NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: SANO CHEMICALS, INC

PHR: Project Narrative The proposal addresses the need for the development of a novel broad-spectrum antifungal for the treatment of resistant/recurrent oral and dermal candidiasis. We propose studies to demonstrate the effectiveness of a novel antifungal to treat resistant strains of Candida and to complete the formulation, stability, and toxicology studies required for an investigational new drug application.

PI_NAMEs: SMITH, JAMES LEIF (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acute;Address;analytical method;Animals;anti-fungal agents;Anti-Infective Agents;Area;Azoles;Bacteria;Benchmarking;Burkholderia;Candida albicans;Candidiasis;Caspofungin;Cell Death Induction;Cells;Chemicals;Clinical;Cutaneous;Data;Dermal;Development;Disease;Dose;Drug Formulations;Drug resistance;Effectiveness;efficacy evaluation;efficacy study;expectation;experience;Film;Fluconazole;Formulation;Fungal Drug Resistance;Fungal Peptides;fungicide;Gel;genotoxicity;Goals;In Vitro;in vivo;Induction of Apoptosis;Infection;Intravenous;Investigational Drugs;Investigational New Drug Application;Knowledge;Liquid substance;meetings;method development;Micronucleus Tests;Mucous Membrane;Mus;Mycoses;novel;novel therapeutics;Oral;Oral candidiasis;patient population;Periodicity;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;pre-clinical;preclinical development;Preparation;product development;Production;Property;Recurrence;recurrent infection;Research;Resistance;Resistant candida;response;Rodent;Safety;skills;Soil;Tablets;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Toxic effect;Toxicology;United States Food and Drug Administration;Vagina;vaginal candidiasis;Vulvovaginal Candidiasis;yeast infection;Yeasts

PROJECT_TITLE: Preclinical Development of Occidiofungin for Treatment of Oral and Dermal Candidiasis


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BIOPLATINUM TECHNOLOGIES, LLC

ORG_STATE: VA

PHR: Here, we will test the central hypothesis that platinum drugs devised to target and penetrate the tumor glycocalyx barrier will achieve enhanced levels of drug uptake in models of pancreatic cancer translating into enhanced clinical efficacy. These findings will address the two critical unmet needs in the treatment of pancreatic cancer to find 1) therapeutics to effectively treat drug resistant disease and 2) predictive biomarkers to identify which patients will benefit most from the available therapies.

PI_NAMEs: FARRELL, NICHOLAS PATRICK (contact);TREVINO, JOSE G.

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Active Biological Transport;adduct;advanced disease;Affinity;Aftercare;Anabolism;Antineoplastic Agents;Area;Biological Markers;Carbohydrates;Carboplatin;CD44 gene;Cell surface;Charge;Chemotherapy-Oncologic Procedure;Chondroitin Sulfate A;Cisplatin;Clinical;clinical efficacy;Clinical Oncology;Clinical Trials;commercialization;companion diagnostics;Companions;Complex;Data;Defect;Development;Diagnosis;Diffusion;Disease Resistance;Drug Delivery Systems;drug repurposing;Drug resistance;Drug Targeting;Drug Transport;Enzymes;Extracellular Matrix;Fluorouracil;Funding;Genomics;Glycocalyx;Glycosaminoglycans;Glypican;Goals;Health;improved;innovation;Intellectual Property;irinotecan;Isotope Labeling;Knowledge;Leucovorin;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Massey Cancer Center at the Virginia Commonwealth University;Mediating;meetings;Messenger RNA;MicroRNAs;Modeling;Modification;Mononuclear;Nature;neoplastic cell;new technology;overexpression;oxaliplatin;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;patient biomarkers;patient derived xenograft model;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacology and Toxicology;Phase;Platinum;Platinum Compounds;Polysaccharides;pre-clinical;precision medicine;predictive marker;Prognosis;Property;Proteins;Proteoglycan;Proteomics;Regimen;Research;Resistance;response;RNA;Role;safety study;Sampling;Small Business Technology Transfer Research;Stains;success;syndecan;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Tissue Microarray;Toxic effect;Translating;Treatment Failure;Treatment Protocols;treatment response;trend;tumor;uptake;Work

PROJECT_TITLE: Precision medicine for pancreatic cancer. Biomarker-guided drug delivery of platinum to tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SAN MATEO

ORG_NAME: CELLULAR VEHICLES INC.

ORG_STATE: CA

PHR: Project Narrative: Delivering cells directly into tissue (rather than into the circulatory system) remains a critical barrier in translating cell-based therapies to the clinic because cells in media cannot withstand the high pressures required for these injections. ‘Shear-thinning hydrogels’ are a class of compounds with structures well-suited to protecting cells during injection and helping them integrate into target tissues, but mixing cells into hydrogels is challenging and cannot be accomplished reproducibly by manual methods. Here, we propose to develop an automated mixing paradigm to prepare ‘cells in hydrogels’, which will create the fundamental building block for cell therapies that can target myriad solid-tissue diseases.

PI_NAMEs: JOSHI, NIKHIL  (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Address;Animal Model;Automation;Blood;Cardiovascular system;Catheters;Cell Density;cell preparation;Cell Survival;Cell Therapy;Cells;cellular imaging;Cessation of life;Characteristics;Clinic;Clinical;clinical application;clinical translation;clinically relevant;Color;confocal imaging;crosslink;curative treatments;Cytoprotection;density;design;Development;Diffusion;Disease;Dyes;Elements;Encapsulated;Engraftment;Ensure;Evaluation;experience;Extracellular Matrix;Formulation;Goals;Hand;Head;healing;Hyaluronic Acid;Hydrogels;Image Analysis;improved;Infusion procedures;Injectable;Injections;Injury;interstitial;Intravenous infusion procedures;leukemia/lymphoma;Liquid substance;Lung;Manuals;Measures;mechanical properties;Mechanics;Medicine;Methods;minimally invasive;Needles;novel;novel strategies;Organ;Outcome;Outcomes Research;Pathway interactions;Patients;personalized medicine;pharmacologic;Phase;Polymers;Positioning Attribute;Preclinical Testing;Preparation;preservation;pressure;Procedures;Process;Production;Property;Protocols documentation;quantitative imaging;Regenerative Medicine;Reproducibility;Safety;Site;Solid;Stains;standard of care;Standardization;Structure;success;Suspensions;Syringes;System;Techniques;Technology;Testing;therapeutic target;Thinness;three dimensional structure;Tissues;tool;Traction;Translating;Universities;Work

PROJECT_TITLE: Development of a novel tool for cell therapies that automates the formation and injection of cell-laden hydrogels directly into tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Morrisville

ORG_NAME: ASCENT BIO-NANO TECHNOLOGIES, INC.

ORG_STATE: NC

PHR: Project Narrative Automated liquid handling systems have revolutionized biomedical research laboratories by streamlining complex processes, enhancing precision, and enabling high-throughput experimentation. However, most existing systems require physical contact with solid structures in order to manipulate liquids, resulting in surface adsorption, cross-contamination, and limited programmability. The objective of the proposed SBIR project is to develop and commercialize an acoustic-based technology that overcomes these key obstacles and enables the manipulation and dispensing of liquid droplets in a rewritable, biocompatible, and high-throughput manner.

PI_NAMEs: WANG, LIN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Acoustics;Address;Adsorption;aqueous;Area;Automation;Automobile Driving;Benchmarking;biological systems;biomaterial compatibility;Biomedical Research;Blood;Cell Line;Cell Survival;commercialization;Complex;Computer software;design;Development;Devices;Diffusion;digital;Discipline;Disease;DNA sequencing;drug discovery;Drug Screening;electric field;Electronics;empowerment;Ensure;Event;experimental study;Face;Frequencies;Genetic;Genomics;high-throughput drug screening;improved;Industry Standard;invention;Laboratories;Laboratory Research;Liquid substance;Magnetism;Measures;meetings;microsystems;model organism;Monitor;nanobiotechnology;Organic solvent product;Performance;Pharmacologic Substance;Phase;Play;Preparation;pressure;Process;prototype;Reaction;Reagent;Reproducibility;Research;research and development;Research Personnel;Risk;Robotics;Role;Sampling;screening;Signal Transduction;Small Business Innovation Research Grant;Solid;Sputum;stem cell therapy;stem cells;stool sample;Structure;success;Surface;System;Systems Integration;Technology;Testing;Therapeutic;Time;tool;Transducers;Universities;Viscosity;voltage

PROJECT_TITLE: Development of the AcoustoDrop platform: an acoustofluidic-based, automated, liquid-handling system for manipulating and dispensing droplets in a rewritable, biocompatible, and high-throughput manner

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: LOUISVILLE

ORG_NAME: QUSPIN

ORG_STATE: CO

PHR: Project Narrative By making OPM-MEG technology widely accessible, this project has the potential to revolutionize functional neuroimaging and significantly contribute to the advancement of neurological disorder diagnosis and research on a global scale. This could improve the prognosis for millions of patients suffering from a wide range of neurological conditions.

PI_NAMEs: SHAH, VISHAL K (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TITLE: Commercialization Readiness of Wearable Optically Pumped Magnetoencephalography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Social Determinants of Health

ORG_CITY: El Cerrito

ORG_NAME: ELIMU INFORMATICS, INC.

PHR: Project Narrative This project will design and develop a shared decision-making software application for the treatment of asthma in adults. The application will request, prior to their visit with their doctor, information from patients about their preferences for treatment, the medications they are using for asthma, and how well-controlled is their asthma. During the visit, the application will combine this information with data from the patient’s medical records and show treatment options for this patient ffrom the national guidelines for treatment of asthma. The patient and the doctor can then make adjustments to the patient’s treatment plan that is based on guideline recommendations and the patient’s preferences. We will design this application together with patients and doctors. When our application prototype is ready, we will test its acceptance and usability by patients and doctors.

