ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Nurses often use stigmatizing and racially-biased language in clinical documentation, which results in poor quality of care for minority patients. This project aims to design and pilot-test a technology-driven system, ENGAGE, that will help to identify and reduce the use of stigmatizing language among home healthcare nurses. Achieving this goal will reduce racial biases and improve the quality of care for patients treated in home healthcare settings.

PI_NAMEs: SITTIG, SCOTT M;TAYLOR, JACQUELYN Y;TOPAZ, MAXIM  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Affect;Algorithms;Area;Asian;Attitude;authority;behavior change;black patient;Black race;Care given by nurses;Caring;Categories;Censuses;Characteristics;Clinical;clinical care;clinical decision support;Clinical Trials;Collaborations;Computational algorithm;Data;design;Documentation;Electronic Health Record;ethnic minority;ethnic minority population;Ethnic Origin;Exhibits;experimental study;Exposure to;Geographic Locations;Geography;Goals;Health;health care service;health care settings;Health Care Visit;health disparity;Health Personnel;Healthcare;high risk;Hispanic;Home;Home Care Services;Hospitalization;Hospitals;Human;implicit bias;improved;Intervention;Interview;Language;Length;Linguistics;Louisiana;Medical;Methods;Midwestern United States;minority patient;Natural Language Processing;New York;nicotine patch;Nurses;Nursing Services;Ontology;Outcome;Outpatients;Pain;Patient Care;Patient Compliance;patient population;Patient-Focused Outcomes;Patients;phrases;Physicians;pilot test;Preparation;Prevalence;Quality of Care;Race;racial bias;racial minority;Review Literature;Sampling;Self Care;Series;Social Class;sociodemographics;Statistical Data Interpretation;Stereotyping;Stigmatization;System;Technology;Training;United States;Visit;Visiting Nurse;Work

PROJECT_TITLE: Identifying and reducing stigmatizing language in home healthcare: the ENGAGE study


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: FAMILY MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE One third of patients discharged from the hospital develop hospital-associated disability (HAD), defined as the new inability to complete ≥ 1 activities of daily living on discharge from the hospital. While it is well documented across a variety of settings that Black patients and those with social vulnerability have worse functional outcomes (i.e. mobility loss, functional decline) and physical therapy utilization, it is unknown whether these differences exist in Black patients hospitalized for acute medical illness. Given that inpatient physical therapy is important for the treatment and prevention of HAD, this career development award aims to elucidate differences, by race and social vulnerability, in hospital-associated disability and referral and usage of acute and post-acute physical therapy in patients hospitalized for acute medical illness.

PI_NAMEs: MARTINEZ, MAYLYN  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academic Medical Centers;Activities of Daily Living;Acute;acute care;Address;Admission activity;Affect;Age;age stratification;Area;black patient;Black race;black women;care systems;career;career development;Caring;Cessation of life;Chicago;Clinical Data;clinical data warehouse;Communities;comorbidity;Complex;culturally appropriate intervention;Data;Decision Making;deconditioning;Dementia;deprivation;design;Development;Development Plans;disability;disability risk;Disadvantaged;Disparity;Documentation;experience;Face;functional decline;Functional impairment;functional improvement;functional outcomes;Funding;Future;Goals;Health Care Costs;health care disparity;Health care facility;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitals;human old age (65+);Hylobates Genus;Impairment;implementation science;improved;indexing;Individual;Inpatients;Institutionalization;Intervention;K-Series Research Career Programs;Knowledge;Lead;Length of Stay;Lifelong disability;Lived experience;Logistic Regressions;Measures;Medical;Medical Care Team;Medical center;member;Mentors;Mentorship;Modeling;National Institute on Minority Health and Health Disparities;Outcome;Patient Discharge;patient population;Patients;Peripheral arterial disease;phenomenological models;Physical Function;Physical Rehabilitation;Physical therapy;Population Heterogeneity;predictive tools;prevent;Prevention;Protocols documentation;Qualitative Methods;Race;racial determinant;racial difference;racial disparity;racism;readmission risk;Recommendation;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Resources;Risk;risk prediction;Role;Sampling;sex;Site;skills;social determinants;social vulnerability;socioeconomics;Statistical Models;Testing;Training;Trauma;Underserved Population;United States National Institutes of Health;Variant;White Women;Work

PROJECT_TITLE: Racial Differences in Hospital-Associated Disability and Acute and Post-Acute Care Physical Therapy Utilization


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Public Health Relevance Using a rigorous longitudinal design with participants from a large HIV clinic in Los Angeles area, this study will develop and test an integrated intervention program that uses the advanced ingestible sensor system to trigger intervention sessions in real-time when missed doses are detected to address challenges in social and behavioral determinants of health associated with poor adherence and viral suppression in a timely way. This enhanced intervention has great potential to improve adherence to antiretroviral medications in HIV treatment for those who have significant difficulties in adherence and are at high risk for virologic failure and transmission of HIV to sexual partners and others.

PI_NAMEs: DAAR, ERIC S;LIU, HONGHU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adherence;Adult;age group;aged;Annual Reports;Anti-Retroviral Agents;antiretroviral therapy;Area;arm;Behavioral;Caring;Case Manager;Clinic;co-infection;cohort;Complex;County;Detection;digital health;Disparity;Dose;efficacy evaluation;empowerment;Epidemic;Evaluation;Event;Evolution;Failure;FDA approved;Feedback;follow-up;food insecurity;Frequencies;Geography;Goals;health determinants;high risk;high risk sexual behavior;HIV;HIV diagnosis;HIV Infections;Homelessness;Hot Spot;housing instability;improved;Incentives;Inequity;Information Technology;innovation;Intervention;intervention program;Life;longitudinal design;Los Angeles;Measurement;Measures;methamphetamine use;Monitor;multidisciplinary;new technology;Outcome;Participant;Pathway interactions;patient population;Patient Self-Report;Patients;Pattern;Persons;Pharmaceutical Preparations;pill;Plasma;post intervention;Poverty;primary endpoint;Proteus;public health relevance;Publications;Randomized;real time monitoring;Recording of previous events;recruit;Reporting;Research;response;Risk;RNA;Running;safety net;secondary endpoint;sensor;sensor technology;Sex Behavior;sexual HIV transmission;Sexual Partners;Sexually Transmitted Diseases;social;social stigma;Social Workers;Specific qualifier value;Substance Use Disorder;synergism;Syphilis;System;Team Nursing;Testing;Text Messaging;therapy development;Time;transmission process;treatment as usual;Update;usual care arm;Validation;Viral;Viral Load result;Woman;young man

PROJECT_TITLE: An integrated intervention using a pill ingestible sensor system to trigger actions on multifaceted social and behavioral determinants of health among PLWH


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Despite growing policy activity to offer health care coverage to low-income, uninsured undocumented immigrants, there is only limited evidence on this population’s health care utilization in the context of expanded access to care to support these policies and guide their implementation. This R21 project will examine a long- standing local program that provides health coverage for ~130,000 undocumented patients annually to investigate how expanded access to care affects undocumented patients’ outcomes and health care utilization. We will use patient medical records, enrollment records, and Medicaid claims to provide evidence on the impact of expanded access to care on patient outcomes and understand ED, outpatient, inpatient, and prescription utilization over time.

PI_NAMEs: RO, ANNIE EUN YOUNG (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adult;Advocate;Affect;Age;California;Caring;Characteristics;Chronic;Chronic Disease;Clinic;Clinical;Communities;cost;County;COVID-19 pandemic;Data;Data Sources;Development;Disease Management;Effectiveness;Emergency Care;Emergency department visit;Enrollment;Ethnic Origin;Event;evidence base;Exclusion;Federally Qualified Health Center;Frequencies;Funding;Gender;Goals;Health;health care availability;health care disparity;health care service utilization;health disparity populations;health plan;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospital Records;Hospitalization;Immigrant;Immigration;Improve Access;improved;Individual;inpatient service;Inpatients;insight;Intervention;Language;Leadership;Los Angeles;Low income;Low Income Population;Medicaid;Medicaid eligibility;Medical;medical specialties;National Institute on Minority Health and Health Disparities;older patient;Outcome;Outpatients;participant enrollment;Patient Care;patient health information;patient home care;Patient-Focused Outcomes;Patients;Pattern;Policies;Policy Maker;Population;population health;Pregnant Women;Prenatal care;Preventive care;Primary Care;programs;Public Hospitals;Race;Records;Research;Research Personnel;Sampling;Source;Strategic Planning;Subgroup;Testing;Time;Uninsured;Visit;Work

PROJECT_TITLE: Access to medical care and health care utilization among low-income immigrants

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative The proposed study will to evaluate the role of structural racism and discrimination in cancer control behaviors as well as identify psychosocial moderators of the relationship between structural racism and discrimination and cancer control behaviors, in probability samples of African Americans from four focal states. Study findings have the potential to inform practice, research, and policy to improve the health of African Americans, with a particular focus on activities to foster cancer prevention and avoid cancer risk behaviors.

