NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: SARS-CoV-2, MERS-CoV and HCoV-OC43 represent three different betacoronavirus subgenera and cause a wide spectrum of disease from asymptomatic to upper respiratory to lethal pneumonia. The proposed study of betacoronavirus interactions with double-stranded RNA induced antiviral pathways and the PKR-like ER kinase (PERK) pathway will reveal a more comprehensive picture of virus-host interactions and how they are similar or different among the betacoronaviruses from different subgenera. This information will aid in developing antiviral strategies to target both host pathways and viral proteins, to combat current coronaviruses and to prepare for future coronavirus spillovers into humans.

PI_NAMEs: WEISS, SUSAN R (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;antagonist;attenuation;betacoronavirus;biological adaptation to stress;Biology;Cell Death;cell injury;Cells;combat;Coronavirus;coronavirus treatment;COVID-19 pneumonia;Cyclic AMP-Dependent Protein Kinases;Data;Disease;Disease Outbreaks;Double-Stranded RNA;endoplasmic reticulum stress;Endoribonucleases;experience;Feedback;Future;Genes;Genome;Goals;Human;human coronavirus;Immune;Immune response;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Innate Immune Response;interest;Interferons;Ligase;Lung;lung injury;Messenger RNA;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;mouse model;Mus;mutant;novel therapeutic intervention;oligoadenylate;Outcome;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptide Initiation Factors;Pharmaceutical Preparations;phosphoric diester hydrolase;Phosphorylation;Phosphotransferases;Pneumonia;prevent;Production;protein activation;Protein Biosynthesis;Protein Dephosphorylation;protein kinase R;Proteins;replicase;respiratory;Respiratory Disease;response;reverse genetics;Ribonucleases;RNA;Role;Sarbecovirus;SARS coronavirus;SARS-CoV-2 infection;Scheme;severe COVID-19;Signal Transduction;Structure;System;Therapeutic;Upper respiratory tract;Viral;Viral Genome;Viral Proteins;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Betacoronaviruses: activation and antagonism of host innate immune responses

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Transplantation

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Diabetes Endothelial Keratoplasty Study (DEKS): Impact of Diabetes on Corneal Transplant Success and Endothelial Cell Loss As individuals with diabetes comprise an increasing proportion of the donor cornea pool as well as the recipients of the donor tissue, questions continue to arise regarding the suitability of tissue from donors with diabetes for corneal transplantation, a major health concern considering nearly 50,000 tissues were distributed by United States eye banks and used for corneal transplants by United States surgeons in 2018. The DEKS will conduct a large, prospective, multi-center, masked clinical trial assigning corneas from donors with or without well characterized diabetes status to patients undergoing corneal transplantation, also characterized by diabetes status. The study will examine transplant success and the loss of endothelial cells after surgery, definitively determine the impact of donor and recipient diabetes on these outcomes, and thus help guide the eye banking and surgical community as to the safety and effectiveness of transplanting donor corneas from individuals with diabetes.

PI_NAMEs: LASS, JONATHAN H (contact);SZCZOTKA-FLYNN, LORETTA B

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Address;Adult;Advanced Glycosylation End Products;Adverse effects;Affect;aging population;American;Autopsy;Categories;Cause of Death;Cell Density;Cells;Clinical;Clinical Research;clinical research site;clinical trial enrollment;Clinical Trials;Communities;Cornea;Corneal Endothelium;Data;data repository;Descemet's membrane;diabetes management;Diabetes Mellitus;diabetes risk;diabetic;Donor person;Effectiveness;Endothelial Cells;Endothelium;Epidemic;Eye;Eye Banks;Eye Surgeon;Failure;Glycosylated hemoglobin A;Growth;Health;improved;Individual;Inferior;Keratoplasty;Light;Long-Term Effects;Masks;Measures;Methods;Multi-Institutional Clinical Trial;Newly Diagnosed;non-diabetic;novel;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Outcome;oxidation;Participant;Patients;Penetrating Keratoplasty;Population;Postoperative Period;pre-clinical;preservation;Price;primary endpoint;Procedures;prospective;Public Health;Reporting;Safety;Schedule;secondary analysis;Severities;Severity of illness;Skin;standard of care;Structure;success;Surgeon;Testing;Time;Time Study;Tissue Donors;Tissue Transplantation;Tissues;Transplantation;United States;Visual

PROJECT_TITLE: Diabetes Endothelial Keratoplasty Study(DEKS): Impact of Diabetes on Corneal Transplant Success and Cell Loss


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Chemical and Biology Interface (CBI) Training Program at University of Chicago trains students to work at the interface of chemistry and biology and to apply rigorous approaches with quantitative literacy to solve problems in biomedical science, equipping them with the scientific, communication, professional, and career navigating skills to make significant contributions to society in academic or research-related careers.

PI_NAMEs: KRISHNAN, YAMUNA ;PICCIRILLI, JOSEPH ANTHONY (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Predoctoral Training Program in Chemistry and Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The proposed work aims to elucidate the diverse set of activities employed by a class of viral proteins when degrading cellular factors to subvert the host’s immune defenses and enhance viral infectivity. The information obtained from this work will facilitate the design of new antiviral inhibitors for use in therapeutic control of HIV and other virus infections.

PI_NAMEs: XIONG, YONG  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: 3-Dimensional;Binding;Biochemical;Biophysics;Capsid Proteins;CD4 Positive T Lymphocytes;Cell Cycle Arrest;cellular targeting;Classification;cofactor;combat;Communities;Comparative Study;Complex;Cryoelectron Microscopy;Cyclophilin A;Cytidine Deaminase;Deamination;Degradation Pathway;design;Evolution;experimental study;factor A;Fluorescence;Goals;HIV;HIV-1;Host Defense Mechanism;Immune;Immune system;In Vitro;in vivo;Infection;inhibitor;insight;Integration Host Factors;Invaded;Knowledge;Mammals;Mediating;Methods;Molecular;multicatalytic endopeptidase complex;Mutagenesis;novel therapeutics;pathogen;Pathway interactions;Peptidylprolyl Isomerase;Phosphoric Monoester Hydrolases;PPP2R5A gene;Primate Lentiviruses;Protein Family;Protein Isoforms;Protein phosphatase;Proteins;reconstruction;recruit;Research;Research Design;Research Project Grants;Resolution;Reverse Transcription;Sheep;Spectrum Analysis;structural biology;Structure;System;Techniques;Therapeutic;tool;Transcript;transcription factor;Ubiquitin;ubiquitin-protein ligase;Validation;Viral;Viral Physiology;Viral Proteins;Virion;Virus Diseases;Virus Inhibitors;Virus Replication;Visna-maedi virus;Work;X-Ray Crystallography

PROJECT_TITLE: Multifaceted interactions between lentiviral Vif and host molecules for viral infectivity enhancement

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE: RELEVANCE TO PUBLIC HEALTH While there is general agreement that T effector cells of the adaptive immune system are important in controlling Alzheimer disease Aβ plaque removal, the role of T regulatory cells in controlling Aβ pathology is actively debated. We have found that T regulatory cells rely on mitochondria for energy while T effector cells utilize glycolysis, and that underlying mitochondrial defects predispose to Alzheimer disease and also regulate T regulatory cell capacity to modulate T effector cell antigen rejection. By combining our unique collection of mouse mitochondrial DNA variants with the classical APPswe predisposing AD mutant gene from the Tg2576 mouse, we propose to demonstrate the importance of mitochondrial variation in predisposition to Alzheimer disease and also to demonstrate how mitochondrial variation can modulate T regulatory cell regulation of T effector antigen rejection thus accounting for the variable results observed for T regulatory cells in Alzheimer disease mouse models.

PI_NAMEs: WALLACE, DOUGLAS C (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta oligomer;Ablation;Accounting;Adaptive Immune System;adaptive immunity;Adoptive Cell Transfers;Adoptive Transfer;Agreement;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid beta-Protein;Amyloidosis;Antigens;Antioxidants;Brain;brain parenchyma;cell injury;cell type;Cells;Central Nervous System;Chronic;Cognition;Cognitive;cognitive capacity;cognitive function;Collection;conditional mutant;Defect;Dementia;Disease;DNA;effector T cell;Enterobacteria phage P1 Cre recombinase;Etiology;Excision;FOXP3 gene;Genes;Glycolysis;Immune;immune function;Immune system;Impaired cognition;Impairment;Inflammation;Inflammatory Response;Interferons;Leukocytes;Licensing;Mediating;Memory;Microglia;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mouse model;Mus;mutant;Neurons;Nuclear;Oligopeptides;Oxidative Phosphorylation;Pathology;Peripheral;Physiology;Play;Predisposition;Production;Public Health;Reactive Oxygen Species;recruit;Regulatory T-Lymphocyte;Reporting;response;restoration;Role;Senile Plaques;Structure of choroid plexus;T cell regulation;Testing;Tg2576;Tissues;Transgenes;Transgenic Mice;Variant

PROJECT_TITLE: Role of Adaptive Immunity in Etiology of Alzheimer’s Disease andAlzheimer’s Disease-Related Dementias


ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Tuberculosis is a major global health burden, killing more than 1.5 million people every year, despite the availability of therapy. Finding more effective therapeutic strategies could transform the epidemic, but that will require a better understanding of the fundamental biology of bacterial growth, metabolism and interaction with the host of the causative agent – Mycobacterium tuberculosis (Mtb). This proposal aims to make advances toward this goal, utilizing innovative techniques to understand therapeutically relevant pathways in Mtb.

