NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Data Science;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Sudden cardiac arrest is a major cause of cardiovascular deaths in the United States with significant disparities among different racial and ethnic groups. These studies will explore the implementation of deep learning methods on electrocardiogram waveform and electronic health record data and develop models using data from populations of diverse ancestry to detect genetic risk for sudden cardiac arrest. This approach could lead to improved risk assessment by capitalizing on the use of readily available clinical data and inform early intervention for patients at risk of sudden cardiac death.

PI_NAMEs: JIANG, JOY  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Algorithms;All of Us Research Program;Amyloidosis;Area;Arrhythmia;Artificial Intelligence;artificial intelligence model;biobank;Biological;Cardiac;Cardiac Electrophysiologic Techniques;Cardiology;cardiovascular risk factor;Cardiovascular system;Catecholaminergic Polymorphic Ventricular Tachycardia;Cessation of life;Classification;Clinical;Clinical Data;clinical decision-making;clinical practice;Clinical Research;clinical risk;Coronary Arteriosclerosis;cost;Data;data integration;data modalities;deep learning;deep learning algorithm;deep learning model;Detection;detection method;Development;Diagnosis;Diagnostic;Disease;Disparity;Disparity population;Doctor of Philosophy;Early Diagnosis;Early identification;Early Intervention;Electrocardiogram;Electronic Health Record;Ensure;Equity;ethnic diversity;Ethnic Population;Faculty;Fellowship;Foundations;Genetic;genetic predictors;Genetic Predisposition to Disease;Genetic Risk;genetic testing;Genomics;Genotype;Goals;Guidelines;Health;Heart Arrest;heart electrical activity;heart function;Heritability;high risk;Hospitals;Human;Hypertrophic Cardiomyopathy;improved;Incidence;Individual;Inherited;insight;Intervention;Left Ventricular Ejection Fraction;Link;Long QT Syndrome;Measures;Mediating;Medical;medical schools;Methods;Minority;Modality;model generalizability;Modeling;Monitor;Morphology;multimodality;Myocardial Infarction;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Outcome;Participant;Pathology;Patients;Pattern;Performance;personalized medicine;Phenotype;Physicians;polygenic risk score;Population Heterogeneity;predictive modeling;Predisposition;Prevalence;prevent;Prevention;programs;prophylactic;Prophylactic treatment;Publishing;racial population;Recording of previous events;repository;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk variant;Scientist;Short QT syndrome;socioeconomic disadvantage;sudden cardiac death;Survival Rate;Syndrome;Techniques;Testing;tool;Training;translational study;Translations;Underrepresented Populations;United Kingdom;United States;wearable device;Work

PROJECT_TITLE: Artificial Intelligence for Determining Genetic Risk of Sudden Cardiac Arrest using the Electrocardiogram

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Prevention;Substance Misuse;Therapeutic Cannabinoid Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  The co-use of cigarettes and cannabis is common and has been shown to negatively affect treatment and other clinical outcomes, yet no treatment recommendations exist to address co-use. The overall goal of this randomized controlled trial is to evaluate varenicline versus placebo, paired with an evidence-based psychosocial intervention, on cigarette abstinence and cannabis use reduction or abstinence (based on participant treatment goals) among adults who co-use. There is an urgent need to evaluate promising co-use treatment interventions and the proposed study is supported by rigorous prior literature, including our own work, and utilizes a decentralized study design and remote intervention delivery to support scalability of this intervention to address co-occurring tobacco and cannabis use.

PI_NAMEs: MCCLURE, ERIN A (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adult;Affect;Age;Area;Behavior Therapy;Biochemical;Cannabis;Cigarette;cigarette smoke;cigarette smoking;Clinical;Combined Modality Therapy;comparison intervention;Counseling;Data;Decentralization;design;Environment;Evaluation;evidence base;FDA approved;Female;Frequencies;General Population;Goals;Harm Reduction;improved;improved outcome;individualized medicine;Intervention;intervention delivery;intervention participants;Legal;Literature;male;marijuana use;Medical Marijuana;Outcome;Participant;Pharmacological Treatment;Pharmacotherapy;placebo group;Placebos;Prevalence;psychosocial;Psychosocial Assessment and Care;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;remote delivery;remote intervention;Research;Research Design;Sex Differences;South Carolina;Time;Tobacco;Tobacco use;Tobacco Use Cessation;treatment comparison;Treatment Efficacy;Treatment outcome;treatment strategy;treatment trial;trial design;United States;varenicline;virtual;virtual delivery;Visit;women versus men;Work

PROJECT_TITLE: Randomized controlled trial of varenicline to treat tobacco and cannabis co-use.

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The ability to resolve ambiguous information is vital in our daily lives. Disrupted interpretive processes and memory biases for ambiguous information are core risk factors and symptoms for major depressive and anxiety disorders. The proposed research will investigate the neural mechanisms that underlie how—when faced with ambiguous social scenarios—individuals initially form, update and ultimately remember subjective interpretations.

PI_NAMEs: SAVA-SEGAL, CLARA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Adopted;Agreement;Anxiety;Anxiety Disorders;Attention;Behavior;behavior prediction;Behavioral;Brain region;Clinical;cognitive control;cognitive process;cognitive reappraisal;Data;Evaluation Reports;Exposure to;Foundations;Friends;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Image Analysis;Impairment;Individual;Learning;Life;Major Depressive Disorder;Measures;member;Memory;Mental Depression;Modeling;Mood Disorders;Natural Language Processing;neural;neural patterning;neuromechanism;Neurosciences;novel;Participant;Pattern;Perception;Play;preference;preservation;Process;Reporting;Research;response;Risk Factors;Role;Sensory;sensory input;sensory stimulus;Series;Shapes;social;Social Environment;Symptoms;Testing;Therapeutic Intervention;Thinking;Time;tool;Update;virtual;Visual Illusions;Work

PROJECT_TITLE: Neural mechanisms of interpretation shifting and memory formation in ambiguous social contexts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: MILWAUKEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Anxiety disorders impact a large fraction of the US population; however, anxiety is significantly undertreated, in part because existing medications can be ineffective or produce intolerable adverse effects. We have identified that inhibition of the binding site of sterol carrier protein 2 (SCP-2) results in reduced anxiety-driven behaviors in mice, likely because this elevates CB1 cannabinoid receptor signaling. The purpose of the studies in this proposal is to design and evaluate new molecules that inhibit SCP-2, with the short term goal of further validating SCP-2 as a target for anxiety and the long-term goal of identifying novel therapeutic agents for the treatment of anxiety.

PI_NAMEs: CUNNINGHAM, CHRISTOPHER W;HILLARD, CECILIA J (contact);LIEDHEGNER, ELIZABETH S

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: 2-arachidonylglycerol;Adult;Adverse effects;Affinity;Agonist;American;Amygdaloid structure;anandamide;antagonist;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety reduction;anxiety treatment;anxiety-like behavior;Attenuated;Behavior;Behavioral;Behavioral Assay;Binding;Binding Proteins;Binding Sites;Biogenic Amines;Biological Assay;Brain;cannabinoid receptor;Cell Membrane Permeability;Cellular Assay;Characteristics;chemical binding;Chemicals;CNR1 gene;Cognition;Computer Assisted;Computer Models;conditioned fear;Data;Dependence;design;Development;Dose;Drug Design;Drug Kinetics;efficacy evaluation;Emotional;endocannabinoid signaling;Endocannabinoids;Enzymes;Exhibits;experience;Extinction;FAAH inhibitor;Face;fatty acid amide hydrolase;Fluorescence;Fright;gamma-Aminobutyric Acid;Generations;Goals;Human;human data;improved;In Vitro;in vivo;inhibitor;innovation;Laboratories;Libraries;Life Cycle Stages;Ligands;Lipid Binding;Measures;Mediating;Metabolic;Metabolism;Molecular Probes;Monoacylglycerol Lipases;Mus;nanomolar;National Institute of Mental Health;non-specific lipid transfer protein;novel;novel therapeutics;Organelles;Pharmaceutical Preparations;pharmacologic;Placebos;Population;Posture;pre-clinical;Pre-Clinical Model;process optimization;Property;Proteins;Quality of life;receptor;Receptor Activation;Receptor Signaling;Regulation;response;reuptake;Role;Scheme;Signal Transduction;Site;small molecule inhibitor;Social Anxiety Disorder;Solubility;Specificity;Stress;System;Technology;Testing;Therapeutic;Therapeutic Agents;Toxic effect;uptake;Woman;Work

PROJECT_TITLE: Development of sterol carrier protein 2 inhibitors as anxiolytics

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Individuals with substance use disorders (SUD) are more likely to use combustible tobacco (cigarettes) and less likely to quit smoking than individuals in the general population, but few efficacious treatment options exist for this population and many SUD programs do not offer tobacco treatment. Electronic nicotine delivery systems (ENDS; e-cigarettes) are non-combusted tobacco products that have been shown to deliver lower levels of toxicants than traditional cigarettes, and represent an appealing, pragmatic and potentially viable alternative to evaluate among an SUD treatment population. The proposed Hybrid Type 1 effectiveness-implementation trial will evaluate the impact of a tobacco harm reduction strategy, namely switching to ENDS, compared to quitting with traditional pharmacotherapy on cigarette smoking, SUD treatment outcomes and engagement and will evaluate implementation outcomes to support the eventual dissemination of this harm reduction strategy within SUD treatment settings.

