ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative (Parent Grant Application) Advanced prostate cancer patients often fail androgen receptor-directed therapy and develop lethal castration- resistant disease, which constitutes a major challenge in clinical management, raising an urgent need to develop effective new therapeutic strategies to improve patient survival. The proposed studies define the functional and mechanistic roles of monoamine oxidase A, a recently identified therapeutic target in prostate cancer, which synergizes with androgen receptor to form a reciprocally interactive complex promoting prostate cancer growth and progression. Our studies will provide new fundamental knowledge of the molecular basis of androgen receptor regulation and the development of resistance to castration and next-generation antiandrogen drugs, thus laying the foundations for a new combination therapy with the potential for rapid translation to treat advanced prostate cancers.

PI_NAMEs: WU, BOYANG  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: abiraterone;Acetates;Address;advanced prostate cancer;American;Androgen Antagonists;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Response Element;androgen sensitive;Androgens;antagonist;Applications Grants;Biochemical;Biological Assay;cancer cell;Cancer Etiology;cancer initiation;Cancer Patient;cancer prevention;Cancer Relapse;Castration;Cessation of life;Chemicals;ChIP-seq;Clinical;Clinical Data;clinical investigation;Clinical Management;cohort;combat;Combined Modality Therapy;Complement;Complex;Coupled;CYP17A1 gene;Data Set;Dependence;Development;dietary;Disease;Disease Resistance;Drug resistance;E-Box Elements;effective therapy;efficacy evaluation;Enhancers;Environment;enzalutamide;Enzymes;Epigenetic Process;Evaluation;FDA approved;Foundations;Gene Expression;Gene set enrichment analysis;Genes;Genetic;Genetic Transcription;Genomics;Growth;Human;Hydrogen Peroxide;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;insight;Journals;knock-down;Knowledge;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;men;Mitochondria;Molecular;Molecular Profiling;Molecular Target;molecular targeted therapies;monoamine;Monoamine Oxidase A;mRNA Expression;Nature;Neoplasm Metastasis;New Agents;new combination therapies;next generation;NKX3-1 gene;novel;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;parent grant;Patients;Pharmaceutical Preparations;pharmacologic;promoter;prostate cancer cell;prostate cancer cell line;prostate cancer progression;Prostate Cancer therapy;protein expression;Reactive Oxygen Species;Receptor Signaling;Regulation;Relapse;Reporting;Resistance;Resistance development;response;Role;Sampling;Signal Transduction;small hairpin RNA;Surveys;synergism;System;targeted treatment;Testing;Tetracyclines;therapeutic candidate;therapeutic target;TMPRSS2 gene;Transactivation;transcription factor;transcriptome sequencing;Translations;Treatment Protocols;treatment strategy;tumor;tumor growth;tumor progression;Xenograft Model

PROJECT_TITLE: MAOA and AR Reciprocal Crosstalk in Prostate Cancer


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The number of new HIV infections in Sub-Saharan Africa remain well above global elimination targets. The study aims to accelerate the path to HIV elimination with new innovative combination strategies for HIV prevention and treatment that are effective, efficient, scalable and reduce preventable infections and deaths.

PI_NAMEs: HAVLIR, DIANE V (contact);KAMYA, MOSES ROBERT;PETERSEN, MAYA LIV

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: Acceleration;Address;Adoption;Africa;Africa South of the Sahara;AIDS prevention;Alcoholic beverage heavy drinker;antenatal care;antiretroviral therapy;care systems;Cessation of life;Clinic;Communities;community barrier;Community Health;Consultations;cost;cost estimate;Country;Data;design;disability-adjusted life years;Disease;Economics;effectiveness measure;effectiveness outcome;efficacy outcomes;Epidemic;Evaluation;Family Planning;flexibility;Gender;Health;Heavy Drinking;high risk population;HIV;HIV Infections;Hypertension;implementation evaluation;implementation outcomes;Incidence;Individual;Infection;infection rate;innovation;Intervention;Investments;Knowledge;Life;mathematical model;Mediation;men;Methods;Modality;Modeling;mortality;multi-component intervention;Outcome;Pathway interactions;Persons;Phase;Policies;Policy Maker;Population;pre-exposure prophylaxis;Prevention;Prevention strategy;Process;Prophylactic treatment;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Services;Site;skills;Social Behavior;standard of care;stressor;Structure;Subgroup;System;Testing;therapy design;transmission process;treatment choice;treatment strategy;uptake;Viral;Viral Load result;Vocational Education;young woman;Youth

PROJECT_TITLE: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Osteoarthritis;Physical Rehabilitation;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The results of this research will yield an improved understanding of how a common condition termed “femoroacetabular impingement syndrome” alters the shape and biomechanics of the hip. These data should inform the development of new methods to diagnose and treat this disease.

PI_NAMEs: ANDERSON, ANDREW EDWARD (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 12 year old;aged;Anatomy;Animal Model;Arthrography;Articular Range of Motion;Articulation;Biomechanics;bone;Cartilage;Clinical;cohort;Computational Technique;Control Groups;coping;Data;Deformity;Degenerative polyarthritis;design;Development;Diagnosis;Disease;Elements;Etiology;Evaluation;Exclusion;Exhibits;experience;Femur;femur head;Film;Finite Element Analysis;Fluoroscopy;Functional disorder;gait rehabilitation;Growth;High Prevalence;Hip Joint;Hip Osteoarthritis;Hip region structure;Image;improved;in silico;in vivo;Individual;Injury;innovation;insight;Intuition;Joints;kinematics;Left;Life;Location;Magnetic Resonance;Maps;Measurement;Measures;Mechanics;Methods;Modeling;Morphology;Motion;Neck;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;osteochondral tissue;Outcome;Pain;pain relief;Pathogenesis;Pathologic;pathomechanics;Patients;Population;Positioning Attribute;Procedures;radiological imaging;Replacement Arthroplasty;Reporting;Research;Resource Sharing;Scanning;Second Look Surgery;Shapes;shear stress;Stress;success;Symptoms;Syndrome;Techniques;Technology;theories;Traction;Translations;Visual;Visualization;Walking;young adult

PROJECT_TITLE: Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: This bench-to-bedside pilot study evaluates the safety of a novel medical technology, LANT (Laser-Activated NanoTherapy), for treating a type of skin cancer called cutaneous squamous cell carcinoma (cSCC). Veterans have a high risk for this type of skin cancer due to extensive exposures during the line of duty to the sun and chemical warfare agents like Agent Blue and Lewisite. This project is of significant interest because Veterans with difficult-to-treat cancer facing poor clinical outcomes could greatly benefit from LANT. This new cancer treatment may address the unmet need for a local and minimally invasive alternative to radiation when surgery is not a viable option.

PI_NAMEs: GREEN, HADIYAH-NICOLE  (contact)

PROJECT_TERMS: 3D ultrasound;Address;Age;Appearance;Area;Arsenic;bench to bedside;Biodistribution;Biological;Biopsy;Burn injury;cancer therapy;Cell Death;Cell Death Induction;Cell Therapy;Cessation of life;Chemical Warfare Agents;Cicatrix;Clinical;comorbidity;Connective Tissue;Control Groups;Data;Dermis;design;Diagnosis;digital;Domestic Pig;Dose;effective therapy;Effectiveness;Ensure;Epidermis;Evaluation;Excision;first-in-human;Generations;Hematology;high risk;Histologic;Histology;Histopathology;Human;Image;immunosuppressed;In Vitro;in vivo;Individual;Inductively Coupled Plasma Mass Spectrometry;Infection;Injections;Injury;innovation;insight;Institutional Review Boards;interest;Lasers;lewisite;Local anesthesia;Malignant Neoplasms;Measures;Medical Technology;melanocyte;Melanoma;Methods;micrography;minimally invasive;Modeling;Mohs Surgery;Morphology;mouse model;Mus;nanoGold;nanoparticle;nanorod;nanotherapy;Neoplasm Metastasis;new technology;novel;Operative Surgical Procedures;Outcome;Output;Pain;pharmacokinetics and pharmacodynamics;Photography;Pilot Projects;porcine model;Process;Prognosis;Publications;Publishing;Radiation;recruit;Recurrence;Research Design;Risk;Safety;safety assessment;Serology;side effect;Site;Skin;Skin Cancer;skin healing;skin squamous cell carcinoma;Squamous cell carcinoma;standard of care;subcutaneous;Subcutaneous Tissue;Surface;Technology;Testing;the sun;therapeutically effective;therapy outcome;Thermal Ablation Therapy;Thermography;Time;Tissues;Toxic effect;Translating;tumor;Ulcer;Ultrasonography;Ultraviolet Rays;United States;Veterans;Work;Xenograft procedure

PROJECT_TITLE: Safety Assessment of Laser Activated NanoTherapy (LANT) as a Potential Treatment for Veterans with Cutaneous Squamous Cell Carcinomas


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: There is a 20% chance of a decrease in left ventricular function after surgical correction of primary mitral regurgitation (PMR). This grant will utilize cardiac magnetic resonance imaging and acute cardiac and kidney injury during cardiopulmonary bypass to predict a fall in left ventricular function after surgery to correct PMR.