PI_NAMEs: GHOSH, DEBARCHANA ;KNOTT, CHERYL L (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adult;African American;African American population;Alabama;Area;Behavior;Behavior Control;Buffers;Cancer Burden;Cancer Control;cancer health disparity;cancer prevention;cancer risk;Censuses;Characteristics;Classification;Communities;community engaged approach;community intervention;community involvement;Connecticut;County;Data;Databases;design;Diet;Dimensions;Discrimination;Education;environmental justice;Ethnic Origin;Exposure to;Feedback;Fostering;Future;Gender;Geographic Locations;Goals;Health;Health behavior;Health Disparities Research;Health Promotion;Home;Housing;Hybrids;Imprisonment;improved;Incidence;indexing;Individual;Institutional Racism;Intervention;Jail;Life Style;Lived experience;Location;Malignant Neoplasms;Maps;Maryland;Measures;Medical;Methods;Missouri;Modeling;mortality;multidisciplinary;multilevel analysis;Nature;Neighborhoods;outcome disparities;Participant;Pattern;Persons;PhenX Toolkit;Physical activity;Policies;policy implication;Policy Maker;Population;Poverty;Probability Samples;psychosocial;psychosocial resources;Race;racial identity;Racial Segregation;racism;Recommendation;Religion;Reproducibility;Research;Research Personnel;residence;residential segregation;resilience;Resources;Risk Behaviors;Role;rural area;Sampling;screening;Screening for cancer;secondary analysis;segregation;Smoking;social;social health determinants;Social support;Socioeconomic Status;structural determinants;structural health determinants;Structural Racism;Surveys;System;Telephone;Testing;tool;urban area;Violence;Visualization;web app;Work

PROJECT_TITLE: Multidimensional structural racism and moderating role of psychosocial resources on cancer-control behaviors in African Americans

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Traumatic injuries caused more than 200,000 deaths and the loss of 2 Million potential life years in the US in 2019, disproportionately harming health disparities populations. There is an increasing body of evidence suggesting systematic inequities in access to trauma care are a substantial driver of injury disparities. We aim to identify system-level causes of injury disparities and develop recommendations for interventions to mitigate injury disparities.

PI_NAMEs: JARMAN, MOLLY PRICE (contact)

PROJECT_TERMS: access disparities;Address;Algorithms;American College of Surgeons;Biological Models;black patient;Black race;care systems;Caring;Case Study;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Clinical;Consensus;cost;Data;Disparity;disparity elimination;Disparity population;disparity reduction;Dissemination and Implementation;effectiveness evaluation;Emergency medical service;Engineering;Equity;Ethnic Population;evidence base;Future;Geographic Locations;Geography;Goals;health disparity populations;Hispanic;Hospitals;Human Resources;Improve Access;improved outcome;Incidence;Infrastructure;Injury;injury burden;Intervention;Interview;Knowledge;Life;Link;Literature;Low income;Low Income Population;marginalization;Maryland;Measures;Mediating;Mediation;Medical;Medicine;Methods;Modeling;mortality;mortality risk;Nurses;Operative Surgical Procedures;Outcome;outcome disparities;Pathway interactions;Patients;Persons;Physician Executives;Policy Maker;Population;prevent;Process;programs;Protocols documentation;racial population;Recommendation;Reduce health disparities;Reporting;Resource Allocation;Resources;response;Risk Reduction;Rural;rural dwellers;Sampling;secondary outcome;Series;severe injury;Signal Transduction;Source;standard care;Structure;Surveys;System;Testing;Time;Transportation;Trauma;trauma care;trauma centers;Trauma patient;Trauma Research;Traumatic injury;trend;Triage;United States Agency for Healthcare Research and Quality;United States National Academy of Sciences;Work

PROJECT_TITLE: Mitigating Injury Disparities with Evidence Based Trauma Systems Planning


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: PEDIATRICS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency department visits, and hospitalizations. Project ASTHMA (Aligning with Schools To Help Manage Asthma) tests the effectiveness of school-based health centers as a delivery model to improve health outcomes by providing children with guideline-based asthma assessments and preventive medication management, directly observed therapy of their preventive medication to support adherence, and self-management support. If successful, this multicomponent intervention will represent a cost effective and sustainable model to reduce asthma morbidity in historically marginalized communities, and has the potential to impact communities throughout the United States where over 2,500 school- based health centers operate.

PI_NAMEs: HOLMES, LUCY  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Absenteeism;Adherence;Adrenal Cortex Hormones;Age;Asthma;asthma exacerbation;asthma inhaler;asthma model;Back;Black race;caregiver quality of life;Caregivers;Caring;Child;Child Health;Childhood Asthma;Chronic;Chronic Care;Chronic Disease;Clinical;Cluster randomized trial;Communities;Comprehensive Health Care;cost;cost effective;cost effectiveness;Cost Savings;Country;County;Decision Making;design;Directly Observed Therapy;Disease Management;Dose;Economics;Education;effectiveness evaluation;effectiveness testing;Emergency department visit;Employment;Enrollment;experience;Family;functional improvement;functional outcomes;Goals;Guidelines;Health;health assessment;health care availability;Health Care Costs;health care delivery;health inequalities;Health Services Accessibility;Healthcare;Hispanic;Home;Hospitalization;hospitalization rates;improved;Inequity;Inhalation;Interruption;Intervention;marginalized community;Medical;Medical Care Costs;Medication Management;Methodology;Methods;Modeling;Morbidity - disease rate;multi-component intervention;novel;Observational Study;Outcome;Outcome Measure;Pharmaceutical Preparations;Physicians' Offices;Pilot Projects;Policy Maker;poor communities;Poverty;Prevalence;prevent;Prevention;Preventive;primary care provider;primary outcome;Productivity;programs;prospective;Provider;Public Health;Public Sector;Randomized;randomized trial;Recommendation;Research;Resource Allocation;Resources;safety net;school based health center;School Nursing;Schools;Self Management;Service delivery model;social determinants;social health determinants;socioeconomics;Spirometry;Students;suburb;success;Symptoms;Testing;Time;Training;Translating;Transportation;treatment as usual;underserved community;United States;Vulnerable Populations;Work

PROJECT_TITLE: Project ASTHMA - Aligning with Schools to Help Manage Asthma and Decrease Health Inequities

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Malaria remains a global scourge of with almost 50% of humans living in endemic areas. Several promising vaccine candidates work well in malaria naïve volunteers, but show diminished potency when evaluated in the malaria experienced populations. This application seeks to determine what features of malaria cause diminished vaccine responses and how these responses can be improved to enhance vaccine potency.

PI_NAMEs: HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Africa South of the Sahara;Animal Model;Anti-malarials;Antibody-mediated protection;Antigen Presentation;Antigens;Area;Attenuated;Beds;Blood;Bone Marrow;CD8-Positive T-Lymphocytes;Child;Clinical Trials;combat;Cryopreservation;Data;Development;Dissection;Drug resistance;Erythrocytes;Ethics;experience;Experimental Designs;Exposure to;Functional disorder;Genetic Polymorphism;global health;Goals;Hemoglobin;hemozoin;Human;humanized mouse;Immune response;Immune system;Immune System Diseases;Immunity;Immunization;improved;Incidence;Individual;infected vector rodent;Infection;Injections;Insecticides;insight;Knowledge;Liver;Logistics;Malaria;malaria infection;Malaria Vaccines;Mediating;Memory;mouse model;Mus;Parasite resistance;Parasites;pathogen;Pharmacotherapy;Plasmodium;Plasmodium falciparum;Population;prevent;Radiation;radiation response;Radiobiology;Regimen;response;Rodent;Route;Scourge;Severities;Spleen;Sporozoites;T cell response;T memory cell;T-Lymphocyte;Tissues;Vaccination;vaccine candidate;vaccine response;Vaccines;Virulent;volunteer;Work

PROJECT_TITLE: Mechanisms of compromised CD8 T cell responses to vaccination in malaria experienced hosts

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Project Narrative: This project will advance a novel MHC class II construct, DRhQ, that has the potential to treat people with progressive multiple sclerosis (MS) as well as other CNS conditions that are high priority research areas for VA Veterans including stroke, traumatic brain injury and methamphetamine addiction. The aims of this project are to evaluate multi-compartmental pharmacokinetics, validate relevant biomarkers, including infusion induced cytokine release, inhibition of phosphorylated extracellular-related kinase (pERK1/2) and related cytokines and inhibition of IL-2 secretion induced by activated T-cells, as well as potential neutralizing activity of anti-drug antibodies against DRhQ. These studies will provide critical preclinical data for an IND submission for FDA approval of DRhQ for Phase 1 and 2 clinical trials.

PI_NAMEs: VANDENBARK, ARTHUR A. (contact)

PROJECT_TERMS: Acute;Address;Affect;Antibodies;antibody detection;Area;B-Lymphocytes;Binding;Biological;Biological Assay;Biological Markers;Blocking Antibodies;Blood;Caring;CCL2 gene;CCL4 gene;Cells;Central Nervous System;chemokine;Chronic;Clinical;Clinical Trials;Clinical Trials Design;CNS Demyelinating Autoimmune Diseases;commercialization;Coupled;cytokine;Data;Dendritic Cells;design;Development;Diagnosis;disabling disease;Dose;Drug Kinetics;Endothelial Cells;Excretory function;experience;Experimental Autoimmune Encephalomyelitis;extracellular;Extracellular Domain;FDA approved;Feedback;first-in-human;Funding Agency;Generations;Goals;Grant;Half-Life;Haplotypes;HLA-DR2 Antigen;Homologous Gene;Human;human study;Immunoglobulin G;Immunoglobulin M;immunoregulation;in vivo;Individual;Inflammatory;Infusion procedures;Injections;Interleukin-10;Interleukin-2;Interleukin-6;invention;Investigational Drugs;Investigational New Drug Application;Label;Laboratories;Legal patent;Link;Macrophage;Macrophage Activation;manufacture;meetings;Methamphetamine dependence;MHC Class II Genes;Middle Cerebral Artery Occlusion;migration;Migration Inhibitory Factor;monocyte;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Neurologic;Neurologic Deficit;neuroprotection;neutralizing antibody;Neutralizing antibody assay;novel;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Plasma;potential biomarker;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Primary Progressive Multiple Sclerosis;Process;programs;receptor;Relapse;Relapsing-Remitting Multiple Sclerosis;research clinical testing;Research Priority;Resources;Risk Factors;Rodent Model;Role;Safety;Secondary Progressive Multiple Sclerosis;Secondary to;Serum;Severities;Signal Transduction;Small Business Technology Transfer Research;Stroke;stroke model;success;T-Cell Activation;T-Lymphocyte;Therapeutic;Therapeutic Effect;Time;Tissues;TNF gene;Toxicology;Translating;translational study;Traumatic Brain Injury;Treatment Efficacy;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans;young adult

PROJECT_TITLE: Preclinical Translational Studies with DRHQ


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed study will transform mental health care by addressing both supply and demand side barriers through provision of accessible and evidence-based care delivered by racially and culturally congruent providers; enabling care to be delivered regardless of a formal diagnosis; and empowering majority-minority, mostly first- generation college-attending students to acquire the skills to respond and become change agents for their communities in Texas, a region with some of the greatest unmet behavioral health needs in the country. Importantly, through specialized training, tangible Community Health Worker certification, and focused mentorship with a team of faculty from historically underrepresented race/ethnic groups, the academic and career trajectory of students at risk for prolonged undergraduate enrollment or, worse, dropout may be altered. This transformative project has important implications for further dissemination and widespread understanding of the organizational and contextual factors which act as barriers to implementation of evidence-based interventions and can serve as a blueprint for guiding Minority Serving Institutions across the country to address the mental health needs of racial and ethnic minority groups in low resourced communities who have experience disparities in access and outcomes.

