NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Services;Patient Safety;Prevention;Telehealth

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Acutely ill patients with diabetes are often unable to maintain good glucose control in the hospital and are at risk of potentially devastating outcomes. The proposed project seeks to transform inpatient diabetes management through the implementation of automated insulin delivery (AID) utilizing a strategy that simultaneously addresses key safety elements surrounding in-hospital use of diabetes technology (i.e. use of disposable devices, nursing staff rapid response with alarms, electronic health records documentation, and remote monitoring of continuous glucose trends and insulin delivery rates). Findings from this project, including a randomized clinical trial and a detailed assessment of diabetes technology adoption, will inform the design of a larger study aimed at evaluating clinical outcomes and initiate a trajectory of research focused on the implementation of advanced diabetes technologies in the hospital.

PI_NAMEs: PASQUEL, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Address;Adoption;Adult;Age;Algorithms;arm;Attitude;blood glucose regulation;Body mass index;care providers;Caregivers;Caring;Characteristics;Clinical;Clinical Trials;clinically relevant;Continuous Glucose Monitor;Control Groups;cost;cost effectiveness;COVID-19 pandemic;Dangerousness;Data;design;Detection;Devices;diabetes management;Diabetes Mellitus;Documentation;efficacy evaluation;efficacy testing;Electronic Health Record;Elements;Ensure;European;Evaluation;Event;Exclusion;Frequencies;Glucose;glucose monitor;glucose sensor;glycemic control;Glycosylated hemoglobin A;group intervention;Health system;Healthcare Systems;Hospitalists;Hospitalization;Hospitals;Hyperglycemia;Hypoglycemia;Iatrogenesis;implementation barriers;implementation cost;implementation efforts;improved;Individual;Infection;Information Technology;Infrastructure;Infusion procedures;Injections;innovation;inpatient service;Inpatients;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intake;Interview;Knowledge;Methods;Mobility decline;monitoring device;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Nursing Staff;nutrition;open label;Outcome;Participant;Patient Care;patient safety;Patients;Periodicals;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Populations at Risk;pragmatic trial;primary endpoint;Protocols documentation;Pump;Randomized;randomized, clinical trials;Regimen;remote monitoring;remote patient monitoring;Renal function;Reproducibility;Research;response;Risk;Role;Safety;secondary endpoint;Severity of illness;sex;standard of care;standardized care;Steroids;Structure;Subgroup;Surveys;System;Technology;technology validation;Testing;Time;transmission process;treatment arm;treatment as usual;treatment effect;trend;trial design;Tube;type I and type II diabetes;United States;United States Food and Drug Administration;virtual model

PROJECT_TITLE: Automated Insulin Delivery for INpatients With DysGlycemia (AIDING)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (O1)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative People with cancer are vulnerable to SARS-CoV-2 infection and often experience severe outcomes of the resultant COVID-19. We have gathered more than 17,000 case reports of people with cancer and COVID-19 through the COVID-19 and Cancer Consortium registry. This project will lead to a greater understanding of outcomes in these patients, in particular cancer- related outcomes that may not be evident until years after the primary infection.

PI_NAMEs: REID, SONYA ;WARNER, JEREMY LYLE (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: 2019-nCoV;Acute;Adrenal Cortex Hormones;Adult;Advanced Malignant Neoplasm;Affect;anti-cancer treatment;Biometry;cancer care;cancer cell;cancer diagnosis;Cancer Prognosis;cancer recurrence;cancer therapy;Caring;Case Study;Cause of Death;Clinical;cohort;Communicable Diseases;Communities;Community Clinical Oncology Program;Community Practice;Comprehensive Cancer Center;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 survivors;COVID-19 susceptibility;COVID-19 treatment;Data;Data Coordinating Center;Decision Making;Dedications;Diagnosis;Disease;Disease remission;end of life;Enrollment;Ethnic Origin;experience;FAIR principles;feature selection;future pandemic;gastroesophageal cancer;General Population;Goals;Health Services Accessibility;Hematologic Neoplasms;Heterogeneity;high risk;Histology;Hodgkin Disease;Hospitalization;Immune system;Immunity;Immunocompromised Host;Immunotherapy;Impairment;Infection;infection risk;inhibitor;Insurance;JAK2 gene;Journals;Knowledge;Lead;machine learning algorithm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurable;Measures;meetings;Melanoma;Methods;Minority;Modification;Morbidity - disease rate;mortality;North America;novel coronavirus;Oncology;operation;Outcome;pandemic disease;Patients;Persons;Pharmaceutical Preparations;Population;Primary Infection;Process;Prognosis;programs;Publishing;Quality Control;Race;recruit;Registries;Renal Cell Carcinoma;Reporting;Research;Research Design;Research Personnel;response;Risk Factors;SARS-CoV-2 infection;Science;Screening for cancer;Secondary to;Site;sociodemographic factors;Source;Subgroup;Time;tumor progression;Underrepresented Populations;underserved community;United States;Vaccination;Viral Respiratory Tract Infection

PROJECT_TITLE: The COVID-19 and Cancer Consortium (CCC19) Registry

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (O1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Microbiome;Nutrition;Obesity;Physical Activity;Precision Medicine;Prevention;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The public health significance of this study lies in its potential to develop an improved understanding of the components of lifestyle interventions that are necessary to help adult cancer survivors with overweight and obesity improve dietary patterns to reduce weight and improve cardiometabolic health. Results will lead to optimized interventions that balance effectiveness with affordability, scalability, and efficiency to improve clinical implementation. These findings, coupled with integration and interpretation of multi-omic assessments to predict and evaluate response, will address a growing need for translational science that can result in more effective nutrition interventions for this population, and ultimately, advance survivorship care and move the field toward precision health.

PI_NAMEs: HILL, EMILY B. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Aftercare;Award;behavior change;behavior influence;Behavior Therapy;Behavioral;Biological;Biological Assay;Biological Markers;Body Weight;Body Weight decreased;Cancer Control;Cancer Survivor;cancer therapy;Cardiometabolic Disease;cardiometabolism;Caring;Carotenoids;Clinical;clinical implementation;clinical practice;Clinical Trials;Counseling;Coupled;Data;data visualization;Development;Diet;diet and exercise;dietary;Dietary intake;Dietary Intervention;Dietary Practices;Dietitian;Disease;Educational Curriculum;Effectiveness;efficacious intervention;Elements;Engineering;Equilibrium;Evaluation;Exercise;Exhibits;experience;Feces;Food;Goals;gut microbiome;Health;Health behavior change;implementation intervention;improved;Individual;individual response;innovation;Intervention;intervention effect;Knowledge;Lead;Life Style;lifestyle intervention;Linear Regressions;Malignant Neoplasms;Measures;Mentorship;metabolome;metabolomics;Methods;microbiome;modifiable behavior;Morbidity - disease rate;mortality;Multiomic Data;multiphase optimization strategy;multiple omics;novel;nutrition;nutrition education;Obesity;Obesity associated cancer;oncology program;Overweight;Participant;Pathway Analysis;Patient Self-Report;Pattern;Phase;Phenols;Phenotype;Physical activity;Physical Function;pilot trial;Plasma;Population Intervention;Precision Health;precision oncology;predicting response;predictive modeling;programs;prospective;Proteome;Proteomics;Public Health;Quality of life;Randomized;Recommendation;recruit;Recurrence;Research;Research Design;response;Risk;risk mitigation;skill acquisition;skills;social cognitive theory;Support Groups;Survivors;survivorship;Testing;theories;Training;Translational Research;Translations;Urine;Visualization;Visualization software;Weight

PROJECT_TITLE: Integration of multi-omics to predict and evaluate response during optimization of a nutrition intervention for cancer survivors with overweight and obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We will devise nonendoscopic early BE and EAC detection strategies and develop biomarkers to predict neoplastic progression in BE by 1. Analytically and clinically validating and commercializing the EsoPredict assay for personalized BE risk assessment; 2. Developing, validating, and commercializing the EsoDetect assay for noninvasive BE diagnosis; and 3. Conducting a prospective study of EsoPredict in tissues and sponge samples from BE patients.

PI_NAMEs: MELTZER, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Age;Alcohol consumption;Algorithms;Applications Grants;Award;Barrett Esophagus;Biological Assay;Biological Markers;Biopsy Specimen;Businesses;cancer risk;Chronic;Clinic Visits;Clinical;clinical practice;cohort;Columnar Epithelium;commercialization;Detection;Development;Devices;Diagnosis;diagnostic assay;diagnostic biomarker;Disease Progression;DNA;Dysplasia;Early Diagnosis;Endoscopy;Enrollment;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophagus;Feedback;Focus Groups;follow-up;Foundations;Funding;Future;Gastroesophageal reflux disease;gastrointestinal;Grant;Health system;High grade dysplasia;high risk;Histologic;improved;Incidence;indexing;Individual;industry partner;innovation;Interobserver Variability;Interview;Licensing;male;Malignant Neoplasms;Market Research;Marketing;Methylation;model building;Modeling;Multivariate Analysis;Neoplasms;Obesity;Outcome;Pathologist;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Physicians;population based;Porifera;Precancerous Conditions;Predictive Value;Primary Care Physician;Productivity;prognostic;prognostic assays;Prognostic Marker;prognostic value;progression marker;progression risk;prospective;Prospective Studies;Recommendation;recruit;response;Risk;Risk Assessment;Sampling;screening;Specimen;success;Surveillance Program;Symptoms;Testing;Time;Tissues;tobacco exposure;tool;Training;treatment planning;tumor progression;Update;Upper digestive tract structure;usability;Validation;validation studies;Weight

PROJECT_TITLE: Academic-Industrial Partnership for Barrett's Esophagus Detection and Risk Assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (57)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Lymphocyte activation gene-3 (Lag3) is an inhibitory coreceptor known to play an important role in interfering effector T cell immunity and in supporting Foxp3+ regulatory T cell functions. However, very little is known about the precise cellular and molecular mechanisms underlying Lag3 functions. The current application will test the novel mechanisms of Lag3 in supporting Treg functions.

