NIH_SPENDING_CATS: Aging;Arthritis;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Chronic Pain;Disability Research;Neurosciences;Osteoarthritis;Pain Research;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Chronic pain is a debilitating symptom of mid to late-stage osteoarthritis causing patients to avoid activities of daily living due to pain during loading. Osteoarthritis is a complex disease involving cartilage, immune cells, and neural cells, however no study to date has tried to tease apart the relationship between mechanical loading and immune activation in osteoarthritis pain. This project will be a step forward in understanding how mechanical signals interact with immune cells to induce mechanically activated pain thus providing a potential new avenue for therapeutic intervention.

PI_NAMEs: ADAMCZYK, NATALIE  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Ablation;Activities of Daily Living;Afferent Neurons;Animal Behavior;Animal Model;Arthralgia;Arthritis;Attenuated;attenuation;Behavior;Biological Assay;Blood;Bradykinin;career;Cartilage;Cells;Chronic;Chronic disability;chronic pain;Combined Modality Therapy;Communication;Complex;Critical Thinking;cytokine;Data;debilitating symptom;Degenerative polyarthritis;Development;disability;Disease;effective therapy;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Exhibits;Experimental Designs;Flow Cytometry;Genetic;Goals;Grant;High Prevalence;Histology;Human;Hyperalgesia;Image;Immune;immune activation;In Vitro;in vivo calcium imaging;Induction of Apoptosis;Inflammation;Inflammation Mediators;Inflammatory;Injections;Ion Channel;joint inflammation;joint injury;joint loading;Joints;Knee;Knee joint;Knock-out;Knowledge;Learning;Leg;Link;Macrophage;Measurement;mechanical load;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Medial;Medial meniscus structure;Mediating;Mediator;Modeling;Molecular;mouse model;Movement;Mus;Nature;Nerve;Nerve Growth Factors;Neuroimmune;neuroinflammation;Neurologic;Neuronal Plasticity;Neurons;Neurosciences;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel;Operative Surgical Procedures;osteoarthritis pain;Outcome;Pain;pain behavior;Pain management;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Persistent pain;Phenocopy;Piezo 2 ion channel;Play;prevent;Prevention;Process;Production;Quality of life;recruit;Reporting;Research;Role;Route;skills;Spinal cord posterior horn;Spinal Ganglia;Swelling;Synovial Fluid;Synovial Membrane;Synovitis;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;Weight;Weight-Bearing state

PROJECT_TITLE: Piezo2-mediated neuroplasticity in osteoarthritis


ADMINISTERING_IC: TW

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: SUMMARY NARRATIVE Low- and middle-income countries experience a high burden of gender-based violence (GBV) and violence against children (VAC); yet, institutional and investigator research capacity is limited, and large data gaps limit the ability to monitor violence-related Sustainable Development Goals. To address this need, Emory University, Hanoi Medical University, and a multidisciplinary network of experts will create CONVERGE, The Consortium for Violence Prevention Research, Implementation, and Training for Excellence. We will implement a four- component program to train a critical mass of long-term post-doctoral fellows (n=15), short-term mid-career research trainees (n=40), and short-term practitioner trainees (n=60), creating a pipeline of professionals skilled in research mentorship, research in GBV and VAC, implementation science, leadership/science dissemination for sustained capacity in GBV and VAC research and practice in Vietnam.

PI_NAMEs: HOANG, THI HAI VAN ;LE, GIANG M;YOUNT, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Adolescent and Young Adult;Alcohol abuse;Alcoholism;Attention;attributable mortality;career development;Child;Child Health;Child Sexual Abuse;Data;disability;Drug abuse;Effectiveness;Evaluation;Exposure to;Future;Gender;gender variant;gender-based violence;girls;Goals;Human Development;implementation evaluation;implementation science;institutional capacity;intimate partner violence;Lead;Leadership;low and middle-income countries;Medical;Medicine;member;Mental Health;Mentors;Mentorship;minority health;minority health disparity;peer victimization;Postdoctoral Fellow;Prevention Research;Productivity;programs;rate of change;Research;Research Personnel;Research Priority;Research Support;Research Training;Science;skills;success;Sustainable Development;Testing;Training;Training Programs;United States National Institutes of Health;Universities;Vietnam;Violence;violence against women;violence prevention;Woman;Women's Health


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Prevention;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Some types of cancers, as exemplified by estrogen receptor positive breast cancer, can recur as metastatic disease many years or even decades following a dormancy period where the patient displays no clinical symptoms. This proposal seeks to engineer T cells as ultrasensitive biosensors to detect dormant cancer and when they reawaken.

PI_NAMEs: KWONG, GABRIEL A (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: angiogenesis;Antibodies;Antigens;Binding;Biological Markers;Biosensor;Blood;Bone Marrow;Breast Cancer Patient;Cancer Detection;cancer immunotherapy;cancer type;Cells;Clinical;design;Detection;Disease;engineered T cells;Engineering;Estrogen receptor positive;extracellular;Future;Genetic;Growth;hormone therapy;Image;In complete remission;in vivo;Libraries;Life;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Memory;Meta-Analysis;Methods;Micrometastasis;Monitor;neoplastic cell;No Evidence of Disease;Patients;Peptide Hydrolases;Peptides;Phenotype;Proteolysis;receptor;Recurrence;Relapse;Relative Risks;Reporting;Risk;screening;Sensitivity and Specificity;sensor;Site;Sleeping Beauty;Symptoms;T cell therapy;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic Intervention;treatment response;tumor;Tumor Antigens;Urine

PROJECT_TITLE: Finding Sleeping Beauty: T Cell Biosensors for Dormant Cancer Detection


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Inflammatory bowel disease is a chronic illness that represents a significant public health and economic burden, and there is an urgent need to improve our understanding of modulators of intestinal inflammation in order to identify novel therapeutic targets. Recent studies from our lab have demonstrated that specialized immune cells known as group 2 innate lymphoid cells (ILC2s) respond to neuronal-derived signals to promote expulsion of intestinal parasites, but whether or not these same signals activate the tissue protective functions of these cells is unclear. The focus of this proposal is to dissect the role of this neuro-immune signaling pathway in the regulation of intestinal inflammation.

PI_NAMEs: ARTIS, DAVID  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Allergic;Allergic inflammation;American;Amphiregulin;associated symptom;Attenuated;attenuation;Biological Products;Biology;Biopsy;Bone Marrow Suppression;Cell Communication;Cell Lineage;Cell Physiology;Cells;Chemical Models;Chemicals;Chronic;Chronic Disease;Clinical;Colon;cost;Crohn's disease;cytokine;Cytometry;Data;Development;Diarrhea;Disease;Economic Burden;Economics;Enteral;Environmental Risk Factor;Epidermal Growth Factor Receptor;Family;Flow Cytometry;gastrointestinal;Genetic;Genetic Transcription;gut inflammation;Healthcare Systems;Helminths;Hemorrhage;Homeostasis;Human;Image;Immune;Immunity;improved;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;injury and repair;insight;Integration Host Factors;intestinal injury;Intestinal parasite;Intestines;Kinetics;Ligands;liver inflammation;Lymphoid Cell;Malignant Neoplasms;Measures;Mediating;microbial;microbiota;Microscopy;Molecular;mouse model;Mucous Membrane;Mus;Muscle Cramp;Nervous System;Neuroimmune;Neuromedin U;neuromedin U receptor;Neurons;Neuropeptides;new therapeutic target;novel;novel therapeutics;Opportunistic Infections;Pain;Pancreatitis;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Physiological;Population;pre-clinical;Production;Proliferating;Property;Public Health;Pulmonary Inflammation;Quality of life;Regulation;repaired;Reporter;response;Risk;Role;Signal Pathway;Signal Transduction;Sodium Dextran Sulfate;Source;Spatial Distribution;Stimulus;Surface;Testing;Therapeutic;tissue repair;Tissues;Treatment Cost;TSLP gene;Ulcerative Colitis;United States;Up-Regulation

PROJECT_TITLE: Neuro-immune regulation of intestinal inflammation

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: We propose to develop a comprehensive set of statistical methods for analyzing data collected from spatially resolved transcriptomics studies to advance biological discoveries. These statistical methods will help us better understand the spatial transcriptomic landscape and cell type composition of complex tissues as well as the functional and structural foundations of tissue architecture, thus facilitating the investigation of disease etiology and the development of precision medicine.

PI_NAMEs: ZHOU, XIANG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;African American Women;Architecture;Area;Awareness;Biological;Biology;cancer health disparity;cell type;Cells;Communities;Complex;Computer software;Computing Methodologies;Data;Detection;detection method;Development;Disease;Etiology;experimental study;Face;Foundations;Genes;Heterogeneity;histological image;Investigation;Location;Malignant Breast Neoplasm;Measures;Methods;Modeling;Modems;National Institute of General Medical Sciences;novel;open source;Pathway interactions;Pattern;Performance;precision medicine;Process;Resolution;Role;simulation;single-cell RNA sequencing;software development;Software Tools;Statistical Methods;stem cell biology;Structure;Technology;Tissues;trait;transcriptome;transcriptomics;user-friendly;Validation

PROJECT_TITLE: DMS/NIGMS 2: Advanced Statistical Methods for Spatially Resolved Transcriptomics Studies


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT STATE DEPT OF PUBLIC HEALTH

ORG_STATE: CT

PHR: The State of Connecticut Department of Public Health PAR-20-124 NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens(U01) Clinical Trials Not Allowed Project Narrative The purpose of the National Antimicrobial Resistance Monitoring System (NARMS) Retail Meat Surveillance Program is to protect and promote public health by strengthening and sustaining antibiotic resistance surveillance in retail food samples. The goal of this surveillance project is to determine the prevalence of antibiotic resistance among Salmonella, Campylobacter, Escherichia coli, Enterococcus, Vibrio, Aeromonas, and other lactose positive bacteria isolated from retail food samples purchased from grocery stores in the United States. Data from this project will contribute to improving the detection and surveillance of resistance among foodborne bacteria, promote interventions to reduce drug resistance by determining limitations for antibiotic use in veterinary medicine, and by assisting in the development of pre-approval safety evaluation for new animal antibiotics.