PI_NAMEs: BOXWALA, AZIZ A (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Address;Adoption;Adult;Adult asthma;Affect;Asthma;asthmatic patient;Automation;Awareness;Baptist Church;Caring;Client satisfaction;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;clinical encounter;clinical practice;clinical research site;Computer software;cost;Data;design;Development;Dissemination and Implementation;efficacy evaluation;electronic health data;Electronic Health Record;electronic health record system;Emergency department visit;Evaluation;Expedite Dissemination;experience;Fast Healthcare Interoperability Resources;flexibility;Focus Groups;Guidelines;Health;health disparity;implementation science;improved;Informatics;interoperability;Intervention;Logic;Michigan;Monitor;National Heart, Lung, and Blood Institute;Office Visits;Outcome;patient engagement;patient health information;Patient Preferences;Patients;Pharmaceutical Preparations;Phase;Physicians;Population;Positioning Attribute;preference;primary care clinician;prototype;Provider;provider adherence;Public Health;Publications;Quality of life;Recommendation;Sapphire;shared decision making;Site;social determinants;social health determinants;Specialist;Specific qualifier value;standard of care;support tools;Surveys;Testing;treatment guidelines;treatment planning;United States Agency for Healthcare Research and Quality;Universities;Update;usability;Visit;web site

PROJECT_TITLE: TIBSA: A tailored interoperable guideline-based clinical decision-support system for asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Since its inception, the Petri dish has been an irreplaceable tool for biomedical scientists. Recent advances in next-generation Petri dish technology have been incremental, and to date, a truly multifunctional, high- performance device that extends the capabilities of a Petri dish has yet to be realized. The objective of this proposed project is to develop and commercialize a multifunctional, smart Petri dish by leveraging new advancements in acoustic tweezer technology to enable versatile, precise, biocompatible cell/particle manipulation in a Petri dish.

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Adopted;Area;Automation;Automobile Driving;Axon;Biological;biomaterial compatibility;Biomedical Research;biomedical scientist;Cell Survival;Cells;Central Nervous System;Characteristics;Collagen Fiber;commercialization;Computer software;cost effectiveness;Cytolysis;Dendrites;design;Development;Devices;Diameter;Electronics;engineered stem cells;Ensure;exosome;experimental study;Extracellular Matrix;extracellular vesicles;fabrication;Feedback;Freedom;Human;improved;Individual;invention;Label;Laboratories;laser tweezer;Length;Magnetism;Manuals;Measures;meetings;Mesenchymal Stem Cells;meter;Microbiology;microsystems;Migration Assay;nano;nanobiotechnology;Nature;Nervous System;next generation;optic tweezer;Optics;particle;Pattern;Performance;Pharmacologic Substance;Phase;Positioning Attribute;Property;prototype;research and development;Research Personnel;Resolution;Robotics;Series;Shapes;Skeletal Muscle;Small Business Innovation Research Grant;Speed;submicron;success;surface coating;System;Systems Integration;Techniques;Technology;technology development;Testing;Tissue Engineering;Tissues;tool;Translating;Translations;Universities;Vascular System

PROJECT_TITLE: Development of an acoustic-based smart Petri dish for contact-free, precise, versatile bioparticle manipulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Pediatric

ORG_CITY: HILLSBORO

ORG_NAME: FINNEGAN THE DRAGON, INC

ORG_STATE: OR

PHR: PROJECT NARRATIVE Finnegan the Dragon has developed a speech-to-print preschool curricula and mobile gaming app to improve speech and early literacy skill development as well as mitigate the harmful effects of passive screen time for children ages 2-6. The research will test the usability and adoptability of the curricula and mobile gaming system in the classroom and home environments, and establish baseline efficacy data for the learning system use.

PI_NAMEs: CADIZ, EMILY JOHN (contact)

PROGRAM_OFFICER_NAME: PARSAFAR, PARISA

PROJECT_TERMS: Achievement;Address;Adopted;Age;Attention;Awareness;behavior observation;Benchmarking;Child;Clinical;commercial application;Consumption;Copyright;Data;design;Development;Diagnostic;E-learning;early childhood;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;English Language;Enrollment;Equity;experience;Family;Future;Goals;Growth;handheld equipment;Head Start Program;Home;Home environment;improved;Industry;innovation;Institution;Instruction;Intervention;intervention cost;invention;Knowledge;Language;Language Development;Laws;Learning;learning outcome;Legal patent;Letters;Life;literacy;Marketing;Measures;meetings;Methods;Mission;Motor Skills;Music;Music Therapy;Nature;Neurologic;Nursery Schools;Oregon;Outcome;Phase;phonological awareness;phonology;Play;Printing;Regulation;Research;School-Age Population;Schools;skill acquisition;skills;Small Business Innovation Research Grant;sound;Speech;Speech Development;Speech Recognition Software;statistics;Students;Support System;System;Target Populations;teacher;Technology;Testing;Time;Trademark;tv watching;United States;usability;Woman;Work

PROJECT_TITLE: Development of preschool speech-to-print curricula with online gaming technology for early language development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

ORG_CITY: Lowell

ORG_NAME: REVBIO, INC.

ORG_STATE: MA

PHR: Project Narrative In 2018 approximately 210,000 people in the U.S. underwent a craniotomy requiring cranial flap closure using hardware fixation devices (e.g., plate and screw systems). Clinical results are still plagued by loose or migrating plates, metallic imaging artifacts, devastating CSF leaks, and infections that often requires surgical intervention. The proposed human feasibility study to show the stand-alone use of a novel wet field bioresorbable bone adhesive, known as Tetranite® (“TN”), to fixate cranial bone flaps following brain surgery could significantly shift the way craniotomy procedures will be performed and will improve clinical outcome measures including enhanced bone healing, reduction in pain, and better cosmesis.

PI_NAMEs: HESS, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Address;Adhesives;Adverse event;Affect;Algorithmic Analysis;Algorithms;Anatomy;Animals;Appearance;Applications Grants;Atrophic;Biocompatible Materials;biomaterial compatibility;bone;Bone Cements;bone healing;brain surgery;Cadaver;calcification;Cephalic;Client satisfaction;Clinical;clinical outcome measures;Clinical Research;Clip;Cosmetics;cost;Craniotomy;cranium;density;design;Devices;electronic data capture system;Enrollment;FDA approved;Feasibility Studies;follow-up;Goals;healing;Hospitals;Human;human study;Image;improved;Industry;Infection;innovation;instrument;Left;Life;Magnetic Resonance Imaging;Maintenance;Measures;Mental Depression;metallicity;Methodology;migration;Morphologic artifacts;Necrosis;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;participant enrollment;Patient Care;Patient Outcomes Assessments;Patients;Performance;Persons;Phase;Pilot Projects;Positioning Attribute;preclinical development;preclinical study;primary endpoint;primary outcome;Probability;Procedures;Process;Property;Publishing;radiological imaging;Resistance;Safety;sample fixation;Sample Size;scaffold;Scalp structure;seal;sealant;secondary endpoint;secondary outcome;self esteem;Site;Skin;standard of care;Sterilization;success;System;Testing;Time;Tissues;Training;Translating;Vascularization;Woman;wound closure;X-Ray Computed Tomography

PROJECT_TITLE: A Pilot Clinical Study for a Novel Bioresorbable Bone Adhesive to Evidence Improved Cranial Flap Fixation Based on Radiographic Imaging and Patient Reported Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-A (11)]


ORG_CITY: BOSTON

ORG_NAME: TIGATX INC

PHR: Narrative TIGA-001 is being developed as a first-in-class, IgA-based monoclonal antibody immunotherapy treatment for advanced/metastatic EGFR-positive Non-small cell lung cancer (NSCLC), the leading cause of cancer death in the United States. TIGA-001 harnesses the cytotoxic potential neutrophils as novel effector cells to drive IgA- mediated antibody-dependent cellular cytotoxicity of EGFR-positive tumors, and has been designed to overcome several of the critical limitations of currently approved or investigated therapies. This project will progress towards the clinic as a promising therapy for NSCLC patients who are resistant to standard-of-care therapy, providing potential for significant improvement in patient survival and quality of life.

PI_NAMEs: STERN, HOWARD M (contact)

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: actionable mutation;Antibodies;antibody immunotherapy;Antibody Therapy;antibody-dependent cell cytotoxicity;assay development;Biological Assay;Biological Markers;biomarker identification;cancer cell;Cancer Etiology;Cancer Patient;Cancer Prognosis;cell bank;Cell Line;Cessation of life;Cetuximab;Clinic;Clinical;clinical development;Clinical Trials;clinically relevant;cross reactivity;cytokine;Cytolysis;cytotoxic;cytotoxicity;Data;design;Development;Dose;Drug Kinetics;Drug Utilization;Effector Cell;Engineering;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;expression vector;FDA approved;Feedback;first-in-human;Funding;Generations;Goals;Human;Immunoglobulin A;Immunoglobulin G;improved;improved outcome;In Vitro;in vivo;Investigational Drugs;Investigational New Drug Application;Lead;Legal patent;Malignant Neoplasms;manufacture;Mediating;meetings;Monoclonal Antibodies;mutant;neoplastic cell;neutrophil;Neutrophil Infiltration;next generation;Non-Small-Cell Lung Carcinoma;nonhuman primate;novel;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase;Positioning Attribute;predictive modeling;Production;programs;Protein Engineering;Protocols documentation;Quality of life;Research;research clinical testing;Resistance;resistance mechanism;response;Risk;Safety;safety assessment;safety study;Serum;Small Business Innovation Research Grant;Solid;Specimen;stable cell line;Stains;standard of care;Structure;Survival Rate;systemic toxicity;technology platform;Therapeutic;Toxicology;tumor;Tumor Antigens;Tyrosine Kinase Inhibitor;United States;vector

PROJECT_TITLE: Late-stage development and de-risking of a novel monoclonal antibody immunotherapy for EGFR-positive solid cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: PUBLIC HEALTH RELEVANCE/ PROJECT NARRATIVE High maternal mortality is a major public health problem in many settings. Because of low antenatal care (ANC) and skilled birth usage, Ugandan women and their children suffer from high maternal and perinatal mortality. We developed a promising intervention (Support-Moms app) that shares targeted health information, and engages social support networks through scheduled reminders to help support pregnant women to utilize maternity services in rural Uganda. We now propose to test and implement the Support- Moms intervention and hypothesize that Support-Moms will be feasible and cost-effective in improving utilization of available maternity care services, and ultimately reduce maternal and perinatal mortality.

