ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

ORG_STATE: FL

PHR: Reports of adverse experiences in childhood are highly prevalent among US military personnel and Veterans. Chronic stress in early childhood alters the immune system and increases inflammation in response to challenges in adulthood. In this proposal, we will determine if chronic stress in early childhood is a risk factor for persistent symptoms after mild traumatic brain injury TBI. Although the majority of TBIs in US military personnel and Veterans are mild, and recovery occurs in most mild TBI patients after 1-2 weeks, a subset have persistent symptoms such as cognitive problems lasting for weeks to months. This proposal will determine if a history of chronic stress in early childhood limits the recovery trajectory after a TBI that occurs in adulthood. We will identify the underlying molecular mechanisms that are initiated by chronic childhood stress to result in worsened outcome after TBI. We will also test a therapeutic that will target these molecular mechanisms and determine if this therapeutic improves behavioral recovery in the chronic phase of TBI.

PI_NAMEs: ATKINS, COLEEN M. (contact)

PROJECT_TERMS: Acute;Adult;adverse childhood events;Adverse event;Animal Model;Animals;Anxiety;ARHGEF5 gene;Astrocytes;Behavior;Behavioral;Brain;Brain Injuries;brain tissue;CASP1 gene;Cells;Childhood;Chronic;Chronic Phase;Chronic stress;Cognitive;cohort;conditioned fear;Corticosterone;Corticotropin;cytokine;Data;depressive symptoms;Development;early childhood;early life exposure;early life stress;Exhibits;experience;Exposure to;Female;Flow Cytometry;fluid percussion injury;Goals;Health;hippocampal atrophy;Hippocampus;hypothalamic-pituitary-adrenal axis;IL18 gene;Immune;Immune system;Immunohistochemistry;Impaired cognition;Impairment;improved;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin Activation;Interleukin-1 beta;Knockout Mice;Learning;Life;Link;Long-Term Potentiation;Macrophage;male;maternal separation;Measures;Memory;Memory impairment;Mental Depression;Microglia;middle age;mild traumatic brain injury;Military Personnel;military service;military veteran;Modeling;Molecular;Molecular Target;Multiprotein Complexes;Mus;neurogenesis;Neurologic;neuron loss;Neurons;novel therapeutics;Outcome;Pathologic;Pathology;Pathway interactions;persistent symptom;Persons;Phase;Population;Post-Concussion Syndrome;Predisposing Factor;preference;prevent;Problem behavior;psychologic;pup;Rattus;Recording of previous events;Recovery;Reporting;response;restraint stress;Risk;Risk Factors;screening services;Series;service member;sham surgery;Signal Transduction;Sorting;Sprague-Dawley Rats;Stress;Stressful Event;Sucrose;Synapses;Synaptic plasticity;targeted treatment;TBI Patients;Testing;Therapeutic;TLR4 gene;Traumatic Brain Injury;Traumatic Brain Injury recovery;Veterans;water maze;young adult

PROJECT_TITLE: Risk Factors for Chronic Memory Problems after Traumatic Brain Injury

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Our previous work showed that high fat diets lead to abnormally high appetites. More recently, we have determined that western diets high in fat also decrease energy expenditure. Our proposed project plans to investigate the mechanism by which high fat diets decrease energy expenditure, and information from our studies may lead to new treatment approaches for obesity.

PI_NAMEs: CHEN, JIANDE ;WILEY, JOHN W (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Adult;Affect;Agonist;American;Bacteroides;Brain;Brain-Derived Neurotrophic Factor;Brown Fat;Cell Nucleus;Cell Wall;Chemicals;Chronic;Data;Desire for food;Developing Countries;Development;Eating;Energy Metabolism;Epidemic;Fatty acid glycerol esters;fecal transplantation;Feces;feeding;Firmicutes;FOS gene;Gene Expression;Gene Proteins;Germ-Free;gut dysbiosis;gut microbiome;gut microbiota;High Fat Diet;Homeostasis;Hyperphagia;Hypothalamic structure;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;in vivo;Ingestion;Insulin;Insulin Resistance;Knockout Mice;Lead;Leptin;Leptin resistance;lipoteichoic acid;Maps;Measurement;Measures;Mediating;microbiota;Microglia;mitochondrial uncoupling protein;Mus;Nerve;Neurons;novel;novel therapeutic intervention;Obesity;Phenotype;Pilot Projects;Prevalence;Process;Protein Secretion;receptor;Receptor Activation;Reducing diet;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Ribosomal RNA;Role;Signal Transduction;Signal Transduction Pathway;Structure of stellate ganglion;Sympathetic Ganglia;Synapses;System;Testing;Thermogenesis;TLR2 gene;TNF gene;total energy expenditure;Transplantation;western diet;Wild Type Mouse;Work

PROJECT_TITLE: High Fat Feeding Reduces Energy Expenditure in Brown Adipose Tissue

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative The most recent data shows there were 35,873 annual cases of reportable infectious diseases in Oklahoma and this does not include thousands of other hospital-associated and non- reportable infectious diseases in the state. There is critical need to advance research and develop a better understanding of infectious microbes and the host immune system. The goal of Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) Phase-1 COBRE is to provide the mentoring, resources, and infrastructure needed in Oklahoma to foster outstanding Junior Investigators pursuing research in these fields.

PI_NAMEs: BALLARD, JIMMY D. (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Area;Bacterial Infections;Bacterial Toxins;Biology;Biomedical Research;career;career development;Career Mobility;Cellular Immunity;Centers of Research Excellence;Cessation of life;cohort;Collaborations;collaborative environment;Communicable Diseases;Communities;Data;Discipline;Disease;Educational workshop;Elements;Ensure;Environment;Event;Eye Infections;Faculty;Fostering;Foundations;Funding;Future;Genetic;Goals;Gram-Positive Bacteria;Grant;gut colonization;Health;Health Sciences;Hospitals;Human;Immune response;Immune system;Immunity;Immunology;improved;Infection;Inflammation;Infrastructure;innovation;Institution;Laboratory Research;Life;Mentors;Microbe;microbial;Microbial Biofilms;Microbiology;microbiome;Mission;Modernization;Molecular;multidisciplinary;Necrotizing Enterocolitis;news;Oklahoma;outreach;pathogen;Pathogenesis;pathogenic fungus;Phase;Pilot Projects;Productivity;Program Sustainability;programs;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;Science;Scientist;Strategic Planning;Structure;success;symposium;Technology;Therapeutic;Training;transcriptome;Translating;United States National Institutes of Health;Universities;Work;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Biometry;Budgets;Centers of Research Excellence;Communication;Educational workshop;Elements;Ensure;Fostering;Goals;Grant;Growth;Immunity;Individual;meetings;Mentors;microbial;Monitor;multidisciplinary;Occupational activity of managing finances;Office of Administrative Management;Oklahoma;Pathogenesis;Phase;Pilot Projects;programs;Reporting;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;success;symposium;Time;United States National Institutes of Health;Vocational Guidance;Writing

PROJECT_TITLE: Oklahoma CMP&I Administrative Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The SLC6A1 gene, which encodes the GABA transporter GAT1, is implicated in a spectrum of neurodevelopmental disorders including epilepsy, autism, and intellectual disability, collectively named SLC6A1 syndrome. Although the cellular and circuit mechanisms by which SLC6A1 mutations cause SLC6A1 syndrome remain unknown, my preliminary data show state-dependent seizures in thalamocortical circuits in a novel mouse model of SLC6A1 syndrome. Here I will use electrophysiological and genetic tools to determine whether thalamic circuits are key regulators of epileptic seizures associated with SLC6A1 syndrome, with the aim to eventually aid the clinical management of network dysfunction in SLC6A1 syndrome.

PI_NAMEs: VOSKOBIYNYK, YULIYA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Astrocytes;Attention;autism spectrum disorder;Brain;brain control;Cell Nucleus;Cerebral cortex;Clinical Management;Cognitive;Data;Development;Developmental Delay Disorders;Dissection;effective therapy;Electroencephalography;Electrophysiology (science);Epilepsy;exome sequencing;experience;extracellular;Functional disorder;GABA transporter;GABA Transporter 1;gamma-Aminobutyric Acid;Generations;Genes;Genetic;Hippocampus;Human;In Vitro;in vivo;Intellectual functioning disability;Location;Locomotion;Mediating;Modeling;motor deficit;Motor disability;mouse model;Mus;Muscle Tonus;Mutant Strains Mice;Mutation;Names;network dysfunction;Neurodevelopmental Disorder;Neurons;novel;optogenetics;Outcome;Patients;Physiological Processes;Point Mutation;post stroke;postsynaptic;prevent;Property;receptor;response;Role;Seizures;Series;Sleep;Sleep disturbances;Slice;Structure;Synapses;Syndrome;Techniques;Testing;Thalamic structure;Therapeutic Effect;therapeutic target;Time;tool;Transgenic Mice;Traumatic Brain Injury;uptake;Variant;Work

PROJECT_TITLE: Deconstructing epileptic circuits in a mouse model of SLC6A1 syndrome

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Microbiome

PI_NAMEs: DYER, DAVID W (contact)

PROJECT_TERMS: Applications Grants;Area;Bioinformatics;Cells;Centers of Research Excellence;Consultations;Core Facility;Cytometry;Data;Data Analyses;data submission;Ensure;experience;Experimental Designs;Future;Gene Expression;Gene Expression Profiling;Genomics;Human Resources;Immunity;Infection;information gathering;Institution;instrument;Knowledge;Laboratories;Manuscripts;Methods;microbial;microbiome;microbiome research;Molecular Biology;next generation sequencing;Oklahoma;pathogen;Pathogenesis;Preparation;Process;Protocols documentation;Research;Research Personnel;response;RNA;Role;Sampling;System;Technology;tool;Training;transcriptome sequencing;transcriptomics;Universities

PROJECT_TITLE: Microbiome and Transcriptomics Core (MTC)


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

PI_NAMEs: CHAABAN, HALA  (contact)

