ORG_CITY: ST. PAUL

ORG_NAME: MINNESOTA STATE DEPT OF HEALTH

PHR: Project Narrative: Minnesota PRAMS is relevant to public health because the results approximate the number of women in the state who had certain health behaviors or experiences related to pregnancy, as well as identifies subgroups at higher risk (U.S.-born African American and American Indian). State programs use these results to evaluate the success of existing activities, laws and policies serving pregnant women and infants and to develop programs to address emerging areas of need. Finally, researchers use PRAMS results to explore the relationships between specific behaviors and experiences and how the health of women and infants is affected.

PI_NAMEs: SHEFF, MIRA GRICE (contact)

PROJECT_TITLE: RFA-DP-21-001 Minnesota Pregnancy Risk Assessment Monitoring System, Component A


ADMINISTERING_IC: DP

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UTAH STATE DEPARTMENT OF HEALTH

ORG_STATE: UT

PHR: Utah surveys 5% of mothers of live births to collect state-specific, population-based data on maternal behaviors and experiences before, during, and shortly after pregnancy for the Pregnancy Risk Assessment Monitoring System (PRAMS), a surveillance project of the Centers for Disease Control and Prevention (CDC) and state health departments. Utah PRAMS provides a rich source of data that is used by both researchers and policy makers to improve the health of mothers and infants.

PI_NAMEs: ANDJELIC, NICKEE  (contact)

PROJECT_TITLE: DP21-001 Utah Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: MENANDS

ORG_NAME: HEALTH RESEARCH INC, NEW YORK STATE DOH

ORG_STATE: NY

PHR: Project Narrative  PRAMS data provides important baseline information and ongoing measures, that are not available from other sources of New York’s progress in addressing five of the nine priorities in maternal and child health such as access and barriers to prenatal care, oral health during pregnancy, low birthweight and infant mortality, substance abuse during pregnancy, unintended pregnancy and breastfeeding.

PI_NAMEs: NGUYEN, TRANG Q (contact)

PROJECT_TITLE: DP21-001 Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPT/ HEALTH & SENIOR SRV

ORG_STATE: MO

PHR: PROJECT NARRATIVE The Pregnancy Risk Assessment Monitoring System (PRAMS) is a survey sent to a sample of Missouri women with a recent live birth, asking for information about their experiences, behaviors and attitudes before, during and shortly after their most recent pregnancy. Missouri PRAMS data helps identify groups of women and infants at high risk for health problems and adverse pregnancy/birth outcomes. The goal of the Missouri PRAMS project is to improve the health of mothers and infants by reducing adverse pregnancy outcomes.

PI_NAMEs: GARIKAPATY, VENKATA PHANI SEKHAR (contact)

PROJECT_TITLE: RFA-DP-21-001 MISSOURI PREGNANCY RISK ASSESSMENT MONITORING SYSTEM


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS STATE DEPARTMENT OF HEALTH

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Arkansas PRAMS  Component A PRAMS survey data can be used to improve public health by improving the health of mothers and their infants. The data helps us to understand mothers' experiences and behaviors that affect their health and the health of their infants. The long-term goal of the Arkansas Pregnancy Risk Assessment Monitoring System (PRAMS) survey is to reduce infant mortality and morbidity. The specific objectives of the Arkansas PRAMS program in meeting these goals are the following: 1) Collect population-based data of high scientific quality on topics related to pregnancy and early infancy, 2) Promote the use and increase the visibility of the PRAMS data to encourage translation of the data into programs, policies, or strategies to improve maternal and child health, 3) Analyze and disseminate PRAMS data to inform the healthcare community about behaviors and experiences that affect infant and maternal health, and 4) Provide data and technical assistance to organizations or programs interested in using PRAMS data. Arkansas PRAMS has met these objectives by: 1) Providing non-CDC funding and in-kind personnel to carry out the day-to-day PRAMS operations, including funding to pay contractors for both the telephone surveys and mail survey data entry, 2) Improving mail operations to encourage mothers to complete the survey and increase response rates through various strategies such as increasing incentives, launching a media campaign, and adding a third mail out, 3) Developing and disseminating PRAMS reports (e.g., chart books, surveillance reports) to the health community, 4) Collaborating with internal (e.g., Maternal and Child Health Branch/Arkansas Department of Health) and external programs (e.g., Arkansas March of Dimes, University of Arkansas for Medical Sciences) to analyze the PRAMS data for programmatic purposes, and 5) Responding to data requests from and providing technical assistance to a variety of internal and external programs that have a mission related to maternal and child health.

PI_NAMEs: DE GRAFT-JOHNSON, LETITIA  (contact)

PROJECT_TITLE: RFA-DP-21-001 Pregnancy Risk Assessment Monitoring System (PRAMS) Grant


ORG_CITY: CONCORD

ORG_NAME: NH STATE DEPT/HLTH STATISTICS/DATA MGMT

ORG_STATE: NH

PHR: Component A: Core Surveillance – Pregnancy Risk Assessment Monitoring System PD/PIs: Paulette Valliere, MPH; David Laflamme, PhD, MPH New Hampshire Division of Public Health Services Public Health Relevance Statement The public health relevance of PRAMS consists in the collection and analysis of data which is translated to explain and provide an understanding of maternal and child health needs, behaviors and outcomes. This is critical to the design and implementation of programs and policies to improve health. PRAMS data fill a crucial information gap and provide standardized data which can be compared to and aggregated with the data from other PRAMS projects across the United States.

PI_NAMEs: NYAMASEGE, CAROLYN KEMUNTO (contact)


ORG_CITY: PORTLAND

ORG_NAME: PUBLIC HEALTH SERVICES

ORG_STATE: OR

PHR: Oregon PRAMS Project Narrative The Pregnancy Risk Assessment Monitoring System (PRAMS) surveys mothers of 2-3 month old babies about their and their child’s health. By answering questions about health and behavior before, during, and after pregnancy, PRAMS participants help us learn more about challenges facing Oregon mothers and babies. We use this information to improve programs, create policy, and support families throughout the state.

PI_NAMEs: WILCOX, CATE S (contact)

PROJECT_TITLE: DP21-001 Pregnancy Risk Assessment Monitoring Systems (PRAMS), Component A: Core Surveillance


ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT STATE DEPT OF PUBLIC HEALTH

ORG_STATE: CT

PHR: Project Narrative The Connecticut (CT) Pregnancy Risk Assessment Monitoring System (PRAMS) is designed to provide the Department of Public Health (DPH) with important data about maternal health, experiences, and behaviors during the perinatal period; advance knowledge about risk and protective factors among CT mothers; and investigate the associations between these factors and birth outcomes and maternal and infant health. CT PRAMS data will be integrated into efforts to address state maternal and child health priorities, as well as statewide plans and initiatives to reduce low birth weight, preterm birth, infant mortality, and health disparities.

PI_NAMEs: MORIN, JENNIFER  (contact)

PROJECT_TITLE: DP21-001 Component A (Core Surveillance): Connecticut Pregnancy Risk Assessment Monitoring System (PRAMS)


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Narrative Cells in the developing embryo need cues from their environment to instruct them what cell type to become or when to start or stop growing and dividing. Here we will study how cells in the early mammalian embryo interpret such cues, focusing on the role of mechanical inputs, and how they process this information through the activity of the conserved signaling effector Yes-associated protein (YAP), to make an informed decision about the type of cell they should become. As mis-regulation of YAP activity is known to be frequently associated with malignant tumor formation, our work will reveal important insights into the regulation of this pathway during normal development, and serve as a basis for understanding how it goes awry in cancer.

PI_NAMEs: POSFAI, ESZTER  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Affect;Apoptosis;Automobile Driving;Behavior;Biocompatible Materials;Biological Models;cell behavior;Cell Communication;Cell Fate Control;cell fate specification;Cell Lineage;Cell Physiology;Cell Polarity;Cell Shape;cell type;Cells;Color;Complement;Complex;Coupled;Coupling;Cues;Cytoplasm;Data;Development;Embryo;embryo membrane;Embryonic Development;Environment;Epithelium;Event;experience;experimental study;Extracellular Matrix;Failure;Fluorescence Recovery After Photobleaching;Future;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Genetic;genetic approach;genome editing;Geometry;Image;Individual;Inner Cell Mass;insight;Instruction;Joints;Kinetics;Light;Link;Liquid substance;Maintenance;Malignant Neoplasms;Measurement;Measures;mechanical force;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Microscopy;mimetics;Modeling;Molecular;Monitor;Morphogenesis;mouse model;Mus;Nuclear;Nuclear Export;Oocytes;Organ;Pathway interactions;Pattern;Placenta;Play;Positioning Attribute;Pre-implantation Embryo Development;preimplantation;Process;progenitor;programs;Proliferating;Property;Protein Dynamics;Proteins;regenerative;Regulation;Reporter;Resolution;response;Rest;Role;Sampling;segregation;Signal Pathway;Signal Transduction;Signaling Protein;Specific qualifier value;stem;Structure;Surface;synergism;System;Testing;Time;Tissues;tool;Transcription Coactivator;transcription factor;transcriptomics;Transducers;transmission process;Visualization;Work

PROJECT_TITLE: Geometric and mechanical control of developmental Yap signaling

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ORG_CITY: DES MOINES

ORG_NAME: IOWA STATE DEPT OF PUBLIC HEALTH

ORG_STATE: IA

PHR: RFA-DP-21-001 Research Strategy Component A – Core Surveillance Iowa PRAMS Surveillance Project Component A – Core Surveillance Project Narrative PRAMS stands for the Pregnancy Risk Assessment Monitoring System and is a survey sent by the Iowa Department of Public Health to selected mothers 2-6 months after the birth of their child. The survey asks women about their attitudes and experiences before, during, and shortly after pregnancy. Iowa’s priorities for use of PRAMS data include reducing racial disparities in maternal and infant outcomes and reducing infant morbidity and mortality. See Iowa’s Research Plan Project Narrative uploaded on the PHS 398 Research Plan Form, #3 Research Strategy.

