ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Myeloproliferative neoplasm (MPN) is a hematologic malignancy driven by a somatically acquired mutation most commonly in JAK2 (JAK2V617F), which currently lacks effective therapies for early stage patients, thus necessitating the development of novel treatment modalities. Preliminary clinical and experimental work has identified inflammation as an important factor that influences the relative growth rate of mutant cells, and preliminary collaborative mathematical modeling work indicates that this can potentially have a variety of consequences for the evolution of mutant cells at homeostasis. Novel computational methods, in combination with experimentation, are used to identify mechanisms of JAK2V617F mutant selection, to predict the evolutionary trajectories of JAK2V617F mutant cells under various inflammatory conditions, and to identify and test therapeutic targets to steer cellular evolution away from disease.

PI_NAMEs: FLEISCHMAN, ANGELA GOFFREDO (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Acute;Acute Myelocytic Leukemia;alternative treatment;Aspirin;Benign;Biological Assay;Biological Models;Blood coagulation;Cell Lineage;cell type;Cells;Chronic;Clinical;Clinical Trials;Collaborations;Complex;Computing Methodologies;Cues;Data;design;Development;Disease;Disease Progression;Dose;drug discovery;Early treatment;effective therapy;Evolution;experimental study;Future;Goals;Growth;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Homeostasis;improved outcome;in silico;in vivo;Inflammation;Inflammatory;inhibitor;Intervention;JAK2 gene;Kinetics;Laboratories;mathematical model;Mathematics;Measures;Mediating;Modality;Modeling;mouse model;Mus;mutant;Mutation;Myelofibrosis;Myelogenous;Myeloproliferative disease;new therapeutic target;novel;novel therapeutics;Outcome;Patients;Pharmaceutical Preparations;Population;predictive modeling;pressure;Process;Production;Publishing;Research;response;Risk;Risk Reduction;Sampling;Schedule;Stimulus;Survival Rate;symptom management;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Translating;Treatment Protocols;treatment strategy;Work

PROJECT_TITLE: Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_STATE: CA

PHR: PROJECT NARRATIVE. A current challenge in cancer research is understanding tumor heterogeneity, a major cause of resistance to chemotherapy drugs as well as metastasis development. APOBEC3A and APOBEC3B have been identified as two of the major drivers of tumor heterogeneity by promoting the deamination of cytosine to uracil on DNA and inducing genomic mutations. The goal of this proposal is to uncover the molecular mechanisms that govern APOBEC3A and APOBEC3B regulation in cancer cells.

PI_NAMEs: BUISSON, REMI  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: anti-cancer research;apoB mRNA editing catalytic subunit;Attenuated;Automobile Driving;Binding;cancer cell;cancer cell differentiation;cancer genome;cancer type;Cells;Cessation of life;chemotherapy;Clinical;Clinical Treatment;Complex;Cytosine;Data;Deamination;Development;Disease Progression;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence Alteration;Drug resistance;Event;Evolution;Family;fighting;Genetic Transcription;Genetic Variation;Genome;Genomic Instability;genomic signature;Genomics;Goals;Heterogeneity;Individual;Induced Mutation;insight;Knowledge;Lead;Location;Malignant Neoplasms;member;Molecular;Mutagenesis;Mutation;Natural Immunity;Neoplasm Metastasis;neoplastic cell;next generation sequencing;Normal Cell;Outcome;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Population;prevent;Process;Prognosis;protein complex;Proteins;Regulation;replication stress;Research;Resistance;Sampling;Signal Pathway;Signal Transduction;Single Stranded DNA Virus;Single-Stranded DNA;Site;Source;Stat2 protein;Stress;Survival Rate;System;Technology;Therapeutic;therapeutic development;tumor;tumor heterogeneity;Uracil;Virus Replication;Writing

PROJECT_TITLE: Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Alternative pre-mRNA splicing is a crucial component of establishing appropriate gene expression programs that are unique to tissues and differentiated cell types. Defects in alternative splicing are known to associate with many human diseases. In this project we will analyze the mechanisms of regulated alternative splicing using a combination of experimental and computational approaches to provide detailed molecular insights into the control of gene expression and to identify novel disease targets.

PI_NAMEs: HERTEL, KLEMENS J (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Splice Site;Address;Alternative Splicing;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;cancer type;Cell Differentiation process;cell type;Cells;cis acting element;Code;combinatorial;conformer;Defect;Disease;Elements;Essential Genes;Event;Excision;Exons;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Diseases;genetic regulatory protein;Genetic Transcription;Goals;Growth;Heterogeneous-Nuclear Ribonucleoproteins;human disease;Human Genetics;Human Genome;improved;insight;Introns;Kinetics;Knock-in;Knock-out;Label;Lead;Link;Mediating;Messenger RNA;Metabolic;Methods;Modeling;Molecular;Molecular Biology;mRNA Precursor;mRNA Stability;Mutation;novel;Outcome;Pathway interactions;Positioning Attribute;premature;Process;programs;Proteins;Publishing;radioligand;reconstitution;Regulation;Reporter;Repression;Research;RNA;RNA Processing;RNA Splicing;Role;Site;Spliceosome Assembly Pathway;Structure;synthetic biology;System;Techniques;Testing;therapeutic target;tissue culture;Tissues;Transcript;transcriptomics;Translating;Translations;U1 Small Nuclear Ribonucleoprotein;Variant;Work

PROJECT_TITLE: Regulation and impact of alternative splicing in biology and disease

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: This grant application will investigate how truncated O-glycans on oncogenic glycoproteins promote pancreatic cancer progression and metastasis. Specifically, it will elucidate the role of Core 1 β1, 3-Galactosyltransferase (C1GALT1) in aberrant glycosylation of membrane-bound mucins and cancer stem cell markers and induce the early onset of metastasis in pancreatic cancer. Success in this study can be translated clinically by developing therapeutics (glycopeptide vaccines), and quantitative evaluation of truncated carbohydrate antigens in pancreatic cancer tissue can predict disease severity and help better manage pancreatic cancer patients.

PI_NAMEs: BATRA, SURINDER K.;PONNUSAMY, MOORTHY P. (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Acceleration;Acetylgalactosamine;Affect;Antigens;Appearance;Applications Grants;Binding;Cancer Etiology;cancer stem cell;carbohydrate structure;Carbohydrates;CD44 gene;Cessation of life;Clinical;clinical diagnosis;clinically significant;Co-Immunoprecipitations;CRISPR/Cas technology;Data;Death Rate;design;Disease;Disease Progression;Distant;Distant Metastasis;early onset;Galactose;Galactosyltransferases;Glycobiology;Glycopeptides;Glycoproteins;glycosylation;glycosyltransferase;Goals;Histocytochemistry;Human;improved;in vivo;Incidence;insight;Knock-out;KPC model;KRASG12D;Lectin;Liver;Lung;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Modeling;Molecular;Molecular Weight;mouse model;Mucin 1 protein;Mucins;Mus;Mutation;Neoplasm Metastasis;Normal Cell;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;O-Glycans Biosynthesis Pathway;Oncogenic;Organ;Organoids;pancreatic cancer cells;pancreatic cancer patients;Pathway interactions;Peptides;Peritoneum;Play;Polysaccharides;prevent;Quantitative Evaluations;Role;Sampling;Severity of illness;sialylation;stem cell biomarkers;stemness;Structure;success;sugar;Testing;Therapeutic;Tissues;TP53 gene;transcriptome sequencing;Translating;tumor progression;tumorigenesis;Tumorigenicity;Vaccines;Variant;Vertebral column

PROJECT_TITLE: Truncated O-glycan-dependent mechanisms inducing metastatic dissemination in pancreatic cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Individuals 65 and older can suffer from central or “hidden” hearing loss, which makes localizing sound and detecting speech in noise difficult, but does not affect hearing in quiet environments. This type of hearing loss is difficult to treat because of our lack of understanding about the mechanisms that lead to this hearing loss. In this proposal, we will look at age-related changes in the auditory brainstem and cochlea that may correlate with a decrease in spatial hearing performance to better understand the mechanisms of age-related hidden hearing loss.

PI_NAMEs: SERGISON, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Nerve;Acoustics;Affect;age related;age related changes;aged;Aging;aging population;Animal Behavior;Animal Model;Animals;Area;Auditory;Auditory area;Auditory Brainstem Responses;auditory pathway;Auditory Threshold;Axon;Behavior;Behavior assessment;behavior measurement;Binaural;binaural hearing;Biological Markers;Brain region;Brain Stem;Cell Nucleus;Cochlea;cochlear synaptopathy;Code;cohort;common symptom;Complex;Coupled;Cues;Data;Detection;Diagnosis;Diagnostic;Ear;Electrophysiology (science);Environment;extracellular;Functional disorder;Gerbils;Hair Cells;Hearing;hearing impairment;Hearing problem;hearing range;Hearing Tests;hidden hearing loss;Human;human old age (65+);Immunohistochemistry;Impairment;in vivo;Individual;inhibitory neuron;Inner Hair Cells;lateral superior olive;Link;Location;Measurement;Measures;Medial;medial superior olive;Nerve Fibers;Neurons;Noise;normal aging;normal hearing;otoacoustic emission;Outer Hair Cells;pathological aging;Pathway interactions;Patients;Performance;Peripheral;Phase;Physiological;Physiology;potential biomarker;prepulse inhibition;Probability;Process;Property;reduce symptoms;Reflex action;Research;response;Sensorineural Hearing Loss;Signal Transduction;Site;sound;Sound Localization;Speech;speech in noise;Stains;Structure;Synapses;Testing;Time;transmission process;trapezoid body;Work;young adult

PROJECT_TITLE: Aging impairs temporal fidelity in the auditory brainstem and underlies spatial hearing deficits

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project will contribute to the ongoing investigation of diet’s role in the association between air pollution exposure and type 2 diabetes. Using the comprehensive data collected by the Hispanic Community Health Study/Study of Latinos, our analysis centers around the Hispanic/Latino community, a historically underrepresented community in research. Understanding the interactions between diet and air pollution could help reduce incidence of T2D by identifying persons at higher risk and linking a healthy diet as a protective factor.

