NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Age is considered the leading risk factor for late-onset Alzheimer’s disease (AD) with AD risk doubling every five years after age 65. There is a significant lack in studies that characterize in a systematic and integrative way the contribution of aging to AD development in preclinical stage. We will integrate novel quantitative markers of brain microstructure and network neuroscience and study a well-characterized sample of (older) adults in preclinical AD stage to characterize the neural markers that are vulnerable in aging and contribute to AD.

PI_NAMEs: HOSSEINI, HADI  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age effect;age related;age related changes;Aging;aging brain;aging mechanism;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;amnestic mild cognitive impairment;Amyloid beta-Protein;amyloid pathology;Animal Experimentation;biomarker development;Brain;Brain imaging;Brain region;Clinical;Cognitive;cohort;Communities;compare effectiveness;Compensation;connectome;Consensus;Data;Data Set;density;Development;Diagnosis;Diffusion;Disease Outcome;disease phenotype;gerotherapeutic;Goals;gray matter;Growth;Human;human old age (65+);Impaired cognition;improved;in vivo;indexing;Inflammation;Knowledge;Late Onset Alzheimer Disease;Lipids;longitudinal design;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Medial;Memory Loss;Methods;mild cognitive impairment;mitochondrial dysfunction;Modeling;Morphology;Myelin;neural;neural circuit;neural network;Neurites;neuroimaging;Neurosciences;new therapeutic target;Non-linear Models;normal aging;novel;novel therapeutics;older adult;Organizational Change;Parietal;Patients;Phenotype;Positron-Emission Tomography;pre-clinical;Process;Property;Reporting;Research Priority;Resources;response;Rest;Risk;Risk Factors;Sampling;Signal Transduction;Structure;Synapses;tau Proteins;Techniques;Testing;Tissues;Vascular Diseases;white matter

PROJECT_TITLE: Interactive Effects of Aging and AD on Brain Networks


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Replacement of healthy muscle tissue with intramuscular fat, a shared feature of sarcopenia and neuromuscular diseases such as Duchenne Muscular Dystrophy, results in loss of muscle mass and strength. The short-term goal of this project is to identify mechanisms by which fat replaces muscle, with the long-term goal of developing strategies to counter intramuscular fat infiltration and prevent the decline in muscle function.

PI_NAMEs: KOPINKE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acute;Address;Adipocytes;Adult;Affect;age related;Ants;Biological Assay;Biology;cell type;Cells;Chronic;Cicatrix;Cilia;Coculture Techniques;combat;Data;Development;Diabetes Mellitus;Direct Lytic Factors;Disease;Duchenne muscular dystrophy;Endothelial Cells;Equilibrium;Erinaceidae;experimental study;Fatty acid glycerol esters;Fibrosis;Genetic;Glycerol;Goals;Health;Histology;human disease;improved;In Vitro;in vivo;Infiltration;Injury;innovation;insight;intercellular communication;interstitial;Intramuscular;knockout animal;Knowledge;Ligands;lipid biosynthesis;mdx mouse;Measurement;Modeling;Molecular;mouse model;Muscle;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;muscle strength;Muscular Atrophy;myogenesis;Myopathy;Natural regeneration;Neuromuscular Diseases;novel;novel therapeutic intervention;Obesity;Outcome;Pathogenicity;Pathway interactions;pharmacologic;Positioning Attribute;preservation;prevent;progenitor;Publishing;Regenerative capacity;Reporting;Role;sarcopenia;Schwann Cells;SHH gene;Signal Pathway;Signal Transduction;skeletal muscle wasting;smoothened signaling pathway;System;Testing;therapeutic development;Time;tissue repair;Tissues;tool;Work

PROJECT_TITLE: Ciliary Hedgehog signaling during adult tissue repair and disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Stroke;Unintentional Childhood Injury

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Preterm infants are at high risk for brain injuries due to alterations in brain blood flow and oxygenation, especially after the occurrence of intraventricular hemorrhage, and currently there is no reliable bedside method to monitor these functional parameters continuously in premature brains. This project will develop and test a new, noncontact, fast, high-resolution, and portable optical device, which enables immediate and continuous imaging of brain blood flow, oxygenation, metabolism, and functional connectivity in neonatal piglets and preterm infants. Compared to currently available technologies, this noninvasive, multi-parameter, functional imager will provide a more comprehensive and accurate assessment of neonatal brain health/injury, which may help optimize care for critically ill neonates and reduce harm to their brains.

PI_NAMEs: YU, GUOQIANG  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acute;Aftercare;Algorithms;Autopsy;Biological Markers;Birth;Blood;Blood Vessels;Brain;brain health;Brain imaging;Brain Injuries;brain tissue;Calibration;Case Study;Cephalic;cerebral hemodynamics;Cerebral Ventricles;Cerebrospinal Fluid;Cerebrospinal fluid shunts procedure;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chronic Phase;Clinical;clinical application;Clinical assessments;Complication;Coupled;Coupling;cranium;Critical Care;Critical Illness;density;design;Detection;detector;Development;Devices;Diffuse;Dimensions;Effectiveness of Interventions;Evaluation;Fiber;functional disability;Functional Imaging;Goals;Guidelines;Harm Reduction;Head;high risk;Histologic;Homeostasis;Human;human imaging;Hydrocephalus;Image;imager;Imaging Device;imaging modality;Imaging Techniques;Impairment;improved;in vivo;Inflammation;Injury;innovation;Intervention;Intracranial Hypertension;Intracranial Pressure;intraventricular hemorrhage;Ischemic Brain Injury;Laboratories;Legal patent;Magnetic Resonance Imaging;Measurement;Measures;Medical;Metabolic;metabolic rate;Metabolism;Methodology;Methods;Modeling;Monitor;Multi-modal optical imaging;multimodality;Mus;Near-Infrared Spectroscopy;Neonatal;neonatal brain;Neonatal Brain Injury;Neonatal Intensive Care Units;neonate;Neonatology;neuroimaging;Neurologic Deficit;Neurological outcome;Neurosciences Research;novel;Observational Study;optical imaging;Optics;Outcome;Outcome Measure;Outcome Study;Oxygen;Oxygen Consumption;portability;pre-clinical;premature;Premature Birth;Premature Infant;preservation;preterm newborn;prevent;Property;Rattus;Recovery;Research;Resolution;Safety;Scalp structure;Signal Transduction;Source;standard care;standard of care;Survival Rate;System;Technology;Testing;Three-Dimensional Imaging;tissue injury;tissue phantom;Tissues;tomography;tool;Ultrasonography;Very Low Birth Weight Infant

PROJECT_TITLE: Noninvasive Noncontact High-Density Optical Imaging of Neonatal Intraventricular Hemorrhage

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project narrative (relevance): The five-year survival of patients with acute myeloid leukemia (AML) is only 27.4%, thus there is an unmet need for more effective therapies. In order to improve the outcome of AML patients, it is important to understand the biology of leukemia stem cells (LSCs) which are capable of initiating leukemia and are resistant to treatment. This proposal seeks to understand the mechanisms through which non-leukemia cells (collectively called the microenvironment) in the bone marrow of AML patients support LSCs and to design new therapies that target these mechanisms and eliminate LSCs.

PI_NAMEs: MARCUCCI, GUIDO  (contact);ZHANG, BIN

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Anatomy;Apical;Apoptosis;arteriole;Azacitidine;BCL2 gene;Binding;Biology;Blast Cell;Blood Vessels;Bone Marrow;Bone remodeling;calmodulin-dependent protein kinase II;Cell Cycle;cell growth;Cells;chemotherapy;Cities;Clinic;Clinical;Clinical Trials;Cytogenetics;cytokine;deprivation;design;Discontinuous Capillary;Disease;Down-Regulation;Drug resistance;effective therapy;Endothelial Cells;Endothelium;exhaustion;FLT3 gene;Growth;Hematopoietic stem cells;Homeostasis;Human;improved outcome;in vivo;inhibitor;innovation;insight;Left;leukemia;leukemia treatment;leukemic stem cell;manufacture;Marrow;Messenger RNA;MicroRNAs;Modeling;Molecular;Mus;new therapeutic target;novel;patient derived xenograft model;Patients;Permeability;permissiveness;Play;pre-clinical;prevent;Proliferating;Proteins;Resistance;Role;self renewing cell;self-renewal;stem cell expansion;Testing;therapeutic target;TNF gene;Toxicology;trafficking;Tyrosine Kinase Inhibitor;Untranslated RNA;Vascular remodeling;Vascularization

PROJECT_TITLE: Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Primary Health Care;Social Determinants of Health

ORG_CITY: SALVADOR

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FEDERAL UNIVERSITY OF BAHIA

PHR: Proposal Title: The impact of social determinants, conditional cash transfers and primary health care on HIV/AIDS: an integrated retrospective and forecasting approach based on a cohort of 100 million Brazilians Project Narrative Despite considerable progress has been made in controlling HIV/AIDS epidemics in several countries, challenges remain in terms of scaling up successful national programs. This study will use one of the largest longitudinal dataset from the linkage of socioeconomic and health data to evaluate the effects of socioeconomic determinants, cash transfer programmes and primary care on the incidence, hospitalization, adherence to treatment and mortality from HIV/AIDS. Innovative mathematical models will be created to forecast the impact of alternative scenarios and identify the best policy options to reduce the burden of the disease. Results are expected to inform national efforts to maintain progress made in controlling HIV/AIDS in Brazil and demonstrate potential strengths and weaknesses of such programs in other countries experiencing challenges in sustaining HIV/AIDS, health care, and social protection programs, including the United States.