PI_NAMEs: RAZEQ, JAFAR  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: The State of Connecticut Department of Public Health Retail Food Program


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative Parasitic nematodes remain a significant public health problem in many parts of the world, with Ascaris alone infects upwards of 1 billion people and hinders socioeconomic development in endemic areas. We will carry out molecular and genomic studies on an unusual form of genome re-organization and mechanism of gene regulation in Ascaris, programmed DNA elimination. These studies have the potential to identify novel molecular mechanisms that may represent novel drug targets in these organisms.

PI_NAMEs: WANG, JIANBIN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3-Dimensional;Architecture;Area;Ascaris;Biological;Biological Process;Cell Cycle;Cell Lineage;Centromere;Cessation of life;Child;Chromatin;Chromosomal Breaks;chromosomal location;Chromosome Breakage;Chromosome Structures;Chromosomes;Complex;Deposition;Development;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Replication Timing;Drug Targeting;ds-DNA;Epigenetic Process;Event;Evolution;Excision;Exhibits;Family suidae;flexibility;Future Generations;Gene Expression Regulation;Gene Silencing;Generations;Genes;genetic information;Genetic Transcription;Genome;genome integrity;genome-wide;Genomic Segment;Genomics;Germ Lines;healing;Health;Human;improved;insight;Invertebrates;Kinetochores;life span;Location;Maintenance;Manuscripts;Maps;Mitosis;Molecular;Molecular Biology;Morbidity - disease rate;new therapeutic target;novel;Nuclear;Nucleotides;Organism;Parasitic nematode;Persons;Physiological Processes;Positioning Attribute;Preparation;Process;Public Health;recruit;repaired;replication stress;Research;Resected;RNA;segregation;Site;socioeconomic development;Somatic Cell;Specific qualifier value;Stress;System;telomere;Testis;tool;Toxocara;Toxocariasis;United States;Variant;Vertebrates;Work

PROJECT_TITLE: Programmed DNA Elimination in Parasitic Nematodes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Histones are highly-conserved proteins that regulate gene expression and are mutated in cancers. We recently identified a testis-specific histone variant, H2A.B, that is aberrantly upregulated in a broad array of common cancers and mimics cancer-associated mutant histones. This proposal is designed to identify the mechanism by which H2A.B contributes to cancer.

PI_NAMEs: SARTHY, JAY  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Alternative Splicing;Amino Acid Sequence;Anthracycline;Binding;Binding Sites;Bioinformatics;Biology;cancer cell;Cancer Cell Growth;Cancer cell line;cancer genomics;Cancer Model;Carcinoma;Cardiotoxicity;Cell Culture Techniques;Cell Line;Cell Proliferation;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Data;Dependence;design;DNA-Protein Interaction;Doxorubicin;Enhancers;Environment;epigenome;Euchromatin;experimental study;Gene Expression;Genes;Genome;genomic data;Genomics;Heterochromatin;Histone Fold;Histone H2A;histone modification;Histones;Impairment;in silico;In Vitro;Investigation;knock-down;Laboratory Finding;large cell Diffuse non-Hodgkin's lymphoma;Learning;Literature;Lymphoma cell;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Target;Mus;mutant;Mutate;Mutation;Nature;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;Nucleosomes;Oncogenic;oncohistone;Pattern;Phenotype;Poisoning;Positioning Attribute;Prevalence;promoter;Property;Proteins;Recurrence;Regimen;Regulation;Reporting;response;RNA analysis;Role;side effect;small hairpin RNA;small molecule;Specimen;sperm cell;Spliced Genes;Technology;Testing;Testis;The Cancer Genome Atlas;Therapeutic;Topoisomerase II;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;translational model;trial comparing;tumorigenesis;Up-Regulation;Uterus;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Characterization of short H2A Oncohistones in Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This grant examines how liver cells damaged due to excess fat release small particles called extracellular vesicles which contain a danger signal called S100A11 to activate white blood cells termed macrophages, via a receptor called RAGE. These macrophages, in turn cause liver damage. This research is important because increasing obesity has resulted in large numbers of people with fatty liver disease, for which there are no proven treatments, and with these studies we aim to identify new potential treatments.

PI_NAMEs: MALHI, HARMEET  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetylation;activation product;Address;Applications Grants;Attenuated;Binding;Binding Proteins;biological adaptation to stress;career;Cell Communication;cell injury;Cell Line;Cells;chronic liver disease;Communication;Complex;Data;Diet;Disease;Disease Progression;druggable target;Economic Burden;endoplasmic reticulum stress;Endoribonucleases;Enhancers;Enzymes;EP300 gene;Epigenetic Process;experimental study;extracellular vesicles;Factor X;Fatty acid glycerol esters;fatty liver disease;Gene Modified;Generations;genetic approach;Genetic Transcription;Goals;Grant;granulocyte;Hepatocyte;Histone Acetylation;histone acetyltransferase;Histones;Immune;In Vitro;in vitro Model;in vivo Model;Inflammation;Inflammatory;inhibitor;Inositol;insight;Interruption;intrahepatic;Knock-out;Kupffer Cells;Leukocytes;Link;Lipids;Liver;liver inflammation;liver injury;Lysine;Macrophage;Mediating;Mediator;Molecular;monocyte;mortality;Mouse Strains;Mus;nonalcoholic steatohepatitis;novel;Obesity;particle;Pathogenesis;Pattern;Persons;pharmacologic;Play;Process;Proteomics;receptor;receptor expression;receptor for advanced glycation endproducts;recruit;Research;Role;S100A11 gene;Signal Transduction;Sorting;Stress;Testing;therapeutic target;transcription factor;Transplantation;United States;Up-Regulation;vesicular release

PROJECT_TITLE: Pathobiology of Liver Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(04)]


ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPT/ HEALTH & SENIOR SRV

ORG_STATE: MO

PHR: Project Narrative The Missouri Department of Health and Senior Services (DHSS), Missouri State Public Health Laboratory (MSPHL) proposes to support the National Antimicrobial Resistance Monitoring System (NARMS) Retail Meat Surveillance Program by continuing its current sampling of retail meats and testing for Salmonella and Campylobacter, Enterococcus, Aeromonas, Vibrio and other lactose positive bacteria.,. This project will enhance the collection of data on the occurrence of antibiotic resistant bacteria in the nation’s retail meat supply, and further the aims of NARMS through data sharing with state and federal epidemiologists. In addition, the sharing and review of testing and antimicrobial data will be used by epidemiology programs to detect food borne disease outbreaks and coordinate investigations; educate state and local public health officials and the general public on current and emerging health hazards; support food safety program awareness of antimicrobial resistance among the public; analyze for trends to inform state health agency management and assist with policy development; and data will be used by the laboratory to assess accuracy of testing results and quality assurance practices. Page 1 of 1

PI_NAMEs: LUEBBERING, LEON  (contact)

PROJECT_TITLE: FDA NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimans


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Hematology;Infertility;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Women with sickle cell anemia (SCA) lack fundamental information about their reproductive lifespan and whether SCA or its therapies reduce ovarian reserve. This research measures ovarian reserve in women with SCA and investigates if SCA or its primary treatment, hydroxyurea, is associated with diminished ovarian reserve. A qualitative study of how women with SCA consider treatment choices which may compromise fertility augments the quantitative aims.

PI_NAMEs: PECKER, LYDIA  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Address;Adhesions;Adult;Affect;Age;Age Months;Age Years;Antral;Award;Biological Markers;Biometry;Blood Vessels;Body mass index;Brain Hypoxia-Ischemia;Case/Control Studies;Cessation of life;Characteristics;Child;Clinic;Clinical;cohort;comparison control;Contraceptive methods;Cross-Sectional Studies;Data;Data Collection;Decision Making;Development;diminished ovarian reserve;Disease;disease phenotype;Education;Epidemiology;Estradiol;Evaluation;experience;Extramural Activities;Female;female fertility;Fertility;fertility preservation;Focus Groups;Follicle Stimulating Hormone;Funding;Genotype;girls;Goals;Hematologist;Hemoglobin;Hemolytic Anemia;Heterozygote;Hormones;human old age (65+);hydroxyurea;hypoxic ischemic injury;infertility treatment;inflammatory marker;insight;Knowledge;Laboratories;life span;Longitudinal Studies;Measures;Mentors;Mentorship;Methodology;mullerian-inhibiting hormone;Multicenter Studies;multiorgan injury;Nursery Schools;Organ;organ injury;Ovarian;ovarian reserve;Ovary;oxidative damage;Participant;Patient Care;patient oriented;patient population;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Placebos;Positioning Attribute;preference;Pregnancy;Preparation;Principal Investigator;programs;prospective;Qualitative Methods;Qualitative Research;Race;Randomized;Records;reproductive;Reproductive Biology;Reproductive Health;Reproductive Medicine;Research;Research Design;Research Methodology;Resources;Risk;Sampling;Sickle Cell;Sickle Cell Anemia;skills;sperm cell;Surveys;theories;Therapeutic Uses;tool;Training;treatment choice;ultrasound;Uncertain Risk;willingness;Woman;Women's study;women's treatment;Work;young adult

PROJECT_TITLE: OVARIAN RESERVE IN POST-MENARCHAL FEMALES WITH SICKLE CELL ANEMIA

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Narrative:  Natural enzymes present exquisite control of efficiency and selectivity of chemical reactions, but how to predict enzyme variants to transform non-native chemical processes is broadly recognized as a “Holy Grail” in chemistry and biology because it will allow researchers to find effective enzyme variants to degrade environmental pollutants, conduct late-stage functionalization of drug molecules, and treat food allergies. Directed evolution has been widely applied to identify optimal enzyme variants for non-native reactions, but how to accelerate the screening cycles remains a critical roadblock due to the unknown relationship between sequence, structure, and kinetics for enzyme catalysis. My research program emphasizes developing computational platforms for the identification of function-enhancing enzyme variants to transform non-native enzymatic reactions, with an ultimate goal of delivering enabling computational tools for virtual prediction and design of function-enhancing enzyme variants for biomedical and biocatalytic uses.