PI_NAMEs: MCCLURE, ERIN A (contact);SMITH, TRACY TAYLOR

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abstinence;Address;Age;Biochemical;catalyst;Cigarette;cigarette smoking;Client;combustible cigarette;combustible tobacco;Data;Drug Screening;effectiveness-implementation RCT;effectiveness/implementation trial;efficacious treatment;Electronic cigarette;Electronic Nicotine Delivery Systems;Enrollment;evidence base;FDA approved;General Population;Goals;Harm Reduction;Health;Health Promotion;High Prevalence;Hybrids;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;improved;Individual;Intervention;Interview;Leadership;Methods;Morbidity - disease rate;mortality;multi-component intervention;nicotine replacement;Outcome;Outpatients;Participant;patient subsets;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;premature;Prevalence;Proctor framework;programs;Provider;Public Health;Randomized;Randomized, Controlled Trials;Relapse;Research;Resources;Services;Smoke;Smoker;Smoking;smoking cessation;smoking prevalence;South Carolina;substance use;Substance Use Disorder;Testing;Time;Tobacco;tobacco cessation intervention;tobacco products;Tobacco use;Tobacco Use Cessation;toxicant;treatment comparison;Treatment outcome;uptake;Urine;Visit;Work

PROJECT_TITLE: Evaluating a tobacco harm reduction strategy among clients enrolled in substance use disorder treatment


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The ability to discriminate between novel and familiar conspecifics and the decision to approach unfamiliar individuals is critical for the survival of all mammalian specifies. Yet, the neural substrates that encode social recognition and promote social investigation remain poorly understood. This proposal will investigate the role of the ventral hippocampal-lateral septum- nucleus accumbens pathway in mediating novelty-related social investigation.

PI_NAMEs: DYKSTRA, BENJAMIN FORREST (contact)

PROJECT_TERMS: Aggressive behavior;Alzheimer's Disease;Animals;Behavior;Behavioral;Behavioral Assay;Brain region;Calcium;cohort;debilitating symptom;Disease;Goals;Hippocampus;Image;in vivo;Individual;insight;Investigation;Knowledge;Lateral;Measures;Mediating;Mus;Nervous System Disorder;neural;Neurons;novel;Nucleus Accumbens;optogenetics;Pathway interactions;Play;Population Projection;Positioning Attribute;rabies viral tracing;Research;Resolution;Role;Sensory;Series;social;Social Behavior;social influence;Specific qualifier value;Stimulus;Structure;Synapses;Techniques;Testing;transmission process

PROJECT_TITLE: Identifying the Neural Substrates of Novelty-Related Social Investigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Word production deficits are ubiquitous in aphasia, a language disorder affecting more than 2.4 million people in the United States. Semantic Feature Analysis is one of the most commonly used word production treatments for persons with aphasia and involves participants generating semantic features associated with treatment target words; however, little is known of the mechanism of action supporting the treatment. The proposed study will address this knowledge gap by investigating the neurocognitive mechanisms that support semantic feature generation in persons with aphasia and healthy adults and examine the relationship between person- level behavioral measures of semantic and phonological processing and neural data associated with conceptual representations of concrete nouns.

PI_NAMEs: SWIDERSKI, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: The neurocognitive mechanisms underlying semantic feature generation in persons with aphasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative This proposal describes the training and mentoring of Ms. Sarah Adams and her research project to treat solid tumors using a novel biomaterial in conjunction with a split and programmable chimeric antigen receptor (CAR) T cell system. Using this system, she describes a method for overcoming barriers to efficacy of CAR T cells in solid tumors, specifically poor T cell persistence in the tumor microenvironment, lack of specific antigens, and treatment-limiting adverse effects. The capability of this novel therapeutic system to promote CAR T cell proliferation, prevent antigen escape, and mitigate adverse events will be evaluated.

PI_NAMEs: ADAMS, SARAH C (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: A549;Abraxane;Adaptor Signaling Protein;Adverse effects;Adverse event;Animal Model;Antigen Targeting;Antigens;arm;Awareness;Biocompatible Materials;Biodistribution;Biological Availability;bioluminescence imaging;biomaterial compatibility;Biomedical Engineering;cancer cell;Cancer cell line;Cancer Model;cancer therapy;CAR T cell therapy;career networking;cell motility;Cell Proliferation;Cells;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Medicine;Clinical Skills;clinically relevant;Communication;Complex;CRISPR/Cas technology;CXCL9 gene;cytokine;cytokine release syndrome;design;Development;Development Plans;Drug Delivery Systems;Educational workshop;efficacy evaluation;Encapsulated;engineered T cells;Engineering;Event;exhaustion;Exhibits;experimental study;Goals;Hematologic Neoplasms;Hydrogels;IL7 gene;Immune response;Immunocompetent;Immunology;Immunotherapy;implantation;improved;In Situ;In Vitro;in vivo;in vivo Model;Injectable;Injections;innovation;Interdisciplinary Study;Kinetics;Knock-out;Laboratories;Leucine Zippers;Lewis lung carcinoma cell;Logic;Lung;lung cancer cell;Malignant neoplasm of lung;Mentors;Methods;migration;Modeling;Monitor;mouse model;MSLN gene;multidisciplinary;Mus;novel;novel therapeutics;Operative Surgical Procedures;Organ;Population;prevent;Prevention;professor;programs;Proliferating;Proteins;Reporting;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Risk Reduction;ROR1 gene;Safety;Scientist;self assembly;Shapes;Signal Transduction;Site;skills;Solid Neoplasm;spatiotemporal;Specificity;success;Surgeon;Surgically-Created Resection Cavity;symposium;System;T cell anergy;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Thoracic Surgical Procedures;Toxic effect;Training;translational potential;Translations;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Universities;Xenograft procedure

PROJECT_TITLE: Development of a Tunable Protein Release Hydrogel for the Enhancement of CAR T cell Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Colorectal Cancer;Digestive Diseases;Physical Activity;Prevention;Rehabilitation

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Colorectal cancer survivors (CRCS) are at an increased risk of negative physiological and psychological consequences such as cognitive impairment and vascular dysfunction that might be worsened by physical inactivity. The proposed study will yield a novel understanding of these variables in CRCS and also provide new insights into the associations among these variables as well as providing understanding on the putative mechanism of vascular function mediating the relationship between physical activity and cognition.

PI_NAMEs: DEJONGE, SYDNEY RAE (contact)

PROJECT_TERMS: Accelerometer;actigraphy;Adult;Advisory Committees;Aftercare;Age;age related decline;anti-cancer treatment;arterial stiffness;Auditory;Behavior Therapy;behavioral outcome;Blood Vessels;Body mass index;brain health;Breast Cancer survivor;Calibration;cancer diagnosis;Cancer Survivor;Cardiovascular Physiology;cardiovascular risk factor;career;chemotherapy;Chronic Disease;clinical application;clinical training;Cognition;Cognitive;cognitive function;cognitive performance;Collaborations;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;comorbidity;comparative;Comparative Study;computerized data processing;Data;design;Development;Diabetes Mellitus;Diet Habits;Disease;Educational Intervention;Excision;executive function;Exercise;exercise training;Exhibits;experience;Faculty;Female;Femur;Floor;Foundations;General Population;Goals;Growth;Hyperlipidemia;Hypertension;Immunotherapy;Impaired cognition;Impairment;improved;Incidence;insight;International;Learning;Longevity;male;Malignant Neoplasms;Measures;Mediating;Mediator;Memory;moderate-to-vigorous physical activity;modifiable risk;multiple sclerosis patient;Nature;Neuropsychological Tests;novel;Obesity;Oncology;Outcome;Outcome Study;Patients;Pattern;Persons;Physical activity;Physical Exercise;physical inactivity;Physiologic pulse;Physiological;Population;Positioning Attribute;Preventive;Primary Neoplasm;processing speed;psychologic;psychological outcomes;Quality of life;Race;Radiation therapy;Recommendation;Recurrence;reduce symptoms;Research;research study;Research Training;Risk;Risk Factors;Role;sex;Short-Term Memory;side effect;Smoking;Survivors;survivorship;Testing;Therapeutic;Toxic effect;Training;Training and Education;tumor progression;United States;Vascular Diseases;vascular endothelial dysfunction;Verbal Learning

PROJECT_TITLE: Cognition, Vascular Function, and Physical Activity in Colorectal Cancer Survivors


NIH_SPENDING_CATS: Breast Cancer;Cancer;Prostate Cancer;Urologic Diseases;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: This project is relevant to the missions of the NIH and the NCI because prostate cancer is a leading cause of cancer death among US men. The roles of cancer associated fibroblasts in prostate cancer metastasis and androgen receptor signaling inhibitor (ARSI) resistance are largely unknown.  Successful completion of the aims in this research proposal will provide fundamental knowledge about the mechanisms driving metastasis and ARSI therapy resistance which will ultimately lead to reductions in death and suffering from prostate cancer.

PI_NAMEs: HURLEY, PAULA JILL (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;androgen independent prostate cancer;Androgen Receptor;Antibody-drug conjugates;asporin;Automobile Driving;Binding;Bioinformatics;biomarker development;Bypass;Calcium;Calcium Oscillations;Calcium Signaling;Cancer Biology;cancer biomarkers;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;cell motility;Cessation of life;Clinical;Clinical Trials;Communication;Confocal Microscopy;Cytoplasm;Cytoskeleton;Data;Dependence;Development;Disease;Disease Progression;enzalutamide;ERBB2 gene;ERBB3 gene;Fibroblasts;Focal Adhesions;Generations;Genetic Transcription;Goals;human model;In Vitro;in vivo;Incidence;inhibitor;inhibitor therapy;innovation;Innovative Therapy;Knowledge;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;Mediating;Mediator;men;Metastatic breast cancer;Metastatic Prostate Cancer;migration;Mission;Molecular;mouse model;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;Oncology;Outcome;Pathology;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;PIK3CG gene;programs;Prostate;prostate cancer cell;prostate cancer metastasis;Protein Secretion;ratiometric;Receptor Signaling;Recurrence;Reporting;Research Design;Research Proposals;Resistance;Role;Signal Induction;Signal Transduction;small molecule inhibitor;standard of care;structural biology;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy development;therapy outcome;therapy resistant;Tissues;Trastuzumab;treatment strategy;tumor;tumor microenvironment;tumor progression;United States National Institutes of Health

PROJECT_TITLE: Defining Tumor Microenvironmental Mediators of Prostate Cancer Metastasis and Therapy Resistance

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Robotic exoskeletons improve an individual’s ability to navigate their community and have the potential to reduce the risk of falling; however, current exoskeletons do not assist in balance control. This project will develop a generalizable, physiologically-inspired controller for a multi-joint exoskeleton to enhance reactive balance control during standing and walking. This work could lead to significant advances in the usability of robotic exoskeletons for balance control, which can ultimately be used to develop exoskeletons aimed at improving balance in individuals at a high risk for falls, including older adults and individuals with neuromuscular pathologies.

