NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Pre-Exposure Prophylaxis (PrEP) for HIV infection is expanding dramatically across sub-Saharan Africa but is unavailable in Liberia, West Africa; however, planning for its introduction has begun. To inform a PrEP roll-out that is preference sensitive, accepted, and sustained for the key population of Liberian adolescent girls and young women, we will undertake a comprehensive assessment of perceptions related to PrEP among these girls and women, as well their male partners and healthcare providers. The results of this investigation will be directly applied to PrEP programming and inform the crafting of intervention strategies that can be piloted and tested so to have maximal opportunity to reduce HIV acquisition by these girls and women.

PI_NAMEs: OGBUAGU, ONYEMA E.;WOHL, DAVID A (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrator;Africa;Africa South of the Sahara;African;AIDS prevention;Attention;Attitude;authority;Behavioral;Clinic;Collaborations;Complex;condoms;Consensus;Country;County;Cross-Sectional Studies;Data;Decision Making;design;Development;Disadvantaged;Eastern Africa;Eligibility Determination;Evaluation;experience;Face;falls;Family Planning;Female Adolescents;Formulation;girls;Goals;Health;Health Personnel;HIV;HIV Infections;HIV vaccine;implementation strategy;infection risk;informant;Injecting drug user;interest;Intervention;intervention mapping;Interview;Investigation;Knowledge;Leadership;Liberia;Liberian;male;Male Circumcision;men;men who have sex with men;Men's Role;Methods;Modality;Modeling;Motivation;Oral;Participant;Perception;Perinatal;Pharmaceutical Preparations;Physicians;Policy Maker;Population;Populations at Risk;pre-exposure prophylaxis;preference;Prevalence;Prevention;Process;Program Development;programs;Provider;Public Health;recruit;Reporting;Reproductive Health Services;Research Infrastructure;Research Methodology;Research Personnel;Respondent;Risk;risk perception;Risk Reduction;Rural;rural area;Scientist;sexual violence;sexually active adolescent;Site;skills;social;Southern Africa;Structure;Techniques;Testing;transgender women;treatment as prevention;uptake;urban area;Vertical Disease Transmission;Vulnerable Populations;willingness;Woman;Work;young woman

PROJECT_TITLE: HIV PrEP Perspectives of Liberian Adolescent Girls and Young Women and their Providers

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Musculoskeletal disorders are some of the most common in the US. Skeletal stem cells harbor massive therapeutic potential, but we know almost nothing about their identity, location, and function within their endogenous environment. Here, we will use state-of-the-art single-cell technologies to precisely transcriptionally and spatially pinpoint these cells and define their cellular contribution to tissue maintenance and repair, facilitating the development of targeted strategies to promote bone regeneration.

PI_NAMEs: LEUCHT, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: adult stem cell;Age;Aging;Automobile Driving;Bar Codes;Bioinformatics;bone;bone fracture repair;bone healing;bone health;Bone Injury;Bone Marrow;Bone Regeneration;bone repair;cell behavior;cell injury;Cell Physiology;Cell Separation;cell type;Cells;Complex;Data;Degenerative polyarthritis;Development;Directories;Disease;Environment;Epiphysial cartilage;Exhibits;experimental study;Exposure to;Femoral Fractures;Fracture;Future;Gene Expression;Gene Expression Profile;Generations;Genetic;Genetic Induction;Genetic Transcription;Harvest;Homeostasis;improved;In Situ;In Vitro;in vivo;Individual;Injury;injury and repair;Internet;Knowledge;Label;Location;Maintenance;Maps;Messenger RNA;Multipotent Stem Cells;Mus;Musculoskeletal Diseases;Natural regeneration;novel;Organ;Osteoporosis;Pathway interactions;Periosteum;Phenotype;Play;Population;Population Dynamics;population health;Probability;progenitor;programs;prospective;protein expression;regenerative approach;Regional Anatomy;repaired;Resolution;response;response to injury;Role;self renewing cell;self-renewal;Signal Pathway;Signal Transduction;single cell technology;single-cell RNA sequencing;Site;skeletal;skeletal injury;skeletal regeneration;skeletal stem cell;Skeleton;stem cell function;stem cell population;stem cell therapy;stem cells;stemness;Structure;Technology;Testing;Therapeutic;Time;Tissues;transcriptome;transcriptomic profiling

PROJECT_TITLE: Unbiased mapping of skeletal stem cell function at single cell resolution in homeostasis and injury.

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: TW

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This training program entitled “Strengthening Research Capacity in Innovative Global Health Technologies for Non-Communicable Diseases in Uganda” will build capacity for Universities and research institutions in Uganda to carry out Biomedical Engineering research. This development is necessary to foster creation of health technologies by Africans for Africans.

PI_NAMEs: ROLLINS, ANDREW MARTIN (contact);SSEKITOLEKO, ROBERT

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Africa South of the Sahara;Applications Grants;Area;Artificial Intelligence;Biocompatible Materials;Biomedical Engineering;biomedical imaging;Biomedical Research;Cardiovascular Diseases;Categories;Chronic;Clinical Investigator;Collaborations;Data Analytics;design;Development;Diagnostic;Disease;Doctor of Philosophy;Drug Delivery Systems;experience;Faculty;global health;Goals;Health Technology;Healthcare;Hematological Disease;Industry;innovation;Institution;Journals;low and middle-income countries;Movement Disorders;Outcome;Output;Peer Review;point-of-care diagnostics;Positioning Attribute;Privatization;programs;Public Health;Publications;Research;Research Personnel;Research Project Grants;Research Support;screening;Students;technological innovation;Technology;Therapeutic;tool;Training;Training Programs;Uganda;Universities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The proposed research is relevant to public health as these studies will generate new fundamental knowledge in head and neck cancer and address the current technical limitations in immunotherapy against head and neck cancer.

PI_NAMEs: LEI, YU LEO;MOON, JAMES J. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Agonist;Animal Model;Animals;anti-PD-1;anti-PD1 therapy;antitumor effect;Benchmarking;Biological Response Modifiers;Breeding;Cancer Patient;Canis familiaris;Cells;Clinical Trials;craniofacial;Crystal Formation;Data;Dental;design;Dinucleoside Phosphates;Disease;Disseminated Malignant Neoplasm;Dose;efficacy evaluation;Engineering;Excision;Formulation;Gene Activation;Genes;Genetic Engineering;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Immune;immune activation;immune checkpoint blockade;Immune response;Immune system;Immunologic Stimulation;immunomodulatory strategy;immunoregulation;Immunotherapy;In Vitro;Injections;Interferons;intravenous administration;Knowledge;Libraries;Lymphoid Tissue;malignant mouth neoplasm;Malignant Neoplasms;Manganese;Mediating;Modeling;mouse model;Mus;nano;nanocrystal;nanoengineering;nanoformulation;nanomaterials;nanoparticle;National Institute of Dental and Craniofacial Research;Nature;Neoplasm Metastasis;new technology;next generation;novel;Oral;particle;particle therapy;Pathway interactions;Patients;Periodicity;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacologic Substance;Property;Public Health;Race;Rattus;Research;Resistance;response;Role;Safety;Sampling;Serum;Spleen;success;System;Therapeutic;Toxic effect;Toxicology;Treatment Efficacy;tumor;Tumor Immunity

PROJECT_TITLE: Engineered Nano-formulations for STING Activation

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Multiple myeloma (MM) is an incurable cancer of plasma cells that is always preceded by an asymptomatic phase comprised of pre-cancerous plasma cells such as in monoclonal gammopathy of undetermined significance (MGUS), or smoldering multiple myeloma (SMM). Given the incurable nature of MM, this project aims to measure the levels of select metabolites in the bone marrow plasma of patients with a spectrum of plasma cell disorders via mass-spectrometry-based approaches so as to distinguish between pre-cancerous and cancerous plasma cells. Ultimately, the knowledge gained from this study will help lower the risk of morbidity and mortality in the general population who remain at risk of developing MM from entities with pre- cancerous plasma cells such as MGUS and SMM; this study will also lay the basis of developing novel strategies in the future to prevent this progression of pre-cancerous plasma cells to MM.

PI_NAMEs: GONSALVES, WILSON  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Amino Acids;Autologous Stem Cell Transplantation;base;biobank;Biological Markers;Bone Diseases;Bone Marrow;Bone Marrow Stem Cell Transplantation;c-myc Genes;Cancerous;Cell Line;Cessation of life;Citric Acid Cycle;Classification;Clinic;Clinical;Development;Diagnostic;diagnostic strategy;Disease;Early treatment;Ensure;experimental study;extracellular;Female;Foundations;Future;General Population;Genomics;Hematology;Human;Image;Immune Evasion;improved;Indolent;Kidney Failure;knock-down;Knowledge;Laboratories;Lytic;male;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Measures;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Monitor;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;mortality;mouse model;Multiple Myeloma;Nature;novel;novel marker;novel strategies;Oncogenic;Organ;overexpression;Pathogenesis;patient derived xenograft model;Patients;peripheral blood;Phase;Plasma;Plasma Cells;premalignant;prevent;Prevention;Prevention strategy;programs;progression risk;Proliferating;Proteins;Quality of life;Relapse;Research;Research Proposals;Resources;response;Risk;Risk Assessment;Risk Estimate;risk stratification;Sampling;Schedule;Small Interfering RNA;Systemic Therapy;Testing;Therapeutic;Time;United States National Institutes of Health;Visit

PROJECT_TITLE: Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The increasing threat of a post-antibiotic era due to the rapid spread of antimicrobial resistance, underlies the need for new antibiotics. Our goal is to develop an antibacterial strategy to impede pathogen metabolic adaptation within the host, through inhibition of a key enzyme in bacterial central metabolism, DXP synthase.