PI_NAMEs: DELL'ITALIA, LOUIS J. (contact)

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Antibodies;Aorta;Attenuated;Binding;Biological Models;Blood;Brain natriuretic peptide;Cancer Patient;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiac Volume;Cardiopulmonary Bypass;cell injury;Cells;Circulation;Closure by clamp;Creatinine;Cytoskeleton;Dimensions;EFRAC;Erythrocytes;exosome;falls;Ferritin;Fibronectins;Functional disorder;Geometry;Grant;Guidelines;Haptoglobins;Heart;heart damage;Heart Injuries;Heme;Hemoglobin;Hemolysis;Hemopexin;Image;improved;in vivo;in vivo Model;indexing;individual response;Inflammatory Response;Injections;Injury;Injury to Kidney;Ischemia;Kidney;Knowledge;LCN2 gene;Left Ventricular Ejection Fraction;Left Ventricular Function;Left Ventricular Remodeling;Link;machine learning method;machine learning model;Magnetic Resonance;Mediating;Methods;Mitochondria;Mitral Valve;Mitral Valve Insufficiency;Myocardial;Myocardium;novel;novel strategies;Operative Surgical Procedures;Oxidative Stress;Pathogenicity;Patients;Performance;predictive modeling;Proteins;Rattus;renal damage;repaired;Reperfusion Injury;Risk;Series;Severities;Slice;Staging;Stress;surgical risk;System;Testing;Thinness;treatment strategy;Troponin;uptake;urinary;Urine

PROJECT_TITLE: Exosome Mediated Effects on Cardiac Injury during Cardiopulmonary Bypass


ORG_CITY: DALLAS

ORG_NAME: VA NORTH TEXAS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Project Narrative Esophageal cancer disproportionately affects US veterans and is associated with considerable morbidity and mortality. If repurposing the antifungal drug itraconazole to treat esophageal cancer successfully improves pathologic complete response rates in patients with surgically resectable disease, this should increase overall survival rates. Identifying which patients will respond to chemoradiation and itraconazole by developing novel biomarkers would maximize the impact of this intervention.

PI_NAMEs: WANG, DAVID H (contact)

PROJECT_TERMS: Adverse event;Affect;AKT inhibition;angiogenesis;Angiogenesis Inhibition;anti-fungal agents;Antineoplastic Agents;arm;Biopsy;Blood;cancer cell;Cell Cycle Arrest;Cell Proliferation;chemoradiation;Clinical Trials;comparison control;Data;density;Disease;ERBB2 gene;Erinaceidae;esophageal cancer patient;Esophageal Neoplasms;Esophageal Tissue;Esophagectomy;Esophagus;exome sequencing;Exposure to;G1/S Transition;General Population;genomic biomarker;genomic predictors;genomic profiles;Genomics;Germ Lines;Goals;Growth;HER2 inhibition;improved;In complete remission;Incidence;Institution;Intervention;Itraconazole;KDR gene;Malignant neoplasm of esophagus;Measurement;Measures;Mediating;metastatic esophageal;Molecular;Monitor;Morbidity - disease rate;mortality;Neoadjuvant Therapy;neoplastic cell;NOD/SCID mouse;novel marker;novel therapeutics;Oncogenic;Operative Surgical Procedures;Oral;Outcome;partial response;Pathologic;Pathology;Pathway interactions;patient response;Patients;peripheral blood;Pharmaceutical Preparations;Phase;Phase 0 Trial;phase II trial;PIK3CG gene;Placebos;Plasma;Population;precision medicine;Prediction of Response to Therapy;Predisposition;primary endpoint;Prognosis;prognostic;Proto-Oncogene Proteins c-akt;radiation resistance;Recurrence;Resectable;Residual Neoplasm;Resistance;response;Role;Safety;Schedule;secondary endpoint;Signal Pathway;Signal Transduction;smoothened signaling pathway;standard of care;Survival Rate;Testing;Time;treatment effect;treatment response;trial design;tumor;tumor DNA;tumor growth;Veterans;Xenograft procedure

PROJECT_TITLE: A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Human Genome;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Los Angeles

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Somatic cell genetic heterogeneity within an individual arises over the course of the human lifespan; but the quantitative extent and qualitative nature of this cell-to-cell change continues to be a matter of conjecture, because methods are limited. We recently developed a method to use single colon crypts as representative of one stem cell that would allow determination of the extent to which cells of the body diverge from each other genetically over the human lifespan. As analysis of the human body for medical and therapeutic reasons relies upon progressively fewer somatic cells, this knowledge of somatic cell genetic heterogeneity will become increasingly important.

PI_NAMEs: HSIEH, CHIH-LIN  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;Affect;Age;age group;age related;age related changes;Aging;Animals;Autoimmune Diseases;base;Biochemical;Bioinformatics;cancer risk;Cells;Child;Colon;colonic crypt;Computer software;Congestive Heart Failure;Data;Degenerative Disorder;Diagnostic;Diet;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence;Elderly;Environment;Excision;Foundations;Future;Gene Conversion;Genes;genetic analysis;Genetic Heterogeneity;Genetic Polymorphism;Genome;genome analysis;genome sequencing;Genomic Segment;Genomics;Germ Lines;Health;Heterogeneity;high risk;Human;Human body;human subject;In Vitro;Incidence;Individual;individual patient;Inflammatory;insertion/deletion mutation;insight;joint destruction;Knowledge;Lead;Libraries;life span;Life Style;Macular degeneration;Malignant Neoplasms;Medical;Methods;mitochondrial genome;Molecular;Monitor;Morphologic artifacts;Muscle Weakness;Mutation;Mutation Analysis;Nature;Normal tissue morphology;Nuclear;Nucleotides;Organism;Pathway interactions;Patients;Point Mutation;precision medicine;Preventive measure;Probability;Publishing;repaired;Replication Error;Risk Factors;Sampling;sarcopenia;Site;skeletal;Somatic Cell;Somatic Cell Genetics;Somatic Mutation;Source;stem cells;Testing;Therapeutic;Time;Tissue Sample;Tissues;validation studies;Variant;whole genome;Work

PROJECT_TITLE: GENETIC HETEROGENEITY AMONG HUMAN SOMATIC CELLS AND ITS ACCUMULATION WITH AGE

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: RELEVANCE (See instructions): Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity by presenting antigens to cytotoxic T cells and are directly associated with immune-mediated tumor rejection and the success of immunotherapy. A better understanding of the immune pathways regulating cDC1 metabolism and function may lead to new therapeutic strategies to boost antitumor immunity and increase the responsiveness of cancer patients to immunotherapies such as checkpoint blockade.

PI_NAMEs: CHI, HONGBO  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Algorithms;Amino Acids;anti-tumor immune response;Antigen Presentation;Award;Biochemistry;Biological Assay;Biological Process;Biology;Cancer Model;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular biology;Cellular Metabolic Process;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR library;CRISPR screen;Custom;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Disease;experience;Foundations;FRAP1 gene;functional genomics;Funding;Genes;Genetic;genetic approach;Genetic Screening;Genomic approach;Goals;Heterogeneity;high dimensionality;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologics;Immunology;Immunotherapy;in vivo;in vivo Model;Inflammation;Instruction;intercellular communication;Intercellular Fluid;Laboratory Study;Libraries;Link;Lipids;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;multidisciplinary;Nature;neoplastic cell;novel;novel therapeutic intervention;Nutrient;OPA1 gene;Paper;pathogen;Pathway Analysis;Pathway interactions;Phenotype;Positioning Attribute;Process;programs;Publications;rapid growth;Regulation;Research;response;Role;screening;Shapes;Signal Transduction;single-cell RNA sequencing;STK11 gene;success;System;Systems Biology;T cell response;T-Lymphocyte;therapeutic target;Tissues;transcriptomics;translational approach;tumor;Tumor Immunity;tumor microenvironment;tumor progression

PROJECT_TITLE: Metabolic checkpoint in dendritic cell subsets and adaptive immunity


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Physical Activity;Prevention;Rehabilitation;Telehealth;Uterine Cancer;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE THE PARENT GRANT APPLICATION Despite the documented importance of physical activity for cancer survivorship, a large proportion of breast and endometrial cancer survivors remain physically inactive. In contrast to the “one size fits all” approach used by most previous physical activity interventions for cancer survivors, this trial will test an adaptive intervention approach that reserves the most resources and support for women who do not fare well with a lower-cost, minimal intervention. The results from this trial will inform the development of scalable physical activity interventions for breast and endometrial cancer survivors.

PI_NAMEs: PHILLIPS, SIOBHAN MARIE (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;Accountability;adaptive intervention;Address;American Cancer Society;Applications Grants;behavior change;Breast;burden of illness;cancer care;Cancer Prognosis;cancer recurrence;Cancer Survivor;Cancer Survivorship;Caring;Characteristics;Chronic Disease;Classification;Clinic;Clinic Visits;Communication;cost;Data;design;Development;Disease;Disease Outcome;disorder risk;Dose;Electronic Health Record;Electronic Mail;Endometrial Carcinoma;Ensure;Evaluation;Exercise;exercise intervention;Failure;Fatigue;Feedback;fitbit;follow-up;functional status;Goals;Health;Human;improved;Individual;innovation;Intervention;intervention effect;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;mHealth;Morbidity - disease rate;mortality;novel;parent grant;Participant;patient health information;patient portal;Patients;Performance;personalized approach;Persons;Physical activity;physical inactivity;Population;primary outcome;programs;Quality of life;Randomized;Recommendation;Resource Allocation;Resources;responders and non-responders;response;Self Efficacy;Sequential Multiple Assignment Randomized Trial;Site;smartphone application;standard care;success;Survivors;survivorship;Symptom Burden;symptomatic improvement;Symptoms;Technology;telephone coaching;Testing;Text Messaging;Time;tool;Translating;translational barrier;Transportation;Treatment Side Effects;vigorous intensity;Visit;wearable device;Woman

PROJECT_TITLE: Multi-site adaptive trial of a technology-based, EHR-integrated physical activity intervention in breast and endometrial cancer survivors


ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Contact PD/PI: Vilgelm, Anna E Project Narrative The focus of this project is on pre-clinical development of a novel therapeutic concept where melanoma tumor growth is controlled by directly targeting tumor cells and by making them easier targets for the anti-tumor immune response. This research will improve our understanding of tumor-host interactions, and enable effective therapeutic modulation of these interactions. This work should to have a profound impact on the survival of metastatic melanoma patients by advancing a novel therapy for patients who fail to respond to standard of care treatments. Page 7 Project Narrative

