ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: OVERALL NARATIVE The overall goal of the UIC Maternal Health Research Center of Excellence is to advance maternal health research by examining the mechanisms by which structural racism contributes to maternal health disparities and develop innovative clinical practices to prevent maternal mortality (MM), reduce severe maternal morbidity (SMM), and promote maternal health equity in partnership with communities. The thematic focus is Synergize Multilevel Systems of Change for Maternal Health Equity. Our research projects explore novel mechanisms to improve maternal health outcomes by building on existing maternal health systems in new ways.

PI_NAMEs: CASKEY, RACHEL  (contact);GLASSGOW, ANNE ELIZABETH

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Affect;Area;Asian Americans;Behavioral;Biological;Birth;Black race;career development;Caring;Centers of Research Excellence;Chicago;cisgender;Cities;Clinical;clinical practice;Communities;community collaboration;community engagement;Community Health;community partners;community partnership;Country;Crime;Data;data repository;design;Development;Discipline;Disparity;Economically Deprived Population;Education;Environmental Risk Factor;ethnic minority;Exhibits;experience;Exposure to;Foundations;Gender;gender diverse;Generations;Goals;Health;health data;health disparity;health equity;Health equity research;health inequalities;Health Professional;Health system;Heart;Hispanic;Hispanic-serving Institution;Home;Illinois;Imprisonment;improved;improved outcome;Individual;Inequality;Inequity;Infrastructure;innovation;insight;Institution;interest;Intervention;Language;Life Cycle Stages;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;Mental Health;Minority-Serving Institution;Mission;Modeling;Native Americans;Neighborhoods;nonbinary;novel;Outcome;Pacific Island Americans;Persons;Population;Postdoctoral Fellow;postpartum care;Postpartum Women;Poverty;pre-doctoral;predictive modeling;prevent;prospective;queer;racial minority;repository;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Rural;Rural Community;Scholarship;Science;segregation;severe maternal morbidity;Site;Social Justice;sociocultural determinant;socioeconomic disadvantage;socioeconomic disparity;structural determinants;Structural Racism;Surveys;synergism;System;Training;transgender;Translations;Unemployment;Universities;Urban Community;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-F (71)]


ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: GLASSGOW, ANNE ELIZABETH (contact)

PROJECT_TERMS: Affect;Biological;Biology;Biophysics;black women;Centers of Research Excellence;Cessation of life;Characteristics;Chicago;Chronic;Chronic stress;Communities;community advisory board;community partnership;Crime;Data;Data Coordinating Center;data repository;Data Science;design;Disadvantaged;Disease susceptibility;Documentation;Epigenetic Process;epigenomics;Exhibits;experience;Exposure disparity;Exposure to;Family;Geographic Locations;Health;health disparity;Health equity research;health inequalities;Homicide;Illinois;Individual;Inequality;innovation;Insurance;Intervention Studies;Journals;Knowledge;Life Cycle Stages;Link;Lived experience;Maps;Maternal Health;Maternal health equity;Maternal Mortality;Measures;Medicaid;Mental disorders;metabolomics;Methods;Modeling;Molecular;Molecular Analysis;Molecular Profiling;mortality disparity;neighborhood association;Neighborhoods;Outcome;Overdose;Participant;Pathway interactions;Patients;Perception;Personal Satisfaction;Pharmaceutical Preparations;Play;Population Intervention;Postpartum Period;Postpartum Women;Poverty;Pregnancy;pregnancy related death;Pregnant Women;Privatization;prospective;Proteomics;Public Health;Qualitative Methods;Race;Research;residential segregation;Resources;Risk;Risk Factors;Role;Safety;segregation;severe maternal morbidity;social;Social Work;socioeconomic disadvantage;Structural Racism;Suicide;synergism;System;Training;Universities;Violence;Visual;Voice;White Women;Woman;Women's Health;Writing

PROJECT_TITLE: Multilevel exposure to adversity across the life-course: Quantifying biological implications in urban postpartum women


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Primary Health Care;Social Determinants of Health;Women's Health Research

PI_NAMEs: HAMLISH, TAMARA  (contact)

PROJECT_TERMS: Address;Age;Behavior;Benchmarking;Bilateral;care systems;Centers of Research Excellence;Chicago;Chronic Disease;Collaborations;Communities;community advisory board;community engagement;Community Health;community intervention;Community Networks;community organizations;Community Participation;community partners;community partnership;community-level factor;Coordination and Collaboration;design;Disparity;disparity elimination;dissemination strategy;economic value;Educational Status;Environment;Equity;Ethnic Origin;Exclusion;experience;Family;Goals;Government Agencies;Health;health care availability;health disparity;health inequalities;health outcome disparity;Health Personnel;Healthcare;Healthcare Systems;human centered design;Illinois;improved;Individual;Inequity;Insurance;Intervention;Knowledge;Life;Link;Local Government;Location;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;member;Mental Health;Mental Health Services;Outcome;Participant;Pathway interactions;Persons;Phase;Play;Policy Maker;Politics;primary care services;primary health service;Process;Provider;Race;recruit;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Subjects;residence;Resources;social;Social Network;social relationships;Structural Racism;Structure;substance use;synergism;System;Training;Training Activity;Trust

PROJECT_TITLE: Community Partnership Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

PI_NAMEs: HANDLER, ARDEN S (contact)

PROJECT_TERMS: Academic support;Address;Affect;Behavioral;Biological;Biological Factors;care delivery;career;career development;Centers of Research Excellence;Chicago;Clinical;clinical care;Communities;community engagement;community partners;Data Collection;Decision Making;Development;Disparity;Educational Curriculum;Environmental Risk Factor;Epidemiology;ethnic diversity;Etiology;evidence base;experience;Exposure to;Faculty;falls;Goals;health inequalities;Health Personnel;Illinois;implementation science;improved;Individual;Inequity;innovation;insight;interest;Intervention Studies;Knowledge;knowledge base;Maternal Health;Maternal Mortality;Mentors;Methods;mortality;multidisciplinary;novel;novel strategies;Outcome;Postdoctoral Fellow;Pregnancy;programs;Public Health;Qualitative Research;racial diversity;recruit;Research;Research Activity;Research Assistant;Research Methodology;Research Personnel;research to practice;Research Training;severe maternal morbidity;skills;sociocultural determinant;structural determinants;System;Training;Training Activity;Training Programs;Translating;Universities;Woman;women of color

PROJECT_TITLE: Training Core


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Veterans with opioid dependence or addiction (known as opioid use disorder or OUD) reduce their risk of adverse health outcomes, overdose, and death when they receive evidence-based treatments, including medication treatment (MOUD). VA has been successful in improving access to these treatments for all Veterans. However, many Veterans with OUD are not engaged in care (e.g., do not receive available treatment or discontinue treatment prematurely). Providing patient-centered care, or care that is specific to patient preferences, needs, and values of each Veteran, can improve engagement in care, but the extent to which this occurs in VA is not known. VA is committed to delivering patient-centered care. Key to fulfilling that commitment is Veteran patients’ involvement in defining how care should be delivered to meet their needs and in developing appropriate measures of patient-centered care to provide meaningful feedback to OUD clinicians and improve clinical performance. This study aims to improve patient-centered care for Veterans with OUD.

PI_NAMEs: KELLEY, ALAN TAYLOR (contact)

PROJECT_TERMS: Address;Adherence;Affect;Buprenorphine;care preference;care seeking;Caring;Cessation of life;Clinical;Collaborations;design;Disincentive;Disparity;Ensure;Equilibrium;Evidence based treatment;falls;Feedback;follow-up;Future;Goals;Health;health care availability;Health Services Accessibility;implementation strategy;Improve Access;improved;improved outcome;individual patient;Intervention;Interview;Investigator-Initiated Research;Measurement;Measures;Medical center;Morbidity - disease rate;mortality;novel strategies;Opiate Addiction;opioid use disorder;Outcome;Overdose;patient engagement;patient oriented;Patient Preferences;Patient-Centered Care;Patients;Performance;Pharmaceutical Preparations;Play;Population;preference;premature;Prevalence;Provider;Quality of Care;Recommendation;Recording of previous events;Research Personnel;Research Proposals;Risk;Role;Substance Use Disorder;Surveys;Techniques;theories;tool;treatment guidelines;treatment planning;Veterans;Visit;Voice;willingness;Work

PROJECT_TITLE: Patient-centered Quality Measurement for Opioid Use Disorder

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE To make an impact on the rising rates of suicide, we must improve the ability to predict when and for whom suicidal behavior will occur. This project overcomes the methodological limitations of prior studies of risk factors for suicidal thoughts and behaviors by studying a promising and clinically informative proximal risk factor for suicide (agitation) using mobile devices that provide high-resolution objective and subjective data, a high-risk sample (psychiatric inpatients), and a short period of high suicide risk (immediately following hospital discharge), and in combination with other distal and proximal risk factors. Findings will inform short-term suicide risk prediction and the development of novel just-in-time interventions for individuals at high risk of suicide.

PI_NAMEs: BENTLEY, KATE H. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accelerometer;Acute;Address;Admission activity;Adult;Agitation;American;Anxiety;Area;Arousal;Attention;Award;Behavioral;behavioral study;Biological Markers;career;Cause of Death;Cellular Phone;Cessation of life;Clinical;Clinical assessments;clinical biomarkers;Consensus;Data;Data Analyses;demographics;Development;Diagnosis;diaries;digital monitoring;Distal;DSM-V;Ecological momentary assessment;Feeling;Feeling suicidal;Foundations;Funding;Future;Grant;Guide prevention;handheld mobile device;high risk;Hospitalization;Hospitals;Hour;improved;Individual;Inpatients;Intervention;Jordan;Knowledge;Left;Machine Learning;Manuscripts;Maps;Massachusetts;Measures;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Motor Activity;multidisciplinary;multilevel analysis;National Institute of Mental Health;negative affect;novel;patient oriented research;Patient Self-Report;Patients;Positioning Attribute;predictive modeling;Prevention;Protocols documentation;psychiatric inpatient;Public Health;Public Health Schools;Publishing;Reporting;Research;Research Personnel;Resolution;Risk;Risk Assessment;Risk Factors;risk prediction;Role;Sampling;Self-Injurious Behavior;standard measure;substance use;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Technology;Testing;Time;Training;United States;United States National Institutes of Health;wearable sensor technology;Work;Wrist

PROJECT_TITLE: Digital Monitoring of Agitation for Short-Term Suicide Risk Prediction

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Extracellular stimuli such as, hormones, neurotransmitters and drugs, work by activating receptors to induce cell signaling which leads to physiological responses. The proposed project focuses on neuronal receptors, key drug targets for neuropsychiatry, that reside in specialized neuronal compartments, whose functions are unknown, called primary cilia. This proposal will examine three important questions (i) how different neuronal receptors are selected to be transported to primary cilia, (ii) how receptors signal in the cilium and (iii) what impact the signaling has on neuronal gene expression changes that influence neuronal function.