PI_NAMEs: FREEL MEYERS, CAREN L. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Anabolism;analog;Anti-Bacterial Agents;antibiotic resistant infections;Antibiotics;antimicrobial;Antimicrobial Resistance;ascending urinary tract infection;Bacteria;bacterial metabolism;Cell Physiology;Clinical;combat;Combined Modality Therapy;design;Development;Diphosphates;Drug Kinetics;Drug resistance;Drug Targeting;efficacy evaluation;efficacy study;efficacy testing;Environment;Enzymatic Biochemistry;Enzymes;feeding;Goals;Growth;Human;Immune response;in vivo;Infection;inhibitor;inorganic phosphate;isoprenoid;Learning;Metabolic;Metabolic Pathway;Metabolism;Modeling;Mus;mutant;Nutrient;Nutritional;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Permeability;Positioning Attribute;Predisposition;Prevalence;prevent;priority pathogen;Prodrugs;Public Health;Pyridoxal Phosphate;Reaction;Research;Resistance;Role;Serine;Stress;Structure;synergism;targeted agent;targeted treatment;Testing;Thiamine;uptake;Urinary tract;Urinary tract infection;Uropathogen;Vitamins;Work;xylulose-5-phosphate

PROJECT_TITLE: Targeting DXP synthase in bacterial metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(02)M]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Muscular Dystrophy;Nanotechnology;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: CATHOLIC UNIVERSITY OF AMERICA

ORG_STATE: DC

PHR: PROJECT NARRATIVE Using bacteriophage T4 as a model, we will elucidate the structures, functions, and mechanisms by which a viral genome is packaged, stored, and released into a new host in a precisely regulated fashion. We will harness this basic knowledge to create a novel gene therapy vehicle that can deliver a large amount of therapeutic genetic payload into human cells to treat or cure muscular dystrophy, a debilitating disease for which there is currently no cure or effective treatment. This translational research proposal therefore would establish proof of concept for a new and potentially transformative category of bacteriophage-based gene therapeutics to treat/cure many human diseases in the future.

PI_NAMEs: RAO, VENIGALLA B. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Archaeal Viruses;Bacteriophage T4;Bacteriophages;Binding;Biochemistry;Capsid;Categories;Cells;Cessation of life;Complex;conformational conversion;Cryoelectron Microscopy;Data;Data Collection;Defect;Degenerative Disorder;delivery vehicle;density;design;Disease;DNA;DNA Packaging;DNA Structure;Docking;ds-DNA;Duchenne muscular dystrophy;Dystrophin;effective therapy;Experimental Designs;experimental study;extracellular;Future;Gene Delivery;gene therapy;Genes;Genetic;genetic payload;Genome;Head;Human;human disease;improved;In Vitro;in vivo;Individual;Infection;innovation;Interdisciplinary Study;Investigation;Knowledge;Length;Lentivirus;Life Cycle Stages;Ligands;Measures;Modeling;Molecular;Molecular Conformation;Motor;mouse model;Muscle;Muscle Cells;Muscular Dystrophies;muscular dystrophy mouse model;mutant;Myopathy;nanocapsid;nanomachine;nanoparticle;nanoparticle delivery;Nanovirus;Neck;novel;nucleic acid binding protein;Organism;Phase;Physical condensation;Planet Earth;Positioning Attribute;Preparation;pressure;Process;protein complex;Proteins;reconstruction;Regulation;Reporter Genes;Research;Research Proposals;Resolution;seal;Series;Structure;Surface;System;Tail;targeted delivery;Therapeutic;therapeutic gene;Time;Translating;Translational Research;Translations;Tube;vector;Viral;Viral Genome;virology;Virus

PROJECT_TITLE: Structural Mechanisms Of Genome Flow In Bacteriophage T4 And Their Biomedical Applications

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Infectious Diseases;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Compared to age-matched HIV-negative subjects, studies of brain tissues from people living with HIV (PLWH) aged 38-60 years showed increased amyloid plaques and tau hyperphosphorylation. This proposal will study how HIV infection causes/exacerbates AD-like pathology and use extracellular vesicles as nanocarriers to improve drug levels across the BBB to mitigate AD-like pathology in HIV infection.

PI_NAMEs: ISHRAT, TAUHEED ;KUMAR, SANTOSH  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Affect;Age;age related;aged;Aging;aging population;Alzheimer associated neurodegeneration;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Animals;Anti-Retroviral Agents;antioxidant enzyme;antiretroviral therapy;attenuation;Award;Biological Response Modifier Therapy;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain cell;brain tissue;Bypass;Cells;Central Nervous System Diseases;Cessation of life;Cognitive;Curcumin;cytokine;Data;Development;Drug toxicity;Early Onset Alzheimer Disease;efficacy evaluation;Enzymes;experience;extracellular vesicles;Formulation;Goals;HIV;HIV Infections;HIV Seronegativity;Human;hyperphosphorylated tau;improved;In Vitro;in vitro Model;Induced pluripotent stem cell derived neurons;Inflammasome;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Intranasal Administration;Life Expectancy;Macrophage;Measures;Mediating;Memory;Memory impairment;Microglia;Microtubule-Associated Proteins;Modeling;mouse model;Mus;nanocarrier;nanoformulation;Nerve Degeneration;Neurocognition;neuroinflammation;neuron loss;Neurons;novel;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathway interactions;Penetration;Permeability;Persons;Pharmaceutical Preparations;Population;Premature aging syndrome;Principal Investigator;protein biomarkers;Proteins;Regimen;Reporting;Research;Research Personnel;Role;Route;Senile Plaques;Site;Symptoms;Synaptophysin;System;Testing;Therapeutic;Time;Toxic effect;Transgenic Organisms;TXNIP gene;Viral Proteins;Virus;water maze

PROJECT_TITLE: Extracellular vesicles in AD-like pathology in HIV and its potential therapeutics

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative  The proposed project responds to one of the high-priority research topics in NIA, entitled “Common Mechanisms and Interactions Among Neurodegenerative Diseases” (NOT-AG-18-048 for PAR-19-070). Somatodendritic accumulation of tau and further mislocalizaiton to dendritic spines are two common features in AD and multiple ADRDs. We will utilize a newly established mTBI model as a novel tool to clarify the common mechanisms underlying tau mislocalization and associated functional deficits.

PI_NAMEs: EBNER, TIMOTHY J;KOOB, MICHAEL D;LIAO, DEZHI  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Antibodies;Biochemical;Body Composition;Brain;Calcium;CDK5 gene;Cells;Cerebral cortex;Cultured Cells;Dementia;Dendritic Spines;density;Disease;Disease Progression;Early identification;Electrophysiology (science);Event;experimental study;Functional disorder;Genes;glycogen synthase kinase 3 beta;Goals;Hippocampus;Human;human disease;Image;Impairment;Inclusion Bodies;inhibitor;juvenile animal;Knowledge;Label;Mechanics;Mediating;mild traumatic brain injury;Modeling;Modification;Molecular;Morphology;mouse model;Mus;Mutation;neural circuit;Neurodegenerative Disorders;novel;Outcome;Pathogenicity;Pathology;Peptides;PHF-1;Phosphorylation;Phosphorylation Inhibition;Physiological;Play;Polymers;Post-Translational Protein Processing;postsynaptic;prevent;Process;Protein Isoforms;Publishing;Recovery;Research Priority;Role;Series;Severities;Signal Transduction;Slice;Synapses;synaptic function;Synaptic plasticity;System;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tool;Work

PROJECT_TITLE: Using a novel mTBI model to investigate phosphorylation dependent common mechanisms in tauopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Mutations in GDAP1 are associated with the peripheral neuropathy Charcot-Marie-Tooth with underlying con- nections to oxidative stress and mitochondrial dysfunction. Here we propose to determine the structure of GDAP1 bound to 4-hydroxynoneal, which we have discovered as the first biologically binding partner con- nected to oxidative stress. This structure and related biochemistry to determine whether GDAP1 has enzymatic activity, pinpoint the ligand binding site, and reveal conformational changes in GDAP1 concomitant to binding.

PI_NAMEs: VANDEMARK, ANDREW PAUL (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acceleration;Active Sites;adduct;Affect;Affinity;Animal Model;Antioxidants;autosome;Binding;Binding Sites;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biological Assay;Brain;Catalysis;Cell model;Cell Physiology;Cells;Charcot-Marie-Tooth Disease;Complex;Cytoprotection;Data;disease model;Docking;Drug Metabolic Detoxication;Enzymatic Biochemistry;Enzymes;Event;Foundations;Future;GDAP protein;Genes;Genetic Transcription;Glutathione;Glutathione S Transferase A;Glutathione S-Transferase;Goals;Housing;Inherited;interest;Investigation;knock-down;Ligand Binding;Lipid Peroxidation;Lipid Peroxides;Lipids;Location;Malondialdehyde;Measures;Mediating;member;metabolic rate;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Conformation;molecular modeling;molecular pathology;Mutagenesis;mutant;Mutation;Nervous System Disorder;Neurons;Neuropathy;Outer Mitochondrial Membrane;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Peripheral Nervous System Diseases;Persons;Phenotype;Play;Poison;Positioning Attribute;Predisposition;protein protein interaction;Proteins;Resolution;response;Role;Shapes;Signal Transduction;Site;small molecule;Structure;success;System;Therapeutic;Therapeutic Intervention;Time;tool;Tooth Diseases;United States;Visualization;X-Ray Crystallography;Xenobiotics

PROJECT_TITLE: Structure of GDAP1 bound to a product of lipid peroxidation

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_STATE: NC

PHR: Project Narrative/Public Health Relevance The cardiovascular health of Hispanic/Latino sexual and gender minorities has been understudied. The goal of this study is to examine relationships between sexual/gender minority stress, coping, social support, and heart disease - a leading cause of morbidity and mortality among Hispanic/Latinos in the U.S. Findings will inform development of culturally-appropriate interventions to address psychosocial factors that may contribute to cardiovascular health disparities by sexual orientation and gender identity.