PI_NAMEs: RASELLA, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adherence;Adult;Affect;antiretroviral therapy;beneficiary;Big Data;Brazil;burden of illness;Calibration;cohort;Communities;Country;Data;Data Set;Death Rate;Development;Dimensions;Disease;economic determinant;Economics;Epidemic;Evaluation;experience;Exposure to;Family health status;Fees;Future;Health;health data;Health Promotion;Healthcare;Heterogeneity;HIV;HIV/AIDS;Hospitalization;improved;Incidence;Individual;Infant;Injecting drug user;innovation;Intervention;Knowledge;large datasets;large-scale database;Link;Long-Term Effects;longitudinal dataset;low and middle-income countries;Maintenance;mathematical model;Measures;Medical;Medical Care Team;meetings;men who have sex with men;Methods;Modeling;models and simulation;mortality;multidisciplinary;Municipalities;Outcome;Personal Satisfaction;Persons;Physicians;Policies;Population;Prevalence;Prevention;Primary Care;Primary Health Care;programs;Qualifying;Randomized, Controlled Trials;Registries;response;scale up;sex;simulation;social;social determinants;social interventions;Social Protection;socioeconomics;Testing;Time;transmission process;treatment adherence;United States;virtual;Vulnerable Populations;Work


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Osteoporosis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative In this proposed in-vivo in-vitro project, we will develop and validate a patient-specific QCT-based computational technique to objectively estimate fracture risks associated with physical activities in the elderly. This technique can provide evidence-based recommendations for patients and clinicians on the safety of several physical activities in the short term, and will be translated into patient populations for fracture risk assessment in the long term.

PI_NAMEs: REZAEI, ASGHAR  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Activities of Daily Living;Address;Affect;age related;Applications Grants;arm;Articular Range of Motion;bone;Bone Diseases;Cadaver;career development;Cervical;Characteristics;Chest;Clinical;cohort;comorbidity;Computational Technique;Computer Models;computerized tools;Data;Defect;Deformity;Development;Elderly;Electromyography;Equilibrium;evidence based guidelines;Exercise;experience;experimental study;Failure;Finite Element Analysis;Floor;Fracture;fracture risk;Future;gait examination;Goals;Guidelines;healthy aging;human old age (65+);Image;improved;In Vitro;in vivo;Injury;kinematics;Knowledge;Lateral;Lifting;Magnetic Resonance Imaging;Measures;Mechanics;Metastatic Neoplasm to the Bone;Methods;Modeling;Motion;Movement;Muscle;Musculoskeletal Diseases;Neoplasm Metastasis;Neurologic Deficit;Neurologic Symptoms;novel strategies;older patient;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Pain;Pathologic;patient population;Patients;Persons;Physical activity;Population;pressure;Prevention;Process;Property;Quality of life;Recommendation;Research;response;Risk;Risk Assessment;risk prediction;Robot;Safety;Site;skills;Spinal;Spinal Fractures;Spinal Injuries;spine bone structure;System;Techniques;Testing;tool;Translating;Validation;Vertebral column;Weight-Bearing state;Work;X-Ray Computed Tomography

PROJECT_TITLE: A patient-specific computational technique to predict spine injury risks associated with physical activities

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The Women’s Digit is a previously developed ratcheting prosthetic finger that is sized to fit a 5th percentile to 95th percentile female hand. With no electronics or batteries, the cost, size, and complexity are reduced all while increasing reliability and durability. The amputation of full or partial fingers can cause physical, psychosocial, and economic damage to an individual. Replacement of a finger requires a mechanical design that can withstand the forces, torques, and environmental conditions of everyday life. The challenging requirements for an effective prosthetic finger have caused an absence of products for women Veterans with smaller hand sizes. This proposal seeks to address this void through the laboratory evaluation and a clinical take-home trial of the Biomechatronics Development Laboratory’s (BDL) Women’s Digit.

PI_NAMEs: WEIR, RICHARD FERGUS FFRENCH (contact)

PROJECT_TERMS: Address;Algorithms;Amputation;Amputees;Anatomy;Award;Caring;Client;Clinic;Clinical;Clinical assessments;clinical decision-making;Clinical Trials;Consensus;cost;Custom;Data;Data Analyses;design;Development;Device or Instrument Development;Devices;Digit structure;Drops;Economics;Electronics;Enrollment;Ensure;Environment;Evaluation;experience;Feedback;Female;Fingers;follow-up;Goals;Grant Review;grasp;Hand;Home;improved;Individual;Industry;innovation;Label;Laboratories;laboratory development;Life;Life Style;limb amputation;Literature;manufacture;manufacturing technology;Marketing;Mechanics;Medical;Medicine;military veteran;Mission;National Institute of Child Health and Human Development;novel;Occupational Therapist;Outcome Measure;Participant;Patients;personalized approach;Population;Production;Prosthesis;Prosthesis Design;prosthetic hand;Protocols documentation;prototype;psychologic;psychosocial;Publications;Publishing;Questionnaires;Recommendation;recruit;Request for Proposals;response;Rubber;Sample Size;satisfaction;Security;Small Business Innovation Research Grant;standard of care;Surface;System;Technology;Testing;timeline;Torque;Translating;Translations;United States National Institutes of Health;Upper Extremity;usability;verification and validation;Veterans;Weight;Woman;Women's trial;Work

PROJECT_TITLE: Artificial Digit Replacements for Women Veterans with Individual Digit Loss

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Racial minorities, ethnic minorities, and individuals with low socioeconomic status (SES) are vulnerable groups that have long faced disparities in health care access and outcomes. Voluntary bundled payments could exacerbate these disparities, particularly for lower extremity joint replacement (LEJR) for osteoarthritis, congestive heart failure (CHF), and sepsis – the most prevalent procedures and conditions with existing disparities. To inform payment policy that promotes parity, this study will examine how hospitals’ and physician groups’ participation in the largest voluntary bundled payment programs impacts access and outcomes for racial minorities, ethnic minorities, and low SES individuals.

PI_NAMEs: LIAO, JOSHUA M;NAVATHE, AMOL S (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: The effect of voluntary bundled payments on vulnerable populations

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: DAVIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: RNA editing catalyzed by the ADAR enzymes is perturbed in a variety of human diseases. In addition, siRNA and miRNA-triggered RNA interference (RNAi) pathways hold promise for the development of new therapeutic RNAs. The proposed studies will extend our basic understanding of the process of RNA editing, lead to new methods for the control of RNA editing and advance approaches for the modification and optimization of therapeutic RNAs.

PI_NAMEs: BEAL, PETER A. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: ADAR1;Address;Adenosine;Antisense Oligonucleotides;Area;Autoimmune Diseases;Award;Binding;Chemicals;Chemistry;Code;Codon Nucleotides;Complex;Coupled;design;Development;Disease;DRADA2b protein;Enzymes;gene function;Gene Silencing Pathway;Genes;Guanosine;Human;human disease;improved;inhibitor;Inosine;interest;Laboratories;Lead;Length;Malignant Neoplasms;Methods;MicroRNAs;Modification;Molecular Biology;mutant;Mutation;novel;novel therapeutics;Pathway interactions;Process;Property;Proteins;pseudotoxoplasmosis syndrome;Reagent;Regulation;Research;Research Personnel;Research Support;RNA;RNA Editing;RNA Interference Pathway;RNA Sequences;RNA-Binding Proteins;RNA-Protein Interaction;screening;skin disorder;Small Interfering RNA;Structure;targeted cancer therapy;Therapeutic;therapeutic RNA;tool;Up-Regulation;Work

PROJECT_TITLE: Defining and Controlling Protein-RNA interactions in editing and interference pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Gene therapies are an extremely powerful array of tools for treating many diseases at their source but are limited for neurological applications by the challenge of delivering them to the brain. The technology of focused ultrasound-mediated disruption of the blood-brain barrier can facilitate delivery of normally non-penetrant agents into the brain. Here we develop and validate strategies using this technology to improve delivery of gene therapies to the brain, focusing on the specific application of delivering a micro- RNA therapy for the treatment of Huntington’s disease.

PI_NAMEs: TODD, NICHOLAS E. (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;adeno-associated viral vector;Affect;Aftercare;behavior test;Biodistribution;Blood - brain barrier anatomy;Blood Volume;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain region;Capsid;cell injury;Cell Physiology;cell type;Central Nervous System;chemotherapy;Clinical;Clinical Trials;Control Groups;Data;Development;Disease;Disease Marker;Disease Progression;Dose;efficacy study;Engineering;experience;FDA approved;Focused Ultrasound;Gene Delivery;gene delivery system;gene therapy;Gene Transfer;gene-targeted therapy;Genes;Glioblastoma;Goals;Hemorrhage;Human;Huntington Disease;Huntington gene;improved;Injections;Institution;Intravenous;intravenous injection;knock-down;Macaca mulatta;Magnetic Resonance Imaging;Measures;Mediating;Microbubbles;MicroRNAs;Monkeys;Motor;mouse model;Mus;mutant;Nervous System Disorder;neuroinflammation;Neurologic;nonhuman primate;novel;optimal treatments;Organ;Outcome Measure;Patients;Penetrance;Penetration;Peripheral;Phase;pre-clinical;pressure;primary outcome;Proteins;Rattus;response;Rodent;Route;Safety;safety assessment;secondary outcome;Site;Source;Specificity;Structure;System;targeted treatment;Technology;technology platform;Testing;Therapeutic;therapeutic miRNA;Time;Tissues;tool;Toxic effect;Translating;Trauma;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment strategy;Validation;vector;Viral;Viral Packaging;Viral Vector;Work

PROJECT_TITLE: Improved Delivery of Gene Therapies to the Central Nervous System by Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioids;Pain Research;Prescription Drug Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE While medical cannabis has been approved in many states for the treatment of pain, the effects of medical cannabis on prescription opioid/benzodiazepine use patterns and health outcomes at the patient-level has not been fully examined to date. Additionally, adults aged ≥50 represent a population that is vulnerable to potential detrimental effects of co-using both cannabis products and opioids/benzodiazepines. This study aims to examine the impact of medical cannabis on changes in prescription opioid/benzodiazepine use and health outcomes among older adults using innovative data linkage.