PI_NAMEs: JAKUBOWSKI, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acceleration;Address;Algorithms;Ankle;balance recovery;Biological;Breathing;Communities;Custom;Data;deep learning;design;Devices;efficacy evaluation;Electromyography;Equilibrium;Event;exoskeleton;fall injury;Fall prevention;fall risk;falls;Feedback;Future;Gait;Goals;high risk;high risk population;Hip region structure;Human;improved;Individual;Injury;instrument;Joints;kinematics;Laboratories;Laws;Learning Skill;Lower Extremity;Machine Learning;machine learning algorithm;Measures;Mediating;Mentors;Mobility decline;Modeling;Motion;Muscle;musculoskeletal injury;neuromuscular;novel;older adult;Older Population;Participant;Pathology;Physiological;Posture;Prevalence;Public Health;response;Risk Reduction;robot exoskeleton;sensor;Software Framework;spatiotemporal;stroke survivor;System;Testing;Time;Torque;Training;Translating;treadmill;usability;Walking;wearable data;wearable device;wearable sensor technology;Work;young adult

PROJECT_TITLE: Physiologically-inspired exoskeleton controller to enhance human balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mitochondria, pivotal for cellular health, are implicated in the aging process, and this study explores how a specific gene, alh-6, influences muscle and mitochondrial health in a worm called Caenorhabditis elegans, which share genetic similarities with humans. By investigating the effects of alh-6 in specific tissues, we aim to uncover mechanisms governing health and longevity in response to mitochondria-muscle dynamics. The findings will contribute crucial knowledge about the link between mitochondrial health and muscle function, offering insights into potential interventions for human muscle-related diseases such as muscular dystrophy and Sarcopenia.

PI_NAMEs: RAMOS, MARIA CARMEN (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;age-related disease;Aging;aging process;aging related;aldehyde dehydrogenases;amino acid metabolism;Amino Acids;Animals;Antioxidants;Apoptosis;biological adaptation to stress;Biosensor;Caenorhabditis elegans;Catabolism;Cell Physiology;Cells;Chemicals;Chromosome Mapping;Communication;Complex;CRISPR/Cas technology;Cytoprotection;Defect;design;Development;Disease;Energy Metabolism;Energy-Generating Resources;Environment;Enzymes;Ethyl Methanesulfonate;Exhibits;Functional disorder;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Germ Lines;Glutamates;hallmarks of aging;Health;healthspan;Heterogeneity;Homeostasis;Human;Imaging Techniques;Impairment;innovation;insight;interest;Intervention;Investigation;Knowledge;life span;Light;Link;Longevity;loss of function;loss of function mutation;Mammals;Measures;mechanical signal;Mediating;Metabolic syndrome;Metabolism;Methodology;Mitochondria;mitochondrial dysfunction;Molecular;Morphology;Motility;Muscle;Muscle Cells;Muscle function;Muscle Mitochondria;Muscular Dystrophies;Mutagenesis;mutant;Mutation;Nature;Neurodegenerative Disorders;Neurons;Organelles;Output;Pathway interactions;Personal Satisfaction;Pharyngeal structure;pharynx muscle;Phenotype;Physiological;Play;Premature aging syndrome;preservation;Production;Proline;proteostasis;Pump;Regulation;Reporter;reproductive;Research;response;restoration;RNA interference screen;Role;sarcopenia;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stress;Structure;System;Techniques;Tissues;transcription factor;transmission process;Xenobiotics

PROJECT_TITLE: Cell autonomous and cell non-autonomous roles for mitochondrial proline catabolism in health and longevity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pulmonary endothelial cells (ECs) experience a physiologic level of shear stress from normal blood flow, with many morbid diseases of the pulmonary vasculature causing derangements in shear stress. The biochemical and functional impact of changes in shear stress are not well defined in pulmonary ECs. I will study the impact of varying degrees of shear stress on regulation of the protein aquaporin 1 in ECs and subsequent effects on EC growth and survival.

PI_NAMEs: CROGLIO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accounting;Acute;acute stress;Agonist;angiogenesis;Animal Model;antagonist;Apoptosis;Apoptotic;AQP1 gene;Arteries;Biochemical;Biochemical Pathway;Biological Assay;Blood flow;blood vessel occlusion;Calcium;career;CASP3 gene;Cell Culture Techniques;cell growth;Cell membrane;Cell Physiology;Cell Proliferation;Cell Survival;cell type;Cells;Cessation of life;Data;design;Disease;Distal;Educational process of instructing;Endothelial Cells;endothelial dysfunction;Endothelium;experience;exposed human population;Exposure to;Fluorescence Microscopy;Foundations;Friction;Functional disorder;functional outcomes;Funding;Goals;Health;Homeostasis;Human;Image;Immunofluorescence Microscopy;In Vitro;in vivo;insight;Ion Channel;K-Series Research Career Programs;Laboratories;Lead;Life;Link;Lung;lung microvascular endothelial cells;Malignant Neoplasms;Measurable;Measurement;Measures;mechanical stimulus;Membrane;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mRNA Expression;novel;overexpression;Pathologic;Pathway interactions;Physiological;Predisposition;preservation;prevent;Proliferating;Proliferating Cell Nuclear Antigen;protein expression;Proteins;Pulmonary Embolism;Pulmonary Hypertension;ratiometric;Rattus;receptor;Regulation;Reporting;Resistance;response;Role;Scientist;shear stress;Signal Pathway;Signal Transduction;skill acquisition;skills;Small Interfering RNA;Smooth Muscle Myocytes;Stains;Stimulus;Surface;Techniques;Testing;Therapeutic;therapeutic target;TRPV channel;Vanilloid;Vascular remodeling;Vascular Smooth Muscle;water channel

PROJECT_TITLE: The Impact of Shear Stress on Aquaporin 1 Expression in the Pulmonary Endothelium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Human Genome;Liver Disease;Orphan Drug;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition of the biliary epithelium and a clinically relevant cause of liver transplantation in the United States. This proposal aims to characterize cellular drivers of periductal fibrosis, a characteristic histopathologic finding in PSC, using single-cell analyses of patient tissue and macrophage-fibroblast co-culture studies. This work will dissect the cellular heterogeneity of the periductal niche and characterize the cell subpopulations that mediate periductal fibrosis, which will promote the development of more effective diagnostics and therapeutics for PSC patient care.

PI_NAMEs: HERB, JAKE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Affect;Architecture;bile duct;Bile fluid;Biliary;biliary tract;Biological Assay;CD14 gene;Cell Culture Techniques;Cell Line;Cells;Characteristics;Cholangiocarcinoma;cholangiocyte;Chromatin;chromatin remodeling;Chronic;Cirrhosis;clinically relevant;clinically significant;Coculture Techniques;Collagen;comorbidity;comparison control;Complex;Development;Diagnosis;Diagnostic;Disease;Duct (organ) structure;end stage liver disease;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Exposure to;Extrahepatic Cholestasis;Fellowship;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genomics;Goals;Heterogeneity;Home;hospital care;Immune;Immune response;In Situ;In Vitro;in vitro Model;in vivo;Inflammatory;Inflammatory Bowel Diseases;intrahepatic;Lesion;Liver;Liver Fibrosis;liver injury;liver transplantation;Macrophage;Macrophage Activation;Maps;Measures;Mediating;medical schools;Mesenchymal;Metabolic dysfunction;microbial;Microscopic;Modeling;Molecular;monocyte;multiple omics;Myelogenous;Myeloid Cells;novel;novel diagnostics;novel therapeutics;Nuclear RNA;Organ;Outcome;Pathologic;Patient Care;patient population;Patients;Pattern;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Physiological;Population;Primary Lesion;primary sclerosing cholangitis;Production;profibrotic cytokine;programs;Proteins;Research;Resolution;Risk;RNA;Sampling;sequencing platform;single cell analysis;single-cell RNA sequencing;Small Nuclear RNA;specific biomarkers;Steatohepatitis;Stromal Cells;Therapeutic;Thick;Tissues;Training;transcriptome sequencing;United States;Work

PROJECT_TITLE: Identifying drivers of periductal fibrosis in primary sclerosing cholangitis using single-cell analysis of patient biospecimens

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Trisomy 21 (Down Syndrome – DS) is the most common genetic abnormality disorder in humans, with an estimated incidence of ~1 in 700 live births worldwide, resulting from triplication of all or part of chromosome 21; however, genetic aneuploidy alone does not fully account for many of the physiological and cognitive deficits associated with this disorder. We previously identified a novel, brain enriched chromatin effector protein, BRWD1, which is triplicated in DS and plays a significant role in the mediation of aberrant patterns of transcription, neurological plasticity and cognitive impairments that define Trisomy 21. Using a unique combination of genetic rescue, behavioral, biochemical, proteomic and epigenomic approaches, we are now mechanistically investigating BRWD1's cell-type specific contributions to neural development and DS associated neurological impairments, with the hopes that such findings will aid in our basic understanding of the molecular phenomena that precipitate DS and inform on the possibility of postnatal treatments for this pervasive disorder