PI_NAMEs: YANG, ZHONGYUE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;analog;Bacterial Antibiotic Resistance;Bacterial Infections;Biochemical Reaction;Biology;Catalysis;catalyst;chemical reaction;Chemicals;Chemistry;computational platform;computer infrastructure;Computer software;computerized tools;Data;data-driven model;Databases;design;Directed Molecular Evolution;Disease;drug-like compound;Electrostatics;Engineering;Environment;Environmental Pollutants;Enzymatic Biochemistry;Enzyme Interaction;Enzyme Kinetics;Enzyme Stability;enzyme structure;enzyme substrate;Enzymes;esterase A;Food Hypersensitivity;Goals;Haloacetate dehalogenase;Kinetics;machine learning model;Methods;Molecular;mutant;Mutation;non-Native;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;predictive tools;Process;programs;Protocols documentation;Quantum Mechanics;Reaction;Research;Research Personnel;S-Adenosylhomocysteine;S-Adenosylmethionine;screening;simulation;Solubility;Structure;tool;Transferase;Variant;Virtual Tool

PROJECT_TITLE: Developing Computational Tools for Predicting and Designing Function-Enhancing Enzyme Variants


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Signal transduction pathways underlie the very basis of life and are often critical targets for disease therapeutics. This work focuses on the molecular events of Notch signaling, which exerts a critical influence on cell differentiation in mammals and its misregulation is associated with diverse diseases, including the pathogenesis of many human cancers. This work will use two emerging technologies, proximity labeling and lattice light sheet microscopy, to provide unprecedented resolution in both space and time of the fundamental events required for transmission of physiologic Notch signals in living cells.

PI_NAMEs: BLACKLOW, STEPHEN C. (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: adaptive optics;Astrocytes;Binding;Biology;Cell Differentiation process;Cell membrane;Cell Nucleus;Cells;Chimeric Proteins;Coculture Techniques;Complex;Coupled;CRISPR/Cas technology;Cytoplasm;Disease;Emerging Technologies;endosome membrane;Engineering;Ensure;Event;Excision;experimental study;extracellular;Family;frontier;gamma secretase;Gene Expression;Genetic Transcription;Genome engineering;Genomics;Hour;Human;Imaging technology;in vivo;inhibitor;Ions;Kinetics;Knock-in;Knowledge;Label;Laboratories;Life;Ligands;Light;Location;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Measures;Membrane;Microscopy;Modeling;Molecular;Monitor;Movement;notch protein;optical lattices;Optics;Output;Pathogenesis;Pathogenicity;Pathway interactions;Physiological;Process;Proteins;Proteolysis;Proteomics;receptor;Receptor Activation;recruit;Resolution;response;Scanning Electron Microscopy;Series;Signal Transduction;Signal Transduction Pathway;Site;spatiotemporal;stoichiometry;System;Technology;Therapeutic;Time;transmission process;Travel;Visualization;Visualization software;Work

PROJECT_TITLE: Dynamics of Notch Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Infertility;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Current U.S. guidelines recommend a daily “baby” aspirin, begun after the first trimester, to prevent preeclampsia. However, data suggest that a higher dosage of aspirin and initiating treatment immediately upon pregnancy recognition, instead of waiting until 12 weeks' of pregnancy, may have a greater beneficial effect, while additionally protecting against pregnancy loss. We propose a randomized trial of 162 mg aspirin (equivalent to two “baby” aspirin) begun by 6 weeks' gestation in a diverse population to evaluate its effect on preventing pregnancy loss and preeclampsia.

PI_NAMEs: BARNHART, KURT T;SCHISTERMAN, ENRIQUE F. (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Advisory Committees;Affect;Area;Aspirin;Biometry;black women;Cessation of life;Clinical;clinical care;Clinical Trials;Conceptions;Dangerousness;Data;Discipline of obstetrics;dosage;Dose;Double-Blind Method;Early Diagnosis;Ensure;First Pregnancy Trimester;follow-up;Guidelines;Gynecologic;Health;Hospitals;Hypertension;implantation;improved;Intervention;Intervention Trial;Literature;Machine Learning;machine learning method;Medicine;metropolitan;Minority;Monitor;Morbidity - disease rate;novel;optimal treatments;Outcome;Patient Recruitments;Patients;Pennsylvania;Perinatal;Perinatal Epidemiology;Persons;Phenotype;Philadelphia;Placebos;Placenta;Placentation;Population;Population Heterogeneity;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy loss;Pregnancy Outcome;Pregnancy Tests;pregnant;prevent;Prevention;Preventive service;Primary Prevention;Protocols documentation;psychologic;randomized trial;Recommendation;recruit;reproductive;reproductive outcome;Research;Risk;Sampling;secondary outcome;Shoulder;Spontaneous abortion;standard of care;System;targeted treatment;Time;Underrepresented Minority;United States Preventative Services Task Force;Universities;Vascularization;Woman

PROJECT_TITLE: Early Double Low-Dose Aspirin to Reduce Preeclampsia and Miscarriage: a Global Approach RCT

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

PHR: Project Narrative  The proposal aims to fill critical gaps in knowledge regarding the structural and mechanistic understanding of the cap-independent translation initiation in (+)-sense RNA viruses, many of which are the etiological agents for causing various human diseases and several global pandemics. The outcomes of this research promise to aid in developing RNA-targeted therapeutics against these pathogens, thus enhancing human health globally.

PI_NAMEs: KOIRALA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Adopted;Affinity;Animal Diseases;Binding;Binding Sites;Cactaceae;Cardiovirus;Cells;Complex;Coxsackie Viruses;Crystallization;Data;Development;Distant;Enhancers;Etiology;Fab Immunoglobulins;Family;Genome;global health;Goals;Hepatitis A Virus;Human;human disease;insight;Internal Ribosome Entry Site;Knowledge;Messenger RNA;Molecular Chaperones;Outcomes Research;pandemic disease;Parents;pathogen;Peptide Initiation Factors;Plant Diseases;Postdoctoral Fellow;Process;recruit;Resolution;Ribosomes;RNA;RNA Probes;RNA Viruses;RNA-targeting therapy;Shapes;Structure;Technology;three dimensional structure;Tombusviridae;Tombusvirus;Translation Initiation;Translations;Viral;viral RNA;Virus;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural and mechanistic studies of cap-independent genome translation in (+)-strand RNA viruses


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Pain Research;Substance Misuse

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Chronic pain is a condition that persists beyond the time required for normal tissue healing or arises in the absence of a discernable tissue insult, suggesting that it is a phenomenon mediated by the central nervous system. The proposed research will detail how neuronal plasticity within the central nervous system perpetuates pain perception during a chronic pain experience. This work will therefore provide a potential target for novel pain therapies.

PI_NAMEs: CONDON, LOGAN FRANCIS (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;allodynia;Animals;Automobile Driving;Behavior;Biological Assay;Calcium;calcium indicator;Cell Nucleus;Cells;Central Nervous System;Chronic;chronic pain;chronic pain management;chronic painful condition;cohort;Cre driver;Data;designer receptors exclusively activated by designer drugs;Disinhibition;Event;excitatory neuron;Exhibits;experience;experimental study;Face;Fibromyalgia;FOS gene;Frequencies;Functional disorder;Genes;Genetic Markers;Goals;Head;healing;Image;Immediate-Early Genes;Implant;In Situ Hybridization;in vivo calcium imaging;inflammatory pain;Injury;interest;Investigation;Lead;lens;Ligands;Ligation;Mediating;Methodology;Migraine;Modeling;Mus;Nerve;neural;Neuronal Plasticity;Neurons;neurotransmitter release;new therapeutic target;Nociceptors;Normal tissue morphology;novel;Opioid;Opsin;Pain;pain behavior;Pain management;Pain Measurement;pain model;pain perception;pain symptom;painful neuropathy;parabrachial nucleus;peptide hormone;Persistent pain;Pharmaceutical Preparations;Play;Population;prevent;Proxy;Publications;Research;response;Role;sciatic nerve;Sensory;side effect;Spinal;Spinal Cord;Stimulus;Syndrome;Target Populations;Techniques;Tension Headache;Testing;Tetanus Toxin;Time;Tissue Fixation;tissue injury;Tissues;Trigeminal Nuclei;two-photon;Viral Vector;Work

PROJECT_TITLE: Delineating how Calca neurons in the parabrachial nucleus mediate chronic pain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Men and women are differentially vulnerable to the development and sustainment of cocaine use disorder, and women represent the population most at risk. Dysregulation of the dopamine system is critical in the expression of sex-specific behaviors implicated in addiction. Results from this project will characterize sex-differences in the regulation of dopamine release and will provide a better understanding for pharmacotherapeutic approaches for SUD treatment in both males and females.