PI_NAMEs: RADHAKRISHNAN, RAJIV  (contact);RHEE, TAEHO GREGORY;WILKINSON, SAMUEL

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;age group;aged;American;Anxiety;Benefits and Risks;Benzodiazepines;Cannabis;Cannabis policy;Censuses;Cessation of life;comorbidity;Confusion;Connecticut;Consumption;Data;Data Aggregation;Data Linkages;Drops;Drug Prescriptions;Drug usage;Electronic Health Record;Emergency department visit;Expenditure;falls;FDA approved;Future;Health;health care service utilization;Health Service Area;Healthcare;Healthcare Systems;Hospitalization;Impaired cognition;Incidence;Individual;innovation;Legal;marijuana legalization;marijuana use;marijuana use disorder;Marketing;Medical;Medical Marijuana;Medicare;Monitor;mortality;multiple chronic conditions;older adult;Opioid;opioid epidemic;Outcome;Overdose;overdose death;Pain;Pain Disorder;Pain management;pain symptom;Patients;Pattern;permissiveness;Pharmaceutical Preparations;Policies;Policy Maker;Population;Predisposition;prescription monitoring program;prescription opioid;Prevalence;prevent;programs;Reporting;Respiratory Failure;Risk;Scoring Method;Sedation procedure;service utilization;Sleep Disorders;Sleeplessness;Statutes and Laws;stem;Surveys;System;Time;treatment services;trend;United States;Vulnerable Populations;Woman;Women's mortality

PROJECT_TITLE: Impact of cannabis legalization on prescription drug use and health outcomes in Connecticut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The Pediatric Injury and Violence Prevention Student Internship Training Program (INSIGHT) is an intensive, eight-week interdisciplinary and rigorous research education course in pediatric injury and violence prevention for upper-level undergraduate students. Trainees are matched to research faculty experts in pediatric trauma and injury control, and all work involves a health equity lens. Research areas include elucidating risk factors and outcomes of pediatric injury and violence, community engaged research in injury and violence prevention, acute and chronic care of injured patients, trauma outcomes, and interventions to return the injured child and adolescent to full potential.

PI_NAMEs: PATEL, KUSHANG  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acute care;Address;Adolescent;Affect;Area;Award;Black race;career;Cause of Death;Cessation of life;Childhood Injury;Chronic Care;college;Communication;Communities;community engaged research;Course Content;Critical Illness;Curriculum Management System;Data Analyses;data cleaning;Data Science;data visualization;Database Management Systems;Development;disability;Education;education research;Educational Curriculum;Educational process of instructing;Enrollment;equity, diversity, and inclusion;experience;Exposure to;Faculty;follow-up;Funding;Future;Generations;Goals;health equity;health inequalities;Health Occupations;higher education;Hispanic;Inequity;injured;Injury;injury prevention;innovation;Instruction;Internships;Intervention;Learning;Link;Manuscripts;Measures;Mentors;Mentorship;Methods;mindfulness;Minority Groups;minority student;Mission;National Institute of Child Health and Human Development;Outcome;Patients;Pediatric Research;pediatric trauma;peer;Performance;Personal Satisfaction;Policies;Population;Positioning Attribute;posters;Preparation;Prevention Research;programs;Public Health;Publications;recruit;Research;research and development;Research Design;Research Ethics;research faculty;Research Methodology;Research Personnel;Research Project Grants;response;Review Literature;Risk Factors;Schedule;skills;skills training;Structure;student training;Students;success;symposium;Syndrome;technical writing;Time Management;Training;Training Programs;Trauma;trauma care;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Violence;violence prevention;Washington;Woman;Work;workforce needs

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  Repeat expansions disorders such as Huntington’s Disease and Friedreich Ataxia are severely debilitating rare neurodegenerative disorders, for which, despite the underlying genetic mutations being known for over 20 years now, there are still no effective therapies available, suggesting that novel approaches are necessary. There is growing evidence that somatic repeat expansion is a shared hallmark across the different repeat expansion disorders and that this may contribute to disease onset and progression, supporting further investigation of repeat expansion mechanism(s) as potential therapeutic targets. This study is aimed at: 1) identification of non- invasive samples that can be used as potential biomarkers of disease; 2) development of novel methodology to better size and quantify repeat instability; 3) discovery and characterization of genetic modifiers of somatic repeat expansions, 4) development of novel therapeutics targeting the repeat expansion process as a potential universal treatment for these devastating disorders.

PI_NAMEs: MOURO PINTO, RICARDO  (contact)

PROJECT_TERMS: Address;Affect;Alleles;Antisense Oligonucleotides;base editor;Biological Markers;Biopsy;Brain;CAG repeat;Candidate Disease Gene;candidate validation;Cell model;Cells;Child;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Corpus striatum structure;CRISPR therapeutics;Development;Disease;Disease Progression;DNA Repair Gene;DNA Repair Pathway;DNA Repeat Expansion;DNA Sequence Alteration;Drug Targeting;effective therapy;efficacy testing;endonuclease;Endonuclease I;Exhibits;Expanded DNA Repeat;experimental study;Fibroblasts;Friedreich Ataxia;Genes;Genetic;genome wide association study;Goals;Heart;Human;Huntington Disease;in vivo;insight;intergenerational;Investigation;Knock-out;Knowledge;Length;Liver;Mendelian disorder;Methodology;Methods;minimally invasive;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuromuscular Diseases;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;Oligonucleotides;Onset of illness;Parents;Pathogenicity;Pathway interactions;Patients;Phenotype;potential biomarker;Process;promoter;Reagent;Reporting;Research;RNA Splicing;Role;Sampling;Spinal Ganglia;stool sample;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissues;tool;Translating;Trinucleotide Repeat Expansion;Trinucleotide Repeats;Validation

PROJECT_TITLE: Somatic Repeat Expansions as a Therapeutic Target for Trinucleotide Repeat Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Palliative Care

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This proposal will have a significant public health impact because it will (1) increase mentoring of new clinical investigators dedicated to research that addresses deficiencies in the quality of care for a burgeoning population of older adults with serious illness and (2) it will inform geriatric palliative care interventions to improve quality of life and goal-concordant care for older adults with advanced cancer by aligning treatments with patient priorities and addressing age-related concerns.

PI_NAMEs: SCHENKER, YAEL  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;Age;age related;Aging;Attention;Award;Behavior Therapy;care delivery;care seeking;career;career development;Caregiver Burden;Caregivers;Caring;Chronic;Clinical;Clinical Investigator;Cognition;Collaborations;Communication;Computerized Medical Record;Data;Data Set;Dedications;design;Diagnosis;Discipline;Disease;Educational Curriculum;Elderly;Enrollment;Environment;experience;Faculty;Family Caregiver;Fostering;Foundations;Funding;Future;Geriatric Assessment;Geriatrics;Goals;Grant;human old age (65+);improved;improved outcome;Infrastructure;innovation;Intervention;Intervention Studies;Intervention Trial;Investigation;Learning;longitudinal dataset;Malignant Neoplasms;medical specialties;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;mindfulness;Modeling;Morbidity - disease rate;next generation;novel;Office Nursing;older adult;older patient;Older Population;Oncology;Outcome;outreach;palliative;Palliative Care;Patients;Personal Satisfaction;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Pragmatic clinical trial;preference;professor;programs;Public Health;Quality of Care;Quality of life;Reporting;Research;Research Personnel;Research Training;resilience;Resources;Role;self-compassion;skills;Social support;student mentoring;Students;Techniques;Testing;therapy design;therapy development;Thinking;Time;Training;trial design;Universities;Update;Visit;Work

PROJECT_TITLE: Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MAS

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa, an opportunistic human pathogen that causes a variety of difficult or impossible to resolve infections, uses quorum sensing to control virulence, and quorum sensing has become a target for development of novel antimicrobials. Efforts to develop quorum-sensing inhibitors as therapeutics will rely on a better understanding of the role of quorum sensing in virulence and on a basic understanding of the selective pressures leading to quorum-sensing control of gene expression in P. aeruginosa. Studies of P. aeruginosa quorum sensing are also providing fundamental understanding of the molecular underpinnings of cooperation.

