ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Spinal cord injury is a severely debilitating event that profoundly impacts quality of life, yet there are limited effective treatment options for the patient beyond rehabilitation. The proposed research will determine how removal of the adhesion receptor, L-selectin, affects the behavior of the most abundant immune cell type (neutrophils) in the acutely injured spinal cord and subsequent long-term recovery. This work will elucidate the role of neutrophils in acute tissue damage, determine how L-selectin regulates neutrophil behavior, and advance a novel therapeutic strategy that enhances L-selectin removal from the surface of neutrophils.

PI_NAMEs: MCCREEDY, DYLAN A. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;adhesion receptor;Adhesions;Affect;Antibodies;Attenuated;Behavior;Binding;Blood;cell type;Cells;central nervous system injury;Chemosensitization;Clinical;clinically relevant;Contusions;cytotoxic;Diclofenac;Disease;effective therapy;Environment;Event;Excision;Exposure to;FDA approved;Goals;Hour;Human;Immune;improved;In Vitro;in vitro activity;in vivo;Individual;Infection;Inflammation;Inflammatory;Injury;intraperitoneal;Intravenous;intravenous administration;intravenous injection;Invaded;Knock-in Mouse;L Forms;L-Selectin;Ligand Binding;Ligands;long term recovery;Mediating;Mediator;Modeling;Mus;Myelin;Neurologic Deficit;Neurological outcome;neurological recovery;neuroprotection;neutrophil;Neutrophil Activation;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel therapeutic intervention;Pathogenicity;Patients;Phase;Play;Process;Production;Quality of life;Reactive Oxygen Species;receptor;Receptor Signaling;Recovery;Recovery of Function;recruit;Recruitment Activity;Rehabilitation therapy;Research;response;response to injury;Role;Spinal Cord;Spinal cord injury;spinal cord white matter;Surface;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;white matter;Work

PROJECT_TITLE: L-selectin shedding as a novel therapeutic strategy to mitigate acute secondary damage after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE The Center for Transformative Community-driven Research to Prevent Obesity-related Cancer (the Center) seeks to reduce cancer risk, and ultimately improve cancer outcomes for communities experiencing persistent poverty. The Center will include five cores: Administrative, Research and Methods, Career Enhancement, Developmental and Engagement Core. The Center will test interventions in the context of MD Anderson’s current place-based cancer prevention initiative (Be Well Communities™), around two scientific themes: 1) understanding social and environmental context of poverty (e.g., food insecurity, limited recreational infrastructure, few health promotion services) and 2) promoting health behavior changes of diet and physical activity as major contributing causes of obesity.

PI_NAMEs: BASEN-ENGQUIST, KAREN M (contact);MCNEILL, LORNA H.;RECHIS, RUTH

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Adult;Area;Automobile Driving;Behavior;behavior change;Behavioral Sciences;Black race;Body mass index;Breast;Cancer Center;Cancer Control;Cancer Control Research;cancer prevention;cancer risk;Cancer Survivor;cancer type;career;Child;Collaborations;Colorectal;Communities;community collaboration;community engaged approach;community engagement;community organizations;County;Development;Diet;Dietary Fiber;Dietary Intervention;Eating;Economics;Effectiveness;elementary school;Endometrial;Environment;Esophagus;Evidence based intervention;exercise intervention;experience;Face;Faculty;Family;food insecurity;Fostering;fruits and vegetables;Gallbladder;Government Agencies;Health;Health behavior change;health communication;Health equity research;Health Personnel;Health Promotion;Healthy Eating;Home;implementation science;improved;Incubators;Individual;Infrastructure;innovation;Intervention;Investments;Kidney;Liver;Malignant Neoplasms;Meat;Medically Underserved Area;Metabolic;Methods;Modeling;Motivation;Neighborhoods;novel;Obesity;Obesity associated cancer;obesity prevention;obesity risk;Outcome;Ovarian;Pancreas;Parents;Persons;Physical activity;Physical Function;physical inactivity;Policy Maker;poor communities;Population;Postmenopause;Poverty;Poverty Areas;Preventable cancer cause;Primary Prevention;Process;programs;Prostate;Recreation;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk;Risk Factors;School-Age Population;Schools;Science;Services;social;Socioeconomic Status;Stomach;Students;survivorship;Testing;Texas;Underrepresented Populations;Workplace

PROJECT_TITLE: Center for Transformative Community-Driven Research to Prevent Obesity-related Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

PHR: The Administrative Core provides leadership, oversight and infrastructure to support all scientific, administrative, and financial activities of the Center for Transformative Community-driven Research to Prevent Obesity-related Cancer (the Center), including the two research projects and the research and methods, career enhancement, developmental, and engagement cores. The Administrative Core will serve as the strategic hub of the Center, facilitating communication and collaboration among the community organizations and academic partners, as well as with members of the Persistent Poverty Initiative Network.

PI_NAMEs: BASEN-ENGQUIST, KAREN M (contact)

PROJECT_TERMS: Address;Applications Grants;Basen;Black race;Cancer Control;cancer health disparity;cancer prevention;career;career development;Collaborations;Communication;Communities;community academic partnership;community advisory board;Community Networks;community organizations;Community Outreach;community partners;community partnership;Complex;Development;Documentation;Ensure;Evaluation;Evaluation Methodology;Financial Activity;Fostering;Foundations;Funding;Future;Goals;Health;Home;improved;Infrastructure;insight;Institution;Joints;Lead;Leadership;Measures;meetings;member;Obesity;Obesity associated cancer;obesity prevention;Occupational activity of managing finances;operation;organizational structure;outreach;poor communities;Poverty;Poverty Areas;Process;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;social determinants;success;Training;United States National Institutes of Health;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Obesity;Prevention;Social Determinants of Health

PHR: The Research and Methods Core within our proposed Center for Transformative Community-driven Research to Prevent Obesity-related Cancer (the Center) will serve as a comprehensive, multilateral research and evaluation resource to all core directors, project leaders, trainees engaged in the Career Enhancement Core, and awardees of the Developmental Core. Services will include hypothesis refinement, design of clinical and basic science experiments, data acquisition and management, development and application of innovative and state-of-the-art statistical methodology, biostatistical and geospatial analyses, data interpretation, and publication of results generated by the Center through abstracts, papers, and presentations.

PI_NAMEs: SHETE, SANJAY  (contact)

PROJECT_TERMS: Address;Adoption;archive data;Basic Science;Biometry;career;Censuses;Clinical Sciences;Common Data Element;Communities;computerized data processing;Data;data acquisition;Data Analyses;Data Analytics;Data Collection;data handling;data management;Data Set;design;Development;Emerging Technologies;Ensure;Ethics;Evaluation;experience;experimental study;Funding;innovation;innovative technologies;Intervention;Lateral;Lead;Logistics;Measures;member;Methodology;Obesity associated cancer;obesity prevention;Outcome Measure;Paper;Pilot Projects;poor communities;Population;Poverty;Process;Productivity;Program Evaluation;Publications;quality assurance;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Services;social;Statistical Data Interpretation;Students;success;Time;Training;Work

PROJECT_TITLE: Research and Methods Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HPV and/or Cervical Cancer Vaccines;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Vaginal Cancer;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative The human papillomavirus (HPV) therapeutic vaccine being developed is likely to become a first-line therapy for high-grade squamous intraepithelial lesions (precursors of cervical cancer). This is particularly important for women who wish to have children because the standard surgical treatments have the unintended side effect of doubling the incidence of preterm delivery. In addition, the vaccine is being tested for the ability to reduce recurrence rates of head and neck cancers, and it may be used to prevent or treat other cancers caused by HPV, including anal, penile, vaginal, and vulvar cancers.

PI_NAMEs: NAKAGAWA, MAYUMI  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adjuvant;Anus;arm;Biopsy;Cancer Etiology;cancer recurrence;Candida;cell motility;Cervical;Cervix Uteri;Child;Clinical;Clinical Trials;Common wart;Controlled Clinical Trials;cross immunity;cross reactivity;curative treatments;design;Disease;Dose;Double Effect;Double-Blind Method;Effectiveness;Effector Cell;efficacy evaluation;Eligibility Determination;Enrollment;Epitope spreading;Excision;Funding;Goals;gut microbiome;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hypersensitivity skin testing;Immune;Immune response;Immunologic Factors;Immunologic Stimulation;Immunotherapy;improved;Incidence;Infection;Interleukin-12;Investigation;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;manufacture;Mediating;men;microbiome;mucosal site;No Evidence of Disease;Nose;novel vaccines;Operative Surgical Procedures;Oral cavity;Oropharyngeal;Patients;penis;Pharyngeal structure;Phase;Phase I Clinical Trials;Phase I/II Clinical Trial;Phase II Clinical Trials;phase II trial;Placebo Control;Placebos;pregnant;Premature Birth;prevent;Preventive vaccine;Probability;Procedures;Proteins;Public Health;Randomized;reagent testing;recruit;Recurrence;response;Role;Safety;Salivary Glands;side effect;Site;Squamous intraepithelial lesion;synthetic peptide;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Th1 Cells;therapeutic HPV vaccine;therapeutic vaccine;treatment arm;Vaccination;Vaccine Adjuvant;Vaccine Clinical Trial;vaccine efficacy;vaccine response;Vaccines;Vagina;Viral Load result;Vulva;Woman;women's clinical trial;women's treatment;young woman

PROJECT_TITLE: Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses-Renewal

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

PHR: Physical activity has been shown to improve cancer survivors’ well-being and is associated with longer survival after cancer diagnosis. This project will test a program to help cancer survivors from Acres Homes increase their physical activity and access physical activity resources in their community. We will also identify how the survivors’ neighborhood environment affects their physical activity levels.