PI_NAMEs: ATUKUNDA, ESTHER CATHYLN (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Adopted;Africa South of the Sahara;antenatal care;Anxiety;Appointment;arm;Behavioral;Birth;Birth Weight;care systems;Cessation of life;Child;Childbirth;Communication;Consolidated Framework for Implementation Research;coping;coping mechanism;cost;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness evaluation;cost-effectiveness ratio;Data;Death Rate;Decision Making;Effectiveness;effectiveness measure;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Eligibility Determination;empowerment;Enrollment;Environment;Evaluation;experience;fetal;Fostering;Friends;Future;Health;Health Benefit;Health care facility;Health Personnel;Health Policy;Health Services;Health Services Accessibility;Health system;implementation intervention;implementation outcomes;implementation strategy;improved;incremental cost;incremental cost-effectiveness;Individual;Infant;Institution;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Knowledge;Learning;Maternal Health;maternal morbidity;Maternal Mortality;Mental Depression;mHealth;mhealth interventions;Morbidity - disease rate;multidisciplinary;National Institute of Child Health and Human Development;Newborn Infant;Notification;obstetrical complication;Outcome;Participant;patient oriented;Perinatal;perinatal morbidity;Perinatal mortality demographics;perinatal outcomes;Pilot Projects;Positioning Attribute;post pregnancy;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prevent;primary outcome;Proctor framework;Public Health;public health relevance;Quality of life;Quality-Adjusted Life Years;Questionnaires;Randomized;Randomized, Controlled Trials;Readiness;Records;Research Personnel;Resource Allocation;Risk;routine care;Rural;scale up;Schedule;Scientist;secondary outcome;service utilization;Services;skills;social;social engagement;Social Network;Social support;standard of care;success;Taxonomy;Techniques;Telephone;Testing;Trust;Uganda;United States National Institutes of Health;uptake;Visit;Voice;Woman;Women's Health

PROJECT_TITLE: Integration of a patient-centered mobile health intervention (Support-Moms) into routine antenatal care to improve maternal health in Uganda

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BOWLING GREEN

ORG_NAME: BUMPTUP LABS, INC.

ORG_STATE: KY

PHR: PROJECT NARRATIVE Women are dying from pregnancy-related issues at higher rates in the U.S. than in any other developed nation in the world, and more than 50% of these deaths are linked to issues related to maternal weight (i.e. overweight/obesity). BumptUp® is the only mobile health app that provides pregnant and postpartum women with evidence-based exercise programming along with progress and symptom tracking, dietary recommendations, and social support. It is well-established that mobile health apps positively impact user lifestyle changes; thus, development of BumptUp® has great potential to reduce the large number of preventable maternal deaths in the U.S. while also reducing healthcare costs.

PI_NAMEs: TINIUS, RACHEL ANN (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 37 weeks gestation;Accelerometer;Address;Adoption;Age;Algorithms;American;American College of Obstetricians and Gynecologists;Birth;Black race;black women;blood glucose regulation;Blood Pressure;blood pressure reduction;Businesses;Cellular Phone;Cessation of life;child bearing;Chronic;clinical care;Clinical Trials;college;commercial application;commercialization;Control Groups;Dangerousness;Data;Death Rate;design;Developed Countries;Development;Diabetes Mellitus;dietary;Discipline of obstetrics;effective intervention;efficacy evaluation;Engineering;evidence base;Exercise;experience;Fatigue;Feedback;Female of child bearing age;Fetal health;Fetal Heart Rate;Focus Groups;Fright;gestational weight gain;Goals;Growth;Guidelines;Health;Health Care Costs;Health Personnel;healthy lifestyle;heart rate monitor;High-Risk Pregnancy;Hypertension;improved;improved outcome;Income;infant outcome;Insurance;Internet;Intervention;Interview;Life Style;Life Style Modification;Link;low socioeconomic status;Marketing;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;maternal weight;Measures;medical attention;Mental Health;Minority Women;Mission;mobile application;Mobile Health Application;mobile phone based intervention;mortality;Mothers;National Institute of Child Health and Human Development;Nausea;novel;Obesity;obstetric outcomes;Outcome;Overweight;Participant;Performance;Phase;Physical activity;Population;post pregnancy;postpartum care;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnancy related death;pregnant;Pregnant Women;prenatal;Prenatal care;Randomized Controlled Clinical Trials;Recommendation;Reporting;Reproductive Health;research clinical testing;Resources;response;Rural;Sales;screening;secondary outcome;Social support;Socioeconomic Status;Subgroup;success;Symptoms;Target Populations;Testing;Time;Translating;usability;Weight Gain;White Women;Woman;Work

PROJECT_TITLE: Clinical Testing and Refinement of BumptUp®: A mobile health app to increase physical activity and improve obstetric outcomes among pregnant and postpartum women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ORG_CITY: CHICAGO

ORG_NAME: O2M TECHNOLOGIES, LLC

ORG_STATE: IL

PHR: Narrative Physiological parameters such as oxygen and pH that define the tissue microenvironment affect multiple pathologies, from cancer and inflammation to wound healing. This project will develop a multifunctional continuous wave and pulse mode electron paramagnetic resonance imager to obtain three-dimensional maps of oxygen and pH.

PI_NAMEs: KOTECHA, MRIGNAYANI  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TITLE: Multifunctional EPRI Instrument to Advance Therapies in Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (13)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: CAMDEN

ORG_NAME: VASARYA THERAPEUTICS, INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE This Phase I STTR proposal aims to validate a novel therapeutic approach for liver fibrosis treatment. Liver fibrosis represents a significant financial burden on the U.S. health system and to date there are no FDA-approved drugs to combat this disease.

PI_NAMEs: SHETTY, JAGATHPALA  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Adult;Antibodies;Apoptosis;Area;Benchmarking;Binding;Biochemical;Biological Assay;Biophysics;Biotechnology;Carbon Tetrachloride;CCL4 gene;cell transformation;Cells;Cessation of life;Cholestasis;Chronic Disease;chronic liver injury;Cicatrix;Cirrhosis;Clinical;clinical translation;Collagen;combat;Data;Deposition;Direct Costs;Disease;Drug Controls;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy testing;Epitopes;Etiology;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;Facilities and Administrative Costs;FDA approved;Feedback;Fibroblasts;fibrogenesis;Fibronectins;Fibrosis;Financial Hardship;Genes;Genetic;Goals;Health system;Healthcare Systems;Hepatic;Hepatic lobule;Hepatic Stellate Cell;Histologic;Histology;Human;human data;Hydroxyproline;Impairment;In Vitro;in vivo;innovation;Integrins;Investments;Left;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;Liver parenchyma;Mesenchymal;Metabolic syndrome;Modeling;Molecular Conformation;Mus;Myofibroblast;Nature;non-alcoholic fatty liver disease;novel strategies;novel therapeutic intervention;novel therapeutics;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pirfenidone;Portal Hypertension;pre-clinical;Prevalence;Process;Pulmonary Fibrosis;receptor;Reporting;Research;Resolution;Safety;side effect;Small Business Technology Transfer Research;stellate cell;Therapeutic;Tissue Sample;Tissues;translational potential;United States;wound healing

PROJECT_TITLE: Targeting a disease-specific conformation of fibronectin as a novel approach for liver fibrosis treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (10)]


ORG_CITY: San Jose

ORG_NAME: WELLSIM BIOMEDICAL TECHNOLOGIES, INC.

PHR: PROJECT NARRATIVE Conventional approaches to characterizing extracellular vesicles (EVs) often analyze the entire sample population (bulk analysis), neglecting the inherent EV heterogeneity and failing to quantify EV subpopulations within biofluids. Our proposed technique aims to address these unmet needs by facilitating multimodal studies at the single-EV level, thereby offering significant advantages to the broader EV research community. Its exceptional resolution and sensitivity are poised to accelerate EV-based biomarker discovery and advance the field of precision medicine. Moreover, this innovative method will facilitate the multimodal analysis of low- abundance EV samples, while also serving as an advanced quality control tool for EV-based drug delivery.

PI_NAMEs: CHEN, YUCHAO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Address;Affect;analytical method;Bar Codes;Biogenesis;Biological;Biological Assay;Biological Process;biomarker discovery;Biomedical Technology;Clinical;Code;Communities;Dedications;design;Detection;Development;Diagnosis;Diagnostic;Diameter;Dimensions;Disease;Drug Delivery Systems;Ensure;Exhibits;exosome;extracellular vesicles;Failure;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Heterogeneity;Hybrids;improved;Individual;individual variation;innovation;insight;Insulin-Dependent Diabetes Mellitus;Label;Libraries;Liquid substance;Membrane Proteins;Messenger RNA;Methods;Microfluidics;multimodality;multiple omics;neglect;next generation sequencing;Outcome;phase 1 study;Plasma;Poly T;Population;precision medicine;Preparation;protein expression;Proteins;Protocols documentation;Quality Control;Reagent;Research;Resolution;RNA;Sampling;Small Business Innovation Research Grant;Subgroup;Surface;System;Systems Integration;targeted treatment;Techniques;technological innovation;Technology;Testing;Tissues;tool;transcriptome sequencing;Untranslated RNA;Urine;Variant

PROJECT_TITLE: Multi-omics profiling of individual exosomes for origin-tracing, biomarker discovery, and biological function characterization


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Huntington's Disease;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Orphan Drug;Rare Diseases

ORG_NAME: AYANA BIO LLC

PHR: NARRATIVE Plants contain bioactive compounds with a range of therapeutic uses. But whole soil-grown plants—be they wild- crafted or farmed—are cultivated and harvested with unsustainable practices. Further, bioactive production in these plants is difficult to control and standardize. By contrast, plant cell culture technology is scalable, safe, and environmentally friendly. But the technology has not sufficiently advanced to meet mass market commercial imperatives like consistent high cell density and bioactive titers. Ayana Bio is developing a platform called ASCENT (Analyze to Scale Cellular ENhancement Technology) to produce plant-specific bioactives at large scales in a cost- effective manner.

PI_NAMEs: GLENN, WESLEE SINCLAIR (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Alzheimer's Disease;Anti-Inflammatory Agents;Antioxidants;Anxiety;Aspirin;Attention deficit hyperactivity disorder;Biological Assay;Brain Diseases;Caenorhabditis elegans;CAG repeat;Cell Culture Techniques;Cell Density;Cell Line;Cells;Chemicals;Clinical;Clinical Trials;commercialization;comparison control;Consumption;cost;cost effective;crocetin;Crocus sativus;Data;Data Set;Development;dietary supplements;Disease;disease phenotype;Dose;Engineering;Enhancement Technology;Environment;Enzymes;Ethics;Exhibits;Farm;FDA approved;Fermentation;Food;Friends;Genes;Genetic Engineering;Growth;Harvest;Health;high throughput screening;Human;Huntington Disease;Huntington gene;improved;Individual;Investigation;Ischemic Stroke;Lead;Learning;Machine Learning;manufacture;manufacturing facility;Marketing;Mental Depression;metabolomics;Methods;Microbe;Microfluidics;Modeling;Modern Medicine;Motility;Multiple Sclerosis;mutant;Nervous System;neurocognitive disorder;neuroprotection;No-Observed-Adverse-Effect Level;novel;Obsessive-Compulsive Disorder;Oral;Organelles;overexpression;Paclitaxel;Parkinson Disease;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phytochemical;Plants;polyglutamine;Power Plants;pre-clinical;Production;protein aggregation;Quinine;Randomized Controlled Clinical Trials;Rattus;Recording of previous events;Reproducibility;Safety;Saffron;scale up;screening;Soil;Speed;Standardization;Stress;stressor;Technology;Terpenes;Testing;Therapeutic;Therapeutic Research;Therapeutic Uses;Time;timeline;Toxic effect;Toxicology;transcriptomics;World Health Organization;Writing

PROJECT_TITLE: Engineering Saffron Plant Cell Culture to Produce Neuroprotective Bioactives

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ORG_CITY: FORT WORTH

ORG_NAME: KINETIQ THERAPEUTICS LLC

ORG_STATE: TX

PHR: Public Health Relevance Fabry disease is a rare genetic disorder that damages the kidneys and heart and causes potentially life- threatening complications over time. Current treatments for Fabry disease require life-long, frequent intravenous infusions performed in hospitals or infusion centers which imposes significant therapeutic preconditions and burdens on patients while reducing their quality of life. To solve these challenges, Kinetiq is developing a more convenient self-administrable therapy that will shift Fabry disease care into the outpatient setting while improving patient well-being and expanding treatment accessibility.