PI_NAMEs: KAUFMAN, JOEL DANIEL (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acculturation;Address;Air;Air Pollutants;Air Pollution;ambient air pollution;Ancillary Study;career;cohort;Communities;Data;Development;Diabetes Mellitus;diabetes risk;Diet;dietary;Environmental Risk Factor;experience;Exposure to;fine particles;Funding;good diet;health data;Healthy Eating;Heterogeneity;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hour;Incidence;indexing;Individual;Investigation;Latino;Latino Population;lifestyle factors;Link;Measures;Modeling;Nitrogen Dioxide;Nitrogen Oxides;Non-Insulin-Dependent Diabetes Mellitus;Ozone;Participant;Particulate Matter;Persons;Population;Prevalence;protective factors;Qualifying;Questionnaires;Research;Risk;Role;spatiotemporal;Training;young adult

PROJECT_TITLE: SOLAir: Environmental Factors and Diabetes Development in Latinos


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This research project will contribute to public health by providing essential data on the effects of recreational cannabis legalization on substance use and overdose rates. In an era where cannabis policies are rapidly evolving, understanding these impacts is critical for developing informed public health strategies. The findings will guide policymakers in creating interventions that improve health outcomes, lengthen life, and reduce illness and disability, especially among individuals most affected by these policies.

PI_NAMEs: ALLEN, LINDSAY  (contact)

PROJECT_TITLE: CE24-012 - The Impact of Recreational Cannabis Legalization on Substance Use Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (12)]


ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative For cells to grow and divide, protein complexes called ribosomes must be produced in a nuclear compartment called the nucleolus. The structure of the nucleolus is altered in many human diseases including more than 20 cancers, necessitating the need to understand how cells regulate nucleolar structure. The proposed study uses new imaging tools and genetic approaches to identify regulators of nucleolar structure in fission yeast, providing fundamental knowledge that can be applied to future studies in human cells.

PI_NAMEs: COCKRELL, ALEXANDRIA JANE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Architecture;Area;Automobile Driving;Bacterial DNA;Biogenesis;Biological Models;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell growth;Cell Nucleolus;Cell Physiology;Cells;Cellular biology;Chromosome Structures;Chromosomes;Classification;deletion library;DNA;DNA analysis;DNA-Binding Proteins;Exhibits;field study;Fission Yeast;Fluorescence Microscopy;Future;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Genome;genome-wide;Goals;high throughput analysis;Human;human disease;Image;Image Analysis;Imaging Device;imaging genetics;innovation;Interphase;Knowledge;Label;Maintenance;Malignant Neoplasms;Measures;Methods;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;Morphology;mutant;Neurodegenerative Disorders;novel;novel strategies;Nuclear;Nucleolar Organizer Region;nucleolar organizing region;Nucleolar Proteins;Organelles;Organism;Physiologic pulse;Process;Production;Protein Biosynthesis;protein complex;Proteins;Quantitative Microscopy;Research;Ribosomal DNA;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Processing;Role;Saccharomycetales;Structure;Testing;tool;Transcript;Variant

PROJECT_TITLE: The identification of fundamental molecular regulators of ribosomal DNA and nucleolar organization in fission yeast


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Lymphatic Research;Vaccine Related;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Immunotherapies hold immense potential to provide cures for many cancers and metastatic disease, but the complexity of activating and sustaining anti-tumor immune responses will necessitate combinatorial treatment regimes and a better understanding of how the tumor microenvironment (TME) affects response. Here we develop a in vitro model of the tumor-immune circuit which allows precise control over spatial, molecular, cellular, and mechanical aspects of the TME that affect response to immunotherapy, and use it for both mechanistic studies as well as high-throughput predictive screening of immune therapies in a tumor- or patient- specific manner.

PI_NAMEs: SWARTZ, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 4T1;Adjuvant;Adopted;Adverse event;Affect;Affinity;Allogenic;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Antigen Presentation;Antitumor Response;Autologous;Binding;Biological Assay;Biomechanics;Breast Cancer Model;cancer cell;cancer immunotherapy;Cancer Model;cancer type;Cancer Vaccines;CCL21 gene;CCL4 gene;cell killing;Cell Line;Cell Therapy;Cells;Characteristics;checkpoint inhibition;chemokine;Chemosensitization;chimeric antigen receptor T cells;Chimeric Proteins;Clinic;Clinical;clinical translation;clinically relevant;Collaborations;Collagen;Combination immunotherapy;combinatorial;Contralateral;Cross Presentation;CXCL10 gene;CXCL9 gene;cytokine;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Devices;Disease;Distal;dosage;draining lymph node;efficacy evaluation;efficacy testing;Engineering;Exclusion;Exhibits;Experimental Designs;Grant;high throughput screening;Imiquimod;Immune;immune cell infiltrate;immune checkpoint blockade;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;immunotoxicity;improved;In Vitro;in vitro Model;in vivo;Individual;Infiltration;Inflammatory;Irradiated tumor;Leukocytes;Ligands;Ligation;lymph flow;Lymphangiogenesis;Lymphatic;Malignant Neoplasms;Maps;Mechanics;Melanoma;Modeling;Molecular;Monitor;Morphology;mouse model;Mus;neoantigens;Neoplasm Metastasis;neoplastic cell;Nitric Oxide;novel;Outcome;overexpression;parent grant;Patients;Peptide Vaccines;personalized approach;PGF gene;Play;Primary Neoplasm;Process;Prognosis;programmed cell death ligand 1;prophylactic;RANTES;Recombinants;recruit;release of sequestered calcium ion into cytoplasm;Research;Research Project Summaries;response;Role;screening;Side;Signal Transduction;Site;Stratification;survival outcome;synergism;System;T-Cell Activation;T-Lymphocyte;Therapeutic;TNFRSF5 gene;TNFSF5 gene;Transfection;Transforming Growth Factor beta;Translating;Treatment Efficacy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumorigenesis;Vaccination;vaccine platform;Vaccines;Vascular Endothelial Growth Factor C;VEGFC gene;von Willebrand Factor;Whole Cell Vaccine;XCL1 gene

PROJECT_TITLE: Probing cellular, molecular and biomechanical barriers to immunotherapy in the tumor microenvironment with organotypic in vitro models of the tumor-lympho-immune interface


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Prolonged exogenous opioid exposure leads to dysregulation of brain regions associated with reward and motivation. In this proposal, we seek to characterize the gene expression changes resulting from chronic opioid intake at single-cell resolution, and to map alterations to neuronal activity patterns throughout the brain after a period of withdrawal and drug re-exposure. These experiments will expand upon the current understanding of opioid use disorder, with the goal of identifying novel therapeutic targets.

PI_NAMEs: BURKE, CASSIDY TAYLOR (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Acute;Address;Atlases;Automobile Driving;Binding;Brain;Brain region;Cell Nucleus;cell type;Cells;Chronic;cohort;Consumption;Development;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dose;drug craving;Drug Exposure;drug reward;drug seeking behavior;Drug Tolerance;Drug Withdrawal Symptoms;effective therapy;Escalator;experimental study;Fentanyl;fentanyl exposure;fentanyl self-administration;fentanyl use;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Globus Pallidus;Goals;Home;Hour;Human;Hypothalamic structure;Image;Immediate-Early Genes;improved;Individual;Intake;Interneurons;Intraperitoneal Injections;Knowledge;Label;large datasets;Light;Long-Term Effects;Longitudinal Studies;Maps;Mediating;Mental disorders;Microscope;Microscopy;Midbrain structure;Molecular;Monitor;Motivation;Mus;neural;neural circuit;neuroadaptation;Neuroglia;neuromechanism;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nucleus Accumbens;Opioid;opioid exposure;opioid misuse;opioid mortality;Opioid Receptor;opioid use;opioid use disorder;Oral;Pattern;Perfusion;Pharmaceutical Preparations;Physicians;Play;Protocols documentation;Receptor Activation;Recording of previous events;Resolution;reward circuitry;reward processing;Rewards;Rodent Model;Role;Scientist;Self Administration;Substance Use Disorder;Therapeutic Intervention;Time;Tissues;Training;transcriptome sequencing;Transgenic Mice;Variant;Ventral Tegmental Area;Visualization;Water;Withdrawal

PROJECT_TITLE: Impact of chronic, voluntary fentanyl intake on single-cell gene expression and brain-wide neuronal activity patterns

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PHR: Narrative Home for exceptional science and of internationally renowned cancer experts and supported by a comprehensive clinical research infrastructure, the Robert H. Lurie Comprehensive Cancer Center of Northwestern University (LCC) is will continue leadership of and participation in NCTN trials as a high performing LAPS, recruiting patients in the Chicago metropolitan area to trials aiming to improve the lives of people with cancer.

PI_NAMEs: BENSON, AL B (contact);MATEI, DANIELA E

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Advanced Malignant Neoplasm;American College of Radiology Imaging Network;Ancillary Study;Area;Cancer Intervention;Chicago;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Eastern Cooperative Oncology Group;Faculty;Goals;Home;improved;Infrastructure;Institution;inter-institutional;International;Lead;Leadership;Malignant Neoplasms;metropolitan;Patient Recruitments;Patients;Persons;Productivity;Recording of previous events;recruit;Research Infrastructure;Resources;Role;Science;Scientific Advances and Accomplishments;senior faculty;Site;Southwest Oncology Group;Universities

PROJECT_TITLE: Northwestern University Lead Academic Participating Site - Revision -5S2


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: NARRATIVE Adenomas are early lesions of colorectal cancer, but only a subset of adenomas progress and become cancer. In light of the well characterized clinical natural history of adenomas, we plan to study them as early lesions and to determine the mechanisms involved in the formation and progression of early precancerous lesions. We hypothesize that adenoma progression requires a suite of hallmark behaviors and that these behaviors are induced by adenoma autonomous factors (e.g. cancer driver gene mutations) and adenoma nonautonomous factors from the “primed colon” or adenoma microenvironment. Our proposed studies will integrate basic and translational cancer research projects to iteratively examine the direct causal relationships and interactions of adenomas, the colon “primed” microenvironment, and host-systemic factors as “co-organizers” of adenoma initiation and/or progression.