PROJECT_TERMS: active lifestyle;Acute;Address;Affect;Air;Anxiety;behavior change;Behavioral;Black race;cancer diagnosis;Cancer Intervention;cancer prevention;cancer recurrence;Cancer Survivor;Cardiovascular Diseases;Characteristics;Chronic Disease;cognitive skill;Colorectal Cancer;Communication;Communities;community intervention;Control Groups;Crime;Data;design;Diabetes Mellitus;disability;Educational process of instructing;Effectiveness;effectiveness evaluation;Enrollment;Environment;evidence base;Exercise;experience;Exposure to;Fatigue;Financial Hardship;fitness;Fostering;Goals;Green space;Guidelines;Health;health literacy;Health Promotion;Home;improved;Individual;Intervention;Leisures;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;medically underserved;Mental Depression;Minority;mortality;neighborhood safety;Neighborhoods;Obesity associated cancer;obesity prevention;Outcome;Outcome Measure;Participant;Patient Self-Report;perceived discrimination;Personal Satisfaction;Physical activity;Physical environment;Physical Function;poor communities;Poverty;Poverty Areas;Prevention education;primary outcome;Program Effectiveness;programs;psychological distress;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;remediation;Reporting;Research;Research Project Grants;Resources;Risk;secondary outcome;skills;social;social vulnerability;Survivors;Symptoms;Testing;Texas;Time;Waiting Lists;walkability;Walking

PROJECT_TITLE: Research Project #2


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Evidence indicates that environmental exposure to pyrethroids, such as deltamethrin, at no-observed-adverse- effect level (NOAEL), increases the risk of neurodevelopmental disorders in the general population. Through an interdisciplinary approach that includes state-of-the-art confocal and mass-spectrometry imaging, electrophysiology, behavioral studies and viral vector-based chemogenetic manipulation in rodent models of early-life exposure to deltamethrin, we will provide a mechanistic model of neurotoxicity of pyrethroids in the developing brain. These studies will provide novel insights to evaluate the risk of neurodevelopmental disorders in the context of environmental toxin exposure.

PI_NAMEs: GREEN, THOMAS ARTHUR;LAEZZA, FERNANDA  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Action Potentials;Affect;Agriculture;Animal Model;Anxiety;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;behavioral study;Brain;Brain region;brain tissue;Categories;cell type;Cells;Corpus striatum structure;course development;Cross Reactions;cross reactivity;decamethrin;designer receptors exclusively activated by designer drugs;Deterioration;Development;Dopamine;Early identification;early life exposure;Electrophysiology (science);endophenotype;Environmental Exposure;epidemiology study;Exposure to;Functional disorder;gamma-Aminobutyric Acid;Gas Chromatography;General Population;Genetic;genetic approach;genetic manipulation;Guidelines;Household;human disease;Hyperactivity;Immunohistochemistry;Impulsivity;in vivo;inhibitory neuron;Injections;Insecta;insight;interdisciplinary approach;Interneuron function;Interneurons;Lactation;Life;Mammals;Mass Fragmentography;mass spectrometric imaging;Methods;Modeling;Molecular;Motor Activity;mouse model;Mus;neural;Neurodevelopmental Disorder;neuronal excitability;Neurons;neuroregulation;neurotoxicity;neurotoxicology;Neurotoxins;No-Observed-Adverse-Effect Level;novel;Nucleus Accumbens;Outcome Study;Output;Parvalbumins;patch clamp;Pathway interactions;Pattern;Pesticides;Pregnancy;Preparation;Process;Property;Protein Isoforms;Proteins;pyrethroid;Reporting;response;Risk;Risk Factors;Rodent Model;Schools;SCN1A protein;Signal Transduction;Slice;Social Behavior;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Synapses;tandem mass spectrometry;Testing;therapeutic development;Toxic effect;Toxic Environmental Substances;United States Environmental Protection Agency;Viral Vector;voltage

PROJECT_TITLE: Neurotoxicology of deltamethrin in the developing brain

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Modulation of the pupil by light is important for regulating visual sensitivity and acuity, serves as a standard neurological test, and is increasingly used to gain insight into affective disorders, metabolic disorders, and neurodegenerative diseases. The pupillary light response appears simple but is multifaceted, with properties and underlying mechanisms that are enigmatic. We will address this gap in knowledge to provide a deeper understanding of how the nervous system produces motor output according to environmental cues, and to help improve the use of pupillary responses in clinical diagnoses.

PI_NAMEs: DO, MICHAEL TRI HOANG (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Action Potentials;Address;Affect;Afferent Neurons;Animals;Area;Arousal;awake;Biological;Biology;Biophysical Process;biophysical techniques;Biophysics;Brain;Cell Nucleus;cell type;Cells;circadian;clinical diagnosis;Collection;Cone;Cues;Dependence;Diagnosis;Diameter;Endowment;Engineering;experimental study;Goals;improved;in vivo;in vivo imaging;Individual;insight;Iris;Knockout Mice;Knowledge;Lead;Learning;Light;Light Cell;light intensity;Lighting;Measurement;Measures;Mediating;melanopsin;Metabolic Diseases;Methods;Miosis disorder;Molecular;Monitor;Mood Disorders;Motor;motor control;Motor output;multiphoton imaging;Mus;Muscle;Mydriasis;Nervous System;Neurodegenerative Disorders;Neurologic;Newly Diagnosed;operation;Optics;Organism;Output;Pathway interactions;Photons;Photoreceptors;Phototransduction;Presynaptic Terminals;Process;Property;Pupil;recruit;response;Retina;Retinal Cone;Retinal Ganglion Cells;Retinal Pigments;Rod;Sensory;sensory mechanism;Shapes;Signal Transduction;spatiotemporal;Synapses;System;Tectum Mesencephali;Testing;Time;Variant;Vertebrate Photoreceptors;Vision;Visual;Visual Acuity;Visual Pathways;visual stimulus;Visual System;Work

PROJECT_TITLE: Downstream Actions of Biophysical Mechanisms in the Visual System


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide;Suicide Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Nearly all adolescents use social media sites, yet for a vulnerable subset of teens, social media use may increase risk for suicide. Given rising suicide rates among adolescent girls in recent years, it is critical to examine the reasons why social media use may be related to suicidal thoughts and attempts. Findings of this study will have the potential to inform future suicide intervention and prevention efforts that address the unique needs of adolescents in the digital age.

PI_NAMEs: NESI, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Affect;Affective;Age;Area;Arousal;Attention;Behavioral Mechanisms;Benefits and Risks;career;career development;Clinical;Clinical Research;Cognitive;Data;Data Set;Databases;Development;digital;Discipline;Disease;Emotional;Ensure;Environment;Ethics;Exhibits;experience;Eye;Facebook;Feedback;Feeling suicidal;Female;Female Adolescents;follow-up;Fostering;Frequencies;Future;gaze;girls;Goals;Grant;Hospitals;Image;indexing;Individual;innovation;Instagram;interdisciplinary collaboration;Intervention;Interview;Laboratories;Length;Linguistics;Literature;Longitudinal Studies;Machine Learning;machine learning classifier;machine learning method;machine learning model;Measures;media use;Mental Health;Mentors;Metadata;Methods;Modeling;National Institute of Mental Health;Natural Language Processing;Participant;Patient Self-Report;peer;Persons;Phase;Physiological;Positioning Attribute;Predisposition;prevent;programs;prospective;Psychiatry;Recording of previous events;recruit;Research;Research Personnel;Resources;response;Rhode Island;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Self Disclosure;Series;Severities;Site;social;Social Environment;social media;social norm;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Techniques;Teenagers;Testing;therapy development;Time;Training;Translational Research;Twitter;Universities;visual tracking;web interface;Work;Youth

PROJECT_TITLE: Social Media Use and Mechanisms of Suicide Risk in Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Individuals who develop glaucoma before age 40 (early-onset glaucoma) have few treatment options and are most likely to become blind during their lifetimes. Only ten genes are known to cause this condition and these only account for 20% of cases leaving most patients without a molecular diagnosis. The overall goal of this proposal is to discover novel early-onset glaucoma causal genes that will provide opportunities for gene-based screening and diagnostic tests, allowing for improved risk prediction and genetic counseling, as well as new, and potentially curative, therapeutic targets.

PI_NAMEs: WIGGS, JANEY L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adult;Affect;Age;Alleles;ANGPT1 gene;Australia;autosome;blind;Blindness;causal variant;Cells;Child;Clinical;clinical care;Code;Collaborations;Collection;Complex;Copy Number Polymorphism;Data;Detection;Development;Diagnostic tests;Disease;disorder risk;early onset;Enhancers;Ensure;Etiology;Exhibits;exome sequencing;experience;Family;Family member;FOXC1 gene;Funding;gain of function;Gene Expression;Gene Frequency;gene therapy;Genes;Genetic Counseling;genetic element;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomics;Glaucoma;Goals;improved;Individual;insertion/deletion mutation;International;Knowledge;Length;loss of function;Methods;MicroRNAs;Modeling;Molecular Diagnosis;multi-ethnic;Mus;Mutation;Nature;novel;Oligogenic Traits;online resource;Onset of illness;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Pattern;polygenic risk score;Population;Primary Open Angle Glaucoma;proband;Process;Promoter Regions;Quality Control;rare variant;Regulation;risk prediction;risk variant;RNA Splicing;screening;segregation;Testing;therapeutic target;Untranslated RNA;Variant;web platform;whole genome;Work;young adult;Zebrafish

PROJECT_TITLE: Defining early-onset glaucomagenetic etiologies

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: The Acres Homes region in Houston, TX, is a predominantly African American and Hispanic community, a persistent poverty area with 69% of the residents living in food desert areas, and over 40% of the adult residents reportedly being obese. Ours is a cluster-randomized trial to assess the impact of Brighter Bites (BB), a school-based intervention improving access to fresh produce and nutrition education, on obesity and metabolic outcomes among children enrolled across 12 elementary schools serving the Acres Homes community and their parents. This project informs the translation and scaling efforts of BB, a highly successful natural experiment, and also advances dissemination and implementation science by studying and improving upon implementation strategies to increase program reach and impact in persistent poverty areas such as Acres Homes.