PI_NAMEs: PERREIRA, KRISTA M (contact);POTEAT, TONIA C

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Acculturation;Address;Adult;Age;Ancillary Study;Attenuated;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Chicago;cohort;Communities;coping;cost effective;Country;culturally appropriate intervention;Data;Data Analyses;Development;Discrimination;effective intervention;eligible participant;Enrollment;Epidemiologist;Equation;ethnic minority;Ethnic Origin;Ethnic Population;experience;Face;Family;Funding Opportunities;Gender;Gender Identity;gender minority;gender minority status;gender minority stress;Goals;Health;health disparity;health inequalities;Heart Diseases;High Prevalence;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Immigrant;Inequity;innovation;instrument;intersectionality;Intervention;Knowledge;Latino;Latino Population;Length;Lesbian Gay Bisexual Transgender;Linear Regressions;Longitudinal cohort study;Methods;minority stress;Modeling;Modification;Morbidity - disease rate;mortality;multidisciplinary;New York;Parents;Participant;Pathway interactions;Personal Satisfaction;Persons;Population;Psychometrics;Psychosocial Factor;Psychosocial Stress;public health relevance;Publications;Race;racial minority;recruit;Research;Research Support;Residencies;resilience factor;Risk Factors;Risk Reduction;Schedule;Scientist;sex;Sex Orientation;Sexual and Gender Minorities;sexual disparity;sexual minority;Site;social;social stigma;Social support;Stigmatization;Stress;Testing;Time;Visit;young adult;Youth

PROJECT_TITLE: Cardiovascular Health of Sexual and Gender Minorities in the Hispanic Community Health Study/Study of Latinos (SGM HCHS/SOL)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE There is increasing evidence that the progression to psychosis is dynamic and protracted, that cognitive dysfunction is a core feature of schizophrenia with typical maturation throughout adolescence, and that working memory depends partly on widely distributed cortical glutamate- and GABA-mediated neural circuitry. However, connecting the molecular underpinnings of disruptions in this circuitry to in vivo human brain development has been elusive. This integrative project utilizes novel neuroimaging methods and publicly available brain-wide transcriptomic atlases to investigate neurodevelopmental mechanisms of psychosis risk in a prospective longitudinal cohort of youth at clinical high risk for psychosis.

PI_NAMEs: HOFTMAN, GIL D (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Anatomy;Anterior;Area;Atlases;Autopsy;Behavior;behavior measurement;Behavioral;Bioinformatics;Bioinformatics Shared Resource;Brain;career;career development;cell type;Cessation of life;Chronic;Chronic Schizophrenia;Clinical;clinical high risk for psychosis;Cognition;Cognition Disorders;Cognitive;cognitive function;cohort;Complex;Core Facility;Data;Data Set;Development;Dimensions;disability;Disabling;Early Intervention;experience;first episode psychosis;follow-up;functional genomics;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Genes;Genetic;Genomic approach;Genomics;Glutamates;high risk;hippocampal pyramidal neuron;Human;Image;Impaired cognition;Impairment;improved;in vivo;indexing;Individual;Infrastructure;International;Intervention;leadership development;life span;Link;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;longitudinal, prospective study;Magnetic Resonance Imaging;Measures;Mediating;Memory impairment;Mental disorders;Mentors;Methods;Molecular;Molecular Genetics;MRI Scans;National Institute of Mental Health;Neocortex;nervous system development;neural circuit;Neurocognitive;neurodevelopment;neuroimaging;Neurons;Neurosciences;novel;Onset of illness;Outcome;Parvalbumins;Pathway Analysis;Pattern;Performance;Phenotype;Physicians;Population;premature;Prevention;Primates;Process;prospective;Psychoses;psychosis risk;Psychotic Disorders;Research;Research Methodology;Research Personnel;Resources;risk variant;Schizophrenia;schizophrenia risk;Scientist;Short-Term Memory;Standardization;Structure;Synapses;Testing;Thinness;Time;Tissues;Training;Training Support;Transcript;transcriptome;transcriptomics;Work;Youth

PROJECT_TITLE: Imaging transcriptomics across developmental stages of early psychotic illness

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: PROJECT NARRATIVE - Despite aggressive treatment of known risk factors, coronary artery disease (CAD) is still responsible for one in every six deaths in the United States. Evidence from gene expression in diseased human coronary arteries and human genetic studies strongly implicates the gene TWIST1 in CAD. This project will determine the mechanisms by which TWIST1 affects vascular wall biology and thus CAD risk, with the goal of developing novel treatments to reduce the burden of CAD.

PI_NAMEs: WIRKA, ROBERT  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adopted;Affect;aggressive therapy;Aorta;ApoE knockout mouse;Apoptosis;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;Automobile Driving;Award;Bayesian Modeling;Bayesian Prediction;Binding;Biological Models;Biology;blood lipid;Blood Vessels;career development;causal variant;Cell Death;cell dedifferentiation;Cell Differentiation process;Cell Lineage;cell motility;Cell Physiology;cell type;Cells;Cessation of life;Chromatin;conditional knockout;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;Data Set;design;Development;Diabetes Mellitus;differential expression;Differentiation Antigens;differentiation in vitro;Disease;disorder risk;EP300 gene;Fellowship;Fibroblasts;Gene Expression;Genes;Genetic study;Genetic Transcription;genome-wide;Goals;helix-loop-helix protein E12;Human;human data;human disease;Human Genetics;Hypertension;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;in vivo;Injury;insight;Invaded;Knock-out;Knockout Mice;Learning;Lesion;Link;Maps;Medicine;Mentors;migration;Modeling;Molecular;Monitor;Mus;myocardin;Nature;novel;Paper;Pathway Analysis;Pathway interactions;Phenotype;Positioning Attribute;Process;Proliferating;promoter;Regulation;Research;Research Personnel;response;Risk Factors;Role;Rupture;Sampling;Serum Response Factor;Shapes;single-cell RNA sequencing;skills;Smooth Muscle Myocytes;targeted treatment;Time;Training;transcription factor;Transcriptional Regulation;TWIST1 gene;United States;Variant;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: The role of TWIST1 in smooth muscle cells during atherosclerosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Allergies are a risk factor for the development of asthma, and most cases of asthma are allergic in origin, but not all individuals with allergies develop asthma symptoms. Recently it has been recognized that airway lining cells and their interactions with airway immune cells are critical determinants of asthma, but the mechanisms that link changes in the airway lining to airway inflammation in asthmatics are not understood. Our theory is that certain environmental exposures can reprogram airway lining cells and immune cells, causing these cells to respond more robustly upon subsequent exposures; this reprogramming is known as trained immunity, and the objective of this proposal is to determine if trained immunity in the airway lining cells, and immune cells distinguishes whether someone with allergies develops asthma.

PI_NAMEs: MEDOFF, BENJAMIN DAVID (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: airway epithelium;airway inflammation;Allergens;Allergic;Allergic rhinitis;Antioxidants;Asthma;asthmatic;asthmatic airway;Binding Sites;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cell Line;Cell Separation;Cells;Characteristics;Chromatin Structure;Coculture Techniques;Communicable Diseases;curative treatments;Development;Disease;DNA;Economic Burden;effective therapy;Environmental Exposure;Epigenetic Process;Epithelial Cells;Exposure to;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;genomic locus;Glycolysis;Health;Healthcare Systems;Homeostasis;Hypersensitivity;Immune;Immune response;Immunity;Immunologic Memory;Individual;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Link;Lower respiratory tract structure;Lung;Lung Diseases;Maps;Measurement;Measures;Metabolic;Metabolic Pathway;metabolic profile;metabolomics;Modification;Mononuclear;morphogens;new therapeutic target;Nose;pathogen;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Persons;Phagocytes;Phenotype;programs;Publishing;Pyroglyphidae;Reaction;Regulation;Regulator Genes;Respiratory Mucosa;response;Risk;Risk Factors;Role;Sampling;Signal Transduction;single cell ATAC-seq;Spectrometry, Mass, Electrospray Ionization;Structure of mucous membrane of nose;Symptoms;theories;Therapeutic Agents;therapeutic target;Time;Tissue-Specific Gene Expression;Tissues;Training;transcription factor;United States

PROJECT_TITLE: Trained Immunity in the Airway Mucosa Differentiates Asthma from Allergy Alone

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The gut microbiota is an important environmental factor that contributes to the development of obesity, a major health problem linked to cardiovascular disease, metabolic syndrome/diabetes, and some cancers. Building upon prior findings, we will investigate the specific bacterial and host factors that facilitate the uptake and metabolism of fats. Our studies will promote our understanding of how specific gut microbes impact obesity and will identify novel strategies to combat this public health epidemic.

PI_NAMEs: KOO, EUGENE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;Address;Automobile Driving;Bacteria;Biological;Body fat;bZIP Domain;Cardiovascular Diseases;CD14 Antigen;circadian;combat;Data;Dendritic Cells;Diabetes Mellitus;diet-induced obesity;Environmental Risk Factor;Epidemic;Epithelial Cells;Epithelium;Escherichia coli;Fatty acid glycerol esters;Flagellin;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Gnotobiotic;Goals;Gram-Negative Bacteria;gut microbes;gut microbiota;Health;High Fat Diet;Homeostasis;Human;Immune;Immune signaling;insight;Integration Host Factors;Intervention;intestinal epithelium;Intestines;Knowledge;Link;lipid metabolism;Lipids;Lipopolysaccharides;Malignant Neoplasms;Mastigophora;Membrane;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;microbiota;Mus;novel strategies;Obesity;obesity development;Obesity Epidemic;Pathway interactions;Pattern recognition receptor;Public Health;receptor;Regulation;Research;Research Project Grants;Role;Signal Transduction;Small Intestines;sugar;Testing;Therapeutic Intervention;therapeutic target;TLR4 gene;TLR5 gene;transcription factor;uptake;Weight;western diet;Wild Type Mouse;Work

PROJECT_TITLE: Bacterial Regulation of Intestinal Lipid Metabolism


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: ZIONSVILLE

ORG_NAME: WIK DEVICES, LLC

ORG_STATE: IN

PHR: Project Narrative The dramatic rise in drug overdose deaths over the last two decades has been driven, in part, by the proliferation of potent, highly toxic synthetic drugs. Here, we propose developing an improved technology for the detection and identification of these drugs in toxicology cases. This technology will better enable medical examiners, coroners, and public health departments to understand the causative agents in drug overdose cases.

