PI_NAMEs: KLEINER, DAVID ERWIN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Autopsy;Brain;Cause of Death;Cessation of life;Chest;Clinical;clinical care;clinical center;clinical investigation;Clinical Investigator;Clinical Pathology;Clinical Protocols;Clinical Research;Collaborations;COVID-19 mortality;Cultured Tumor Cells;Databases;Demyelinating Diseases;Disease;Genetic;Goals;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Histology;Hospitals;Hour;Human;human tissue;immunodeficiency;Information Systems;Intramural Research Program;Investigation;Laboratories;Magnetic Resonance Imaging;Malignant Neoplasms;Mission;Multiple Sclerosis;National Institute of Mental Health;Nervous System Disorder;Non-Hematologic Malignancy;Normal tissue morphology;Pathologic;Pathology;Patient Care;Patients;Procedures;Process;programs;Protocols documentation;quality assurance;Reporting;Research;Research Personnel;Research Project Grants;Research Subjects;Research Support;Science;Services;Specimen;System;Text;Time;Tissues;tool;Training;treatment response;tumor;United States National Institutes of Health;urologic

PROJECT_TITLE: Postmortem Pathology


ACTIVITY: ZIC

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: CHINQUEE, JOSEPH  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Admission activity;Autopsy;Biopsy;Clinic;Clinical;clinical center;Consult;Consultations;COVID-19;Cytopathology;Data;Diagnosis;Diagnostic;Diagnostic Services;digital imaging;digital pathology;Dissection;Educational process of instructing;Evaluation;Growth;Hematopathology;Histology;Histopathology;human tissue;Immunohistochemistry;Infection;Laboratories;laboratory experience;laboratory experiment;Malignant Neoplasms;methylation testing;Microscope;Microscopic;Microscopy;Microtomy;Mission;molecular diagnostics;next generation sequencing;novel;Operative Surgical Procedures;Pathologist;Pathology;Patients;Preparation;Process;Protocols documentation;Reporting;Research;Research Activity;Research Personnel;Research Support;Rotation;Scanning;Slide;Specimen;Stains;Surgical Pathology;Techniques;tissue processing;Tissue Procurements;Tissues;Training;United States National Institutes of Health

PROJECT_TITLE: Histology Core Laboratory


PI_NAMEs: KRUHLAK, MICHAEL  (contact)

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Architecture;cancer stem cell;CCR;Cell Differentiation process;Cells;Chromatin;Communities;Core Facility;DNA Damage;Educational process of instructing;Elements;Endothelial Cells;Ewings sarcoma;fluorescence lifetime imaging;Image;Image Analysis;image processing;imaging software;Imaging Techniques;in vivo imaging;instrument;Interest Group;Licensing;light microscopy;Methodology;Methods;Microscope;microscopic imaging;Microscopy;Mitochondria;Monitor;Morphology;neoplastic cell;outreach;Protein Dynamics;Proteins;Publications;Reporter;Research;Research Personnel;response;Services;Site;stem cell growth;superresolution imaging;Techniques;Thymus Gland;Time;Training;two-photon;ultra high resolution;United States National Institutes of Health;Visualization

PROJECT_TITLE: CCR Microscopy Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

PI_NAMEs: HALAS, HYUNMI  (contact)

PROJECT_TERMS: Activated Lymphocyte;Address;Adoptive Cell Transfers;anti-cancer;Antigens;Area;Atypical lymphocyte;authority;Autologous;B lymphoid malignancy;Back;Biological Response Modifiers;Biopsy;Blood;Blood Component Removal;blood product;Blood specimen;cancer cell;Carcinoma;Cell Physiology;Cell Therapy;Cells;Characteristics;Cholangiocarcinoma;Clinical;clinical translation;Clinical Trials;Collection;Colorectal Cancer;Computer software;Core Facility;Cyclic GMP;Data;data curation;design;Development;Disseminated Malignant Neoplasm;Documentation;Effectiveness;Employee;Enrollment;Ensure;Environment;Equipment;Event;Excision;expiration;Extramural Activities;gene delivery system;Gene Modified;gene therapy;Generations;Genes;Goals;healthy volunteer;Human;Immunologics;Immunotherapy;improved;Industrialization;Industry;Infusion procedures;Institution;interest;Laboratories;Lymphocyte;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;manufacture;Manufactured Materials;Manufacturer;manufacturing facility;Melanoma;Mission;National Cancer Institute;neoantigens;Neoplasm Metastasis;novel therapeutics;operation;Operative Surgical Procedures;patient safety;Patients;Peripheral Blood Lymphocyte;Peripheral Blood Mononuclear Cell;Phase;prevent;Process;Production;programs;Protocols documentation;quality assurance;Quality Control;Quarantine;Reagent;receptor;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resected;Retroviral Vector;Sampling;screening;Serum;Services;Source;Specific qualifier value;success;Suspensions;synovial sarcoma;System;T cell therapy;T-Lymphocyte;targeted treatment;Testing;therapy development;Tissues;tool;Training;Translating;tumor;Tumor Antigens;tumor immunology;tumor infiltrating lymphocyte therapy;Tumor Tissue;Tumor-Associated Process;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Update;vector;Work

PROJECT_TITLE: Surgery Branch Cell Prep Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WISNIEWSKI, JAN  (contact)

PROJECT_TERMS: Biological Assay;Cells;Computer software;Contract Services;Core Facility;cost;design;digital imaging;Equipment;Event;Image;Image Analysis;image processing;Imaging Techniques;Immune system;Immunohistochemistry;Immunology;instrument;Laser Scanning Confocal Microscopy;Lasers;Microscope;microscopic imaging;Microscopy;Mission;new technology;novel;Procedures;quantitative imaging;Reagent;Research Personnel;Resolution;Scanning;Standardization;superresolution microscopy;System;Work

PROJECT_TITLE: EIB Microscopy Core Facility


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: MCKINNON, KATHERINE  (contact)

PROJECT_TERMS: biological research;CCR;Core Facility;Experimental Designs;Flow Cytometry;Goals;instrumentation;National Cancer Institute;NCI Center for Cancer Research;Research Project Grants;Techniques;Technology;Training;Vaccines

PROJECT_TITLE: CCR Vaccine Branch FACS Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: LAKE, ROSS  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;anti-cancer research;Basic Science;Brain;Brain region;Breast;Cancer Biology;cancer cell;cancer genetics;CCR;cell motility;Cells;Child;Circulation;Clinical Research;cohort;Colorectal;Communities;Confocal Microscopy;Core Facility;Differentiation Antigens;Distant;Embryo;empowerment;Epithelial Cells;Equipment;experimental study;fluorescence imaging;fluorescence microscope;gang;Genomics;Gleason Grade for Prostate Cancer;Glioblastoma;Goals;high resolution imaging;Human;Image;Image Analysis;imaging capabilities;Incubated;Indolent;instrument;interest;Label;Laboratories;Lasers;Lymph;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;Manuscripts;Measures;Microdissection;Microscope;Microscopy;Mission;Modeling;Molecular;Motor;Mus;Neoplasm Metastasis;novel therapeutic intervention;Optics;Organ;Ovarian;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;progression marker;Prostate;prostate cancer metastasis;Proteins;Radical Prostatectomy;real time model;Research;Research Personnel;residence;Resolution;Role;Scanning;Scientist;Signal Pathway;Signaling Molecule;Slide;Speed;Stains;stem-like cell;Stomach;Structure;summer student;Surveys;System;Techniques;three dimensional cell culture;Time;TNF gene;trafficking;transcriptomics;Tubular formation;tumor progression;Visualization;Xenograft Model;Zebrafish

PROJECT_TITLE: Laboratory of Cancer Biology and Genetics Microscopy Core Facility


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Skin Cancer;Women's Health Research

PI_NAMEs: ROBBINS, PAUL  (contact)

PROJECT_TERMS: Adoptive Immunotherapy;Adoptive Transfer;Algorithms;Antigen Presentation Pathway;Antigens;Atypical lymphocyte;Autologous;Autologous Tumor Cell;Autologous Tumor-Infiltrating Lymphocyte;Binding;Bioinformatics;Biological Assay;Biological Models;Breast Cancer Patient;cancer cell;cancer type;candidate identification;Carcinoma;Cell Line;Cell Separation;Cell surface;Cells;Cellular immunotherapy;Characteristics;Cholangiocarcinoma;Chromium;Clinical;Clinical Trials;clinically significant;Color;Colorectal Cancer;Colorectal Neoplasms;Copy Number Polymorphism;Core Facility;Cytotoxic T-Lymphocytes;Data;Differentiation Antigens;Disseminated Malignant Neoplasm;DNA;DNA analysis;DNA sequencing;DNA Sequencing Facility;driver mutation;Elements;Epitopes;Evaluation;Event;exome sequencing;experimental study;Expression Library;Family;fluorophore;Future;gene cloning;Gene Expression;Gene Fusion;Genes;Genetic Transcription;Helper-Inducer T-Lymphocyte;High-Throughput Nucleotide Sequencing;Histology;Human;immune function;Immunotherapy;immunotherapy trials;In complete remission;In Vitro;Individual;instrument;instrumentation;Investigation;KRAS2 gene;Lesion;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;melanocyte;Melanoma;Metastatic breast cancer;Monophenol Monooxygenase;Mus;mutant;Mutate;Mutation;Nature;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;Oncogenes;Operative Surgical Procedures;Organoids;overexpression;patient population;Patients;Peptides;peripheral blood;Phenotype;Population;Postdoctoral Fellow;Proteins;Quantitative Reverse Transcriptase PCR;Reagent;Recurrence;Renal Carcinoma;Research;Research Personnel;resistance mechanism;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;robotic system;Sampling;screening;Screening Result;Series;service member;Services;SILV gene;Somatic Mutation;Suspension Culture;T cell therapy;T-Cell Receptor;T-Lymphocyte;Testing;therapy resistant;tissue culture;tissue/cell culture;TP53 gene;transcriptome;transcriptome sequencing;tumor;Tumor Antigens;Tumor Escape;tumor progression;Tumor-Infiltrating Lymphocytes;Xenograft procedure

PROJECT_TITLE: DNA Sequencing and FACS Core Facilities


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Genetics;Lymphatic Research;Pediatric;Pediatric Cancer;Precision Medicine;Prostate Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

PI_NAMEs: SIMPSON, ROBERT  (contact)

PROJECT_TERMS: Adenocarcinoma;Agonist;androgen independent prostate cancer;Androgen Receptor;Animal Model;animal model development;anti-cancer research;Applied Research;Biological Markers;Biological Models;bioluminescence imaging;biomarker discovery;biomarker identification;Blood Vessels;cancer biomarkers;cancer cell;Cancer Model;cancer therapy;cancer type;carcinogenesis;Castration;cell behavior;Cells;Childhood;clinically relevant;Clonal Hematopoietic Stem Cell;Collection;Complex;Comprehension;design;Development;Diagnosis;Diagnostic;Diagnostic Neoplasm Staging;Disease;Dissociation;Endothelial Cells;Erythroid;Exhibits;Extracellular Signal Regulated Kinases;Focal Adhesions;genome editing;Genotype;Hematogenous;Hematopoietic stem cells;Heterogeneity;Histologic;Human;human disease;IL8 gene;Immunofluorescence Immunologic;Immunohistochemistry;improved;Informatics;Injections;insight;intravital microscopy;Invaded;Luciferases;Lung;lymph nodes;Lymphatic;lymphatic vessel;Malignant Neoplasms;Medical;Medicine;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methods;migration;Modeling;Molecular;molecular diagnostics;molecular pathology;Monitor;Mus;Muscle;Neoplasm Metastasis;Neuroendocrine Carcinoma;neutrophil;novel;novel therapeutics;Organ;Osteolytic;Pathogenesis;Pathologic;Pathology;patient derived xenograft model;PAX3 gene;personalized medicine;Phenotype;Phylogenetic Analysis;Population;preclinical trial;Prognosis;prostate cancer metastasis;prostate cancer model;protein expression;protein kinase C-delta;RB1 gene;Reagent;Relapse;Research;Residencies;Resistance;response;Rhabdomyosarcoma;RNA Splicing;Signal Transduction;Specific qualifier value;Stains;targeted treatment;Techniques;Technology;technology development;Testing;therapeutic development;Tissues;Tongue;tool;TP53 gene;Training;tumor;Tumor Cell Invasion;Validation;Variant;Xenograft procedure;Zebrafish