PI_NAMEs: MIN, BOOKI  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Activated Lymphocyte;adaptive immunity;Allergic inflammation;Animals;anti-cancer;Antibodies;antiviral immunity;Attention;Attenuated;Autoimmune;Autoimmune Diabetes;autoimmune inflammation;Binding;biological adaptation to stress;Biological Models;Biology;Cell Physiology;Cellular Metabolic Process;Chronic;Cytoplasmic Protein;Cytoplasmic Tail;effector T cell;Equilibrium;Exons;Experimental Autoimmune Encephalomyelitis;extracellular;FOXP3 gene;Funding;Gene Activation;Gene set enrichment analysis;Genes;genetic signature;Germ Lines;Glycolysis;Goals;Immune;immune activation;immune checkpoint;Immune Targeting;Immunity;immunoregulation;Immunotherapy;Impairment;in vivo;Inflammation;Inflammatory Response;Interleukin-2;Ligand Binding;Ligands;Literature;loss of function;loss of function mutation;Lymphocyte;Lymphocyte Activation;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Molecular;mouse model;mutant;mutant mouse model;Mutation;neuroinflammation;novel;novel therapeutic intervention;novel therapeutics;Oxidative Stress;Oxidative Stress Pathway;Pathway interactions;Play;programs;Reactive Oxygen Species;receptor;Regulatory T-Lymphocyte;Role;Signal Pathway;Signal Transduction;Surface;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;therapeutic target;Tissues;transcriptome sequencing;transcriptomic profiling;Tumor Immunity;Virus Diseases

PROJECT_TITLE: The role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Contraception/Reproduction;Infertility;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Because mammalian reproduction takes place deep inside the body, the cilia function in the fallopian tube is not well understood and open to conjecture, thereby limiting the progress of infertility treatments. Here, we propose the first live dynamic investigation of cilia function in the mouse fallopian tube and the effect of ciliopathy on reproductive function. Our investigation of the role of oviduct cilia during reproduction will fill a significant knowledge gap and likely inform strategies to alleviate fertility defects and ectopic pregnancies in ciliopathy patients.

PI_NAMEs: LARINA, IRINA  (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: 3-Dimensional;Acute;Adhesions;Assisted Reproductive Technology;Behavior;Biological;blastocyst;Body System;Cell Line;Cilia;ciliopathy;Clinic;clinically relevant;Complex;Contrast Media;Data;Development;Diagnostic;Ectopic Pregnancy;Embryo;Environment;Epithelial Cells;Epithelium;Estrous Cycle;experimental study;Failure;female reproductive tract;Fertility;Fertility Disorders;Fertilization;fluid flow;Frequencies;Genetic;Human;human model;Image;imaging modality;imaging platform;imaging study;Imaging technology;in vivo;in vivo imaging;Incidence;Individual;Infertility;infertility treatment;innovation;insight;intravital imaging;Investigation;Knowledge;Laboratories;Link;Location;Mammalian Oviducts;Maps;Measurement;Measures;Methods;Modeling;mouse model;Movement;Mus;novel;Oocytes;Optical Coherence Tomography;optical imaging;Patients;Pattern;Periodicals;pharmacologic;Phase;Play;Positioning Attribute;preimplantation;prevent;Protocols documentation;Publishing;Regulation;Reproduction;reproductive;Reproductive Biology;reproductive function;Reproductive Process;reproductive system disorder;reproductive tract;Research Design;Resolution;Role;sex as a biological variable;Site;Smooth Muscle;Solid;sperm cell;technology development;Time;Uterus;Validation;Visual;Visualization;Woman

PROJECT_TITLE: In vivo investigation of cilia function in the fallopian tube

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Type 1 diabetes (T1D) is a complex disorder, arising from the action of multiple genetic and environmental risk factors. We have identified over seventy T1D risk loci and via fine mapping efforts showed that T1D risk variants mapped to regulatory regions of the genome, especially in immune related tissue. We aim to define the distinct role these risk variants play in initiation and progression of islet autoimmunity in circulating immune cells and identify biomarkers predictive of disease stage (islet autoimmunity and T1D) to guide development of risk prediction models.

PI_NAMEs: ONENGUT, SUNA  (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Autoimmunity;B-Lymphocytes;Bayesian Network;Beta Cell;Biological;Biological Markers;biomarker identification;case control;Catalogs;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;cohort;Collecting Cell;Collection;Communication;Complex;Data;design;Development;Diabetes Mellitus;diabetes mellitus genetics;Disease;Disease Progression;endocrine pancreas development;Enhancers;Environmental Risk Factor;Gene Expression;Gene Expression Profile;gene function;gene interaction;Genes;Genetic;Genetic Markers;Genetic Risk;genetic risk factor;Genetic Transcription;genetic variant;Genome;genome sequencing;genome wide association study;Goals;high risk population;Immune;Immunologic Markers;Immunologic Monitoring;Impairment;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intervention;islet;islet autoimmunity;islet cell antibody;Maps;Measures;Modeling;Newborn Infant;Nucleic Acid Regulatory Sequences;Output;Participant;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;predictive marker;Process;Prospective cohort;Proteins;Research;Research Project Grants;Resolution;Risk;risk prediction model;risk variant;Role;sample collection;Sampling;sex as a biological variable;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Technology;Time;Tissues;trait;transcription factor;transcriptome;transcriptomics;Untranslated RNA;Update;Variant;whole genome

PROJECT_TITLE: Identifying cell-type specific genetic control of T1D risk variants in TEDDY

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (O3)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Stroke is the 4th leading cause of mortality and the leading cause of disability for adults in the US. The Stroke Trials Network of Columbia and Cornell (STNCC) will continue to provide leadership and productivity within the NIH Stroke Net program. Developing, implementing, and completing nationwide multicenter randomized controlled trials for stroke treatment will benefit our US population by reducing the burden of this devastating disease.

PI_NAMEs: CONNOLLY, EDWARD SANDER;LEIFER, DANA ;MARSHALL, RANDOLPH S (contact);STIEG, PHILIP

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Academic Medical Centers;Acute;acute stroke;Address;Admission activity;Adult;African American;African American Women;Ancillary Study;Asian;Basic Science;Blood Vessels;Caring;Carotid Stenosis;Catchment Area;cerebral hemodynamics;Clinical;clinical biomarkers;clinical trial enrollment;Clinical Trials;Cognition;Community Outreach;Country;County;cryptogenic stroke;Data;demographics;Development;disability;Disease;economic disparity;Education;Educational Curriculum;Enrollment;Ensure;Ethnic Population;experience;Failure;falls;Fellowship;Funding;Future;Goals;Heart Atrium;Hispanic;Hospitals;improved;improved outcome;Infrastructure;innovation;Institution;International;K-Series Research Career Programs;Leadership;Manuscripts;medical schools;meetings;member;men;Minority Groups;mortality;multi-ethnic;National Institute of Neurological Disorders and Stroke;Neurologist;Neurology;Neurosciences;neurosurgery;New Jersey;New York;New York City;next generation;novel;outcome disparities;outreach program;patient subsets;Patients;Phase;Population;Populations at Risk;Positioning Attribute;Prevention;Productivity;professor;programs;Randomized, Controlled Trials;Recording of previous events;Recovery;Rehabilitation Centers;Research Personnel;revascularization;Role;Science;Scientist;screening;Side;Site;Standardization;Stroke;stroke clinical trials;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke risk;stroke therapy;stroke trials;Stroke Volume;StrokeNet clinical trials;StrokeNet trials;success;symposium;Testing;Time;Training;Training and Education;Training Programs;trial enrollment;underserved minority;United States National Institutes of Health;videoconference;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE More than 891,000 U.S. women have an endometrial cancer history, making it the second largest cancer survivor group among women. Racial disparities have been reported across the endometrial cancer continuum—from recognition of symptoms leading to diagnosis through receipt of guideline recommended cancer therapy and survivorship care. The Carolina Endometrial Cancer Study is a diverse, population-based cancer epidemiology survivor cohort that collects detailed information on novel molecular characteristics; medical history; cancer treatment and follow-up care; individual- and contextual-level social determinants of health; and behavioral and lifestyle factors to advance our understanding of endometrial cancer survivorship.

PI_NAMEs: NICHOLS, HAZEL B (contact);OLSHAN, ANDREW

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Accounting;Address;anti-cancer research;Area;Behavioral;Biological;Black race;black women;black/white disparity;Breast;Cancer Biology;cancer care;Cancer Control;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Caring;Cells;cellular resilience;Cessation of life;Characteristics;cohort;Cohort Analysis;Collaborations;Collection;community-level factor;Data;Data Collection;design;Diagnosis;Diagnostic;Disease;Disparity;DNA;Economics;Endometrial Carcinoma;Enrollment;Ensure;Equitable healthcare;Ethnic Origin;experience;Family;follow-up;Foundations;Germ Lines;Guidelines;Gynecologic Oncology;Health system;Hemorrhage;High Prevalence;Histologic;Incidence;Individual;inequitable distribution;Inequity;Infrastructure;insurance claims;Interview;Investigation;lifestyle factors;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;Medical History;Medical Records;Modeling;Modernization;Molecular;molecular subtypes;mortality;mortality disparity;multidisciplinary;National Comprehensive Cancer Network;neoplasm registry;Newly Diagnosed;North Carolina;novel;Outcome;Outcomes Research;Paraffin;Participant;Pathology;Pathology Report;Patient advocacy;Patients;Physiological;Physiology;population based;Postmenopause;Prognosis;programs;prospective;Provider;psychosocial;Quality of life;Questionnaires;Race;racial disparity;Recommendation;Recording of previous events;Records;recruit;Recurrence;Recurrent disease;Reporting;Research;Resources;Retrieval;Rural;Sampling;Science;segregation;social;social deprivation;Social Environment;social health determinants;Societal Factors;Societies;Structural Racism;Surveys;Survivors;survivorship;Symptoms;System;Telephone;The Cancer Genome Atlas;tumor;Tumor Biology;unconscious bias;United States;Variant;Visit;Weight;White Women;Woman;Writing

