FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative (Overall) The societal impact of Alzheimer’s Disease and related dementias is broad. In addition to studies that will lead to prevention and cure, we need to develop new knowledge about how health systems, policy makers and communities can address the needs of people at risk for or with these devastating diseases. The proposed Center to Accelerate Population Research in Alzheimer’s will leverage expertise across disciplines to expand and stimulate multidisciplinary studies that will improve outcomes for the growing population with or at risk for AD/ADRD.

PI_NAMEs: BYNUM, JULIE PW (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Archives;Area;Behavioral Risk Factor Surveillance System;cardiovascular risk factor;Caring;Collaborations;Communities;Complex;Consult;Consumption;cost;Country;Data;Data Sources;Dementia;design;Diffusion;Discipline;Disease;Disparity;Drug Prescriptions;drug quality;Economics;effective therapy;end of life;falls;Funding;Future;Goals;Government;Health;health care delivery;health care service organization;Health Services;Health Services Accessibility;Health system;Healthcare;Home;improved outcome;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Investigation;Investments;Knowledge;Leadership;Link;Long-Term Care;Medicare;Methods;Michigan;multidisciplinary;National Health and Nutrition Examination Survey;new technology;novel diagnostics;novel therapeutics;organizational structure;Outcome;Personal Satisfaction;Persons;Pilot Projects;Policies;Policy Maker;Population;population based;Population Research;Populations at Risk;Positioning Attribute;prevent;Prevention;Program Development;Public Health;Public Policy;Quality of Care;Ramp;Research;Research Personnel;Research Training;Resource Allocation;Resource Development;Resources;Science;social;Societies;Surveys;System;Time;tool;Training;Universities

PROJECT_TITLE: Center to Accelerate Population Research in Alzheimer's (CAPRA)


ADMINISTERING_IC: AG

ARRA_FUNDED: N

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;Area;Collaborations;Communication;Communities;Complex;Consult;cost;Data;design;Development;Discipline;Discipline of Nursing;dissemination strategy;Economics;Ensure;federal policy;Foundations;Funding;Goals;Government;Grant;Health;Health Care Research;Healthcare;Healthcare Systems;Infrastructure;Institution;International;Knowledge;Leadership;Measures;Medicine;Methods;Michigan;Monitor;novel;Observational Study;Persons;Pilot Projects;Policy Maker;Policy Making;Population;Population Research;Population Sciences;Process;Public Health Schools;Research;Research Design;Research Personnel;Research Support;Resources;Secondary to;social;Strategic vision;Structure;success;Technology;Time;tool;Training;Training Support;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE Research into Ebola virus infection has yielded therapeutic antibodies and an approved vaccine. But an expanded treatment repertoire, which exploits new targets is needed to combat the increasing frequency and severity of Ebola outbreaks. Completion of the multidisciplinary research proposed here will provide mechanistic insights into filovirus entry and the viral and host targets that could be exploited with novel therapies and immunogens.

PI_NAMEs: MUNRO, JAMES B (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TITLE: Dynamics and mechanisms of filovirus envelop glycoproteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: NORTON, EDWARD C. (contact)

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Area;care providers;Clinical;Collaborations;Communities;Complex;Country;Data;Data Set;Dementia;dementia burden;design;Discipline;Economics;Educational workshop;Ensure;experience;Financial Hardship;Financial Support;Funding;Goals;Government;Grant;Health;health care delivery;Health Care Research;health care service organization;Healthcare;Healthcare Systems;Influentials;innovation;Institution;Interdisciplinary Study;Leadership;Measurement;medical schools;Mentors;Mentorship;Methods;Michigan;Minority;novel;Organizational Policy;Outcome;Pilot Projects;Play;Policies;Population;population based;population health;Population Research;Process;Program Development;Provider;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scholars Program;Science;Secure;social;success;Talents;Testing;timeline;tool;Translating;Universities;Work;Writing

PROJECT_TITLE: Pilot Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROOTSTOWN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE GABA is the principal inhibitory neurotransmitter that plays a critical role in survival functions such as selecting and locating salient sounds from the environment. During aging GABA is downregulated over time thus, it is vital to understand how GABAergic functions change throughout life to develop therapeutic approaches for those people with age-related hearing loss or other auditory dysfunctions. The present proposal will answer critical questions about the neural circuitry that underlies changes to GABAergic functions during aging.

PI_NAMEs: MELLOTT, JEFFREY GARRETT (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Affect;Age;age acceleration;age related;age related changes;Aging;aging auditory system;aging process;Antibodies;Appearance;Auditory;Auditory area;Auditory Brainstem Responses;auditory nuclei;Auditory Perceptual Disorders;auditory processing;Auditory system;Auditory Threshold;Behavior;Cells;Cochlea;Compensation;Data;Degenerative Disorder;design;Detection;Disease;Down-Regulation;Electron Microscopy;emerging adult;Environment;experimental study;Frequencies;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Gold;hearing impairment;Hearing problem;Immunochemistry;Immunoelectron Microscopy;Impairment;Inferior Colliculus;Knowledge;Label;Life;light microscopy;Measures;Midbrain structure;neural circuit;Neurons;Neurotransmitters;Noise;Pathway interactions;Perception;Peripheral;Persons;Phenotype;Physiology;Play;prepulse inhibition;Presbycusis;Publishing;receptor;Reflex action;Reporting;Research;Resolution;response;Risk Factors;Role;Signal Transduction;sound;Speech;Synapses;System;Techniques;Testing;Therapeutic;therapeutically effective;Time;timeline;Viral

PROJECT_TITLE: Age-related GABAergic loss in the central auditory circuits

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Area;benefit sharing;cardiovascular risk factor;Caring;cognitive function;Collaborations;Collection;Communities;cost effective;Country;Critiques;Data;Data Sources;Dementia;Demography;design;Development;Diagnostic;Diffusion;Discipline;Disparity;Economics;end of life;Faculty;Family Study;Fertilization;follow-up;Foundations;Funding;Future;Generations;Government;Health and Retirement Study;Health Care Research;health care service organization;Health Services Research;Individual;Infrastructure;Institution;Interdisciplinary Study;International;Knowledge;Learning;Medicaid;Medicare;meetings;member;Methods;Michigan;multidisciplinary;novel;Persons;Pharmaceutical Preparations;Pilot Projects;Policies;Population;population based;Population Research;recruit;Research;Research Activity;Research Personnel;Resources;Science;Scientist;sound;Speed;Surveys;synergism;System;Universities;Videoconferencing;Work

PROJECT_TITLE: External Network Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The proposed research is highly relevant to public health because it addresses the critical challenge of successful treatment for metastatic breast cancer and reducing endocrine therapy resistance in this disease. This study will elucidate potential new components of the ERα signaling pathway and advance the mechanistic understanding of breast cancer development and progression as well as emerging resistance to available endocrine therapies. This study could pave the way for new medical interventions to treat ERα+ breast cancer and benefit patients with advanced and metastatic cancers that are refractory to current endocrine therapies.

PI_NAMEs: WU, RAY-CHANG  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Ablation;Address;Advanced Malignant Neoplasm;ARID Domain;Aromatase Inhibitors;Binding;Biological Process;Biology;Breast Cancer Cell;Breast Cancer Treatment;cancer cell;cancer initiation;cancer recurrence;cancer risk;cancer stem cell;ChIP-seq;chromatin remodeling;clinically relevant;cohort;Complex;Coupled;Development;Disease;Disseminated Malignant Neoplasm;DNA;Enhancers;ESR1 gene;Estrogen Antagonists;Estrogen Therapy;Estrogens;Genes;genetic corepressor;Genetic Transcription;genome-wide;genomic data;Growth;helicase;hormone therapy;Human;Hybrids;in vivo;inhibitor;insight;Intervention;Investigation;knock-down;Knock-in Mouse;Knock-out;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mediating;Medical;Metastatic breast cancer;Molecular;mortality;mouse model;mutant;Mutation;Neoplasm Metastasis;novel;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Productivity;promoter;Proteins;Public Health;recruit;Refractory;refractory cancer;Relapse;Research;Resistance;Resolution;retinoblastoma binding protein 1;RNA;Role;Series;Signal Pathway;Signal Transduction;standard care;stemness;Testing;The Cancer Genome Atlas;therapeutic target;therapy development;therapy resistant;Time;Transcription Coactivator;Transcription Regulatory Protein;transcriptome;tumor;tumor initiation;tumor progression;tumor xenograft;tumorigenesis;Xenograft Model

PROJECT_TITLE: Molecular Function and Mechanism of ARID4B in ERalpha Signaling and Breast Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DAVIS, MATTHEW A (contact)

PROJECT_TERMS: Acceleration;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;care delivery;Censuses;Code;Cognitive;cognitive function;cohort;Communities;community-level factor;Complex;Data;data access;Data Aggregation;data archive;data centers;data reuse;Data Set;Data Sources;Databases;Dedications;Dementia;design;Economics;Ensure;Environment;Fostering;Geography;Health;Health and Retirement Study;Health Care Research;Health Surveys;Health system;Healthcare;Impaired cognition;innovation;interest;Interview;Learning;Measures;Medicare;Methodology;Michigan;Monitor;multidisciplinary;older adult;Outcome;Performance;podcast;population based;Population Research;Public Policy;Publications;Research;research and development;Research Personnel;Research Training;Resources;Series;Services;social;Surveys;Time;tool;Training;Training Activity;Training Support;Universities;virtual;web site;webinar;Work

PROJECT_TITLE: External Resources and Dissemination Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Prevention

ORG_CITY: WINNIPEG

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF MANITOBA

ORG_STATE: MB

ORG_ZIPCODE: R3T 2N2

PHR: PROJECT NARRATIVE This project will bring Big Data and artificial intelligence to infant nutrition research. We will study thousands of molecules in human breast milk to find out how they work together to support healthy growth and development during infancy and childhood. Our Milk Multi-omics (MuMi) Study will revolutionize the way human milk is studied and understood, and will help ensure better nutrition and health for future generations.