PROJECT_TERMS: Acceleration;Animal Model;anti-microbial peptide;antimicrobial;Bacteria;Bacterial Translocation;beta-Defensins;Biological;biomarker discovery;Brain Hypoxia-Ischemia;Caring;Cesarean section;Cessation of life;claudin 3;Clinical;clinical care;clinical practice;clinically relevant;Colitis;Colon;commensal bacteria;Complex;Critical Care;Data;Defensins;Development;Disease;Emergency Situation;Enterocytes;Epithelium;Etiology;Exhibits;Exposure to;Extracellular Matrix;feeding;gastrointestinal;Gastrointestinal Diseases;Glucosamine;Glucuronic Acids;Glycosaminoglycans;Goals;Goblet Cells;Growth;Growth Factor;gut inflammation;gut microbiome;Histology;Human;Human Milk;Hyaluronan;Hypoxia;Immunity;Immunology;Impairment;improved;In Vitro;in vivo;Infant;Infant Care;Inflammation;Inflammatory Response;Intervention;intestinal barrier;intestinal epithelium;intestinal homeostasis;intestinal injury;intestinal maturation;Intestinal permeability;Intestines;Investigation;Lactoferrin;Large Intestine;Medical;microbial;microbiome;Modeling;Modification;Molecular Weight;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Multiple Organ Failure;Mus;Necrosis;Necrotizing Enterocolitis;neonatal period;nonhuman primate;novel;novel strategies;occludin;Oklahoma;Oligosaccharides;Oral;Oral Administration;Paneth Cells;Papio;Pathogenesis;Patient-Focused Outcomes;Play;prebiotics;pregnant;premature;Premature Infant;preterm newborn;Prevalence;prevent;Prevention strategy;Preventive therapy;protective effect;protective factors;Proteins;pup;Reporting;Reproducibility;Research;response;Risk;RNA analysis;Role;Sepsis;Severities;Small Intestines;Stains;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Therapeutic;Tight Junctions;Tissues;TLR4 gene;Translations

PROJECT_TITLE: Novel Strategies for Prevention of Necrotizing Enterocolitis


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Technological advances in histopathology imaging and computing have enabled the in-depth characterization of pathology tissues. The overarching goal of this proposal is to develop computational algorithms to analyze histopathology image data to study disease status and progression.

PI_NAMEs: XIAO, GUANGHUA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;Architecture;Bayesian Method;Biological;Biology;Biomedical Research;cancer type;cell assembly;Cell Communication;cell type;Cells;Classification;classification algorithm;Clinical;clinical application;clinical care;Clinical Pathology;Communicable Diseases;Communities;Complex;Computational algorithm;Computer Models;Computing Methodologies;Data;data integration;data modeling;deep learning algorithm;Diagnosis;digital;digital pathology;Disease;disease diagnosis;disease prognosis;Disease Progression;disorder risk;drug discovery;Evaluation;experience;Extracellular Matrix;Goals;graph neural network;Hematoxylin and Eosin Staining Method;Heterogeneity;Histologic;Histopathology;Image;Image Analysis;Imaging technology;improved;insight;Intuition;Liver diseases;Machine Learning;machine learning method;Malignant Neoplasms;Methods;Microscope;Modeling;Molecular;molecular pathology;Molecular Profiling;Morphology;multiple datasets;Network-based;novel;outcome prediction;particle;Pathologic;Pathologist;Pathology;pathology imaging;Patient Care;Patients;Pattern;Physics;predictive modeling;Procedures;Research;Resolution;Risk Assessment;Scanning;single cell genomics;Slide;software development;Spatial Distribution;Stains;Statistical Models;Structure;Technology;Texture;Tissue imaging;Tissues;tool;user friendly software;Visual;whole slide imaging

PROJECT_TITLE: Developing computational algorithms for histopathological image analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PI_NAMEs: ZENEWICZ, LAUREN A (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;3-Dimensional;Adult;Antibiotic Therapy;antimicrobial;Apoptosis;Apoptotic;Bacteria;Bacterial Infections;Biological Products;Biology;Cell Death;cell type;Cells;Chronic;chronic inflammatory disease;Clostridium difficile;Colitis;Colon;commensal bacteria;Communicable Diseases;Communities;Complement;cytokine;Data;Disease;dysbiosis;Epithelial Cells;Epithelium;Etiology;experimental study;Future;gastrointestinal;gastrointestinal epithelium;gastrointestinal infection;Gastrointestinal tract structure;Genes;Genetic;Goals;Goblet Cells;Guanosine Triphosphate Phosphohydrolases;Health;high risk;Hospitals;Immune;Immune response;Immunity;Immunobiology;In Vitro;in vivo;Individual;Infection;infectious disease treatment;Inflammation;Inflammatory Bowel Diseases;inflammatory milieu;inflammatory modulation;Inflammatory Response;interest;interleukin-22;intestinal epithelium;intestinal homeostasis;Intestines;Life;Link;Lymphocyte;Lymphocyte Activation;Maintenance;MAP Kinase Gene;Mediating;microbial;microbiome;microbiota;Modeling;Monomeric GTP-Binding Proteins;mouse model;Mucous Membrane;Mus;neutralizing antibody;Oklahoma;Organ;Organoids;Paneth Cells;pathogen;Pathogenesis;pathogenic bacteria;Pathology;patient subsets;Patients;pharmacologic;Play;Population;prevent;Process;Production;Productivity;programs;Proteins;Pseudomembranous Colitis;Recurrent disease;Regulation;Relapse;Reporter;response;Role;Severities;Signal Pathway;Signal Transduction;Small Interfering RNA;Source;STAT3 gene;stem cells;Therapeutic;therapeutic target;Tissues;Toxic effect;Toxin;Up-Regulation;Villus;Virulence Factors;Work

PROJECT_TITLE: Regulation of C. difficile infection by the cytokine interleukin-22 (IL-22)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases;Skin Cancer

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Melanoma is the most aggressive form of cancer, which is characterized by rapid spread from skin to vital organs such as liver, kidneys, heart and brain, and while it represents only about 4% of skin cancer cases, it accounts for 75% of all skin cancer deaths. A number of new therapies became available within past decade, however, a significant portion of patients don't respond to the treatments or develop resistance over time. The investigators and collaborators of this proposal identified an enzyme (GCDH), which is associated with these aggressive and resistant melanomas, as well as pancreatic cancers, and, when inhibited, promotes cancer cell death, which the team will exploit in the proposed work to identify and validate chemical compounds that inhibit GCDH and establish potential of the enzyme as novel promising therapeutic target for melanoma and pancreatic cancer.

PI_NAMEs: SERGIENKO, EDUARD A. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acyl-CoA dehydrogenase;analog;Apoptosis;Apoptotic;Binding;Biochemical;Biological Assay;Brain;cancer cell;Cell Death;Cell Line;Cell Survival;Cellular Assay;cellular targeting;Cessation of life;checkpoint therapy;Chemicals;Clinical;Data;Drug resistance;Enzyme Kinetics;Enzymes;expectation;Functional disorder;Future;Glutarates;Glutaryl-CoA dehydrogenase;Heart;Heterogeneity;inhibitor;Kidney;knock-down;Liver;Lysine;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;Melanoma;Melanoma Cell;Melanoma patient;Metabolism;Molecular;Molecular Target;Monitor;mortality;Normal Cell;novel;novel therapeutics;Organ;Oxidoreductase;pancreatic cancer cells;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Proteins;Reaction;Research Personnel;Resistance;Resistance development;scaffold;screening;Skin;Skin Cancer;small molecule;Specificity;targeted treatment;Therapeutic;therapeutic target;therapy resistant;Time;tool;Transketolase;Validation;Work

PROJECT_TITLE: Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: BROWN, KEVIN MICHAEL (contact)

PROJECT_TERMS: Acute;Amino Acids;analog;Auxins;Biotin;Cell Culture Techniques;Cell membrane;Cells;Chemicals;Chronic;Co-Immunoprecipitations;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;differential expression;Disease;drug development;Drug Targeting;Epitopes;experimental study;extracellular;Gene Expression;Genes;Genetic;Guanosine Triphosphate;Guanylate Cyclase;Human;Immunity;Infection;Infection prevention;insight;Invaded;Kinetics;knock-down;Label;Life;Liquid Chromatography;microbial;Modeling;Modernization;Motility;Oklahoma;Organism;Paralysed;Parasites;Pathogenesis;Peptides;Permeability;Pharmaceutical Preparations;Phenocopy;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphotransferases;Plasmodium;Proteins;Proteomics;Pyrimethamine;Stable Isotope Labeling;Sulfadiazine;tandem mass spectrometry;Testing;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcription factor;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Vaccines;Virulence

PROJECT_TITLE: Elucidation of TgPKG kinase substrates required for Toxoplasma motility


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Precision Medicine;Rehabilitation

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The ability of blind individuals to regain sight through medical interventions and to use compensatory/assistive technologies varies greatly and is hard to predict, in part due to changes in the blind brain that may prevent it from processing sight efficiently later in life. With our team’s expertise in assistive technologies, advanced neuroimaging techniques and mechanisms of brain plasticity, we will investigate individual differences across scales in the brains of blind individuals, revealing key insights into how the brain develops and matures across different individuals. We will explore how individual profiles of brain plasticity relate to compensatory abilities, aiming to enable personalized treatments from unique neurobehavioral fingerprints which will improve the success of sight restoration outcomes for millions of blind individuals.

PI_NAMEs: STRIEM-AMIT, ELLA RUTH (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Affect;Age;Animals;Behavioral;Biological Markers;blind;Blindness;Brain;Clinical;Cognitive;cognitive ability;cognitive task;cohort;critical period;dark rearing;Darkness;Data;deafness;deprivation;Development;Disease;early onset;environmental enrichment for laboratory animals;Equilibrium;experience;Exposure to;Eye diseases;Fingerprint;functional gain;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Goals;Hearing;Human;improved;Individual;Individual Differences;individualized medicine;insight;inter-individual variation;Intervention;Laboratory Animal Models;Language;Life;Life Experience;limb loss;Link;Logic;Magnetic Resonance Imaging;Maps;Measures;Medical;Memory;motor deficit;Nature;neural;Neuroanatomy;neurobehavioral;neurochemistry;neuroimaging;Neuronal Plasticity;Neurons;neuroregulation;Outcome;Participant;Pattern;personalized biomarkers;personalized medicine;Persons;Population;prevent;Procedures;Process;recruit;Rehabilitation therapy;Research;resilience;response;Rest;Risk;Role;Sampling;Self-Help Devices;Sensory;Sensory Aids;sensory cortex;sensory substitution;sight restoration;Signal Transduction;success;Techniques;Testing;theories;Time;Tissues;tool;Touch sensation;Treatment Efficacy;Vision;vision rehabilitation;Visual;Visual Cortex;visual deprivation;Visual impairment;visual plasticity;Visually Impaired Persons

PROJECT_TITLE: Variability of Brain Reorganization in Blindness

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Schizophrenia

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative: We propose to develop fully specified Bayesian models, novel adaptations of density regression and deep learning for the study of multi-modal neuroimaging data in the student of developmental disorders.