PI_NAMEs: CHRISTENSEN, BROOKE A. (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Ablation;Action Potentials;addiction;Address;Affect;Agonist;antagonist;Behavior;Brain;Brain region;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine exposure;cocaine related behaviors;cocaine self-administration;Cocaine use disorder;Coupled;Data;Development;Disease;Dopamine;dopamine system;dopaminergic neuron;efficacious treatment;Evidence based intervention;experimental study;FDA approved;Feedback;Female;GABA Receptor;GABA-A Receptor;GABA-B Receptor;gamma-Aminobutyric Acid;Goals;Individual;Intervention;Knock-out;Learning;Link;male;Mediating;men;Mus;neuromechanism;neurotransmission;Nucleus Accumbens;Optics;Pharmaceutical Preparations;Pharmacology;Play;Population;prevent;Probability;Process;Property;receptor;receptor expression;Regulation;Rewards;Risk;Role;sensor;sex;Sex Differences;sexual dimorphism;Slice;System;Thinking;Time;Training;virtual;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Defining sex differences in GABA regulation of dopamine release in cocaine use disorder


ORG_NAME: GEORGIA STATE DEPARTMENT OF AGRICULTURE

PHR: NARMS Project Narrative The Georgia Department of Agriculture’s Labs will work with their regulatory partners to collect targeted food sample and test them for the selected microbes identified in the NARMS FOA. These samples will be collected throughout the State of Georgia (or per FDA directive) from retail establishments to ensure data collected is representative of region. In addition, assistance from Georgia Department of Public Health Labs will perform any necessary Whole Genome Sequencing. Isolates and data collected from this project will be forwarded to FDA so that they can combat antibiotic resistance threats in food commodities.

PI_NAMEs: CRABTREE, CARRIE  (contact)

PROJECT_TITLE: Ga. Dept. of Agriculture - NARMS


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative The overall objective of our proposal is to protect and promote public health by enhancing and strengthening the surveillance of antimicrobial resistant (AMR) Salmonella, Campylobacter, Escherichia coli, Vibrio, Aeromonas, lactose fermenters, and Enterococcus spp. in retail food specimens in North Carolina and generate critical data to contribute to the NARMS mission. The generation of WGS profiles will allow us to track pathogens nationally and globally and assist in preventing foodborne outbreaks and safeguarding public health.

PI_NAMEs: THAKUR, SIDDHARTHA  (contact)

PROJECT_TITLE: Monitoring antimicrobial resistance (AMR) in enteric pathogens isolated from retail meats and seafoods in North Carolina


ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE DEPARTMENT OF HEALTH

PHR: Project Narrative A comprehensive approach must address AR in humans, food animals, and retail food. Tennessee has proven performance and desires to partner with FDA and other RFS sites to enhance the program. We hope that our response to this FOA will be favorably considered.

PI_NAMEs: HANNA, SAMIR  (contact)

PROJECT_TITLE: NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01) Clinical Trials Not Allowed


ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Antimicrobial resistance (AMR) is a significant public health concern. The National Antimicrobial Resistance Monitoring System (NARMS) conducts national surveillance of AMR in retail raw meat and seafood and provides critical information for mitigating AMR. By continuing our partnership with the NARMS as a network laboratory, our work will enhance NARMS effort in the surveillance of AMR in retail meat/seafood, and thus will contribute to mitigation of AMR in the food chain and consequently to enhancement of food safety and public health.

PI_NAMEs: SAHIN, ORHAN  (contact)

PROJECT_TITLE: Detection and surveillance of antimicrobial resistance among enteric bacteria from raw retail meat and seafood in Iowa: A NARMS Retail Food Surveillance Project


ORG_CITY: PORTLAND

ORG_NAME: PUBLIC HEALTH SERVICES

ORG_STATE: OR

PHR: Narrative The OSPHL participates in the FDA’s National Antimicrobial Resistance Monitoring System Retail Meat Program to monitor pathogens and the food supply and identify emerging public health threats. This study funds the lab’s collection and analysis activities, to provide data to state and federal epidemiologists for foodborne illness investigation and response.

PI_NAMEs: SAITO, AKIKO  (contact)

PROJECT_TITLE: Oregon State Public Health Laboratory Participation in the FDA NARMS Retail Meat Program


NIH_SPENDING_CATS: Brain Disorders;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Recent advances of spatial technologies enable the elucidation of single-cell spatial heterogeneity, with unprecedented opportunities to decipher the underlying mechanisms of disease etiology and drug therapeutics. However, there is a lack of computational methods that leverage the strengths of data from different sources (e.g., genomics, epigenomics, clinical data) to achieve multi-modal insights into the spatially distributed cells. In this project, we propose to develop a series of computational methods to recover the full picture of spatial profiles, unleash the power of spatial profiles for deciphering the regulatory mechanisms underpinning diseases and drug response.

PI_NAMEs: SONG, QIANQIAN  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Biological;Biological Process;Biomedical Research;Cells;Clinical Data;Collaborations;Communities;Complex;Comprehensive Cancer Center;computer framework;Computing Methodologies;Data;deep learning;Diagnosis;Disease;disorder prevention;drug response prediction;empowerment;Epigenetic Process;epigenomics;Etiology;Genetic;genome wide association study;Genomics;Goals;Heterogeneity;insight;Joints;knowledge base;laboratory experiment;Location;Machine Learning;Metastatic malignant neoplasm to brain;Methodology;Methods;Molecular;multidisciplinary;multimodality;Multiomic Data;multiple data sources;novel;open source;personalized biomarkers;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;precision medicine;programs;Research;response;Series;Slice;Software Tools;Source;statistical learning;Statistical Methods;Technology;Therapeutic;Tissues;Training;transcriptomics;transfer learning;Work

PROJECT_TITLE: Multi-modal insights of spatially distributed cells with associations of diseases and drug response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Data Science;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This K02 Independent Scientist Award will provide protected research time for the PI to develop an integrated program of brain-based and behavioral research on substance use disorders (SUD), especially cannabis use disorder (CUD). This award will provide protected time for training in (1) statistical analysis as it pertains to big data, in light of the shift in the neuroimaging field toward large consortia-collected datasets, and (2) developmental neuroscience. This training will enhance the PI’s laboratory through significantly expanding the questions she can address, improving her analytic skills, furthering her ability to collaborate, and providing a solid and growing foundation for mentoring junior scientists.

PI_NAMEs: GILMAN, JODI  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Age;Anxiety;Area;Award;Behavior assessment;Behavioral;behavioral outcome;Behavioral Research;Big Data;Brain;brain based;Cannabis;career;career development;Child;Childhood;Chronic;Clinical Trials;Cognition;cognitive development;Collaborations;Data;Data Set;Data Storage and Retrieval;detection method;Development;disorder risk;Drug usage;Educational process of instructing;experimental study;Factor Analysis;Foundations;Funding;Future;Goals;Growth;Image;improved;Impulsivity;Independent Scientist Award;indexing;Knowledge;Laboratories;large datasets;Lasso;Learning;life span;Light;longitudinal dataset;machine learning prediction;marijuana use disorder;Measures;Medical Marijuana;Mental Depression;Mentors;Methods;Modeling;neural;neural correlate;neuroimaging;neuroimaging marker;Neurosciences;Pain;parallel computer;Parents;Participant;Patient Self-Report;Patients;Phase;Population;predictive modeling;programs;Reporting;Reproducibility;Research;Research Project Grants;Risk;Risk Factors;Running;Sampling;Scanning;Scientist;skills;Solid;Statistical Data Interpretation;Structure;substance use;Substance Use Disorder;Techniques;Testing;theories;Thinness;Time;tool;Training;Validation;vector;Visit;Wages;Work

PROJECT_TITLE: Using Neuroimaging Markers to Understand Risk Factors and Consequences of Cannabis on Brain Structure and Function

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Mental Illness;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Many cardiac arrest (CA) patients now survive neurologically intact, but evidence from the new field of CA survivorship research suggests that cardiac anxiety, physical inactivity, and poor sleep are common—and may increase survivors' high cardiovascular and mortality risk. This will be the first cohort study of CA survivors to comprehensively assess psychological distress, objectively monitor physical activity and sleep, and rigorously adjudicate cardiovascular events and mortality at 12 months after hospital discharge. In a diverse group of CA survivors, we will estimate the prospective association of cardiac anxiety and behavioral factors with CVD event-free survival and quality of life, to provide the most rigorous data to date on psycho-behavioral contributors to secondary risk in CA patients.

