI_NAMEs: GRAZIOLI, GIANMARC  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Alzheimer's Disease;amyloid fibril formation;Amyloid Fibrils;amyloid structure;Amyloidosis;Area;Binding;Biological;Biological Products;Biomimetic Materials;computational network modeling;Computer Models;Computer Simulation;computerized tools;Coupled;Dependence;design;Development;Disease;drug development;Dyes;Environment;Etiology;Exhibits;experimental study;Family;Fluorescence;Fluorescence Microscopy;Freedom;Future;Grain;Graph;Growth;human disease;improved;Individual;innovation;Insulin;insulin granule;Kinetics;Length;Liquid substance;Measures;meter;Methodology;Methods;Microfluidics;Microtubules;Mission;Modeling;molecular assembly/self assembly;Molecular Structure;monomer;Motion;National Institute of General Medical Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nuclear Magnetic Resonance;Onset of illness;particle;Pattern;Pharmaceutical Preparations;Phase;Polymers;Predisposition;pressure;Preventive treatment;Prion Diseases;Process;protein aggregation;protein data bank;Proteins;Reaction;Reporting;Research;research and development;self assembly;simulation;Site;Solvents;Space Models;Structure;Structure of beta Cell of islet;Study models;System;Techniques;technological innovation;Testing;Time;time use;Travel;United States National Institutes of Health;Validation;Work;X-Ray Crystallography

PROJECT_TITLE: Probing Amyloid Fibril Self-Assembly with Network Hamiltonian Simulations in Explicit Space


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative  Contraction of skeletal muscle is a highly regulated process, which involves the sliding of thin actin filaments past thick myosin filaments. When this process is compromised, skeletal myopathies arise with symptoms that vary from mild to severe, and phenotypes that range from muscle weakness and debilitation to death. Myosin binding protein-C (MyBP-C) comprises a family of important regulators of muscle contractility, and is expressed in both skeletal and cardiac muscles. Consistent with this, mutations in the genes encoding the cardiac and slow skeletal isoforms have been causally linked with the development of hypertrophic cardiomyopathy and distal arthrogryposis, respectively. Our studies will focus on the involvement of the slow skeletal MyBP-C isoform in a new form of myopathy accompanied by muscle weakness, hypotonia, body deformities and tremor. Our overarching goal is to understand the molecular etiologies underlying this myopathy and the origin of the tremor phenotype. The obtained information will be highly novel and impactful in the long term for disease diagnosis and effective therapeutic design.

PI_NAMEs: KONTROGIANNI-KONSTANTOPOULOS, AIKATERINI  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Actins;Actomyosin;Adult;Affect;Alternative Splicing;Animal Model;Animals;Architecture;Arthrogryposis;Atomic Force Microscopy;ATP phosphohydrolase;Behavioral;Behavioral Assay;behavioral study;Benchmarking;Binding;Biochemical;Biological Assay;Biology;biophysical properties;Birth;Cardiac;Cessation of life;Circular Dichroism;Clinical Research;comparative;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Deformity;design;Development;Disease;disease diagnosis;Distal;effective therapy;Electrostatics;Etiology;Evaluation;Exhibits;experimental study;Face;Family;Fiber;Filament;Frequencies;Gender;Genes;Goals;Heart Diseases;Heterozygote;Hypertrophic Cardiomyopathy;Impairment;In Vitro;in vitro activity;in vivo;Individual;Knock-in;Knock-in Mouse;Life;Light;Link;Maintenance;Measurement;mechanical properties;Mediating;Microfilaments;Missense Mutation;Modeling;Molecular;molecular dynamics;molecular modeling;Morphology;Motility;mouse model;Movement;Mus;Muscle;Muscle hypotonia;Muscle Tremors;Muscle Weakness;mutant;Mutation;Myocardium;Myopathy;Myosin ATPase;myosin-binding protein C;N-terminal;novel;Pacemakers;Pathogenesis;Patients;Performance;Phenotype;Phosphorylation;Pilot Projects;postnatal;postnatal development;Posture;Pre-Clinical Model;Prevalence;Process;Production;Protein Isoforms;Proteins;reduced muscle strength;Regulation;Rest;RNA Splicing;Role;Science;segregation;skeletal;Skeletal Muscle;Slide;Striated Muscles;Structure;Symptoms;Testing;therapeutically effective;therapy design;Thick;Thick Filament;Thin Filament;Thinness;Tremor;Variant

