NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: OUYANG, JINSONG  (contact)

PROJECT_TERMS: 18F-fluorothymidine;3-Dimensional;Acceleration;accurate diagnostics;Address;Algorithms;anatomic imaging;Anatomy;Area;Artificial Intelligence;artificial intelligence model;autoencoder;Cephalic;Clinical;Data;data analysis pipeline;Data Set;deep learning;deep neural network;denoising;Development;Diagnostic;Disease;Disease Progression;Dose;Early treatment;Environment;Evaluation;experience;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;FOLH1 gene;Funding;Goals;Human;Image;image reconstruction;image translation;imaging modality;Imaging technology;improved;innovation;Intervention;Knowledge;large-scale imaging data;Lead;learning strategy;Longitudinal Studies;Magnetic Resonance Imaging;Markov Chains;Medical;Medical Imaging;Medicine;Methodology;Methods;Modeling;molecular imaging;Motion;Network-based;Noise;novel;Organ;parametric imaging;Physics;Positron-Emission Tomography;precision medicine;Protocols documentation;quantitative imaging;radiotracer;rate of change;reconstruction;Research;response;Scanning;shot learning;Signal Transduction;simulation;Solid;Source;Standardization;success;tau Proteins;Technology;technology development;Time;Tracer;Training;training data;transfer learning;treatment response;ultra high resolution;Uncertainty;uptake

PROJECT_TITLE: TR&D2: Advanced Statistical Image Reconstruction & Physics Informed Artificial Intelligence for Quantitative PET/MR


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: NORMANDIN, MARC DAVID (contact)

PROJECT_TERMS: 3-Dimensional;Administrative Supplement;Affect;Affinity;Animal Model;Animals;Binding;Biodistribution;Biological;Biological Markers;Biological Process;Body System;Brain;Cardiac;Cardiology;cell type;Cells;Cellular Membrane;Collaborations;Complement;Contrast Media;Custom;Data;data acquisition;Degenerative polyarthritis;Dementia;Demyelinations;design;Development;Disease;electric field;Endocrinology;Equation;extracellular;Extracellular Space;Family suidae;FDA approved;ferumoxytol;First Independent Research Support and Transition Awards;first-in-human;functional group;Functional Magnetic Resonance Imaging;Funding;gray matter;Half-Life;Heart;Heart Atrium;human subject;Image;Image Analysis;image translation;imaging agent;imaging modality;imaging properties;Imaging technology;Immune;immune function;immune imaging;Immune response;Impairment;improved;in vivo;Incubated;Inflammation;Inflammatory;Kidney;Kinetics;Label;Lesion;Liver;Macrophage;Magnetic nanoparticles;Magnetic Resonance Imaging;Maps;Measurement;Measures;Membrane Potentials;Methodology;Methods;Microelectrodes;Mitochondria;mitochondrial membrane;Modality;Modeling;molecular imaging;Monkeys;monocyte;Mononuclear;Motion;multimodality;Multiple Sclerosis;Mus;Muscle;Myelin;Myocardium;nanoparticle;nanoparticle drug;nitroxyl;nonhuman primate;novel;novel imaging technology;novel marker;off-label use;Oncology;Oryctolagus cuniculus;Oxidative Stress;Penetration;Peptides;pharmacokinetic model;physiologic model;Physiological;Physiological Processes;Physiology;Positron-Emission Tomography;Potassium Channel;pre-clinical;Preparation;Primates;Property;Prostate;Protamines;Protocols documentation;Radiochemistry;Radiolabeled;Radiometry;radiotracer;Resolution;Rodent Model;Scanning;Sensory Receptors;Services;Signal Transduction;Skeletal Muscle;Specificity;synergism;T-Lymphocyte;tau Proteins;Techniques;Technology;Testing;Time;Tissues;Tracer;Translations;Traumatic Brain Injury;Validation;Ventricular;voltage;white matter;Work

PROJECT_TITLE: TR&D3: Novel Imaging Agents & Physiological Modeling for Quantitative PET/MR


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Heart attacks and stroke are the most common causes of death and disability in the United States. Well-trained scientists are needed to investigate the causes and complications of these events. This research training program is designed to prepare early career scientists to become independent investigators and leaders who can use a multidisciplinary approach to discover answers that will lead to the prevention and treatment of heart disease, hypertension and stroke.

PI_NAMEs: BOPASSA, JEAN CHRISOSTOME  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Vascular Diseases

PROJECT_TITLE: Pathobiology of Occlusive Vascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Dementia with Lewy bodies (DLB) is a dementia syndrome that is often influenced by both Lewy body disease (LBD) and Alzheimer's disease (AD) pathologies. Mild Cognitive Impairment (MCI) with DLB features is now recognized as an early stage of DLB. Determining the autopsy-confirmed multi-modal imaging biomarkers of MCI with DLB features that are associated with disease progression is critical for clinical trials that target specific pathologic components in DLB patients early in the disease process, when preventing or delaying or progression to dementia is possible.

PI_NAMEs: BOEVE, BRADLEY F;KANTARCI, KEJAL  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Age;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Attention;Autopsy;Biological Assay;Biological Markers;biomarker identification;biomarker selection;Cerebrovascular Disorders;Clinic;Clinical;Clinical Trials;Cognitive;Data;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;Disease;Disease Progression;dopamine transporter;Evolution;Florida;Goals;Guidelines;Image;imaging biomarker;Impaired cognition;Individual;Investigation;Lesion;Lewy Body Disease;Life;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Memory;mild cognitive impairment;multidisciplinary;Multimodal Imaging;multimodality;Names;novel marker;Outcome;Parkinson Disease;Participant;Pathologic;Pathology;patient population;Patients;Phase;Phenotype;Pittsburgh Compound-B;Positron-Emission Tomography;predictive marker;Preparation;prevent;Probability;Process;programs;Progress Reports;progression risk;protein misfolding cyclic amplification;Proteins;Research Personnel;risk prediction;Sampling;serial imaging;sex as a biological variable;single photon emission computed tomography;Site;Specificity;stem;Syndrome;Time;Tissues;treatment response;visual processing

PROJECT_TITLE: Longitudinal Imaging Biomarkers of Prodromal DLB


PI_NAMEs: GROGG, KIRA  (contact)

PROJECT_TERMS: Anatomy;Clinical;clinical application;Collaborations;Communities;Complex;COVID-19 pandemic;Data Set;Dedications;Development;Discipline of Nuclear Medicine;Doctor of Philosophy;Educational Materials;Educational process of instructing;Educational workshop;Engineering;Environment;experience;Funding;Goals;graduate student;Growth;Image;Image Analysis;image translation;imaging science;imaging system;Imaging technology;Industrialization;innovation;instrumentation;International;Journals;lectures;Magnetic Resonance Imaging;Manufacturer;Marketing;Medical Imaging;meetings;Methodology;Mission;Modality;molecular imaging;Motion;Motivation;National Institute of Biomedical Imaging and Bioengineering;novel;nuclear science;Peer Review;PET/CT scan;Physics;Positron-Emission Tomography;program dissemination;programs;Publications;Publishing;Research;Research Personnel;Resources;Scientific Advances and Accomplishments;Scientist;Site;Societies;symposium;Techniques;Technology;technology development;Training;Training and Education;training opportunity;Training Programs;Translations;undergraduate student;Visit;web page;web server;web site

PROJECT_TITLE: Training & Dissemination Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE While mild traumatic brain injury (mTBI) can lead to cognitive difficulty, little is known about how mTBI may af- fect driving, especially among teen drivers who are at an increased risk of both mTBI and motor vehicle colli- sions compared to other age groups. This multi-site study will longitudinally evaluate the effects of mTBI on driving, from acutely post-injury to symptom resolution, among teen drivers with mTBI as compared to matched healthy controls using high fidelity driving simulators and self-reports. Findings will provide scientific evidence to inform the development of clinical guidelines regarding when teens can safely return to drive after mTBI.

PI_NAMEs: STAVRINOS, DESPINA ;YANG, JINGZHEN GINGER (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acute;Affect;Age;age group;Australia;Automobile Driving;Canada;Clinical;clinical development;Clinical Practice Guideline;Cognitive;cognitive load;distraction;driving behavior;driving performance;Enrollment;evidence base;experience;experimental study;Functional impairment;Geography;Goals;Guidelines;Health Personnel;Hour;Impaired cognition;improved;Individual;Injury;innovation;Longitudinal Studies;Mediating;mild traumatic brain injury;Neurocognitive;Neurocognitive Deficit;Outcome;Participant;Patient Self-Report;Patients;Performance;Physicians;Pilot Projects;Protocols documentation;Psyche structure;Race;Reaction Time;Recommendation;Recording of previous events;Recovery;recruit;Research;Resolution;Resources;Rest;Risk;sex;Site;socioeconomic diversity;Speed;Surveys;Symptoms;teen drivers;teen driving;Teenagers;Testing;therapeutic target;Time;Vehicle crash

PROJECT_TITLE: Longitudinal Assessment of Driving After Mild TBI in Teens

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Considerable preclinical and clinical evidence has emerged in recent years suggesting that the poor prognosis faced by glioma patients is in part due to the lack of an effective antitumor T-cell response. Here, we will investigate a localized and comprehensive approach of replicating retroviral delivery of RLI, an IL-15 fusion protein, and other immunomodulatory genes as a therapeutic strategy for glioblastoma. Direct stimulation of an anti-tumor T-cell mediated immune response through retroviral delivery of these genes will reverse the T-cell poor nature of glioblastoma without systemic toxicity.