PROJECT_TITLE: The Carolina Endometrial Cancer Study: A population-based survivor cohort


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Stanford Stroke Center has developed a comprehensive stroke network consisting of Stanford Healthcare, Stanford Lucile Packard Children’s Hospital and 6 additional regional stroke centers that provide a high volume of patient enrollment into NINDS funded stroke trials. Our StrokeNet fellowship program provides comprehensive training in clinical trial design, implementation and analysis. In addition, Stanford faculty members propose new clinical trials for implementation through the NINDS Stroke Network. Project Narrative Page 7

PI_NAMEs: LANSBERG, MAARTEN G (contact)

PROJECT_TERMS: acute stroke;American Heart Association;American Stroke Association;Ancillary Study;Area;Basic Science;Blood Vessels;Brain Injuries;Brain Ischemia;brain tissue;Caring;Cerebral hemisphere hemorrhage;Cerebrovascular Disorders;Certification;Childhood stroke;Cilostazol;Clinical;Clinical and Translational Science Awards;clinical center;clinical practice;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Coma;Comprehensive Health Care;Country;Data Coordinating Center;Data Set;design;Development;Diagnosis;Disease;Education;efficacy testing;Emergency Medicine;Enrollment;epidemiology study;Evaluation;experience;Faculty;Fellowship;Fellowship Program;Funding;Generations;Goals;Grant;Healthcare;Hospitals;Image;imaging approach;Imaging Techniques;Infrastructure;innovation;Intervention;Joints;Laboratories;Laboratory Research;large-scale imaging data;Magnetic Resonance Imaging;Master of Science;Medical;medical schools;member;Mentors;Mission;multidisciplinary;National Institute of Neurological Disorders and Stroke;neuroimaging;neurological rehabilitation;Neurologist;Neurology;Neurosurgeon;neurosurgery;neurovascular;novel strategies;Nurses;Nursing Faculty;participant enrollment;patient population;Patient Selection;Patients;Pediatric Hospitals;Phase;Physicians;Practice Guidelines;Procedures;Prognosis;programs;Protocols documentation;Publications;Publishing;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;Running;Scientist;Selection Criteria;Site;Specialist;standard of care;stem cell therapy;Stroke;stroke patient;Stroke prevention;stroke recovery;stroke therapy;stroke trials;success;Techniques;Testing;Time;Training;trial enrollment;United States;United States National Institutes of Health;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Stanford University Regional Coordinating Stroke Center for the NIH Stroke Trials Network


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Comparative Effectiveness Research;Health Services;Lung;Lung Cancer;Prevention

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research on evidence synthesis via cancer-focused data integration is relevant to public health because it is a critical tool for evaluating lung cancer screening strategies and ultimately reducing cancer mortality. As lung cancer screening is implemented in more diverse settings, the applicability of trial findings to nationally representative populations is challenged. This work aligns with NCI’s priority to increase health equity across the cancer continuum because as a result of applying the proposed methods, we will produce high-quality evidence of lung cancer screening strategies for populations traditionally underrepresented in trials.

PI_NAMEs: ROBERTSON, SARAH E (contact)

PROJECT_TERMS: Adherence;Age;Behavioral Risk Factor Surveillance System;burden of illness;Cancer Control;Cancer Intervention and Surveillance Modeling Network;cancer prevention;career;Characteristics;Clinical;community setting;comparative effectiveness;Complex;Data;data integration;Data Science;Data Set;Decision Making;Effectiveness;Epidemiology;Equilibrium;Ethnic Origin;experience;Genus - Lotus;health equity;Heterogeneity;improved;Individual;individual patient;insight;insurance claims;Learning;lung cancer screening;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;Meta-Analysis;Methods;Modeling;models and simulation;mortality;National Cancer Institute;National Health and Nutrition Examination Survey;novel;Participant;Pattern;personalized decision;Policies;Population;Prospective cohort;Prospective Studies;Public Health;Race;randomized trial;Randomized, Controlled Trials;Recommendation;Registries;Research;Research Personnel;Sampling Studies;Science;screening;sex;simulation;skills;Source;Subgroup;Surveys;Target Populations;tool;Training;trial comparing;Underrepresented Populations;United States Preventative Services Task Force;Work

PROJECT_TITLE: Learning about the effectiveness of lung cancer screening in real-world target populations


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Clinical trials for stroke treatments should include patients who represent all communities, including those from communities who often lack opportunities to participate. The highly successful Wake Forest Stroke Net has grown as a regional network that 1) includes multiple hospitals across the entire state of NC, across the borders of neighboring states, and recently WI and IL; 2) serves diverse race-ethnic, urban, and rural populations, and 3) is committed to improving clinical trial success by connecting with communities to advance stroke care. We have the leadership, experience, and passion to continue to positively impact Stroke Net clinical trials focused on acute stroke treatment, stroke prevention, and stroke rehabilitation and recovery.

PI_NAMEs: BUSHNELL, CHERYL D (contact);WOLFE, STACEY QUINTERO

PROJECT_TERMS: acute stroke;Address;Adult;Advocate;African American;Alabama;Alaska Native;American Indians;Awareness;Baptist Church;Blood Vessels;Cardiovascular system;career;Caring;Catchment Area;Chicago;Childhood;Cities;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Community Health;Community Outreach;comparative effectiveness trial;Consent;Country;design;Education;Emergency Medicine;Enrollment;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;experience;Exposure to;first-in-human;Funding;Geography;Goals;Health;health equity;health inequalities;Health Personnel;Health system;Heart Atrium;Home;Hospitals;Illinois;improved;Influentials;innovation;Institution;Intervention;Knowledge;Leadership;Learning;Location;Medical center;medical schools;meetings;Methodology;Mission;Modeling;multidisciplinary;Neurology;Neurosciences;neurosurgery;next generation;North Carolina;operation;outreach;outreach program;Participant;participant enrollment;participant retention;Patient Discharge;Patients;Performance;performance site;Persons;Phase;pilot test;Population;Population Heterogeneity;Positioning Attribute;pragmatic trial;Prevention;Productivity;programs;Protocols documentation;Publications;racial diversity;racial population;Radiology Specialty;Randomized;Recovery;recruit;Registries;Rehabilitation therapy;Research;Research Personnel;Resources;Rural;Rural Community;Rural Population;Seasons;Secondary Prevention;Site;socioeconomics;South Carolina;Southeastern United States;Stroke;Stroke Belt;stroke clinical trials;stroke patient;Stroke prevention;stroke recovery;stroke rehabilitation;stroke therapy;stroke trials;StrokeNet trials;success;Time;Training;Training Programs;Trust;Universities;Urban Community;Urban Population;Wisconsin;working group

PROJECT_TITLE: Wake Forest StrokeNet


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: PROJECT NARRATIVE Cadherin-11, an adhesion molecule, expressed on various cells during the development of tissue fibrosis, is an important mediator of the development of fibrosis and systemic sclerosis (scleroderma) is a potentially devastating disease clinically manifesting as progressive fibrosis of skin and lungs. The current proposal will extend these findings and determine the extent to which cadherin-11 regulates macrophages, type II alveolar epithelial cells and fibroblasts during the development of fibrosis. We will also use cadherin-11 to identify novel mediators of fibrosis and target cells with cadherin-11 targeted nanoparticles to treat lung fibrosis.

PI_NAMEs: AGARWAL, SANDEEP K (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;alveolar epithelium;Architecture;Autoimmune;Behavior;Biology;Bleomycin;cadherin-11;Cadherins;Cause of Death;Cell Adhesion Molecules;Cell surface;Cells;Clinical;Complex;Cre lox recombination system;Data;Deposition;Dermal;Development;Disease;effectiveness evaluation;Engineering;Epithelial Cells;Exposure to;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;Gene Expression Profile;Genetic Transcription;Heart;In Vitro;in vivo;inhibitor;injured;Interstitial Lung Diseases;Intestines;intraperitoneal;Label;Laboratories;lipid nanoparticle;liposomal delivery;Liposomes;Liver Fibrosis;LoxP-flanked allele;Lung;lung development;Macrophage;Mediator;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;nanocarrier;nanoparticle;Nanotechnology;new therapeutic target;novel;novel strategies;Pathogenesis;Pathway interactions;Population;prevent;Pulmonary Fibrosis;recruit;Regulation;Role;Scleroderma;single-cell RNA sequencing;skin fibrosis;STAT3 gene;System;Systemic Scleroderma;targeted treatment;Therapeutic;Tissues;tool;transcriptomics;Transgenic Mice;uptake

PROJECT_TITLE: UNDERSTANDING CADHERIN-11 IN THE DEVELOPMENT AND TREATMENT OF LUNG FIBROSIS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

ORG_STATE: MI

PHR: Project Narrative The Nominee's projects involve the study of repetitive mild traumatic brain injury (rmTBI), Gulf War Veterans' Illnesses (GWVI) and substance abuse disorders (SUD). These conditions are chronic, the symptoms worsen over time, they are associated with numerous co-morbid disorders, and there are no effective treatments for them. rmTBI and GWVI are often associated with SUDs, particularly opiate drugs. Opiate abuse represents a significant problem by itself, and can increase the risk of overdose, but it compounds the problems associated with rmTBI and GWVI. It is known that rmTBI, GWVI and SUDs can significantly alter the gut microbiome so it is important to understand if these conditions can be improved by rebalancing the disease-altered gut microbiome. Work on this project will capitalize on prior VA instrument grant support that allowed our lab to acquire automated, high-throughput instrumentation to analyze the gut microbiome. This project is highly relevant to Veterans health and to the VA healthcare mission.