PI_NAMEs: EHRT, SABINE  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adult;Affect;Anabolism;Antibiotics;Bacteria;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biology;Biotin;Cell division;Cell Wall;cofactor;Collaborations;Complex;complex biological systems;Data Analyses;data dissemination;data sharing;Degradation Pathway;Development;Disease;Drug resistance;Environment;Enzymatic Biochemistry;Enzymes;Epidemic;Evolution;Fatty Acids;Genes;Genetic;genetic approach;global health;Goals;Growth;Infection;innovation;large scale data;lipid biosynthesis;lipidomics;Lipids;Mediating;Metabolic;Metabolism;metabolomics;Methodology;Methods;Modality;Molecular;Multi-Drug Resistance;Mutation;mycobacterial;Mycobacterium tuberculosis;New Agents;pathogen;Pathway Analysis;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Play;Post-Transcriptional Regulation;Process;programs;protein protein interaction;protein purification;Proteins;Research;Research Personnel;Resources;RNA;RNA Degradation;RNA Processing;Role;small molecule;Stress;stressor;synergism;System;Techniques;Therapeutic;therapeutically effective;Thinking;treatment response;Tuberculosis;Virulence;Work

PROJECT_TITLE: Pathway Analysis in Tuberculosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PROJECT_TERMS: Agreement;analytical tool;Biochemical;Biology;Communication;Complex;data sharing;Disease;Genetic;Goals;meetings;Methods;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;pathogen;Pathway Analysis;Pathway interactions;Persons;programs;Reporting;Research Personnel;Resolution;Resources;stressor;success;synergism;Technology;Teleconferences;Tuberculosis;Work

PROJECT_TITLE: Core D. Administration Core


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: OXFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MIAMI UNIVERSITY OXFORD

PHR: PROJECT NARRATIVE Osteoporosis and osteoporotic fractures continue to remain a clinical challenge that disproportionately affect females. Loss of ovarian function due to pre-mature ovarian failure or menopause are key underlying factors in the development of osteoporosis in women. Alternatives to traditional hormone therapy (estrogen alone or with progesterone) that can deliver hormones while reducing/eliminating safety risks such as cardiovascular disease or cancer would provide an alternative to existing pharmacological treatments including pharmacological hormone therapy and the bisphosphonates. We will assess the ability of a biomimetic ovarian cell encapsulation system developed by our team to regulate female endocrine hormone pathways in a manner that is safer and more effective at achieving bone health than pharmacological agents in a rat ovariectomy model. These studies will also allow determination of how the female endocrine regulatory pathways are impacted by the cell encapsulation strategy to yield these outcomes.

PI_NAMEs: BOYAN, BARBARA D.;OPARA, EMMANUEL C.;SAUL, JUSTIN  (contact);YAZDANI, SAAMI K

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Affect;Age;Age Years;Alendronate;Alginates;Allogenic;American;Animals;Anterior Pituitary Gland;Belief;Biomimetics;bisphosphonate;bone;bone health;cancer type;Cardiovascular Diseases;Cardiovascular system;Cell Separation;Cell Survival;Cell Therapy;cell type;Cells;Clinic;Clinical;clinical translation;confocal imaging;design;Development;Direct Costs;Disproportionately impacts women;Dose;egg;Encapsulated;Endocrine;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Estrogens;experimental study;Female;Follicle Stimulating Hormone;Fracture;gender difference;Gene Expression Profile;Glucocorticoids;Goals;granulosa cell;Heart;Histology;Hormone secretion;hormone therapy;Hormones;hospitalization rates;Human;Hypothalamic Hormones;Hypothalamic structure;Immune response;Immunologics;Implant;implantation;improved;in silico;In Vitro;Incidence;insight;Knowledge;loss of function;Luteinizing Hormone;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mechanics;men;Menopause;Messenger RNA;microCT;MicroRNAs;Modeling;Myocardial Infarction;next generation sequencing;older women;Oocytes;Oryctolagus cuniculus;Osteoporosis;Osteoporosis prevention;osteoporosis with pathological fracture;osteoporotic bone;Outcome;Ovarian;ovarian failure;Ovarian Follicle;Ovarian Granulosa Cell;Ovarian hormone;Ovarian Tissue;Ovariectomy;Ovary;Pathway interactions;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiological;Pituitary Gland;Pituitary Hormones;Plasma;polyornithine;Postmenopause;Premature Ovarian Failure;Prevalence;Progesterone;Rattus;Recommendation;Regulation;Regulatory Pathway;Research;Risk;Risk Reduction;Safety;safety outcomes;Source;Stroke;Structure;Surgical Models;System;Testing;theca cell;therapeutic target;Time;Tissue Engineering;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Uterus;Woman;Women's Health

PROJECT_TITLE: Sustained regulation of hypothalamus-pituitary-ovary hormones with tissue-engineered ovarian constructs as a treatment for osteoporosis in females

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: RHEE, KYU Y (contact)

PROJECT_TERMS: Biochemical;Biochemical Reaction;Biochemistry;Bioinformatics;Biological Assay;Cells;Collaborations;computerized data processing;Detection;Disease;Enzymes;gene function;Genes;Genetic Engineering;genetic manipulation;Goals;In Vitro;in vitro activity;Individual;insight;Link;lipidome;lipidomics;Lipids;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Methods;Molecular;Mycobacterium tuberculosis;Nucleic Acids;Nucleotides;Pathway Analysis;Pathway interactions;Physiological;Physiological Processes;Physiology;protein profiling;protein structure function;Proteins;Proteome;Proteomics;Publishing;Reagent;Recombinants;Research Project Grants;Resolution;small molecule;Source;stressor;Structure-Activity Relationship;System;Technology;tool;Tuberculosis;Untranslated RNA

PROJECT_TITLE: Core A. Metabolomics and lipidomics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: SACCHETTINI, JAMES C (contact)

PROJECT_TERMS: Adopted;assay development;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biology;Cloning;cofactor;Collaborations;design;Disease;Enzymatic Biochemistry;enzyme activity;Enzymes;Equipment;experience;Genetic;Goals;In Vitro;Individual;insight;Laboratories;Lead;macromolecule;member;metabolomics;Methods;Molecular;Mycobacterium tuberculosis;Open Reading Frames;overexpression;pathogen;Pathway Analysis;Pathway interactions;programs;protein expression;protein function;protein purification;Proteins;Publishing;Reaction;Recombinant Proteins;Recombinants;Recording of previous events;Resources;Stress;structural genomics;Structure;Testing;Tuberculosis;Work

PROJECT_TITLE: Core B. Biochemistry and Enzymology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

PROJECT_TERMS: Anabolism;Archives;Bioinformatics;Biological;Biological Assay;Biotin;Carbon;Cell division;Cell Physiology;chemical genetics;Collection;CRISPR interference;Critical Pathways;Data;data dissemination;data integration;Data Set;data sharing;Databases;Dedications;Deposition;design;differential expression;Disease;Essential Genes;experimental study;Genbank;gene function;Genes;Genetic;Genome;Growth;in vivo;Incubated;independent component analysis;Infection;Iron;knock-down;Knock-out;Libraries;M. tuberculosis genome;Machine Learning;machine learning algorithm;Metabolic;metabolomics;Methods;Modeling;Mus;mutant;Mycobacterium tuberculosis;neural network;new technology;novel;Ontology;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Play;predictive modeling;programs;protein function;protein purification;public repository;Regulon;Research Personnel;response;RNA Processing;Role;Source;Statistical Data Interpretation;Statistical Methods;Stress;Training;training data;transcriptome sequencing;transcriptomics;transposon sequencing;Tuberculosis;vector;web site;Work

PROJECT_TITLE: Core C. Bioinformatics and data sharing.


PROJECT_TERMS: acid stress;Acids;Anabolism;Antibiotic Therapy;Automobile Driving;Biochemical;Biology;Carbon;caseating granulomas;Catabolism;cell envelope;Cell surface;Cells;Collaborations;Complex;Data;Defect;Disease;Dyes;Enzyme Interaction;enzyme pathway;Enzymes;experimental study;Exposure to;extracellular;fatty acid metabolism;Fatty Acids;Gene Expression Profiling;gene induction;Genes;Genetic;Goals;Granuloma;Growth;Immune response;Immunoprecipitation;In Vitro;Infection;Insertional Mutagenesis;Label;lipid biosynthesis;lipid metabolism;Lipids;M. tuberculosis genome;Macrophage;Maps;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;Multienzyme Complexes;mutant;Mycobacterium tuberculosis;Nature;next generation sequencing;novel;Nutritional;Pathogenesis;Pathway Analysis;Pathway interactions;Phagosomes;Phase;programs;Property;Proteins;Regulation;Resistance;resistance gene;Signal Transduction;Source;Stains;Stress;Structure;Testing;transcriptome sequencing;transmission process;Tuberculosis;Virulence;Work

PROJECT_TITLE: Project 1. Metabolic adaptations required for growth and virulence of Mtb at acidic pH.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE The impact of cannabis use (CU) on public health has become an increasingly pressing concern, particularly among emerging adults, who evidence tremendous plasticity in neurophysiological functioning but are at increased risk for both elevated rates of CU and trauma exposure. Little is known about how acute posttraumatic stress symptoms, as well as alterations in fear response and physiology, impact cannabis use behavior, especially during the days and weeks immediately following trauma exposure. The present investigation examines in vivo momentary and biological processes implicated in the development of negative outcomes of trauma including cannabis misuse and posttraumatic stress disorder among emerging adults during the acute posttrauma period.