PI_NAMEs: AZAD, MEGHAN BRIANNE (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Affect;Anthropometry;Artificial Intelligence;atopy;Bacteria;Big Data;biobank;biological systems;Breast Feeding;Caring;Categories;Characteristics;Child;Child Development;Child Health;Childhood;Chronic Disease;cohort;Cohort Studies;Collaborations;complex biological systems;Data;Data Scientist;Data Set;design;Development;disorder prevention;early childhood;Ensure;Environmental Exposure;Environmental Risk Factor;Fatty Acids;feeding;Future Generations;Genetic;Grant;Growth;Growth and Development function;Health;Human;Human Milk;Hypersensitivity;improved;Individual;infancy;Infant;Infant Development;Infant Health;infant nutrition;Infection;Infrastructure;innovation;International;Lactation;Life;Life Style;lifestyle factors;machine learning method;Macronutrients Nutrition;Metadata;method development;microbiome;microbiota;Micronutrients;Milk;Milk Substitutes;Mothers;multiple omics;novel;Nutrient;nutrition;Nutritional Study;Oligosaccharides;Parents;Phenotype;Positioning Attribute;Pregnancy;programs;Proteins;Research;Research Personnel;Resolution;Resources;Sampling;Scientist;System;Systems Biology;Systems Development;unsupervised learning;Variant;Wheezing;Work

PROJECT_TITLE: The Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a biological system and understand its composition, determinants and impacts on child health


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Kidney Disease;Regenerative Medicine;Urologic Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE With priority emphasis on the recruitment and participation of under-represented minority groups, women and non-traditional students, this new summer institute undergraduate research program at the Wake Forest Institute for Regenerative Medicine (WFIRM), will provide 8 undergraduate students each summer (2022-2027) with 10- week summer research opportunities utilizing tissue engineering and regenerative medicine (TERM) strategies to address challenges relevant to the prevention, treatment and, ultimately, cure of kidney and urologic diseases. This broad research experience will be supplemented with extensive mentoring, hands-on instrumentation training, didactic educational experiences, specialized training with workshops on bioethics, responsible conduct of research, health disparities, effective oral and written communication, and program-tailored education and career development perceptions and intentions evaluation interventions. We also include special introductory short courses to familiarize students with the fundamentals of TERM with applications in KUD research and another towards understanding and addressing health disparities in DDKD.

PI_NAMEs: OPARA, EMMANUEL C. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Area;Assessment tool;Bioethics;Biological;Biological Sciences;Biomedical Engineering;Biomedical Research;Bladder;career;career development;cohort;Communication;Communities;Companions;Coupled;Development;didactic education;Disparity;Doctor of Philosophy;Education;Education Projects;Educational workshop;Engineering;Evaluation;experience;Faculty;First Generation College Students;Funding;Goals;Government;graduate student;health disparity;Health Sciences;Healthcare;Industry;Institution;instrumentation;Interdisciplinary Study;interest;Intervention;Kidney;Kidney Diseases;Knowledge;Learning;matriculation;Measures;Medicine;meetings;Mentors;Methods;Minority Groups;Minority-Serving Institution;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Non-traditional Students;novel;Oral;Participant;peer;Perception;physical science;Population Heterogeneity;posters;Prevention;programs;recruit;Regenerative Medicine;Research;Research Activity;Research Institute;Research Personnel;Research Priority;responsible research conduct;Schools;Science;Scientist;Self Perception;Site;skill acquisition;student mentoring;student participation;Students;success;summer institute;summer research;symposium;Tissue Engineering;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;Urologic Diseases;Urology;Virginia;virtual;Woman;Work;Writing

PROJECT_TITLE: Tissue Engineering and Regenerative Medicine Undergraduate Research Addressing Challenges in Kidney and Urologic Diseases

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE The proposed research is relevant to public health because the mitonuclear interaction is altered is altered in a number of different diseases including cancer, obesity, neurodegeneration, and aging. Given that the mechanisms regulating mitonuclear interaction are conserved from yeast to humans, understanding this genetic network may allow us to identify new therapeutic targets for potential interventions for human diseases associated with harmful consequences of mitochondrial dysfunction. Therefore, the research is relevant to NIGMS’s mission in supporting basic research that increases understanding of biological processes and laying the foundation for advances in disease treatment.

PI_NAMEs: KAYA, ALAATTIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Age;Aging;Basic Science;Biological;biological adaptation to stress;Biological Process;Cell Physiology;Cells;cellular engineering;Cellular Stress;Communication;Cytoprotection;Disease;fitness;Foundations;Functional disorder;Gene Expression;Genetic;Genome;Genotype;Goals;Haplotypes;Hemostatic function;heteroplasmy;Homeostasis;Human;human disease;Human Pathology;Huntington Disease;innovation;Intervention;Knowledge;Laboratories;Leber's Hereditary Optic Neuropathy;Link;Maintenance;Malignant Neoplasms;Metabolism;Mission;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;National Institute of General Medical Sciences;Nerve Degeneration;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;Pathway interactions;pharmacologic;Public Health;Research;Research Project Grants;Resistance;response;Role;Specificity;Stress;stressor;System;Testing;Yeasts

PROJECT_TITLE: The role of mito-nuclear communication in the adaptation to mitochondrial dysfunction and stress resistance

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative In the context of HIV infection, cannabis use is an important topic and is the most commonly used drug among HIV-infected individuals. Negative and positive effects of cannabis use in the context of HIV have been reported on various biological processes but the exact role and limits of chronic cannabis use on HIV cognition under immune perturbations remain unclear. This proposal focuses on clinical and preclinical approaches to explore the effects and mechanisms of cannabis-associated oral microbiome on neurocognitive performance in HIV disease.

PI_NAMEs: FITTING, SYLVIA  (contact);JIANG, WEI

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acceleration;Actinomyces;Actinomyces odontolyticus;Age;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;Anti-Bacterial Agents;Anti-Retroviral Agents;antiretroviral therapy;Bacteria;Bacterial Antigens;bacteriome;Behavioral;Biological Process;Blood;Brain;Cannabis;Cardiovascular Diseases;cell free DNA;cell motility;Central Nervous System;Chronic;Clinical;Cocaine Users;Cognition;Cognitive deficits;cognitive enhancement;cognitive function;cognitive performance;comparison control;cytokine;Data;Dental Hygiene;Deposition;Disease;Dose;Drug usage;Endocannabinoids;Feces;Frequencies;Genetic Transcription;Goals;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Immune;immune function;Impaired cognition;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Link;Long-Term Effects;Macrophage;marijuana smoker;marijuana use;marijuana user;Mediating;Memory;Memory impairment;Memory Loss;memory recognition;microbiome;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mycobiome;Myeloid Cells;neuroAIDS;Neurocognition;Neurocognitive;Neuropathogenesis;neuropathology;neurotoxicity;novel;Oral;oral bacteria;Oral cavity;oral microbiome;Pathogenesis;Pathway interactions;Patients;Peptides;Peptidoglycan;Performance;Persons;Pharmaceutical Preparations;Plasma;Play;pre-clinical;Premature Birth;Probiotics;Production;Prospective cohort;Proteins;Regulation;Reporting;Role;Saliva;Signal Pathway;Smoker;THC exposure;Therapeutic;Time;TLR2 gene;tobacco smokers;transcription factor;Transgenic Mice;Transgenic Organisms;Virus Diseases;Work

PROJECT_TITLE: Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis users

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Depression;Headaches;Mental Health;Migraine;Neurosciences;Pain Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: Psychedelics have shown promise for the treatment of depression and other mental health disorders. However, many questions remain on what mechanisms and pharmacological profiles psychedelics must possess for anti-depressant potential. This proposal seeks to develop chemical probes for key serotonin receptors known to be activated by psychedelics for the purpose of determining which signaling pathways and receptors are necessary for psychedelic versus therapeutic potential. 1

PI_NAMEs: MCCORVY, JOHN D (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Address;Agonist;analog;anti-depressive agents;antidepressant effect;Arrestins;beta-arrestin;Chemicals;Clinical Research;Communities;Data;design;Development;diphenyl;Disease;Dissociation;Drug Design;drug discovery;Engineering;Exhibits;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Hallucinogens;Head;HTR2A gene;Human;in vivo;Investigation;Lead;Ligands;Measures;Mental Depression;Mental disorders;Mental Health;Migraine;Modeling;Modification;Molecular Conformation;Nervous System;novel;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenethylamines;piperidine;Positioning Attribute;preference;prevent;Process;psilocin;Psilocybin;Publishing;rational design;receptor;Recruitment Activity;Research;Rodent;scaffold;screening;Series;Serotonin;Serotonin Agents;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Pathway;Signal Transduction;Structure;Structure-Activity Relationship;Technology;Therapeutic;Therapeutic Effect;treatment strategy;triptans

PROJECT_TITLE: Structure-based Design of Selective Serotonin Biased Agonists as Chemical Probes for Psychedelic Potential

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Alzheimer’s disease is a degenerative brain disorder characterized by defects in memory, but is also associated with metabolic dysfunction, leading some to suggest that Alzheimer’s disease may also be a metabolic disorder. Fibroblast growth factor 21 (FGF21) is an endocrine factor that signals to the brain to maintain metabolic homeostasis, and pharmacological administration of FGF21 improves metabolic profiles in both rodents and humans with metabolic dysfunction. In this proposal, we will explore the therapeutic potential of FGF21 to attenuate the metabolic and pathological deficits associated with Alzheimer’s disease.