PI_NAMEs: EHRLICH, ALIZA TOBY (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affinity Chromatography;Behavioral;Biosensor;Brain;brain tissue;Carrier Proteins;Cell model;cell type;Cells;Cilia;ciliopathy;Cognitive;Collection;comparative;Corpus striatum structure;Coupled;Cyclic AMP;Cyclic AMP Receptors;Cyclic AMP-Dependent Protein Kinases;Data;Development;developmental disease;Disease;DNA Sequence Alteration;DRD2 gene;Drug Targeting;Environment;Event;experience;extracellular;Foundations;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genetic Transcription;Goals;GPER gene;GTP-Binding Protein alpha Subunits, Gs;Hormones;Human;Image;Impairment;improved;in vivo;Induced Neurons;Knock-in Mouse;Label;Location;Mass Spectrum Analysis;Mechanics;Mediating;Methods;Molecular;Morphology;mu opioid receptors;Mus;Nervous System Disorder;neural;Neuromodulator;neuronal cell body;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurotransmitters;novel;novel therapeutic intervention;Nuclear;Obesity;Organelles;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Population;Production;Proteins;Proteome;Proteomics;receptor;Receptor Activation;receptor function;Receptor Inhibition;Receptor Signaling;receptor-mediated signaling;Recombinants;Research Proposals;response;Second Messenger Systems;Signal Transduction;Signaling Protein;Small Interfering RNA;smoothened signaling pathway;Stimulus;Symptoms;System;Techniques;Testing;theories;Tissues;tool;Training;transcriptome sequencing;transmission process;Venus;Work

PROJECT_TITLE: Neuronal Gαi-GPCR targeting to primary cilia and impact on cAMP mediated transcription

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE The Louisiana-Arizona Nutrition for Precision Health Center (LAAZ-NPH), consisting of LSU-Pennington Biomedical in Baton Rouge, LSU-Health Sciences Center in New Orleans, and the NIDDK-Clinical Center in Phoenix aims to recruit participants from the All of Us research program into the three proposed modules of the NPH consortium with an emphasis on minorities, including African American, Hispanic, and Native American populations. In Module 1 (n=2,000), we will carefully catalogue habitual dietary intake and measure the post- prandial glucose response (PPGR) to a standard mixed meal tolerance test (MMTT) and collect baseline measures of health, behavior and environment. The same MMTT will be used to compare the PPGR and inter- individual variability to three distinct eucaloric diets, each eaten for 2-weeks in a crossover randomized order: a hybrid Mediterranean-DASH diet (MEDASH); the sustainable and predominantly plant-based Flexitarian diet (FLEX); and the ubiquitously available Highly Preferred Western Diet (HPWD) to both free-living (Module 2, n=300) and domiciled (Module 3, n≥100) individuals.

PI_NAMEs: RAVUSSIN, ERIC  (contact);REDMAN, LEANNE MAREE

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;African American;All of Us Research Program;Area Under Curve;Arizona;Behavior;Behavioral;Biological;Biological Markers;Blood;Cardiometabolic Disease;cardiometabolism;Catalogs;Chronic Disease;clinical center;Clinical Nutrition;Clinical Research;cognitive function;Collaborations;Collection;Complex;Continuous Glucose Monitor;Cross-Over Studies;DASH diet;Data;Data Set;Databases;design;Diet;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;Disease;Domiciles;doubly-labeled water;Eating;Effectiveness;Eligibility Determination;Enrollment;Environment;ethnic diversity;experience;Fatty acid glycerol esters;Feces;feeding;Food;Genetic;Glucose;Goals;gut microbiota;Hair;Health;health disparity;Health Promotion;Health Sciences;Heterogeneity;Hispanic Americans;Human;Hybrids;Individual;individual response;innovation;Inpatients;Insulin Resistance;inter-individual variation;Investigation;Louisiana;machine learning algorithm;Measures;Mediterranean Diet;Metabolic;Metabolic syndrome;Metabolism;microbiome;Minority;Modernization;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;Native American population;novel;nutrition;Observational Study;Outpatients;Participant;participant retention;Patient Recruitments;Pattern;personalized nutrition;Phenotype;Photography;Physical activity;Physiology;Plants;Plasma;Population;Population Heterogeneity;Positioning Attribute;Precision Health;precision nutrition;prediction algorithm;primary endpoint;prospective;Proteins;Protocols documentation;Randomized;randomized trial;recruit;Research;Research Design;Research Personnel;response;retention rate;Saliva;Sampling;secondary endpoint;Site;Specific qualifier value;stable isotope;Standardization;Testing;Urine;wearable device;western diet

PROJECT_TITLE: The Louisiana Clinical Center of Nutrition for Precision Health (LA-NPH)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Sleep Research

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Although research on implementation of evidence-based treatments (EBTs) in community settings has advanced rapidly, research on sustainability of those EBTs is alarming limited. Using mixed methods, hierarchical linear modeling, and structural equation modeling, this study will evaluate predictors, mechanisms, and outcomes of sustainability of an EBT delivered to patients with serious mental illness and sleep and circadian dysfunction in 10 community mental health centers. In line with the NIMH’s Strategic Plan 4.2, the knowledge gained from this F32 will advance the field’s limited research on sustainability of EBTs in community settings, thereby improving the long-term effectiveness of existing mental health services.

PI_NAMEs: SARFAN, LAUREL D (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Automobile Driving;bone;California;career;Circadian Dysregulation;Communities;Community Mental Health Centers;community setting;Complex;design;Diagnostic;Effectiveness;Environment;Equation;Evaluation;Evidence based treatment;Fellowship;Goals;implementation barriers;implementation framework;implementation intervention;implementation outcomes;implementation science;improved;Individual;Infrastructure;Intervention;Interview;Investigational Therapies;Knowledge;Linear Models;Measures;Mediating;Mediation;Mediator;Mental Health;Mental Health Services;Mentorship;Methods;Modeling;National Institute of Mental Health;Outcome;Parents;Patient-Focused Outcomes;Patients;Perception;Phase;post implementation;practice setting;prevent;programs;Provider;Questionnaires;Randomized;recruit;Research;Research Design;Research Personnel;Resources;response;routine practice;severe mental illness;Sleep Disorders;Strategic Planning;Structure;sustainability framework;Testing;theories;Training;training opportunity;United States National Institutes of Health;Universities

PROJECT_TITLE: Advancing Sustainability of Evidence-Based Treatments in Community Mental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Developmental dyslexia is a deficit in accurate or fluent word reading typically associated with deficits in sound processing affecting 5-12% of all school-aged children. Neuroimaging research into sound processing in dyslexia has greatly informed our understanding of dyslexia and its treatment; however, much less is known about how individuals with dyslexia process units of meaning. Using a combination of neuroimaging and behavioral methods, the proposed project will investigate morphological processing in a sample of child readers with and without dyslexia, potentially informing both literacy theory and research-based educational practices for struggling readers.

PI_NAMEs: MARKS, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;Age;age difference;Age Distribution;age effect;Articulation Disorders;Awareness;Behavior;behavior measurement;Behavioral;behavioral study;Brain;Child;Childhood;clinical practice;cognitive skill;Communities;Compensation;Data;Development;Developmental reading disorder;Dissociation;Dyslexia;Educational Models;elementary school;experience;Fellowship;fifth grade;Foundations;Functional Magnetic Resonance Imaging;Goals;Grain;Impairment;improved;Individual;Inferior;Intervention;junior high school;Knowledge;Language;Learning Disabilities;lexical;literacy;longitudinal analysis;Measures;Methodology;Methods;Modeling;Morphology;Multivariate Analysis;neural;neural correlate;Neurocognitive;neuroimaging;novel;Oral;Orthography;Outcome;Parietal;Participant;peer;phonological awareness;phonology;Printing;Process;Reader;Reading;reading comprehension;reading difficulties;Reading Disabilities;recruit;Reporting;Research;Resources;Role;Sampling;School-Age Population;skills;sound;Standardization;success;Teaching Method;Testing;Theoretical model;theories;third grade;Time;Training;Visual;Work

PROJECT_TITLE: Neurocognitive Foundations of Morphological Processing in Children with Dyslexia


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Precision Medicine;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There is no best diet to optimize health in everyone. This project will identify reasons why different people respond differently to different dietary patterns. This can lead to an ability to prescribe individuals or groups of individuals with diets that best promote health and wellness.