PROJECT_TITLE: Computational Pathology Research for Cancer Modeling, Diagnostics and Biomarkers


NIH_SPENDING_CATS: Bioengineering;Cancer;HIV/AIDS

PI_NAMEs: TARASOV, SERGEY  (contact)

PROJECT_TERMS: biomacromolecule;biophysical analysis;biophysical chemistry;Biophysics;Calorimetry;CCR;Circular Dichroism;Circular Dichroism Spectroscopy;Collaborations;Complex;computerized data processing;Consultations;cost effective;Data Analyses;design;Experimental Designs;experimental study;Fluorescence Spectroscopy;Fluorometry;Goals;HIV;Hour;instrument;instrumentation;Investigation;Laboratories;light scattering;liquid chromatography mass spectrometry;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Modernization;NCI Center for Cancer Research;operation;Photometry;Property;Protocols documentation;Research;Research Personnel;Resolution;Resources;Running;Scanning;Services;Spectrometry;Spectrum Analysis;structural biology;Structure;System;Technology;Time;time interval;Titrations;Training;United States National Institutes of Health;Walking

PROJECT_TITLE: CCR Biophysics Resource Core


PI_NAMEs: PALLIKKUTH, SANDEEP  (contact)

PROJECT_TERMS: Animals;Biochemical;Cancer Biology;cancer cell;Cells;Cellular biology;Chicago;clinical center;Color;Complex;confocal imaging;Confocal Microscopy;Core Facility;Data;Development;Experimental Designs;experimental study;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;fluorescence microscope;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Focal Adhesions;G Protein-Coupled Receptor Signaling;Goals;Human Resources;Image;Imaging Techniques;Imaging technology;instrument;intravital imaging;Kinetics;Laboratories;Laboratory Scientists;Lasers;Lateral;light microscopy;live cell imaging;Malignant Neoplasms;Medicine;meetings;member;Microscope;Microscopy;Molecular;Molecular and Cellular Biology;Molecular Biology;Morphogenesis;National Cancer Institute;new technology;Noise;Pathway interactions;Pattern;Pediatric Oncology;Photobleaching;Principal Investigator;Receptor Biology and Gene Expression;Regulation;Research;Research Personnel;Resolution;Resources;RNA;Role;Sampling;Scanning;Scientist;Signal Pathway;Signal Transduction;single molecule;Stains;stem cell fate;superresolution microscopy;System;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Training;ultra high resolution;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Confocal Core for the Laboratory of Cellular and Molecular Biology


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Patient Safety;Precision Medicine;Prevention

PI_NAMEs: HESELMEYER, KERSTIN  (contact)

PROJECT_TERMS: Aneuploidy;assay development;Biological Assay;Biological Markers;biomarker identification;Cancer Gene Mutation;cell free DNA;Chromosomes;clinical development;clinical investigation;Clinical Management;Clinical Trials;Collaborations;Development;Disease;Evaluation;Germ-Line Mutation;Goals;Immune response;Immunologic Monitoring;Investigation;Investigational Therapies;Knowledge;Laboratories;Malignant Neoplasms;Methods;Monitor;Mutation Analysis;nanopore;National Institute of Child Health and Human Development;new technology;novel;Pathogenicity;Patient Monitoring;patient safety;Patient Selection;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pregnant Women;prenatal testing;Process;Publishing;response;Sampling;Screening for cancer;Somatic Mutation;specific biomarkers;Technology;technology development;Test Result;Therapeutic;tumor;tumor DNA;Tumor Markers;Validation;Work

PROJECT_TITLE: Biomarker Investigations for Clinical Trials


PI_NAMEs: BEYER, RACHEL  (contact)

PROJECT_TERMS: Air;antigen-specific T cells;Autologous;cancer cell;Categories;cell bank;Cell Separation;Cells;cellular transduction;Clinic;Clinical;clinical lot;Colon Carcinoma;Core Facility;cost;Cyclic GMP;Dedications;Ensure;Environmental Monitoring;Epithelial Cells;Gene Delivery;Gene Modified;gene therapy;gene therapy clinical trial;Generations;Goals;Health care facility;Humidity;improved;Individual;individualized medicine;Interruption;Lentivirus Vector;Malignant Breast Neoplasm;Malignant neoplasm of lung;manufacture;Mechanics;Mediating;meetings;Metastatic Melanoma;Mutation;neoantigens;novel;novel strategies;Oncogenes;operation;Operative Surgical Procedures;Patients;Peripheral Blood Lymphocyte;Peripheral Blood Mononuclear Cell;pressure;Production;programs;Reagent;Research;Retroviral Vector;Risk;Schedule;Solid Neoplasm;Specific qualifier value;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Temperature;Testing;Time;trend;tumor;Tumor-Infiltrating Lymphocytes;vector;Viral;Viral Vector;Virus

PROJECT_TITLE: Clinical production of viral vectors for cancer gene therapy


NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: CAMPHAUSEN, KEVIN  (contact)

PROJECT_TERMS: Advanced Technology Center;Bioinformatics;Computing Methodologies;Core Facility;Data;Data Analyses;Development;Dose;Extramural Activities;Gene Mutation;innovation;Internet;machine learning method;Malignant Neoplasms;Methods;MMP9 gene;novel;protein biomarkers;Publishing;Quality Control;Radiation exposure;Radiation Oncology;Radiation-Sensitizing Agents;Research Personnel;response;Role;Services;Statistical Methods;synthetic lethal interaction;tool development;Training;tumor progression

PROJECT_TITLE: Radiation Oncology Branch - Microarray Facility


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: GULLEY, JAMES L. (contact)

PROJECT_TERMS: Acceleration;AIDS related cancer;anti-cancer research;Area;Basic Science;Bioinformatics;Biology;Budgets;Chemistry;Developmental Biology;Disease Progression;Disease susceptibility;drug discovery;Equipment;Genetic;Human Resources;Laboratories;Laboratory Research;Malignant Neoplasms;Molecular Target;NCI Center for Cancer Research;programs;Qualifying;Research;Research Personnel;Research Support;Resources;Retrovirology;RNA;Running;Scientist;structural biology;tool

PROJECT_TITLE: Basic Research Support for the CCR


PI_NAMEs: PARKHURST, MARIA  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoantigens;Autologous;Binding;cancer infiltrating T cells;Cell Separation;Cells;Clinical Protocols;Clinical Trials;Colon Carcinoma;Core Facility;Epitopes;exome sequencing;gene therapy clinical trial;genetically modified cells;Goals;Histology;Human;Immunology;Immunotherapy;In Vitro;individual patient;Lymphocyte Activation;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;Methods;Mutate;Mutation;National Cancer Institute;neoplastic cell;novel;objective response rate;Operative Surgical Procedures;Patients;Peptides;Population;Protocols documentation;Renal Carcinoma;Research Personnel;RNA;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;transcriptome sequencing;Transgenic Mice;tumor;Tumor Antigens;tumor immunology;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: The Antigen Targeting Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Kidney Disease;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: VOCKE, CATHY D (contact)

PROJECT_TERMS: accurate diagnosis;Adrenal Gland Neoplasms;Adrenal Mass;Affect;Aliquot;Ascites;Basic Science;bench to bedside;bevacizumab;Biological;Biopsy;Bladder;bladder surgery;Blood;Blood specimen;Body Fluids;cancer biomarkers;Cancer cell line;Cancer Gene Mutation;Cancer Patient;cancer type;Carbon Dioxide;Carcinoma;Caring;Cell Culture Techniques;cell immortalization;Cell Line;Cell Nucleus;Cellular Metabolic Process;central database;Chest;Clinical;clinical center;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Collection;Communication;Cyst Fluid;Data;Databases;Detection;Disease;DNA;DNA analysis;DNA Sequence Rearrangement;DNA sequencing;Dose;Electron Microscopy;Elements;Ensure;epidemiology study;Equipment and supply inventories;Erlotinib;exome;exome sequencing;extracellular;Family;Fluorescent in Situ Hybridization;Formalin;Freezing;gene discovery;Gene Expression;Genes;Genetic study;Genitourinary system;Genome;Genomics;Germ Lines;Glutaral;Goals;Heart;Hereditary Leiomyomatosis and Renal Cell Cancer;House mice;Human;Immunohistochemistry;Immunoprecipitation;Immunotherapy;Incubators;Inherited;Karyotype;Karyotype determination procedure;Kidney;Kidney Neoplasms;kidney surgery;Laboratories;Light;Liquid substance;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;metabolomics;Metastatic Neoplasm to Lymph Nodes;Methods;Methylation;Mitochondrial DNA;Molecular;Molecular Epidemiology;Molecular Target;molecular targeted therapies;Mus;Mutation;Mutation Analysis;new therapeutic target;next generation;Nitrogen;Northern Blotting;novel;Nuclear;Operative Surgical Procedures;Organelles;Other Genetics;Oxygen;Oxygen Consumption;Paper;Papillary;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pheochromocytoma;Plasma;Polymorphism Analysis;Predisposition;preservation;Privacy;Procedures;Process;prospective;Prostate;protein expression;Proteins;Proteomics;PSA level;Publishing;Reactive Oxygen Species;Reagent;Recording of previous events;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Research Personnel;Resources;RNA;Saliva;Sampling;Scientist;Secure;Security;Serum;Single Nucleotide Polymorphism;Site;Specimen;Sterility;Succinate Dehydrogenase;Surgical Pathology;Syndrome;Techniques;Testing;Therapeutic Agents;Time;Tissue Banks;tissue fixing;tissue processing;Tissue Sample;Tissues;transcriptome sequencing;Tuberous Sclerosis;tumor;Tumor Tissue;tumorigenesis;United States National Institutes of Health;Urine;Urogenital Cancer;Urologic Cancer;Urologic Oncology;Uterine Fibroids;VHL gene;Western Blotting;Whole Blood;whole genome;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Tissue Processing-Sequencing Facility


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Genetics;Hematology;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Skin Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: DU BOIS DE VROYLANDE, WENDY  (contact)

PROJECT_TERMS: Amendment;Animal Care and Use Committees;Animal Experimentation;Animal Genetics;Animal Model;Animals;anti-cancer research;B-Cell Lymphomas;Bioluminescence;Breeding;Cancer Biology;cancer genetics;cancer initiation;Cancer Model;Cell Line;Communities;Computer software;congenic;cost effective;design;DNA;Equipment;experimental study;Foundations;Genetic;Genetically Engineered Mouse;Genotype;Goals;imager;in vivo Model;Laboratories;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Melanoma;Monitor;mouse model;Multiple Myeloma;Mus;National Cancer Institute;Neoplasm Metastasis;new technology;Pharmaceutical Preparations;Plasma Cell Neoplasm;Plasma Cells;Preclinical Testing;Preparation;Research;Research Personnel;Research Support;Shipping;Skin Carcinogenesis;Techniques;Technology;tissue culture;tool;Transgenic Organisms;tumor;Tumor Bank;Tumor Cell Line;tumorigenesis;Writing

PROJECT_TITLE: Animal Model and Genotyping Core Support Facility


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PI_NAMEs: FILIE, ARMANDO  (contact)

PROJECT_TERMS: Anatomy;Ancillary Study;Breast;Cell Count;Cell Line;Central Nervous System;Clinical;Clinical Protocols;Clinical Research;COVID-19;Cytology;Cytopathology;Diagnosis;Diagnostic;Diagnostic Services;Duct (organ) structure;Evaluation;experience;Fellowship;Fine needle aspiration biopsy;Flow Cytometry;Goals;Gynecologic;human disease;immunocytochemistry;immunosuppressed;Investigation;Lavage;Malignant Neoplasms;Molecular;Molecular Analysis;Morphology;Nature;neoplastic cell;Organ;Organism;Pathologic;Pathology;patient population;Patients;Pericardial cavity;Peritoneal;Pleural;Prognosis;prognostic;Protocols documentation;Research;research study;Research Technics;Residencies;Respiratory System;RNA;Sampling;Specimen;System;Techniques;Technology;Testing;Therapeutic;Training;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;urogenital tract