PI_NAMEs: VILGELM, ANNA E (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;anti-PD-L1;anti-tumor immune response;Anti-viral Response;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;aurora kinase;BCL2 gene;Binding;biological adaptation to stress;Biometry;Cell Aging;Cell Cycle Arrest;cell growth;Cell Survival;Cells;checkpoint therapy;chemokine;Chemoresistance;Chemotherapy and/or radiation;Clinic;clinical development;clinical predictors;Combined Modality Therapy;cytokine;Cytostatics;Data;Development;Disease remission;DNA;Dose;Drug Combinations;effector T cell;efficacy evaluation;experimental study;Failure;Flow Cytometry;Galactose Binding Lectin;Genomics;Goals;host neoplasm interaction;Immune;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunodeficiency;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunologic Stimulation;Immunologics;improved;improved outcome;Inflammatory;inhibitor;Injectable;innate immune mechanisms;innate immune sensing;Innate Immune System;interest;kinase inhibitor;Lesion;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Micrometastasis;Microtubules;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;optimal treatments;overexpression;Paclitaxel;Pathology;Pathway interactions;Patients;PDL1 inhibitors;Pharmaceutical Preparations;Phase;pre-clinical;preclinical development;preclinical study;preclinical trial;predicting response;predictive marker;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;Property;Protein Array;Proteomics;receptor;Receptor Signaling;recruit;Relapse;Reporter;Reporting;Research;Resistance;response;RNA;Role;Schedule;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;standard of care;STING agonists;T cell infiltration;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;therapeutically effective;therapy outcome;Time;transcription factor;transcriptomics;Treatment Protocols;tumor;Tumor Antigens;Tumor Burden;tumor growth;tumor immunology;Tumor Promotion;Up-Regulation;Work

PROJECT_TITLE: Combining senescence-inducing and senolytic agents to improve melanoma therapy


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Development of PD-1 and PD-L1 inhibitors is a major breakthrough in cancer immunotherapy, yet clinical success is restricted to a small subset of cancer patients. Our proposed studies aim to uncover a novel regulatory mechanism of the PD-L1/PD-1 pathway and to elucidate the mechanisms of action of their therapeutic inhibitors, using novel, unique and precise assays. Execution of the proposed research will lay the foundation for designed more effective and durable PD-1 targeted cancer immunotherapy.

PI_NAMEs: HUI, ENFU  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affect;anti-PD1 antibodies;Antibodies;Antigen-Presenting Cells;Applications Grants;Binding;Biochemical;Biological Assay;Biological Markers;Blocking Antibodies;cancer immunotherapy;Cancer Patient;CD28 gene;Cell Culture Techniques;Cell Surface Proteins;Cells;Clinical;Coculture Techniques;cytotoxicity;design;Development;Dimensions;experimental study;extracellular;FDA approved;Foundations;Goals;Human;Hybrids;Immune;immune checkpoint;immune checkpoint blockade;Immunotherapy;improved;Infiltration;inhibitor therapy;innovation;insight;Ligands;live cell imaging;liver cancer model;Malignant Neoplasms;Measures;Mediating;membrane reconstitution;Modeling;Molecular;Mus;neoplastic cell;novel;Outcome;Pathway interactions;patient population;patient subsets;Patients;PD-1 blockade;PD-1 pathway;PD-1/PD-L1;PD-L1 blockade;PDL1 inhibitors;Phosphoric Monoester Hydrolases;prevent;programmed cell death ligand 1;programmed cell death protein 1;receptor;reconstitution;Regulation;Reporting;Repression;Research;response;Science;Signal Transduction;success;System;T cell response;T-Lymphocyte;targeted treatment;Testing;Therapeutic antibodies;Treatment Efficacy;treatment response;tumor;Tumor Antigens;Tumor Escape;tumor growth;Tumor Immunity;Work

PROJECT_TITLE: Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT SUMMARY N/A Project Narrative

PI_NAMEs: CHEN, CHUN-WEI DAVID (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acetylation;Achievement;Acute leukemia;Binding;Biochemical;Biotin;cancer type;Cell Line;Chimeric Proteins;ChIP-seq;Chromatin;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;density;efficacy evaluation;Elements;Epigenetic Process;Exhibits;functional genomics;Gene Cluster;Gene Expression;Gene Expression Regulation;Gene Rearrangement;Genes;genetic approach;Genetic Transcription;genome-wide;Histone Acetylation;histone acetyltransferase;Histone Deacetylation;Histone H3;histone modification;Histones;Human;improved;In Vitro;in vivo;innovation;Left;leukemia;leukemogenesis;Libraries;Lysine;Malignant Neoplasms;Mediating;MEIS1 gene;Methylation;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;Molecular;Mutagenesis;mutant;novel;novel therapeutic intervention;Oncogenes;patient derived xenograft model;Patients;Peptides;pharmacologic;Phase I Clinical Trials;PHD Finger;pre-clinical;programs;Proteins;Publishing;Reader;recruit;Regimen;Research;Role;Scanning;SIRT1 gene;small hairpin RNA;Survival Rate;targeted treatment;Techniques;Technology;Tertiary Protein Structure;Therapeutic;Transcriptional Activation;treatment response;Validation;Work;World Health Organization

PROJECT_TITLE: Combinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage Leukemia


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Women Veterans are a fast growing population in VA and one that has healthcare needs distinct from the rest of the predominantly male population. In order to provide high-quality care for women, the VA has developed a specific program for women’s healthcare which includes designated women’s health providers and separate clinic structures for women. While the quality of women’s health care in VA has improved significantly in the last few decades, barriers to optimal care exist. Specifically, women Veterans face obstacles to receiving health care due to disproportionate caregiver responsibilities, work-life balance issues, and exposure to discrimination such as stranger harassment on VA grounds. Providing women Veterans the opportunity to use virtual care for the right health care concerns at the right time could create new ways for women to access timely needed care. This project seeks to create a package of approaches to improving when and how virtual care is offered to women Veterans.

PI_NAMEs: GIERISCH, JENNIFER MARIE;GOLDSTEIN, KAREN M. (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Age;Area;black women;burden of chronic illness;care delivery;care providers;career life balance;Caregivers;Caring;Client satisfaction;Clinic;Clinical;Communication;Communities;Comprehensive Health Care;Congresses;connected care;COVID-19 pandemic;Data;Data Collection;design;digital platform;Discrimination;Effectiveness;Emergency Situation;equity, diversity, and inclusion;ethnic diversity;Evaluation;evidence base;experience;Exposure to;Face;field study;Goals;harassment;Health;health care delivery;Health care facility;health care service;health disparity;health equity;Health Personnel;Healthcare;Household Heads;implementation outcomes;implementation strategy;improved;Infrastructure;innovation;Interview;Literature;male;Maps;marginalization;men;Menopause;Methodology;Methods;military veteran;Modality;Modeling;novel;online resource;operation;Outcome;pandemic disease;Patient Care;patient engagement;patient oriented;Patient-Centered Care;patient-clinician communication;Patients;Peer Review;Persons;Population;Positioning Attribute;post-COVID-19;post-pandemic;practice-based research network;pre-pandemic;Preventive;primary care team;Procedures;programs;Provider;Quality of Care;racial diversity;Reporting;Reproductive Health;Research;Resistance;Resources;Rest;Review Literature;Rural;Rural Health;satisfaction;Science;Services;Source;Structure;telehealth;Telephone;Time;Translating;Uncertainty;Veterans;virtual;virtual delivery;virtual healthcare;Woman;Women's Health;Women's Health Services;women's outcomes;Women's Rights;Work

PROJECT_TITLE: CompreHEnsive ViRtual Care for WOmen VEteranS (HEROES)

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HADLEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE (RELEVANCE) The A1 domain of blood clotting protein von Willebrand factor mediates platelet adhesion to sites of vascular damage. The proposed project aims to understand how the autoinhibitory module, a structural and functional component at the flanking regions of A1, regulates A1 activation during bleeding. Elucidating this mechanism will help us understand how von Willebrand disease, the most common hereditary bleeding disorder affecting 1% of the population, is developed, as well as provide significant implications for treating bleeding and thrombotic disorders.

PI_NAMEs: ZHANG, XIAOHUI  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adhesions;Affect;Amino Acids;Area;Binding;Binding Proteins;Biological Assay;Biomechanics;Biophysical Process;biophysical techniques;biophysical tools;Blood Circulation;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;C-terminal;Cardiovascular Diseases;Coagulation Process;Collagen;Complex;Defect;design;Detection;disulfide bond;experimental study;FDA approved;Fluorescence;Fluorescence Microscopy;gain of function mutation;Glycoprotein Ib;glycoprotein receptor GPIb-IX;glycosylation;Hematological Disease;Hemorrhage;Human;Human body;Inherited;Investigation;Lead;Link;Location;mechanical properties;Mechanics;Mediating;Modeling;models and simulation;Molecular;molecular dynamics;molecular modeling;Mutate;Mutation;N-terminal;nanobodies;Nature;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Pharmaceutical Preparations;Plasma Proteins;Platelet aggregation;Platelet Glycoproteins;Play;Polysaccharides;Population;preempt;prevent;Prevention;Prevention strategy;Property;Protein Biochemistry;Protein Chemistry;Proteins;Reaction;Reagent;receptor;Regulation;Reporting;Role;Series;Serine;Sialic Acids;single molecule;Site;Spectrum Analysis;Structure;success;Testing;Therapeutic;Threonine;Thrombosis;Thrombotic Thrombocytopenic Purpura;Variant;von Willebrand Disease;von Willebrand Factor

PROJECT_TITLE: Mechanical regulation of von Willebrand factor

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Inflammatory bone loss can be induced by excessive activation of bone-resorbing osteoclasts. Osteoclast activation is significantly affected by multiple membrane receptors and their intracellular signaling pathways. Understanding the molecular pathways that control osteoclast maturation and activation is required in order to properly treat inflammatory bone pathologies.