PI_NAMEs: MAZE, IAN S. (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Adult;Affect;Aneuploidy;Animals;autosome;Behavioral;behavioral phenotyping;Binding;Binding Proteins;Biochemical;Biophysics;Brain;Brain region;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Chromosome 21;Cleavage Under Targets and Release Using Nuclease;Clinical;Cognition;Cognitive deficits;Complex;Data;Development;Disease;Down's Syndrome;Epigenetic Process;epigenomics;experience;Female;Funding;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Genomics;Growth;Hippocampus;histone modification;Histones;Human;Impaired cognition;Impairment;in utero;In Vitro;Incidence;Individual;insight;knock-down;Learning;Live Birth;male;Medial;Mediating;Mediation;Mediator;Methodology;Molecular;Molecular Abnormality;mouse Ts65Dn;multiple omics;Mus;nerve stem cell;neural;neurodevelopment;Neurologic;Neurologic Deficit;Neurons;novel;Nucleosomes;Oligodendroglia;Pattern;permissiveness;Phenotype;Physiological;Play;Post-Translational Protein Processing;postnatal;postnatal period;Prefrontal Cortex;protein complex;protein protein interaction;Proteins;Proteomics;Reader;recruit;response;restoration;RNA;Role;Severities;skeletal abnormality;Transcription Elongation;Trisomy;Up-Regulation;Viral;Viral Genes

PROJECT_TITLE: Aberrant chromatin regulatory mechanisms in Down syndrome brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  The goal of the project is to understand the mechanism by which caregiver responsiveness facilitates infants’ language learning by (1) quantifying variation in infants’ elicitation of responses from caregivers during interaction using both behavioral and neural measures, (2) examining infants’ processing of controllable events in a novel functional near-infrared spectroscopy (fNIRS) study, and (3) testing whether caregiver responsiveness predicts infants’ language outcomes because of infants’ neural sensitivity to controllable events. We will quantify variability in infants’ sensitivity to instances of their own communicative success during unstructured interaction between infants and caregivers in families spanning the full spectrum of socioeconomic status (SES) to better understand early sources of individual differences in language learning disparities. The results will enable a mechanistic understanding of infants’ active role in structuring their learning environment, with the ultimate goal of promoting effective language acquisition throughout early development.

PI_NAMEs: ELMLINGER, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TITLE: Neural and behavioral mechanisms of controllability in infants' and toddlers' language development


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Alcohol use disorder (AUD) is a severe health crisis that is characterized by detrimental effects to social relationships and personal wellbeing. The insula-BNST pathway has been implicated in driving AUD- associated behavior, including abstinence-induced negative affect-like behavior and compulsive ethanol consumption. Evidence suggests that insular α4β2 nAChRs are a highly sensitive target for chronic ethanol; thus we propose that these receptors expressed in insula-BNST projecting neurons are implicated in ethanol consumption and negative affect and are a potential therapeutic target for AUD.

PI_NAMEs: WILLIAMS, BENJAMIN M (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acetylcholine;Agonist;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol craving;Alcohol dependence;alcohol exposure;alcohol misuse;alcohol use disorder;Automobile Driving;Behavior;binge drinking;Brain;Brain region;Calcium;Cells;Cessation of life;Chronic;chronic alcohol ingestion;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cost;Data;Diagnosis;diagnostic biomarker;diagnostic tool;Disease;drinking;drinking behavior;drug misuse;Drug usage;Electrophysiology (science);Ethanol;foot;Functional Magnetic Resonance Imaging;genetic manipulation;Goals;Health;hippocampal pyramidal neuron;Hyperactivity;Image;Impulsivity;Individual;innovation;Insula of Reil;knock-down;Lifestyle-related condition;Literature;Macaca mulatta;Measures;Modeling;Molecular;Mus;negative affect;Neurons;nicotinic receptor beta2;Nicotinic Receptors;nonhuman primate;novel;novel diagnostics;Output;Pathway interactions;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Persons;Phenotype;Play;Population;Post-Traumatic Stress Disorders;prevent;prolonged abstinence;Quinine;receptor;receptor expression;receptor function;recruit;Regulation;Relapse;Research;Resistance;Rewards;Role;Shock;Signal Pathway;Signal Transduction;social relationships;Stress;Structure of terminal stria nuclei of preoptic region;success;Testing;Therapeutic;therapeutic target;varenicline;Viral;Virus

PROJECT_TITLE: Role of beta2 nicotinic acetylcholine receptors in the insula-BNST pathway in ethanol consumption and abstinence-induced negative affect.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


PHR: Project Narrative Chronic alcohol use has long-lasting detrimental effects on human cognition and behavior that result from changes in brain function. Here we investigate the impact of chronic alcohol on brain function in a rodent model that allows us to correlate neural changes with cognitive function using a decision-making task, focusing on cortical-striatal circuitry. We will test whether brain activity changes will last weeks to months after chronic alcohol in an attempt to find an appropriate model for the persistent neural impairments observed in humans with AUD.

PI_NAMEs: JANAK, PATRICIA H. (contact)

PROJECT_TERMS: alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;Animal Model;Anterior;Area;Behavior;Behavior Control;Behavioral;Brain;Choice Behavior;Chronic;chronic alcohol ingestion;cingulate cortex;Cognition;Cognitive;cognitive control;cognitive function;cognitive process;Communication;Corpus striatum structure;Decision Making;density;design;designer receptors exclusively activated by designer drugs;Electrophysiology (science);Ethanol;executive function;Exposure to;flexibility;frontal lobe;Human;human model;Impairment;Implant;Left;Link;maladaptive behavior;male;Mediating;Mediation;Modeling;neural;neural circuit;neural correlate;neural network;neuromechanism;Neurons;neurotransmission;optogenetics;Outcome;Pattern;Performance;Physiological;Population;Probability;Process;Rattus;Reversal Learning;Rewards;Rodent Model;Role;Self Administration;Structure;Synapses;Task Performances;Testing;Update;vapor;Withdrawal;Work

PROJECT_TITLE: Neural Circuit Effects of Chronic Alcohol

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Movement is essential to our everyday lives, giving us the freedom to interact with a rich, complex world around us. This proposal seeks to understand how motor cortical dynamics generalize from supporting artificially constrained behavior to freely-moving, naturalistic behavior, allowing for more real-world applications to be trans- lated from the basic scientific findings in the motor systems field. This work has applications for understanding how the cortical control of natural, everyday motor functions can be disrupted in people with stroke or traumatic brain injury and can help optimize the decoding of naturalistic movements for assistive neurotechnology, such as neural prosthetics, for those with motor disabilities to restore the freedom of movement.

PI_NAMEs: JUN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TITLE: Neural dynamics of freely-moving, naturalistic behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Heart Disease;Lung;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Overlap syndrome is a common condition with devastating cardiovascular consequences, but research into this condition can be difficult due to heterogeneity in the severity of obstructive lung disease and apneas. The goal of this mechanistic research study is to determine key indicators of cardiac dysfunction by cardiac MRI assessment. The findings of this study may redefine the condition clinically by its adverse cardiac changes rather than by traditional paradigms.

PI_NAMEs: RAPHELSON, JANNA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Adult;Affect;Age;Apnea;Attention;Automobile Driving;Award;Biostatistical Methods;Blood Vessels;Breathing;Cardiac;Cardiac health;cardiac magnetic resonance imaging;Cardiac Output;cardiovascular risk factor;Cardiovascular system;career;Categories;Cause of Death;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinical;cohort;comorbidity;Complex;Continuous Positive Airway Pressure;coronary fibrosis;Critical Care;Data;Development;Disease;Endothelium;Ensure;exercise capacity;Exposure to;Fellowship;Foundations;Functional disorder;Funding;Gases;Goals;Grant;Guidelines;Heart;Heterogeneity;high risk;Hypoxemia;Hypoxia;Image;Impairment;improved;indexing;Individual;insight;Intervention;Laboratories;Left;Left Ventricular Remodeling;Left ventricular structure;Link;Lung;magnetic resonance imaging biomarker;Measures;Mentors;mortality;Myocardial dysfunction;Obstructive Lung Diseases;Obstructive Sleep Apnea;Outcome;Patients;personalized medicine;Persons;Physicians;Physiology;Pilot Projects;Population;Positioning Attribute;Prevalence;primary outcome;Prognosis;randomized trial;Research;Research Infrastructure;Research Personnel;research study;respiratory;right ventricular remodeling;Right ventricular structure;Risk;Running;Scientist;secondary outcome;Severities;Severity of illness;skill acquisition;skills;Sleep;Sleep Apnea Syndromes;sleep physiology;supportive environment;Syndrome;Testing;Thick;Time;Tissues;tool;Training;trial design;United States National Institutes of Health;Ventricular;Vision;Work

PROJECT_TITLE: The Left and Right Ventricles in Sleep Apnea with COPD


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Niemann-Pick disease type C is a childhood-onset neurodegenerative disease with no FDA-approved therapeutics. This application seeks to define the protein homeostasis (proteostasis) regulators of the disease- causing protein, NPC1, in human neurons. This work will contribute to our understanding of the machinery that regulates NPC1 folding and trafficking and will uncover potential targets for therapeutic intervention in Niemann- Pick C disease.

PI_NAMEs: AZARIA, RUTH D. (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Amino Acids;analog;Autophagocytosis;autosome;Binding;Biochemical;Biological Assay;C-terminal;Cells;Cessation of life;Childhood;Cholesterol;cholesterol analog;clinical phenotype;Communication;CRISPR interference;CRISPR/Cas technology;Data;Development;Disease;Endoplasmic Reticulum;FDA approved;Fibroblasts;Genes;Genetic;Goals;Half-Life;Human;human induced pluripotent stem cells;human stem cell-derived;Hydroxycholesterols;Image;Impairment;improved;in vivo evaluation;Induced Neurons;induced pluripotent stem cell;Investigation;Isoleucine;late endosome;Learning;loss of function mutation;Lysosomal Storage Diseases;Lysosomes;Measures;Mediating;Membrane Glycoproteins;Michigan;Missense Mutation;Molecular Chaperones;Neimann-Pick's Disease Type C;nerve stem cell;Neurodegenerative Disorders;Neurologic;neuron development;Neurons;novel;NPC1 gene;Oral;Pathway interactions;Patients;pharmacologic;Phenotype;Positioning Attribute;Postdoctoral Fellow;progressive neurodegeneration;Proteins;proteostasis;Publishing;Research;Research Personnel;Resources;Role;Scientist;Seizures;skills;Stable Isotope Labeling;Sterols;success;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;therapeutically effective;Threonine;trafficking;Training;Universities;Work;Writing

PROJECT_TITLE: Investigating mechanisms of NPC1 proteostasis in human neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Clonal hematopoiesis increases the risk of a diverse array of diseases and studies found most individual over the age 55 have at least one detectable mutant clone. Though we have a growing understanding of drivers of clonal expansion in single mutant studies, the dynamics of interactions between clones requires further exploration. Here, we propose to investigate the unexplored interactions and competition between clones that influence clonal expansion dynamics.