PI_NAMEs: KUHN, DONALD M (contact)

PROJECT_TERMS: Affect;Alcohol abuse;Animal Model;Animals;Anxiety;Award;Behavioral;Behavioral Symptoms;Biological Models;Brain;Bypass;Carbohydrates;career;Categories;Chronic;Clinical;Clinical Trials;Cognitive;comorbidity;Complex;Craniocerebral Trauma;Development;Diet;Disease;Dose;dysbiosis;effective therapy;Effectiveness;Elements;Epidemic;Equilibrium;evidence base;exposed human population;Exposure to;Failure;falls;Family;Fat-Restricted Diet;Fatigue;Fatty acid glycerol esters;fecal transplantation;Fermentation;Funding;Gastrointestinal Diseases;Goals;Grant;Gulf War;Gulf War veteran;gut dysbiosis;gut microbiome;HDAC6 gene;Head;head impact;Health;Healthcare;Hemorrhage;High Fat Diet;high reward;high risk;Home;Human;humanized mouse;Impaired cognition;improved;Individual;individualized medicine;inhibitor;innovation;instrument;instrumentation;Investigation;Laboratories;Length;Life Style;Mental Depression;microbiome;microbiota;mild traumatic brain injury;Military Personnel;Mission;Modeling;Mood Disorders;mouse model;Mus;nerve agent;neuropathology;novel;novel therapeutics;Obesity;Opioid;opioid abuse;opioid overdose;opioid use;Outcome;overdose risk;Oxycodone;oxycodone self-administration;Paralysed;Pathologic;Pathology;Permethrin;Persian Gulf Syndrome;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Post-Traumatic Stress Disorders;prescription drug abuse;Probiotics;programs;psychiatric comorbidity;pyridostigmine;Recording of previous events;reduce symptoms;Rehabilitation therapy;Research;Research Activity;Risk;Risk Factors;Scientist;Self Administration;service member;Services;Severities;Skull Fractures;Sleep;Sleep disturbances;Smoking;stool sample;Structure;Substance abuse problem;success;symptom cluster;Symptoms;TBI treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time;Toxin;translational approach;translational study;Uncertainty;Veterans;Volatile Fatty Acids;western diet;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative To survive in the nutrient- and oxygen-deprived tumor microenvironment (TME), cancer cells undergo a drastic metabolic reprogramming where they upregulate both their endogenous lipid synthesis and exogenous uptake of lipids. Although this altered lipid metabolism has the potential to serve as a powerful diagnostic approach and research tool in cancer biology, current methods to evaluate lipid profiles are unable to provide single-cell analysis and lack spatial precision. Here, we describe a unique platform for lipid profiling of cancer and cancer- associated cells in intact tissue samples at single-cell level by probing inherent molecular vibrations using spectral coherent anti-Stokes Raman scattering (CARS) microscopy, simultaneously with RNA imaging by stimulated Raman excited fluorescence (SREF).

PI_NAMEs: HEILSHORN, SARAH C (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affect;Biological;Cancer Biology;cancer cell;Cancer Patient;cancer type;carbene;Carbon;Cell Culture Techniques;cell type;Cells;cellular imaging;Cellular Metabolic Process;clinically relevant;Coculture Techniques;Collaborations;Custom;Data Analyses;design;Detection;Development;diagnostic strategy;diagnostic tool;Diagnostics Research;Disease Progression;Dyes;Energy-Generating Resources;Ensure;Fatty Acids;Fluorescence;Fluorescence Microscopy;fluorophore;fundamental research;Gene Expression;Genes;Genetic Transcription;Goals;Growth;Hypoxia;Image;imaging platform;Immune response;immunocytochemistry;Immunohistochemistry;Immunologic Stimulation;In Vitro;Individual;innovation;interest;Isotope Labeling;Isotopes;Label;Lasers;Left;Length;Link;lipid metabolism;Lipids;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurement;Measures;Mesothelial Cell;Messenger RNA;Metabolic;metabolic profile;Methods;Microscope;Microscopy;Molecular;multiplexed imaging;Neoplasm Metastasis;Nitriles;novel;novel imaging technology;Nutrient;Omentum;Oncogenes;Oxidative Stress;Oxygen;Patients;Pattern;Phenotype;pi bond;Population;Primary Neoplasm;Protein Analysis;protein biomarkers;protein expression;Proteins;Resistance;Resolution;RNA;RNA Probes;Sampling;saturated fat;scale up;Series;Shapes;single cell analysis;Specificity;stemness;System;Techniques;Technology;Time;Tissue Sample;Tissues;tool;Transcript;tumor;tumor metabolism;tumor microenvironment;Tumor Tissue;Unsaturated Fats;uptake;vibration

PROJECT_TITLE: Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Insulin resistance causes metabolic diseases such as type 2 diabetes, heart attacks, strokes and liver failure– diseases that disproportionately affect veterans as compared to the general US population. Using genetic and genomic data from veterans treated for insulin resistance, this project aims to identify new human insulin resistance genes and prove through nature’s own clinical trials that they would make good targets for therapeutic development.

PI_NAMEs: MAJITHIA, AMIT  (contact)

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Affect;African ancestry;Aftercare;Alleles;Atherosclerosis;bariatric surgery;biobank;Biological;Biological Assay;Biological Markers;Body fat;Body Weight decreased;Caloric Restriction;Calories;Candidate Disease Gene;Cardiovascular Diseases;Catalogs;CD36 gene;Cell Physiology;Cellular Assay;Chronic;Clinical;clinical effect;Clinical Research;Clinical Treatment;Clinical Trials;Code;Conduct Clinical Trials;Credentialing;Data;Development;Diabetes Mellitus;Diagnosis;Diet;Disease;Dose;drug development;Epidemic;Etiology;European;exome sequencing;experimental study;Failure;Fatty Liver;fatty liver disease;functional genomics;Future;gene discovery;Gene Expression;gene function;General Population;Genes;Genetic;genetic association;Genetic Transcription;genetic variant;Genome;Genome engineering;genome wide association study;Genomic approach;genomic data;Genomics;Genotype;Health;health record;Human;Human Genetics;in vivo;Individual;Insulin;Insulin Resistance;insulin sensitivity;interest;Investigation;Laboratories;Life;Link;Lipids;Liver diseases;Liver Failure;Malignant Neoplasms;Measures;metabolic abnormality assessment;Metabolic Diseases;Mining;Modernization;Mutation;Myocardial Infarction;Nature;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Participant;pharmacologic;Phenotype;Population;PPARG gene;prevent;Process;programs;prospective;Proteins;Publishing;rare variant;Records;resistance gene;response;Sampling;Series;Serum;Severities;side effect;Signal Transduction;Source;statistics;Stroke;Study of serum;targeted treatment;Testing;theories;Therapeutic;therapeutic development;therapeutic gene;therapeutic target;Thiazolidinediones;Tissue Sample;transcriptome;transcriptome sequencing;transcriptomics;translational therapeutics;Variant;Veterans;Work

PROJECT_TITLE: Credentialing metabolic disease genes through human genetics and functional genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDA-L (01)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Several challenges exist that limit the realized potential of cell-based therapies in the setting of solid tumors, including high manufacturing costs, poor intra-tumoral recruitment, and limited expansion of adoptively transferred cellular products. Utilizing HPV-associated cancers as a model system, we propose innovative concepts and engineering strategies to facilitate in situ proliferation of adoptively transferred T cells that can potentially transform our approach to adoptive cell therapies.

PI_NAMEs: PAI, SARA ISABEL (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;anti-tumor immune response;Antigens;antitumor effect;Attenuated;Autologous;Binding;Biological;Biological Models;Blood Vessels;Bolus Infusion;cancer cell;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Therapy;Cells;chemokine receptor;Chimeric Proteins;Clinical Trials;Color;combinatorial;Complex;congenic;cost;Cues;CXC Chemokines;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;Diagnosis;Dose;efficacy evaluation;engineered T cells;Engineering;Epitopes;experimental study;Fc domain;first-in-human;Flow Cytometry;Frequencies;Future;Head and Neck Squamous Cell Carcinoma;HLA A*0201 antigen;HLA-A gene;HPV positive;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;IgG1;Immune;Immunocompetent;Immunologic Memory;Immunotherapeutic agent;improved;In Situ;in vivo;Individual;Industry;industry partner;Infusion procedures;innovation;Institution;Interleukin-12;Interleukin-15;Interleukin-2;intravital imaging;Letters;Ligands;Malignant Neoplasms;manufacturability;manufacturing cost;Measures;Mediating;migration;Modeling;Monitor;Multicenter Studies;multidisciplinary;Mus;novel;Oncoproteins;oral HPV-positive head and neck cancers;Patients;pembrolizumab;Peptides;Peripheral;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;preclinical study;Proliferating;recruit;Reporter;Role;Safety;safety assessment;Signal Transduction;Solid Neoplasm;subcutaneous;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted delivery;targeted treatment;Technology;Toxic effect;Transgenic Mice;Translating;tumor;United States;Virus

PROJECT_TITLE: Cue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck Cancers


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PHR: The proposed research is relevant to public health because we are conducting research that will advance our understanding of hyper and hypo connectivity functional and anatomical networks in Ab and tau mouse models. The proposed work is relevant to the component of NIH’s mission of supporting the pursuance of novel and innovative methods such as combining imaging, spatial proteomics, learning and memory and machine learning to understand and potentially treat AD, a disease that is on the rise and has significant health consequences.