PI_NAMEs: DEY, NEELENDU ;GRADY, WILLIAM MALLORY (contact);HALBERG, RICHARD BROTT

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Architecture;Atlases;Basic Cancer Research;Behavior;Biological Markers;Biology;Cancer Etiology;cancer genetics;Cancer Research Project;cancer type;Cells;Cessation of life;Clinic;Clinical;clinical application;cohort;Collaborations;Colon;colon cancer patients;Colonic Adenoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Data Set;deep sequencing;DNA Sequence Alteration;dysbiosis;Epigenetic Process;Epithelial Cells;experience;Fibroblasts;Gene Mutation;Goals;gut microbiome;Human;human disease;Immune;Individual;Indolent;innovation;Lesion;Light;Malignant Neoplasms;methylation pattern;methylome;microbiome;Mission;Molecular;mouse model;Multiomic Data;mutant;Mutation;Natural History;novel;Pathogenesis;Patients;Persons;Positioning Attribute;premalignant;Recording of previous events;Research Personnel;risk prediction;Science;senescence;Sessile Lesion;Technology;Testing;Tissues;translational cancer research;Translational Research;Translations;Tumor Promotion

PROJECT_TITLE: Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Malic enzyme 2 is frequently deleted in pancreatic cancer and its deletion correlates with poor patient prognosis. Here, we propose experiments that will explore the molecular basis of malic enzyme 2 loss-induced oncogenesis of pancreatic cancer. Our studies will also identify novel therapies for patients with malic enzyme 2 loss and will lead to new clinical treatments for human pancreatic cancer.

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Biological Markers;cancer initiation;Cell Culture Techniques;cell growth;CELSR1 gene;chemotherapy;Clinical Treatment;Development;Diagnosis;effective therapy;Effectiveness;experimental study;Genetic;Genetically Engineered Mouse;Goals;high throughput screening;Human;Implant;improved;innovation;Invaded;Lesion;MADH4 gene;malic enzyme;Malignant neoplasm of pancreas;Mediating;Modeling;Molecular;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Organoids;Other Genetics;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic PDX models;pancreatic tumorigenesis;patient derived xenograft model;patient prognosis;Patients;personalized biomarkers;personalized medicine;personalized therapeutic;Prognosis;response;Series;Signal Pathway;Signal Transduction;Treatment Efficacy;tumor growth;tumor progression;Tumor Suppression;tumorigenesis

PROJECT_TITLE: Molecular Basis of ME2-mediated Tumor Suppression in Pancreatic Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: The overarching goal of this study is to identify effective metabolic based diagnostic and therapeutic strategies to improve the overall survival of patients with Non-small cell lung cancer (NSCLC). We propose to investigate the positron emission tomography (PET) tracer, 18F-BnTP as a novel metabolic diagnostic and to develop metabolic based therapeutic strategies targeting oxidative mitochondrial metabolism in therapy resistant KRAS/LKB1 and EGFR mutant lung tumors. This work represents a new approach to overcoming therapy resistance in KRAS/LKB1 and EGFR mutant lung tumors – one in which the tumor’s metabolic and bioenergetic dependencies are profiled and then selectively targeted.

PI_NAMEs: SHACKELFORD, DAVID B (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;advanced disease;Apoptosis;base;Bioenergetics;Biological Markers;Biopsy;cell growth;Cell Respiration;Cell Survival;Cellular Stress;checkpoint therapy;Chemicals;Classification;Complex;cyclophilin D;Dependence;Diagnostic;Disease;Dissection;driver mutation;Epidermal Growth Factor Receptor;Functional Imaging;Genetically Engineered Mouse;Glucose;glucose metabolism;Glycolysis;Goals;Health;Heat shock proteins;Heat-Shock Proteins 90;Human;image guided;imaging probe;Immunotherapy;improved;in vivo;in vivo evaluation;in vivo imaging;inhibitor;Inner mitochondrial membrane;Knowledge;KRAS2 gene;lipophilicity;Lung Adenocarcinoma;Lung Neoplasms;Maintenance;Malignant Neoplasms;Maps;Measurement;Membrane Potentials;Mentors;Metabolic;Mitochondria;mitochondrial membrane;mitochondrial metabolism;mutant;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;Oncogenic;Oxidative Phosphorylation;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Physiological;Play;Positron-Emission Tomography;Primary Neoplasm;Process;protein folding;Proteins;Rationalization;Research;Resistance;Resistance development;Role;Sampling;Site;STK11 gene;Stress;Structure;superresolution microscopy;targeted treatment;Testing;Therapeutic;therapy resistant;Tissues;Tracer;tumor;tumor initiation;tumor progression;uptake;Work

PROJECT_TITLE: In vivo imaging of mitochondria structure and function in therapy resistant lung tumors


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Through this work, we aim to understand how site-, region-, and network-specific brain dynamics during sleep change in relation to the clinical and pathologic trajectory of Alzheimer’s disease. Characterizing these patterns will be integral in early detection of AD using sleep-related biomarkers, development of sleep interventions to slow disease progression, and electrophysiological monitoring of amyloid/tau-centric treatments.

PI_NAMEs: DICKERSON, BRADFORD C;PRERAU, MICHAEL J;PURDON, PATRICK L. (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anatomy;basal forebrain;Biological Markers;Brain;Cerebrospinal Fluid;Cerebrum;Clinical;Cognitive;Coupling;Data;Dementia;density;Development;Disease Progression;Early Diagnosis;Elderly;Electroencephalography;Electrophysiology (science);Frequencies;Functional Magnetic Resonance Imaging;Future;Human;improved;Intervention;Link;locus ceruleus structure;Magnetic Resonance Imaging;Measures;medial temporal lobe;Memory;Methodology;Methods;mild cognitive impairment;Modeling;Monitor;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroimaging marker;neuroinflammation;neuromelanin;neuropathology;non rapid eye movement;novel;Pathologic;Pathology;Pattern;Performance;Phase;Positron-Emission Tomography;pre-clinical;Process;Property;REM Sleep;Resolution;Scalp structure;signal processing;Site;Sleep;sleep spindle;Slow-Wave Sleep;Source;source localization;tau aggregation;tau Proteins;therapy development;Thick;Time;tool;Uncertainty;Variant;Work;β-amyloid burden

PROJECT_TITLE: Characterizing sleep brain dynamics associated with Alzheimer's disease pathology and progression in humans using EEG source localization and PET


ORG_CITY: DAVIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Medications for opioid use disorder (MOUD) can reduce overdose mortality risk in patients with opioid use disorder, and emergency department (ED) have been urged to prioritize MOUD initiation for patients with untreated OUD. In California, a novel program emphasizing low-barrier ED-initiated MOUD (the CA Bridge program) disseminated to most EDs statewide from 2018-2022. This project will use California Medicaid data linked to death records to evaluate the impact of CA Bridge dissemination on short- and long-term MOUD use, outpatient engagement, and fatal and non-fatal overdose risk, elucidating the potential public health impacts of ED-based substance use services in the vulnerable Medicaid population.

PI_NAMEs: FENTON, JOSHUA J (contact)

PROJECT_TITLE: CE24-012 - Rigorous Evaluation of California Policies to Disseminate Emergency Department-based Services for Opioid Use Disorder


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: PROJECT NARRATIVE There is an urgent need for a better vaccine to combat the global threat of Tuberculosis. Gamma delta (γδ) T cells, which can recognize mycobacterial lipids and interact with diverse cell types to initiate a protective response, are an interesting target for vaccination. In this proposal, we will use advanced computational techniques and novel in vitro systems to analyze mechanisms used by γδ T cells to promote control of Mtb infection, which will inform future vaccination efforts.

PI_NAMEs: TAPPEN, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: adaptive immune response;Animal Model;Animals;Antigens;Binding;butyrophilin;Cell Communication;Cell Maturation;cell type;Cells;Cellular Structures;Cessation of life;Characteristics;Clinical;Clone Cells;Coculture Techniques;cohort;Cohort Studies;combat;Computational Technique;Computer Analysis;cytokine;Data;Data Set;Dendritic Cells;Development;Disease;experimental study;Flow Cytometry;Future;Genus Mycobacterium;Granuloma;Histocompatibility;Human;Hydrophobicity;Immune response;Immunity;improved;In Vitro;Infiltration;insight;interest;Ligands;Lipid Binding;Lipids;Lung;Mediating;Methods;Microscopy;Modeling;Molecular;Molecular Analysis;Mucous Membrane;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;nonhuman primate;novel;novel strategies;novel therapeutics;Organoids;Palatine Tonsil;pathogenic bacteria;Pattern;Phenotype;Reaction;response;Role;Shapes;single-cell RNA sequencing;small molecule;System;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Tissues;Tonsil;Transfection;Tuberculosis;Vaccination;vaccine trial;Vaccines;γδ T cells

PROJECT_TITLE: Investigating the role of gamma delta (γδ) T cells in the control of Mycobacterium tuberculosis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: RENO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Our “real-world” approach to the study of visual perception is relevant to public health because it will provide fundamental new insights into how realistic stimulus displays can improve perception, learning, and cognition, in healthy adults and children, and in brain-damaged individuals. The research will shed new light on perceptual abilities that are spared, but as yet poorly understood, in patients with visual agnosia, ultimately leading to the development of more effective assessment and rehabilitation approaches for patients with sensory, perceptual, and motor deficits, thereby reducing the burdens of human disability.

PI_NAMEs: WALSH-SNOW, JACQUELINE C (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Bringing the real-world into cognitive neuroscience: from images to real objects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine

PHR: PROJECT NARRATIVE Among the 40% of patients with an HLA-B44 supertype allele, greater clinical activity of programmed cell death 1 (PD-1) inhibitors is seen when mutations lead to peptides in which a neutral or positively charged amino acid is substituted with a negatively charged amino acid, presumably based on favorable binding to the positively charged HLA-B44 binding pocket. We propose comprehensive studies to characterize the effects of these specific mutational events on the tumor microenvironment in early stage non-small cell lung cancer. This will serve as a vehicle to develop the career of Maria Velez, a junior faculty member, facilitating her ability to become competitive for career development awards, and eventually, a career as an independent investigator directing her own research team.