PI_NAMEs: POTTHOFF, MATTHEW JOSEPH (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapy;Animal Model;Attenuated;Back;blood glucose regulation;Body Weight decreased;Brain;Brain Diseases;Brain region;Cells;Central Nervous System;cholinergic neuron;Clinical Trials;Cognition;Cognitive aging;cognitive function;comorbidity;Cytoprotection;Data;Defect;Dementia;Diabetes Mellitus;Disease;Disease Progression;Dissection;effective therapy;Endocrine;Fatty acid glycerol esters;FGFR1 gene;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Genes;Genetic;glucose metabolism;GLUT 4 protein;Glycoproteins;Hippocampus;Homeostasis;Hormones;Human;hyperphosphorylated tau;Impaired cognition;Impairment;improved;In Vitro;in vivo;Induced Neurons;innovation;Insulin;insulin sensitivity;insulin signaling;Knock-out;Knowledge;Learning;Life Expectancy;Liver;Long-Term Potentiation;Mediating;Memory;Memory impairment;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;mimetics;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuronal metabolism;Neuronal Plasticity;Neurons;neuroprotection;neurotransmission;nonhuman primate;novel;novel strategies;Obesity;Oxidative Stress;Pathologic;Pathway interactions;Peripheral;pharmacologic;Physiological;Physiological Processes;Physiology;Play;prevent;Publishing;receptor;reduce symptoms;response;Rodent;Role;Signal Transduction;Slice;spatial memory;Specificity;Stress;symptomatic improvement;Symptoms;Techniques;Thalamic structure;Therapeutic;Tissues;Up-Regulation;Vertebral column;way finding;Wild Type Mouse;Work

PROJECT_TITLE: Therapeutic Potential of FGF21 for Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: NARRATIVE (Overall) Epigenetic Therapy aims to treat cancer by blocking enzymes that control regulation of abnormal cellular identity in cancer. In doing so, these therapies also make immunotherapies more effective. This SPORE proposal seeks to improve on current epigenetic therapies by exploring new targets, new ways of combining epigenetic therapy with other cancer therapies, and by designing and running clinical trials of these new strategies.

PI_NAMEs: BAYLIN, STEPHEN B.;ISSA, JEAN-PIERRE J. (contact);JONES, PETER A

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Address;analysis pipeline;Biochemical;Biological Markers;cancer cell;Cancer Patient;cancer therapy;cancer type;career;Cells;chemotherapy;chromatin remodeling;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;Cultured Cells;Cyclin-Dependent Kinases;design;Development;DNA Damage;DNA Methylation;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;Dreams;drug action;Drug Combinations;drug testing;Ensure;Enzymes;epigenetic drug;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenetic therapy;EZH2 gene;Funding;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Genomics;Goals;Hematologic Neoplasms;Histone Deacetylase;Immune;Immune checkpoint inhibitor;immune modulating agents;Immunocompetent;Immunologic Monitoring;Immunotherapy;improved;Inflammasome;inhibitor;inhibitor therapy;Interferons;Isocitrate Dehydrogenase;Link;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mentors;Modification;Molecular;Mus;Nature;next generation;novel;novel therapeutic intervention;Pathology;Patients;Pattern;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase I Clinical Trials;Phase I/II Trial;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;programs;Regulation;repaired;Repetitive Sequence;Repression;Research;Research Personnel;Research Project Grants;Resistance;response;response biomarker;Running;Science;Signal Transduction;Solid Neoplasm;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapy Clinical Trials;therapy resistant;Tissues;translational pipeline;Translational Research;translational study;tumor;tumor growth;Work

PROJECT_TITLE: Epigenetic Therapies - New Approaches


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: PROJECT NARRATIVE The Administrative Core will provide the support and infrastructure for research and financial oversight; clear and open communications among all SPORE investigators, patient advocates, and developmental awardees; and regulatory monitoring to optimize the successful outcome of the translational research in epigenetic therapy for cancer.

PI_NAMEs: ISSA, JEAN-PIERRE J. (contact)

PROJECT_TERMS: Address;Administrator;Advocate;Award;cancer care;Cancer Prognosis;cancer therapy;career;Clinic;Clinical;clinical research site;Clinical Trials;Collaborations;Communication;Complex;Consultations;Data;data sharing;Decision Making;design;Development;Electronic Mail;Eligibility Determination;Ensure;epigenetic therapy;experience;Genomics;Grant;improved;Infrastructure;Institution;interdisciplinary collaboration;Interdisciplinary Study;Laboratories;Leadership;lectures;Malignant Neoplasms;Medical Research;meetings;Minority;Monitor;National Cancer Institute;novel;novel therapeutic intervention;Outcome;Pathology;Patients;Policies;Preparation;programs;Progress Reports;Protocols documentation;Publications;quality assurance;Quality Control;recruit;Regulation;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;screening;Strategic Planning;success;Supervision;symposium;Therapeutic Studies;Translational Research;United States National Institutes of Health;web site;Woman;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The Stanford CIMAC center will provide access to a suite of state-of-the-art immune assays, many of them developed or refined at Stanford and work collaboratively with the other CIMAC centers as well as the CIDC, clinical trial teams, NCI, PACT/FNIH and pharma collaborators. Our unmatched set of technologies will facilitate the discovery of new biomarkers for predicting cancer outcome or therapeutic response, as well as defining potential new mechanisms of immune control of cancer.

PI_NAMEs: BENDALL, SEAN CURTIS;MAECKER, HOLDEN T. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: ATAC-seq;Biological Assay;Biological Markers;Biometry;Cancer Center;cancer clinical trial;Cancer Control;Cells;Clinical;Clinical Data;Clinical Trials;Collaborations;Correlative Study;Data;Data Commons;data submission;Databases;Elasticity;Ensure;Grant;Guidelines;Image;Immune;Immunologic Monitoring;Immunology procedure;Immunotherapy;innovation;Lead;Machine Learning;Malignant Neoplasms;Measures;meetings;Mining;Mission;nano-string;novel;Outcome;Phenotype;Polysaccharides;predictive marker;Proteomics;Publishing;Quality Control;Regimen;regression algorithm;Research;Sampling;single cell genomics;Specific qualifier value;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Standardization;T cell receptor repertoire sequencing;Techniques;Technology;Testing;transcriptome sequencing;transcriptomics;treatment response;Work;working group

PROJECT_TITLE: Stanford Cancer Immune Monitoring and Analysis Center (CIMAC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE The Genomics, Epigenomics, and Bioinformatics Core will provide personnel, equipment, and expertise to support all projects of Epigenetic Therapy SPORE. The Core will be a resource for design and execution of genomic and epigenomic experiments, data acquisition, quality control, bioinformatic analysis, data management, sharing and distribution. The Core will support translational research and clinical trials in epigenetic therapy of cancer.

PI_NAMEs: JELINEK, JAROSLAV  (contact)

PROJECT_TERMS: biobank;Bioinformatics;cancer cell;cancer therapy;CDK4 gene;CDK9 Protein Kinase;Cells;Cessation of life;ChIP-seq;Chromatin;Clinical;Clinical Research;Clinical Trials;Collection;Complex;Cyclin-Dependent Kinases;Data;data acquisition;Data Analyses;data management;data sharing;design;DNA Integration;DNA Methylation;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNA Sequence Alteration;Endogenous Retroviruses;Epigenetic Process;epigenetic therapy;epigenomics;Equipment;exhaustion;exome sequencing;experimental study;EZH2 gene;Gene Expression;Gene Mutation;Genetic Markers;Genetic Transcription;genome-wide;Genomics;Goals;high dimensionality;high throughput analysis;Human Resources;Immune;Immune checkpoint inhibitor;Immunologic Sensitization;Immunotherapy;Inflammasome;inhibitor;innovation;Intervention;machine learning algorithm;Methylation;Mutation Detection;novel therapeutic intervention;Pathology;Polycomb;Population;Pre-Clinical Model;preclinical study;predicting response;Principal Investigator;prospective;Quality Control;Repetitive Sequence;Research Project Grants;Resources;Sampling;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Sorting;Statistical Data Interpretation;synergism;T-Lymphocyte;targeted treatment;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;Translational Research;translational study;tumor;Tumor Tissue

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prevention;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Bladder cancer has been termed the most expensive cancer to manage because of the high relapse rates and need for repeated monitoring. Novel strategies to decrease relapse rates for patients with bladder cancer therefore have important implications for the public health in general.