PI_NAMEs: SHARMA, SHREELA V (contact)

PROJECT_TERMS: Adult;African American;Area;Behavior;Behavior Therapy;Bite;Blood Pressure;Body mass index;cancer prevention;Carotenoids;Characteristics;Child;Cluster randomized trial;Communities;comparison control;comparison intervention;COVID-19 pandemic;Diet;dietary;Dietary intake;Dietary Intervention;dissemination science;Dose;Education;Effectiveness;elementary school;Enrollment;Environment;evidence base;Family;Financial Hardship;Fingers;follow-up;Food;Food Access;food desert;food environment;food insecurity;food security;fruits and vegetables;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;health literacy;Height;Hispanic Americans;hispanic community;Home;Home environment;Household;implementation science;implementation strategy;Improve Access;improved;innovation;Intake;Intervention;Low income;Measures;Mediating;Metabolic;mobile application;Natural experiment;Neighborhoods;nutrition;nutrition education;Nutritive Value;Obesity;Obesity associated cancer;obesity prevention;Outcome;Parents;Participant;perceived discrimination;post intervention;Poverty;Poverty Areas;Program Effectiveness;programs;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recipe;Reporting;Research;Research Project Grants;response;school health;Schools;secondary outcome;Skin;social;social health determinants;social vulnerability;Source;Taste Perception;Testing;Texas;Translations;Vegetables;volunteer;Waiting Lists;Weight

PROJECT_TITLE: Research Project #1


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: WILLISTON

ORG_NAME: MICROBRIGHTFIELD, LLC

ORG_STATE: VT

PHR: Narrative Accurate and rigorous analysis of all visible axonal fibers (with and without signs of acute axonal injury) in 2D and 3D microscopy images of central nervous system (CNS) tissue of non-transgenic and transgenic animal models as well as in human postmortem CNS tissue holds the promise of enabling novel insights into physiological neural network connectivity patterns as well as into the neuropathological underpinnings of alterations in connectivity associated with human neurodevelopmental, neuropsychiatric, neurodegenerative and neurological disorders. Our proposed product will be a transformative technology, using a number of technical innovations that, for the first time, will enable researchers to perform such studies automatically and in a comprehensive manner. This system will allow researchers to make new discoveries based on new studies that are currently not feasible, ultimately providing the basis for developing novel treatments to prevent and fight complex brain diseases.

PI_NAMEs: GLASER, JACOB R (contact)

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: 3-Dimensional;Acute;Address;Animal Model;Area;Attention;automated segmentation;Autopsy;Axon;axon injury;Biotechnology;Brain Diseases;brain tissue;Central Nervous System;Classification;cloud based;cluster computing;Collaborations;commercialization;Communities;Complex;Computer Assisted;Computer software;Computers;data format;deep neural network;density;Detection;Development;Fiber;fighting;Genes;Goals;High Performance Computing;Human;Image;image processing;imaging modality;improved;Individual;innovation;insight;Institution;interest;Investigation;Knowledge;Laboratories;Learning;Letters;Manuals;Measurement;Methods;microscopic imaging;National Institute of Mental Health;Nature;Nervous System Disorder;neural network;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuropathology;neuropsychiatric disorder;Neurosciences;Neurosciences Research;new technology;next generation;novel;open data;Optics;Pattern;Performance;pharmacologic;Phase;Physiological;Presynaptic Terminals;prevent;Production;prototype;reconstruction;Research;research and development;Research Personnel;Running;Societies;software as a service;Space Perception;Specific qualifier value;System;Technology;terabyte;Testing;Time;Tissues;tool;training data;Transgenic Animals;treatment strategy;two-dimensional;usability;Validation;web services;Work

PROJECT_TITLE: Next generation axonal quantification and classification using AI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pain Research;Rare Diseases;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE This Genotype-Phenotype project involves the largest known cohort of older adults with fragile X-associated tremor/ataxia syndrome (FXTAS), one of the leading single-gene forms of neurodegeneration. By following these individuals over time, we hope to understand the natural history of FXTAS in multiple clinical and molecular domains, with a focus on better understanding why females progress faster than males in pain and psychiatric domains but more slowly in the motor and neurocognitive domains.

PI_NAMEs: HAGERMAN, PAUL J;HAGERMAN, RANDI J. (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Alcohols;Alleles;Anxiety;Appearance;Ataxia;Atrophic;Autoimmune;Autoimmune Diseases;Cell Nucleus;CGG repeat;CGG repeat expansion;Chemicals;Chronic;Clinical;clinical phenotype;Clinical Treatment;Clinical Trials;Clinical/Radiologic;Cognitive;cognitive change;cohort;comorbidity;Coupling;cytokine;Data;Deposition;Development;Diagnosis;diagnostic criteria;Disease;DNA Damage;Early treatment;Evaluation;executive function;expectation;Exposure to;Family;Female;FMR1 gene;Fragile X Syndrome;Future;FXTAS;General Population;Generations;Genes;Genotype;IL6 gene;Immune;Immune System Diseases;Immunologic Factors;Impaired cognition;improved outcome;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Iron;Knowledge;Link;Magnetic Resonance Imaging;male;Measures;Mediating;Medical;Memory;men;Mental Depression;Mental disorders;Metabolic;Metalloproteases;mitochondrial dysfunction;Molecular;molecular domain;molecular marker;Motor;motor disorder;Mutation;mutation carrier;Natural History;Nerve Degeneration;Neurocognitive;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Symptoms;neuron loss;neuropsychiatric disorder;neuropsychiatry;Neuropsychological Tests;neurotoxicity;Normal Pressure Hydrocephalus;older adult;Opioid;Outcome Measure;Oxidative Stress;Pain;Pain Disorder;pain symptom;Parkinsonian Disorders;Pathology;Pattern;Penetrance;Phase;Phenotype;predictive marker;Predisposition;pressure;Prevalence;protective effect;psychiatric symptom;Psychopathology;Reactive Oxygen Species;recruit;RNA;Role;Serum;Severities;Sex Differences;Symptoms;Testing;Time;TNF gene;Toll-like receptors;Toxic effect;Toxin;Tremor;Ventricular;White Matter Disease;Woman;women versus men;X Chromosome

PROJECT_TITLE: Genotype-Phenotype Relationships in Fragile X Families


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The risk and burden of HIV are not evenly distributed anywhere in the world including in the most broadly generalized HIV epidemic settings. Characterizing the heterogeneity in susceptibility and infectivity across populations is fundamentally important to understanding the dynamics of HIV transmission and in turn, effectively measuring the population-level impact of specifically addressing the needs of those at highest risk. We have letters of support from governments, implementing partners, UNAIDS, the Global Fund and academic partners because we have proposed an ambitious, but achievable set of aims to empirically evaluate strategies to reevaluate HIV risk distribution to inform a more empiric, and ultimately, more effective HIV pandemic response.

PI_NAMEs: BARAL, STEFAN DAVID (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Africa South of the Sahara;AIDS prevention;Area;arm;Big Data;big-data science;Cameroon;Communities;Country;Data;Data Collection;data integration;Data Set;data warehouse;Drug usage;Eastern Africa;Epidemic;Epidemiologist;experience;flexibility;Funding;General Population;Goals;Government;Heterogeneity;heterogenous data;high risk;HIV;HIV risk;Household;Human immunodeficiency virus test;implementation strategy;Imprisonment;Incidence;Income;Individual;Infection;interest;Investments;Kenya;Leadership;Letters;mathematical model;Mathematics;Measures;men;Methods;migration;Modeling;models and simulation;multidimensional data;multiple data sources;National Institute of Allergy and Infectious Disease;novel;pandemic disease;pandemic response;Pattern;Pennsylvania;Persons;Population;Population Attributable Risks;Population Sizes;Predisposition;Prevalence;Prevention program;programs;Public Health Schools;Research Design;Resources;response;Risk;Senegal;sex;social media;socioeconomics;South Africa;Southern Africa;statistics;structural determinants;Surveys;Time;time use;transgender;transmission process;treatment program;Typology;Universities;Unsafe Sex;Work

PROJECT_TITLE: Leveraging Big Data Science to Focus the HIV Response in Countries with Generalized HIV Epidemics

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


PHR: The field of cancer prevention and control has grown, however, the cadre of trained and experienced researchers dedicated to cancer prevention in underserved communities grappling with persistent poverty, particularly those trained for multidisciplinary collaboration, remains too small to sufficiently advance the state of the art in cancer prevention and control. Our overall goal is to train early career investigators in the US to join a cadre of scholars who are able and purposefully lead key research efforts in multiple aspects of cancer prevention and control/population science. Long-term success in such career paths requires skills in career navigation, resilience, and career persistence that can be fostered through formal training, mentorship by assigned mentors, and role models that will be part of the Career Enhancement Core (CEC) and throughout the proposed Center for Transformative Community Driven Research to Prevent Obesity-related Cancer.