PI_NAMEs: PHAM, JENNIFER  (contact)

PROJECT_TITLE: DP21-001 Iowa Pregnancy Risk Assessment Monitoring System (PRAMS) Surveillance Project


ORG_CITY: AUGUSTA

ORG_NAME: MAINE STATE DEPT/HEALTH/HUMAN SERVS

ORG_STATE: ME

PHR: Maine Pregnancy Risk Assessment Monitoring System (Maine PRAMS) – Component A Project Narrative The Maine Pregnancy Risk Assessment Monitoring System (Maine PRAMS) intends to collect data on maternal experiences and behaviors before, during, and after pregnancy to better inform healthcare, social services, and communities. Maine PRAMS aims contribute to the current resources of maternal and infant health data in the state of Maine and on the national stage. This data is collected with the ultimate purposes of infusing policy and practice to improve the health and well-being of Maine’s mothers and infants and decrease the maternal and infant mortality and morbidity rate in Maine.

PI_NAMEs: HAGGAN, KIM  (contact)

PROJECT_TITLE: DP21-001 Maine Pregnancy Risk Assessment Monitoring System - Component A: Core Surveillance


ORG_CITY: COLUMBIA

ORG_NAME: SOUTH CAROLINA DEPARTMENT OF PUBLIC HEALTH

ORG_STATE: SC

PHR: SOUTH CAROLINA (SC) PRAMS PROGRAM NARRATIVE The data collected and analyzed as part of the SC PRAMS program will be used to assess the overall health of mothers and infants in SC, and to inform and evaluate programs charged with improving the health of this population. The health of mothers and infants is a key component of overall public health.

PI_NAMEs: SHEALY, KRISTEN  (contact)

PROJECT_TITLE: DP21-001 SC Pregnancy Risk Assessment Monitoring System (SC PRAMS)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative The project seeks to gain a quantitative understanding of the molecular networks within cells that control the generation of key progenitor cell types that arise during human brain development. To do so, it will develop modeling and computational tools as well as test these tools on human embryonic stem cell lines. In the longer term, a quantitative understanding of the circuits within cells that control development will allow us to uncover mechanisms underlying developmental disease.

PI_NAMEs: RAMANATHAN, SHARAD  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Bar Codes;Biochemical;Biological Assay;Brain;Cell Line;cell type;Cells;Cellular Morphology;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;computerized tools;Computing Methodologies;Congenital Abnormality;course development;CRISPR/Cas technology;Data;Development;developmental disease;directed differentiation;disease model;Ethical Issues;Event;Forebrain Development;Foundations;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;glial cell development;Goals;Guide RNA;Human;human data;human embryonic stem cell;human embryonic stem cell line;human fetus tissue;human stem cells;human tissue;improved;In Vitro;in vivo;Individual;insight;Joints;Lentils - dietary;LHX2 gene;Libraries;machine learning method;Maps;Mathematics;Methods;Midbrain structure;Mitotic;model building;model organism;Modeling;Molecular;molecular marker;Neocortex;neocortical;nerve stem cell;neurodevelopment;Neuroglia;Neurologic;neuroregulation;novel;Organism;Physics;predictive modeling;Probability;progenitor;Prosencephalon;Radial;response;RNA;Role;Signal Transduction;single cell sequencing;SOX11 gene;Statistical Methods;statistics;stem cell differentiation;stem cell fate;stem cells;subventricular zone;success;System;Techniques;Testing;time interval;tool;transcription factor;Viral;WNT Signaling Pathway;Work

PROJECT_TITLE: Determining lineage decisions and gene regulatory networks governing the generation of key progenitor cell types during early human brain development

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: There are currently no effective treatments for tauopathies, such as Alzheimer’s Disease (AD). Uptake and spreading of pathogenic tau is recognized as a key driver of AD pathology, and is primarily mediated by tau's interaction with the cellular receptor LRP1. Molecular dissection of the tau-LRP1 interaction will enable us to devise new therapies for AD.

PI_NAMEs: RAUCH, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Acetylation;Affinity;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amber;Biochemical;Biological;Biological Assay;Brain;Cell Culture Techniques;Cells;Charge;Codon Nucleotides;comparison control;Complex;Cryoelectron Microscopy;density;Deposition;Development;Disease;Disease Progression;Dissection;effective therapy;Electrostatics;Elements;Evaluation;Fluorescence Resonance Energy Transfer;Genetic;Goals;Human;human disease;human induced pluripotent stem cells;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;innovation;insight;Intervention;knock-down;Knowledge;LDL-Receptor Related Protein 1;Learning;Ligands;Link;Lipoprotein Receptor;Lysine;Maps;Mass Spectrum Analysis;Measures;Mediating;Methods;Modeling;Modification;Molecular;Mus;Neurodegenerative Disorders;novel;novel therapeutics;Pathogenicity;Pathologic;Pathway interactions;Phosphorylation;Point Mutation;Post-Translational Protein Processing;prevent;Process;protein aggregation;Protein Isoforms;protein protein interaction;Proteins;Protocols documentation;Publishing;receptor;Regulation;Sampling;Site;Structure;Surface;tau aggregation;tau interaction;tau mutation;tau Proteins;tau-1;Tauopathies;Technology;Testing;therapeutic target;treatment strategy;Ubiquitin;Ubiquitination;unnatural amino acids;unpublished works;uptake;Work

PROJECT_TITLE: Deciphering the Molecular Features Underlying LRP1-Mediated Tau Spread

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Iron regulatory proteins and Argonaute-2 are RNA-binding proteins that respectively coordinate cellular iron regulation and microRNA-mediated regulation, mechanisms essential for the proper execution of early embryonic development. The objective of this project is to dissect the specific roles of post-transcriptional regulation by microRNAs and iron regulatory proteins on cell fate decisions in early mammalian development and to build in vitro and in vivo biosensor platforms to model cellular iron utilization in early mammalian development. A comprehensive understanding of the dynamic relationships of iron regulatory proteins, microRNAs, and their functional targets during this critical developmental window is needed and will provide a roadmap for functional rewiring in stem/progenitor cell-based regenerative therapies.

PI_NAMEs: SANGOKOYA, CAROLYN O (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3' Untranslated Regions;Address;Alleles;Anatomy;Binding;Binding Proteins;Binding Sites;Biosensor;Board Certification;career development;Cell Differentiation process;Cell Fate Control;Cell model;Cells;CRISPR/Cas technology;Critical Pathways;crosslink;Data;Development;Development Plans;Developmental Biology;Embryo;Embryoid bodies;Embryonic Development;embryonic stem cell;Endocytosis;Ensure;Environment;Erythropoiesis;Family;Fibroblast Growth Factor;Five-Year Plans;functional genomics;Future;gastrointestinal;gastrulation;Goals;Grant;Hepatobiliary;High-Throughput Nucleotide Sequencing;Human Development;Immunoprecipitation;In Vitro;in vivo;Iron;Iron Regulatory Protein 1;Iron-Regulatory Proteins;Knowledge;Laboratories;Leadership;Learning;Maps;Mediating;Mentored Clinical Scientist Development Award (K08);Mentors;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;mouse model;multidisciplinary;mutant;neurogenesis;Nucleotides;Operative Surgical Procedures;Organogenesis;Pathologist;Pathology;Pathway interactions;Pattern;Physicians;pluripotency;Post-Transcriptional Regulation;Process;Productivity;profilin;regenerative therapy;Regulation;Reporter;Research;Resolution;RNA-Binding Proteins;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;Specific qualifier value;Statistical Methods;stem cell biology;stem cell differentiation;stem cell fate;Stem cell pluripotency;stem cell self renewal;stem cells;Technical Expertise;Testing;Tissues;tool;Training;Transcript;transcriptome

PROJECT_TITLE: POST-TRANSCRIPTIONAL REGULATION OF CELL FATE IN EARLY MAMMALIAN DEVELOPMENT

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CINCINNATI

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project narrative Transfer RNAs (tRNA) represent one of the most abundant forms of RNA and chemical modifications to tRNA are critical for structure and function. We will investigate tRNA expression and modifications for blood feeding insects to determine their potential role during feeding and reproduction. Understanding tRNA expression patterns and modifications will develop the resources for new research lines that could provide novel targets for vector control and new mechanisms to reduce disease transmission.

PI_NAMEs: BENOIT, JOSH B. (contact);LIMBACH, PATRICK A

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Area;Arthropods;Bacteria;Biochemical;Biological;Biology;Blood;Chemicals;climate change;Codon Nucleotides;Culicidae;Data;Data Set;disease transmission;egg;Enzymes;Eukaryota;Event;experimental study;Fat Body;feeding;Female;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic Transcription;Goals;Hour;Human;Insect Vectors;Insecta;Insecticide Resistance;Life;Life Cycle Stages;Link;male;Methods;Midgut;Modification;novel;Nucleosides;Nutrient;Organ;Organism;Osmosis;Output;Oxidative Stress;Partner in relationship;pathogen;Pattern;Phenotype;Physiological;Physiology;Play;Population;prevent;Process;Production;Protein Biosynthesis;Publishing;Reproduction;reproductive;reproductive organ;Research;Resources;response;Ribonucleosides;RNA;Role;Sampling;sex;Sex Differences;stress tolerance;Structure;System;Testing;Time;Tissue-Specific Gene Expression;Tissues;Transcript;Transfer RNA;transmission process;Untranslated RNA;vector;vector control;Whole Organism;Yeasts

PROJECT_TITLE: tRNA modifications as critical components of insect blood feeding and reproduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Asthma is a common disease that has major impacts on human health, health care costs, and economic well- being. Airway passages are lined by a protective mucus barrier that becomes detrimental in asthma, resulting in impaired mucociliary clearance and disrupted breathing. My research focuses on understanding the specific mechanisms of MUC5AC and MUC5B polymerization and trafficking along the secretory pathway and how they could lead to novel and potentially more selective interventions strategies.