PI_NAMEs: GOWER, BARBARA A;HILL, JAMES O (contact)

PROJECT_TERMS: Affect;African American population;Alabama;Algorithms;Artificial Intelligence;Behavior;Behavioral;Bioinformatics;Biopsy;Blood Pressure;Body Composition;Calorimetry;cardiorespiratory fitness;Cardiovascular Diseases;Chronic Disease;clinical center;Clinical Research;Clinical Sciences;Cognitive;Complex;Consumption;Crossover Design;Data;Data Analyses;data repository;Databases;design;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Dietary Practices;Domiciles;doubly-labeled water;eHealth;Energy Metabolism;Environment;Environmental Exposure;Environmental Risk Factor;Exercise;experience;Fatty acid glycerol esters;feeding;fitness;Foundations;Genetic;genetic makeup;Genomics;Glucose;Goals;Health;Health Promotion;Hour;Hypertension;Individual;individual variation;Infrastructure;Intervention;Letters;Machine Learning;Macronutrients Nutrition;Maintenance;Malignant Neoplasms;mathematical model;Measurement;Measures;Medicine;member;Metabolic;Metabolism;metabolomics;Metadata;Methods;microbiome;Modeling;Movement;multimodal data;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrition;Obesity;Observational Study;Outcome;Participant;Personal Satisfaction;Persons;Phenotype;Physical activity;Physiological;Population;Population Heterogeneity;Positioning Attribute;Precision Health;precision nutrition;predicting response;predictive tools;prevent;Psychosocial Factor;Randomized;recruit;Research;Resources;response;Site;Sleep;Standardization;Surveys;Testing;Translational Research;Universities

PROJECT_TITLE: UAB Precision Nutrition Clinical Center


ADMINISTERING_IC: AA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Nutrition;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) represents a leading contributor to premature death and global disease burden. Altered brain metabolism in AUD may contribute to symptoms of withdrawal following cessation of alcohol use. The proposed study will formalize a mediation model to explain the relationship between brain metabolism, neural circuitry, and alcohol craving during withdrawal, which will aid the development of personalized treatment approaches to mitigate relapse liability.

PI_NAMEs: BRYNILDSEN, JULIA KATHERINE (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acetates;Alcohol consumption;alcohol craving;alcohol cue;Alcohol dependence;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;American diet;Amino Acids;Anterior;Automobile Driving;Behavior;behavior measurement;Behavior Therapy;Bioenergetics;Brain;brain control;brain metabolism;Brain region;burden of illness;Cessation of life;Chronic;chronic alcohol ingestion;cingulate cortex;Cognition;Cognitive;cognitive reappraisal;control theory;craving;cue reactivity;Cues;deprivation;Development;Diet Modification;Dopamine;Dorsal;drinking;Drug Metabolic Detoxication;functional MRI scan;gamma-Aminobutyric Acid;glucose metabolism;Glutamates;Glutamine;Goals;Homeostasis;Individual;insight;Intervention;ketogenic diet;ketogentic;Magnetic Resonance Spectroscopy;Maintenance;Measures;Mediation;Mental disorders;Metabolic;Metabolic Control;Metabolism;Mission;Modeling;multimodal data;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;neuromechanism;Neurotransmitters;novel therapeutic intervention;Participant;Patients;personalized medicine;Persons;Population;premature;Reaction;Relapse;Research;response;Rewards;Role;Scanning;Specific qualifier value;Structure;System;Testing;therapeutic development;Time;tool;United States;Ventral Striatum;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Metabolic control of cue reactivity during alcohol withdrawal


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Stress exposure has been found to be a strong predictor of young adults' alcohol use, yet effects from stress exposure through digital means on alcohol use are unknown. The proposed project uses novel methodology involving participant-uploaded screenshots of digital stressors in a daily diary study from young adults in romantic relationships from the beginning of the COVID-19 pandemic, providing a wealth of subjective and objective data on uncontrollable stressors, such as the pandemic, racial injustices, and civil unrest. By examining how digital stressors influence same- and next-day alcohol use, this research will identify potential intervention points informing prevention and intervention efforts to reduce the impact of stress exposure through technology on young adult alcohol use.

PI_NAMEs: QUIROZ, SELENA  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Adult;Affect;age group;Alcohol abuse;Alcohol consumption;alcohol use disorder;Anxiety;Area;Attention;Cellular Phone;Code;contagion;Couples;COVID-19 pandemic;COVID-19 stress;Data;Data Analyses;Data Collection;Depersonalization;desensitization;Development;Devices;diaries;digital;digital data;Distress;drinking;Equipment and supply inventories;Ethics;Event;experience;Exposure to;Fellowship;Future;Generations;handheld mobile device;Hispanic;improved;Individual;Intervention;intervention program;Knowledge;Life;Link;Measures;Mentorship;Methodology;Methods;Modeling;Natural Disasters;news;novel;pandemic disease;Participant;Patient Self-Report;Persons;Post-Traumatic Stress Disorders;prevent;Prevention;Probability;Racial injustice;Randomized;reduced alcohol use;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Risk;Sampling;Severities;skills;Social Environment;social media;Stress;Stressful Event;stressor;Students;success;Symptoms;Technology;Terrorism;Text Messaging;theories;Time;Training;transmission process;Trauma;Writing;young adult;young adult alcohol use

PROJECT_TITLE: Daily Impact of Stressful Digital Events During the COVID-19 Pandemic on Alcohol Use Among Young Adults in Romantic Relationships


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunotherapy;Infectious Diseases;Kidney Disease;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Although new therapies focusing on blocking the activation of a specific type of lymphocyte, CD8+ T cells, show promise in renal transplantation, what these CD8+ T cells specifically react to remain poorly defined. This proposal aims to identify and characterize the unique CD8+ T cells driving renal transplant rejection. Deeper understanding of what these specific CD8+ T cells react to will uncover new knowledge critical to identification of pathways used by these cells and development of new anti-rejection therapeutics.

PI_NAMEs: SHI, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Affect;Alloantigen;Allogenic;allograft rejection;Allograft Tolerance;Allografting;Alpha Cell;Anti-CD40;Autoimmunity;Automobile Driving;Biology;Biopsy;Blood;CD8-Positive T-Lymphocytes;Cell Therapy;Cells;Chronic;Clonal Expansion;Clone Cells;combat;Cross Reactions;cross reactivity;CTLA4-Ig;Cytomegalovirus;Data;Development;Diabetes Mellitus;Disease;Effectiveness;End stage renal failure;Event;experimental study;Frequencies;Gene Expression;Gene Expression Profile;Goals;graft failure;graft function;Graft Rejection;Hand;Health;heart allograft;Home;Human;human disease;Human Herpesvirus 4;Hypertension;Immunity;Immunobiology;Immunosuppression;Individual;Infection;Infection Control;Infiltration;insight;Jurkat Cells;kidney allograft;Kidney Transplantation;Knowledge;Life Expectancy;Link;Literature;Lymphocyte;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Memory;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;new therapeutic target;novel;novel therapeutics;Organ;Organ Transplantation;Pathway interactions;Patients;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Play;post-transplant;premature;prevent;Quality of life;Reaction;response;Risk;Role;Sampling;screening;single cell analysis;single-cell RNA sequencing;Solid;Specificity;standard of care;T cell infiltration;T cell receptor repertoire sequencing;T cell therapy;T memory cell;T-Lymphocyte;Tacrolimus;Testing;Therapeutic;Therapeutic immunosuppression;Time;Toxic effect;transcriptomics;transplant model;Transplant Recipients;Transplantation;Urine;Viral;Viral Antigens;Virus Diseases;Work

PROJECT_TITLE: Single Cell Analysis of Alloreactive CD8+ T Cells in Kidney Transplant Rejection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Lymphatic Research;Lymphedema;Regenerative Medicine

PHR: PROJECT NARRATIVE Secondary lymphedema following cancer surgery and treatment remains a challenging disease due to the reduced limb function, increased risk of deadly infections and the lack of curative treatment. Currently, it is not known whether large lymphatic vessels can repair, regenerate or remodel post-surgery. Understanding the process by which lymphatic vessels regrow and remodel is essential to recreate/repair damaged lymphatic structures. If successful, this proposal will provide a mechanistic understanding of lymphatic growth and remodeling, thereby providing insight into better surgical interventions and novel therapeutic strategies to prevent or reverse lymphedema.

PI_NAMEs: RAZAVI RIZI, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Accidents;Acute;Adult;Alleles;angiogenesis;Animal Model;Antibodies;Antineoplastic Agents;Axillary lymph node group;Biology;Biomedical Engineering;Bypass;cancer surgery;cancer therapy;Cannulations;Cardiovascular Diseases;Cell Culture System;Cells;Complement;Complex;Computer Models;Cultured Cells;curative treatments;density;Diameter;Disease;Distal;Drainage procedure;Endothelium;Environment;Excision;Experimental Models;experimental study;Exposure to;Extracellular Matrix;Functional disorder;Genetic;Goals;Growth;Histology;Hydrogels;Image;image processing;Imaging Device;Impairment;In Vitro;in vitro Model;Infection;inhibitor;Injury;insight;Intercellular Fluid;intravital microscopy;Label;Length;Ligands;Ligation;Limb structure;Liquid substance;lymph flow;lymph node biopsy;Lymph Node Dissections;lymph nodes;Lymphatic;lymphatic circulation;Lymphatic Diseases;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;lymphatic imaging;Lymphatic Obstruction;Lymphatic Research;Lymphatic System;lymphatic vessel;Lymphedema;Maintenance;Malignant Neoplasms;Measures;Mediating;Microfluidics;migration;Modeling;mouse model;Mus;Muscle Cells;Natural regeneration;Near-infrared optical imaging;novel therapeutic intervention;Operative Surgical Procedures;Optical Coherence Tomography;Organ;Pathway interactions;Patients;Pharmacotherapy;Phenotype;Phosphorylation;Play;Postdoctoral Fellow;pressure;Prevalence;prevent;Prevention strategy;Process;Pump;Radiation therapy;repaired;Reporting;response;Risk;Role;Route;secondary lymphedema;shear stress;Signal Pathway;Signal Transduction;Site;Structure;Surgeon;System;Testing;Therapeutic Intervention;three dimensional cell culture;tool;Training;Trauma;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular Endothelial Growth Factor Receptor-3;Western Blotting

PROJECT_TITLE: Regeneration and remodeling of collecting lymphatic vessels post-injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  LGBTQ people of color (LGBTQ-POC) disproportionally experience the cumulative stress of systemic inequal- ity and discrimination and are especially vulnerable to adverse mental health outcomes such as depression and suicide-related behaviors. Despite these unique challenges, the literature has failed to address the longitudinal trajectories of mental health outcomes from a developmental perspective due to limited sample sizes and multiple methodological limitations. The proposed project fills an important gap in the literature by using Integrative Data Analysis to examine a large developmental period to provide insight into the mechanisms that contribute to the increased rates of depression and suicidality among LGBTQ-POC.