PI_NAMEs: CAFFO, BRIAN SCOTT (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Adoption;Affect;application programming interface;autism spectrum disorder;Bayesian Method;Bayesian Modeling;behavioral outcome;behavioral phenotyping;Biological Markers;biomarker discovery;Brain;Clinical;clinical predictors;cloud platform;Cognitive;Communities;Complex;Computer software;cost;Data;data framework;data modalities;Data Set;deep learning;deep neural network;density;Detection;developmental disease;Diffusion Magnetic Resonance Imaging;Dimensions;direct application;Disease;disease model;Disease Outcome;Dropout;Economic Burden;Elements;Family member;feature extraction;flexibility;Functional Magnetic Resonance Imaging;Goals;imaging modality;Impaired cognition;Individual;Infrastructure;interest;Intuition;Joints;Knowledge;Learning;Measures;Medical;Meta-Analysis;Methodology;Methods;Modality;model building;Modeling;motor impairment;multimodal neuroimaging;multimodality;network models;neural;neuroimaging;neuroimaging marker;Neurons;neuropsychiatric disorder;Neurosciences;non-invasive imaging;novel;Pathway Analysis;patient variability;Patients;Pattern;Performance;Persons;Procedures;Process;programs;Research;Rest;Schizophrenia;Selection Criteria;Services;Severities;Signal Transduction;socioeconomics;software development;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Structure;Students;System;Techniques;theories;Training;user-friendly;Weight;Work

PROJECT_TITLE: Statistical methods for structural and functional integration in multi-modal neuroimaging data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity is a global health problem that greatly increases the risk for developing hypertension. An important contributor to obesity-related hypertension is excessive sympathetic nervous system outflow to cardiovascular organs. This proposal will determine if the hormone angiotensin-(1-7) provides cardiovascular protection in obesity by engaging brain circuits to reduce sympathetic outflow and blood pressure. These studies will advance our understanding of brain mechanisms contributing to blood pressure elevations in obesity, as well as inform on the potential for targeting angiotensin-(1-7) in the treatment of obesity-related hypertension.

PI_NAMEs: ARNOLD, AMY CHRISTINE (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acute;angiotensin I (1-7);Animals;antagonist;Attenuated;Bathing;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Brain;Brain region;Cardiovascular system;Cells;Chronic;conditional knockout;Cyclic AMP;Data;Dependence;Dependovirus;diet-induced obesity;Electrophysiology (science);Enzymes;Epidemic;Exhibits;Female;gamma-Aminobutyric Acid;Gene Expression;Gene Modified;Genetic;genetic approach;global health;Glutamates;Green Fluorescent Proteins;High Fat Diet;Hormones;Hypertension;Hypothalamic structure;Immunohistochemistry;in vivo;insight;Kidney;Knockout Mice;Laboratories;Leptin;Link;male;Measures;melanocyte;Methods;Modeling;mouse model;Mus;Nerve;neural circuit;neurobiotin;Neurons;Neurotransmitters;novel;novel strategies;Obese Mice;Obesity;Obesity Related Hypertension;obesity treatment;Organ;paraventricular nucleus;patch clamp;Pathway interactions;Peripheral;pharmacologic;Phenotype;Physiological;prevent;Pro-Opiomelanocortin;Publishing;receptor;Renin-Angiotensin System;Reporter;Research;response;restoration;Risk;Second Messenger Systems;sex;Structure of nucleus infundibularis hypothalami;Sympathetic Nervous System;Synapses;Technology;Testing;Time;Transgenic Mice;vascular bed

PROJECT_TITLE: Angiotensin-(1-7) and Hypothalamic control of blood pressure

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Biosynthetic gene clusters that encode the production of aryl polyene (APE) virulence factors are widespread among Gram-negative human pathogens. This project aims to investigate unresolved questions regarding APE cell envelope localization and environmental conditions that control their expression, by linking molecular genetics analysis to biochemical function. Our research will yield APE biosynthesis inhibitors that will inform development of antivirulence strategies, and identify molecular tools that will enable functional studies in non- model bacteria.

PI_NAMEs: CLAESEN, JAN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;Anabolism;analog;Anti-Bacterial Agents;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Bacteroidetes;Biochemical;Biological Models;Biology;Carotenoids;cell envelope;Cell membrane;Cells;Cessation of life;Characteristics;combat;Communicable Diseases;Communities;Complex;Contracts;cost;Data;Dedications;Defense Mechanisms;Development;Drug Targeting;Enterobacter;Enzymes;Esterification;Excision;Family;forward genetics;Future;Gene Cluster;Genes;genetic analysis;genetic approach;Goals;Gram-Negative Bacteria;Healthcare;human pathogen;Immune;immune clearance;in silico;in vivo;Individual;Infection;inhibitor;insight;Link;liquid chromatography mass spectrometry;Mediating;Membrane;Molecular;Molecular Genetics;multi-drug resistant pathogen;mutant;new therapeutic target;novel;opportunistic pathogen;pathobiont;pathogen;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Pathway interactions;Persons;Phagocytes;Pharmaceutical Preparations;Polyenes;pressure;Prevention;Production;Proteobacteria;Reactive Oxygen Species;Regulation;Regulator Genes;Regulatory Pathway;Relaxation;Research;Research Personnel;Resistance;Resistance development;Running;Series;small molecule;Societies;Staphylococcus aureus;staphyloxanthin;Substrate Specificity;Testing;Therapeutic;tool;United States;Uropathogenic E. coli;Virulence;Virulence Factors

PROJECT_TITLE: Uncovering aryl polyene biology to identify new drug targets in Gram-negative bacterial pathogens

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: In the changing ecosystem, we are faced with the evolving challenges of healthcare needs and inability to treat many chronic conditions, thus requiring discoveries and healthcare management strategies to improve health- related quality of life and develop cures; which are disproportionately affected by the paucity of physician scientists. Utilizing the “cells to society” multidisciplinary team-science approach, we aim to engage a diverse pool of MD students in hands-on research training and mentorship. This “Summer of Mentoring and Research Training (SMART)”, is anticipated to fill the gap that exists in the availability of physician-scientists to address the evolving global health challenges through research, discovery and awareness.

PI_NAMEs: GUPTA, KALPNA  (contact);RHEE, CONNIE MEEYOUNG

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Administrator;California;career;career development;Caring;Cells;Competence;Development Plans;Educational Curriculum;Educational workshop;Ethics;flexibility;Foundations;Future;hands on research;Health;improved;Individual;innovation;Journals;Leadership;Medical;Medical Students;Medicine;Mentors;Morals;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Patients;Phase;Physicians;Process;programs;Publishing;Reproducibility;Research;Research Proposals;Research Training;responsible research conduct;Science;Scientist;Shoulder;Societies;student participation;Technology;Training;Training Programs;Universities

PROJECT_TITLE: Summer Mentoring and Research Training (SMART)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE/RELEVANCE STATEMENT Disorders of hemochorial placentation are a significant human health issue. There is a paucity of knowledge regarding the regulation of trophoblast stem cells, their differentiation into invasive/extravillous trophoblast cells that effectively invade into the uterus and restructure uterine spiral arteries and establish the uterine-placental interface. Experimental dissection of fundamental mechanisms underlying the derivation of the invasive/extravillous trophoblast cell lineage is a key to understanding the etiology of placentation-related diseases and a necessity for establishing appropriate and efficacious diagnostic and therapeutic strategies.

PI_NAMEs: SOARES, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Blood Vessels;Cell Differentiation process;Cell Lineage;Cells;Derivation procedure;Development;Diagnostic;Disease;Dissection;early pregnancy loss;Embryo;Ensure;EP300 gene;Etiology;Fetus;Functional disorder;gene regulatory network;Goals;Health;Hemochorial Placental Development;Human;Impairment;In Vitro;in vivo Model;innovation;Internet;Invaded;Knowledge;Mediating;Modification;Molecular;National Institute of Child Health and Human Development;Nutrient;Pathogenesis;Pathway interactions;Physiological;PIK3CG gene;Placenta;Placentation;Population;postnatal;Pregnancy;pregnancy disorder;Primates;Process;Proteins;Proto-Oncogene Proteins c-akt;Rattus;Regulation;Regulatory Pathway;Research;Rodent;Role;Signal Transduction;Site;Specimen;Spiral Artery of the Endometrium;Study models;TFAP2A gene;TFAP2C gene;Therapeutic;Trans-Activators;trophoblast;trophoblast stem cell;Uterus;Vascular remodeling;Villous

PROJECT_TITLE: Trophoblast Differentiation


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Persons with HIV (PWH) on antiretroviral therapy have a high risk for metabolic disease that contributes to poor health outcomes. Adipose tissue T cells regulate adipose tissue function and are frequently altered in PWH. We seek to understand the specific adipose tissue immune cell populations that may contribute to metabolic disease and investigate the role of viral reservoir in maintaining inflammation.