PI_NAMEs: BRICK, LESLIE ANN DALINE (contact);NUGENT, NICOLE R

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Accident and Emergency department;Acute;acute stress;acute symptom;Admission activity;Adolescent;Adult;aged;Arousal;Automobile Driving;Belief;biological adaptation to stress;Biological Process;Cannabinoids;Cannabis;cannabis craving;cannabis use behavior;Chronic;Clinical;Coupled;Coupling;craving;critical period;Data;Development;Diagnosis;Disease;Distress;Early-life trauma;Ecological momentary assessment;emerging adult;endocannabinoid signaling;endogenous cannabinoid system;Evaluation;Exhibits;Exposure to;Extinction;fear memory;follow-up;Fright;Galvanic Skin Response;General Hospitals;Goals;Heart Rate;high risk;high risk population;Hospitals;Impairment;in vivo;indexing;Individual;Informal Social Control;insight;Interview;Investigation;Laboratory Procedures;Laws;Learning;Legal;Licensing;Link;Long-Term Effects;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Measures;Medical;Medical Marijuana;Memory;Modeling;Negative Reinforcements;neural circuit;Neurobiology;neurophysiology;Observational Study;Outcome;Output;Participant;Patient Self-Report;Phase;physical assault;Physiological;Physiology;Play;post-trauma;Post-Traumatic Stress Disorders;post-traumatic symptoms;pre-clinical research;Problem behavior;prospective;Prospective Studies;Psychotropic Drugs;Public Health;Qualifying;Recreational Drugs;recruit;Reporting;Research;response;Retrieval;Risk;Role;Safety;Self Medication;Severities;smart watch;Stress;substance use;Substance Use Disorder;Symptoms;System;Therapeutic;Time;Trauma;trauma exposure;Trauma recovery;trauma symptom;traumatic event;Traumatic injury;United States;US State;vehicular accident;wearable sensor technology;Work;young adult

PROJECT_TITLE: Cannabis use following trauma exposure: An observational study of the impact of acute stress and fear response on cannabis outcomes

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


PI_NAMEs: SCHNAPPINGER, DIRK  (contact)

PROJECT_TERMS: Acids;Address;Affect;amino acid metabolism;Anabolism;Biochemical;Biological;Biology;Biotin;Biotin Metabolism Pathway;Biotinylation;carboxylation;Cessation of life;Citric Acid Cycle;Classification;Coenzymes;cofactor;Collaborations;Decarboxylation;deprivation;Disease;drug development;Drug Targeting;Enzymes;experimental study;fatty acid biosynthesis;Fatty Acids;follow-up;Genes;Genetic;Goals;Growth;In Vitro;Infection;Kinetics;Ligation;Lipids;Liquid substance;Mus;mutant;mycobacterial;Mycobacterium tuberculosis;novel;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Predisposition;programs;Protein Inhibition;Proteins;Reaction;Recycling;response;Rifampin;Role;Starvation;Stress;stressor;synergism;Testing;transposon sequencing;Tuberculosis;tuberculosis chemotherapy;Vitamins;Work

PROJECT_TITLE: Project 2. Acquisition, synthesis and importance of biotin in Mtb.


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The role of lipid homeostasis in aging and Alzheimer’s disease (AD) is poorly understood, which is notable because lipid droplets (LDs) were included in the very first histological descriptions of brain tissue from patients with AD. We will produce the first high molecular specificity and high spatial resolution isomer-resolved lipidomic survey of brain regions and cell types involved in LD dysregulation as it relates to normal aging and AD. Using adaptive image fusion and machine learning methods, we will produce dense lipid fingerprints with regional and cell type specificity that will be incorporated into existing atlases and will be available to the community as a resource.

PI_NAMEs: SCOTT, ALISON J (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Adoption;Affect;Age;age effect;Aging;aging brain;aging mechanism;aging related disease;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Atlases;Awareness;Biological Assay;Brain;brain cell;Brain Mapping;Brain region;brain tissue;cell type;Cells;Characteristics;Cholesterol;Cholesterol Esters;combinatorial;Communities;Data;Diabetes Mellitus;Disease;disease model;Dose;Elements;Endotoxins;Failure;Female;Fingerprint;Gaucher Disease;Health;healthspan;healthy aging;Hippocampal Formation;Histologic;Histology;Homeostasis;Human;Image;Immunohistochemistry;Individual;Inflammation;interest;Intervention;Isomerism;Knowledge;Life;Link;lipid metabolism;lipid transport;lipidomics;Lipids;Liver Failure;Machine Learning;machine learning method;Maintenance;male;Maps;mass spectrometric imaging;Mass Spectrum Analysis;meter;Methods;Modeling;Molecular;mouse model;multimodality;Mus;Neighborhoods;Neurons;normal aging;novel;Organelles;Organism;Parkinson Disease;Pathology;Persons;phenotypic data;Phospholipids;Physiologic pulse;pi bond;Population;preservation;Production;Protein Isoforms;Proteins;Recycling;Regulation;Research;Resolution;Resources;Role;sex;Specificity;Sphingolipids;stable isotope;Stains;Surveys;Testing;Time;Tissues;tool;Transcriptional Regulation;transcriptomics;translational therapeutics;Triglycerides;United States;Wild Type Mouse

PROJECT_TITLE: Defining lipid droplet homeostasis in Alzheimer's disease and aging with high molecular specificity using mass spectrometry imaging and isomer resolved lipidomics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PROJECT_TERMS: acquired drug resistance;Activities of Daily Living;Address;Affect;Animal Model;Animals;antibiotic tolerance;Antibiotics;Binding;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biology;candidate identification;cell envelope;Cell model;Cell Physiology;Cells;Characteristics;Clinical;Clinical Pathways;Code;Collaborations;Complex;Data;data sharing;Degradation Pathway;design;Diagnostic;drug efficacy;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Drug Tolerance;Environment;Enzymatic Biochemistry;Enzymes;Event;Exonuclease;Gene Expression Regulation;Genes;Genetic;Genomics;Genus Mycobacterium;Goals;helicase;Immunoprecipitation;In Vitro;in vivo;in vivo Model;Infection;Knowledge;lipidomics;Maps;Mass Spectrum Analysis;Messenger RNA;Metabolic;metabolomics;Methodology;Modeling;mouse model;mRNA Decay;mRNA Transcript Degradation;Mus;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;new therapeutic target;novel therapeutics;overexpression;Pathway Analysis;Pathway interactions;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Population Study;pressure;Process;Prokaryotic Cells;protein degradation;protein function;Proteins;Regimen;ribonuclease E;Ribonuclease III;Ribonucleases;RNA Degradation;RNA Helicase;RNA metabolism;RNA Processing;Route;Shapes;Specificity;Structure;synergism;Testing;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;transposon sequencing;Treatment Failure;Tuberculosis;Variant;Work

PROJECT_TITLE: Project 3. Defining the RNA processing and degradation pathways of Mtb.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

PROJECT_TERMS: antimicrobial;Bacillus subtilis;Bacteria;Biochemical;cell assembly;Cell Cycle;Cell division;Cell Division Process;cell growth;Cell model;Cell Physiology;Cell Wall;Cellular Metabolic Process;Cellular Structures;Collaborations;Complex;Core Facility;Cues;Cytokinesis;Cytoplasm;Cytoplasmic Protein;Data;Disease;DNA biosynthesis;Enzymes;Escherichia coli;Event;gene product;Genes;Genetic;Genetic Transcription;Genus Mycobacterium;Goals;Guanosine;Infection;Link;Mediator;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;model organism;Morphogenesis;mycobacterial;Mycobacterium tuberculosis;Nucleosides;Pathway Analysis;Pathway interactions;periplasm;Phosphorylation;Process;programs;protein complex;Protein Kinase;protein protein interaction;quantitative imaging;Regulation;Role;segregation;Stress;synergism;Tuberculosis;Work

PROJECT_TITLE: Project 4. Defining cell division pathways in Mtb.


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This study will use novel methods and extensive data sources to: 1) Examine the relationship between regional exposure to structural racism (defined as: historic redlining) and present-day social risk factors, human capital, and health care resources; 2) examine the direct and indirect effects of regional exposure to structural racism on health outcomes via social risk, human capital, and healthcare resources; 3) assess policy levers of federal, state, and local governments that can be used to reduce area vulnerabilities to historic structural racism, and that can reduce present-day racial/ethnic disparity gaps in health outcomes; and 4) Engage a diverse set of key stakeholders to identify and prioritize strategies for mitigating social risk, building human capital, and improving health care resources and outcomes for regions exposed to structural racism through historical redlining.

PI_NAMEs: EGEDE, LEONARD E. (contact);LINDE, SEBASTIAN

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Area;Charge;Code;Color;Communities;Complex;cost;Data;Data Sources;Discrimination;Disparity;disparity gap;disparity reduction;economic disparity;economic need;Ensure;Equation;ethnic disparity;ethnic minority;Event;evidence base;explainable machine learning;Exposure to;Federal Government;food insecurity;Fostering;Goals;Government;Health;Health Care Costs;health care service utilization;health disparity;health outcome disparity;Healthcare;Hispanic;Home;Hospital Closures;Housing;housing instability;human capital;implementation strategy;improved;Individual;Inequity;innovation;Insurance;Investments;Knowledge;Legal;Link;Local Government;machine learning method;Maps;Measurement;Medicaid;Medical;Methods;Modeling;mortality;multilevel analysis;Neighborhoods;novel;Outcome;Pathway Analysis;Pathway interactions;Police;Policies;poor health outcome;programs;racial disparity;racial minority population;Residual state;Resources;Risk;Risk Factors;Safety;Schools;Security;skills;social;social health determinants;Societies;State Government;Statutes and Laws;Structural Racism;System;Time;voucher;Wages

PROJECT_TITLE: Structural Racism and Disparities in Social Risk, Human Capital, Health Care Resources, and Health Outcomes: A Multi-level Analysis of Pathways and Policy Levers for Change

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Individuals with a history of adverse childhood experiences (ACEs) are more likely to smoke cigarettes than those without, but little is known about the factors that account for this increased risk. This research will examine reward-related brain function and reactions to initial nicotine exposure to help explain why ACEs lead to increased risk for smoking. This research will also examine whether these processes differ between men and women.

PI_NAMEs: SWEITZER, MAGGIE M (contact)

PROJECT_TERMS: 21 year old;Accounting;addiction;Adolescent;Adult;adverse childhood events;Age;Animal Model;Behavioral;Behavioral Mechanisms;Behavioral Paradigm;Brain;childhood adversity;Cigarette;cigarette smoke;cognitive control;Corpus striatum structure;Dependence;depressive symptoms;design;Dopamine;Dose;drug of abuse;early life adversity;early life stress;experience;Exposure to;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Health;high risk population;Household;Human;Individual;Individual Differences;insight;Intranasal Administration;Laboratories;Laboratory Study;Lead;Link;Literature;Measures;Mediating;men;Methods;Modeling;neglect;neurobehavioral;Neurobiology;neuroimaging;neuromechanism;Nicotine;nicotine exposure;Nicotine Nasal Spray;nicotine use;non-smoker;non-smoking;Nose;Outcome;Participant;Pathway interactions;Physiological;Placebos;preference;Prevention;Procedures;Process;prospective;Protocols documentation;Psychological reinforcement;Reaction;Recording of previous events;Research;response;reward anticipation;reward processing;Rewards;Risk;Role;Severities;sex;Sex Differences;Smoker;Smoking;smoking exposure;smoking initiation;Smoking treatment;Socioeconomic Status;Stress;Substance Use Disorder;Testing;Time;Tobacco use;translational framework;Translations;Visit;Woman;Work;young adult

PROJECT_TITLE: Neurobehavioral mechanisms linking childhood adversity to increased risk for smoking

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Surging evidences support the notion that hypoperfusion is an early symptom in Alzheimer’s disease and related dementias (ADRD). However, the mechanism underlying hypoperfusion in ADRD remains to be determined. This project will use cutting-edge physiology imaging techniques, behavior-test methods, and immunohistochemistry to systematically investigate the pathophysiological mechanism of hypoperfusion in two representative mouse models of ADRD with both cross-sectional and longitudinal settings.

PI_NAMEs: WEI, ZHILIANG  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Age;Air;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloidosis;Anatomy;Animal Disease Models;Arterial Disorder;autosome;Behavior;behavior test;behavioral outcome;Biological Markers;Blood - brain barrier anatomy;Blood specimen;Blood Vessels;blood-brain barrier permeabilization;Brain;brain metabolism;CADASIL;candidate marker;Cell Density;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;cingulate cortex;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cohort;Contrast Media;Coupling;cranium;Cross-Sectional Studies;Data;Dementia;density;disease model;Enzyme-Linked Immunosorbent Assay;Euthanasia;fluorodeoxyglucose positron emission tomography;Funding;Genetic;glucose metabolism;Goals;Histologic;Histology;Human;Hypercapnia;hypoperfusion;Image;imaging study;Imaging Techniques;Immunohistochemistry;Impaired cognition;in vivo;indexing;inflammatory marker;Interleukin-6;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Memory;Metabolic;metabolic rate;Metabolism;Methods;Microvascular Dysfunction;Modeling;mouse model;Mus;Nature;Neurofibrillary Tangles;novel;object recognition;optical imaging;Oxygen;Participant;Pathology;Pattern;Perfusion;Physiological;Physiology;Positioning Attribute;processing speed;Proteins;Reporting;Reproducibility of Results;Research;Research Design;Research Personnel;Senile Plaques;Severities;Smooth Muscle Myocytes;Subcortical Infarctions;Subcortical Leukoencephalopathy;Symptoms;Tauopathies;Techniques;Testing;Therapeutic;Thinness;Tight Junctions;Time;TNF gene;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular Smooth Muscle;Wild Type Mouse;Work

PROJECT_TITLE: Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

PHR: NARRATIVE This study will determine neuronal vulnerability to lipid droplets (LD) and cholesterol, and the underlying molecular changes associated with Alzheimer's disease (AD) risk alleles. The results will significantly advance our understanding of how cell type-specific abnormal LD and cholesterol contribute to AD risk, which will help identify cellular biomarkers for AD progression and help develop more tailored lipid-based treatments.

PI_NAMEs: DUAN, JUBAO  (contact)

PROJECT_TERMS: Affect;Age;Aging;aging brain;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;apolipoprotein E-4;Astrocytes;ATAC-seq;Biological Assay;Biology;Brain Diseases;brain health;Cell Communication;Cell Differentiation process;Cell Line;Cell model;Cell Nucleus;Cell Proliferation;Cell Survival;cell type;Cells;Cellular Assay;Cerebrum;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Chromatin;Clinical;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Data;Dementia;dementia risk;Demyelinations;Disease;Disease Progression;effective therapy;epigenomics;excitatory neuron;Fatty Acids;Genes;Genetic;Genetic Risk;Genetic Transcription;genome wide association study;genome-wide analysis;Goals;Homeostasis;Human;human induced pluripotent stem cells;Image;Impairment;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Lesion;lipid metabolism;Lipids;Mediating;Microglia;Modeling;Molecular;multiple omics;myelination;Nerve Degeneration;nerve stem cell;neural;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuroprotection;neuropsychiatry;Nonesterified Fatty Acids;normal aging;oligodendrocyte progenitor;Oligodendroglia;Organoids;Outcome;Patients;Phenotype;Plasma;polygenic risk score;Proteins;receptor;remyelination;repaired;Research;risk variant;RNA;Role;Small Nuclear RNA;Stress;Synapses;tau Proteins;Toxic effect;transcriptomics;triacsin C;Triglycerides

PROJECT_TITLE: Neuronal Vulnerability to Lipid Droplets and Cholesterol in Alzheimer's Disease


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Invasive fungal infections are a global health problem. We have found that small soluble fungal ligands that are immunosilent in the periphery, become potent immunogens once they reach the draining lymph node (dLN) and outcompete the activity of classical adjuvants. Here, we hypothesize that the anatomical restriction to the dLN of the initial innate response elicited by soluble fungal ligands instructs a potent adaptive immune response. Also, that this response can be leveraged to protect against invasive fungal infections and anticipate that these studies will be foundational for developing novel and effective therapeutic interventions.

PI_NAMEs: ZANONI, IVAN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adjuvant;Affect;Allergic Disease;Anatomy;anti-fungal agents;Antibodies;Antibody Formation;Antigens;Attention;Autoimmune Diseases;autoimmune pathogenesis;B-Lymphocytes;Binding;Bypass;C Type Lectin Receptors;Candida;Candida albicans;candidemia;Candidiasis;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Data;design;Detection;Development;Disease;draining lymph node;Epithelium;Event;fungus;Gene Mutation;genetic signature;Genetic Transcription;global health;Goals;Health;Immune;Immune response;Immune system;Immunocompromised Host;Immunology;improved;Incidence;Individual;Infection;Infectious Agent;Inflammation;Inflammatory;inflammatory milieu;Innate Immune Response;Innate Immune System;innovation;insight;Interferon Type II;Interferons;Life;Ligands;Location;Lymph Node Subcapsular Sinus;Macrophage;Mediating;Medical;microbial;migration;Modeling;Modernization;Mycoses;NF-kappa B;novel;novel therapeutic intervention;Outcome;pathogen;Pathway interactions;Patients;Pattern recognition receptor;Peripheral;Persons;Phagocytes;physical property;Polysaccharides;Predisposition;prevent;Process;Production;protein function;relB protein;response;Role;Sentinel;Sepsis;Signal Transduction;Solubility;Stimulus;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;Vaccines

PROJECT_TITLE: Innate control of the inflammatory process during fungal infections

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

PHR: PROJECT NARRATIVE The basolateral amygdala (BLA) is a neural hub that receives diverse inputs that drive its ability to control fear and anxiety-related behaviors. A lack of understanding of how neuromodulatory signaling molecules control BLA function has hindered the development of effective therapeutic strategies. Here, we will use a battery of novel optical techniques to probe how specific G protein-coupled receptors modulate cortical inputs to the BLA and control fear and anxiety-related behaviors.

PI_NAMEs: LEVITZ, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;acute stress;Agreement;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;anxiety treatment;anxiety-related behavior;Auditory;Aversive Stimulus;avoidance behavior;Behavior;Behavior Control;Behavioral;Behavioral Mechanisms;behavioral response;behavioral study;Brain;Brain region;cell type;Cells;Chronic;Chronic stress;Clinical Data;comparative;Complex;conditioned fear;Consensus;Data;Development;Disease;Drug Targeting;Electrophysiology (science);Emotional;experimental study;Extinction;Family;feeding;Fiber;Fright;Future;G-Protein-Coupled Receptors;Genetic;genetic approach;Genetic study;hippocampal pyramidal neuron;Impairment;in vivo;insight;Interneurons;Learning;Link;Long-Term Depression;Maps;Measures;Medial;Mediating;Mediator;metabotropic glutamate receptor 2;Metabotropic Glutamate Receptors;Molecular;Mus;Nature;neural;Neurons;neuropsychiatric disorder;neuroregulation;novel;novel strategies;Opsin;Optics;optogenetics;Pathway interactions;Pattern;pharmacologic;Pharmacology Study;photoactivation;Photometry;Play;Post-Traumatic Stress Disorders;pre-clinical;Prefrontal Cortex;presynaptic;Process;Property;rapid technique;receptor;Regulation;response;Role;Shapes;Signaling Molecule;Slice;social;Social Interaction;somatosensory;spatiotemporal;Stress;Structure;Synapses;synaptic inhibition;Synaptic plasticity;System;Techniques;Testing;therapeutically effective;tool;transcriptome sequencing;treatment of anxiety disorders;Viral

PROJECT_TITLE: Photopharmacological interrogation of presynaptic neuromodulation of cortico-amygdalar circuits

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: MIAMI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project narrative We propose new multimodal imaging technologies based on a visible-light optical coherence tomography (VIS- OCT) platform to quantitatively image the fundus autofluorescence emitted by lipofuscin in the retinal pigment epithelium, and the spectral reflectance of the retinal nerve fiber layer. These novel imaging technologies will add a significant clinical tool for diagnosis, staging, and follow-up of retinal degenerative disorders and glaucoma, and will have a great impact on patient care and clinical trials for potential treatments.

PI_NAMEs: JIAO, SHULIANG  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: absorption;Address;Age;age group;Age related macular degeneration;Algorithms;animal imaging;Animals;Anterior;attenuation;Axon;Biological Markers;Calibration;Clinical;Clinical Research;Clinical Trials;clinically significant;Compensation;Confocal Microscopy;contrast imaging;Cytoskeleton;Data;Degenerative Disorder;Detection;Diagnosis;Disease;Early Diagnosis;Early treatment;Eye;Feedback;Fiber;Fluorescence;follow-up;frontier;Functional Imaging;Fundus;fundus imaging;Glaucoma;Goals;human imaging;human subject;Image;imaging study;Imaging technology;improved;Individual;interest;Learning;Light;Light Coagulation;Lipofuscin;Mass Spectrum Analysis;Measures;Melanins;Melanosomes;Modeling;Molecular;Monitor;Multimodal Imaging;multimodality;Nerve Fibers;new technology;Nonexudative age-related macular degeneration;novel;novel imaging technology;Ophthalmologist;Optical Coherence Tomography;Optics;Pathogenesis;Patient Care;Patients;Physiologic Intraocular Pressure;Polymethyl Methacrylate;Predisposition;quantitative imaging;Rattus;Reference Standards;Research;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;retinal nerve fiber layer;Signal Transduction;Slide;Solid;Source;Staging;Stains;Stargardt's disease;Structure of retinal pigment epithelium;System;Technology;Testing;Theoretical model;therapy development;Thick;Thinness;Time;titanium dioxide;tool;Trabecular meshwork structure;treatment strategy;Visible Radiation;Work

PROJECT_TITLE: Quantitative multimodal retinal imaging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Narrative Genes within humans and other mammals are marked with chemical tags that direct normal embryonic development. Assisted reproduction technologies that help infertile couples conceive may disrupted these chemical tags in resulting embryos. This research proposal will identify chemical signatures that discriminate embryos with and without errors and noninvasive approaches to distinguish between these embryos.

PI_NAMEs: MANN, MELLISSA RAE WIGLE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Assisted Reproductive Technology;Biological;Biological Markers;Biopsy;bisulfite;blastocyst;Cells;Chemicals;Child;Clinic;clinical practice;Couples;Data;Defect;Development;Disease;DNA Methylation;Embryo;embryo cell;embryo culture;Embryonic Development;Embryonic Induction;Epigenetic Process;Fetal Growth Retardation;Frequencies;General Population;Genes;Genetic;Genomic Imprinting;Germ Cells;Human;Impairment;Importins;imprint;improved;Incidence;Incubated;Infertility;infertility treatment;Knowledge;Lead;Low Birth Weight Infant;Maintenance;Mammals;Mediating;Medical;Methods;Methylation;Modality;Molecular Profiling;Mus;Mutagenesis;North America;Nuclear Import;nucleocytoplasmic transport;Oocytes;Oogenesis;Outcome;Pathway interactions;pharmacologic;Population;Prader-Willi Syndrome;Pre-implantation Embryo Development;predictive marker;Predisposition;preimplantation;Premature Birth;Procedures;protein degradation;Proteins;Proxy;Publishing;Regulation;Reporter;Reporting;Research Proposals;Risk;Screening procedure;Silver;Silver-Russell syndrome;single-cell RNA sequencing;Superovulation;Testing;Transcript;transcriptome sequencing;TRIM Gene;trophoblast;trying to conceive;Unsafe Sex;whole genome

PROJECT_TITLE: Identifying Molecular Signatures of Genomic Imprinting Errors

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Corneal scarring, a major corneal morbidity, is a major indication for corneal transplantation. Understanding the pathophysiology of corneal scar formation and establishing new nonsurgical therapeutic interventions will alter the prognosis and management of patients with corneal scarring.

PI_NAMEs: ESPANA, EDGAR MAURICIO (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Apoptosis;Area;Blindness;Bromodeoxyuridine;C57BL/6 Mouse;Chemicals;Cicatrix;Clinical;Collagen;Cornea;corneal scar;Corneal Stroma;Cues;Data;density;Deposition;Development;Disease;Down-Regulation;Environment;Extracellular Matrix;fibrillogenesis;Fibroblasts;Foundations;Functional disorder;Future;gene therapy;Goals;in vivo;in vivo Model;Infection;inhibitor;Injury;innovation;Integrin alphaV;Integrins;Intervention;Keratoplasty;Label;light scattering;mechanical properties;mechanical signal;Mechanics;Medical;Morbidity - disease rate;mouse model;Myofibroblast;Natural regeneration;novel;Operative Surgical Procedures;Pathologic Processes;Patients;Peripheral;Phase;Phenotype;Play;Process;Prognosis;Property;Public Health;Regulation;repaired;Research;Resistance;response to injury;Role;Secondary to;Severities;Signal Transduction;small hairpin RNA;Stromal Cells;stromal progenitor;Structure;Therapeutic;Therapeutic Intervention;Time;tissue repair;Tissues;Transforming Growth Factor beta;Transplantation;Trauma;Vision;Work;wound;wound care;wound healing;wound response

PROJECT_TITLE: Regulation of tissue repair and scar formation by the stromal niche

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Lowering triglycerides (TGs) for preventing coronary heart disease is a rapidly growing area of research and several drugs that target particular TG genes are in development. However, other than lowering TGs, we don’t know what the long-term beneficial and harmful effects of these drugs will be. We propose to define the pleiotropy of new TG-lowering drugs and to identify new drugs in large electronic health records (EHRs) using genetic approaches.

PI_NAMEs: FENG, QIPING  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 20 year old;Academic Medical Centers;Adverse effects;Affect;African American population;African ancestry;American;ANGPTL3 gene;ANGPTL4 gene;apolipoprotein C-II;Area;biobank;Biological Process;Candidate Disease Gene;candidate identification;Cause of Death;Cessation of life;clinical phenotype;Computerized Medical Record;Coronary heart disease;Data;Data Set;Databases;Development;Diabetes Mellitus;diabetes risk;Disease;disorder prevention;drug candidate;drug development;drug repurposing;Drug Targeting;Electronic Health Record;European ancestry;exome;exome sequencing;Gene Expression;gene function;Genes;Genetic;genetic approach;Genetic Research;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Genotype;Hypertriglyceridemia;Individual;inhibitor;interest;Knowledge;LDL Cholesterol Lipoproteins;Link;lipoprotein lipase;Long-Term Effects;Measures;Mendelian randomization;neglect;new therapeutic target;novel;novel strategies;novel therapeutics;Obesity;Pancreatitis;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiology;Plasma;pleiotropism;post-market;prevent;Proxy;rare variant;Research;Risk Reduction;Sampling;Signal Transduction;Tail;Testing;Time;Tissues;trait;transcriptome;transcriptomics;Triglycerides;Variant;virtual;whole genome

PROJECT_TITLE: Genetics and Triglycerides: opportunities for new approaches to identify therapies

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Leveraging multimodal neuroimaging and neuromodulation, this study aims to unify spatiotemporal alterations in thalamocortical circuitry functioning in both experimental and clinical pain. It will produce novel mechanistic evidence to advance the conceptualization and treatment of pain.

PI_NAMEs: KONG, JIAN  (contact);LI, WEN

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: active control;Acute Pain;Address;Advocate;Anxiety;Attenuated;Back;Brain;Cephalic;Chronic;Chronic low back pain;chronic pain;Clinical;Clinical assessments;clinical pain;Complex;Coupled;design;Development;Dimensions;Double-Blind Method;effective intervention;Electroencephalography;Enrollment;Exhibits;experience;Experimental Models;experimental study;Florida;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;functional restoration;General Hospitals;Goals;Hyperactivity;Impairment;insight;Investigation;Limbic System;Link;Maintenance;Methodology;Modeling;multimodal neuroimaging;neural;neuropsychiatric disorder;neuroregulation;Noise;novel;Pain;Pain management;pain perception;pain symptom;Participant;Pathology;Patients;Periodicity;pressure;Protocols documentation;recruit;Reproducibility;response;Rest;Role;Sampling;Severities;Site;spatiotemporal;Symptoms;Thalamic structure;Therapeutic;Therapeutic Effect;Translating;Treatment Cost;Validation

PROJECT_TITLE: Spatiotemporal Alterations of Thalamocortical Circuitry Functioning Underlie Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Genetics;Natural Products

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Fungal natural products are a prolific source for new drug discovery. The rapid emergence of drug resistance to current pharmaceuticals requires the discovery of new molecules with novel chemical structures. We propose to discover novel fungal NPs and characterize their biosynthetic pathways using advanced CRISPR‐Cas genome‐editing toolkits.

PI_NAMEs: GAO, XUE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Academia;algorithm development;Anabolism;analog;Bioinformatics;bioinformatics tool;Characteristics;Chemical Structure;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Dedications;Development;drug candidate;drug discovery;Drug Industry;Drug resistance;Enzymes;Fungal Genome;Fungal natural products;Fungal Peptides;fungus;Gene Cluster;gene editing technology;Genetic;genetic manipulation;genome editing;Genome engineering;Goals;Human;human disease;interest;Investigation;Medicine;Molds;Natural Products;next generation;novel;novel therapeutics;Pathway interactions;peptide natural products;Peptides;pharmacologic;Pharmacologic Substance;Play;Property;Research;Ribosomes;Role;Source;Technology;Therapeutic;tool

PROJECT_TITLE: Advancing CRISPR-Cas Technologies for the Discovery and Characterization of Novel Fungal Natural Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Chiral molecules have impacted human health in the form of chemical tools to study biological systems and pharmaceutical drugs to treat disease (for example many top selling drugs in the US are chiral and are marketed as enantiopure chemical entities). Although several environmentally friendly photochemical methods exist for the stereoselective synthesis of molecules, many chiral structures still present unique challenges in synthesis. We believe there is great potential for discovering conceptually novel photochemical catalytic reactions for the stereoselective synthesis of medicinally valuable chiral molecules, and the development of these reactions is the focus of this proposal.

PI_NAMEs: TAMBAR, UTTAM KRISHAN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Stereoselective Photochemistry for the Synthesis of Bioactive Molecules

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Neurosciences

PHR: Neurotransmitter receptors form higher-order clusters at synapses to enable signal transmission, and the disfunction of which leads to neurological diseases such as hyperekplexia, chronical neurological pain and reduction in cognitive abilities. Despite their importance, the physical organization, the functional significance, and whether clustering of receptors provides additional mechanism of functional regulation is not known. We will use the state-of-the-art methods and develop novel technologies to characterize receptor assemblies, first using glycine receptor-gephyrin clusters as an example, and open new research area in other assemblies ubiquitously found in signal transmission.