PI_NAMEs: AGHI, MANISH  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Accounting;adaptive immune response;Address;anti-tumor immune response;Antigen Presentation;Biological Availability;Bone Marrow;Brain Neoplasms;CD8B1 gene;cell mediated immune response;Cell Physiology;Cells;Chimeric Proteins;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;CRISPR interference;CRISPR screen;CSF3 gene;CTLA4 gene;cytokine;Cytosine deaminase;Cytotoxic Chemotherapy;Data;Diagnosis;Enzymes;exhaustion;Failure;Gene Delivery;Gene Expression;gene therapy;Genes;Glioblastoma;Glioma;IL7 gene;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immune response;Immunocompetent;immunodeficiency;immunogenic cell death;immunomodulatory strategy;immunoregulation;immunosuppressed;Immunosuppression;Immunotherapy;improved outcome;in vivo;Inhibition of Apoptosis;Innate Immune Response;innovation;Interleukin-15;interleukin-15 receptor;interleukin-21;ipilimumab;knock-down;Libraries;Malignant Neoplasms;Memory;Memory impairment;Modeling;mouse model;Mouse Strains;Mus;Nature;neoplastic cell;new technology;Nivolumab;novel;novel strategies;Organ;Pathway interactions;Patients;pembrolizumab;phase III trial;pre-clinical;Prodrugs;Prognosis;programmed cell death protein 1;Proliferating;Proteins;Resistance;resistance mechanism;response;Retroviridae;RNA;single cell sequencing;Surface;System;systemic toxicity;T cell response;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;Transgenic Mice;translational potential;tumor;tumor growth;tumor microenvironment;Viral;Virus;Work

PROJECT_TITLE: Retroviral RLI immunomodulatory gene therapy for glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Drug development for treating Alzheimer's disease has been very challenging due to the differential responses of patients to different treatments. This project will develop machine learning models to identify patient subgroups who respond differently to treatments. This will result in smaller, less expensive studies, more targeted Alzheimer's disease clinical trials that expose fewer patients to experimental medications to which they are unlikely to respond.

PI_NAMEs: JIANG, XIAOQIAN ;KIM, YEJIN  (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Address;Affect;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Anti-Hypertensive Agents;Atrophic;Characteristics;Chronic;Clinical Data;Clinical Trials;Cognitive;comorbidity;Data;data access;Data Set;deep learning;Disease;distributed data;drug development;Ensure;Failure;federated learning;forest;Friends;Future;Galantamine;Gender;Gold;Grain;Hippocampus;Impaired cognition;Individual;individual response;informatics tool;innovation;Knowledge;Learning;machine learning model;machine learning prediction;Modality;Modeling;Nerve Degeneration;Obesity;Outcome;outcome prediction;Outsourcing;patient population;patient response;patient subsets;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase II Clinical Trials;phase III trial;Phenotype;Plasma;Policies;Population;Prediction of Response to Therapy;predictive modeling;privacy preservation;prospective;randomized, clinical trials;Reporting;Research;response;Risk;Sample Size;sex;Subgroup;Subjects Selections;success;therapy development;Training;transmission process;treatment effect;treatment response

PROJECT_TITLE: Harmonizing multiple clinical trials for Alzheimer's disease to investigate differential responses to treatment via federated counterfactual learning

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In patients with urinary stone disease, several knowledge gaps persist regarding the impact of fluid therapy in preventing stone recurrence, and the optimal care after insertion of a ureteral stent (a thin tube inserted into the ureter to prevent obstruction of the urine flow from the kidney). This application will address these gaps by assessing the effectiveness and safety of new behavioral strategies to increase urine fluid intake, and evaluating factors contributing to discomfort following stent insertion, with the ultimate goal of improving patient care.

PI_NAMEs: LAI, HING HUNG HENRY (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;arm;associated symptom;Behavior Therapy;Behavioral;Biological;Blood;Caring;Child;Childhood;Clinic;Clinical;clinical center;Clinical Research;cohort;Collection;Communities;cost;COVID-19;COVID-19 pandemic;Data;Data Analyses;Data Collection;Deposition;design;Disease;Effectiveness;effectiveness evaluation;Endocrinologist;Enrollment;Ensure;evaluation/testing;Event;Excision;experience;financial incentive;Fluid Therapy;follow-up;Follow-Up Studies;Foundations;Funding;Future;Goals;Health;health care service utilization;Hydration status;improved;Individual;innovation;insight;Intake;Intervention;Interview;Investigation;Kidney;Kidney Calculi;Knowledge;Lifting;Liquid substance;Lived experience;Manuscripts;Measures;Medical;Medicine;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;observational cohort study;Obstruction;Operative Surgical Procedures;Output;Pain;Participant;participant enrollment;Patient Care;Patient Recruitments;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perioperative complication;Philadelphia;Plasma;Preparation;Prevalence;prevent;Prevention;primary endpoint;Problem Solving;Procedures;programs;prospective;Prospective, cohort study;Psychosocial Assessment and Care;Public Health;Publications;Questionnaires;radiologist;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Recurrent disease;Regimen;Reporting;repository;Research;Research Design;Research Institute;Research Personnel;Resources;response;Safety;Sampling;Scientist;Sensory;Serum;Site;Societies;Stents;Structure;success;Symptoms;Texas;therapy design;Thinness;Time;Touch sensation;treatment arm;Tube;Universities;Ureter;Ureteroscopy;urinary;Urinary Calculi;Urine;urologic;Urologist;Visit;Washington;Water;Whole Blood

PROJECT_TITLE: Extension of Urinary Stone Disease Research Network (USDRN) at Washington University


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Pregnancy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative  Human nephrogenesis is complete by 34-36 weeks gestation, with 60% of nephrons forming during the third trimester. Given improved survival of periviable gestational ages coupled with the fact that nephrogenesis continues for no more than 40 days after premature birth, preterm infants are at the low end of nephron endowment and at greater risk for chronic kidney disease and end stage renal disease in adulthood. Uncovering the molecular mechanisms governing primate-specific late gestation nephrogenesis will have a positive impact on the health of preterm infants by identifying potential druggable targets that will help extend this critical period postnatally.

PI_NAMEs: SCHUH, MEREDITH  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Adult;Advisory Committees;age related;age related changes;Anatomy;Animals;ATAC-seq;Award;Binding Sites;Bioinformatics;Biological Models;Birth;Callithrix;Callithrix jacchus jacchus;career development;Career Mobility;Cell Nucleus;cell stroma;Cells;certificate program;Chronic Kidney Failure;Coupled;CRISPR/Cas technology;critical period;Data;Data Set;Development Plans;druggable target;End stage renal failure;Endowment;Environment;epigenome;Fetal Kidney;Freezing;Future;gene regulatory network;Gene set enrichment analysis;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Germ Lines;Gestational Age;Goals;Health;high risk;Human;improved;In Situ Hybridization;Kidney;Kidney Diseases;Knowledge;laboratory experience;laser capture microdissection;Lateral;Life;Macaca mulatta;Maps;Metanephric Diverticulum;Methods;Modeling;Molecular;Molecular Biology;Morphology;multiple omics;Mus;nephrogenesis;nephron progenitor;Nephrons;nonhuman primate;novel;Outcome;Pathway interactions;periviable;Population;postnatal;postnatal period;Pregnancy;premature;Premature Birth;Premature Infant;prevent;Primates;Process;Research;Rhesus;Risk;RNA;Sampling;Second Pregnancy Trimester;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;stem cells;System;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Third Pregnancy Trimester;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;TWIST1 gene;With laterality

PROJECT_TITLE: Bridging the gap of late gestation human nephrogenesis using a non-human primate model

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Infectious Diseases;Liver Disease;Microbiome;Prevention;Sarcopenia;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: As one of the largest hospital systems nationally with a consistent referral pattern of patients with cirrhosis, we propose to be a part of the Liver Cirrhosis Network. We will establish a longitudinal cohort of cirrhotic patients with and without human immunodeficiency virus infection to enhance our mechanistic understanding of progression of disease, development of complications and predictors of clinical outcomes. We will also participate in a randomized placebo controlled trial to evaluate the benefits/safety of simvastatin in cirrhosis.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: adverse outcome;Affect;Age;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;Amines;Ammonia;Angiogenesis Inhibitors;Anti-Inflammatory Agents;Antioxidants;Architecture;Ascites;biobank;Biological Markers;Cause of Death;Cessation of life;Child;chronic liver disease;Cirrhosis;Clinic;Clinical;clinical center;clinical practice;Clinical Trials;clinically significant;Cohort Studies;comorbidity;Complication;Computerized Medical Record;cost;Cross-Sectional Studies;Data;Databases;Development;Diagnosis;Diagnostic;digital applications;digital health;Disease;Disease Outcome;Disease Progression;Encephalopathies;end stage liver disease;Enrollment;Ethnic Origin;Etiology;Evaluation;Event;Fibrosis;follow-up;frailty;Functional disorder;Gender;gut microbiome;health management;Health system;Hemorrhage;Hepatic;High Prevalence;high risk;HIV;HIV Infections;Hospitals;Human;human data;Hydroxymethylglutaryl-CoA Reductase Inhibitors;Icterus;immunodeficiency;Impairment;improved;improved outcome;Infection;Injury;innovation;interest;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Lobular;Long-Term Care;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Measures;metabolomics;microbial;Modeling;mortality;Muscle;Muscular Atrophy;Myopathy;new technology;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel marker;novel therapeutics;Organ;Outcome;participant enrollment;Pathogenesis;Patient Care;patient population;Patients;Pattern;pharmacologic;Pilot Projects;Placebos;Plasma;Play;Portal Pressure;predict clinical outcome;Prevalence;prevent;Primary carcinoma of the liver cells;primary outcome;Productivity;profiles in patients;programs;progression marker;progression risk;prospective;Prospective Studies;Prospective, cohort study;Proteomics;Public Health;Publishing;Quality of life;Randomized;randomized placebo controlled trial;randomized, clinical trials;Randomized, Controlled Trials;Reporting;research clinical testing;response;Risk;Risk Factors;Role;Safety;sarcopenia;Severities;Severity of illness;Simvastatin;Syndrome;System;Telemedicine;televisit;Testing;therapeutic target;United States;United States National Institutes of Health;Virus;Virus Diseases;young adult

PROJECT_TITLE: Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy


NIH_SPENDING_CATS: Chronic Pain;HIV/AIDS;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE Of those with Human Immunodeficiency Virus-1/ AIDS (HIV-1) patients, 60% experience sensory neuropathy (HIV-SN), the most common HIV-1-associated neurological disorder worldwide, for which there is no FDA- approved effective treatment. We will study the mechanisms associated with this nociceptor-based chronic pain in a mouse model, to determine the specific pain pathways that govern SN, which we know are different from central nervous mechanism-related pain. Results will form the basis for developing effective treatments for the HIV -SN patients who now must suffer without hope.