PROJECT_TITLE: Cytopathology Core


NIH_SPENDING_CATS: Cancer

PI_NAMEs: DURELL, STEWART  (contact)

PROJECT_TERMS: ABCB1 gene;Adenosine;Alanine;ATP phosphohydrolase;Binding;Binding Sites;Biochemical;cancer therapy;Carrier Proteins;Cell surface;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Communication;comparative;Cryoelectron Microscopy;Data;design;Drug Efflux;Drug Transport;Effectiveness;Experimental Designs;experimental study;Goals;Human;Hydrolysis;Individual;Integral Membrane Protein;Knowledge;Maps;member;Membrane;Modeling;Molecular Conformation;molecular dynamics;molecular modeling;Multi-Drug Resistance;mutant;Mutation;Mutation Analysis;Nucleotides;Pathway interactions;Pharmaceutical Preparations;Proteins;Pump;Recovery;rhodamine 6G;Role;Site;small molecule;small molecule inhibitor;Structure;Structure-Activity Relationship;Substrate Interaction;Substrate Specificity;Testing;Transmembrane Domain;Trefoil Motif;tripolyphosphate;Tyrosine;Verapamil

PROJECT_TITLE: Molecular Modeling of the Human P-glycoprotein Transporter Protein


PROJECT_TERMS: Apoptosis;Binding;Biochemical Pathway;Biotinylation;Cancer Biology;Carbon;Cell Cycle Arrest;Cells;Cellular Stress;Chemicals;DNA Damage;drug development;Enzymes;gain of function;high throughput screening;In Vitro;Metabolic;Metabolism;Modification;molecular dynamics;molecular modeling;molecular targeted therapies;mutant;Normal Cell;Pattern;Post-Translational Protein Processing;Proteins;Proteome;Reaction;response;Signal Transduction;small molecule;structural biology;Sulfhydryl Compounds;TP53 gene;transcription factor;tumor;Work

PROJECT_TITLE: Molecular Modeling of Interactions Regulating the Activity of the p53 Protein


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetic Testing;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: XI, LIQIANG  (contact)

PROJECT_TERMS: American;Archives;B-Lymphocytes;Biological Assay;Biological Markers;Blood;Bone Marrow;BRAF gene;Cancer Patient;cancer subtypes;Capillary Electrophoresis;CCR;cell free DNA;Cells;Certification;Classification;Clinical;clinical center;clinical diagnosis;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;college;Complex;Consult;cost;Detection;Diagnostic;digital;Disease;DNA;Early Diagnosis;Eligibility Determination;exome sequencing;Gene Expression;Gene Mutation;Genes;Genomics;Hematologic Neoplasms;Hematopathology;Histiocytic sarcoma;Human Herpesvirus 4;Human Herpesvirus 8;Human T-lymphotropic virus 1;instrument;Intramural Research Program;Laboratories;Liquid substance;Lymphoproliferative Disorders;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Melanoma;Methylation;Modernization;Molecular;Molecular Biology;Molecular Diagnostic Testing;molecular diagnostics;molecular oncology;molecular pathology;molecular targeted therapies;multiplex assay;Mutation;Mutation Analysis;mutational status;National Cancer Institute;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Environmental Health Sciences;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Needle biopsy procedure;neoplastic cell;novel;Pathologic;Pathologist;Pathology;Patient Care Team;Patients;Pediatric Neoplasm;Performance;Play;Pleural;precision oncology;Process;prognostic;programs;Proteins;Quality Control;rare cancer;Reagent;Recurrence;Research;research clinical testing;Research Personnel;Rest;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Rotation;Running;Saliva;Sampling;Site;Specimen;Specimen Handling;Structure;Subgroup;symposium;T cell clonality;Technology;Test Result;Testing;Therapeutic;Tissues;Training and Education;transcriptome sequencing;Translational Research;treatment response;tumor behavior;tumor DNA;United States National Institutes of Health;virus related cancer

PROJECT_TITLE: Molecular Diagnostics Core Laboratory


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;HIV/AIDS;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: WANG, HAO-WEI  (contact)

PROJECT_TERMS: Biological Assay;Body Fluids;cancer cell;Cerebrospinal Fluid;Clinical;Detection;Diagnosis;Disease;Evaluation;Flow Cytometry;Goals;Hematopoietic Neoplasms;improved;leukemia/lymphoma;Liquid substance;Molecular Diagnosis;Morphology;Multicentric Angiofollicular Lymphoid Hyperplasia;Neoplasms;Patients;Pleural;primary effusion lymphoma;prognostic;Prognostic Factor;Protocols documentation;Techniques;Therapeutic;Therapeutic Intervention;Vitreous humor

PROJECT_TITLE: Flow cytometric detection of malignant cells in body fluids


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Gene Therapy;Genetics;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PROJECT_TERMS: Antibodies;Antibody Therapy;Antigens;B-Cell Lymphomas;Benign;Binding;Biological Assay;Biological Markers;biomarker evaluation;cancer cell;CAR T cell therapy;CCR;cell determination;Cell Surface Proteins;Characteristics;chimeric antigen receptor T cells;Development;Diagnosis;Disease;Evaluation;Flow Cytometry;Goals;HIV/AIDS;Human Herpesvirus 8;improved;insight;Lymphoma;Lymphoproliferative Disorders;Malignant Neoplasms;Medical;Monitor;Neoplasms;neoplastic cell;novel therapeutics;Pathway interactions;Patients;Play;primary effusion lymphoma;prognostication;rapid test;Research;Research Personnel;Resources;response;Role;System;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic evaluation;therapeutic target;Time;treatment response

PROJECT_TITLE: Flow cytometric evaluation of biomarkers


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: TELFORD, WILLIAM  (contact)

PROJECT_TERMS: Advisory Committees;Apoptosis;Azerbaijan;Biological Assay;CCR;Cell Separation;Cells;Core Facility;Cytometry;Data Analyses;Data Collection;design;Detection;Device or Instrument Development;Education;educational atmosphere;Educational workshop;experimental study;Faculty;Fiber;Flow Cytometry;Fluorescence-Activated Cell Sorting;Fluorescent Probes;high dimensionality;Home;Image Cytometry;Immunology;Immunophenotyping;indexing;Instruction;instrument;instrumentation;Interest Group;investigator training;Investments;Kazakhstan;Label;Laboratories;Lasers;lectures;Length;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of thorax;Measurement;Medicine;meetings;Meleagris gallopavo;member;Mission;new technology;novel;Optics;Pathology;Pediatric Oncology;Policies;Program Development;programs;Pump;research and development;Research Personnel;Research Project Grants;Resources;Running;Russia;Saudi Arabia;Schedule;Schools;Scientist;Services;Singapore;solid state;Sorting;stem cells;Students;Supervision;Techniques;Technology;telomere;Testing;theories;Time;Training;Transplantation;ultraviolet;United States National Institutes of Health;virtual;Visit;web site;Work

PROJECT_TITLE: FACS Core Facility


PROJECT_TITLE: Application of novel laser technology for flow cytometric analysis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: CARRELL, JEFFREY  (contact)

PROJECT_TERMS: Adhesions;Aging;Agreement;assay development;Binding;Biological Sciences;Biology;Bioluminescence;Cancer Biology;cancer genetics;CCR;CD8-Positive T-Lymphocytes;Cell Separation;Cell Therapy;Cells;Chemicals;chimeric antigen receptor T cells;Clinical Research;Colon;Computer software;Data Collection;Development;Developmental Biology;Division of Cancer Treatment and Diagnosis;E-Cadherin;Epithelium;Epitopes;Equipment;Evaluation;Female;Flow Cytometry;Functional disorder;Generations;glycogen synthase kinase 3 beta;Growth Factor;Hour;Human;Individual;innovation;insight;Institution;instrument;Interferon Type II;Interferons;investigator training;Laboratories;Life Cycle Stages;Luciferases;Macrophage;Maintenance;Malignant Neoplasms;mammary;mesothelin;Metastatic breast cancer;Microfluidics;Mouse Embryonic Stem Cells;Mus;National Institute of Allergy and Infectious Disease;operation;Organoids;Pathway interactions;Price;programs;PTGS2 gene;Publications;quality assurance;Reagent;reproductive;Research Personnel;Resistance;RNA;Sampling;Science;Scientist;Secure;Services;Signal Transduction;Sorting;spatiotemporal;structural biology;Students;symposium;System;Technology;tool;Training;tumor;Urologic Oncology;webinar;Work

PROJECT_TITLE: CCR-Frederick Flow Cytometry Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: OHUIGIN, COLM  (contact)

PROJECT_TERMS: Affect;Alleles;Anus;Area;Authorship;Autoimmune;Autoimmune Diseases;Autoimmunity;Bacteria;Bar Codes;Base Pairing;Base Sequence;Behavior;Binding;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biomass;cancer immunotherapy;Cancer Patient;cancer therapy;checkpoint inhibition;checkpoint therapy;Clinical;cloud platform;cohort;Cohort Studies;Communicable Diseases;Communication;Communities;comparative;Computer Analysis;Copy Number Polymorphism;cost effectiveness;Crohn's disease;Data;Data Storage and Retrieval;Disease;Disease Outcome;DNA;Drosophila genus;Epidemiology;fecal transplantation;Frequencies;fungus;Gene Amplification;Genes;Genetic;genetic analysis;Genetic Transcription;genome sequencing;Genomic approach;Genomics;Genotype;Goals;Graft Rejection;gut microbiota;Haplotypes;Health;Hepatitis C virus;Heterozygote;high throughput analysis;HIV;HLA Antigens;HLA-B Antigens;HLA-C Antigens;Human;Human Papillomavirus;Immune checkpoint inhibitor;Immunoglobulins;Immunologics;Infection;Inflammatory;Intestines;killer immunoglobulin-like receptor;Laboratories;Leukocytes;Libraries;Longitudinal Studies;Macaca;Malignant Neoplasms;Melanoma;Metabolic;Metabolic Pathway;metagenome;Metagenomics;Methodology;Methods;Microbe;microbial;microbial genome;Microbial Genome Sequencing;microbiome;microbiome analysis;microbiome components;microbiome research;microbiota;microbiota composition;Mission;Modification;Molecular Medicine;Mus;Nature;novel;Nucleic Acids;nutrition;Oral Characters;oral microbial community;Organism;Outcome;Paper;pathogen;Pathway Analysis;Pathway interactions;Patients;Pediatric Research;Peptides;Play;Population;Postbaccalaureate;Preparation;Process;Protocols documentation;Publications;Publishing;receptor;Reproducibility;Research;Research Personnel;response;Ribosomal RNA;Ribosomes;Risk;RNA;Robotics;Role;rRNA Genes;Running;Saliva;Sampling;Science;Scientist;Sequence Analysis;Shotguns;Source;Spectrum Analysis;Standardization;Statistical Data Interpretation;Students;Swab;System;Testing;Tissues;Transcript;transcriptomics;transplantation medicine;tumor;tumor immunology;United States National Institutes of Health;Vagina;Virus Diseases;whole genome;Work

PROJECT_TITLE: LICI Microbiome and Genetics Core


PI_NAMEs: TESSAROLLO, LINO  (contact)

PROJECT_TITLE: Gene Targeting Facility


PI_NAMEs: MALIK, MARIAM  (contact)

PROJECT_TERMS: anti-cancer research;Automation;Base Pairing;Bioinformatics;Biological Sciences;Cell Line;Cells;Collaborations;Collection;Communities;Complex;Computer software;cost;Data;Data Analyses;data archive;DNA;Ensure;Funding;Generations;genome editing;High-Throughput Nucleotide Sequencing;In Situ;Individual;Informatics;Journals;Laboratories;Metadata;Methods;Mission;Molecular;nanopore;National Institute of Allergy and Infectious Disease;NCI Center for Cancer Research;next generation sequencing;open source;Peer Review;Policies;Principal Investigator;Process;Production;programs;Protocols documentation;Publications;Reagent;Research;Research Personnel;Research Project Grants;Resources;RNA;Role;Sampling;Science;sequencing platform;Services;single cell analysis;single molecule;Software Tools;Standardization;Stretching;System;Technology;Testing;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Tumor Tissue;United States National Institutes of Health;Work