PI_NAMEs: CHANG, SHINE  (contact)

PROJECT_TERMS: Active Learning;active lifestyle;anti-cancer research;Appointment;Award;Bite;burnout;Cancer Control;cancer prevention;cancer risk;Cancer Science;career;Career Choice;career development;Collaborations;Communication;Communities;Community Actions;community organizations;community research;community setting;Data Analyses;Data Collection;Dedications;design;Development;Discipline;doctoral student;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Epidemiologist;experience;Feeling;Fostering;Funding;Goals;Grant;Health;Infrastructure;innovation;Institution;Instruction;Interdisciplinary Study;Latino Population;Lead;Learning;Malignant Neoplasms;member;Mentors;Mentorship;Methodology;multidisciplinary;novel;Obesity;Obesity associated cancer;obesity prevention;poor communities;Population;Population Sciences;Postdoctoral Fellow;Poverty;Poverty Areas;Prevention Research;Productivity;professor;Program Effectiveness;programs;promote resilience;Publications;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;resilience;Resources;responsible research conduct;Risk Factors;role model;Schedule;Science;Scientist;Seasons;Series;Shapes;skills;Structure;success;synergism;System;Texas;Time;Training;Training and Education;Training Programs;underserved community;Universities;Writing

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative: Physician-scientists have repeatedly made critical contributions to our understanding of human health and disease that have had an outsized impact on patient and population level health. However, current clinical training programs have made the physician-scientist career path less and less accessible. This program seeks to restore the pipeline of physician-scientists focused on disorders of infection, immunity and inflammation by creating a new program that integrates clinical and scientific training in a vocationally structured manner.

PI_NAMEs: CESARMAN, ETHEL ;PERMAR, SALLIE R.;RHEE, KYU Y (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Applications Grants;Area;Biology;Biomedical Research;Board Certification;career;Career Choice;career development;Cities;Clinical;Clinical Pathways;Clinical Research;clinical training;clinical translation;Communicable Diseases;Complex;Country;COVID-19 pandemic;design;Development;Development Plans;Diagnosis;Disease;Disparity;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Eligibility Determination;Environment;Etiology;Evaluation;experience;Faculty;Fellowship;flexibility;Fracture;Funding;Funding Opportunities;Future;Generations;Goals;Grant;Health;health care delivery;health care disparity;health disparity;health equity;Healthcare;Human;human disease;Immunity;Immunologics;improved;Individual;Inequity;Infection;Inflammation;Inflammatory;innovation;Institution;interest;Intervention;Investigation;Knowledge;Life Cycle Stages;life span;Medical;medical schools;Medicine;Mentors;Mentorship;Methods;Modern Medicine;Modernization;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;novel strategies;Pathology;Pathway interactions;Patients;Pediatrics;peer;Physicians;Population;Positioning Attribute;Preparation;prevent;programs;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;response;Scholarship;Science;Scientist;skill acquisition;skills;skills training;stem;Structure;Teaching Method;Time;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Vocation

PROJECT_TITLE: Tri-I Stimulating Access to Research in Residency program (Tri-I StARR - NIAID)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

PHR: The Developmental Core is designed to (1) encourage collaborations among researchers across funded centers and within the Persistent Poverty Initiative Network; (2) encourage horizontal collaborations among scientists and community partners within and outside the center to identify new, potentially fundable research opportunities, or to address emerging questions from the latest developments in the field; (3) engage new or established scientists whose specific expertise and skill set complement those of Center scientists, with emphasis on recruiting underrepresented minorities; and (4) identify and maintain a pipeline of pilot projects that may grow into full projects to accelerate generation of knowledge on effective interventions for reducing risk and suffering from cancer in the context of persistent poverty.

PI_NAMEs: LU, QIAN  (contact)

PROJECT_TERMS: Acceleration;Address;Area;behavior change;Behavioral;Cancer Control;cancer health disparity;cancer prevention;Cancer Prevention Intervention;Cancer Survivorship;Censuses;Collaborations;Communities;Community Actions;community advisory board;community collaboration;Community Health;community intervention;community partners;Complement;design;Development;Discipline;Early Diagnosis;early-career faculty;effective intervention;Ensure;evidence base;Exercise;Feedback;Financial Support;flexibility;Fostering;Funding;Generations;Germination;Goals;health communication;Home;implementation science;improved;Industrialization;innovation;Institution;interest;Intervention;Knowledge;Leadership;Malignant Neoplasms;member;Methods;Monitor;Needs Assessment;Neighborhoods;novel;nutrition;Obesity associated cancer;obesity prevention;Outcome;peer;Peer Review Grants;Persons;Pilot Projects;pilot test;poor communities;Poverty;Poverty Areas;Procedures;Process;programs;Published Comment;Quality of life;recruit;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Risk Reduction;Science;Scientist;Selection Criteria;skills;social;social determinants;Source;Talents;Testing;Training;Underrepresented Minority;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE With prevalence of dementia expected to double in the next few decades, novel insight into these diseases is desperately needed. The proposed study is a structure-driven and targeted probe into multiple key aspects of the dementia-causing tauopathies, aimed at the elucidation of fundamental mechanisms mediating tau aggregation, polymorphism, and tau tracer affinity. The insight gained from this work will be vital in future design of aggregation inhibitor therapies and positron emission tomography tracers specific for individual tauopathies.

PI_NAMEs: MALYSHKA, DMITRY  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affinity;Alzheimer's Disease;Amino Acid Sequence;Area;Automobile Driving;beta pleated sheet;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Brain;Cations;Characteristics;Chemicals;Clinical Research;clinically significant;Complex;Cryoelectron Microscopy;Data;Dementia;design;Development;Diagnosis;Disease;Disease Progression;driving force;Electrostatics;Elements;Etiology;Fellowship;Filament;Fluorescence;Future;Genetic Polymorphism;Heterogeneity;Human;hyperphosphorylated tau;imaging agent;In Vitro;in vivo;Individual;inhibitor therapy;innovation;insight;Kinetics;Length;Libraries;Ligand Binding;Ligands;Mediating;Mediator;member;Micelles;Microtubules;Modeling;Molecular Conformation;molecular dynamics;Mutation;Neurodegenerative Disorders;novel;Pathogenesis;Pathologic;permissiveness;Polymorph;Positron-Emission Tomography;Prevalence;Process;Property;Protein Isoforms;radioligand;Reaction;Recombinants;Research;Role;Sedimentation process;Shapes;Site;Site-Directed Mutagenesis;small molecule;structural biology;Structure;Sulfate;Surface;tau aggregation;tau interaction;tau Proteins;Tauopathies;Therapeutic;Therapeutic Intervention;therapeutic target;Tracer;Visualization;Work

PROJECT_TITLE: Characterizing and Targeting Filament Polymorphism in Tauopathies


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Gain-of-function mutations in activators of the complement system have been defined in rare genetic disorders and lead to increased inflammation and tissue damage. We propose here that engineering these mutant proteins to target specific cells or tissues will provide a new approach to driving and regulating localized complement activation and inflammation. In this application, we will generate proteins capable of directing complement activation to cancer cells with great immunotherapeutic potential.

PI_NAMEs: MARTINEZ BARRICARTE, RUBEN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;Amino Acid Sequence;Animal Model;Antibody Therapy;Area;Autoimmunity;autoinflammation;Automobile Driving;B-Lymphocytes;Behavior;Binding;Binding Proteins;Biological;Biological Products;Biomedical Engineering;Bypass;cancer cell;cancer immunotherapy;cancer therapy;CD19 gene;Cell Line;cell type;Cells;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;Clinical Trials;Communicable Diseases;Complement;Complement Activation;Complement Factor B;Complement Inactivators;complement system;congenital immunodeficiency;Consumption;Cytolysis;Development;Disease;efficacy testing;Engineering;experimental study;FDA approved;Future;gain of function;gain of function mutation;Genes;Hematologic Neoplasms;Human;Immune;Immune response;Immune system;Immune System Diseases;immune system function;Immunoglobulin Fragments;Immunologics;Immunology;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vitro testing;in vivo;Inflammation;inhibitor;innovation;insight;interest;Invaded;Knowledge;Learning;Leucocytic infiltrate;Link;Literature;Malignant Neoplasms;Mediating;Mendelian disorder;Methods;Mining;Mission;Monoclonal Antibodies;mouse model;Mus;mutant;Mutate;Mutation;Nature;neoplastic cell;novel;novel strategies;novel therapeutics;Organism;overexpression;pathogen;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Physiological;Plasma;preclinical study;prevent;Procedures;Protein Fragment;Proteins;Publishing;rare genetic disorder;Research;Resistance;Safety;safety assessment;Sampling;side effect;Solid;Solid Neoplasm;Specificity;Surface;System;Testing;Therapeutic;therapy development;Tissues;Translating;Tropism;tumor;Tumor Cell Line;Tumor Markers;Work

PROJECT_TITLE: Gain-of-function complement activators as a new class of immunotherapeutic molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Social Determinants of Health

PHR: The Engagement Core within the Center for Transformative Community-driven Research to Prevent Obesity-related Cancer (the Center) emphasizes the vital role of active stakeholder engagement in accelerating research participation and achieving impactful outcomes. By focusing on communities affected by persistent poverty and building on established trust foundations, such as the Be Well Communities model in Acres Homes, the core aims to foster deeper community-academic relationships. The Center's initiatives include: (1) Leveraging our Be Well Acres Homes steering committee as the Center community advisory board; (2) Enhancing community-engaged research capacities; (3) Providing experiential service-learning experiences for trainees and investigators; (4) Promoting effective messaging to engage the Acres Homes community in cancer prevention research.