PI_NAMEs: JARAMILLO HERNANDEZ, ANA MARIA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Affect;airway obstruction;Allergic;Anabolism;Asthma;asthma model;Binding;Biology;Breathing;Cell Line;Cells;Collagen;COPII-Coated Vesicles;Cysteine;Cytoplasmic Tail;Data;Diameter;dimer;Dimerization;Disease;disulfide bond;Disulfides;Drosophila genus;Economics;effective therapy;Endoplasmic Reticulum;Exposure to;Fibrinogen;Foundations;Functional disorder;Glycoproteins;Goals;Golgi Apparatus;Health;Health Care Costs;Homeostasis;Homologous Gene;Human;Human Cell Line;Impairment;improved;In Vitro;Individual;Inflammatory;Intervention;knock-down;Knock-in Mouse;lead candidate;Length;Link;Lung;macromolecule;Mediating;Membrane;Molecular;Molecular Chaperones;monomer;mouse model;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;Mucous body substance;Mus;novel;particle;Pathologic;Pathway interactions;Personal Satisfaction;Point Mutation;polymerization;Polymers;Procollagen;Productivity;protein complex;protein folding;Protein Isoforms;Proteins;public health relevance;Publishing;Reporting;Research;Research Personnel;respiratory;Respiratory Disease;respiratory health;Risk;Role;salivary mucins;secretory protein;SH3 Domains;Site;Surface;Testing;Thick;Thinness;trafficking;Training;Translations;Vesicle;vesicle transport;von Willebrand Factor;Work

PROJECT_TITLE: Mucin Biosynthesis and Transport Mechanisms in Respiratory Health and Disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE To implant in the uterus and establish a pregnancy, the cells of the mammalian embryo must first organize into different specialized cell types. Here, we seek to understand the mechanisms that drive these early cell-differentiation processes, as they occur in real time within the living mouse embryo.

PI_NAMEs: PLACHTA, NICOLAS DANIEL (contact)

PROJECT_TERMS: Actins;Apical;Automobile Driving;biophysical properties;biophysical techniques;blastocyst;Cell Communication;cell cortex;Cell Differentiation process;Cell division;Cell Lineage;Cell Nucleus;Cell Polarity;Cell Separation;cell type;Cells;Cytokeratin filaments;Cytoplasm;Cytoskeleton;Data;daughter cell;Development;Elements;Embryo;embryo cell;embryo stage 2;Event;F-Actin;Fetus;Filament;Future;genetic risk factor;Goals;Image;imaging approach;Implant;in vivo;Inherited;Inner Cell Mass;Intermediate Filaments;Interphase;Keratin;Length;Mammalian Cell;Measurement;mechanical force;Mechanics;Microtubules;Mitosis;Modeling;Molecular;molecular asymmetry;Molecular Chaperones;molecular dynamics;mouse development;Movement;Mus;Nonmammalian Embryo;Nuclear;Organism;overexpression;PARD6A gene;Pattern;Placenta;Pregnancy;preimplantation;premature;Process;Proteins;Role;scaffold;segregation;Specific qualifier value;Testing;Time;transcription factor;Uterus;Work

PROJECT_TITLE: Revealing how cytoskeletal dynamics form the early mammalian embryo


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative.  The goal of this geroscience project is to show that a cocktail of drugs targeting well accepted processes of aging will alleviate neuropathology and restore normal cognitive function in a mouse model of Alzheimer's disease (AD). The concept of a drug cocktail that could successfully treat AD would be expected to have a significant impact on the health of patients suffering from early symptoms of dementia and other AD related issues.

PI_NAMEs: DARVAS, MARTIN C;LADIGES, WARREN C (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Acarbose;Age;age effect;Age Months;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-42;Animal Disease Models;anti aging;Anti-Inflammatory Agents;Autophagocytosis;Awareness;Biological Aging;Biological Availability;Biological Process;Blood Vessels;Brain;Caloric Restriction;Cell Physiology;Clinical;Clinical Research;cognitive function;cohort;comparison control;Complex;Dementia;design;Developing Countries;Development;Diet;dietary control;Disease;Drug Combinations;drug repurposing;Drug Targeting;Elderly;Epigenetic Process;Event;Functional disorder;Funding;Gender;Gene Expression;Geropathology;Geroscience;Goals;Grant;Health;Hippocampus;Histone Deacetylase Inhibitor;Homeostasis;Impaired cognition;Impairment;Individual;Inflammation;Insulin;Interest Group;Intervention;intervention effect;Investigation;Lesion;Liver;Metabolism;metabolome;metabolomics;middle age;mimetics;misfolded protein;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;mTOR inhibition;multidisciplinary;Mus;Neurologic;neurological pathology;Neurons;neuropathology;neurovascular;old mice;Outcome;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phenylbutyrates;Physiological;Play;preclinical study;prevent;Process;Proteins;proteostasis;response;Risk;Role;Sampling;screening;Sirolimus;stem cell self renewal;Stress;success;successful intervention;symposium;Symptoms;Systemic disease;Testing;therapy development;Tissues;Toxic effect;United States National Institutes of Health;Vascular Endothelial Cell

PROJECT_TITLE: A geroscience approach for treating Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The goal of this project is to investigate how unusual nucleotides produced by bacteria control their cell physiology in a way that facilitate infections. These nucleotides are produced by bacteria in response to changes in their surroundings, including unfavorable conditions encountered during the course of mammalian infections. The study will be conducted with a bacteria from the genus Enterococcus, which is the 3rd most common cause of infections in hospitalized patients and an emerging public health threat due to the continuous rise of strains that are resistant to most clinically-useful antibiotics.

PI_NAMEs: LEMOS, JOSE A (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Agonist;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Area;Attenuated;Bacteria;bacterial fitness;Binding;biological adaptation to stress;Biological Process;catheter associated UTI;cell envelope;Cell Maintenance;Cell Physiology;Cells;Cellular Metabolic Process;cellular targeting;Characteristics;Clinical;Complex;Cues;Cyclic Nucleotides;Data;Disease;Disinfectants;Enterococcus;Enterococcus faecalis;Enterococcus faecium;Environment;Exposure to;fitness;Functional disorder;Gastrointestinal tract structure;Goals;Growth;Homeostasis;Hospitalization;Hospitals;Human;Immune response;Immune system;Impairment;implantable device;Infection;Innate Immune Response;innovation;insight;interest;Interferon Type I;Investigation;Knowledge;Light;Link;Mechanics;Mediating;Metabolism;Microbial Biofilms;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Nosocomial Infections;novel;Nucleotides;opportunistic pathogen;Osmoregulation;pathogen;Pathogenesis;Pathogenicity;Patients;Phase;Physiological;Play;Process;Production;Proteins;Public Health;rational design;Regulation;Research;Research Design;resident commensals;resistant strain;response;Role;Second Messenger Systems;Signal Transduction;Solid;Stimulus;Stress;stress resilience;Surface;Time;Tissues;trait;Virulence;Work

PROJECT_TITLE: Second Messenger Nucleotides of Enterococcus faecalis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-D(02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

PHR: PROJECT NARRATIVE Twenty five percent of human cancers have mutations in subunits of the chromatin remodeling SWI/SNF complex. This research proposal describes an innovative approach to study the tumor suppressor activity of SMARCB1, a core member of the complex, which is lost in nearly all cases of an aggressive and lethal pediatric cancer named malignant rhabdoid tumor. The long-term goals of this project are to determine both how SMARCB1 regulates the SWI/SNF complex composition and targeting, and how SMARCB1 affects higher-order chromatin structure, in order to better understand how cancers arise when the complex is mutated.

PI_NAMEs: WANG, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: 3-Dimensional;Affect;Architecture;Award;Binding;Biochemical;Biological Assay;Biology;cancer genome;Catalogs;Child;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;Development;Enhancers;Epigenetic Process;epigenome;epigenomics;experimental study;Genetic Transcription;Genetically Engineered Mouse;genome sequencing;genome-wide;Genomics;Goals;Heterogeneity;High-Throughput Nucleotide Sequencing;Higher Order Chromatin Structure;Histones;Human;infancy;innovation;insight;Investigation;Label;Link;loss of function mutation;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;member;Molecular;Mutate;Mutation;Names;novel;Oncogenic;Prevalence;programs;protein complex;protein protein interaction;Proteins;Recurrence;Research;Research Proposals;Residual state;Rhabdoid Tumor;Role;Series;SMARCB1 gene;Structure;SWI/SNF Family Complex;Techniques;Technology;Testing;Tissues;transcription factor;transcriptome;tumor;Tumor Cell Line;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: SMARCB1 regulated SWI/SNF complex function in Malignant Rhabdoid Tumors

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: NARRATIVE The goal of this research is to elucidate mechanisms employed by pathogenic microorganisms to combat the mammalian immune response through NO and NOx detoxifying processes. In many cases, redox active metal-containing proteins known to be over-expressed in stress conditions lack assigned physiological functions despite being structurally defined. Kinetic and molecular spectroscopy studies are essential components to the identification and understanding of their catalytic mechanisms.

PI_NAMEs: MOENNE-LOCCOZ, PIERRE  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Aerobic;Binding;Biochemical;Biochemistry;Biological Process;Biology;Catalysis;cofactor;combat;Complex;Conversion disorder;Data;denitrification;Detoxification Process;Dioxygen;Dissociation;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Equation;experimental study;Exposure to;Flavins;Goals;Health;Heme;Hemeproteins;Hemerythrin;Hemoglobin;Human;Immune response;Infection;Inorganic Chemistry;Investigation;Ions;Iron;Kinetics;Ligands;Macrophage;metalloenzyme;Metals;microbial;microorganism;Molecular;mycobacterial;Mycobacterium kansasii;Mycobacterium tuberculosis;Nitrates;Nitric Oxide;nitric oxide reductase;Nitrites;Nitrogen;nitrosative stress;Nitrous Oxide;novel;Organism;overexpression;Oxidases;Oxidation-Reduction;Oxidative Stress;Oxygen;Oxygenases;Pathogenicity;Pathway interactions;Physiological;Play;Process;Proteins;Protons;Reaction;Reactive Nitrogen Species;Research;response;Roentgen Rays;Role;Route;Site;Site-Directed Mutagenesis;Sodium Chloride;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;stoichiometry;Stress;structural determinants;Structure;Surveys;System;Techniques;Theoretical model;Time;Tuberculosis;Uncertainty;X-Ray Crystallography

PROJECT_TITLE: Nitrosative stress and NO detoxifying reaction mechanisms in microbial nonheme diiron proteins

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Precision Medicine;Prevention;Rare Diseases;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative One of the biggest challenges in rare disease is accuracy and timeliness of patient diagnosis. Genetic risk predictions can improve diagnosis, with particular clinical utility in the specific setting where large barriers to diagnosis exist – such in the case of the rare sleep disorders Narcolepsy and Circadian Rhythm Sleep Wake Disorders. To address the challenge of timely patient diagnosis in Narcolepsy and Circadian Rhythms Sleep Wake Disorders, we propose to leverage large exome sequence repositories to generate rare variant risk scores, expand the current known common polygenic scores to multiple genetic ancestries, and ultimately test the ability of both the rare and common polygenic scores to address misdiagnosis of Narcolepsy and Circadian Rhythm Sleep Wake Disorders in large-scale hospital database with the goal to integrate flags in patient records.