PROJECT_TITLE: CCR Sequencing Facility


PROJECT_TERMS: Active Sites;Binding;Cancerous;Catalysis;Catalytic Domain;CCR;cell growth;cell transformation;Development;DNA Damage;Enzymes;experimental study;Family;Genetic Transcription;Goals;inhibitor;innovation;insight;Ions;Kinetics;Laboratories;Magnesium;Malignant Neoplasms;molecular dynamics;Nitrogen;Oxygen;p38 Mitogen Activated Protein Kinase;Phosphoric Monoester Hydrolases;Phosphotransferases;PPM1D gene;protein phosphatase 2C;Proteins;Regulation;Roentgen Rays;Serine;Structure;Sulfur;Threonine;TP53 gene;Work

PROJECT_TITLE: Inhibitor Development Against the Wip1 Phosphatase


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: LIVAK, FERENC  (contact)

PROJECT_TERMS: 15 year old;20 year old;Advanced Malignant Neoplasm;Aerosols;Agreement;analytical tool;anti-cancer research;Area;Biological Assay;Biological Products;Breast Cancer Model;cancer stem cell;Cell fusion;Cell Separation;Cells;Chronic;Client;Complex;Computer software;Consultations;Consumption;Containment;Contract Services;Contracts;cost;Custom;Data Analyses;Dedications;design;detector;Development;diagnostic strategy;DNA analysis;DNA Damage;Education;Ensure;Equity;experience;experimental study;flexibility;Flow Cytometry;Fluorescence-Activated Cell Sorting;Fluorochrome;follow-up;Freezing;Funding;Future;Genetic;genome integrity;Goals;Hour;Housing;Image;Immune response;Individual;innovation;instrument;instrumentation;investigator training;Laboratories;Laboratory Personnel;Laboratory Research;Lasers;Lead;Leadership;Left;Lymphocyte;Maintenance;Malignant neoplasm of lung;Manufacturer;member;Mission;Modernization;NCI Center for Cancer Research;Neurons;new technology;novel;Occupations;operation;Periodicals;Phagocytosis;Policies;Positioning Attribute;pressure;Price;Procedures;Research Personnel;Research Support;Resource Sharing;Resources;response;Sampling;Schedule;Services;single cell analysis;Site;Sorting;Students;Supporting Cell;Technical Expertise;Technology;technology development;Testing;Time;Training;tumor;tumor diagnostic;United States National Institutes of Health;Universities;Virginia;Visit;Work

PROJECT_TITLE: CCR, LGI, Flow Cytometry Core


PI_NAMEs: JENKINS, LISA  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acetylation;Algorithms;American;Basic Science;Binding;Biological;Biological Assay;Biotechnology;Captopril;CCR;CDC2 gene;Cell Cycle Progression;Cells;Cellular biology;cellular oncology;Chickens;Clinical;Co-Immunoprecipitations;Collaborations;Colorectal Cancer;Communication;Communities;Complex;Computer software;crosslink;Cysteine;Data;Data Analyses;Databases;design;Deubiquitinating Enzyme;Development;Developmental Therapeutics Program;DNA Damage;DNA replication fork;Dose;Embryo;enzyme activity;Experimental Designs;experimental study;follow-up;Follow-Up Studies;Gene Silencing;Genetic;Genetic Transcription;genome integrity;genome-wide;genomic data;Histone Deacetylase Inhibitor;HIV;HIV Infections;Homeodomain Proteins;Homologous Gene;Hydrogen Sulfide;Inductively Coupled Plasma Mass Spectrometry;inhibitor;interest;Isotope Labeling;Journals;knock-down;Label;Laboratories;loss of function;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Maps;Mass Spectrum Analysis;Measures;member;Messenger RNA;Metals;Methods;Methylation;Methyltransferase;microorganism;Mitosis;Molecular;Molecular and Cellular Biology;mRNA Expression;mRNA Stability;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Nuclear;Nucleic Acids;Oncogenes;Oral;Outcome;overexpression;Paper;paralogous gene;phosphoproteomics;Phosphorylation Site;Post-Translational Protein Processing;Preparation;prevent;programs;protein aggregation;Protein Conformation;protein expression;Proteins;Proteolysis;Proteomics;Publishing;Rattus;recruit;Regulation;replication stress;Reporting;Research;Research Personnel;Resistance;Resources;RNA;RNA Stability;Running;S phase;Sampling;Signal Transduction;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;SN-38;Societies;Specificity;Sulfhydryl Compounds;Techniques;Technology;Testing;Therapeutic;thioester;Time;tool;Topoisomerase;Transcript;transcription factor;Translational Research;TRIM Gene;Tumor Suppressor Proteins;ubiquitin isopeptidase;Ubiquitination;United States National Institutes of Health;United States National Library of Medicine;Vaccines;web-based tool;Work;Zebrafish;Zinc

PROJECT_TITLE: CPTR - Mass Spectrometry Unit


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Nanotechnology;Rare Diseases

PI_NAMEs: KEDEI, NOEMI  (contact)

PROJECT_TERMS: Antibodies;Apoptosis;Atlases;Bar Codes;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;biomarker validation;Blood capillaries;Cancer Detection;cancer therapy;Canis familiaris;Capillary Electrophoresis;Cardiovascular Diseases;CCR;Cell Cycle;Cell Death;Cell Proliferation;Cells;Clinical;clinical application;clinical practice;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Colon Carcinoma;Communities;computerized data processing;Consumption;cost;cost estimate;cytokine;Data;Data Analyses;data infrastructure;data sharing;Data Storage and Retrieval;Detection;Development;digital;digital pathology;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;experimental study;extracellular;Fibroblasts;Fluorescent Antibody Technique;Freezing;Genes;Genomics;Human;Image;Image Analysis;imager;imaging modality;Imaging technology;Immune;Immunoassay;Immunofluorescence Immunologic;Immunologic Monitoring;Immunology;Immunooncology;improved;indexing;Individual;Industry Collaboration;Inflammation;innovative technologies;instrument;interest;Laboratories;Liver neoplasms;Lymphoid Tissue;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Measurement;Measures;Melanoma;Metabolic Diseases;Metastatic Neoplasm to the Lung;Methodology;Methods;Molecular;Molecular Profiling;Monitor;Morphology;multidisciplinary;Mus;Names;nanoimmunoassay;nanoscale;Neighborhoods;neoplastic cell;neurofibroma;Neurosciences;Optics;Organ;Osteosarcoma;ovarian neoplasm;Pathologist;Pathway interactions;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Plasma;Post-Translational Protein Processing;pre-clinical;preclinical study;Preparation;preservation;Program Development;Protein Analysis;protein biomarkers;Proteins;Protocols documentation;Publications;Publishing;Regulation;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;RNA;Running;Sample Size;Sampling;Science;Serum;Services;Signal Transduction;Signaling Molecule;Site;Slide;Specialist;Specimen;Stains;System;Technology;technology platform;therapeutic target;Tissue imaging;Tissue Microarray;Tissues;tool;Transcript;transcriptome;treatment response;tumor;tumor microenvironment;Tumor Tissue;United States National Institutes of Health;Update;Validation;Vendor;Walking;Western Blotting;Work

PROJECT_TITLE: Collaborative Protein Technology Resource - Nano-Scale Protein Analysis Section


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: REINHOLD, WILLIAM  (contact)

PROJECT_TERMS: Antibodies;anticancer activity;Antineoplastic Agents;Area;Binding;Bioinformatics;Cancer cell line;Cancer Patient;cancer site;Cancerous;Cell Line;Chemicals;Computer software;Data;data integration;Data Set;Databases;design;Development;Developmental Therapeutics Program;digital repositories;Discipline;Disparate;distributed data;drug discovery;drug sensitivity;Drug usage;Encyclopedias;Extramural Activities;General Hospitals;Generations;Genes;genetic variant;genomic data;Genomics;Goals;Graph;Image;improved;Individual;Informatics;insight;interest;Laboratories;Linear Regressions;Machine Learning;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Massachusetts;Metadata;Mining;Molecular;molecular scale;National Center for Advancing Translational Sciences;novel therapeutics;Output;Patients;Pattern;personalized cancer therapy;Persons;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Pharmacology;Phenotype;Predictive Factor;Protein Isoforms;quality assurance;repository;Research;Research Personnel;Resources;response;Sarcoma;Scientist;Series;Site;small cell lung carcinoma;Solid;Structure;System;therapy outcome;Time;tool;Training;Update;Validation;Variant;web app;web site;web-based tool

PROJECT_TITLE: Genomics and Bioinformatics Group web site development and maintenance


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Rare Diseases

PROJECT_TERMS: Adrenocortical Carcinoma;Almanacs;Area;bioinformatics resource;Cancer cell line;Cancerous;CCR;Cell Line;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;Databases;Development;Developmental Therapeutics Program;Disease;DNA copy number;drug sensitivity;Encyclopedias;Extramural Activities;Future;General Hospitals;Genes;Genetic;Genetic Transcription;genetic variant;Genomics;Goals;interest;Knock-out;Malignant Neoplasms;Manuscripts;Massachusetts;MicroRNAs;Molecular;multiple data sources;National Cancer Institute;National Cancer Program;neuroendocrine cancer;Oncologist;Output;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Protein Isoforms;Proteins;Publications;Publishing;Reporting;response;RNA;RNA Processing;RNA Splicing;Sampling;small cell lung carcinoma;Source;Standardization;The Cancer Genome Atlas;Tissues;tool;Transcript;treatment response;Variant;web app;Work

PROJECT_TITLE: RNA data development of cancer cell lines and patients


PROJECT_TERMS: Affective;Alkylating Agents;analytical method;Antineoplastic Agents;Biological;Bleomycin;Cancer Patient;cancer therapy;CDC2 gene;cell growth;Cell Line;Characteristics;Cladribine;Clinical;Clinical Data;Clinical Trials;Complex;Computational Technique;Computer software;Core-Binding Factor;Data;data integration;Databases;Disease;disorder subtype;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Repair;DNA Repair Gene;DNA Synthesis Inhibitors;drug action;Drug Compounding;Drug Targeting;EGFR gene;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;Erlotinib;Event;FDA approved;Gene Dosage;Genes;Genetic;genetic variant;genomic profiling;Genomics;Goals;infancy;inhibitor;Knowledge;Lead;leukemia;Linear Regressions;Machine Learning;Malignant Neoplasms;Manuscripts;mathematical learning;mathematical methods;Mathematics;MDM2 gene;Methodology;MicroRNAs;Molecular;Molecular Profiling;multiple datasets;mutational status;novel;Outcome;Output;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Protein Isoforms;PTEN gene;RAD52 gene;Ras/Raf;Resources;response;statistical learning;Structure;Subgroup;System;Techniques;Tissues;Topoisomerase;Topoisomerase-I Inhibitor;TP53 gene;Transcript;translational applications;Variant;Visualization;web app

PROJECT_TITLE: Comparison of molecular factors to drug activities


PI_NAMEs: SCHNEIDER, JOEL  (contact)

PROJECT_TITLE: Chemical Synthesis Group


NIH_SPENDING_CATS: Bioengineering;Cancer;HIV/AIDS;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Area;base;Bioinformatics;bioinformatics resource;Biological;biomedical informatics;CCR;Cloud Computing;Collaborations;Communities;comparative genomic hybridization;Computer software;Data Analyses;Data Correlations;data integration;data mining;Databases;Dedications;Ecosystem;experimental study;forging;Fostering;Goals;Hour;improved;Informatics;Information Technology;Infrastructure;Investments;Laboratories;Maps;mathematical analysis;member;Metadata;MicroRNAs;Modeling;next generation;next generation sequence data;operation;Outcome;Pathway interactions;Play;programs;Reporting;Reproducibility;Research;Research Personnel;Resources;Scientist;Sequence Analysis;Services;skills;Standardization;Statistical Data Interpretation;System;Time;Training;Training and Education;United States National Institutes of Health;Update;user-friendly;virtual