PI_NAMEs: WISEMAN, JUSTIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: addiction;Antibodies;Automation;Autopsy;Blood;Blood Volume;Cessation of life;Chromatography;Clinical Laboratory Information Systems;Collection;commercialization;Communities;Computer software;Consumption;Coroners and Medical Examiners;cost;Data;Data Analyses;Derivation procedure;design;Detection;detection limit;Development;Devices;Drops;Drug Screening;Drug Targeting;Effectiveness;fentanyl analog;flexibility;Forensic Medicine;Goals;Hand;High Pressure Liquid Chromatography;Immunoassay;improved;instrument;instrumentation;Investigation;ion source;ionization;Laboratories;liquid chromatography mass spectrometry;Manuals;Marketing;Mass Fragmentography;mass spectrometer;Mass Spectrum Analysis;Methods;National Institute of Drug Abuse;novel;Opioid;Outcome;Overdose;overdose death;Paper;Paper Chromatography;Performance;performance tests;Pharmaceutical Preparations;Phase;Plasma;Preparation;Procedures;Proliferating;prototype;Public Health;Reaction;research and development;Research Support;Resolution;Running;sample collection;Sampling;Scanning;screening;Sensitivity and Specificity;SNAPIN gene;software development;Solid;Solvents;Source;Specificity;Spottings;Standardization;Structure;Surveys;synthetic cannabinoid;synthetic drug;System;Techniques;Technology;Testing;Time;Toxic effect;Toxicology;United States National Institutes of Health;virtual;wasting;Whole Blood

PROJECT_TITLE: All-in-one Device for Forensic Toxicology Drug Screening


ORG_CITY: UTICA

ORG_NAME: MASONIC MEDICAL RESEARCH LABORATORY, INC

PHR: NARRATIVE Standard of care for systemic lupus erythematosus involves the use of non-specific immunosuppressants or anti- inflammatory drugs to control symptoms. Unfortunately, the efficacy of these conventional therapies is substandard, and continuous use has the potential to cause serious side effect. In this proposal, we will investigate a novel paradigm for the treatment of lupus, whereby modulators of the protein tyrosine phosphatase SHP-2 are delivered directly to the spleen with the goal of eliciting a systemic therapeutic effect.

PI_NAMEs: MCCARTHY, JASON R. (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Active Sites;adaptive immune response;Anti-Inflammatory Agents;Antibodies;Antigen-Presenting Cells;Antigens;Antisense Oligonucleotides;Apoptotic;Autoantibodies;Autoantigens;Autoimmune Diseases;B-Lymphocytes;Biological Assay;Biological Response Modifiers;Biomimetics;Blood Platelets;Case Study;Cell membrane;cell type;Cells;Circulation;Clonal Expansion;cohort;conventional therapy;Crescentic Glomerulonephritis;curative treatments;cytokine;Dendritic Cells;design;Disease;Disease remission;Dose;Drug Delivery Systems;drug release profile;Engineering;Erythrocytes;Excision;Exhibits;experimental study;extend lifespan;follow-up;Functional disorder;Generations;Goals;HDAC4 gene;Heart;Hematology;Histologic;Histone Deacetylase Inhibitor;Human;IL17 gene;Immune;Immune response;Immune Tolerance;immunoregulation;Immunosuppressive Agents;improved;In Vitro;Incidence;indexing;Infarction;Inflammatory;inhibitor;Innate Immune Response;Lipids;loss of function;Lupus;lupus prone mice;Lymphocyte;Macrophage;Measures;Mediating;mimetics;Molecular;monocyte;mouse model;multiorgan damage;Mus;Myocardial Infarction;nanomaterials;nanoparticle;Nature;Necrosis;Nephritis;novel;novel therapeutics;Oligonucleotides;Organ;organ injury;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphatidylserines;Phosphoric Monoester Hydrolases;Physiological;Platelet Count measurement;Play;Population;Process;Production;protein phosphatase inhibitor-2;Protein Tyrosine Phosphatase;RNA Interference;Role;Safety;secondary lymphoid organ;senescence;Severities;side effect;Signaling Protein;skin lesion;small molecule;small molecule inhibitor;Source;Specificity;Spleen;Splenectomy;Splenic Tissue;Splenomegaly;src Homology Region 2 Domain;standard of care;Structure;Symptoms;System;Systemic Lupus Erythematosus;Systemic Therapy;T cell response;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Thrombocytopenia;tissue injury;trafficking;Treatment Efficacy;uptake;zeta potential

PROJECT_TITLE: Splenic Modulation of SHP-2 Activity as a Therapeutic Option for Systemic Lupus Erythematosus


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Hematology;Lung;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The proposed work will further develop and advance sensitive, non-invasive, non-ionizing, three-dimensional imaging methods to measure regional lung function using inhaled hyperpolarized xenon-129 gas. Specifically we focus on the evaluation of toddlers and preschool-age hematopoietic stem-cell transplant (HSCT) patients who are at significant, elevated risk for deadly lung complications post-HSCT but are too young to perform clinical lung-function testing. 129Xe MRI will address the unmet need for better diagnostic strategies for early lung- function abnormalities in very young children, leading to personalized clinical management, early intervention, and ultimately, improved patient outcomes across the entire spectrum of pediatric lung conditions.

PI_NAMEs: WALKUP, LAURA LEE (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: 18 year old;5 year old;Age;Awareness;Black Box;Blood Vessels;Cessation of life;Characteristics;chest computed tomography;Child;Childhood;Childhood Injury;Clinical;clinical application;clinical care;Clinical Management;clinical risk;Contrast Media;Data;Defect;Diagnosis;Diagnostic;diagnostic strategy;Diffusion;Disease;Early Diagnosis;Early Intervention;Ensure;Erythrocytes;Etiology;Evaluation;experience;Functional disorder;Gases;Goals;Hematopoietic Stem Cell Transplantation;Heterogeneity;Image;imaging modality;Imaging Techniques;Impairment;improved;improved outcome;Individual;Inhalation;innovation;interstitial;Lung;Lung Diseases;lung injury;Lung Transplantation;Magnetic Resonance Imaging;Malignant - descriptor;Measures;microvascular pathology;Monitor;Morbidity - disease rate;mortality;MRI Scans;Neonatal;neonate;Non-Malignant;novel;Nursery Schools;Obstruction;Outcome;Patient-Focused Outcomes;Patients;personalized management;personalized therapeutic;Phenotype;Physiological;Population;Process;pulmonary agents;pulmonary function;pulmonary function decline;Pulmonary function tests;Research;Resolution;Risk;risk stratification;Sampling;Scanning;School-Age Population;Sedation procedure;Signal Transduction;Source;Spirometry;success;targeted treatment;Techniques;Testing;Therapeutic;Three-Dimensional Imaging;Tissues;Toddler;Translating;Transplant Recipients;treatment response;vascular abnormality;vascular factor;ventilation;volunteer;Work;X-Ray Computed Tomography;Xenon

PROJECT_TITLE: Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: During aging and diseases of aging, the ability to use memory to guide behavior becomes impaired, often causing severe reduction in independence and quality of life. Our understanding of the neural processes that allow memories to shape ongoing behavior is limited, and we know even less about how they change over aging. This project will use large-scale multi-electrode hippocampal recordings and real-time manipulation of memory-related neural processes in order to understand how memories are used to guide behavior in both young adult and aged subjects and to develop methods to directly counter age-related dysfunction of memory processes.

PI_NAMEs: GILLESPIE, ANNA KATHLEEN (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Age;age related;age related changes;Age-associated memory impairment;aged;Aging;aging related disease;Algorithms;animal old age;Animals;awake;Award;Behavior;Behavioral;behavioral impairment;Behavioral Paradigm;Brain;Cognition;cohort;Decision Making;Detection;Deterioration;Development;Electrodes;Event;experience;experimental study;extracellular;Faculty;Feedback;Foundations;Frequencies;Functional disorder;Future;Hippocampus;Human;Impairment;improved;Institution;juvenile animal;Learning;Link;Location;Measures;Memory;memory consolidation;Memory impairment;Memory Loss;memory process;memory retrieval;Mentors;Methods;multimodality;neural;neurofeedback;novel therapeutic intervention;Operant Conditioning;Performance;Phase;Play;Positioning Attribute;prevent;Process;prospective;Quality of life;Reporting;Resolution;Retrieval;Rodent;Rodent Model;Role;Shapes;Sleep;Slow-Wave Sleep;Space Models;spatial memory;Statistical Algorithm;Symptoms;Task Performances;Techniques;Testing;Time;tool;young adult

PROJECT_TITLE: Real-time manipulations to understand and improve memory processes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT RELEVANCE NARRATIVE  Burkholderia cepacia complex (Bcc), consisting of more than 20 species of Gram-negative bacteria, poses a major threat to public health and causes severe opportunistic lung infections in up to 5% of cystic fibrosis (CF) patients worldwide. The colonization of Bcc poses a substantial threat to CF patients marked by rapid heath decline and difficult treatment due to their intrinsic resistance to antibiotics and antimicrobial peptides. Our research proposes to investigate the novel attachment mechanism involved in the bacterial surface protein Sap1Bcc and its host cell receptor GPNMB, which is fundamental to the understanding of Bcc pathogenesis and will eventually aid in the improvement of therapeutic strategies.

PI_NAMEs: HOANG, TUNG T (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Affinity;Alzheimer's Disease;Animal Model;anti-microbial peptide;Antibiotic Resistance;Bacteria;Bacterial Attachment Site;Binding;Burkholderia;Burkholderia cepacia;Burkholderia cepacia complex;Burkholderia Infections;Burkholderia pseudomallei;Cell Culture Techniques;Cell Line;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cell-Matrix Junction;Cells;chronic infection;Clinical;clinically relevant;Complex;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Death Rate;Disease;Disease Outbreaks;Disease Progression;Drug Targeting;effective therapy;emerging pathogen;Enzyme-Linked Immunosorbent Assay;Future;Glycoproteins;Goals;Gram-Negative Bacteria;Homologous Gene;Hypothetical Protein;immunosuppressed;improved;In Vitro;in vivo;Inbred BALB C Mice;Individual;Infection;Invaded;Knock-out;Knowledge;Life;Lung infections;Malignant Neoplasms;Melanoma;member;Membrane Proteins;Modeling;Molecular;Mus;Nonmetastatic;Nosocomial Infections;novel;novel vaccines;overexpression;pathogen;Pathogenesis;pathogenic bacteria;Persons;Pneumonia;prevent;Prevention;Process;Prokaryotic Cells;protein B;Proteins;Public Health;receptor;Receptor Cell;Research;Role;SH2D1A gene;Surface;Syndrome;Technology;Therapeutic;transcriptome;Treatment outcome;treatment strategy;United States;vaccine development;Vaccines;Virulence;Virulence Factors;Virus

PROJECT_TITLE: A novel attachment mechanism for Burkholderia cepacia complex

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Digestive Diseases;Hematology;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: NEW YORK

ORG_NAME: CERAMEDIX HOLDING, LLC

PHR: Nuclear terrorism and the impact of extreme weather events on nuclear facilities have increased the risk of widespread radiation exposure and mass casualties. Ceramedix Holding LLC is developing therapies that treat radiation illnesses and are suitable in mass casualty settings. We will perform pharmacology and CMC development to accelerate IND submission.