PI_NAMEs: CHOI, YONGWON  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Actins;Address;Adhesions;Affect;Antibodies;Biological Assay;Biological Markers;Biological Process;Biology;bisphosphonate;bone;bone loss;Bone Marrow;Bone Marrow Cells;Bone Resorption;bone strength;Cadherins;Calcium;CD 200;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;Cell Maturation;Cells;Chemicals;Chimera organism;Coupled;Cytoplasmic Tail;Data;Disease;Dyes;Exhibits;Extracellular Domain;Fibronectins;Genes;Hematopoietic;Homeostasis;Immune response;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Response;inhibitor;Integrins;interest;knock-down;Label;Ligature;lipophilicity;Measures;Mediating;Mediator;member;Membrane;Mesenchymal;microCT;Modeling;Molecular;molecular marker;Mononuclear;Motility;Mus;Oncoproteins;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Pathologic;Pathology;Pathway interactions;Patients;Periodontitis;Phosphoric Monoester Hydrolases;Physiological;Physiological Processes;Protein Family;Protein Isoforms;Protein phosphatase;Proteins;Publishing;receptor;Regulation;rho GTP-Binding Proteins;Role;screening;Screening Result;side effect;Signal Pathway;Signal Transduction;Slice;Small Interfering RNA;Stains;Stimulus;Testing;therapeutic target;TNFSF11 gene;Tracer;trafficking;Vesicle;Work

PROJECT_TITLE: Protocadherin 7 and Osteoclast Maturation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The number of HIV-1-infected patients who use opioid drugs is increasing, but residual viral reservoirs in these patients have never been systematically studied. In this project, we will use novel next-generation sequencing approaches for characterizing the chromosomal position and chromatin structure of intact proviruses in a cohort of HIV-1-infected opioid drug users.

PI_NAMEs: LICHTERFELD, MATHIAS ;YU, XU  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: adaptive immune response;Address;Adherence;Affect;Anti-Retroviral Agents;antiretroviral therapy;ATAC-seq;Binding;bisulfite sequencing;Buprenorphine;CD4 Positive T Lymphocytes;Cells;Characteristics;Chromatin;chromatin immunoprecipitation;chromatin modification;Chromatin Structure;chromosomal location;Clinical;cohort;Combined Modality Therapy;Data;Disease;Disease remission;DNA;DNA Methylation;Drug abuse;drug addict;Drug user;Epigenetic Process;Exclusion;Fentanyl;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Health Services Accessibility;Heroin;high risk;histone modification;HIV;HIV Genome;HIV-1;Hydromorphone;Immune response;Improve Access;Incidence;Individual;Infection;injection drug use;Innate Immune Response;integration site;Intervention;Investigation;Knowledge;Length;Ligation;Maps;Mediating;Methadone;Modification;Molecular;Molecular Profiling;Molecular Structure;Newly Diagnosed;next generation sequencing;North America;novel;Opioid;opioid abuse;opioid epidemic;Opioid Rotation;opioid use;opioid user;Oxycodone;Pathogenesis;patient population;Patients;patients who use opioids;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;Provirus Integration;Proviruses;Residual state;Shapes;Site;Sorting;Structure;T-Lymphocyte Subsets;Technology;Time;transcriptome sequencing;Viral;Viral Load result;Viral reservoir;Viremia;Virus Diseases;Virus Replication;whole genome

PROJECT_TITLE: Molecular profile of proviral reservoirs in HIV-infected drug users


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Tuberculosis (TB) is a major public health threat that spreads readily among humans or from animals to humans (termed zoonotic tuberculosis or zTB). Yet we lack accurate estimates of zTB risk, especially in high-TB-burden settings where the disease is endemic in both humans and livestock and where there are greater opportunities for transmission of zTB from animals to humans. Our innovative, rigorously designed, and first-of-its-kind study will fill this major knowledge gap by assessing the risks associated with zTB, and thereby enable the development of evidence-based approaches to reduce spillover from livestock to humans.

PI_NAMEs: BEHR, MARCEL A.;CONLAN, ANDREW JAMES KERR;KAPUR, VIVEK  (contact);MICHAEL, JOY SAROJINI;PALANIYANDI, KANNAN

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Animals;Base Sequence;Bovine Tuberculosis;burden of illness;case control;Cattle;Cattle Diseases;Cessation of life;Circulation;Consumption;Country;design;Development;Disease;Epidemiology;epidemiology study;Event;evidence base;Exposure to;Formulation;Genetic Variation;genome sequencing;Genotype;Gram-Positive Bacteria;health organization;Household;Human;improved;India;Infection;innovation;Knowledge;Livestock;low and middle-income countries;mathematical model;member;Meta-Analysis;Milk;Modeling;Molecular Epidemiology;Mycobacterium bovis;Mycobacterium tuberculosis complex;Organism;Pathway interactions;Persons;Planets;Proxy;Public Health;recruit;Reporting;response;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk mitigation;Risk Reduction;Sampling;Site;source localization;Surveys;systematic review;Testing;transmission process;Tuberculosis;unpasteurized;whole genome;World Health Organization;Zoonoses;zoonotic spillover

PROJECT_TITLE: Estimation of risk associated with zoonotic tuberculosis in South India

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Public Health Relevance. Through the proposed project, we seek to elucidate the molecular and genetic basis of neurological disorders in humans. Advancing the understanding of the genetic basis of disease, as well as the molecular mechanisms in the brain is a prerequisite to developing therapeutic strategies for cognitive dysfunctions. Thus, the proposed research is relevant to NIH’s mission to develop fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: RIAZUDDIN, SAIMA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adaptive Behaviors;Alleles;Artificial Intelligence;autism spectrum disorder;autosome;Biochemistry;Bioinformatics;Biological Assay;Brain;burden of illness;care costs;Cell Line;cell type;Cells;Cellular biology;Cellular Morphology;Clinical;Clinical assessments;Clinical Medicine;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive function;cohort;Collaborations;combinatorial;Complex;consanguineous family;Critical Pathways;Development;Diagnosis;diagnostic tool;disability;Disability phenotype;Disease;Economic Burden;Electrophysiology (science);Electroporation;embryo surgery;endophenotype;Enrollment;Etiology;experience;Extended Family;Face;Failure;Family;Family member;Family Sizes;Fibroblasts;fluorescence imaging;Funding;gene product;Genes;Genetic;Genetic Counseling;Genetic Determinism;Genetic Research;Genetic study;genetic variant;genome editing;Genomics;Grant;Health;Healthcare Systems;High Prevalence;Hippocampus;Human;imaging modality;Impaired cognition;improved;in silico;in utero;Inbreeding;Individual;innovation;Intellectual functioning disability;Investigation;Knowledge;Learning;Lesion;life time cost;live cell imaging;Massive Parallel Sequencing;Mediating;member;Mission;Molecular;Molecular Biology;Molecular Diagnosis;Molecular Genetics;Morphology;Mus;mutant;Mutation;nanoscale;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neurologic;Neurons;new therapeutic target;novel;patch clamp;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Population Heterogeneity;Positioning Attribute;postsynaptic;precision medicine;presynaptic;Prevalence;Preventive;Prognosis;prognostic;programs;protein expression;Proteins;public health relevance;Rattus;recruit;Research;Resources;response;Risk;Role;Sampling;screening;segregation;skills;social;Societies;socioeconomics;spatiotemporal;stem;Structure;subcellular targeting;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Syndrome;synergism;System;Testing;Therapeutic;Therapeutic Agents;Time;tool;transcriptomic profiling;ultra high resolution;United States;United States National Institutes of Health;Variant

PROJECT_TITLE: Genetics and Functional Studies of Autosomal Recessive Neurological Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


FUNDING_MECHANISM: OTHERS

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: Veterans with experiences of homelessness have increased risks for adverse mental health and substance abuse (MHSA) outcomes, including psychiatric hospitalization, overdose, and suicide. Given VA’s strong investment in improving all Veterans’ access to evidence-based MHSA treatment in primary care, it is critical to determine if homeless patient aligned care teams (H-PACTs) enhance MHSA services quality and outcomes, and to determine effective elements of other patient aligned care team (PACTs) caring for homeless- experienced Veterans. VA facility leaders need comparative information on the quality of MHSA services in H- PACTs versus standard PACT settings to help them decide whether to adopt, expand, or modify this promising model of care. Information on how H-PACTs and other PACTs coordinate with specialists in VA and community settings is needed to determine targets for intervention. Facility-specific information on factors contributing to improved MHSA services quality will guide quality improvement and implementation efforts.

PI_NAMEs: JONES, AUDREY L (contact)

PROJECT_TERMS: addiction;Adopted;care delivery;Caring;Clinical;Community Healthcare;Community Services;community setting;comparative;Data;design;Disease;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Elements;Emergency department visit;Enrollment;Environment;evidence base;experience;Fellowship;Future;Goals;Guidelines;Health;Health Services;Health Services Accessibility;high risk;Homelessness;Homogeneously Staining Region;implementation design;implementation efforts;implementation framework;implementation research;implementation science;implementation study;improved;improved outcome;innovation;inpatient psychiatric treatment;integrated care;Intervention;Interview;Investments;Laboratories;Lead;Leadership;Major Depressive Disorder;Measures;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;Methods;military veteran;Modeling;opioid overdose;opioid use disorder;Organizational Change;Outcome;Overdose;Patients;Performance;Population;Postdoctoral Fellow;Preparation;Primary Care;primary care services;primary care setting;primary care team;primary care visit;Process Measure;programs;Provider;Publishing;Qualitative Methods;Quality of Care;Recording of previous events;Recovery;Reporting;Research;Research Personnel;Research Priority;Risk;Science;service coordination;Services;Site;skills;Social Work;Specialist;Structure;Substance abuse problem;substance abuse treatment;Suicide;Surveys;Testing;therapy design;Time;Training;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Quality of Mental Health Services for Homeless Veterans in Primary Care Settings

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


PHR: The purpose of this award is to support the research, training and service activities of Dr. Matthew Maciejewski, who is a health economist, Research Career Scientist, and experienced Department of Veterans Affairs investigator. Over his 20-year HSR&D career, Dr. Maciejewski has led numerous research studies that improve our understanding of how best help Veterans manage their obesity or cardiometabolic conditions. This research is important because Veterans with obesity or multiple chronic conditions incur a disproportionate share of VA expenditures and population- based care models that effectively improve their health and health care are not yet established. He has contributed to the methods literature, played a leadership role in VA service and mentored fellows who have gone on to make major contributions.