PI_NAMEs: MCNEILL, LORNA H. (contact)

PROJECT_TERMS: Acceleration;Achievement;Affect;base;Benchmarking;cancer prevention;Collaborations;Communities;community academic partnership;community advisory board;community center;community engaged research;community engagement;community organizations;Consultations;Decision Making;experience;fly;forging;Fostering;Foundations;Health;Health Professional;Home;Individual;Institution;interest;Investments;Joints;Methods;Modeling;multidisciplinary;novel;Obesity associated cancer;obesity prevention;Outcome;Poverty;Poverty Areas;Prevention Research;Program Development;Public Health Practice;public health research;Research;Research Personnel;Research Support;response;Role;Science;service learning;Side;success;Testing;Trust;Voice;Workforce Development

PROJECT_TITLE: Engagement Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: WORCESTER

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: OVERALL – PROJECT NARRATIVE Vitiligo is an autoimmune disease of the skin that causes disfiguring white spots, with significant impact on those with darker skin. We will leverage existing data that we have already generated directly from the skin of vitiligo patients, a multidisciplinary team of leading investigators, cutting edge, translational tools designed for discovery, and an innovative strategy to discover how skin cells coordinate autoimmunity during vitiligo. This will support the development of advanced new treatment approaches for vitiligo and similar autoimmune diseases.

PI_NAMEs: HARRIS, JOHN E (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Achievement;Advanced Development;Affect;Affinity;Antigens;Architecture;Atlases;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biological Assay;Cell Communication;Cell Physiology;cell type;Cells;Cellular Assay;Center for Translational Science Activities;Characteristics;chemokine;Clinical;Clone Cells;Communication;Complex;Computing Methodologies;Cues;cytotoxic CD8 T cells;Data;design;Disease;disease phenotype;Disease Progression;Ensure;Epidermis;Fluorescent in Situ Hybridization;Genetic Risk;Goals;Human;human tissue;Inflammation;Inflammatory;innovation;Insulin-Dependent Diabetes Mellitus;Knowledge;Lesion;Ligands;long term memory;Maps;melanocyte;Memory;Modeling;Molecular;Monitor;multidisciplinary;Multiomic Data;multiple omics;Multiple Sclerosis;novel therapeutic intervention;Organ;outreach;Pathogenesis;Pathway interactions;Patients;Pigments;Positioning Attribute;receptor;Recording of previous events;Research;Research Personnel;Resolution;response;risk variant;Sampling;Series;Signal Transduction;single cell technology;Skin;skin biopsy;skin disorder;Structure;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;tool;transcriptomics;Translating;translational goal;Translational Research;Vitiligo;White Spots

PROJECT_TITLE: Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT)


NIH_SPENDING_CATS: Autoimmune Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Achievement;Advisory Committees;Affect;Atopic Dermatitis;Autoimmune Diseases;Autoimmunity;Budgets;Caregivers;Cell Culture Techniques;Cells;Center for Translational Science Activities;chemokine;clinical care;Clinical Research;Collaborations;collaborative environment;Communication;Communities;Complex;Data;Dermatologist;Disease;Disputes;Education;Ensure;Evaluation;Event;experience;FDA approved;Funding;General Population;Generations;Genetic Risk;Goals;Grant;health disparity;Human;Human Resources;Immunologist;improved;Individual;Information Dissemination;innovation;insight;Institution;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;Knowledge;Leadership;Left;Maps;meetings;Modeling;multidisciplinary;multiple omics;Multiple Sclerosis;Nature;neoantigens;Occupational activity of managing finances;Outcome;outreach;outreach program;Participant;Pathogenesis;Patients;Physicians;Population;Progress Reports;Psoriasis;psychologic;Publications;Research;Research Personnel;research study;Resolution;Resources;Rheumatoid Arthritis;risk variant;Sampling;Schedule;Scientific Advances and Accomplishments;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;skin lesion;success;System;T-Cell Receptor;T-Lymphocyte;Tissues;tool;transcriptomics;Translational Research;treatment strategy;United States National Institutes of Health;Vitiligo;White Spots;Workload

PROJECT_TITLE: P50-Admin Core-Harris/Garb


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Genetics;Human Genome

PROJECT_TERMS: Address;Affect;Antibodies;Atlases;Autoimmunity;Biological Process;Bulla;Cell Communication;cell type;Cells;cellular imaging;Center for Translational Science Activities;Clone Cells;Communication;Complement;Complex;Data;Dendritic Cells;Dermal;design;Epidermis;Equilibrium;Fluorescent in Situ Hybridization;Freezing;Gene Targeting;Genes;Genetic Transcription;Goals;health disparity;Image;Immune;immune cell infiltrate;improved;in silico;In Situ;Individual;Inflammation;Inflammatory;innovation;insight;interest;keratinocyte;Knowledge;Label;Learning;Lesion;Ligands;Location;Maps;melanocyte;Messenger RNA;Microscope;Modification;multiple omics;Normal tissue morphology;Organ;Pathogenesis;Pigments;Population;Positioning Attribute;Privatization;Process;Punch Biopsy;receptor;Receptor Cell;receptor expression;Research;Resolution;RNA;Signal Transduction;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;Spatial Distribution;Structure;T cell clonality;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Tissues;Transcript;transcriptome;transcriptomics;treatment strategy;Vitiligo;White Spots

PROJECT_TITLE: High Resolution Spatial Transcriptomics using seq-FISH+


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Heart failure (HF) is a major health problem in the United States that affects nearly 5.7 million Americans. Compelling evidence suggests that defects in mitochondrial function are implicated in HF development, however, how cardiomyocyte mitochondrial-derived stress impacts cardiac contractile function, metabolism and electrophysiology remains incompletely understood. This project will employ an innovative luminoptogenetic technology to specifically manipulate cardiomyocyte mitochondria in intact hearts to delineate the role of mitochondrial dysfunction in the pathophysiology of HF.

PI_NAMEs: ZHOU, LUFANG  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Adult;Affect;American;Animals;Antioxidants;Biochemical;Biogenesis;Cardiac;Cardiac Myocytes;Cell Death;Cell Physiology;cell type;Cells;Chronic;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosol;cytotoxicity;Defect;Dependence;Dependovirus;Development;Diagnosis;Dilated Cardiomyopathy;dosage;Dose;Electrophysiology (science);Engineering;Equilibrium;Etiology;Functional disorder;Future;Gene Delivery;Genes;genetic approach;Goals;Health;Heart;Heart failure;heart function;heart metabolism;Histologic;Homeostasis;Hour;Impairment;In Vitro;in vivo;Injury;Inner mitochondrial membrane;innovation;innovative technologies;Light;light emission;light gated;Lighting;Link;Luciferases;luciferin;Measures;Mediating;Membrane Potentials;Metabolism;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;mortality;mouse model;Mus;novel;Organ;Outcome;Oxidation-Reduction;Pathologic;Patients;pharmacologic;preclinical study;prevent;Production;promoter;protein expression;Pump;Quality Control;Reactive Oxygen Species;Research;Rhodopsin;Role;side effect;Signal Pathway;Specificity;Stimulus;Stress;Survival Rate;targeted treatment;Technology;Testing;Translations;Treatment Failure;United States

PROJECT_TITLE: Delineate the Pathophysiological Effect of Cardiomyocyte-specific Mitochondrial Stress

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Given the gravity of the HIV epidemic in the South and globally and the new DHHS initiative that proposes to end the US HIV epidemic in the next 10 years, fostering the next generation of translational HIV scientists across the HIV research continuum is of utmost importance. To accomplish this, we propose a new HIV T32 training program for post-doctoral fellows at Emory University. Post-doctoral trainees will emerge from our T32 program ready for scientific independence and with a deep understanding of how their research fits into the multidirectional and multidisciplinary framework of HIV research with the long-term goal of ending the HIV epidemic.

PI_NAMEs: CHAHROUDI, ANN M;KELLEY, COLLEEN F (contact);SULLIVAN, PATRICK SEAN

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TITLE: Emory Training Program in Translational Research to End the HIV Epidemic

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Genetics;Human Genome;Immunotherapy

PI_NAMEs: KENT, SALLY CHOATE (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;Animal Model;Antigen Targeting;Antigenic Specificity;Antigens;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biological Assay;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Culture Techniques;Cell Physiology;Cell Separation;Cells;Center for Translational Science Activities;Characteristics;Clinical;clinical phenotype;Clonality;Clone Cells;Communication;Complex;Computing Methodologies;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Disease;disease phenotype;Effector Cell;effector T cell;Epidermis;Epigenetic Process;Fluorescent in Situ Hybridization;Gene Expression Profile;Genetic;Genetic Risk;health disparity;Human;human tissue;Immune;Immunohistochemistry;In Vitro;in vivo;Individual;Infiltration;Inflammatory;Insulin-Dependent Diabetes Mellitus;Lesion;Location;Maintenance;Mediating;melanocyte;Microtome - medical device;migration;Modeling;Molecular;mouse model;Multiomic Data;multiple omics;Multiple Sclerosis;novel therapeutic intervention;Organ;Organ Culture Techniques;Pathway interactions;Patients;Phenotype;Pigments;Play;Population;Positioning Attribute;programs;Proteins;recruit;Regulatory T-Lymphocyte;Resolution;response;restraint;risk variant;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;skin lesion;Slice;spatial relationship;Stable Disease;T cell clonality;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic Intervention;Tissues;tool;Transcript;Translational Research;Trichrome stain method;vibration;Vitiligo;White Spots

PROJECT_TITLE: Autoreactive T Cell Function in Vitiligo


PHR: PROJECT NARRATIVE The Emory CFAR will contribute to ending the HIV epidemic by accelerating the highest caliber translational research — fostering team science, equity, and multidirectional stakeholder engagement. We will strive to build community trust in research through the intentional inclusion of key stakeholders at all stages of the research pipeline. We will achieve our goals by providing innovative services, tools, expertise, and access to state-of- the-art equipment through an Administrative Core, a Developmental Core, five Science Cores (Biostatistics and Bioinformatics; Clinical Research; Prevention and Implementation Sciences; Systems Immunology; and Virology and Molecular Biomarkers); and two Scientific Working Groups (SWGs) - Health Equity and Next Generation Therapeutics.