PROJECT_TITLE: CCR Collaborative Bioinformatics Resource


PI_NAMEs: WANG, YUN XING M (contact)

PROJECT_TERMS: beamline;Biological;CCR;Collaborations;Communities;Data;Data Analyses;doctoral student;Extramural Activities;Goals;International;Research;Research Personnel;Sampling;Science;Services;Technical Expertise;Training;tutoring;United States National Institutes of Health

PROJECT_TITLE: SAXS Core


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Genetics

PI_NAMEs: PEGORARO, GIANLUCA  (contact)

PROJECT_TERMS: aging related disease;anti-cancer research;Area;Basic Science;Biological;Biological Assay;Biology;Cells;Chromosomal Instability;Collection;computerized tools;Core Facility;design;DNA;DNA Damage;Epigenetic Process;Event;Extramural Activities;Gene Expression Regulation;Goals;Hormones;Image;imaging facilities;instrument;Intramural Research;Malignant Neoplasms;Microscopy;novel;Nuclear Translocation;Oligonucleotides;Pathway interactions;Phenotype;Population;Premature aging syndrome;quantitative imaging;Research Personnel;Resources;response;RNA Splicing;Running;Scientist;screening;Small Interfering RNA;tumor progression;United States National Institutes of Health

PROJECT_TITLE: HiTIF Microscopy Core Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Rare Diseases

PI_NAMEs: HALAS, HYUNMI  (contact)

PROJECT_TERMS: Activated Lymphocyte;Adoptive Cell Transfers;Aftercare;anti-cancer;Area;Atypical lymphocyte;B-Lymphocytes;Back;biobank;Biocompatible Materials;Biological;Biopsy;Blood;blood product;Blood specimen;Carcinoma;Cell Physiology;Cell Therapy;Cells;Characteristics;Cholangiocarcinoma;Clinical;Clinical Protocols;Clinical Trials;Code;Colorectal Cancer;Competence;Core Facility;Cyclic GMP;Disseminated Malignant Neoplasm;Effectiveness;Enrollment;Ensure;Environmental Monitoring;Equipment;Equipment and supply inventories;Event;follow-up;Gene Modified;gene therapy;Goals;HPV positive;Human;Human Resources;Immunologics;Immunotherapy;Infusion procedures;Institution;Laboratories;Location;Lymphocyte;lymphocyte product;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;manufacturing process;manufacturing run;meetings;Melanoma;member;Mission;National Cancer Institute;neoantigens;Neoplasms;novel therapeutics;Operative Surgical Procedures;participant enrollment;Patients;Peripheral Blood Lymphocyte;Phase;Production;programs;Protocols documentation;quality assurance;Quality Control;Regulation;Report (document);Reporting;Research;Research Personnel;Resected;Sampling;Services;Site;Specific qualifier value;Sterility;synovial sarcoma;T-Lymphocyte;Testing;Training;Training Programs;Translating;tumor;Tumor Antigens;tumor immunology;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Vendor

PROJECT_TITLE: Cell Production Core Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: KARPOVA, TATIANA  (contact)

PROJECT_TERMS: Address;Bayesian Analysis;Binding;Binding Sites;CCR;Cells;Chromatin;Chromosomes;Collaborations;Dependence;Development;DNA;DNA Sequence;Evaluation;Gene Expression Regulation;Genes;Genetic Transcription;Germany;Image;Imaging technology;Individual;Kinetics;Methods;Microscopy;Modeling;Population;promoter;Research;residence;Scientist;single molecule;Site;stem;Stress;System;Techniques;Time;transcription factor;Transcriptional Regulation;ultra high resolution;Universities;Yeast Model System;Yeasts

PROJECT_TITLE: Transcription factor mobility


PROJECT_TERMS: biophysical properties;CCR;Cellular biology;Collaborations;Comb animal structure;Consultations;Country;Custom;Education;Educational process of instructing;Ensure;Fluorescence Resonance Energy Transfer;Head;Image;innovation;instrument;instrumentation;Interest Group;Laboratories;Light;light microscopy;Lighting;Malignant Neoplasms;Microscope;Microscopy;Mission;nano;National Heart, Lung, and Blood Institute;Optics;outreach;Paper;Publications;Research;Research Personnel;Resolution;Running;single molecule;Techniques;Training;ultra high resolution;United States National Institutes of Health;Universities

PROJECT_TITLE: LRBGE Optical Microscopy Core


PI_NAMEs: WINKLER PICKETT, ROBIN  (contact)

PROJECT_TERMS: 3-Dimensional;anti-cancer research;archive data;Automation;Bioinformatics;Biological Assay;Cells;Cellular Assay;cellular imaging;Chromatin;collaboratory;Collection;Cryo-electron tomography;Cryoelectron Microscopy;data archive;Dedications;Development;Electron Microscopy;exome;expression cloning;Fluorescence Microscopy;gene panel;Genomics;High-Throughput Nucleotide Sequencing;HIV Infections;Image;Immune;Interdisciplinary Study;Ions;Laboratories;Light;light microscopy;Malignant Neoplasms;Mass Spectrum Analysis;metabolomics;Metadata;Metals;Methods;microscopic imaging;Microscopy;Molecular;molecular imaging;NCI Center for Cancer Research;new technology;next generation sequencing;novel;nucleic acid detection;Optics;Pathway interactions;Phosphopeptides;programs;protein expression;protein purification;Proteins;Proteomics;Reporting;Research;research facility;Research Personnel;Resources;Sample Size;Sampling;Scanning Electron Microscopy;Science;screening;Services;single cell analysis;single cell sequencing;Speed;Standardization;Structure;T-Lymphocyte;Techniques;Technology;Tissue Stains;Tissues;transcriptome sequencing;Transposase;two-photon;ultra high resolution;Validation;Visualization;Work

PROJECT_TITLE: CCR Dedicated Cores


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases;Urologic Diseases

PI_NAMEs: CONNER, ELIZABETH  (contact)

PROJECT_TERMS: 3-Dimensional;ATAC-seq;Atlases;Authorship;Award;bacterial genome sequencing;Biochemistry;Bioinformatics;bioinformatics resource;Biological;Biological Assay;Biological Sciences;Businesses;carcinogenesis;CCR;Cell Therapy;Cells;Cellular biology;cellular oncology;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;clinical center;Collaborations;Communities;Computer software;Computers;Consultations;Core Facility;cost;cost effective;CRISPR screen;Custom;Data;Data Analyses;Data Reporting;Data Science;design;Developmental Therapeutics Program;Dideoxy Chain Termination DNA Sequencing;digital;DNA;DNA purification;DNA Sequencing Facility;Educational workshop;Elements;Enzymes;Experimental Designs;Gene Expression;Genetic;Genitourinary system;genome analysis;genome integrity;Genomics;Grant;Head;Hi-C;HIV/AIDS;Hour;Human;Imaging technology;immunodeficiency;Immunology;Immunooncology;Individual;innovation;instrument;instrumentation;Interest Group;Laboratories;Learning;lectures;Libraries;Malignant lymphoid neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of thorax;Malignant Neoplasms;meetings;member;Messenger RNA;Methods;Mission;Molecular;Molecular Biology;molecular imaging;Molecular Profiling;Mus;nano-string;nanopore;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;Nature;neuro-oncology;next generation sequencing;oncology program;Operative Surgical Procedures;outreach;Paper;Pathology;Pediatric Oncology;Plasmids;Policies;Principal Investigator;Procedures;Process;Production;programs;Proteins;Proteomics;Provider;Quality Control;Radiation Oncology;Reaction;Receptor Biology and Gene Expression;Recovery;Reporting;Research;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA library;Running;Sampling;Schedule;Science;Scientist;seal;Secure;sequencing platform;Services;single cell analysis;single cell sequencing;single-cell RNA sequencing;Slide;Summary Reports;Surgical Oncology;System;Systems Analysis;Techniques;Technology;Technology Transfer;Thoracic Surgical Procedures;Time;Training;Training and Education;transcriptome;transcriptome sequencing;tumor immunology;United States National Institutes of Health;Urologic Oncology;Vaccines;Vendor;webinar;Woman;Work;working group

PROJECT_TITLE: CCR Genomics Core


NIH_SPENDING_CATS: Cancer;Coronaviruses

PI_NAMEs: HEWITT, STEPHEN  (contact)

PROJECT_TERMS: 3D Print;Autopsy;biomarker validation;Collaborations;COVID-19;COVID-19 mortality;Disease;DNA;Experimental Pathology;Goals;Histology;Image Analysis;Immunohistochemistry;In Situ Hybridization;Laboratories;laser capture microdissection;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;member;Methodology;Pathologist;Pathology;Publications;Publishing;Research;Research Personnel;Research Support;RNA;SARS-CoV-2 infection;Science;Services;Skin Cancer;Tissue Microarray;tool;United States National Institutes of Health;whole slide imaging

PROJECT_TITLE: Experimental Pathology Laboratory (EPL)


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: GILBERT, MARK  (contact)

PROJECT_TERMS: angiogenesis;Animal Experiments;Animal Model;Animals;anti-tumor agent;anti-tumor drug;Area;Biological;Biological Markers;Biological Process;Biology;Biopsy;Biotechnology;blood-brain barrier disruption;Brain Neoplasms;Breeding;Camptothecin-11;Cancer cell line;cancer stem cell;Categories;Cell Line;Cells;Central Nervous System Neoplasms;Characteristics;Clinic;Clinical;clinical center;clinical development;Clinical Drug Development;Clinical Investigator;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Convection;Cooperative Research and Development Agreement;Cytostatics;cytotoxic;Data;design;Development;Developmental Therapeutics Program;Diagnostic;Dose;Drug Delivery Systems;Drug Screening;Drug Targeting;early phase clinical trial;endothelial stem cell;Evaluation;expectation;experimental study;Extramural Activities;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;Genomics;Glioma;glioma cell line;Growth;Human;human disease;Image;imaging science;Immunotherapeutic agent;In Vitro;in vivo;Institution;Intracarotid;Investigational Therapies;irinotecan;Label;Laboratories;Magnetic Resonance Imaging;Magnetism;Metabolic;Methods;Mission;Modeling;Molecular;mouse model;Mus;National Institute of Neurological Disorders and Stroke;neural;novel;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;pre-clinical;precision medicine;preclinical development;Program Development;programs;Progression-Free Survivals;Property;Protective Agents;protein biomarkers;Radiation-Sensitizing Agents;Reagent;repository;Research;Research Design;research facility;Research Personnel;Resources;response;RNA;Sampling;Schedule;screening;screening program;Serum;Serum Markers;Services;Specimen;stem cell biology;stem cells;subcutaneous;Surrogate Markers;targeted treatment;Technology;Testing;Therapeutic;Tissues;Translational Research;translational study;tumor;Tumor Cell Line;tumor progression;Tumor Stem Cells;United States National Institutes of Health;vasculogenesis;Work;Xenograft procedure

PROJECT_TITLE: Pre-clinical Translational Research Facility


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: CHINQUEE, JOSEPH  (contact)

PROJECT_TERMS: Accreditation;American;Anatomy;biobank;Cancer Center;Clinical;clinical center;Collaborations;Collection;college;Complex;Consult;data resource;Databases;demographics;Diagnosis;Diagnostic;Freezing;Frozen Sections;Genetic Materials;Goals;Histology;Human;Journals;Laboratories;laboratory facility;Medical center;meetings;Military Personnel;Operating Rooms;operation;Pathologist;Pathology;Patients;Peer Review;preservation;Primary Neoplasm;Process;programs;Protocols documentation;Publications;repository;Research;Research Personnel;Research Support;Services;Slide;Specimen;Stains;standard of care;Standardization;Surgical Pathology;System;Time;Tissue Banks;Tissue Preservation;tissue processing;Tissue Procurements;tissue resource;Tissues;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Tissue Procurement, Processing Facility and Biorepository