PI_NAMEs: LANE, JACQUELINE MARIE (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;Autoimmune;Awareness;biobank;Catalogs;circadian;Circadian Rhythms;Clinic;Clinical;cohort;Complex;Computer software;Databases;Diagnosis;Diagnostic;Diagnostic tests;Disease;disease-causing mutation;disorder risk;Early Diagnosis;Early identification;early screening;European ancestry;Evaluation;exome;exome sequencing;Face;Genes;Genetic;genetic predictors;Genetic Risk;genetic variant;genome sequencing;genome wide association study;Goals;health disparity;health inequalities;Healthcare;Healthcare Systems;Hospitals;Human Genetics;improved;Individual;Inequality;Insurance Coverage;large-scale database;medical specialties;Medicine;Mental Depression;Narcolepsy;novel;Patients;people of color;personalized predictions;Pharmaceutical Preparations;Phase;Phenotype;polygenic risk score;Population;Primary Care Physician;Process;Rare Diseases;rare variant;Records;repository;Risk;Risk Factors;Risk Marker;risk prediction;risk variant;routine screening;screening;Sleep;sleep behavior;Sleep Disorders;Sleeplessness;Testing;timeline;trait;Unnecessary Procedures;Variant;Visit;Woman;Work

PROJECT_TITLE: Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.


ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This proposal will define the novel molecular mechanisms that govern the targeting of G protein-coupled receptors to the functional destination. These receptors regulate a variety of cell functions under the physiological and pathological conditions and are the most heavily investigated drug targets. The successful completion of these studies may create new avenues for drug design and treatment of diseases involving aberrant trafficking and function of G protein-coupled receptors.

PI_NAMEs: WU, GUANGYU  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Adrenergic Receptor;alpha helix;Area;Binding Proteins;Biochemical;Cell membrane;Cell Physiology;Cell surface;Destinations;Disease;Drug Design;Drug Targeting;Ear;Endoplasmic Reticulum;G-Protein-Coupled Receptors;genetic regulatory protein;Goals;Golgi Apparatus;Hormones;Imaging Techniques;insight;live cell imaging;Membrane Proteins;Modeling;Molecular;novel;Pathologic;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Post-Translational Protein Processing;programs;protein function;Proteins;prototype;receptor;Regulation;Research;response;Rod;Role;Route;Sorting;structural determinants;targeted treatment;trafficking;Ubiquitination

PROJECT_TITLE: GPCR anterograde trafficking

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: SAINT LUKE'S HOSPITAL

ORG_STATE: MO

PHR: PROJECT NARRATIVE Out-of-hospital cardiac arrest (OHCA) is a leading cause of death in the U.S., affecting 350,000 individuals annually, and is associated with high mortality and morbidity. The proposed RED- CASO (Reducing Ethnic-racial Disparities in Cardiac Arrest Survival Outcomes) study will identify best resuscitation practices at EMS agencies with the highest survival rates for OHCA, especially at EMS agencies that work in majority Black or Hispanic communities. This research is relevant to the mission of the National Heart Lung and Blood Institute because it will identify best practices, improve outcomes, and has the potential to reduce racial and ethnic disparities in survival for a condition with high public health burden .

PI_NAMEs: CHAN, PAUL SHEUNG-YAN (contact);GIROTRA, SAKET

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 911 call;Accident and Emergency department;Address;Administrator;Adopted;Adoption;Affect;American Heart Association;Baseline Surveys;Black Populations;Black race;Cardiology;Cardiopulmonary Resuscitation;care systems;Caring;Cause of Death;Censuses;Centers for Disease Control and Prevention (U.S.);Circulation;Communities;community engagement;Community Services;cost;Data;design;disparity reduction;Effectiveness;Emergency medical service;Emergency Medicine;emergency settings;Ensure;Epidemiology;ethnic disparity;Ethnic Origin;Face;Fire - disasters;first responder;Focus Groups;Foundations;Future;Goals;health equity;health equity promotion;Heart Arrest;Hispanic;hispanic community;Hispanic Populations;Hospitals;Immigration;improved;improved outcome;Individual;innovation;insight;Interview;Knowledge;Language;Life;Low income;Medical Staff;Methodology;Methods;Mission;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Native Americans;Neighborhoods;novel;out-of-hospital cardiac arrest;Outcome;Outcome Study;Paramedical Personnel;Patient-Focused Outcomes;Patients;Peer Review;Persons;Police;Policies;Practice Guidelines;Pre-hospital setting;Pre-hospitalization care;premature;Process;Public Health;Publications;racial disparity;Registries;Research;Research Methodology;Research Personnel;Resources;response;Resuscitation;Risk Adjustment;routine practice;Sampling;Site;Site Visit;Surveys;survival outcome;Survival Rate;System;Time;Universities;Variant;Work

PROJECT_TITLE: Reducing Ethnic-racial Disparities in Cardiac Arrest Survival Outcomes (RED-CASO)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Loss-of-function mutations in the post-synaptic scaffolding protein encoded by the SHANK3 gene are among the most common monogenic causes of neurodevelopmental disorders. This proposal aims to determine its post-translational regulation to add fundamental knowledge of synaptic development and physiology and develop treatment avenues for individuals with SHANK3 mutations.

PI_NAMEs: HOLDER, JIMMY L (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: 2 year old;Address;Ankyrin Repeat;autism spectrum disorder;Behavior;Behavioral;Biochemical;Biochemistry;Brain;candidate identification;Caregivers;casein kinase;casein kinase I;Cells;Clinical;Cognitive;Complex;Data;Development;Developmental Delay Disorders;Disease;dosage;Economics;effective therapy;Elements;Epilepsy;F-Box Proteins;family burden;Future;gain of function mutation;Gene Dosage;Gene Mutation;Genes;Genetic;Genomics;Goals;Half-Life;Heterozygote;Human;improved;In Vitro;in vivo;Individual;Induced Neurons;inhibitor;insight;Intellectual functioning disability;Knockout Mice;Knowledge;Length;Life;loss of function mutation;MAPK1 gene;Measures;Mediating;member;Methods;Mission;Molecular;multicatalytic endopeptidase complex;Mus;Mutant Strains Mice;Mutation;National Institute of Neurological Disorders and Stroke;Neurodevelopmental Disorder;Neurons;neurophysiology;Pathogenicity;Patients;personalized medicine;pharmacologic;Phelan-McDermid syndrome;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Post-Translational Regulation;postsynaptic;pre-clinical;Pre-Clinical Model;protein complex;protein degradation;Proteins;Publishing;Regulation;repaired;Reporting;Rodent Model;Scaffolding Protein;Sequence Deletion;severe intellectual disability;Symptoms;Synapses;synaptogenesis;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Ubiquitination;Work

PROJECT_TITLE: Harnessing post-translational regulation of SHANK3 as a boosting strategy for Phelan-McDermid syndrome


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Cystic fibrosis (CF) remains one of the most common, life-limiting genetic disorders due to chronic bacterial lung infections that do not respond to traditional antibiotic therapy. The proposed research will achieve a thorough understanding of how the immune system fails to respond to bacterial infections in CF in order to develop targeted therapies to prevent life- limiting bacterial lung infections. The proposal is relevant to public health and the NIH's mission as the findings will impact the treatment and understanding of immunodeficiencies and lung diseases associated with chronic bacterial infections.

PI_NAMEs: KOPP, BENJAMIN T (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: AKT inhibition;Antibiotic Therapy;Antibiotics;Autophagocytosis;Autophagosome;Bacteria;Bacterial Infections;Burkholderia cepacia;Chronic;Chronic Granulomatous Disease;chronic infection;Clinical;combat;CRISPR/Cas technology;Cysteamine;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;drug resistant pathogen;endoplasmic reticulum stress;Functional disorder;functional loss;Genetic;Genetic Diseases;Goals;Host Defense;Human;Immune response;Immune system;Immune System Diseases;immunodeficiency;Impairment;improved;Infection;Inflammation;innovation;Ions;Knock-out;Knowledge;Life;Lung;Lung Diseases;Lung infections;Macrophage;Mediating;misfolded protein;Mission;monocyte;Mutate;Mutation;NADPH Oxidase;novel;novel therapeutic intervention;Outcome;pathogen;Pathway interactions;Pharmaceutical Preparations;pharmacologic;prevent;Production;protein aggregation;protein misfolding;Proteins;Proto-Oncogene Proteins c-akt;Pseudomonas aeruginosa;PTEN gene;Public Health;Publishing;Reactive Oxygen Species;recruit;Research;response;restoration;Role;Signal Pathway;Signal Transduction;Signaling Protein;Sputum;Staphylococcus aureus;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Translating;United States National Institutes of Health;Virulent;Work

PROJECT_TITLE: The role of CFTR during macrophage-mediated killing of bacteria

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: HARARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: ZVITAMBO INSTITUTE FOR MATERNAL AND CHILD HEALTH RESEARCH

PHR: Project narrative HIV-exposed uninfected (HEU) children in sub-Saharan Africa have higher mortality, more illness episodes, poorer growth and impaired cognitive development in the first 2 years of life compared to HIV-unexposed children. It is important now to evaluate long-term growth, health, physical and cognitive function as HEU children start school, and to identify the network of factors in early life that drive these health disparities. This would identify targets for intervention in early life to improve long-term health, growth and human capital in HEU children, so that this vulnerable population can survive, thrive and reach their full potential.