PI_NAMEs: VALIDO DELGADO, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: 19 year old;Address;Adolescent;Adult;adverse childhood events;African American;Age;Area;associated symptom;base;Behavior;Black race;career;Childhood;Clinical;clinical practice;cohort;Crime;critical period;Data;Data Analyses;Data Set;depressive symptoms;design;Development;Discrimination;Early identification;Enrollment;ethnic identity;Exclusion;experience;Exposure to;Extramural Activities;Family;family support;Feeling suicidal;Fellowship;Frequencies;Funding;Future;Gender Identity;Goals;Growth;Health;Health Professional;Health Resources;improved;Individual;Inequality;insight;Intervention;Latinx;Length;Lesbian Gay Bisexual Transgender Queer;life span;Literature;Longitudinal Studies;low socioeconomic status;marginalization;Mental Depression;mental development;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;minority children;Modeling;multi-racial;National Institute of Mental Health;Neighborhoods;next generation;Outcome;Participant;Pattern;people of color;Personal Satisfaction;Prevention;prevention practice;Prevention trial;preventive intervention;protective factors;Public Health;racial identity;Randomized;Records;remediation;Research;Research Personnel;Risk;Sample Size;Sampling;Science;Secure;sexual identity;Signal Transduction;Source;Stress;Subgroup;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Surveys;Symptoms;Techniques;Therapeutic Intervention;tool;Training;Training Programs;Trust;Universities;Youth

PROJECT_TITLE: Developmental trajectories of depression and suicide among LGBTQ people of color: An Integrative Data Analysis of 18 prevention trials.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative The goal of this study is to reveal a novel lncRNA-responsive and xenobiotic receptor-mediated regulation of drug metabolism and disposition. Specifically, we propose to test the hypothesis that a group of novel lncRNAs, identified by our computational analysis and experimental validation, can affect chemo-resistance through their regulation of drug-metabolizing enzymes and transporters that are responsible for the metabolism and disposition of chemotherapy drugs. Understanding the novel lncRNA responsive and xenobiotic nuclear receptor-mediated chemo-resistance will help provide novel strategies to enhance therapeutic efficacy and avoid the development of chemo-resistance.

PI_NAMEs: YANG, DA  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: absorption;Affect;Bioinformatics;Biological Assay;Biological Process;Breast Cancer Cell;cancer cell;Cancer Cell Growth Regulation;Cancer cell line;Cancer Patient;cancer therapy;cancer type;Cell Physiology;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;ChIP-seq;Clinical;Clinical Management;clinical prognosis;Code;Computer Analysis;constitutive androstane receptor;crosslinking and immunoprecipitation sequencing;Data;Databases;Development;Dimensions;docetaxel;Doxorubicin;drug disposition;Drug Efflux;Drug Interactions;drug metabolism;Drug Regulations;Drug Screening;Enzymes;Evolution;Excretory function;gain of function;Genes;Genetic Transcription;Genomics;Genotype;Goals;Immunoprecipitation;In Vitro;in vivo;knock-down;Length;Location;Luciferases;Machine Learning;machine learning model;Malignant Neoplasms;Mediating;Medical;Metabolism;Modeling;Molecular Cloning;novel;novel strategies;Nuclear Receptors;Nucleotides;Outcome;overexpression;Pharmaceutical Preparations;Pharmacogenomics;pharmacokinetics and pharmacodynamics;pregnane X receptor;Primary Neoplasm;Proteins;receptor;Regulation;Reporter Genes;Research;Resistance;Resistance development;response;RNA;RNA-Protein Interaction;Sampling;Specificity;Technology;Testing;Tissues;Transcriptional Regulation;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;Untranslated RNA;Up-Regulation;uptake;Validation;Xenobiotics

PROJECT_TITLE: A novel lncRNA-responsive and xenobiotic receptor-mediated regulation of drug metabolism and disposition

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative: The inflammatory response has evolved to provide defense and protection by means of fighting infectious pathogens and healing wounds. However, uncontrolled or unresolved inflammation can conversely yield deleterious damage to tissue and disease. I endeavor to interrogate molecular mechanisms within the inflammatory response, focusing on leukocyte transmigration, to identify potential targets for forthcoming anti- inflammatory treatment.

PI_NAMEs: CLEVENGER, MARGARETTE HELEN (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Academia;Acute;Address;Affect;Air;Anti-Inflammatory Agents;Area;Atherosclerosis;Biological Assay;Blood Vessels;Body System;career;CD31 Antigens;Cell Adhesion Molecules;Cell Line;cell motility;cell type;Cells;Chronic;chronic inflammatory disease;Circulation;clinical application;combat;comorbidity;Compensation;Confocal Microscopy;Data;Disease;Endothelial Cells;Endothelium;Event;experience;fighting;Flow Cytometry;Gene Expression Profile;Goals;In Vitro;in vitro Model;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;intravital microscopy;Ischemia;Kinesin;Knock-out;Lateral;Learning;Left;Leukocyte Adhesion Molecules;Leukocytes;Lymphocyte;Mediating;Membrane;Membrane Protein Traffic;Methods;Microtubules;migration;Migration Assay;Modeling;Molecular;monocyte;mouse model;Movement;Mus;Myocardial Infarction;neutrophil;pathogen;Pathologic;Pathology;Pathway interactions;PECAM1 gene;Phase;Phenotype;Population;Process;Property;receptor;recruit;Recycling;Refractory;Reperfusion Injury;Research;Research Personnel;Residual state;Resistance;response;Role;screening;Signal Pathway;Signal Transduction;Site;Stimulus;Stroke;Structure;Surface;Therapeutic;Time;tissue repair;Tissues;trafficking;transcriptome sequencing;Tubular formation;Vasculitis;wound healing

PROJECT_TITLE: Alternative Mechanisms of Monocyte Transendothelial Migration in Inflammation


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative We will determine whether abnormalities in a key population of circulating blood cells called monocytes affects the very early outcomes of lung transplants in patients with severe lung diseases. We will assess whether problems with monocytes can be detected pre-transplant using blood samples already being collected as part of an NIH-funded clinical study of lung transplant recipients. Our studies may identify new diagnostic or therapeutic options to decrease the high morbidity and mortality rates currently associated with clinical lung transplantation.

PI_NAMEs: HANCOCK, WAYNE WILLIAM (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Acute Lung Injury;adaptive immunity;Adult;Affect;Binding;Biological Markers;biomarker validation;Blood Cells;Blood specimen;Blood Vessels;CD14 gene;Cell surface;Cells;Characteristics;Chronic lung disease;Clinical;Clinical Research;Collaborations;cytokine;Data;Deacetylase;Death Rate;Development;Disease;Disease susceptibility;Engineering;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Event;Flow Cytometry;Functional disorder;Funding;Gene Expression;Genetic Transcription;Genetic Variation;genomic locus;graft dysfunction;HDAC6 gene;Histones;Hour;Hypoxemia;Immune;Immunity;Immunologics;In Vitro;in vivo;individual variation;Inflammatory;Infrastructure;inhibitor;inhibitor therapy;Injury;Ischemia;Longterm Follow-up;Lung;Lung Diseases;lung ischemia;Lung Transplantation;Messenger RNA;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;novel;novel diagnostics;novel therapeutics;Operative Surgical Procedures;Outcome;overexpression;Parents;participant enrollment;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Population;Postoperative Period;predicting response;Process;Production;prognostic;Proteins;Publishing;Pulmonary Edema;Regulation;Reperfusion Injury;Research;Research Personnel;response;Risk;Risk Factors;Role;Sample Size;small molecule inhibitor;Source;Testing;Therapeutic;TLR4 gene;Training;transcriptome;transcriptome sequencing;translational study;Transplant Recipients;Transplantation;treatment response;Ubiquitin;United States National Institutes of Health;Up-Regulation;Zinc Fingers

PROJECT_TITLE: Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Centrosome dysfunction leads to a variety of human disorders such as cancer, microcephaly, dwarﬁsm, and diseases caused by defects in cilia including Down syndrome. The project will provide insights into how the centrosome is assembled and functions, especially during cell division. Detailed investigation of this process will provide fundamental knowledge and may inform potential therapeutic strategies for many diseases associated with dysfunction of centrosome and cilia.

PI_NAMEs: JAO, LI-EN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Animals;Biochemical;Biological;Cell division;Cells;Centrioles;Centrosome;Characteristics;Chromosome Segregation;Cilia;Clinical;Crowding;Cytoplasmic Granules;Data;Defect;developmental disease;Disease;Down's Syndrome;Dwarfism;Dynein ATPase;Embryo;Ensure;Functional disorder;G2/M Transition;Genetic;Glues;Goals;Human;human disease;Imaging Techniques;In Vitro;insight;Investigation;Knowledge;Light;link protein;Liquid substance;loss of function mutation;Malignant Neoplasms;Mediating;Membrane;Methods;Microcephaly;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic;Modeling;Molecular;Online Mendelian Inheritance In Man;Organelles;overexpression;pericentrin;Phase;Phosphotransferases;Physical condensation;PLK1 gene;polypeptide;Polyribosomes;Process;Proteins;Proteomics;recruit;Role;scaffold;Scaffolding Protein;Seckel syndrome;Side;Testing;Therapeutic;Time;Translations;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Mechanism of centrosome maturation in vertebrates

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: This rigorous and translational study is to exploit a long noncoding RNA APDC (lncR-APDC) as a novel therapy for treating periodontitis, the leading cause of tooth loss. We will determine the biological functions of lncR-APDC in periodontitis via (1) gene knockout strategy; (2) next generation RNA-Seq; (3) state-of-the-art techniques to determine its cellular localization; (4) characterizing the protein and RNA binding partners and chromosomal configuration; (5) mouse periodontitis models to further test the therapeutic effects of lncR-APDC in treating periodontitis. The outcome of this study will provide a paradigm shift in our current understanding of the pathophysiology of periodontitis and advance this rapidly moving research field vertically and significantly.