PI_NAMEs: YUAN, SUBO  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Ablation;Acquired Immunodeficiency Syndrome;Acute;Affect;afferent nerve;Afferent Neurons;Agonist;allodynia;Analgesics;antagonist;Antibodies;Axon;Back;Calcitonin Gene-Related Peptide;chronic pain;chronic pain patient;Clinical;comorbidity;Complication;conditional knockout;Data;Denervation;Dependence;Development;Disease;effective therapy;Engineering;Exhibits;experience;Family;FDA approved;Gene Proteins;genetic approach;glial cell-line derived neurotrophic factor;Glycoproteins;Growth;Growth Associated Protein 43;HIV;HIV Envelope Protein gp120;HIV-1;Human;Infection;Label;life span;Ligation;Measures;Mediating;Mediator;Modeling;mouse model;Mus;Nerve Growth Factor Pathway;Nerve Growth Factors;nerve supply;Nervous System Disorder;Neurons;Neuropathy;neurotrophic factor;Nociception;Nociceptors;novel;Pain;pain patient;pain relief;painful neuropathy;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;pharmacologic;Phase;Physiological;planar cell polarity;Play;Posterior Horn Cells;prevent;Proteins;Publications;Reporter;Reporting;Research;Resistance;Role;sensory neuropathy;Severities;Signaling Protein;Skin;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Spinal cord posterior horn;Spinal Ganglia;Spinal nerve structure;Testing;Therapeutic;therapeutic evaluation;Treatment Efficacy;Up-Regulation

PROJECT_TITLE: Pathogenesis of HIV-associated sensory neuropathy

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: Sunnyvale

ORG_NAME: PETCOIL, INC.

PHR: Project Narrative Combining complementary medical imaging modalities such as positron emission tomography (PET) and magnetic resonance imaging (MRI) has shown great promise for multiparametric characterization of disease. The goal of this project is to develop the first portable radiofrequency (RF)-penetrable PET insert optimized for brain imaging that can be installed into any existing MRI system to achieve simultaneous PET/MRI of neurological disease, significantly lowering the cost and hence increasing availability of brain PET/MRI studies to patients worldwide. In addition, the portable PET insert system also achieves significant performance enhancements over state-of-the-art commercially available permanently-integrated PET/MR systems.

PI_NAMEs: CHANG, CHENMING  (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Address;Alzheimer's Disease;anatomic imaging;Brain;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;Clinical;clinical imaging;Coiled Bodies;Collaborations;commercial prototype;commercialization;Computer software;cost;Data;design;detector;Devices;Diagnosis;Disease;Dose;Electronics;Ensure;Epilepsy;experience;first-in-human;flexibility;Goals;Head;Human;human data;human study;Hybrids;hyperphosphorylated tau;Image;imaging capabilities;imaging modality;Industry;Institution;Lesion;Magnetic Resonance Imaging;Marketing;Measures;Medical Imaging;Mental Depression;Mental disorders;Nervous System Disorder;Neurofibrillary Tangles;Neurologic;Noise;Organ;Outcome;Patients;Performance;Phase;Photons;Physicians;Pilot Projects;portability;Positron-Emission Tomography;preservation;progression marker;prototype;Radiation exposure;radio frequency;Radioactive;radiologist;Research;Resolution;scale up;Scanning;Severity of illness;Signal Transduction;Specific qualifier value;Structure;System;Technology;Time;United States;Universities;Validation;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE People living with HIV (PLHIV) have higher rates of tobacco use than the general population and higher rates of disease and death compared with PLHIV who do not use tobacco. Support for tobacco use cessation for PLHIV is needed. This project will evaluate the impact (tobacco use cessation rates) of integrating an intensive tobacco use cessation intervention (compared to integrating a brief intervention) into HIV care clinics in Kisumu County, Kenya.

PI_NAMEs: BIALOUS, STELLA AGUINAGA (contact)

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Address;Adoption;Adult;Africa;Africa South of the Sahara;African;antiretroviral therapy;Behavioral;Biochemical;brief advice;brief intervention;Bupropion;California;Caring;Cessation of life;Clinic;Clinical;clinical care;Communities;Community Health;comorbidity;comparative cost effectiveness;compare effectiveness;coping;cost effective;cost effectiveness;Counseling;Country;County;Data;Death Rate;Diagnosis;Disease;Education;Enrollment;Epidemic;Evaluation;evidence base;evidence based guidelines;experience;Family;formative assessment;General Population;group intervention;Guidelines;Health;Health care facility;Health Personnel;Heart Diseases;high risk;HIV;HIV Infections;improved;innovation;Intervention;Kenya;Malignant Neoplasms;Medical Research;men;Modeling;Morbidity - disease rate;mortality;mortality risk;nicotine replacement;Participant;Patient Self-Report;Patients;Persons;Pharmacotherapy;Policies;Population;Prevalence;Primary Care;primary care setting;quitline;Randomized, Controlled Trials;Recommendation;recruit;reduce tobacco use;Reporting;Research;Research Institute;response;San Francisco;scale up;Services;Site;Smokeless;Smoking;social culture;Socioeconomic Status;symposium;Telemedicine;Telephone;Testing;Tobacco;tobacco cessation intervention;tobacco control;Tobacco Dependence;Tobacco use;Tobacco Use Cessation;tobacco user;Universities;Woman

PROJECT_TITLE: Integrating tobacco use cessation into HIV Care and Treatment in Ministry of Health Facilities in Kisumu County, Kenya


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a major cause of acute and chronic liver failure and is now the most common reason for liver transplantation in the U.S. Historically, transplant centers have required at least 6 months of alcohol abstinence before considering patients with ALD for liver transplant; however early liver transplant for patients with severe ALD with less than 6 months of alcohol abstinence can save lives. This multi- center study will examine the patient selection process for early liver transplantation, identify strategies most helpful to prevent return to alcohol use and to optimize long-term health after transplant.

PI_NAMEs: BITTERMANN, THERESE ;SERPER, MARINA  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Acceleration;access disparities;Accounting;Acute;addiction;Address;Adult;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;American;Ancillary Study;Behavior Therapy;Behavioral;biobank;Blood;candidate selection;Cardiovascular system;Caring;Cessation of life;Chronic;Cirrhosis;Clinical;Clinical Pathways;clinical predictors;cohort;community-level factor;comorbidity;Consensus;Continuity of Patient Care;Data;data repository;deprivation;disorder control;drinking;effective therapy;effectiveness evaluation;efficacy evaluation;Eligibility Determination;end stage liver disease;Enrollment;Evaluation;Event;Exclusion;experience;Failure;Future;Geography;graft function;Graft Rejection;Health;health care disparity;Health Status;Heavy Drinking;Hepatitis;Heterogeneity;high risk;Hospital Costs;Hospitalization;implicit bias;improved;Incidence;Individual;Interview;Knowledge;Life;Link;Liver;Liver diseases;Liver Failure;liver transplantation;Longitudinal cohort;Malignant Neoplasms;Medical;medication-assisted treatment;meetings;Mental Health;Methods;Midwestern United States;Modeling;mortality;mortality risk;Multicenter Studies;multilevel analysis;Natural History;Neighborhoods;Organ;organ allocation;Outcome;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;Policies;prevent;Procedures;Process;Prognosis;Prognostic Factor;prolonged abstinence;prospective;psychosocial;Psychosocial Factor;Quality of life;radiological imaging;recruit;Risk;risk prediction;Safety;Sample Size;Selection Criteria;Site;sobriety;social health determinants;Social support;sociodemographics;Sodium Chloride;Source;Standardization;Substance Use Disorder;Systematic Bias;Tissue Donors;Tissues;transplant centers;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment program;Urine;Waiting Lists

PROJECT_TITLE: 2/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Neurosciences;Opioids;Pain Research;Patient Safety;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Approximately 20% of patients who undergo surgery develop chronic pain, and while chronic postsurgical pain (CPSP) is highly associated with impaired functional recovery and persistent opioid use and dependence, current standard postoperative multimodal analgesia is only moderately effective for its prevention. In a three- arm randomized controlled trial, we aim to study the effectiveness of adding perioperative continuous or single- bolus ketamine to routine postoperative care, for the prevention of post-mastectomy pain syndrome (PMPS), one of the most common CPSP conditions. Ketamine is a low risk treatment option that is easy to implement in a wide range of clinical settings, and thus our proposal can substantially impact postoperative pain management, and in doing so can contribute significantly to our combat against the opioid epidemic.