PI_NAMEs: AGARWAL, SACHIN  (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Accelerometer;actigraphy;Acute;acute coronary syndrome;adjudication;Adoption;American Heart Association;Anxiety;anxiety symptoms;avoidance behavior;Behavior;Behavioral;Brain Injuries;Cardiac;Cardiopulmonary Resuscitation;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Chronic Disease;Clinical;Clinical Management;clinical practice;clinically relevant;Cognition;Cognitive;cohort;Cohort Studies;Coma;Coronary heart disease;Data;Defibrillators;Depression screen;Development;disability;disease prognosis;Disease Progression;Disease-Free Survival;Distress;Enrollment;Event;follow-up;Fright;generalized anxiety;Generations;Guidelines;hazard;Health;health assessment;Health behavior;Health Campaign;health related quality of life;Healthcare;Heart;Heart Arrest;heart dimension/size;Heart Rate;Home;Hospitalization;Hospitals;Hour;improved;Induced Heart Arrest;Inpatients;Intervention;Knowledge;Learning;Literature;Measures;Mediating;Medical;Mental Depression;Modification;Monitor;mortality;mortality risk;Nervous System Physiology;Neurologic;Participant;Patients;Physical activity;Physical assessment;physical inactivity;Physiological;poor sleep;portability;Post-Traumatic Stress Disorders;Prevalence;primary outcome;Prognosis;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Protocols documentation;psychologic;psychological distress;psychosocial;Psychosocial Assessment and Care;Public Health;Quality of life;Recommendation;recruit;Registries;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;Risk Reduction;Role;Sample Size;secondary analysis;secondary outcome;Secondary Prevention;Secondary to;Secure;Seminal;Sex Differences;SF-12;Shortness of Breath;Signal Transduction;Sleep;Sleep disturbances;Stroke;Survival Rate;Survivors;survivorship;Symptoms;Telephone;Testing;Update;Work;Wrist

PROJECT_TITLE: Characterize psychological and behavioral dimensions of cardiac arrest survivorship, and their association with 1-year mortality, cardiovascular disease risk, and health-related quality of life

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Adoptive cell therapies using receptor engineered cells have been highly effective at curing cancers of the blood and are currently being extended to the treatment of a wide range of diseases including chronic viral infections, autoimmune diseases, and other cancers. Cell-based therapeutics are living drugs, and a major challenge to creating them for new disease indications is a lack of precise control, leading to off-target effects and overactivity, potentially causing deadly toxicities. We are developing general strategies to precisely control receptor engineered cells through chemical ON- and OFF-switches that enable temporal control by pharmacological agents and added specificity through sensing of distinct disease signals.

PI_NAMEs: LOHMUELLER, JASON JAKOB (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acidosis;Address;Adoptive Cell Transfers;Adoptive Transfer;Antibodies;antigen binding;Antigen Receptors;Antigen Targeting;Antigens;Area;Autoimmune Diseases;Biological;Biological Process;biological systems;Biology;blood treatment;Cell Therapy;Cells;cellular engineering;Characteristics;chemical group;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;Collaborations;combinatorial;covalent bond;design;Development;Disease;engineered T cells;Engineering;Enzymes;experience;Foundations;Genes;genetically modified cells;Goals;Hematopoietic Neoplasms;Human;improved;In Vitro;in vivo;interest;Label;Lead;Logic;Malignant Neoplasms;Manuscripts;Medical;Methods;Modality;mouse model;notch protein;novel;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;programs;receptor;Receptor Activation;receptor binding;Receptor Signaling;response;Response to stimulus physiology;Safety;Signal Transduction;Site;small molecule;SNAP receptor;Solid Neoplasm;spatiotemporal;Specificity;Stimulus;Synthetic immunology;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;Therapeutic antibodies;Therapeutic Effect;Toxic effect;tumor xenograft;Validation;Virus Diseases;Xenograft procedure

PROJECT_TITLE: Conditional control of universal antigen receptor signaling

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Heart Disease;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The drive to be “person-centered” in the care of patients in advanced cardiac care is both intuitive and politically popular – enjoying explicit support from the IOM, AMA, AGS, ACC, FDA, the UN High Commissioner for Human Rights, in the Patient Protection & Affordable Care Act, and elsewhere. Optimal means by which to be patient centered in the real-world, however, is unknown. Critically examining the ways in which healthcare providers assess patient values will be necessary to innovate the manner in which this assessment occurs and is integrated into care for patients. The overarching objective of this career development award is to continue the professional and methodologic growth of Christopher Knoepke, PhD, MSW, LCSW, into an independent clinical social work scientist leading the field of cardiology toward improved patient-centered care by means of 1) contextually-appropriate qualitative assessment of patient values in clinical settings; 2) understanding what clinical providers need in order to actually implement improved values clarification methods into practice; and 3) studying the effectiveness and implementation integration of new models of patient decision support using pragmatic trial techniques.

PI_NAMEs: KNOEPKE, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;advanced disease;Affordable Care Act;aortic valve replacement;Area;Attitude;Audiotape;Award;Benefits and Risks;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;care delivery;care providers;Caring;Clinical;clinical encounter;clinical practice;Collaborations;Colorado;comorbidity;Complex;contextual factors;Decision Aid;Decision Making;Decision Support Model;design;Development;Dissemination and Implementation;Doctor of Philosophy;Education;Educational workshop;effectiveness/implementation study;Elderly;Emotional;empowerment;Ensure;Environment;Goals;Grant;Growth;Health;Health Personnel;Health Services Research;high risk;Human Rights;implementation evaluation;implementation science;improved;individualized medicine;innovation;interest;Intervention;Interview;Intuition;K-Series Research Career Programs;Knowledge;Learning;Licensing;marginalization;Medical;medical schools;medical specialties;Medical Technology;Mentors;Mentorship;Methodology;Methods;Modeling;National Heart, Lung, and Blood Institute;new technology;novel;Outcomes Research;Patient Care;Patient Education;patient oriented;Patient-Centered Care;Patients;Perception;person centered;pilot test;Politics;Positioning Attribute;pragmatic trial;professor;Provider;Qualitative Methods;Qualitative Research;Research;Research Activity;Research Assistant;Sampling;Science;Scientist;shared decision making;Social Work;Social Workers;Specialist;Stigmatization;Study models;support tools;surgical risk;Survey Methodology;Surveys;Techniques;Technology;Testing;Training;Training Activity;Translating;trend;Universities;Washington;Work

PROJECT_TITLE: Decision Support for Older and Frail Patients Considering Advanced Cardiovascular Therapies: Improving Models of Personal Values Clarification


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Non-cigarette tobacco products have the potential to reduce harm for smokers who want to quit but cannot. The proposed trial will evaluate whether e-cigarettes and heated tobacco product are able to promote abstinence from smoking compared to FDA-approved pharmacotherapy for smoking cessation. The results of the proposed trial will provide information about whether these products have utility for reducing harm among adult smokers who cannot quit smoking.

PI_NAMEs: SMITH, TRACY TAYLOR (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Abstinence;Address;Adult;behavioral outcome;Biochemical;Biological Markers;Carbon Monoxide;Centers for Disease Control and Prevention (U.S.);Chemicals;Cigarette;Cigarette Smoker;cigarette smoking;Clinical Trials;combustible cigarette;Communities;Data;design;Electronic cigarette;evidence base;Exposure to;FDA approved;follow-up;Harm Reduction;Health;Health Benefit;heated tobacco products;improved;Instruction;Measures;Methods;Nicotine;nicotine exposure;nicotine replacement;Nitrosamines;non-cigarette tobacco product;novel;Outcome;Participant;Patient Self-Report;Pharmaceutical Preparations;Pharmacotherapy;Play;primary outcome;Randomized;randomized, clinical trials;recruit;Research;respiratory health;Respiratory Signs and Symptoms;Risk;Role;Sales;secondary outcome;Smoke;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Spirometry;success;Tobacco;tobacco abstinence;tobacco products;Tobacco use;tool;Toxicant exposure;United States Food and Drug Administration;urinary;varenicline

PROJECT_TITLE: Non-Cigarette Tobacco Products as Harm Reduction Tools in Smokers Who Failed to Quit With Traditional Methods

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Narrative: Chronic pain remains a significant clinical problem. Current treatments have limitations such as development of tolerance and abuse potential. Thus, there is a need to identify new therapeutic targets. The pathways via which brain perceives pain undergo significant functional changes during persistent pain. However, the key components of synapses within these pathways and their roles in persistence of pain are not well understood. We propose to understand the role of a type of glutamate receptor which appears to be critical for maintaining key nodes in the pain pathways.

PI_NAMEs: DRAVID, SHASHANK MANOHAR (contact);NEUGEBAUER, VOLKER

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 3-Dimensional;abuse liability;Address;Affect;Affective;American;Amygdaloid structure;Anxiety;anxiety-like behavior;Axosomatic Synapse;Behavior;Biochemical;Biological;Brain;Calcitonin Gene-Related Peptide;cell type;chronic pain;Clinical;comorbidity;Complex;confocal imaging;Confocal Microscopy;Data;delta receptors;Dendrites;Development;Down-Regulation;Drug Addiction;economic cost;Electron Microscopy;Electrophysiology (science);Elements;Emotional;Equilibrium;Experimental Designs;experimental study;Foundations;Frequencies;Freund's Adjuvant;Functional disorder;Genetic;genetic approach;genetic manipulation;Glutamate Receptor;Glutamates;Health Care Costs;Hypersensitivity;Image;imaging approach;Impaired cognition;Impairment;Incidence;Inflammatory;inflammatory pain;Infusion procedures;Injections;Ion Channel;Knockout Mice;Knowledge;Laboratories;Lateral;Ligation;Long term disability;Maintenance;Mechanics;Mediating;Mental Depression;Messenger RNA;Methods;Modeling;Molecular;Mus;neuronal cell body;Neuronal Plasticity;Neurons;Neuropathy;new therapeutic target;Nociception;novel;optogenetics;overexpression;Pain;pain behavior;Pain management;pain model;pain processing;pain reduction;pain relief;pain signal;painful neuropathy;parabrachial nucleus;Pathway interactions;Peripheral;Persistent pain;Pharmaceutical Preparations;Play;postsynaptic;Precipitation;presynaptic;Presynaptic Terminals;Productivity;protein kinase C-delta;Reagent;receptor;receptor expression;Recombinants;Research;Research Design;restoration;Role;Sensory;sex;side effect;Signal Transduction;Slice;Somatostatin;Spinal nerve structure;Structure;Synapses;synaptic function;Synaptic plasticity;System;Techniques;Testing;transmission process;Viral;vocalization

