ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Although viral myocarditis is a significant cause of morbidity and mortality worldwide, the mechanisms underlying viral myocarditis are not fully defined. The goal of the experiments described in this proposal is to define how pyroptosis, a pro-inflammatory mechanism of cell death, contributes to reovirus myocarditis. Defining the mechanisms of myocarditis induction is essential to an understanding the systemic disease and may foster development of therapeutics for treating viral heart infections.

PI_NAMEs: BOEHME, KARL W (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Animal Model;Apoptosis;Cardiac;Cardiac Myocytes;Cell Death;Cell Death Induction;cell killing;Cell membrane;cell type;Cells;Cessation of life;Child;Clinical;Communication;cytokine;Cytolysis;Data;Development;Disease;experimental study;Family;Fostering;Foundations;Future;Goals;Heart;heart cell;Heart Diseases;IL18 gene;Immune;immune function;Immune response;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Interleukin-1 beta;Lytic;Mammalian Orthoreovirus;Mediating;member;Morbidity - disease rate;mortality;Mus;Myocarditis;N-terminal;neonatal mice;neonate;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Process;Production;Reovirus;Reovirus Infections;Reporting;Research;response;Role;Rupture;Signal Pathway;Signal Transduction;Stimulus;Study models;Systemic disease;systemic inflammatory response;therapeutic development;Tissues;Viral;viral myocarditis;Viral Pathogenesis;Virulence;Virulent;Virus;Virus Diseases;Virus Replication;Work;young adult

PROJECT_TITLE: Reovirus induction of host inflammatory responses

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: SUITER, SARAH  V (contact)

PROJECT_TERMS: Achievement;Affect;American Indians;Area;Automobile Driving;Award;Benchmarking;Biomedical Research;Black race;career;career development;Climate;cohort;Collaborations;Community of Practice;comparison group;dashboard;Data;Data Analyses;Data Collection;Data Reporting;Decision Making;design;Development;Development Plans;development policy;Discipline;Documentation;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Evidence based practice;Faculty;faculty mentor;Faculty Recruitment;Feedback;Fostering;Gender;Goals;Grant;Growth;implementation evaluation;improved;indexing;Individual;Inequality;Inequity;Institution;Institutional Policy;Interview;Investments;Knowledge;Latinx;Leadership;lens;Measures;Medicine;meetings;member;Mentors;Methods;Minority Groups;Modeling;Monitor;Morehouse School of Medicine;Outcome;outcome disparities;Pacific Islander;Paper;parity;Participant;Pathway Analysis;peer;Persons;Policies;Population;Positioning Attribute;Process;programs;Publications;Publishing;Race;racial diversity;racial minority population;Reporting;Research;Resources;Sample Size;satisfaction;Scholarship;Schools;Science;Scientist;Services;skills;Social Network;success;Surveys;symposium;Teacher Professional Development;Testing;theories;Time;tool;Training;Universities;Voice;Wages;Work

PROJECT_TITLE: Evaluation Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-W]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PHR: PROJECT NARRATIVE  This project will develop synthetic scavenger medical countermeasures (MCMs) for fentanyl. There is a growing need for new MCMs that can be used in conjunction with receptor antagonists like naloxone to overcome the limitations of current treatments, such as re-narcotization, low efficacy against potent opioids (e.g., fentanyl) and too high dosing. This exploratory research project will develop low molecular weight, highly potent synthetic scavengers of synthetic opiates as a novel MCM strategy that can be broadly applied to many Pharmaceutical Based Agents (PBAs).

PI_NAMEs: LIU, XIAOHE  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: absorption;Agonist;antagonist;Antibodies;Antidotes;Asialoglycoprotein Receptor;Binding;Biological;Biological Assay;bioscavenger;Blood;Butyrylcholinesterase;Canada;carfentanil;Cell Line;Cells;Cellular Assay;Characteristics;Chemical Weapons;Classification;Clinical;Cocaine;combat;combinatorial;Complex;coping;Country;Data;design;Development;Disadvantaged;Dose;drug discovery;Drug Kinetics;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemic;Evaluation;Exhibits;experimental study;Fentanyl;fentanyl overdose;fentanyl use;Fiber Optics;follow-up;Future;Half-Life;Heroin;Hour;Human;Hydrocortisone;immunogenicity;improved;In Vitro;inhibitor;innovation;innovative technologies;Interferometry;Interleukin 6 Receptor;Interleukin-6;Intramuscular Injections;intravenous administration;Iran;Kinetics;Lead;Libraries;Mammalian Cell;medical countermeasure;member;Molecular Weight;Monoclonal Antibodies;Morphine;mouse model;mu opioid receptors;Mus;Naloxone;naloxone dosing;nerve agent;new technology;novel;novel therapeutics;Opioid;opioid abuse;Opioid agonist;Opioid Antagonist;opioid mortality;opioid overdose;opioid withdrawal;organophosphate poisoning;Organophosphates;Outcome;Overdose;overdose death;pharmacokinetic characteristic;pharmacologic;Pharmacologic Substance;Precipitation;preclinical efficacy;prevent;programs;Property;Prophylactic treatment;protein protein interaction;Proteins;Public Health;Publishing;Rapid screening;Rattus;receptor;receptor binding;Reporting;Research;Research Project Grants;Risk;Russia;SARS-CoV-2 B.1.1.7;Scanning;screening;Site;small molecule;Structure;Substance Withdrawal Syndrome;success;Supplementation;symposium;Symptoms;synthetic opioid;Technology;Testing;TNF gene;tool;Toxic effect;Translations;United States;Ventilatory Depression

PROJECT_TITLE: Synthetic Scavenger Medical Countermeasures for Fentanyl

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Immunization;Immunotherapy;Orphan Drug;Rare Diseases;Wound Healing and Care

ORG_CITY: COLLEGE STATION

ORG_NAME: ASTERO ERADO INC

ORG_STATE: TX

PHR: PROJECT NARRATIVE Treatments that are currently available for antibody-mediated diseases such as the autoimmune blistering diseases, pemphigus vulgaris (PV) and pemphigus foliaceus (PF), are generally immunosuppressive, are associated with adverse events and/or have limited efficacy. To address these issues, in this application we propose to develop a novel treatment that selectively removes the autoreactive antibodies which are involved in the disease process, without affecting the levels of other antibodies that are important for protection against infectious agents such as bacteria and viruses. This approach has the potential to be a game-changer for the clinical management of PV and PF.

PI_NAMEs: KANNANGANAT SIDHARTHAN, SUNIL  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acantholysis;Address;Adhesions;Adrenal Cortex Hormones;Adult;Adverse effects;Adverse event;Affect;Aftercare;Antibodies;Antibody Therapy;Antigens;Applications Grants;Autoantibodies;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Bacteria;Binding;Biological Assay;Bulla;Cell Surface Receptors;Chimeric Proteins;Chronic;Clinic;Clinical;Clinical Management;Combined Modality Therapy;commercialization;Deglutition;design;desmoglein 1;desmoglein III;Desmosomes;Development;Disadvantaged;Disease;Dose;Endothelial Cells;Engineering;Excision;experimental analysis;Funding;Gamma globulin;General Population;Generations;Goals;Hypertension;IgG autoantibodies;Immune Tolerance;Immunoglobulin G;Immunosuppression;Immunosuppressive Agents;improved;in vivo;Infection;infection risk;Infectious Agent;Inflammatory;Infusion procedures;Intravenous;keratinocyte;Kupffer Cells;Laboratories;Lead;Lesion;Liver;Lysosomes;Mediating;mortality;mortality risk;mouse model;Mucous Membrane;mycophenolate mofetil;Names;new technology;novel;novel strategies;novel therapeutics;oligodendrocyte-myelin glycoprotein;Osteoporosis;Pain;Pathogenicity;Patients;Pemphigus;Pemphigus Vulgaris;Phase;Plasmapheresis;Procedures;Process;Property;Quality of life;Reaction;Reagent;Relapse;relapse patients;relapse prevention;Research;Research Design;rituximab;Role;Sampling;Serum;side effect;Skin;skin lesion;Specificity;Steroids;Surface;targeted delivery;targeted treatment;Technology;Texas;Therapeutic;therapy development;Tissues;Translating;Universities;Virus;ward;Work

PROJECT_TITLE: Novel treatments for Autoimmune Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Although chemosensory dysfunction has serious physical and mental health consequences, loss of smell and taste was largely under-appreciated prior to COVID-19, having few evidenced-based interventions available for treatment. The present study will address this critical gap in healthcare by examining the use of smell training and trigeminal nerve stimulation to enhance olfactory function and associated impairments in mood and cognition. This study has the potential to significantly advance an area of science largely ignored, as well as improve the current standard of care for those suffering with chemosensory dysfunction.