PI_NAMEs: SVATEK, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: PARNES, HOWARD L

PROJECT_TERMS: Address;Adverse effects;Affect;Age;age related;Age-associated memory impairment;Antigens;antitumor effect;Attention;Autologous;BCG Live;Biopsy;Bladder;bladder cancer prevention;Bladder Neoplasm;Bladder Tissue;cancer immunotherapy;Cancer Patient;cancer prevention;cancer risk;Cells;Cessation of life;chemotherapeutic agent;Cognition;cognitive function;cost estimate;Cystectomy;cytokine;Data;detrusor muscle;Development;Diagnosis;Dose;Double-Blind Method;early phase clinical trial;Elderly;Encapsulated;Event;Excision;exhaust;exhaustion;Exhibits;Formulation;Genomic Instability;Growth Factor;high risk;Human;Human Resources;Immune;immune function;Immune response;Immune System Diseases;Immunity;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;insight;instrument;intravesical;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Medical;Memory;men;Monitor;mTOR inhibition;mTOR Inhibitor;neoplastic cell;Newly Diagnosed;non-muscle invasive bladder cancer;novel;novel strategies;Nutrient;older patient;Organ Transplantation;Organism;Outcome;Outcome Measure;Pathologic;Patient Outcomes Assessments;Patients;Penetration;performance tests;pharmacokinetics and pharmacodynamics;Phase;Phase II Clinical Trials;phenotypic biomarker;Physical Function;Physical Performance;Placebo Control;Placebos;Population;Pre-Clinical Model;prevent;Prevention;primary outcome;Procedures;Production;Proliferating;Property;Public Health;Publishing;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recurrence;Recurrent disease;Relapse;relapse patients;Reporting;response;Risk;Safety;Secondary Cancer Prevention;Secondary Prevention;Sirolimus;standard care;standard of care;Symptoms;T cell differentiation;T memory cell;T-Lymphocyte;Testing;Training;Transitional Epithelium;tumor;Tumor Immunity;Urethra;Work

PROJECT_TITLE: eRapa for bladder cancer prevention

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


PHR: NARRATIVE The Pathology/Biospecimen/Biorepository Core will provide support to the projects of the Epigenetic Therapy SPORE. The Core support will enable the collection and utilization of valuable patient clinical specimens for use in the Projects correlative science analyzes that will provide insight into the mechanisms of therapy. It will also provide a biobank to be used by the science community to investigate new research questions.

PI_NAMEs: WILLIAMS, BART O (contact)

PROJECT_TERMS: Aftercare;AML/MDS;Animal Model;bead chip;biobank;Biological Assay;Biological Markers;Biological Process;Biological Specimen database;Biopsy;Blood;Bone Marrow;Bone Tissue;brca gene;Cell Count;Cell Line;Cells;Clinical;Clinical Data;clinical trial protocol;Clinical Trials;cohort;Collaborations;Collection;Communities;Data;Databases;digital imaging;DNA;DNA Methylation;efficacy evaluation;Endogenous Retroviruses;Epigenetic Process;epigenetic therapy;Evaluation;exhaustion;EZH2 gene;Flow Cytometry;Gene Expression;Generations;Genomics;Goals;Histology;Image;image archival system;Immune;Immunohistochemistry;Immunologic Markers;Immunologic Monitoring;Immunophenotyping;Indiana;insight;Institution;Label;Laboratories;Location;Malignant Neoplasms;Maryland;Measures;Methylation;Monitor;novel therapeutic intervention;Nucleic Acids;Participant;Pathologic;Pathology;Patients;performance site;peripheral blood;Phenotype;Principal Investigator;Procedures;Process;prospective;Randomized;Refractory;Relapse;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Science;Serum;Services;Site;Specimen;T-Lymphocyte;Technology;Testing;therapeutic evaluation;Time;Tissue Microarray;Tissues;transcriptome;treatment response;tumor;Universities

PROJECT_TITLE: Pathology Core


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE  The Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program seeks to support participation of 25 first-year medical students in a rigorous, hands-on laboratory research experience for 8-10 weeks during the summer. The major objective of the Med Students SOAR program is to promote broader participation of physicians in all aspects of supporting and engaging with cancer research. Under the mentorship of our renowned faculty, students will not only develop technical and laboratory skills through individualized research projects but also learn about delivering research-driven multidisciplinary and personalized oncology care through lectures, workshops, clinical observations, and simulation trainings, which will further promote long-term pursuit of careers in basic, translational, and clinical cancer research.

PI_NAMEs: GUNTHER, JILLIAN REBECCA;MELANCON, MARITES PASUELO (contact);SHANNON, VICKIE

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Allied Health Profession;anti-cancer research;Area;Award;Basic Science;Behavioral Research;Biomedical Research;Cancer Biology;cancer care;Cancer Center;career;Career Choice;career development;career networking;Caring;Clinic;Clinical;clinical care;Clinical Oncology;Clinical Research;clinical training;Communication;Country;Development;disability;Discipline of Nursing;Doctor of Philosophy;economic disparity;Education;education research;Educational Curriculum;Educational workshop;Elevator;Eligibility Determination;Emergency Situation;Ensure;Environment;Ethnic Origin;Ethnic Population;Evaluation;experience;Exposure to;Faculty;faculty mentor;First Year Experience;Funding;Future;Gender;Goals;Grant;hands on research;Hospitals;Image;improved;innovation;insight;Instruction;interest;International;Internships;Interview;Knowledge;Laboratories;Laboratory Research;Lead;Learning;lectures;Malignant Neoplasms;Medical;medical specialties;Medical Students;Medicine;member;Mentors;Mentorship;Methods;Mission;multidisciplinary;NCI-Designated Cancer Center;next generation;Nurses;Oncology;Oral;Participant;Patient Care;peer;peer coaching;Peer Review;Pharmacists;Physician Assistants;Physician's Role;Physicians;Play;Positioning Attribute;Postdoctoral Fellow;posters;precision oncology;Process;programs;Publications;Publishing;Qualifying;Race;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Support;Residencies;responsible research conduct;Role;Rotation;Series;simulation;skills;social;Social Workers;Speech;Structure;Students;summer program;summer student;symposium;Talents;Training;Training and Education;Translational Research;Underrepresented Populations;University of Texas M D Anderson Cancer Center;Writing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Drug-resistant tuberculosis is a major health concern which requires updated and improved diagnostic tools to inform individualised and standardised treatment protocols. There is a particular need for tests that can provide rapid results in high-throughput laboratories. This project will provide such tools in the form of microvolume, arrayed tests based on growth detection by means of standard methods and fluorescent probes.

PI_NAMEs: KLOPPER, MARISA  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;biobank;Biological Assay;Biological Sciences;career;Career Mobility;Cells;Clinical;Clinical Management;clinical sequencing;cost;Data;Detection;detection platform;Development;Diagnostic;diagnostic accuracy;diagnostic development;Diagnostic tests;diagnostic tool;distinguished professor;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Evaluation;Exclusion;experience;Fluorescence;Fluorescent Probes;Funding;Future;genomic locus;Genomic Segment;Genotype;Genus Mycobacterium;Goals;Growth;Health;improved;improved outcome;Incubated;ineffective therapies;Institutional Review Boards;International;Knowledge;Laboratories;Lead;Libraries;Linezolid;low and middle-income countries;Medical Research;Mentors;Metabolism;Methods;Microbiology;Molecular;Molecular Epidemiology;Moxifloxacin;Mycobacterium tuberculosis;next generation;next generation sequencing;novel;novel therapeutics;Oral;Outcome;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Positioning Attribute;Predisposition;Preparation;Process;programs;prospective;public health emergency;Randomized, Controlled Trials;rapid detection;Regimen;Research;Research Project Grants;Research Training;Resistance;resistance mutation;Resistance profile;Resource-limited setting;Rifampicin resistance;sample collection;Sampling;scale up;skills;South Africa;South African;Specificity;Specimen;Sputum;Standardization;targeted sequencing;tenure track;Testing;theories;Time;tool;Training;Treatment Protocols;Trehalose;Tuberculosis;tuberculosis drugs;United States National Institutes of Health;Universities;Update;Variant;Visualization;whole genome

PROJECT_TITLE: Development of a Next-generation Rapid Phenotypic Assay for Drug-Resistant M. tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Women's Health Research

PHR: NARRATIVE Epigenetic Therapy aims to treat cancer by blocking enzymes that control regulation of abnormal cellular identity in cancer. In doing so, these therapies also make immunotherapies more effective. This SPORE project seeks to improve on current epigenetic therapies by exploring a new target – CDK9, and testing a new drug in pre- clinical (and eventual clinical) combination studies.

PROJECT_TERMS: Achievement;Address;Affect;AML/MDS;Antigen Presentation;antitumor effect;Applications Grants;ATAC-seq;cancer cell;Cancer Model;cancer therapy;CDC2 gene;CDK4 gene;CDK5 gene;Cell Cycle;Cells;Cellular Assay;checkpoint inhibition;ChIP-seq;Clinic;Clinical;Clinical Drug Development;Clinical Trials;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinase Inhibitor 2A;Cyclin-Dependent Kinases;Data;Dendritic Cells;design;Development;DNA methyltransferase inhibition;DNA Modification Methylases;Dominant-Negative Mutation;Dose;Double-Stranded RNA;Drug Screening;Drug Targeting;efficacy study;Engineering;Enzymes;epigenetic drug;Epigenetic Process;epigenetic profiling;epigenetic silencing;epigenetic therapy;epigenome;expectation;falls;Gene Activation;Gene Expression;Gene Silencing;Genetic Transcription;Heart;Heterochromatin;Immune checkpoint inhibitor;Immune response;Immune system;immunoregulation;Immunotherapy;improved;inhibitor;interest;Interferon Type II;Interferons;leukemia;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;mouse model;Myeloid Leukemia;neoplastic cell;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Phosphorylation;pre-clinical;preclinical study;programs;promoter;Proteins;Regulation;Reporter;Repression;Resistance;response;Signal Transduction;System;T cell infiltration;T cell response;targeted treatment;Testing;Therapeutic Effect;Toxicology;transcriptome sequencing;trial comparing;tumor;Tumor Immunity;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Cyclin Dependent Kinases as Epigenetic Therapy Targets


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative: The aggregation of the huntingtin protein plays an important role in Huntington’s Disease. This proposal examines trillions of peptides to find rare molecules that can bind these huntingtin protein aggregates, but not the rest of the cell’s components, thereby rescuing normal cellular function. These peptides are designed to have biomarker and therapeutic potential and the same approach used here can also be applied to other age-related neurodegenerative diseases, such Alzheimer’s and Parkinson’s Disease.