PI_NAMEs: CHEN, JAKE JINKUN (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adenoviruses;Adult;adult stem cell;Age;alveolar bone;American;Atherosclerosis;Binding Proteins;Biological;Biological Process;Biology;Blood;bone;Bone Marrow Stem Cell;Bone Regeneration;Bone Resorption;Bone Tissue;Cardiovascular system;Cell Differentiation process;Cell Proliferation;cell type;Cells;Cellular biology;Central Nervous System;Clinical;Clinical Trials;Code;Coin;Dental Clinics;Deterioration;Development;Diabetes Mellitus;Disease;Disease Progression;Elements;Endocrine system;Epigenetic Process;Etiology;Family;FDA approved;Fishes;Foundations;Functional disorder;gain of function;Gene Cluster;Gene Expression;gene therapy;Genes;genetic risk factor;human disease;Human Genome;Immune Complex Diseases;Impairment;induced pluripotent stem cell;Inflammation;Inflammatory;insight;knockout gene;Knockout Mice;Laboratories;Length;Link;Literature;loss of function;Macrophage;Malignant Neoplasms;MAP Kinase Gene;Measurement;Measures;Metabolic;microbiome analysis;microCT;Modeling;Molecular;Molecular Biology;mouse model;Mus;neural;new therapeutic target;next generation;novel;novel therapeutics;Nucleotides;Oral Pathology;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;Outcome Study;Outcomes Research;overexpression;palliative;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Periodontal Diseases;Periodontitis;pharmacologic;Play;posttranscriptional;Preventive;Qualifying;Reproductive system;Research;Research Personnel;Research Project Grants;RNA;RNA Binding;Role;Sampling;side effect;Signal Pathway;skills;stem cell differentiation;Stromal Cells;Techniques;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic evaluation;therapeutic target;therapeutically effective;TLR4 gene;Tooth Diseases;Tooth Loss;Transcript;transcription factor;Transcription Process;transcriptome sequencing;translational study;Untranslated RNA;Up-Regulation;virtual

PROJECT_TITLE: A Long Noncoding RNA Amerliorates Periodontitis via Distinct Epigenetic Pathways

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Networking and Information Technology R&D (NITRD);Telehealth

PHR: Project Narrative: There is a clear need for improvement in the diabetes mellitus (DM) transitions of care from the hospital to home. This research focuses on adapting, integrating, implementing, and testing, through a clinical trial, a telehealth diabetes discharge toolkit designed to improve glucose control, safety, and diabetes self-care, and psychosocial measures following discharge from the hospital for those new to DM medications and requiring additional diabetes education. This intervention has the potential to be generalized to DM care in other care settings (e.g., emergency department, outpatient clinic) for DM patients.

PI_NAMEs: WALLIA, AMISHA  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: 2019-nCoV;3D Print;Accident and Emergency department;Admission activity;Adoption;Ambulatory Care Facilities;Award;blood glucose regulation;Caregivers;Caring;Clinical Trials;Computer software;Continuous Glucose Monitor;cost;cost comparison;COVID-19 morbidity;COVID-19 pandemic;Data;design;Devices;diabetes education;Diabetes Mellitus;diabetes mellitus therapy;diabetes self-management;Disease;Distress;Dose;Education;Eligibility Determination;Emergency department visit;Engineering;Enrollment;ethnic diversity;ethnographic method;experience;Failure;Feedback;follow-up;Future;Glucose;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Healthcare;high risk;Home;hospital care;hospital readmission;Hospitalization;Hospitals;Human;Hyperglycemia;Hypoglycemia;implementation evaluation;implementation framework;improved;infection rate;Injections;innovation;Inpatients;Insulin;Intervention;Intervention Trial;Knowledge;Learning;Link;Measures;Medical Care Costs;Methods;Modeling;mortality;multi-component intervention;novel;Outcome;Outpatients;pandemic disease;Patient Discharge;patient population;Patients;Persons;Pharmaceutical Preparations;post-COVID-19;pragmatic trial;Printing;Process;Process Measure;programs;psychosocial;racial diversity;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Project Grants;Safety;Science;Self Care;Self Direction;Self Management;self-directed learning;Severities;simulation;skills;skills training;Skin;socioeconomics;Standardization;System;telehealth;Telemedicine;Telephone;Testing;Time;tool;Training;Training and Education;usability;user centered design;web site;Work

PROJECT_TITLE: Adaption, Implementation and Testing of a Telehealth Diabetes Discharge Intervention to Improve Transitions of Care

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Stroke is a common cause of adult disability, and many stroke survivors suffer from chronically impaired arm function. This proposal seeks to improve future post-stroke rehabilitation therapies by identifying early biomarkers post-stroke that can be used to predict motor control impairments in the chronic stage. This information will then be used to develop and test patient-individualized rehabilitation therapies and may lead to better recovery of motor function after stroke.

PI_NAMEs: BUSZA, ANIA C (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Admission activity;Adult;Affect;arm function;Biofeedback;Biofeedback Training;Biological Markers;Biometry;Blood Vessels;career development;Cell Nucleus;Chronic;chronic stroke;Clinical;Clinical Markers;Clinical Research;Computer Interface;Contralateral;Corticospinal Tracts;Dedications;Development;Development Plans;Diffusion Magnetic Resonance Imaging;disability;Disease;early detection biomarkers;Early identification;efficacy testing;electromyographic biofeedback;Electromyography;Electrophysiology (science);Enrollment;Exercise;Exhibits;experience;Extensor;Fatigue;feasibility testing;Flexor;Fostering;Foundations;Future;Goals;high risk;imaging modality;Impairment;improved;Individual;individual patient;Inpatients;Intervention;Investigation;Investigational Therapies;Ischemic Stroke;K-Series Research Career Programs;Lesion;Location;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Motor;motor control;Motor Cortex;motor deficit;Motor Evoked Potentials;motor function recovery;motor impairment;Motor Neurons;motor recovery;motor rehabilitation;Muscle;Natural History;Neuroanatomy;neuroimaging;neurological rehabilitation;Neurology;novel therapeutics;Output;Patients;personalized medicine;Phase;post stroke;precision medicine;predictive marker;predictive modeling;primary outcome;Program Development;programs;Quality of life;Recovery;Rehabilitation Outcome;rehabilitation strategy;Rehabilitation therapy;Research;research and development;Research Personnel;reticulospinal tract;Risk;secondary analysis;standard care;Stroke;stroke patient;stroke recovery;stroke survivor;Structure;success;System;Techniques;Technology;Testing;Time;Training;Training Support;Transcranial magnetic stimulation;Translating;Upper Extremity;User-Computer Interface;Work;Wrist

PROJECT_TITLE: Early Post-Stroke Biomarkers for Motor Rehabilitation Outcomes

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE:  The manner in which complex molecules are synthesized defines the central role that organic chemistry plays in biology and medicine — a relationship that derives from the impact that chemical synthesis has on the availability of unique small molecules required to discover agents with medicinally relevant profiles. Chemical advances that enable convergent assembly of sterochemically complex polycyclic targets are highly valuable in organic synthesis, as they can provide workable schemes to establish SAR in medicinal chemistry and to produce therapeutically relevant agents. Our scientific pursuits are aimed at addressing the hypothesis that recently discovered fragment-coupling reactions, and unique post-coupling transformations, will have a profound and beneficial impact on the efficiency with which complex molecules are prepared, and will serve as a platform for the discovery of novel natural product-inspired compositions of matter with unique and clinically relevant biological properties. 1

PI_NAMEs: MICALIZIO, GLENN C (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Agonist;Alkaloids;Area;Benzoquinones;Biological;Biology;Cardenolides;chemical synthesis;Chemicals;Chemistry;clinically relevant;Complex;Coupling;cycloaddition;Cytotoxic agent;design;Development;Estrogen Receptor 2;forging;Foundations;Goals;inhibitor;innovation;interest;Investigation;Laboratories;Ligands;lupeol;Mediating;Medicine;Methods;Multiple Myeloma;natural product inspired;Natural Products;non-opioid analgesic;novel;Organic Chemistry;Organic Synthesis;paralogous gene;Pharmaceutical Chemistry;Play;Process;programs;Property;Reaction;Research;Role;Scheme;Science;Skeleton;small molecule;stem;targeted agent;Technology;Terpenes;Textiles;Therapeutic;tool;TP53 gene;Vertebral column;Vision

PROJECT_TITLE: Metallacycle-mediated coupling in stereoselective synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE (OVERALL) The objective of our proposed NYU Collaborative Center in Children's Environmental Health Research and Translation (CEHRT) is to serve as a national resource for the children's environmental health community by: (1) developing meaningful prevention and intervention strategies and messages that have promise to scale, (2) adapting these strategies for diverse populations or settings, to achieve higher population-wide impact, and (3) rigorously quantifying the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. Cross-cutting themes and expertise of our proposed Center include: intervention testing, implementation science, health equity and economic evaluation.

PI_NAMEs: THORPE, LORNA ;TRASANDE, LEONARDO  (contact);TRINH-SHEVRIN, CHAU

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Adoption;Asian Americans;Behavior;Behavior Therapy;Biological Markers;bisphenol A;built environment;Chemicals;Child;Child Health;Clinical Sciences;cohort;Communities;Community Health;design;Development;Diet;dietary;disability;Disease;disorder prevention;dissemination research;economic evaluation;Energy consumption;Environment;Environmental Hazards;Environmental Health;evidence base;Evidence based intervention;Expenditure;exposure reduction interventions;Exposure to;Flame Retardants;Funding;Guidelines;hazard;Health;health communication;health economics;health equity;Home;Hospitals;Household;Human;implementation science;improved;Infrastructure;innovation;Intervention;Investigation;Knowledge;Laboratories;low health literacy;Low income;manufacture;Mentors;Methods;Minority;Modeling;Modification;Multiple Birth Offspring;Muslim religion;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;obesity in children;obesogenic;Organophosphates;Outcome;Pesticides;phthalates;Pilot Projects;Policies;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Population;Population Heterogeneity;Prevention Research;Prevention strategy;Procedures;Public Health;Public Health Practice;repository;Research;Research Personnel;Resources;success;System;Testing;therapy design;Time;tool;Training;Translational Research;Translations;uptake;Work

PROJECT_TITLE: NYU Collaborative Center In Children's Environmental Health Research and Translation


NIH_SPENDING_CATS: Pediatric

PI_NAMEs: TRASANDE, LEONARDO  (contact)

PROJECT_TERMS: Advisory Committees;Award;Behavioral Sciences;Child;Cities;Clinical Sciences;Collaborations;Communication;Communities;Community Health;Competence;Coordination and Collaboration;Development;Discipline;Elements;Environmental Health;Ethnic Origin;Evaluation;Faculty;Funding;Goals;Human Resources;improved;Individual;Infrastructure;Institution;Institutional Review Boards;International;Joints;Lead;Leadership;Letters;Measures;medical schools;Medicine;member;Methods;National Institute of Environmental Health Sciences;New York;Office of Administrative Management;outreach;Peer Review;Pilot Projects;Population Sciences;Prevention Research;Productivity;programs;Public Health Schools;Publications;Race;Research;Research Personnel;Research Support;Resources;Social Sciences;success;Translational Research;translational scientist;Translations;Universities;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The proposed Research Coordinating Center (RCC) will provide objective support and a strong infrastructure, built on a long history of multisite study administration and coordination, to the Nutrition for Precision Health Consortium (NPHC). The RCC will optimize the scientific rigor, data standards and management, implementation of nutrition interventions, and communication in facilitating NPHC, empowered by the All of Us Research Program, to inform strategies that improve nutrition guidance and health across the diverse U.S. population.