PI_NAMEs: PAUTLER, ROBIA G (contact);SAMEE, MD. ABUL HASSAN

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Anatomy;Animal Model;Animals;Automobile Driving;Behavior;Behavioral;blind;Brain;Brain region;brain volume;Communication;Data;Data Set;Databases;Dependence;Diffusion Magnetic Resonance Imaging;Disease;economic impact;Exhibits;Functional Magnetic Resonance Imaging;Genes;Genetic;genetic association;genome wide association study;Goals;Health;Human;human data;hyperphosphorylated tau;Image;imaging study;in vivo;innovation;Intervention;Learning;Link;Machine Learning;machine learning model;Magnetic Resonance Imaging;Maps;Memory;Methods;Mission;Modeling;Molecular;mouse model;Mus;nano-string;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;novel;Outcome;Pathway interactions;Patients;Pattern;personalized therapeutic;Persons;Phase;Positron-Emission Tomography;preclinical study;Preclinical Testing;profiles in patients;protein expression;Proteomics;Public Health;Research;Resolution;Rodent;Senile Plaques;Sociology;tau Proteins;tau-1;Technology;Testing;Time;tool;United States National Institutes of Health;white matter;Work;World Health Organization

PROJECT_TITLE: Incorporating Spatial Proteomics to Understand the Basis of Hyper and Hypoconnectivity in mouse models of AD

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Colorectal cancer is one of the major causes of all cancer related deaths and a critical challenge in colorectal cancer outcome is lack of therapies designed to combat metastatic disease. Diet and obesity are among the major lifestyle choices that can affect colorectal cancer risk, however not much is known about how pro-obesity diets can affect cancer metastasis. This proposal investigates the molecular mechanisms underlying how pro- obesity high fat diets impact colorectal cancer metastasis, revealing therapeutic vulnerabilities and enabling evidence-based effective dietary recommendations.

PI_NAMEs: GOSWAMI, SWAGATA  (contact)

PROJECT_TERMS: Acceleration;Affect;Automobile Driving;Bioinformatics;Biology;cancer initiation;Cancer Model;Cancer Patient;cancer risk;cancer stem cell;career;Cell Communication;Cells;Cellular Metabolic Process;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colonoscopy;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer risk;combat;Computer Analysis;Cues;Cytotoxic T-Lymphocytes;Data;Diet;diet-induced obesity;dietary;dietary control;Dietary Intervention;Disease;DNA Sequence Alteration;driver mutation;Educational process of instructing;Educational workshop;epidemiology study;evidence base;evidence based guidelines;Evolution;Exercise;Fibroblasts;Future;gastrointestinal;Genetic Engineering;Goals;High Fat Diet;Homeostasis;Human;Immune;Impairment;in vivo;in vivo Model;Injury;innovation;insight;intestinal epithelium;Intestines;Investigation;Knock-out;Knockout Mice;KRAS2 gene;Life Style;Literature;Liver;Lymphocyte;Macrophage;Malignant Neoplasms;Mediating;Mentors;Mentorship;Metabolic;metabolomics;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;Molecular;mortality;mouse model;Mus;Mutation;Natural regeneration;Neoplasm Metastasis;neoplastic cell;Nutrient availability;Obesity;obesogenic;Oncogenic;Operative Surgical Procedures;Organoids;Outcome;Pathology;Phase;Phenotype;Physiological;Population;prevent;programs;Proteins;PTEN gene;Recommendation;regenerative;Regulation;Reporter;Research;response;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;stem cell niche;stem cell population;stem cells;stemness;Stromal Cells;Stromal Neoplasm;sulfated glycoprotein 2;symposium;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy design;TP53 gene;Training;transplant model;Transplantation;tumor;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression

PROJECT_TITLE: Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Lung;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative The goal of this research is to understand the role of lung afferents in controlling eupneic breathing, and how the breathing network reconfigures to generate gasping and arousal. This basic science research is translational and will provide important insights into breathing disorders associated with autonomic dysregulation and the failure to arouse in response to hypoxia. The research will also test a concept how breathing controls emotions.

PI_NAMEs: RAMIREZ, JAN M. (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Anesthesia procedures;Animals;Anxiety;Area;Arousal;Ballistics;basal forebrain;Basic Science;Behavioral;Brain;Breathing;Cell Nucleus;Complex;connectome;Coupling;Data;Deglutition;Emotional;Emotions;expiration;Failure;Generations;genetic approach;Genomics;Goals;Grant;Head;Heart;Heart Arrest;Hypoxia;In Vitro;in vivo;inhibitory neuron;insight;Link;locus ceruleus structure;Lung;lung volume;Medial;Metabolic;Modeling;Molecular;Motor output;Mus;Nervous System;neuromechanism;Neurons;Obstructive Sleep Apnea;optogenetics;Organism;Outcome;Phase;Population;Population Dynamics;preBotzinger complex;Prefrontal Cortex;Preparation;recruit;Research;Respiration Disorders;respiratory;response;Role;Running;Seminal;Sleep disturbances;Sudden infant death syndrome;System;Testing;Urethane;Vagotomy;Viral;vocalization

PROJECT_TITLE: Unraveling respiratory rhythm generation in medullary and supramedullary networks

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioids;Pain Research;Patient Safety;Prevention;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Over 10 million individuals in the United States are opioid tolerant due to current or prior opioid exposure, which is correlated with poor outcomes and greater health risks during surgical care, but current strategies to optimize postoperative pain management and ensure safe opioid prescribing focus primarily on patients who lack exposure to opioids. In this prospective study, we will examine the perioperative experiences of patients with preoperative opioid tolerance following surgery in order to create and test a clinical care pathway to reduce high-risk prescribing practices, readmissions, and length of stay, and enhance patient-reported outcomes including pain. These findings will provide the necessary evidence to guide appropriate opioid prescribing during surgical care and optimize surgical recovery for patients with opioid tolerance.

PI_NAMEs: BICKET, MARK  (contact);WALJEE, JENNIFER FILIP

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Acute Pain;Acute pain management;Address;Adult;Affect;American;Attention;Blue Cross;Blue Shield;Calibration;care coordination;Caring;Case Mixes;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;clinical care;Communication;comorbidity;Consumption;Data;Development;Dose;Effectiveness;effectiveness evaluation;effectiveness/implementation design;Elements;Ensure;Event;evidence base;Expenditure;experience;Exposure to;Failure;Funding;Geographic Factor;Geography;Goals;Guidelines;Health;health care service utilization;Healthcare;High Prevalence;high risk;hospital care;hospital readmission;Hospitals;Hybrids;improved;Individual;Infrastructure;Intervention;Interview;Knowledge;Length of Stay;Measures;Mediating;Michigan;Morbidity - disease rate;mortality;Naloxone;naloxone dispensing;novel;Operative Surgical Procedures;opiate tolerance;Opioid;opioid exposure;opioid therapy;opioid use;Outcome;overdose risk;Pain;Pain management;pain outcome;pain relief;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patient Self-Report;patient tolerability;Patient-Focused Outcomes;Patients;patients who use opioids;Perioperative;Perioperative Care;Perioperative complication;Postoperative Pain;Postoperative Period;prescription opioid;Prevalence;prevent;primary outcome;programs;prospective;Prospective Studies;Provider;provider factors;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;recruit;Reporting;Risk;risk mitigation;Sampling;satisfaction;secondary outcome;sociodemographic factors;Structure;surgery outcome;Testing;treatment as usual;United States;Ventilatory Depression;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Improving Perioperative Care for Patients with Opioid Tolerance

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Patient Safety;Precision Medicine;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE This project aims to help us better understand how individual differences in our genes can affect some of the most commonly prescribed hormone-containing medications, combined oral contraceptive pills. Individual genetic differences may place some women at higher risk of contraceptive failure while using combined oral contraceptive pills, while other genetic differences could increase the risk of bothersome side effects that lead to early contraceptive discontinuation and higher risk of unintended pregnancies. The results of this project will help us incorporate precision and personalized medicine into individualized counseling for hormonal contraception based on individual genetic differences, leading to patients making more informed decisions about their use of hormone-containing medications.

PI_NAMEs: LAZORWITZ, AARON  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Albumins;Area;base;biobank;Biological Markers;Caring;carrier status;Client satisfaction;Clinical;clinical application;clinically actionable;clinically relevant;cohort;Collection;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Data;design;Desogestrel;Development;drug efficacy;Drug Kinetics;drug metabolism;Drug Prescriptions;Enrollment;Enzymes;Estradiol;Estrogen Metabolism;Estrogens;Ethinyl Estradiol;Etonogestrel;experience;Failure;Family;Female;fetal;Genes;Genetic;genetic regulatory protein;genetic variant;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;genomic locus;Genotype;Guidelines;Health;Health Personnel;Hemorrhage;High Prevalence;high risk;High Risk Woman;hormonal contraception;Hormone use;Hormones;Human;Human Genome;hypothalamic pituitary ovarian axis;Impairment;Implant;Individual;Individual Differences;individual response;inter-individual variation;Intrinsic factor;Investigation;life span;Literature;Matched Case-Control Study;Measurement;Medicine;men;Metabolism;Moods;novel;Oral Contraceptives;Other Genetics;Outcome;Ovarian Follicle;Ovulation;Ovulation Inhibition;Participant;Patients;personalized medicine;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Phenotype;phenotypic data;pill;Postmenopause;precision medicine;Prevalence;Prodrugs;Progesterone;Progestins;prospective;Questionnaires;recruit;reproductive;Research;response;Risk;Safety;Serum;Sex Hormone-Binding Globulin;side effect;steroid hormone;steroid hormone metabolism;Surrogate Markers;Testing;tool;unintended pregnancy;Variant;Woman;women patients;Women's Health;Work

PROJECT_TITLE: Influence of genetic variants on the pharmacokinetics and pharmacodynamics of combined oral contraceptive pill users

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: T32 Narrative This application is for renewal of a training program that will provide support for predoctoral and postdoctoral trainees performing cardiovascular research at the University of Hawaii.

PI_NAMEs: TALLQUIST, MICHELLE D (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Training in Cardiovascular Research at the University of Hawaii

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (O2)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rural Health;Stroke;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Stroke is the 5th leading cause of mortality in the US and the leading cause of adult disability and thus constitutes a major public health burden. Utah Stroke Net is one of 27 Regional Coordinating Centers that form the national NIH-sponsored Stroke Trials Network (Stroke Net). Utah Stroke Net aims to assist in development, promotion, and provision of the highest quality clinical stroke trials in stroke prevention, treatment, and recovery to patients across the Mountain West, whether urban, rural, or frontier.