PI_NAMEs: CHEN, JEANNIE ;LANGEN, RALF  (contact);ROBERTS, RICHARD W

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affect;Affinity;age related neurodegeneration;aggregation pathway;alpha helix;Alzheimer's Disease;Animal Model;Animals;Antibodies;Binding;Binding Sites;Biochemical;Biological;Biological Markers;biophysical techniques;Brain;Cell Culture Techniques;Cell model;Cell Physiology;Cells;Cellular Structures;Cultured Cells;Deposition;design;detection limit;Directed Molecular Evolution;Disease;disease model;Disease Progression;efficacy evaluation;Electron Spin Resonance Spectroscopy;Engineering;Exons;experimental study;Fluorescence;Fluorescence Microscopy;Foundations;Generations;Goals;Huntington Disease;Huntington gene;In Vitro;inhibitor;insight;interest;Interphase Cell;Ligands;Liquid substance;Messenger RNA;Methods;Molecular;monomer;mouse model;N-terminal;Neurons;novel;Oranges;Parkinson Disease;Pathway interactions;Patients;Peptides;Play;polyglutamine;potential biomarker;Process;Proline-Rich Domain;protein aggregation;protein function;protein structure;Proteins;Role;Site;specific biomarkers;Specificity;stoichiometry;Testing;Therapeutic;Time;Tissues;Toxic effect;Work

PROJECT_TITLE: Genetically Encoded Probes of Huntingtin Misfolding

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Osteoporosis

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants, increase the risk of fracture in humans, but the mechanisms by which they do so are not clear. The goal of this proposal is to determine the tissue, cellular and molecular mechanisms by which serotonin and SSRIs affect the musculoskeletal system in humans. This work will help elucidate the role of serotonin as a regulator of human skeletal health and guide the development of musculoskeletal screening and treatment strategies in those taking SSRIs and other antidepressants.

PI_NAMEs: WALKER, MARCELLA DONOVAN (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acute;Adrenergic beta-Antagonists;Adult;Affect;Affinity;Aging;American;Animals;anti-depressive agents;antidepressant effect;Area;Basic Science;Biological Assay;Biopsy;Body Composition;Body measure procedure;bone;Bone Density;bone health;bone loss;bone mass;bone metabolism;Bone Resorption;bone turnover;Brain;Categories;Chronic;Clinical Research;cohort;Communities;comorbidity;Data;Deterioration;Drug usage;Elderly;falls;Fluoxetine;Fracture;fracture risk;Gene Expression;Goals;Health;Height;high risk;Hip region structure;Human;human data;human old age (65+);indexing;inhibitor;insight;interdisciplinary approach;Measurement;Mediating;Mental Depression;Meta-Analysis;Molecular;mouse model;multi-ethnic;multimodality;Mus;Muscle;muscle form;Muscle function;Musculoskeletal;Musculoskeletal Development;Musculoskeletal System;Norepinephrine;Not Hispanic or Latino;novel;Observational Study;osteoblast differentiation;osteoblast proliferation;Osteoblasts;Osteogenesis;osteoporosis with pathological fracture;Participant;Peripheral;Pharmaceutical Preparations;Physical activity;Physical Function;Physical Performance;population based;Porosity;post stroke;Postmenopause;prevent;primary outcome;Proliferating;Psychotherapy;Publishing;Radial;Resolution;Resources;reuptake;Risk;Roentgen Rays;Role;Safety;screening;Selective Serotonin Reuptake Inhibitor;Serotonin;serotonin transporter;Site;skeletal;Skeletal Development;Structure;Sympathetic Nervous System;Time;Tissues;Trabecular Bone Score;Traction;Translating;treatment strategy;Vertebral column;Washington;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Serotonin and Skeletal Health

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Recent technological leaps have allowed us to obtain the genome sequences of a huge range of organisms, but our ability to understand the functions of the proteins encoded in those genomes lags far behind. We will develop high-performance methods to predict protein structure and function from sequence, and apply these methods to identify the proteins used by uropathogenic E. coli (the bacteria causing urinary tract infections) to cause disease.

PI_NAMEs: FREDDOLINO, LYDIA PETRA (contact);HULTGREN, SCOTT J.;SATCHELL, KARLA J F

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Acute;Amino Acid Sequence;Attention;Back;Bacteria;bacterial genetics;Bacterial Genome;Bacterial Proteins;Behavior;Binding Sites;Biochemical;Biochemistry;Biological;Biological Markers;Biological Models;biological systems;Biology;clinically relevant;cofactor;Communities;computerized tools;Computing Methodologies;Crystallography;Data;Databases;deep learning;Development;Disease;Drug Design;Escherichia coli;Escherichia coli K12;Escherichia coli Proteins;Experimental Genetics;experimental study;Failure;Feedback;Follow-Up Studies;Future;Genes;Genetic;Genome;genome-wide;High-Throughput Nucleotide Sequencing;Homologous Gene;Hospitalization;host colonization;Human;human pathogen;Human Resources;improved;In Vitro;in vivo;innovation;insight;interest;Intervention;Knowledge;Laboratories;Libraries;Ligands;method development;Methods;Microbe;microbial genome;Modernization;mouse model;Mycoplasma;Network-based;neural network;next generation;novel;Ontology;Organism;overexpression;Pathogenesis;pathogenic bacteria;pathogenic microbe;Performance;Pharmacologic Substance;Physiological;Physiology;predictive modeling;protein folding;protein function;protein protein interaction;protein purification;protein structure;Protein Structure Databases;protein structure prediction;Proteins;Proteome;public database;Public Health;Research;Resolution;Role;Sequence Homology;Set protein;Structure;Technology;Testing;therapeutic target;tool;Translating;United States;Urinary tract infection;Uropathogenic E. coli;Virulence;Virulence Factors;virulence gene;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Structure-based functional annotation of microbial genomes

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Lung;Lung Cancer

PHR: PROJECT NARRATIVE This SPORE project is highly relevant to human health and clinical management of solid tumors, inclusive of colorectal and lung cancer, with epigenetic therapies. Proposed mechanism-based and clinical studies will test novel hypotheses related to maximizing the utility of DNA methyltransferase and EZH1/2 inhibitors as a combinatorial therapeutic approach in solid tumors, where strategies for improving responses to epigenetic and immunotherapy drugs are desperately needed.

PI_NAMEs: ROTHBART, SCOTT  (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Antibodies;Antigen Presentation Pathway;antitumor effect;Antitumor Response;Behavior;Biological Markers;cancer cell;Cancer cell line;cancer subtypes;Cell Separation;Cell surface;Cells;checkpoint therapy;Chemicals;Chromatin;Clinical;clinical application;Clinical Management;Clinical Research;clinical subtypes;Colon Adenocarcinoma;Colon Carcinoma;Colorectal Cancer;Combination immunotherapy;combinatorial;Combined Modality Therapy;Comparative Study;Cytidine Deaminase Inhibitor;Data;defense response;demethylation;Deoxycytidine;derepression;design;disease classification;Disease Resistance;DNA;DNA Methylation;DNA Methyltransferase Inhibitor;DNA Modification Methylases;drug action;Elements;Endogenous Retroviruses;Enrollment;epigenetic drug;Epigenetic Process;epigenetic therapy;epigenomics;Excision;EZH2 gene;FDA approved;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Goals;Growth;health management;Human;Immune;immune cell infiltrate;Immune Evasion;immune modulating agents;Immune Response Genes;Immune signaling;Immunologics;Immunotherapy;improved;Inflammasome;inhibitor;inhibitor therapy;Interferons;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Modification;Molecular;mouse model;Mus;Nature;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;nucleoside analog;Oncogenic;Oral;Pathway interactions;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;Population;Pre-Clinical Model;pressure;Probability;programmed cell death protein 1;programs;Publishing;Refractory;Resistance;response;Sampling;Science;Signal Transduction;Solid Neoplasm;stem;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Toxic effect;trial design;tumor;tumor microenvironment;Tumor Suppressor Genes;Viral;Work

PROJECT_TITLE: Epigenetic Synergy Between DNMT and EZH1/2 Inhibitors for Therapy in Solid Tumors


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Neutrophils are white blood cells that kill the pathogens in infected tissue. We believe that this antibacterial function of neutrophils is activated by mechanical forces these cells experience as they migrate through vascular endothelial junctional barrier into infected tissue. The research will help us understand how the tension sensed by transmigrating neutrophil “educates” neutrophils to fight with tissue pathogens and hopefully lead to better treatments for patients with bacterial infection.