PI_NAMEs: WANG, WEIWEI  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adult;Architecture;Area;autism spectrum disorder;Biology;Cells;Chronic;cognitive ability;Complex;Confusion;Cryoelectron Microscopy;Disease;Electrophysiology (science);experimental study;Family;Fluorescence Microscopy;Functional disorder;gephyrin;Glycine Receptors;Human;Image;Individual;Ion Channel;Ion Channel Gating;Knowledge;Learning;Ligands;Membrane Lipids;Memory;Methods;Nervous System;Nervous System Disorder;Neurologic;neurotransmission;Neurotransmitter Receptor;new technology;Noise;novel;Pain;particle;Physiological;Physiological Processes;Proteins;receptor;Receptor Signaling;reconstitution;Regulation;Research;scaffold;Scaffolding Protein;Signal Transduction;single molecule;stoichiometry;Structure;Synapses;System;Tissues;tomography;transmission process;Work

PROJECT_TITLE: Understanding higher-order glycine receptor assemblies in neurotransmission

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: PROJECT NARRATIVE In order to address problems associated with reduced efficacy of the current BCG vaccine and the spread of tuberculosis (TB), we have generated newer strains of BCG engineered to express molecules that promote robust anti-bacterial responses. Based on our preliminary studies, we hypothesize that our BCG strains promote long-term functional changes in specific immune cells through a newly discovered phenomenon called “trained immunity”. In order to translate these findings into potential clinical benefits, we propose to first examine the efficacy of these strains in models of TB established in non-human primates and mice, and to examine myeloid cells derived from them, and from human peripheral blood treated with these BCG strains, for established markers of trained immunity.

PI_NAMEs: BISHAI, WILLIAM RAMSES (contact);MEHRA, SMRITI

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;Adult;Aerosols;Alveolar;Animal Model;Anti-Infective Agents;Antibacterial Response;Antitumor Response;ATAC-seq;Attenuated;Autophagocytosis;Autopsy;BCG Live;BCG Vaccine;Blood;cancer cell;cancer immunotherapy;Cause of Death;Cavia;Cell Line;Cell Reprogramming;Cells;Cellular Immunity;ChIP-seq;Chromatin;Clinical;Communicable Diseases;Confocal Microscopy;cost effective;cytokine;Dendritic Cells;Development;Disease;disorder prevention;effector T cell;efficacy evaluation;Engineering;Epigenetic Process;epigenetic profiling;Evaluation;Flow Cytometry;Glycolysis;guinea pig model;Histologic;Histones;Human;Immune;Immunity;Immunotherapy;improved;in vitro Model;in vivo Model;Infant;Inflammatory;Inflammatory Response Pathway;Interferons;Intervention;Intravenous;intravesical;IRF3 gene;Licensing;Lymphoid Cell;Macrophage;Malignant neoplasm of urinary bladder;Measures;Medicine;metabolomics;Modeling;monocyte;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Myeloid Cells;Nature;non-muscle invasive bladder cancer;nonhuman primate;nonhuman tissue;novel;overexpression;peripheral blood;Phagocytosis;Phenotype;polarized cell;Population;prevent;protective efficacy;Publishing;Pulmonary Tuberculosis;Rattus;reactivation from latency;Recombinants;Recording of previous events;recruit;response;Route;Safety;Sampling;single-cell RNA sequencing;STING agonists;Testing;Tissues;tool;Training;transcriptional reprogramming;transcriptome sequencing;Translating;Tuberculosis;tuberculosis granuloma;Tuberculosis Vaccines;Vaccinated;Vaccination;Vaccines;Virulent

PROJECT_TITLE: A STINGing vaccine for TB

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE The Network of the National Library of Medicine Evaluation Center (NEC) will provide the Network of the National Library of Medicine (NNLM) with data-driven resources to support evaluation, continuous improvement, and communication of impact of programs and activities. Through this work, data, evaluation and software tools, and methods will be made openly available. These resources will be supported with community and capacity building initiatives to develop and sustain the use of evaluation to support and advance NNLM’s mission.

PI_NAMEs: HOLMES, KRISTI  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Abbreviations;Accountability;Advocacy;authority;Clinical Sciences;Collaborations;Communication;Communication Programs;Communities;community building;Community of Practice;Consultations;Data;Data Collection;data integration;data management;data standards;design;Development;Effectiveness;efficacy evaluation;empowerment;Ensure;Ethics;European;Evaluation;Evaluation Reports;experience;FAIR principles;Fostering;Funding;Health;health disparity;Health Personnel;Health Professional;Health Science Library;implementation evaluation;implementation facilitation;improved;Information Resources;Infrastructure;Investments;Knowledge;knowledge translation;Learning;Medical Libraries;Medicine;member;Methods;Mission;Nuclear;Outcome;outreach;Persons;Process;programs;Public Health;Reporting;Research;Research Personnel;Resources;Services;Software Tools;Standardization;Strategic Planning;Structure;System;tool;Training;Translational Research;Underrepresented Populations;United States National Library of Medicine;Universities;Visualization;web services;Work;Workforce Development


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Kidney Disease;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Wilms tumor 1 (Wt1) mutations result in severe defects in the developing kidney and predispose to Wilms tumor, demonstrating a link between the dysregulation of normal development and tumorigenesis. While reciprocal signaling interactions are known to play critical roles in normal kidney development, such cell-cell communication has been largely unexplored in the development of Wilms tumor. The goal of this application to determine how loss of Wt1 in the nephron progenitor lineage non-autonomously affects the developing stroma to identify mechanisms in which NPC signaling regulates the stroma in normal development and uncover a novel role for Wt1 mutations in disrupting cell lineage crosstalk in the embryonic microenvironment.

PI_NAMEs: DRAKE, KERI ANNE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Affect;Apoptosis;beta catenin;Bioinformatics;blastema;Candidate Disease Gene;candidate identification;career;career development;Cell Communication;Cell Cycle;Cell Differentiation process;Cell Lineage;Cells;clinically significant;Data;Defect;Development;Development Plans;Diphtheria Toxin;Disease;Ectopic Expression;Embryo;Environment;experimental study;Foundations;Future;Gene Expression;Genes;Genetic;Genetic study;Genetically Engineered Mouse;Goals;Histology;In Vitro;in vitro Assay;in vivo;insight;intercellular communication;K-Series Research Career Programs;Kidney;Lentivirus Vector;Ligands;Link;loss of function;Maintenance;Mentors;Mentorship;Metanephric Diverticulum;Modeling;Molecular;mouse model;mutant;mutant mouse model;Mutation;Nephroblastoma;nephrogenesis;Nephrology;nephron progenitor;Nephrons;novel;Pathway interactions;Pattern;Play;Population;Proliferating;receptor;Recombinant Proteins;Regulation;Regulator Genes;research and development;Research Personnel;Rest;Role;self-renewal;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Small Interfering RNA;stem cell differentiation;stem cell population;stem cell proliferation;stem cells;Stromal Cells;stromal progenitor;Structure;Techniques;Testing;Training;tumor;Tumor Biology;tumorigenesis;United States National Institutes of Health;Validation;Vesicle;Wilms Tumor Genes;Work;WT1 gene

PROJECT_TITLE: Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidney


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative A major cause of male infertility is defective and atypical development of the reproductive tract system. Our proposed study will elucidate the cellular and molecular mechanisms underlying androgen-dependent male reproductive tract development, the knowledge of which is essential for the development of better strategies for the prevention, diagnosis, and treatment of disorder of male sexual development.

PI_NAMEs: ZHAO, FEI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Affect;Androgen Receptor;androgen sensitive;Androgens;Apoptosis;ATAC-seq;Chromatin;Connective Tissue;Development;Diagnosis;Disease;Ductal Epithelium;Embryo;Embryonic Structures;Ensure;Epididymis;Epithelium;Event;Female;Fluorescence-Activated Cell Sorting;Future Generations;Gene Expression;Gene Expression Profiling;Genetic;Growth Factor;Human;Impairment;Infertility;Knock-out;knockout gene;Knockout Mice;Knowledge;Lead;Maintenance;male;Male Infertility;Mediating;Mesenchymal;Mesenchyme;Metabolism;Molecular;Morphogenesis;mouse model;Mutation;Organ;paracrine;Pathology;Pattern;Physiology;Prevention strategy;Process;progenitor;programs;Proliferating;receptor expression;Reproduction;reproductive development;reproductive tract;Role;Seminal Vesicles;Sex Differentiation;Sexual Development;Signal Transduction;single cell ATAC-seq;single cell mRNA sequencing;Sorting;sperm cell;Sperm Transport;Structure of mesonephric duct;System;Testing;Testis;Tissues;transcriptome;transcriptome sequencing;transmission process;Variant;WNT Signaling Pathway

PROJECT_TITLE: Mechanisms of androgen-dependent Wolffian duct differentiation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Neurodegenerative disease incidence is increasing as our population ages, yet we lack effective treatments for these diseases. While the social behavior changes that occur across many dementias, particularly frontotemporal dementia (FTD), account for a tremendous portion of disease burden, these behavioral sequelae have been understudied as a mechanistic entity or therapeutic target. The proposed project will develop a novel animal model to examine the genetic, molecular, and neural circuit factors that underlie social attachment deficits in FTD and other neurodegenerative diseases.