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PROJECT_TERMS: Adrenocortical Carcinoma;Almanacs;Area;bioinformatics resource;Cancer cell line;Cancerous;CCR;Cell Line;Cell Survival;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Databases;Development;Developmental Therapeutics Program;Disease;DNA;DNA copy number;DNA Methylation;DNA Sequence Alteration;drug sensitivity;Electronic Mail;Encyclopedias;Extramural Activities;Future;General Hospitals;Genes;Genetic;Genetic Transcription;genetic variant;Genomics;Goals;interest;Knock-out;Malignant Neoplasms;Manuscripts;Massachusetts;Methylation;MicroRNAs;Molecular;multiple data sources;Mutation;National Cancer Institute;National Cancer Program;neuroendocrine cancer;Oncologist;Output;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Proteins;Publications;Publishing;Reporting;response;Sampling;Site;small cell lung carcinoma;Source;Standardization;System;The Cancer Genome Atlas;Tissues;tool development;Transcript;treatment response;web app;whole genome;Work

PROJECT_TITLE: DNA data development for cancer cell lines and patients


PI_NAMEs: MATSUO, HIROSHI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antagonist;APOCEC3G gene;Biochemical;cancer cell;Complex;Cryoelectron Microscopy;Development;DNA;Genes;Goals;HIV Genome;HIV-1;HIV/AIDS;Human;Infection;inhibitor;insight;Macromolecular Complexes;Malignant Neoplasms;Mutate;Mutation;novel therapeutics;Nuclear Magnetic Resonance;Oligonucleotides;protein structure;Proteins;Research Project Grants;RNA;Structure;Techniques;vif Gene Products;X-Ray Crystallography

PROJECT_TITLE: Structural studies of biomolecules related to cancer and HIV-AIDS


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases

PI_NAMEs: HO, MITCHELL  (contact)

PROJECT_TERMS: Address;Africa;anti-cancer research;Antibodies;antibody engineering;Antibody Formation;antibody libraries;Antibody Therapy;Antibody-drug conjugates;Antigen Targeting;Antigens;Apical;Area;Award;Bacteriophages;Binding;Binding Proteins;biothreat;Bispecific Antibodies;Camels;cancer cell;cancer therapy;Cell Surface Receptors;Cells;Cellular biology;checkpoint inhibition;chimeric antigen receptor T cells;clinical application;Collaborations;Communicable Diseases;Communication;Communities;Complex;Cryoelectron Microscopy;cytotoxic;design;Development;Epitopes;Eukaryotic Cell;Exhibits;Glycoproteins;Glypican;GP2 gene;GPC3 gene;GTPBP1 gene;Hepatology;Human;human disease;Immunoglobulin G;Immunotoxins;improved;inhibiting antibody;innovation;insight;Intramural Research;Intramural Research Program;Ion Channel;Laboratories;Laboratory Research;Lassa virus;Libraries;Ligand Binding;Malignant Neoplasms;member;mesothelin;Molecular Biology;Mus;Names;nanobodies;National Cancer Institute;Nature;NCI Center for Cancer Research;neutralizing antibody;new technology;Normal Cell;novel;pandemic disease;Paper;Patients;Phage Display;Play;programs;Prokaryotic Cells;Property;Proteins;Protomer;Publishing;Research;Research Personnel;Resources;response;Role;Scientist;Services;Shark;Signal Transduction;Site;Specificity;T-Cell Activation;T-Lymphocyte;targeted treatment;Technology;technology development;Therapeutic;Therapeutic antibodies;Therapeutic Index;Therapeutic Uses;Toxic effect;Training;United States National Institutes of Health;Virus;Virus Diseases

PROJECT_TITLE: Antibody Engineering Program


PI_NAMEs: CALZONE, KATHLEEN  (contact)

PROJECT_TERMS: Address;Administrator;Adopted;Affect;Agreement;Annual Reports;CCR;Cell Line;Certification;Charge;Clinical;Clinical Investigator;Clinical Protocols;Code;Complex;Computer software;Computers;Cooperative Research and Development Agreement;Data;data handling;data integration;data management;data portal;data preservation;data sharing;data sharing networks;data standards;data submission;database of Genotypes and Phenotypes;Development;Disease;Electronic Mail;Elements;Ensure;experience;Feedback;Funding;Future;genomic data;Genomics;Hand;Home;Human;Individual;Informed Consent;Infrastructure;Institution;Intramural Research Program;Laboratory Scientists;Language;Lead;Learning;Link;Malignant Neoplasms;Manuals;Mediation;meetings;Modification;Names;Notification;Online Systems;Organism;Participant;payment;Performance;Persons;Policies;Policy Developments;Positioning Attribute;Procedures;Process;programs;Protocols documentation;Rare Diseases;Recommendation;Records;Reporting;Research;Research Personnel;Resources;Review Committee;Science Policy;Services;Source;Specific qualifier value;statistics;Supervision;System;Time;Time Study;timeline;tool;Transfer Agreement;United States;United States National Institutes of Health;Update;waiver;web site;wiki;Work;working group

PROJECT_TITLE: Genomic Data Sharing


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Ovarian Cancer;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: CROOKS, DANIEL  (contact)

PROJECT_TERMS: 3-Dimensional;Bacteria;Biochemical;Biological;Biological Assay;Biological Markers;Blood;Brain Neoplasms;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Model;cancer prevention;cancer recurrence;cancer therapy;Carbon;Carcinogenesis Mechanism;Cell Line;Cells;Chemicals;chimeric antigen receptor T cells;Citric Acid Cycle;clinically relevant;cohort;Collaborations;Custom;Data Analyses;Detection;Development;Glioma;Goals;Human;Immune system;Infusion procedures;inhibitor;Investments;Ions;Magnetic Resonance Spectroscopy;Malignant neoplasm of ovary;Mammals;Manuscripts;Mass Chromatography;Mass Spectrum Analysis;Measures;member;Mentors;Metabolic;Metabolism;metabolome;metabolomics;Methods;Modification;Monitor;mutant;NADH;NADP;neoplastic cell;Neuroblastoma;neuroblastoma cell;new therapeutic target;Nicotinamide adenine dinucleotide;NMR Spectroscopy;novel;novel strategies;novel therapeutics;Nuclear;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Physiologic pulse;Plants;pre-clinical;Preparation;Procedures;Proliferating;pyridine nucleotide;Resolution;Sampling;small molecule;spectroscopic imaging;stable isotope;Therapeutic Agents;Therapeutic Intervention;Time;Tissues;Toxic effect;Tracer;tumor;Tumor Cell Line;tumor metabolism;Tumor Tissue;Tumor-Derived;Urine

PROJECT_TITLE: Metabolomics Core


NIH_SPENDING_CATS: Cancer;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lung;Lung Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases;Vaccine Related

PI_NAMEs: GULLEY, JAMES L. (contact)

PROJECT_TERMS: Basic Science;cancer therapy;CCR;Clinical Research;Hematopoietic Neoplasms;HIV vaccine;Immune system;Immunotherapy;Laboratory Research;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Lung;Mission;Modeling;Mus;Neoplasm Metastasis;Neuroblastoma;Osteosarcoma;Pediatric Neoplasm;Pharmaceutical Preparations;Pharmacology Study;Principal Investigator;Resources;Solid Neoplasm;Testing;Therapeutic;Translating;Translations

PROJECT_TITLE: Office of Translational Resources


PI_NAMEs: KETTENHOFEN, CHRISTINE  (contact)

PROJECT_TERMS: Acceleration;Address;AGFG1 gene;anti-cancer research;antibody conjugate;Antibody-drug conjugates;Antineoplastic Agents;Artificial Intelligence;Award;Behavior;Biochemical;Biological;Biological Assay;Biological Models;Biology;biomarker identification;BRAF gene;Breeding;cancer cell;Cardiac Edema;CCR;cell motility;Cell Survival;Cells;Cellular Structures;Chemicals;Chemistry;Childhood Melanoma;Cilia;ciliopathy;cilium biogenesis;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Color;Communication;convergent extension;Costello syndrome;CRISPR/Cas technology;Defect;design;Development;developmental disease;Disease;disease model;Division of Cancer Epidemiology and Genetics;DUSP6 protein;Effectiveness;egg;Embryo;Equipment;Evaluation;Event;experimental study;Extramural Activities;Failure;fluorophore;Funding;Future;Gene Transfer Techniques;Generations;Genes;Genetic;genetic approach;genetic manipulation;Germ Lines;Germ-Line Mutation;Goals;Human;human disease;Hypertrophic Cardiomyopathy;Image;imaging capabilities;improved;in vivo;in vivo imaging;in vivo optical imaging;Injections;insight;Investigation;knock-down;knockout gene;Label;Laboratories;Link;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;MAP Kinase Gene;Measurement;Mechanics;Medical Genetics;Melanoma;Membrane;Membrane Fusion;Methods;Mission;model organism;Modeling;Molecular;Monitor;Monoclonal Antibodies;mutant;Mutation;Nature;neoplastic cell;Neurodegenerative Disorders;novel;novel therapeutics;optical imaging;Orthologous Gene;Outcome;overexpression;Pathway interactions;Patients;Pediatric Oncology;Pharmacotherapy;Phenotype;Preparation;Process;Productivity;Property;protein expression;Protein Overexpression;Proteins;Publishing;Ras/Raf;Regulation;Reporter;Reporting;Research;Research Personnel;Resources;reverse genetics;RNA;Role;Severities;Signal Pathway;Signal Transduction;Structure;Subcellular structure;System;targeted agent;targeted treatment;Technical Expertise;Technology;Testing;Therapeutic;Therapeutic Agents;Time;timeline;tool;Toxic effect;trafficking;Training;transgene expression;Transgenic Organisms;tumor;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;uptake;Variant;variant of interest;variant of unknown significance;Vertebrates;Visualization;Work;Xenograft procedure;Zebrafish;zebrafish development

PROJECT_TITLE: Zebrafish core


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SCHNEEKLOTH, JOHN  (contact)

PROJECT_TERMS: Acceleration;Animals;anti-cancer;Antineoplastic Agents;Basic Science;Biology;biophysical analysis;CCR;Chemicals;Data Analyses;drug candidate;Goals;In Vitro;in vivo;interest;Laboratories;Lead;lead optimization;lead series;Legal patent;Mission;novel;Organic Chemistry;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;pre-clinical;preclinical development;Research Personnel;Resources;Risk;screening;screening panel;small molecule;Source;structural biology;Technology;Toxic effect;Translations

PROJECT_TITLE: Medicinal Chemistry Accelerator


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Neuroblastoma;Neurosciences;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: LASSOUED, WIEM  (contact)

PROJECT_TERMS: Aftercare;androgen independent prostate cancer;anti-PD-1;Antibodies;Autopsy;B-Lymphocytes;Benign;Biology;Biopsy;Brachyury protein;Brain;cancer cell;cancer immunotherapy;Cancer Patient;Castrate sensitive prostate cancer;CD19 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Density;Cell Line;Cells;chemotherapy;Chordoma;Cisplatin;Clinical;Collaborations;Combination immunotherapy;Complex;Comprehensive Cancer Center;Cooperative Research and Development Agreement;CT26;CXCL13 gene;cytokine;Cytoplasm;cytotoxic;cytotoxic CD8 T cells;Dendritic Cells;Development;Disease Outcome;Drops;Enrollment;Equilibrium;FCGR3B gene;first-in-human;Fluorescent Antibody Technique;Foundations;FOXP3 gene;Frequencies;Funding;Gene Modified;Genetic Transcription;Grant;Granzyme;HLA-DR Antigens;Hospitals;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunologics;Immunooncology;Immunotherapeutic agent;indexing;insight;Institution;interest;Interleukin-12;ITGAM gene;ITGAX gene;Laboratories;London;Lymphocyte;machine learning method;Macrophage;malignant mouth neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;mast cell;Mediating;medical schools;Medical Students;meetings;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Molecular;Mus;Myeloid-derived suppressor cells;Natural Killer Cells;Nature;NCAM1 gene;neoplasm immunotherapy;neoplastic cell;Nivolumab;Normal tissue morphology;novel;Olfactory Neuroblastoma;Pathology;patient response;Patients;pericardial sac;Phase II Clinical Trials;Pituitary Gland;Play;posters;pre-clinical;Preparation;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;protein expression;Proto-Oncogene Protein c-kit;Protocols documentation;PTPRC gene;Publishing;Quality of life;Radical Prostatectomy;Regulatory T-Lymphocyte;Research;Resistance;response;RNA;Role;Safety;Sampling;Sampling Studies;Scanning;Signal Transduction;Site;Source;Spinal Cord;Stains;stem;Students;Synaptophysin;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;tertiary lymphoid organ;Testing;therapeutic vaccine;Tissue Sample;Tissues;Training;translational study;Tryptase;tumor;tumor growth;tumor progression;Tumor Tissue;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Universities;Validation;vector;Woman;Work