PI_NAMEs: PRENDERGAST, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 12 year old;2 year old;7 year old;Activities of Daily Living;Acute;Africa South of the Sahara;Age;Age disparity;Anti-Retroviral Agents;antiretroviral therapy;Assessment tool;Biological;Biological Markers;Birth;Body Composition;burden of chronic illness;Child;Childhood;Chronic;Clinic Visits;Clinical;cluster trial;co-infection;Cognition;cognitive development;cognitive function;cohort;comorbidity;data repository;Data Set;Disease;Disparity;Disparity population;Early identification;early life exposure;early pregnancy;efficacy trial;Enrollment;Environmental Exposure;Event;Exposure to;Fatty acid glycerol esters;follow-up;Functional disorder;Goals;Grant;Growth;Growth and Development function;Health;health difference;health disparity;HIV;Hospitalization;human capital;Hygiene;Impaired cognition;Impairment;improved;infant nutrition;Infection;Inflammation;Inflammatory;insight;Intervention;Life;Life Cycle Stages;Link;Low Birth Weight Infant;maternal depression;Measurement;Medical History;Mental Health;Metabolic;Metadata;mortality;Mothers;neurodevelopment;Neuropsychology;Organ;Outcome;Pharmaceutical Preparations;Phase;Phase Transition;Phenotype;physical conditioning;Physical Function;poor health outcome;Poverty;Pregnancy;Prevention;Prevention therapy;Process;prospective;recruit;Risk Factors;Rural;Sanitation;School-Age Population;Schools;Sentinel;sex;social;Specimen;Subgroup;Techniques;Thinness;Time;Update;Vertical Disease Transmission;Village Health Workers;Viremia;Vulnerable Populations;Zimbabwe

PROJECT_TITLE: Clinical outcomes of HIV-exposed uninfected children during mid-childhood in rural Zimbabwe


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Patient Safety;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARATIVE Talaromyces marneffei is a fungus endemic in Southeast Asia that kills one in three infected persons with a compromised immune system. The current culture diagnosis is poorly sensitive and is protracted leading to delayed treatment and poor patient outcomes. In this application we propose to validate multiple new non-culture tests for rapid diagnosis and to test whether human infection is a result of airborne exposure to guide disease control and management.

PI_NAMEs: LE, THUY  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Air;air sampling;Amphotericin B;antigen detection;Antigens;Asia;biobank;Biological Assay;Blood;Blood specimen;burden of illness;Cause of Death;Cessation of life;China;Clinical;cohort;Communities;Country;Cryptococcosis;data quality;design;Detection;detection assay;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;differential expression;Disease;Disease Management;Disease Reservoirs;disease transmission;disorder control;disorder prevention;Early Diagnosis;Epidemiology;epidemiology study;Exposure to;feature selection;Foundations;Funding;fungus;Gene Expression Profile;Genes;Genetic Transcription;Geography;Goals;high risk;HIV;Hot Spot;Human;human disease;Iatrogenesis;Immigration;Immune response;Immune system;Immunoglobulin G;Immunoglobulin M;Immunosuppression;improved;Incidence;Individual;Infection;innovation;International;Itraconazole;Knowledge;Lead;Link;Lung infections;Methods;Modality;Morbidity - disease rate;mortality;Neoadjuvant Therapy;novel;Opportunistic Infections;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Persons;point-of-care diagnostics;Population;Positioning Attribute;Predictive Value;Prevalence;programs;prospective;Province;Public Health Applications Research;randomized trial;rapid diagnosis;rapid test;recruit;Research;Residencies;Respiratory Signs and Symptoms;Respiratory Tract Infections;Risk;Sampling;Sampling Studies;screening;seroconversion;Seroprevalences;Southeastern Asia;Specificity;Talaromyces;Testing;Thailand;Time;Transcript;transcriptome sequencing;transcriptomics;transmission process;Travel;treatment guidelines;Tropical Medicine;Tube;Tuberculosis;United States National Institutes of Health;Urine;Vietnam;Whole Blood

PROJECT_TITLE: Tropical Medicine Research Center for Talaromycosis in Vietnam


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Infectious Diseases;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The challenge in curing HIV-1 is the persistence of a latent viral reservoir (LVR) that primarily resides in resting CD4+ (rCD4) T cells despite effective antiretroviral therapy (ART). The proposed study will evaluate the LVR spatially, genetically, phenotypically, and immunologically in multiple compartments among people living with HIV, undergoing renal transplantation, and receiving different T cell induction strategies prescribed for prophylactic allograft rejection. These studies will provide critical information on feasibility and mechanisms of potential HIV cure strategies by modeling re-seeding of viral populations in allograft and lymphoid tissues and determining driving mechanisms of clonal proliferation.

PI_NAMEs: SMITH, MELISSA LAIRD;TOBIAN, AARON A (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: allograft rejection;Allografting;Antigens;antiretroviral therapy;Antithymoglobulin;Atlases;Automobile Driving;basiliximab;Binding;Biological Assay;Biological Sciences;Blood;CD4 Positive T Lymphocytes;Cell Separation;Cells;Circulation;Clinical;Clonal Expansion;Clonality;cohort;Cytomegalovirus;Data;DNA;Freezing;Half-Life;HIV;HIV-1;Human Herpesvirus 8;Immune;Immunofluorescence Immunologic;Immunologic Markers;Immunologics;Immunosuppression;Immunosuppressive Agents;Individual;Influenza;insight;integration site;interest;Interleukin 2 Receptor;Interruption;Kidney;kidney allograft;Kidney Transplantation;laser capture microdissection;latent HIV reservoir;lymph nodes;Lymphoid Cell;Lymphoid Tissue;Maintenance;Measurement;Measures;Metadata;migration;Modeling;multimodality;next generation sequencing;novel;Organ;organ transplant recipient;Organ Transplantation;Outcome;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;Positioning Attribute;post-transplant;Process;Proliferating;promoter;prophylactic;Proviruses;Resolution;Rest;Sampling;Simplexvirus;single molecule;Site;Solid;Source;Structure of germinal center of lymph node;T cell response;T-Cell Depletion;T-Cell Proliferation;T-Lymphocyte;Time;Tissue Sample;Tissues;Transplantation;Viral;Viral reservoir;Virus;Virus Latency

PROJECT_TITLE: T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartments

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The correct duplication of genetic information encoded in DNA is essential for cell growth and survival, and dysregulation of this process is linked to human diseases such as cancer. This proposal aims at uncovering mechanisms that control DNA replication onset in multicellular organisms at a molecular and structural level. The knowledge gained from this work will be important for advancing our understanding of disease mechanisms related to DNA replication and for developing novel therapeutic strategies.

PI_NAMEs: BLEICHERT, FRANZISKA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Basal Cell Nevus Syndrome;Binding;Binding Proteins;Biochemical;biochemical model;Biological Assay;cell growth;Cell Proliferation;Cell Survival;Cells;Chromatin;Chromosomal Duplication;cofactor;Complex;Cryoelectron Microscopy;Data;Dedications;Deposition;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Sequence;Dwarfism;Environment;Eukaryota;Event;Failure;genetic information;Genomic Instability;Genomics;Goals;Growth;helicase;human disease;In Vitro;in vivo;Knowledge;Label;Laboratories;Learning;Licensing;Life;Link;Maintenance;Malignant Neoplasms;Mediating;Modeling;Molecular;Motor;Mutation;novel;novel therapeutic intervention;Nucleosomes;Organism;origin recognition complex;Outcome;Peptide Initiation Factors;Positioning Attribute;Process;Proteins;recruit;Regulation;Replication Initiation;Replication Origin;Research;Research Proposals;Saccharomyces cerevisiae;Saccharomycetales;Site;Specific qualifier value;Structure;System;Techniques;Testing;Work;Yeast Model System

PROJECT_TITLE: Mechanisms for recruitment and function of metazoan replication initiation factors

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Diverse physiological processes depend upon movement of protein and lipid molecules within and between cellular membranes. Defects in these crucial membrane trafficking pathways drive a variety of human diseases, including cancers and serious neurological disorders like Alzheimer's, Parkinson's, and the spastic paraplegias. We study molecular mechanisms of vesicular and tubular coat assembly and regulation on membranes to ensure vital cargo molecules are delivered to the correct cellular destinations in a timely manner.

PI_NAMEs: JACKSON, LAUREN PARKER (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Affinity;Alzheimer's Disease;Binding;Biochemical;biophysical techniques;Capsid Proteins;Cell Line;Cellular biology;Cellular Membrane;Clathrin;Coat Protein Complex I;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Data;Defect;Destinations;Ensure;Event;Experimental Designs;Family;genetic regulatory protein;Goals;Health;Human;human disease;insight;Integral Membrane Protein;Link;Lipids;Malignant Neoplasms;Membrane;Membrane Lipids;Methods;model organism;Molecular;Molecular Structure;Movement;Nervous System Disorder;Parkinson Disease;Pathway interactions;Phenotype;Physiological Processes;polypeptide;protein complex;protein protein interaction;protein transport;Proteins;Regulation;SNAP receptor;Spastic Paraplegia;Structural Models;Testing;tool;trafficking;Tubular formation;Vesicle;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of coat assembly and regulation in membrane trafficking pathways

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

PHR: Project Narrative  The molecular cause of myotonic dystrophy type 1 is known to be a toxic expanded CUG-repeat RNA (CUGexp RNA) that forms ribonucleoproteins (RNPs) that localize in nuclei of skeletal muscle myofibers. The nature of the CUGexp RNP is poorly characterized. The goal of this project is to use proximity labeling to identify the protein and RNA components that contribute to the complex dynamics of the CUGexp RNA RNP and the pathological impact on skeletal muscle.

PI_NAMEs: COOPER, THOMAS A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3' Untranslated Regions;Accounting;Address;Adult;Affect;Alleles;Applications Grants;Binding;Binding Proteins;Biotinylation;Cell Line;Cell Nucleus;Cells;Chimeric Proteins;Complex;CUG repeat;Equilibrium;Family;Fluorescent in Situ Hybridization;Foundations;gain of function;Genes;Genetic Transcription;Goals;Guide RNA;Hereditary Disease;Homeostasis;Human;Image;Individual;insight;Investigation;knock-down;Knowledge;Label;Link;loss of function;Mass Spectrum Analysis;Mediating;Messenger RNA;Molecular;Molecular and Cellular Biology;mortality;mouse model;Muscle Cells;Muscular Atrophy;Muscular Dystrophies;mutant;Myoblasts;Myotonic Dystrophy;Myotonic dystrophy type 1;Nature;new therapeutic target;novel;Nuclear;Nuclear Structure;paralogous gene;Pathogenesis;Pathogenicity;Pathologic;Physiological;Proteins;Ribonucleoproteins;RNA;RNA Folding;RNA Processing;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle weakness;Structure;Tetanus Helper Peptide;Therapeutic;therapeutic target;tissue fixing;Tissue Sample;Tissues;Toxic effect;United States;United States National Institutes of Health;Validation

PROJECT_TITLE: Identification of components and mechanisms regulating expanded CUG-repeat RNP complexes in Myotonic Dystrophy Type 1 muscle cells

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Cardiovascular;Childhood Injury;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Heart Disease;Intellectual and Developmental Disabilities (IDD);Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PHR: PROJECT NARRATIVE Prenatal alcohol exposure is a key factor contributing to abnormal heart development and is associated with various cardiac anomalies with serious long-term complications in adulthood. This study aims to discover novel molecular mechanisms and potential therapies to control the detrimental effect of alcohol exposure on cellular and functional properties of heart cells using human stem cell model.

PI_NAMEs: XU, CHUNHUI  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acceleration;Adult;Affect;Alcohol consumption;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;Alcohols;Animal Model;Anti-Arrhythmia Agents;Antioxidants;Apoptosis;appropriate dose;Arrhythmia;Calcium;Cardiac;Cardiac Myocytes;cardiac repair;Cardiotoxicity;Cell Death;Cell model;Cells;Chemicals;Clinical;clinically relevant;Complement;Complex;congenital heart abnormality;Consumption;cytokine;cytotoxicity;Development;Dose;effective therapy;Effectiveness;Embryonic Development;Engineering;Ethanol;Ethanol toxicity;Event;Fetal Alcohol Exposure;Fetus;Gene Expression;Genes;Goals;Growth;Growth and Development function;Heart;heart cell;heart defect;heart disease risk;Heart Diseases;heart function;Heart Injuries;High Risk Woman;high throughput screening;high throughput technology;high-throughput drug screening;Human;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;Impairment;In Vitro;Infant Mortality;Inflammation;Inflammatory;interest;Investigational Therapies;Ion Channel;Ischemia;Libraries;Life;Link;Machine Learning;Modeling;Molecular;Myocardial dysfunction;National Institute on Alcohol Abuse and Alcoholism;Natural regeneration;new therapeutic target;novel;novel therapeutics;nuclear factor-erythroid 2;Organ;Oxidative Stress;Pathologic;Phenotype;Physiological;Pilot Projects;Play;Proliferating;Property;Protective Agents;Response Elements;Risk Factors;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Sarcoplasmic Reticulum;Signal Transduction;small molecule;small molecule libraries;stem cell model;stem cells;Stromal Cell-Derived Factor 1;Structure;System;targeted treatment;Technology;Testing;Time;Tissues;TNF gene;Toxic effect;transcription factor;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Alcohol-induced cardiac injury and repair in human induced pluripotent stem cell model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: FRESNO

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

PHR: Project relevance: This project will contribute to the characterization of novel chalcone nematicidal agents needed to control parasitic nematodes in animals (including humans) and plants. Therefore, developing new nematicidal agents and understanding their mechanism of action is of paramount importance for human health.

PI_NAMEs: CALDERON-URREA, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Agriculture;Animals;Binding;Caenorhabditis elegans;Cell Death;Cells;Chalcones;cross immunity;deep sequencing;DNA Sequence;Enzymes;experience;Genes;genetic approach;Genetic Complementation Test;Genetic Screening;Goals;Health;helminth infection;Human;Infection;Maps;Medicine;Meloidogyne;microorganism;Molecular;mortality;Mutagens;mutant;Mutation;Nematoda;novel;Parasites;Parasitic nematode;Pathway interactions;Phenotype;Plants;Predisposition;Principal Investigator;programs;Proteins;recruit;Resistance;response;Science;screening;Soil;student training;Testing;tool;transmission process;Underrepresented Populations;uptake;Veterinary Medicine;Work

PROJECT_TITLE: Nematicidal Chalcones: A Genetic Approach to Uncovering the Action Mechanism


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Every animal that develops from a zygote starts life on a path dictated by maternally provided molecules, and subsequent development involves an interplay of maternal and zygotic genetic effects. To understand how these maternal and offspring genomes jointly shape developmental variation and evolution, this research experimentally dissects the contributions of each genome to phenotypic variation within populations of model organisms that vary in their population genetic characteristics.

PI_NAMEs: ROCKMAN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Animal Genetics;Animals;Automobile Driving;Biological Models;Biology;Caenorhabditis;Caenorhabditis elegans;Characteristics;Detection;Development;Developmental Gene;developmental genetics;Developmental Process;Dissection;egg;Embryo;Embryonic Development;Evolution;Exhibits;experience;Experimental Models;experimental study;Gene Expression;Generations;Genes;Genetic;genetic analysis;genetic architecture;Genetic Epistasis;genetic pedigree;genetic variant;Genome;Goals;Heritability;Individual;Life;Maintenance;Maps;Measurement;model organism;Molecular;Mothers;Nematoda;offspring;Partner in relationship;Pattern;Phenotype;Play;pleiotropism;Population;Population Genetics;prevent;Property;Quantitative Genetics;Regulation;Research;Resolution;Resources;Role;Self-Fertilizations;Shapes;System;Testing;trait;transmission process;Variant;Work;zygote

PROJECT_TITLE: Evolutionary Genetics of Animal Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Heart Disease;Immunotherapy;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: The prevalence of dementia in the population is increasing and there are currently no effective therapies or blood-based biomarkers to detect people at high risk. We plan to investigate the role of circulating immune cells as risk factors for dementia, Alzheimer's Disease and cognitive decline and to test whether associations differ in men and women and by genetic risk. This work will yield insights into the relationship between circulating immune cell types and brain aging, identify new biomarkers for cognitive decline, and may reveal novel therapeutic targets aimed at immune cell alterations to prevent and treat dementia.

PI_NAMEs: DOYLE, MARGARET F.;LUNETTA, KATHRYN L;MURABITO, JOANNE M (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Abeta clearance;Adult;Age;age related;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Antibodies;apolipoprotein E-4;Atherosclerosis;Biological;biomarker identification;Blood;blood-based biomarker;Brain;brain health;brain magnetic resonance imaging;Brain region;brain volume;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Case/Control Studies;Cell Aging;cell type;Cells;Cerebrovascular Disorders;Chronic;clinical development;clinical diagnosis;Cognition;Cognitive;Cognitive aging;cohort;Communities;Complex;Dementia;dementia risk;Diabetes Mellitus;Disease;effective therapy;Etiology;gene function;Genes;genetic association;Genetic Predisposition to Disease;Genetic Risk;Goals;Health;high risk;HLA-DR15;Human;Human Genetics;human old age (65+);Hypertension;imaging biomarker;Immune;immune checkpoint blockade;Immune response;Immune system;Impaired cognition;improved;Inflammation;Inflammatory;insight;Interferon Type II;Investigation;Laboratories;Link;Magnetic Resonance Imaging;Measures;Mediating;men;middle age;mild cognitive impairment;Molecular;MRI Scans;multidisciplinary;Nerve Degeneration;neuroimaging marker;neuroimmunology;neuroinflammation;Neurologic;Neuropsychological Tests;new therapeutic target;novel;novel marker;novel therapeutics;offspring;Onset of illness;Outcome;Pathologic;Pathway interactions;Peripheral;Personal Satisfaction;Persons;Phenotype;Play;Population;Predisposition;Prevalence;prevent;Prevention;Process;programmed cell death protein 1;Public Health;Regulatory Pathway;Regulatory T-Lymphocyte;Research;Risk;Risk Factors;Role;Sampling;Science;Senile Plaques;sex;sex risk;Stroke;T cell infiltration;T-Lymphocyte;tau Proteins;Testing;Time;Transgenic Mice;Vascular Cognitive Impairment;vascular factor;vascular risk factor;Woman;Work;β-amyloid burden

PROJECT_TITLE: Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: SURGERY

PHR: Project Narrative For more than 15 million major surgeries performed in the United States annually, surgeons must decide whether the patient should receive close monitoring by specialists in a high-cost intensive care unit (ICU) or intermittent monitoring on a general ward, and when the patient can be safely discharged home. Prior work suggests that artificial intelligence models can identify cases in which doctors have opportunities to make better decisions. The purpose of this project is to design a real-world framework to help doctors make the right decision at the right time so that patients receive the resources they need while recovering safely from major surgery.

PI_NAMEs: LOFTUS, TYLER J (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Admission activity;adverse event risk;Affect;Architecture;artificial intelligence model;Awareness;biomedical informatics;Caring;Classification;Clinical;clinical implementation;Clinical Trials;Cluster randomized trial;Code;Computer software;Computers;cost;Data;data sharing;Decision Making;Decision Support Systems;deep learning;deep learning model;design;Electronic Health Record;Engineering;Ensure;Equity;experimental study;Face;Failure;federated learning;General Ward;Goals;Health;Home;hospital readmission;Hospitalization;Hospitals;Human;implementation science;inpatient surgery;Institution;Intensive Care Units;interoperability;Investigation;Learning;Medical;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;novel;open source;Operative Surgical Procedures;Outcome;Patient Discharge;patient health information;patient oriented;patient privacy;Patient Transfer;Patients;Performance;Postoperative Period;practice setting;Probability;prospective;Prospective Studies;Provider;Recommendation;Reproducibility;Research;Resources;Risk;Risk Adjustment;Series;sociodemographic group;Specialist;Stream;success;Surgeon;System;Testing;Time;Triage;Trust;Uncertainty;United States;usability;user-friendly;Validation;ward;Work

PROJECT_TITLE: Aligning Patient Acuity with Resource Intensity after Major Surgery

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Despite dramatic improvements in outcome for children with acute lymphoblastic leukemia (ALL), up to 25% of children fail frontline therapy and their prognosis is dismal. While patients with prolonged remission have a better prognosis, most eventually succumb to their disease due to the emergence of resistant clones, despite increased intensity of frontline therapies. In this study, we will investigate how the reorganization of 3D chromatin architec- ture contributes to patients’ relapse in acute pediatric leukemia.