PI_NAMEs: GREENBERG, EVERETT P (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: antimicrobial;Biological;Biological Phenomena;biological research;Biotechnology;Cell Communication;Cell Density;Cells;Chronic;Communication;Complex;Cooperative Behavior;Costs and Benefits;Cystic Fibrosis;Development;Elements;Gene Expression;Generations;genetic approach;Genetic Diseases;homoserine lactone;Human;human pathogen;In Vitro;Infection;inhibitor;interest;Knowledge;Learning;Lung infections;member;microbial community;Molecular;Molecular Genetics;novel;pathogen;Persons;Play;Population;Population Biology;pressure;Pseudomonas aeruginosa;quorum sensing;Research;Role;Signal Transduction;Specificity;Study models;System;Techniques;Therapeutic;Virulence;Work

PROJECT_TITLE: Quorum sensing in Pseudomonas aeruginosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: We have discovered that MYCN amplification and ATRX-mutations are synthetic lethal in neuroblastoma (NB). In this project, we will suppress ATRX pathway function in MYCN amplified NB and mimic key aspects of MYCN amplification in ATRX-mutant tumors. Discoveries from this study will be directly translated into clinical trials in children with NB at St. Jude.

PI_NAMEs: DYER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acceleration;Affect;Age;Antibodies;antibody-dependent cell cytotoxicity;ATRX gene;Binding;Biogenesis;Biology;Cephalic;chemotherapy;Child;Childhood Solid Neoplasm;Clinical Trials;clinically relevant;Complex;Cyclophosphamide;cytokine;Data;Databases;Defect;design;Diagnosis;disorder risk;DNA;DNA biosynthesis;DNA Damage;DNA Polymerase I;DNA Repair;Dose;Drug Kinetics;drug sensitivity;efficacy testing;epigenomics;Evaluation;experience;G-Quartets;Generations;Genomics;Goals;Government;Growth;Health;high risk;Histones;Human;Human Cell Line;Immunotherapy;improved;improved outcome;in vivo;induced pluripotent stem cell;inhibitor;Interleukin-15;Interleukin-2;Malignant Neoplasms;Mediating;Metabolic;mitochondrial dysfunction;Molecular;Molecular Chaperones;Molecular Diagnostic Testing;molecular targeted therapies;mouse model;multidisciplinary;mutant;Mutation;MYCN gene;Natural Killer Cells;neoplastic cell;Neuroblastoma;neuroblastoma cell;novel therapeutic intervention;Oncogene Activation;Oncogenes;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;Persons;Phase I/II Clinical Trial;Play;Positioning Attribute;Preclinical Testing;prevent;Process;Prognosis;Publishing;Reactive Oxygen Species;Recurrence;Reporting;Research;Research Project Grants;Research Proposals;response;Ribosomes;RNA;Role;Saint Jude Children's Research Hospital;Schedule;Series;Solid Neoplasm;Standardization;Stress;Structure;Testing;Therapeutic;Topotecan;Toxic effect;Translating;Translational Research;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Genes

PROJECT_TITLE: Novel Therapeutic Approaches for the Treatment of Neuroblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Caveolins are an unusual family of membrane proteins that form small flask-shaped structures at the surface of cells. By ways that are not yet fully understood, these structures regulate normal physiological functions such as lipid storage and cardiovascular function, and when defective they can cause the development of multiple diseases including cancer, pulmonary arterial hypertension, and muscular dystrophy. We will use a combination of structural, biochemical, biophysical, cell biological, and computational approaches to investigate how caveolins function at the cellular level.

PI_NAMEs: KENWORTHY, ANNE K (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adipose tissue;base;Biochemical;Biogenesis;Biological;Biological Assay;Biological Process;biophysical properties;Biophysics;Body System;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Caveolae;caveolin 1;caveolin-2;caveolin-3;Caveolins;Cell Adhesion;Cell Differentiation process;Cell membrane;cell motility;Cell Physiology;Cell surface;cell type;Cells;Cholesterol;Complex;Cryoelectron Microscopy;Cytoplasm;Data;Defect;Development;Disease;Electron Microscopy;Exhibits;Family;Family member;flasks;Geometry;Heart;Homeostasis;Homo;Human;In Vitro;insight;Intracellular Transport;Investigation;Knowledge;Link;Lipids;Lipodystrophy;Lung;Malignant Neoplasms;Mechanical Stress;mechanotransduction;Mediating;Membrane;Membrane Biology;membrane model;Membrane Proteins;Metabolism;Modeling;Molds;Molecular;molecular dynamics;Morphology;Mus;Muscle;Muscular Dystrophies;Mutation;Natural Selections;Nature;particle;Pathway interactions;Physiological;Physiology;Play;Process;Property;protein function;Proteins;Protomer;pulmonary arterial hypertension;pulmonary function;Research Personnel;Resolution;Role;sensor;Shapes;Side;Signal Pathway;Signal Transduction;Structure;Surface;Systemic disease;Testing;Tissues;trafficking

PROJECT_TITLE: Structure and Function of Non-Conventional Caveolins


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Neurosciences;Osteoarthritis;Pain Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Older persons are more likely to suffer from chronic pain than younger people, and the prevalence of persistent pain increases with age. There is strong evidence for the decline of endogenous pain modulatory function with age. This decline may predispose older adults to an increased risk of chronic pain conditions, such as osteoarthritis (OA), a chronic pain condition that disproportionately affects the aged population, especially elderly women. In this project, we will explore brain circuits that underlie age-related changes in descending pain modulatory function and the mechanistic links between dysfunctional pain modulatory systems and chronic OA pain in the aged population. Specifically, we will examine whether enhancing the strength of specific brain circuitries mediating endogenous pain modulation, either experimentally or through exercise, can improve OA pain outcomes in aged populations. Findings of this project will stimulate progress toward the development of novel evidence-based pain treatment strategies for older adults.

PI_NAMEs: RO, JIN Y (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Absence of pain sensation;Adult;Affect;Age;age difference;age effect;age related changes;age related decline;aged;Aging;aging population;Animal Model;Anterior;Area;Attenuated;Back;Behavioral Paradigm;Brain;brain circuitry;Chronic;chronic pain;chronic pain management;chronic painful condition;cingulate cortex;clinical pain;clinical translation;conditioned pain modulation;Data;Degenerative polyarthritis;Development;diffuse noxious inhibitory control;Elderly;Elderly woman;evidence base;Evidence based treatment;Exercise;experience;Female;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Human;Hyperalgesia;imaging study;Impairment;improved;indexing;insight;Knowledge;late life;Link;male;Measures;Mechanics;Mediating;Meta-Analysis;Microinjections;midbrain central gray substance;Morphine;Naloxone;National Health Interview Survey;neural;Neurons;novel;older adult;Older Population;optimal treatments;osteoarthritis pain;Outcome;Pain;Pain Disorder;pain inhibition;Pain management;pain outcome;pain processing;Pain Research;Persistent pain;Persons;pharmacologic;Pharmacological Treatment;Phase;Population;pre-clinical;Pre-Clinical Model;Prevalence;Primary Hyperalgesias;Psychophysics;Rattus;Reporting;response;Rest;Risk;Role;scale up;sex;System;tool;treatment strategy;Validation;Woman;Work

PROJECT_TITLE: Age-related decline in endogenous pain modulation and its impact on osteoarthritis pain

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Diabetes self-management education and support can help people living with diabetes, however it is underutilized. This project is highly relevant to public health as it will assess the impact of referral reminders for providers and peer support for patients to increase use of this beneficial program.

PI_NAMEs: DONAHUE, KATRINA E (contact);YOUNG, LAURA A

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Address;adequate sleep;Age;Blood Glucose;Caring;Case Manager;Clinical;clinical decision support;clinical encounter;Communities;coping;design;diabetes education;Diabetes Mellitus;diabetes self-management;Diagnosis;Diet Modification;Disease;Distress;Education;Electronic Health Record;electronic health record system;Enrollment;Ethnic Origin;evidence base;Exercise;Feasibility Studies;food insecurity;foot;Future;glucose monitor;glycemic control;Goals;hazard;Health;Health behavior change;health care settings;health literacy;Health Personnel;healthcare burden;Healthcare Systems;healthy lifestyle;Hour;Housing;improved;Individual;Institution;Insurance;Intervention;Interview;Knowledge;Learning;Life;Life Style;longitudinal analysis;medical specialties;member;Methods;Morbidity - disease rate;mortality;Motivation;novel;Observational Study;Outcome;Participant;patient population;patient-level barriers;Patients;peer;peer support;Persons;Pharmaceutical Preparations;Physicians;pragmatic randomized trial;Predictive Factor;Primary Care;primary care clinic;primary care clinician;Probability;programs;Provider;Public Health;Qualifying;Race;Randomized;Recommendation;referral services;Research Design;Resources;response;secondary outcome;Self Care;Self Efficacy;Self Management;Services;skills;Skin Care;social;social health determinants;Social support;Specialist;Structure;support tools;Testing;Time;tool;Training;Training Support;Transportation;treatment as usual;trial design;Uncertainty;unconscious bias;uptake;Work

PROJECT_TITLE: Novel Interventions to Increase Uptake of Diabetes Self-Management Support Training within Primary Care


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: Chronic pain is a prevalent, costly, and disabling condition with multidimensional impacts on people's lives. Integrated, accessible, and scalable behavioral treatments are needed to reduce pain and prescription opioid iatrogenics. This K24 award will permit the PI to expand her efforts in mentoring junior investigators in patient-oriented research and to conduct impactful research to alleviate the suffering of people with chronic pain on the continuum of opioid use disorder.