PI_NAMEs: MAJERSIK, JENNIFER JUHL (contact)

PROJECT_TERMS: Academic Medical Centers;Active Learning;Address;Adult;Advocate;Affect;Arizona;Biomedical Engineering;Blood Vessels;career;career development;Caring;Childhood;Childhood stroke;Cities;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Colorado;Communities;community engagement;Contracts;cost;Coupled;Creativeness;data quality;Databases;Development;disability;Discipline;Education;effectiveness trial;electronic data capture system;Enrollment;Ensure;Environment;Equity;Etiology;experience;extracellular;Faculty;Female;Financial Support;Fostering;Foundations;frontier;Funding;Geography;Goals;Grant;Health;Health system;Hospitals;Human;Idaho;Image;imaging biomarker;Immune system;improved;Individual;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Interdisciplinary Study;Intervention;investigator training;Investments;Ischemic Stroke;Laboratories;Leadership;Link;Medical;Mentors;Methodology;Methods;minority patient;Montana;mortality;Motivation;multidisciplinary;Mus;National Institute of Neurological Disorders and Stroke;Network Infrastructure;Neurology;Neurosciences Research;neutrophil;novel;operation;Participant;participant enrollment;participant retention;patient engagement;patient population;Patient Recruitments;Patient Representative;Patients;Pediatric Hospitals;Performance;performance site;personalized strategies;Persons;Platelet Activation;Population Heterogeneity;Positioning Attribute;post stroke;post stroke depression;Postdoctoral Fellow;pre-clinical;Prevention;Principal Investigator;Process;Productivity;programs;promote resilience;Protocols documentation;Psychology;Public Health;randomized trial;Recovery;recruit;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rural;rural area;Rural Community;rural patients;Scholars Program;Science;screening;Site;skill acquisition;Standardization;Stroke;stroke clinical trials;stroke model;stroke outcome;stroke patient;Stroke prevention;stroke trials;success;Surveys;symposium;telehealth;teleneurology;telestroke;tool development;Training;Training Programs;translational neuroscience;Translational Research;translational scientist;trial design;trial enrollment;trial readiness;Underrepresented Minority;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Utah;Venous blood sampling;Vertebral column

PROJECT_TITLE: UT StrokeNet


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Both germline and somatic alterations contribute to the development of kidney cancer, though how these processes biologically converge to promote oncogenesis and evolution is incompletely understood. Through integrative and hypothesis-driven computational, functional, and clinical approaches, we will dissect related germline and somatic events in kidney cancer to yield novel and translatable discoveries.

PI_NAMEs: VAN ALLEN, ELIEZER M (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;Alleles;Biological;Biological Process;cancer cell;cancer diagnosis;cancer genetics;cancer genomics;Catalogs;Chromatin;Clear cell renal cell carcinoma;Clinical;clinical predictors;clinically actionable;clinically relevant;Code;cohort;Complex;Data;deep learning;deep learning algorithm;Development;Ensure;Equity;Event;Evolution;Exhibits;gene discovery;Genes;Genetic Transcription;Genome;genome analysis;genome wide association study;Genomics;Germ Lines;Germ-Line Mutation;Heterogeneity;Histologic;Histology;Image;innovation;Investigation;Lead;Link;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Methodology;Molecular;Mutation;neoplastic cell;nephrogenesis;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;precision oncology;Predictive Value;prognostic;prognostic value;Property;protein complex;rare condition;Recurrence;Renal Carcinoma;risk variant;Shapes;Somatic Mutation;Testing;tumor;tumor heterogeneity;tumor initiation;Tumor Promotion;tumorigenesis;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Dissecting Convergent Somatic and Germline Alterations that Mediate the Origins and Evolution of Kidney Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Multi-cancer detection tests are becoming commercially available, yet little is known about their feasibility, acceptability, and effectiveness for cancer screening in practice. This application is to establish an Accrual, Enrollment, and Screening Site Hub embedded across 21 medical centers in urban, suburban, and semi-rural populations within a large and diverse integrated health care system with comprehensive data capture. This setting, with a proven ability for effective recruitment in large cancer screening trials, will support efforts of the National Cancer Institute’s Cancer Screening Research Network to evaluate early cancer detection tests within diverse populations.

PI_NAMEs: LEE, JEFFREY KUANG ZOU (contact);NGO-METZGER, QUYEN ;SAKODA, LORI

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Accounting;Address;Adherence;Adult;Advanced Malignant Neoplasm;Age;Anxiety;Asian;Biological;Black race;Blood;Breast;California;Cancer Burden;Cancer Detection;cancer type;Caring;Cause of Death;cell free DNA;Cervix Uteri;Cessation of life;Clinical;Clinical Data;Collaborations;Colon Carcinoma;Communication;Data;data acquisition;Data Coordinating Center;data management;Databases;detection test;Diagnosis;Diagnostic;Early Diagnosis;early screening;Early treatment;effective therapy;Effectiveness;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Evaluation;experience;follow-up;frontier;Funding;Goals;Guidelines;health care service utilization;health care settings;health plan;Healthcare Systems;Hispanic;improved;Individual;ineffective therapies;Information Systems;Insurance;integrated care;Integrated Health Care Systems;Knowledge;Laboratories;Leadership;Link;Lung;Malignant Neoplasms;Medicaid;Medical center;medical specialties;Medicare;Methods;Monitor;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;National Cancer Institute;neoplasm registry;operation;Outcome;outreach;Pacific Islander;Participant;Pathology;Pathway interactions;patient oriented;Patient Recruitments;Patients;Population;Population Heterogeneity;Positioning Attribute;Positive Test Result;prevent;Prevention;primary care provider;Procedures;Process Assessment;prospective;Provider;Radiology Specialty;Recommendation;recruit;Research;Research Personnel;response;Risk;rural area;Rural Population;sample collection;Sampling;screening;Screening for cancer;screening guidelines;Site;sociodemographics;Specimen;standard of care;statistics;Structure;suburb;Test Result;Testing;Time;Tumor stage;Underrepresented Populations;United States

PROJECT_TITLE: Multi-Ethnic Multi-Cancer Early Detection and Screening (MED SCREEN) Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Repetitive transcranial magnetic stimulation (rTMS) is FDA cleared for treating depression that does not respond to antidepressant medication. Despite being a brain-based treatment, there is a gulf between knowledge from the brain imaging literature and how rTMS treatment is generally applied. We seek with this project to support a link between TMS evoked brain responses recorded during interleaved TMS/fMRI sessions and depression improvement to rTMS treatment.

PI_NAMEs: OATHES, DESMOND  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acceleration;Address;Aftercare;Anterior;anti-depressive agents;arm;Automobile Driving;Benchmarking;Brain;brain based;Brain imaging;brief intervention;Cementation;cingulate cortex;Clinical;clinical effect;Clinical Research;cohort;Coupling;Data Set;Electric Stimulation;Enrollment;Exclusion;Failure;Functional Magnetic Resonance Imaging;improved;Individual;Intervention;Investigational Therapies;Knowledge;Link;Literature;Measures;Mental Depression;Modality;neuroregulation;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;predicting response;Randomized;remediation;repetitive transcranial magnetic stimulation;Research;Resistance;response;Rest;Sampling;Scalp structure;Site;Surface;symptomatic improvement;Symptoms;Testing;Transcranial magnetic stimulation;treatment strategy;Work

PROJECT_TITLE: Engaging the subgenual cingulate with brain stimulation for depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-B (01)]


PHR: Project Narrative StrokeNet is the most exciting network in the world for identifying, nurturing, and advancing therapies for stroke. SPIRIT brings to StrokeNet a large patient population, rich in ethnic and racial diversity. SPIRIT will serve our community and train the next generation of academic stroke leaders.

PI_NAMEs: ALBERTS, MARK JAY;FURIE, KAREN L;SHETH, KEVIN NAVIN (contact);TEMES, RICHARD ELIAS

PROJECT_TERMS: Acceleration;Acute;Adult;Agreement;American Heart Association;Area;Blood Vessels;care systems;Characteristics;Childhood;Childhood stroke;clinical care;Clinical Management;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;Collaborations;collaborative environment;Communication;Communities;community engagement;Community Hospitals;Connecticut;Continuity of Patient Care;COVID-19 pandemic;Creativeness;Critical Care;Data Coordinating Center;data sharing;design;Development;Discipline;Education;electronic medical record system;Emergency Department Physician;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Faculty;Funding;Future;Generations;Geographic Locations;Goals;Health;health equity;Health system;Healthcare;Hospitals;Human Subject Research;Infrastructure;innovation;Institution;Institutional Review Boards;International;Lead;Leadership;Long Island;Magnetic Resonance Imaging;Massachusetts;Medical Records;medical schools;member;Mentors;Mission;Modeling;Modernization;Monitor;Multicenter Studies;Multicenter Trials;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologist;Neurology;Neurosurgeon;New England;New York;next generation;operation;patient engagement;patient oriented research;patient population;Patients;Pediatric Hospitals;Persons;Policies;Prevention;Principal Investigator;programs;Protocols documentation;Quality Control;Race;racial diversity;Records;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Resource Sharing;Rhode Island;Rural;rural setting;Science;Scientist;Services;Specialist;Stroke;stroke clinical trials;stroke patient;stroke therapy;stroke trials;Structure;success;Sum;synergism;System;Talents;tool;Training;Translational Research;United States;United States National Institutes of Health;Universities;urban setting;Vision;Work