PI_NAMEs: CORTESE, BERNADETTE  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adult;Aftercare;Anosmia;Area;Attention;Brain;Cognition;Cognitive;cognitive function;combinatorial;Communication;COVID-19;COVID-19 associated anosmia;COVID-19 treatment;design;Detection;Development;Dropout;Drowsiness;efficacy evaluation;Electric Stimulation;Etiology;Evidence based intervention;Evidence based practice;Evidence based treatment;executive function;Functional disorder;Healthcare;Home;Human;hyposmia;Impaired cognition;Impairment;improved;improved outcome;Infection;Intervention;Investigation;Long COVID;Mental Health;Methods;Moods;National Institute on Deafness and Other Communication Disorders;Natural regeneration;Neurons;neuropsychiatric disorder;neuropsychiatric symptom;neuroregulation;non-compliance;noninvasive brain stimulation;novel;Pain Free;Paraosmias;physical conditioning;post-COVID-19;Psychophysics;Publishing;Qualifying;Randomized, Controlled Trials;Recovery;Research;response;SARS-CoV-2 exposure;Science;Sensory;Sleep;sleep quality;Smell Perception;Speed;standard of care;Strategic Planning;symptomatology;Symptoms;Taste Perception;Training;Treatment Efficacy;Trigeminal nerve structure;Trigeminal System;Work

PROJECT_TITLE: A randomized controlled trial of smell training and trigeminal nerve stimulation in the treatment of COVID-related persistent smell loss

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NM-INSPIRES Overall Project Narrative This P30 Core NIEHS will support basic and translational research, and community engagement in New Mexico. The Center will support NIH-funded investigators examining mechanisms of environmentally-induced cancers, immune and infectious diseases, and cardiopulmonary diseases of great public health importance,

PI_NAMEs: BLOSSOM, SARAH J (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Air;Annual Reports;Area;Arsenic;Autophagocytosis;Basic Science;Biology;Biometry;Birth;carcinogenesis;Cardiopulmonary;Center for Translational Science Activities;Centers of Research Excellence;Chemistry;Child Health;Clinical Research;Clinical Sciences;Cohort Studies;Communicable Diseases;Communication;Communities;community engagement;Community Health;community partners;Complex;Complex Mixtures;Comprehensive Cancer Center;Core Facility;Data Science Core;Development;Discipline;Disease;Emergency Situation;Environment;environment related cancer;Environmental Exposure;Environmental Hazards;Environmental Health;environmental justice;Environmental Science;Exposure to;Extramural Activities;Focus Groups;Fostering;Funding;Gases;Genomics;Goals;Health;health equity;Health Sciences;Home;hydraulic fracturing;Immune System Diseases;Immunology;implementation science;Inflammation;Infrastructure;Inhalation;innovation;International;Investments;Leadership;Measures;Medicine;member;Mentorship;Metabolism;Metal exposure;Metals;Methods;Mexico;Mining;multimodality;National Institute of Environmental Health Sciences;Native American population;nature center;Navajo;New Mexico;next generation;novel;novel strategies;Oils;Outcome;outreach;Pilot Projects;Population Heterogeneity;Population Study;programs;Public Health;Pueblo Race;Pulmonary Heart Disease;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Services;social media;Strategic Planning;Structure;success;Superfund;synergism;Technology;Time;tool;Toxicology;Training;Translational Research;translational study;Tribes;Underserved Population;United States National Institutes of Health;Universities;Uranium;Work

PROJECT_TITLE: New Mexico Integrative Science Program Incorporating Research in Environmental Sciences (NM-INSPIRES)


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Administrator;Affect;Applications Grants;Area;Award;career development;Career Mobility;citizen science;Clinical;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Core Facility;Data;Decision Making;Dedications;design;Disadvantaged;Disease;Education;Effectiveness;Employment;Ensure;Environment;Environmental Health;Environmental Impact;Environmental Risk Factor;Environmental Science;Etiology;Event;Focus Groups;Goals;Group Meetings;Health;health inequalities;Health Sciences;Individual;Infrastructure;innovation;interest;Journals;Leadership;Malignant Neoplasms;Measures;meetings;member;Metabolic Diseases;Metals;Mining;Mission;Monitor;New Mexico;Newsletter;operation;Outcome;Pharmacy facility;Pilot Projects;Play;Population;Process;Productivity;Program Development;programs;Publications;Pulmonary Heart Disease;Records;Research;Research Personnel;Resource Sharing;Resources;Role;Rural Population;Science;Scientist;Series;skills;Socioeconomic Status;Strategic Planning;success;Time;Training;Translations

PROJECT_TITLE: Administrative Core


PI_NAMEs: MACKENZIE, DEBRA  (contact)

PROJECT_TERMS: Address;Animals;Basic Science;Biological;Cancer Biology;Cardiovascular Diseases;Clinical;Collaborations;commune;Communicable Diseases;Communication;Communities;Community Health;Complex;Consultations;Core Facility;Data;design;DNA Damage;DNA Repair;Ensure;Environmental Exposure;Environmental Health;Environmental Science;Epidemiology;experience;Gases;Goals;Health;Health Policy;Health Sciences;Human;hydraulic fracturing;Immunology;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;instrumentation;interest;Knowledge;Laboratories;member;metabolomics;Metal exposure;Metals;Mexico;Mining;Molecular Toxicology;National Institute of Environmental Health Sciences;neurodevelopment;New Mexico;Nutritional Science;Oils;Outcome;Pharmacologic Substance;Population;Predisposition;programs;Public Health;Publications;PubMed;Research;Research Design;Research Personnel;research study;Research Support;Resources;Respiratory Disease;response;Risk Factors;Sampling;Science;Services;Site;Source;text searching;Toxicology;Translational Research;translational research program;translational study;tribal community;Uranium;wasting;Work

PROJECT_TITLE: Integrated Health Sciences Facility Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Kainate receptors are ionotropic glutamate receptors important in synapse regulation and have been linked to neurological deficits including epilepsy, autism, mental retardation, and schizophrenia, making them important as pharmacological targets. Postsynaptic kainate receptors have been found to create a trans-synaptic junction with presynaptic Neurexin3β and extracellular scaffolding C1q-like protein as an intermediate. This proposal aims to investigate the functional and structural properties of this junction in order to understand the role this trans-synaptic junction plays in neuron function and correlate this junction with known behavioral deficits.

PI_NAMEs: GONZALEZ, CUAUHTEMOC ULISES (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: 3-Dimensional;autism spectrum disorder;Behavior;Behavioral;Binding;Biological;biophysical properties;Calcium;Calcium Channel;Calcium Signaling;Cations;Cells;Complement 1q;Complex;Concanavalin A;Coupling;Cryoelectron Microscopy;delta receptors;desensitization;Disease;Doctor of Philosophy;doctoral student;Electron Microscopy;Electrons;Electrophysiology (science);Epilepsy;experimental study;extracellular;Extracellular Domain;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Foundations;Future;Glutamate Receptor;Glutamates;Glycine;insight;Investigation;Ion Channel;kainate;Kainic Acid Receptors;Knowledge;Lead;Learning;ligand gated channel;Link;macromolecule;Manic;Measurement;Measures;Mediating;member;Membrane;Membrane Proteins;Mental Retardation;Methodology;Methods;Molecular Conformation;Morphology;mossy fiber;Neurocognitive Deficit;Neurologic Deficit;Neurons;neurotransmission;neurotransmitter release;novel;Orphan;Permeability;pharmacologic;Phase;Physiological;Plant Lectins;Play;Postdoctoral Fellow;postsynaptic;Postsynaptic Membrane;presynaptic;Process;Property;protein complex;protein function;protein purification;Proteins;receptor;receptor function;recruit;Regulation;Research;Research Personnel;Research Project Grants;response;Role;scaffold;Schizophrenia;Serine;Shapes;Signal Transduction;Signaling Protein;single-molecule FRET;Site;skills;Structure;Synapses;Synaptic Cleft;Synaptic Membranes;Synaptic Receptors;Techniques;Technology;temporal measurement;Testing;Training;Work

PROJECT_TITLE: Synaptic Organization and Modulation of Kainate Receptors: Investigating the Structure, Dynamics, and Function in the Context of Trans-Synaptic Junctions


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: FENG, CHANGJIAN  (contact)

PROJECT_TERMS: Address;advanced analytics;Analytical Chemistry;analytical method;assay development;Binding;Biological;Biological Assay;catalyst;Chemistry;Collaborations;Complex;Computers and Advanced Instrumentation;Consultations;Core Facility;cost effective;Data Analyses;Dedications;design;detection method;Development;Discipline;Disease;Educational workshop;Effectiveness;Ensure;environmental agent;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Risk Factor;Environmental Science;Equipment;experience;Exposure to;Faculty;Feasibility Studies;Focus Groups;Funding;Genomics;Goals;Growth;health science research;Human Resources;Individual;innovation;Institution;instrumentation;Interdisciplinary Study;Investigation;Investments;Knowledge;Laboratories;Laboratory Research;Mass Spectrum Analysis;Measurement;Measures;member;Metal exposure;Metals;method development;Methodology;Methods;Mining;Modernization;Molecular Analysis;multidisciplinary;National Institute of Environmental Health Sciences;New Mexico;novel;operation;Outcome;outreach;Oxidative Stress;Persons;Population Study;Price;programs;Property;protocol development;Research;Research Design;research facility;Research Infrastructure;Research Personnel;Research Support;Resources;response;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Services;Students;synergism;Technical Expertise;Technology;Testing;Time;tool;Trace metal;Training;Training and Education;training opportunity;United States National Institutes of Health;Universities;validation studies;Work;Xenobiotics

PROJECT_TITLE: BioAnalytical Chemistry Core


NIH_SPENDING_CATS: Biotechnology;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: LUO, LI  (contact)

PROJECT_TERMS: Accounting;Air Pollutants;analytical method;Basic Science;Bayesian Method;Bioinformatics;bioinformatics pipeline;Bioinformatics Shared Resource;bioinformatics tool;Biometry;Biostatistical Methods;cancer genomics;Cardiovascular Diseases;Characteristics;Chemistry;citizen science;Clinical Research;Collaborations;Communication;Communities;Community Health;Complex;Complex Analysis;complex data;Complex Mixtures;Comprehensive Cancer Center;Data;Data Analyses;Data Analytics;Data Collection;data hub;data infrastructure;data management;Data Science;Data Science Core;Data Security;Data Set;Databases;design;Development;dietary;Dimensions;Disease;Dose;Education;Educational process of instructing;Educational workshop;Ensure;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Science;epidemiology study;Etiology;experience;exposure pathway;Faculty;FAIR principles;Funding;Generations;Genetic;Genomics;Geographic Information Systems;Health;high dimensionality;improved;Infectious Agent;Infrastructure;insight;Interdisciplinary Study;Intervention;Knowledge;large datasets;large scale data;Lead;lectures;Life Cycle Stages;Malignant Neoplasms;Manuscripts;member;metabolomics;Metal exposure;method development;Methodology;Methods;microbiome research;Modeling;Modernization;Monitor;multidimensional data;multidisciplinary;New Mexico;novel;Nutrient;Outcome;Pathway interactions;Physical activity;Policy Making;population based;Population Study;Positioning Attribute;Practice Management;Prevention strategy;Process;programs;Protocols documentation;Publishing;Quality Control;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;response;Risk Assessment;Risk Factors;Role;Sample Size;Science;Scientist;Services;statistical and machine learning;Statistical Data Interpretation;Surveys;Techniques;Testing;tool;Training;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Visualization software;Work

PROJECT_TITLE: Biostatistics and Data Science Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This study intends to use a new tonsil organoid platform to study molecular mechanisms regulating the human adaptive immune response to influenza. We will investigate how host factors and antigen factors regulate the magnitude and breadth of the influenza-specific antibody response in lymphoid tissues. This research will combine two novel technologies, immune organoids, and a high throughput antibody-detecting protein array, to elucidate the mechanisms of antibody affinity maturation and breadth in a fully human system.