PI_NAMEs: CAO, MINGJU  (contact)

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: absorption;Adoption;Adult;Affect;Alpha-galactosidase;Ambulatory Care;Animals;Biological Sciences;Blood capillaries;Caring;cell type;Child;Chronic Kidney Failure;Clinical;clinical efficacy;Clinical Trials;commercial application;comparative efficacy;Complex;cost;Costs and Benefits;Development;Disabling;Disease;Dose;drug distribution;Early treatment;enzyme replacement therapy;enzyme therapy;Enzymes;Epithelium;experience;Fabry Disease;Failure;Feasibility Studies;Female;Focus Groups;Formulation;Future;gene therapy;genetic manipulation;Glycolipids;health care service utilization;Heart;Hereditary Disease;Histology;Hospitals;Hour;Image;immunogenicity;Immunohistochemistry;improved;Infection;infection risk;Infusion procedures;inhibitor therapy;Injections;Inpatients;Intervention;Intravenous;Intravenous infusion procedures;Kidney;Kinetics;Lead;Legal patent;Life;Life Expectancy;Lysosomal Storage Diseases;male;Marketing;Mass Spectrum Analysis;Metabolism;Methods;Modality;Morbidity - disease rate;Mus;Names;Nerve Fibers;Operative Surgical Procedures;Organ;Outcome;Outpatients;Patients;Penetration;Peripheral;Personal Satisfaction;Persons;Phase;phase 2 study;Physical activity;Physiological;post intervention;preclinical efficacy;Prevalence;product development;Productivity;productivity loss;prospective;public health relevance;Puncture procedure;Quality of life;rare genetic disorder;Reaction;Recurrence;response;Risk;Rodent;Safety;side effect;Small Business Innovation Research Grant;social anxiety;Social Discrimination;Stains;standard of care;subcutaneous;Technology;Testing;Texas;Therapeutic;Time;Tissues;Treatment Cost;Treatment Efficacy;Tubular formation;Veins;Venous;Viral Genes;Work

PROJECT_TITLE: Preclinical Efficacy of Subcutaneous Enzyme Therapy for Lysosomal Fabry Disease


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: PAVMED INC.

ORG_STATE: NY

PHR: NARRATIVE The proposed project to optimize and validate the Veris Health Cancer Care Platform for underserved and low socioeconomic status cancer patients is highly relevant to public health. This technology has the potential to improve patient outcomes, reduce healthcare costs, and increase access to care for vulnerable populations. By providing patients with at-home monitoring devices and remote communication with their care team, this platform addresses critical gaps in cancer care, leading to better management of treatment-related toxicities and reduced rates of preventable hospitalizations.

PI_NAMEs: MITCHELL, JAMES  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adherence;Area;barrier to care;bilingualism;cancer care;Cancer Patient;cancer therapy;Caring;chemotherapy;Clinical;cohort;Communication;Computer software;cost;Cost Savings;Data;Data Analyses;Dedications;design;Diarrhea;Disparity;Dose;Early Diagnosis;Early Intervention;Early treatment;Economic Burden;Economics;effectiveness validation;Emergency department visit;Ensure;Equipment and supply inventories;EuroQOL;Family member;Feedback;Focus Groups;Future;General Population;Goals;Health;Health Care Costs;health care disparity;Health Personnel;health related quality of life;Health Services Accessibility;Healthcare;high risk;Home;Hospitalization;Hospitals;improved;improved outcome;indexing;Infection;Information Networks;insight;Interruption;Intervention;Interview;Intuition;Investigation;Language;Linguistics;Longitudinal trends;low socioeconomic status;Malignant Neoplasms;Marketing;Measurement;Measures;Medical Care Team;medically underserved;Methods;Minority;mobile application;monitoring device;Nausea;Neighborhood Health Center;New Jersey;novel strategies;Oncology;Outcome;outcome disparities;Outpatients;Patient Compliance;patient engagement;Patient Monitoring;patient population;Patient-Focused Outcomes;patient-level barriers;Patients;Physiologic Monitoring;preference;prospective;Public Health;Quality of life;Questionnaires;Randomized;remote patient monitoring;Reporting;Research;Research Design;Risk;social;socioeconomic disparity;Socioeconomic Status;socioeconomics;Spanish;Statistical Data Interpretation;Symptom Burden;Symptoms;System;Technology;Telemedicine;Testing;tool;Treatment Side Effects;Treatment-related toxicity;trend;trend analysis;Underserved Population;United States;usability;user centered design;Visit;Vulnerable Populations;web app

PROJECT_TITLE: Bridging the Gap: Enhancing Cancer Care for Underserved Populations with the Veris Health Cancer Care Platform


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Diabetes;Dietary Supplements;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: TROY

ORG_NAME: EPIC NUTRITION FOR Y LLC

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Developing a sustainable long-term solution for obesity management is a significant challenge, as current approaches are often difficult to maintain. This project seeks to address this issue by introducing a novel probiotic, Clostridium cochlearium 2316 (CC), as a safe and effective dietary intervention that is easy to follow and long lasting. Through dietary supplementation of CC, promising results in mice consistently showed significant modification of gut microbiota and reduced obesity, offering a potential avenue for the development of a safe and long-term sustainable nutritional intervention to prevent and treat obesity.

PI_NAMEs: JI, XIANGMING ;ZHOU, KEQUAN  (contact)

PROJECT_TERMS: absorption;Acute;Address;Adherence;Adverse effects;Affect;American;Anaerobic Bacteria;Antibiotic Resistance;Bacteria;Bile Acids;Binding;Biological;blood glucose regulation;Body fat;Body Weight;Chronic;Classification;Clinical;Clinical Trials;Clostridium;Colon;commensal bacteria;Consumption;cost;Data;Development;Diabetes Mellitus;diet-induced obesity;dietary;Dietary Intervention;Dietary Supplementation;dietary supplements;Disease;Dose;Drug Kinetics;Eating;efficacy evaluation;Energy Metabolism;Ensure;Environment;Epidemic;Evaluation;Excretory function;Food;Food Supplements;Formulation;Future;Gastrointestinal tract structure;glucose tolerance;Goals;Guidelines;gut microbiome;gut microbiota;High Fat Diet;Human;in vivo;Ingestion;innovation;insight;Insulin Resistance;insulin sensitivity;Intake;interest;Investigation;Investigational Drugs;Laboratories;Legal;Legal patent;Link;Literature;Liver;Mammals;medical food;Medicine;Metabolic;Modification;Monitor;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutraceutical;nutritional approach;Obese Mice;Obesity;obesity development;Obesity Epidemic;obesity management;obesity treatment;Organism;Outcome;Pathogenicity;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Plasma;pre-clinical;Pre-Clinical Model;preclinical toxicity;prevent;Preventive;Probiotics;product development;protective effect;Public Health;Publications;Reducing diet;Regulatory Pathway;Reproduction spores;Research;research clinical testing;resistance gene;restoration;Risk;Rodent;Safety;safety assessment;Site;Structure;success;Therapeutic;Time;Tissues;Toxic effect;United States;Virulence Factors;Volatile Fatty Acids;Weight Gain;Weight maintenance regimen

PROJECT_TITLE: A Novel Probiotic with The Potential for Long-term Management of Obesity and Insulin Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (10)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Transplantation

ORG_CITY: CLEVELAND

ORG_NAME: COLLAMEDIX INC.

ORG_STATE: OH

PHR: Narrative Anterior cruciate ligament reconstructions (ACLR) with allografts only account for 22%-44% of U.S. procedures because allografts have a high failure rate (8%-25%), making them not recommended for children and athletes, which is due, in part, to poor ligamentization throughout the graft and weak bone-graft integration within the bone tunnels. To reduce the chance of allograft failure, CollaMedix Inc. has developed AlloBrace, a pure collagen braided sheath with osteoinductive coated ends, that will induce new tissue growth throughout the allograft and promote true bony junctions between the bone-graft which will improve biomechanical allograft properties and increase pull out strength of the allograft, leading to a more stable knee. The proposed project will determine the feasibility of AlloBrace as a purely biological enhancement for allograft to advance ACLR by testing the implants delivery around an anterior tibialis allograft and the devices tenoinductive and osteoinductive properties in a in vivo pilot study using a physiologically relevant ACLR animal model, previously used for testing orthobiologics medical devices.

PI_NAMEs: DENNY, CHRISTIAN T.;SHANKAR, SUBBA  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: allogenic bone transplantation;Allografting;Animal Model;Annual Reports;Anterior;Anterior Cruciate Ligament;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Athletic;Autologous Transplantation;Benchmarking;Biological;Biology;Biomechanics;bone;Bone Growth;Bone Transplantation;Businesses;Cadaver;Cells;Cellular Infiltration;Cellularity;Child;Chronic;Cicatrix;Collagen;Collagen Type I;Connective Tissue;Contralateral;crosslink;Cytoskeleton;Data;Deposition;design;Development;Devices;Diameter;Equation;Equipment;Euthanasia;Evaluation;Exposure to;fabrication;Failure;Family;Family suidae;Female;Future;genipin;Grant;Growth;HA coating;Harvest;healing;high risk;Histology;Hydroxyapatites;Immune response;Implant;improved;improved outcome;in vivo;Industrialization;infection risk;Infiltration;Inflammatory;Ipsilateral;joint biomechanics;Knee;knee pain;Lead;Left;Leg;Legal patent;Ligaments;Macrophage;manufacture;manufacturing process;Mechanics;Medical;Medical Care Costs;Medical Device;Mesenchymal;Methods;Mobility decline;Modeling;Morbidity - disease rate;Muscle Weakness;older patient;Operative Surgical Procedures;Orthopedics;Outcome;Patients;Peptide Hydrolases;Performance;Peripheral;Phase;Phenotype;Physiological;Pilot Projects;porcine model;Porosity;prevent;Procedures;Process;Production;Property;Recommendation;reconstitution;Recovery;regenerative;Research;Risk;rotator cuff tear;scale up;Site;Slide;soft tissue;stem cells;Surgeon;Surgical sutures;Synovial Fluid;System;Techniques;Tendon structure;Tensile Strength;Testing;Textiles;Thick;tibialis anterior muscle;Time;Tissues;tool;Tubular formation;Urinary Incontinence;Work;wound healing

PROJECT_TITLE: AlloBrace: Pure Collagen Augment to Improve Performance and Integration of Allografts


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lymphatic Research;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: BIG EYE DIAGNOSTICS, INC.