PI_NAMEs: THATAVARTY, APOORVA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acceleration;Affect;Age;age related;age-related disease;Automobile Driving;biological adaptation to stress;Blood Cells;Bone Marrow;Cardiovascular Diseases;cell type;Cells;Chronic;chronic liver disease;Clonal Expansion;Clonal Hematopoietic Stem Cell;Comb animal structure;cytokine;Data;Disease;DNA Modification Methylases;Environment;Epigenetic Process;experimental study;Extinction;Feedback;fitness;Future;Gene Expression Profile;Genes;Genetic Transcription;Health;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Immune;Impairment;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-6;Lipopolysaccharides;Macrophage;mathematical model;Measures;Mediating;Modality;mosaic;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Mycobacterium avium;Polyvinyl Alcohol;Population;pressure;prevent;Prognosis;Protein translocation;Publishing;Resistance;resistance mechanism;response;Risk;Risk Factors;RNA Sequences;Sampling Studies;self-renewal;sex;single-cell RNA sequencing;small molecule;stem cell proliferation;Stimulus;stressor;Therapeutic;therapeutic target;TNF gene;Transplantation;Variant;Work

PROJECT_TITLE: Cellular Interactions and Competition in Clonal Hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: AT

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  Despite accumulating evidence for the benefits of mindfulness, the brain bases are as yet poorly understood. This project aims to (1) identify how functional brain variations correlate with individual differences in mindfulness, and (2) identify how brain connectivity changes during states or moments of mindfulness. To achieve this goal, this research involves big data machine learning methods and analyses of task-based and self-report measures of mindfulness.

PI_NAMEs: TREVES, ISAAC  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Adolescent;Adult;Area;Attention;Awareness;Behavior;Big Data;Brain;brain based;Clinical;cohort;connectome;Data;Data Collection;Data Set;experience;Functional Magnetic Resonance Imaging;Goals;improved;Individual;Individual Differences;insight;interest;large datasets;Life;Link;Machine Learning;machine learning method;Measures;Mediator;Methods;Mind;mindfulness;Modeling;neural correlate;Parkinson Disease;Participant;Patient Self-Report;Personal Satisfaction;predictive modeling;protective effect;Psychopathology;Questionnaires;Research;response;Rest;rumination;Sampling;Scanning;sustained attention;Symptoms;task analysis;Test Result;Testing;Time;time use;Training;trait;Variant

PROJECT_TITLE: The Brain Bases of Mindfulness

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is a rare chronic disease in which allergic inflammation causes disruption of the epithelial barrier. This proposal seeks to elucidate the role of ecto-enzyme CD73 (5'-nucleotidase enzymatic adenosine support evaluation of CD73 and/or purines as a metric of epithelial healing in EoE unveil targeting ecto) and i ts end-product adenosine in promoting epithelial homeostasis and to understand how perturbations in  signaling in the setting of EoE contribute to epithelial disruption. These studies have potential to of purinergic signalingas a novel therapy in EoE.

PI_NAMEs: MUIR, AMANDA BROOKE (contact);WHELAN, KELLY A

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;5'-Nucleotidase;Adenosine;Adenosine Monophosphate;ADORA2B gene;Adrenal Cortex Hormones;Allergic;Allergic Disease;Allergic inflammation;Architecture;Basal Cell;Binding;Biological Products;Cells;Chronic;Chronic Disease;Clinical;Clinical Management;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Cyclic AMP;cytokine;Data;dietary;Disease;Disease remission;Endoscopy;Eosinophilia;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Esophageal Tissue;Esophagus;Evaluation;Exhibits;experimental study;extracellular;Financial Hardship;Genetic;healing;healthcare burden;Heterogeneity;Histologic;Histology;Homeostasis;Human;human subject;improved;Incidence;Inflammation;Inflammatory;Interleukin-13;Interleukin-4;Intervention;keratinocyte;Knock-out;Maintenance;Measures;Mediating;Membrane;Modeling;Molecular;mouse model;Mus;novel therapeutic intervention;novel therapeutics;Organoids;patient population;Patients;pharmacologic;Proliferating;Publications;Publishing;Purine Nucleosides;Purines;Quality of life;Refractory;Regulation;response;Role;Severity of illness;Shapes;Signal Transduction;single-cell RNA sequencing;Squamous Epithelium;stem cell population;Supplementation;Symptoms;Testing;Therapeutic;tissue regeneration;Tissues;treatment response;treatment strategy;Work

PROJECT_TITLE: The role of CD73 in esophageal epithelial homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative: The global shortage of blood for transfusions and the challenge of treating hematological disorders highlight the need for a deeper understanding of Hematopoietic Stem and Progenitor Cell (HSPC) differentiation into erythroid lineages. This project aims to explore the complex gene regulatory networks and transitional states in HSPC differentiation using advanced computational algorithms. Insights gained from this study could lead to more effective strategies in managing blood disorders.

PI_NAMEs: FARHAT, ALI MOHAMAD (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Address;Adult;algebraic topology;Algorithm Design;Algorithms;Atlases;Benchmarking;Biochemical Reaction;Biogenesis;Biological;Biology;Blood Transfusion;Bypass;cell fate specification;Cell Lineage;cell type;Cells;cellular engineering;Chicago;Classification;Complex;Computational algorithm;computerized tools;Data;Data Set;Development;Doctor of Philosophy;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Exhibits;experimental study;Face;Gene Expression;gene network;gene regulatory network;Genes;genetic makeup;Genetic study;Genetic Transcription;Goals;Grouping;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;Heterogeneity;high dimensionality;Illinois;In Vitro;innovation;insight;Knowledge;Mathematics;Measurement;Megakaryocytes;Messenger RNA;Methods;Modeling;Mus;Myeloid Progenitor Cells;Nature;network models;Noise;novel;overexpression;Pathway interactions;Performance;Physicians;Play;Population;Principal Investigator;Process;progenitor;programs;Protocols documentation;Publishing;Research;Resolution;Role;Running;Scanning;Scientist;simulation;single-cell RNA sequencing;skills;Specific qualifier value;stem cell differentiation;Time;tool;Training;transcription factor;Universities;Validation;Writing

PROJECT_TITLE: Developing a Novel Algorithm to Infer Cellular Trajectories from Single-Cell RNA Sequencing Data in Hematopoiesis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Our study investigates the “obesity paradox” in melanoma, the finding that obese individuals have improved survival compared to normal weight individuals, by examining adipokines, specifically adiponectin and its influence on melanoma response to BRAF targeted therapy. We also explore the impact of SGLT2 inhibition on adiponectin release and lipid metabolism, with the goal of enhancing BRAF targeted therapy responses by reducing free fatty acid availability in melanoma tumors. This project has the potential to improve melanoma treatment strategies by integrating targeted and metabolic therapies, benefiting a broader range of cancer patients.

PI_NAMEs: LOUGHRAN, THOMAS P. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;Aftercare;anti-tumor immune response;Antibodies;Biological Assay;Blood Glucose;Body Weight;BRAF gene;Cancer Patient;Career Mobility;Cells;Cessation of life;Clinical Data;clinical practice;Coupled;Coupling;Cutaneous Melanoma;cytokine;Data;Dedications;Development;Diabetes Mellitus;Diagnosis;diet-induced obesity;Effectiveness;Evaluation;Excretory function;exhaustion;Exhibits;fatty acid oxidation;Fatty Acids;Future;Glucose;Glycolysis Inhibition;Goals;Growth;High Fat Diet;Hypoglycemic Agents;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;Implant;improved;Individual;Inflammation;Inflammatory;inhibitor;Interleukin-10;Knockout Mice;Life Expectancy;lipid metabolism;Malignant Neoplasms;Measures;Melanoma;Melanoma Cell;Melanoma Tumor;Metabolic;metabolomics;Metastatic Melanoma;Mitochondria;Modeling;mouse model;Mus;Mutate;National Cancer Institute;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel strategies;Obese Mice;obese patients;obese person;Obesity;Patient Care;Patients;Persons;Pharmaceutical Preparations;Play;pre-clinical;Principal Investigator;Production;programmed cell death protein 1;programs;Progression-Free Survivals;receptor;Research;Research Design;Research Training;Resistance;Resources;response;Role;Scientist;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Sodium;stem;success;Surgeon;symporter;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translating;treatment response;treatment strategy;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor-infiltrating immune cells;uptake;Urine;Weight

PROJECT_TITLE: Adipokine Signaling in Melanoma: Unmasking the Obesity Paradox.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PHR: PROJECT NARRATIVE Linking sound associations with behaviorally relevant outcomes is a critical task of the auditory system, as we build and accrue sound associations throughout our lives. The auditory cortex (AC) has been implicated as a site of learning-related plasticity, but the extent to which this plasticity is offloaded to its subcortical antecedants, the medial geniculate body (MGB) and the inferior colliculus (IC), remains unknown. The proposed research will provide fundamental insights into auditory cortical-subcortical interactions over learning and long-term performance, and can help inform strategies to increase central auditory plasticity to compensate for peripheral forms of hearing loss.