PROJECT_TITLE: Tumor Immune MicroEnvironment Facility (Scientific Core)


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: WEIGERT, ROBERTO  (contact)

PROJECT_TERMS: Adolescent;Anaphase;Animal Model;Animals;Apoptosis;Area;B-Lymphocytes;CCR;Cell Cycle;Cell Line;Cell membrane;Cell Physiology;Cells;Child;Childhood Soft Tissue Sarcoma;Clinic;Collagen Fiber;cytokine;Data Analyses;Development;Disease;Disease Progression;drug efficacy;Ear;efficacy testing;Embryo;Experimental Designs;Extracellular Matrix;Genetically Engineered Mouse;Glycogen;Glycogen storage disease type II;high resolution imaging;Human;Image;imaging approach;Immune system;In Situ;in vivo;Induction of Apoptosis;Injections;intravital imaging;intravital microscopy;Invaded;Investigation;Label;Ligands;lung cancer cell;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;mechanical properties;melanoblast;Melanoma;Membrane Glycoproteins;Methods;Microscopy;migration;Mission;Modeling;Molecular;Monitor;mouse model;multimodality;Mus;Muscle;Muscular Atrophy;NADH;National Heart, Lung, and Blood Institute;Neoplasm Metastasis;neoplastic cell;Neutrophil Infiltration;novel;Nuclear;Organ;Pathologic;Patients;Pharmaceutical Preparations;Physiological;Procedures;Reporter;Research Personnel;response;Rhabdomyosarcoma;Rodent Model;Role;Signal Transduction;Skin;Squamous cell carcinoma;System;Therapeutic Intervention;Time;Tissues;TNF gene;Tongue;tool;Transgenic Animals;Translating;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Visualization

PROJECT_TITLE: Intravital Microscopy Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HESELMEYER, KERSTIN  (contact)

PROJECT_TERMS: Adopted;Algorithms;Alternative Splicing;analysis pipeline;Aneuploidy;Antibodies;archive data;Area;assay development;Bioinformatics;bioinformatics resource;Biological;Biological Assay;Biology;biomarker development;CCR;Cells;ChIP-seq;Classification;Clinical;clinical biomarkers;collaborative approach;Communities;Complex;Computational Biology;convolutional neural network;Data;data acquisition;Data Analyses;data archive;data management;Detection;differential expression;diverse data;DNA;DNA analysis;DNA sequencing;Enhancers;Epigenetic Process;epigenetic regulation;exome;exome sequencing;Gene Rearrangement;Genes;Genetic;Genome;genome sequencing;Goals;Hi-C;immune cell infiltrate;Immunogenomics;innovation;Intention;Laboratories;Machine Learning;Malignant Neoplasms;Maps;mass spectrometric imaging;Mediating;member;Methods;Micrococcal Nuclease;Molecular Profiling;Molecular Target;multimodality;Mutation Detection;nanopore;new technology;next generation sequence data;next generation sequencing;Oncogenes;Process;Proteomics;Protocols documentation;Research;Research Personnel;Resources;response;RNA;RNA Editing;screening;Sequence Analysis;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Spectral Karyotyping;Structure;T-Lymphocyte;targeted sequencing;Technology;technology development;tool;Training;transcriptome sequencing;transcriptomics;tumor;Tumor Antigens;tumor heterogeneity;Validation;Work

PROJECT_TITLE: Omics Technology facility


NIH_SPENDING_CATS: Cancer;Data Science;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Liver Cancer;Liver Disease;Lung;Lung Cancer;Microbiome;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: WANG, LIMIN  (contact)

PROJECT_TERMS: Affect;Bacteriophages;CCR;Chronic Disease;Communities;COVID-19;data acquisition;Data Analyses;data pipeline;Development;Disease;Epitopes;Extramural Activities;Health;HIV;Human;Human Resources;human virome;Immune response;Immunity;Immunoprecipitation;Individual;Infection;Leadership;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Methodology;Molecular;neuroinflammation;Pathogenesis;Pathogenicity;Patients;Procedures;Research Personnel;Research Project Grants;Research Support;response;Screening for Hepatocellular Cancer;Serology;Services;Technology;Viral;Virus

PROJECT_TITLE: Identification of viral exposure signatures for early detection of liver cancer


PI_NAMEs: BEYER, RACHEL  (contact)

PROJECT_TERMS: Allogenic;Annual Reports;antigen test;Antigen-Presenting Cells;Autologous;B-Lymphocytes;Biological Assay;Cells;cellular transduction;Clinical;Clinical Trials;Coculture Techniques;Complex;Contracts;Cooperative Research and Development Agreement;Data;Dendritic Cells;Detection;Development;Disease Progression;endonuclease;Endotoxins;Ensure;Epitopes;expectation;Failure;gene therapy;Generations;Good Manufacturing Process;Individual;individualized medicine;Infusion procedures;Interferon Type II;Interferons;Lead;manufacture;Manufactured Materials;manufacturing organization;meetings;Microbiology;mutant;Mycoplasma;neoantigens;novel;Operative Surgical Procedures;patient safety;Patient Schedules;Patients;Peptides;Performance;personalized medicine;Physiologic pulse;Plasmids;Production;Qualifying;Quality Control;Reagent;Reporting;Research;Residual state;Resources;Retroviridae;Safety;Signal Transduction;Specific qualifier value;Specificity;Sterility;System;T-Lymphocyte;Testing;Time;timeline;transduction efficiency;Treatment Protocols;vector;Viral;Virus;Work

PROJECT_TITLE: QC and Release Testing of Vector and Cell Clinical Gene Therapy Products


PROJECT_TERMS: Autologous;Blood Component Removal;Buffers;Cell Count;Cells;Centrifugation;Clinical;Clinical Trials;Custom;Data;Development;Ensure;equipment acquisition;exhaust;experimental study;Filtration;Formulation;Gammaretrovirus;gene therapy;Germ Cells;Goals;improved;Individual;Infection;Lentivirus;manufacture;manufacturing process;meetings;Methods;Mutation;Older Population;Operative Surgical Procedures;Patients;Phenotype;Population;precision medicine;preservation;Procedures;Process;Production;Proliferating;Protocols documentation;Recording of previous events;Retroviral Vector;Retroviridae;Safety;Specific qualifier value;stem;Sterility;System;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;tool;Transfection;tumor;Tumor-Infiltrating Lymphocytes;vector;Viral Vector;Virus;Work

PROJECT_TITLE: Use of lentivirus in individualized cell-gene therapy


PI_NAMEs: VALKOV, ANNA  (contact)

PROJECT_TERMS: Binding Proteins;biophysical properties;CCR;Cells;Development;experience;Human Resources;Immunization;Membrane Proteins;Methodology;nanobodies;Production;programs;Proteins;protocol development;Protocols documentation;Research;Resources;RNA-Binding Proteins;screening;structural biology;Technology;tissue culture;tool;Work

PROJECT_TITLE: Protein Technology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DURELL, STEWART  (contact)

PROJECT_TERMS: Alzheimer's Disease;Amyloid beta-Protein;amyloid structure;aqueous;Atomic Force Microscopy;beta barrel;Binding;Cholesterol;Data;drug development;Electrons;Ganglioside GM1;Goals;Grouping;Ion Channel;Lipids;Liposomes;Membrane;Modeling;Neurons;Penetration;Peptides;Periodicals;Structure;Toxic effect;Update;Variant

PROJECT_TITLE: Modeling Oligomeric Structures of Amyloid forming Peptides


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: WLOKA, KASKA  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Allogenic;anti-cancer research;artificial intelligence method;assay development;Autologous;Biological Assay;Cancer Patient;Cell Therapy;Cells;Childhood;chimeric antigen receptor T cells;Clinical;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Custom;Data;Data Analyses;design;Development;Disease Progression;DOCK8 deficiency;Ensure;Evaluation;Experimental Designs;fighting;Flow Cytometry;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;high dimensionality;HIV/AIDS;Human Herpesvirus 8;immune reconstitution;Immune system;immunodeficiency;Immunology;Immunooncology;Immunophenotyping;Immunotherapy;improved;Infusion procedures;Injections;interest;Interleukin-15;International;keratinocyte growth factor;Laboratories;Lymphocyte;Lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;Mature T-Lymphocyte;Measures;Medicine;meetings;Methods;Mission;Modernization;Monitor;Multicentric Angiofollicular Lymphoid Hyperplasia;Multiple Myeloma;National Cancer Institute;Natural Killer Cells;NCI Center for Cancer Research;novel;Patients;Pediatric Oncology;pediatric patients;Phenotype;Plasma Cells;Pleural effusion disorder;Preparation;Procedures;Productivity;prognostic;programs;recruit;Research Personnel;Resources;Sampling;Series;Services;Stem cell transplant;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;therapy outcome;Training;Wiskott-Aldrich Syndrome;young adult

PROJECT_TITLE: Clinical Research Correlatives Core


PI_NAMEs: KELLY, MICHAEL  (contact)

PROJECT_TERMS: Animal Model;Basic Science;Bioinformatics;Biological;Biological Assay;cancer type;Cell Lineage;Cell Surface Proteins;Cells;Chromatin;Clinical Research;Communities;Complex;Dedications;Detection;experience;Gene Expression Profiling;Gene Expression Regulation;Genetic;Genomics;Goals;Human;Immune;in situ sequencing;insight;Interest Group;Laboratories;Molecular;multimodality;NCI Center for Cancer Research;Peer Review;Population;Publications;Receptor Cell;Research Personnel;Research Project Grants;Resolution;RNA Sequences;Sampling;single cell analysis;Technology;Transcript;transcriptomics;tumor microenvironment;United States National Institutes of Health;Update

PROJECT_TITLE: Single Cell Analysis Facility


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: LONDON, NYALL  (contact)

PROJECT_TERMS: Area;cancer type;Chemotherapy and/or radiation;Clinical Trials;Development;Enrollment;Genes;Goals;Head and Neck Cancer;Immunotherapeutic agent;improved;In Vitro;in vivo;interest;Laboratories;Malignant Neoplasms;Metastatic/Recurrent;mouse model;mutant;Nasal cavity;Nose;Olfactory Epithelium;Olfactory Neuroblastoma;Operative Surgical Procedures;Patients;programs;Research Personnel;Series;Sinus;skull base;Skull Base Neoplasms;Smell Perception;therapeutic target;Translating;Treatment Effectiveness;tumor;tumorigenesis

PROJECT_TITLE: Mechanisms of olfactory neuroblastoma tumorigenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Precision Medicine

PI_NAMEs: THOMAS, ANISH  (contact)