PI_NAMEs: DOAN, LISA ;WANG, JING  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Absence of pain sensation;Acetaminophen;Acute;Acute Pain;Agreement;American;Anesthesia procedures;Anxiety;anxiety treatment;arm;Bolus Infusion;breast surgery;Breast-Conserving Surgery;Brief Pain Inventory;cancer pain;Chronic;chronic pain;Clinical;Clinical and Translational Science Awards;cohort;combat;Conduction Anesthesia;Consent Forms;Continuous Infusion;cost effective;Data Analyses;Data Collection;data management;Databases;Development;Double-Blind Method;Effectiveness;effectiveness research;effectiveness study;effectiveness testing;effectiveness trial;efficacy testing;Emergency Medicine;Enrollment;Functional impairment;Goals;Guidelines;high reward;high risk;Hospitals;Hour;improved;Incidence;Information Dissemination;Infrastructure;Infusion procedures;innovation;Intervention;Ketamine;Link;Lymph Node Dissections;Machine Learning;machine learning model;Malignant Breast Neoplasm;Mastectomy;Measures;Medicine;Mental Depression;Methods;Modeling;Mood Disorders;Moods;multimodality;Nature;Neuropathy;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opiate Addiction;opioid epidemic;opioid sparing;opioid use;Pain;pain catastrophizing;Pain management;Pain Measurement;participant retention;Patients;payment;Perioperative;Phase;pilot trial;Placebos;Play;Postoperative Care;Postoperative Pain;Postoperative Period;precision medicine;predictive marker;prevent;Prevention;primary endpoint;Protocols documentation;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Recovery of Function;recruit;Regimen;Reporting;Risk;Risk Factors;Role;Saline;secondary analysis;secondary endpoint;Severities;Short-Form McGill Pain Questionnaire;Site;Societies;Statistical Data Interpretation;success;Syndrome;System;Testing;three-arm study;Time;Training;treatment effect;Treatment Efficacy;Treatment Protocols;treatment response;treatment risk;United States National Institutes of Health;Universities;Washington;Woman

PROJECT_TITLE: Optimizing the use of ketamine to reduce chronic postsurgical pain


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The fast-progressing field of mechanobiology has unveiled the key regulatory roles of mechanical forces in biology and advanced our understandings of pathogeneses in numerous disorders. However, the available tools exhibit limited capabilities for precise intracellular mechanical perturbation at cellular/subcellular levels. We will fill the technological gap with a series of genetically encoded in-cellulo mechanical actuators that exhibit precise, multimodal, and high-throughput force exertion and offer a clear pathway towards in-vivo studies, thus facilitating the mechanistic studies in mechanotransduction and helping solve the associated puzzles in pathology.

PI_NAMEs: LIN, DINGCHANG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Protein assemblies as genetically encoded mechanical actuators for intracellular mechanobiology research


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative An evening circadian chronotype (‘night-owls’) is an important contributor to vicious cycles that escalate vulnerability and risk among youth. We propose to study the maintenance of behavior change by conducting a 6-year follow-up of the unique cohort of youth recruited for a prior R01. We will also evaluate if a novel Habit- based Sleep Health Intervention (‘HABITs’) improves the utilization of sleep health behavior and improves sleep and circadian outcomes and functioning in five health-relevant domain outcomes in the short and longer term.

PI_NAMEs: HARVEY, ALLISON G (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 18 year old;Adolescent;Aftercare;Age;Behavior;behavior change;behavior change wheel;Behavior Therapy;Behavioral;behavioral sleep intervention;Biological;Biological Factors;circadian;circadian biology;Cognitive;cohort;cost;Cues;Development;Diagnostic;Dose;Drops;early onset;Effectiveness of Interventions;Emotional;ethnic minority population;Evaluation;Exhibits;experimental study;Focus Groups;follow-up;Funding;Habits;Health;Health behavior;Health Promotion;improved;improvement on sleep;interest;Intervention;intervention effect;Knowledge;Learning;Maintenance;Mediating;Minority Groups;novel;Outcome;Participant;Persons;Phase;Process;programs;psychoeducation;psychosocial;Puberty;racial minority population;Random Allocation;recruit;Reporting;Research;Rewards;Risk;Role;Sampling;Schedule;Science;Seasons;sex;Sleep;sleep behavior;sleep health;social;Strigiformes;Telephone;Testing;Text Messaging;text messaging intervention;theories;Theory of Change;treatment arm;treatment effect;United States National Institutes of Health;Youth

PROJECT_TITLE: Maintaining behavior change: A 6-year follow-up of adolescent 'night-owls' and an evaluation of a habit-based sleep health intervention

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Efficient genome editing of airway stem cells is a critical barrier that has limited the development of ex-vivo gene therapies to treat cystic fibrosis. Our project addresses that critical barrier by developing a universal gene correction strategy in airway stem cells that may be used to treat most CF patients. This knowledge can be further used to develop airway stem cell therapies to treat other airway diseases.

PI_NAMEs: VAIDYANATHAN, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;Agar;Airway Disease;Alleles;Autologous Transplantation;autosome;Base Pairing;Biological Assay;bronchial epithelium;Cause of Death;CD19 gene;Cell Therapy;cell type;Cells;Cellular biology;cellular transduction;Child;clinical application;Code;Complementary DNA;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Delta F508 mutation;Dependovirus;Development;Disease;DNA;Electrophysiology (science);Engineering;Epidermal Growth Factor Receptor;Epithelium;Exons;experimental study;Failure;Frequencies;Future;gene correction;gene editing technology;Gene Frequency;gene therapy;gene-editing approach;Genes;genome editing;Grant;Guide RNA;Immunity;Immunocompromised Host;Immunohistochemistry;Implant;improved;In Vitro;in vivo;Infection;inhibitor;Initiator Codon;insertion/deletion mutation;Ion Channel;Ions;Knowledge;KRAS2 gene;Length;Life Expectancy;Lung;lung failure;lung health;Lung Transplantation;Mediating;Mendelian disorder;mortality;Mus;Mutation;mutation correction;Natural regeneration;next generation sequencing;Oncogenic;Organ;organ transplant rejection;pathogen;Patients;Population;Positioning Attribute;Process;Production;Pulmonary Cystic Fibrosis;pulmonary function;Recurrence;Reporting;Respiratory Tract Infections;response;restoration;Safety;Sampling;side effect;single-cell RNA sequencing;Sinus;small molecule;Solid Neoplasm;Source;stem cell therapy;Stem cell transplant;stem cells;Techniques;Testing;Therapeutic;Therapeutic Intervention;TP53 gene;Trachea;Transplantation;Tumor Suppressor Genes;Tumorigenicity;Viral Vector;Work

PROJECT_TITLE: A universal genome editing strategy to develop an airway stem cell therapy for cystic fibrosis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Problems posed by opioid use disorder are often compounded by comorbid cocaine use. This proposal will use sophisticated preclinical and clinical laboratory models to determine neurobiological mechanisms that contribute to this significant and growing public health concern, and could contribute to the development of novel therapeutic options aimed at reversing opioid and cocaine co-use-induced alterations in the brain.

PI_NAMEs: GIPSON-REICHARDT, CASSANDRA D (contact);STOOPS, WILLIAM WALTON

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acetylcysteine;Animals;Attenuated;Biological Markers;Brain;Chemosensitization;Chronic;Clinical;Cocaine;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;Cocaine withdrawal;comorbidity;Corpus striatum structure;Cues;Dendritic Spines;Dependence;Development;Dose;Drug Controls;Drug usage;Drug Use Disorder;experience;Food;Glutamate Transporter;glutamatergic signaling;Glutamates;Heroin;Homosynaptic Depression;Human;improved outcome;incentive salience;Individual;Intake;Intervention;Intravenous;Knowledge;Laboratories;Magnetic Resonance Spectroscopy;Maintenance;Measures;meetings;Methods;Modeling;motivated behavior;Motivation;multiple drug use;N-Methylaspartate;neural;neurobiological mechanism;neuromechanism;Neurons;novel;novel therapeutics;Nucleus Accumbens;Opioid;Opioid agonist;opioid use;opioid use disorder;opioid withdrawal;Oral;overdose risk;Oxycodone;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phased Innovation Awards;Physical Dependence;Physiological;Placebos;polysubstance abuse;pre-clinical;protein expression;Proteins;Protocols documentation;prototype;Proxy;Public Health;Randomized;Reporting;Self Administration;sex;Specific qualifier value;Stimulus;Synapses;Synaptic plasticity;System;treatment pattern;United States;Up-Regulation;Withdrawal;Work

PROJECT_TITLE: Glutamergic Mechanisms in Opioid and Cocaine Co-Use


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project narrative The UCSD/UCLA DRC will enhance research into the etiology, pathophysiology, treatment, and prevention of diabetes and its complications through facilitation of scientific exchange, and advancement of the outstanding scientific faculty comprising our research base, by providing access to novel biomedical research cores and promoting the careers of young scientists. This will ultimately improve the lives of patients with diabetes, who will benefit from the advancements the center will generate.

PI_NAMEs: SALTIEL, ALAN R. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acceleration;Agreement;Area;Award;base;Basic Science;Beta Cell;Biological Models;Biomedical Research;California;career;Cellular biology;Clinical;clinical investigation;Clinical Research;Collaborations;Complications of Diabetes Mellitus;Dedications;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;Disease;Enhancement Technology;Environment;epidemiology study;Epigenetic Process;Etiology;Expression Profiling;Faculty;flexibility;Fostering;Functional disorder;Funding;Future;genome editing;Genomics;Grant;high risk;Human;Human Genetics;improved;Individual;innovation;insight;Institution;interdisciplinary collaboration;islet;Journals;Knock-in Mouse;Knockout Mice;Laboratories;lectures;Link;lipidomics;meetings;member;Mentors;Mentorship;Metabolic;metabolic phenotype;Metabolism;metabolomics;Mission;Molecular;Mus;Nature;new technology;next generation;novel;Nuclear Receptors;Pathway Analysis;Patients;Peer Review Grants;Physiology;Play;Prevention;programs;Proteomics;Publications;Research;Research Activity;Research Institute;Research Personnel;Research Support;Resource Sharing;Role;Scientific Advances and Accomplishments;Scientist;Series;Services;Signal Transduction;success;symposium;System;Technology;Training;Training Programs;Transgenic Organisms;Translational Research;Translations;type I and type II diabetes;Universities;Update;web site

PROJECT_TITLE: Diabetes Research Center (DRC)


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Applications Grants;Attention;base;Businesses;California;career;career development;Collaborations;Communication;Consultations;Development;Diabetes Mellitus;Diabetes prevention;Discipline;Educational Curriculum;Educational workshop;Elements;Ensure;experience;Faculty;Feedback;Fellowship Program;Fostering;Funding;graduate school;Grant;improved;Infrastructure;Institution;Journals;Leadership;Link;medical schools;member;Mentors;Metabolic;Metabolic Diseases;Metabolism;Mission;next generation;operation;Patients;Peer Review Grants;Play;Prevention;Productivity;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Resource Development;Role;Scientist;Services;System;Technology;Training;translational study;United States National Institutes of Health;Universities;Vision;Visit;web site

PROJECT_TITLE: Administrative Core (with Enrichment Program)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Microbiome;Orphan Drug;Prevention;Rare Diseases;Substance Misuse

PHR: PROJECT NARRATIVE The rise in number of cirrhosis-related deaths and rates of liver cancer create an urgent need to identify better predictors of mortality in cirrhosis and develop better treatments for this disease. Here, we propose to study and monitor a group of patients with cirrhosis to better understand progression of the disease. We will also investigate whether atorvastatin is an effective treatment for cirrhosis patients.