PI_NAMEs: KIM, SU JIN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Cortical and subcortical dynamics in the central auditory system across learning and overtraining

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Lung;Precision Medicine;Pulmonary Hypertension;Rare Diseases

PHR: PROJECT NARRATIVE Measurement of right ventricular (RV)-pulmonary arterial (PA) coupling allows for quantification of RV adaptation, which is the primary determinant of disease outcomes in pulmonary arterial hypertension (PAH). Unfortunately, the specialized nature of RV-PA coupling limits its widespread use in the clinical setting. This proposed work aims to identify clinically available metrics which can act as surrogates for RV-PA coupling in order to improve survival predictions and enhance risk stratification in PAH.

PI_NAMEs: ROSEN, DARIN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Algorithms;American;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Catheters;Chest;Clinical;Clinical Data;Clinical Markers;clinical practice;Clinical Research;clinical risk;cohort;Coupling;Cox Proportional Hazards Models;Data;Data Science;Data Set;Databases;Disease;Disease Outcome;Disease Progression;Echocardiography;EFRAC;Enrollment;Event;Exercise;follow-up;Future;Goals;hemodynamics;hypertension treatment;Image;improved;K-Series Research Career Programs;longitudinal analysis;Lung;Measurement;Measures;Methods;model development;Modeling;Multicenter Studies;National Heart, Lung, and Blood Institute;Nature;Outcome;Patients;performance tests;phenomics;predict clinical outcome;predictive modeling;preservation;pressure;Principal Investigator;prognostic;prognostic value;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;pulmonary vascular disorder;Reporting;Research;Research Design;Research Personnel;Research Priority;Resources;response;Rest;Right ventricular structure;risk stratification;Site;skills;Societies;survival prediction;Testing;Time;Training;Transplantation;United States National Institutes of Health;Validation;Ventricular;Work

PROJECT_TITLE: Identifying Clinical Markers of Right Ventricular Adaptation to Improve Survival Predictions in Pulmonary Arterial Hypertension


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ORTHOPEDICS

PHR: This proposal demonstrates how a singular animal ability can be developed as a novel model to study cartilage healing processes. Lizards readily regenerate hyaline cartilage while humans develop scars, and our goal is to elucidate the mechanisms by which lizards effectively reprogram fibroblasts to generate robust sources of new cartilage. This proposal investigates GP130/STAT3 signaling as a molecular switch regulating the balance of pro-regenerative and pro-fibrotic epigenetic pathways underlying blastema-based cartilage formation, with the goal of recreating these processes in humans.

PI_NAMEs: GAMBLE, DARIAN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adult;adult stem cell;Affect;Age;Aging;aging population;Agonist;Amputation;Animals;appendage;articular cartilage;ATAC-seq;Autologous Transplantation;blastema;Cartilage;Cartilage Diseases;Cartilage injury;cartilage regeneration;cartilage repair;Cells;Chondrocytes;Chondrogenesis;Chromatin;Cicatrix;Collection;Connective Tissue Cells;cytokine;Cytokine Receptors;Data;Degenerative polyarthritis;demethylation;Deposition;Derivation procedure;Dichloromethylene Diphosphonate;Disease;DNA;Drug Modulation;Embryo;Enhancers;Epigenetic Process;Equilibrium;Erinaceidae;Exhibits;Exposure to;Family;Fibroblasts;Fibrocartilages;Fibrosis;Gene Activation;Genes;glycoprotein 130;Goals;Growth;healing;Health Expenditures;Human;Hyaline Cartilage;immune cell infiltrate;Impairment;improved;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;Injury;insight;Interleukin-6;Joints;Liposomes;Lizards;Macrophage;Maps;Mesenchyme;Modeling;Molecular;Molecular Target;multipotent cell;Natural regeneration;next generation;novel;Pain;Pathway interactions;Patients;Persons;Phagocytes;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiologic Ossification;Population;prevent;Process;programs;Proliferating;receptor;recruit;regenerative;regenerative biology;regenerative healing;Regenerative Medicine;rehabilitation strategy;repaired;replacement tissue;Reporting;response to injury;Rest;Role;Signal Transduction;Site;smoothened signaling pathway;Source;STAT3 gene;Structure;Tail;Testing;Therapeutic;Time;Tissues;transcriptomics;translation to humans;Tyrosine;United States;wound;wound healing

PROJECT_TITLE: Investigating macrophage assisted reprogramming of lizard fibroblasts during appendage regeneration


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Sugar consumption is a major contributor to nutrition-related chronic diseases including obesity, type 2 diabetes, and heart disease. A policy that requires added sugar warning labels on restaurant menus has the potential to reduce population-level consumption of sugar and lessen the burden of nutrition-related chronic diseases, especially for population groups with higher sugar consumption. This project will evaluate whether, for whom, and how the nation’s first added sugar warning policy affects restaurant purchases.

PI_NAMEs: GRUMMON, ANNA H;RUMMO, PASQUALE  (contact)

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: Adopted;Adoption;Adult;Affect;American;behavior change;Behavioral Sciences;Belief;Beverages;Black race;Calories;Characteristics;Chronic Disease;Cigarette;Cities;Collaborations;Complement;Consumption;Data;Data Collection;Data Set;Data Sources;design;Diabetes Mellitus;Disease;Disparity;Education;Ethnic Origin;Evaluation;Feeling;Food;Food Packaging;Funding;Health;health disparity;Heart Diseases;Hispanic;Income;Individual;innovation;Intake;Intercept;Label;Lead;Location;Low income;Methods;mobile application;Modeling;New York City;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Participant;Persons;pilot test;Policies;Population;Population Group;Positioning Attribute;prospective;psychologic;Quasi-experiment;Race;Recommendation;recruit;Research;Restaurants;Sampling;Site;smartphone application;sugar;Surveys;Thinking;Time;Total Sugar;warning label

PROJECT_TITLE: A large-scale quasi-experimental evaluation of added sugar warning labels in restaurants

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M5)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Women's Health Research

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionally affects Hispanic and African-American women. We hypothesize that changes in Wnt signaling drive the rewiring of the extracellular matrix (ECM), facilitating micrometastases and macrometastases in the lungs. Understanding how Wnt signaling plasticity facilitates metastatic progression will provide insights into how Wnt-driven ECM alterations confer colonization competence to metastatic TNBC cells and contribute to identifying mechanisms for perturbing these changes.

PI_NAMEs: MENDOZA MENDOZA, ERIKA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 3-Dimensional;Accounting;Adherence;Adhesions;Affect;African American Women;aggressive breast cancer;Aptitude;Automobile Driving;Behavior;beta catenin;Biological Metamorphosis;Blood Vessels;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;breast cancer progression;cancer subtypes;Cell Adhesion;Cell Communication;cell growth;cell motility;Cell Survival;Cell-Matrix Junction;Cells;Chemicals;Clinical;Coculture Techniques;Collagen Fibril;Competence;Comprehension;Confocal Microscopy;Coupled;Cues;Development;Distant;effective therapy;empowerment;Endothelial Cells;Endothelium;Environment;Evolution;Excision;Extracellular Matrix;Extravasation;Fibronectins;fitness;Focal Adhesions;Fostering;Functional disorder;Genetic;Genetically Engineered Mouse;Goals;Heterogeneity;Hispanic Americans;In Vitro;in vivo;inhibitor;innovation;insight;Integrins;Invaded;Ligands;Link;Lung;lung colonization;lung metastatic;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mediating;Metastatic Neoplasm to the Lung;Methodology;Micrometastasis;Modeling;Modification;Molecular;molecular marker;Monitor;mortality;Neoplasm Metastasis;neoplastic cell;novel;Organ;Orphan;Outcome;patient prognosis;Pattern;Play;Primary Neoplasm;Process;Prognosis;Proliferating;Protein Tyrosine Kinase;receptor;receptor expression;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Reporter;Research;response;Role;self-renewal;sensor;Shapes;Signal Pathway;Signal Transduction;Site;spatiotemporal;targeted treatment;Techniques;Therapeutic Intervention;therapy design;therapy resistant;TP53 gene;transcriptomics;triple-negative invasive breast carcinoma;tumor;United States;Variant;WNT Signaling Pathway

PROJECT_TITLE: Wnt-driven adhesion and extracellular matrix dynamics in breast cancer metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

PHR: Project narrative: This proposal seeks to use hydrogel engineering to enhance the generation of cardiac organoids from human pluripotent stem cells. This fellowship will investigate how mechanical cues can guide the generation of cardiac organoids, which can guide us to create more representative tissue models that will expediate our understanding of genetic disorders. Furthermore, having a high throughput platform of reproducible organoids will allow us to improve our drug screening and develop better treatment options for heart failure.

PI_NAMEs: MOLLEY, THOMAS GREGORY (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3-Dimensional;activin A;Address;Affect;Animal Model;Architecture;Attenuated;Biochemical;Biophysics;BMP4;Brachyury protein;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Models;career;cell community;Cell Density;cell type;Cells;Characteristics;Cues;Cytoskeleton;Data;Development;Dimensions;Disease;disease model;Disease Progression;Drug Controls;drug discovery;Drug Screening;Engineering;Environment;Fellowship;FGF2 gene;Flow Cytometry;Future;Generations;Genetic;Genetic Diseases;Geometry;Germ Layers;Goals;Heart;Heart failure;heart function;Heterogeneity;Human;human disease;human pluripotent stem cell;human tissue;Hydrogels;Immunofluorescence Immunologic;improved;In Vitro;in vitro Model;insight;interest;Learning;Link;mechanical signal;Mechanics;Mesenchymal Stem Cells;Mesoderm;Mesoderm Cell;Methods;Modeling;morphogens;Natural regeneration;Organoids;Outcome;Paracrine Communication;Pathology;Pattern;Phenotype;Phosphoproteins;Physiological;Play;Pluripotent Stem Cells;polarized cell;pressure;Printing;Process;progenitor;Prognosis;regenerative therapy;Reproducibility;Research;self assembly;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cells;Stratum Basale;Stress;Structure;System;Techniques;Therapeutic;therapeutic development;Tissue Model;Tissues;Traction;Traction Force Microscopy;Training;Variant;Work

PROJECT_TITLE: Harnessing biophysical cues to spatially organize developing cardiac organoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: Project Narrative Lower socioeconomic status (SES) has been linked to reduced cardiometabolic health, which may explain the why inequalities in SES may confer accelerated brain aging - a highly predictive biomarker of risk for Alzheimer's disease and related dementias. However, the extent to which SES relates to brain age, and whether cardiometabolic health accounts for the relationship between SES and brain age has yet to be conclusively determined. This proposal seeks to elucidate the connections between SES, brain age, and cardiometabolic health among midlife adults while also investigating whether these associations extend to older adults.