PI_NAMEs: DARNALL, BETH DENISE (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Acceleration;active control;addiction;Address;Aftercare;Alcohols;Applications Grants;arm;Behavior;Behavior Therapy;Behavioral;Behavioral Medicine;Board Certification;career;career development;Caring;chronic pain;Clinical;Clinical and Translational Science Awards;Collaborations;Communities;comorbidity;cost;craving;Data;Dedications;design;Development;Development Plans;digital;digital health;digital intervention;digital treatment;Dimensions;Disabling condition;Distress;Doctor of Philosophy;Educational Intervention;Electronics;empowerment;Enrollment;Ethics;Faculty;Fellowship;Fellowship Program;Funding;Future;Goals;Grant;Group Meetings;Health education;Health Service Area;high risk;Iatrogenesis;implementation science;Individual;Informal Social Control;innovation;International;Intervention;Leadership;Learning;Learning Skill;lectures;literate;marijuana use;Measures;medical schools;Medicine;meetings;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;National Institute of Drug Abuse;next generation;Operative Surgical Procedures;Opioid;opioid misuse;opioid policy;opioid tapering;opioid use;opioid use disorder;Outcome;Pain;pain catastrophizing;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;pain relief;Paper;Participant;patient engagement;patient oriented;patient oriented research;Patients;Persons;Physicians;Population;prescription opioid;prescription opioid misuse;Prisons;Process;programs;psychologic;Psychology;Randomized;Randomized, Controlled Trials;recruit;Relaxation;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;response;responsible research conduct;Risk;role model;rural area;Sampling;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;Series;Sex Differences;skills;Source;Structure;Substance Use Disorder;success;Surveys;Technology;Testing;therapeutic opioid;Time;Training;undergraduate education;Underserved Population;United States Indian Health Service;United States National Institutes of Health;Universities;virtual;Writing

PROJECT_TITLE: Research and Mentoring in Innovative Patient Oriented Pain and Opioid Science

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Microbiome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Billions suffer from parasitic infections or allergic diseases that are regulated by type 2 immune responses in the intestine. The goals of this proposal are to understand the relationship between intestinal epithelial cells, microbiota, and type 2 immune responses. The outcomes of these studies will benefit human health because they will inform the design of new approaches for combatting allergic inflammation and improving intestinal immunity to fight infection.

PI_NAMEs: ESHLEMAN, EMILY M. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Allergic;Allergic Disease;Allergic inflammation;Area;Butyrates;Calibration;career;career development;Cell Count;Cell Differentiation process;Cell Lineage;Cells;Chromatin;Chronic;Collaborations;commensal bacteria;cytokine;Data;design;Development;Development Plans;Disease;disease model;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Fibrosis;fighting;Food Hypersensitivity;Gastrointestinal tract structure;Gnotobiotic;Goals;gut inflammation;gut microbiota;HDAC3 gene;Health;helminth infection;Helminths;Histone Deacetylase Inhibitor;Homeostasis;host microbiota;Human;Hypersensitivity;Immune response;Immune System Diseases;Immunity;immunoregulation;improved;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;insight;Intervention;Intestinal Diseases;intestinal epithelium;Intestines;Link;Mediating;Mentors;Mentorship;Metagenomics;Microbe;microbial;microbiota;Modeling;Modernization;Molecular;mouse model;Mucosal Immune Responses;Mus;novel;novel strategies;novel therapeutic intervention;Organoids;Outcome Study;Parasitic infection;pathogen;Pathogenesis;Pathway interactions;Pediatric Hospitals;prevent;Production;Regulation;Research;Research Personnel;response;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Specialized Epithelial Cell;stem cells;Stimulus;Testing;tissue repair;tool;Training;Transgenic Mice;Transgenic Organisms;Translating;Work

PROJECT_TITLE: Microbial regulation of intestinal tuft cell homeostasis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative  Natural product chemical space (NP space) embodies small molecules that are preoptimized for organismic compatibility. This proposal describes the invention of new chemistry to access, interrogate and modify secondary metabolites that already demonstrate neuromodulatory or antiproliferative phenotypes. These studies lay the foundation for the development of new tools to study human disease and new therapeutics to alleviate it.

PI_NAMEs: SHENVI, RYAN ASHOK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Unusual Pharmacophores and New Tools for Cross-Coupling

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Fibrosis, or scarring, in the heart can lead to heart dysfunction and irregular heart rhythms. We identified a novel mechanism to regulate scarring in the heart that can be useful to treat fibrosis. We propose to define this mechanism of action between different cell types in the heart and test whether treating fibrosis can improve heart function.

PI_NAMEs: DEMONBREUN, ALEXIS R.;MCNALLY, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Alleles;Amino Acids;Antibodies;Arrhythmia;Binding;Binding Proteins;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;cardioprotection;Cell Differentiation process;cell growth;cell growth regulation;cell type;Cells;Chronic;Chronic Disease;Cicatrix;Communication;coronary fibrosis;Deposition;Disease Progression;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fibroblasts;Fibrosis;Genes;Genetic;Genotype;Goals;Haplotypes;Heart;Heart Diseases;heart function;Heart Injuries;heart rhythm;Human;Human Engineering;human induced pluripotent stem cells;Impairment;improved;in vivo;in vivo Model;induced pluripotent stem cell derived cardiomyocytes;injured;Injury;Link;Mechanics;Mediating;migration;Modeling;Mouse Strains;Mus;Muscular Dystrophies;Myocardial dysfunction;novel;Pathogenesis;Pattern;Positioning Attribute;Predisposition;Proliferating;Proteins;Proteolysis;Regulation;Resistance;Risk;risk variant;Role;Sarcolemma;scaffold;Signal Transduction;Skeletal Muscle;Surface;Testing;Therapeutic;Tissues;transcriptome;Transforming Growth Factor beta;Work

PROJECT_TITLE: Extracellular matrix regulation of cellular crosstalk in cardiac fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Autoimmune Disease;Kidney Disease;Lupus

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE In lupus nephritis, renal tubular epithelial cell injury is a better predictor of progression to end stage kidney disease than glomerular injury. Proximal tubular epithelial cells of the kidney accumulate iron in lupus nephritis which can induce Ferroptosis, an iron dependent form of regulated cell death. We want to understand the contribution of ferroptosis in augmenting proximal tubular epithelial cells pathology in lupus nephritis and use this information to repurpose ferroptosis inhibitors as novel adjunct therapy for lupus nephritis.

PI_NAMEs: MOREL, LAURENCE ;SCINDIA, YOGESH  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adverse effects;Animals;Antibodies;Antigen-Antibody Complex;Attenuated;Autoantibodies;Biological;Bone Marrow;CD4 Positive T Lymphocytes;Cell Death;cell injury;Cell surface;Cells;Chimera organism;Coenzyme A Ligases;cohort;Complex;Congenic Mice;Cystine;Data;Dependence;Deposition;design;Disease;Dose;End stage renal failure;Enzymes;Epithelial Cells;Etiology;Exposure to;Family;Family member;Foundations;Generations;Genetic Markers;Genetic Transcription;Glomerulonephritis;Glutathione;Human;Immune Complex Glomerulonephritis;Immunoglobulin G;Immunoglobulins;Immunosuppression;Immunosuppressive Agents;Impairment;improved outcome;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;Iron;Kidney;kidney epithelial cell;Kidney Failure;Lead;Lipid Peroxidation;lipidomics;LoxP-flanked allele;Lupus;Lupus Nephritis;lupus prone mice;Mediating;Medical;member;Modeling;Molecular;mouse model;mRNA Precursor;Mus;Nephritis;nephrotoxicity;neutralizing antibody;new therapeutic target;novel;novel strategies;Organ;Outcome;oxidation;Pathology;Pathway interactions;Patients;Polyunsaturated Fatty Acids;Predisposition;promoter;protein biomarkers;Proteinuria;Recycling;Renal glomerular disease;Renal tubule structure;Resistance;Sampling;Serum;solute;Sorting;System;Systemic Lupus Erythematosus;Testing;Therapeutic;therapeutic target;Treatment Efficacy;Tubular formation;uptake

PROJECT_TITLE: Targeting ferroptosis in renal tubular epithelial cells to improve outcomes of lupus nephritis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Lupus;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Precision Medicine

PHR: Project Narrative Systemic lupus erythematosus (SLE) is a heterogeneous systemic condition associated with serious morbidity and premature mortality, yet treatment options are limited. There is uncertainty regarding the optimal use of the two FDA-approved lupus medications, hydroxychloroquine and belimumab, due in part to the risks of adverse treatment effects including hydroxychloroquine retinopathy and infection. This Career Development Award focuses on applying advanced clinical epidemiology and patient-centered decision science to integrate personalized risks of potential harms and benefits with patient preferences to guide the personalized, patient- centered use of key lupus medications, including specifically the optimal dose of hydroxychloroquine in SLE care.