PROJECT_TITLE: Novel MYBPC1 mutations cosegregate with a myopathy associated with muscle weakness, hypotonia and tremor


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Public Health Relevance: Schizophrenia is a debilitating illness that results in life-long limitations in psychosocial functioning, significant caregiver burden, and over $150 billion a year in economic costs. This proposal will use methods from network science, cognitive neuroscience, and neuroimaging to characterize thalamocortical circuit dysfunction in schizophrenia. Understanding the neural basis of schizophrenia is essential to developing new treatments for the disorder.

PI_NAMEs: WOODWARD, NEIL D. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anatomy;Animals;Anterior;Area;attentional control;Behavioral;Brain;Caregiver Burden;Cell Nucleus;Characteristics;Cognition;Cognitive;cognitive development;cognitive neuroscience;Data;Data Set;Disease;Doctor of Philosophy;economic cost;Electrophysiology (science);experience;Faculty;flexibility;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Geniculate body structure;graduate student;Human;human imaging;Image;imaging modality;Impaired cognition;Impairment;improved;in vivo;Individual;Knowledge;Lateral;Lesion;Link;Magnetic Resonance Imaging;Medial Dorsal Nucleus;Medical;Medical Students;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Modeling;MRI Scans;network models;neural;neuroimaging;Neuropsychology;Neurosciences;novel;Outcome;Pathology;Patient Education;patient oriented research;Phenotype;Postdoctoral Fellow;Prefrontal Cortex;Process;programs;Property;Psychopathology;Psychoses;psychosocial;Psychotic Disorders;public health relevance;Pulvinar structure;Research;Schizophrenia;Science;skills;Structural defect;Structure;Structure/Function Nuclei;support network;Testing;Thalamic Nuclei;Thalamic structure;Time;Training;Translating;Visualization;white matter;Work

PROJECT_TITLE: Research and mentoring on cognitive neuroscience and high-field MRI of the thalamus in schizophrenia


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Underage drinking is a serious public health problem because alcohol is the most widely used substance of abuse among adolescents and it has been associated with a range of health related risks such as drunk driving, unprotected sexual activity, school dropout, injuries, homicide, suicide, and lost productivity. Latino middle adolescents (age 14-16), in particular, experience health disparities related to alcohol use/related risks that represent major costs to society. Thus, preventing alcohol use/related risks among Latino youth via culturally and developmentally appropriate family-based preventive interventions is critically important and makes the proposed research relevant to NIAAA's strategic plan to develop and evaluate developmentally and culturally appropriate, preventive interventions for specified minority populations.

PI_NAMEs: LORENZO-BLANCO, ELMA I (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: acceptability and feasibility;Acculturation;Adolescence;Adolescent;adolescent substance use;African American;Age;Alcohol consumption;alcohol risk;alcohol use initiation;Alcoholism;Alcohols;Attitude;Automobile Driving;Award;Black Populations;Black race;career development;Child Rearing;clinical training;community engagement;Conflict (Psychology);coping;Coping Skills;cost;Data;design;deter alcohol use;Development;Discrimination;Disparity;drinking;Drug usage;Drunk driving;Educational Curriculum;efficacy evaluation;Emotional;empowerment;Evaluation;evidence base;experience;experimental group;Face;Family;Feasibility Studies;Feedback;Focus Groups;Goals;Health;health disparity;High Prevalence;high risk population;Homicide;improved;Injury;Intervention;intervention refinement;Intervention Studies;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Learning;Life;Link;Manuals;Mediating;meetings;Mentored Research Scientist Development Award;Mentors;Methods;Minority Groups;National Institute on Alcohol Abuse and Alcoholism;Outcome;Parent-Child Relations;Parents;Phase;pilot test;Prejudice;prevent;Prevention;Prevention program;Prevention Research;preventive intervention;Productivity;programs;protective effect;Public Health;Publications;Publishing;Qualitative Methods;racism;randomized trial;Reaction;Reporting;Research;Research Activity;Research Personnel;Risk;School Drop-Outs;Schools;Science;Scientist;Sex Behavior;skills;social norm;Societies;Spanish/English;Specific qualifier value;Strategic Planning;Stress and Coping;stressor;Student Dropouts;Substance of Abuse;substance use;Suicide;Surgeon;symposium;Theoretical model;therapy development;Training;Training Programs;Treatment Efficacy;underage drinking;underage drinking reduction;Unsafe Sex;Work;Youth

PROJECT_TITLE: JUNTOS (TOGETHER): Development of a family-based Latino youth use preventive intervention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Heart Disease;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Recurrence rates after a single atrial fibrillation (AF) ablation procedure are in the range of 30%- 50% at 1-year and are associated with increased AF burden and healthcare utilization, with corresponding reductions in functional capacity and quality of life. We propose a randomized, double-blind, clinical trial to test the hypothesis that early intervention after AF ablation, based on insertable cardiac monitor (ICM) detection of subclinical (asymptomatic) AF recurrence, will result in improved outcomes compared with standard follow-up and therapy, consisting of treatment based upon the development of clinical AF recurrence.

PI_NAMEs: GOLDENBERG, ILAN  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Ablation;Activities of Daily Living;adjudication;Anti-Arrhythmia Agents;arm;Arrhythmia;Atrial Fibrillation;Blinded;Cardiac;Cardiac ablation;Cardiopulmonary;Clinical;clinical center;clinical development;Clinical Trials;Data;Data Coordinating Center;Detection;Double-Blind Method;Drug usage;Early Diagnosis;Early Intervention;Electric Countershock;Emergency department visit;Exclusion;Exercise Test;experience;follow-up;health care service utilization;Heart Atrium;Hospitalization;improved;improved outcome;individual response;Intervention;Maintenance;Measures;Medical;Medical center;mobile application;Monitor;novel;Office Visits;patient subsets;Patients;Percutaneous Catheter Ablation;personalized approach;Pharmaceutical Preparations;Physicians;Population;prevent;primary endpoint;Procedures;Protocols documentation;Pulmonary veins;Quality of life;Questionnaires;Randomized;Recommendation;Recurrence;Refractory;Schedule;Specific qualifier value;standard care;success;Symptoms;Testing;Translating;transmission process;treatment arm;Treatment Protocols;treatment strategy;Universities

PROJECT_TITLE: Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation (ICM-REDUCE-AF Trial)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: CLARKSVILLE

ORG_NAME: NEURONASCENT, INC.

PHR: Neuronascent, Inc PI: Kelleher-Andersson, J, PhD Project Narrative Results from the proposed non-clinical, long-term safety studies of NNI-362 in dogs and rats and the further scale-up of GMP material that is formulated into chewable gel caps will allow for the ongoing clinical development of Phase 2 proof-of-concept trial in mild to moderate Alzheimer’s patients. As proposed in the Specific Aims, long-term administration of NNI-362 (6-months) in male and female rats and dogs is required in order to treat humans for the same length of time, which should be sufficient to observe neuron regeneration in aged Alzheimer’s patients. The completion of Phase1a placebo-controlled trial of NNI-362, appears to demonstrate safety and potential efficacy by reversing an early brain-specific AD progression biomarker (i.e., phosphoTau181) and Neuronascent further hypothesizes that the longer-term administration of NNI-362 over a six-month period will promote neuron regeneration resulting in the reversal of cognitive impairment and functional deficits in mild to moderate AD patients.