PI_NAMEs: GANTZ, MARIE G (contact);MEHTA, SAURABH

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Affect;Algorithms;All of Us Research Program;Artificial Intelligence;Bioinformatics;Biometry;Characteristics;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Communication;Communication Tools;Complex;complex data;Consensus;Custom;Data;Data Collection;data curation;data ecosystem;data exchange;data management;data pipeline;data quality;data standards;data submission;data tools;design;Development;Diet;dietary;Dietary Assessment;Dietary Intervention;Dietary Practices;Domiciles;electronic data capture system;empowerment;Ensure;Epidemiologist;evidence base;experience;FAIR principles;feeding;flexibility;Food Patterns;Funding;Goals;Health;implementation facilitation;improved;Individual;individual response;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intervention;Intervention Studies;Intervention Trial;Leadership;Machine Learning;Medical;meetings;metadata standards;Mission;mobile application;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;Nature;nutrition;Nutrition Assessment;Nutritional;Nutritional Science;Nutritional status;Observational Study;operation;Outcome;Participant;Phase;Phenotype;Physicians;point-of-care diagnostics;Population;Precision Health;precision nutrition;prediction algorithm;Principal Investigator;Privatization;Process;Protocols documentation;Quality Control;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Resources;Safety;sensor;Site;Specimen;Speed;System;Technical Expertise;Technology Assessment;Time;timeline;tool;Training;United States National Institutes of Health;Universities;wearable data;wearable device;wearable platform;web portal;web site

PROJECT_TITLE: Nutrition for Precision Health, powered by the All of Us Research Program:  Research Coordinating Center


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: TRINH-SHEVRIN, CHAU  (contact)

PROJECT_TERMS: Adolescence;air filtration;Air Pollution;Behavioral;career;career development;catalyst;Child;Collaborations;Communication;Communities;Country;Data;design;Development;Dietary Assessment;Dietary Intervention;dissemination research;early childhood;Educational workshop;Environmental Exposure;Environmental Health;experience;Exposure to;Extramural Activities;faculty mentor;flexibility;Fostering;Foundations;Funding;Goals;Health;Health Disparities Research;Health Services Research;implementation science;improved;Individual;indoor air;innovation;innovative technologies;interdisciplinary collaboration;Intervention;Life;Medicine;Mentors;Mentorship;Methods;Monitor;National Institute of Environmental Health Sciences;next generation;peer;personalized approach;Phase;Pilot Projects;Poly-fluoroalkyl substances;population health;Pregnancy;Prevention strategy;Privatization;programs;Public Health Practice;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Scholars Program;Scientist;skills;social epidemiology;Testing;Time;Training;Translating;translational potential;Translational Research;Translations;United States National Institutes of Health;urinary;virtual platform;water treatment;Work

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE  The proposed research is relevant to public health because it could improve treatment and reduce disability for millions of people who suffer from hand and arm paralysis due to stroke, spinal cord injury, and other diseases affecting movement. The project is relevant to the NIH’s mission because it will help us to better understand how paired brain and spinal cord stimulation can be used to strengthen neural connections, and this knowledge could be used to design better treatment protocols.

PI_NAMEs: CARMEL, JASON BRANT (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Affect;arm;arm function;awake;Axon;Behavioral;Brain;Brain Stem;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;Clinical;Clinical Research;Clinical Trials;Cortical Cord;Data;design;dexterity;Diameter;disability;Disease;Dorsal;Electric Stimulation;Electrodes;epidural space;experience;Food;Forelimb;Genetic;Goals;H-Reflex;Hand;Hand functions;Hour;Hyperreflexia;improved;Individual;injury and repair;innovation;invention;Joints;Knowledge;Location;Measures;Mediating;Mission;Motor;Motor Cortex;Motor Neurons;Motor Pathways;Movement;Muscle;Muscle Tension;Nature;neural;neural circuit;Neurostimulation procedures of spinal cord tissue;novel strategies;optogenetics;Pain;Paralysed;Pathway interactions;Pattern;Persons;Physiology;Positioning Attribute;predicting response;Proprioceptor;Public Health;Rattus;Recovery;Recovery of Function;repaired;Research;response;Reticular Formation;sensorimotor system;Sensory;sensory system;Site;skills;Source;Specificity;Spinal;Spinal Cord;Spinal cord injury;Stimulus;Stroke;Supination;System;Techniques;Testing;Therapeutic;Thinness;Time;tool;Translating;Treatment Protocols;United States National Institutes of Health;Viral;Walking

PROJECT_TITLE: Paired Brain and Spinal Cord Stimulation to Strengthen Spinal Sensorimotor Circuits

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative  There is a broad heterogeneity of clinical outcomes after infection with Coccidioides ranging from asymptomatic infection to mild pulmonary disease (“Valley fever”) to a life-threatening, invasive disease called disseminated coccidioidomycosis (DCM). Our team’s long-term goal is to study the intersection of the virulence programs of Coccidioides spp that maliciously exploit defective immunity and the dysregulation of genetic and immunological programs of innate and adaptive immunity that allow for severe disease to take hold.

PI_NAMEs: BUTTE, MANISH J (contact);HOFFMAN, HAROLD M

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;anti-fungal agents;Area;B-Lymphocytes;California;Case Study;Cell Wall;Clinic;Clinical;clinical heterogeneity;Coccidioides;Coccidioidomycosis;Communication;Data;Defect;desert fever;Development;Diagnosis;Diagnostic;Disease;empowerment;Ensure;experimental study;fungus;Genetic;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Host Defense;Human;Immune;Immune Evasion;Immune response;Immunity;Immunodominant Antigens;Immunogenetics;Immunologics;Immunologist;Inbred Strains Mice;Individual;Infection;Innate Immune Response;Investigation;Life;Lung;Lung Diseases;Measures;meetings;Membrane Lipids;model organism;mouse model;Mucous Membrane;multidisciplinary;Mycoses;Natural Immunity;novel strategies;Organism;Outcome;pathogen;Patients;Phagocytosis;Play;Predisposition;premature;prevent;Prevention;prognostic;programs;Publishing;rare variant;Reagent;recruit;Reproduction spores;Research;Research Personnel;Resistance;response;Role;Running;Safety;Sampling;Side;Signal Pathway;T-Lymphocyte;tool;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Host Immunogenetics and Fungal Virulence Mechanisms in Coccidioidomycosis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: THORPE, LORNA  (contact)

PROJECT_TERMS: Adolescence;Adoption;Award;base;Basic Science;career;Center for Translational Science Activities;Child;Child Development;Child Health;Clinic;Collaborations;Communication;Communities;community engagement;community partnership;comparative cost effectiveness;Conceptions;Consolidated Framework for Implementation Research;Cost Analysis;Country;design;Development;Discipline;Disease;Disparity population;econometrics;economic evaluation;Economics;Educational workshop;Effectiveness of Interventions;Environmental Engineering technology;Environmental Exposure;Environmental Health;Environmental Medicine;Epidemiology;ethnic diversity;evidence base;Evidence based intervention;experience;Exposure to;Faculty;faculty mentor;Fostering;Funding;Goals;hazard;Health;health communication;health disparity;health economics;health equity;Health Policy;Hospitals;Housing;implementation science;improved;Infrastructure;innovation;Interruption;Intervention;Life Cycle Stages;Low income;manufacture;Measurement;member;Mentors;Mentorship;Methods;mid-career faculty;Minority Groups;Modeling;multidisciplinary;Muslim religion;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;Natural experiment;Outcome;Pilot Projects;Policies;Population;population health;Population Heterogeneity;prevent;Prevention;Prevention Research;Prevention strategy;primary care clinic;programs;Public Health Practice;Quasi-experiment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;repository;Research;Research Design;Research Personnel;Resources;Schools;Science;Scientist;Series;Services;social disparities;successful intervention;Testing;theories;Time;tool;Toxicology;Training;Translating;translational framework;translational health science;translational pipeline;Translational Research;Translations;uptake;working group;young adult

PROJECT_TITLE: Translation Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: BUTTE, MANISH J (contact)

PROJECT_TERMS: Clinical;clinical phenotype;Clinical Research;Coccidioidomycosis;Communication;conflict resolution;Consultations;data sharing;Databases;Development;Ensure;Expenditure;Fostering;Funding;Genomics;Goals;Group Meetings;Human Resources;Immunogenetics;Immunology;Infrastructure;innovation;Institution;Leadership;meetings;Mentors;National Institute of Allergy and Infectious Disease;organizational structure;Policies;Principal Investigator;Procedures;Productivity;programs;Publications;Records;Reporting;Research;research and development;Resources;Role;Running;Sampling;Scientist;Services;Site;synergism;System;Teleconferences;timeline;United States National Institutes of Health;Virulence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: FIERER, JOSHUA  (contact)