PI_NAMEs: DRAKE, JERMON  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;Age;age group;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Area;Automobile Driving;Biological;Biological Markers;Blood Pressure;Brain;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chronology;Clinical;cognitive performance;cohort;Data;Data Aggregation;data harmonization;Data Science;Dementia;dementia risk;design;Dimensions;Disadvantaged;Education;Ensure;Equation;Exclusion;Exhibits;experience;Fellowship;Glucose;Goals;Group Meetings;Health;improved;Income;indexing;Individual;Inequality;Intervention;Laboratories;late life;life span;Link;Lipids;Literature;low socioeconomic status;Machine Learning;machine learning algorithm;machine learning prediction;Manuscripts;Measurement;Measures;Mediating;Mentors;Mentorship;middle age;Modeling;National Research Service Awards;Nature;neurobiological mechanism;Neurocognitive;neuroimaging;Obesity;Occupational;older adult;Outcome;Pathway interactions;Patient Self-Report;Pattern;Perception;pre-clinical;predictive marker;Prevention;Public Health;Research;Research Personnel;Risk;risk stratification;Role;Running;Sampling;Savings;Scientist;social disparities;Social status;socioeconomic disparity;Socioeconomic Status;socioeconomics;tau Proteins;Testing;therapy design;Training;Triglycerides;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: Multidimensional Features of Socioeconomic Status, Brain Age, and the Potential Mediating Role of Cardiometabolic Health Among Mid and Late Life Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Lupus;Prevention;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: This proposal aims to unravel the complexities of early-stage Sjogren’s and lupus, focusing on patients with dry eyes and mouth or on individuals who have clinical symptoms suggestive, but not definitive for lupus. By identifying novel autoantibodies and shared molecular pathways, this research will enhance our understanding of disease onset mechanisms, paving the way for improved diagnostics and early therapeutic strategies in autoimmune diseases like Sjögren's disease and systemic lupus erythematosus.

PI_NAMEs: WOOD, REBECCA ADEN (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Age;Age of Onset;American;Antigens;Arthralgia;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmunity;B-Cell Activation;Binding;Biological Assay;biomarker identification;CDH1 gene;Clinical;Clinical Data;cohort;Complement;CSF1 gene;Development;Diagnosis;Diagnostic;Disease;disease classification;Disease Progression;Dissection;Early Diagnosis;Event;Exhibits;experimental study;eye dryness;Family-Based Registry;Fatigue;Frequencies;Future;Gender;Genetic;genetic association;Hypergammaglobulinemia;Immunofluorescence Immunologic;Immunoglobulin G;Immunoglobulin M;improved;Individual;Inflammation;insight;Interferons;Knowledge;Lupus;Lupus Erythematosus;Measures;Medical;Molecular;molecular marker;Morbidity - disease rate;mortality;novel;Oklahoma;Oligonucleotides;Onset of illness;Oral Ulcer;Organ;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Photosensitivity;predictive modeling;Prevention;Prevention trial;Proteomics;Race;Regulation;Regulatory Pathway;repository;Research;Rheumatism;Risk;risk prediction model;Sampling;screening;Serology;Serum;Sjogren's Syndrome;Specificity;Symptoms;Systemic Lupus Erythematosus;Technology;Testing;Therapeutic;therapeutic target;Time;Tissues;Tongue;Toxic effect;Transcript;transcriptome sequencing;treatment strategy;Work;Xerostomia;young woman

PROJECT_TITLE: Early-Stage Autoimmunity in Sjögren's Disease and Systemic Lupus Erythematosus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: RAMPERSAUD, SHAM  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adverse effects;American;Antigens;Antitumor Response;B-Lymphocytes;Biomedical Engineering;Blood Cells;cancer cell;Cancer Patient;CAR T cell therapy;career;CD18 Antigens;CD19 gene;Cell Maturation;Cell Therapy;Cells;Cessation of life;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;clinical translation;cytotoxic;Data;Development;Diagnosis;Discrimination;Disease;efficacy evaluation;efficacy validation;Emerging Technologies;engineered T cells;Engineering;exhaustion;Exposure to;FDA approved;feasibility testing;fusion gene;Genetic;Genomics;Goals;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Human;IL3RA gene;Immune;immune activation;Immunocompetent;immunoengineering;Immunology;Immunotherapy;In Vitro;in vivo;innovation;Integrins;Knowledge;leukemia treatment;leukocyte activation;Maintenance;Malignant Neoplasms;manufacture;Methods;Modality;Modeling;Modification;Molecular;Molecular Conformation;mouse model;Multiple Myeloma;Mus;Myeloid Cells;Nature;neoplastic cell;NF-kappa B;novel;novel therapeutic intervention;Outcome;patient derived xenograft model;Patients;PIK3R3 gene;Population;pre-clinical;preclinical study;pressure;prevent;Prognosis;Proteomics;Publishing;Refractory;Relapse;Research Personnel;response;Rest;Role;Safety;Scientist;screening;Signal Transduction;single-cell RNA sequencing;standard of care;success;Surface Antigens;survival outcome;Survival Rate;T-Lymphocyte;Technology;Therapeutic;therapeutic development;therapeutic target;therapy development;Toxic effect;Training;Translating;Translational Research;Treatment Protocols;treatment response;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Universities;Work

PROJECT_TITLE: Engineering best in class Acute Myeloid Leukemia (AML) CAR-T therapies by enhancing persistence and defining the immune landscape of AML

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Lack of microbial exposure during early life leads to a spectrum of chronic inflammatory disease in adulthood. This proposal aims to understand how immune tolerance to microbes is established in early life. These findings will provide insights on how to therapeutically address intestinal and systemic inflammatory disorders.

PI_NAMEs: CHEN, AMANDA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adopted;Adoptive Transfer;Adult;Age;age related changes;Anti-Inflammatory Agents;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Asthma;atopy;Biological Assay;Blood;Cell Differentiation process;cell motility;Cell Physiology;Cell Separation;Cells;chemokine receptor;chronic inflammatory disease;Clinical Research;commensal microbes;Cues;Cytometry;Data;Dendritic Cells;Dermatitis;Development;Disease;early life exposure;Education;Escherichia coli;Exposure to;Extravasation;fighting;Frequencies;functional outcomes;Goals;gut inflammation;gut microbes;Homeostasis;Immune;Immune response;Immune system;immune system function;Immune Tolerance;Immunity;Immunologics;infancy;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Intestinal Diseases;Intestines;Knowledge;Lamina Propria;Lead;Life;life span;Link;lymph nodes;lymphoid organ;Lymphoid Tissue;Macrophage;Maintenance;Mediating;member;mesenteric lymph node;Microbe;microbial;microbial colonization;microbiome;microbiota;microorganism antigen;migration;monocyte;Mononuclear;Mus;Organ;Outcome;Pathogenicity;Pathology;Phagocytes;Phenotype;prevent;Proliferating;Publishing;recruit;Regulation;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;System;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapy development;Thromboplastin;Thymus Gland;Tissues;trafficking;transcriptome sequencing;Work

PROJECT_TITLE: Investigating the Role of the Microbiome in Mononuclear Phagocyte Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Health Services;Lung;Rare Diseases

PHR: PROJECT NARRATIVE Many survivors of acute respiratory failure (ARF) are left with disabling long-term sequelae of their critical illness, leading to reduced quality of life (QoL). Interventions in the post-intensive care unit (ICU) setting have struggled to improve QoL and there is an urgent need to understand relevant modifiable factors. The goal of this proposal is to elucidate key factors associated with the development of two modifiable contributors to QoL, bothersome uncertainty and health expectations, as these factors are potential targets for novel interventions.

PI_NAMEs: BOUHASSIRA, DIANA  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute respiratory failure;Address;Adult;Adverse effects;Cancer Patient;Caring;Characteristics;Clinical;Clinical Research;Cognitive;cohort;Cohort Studies;Collection;coping;COVID-19 pandemic;Critical Illness;Data;Death Rate;Decision Making;design;Development;Disabling;Ensure;expectation;experience;Funding;Future;Goals;Grant;Health;health assessment;health care quality;Health Personnel;Healthcare;Hospital Mortality;Hospitals;Illness impact;improved;Individual;Influentials;Injury;Inpatients;Intensive Care Units;Intervention;Interview;Knowledge;Learning;Left;long-term sequelae;Malignant Neoplasms;Measures;Mediator;Mentors;National Heart, Lung, and Blood Institute;novel;observational cohort study;Palliative Care;Parents;Participant;Patient Care;Patient Outcomes Assessments;Patients;Perception;physical impairment;Population;Population Sizes;Predisposing Factor;Prevalence;Process;provider communication;psychologic;Qualitative Methods;Qualitative Research;Quality of life;Recovery;Reporting;Research;Research Infrastructure;Research Personnel;Resource Allocation;Shapes;skills;Source;Statistical Data Interpretation;Structure;success;Survivors;Testing;Time;Training;Uncertainty;United States;Work

PROJECT_TITLE: Uncertainty and Expectation Formation in Acute Respiratory Failure Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Summary/Abstract This is a multi-PI project to fill an important knowledge gap: what are the upstream pathways that drive the chronic production of type I interferons (IFN-Is) in immune cells and in skin in systemic lupus erythematosus (SLE)? Elucidating these pathways would enable the development of more effective and potentially much safer new treatments for this disease.