PI_NAMEs: KELLEHER-ANDERSSON, JUDITH A (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acute;Adult;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;animal safety;Animals;aqueous;arm;Behavioral;Brain;Canis familiaris;capsule;Chronic;Clinical;clinical development;Cognitive;Contractor;Cyclic GMP;Disease;disease model;Doctor of Philosophy;Dose;Drug Compounding;Drug Kinetics;Encapsulated;Ensure;experience;Failure;Fasting;FDA approved;Female;follow-up;Food;Formulation;Gel;Generations;Goals;Grant;Hippocampus;Human;Impaired cognition;Intervention;Kilogram;Length;Lipids;Liquid substance;male;manufacture;Measures;meetings;Methods;Neurologist;neuron regeneration;Neurons;neuroprotection;Neuroprotective Agents;Oral;Pathology;patient population;patient stratification;Patients;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;phase II trial;placebo controlled trial;Placebos;Plasma;preclinical study;Preparation;primary endpoint;progression marker;Rattus;regenerative therapy;Reporting;Ribosomal Protein S6 Kinase;Safety;safety study;safety testing;scale up;Site;Testing;Time;Toxic effect;Toxicokinetics;Translations;treatment duration;trial planning;Update;Work

PROJECT_TITLE: Completion of Non-clinical long-term GLP safety and GMP manufacture for first-in-class neuron regenerative therapy, NNI-362 Phase 2 POC AD trial


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Public Health Relevance: Atrial fibrillation (AF) occurs in 30-50% of patients undergoing cardiac surgery and is associated with prolonged hospital stay, hemodynamic instability, increased risk of stroke, and increased mortality. I observe significant associations between epicardial adipose tissue, inflammation and AF. This study will explore the molecular mechanisms underlying these associations to identify new targets for the development of effective treatment for postoperative AF.

PI_NAMEs: TRAN, KHANH-VAN THI (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Anti-Inflammatory Agents;Atrial Fibrillation;Award;Bioinformatics;Biometry;Biopsy Specimen;Blood specimen;Cardiac Myocytes;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular system;career;Cell Density;Cell Lineage;Cells;chemokine;clinical investigation;Clinical Research;clinical training;clinical translation;Clinical Trials;Coronary Artery Bypass;CXCL10 gene;CXCL14 gene;cytokine;Data;Dendritic Cells;Development;Dexamethasone;Disease;Double-Blind Method;Echocardiography;effective therapy;electrical property;Electrophysiology (science);Enrollment;experience;Fatty acid glycerol esters;Foundations;Funding;Goals;Heart Atrium;heart rhythm;hemodynamics;Histologic;IL18 gene;Immune;indexing;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Integral Membrane Protein;ITGAX gene;K-Series Research Career Programs;Left;Left Atrial Function;Left atrial structure;Length of Stay;Macrophage;Measures;Mechanics;Mediating;Medicine;Mentors;Molecular;monocyte;mortality;Myeloid Cells;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Natural Immunity;neutrophil;Non-Steroidal Anti-Inflammatory Agents;novel;Operative Surgical Procedures;Participant;patient oriented;Patient-Focused Outcomes;Patients;Physicians;Physiology;Plasma;Play;Postoperative Period;Prevalence;Prevention;Prevention therapy;Process;prospective;Proteomics;public health relevance;Randomized;recruit;Recurrence;Research;Research Design;Research Methodology;Role;Scientist;Severities;Signal Pathway;skills;Steroids;stroke risk;Testing;Training;transcriptomic profiling;transcriptomics;Translational Research;translational scientist;Work

PROJECT_TITLE: The Role of Highly inflamed Epicardial Adipose Tissue in the Development of Atrial Fibrillation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: The main goal is to establish a firm theoretical link between genetic diversity and various physical and biological processes that underpin spatial growth. The successful accomplishment of this goal will enable meaningful interpretation of genetic data and suggest rational intervention strategies to control evolutionary outcomes, e.g., the emergence of drug resistance.