PI_NAMEs: CHAHROUDI, ANN M;DEL RIO, CARLOS  (contact);KELLEY, COLLEEN F

PROJECT_TERMS: Acceleration;access disparities;Acquired Immunodeficiency Syndrome;African American;Appointment;Area;Award;Basic Science;bench to bedside;Bioinformatics;Biometry;Caliber;Clinical Research;Collaborations;Communities;community advisory board;community building;community engagement;County;Coupled;Development;Doctor of Philosophy;Epidemic;Equipment;Equity;Fostering;Funding;Geographic Locations;Geography;Goals;Grant;health care availability;health equity;health equity promotion;Hispanic;Historically Black Colleges and Universities;HIV;Home;Immunology;implementation science;improved;innovation;Internet;Investments;Latinx;life span;Location;member;minority investigator;Mission;molecular marker;Morehouse School of Medicine;next generation;novel therapeutics;Peer Review;Personal Satisfaction;Persons;Phase;Population;pre-clinical research;Prevention;Public Health;Publications;recruit;Research;Research Personnel;Research Priority;Risk;Role;Science;Services;System;Teacher Professional Development;tool;Training;Translating;Translational Research;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;working group

PROJECT_TITLE: Center for AIDS Research at Emory University


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome

PI_NAMEs: GARBER, MANUEL  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Affect;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Assay;Bulla;CD8-Positive T-Lymphocytes;Cell Communication;Cell Culture Techniques;Cell Physiology;cell type;Cells;Center for Translational Science Activities;chemokine;Chromatin;chromatin remodeling;Chromatin Structure;Communication;Complex;CXCL9 gene;cytokine;Data;data communication;Development;Disease;Disease Progression;Environment;epigenetic memory;Epigenetic Process;Event;experience;extracellular;Flow Cytometry;Genes;Homeostasis;Immune;Immunity;improved;In Vitro;in vitro Model;in vivo;insight;Intercellular Fluid;interest;keratinocyte;Knowledge;Lesion;Ligands;Liquid substance;Location;long term memory;Maps;MCHR1 gene;Measures;melanocyte;Memory;migration;Modeling;Modification;multiple omics;novel;Pathogenesis;Pathway interactions;Patients;Phenotype;Pigments;prevent;receptor;Recombinant Chemokine;Recurrent disease;Relapse;Research;Research Methodology;Resolution;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Skin;skin disorder;Suction;T-Lymphocyte;Techniques;TGFB2 gene;three dimensional cell culture;Tissues;transcriptomics;Transforming Growth Factor Beta 2;Translational Research;Vitiligo;White Spots

PROJECT_TITLE: Cell-Cell Communications and Tissue Memory in Vitiligo


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Physical Activity;Prevention;Telehealth

ORG_CITY: Aurora

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The overall project goal is to address the critical need for self-care strategies to improve the physical and psychological health of older family care partners caring for patients with heart failure. This proposed study is relevant to public health because older family care partners often experience high caregiving burden that results in physical function decline, psychological distress, sleep disturbance, and poor health status. Implementation of this project's tailored physical activity coaching program, which uses integrated digital health technologies, will have the potential to support self-management and enhance the health and well-being of aging family care partners.

PI_NAMEs: BAIK, DAWON  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;Affect;age related;Aging;attentional control;behavior change;behavioral health intervention;biobehavior;Cardiac;Cardiovascular Diseases;care giving burden;care recipients;career;career development;Caregiver support;caregiving;Caring;Chronic;Chronic Disease;clinical trial implementation;Clinical Trials;college;Colorado;Communities;Complex;COVID-19 pandemic;Data;Dementia;design;Development;Development Plans;digital health;Discipline of Nursing;Disease;efficacy study;Emotional;Ensure;Environment;Exercise;exercise intervention;experience;Family;family burden;family support;Feedback;field study;fitbit;Foundations;Frequencies;Friends;Goals;Health;Health Benefit;Health Promotion;Health Status;Health Technology;Healthcare;Heart failure;Home;improved;Individual;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Malignant Neoplasms;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;mHealth;novel;older adult;Older Population;Outcome;participant retention;Patient Care;Patients;Perception;Personal Satisfaction;Persons;Physical activity;physical conditioning;Physical Function;Population;Population Heterogeneity;posthospitalization care;Preparation;prevent;primary outcome;programs;psychologic;psychological distress;psychological outcomes;Public Health;Public Health Informatics;Quality of life;Randomized;Reporting;Research;research and development;Risk;sedentary;Self Care;Self Efficacy;Self Management;skills;Sleep;Sleep disturbances;sleep health;Social isolation;Social support;Spouses;stressor;Symptoms;tailored text messaging;Technology;telehealth;Testing;Text Messaging;Time;training opportunity;Universities;usability;Videoconferencing;wearable data;wearable sensor technology

PROJECT_TITLE: Digital Health Physical Activity Program for Older Family Care Partners of Patients with Heart Failure

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Two photon miniaturized microscopy can be used to record the activity of axons, dendrites, or cells located in deep tissue in freely behaving animals. In this proposal, we propose to develop open-source 2-photon miniaturized microscopes with enlarged field-of-view and volumetric imaging capability. We will disseminate these tools to the neuroscience community to drive new research directions.

PI_NAMEs: AHARONI, DANIEL ;BLAIR, HUGH T;CHURCHLAND, ANNE KATHRYN;GOLSHANI, PEYMAN  (contact);SILVA, ALCINO J.;VAZIRI, ALIPASHA

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Animals;Anterior;Axon;Behavior;Brain;Bypass;Calcium;Cells;cingulate cortex;Collaborations;Communities;cost;Coupled;Custom;Cytoplasmic Granules;data acquisition;Decision Making;Dendrites;design;design,build,test;Educational process of instructing;Educational workshop;Elements;Ensure;equipment acquisition;Excision;Fiber;Glutamates;Hippocampus;Image;imaging capabilities;insight;Lateral;lens;Letters;Link;Memory;memory encoding;meter;Methods;Microscope;Microscopy;miniaturize;Mus;neural network;Neurons;Neurosciences;nonhuman primate;novel;open source;open source tool;Operative Surgical Procedures;Optics;Parietal Lobe;Pattern;Persons;photonics;Photons;Population;Production;Publishing;Rattus;Recording of previous events;Research;Research Personnel;Resolution;Role;Scanning;sensor;Social Interaction;spatial memory;Specific qualifier value;Structure;System;Techniques;Technology;Testing;Thalamic structure;theories;Tissue imaging;Tissues;tool;two photon microscopy;two-photon;wiki;Work

PROJECT_TITLE: Open-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: DEL RIO, CARLOS  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Area;Award;Basic Science;Bioinformatics;Biometry;Clinical Research;Clinical Sciences;Communication;Communities;community engagement;Crowns;Development;dissemination strategy;diversity and inclusion;Ensure;Epidemic;experience;Faculty;Funding;Goals;Grant;Growth;Health;health equity;health equity promotion;Health Sciences;HIV;Immunology;implementation science;innovation;Institution;Investments;Leadership;leadership development;member;Mentors;Mission;molecular marker;multidisciplinary;next generation;novel therapeutics;Prevention;Process;programs;recruit;Research;Research Personnel;Research Priority;Resource Allocation;Resources;Role;Science;Services;Strategic Planning;success;System;tool;Training Programs;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;Work;working group

PROJECT_TITLE: Core A: Administrative


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: WALDROP, DRENNA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Award;career;Categories;Collaborations;Communication;community engagement;design;Development;Equity;ethnic diversity;Evaluation;expectation;falls;Fostering;Funding;Funding Opportunities;Goals;Grant;HIV;holistic approach;Individual;innovation;Institution;interest;Investments;K-Series Research Career Programs;Length;meetings;member;Mentors;Methods;minority investigator;next generation;Participant;process improvement;programs;racial diversity;recruit;Research;Research Activity;Research Personnel;Research Support;Resources;Science;Scientist;Series;Services;skills;Strategic Planning;Structure;Thinking;Time;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;working group

PROJECT_TITLE: Core B: Developmental


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: COOPER, HANNAH LF (contact)

PROJECT_TERMS: Academia;Acceleration;Acquired Immunodeficiency Syndrome;AIDS prevention;Applications Grants;archive data;Behavioral Sciences;Caliber;Cellular Phone;Collaborations;Communities;Consultations;Continuity of Patient Care;Data;data access;data archive;Data Set;Dedications;Development;Educational workshop;effective intervention;efficacious intervention;Epidemic;Equipment;Evidence based intervention;Funding;Goals;Grant;health equity;HIV;Hour;Human immunodeficiency virus test;implementation determinants;implementation framework;implementation science;Intervention;marginalized population;meetings;member;Methods;mHealth;Modality;Modeling;Names;new technology;novel;online repository;outreach;Participant;Persons;pre-exposure prophylaxis;Prevention;programs;Research;Research Personnel;Research Priority;Resources;scale up;Science;Series;Service provision;Services;Social Behavior;success;successful intervention;Surveys;System;Tablets;Technology;therapy development;Time;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities;uptake;virtual;web platform;Writing