PI_NAMEs: TSIRIGOS, ARISTOTELIS  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acute leukemia;Acute Lymphocytic Leukemia;Acute T Cell Leukemia;Address;Affect;Architecture;Binding;cancer initiation;Cancer Patient;Cell Maintenance;Child;Chromatin;Chromatin Loop;chromatin remodeling;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Computing Methodologies;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Diagnosis;differential expression;Disease;Disease remission;Dissection;DNA;Downstream Enhancer;drug relapse;Drug resistance;Enhancers;Epigenetic Process;Event;Evolution;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Enhancer Element;genome-wide;Glioblastoma;Growth;Hi-C;Human;Hypermethylation;IGF1R gene;improved;In Vitro;in vivo;insight;Laboratories;Large-Scale Sequencing;leukemia;Malignant Neoplasms;Maps;Mediating;metaplastic cell transformation;Methods;MYC gene;Neighborhoods;new therapeutic target;NOTCH1 gene;novel;novel marker;novel strategies;Oncogene Activation;Oncogenes;Oncogenic;Outcome;Pathway interactions;Patients;pediatric acute leukemia;Pharmacotherapy;Point Mutation;Prognosis;promoter;Property;Recurrence;Regulation;Regulator Genes;Regulatory Element;Relapse;relapse patients;Resistance;Role;Sampling;Structure;T-Cell Development;targeted treatment;Techniques;Technology;Testing;therapy resistant;Thymus Gland;Time;tool;transcription factor;Transcriptional Regulation;Treatment outcome;treatment response;Tumor Suppressor Proteins;Untranslated RNA;Validation

PROJECT_TITLE: Dynamic 3D chromatin remodeling in acute leukemia - Resubmission - 1


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: This project examines the strategies that viruses use to promote the expression of their genes, which is fundamental for understanding pathogenic viruses. In addition, when viruses infect a human cell, they use the human cell’s machinery to promote their own gene expression. Therefore, by determining how viruses regulate their genes, the mechanisms of human gene regulation will simultaneously be discovered.

PI_NAMEs: CONRAD, NICHOLAS K (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Binding;Binding Proteins;Biochemical;candidate identification;Cells;Complex;Data;Ensure;exosome;Funding;Gene Expression;Gene Expression Regulation;Genes;Goals;helicase;Herpesviridae;Human;Human Herpesvirus 8;human pathogen;Immunocompromised Host;Infection;Integration Host Factors;Kaposi Sarcoma;Late Gene Transcriptions;Link;Lymphoproliferative Disorders;Lytic Phase;Masks;Mediating;Messenger RNA;Modeling;Molecular;Molecular Biology;mRNA capping;mRNA Decay;mRNA Export;novel;Nuclear;Nuclear Decay;Nuclear RNA;Oncogenic Viruses;pathogenic virus;Pathway interactions;Phase;Phosphodiesterase I;Play;Post-Transcriptional Regulation;premature;protein complex;Proteins;Quality Control;recruit;Regulation;Reporting;Resistance;RNA;RNA Binding;RNA Decay;RNA Stability;RNA-Binding Proteins;Role;Testing;tool;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Viral;Viral Gene Expression Regulation;Viral Genes;viral RNA;Virus;virus testing;Work

PROJECT_TITLE: Mechanisms of KSHV posttranscriptional gene regulation

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Palliative Care;Patient Safety

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: This research is relevant to public health as more than 1 in 5 Americans die in intensive care units (ICUs), and the majority of patients are older adults with advanced illness. This proposal will generate information to reduce distress among older ICU patients on mechanical ventilation who are transitioning to comfort focused care, and an intervention with the ICU team of nurses, doctors and therapists to improve symptom control. First, to better understand the patient experience and providers’ perspectives, ICU patients over 60 years old will be followed prospectively during the process of removing ventilator support; Second, a checklist intervention for the ICU team will be developed to improve the process of removing ventilator support; Finally, a pilot study will determine if the intervention is feasible to conduct and provide information for future studies to gauge efficacy in reducing episodes of distress.

PI_NAMEs: FEHNEL, COREY R (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Absence of pain sensation;Adherence;Adopted;advanced disease;Age;Agitation;airway obstruction;American;Area;Beds;Boston;Caring;Cessation of life;comorbidity;Consultations;Critical Care;Critical Illness;Data;Data Collection;Delirium;design;Development;Discipline of Nursing;Distress;Dose;Dyspnea;evidence base;Excision;experience;Expert Opinion;Family;field study;Frequencies;Future;Geriatrics;Guidelines;Hospitals;improved;Intensive Care Units;Intervention;Intervention Studies;Interview;Investigation;Israel;Literature;Measures;Mechanical ventilation;Medical;Multivariate Analysis;novel;Nurses;Observational Study;older adult;older patient;Older Population;Operative Surgical Procedures;pain scale;palliative;Palliative Care;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;pilot test;primary outcome;Principal Investigator;Process;process improvement;prospective;Prospective Studies;Protocol Compliance;Protocols documentation;Provider;Proxy;Public Health;Publishing;quality of death;Reaction;recruit;Research;Research Personnel;Resources;respiratory;Retrospective cohort study;Risk;Sample Size;Sedation procedure;skills;Standardization;Structure;surgery outcome;symptomatic improvement;Symptoms;Team Nursing;Testing;Time;Training;trend;Ventilator;Vulnerable Populations;Withdrawal;Woman;Work

PROJECT_TITLE: Intensive Palliative Care: Improving the Process of Palliative Ventilator Withdrawal Among Critically Ill Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This project aims to unravel the mechanisms underlying pathology and disease progression in early CAA. If BP, a modifiable risk factor, is confirmed to be associated with bleeding events and/or tau deposition, it is conceivable that targeted BP therapy could change disease course in early CAA. Such a low-cost feasible intervention could have tremendous benefit for the large numbers of individuals with early or even asymptomatic disease by reducing their risk for the CAA-related outcomes of hemorrhagic stroke and dementia.

PI_NAMEs: VISWANATHAN, ANAND  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta deposition;Affect;age related;Alzheimer's disease pathology;Ambulatory Blood Pressure Monitoring;Amyloid;amyloid imaging;amyloid pathology;Arteries;Biological;Biological Markers;Blood Pressure;blood pressure elevation;blood pressure variability;Blood Vessels;Brain hemorrhage;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Cerebrum;Clinical;Collaborations;Communities;cost;Data;Dementia;Deposition;Development;Disease;Disease Progression;Elderly;epidemiology study;Event;Exhibits;Funding;Hemorrhage;Impaired cognition;Individual;Intervention;Leptomeninges;Lesion;Link;Lobar;Magnetic Resonance Imaging;Measures;Methods;Microvascular Dysfunction;modifiable risk;Neurofibrillary Tangles;neuropathology;non-demented;Outcome;Pathologic;Pathology;Patients;Population;Positron-Emission Tomography;pre-clinical;prevent;Prospective cohort;Recording of previous events;Recurrence;Risk;Risk Factors;Role;Scanning;secondary analysis;Senile Plaques;Siderosis;Specificity;Stroke;tau aggregation;tau Proteins;Testing;vascular cognitive impairment and dementia;Vascular Diseases

PROJECT_TITLE: Vascular Pathology in Early and Asymptomatic Cerebral Amyloid Angiopathy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SHENYANG

ORG_COUNTRY: CHINA

ORG_FIPS: CH

ORG_NAME: CHINA MEDICAL UNIVERSITY

PHR: Project Narrative Development of transmission-blocking vaccines against the human malaria parasite Plasmodium vivax is urgently needed for malaria elimination. This project seeks to use a comprehensive antigen discovery pathway, including antigen identification through genome-wide immunological screening, validation in rodent malaria model, and further evaluation in P. vivax, to identify new transmission-blocking vaccine candidates for vivax malaria.

PI_NAMEs: CAO, YAMING  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Animals;Antibodies;Antibody Response;Antigen Targeting;Antigens;Asian;Avidity;B-Lymphocyte Epitopes;Biological Assay;Biology;Blood;Cell-Free System;Cells;Chimera organism;Clinical;Combined Vaccines;Complex;Culicidae;Data;design;Development;Epitopes;Evaluation;Face;feeding;Fertilization;fertilization antigen;Gene Expression Profile;genome-wide;Geography;Germ Cells;Goals;Human;Huntingtin-Associated protein 1;Immunologics;improved;in silico;Incidence;Infection;innovation;Interruption;Investments;Libraries;Life Cycle Stages;Malaria;malaria transmission;malaria transmission-blocking vaccine;Measures;Membrane;Midgut;Mining;Modeling;Morphology;Mus;nanoparticle;novel vaccines;Oocysts;Orthologous Gene;Parasites;Pathway interactions;Patients;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Plasmodium vivax;polyclonal antibody;Population Study;prevent;Protein Array;protein expression;Protein Microchips;Proteins;Proteome;Recording of previous events;Relapse;resilience;Rodent;screening;Sexual Development;Site;southeast Asian;ST13 gene;Symptoms;System;Technology;technology development;Testing;transcriptome;Transgenic Organisms;transmission process;transmission-blocking vaccine;trend;Vaccine Antigen;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;Vaccine Research;vaccine trial;vaccine-induced antibodies;Vaccines;Validation;vector mosquito;Virus-like particle;Vivax Malaria;Wheat;zygote

PROJECT_TITLE: Antigen discovery for transmission-blocking vaccines in Plasmodium vivax

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


NIH_SPENDING_CATS: Bioengineering;Neurodegenerative

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The relevance of the proposed studies to public health is that they will define mechanisms by which the Heat Shock Protein molecular chaperones and protein unfoldases function as cell stress responders that dissolve toxic protein aggregates and amyloids. These studies propose to use cryo-electron microscopy and biochemical/biophysical approaches to determine structural snapshots which identify how these proteins interact and mechanically unfold their substrates. The resulting information will provide insight into mechanisms that protect cells from deleterious protein misfolding and aggregation, events that underlie the cause of many neurodegenerative diseases including Alzheimer's and Parkinson's disease.