PI_NAMEs: MACIEJEWSKI, MATTHEW L (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Advisory Committees;Ambulatory Care Facilities;Appointment;Award;bariatric surgery;Big Data;Body Weight Changes;Body Weight decreased;cardiometabolism;care fragmentation;career;career development;Caring;Chronic;Cities;Clinical Data;clinical predictors;cohort;Collaborations;Communities;Community Developments;Comparative Effectiveness Research;comparative effectiveness study;Competence;Complex;Contracts;copayment;cost;Data;design;economic outcome;editorial;effective care management;Electronic Health Record;Environment;Evaluation;evidence base;Expenditure;experience;Faculty;Freedom;Funding;Goals;Grant;Grant Review;Health;Health Services;Health Services Research;Health system;Healthcare;High Prevalence;high risk;Hospitalization;improved;insight;interest;International;Investigator-Initiated Research;Leadership;learning strategy;Literature;Measurement;meetings;member;Mental Health;Mentors;Methodology;Methods;military veteran;Mission;Modeling;multiple chronic conditions;National Institute of Drug Abuse;next generation;Obesity;obesity management;obesity risk;Operative Surgical Procedures;Outcome;Overweight;Patient Care;Patients;Pharmaceutical Preparations;Play;Policies;Population;population based;Positioning Attribute;Prevalence;Primary Care;primary care patient;Principal Investigator;Productivity;programs;Proxy;Quality of Care;Quasi-experiment;Research;Research Activity;research and development;Research Personnel;research study;Research Support;Resources;Risk;Role;Scientist;service learning;Services;social;Sodium Chloride;statistics;System;Training;United States Agency for Healthcare Research and Quality;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Weight maintenance regimen;Work

PROJECT_TITLE: HSR&D Senior Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


PHR: Veterans experience a high prevalence of peripheral artery disease (PAD), which is cholesterol build-up and blockages in the blood supply to the legs. A common symptom of PAD is pain in the legs or calves when walking. This pain often forces Veterans to limit their physical activity. The functional impairment caused by claudication promotes a sedentary lifestyle, placing Veterans with PAD at increased risk for heart disease. As such, the goals of therapy for PAD are: 1) maintain functional status, 2) manage claudication, and 3) to reduce cardiac events. Of the therapies, medical and invasive, recommended by practice guidelines, only one has the ability to simultaneously achieve all three treatment goals – exercise. Unfortunately, less than 10% of eligible Veterans participate in exercise rehabilitation programs due to a lack of availability and the burden of having to travel long distances to reach medical facilities.

PI_NAMEs: GUTIERREZ, JORGE ANTONIO ANTONIO (contact)

PROJECT_TERMS: Adherence;Adoption;Aerobic Exercise;Age;Award;Cardiac;cardiovascular risk factor;Caring;Cholesterol;claudication;cohort;common symptom;Coronary Arteriosclerosis;Data;Development;disease model;disorder risk;Eligibility Determination;Enrollment;Event;Exercise;exercise intervention;exercise program;exercise rehabilitation;Exercise Therapy;exercise training;experience;Feedback;Foundations;functional decline;Functional impairment;functional status;Future;Goals;health related quality of life;Health Services;Health Services Accessibility;Health Services Research;heart disease risk;High Prevalence;Home;implementation outcomes;implementation trial;Improve Access;improved;Intervention;Leg;Life Style;Location;longitudinal, prospective study;Measures;Medical;Mission;Modeling;Myocardial Ischemia;novel;Outcome Assessment;Pain;Pain in lower limb;Patients;Pattern;Perception;Peripheral arterial disease;Physical activity;Physical Function;Physical Performance;Pilot Projects;Practice Guidelines;preference;Premature Mortality;programs;prospective;Prospective, cohort study;Provider;Quality of life;Recommendation;Research;research and development;Research Design;Research Personnel;Research Priority;research study;Risk;Risk Factors;Role;Rural Community;satisfaction;sedentary lifestyle;Services;Site;skills;stem;Supervision;telehealth;therapy development;Training;Training Programs;Travel;Underserved Population;Vascular blood supply;Veterans;Walking;walking performance;walking speed;Work

PROJECT_TITLE: Telehealth to Improve Functional Status and Quality of Life in Veterans with PAD


PHR: Iraq and Afghanistan Veterans have higher rates of mental health conditions than other Servicemembers, perhaps related to longer and more frequent deployments. Given the overall high quality of mental health care provided at the VA, it is critical to understand why we see vast differences in enrollment rates in VA medical centers across the country as well as variability in engagement in care. As options for health care outside the VA have recently increased for this population, primarily though the Affordable Care Act’s Medicaid expansion, VA’s Choice Act and VA’s MISSION Act, Veterans’ health care has become more fragmented. To ensure that Veterans have access to high-quality integrated primary and mental health care, VA leaders need currently unavailable information to better understand enrollment and utilization patterns at their local facilities and regions. I propose to develop information and decision support tools to improve their understanding of and ability to impact VA enrollment and engagement in primary and mental health care.

PI_NAMEs: VANNEMAN, MEGAN ENFIELD (contact)

PROJECT_TERMS: Address;Affordable Care Act;Afghanistan;Age;Caring;Communities;community partners;community-level factor;Country;dashboard;Data;Decision Making;Doctor of Philosophy;Enrollment;experience;Facility Accesses;Feedback;Future;Goals;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;impression;improved;Individual;Informatics;innovation;insight;Integrated Health Care Systems;interest;Interview;Iraq;Leadership;Learning;Letters;Measures;Medicaid;Medical center;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Military Personnel;Modeling;Pattern;peer;Performance;pilot test;Population;Primary Health Care;Provider;Quality of Care;Recommendation;Research;Research Personnel;Resource Allocation;Resources;Sampling;satisfaction;Science;service member;Services;Statistical Models;support tools;System;Telephone Interviews;Testing;tool;Training;usability;Variant;Veterans;Wait Time;web site;Work

PROJECT_TITLE: Access to and Choice of VA or Non-VA Health Care by Veterans of Recent Conflicts


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Percutaneous coronary intervention (PCI), also known as “stenting,” is a common cardiac procedure that can improve survival and quality of life when used appropriately. The quality of PCI care varies among hospitals and physicians, and only 24% of elective procedures in VA are considered appropriate, potentially putting patients at risk without clear benefit. Nearly all PCI procedures are reported to national registries, but physicians receive little meaningful feedback about their care. This research will develop and test a peer learning intervention that facilitates clinician-to-clinician feedback and collaborative professional development. The intervention will provide actionable, personalized, and trusted feedback that promotes quality care and appropriate case selection. It will be designed with input from physicians and other stakeholders so that it is usable and acceptable. A successful peer review intervention could substantially reduce the number of patients receiving unnecessary stents and improve overall procedural quality.

PI_NAMEs: DOLL, JACOB A (contact)

PROJECT_TERMS: Acceleration;Adverse event;Agreement;arm;Attitude;behavior change;Cardiac;Cardiology;Cardiovascular system;career;career development;Caring;Clinical;Clinical assessments;Clinical Data;clinical practice;Clinical Trials;Cognitive;Complex;cost;Data;Data Reporting;design;Development;Doctor of Philosophy;effectiveness trial;Evaluation;evidence base;feasibility testing;Feedback;Frequencies;Goals;Growth;Health;Healthcare Systems;Hospitals;implementation outcomes;implementation science;improved;innovation;interest;Intervention;Interview;Investments;K-Series Research Career Programs;Lead;Learning;learning strategy;Measurement;Measures;Medicine;Mentorship;Methodology;Methods;Modeling;novel;Observational Study;Outcome;Patient Preferences;Patient Selection;Patients;peer;peer learning;Peer Review;percutaneous coronary intervention;Performance;Physicians;Pilot Projects;pilot test;preference;Procedures;Process;professor;programs;provider behavior;Qualifying;Qualitative Methods;Quality of Care;Quality of life;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Recommendation;Registries;Reporting;Research;Research Personnel;Resources;Risk;Scientist;Site;skills;sound;staff intervention;Stents;Structure;Surveys;System;Techniques;Testing;therapy design;Time;Training;trial design;Trust;Universities;usability;Veterans;Washington

PROJECT_TITLE: Peer learning to promote quality and appropriate use of percutaneous coronary intervention


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative: 1. In the US and throughout the world, the number of patients requiring orthognathic surgery for jaw  deformities, which involves skeleton, overlying soft tissue, or both, is escalating every ear. 2. Currently, while surgeons are able to accurately plan orthognathic surgery by virtually repositioning bony  segments to desired locations, they are still unable to practically predict the ultimate treatment outcomes  of orthognathic surgery, a desired postoperative facial appearance, during the surgical planning. 3. We are proposing to integrate outcome-driven and machine learning-based techniques together to first  estimate a desired postoperative face, and then plan the bony surgery, which will revolutionize the  surgical planning technique and enable clinicians to develop an optimal surgical plan based on both facial  and bony information, on-the-fly, using a single software in their routine clinical practice.