PI_NAMEs: WAGAR, LISA  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adjuvant;Affect;Age;age related;Antibodies;Antibody Affinity;antibody detection;Antibody Diversity;Antibody Response;Antigens;Area;B-Lymphocytes;Blood;Blood specimen;CD4 Positive T Lymphocytes;Cell Communication;Cell Differentiation process;Cell Maintenance;Cells;Childhood;Clinical;cross reactivity;Data;design;Disparate;early childhood;Emerging Communicable Diseases;experimental study;Female;Frequencies;Future;Goals;Helper-Inducer T-Lymphocyte;Human;human model;Hypertrophy;Immune;Immune response;Immunity;Immunology;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Influenza;influenza infection;influenza virus strain;influenza virus vaccine;insight;Integration Host Factors;Investigation;Kinetics;Knowledge;Life;Lymphoid Tissue;male;Mediating;Medicine;Modality;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Mutation;Nature;neutralizing antibody;new technology;novel;novel vaccines;Obstructive Sleep Apnea;Organoids;pandemic potential;Participant;Patients;peripheral blood;Phenotype;Plasma;Population;Productivity;Protein Array;rational design;Recording of previous events;recruit;Research;response;Role;Seasons;Serology;sex;Signal Pathway;Signal Transduction;Structure of germinal center of lymph node;System;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Thromboplastin;Tissues;Tonsil;Tonsillectomy;universal influenza vaccine;Vaccination;vaccination strategy;Vaccine Design;vaccine development;vaccine trial;Vaccines;Variant;Virus

PROJECT_TITLE: Investigating protective adaptive immune responses to influenza antigens using human tonsil organoids

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Clinical Research;Rural Health;Social Determinants of Health

PI_NAMEs: GINOSSAR, TAMAR  (contact)

PROJECT_TERMS: Acceleration;Address;Advocacy;Air;Area;Beauty;Belief;Collaborations;Communication;Communities;community academic partnership;community engaged research;community engagement;community partnership;community research;Cultural Diversity;design;digital media;Disparate;Educational workshop;Enrollment;Ensure;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Science;Event;evidence base;experience;Exposure to;Faculty;Focus Groups;Fostering;Gases;Goals;Health;health care availability;health literacy;health science research;hydraulic fracturing;implementation science;Information Dissemination;Infrastructure;Journalism;Knowledge;Language;Lead;literacy;member;Mexico;Mining;Minority;Modeling;multimodality;National Institute of Environmental Health Sciences;Native American community;New Mexico;Oils;outreach;Policy Maker;Positioning Attribute;Poverty;Prevention;Printed Media;Process;programs;Public Health;public health research;remediation;Research;Research Personnel;Research Project Grants;research to practice;Risk;Rural;Science;Secure;social media;Soil;Structure;Students;symposium;tool;Toxic Environmental Substances;Toxicology;Training;Translating;Translational Research;Translations;Trauma;Uranium;Visual;wasting;Water;Work

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: HUDSON, LAURIE G (contact)

PROJECT_TERMS: Address;Area;Award;base;behavioral and social science;career;career development;Categories;Characteristics;Clinical;Collaborations;Collection;Communication Research;Communities;community engagement;Complex;Core Facility;Data;design;Education;Ensure;Environmental Health;Environmental Science;Epidemiology;Evaluation;Extramural Activities;faculty support;Focus Groups;Fostering;Funding;Funding Mechanisms;Goals;Grant;improved;innovation;innovative technologies;Institution;Intellectual Property;interest;Methods;Mission;New Mexico;next generation;operation;Peer Review;Pilot Projects;Process;Program Development;programs;Publications;Research;Research Activity;Research Personnel;response;satisfaction;Science;Structure;success;synergism;Teacher Professional Development;Time;Toxicology;Training;translational potential;trend;Universities

PROJECT_TITLE: Pilot Project Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Pulmonary arterial hypertension (PAH) is a disease of progressive obstruction and loss of the lung vessels with a median survival of slightly better than 5 years despite current therapies, with mortality resulting typically from right heart failure. This program seeks to identify the mechanisms by which dysregulated signaling of BMP9, which regulates pulmonary vascular homeostasis, may contributes to the pathogenesis of PAH. Novel strategies that selectively activate signals downstream of BMP9 may reveal the mechanisms responsible for its diverse effects on vascular integrity, and could represent novel strategies for treating PAH.

PI_NAMEs: YU, PAUL B (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: ACVR1 gene;ACVR2B gene;ACVRL1 gene;Animal Model;Attenuated;Automobile Driving;Biology;Blood Vessels;BMPR2 gene;cell growth;Cell Physiology;cell type;Cells;Circulation;Clinical;Coculture Techniques;Complex;Cultured Cells;design;Development;Disease;Disparate;Endothelial Cells;Endothelium;experience;Family;functional status;Gene Expression;Genes;Genetic;Hereditary hemorrhagic telangiectasia;Heritability;Homeostasis;Human;improved;In Vitro;in vivo;in vivo Model;Investigational Therapies;Ligands;loss of function mutation;Lung;lung microvascular endothelial cells;Modeling;monolayer;mortality;Motility;non-genetic;novel;novel strategies;novel therapeutic intervention;Obstruction;Outcome;Pathogenesis;Pathway interactions;Permeability;pharmacologic;Phenotype;Physiological;portopulmonary hypertension;Process;programs;Progressive Disease;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Circulation;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary Vascular Resistance;receptor;Recombinants;recruit;Regulation;Research;right ventricular failure;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Smooth Muscle;Smooth Muscle Myocytes;Syndrome;System;Tachyphylaxis;Therapeutic;Vasodilator Agents

PROJECT_TITLE: Context-specific angiogenic signaling in the pulmonary vasculature

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: This proposal examines the neural underpinnings of how sensory information about space is processed by the insect brain to control navigation through the environment. Insects are vectors of human diseases and common agricultural pests, so understanding the neural mechanisms that control their navigation is highly relevant to global human health and wellbeing. Further, as spatial orientation is one of the cognitive functions that deteriorate early in Alzheimer’s disease, conserved neural circuit motifs identified in our studies may contribute to a better understanding of the underlying mechanisms.

PI_NAMEs: BARNEA, GILAD  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Sensorimotor Transformations for Controlling Heading Direction in the Insect Central Complex

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Cardiovascular disease (CVD) remains the primary cause of death worldwide despite availability of a substantial armamentarium to combat it. High LDL and low HDL are risk factors for CVD, hence, understanding their regulation could lead to the identification of novel targets useful for drug development. Here, we plan to elucidate the molecular mechanisms underlying how miR-541-3p decreases LDL and increases HDL. These studies should identify new proteins and mechanisms that may serve as potential targets to decrease the risk of CVD.

PI_NAMEs: HUSSAIN, M MAHMOOD (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 3' Untranslated Regions;Affect;Anti-Inflammatory Agents;Antiatherogenic;Antioxidants;Apolipoproteins;Apolipoproteins B;Applications Grants;Atherosclerosis;Binding Sites;Blood;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cells;Cholesterol;combat;Complex;drug development;Enhancers;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Goals;Hepatic;Hepatocyte;hepatoma cell;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;in vivo;Libraries;Lipids;Lipoproteins;Low-Density Lipoproteins;Messenger RNA;MicroRNAs;Molecular;mRNA Transcript Degradation;Mus;mutant;Mutate;new therapeutic target;novel;Orthologous Gene;Output;Pathway interactions;Physiological;Plasma;posttranscriptional;prevent;Primary carcinoma of the liver cells;Production;promoter;Property;protein expression;Proteins;Regulation;Reporting;Repression;RNA;Role;Site;Testing;transcription factor;Transcriptional Regulation;Untranslated RNA;Zinc Fingers

PROJECT_TITLE: Regulation of plasma LDL and HDL by microRNA-541-3p

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Neurodevelopmental disability associated with prematurity, which leads to life-long morbidity and substantial personal and societal costs, is increasingly correlated to cerebellar insult. This proposal uses inducible genetic manipulation of cerebellar neurotransmission to undertake a comprehensive examination of the role of cerebellar function as it relates to circuit formation, neural function and animal behavior. This proposal has the potential to uncover causative mechanisms underlying a significant and growing cohort of patients with neurodevelopmental disability and may guide both preventative measures and disease modifying circuit manipulations.