PI_NAMEs: VID, GALINA  (contact)

PROGRAM_OFFICER_NAME: DICARLO-COHEN, ANDREA L

PROJECT_TERMS: Acceleration;Antibodies;Apoptosis;assay development;Binding;Biological Assay;Biology;Biotechnology;Cell Death;cell injury;Cell membrane;Cells;Ceramide Signaling Pathway;Ceramides;Cessation of life;clinical development;comparative;Data;Development;Devices;diabetic;Diabetic Nephropathy;Diabetic Retinopathy;dirty bomb;Disease;Dose;drug development;drug discovery;efficacy evaluation;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Event;extreme weather;FDA approved;Fibrosis;Fukushima;Funding;gastrointestinal;Gastrointestinal tract structure;Goals;Government;Hematopoietic;Human;Human Resources;Immunoglobulin Fragments;improved;In Vitro;in vitro Assay;in vivo;Intellectual Property;irradiation;Japan;lead candidate;leadership development;leukemia;Licensing;Lipid Biochemistry;Lung;lung injury;macular edema;mass casualty;Medical;medical countermeasure;Memorial Sloan-Kettering Cancer Center;Methodology;Modeling;monomer;Morbidity - disease rate;mortality;Mus;National Security;nonhuman primate;Nuclear;Nuclear Accidents;Organ;Pathway interactions;Pegfilgrastim;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phase;pre-clinical;Pre-Clinical Model;preclinical development;prevent;protective pathway;Radiation;Radiation Dose Unit;Radiation exposure;Radiation Injuries;Radiation Syndromes;Radiation Toxicity;Radiology Specialty;research clinical testing;response;Risk;Schedule;Seasons;Signal Transduction;Small Business Innovation Research Grant;Stimulus;subcutaneous;Syndrome;synergism;Terrorism;Therapeutic;therapeutic candidate;therapy development;Time;Validation;Work

PROJECT_TITLE: Non-Clinical Pharmacology of CX-01


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Pain Research;Sleep Research

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Symptoms of insomnia are common in people with Crohn’s disease and may predict greater likelihood of disease flare, surgery, hospitalization, and reduced quality of life. Cognitive Behavioral Therapy for Insomnia (CBT-I) is highly effective for treating insomnia and may reduce chronic pain and inflammation, both significant problems in Crohn’s disease. In the proposed mixed methods study, we seek to investigate the feasibility, acceptability, and impact CBT-I in 60 adults with Crohn’s disease in order to improve understanding of treatment of insomnia, pain, and inflammation and inform the development of a rigorous NIH R01 application.

PI_NAMEs: SALWEN-DEREMER, JESSICA K (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Abdominal Pain;acceptability and feasibility;active control;Address;Adult;Affect;Behavior;Behavior Therapy;behavioral clinical trial;Biological Markers;Body Weight decreased;burden of illness;C-reactive protein;career development;Chronic;chronic pain;Clinical Trials;Cognitive Therapy;comorbidity;comparison control;cost;Crohn's disease;Data;Data Analyses;Defecation;Development;Diarrhea;Disease;Disease remission;Effectiveness;effectiveness evaluation;Etiology;experience;Eye;Fatigue;feasibility trial;Fecal Incontinence;Feces;Flare;Frequencies;Fright;Functional disorder;Funding;gastrointestinal symptom;Gastrointestinal tract structure;Generations;Goals;Health;Hospitalization;Immune;improved;improvement on sleep;indexing;Individual;Inflammation;Inflammatory;interest;Intervention;Interview;Intestines;Investigation;Joints;Lead;Leukocyte L1 Antigen Complex;Link;Mediating;medical schools;Mentorship;Methodology;Methods;Moods;Operative Surgical Procedures;Outcome;Pain;Participant;Patient Care;Patient Self-Report;Pattern;Persons;Pharmacotherapy;physical conditioning;poor sleep;Population;post intervention;primary outcome;Procedures;prospective;Quality of life;Questionnaires;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Infrastructure;Research Methodology;Research Project Grants;secondary outcome;Severities;Severity of illness;side effect;Skin;Sleep;Sleep Disorders;sleep onset;sleep pattern;Sleeplessness;social health determinants;Structure;Subgroup;symposium;Symptoms;telehealth;Testing;Time;Training;Training Programs;treatment response;United States National Institutes of Health;Visit

PROJECT_TITLE: A Fully Remote Pilot Randomized Controlled Trial to Investigate the Impact of Insomnia Treatment on Crohn’s disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Poor sense of smell affects about 25% of older US adults. The proposed study will generate novel and important knowledge on the potential profound health implications of poor olfaction in older adults, including but not limited to dementia and Parkinson’s disease. This knowledge will benefit public health by advancing our understanding of how a poor sense of smell may affect the health of older adults, and thus improve their health, quality of life, and longevity.

PI_NAMEs: CHEN, HONGLEI  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Adult;Affect;African American population;Age;age acceleration;age related biomarkers;age related decline;Aging;Alzheimer's Disease;Atherosclerosis Risk in Communities;Behavior;biracial;Black Populations;Body Composition;Body Weight decreased;cardiovascular disorder risk;Chronic;Chronic Disease;Chronology;Clinical;Clinical Management;clinically significant;Cognitive;cognitive function;cohort;Collaborations;Collection;Communities;comorbidity;Data;Data Collection;Dementia;Detection;Deterioration;Diabetes Mellitus;Diet;Disease;Elderly;Epidemiologist;epigenetic marker;Excess Mortality;Exhibits;experience;frailty;functional decline;Health;health assessment;health data;human old age (65+);improved;Individual;innovation;Institution;Intervention Trial;Knowledge;Life;Link;Longevity;Lung;men;mental function;Monitor;Moods;mortality;multidisciplinary;Neurocognitive;Neurodegenerative Disorders;novel;nutrition;older adult;Olfactory dysfunction;Outcome;Parkinson Disease;Participant;Performance;Physiological;Pneumonia;poor health outcome;Population;Populations at Risk;Predisposition;Prevalence;Productivity;prospective;Prospective Studies;Psyche structure;Public Health;public health relevance;Publishing;Quality of life;Race;rate of aging;Reproducibility;Research;Research Design;Research Personnel;Respiratory Disease;Risk;Safety;Sample Size;Sensory impairment;sex;Smell Perception;Solid;Source;Statistical Data Interpretation;stressor;Symptoms;System;Testing;validation studies;Visit;Woman

PROJECT_TITLE: Poor sense of smell and the health of older adults

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Opioid use disorders present a devastating and major public health concern and are marked by behaviors such as a compulsive desire to use opioids despite negative consequences, severe withdrawal symptoms upon drug abstinence and incredibly high relapse rates. More knowledge is needed about the specific brain circuits and cell types that express the mu opioid receptor through which opioids act. This proposal will investigate the properties of such cells and circuits, with the ultimate goal of building upon these findings to uncover new therapies to mitigate opioid abuse and relapse.

PI_NAMEs: TUCCIARONE, JASON M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;American;Analgesics;Axon;Behavior;Behavioral;behavioral economic analysis;Biological Assay;Brain;Calcium;cell type;Cells;Characteristics;Clinical Research;combat;conditioned place preference;Consumption;Corpus striatum structure;COVID-19 pandemic;Depressed mood;Desire for food;Dissection;Dopamine Receptor;Dorsal;drug abstinence;drug reward;Extinction;Fiber;Foundations;Gene Expression;Genetic;genetic manipulation;Goals;Health;Immediate-Early Genes;insight;Intervention;Intoxication;Island;Knowledge;Label;lens;Maintenance;Measures;Mediator;medication-assisted treatment;Monitor;motivated behavior;mouse genetics;mu opioid receptors;Naloxone;Negative Reinforcements;Negative Valence;Nervous System;Neuroanatomy;Neurobiology;neuroimaging;Neurons;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid mortality;opioid overdose;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Optics;optogenetics;Output;Pathologic;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Population;Positive Reinforcements;Positive Valence;Pre-Clinical Model;preclinical study;prodynorphin;Property;Psychological reinforcement;Public Health;rabies viral tracing;receptor expression;recruit;Relapse;response;Rewards;Role;Self Administration;Source;striosome;Substance Use Disorder;Techniques;Training;Ventral Striatum;Viral;Virus;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: A patch circuit dissection of opioid addiction


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The Hedgehog (Hh) pathway plays a central role in directing cellular proliferation, differentiation, and patterning choices in the context of embryonic development, tissue regeneration, and cancer. The research proposed here will identify new regulatory modules of the Hh pathway and define the mechanisms that alter target cell sensitivity to Hh ligands. Advances in this area will provide a more comprehensive understanding the mechanisms that regulate Hh signaling and identify new strategies for future pathway targeted therapies.