PI_NAMEs: JORGE, APRIL  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Academy;adjudication;Adverse effects;adverse outcome;Award;Azathioprine;belimumab;Biological;Cardiovascular system;care outcomes;Caring;catalyst;Clinical;clinical decision-making;clinical epidemiology;Clinical Investigator;Clinical Research;cohort;comorbidity;conventional dosing;data access;data-driven model;Decision Analysis;Decision Making;Disease;Doctor of Philosophy;dosage;Dose;Electronic Health Record;Environment;Epidemiologic Methods;Equilibrium;Event;experience;experimental study;FDA approved;Fellowship;Flare;Foundations;Funding;General Hospitals;General Population;Goals;Guidelines;Harm Reduction;Heterogeneity;Hospitalization;Hydroxychloroquine;Immunosuppressive Agents;improved;improved outcome;Infection;infection risk;innovation;instructor;Internal Medicine;K-Series Research Career Programs;Life;Lupus;Machine Learning;machine learning prediction algorithm;Maryland;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methodology;Methotrexate;Modeling;Morbidity - disease rate;mortality;mortality risk;Mycophenolate;novel;Ophthalmology;Oral;Organ;Outcome;Paper;Patient Compliance;patient oriented;patient oriented research;Patient Preferences;Patient Recruitments;patient stratification;Patients;Peer Review;personalized medicine;Pharmaceutical Preparations;Pharmacoepidemiology;Physicians;Positioning Attribute;predictive modeling;preference;Premature Mortality;Recommendation;renal damage;Research;Research Methodology;Research Personnel;Residencies;Retinal Diseases;Rheumatology;Risk;Risk Factors;risk prediction;risk stratification;SARS-CoV-2 infection;Science;Scientist;severe COVID-19;Severity of illness;skills;Subgroup;Systemic Lupus Erythematosus;therapy adverse effect;Training;Training Activity;Translational Research;Treatment outcome;trend;Uncertainty;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: A Personalized, Patient-Centered Approach to Optimizing Lupus Care


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Advanced peripheral neuroprostheses will require high-density (HD) interconnections that are enabled by our proposed research effort. These systems will contribute to the distribution of new clinical interventions for Veterans based on effective life enhancing technology to the veteran population, in whom lower extremity paralysis or weakness is common. Specifically, motor nerve dysfunction due to stroke or incomplete spinal cord injury can create debilitating conditions that affect a Veteran's ability to walk and engage in physical activity. HD stimulation and in-line connector technology for walking assistance has the potential to enhance functional independence by providing patients with a means to maneuver. Combat- related amputations have been steady, too, and new prosthetic technology for amputees can restore natural sensations in amputated limbs; our connectors help miniaturize such systems.

PI_NAMEs: GBUR, JANET L (contact)

PROJECT_TERMS: Acceleration;Affect;Amendment;Amputation;Amputees;Animal Model;Animals;Artificial Implants;biomaterial compatibility;Chronic;Clinical;Clinical Research;Clinical Trials;co-clinical trial;combat;Custom;Data;density;design;Development;Devices;devices for disabled persons;Documentation;electric impedance;Electrodes;Encapsulated;Enhancement Technology;Equipment Malfunction;Esthesia;Experimental Designs;experimental study;Exposure to;fabrication;Family Felidae;FPS-FES Oncogene;Functional disorder;functional electrical stimulation;functional independence;Funding;Future;gait rehabilitation;Generations;Goals;Health;Hip region structure;Histologic;Implant;implantable device;implantation;improved;In Vitro;in vitro testing;interoperability;Intervention;Knee;Laboratories;Life;limb amputation;Location;Mechanics;Medical Device;Methods;military veteran;miniaturize;Mission;Modeling;Monitor;Motor;Muscle;nanoscale;Nerve;neural;neural prosthesis;Neurologic Deficit;neurological rehabilitation;neuroprosthesis;next generation;Operative Surgical Procedures;Paraplegia;Partner in relationship;Pathologic;Patient Care;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;Phantom Limb;Physical activity;post stroke;Postoperative Period;Preclinical Testing;Process;process optimization;programs;Prosthesis;Publishing;Qualifying;recruit;Rehabilitation therapy;Research;Research Personnel;Running;Safety;Saline;Science;seal;Sensory;sensory feedback;sensory system;silicon carbide;Site;Solid;Spinal cord injury;Sterilization;Stroke;System;Techniques;Technology;Test Result;Testing;Tissues;Update;Upper Extremity;Validation;Variant;Vendor;Veterans;Walking;Work

PROJECT_TITLE: Optimization & Pre-clinical Testing of Implantable, In-Line High Density 32-Channel Connector


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related

PHR: NARRATIVE: In this proposal, we will develop and characterizing a platform of gene engineered syngeneic immunosuppressive and active GBM therapeutic tumor cells (ThTC) and assess their therapeutic efficacy of ThTC in primary and recurrent GBM models of resection. We will also develop therapeutic patient derived human resected tumor cells (hThTC) and test them in mouse GBM models derived from primary and recurrent resected GBM patients. The developed agents and strategies will be designed to be clinically translatable and should have a major impact in translating cell based therapies for a broad spectrum of metastatic tumors.

PI_NAMEs: SHAH, KHALID A (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Active immunity;adaptive immunity;Animals;anti-tumor immune response;Autologous;Back;Behavior;Boston;Brain Neoplasms;cancer cell;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;cell killing;Cell Line;Cell Therapy;Cells;Circulation;Clinical;clinical translation;Collaborations;CRISPR/Cas technology;cytotoxic;Cytotoxic agent;Data;design;efficacy evaluation;Encapsulated;Engineered Gene;Engineering;Ensure;evidence base;Excision;Exhibits;Extracellular Matrix;gene editing technology;Genes;Genetic Engineering;Glioblastoma;Glioma;Goals;granulocyte;Home;Homing Behavior;Human;humanized mouse;imaging agent;imaging biomarker;Immune;immune modulating agents;Immunity;Immunization;Immunocompetent;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;in vivo;Interferon-beta;Knock-out;Ligands;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Metastatic/Recurrent;Modality;Modeling;mouse model;Mus;Natural Immunity;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;patient prognosis;Patients;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;Proteins;Publishing;receptor;recruit;Recurrence;Recurrent tumor;Resected;Residual Neoplasm;Residual state;Resistance;Safety;Science;Site;Solid Neoplasm;stem cells;Surgically-Created Resection Cavity;temozolomide;Testing;Therapeutic;therapeutic genome editing;Translating;Treatment Efficacy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Stem Cells;vaccination strategy

PROJECT_TITLE: Gene Edited and Engineered Tumor Cell Therapeutics for Cancer

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Services;Heart Disease;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Patient Safety;Prevention;Schizophrenia;Serious Mental Illness;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Younger adults with severe mental illness (SMI) seldom receive targeted, evidence-based strategies intended to prevent diabetes and related cardiovascular complications, despite heightened risk for cardiometabolic disease. Clinical Decision Support (CDS) tools are computer algorithms that use patients’ data, predictive analytics, and clinical evidence to help patients and clinicians navigate complex treatment decisions. The proposed research will create the foundations for a novel CDS tool seeking to promote cardiometabolic disease prevention care for adults with SMI under age 45 who have recently started antipsychotic medications (a diabetes risk factor) through the following activities: (1) development of diabetes risk prediction models based on > 50,000 electronic health records for individuals in this population; (2) engagement of patient, clinician, and health system leader stakeholders in designing CDS tool risk/recommendation messaging and implementation pathways; and, (3) testing the feasibility, acceptability, and preliminary clinical effects of using CDS tool messaging within an existing telehealth population management program serving adults with SMI.

PI_NAMEs: ITURRALDE, ESTI  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adult;Age;Antipsychotic Agents;Behavioral;Bipolar Disorder;California;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;career development;Caring;Cessation of life;Clinical;clinical care;Clinical Data;clinical decision support;clinical effect;Clinical Trials Design;Cluster randomized trial;Complex;Computational algorithm;Conduct Clinical Trials;Counseling;Data;data resource;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;disorder prevention;Doctor of Philosophy;Electronic Health Record;Ethnic Population;evidence base;Evidence based intervention;experience;Face;feasibility testing;feasibility trial;Feedback;Fellowship;field study;Foundations;Funding;Future;General Population;Goals;Guidelines;Health;health care delivery;Health system;Healthcare Systems;implementation science;improved;Individual;individualized medicine;insight;Intervention;intervention participants;K-Series Research Career Programs;Laboratories;Learning;Life Style;Link;Major Depressive Disorder;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metabolic syndrome;Methods;Michigan;Minnesota;Modeling;National Institute of Mental Health;Non-Insulin-Dependent Diabetes Mellitus;novel;obesogenic;Outcome;Participant;Pathway interactions;patient engagement;Patient-Centered Care;Patients;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Pilot Projects;pilot test;Population;population based;population health;Pragmatic clinical trial;Predictive Analytics;predictive modeling;preference;premature;prevent;Prevention;Prevention strategy;Process;programs;Psychological Factors;Psychologist;Psychopharmacology;Psychotic Disorders;Public Health;Qualitative Methods;racial diversity;racial population;rapid weight gain;Recommendation;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction model;Risk Reduction;Science;Services;severe mental illness;side effect;Site;smoking cessation;smoking initiation;stakeholder perspectives;success;support tools;Target Populations;telehealth;telehealthcare;Testing;therapy design;tool;Training;Training Support;Translating;Translations;treatment as usual;uptake;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Optimizing Care to Prevent Diabetes and Promote Cardiovascular Health Among Younger Adults with Severe Mental Illness


ORG_CITY: NEW YORK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Nurses are burdened with the amount of data they need to document in electronic health records. We will analyze how nursing documentation changed when they were not required to document in specific ways during the COVID-19 pandemic. This project will help us improve documentation so nurses can focus more on patient care.