PI_NAMEs: LOOMBA, ROHIT  (contact)

PROJECT_TERMS: Address;adjudication;Alcoholic Liver Diseases;Ancillary Study;Antineoplastic Agents;Area;Ascites;atorvastatin;California;Cardiovascular system;Cause of Death;Cessation of life;Chemopreventive Agent;Chronic Hepatitis C;Cirrhosis;Clinical;clinical infrastructure;Clinical Research;Clinical Trials Design;cohort;Cohort Studies;Compensation;Consent;County;Data;Development;Diagnosis;Disease;Disease Progression;Dose;Double-Blind Method;effective therapy;efficacy evaluation;Etiology;Event;Fibrosis;Future;General Population;Genetic Risk;genetic risk factor;gut microbiome;HCV Liver Disease;health disparity;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatitis B Virus;Hepatitis C virus;Hepatology;Hepatorenal Syndrome;high risk;Hispanic;Hispanic Populations;HIV;Hospitalization;imaging biomarker;Institution;Intervention;lipophilicity;Liver;Liver Cirrhosis;liver stiffness;liver transplantation;Malignant neoplasm of liver;Measures;Medical;men;Meta-Analysis;microbiome;microbiome signature;Monitor;mortality;mortality risk;multi-ethnic;Multi-Institutional Clinical Trial;Natural History;non-invasive imaging;nonalcoholic steatohepatitis;Not Hispanic or Latino;novel therapeutics;Outcome;Outcome Measure;Participant;patient population;Patient Recruitments;Patients;Peritonitis;Pharmacogenetics;Phase;Placebo Control;Placebos;pleiotropism;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;primary endpoint;primary outcome;Property;prospective;Protocols documentation;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Infrastructure;response;Risk;Risk Reduction;Safety;secondary outcome;Site;Testing;Time;treatment response;United States;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: San Diego Cirrhosis Clinical Research Network


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: MELLON, PAMELA L (contact)

PROJECT_TERMS: Acceleration;Animals;Applications Grants;Bacterial Artificial Chromosomes;base;blastocyst;Breeding;Cells;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Complications of Diabetes Mellitus;conditional knockout;Consult;Cre-LoxP;CRISPR/Cas technology;Dedications;design;Development;Diabetes Mellitus;Disease;DNA;Embryo;Embryology;embryonic stem cell;Endocrine;Equipment;Etiology;Experimental Models;FLP recombinase;Frequencies;Future;Genes;Genetic;genetic approach;genetic manipulation;Genetic Research;Genetic Services;Genetic Techniques;genetic technology;Genetically Engineered Mouse;Genome;Harvest;homologous recombination;Human;Human Resources;in vivo;Individual;Injections;innovation;insertion/deletion mutation;interest;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Letters;meetings;member;Metabolic Diseases;Microinjections;Modeling;Modification;Mouse Embryonic Stem Cells;mouse genetics;mouse genome;mouse model;multidisciplinary;Mus;Mutagenesis;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;novel;novel strategies;Obesity;Pathology;prevent;Process;Proteins;Protocols documentation;Quality Control;recombinase-mediated cassette exchange;Research;Research Personnel;Research Project Grants;reverse genetics;RiboTag;RNA;Scheme;Study models;Tamoxifen;Techniques;Technology;Testing;Tetanus Helper Peptide;Tissues;Training;Transgenes;Transgenic Mice;Transgenic Organisms;type I and type II diabetes;web site;zygote

PROJECT_TITLE: Transgenic & Knock-out Mouse


PI_NAMEs: HEVENER, ANDREA L (contact)

PROJECT_TERMS: Acceleration;Acute;adipokines;Aerobic;Animal Model;Animals;Architecture;Area;Arterial Fatty Streak;ATP Synthesis Pathway;base;bench to bedside;biobank;Biogenic Amines;Biological Assay;Biology;Body Composition;California;cell bank;Cell Respiration;cell type;Cells;Cellular Metabolic Process;chemokine;Chronic;Collaborations;Complications of Diabetes Mellitus;Consultations;cost;cost effective;cytokine;Data;Data Analyses;data integration;data repository;Databases;Diabetes Mellitus;diabetes pathogenesis;Disease;Dual-Energy X-Ray Absorptiometry;Environment;Epigenetic Process;Evaluation;Evolution;Exercise;Experimental Designs;Faculty;fatty acid metabolism;Feeding behaviors;Fertilization;Flow Cytometry;Fostering;functional genomics;Gene Expression Profiling;Genetic Engineering;Genetically Engineered Mouse;Genomics;Genus Hippocampus;Glucose;Glucose Clamp;Goals;Homeostasis;hormone metabolism;hormone sensitivity;Hormones;Human;Hyperinsulinism;Image;imager;improved;In Situ;in vivo;Indirect Calorimetry;Individual;Inflammation;Inflammatory;insight;Institution;instrument;instrumentation;Insulin;Insulin Resistance;insulin sensitivity;Investigation;Label;Laboratories;laser capture microdissection;Leadership;Magnetic Resonance Imaging;Maintenance;man;Mass Spectrum Analysis;Measures;media use;member;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic phenotype;Metabolism;Methodology;Microscopy;Mitochondria;Molecular;Molecular Target;Morphology;Movement;Mus;Muscle;new technology;Nuclear Receptors;Obesity;Organelles;Outcome;Oxygen Consumption;Pathway Analysis;Pathway interactions;Performance;Phenotype;Physiological;Physiology;Plasma;Procedures;Production;Productivity;Protocols documentation;Publications;receptor;recruit;Research;Research Personnel;Resolution;Resources;Rodent;Role;Sampling;Scientific Advances and Accomplishments;Series;Services;Signal Pathway;Signal Transduction;Spirometry;Standardization;success;synergism;Techniques;Technology;Time;tissue preparation;Tissues;Tracer;Training;Translational Research;Travel;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Metabolic & Molecular Physiology


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Social Determinants of Health;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE Liver cirrhosis is a serious chronic condition that leads to liver cancer and death. Prevention of complications of cirrhosis is key as once complications arise, the only medically viable option for improved survival is liver transplantation. The mechanisms of disease progression, clinical risks, and therapies to prevent progression are important to reducing cirrhosis burden. The Liver Cirrhosis Network and its proposed studies will enhance understanding of strategies important to prevention of cirrhosis progression including the utility of a commonly prescribed lipid lowering medication, statin, that if beneficial will translate into improved patient care and reduction of the cirrhosis disease complication burden.

PI_NAMEs: HAMEED, BILAL ;KHALILI, MANDANA  (contact)

PROJECT_TERMS: Address;adverse outcome;Anti-Inflammatory Agents;Antiinflammatory Effect;barrier to care;Biological Markers;Biological Specimen Banks;California;cancer risk;Cause of Death;Cessation of life;Cholesterol;Chronic;chronic liver disease;chronic liver injury;Chronic viral hepatitis;Cirrhosis;Clinical;clinical efficacy;Clinical Research;clinical risk;Clinical Trials;clinically significant;cohort;Communities;comorbidity;Compensation;Complication;Conduct Clinical Trials;Country;Data;Diagnostic;Disease;Disease Progression;Disparity;double-blind placebo controlled trial;Double-blind trial;efficacy testing;end stage liver disease;epidemiology study;Epithelium;ethnic minority;Etiology;Evaluation;Failure;fatty liver disease;fibrogenesis;Fibrosis;genetic signature;Genetic Variation;Goals;Health;health care availability;Hepatic;Hepatic Stellate Cell;high risk;HIV Infections;Image;improved;Individual;Injury;Intervention;Knowledge;Link;Lipids;Liver;liver biopsy;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Longitudinal cohort;low socioeconomic status;Malignant neoplasm of liver;Measurement;Measures;Medical;Monitor;Morbidity - disease rate;mortality;Myofibroblast;non-alcoholic;novel;Obesity;Observational Study;Organ;Outcome;oxidized low density lipoprotein;Pathogenesis;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Placebos;Population;Population Heterogeneity;Populations at Risk;Portal Hypertension;Prevalence;prevent;Prevention;Prevention strategy;Preventive measure;Primary carcinoma of the liver cells;problem drinker;Process;prognostic;prospective;Proteins;public health relevance;Quality of life;racial minority;Randomized;Randomized, Controlled Trials;response;Risk;Risk Factors;Role;rosuvastatin;Safety;safety testing;San Francisco;screening;Serology;Signal Pathway;Signal Transduction;Site;social health determinants;Substance Use Disorder;Testing;Therapeutic;Tissues;Transcription Coactivator;Transcriptional Coactivator with PDZ-Binding Motif;Translating;Translational Research;United States;United States National Institutes of Health;Universities;Venous Pressure level

PROJECT_TITLE: Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies


PI_NAMEs: HEINZ, SVEN W (contact)