PI_NAMEs: KONG, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Affect;Animals;Area;Attenuated;Award;Biochemical;Biochemistry;Biological Assay;Biological Process;Biology;bone;Brain;Cancer Biology;Cell Differentiation process;Cell Proliferation;Cell surface;Cells;Cilia;Complex;Computational Biology;Congenital Abnormality;congenital anomaly;CRISPR screen;CRISPR/Cas technology;Cues;Defect;Degenerative Disorder;Development;Developmental Biology;differentiation in vitro;Disease;Embryo;Embryonic Development;Erinaceidae;Event;extracellular;Fibroblasts;Future;gene function;Genes;genome-wide;Goals;graduate school;Heart;Human;Impairment;Integral Membrane Protein;Lead;Learning;Ligands;Limb structure;loss of function;Lung;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;member;Membrane;Mentors;Mentorship;Microscopy;Microtubules;Minor;Molecular;morphogens;mouse genetics;Mus;mutant;Mutation;Natural regeneration;neglect;nerve stem cell;Neurons;novel;Outcome;Pathway interactions;Pattern;Phase;Physiological;Play;post-doctoral training;Postdoctoral Fellow;programs;Proliferating;Protein Biochemistry;protein transport;Proteins;Regulation;Research;Resources;response;Role;Set protein;Signal Transduction;skills;Spinal Cord;targeted treatment;Testing;Time;tissue regeneration;Tissues;trafficking;Training;Transducers;Translating;ubiquitin-protein ligase;Ubiquitination;Universities;Work

PROJECT_TITLE: Molecular mechanisms that regulate target cell sensitivity to Hedgehog morphogens


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE These exploratory studies could lead to the development of a mass producible device that uses a simple blood sample to identify people most suited for clinical trials of Alzheimer’s disease therapeutics. The same device could also be used for monitoring disease progression throughout the trial.

PI_NAMEs: COUGHLAN, MARK  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Affect;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Area;Biochemical;Biological Markers;biomarker panel;Biophysics;Blood specimen;Brain scan;Calibration;Cancer Detection;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical Trials;Cognition Disorders;Cognitive;cohort;Consumption;cost;cost effective;Dementia;design;detection platform;Development;Devices;Disease;Disease Progression;DNA Folding;drug action;drug candidate;Drug Targeting;Enrollment;experimental study;fabrication;Future;Individual;Investigation;Lab On A Chip;Label;Light;Light-Scattering Spectroscopy;manufacture;Mass Spectrum Analysis;Measures;miniaturize;misfolded protein;Modality;Modeling;Molecular Conformation;Monitor;nanophotonic;nanoscale;Nervous System Disorder;Neurodegenerative Disorders;novel;novel marker;Optics;Parkinson Disease;Participant;Performance;Persons;photonics;Plasma;polymerization;Polymers;Positron-Emission Tomography;Property;protein structure;Proteins;prototype;Raman Spectrum Analysis;Reproducibility;Research;Sampling;screening;skills;Spinal Puncture;Standardization;stem cell differentiation;Structure;System;targeted biomarker;Techniques;Testing;therapeutic development;Time;two-photon;Validation;waveguide

PROJECT_TITLE: A lab-on-a-chip device for measuring multiple biochemical and biophysical biomarkers of Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Global climate change is expected to have significant consequences for the health and wellbeing of affected populations, especially for individuals who are older and (or) economically marginalized. We use demographic and health surveys from Indonesia and Mexico, combined with high-resolution climate records, to measure the effects of climate exposures during early childhood, adolescence, and early adulthood on health, economic, and migration outcomes in older adulthood.

PI_NAMEs: THIEDE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adolescence;Adult;Adult women;Affect;Age;aged;aging population;Area;Attention;Behavior;Birth;Blood Pressure;Body mass index;Characteristics;Child;Climate;climate change;climate data;climate impact;climate variability;climate-related exposures;climate-related health;Consumption;Country;critical period;Data;Data Sources;Demographic and Health Surveys;Development;Dimensions;disadvantaged women;early childhood;early life exposure;Economic Conditions;Economics;Education;emerging adult;Epidemiology;expectation;Expenditure;Exposure to;Family Life Surveys;food insecurity;Future;Health;Hemoglobin;Human Development;Income;Individual;Indonesia;Inequality;insight;interest;late life;Life;Life Cycle Stages;Link;Literature;low and middle-income countries;marginalization;Measurement;Measures;Mexican;Mexico;migration;Modeling;mortality;older adult;Older Population;Outcome;Pattern;Personal Satisfaction;Phase;Population;population health;Poverty;Precipitation;Process;Recording of previous events;Records;Recurrence;Research;residence;Resolution;Rural;rural area;Sampling;Series;Severities;sex;Shock;social;socioeconomics;Statistical Data Interpretation;Temperature;Testing;Time;Underweight;urban area;Vulnerable Populations;Work

PROJECT_TITLE: Cumulative Demographic and Health Effects of Climate Exposures

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Autoimmune Disease;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Genetics;Hypertension;Kidney Disease

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Kidney inflammatory cell infiltration contributes to Diabetic kidney disease, but specific subpopulations have not been identified, and the crosstalk signaling with specific kidney cells is less clear. We will identify subpopulation of inflammatory cells with novel methods and study whether Th17 cells and IL17 activate the renin angiotensin system by acting directly on JG cells to induce glomerular and kidney injury.

PI_NAMEs: MENDEZ, MARIELA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Affect;Albuminuria;Area;arteriole;Blood Pressure;Cell Separation;cell type;Cells;Combined Modality Therapy;Cytokine Signaling;Cytometry;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;diabetic patient;Fibrosis;Genes;Glucose;Grant;Histologic;Homing;Hyperglycemia;Hypertension;IL17 gene;Image;Image Cytometry;improved;Inactive Renin;Infiltration;Inflammatory;Inflammatory Infiltrate;Injury to Kidney;Insulin-Dependent Diabetes Mellitus;Interleukin Receptor;Interleukins;Juxtaglomerular Apparatus;Juxtaglomerular Cell;Kidney;kidney cell;kidney cortex;Kidney Diseases;kidney fibrosis;LoxP-flanked allele;Lymphocyte;Methods;Mononuclear;Mus;novel;Organ;Pathogenicity;Pathway interactions;Patients;Phenotype;Plasma;Population;prevent;receptor;renal damage;Renal function;Renin;Renin-Angiotensin System;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;T cell infiltration;T-Lymphocyte;transcriptome sequencing;Transgenic Organisms;type I diabetic

PROJECT_TITLE: Novel mechanism of activation of the Renin-Angiotensin-System by inflammatory cells in diabetic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Osteoporosis

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The overall goal of this project to understand the unique behavior of jawbones, based on our preliminary data demonstrating that osteoblasts from jawbone respond to Bone morphogenic protein (BMP) signaling and mechanical stress very differently from osteoblasts from long bone. We will identify “crossover” points of these pathways using a newly emerged proximity labeling technology to mechanistically connect growth factor signaling and mechanosensing signaling pathway unique in the jawbone. Taken together, completion of the proposed study will provide novel aspects of molecular insights to understand skeletal homeostasis in jawbone and thus provide better ideas for physical and pharmacologic interventions towards pathological conditions specific for jawbone, such as osteonecrosis in the jaw and alveolar ridge augmentation by BMPs upon dental implant.

PI_NAMEs: MISHINA, YUJI  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Alveolar Ridge Augmentation;Anatomy;ascorbate;Behavior;Binding Proteins;Biotinylation;Bite Force;BMPR1A gene;bone;bone cell;bone health;bone loss;bone mass;Bone Morphogenetic Proteins;Bone necrosis;bone quality;Bone Resorption;Bone Transplantation;bone turnover;Breathing;Cell Culture System;cell growth regulation;Cells;Cephalic;clinical application;clinically relevant;Collagen;Complex;craniofacial bone;cranium;crosslink;Data;Data Set;Defect;Degenerative Disorder;Dental Implants;Dentistry;Development;Eating;Engineering;Environment;Exercise;Exhibits;experimental study;Expressed Emotion;Future;Genes;Genotype;Goals;Growth;Growth Factor;Health;Homeostasis;in vivo;individualized medicine;insight;Intervention;intramembranous bone formation;Investigation;Jaw;Knock-out;Knowledge;knowledge base;Label;Ligands;Location;long bone;loss of function;Mandible;Mastication;mechanical force;mechanical load;mechanical properties;mechanical stimulus;Mechanical Stress;Mechanics;mechanotransduction;Mesoderm;migration;Molecular;Mus;mutant mouse model;Mutant Strains Mice;Neural Crest Cell;novel;Osteoblasts;osteoclastogenesis;Osteogenesis;Pathologic;Pathway interactions;Peroxidases;pharmacologic;Phenotype;Physiologic Ossification;Play;Prosthesis;Proteins;Proteomics;Quality of life;receptor;recombinant human bone morphogenetic protein-2;reconstruction;Reporting;Research;Resolution;response;rib bone structure;RNA Sequences;Role;Signal Pathway;Signal Transduction;Signaling Protein;Sinus;skeletal;Skeletal bone;skeletal disorder;Skeletal system;Skeleton;Soft Diet;Spinal Fusion;substantia spongiosa;synergism;Technology;tibia;Time;Tooth structure;transcriptome;treadmill;Treatment Protocols;Validation;Vertebral column

PROJECT_TITLE: Jawbone is unique: differential responses to growth factor signaling and mechanical loading

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Standard behavioral treatment for adolescent obesity produces minimal weight loss, indicating it misses a key maintaining factor. One possible maintaining factor for adolescent obesity is sleep disturbance, which drives poor decision-making and subsequently, problematic eating behavior/weight gain. Our study aims to integrate a behavioral sleep treatment with lifestyle modification for adolescent obesity to improve outcomes.

PI_NAMEs: MANASSE, STEPHANIE  (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;Aftercare;Age;Award;Behavior;Behavior Therapy;Behavioral;behavioral sleep intervention;Binge Eating;Body mass index;Body Weight decreased;Cardiovascular Diseases;career;Case Series;Childhood;circadian;Cognitive;Data;Decision Making;design;Diabetes Mellitus;Diagnostic;diaries;Dietary intake;Eating;Eating Behavior;efficacy testing;emotion regulation;Emotional;Emotions;Energy Intake;evidence base;excessive weight gain;Feedback;Food;Future;Goals;Hyperphagia;improved;improved outcome;improvement on sleep;Intervention;Life Style Modification;Link;Literature;Malignant Neoplasms;Manuals;Mentored Patient-Oriented Research Career Development Award;Meta-Analysis;Methods;Modality;Modeling;negative affect;neural;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;obesity risk;obesity treatment;Outcome;outcome prediction;Overweight;Parents;Participant;Pathway interactions;Phase;Prevalence;programs;prospective;psychologic;Public Health;recruit;Research;response;Rewards;Risk;Schedule;Schools;Sleep;Sleep disturbances;social;Stimulus;Testing;tv watching;United States;Weight;Weight Gain;weight loss intervention;Work;Youth

PROJECT_TITLE: Improving sleep as a method for enhancing decision-making and reducing problematic eating behaviors in adolescents with obesity

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Asthma;Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Intellectual and Developmental Disabilities (IDD);Lung;Mental Health;Neurosciences;Pediatric

ORG_CITY: SOUTH HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MOUNT HOLYOKE COLLEGE

PHR: PROJECT NARRATIVE Allergies, asthma, and other immune hypersensitivities during pregnancy are thought to contribute to the cause and severity of neurodevelopmental disorders. This project uses a mouse model of allergic asthma to determine whether maternal interleukin-4, an important immune signal in allergic responses, impacts offspring brain and behavior differences.

PI_NAMEs: SCHWARTZER, JARED  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adult;Adult Children;Allergic;allergic response;antagonist;Asthma;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;Autoimmune Diseases;Automobile Driving;Behavior;Behavior assessment;behavior measurement;behavior prediction;Behavioral;behavioral impairment;behavioral outcome;behavioral phenotyping;Biological;Biological Markers;Brain;career;case control;Characteristics;Child;Chronic Disease;Clinical Research;cytokine;Data;Development;Diagnosis;Disease;Dose;Economically Deprived Population;efficacy evaluation;Encephalitis;Environment;Environmental Risk Factor;epidemiology study;Equilibrium;Ethnic Origin;Exhibits;experience;experimental study;Extrinsic asthma;Family history of;fetal;Fetal Development;Future;gender diverse;High Prevalence;Human;Hypersensitivity;Immune;Immune signaling;Immune System Diseases;improved;Incidence;innovation;Institution;Interleukin 4 Receptor;Interleukin-4;Interleukins;late life;Link;maternal immune system;Measures;Mothers;mouse model;Mus;National Institute of Mental Health;neurobehavioral;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neurodevelopmental effect;Neuroimmune;neuropsychiatric disorder;offspring;Peripheral;Pharmaceutical Preparations;pharmacologic;Play;Populations at Risk;post pregnancy;Pregnancy;prevent;Public Health;racial minority;repetitive behavior;Reporting;Research;Research Domain Criteria;Risk;Role;Safety;Sampling;Science;Severities;Signal Transduction;Social Behavior;Social Interaction;socioeconomic disadvantage;Statistical Models;Students;Testing;Therapeutic Intervention;tool;undergraduate research;Underrepresented Populations;United States;urban setting;Variant

PROJECT_TITLE: Maternal Interleukin-4 and allergic asthma in mouse offspring behavioral deficits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-R (86)]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  Disruption of mechanisms regulating emergency myelopoiesis (EM) pathways, in particular in response to inflammatory triggers, has significant detrimental consequences for the organism across many life stages and disease contexts, making EM pathways prime mechanisms to target for translational applications. A major barrier in turning these findings into therapeutic strategies is our lack of understanding of EM pathways contributions to many pathophysiological situations. Our research project seeks to remove this roadblock by investigating the contribution of EM pathways to adaptive and maladaptive myelopoiesis associated with immune deregulations, solid cancers, and blood disorders.

PI_NAMEs: PASSEGUE, EMMANUELLE  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Aging;Biology;Blood;Bone Marrow;cell behavior;Cells;Chronic;Development;Disease;Emergency Situation;Epigenetic Process;fighting;Genetic Transcription;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;Homeostasis;Human;imaging approach;Immune;Immune response;Immunity;Inflammation;Inflammatory;leukemia;Life;Malignant Neoplasms;Metabolic;Modeling;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;National Heart, Lung, and Blood Institute;Natural regeneration;novel;Organism;Pathway interactions;Population;Production;Property;regenerative;Regulation;Research Project Grants;response;self-renewal;Signal Transduction;Solid;System;Therapeutic;Training;Translating;translational applications;tumor-immune system interactions;Work

PROJECT_TITLE: Emergency Myelopoiesis in the Control of Blood Production

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


NIH_SPENDING_CATS: Bioengineering;Kidney Disease;Nutrition

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE BOYD-SHIWARSKI Studies have shown a significant decline in dietary potassium intake over the past several decades and estimate that 98% of the US population is now deficient in dietary potassium—this deficiency has been attributed to the rise in processed food, decreased intake of fruits and vegetables, and the agriculture soil depletion of potassium. There is an urgent and compelling need to study the health consequences of inadequate potassium intake, specifically how it relates to chronic kidney disease. The purpose of this project is to develop new cell culture methodology using innovative 3D bioprinting technology to isolate the pathological effects of low potassium on the kidney’s proximal tubule.

PI_NAMEs: BOYD-SHIWARSKI, CARY RAGAN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Acceleration;access restrictions;Agriculture;Alternative Complement Pathway;American;Apical;Biological Models;bioprinting;Cardiovascular Diseases;Cell Culture Techniques;Cell Line;Cell model;Cell Survival;Cells;Chronic;Chronic Kidney Failure;Collagen;Complement Activation;Consumption;cytokine;design;Development;Didelphidae;Diet;Dietary Potassium;Distal convoluted renal tubule structure;Electron Microscopy;Endocrine;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;extracellular;Extracellular Matrix;Fibrosis;fluid flow;Food;Foundations;fruits and vegetables;Funding;Genes;Glomerular Filtration Rate;Goals;Grant;Health;Human;Hypertension;Hypokalemia;Immune;immune activation;Immune response;Immunofluorescence Immunologic;Immunologic Stimulation;In Vitro;Inflammation;inflammatory marker;Injury to Kidney;innovation;Intake;Kidney;Kidney Diseases;Link;Measures;mechanical force;Mediating;Methodology;Microfluidics;Modeling;monolayer;Morphogenesis;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;Pathologic;Patients;Perfusion;Permeability;Physiology;Pilot Projects;Play;Population;Potassium;Potassium Deficiency;Predisposition;pressure;Primary Cell Cultures;Process;Proteins;Proximal Kidney Tubules;Publications;Renal tubule structure;Research;Research Methodology;response;Role;salt sensitive hypertension;scaffold;shear stress;Soil;Stress;Structure;Surface;System;Technology;Testing;three dimensional structure;three-dimensional modeling;transcriptome;transcriptome sequencing;Tubular formation;Western Blotting;western diet

PROJECT_TITLE: Establishing new model systems to study low potassium induced kidney injury

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Infant Mortality;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: PROJECT NARRATIVE Syphilis screening during prenatal care visits is a significant public health need given the increasing prevalence, impact on women's and infant's health, and links with adverse birth outcomes and other health conditions across the life course. Recent increases in congenital syphilis infections have warranted state-level policy changes in prenatal screening recommendations to reduce these outcomes; however, barriers and facilitators to implementing these policies into clinical practice remain unknown. This project aims to address this gap by assessing the multilevel determinants that influence implementation of syphilis screening policies and identify implementation strategies for obstetric providers to facilitate translation of these policies into clinical care.

PI_NAMEs: GRINER, STACEY B (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Administrator;adverse birth outcomes;American College of Obstetricians and Gynecologists;Awareness;Behavior;Birth;Cessation of life;Clinic;clinical care;clinical practice;Clinics and Hospitals;Code;Congenital Abnormality;Congenital Syphilis;Consensus;Consolidated Framework for Implementation Research;Contracts;Country;Data;Decision Making;Development;Discipline of obstetrics;Early Diagnosis;effectiveness/implementation study;evidence base;evidence based guidelines;Fetal Death;Goals;Guidelines;Health;Health Services;high risk;Hospital Administration;Hybrids;implementation determinants;implementation facilitators;implementation science;implementation strategy;in utero;Infant;Infant Health;Infection;infection burden;Interview;Knowledge;Legal;Life Cycle Stages;Link;Live Birth;Logic;Maps;maternal morbidity;Methods;Modeling;Mothers;neonatal morbidity;Neonatal Mortality;Nurse Midwives;Nurse Practitioners;obstetric care;Outcome;Patients;Performance;Persons;Physicians;Policies;Population;practice setting;Pregnancy;pregnant;prenatal;Prenatal care;prenatal testing;Prevalence;prevent;Prevention;Process;Professional Organizations;Provider;Public Health;Qualitative Methods;Recommendation;Registered nurse;Research;Research Design;Risk;Safety;screening;screening guidelines;screening policy;Spontaneous abortion;Statutes and Laws;stillbirth;Syphilis;System;Testing;Texas;theories;Translations;tv watching;Visit;Woman

PROJECT_TITLE: Multilevel determinants of prenatal syphilis screening policy implementation

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: ROOTSTOWN

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE The blood-brain barrier blocks nearly 98% of small molecules and nearly all macromolecules and proteins, preventing the entry of most therapeutics that are designed to target and treat neurological, psychiatric, or other central nervous system disorders. Here, we will further investigate our newly designed peptide conjugation strategy that can be used to deliver macromolecules and proteins efficiently across the BBB, as demonstrated in our preliminary data. This project will characterize the distribution and excretion of our modified proof-of- principle fluorescent protein following its administration to wild-type and target-protein knockout mice to further demonstrate the safety and efficiency of our method.

PI_NAMEs: SHIN, WOO SHIK  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Affect;alpha-bungarotoxin receptor;Amino Acids;Binding;Binding Proteins;Biological Assay;Biological Products;Blood;Blood - brain barrier anatomy;Blood specimen;Blood Tests;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain region;Cells;Central Nervous System;Central Nervous System Diseases;Characteristics;Chemicals;Cholinergic Receptors;Clinical Trials;Color;Data;design;Drug Delivery Systems;Drug Targeting;Drug Transport;Endothelial Cells;enhanced green fluorescent protein;Enzyme-Linked Immunosorbent Assay;Esterification;Excretory function;Future;German population;Goals;Heart;Hippocampus;Hour;Image;imaging system;improved;in silico;In Vitro;in vivo;in vivo evaluation;in vivo imaging system;Injections;Insulin Receptor;interest;Intravenous;Investigational Drugs;Investments;Iron;Knockout Mice;Left;Libraries;Ligands;lipophilicity;Lung;macromolecule;Measures;Mediating;Methods;Microscopy;Modification;Mus;Neurologic;Neurons;next generation;Nicotinic Receptors;Nutrient;Organ;Outcome;Pathway interactions;Patients;Penetration;Peptides;Perfusion;Pharmaceutical Preparations;Pharmacologic Substance;physical property;polypeptide;prevent;Process;Property;Proteins;rational design;receptor;receptor binding;Reporting;Research;Safety;Sampling;side effect;Signal Transduction;Slice;small molecule;Specificity;Stains;Sugar Acids;Surface;Tail;targeted agent;Testing;TFRC gene;Therapeutic;therapeutic target;Time;Toxic effect;Toxin;transcytosis;Treatment Efficacy;tumor;uptake;Urinalysis;Urine;Veins

PROJECT_TITLE: Rational design and testing of blood-brain-barrier shuttle peptide

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Prevention

ORG_CITY: Columbus

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Randomized trials are the gold standard for assessing interventions for preventing and treating cancer, but even a well-designed and well-executed trial can fail to replicate outside of the study if characteristics of the trial sample and the target population differ in ways related to the effectiveness of the intervention. This project will develop a novel method of assessing the generalizability of trial results to external populations when factors that are associated with treatment effects are unmeasured in the trial. This work will have broad applicability beyond cancer trials, as generalizability is a universal concern of randomized trials across application areas.

PI_NAMEs: ANDRIDGE, REBECCA ROBERTS (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Age;American College of Surgeons;Area;Binding;Breast Cancer survivor;Cancer Control;Cancer Patient;cancer prevention;Cancer Survivor;Characteristics;Clinical Trials;Cohort Studies;Computer software;Data;data sharing;Data Sources;Databases;design;Effectiveness;Effectiveness of Interventions;Electronic Health Record;Enrollment;Ethnic Origin;Failure;Goals;Health Sciences;Health system;indexing;Individual;Internet;Intervention;Malignant Neoplasms;Measures;Methodology;Methods;Modeling;Modification;neoplasm registry;non-compliance;novel;Outcome;Participant;Patients;Pattern;Population;prevent;Proxy;public health relevance;Race;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Research Personnel;Sampling;Sampling Studies;SEER Program;Selection Bias;simulation;Source;study characteristics;Surveys;Survivors;Target Populations;Testing;treatment effect;Treatment Effectiveness;Treatment outcome;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: A sensitivity analysis framework for generalizing randomized clinical trial results in the presence of unmeasured treatment effect modifiers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (O2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: GOLDEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO SCHOOL OF MINES

ORG_STATE: CO

PHR: Microbial keratitis (MK) therapy by eye drops has many deficiencies including high frequency dosing and low dose delivery to target tissues of about 1-5%. We propose to develop drug eluting contact lenses capable of delivering about 50% dose to target tissues, allowing replacement of tedious drop therapy involving multiple drops each day with the use of a single contact lens for 3-days therapy, followed by another lens for 3-days, if needed. The proposed research aims to manufacture and characterize novel nanobarrier lenses and measure in vivo drug release and efficacy in an animal model.

PI_NAMEs: CHAUHAN, ANUJ  (contact);KOMPELLA, UDAY B

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acute;alpha Tocopherol;Aminoglycosides;Animal Model;Antibiotic Resistance;Antibiotics;Aqueous Humor;Bandage;Binding Proteins;Biocompatible Materials;Biological Availability;Blindness;Case Study;Combined Modality Therapy;commercialization;Contact Lenses;Cornea;Cystinosis;Data;design;Developing Countries;Development;Devices;Disease;dosage;Dose;Drainage procedure;Drops;Drug Delivery Systems;drug efficacy;Drug Kinetics;Dryness;Eating;efficacy study;Epithelium;Ethanol;Eye;Eyedrops;FDA approved;Fluoroquinolones;Frequencies;Future;Generations;Glaucoma;Goals;healing;Hour;Hydrogels;Hydrophilic Contact Lenses;improved;In Vitro;in vivo;Individual;Infection;Inflammation;innovation;insight;Ions;Keratitis;large scale production;Legal patent;lens;manufacture;Marketing;mathematical model;Measures;methicillin resistant Staphylococcus aureus;microbial;Modeling;Modulus;Moxifloxacin;New Zealand;novel;novel strategies;Oryctolagus cuniculus;Oxygen;Partition Coefficient;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Preparations;Prognosis;Property;Pseudomonas aeruginosa;Publications;Regimen;Research;Research Personnel;Resistance development;Shapes;Silicones;Staphylococcus aureus;Staphylococcus aureus infection;Sterilization;Surveys;Testing;Therapeutic;Time;Tissues;Tobramycin;tool;translational barrier;Vancomycin;Variant;Visual impairment;Vitamin E;Water;Wettability;wound healing

PROJECT_TITLE: Nanobarrier contact lenses for mono and combination therapy for treating microbial keratitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Staphylococcus aureus produces nano-sized extracellular membrane vesicles (MVs) with cargo that includes cytoplasmic and membrane proteins, as well as secreted virulence factors. This project aims to investigate the generation of S. aureus MVs in vivo in models of staphylococcal infection to better understand their contributions to pathogenesis. Results from this project will further our understanding of S. aureus MVs and may lead to new strategies for the treatment and diagnosis of S. aureus infections.

PI_NAMEs: WANG, XIAOGANG  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Air;Animal Model;Animals;Antibiotic Resistance;Antibiotic Therapy;Bacteria;Bacterial Adhesins;Biochemistry;Biological;Biological Assay;Bronchoalveolar Lavage Fluid;Bypass;Cell Culture Techniques;cell type;Cells;Cellular Membrane;cytokine;Cytolysins;Cytoplasmic Protein;cytotoxicity;Data;Diagnosis;Disease;disease model;Encapsulated;Environmental Risk Factor;expectation;experience;experimental study;extracellular;Gene Expression;Generations;Genus staphylococcus;Glean;Goals;Harvest;Human;human disease;Immune Evasion;Immune response;Immunology;In Vitro;in vivo;in vivo Model;Infection;Inflammasome;Inflammatory;insight;Integration Host Factors;interdisciplinary approach;Knowledge;Lavage;Leukocytes;Life;Lipase;Lipoproteins;Liquid substance;Macrophage;Mammalian Cell;Measures;Membrane;membrane activity;Membrane Proteins;Methodology;Microbe;microbial;Microbiology;Modeling;Molecular;Molecular Biology;Monitor;Mus;nanosized;neutralizing antibody;novel therapeutic intervention;nuclease;Nucleic Acids;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathology;Peptide Hydrolases;Perception;Physiological;Play;pneumonia model;Process;Production;Property;Protein Secretion;Proteins;Publishing;response;Role;Sampling;skin lesion;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;success;Superantigens;Surface;Testing;Tissues;Toll-like receptors;Toxin;transcriptome sequencing;Vesicle;Virulence;Virulence Factors

PROJECT_TITLE: In vivo production of Staphylococcus aureus extracellular membrane vesicles

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia affecting the elderly population. Apolipoprotein E4 (ApoE4) is recognized as the strongest risk factor for LOAD. How ApoE4 exerts this effect on LOAD remains unclear. The purpose of this project is to evaluate the effects of ApoE genotype on a new state-of-the-art ‘gene-edited’ rat model for the LOAD to more accurately investigate the pathogenesis of this condition and to provide a vital new preclinical model to the research community.

PI_NAMEs: VAN NOSTRAND, WILLIAM E. (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta deposition;Address;Affect;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;Animal Model;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Behavioral;Blood Vessels;cell type;Cells;Communities;comorbidity;Dementia;Development;Disease;early onset;Elderly;Endothelial Cells;Experimental Animal Model;gene editing technology;Gene Proteins;Generations;Genes;Genetic Drift;Genome;Genotype;Goals;human disease;Impaired cognition;Investments;Late Onset Alzheimer Disease;Microglia;Modeling;mouse model;Mus;Mutation;Neurons;novel;overexpression;Pathogenesis;Pathologic;Pathology;Patients;Peptides;Pericytes;Physiological;Population;potential biomarker;Pre-Clinical Model;Predisposition;presenilin;programs;Protein Isoforms;Rattus;Research;Research Design;Resources;Risk Factors;Rodent Model;Site;Smooth Muscle Myocytes;Source;Testing;Therapeutic Intervention;transgene expression;Transgenic Animals;Transgenic Mice;Transgenic Model;Transgenic Organisms

PROJECT_TITLE: Impact of ApoE in Novel Rat Models of Late-Onset AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (02)]


ORG_CITY: STILLWATER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: The success of pathogen transmission by mosquitoes is partly determined by the insect immune system. This project is aimed at a partial elucidation of the extracellular network of serine proteases and their noncatalytic homologs in a major vector species, which yields pehnoloxidases and reactive compounds to kill the invading pathogens. Acquired knowledge may be applied for disrupting human disease transmission in mosquitoes.

PI_NAMEs: JIANG, HAOBO  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acceleration;Anopheles gambiae;Anopheles Genus;anti-microbial peptide;antimicrobial;Baculoviruses;Biochemical;Cells;Clip;cofactor;Collaborations;Complement;Complex;Culicidae;cytokine;Cytolysis;Data;defense response;Development;disease transmission;Drosophila genus;Encapsulated;Enzymes;Epithelium;extracellular;Future;Genes;Genetic study;Homologous Gene;human disease;Immune;Immune signaling;Immune system;In Vitro;in vivo;Individual;Infection;Infectious Agent;Insect Proteins;Insecta;insight;Invaded;invention;Knowledge;Knowledge acquisition;Link;Malaria;Manduca;Manduca sexta;Measures;Mediating;Melanins;Midgut;Modeling;Monophenol Monooxygenase;mutant;Nature;novel strategies;Organism;overexpression;paralogous gene;Parasites;Parasitic infection;pathogen;Pathway interactions;Peptide Hydrolases;Plasmodium;Process;Proteins;Reaction;reconstitution;Research;resistance mechanism;response;reverse genetics;RNA Interference;RNA interference screen;Role;Serine Protease;Serpins;Site;Specificity;Substrate Specificity;success;System;Systems Integration;Techniques;Testing;thioester;Tissues;transmission process;Validation;vector

PROJECT_TITLE: The immune serine protease pathways in Anopheles gambiae

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]