PI_NAMEs: GATENO, JAIME  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: 3D Print;Achievement;Algorithms;American;Anatomy;Appearance;Biomechanics;bone;Clinical;clinical practice;Complex;Computer software;Computer-Assisted Surgery;Congenital Abnormality;craniomaxillofacial;Databases;Defect;Deformity;design;Development;Ear;Elements;Face;Generations;Goals;Head;Hour;Impairment;improved;Individual;Jaw;Laboratories;Learning;learning network;Lip structure;Location;Machine Learning;mandible/maxilla;Methods;Modeling;Motivation;Movement;Operative Surgical Procedures;orthognathic;Outcome;Patient Care;Patients;personalized care;Planning Techniques;Positioning Attribute;Postoperative Period;Precision therapeutics;prevent;Process;Progress Reports;Psyche structure;psychologic;Quality of Care;Reconstructive Surgical Procedures;Reporting;Residual state;risk minimization;Running;Shapes;skeletal;Skeleton;Slide;soft tissue;Structure;success;Surgeon;surgery outcome;System;Techniques;Testing;Time;Trauma;Treatment outcome;treatment planning;Validation;virtual surgery;Work

PROJECT_TITLE: Outcome-Driven Approach to Minimize the Risks of Facial Distortion Following CMF Surgery

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Patients with post-traumatic stress disorder (PTSD) exhibit co-morbid alcohol use disorder (AUD) at far greater rates than the general population, but we have no effective therapies for these diseases when they present simultaneously. In Veteran populations the relationship between AUD and PTSD is even more prevalent as 63% of Veterans diagnosed with AUD are co-diagnosed with PTSD. Fibroblast growth factor 21 (FGF21) is a secreted endocrine molecule that signals to the brain to decrease alcohol consumption and genetic variation in genes encoding FGF21 and its receptor, β-klotho, are associated with increased alcohol consumption in humans. More recently we have observed that FGF21 also increases fear memory following chronic alcohol consumption in mice and propose to investigate how FGF21 signaling in the brain influences both alcohol consumption and fear to provide new therapeutic targets to treat Veterans suffering from both PTSD and AUD.

PI_NAMEs: FLIPPO, KYLE HARRINGTON (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;alcohol comorbidity;Alcohol consumption;alcohol response;alcohol use disorder;Alcohols;Amygdaloid structure;Brain;Calcium;career;career development;Chronic;chronic alcohol ingestion;Clinical;conditioned fear;Cues;Data;design;Development Plans;Diagnosis;Disease;effective therapy;Emotional;Endocrine;Exhibits;experience;experimental study;Extinction;Faculty;fear memory;Feedback;fibroblast growth factor 21;Fright;Funding;General Population;Genes;Genetic Variation;genomic locus;Goals;Healthcare;Heavy Drinking;Homeostasis;Hormones;Human;Image;Impairment;improved;in vivo calcium imaging;Knowledge;Leadership;Learning;Liver;Medical Records;Mentors;Mentorship;Metabolic;military veteran;Mus;neural;Neural Pathways;Neurons;new therapeutic target;Nucleus Accumbens;optogenetics;Patients;Population;Population Projection;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;preference;Property;receptor;Regulation;Research;Research Personnel;response;Rewards;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;symposium;Symptoms;Techniques;tenure track;Training;United States;Veterans;Writing

PROJECT_TITLE: Endocrine regulation of alcohol consumption and fear learning


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention

PHR: Project Narrative The goal of the proposed R01 is to advance the next generation of implementation research to end the HIV epidemic. MPIs Momplaisir, Gross, and Beidas partner with a network of clinics providing HIV care to experimentally test an adapted evidence-based practice, Managed Problem Solving, delivered by community health workers to improve viral suppression, retention, and reach within the City of Philadelphia. Our long-term goal is to improve retention in HIV care and viral suppression to achieve the benchmarks set forth by the EHE; the proposed trial has the potential to improve care in this network and produce findings that are generalizable to other health systems.

PI_NAMEs: BEIDAS, RINAD SARY;GROSS, ROBERT ;MOMPLAISIR, FLORENCE M (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Area;Back;behavior change;Behavior Therapy;Behavioral;Benchmarking;Caring;Cities;Client;Clinic;Clinical effectiveness;cluster randomized design;cohort;collaborative approach;Communication;Community Health Aides;Consolidated Framework for Implementation Research;Continuity of Patient Care;Counseling;County;Data;Decision Making;Dissemination and Implementation;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Elements;Eligibility Determination;Ensure;Epidemic;Ethnic Origin;Evidence based practice;experience;Future;Generations;Goals;health belief;Health Professional;Health system;HIV;HIV Infections;Hybrids;implementation cost;implementation efforts;implementation measures;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;Intervention;Interview;Language;Life Experience;Link;marginalized population;Medical Care Team;medication compliance;meetings;member;metropolitan;next generation;Outcome Measure;Patients;Persons;Philadelphia;primary outcome;Problem Solving;Process;Professional counselor;Protocols documentation;Public Health;Public Participation;Randomized;Research;retention rate;secondary outcome;Services;skills;Socioeconomic Status;Standardization;Testing;Training;treatment as prevention;treatment as usual;Trust;United States;United States National Institutes of Health;Viral

PROJECT_TITLE: Managed Problem Solving for ART Adherence and HIV Care Retention Delivered by Community Health Workers: A Stepped Wedge Hybrid Type II Effectiveness Implementation Trial


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: DERMATOLOGY

PHR: RELEVANCE (See instructions): Cathelicidin is a type of antimicrobial peptide known to be important to human disease since infection occurs when expression of this peptide is insufficient, and inflammation occurs when cathelicidin is too abundant. This project builds on a breakthrough discovery into the mechanism of action of cathelicidin to promote inflammation. Our approach seeks to better understand this process and explore potential strategies that can be exploited to treat disease.

PI_NAMEs: GALLO, RICHARD L (contact);NIZET, VICTOR

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 2019-nCoV;anti-microbial peptide;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;cathelicidin;cathelicidin antimicrobial peptide;Coagulase;Coupled;cytosolic receptor;Data;Disease;drug repurposing;drug resistant pathogen;Drug Synergism;Effectiveness;Elements;Endothelial Cells;Family;Family member;Fibroblasts;gene conservation;Gene Family;Host Defense;Human;human disease;hypoxia inducible factor 1;Immune;Immunity;Immunologics;immunoregulation;in vivo;Infection;Inflammation;Inflammatory;Instruction;Interferons;Investigation;keratinocyte;Knock-in Mouse;Leukocytes;Libraries;Ligand Binding;Lipids;Macrophage;Maps;Modification;Mus;mutant;neurotensin mimic 2;Nucleic Acids;Orthologous Gene;Parents;pathogen;Pathway interactions;Peptides;Physiological;Process;Property;Research;Resistance;RNA;Role;scavenger receptor;Sepsis;Signal Transduction;Skin;Staphylococcus aureus;Streptococcus pyogenes;Structure;synergism;Tertiary Protein Structure;Therapeutic;Transforming Growth Factor beta;Tretinoin;Update;uptake;UV induced;Virulence Factors;Work

PROJECT_TITLE: Cathelicidin in Skin Immunity


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: RELEVANCE (See instructions): The proposed studies will provide an essential foundation for investigating natural killer (NK) cell responses  to simian immunodeficiency virus (SIV) in rhesus macaques as a nonhuman primate model for HIV/AIDS  and will explore fundamental mechanisms by which NK cells differentiate virus-infected cells from healthy  cells and contribute to the control of immunodeficiency infection.

PI_NAMEs: EVANS, DAVID T (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Activated Natural Killer Cell;Acute;Address;Affect;AGR2 gene;Alleles;Amino Acid Substitution;Animal Model;Animals;Antibodies;Avidity;B-Lymphocytes;Binding;C Type Lectin Receptors;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Therapy;Cells;Chronic Phase;Cloning;Communicable Diseases;Cross Reactions;Data;Disease Progression;Epitopes;Fc Receptor;Flow Cytometry;Foundations;Genes;Genetic Polymorphism;Genome;HIV;HIV-1;HIV/AIDS;Human;Immune Evasion;Immunize;immunodeficiency;Immunogenetics;Immunoglobulin Genes;Immunoglobulins;Immunologics;in vivo;Individual;Infection;Instruction;Investigation;Killer Cells;Knowledge;Lectin Receptors;Ligands;Macaca;Macaca mulatta;Memory;Methods;MHC binding peptide;MHC Class I Genes;Modeling;Monitor;Mutation;Natural Killer Cells;nonhuman primate;novel;Outcome;pathogenic virus;Peptides;Persons;Phenotype;Primates;Property;Proteins;Reagent;receptor;Receptor Cell;Receptor Gene;Recombinants;response;Role;Shapes;Signal Transduction;SIV;Sorting;Stains;success;T-Cell Receptor;Testing;Viral;Viral Load result;Virus;Virus Diseases

PROJECT_TITLE: KIR and MHC Class I Immunogenetics in SIV Infection


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative We aim to evaluate the use of a digital platform for enhancing the clinical effectiveness and supporting the integration of a proven psychosocial rehabilitation intervention for patients with schizophrenia into the ongoing national roll out of comprehensive non-communicable disease services in primary care settings in India. Our study will break new ground by testing whether the digital platform yields added benefits for patients while supporting implementation and sustainability of community care for schizophrenia. Findings from our study can inform novel approaches for scaling up community care for schizophrenia in India and in other settings globally where access to these effective interventions remains alarmingly limited.

PI_NAMEs: MANJUNATHA, NARAYANA ;NASLUND, JOHN A (contact);TOROUS, JOHN

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;arm;Attention;Behavior;burden of illness;care coordination;care delivery;care systems;Caring;Chronic;Clinical;Clinical effectiveness;Collaborations;Communities;Community Health;Community Healthcare;community setting;Complex;cost;Cost Analysis;COVID-19 pandemic;Data;Devices;digital;digital data;digital intervention;digital phenotyping;digital platform;digital technology;disability;Disease;effective intervention;effectiveness/implementation trial;evidence base;functional outcomes;gaps in access;General Population;Government;Health;Health Services Accessibility;Health system;Hybrids;implementation outcomes;India;Individual;Infrastructure;Intervention;Life Expectancy;Life Style;Link;low and middle-income countries;Measures;Mediator;Medical;medical specialties;Mental Health;Monitor;mortality;National Institute of Mental Health;novel;novel strategies;Outcome;patient engagement;Patient Participation;patient population;Patient-Focused Outcomes;Patients;Persons;physical conditioning;Primary Care;primary care setting;programs;psychosocial;psychosocial rehabilitation;Randomized;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Research Infrastructure;Resource-limited setting;rural setting;scale up;Schizophrenia;secondary outcome;Services;Supervision;Symptoms;Testing;Time;Training;trial enrollment;uptake;urban setting

PROJECT_TITLE: Digital Implementation Support to Achieve Uptake and Integration of Task-Shared Care for Schizophrenia in Primary Care in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (02)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The proposed research is relevant to public health because it aims to increase participation in advanced biomedical research careers among students historically underrepresented in STEM. Providing opportunities for early biomedical research training to students from diverse backgrounds will benefit the U.S. by increasing preparedness to meet the nation’s biomedical research needs and supporting innovation in healthcare technology inclusive of the nation’s diverse pool of potential scientists.