PI_NAMEs: SANCHEZ, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: access disparities;addiction;Address;Anxiety;Attention;Behavioral;behavioral health;brief intervention;career;Caring;Certification;college;Communities;community advisory board;community collaboration;Community Health;Community Health Aides;Competence;Consultations;contextual factors;cost;Counseling;Country;demographics;design;Diagnosis;Diagnostic;digital solutions;Disabled Persons;Disparity;disparity reduction;Diverse Workforce;Dropout;Early Intervention;Educational Curriculum;empowerment;Enrollment;Ensure;Equity;ethnic diversity;ethnic minority population;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Faculty;Frequencies;Funding;Generations;Goals;Health;health disparity;health equity;Health Personnel;Health Services Accessibility;Health system;Healthcare Systems;higher education;implementation barriers;implementation framework;implementation science;Improve Access;indicated prevention;inequitable distribution;Infrastructure;innovation;insight;Institution;Intervention;intervention cost;intervention delivery;Measures;medical schools;medical specialties;Mental Depression;Mental Health;Mental Health Services;mental state;Mentorship;Methodology;Minority;Minority Groups;Minority-Serving Institution;Modeling;National Institute of Mental Health;Not Hispanic or Latino;Outcome;Patients;peer;people of color;Population;Population Group;Poverty;Preventive care;preventive intervention;Process;Production;programs;Provider;psychosocial;quality assurance;Quality of Care;Race;racial diversity;racial minority population;racial population;recruit;Reporting;Research;Resource-limited setting;Resources;response;retention rate;Risk;scaffold;scale up;Side;skill acquisition;skills;social determinants;Social Work;Specialist;Structure;Students;Supervision;Texas;Time;Training;Training Activity;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Train and EMPOWER A Community Health workforce to achieve equity and reduce disparities in mental health (TEACH)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Defects in the mitotic entry control system can lead to genomic instability, a hallmark of cancer, and cell shape changes are associated with multiple stages of cancer progression including metastasis. We will use the model organism fission yeast to define of the upstream signals that govern mitotic entry and polarized growth in eukaryotes. These findings will be important to understand the cellular mechanisms that prevent untimely and inappropriate cell divisions, which contribute to human diseases such as cancer.

PI_NAMEs: MOSELEY, JAMES B (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Area;Biochemical;Biological Models;biological systems;CDC2 gene;Cell Cycle;Cell division;cell growth;Cell Nucleus;Cell Polarity;Cell Shape;Cell Size;Cells;Cyclin-Dependent Kinases;Cyclins;Cytoplasmic Granules;Defect;design;Eukaryota;Eukaryotic Cell;Fission Yeast;Fluorescence Microscopy;Funding;Future;Genetic;Genetic Screening;Genomic Instability;Goals;Growth;human disease;interdisciplinary approach;Knowledge;live cell microscopy;Malignant Neoplasms;Mammals;mathematical model;Mitosis;Mitotic;model organism;Molecular;Monitor;mutant;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;Organism;particle;Pathway interactions;Pattern;phosphoproteomics;Positioning Attribute;prevent;Process;Protein Kinase;Proteins;reconstitution;Regulation of Cell Size;Reproducibility;Research;RNA;Rod;Role;Shapes;Signal Transduction;simulation;SNAP receptor;Surface;System;therapeutic target;tumor progression;Work;Yeasts

PROJECT_TITLE: Mechanisms controlling cell size and shape

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Informed, shared-decision making is critical to ensure Veteran-centered, values-concordant care. This is especially important with regards to ICDs, permanent devices that require an invasive procedure for implant with intent to monitor and treat life-threatening arrhythmias. ICDs present a complicated balance of patient benefit (ie. treatment of dangerous heart rhythms), procedural risk, long-term maintenance and impact on psychological health (ie. PTSD, anxiety and depression from ICD shocks). Research shows providers overemphasize ICD benefits while patients overestimate benefit, poorly comprehend risks, psychological effects, and complications. The central hypothesis of this proposal is that the current ICD decision-making process is heterogeneous and lacks sufficient Veteran perspective. Aligned with the VA Strategic Plan, this work will shift this paradigm to a Veteran-centered, shared-decision making process. Broadly, this project can set the standard for Veteran-centered care with application to other invasive cardiovascular procedures.

PI_NAMEs: SANDHU, AMNEET  (contact)

PROJECT_TERMS: Address;Anxiety;Arrhythmia;auricular appendage;Benefits and Risks;blood pressure control;cardiac device;cardiac implant;Cardiovascular system;career;Caring;Chronic Disease;Clinical;clinical care;clinical practice;Communication;Communication Methods;comorbidity;Complement;Complex;Conflict (Psychology);Dangerousness;Data;Decision Aid;Decision Making;design;Detection;Development;Devices;diabetic;Dissemination and Implementation;Documentation;effectiveness/implementation trial;Eligibility Determination;Ensure;Equilibrium;evidence base;expectation;feasibility testing;Feedback;follow-up;Funding;Future;Goals;Health;Health Services;Heart failure;Heart Rate;heart rhythm;Implant;Implantable Defibrillators;implantation;Implantation procedure;implementation tool;impression;improved;In Situ;Individual;Infection;Infrastructure;innovation;Intervention;Interview;Knowledge;Lead;Left;Life;Maintenance;Measures;Mental Depression;Mental Health;Methodology;Methods;Modeling;Monitor;mortality;Operative Surgical Procedures;Outcome;Output;Pamphlets;Paper;Paternalism;Patient Compliance;patient-clinician communication;Patients;personalized decision;Post-Traumatic Stress Disorders;preference;prevent;procedure cost;Procedures;Process;professional atmosphere;Provider;psychologic;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regrets;Research;Research Personnel;Risk;satisfaction;shared decision making;Shock;Site;skills;Special Population;standard of care;Strategic Planning;Structure;sudden cardiac death;support tools;System;Testing;Texas;theories;tool;tool development;Travel;uptake;usability;Variant;Veterans;web site;Work

PROJECT_TITLE: Development of a Veteran-Centered Approach to ICD Decision-making in the VA

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Elder abuse (EA), the abuse, exploitation or neglect of an older adult by another person in a trust relationship (e.g., family caregiver), is experienced by 10% of older adults annually in the US. Older adults who experience EA are more likely to have depression, injury, additional hospitalizations, and early mortality. With the US population aging and >10 million US Veterans over age 60, addressing EA and its consequences is both a national and VA public health priority. Unfortunately, an estimated 95% of EA cases go undetected, limiting opportunities to intervene and improve health outcomes. Therefore, enhancing detection is the necessary first step to improving care for older adults experiencing EA. This project aims to improve EA detection in the VA, the country’s largest integrated healthcare system, by assessing how EA screening can be improved and by leveraging medical record data so healthcare teams can proactively identify older Veterans at high risk. These findings will help the VA meet its goal of providing high quality care to older Veterans and their caregivers.

PI_NAMEs: MAKAROUN, LENA  (contact)

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;Aging;aging population;candidate marker;care delivery;career;Caregivers;caregiving;Caring;Characteristics;Clinical;Clinical Pathways;Code;Cognitive;Complement;Complex;Country;Data;Data Element;Dedications;Dementia;Detection;Development;Diagnostic;Early identification;effectiveness testing;Elder Abuse;Elder abuse prevention;emotional abuse;Evaluation;evidence base;experience;Family Caregiver;financial exploitation;Future;future implementation;Geriatric Assessment;Geriatrics;Goals;Harm Reduction;Health;Health Care Visit;Health equity research;health service use;Health Services;Health system;Healthcare;Healthcare Systems;High Prevalence;high risk;high risk population;Hospitalization;Hybrids;implementation barriers;implementation science;implementation strategy;improved;informant;Informatics;Injury;innovation;Integrated Health Care Systems;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;intervention program;Interview;Knowledge;Leadership;Link;Long-Term Care for Elderly;Managed Care;Manuals;Medical Care Team;Medical center;Medical Records;Mental Depression;Mental Health;Methodology;Methods;Mission;Morbidity - disease rate;mortality;Natural Language Processing;neglect;novel;novel strategies;older adult;Older Population;Outcome;Patients;Personal Satisfaction;Persons;physical abuse;Population;Positioning Attribute;Predictive Analytics;Prevalence;Process;programs;Provider;public health priorities;Qualitative Methods;Quality of Care;Quantitative Evaluations;Questionnaires;recruit;Reference Standards;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;risk mitigation;screening;Screening procedure;Services;Sexual abuse;Site;skills;social;Social Problems;Social Work;Standardization;Surveys;Testing;tool;Training;Trust;United States;Veterans;whole health;Work

PROJECT_TITLE: Identifying Risk and Improving Care for Elder Abuse among Veterans


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: To meet the growing demand for long-term care services while enabling veterans to receive care in their setting of choice, VA has tried, with limited success, to rebalance its long-term care expenditures away from institutional care and towards home and community-based services (HCBS). This CDA explores the role played by key patient, system, and family level factors in VA’s rebalancing efforts. The research aims apply recent innovations in natural language processing, risk adjustment, geospatial statistics, and causal modeling, and lead to an independent research agenda that will help VA improve its HCBS patient targeting tools, identify potential home health contractors, and develop appropriate supports for its informal caregivers. The proposed research addresses a key HSR&D Cross-Cutting Priority Area, Long-term Care and Caregiving, and will help VA operations make informed decisions about how to maximize the effectiveness and reach of scarce long-term care dollars.