PI_NAMEs: KOMAROVA, YULIA A (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Address;Adherens Junction;Anti-Bacterial Agents;antimicrobial;Bacteria;Bacterial Infections;Calcium;cell killing;Cells;Cues;Data;Diameter;Endothelium;Exhibits;experience;experimental study;Family member;fighting;fungus;gain of function;Generations;Genes;genetic analysis;genetic approach;Genetic Transcription;Goals;Health;Heterogeneity;HIF1A gene;Host Defense;Human;improved;In Vitro;in vivo;Infection;Inhalant dose form;innate immune mechanisms;Invaded;Ion Channel;Irritants;Knockout Mice;Lead;Leukocytes;Link;Lung;Lung infections;Lytic;mechanical force;Mediating;Membrane;migration;Modeling;Molecular;mutant;NADPH Oxidase;neutrophil;Organelles;Oxidation-Reduction;pathogen;Patients;Phagocytosis;Phagolysosome;Phagosomes;pharmacologic;Phenotype;Piezo 1 ion channel;Play;pneumonia model;Process;programs;Property;Proteolysis;Pseudomonas aeruginosa pneumonia;Reactive Oxygen Species;Regulation;Research;Resolution;Role;Seminal;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;System;Testing;Therapeutic;Time;Tissues;Toxin;Up-Regulation;Vascular Endothelium

PROJECT_TITLE: Programming of PMN host-defense function during transendothelial migration

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence

ORG_CITY: IBADAN

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: CENTER FOR BIOETHICS AND RESEARCH, NIGERIA

PHR: Bridging Gaps in the ELSI of Data Science Health Research in Nigeria (BridgELSI) Project Narrative  The Bridging Gaps in the ELSI of Data Science Research (BridgELSI) Project is a collaborative research ethics study and training project that is focused on bridging the gaps in current governance framework on ethical oversight of data science health research by engaging key stakeholders to evaluate and co-develop novel governance framework for the Ethical Legal and Social Implications (ELSI) of data science health research in Nigeria. The project will implement short and medium-term training on ethics of data science for data scientists, ethicists and ethics committees, and strengthen the ethical working environment for data science health research in Nigeria. The project brings together talented and highly productive researchers at the Center for Bioethics and Research (CBR), Nigeria, George Washington University, DC and University of Maryland School of Medicine (UMSOM).

PI_NAMEs: ADEBAMOWO, CLEMENT ADEBAYO;OGUNDIRAN, TEMIDAYO OLUSADE (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;African;Artificial Intelligence;Attitude;Bioethics;Bioethics Consultants;Cellular Phone;clinical care;Committee Members;computerized tools;Computers;Conflict of Interest;Country;Data;data framework;Data Science;Data Scientist;design;Developed Countries;Development;Disease;Environment;ethical, legal, and social implication;Ethicists;Ethics;Ethics Committees;Guidelines;Health;health science research;Health Sciences;Healthcare;Human;Human Activities;improved;Informed Consent;Infrastructure;innovation;Institution;instrument;Intervention;Interview;Knowledge;Lawyers;Legal;low and middle-income countries;Machine Learning;Maryland;medical schools;member;Mentors;Methods;Modeling;Modernization;Nigeria;Nigerian;non-traditional data;novel;novel strategies;Outcome;Participant;participant safety;Play;Policies;Policy Maker;Productivity;programs;prospective;Public Health;rapid growth;Research;Research Ethics;Research Ethics Committees;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;Review Committee;Role;scale up;Site;Speed;Surveys;Talents;Technology;technology development;tool;Training;training data;Training Programs;training project;United States National Institutes of Health;Universities;Washington;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Though many caregiver-mediated preventative interventions have the potential to prevent adolescent substance use and promote positive social and emotional outcomes, their effectiveness is limited by low rates of caregiver home practice of intervention skills. The objective of this proposal is to develop and pilot implementation support strategies as an adjunct to an evidence-based preventative intervention by utilizing the digital behavior change framework. Findings will have a significant public health impact by identifying ways to increase individuals' intervention engagement and adherence broadly.

PI_NAMEs: KIM, JOANNA JANDEE (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Abbreviations;acceptability and feasibility;active control;Address;Adherence;Adolescent;adolescent substance use;Adult;Attention;Attitude;Behavior;behavior change;Caregivers;Cellular Phone;Child;Child Rearing;Competence;cost effective intervention;Data;Data Science;design;Development;digital;digital health;digital platform;Discipline;Education;Effectiveness;Effectiveness of Interventions;effectiveness trial;Emotional;Environment;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Family;Feedback;Frequencies;Future;Goals;group intervention;Habits;Health Technology;Home;implementation determinants;improved;in vivo;Individual;insight;Intention;Internet;Intervention;intervention delivery;intervention effect;intervention participants;junior high school;Language;Length;Long-Term Effects;Low income;Maintenance;Mediating;Mediator;Mental disorders;Mental Health;Mental health promotion;Mentored Research Scientist Development Award;Meta-Analysis;Methodology;Methods;Mexican Americans;mHealth;Modality;Monitor;novel;Outcome;Participant;pilot trial;Planning Theory;Positioning Attribute;Positive Reinforcements;post intervention;preference;prevent;Prevention program;preventive intervention;Problem Solving;Public Health;Randomized;randomized controlled design;rehearsal;relapse prevention;Request for Applications;Research;Research Personnel;research to practice;Resources;scaffold;School-Age Population;Science;skills;smartphone application;social;Social outcome;Spanish;Spanish/English;substance use;substance use prevention;Technology;Testing;theories;Theory of Change;therapy development;Time;Training;Training Support;Translating;user centered design;Youth

PROJECT_TITLE: Digital implementation support strategies for caregiver home practice

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project Narrative The proposed research is relevant to public health because it will directly test a novel epigenetic therapy and PARPi combination in the clinic. Associated correlatives and basic laboratory studies will reveal critical molecular insights into the mechanisms underlying synergy and resistance in BRCA-proficient breast and ovary cancer. Ultimately these findings will develop new treatment strategies with associated biomarkers for cancers with critical clinical need. Therefore, the proposed research is relevant to the NCI’s mission of supporting cancer research to advance scientific knowledge and help all people live longer, healthier lives.

PI_NAMEs: NEPHEW, KENNETH P (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;anti-cancer research;Biological Markers;Biopsy;BRCA deficient;BRCA mutations;BRCA1 Mutation;cancer biomarkers;Cancer Etiology;Cancer Patient;cancer subtypes;carcinogenesis;Cell Death;Cells;checkpoint therapy;chemotherapy;Chromosomal Rearrangement;Clinic;Clinical;cohort;Combined Modality Therapy;Complex;cytotoxicity;Data;Defect;DNA Damage;DNA Repair;DNA Single Strand Break;Dose;Double Strand Break Repair;Double-Stranded RNA;ds-DNA;epigenetic therapy;Funding;gene repair;Generations;Genes;Genetic Transcription;Germ Lines;Goals;Grant;homologous recombination;Immune;Immune response;Immune signaling;Immunocompetent;Impairment;improved outcome;In complete remission;In Vitro;in vivo;Inflammasome;inhibitor;inhibitor therapy;insight;Interferons;Knowledge;Laboratory Study;Lead;Link;Maintenance Therapy;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mediating;Metastatic breast cancer;Mission;Modeling;Molecular;Mus;Mutate;mutational status;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;PARP inhibition;partial response;Pathogenesis;Pathway interactions;Patients;Persons;Phase;phase 2 study;Phase I Clinical Trials;Phase I/II Clinical Trial;phase II trial;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;Progression-Free Survivals;Public Health;Reactive Oxygen Species;Relapse;repaired;Reporting;Research;Resistance;response;Risk;Sampling;Scientific Advances and Accomplishments;Serous;Signal Transduction;Site;synergism;Testing;The Cancer Genome Atlas;Therapeutic;TNF gene;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Viral;Woman;women's diagnosis

PROJECT_TITLE: Linking Epigenetic-Therapy Induction of Inflammasome Signaling to Generation of a BRCAness Phenotype


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Symptoms of autism spectrum disorder (ASD) emerge in infancy, yet many families have trouble accessing diagnostic services, and the average age of diagnosis in the United States remains over four years. The current project tests a novel tele-assessment instrument that can be delivered into homes, with activities presented by parents and guided by remote clinicians over a secure telehealth platform; we will examine the instrument's psychometric properties and diagnostic accuracy, as well as family satisfaction, empowerment, and ability to access intervention services. This method has potential to improve access to care, eliminate the time lag between ASD symptom emergence and diagnosis, and reduce disparities for under-served populations.

PI_NAMEs: OZONOFF, SALLY ;WARREN, ZACHARY E (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: access restrictions;Address;Affect;Age;Agreement;Assessment tool;autism spectrum disorder;autism symptoms;autistic children;barrier to care;Blinded;Caregivers;Caring;Characteristics;Child;Childhood;Classification;Clinical;clinical encounter;Communities;COVID-19 pandemic;Decision Making;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Services;Diagnostic Specificity;Diagnostic tests;disorder risk;Disparity;Disparity in diagnosis;disparity reduction;Early Intervention;Eligibility Determination;empowerment;Ethnic Origin;Evaluation;evidence base;experience;Face;Family;Family Characteristics;Feedback;geographic barrier;Geography;handheld mobile device;health disparity;Health Insurance Portability and Accountability Act;Health Services Accessibility;Home;Improve Access;improved;infancy;innovation;instrument;Laboratories;Life;Link;Measures;Mediating;medically underserved;Methodology;Methods;novel;Outcome;Parents;Pathway interactions;Perception;Performance;Persons;Population;Predictive Value;Primary Care;primary care provider;Procedures;Process;Property;Provider;Psychometrics;Questionnaires;Race;Randomized;recruit;remote administration;Reporting;Research;Research Personnel;Resources;rural setting;rural underserved;Sampling;satisfaction;screening;Secure;Self Efficacy;service engagement;service intervention;Services;Site;Socioeconomic Status;socioeconomics;sound;Specialist;Standardization;Stress;Surveys;System;Technology;tele-evaluation;telehealth;Telemedicine;tertiary care;Testing;Text;Time;time interval;Toddler;tool;underserved area;underserved community;Underserved Population;United States;Wait Time;Waiting Lists;Work

PROJECT_TITLE: Addressing disparities in ASD diagnosis using a direct-to-home telemedicine tool: Evaluation of diagnostic accuracy, psychometric properties, and family engagement

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Health Services;Huntington's Disease;Muscular Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_DEPT: NEUROLOGY

PHR: Over the past four years, we have established a highly efficient team and strong infrastructure at our combined CUIMC-WCM site capable of responding to the challenges of completing 4 phase 2 trials and 3 active trials. Six assistant professors completed 1-year NNEXT fellowships. If awarded, we will recruit diverse participants in early phase trials including ultra-rare genetic disorders and expand the fellowship.