PI_NAMEs: KOROLEV, KIRILL SERGEEVICH (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Affect;analytical method;Antibiotic Resistance;Behavior;Biological Process;Biology;biophysical model;Biophysical Process;Biophysics;Chemicals;Chemistry;climate change;cost;Cues;Data;density;Dependence;Diffusion;Disease Vectors;Drug resistance;Endowment;Epidemic;Evolution;experience;falls;fighting;Genealogical Tree;Genealogy;Genetic;Genetic Processes;Genetic Programming;Genetic Variation;Goals;Growth;Heterogeneity;Individual;Infection;innovation;interest;Intervention;Joints;Learning;Letters;Link;Malignant Neoplasms;Mammalian Cell;Mathematics;mechanical drive;mechanical force;mechanical pressure;Medicine;Methods;Microbe;Microbial Biofilms;microbial colonization;microbiome;Minor;Modeling;Morphology;Movement;Mutation;neglect;Nutrient;Outcome;Pattern;physical process;Population;Population Density;Population Dynamics;Population Genetics;Population Growth;Population Heterogeneity;Population Process;Population Size and Growth;Process;Reaction;Research;response;Sampling;Science;Shapes;simulation;spatiotemporal;Stationary Populations;Structure;Technology;Testing;Theoretical model;theories;tool;tumor;Visit;Work

PROJECT_TITLE: Relationship between genealogies and biophysical processes during spatial growth.

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Growth restriction is associated with infant and adult cardiovascular, metabolic, and kidney disorders, mechanisms of which are not fully resolved. The current project will investigate a novel concept that peripheral sympathoexcitation triggered by UII contributes to organ injury in growth-restricted newborns. The mechanisms identified in this proposal may provide novel therapeutic targets to reduce the burden of infant and adult renal and cardiovascular morbidity and mortality.

PI_NAMEs: ADEBIYI, ADEBOWALE  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Anabolism;Animals;Attenuated;Birth;Birth Weight;Cardiovascular Diseases;Cardiovascular system;Catecholamines;Cells;Chronic Kidney Failure;Data;Denervation;early onset;End stage renal failure;Exhibits;Exocytosis;Family suidae;fetal;Fetal Growth Retardation;Functional disorder;Generations;Glomerulonephritis;Growth;Heart Diseases;hemodynamics;high risk;Homeostasis;Human;Hypertension;hypoperfusion;Impaired Renal Function;Infant;Injury to Kidney;innovation;Ischemia;Kidney;Kidney Diseases;Kidney Failure;late life;Life;Link;Low Birth Weight Infant;Metabolic Diseases;Microcirculation;Modeling;Molecular;Morbidity - disease rate;mortality;NADPH Oxidase;Neonatal;Neonatal Intensive Care;neonate;Nephrotic Syndrome;Nerve;Neurons;neurotransmission;new therapeutic target;Newborn Infant;Norepinephrine;novel;Organ;organ injury;Oxidative Stress;Peptides;Perfusion;Perinatal;Peripheral;pharmacologic;Phosphorylation;Physiological;Plasma;porcine model;pre-clinical;Pre-Clinical Model;Premature Birth;pressure;Procedures;Production;Reactive Oxygen Species;receptor;Regulation;Renal function;renal ischemia;Reperfusion Therapy;Risk;Sepsis;Signal Transduction;Small for Gestational Age Infant;System;Testing;tool;Translational Research;Tyrosine 3-Monooxygenase;urotensin II;vasoconstriction;Venous

PROJECT_TITLE: Urotensin II and renal insufficiency in growth-restricted infants.

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The consequences of early childhood obesity disparities are lifelong, with substantial cardiovascular risk to racial/ethnic and socioeconomic minority groups. This study integrates longitudinal geospatial, chemical, and psychosocial data to investigate how limited geospatial food access in pregnancy may increase oxidative stress and childhood obesity risk through mechanisms that involve chemical and psychosocial stressors. Understanding the currently unknown role of geospatial food access in driving oxidant stressors starting in utero would inform built environment investments and neighborhood strategies to decrease obesity disparities across the life course.