PI_NAMEs: ROSSETTI, SARAH COLLINS (contact);YEN, PO-YIN

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Essential Nurse Documentation: Studying EHR Burden during COVID-19 (ENDBurden)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This study will investigate the relationship between surgical training, early career surgeon performance and patient safety. The results of this study can ultimately be used to implement new training standards to ensure that all early career surgeons are providing safe care. This evidence is urgently needed to safeguard the health of millions of American patients.

PI_NAMEs: GEORGE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Early career surgeon performance - a patient safety blind spot

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose to investigate the mechanisms of action and therapeutic potential of NSD3 in the regulation of Lung Squamous Cell Cancer pathogenesis in vivo in pre-clinical models of the disease.

PI_NAMEs: GOZANI, OR P.;MAZUR, PAWEL K. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: 3q26;8p11;Accounting;Biochemical;Cancer Etiology;Cancer Model;Cells;Cessation of life;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Trials;clinically actionable;Data;Development;Diagnosis;Disease;disease model;DNA methylation profiling;driver mutation;drug candidate;Drug Targeting;Enzymes;Epigenetic Process;epigenomics;Epitopes;Evolution;experimental study;FGFR1 gene;FGFR1 Gene Amplification;gain of function;Gene Amplification;Generations;Genes;Genetic;Genomic Segment;Goals;Heterogeneity;Histologic;Histone H3;histone methyltransferase;histone modification;Human;human model;improved;in vivo;inhibitor;insight;Knockout Mice;Lysine;Maintenance;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;Methylation;Methyltransferase;Modeling;Molecular;mortality;mouse model;multiple omics;Mus;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutics;Oncogenic;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Penetrance;pre-clinical;Pre-Clinical Model;recombinase;Regulation;Research;Resolution;Role;Sampling;Squamous Cell Lung Carcinoma;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;TP53 gene;transcriptomic profiling;tumor;tumor heterogeneity;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;United States;Validation;Work

PROJECT_TITLE: Role of NSD3 in regulation of cancer pathogenesis

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ORG_STATE: FL

PHR: Myosin 18 and its role in skeletal muscle: H. Lee Sweeney, P.I.      Relevance:  Myosin 18B  is  expressed  primarily  in striated  muscle  cells,  while the  closely  related  myosin 18A  is  found  in  all  cells,  including  muscle  cells.  These  myosins  are  thought  to  play  a  critical  role  in  the  formation  of  myosin  II  filaments  and  loss  of  myosin  18B  leads  to  myopathies  in  humans.  The  design  and  function  of  these  motor  proteins has not been elucidated and must be in order to understand how they function in muscle formation.

PI_NAMEs: SWEENEY, H LEE (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Address;ATP Hydrolysis;ATP phosphohydrolase;Binding;Biochemical;Biological;Biological Assay;Cell Culture Techniques;Cell Physiology;cell type;Cells;congenital myopathy;Data;design;Development;dimer;Elements;experimental study;Filament;Generations;Genes;Goals;Human;Hydrolysis;insight;Investigation;Kinetics;Length;Light;Maintenance;Mass Spectrum Analysis;Modeling;Molecular Conformation;Motility;Motor;Motor Activity;Muscle;Muscle Cells;Muscle Fibers;Mutagenesis;Mutation;Myocardium;Myopathy;Myosin ATPase;Myosin Type II;non-muscle myosin;novel;Nucleotides;Phosphorylation;Phosphorylation Site;Play;Preparation;Process;Protein Isoforms;Proteins;Publishing;recruit;Regulation;Resolution;RNA Splicing;Roentgen Rays;Role;Sarcomeres;Scaffolding Protein;Skeletal Muscle;Striated Muscles;Structure;Surface;Tissues;Transcript;Vertebrates

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: One of the big questions in understanding the brain is why individuals are differentially resilient to stress and injury. Understanding the fundamental principles and cellular mechanisms that promote resilience in individuals and the population will provide a set of concepts that will inform understanding of the loss of resilience to stress and environmental insults seen in mental illnesses.

PI_NAMEs: MARDER, EVE E (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TITLE: Differential Resilience in Models of Neurons and Circuits with Similar Outputs

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: JACOBUS, JOANNA ;TAPERT, SUSAN F (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 5/21 ABCD-USA Consortium: Research Project Site at UC San Diego


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

PHR: Project Narrative A better understanding of the barriers and facilitators for colorectal cancer screening among medically underserved African Americans will assist in monitoring more effective outreach efforts and impacting colorectal cancer disparities in groups suffering the greatest burden of the disease, thereby improving public health. The proposed study will monitor colorectal cancer screening among a cohort of African American patients in community health centers and leverage community-engaged research to study colorectal cancer screening adherence among African Americans with a goal to increase stool-based screening rates.

PI_NAMEs: LUQUE, JOHN S. (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;Affect;African American;African American population;Age;Baseline Surveys;behavioral clinical trial;burden of illness;cancer health disparity;Cellular Phone;Cessation of life;cohort;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Communities;community based participatory research;community engaged research;Community Health;community intervention;community partnership;community setting;community-level factor;cost;Counseling;County;COVID-19;COVID-19 pandemic;Decision Making;Disparity;disparity reduction;Drops;Early Diagnosis;Early identification;Education;Educational Intervention;efficacy testing;Eligibility Determination;Enrollment;Ethnic Population;Evaluation;evidence base;experience;Face;Feces;Florida;follow-up;Goals;graduate student;group intervention;Health;Health Insurance;Home;implementation determinants;improved;Incidence;Individual;Informed Consent;innovation;Insurance Coverage;Interruption;Intervention;intervention effect;Measures;medically underserved;Methods;Monitor;mortality;multi-component intervention;Neighborhood Health Center;Outcome;Outcome Study;outreach;Participant;patient oriented;patient population;Patient Schedules;Patients;Persons;Preventive;Preventive screening;Primary Care;primary outcome;programs;Public Health;racial minority population;racial population;Recommendation;recruit;Research;Risk;routine screening;screening;screening guidelines;screening program;Secure;Self Efficacy;Site;sociodemographic factors;Surveys;Testing;Text;Time;treatment as usual;Uninsured;United States Preventative Services Task Force;Universities;Update;Voice

PROJECT_TITLE: Monitoring Community Efforts to Increase Colorectal Cancer Screening in African Americans


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Gliomas account for 80% of all malignant brain and central nervous system tumors, and are responsible for an estimated 200,000 deaths worldwide and ~15,000 deaths in the United States annually. Standard of care for glioma has not changed in over 15 years. This application proposes the analysis of precise mechanisms that drive gliomagenesis using novel genetically engineered mouse models and to discover functional targets of IDH mutations, potentially assisting in the development of new therapies to combat this deadly cancer.

PI_NAMEs: XIAO, YI  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adult Glioma;Affect;alpha ketoglutarate;ATAC-seq;Brain;Brain Neoplasms;cancer initiation;Cell Differentiation process;cell fate specification;Cell Separation;Cell Size;cell transformation;Cells;Central Nervous System Neoplasms;Cessation of life;Chromatin;chromatin remodeling;Chromatin Structure;Clinical;combat;Companions;Data;Data Set;Development;Disease;DNA;DNA Methylation;Engineering;Enzymes;Epigenetic Process;epigenome;Evolution;gain of function mutation;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Anticipation;Genetic Transcription;Genetically Engineered Mouse;Glioma;Gliomagenesis;Goals;Heterogeneity;histone demethylase;histone methylation;Human;In Vitro;in vivo;Induced Mutation;insight;Isocitrate Dehydrogenase;Knowledge;Laboratories;leukemia;Link;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Metabolic;metabolome;Modeling;Molecular;Molecular Analysis;Mus;mutant;Mutation;mutational status;neural;Neuroglia;Neurons;new therapeutic target;Newly Diagnosed;novel;novel therapeutics;Oncogenes;Oncogenic;Organoids;Pattern;Population;Process;Resistance;Sampling;selective expression;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Specimen;standard of care;stem;stem cells;stem-like cell;System;Testing;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;tumor initiation;tumorigenesis;United States;Work

PROJECT_TITLE: Defining mechanisms of metabolic-epigenetic crosstalk that drive glioma initiation


ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Lay Summary: Heart attack and stroke remain the leading causes of death for men and women worldwide. Clinical observations link the hormone aldosterone with increased risk of heart attack and stroke and the hormone estrogen with protection from heart attack and stroke. Aldosterone action is increased in obesity and aging, the two fastest growing demographics in the USA. This proposal uses innovative approaches to understand how these two hormones interact with one another within blood vessels and in the immune system to contribute to heart disease. The results will help identify new ways to prevent heart attack and stroke in sex-specific ways in the rapidly growing aging and obese populations in which heart disease risk is very high.