PROJECT_TITLE: Trans-synaptic signaling complex in amygdala pain mechanisms


ORG_CITY: COLUMBIA

ORG_NAME: SOUTH CAROLINA DEPARTMENT OF PUBLIC HEALTH

PHR: SC DHEC PHL-NARMS Narrative The South Carolina Department of Health and Environmental Control (SC-DHEC) , Public Health Laboratory (PHL), serves as the state public health Laboratory, working towards improving the quality of life for South Carolinians by protecting and promoting the health of the public and the environment. The purpose of this project is to increase surveillance for antibiotic resistance in enteric bacteria from retail meat and seafood samples. During this cooperative agreement, the Food Microbiology Laboratory will maintain laboratory capacity by continuing to implement NARMS retail meat and seafood surveillance protocols. Testing will be performed bimonthly with 20 retail meat samples being tested at each time point and 8 seafood samples being tested monthly. The SC-DHEC PHL will follow all protocols provided by the Food and Drug Administration (FDA). Bacteria isolated from retail meat and seafood samples will be characterized where appropriate by serology, whole genome sequencing (WGS), and sent to the FDA Center for Veterinary Medicine (FDA-CVM) for antibiotic sensitivities. Results will be shared with the Center for Disease Control (CDC), the FDA, and DHEC Foodborne Epidemiologists. Data will be used to drive identification of foodborne disease outbreaks. Antibiotic resistance data collected, as a result of the surveillance activities, will be analyzed and monitored for trends. Data will be disseminated to state epidemiologists, and when appropriate, State Sentinel Hospitals. These activities performed in support of this cooperative agreement will strengthen national efforts to monitor antimicrobial resistance among enteric bacteria isolated from retail meats and seafood and provide data to drive public health policy and program development.

PI_NAMEs: DAVIS, MEGAN  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOISE

ORG_NAME: BOISE VA MEDICAL CENTER

ORG_STATE: ID

PHR: More than 25% of Veterans have type 2 diabetes compared with 8% in the general population in the U.S. Diabetic Veterans are at a higher risk for complications from numerous infectious diseases, including severe viral respiratory tract infections, such as those caused by SARS-CoV-2 (COVID), influenza and adenovirus. For example, diabetic patients account for over 30% of the hospitalizations from influenza and are more likely to have worse clinical outcomes from other severe viral respiratory tract infections. Survival from these severe infections often results in altered lung structure which can impair lung function and increase the long-term risks of pneumonia, hospitalization, and death in diabetic Veterans. The goal of this project is to develop a diabetic animal model to study the basic mechanisms of the damaging inflammation associated with human respiratory virus-induced lung injury in diabetics. This increased understanding can be used as a basis for advances in therapeutic interventions to prevent related short-term and long-term lung dysfunction in Veterans.

PI_NAMEs: RADKE, JAY R (contact)

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adenovirus Protein;Adenoviruses;Affect;Alveolar Macrophages;Animal Model;Anti-Inflammatory Agents;Blood Glucose;Bronchopneumonia;candidate identification;cell growth regulation;Cells;Cessation of life;chemokine;Clinical;Communicable Diseases;comparative;Comparative Study;COVID-19;COVID-19 severity;cytokine;Data;Death Rate;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diet;Disease;Disease Outbreaks;effective therapy;emerging virus;Etiology;experimental study;Fatty acid glycerol esters;Functional disorder;Future;Gene Expression Profile;General Population;Genes;Glycolysis;Goals;Hamsters;high risk;Hospital Mortality;Hospitalization;Human;immune cell infiltrate;Immune response;immunoregulation;Impairment;In Vitro;in vivo;Incidence;Individual;Infection;Infection prevention;Inflammation;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;influenza virus strain;Innate Immune Response;innovation;Lung;Lung infections;lung injury;Macrophage;Mediating;Mesocricetus auratus;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolomics;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Outcome;pandemic disease;Pathogenesis;Pathogenicity;Patients;Pattern;permissiveness;Phenotype;Play;Pneumonia;prevent;Production;Proteomics;prototype;pulmonary function;Pulmonary Inflammation;Reporting;Repression;Resistance;Resolution;respiratory;respiratory virus;response;Risk;Rodent;Role;SARS coronavirus;SARS-CoV-2 infection;Seasons;Signal Repression;Signal Transduction Pathway;single-cell RNA sequencing;Structure;sugar;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;transcriptomics;Veterans;Viral;Viral Pathogenesis;Viral Respiratory Tract Infection;virology;Virus;Virus Diseases;western diet

PROJECT_TITLE: Role of macrophages and miRNA in regulating lung macrophage polarization and lung pathogenesis during respiratory virus-induced acute lung injury in normal and diabetic Syrian hamsters.


ORG_CITY: DAVIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative This project is relevant to public health because the project will survey antimicrobial resistance among bacteria in retail foods in the state of California. The project is relevant to FDA’s mission in that the outcome of the project will enhance and sustain FDA’s surveillance and research of antimicrobial resistance in retail foods and strengthen collaborations among federal and state agencies and universities on research, detection, surveillance, and investigation of foodborne disease. 1

PI_NAMEs: LI, XUNDE  (contact)

PROJECT_TITLE: Extending NARMS surveillance of antibiotic resistance in retail foods in California


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Chronic lung disease due to non‐tuberculous mycobacteria is a silent and emerging epidemic. The proposal aims to design and develop a new class of spectinomycin analogs to treat these intrinsically drug‐resistant infections, starting from analogs which have already shown much promise in animal infection models.

PI_NAMEs: LEE, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Acute;Amikacin;Aminoglycosides;analog;Animals;Antibiotics;Bacterial Proteins;Binding;Binding Proteins;Binding Sites;biological adaptation to stress;Biological Assay;Biology;Chemistry;Chronic;Chronic lung disease;Clarithromycin;Clinical;Complement;Complex;counterscreen;Cryoelectron Microscopy;cytotoxicity;Data;design;Development;Disease;Drug Design;Drug Kinetics;Drug resistance;efficacy study;emerging pathogen;Ensure;Enzymes;Ethylenes;Exhibits;Extreme drug resistant tuberculosis;Generations;Genetic Transcription;genome sequencing;Genus Mycobacterium;Goals;Human;In Vitro;in vitro activity;in vivo;Infection;Libraries;Link;lipophilicity;liver metabolism;Lung;Maximum Tolerated Dose;member;Methods;Minimum Inhibitory Concentration measurement;Mitochondrial Proteins;Modeling;Modification;mouse model;Multi-Drug Resistance;Mus;Mutagenicity Tests;mutant;mycobacterial;Mycobacterium abscessus;Mycobacterium avium;Mycobacterium Infections;new epidemic;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel therapeutics;Organoids;Outcome;pathogen;Pathogenicity;Pathology;Pathway interactions;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Predisposition;Property;Protein Synthesis Inhibition;Proteins;Refractory;Research Personnel;Resistance;resistance mechanism;response;Ribosomes;Safety;safety study;safety testing;Side;Spectinomycin;standard of care;Structure;Testing;Therapeutic;transcriptome sequencing;Translational Repression;Translational Research;Treatment Efficacy;Virulence;whole genome

PROJECT_TITLE: Spectinomycin analogs for NTM infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because the hippocampus and its specific subfields are implicated in memory deficits and neurodevelopmental disorders resulting from early life adversity. Obtaining accurate estimates of hippocampal subfield development and identifying the effects of socioeconomic disparities related to adversity in large samples has the potential to establish hippocampal subfield volumes as candidate markers for those at risk for neurodevelopmental disorders and for development of early targeted intervention with the highest potential efficacy.

PI_NAMEs: CANADA, KELSEY LEIGH (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 4 year old;Acceleration;Address;Adolescence;Adult;Age;Autopsy;behavioral outcome;Brain;candidate marker;Caring;Childhood;cognitive ability;cognitive development;Communities;community intervention;Data;Data Analyses;data integration;dentate gyrus;Development;Distress;early childhood;Early identification;early life adversity;Education;Environment;Environmental Risk Factor;Future;Geography;Goals;high resolution imaging;Hippocampus;Household;Human;Income;indexing;Individual;Intervention;Learning;Link;Literature;longitudinal dataset;low socioeconomic status;Measures;Medical;Memory;Memory impairment;Mental Depression;Methodology;Methods;middle childhood;Modeling;Neighborhoods;Neurodevelopmental Disorder;neuroimaging;novel;Occupations;Population;Procedures;Protocols documentation;Proxy;Public Health;Research;Resources;Risk;Sample Size;Sampling;Sampling Studies;Scanning;Schizophrenia;Site;social capital;socioeconomic disparity;Socioeconomic Status;socioeconomics;Stress;Structure;Testing;ultra high resolution;United States;Variant;Work;young adult

PROJECT_TITLE: An integrative multisite study of the influence of socioeconomic disparities on hippocampal subfields developmental trajectories


NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The Johns Hopkins University seeks to strengthen the coordination of new and innovative research and practice efforts in maternal health through collaboration with the National Institutes of Health and their Implementing a Maternal Health and Pregnancy Outcomes Vision for Everyone (IMPROVE) initiative grantees. The overarching goals of this project are to establish and maintain a Maternal Health Data Innovation and Coordination Hub to support Maternal Health Research Centers of Excellence, and to facilitate the reuse of the data they generate.