PI_NAMEs: GILL, JASON SINGH (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Ablation;Address;Affect;Affective;Age;analytical tool;Anatomy;Animal Behavior;Behavior;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Brain;Brain Injuries;burden of illness;career;Cell Physiology;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Childhood;Clinical;Cognitive;cohort;college;critical developmental period;critical period;Data;design;Development;Diagnosis;Disease;disorder prevention;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Etiology;experience;Experimental Designs;experimental study;Exposure to;Family;field study;Funding;Genetic;genetic manipulation;Genetic Models;genome editing;Grooming;Human;Image;Imaging Techniques;Immunohistochemistry;in vivo;Incidence;Inferior;Injury;innovation;insight;Instinct;Intervention;Leadership;LoxP-flanked allele;Marble;Mediating;Medicine;Mendelian disorder;Mentors;Mentorship;model organism;Modeling;Morbidity - disease rate;motor behavior;motor deficit;mouse development;mouse genetics;network dysfunction;neurodevelopment;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurologic;Neurologist;Neurons;Neurophysiology - biologic function;Neurosciences;neurotransmission;Nose;Nuclear;old mice;Olives - dietary;Outcome;Output;Pathogenesis;Pathology;Pathway Analysis;Patients;Pattern;Pediatric Hospitals;Pediatric Neurology;Personal Satisfaction;Physicians;Physiological;Population;postnatal;Pregnancy;premature;prevent;Prevention;preventive intervention;Preventive measure;Property;Public Health;Purkinje Cells;Research;research facility;Research Institute;response;Role;safety net;Scientist;Site;social;societal costs;Structure;support network;System;Techniques;Testing;Tetracyclines;Texas;Therapeutic;Third Pregnancy Trimester;Training;Transcriptional Activation;United States National Institutes of Health;vesicular GABA transporter;water maze;Work

PROJECT_TITLE: Unraveling the Dynamic Role of Purkinje Cell Neurotransmission in Neurodevelopment.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Digestive Diseases;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Malaria;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE We previously reported that type I interferon signaling induced in response to the asymptomatic liver stages of malaria parasite infection compromise protective adaptive immunity by inducing dysfunctional hepatic memory CD8 T cells. Using infection of the liver by malaria parasites as a model for hepatotropic infection, this application seeks to characterize malaria-induced hepatic CD8 T cell dysfunction to determine how hepatocyte-intrinsic type I interferon signaling reshapes hepatocyte transcriptomes and metabolomes to impair hepatic T cell immunity. Observations from this work will guide the development of highly efficacious liver directed anti-malaria vaccines.

PI_NAMEs: MINKAH, NANA KWAKU (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Ablation;adaptive immunity;amino acid metabolism;Animals;antagonist;Anti-malarials;Antigen Presentation;Antigens;Attenuated;Benign;Biological Assay;Biological Models;Bite;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Cessation of life;chronic infection;Clinical;Complex;Culicidae;cytokine;Cytoplasm;Data;Data Set;Deposition;Development;dietary;Environment;Equilibrium;Erythrocytes;exhaust;exhaustion;Exhibits;Focal Infection;Functional disorder;Gene Expression Profiling;Hepatic;Hepatocyte;Human;human subject;Immune;immune activation;Immune response;Immune signaling;Immune System Diseases;Immunity;Immunize;Immunologics;immunoregulation;Impairment;improved;in vivo;Individual;Infection;Innate Immune Response;Interferon Type I;IRF3 gene;Lipids;Liver;Liver diseases;liver function;liver infection;Malaria;malaria infection;Malaria Vaccines;Mediating;Memory;Metabolism;metabolome;metabolomics;microorganism antigen;Modeling;Molecular;Molecular Analysis;mouse model;multiple omics;Mus;novel;Nutrient;Nutrient availability;Parasites;Parasitic infection;pathogen;Pathway interactions;Phenocopy;Plasmodium;Plasmodium falciparum;Play;prevent;Primary carcinoma of the liver cells;programmed cell death protein 1;programs;Publishing;receptor;Reporting;response;Rodent;Role;Shapes;Signal Induction;Signal Transduction;Skin;Sporozoites;Supplementation;T cell response;T memory cell;T-Lymphocyte;Testing;Time;Tissues;transcription factor;transcriptome;transcriptomics;Transgenic Organisms;Travel;tumor;tumor microenvironment;tumor-immune system interactions;Up-Regulation;vaccine efficacy;Vaccines;Viral;Work

PROJECT_TITLE: Impairment of anti-Plasmodium T cell memory by type I Interferon Signaling


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Public Health relevant statement This project is to design, produce and conduct proof of concept experiments to test a novel therapeutic reagent that has the potential to rapidly activate immune defenses against many infectious diseases. The project builds on results from research on basic immunological mechanisms conducted over the past decade and on the combined expertise with protein engineering design and production.

PI_NAMEs: LAI, JONATHAN R.;LAUVAU, GREGOIRE STEPHANE (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: acute infection;antibody engineering;Antibody Response;Antigens;arm;Autophagocytosis;B-Lymphocytes;Bacteria;Binding;Biochemical;Biological Products;Biological Testing;Bispecific Antibodies;CCL3 gene;CCL4 gene;CCR1 gene;CCR5 gene;CD14 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cellular biology;chemokine;chemokine receptor;Chimeric Proteins;Clonal Expansion;Communicable Diseases;Containment;CXCL9 gene;cytokine;Cytolysis;Cytoprotection;design;Development;Dose;Engineering;engineering design;experimental study;Fc Receptor;FCGR3B gene;gamma-Chemokines;Goals;Growth;Hour;Human;Human Herpesvirus 2;Immune;Immune response;Immunologics;In Vitro;in vivo;Infection;Inflammatory;Interferon Type II;Ligands;Link;Listeria monocytogenes;Malaria;Mediating;Memory;microbicide;monocyte;monomer;mouse model;multiphoton imaging;Mus;neoplastic cell;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Parasites;pathogen;pathogenic microbe;Phagocytes;Plasmodium chabaudi;Play;Production;prophylactic;Protein Engineering;Proteins;Public Health;Reagent;receptor;Reporting;Research;response;Role;Science;Series;Signal Transduction;Site;Study models;T memory cell;T-Lymphocyte;Testing;Therapeutic;TNF gene;tumor;Vaccinated;Vaccines;XCL1 gene;XCR1 gene

PROJECT_TITLE: Developing a new bispecific antibody mimicking rapid antigen-specific memory CD8+ T cell-mediated protection


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE  As the number of older adults continues to rise, and the prevalence of individuals affected by neurodegenerative disease increases, understanding the interpersonal factors that contribute to caregivers’ health decline will become increasingly important. Identifying interpersonal mechanisms that promote or hinder caregivers’ health will point towards potentially modifiable factors that could reduce the collateral damage of neurodegenerative disease. Findings from the current research could facilitate the development of targeted and effective interventions to maintain the health of caregivers and the individuals for whom they care.

PI_NAMEs: BROWN, CASEY LEIGH (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acute;adverse outcome;Affect;Aging;Alzheimer's Disease;archived data;Area;Atrophic;Behavior;Behavioral;behavioral variant frontotemporal dementia;Biological Markers;Blood;Brain region;California;care recipients;career;Caregiver well-being;Caregivers;caregiving;Caring;Characteristics;Cognitive;Collection;comparison control;Conflict (Psychology);Critical Pathways;Cues;Data Collection;Development;Disease;effective intervention;emotion regulation;Emotional;emotional stimulus;Emotions;Empathy;Environment;Equation;experience;Face;flexibility;Functional impairment;Goals;Growth;Health;Health Psychology;Impairment;indexing;Individual;Laboratories;late life;Lead;Light;Link;loved ones;Measurement;Medial;Memory;Mental Health;Mentorship;Modeling;negative affect;neural;Neurodegenerative Disorders;neuroimaging;older adult;Outcome;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;positive emotional state;Prevalence;Process;Psychology;Reporting;Research;respiratory;response;San Francisco;showing emotion;Sinus Arrhythmia;skills;Social Network;Social support;Spouse Caregiver;Statistical Models;Stress;stressor;Techniques;Technology;theories;Time;Training;Universities;Visual attention;visual tracking

PROJECT_TITLE: Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Clinical Research;Infectious Diseases;Nanotechnology

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative: The sudden and profound physiological changes in critically ill patients cause dramatic variations of concentrations of antibiotics that we actually deliver, away from those that are effective and, often, towards those that are harmful. In theory, this challenge can be addressed by high-frequency therapeutic drug monitoring, which would allow us to adjust delivered doses of antibiotics as these concentrations change – yet, in practice, there are no clinically validated analytical methods that can perform suitably rapid and cost-effective quantification of drugs. In this project, we systematically develop modular components, which, individually or combined, will enable precise and accurate measurements of antibiotic concentrations in real-time at the bedside.

PI_NAMEs: CREMERS, SERGE ;LIN, QIAO ;MOHAN, SUMIT ;STOJANOVIC, MILAN N (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TITLE: Towards rapid measurement of antibiotics in critical care setting

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We will develop a fully implanted, wirelessly powered and telemetered recording and stimulation system. This system will restore sensorimotor function by interfacing with motor and sensory cortex of patients with high spinal cord injury, and be the first fully mobile brain machine interface for increasing the independence of people with severe motor impairments.

PI_NAMEs: TENORE, FRANCESCO V (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Action Research;Activities of Daily Living;Affect;Amendment;Animal Model;Area;arm;Artificial Arm;Brain;brain machine interface;Chronic;Clinical Research;Clinical Trials;Cochlear Implants;Communication;communication device;Data;Device Safety;Devices;Environment;Feasibility Studies;Feedback;first-in-human;Goals;grasp;Hand;Histologic;Home;Home environment;Human;Implant;implantation;improved;Individual;Institution;integrated circuit;Interview;Laboratories;Limb structure;Microelectrodes;microstimulation;Motor;motor control;Motor Cortex;motor impairment;neural;neural stimulation;Neurodegenerative Disorders;Neuromuscular Diseases;neuroprosthesis;neuroregulation;novel;Participant;Patients;Perception;Performance;Periodicals;Persons;portability;preclinical efficacy;preclinical safety;Preclinical Testing;Prosthesis;Protocols documentation;Quadriplegia;Reaction;Reporting;Research Personnel;research study;restoration;Robotics;Safety;safety study;sensor;Sensorimotor functions;Sensory;sensory cortex;sensory feedback;sheep model;Somatosensory Cortex;Spinal cord injury;Standardization;subcutaneous;System;Tactile;Task Performances;Technology;telemetering;Testing;Time;Tissue Viability;translational study;Universities;Upper Extremity;Validation;wireless;wireless implant

PROJECT_TITLE: Wireless Implantable COrtical Neuroprosthetic System (W-ICONS)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Endocrine Disruptors;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This research will exploit novel features of the Atlantic killifish vertebrate model system to elucidate gene- environment interactions that contribute to chemical-induced congenital heart disease. Natural selection across dozens of generations has created wild killifish populations that diverge dramatically in sensitivity to chemical effects, and our prior results have provided a catalog of genetic variation among populations that underlies these differences. We will leverage this unique natural experiment to reveal the genes and pathways that contribute to chemical-induced congenital heart disease (CHD), a common human malformation associated with environmental exposures.

PI_NAMEs: HAHN, MARK E;WHITEHEAD, JOHN ANDREW (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: adverse outcome;Affect;Animals;Aromatic Polycyclic Hydrocarbons;Biological Models;Breeding;Candidate Disease Gene;candidate selection;Cardiovascular Diseases;Cardiovascular system;Catalogs;chemical association;Chemicals;Complex;Congenital Abnormality;congenital heart abnormality;CRISPR/Cas technology;Data;Development;Disease;Disease Outcome;disease phenotype;Dose;Embryo;Environment;environmental chemical;Environmental Exposure;Environmental Risk Factor;Etiology;Evaluation;Event;Exhibits;experimental study;Exposure to;Family;fitness;fluoranthene;Frequencies;Fundulus heteroclitus;gene environment interaction;Gene Expression Profile;Generations;Genes;Genetic;genetic approach;genetic association;genetic risk factor;genetic testing;Genetic Variation;Genome;genome editing;Genome Scan;genome-wide;genomic data;Genomics;Genotype;Heritability;Human;human disease;in vivo;Individual Differences;insight;Killifishes;malformation;Maps;Mediating;Modeling;Molecular;Natural experiment;Natural Selections;novel;Outcome;Pathway interactions;Pattern;phenanthrene;Phenotype;pollutant;Pollution;Polychlorinated Biphenyls;Population;population based;Predisposition;Quantitative Genetics;Quantitative Trait Loci;rare variant;Research;Resistance;response;Role;segregation;Severity of illness;System;Testing;transcriptomics;Urbanization;Variant;Vertebrates;Zebrafish

PROJECT_TITLE: Gene-by-environment interactions that affect exposure-mediated congenital heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(04)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Building on our recent discovery that antimalarial drugs display potent therapeutic and adjunct therapeutic efficacy against Mycobacterium abscessus infections, this research project proposes to thoroughly investigate the mechanisms underlying the therapeutic benefits of these drugs and to extend their use to the treatment of Mycobacterium avium infections. Success in this approach could be a short route to the clinic.

PI_NAMEs: JACKSON, MARY  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Animal Model;Anti-malarials;Antibiotics;Antimycobacterial Agents;Applications Grants;Bacteria;bactericide;Biological Assay;Bronchiectasis;C3HeB/FeJ Mouse;Carbon Monoxide;Cell model;Cell Respiration;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Complex;Cystic Fibrosis;Development;drug development;drug efficacy;Drug Modelings;Drug Targeting;Drug Tolerance;effective therapy;efficacy testing;Equilibrium;Exposure to;extracellular;Genes;Genetic;Genotype;Granuloma;Granulomatous;Heme;Human;Hypoxia;Immune;Immunology;improved;In Vitro;in vivo;Individual;Infection;inhibitor;Lesion;Lung;lung hypoxia;Lung infections;lung lesion;Metabolism;Microbial Biofilms;microorganism;mouse model;Mus;mutant;Mycobacterium abscessus;Mycobacterium avium Complex;Mycobacterium avium-intracellulare Infection;Mycobacterium tuberculosis;Necrosis;Nitric Oxide;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;Oxidation-Reduction;pathogen;Peroxides;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Phenotype;Phosphotransferases;Physiology;Play;Predisposition;Prevalence;Process;Regimen;Regulon;Relapse;Research Project Grants;Respiration;response;Route;SCID Mice;sensor;standard of care;Stress;Structure;success;Testing;Therapeutic;Toxic effect;Treatment Efficacy;Treatment Failure;Treatment outcome;tuberculosis treatment;Variant

PROJECT_TITLE: Repurposing antimalarials for the treatment of NTM infections

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Each of us has the potential to respond uniquely to a drug based on our genetics. Not understanding how a drug works in diverse groups of people can lead to serious inequities in health and wellbeing. Our preliminary data provides evidence that a drug called ulipristal acetate may not work as well for people with an active form of a certain gene (CYP3A5); the active form is more prevalent in Black individuals. We have designed this project to determine the impact of this gene and others on ulipristal acetate metabolism as this has important implications for its ability to prevent pregnancy.

PI_NAMEs: EDELMAN, ALISON B (contact);HENNEBOLD, JON D

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Acetates;aged;Alleles;Animal Model;Animals;Asthma;Binding;Biological;Black Populations;Black race;Blood;Blood specimen;Body mass index;Cardiovascular Diseases;Categories;Cell Physiology;Characteristics;clinically relevant;Communicable Diseases;Contraceptive Agents;Contraceptive Availability;contraceptive efficacy;Contraceptive methods;Contraceptive Usage;CYP3A4 gene;Cytochrome a;Cytochrome P450;Data;design;Development;Disparity;Dose;drug efficacy;Drug Kinetics;drug metabolism;Economics;emergency contraception;Enrollment;enzyme activity;Enzymes;Estradiol;experience;Failure;Follicular Fluid;Frequencies;Gene Expression;Gene Frequency;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genomics;Genotype;Goals;granulosa cell;Half-Life;Health;health care availability;health disparity;health inequalities;Human;human subject;Hypertension;Individual;inhibitor;Intervention;intraovarian;Kinetics;Knowledge;Liver;Luteinizing Hormone;Macaca mulatta;Malignant Neoplasms;Medical;Metabolism;Methods;Modeling;Monitor;nonhuman primate;novel;Obesity;Oocytes;Oral;Other Genetics;Outcome;Ovarian;Ovarian Follicle;Ovary;Ovulation;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Phenotype;Population;Pregnancy;prevent;primary endpoint;Primates;Process;Progesterone;Publishing;Race;racial discrimination;racial disparity;receptor;recruit;Regression Analysis;Reporting;reproductive;Research;response;Risk;Rupture;Sampling;Serum;Sex Discrimination;Site;social determinants;social health determinants;Stimulus;Study Subject;Testing;Therapeutic;Time;Transvaginal Ultrasound;unintended pregnancy;United States;Variant;Woman;women of color;Work

PROJECT_TITLE: Disparities in emergency contraceptive metabolism dictate efficacy


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_CITY: KALAMAZOO

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

ORG_STATE: MI

PHR: Project Narrative B-cells play various critical roles in protecting against microbial invasions by secreting antibodies and cytokines, and dysfunction of B-cells causes immunodeficiency, autoimmunity, or leukemia/lymphomas. Emerging evidence has shown that not only innate-immune B-cells but also a portion of adaptive immune B cells originate from fetal progenitors, independently of hematopoietic stem cells. The objective of this project is to develop a landscape of the developmental process of all B cell subsets from fetus to adult, exploring the precise origins and functions, thus, contributing to filling the knowledge gap in B-cell biology.

PI_NAMEs: HOLODICK, NICHOL ELIZABETH;YOSHIMOTO, MOMOKO  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;adaptive immunity;Address;Adult;Animals;Antibodies;Aorta;Autoimmune;Autoimmunity;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bar Codes;base;Biological;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Cell Lineage;Cell secretion;Cells;Cellular biology;Cessation of life;Complication;cytokine;Data;Development;Developmental Process;Disease;Embryo;embryo cell;Embryonic Development;Endothelial Cells;endothelial stem cell;fetal;Fetal Liver;fetal stem cell;Fetus;Frequencies;Functional disorder;Goals;Gonadal structure;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hemogenic endothelium;Immune;Immune system;Immune System Diseases;Immunity;immunodeficiency;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin M;Immunology;improved;In Vitro;in vivo;Infection;Intestines;Invaded;Knowledge;Label;leukemia/lymphoma;Life;Lymphocyte;Lymphocyte Depletion;Lymphoid;Lymphoid Cell;lymphoid organ;Lymphopoiesis;Maps;mast cell;Mature B-Lymphocyte;Mesonephric structure;microbial;Microglia;Modeling;mouse model;Mus;Neonatal;old mice;Pathology;Pathway interactions;perinatal period;Peritoneal;Phase;Play;Population;postnatal;Pregnancy;Production;progenitor;Recovery;Reporting;Research;response;Role;segregation;Sorting;Spleen;stem cells;Streptococcus pneumoniae;Technology;theories;Therapeutic;Tissues;Transplant Recipients;Transplantation;transplantation therapy;Trees;Vaccination;Visualization;Yolk Sac;γδ T cells

PROJECT_TITLE: The developmental pathway of fetal-derived B cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: LAGOS

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: NIGERIAN INSTITUTE OF MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related marker of blood cancer and cardiovascular diseases. Early and pre-disease detection of rare somatic mutations associated with CHIP in clinically healthy normal-aging Nigerians is much needed as they could offer important prediction of the risk of developing hematological malignancies and provide information on potential targets of therapeutic interventions. This project will also enable me to acquire fundamental skills in error-corrected sequencing, variant analysis and data management critical for my establishment as an independent Africa-based medical geneticist.

PI_NAMEs: OYEBOLA, KOLAPO  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adopted;Africa;African;African American population;African ancestry;Age;age related;age related biomarkers;American;Architecture;Award;Behavioral;Bioinformatics;Biological Assay;Blood Cells;Blood specimen;cancer genetics;Cardiovascular Diseases;career;career development;Caucasians;Cell Lineage;chemokine;Chronic;Clinical;Clonal Expansion;cohort;comorbidity;Computer Analysis;cytokine;Data;Data Analyses;data management;Data Science;data visualization;Databases;Detection;Diagnosis;Disease;DNA Library;drug development;Drug Targeting;follow-up;Frequencies;Gene Frequency;Genes;Genetic;genetic analysis;genetic variant;genome database;genome sequencing;genome wide association study;Genotype;Germ Lines;Goals;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Individual;Inflammation;Inflammatory;inflammatory marker;Intercept;interest;Laboratories;Leadership;leukemia;magnetic beads;Malignant - descriptor;Malignant Neoplasms;Medical;Medical Research;Mentors;Minor;Minority;mortality;Mutate;Mutation;Myeloid Leukemia;Myeloproliferative disease;National Heart, Lung, and Blood Institute;Nigeria;Nigerian;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Outcome;Patients;peripheral blood;Population;Population Genetics;post-doctoral training;Preparation;pressure;Prevalence;rare variant;Research;Research Activity;Research Personnel;Risk;Risk Factors;risk prediction;Signal Transduction;skill acquisition;skills;Somatic Mutation;study population;targeted sequencing;targeted treatment;Technology;Testing;Therapeutic Intervention;Time;Time trend;Training;Training Activity;Trans-Omics for Precision Medicine;United States National Institutes of Health;Variant;variant detection;volunteer;Whole Blood;whole genome

PROJECT_TITLE: Prevalence and temporal dynamics of clonal mutations associated with the risk of hematological cancer in a cohort of clinically healthy Nigerians

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

PHR: Measles causes a severe transient immunosuppression in healthy individual and severe complications in immunocompromised people. Recent U.S. outbreaks shows that 1 of every 600 measles infections in normal infants may also develop fatal measles encephalitis, underscoring the urgency of developing specific treatment for measles infection for the general population as well as for immune compromised individuals. Recent advances in our paramyxovirus research are ready to be applied to developing antiviral peptides to protect the individual and to halt measles host-to-host transmission.

PI_NAMEs: POROTTO, MATTEO  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acute;airway epithelium;Amnesia;Animal Model;Animals;Anti-viral Agents;Area;Attenuated;Biodistribution;Canine Distemper Virus;Cell membrane;Cells;Cellular Immunity;Central Nervous System Infections;Chemical Engineering;Child;Chimeric Proteins;Clinical;Communicable Diseases;Complex;conformational conversion;Cytoplasm;Data;design;dimer;Disease;Disease Outbreaks;efficacy evaluation;efficacy study;emerging virus;Encephalitis;Engineering;Epithelial Cells;Ethics;Ferrets;Fetus;General Population;Genome;Grant;Hemagglutinin;Hospitalization;human disease;Hydrophobicity;Immune;Immune system;Immunocompromised Host;immunogenicity;Immunosuppression;Impairment;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;Infant;Infection;Infection prevention;inhibitor;Interruption;Intranasal Administration;Kinetics;Lipids;low and middle-income countries;Lung;Lymphoid Cell;Measles;Measles Vaccine;Measles virus;Measures;Mediating;Medical;Medical center;Membrane;Membrane Glycoproteins;Modeling;Molecular Conformation;Morbidity - disease rate;Morbillivirus;Morbillivirus Infections;mortality;Mothers;Myeloid Cells;N-terminal;nanoparticle;National Institute of Allergy and Infectious Disease;nectin;Neurologic;nonhuman primate;Nucleoproteins;outbreak control;Paramyxovirus;Pathogenesis;Peptides;Periodicals;Permeability;Persons;Play;Pneumonia;pre-exposure prophylaxis;preclinical development;Predisposition;Pregnant Women;prevent;Primates;Property;Protein Engineering;Proteins;receptor;Recombinants;Reporter;Reporting;Research;Ribonucleoproteins;Risk;RNA;RNA-Directed RNA Polymerase;Rodent;Role;self assembly;Site;SLAM protein;Testing;Toxic effect;Translating;transmission process;United States;Vaccinated;Vaccination;Vaccines;Vertical Transmission;Viral;Viral Physiology;viral transmission;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Design of fusion inhibitors to block measles host-to-host infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Traumatic Head and Spine Injury

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The interactions between neural stem cells (NSC) and the extrinsic microenvironment are poorly understood. The objective of this proposal is to address this gap in knowledge, enabling both optimization of therapeutic donor hNSC transplantation, as well as new insights into the in vivo consequence of signaling/transcriptional networks for hNSC localization and fate after SC. The long term impact of this work will be to elucidate novel mechanisms and roles of immune-NSC signaling.

PI_NAMEs: ANDERSON, AILEEN J (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Address;Antibodies;Architecture;Automobile Driving;Blood;CD44 gene;cell behavior;Cell Line;Cell Nucleus;Cell Transplantation;Cells;Cellular Morphology;ChIP-seq;Chromatin;Chronic;Cicatrix;cofactor;Complement 1q;Complex;Cytometry;Data;Demyelinations;Dependence;Detection;differentiation in vitro;embryonic stem cell;Engraftment;Epigenetic Process;Functional impairment;Gene Activation;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;Hematopoietic stem cells;Heterochromatin;Human;Hyaluronic Acid;Image;Immune;Immune response;In Vitro;in vivo;in vivo Model;Infiltration;Inflammatory;Inflammatory Response;Injury;injury and repair;insight;Knock-out;Knockout Mice;Knowledge;Lesion;Ligands;Link;Locomotor Recovery;Macrophage;Mediator;Medical;Mesenchymal Stem Cells;Methods;Microglia;migration;MMP9 gene;Modeling;Modification;Multiple Sclerosis;Mus;Natural regeneration;nerve stem cell;novel;osteopontin;Phase;Play;progenitor;Proliferating;Promoter Regions;Proteins;Publishing;receptor;receptor-mediated signaling;remyelination;repaired;Resolution;response;Rodent;Role;secretase;Serum Proteins;Signal Induction;Signal Transduction;spatiotemporal;Spinal Cord;Spinal cord injury;stem cell fate;stem cell genes;stem cell migration;stem cell niche;Stem cell transplant;Testing;Therapeutic;Tissue Preservation;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transmembrane Domain;Transplantation;Work

PROJECT_TITLE: Investigating the role of CD44 and immune-neuro signaling mechanisms in neural stem cell responses after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Relevance Kidney diseases are associated with significant comorbidities and mortalities and affect close to a third of the US population, yet their pathophysiology remains incompletely understood. Macula densa cells play pivotal roles in the maintenance of the normal structure and function of the healthy glomerulus and also in the development of glomerular injury in kidney diseases, yet their primary pathogenic role has been largely overlooked. We propose to study the role of macula densa cells and their neuron-like function in the normal and diseased kidney, and to develop new therapeutic approaches for glomerular kidney diseases.

PI_NAMEs: PETI-PETERDI, JANOS  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Adriamycin PFS;Affect;Alzheimer's disease risk;Amyloid;arginine methyl ester;Axon;Bioinformatics;Brain;brain tissue;Calcium;Cell Line;Cell model;Cell Physiology;cell type;Cells;Chemicals;Chronic;Chronic Kidney Failure;Clozapine;comorbidity;designer receptors exclusively activated by designer drugs;Development;diabetic;dietary salt;Disease;Environment;Epithelial Cells;Feedback;Focal and Segmental Glomerulosclerosis;Functional disorder;Future;Genes;Grant;Growth Factor Receptors;hemodynamics;Homeostasis;Hormones;improved;In Vitro;in vivo;Injury;innovation;insight;Insulin-Dependent Diabetes Mellitus;Interoception;Juxtaglomerular Apparatus;Kidney;kidney cell;Kidney Diseases;Knockout Mice;Macula densa;Maintenance;meter;microscopic imaging;Modeling;Molecular;mortality;mouse model;multiphoton imaging;multiphoton microscopy;Mus;Nephrons;Nerve;Nerve Degeneration;Neurons;Neurosecretory Systems;Neurotransmitters;NGFR gene;NGFR Protein;non-diabetic;novel;novel therapeutic intervention;optogenetics;Oxides;Pacemakers;Paint;Pathogenesis;Pathogenicity;Peptides;Perfusion;pharmacologic;Phenotype;Photons;Physiological;Physiological Adaptation;Play;Population;Process;renal epithelium;Renin;repaired;response;risk variant;Role;salt intake;Signal Transduction;Specificity;Streptozocin;Streptozocin Diabetes;Structure;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;tool;transcriptome;Transgenic Mice;Work

PROJECT_TITLE: Multiphoton imaging of the juxtaglomerular apparatus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Neurodegenerative;Palliative Care;Patient Safety;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The COVID-19 pandemic has exacerbated the burdens of families living with dementia, whose needs are not met by traditional health care models. This project will accelerate research on the effectiveness and implementation strategies of a remotely-delivered collaborative care model for dementia, the Care Ecosystem, in 6 healthcare systems. During this unprecedented time of heightened strain on family caregivers, health care providers and health systems, will identify the effects of the Care Ecosystem on outcomes important to patients, caregivers, healthcare providers, and healthcare systems, and we will identify strategies that will facilitate successful implementation and sustainment.

PI_NAMEs: POSSIN, KATHERINE LAUREL (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;advanced dementia;advanced disease;barrier to care;Bed Occupancy;Behavior;Behavioral Symptoms;Black race;Caregiver Burden;caregiver depression;Caregiver support;Caregiver well-being;Caregivers;Caring;Clinical;cohort;collaborative care;Communication;Communities;Community Health;comparison group;Complex;cost;COVID-19;COVID-19 pandemic;Data;Dementia;dementia burden;dementia care;Dementia caregivers;design;Development;Discipline of Nursing;Ecosystem;Effectiveness;effectiveness evaluation;effectiveness study;Electronic Health Record;Emergency department visit;Emergency medical service;Enrollment;Environment;ethnic minority population;Evaluation;evidence base;experience;Family;family burden;Family Caregiver;Fee-for-Service Plans;Fright;Future;Geography;Goals;health care model;Health Personnel;Health system;Healthcare;Healthcare Systems;high risk;Home;hospital readmission;Hospitalization;implementation barriers;implementation facilitators;implementation science;implementation strategy;implementation/effectiveness;improved;improved outcome;Infection;Internet;Intervention;Interview;Latinx;Licensing;Locales;Medical;Medicare claim;Mental Depression;Methods;Modeling;Monitor;Outcome;pandemic disease;Participant;patient population;Patients;person centered;Persons;Pharmaceutical Preparations;Pharmacy facility;Population Heterogeneity;pragmatic trial;Primary Care;primary outcome;programs;Protocols documentation;Provider;Public Health;Quality of Care;Quality of life;racial minority population;randomized, clinical trials;remote delivery;remote health care;Research;Resources;response;Risk;Risk Adjustment;Rural;Sampling;satisfaction;Science;secondary outcome;Services;Site;Social isolation;Social Work;Specialist;Standardization;Structure;Supportive care;Surveys;Technology;Telephone;Time;Training;Underrepresented Populations;Underserved Population;Vulnerable Populations;Work

PROJECT_TITLE: The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Microbiome

ORG_CITY: CLEVELAND

ORG_DEPT: DENTISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE - PUBLIC RELEVANCE STATEMENT Systemic inﬂammation and mortality in people living with HIV (PLWH) are associated with mucosal immune dysfunction and persistent viral reservoirs in the mucosa and lymphoid tissues. Our proposal determines the underlying mechanism of immunological dysfunction in the mouth and will reveal new directions to address oral disease and systemic inﬂammation n PLWH.

PI_NAMEs: PANDIYAN, PUSHPA  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Age;Aging;Amphiregulin;antiretroviral therapy;Attenuated;beta diversity;Bioinformatics;Biopsy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical;Clinical Immunology;clinical practice;co-infection;comorbidity;Data;dectin 1;Dentistry;Diagnosis;dysbiosis;Feedback;Flow Cytometry;FOXP3 gene;Functional disorder;Fungal DNA;Gingiva;Goals;gut microbiome;Health;HIV;HIV Infections;Human;Human Papillomavirus;Hypoxia;Immune;immune health;Immune response;Immune system;Immune System Diseases;immunoregulation;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;insight;Interleukin-1 beta;Intervention;IRAK1 gene;Ligands;Ligation;Link;Literature;Lymphoid;Lymphoid Tissue;Measurement;Mediating;Metabolic;metabolome;microbiome;microbiome analysis;microbiome composition;microbiota;mortality;Mouth Diseases;Mucosal Immunity;Mucous Membrane;multidisciplinary;novel;Oral;Oral cavity;oral fungal;oral immunity;Oral Medicine;oral microbiome;Oral mucous membrane structure;oral tissue;Organoids;Pathway interactions;Persons;programmed cell death protein 1;programs;Proteins;Proto-Oncogene Proteins c-akt;receptor;Regulatory T-Lymphocyte;Residual state;Role;Saliva;Salivary;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Smoking;SYK gene;systemic inflammatory response;T-Lymphocyte;Testing;Tissues;TLR2 gene;Tonsil;transcriptomics;Up-Regulation;Viral reservoir;Work

PROJECT_TITLE: Amphiregulin-Immunometabolism axis in oral immunity and inflammation during HIV infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: We plan to use Wnt/planar cell polarity signaling as a tool to address unsolved fundamental questions in growth cone guidance and understand its expanded role in adult axon regeneration.

PI_NAMEs: ZOU, YIMIN  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Address;Adult;Affect;Anatomy;Animals;Anterior;Apical;Axon;axon growth;axon guidance;axon regeneration;Binding Proteins;Biological;Caenorhabditis elegans;Cells;Chick;conditioning;Corticospinal Tracts;CRISPR/Cas technology;Cues;Dendrites;Development;Dorsal;Drosophila genus;Endocytosis;Family;Floor;FMR1 gene;functional restoration;Funding;Genes;Genetic;Glutamates;glycosylation;Growth;Growth Cones;inhibitor;injured;Invertebrates;Knock-in Mouse;Knowledge;Label;Lead;Length;Lesion;Location;LRRK2 gene;Manuscripts;Maps;Mediating;Modeling;morphogens;Motor;nervous system development;neural circuit;Neurodegenerative Disorders;PARK8 gene;Parkinson Disease;Pathway interactions;Phosphorylation;Phosphotransferases;planar cell polarity;polymerization;Polymers;postsynaptic neurons;Preparation;presynaptic neurons;Publications;Recovery;Recovery of Function;recruit;repaired;response;Rodent;Role;Sensory;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;Spinal Cord;Spinal cord injury;Spinal Ganglia;Synapses;synaptogenesis;System;Testing;Time;tool;Traumatic injury;Visual System;WNT Signaling Pathway;Work;Yam - dietary;Zebrafish

PROJECT_TITLE: Characterizing Wnt Signaling Pathways in Axon Guidance


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: NARRATIVE Rheumatic diseases constitute a major health care problem; they are among the most common and costly causes of chronic disease and long term disability. These diseases are also complex and difficult to treat. This program will improve health care by training researchers who will translate technical advances into earlier diagnosis and more effective therapies.

PI_NAMEs: CROFFORD, LESLIE J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Rheumatism;Training

PROJECT_TITLE: Interdisciplinary Training in Rheumatic Diseases


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Emergency Care;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TUCSON

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because pulmonary embolism is one of the leading causes of death in hospitalized patients, and its rapid diagnosis is crucial to guide emergency treatment and decrease economic burden. Therefore, our project will develop an innovative machine learning algorithm that can transform the care of patients with pulmonary embolism by enabling non-experts to use echocardiography at the patient’s bedside to detect life-threatening pulmonary embolism, direct emergency therapy, and improve survival. Our proposal fits the NIBIB’s overall mission to improve healthcare through innovative engineering and, more specifically, to develop transformative unsupervised/semi- supervised machine learning technologies to enhance analysis of complex medical images and data for diagnosing and treating a wide range of diseases and health conditions.

PI_NAMEs: ADHIKARI, SRIKAR REDDY (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acute;acute care;Adoption;Algorithms;Anatomy;Artificial Intelligence;artificial intelligence algorithm;cardiology service;Cardiopulmonary;Cause of Death;Cessation of life;Clinical;Clinical assessments;clinical decision support;clinical practice;clinical translation;Complex;Computer software;Data;Death Rate;deep learning;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Disease;Early Diagnosis;Early identification;Echocardiography;Economic Burden;Emergency treatment;Engineering;Environment;Evaluation;Goals;Health;Health Care Costs;health care settings;Health Personnel;Healthcare;hemodynamics;Hospitalization;Hospitals;Hour;Image;Image Analysis;improved;innovation;Learning;Life;Machine Learning;machine learning algorithm;Medical Imaging;Mission;Morbidity - disease rate;mortality;Myocardial dysfunction;National Institute of Biomedical Imaging and Bioengineering;Neural Network Simulation;noninvasive diagnosis;Outcome;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Persons;Physicians;point of care;prototype;Psychological reinforcement;Public Health;Pulmonary Embolism;Quality of life;rapid detection;rapid diagnosis;Research;research clinical testing;Resolution;Resource-limited setting;Resources;Right Ventricular Dysfunction;Sensitivity and Specificity;skills;Software Tools;supervised learning;Symptoms;System;Techniques;Technology;Testing;Therapeutic Intervention;Time;tool;Training;Ultrasonography;ultrasound;United States;United States Food and Drug Administration;Variant;Work

PROJECT_TITLE: Automated Sonographic Detection of Pulmonary Embolism Using Machine Learning Algorithm

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  The fetal environment substantially influences risk for severe mental illnesses (SMI), some of which do not fully emerge until early adulthood. The proposed studies will build upon our previous cross-sectional work suggesting that increased exposure to folic acid during early pregnancy confers protection against postnatal SMI risk through longitudinal effects on cerebral cortical development. We will conduct prospective MRI, clinical, and cognitive assessments of children who are at clinical high risk for SMI, to determine whether exposure to folic acid supplements early in pregnancy favorably alters their neurodevelopmental trajectories and risk for psychopathology in adolescence, and explore neural mechanisms that could mediate these effects.

PI_NAMEs: DOYLE, ALYSA E;ROFFMAN, JOSHUA LAWRENCE (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Accounting;Adolescence;Adult;Adverse effects;Age;autism spectrum disorder;autistic children;Biological;Birth;Blood;Brain;Buffers;Categories;Cerebral cortex;Child;Child Behavior Checklist;Clinical;Clinical assessments;Clinical Research;cognitive testing;cohort;Conceptions;Cross-Sectional Studies;Data;Development;Dimensions;Discipline of obstetrics;Disease;early childhood;early pregnancy;Electronic Health Record;emerging adult;Environment;Environmental Risk Factor;Epigenetic Process;Exposure to;fetal;Folic Acid;Folic acid fortification;folic acid supplementation;follow-up;Functional Magnetic Resonance Imaging;Funding;Genetic Load;Genetic Risk;Genetic study;Genomics;Grain;Health Benefit;help-seeking behavior;Heritability;high risk;improved;Incidence;Infection;Infrastructure;interest;Intervention;Israel;Laboratories;Life;Link;Magnetic Resonance Imaging;Malnutrition;Maternal Exposure;Measures;Mediating;Mental disorders;Modeling;Neurocognition;Neurocognitive;neuromechanism;neuroprotection;Noise;Norway;obstetrical complication;Outcome;Panthera leo;Patients;Pattern;Population;population based;postnatal;precision medicine;Pregnancy;prenatal;prenatal exposure;prospective;Prospective Studies;Prospective, cohort study;protective factors;Psychopathology;psychosis risk;Public Health;Recommendation;Records;recruit;Recurrence;Research Design;Risk;Risk Factors;risk mitigation;Risk Reduction;risk stratification;Schizophrenia;severe mental illness;Siblings;Signal Transduction;Spinal Cord;Symptoms;Testing;Thick;Thinness;Time;trend;Variant;Work;Youth

PROJECT_TITLE: Longitudinal neuroprotectiveeffects of periconceptional folic acid supplements in help-seeking youth with psychiatric symptomsand healthy controls

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Neurosciences;Pain Research;Patient Safety;Pediatric;Prevention;Sleep Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The public health goals of the candidate's research program are to examine pathways linking sleep and pain, which is key to unlocking new advances in treatment to prevent chronic pain. If perioperative melatonin is shown to be feasible in a pilot trial, this will allow efficacy testing of this complementary treatment, addressing a critical need for non-opioid options to reduce pain. In addition, the candidate will expand her interprofessional mentoring program to rigorously train the next generation of patient-oriented pain researchers equipped to address the pain epidemic facing our nation.