PHR: PROJECT NARRATIVE Lymphatic filariasis is a painful and disfiguring disease caused by roundworms which affects 40 million people worldwide. Massive elimination programs, led by WHO and local ministries of health, require sensitive and specific rapid tests to certify that countries are disease free and to conduct post-elimination surveillance activities, and WHO has therefore published a Target Product Profile (TPP) in 2021 defining the criteria that new tests must meet. We now propose such a new test, which is fully compliant with the TPP and able to rapidly and accurately detect infection by Brugia species, one of the two species of worms that cause lymphatic filariasis.

PI_NAMEs: BIAMONTE, MARCO ANTONIO (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adopted;Adoption;Advisory Committees;Affect;Agency for International Development;Agreement;Antibodies;Antigens;Biological;Blood;Brugia;burden of illness;Certification;chemotherapy;commercialization;commercialization readiness;comparative;cost;cost effective;Country;Data;Devices;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;disability-adjusted life years;Disease;Dryness;Enzyme-Linked Immunosorbent Assay;Equipment;field study;Filaria bancrofti;Filarial Elephantiases;Formulation;Foundations;Friends;Funding;Future;global health;Goals;Health;IgG4;Indonesia;Infection;Infrastructure;Laboratories;Laboratory Study;large scale production;Life;Malaysia;manufacture;manufacturing process;manufacturing quality;Maps;meetings;Methods;Microscopy;National Institute of Allergy and Infectious Disease;Nematoda;novel diagnostics;Pain;Parasites;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Plasma;point of care;Politics;portability;Preventive;Preventive treatment;Procedures;Process;Production;programs;Proteins;Protocols documentation;prototype;public health relevance;Publishing;quality assurance;Quality Control;Rapid diagnostics;rapid test;Reagent;Recommendation;Research;Route;sample collection;Sampling;Secure;Sensitivity and Specificity;Signal Transduction;Southeastern Asia;Specific qualifier value;Specificity;Spottings;Surveys;Technology;Technology Transfer;Testing;Time;transmission process;Trust;United States National Institutes of Health;Validation;Vendor;Work

PROJECT_TITLE: Supporting WHO Lymphatic Filariasis Elimination Programs: Progressing a Highly Sensitive and Specific Rapid Diagnostic Test for Brugia Species Infection to Commercialization Readiness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


ORG_CITY: SALT LAKE CITY

ORG_NAME: CATHPRO TECHNOLOGIES LLC

ORG_STATE: UT

PHR: NARRATIVE Vascular catheters provide access to the blood for therapy, nutrition, and/or removal of toxins and metabolites. Infection and occlusions are the most common complications with these devices which can seriously affect patient health and can lead to death. In addition, the US healthcare system spends billions of dollars each year to address these complications. The proposed SBIR project intends to study a unique approach to reduce catheter infections and occlusions and improve patient health.

PI_NAMEs: THIAGARAJAN, GIRIDHAR  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acceleration;Accidents;Address;Affect;Alteplase;Anti-Infective Agents;antimicrobial;Antimicrobial Effect;Biological Assay;biomaterial compatibility;Blood;Blood flow;Blood Vessels;Candida albicans;Catheters;Cattle;Cessation of life;Citrates;Coagulation Process;commercialization;Confidential Information;controlled release;Copper;design;Development;Devices;Diameter;Distal;Dose;Ethanol;Evaluation;Event;Excision;experience;Experimental Designs;experimental study;Exposure to;fabrication;Feasibility Studies;flexibility;Future;Goals;Growth;Health;Healthcare Systems;Heparin;Hospitals;Hour;improved;In Vitro;in vitro Model;Inductively Coupled Plasma Mass Spectrometry;Industry;Infection;Infection prevention;Infusion procedures;Intervention;Legal patent;Length;Letters;Life;light scattering;Marketing;Measures;Mechanics;Microbe;microbial;Microbial Biofilms;microbial colonization;Modeling;Morbidity - disease rate;mortality;new technology;novel;nutrition;Particulate;pathogen;Patients;Performance;Pharmaceutical Preparations;Phase;phase 1 study;Pre-Clinical Model;pressure;prevent;Preventive measure;Procedures;product development;Property;Pseudomonas aeruginosa;Research;Rest;Risk;Safety;Saline;Sample Size;screening;Serum;Small Business Innovation Research Grant;Stainless Steel;Staphylococcus epidermidis;Stream;success;Techniques;Technology;Tensile Strength;Testing;Thinness;thrombotic;Thrombus;Time;Toxin;Variant;Wait Time

PROJECT_TITLE: BIOACTIVE LUMINAL INSERT TO REDUCE CATHETER INFECTIONS AND THROMBOTIC OCCLUSIONS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-W (12)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: EAST LANSING

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative This project concerns the innovation in mathematical artificial intelligence (AI) to advance the forefront of pandemic forecasting, drug discovery and directed evolution. The resulting new generation of AI tools, algorithms, and technologies will enable the data-driven discovery in biological sciences.

PI_NAMEs: WEI, GUOWEI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 2019-nCoV;Address;algebraic topology;Algorithms;Artificial Intelligence;Artificial Intelligence platform;Biological Sciences;combinatorial;Computer Assisted;Data;differential geometry;Directed Molecular Evolution;Drug Design;drug discovery;empowerment;Evolution;Generations;Genome;Graph;Human;innovation;laboratory experiment;Mathematics;Modeling;Mutation;pandemic disease;Play;Proteome;Recording of previous events;Research;Role;SARS-CoV-2 variant;Series;Site;success;Technology;tool;transmission process;Variant;Viral

PROJECT_TITLE: Discovery-Driven Mathematics and Artificial Intelligence for Biosciences and Drug Discovery

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Chronic kidney disease (CKD) and End-Stage Renal Disease (ESRD) affect over 37 million Americans, or approximately 15% of the population. Bacterial infections are the second leading cause of death in ESRD and are an important cause of hospitalization. B cells are important components of the immune response to infections. CKD and ESRD affect the ability of B cells to make antibodies that fight bacteria and respond to vaccines, thus leaving Veterans vulnerable to infection. Therefore, understanding how CKD and ESRD reduce the ability of B cells to make antibodies would represent a key therapeutic advance that would improve Veteran care. We propose novel experiments to understand B cell impairment in Veterans with CKD and ESRD that we expect to lead to new therapies.

PI_NAMEs: JANI, ALKESH HARIHAR (contact);JANOFF, EDWARD N

PROJECT_TERMS: activation-induced cytidine deaminase;Adult;Affect;Affinity;Age Years;American;Antibodies;antibody and antigen binding;Antibody Formation;Antibody Response;antigen binding;Avidity;B-Lymphocyte Subsets;B-Lymphocytes;Bacteria;Bacterial Infections;Bacterial Pneumonia;Blood;capsule;Caring;Cause of Death;Cell Communication;Cell Maturation;Cell Nucleus;Chronic;Chronic Kidney Failure;Cytoplasm;Data;Death Rate;Defect;Development;Dialysis patients;Dialysis procedure;differential expression;DNA;End stage renal failure;Enzyme Activation;Enzymes;experimental study;fighting;Frequencies;Gene Mutation;General Population;Genes;Helper-Inducer T-Lymphocyte;Hospitalization;IgA1;IgG1;Immune response;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Constant Region;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulin-Secreting Cells;Impairment;improved;Incidence;Infection;Inflammation;interleukin-21;Interleukin-4;Interleukin-6;Kidney Diseases;Lymphoid;Messenger RNA;Mucous Membrane;Mutation;Nasopharynx;novel;novel therapeutics;Nuclear;Patients;Pattern;Persons;Pneumococcal conjugate vaccine;Pneumococcal Pneumonia;Pneumococcal vaccine;Pneumonia;Polysaccharides;Polyvalent pneumococcal vaccine;Population;Process;Production;protein expression;Proteins;recruit;Respiratory Mucosa;response;Specificity;Streptococcus pneumoniae;Structure of germinal center of lymph node;Structure of mucous membrane of nose;T-Lymphocyte;Therapeutic;TNF gene;TNFSF5 gene;Vaccination;vaccination outcome;vaccine development;vaccine response;Vaccines;Veterans

PROJECT_TITLE: Impaired B Cell and Vaccine Responses with Advance Renal Disease


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The timely and coordinated destruction of proteins requires a complex set of large molecular machines to drive the cell cycle and cell division. At the core of the cell cycle oscillator is the 1.2 MDa, multi-subunit ubiquitin ligase known as the Anaphase-Promoting Complex/Cyclosome, whose activity must be strictly regulated by post- translational modifications and inhibitors, such as the Mitotic Checkpoint Complex. The proposed research will allow for a detailed understanding of mitosis and how dysregulation of this machinery results in developmental defects and cancer progression.

PI_NAMEs: BROWN, NICHOLAS GENE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: anaphase-promoting complex;ATP phosphohydrolase;Binding;cardiogenesis;Cell Cycle;Cell Cycle Checkpoint;Cell division;Cellular biology;Chromatin;Chromosome Segregation;Chromosomes;Complex;Coupling;Cryoelectron Microscopy;Cyclin B;daughter cell;Defect;Development;Disease;Ensure;Eukaryotic Cell;Event;G1 Phase;Gene Expression;Gene Proteins;Genetic Transcription;In Vitro;inhibitor;innovation;Malignant Neoplasms;Mitosis;Mitotic;Mitotic Checkpoint;Molecular Conformation;Molecular Machines;Nucleosomes;Phosphotransferases;Photometry;Polyubiquitination;Post-Translational Protein Processing;Process;protein degradation;Proteins;PTTG1 gene;reconstitution;Regulation;Research;scaffold;Techniques;Time;tumor progression;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Spindle Assembly Checkpoint Silencing

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: PROJECT NARRATIVE This project will collect data on early childhood risk factors for eating disorders in female children ages 6-12. The proposed research has significant public health relevance, as it will enhance our understanding of how eating disorders develop and for whom, leading to early detection and prevention efforts. The proposed research is relevant to NIMH’s strategic aim 3.1. A to strive for prevention based on an understanding of risk, as it will lead to tools that can better identify early risk factors, as well as prevention efforts directly targeting mechanisms predictive of the onset of early eating disorders and related pathology.