PI_NAMEs: CREANGA, ANDREEA ALINA (contact);NAGY, PAUL GREGORY

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Area;Artificial Intelligence;Award;Bioethics;career development;Centers of Research Excellence;Clinical;cloud based;Collaborations;Common Data Element;Communication;Communities;Data;Data Analyses;Data Collection;data hub;data integration;data modeling;data repository;data reuse;Data Science;Data Set;data sharing;Data Storage and Retrieval;Development;Documentation;Equity;Evaluation;experience;FAIR principles;Family;Fostering;Funding;Generations;Goals;health data;health disparity;health economics;health equity;Human;implementation science;improved;Informatics;Infrastructure;Ingestion;innovation;interest;Knowledge;Machine Learning;Maternal Health;Medical;medical schools;Mentorship;Methods;multidisciplinary;Observational Study;Ontology;open source;Outcome;patient safety;Patients;Peer Review;Population Heterogeneity;precision medicine;Pregnancy Outcome;Preparation;Process;programs;Public Health Schools;quality assurance;Recommendation;Registries;Reporting;repository;Reproducibility;Research;Research Project Grants;Research Support;Resources;Scholarship;Secure;Security;Site;skills;Specialist;Standardization;Statistical Data Interpretation;symposium;Techniques;Terminology;tool;Training;United States National Institutes of Health;Universities;Vision;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(70)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The Add Health Parent Study (AHPS) is an innovative project in which a multiethnic/racial and interdisciplinary team of scientists will collect longitudinal cognitive, social, behavioral, and biological data on parents of the members of the National Longitudinal Study of Adolescent to Adult Health (Add Health). The proposed Phase 2 of AHPS will increase the samples of Non-Hispanic Black and Hispanic parents in AHPS, consent and ad- minister an Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) Assessment, collect DNA, link longitudinal AHPS data to longitudinal Add Health data, harmonize cognitive measures across the two generations, assemble a multigenerational genomic database, and make these new data available to the scientific community of 50,000+ Add Health and AHPS users. This project will facilitate the study of racial/eth- nic disparities in cognitive aging, caregiving, and AD/ADRD risk across two generations with longitudinal, na- tionally representative data collected from adult children and their parents.

PI_NAMEs: BOERWINKLE, ERIC A.;DUKE, NAOMI N;HARRIS, KATHLEEN MULLAN (contact);HOTZ, VINCENT JOSEPH;PERREIRA, KRISTA M

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adolescent;Adult;Adult Children;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavior;Behavioral;Biological;Biological Factors;Biosocial;Black race;Blood;caregiving;Child;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Collection;Communities;Consent;Data;Data Collection;data resource;Databases;dementia risk;design;Development;Dimensions;Discrimination;Disparity;DNA;DNA Methylation;Documentation;Dryness;Economics;Education;Environment;epigenetic clock;ethnic difference;ethnic disparity;Ethnic Population;Etiology;experience;family caregiving;Generations;Genes;Genetic Processes;genomic data;Genomic Library;Genomics;Health;health data;health economics;healthy aging;high risk;Hispanic;Impaired cognition;indexing;innovation;insight;instrument;intergenerational;Interview;Investigation;Knowledge;Lateral;Link;Longitudinal Studies;Measurement;Measures;member;middle age;multi-ethnic;National Longitudinal Survey of Adolescent to Adult Health;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;offspring;Parents;Participant;Pattern;Phase;phase 1 study;phase 2 study;Population;Preventive;Process;protective factors;Protocols documentation;Race;racial difference;racial disparity;racial population;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Respondent;Risk;Role;Saliva;Sample Size;Sampling;Sampling Studies;Scientist;SNP genotyping;social;social stigma;socioeconomics;Specimen;Spottings;Spouses;Surveys;Time;Weight;whole genome

PROJECT_TITLE: Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative The SHort Course In TransFerable Skills Training (SHIFT) Program is designed to enhance the ability of underrepresented minority trainees to transition into successful careers in biomedical science by providing them with mentoring and professional development training (e.g., marketing, relationship building, project management, and budgeting). Moreover, this one-year national training program will address efforts to diversify the biomedical workforce by equipping a new generation of underrepresented in biomedical research trainees with skills requisite for successful careers in biomedical science.

PI_NAMEs: LINDSEY, MERRY L. (contact);WOODS, LETHA

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Agreement;Area;Biomedical Research;Books;Brain;Budgets;career;career development;Career Mobility;Case Study;cohort;Coupled;design;Development;Development Plans;Doctor of Philosophy;doctoral student;Educational process of instructing;Educational workshop;Effectiveness;empowerment;Enrollment;Evaluation;Future;Generations;Goals;graduate student;hands-on learning;improved;Individual;innovation;Institution;Instruction;instructor;Learning;Learning Module;Learning Skill;Life;Marketing;Measurable;Mentors;minority trainee;Myers Briggs Type Indicator;outreach;Participant;peer;peer coaching;Population;Productivity;Program Accessibility;Program Sustainability;programs;Qualitative Evaluations;Quantitative Evaluations;Relationship-Building;Research;Rewards;Role playing therapy;Schools;Science;Self Assessment;skill acquisition;skills;skills training;Students;success;Support System;Testing;Time;Training;Training Activity;Training Programs;Transferable Skills;Underrepresented Minority;Underrepresented Students;United States

PROJECT_TITLE: Short Course In Transferable Skills Training (SHIFT) Program


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative This project seeks to understand the potential and mechanisms of germline mutagenesis induced at meiotic DNA double-strand breaks. Double-strand breaks are introduced genome wide during meiosis to initiate recombination between chromosome homologs in preparation for the reductional division to give rise to haploid gametes, but they are also known to be genome destabilizing lesions in somatic cells. Following up on our recent discoveries of germline deletions and duplications at meiotic breaks, this project pursues aims to understand the mechanisms that give rise to these events, the range of events at meiotic breaks, and the effect of age.

PI_NAMEs: JASIN, MARIA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Adolescent;Affect;age effect;aged;Architecture;ataxia telangiectasia mutated protein;base;Binding;Binding Sites;Biological Assay;Cell division;Cells;Chromosomal translocation;Chromosomes;Circular DNA;Detection;Development;Distant;DNA;DNA Double Strand Break;DNA Sequence Rearrangement;egg;Ensure;Event;Evolution;Excision;experience;experimental study;Frequencies;Generations;Genes;Genetic Recombination;Genome;genome-wide;Genomic Segment;Germ Cells;Germ Lines;Haploidy;Health;Homologous Gene;homologous recombination;Human;in vivo;Lesion;male;Maps;Meiosis;Meiotic Recombination;Mitotic;Mus;Mutagenesis;Mutant Strains Mice;Mutation;Nonhomologous DNA End Joining;Outcome;Paternal Age;Preparation;Prevalence;Publishing;Regulation;repaired;Resected;Risk;Role;segregation;Single-Stranded DNA;Somatic Cell;sperm cell;Spermatogenesis;SPO11 gene;Spo11 protein;transmission process;Yeasts;young adult

PROJECT_TITLE: Germline mutagenesis at meiotic double-strand breaks

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a 5-year survival rate ~10% and is predicted to become the second deadliest cancer within the next 10 years. Epigenetic changes regulating gene expression have become a focus of intense research to help in the development of new treatment for this dismal condition. This proposal will investigate the role of nuclear myosins in chromatin organization leading epigenetic silencing of gene expression during PDAC transformation.

PI_NAMEs: PEASE, DAVID R (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Binding;Biochemical;Biological;Cancer Biology;Cell membrane;cellular imaging;ChIP-seq;Chromatin;conditional mutant;Confocal Microscopy;Data;Development;Disease;DNA Sequence Alteration;Down-Regulation;druggable target;effective therapy;Enhancers;Epigenetic Process;epigenetic silencing;epigenomics;Event;experimental study;Foundations;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Engineering;Genome;Goals;Golgi Apparatus;Growth;Growth and Development function;Heterochromatin;immunocytochemistry;in vitro Model;in vivo;insight;Investigation;knock-down;KRAS oncogenesis;KRAS2 gene;Lamin Type A;Lead;Lesion;live cell imaging;loss of function;Lysine;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Mutation;Myosin ATPase;neoplastic;novel;Nuclear;Nuclear Lamina;Oncogenes;Oncogenic;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Peptide Initiation Factors;Phase;Play;Positioning Attribute;Postdoctoral Fellow;Process;programs;protein protein interaction;Proteins;Regulation;Research;Role;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Survival Rate;Testing;therapeutic target;Time;Training;Transcriptional Regulation;transcriptome sequencing;transcriptomics;tumor;Walking

PROJECT_TITLE: Mechanisms of gene expression regulation in pancreatic cancer


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Alcohol-associated liver disease (ALD) is a major public health problem in the United States. This application examines the mechanisms by which the neutrophils mediate the pathogenesis of alcohol- induced liver injury. Understanding the mechanism linking neutrophils to ALD pathogenesis is of importance; this will pave a way for the discovery of potential targeted therapy for patients with ALD.