PI_NAMEs: BAILIN, SAMUEL STUART (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;antiretroviral therapy;Biopsy;Blood;Cardiometabolic Disease;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Clinical;Clinical Research;Clinical Trials Design;Collaborations;comorbidity;Complex;Computer Analysis;cytokine;Data;Deposition;Development;Development Plans;diabetic;differential expression;Disease;Enrollment;experience;factor A;Fibrosis;Flow Cytometry;Frequencies;Funding;General Population;Genetic Transcription;Glucose Intolerance;Health;high risk;HIV;HIV Infections;HIV Seronegativity;Immune;Immunology;Impairment;Individual;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Insulin Resistance;Integrase;Interferon Type II;Interferons;Knowledge;Lipids;Macrophage;Master of Science;Memory;Mentored Patient-Oriented Research Career Development Award;Metabolic;Metabolic Diseases;Metabolism;Morbidity - disease rate;mortality;multiple omics;Pattern;Persons;Phenotype;polarized cell;poor health outcome;Population;Positioning Attribute;preventive intervention;Protocols documentation;Rain;recruit;Regimen;Research;Research Personnel;response;Risk;Role;single cell technology;single-cell RNA sequencing;skills;Sorting;T cell response;T memory cell;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;Tissue Sample;Tissues;TNF gene;Training;Transferase;Translational Research;United States National Institutes of Health;Viral;Viral Antigens;Viral reservoir;Virus

PROJECT_TITLE: Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIV

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Conventional opioids (prescription and illicit) are being replaced by the herbal supplement kratom (Mitragyna speciosa) during pregnancies, and multiple clinical cases have been associated with serious withdrawal symptoms in newborns presumably due to in utero kratom exposure. There is an urgent need to mechanistically investigate if kratom intake during pregnancy results in neonatal abstinence syndrome (NAS) as an outcome. A combination of systemic pharmacokinetic and pharmacodynamic studies are proposed in this R21 proposal to identify risks (or benefits) of kratom use during pregnancy.

PI_NAMEs: SHARMA, ABHISHEAK  (contact);WILKERSON, JENNY

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Adrenergic Agents;Affect;Agonist;Alkaloids;Amniotic Fluid;Behavior;Behavioral;Behavioral Model;behavioral study;Belief;Biological;Biological Markers;Birth;blind;Brain;capsule;Case Study;Child;Clinical;clinical diagnosis;Clinical Treatment;Coffee;Consumption;Data;Development;developmental toxicity;Dose;Drug Kinetics;Excretory function;Exposure to;Family;Female of child bearing age;fetal;Fetal Development;Fetal Tissues;Fetus;FOS gene;Freeze Drying;Glial Fibrillary Acidic Protein;Guidelines;Herbal supplement;Hospitalization;Human;illicit opioid;Immunohistochemistry;in utero;in vivo;Infant;Ingestion;Intake;Learning;long term memory;manufacture;Measures;Medicine;Metabolism;Methods;Mitragyna;Modeling;Moods;Morphine;Mothers;mu opioid receptors;multidisciplinary;Naltrexone;Natural Products;Neonatal;Neonatal Abstinence Syndrome;neonatal human;neonate;Newborn Infant;offspring;Opiate Addiction;Opioid;Opioid agonist;opioid use;opioid withdrawal;Oral;Outcome;Oxycodone;Pain;pediatrician;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Phosphorylation;Placenta;Plants;Plasma;post pregnancy;pre-clinical;Pregnancy;pregnant;Pregnant Women;prenatal exposure;Preparation;prescription opioid;Prevalence;programs;Protocols documentation;Publishing;pup;Rattus;receptor;Recording of previous events;Reporting;Research Project Grants;Risk;Rubiaceae;sex;Societies;Southeastern Asia;Specialist;specific biomarkers;Tea;Teratogenic effects;Teratogens;Testing;Time;Training;Trees;Ultrasonics;United States;United States National Institutes of Health;Urine;vocalization;Withdrawal;Withdrawal Symptom;Woman;Work

PROJECT_TITLE: Kratom alkaloid exposure during pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Opioid and alcohol polysubstance co-use is common and worsens treatment outcomes. In rodents, the neuropeptide oxytocin reduces opioid and alcohol intake and/or seeking and is theorized to act through dopamine and glutamate regulation in the nucleus accumbens. The proposed experiments will explore the utility of oxytocin as an effective therapeutic for oxycodone+alcohol polysubstance use and investigate whether these effects are accompanied by alterations in dopamine and glutamate efflux in the nucleus accumbens.

PI_NAMEs: WILKINSON, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol use disorder;Alcohols;allostasis;Americas;Attenuated;Behavioral;Blood alcohol level measurement;Brain region;Chronic;Clinical;Clinical Trials;Cocaine;Data;Dopamine;Dose;Drug abuse;Drug Use Disorder;Economics;effective therapy;efficacy evaluation;experience;experimental study;Female;Glutamates;Goals;High Pressure Liquid Chromatography;Homeostasis;Hour;Human;illicit drug use;in vivo;Infusion procedures;insight;Intake;Intravenous;intravenous administration;Investigation;logarithm;male;Mediating;Microdialysis;Modeling;Neurobiology;Neuropeptides;novel;Nucleus Accumbens;Opioid;opioid epidemic;opioid use;opioid use disorder;Oral;Outcome;overdose death;Oxycodone;oxycodone seeking;Oxytocin;Pharmaceutical Preparations;pharmacologic;polysubstance use;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;prescription opioid;prevent;Publishing;Rattus;Regulation;Relapse;restoration;Rewards;Rodent;Role;Self Administration;sex;Sex Differences;System;Techniques;Testing;theories;Therapeutic;therapeutically effective;Time;Training;Treatment outcome;United States;Water;Work

PROJECT_TITLE: Oxytocin regulation of intravenous oxycodone demand: a role for nucleus accumbens


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Abnormal fetal growth affects ~15% of all babies and increases the risk for injuries at delivery and to develop obesity, diabetes, and cardiovascular disease in childhood and later in life. Altered placental function is believed to directly contribute to changes in fetal growth and to better understand the underlying causes of these conditions we will identify key mechanisms regulating placental function and how the placenta directly influences the insulin-secreting cells in the fetus. This research may help design novel treatments to alleviate abnormal fetal growth and its short and long-term adverse consequences.

PI_NAMEs: JANSSON, THOMAS  (contact);ROSARIO-JOSEPH, FREDRICK

PROJECT_TERMS: adiponectin;Adult;adverse outcome;Affect;Age;Amino Acids;Animal Model;Beta Cell;Blood;Blood flow;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cell Separation;Cells;Childhood;Circulation;Complex;Conditioned Culture Media;Data;design;Development;Diabetes Mellitus;differential expression;Disease;Duodenum;Electron Transport;Embryo;endocrine pancreas development;ex vivo respiration;exosome;Fatty Acids;fetal;Fetal Growth;Fetal Growth Retardation;Fetal Macrosomia;Fetus;Folic Acid;FRAP1 gene;Future;Gene Targeting;Gene Transfer Techniques;Glucose;Growth;Homeobox;Human;Hydrocortisone;Impairment;in utero;In Vitro;in vivo;Incubated;Individual;Infant;Infection;Injury;innovation;Insulin;insulin secretion;Insulin-Like Growth Factor I;islet;Islets of Langerhans;knock-down;Knockout Mice;Knowledge;Leucine;Life;Link;Mediating;Metabolic;Metabolic Diseases;Metabolism;MicroRNAs;Mitochondria;Molecular;mother nutrition;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Nutritional;Obesity;obesity prevention;offspring;Pancreas;pancreas development;perinatal complications;Phenotype;Placenta;Placental Insufficiency;Pregnancy;Pregnancy Complications;programs;Proliferating;protein expression;reduced uteroplacental blood flow;Regulation;Reporting;Research;Respiration;Risk;Role;Signal Transduction;transcription factor;transcriptome sequencing;Transgenic Mice;Transposase;trophoblast;Umbilical vein;Woman;Work

PROJECT_TITLE: Trophoblast mTOR: a critical hub linking maternal nutrient supply to placental function, fetal growth and fetal islet function


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Human mobility underlies infectious disease transmission and determines the spatial and temporal dynamics of outbreaks and endemic disease dynamics. Yet, we do not understand how best to incorporate individual or population mobility patterns into models of infectious diseases. Here, we propose to perform the first systematic analysis of existing mobility data and models to identify which models perform best in specific circumstances using a range of simulations and data from historic outbreaks.

PI_NAMEs: CUMMINGS, DEREK A;WESOLOWSKI, AMY  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Africa;Age;Communicable Diseases;Communities;Contact Tracing;Country;COVID-19;COVID-19 pandemic;Data;Data Collection;data modeling;Data Set;Data Sources;Dengue;Dimensions;Disease;Disease Outbreaks;disease transmission;Ebola;Effectiveness;Endemic Diseases;Epidemic;epidemiologic data;Epidemiology;flexibility;Foundations;Frequencies;future outbreak;Genetic;Health Policy;Household;Human;human model;improved;Incidence;Income;Individual;individual variation;Infection;infectious disease model;Intervention;Investigation;life history;low and middle-income countries;Malaria;Mathematics;Methodology;Methods;Modeling;Molecular;Monitor;Movement;multiple datasets;novel;pandemic influenza;pathogen;Pathway interactions;Pattern;performance tests;Population;Population Study;Process;Property;Public Health;public health intervention;Research;Research Project Grants;Resources;response;Route;Rural;simulation;sociodemographics;Source;Standardization;Statistical Methods;Structure;Testing;Thailand;Time;transmission process;Travel;urban area;Validation;Variant;Work;ZIKA

PROJECT_TITLE: Human mobility models to forecast disease dynamics and the effectiveness of public health interventions

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: PROJECT NARRATIVE High-throughput RNA-Seq data collected under multiple conditions (e.g., tissues, experimental conditions, time points) from the same set of subjects provide an ideal resource for studying gene function and regulation. We propose to develop novel statistical methods and computational tools to maximize the utilization of these data and provide critical new insights into human genomics and its relation to public health.