PROJECT_TITLE: Core C: Prevention and Implementation Sciences Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Substance Misuse;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: OFOTOKUN, IGHOVWERHA  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acquired Immunodeficiency Syndrome;Acute;Address;Adherence;Adolescent;Adolescent and Young Adult;AIDS prevention;Area;Award;Basic Science;biobank;Biological;Biological Specimen Banks;Caliber;career development;Career Mobility;Caring;Child;Childhood;Clinical;clinical database;Clinical Research;Clinical Trials;clinically relevant;co-infection;cohort;Collaborations;Communities;community advisory board;community engagement;comorbidity;Consultations;Country;COVID-19 vaccine;Data;Data Collection;data sharing;Development;Disease;disease registry;diverse data;Electronic Health Record;Epidemic;Equity;Faculty;Fostering;Functional disorder;Funding;Goals;Health system;Healthcare;Hepatitis B Virus;Hepatitis C co-infection;high risk;HIV;HIV Infections;Human Subject Research;improved;Individual;infection risk;innovation;International;Laboratories;Link;Medical center;member;men;men who have sex with men;microbicide;Minority Men;Minority Women;Mission;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;next generation;Pathogenesis;Patient Care;Patients;Persons;Play;Population;Population Heterogeneity;pre-clinical research;pre-exposure prophylaxis;Pregnant Women;Prevention;programs;Publications;Registries;repository;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;research study;Research Support;Resources;Role;Safety;Sampling;Science;Scientist;Services;Specimen;tool;Training;Training Support;transgender;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Vaccines;Veterans;Woman;Work

PROJECT_TITLE: Core D: Clinical Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: LYLES, ROBERT H (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advocate;Applications Grants;Area;Award;Behavioral;Bioinformatics;Biometry;career development;Case Report Form;Clinical;Clinical Research;Collaborations;Consultations;Data;Data Analytics;database design;design;Development;Disease;Doctor of Philosophy;Ensure;Epidemic;epidemiology study;Faculty;Fostering;Funding;Future;Goals;Grant;HIV;Infectious Diseases Research;innovation;Leadership;Link;member;Mentorship;Methodology;Mission;Modernization;next generation;Participant;Positioning Attribute;programs;Publications;Qualifying;recruit;Registries;Research;Research Design;Research Methodology;Research Personnel;Role;Science;Services;social;sound;Statistical Methods;success;synergism;System;Talents;Time;Training;Universities;working group

PROJECT_TITLE: Core F: Biostatistics and Bioinformatics


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: JOHNSON, R. PAUL (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;analytical tool;ATAC-seq;Bioinformatics;Biometry;Caliber;Cell Physiology;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Collaborations;Communities;Coupled;Data;Data Analyses;Data Set;design;Doctor of Philosophy;Education;Educational Status;Epidemic;Epigenetic Process;Epitopes;Equipment;Equity;experimental analysis;Experimental Designs;experimental study;Flow Cytometry;Fostering;Funding;Goals;Grant;Growth;high dimensionality;high throughput analysis;HIV;HIV Infections;Human;Immune;immune function;Immune response;immunodeficiency;Immunology;indexing;Infection;instrument;Leadership;member;multiple omics;nonhuman primate;novel strategies;Pathogenesis;Positioning Attribute;prevent;Prevention;programs;Proteomics;Research;Research Personnel;Science;Services;single cell ATAC-seq;single-cell RNA sequencing;SIV;support tools;System;Techniques;tool;Training;Training Programs;Transcript;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Virus Diseases

PROJECT_TITLE: Core H: Systems Immunology


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Microbiome;Prevention;Substance Misuse

PI_NAMEs: SILVESTRI, GUIDO  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Alveolar Macrophages;antiretroviral therapy;Behavioral;behavioral study;Biological Assay;Caliber;career;Cells;Cerebrospinal Fluid;Certification;CLIA certified;Clinical;Clinical Research;Clinical Trials;Clinical Virology;co-infection;Communities;Consultations;COVID-19 pandemic;Cytomegalovirus;deep sequencing;Development;DNA;Doctor of Philosophy;Epidemic;Equity;Evolution;Fostering;Genes;Genitalia;Goals;Growth;gut microbiome;Hepatitis B Virus;Hepatitis C virus;HIV;HIV Infections;HIV/AIDS;Human Milk;Human Subject Research;Individual;Infrastructure;innovation;integration site;Maintenance;Measures;microbiome sequencing;Mission;Modeling;Molecular;Molecular Diagnostic Testing;molecular marker;multidisciplinary;nonhuman primate;novel;novel therapeutics;Nucleic Acids;Pathogenesis;Performance;Plasma;Prevention;Rectum;Research;research clinical testing;Research Personnel;Resources;response;RNA;Science;Seminal fluid;sequencing platform;Services;Sexually Transmitted Diseases;simian human immunodeficiency virus;SIV;Specimen;Standardization;Syndrome;Techniques;Tissues;tool;Training;Training Activity;Translational Research;translational study;transmission process;Universities;Validation;Variant;Viral;Viral Load result;Viral reservoir;virology;Virus;Virus Integration

PROJECT_TITLE: Core J: Virology and Molecular Biomarkers


ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative This project investigates physiologic interactions between bone and adipose tissue during the response to two signals that stimulate new bone formation. Our hypothesis predicts that adipose tissue lipolysis induced by intermittent parathyroid hormone administration or exercise supplies fatty acids necessary to fuel bone formation by osteoblasts. Completion of this work may ultimately lead to the development of novel approaches for the treatment of both osteopenia and metabolic dysfunction.

PI_NAMEs: RIDDLE, RYAN C (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Ablation;Acute;Address;Adipocytes;Adipose tissue;Adrenergic Agents;Anabolism;Architecture;Biochemistry;Biology;bone;Bone Formation Inhibition;bone mass;Bone Matrix;bone strength;Bone Tissue;C57BL/6 Mouse;Carbon;Carnitine Palmitoyltransferase I;Cell Line;Cell Lineage;Citric Acid Cycle;Collaborations;Data;Deposition;Development;Distant;Energy-Generating Resources;Enzymes;Epidemic;Exercise;Exercise Physiology;Exposure to;extracellular;fatty acid oxidation;Fatty Acids;Gene Expression;Genetic;Height;Homeostasis;Hormones;Impairment;In Vitro;in vivo;Interleukin-6;Label;Laboratories;Lipase;lipid metabolism;Lipolysis;long chain fatty acid;LoxP-flanked allele;Manuscripts;Mass Spectrum Analysis;Mediating;Metabolic dysfunction;microCT;Mitochondria;Modification;Monitor;mouse model;Mus;novel strategies;Obesity;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteopenia;oxidation;Palmitates;Performance;Physiologic calcification;Physiological;Physiology;Productivity;PTH gene;receptor;response;Running;Signal Transduction;skeletal;skeletal stem cell;Societies;Stimulus;Therapeutic;Therapeutic Effect;Tissues;Training;Transgenic Mice;treadmill;Triglycerides;uptake;Work

PROJECT_TITLE: Bone-Adipose Interactions During Skeletal Anabolism

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: SEASIDE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CALIFORNIA STATE UNIV,  MONTEREY BAY

PHR: PROJECT NARRATIVE This project establishes a dynamic training program that addresses the goal of diversifying the genomics workforce. By providing support for mentored research experiences, professional and identity development, and genomics-specific educational opportunities, we will create a system that will fully prepare our GREAT scholar for careers in the genome sciences.

PI_NAMEs: ISLAM, SHAHIDUL ;JUE, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: TINGLE, SHARNA R

PROJECT_TERMS: Address;Affinity;Algorithms;Area;Articulation;Bioinformatics;Biological Sciences;Biology;California;career;Career Choice;cohort;Collaborations;Communication;Communities;computer science;Data;Dedications;Development;Dryness;Education;education research;Educational workshop;Enrollment;Environment;ethical, legal, and social implication;Ethics;experience;Exposure to;Faculty;faculty mentor;falls;Financial Support;Foundations;genome browser;genome sciences;Genomics;Goals;graduate school preparation;Grant;Informatics;innovation;Instruction;legal implication;Low Income Population;Mathematics;Mentors;Mentorship;peer;peer coaching;Positioning Attribute;pre-doctoral;Professional Role;programs;Readiness;recruit;Research;Research Project Grants;Research Training;Resources;responsible research conduct;role model;Scholarship;Science;Scientist;Self Efficacy;Series;skills;Social Impacts;social implication;Solid;statistics;STEM field;Structure;student participation;student training;Students;summer program;summer research;symposium;System;tool;Training;Training Programs;Travel;undergraduate research experience;undergraduate student;Underrepresented Minority;Universities;Work;Writing

PROJECT_TITLE: GREAT Opportunities in Genome Science

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: PROJECT NARRATIVE This proposal aims to develop physician-scientists through integrating rigorous scientific investigation and compassionate clinical training through our multi-institutional MD/PhD program. We enable training of a diverse national trainee pool in a wide variety of fields from engineering and biomedical devices, systems neuroscience, immunotherapy to development of novel therapeutics and discovery of molecular basis for disease. Trainees supported by this grant will become the future biomedical physician-scientists who will work towards increasing our understanding of fundamental pathogenesis of disease and cutting-edge approaches to treat patients.

PI_NAMEs: WILSON, CARA C. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Microbiome

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose a set of experiments to characterize the periocular eyelid microbiome of participants in the TwinsUK registry, and to utilize these data to establish the hereditary and environmental factors responsible for shaping this microbiome.

PI_NAMEs: VAN GELDER, RUSSELL N. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adult;Bacteriophages;Bilateral;Blepharitis;Catalogs;Clinical;cohort;Data;Data Set;Databases;Disease;Dizygotic Twins;DNA;DNA Viruses;Dry Eye Syndromes;Enrollment;Environmental Risk Factor;epidemiologic data;experimental study;Eye;Eye diseases;Eyelid structure;Future;Genetic;Genetic Determinism;Genomics;Goals;Heritability;Hordeolum;Individual;Inherited;Intervention;Life Style;lifestyle factors;Meibomian Cyst;meibomian gland;metagenomic sequencing;Metagenomics;metatranscriptomics;microbial;microbial community;microbial composition;microbiome;microbiome composition;Monozygotic twins;novel;Nutritional;ocular microbiome;ocular surface;Organism;Outcome;Participant;Questionnaires;recruit;Registries;Research;RNA;RNA Viruses;Sampling;Shapes;Structure;Surveys;Swab;Time;transcriptome sequencing;United Kingdom;Variant;Virus;volunteer

PROJECT_TITLE: Determinants of the periocular microbiome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Mutations in the proteasome shuttle factor UBQLN2 cause ALS-FTD in humans, and the mechanism of disease is not known. I discovered that UBQLN2 regulates the abundance of a poorly understood, proteolytically active and nucleic acid-binding protein PEG10, which is elevated in spinal cords of ALS patients. Here, we propose to deeply examine the (1) abundance and activity of PEG10 in disease, the (2) precise contribution of PEG10 to disease in vitro and in vivo, and (3) the molecular rules governing UBQLN2’s facilitated degradation of PEG10.

PI_NAMEs: WHITELEY, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;ALS patients;American;Animal Model;Animals;Axon;Binding;Binding Proteins;Biology;Brain;brain tissue;Cell model;Cell Nucleus;Cells;Client;Complement;Cytosol;Data;Defect;Development;Diagnosis;Disease;disease model;Disease Pathway;disease phenotype;drug development;effective therapy;familial amyotrophic lateral sclerosis;Family;fighting;frontal lobe;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;Germ Lines;Goals;Histologic;Human;Hydrophobicity;Impaired cognition;In Vitro;in vivo;Induced Neurons;Inheritance Patterns;Investigation;Laboratories;Lead;life span;Link;Mediating;misfolded protein;Modeling;Molecular;molecular modeling;motor impairment;Motor Neurons;multicatalytic endopeptidase complex;Mus;Mutation;Names;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel;Nucleic Acid Binding;nucleic acid binding protein;Nucleocapsid;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Placentation;Process;programs;Protease Domain;protein degradation;Protein Fragment;Proteins;Proteome;Proteomics;Publishing;Research;Research Personnel;Rest;Retrotransposon;Retroviridae;Retrovirus Proteins;Role;Spinal Cord;sporadic amyotrophic lateral sclerosis;Structure;Symptoms;Synapses;Therapeutic;Tissues;ubiquilin;Up-Regulation;Viral;Virus;Work;Zinc Fingers

PROJECT_TITLE: Investigation of UBQLN2 in neuronal dysfunction and ALS-FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Nutrition

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Social interactions between animals and between humans can be explained quite well when the costs and benefits of specific actions are taken into consideration, but the genetic and neuronal mechanisms driving these types of context-dependent behavioral choices remain poorly characterized. Using the Drosophila fruit fly, we aim to determine the genes, neurons, and neural circuits that modulate behavior in response to two conditions that affect the perceived payoff of a fight: 1) social defeat, which increases perceived risk, and 2) nutritional deficits, which increase potential benefit. Similarities between flies and humans regarding the genes involved in social behaviors make it highly likely that results from this project will provide a foundation for understanding how genetic variation, especially those associated with neuronal disorders, can influence decision-making processes during human interactions.

PI_NAMEs: ASAHINA, KENTA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Affect;Aggressive behavior;Amino Acids;Animal Behavior;Animals;Automobile Driving;base;Behavior;Behavioral;Behavioral Paradigm;Computing Methodologies;Costs and Benefits;Decision Making;deprivation;Development;Disease;Drosophila genus;Drosophila melanogaster;Environment;experience;experimental study;feeding;Female;fighting;flexibility;fly;Food;Foundations;Gene Expression;gene function;Genes;Genetic;genetic manipulation;Genetic Transcription;Genetic Variation;Goals;Human;male;Molecular;neural;neural circuit;neurogenetics;neuronal circuitry;Neurons;novel;Nutrient;nutrition;Nutritional;Outcome;Partner in relationship;Process;Research;Resolution;response;Risk;Social Adjustment;Social Behavior;social defeat;Social Interaction;System;Testing;tool;Yeasts

PROJECT_TITLE: Genetic factors controlling the intensity of social behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Aging;Biotechnology;Complementary and Integrative Health;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE We propose to continue our efforts as part of a consortium for large-scale production and phenotyping of knockout mice. The generation of mutant alleles and broad-based, systematic phenotyping will reveal gene contribution to mammalian biology and define new functions and pathways underlying the mechanisms of disease. All mouse lines and their phenotyping will be publicly released as they become available.

PI_NAMEs: HEANEY, JASON D. (contact);HSU, CHIH-WEI LOGAN;LANZA, DENISE GRANT

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adopted;Adult;Alleles;Anatomy;Area;base;behavior test;Bioinformatics;Biological Process;Biology;Catalogs;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;college;Communities;cost effective;CRISPR/Cas technology;Cryopreservation;Data;Data Coordinating Center;data quality;Defect;design;Development;Disease;Embryo;Ensure;Essential Genes;Exons;experience;Foundations;Funding;Future;gene function;Generations;Genes;Genetic;genome editing;Germ;Goals;Human;human disease;improved;in vivo;informatics infrastructure;insight;International;Knockout Mice;large scale production;Machine Learning;Mediating;Medicine;Methodology;microCT;mouse genome;Mus;mutant;Mutant Strains Mice;novel;novel strategies;Pathway interactions;Phase;Phenotype;phenotypic data;preclinical study;Procedures;Production;Program Development;Proteins;Quality Control;repository;Research;Research Personnel;research study;Resources;Role;Site;Standardization;Techniques;Technology;technology development;Testing;Time;tool;translational study;United States National Institutes of Health;Work;X-Ray Computed Tomography

PROJECT_TITLE: The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2)


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Inappropriate action of neutrophils is often associated with severe complications of pneumonia. Neutrophils actively change the genes and proteins they produce as they travel to the lungs during infection. Our proposed study will examine how the changes in genes produced affects the way neutrophils function in pneumonia.

PI_NAMEs: TRABER, KATRINA  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Affect;Air;Alveolar;Automobile Driving;Biology;biomarker identification;Bone Marrow;Cell membrane;Cell Separation;Cells;Circulation;Clinical;COVID-19 pandemic;Cytokine Signaling;Data;Development;Environment;Epithelium;Equilibrium;Exposure to;Flow Cytometry;Future;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Heterogeneity;Immune response;Immune System Diseases;Immunologics;In Vitro;in vivo;in vivo Model;Infection;Inflammatory;Injury;Intervention;Knowledge;Label;Lead;Liquid substance;Location;loss of function;Lung;Maintenance;Mediating;Metabolism;migration;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Mus;neutrophil;novel;novel marker;Outcome;pathogen;Pathway interactions;Pneumonia;pneumonia model;Population;programs;Proteins;Recording of previous events;response;single-cell RNA sequencing;Site;Sorting;Stimulus;Surface;Testing;Therapeutic;Thinness;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Travel;Up-Regulation;Work

PROJECT_TITLE: Transcriptional Regulation of Migrating Neutrophils during Pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

PHR: Project Narrative This project is a multicenter, randomized, double-masked, placebo-controlled clinical trial designed to test the hypothesis that oxidative damage is a major contributor to cone cell death in retinitis pigmentosa (RP) and that long-term oral N-acetylcysteine will promote cone survival and prevent severe visual disability in RP. It has the potential to provide a treatment that can slow visual function loss and that applies to all patients with RP regardless of the causative mutation. It will also answer the scientific questions that to what extent does oxidative damage contribute to cone cell death in RP and is it a target for the development of additional treatments.

PI_NAMEs: KONG, XIANGRONG  (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Acetylcysteine;adaptive optics scanning laser ophthalmoscopy;Adverse event;Age;aged;Appointments and Schedules;Area;arm;Blindness;causal variant;Cause of Death;Cell Death;Certification;Clinical;Clinical Management;clinical research site;Clinical Trials Design;cloud based;Collaborations;comparison control;Cone;constriction;Consumption;Controlled Clinical Trials;Data;Data Collection;data management;Data Management Resources;Databases;design;Development;Diabetic Retinopathy;DNA Sequence Alteration;Early treatment;efficacy evaluation;Ensure;experience;Eye;gene-targeted therapy;Genotype;Human;Human Resources;Image;improved;Incidence;inherited retinal degeneration;Knowledge;Lead;Leadership;Longitudinal Studies;loss of function;macula;Maintenance;Masks;Measures;meetings;member;Methods;Molecular;Monitor;Multi-Institutional Clinical Trial;Mutation;new technology;Online Systems;Optical Coherence Tomography;Oral;oral supplementation;Outcome;Outcome Measure;oxidative damage;Oxidative Stress;Participant;participant retention;Pathogenicity;Patient Outcomes Assessments;Patients;Performance;Perimetry;Persons;pharmacologic;Phase;photoreceptor degeneration;Placebo Control;Placebos;Preparation;prevent;programs;Protocols documentation;quality assurance;Randomized;randomized placebo controlled trial;randomized trial;Recording of previous events;recruit;Reporting;Research Personnel;Resolution;Retinal Cone;retinal rods;Retinitis Pigmentosa;Role;Safety;Scanning;Secure;Severities;sex;Site Visit;Smoking Status;standard care;Statistical Data Interpretation;Subgroup;success;Symptoms;Testing;Time;treatment arm;Treatment Efficacy;trial design;Vision;Visit;Visual Acuity;Visual disability;Visual Fields;Width

PROJECT_TITLE: NAC Attack, a phase-3, multicenter, randomized, placebo-controlled trial in patients with retinitis pigmentosa