PI_NAMEs: GARON, EDWARD B (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Agreement;Algorithms;Alleles;Amino Acid Substitution;Amino Acids;anti-tumor immune response;antigen binding;Antigen Presentation;Antigens;bak protein;Binding;Biological Markers;Biology;biomarker identification;Biometry;Cancer Etiology;Cancer Patient;career;Cessation of life;Charge;chemotherapy;Clinical;clinical care;Clinical Data;Clinical Trials;clinically relevant;Combination Drug Therapy;combinatorial;Data;Development;Disease;Disease Progression;Disease-Free Survival;Dissociation;Electrostatics;Epidermal Growth Factor Receptor;Ethnic Population;Evaluation;Event;exome sequencing;Faculty;Gene Expression;Gene Expression Profile;genetic signature;Goals;HLA Antigens;Immune;immune checkpoint;Immune response;Immunofluorescence Immunologic;Immunologic Markers;Immunologics;improved;In complete remission;Inflammatory;inhibitor;innovation;K-Series Research Career Programs;Lead;Learning;Ligands;Malignant neoplasm of lung;Medical Oncologist;member;Methods;Minority;Mismatch Repair Deficiency;Modeling;Modernization;Mutation;Neoadjuvant Therapy;neoantigens;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;outcome prediction;Parents;Pathologic;Patient Selection;Patients;Peptides;Peripheral Blood Mononuclear Cell;Population;Positioning Attribute;predict clinical outcome;predictive marker;Predictive Value;Prevalence;programmed cell death ligand 1;programmed cell death protein 1;racial population;Research;Research Personnel;Research Project Grants;response;Role;Sampling;single-cell RNA sequencing;Slide;Sorting;spatial relationship;Specimen;Techniques;Testing;The Cancer Genome Atlas;Time;Training;transcriptomics;Translating;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;United States;Up-Regulation

PROJECT_TITLE: HLA B44 motif neoepitopes in NSCLC: Evaluating their effects on the TME and adding them to established markers in a model to predict durable benefit from PD- 1 inhibition with and without chemotherapy

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rehabilitation

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Premature birth places infants at risk for movement disorders as a result of abnormal motor and sensory experiences with an immature brain. The goal of the current proposal is to use rigorous measurements to track motor and sensory development in relation to brain activity to understand movement deficits. Understanding how sensorimotor systems develop will provide important information for developing evidence-based therapies for infants at-risk for developmental disabilities.

PI_NAMEs: FERRE, CLAUDIO LUIS (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Affect;Age;Age Months;Animal Model;Area;Award;Behavior;Behavioral;Birth Place;Brain;Brain Diseases;Brain Injuries;Calibration;career;Career Choice;career development;Cerebral Palsy;Child;Childhood;Clinical;clinical diagnosis;design;Development;Development Plans;Developmental Disabilities;Disabled Children;Early Intervention;evidence base;Evidence based treatment;Exhibits;expectation;experience;Fiber;Foundations;Frequencies;functional improvement;functional independence;functional near infrared spectroscopy;Gestational Age;Goals;grasp;Growth;Imaging Techniques;Impairment;improved;Infant;insight;Intervention;Knowledge;Lateral;Life;Life Cycle Stages;Literature;longitudinal analysis;Longitudinal Studies;Measurement;Measures;Mentorship;Mission;Modeling;Motor;Motor Activity;motor behavior;motor control;Motor disability;motor impairment;motor recovery;Motor Skills;Movement;Movement Disorders;Muscle Weakness;National Institute of Neurological Disorders and Stroke;Neonatal Brain Injury;Nervous System;Nervous System Disorder;neural;neurological rehabilitation;neurophysiology;novel;novel therapeutics;optical imaging;Pathway interactions;Pattern;Perception;Positioning Attribute;Poverty;Pregnancy;Premature Birth;Premature Infant;prenatal;prevent;programs;Quality of life;Recovery;repaired;Research;Research Personnel;response;Risk;sensor;Sensorimotor functions;sensorimotor system;Sensory;Sensory impairment;sensory system;social engagement;Spinal Cord;Stretching;System;Teacher Professional Development;Time;tool;Training;trend;Unit of Measure;Uterus;Vulnerable Populations;wearable device

PROJECT_TITLE: Codevelopment of Sensory and Motor Function in Infants at Risk for Cerebral Palsy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Object sensing and manipulation require selective focus of tactile sensory signals from specific locations on the hand. Here, we determine how selective attention implements mechanisms of gain suppression to filter out irrelevant tactile information, and enhance sensory representations encoding attended cutaneous stimuli. Results from this study will provide fundamental insights into how distracting sensory information is discarded in brain, which may lead to a better understanding of the underlying circuits mediating tactile perceptual deficits in Autism and Attention Deficit Hyperactivity Disorder populations. Our studies will also have a direct translational impact on Brain-Machine-Interface (BMI) solutions that are specific to neuroprosthetic applications.

PI_NAMEs: GOMEZ-RAMIREZ, MANUEL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: analytical method;Animals;Area;Attention;Attention deficit hyperactivity disorder;attentional control;autism spectrum disorder;Award;Behavior;Behavioral;Brain;brain machine interface;Calcium;career;cell cortex;Cells;Central Nervous System;Cities;Cognitive Science;college;Communication;Cortical Column;Cutaneous;D Cells;Data;Development;discrimination task;Doctor of Philosophy;Electrodes;Electrophysiology (science);Ensure;Environment;experimental study;Faculty;Fellowship;Fingers;flexibility;Functional Magnetic Resonance Imaging;Genetic;Goals;Grant;Hand;haptics;Human;Human Resources;Image;Injections;insight;Interneurons;Learning;Link;Location;Macaca mulatta;Manuscripts;Maps;Mediating;Mentors;Methods;Modality;Modeling;Monitor;Monkeys;Mus;neocortical;neural;neural circuit;Neurons;neuroprosthesis;neuroregulation;neurotransmission;New York;nonhuman primate;Optical Methods;optogenetics;Perception;Personnel Management;Persons;Play;Population;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;receptive field;receptor;Recurrence;Research;Research Training;response;Role;role model;Scalp structure;selective attention;senior faculty;Sensory;sensory stimulus;Series;Signal Transduction;simulation;Skin;somatosensory;Somatosensory Cortex;Somatostatin;Stimulus;System;Tactile;Techniques;Testing;Texture;theories;Time;Training;translational impact;Universities;vibration;Viral;Writing

PROJECT_TITLE: The Neural Basis of Active Sensory Gain Suppression in the Somatosensory System


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Stroke

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Focal cerebral arteriopathy (FCA) causes strokes in previously healthy children, leaving them with life-long motor and cognitive disabilities. The Focal Cerebral Arteriopathy Steroid (FOCAS) trial will determine which of two current strategies for treating FCA provides these children the best possible outcomes.

PI_NAMEs: ELKIND, MITCHELL S;FULLERTON, HEATHER J (contact)

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Adverse effects;Advocacy;Affect;American;arm;Arterial Disorder;Arteries;Aspirin;Attitude;Benefits and Risks;Blinded;Brain Injuries;cerebral arteriopathy;Cerebral hemisphere hemorrhage;Characteristics;Chickenpox;Child;Childhood;Childhood stroke;Clinical;Clinical Trials;cognitive disability;cohort;Communities;comparative effectiveness trial;compare effectiveness;Consensus;Dangerousness;Data;Diagnosis;Diagnostic;Disadvantaged;Disease;Disease Progression;Distal;Dose;Early treatment;Enrollment;Etiology;European;Evolution;Family;Goals;Hemorrhage;Herpesviridae;Herpesviridae Infections;Hypertension;Image;improved outcome;Infarction;Infection;Inflammatory;Inflammatory Response;Internal carotid artery structure;International;Ischemic Brain Injury;Ischemic Stroke;Measures;Meta-Analysis;Minority;Motor disability;Natural History;Neurological outcome;Neurologist;Outcome;Outcome Measure;Patients;Pharmacotherapy;Physicians;post stroke;preference;prevent;primary endpoint;primary outcome;prospective;Publication Bias;Publishing;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Research Priority;Safety;safety outcomes;secondary endpoint;secondary outcome;Severities;Severity of illness;Site;Stenosis;Steroids;Stroke;Structure of trigeminal ganglion;Sum;Supportive care;Surveys;Testing;Time;time interval;Training;Transient Ischemic Attack;trial design;Uncertainty;Viral;Virus

PROJECT_TITLE: FOcal Cerebral Arteriopathy Steroids (FOCAS) Trial


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Genetics;Mental Health;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The use of cocaine or methamphetamine often leads to poor health outcomes, including cardiovascular dysfunction and overdose-related mortality. Discovering treatments for stimulant use disorder (SUD) is a pressing task for researchers, as there are currently no FDA-approved medications to treat SUD. Our group has identified a brain protein, RGS12, that may hold promise as a potential target for SUD medications, and we propose work that will validate the utility of RGS12-targeting medications.

PI_NAMEs: WHITE, ALLISON  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: addiction;Affect;alcohol use disorder;Amphetamines;Animals;anxiety-like behavior;Astrocytes;Behavior;behavior test;Behavioral;Behavioral Paradigm;behavioral study;Biochemical;Biochemistry;Brain;Brain region;brain tissue;Cardiovascular system;career;Carrier Proteins;cell type;Cells;Cellular biology;Cessation of life;Cocaine;cocaine use;Cocaine use disorder;Cocaine withdrawal;Complex;Corpus striatum structure;Data;design;disease model;Dopamine;dopamine transporter;Drug Targeting;druggable target;Educational process of instructing;Evaluation;Exhibits;experimental study;FDA approved;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Modified;Genotype;Goals;graduate student;Grooming;improved;Incidence;Individual;insight;Intervention;Intravenous;Knockout Mice;Label;Laboratories;Laboratory Animals;Learning;Locomotion;Maintenance;Measures;Mediating;Mental disorders;Mentors;Methamphetamine;Modeling;Molecular;Molecular Biology Techniques;Molecular Target;monoamine;mortality;mouse model;Mus;Neurobiology;neuropsychiatric disorder;new therapeutic target;Nucleus Accumbens;Operative Surgical Procedures;Overdose;Pharmaceutical Preparations;Phase;poor health outcome;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Procedures;Process;protein expression;Proteins;psychostimulant;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resistance;RGS Proteins;Role;Running;Self Administration;Serotonin;serotonin transporter;single-cell RNA sequencing;skills;Stimulant;stimulant use;stimulant use disorder;Stress;Stress and Coping;Techniques;Testing;Tissues;tool;Tracer;Training;training opportunity;transcriptome;treatment strategy;United States;uptake;Wild Type Mouse;Work;Writing

PROJECT_TITLE: Role of parasubthalamic astrocytic dysfunction in alcohol use disorder


NIH_SPENDING_CATS: Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This proposal seeks to identify the effects of the 20 proteinogenic amino acids and other related compounds on cellular processes. The experiments described in this proposal will begin to enlighten us on such effects and may provide insight into amino acid sensing and metabolism. Additionally, the data collected will provide a valuable resource to the scientific community to pursue alternate treatments in conditions with amino acid imbalances, such as cancer, diabetes, and inborn errors of metabolism.

PI_NAMEs: JACOBS, KYLIE  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Affect;Amino Acid Permease;Amino Acid Transporter;Amino Acids;Arrestins;Biological Models;Branched-Chain Amino Acids;Buffers;Carbon;Cardiovascular Diseases;cell growth;Cell membrane;Cell Physiology;Cell surface;Cells;Communities;Cysteine;Data;deprivation;design;Diabetes Mellitus;Disease;Dose;Drug Targeting;Essential Amino Acids;experimental study;Exposure to;Gene Modified;Genetic;genetic manipulation;Genetic Screening;Genetic Transcription;Growth;Health;Heart Diseases;Homeostasis;Human;Image;Impairment;Inborn Errors of Metabolism;insight;Insulin Resistance;Knowledge;lipidomics;Lysosomes;Maintenance;Malignant Neoplasms;Mammalian Cell;Membrane Transport Proteins;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methionine;mutant;Mutate;Neutral Amino Acids;Nitrogen;Nucleotides;Organelles;Organism;overexpression;Pathway interactions;Patients;permease;Phenylketonurias;Play;Production;Proliferating;Protein Biosynthesis;Proteins;Recycling;Regulation;Research;Resources;response;Role;Saccharomyces cerevisiae;Saccharomycetales;sensor;Serum;Signal Transduction;Signaling Molecule;Source;Specificity;Starvation;System;Systems Biology;Toxic effect;transcriptome sequencing;transcriptomics;Translations;uptake;Vacuole;yeast genetics;Yeasts

PROJECT_TITLE: A systems biology approach to elucidating mechanisms underlying amino acid toxicities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Peripheral nerve injuries (PNI) put motoneurons (MNs) at risk of cell death, thereby limiting an individual’s potential for a full functional recovery. This project aims to identify microglial-MN interactions and cellular communication mechanisms that may govern MN fate following a PNI. Our research is critical for therapeutic advancement in MN disease, improving patient outcomes, and may be transferable to other neuropathologies.

PI_NAMEs: POTTORF, TANA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;Amyotrophic Lateral Sclerosis;Axotomy;Behavior;Binding;Brachial plexus structure;CASP3 gene;Cd68;Cell Count;Cell Death;Cells;Central Nervous System;Cessation of life;Characteristics;Communication;Confocal Microscopy;Consumption;Cytoplasmic Granules;Data;disability;Disease;Endocytosis;Environment;Excision;Fc Immunoglobulins;Fc Receptor;Filopodia;Foundations;glial activation;Health Status;Histologic;Homeostasis;Image;Immune;improved;In Situ Nick-End Labeling;Individual;injured;Injury;Intervention;Investigation;Knockout Mice;Label;Life Experience;Literature;Lysosomes;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Methods;Microglia;Microscopy;migration;Modeling;Molecular;Monitor;Morphology;Motor;Motor Neurons;mouse model;Mus;Muscle;Natural regeneration;Nerve Degeneration;Neuronal Injury;Neurons;neuropathology;neuroprotection;Newborn Infant;particle;Pathway interactions;Patient-Focused Outcomes;Peripheral nerve injury;Phagocytes;Phagocytosis;Phenotype;Phosphorylation;preservation;Process;Proliferating;Proteins;receptor;Recovery of Function;regenerative;Research;Resolution;response;Risk;Role;Sampling;Signal Transduction;Slice;Spinal Cord;Stains;superresolution microscopy;Surface;Surveys;SYK gene;Testing;Therapeutic;Therapeutic Intervention;Time;TP53 gene;Transfection;TREM2 gene;two-photon;ultra high resolution;uptake;Visualization;Western Blotting

PROJECT_TITLE: Microglial Activity on Injured Motoneurons


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Epstein-Barr Virus (EBV) infects nearly all adults on the planet and can alter host cell function to maintain a latent or lytic life cycle, promoting recurrent infections in the oral mucosa that can lead to tumorigenesis in immune compromised individuals. While diverse stimuli can reactive EBV, the response is often heterogeneous and what governs this process at the single cell level is poorly understood. Therefore, the proposed studies will elucidate host factors that restrict complete EBV lytic reactivation, which can help lead to better therapies for EBV- associated diseases.

PI_NAMEs: HAYNES, LAUREN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Area;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Benign;Biology;BZLF1 gene;Cancer cell line;Cell Communication;Cell Death;Cell Fraction;Cell Physiology;Cells;Clinical;Clinical Trials;cytokine;Data;Data Set;DNA Damage;EBV-associated disease;effective therapy;Enzyme-Linked Immunosorbent Assay;Epstein Barr Virus B lymphoma cell;Epstein-Barr Virus-Related Malignant Neoplasm;Equilibrium;experimental study;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;Herpesviridae;Histone Deacetylase Inhibitor;HIV;Host Defense Mechanism;Human;Human Herpesvirus 4;Hypoxia;IL6 gene;Immediate-Early Genes;Immune;Immunocompetent;immunodeficiency;In Vitro;in vivo;Individual;infected B cell;Infection;Infectious Mononucleosis;Integration Host Factors;Intercellular adhesion molecule 1;Interleukin 6 Receptor;Interleukin-6;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;latent infection;Lead;Life;Life Cycle Stages;Lymphoma;Lytic;lytic gene expression;Lytic Phase;Lytic Virus;Malignant Neoplasms;Memory B-Lymphocyte;Nature;Neoadjuvant Therapy;neoplastic cell;NFKBIA gene;Oral cavity;oral cavity epithelium;oral infection;Oral mucous membrane structure;Outcome;particle;Pathway interactions;Patients;Phase;Phenotype;Planets;plasma cell differentiation;Population;Process;Production;Productivity;Proteins;reactivation from latency;recurrent infection;Refractory;Regulation;Reporter;Research;response;Rest;RNA;Role;Saliva;Signal Transduction;single-cell RNA sequencing;Site;Sorting;STAT3 gene;Stimulus;stressor;Testing;therapeutically effective;Time;Transfection;transmission process;tumorigenesis;Viral;Viral Genes;Viral Genome;Virus;Virus Diseases;Visualization;Work

PROJECT_TITLE: Defining host mechanisms that restrict EBV lytic reactivation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Neurosciences;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: In 2020, our research team completed a multicenter phase III randomized controlled trial for primary stroke prevention in children with sickle anemia, demonstrating that children with an annual 10% stroke risk because of a high velocity of blood flow in their brain could be treated with either low or moderate dose hydroxyurea for a significant decrease in strokes. We propose an open-label, single-arm, type I hybrid trial (phase IV trial) for primary stroke prevention initially with low-dose hydroxyurea and subsequently with moderate-dose hydroxyurea based after at least two severe pain events requiring physician contacts during the trial and assessment of ways to maintain the sustainability of stroke prevention programs. We will conduct a cost- effective analysis to determine the sustainability, relative cost, and effectiveness of the hydroxyurea dose on stroke prevention and healthcare utilization.

PI_NAMEs: ABDULLAHI, SHEHU UMAR;DEBAUN, MICHAEL R. (contact);HIKIMA, MUSTAPHA SHU'AIBU;HUSSAIN, NAFIU ;KING, ALLISON A

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acute Pain;Adoption;American Society of Hematology;Anemia;Area;arm;Assessment tool;Blood Cell Count;Blood Flow Velocity;Brain;Cephalic;Child;Childhood;Clinic Visits;Clinical;Clinical Trials;cost;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;cost-effectiveness ratio;Data Coordinating Center;Dimensions;Dose;Double-Blind Method;Effectiveness;effectiveness evaluation;effectiveness testing;EuroQOL;Event;evidence based guidelines;Fogarty International Center;follow-up;Funding;Goals;Guidelines;health care model;health care service utilization;high risk;Hospitalization;hybrid type 1 trial;hydroxyurea;implementation evaluation;Incidence;incremental cost-effectiveness;Intervention;Judgment;Literature;Low income;Maintenance;Measures;member;Methods;multidisciplinary;National Institute of Neurological Disorders and Stroke;neuroimaging;Neurology;Nigeria;Nigerian;Nurses;open label;Outpatients;Pain;Participant;pediatrician;Persons;Phase;phase III trial;phase IV trial;Physicians;Population;prevent;Prevention program;preventive intervention;primary outcome;Principal Investigator;Publishing;Quality-Adjusted Life Years;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;relative cost;Relative Risks;Research;Risk Reduction;routine care;Sample Size;screening;secondary outcome;Sickle Cell Anemia;sickling;skills;standard care;Stroke;stroke incidence;Stroke prevention;stroke risk;Testing;Time;treatment group;trial comparing;Visit

PROJECT_TITLE: Stroke Prevention in Nigeria: SPRING 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: PROJECT NARRATIVE Heart failure (HF) affects over 6.2 million adults in the United States and is implicated in more than 300,000 deaths per year. Identifying novel biomarkers and biology of early-stage heart failure using non-invasive, circulating biospecimens would aid in the development of advanced HF prevention strategies and help reduce disease burden. Leveraging cutting-edge machine learning methodologies would contribute to knowledge of techniques that optimize identification of biomarkers and biology broadly across cardiometabolic diseases.

PI_NAMEs: KOTTILIL, KALYANI  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adult;Advanced Development;Affect;American Heart Association;Attention;biobank;Biological;Biological Markers;Biology;biomarker identification;burden of illness;Calibration;candidate identification;candidate marker;Cardiac;cardiac magnetic resonance imaging;Cardiometabolic Disease;cardiometabolism;career;Cessation of life;Classification;Clinical;clinical biomarkers;Clinical Data;clinical imaging;clinically relevant;cohort;Communities;Complex;computable phenotypes;Computational Biology;Data;data integration;Data Set;deep learning model;deep neural network;demographics;Development;Diagnostic tests;Discrimination;Disease;early detection biomarkers;Early Diagnosis;Early identification;Electronic Health Record;Etiology;Fellowship;Functional disorder;Goals;Guidelines;Heart Diseases;Heart failure;Heterogeneity;Hospitalization;Hypertension;Image;improved;Individual;Inflammatory;Knowledge;large datasets;large scale data;learning strategy;Link;Machine Learning;machine learning method;Measures;Mendelian randomization;metabolomics;Methods;Modeling;Molecular;molecular marker;Molecular Profiling;Morbidity - disease rate;mortality;multimodal data;Multiomic Data;multiple omics;Myocarditis;neural network;neural network architecture;novel;novel diagnostics;novel marker;Obesity;Outcome;Participant;Pathway Analysis;Pathway interactions;Performance;Phenotype;Plasma;Plasma Proteins;Population;population based;pre-doctoral;predictive modeling;Prevention strategy;preventive intervention;Preventive therapy;prognostic;prognostic value;progression marker;Proteins;Proteomics;Public Health;Reproducibility;Research;Risk;Risk Factors;Sampling;Scientist;skills;Staging;structural heart disease;Structure;supervised learning;Symptoms;Techniques;Testing;Time;Training;Translational Research;United States;Work

PROJECT_TITLE: Integrative 'omics for biomarkers and biology of early-stage heart failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Hearing Loss;Neurosciences;Rehabilitation

PHR: The proposed research applies computational models of the human auditory system to better understand how listeners can detect sounds of interest against a background of competing sounds, such as a target talker speaking in a noisy room. The proposed models can simulate the effects of hearing loss and will be used to investigate how hearing loss at the peripheral level impacts neural coding of sound at higher levels of the auditory system, such as the inferior colliculus in the auditory midbrain. The results of this research will inform strategies to ameliorate perceptual changes associated with hearing loss in next-generation hearing aids and cochlear implants.

PI_NAMEs: GUEST, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Affect;Algorithms;Animal Model;Auditory;auditory processing;Auditory system;behavior measurement;behavior prediction;Behavioral;behavioral response;Binaural;Cell Nucleus;Cochlea;Cochlear Implants;Cochlear nucleus;Code;Complex;Computer Models;Cues;Data;Detection;Development;Discrimination;Efferent Pathways;flexibility;Goals;Hearing Aids;hearing impairment;Human;improved;Individual;Inferior Colliculus;interest;Investigation;Laboratories;Lead;Link;Masks;Measurement;Medial;Midbrain structure;Modality;Modeling;neural;Neurons;next generation;normal hearing;novel strategies;Outcome;Perception;Performance;Peripheral;Phase;Physiological;Physiology;Play;prediction algorithm;Process;Psychophysics;Regulation;Research;response;Role;Sensorineural Hearing Loss;Shapes;signal processing;sound;Speech;Speech Intelligibility;Stimulus;System;Techniques;Testing;Time;Translating;trend

PROJECT_TITLE: Modeling the effects of binaural midbrain coding and efferent gain control on the perception of complex sounds


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: NARRATIVE Recent studies in mice suggest that specific types of retinal ganglion cells, the neurons that degenerate in glaucoma, are more susceptible to injury. However, translating these findings to the human condition is not straightforward since the mouse and human eye differ in several major ways, including the ocular structures and types of retinal ganglion cells found in the two species. Here we propose a detailed multi-modal assessment of the mechanisms underlying ganglion cell susceptibility in a highly clinically relevant model of glaucoma, which will lead to improved understanding of the disease, novel targets for earlier diagnosis and treatment, and in turn, better options for glaucoma patients to preserve and potentially improve their vision.

PI_NAMEs: FORTUNE, BRAD ;OU, YVONNE  (contact);SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Cell Death;cell injury;Cell Therapy;cell type;Cells;Central Nervous System;clinical development;clinical translation;clinically relevant;Communities;Data;Dendrites;density;design;Development;Diagnostic;Disease;Early Diagnosis;Early treatment;Electrophysiology (science);Ensure;Exhibits;Experimental Models;Eye;fovea centralis;ganglion cell;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genetic Transcription;Glaucoma;Goals;Human;human disease;improved;in vivo;Individual;injured;Injury;Inner Plexiform Layer;innovation;insight;Intervention;Knowledge;Label;Laboratories;Learning;Macaca mulatta;macula;Maps;Modeling;Molecular;Molecular Analysis;Morphology;multi-electrode arrays;multimodality;Mus;Nerve Degeneration;neural circuit;Neuroanatomy;Neurons;neuroprotection;new therapeutic target;nonhuman primate;novel;novel diagnostics;novel strategies;novel therapeutics;Online Systems;patch sequencing;Pathologic;Patients;Pattern;Physiologic Intraocular Pressure;Physiological;Physiology;Predisposition;preservation;presynaptic;Primates;Protocols documentation;Reaction;repaired;Research Personnel;Resources;response to injury;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Rod;Rodent;Rodent Model;Shapes;sight restoration;Site;Specificity;Staging;Structure;Synapses;Testing;Therapeutic Intervention;Tissue-Specific Gene Expression;transcriptome;Translating;translation to humans;Translations;Vision;Vision research;Visual

PROJECT_TITLE: Retinal circuit disassembly in primate glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine

PHR: PROJECT NARRATIVE Neonatal, border zone cardiomyocytes can proliferate and survive post-injury in the mammalian heart, but this ability is rapidly lost as the cells mature with age. This proposal will investigate how border zone cardiomyocytes will respond to the loss of SPRR1A following cardiac injury in regenerative and non-regenerative neonatal hearts, and whether this will alter their proliferative capacity and their survivability. This work will highlight differences between the older, non-regenerative cardiomyocytes compared to the proliferative, neonatal cells, and these findings will improve our understanding on how to enhance cardiomyocyte survival in non-regenerative injury settings, such as myocardial infarction in patients.

PI_NAMEs: ZUPPO, DANIEL ANTHONY (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Adult;Age;Apical;Apoptosis;Apoptosis Inhibitor;Area;Binding;BIR Domain;Birth;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardioprotection;Cell Death;Cell Proliferation;Cell Survival;Cells;Cessation of life;Cicatrix;Complex;cytokine;Data;design;DNA cassette;Echocardiography;Excision;Exposure to;Fibrosis;Flow Cytometry;Frameshift Mutation;Heart;Heart failure;heart function;Heart Injuries;improved;Inflammation;Inflammatory;Injury;insight;Ischemia;Knock-in;Knock-out;Knockout Mice;Label;Left ventricular structure;Life;Mediating;Modeling;Mus;mutant;Myocardial Infarction;Myocardium;Necrosis;Neonatal;neonatal mice;neonate;novel;Open Reading Frames;overexpression;Pathologic;Pathway interactions;Patients;Phenotype;Physiology;Population;postmitotic;postnatal;Predisposition;prevent;Process;programs;Proliferating;proline-rich proteins;Proteins;Recovery;recruit;regenerative;Regenerative capacity;Reporter;Resolution;response;RIPK1 gene;Risk;Role;SPRR1A;targeted treatment;Testing;Time;tissue regeneration;Tissue-Specific Gene Expression;TNF gene;TNFRSF1A gene;TRAF2 gene;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Ventricular;Work

PROJECT_TITLE: Investigating the role of SPRR1A in border zone cardiomyocytes during neonatal cardiac repair


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Understanding the complex gene regulatory network controlling axon growth is a critical step to meet the challenge of poor axon regeneration in the central nervous system. The proposed study will combine RNA-seq and ATAC-seq in purified retinal ganglion cells at various developmental stages and use advanced integrative multi-omics analysis to identify core transcription factors regulating axon growth during retinal ganglion cell development, and functionally test the identified transcription factors in optic nerve regeneration model. The study will not only provide a comprehensive view of the transcriptional regulatory network that governs neuronal axon growth, but also reveal novel therapeutic targets for glaucoma and other neural injuries and neurodegenerative diseases.

PI_NAMEs: WANG, XUEWEI  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: ATAC-seq;Axon;axon growth;axon injury;axon regeneration;Binding;Bioinformatics;Cell Death Induction;Cell Survival;Cells;Central Nervous System;Chromatin;Collaborations;Communities;Complex;CRISPR/Cas technology;Cytoskeleton;Data;Data Set;deep sequencing;Development;differential expression;Dissociation;epigenome;experimental study;Frequencies;Gene Expression;gene regulatory network;Genes;genetic manipulation;Glaucoma;Goals;Growth Cones;improved;in vivo regeneration;Injury;interest;intravitreal injection;knock-down;knockout gene;Libraries;loss of function;Mediating;Mentors;Minor;Molecular;Multiomic Data;multiple omics;Mus;Natural regeneration;Nerve Crush;nerve injury;Nervous System;Neurodegenerative Disorders;neurogenesis;neuron development;Neurons;new therapeutic target;non-muscle myosin;Nonmuscle Myosin Type IIA;novel;Optic Nerve;optic nerve regeneration;Patients;Pattern;Phase;Play;Population;Preparation;Process;programs;Protocols documentation;Recovery of Function;regeneration model;Regulation;Research;response;Retina;Retinal Ganglion Cells;Role;screening;Series;Shapes;single-cell RNA sequencing;spatiotemporal;Spinal cord injury;Spinal Ganglia;Suspensions;Testing;Time;transcription factor;transcription regulatory network;transcriptome;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;Visual System

PROJECT_TITLE: Deciphering the Transcriptional Regulatory Network Controlling RGC Axon Growth to Promote RGC Axon Regeneration and Cell Survival after Axonal Injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: This project will provide knowledge that will aid in the improvement of public health measures and oversight related to potential pandemic pathogen research and dual use research of concern, and will also provide knowledge that can improve the formulation of new public health policies and regulations in the future.