PROJECT_TERMS: Bioinformatics;Biological Assay;Cells;Chromatin;chromatin immunoprecipitation;Chromium;Computational Biology;Consultations;cost;cost effectiveness;CRISPR screen;crosslinking and immunoprecipitation sequencing;Data Analyses;data quality;deep sequencing;Development;Diabetes Mellitus;diabetes pathogenesis;disease phenotype;Education;Endocrinology;Epigenetic Process;epigenome;epigenomics;Equipment;Experimental Designs;functional genomics;Gene Expression;Genes;Genetic Transcription;genome sequencing;genomic data;Genomic medicine;Genomics;global run on sequencing;Goals;Hi-C;high throughput analysis;High-Throughput Nucleotide Sequencing;Infrastructure;innovation;Link;Massive Parallel Sequencing;Metagenomics;Methodology;miRNA expression profiling;Molecular Genetics;new technology;novel therapeutic intervention;Postdoctoral Fellow;Productivity;programs;Quality Control;recruit;Research;Research Personnel;Resource Sharing;response;ribosome profiling;sequencing platform;Services;Signal Transduction;Signal Transduction Pathway;single cell sequencing;Specialist;student training;Technology;technology platform;Training;transcriptome sequencing;transcriptomics;Transposase;Treatment Protocols;whole genome

PROJECT_TITLE: Epigenetic & Genomics


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ROTTER, JEROME I (contact)

PROJECT_TERMS: African American;Bioinformatics;Blood specimen;California;Candidate Disease Gene;Cells;Chromosome Mapping;clinical investigation;Complex;Complications of Diabetes Mellitus;Computer software;Consult;Coronary heart disease;Custom;Data Analyses;Databases;density;design;Development;Diabetes Mellitus;diabetes mellitus genetics;Disease;DNA;DNA sequencing;Doctor of Medicine;Doctor of Philosophy;Endocrine System Diseases;Epidemiologist;Ethnic Population;exome;exome sequencing;Gene Expression;Genes;Genetic;genetic analysis;genetic epidemiology;Genetic Predisposition to Disease;Genetic Research;Genetic study;Genetic Techniques;genetic variant;genome resource;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Hepatocyte;high risk;Hispanic;Human;Human Genetics;Human Herpesvirus 4;Hypertension;induced pluripotent stem cell;induced pluripotent stem cell technology;Institution;investigator training;lymphoblastoid cell line;Mathematics;member;Metabolic Diseases;metabolomics;Methodology;Methods;Methylation;methylomics;Microvascular Dysfunction;Minority;Minority Groups;Molecular;multi-ethnic;Multiomic Data;multiple omics;Muscle Cells;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;organ growth;Performance;Pharmacogenetics;Phenotype;Population;preservation;Procedures;Proteomics;public database;racial population;recruit;Research;Research Design;Research Personnel;Resources;Risk Factors;RNA;sample collection;Sample Size;Sampling;Services;SNP array;success;Techniques;Technology;Testing;tissue culture;Tissues;Training;transcriptomics;treatment response;Tube;Update;whole genome

PROJECT_TITLE: Human Genetics


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  To date, the Cochrane Eyes and Vision US Project (CEV@US) has spearheaded production of systematic reviews aimed at preventing, diagnosing, or treating eye conditions; these reviews inform decisions about vision care and lead to preservation of sight. We will partner with individual and organizational stakeholders to prepare and update systematic reviews on high-priority topics, influence evidence-based guidelines and knowledge translation activities, build research capacity through training, conduct fundamental methodological research, and disseminate our findings to impact practice.

PI_NAMEs: LI, TIANJING  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Academic Medical Centers;Academy;Achievement;Address;Adverse event;Aging;American;Artificial Intelligence;Authorship;Book Chapters;Caregivers;Caring;Clinical;clinical practice;Clinical Practice Guideline;Collaborations;Communities;Data;data harmonization;Databases;Decision Making;Diagnosis;Economically Deprived Population;Education;Educational Curriculum;Educational workshop;Electronics;Ensure;Equitable healthcare;evidence base;evidence based guidelines;Eye;flexibility;Guidelines;Health;health disparity;health inequalities;Health Personnel;Health Policy;Health Professional;health training;Healthcare;Healthcare promotion;improved;Individual;Infrastructure;innovation;interest;International;Intervention;Investments;Journals;Knowledge;knowledge translation;Language;Libraries;life-long learning;Link;Literature;massive open online courses;Measures;Medical center;meetings;Meta-Analysis;Methodology;Methods;Mission;National Eye Institute;Ophthalmologist;Ophthalmology;Optometrist;Optometry;Outcome;Paper;Patients;Persons;Policies;Population;preservation;prevent;Printing;Production;Professional Organizations;programs;Protocols documentation;Provider;Publications;Publishing;Recommendation;Reporting;Reproducibility;Research;Research Methodology;Residencies;Resources;Science;Slide;social media;socioeconomic disadvantage;Speed;Structure;success;systematic review;Technology;Training;Trust;Underserved Population;Update;Vision;vision science;Visual impairment;Voice

PROJECT_TITLE: Maximizing Use of High-Quality Evidence in Eye Care: Cochrane Eyes and Vision US Project


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: TONTONOZ, PETER J (contact)

PROJECT_TERMS: Acceleration;Achievement;Advertising;Applications Grants;Award;California;Caring;Communities;Data;Data Analyses;Data Collection;Development;Diabetes Mellitus;diabetes risk;Entrepreneurship;Evaluation;experience;Faculty;Fostering;Funding;Future;Generations;Grant;high risk;Infrastructure;innovation;Institution;Intellectual Property;Investments;Journals;Leadership;meetings;member;Mentors;Mission;Modeling;Monitor;next generation;Process;Productivity;programs;Publications;Recording of previous events;Research;Research Personnel;Senior Scientist;Services;skills;success;synergism;Talents;Technology;technology development;Training;translational impact;United States National Institutes of Health

PROJECT_TITLE: Pilot & Feasibility Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE APOE4 is associated with greater cognitive dysfunction in older adults, increases Alzheimer's disease risk up to 12-fold and exacerbates the progression, is inferior or hinders repair mechanisms in vascular dementia, stroke and traumatic brain injury. Our in vivo and in vitro data support that APOE4-associated brain endothelial cell (BEC) dysfunction contributes to cognitive deficits in models of aging and Alzheimer's disease. Therefore, our goal is to develop our in vitro models (R61 Phase) and conduct iterative screening (R33 phase) to identify novel compounds that ameliorate APOE4-associated BEC deficits.

PI_NAMEs: TAI, LEON MAING (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Address;Adult;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;assay development;Behavioral;Benchmarking;Biological;Biological Assay;Blood - brain barrier anatomy;Brain;brain endothelial cell;Cell Physiology;Cell Separation;Cells;Cerebral endothelium;Characteristics;Classification;Clinical;clinical application;Clinical Research;clinically relevant;Cognitive deficits;Complex;Data;dementia risk;Disease;Dose;Electrical Resistance;endothelial dysfunction;Endothelium;Environment;Evaluation;experimental study;extend lifespan;Functional disorder;genetic risk factor;Genotype;Goals;Impaired cognition;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo Model;Inferior;Inflammation;Inflammation Process;Inflammatory;Libraries;Link;Lipopolysaccharides;Location;Measures;Mind;Modeling;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neuronal Dysfunction;Neurons;new therapeutic target;novel;older adult;Pathway interactions;Peripheral;Permeability;Phase;Phenotype;Plasma;pre-clinical;Predisposition;protein protein interaction;Proteins;Protocols documentation;Public Health;repaired;response;Risk;Risk Factors;Role;Safety;screening;Signal Transduction;Standardization;Stimulus;Stroke;Supporting Cell;Testing;therapeutic target;Toxic effect;Toxin;Traumatic Brain Injury;Vascular Dementia

PROJECT_TITLE: Identifying compounds that target APOE4 associated brain endothelial dysfunction

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This project empowers families living with HIV in rural Kenya to address a range of factors contributing to ill- health: poverty, food insecurity, family dysfunction, social exclusion, family violence, and barriers to ART adherence. The project includes a planning year, three implementation years and one evaluation year to best prepare for an expanded R01 project. In addition to the research project, I will receive critical mentored research experience, gathering practical and theoretical knowledge to prepare for an independent research career.

PI_NAMEs: GOODMAN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;Africa South of the Sahara;Anxiety;Area;Behavioral;behavioral health;Businesses;care outcomes;career;career development;Caregivers;Caring;Child;Chronic Disease;Clinic;Clinical;clinical care;Clinical Data;cohort;Communities;community clinic;community empowerment;community intervention;community reintegration;Comprehension;cost;Data;Data Analyses;design;Development;Disease;early childhood;Economics;Elements;empowerment;Epidemiologic Research Design;epidemiology study;Evaluation;expectation;experience;Family;family building;Family Violence;follow-up;food insecurity;food security;Functional disorder;Funding;Future;Goals;Grant;Group Interviews;Health;Health behavior;health care delivery;health determinants;HIV;HIV-infected adolescents;Household;implementation science;improved;Income;informant;insight;Intervention;intervention mapping;Intervention Studies;Kenya;Knowledge;Learning;Low income;Maternal and Child Health;meetings;member;Mental Depression;Mental Health;Mentors;Mentorship;migration;Modeling;novel;Orphan;Outcome;Participant;Patient Recruitments;Patient Self-Report;Patients;Persons;Population;Population Intervention;post intervention;post-traumatic stress;Post-Traumatic Stress Disorders;Poverty;prevent;Problem Solving;Process;Production;programs;Provider;Psyche structure;psychologic;Psychometrics;psychosocial;Public Health;randomized trial;Reading;Recommendation;Research;Research Personnel;Research Project Grants;Rural;Savings;School Enrollments;skills;social;social capital;social epidemiology;social exclusion;Social support;Socioeconomic Factors;Source;Statistical Data Interpretation;Street Child;Support Groups;symposium;synergism;Testing;therapy design;therapy development;Training;Trust;Tuberculosis;United States National Institutes of Health;Violence;violence prevention;Viral;Viral Load result;viral transmission;vulnerable adolescent

PROJECT_TITLE: Strengthening Families Living with HIV in Kenya

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

PHR: Project Narrative In many neurodevelopmental disorders, including autism and Fragile X Syndrome (FXS), changes in molecular pathways underlie synaptic dysfunction and aberrant neuronal communication. This project identifies and characterizes a molecular signaling pathway in astrocytes that mediates FXS pathogenesis and has implications for neuron and astrocyte maturation in health and disease.