PROJECT_TITLE: Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: No modifications to Public Health Relevance References 1. Christoffersson, G., Coppieters, K.T., von Herrath, M.G., and Homann, D. (2022). Autoimmunity and Autoimmune Diseases. In Paul’s Fundamental Immunology, M. Flajnik, N.J. Singh, and S.M. Holland, eds. (Lippincott Williams & Wilkins). 2. Atkinson, M.A., Eisenbarth, G.S., and Michels, A.W. (2014). Type 1 diabetes. Lancet 383, 69-82. 10.1016/S0140-6736(13)60591-7. 3. Chiang, J.L., Kirkman, M.S., Laffel, L.M., Peters, A.L., and Type 1 Diabetes Sourcebook, A. (2014). Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care 37, 2034-2054. 10.2337/dc14-1140. 4. Pociot, F., and Lenmark, A. (2016). Genetic risk factors for type 1 diabetes. Lancet 387, 2331-2339. 5. Rewers, M.J., and Ludvigsson, J. (2016). Environmental risk factors for type 1 diabetes. Lancet 387, 2340-2348. 6. Lind, M., Svensson, A.M., Kosiborod, M., Gudbjornsdottir, S., Pivodic, A., Wedel, H., Dahlqvist, S., Clements, M., and Rosengren, A. (2014). Glycemic control and excess mortality in type 1 diabetes. N Engl J Med 371, 1972-1982. 10.1056/NEJMoa1408214. 7. Insel, R.A., Dunne, J.L., Atkinson, M.A., Chiang, J.L., Dabelea, D., Gottlieb, P.A., Greenbaum, C.J., Herold, K.C., Krischer, J.P., Lernmark, A., et al. (2015). Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38, 1964-1974. 10.2337/dc15-1419. 8. Battaglia, M., Anderson, M.S., Buckner, J.H., Geyer, S.M., Gottlieb, P.A., Kay, T.W.H., Lernmark, A., Muller, S., Pugliese, A., Roep, B.O., et al. (2017). Understanding and preventing type 1 diabetes through the unique working model of TrialNet. Diabetologia. 10.1007/s00125-017-4384-2. 2. Atkinson, M.A., Eisenbarth, G.S., and Michels, A.W. (2014). Type 1 diabetes. Lancet 383, 69-82. 10.1016/S0140-6736(13)60591-7. 3. Chiang, J.L., Kirkman, M.S., Laffel, L.M., Peters, A.L., and Type 1 Diabetes Sourcebook, A. (2014). Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care 37, 2034-2054. 10.2337/dc14-1140. 4. Pociot, F., and Lenmark, A. (2016). Genetic risk factors for type 1 diabetes. Lancet 387, 2331-2339. 5. Rewers, M.J., and Ludvigsson, J. (2016). Environmental risk factors for type 1 diabetes. Lancet 387, 2340-2348. 6. Lind, M., Svensson, A.M., Kosiborod, M., Gudbjornsdottir, S., Pivodic, A., Wedel, H., Dahlqvist, S., Clements, M., and Rosengren, A. (2014). Glycemic control and excess mortality in type 1 diabetes. N Engl J Med 371, 1972-1982. 10.1056/NEJMoa1408214. 7. Insel, R.A., Dunne, J.L., Atkinson, M.A., Chiang, J.L., Dabelea, D., Gottlieb, P.A., Greenbaum, C.J., Herold, K.C., Krischer, J.P., Lernmark, A., et al. (2015). Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38, 1964-1974. 10.2337/dc15-1419. 8. Battaglia, M., Anderson, M.S., Buckner, J.H., Geyer, S.M., Gottlieb, P.A., Kay, T.W.H., Lernmark, A., Muller, S., Pugliese, A., Roep, B.O., et al. (2017). Understanding and preventing type 1 diabetes through the unique working model of TrialNet. Diabetologia. 10.1007/s00125-017-4384-2.

PI_NAMEs: HOMANN, DIRK  (contact);SPEAKE, CATE

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Affect;American;Antibody Response;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Process;Biological Assay;Biological Markers;Blinded;Blood Glucose;blood glucose regulation;Blood specimen;Budgets;carbohydrate metabolism;Caring;case control;Cells;Clinical;cohort;commensal bacteria;Complement;Complex;Continuous Glucose Monitor;Data;Data Analyses;data dissemination;data integration;data mining;data resource;Data Set;design;Development;diabetes management;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Diagnostic;Disease;Disease Pathway;Disease Progression;distributed data;Endocrine;Environmental Risk Factor;Event;Evolution;Excess Mortality;Exclusion;Exocrine pancreas;Family;Fostering;Funding;Future;Generations;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;genome-wide;glycemic control;Glycosylated hemoglobin A;Heterogeneity;high throughput analysis;Hormones;Immune;Immune response;Immunologic Markers;Immunologics;Immunology;improved;Incidence;Individual;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin Infusion Systems;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Studies;Investigation;islet;Kidney Failure;life span;lipid metabolism;longitudinal dataset;Measurement;Mediating;metabolome;Metadata;MicroRNAs;Modality;Modeling;Modification;Myocardial Infarction;Natural History;Nested Case-Control Study;novel;novel marker;Outcome;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Positioning Attribute;potential biomarker;Prevalence;prevent;Prevention;prognostic;prohormone;prophylactic;protein metabolism;psychologic;Public Health;public health relevance;Records;Research;Research Design;Research Personnel;Risk;risk stratification;sample collection;Sampling;Secure;Series;Serum;Serum Proteins;Societies;Staging;Stratification;Stroke;Structure of beta Cell of islet;Study of serum;Symptoms;Technology;technology platform;Therapeutic;therapy development;Time;transcriptomics;Treatment Protocols;United States;Validation;Viral

PROJECT_TITLE: The KQ1 serum study: soluble biomarkers for T1D risk, development & progression


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project narrative  This study will elucidate a novel pathway regulated by the putative interaction of MDM2 with α/β tubulins in promoting AML cell proliferation and chemotherapy resistance. Furthermore, we will evaluate a potential therapeutic role for VERU-111 in targeting the MDM2-α/β tubulin interaction using this clinically available tubulin inhibitor for precision treatment of refractory/MDM2-overexpressing AML patients.

PI_NAMEs: GRAHAM, DOUGLAS K;ZHOU, MUXIANG  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;alpha Tubulin;analog;Anthracycline;Behavior;beta Tubulin;Binding;cancer cell;cancer clinical trial;cancer drug resistance;cancer therapy;carcinogenesis;Cell Death;Cell Death Induction;cell growth;Cell model;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Chemoresistance;chemotherapy;Child;Clinical;clinical efficacy;Code;Colchicine;Cytarabine;Cytoplasm;Cytotoxic agent;Data;design;Development;Disease Progression;Down-Regulation;Drug resistance;Drug Targeting;Goals;Health;Hematological Disease;Human;improved;inhibitor;Knowledge;Leukemic Cell;Malignant Neoplasms;MDM2 gene;Mediating;Metastatic Prostate Cancer;Microtubules;Mus;mutant;N-terminal;novel;Oncogenes;Oncogenic;Oral;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Phase I Clinical Trials;Phase III Clinical Trials;Play;polymerization;Polymers;Post-Translational Protein Processing;potential biomarker;Precision therapeutics;preclinical study;Property;Quality of life;Refractory;Regulation;Resistance;Role;Sampling;side effect;Signal Pathway;Site;small molecule;small molecule inhibitor;Survival Rate;Survivors;targeted biomarker;targeted treatment;Testing;Therapeutic;therapeutic target;Toxic effect;TP53 gene;Transactivation;Treatment outcome;treatment response;Tubulin;Tubulin Interaction;tumor progression;tumorigenesis;Ubiquitination;Xenograft Model

PROJECT_TITLE: Discovery of a novel MDM2-tubulin signaling pathway as a therapeutic target in AML

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Human Genome;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Individuals born prematurely are at increased risk for asthma, the origins of which can be traced back to factors set at and even prior to the time of birth. Better understanding these influences may lead to opportunities for earlier diagnosis, improved treatment, or even prevention of asthma. The proposed research will address previously uncharacterized role of placental gene regulation and expression, and how that interacts with biological sex in leading to the onset of asthma during childhood among a cohort of children born extremely preterm.

PI_NAMEs: GOWER, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 10 year old;Address;Adolescence;Adult;Affect;Asthma;asthma prevention;Back;Biogenesis;biological sex;Birth;Blood;Blood Cells;boys;Cellular biology;Child;Childhood;Childhood Asthma;Chronic;Chronic Disease;chronic respiratory disease;cohort;Complex;Data;Data Set;Development;Diagnosis;DNA Methylation;Early Diagnosis;early life exposure;Environment;Environmental Exposure;Epigenetic Process;epigenome;Etiology;Exhibits;experience;Exposure to;extreme prematurity;Extremely low gestational age newborn;Fetal Development;Fetal Growth;Fetus;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genomic DNA;Gestational Age;Growth;Immune;Immune response;Immune system;improved;Individual;Infant;Inflammation;Inflammatory;insight;Investigation;late life;Leukocytes;Life;Link;Lung;Methylation;methylation pattern;MicroRNAs;Modification;Morbidity - disease rate;mortality;Mothers;mRNA Expression;multiple omics;Neonatal;neonatal immune system;neonate;novel;offspring;Organ;Organogenesis;Outcome;Pathway interactions;Pattern;Perinatal;Placenta;Play;Population;postnatal;Pregnancy;premature;Premature Birth;prenatal;prenatal exposure;Prevalence;Prevention;Process;Production;Puberty;Publishing;Research;Research Personnel;Respiratory Disease;Risk;Risk Assessment;Role;sex;Sex Differences;sexual dimorphism;Source;Time;Tissues;tool;translational study;transmission process;Umbilical Cord Blood;Umbilical cord structure;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Asthma among children born extremely preterm: multi-omic perinatal predictors

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Prevention

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Multi-cancer detection assays offer new opportunities to screen for many different cancers that currently have limited options for early detection; the Cancer Screening Research Network (CSRN) will conduct definitive clinical trials and studies to evaluate these assays. We bring together statistical leaders and database systems experts with experience in major clinical trials networks who have expertly designed, implemented, analyzed, and reported cancer screening, prevention, and treatment trials and studies, in collaboration with clinicians, scientists, patient advocates and other experts. The Statistics and Data Management Center (SDMC) of the CSRN will offer a rigorous system for CSRN trial design, management and analysis so that the information generated by CSRN trials forms a sound basis for national cancer screening policy.