PI_NAMEs: BERENDZEN, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Affect;Age;age related;age related changes;age-related disease;aged;Aging;Animal Model;Behavior;behavior change;Behavior Therapy;Behavioral;Bioinformatics;Biological Models;Biology of Aging;Brain;brain health;Brain region;burden of illness;California;career;career development;cell type;Cells;Characteristics;Clinical;comparative genomics;Dementia;dementia risk;design;Diagnostic;Disease;disease model;Doctor of Philosophy;effective therapy;Empathy;Endocrine;Exhibits;experience;Fiber;Foundations;Frontotemporal Dementia;Funding;gene conservation;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic;genetic signature;Goals;Image;Immunohistochemistry;Impairment;in vivo calcium imaging;Incidence;innovation;interest;Intervention;K-Series Research Career Programs;Knock-out;late life;Lead;learning strategy;Link;Maintenance;Maps;Mediating;Mediator;Mentors;Mentorship;Methods;Microtus;model organism;Molecular;Molecular Analysis;Molecular Genetics;Molecular Profiling;Monitor;Motivation;mutant;neural;neural circuit;neural patterning;Neurobiology;Neurodegenerative Disorders;neuromechanism;Neurons;neuropathology;neurophysiology;neuropsychiatric disorder;neuropsychiatry;Neurosciences;Neurosecretory Systems;new therapeutic target;novel;novel strategies;Nucleus Accumbens;Oxytocin;Oxytocin Receptor;Pair Bond;Pathology;Pathway interactions;Patient-Focused Outcomes;Pattern;PGRN gene;Photometry;Physicians;Physiology;Population;Positioning Attribute;prairie vole;Program Development;programs;Psychiatrist;Receptor Signaling;Research;Research Methodology;Research Personnel;risk variant;Rodent;Role;San Francisco;Scientist;Signal Transduction;single nucleus RNA-sequencing;skills;social;social attachment;Social Behavior;social cognition;social deficits;Social isolation;social vulnerability;Symptoms;System;Testing;therapeutic target;Tissues;tool;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;Universities;Viral;Work

PROJECT_TITLE: Neural mechanisms of social attachment disruption in frontotemporal dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Mental Health;Neurosciences;Patient Safety;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Brain Computer Interfaces (BCIs) are innovative and cutting-edge technologies that measure and interpret brain signals to interface with a device that allows users to perform a task, and while BCIs hold great promise in their transformative potential for patients with neurologic disability, there are critical unaddressed ethical challenges that have the potential to limit their adaptation. This project will use innovative approaches including structured vignettes, video-supported interviews, and deliberative democracy to qualitatively evaluate end user perspectives about the benefits, risks, and ethical challenges of BCIs. Our transdisciplinary research team and the diverse input from patients with neurologic disability and their family/caregivers, clinicians who care for patients with acute neurologic injury, and BCI researchers and engineers will inform future decisions and policies about ethical and equitable adaptation of BRAIN-funded BCI technology.

PI_NAMEs: HIRSCH, KAREN G (contact);TABOR, HOLLY K

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Acute;Acute Brain Injuries;acute care;Address;Affect;Area;Attitude;Benefits and Risks;Brain;brain computer interface;Brain Diseases;BRAIN initiative;Brain Injuries;Caregivers;Chronic Care;clinical decision-making;clinical practice;Collaborations;Communication;Communication Disability;Critical Care;Data;Decision Making;deliberative democracy;design;Development;Devices;Disabilities experience;disability;disability impact;Disability outcome;disabled;Engineering;Ensure;Equity;Ethical Issues;Ethicists;Ethics;Family;Family Caregiver;Family member;Funding;Funding Opportunities;Future;Healthcare;Hemorrhage;Human;innovation;Intervention;Interview;Ischemia;Justice;Measures;Methodology;Motor;Movement;Nervous System Trauma;neural;Neurologic Deficit;Neurological disability;Neurologist;neuroregulation;Neurosciences Research;Neurosurgeon;neurotechnology;novel;Outcome;Participant;Pathway interactions;Patient Care;Patients;Perception;Personhood;physically handicapped;Physicians;Policies;post stroke;Privacy;Prognosis;Quality of life;Recommendation;recruit;Research;Research Personnel;Risk;Safety;Science;Series;Signal Transduction;social stigma;stakeholder perspectives;Stroke;Structure;Subacute Care;Technology;tool;Translations;Traumatic Brain Injury;usability;Work

PROJECT_TITLE: BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Hi-C is a popular technology to map how DNA folds and affects gene expression and diseases in the nucleus. However, high resolution Hi-C analysis requires ultra-deep sequencing, which is a major financial burden and often not feasible for low-input or single cell samples. This project will use deep- learning techniques to reduce such burden by more than 10-fold, and also enables high-resolution analysis with single cell Hi-C data.

PI_NAMEs: JIN, FULAI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: 3-Dimensional;Address;Affect;Benchmarking;Brain;Cell Nucleus;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;Chromosome Mapping;Communities;Complex;computerized tools;Copy Number Polymorphism;cost;Data;Data Analyses;data resource;Data Set;deep learning;deep sequencing;Digestion;Disease;DNA Folding;DNA mapping;Error Sources;Financial Hardship;Future;Gene Expression;Genes;Genets;Genome;genome analysis;Genome Mappings;genome-wide;Goals;Grant;Hi-C;Hiccup;Homologous Gene;Human;Ice;improved;innovation;Islets of Langerhans;Libraries;mammalian genome;Maps;method development;Methods;Names;Noise;Paper;Performance;performance tests;Phase;Population;promoter;Protocols documentation;Publishing;Reporting;Research;Resolution;Resources;Sampling;Scientist;Signal Transduction;Structure;success;Systematic Bias;Techniques;Technology;Tissues;tool;Variant;Work

PROJECT_TITLE: Robust mapping of chromatin loops from sparse or single cell Hi-C data with DeepLoop

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Congenital Human diseases are frequently associated with aberrant function of genes used in early development. Here we will understand the regulation and function of gene products that act in the normal patterning of the early embryo, including the regulators of cell shape change.

PI_NAMEs: HARLAND, RICHARD M (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Amphibia;Anterior;Biochemical;cell behavior;Cell Shape;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;confocal imaging;Defect;Development;egg;Embryo;Embryonic Development;Evolution;experimental study;Family;gastrulation;Gene Expression;gene function;gene product;Genes;Genetic Recombination;Genome;Goals;Grant;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;human disease;Image;improved;insight;knock-down;Mediating;member;Microinjections;Microsurgery;Molecular;Morphogenesis;Movement;neural;neural patterning;neural plate;Pattern;Proteomics;Rana;Regulation;Research;Resources;rho;Signal Transduction;Structure;System;Tissues;Xenopus

PROJECT_TITLE: Gene Expression in Amphibian Development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The KCNH2 gene encodes the Kv11.1 membrane protein that transports potassium ions out of cardiac muscle cells to maintain normal heart rhythm and dysfunction of the Kv11.1 protein causes long QT syndrome, a cardiac disorder characterized by severe arrhythmias and sudden cardiac death. The goal of present proposal is to study post-transcriptional regulation of Kv11.1 protein expression and to investigate a novel mechanism of drug-induced long QT syndrome. Elucidating these mechanisms is important for understanding of Kv11.1 protein expression in normal and disease conditions.

PI_NAMEs: ZHOU, ZHENGFENG  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 5' Splice Site;Action Potentials;Adult;Alternative Splicing;Antineoplastic Agents;Arrhythmia;Cardiac;Cardiac Myocytes;cardiogenesis;cis acting element;Clinical Trials;Development;Disease;drug development;Enhancers;Ethers;Exons;Genes;Goals;Heart;Heart Diseases;heart rhythm;Human;Inherited;inhibitor;Introns;Knock-in Mouse;Length;Long QT Syndrome;Membrane Transport Proteins;Messenger RNA;Molecular;mouse model;mRNA Precursor;Mus;mutant;Mutation;Myocardial dysfunction;novel;Pathogenicity;Pharmaceutical Preparations;Play;Polyadenylation;Post-Transcriptional Regulation;posttranscriptional;Potassium Channel;potassium ion;Process;protein expression;Protein Isoforms;Proteins;Regulation;RNA;RNA Splicing;RNA-Binding Proteins;Role;Signal Transduction;Site;sudden cardiac death;Testing;Trans-Activators;Type 2 Long QT syndrome

PROJECT_TITLE: Post-transcriptional regulation of Kv11.1 (hERG) channel expression by alternative splicing and polyadenylation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Dilation & curettage (D&C) is one of the most common surgical procedures performed on women throughout the World, with resulting intrauterine fibrosis developing in ~40% of women who undergo D&C in the postpartum (6wk period after birth), but is very rare after D&C in nonpregnant women (<1%). While stem/progenitor cells are crucial for endometrial repair, the role of these cells and underlying molecular mechanisms in this susceptibility of the endometrium to fibrosis and abnormal repair are unknown. This work will have an important impact on the reproductive field by revealing mechanisms underlying abnormal uterine repair, and on the medical field at large by providing insights into the body’s physiological anti-fibrotic wound healing mechanisms, leading to a deeper understanding of the pathogenesis of fatal idiopathic fibrotic diseases in other organs.

PI_NAMEs: TAL, RESHEF  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Ablation;Adhesions;Adult;Affect;Archives;Asherman Syndrome;Bar Codes;Biology;Birth;Cell Aging;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cicatrix;Cre-LoxP;Dangerousness;Data;Development;Dilatation and Curettage;Disease;Endometrial;Endometrium;Event;exhaustion;Fertility;Fibroblasts;Fibrosis;Functional disorder;Gene Expression Profile;Genetic;Goals;Habitual Abortion;Heart;Human;iatrogenic injury;idiopathic pulmonary fibrosis;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vitro Assay;Infertility;Injury;innovation;insight;Knowledge;Liver;Lung;Mechanics;Medical;Menstrual cycle;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;multiple omics;Mus;National Institute of Child Health and Human Development;Natural regeneration;new therapeutic target;novel;Operative Surgical Procedures;Organ;Pathogenesis;Pathway interactions;Patients;Physiological;Play;Population;Postpartum Period;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;Premature Birth;prevent;Prevention;profibrotic fibroblast;Property;Proteins;Recurrence;repaired;Reporter;reproductive;Research Priority;response;response to injury;Role;senescence;sequencing platform;single cell technology;single-cell RNA sequencing;Specimen;stem cells;stemness;System;Time;tissue mapping;Tissues;transcriptome;Trauma;Uterus;Woman;Work;wound healing

PROJECT_TITLE: THE ROLE OF MESENCHYMAL PROGENITOR CELLS IN ABNORMAL UTERINE REPAIR

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: The need for investigators who are well trained in both basic science and clinical research has been and continues to be an unmet need. NIGMS Medical Scientist Training Programs (MSTP) were developed to meet the need for more physician scientists and offer unique training opportunities. The UCCOM MSTP meets these goals and prepares graduates for diverse careers as physician scientists.

PI_NAMEs: KHURANA HERSHEY, GURJIT K. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE East Africa is one of the fastest growing regions of the world, with an increasing burden of non-communicable diseases, including cancer. Cancer research in the region is nascent; however, the rising disease burden urgently demands development of research skills and capacity to establish context-specific cancer control plans. The overarching goal of our proposed Cancer Research Training Program in Tanzania (CRTP-TZ) is to train and mentor a cadre of investigators in East Africa who are capable of conceptualizing, achieving funding for, implementing, analyzing, and publishing original research focused on cancer.

PI_NAMEs: MMBAGA, ELIA JOHN;VAN LOON, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Advanced Development;Africa;African;Ally;anti-cancer research;Attention;Cancer Burden;Cancer Control;career;career development;Collaborations;Communicable Diseases;Competence;Country;Death Rate;Development;Discipline;Education;Environment;evidence base;Face;Faculty;flexibility;Fostering;Funding;Future;Goals;Growth;Health;improved;Incidence;Individual;Infrastructure;Learning;Malignant Neoplasms;Mentors;Mentorship;Modeling;Morbidity - disease rate;Oceans;Outcome;Pathway interactions;Play;Policies;population health;Positioning Attribute;Principal Investigator;Productivity;Publishing;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Tanzania;theories;Training;training opportunity;Training Programs;Universities

PROJECT_TITLE: Building a Cancer Research Training Program in Tanzania


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cardiovascular;Genetics;Heart Disease;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative. Alcoholic cardiomyopathy (AC) can result from chronic alcohol use; this process progressively damages the heart and decreases the heart’s function. In this study, we aim to define part of the molecular phenomenon occurring in AC using genetically altered mice, cells, and a novel drug that inhibits the action of key components in the underlying molecular process. This study may open new therapeutic options for those suffering from AC.

PI_NAMEs: EDAVETTAL, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol response;alcohol use disorder;Alcoholic Cardiomyopathy;Alcohols;Area;Attenuated;Binding;Biological Markers;Blood alcohol level measurement;Cardiac;Cardiac Catheterization Procedures;cardiogenesis;Cardiology;Cardiovascular Diseases;Cells;Chronic;chronic alcohol ingestion;Clinical;Collagen;coronary fibrosis;Data;Development;Disease;Dose;Echocardiography;End Point Assay;Ethanol;experimental study;Exposure to;Family member;Fibroblasts;Fibrosis;Functional disorder;Gene Modified;genetic manipulation;Health;Heart;heart damage;heart function;Heart Hypertrophy;Hour;Hydroxyproline;IL6 gene;Immunohistochemistry;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Inflammatory Response;interest;Intervention;Left;Length;Lentivirus Vector;Link;LOX gene;Measures;Mediator;Mentors;Messenger RNA;Modeling;Molecular;mouse model;Mus;Mutate;Myocardial dysfunction;Myocarditis;National Institute on Alcohol Abuse and Alcoholism;NF-kappa B;novel;novel therapeutics;Phosphorylation;Physicians;Physiological;Physiology;Prevalence;prevent;Process;Proteins;Rattus;receptor;Research;Research Personnel;response;Ribonucleoproteins;Role;Scientist;Series;short hairpin RNA delivery;Side;small hairpin RNA;small molecule inhibitor;Stains;Stress;Structure;Testing;therapeutic target;Training;Transforming Growth Factor beta;Translations;United States;United States National Institutes of Health;Universities;Ventricular;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Larp6 and Alcoholic Cardiomyopathy


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Social Determinants of Health;Telehealth

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Summary The research goal of this application is to use health IT to reduce preventable readmissions for heart failure (HF) among patients with low health literacy, through a text-based messaging application. We will conduct qualitative work to gain insights into how to adapt an extant text messaging intervention to improve its use among patients with low health literacy, conduct usability testing and iterative revision of the application, and conduct a pilot randomized controlled trial (RCT) to evaluate the acceptability, feasibility, and preliminary efficacy of using behavioral interventions to increase the application use for patients with heart failure post- discharge. The training from this mentored career development award will provide skills in behavioral science, implementation science, health literacy, and RCT design and conduct, to provide the foundation for my career as an independent clinician investigator.

PI_NAMEs: KIM, EUN JI  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Applications Grants;automated text message;Behavior Therapy;Behavioral Sciences;Cardiovascular system;career;Caring;Cellular Phone;Clinical;Clinical Investigator;Computers;Effectiveness;experience;Failure;Feedback;Focus Groups;Foundations;Goals;group intervention;Health;health care service utilization;health information technology;health literacy;Health system;Heart failure;Homelessness;hospital readmission;Hospitalization;Hospitals;implementation science;improved;Individual;insight;Intervention;K-Series Research Career Programs;Knowledge;low health literacy;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Monitor;Nurses;Outcome;Patient Care;patient handout;patient navigator;Patient Triage;Patients;Perception;Physicians;poor health outcome;Positioning Attribute;posthospitalization care;power analysis;prototype;Randomized;Randomized, Controlled Trials;Research;Research Activity;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Risk;Sample Size;screening program;Services;skills;social;social health determinants;Technology;Testing;Text;Text Messaging;text messaging intervention;theories;Time;tool;Training;Training Activity;Transcript;trial design;uptake;usability;Use Effectiveness;usual care arm;Work

PROJECT_TITLE: Leveraging Heath Information Technology to Improve Post-Discharge Management for Patients with Heart Failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Colorectal Cancer;Contraception/Reproduction;Digestive Diseases;Genetics;Hematology;Human Genome;Infertility;Pediatric;Pediatric Cancer;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Male infertility is a devastating problem that impacts 7% of all men and has been shown to significantly impact somatic health, particularly risk for both individual and familial cancer. Despite this association, the mechanism driving it remains unknown. We seek to perform a study examining complex pedigree data to assess how infertility can impact familial cancer risk among high risk pedigrees and then use high depth and coverage DNA sequencing to determine if elevated de novo mutation rates in both the germline and somatic tissue are what drive the association between male infertility and poor somatic health.

PI_NAMEs: ASTON, KENNETH IVAN;HOTALING, JAMES  (contact);QUINLAN, AARON R

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Age;Andrology;assisted reproduction;Automobile Driving;Autopsy;Blood;Cadaver;cancer risk;Cardiovascular Diseases;Cause of Death;Childhood Leukemia;Clinic;cohort;Colon;Colon Carcinoma;Complex;congenital anomaly;Consensus;Data;Data Set;de novo mutation;deep sequencing;disorder risk;DNA;DNA sequencing;Electronic Health Record;Environment;epidemiologic data;Epidemiology;Etiology;Family;Family member;Fertility;Follow-Up Studies;Generations;Genetic;genetic pedigree;genome sequencing;Genomic approach;Genomic Instability;Genomics;Germ Cells;Germ Lines;Germ-Line Mutation;Goals;Health;Hereditary Malignant Neoplasm;Heritability;high risk;high risk men;Human;human tissue;Incidence;Individual;Infertility;leukemia/lymphoma;life span;Life Style;Link;Longevity;Male Infertility;Malignant Childhood Neoplasm;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant neoplasm of thyroid;Maps;Measures;men;Mosaicism;Mutation;offspring;Organ;Organ Donor;Paternal Age;Population;Population Database;Prostate;prostate cancer risk;Reproduction;reproductive;Research;Risk;Sampling;Somatic Cell;Somatic Mutation;Sperm Banks;sperm cell;Sperm Count Procedure;stem cells;Subfertile Men;subfertility;Testing;Testis;Tissue Banks;Tissue Donors;Tissues;Utah;Work

PROJECT_TITLE: GEMS: Genomic approach to connecting Elevated germline Mutation rates with male infertility and Somatic health


PHR: PROJECT NARRATIVE Pacemaker cells are responsible for faithfully initiating every heartbeat, yet the mechanisms responsible for their formation and maintenance are not well-understood. Direct reprogramming of fibroblasts into functional cardiomyocytes, including pacemaker cells, has recently emerged as a viable approach for studying lineage specification, but many details of the process remain poorly characterized. Using an innovative and multi- disciplinary approach, we propose to examine pacemaker reprogramming mechanisms to better understand pacemaker formation and to eventually develop cellular replacement strategies for patients with sinus node dysfunction.

PI_NAMEs: MUNSHI, NIKHIL VILAS (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;Biology;Bradycardia;Cardiac;Cardiac conduction system;Cardiac Myocytes;Cardiac pacemaker;Cell Lineage;Cells;Characteristics;Co-Immunoprecipitations;combinatorial;competence factor;Confocal Microscopy;Data;Development;Developmental Gene;Devices;Engineering;Ensure;Fibroblasts;Functional disorder;Future;Gene Expression;gene regulatory network;Genes;Genomic approach;Genomics;Goals;Heart Atrium;Human;immunocytochemistry;implantation;improved;innovation;insight;interdisciplinary approach;Interdisciplinary Study;Knowledge;life span;Literature;Maintenance;Maps;Molecular;Muscle Cells;N-terminal;nodal myocyte;novel;novel strategies;novel therapeutic intervention;Pacemakers;Pathway interactions;Patients;prevent;Process;programs;protein complex;Regulatory Element;Reporting;Repression;Research;Resolution;Shock;Sick Sinus Syndrome;single-cell RNA sequencing;Sinoatrial Node;Specific qualifier value;System;Testing;Therapeutic;Transcription Factor AP-1;Ventricular

PROJECT_TITLE: Exploring Mechanisms of Cardiac Pacemaker Cell Fate Determination

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]