PI_NAMEs: KAHLENBERG, JOANNE MICHELLE;LACAVA, JOHN ;MUSTELIN, TOMAS M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Age of Onset;Binding;Blood;cell type;Cells;Chronic;Clinical;Clinical Trials;computerized tools;Data;Detection;detection method;Development;Disease;DNA;Double-Stranded RNA;Epidermis;Exanthema;experimental study;Fibroblasts;Flare;Genes;Goals;Heteroduplex DNA;Human Cell Line;Human Engineering;Hybrids;IFNAR1 gene;Immune;Inflammatory Response;Interferon Type I;Joints;keratinocyte;Knowledge;Laboratories;Ligation;Location;Lupus;Michigan;mimicry;Mitochondrial DNA;Modeling;Molecular;monocyte;neutrophil;new therapeutic target;novel therapeutics;Nuclear;nucleic acid binding protein;nucleic acid detection;Nucleic acid sequencing;Nucleic Acids;Paper;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Play;prevent;Prevention;Process;Production;Proteins;Protocols documentation;Research;Resources;response;Retrotransposon;Reverse Transcription;RNA;RNA Sequences;Role;role model;Sampling;sensor;Signal Transduction;Skin;skin biopsy;Source;Symptoms;Systemic disease;Systemic Lupus Erythematosus;Technology;Testing;therapeutic development;Treatment Efficacy;type I interferon receptor;Ultraviolet B Radiation;Ultraviolet Rays;Universities;UV Radiation Exposure;Viral;Washington;Work;Z-Form DNA

PROJECT_TITLE: Upstream drivers of type I interferons in lupus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-S (02)]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Digestive Diseases;Eating Disorders;Mental Health;Mental Illness;Nutrition;Serious Mental Illness

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Heightened gastrointestinal (GI) visceral sensitivity likely maintains restrictive eating disorders, yet this has never been tested. The proposed research tests whether heighted GI visceral sensitivity maintains restrictive eating disorders (i.e., anorexia nervosa [AN], atypical AN, and avoidant restrictive food intake disorder [ARFID]) and examines possible mechanisms underlying altered GI experience in individuals with restrictive eating disorders (i.e., altered GI physiological functioning, GI interoception). Findings have implications for treatment of restrictive eating disorders, such as shifting treatment targets to directly address heightened visceral sensitivity to increase treatment retention and efficacy.

PI_NAMEs: POOVEY, KENDALL NICOLE (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Address;Adult;Anorexia Nervosa;Arrhythmia;aversive conditioning;avoidant restrictive food intake disorder;Behavior;Behavior Disorders;behavior measurement;Biology;Cardiac;Cardiovascular system;career;Collaborations;Communities;Cues;Data;Data Collection;Development;diagnostic value;Disease;Disease remission;Dropout;Eating Behavior;Eating Disorders;Ecological momentary assessment;Electrocardiogram;Esthesia;Exhibits;experience;Exposure to;Fellowship;Fertility;Fright;Functional disorder;Future;gastrointestinal;gastrointestinal function;gastrointestinal system;Goals;Health Care Costs;Height;Hypersensitivity;improved;Individual;innovation;Institution;interest;Interoception;Intervention;Investigation;Laboratories;Learning;Maintenance;Measurement;Medical;Mental disorders;Methods;Monitor;Motility;multilevel analysis;National Institute of Mental Health;Nutritional;Output;Participant;Patient Self-Report;Perception;Persons;Phase;Physiological;Positioning Attribute;Postdoctoral Fellow;Preparation;Prevention;Prognosis;prospective;Psychopathology;Psychophysiology;purge;recruit;Reporting;Research;restrictive eating;Role;Sampling;Satiation;screening;skills;Specificity;Stomach;Strategic Planning;Symptoms;Testing;theories;Time;Training;treatment duration;treatment optimization;treatment strategy;Universities;Visceral;Visit;Washington;Water;Work

PROJECT_TITLE: Investigation of Gastrointestinal Interoception in the Maintenance of Disordered Eating Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The global prevalence of type 2 diabetes mellitus (T2DM) has now reached epidemic proportions, making it a pressing global health concern. Guided by this health crisis, this research proposal aims to build upon our lab’s recent finding that 14-3-3-ζ is a novel regulator of islet cell crosstalk, specifically α-cells and β-cells. The goal of this proposal is to define the regulation of β-cell 14-3-3-ζ expression and how β-cell 14-3-3-ζ regulates islet cell crosstalk to modulate islet function.

PI_NAMEs: SHISHANI, RAHAF  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Adenylate Cyclase;Advisory Committees;Agonist;Alpha Cell;antagonist;Automobile Driving;Beta Cell;Binding;blood glucose regulation;Cell Physiology;Cells;Chemosensitization;Committee Members;Communication;Cyclic AMP;Data;Development;Disease;Down-Regulation;efficacy evaluation;Endocrine;Epidemic;Experimental Designs;Fat-Restricted Diet;G-Protein-Coupled Receptors;Gases;global health;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;Goals;graduate student;Health;High Fat Diet;Human;improved;In Vitro;insight;Insulin;insulin secretion;islet;Islet Cell;Knock-out;Knockout Mice;L Cells;Laboratory Finding;Literature;Mediator;Mentorship;Messenger RNA;Metabolic Diseases;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;pancreatic islet function;Pathway interactions;Periodicity;Play;preservation;Prevalence;Production;proglucagon;Protein Kinase;Protein Secretion;Proteins;Proteomics;Reagent;Receptor Signaling;Regulation;Reporting;Research Personnel;Research Proposals;response;Role;Saline;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Testing;Training

PROJECT_TITLE: A novel role for 14-3-3-ζ in regulating islet cell crosstalk

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


NIH_SPENDING_CATS: Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Kilohertz sacral root block for bladder emptying after spinal cord injury The goal of this project is to determine the effect of sacral root stimulation (SARS) frequency on contractile function of lower urinary tract and bowel organs in order to evaluate the potential for SARS to improve bladder and bowel emptying efficiency for individuals with spinal cord injury. In acute terminal pig experiments, we will measure continuous bladder, urethral sphincter, rectal, and anal sphincter pressures in response to SARS at varying frequencies from 20-10,000 Hz. We will also measure bladder voiding volumes in a subset of stimulation conditions.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Acute;Address;Affect;Anesthesia procedures;Anterior;Ataxia;Autonomic Dysreflexia;Bladder;Brain Stem;Catheterization;Catheters;Chronic;Clinical;Dangerousness;Efferent Neurons;Electric Stimulation;Esthesia;Exhibits;experimental study;Family suidae;Frequencies;Future;Goals;Hydronephrosis;Impairment;improved;Individual;innovation;Intestines;Kidney;Lower urinary tract;Measures;Motor;Muscle;Nerve;neural;Neural Pathways;Neurogenic Bladder;neuromechanism;Operative Surgical Procedures;Organ;Outcome Measure;Pathway interactions;Pelvic Floor Muscle;Pelvis;Penile Erection;Pharmacologic Substance;pressure;primary outcome;Quality of life;Rectum;Reflex action;Reflux;renal damage;response;Rhizotomy procedure;Risk;Sensory;Sex Functioning;Signal Transduction;Sphincter;sphincter ani muscle structure;Spinal cord injury;Spinal nerve structure;Stimulus;Techniques;Testing;Therapeutic;translational potential;Urethra;Urethral sphincter;Urinary Incontinence;Urinary tract infection;Urine


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROEJCT NARRATIVE Heart failure (HF) is a high-risk and costly condition, disproportionately affecting Black individuals in America. Through this grant and its principal aims, we aim to develop and implement deep learning models to enhance the assessment of care quality in heart failure management by: (1) automating the assessment of heart failure phenotypes to evaluate and improve the prescription of evidence-based therapies across diverse populations (2) identifying and addressing social determinants of health and biased language in medical documentation that contribute to disparities in cardiovascular care. The anticipated findings from this work will have a substantial impact on how heart failure care for racially and ethnically diverse populations is measured and conceptualized, thus informing the future of clinical care for one of the most common, high-risk, and high-cost conditions affecting the American population.

PI_NAMEs: ADEJUMO, PHILIP O (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;American;Applications Grants;Attention;automated assessment;Black Populations;Black race;Cardiovascular Diseases;Cardiovascular system;care delivery;Caring;Categories;Clinical;clinical care;clinical encounter;Collaborations;Complex;Consumption;cost;Data;Data Science;Death Rate;Dedications;deep learning;deep learning model;Descriptor;Development;Disparate;Disparity;disparity reduction;Documentation;Echocardiography;Electronic Health Record;Enhancement Technology;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Evaluation;evidence base;experience;feature extraction;Foundations;functional status;Future;Goals;Grant;Guidelines;health equity;Health system;Heart failure;high risk;Hispanic;Hospitalization;Hospitals;improve minority health;improved;improved outcome;Incidence;Individual;innovation;insight;Intervention;Label;Language;Left Ventricular Ejection Fraction;Life Expectancy;Literature;Managed Care;Manuals;Measures;Medical;Medical History;Medicine;Mentors;Methods;Minority;Minority Groups;minority health;minority patient;Modeling;mortality;Natural Language Processing;Outcome;patient population;Patient-Focused Outcomes;Patients;Pattern;personalized care;Phenotype;Physicians;point of care;Population;Population Heterogeneity;pre-trained model;Prevalence;Process;Process Measure;Quality of Care;racial disparity;racial diversity;racial minority;racial minority population;racial population;Recommendation;Reporting;Scheme;Scientist;Shapes;social;social health determinants;Socioeconomic Factors;standardized care;Sterile coverings;Stigmatization;Subgroup;Time;tool;Training;transfer learning;Translations;treatment comparison;treatment disparity;treatment guidelines;treatment optimization;Treatment Protocols;United States;Work;World Health Organization

PROJECT_TITLE: Deep Learning-enhanced Evaluation of Quality of Care and Disparities Among Patients with Heart Failure in the Electronic Health Record