PI_NAMEs: JAFFE, IRIS Z (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Age;Aging;Aldosterone;antagonist;Anti-Inflammatory Agents;Aorta;Apolipoprotein E;Atherosclerosis;Automobile Driving;biobank;Biological Assay;Blood Pressure;blood pressure control;blood pressure regulation;Blood Vessels;Bromodeoxyuridine;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;Cell Line;Cell Nucleus;Cell Physiology;Cells;Clinical;cytokine;Data;demographics;Disease;E-Selectin;Elderly;Endothelial Cells;ESR1 gene;Estrogens;Female;Functional disorder;Genes;Genetic;Genetic Transcription;Genomics;heart disease risk;Heart Diseases;Heart failure;high risk;Histology;Hormones;Human;human female;ICAM1 gene;Immune;Immune system;In Vitro;in vivo;Inflammation;Inflammatory;innovation;intravital microscopy;Ischemia;Kidney;Knockout Mice;Leukocyte Rolling;Leukocytes;Ligands;Link;Macrophage;male;Mediating;Medical;men;Menopause;Mesentery;Metabolic syndrome;Methods;Mineralocorticoid Receptor;Modeling;Molecular;monocyte;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Myocardial Infarction;Nitric Oxide;non-genomic;novel;obese person;Obesity;Outcome;Persons;Phenotype;Population;Premenopause;prevent;Production;Reagent;receptor;Receptor Activation;Receptor Inhibition;recruit;Regulation;Resistant Hypertension;response;Risk;Role;Rupture;Scaffolding Protein;sex;Sex Differences;Signal Transduction;Steroid Receptors;Stroke;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thinness;Thrombosis;Tissues;tool;trafficking;transcription factor;vascular inflammation;Woman;women versus men;women's prevention

PROJECT_TITLE: The Role of Vascular MR-Regulated Genes in Vascular Function and Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative There is a persistent scarcity of physicians and diverse clinical researchers engaged in the addiction research workforce, as reflected in the low numbers of NIDA research project awardees with an MD (15% in 2020) and even fewer awardees from underrepresented racial/ethnic minority (URM) populations (less than 4%). Research training programs, such as the Diversity in Addiction Research Training (DART) program (DA020537-16; formerly the Drug Abuse Research Training program), for which this application seeks renewal, will increase the number of URM investigators by involving more URM trainees in the research training pipeline earlier in their education. Greater diversity cultivates robust learning environments, fosters creativity and innovation, and promotes culturally competent care, all of which will help reduce racial/ethnic health disparities in addiction and associated mental health conditions.

PI_NAMEs: BACK, SUDIE E (contact);BRADY, KATHLEEN T.

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: addiction;Address;African American;Area;Behavioral;biopsychosocial;career;Caring;Clinical;Clinical and Translational Science Awards;Collaborations;Communities;Complex;Creativeness;cultural competence;Data;Dedications;design;Drops;Drug abuse;Education;educational atmosphere;Educational Curriculum;Educational Status;Enrollment;Ensure;equity, diversity, and inclusion;ethnic disparity;ethnic diversity;ethnic health disparity;ethnic minority;ethnic minority population;experience;Faculty;Feedback;Fostering;graduate student;Grant;hands on research;health disparity;health inequalities;Historically Black Colleges and Universities;innovation;Institution;International;Leadership;Manuscripts;Medical;Medical Students;member;Mental Health;Mental Health Associations;Mentors;Mentorship;minority investigator;minority trainee;National Institute of Drug Abuse;novel;opioid use disorder;Outcome;outreach;peer coaching;Physicians;Productivity;Program Evaluation;programs;Psychiatry;Public Health;Published Comment;Race;racial disparity;Racial Equity;racial health disparity;racial minority;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Series;social culture;South Carolina;substance use;Substance Use Disorder;success;summer research;symposium;Talents;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Virginia;virtual clinical trial;Woman;women faculty;Writing

PROJECT_TITLE: Advancing Diversity in Addiction Research Training


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative This project involves the preparation and study of proteins containing non-proteinogenic amino acids, using selected modified bacterial ribosomes to enable the incorporation of amino acids not incorporated readily by wild-type ribosomes. Two of the initiatives involve the preparation and study of proteins containing specific sites of phosphorylation or glycosylation; phosphorylated proteins include Iκ-Bα and NF-κB, while the glycosylated protein to be studied is murine interferon-β. Additionally, we will prepare proteins containing nucleobase amino acids, enabling the design of proteins able to interact in a predictable, modified fashion with their normal nucleic acid targets; proteins to be studied include transcriptional regulator Rob, and Zn finger protein Zif268.

PI_NAMEs: HECHT, SIDNEY M. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Affinity;Amino Acids;analog;Binding;Biochemical;Biological;Carbohydrates;Cell-Free System;Cells;design;Dipeptides;DNA;DNA-Protein Interaction;Fingers;Genes;genetic regulatory protein;Genetic Transcription;glycosylation;In Vitro;in vivo;inorganic phosphate;Interferon-beta;Interferons;Metabolic;Modeling;Mus;nanomolar;Nucleic Acids;nucleobase;Phenotype;Phosphorylation;Phosphorylation Site;Positioning Attribute;Preparation;Process;Protein Engineering;Protein Glycosylation;Proteins;Randomized;Regulation;Relaxation;response;Ribosomes;RNA, Ribosomal, 23S;Roentgen Rays;Serine Phosphorylation Site;Sialic Acids;Site;Specificity;Structure;System;Techniques;unnatural amino acids;Viral Physiology

PROJECT_TITLE: Biological Regulation Studied In Vitro and In Cellulo with Modified Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Aging;Hematology;Kidney Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related risk factor for inflammation and fibrosis, which are important contributors to chronic kidney disease (CKD) progression. The proposed investigation will examine associations of CHIP with kidney disease progression in large cohorts of individuals with kidney disease and in well-established animal models of kidney disease.

PI_NAMEs: HARRIS, RAYMOND C.;KESTENBAUM, BRYAN R;ROBINSON-COHEN, CASSIANNE  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adoptive Transfer;Adult;Affect;Age;age related;Animal Model;Aortic Valve Stenosis;APOL1 gene;atherogenesis;Atherosclerosis;Biological;Cardiovascular Diseases;Cells;Cessation of life;Chronic;Chronic Disease;Chronic Kidney Failure;cohort;coronary fibrosis;Data;Dependence;Diabetic Nephropathy;Dialysis procedure;Disease;Disease Pathway;Disease Progression;DNMT3a;DNMT3a mutation;Epidemiology;Epithelial Cells;experience;Experimental Animal Model;Fibroblasts;Fibrosis;functional decline;Future;Genes;Genetic;genetic risk factor;Germ Lines;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;high risk;human old age (65+);Individual;Infiltration;Inflammasome;Inflammation;Inflammatory Infiltrate;Injury to Kidney;Interleukin-1;interstitial;Intervention;Investigation;JAK2 gene;Kidney;Kidney Diseases;Lesion;Leukocytes;Link;Macrophage;Malignant - descriptor;Malignant Neoplasms;Modeling;Molecular Biology;monocyte;mouse model;multidisciplinary;Mus;Mutation;Myocardial Infarction;novel;older adult;Pathologic Processes;Persons;Population;premature;Prevalence;programs;Renal function;Renal Hypertension;resilience;Risk;Risk Factors;Role;Somatic Mutation;Stroke;systemic inflammatory response;Testing;Tissues;TP53 gene;Trans-Omics for Precision Medicine;Transplantation;Tubular formation;UMOD gene;Work

PROJECT_TITLE: Impact of Clonal Hematopoiesis on the Progression of Kidney Disease


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Self-healing dental materials have the capability of autonomically repairing damage that may occur when the restoration is subjected to, for example, excessive masticatory forces. This study proposes the synthesis of tougher healing agents, which will be able to bring this technology closer to translation to real-life uses. These modifications will prevent resin composite weakening by the addition of surface-functionalized microcapsules and turn self-healing dental materials into a feasible strategy by the introduction of coaxial electrohydrodynamic atomization, as advanced method for capsules synthesis.

PI_NAMEs: PIOVEZAN FUGOLIN, ANA PAULA  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TITLE: Novel Strategies for Self-Healing Dental Materials

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: ATHENS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Despite the risks conferred by SES-related stress, most low-income, rural children will not develop drug use problems—a phenomenon known as resilience. However, little is known regarding the influence of contextual protective factors in the indirect link between childhood adversity and drug use vulnerability among rural children. Thus, we propose to investigate the protective effects of rural context on neural risk processes associated with drug use vulnerability versus resilience among rural children (ages 7-10 years) to better inform the design and implementation of substance use prevention programs.

PI_NAMEs: OSHRI, ASSAF  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Adolescent;Affect;Age;Attenuated;Behavior;Behavioral;Behavioral Research;Buffers;Child;Child Development;childhood adversity;cognitive control;Cohort Studies;Communities;Compensation;Data;Data Reporting;deprivation;design;Development;Dimensions;drug abuse prevention;drug development;drug misuse;Drug Modelings;Drug usage;drug use vulnerability;early life adversity;Emotional;Emotions;environmental stressor;Etiology;Exhibits;experience;Exposure to;Family;family influence;functional MRI scan;Geographic Information Systems;Individual Differences;Investigation;life course persistent;Link;Low income;Mediating;Mediator;Modeling;MRI Scans;Nature;Neighborhoods;neural;Neurocognitive;neuroimaging;Neurosciences;Parents;Pathway interactions;Patient Self-Report;Pattern;peer;Population;Prevention program;primary caregiver;Process;prospective;Prospective, cohort study;protective effect;protective factors;Puberty;recruit;Research;Research Support;resilience;response;Rest;Rewards;Risk;Risk Factors;Rural;Rural Community;rural poverty;Schools;Short-Term Memory;social;Specific qualifier value;Specificity;Stress;study characteristics;substance use prevention;System;teacher;Testing;urban poverty;Youth

PROJECT_TITLE: Early Adversity and Drug Use Vulnerability Among Low Income Rural Children: Testing a Neuro-ecological Model of Resilience

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]