PI_NAMEs: LI, GEN  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;analytical method;Autopsy;Biological Process;Collaborations;Communities;Complex;Computer software;computerized tools;cost;Data;data imputation;data integration;design;dimension reduction;Disease;Dose;Encyclopedias;Ensure;Exposure to;Family;flexibility;Funding;Gene Cluster;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic signature;genetic variant;genome database;Genotype;Genotype-Tissue Expression Project;Goals;Health;High-Throughput RNA Sequencing;human genomics;Image;improved;innovation;insight;keratinocyte;Maps;Measures;member;Methods;Modeling;multiple omics;novel;Ontology;Performance;Play;Public Health;Quantitative Trait Loci;Radiation;Radiation Dose Unit;Regulation;Research;Resources;response;Role;Sampling;Skin;Skin Cancer;Skin Tissue;Source;Specificity;Statistical Methods;Structure;Techniques;theories;Time;Tissue Sample;Tissues;tool;trait;transcriptome sequencing;ultraviolet;Ultraviolet Rays;United States National Institutes of Health;Validation

PROJECT_TITLE: Tensor Array Methods for RNA-Seq Analysis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed study will establish the feasibility and acceptability of a novel tailored, dyadic, resiliency intervention, “Resilient Families (R-FAM).” R-FAM aims to improve emotional distress and couple functioning in parents with babies in Neonatal Intensive Care Units (NICU)—who are at increased risk (30-50%) for acute and chronic distress. R-FAM has the potential to enhance family adjustment, child development, and ultimately inform a new and improved standard of care in NICUs across the world.

PI_NAMEs: GRUNBERG, VICTORIA ANN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Admission activity;Anxiety;arm;Awareness;Benchmarking;Birth;burnout;career;career development;Caregivers;Child;Child Development;Child Health;Child Rearing;Childbirth;Chronic;Clinical;clinical care;Clinical Investigator;Cognitive;Collaborations;Communication;Complex;coping;cost outcomes;Couples;Cultural Backgrounds;cultural health;Development;Distress;Education;effectiveness trial;emotional distress;emotional experience;Emotions;Enrollment;Ensure;Environment;Event;experience;Family;family management;Family Relationship;Fathers;feasibility testing;Focus Groups;follow up assessment;Fright;Funding;Future;Goals;Health;Healthcare;High-Risk Pregnancy;Home;Hospital Costs;hospital utilization;Hospitalization;Hybrids;Impairment;implementation trial;improved;improved outcome;Individual;innovation;Institution;Intervention;Interview;Life;Link;Maternal Health;Medical;medical schools;Medicine;meetings;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mid-career faculty;mindfulness;Modeling;Morbidity - disease rate;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonatal health;Neonatal Intensive Care;Neonatal Intensive Care Units;neonatal period;Newborn Infant;novel;Nurses;Outcome;Pamphlets;Parent-Child Relations;parental role;parenting intervention;Parents;Patients;Perinatal;Physicians;post-traumatic stress;prevent;Prognosis;programs;promote resilience;Psychologist;psychosocial;Psychosocial Assessment and Care;Publications;Qualitative Methods;randomized, clinical trials;reproductive;Research;Research Design;Research Personnel;resilience;Resources;Risk;Same-sex;satisfaction;Self Efficacy;Single Parent;Single-Parent Family;skills;social;Social support;Social Workers;standard of care;Strategic Planning;Stress;stress management;Structure;success;Surgeon;Testing;theories;therapy design;Time;Training;Training Programs;Transact;Trauma;treatment as usual;Uncertainty;United States National Institutes of Health;virtual;virtual delivery;Woman;Work

PROJECT_TITLE: Resilient Families (R-FAM): A dyadic resiliency intervention for parents of babies in neonatal intensive care

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research;Physical Activity;Prevention;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRTIVE Chronic pain is a leading cause of disability and major public health concern; thus, research aimed at improving our understanding of non-pharmacological approaches to pain management is crucial. Although individuals with chronic pain demonstrate interoceptive deficits, and mind-body therapies (MBTs) are purported to improve chronic pain conditions, limited research has directly examined interoception as a mechanism of change in MBTs. This predoctoral training and research project builds upon an existing program of research to study changes in interoceptive awareness as a mechanism of change in MBTs for chronic low back pain.

PI_NAMEs: GNALL, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: abuse liability;Address;Adult;Aftercare;American;Anxiety;Area;Attention;Awareness;Behavioral Medicine;Biometry;biopsychosocial;bodily sensation;career;Caring;Categories;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Trials;Collaborations;Complex;Connecticut;cost;daily functioning;Data;Development;disability;economic cost;Economics;Effectiveness;Emotional;Esthesia;exercise intervention;experience;Fellowship;Funding;Goals;Health;Healthcare;improved;Individual;Institution;Interoception;Intervention;Link;Measures;Mediation;Medical;Mental Depression;Mental Health;Mentorship;Methodology;Mind-Body Intervention;mind/body;multimodality;Musculoskeletal Pain;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;Pain;Pain interference;Pain management;Pain Measurement;pain outcome;pain patient;pain relief;pain sensitivity;Participant;Patient Self-Report;Patients;Perception;pharmacologic;Pharmacological Treatment;Physical activity;physical conditioning;pre-doctoral;Process;Productivity;programs;Property;Protocols documentation;psychologic;Psychological Factors;Public Health;Quality of life;Randomized, Controlled Trials;Research;Research Priority;Research Project Grants;Research Support;Resources;response;Role;Sensory;Severities;Sleep disturbances;social;societal costs;Testing;Training;training project;trial comparing;United States;Universities;Yoga

PROJECT_TITLE: Examining Interoceptive Awareness as a Mechanism of Change in Yoga for Chronic Low Back Pain


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The aim of this project is to understand changes in the brain underlying the emergence of social and emotional regulation during adolescence. Here, we will use cutting edge neurotechnologies coupled with carefully designed behavioral assessments to study changes in connectivity between the prefrontal cortex and the amygdala during adolescence. The findings from this study will impact our understanding of adolescent brain development and the early foundations of mental disease.

PI_NAMEs: GOTHARD, KATALIN M (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Amygdaloid structure;Anatomy;Anxiety;Area;Arizona;Arousal;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;China;Cognitive;cognitive development;cognitive process;cognitive skill;Coupled;Data;design;Development;Disease;Distant;early adolescence;emotion regulation;Emotional;emotional behavior;Equilibrium;experimental study;Feedback;Foundations;Functional Magnetic Resonance Imaging;Goals;Growth;Human;Image;Impulse Control Disorders;Impulsivity;in vivo;Individual;International;Lasers;Longitudinal Studies;Macaca;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Methods;millimeter;Monitor;Monkeys;multimodality;neural;Neurons;neurophysiology;neurotechnology;new technology;nonhuman primate;novel;Optics;Pattern;Physiologic pulse;Physiological;Prefrontal Cortex;Process;Psyche structure;Puberty;Regulation;Research;Resolution;response;Rewards;Risk;Risk Factors;Scientist;Site;skills;social;Social Behavior;social cognition;Social Development;social skills;Stimulus;Technology;Time;Universities;Virus;Vision

PROJECT_TITLE: Development of Amygdalo-Prefrontal Connections in Adolescent Macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-W(50)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: NARRATIVE Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), causes 1.6 million deaths per year globally, and thus there is an urgent need to develop new treatment approaches. Our proposed research is significant to public health because a better understanding of the host non-coding RNA landscape driving susceptibility to tuberculosis disease could lead to the development of better diagnostic biomarkers and adjunctive host- that seeks fundamental knowledge on the causes of pathogenicity that helps to reduce the burden of human diseases.

PI_NAMEs: GULER, RETO  (contact);HIDE, WINSTON ALEXANDER

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Africa;African;African ancestry;Antibiotic Therapy;antimicrobial;Antimycobacterial Agents;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Automobile Driving;Bioinformatics;Biology;Cessation of life;chronic infection;Code;cohort;Communicable Diseases;Data;design;Development;diagnostic biomarker;differential expression;Disease;Drug Targeting;Elements;Epigenetic Process;Gene Expression;gene interaction;Generations;Genes;Genetic;genetic architecture;Genetic Transcription;genetic variant;Genome;Genotype;Goals;Growth;Heritability;Heterogeneity;Host Defense;Host resistance;Human;human disease;Immune response;in silico;inter-individual variation;Investigation;knock-down;Knowledge;loss of function;Macrophage;MicroRNAs;monocyte;multidimensional data;Multidrug Resistance Induction;mycobacterial;Mycobacterium tuberculosis;novel;novel therapeutic intervention;Outcome;Partner in relationship;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;Predisposition;Public Health;Publishing;Quantitative Trait Loci;Research;resilience;Resources;response;RNA;Role;Sampling;Shapes;Site;South Africa;South African;Southern Africa;System;Systems Biology;targeted delivery;Techniques;Testing;Transcript;transcriptome;transcriptomics;treatment strategy;Tuberculosis;tuberculosis treatment;Uganda;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Targeting non-coding RNAs as host-directed drug therapy for tuberculosis

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Many patients with temporal lobe epilepsy have repeated spontaneous seizures that cannot be controlled with existing drug therapies. Epileptic circuit activity is characterized by excessive production of electrical signals at a specialized part of brain cells called the axon initial segment that is innervated by a unique but poorly understood regulatory interneuron. In this project, we will leverage recent technical breakthroughs to determine mechanisms underlying alterations in the ability of these interneurons to control abnormal electrical activity patterns in chronic temporal lobe epilepsy and evaluate the efficacy of closed-loop interventions directed at these cells for seizure control and amelioration of cognitive deficits.