PI_NAMEs: FENG, ZIDING ;GUTHRIE, KATHERINE ADAMS;KOOPERBERG, CHARLES L (contact)

PROJECT_TERMS: Address;Advocate;Benefits and Risks;Biological Assay;Cancer Detection;cancer type;Cessation of life;Clinical;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collaborations;Collection;Communication;Complex;cost;cost efficient;Data;Data Collection;data communication;Data Coordinating Center;data management;data quality;data quality/integrity;data resource;data submission;Database Management Systems;design;detection assay;detection test;Development;Early Detection Research Network;Early Diagnosis;Electronic Health Record;electronic health record system;Elements;Ensure;Equilibrium;Event;evidence base;experience;Expert Systems;Frequencies;Goals;Heterogeneity;Incidence;Information Systems;innovation;Knowledge;Malignant Neoplasms;Methodology;Multicenter Trials;Natural History;non-compliance;novel;operation;Outcome;Participant;Patients;Pilot Projects;Policies;Population;Prevention trial;Privacy;Procedures;Process;Production;Randomized;recruit;Reliability of Results;Reporting;Research;Research Design;Resources;Risk;Sample Size;scale up;Scientist;screening;Screening for cancer;screening policy;Secure;Services;sound;Southwest Oncology Group;Specimen;Statistical Methods;statistics;System;Testing;Time;Training;treatment trial;trial design;United States National Institutes of Health;Update;Women's Health;Work

PROJECT_TITLE: Statistics and Data Management Center (SDMC) for the NCI Cancer Screening Research Network (CSRN)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE An deficit in understanding of the molecular events that contribute to the development of age-related macular degeneration represents an obstacle to the design and implementation of therapeutics that more fully address its molecular pathogenesis. The present application will identify a novel mechanism that contributes to the failed antioxidant and inflammatory responses in retinal pigment epithelium with aging. These findings are expected to provide new targets for intervention and lead to the development of innovative therapies that target a leading cause of blindness.

PI_NAMEs: DENNIS, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute-Phase Proteins;Address;Age related macular degeneration;Aging;Antioxidants;biological adaptation to stress;Blindness;chemokine;Choroid;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;Complication;cytokine;Defect;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;disulfide bond;DNA Damage;Epithelium;Event;Exclusion;Feeds;Functional disorder;Gene Chips;Gene Expression;gene product;Genes;glycogen synthase kinase 3 beta;human induced pluripotent stem cells;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;Innovative Therapy;insight;Intervention;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Laboratories;macular edema;Mediating;Mesenchymal;Messenger RNA;Modeling;Molecular;mouse model;Mus;NF-kappa B;novel;Nuclear;nuclear factor-erythroid 2;old mice;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathology;Patients;Photoreceptors;Play;Point Mutation;pre-clinical;Pre-Clinical Model;prevent;Production;protein expression;Proteins;Proteolysis;Resistance;response;Retina;Retinal Defect;Retinal Degeneration;Retinal Diseases;Role;sensor;Signal Transduction;Small Interfering RNA;sodium iodate;Structure of retinal pigment epithelium;targeted treatment;Testing;Therapeutic;therapeutic target;Thinness;transcription factor;Transcriptional Activation;transdifferentiation;Transgenic Organisms;Variant;Vision;visual dysfunction;Visual impairment

PROJECT_TITLE: Unifying Mechanism of Oxidative Stress and Inflammation in AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_NAME: SANGUINA, LLC

PHR: PROJECT NARRATIVE Anemia, the most common blood disease that affects over 1.6 billion people worldwide, currently requires a clinic or hospital-based blood count for diagnosis. We have recently developed a novel, multi-faceted anemia screening and monitoring suite of products comprising 3 key products for home testing: 1) AnemoCheck Home test kit (under FDA interactive review)– a “single drop of blood” fingerstick test that utilizes our clinical FDA- cleared technology to elicit a color change that correlates with degree of anemia, 2) AnemoCheck app – a smartphone app that screens for anemia using only smartphone photos and the phone itself with no additional equipment and 3) AnemoCheck MyMobile– a marriage of the AnemoCheck Home test kit and AnemoCheck app products in which the app is “personalized” for each patient to significantly improve accuracy and enable self-monitoring of anemia. In this proposal, we aim to expand upon testing in Phase II answering to a request for additional data from FDA to 1) conduct human factors validation 2) implement quality control features and changes in workflow informed by human factors and 3) characterize the performance of AnemoCheck MyMobile head to head against comparator, reference method and when trained with AnemoCheck Home (versus a traditional blood test to train AnemoCheck MyMobile, versus traditional blood testing) for chronic anemia management to expand our use and allow for a completely home-based access to cost-effectively empower patients to manage their own care.

PI_NAMEs: TYBURSKI, ERIKA AMY (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Adult;Affect;algorithm training;Algorithms;Anemia;Beds;Biological Assay;Blood;Blood Tests;Calibration;Cardiovascular system;Caring;Cellular Phone;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;clinical research site;Clinics and Hospitals;cohort;Collaborations;Color;Communication;Complete Blood Count;Computer software;Cooley's anemia;cost;Data;Death Rate;design;Detection;Devices;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;diagnostic tool;Drops;empowerment;Epidemiology;Equipment;Equity;Etiology;Familiarity;Fatigue;Fingers;Foundations;Funding;gastrointestinal;Goals;Head;Health;Hematological Disease;Hematology;Hemoglobin;Hemoglobin concentration result;high risk;Home;home test;Human;Human Resources;Image;improved;improved outcome;individual patient;Journals;Left;Life;Link;Malignant Neoplasms;Malnutrition;Marketing;Marriage;Measurement;Measures;meter;Methods;Monitor;Morbidity - disease rate;Nature;novel;Outcome;Output;Oxidation-Reduction;Patients;pediatric patients;Peer Review;Performance;personalized medicine;Persons;Phase;point of care;Population;Pregnant Women;Productivity;Public Health;Publishing;Quality Control;Quality of life;Reaction;Reagent;Recommendation;Recurrence;Risk;Risk Assessment;screening;self testing;Severities;Sickle Cell;Sickle Cell Anemia;Small Business Innovation Research Grant;smartphone application;Source;Structure of nail of finger;Symptoms;System;Technology;technology validation;Telephone;Testing;Thalassemia;Time;tool;Training;Translations;treatment response;Validation;validation studies;Visit

PROJECT_TITLE: Translation of a personalized, non-invasive smartphone app for hemoglobin monitoring for chronic anemia patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The goal of this application is to understand how DNA polymerase beta chooses the correct substrate for incorporation into DNA. This research will help us to understand how mutations arise in the genome.

PI_NAMEs: DOUBLIE, SYLVIE ;LORIA, JOSEPH P;SWEASY, JOANN B. (contact)

PROJECT_TERMS: adaptive immunity;Amino Acids;Automobile Driving;Base Excision Repairs;Binding;Biochemical;Biological;Biophysics;carcinogenesis;Cartoons;Catalysis;Cells;Chemistry;chemotherapeutic agent;Complex;Computing Methodologies;Data;Deoxyribose;Development;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Polymerase β;DNA Repair;DNA-Directed DNA Polymerase;Double Strand Break Repair;Electrostatics;Enzymes;Event;Evolution;Excision;Excision Repair;Fingers;flexibility;Fluorescence Resonance Energy Transfer;Free Energy;Generations;Genome;Genomic Instability;Goals;Human;human disease;Human Genome;immunological diversity;In Vitro;in vivo;insight;Investigation;Ionizing radiation;Kinetics;Lesion;Maintenance;Malignant Neoplasms;Mediating;Metabolism;metaplastic cell transformation;Molecular;Molecular Conformation;Movement;Mutagenesis;Mutation;Nature;Nitrogen;Nonhomologous DNA End Joining;Nucleotides;oxidative DNA damage;Oxygen;Pathway interactions;Physiological Processes;Play;Polymerase;Process;Property;protein purification;Publishing;Reaction;repaired;Research;Research Personnel;Ribonucleotides;Role;Sampling;Source;Study models;tripolyphosphate;Ultraviolet Rays;V(D)J Recombination;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Fidelity Mechanisms of DNA Polymerase Beta

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Stroke

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The proposed Stroke Belt StrokeNet (SBSN) RCC has a robust network of institutions with access to a large population of potential subjects, many of them minorities, in an underserved part of the US, a track record of successful enrollment in stroke clinical trials, a rich community of basic science and translational stroke researchers, and an extraordinarily collaborative environment with the desire to contribute to the Stroke Net effort.

PI_NAMEs: GROPEN, TOBY  (contact);HARRIGAN, MARK ROBERT;LAZAR, RONALD M

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Academy;Acute;Adoption;Advisory Committees;Alabama;aphasia recovery;Area;Award;Basic Science;care systems;cerebrovascular;Child;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;Communities;Data Analyses;data management;data quality;Development;Drops;Enrollment;Ensure;Epidemiology;equity, diversity, and inclusion;experience;Faculty;Health Disparities Research;health disparity;Heart;human subject;Image;implementation science;improved;Incentives;Infrastructure;Institution;Investigation;Knowledge;Medical center;Minority;minority communities;Minority Groups;minority health;minority health disparity;minority patient;Mississippi;Modeling;mortality;motor recovery;neuroimaging;Neurologist;Neurology;Neurosurgeon;neurosurgery;next generation;operation;Patients;payment;Performance;Phase;Population;Populations at Risk;Prevention;programs;Protocols documentation;Public Health Schools;Quality Control;Randomized;Recovery;Rehabilitation therapy;Research;Research Personnel;research study;Research Support;Sampling;Science;Scientist;screening;Site;statistics;Stroke;Stroke Belt;stroke clinical trials;stroke recovery;stroke therapy;Structure;Training;Translational Research;Underrepresented Populations;United States;United States National Institutes of Health;Universities;University resources;willingness

PROJECT_TITLE: StrokeBelt StrokeNet

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]