PI_NAMEs: CHIRIBOGA, CLAUDIA A;MARDER, KAREN S (contact);SARVA, HARINI

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Academic Medical Centers;Adult;Advocate;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Appointment;Award;Binding Sites;Biological Markers;biomarker validation;Childhood;clinical center;clinical research site;Clinical Trials;Collaborations;community engagement;community research;Community Trial;Conduct Clinical Trials;Continuity of Patient Care;Dedications;design;Disease;Dose;Duchenne muscular dystrophy;early phase trial;Education;Educational Materials;Eligibility Determination;Enrollment;equity, diversity, and inclusion;ethnic diversity;Event;experience;Faculty;Family;Fellowship;Fellowship Program;Foundations;Funding;gene therapy;Gene therapy trial;Generations;Genetic Diseases;Goals;Grant;Growth;Hospitals;Huntington Disease;improved;Inborn Errors of Metabolism;Informatics;informatics tool;Infrastructure;inhibitor;innovation;Institution;investigator-initiated trial;Joints;Lead;Leadership;life span;Medical center;medical schools;Medicine;Methodology;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;Neurosciences;neurosurgery;New York;New York City;pandemic disease;Participant;Phase;phase 3 study;phase II trial;Phenotype;Physical Medicine;polyglucosan;Population Heterogeneity;precision medicine;Presbyterian Church;Principal Investigator;professor;Protocols documentation;racial diversity;rare condition;Rare Diseases;rare genetic disorder;recruit;Regenerative Medicine;Research;Research Personnel;RNA Splicing;Safety;Scientific Advances and Accomplishments;Site;small molecule;Spinal Muscular Atrophy;success;tool;Training;Universities;validation studies

PROJECT_TITLE: Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24 Clinical Trial Not Allowed)


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: PROJECT NARRATIVE (Developmental Research Program) The Developmental Research Program aims to support and develop research projects involving cancer epigenetics therapies with translational potential that will ultimately improve the survival and the quality of life of cancer patients.

PI_NAMEs: ISSA, JEAN-PIERRE J. (contact)

PROJECT_TERMS: American Association of Cancer Research;Award;Cancer Patient;cancer therapy;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Communication;Development;Dreams;Eligibility Determination;Ensure;Epigenetic Process;epigenetic therapy;flexibility;Fostering;Funding;Goals;Grant;Hematologic Neoplasms;high reward;high risk;improved;innovation;Institution;Investments;Laboratory Research;Leadership;Letters;leukemia;Mainstreaming;Malignant Neoplasms;Mission;Modeling;Monitor;Nature;novel;novel therapeutic intervention;Peer Review;Pilot Projects;pre-clinical;Process;programs;Quality of life;Recording of previous events;Research;Research Peer Review;Research Personnel;Research Project Grants;research study;Scientist;Selection Criteria;Solid Neoplasm;Source;Structure;success;Therapeutic Studies;Translating;translational potential;Translational Research;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The EEGLAB signal processing environment is now used in many electrophysiological research and teaching laboratories worldwide. To accelerate progress in basic and clinical cognitive neuroscience, we will continue its development and maintenance, introducing new tools for source separation, localization, and connectivity, and for across-studies metaanalysis, and will extend its scope to include processing of intracranial EEG data and multimodal mobile brain/body imaging (MoBI) data.

PI_NAMEs: DELORME, ARNAUD ;MAKEIG, SCOTT  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Affect;Algorithms;Anatomy;annotation  system;Architecture;Bayesian Modeling;Behavior;Behavioral;Brain;Brain imaging;brain research;California;Clinic;Clinical;Cognitive;cognitive neuroscience;Collection;Complex;computational neuroscience;Computer software;cost;cranium;Data;Data Analyses;data modalities;data structure;data visualization;density;Descriptor;Development;Disease;Educational process of instructing;Electroencephalography;Electronic Mail;Electrophysiology (science);Environment;Evaluation;Event;experience;Functional Imaging;graphical user interface;Head;Health;Human;Human body;Image;imaging modality;independent component analysis;Individual;innovation;interest;Internet;Laboratories;Learning;Life;light weight;Link;Links List;Location;Maintenance;Maps;mathematical methods;Measures;Meta-Analysis;Metabolic;Metadata;Methods;Modality;Modeling;Modernization;Motion;multimodal data;multimodality;Nature;network models;Neurology;Neurosciences;news;open source;Paper;Participant;Plug-in;Process;Psyche structure;Publishing;Reporting;Research;Research Methodology;Research Personnel;research study;Resolution;Respondent;Running;Scalp structure;Scheme;Seizures;signal processing;Signal Transduction;Source;source localization;Specific qualifier value;Statistical Algorithm;Structure;Surface;Surveys;Taiwan;teaching laboratory;Testing;Time;tool;tool development;Training;United States National Institutes of Health;Universities;Visualization software;Work

PROJECT_TITLE: EEGLab: Software Analysis of Human Brain Dynamics


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PHR: PROJECT NARRATIVE (Career Enhancement Program) The Career Enhancement Program fosters the scientific development of investigators who intend to focus their careers on translational studies of cancer epigenetic therapies. This is achieved by recruiting innovative entry- level scientists to enhance the SPORE’s overall translational research capability, helping these individuals develop intellectual and technical skills required to be productive investigators, and teaching these individuals basic principles of translational research.

PROJECT_TERMS: Academic advising;Acceleration;anti-cancer research;Applied Research;Area;Award;Basic Science;biobank;Biochemistry;Bioethics;Bioinformatics;Biology;Biometry;career;career development;Cellular biology;Clinical;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Collaborations;Dedications;design;Development;Dreams;drug development;Education;Educational process of instructing;Epidemiologist;Epidemiology;Epigenetic Process;epigenetic therapy;Evaluation;experience;Faculty;Fellowship Program;Fostering;Foundations;Funding;Future;Generations;Genetic;Genomics;Goals;Individual;innovation;Institution;interest;International;Investigation;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Manuscripts;member;Mentors;Mentorship;Methods;Minority;Molecular;Molecular Biology;novel;novel therapeutic intervention;Participant;Pathologist;pharmacokinetics and pharmacodynamics;Physicians;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Proteomics;Qualifying;Records;recruit;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;skills;Structure;success;Systems Biology;Talents;Technical Expertise;Time;Training;translational potential;Translational Research;translational scientist;translational study;Woman;Writing

PROJECT_TITLE: Career Enhancement Program


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Polycystic Ovary Syndrome (PCOS);Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Polycystic ovary syndrome (PCOS) is a major health concern that affects up to 10% of all reproductive-aged women; however, the treatment of PCOS remains limited by an incomplete understanding of the pathophysiology of the disorder despite extensive physiologic and genetic studies. The goal of this study is to dissect the underlying causes of PCOS by implicating causal biological mechanisms underlying the pathophysiology of PCOS, as well as PCOS-associated features in women, men, and children. The results of this proposal will allow for the deconstruction of the causes of PCOS into distinct subgroups, which will pave the way for a precision-medicine approach to the diagnosis, risk stratification, and treatment of PCOS in women and its associated conditions in men and children.

PI_NAMEs: ZHU, JIA  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Adult;Adult women;Affect;aged;androgen biosynthesis;androgenic;Asthma;Award;biobank;Bioinformatics;Biological;candidate identification;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder risk;Child;Childhood;Clinical;clinical care;cohort;Collaborations;Complex;Computational Biology;Computing Methodologies;Cues;Data;Data Set;Diagnosis;Disease;Dissection;Endocrine;Endocrine System Diseases;Endocrinology;experience;Female infertility;Fertility;folliculogenesis;Functional disorder;Gene Expression;Gene set enrichment analysis;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;genomic locus;Goals;Gonadotropins;Growth;Health;Health Care Costs;Heterogeneity;Hyperandrogenism;Individual;innovation;insight;insulin secretion;International;Link;Lipids;Longitudinal Studies;member;men;Mentorship;Meta-Analysis;Metabolic;Metabolic dysfunction;metabolomics;Methods;Molecular;National Institute of Child Health and Human Development;novel;Outcome;Ovarian;ovarian dysfunction;Parents;Pathogenesis;Pathway interactions;Pediatric cohort;Phenotype;phenotypic data;Physicians;Physiological;Polycystic Ovary Syndrome;polygenic risk score;Positioning Attribute;precision medicine;prepuberty;Puberty;Regulation;reproductive;Reproductive Endocrinology;Risk;risk stratification;Role;Scientist;sex;Sex Bias;skills;Specificity;Subgroup;Testing;therapeutic target;Training;trait;Variant;Weight;Woman

PROJECT_TITLE: Genetic Dissection of the Pathophysiology of Polycystic Ovary Syndrome

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ORG_DEPT: OTOLARYNGOLOGY

PHR: NARRATIVE Vertigo or dizziness rank amongst the most common reasons that patients seek medical care, especially among elderly patients. In part, these vestibular deficits are due to functional defects in vestibular hair cells. We intend to leverage the advantages of both zebrafish and mice models of vestibular hair cell dysfunction along with comparative studies of human vestibular hair cells to gain a better understanding of the molecular components required for sensory function of vestibular hair cells.