PI_NAMEs: RABBITTS, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Acute Pain;Address;Adherence;Adolescence;Adolescent;Adult;Age;Anesthesiology;Anxiety;Applications Grants;Award;biopsychosocial;career;Childhood;Chronic;chronic musculoskeletal pain;chronic pain;Clinical;clinical pain;Clinical Trials;cohort;Collaborations;Complementary therapies;Data;Dose;effectiveness evaluation;efficacy testing;efficacy trial;Enrollment;Enteral;Epidemic;Event;experience;feasibility trial;Fellowship;fibromyalgia patients;follow-up;forging;Funding;Generations;Health;health goals;health related quality of life;high risk;Hormones;improved;improvement on sleep;innovation;Intervention;Knowledge;life span;Link;longitudinal design;Mediating;Mediator;Medicine;Melatonin;Mentors;Mentorship;Methodology;Methods;mHealth;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;minimal risk;Modeling;modifiable risk;Monitor;Musculoskeletal;Musculoskeletal Pain;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Needles;next generation;non-opioid analgesic;novel;Operative Surgical Procedures;Outcome;Pain;pain chronification;Pain intensity;Pain interference;pain processing;pain reduction;Pain Research;pain sensitivity;Parents;Pathway interactions;patient oriented;Perioperative;Persistent pain;Physicians;pilot trial;poor health outcome;Population;Postdoctoral Fellow;Postoperative Pain;Postoperative Period;prevent;Prevention;preventive intervention;primary outcome;programs;Psychophysics;psychosocial;Puberty;Public Health;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;resilience;resilience factor;Risk;Risk Factors;Risk Marker;Role;Safety;Science;Scientist;secondary outcome;sensory mechanism;sex;side effect;skills;Sleep;Sleep disturbances;sleep quality;sleep regulation;Sleep Wake Cycle;Spinal Fusion;Spine surgery;Teenagers;Testing;Time;Training;training opportunity;Training Programs;Universities;Washington;Youth

PROJECT_TITLE: Preventing the Transition from Acute to Chronic Musculoskeletal Pain in Adolescents after Surgery: The Role of Sleep

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Complementary and Integrative Health;Heart Disease

PHR: Project Narrative Postoperative atrial fibrillation (POAF) is the commonest complication after open heart surgery and is a growing clinical problem. Also, POAF is no longer considered a transient one-time event as a longer duration of POAF is associated with worsened long-term survival and risk of AF recurrence. The studies in this research proposal will change the paradigm for the treatment of POAF following open heart surgery, and contribute significantly to the management of this common complication.

PI_NAMEs: LEE, SEUNGYUP  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Algorithms;Anatomy;Arrhythmia;Atrial Fibrillation;atrioventricular node;Behavior;canine model;Canis familiaris;Cardiac Surgery procedures;Characteristics;Clinical;Clinical Trials;Complication;connexin 40;Connexin 43;Data;density;Electric Countershock;Electrodes;Electrophysiology (science);epicardial mapping;Epicardium;Event;Fatty acid glycerol esters;Health Care Costs;Heart Atrium;Heart failure;hemodynamics;Hypotension;improved;Incidence;Inflammation;insight;Left;Length;Length of Stay;Maintenance;Maps;Modality;Modeling;Morbidity - disease rate;mortality;Muscle Cells;Myocarditis;Nonpharmacologic Therapy;Outcome;Patients;Pericarditis;Pharmaceutical Preparations;Play;Postoperative Period;Prevention;Proliferating;Pulmonary veins;Recurrence;Research Proposals;Risk;Role;Secure;Sinus;Site;Sterility;Stroke;Surgeon;Testing;Therapeutic;Time;treatment strategy;Ventricular

PROJECT_TITLE: Non-Pharmacologic Approach to Rhythm Control and Rate Control of Postoperative Atrial Fibrillation.

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The pathogenesis of Inflammatory Bowel Disease (IBD) involves interactions between genetics, environmental and microbial factors, and immune responses with an inherent complexity making prevention and cure elusive. Current cohorts do not allow for characterization of the evolution of this multifactorial milieu before disease inception limiting our ability to predict disease. We aim, in a novel, pre-disease-inception, high-risk, familial IBD cohort to characterize the microbial and genetic contributions to IBD to allow for improved stratification of those at highest risk for developing IBD.

PI_NAMEs: SPENCER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Affect;Age;Area;Award;Birth Order;career;career development;Characteristics;Childhood;Chronic;Clinical;clinical care;clinical center;Clinical Immunology;cohort;Cohort Studies;Collaborations;Complex;Data;Development;Diagnosis;Disease;disorder prevention;disorder risk;dysbiosis;Enrollment;Environment;Event;Evolution;Faith;Family;Family member;Family Research;Feces;First Degree Relative;Funding;Gastroenterology;Genetic;Genetic Risk;Genome;genome sciences;genomic data;Genomics;Goals;Heritability;high risk;Immune;Immune response;improved;indexing;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Institution;International;Leadership;Life;Link;Longitudinal cohort;Measures;medical schools;member;Mentors;metabolome;metabolomics;Metagenomics;microbial;microbiome;microbiome research;mid-career faculty;Modeling;novel;Parents;Participant;Pathogenesis;patient oriented;Patients;personalized medicine;Phase;polygenic risk score;Population;pre-clinical;Prevention;Prevention Measures;professor;programs;random forest;Relative Risks;Research;Research Personnel;Risk;Risk Factors;risk prediction model;risk stratification;risk variant;Role;Running;Shapes;Siblings;skills;Statistical Methods;Stratification;Training Activity;Twin Studies;United States National Institutes of Health;Validation;ward

PROJECT_TITLE: The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project narrative Mosquitoes are exceptionally prone to dehydration due to high water loss rates, but few integrative studies have examined the comprehensive impact of dehydration on mosquitoes. In this study, we will characterize how periods of dehydration alter the behavior and physiology of mosquitoes, specifically in relation to their ability to act as disease vectors. Information generated from this proposed research will be critical to understanding the impact that water availability has on mosquito biology and pathogen transmission.

PI_NAMEs: BENOIT, JOSH B. (contact);XIAO, YANYU

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Affect;Area;Behavior;Behavior Therapy;Behavioral;Biochemical;Biological;Biology;Blood;carbohydrate metabolism;climate variability;Comparative Study;CRISPR/Cas technology;Culex pipiens;Culicidae;Dehydration;Desiccation;Detection;Development;differential expression;disease model;disease transmission;Disease Vectors;drinking water;Droughts;Dryness;Experimental Designs;experimental study;Exposure to;feeding;Genes;genome editing;Goals;Habitats;High temperature of physical object;Homeostasis;Hour;Humidity;Hydration status;Immune;Immune response;Immunity;improved;Individual;Ingestion;Insecta;knock-down;mathematical model;Metabolism;Modeling;Mosquito-borne infectious disease;Organism;pathogen;Phenotype;Physiological;Physiology;Predisposition;preference;Proteins;Reproduction;Research;response;RNA Interference;Role;Seasons;Sensory;sensory mechanism;Sensory Receptors;Sindbis Virus;Stress;Temperature;Transgenic Organisms;transmission process;vector;vector competence;vector mosquito;vector-borne;Viral;viral transmission;Virus;Water;West Nile virus;Yellow Fever;Zika Virus

PROJECT_TITLE: Mosquito hydration status as a mechanism that alters pre-feeding host interactions and post-feeding physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE It is not known how the species safeguards its genome from the mutagenic insults of the fragile left-handed Z- DNA structure, which can form in the cells at simple repeat sequences. We discovered a natural biological process that eliminates Z-DNA structure in mammalian germ cells, and a novel DNA-binding protein that carries out this function, positing this protein as the guardian of the germ line. We will employ a combination of genetics, in vivo epigenome mapping, and in vitro biochemistry approaches to determine the molecular mechanisms and significance of managing Z-DNA structure in the germ line.

PI_NAMEs: SZABÓ, PIROSKA EDIT (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Adopted;Affect;Affinity;B-DNA;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Biological Process;BTB/POZ Domain;Cell Culture Techniques;Cells;Cellular biology;Chromosomal Rearrangement;Chromosome Deletion;Circular Dichroism;Dependence;Development;DNA;DNA Double Strand Break;DNA mapping;DNA Methylation;DNA Modification Methylases;DNA Sequence Rearrangement;DNA Structure;DNA-Binding Proteins;DNMT3a;EMSA;Enzymes;Epigenetic Process;epigenome;epigenomics;fetal;Generations;Genetic;Genetic Models;Genome;genome integrity;genome-wide;Germ Cells;Germ Lines;Grant;Human;Immunohistochemistry;In Vitro;in vivo;Left;Location;male;Mammalian Cell;Maps;Measures;Methods;Methylation;Methyltransferase;Modeling;Molecular;Monitor;Mus;mutant;Mutant Strains Mice;Mutation;mutation assay;next generation;novel;Nucleosomes;Organism;Population;Pregnancy;Process;Proteins;Purines;Pyrimidine;Refractory;Role;Short Tandem Repeat;Site;sperm cell;Spermatocytes;Tandem Repeat Sequences;Testing;Time;Transgenic Mice;Variant;Z-Form DNA;Zinc Fingers

PROJECT_TITLE: A NOVEL PROCESS SAFEGUARDS GENOME INTEGRITY IN THE MAMMALIAN GERM LINE

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]