PI_NAMEs: JACOBS, JOSEPHINE  (contact)

PROJECT_TERMS: acute care;Address;Adult;Affect;Ambulatory Care;Area;Budgets;care costs;care systems;career development;Caregiver support;Caregivers;caregiving;Caring;causal model;Characteristics;Collaborations;community based service;community setting;Computerized Medical Record;connected care;Contract Services;Contractor;Contracts;cost;Data Sources;Databases;Discipline of Nursing;Econometric Models;Effectiveness;Equilibrium;Evaluation;evidence base;Expenditure;Family;feasibility testing;functional status;Funding;Geriatrics;Goals;Growth;Health;Health Benefit;health care quality;health care service utilization;Health Personnel;Health Services;Health system;Healthcare;Healthcare Market;high risk;Home;Home Care Services;Home Health Agency;human old age (65+);improved;Individual;informal care;informal caregiver;informal support;innovation;Institution;Institutionalization;International;Investments;Knowledge;Life;Literature;Long-Term Care;Marketing;Measures;Medicaid;meetings;Mentors;Mentorship;Methods;Modeling;Natural Language Processing;Nursing Homes;operation;Outcome;Patients;Pattern;Performance;Play;Policy Maker;predictive modeling;Preparation;Primary Care;programs;prospective;Research;Research Personnel;Risk;Risk Adjustment;Role;Self Care;Services;skills;statistics;Structure;structured data;success;System;Testing;Text;Time;tool;Training;Veterans

PROJECT_TITLE: Helping VA optimize its long-term care services


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: I am applying for 5 years of support for mentored training and research. The proposed research projects address a key gap in care quality for smokers with chronic obstructive pulmonary disease (COPD): improving the reach of tobacco cessation treatments. Proactive tobacco treatment programs effectively engage smokers in care yet are rarely implemented. Smokers with COPD appear to respond particularly well to a proactive offer of tobacco treatment, suggesting they are a high-impact group to target. I propose to develop and test a proactive tobacco treatment program for smokers with COPD to be delivered electronically. We expect that an electronic proactive tobacco treatment intervention will increase utilization of cessation services with low associated cost. I will obtain mentored training in qualitative and mixed methods research, design and testing of behavioral tobacco interventions with a focus on mobile health, and cost analysis. This award supports my long-term career goal of improving Veterans’ health through increasing access to effective tobacco cessation.

PI_NAMEs: MELZER, ANNE CATHERINE (contact)

PROJECT_TERMS: Address;Adoption;Affect;Area;Award;behavior test;Behavioral;budget impact;care coordination;career;Caring;Cause of Death;Chronic Disease;Chronic Obstructive Pulmonary Disease;clinical care;Communication Methods;comparative effectiveness trial;comparison intervention;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effective;Counseling;Data;design;Development;Doctor of Philosophy;Effectiveness;Electronic Mail;Electronics;Enrollment;Evaluation;evidence base;Evidence based treatment;experience;Feedback;Future;future implementation;Goals;Health;health information technology;Health Promotion;Health Services;Health Services Research;Health Technology;Healthcare Systems;high risk population;implementation efforts;implementation facilitators;implementation science;improved;individualized medicine;Intention;interest;Intervention;Interview;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Leadership;low socioeconomic status;lung health;Medical;Mentors;Methods;mHealth;Modeling;Nicotine Dependence;Outcome Assessment;outreach;outreach program;patient engagement;Patient Participation;Patient Recruitments;Patients;Pharmaceutical Preparations;program costs;programs;prospective;Pulmonology;Qualifying;Qualitative Research;Quality of Care;Randomized;recruit;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Respiratory Disease;Respiratory Signs and Symptoms;response;Secure;Services;Site;skills;Smoke;Smoker;Smoking;smoking cessation;sound;success;Surveys;Symptom Burden;Target Populations;Technology;Telephone;Testing;therapy development;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;Tobacco Use Disorder;Training;training project;treatment as usual;treatment program;Veterans;Veterans Health Administration;Visit;Workload

PROJECT_TITLE: Electronic Proactive Outreach for Smokers with COPD: Engaging patients to quit


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Machine Learning and Artificial Intelligence;Maternal Health;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: RAYDIANT OXIMETRY, INC.

PHR: Project Narrative Raydiant Oximetry, Inc. has developed and patented a novel optical sensing technology to noninvasively monitor fetal oxygenation. This technology will enhance surveillance of fetal status during labor and delivery by improving the ability of clinicians to detect fetal hypoxia. This Phase II SBIR effort will advance the technology towards commercialization by the collection and incorporation of human data training sets for refinement of the computational algorithms for calculation of fetal oxygen saturation with subsequent validation of this algorithm to support an IDE application with the FDA.

PI_NAMEs: RAY, NEIL PADHARIA (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 3-Dimensional;Abdomen;Advanced Development;adverse outcome;Agreement;algorithm development;Algorithms;Award;Calibration;Cardiotocography;Cesarean section;Clinical;Clinical Research;Collection;commercialization;Communities;Computational algorithm;Computer Models;Computer Simulation;computerized data processing;Confidence Intervals;Data;Data Set;deprivation;design;Detection;Development;Devices;Electronics;Emergency Situation;ewe model;fetal;fetal blood;fetal diagnosis;Fetal Distress;Fetal Heart Rate;Fetal Monitoring;Fetal Reduction;Fetus;fetus at risk;fetus hypoxia;first-in-human;Future;Goals;Health Care Costs;heart rate monitor;Hospitals;Human;human data;human subject;Hypoxemia;Hypoxia;improved;in utero;in vivo;Institutional Review Boards;interest;intrapartum;Label;Legal patent;Machine Learning;machine learning model;Marketing;Measurement;Medical;Metabolic acidosis;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;Neonatal;neonatal hypoxic-ischemic brain injury;neonatal outcome;network architecture;Newborn Infant;non-invasive monitor;novel;Optics;Outcome;Output;Oxygen;Oxygen saturation measurement;Performance;Phase;Physiologic Monitoring;Physiologic pulse;pre-clinical;preclinical study;Pregnant sheep;Pregnant Women;Protocols documentation;Pulse Oximetry;Reporting;Research;response;Risk;Sensitivity and Specificity;sensor technology;Sheep;Signal Transduction;Small Business Innovation Research Grant;Specificity;System;Techniques;Technology;Tissues;Training;training data;transfer learning;Update;Uterine Contraction;Validation;virtual

PROJECT_TITLE: Advancing Fetal Assessment during Labor with Transabdominal Fetal Oximetry


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative  Personality traits, executive function skills, and economic preferences that emerge in childhood impact children’s health and life outcomes, particularly through physical and psychological wellbeing, educational achievement, and workforce decisions. This study will collect and analyze data on traits, skills, and preferences that emerge in childhood and examine how these attributes evolve and co-evolve during adolescence. We will use survey and administrative data from schools as well as self-reported health measures to examine the predictive validity of the elicited measures in order to inform best practices for school evaluations and assist teachers in designing student-tailored curricula, which may also inform public health.

PI_NAMEs: CARLSON, STEPHANIE M.;DOHMEN, THOMAS ;HECKMAN, JAMES J (contact);KYLLONEN, PATRICK C

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Absenteeism;Achievement;Adolescence;Adolescent;Adolescent Development;Adult;Affect;Age;Altruism;American;Australia;Behavior;behavioral economics;Characteristics;Chicago;Child;Child Development;Child Health;Childhood;China;Chinese;cohort;Complement;Country;Data;Data Collection;design;Development;Dimensions;Economics;Education;Educational Curriculum;Educational Status;elementary school;Emotional;Employment;Environment;Environmental Risk Factor;Ethnic Origin;Evaluation;Evolution;executive function;Factor Analysis;Family;Family Characteristics;Fostering;frontier;Gender;German population;Germany;Gills;Grant;Health;Household;Human;Human Development;Incentives;Income;Inequality;Institution;Intervention;Investigation;Joints;Language;Lead;Life;Life Cycle Stages;Literature;Measurement;Measures;Mental Health;Methodology;Methods;Minnesota;Modeling;Monitor;Occupations;Outcome;outcome prediction;parental influence;parental role;Parents;Patient Self-Report;Performance;Personal Satisfaction;Personality Traits;physical conditioning;preadolescence;Predictive Factor;preference;Problem behavior;Protocols documentation;psychologic;Psychologist;Psychology;Public Health;Questionnaires;Race;Research;Research Project Grants;response;Risk;Sampling;Scheme;Schools;Secondary Schools;Site;skills;social;social disparities;Social Environment;Socioeconomic Status;socioeconomics;standard measure;Standardization;Structure;Students;Subgroup;success;Surveys;System;teacher;Testing;testing services;Tilia;Time;trait;Universities;Wages;Well in self;Work

PROJECT_TITLE: Aligning Measurement of Psychological Traits and Economic Preferences

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Secretory proteins responsible for essential cellular functions such as communication and defense are synthesized in the endoplasmic reticulum (ER) and then exported out of ER, a process accompanied by accidental export of ER-resident proteins, which poses a stress on cellular survival. These ER-resident proteins are retrieved back by the COPI machinery, which is hijacked by coronaviruses to traffic their spike protein for viral progeny assembly, thus presenting a pathway to advance our understanding of fundamental secretory protein trafficking and to identify targets for therapeutic intervention in COPI-associated diseases, COVID-19, and in future coronavirus outbreaks. The investigations proposed in this grant will provide mechanistic details underlying the hijacking of COPI by the spike and the atomic details of fine-tuning in this interaction, thus advancing the biological principles of secretory homeostasis.

PI_NAMEs: HASAN, SYED SAIF  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 2019-nCoV;Accidents;Acetaminophen;Affect;Amino Acids;Analgesics;Applications Grants;Autoimmunity;Back;Binding;Binding Proteins;Binding Sites;Biochemical;Biogenesis;Biological;Biological Models;biophysical tools;Biophysics;C-terminal;Cell membrane;Cell Physiology;Cellular Assay;Chimera organism;Coated vesicle;Coatomer Protein;Communication;Complex;Coronavirus;Coronavirus spike protein;coronavirus vaccine;COVID-19;COVID-19 pandemic;Data;Destinations;Development;developmental disease;Devices;Disease;Disease Outbreaks;Dissection;Drug Metabolic Detoxication;Electrostatics;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Environment;Epidemic;Equilibrium;experimental study;Functional disorder;Future;gene product;Glucuronosyltransferase;Goals;Golgi Apparatus;Grant;Health;Heart;Homeostasis;Hormones;Human;Immune system;Immunologics;improved;in silico;innovation;insight;Interferometry;Investigation;Knowledge;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Membrane Proteins;Middle East Respiratory Syndrome Coronavirus;mimicry;Modeling;Modification;Molecular Conformation;Morphine;mutant;Mutation;Names;novel;novel coronavirus;Nutrient;Organelles;Pathway interactions;Polysaccharides;Post-Translational Protein Processing;posters;Process;Protein Biosynthesis;protein function;protein transport;Proteins;Publications;Publishing;Reagent;receptor;recruit;Regulation;Retrieval;Role;SARS-CoV-2 spike protein;secretory protein;Site;Stress;Tail;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;trafficking;uptake;Vesicle;Viral;Viral Proteins;X-Ray Crystallography;Xenobiotics

PROJECT_TITLE: Biophysical, Structural, and Cellular Dissection of COPI-Dependent Retrograde Trafficking Using a Coronavirus Toolkit

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The Appalachian Tobacco Regulatory Research Team (AppalTRuST) will investigate the impact of Federal Drug Administration Center for Tobacco Products (FDA CTP) regulatory policies in rural communities, a vulnerable and understudied population, through collaboration, education and pioneering regulatory scientific research. Our three projects and four cores are designed to bridge the knowledge gap in rural tobacco use behaviors, guided by a definition of rurality that accounts for heterogeneity. Our approach is designed to inform the use of a health equity lens in shaping current, proposed, and future FDA regulatory actions to reduce rural tobacco use disparities.

PI_NAMEs: HIMELHOCH, SETH S;KOFFARNUS, MIKHAIL NIKOLAAS;ROSE, SHYANIKA W (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adult;Affect;Age;Appalachian Region;Area;Behavior;Biometry;Calibration;Cancer Center;career;cohort;Collaborations;college;Communities;community engaged research;Community Outreach;cost efficient;County;Data;data integration;Data Science;data warehouse;design;Discipline of Nursing;Disparity;Ecological momentary assessment;Education;Ensure;Environment;Epidemiology;Evaluation;experience;Future;Goals;health economics;health equity;Heterogeneity;Individual;Informatics;Infrastructure;innovation;Kentucky;Knowledge;Link;low nicotine content cigarette;Marketing;Measures;Medicine;Menthol;Mentors;Methodology;multidisciplinary;Nicotine;novel;Outcome;Participant;patient engagement;Patient Recruitments;Pattern;peri-urban;Pharmaceutical Preparations;Policies;polytobacco use;Population;Probability Samples;programs;prospective;Public Health;public policy on tobacco;Randomized;recruit;Regulation;Research;Research Institute;Research Personnel;Resources;Rural;rural area;Rural Community;rurality;Sampling;Science;Shapes;Subgroup;synergism;Time;Tobacco;tobacco advertising;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tobacco user;Traumeel S;Universities;Variant;young adult

PROJECT_TITLE: Appalachian Tobacco Regulatory Science Team (AppalTRuST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R(50)R]


PI_NAMEs: RAYENS, MARY KAY (contact)

PROJECT_TERMS: Address;Adult;Appalachian Region;Area;Attitude;Behavior;Catchment Area;Censuses;Characteristics;Cigar;Cigarette;cigarette smoking;cigarillos;Cities;cohort;Cohort Studies;County;Cues;Data;demographics;density;design;Disincentive;Disparity;Electronic cigarette;electronic cigarette use;Enrollment;Equity;Funding;Future;Geographic Locations;Goals;Health;health belief;health equity;heated tobacco products;Heterogeneity;hookah;Income;Individual;Inequity;informant;innovation;insight;Interview;Kentucky;Knowledge;Longitudinal cohort;Longitudinal Studies;Longitudinal trends;low nicotine content cigarette;Marketing;Masks;Measures;Menthol;Methods;Modeling;multidisciplinary;Nicotine;novel;Participant;Pattern;Perception;peri-urban;Pharmaceutical Preparations;Policies;policy implication;population based;Positioning Attribute;Predisposition;Prevalence;Productivity;Publications;Reaction;Recording of previous events;recruit;Regulation;Research;residence;Resources;Rest;Risk;Rural;rural America;Rural Appalachia;rural area;Rural Community;Rural Population;rurality;Shapes;smoke-free policy;Smokeless;Smokeless Tobacco;Surveys;Taxes;Testing;Time;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;United States National Institutes of Health;Update;urban area;Urbanization;Variant;Visit

PROJECT_TITLE: AppalTRuST Project 1: Population based Cohort study of tobacco use prevalence in Appalachian KY

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE: OVERALL Significant progress has been made in reducing cigarette smoking in the United States, but notable disparities persist in menthol cigarette smoking and in the use of non-cigarette tobacco products, including little cigars and e-cigarettes. UNC TCORS will conduct four integrated Research Projects that will inform FDA efforts to communicate more effectively with the public about tobacco products (i.e., little cigars and cigarillos, menthol cigarettes, and e-cigarettes) and identify the public health impact and unintended consequences of an FDA flavored cigar ban. This new evidence will identify specific actions that FDA can implement to reduce existing disparities in tobacco product use.

PI_NAMEs: RIBISL, KURT M. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adult;aged;Asian;Attitude;Behavior;Belief;Bisexual;Black race;career;Cigar;Cigarette;cigarette smoking;cigarillos;Communication;design;Disadvantaged;Disparity;Electronic cigarette;electronic cigarette use;Epidemic;Funding;Gays;Goals;health disparity;High Prevalence;Hispanic;Income;Individual;knowledge base;Lesbian;Lesbian Gay Bisexual;Low income;low socioeconomic status;Marketing;Menthol;Mentorship;models and simulation;mortality disparity;multidisciplinary;non-cigarette tobacco product;novel;Pattern;Policies;Population;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Predisposition;Prevalence;Prevention;programs;Public Health;Reduce health disparities;reduce tobacco use;Regulation;Research;Research Personnel;Research Project Grants;Safety;Sampling;Science;Seasons;Smoke;Smoker;smoking cessation;success;Testing;Tobacco;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;United States;United States National Institutes of Health;vaping;young adult;Youth

PROJECT_TITLE: Advancing Tobacco Regulatory Science to Reduce Health Disparities


PI_NAMEs: GOLDSTEIN, ADAM O (contact)

PROJECT_TERMS: addiction;Adult;Age;Area;arm;Attention;Attitude;Behavior;behavior change;Belief;Black Populations;Black race;Cellular Phone;Cigar;Cigarette;cigarette smoking;cigarillos;Communication;Consumption;Crowding;design;Development;digital;digital media;Disparity;disparity reduction;effectiveness evaluation;Environment;experimental study;Exposure to;Focus Groups;Goals;High Prevalence;insight;Instagram;Investigation;Learning;Literature;malignant mouth neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of larynx;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Participant;Play;Population;primary outcome;Process;Published Comment;Race;Randomized, Controlled Trials;Reduce health disparities;Regulation;Research;Role;Science;secondary outcome;Smoke;social media;Surveys;Technology;Testing;theories;Time;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;Tobacco Use Cessation;visual tracking;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Advancing Communication Science to Reduce Disparities in Young Adult Cigar Use


PI_NAMEs: ROSE, SHYANIKA W (contact)

PROJECT_TERMS: Adult;Advertising;Affect;Age;age group;Appalachian Region;Area;Attitude;Authorization documentation;Baseline Surveys;Behavior;Cancer Burden;cancer health disparity;Catchment Area;Censuses;Cigar;Cigarette;Cities;Communities;community advisory board;County;Data;density;digital;Disparity;Ecological momentary assessment;economic disparity;Electronic cigarette;electronic liquid;Environment;Epidemic;Equity;evidence base;experience;Exposure to;federal policy;follow-up;Frequencies;Future;geographic disparity;Geography;Goals;health disparity;Individual;Industry;Influentials;innovation;Kentucky;Link;low nicotine content cigarette;Marketing;Menthol;Modified Risk Tobacco Product;Nicotine;novel;Outcome;Participant;Patient Self-Report;Pattern;Perception;peri-urban;Persuasive Communication;Policies;Population;Population Density;Predisposition;Prevalence;Price;public policy on tobacco;reduce tobacco use;Regulation;Reporting;Research;response;Risk;Rural;Rural Appalachia;rural area;Rural Community;rural counties;rural disparities;Rural Population;rurality;Sampling;Smokeless Tobacco;Smoking;smoking cessation;social media;socioeconomic disadvantage;Source;theories;Time;Time trend;Tobacco;tobacco advertising;tobacco exposure;tobacco flavor;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tobacco user;United States Food and Drug Administration;urban area;web site;Work;young adult

PROJECT_TITLE: AppalTRuST Project 2: Exposure to tobacco marketing for novel tobacco products and associations with future tobacco use in Appalachian young adults: tobacco regulatory science implications


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SCOTTSDALE

ORG_NAME: SEQUITUR HEALTH CORP.

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The objective of this R44 research is to test a new device to measure metabolite levels at home in patients at risk for metabolic crises. In the long term, home use of this device will enable physicians to better control patients to avoid metabolic crises and dramatically reduce the negative consequences of metabolic crises. Daily home monitoring of metabolic status will improve the lifelong outcomes of these vulnerable patients by enabling timely use of known and effective treatments for reducing metabolite levels to prevent or treat metabolic crises.

PI_NAMEs: THOMAS, MARYLAURA LIND (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Acute;Age;Ammonia;Behavior;Blinded;Blood;Caregivers;Cessation of life;Chronic;Clinical;Clinical Trials;clinically relevant;Cognition;cohort;commercialization;Consensus;Data;Data Analyses;Databases;Development;Devices;Diet;disability;Disease;Drops;effective therapy;Emergency department visit;Ensure;Event;experience;Fasting;fatty acid oxidation;Foundations;Frequencies;Funding;Future;Genetic;Goals;Health;health equity;Health Sciences;Hereditary Disease;high risk;Home;Home environment;Hyperammonemia;Impaired cognition;improved;Individual;innovation;innovative technologies;Institutional Review Boards;Intellectual functioning disability;interest;Intervention;Knowledge;Laboratories;Manuscripts;Marketing;Measurement;Measures;Medical;medical attention;Medical emergency;Medical Records;meetings;member;Metabolic;Metabolic Diseases;Metabolism;meter;Monitor;Morbidity - disease rate;mortality;Neurologic;Neurologic Dysfunctions;Neurologic Symptoms;Oregon;Outcome;Participant;participant enrollment;Patient Care;patient population;Patient Recruitments;Patients;Performance;Persons;Pharmaceutical Preparations;Physicians;Physiology;Plasma;point of care;Population;prevent;Prevention;Preventive measure;real time monitoring;Recommendation;recruit;Research;response;Risk;Safety;Science;Signal Transduction;Small Business Innovation Research Grant;Surveys;Symptoms;Target Populations;Testing;Thinking;Time;time use;United States Food and Drug Administration;United States National Institutes of Health;Universities;Urea cycle disorders;Work

PROJECT_TITLE: Home Monitoring of Metabolic Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative: Overall The overall objective of the Penn State TCORS is to provide a science base for reducing the harm from tobacco products. We are pursuing the Food and Drug Administration’s Comprehensive Plan for Tobacco and Nicotine Regulation by determining the toxicity of aerosols, smoke, and oral exposures of tobacco products that may be used as substitutions for cigarettes. This includes identifying the specific characteristics of non- cigarette products that can be regulated to reduce harm.

PI_NAMEs: FOULDS, JONATHAN ;MUSCAT, JOSHUA E (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: addiction;Address;Aerosols;Affect;Analytical Chemistry;Area;authority;base;Basic Science;Biological;Biological Markers;Biometry;career development;Career Mobility;Characteristics;Chemicals;Cigar;Cigarette;Clinical Research;Collaborations;combustible tobacco;Communication;Communities;Data;data management;design;Development;Devices;Education;Electronic cigarette;electronic cigarette user;electronic liquid;Emerging Tobacco Products;epidemiologic data;experience;exposed human population;Flavoring;Free Radicals;Harm Reduction;Health;Inhalation;Knowledge;Laboratory Animal Models;Laboratory Study;Length;Marketing;Measurement;Measures;Mentors;Methodology;Methods;Mission;multidisciplinary;Nicotine;Nitrates;non-cigarette tobacco product;novel;novel marker;Oral;Oxidants;Oxidative Stress;Persons;Pilot Projects;Placebos;Production;programs;Randomized Controlled Clinical Trials;Regulation;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Project Grants;Research Support;Resource Development;Resources;Risk;Role;Sampling;Science;Scientist;Senior Scientist;Series;Smoke;Smoker;Source;stem;student training;System;Temperature;Testing;Time;Tobacco;tobacco exposure;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco smoke;tobacco toxicant;Tobacco use;Toxic effect;Translational Research;translational study;United States Food and Drug Administration;ventilation;Work

PROJECT_TITLE: Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction


PI_NAMEs: HALL, MARISSA  (contact)

PROJECT_TERMS: Address;Age;Area;Behavior;behavior measurement;behavioral outcome;Black Populations;Black race;Cigarette;Cigarette Smoker;cigarette smoking;Cities;Communication;consumer behavior;Decision Making;Development;Disparity;Equation;experimental study;Feedback;Focus Groups;General Population;Goals;Industry;innovation;Intervention;intervention effect;Interview;Legal;Lesbian Gay Bisexual;Litigation;Location;Maps;Measurement;Measures;Mediation;Mediator;Menthol;Methods;Modeling;North Carolina;Participant;Persons;Phase;Policies;Population;primary outcome;Process;psychologic;Randomized;Reaction;recruit;Reduce health disparities;Regulation;Research;Research Design;response;Sales;Sampling;Science;secondary outcome;Self Efficacy;Shapes;simulation;Smoke;Smoker;smoking cessation;Stigmatization;Surveys;Techniques;Testing;three-arm trial;Time;tobacco advertising;tobacco flavor;Tobacco Industry;tobacco regulatory science;tool

PROJECT_TITLE: Amplifying the menthol cigarette ban’s impact in priority populations with a quit smoking campaign


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Unrelieved pain is highly prevalent and devastating for Veterans in Community Living Centers (CLCs). This Career Development Award capitalizes on the imminent removal of pain as one of the CLC quality measures to develop new, risk-adjusted measures that more accurately characterize pain management. These measures will identify top-performing CLCs. By diving deeply into their unique organizational structures and processes for achieving high quality pain management, we can learn how to intervene. My background in gerontology, quantitative methods, and implementation science partially prepares me for this work. The proposed CDA simultaneously fills considerable gaps in my training—in risk adjustment, qualitative research, cutting-edge analytic methods, and intervention study design—and provides VA with rigorous, actionable research on which to ground future quality improvement efforts.

PI_NAMEs: PIMENTEL, CAMILLA BENEDICTO (contact)

PROJECT_TERMS: acceptability and feasibility;Adoption;analytical method;Area;authority;career;Caring;Characteristics;Chronic Disease;Cladribine;Clinical;Clinical effectiveness;clinical implementation;clinical practice;Collaborations;community living;comparative;contextual factors;Custom;dashboard;Data;Data Set;data warehouse;design;Development;deviant;disabled;Disease Management;Diving;effectiveness testing;Elderly;evidence base;evidence based guidelines;Evidence based intervention;Excision;Feedback;formative assessment;Future;Geriatrics;Gerontology;Goals;Growth;Health;health care delivery;health care quality;Health Services Research;Healthcare;Home;Homogeneously Staining Region;hybrid type 2 design;Hybrids;implementation intervention;implementation science;improved;innovation;Intervention;Intervention Studies;Investments;K-Series Research Career Programs;Knowledge;Lead;Learning;Long-Term Care;Measurement;Measures;Medicare/Medicaid;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Nursing Homes;Opioid;organizational structure;Pain;Pain Clinics;Pain management;Pain Measurement;pain model;pain outcome;Pain quality;Patients;Pattern;Performance;Policies;population health;Practice Management;Preparation;Process;programs;Provider;Qualitative Evaluations;Qualitative Research;Quality of life;Randomized;Reaction;Reporting;Research;Research Design;Risk Adjustment;severe mental illness;skills;social;Structure;Substance Use Disorder;Surveys;symptom management;System;Testing;Training;Validity and Reliability;Variant;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Applying Positive Deviance Methods to Harness Optimal Practices for Effective Pain Management in Community Living Centers


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Research on clinical safety of prehospital emergency care, particularly for older adult patients, has lagged significantly behind other clinical domains despite being an essential component of the continuum of health care. In response to the urgent need for enhancing and supporting safety, and quality, and equity within pre- hospital emergency care, we propose to establish the Resilient_EMS Learning Lab. The Resilient_EMS Learning Lab is tailored to use systems and human factors engineering approaches to generate results salient to developing interventions to support `real time' cognitive work of emergency medical technicians/ paramedics, using a prospective systems-based approach in a variety of EMS pre-hospital care environments (rural, suburban, urban).

PI_NAMEs: GURSES, AYSE PINAR (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Resilient EMS PSLL: Using a Systems Engineering Approach to Enhance EMS Cognitive Work and Safety for Older Adults During Prehospital Care.

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


PI_NAMEs: KOFFARNUS, MIKHAIL NIKOLAAS (contact)

PROJECT_TERMS: abuse liability;Appalachian Region;authority;Behavior;behavioral economics;Biometry;Catchment Area;Cigarette;Cities;combustible cigarette;Communities;Community Outreach;Complex;Consumption;Data;design;Economics;Elasticity;Environment;falls;Goals;Grant;Informatics;low nicotine content cigarette;Manufacturer;Measures;Menthol;Methods;Modeling;Nicotine;nicotine user;Participant;patient engagement;Pattern;peri-urban;Policies;Price;prospective;Public Health;Randomized;Recommendation;recruit;Regulation;Research;Rural;Rural Appalachia;rural area;Rural Community;rural underserved;rurality;Sampling;Taxation;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;United States Food and Drug Administration;urban area;Variant

PROJECT_TITLE: AppalTRuST Project 3: Impact of proposed tobacco product rules in Appalachia on consumption and product switching with the Experimental Tobacco Marketplace


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: This VA Career Development Award will ensure Dr. Woodward’s expertise in VA healthcare implementation research through formal training and applications of her knowledge through small research studies. Her specific training areas are on how to ensure effective treatments are used in routine clinical practice in VA healthcare, especially for Veterans who are sometimes overlooked in healthcare (e.g., racial minority, lower income). She will apply this knowledge to research studies that involve working with Veterans and their families and caregivers and using their feedback to best design VA healthcare, specific to suicide prevention in rural VA clinics.

PI_NAMEs: WOODWARD, EVA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Ambulatory Care Facilities;Area;Award;behavioral health;career;Caregivers;Clinic;Clinical;clinical practice;Communities;community based participatory research;Competence;Consumer Participation;Data;design;Development;direct application;Disparity;effective intervention;effective therapy;effectiveness/implementation hybrid;Ensure;Evaluation;evidence base;experience;Family;Feedback;Feeling suicidal;follow-up;Future;General Population;Goals;Health behavior and outcomes;health care disparity;health care quality;health care service;health disparity;health equity;Healthcare;Healthcare Systems;hospital care;Human Resources;Impact evaluation;implementation facilitation;implementation intervention;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;implementation study;improved;improved outcome;Infrastructure;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Low income;Manuals;meetings;member;Mental Depression;Methodology;Methods;Monitor;novel;Outcome;Patients;Policies;Population;prevent;Prevention;Process;process evaluation;programs;Provider;Psychologist;racial minority;Reduce health disparities;reducing suicide;Reporting;Research;Research Methodology;Research Personnel;research study;Risk;Rural;Rural Population;Safety;safety assessment;Scientist;Severities;Site;skill acquisition;Standardization;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Techniques;Testing;Training;United States Department of Veterans Affairs;Update;uptake;Variant;Veterans;Veterans Health Administration;Voice;Vulnerable Populations;Work

PROJECT_TITLE: Veteran Engagement Implementation Strategies to Prevent Rural Veteran Suicide


PI_NAMEs: MILLS, SARAH  (contact)

PROJECT_TERMS: Address;Adult;Affect;Behavior;Black race;Characteristics;Cigar;Cigarette;cigarette smoke;Cigarette Smoker;cigarillos;Collaborations;combustible tobacco;Communication;contextual factors;Country;Data;Demographic Impact;design;Disease;Effectiveness;Electronic cigarette;ethnic minority;Ethnic Origin;Face;Health;Health Benefit;health disparity;improved;Individual;Inequity;Legal;Literature;Low income;Maintenance;Marketing;Markov Chains;Menthol;Modeling;models and simulation;Monitor;mortality;mortality disparity;North Carolina;Pattern;Persons;Pharyngeal structure;Phase;Policies;polytobacco use;Population;Population Assessment of Tobacco and Health;Population Group;population health;Positioning Attribute;Poverty;Prevalence;Probability;Public Health;Race;racial minority;Reduce health disparities;Regulation;Research;Research Priority;Sales;Science;Smoke;Smoking;Study models;Subgroup;System;systematic review;Taste Perception;Time;Tobacco;tobacco control;tobacco flavor;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tobacco user;tool;United States;United States Food and Drug Administration;Universities;Update;Youth

PROJECT_TITLE: Modeling the public health impact of a flavored cigar ban


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE - OVERALL The Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) will examine how ingredients in tobacco products, including nicotine and chemicals that produce cooling and sweetness, contribute to product initiation, continued use, and addiction. We also will investigate if these ingredients may help people switch from smoking cigarettes to using non-combustible products like e-cigarettes and oral nicotine pouches. Career development activities and collaborations will develop the next generation of tobacco regulatory scientists.

PI_NAMEs: KRISHNAN-SARIN, SUCHITRA  (contact);O'MALLEY, STEPHANIE S

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: addiction;addiction liability;Address;Adolescence;Adolescent;Adult;Animal Model;authority;base;Behavior;behavior test;Behavioral;Biological;Biological Markers;Biological Testing;career;career development;Chemicals;Chemistry;Cigarette;Collaborations;combustible tobacco;Communication;Communities;data management;Data Set;design;Development;Discrimination;Electronic cigarette;electronic cigarette use;Ensure;Equilibrium;experience;Exposure to;Faculty;Family Smoking Prevention and Tobacco Control Act;Foundations;Funding;Generations;Goals;Grant;Harm Reduction;Health;Heart;Human;Inhalation;innovation;insight;interdisciplinary approach;Intravenous;Knowledge;Laboratories;Legal;Marketing;mature animal;Measurement;Measures;Menthol;Mentorship;Methods;Modeling;multidisciplinary;next generation;Nicotine;Nicotine Dependence;nicotine exposure;novel;Oral;Persons;pharmacologic;Physiologic pulse;Pilot Projects;Policies;preference;Psychological reinforcement;Psychometrics;Public Health;Publications;recruit;Regulation;Research;Research Personnel;respiratory;Rewards;Role;Route;Sarin;Science;Scientist;Self Administration;Smoking;Sodium Chloride;Solvents;sound;standardize measure;Statistical Data Interpretation;Stereoisomer;Sweetening Agents;Testing;Tobacco;Tobacco Dependence;Tobacco Industry;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Toxic effect;Training;United States Food and Drug Administration;United States National Institutes of Health;Work


PI_NAMEs: HIMELHOCH, SETH S (contact)

PROJECT_TERMS: Address;Administrator;Appalachian Region;Applications Grants;Behavior;Behavioral;Biometry;career;cigarette smoking;Clinical;Collaborations;college;combustible tobacco;Communication;Communities;community advisory board;community collaboration;Community Outreach;Coordination and Collaboration;Counseling;Data Collection;data management;Decision Making;design;Education;Electronic cigarette;Ensure;Environment;Equity;Evaluation;experience;Faculty;Fostering;Funding;Goals;Grant;improved;Informatics;Infrastructure;innovation;Kentucky;Knowledge;Lead;Leadership;Learning;low nicotine content cigarette;Marketing;Medicine;meetings;Menthol;Methodology;Nicotine;Nicotine Dependence;novel;Nursing Faculty;Occupational activity of managing finances;operation;Oral;Paper;Participant;patient engagement;Pharmaceutical Preparations;Pilot Projects;Policies;polytobacco use;Process;programs;Publishing;Quality Control;Recommendation;recruit;Regulation;Reporting;Research;Research Personnel;Resources;Rural;rural area;Rural Community;rurality;Scholars Program;Science;scientific atmosphere;Series;Shapes;skills;socioeconomic disadvantage;Strategic Planning;Structure;synergism;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;United States National Institutes of Health;Universities;Variant;visiting scholar;Water;Work;Writing

PROJECT_TITLE: AppalTRuST Administrative Core


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Prevention

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE We propose to adapt, assess and support scale up of a tailored, video-based counseling package for adolescents living with HIV (ALHIV): VITAL (Video Intervention to Inspire Treatment Adherence for Life) Start for Adolescents (VS4A), an intervention on the primary composite outcome of retention and adherence (viral load <1000 copies/ml) in a multisite cluster randomized controlled trial (CRCT) in Malawi. If effective, VS4A can be an innovative, scalable tool to improve service delivery for ALHIV while also liberating HCW time and reducing health system burden in Malawi. Building on a 15-year partnership with the Malawi Ministry of Health (MOH), a track record of excellence and innovation in service to ALHIV, and a robust implementation science research portfolio, our team is poised to successfully implement the VS4A study and program and to use findings to support rapid, wide-scale dissemination and scale up.

PI_NAMEs: AHMED, SAEED  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adoption;Africa South of the Sahara;arm;behavior change;Behavioral;Caring;Cessation of life;Childhood;Clinic;Complex;cost effective;cost effectiveness;cost-effectiveness ratio;Counseling;Country;Dedications;Development;Dimensions;disability-adjusted life years;Disclosure;Drug resistance;Effectiveness;Enrollment;experience;Film;Fostering;Friends;Health;Health Personnel;Health Resources;Health system;HIV;HIV-infected adolescents;human centered design;Human immunodeficiency virus test;Hybrids;implementation science;improved;incremental cost-effectiveness;Infection;innovation;International;Intervention;Kenya;Knowledge;Life;low and middle-income countries;Malawi;mathematical model;Modeling;mortality;multidisciplinary;Outcome;Participant;Patients;Pharmaceutical Preparations;primary outcome;Procedures;programs;psychosocial;Randomized;Randomized, Controlled Trials;Research;resistance mutation;satisfaction;scale up;secondary outcome;service delivery;Services;Site;South Africa;standard of care;Standardization;Stretching;successful intervention;Supervision;Teenagers;theories;Time;tool;Training;treatment adherence;Uganda;Viral;Viral Load result;Youth

PROJECT_TITLE: VS4A: VITAL Start (Video-Intervention to Inspire Treatment Adherence for Life) for Adolescents, a video intervention to improve retention and adherence to ART among adolescents living with HIV


PI_NAMEs: NOAR, SETH MICHAEL (contact)

PROJECT_TERMS: addiction;Adolescent;Adolescent and Young Adult;Age;aged;Archives;Attitude;Behavior;Belief;Categories;cigarette smoking;Code;Communication;cost;Country;Disparity;Education;Effectiveness;Electronic cigarette;experimental study;Goals;Health;Intervention;Knowledge;Length;Lesbian Gay Bisexual;machine learning method;Media Campaign;Modeling;Music;Outcome;Participant;peer;Population;Predisposition;prevent;Prevention;primary outcome;prospective;Public Health;Random Allocation;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Regulation;Resources;Risk;Sampling;Science;secondary outcome;Series;Sex Orientation;Smoking;Smoking Behavior;Smoking Prevention;sound;Source;Surveys;Tobacco;tobacco products;tobacco regulatory science;tool;two-arm trial;United States Food and Drug Administration;uptake;vaping;Visual;Work;young adult;Youth

PROJECT_TITLE: Understanding the Impact of Vaping Prevention Ads on Adolescents and Young Adults


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Crown Point

ORG_NAME: NEURODON LLC

ORG_STATE: IN

PHR: With a growing patient population and no approved therapeutics that slow or halt disease progression, Alzheimer’s disease (AD) is a major national health burden. This Phase IIB proposal aims to conduct preclinical and IND-enabling studies on our novel lead and backup compounds that correct neuronal calcium handling and showed beneficial effects on learning and memory in an animal model of AD. Our previous Phase II research met our goal of identifying orally active development candidates, and this proposal aims to conduct required efficacy, safety, toxicology, and process research to support the IND application.

PI_NAMEs: DAHL, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;AD transgenic mice;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein Precursor;Animal Model;Apoptosis;Apoptotic;Biological Markers;biomarker driven;Brain;brain cell;Ca(2+)-Transporting ATPase;Calcium;Cardiac;Cell Death Induction;Cell model;Chemistry;Clinical;Clinical Research;clinical translation;Clinical Trials;Cognition;Cognitive deficits;Data;Development;Disease;Disease Progression;drug development;drug discovery;Drug Targeting;efficacy study;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzyme Inhibition;Evaluation;Formulation;Functional disorder;Future;Gene Mutation;Generations;Genes;Goals;Health;Homeostasis;Human;improved;In Vitro;in vivo;Induction of Apoptosis;innovation;Lead;Learning;Legal patent;Link;manufacture;MAPT gene;Measures;Memory;Memory Loss;Modality;mouse model;multidisciplinary;Mus;Nerve Degeneration;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;new chemical entity;novel;novel therapeutics;Oral;Oral Administration;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physiological;pre-clinical;preclinical development;preclinical study;Preparation;presenilin-1;prevent;Probability;Process;programs;Proteins;Public Health;Pump;Research;response;Risk;Safety;scale up;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;sobriety;solid state;specific biomarkers;success;Symptoms;Synapses;tau Proteins;Testing;theories;Therapeutic;therapeutic candidate;Toxicology;Transgenic Mice;transgenic model of alzheimer disease;Work

PROJECT_TITLE: Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


PI_NAMEs: ASHFORD, KRISTIN H. (contact)

PROJECT_TERMS: Address;Appalachian Region;Archives;Area;Behavior;behavioral economics;Biometry;career;Charge;cohort;Collaborations;Communities;Community Outreach;community partnership;Decision Making;Dedications;design;Development;Educational workshop;Ensure;Environment;experience;Faculty;Foundations;Funding Mechanisms;Goals;Grant;Growth;hands on research;Informatics;innovation;interest;Journals;Lead;Learning;Marketing;meetings;Menthol;Mentors;Methodology;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;next generation;Nicotine;patient engagement;Pilot Projects;Policies;Postdoctoral Fellow;programs;recruit;Research;Research Design;Research Methodology;Research Personnel;Resources;Rural;Rural Appalachia;rural area;Rural Community;Scholars Program;Science;Science Enrichment;Scientist;Series;skills;Stream;Talents;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;Translating;Translations;United States National Institutes of Health;visiting scholar;web site;Work;Writing

PROJECT_TITLE: AppalTRuST Career Enhancement Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: Project Narrative Worldwide and in the U.S. lung cancer is the leading cause of cancer mortality. Our proposal identifies risk factors at each step of lung cancer development to understand the mechanisms controlling and influencing its progression and to identify biomarkers that can be used clinically for early detection. We have also included diverse communities in our research program, in order to identify approaches to engage them in risk reduction strategies.

PI_NAMEs: AMOS, CHRISTOPHER I. (contact);HUNG, RAYJEAN J.;JOHANSSON, MATTIAS ALEXANDER;LIN, XIHONG

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Adopted;Adoption;Advisory Committees;Basic Science;Behavior;Behavior assessment;behavior influence;Biological Markers;biomarker identification;Cancer Burden;Cancer Control;Cancer Detection;Cancer Etiology;cancer prevention;cancer risk;Cessation of life;Clinical;clinical practice;Communities;computed tomography screening;Data Analyses;Death Rate;Development;Diagnosis;Dose;Early Diagnosis;Environmental Risk Factor;environmental tobacco smoke exposure;Funding Agency;genetic risk factor;genomic predictors;Goals;Health;high risk;implementation research;improved;Individual;insight;interest;Life Cycle Stages;low dose computed tomography;low-dose spiral CT;lung cancer screening;lung development;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Minority Groups;mortality;Names;National Institute of Drug Abuse;National Institute of Environmental Health Sciences;National Institute of General Medical Sciences;never smoker;non-smoker;novel;novel marker;novel strategies;Output;Paper;Population;Population Heterogeneity;Population Research;Population Study;Populations at Risk;Primary Prevention;Prognosis;programs;Publishing;radiological imaging;Research;Risk;Risk Assessment;Risk Factors;Risk Management;risk prediction;Risk Reduction;screening;screening guidelines;Smoking Behavior;Spiral Computed Tomography;Stage at Diagnosis;success;Suggestion;Translating;translational approach;Translations;tumor progression;uptake

PROJECT_TITLE: Integrative Analysis of Lung Cancer Etiology and Risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Although use of interpreters is the “gold standard” in hospital and clinic settings for communicating with limited English proficient (LEP) patients, in prehospital emergency care interpreters are seldom used, and it is less clear when use of professional over-the-phone interpreter (OPI) services is appropriate or how 9-1-1 dispatchers decide on connecting to OPI during 9-1-1 calls with LEP callers. We propose a multi-method study to 1) Identify call characteristics that are associated with OPI use and associated communication and care delivery outcomes during real-life 9-1-1 calls with LEP callers and 2) Identify key dispatcher attributes associated with use of and time to OPI during simulated scenarios (developed based on information collected in Aim#1) with LEP Spanish, Mandarin and Cantonese mock callers. Third, we plan to translate and disseminate the results of the study via training opportunities and policy recommendations identified by emergency medical services (EMS) and community stakeholders, using a participatory Delphi technique.

PI_NAMEs: MEISCHKE, HENDRIKA W. (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Accident and Emergency department;Adverse event;Affect;Awareness;Belief;care delivery;Caring;Characteristics;Charge;Chinese;Client satisfaction;clinical care;Clinics and Hospitals;Communication;Communication Barriers;Communities;community partners;Complex;Decision Making;Delphi Technique;Development;Disparity;distrust;Emergency Care;Emergency medical service;Emergency response;emergency settings;Emergency Situation;Emotional;Emotions;Environment;experience;first responder;Fright;Goals;Health;health equity;health equity promotion;Health Status;improved;Individual;Inequity;Instruction;Knowledge;Language;Life;Limited English Proficiency;Linguistics;Medical;Medical emergency;Methods;Nature;Outcome;patient-clinician communication;Patients;Pattern;Policies;policy recommendation;Pre-hospitalization care;Prehospital Emergency Care;Process;Recording of previous events;Reporting;Research;response;Route;Sampling;satisfaction;Services;skills;social;Spanish;stem;System;Telephone;Time;Training;training opportunity;Translating;Translations;Triage;United States;Visit;Work

PROJECT_TITLE: Improving linguistic health equity in prehospital emergency care

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


PI_NAMEs: HULL, PAMELA CARMEN (contact)

PROJECT_TERMS: Address;Adult;Age;Appalachian Region;Back;Behavior;Biometry;Calibration;Cities;cohort;Communities;community advisory board;community engaged research;Community Outreach;contextual factors;cost efficient;County;Data;Data Collection;data resource;data warehouse;design;Devices;digital;Electronic Mail;Electronics;eligible participant;Enrollment;Ensure;Equity;follow-up;Fostering;Future;Goals;Heterogeneity;Home;Individual;Informatics;innovation;insight;interest;Interview;Kentucky;Knowledge;Libraries;Longitudinal Studies;low health literacy;Marketing;Mass Media;meetings;Monitor;Outcome;outreach;Participant;participant enrollment;participant retention;patient engagement;Pattern;peri-urban;Persons;Pilot Projects;Printing;Probability Samples;recruit;Regulation;Reporting;Research;Research Project Grants;retention rate;Rural;Rural Appalachia;Rural Community;Rural Population;rurality;Sampling;Services;Shapes;social media;Statistical Methods;Surveys;System;Taxonomy;Telephone;Text;Time;tobacco regulation;tobacco regulatory science;Tobacco use;tobacco user;Training;Trust;Update;Variant;Visit;web site;Work;Writing;young adult

PROJECT_TITLE: AppalTRuST Community Outreach and Participant Engagement Core


PI_NAMEs: RIBISL, KURT M. (contact)

PROJECT_TERMS: Accountability;Address;Advocate;Behavior;career;Collaborations;Communication;Communities;Coordination and Collaboration;Disparity;Electronic cigarette;Ensure;Equity;experience;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Goals;Grant;Health equity research;Infrastructure;Lead;Leadership;meetings;multidisciplinary;operation;Pilot Projects;Policies;policy implication;Population;Press Releases;Principal Investigator;Process;programs;Public Health;public policy on tobacco;Published Comment;Records;recruit;Reduce health disparities;Regulation;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;response;Science;Scientist;success;symposium;synergism;Tobacco;tobacco flavor;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Translating;United States National Institutes of Health;Vision;web site;webinar;Work;working group

PROJECT_TITLE: Administrative Core