PI_NAMEs: ALEXANDER, ANGELA  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Accountability;Address;African American;African American Women;arm;Award;Biology;Biomedical Engineering;Biomedical Research;bridge program;career;Career Choice;career development;Career Mobility;Clinical Research;cohort;Communication;Communities;Degree program;Development;diversity and inclusion;Doctor of Philosophy;Education;education planning;education research;Educational workshop;Elements;Engineering;Enrollment;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship Program;Goals;graduate school;graduate student;Health Benefit;Health Technology;Hour;Immersion;innovation;interest;Journals;Laboratories;Laboratory Research;Learning;Link;male;Manuscripts;matriculation;Medicine;member;Mentors;Modeling;Outcome;outreach;Participant;patient engagement;Patients;peer;peer coaching;physical science;Process;programs;Public Health;public health relevance;Publications;Readiness;Research;research and development;Research Personnel;Research Support;Research Training;Rotation;Scholars Program;Science;Scientist;Self Assessment;Self-reflection;skills;Societies;STEM field;Structure;student participation;Students;success;summer research;Sustainable Development;symposium;undergraduate student;Underrepresented Students;Universities;Visit;Writing

PROJECT_TITLE: Call Me Doctor ESTEEMED Scholars Program at Clemson University


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative In this proposal, we will study a radioligand therapy (RLT) that targets the prostate specific membrane antigen (PSMA), a molecule that is expressed on the majority of prostate cancer cells. PSMA RLT relies on two basic premises: targeting the radiation to PSMA and the radiosensitivity of the tissue to the deposited radiation. In this work, we will understand how PSMA expression is regulated and whether tumors respond because of intrinsic sensitivity to radiation or high doses of deposited radiation, which will allow us to develop co- administered therapies to potentiate the effect of PSMA RLT.

PI_NAMEs: FENG, FELIX YI-CHUNG;HOPE, THOMAS  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: absorption;Aftercare;androgen independent prostate cancer;Animal Model;Biological Markers;Biopsy;Blood;cancer cell;Cell Culture Techniques;Cell Line;Cell surface;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;CRISPR screen;Data Set;Deposition;Development;diagnostic value;Disease;Dose;dosimetry;effective therapy;FOLH1 gene;Gene Expression;Genes;Genome;genomic biomarker;genomic data;Genomics;Heterogeneity;Image;imaging biomarker;improved;Intervention;Knowledge;Lesion;Lutetium;Measures;Mediating;Modeling;Molecular;Neoplasm Circulating Cells;neoplastic cell;novel;novel therapeutics;Oligonucleotide Microarrays;Pathway Analysis;Pathway interactions;patient derived xenograft model;patient population;Patient Selection;Patients;pharmacologic;Phase III Clinical Trials;phase III trial;Positron-Emission Tomography;predicting response;prospective;prostate cancer cell;PSA level;Publishing;Radiation;radiation response;Radiation Tolerance;Radioisotopes;radioligand;radiological imaging;Randomized;receptor;response;Sampling;Serology;single photon emission computed tomography;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;transcriptome;transcriptomics;Treatment Efficacy;treatment response;tumor;uptake;Work

PROJECT_TITLE: MELT: Modulation of PSMA Expression for Lutetium Therapy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative / Public Health Relevance This project lays the foundation for improving diagnostics, rehabilitation, and ultimately functional outcomes and quality of life of the hundreds of thousands of people whose lives are negatively impacted by a brain injury that leaves them with often subtle, yet disabling visuospatial deficits. The findings will allow us to develop a comprehensive yet bedside-compatible assessment for core visuospatial deficits, identify visuospatial tests that are particularly sensitive to right-brain injury and thus can complement current screening tools (which underestimate right-brain injury), and pinpoint visuospatial deficits that are strongly linked to functional outcomes and should thus become the focus of rehabilitation efforts. Functional neuroimaging results will guide the development of non-invasive neurostimulation protocols to augment the effect of behavioral treatments by promoting adaptive patterns of functional brain organization.

PI_NAMEs: GREENWALD, ANNA  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Activities of Daily Living;Age;Agreement;Anatomy;Aphasia;aphasia rehabilitation;Apraxia;Area;Attention;Attentional deficit;base;Behavior Therapy;Brain;Brain Injuries;Brain region;Characteristics;Classification;Clinical Trials;Cognition;Complement;Confounding Factors (Epidemiology);Contralateral;Control Groups;Data;Development;Diagnosis;Diagnostic;Diagnostic Sensitivity;diagnostic tool;Disabling;Dissociation;Education;Eligibility Determination;eligible participant;Executive Dysfunction;Factor Analysis;Foundations;Functional Magnetic Resonance Imaging;functional outcomes;hemiparesis;Heterogeneity;Impairment;improved;individualized medicine;Inferior;Injury;Intervention;Judgment;language impairment;Left;Length;Lesion;Linear Regressions;Link;Location;Long term disability;Long-Term Survivors;Magnetic Resonance Imaging;Manuals;Maps;Memory;Methods;Modeling;Motor;Nature;neural;neuroimaging;Neurologic;noninvasive brain stimulation;novel;Outcome;Parietal;Participant;Patient Self-Report;Patients;Pattern;Perception;Performance;Persons;post stroke;Predictive Value;Prognosis;Protocols documentation;public health relevance;Quality of life;Recovery;Regression Analysis;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Personnel;Resolution;Rest;Review Literature;Screening procedure;Site;spatial neglect;Stimulus;Stress;Stroke;stroke outcome;stroke survivor;stroke symptom;Survivors;Symptoms;Task Performances;Test Result;Testing;Translating;Visuospatial

PROJECT_TITLE: Visuospatial deficits after stroke: Towards better classification, diagnostics, and rehabilitation.

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Precision Medicine;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Urge urinary incontinence is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will further investigate the brain mechanisms involved in continence by evaluating brain changes after treatment by an anticholinergic drug to reduce urine leakage. This will expand our current knowledge of how the brain controls the bladder, better characterize the drug action mechanism and suggest ways in which we can better target treatment.

PI_NAMEs: CLARKSON, BECKY D (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Address;Affect;Aftercare;aged;Anti-Cholinergics;Area;arterial spin labeling;Behavior Therapy;Biofeedback;Bladder;Bladder Control;Bladder Dysfunction;blood-brain barrier permeabilization;Brain;brain control;brain dysfunction;Brain region;Cerebrum;Characteristics;Cholinergic Agents;Clinical;clinical practice;Compensation;Complement;cost;Cross-Over Trials;Data;design;Development;Diffusion Magnetic Resonance Imaging;Disease;drug action;Drug Design;drug efficacy;drug withdrawal;Elderly;Extravasation;Frustration;Image;Impairment;improved;Incontinence;insight;Insula of Reil;Intervention;Investigation;Knowledge;Magnetic Resonance Imaging;Measures;Medial;Mediating;Mediator;Methods;Micturition Reflex;micturition urgency;Midbrain structure;Modeling;Muscarinics;Neurosciences;new therapeutic target;novel therapeutics;older adult;Older Population;Pattern;Pelvic Floor Muscle;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Pilot Projects;Placebo Control;Placebo Effect;Placebos;predicting response;predictive modeling;Prefrontal Cortex;Quality of life;Randomized;Reaction;Refractory;Relapse;Resistance;Resolution;responders and non-responders;response;Role;Scientist;Sorting;Spasm;targeted treatment;Techniques;Testing;Therapeutic;Training;treatment effect;treatment response;Urinary Incontinence;Urine;Withdrawal;Woman;Work

PROJECT_TITLE: Investigation of brain mechanisms involved in Urgency Urinary Incontinence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Prostate Cancer;Radiation Oncology;Urologic Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses the appropriate use of shorter radiation treatments (called “hypofractionation”) for breast and prostate cancer, a critical step to improving access to high-value patient-centered cancer care. This research proposal will assess variation across the United States in adoption of hypofractionation, and methodically evaluate and pilot test implementation strategies to improve adoption of hypofractionation in a community-based clinical practice setting. The results of this work will generate fundamental knowledge to inform healthcare leaders and policymakers about effective methods to facilitate adoption of evidence-based cancer care, thereby improving access to shorter radiation treatments that improve quality of life and reduce the burden of cancer treatment for patients.

PI_NAMEs: GILLESPIE, ERIN FAYE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;behavioral economics;Cancer Burden;cancer care;Cancer Control;cancer therapy;career development;Caring;Clinical Pathways;clinical practice;Communities;community partners;cost;Coupled;Data Set;Decision Making;Deimplementation;density;design;Development;deviant;evidence base;Evidence based practice;experience;Faculty;Feedback;Foundations;Funding;Goals;Guidelines;Health Policy;Health Services Research;Healthcare;Hospitals;human centered design;implementation evaluation;implementation science;implementation strategy;Improve Access;improved;Incentives;Individual;Influentials;insight;Institution;Knowledge;large datasets;Leadership;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Medicare;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Methodology;Methods;Outcome;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Peer Review;Performance;Physicians;pilot test;Policy Maker;Population Study;practice setting;Preparation;prospective;Prostate;Public Health;Publications;Publishing;Quality of life;Radiation;Radiation Oncologist;Radiation Oncology;Radiation therapy;randomized trial;randomized, clinical trials;Reporting;Research;Research Personnel;Research Proposals;Resources;Scientist;skills;social;System;Taxes;Testing;theories;Training;Translating;United States;United States National Institutes of Health;uptake;Variant;Work

PROJECT_TITLE: Leveraging implementation science to accelerate adoption of shorter-course radiation for breast and prostate cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Aging causes shoulder tendons to deteriorate for all people, but for people with spinal cord injuries who use a manual wheelchair, shoulder tendons will tear and cause pain at a younger age and higher rate than people without physical disabilities. Understanding what factors worsen the health of the shoulder tendons will inform early interventions to protect shoulders and keep them free from pain. This study will follow two groups of people, manual wheelchair users and able-bodied adults, while looking for differences in how they use their arms, the medications they use, and their general health indicators to determine which of these factors are related to worsening tendon tears in the shoulder.