PI_NAMEs: GILLUM, DAVID ;VOGEL, KATHLEEN  (contact)

PROJECT_TERMS: Academia;Area;Biological;Biological Sciences;biosecurity;Caring;citizen science;Data Collection;Educational workshop;Formulation;Future;future implementation;Government;Health Policy;Human Resources;improved;Individual;Industry;Institution;Institutional Policy;Interview;Knowledge;Measures;Methods;pathogen;pathogens of pandemic potential;Policies;Public Health;Recommendation;Regulation;Research;Research Personnel;Safety;Surveys;United States;Work

PROJECT_TITLE: SOS:BIO - Assessing U.S. Biosafety and Biosecurity Compliance for Potential Pandemic Pathogen Research and Dual Use Research of Concern

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 GDB-T (SP)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Age, disease, and menopause cause osteoporosis, which predisposes to bone fractures and decreased quality of life. Identifying the mechanisms by which mice acquire striking high bone mass can be used to identify novel therapeutic targets to promote bone anabolism in such diseases.

PI_NAMEs: GENETOS, DAMIAN C;YELLOWLEY-GENETOS, CLARE E (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Age;Aging;aging population;Anabolism;Attention;Attenuated;beta catenin;bone;bone cell;Bone Growth;bone health;bone loss;bone mass;Cell Physiology;Cell Survival;cell type;cost;Cre driver;Data;dentin matrix protein 1;Development;Disease;Down-Regulation;Estrogens;Fracture;Gene Targeting;Genes;Genetic;Genetic Epistasis;Genetic Transcription;Goals;HIF1A gene;Human;Hypoxia;Hypoxia Inducible Factor;improved;Incidence;Individual;LoxP-flanked allele;Measures;Mediating;Medical;Menopause;Molecular;Motivation;mouse model;Mus;Mutation;new therapeutic target;normoxia;novel;Osteoblasts;Osteocytes;Osteoporosis;osteoporosis with pathological fracture;osteoprogenitor cell;Ovariectomy;Pathway interactions;pharmacologic;Phenotype;prevent;Property;Protein Isoforms;Publishing;Quality of life;receptor;Reporting;Resistance;response;restoration;Rodent;Role;Signal Pathway;Signal Transduction;skeletal;Skeletal Development;Skeleton;socioeconomics;Specificity;Testing;Tumor Suppressor Proteins;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Wild Type Mouse;WNT Signaling Pathway;Work

PROJECT_TITLE: HIFs in osteocytes

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Inflammatory bowel diseases are complex disorders that represent a significant public health challenge. Tuft cells are a specialized cells that have recently been shown to amplify specific immune responses in the intestine. The goals of this proposal are to understand regulation of tuft cells in order to guide new therapeutic approaches to improve intestinal health and prevent disease.

PI_NAMEs: ALENGHAT, THERESA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: active control;adaptive immune response;Animals;Biology;Butyrates;Calibration;Cell Count;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;Cellular biology;Chromatin;commensal bacteria;commensal microbes;Complex;Crohn's disease;Data;Development;Disease;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;gain of function;Genetic;Genetic Transcription;Gnotobiotic;Goals;gut inflammation;gut microbiota;HDAC3 gene;Health;Histone Deacetylase Inhibitor;histone modification;Homeostasis;host microbiota;Human;Immune;Immune response;Immunity;improved;in vivo;Inflammation;Inflammatory Bowel Diseases;Innate Immune Response;Inositol Phosphates;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Link;loss of function;Mediating;microbial;microbiota;microbiota metabolites;Modeling;mouse model;Mus;novel;novel therapeutic intervention;nutrient absorption;Organoids;Pathogenesis;Pathologic;Pathway interactions;Patients;personalized approach;Play;Predisposition;prevent;Public Health;Publishing;Regulation;response;Role;sensor;Severities;Signal Transduction;Specialized Epithelial Cell;stem;stem cell differentiation;stem cells;Stimulus;Testing;tool;Transgenic Organisms;Ulcerative Colitis;villin;Work

PROJECT_TITLE: Epigenetic regulation of intestinal tuft cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Although both men and women are affected by alcohol use disorder (AUD), women often progress through AUD disease milestones faster and experience more severe health consequences than men; however, little is known about the synaptic and molecular mechanism driving these sex-differences. The sexually dimorphic prefrontal cortex (PFC) integrates excitatory glutamatergic inputs from subcortical structures to modulate cortical excitation, yet the mechanism by which ethanol alters these inputs remains unclear. This proposal seeks to investigate how ethanol alters glutamatergic strength and plasticity at discrete excitatory inputs to the PFC in female and male mice.

PI_NAMEs: FABIAN, CARLY B (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Affect;Age;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol research;alcohol response;alcohol reward;alcohol seeking behavior;alcohol use disorder;Amygdaloid structure;Animals;Automobile Driving;Behavior;binge drinking;Brain;Brain region;Cell Physiology;Cells;Chronic;Clinical;clinical development;CNR1 gene;Cognition;Data;designer receptors exclusively activated by designer drugs;Development;Disease;drinking;drinking behavior;Electrophysiology (science);Elements;Endocannabinoids;Ethanol;experience;experimental study;Female;Frequencies;Genetic;Glutamates;GRM5 gene;Health;Human;improved;inhibitory neuron;Injections;Interneurons;Knock-out;Knowledge;Learning;Link;male;Measures;Medial;Mediating;Membrane;men;Metabotropic Glutamate Receptors;Molecular;Mus;neural circuit;novel;Opsin;Optics;optogenetics;Parvalbumins;patch clamp;Persons;Pharmacology;Physiologic pulse;Physiology;pre-clinical research;Prefrontal Cortex;Publishing;receptor;receptor function;Receptor Signaling;Research Personnel;Rodent;Rodent Model;Role;Schedule;sex;Sex Differences;sexual dimorphism;side effect;Slice;Source;Structure;success;Synapses;Synaptic plasticity;Synaptic Transmission;Technical Expertise;Techniques;Testing;Thalamic structure;Therapeutic Intervention;therapeutic target;tool;Transgenic Organisms;transmission process;United States;Viral;Woman;Work

PROJECT_TITLE: Input specific adaptations to glutamatergic strength and plasticity on PFC PV-INs following ethanol drinking

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Genetics;Nutrition;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: In this project, we will use both gene- and metabolite-centered approaches to study metabolic perturbations in C. elegans with a focus on homologs of genes involved in inborn errors of metabolism in humans. We will combine computational and experimental methods to, broadly and deeply, determine how changes in genotype, nutrition, and the microbiota influence such perturbations.

PI_NAMEs: WALHOUT, A. J. MARIAN  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Age of Onset;Amino Acids;Animal Feed;Animals;Bacteria;Biological Models;Biological Process;Biomass;Caenorhabditis elegans;Cell Physiology;Complex;Computer Models;Defect;Development;Diabetes Mellitus;Diet;Disease;Drug Metabolic Detoxication;Economics;Environment;Environmental Risk Factor;Enzymes;Ethics;Eukaryota;experimental study;Fertility;Foundations;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Diseases;Genetic Screening;Genotype;Goals;Health;Heart;Homologous Gene;Human;Inborn Errors of Metabolism;Individual;insight;Life Style;Malignant Neoplasms;Mendelian disorder;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;metabolomics;Methods;microbiota;model organism;Modeling;molecular phenotype;Morbidity - disease rate;mutant;Mutation;Nematoda;novel;nutrition;Nutritional;Obesity;organic acid;Organism;Orthologous Gene;Pathway interactions;Penetrance;Pharmaceutical Preparations;Phenotype;Physiological;Physiological Processes;Physiology;Poison;Reaction;response;Severity of illness;Standardization;Supplementation;System;Therapeutic;Toxic effect;transcriptomics;Vitamin B 12 Deficiency;Work;wound healing

PROJECT_TITLE: C. elegans models of metabolism in health and disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN PSYCHIATRIC ASSOCIATION

ORG_STATE: DC

PHR: Project Narrative Increasing the provision of culturally competent mental health care can improve patient engagement and reduce disparities among medically underserved communities. It is, therefore, imperative that mental health practitioners are both clinically and culturally competent.

PI_NAMEs: JAMES, REGINA  (contact)

PROGRAM_OFFICER_NAME: MUELLER, NORA

PROJECT_TITLE: Improving Cultural Competency Across the Mental Healthcare Delivery Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-T (01)]


NIH_SPENDING_CATS: Aging;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: NARRATIVE The work proposed in this grant will advance our understanding of the effects of an FDA approved drug, rapamycin, which has significant benefit in preventing or reversing age-related dysfunction. The results are critical to the safe use of this drug to prevent multiple diseases such as Alzheimer's disease, cardiac failure, and loss of immune function in the elderly.