PI_NAMEs: LOSONCZY, ATTILA ;SOLTESZ, IVAN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Action Potentials;Address;Adult;Anatomy;anti-epileptic agents;Area;Axon;Behavioral;behavioral outcome;brain cell;Calcium;Cell model;cell type;Cells;Chronic;Cognitive;Cognitive deficits;comorbidity;Computer Models;Coupling;Dedications;Development;efficacy evaluation;Electroencephalography;Electron Microscopy;Electrophysiology (science);Epilepsy;Functional Imaging;Future;gamma-Aminobutyric Acid;Gap Junctions;Generations;Hippocampus;Human;Hyperactivity;Image;Imaging Techniques;Impairment;In Vitro;in vivo;in vivo calcium imaging;Interneurons;Intervention;kainate;Kinetics;Knowledge;Label;Mediating;Membrane Potentials;Modeling;mouse model;Mus;novel;optogenetics;Outcome Measure;Pathologic;Patients;Pattern;Pharmacotherapy;Pilocarpine;Play;Population;Population Dynamics;Positioning Attribute;postsynaptic;Probability;Process;Production;Property;Pyramidal Cells;recruit;Refractory;Regulation;Resistance;Resolution;response;Rodent;Role;Seizures;side effect;Signal Transduction;Synapses;Synaptic Transmission;Techniques;Temporal Lobe Epilepsy;Testing;Therapeutic;Transgenic Organisms;treatment strategy;voltage

PROJECT_TITLE: Control of Axon Initial Segment in Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Diabetes increases the risk of cognitive impairment and dementia although the underlying mechanisms remain incompletely understood. We aim to evaluate newly developed, noninvasive measures of cerebral arterial compliance and blood flow in order to determine whether early functional brain changes proceed the development of irreversible cerebrovascular lesions and cognitive decline in older adults with diabetes and non-diabetic control participants. We will also examine the role of treatable/potentially modifiable mechanisms underlying cognitive changes, with the ultimate goals of advancing our understanding of the pathogenesis of diabetes-related cognitive dysfunction and identifying individuals at risk for cognitive impairment so that interventions to reduce dementia risk can be started as early as possible in order to improve health and functioning.

PI_NAMEs: BANGEN, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Affect;aged;Alzheimer's Disease;Alzheimer's disease pathology;Apolipoprotein E;arterial spin labeling;arterial stiffness;Autopsy;biomarker identification;Blood flow;Blood Pressure;Blood Vessels;blood-based biomarker;Brain;brain health;cardiometabolism;care providers;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular lesion;Cerebrum;clinical decision-making;Cognition;Cognitive;cognitive change;cognitive testing;comorbidity;Control Groups;Dementia;dementia risk;demographics;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;Disease Marker;Dose;early detection biomarkers;Early identification;executive function;Family member;Femur;follow-up;glycemic control;Glycosylated hemoglobin A;Goals;Health;Hemorrhage;Hypertension;Impaired cognition;improved;improved outcome;Individual;individualized medicine;interest;Intervention;Laboratories;Lesion;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Memory;Methods;mild cognitive impairment;neuroimaging;neuropathology;Neuropsychology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Participant;Peripheral;Physiologic pulse;Prevalence;Prognosis;Protocols documentation;Public Health;Resolution;response;Risk;Risk Factors;Risk Marker;Role;Sampling;Site;structural imaging;targeted treatment;Technology;Testing;treatment planning;Vascular Dementia;vascular risk factor;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Learning and performing complex skills requires careful control of motor variability. This proposal integrates innovative computational tools, optical imaging of neural activity and cutting-edge genetic techniques to determine how key neuromodulators act in the brain to control variability during complex skill learning.

PI_NAMEs: SCHREINER, DREW CLINTON (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Adenosine;Adolescent;Adult;autoencoder;Basal Ganglia;Behavior;Behavioral;bird song;Brain;brain control;BRAIN initiative;Calcium;cell type;circadian;Complex;Computational Technique;computerized tools;Corpus striatum structure;cost;Data;Disease;Dopamine;Finches;Genetic;genetic approach;Genetic Techniques;Goals;Health;Homologous Gene;Human;Image;Imaging Techniques;Impairment;improved;Individual;innovation;insight;interest;Learning;Learning Skill;Link;Mammals;Mediating;Mentors;Metabolic;Methods;Modeling;Molecular Genetics;Motor;motor control;motor learning;Movement;Mus;Music;neuroimaging;neuromechanism;Neuromodulator;Neurons;neuroregulation;Neurosciences;novel;optical imaging;Optical Methods;optical sensor;Optics;Pathway interactions;Pattern;Performance;Pharmaceutical Preparations;Psychological reinforcement;Purinergic P1 Receptors;receptor;Regulation;Research;Research Personnel;Role;sequence learning;Services;Signal Transduction;Signaling Molecule;Site;skills;Songbirds;Source;Speech;Supervision;syntax;System;Testing;Time;tool;Training;transcriptome sequencing;transmission process;tutoring;Variant;vocal learning;Wakefulness

PROJECT_TITLE: Beyond dopamine: dual neuromodulator regulation of motor variability and learning


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Childhood Injury;Congenital Structural Anomalies;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: RELEVANCE TO PUBLIC HEALTH Brachial plexus birth injury, the most common nerve injury in children, is a traumatic injury occurring at birth that causes muscle paralysis, abnormal growth of the shoulder bones, and lifelong impairment of arm function. Almost nothing is known about the timing and drivers of changes to bone from altered passive mechanical loading from short muscles, reduced functional loading, and direct nerve injury effects following brachial plexus injury occurring at birth. The proposed work will significantly advance understanding of how deformity develops and persists, and ultimately enable more effective and consistent treatments – addressing both muscle and bone – for brachial plexus birth injury and other perinatal neuromuscular injuries.

PI_NAMEs: COLE, JACQUELINE H;SAUL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Activities of Daily Living;Address;Affect;arm;arm function;Articular Range of Motion;Automobile Driving;Biological;biomechanical engineering;Birth;Birth trauma;bone;Bone Development;bone geometry;Bone Growth;Bone structure;Brachial plexus structure;Categories;Child;Childhood Injury;Clinical;clinical decision-making;Complex;Computer Models;Computer Simulation;Consensus;Contracts;Contracture;critical period;Deformity;Denervation;Deposition;Development;Diameter;Engineering;Environment;Family;FGF2 gene;Forearm;Foundations;Future;Growth;Growth and Development function;Growth Factor;humerus;Impairment;improved;Individual;Injury;innovation;Insulin-Like Growth Factor I;joint loading;Joints;Knowledge;Limb structure;Location;loss of function;mechanical load;Mechanics;Metabolism;Minerals;Modeling;multidisciplinary;Muscle;Muscle Development;muscular structure;Musculoskeletal;Natural regeneration;nerve damage;nerve injury;neural;Neuromechanics;neuromuscular;Operative Surgical Procedures;Orthopedic Surgery;Osteogenesis;Osteotomy;Outcome;Paralysed;Perinatal;postnatal;postnatal period;Posture;preference;Public Health;Quality of life;Radial;rapid growth;Rattus;reduced muscle mass;Reporting;Research;Research Design;Rodent Model;Role;scapula;Shoulder;Signal Transduction;skeletal;Stimulus;Structure;Surgical Disarticulation;timeline;Tissues;Traumatic injury;Weight-Bearing state;Work

PROJECT_TITLE: Development and Persistence of Tissue-Level Musculoskeletal Deformity Following Brachial Plexus Birth Injury

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE We have established several unique lines of mice that enable us to elucidate the important functions of low abundance cytoplasmic actins in normal and diseased skeletal muscle. Of greatest immediate relevance to public health, we propose experiments that will mechanistically explain the dramatic, but reversible muscle weakness in dystrophic muscle exposed to lengthening, or eccentric contractions. While protection from eccentric contractions is well accepted as proof-of-concept for new therapies to treat muscular dystrophies, the cause of weakness is poorly understood. We are proposing to elucidate the mechanisms through which each type of actin contributes to muscle cell maintenance to provide the foundation for therapy development.

PI_NAMEs: ERVASTI, JAMES M (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Acetylcysteine;Actins;Acute;Address;Animal Model;Antioxidants;Automobile Driving;Biochemical;Biological Assay;Buffers;Cardiac;Cell Maintenance;Cell membrane;chemoproteomics;Complex;Cysteine;Cytoplasm;Data;Defect;Drops;DYSF gene;Dystrophin;dystrophinopathy;experimental study;Exposure to;F-Actin;Foundations;Funding;Gene Modified;Genetic;Glycoproteins;Health;Human;imaging approach;Impairment;improved;Inherited;inhibitor;Injury;Knock-out;Link;live cell imaging;Maintenance;mdx mouse;Mediating;Membrane;Methodology;Methods;Mitochondria;Modification;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;Muscle function;Muscle Weakness;Muscular Dystrophies;mutant;Mutate;Myopathy;Natural regeneration;novel;novel therapeutics;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;pharmacologic;Phenotype;Physiological;polymerization;Polymers;prevent;Production;protein complex;Protein Isoforms;Proteins;Public Health;Publishing;Reactive Oxygen Species;Reagent;repaired;response;Role;Sarcolemma;seal;Site;skeletal;skeletal disorder;Skeletal Muscle;Source;Stress;Stretching;Striated Muscles;Structure;Testing;therapy development;wound;Xanthine Oxidase

PROJECT_TITLE: Costamere Defects in Muscular Dystrophies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  The project will identify the molecular and cellular underpinnings of magnetic susceptibility changes in AD. This knowledge will enable a biological link between MRI and neuropathology. If successful, it will facilitate the MRI characterization of the AD pathology and translate the knowledge to the clinical care of AD patients.

PI_NAMEs: GRINBERG, LEA TENENHOLZ;LIU, CHUNLEI  (contact);OTADUY, MARIA CONCEPCION GARCIA

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Affect;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid;Amyloid beta-Protein;amyloid imaging;Area;Autopsy;Biological;Biological Markers;Brain;Brain imaging;brain iron;Brain region;Characteristics;Clinical;clinical care;clinical imaging;Clinical Trials;Cognitive;cohort;cost;cost effective;Curiosities;Deposition;Diagnosis;diagnostic development;Disease Progression;Elderly;Etiology;Goals;healthy volunteer;High Prevalence;Histologic;Histology;Human;hyperphosphorylated tau;Image;imaging facilities;Imaging Techniques;Impaired cognition;improved;innovation;Intervention;Ionizing radiation;Iron;Knowledge;Label;life span;Link;locus ceruleus structure;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Methods;Molecular;mouse model;Names;Neurons;neuropathology;novel;Onset of illness;Pathologic;Pathology;Patients;Population;Positron;Positron-Emission Tomography;predict clinical outcome;Predisposition;Prefrontal Cortex;Probability;Property;protein aggregation;Proteins;putamen;Resolution;Scanning;Senile Plaques;Source;Specificity;Specimen;Staging;Standardization;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Techniques;Testing;Tissues;Tracer;Translating;Validation;Work;β-amyloid burden

PROJECT_TITLE: Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Although short-term exposures to ambient air pollutants and weather variables are independently associated with risk of suicide death, little is known about the effects of multi- environmental exposure mixtures on suicide. We will use our access to unprecedented data resources to quantify the combined effects of short-term ambient air pollutant and weather exposures on suicide death in the context of a person’s individual, familial and genetic characteristics. Results from this study may lead to the development of clinical, educational and/or pharmacological interventions for suicide, targeted at high-risk individuals.