PROJECT_TERMS: Affect;Animal Model;asexual;Biological Assay;Biological Metamorphosis;Biological Products;biosafety level 3 facility;Cells;Chitinase;Chronic;Classification;Clinical Microbiology;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Collection;Complex;CRISPR/Cas technology;culture plates;Dangerousness;Disease Outbreaks;Environment;experience;experimental study;Female;Fungal Genes;fungus;gene conservation;gene function;Gene Mutation;Genes;genetic manipulation;Goals;Immune response;Immunogenetics;In Vitro;Inbred Strains Mice;Inbreeding;Infection;infection risk;Laboratories;Laboratory Personnel;Life Cycle Stages;Lung infections;Mediating;Methods;model organism;Modeling;Molds;mouse model;Mus;mutant;Mutation;Mycelium;new therapeutic target;pathogen;Pathogenesis;Pathway interactions;Plasmids;Predisposition;Recombinants;Reproduction spores;Research Activity;research facility;Research Personnel;Research Project Grants;Resistance;response;Soil;Structure;System;Technology;Testing;Tissues;tool;Virulence;Virulent;women versus men

PROJECT_TITLE: Animal models and fungal mutants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: JOHNSON, ROYCE H (contact)

PROJECT_TERMS: Age;base;Blood;Bronchoalveolar Lavage;California;Case Report Form;Clinical;Clinical Data;Clinical Investigator;clinical phenotype;clinical research site;Coccidioidomycosis;Code;cohort;County;Data;desert fever;Diagnostic;electronic consent;Electronics;Ensure;Ethics;Genetic;Genomics;Goals;Human;human subject;Immunogenetics;Immunologics;Infection;Infrastructure;Institution;Institutional Review Boards;Medical;Patients;Phenotype;phenotypic data;programs;Protocols documentation;Research;Research Design;Research Personnel;Running;Sampling;Services;Shipping;Site;skills;Specimen;Statistical Data Interpretation;synergism;System;Universities;Virulence;Work

PROJECT_TITLE: Clinical Samples Core


NIH_SPENDING_CATS: Diabetes;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Metformin is the most commonly used for the treatment for patients with type2 diabetes that affects hundreds of millions of people worldwide. Our proposal will reveal a novel neural pathway of antidiabetic actions, which is also targeted by metformin, and will potentially create new therapeutic modalities for type 2 diabetes.

PI_NAMEs: FUKUDA, MAKOTO  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: 5'-AMP-activated protein kinase;Accounting;Address;Affect;Anatomy;Anti-diabetic Drugs;Area;Biochemical Pathway;Blood Glucose;blood glucose regulation;Brain;Central Nervous System;Clinical Research;clinical translation;Closure by clamp;Cyclic AMP;Data;Diabetes Mellitus;Electrophysiology (science);energy balance;Equilibrium;euglycemia;experimental study;Extrahepatic;Future;gain of function;GCG gene;Genetic;Glucose;Glucose Clamp;glucose metabolism;glucose output;glucose production;glucose uptake;glycemic control;Glycerol-3-Phosphate Dehydrogenase;Guanosine Triphosphate Phosphohydrolases;Hepatic;Hyperglycemia;Hyperinsulinism;Hypoglycemic Agents;Hypothalamic structure;improved;in vivo;inhibitor;insight;Insulin;Liver;loss of function;Mass Spectrum Analysis;Mediating;Metabolic;Metformin;Methodology;Mitochondria;Modality;Modeling;Molecular;Monitor;Monomeric GTP-Binding Proteins;Mus;neural;Neural Pathways;neuromechanism;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;Organ;Outcome;patch clamp;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phenocopy;postsynaptic;presynaptic;Process;Prosencephalon;Research;Resistance;response;Role;SF1;Signal Transduction;Site;Solid;stable isotope;Sulfonylurea Compounds;Techniques;Testing;Therapeutic;Therapeutic Effect;Thiazolidinediones;Time;Tissues;tool;Tracer;ventromedial hypothalamic nucleus;Work

PROJECT_TITLE: A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


PI_NAMEs: HOFFMAN, HAROLD M (contact)

PROJECT_TERMS: adaptive immune response;adverse outcome;Affect;anti-fungal agents;Antigen Presentation;Aspergillus;base;Binding;Biochemical;Biological;Blood Cells;bone;Brain;Candida;Cell Communication;Cell Physiology;Cells;Cessation of life;chemokine;Clinical;Clinical Immunology;Coccidioides;Coccidioides immitis;Coccidioidomycosis;Collaborations;collaborative approach;Communicable Diseases;cytokine;Data;dectin 1;Dendritic Cells;Disease;disease model;Equilibrium;experience;gain of function;Gene Expression;Genes;Genetic Determinism;Genetic Polymorphism;Genetic study;Genetic Transcription;Goals;Human;Immune;Immune response;Immune System Diseases;Immunity;Immunogenetics;Immunoglobulins;Immunologics;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;innate immune mechanisms;innate immune pathways;Innate Immune Response;interest;Knockout Mice;Learning;Lectin;Leukocytes;Macrophage;Mediating;Molecular;Morbidity - disease rate;mouse model;Mus;Mycoses;Myeloid Cells;Natural Immunity;Natural Killer Cells;neutrophil;new therapeutic target;Outcome;outcome prediction;pathogen;pathogenic fungus;Pathway interactions;Patients;Pattern Recognition;Play;Predisposition;prevent;Process;Production;prognostic indicator;programs;Proteins;receptor;receptor binding;Recording of previous events;recruit;Research Personnel;response;Risk;RNA;Role;screening;sialic acid binding Ig-like lectin;Sialic Acids;Signal Pathway;Signal Transduction;Skin;Source;stem;Structure;Transcriptional Regulation;Translations;Virulence;Virulence Factors;Work

PROJECT_TITLE: Innate immune mechanisms of the host response to Coccidioides


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  Pancreatic ductal adenocarcinoma, frequently subjected to oxygen-limiting environments, is highly refractory to all forms of treatment and novel approaches to inhibit their primary growth and colonization of distant organs are urgently needed. In this proposal, as a potential therapeutic strategy, we will identify and inhibit the metabolic route and enzyme that pancreatic cancers rely on to synthesize aspartate, a metabolite that we previously found to be limiting under hypoxia and whose supplementation increases primary tumor growth and metastatic potential of pancreatic cancer cells. Additionally, the analysis of which metabolic changes pancreatic cancer cells undergo during metastasis will increase understanding of the metabolic rewiring this process triggers and will identify potential metabolic liabilities of metastasis.

PI_NAMEs: GARCIA BERMUDEZ, JAVIER  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Adopted;Amino Acids;Anabolism;Aspartate;Aspartate Transaminase;Award;Biological Assay;cancer cell;Cancer Cell Growth;Cancer Etiology;carboxylation;cell growth;Cell Hypoxia;Cell Line;Cell membrane;Cell Proliferation;Cell Respiration;Cessation of life;Chemicals;Clinic;Collaborations;Conversion disorder;CRISPR screen;Cytoplasm;Dependence;deprivation;Distant;Drops;Electron Transport;Environment;Enzymes;experimental study;Exposure to;Foundations;gene synthesis;Genetic;Glutamine;GOT2 gene;Growth;Hypoxia;improved;In Vitro;in vivo;inhibitor;Injections;Isotope Labeling;Knock-out;Knockout Mice;KRAS2 gene;KRASG12D;Libraries;Liver;Magnetic Resonance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mitochondrial Aspartate Aminotransferase;Modeling;mutant;mutant mouse model;NADH;Natural regeneration;Neoplasm Metastasis;novel strategies;nucleotide metabolism;Nutrient;Organ;Organoids;Oxygen;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic enzyme;pancreatic neoplasm;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Process;programs;Proliferating;Protein Biosynthesis;Refractory;Resistance;Role;Route;Starvation;Stress;Supplementation;Survival Rate;Testing;Therapeutic;tool;TP53 gene;tumor;tumor growth;tumor metabolism;tumor xenograft;United States;uptake;Vascular blood supply;Work

PROJECT_TITLE: Targeting aspartate biosynthesis in pancreatic tumors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI(B)-I]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Pain Research;Palliative Care;Patient Safety;Precision Medicine;Prevention

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE  This project will utilize patient report to examine the short-term and long-term symptomatic adverse events associated with combination therapies that include immune checkpoint inhibitors in early-stage clinical trials. Early assessment of the patient's perspective on personal harms and benefits of these combination immunotherapies will allow for proactive intervention, inform decisions about therapies that might have similar survival outcomes but different symptomatic consequences, and provide timely empirical data for drug developers about the symptomatic effects of their products. This research is relevant to public health and to the National Cancer Institute's mission, in that it will lead to a better understanding of the largely unknown short- term and long-term side effects of combination therapies that include immune checkpoint inhibitors.

PI_NAMEs: GEORGE, GOLDY C (contact);HONG, DAVID S.