PI_NAMEs: BUFFERD, SARA J;LEVINSON, CHERI ALICIA (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 12 year old;Adolescence;Adolescent;Age;Age of Onset;Anxiety;Anxiety Disorders;Behavior;Behavioral;bodily sensation;body dissatisfaction;Body Size;Brain;Cessation of life;Characteristics;Child;Childhood;childhood anxiety;Chronic;Clinical;Cognition;Cognition Disorders;Cognitive;cohort;Control Groups;cost;Data;Death Rate;design;Development;Diagnosis;Diagnostic;dieting;Down's Syndrome;early adolescence;early childhood;Early Diagnosis;Early identification;Early Intervention;early onset;Eating;Eating Behavior;Eating Disorders;Esthesia;Etiology;Exhibits;experience;Extinction;Family;Fasting;Female;follow-up;Fright;gastrointestinal system;girls;Goals;Health;High Prevalence;high risk;Hyperphagia;Hypersensitivity;Impairment;improved;Individual;innovation;insight;Interoception;Knowledge;Lead;Learning;Link;Literature;Malignant Neoplasms;maternal anxiety;Mental Depression;Mental disorders;multimodality;National Institute of Mental Health;negative affect;Non-Insulin-Dependent Diabetes Mellitus;novel;Occupations;Onset of illness;opioid use;Parents;Pathology;Physiological;Population;Predisposing Factor;Prevention;Prevention program;prospective;public health relevance;Recording of previous events;recruit;Reporting;Research;restraint;Risk;Risk Factors;Sampling;social anxiety;societal costs;Societies;standard care;Sudden infant death syndrome;Symptoms;Testing;theories;Time;tool;Traction;United States;Work;Youth

PROJECT_TITLE: Anxiety and Interoception Risk for Eating Disorders in Childhood

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: KANSAS CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative DNA damage arising from oxidative stress promotes multiple human diseases, and the primary cellular defense against this oxidative DNA damage is the multi-protein base excision repair (BER) pathway. The overarching goal of this proposal is to understand the molecular mechanisms of each BER factor both individually and within larger multi-protein/DNA complexes using naked duplex DNA and nucleosomes. We will employ elegant biophysical approaches to elucidate inherent BER complexities, while providing both a foundation for interpreting the biological response and the subsequent development of rational therapeutic treatments towards enhancing human health.

PI_NAMEs: FREUDENTHAL, BRET D (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Base Excision Repairs;Biological;biophysical techniques;Cell model;Cells;Chromatin;Complex;Cryoelectron Microscopy;Dangerousness;Development;DNA;DNA Damage;DNA Repair;DNA Repair Gene;DNA Structure;DNA-Directed DNA Polymerase;Drug Combinations;Drug Design;Enzyme Kinetics;Enzymes;Foundations;Genome Stability;Goals;Hand;Health;Human;human disease;Individual;interdisciplinary approach;Malignant Neoplasms;Methodology;Microscopy;Modification;Molecular;molecular dynamics;Multiprotein Complexes;Mutagenesis;novel therapeutics;Nucleosomes;oxidative DNA damage;Oxidative Stress;Pathway interactions;Positioning Attribute;Proteins;Repair Complex;repair enzyme;repaired;response;Role;Scientific Advances and Accomplishments;single molecule;Telomerase;telomere;Therapeutic;therapeutic development;X-Ray Crystallography

PROJECT_TITLE: Structural and Mechanistic Studies of DNA Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will fill knowledge gaps that can help lay the groundwork for the development of innovative and effective biologic therapies for meniscus injury repair in order to delay/prevent degenerative joint disease. This research is aligned with the NIH’s mission that pertains to seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to reduce illness and disability.

PI_NAMEs: JAYASURIYA, CHATHURAKA TEEKSHANA (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Affect;Animal Model;Animals;Arthritis;articular cartilage;Attenuated;base;Behavior;Biocompatible Materials;Biological Markers;Biological Products;Biological Response Modifier Therapy;biomaterial compatibility;Cartilage;Cells;Cellular Structures;chemokine;Chemotactic Factors;Chondrogenesis;clinical translation;clinically relevant;Collagen;Collagen Fiber;Complex;Control Animal;Data;Degenerative polyarthritis;Development;disability;Dose;Effectiveness;efficacy evaluation;Evaluation;Exhibits;experimental group;Extracellular Matrix;Fast Green;Fibrin;Fibrinogen;Fibrocartilages;Flow Cytometry;Gait;Gel;Gene Proteins;Goals;Green Fluorescent Proteins;healing;Histologic;Histology;Histopathology;Human;Hydrogels;Image;improved;in vivo evaluation;Injectable;Injury;injury and repair;innovation;Knee;Knee Injuries;Knee joint;Knowledge;Laboratories;lymph nodes;Magnetic Resonance Imaging;Measures;Mechanics;Medial meniscus structure;Mediator;meniscal tear;meniscus injury;Meniscus structure of joint;Mesenchymal Stem Cells;Microscopic;Miniature Swine;Mission;Modeling;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;novel;Organ Culture Techniques;Organism;Orthopedics;Outcome Assessment;Outcome Measure;Patients;Plasma;polarized light;porcine model;pre-clinical;prevent;Prevention;Production;Proteoglycan;Public Health;Rattus;repaired;Reporting;Research;Research Design;response;Risk Factors;scaffold;Severities;Sirius Red F3B;Site;small molecule;Stains;stem cells;Stromal Cell-Derived Factor 1;success;Surgical sutures;Synovial Fluid;Synovial Membrane;Technology;Testing;Thrombin;Time;Tissue Model;Tissues;Translating;Translations;Traumatic Arthropathy;treatment response;United States National Institutes of Health;Urine;Visualization

PROJECT_TITLE: Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Identifying molecular mechanisms underlying chromosome maintenance and gene expression in eukaryotes is critical for our understanding of genome biology and cellular homeostasis and physiology. This proposal will investigate our recent discovery about a novel regulatory mechanism of human genome by a protein called 53BP1. Upon completion, this study will reveal innovative insights into the maintenance of DNA structure, transcriptome, and genome stability, representing a conceptual leap in our understanding of biology and cellular physiology.

PI_NAMEs: ZHANG, YOU-WEI  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3-Dimensional;Address;Biochemical;Bioinformatics;Biological;Biological Process;Biology;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cellular Stress;Chemicals;Chromatin;Chromatin Structure;chromosome conformation capture;Chromosome Segregation;Chromosomes;Co-Immunoprecipitations;Complex;Coupled;crosslink;Cues;Cytoprotection;Dimensions;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Maintenance;DNA metabolism;DNA replication fork;DNA Replication Timing;DNA Structure;domain mapping;Double Strand Break Repair;Embryo;epigenetic marker;epigenetic memory;Epigenetic Process;Euchromatin;Eukaryota;Fibroblasts;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Genome;Genome Stability;Goals;HDAC1 gene;Heterochromatin;Hi-C;Histone Acetylation;Histones;Homeostasis;Human;Human Genome;In Vitro;information processing;innovation;insight;intermolecular interaction;Knock-out;Knockout Mice;light scattering;Liquid substance;Location;Maintenance;Mass Spectrum Analysis;MCF10A cells;Mediating;Mediator;Membrane;Molecular;Molecular and Cellular Biology;Molecular Sieve Chromatography;Morphology;Mus;mutant;next generation sequencing;Non-Malignant;novel;Nuclear;nuclease;Nucleic Acids;Nucleotides;Organelles;p53-binding protein 1;Phase;Physiology;Play;Polymers;Process;Proteins;Proteomics;reconstitution;recruit;repair function;repaired;Reporting;Research;restoration;Role;Science;senescence;Signal Transduction;stoichiometry;Structure;Sumoylation Pathway;Testing;three dimensional structure;transcriptome;transcriptome sequencing;whole genome

PROJECT_TITLE: 53BP1 regulates genome biology and cellular physiology through liquid phase separation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Lung;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: PROJECT NARRATIVE Although progression of Multiple Sclerosis (MS) can be radically slowed with newer medications, no treatment is available for alleviating existing motor deficits, which vastly affect the quality of life in people with MS. In this study, we examine an emerging therapy - acute intermittent hypoxia (AIH) - that strengthens neural circuits and ultimately enhances movement ability in spinal cord injury, and may have similar benefits in MS. The results of this project, which include measures of lower-limb function and brain imaging, will inform clinical researchers if this therapy is viable for treating MS symptoms.

PI_NAMEs: BRIGHT, MOLLY G;SANDHU, MILAPJIT SINGH (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acute;Adverse effects;Affect;Air;Ankle;Autoimmune;Automobile Driving;Bilateral;Brain imaging;Brain-Derived Neurotrophic Factor;burden of illness;Central Nervous System;Central Nervous System Diseases;Chronic;Clinical;Clinical Research;Clinical Trials;cognitive function;Combined Modality Therapy;common symptom;Communities;Cross-Over Studies;Cross-Over Trials;Data;Demyelinating Diseases;design;Development;dexterity;disability;Disabling;Disease;Disease remission;Dose;Double-Blind Method;effective therapy;Effectiveness;Enrollment;Exposure to;extend lifespan;Frequencies;Functional impairment;functional improvement;Functional Magnetic Resonance Imaging;functional plasticity;Goals;Hand;high reward;high risk;Hypoxia;Imaging Techniques;Immune;improved;Individual;insight;Intervention;Light;Limb structure;loss of function;Lower Extremity;magnetic resonance imaging biomarker;Maps;Measures;Mediating;Monitor;Motor;motor control;motor deficit;motor function improvement;motor function recovery;Motor Neurons;motor rehabilitation;motor symptom;Movement;MRI Scans;Multiple Sclerosis;multiple sclerosis patient;Myelin;neural;neural circuit;Neural Pathways;Neurodegenerative Disorders;neuroimaging;neuromechanism;Neuronal Plasticity;North America;novel;novel therapeutic intervention;Oxygen;participant safety;Patients;Persons;Pharmaceutical Preparations;Phase;Physical activity;Physiological;Placebo Control;post intervention;programs;Proteins;Protocols documentation;Publishing;Quality of life;Radiology Specialty;Randomized;Recovery;Recovery of Function;rehabilitation strategy;Rehabilitation therapy;Relapse;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;respiratory;Respiratory physiology;Rest;Rodent;Safety;Seminal;Serotonergic System;serotonin receptor;Spinal cord injury;Spinal cord injury patients;Symptoms;Synapses;Synaptic Transmission;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Torque;Training;United States;United States National Institutes of Health;Walking;walking performance;walking speed;Work

PROJECT_TITLE: Intermittent Hypoxia Initiated Motor Plasticity in Individuals with Multiple Sclerosis

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

PHR: Veterans Health Administration (VHA) developed a program of enhanced usual care (EUC) for Veterans who have experienced suicidal crises that includes care coordination, safety plans, and 24-hour crisis hotline access. Despite these efforts, suicide rates following such crises have plateaued. Motivational Interviewing to Address Suicidal Ideation was revised (MI-SI-R) to help Veterans resolve ambivalence about living by increasing the motivation to live. The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the efficacy of MI-SI-R+EUC to reduce risk for suicide attempts and suicidal ideation over 12 months when compared to EUC alone. The study will also explore the possibility that the efficacy of MI-SI-R+EUC is impacted by suicide attempt history and common psychiatric diagnoses, and that it works by increasing the motivation to live and the motivation to change.