PI_NAMEs: BAKIAN, AMANDA  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Air Pollutants;Air Pollution;ambient air pollution;Bayesian Modeling;case control;Cause of Death;Characteristics;Clinical;clinical development;Complex;Complex Mixtures;County;Cross-Over Studies;Data;data resource;design;DNA;Droughts;economic cost;Education;effective intervention;Environmental Exposure;Environmental Risk Factor;Etiology;Exposure to;Extended Family;Family;fine particles;Frequencies;Funding;gene environment interaction;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic Research;genetic variant;genome wide association study;Genomics;Goals;Heritability;Heterogeneity;high risk population;Individual;Inflammation;Knowledge;Life;Measures;Medical;Medical Examiners;Molecular;Nitrogen Dioxide;Ozone;Pathway interactions;Persons;pharmacologic;Population;Population Database;Positioning Attribute;Precipitation;Predisposition;Psychopathology;Records;Reporting;Research;Research Design;research study;Risk;Sampling;sex;Sodium Chloride;solar radiation;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Sunlight;Temperature;Testing;United States;Universities;Utah;Vulnerable Populations;Weather;weather variables;whole genome;Work

PROJECT_TITLE: The influence of multiple environmental exposures on suicide risk

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Gastrointestinal syndrome (GIS) is a disorder induced by anti-cancer radiotherapy and chemotherapy for which there is no effective treatment. Release of free heme upon either gastrointestinal (GI) bleeding or injury exacerbates colonic inflammation resulting in tissue damage. The work proposed here is designed to define the mechanisms by which free heme regulates gene expression during response to genotoxic and inflammatory stimuli as well as to assess therapeutic potential of hemopexin, a heme scavanger, in the GIS models.

PI_NAMEs: WEGIEL, BARBARA  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abnormal Epithelial Cell;Affect;anti-cancer;Antibiotics;Bacteria;Biliverdine;Binding;Biological;biological adaptation to stress;Biological Products;Biology;Biopsy;Body Weight;c-myc Genes;Catabolism;Cell Death;Cell Death Induction;Cell Therapy;Cells;Cessation of life;Chemotherapy and/or radiation;chromatin immunoprecipitation;Clinical;Colitis;Colon;Colon Injury;Colonic inflammation;complement C2a;Cytolysis;Data;Deferoxamine;design;dietary heme;Disease;DNA;DNA Damage;DNA Sequence;Doxorubicin;effective therapy;Enzymes;Epithelial Cell Proliferation;Epithelial Cells;Equilibrium;Erythrocytes;Excision;extracellular;Feces;G-Quartets;gastrointestinal;Gastrointestinal Hemorrhage;Gastrointestinal Injury;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome Stability;Genomic DNA;Genotoxic Stress;genotoxicity;gut inflammation;gut microbiota;H2AFX gene;healing;Heme;heme a;heme oxygenase-1;Hemoglobin;Hemolysis;Hemolysis Induction;Hemopexin;Hemorrhage;human tissue;Iatrogenesis;Immune;In Vitro;indexing;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Injury;intestinal barrier;Intestinal permeability;Intestines;Iron;irradiation;Ischemia;Ischemic Bowel Disease;Lead;Link;Macrophage;Measures;Mediating;Methods;microbiome analysis;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Myelogenous;Myeloid Cells;NF-kappa B;Normal tissue morphology;novel;Pathologic;Patients;Pattern;phenylhydrazine;Phosphorylation;Physiological;Population;Production;Proliferating;Proliferation Marker;promoter;protective effect;Radiation;Radiation therapy;Reactive Oxygen Species;Recombinants;reconstitution;response;RiboTag;RNA;Role;Scheme;Stains;Stimulus;Structure;Survival Rate;Symptoms;Syndrome;Therapeutic;tissue injury;Tissues;TLR4 gene;Toxic effect;transcriptome sequencing;translational potential;treatment strategy;Work

PROJECT_TITLE: Characterizing the role of the heme catabolism in tissue damage and inflammation.

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction is a major public health problem that is rising in prevalence with the aging population. By performing deep phenotyping of the patients from their Cardiac Magnetic Resonance images and Electronic Health Record simultaneously, we aim to provide phenotypic-specific, individualized treatment optimization based on the current massive amount of clinical data using deep learning.

PI_NAMEs: LI, QUANZHENG  (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: 3-Dimensional;aging population;Aortic Valve Stenosis;automated analysis;Big Data;Biological Markers;biomarker identification;Cardiac;cardiac magnetic resonance imaging;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;clinical decision support;clinical efficacy;clinical investigation;Clinical Trials;clinically significant;Code;Communities;comorbidity;Complex;Computer software;computerized data processing;Data;data imputation;deep learning;deep reinforcement learning;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Dimensions;Disease;Disparate;Economic Burden;effective therapy;EFRAC;electronic health information;Electronic Health Record;Environmental Risk Factor;Failure;feature extraction;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;heart imaging;Hospitalization;Hypertension;Image;Image Analysis;image processing;imaging biomarker;improved;individualized medicine;Knowledge;Laboratories;Learning;Life Style;lifestyle factors;longitudinal analysis;Machine Learning;Magnetic Resonance;magnetic resonance imaging biomarker;Malignant Neoplasms;Measurement;Methods;Modeling;Morbidity - disease rate;Morphology;mortality;multimodality;Nature;novel;novel therapeutics;Obesity Epidemic;open data;optimal treatments;Organ;Outcome;Patient imaging;Patients;Performance;personalized medicine;Pharmaceutical Preparations;Phenotype;Physicians;Pilot Projects;Population;preservation;Prevalence;Procedures;Prognosis;Psychological reinforcement;Public Health;Publishing;Quality of life;Radiology Specialty;Recommendation;reconstruction;Recording of previous events;recurrent neural network;Reporting;Research;Resources;risk stratification;Sepsis;Series;shape analysis;Source Code;Surface;symposium;Symptoms;Syndrome;targeted treatment;Techniques;Therapeutic;Treatment Efficacy;treatment optimization;treatment planning;treatment strategy;trend;Validation;Work

PROJECT_TITLE: Deep learning Based Phenotyping and Treatment Optimization for Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Crohn's disease is a chronic remitting and relapsing illness that results in intestinal inflammation, unwanted gastrointestinal symptoms and can lead to serious complications including surgery, hospitalizations, growth delays and poor quality of life. As there are limited treatment options approved for use in children and relapses are common, we will conduct a cluster-randomized clinical trial in children and young adults with moderate to severe Crohn's disease starting infliximab (anti-TNF). We will assess patient reported and disease modifying outcomes (endoscopic healing) between patients who received infliximab using an innovative, precision dosing strategy (treat-to-target) and those who received infliximab with the conventional dosing approach.

PI_NAMEs: MINAR, PHILLIP P (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 10 year old;17 year old;18 year old;adalimumab;Adrenal Cortex Hormones;Adverse event;Age of Onset;Antibodies;arm;Biological;Biological Markers;Biological Products;Caring;Child;Chronic;Chronic Disease;Clinical;clinical decision support;clinical remission;Clinical Trials;cohort;Computer software;conventional dosing;Crohn's disease;dashboard;Data;Development;Disease;Disease remission;Dose;drug clearance;Drug Exposure;Drug Kinetics;Drug Monitoring;Drug Targeting;Drug usage;early adolescence;Effectiveness;Enrollment;Exposure to;Flare;Fostering;gastrointestinal symptom;Goals;Growth;gut inflammation;healing;Hospitalization;Immunosuppressive Agents;improved;improved outcome;Incidence;Individual;infliximab;innovation;Intervention;Intestines;Kidney Transplantation;Label;learning progression;Leukocyte L1 Antigen Complex;Logistics;Maintenance;Maintenance Therapy;Measures;Modeling;Modification;Monitor;Monoclonal Antibodies;multidisciplinary;Natural History;neutrophil;North America;novel;novel therapeutics;Online Systems;Operative Surgical Procedures;Outcome;patient population;Patients;Pediatric Crohn's disease;peripheral blood;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Phase;Physicians;Population;pragmatic implementation;Prednisone;Publishing;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrent disease;Regimen;Relapse;Reporting;response;Risk;Serum;Severities;Statistical Computing;support tools;Symptoms;Testing;Therapeutic;TNF gene;treatment arm;Treatment Failure;United States Food and Drug Administration;Validation;young adult

PROJECT_TITLE: Precise Infliximab Exposure and Pharmacodynamic Control to Achieve Deep Remission in Pediatric Crohn's Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Natural killer (NK) cells are part of the immune system’s first line of defense, recognizing virus-infected or tumor cells and killing them to protect the host. Infection by coronaviruses (including SARS-CoV-2) may render the infected cell a target for killing by NKs, but the mechanism is largely unexplored given the focus on adaptive immunity to coronaviruses. Here, we will investigate a stress-induced signal for innate NK activation that we hypothesize is induced by coronavirus infection and may allow for recognition and killing of the infected cell.