PI_NAMEs: MA, JING  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Address;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Animal Model;Automobile Driving;Basic Science;Bilirubin;Binding;Biogenesis;Cell Communication;cell injury;Cell model;Cells;Cellular Stress;Clinical;Complex;Data;Disease;Docking;end stage liver disease;Ethanol;experimental study;extracellular;extracellular vesicles;Generations;Genes;Hepatic;Hepatitis;Hepatocyte;hepatocyte injury;Homeostasis;Immune;improved;Inflammasome;Inflammation Mediators;Inflammatory Response;intercellular communication;interpatient variability;intrahepatic;Knock-out;Knowledge;Link;Liver;Liver diseases;liver injury;MAP Kinase Gene;Mediating;Medical;Membrane;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;Multienzyme Complexes;Mus;Myeloid Cells;NADP;nanoscale;neutrophil;Neutrophil Infiltration;Oxidases;Oxidative Stress;Oxidative Stress Induction;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Patients;Pattern;Phagocytes;Phenotype;Phosphotransferases;Play;Production;Proteins;Public Health;Reactive Oxygen Species;Research Activity;Role;Serum;Severity of illness;Signal Pathway;systemic inflammatory response;targeted treatment;tissue injury;transcriptome sequencing;Translational Research;United States;Up-Regulation;vesicular release

PROJECT_TITLE: Mechanism of neutrophilic NCF1 in alcohol-associated liver disease pathogenesis

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE The goal of this proposal is to make available to scientists a uniquely powerful 7 Tesla brain MRI scanner, located at UC Berkeley, which achieves unprecedented spatial resolution in human brain research. We will create infrastructure to allow broad and efficient use of this scanner, by enabling in-person and remote access for international teams of neuroscientists, physicists, engineers, and clinicians to use the NexGen 7T MRI scanner. The proposed dissemination of the scanner will allow higher granularity in human neuroscience research with the capability of showing circuitry and neuronal activity at different cell layer depths in the neocortex.

PI_NAMEs: BECKETT, ALEXANDER ;FEINBERG, DAVID ALAN (contact);VU, AN T

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: 3-Dimensional;Acceleration;Alzheimer's Disease;Area;base;Brain;brain circuitry;Brain imaging;BRAIN initiative;brain magnetic resonance imaging;brain research;Cells;Collaborations;Communication;computer infrastructure;connectome;COVID-19 pandemic;Data;Data Analyses;data exchange;density;design;Development;Diffusion;Education and Outreach;Educational workshop;Engineering;Ensure;Epilepsy;experimental study;Feedback;Fingerprint;Functional Magnetic Resonance Imaging;Funding;Germany;Goals;Head;Human;Human Resources;Image;imaging approach;Imaging Techniques;improved;Infrastructure;innovation;Institution;instrument;International;Internet;Magnetic Resonance Imaging;Magnetism;meetings;Mental disorders;Neocortex;Nervous System Disorder;neural circuit;neuroimaging;neuronal circuitry;Neurons;Neurosciences;Neurosciences Research;next generation;novel;operation;outreach;Performance;Peripheral;Peripheral Nerve Stimulation;Persons;Physiologic pulse;Pilot Projects;prospective;recruit;Reproducibility;Research;Research Personnel;Resolution;Resources;RF coil;Scanning;Scientist;Signal Transduction;Speed;Structure;symposium;Synapses;System;Technology;temporal measurement;Testing;Time;tool;Training;transmission process;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination


NIH_SPENDING_CATS: Genetics;Kidney Disease;Pediatric

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: We anticipate that this study will generate novel insights into the mechanisms whereby the laminin binding integrins regulate kidney development and how mutations in these proteins result in fatal kidney diseases in humans. This knowledge is fundamental to our understanding of how the renal tubules function in health and disease.

PI_NAMEs: ZENT, ROY  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adhesions;Affect;Binding;Binding Proteins;Binding Sites;Biochemistry;Birth;Cell Adhesion;Cell Cycle;Cell Cycle Progression;cell motility;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Classification;Collagen;Data;Defect;Development;Differentiation and Growth;dimer;Disease;DNA Damage;DNA Repair;Epithelial Cells;Extracellular Domain;Extracellular Matrix;Grant;Health;Human;human disease;infancy;Infant;Infant Mortality;innovation;insight;Integrin alpha3;Integrin alpha3beta1;Integrin Binding;Integrins;interest;Kidney;Kidney Diseases;kidney epithelial cell;Knockout Mice;Knowledge;Laboratories;Laminin;Laminin Receptor;Ligand Binding;Lung;lung development;malformation;Mammals;Mediating;Membrane;Mesenchyme;Metanephric Diverticulum;Microscopy;migration;Minor;Molecular;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;nephrogenesis;Nephrons;Normal Cell;novel;Organogenesis;Pathology;Patients;Phenotype;Phosphotransferases;Play;Point Mutation;Proliferating;Property;Proteins;receptor;receptor binding;Renal tubule structure;response;Role;S phase;Signal Transduction;Structure;Surface;Systems Development;Testing;tool;Tubular formation

PROJECT_TITLE: The Laminin Receptors in Kidney Disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Achieving Maternal Equity and Transforming Health through Implementation Science and Training (AMETHIST@Penn) The Achieving Maternal Equity and Transforming Health through Implementation Science and Training (AMETHIST@Penn) Hub will support the vision of the NIH IMPROVE initiative by providing consultation and technical assistance to Maternal Health Research Centers of Excellence and other IMPROVE investigators. The AMETHIST@Penn team will work closely with NIH staff and the Data Innovation and Coordinating Hub/Resource Center and will support equity-focused maternal health implementation research through five Cores: (1) Administration, Leadership, and Evaluation; (2) Equity, Community, and Stakeholder Engagement; (3) Design, Methods, and Analysis; (4) Policy, Dissemination, and Communication; and (5) Training and Capacity Building. AMETHIST@Penn will advise IMPROVE investigators in engaging diverse and sometimes marginalized communities; guide the process of implementation research including the selection of theories, models, frameworks, strategies, and outcomes; accelerate implementation skills development in emerging and established maternal health scientists; and advance knowledge about successfully conducting implementation research.

PI_NAMEs: HAMM, REBECCA FELDMAN;LANE-FALL, MEGHAN BROOKS (contact)

PROJECT_TERMS: Acceleration;Accountability;acute care;Address;advanced analytics;Advisory Committees;Affect;Behavioral;Birth;Black race;Caring;Centers of Research Excellence;Childbirth;Clinical;clinical care;clinical practice;Collaborations;Communication;Communities;community partners;Consultations;Country;Data;data integration;design;Discipline of obstetrics;Disparity;effective intervention;Equity;Evaluation;experience;falls;Funding;Future;future implementation;Goals;Health;health disparity populations;health economics;Hispanic;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Income;Indigenous;Inequity;innovation;insight;Institution;International;intersectionality;Knowledge;Latinx;Leadership;lens;Location;Maps;marginalized community;marginalized population;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Mentors;Methods;Minority Groups;Modeling;National Institute of Child Health and Human Development;next generation;Outcome;Patients;Pennsylvania;Perinatal Care;Persons;Policies;postpartum care;Pregnancy;Pregnancy Outcome;Prenatal care;Procedures;Process;programs;prospective;Public Health;Research;Research Methodology;Research Personnel;Research Support;Resources;Risk Factors;rural area;Scientist;Services;skill acquisition;skills;Source;Specialist;success;Testing;theories;Training;Training Programs;transgender;United States;United States National Institutes of Health;Universities;Vision;women's outcomes;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Emerging clinician-scientists need translational science training to translate evidence to practices and policies that are critical in improving population health. This K24 award will use the RE-AIM framework to examine the reach, effectiveness, adoption, implementation (fidelity and cost) and maintenance of drinking water promotion and access interventions in schools and childcare centers that are being examined as a childhood obesity prevention strategy through two large cluster-randomized trials. This award will: 1) generate new research that will help adapt and translate these interventions to community settings, 2) provide rich training experiences in translational patient-oriented research, and 3) enhance Dr. Patel’s career development in research, leadership, and mentoring.

PI_NAMEs: PATEL, ANISHA INDRAVADAN (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acculturation;Adoption;Affect;Age;Award;Biometry;Cardiometabolic Disease;cardiometabolism;career;career development;Child;Child Care;children of color;Clinical;clinical center;Clinical Investigator;Cluster randomized trial;Collaborations;Communities;community engaged research;community setting;Computer software;cost;Cost Effectiveness Analysis;Data;Development;Dietary Assessment;Disease;Disparity;Dissemination and Implementation;dissemination science;drinking water;economic evaluation;Education;Effectiveness;elementary school;Environment;ethnic disparity;Ethnic Origin;evidence base;experience;Faculty;Feedback;Fellowship;Fostering;Foundations;Funding;Future;Grant;Health;health organization;Health Policy;Health Services Research;Home;implementation intervention;implementation research;implementation science;implementation strategy;improved;Income;innovation;Institution;Intake;Intervention;Leadership;Learning;Los Angeles;Low income;Maintenance;Manuscripts;Maternal and Child Health;medical schools;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Minority Groups;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Nutrition Policy;Obesity;obesity in children;obesity prevention;Overweight;patient oriented research;pediatric department;pediatrician;Pediatrics;peer coaching;Policies;Policy Maker;Population;population health;prevent;Prevention strategy;programs;Public Health;Publishing;Race;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Research Institute;Research Personnel;Research Training;Residencies;Resources;Role;San Francisco;Schools;Science;Scientist;sex;skills;socioeconomic disparity;Statistical Data Interpretation;Students;Subgroup;sugar;sweetened beverage;therapy development;Time;Training;Training and Infrastructure;training opportunity;Training Programs;Translating;Translational Research;Translations;undergraduate student;Vision;Vocational Guidance;Water;Water consumption;Work

PROJECT_TITLE: Mentoring in Translational Research to Prevent Disparities in Childhood Obesity and Cardiometabolic Disease