PI_NAMEs: BRITTON, PETER C (contact)

PROJECT_TERMS: Acute;Address;brief intervention;care coordination;Complement;Development;efficacy evaluation;experience;Feeling suicidal;follow up assessment;follow-up;high risk;Hotlines;Hour;innovation;inpatient psychiatric treatment;Intervention;Mediating;Medical center;Mental disorders;Mental Health Services;Modeling;Motivation;motivational enhancement therapy;novel;Participant;Patients;Persons;Population;Prevention strategy;Prevention trial;programs;Psychiatric Diagnosis;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;reducing suicide;Reporting;Research;response;Risk;Risk Assessment;Risk Reduction;Safety;Sampling;Severities;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Telephone;telephone session;Testing;treatment as usual;trial comparing;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Motivational Interviewing to Address Suicidal Ideation: A Randomized Controlled Trial with Suicidal Veterans


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: PTSD is one of the most prevalent mental health conditions affecting Veterans who have served since 9/11. Veterans with posttraumatic stress disorder (PTSD) report difficulty controlling impulsive aggression (IA). An inability to manage one’s emotions (emotion dysregulation) is an underlying mechanism of IA. Reducing IA and increasing use of PTSD evidence-based psychotherapies are two critical missions for the Veterans Health Administration. The proposed research supports these missions by comparing a 3- session emotion regulation treatment (Manage Emotions to Reduce Aggression) to a control group in order to determine if MERA can reduce IA and prepare Veterans for PTSD treatment. By enhancing Veterans’ abilities to cope with trauma-related emotions and feel equipped to initiate PTSD treatments, this research aims to help Veterans decrease IA and ultimately recover from PTSD.

PI_NAMEs: MILES, SHANNON R. (contact)

PROJECT_TERMS: active control group;active method;Address;Affect;Afghanistan;Aftercare;Aggressive behavior;anger management;Awareness;Behavior Control;Behavioral;brief intervention;Cessation of life;Charge;Cognitive;combat veteran;combat zone;Communities;Control Groups;coping;cost;Dropout;Drops;Education;effective therapy;efficacy testing;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;evidence base;experience;Family;Family Violence;follow-up;Frequencies;Fright;Goals;Imprisonment;improved;Impulsivity;innovation;Iraq;Knowledge;Learning;Length;male;Measures;Mediating;Meditation;Mental disorders;Mental Health;Methods;Mission;Modeling;novel;Population;Post-Traumatic Stress Disorders;Psychotherapy;randomized, clinical trials;Regulation;Reporting;Research;Research Support;response;Sampling;Severities;Site;skill acquisition;skills;skills training;Social support;Societies;standard of care;Symptoms;Testing;Time;Training;Trauma;treatment as usual;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Wait Time

PROJECT_TITLE: Manage Emotions to Reduce Aggression - MERA: A Brief Aggression Treatment for Veterans with PTSD Symptoms


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: The proposed project is a randomized clinical trial that will evaluate the efficacy of written exposure therapy (WET) among veterans engaged in substance use disorder (SUD) treatment, who present with co-occurring posttraumatic stress disorder (PTSD). While SUD treatment programs traditionally do not address PTSD, effective trauma treatments have been used successfully among those with substance use comorbidities. WET is a brief trauma-focused intervention shown to effectively treat PTSD. In a recent acceptability and feasibility pilot study among veterans with co-occurring SUD and PTSD, results showed a decrease in PTSD symptoms among participants receiving WET. Additionally, WET participants reported reductions in average days of drug and alcohol use at follow-up. This project will also examine whether heart rate variability, a biological marker of autonomic arousal, is an indicator of treatment efficacy. The goal of the present study is to improve outcomes for veterans who present for SUD treatment with comorbid SUD/PTSD.

PI_NAMEs: MESHBERG-COHEN, SARAH  (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Admission activity;Aftercare;Alcohol consumption;Alcohols;Arousal;Autonomic nervous system;Back;Biological Markers;Buprenorphine;Client satisfaction;Clinic;Clinical;Clinical Trials;Cognitive;comorbidity;comparison control;cost efficient;Data;design;Diagnosis;Distress;Dose;Dropout;Drug usage;dual diagnosis;efficacy evaluation;evidence base;follow-up;Frequencies;Goals;heart rate variability;improved;improved outcome;Intervention;Light;Measures;medical specialties;Mental Depression;Mental Health;Moods;Outcome;Outpatients;Participant;Pharmaceutical Preparations;physical conditioning;Physiological;Pilot Projects;Post-Traumatic Stress Disorders;post-traumatic symptoms;programs;Provider;Psychotherapy;Questionnaires;Randomized;randomized, clinical trials;reduce symptoms;Relapse;Reporting;Rest;satisfaction;Severities;Standardization;Stress;substance use;Substance Use Disorder;suicide rate;symptomatic improvement;Symptoms;Time;timeline;traditional therapy;Training;Trauma;trauma exposure;trauma symptom;treatment as usual;treatment comparison;Treatment Efficacy;Treatment outcome;treatment program;United States Department of Veterans Affairs;Veterans;Woman;Writing

PROJECT_TITLE: Written Exposure Therapy (WET) as a brief trauma treatment for Veterans with Co-occurring Substance Use Disorders and PTSD


FUNDING_MECHANISM: OTHERS

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Veterans have increased rates of frailty and fracture-related mortality when compared to the non- Veteran population. Rheumatoid arthritis (RA) is a risk factor for both osteoporosis and early- onset frailty. It is unknown whether frailty is an important risk factor for osteoporosis and fractures in Veterans with RA. With the aging US population and >10 million Veterans over the age of 60, it is imperative to improve the management of frailty and osteoporosis especially in high-risk groups, such as those with RA. Using data from both a local Veteran cohort and a national VA RA registry, this project will quantify the impact of frailty on osteoporosis and fractures as well as identify biomarkers that may predict the onset of frailty. Results from this study will set the foundation for future studies aimed at improving frailty and physical function thereby preventing osteoporosis and fractures in Veterans with RA.

PI_NAMEs: WYSHAM, KATHERINE D (contact)

PROJECT_TERMS: Acute;Address;Age;Aging;arthritis registry;Award;Biological Markers;Biology;biomarker identification;Bone Density;bone loss;career;Caring;Characteristics;Chronic;Clinical;Clinical Investigator;Clinical Trials;clinically relevant;cohort;comorbidity;Data;Data Analyses;Data Collection;Databases;Development;disability;Disease;early onset;Electronic Health Record;Excess Mortality;experience;Fall prevention;follow-up;Foundations;Fracture;frailty;Future;General Population;Goals;Healthcare Systems;high risk;high risk population;hip bone;Hip Fractures;Hospitalization;improved;indexing;Inflammation;Inflammatory;inflammatory marker;insight;Interleukin-1;Interleukin-6;Intervention;Measurement;Measures;Mentors;mortality;novel strategies;Osteoporosis;Osteoporosis prevention;osteoporosis with pathological fracture;Osteoporotic;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physical Function;Physicians;Physiological;Play;Population;predictive marker;predictive modeling;Predictive Value;premature;prevent;Prevention;Process;Quality of life;Reporting;Research;Research Design;Research Personnel;Rheumatism;Rheumatoid Arthritis;rheumatologist;Risk Factors;Role;Sampling;Scientist;Site;skills;sound;stressor;Syndrome;Techniques;TNF gene;Training;United States;United States Department of Veterans Affairs;Validation;Veterans;Veterans Health Administration

PROJECT_TITLE: Quantifying the Impact of Frailty on Osteoporosis and Fractures in Veterans with Rheumatoid Arthritis


ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: We will examine the association of hepcidin, a key iron regulator, with functional iron deficiency (FID) in chronic kidney disease (CKD) and determine if hepcidin and FID are associated with diabetic, kidney, and cardiovascular (CV) complications in people with CKD. If our study confirms the association between hepcidin and FID with increased clinical risk, it will (1) broaden our understanding of FID to include metabolic, renal, and CV consequences instead of the singular focus on anemia, (2) promote development of a therapeutic focus based on the underlying physiological mechanism of FID by targeting the hepcidin pathway rather than exclusively relying on anemia treatment with intravenous iron therapy, which is associated increased CV risk, and (3) provide evidence to support the development of clinical trials to evaluate safety and efficacy of anti- hepcidin therapy, which is already in development for treatment of anemia, for the expanded clinical indications of ameliorating renal, diabetic, and CV risks in CKD.