PI_NAMEs: MORROW, MELISSA M. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adult;Affect;Age;age related;Aging;arm;Attention;Chronic;Clinical;clinical care;clinical diagnosis;clinical risk;cohort;Cohort Studies;comorbidity;Coupled;Data;Deceleration;Deterioration;Development;disability;Disease;Disease Progression;dosage;Early Intervention;evidence based guidelines;Exhibits;Exposure to;Female;follow-up;Functional disorder;Future;Goals;Guidelines;Health;high risk;improved;Individual;Intervention;Intrinsic factor;Investigation;Knowledge;Lesion;Life;Literature;longitudinal, prospective study;Magnetic Resonance Imaging;Manual wheelchair;Measures;morphogens;Movement;Natural History;normal aging;Pain;Pain Free;Pathology;Patient Education;Patients;Persons;Pharmaceutical Preparations;physically handicapped;Population;population based;Population Study;Posture;preservation;prevent;Recovery;rehabilitation strategy;Risk;Risk Factors;Role;Rotator Cuff;rotator cuff tear;sex;Shoulder;Shoulder Pain;Spinal cord injury;Structure;Tendinopathy;Tendon structure;Time;Translating;Upper Extremity;wearable sensor technology;Wheelchair user

PROJECT_TITLE: Natural History of Shoulder Pathology in Wheelchair Users

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: NARRATIVE Reno, Nevada is impacted by smoke plumes from wildfires and prescribed burns. We will measure and model the pollutants in these smoke plumes, and we will estimate associations of smoke pollutants with maternal, child, and adult acute health outcomes. Our goals are to improve smoke pollutant modeling for public health and to better understand the health impacts of different types of fires.

PI_NAMEs: STRICKLAND, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Adult;Aerosols;Age;aged;Aging;Air;Air Pollutants;Airway Disease;American;Asthma;Atmosphere;Biomass;biomass fuel;Blood Pressure;Bronchitis;Burn injury;Calibration;California;Carbon;Carbon Black;cardiorespiratory fitness;Cardiovascular Diseases;Categories;Child;Chronic Obstructive Pulmonary Disease;Cities;Communities;Complex;Computerized Medical Record;Congestive Heart Failure;Data Set;Databases;Development;Ecosystem;epidemiological model;epidemiology study;Event;evidence base;experimental study;Exposure to;fine particles;Fire - disasters;forest;Future;Gases;Goals;Grasslands;Health;Health Personnel;health warning;Heterogeneity;improved;innovation;interest;Ischemic Stroke;Laboratories;land use;Measurement;Measures;Modeling;Myocardial Infarction;Natural Resources;Nevada;Outcome;oxidation;particle;Patients;Phase;Pneumonia;pollutant;Population;population health;Public Health;Public Health Applications Research;Public Policy;Research Institute;Resources;Risk;Smoke;Source;System;Visit;Wildfire

PROJECT_TITLE: Associations of smoke from wildfires and prescribed burns with cardiorespiratory health outcomes in Reno, NV

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: MULTNOMAH COUNTY HEALTH DEPARTMENT

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Our study will contribute to the evidence about effective public policy by local governments within states that have legalized retail cannabis by providing a systematic description of 1) local (i.e., county/city) policies to regulate cannabis and local market environments (e.g., density of retailers and sales activity); 2) the association between local cannabis policies, prices and market activity and health outcomes among youth, pregnant women and adults; and 3) further association with alcohol, tobacco and opioid outcomes among youth, pregnant women and adults.

PI_NAMEs: DILLEY, JULIA ANN (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: Address;Adult;Advocate;Affect;Alcohol consumption;Alcohols;Attitude;Behavior;behavior influence;Behavioral;Breast Feeding;Cannabis;Cannabis policy;Cannabis retail;cannabis use behavior;Child Rearing;Cities;Collaborations;Communities;County;Data;Data Reporting;density;Dependence;Drug abuse;Effectiveness;Environment;evidence base;Exposure to;Frequencies;Funding;Grant;Health;Health Services;high school;Hospitalization;Hospitals;Knowledge;Learning;Legal;Licensing;Local Government;Marijuana;Marijuana Dependence;marijuana legalization;marijuana use;Marketing;Modeling;Monitor;Mothers;National Institute of Drug Abuse;Opioid;Oregon;Outcome;Pacific Northwest;Pattern;Policies;Policy Maker;Policy Research;population based;Population Surveillance;Pregnancy;pregnant;Pregnant Women;Preparation;Prevalence;Price;Productivity;Public Health;Public Policy;Publishing;Quasi-experiment;Recommendation;Recreation;Regulation;Research;response;Risk Assessment;Role;Sales;School-Age Population;Side;Social outcome;Social Work;substance use treatment;surveillance data;System;Taxes;Time;Tobacco;Tobacco use;Variant;Visit;Washington;Woman;Youth

PROJECT_TITLE: Dynamics of Cannabis Market Environment Changes and Public Health Effects after Legalization: The Role of Local-Level Regulation Beyond the Short-Term in the Pacific Northwest

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed project will develop a novel technology to measure cortical plate and subplate thickness in the human fetal brain using in vivo MRI, which in turn will enable us to understand trajectories (temporal dynamics) and inter-subject variabilities of fetal cerebral growth. The technology for fetal cortical and subplate thickness measurement will lay the foundation for clinical applications of fetal brain MRI analysis in many developmental disorders and extend the field of developmental brain imaging research. This study will provide a meaningful biomarker that could lead to greater insight into the mechanisms of normal and altered in utero brain development, allowing assessment of the impact of maternal exposures and informing strategies for future in utero therapies.

PI_NAMEs: IM, KIHO  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 37 weeks gestation;Adult;Algorithms;Animal Model;Area;Autopsy;axon guidance;Biological Markers;Brain;Brain Diseases;Brain imaging;brain magnetic resonance imaging;Cell Size;Cerebrospinal Fluid;Cerebrum;Child;clinical application;Clinical Research;Cognition Disorders;cognitive function;computational platform;contrast imaging;convolutional neural network;Corpus Callosum;Cortical Malformation;Data;Data Set;deep learning;density;Development;developmental disease;Disease Progression;fetal;Fetal Development;Fetus;Foundations;Future;Gene Expression;Gestational Age;gray matter;Growth;Head;Human;human fetal brain;Hypoxic-Ischemic Brain Injury;Image;in utero;in vivo;insight;Knowledge;Magnetic Resonance Imaging;Manuals;Maternal Exposure;Measurement;Measures;Methods;Microgyria;Modeling;Morphologic artifacts;Motion;Mutation;Myelin;Neural Network Simulation;neuroimaging;neuron loss;Neuronal Differentiation;new technology;novel marker;Online Systems;Onset of illness;Pattern;Perinatal Hypoxia;postnatal;Pregnancy;prenatal;prenatal therapy;reconstruction;Research;Resolution;Shapes;Site;spatiotemporal;Structure;Study models;Surface;Synapses;Techniques;Technology;Testing;Thalamic structure;Thick;Thinness;Tissues;tool;Translations;Variant

PROJECT_TITLE: Measuring cortical plate and subplate thickness in the human fetal brain from magnetic resonance images

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lineage plasticity is an emerging mechanism of therapeutic resistance in advanced prostate cancer. As more men are treated with next-generation androgen receptor targeted therapies, the incidence rate of resistant disease is on the rise. These studies aim to understand the molecular mechanisms underlying the process of lineage plasticity, identify biomarkers of cells that are likely to develop resistance to therapy, and propose new strategies to improve outcomes for prostate cancer patients.

PI_NAMEs: BRADY, NICHOLAS JAMES (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Adenocarcinoma;Adenocarcinoma Cell;advanced prostate cancer;Affect;Allografting;androgen independent prostate cancer;Androgen Receptor;Androgens;Back;Bioinformatics;Biological Models;biomarker identification;Cancer Patient;career development;Castration;Cells;ChIP-seq;Chromatin;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Data;deprivation;Development;Disease Resistance;Educational workshop;effective therapy;Environment;enzalutamide;Epigenetic Process;Epithelial Cells;Etiology;Exposure to;EZH2 gene;Fostering;Future;gene editing technology;Gene Expression;Genes;Genetic Transcription;Genetically Engineered Mouse;genome editing;Genomics;Histologic;Histology;Human;human model;improved outcome;In Vitro;Incidence;insight;Institution;Learning;lentivirally transduced;Malignant neoplasm of prostate;Mediating;Medicine;men;Molecular;mouse model;Mus;Mutate;Mutation;MYCN gene;neoplastic cell;Neuroendocrine Cell;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;Neurosecretory Systems;next generation;novel;novel therapeutic intervention;Organoids;Outcome;overexpression;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;Population;Positioning Attribute;potential biomarker;prevent;Process;Prostate;Prostate Adenocarcinoma;prostate cancer model;Prostatic Neoplasms;RB1 gene;Research;research and development;Research Personnel;Resistance;Resistance development;Role;Selection Criteria;Shapes;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;skills;small cell lung carcinoma;success;symposium;targeted treatment;therapeutic development;therapy resistant;TP53 gene;transcription factor;tumor;tumor heterogeneity;Up-Regulation;Withdrawal;Work;Xenograft Model

PROJECT_TITLE: Targeting drivers of tumor heterogeneity to block the progression to neuroendocrine prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]