PI_NAMEs: CHENG, ALAN GI-LUN;NICOLSON, TERESA A (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Adolescent;Adult;Animal Model;Architecture;Behavior;Behavioral;Behavioral Assay;Calcium;Caring;Cell Physiology;cell type;Cells;Cellular Morphology;Characteristics;Cochlea;Comparative Study;Complex;Coupled;Data;Defect;Development;differential expression;Dizziness;Dyes;Electrophysiology (science);Evoked Potentials;Evolution;experimental study;Eye Movements;Fishes;Foundations;Frequencies;Functional disorder;Future;Genes;Genetic Transcription;Gravity Perception;Hair;hair cell regeneration;Hair Cells;Head;Human;in vivo;insight;Ion Channel;Label;Labyrinth;Larva;Link;link protein;live cell imaging;Mammals;mechanotransduction;Mediating;Medical;member;Membrane;Methods;Molecular;Molecular Profiling;Morphology;Motion;mouse model;Mus;mutant;Mutant Strains Mice;Natural regeneration;nerve supply;older patient;Organ;Organ Donor;Outer Hair Cells;Patients;Pattern;PCDH15 gene;Peripheral;Physiological;Physiology;Protein Isoforms;Proteins;Reflex action;Regulation;response;RNA;Role;Sensory;Sensory Hair;single cell analysis;single-cell RNA sequencing;sound;spatiotemporal;Stimulus;Study models;System;Testing;Therapeutic;Tissue Donors;Transcript;Type II Hair Cell;Utricle structure;Validation;Vertigo;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;vestibular reflex;vestibular system;vibration;Work;Zebrafish

PROJECT_TITLE: Diversification of the mechanotransduction complex in vestibular hair cells

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Cancer;Complementary and Integrative Health;Immunotherapy;Nanotechnology;Skin Cancer

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Melanoma is an aggressive cancer with high mortality rate and multiple modes of resistance to current standard-of-care therapies. We have determined that ferroptosis, a recently discovered mechanism of programmed cell death, is a promising method of killing melanoma cells which are resistant to other therapies, and that the tumor-infiltrating myeloid cells should be concurrently protected from ferroptosis to overcome immune tolerance to melanoma. We propose to develop novel therapy based on the differential regulation of ferroptosis in cancer and immune cells of the melanoma tumor microenvironment.

PI_NAMEs: BUNIMOVICH, YURI  (contact);KAGAN, VALERIAN E;NEFEDOVA, YULIA

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acceleration;Affect;Alcohols;alternative treatment;analytical tool;anti-tumor immune response;Apoptosis;Blood specimen;cancer cell;cancer therapy;Carbon Nanotubes;Cell Death;Cell Differentiation process;cell type;Cells;Cessation of life;checkpoint therapy;Clinical;clinically relevant;Complementary therapies;Complex;cytotoxic;cytotoxicity;Data;Death Rate;Development;disabled;Engineering;Genetic;Genetic Models;Glutathione;Goals;graphene;Human;imaging modality;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Tolerance;immunogenic;immunomodulatory strategy;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;Ions;Iron;Lipid Peroxidation;Lipid Peroxides;lipidomics;Lipids;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;MEKs;Melanins;Melanogenesis;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Skin Cancer;Methods;Modeling;Modernization;monocyte;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nanodelivery;nanodot;nanomaterials;Neoplasm Transplantation;neoplastic cell;neutrophil;novel;novel strategies;novel therapeutics;Outcome;oxidation;Oxidation-Reduction;Pathway interactions;Patients;pharmacologic;phospholipid-hydroperoxide glutathione peroxidase;Population;Predisposition;prevent;Process;Publishing;quantum;Refractory;Regulation;repaired;Resistance;Sampling;Signal Transduction;standard of care;System;T-Lymphocyte;Testing;Therapeutic;Tissue Sample;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-infiltrating immune cells

PROJECT_TITLE: Re-engineering differential regulation of ferroptosis in melanoma microenvironment

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Child obesity and overweight are leading preventable causes of many adulthood chronic diseases, including many types of cancers, ranking second only to tobacco use. The scientific premise of this proposal is to select, refine, and test network interventions aimed at increasing the adoption of evidence-based strategies among childhood obesity prevention coalitions serving communities with socioeconomic disadvantage. This study will help researchers and public health practitioners explore improving coalition uptake of evidence-based strategies, help coalition leaders maximize their organizing and mobilizing practices in childhood obesity prevention, and add to the public health research base on optimal knowledge and research translation.

PI_NAMEs: MOORE, TRAVIS ROBERT (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Acceleration;Adopted;Adoption;Adult;Applications Grants;arm;base;Behavior;behavior change;cancer type;career;Child;Child Health;Child health equity;Chronic;Chronic Disease;Cluster randomized trial;Collaborations;Communities;community based research;community organizations;Data;design;Diffusion;disorder prevention;effective intervention;Enrollment;Ensure;Environment;evidence base;experience;Experimental Designs;experimental study;Family;feasibility testing;Feedback;Goals;Grant;Health Disparities Research;health disparity;health equity;Heart Diseases;Household;implementation science;improved;Income;Individual;insight;Institution;Intervention;intervention mapping;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Longitudinal Surveys;member;Mentorship;Methods;Modeling;models and simulation;multidisciplinary;novel;Obesity;obesity in children;obesity prevention;Outcome;Overweight;peer;Phase;pilot test;Population;Poverty;Prevalence;Prevention;Process;Protocols documentation;Public Health;public health research;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Research Personnel;Resources;Risk;Schools;Science;simulation;skill acquisition;skills;Social Network;socioeconomic disadvantage;Structure;Study Skills;System;Testing;therapy development;Time;Tobacco use;Training;Translational Research;Translations;United States National Institutes of Health;uptake;Visualization

PROJECT_TITLE: Feasibility of Network Interventions to Facilitate Community Coalition Adoption of Evidence-Based Strategies for Child Obesity Prevention

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_DEPT: NEUROSURGERY

PHR: Lung cancer (LC) causes significant mortality and morbidity in the U.S. How to guide screenings for LC survivors is a critical and timely public health concern, as CT screening becomes the standard of care with increased LC survivors in the US population. From a public health perspective, our study has high impact because the completion of this study will provide a valuable decision tool for evaluating an individual’s risk of developing second primary lung cancer (SPLC) and a set of efficient screening strategies for SPLC among LC survivors, which will ultimately result in a substantial reduction of the LC mortality and, in turn, a substantial cost-savings for the healthcare system.

PI_NAMEs: HAN, SUMMER S (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Address;Artificial Intelligence;Asian;Behavioral;Biometry;California;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer risk;cancer survival;Cancer Survivor;Cessation of life;Clinical;Clinical Informatics;Clinical Trials;Communities;computed tomography screening;Consensus;Cost Savings;Data;Data Sources;Databases;Diagnosis;Electronic Health Record;electronic health record system;Eligibility Determination;epidemiologic data;Epidemiology;ethnic diversity;Ethnic Origin;General Population;Goals;Guidelines;Health;Healthcare;Healthcare Systems;high risk;Immunologic Markers;improved;Incidence;Individual;interest;Link;Longterm Follow-up;Lung;lung cancer screening;Malignant neoplasm of lung;Measures;Methods;Modeling;Morbidity - disease rate;mortality;neoplasm registry;neutrophil;never smoker;never smoking;novel;Oncology;Outcome;Patients;Pattern;Population;population based;Population Heterogeneity;predictive modeling;Public Health;Race;Radiology Specialty;randomized trial;Recording of previous events;Records;Registries;Research;Research Personnel;Risk;Risk Factors;risk prediction;screening;screening guidelines;sex;shared database;Smoke;Smoker;Smoking;smoking cessation;Smoking Status;standard of care;Statistical Methods;Survivors;targeted treatment;Thoracic Surgical Procedures;Time;tool;translational impact;Translational Research;United States Preventative Services Task Force;Universities

PROJECT_TITLE: Integrating Multiple Electronic Health Records Systems to Improve Lung Cancer Outcomes

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Schizophrenia is a chronic, prevalent, and disabling mental disorder, and efforts to develop more effective treatments are hindered by a lack of understanding of disease biology. The investigators have developed cellular models of synaptic pruning in schizophrenia, and will use these validated models to understand the effect of recently-identified risk genes on synaptic pruning by studying human microglia as well as neurons. This research will yield a prioritized list of potential treatment targets, and more generally provide a deeper understanding of the way genes may contribute to schizophrenia risk.

PI_NAMEs: PERLIS, ROY H.;SHERIDAN, STEVEN D (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Address;Alleles;Applied Genetic Engineering;Autopsy;biobank;Biological;Biological Assay;Biological Models;Biology;Brain;Brain region;Cell model;Cells;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complement 4b;Complement component C4a;CRISPR screen;Data;Dendritic Spines;density;Deposition;Development;Disabling;Disease;disorder risk;effective therapy;Engineering;Functional disorder;Gene Expression;gene function;Genes;Genetic Engineering;genetic manipulation;Genetic Variation;genome wide association study;genome-wide;Genomics;Heritability;Hippocampus;Human;human genomics;human model;Immune;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Investigation;Knock-out;Link;Maps;Measurable;Mediating;Mental disorders;Methods;Microglia;MicroRNAs;Modeling;Mus;neuroimaging;Neurons;novel;novel therapeutics;patient derived induced pluripotent stem cells;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;PF4 Gene;Phagocytosis;Phenotype;Prefrontal Cortex;Process;Proteins;Protocols documentation;Publishing;Research;Research Personnel;retinogeniculate;Risk;risk variant;Rodent Model;Role;Schizophrenia;schizophrenia risk;Slice;Specificity;Structure;Synapses;synaptic pruning;synaptogenesis;Synaptosomes;System;targeted treatment;therapeutic development;therapy development;transcriptomics;uptake;Variant;Work

PROJECT_TITLE: Characterization of schizophrenia liability genes in models of human microglial synaptic pruning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]