PI_NAMEs: DENG, JAMES DERONG (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Affect;Astrocytes;audiogenic seizure;autism spectrum disorder;Behavior;behavioral phenotyping;Biological;Biological Assay;Biotin;BMP6 gene;Bone Morphogenetic Proteins;Brain;career;cell type;Clinical;Clinical Trials;cofilin;Collaborations;Communication;Communities;Data;Defect;deficit syndrome;Dendritic Spines;Dependovirus;Disease;Down-Regulation;drug development;Electrophysiology (science);Endoplasmic Reticulum;Environment;Equipment;Exhibits;experience;experimental study;Failure;FMR1 gene;Foundations;Fragile X Syndrome;Functional disorder;Future;Gene Expression;Gene Silencing;Genetic;Genetic Transcription;Goals;Health;Homeostasis;Human;In Vitro;in vivo;Inherited;insight;Instruction;Intellectual functioning disability;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Laboratories;Ligase;LIMK1 gene;loss of function;LoxP-flanked allele;Mediating;Mediator;Mentorship;Messenger RNA;Modeling;Molecular;Molecular Neurobiology;Morbidity - disease rate;Morphology;Mus;Neurites;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neurons;neuropathology;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Physicians;Physiological;promoter;Protein Secretion;Proteins;Proteomics;Regulator Genes;Research;Research Training;Resources;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;small hairpin RNA;symptom treatment;Synapses;Testing;therapeutic target;therapy design;Training;Translating;Trinucleotide Repeat Expansion;Viral;Work

PROJECT_TITLE: The Role of Astrocyte BMP Signaling in Fragile X Syndrome


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Orphan Drug;Prevention;Rare Diseases;Transplantation

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The Northwestern University Data Analysis and Coordinating Center (NUDACC) will serve as a central leadership hub for the Liver Cirrhosis Network (LCN), coordinating all data-related and operational activities using cutting-edge resources for study design, planning and conduct, ongoing data monitoring and statistical analysis. NUDACC will work with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and LCN investigators to design (a) a robust, prospective observational cohort study of patients with cirrhosis, and (b) an adaptive, randomized, double-blinded, placebo-controlled trial investigating statin therapy for improvement in overall disease progression. NUDACC will harmonize all aspects of these studies, providing comprehensive oversight, management and administration; implementing state-of-the-art data coordinating; and harnessing methodological and collaborative statistical expertise.

PI_NAMEs: CIOLINO, JODY D. (contact);LADNER, DANIELA P

PROJECT_TERMS: absorption;Adrenergic beta-Antagonists;Alcohol dependence;Ascites;Biometry;Blood Vessels;Body Weight decreased;Budgets;Case Report Form;Cause of Death;Cell Physiology;central database;Charge;Chronic Hepatitis C;Cirrhosis;Clinical;clinical center;Clinical Trials Design;Coenzyme A;Collaborations;Communication;Compensation;Confusion;cost;curative treatments;Data;Data Analyses;Data Coordinating Center;data quality;design;Development;Disease;disease natural history;Disease Progression;double-blind placebo controlled trial;Endothelial Cells;Event;experience;Faculty;Fatigue;Fibrosis;gastrointestinal;Gastrointestinal Hemorrhage;Hemorrhage;Hepatic Encephalopathy;Human Resources;Icterus;Image;Impairment;improved;infection risk;Inflammation;innovation;Institutional Review Boards;Intervention;Investigation;Kidney;Laboratories;Lead;Leadership;Left;Life Style;Link;Liver;Liver Cirrhosis;Liver diseases;liver inflammation;liver transplantation;Longitudinal cohort;Malignant Neoplasms;Manuals;Medical;member;Meta-Analysis;method development;Methodology;mid-career faculty;Modification;Monitor;Morbidity - disease rate;mortality;Multi-site clinical study;Multicenter Studies;multiple data types;National Institute of Diabetes and Digestive and Kidney Diseases;nonalcoholic steatohepatitis;novel;nutrition;Obesity;observational cohort study;operation;Operative Surgical Procedures;Organ;Outcome;Oxidative Stress;Oxidoreductase;Patients;Positioning Attribute;prevent;Preventive Medicine;Primary carcinoma of the liver cells;professor;Prognosis;prospective;Prospective cohort;Proteins;Protocols documentation;Provider;Public Health;quality assurance;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Risk;Risk Reduction;Role;Safety;Sampling;Site;skills;Social Sciences;Statistical Data Interpretation;symptom treatment;Training;transplant centers;Transplantation;treatment strategy;United States;Universities;Work

PROJECT_TITLE: Liver Cirrhosis Network: Scientific and Data Coordination Center


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE HPV vaccines offer hope against HPV-associated cancers for both boys and girls; however, the rate of vaccination has not reached projected public health goals, and worsened significantly during the COVID-19 pandemic. This study will examine the feasibility and acceptability of an innovative game-based intervention designed for families of youth aged 11-14 to promote HPV vaccination; will explore changes in key outcomes and related measures; and will identify factors contributing to or impeding effective implementation in health clinic settings. The intervention and its approach have the potential to reduce health disparities in HPV- associated cancers in youth via low-cost technology and timely intervention.

PI_NAMEs: CHEN, ANGELA CHIA-CHEN  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Advocate;Age;aged;Agreement;American;Arizona;Behavior;Behavioral;behavioral outcome;boys;care providers;Child;Child health care;Clinic;Clinic Visits;Clinical;Collaborations;Communication;Computers;cost;COVID-19;COVID-19 pandemic;COVID-19 prevention;Data;Decision Making;design;Devices;Disease;Disparity;Dose;Drops;Economic Burden;Economics;Education;effective intervention;Effectiveness;Effectiveness of Interventions;efficacy evaluation;Eligibility Determination;Enrollment;expectation;Family;Feedback;Female;girls;Goals;group intervention;Health;health goals;health knowledge;Health Personnel;Healthcare;Healthcare Systems;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation intervention;Incidence;infection rate;innovation;innovative technologies;insight;Institution;Intervention;Interview;Job loss;Knowledge;Knowledge acquisition;Learning;Literature;longitudinal design;male;Malignant Neoplasms;Measures;Mediator;Methods;Mission;Modification;Morbidity - disease rate;mortality;novel;Outcome;pandemic disease;Parents;Participant;Patient Self-Report;pilot test;Play;post intervention;Preparation;Prevention;preventive intervention;Process;Provider;Public Health;Randomized;recruit;Reduce health disparities;Reporting;Research;response;Risk;Risk Factors;Science;Self Efficacy;sex;social;social cognitive theory;Structure;Tablets;Technology;Testing;theories;therapy design;Time;treatment as usual;Treatment Efficacy;United States National Institutes of Health;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;Vaccines;Video Games;videogame intervention;Visit;Youth

PROJECT_TITLE: Pilot Testing of a Game-Based Intervention to Promote HPV Vaccination in Families with Unvaccinated Children

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative: Cirrhosis, a major contributor to morbidity, mortality and utilization of public health resources, is increasing in the United States, with alcohol-associated and non-alcoholic fatty liver disease being the leading causes. Understanding the factors influencing progression of cirrhosis from different etiologies and the potential influence of therapeutics in mitigating progression of cirrhosis are necessary to achieving reductions in liver-related complications and mortality. The City of Angeles Clinical Center for Cirrhosis (CACC) will contribute a racial- ethnically diverse population to the multicenter NIDDK Cirrhosis Network to comprehensively evaluate factors, including social determinants, that are associated with cirrhosis progression versus regression and evaluate the safety and efficacy of statin therapy in compensated cirrhosis with clinically significant portal hypertension.

PI_NAMEs: STOLZ, ANDREW ABBA;TERRAULT, NORAH A. (contact)

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acculturation;Address;Adherence;Adult;Affect;Age;alcohol abstinence;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;Ancillary Study;Anti-viral Therapy;Ascites;Asian;Asian population;Attention;Behavior;biobank;Biological;Black Populations;Body Weight decreased;California;Cardiovascular system;Caring;Cause of Death;Cessation of life;Characteristics;Child;Chronic;chronic liver disease;Cirrhosis;Cities;Clinical;clinical center;Clinical Research;Clinical Trials;clinically significant;cohort;Cohort Studies;Collection;community setting;Compensation;contextual factors;County;Data;Development;Diabetes Mellitus;dietary;drug induced liver injury;Educational Status;effective therapy;efficacy evaluation;Endothelium;ethnic diversity;Etiology;Evaluation;Event;experience;Fibrosis;follow-up;Future;genetic variant;Goals;Health;health literacy;Health Resources;Healthcare;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatitis;Hepatitis B;Hepatitis C;Hepatotoxicity;Heterogeneity;Hispanic Populations;Human;Image;improved;improved outcome;Incidence;inflammatory modulation;inhibitor;Injury;Intervention Studies;Laboratories;Language;Life Style;Link;Liver;Liver diseases;liver injury;Longitudinal cohort;Los Angeles;Measures;Minority Groups;Modeling;Morbidity - disease rate;mortality;Multicenter Studies;multilevel analysis;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nature;Neighborhoods;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel drug class;Outcome;Participant;Pathway interactions;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;phase 3 study;Phospholipase;Physical activity;Placebo Control;Placebos;Population;Population Heterogeneity;Populations at Risk;Portal Hypertension;Poverty;prevent;Primary carcinoma of the liver cells;primary endpoint;Process;prospective;Prospective cohort;Proteins;Public Health;Questionnaires;racial diversity;racial population;Radiology Specialty;Randomized;Randomized, Controlled Trials;response;Risk;Risk Reduction;Role;rosuvastatin;Safety;safety net;sarcopenia;secondary endpoint;social;social determinants;social health determinants;sociodemographic factors;Specimen;Standardization;Subgroup;targeted treatment;Therapeutic;Therapeutic Intervention;translational study;transplant centers;treatment duration;trend;Underrepresented Minority;United States;Universities;Varicosity;Venous Pressure level;Viral hepatitis;Virus Diseases

PROJECT_TITLE: USC Cirrhosis Clinical Center


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Methods are available to measure all of the genes expressed by small numbers of cancer cells within tumors, but the approaches are very labor intensive and require considerable expertise. Dr. Wang has perfected and modernized these techniques over the past decade in the Unit directed by Dr. Kevin Janes to refine a skillset that is highly valued by the University of Virginia Cancer Center. R50 support will enable Dr. Wang to accelerate research progress within the Unit and collaborate to support additional cancer research on cancer- cell variability at the University of Virginia.