PI_NAMEs: DUH-LEONG, CAROL  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Age;American Heart Association;Anxiety;Asian;Automobile Driving;Biological Markers;Biology;Birth;Birth Weight;Black race;built environment;cardiometabolism;cardiovascular risk factor;Cardiovascular system;career development;Chemical Exposure;Chemicals;Child;Child Health;Clinical;cohort;craving;Data;data integration;Data Set;Development;dietary excess;Dietary Practices;Disparity;early childhood;Educational process of instructing;Endocrine disruption;Environment;Environmental Epidemiology;Environmental Exposure;ethnic disparity;Ethnic Origin;Ethnic Population;Exposure to;fast food;Fatty acid glycerol esters;Food;Food Access;food environment;food insecurity;Food Packaging;Food Supply;gestational weight gain;Goals;Guidelines;Health Food;Healthy Eating;Hispanic;Home;Household;Human;in utero;indexing;Individual;infancy;Intake;Interruption;Investments;Joints;Knowledge;Life;Life Cycle Stages;Literature;longitudinal analysis;Measures;medical schools;Mentors;Mentorship;Metabolic;Methodology;Minority Groups;Modeling;Molecular Weight;mother nutrition;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;Neighborhoods;Obesity;obesity in children;obesity risk;Outcome;Oxidants;Oxidative Stress;Parents;Participant;Pathway interactions;patient oriented research;Persons;phthalates;Physiological;Positioning Attribute;postnatal;Pregnancy;pregnant;prenatal;Preparation;Process;programs;psychosocial;Psychosocial Stress;psychosocial stressors;Public Health;public health insurance;Race;racial disparity;racial population;rapid infant weight gain;rapid weight gain;Research;Research Personnel;Resources;Restaurants;Risk;Role;Savory;Site;skills;Skinfold Thickness;social;social influence;socioeconomic disparity;socioeconomics;Statistical Methods;Stress;stressor;Structure;Supermarket;Time;Training;United States National Institutes of Health;urinary;Weight;Work

PROJECT_TITLE: Geospatial food access as a driver of environmental oxidant stressors and early obesity


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE The Navajo Birth Cohort Study (NBCS) is the first large-scale, well characterized prospective cohort study to assess the relationships between environmental exposures, birth outcomes, and child development in a tribal population. Representation of the Navajo population in the National ECHO cohort will contribute significantly to the understanding of risks to Indigenous populations through comparison of exposures and outcomes with other Indigenous populations and minority populations across the ECHO cohort.

PI_NAMEs: LEWIS, JOHNNYE L;MACKENZIE, DEBRA  (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: Address;Affect;Agreement;Birth;Categories;Characteristics;Child;Child Development;Child Health;Clinical;cohort;Cohort Studies;Conceptions;Couples;COVID-19;COVID-19 impact;Data;Data Set;data sharing;Development;Diagnosis;Disease;Education;Elements;Ensure;Environment;Environmental Exposure;Evaluation;experience;Exposure to;Family;Fertility;Health;immunoregulation;Income;Indigenous;innovation;instrument;interest;Language;Language Development;Learning;Life;Life Experience;Long COVID;Measures;Metabolic syndrome;Metal exposure;Metals;Minority Groups;Modeling;Native Americans;Native-Born;Navajo;neurodevelopment;Nutrient;Nutritional;offspring;Outcome;Outcome Measure;pandemic disease;Parents;Participant;participant enrollment;Patient Recruitments;Population;Population Study;predictive modeling;Pregnancy;programs;Prospective, cohort study;Protocols documentation;Recontacts;recruit;Reporting;Research;resilience;response;Risk;rurality;SARS-CoV-2 infection;Screening procedure;social communication;social determinants;sociodemographics;Source;Specific qualifier value;Time;toxicant;Tribal group;Update;Validity and Reliability

PROJECT_TITLE: Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]