PI_NAMEs: CHO, MONIQUE EUN HEE (contact)

PROJECT_TERMS: accurate diagnosis;Address;Anemia;Anemia due to Chronic Disorder;Biological Assay;Cardiovascular Diseases;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Cell Physiology;cell type;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;clinical development;clinical investigation;clinical risk;Clinical Trials;cofactor;cohort;Data;Development;Diabetes Mellitus;diabetes risk;diabetic;Diabetic Nephropathy;Dialysis procedure;Disease;Disease Management;DNA;End stage renal failure;Energy Metabolism;Erythroid;Erythropoiesis;Event;Failure;Ferritin;Future;General Population;Goals;Health;Heart;Heart failure;Hematopoietic;Hemoglobin;Hepatic;hepcidin;Homeostasis;improved;indexing;Inflammatory;Informatics;Infrastructure;innovation;Insulin Resistance;Intravenous;Iron;iron absorption;iron deficiency;Iron Metabolism Disorders;Joints;Kidney;Knowledge;Longitudinal, observational study;Measures;Mediating;Metabolic;Metabolic Diseases;Mitochondria;modifiable risk;mortality;mortality risk;Muscle;Muscle Mitochondria;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Oral;Organ;Organ failure;Outcome;oxidation;Pathogenesis;Pathway interactions;Patients;Persons;Physiological;Plasma;Play;Population;prevent;Prospective cohort;Respiration;Risk;Risk Factors;risk stratification;Role;Safety;Serum;Signal Transduction;Therapeutic;therapeutic target;therapy development;Tissues;Transferrin;United States Department of Veterans Affairs;uptake;Veterans

PROJECT_TITLE: The role of functional iron deficiency in systemic complications of CKD

STUDY_SECTION: EPID

STUDY_SECTION_NAME: Epidemiology[EPID]


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: The research in this VA Merit Award will examine the impact of intermittent fasting to promote long term body weight maintenance following successful weight loss in overweight and obese Veterans. This research is especially relevant to the majority of Veterans who struggle with obesity and maintaining weight loss. Obesity increases the risk for storing excess calories in ectopic depots, including skeletal muscle. Intramuscular fat is related to altered substrate utilization (metabolic inflexibility) and defects in insulin sensitivity, ultimately leading to type 2 diabetes mellitus and cardiovascular disease. The identification of intermittent fasting as an alternative method to traditional weight maintenance protocols could have a significant impact on preventing body weight regain common after successful weight loss, and potentially lead to a reduction in pharmaceutical and clinical costs related to the care of overweight and obese Veterans.

PI_NAMEs: ORTMEYER, HEIDI K;RYAN, ALICE S. (contact);SERRA, MONICA C

PROJECT_TERMS: Abdomen;Adopted;Adoption;Aging;Animal Model;Award;Baltimore;Body Weight;Body Weight Changes;Body Weight decreased;Calories;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Clinical;clinical care;Clinical Trials;clinically significant;combat;comparison control;cost;Defect;Diabetes Mellitus;diabetes risk;Diet;diet and exercise;dietary approach;Dietary intake;effectiveness clinical trial;energy balance;Energy Intake;Energy Metabolism;Enrollment;Enzymes;evidence based guidelines;Exercise;Expenditure;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;flexibility;follow-up;Functional disorder;Gene Expression;Goals;good diet;Guidelines;Health;Health Benefit;Healthcare;healthy lifestyle;healthy weight;Heart;Human;Hypertension;impaired glucose tolerance;Impairment;improved;Individual;Inflammation;innovation;Insulin Resistance;insulin sensitivity;Intermittent fasting;Intervention;Intramuscular;Knowledge;Lipids;lipoprotein lipase;Long-Term Effects;Maintenance;Metabolic;Methods;military veteran;Mitochondria;mitochondrial dysfunction;Mobility decline;Morbidity - disease rate;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity management;Overweight;oxidation;Pharmacologic Substance;Phase;Physical activity;Physical Function;Play;Population;prevent;Prevention;primary outcome;Production;programs;Protocols documentation;Randomized;randomized, clinical trials;Recommendation;Relapse;Research;Risk;Risk Factors;risk minimization;Role;sedentary lifestyle;Skeletal Muscle;Stimulus;Testing;trend;United States Department of Veterans Affairs;Veterans;Weight;weight loss program;weight maintenance;Weight maintenance regimen;Woman

PROJECT_TITLE: Promotion of Successful Weight Management in Overweight and Obese Veterans


ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The prevalence of Parkinson’s disease (PD) and Traumatic Brain Injury (TBI) has increased significantly in military populations, with both of these conditions imposing a heavy health burden on Veterans and the VA Healthcare System. Cognitive impairment, neuropsychiatric symptoms, and poor quality of life (QoL) are common in Veterans who have either PD or a history of mild-moderate TBI, yet the impact of comorbid PD+TBI on these symptoms remains unclear. Preliminary evidence suggests that individuals with PD+TBI have poorer outcomes and reduced brain volume compared to PD patients without TBI. However, a comprehensive and systematic study of mild-moderate TBI impact on neuropsychological outcomes, QoL, and brain morphometry in Veterans with PD is needed. Such knowledge will greatly advance our understanding of the interaction between PD and TBI neuropathologies. Findings from this study have the potential to improve the identification, treatment, and management of at-risk Veterans with PD and/or TBI.

PI_NAMEs: SCHIEHSER, DAWN M. (contact)

PROJECT_TERMS: Anxiety;Attention;Biological Markers;Brain;Brain region;Brain Stem;brain volume;Caring;Chronic;Clinical;clinical practice;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Color;Communities;comorbidity;Data;Data Set;Development;Diagnosis;disability;Disabling;disorder risk;Enrollment;Ensure;Equipment and supply inventories;Executive Dysfunction;executive function;experience;follow-up;frontal lobe;gray matter;Health;Healthcare Systems;Hospitals;Impaired cognition;Impairment;improved;Incidence;Individual;Injury;interest;Knowledge;Linear Regressions;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediator;Medical;Memory;Mental Depression;mild traumatic brain injury;Military Personnel;Modeling;morphometry;Motor;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;MRI Scans;Nature;Neurodegenerative Disorders;neuroimaging;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neuropsychological Tests;Neuropsychology;non-demented;non-motor symptom;Outcome;Parkinson Disease;Participant;Patients;Persons;Pilot Projects;Play;Post-Traumatic Stress Disorders;Prevalence;primary outcome;Quality of life;Recording of previous events;recruit;Regression Analysis;Research;Risk;Risk Factors;Role;Sample Size;Sampling;Severities;Standardization;Symptoms;TBI Patients;Testing;Time;Traumatic Brain Injury;United States;Veterans;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Traumatic Brain Injury in Parkinson’s Disease: A Longitudinal Study


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Prostate cancer (PC) is a major cause of cancer incidence and mortality in US men. This year alone 230,000 men will be diagnosed and 30,000 will die of the disease; and worldwide, the annual number of men dying from PC is increasing. This highlights the urgent need for translational PC research to uncover the underlying genetic and genomic factors and pathways – including environmental and social contributions - that drive PC toward its lethal phenotype.

PI_NAMEs: NELSON, PETER S (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;anti-cancer research;Basic Science;Bioinformatics;Biology;Biometry;Biotechnology;British Columbia;Cancer Center;Cancer Etiology;Cancer Research Project;CAR T cell therapy;career;career development;Clinical;clinical development;Clinical Research;Clinical Sciences;Clinical Trials;Creativeness;Dedications;Development;Diagnosis;Diagnostic Procedure;Disease;DNA Repair;Effectiveness;Effectiveness of Interventions;effectiveness testing;Environment;Environmental Risk Factor;General Hospitals;Genetic;Genomics;Goals;Grant;Health;Heritability;Incidence;Individual;innovation;Institution;Laboratories;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methods;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;multidisciplinary;novel diagnostics;Oregon;Outcome;Output;Pacific Northwest;Pathology;Pathway interactions;Phenotype;Population Research;Population Sciences;Pre-Clinical Model;prevent;Prevention;programs;Prostate;prostate cancer progression;Protocols documentation;Quality of life;Receptor Signaling;Recording of previous events;Research;Research Personnel;resistance mechanism;response;Risk;Science;screening;Shapes;side effect;social;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;translational goal;tumor;Universities;Variant;Vision;Washington

PROJECT_TITLE: The Pacific Northwest Prostate Cancer SPORE


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Public Health Relevance The New York Regional Center for Diabetes Translation Research (NY-CDTR) has relevance to public health for three important reasons, the first being that much of our work is focused in the New York City metropolitan area, which is a population-dense, urban area with documented health and health care disparities for diabetes and obesity. Second, this region is home to various academic, health care system, public health resources, and community based organizations focused on health, thereby providing a strong platform for cutting-edge translational research; and third, the research base of the NY-CDTR is focused on diabetes translation research that can be sustainably implemented in diverse healthcare and community settings, and is designed to reach the underserved and disadvantaged.

PI_NAMEs: GONZALEZ, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Acceleration;Advocate;Area;Award;Awareness;base;Behavioral Sciences;biopsychosocial;career;career development;Clinical and Translational Science Awards;Collaborations;college;Communities;community organizations;community setting;community-centered;County;COVID-19;COVID-19 pandemic;design;diabetes control;Diabetes Mellitus;Diabetes prevention;Direct Costs;Disadvantaged;Disease Outbreaks;Educational workshop;Ensure;Environment;ethnic minority;ethnic minority population;experience;Extramural Activities;Faculty;Feasibility Studies;Fees;Fostering;Funding;Goals;Grant;Growth;Growth and Development function;Health;health care disparity;health care settings;health disparity;health equity;Health Resources;Health system;Healthcare Systems;Hispanic Community Health Study/Study of Latinos;Home;improved;innovation;Institution;Interdisciplinary Study;Intervention;Latino;Latino Population;Life Cycle Stages;life span;Low Income Population;Medicine;member;Mentors;Methodology;metropolitan;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;New York;New York City;Obesity;Outcome;patient oriented;Persons;Pilot Projects;podcast;Population;population health;Positioning Attribute;Prevention;Productivity;programs;Public Health;public health relevance;Publications;racial minority;racial minority population;Research;Research Personnel;Research Project Grants;resource guides;Resources;Services;social health determinants;socioeconomic disadvantage;Structure;success;symposium;Technology;Training;Training and Education;Translational Research;translational research program;United States National Institutes of Health;urban area;virtual;Vulnerable Populations;Work


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: Advocate;animal care;anti-cancer research;British Columbia;Cancer Center;cancer therapy;career;career development;Clinical;Communication;Consult;data dissemination;Development;Education;Equipment and Supplies;Faculty;faculty support;Funding;General Hospitals;Grant;Health;Healthcare Systems;human subject protection;innovation;Institution;Laboratories;Leadership;Link;Maintenance;Malignant neoplasm of prostate;meetings;National Cancer Institute;novel;Oregon;organizational structure;Pacific Northwest;Parents;patient engagement;Phase;Preparation;programs;Progress Reports;Prostate;Publications;Radiation;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Safety;Science;Scientist;Site;sound;translational cancer research;translational impact;Translational Research;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;virtual;Washington;web site;working group

PROJECT_TITLE: Core A: Leadership and Administrative