PI_NAMEs: SOUTHWORTH, DANIEL RYLAND (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acceleration;Address;alpha synuclein;Alzheimer's Disease;Amino Acids;Amyloid;amyloid formation;Architecture;ATP Hydrolysis;Binding;Biochemical;biological adaptation to stress;Biological Assay;biophysical techniques;Cell Aging;Cell Physiology;Cell Survival;Cellular Stress;Collaborations;Communication;Complex;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Crystallization;Cytoprotection;Disease;Event;Family;Filament;Fluorescence Resonance Energy Transfer;Future;genetic regulatory protein;Goals;grasp;Heat shock proteins;human disease;Hydrolysis;improved;insight;Life;Mass Spectrum Analysis;Mechanics;Mediating;member;Methods;Mitochondria;Modeling;Molecular Chaperones;Molecular Conformation;Motor;multicatalytic endopeptidase complex;mutant;Nature;Neurodegenerative Disorders;novel strategies;Parkinson Disease;Pathway interactions;Peptide Hydrolases;polypeptide;prevent;protein aggregation;protein misfolding;protein protein interaction;Proteins;Proteolysis;proteostasis;Public Health;Resolution;Rotation;Science;single-molecule FRET;Site;Specific qualifier value;Stress;Structure;Substrate Interaction;sup35;Surface;System;therapeutic target;unfoldase;Variant;Work;yeast prion;Yeasts

PROJECT_TITLE: Mechanisms of Protein Disaggregation and Turnover by AAA+ Chaperones

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The proposed study will examine the feasibility and initial efficacy of a stakeholder-informed, home-based, remotely supported and supervised exercise training program for wheelchair users with multiple sclerosis (MS). The proposed exercise training program was iteratively developed in partnership with community members using semi-structured interviews, a community advisory board, and focus group feedback wherein community members provided insights to develop and refine an exercise training program that suit the needs and preferences of wheelchair users with MS. Ultimately, the proposed study extends this line of research and may initiate a significant paradigm shift in rehabilitation research and practice by providing a critically needed home- based exercise training program for enhancing health, quality of life, participation, and independence of wheelchair user with MS.

PI_NAMEs: GEE, STEPHANIE SILVEIRA (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Adult;Adverse event;Aerobic Exercise;Attention;Behavior;behavior change;Behavioral;Body Composition;Central Nervous System;Cerebral Palsy;Cholesterol;Chronic;Clinical Trials;Communities;community advisory board;community engaged research;comorbidity;cost;Data;disability;Disabling condition;Disease;Disease Management;Disparity;Educational Intervention;Educational workshop;efficacy trial;Equipment;evidence base;evidence based guidelines;Exclusion;Exercise;exercise intervention;exercise prescription;exercise program;exercise training;experience;Fatigue;feasibility testing;Feedback;Fellowship;Focus Groups;formative assessment;Foundations;Functional disorder;Future;Glucose;Glycosylated hemoglobin A;Goals;gray matter;Guidelines;Health;Health Benefit;Health Promotion;Home;Immune;Immune System Diseases;improved;Individuals with physical disabilities;insight;Insurance;interest;Intervention;Interview;Mediating;Medical Care Costs;Medical center;meetings;member;Mental Depression;Metabolic;Mission;Multiple Sclerosis;multiple sclerosis patient;Nature;Needles;Neurodegenerative Disorders;novel;Occupational Therapy;Outcome;Pain;Participant;Pathway interactions;Perception;Personal Satisfaction;Pharmacological Treatment;Physical activity;Physical therapy;Population;preference;Prevention;Process;Productivity;programs;Protocols documentation;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;rehabilitation management;rehabilitation research;Rehabilitation therapy;Reporting;Research;Safety;Sample Size;Sampling;satisfaction;Spinal cord injury;strength training;Structure;Surveys;symptom management;symptomatic improvement;Symptoms;Testing;time use;Training Programs;Transportation;Triglycerides;United States;United States National Institutes of Health;Update;Wellness Program;Wheelchair user;Wheelchairs;White Matter Disease

PROJECT_TITLE: Feasibility and Initial Efficacy of a Wheelchair Exercise-Training Intervention for Persons with Multiple Sclerosis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE This application focuses on how cells turn production from each gene up or down in response to signals from their environments. The methods developed here will be applicable to understanding how cells process and act on information in organisms ranging from disease-causing fungi to humans. This may ultimately lead to better treatments for infectious diseases and chronic health conditions.

PI_NAMEs: BRENT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Benchmarking;Cell Physiology;Cells;Chronic;Collection;Computer software;Data;Data Set;Disease;DNA Binding;Engineering;Environment;Experimental Designs;Funding;fungus;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genome;Goals;Growth;Health;Human;infectious disease treatment;Lead;Maps;Metabolic;Methods;model organism;Modeling;Molecular;Nutrient;Organism;overexpression;pathogenic fungus;Personal Satisfaction;Pharmaceutical Preparations;Production;programs;Proteins;Reaction;Research;Resources;response;Saccharomyces cerevisiae;Sampling;Scientist;sensor;Signal Transduction;Stimulus;success;Systems Biology;Testing;transcription factor;transcriptome;Work;Yeasts

PROJECT_TITLE: Mapping and modeling transcription factor networks


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Biomolecular modeling and simulation is a key technology for leveraging the $14B global investment in biomolec- ular structure data in the protein databank to understand the basic molecular mechanisms underlying biology and disease and the development of new therapies. In this proposal, we aim to expand the development of OpenMM, a free and open source biomolecular modeling and simulation package that can exploit a wide range of consumer-grade and high-end graphics processing units (GPUs) to enable researchers and applications built on OpenMM to achieve high performance with extreme ﬂexibility. A key aspect of this proposal is to accelerate research in the emerging ﬁeld of biomolecular machine learning by tightly integrating OpenMM with modern ma- chine learning frameworks, enabling researchers to build, use, and deploy machine learning potentials, collective variables, and integrators to advance the state of biomolecular modeling.

PI_NAMEs: MARKLAND, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Academia;Acceleration;Architecture;Automobile Driving;Biological;Biological Process;Biological Response Modifier Therapy;Biology;Chemical Models;Chemicals;Chemistry;cluster computing;Code;Communities;Computer Vision Systems;Custom;Data;data modeling;Data Set;deep learning;deep neural network;Development;Disease;drug development;Ecosystem;Ensure;enzyme mechanism;Event;flexibility;Free Energy;Funding;Future;Goals;Home;Hybrids;Industry;insight;interoperability;Investigation;Investments;Laboratories;Libraries;Ligands;Machine Learning;machine learning framework;machine learning model;Methods;model development;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;molecular mechanics;next generation;novel therapeutics;open source;operation;Performance;physical model;Plug-in;predictive modeling;Productivity;protein data bank;Proteins;Pythons;quantum;repository;Research;Research Personnel;Running;Sampling;Science;simulation;small molecule;small molecule therapeutics;software infrastructure;Specific qualifier value;Speed;Standardization;Structure;Study models;Sustainable Development;System;Technology;TensorFlow;tool;training data;United States National Institutes of Health;Update;Work

PROJECT_TITLE: OpenMM: Scalable biomolecular modeling, simulation, and machine learning

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Narrative  A new T32 training program entitled “Program to enrich translation and multimodal research in Alzheimer’s disease and related dementias (PET & MR in ADRD)" will consist of 4 postdoctoral training slots to be filled by MD, PhD, and MD/PhD applicants. The training plan is rich in neuroimaging methodology and clinical applications research in AD and AD related dementias. The trainee pool will be from diverse backgrounds and strongly representative of women and underrepresented minority groups.

PI_NAMEs: PRICE, JULIE C (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's disease related dementia;multimodality;programs;Research;Translations

PROJECT_TITLE: Program to enrich translation and multimodal research in Alzheimers disease and related dementias

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: The proposed research will test the efficacy of conversation treatment for individuals with aphasia and explore whether the effects of treatment differ as a result of treatment size (large group or dyad), group composition (heterogenous versus homogenous profiles of aphasia) and/or the severity of the aphasia. The results will inform health care delivery models to optimize both treatment outcomes and utilization of financial and other resources. The results will also help develop and refine a hypothesized model about the mechanisms underlying conversation treatment.

PI_NAMEs: DEDE, GAYLE L;HOOVER, ELIZABETH L (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;Aftercare;American;Aphasia;Behavior;Behavioral;Caring;Clinical;Clinical Trials;Communication;Communication Barriers;Communication impairment;Control Groups;cost effective;Cues;Data;Dimensions;dosage;efficacy evaluation;efficacy testing;Enrollment;Ensure;Event;evidence base;Future;Goals;Health;Health Services Accessibility;Hobbies;Impairment;improved;Individual;Intervention;Knowledge;Language;Language Disorders;Lead;Learning;Life;Linguistics;Logic;Maps;Measurable;Measures;Medical Care Costs;member;Modeling;mortality;multimodality;Names;Outcome;Outcome Measure;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Performance;Persons;Phase;primary outcome;programs;Psychosocial Assessment and Care;Psychosocial Factor;Randomized;Randomized Controlled Clinical Trials;Research;Resources;Risk;Sampling;secondary outcome;Service delivery model;Severities;Site;skills;Social isolation;social relationships;Speech Pathologist;Standardization;Testing;treatment effect;Treatment Efficacy;treatment group;Treatment outcome;treatment research;Variant;Work

PROJECT_TITLE: Understanding the Mechanisms of Change and Optimal Parameters in Conversation Treatment for Aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]