PI_NAMEs: SELL, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: adult stem cell;age related;Alzheimer's Disease;Cell Aging;Cells;clinical development;Data;Development;Disease;Drug usage;Elderly;extend lifespan;FDA approved;FRAP1 gene;Functional disorder;Goals;Grant;H19 gene;healthy aging;Heart failure;immune function;improved;individual response;Intervention;Laboratories;late life;Longevity;Maintenance;Monitor;mTOR inhibition;mTOR Inhibitor;novel;novel marker;Pathway interactions;Pharmaceutical Preparations;Play;pluripotency;prevent;programs;Research;response;Role;senescence;Sirolimus;Somatic Cell;stem cell population;Tissues;Untranslated RNA;Work

PROJECT_TITLE: Novel longevity enhancing pathways regulated by mTOR

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  The proposed study seeks to use multiple state-of-the–art molecular and cellular profiling platforms to construct a three-dimensional spatially resolved Ovarian Cancer Atlas using treatment naïve formalin fixed paraffin embedded (FFPE) ovarian tumor tissue samples obtained from the primary ovarian site and metastatic sites in racially diverse patients who are diagnosed with chemo-refractory or chemo-sensitive advanced high- grade serous ovarian cancer (HGSOC). We expect that the results will be used by academic researchers, clinical researchers and industry partners to improve our understanding of the molecular basis of the disease and better strategize disease management of patients. In addition, the results of this study would have the potential leading to the development of clinical trials testing novel agents against new molecular targets.

PI_NAMEs: BIRRER, MICHAEL ;FERRI-BORGOGNO, SAMMY ;MOK, SAMUEL C (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant;Adjuvant Chemotherapy;Algorithms;Anatomy;anti-cancer research;Arkansas;Atlases;Bioinformatics;Biological Specimen database;biomarker identification;Cancer Biology;cancer cell;Cancer Center;Cancer Etiology;Cancer Patient;cancer therapy;Cell Communication;cell type;Cells;Chemoresistance;chemotherapy;Cisplatin;Clinical;Clinical Data;clinical development;Clinical Management;Clinical Trials;cohort;computerized data processing;Data;Data Set;data warehouse;Database Management Systems;Databases;Development;Diagnosis;Dimensions;Disease;Disease Management;Disease stratification;Dissociation;Ecosystem;Ensure;Epithelium;experience;Formalin;Freezing;genetic signature;Geography;Goals;high dimensionality;Histologic;Human;Image;Immune;immune cell infiltrate;immune function;Immunofluorescence Immunologic;improved;industry partner;Infrastructure;insight;Inter-tumoral heterogeneity;International;Link;Literature;Location;lymph nodes;Malignant neoplasm of ovary;Malignant Neoplasms;malignant phenotype;Maps;mass spectrometric imaging;Mass Spectrum Analysis;metabolomics;Metadata;Modeling;Molecular;Molecular Target;multidisciplinary;multiple omics;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;Omentum;operation;Operative Surgical Procedures;Organ;Outcome;Ovarian;ovarian neoplasm;Ovary;Paraffin Embedding;Pathway interactions;Patient-Focused Outcomes;Patients;Pelvis;Peritoneal;Phenotype;Platinum;Prevention strategy;Procedures;Process;Prognosis;prognostic significance;prospective;racial diversity;reconstruction;Refractory;Refractory Disease;repository;Research;Research Personnel;Resistance;Resolution;response;Sampling;Serous;Signal Transduction;single-cell RNA sequencing;Site;Specificity;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard of care;Stromal Cells;Survival Rate;taxane;Testing;The Cancer Genome Atlas;therapy resistant;three-dimensional visualization;Tissue Embedding;tissue preparation;Tissue Sample;Tissues;Toxic effect;trafficking;transcriptomic profiling;Treatment Efficacy;Treatment Protocols;treatment response;tumor;Tumor Debulking;tumor heterogeneity;tumor microenvironment;Tumor Tissue;United States;Universities;virtual;White Women;Women's mortality

PROJECT_TITLE: 3D Spatial Multi-Omics Profiling of Ovarian Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M2)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Nutrition

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Staphylococcus aureus is a Gram-positive pathogen that relies on nutrient metals to respond to stress and cause infections. The proposed research will define the importance of zinc during S. aureus pathogenesis by determining the function of two putative metallochaperones CrzA and ZigA that we hypothesize bind and activate zinc-dependent S. aureus proteins implicated in DNA maintenance and DNA damage repair. The proposed work will establish the importance of CrzA- and ZigA-dependent metal allocation during the pathogenesis of infection and establish the regulation of DNA repair as a target for the development of new anti-microbial agents.

PI_NAMEs: ENRIQUEZ, KYLE T (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Affinity;anti-microbial drug;antimicrobial;antimicrobial resistant infection;ATP phosphohydrolase;Bacillus subtilis;Bacteria;Base Excision Repairs;Binding;Biochemical;Biological Assay;Bone Marrow;Bypass;Cell Physiology;Cessation of life;Chromatography;Client;clinical practice;Co-Immunoprecipitations;cofactor;Copper;Country;Data;Dependence;Development;Diet;Disease;DNA;DNA Damage;DNA Maintenance;DNA Repair;Enzymes;Escherichia coli;experimental study;Exposure to;Family;Genes;Genetic;Genomics;Genus staphylococcus;Gram-Positive Bacteria;Growth;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homeostasis;host colonization;Host Defense;Human;Hybrids;In Vitro;in vivo;Income;Inductively Coupled Plasma Mass Spectrometry;Infection;Integration Host Factors;Ions;Iron;Leukocyte L1 Antigen Complex;Libraries;Macrophage;Manganese;Measures;Mediator;Metalloproteins;Metals;Microbe;Microbiological Techniques;Modeling;mortality;Mus;Mutagenesis;mutant;Names;Nutrient;Nutrient availability;Nutritional Immunity;opportunistic pathogen;Organ;Orthologous Gene;pathogen;Pathogenesis;Phenotype;Play;prevent;Process;Protein Binding Domain;Proteins;Pseudomonas aeruginosa;Public Health;Regulation;Research;response;Role;S100 Proteins;Site;Staphylococcus aureus;Staphylococcus aureus infection;Starvation;Stress;Testing;Therapeutic;Transcription Repressor;Transition Elements;Vertebrates;Work;Yeasts;Zinc;zinc-binding protein

PROJECT_TITLE: S. aureus COG0523s as bacterial zinc metallochaperones critical to pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Donor organ shortage in kidney transplantation can be greatly mitigated by effective control of early alloimmunity and late organ fibrosis. Our preliminary studies suggest that recipient monocytes and macrophages play critical roles along the temporal line of this process. The overall goal of this proposal is to identify novel time-specific and pathway-specific targets for modulating recipient monocyte and macrophage functions post-kidney transplant, and ultimately pave the road for future designs of therapeutics for enhancing long-term kidney allograft survival.

PI_NAMEs: LUO, XUNRONG  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute;Allogenic;allograft inflammatory factor-1;Allografting;Anastomosis - action;Antigen-Presenting Cells;CCL8 gene;CCR8 gene;Cell Line;Cell Surface Receptors;Cells;Characteristics;Chronic;Chronic rejection of renal transplant;Circulation;Clinical;design;End stage renal failure;Environment;Evolution;experience;extracellular;Extravasation;Fibroblasts;Fibrosis;functional outcomes;Future;Goals;graft failure;Homeostasis;Human;Human Cell Line;Immune;Immunity;Immunobiology;Immunologics;Infiltration;Inflammatory;Injury;Injury to Kidney;Intercept;Ischemia;isoimmunity;Kidney;kidney allograft;kidney fibrosis;Kidney Transplantation;Macrophage;Measurement;Mediating;Modeling;monocyte;mouse model;Mus;novel;Organ;Organ Donor;Organ Transplantation;Outcome;Pathway interactions;Phenotype;Play;post-transplant;prevent;Process;Proteins;Receptor Protein-Tyrosine Kinases;Renal function;renal ischemia;Research Personnel;response;response to injury;retransplantation;Role;Signal Transduction;Smooth Muscle Myocytes;targeted treatment;Testing;Therapeutic;Time;timeline;Tissues;transplant model;Transplant Recipients;Transplantation;Vascular Diseases;Vascular Smooth Muscle

PROJECT_TITLE: Monocyte and Macrophage Functional Evolution in Kidney Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-S (02)]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Vaccine Related;Women's Health Research

PHR: Project Narrative Vulvovaginal candidiasis (VVC) is a prevalent infection affecting millions of women around the world. This project will reveal critical host factors required for protection against VVC in the vaginal mucosa, an understudied site of tissue-specific immune responses. Our work could lead to improved vaccine and therapeutic design for vaginal fungal infections.

PI_NAMEs: COOK, MELISSA ERIN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;anti-fungal agents;Architecture;Atopobium vaginae;Automobile Driving;Candida albicans;Candidiasis;Cell Line;cell type;Cells;Clinical;commensal microbes;comparative;Complex;cost;Cutaneous;cytokine;Cytokine Signaling;Cytoprotection;Data;Dermal;design;Disease;Environment;Epithelial Cells;Estrogens;Estrus;Event;Exhibits;experience;Family member;FDA approved;female reproductive tract;Flow Cytometry;fungus;Gene Activation;Gene Deletion;Genetic Transcription;global health;Health;High Prevalence;Homeostasis;Hormonal;Host Defense;Human;IL17 gene;Immune;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunopathology;immunoregulation;Impairment;improved;Individual;Infection;Integration Host Factors;interleukin-22;Knowledge;Mediating;microbiota;Modality;Modeling;Molecular;mortality;mouse model;Mus;Mycoses;Oral;Oral candidiasis;Organ;Organism;pathogenic fungus;Pathogenicity;Pathology;Persons;Physiology;Predisposition;Premenopause;Prevalence;Production;protective effect;Quality of life;receptor;Recurrence;recurrent infection;Regulation;response;Role;Signal Transduction;single-cell RNA sequencing;Site;System;Testing;Therapeutic;Tissues;transcription factor;Vaccine Design;Vaccines;Vagina;vaginal infection;vaginal mucosa;Vulvovaginal Candidiasis;Woman;Work

PROJECT_TITLE: Anti-fungal immune responses in the female reproductive tract

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: TUSCALOOSA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PI_NAMEs: MCMANUS, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: CHIOU, SHARON

PROJECT_TITLE: K01 Mentored Research Scientist Development Award