PI_NAMEs: LEWANDROWSKI, MERCEDES  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Affect;Antibodies;antibody-dependent cell cytotoxicity;Antigens;betacoronavirus;Binding;Biological Assay;Biological Models;Blocking Antibodies;calreticulin;Cell Communication;cell killing;Cell Line;Cell surface;Cells;Cellular Stress;Coculture Techniques;Complex;Coronavirus;Coronavirus Infections;Data;Down-Regulation;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;experimental study;Flow Cytometry;Genes;genomic RNA;Golgi Apparatus;Human;human coronavirus;Immune system;Immunofluorescence Microscopy;In Vitro;Infection;Innate Immune System;killer inhibitory receptor;Knock-out;Life Cycle Stages;Ligands;Link;Literature;Lymphocyte;Major Histocompatibility Complex;Measures;Mediating;Membrane;Messenger RNA;Molecular Chaperones;Murine hepatitis virus;Natural Killer Cells;neoplastic cell;Nucleocapsid;Paper;Pathway interactions;Peptides;Phosphorylation;Production;Productivity;Proteins;Publications;receptor;Receptor Signaling;response;RNA Splicing;SARS-CoV-2 infection;senescence;Signal Induction;Stress;Surface;System;Testing;tumor;Up-Regulation;Viral;Viral Proteins;viral RNA;Viral Structural Proteins;Virion;Virulent;Virus;Virus Diseases;Virus Replication;Work;XBP1 gene;Zika Virus;ZIKV infection

PROJECT_TITLE: NK killing of coronavirus-infected cells


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative High-accuracy protein synthesis is a defining feature of the ribosome, ensuring that the encoded peptide sequences are faithfully generated. During the elongation phase of translation, the ribosome must move by a three-nucleotide increment; failure to do so results in frameshifting errors, leading to the accumulation of errant protein products that can aggregate and cause disease. This proposal is focused on understanding the mechanism by which the ribosome maintains its reading frame during stalling.

PI_NAMEs: ZAHER, HANI  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Alkylation;Amino Acids;Amino Acyl Transfer RNA;Binding;Biochemical;Biological;biophysical techniques;Cell Survival;Cells;Codon Nucleotides;Complex;computer studies;conflict resolution;Cryoelectron Microscopy;Data;density;Disease;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Elements;Ensure;Eukaryota;Event;experience;experimental study;Failure;fitness;genetic information;genetic resource;Genetic Transcription;Genomic Instability;Goals;Initiator Codon;insight;interdisciplinary approach;interest;Lead;Life;Maintenance;Mediating;Messenger RNA;Molecular Conformation;Movement;Nature;novel;Nucleotides;oxidation;Peptides;Phase;Polyribosomes;prevent;Prevention;Process;Property;protein aminoacid sequence;Protein Biosynthesis;Proteins;proteostasis;Quality Control;Reading;Reading Frames;Recovery;recruit;Regulation;Reporter;Reporting;Resolution;Resources;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA Sequences;Role;Starvation;Stress;Structure;Study models;Testing;Thinness;Time;Transcript;transcriptome;Transfer RNA;translation factor;Translation Initiation;Translations;Triplet Multiple Birth;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Reading frame maintenance by the ribosome during stalling

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: Pasadena

ORG_NAME: HUNTINGTON MEDICAL RESEARCH INSTITUTES

PHR: Narrative This research is relevant to public health because it will generate several new insights into the etiology and pathogenesis of serious neuropsychiatric diseases such as schizophrenia, autism spectrum disorders, epilepsy, obsessive compulsive disorder, mood and anxiety related disorders.

PI_NAMEs: VASUDEVAN, ANJU  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;angiogenesis;Anxiety;anxiety-related disorders;autism spectrum disorder;Behavior;Behavioral;Birth;Blood flow;Blood Vessels;Brain;Cells;Central Nervous System;Cerebral cortex;Cerebral endothelium;Cerebrovascular system;Communication;Complex;conditional knockout;Cues;Defect;design;Development;Disease;early embryonic stage;Electrophysiology (science);Embryo;Endothelial Cells;Endothelium;Epilepsy;Etiology;Event;GABA Receptor;GAD65 enzyme;GAD67 enzyme;gamma-Aminobutyric Acid;GAT3 transporter;Gene Expression;Gene Expression Profile;Genes;Goals;hindbrain;Impairment;in vivo;Individual;insight;loss of function;Mediating;Mental Depression;Mental disorders;Microcirculation;Midbrain structure;migration;Molds;Molecular;Moods;Mus;Neocortex;neocortical;Neurons;neuropsychiatric disorder;neuropsychiatry;neurotransmission;neurovascular;novel;Obsessive-Compulsive Disorder;Pathogenesis;Pathway interactions;Phase;Population;Positioning Attribute;postnatal;postnatal development;postnatal period;prenatal;Process;programs;Prosencephalon;Public Health;receptor;Regulation;repaired;Research;Role;Schizophrenia;Shapes;Signal Pathway;Signal Transduction;Time;Variant;vascular factor;Vascularization;Ventricular;vesicular GABA transporter;vessel regression;Work

PROJECT_TITLE: Novel Developmental Pathways Underlying Psychiatric Disorders


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Atrial fibrillation (AF), the most prevalence arrhythmia, is a public health burden. Atrial myopathy is a major underlying cause of AF. The precise molecular mechanisms underlying the evolution of AF-promoting atrial myopathy are complex and poorly understood. The proposed work will elucidate the causal role of cardiac fibroblast inflammasome signaling in the development of AF- promoting atrial myopathy.

PI_NAMEs: LI, NA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Action Potentials;Address;Affect;Anti-Inflammatory Agents;Area;Arrhythmia;Atrial Fibrillation;Attenuated;Automobile Driving;Cardiac;Cardiac Myocytes;Cells;Chronic;combat;Complex;Contractile Proteins;Coupling;Data;Development;efficacy evaluation;Evaluation;Evolution;Exhibits;Family;Fibroblasts;Fibrosis;Functional disorder;Genetic Transcription;Glucocorticoid Receptor;HCN4 gene;Heart Atrium;heart function;Histology;imaging study;Impairment;improved;Infarction;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukins;knock-down;Knock-in Mouse;Left;Left atrial structure;Macrophage;Maintenance;Maps;marenostrin;Mediating;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardium;Myopathy;NCOA3 gene;neutralizing antibody;novel;Nuclear;Optics;Outcome Study;Pacemakers;paracrine;patch clamp;Pathogenesis;Pathology;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;Phase;Phenocopy;Phenotype;Pilot Projects;Predisposition;Prevalence;prevent;Prevention;Profibrotic signal;Proteins;Public Health;Recombinant Interleukins;Resolution;response;Role;Sick Sinus Syndrome;Signal Transduction;Sinoatrial Node;Sinus;Testing;Therapeutic;transcription factor;Work

PROJECT_TITLE: Cardiac fibroblast inflammasome and atrial myopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Nanotechnology;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Recognizing the limitations associated with the conventional radiologic criteria for the selection of patients with hepatocellular carcinoma (HCC) for curative liver transplantation (LT), we aim to develop an integrated blood-based analysis using HCC circulating tumor cells (CTCs) for LT candidate selection. The long-term goal is to conduct exploratory development and prospective clinical studies of the proposed assays for phenotypic and molecular profiling of HCC CTCs.

PI_NAMEs: AGOPIAN, VATCHE  (contact);TSENG, HSIAN-RONG ;YOU, SUNGYONG

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Algorithms;Allografting;Behavior;biobank;Bioinformatics;Biological Assay;Biological Markers;Biology;Biometry;Biopsy;Blood;Blood Banks;Blood specimen;Cancer Etiology;candidate selection;Cell Separation;Cells;Cessation of life;Characteristics;Chemistry;Clinical;Clinical Research;Cryopreservation;curative treatments;detection assay;Development;Discrimination;Disease;Disulfides;Dropout;Eligibility Determination;Enrollment;Equilibrium;Evaluation;Expression Profiling;follow-up;Gene Expression;Genes;Genetic Transcription;Goals;high risk;immunocytochemistry;improved;in-vitro diagnostics;innovation;Institution;Joints;Liver;liver allograft;liver transplantation;Mediating;Messenger RNA;Microfabrication;Microfluidics;Modeling;Molecular;Molecular Profiling;Monitor;mortality;Names;nano;nano-string;nanomaterials;Nanotechnology;NanoVelcro;Neoplasm Circulating Cells;noninvasive diagnosis;Nonmetastatic;novel;novel strategies;Operative Surgical Procedures;Pathologic;Pathology;Patient Selection;Patients;Phenotype;Primary carcinoma of the liver cells;primary endpoint;prospective;Prospective Studies;Protocols documentation;PTPRC gene;Radiology Specialty;Recurrence;Research;Retrospective Studies;Risk;RNA;RNA marker;Sampling;Selection Criteria;Specificity;Stains;standard of care;statistics;Stratification;Testing;Time;transcriptomics;tumor;Tumor Biology;Tumor Markers;tumor progression;Unresectable;Vimentin;Waiting Lists

PROJECT_TITLE: Integrated analysis of HCC CTCs for Liver Transplant Candidate Selection

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE This project will investigate the neural circuits and mechanisms responsible for integrating the opposing drives of avoiding threats and seeking for rewards. Whereas exaggerated reward seeking is a hallmark of substance abuse and eating disorders, persistent avoidance is the most debilitating symptom of many fear-related disorders. Our ethologically-relevant paradigm combining natural threats with food cues will lead to a better understanding of how the brain computes threatening and rewarding information to generate distinct patterns of behavior.

PI_NAMEs: DO MONTE, FABRICIO HOFFMANN (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Adaptive Behaviors;Animals;Anterior;Area;Behavior;Behavioral;behavioral response;Brain;cell type;Cells;clinically relevant;conditioned fear;Conflict (Psychology);Corticotropin-Releasing Hormone;Cues;Data;debilitating symptom;Disease;Eating Disorders;Electrophysiology (science);Equilibrium;Experimental Models;experimental study;Exposure to;Food;Freezing;Fright;Genetic;genetic manipulation;Glutamates;Human;Hypothalamic structure;Immobilization;Immunohistochemistry;In Vitro;insight;Measures;motivated behavior;Nature;neural;neural circuit;neural correlate;neural network;neuromechanism;Neurons;Neuropeptides;Nucleus Accumbens;Odors;optogenetics;Pathway interactions;Pattern;photoactivation;Rattus;Regulation;response;Rewards;Risk;Risk Assessment;Rodent;Role;Signal Transduction;Slice;Specificity;Stimulus;Stress;Structure;Structure of paraventricular nucleus of thalamus;Substance abuse problem;Symptoms;Synapses;System;Testing;Tracer;transmission process;vocalization

PROJECT_TITLE: Neural Circuits Balancing Reward-Approaching with Threat-Avoidance

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]