PROJECT_TERMS: Aneuploid Cells;Aneuploidy;anti-cancer research;Antibody-drug conjugates;assay development;Automobile Driving;biobank;Biological Assay;Biological Markers;Biological Models;biomarker identification;Blood;Bone Marrow;Cancer Diagnostics;CCR;Cells;Cellular biology;Centromere;Chromosomal Instability;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Cultured Tumor Cells;diagnostic tool;digital;Diploidy;DNA Damage;drug development;Drug resistance;Epigenetic Process;Evolution;FDA approved;Flow Cytometry;Genome;Genomics;Heterogeneity;Immune;Immunohistochemistry;Immunologic Monitoring;Immunophenotyping;improved;In Vitro;indexing;industry partner;innovation;Invaded;Investigation;Kinetochores;Laboratories;Libraries;liquid biopsy;loss of function;Malignant Neoplasms;Measures;Microtubules;Modeling;Modification;Molecular;molecular marker;molecular phenotype;Molecular Profiling;Monitor;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;noninvasive diagnosis;Organoids;Outsourcing;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Physiological;Pleural effusion disorder;Poison;Postbaccalaureate;Postdoctoral Fellow;Principal Investigator;Process;Prognosis;prognosis biomarker;prognostic tool;Proliferating;Proteins;Proteomics;Recurrence;Research;Research Personnel;Sampling;screening;Services;single-cell RNA sequencing;small molecule inhibitor;Solid Neoplasm;Techniques;technology development;Testing;Therapeutic;therapeutic development;therapeutic target;therapy resistant;Tissues;tool;transcriptomics;translational goal;translational medicine;translational therapeutics;treatment effect;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue

PROJECT_TITLE: Development Therapeutics Branch-Translational Medicine and Therapeutics Group


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PI_NAMEs: GAVRILOVA, OKSANA  (contact)

PROJECT_TERMS: Adipose tissue;Affect;Animals;Ascorbic Acid;Biochemistry;Body Composition;Body Temperature;bombesin receptor subtype 3;Brain region;Brown Fat;CCR;cell growth;Cell Physiology;Complex;Deoxyglucose;Development;Diabetes Mellitus;Diabetic mouse;Disease;drug action;drug development;Eating;endoplasmic reticulum stress;energy balance;Energy Metabolism;epigenomics;Focal and Segmental Glomerulosclerosis;Food Energy;G-Protein-Coupled Receptors;Genetic;genetic approach;Glucose;glucose metabolism;glucose tolerance;Glycogen;glycosylation;GNAS gene;Growth;GTP-Binding Proteins;Hepatic;Homeostasis;Hormones;Immune response;Insulin;Insulin Resistance;insulin secretion;Islets of Langerhans;Laboratories;lipid biosynthesis;Measures;Metabolic;metabolic abnormality assessment;Metabolism;Molecular;Molecular Biology;Morphology;mouse model;Mus;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;National Institute of Diabetes and Digestive and Kidney Diseases;Nervous System;neural circuit;neurotrophic factor;nonalcoholic steatohepatitis;Obesity;obesity genetics;Operative Surgical Procedures;organ growth;Pathogenesis;Pharmacology;Phase;Phenotype;Physiological;Physiology;Prevalence;Principal Investigator;programs;Protein Biosynthesis;protein kinase D;Psychology;Purinergic P1 Receptors;Regulation;Research Personnel;Resistance;RGS Proteins;Role;Satiation;Serum;Services;Signal Transduction;Societies;Standardization;Testing;Tissues;Triglycerides;Tubular formation;uptake

PROJECT_TITLE: Metabolic Studies of Mouse Models of Obesity and Diabetes


NIH_SPENDING_CATS: Clinical Research

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: WALTER, MARY  (contact)

PROJECT_TERMS: Accounting;adipokines;adiponectin;Aliquot;Bar Codes;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen database;Blood;Clinical;Clinical Research;Collaborations;Collection;cytokine;Data;Databases;des-n-octanoyl ghrelin;Diabetes Mellitus;Endocrine;Ensure;Enteroglucagon;genetic testing;Genomic DNA;ghrelin;glucagon-like peptide 1;Hormones;Hour;Human;Instruction;International;Label;Leptin;Liquid substance;Measurement;Measures;Metabolic;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;Online Systems;Oxidative Stress;Plasma;Preparation;preservation;Principal Investigator;Process;programs;Protocols documentation;Reproducibility;Research;Research Personnel;Sampling;Services;Ships;Site;Specimen;Statutes and Laws;System;Technology;Testing;Tube;web platform;Whole Blood

PROJECT_TITLE: Clinical Research and Assay Support


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Nutrition

PI_NAMEs: WALTER, PETER  (contact)

PROJECT_TERMS: Area;Basic Science;Bile Acids;Biological Assay;Carbon;Clinical;Clinical Research;Cocaine;Collaborations;Communities;Deuterium;doubly-labeled water;Fructose;Galactose;Glucose;Glycerol;Human;Human Milk;instrument;Investigation;Isotopes;Label;Lactose;Lactulose;Levamisole;long chain fatty acid;Mannitol;Mass Fragmentography;mass spectrometer;Mass Spectrum Analysis;Measures;Metabolic;metabolic abnormality assessment;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;Nitrogen;Nonesterified Fatty Acids;novel;Palmitates;Pharmaceutical Preparations;Plasma;Positioning Attribute;programs;Protocols documentation;Research;Research Personnel;Research Project Grants;Resolution;small molecule;Source;stable isotope;Sucrose;Sweetening Agents;total energy expenditure;Tracer;United States National Institutes of Health;Urine;Very Long Chain Fatty Acid;Volatile Fatty Acids

PROJECT_TITLE: Clinical Mass Spectrometry Core


PI_NAMEs: REECE, JEFFREY  (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;absorption;ACE2;ADRBK1 gene;Alpha Cell;Area;Arizona;astrogliosis;Behavior;Biological Assay;Biomedical Research;blood glucose regulation;Bone Diseases;Budgets;Categories;Cells;Cellular Morphology;chemokine;Chromosome Segregation;Clinical;clinical center;Color;Complement;Computer software;Computers;Darkness;Development;Diabetes Mellitus;Digestive System Disorders;disability;Distal convoluted renal tubule structure;DNA;Endocrine System Diseases;Endotoxins;Equipment;equipment acquisition;Event;experience;finesse;Fluorescence;Fluorescence Microscopy;Fluorescent Dyes;Fluorescent Probes;Genetic;Giant Cells;Glucagon;Health;Hematological Disease;Heparitin Sulfate;Hepatic;Hepatitis C;Image;Image Analysis;Immune response;Immunohistochemistry;improved;Individual;Inflammatory;Inherited;instrument;Integrins;interest;Intramural Research;Intramural Research Program;islet;Journals;Kidney Diseases;Kinetics;Knowledge;Laboratories;Lasers;Licensing;Life;light microscopy;light transmission;Lighting;Lilium;Liver;Liver diseases;Maryland;meetings;Metabolic;Metabolic Diseases;Methods;Microscope;Microscopy;Midbrain structure;Mission;Modeling;Monitor;Moths;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Nutrition Disorders;Organism;Organoids;Pathology;PIK3CG gene;Preparation;Printing;Proteins;Proto-Oncogene Proteins c-akt;Publications;Qi;Renal tubule structure;Research;Research Personnel;Research Project Grants;Resources;Retinal Cone;rosin;Sampling;Scanning;service providers;Side;Signal Transduction;single nucleus RNA-sequencing;Slide;Spermatogenesis;Structure;Structure of retinal pigment epithelium;Subcategory;synucleinopathy;System;tau Proteins;Techniques;Technology;technology/technique;Thyroid Hormones;Time;Tissues;tool;Training;Transgenic Mice;ultra high resolution;United States National Institutes of Health;Urologic Diseases;vpr Gene Products

PROJECT_TITLE: Light Microscopy core for NIDDK


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS

ORG_NAME: DIVISION OF CLINICAL SCIENCES - NCI

PI_NAMEs: FIGG, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: Ascites;aspirate;Bar Codes;biobank;Biological;Biological Specimen Banks;Blood;Bone Marrow Aspiration;CCR;Cerebrospinal Fluid;Clinic;Clinical;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Data;Data Collection;Databases;Development;DNA;Ensure;Extramural Activities;Human;Laboratories;Life Cycle Stages;Methods;Mission;pharmacokinetics and pharmacodynamics;Pleural effusion disorder;Procedures;Process;Protocols documentation;repository;Research Design;Resources;Saliva;sample collection;Sampling;Services;software systems;Specimen;Specimen Handling;Time;Urine;Validation

PROJECT_TITLE: Biospecimen Processing and Biorepository


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunotherapy;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: ABCB1 gene;abiraterone;absorption;Agonist;analytical method;antagonist;Antineoplastic Agents;aurora kinase A;Azacitidine;BAY 54-9085;bevacizumab;Binding Proteins;Biological;Biological Assay;Biological Availability;Bortezomib;Camptothecin;cancer therapy;canine model;Carboplatin;CCR;Cells;Childhood Rhabdomyosarcoma;Cisplatin;Clinical;clinical center;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Design;clopidogrel;Collaborations;Combined Modality Therapy;Communities;Complex;Concentration measurement;Conduct Clinical Trials;cost;Coupled;Cyclophosphamide;cytotoxicity;Data;Depsipeptides;Detection;detector;Development;diffuse midline glioma;Disseminated Malignant Neoplasm;docetaxel;Dose;drug clearance;drug development;drug disposition;Drug Formulations;Drug Interactions;Drug Kinetics;drug metabolism;Drug Monitoring;Equation;Erlotinib;Etoposide;Excretory function;Extramural Activities;Finasteride;first-in-human;flavopiridol;Fluorescence;Frequencies;Future;Goals;Guidelines;High Pressure Liquid Chromatography;Imatinib;Immune checkpoint inhibitor;Immunotoxins;in silico;inhibitor;Institution;instrument;Interleukin-15;intraperitoneal;irinotecan;Ketoconazole;kinase inhibitor;lapatinib;large cell Diffuse non-Hodgkin's lymphoma;lenalidomide;Liquid substance;Locally Advanced Malignant Neoplasm;Malignant Neoplasms;mass spectrometer;Mathematics;Measures;MEKs;Melphalan;mesothelin;Metabolism;method development;Microdialysis;Midazolam;Modeling;Modification;Monoclonal Antibodies;MS-275;mucosal melanoma;Mus;Mutate;nanoparticle;nanoparticle drug;Nelfinavir;Nivolumab;nonhuman primate;novel anticancer drug;novel therapeutics;Paclitaxel;Patients;pembrolizumab;personalized approach;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacology;Phase;Phase I/II Trial;Phenylacetates;Phenylbutyrates;Physiological Processes;Plicamycin;pomalidomide;Population;pre-clinical;Pre-Clinical Model;Prodrugs;Program Development;programs;Randomized;Recombinants;Regimen;Relapse;Reproducibility;Research Personnel;response;Rhabdoid Tumor;Rhabdomyosarcoma;Route;Sampling;Scheme;simulation;Stress;SU 5416;Suramin;Tamoxifen;Tariquidar;temozolomide;Testing;Thalidomide;Therapeutic;Therapeutic Uses;Time;Tissues;TNP470;Topoisomerase-I Inhibitor;Topotecan;Toxic effect;tumor;United States National Institutes of Health;Valproic Acid;virtual patient;Xenograft Model

PROJECT_TITLE: Using Clinical Pharmacology Principles to Develop New Anticancer Therapies


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PI_NAMEs: WANG, HAO-WEI  (contact)

PROJECT_TERMS: AIDS related cancer;B-Cell Lymphomas;Benign;Biological Assay;Biopsy;Blood;Body Fluids;Bone Marrow;cancer cell;CCR;cell determination;Cell Surface Proteins;Characteristics;Clinical;Clinical Protocols;Communities;Detection;Detection of Minimal Residual Disease;Diagnosis;Diagnostic tests;Disease;Education;Eligibility Determination;Enrollment;Evaluation;Event;Fine needle aspiration biopsy;Flow Cytometry;Goals;Hematology;HIV/AIDS;Human Herpesvirus 8;Immunophenotyping;improved;Institution;Laboratories;leukemia/lymphoma;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Measurement;Medical;Monitor;Neoplasms;neoplastic cell;Patients;Play;primary effusion lymphoma;prognostication;Protocols documentation;Research;Residual state;response;Role;Selection for Treatments;System;targeted treatment;Techniques;Testing;therapeutic evaluation;Tissues;treatment response;Tumor Antigens;United States National Institutes of Health

PROJECT_TITLE: Flow cytometric analysis of benign and malignant tumors