PI_NAMEs: WANG, LIXIN  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Acceleration;Acute;anti-cancer research;anti-cancer therapeutic;Award;Breast Epithelial Cells;Cancer Biology;cancer cell;Cells;Collaborations;Data;doctoral student;Ensure;epigenomics;erbB-2 Receptor;Genes;Heterogeneity;In Situ;in vivo evaluation;laser capture microdissection;Lead;Ligands;Malignant Neoplasms;Measures;Methods;Modernization;Molecular Cloning;Molecular Genetics;Monitor;Mus;pre-doctoral;Receptor Protein-Tyrosine Kinases;Research;Research Activity;Research Project Grants;Research Support;Scientist;skills;Solid Neoplasm;stem;Systems Biology;Techniques;Technology;three dimensional cell culture;Training;transcriptome sequencing;transcriptomic profiling;tumor;tumor initiation;U-Series Cooperative Agreements;Universities;University of Virginia Cancer Center;Variant;Virginia;Xenograft procedure

PROJECT_TITLE: Definition and perturbation of cell-regulatory heterogeneities in solid tumors


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: To develop effective preventative and therapeutic strategies it is vital that we define the cellular pathways and mechanisms that suppress diseases such as cancer. In this proposal we would determine how two small but potent proteins called SUMO and ubiquitin collaborate to orchestrate the cells' genome stability machinery, which includes DNA repair proteins. Vitally, apart from the much-needed fundamental knowledge we would gain, the SUMO and ubiquitin pathways offer therapeutic possibilities that our analyses would help exploit.

PI_NAMEs: BODDY, MICHAEL N (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Arsenic Trioxide;Binding;Biochemical;Biological;biophysical techniques;Cell Survival;Cells;Chromatin;cofactor;cohesin;Collaborations;combat;Complex;condensin;CRISPR/Cas technology;Data;Defect;Disease;Disparate;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;Environment;Eye;Genetic;genetic manipulation;genome integrity;Genome Stability;genotoxicity;Goals;Health;Homeostasis;insight;Knowledge;Label;leukemia;Malignant Neoplasms;Maps;Mediating;Mediator;Mutation;novel;Nuclear;Pathway interactions;Phase;Play;Process;Proteins;Proteome;Proteomics;recruit;Regulation;repaired;Research;response;Role;Signal Transduction;Site;spatiotemporal;Sumoylation Pathway;synergism;telomere;Telomere Pathway;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Toxic effect;Ubiquitin;ubiquitin-protein ligase;Virus Replication

PROJECT_TITLE: Defining Genome Stability Mechanisms and their Regulation by SUMO and Ubiquitin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Unfortunately, more than 20% of the critically ill children who require tracheal intubation suffer from adverse events. To reduce the adverse event risk, the bedside team performance should be optimized. We will transform the safety of pediatric tracheal intubation at 6 Pediatric ICUs by implementing a digitized Smart Checklist that has three specific features: prompts based on patient characteristics, direct display of difficult airway status and airway information, and high-risk warning based on predictive analytics.

PI_NAMEs: NISHISAKI, AKIRA  (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Smart checklist implementation for pediatric tracheal intubations in the ICU- multicenter study: SMART PICU

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The UC Davis Multidisciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America will offer a range of curricular, research, and career development activities to Latin American trainees with the goal of developing expertise in clinical cancer research and precision cancer medicine. This program will allow the trainees to implement and lead cutting-edge cancer research relevant for and in their home LMIC countries.

PI_NAMEs: CARVAJAL CARMONA, LUIS GUILLERMO (contact);FEJERMAN, LAURA

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Address;Age;American;anti-cancer research;Area;Basic Science;biobank;Bioinformatics;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer epidemiology;cancer genetics;cancer risk;cancer therapy;Cessation of life;Clinical;Clinical Oncology;cloud based;Collaborations;Colombia;Colombian;Country;Demography;Development;Educational Curriculum;Ethics;European;experience;Foundations;Funding;Funding Opportunities;Goals;graduate student;health care availability;Healthcare;Home;human capital;improved;Individual;individualized prevention;Infection Control;Institution;Knowledge;Latin America;Latin American;Latino Population;Lead;Life Expectancy;low and middle-income countries;Malignant Neoplasms;Mentors;multidisciplinary;Mutation;National Cancer Institute;Oncology;Patients;Peru;Peruvian;Physicians;Population;Postdoctoral Fellow;pre-clinical;precision cancer prevention;precision oncology;Precision therapeutics;Principal Investigator;programs;Provider;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Risk Assessment;Science;skills;Solid;tool;Training;Training Programs;United States National Institutes of Health;Universities

PROJECT_TITLE: UC Davis Multi-Disciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America.


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Natural Products;Nutrition;Physical Activity;Prevention;Rehabilitation

PHR: PROJECT NARRATIVE  Older people with lower extremity peripheral artery disease (PAD) have greater walking impairment and faster functional decline than those without PAD. Yet few therapies have been identified that improve disability in people with PAD. This randomized clinical trial will determine whether cocoa flavanols significantly improve walking impairment and/or prevent functional decline in older people with PAD, compared to placebo.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: 3-nitrotyrosine;actigraphy;Affect;Biopsy;Blood capillaries;brachial artery;Cacao Plant;Cell Nucleus;Chronic Disease;Clinical;Clinical Trials;Cocoa Powder;consumption measures;density;disability;Disabled Persons;Double-Blind Method;Flavanol;follow-up;functional decline;Functional impairment;Funding;Gait abnormality;human old age (65+);improved;improved mobility;Injury;Intervention;Intervention Studies;Ischemia;Isolated limb perfusion;Lower Extremity;Magnetic Resonance Imaging;Measures;Mediating;Mediation;meter;Mitochondria;mitochondrial dysfunction;Muscle;Muscle Mitochondria;Nitric Oxide;NOS3 gene;Older Population;Outcome;Oxidative Stress;Oxygen Consumption;Participant;Perfusion;Peripheral arterial disease;Persons;Phase;Phosphorylation;Physical activity;Pilot Projects;Placebos;Plasma;Population;pre-clinical;preclinical study;prevent;Property;Published Comment;Randomized;randomized trial;randomized, clinical trials;Reperfusion Therapy;response;Skeletal Muscle;Spirometry;Therapeutic;treadmill;Trees;Walking;walking performance

PROJECT_TITLE: COCOA flavanols to improve walking performance in PAD: the COCOA-PAD II Trial

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Patient Safety;Prevention;Rehabilitation;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Acute kidney injury (AKI) affects up to 20% of hospitalized patients and is associated with high rates of morbidity, poor quality of life, and death. Kidney care for patients with AKI after hospital discharge is often inadequate and fragmented. The goals of this proposal are to work collaboratively with the NIH to recruit adult patients with moderate to severe AKI ethically and safely to test interventions, including remote delivery AKI care bundles and cognitive behavioral based therapies by telehealth to improve clinical outcomes and outcomes most important to patients.

PI_NAMEs: NEYRA, JAVIER A.;SIEW, EDWARD D (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Absenteeism at work;Academic Medical Centers;acute care;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Alabama;Albuminuria;Aldosterone Antagonists;Ambulatory Care;Angiotensins;Attention;barrier to care;Behavioral;Blood Pressure;cardioprotection;Cardiovascular Diseases;caregiver education;Caring;Catchment Area;Cessation of life;Chronic Kidney Failure;Clinic Visits;Clinical;clinical center;Clinical Trials Design;Cognitive;Collaborations;Complication;Country;Couples;Creatinine;Data;design;Dialysis procedure;Disease Progression;Disparity population;Dose;Educational process of instructing;Electronic Health Record;Elements;Emergency department visit;Enrollment;Ensure;Ethics;Event;Exercise;experience;Face;Fatigue;follow-up;functional status;Glomerular Filtration Rate;Goals;Health;health related quality of life;Heart failure;high risk population;Home;hospital readmission;Hospitalization;Hospitals;Human;improved;improved outcome;Incidence;Individual;Infrastructure;injury recovery;innovation;Institution;Intervention;Investments;Kidney;Kidney Diseases;Longitudinal Studies;Measures;Medical center;medication safety;Medicine;Mental Depression;Minority Groups;modifiable risk;Modification;Monitor;Morbidity - disease rate;mortality;motivational enhancement therapy;multi-component intervention;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;nephrotoxicity;novel;novel strategies;Outcome;palliative;Patient Care;Patient Discharge;Patient Education;patient engagement;patient population;Patient-Centered Care;Patient-Focused Outcomes;Patients;Perception;Persons;Pharmaceutical Preparations;Physical activity;Physical therapy;Population;Population Heterogeneity;posthospitalization care;primary endpoint;primary outcome;Principal Investigator;Process;Proteinuria;Public Health;Quality of Care;Quality of life;Race;Randomized;randomized, clinical trials;Recovery;Recovery of Function;recruit;Recurrence;remote delivery;Renal function;Renin;Research;response;Risk;Risk Factors;Risk Reduction;secondary analysis;secondary endpoint;secondary outcome;Self Direction;Serum;SF-36;skills;socioeconomics;success;Survivors;symposium;Symptom Burden;Symptoms;telehealth;Telephone;Testing;transportation access;treatment as usual;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Southeastern Acute Kidney Injury (SEAK) Alliance for the COPE-AKI Consortium