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Acceleration;Acute;Address;Advanced Malignant Neoplasm;Adverse event;Affect;Aftercare;Antineoplastic Agents;Arthralgia;Back;cancer immunotherapy;cancer therapy;checkpoint therapy;Chills;Clinical;Clinical Treatment;cohort;Colitis;Combination immunotherapy;Combined Modality Therapy;Community Clinical Oncology Program;Coupled;Data;debilitating symptom;Decision Making;Detection;Deterioration;Development;Diarrhea;Disease;Dizziness;Dose;drug development;Early Diagnosis;Early identification;Early Intervention;early phase clinical trial;early phase trial;Ensure;Event;experience;Fatigue;Fever;gastrointestinal symptom;Headache;Heart;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunotherapy;improved;Institution;Intervention;ipilimumab;Knowledge;Late Effects;Malignant Neoplasms;Measures;Mission;Monitor;Moon;Myalgia;National Cancer Institute;Nausea;New Agents;Nivolumab;optimism;Outcome;Palpitations;Patient Compliance;Patient Outcomes Assessments;Patients;pembrolizumab;Pharmaceutical Preparations;Phase I Clinical Trials;precision medicine;prevent;Public Health;Publishing;Pulmonary Inflammation;Quality of life;Recommendation;Reporting;Research;Research Personnel;Risk;Safety;Shortness of Breath;side effect;standard of care;Supportive care;survival outcome;Swelling;Symptom Burden;symptom cluster;symptom management;Symptoms;targeted treatment;Therapeutic;Therapy trial;Time;Toxic effect;treatment response;United States Food and Drug Administration;University of Texas M D Anderson Cancer Center;Vomiting;Work

PROJECT_TITLE: Use of Patient-Reported Outcomes in Understanding Symptomatic Adverse Events in Early-Phase Trials of Combination Treatments that Include Immune Checkpoint Inhibitors and Targeted Therapy

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


PROJECT_TERMS: adaptive immunity;Alleles;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;ATAC-seq;Automobile Driving;Binding;Catalogs;Cells;Coccidioides;Coccidioidomycosis;COVID-19;Cues;cytokine;Cytometry;Data;Defect;desert fever;Disease;Epigenetic Process;Epitopes;exhaustion;Exhibits;fighting;Functional disorder;fungus;Genes;Genetic;Genetic Transcription;genetic variant;Genome;Genomics;Goals;Haplotypes;Helper-Inducer T-Lymphocyte;high dimensionality;Host Defense;Immune;Immune Evasion;Immune response;Immunogenetics;immunogenic;Individual;Infection;Light;Major Histocompatibility Complex;Measures;Mediating;Modernization;Mus;Mycoses;new technology;pathogen;Pathway interactions;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Play;Predisposition;premature;Process;programs;Publishing;Reagent;receptor;response;Role;senescence;Severity of illness;Signal Transduction;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Study Subject;Subcategory;T cell response;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;tool;transcriptome;transcriptomics;Variant;Virulence;Work

PROJECT_TITLE: Adaptive Immune Dysregulation in Disseminated Coccidioidomycosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetic Testing;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Valley Fever

PI_NAMEs: ARBOLEDA, VALERIE A (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;adaptive immunity;African American;African American population;Asthma;ATAC-seq;Biological Models;Blood;Chromatin;Clinical;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Code;Data;Data Analyses;Data Set;Defect;desert fever;Diagnosis;Disease;DNA;Eczema;Environment;epidemiology study;Epigenetic Process;Ethnic Origin;Ethnic Population;European ancestry;exome sequencing;functional genomics;Genes;Genetic;Genetic Markers;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome-wide;genomic data;genomic tools;Genomics;high risk;Human;Human Genetics;Immune;Immune Response Genes;Immune signaling;Immunogenetics;immunomodulatory therapies;In Vitro;Individual;Infection;Inherited;insight;Latino;Lung infections;Malignant Neoplasms;Molecular;Morbidity - disease rate;mortality;mouse genetics;multiple omics;Mus;Mutation;Natural Immunity;North America;novel;Observational epidemiology;Pathogenesis;Pathogenicity;Pathway interactions;Patient Self-Report;Patients;Persons;Population;Population Group;Primary Infection;Proteins;Publishing;Race;racial population;rare variant;Regulation;Regulatory Pathway;Risk;Risk Factors;risk variant;RNA;RNA Splicing;Role;Sample Size;Severities;sex;Signal Pathway;Signal Transduction;single-cell RNA sequencing;sociodemographics;software development;Source;terabyte;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Validation;Variant;Virulence

PROJECT_TITLE: Human Genetic risk factors for Disseminated Coccidioidomycosis (DCM)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: BEYHAN, SINEM  (contact)

PROJECT_TERMS: Adopted;Arizona;California;Candidate Disease Gene;Cell Culture Techniques;Central America;ChIP-seq;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Custom;cytokine;Data;differential expression;Engineering;Exhibits;exome;experimental study;functional genomics;Fungal Genes;fungus;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Goals;Growth;Immune Evasion;Immune response;Immune system;Immunocompromised Host;Immunogenetics;Infection;infection rate;Knock-out;Light;Lung;metabolome;Mexico;model organism;Molecular;mouse model;Mouse Strains;Mus;mutant;Mycelium;Organism;pathogen;Pathogenicity;Patients;Persons;Phenotype;Pneumonia;Predisposition;Proteins;Proteome;Proteomics;Publishing;Reproduction spores;Resistance;response;Role;Rupture;Soil;South America;Southwestern United States;Structure;Surface;Testing;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Vertebrates;Virulence;Virulence Factors;Volatilization

PROJECT_TITLE: Fungal Virulence: Identifying the factors that control virulence and the growth in parasitic form of Coccidioides


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: The proposed studies will explore the role of gut microbiota in development of cardiovascular disease. The studies will establish a platform for rational therapeutic strategies that will be used for treatment and prevention of cardiovascular disease.

PI_NAMEs: NEMET, INA  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acids;Adrenergic Receptor;Agonist;amino acid metabolism;Animals;Antibiotics;Aromatic Amino Acids;Atherosclerosis;Award;Benzoic Acids;Binding Proteins;Blood Platelets;Bypass;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Catabolism;Cessation of life;Clinical;Clinical Pathways;Clinical Research;Coagulation Process;Cohort Studies;Cresol;Data;defined contribution;Development;Diet Habits;dietary;Dietary Proteins;disease phenotype;Disease susceptibility;Enzymes;Event;Funding;Future;gain of function;Generations;Genes;Genetic Engineering;Germ-Free;Glutamine;Goals;gut microbes;gut microbiota;Health;Healthy Eating;Human;Human Engineering;improved;In Vitro;in vivo;Individual;Lead;Link;Lipoproteins;Liver;loss of function;Maps;Metabolic;Metabolism;metabolomics;microbial;microbial community;microbiome;Mus;mutant;novel;Output;Pathway interactions;Phenotype;phenylacetic acid;Phenylalanine;Phenylalanine Metabolism Pathway;Physiology;Plasma;platelet function;prevent;Production;Receptor Signaling;Reporting;Research;Risk;Role;Sampling Studies;stable isotope;Stroke;Sulfate;Testing;Therapeutic;therapeutic development;Thrombosis;thrombotic;Tracer;Transplantation;Tyrosine;tyrosine analog;Validation;vascular inflammation

PROJECT_TITLE: Gut-microbial metabolism of aromatic amino acids and cardiovascular disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Substance Misuse;Suicide;Suicide Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Body dysmorphic disorder (BDD) is associated with extremely high risk for suicide attempts (22-28%) and substance use disorders (49%), underscoring the importance of accurate, real-time risk detection in BDD. This study aims to use smartphone-based digital phenotyping to develop and validate unobtrusive, time-sensitive, and ecologically valid measures of key risk factors for suicide and substance misuse in BDD: negative affect states. As next steps, this research can be extended to detect risk transdiagnostically, with the goal of enabling just-in-time interventions to target suicide and substance misuse across psychiatric illnesses.

PI_NAMEs: WEINGARDEN, HILARY  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accelerometer;Acute;Address;Adult;Advisory Committees;Affect;Alcohol consumption;Alcohols;American;Anxiety;Area;Assessment tool;Behavior;Behavioral;Body Dysmorphic Disorder;Cannabis;career;career development;Cellular Phone;Clinical;Clinical assessments;Clinical Research;Communication;completed suicide;Data;Detection;Devices;Diagnostic;digital;digital phenotyping;Ecological momentary assessment;emotional distress;Emotions;Ethics;experience;Feeling suicidal;Foundations;General Hospitals;General Population;Goals;Health;high risk;high risk population;Home;Human;In Situ;indexing;Individual;insight;Institution;Intervention;Life;Literature;longitudinal analysis;marijuana use;Massachusetts;Measurement;Measures;medical schools;Mental Depression;Mental disorders;Mentors;Mentorship;Methods;modifiable risk;Monitor;Mood Disorders;National Institute of Mental Health;negative affect;Outcome;Participant;Patient Self-Report;Persons;Phenotype;Process;programs;Psychotic Disorders;Public Health;reducing suicide;Reporting;Reproducibility;Research;Risk;Risk Factors;risk prediction;Ritual compulsion;Sampling;sensor;Series;Severities;Shame;skills;social;social contact;statistical learning;Statistical Models;statistics;substance misuse;substance use;Substance Use Disorder;suicidal risk;Suicide;Suicide attempt;suicide rate;Surveys;Systematic Bias;Technology;Telephone;Testing;Text;Time;tool;Training;Withdrawal;Work;Writing

PROJECT_TITLE: Smartphone-based digital phenotyping to detect high-risk affect states in body dysmorphic disorder

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Narrative:  Cue-induced cocaine seeking precipitates cocaine relapse, which is partially mediated by generation and subsequent maturation of AMPA receptor-silent excitatory synapses within the amygdala-to-accumbens projection. The proposed work will test the hypothesis that upon cue re-exposure after cocaine withdrawal, matured silent synapses become re-silenced and destabilized for ~6 hours within this projection, thus providing a manipulation window to disrupt the cue-cocaine association and decrease cue-induced cocaine relapse. The expected outcomes of this proposal will provide a circuitry-based understanding of cue-induced cocaine relapse and a set of targetable substrates for clinical treatment of cocaine addiction.

PI_NAMEs: DONG, YAN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;AMPA Receptors;Amygdaloid structure;Anatomy;Behavior;Behavioral;Behavioral inhibition;cell type;Clinical Treatment;Cocaine;cocaine cue;Cocaine Dependence;cocaine relapse;cocaine related behaviors;cocaine seeking;cocaine self-administration;Cocaine withdrawal;Cues;Dendritic Spines;Dopamine D1 Receptor;Dopamine D2 Receptor;drug abstinence;drug craving;drug relapse;Drug usage;drug withdrawal;Electrophysiology (science);Excitatory Synapse;Exhibits;experience;experimental study;Exposure to;Generations;Glutamates;Hour;Human;Image;in vivo;in vivo imaging;Knowledge;Mediating;Medical;Memory;Mission;Modification;Molecular;Motivation;N-Methyl-D-Aspartate Receptors;National Institute of Drug Abuse;Neurons;novel;Nucleus Accumbens;optogenetics;Outcome;Pattern;Performance;Pharmaceutical Preparations;postsynaptic;Prefrontal Cortex;prevent;receptor internalization;recruit;Relapse;Research;Rewards;Rodent;Role;Source;Specificity;stem;Structure;Substance Use Disorder;Synapses;synaptogenesis;Testing;tool;Transgenic Mice;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Cocaine-induced adaptation in NMDA receptors

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS