NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Immunotherapy;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Neurocysticercosis (NCC), the infection of the central nervous system (CNS) caused by the larvae  of Taenia solium, the pork tapeworm, is identified as the most common cause of  acquired epilepsy worldwide. Larvae encyst in the brain and other tissue and survive by   evading the host´s immune response. A better knowledge of the immunomodulation by the parasite  should allow us to understand its survival mechanisms and to improve and renew therapeutic  approaches. We propose to take advantage of a new in vitro model of development of Taenia  solium embryos developed by our group that allows us to determine stage-specific  differences in antigen expression to identify immunomodulatory molecules used by  the parasite to survive evading the host´s immune response, with a focus in the recently  described TGF-β mimic molecules shown to play a significant role in parasite immunomodulation

PI_NAMEs: VERASTEGUI, MANUELA RENEE (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired epilepsy;Address;Alkaline Phosphatase;angiogenesis;Anions;Anti-Inflammatory Agents;Antigens;astrogliosis;Binding;Biological Assay;blood-brain barrier permeabilization;Brain;candidate identification;CD3 Antigens;Cell Line;Cells;Central Nervous System Infections;Cestoda;Chronic;Clinical;Coupled;Cyst;cytokine;Data Set;Developing Countries;Development;Disease;effective therapy;Elements;Embryo;fast protein liquid chromatography;Fibrosis;FOXP3 gene;Gel Chromatography;Genes;Genome;Growth;Helminths;Homologous Gene;Immune response;Immunomodulators;immunoregulation;Immunotherapy;improved;In Vitro;in vitro Assay;in vitro Model;Infection;Inflammatory;Inflammatory Response;Interleukin-2;Knowledge;Laboratories;Larva;Ligands;Mass Spectrum Analysis;member;model development;Neurocysticercosis;neuroinflammation;Neurologic;novel;overexpression;Parasites;Pathologic;Pathology;Pathway interactions;Patients;Pharmacologic Substance;Play;prevent;protein expression;Proteins;Proteomics;Protozoa;Recombinants;Regulation;Regulatory T-Lymphocyte;Reporter;Reporting;Resources;Role;secretory protein;Severity of illness;Signal Transduction;Symptoms;Taenia solium;Testing;Therapeutic;Tissues;transcription factor;transcriptome;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors

PROJECT_TITLE: Understanding Immune Modulation in Taenia solium neurocysticercosis by using a novel postoncosphere in vitro model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: TORRANCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative The proposed study will investigate how a protein called ALKBH4 controls a specific chemical modification, m6A, on mRNAs, which is known to be essential for the production of good quality of sperm, male fertility and long-term offspring health. Results to be obtained will have a huge impact on human reproductive health.

PI_NAMEs: YAN, WEI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: 3' Untranslated Regions;Ablation;Affect;alpha Actin;Alternative Splicing;Animal Model;Attention;Biochemical;Biological Assay;Cell Nucleus;cell type;Cells;Chemicals;Code;cofactor;Comparative Study;Complex;conditional knockout;crosslinking and immunoprecipitation sequencing;Cytoplasm;Data;Development;diagnostic value;epitranscriptomics;Gene Expression;Genes;Germ Cells;Health;Homologous Gene;Human;In Vitro;in vitro Assay;in vivo;in vivo Model;Initiator Codon;insight;interest;Investigation;Knockout Mice;Knowledge;male;Male Contraceptive Agents;male fertility;Male Infertility;Maps;Messenger RNA;Modification;Molecular;mRNA Precursor;Mus;novel;novel marker;offspring;Physiological;Play;Production;protein complex;Proteins;Publishing;Reader;Regulation;Reporting;Reproductive Health;RNA;RNA Splicing;Role;Series;Signal Transduction;Site;Somatic Cell;sperm quality;Spermatids;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Terminator Codon;Testing;Testis;therapeutic target;Time;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Epitranscriptomic regulation of spermatogenesis and male fertility

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Splicing of gene transcripts is an essential process in human cells and frequently dysregulated in disease. Despite progress, the molecular-level mechanisms of splice site identification are incompletely understood. We seek to understand how the splicing machinery identifies gene transcripts for processing into legible RNA messages, thereby providing context for personalized medicines to treat patients with dysfunctional splicing.

PI_NAMEs: KIELKOPF, CLARA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;3-Dimensional;Address;Affinity;Alternative Splicing;Amino Acid Motifs;Binding;Binding Sites;Biochemical;Biological Assay;biophysical techniques;C-terminal;Calorimetry;cancer recurrence;Capsicum;Categories;Cells;Co-Immunoprecipitations;Collaborations;Complex;Coupling;Cryoelectron Microscopy;Dinucleoside Phosphates;Disease;Dissociation;Ensure;Eukaryota;Event;experimental study;Fluorescence;Fluorescence Anisotropy;Fluorescence Resonance Energy Transfer;Foundations;Functional disorder;Gene Expression;Genes;Goals;Grant;Human;human disease;Intellectual functioning disability;Laboratories;Ligands;Malignant Neoplasms;Methods;Molecular;Molecular Conformation;molecular recognition;mRNA Precursor;Mutation;Nature;Neurodevelopmental Disorder;Nuclear;Nucleotides;Patients;personalized medicine;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Process;Proline;Protein Dephosphorylation;Protein phosphatase;Proteins;recruit;Recurrence;Resolution;response;RNA;RNA Binding;RNA Recognition Motif;RNA Splice Sites;RNA Splicing;RNA-Binding Proteins;Role;Sequence Analysis;Series;SF1;Signal Transduction;single molecule;Site;Spliced Genes;Spliceosome Assembly Pathway;Spliceosomes;Structure;Syndrome;System;Testing;Threonine;Titrations;Transcript;transcriptome;U2 Small Nuclear Ribonucleoprotein;Work;X-Ray Crystallography;Zinc

PROJECT_TITLE: Molecular Recognition During Pre-mRNA Splicing

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our program prepares pre- and post-doctoral trainees to acquire advanced mental health services research skills to address challenges faced by the most vulnerable populations in our nation. Specifically, persons living with mental disorders who seek care at the intersection of multiple services sectors (e.g., specialty care, social services, schools) experience high needs for care, and are the least likely to secure needed services or to obtain high quality care. We are the only NIMH-funded T32 program located in a school of social work exclusively focusing on mental health services research. Since 1995, we have trained leaders in mental health services research and social work scholars in mental health. The overall mission of our program is for our trainees to acquire mental health services research knowledge and skills to meet the most pressing needs in the field of social work and to advance the public health significance and impact of NIMH-services research.

PI_NAMEs: CABASSA, LEOPOLDO J (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Health Services Research;Mental Health Services;Schools;Training Programs

PROJECT_TITLE: Brown School Training Program in Mental Health Services Research


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will investigate the long-term impacts of an unanticipated large-scale natural disaster on the human capital and wellbeing of exposed youth. Data will come from the Study of the Tsunami Aftermath and Recovery (STAR), a 15-year panel study of coastal communities, households, and individuals in Aceh and North Sumatra on the island of Sumatra in Indonesia, who were at risk of exposure to the 2004 Indian Ocean earthquake and tsunami, that is designed to leverage the natural experiment of the tsunami to study the causal effects of large-scale adverse events on a large sample of individuals that was representative of the pre- tsunami population. This project will also fully leverage all eight rounds of STAR panel data (one baseline and seven follow-up rounds) to closely trace out the trajectories of child outcomes in the initial and intermediate post-disaster periods, as well as continue to follow those outcomes into the longer-term, which will provide detailed insights into post-disaster resiliency and recovery and into the mechanisms underlying the long-term impacts of the disaster that studies with fewer survey rounds cannot observe.

PI_NAMEs: INGWERSEN, NICHOLAS S (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: acetone hydrazone;Address;Adolescence;Adult;Adverse event;Affect;Age;age difference;Age Years;Automobile Driving;Child;Childhood;childhood adversity;Cognition;Cognitive;cognitive performance;Communities;Country;Coupled;Data;design;Dimensions;disaster resilience;Disasters;Earthquakes;Education;emerging adult;Event;experience;Exposure to;Family;Family member;Female;Fertility;follow-up;Frequencies;Grain;Health;Health care facility;Heterogeneity;Household;human capital;Indian Ocean;Individual;Indonesia;Infrastructure;insight;Island;Life;male;Marriage;Measures;Mental Health;migration;Natural Disasters;Natural experiment;Outcome;Outcome Measure;Parents;Pathway interactions;Personal Satisfaction;physical conditioning;Population;post-traumatic stress;Poverty;Procedures;Process;Prospective Studies;reconstruction;Recovery;Research;resilience;Resources;Respondent;Risk;Sampling;Sampling Studies;Schools;socioeconomics;Specificity;Subgroup;Sumatra;Surveys;Time;Trauma;Tsunami;Variant;Work;Youth

PROJECT_TITLE: Long-term impacts on human capital of children exposed to a natural disaster

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The long-term goal of this research is to inform policies to reduce tobacco use and related disparities, as well as to inform policy efforts more broadly, particularly as timely issues, like firearm safety, nutrition policies, and COVID-19 mitigation measures, are increasingly subject to state preemption; this project will analyze whether—and to what extent—enactment or repeal of state preemption on local tobacco control (smoke-free air, advertising, licensure, youth access, and taxation) is associated with tobacco-related disparities. Guided by a socioecological perspective, our central hypothesis is that state preemption laws lead to disproportionately high tobacco use, secondhand smoke exposure, and retail (sales, retail density) in communities with more racial/ethnic minorities, of lower socioeconomic status, and/or in rural settings. This study will have high impact, as it will: 1) contribute novel data to the evidence base regarding state preemption impact on health outcomes/disparities and their potential mechanisms; 2) inform state and local policy efforts to reduce tobacco use and related disparities plaguing certain vulnerable populations; and 3) engage key tobacco control and policy experts to catalyze effective research translation and dissemination.

PI_NAMEs: BERG, CARLA J;YANG, Y. TONY  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Address;Adolescent;Adult;Advertisements;Advertising;Affect;Air;American;Attention;Categories;Classification;Code;Communities;Community Surveys;Consensus;County;COVID-19;Data;Databases;density;Disparity;Disparity population;Electronic cigarette;Empirical Research;environmental tobacco smoke exposure;ethnic minority;Ethnic Origin;evidence base;experience;Face;Firearms;Foundations;Funding;Geography;Goals;Health;health disparity;improved;indexing;Individual;Industry;information processing;Laws;Lead;Licensing;Licensure;Link;Literature;Location;low socioeconomic status;Measures;Minority Groups;multilevel analysis;National Health and Nutrition Examination Survey;National Health Interview Survey;non-smoker;novel;Nutrition Policy;Outcome;Outcome Measure;Persons;Policies;Population;preempt;Public Health;public policy on tobacco;Publishing;Race;racial minority;reduce tobacco use;Research;research data dissemination;Rights;Rural;rural dwellers;Rural Population;rural setting;Safety;Sales;Sampling;Smoke;smoke-free policy;smoking prevalence;sociodemographics;Socioeconomic Status;Source;State Government;Statutes and Laws;Subgroup;Surveys;System;Taxation;Taxes;Time;Tobacco;tobacco control;Tobacco Industry;tobacco products;Tobacco use;tool;Translational Research;Vulnerable Populations;Walking;Work;Youth

PROJECT_TITLE: Effects of State Preemption of Local Tobacco Control Legislation on Disparities in Tobacco Use, Exposure and Retail

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Allergic diseases such as asthma, sinus allergy, and food allergy are very common and effect over 20% of the population of the United States. This training grant will train physicians and PhD researchers to perform research on allergic patients to identify better ways of diagnosing and treating allergic diseases.

PI_NAMEs: BROIDE, DAVID H (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Training in Molecular and Cell Biology of Allergy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Narrative Reliable diagnosis of Parkinson’s disease is currently possible only at late stages of the disease, after hallmark symptoms such as movement dysfunction are evident. Accurate, early diagnosis is critical to pursuing differential prognostic and disease management approaches, and to assessing the efficacy of therapeutic interventions. We aim to develop a specific radioligand, MCL-524, to identify disease-specific changes to D2 expression and function as an early, quantifiable biomarker in prodromal PD; the results from this study will enable the development of MCL-524 towards clinical application in humans.

PI_NAMEs: SUBBURAJU, SIVAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affinity;Agonist;Animal Model;antagonist;Binding;Biological Markers;blood-brain barrier crossing;Brain imaging;Cells;Clinical;clinical application;clinical diagnosis;Corpus striatum structure;Data;density;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic tool;Disease;disease diagnosis;Disease Management;Disease Progression;Dopamine D2 Receptor;Dopamine Receptor;dopamine transporter;dopaminergic neuron;Early Diagnosis;Early treatment;Economic Burden;efficacy evaluation;Exclusion;Family;Female;Fluorine;Functional disorder;Goals;Human;Idiopathic Parkinson Disease;In Vitro;in vivo;Injections;Intervention;Intravenous;Ligands;male;Measures;median forebrain bundle;Metabolic;Modeling;Motor;Movement;nanomolar;Nerve Degeneration;Neurodegenerative Disorders;neuroprotection;new therapeutic target;nigrostriatal pathway;Oxidopamine;Parkinson Disease;pars compacta;Pathologic;Patients;Phase;Positron-Emission Tomography;preclinical evaluation;prognostic;Protocols documentation;Publishing;putamen;Quantitative Autoradiography;radioligand;Radiopharmaceuticals;radiotracer;Rattus;receptor;receptor binding;receptor expression;receptor function;research clinical testing;Safety;Saline;single photon emission computed tomography;Site;socioeconomics;Specificity;Structure;Substantia nigra structure;Symptomatic Parkinsonism;Symptoms;Tail;Therapeutic Intervention;Up-Regulation;Veins

PROJECT_TITLE: Preclinical evaluation of the D2 receptor agonist MCL-524 as diagnostic marker for presymptomatic Parkinson's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: ATLANTA

ORG_NAME: ADENOPAINT, LLC

ORG_STATE: GA

PHR: Project Narrative  Microvascular obstruction remains a significant barrier to optimize outcomes after PCI for myocardial infarction (MI), the leading cause of death in US. AdenoPaint has developed a transformative drug loaded guidewire platform (Adenowire) that allows for continuous elution of adenosine, a potent cardioprotective agent, throughout the procedure. The overall goal of this project is to advance the development of Adenowire to clinical trials to improve outcomes in MI patients.

PI_NAMEs: FORMAN, MERVYN B. (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Accreditation;Adenosine;Adhesions;Advanced Development;Affect;American;Animal Model;Area;Attenuated;biomaterial compatibility;Blood;Blood Platelets;Blood Vessels;Cardiotonic Agents;Cardiovascular Diseases;Cause of Death;Cessation of life;Chemistry;Classification;Clinical Research;Clinical Trials;commercialization;Complex;Coronary;Coronary Arteriosclerosis;Data;design;Development;Devices;Diffusion;Documentation;Drug Delivery Systems;Engineering;Evaluation;FDA approved;first-in-human;Funding;Goals;Good Manufacturing Process;Grant;Guidelines;Half-Life;Heart failure;Human;Hydrogels;hydrophilicity;improved outcome;In Vitro;innovation;Intellectual Property;Intervention;Intravenous;Laboratories;Laboratory Research;manufacture;Manufacturer;manufacturing scale-up;Marketing;Mechanics;Medical;Medical Device;member;Methods;mortality;Myocardial;Myocardial Infarction;novel;Nucleosides;Obstruction;Outcome;Outsourcing;Pathway interactions;Patients;percutaneous coronary intervention;Performance;Pharmaceutical Preparations;Phase;Practice Guidelines;preclinical evaluation;preclinical study;Procedures;programs;Quality Control;randomized trial;Regulatory Pathway;Research;research and development;Risk Factors;Safety;Secure;Seminal;Small Business Innovation Research Grant;Sterilization;supply chain;Surface;System;Technology;Testing;Therapeutic;tissue injury;vasoconstriction;Vasodilation;Vendor

PROJECT_TITLE: Novel Guidewire Design and Coating for Adenosine Delivery


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Loss of hand function following stroke is a major rehabilitation problem affecting hundreds of thousands of people per year in the United States. Developing rehabilitation interventions that are both effective and appropriate for a wide range of stroke survivors remains a major unmet clinical need. This research is an important step in developing an innovative therapy that combines noninvasive brain stimulation with muscle stimulation for improving recovery of hand function after stroke.

PI_NAMEs: CUNNINGHAM, DAVID ARTHUR (contact);KNUTSON, JAYME S.

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acceleration;Advanced Development;Affect;aged;Anodes;balance recovery;Bilateral;Blinded;Brain;Chronic;chronic stroke;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;constraint induced movement therapy;Contralateral;Cross-Over Studies;dexterity;disability;Dose;Electric Stimulation;Electric Stimulation Therapy;Electrodes;Extensor;Fingers;follow-up;FPS-FES Oncogene;functional electrical stimulation;functional improvement;Hand;Hand functions;hand rehabilitation;hemiparesis;Hemiplegia;Impairment;improved;improved outcome;Innovative Therapy;instrument;Intention;Intervention;Learning;Methods;Modality;Modeling;Motor;Motor Cortex;motor recovery;Movement;Muscle;neuromuscular stimulation;Neuronal Plasticity;Neurons;neurophysiology;noninvasive brain stimulation;novel;novel therapeutics;Occupational Therapy;Outcome;Output;Paresis;Participant;patient population;Patients;Peripheral Nerve Stimulation;Persons;post stroke;Randomized;Randomized, Controlled Trials;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;robot assistance;Stroke;stroke survivor;Surface;synergism;Testing;Therapeutic Effect;therapy development;Thumb structure;transcranial direct current stimulation;United States;Upper Extremity;upper limb hemiparesis;Work

PROJECT_TITLE: tDCS During Contralaterally Controlled FES for Upper Extremity Hemiplegia

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative More than 3 million Americans have a bleeding disorder that could be deadly without treatment, while conversely, around 900,000 Americans each year are affected by a blood clot, resulting in nearly 100,000 – 300,000 deaths. As many patients still suffer from bleeding and clotting disorders of unknown cause, this proposal will probe previously unexplored molecular mechanisms involved in the production and function of different forms of blood proteins that are constantly working together to prevent unnecessary bleeding and clotting throughout all stages of life. Furthering our understanding of these mechanisms and their dysregulation has important implications for improving the treatment of bleeding and clotting disorders.

PI_NAMEs: SIEBERT-MCKENZIE, AMY  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: 3' Splice Site;Adult;Affect;Alternative Splicing;American;Anticoagulants;Area;Basic Science;Binding;Biochemical;Biochemical Pathway;Biological;Biology;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Proteins;Blood Vessels;career;Cell Line;cell type;Cells;Cessation of life;Coagulation Process;Conserved Sequence;Coupled;Cues;Defect;defined contribution;Development;Disease;Elements;Embryo;Embryonic Development;Endothelium;Equilibrium;Event;Exons;factor V Leiden;Frequencies;Generations;Genes;Genotype;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;human disease;improved;in vivo;Individual;inhibitor;innovation;Life;life span;Messenger RNA;Microscopic;Molecular;mRNA Expression;mRNA Precursor;Mus;mutant mouse model;Myeloid Progenitor Cells;Pathologic;Patients;Perinatal;Perinatal mortality demographics;Phase;Phenotype;Physiological;Placenta;Plasma;Polyadenylation;Positioning Attribute;Pregnancy;prevent;Production;Protein Isoforms;Proteins;recruit;Regulation;Regulatory Element;Research;Research Personnel;RNA;RNA Splicing;Role;Signal Transduction;Site;skills;Source;Spontaneous abortion;Surface;Technical Expertise;Testing;TFPI;Thrombin;Thromboplastin;Thrombosis;Training;Transcript;Variant;Woman

PROJECT_TITLE: Pre-mRNA Processing and Function of Alternatively Spliced Isoforms of TFPI

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Primary Health Care;Sexually Transmitted Infections;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Adolescents are disproportionately affected by HIV and often access the emergency department (ED) as their only source of care. This multicenter, pragmatic trial seeks to adapt, refine, and test a previously developed tablet-based, broad scale gonorrhea and chlamydia screening intervention process to increase universally offered, opt-out HIV screening in the pediatric ED and use an innovative mHealth HIV pre-exposure prophylaxis (PrEP) navigation platform to identify and link at-risk youth to ongoing PrEP care. Results will contribute to the evidence base that informs the development of effective and sustainable HIV screening and prevention programs that can be successfully integrated into the clinical workflow of the ED.

PI_NAMEs: DOWSHEN, NADIA L;GOYAL, MONIKA KUMARI;REED, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;age group;AIDS prevention;Applied Research;Appointment;Awareness;Behavior;candidate identification;Caring;Centers for Disease Control and Prevention (U.S.);Chlamydia;Clinical;clinical decision support;clinical practice;Collaborations;Collection;computed tomography screening;computerized;Computers;cost effective;Country;Data;Data Reporting;design;Detection;Development;Diagnosis;digital health;Education;Effectiveness;Electronic Health Record;Electronics;Eligibility Determination;Emergency Care;Emergency department visit;Epidemic;evidence base;follow-up;Goals;Gonorrhea;Health;health care settings;Health Technology;Healthcare;high risk;high risk sexual behavior;HIV;HIV-infected adolescents;HIV/AIDS;Home;Hour;Human immunodeficiency virus test;implementation strategy;improved;Infection;innovation;insight;interest;Interruption;Intervention;Link;Literature;Location;Logistics;Measures;Medical;Methods;mHealth;novel;Patient Outcomes Assessments;Patients;pediatric emergency;Pediatric Hospitals;Persons;Policies;Population;pragmatic trial;pre-exposure prophylaxis;preference;prevent;Prevention;Prevention program;Prevention strategy;Preventive care;Preventive healthcare;Primary Care;primary care services;primary care setting;Process;Provider;provider adherence;Public Health;Recommendation;Research;response;Risk;screening;screening program;Series;seroconversion;Services;Sexual Health;Source;stem;Tablets;telehealth;Testing;Text Messaging;Time;treatment adherence;United States;uptake;Viral;Visit;Work;Youth

PROJECT_TITLE: Screen Smart: Using Digital Health to Improve HIV Screening and Prevention for Adolescents in the Emergency Department


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Accumulation of hyperphosphorylated tau in the brain is key to the development of Alzheimer’s disease, but the pathological details of this phenomenon are elusive. This project aims to establish a novel animal model to interrogate the mechanism of hyperphosphorylated tau-inflicted neurodegeneration. If successful, this project will support Alzheimer’s disease drug development.

PI_NAMEs: KUO, MIN-HAO  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: abeta accumulation;abnormally phosphorylated tau;Adult;Aftercare;age related;age related neurodegeneration;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;Amyloid beta-Protein;Animal Model;Animals;antagonist;Apolipoprotein E;Area;Behavior;Blood - brain barrier anatomy;blood damage;Brain;brain tissue;Categories;Clinical;Cognition;Complement;Defect;Dementia;Deposition;Development;Disease;Drosophila genus;Drosophila melanogaster;drug development;drug discovery;Drug Modelings;epidemiology study;expectation;Exposure to;feeding;fly;Food;Food Supplements;Foundations;Functional disorder;Future;Genes;Genetic;Genetic Techniques;Goals;gut-brain axis;Human;hyperphosphorylated tau;Impaired cognition;Injections;Knock-in;Locomotion;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurologic;neurological pathology;neurotoxic;novel;Organism;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Persons;Phosphorylation;Phosphotransferases;Play;Predisposing Factor;Prevention;Protein Isoforms;Proteins;Proteolysis;recruit;Reporting;Research;Risk Factors;Role;Sampling;Senile Plaques;Symptoms;synergism;System;tau mutation;tau Proteins;tau-1;Tauopathies;Therapeutic;tool;trait;transgene expression;Transgenic Animals;Transgenic Organisms;Translational Research;World Health Organization

PROJECT_TITLE: A novel non-transgenic fly model for tauopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Successful completion of the proposed studies will significantly advance our knowledge regarding TDP-43 mediated R-loop dynamics that govern transposon elements (TE) expression landscapes in AD and may identify key human TEs that promote AD pathogenesis, which will have a significant impact on identifying more effective therapeutic treatments that are urgently needed in AD. Given the increasingly documented TE dysregulation in AD, strategies and experimental tools generated by our studies can be readily applied to explore TE function in various neural cell types in healthy and diseased human brains far beyond this proposal, which is a critical prerequisite for developing novel diagnosis/prognosis biomarkers and therapeutics.

PI_NAMEs: JIN, PENG  (contact);YAO, BING

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;abeta accumulation;abeta oligomer;Affect;age related;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Astrocytes;Autopsy;Binding;Biological;Biological Models;Brain;Brain region;Cell Nucleus;Cell Separation;cell type;Cells;Central Nervous System;Chromatin;Clinical;clinical phenotype;clinically relevant;Cognition;Data;Development;Diagnosis;Disease;Disease Progression;DNA;DNA Binding;DNA Sequence;DNA Transposable Elements;DNA Transposons;DNA-Binding Proteins;effective intervention;Elements;Epigenetic Process;Event;familial Alzheimer disease;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic Transcription;genome integrity;Genome Stability;genome-wide;genome-wide analysis;Genomic Instability;Goals;Homeostasis;Human;human disease;Human Genome;human model;Hybrids;improved;induced pluripotent stem cell;insight;interest;knock-down;Knowledge;Language;Link;loss of function;Maintenance;mammalian genome;Mediating;Memory;Messenger RNA;Metabolism;Modeling;Molecular;molecular phenotype;Molecular Target;mouse model;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxicity;novel;Nuclear;nucleic acid structure;Organoids;Pathogenesis;Pathologic;Patients;Play;Prefrontal Cortex;Process;prognosis biomarker;Prosencephalon;protein aggregation;protein misfolding;protein TDP-43;Publications;Regulation;Reporting;RNA;RNA Binding;RNA-Binding Proteins;Role;Senile Plaques;Sorting;Structure;System;tau Proteins;technology platform;Testing;Therapeutic;therapeutically effective;tool;Transcriptional Regulation;transcriptome;Translating

PROJECT_TITLE: Elucidating the Roles of Transposable Elements in Alzheimer's and related dementias


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Patient Safety;Rehabilitation

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Patients with deep brain stimulation implants can highly benefit from magnetic resonance imaging (MRI) exams, but MRI is not accessible to these patients because of safety risks due to radiofrequency heating of implants. In this project we will develop novel MRI hardware and DBS lead management strategies that eliminate RF heating and bring high resolution MRI accessible to DBS patients.

PI_NAMEs: GOLESTANI RAD, LALEH  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Anatomy;Area;Brain;Cell Nucleus;Cephalic;Cerebrum;Characteristics;chronic pain;clinical application;Clinical Management;Clinical Trials;Cognition Disorders;Computer Assisted;Computer Models;Coupling;Deep Brain Stimulation;deep brain stimulation array;deep field survey;design;Development;Device Safety;Devices;Disease;electric field;Electrodes;Engineering;Epilepsy;Failure;Feasibility Studies;Fever;Friends;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Guidelines;Hand;Head;Heating;high resolution imaging;Image;Imaging Techniques;Implant;implantable device;implantation;Implanted Electrodes;improved;Individual;individual patient;Industry;innovation;instrumentation;Knowledge;Lead;lead optimization;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Mechanics;Methodology;millimeter;Modification;Monitor;Mood Disorders;Morphologic artifacts;Movement Disorders;neuroimaging;Neurophysiology - biologic function;neuroregulation;neurosurgery;Neurosurgical Procedures;next generation;novel;Operative Surgical Procedures;Parkinson Disease;Patients;Physiologic pulse;Pilot Projects;Positioning Attribute;Protocols documentation;radio frequency;Randomized;Reproducibility;Resolution;response;Risk;Rotation;Safety;safety assessment;Scientist;side effect;simulation;soft tissue;standard care;standard of care;structural imaging;Structure;success;Techniques;Technology;temporal measurement;Testing;Therapeutic;Tissues;transmission process;Variant;Visualization;Work

PROJECT_TITLE: Reconfigurable MRI technology for safe and high-resolution imaging of deep brain stimulation at 3T

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The goals of the Infectious Diseases Research Training Program at Yale are to train and develop the next generation of physician-investigators in infectious diseases research; graduates of this training program will contribute to basic, clinical and translational research that will facilitate the development of new preventative and therapeutic measures for infectious diseases.

PI_NAMEs: MEYER, JAIMIE ;SHAW, ALBERT C (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Training

PROJECT_TITLE: Training in Investigative Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The T32 postdoctoral training program in Medical Genetics at the Johns Hopkins University trains physicians and scientists in the application of genetic principles to understand the causes and mechanisms of inherited diseases in humans. Through mentored research training, T32 trainees acquire experiences and expertise in translating genetic information from bench to bedside with the primary goal of improving health outcomes in patients with genetic and genomic disorders.

PI_NAMEs: WANG, TAO  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Grant;Medical Genetics;Training

PROJECT_TITLE: Medical Genetics Training Grant


NIH_SPENDING_CATS: Aging;Genetics;Obesity

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Skeletal muscle is a critical organ towards whole body metabolic regulation. We have identified novel mechanisms by which cellular metabolism maintains the abundance of critical antioxidant defense enzymes in skeletal muscle. This proposal will explore the regulation of these critical cell proteins in skeletal muscle tissues and the applicability of our finding in age-related diseases.

PI_NAMEs: HAUS, JACOB M (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Acetylation;adduct;Adult;adult obesity;Advanced Glycosylation End Products;age-related disease;aging related;Alanine;Amino Acids;Antioxidants;Attenuated;attenuation;Carbon;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;Data;Deacetylase;Deacetylation;Drug Metabolic Detoxication;Enzymes;functional outcomes;gain of function;Gene Dosage;gene editing technology;Generations;genome editing;Glucose Intolerance;glucose metabolism;glycation;Health;healthspan;Heterozygote;Human;Impairment;in silico;in vitro Model;Inflammation;Inflammatory;inhibitor;Insulin Resistance;knock-down;Knock-out;Knowledge;Lactoylglutathione Lyase;life span;loss of function;Lysine;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;Modification;Muscle;Muscle Fibers;Muscle function;Mutagenesis;mutant;Mutate;NADH;nicotinamide phosphoribosyltransferase;nicotinamide-beta-riboside;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Obesity;obesogenic;Organ;Overnutrition;Oxidative Stress;Peptides;Phenotype;Phosphorylation;Phosphorylation Inhibition;Physiological;Polyubiquitination;Post-Translational Modification Site;Post-Translational Protein Processing;preservation;Process;Production;Proteins;Proteomics;Pyruvaldehyde;Reactive Oxygen Species;Regulation;Role;senescence;SIRT1 gene;Sirtuins;Skeletal Muscle;skeletal muscle metabolism;Stress;stressor;System;targeted treatment;therapeutic target;Thinness;Threonine;Tissues;translational model;Work;young adult

PROJECT_TITLE: Exploring regulatory mechanisms of glyoxalase-1

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Millions of adults have gained dental insurance since the implementation of the Affordable Care Act (ACA), however, despite significant health policy efforts to reduce disparities in oral health, utilization of dental services among vulnerable groups remains low. In this study, we will assess whether the availability of dental providers is a barrier to accessing dental care among low-income and minority adults. In addition, we will examine whether the extent of this problem will vary across states as a function of both Medicaid policies and neighborhood characteristics.

PI_NAMEs: ELANI, HAWAZIN W (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: access disparities;Adult;Affordable Care Act;American;Appointment;beneficiary;Characteristics;Child;Clinic;Data Collection;Dental;Dental Care;Dental Clinics;Dental Insurance;Dentists;design;Disadvantaged;Disparity;Disparity population;disparity reduction;Emergency department visit;Enabling Factors;ethnic minority;experience;experimental study;Face;geographic barrier;Goals;Health;health care model;health care service;health care service utilization;health disparity;Health Insurance;health literacy;Health Policy;Healthcare;improved;Insurance;Insurance Coverage;Low income;Low Income Population;Marketing;Measures;Medicaid;Minority;Minority Status;National Institute on Minority Health and Health Disparities;Neighborhoods;Oral health;Patients;Policies;Population;Predisposing Factor;Privatization;programs;Provider;racial minority;Racial Segregation;Research;Schedule;segregation;Services;socioeconomic disadvantage;structural determinants;Structural Racism;Testing;Time;Travel;uptake;Variant;Vulnerable Populations;Wait Time;Work

PROJECT_TITLE: Field Experiment to Assess the Impact of Medicaid on Disparities in Dental Care Utilization

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Sexually transmitted infections, including HIV, are major public health issues in the United States and globally. This training program, now in its 45th year, has trained 250 predoctoral students and postdoctoral fellows, including infectious disease physicians, in STD and HIV/AIDS research, 80% of whom have continued in academia, public health or government, or in other biomedical research venues. Continued support for this training program is requested.

PI_NAMEs: DOMBROWSKI, JULIA COOK (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Grant;Research Training

PROJECT_TITLE: STD and AIDS Research Training Grant

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: This T32 application outlines the plan for an education program entitled “Rochester Musculoskeletal (ROCMSK) Training Program”, which is based in the Center for Musculoskeletal Research at the University of Rochester Medical Center. ROCMSK is designed to provide interdisciplinary didactic and research training in musculoskeletal science with the aim of developing future generations of musculoskeletal scientists and leaders of innovations. This program will nurture the career development of energetic young musculoskeletal investigators with a goal of independent funding success to ensure continued future innovations in musculoskeletal research from basic science through clinical translation.

PI_NAMEs: AWAD, HANI A (contact);BENOIT, DANIELLE S.;CALVI, LAURA M

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Musculoskeletal;Science;Training

PROJECT_TITLE: Training in Musculoskeletal Science


NIH_SPENDING_CATS: Aging;Clinical Research;Nutrition

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Calorie restriction has been shown to be beneficial to healthspan and lifespan in multiple animal models. We have shown that depletion of riboflavin, also known as Vitamin B2, extends lifespan in the nematode worm in a model similar to calorie restriction. This project serves to investigate the mechanisms of how this occurs and whether riboflavin depletion can promote similar benefits in mammals, with the hope of identifying new treatments for aging associated diseases.

PI_NAMEs: YEREVANIAN, ARMEN I (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Adipocytes;Advisory Committees;Aging;aging related;aging related disease;Animal Model;Animals;Area;Automobile Driving;biological adaptation to stress;Biological Assay;Biological Availability;Biology;Biology of Aging;Body Composition;Caenorhabditis elegans;Caloric Restriction;career development;Cell Line;Cells;Cellular biology;Characteristics;cofactor;Data;Disease;Doctor of Philosophy;Dose;Down-Regulation;Environment;Enzymes;extend lifespan;Five-Year Plans;Flavin Mononucleotide;Flavin-Adenine Dinucleotide;Flavins;FOXO1A gene;Functional disorder;functional genomics;Funding;General Hospitals;gerotherapeutic;Goals;Health Benefit;healthspan;healthy aging;Hepatic;Hepatocyte;Human;insight;Insulin Resistance;knock-down;life span;lipid metabolism;Lipids;Longevity;Mammals;Massachusetts;Mediating;medical schools;Medicine;member;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Micronutrients;mid-career faculty;mimetics;Mitochondria;Modeling;Molecular;mouse model;Mus;Nematoda;Neurodegenerative Disorders;new therapeutic target;novel;Obesity;Organism;Orthologous Gene;Oxidases;oxidation;Oxidation-Reduction;Pathway interactions;Pharmacology;Phenotype;Physicians;Physiological;Physiology;Process;Production;professor;programs;protective effect;Reactive Oxygen Species;Regulation;Research;Research Personnel;Respiration;response;Riboflavin;Role;Scientist;Signal Transduction;skills;Succinate Dehydrogenase;Therapeutic;therapeutic target;Time;Tissues;tool;Training;translational model;translational potential;uptake;Vocational Guidance;Work;Yeasts

PROJECT_TITLE: Physiology of Lifespan Extension and Metabolic Hormesis with Riboflavin Depletion

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This proposal examines the molecular interactions between cells of the immune system and lung stem/progenitor and mesenchymal cell populations, focusing on their significance in coordinating alveolar epithelial regeneration. Immediate outcomes will be the identification and characterization of leukocyte-induced signals that promote the expansion, differentiation, and function of lung epithelial cells after severe injury. The concepts explored under this proposal will further our understanding of the cellular networks that mediate regeneration of damaged distal lung tissue and have potential broader applications in the development of therapeutics aimed at reversing associated pathophysiology.

PI_NAMEs: ARPAIA, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Acute;Acute Lung Injury;airway regeneration;Alveolar;alveolar epithelium;Amphiregulin;Anatomy;Binding;cell type;Cells;Chronic;Cues;Development;disease model;Distal;Environment;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Exhibits;Functional disorder;Future;Gene Expression Profile;Genetic;Goals;Growth Factor;Homeostasis;Image;Immune;Immune response;Immune signaling;Immune system;immunological diversity;Impairment;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;influenza infection;influenzavirus;Injury;interdisciplinary approach;Kinetics;Leucocytic infiltrate;Leukocytes;Ligands;Link;Lung;Lung Diseases;lung injury;lung preservation;lung regeneration;lung repair;Lymphocyte;Mediating;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Modeling;Molecular;Mus;Natural regeneration;Organ;organ growth;Outcome;pathogen;Pathogenicity;Pattern;Phase;Physiological;Play;Population;Process;Production;progenitor;programs;Proliferating;protective factors;pulmonary function;recruit;regenerative;Regenerative Medicine;Regulation;Regulatory T-Lymphocyte;repaired;Report (document);Resolution;response;restoration;Role;severe injury;Severities;Signal Induction;Signal Transduction;skin wound;Source;Spatial Distribution;stem;stem cell population;stem cells;Sterility;Stimulus;Structure of parenchyma of lung;Supporting Cell;T-Lymphocyte;Testing;therapeutic candidate;therapeutic development;tissue injury;tissue regeneration;tissue repair;Tissues;tool;Tumor Immunity;Viral Respiratory Tract Infection;Wound models

PROJECT_TITLE: Lung leukocytes promote alveolar epithelial regeneration after severe injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Telehealth;Violence Research

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Over two-thirds of children experience traumatic events such as child maltreatment, violence, or sudden or violent loss, which often results in significant developmental and emotional difficulties. Emotional support from a caregiver is theorized to buffer against the effects of trauma; however, many caregivers lack the self-efficacy and skills to support their child and existing caregiver interventions are lengthy (lasting 8-20 sessions) and result in families placed on long waitlists. The present research addresses this gap in the literature by examining the feasibility, acceptability, and preliminary efficacy of the telehealth delivery of the Project Support Positive Parenting Module, a brief parenting intervention designed to enhance caregiver support, among families on the waitlist for trauma-focused services.

PI_NAMEs: RANCHER, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Address;Adverse effects;Affect;Aggressive behavior;Applied Skills;Area;Attitude;Award;barrier to care;Benchmarking;brief intervention;Buffers;career;caregiver interventions;Caregiver support;Caregivers;Caring;Characteristics;Child;Child Abuse and Neglect;Child Development;Child Rearing;child services;Communication;Consolidated Framework for Implementation Research;Consultations;contextual factors;COVID-19 pandemic;Data;design;Development;Disadvantaged;dissemination strategy;Educational process of instructing;Educational workshop;effective intervention;effectiveness testing;Emotional;Ensure;Epidemic;experience;Faculty;Family;Funding;Future;Goals;health disparity;Health Personnel;Hybrids;implementation framework;implementation science;improved;innovation;Instruction;Interruption;Intervention;Interview;Knowledge;Literature;Mediator;Mental Health;Mentors;Mentorship;Methodology;Methods;Modeling;parenting intervention;Patients;pediatric trauma;Persons;Phase;pilot trial;programs;Provider;Public Health;Qualitative Methods;Randomized, Controlled Trials;recruit;Research;Research Activity;Research Personnel;research study;response;Rural;satisfaction;scale up;Self Efficacy;service delivery;Services;skills;Statistical Data Interpretation;suicidal;Suspensions;Technology;telehealth;tenure track;Testing;theories;therapy design;Time;Training;Transportation;Trauma;trauma exposure;trauma symptom;traumatic event;traumatized children;treatment as usual;trend;Underserved Population;uptake;Videoconferencing;Violence;Waiting Lists;Work

PROJECT_TITLE: A Brief Intervention to Enhance Supportive Parenting and Treatment Engagement Among Families Waiting for Trauma-Focused Services

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Metabolic Syndrome (MetS) and its components, such as diabetes and obesity, in mid-life are associated with increased risk of cognitive impairment, dementia, and Alzheimer’s disease (AD) later in life. In this proposal, we will focus on understanding how mid-life MetS onset disrupts metabolism in oligodendrocyte cells that support neurons to define the mechanism that underlies how MetS leads to neuronal loss in the brain, and ultimately AD, in later life. By understanding the mechanisms that contribute to neuronal loss in MetS- associated AD, we can identify novel, targeted, translatable interventions to reduce MetS-related cognitive decline.

PI_NAMEs: NOURELDEIN, MOHAMED HUSSEIN MOHAMED (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;ATAC-seq;Bioenergetics;Brain;Cell Nucleus;Cerebrum;Clinical Research;Coculture Techniques;Cognition;cognitive function;Communication;cost estimate;Data;Dementia;dementia risk;Diabetes Mellitus;Disease;Dyslipidemias;Economic Burden;efficacy evaluation;Elements;Ensure;Epigenetic Process;epigenome;epigenomics;Functional disorder;Future;Gene Delivery;Glycolysis;Goals;Health Care Costs;High Fat Diet;Human;human old age (65+);Impaired cognition;Impairment;In Vitro;Insulin Resistance;Intervention;Knock-out;late life;Life;Mediating;Memory;Metabolic;Metabolic syndrome;Metabolism;middle age;Mitochondria;Modeling;multiple omics;Mus;neuron loss;Neuronal Injury;Neurons;new therapeutic target;novel;Obesity;old mice;Oligodendroglia;overexpression;oxidation;Pathway interactions;Persons;Phase;Physiological;pre-clinical research;Prevalence;protective effect;Research;Risk;Role;sex;Signs and Symptoms;single nucleus RNA-sequencing;socioeconomics;Supporting Cell;Testing;Thinness;transcriptome;transcriptome sequencing;transcriptomics;United States;Wild Type Mouse;Work

PROJECT_TITLE: Metabolic syndrome impairs oligodendrocyte metabolic support of neurons leading to Alzheimer’s disease/Alzheimer’s disease and related dementias

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SPRINGFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED

PHR: PROJECT NARRATIVE The incidence of autism spectrum disorder diagnosis (ASD) has risen to 1 in 54 children in the United States. This project is aimed at identifying potential neurobiological basis of ASD present in the cerebellum, a brain region implicated to be invovled in ASD based on clinical data. Results may provide a description of new sites within the nervous system that are uniquely senstive to perturbations that give rise to ASD and provide opportunities for ASD prediction, prevention, and treatment.

PI_NAMEs: RICHARDSON, BEN D (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Animal Model;Animals;Anxiety;Area;Attention;autism spectrum disorder;autism symptoms;Behavior;behavior influence;Behavioral;behavioral phenotyping;Birth;Brain;Brain region;brain shape;cell motility;Cell Nucleus;Cell Physiology;cell type;Cellular Morphology;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Child;Clinical;Clinical Data;Cognitive;Collection;Complex;Corpus striatum structure;Data;Development;Diagnosis;DNA Sequence Alteration;Emotional;Environmental Risk Factor;Excision;Face;Foundations;Functional disorder;Genes;Genetic;Genomics;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;granule cell;high risk;Human;Incidence;Knowledge;Link;link protein;Memory;migration;Molecular;Morphology;Motor;motor behavior;motor deficit;Motor Pathways;Mus;Mutant Strains Mice;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System;Nervous System Disorder;neural;Neurobiology;Neurodevelopmental Disorder;Neurons;Neurosciences;Output;Play;Population;postnatal;postnatal development;postsynaptic;Prevention;Preventive treatment;Process;Property;Purkinje Cells;receptor density;response;restorative treatment;Rewards;Role;Sensory;Shapes;Signal Transduction;Site;Slice;social;Social Behavior;spatiotemporal;Synapses;Synaptic plasticity;Synaptic Transmission;System;Time;transmission process;treatment strategy;United States;Variant;vestibular system;Work

PROJECT_TITLE: Cerebellar granule cell dysfunction in Shank3 mutant mice


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: PROJECT NARRATIVE Ketamine, an NMDA receptor blocker, shows promise in overcoming major unmet limitations of currently available antidepressants for treating major depressive disorder, because of its rapid and sustained antidepressant effects. This proposal will determine the influence of GABAergic cellular and synaptic mechanisms in the antidepressant actions of ketamine, and will extend this investigation to additional GABAergic compounds, including ?-GABAA-R modulators. These findings will contribute to a novel hypothesis about how fast-acting antidepressants result in rapid and sustained behavioral changes, guiding efforts to develop a new generation of more specific drugs to treat MDD.

PI_NAMEs: FOGACA, MANOELA  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: abuse liability;Address;Aftercare;Animals;anti-depressive agents;antidepressant effect;Area;Behavioral;behavioral outcome;behavioral response;Brain;Calcium;calmodulin-dependent protein kinase II;cell type;Clinical;Clinical Trials;Complex;Data;density;Development;Disinhibition;Drug Targeting;Equilibrium;excitatory neuron;Functional disorder;Future;gamma-Aminobutyric Acid;Generations;Genetic;genetic approach;glutamatergic signaling;Glutamates;Goals;hippocampal pyramidal neuron;in vivo;inhibitory neuron;Interneurons;Investigation;Ketamine;knock-down;Literature;Major Depressive Disorder;Medial;Mediating;Mental Depression;Molecular;N-Methyl-D-Aspartate Receptors;neural circuit;Neurons;novel;novel therapeutics;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physiology;preclinical study;Prefrontal Cortex;Protein Biochemistry;Protein Biosynthesis;receptor;receptor function;Resistance;response;Rodent;Role;Scientific Advances and Accomplishments;side effect;Signal Transduction;Stress;Synapses;Synaptic plasticity;synaptogenesis;System;Testing;Time;translational study;Translations;treatment response;Universities;Vertebral column;Work

PROJECT_TITLE: Cortical GABAergic mechanisms underlying rapid and sustained antidepressant responses

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences

PHR: Project Narrative Variants of the Apolipoprotein E (APOE) gene are associated with risk of developing Alzheimer's disease (AD). This project will explore the role of APOE variants in the adaptive immune response to pathogenic viruses in AD. The study will utilize genomic, proteomic and immunohistochemical approaches to interpret APOE-associated adaptive immune changes to viral antigens in AD.

PI_NAMEs: GATE, DAVID  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Abeta clearance;adaptive immune response;adaptive immunity;Affect;African American;African ancestry;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;analog;Antigens;antiviral immunity;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Autopsy;B-Cell Antigen Receptor;B-Lymphocytes;Bar Codes;Binding;Bioinformatics;Biology;Blood;Brain;brain cell;BZLF1 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;cell killing;Cells;Cerebrospinal Fluid;Circulation;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Communicable Diseases;cytokine;Data;Deep Cervical Lymph Node;Deposition;differential expression;disorder risk;effector T cell;Epitopes;experience;Gene Modified;Genes;Genetic Determinism;Genomics;Genotype;Germ Cells;Hematological Disease;Human Herpesvirus 4;Immune;Immune response;Immunity;Immunohistochemistry;immunoregulation;Individual;Induced Neurons;Inflammatory;Intrathecal Space;Lasers;Liquid substance;Measures;Meningeal lymphatic system;Microdissection;Nerve Degeneration;neuroinflammation;Neurology;Neurons;neurotoxicity;novel;pathogen;pathogenic virus;Pathologic;Pathway Analysis;Patients;Peptides;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Population;Predisposition;Process;Property;Proteomics;receptor;Research Personnel;Risk;RNA;Role;single-cell RNA sequencing;Source;Specimen;statistics;Structure;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Testing;theories;Transcription Alteration;transcriptome;transcriptomics;Universities;Variant;Viral;Viral Antigens;Virus Diseases

PROJECT_TITLE: The role of apolipoprotein E in Alzheimer's adaptive immunity


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The brainstem controls life-sustaining orofacial movements, including suckling, chewing, swallowing, and airway patency, and determining the neuronal circuit mechanisms that regulate these behaviors can provide crucial information to understand more general mechanisms of brain function. Additionally, deficits in orofacial control and the return of primitive oral reflexes in adults, including rooting and suckling, are prominent symptoms of neurodegenerative disease, such as Parkinson’s disease and vascular dementia. Understanding how these behaviors are controlled in the healthy brain can help to identify the cause of these pathologies and how to treat them.

PI_NAMEs: MOORE, JEFFREY DANIEL (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Ablation;Adult;Amygdaloid structure;Animals;Area;Award;Axon;Behavior;Behavior Control;behavior test;Behavioral;Brain;brain control;Brain region;Brain Stem;cell type;Code;Complex;Cre driver;Cues;Data;Decision Making;Deglutition;Elements;Engineering;Ensure;Environment;Exhibits;experimental study;Exploratory Behavior;Face;feeding;Feeding behaviors;Genetic;Genetic Techniques;Goals;Head Movements;Hypothalamic structure;Immediate-Early Genes;in vivo;Infant;Investigation;Knowledge;Label;Legal patent;Life;Link;Logic;Mammals;Maps;Mastication;mature animal;Measures;Mediating;Mentors;Modernization;Molecular;molecular marker;Monitor;Mothers;Motivation;Motor;motor behavior;Motor Neurons;Movement;Mus;Nervous System;Neurobiology;Neurodegenerative Disorders;neuronal circuitry;Neurons;Neuropeptide Gene;Neuropeptide Receptor;Neurosciences;Newborn Infant;Nipples;Nose;novel;optogenetics;oral reflex;orofacial;Output;Parkinson Disease;Pathology;Pathway interactions;Pattern;Phase;Physiological;Play;Population;Positioning Attribute;postnatal;postnatal development;preference;presynaptic;Prosencephalon;Proteins;Reporting;Research;Research Personnel;Rodent;Role;Sensory;Shapes;skills;Structure;Study models;sucking;suckling;Surveys;Symptoms;Synapses;System;Techniques;Testing;Time;tool;Tracer;Training;Universities;Vascular Dementia;vector;Vibrissae;Viral;Viral Vector;Work

PROJECT_TITLE: Descending engagement of brainstem neuronal circuits that govern orofacial motor behaviors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NORTH CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: PROJECT NARRATIVE Idiosyncrasy is a fundamental trait in decision-making that impacts one’s life tremendously, and life-threating, maladaptive choice behavior in neurological/psychiatric disorders might in part stem from malfunctions of the neural circuits controlling idiosyncratic decisions. Recent scientific findings raise a compelling hypothesis that a posterior network in the brain may be central to the control of idiosyncratic choice biases. This project will test this hypothesis and elaborate information processing in the posterior network using advanced computational models and circuit interrogation tools in rodents, the gained knowledge from which will guide future research to identify the neural basis of pathological decision-making.

PI_NAMEs: HWANG, EUN JUNG  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: addiction;Address;Affect;Aging;anatomical tracing;Anatomy;Area;Axon;Behavior;Brain;Choice Behavior;cingulate cortex;Clinical;Code;Cognitive;Complex;Computer Models;Corpus striatum structure;Decision Making;Dementia;Disease;Exhibits;experience;experimental study;Foundations;Image;Individual;information processing;insight;interest;Knowledge;Label;Life;Mediating;Memory;Mental disorders;Modeling;motor control;Mus;neural;neural circuit;Neural Pathways;Neurologic;Neurons;Noise;optogenetics;Outcome;Output;Parietal Lobe;Pathologic;Pathway interactions;Persons;postsynaptic;presynaptic;Process;Recording of previous events;Reporting;response;Response to stimulus physiology;Rodent;Role;Sensory;Series;Signal Transduction;stem;Stimulus;Synapses;Testing;tool;Tracer;trait;transmission process;two-photon

PROJECT_TITLE: Neural circuits for decision making

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat mental illness depends on our understanding of how the nervous system processes information related to complex behaviors. The research described in this proposal will establish a new system to study how the norepinephrine system alters information processing in the cerebral cortex and how these changes effect decision making. If successful, this work will uncover basic principles of how decision related signals are processed by cortical circuits and how noradrenaline signaling flexibly alters cognition.

PI_NAMEs: SCOTT, BENJAMIN B (contact)

PROJECT_TERMS: Address;Affect;Behavior;Behavioral;Calcium;cell type;Cerebral cortex;Cognition;Cognition Disorders;Cognitive;Color;Complex;Computer Models;Data;Decision Making;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Disease;Enhancers;Environment;experimental study;flexibility;Foundations;genetic effector;genetic manipulation;Genetic Markers;Human;Image;Imaging Device;Immediate-Early Genes;Immunohistochemistry;improved;Impulsivity;in vivo;in vivo imaging;in vivo optical imaging;Individual;information processing;Injections;Knowledge;Link;locus ceruleus structure;Measurement;Measures;Mental disorders;Modeling;Mood Disorders;Motor Cortex;Nervous System;neural;neural circuit;neural model;Neurodevelopmental Disorder;neuroimaging;neuromechanism;Neurons;neuropsychiatric disorder;Norepinephrine;norepinephrine system;novel;Organism;Output;Pattern;pharmacologic;Physiological;Physiology;Play;Population Dynamics;predictive modeling;Process;Public Health;Rattus;redshift;Research;Resolution;response;Rodent;Role;role model;Satellite Viruses;selective expression;sensor;Sensory;sensory cortex;sensory input;Signal Transduction;spectrograph;System;Testing;theories;tool;Training;Visual Cortex;Work

PROJECT_TITLE: The Role of the Locus Coeruleus-Norepinephrine System in Flexible Decision-Making


PHR: PROJECT NARRATIVE Glycation is an unexplored non-enzymatic post-translational modification that has only recently emerged as a mechanism of gene regulation. Here, I propose a comprehensive study that will utilize cutting-edge proteomics and gene and metabolic perturbations to understand its biological significance. Importantly, the findings will lead to clinical advancements particularly against age-related and metabolic diseases as well as cancer.

PI_NAMEs: SANGHVI, VIRAJ  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;adduct;Affinity;age-related disease;Amino Acids;Biological;cancer therapy;cell behavior;Clinical;clinical application;detection of nutrient;Diabetes Mellitus;Elongation Factor;Enzymes;Excision;Foundations;Future;Gene Expression Regulation;Genes;Glucose;glycation;Histones;Hyperglycemia;inhibitor;insight;Isotope Labeling;Kinetics;Link;Malignant Neoplasms;Medical;Medicine;Metabolic;Metabolic Diseases;Metabolism;Metadata;Nutrient;Nutrient availability;PARK7 gene;Pathway interactions;Peptide Initiation Factors;Physiology;Post-Translational Protein Processing;preference;programs;protein function;Proteins;Proteomics;Reaction;Regulation;Research;Resolution;response;Role;Side;Signal Transduction;small molecule;stoichiometry;sugar;underserved area;Vision

PROJECT_TITLE: Understand Glycation: The Sweet Side of Protein Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE There is a clear need to train academic physicians and scientists to perform research in gastroenterology in order to sustain the future generations of scientists and to maintain our edge in scientific excellence and innovation worldwide. This proposal puts together a training program which consolidates the major investigators conducting gastrointestinal research at the University of Michigan into a strong core of mentors to address this unmet need. Support is requested for 2 postdoctoral trainees and 3 predoctoral candidates selected from the University of Michigan program in biological sciences.

PI_NAMEs: KAO, JOHN Y (contact);SAMUELSON, LINDA C.

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Science;Training

PROJECT_TITLE: Training in Basic and Translational Digestive Sciences


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PHR: Project Narrative The proposed work is relevant to public health and to the mission of the National Institute of Dental and Craniofacial Research to reduce inequality in oral health care, because it will test the impact of addressing adverse social determinants of health on patients’ ability to access oral health care. The study addresses unmet oral health needs in emergency department patients, who are most likely to have high social needs and also most likely to lack access to routine oral health care.

PI_NAMEs: SAMUELS-KALOW, MARGARET EMILY (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;adverse outcome;Antibiotics;Area;Caring;Color;Communities;community partners;comorbidity;density;Dental;Dental Clinics;dental infection;Dental Insurance;Dentists;Development;Diagnostic Procedure;Diagnostic tests;Disease;Disparity;Effectiveness of Interventions;effectiveness/implementation study;Emergency Care;Emergency Department patient;Emergency department visit;Enrollment;Ensure;ethnic minority;food insecurity;Frequencies;Geographic Distribution;Geography;Goals;Grant;Health;health disparity;health goals;health inequalities;Health Personnel;health related quality of life;Health Resources;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;High Prevalence;Homelessness;implementation framework;implementation strategy;Improve Access;improved;improved outcome;Individual;Inequality;Insurance;Interdisciplinary Study;Intervention;Intervention Trial;Low income;Maps;Medicaid;Mission;Modeling;Morbidity - disease rate;Mouth Diseases;National Institute of Dental and Craniofacial Research;Neighborhoods;opioid use disorder;Oral health;Outcome;Paper;participant enrollment;patient oriented;patient population;Patients;Policies;Population;Populations at Risk;prescription opioid;Primary Care;primary outcome;Process;Proctor framework;Provider;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Research;Resources;Risk;Risk Factors;Role;safety net;satisfaction;Schools;screening;Screening procedure;secondary outcome;Site;social;social health determinants;standard care;standard of care;Strategic Planning;success;successful intervention;Technology;Telephone;Testing;Text Messaging;Time;Tooth Diseases;Toothache;Treatment Efficacy;Visit;Vulnerable Populations;Work

PROJECT_TITLE: MOLAR: Mapping Oral health and Local Area Resources


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Antiretroviral therapy (ART) during HIV-1 infection suppresses viral replication and prevents immunodeficiency but does not cure the infection. We have developed a novel genetically encoded humanized mouse model system that enables us to distinguish latent cells from bystander cells and are now characterizing latent cells using single cell genomic profiling of cells, to reveal an unprecedented unperturbed view HIV latency. We propose here to use single cell genomics, live dynamic imaging and spatial transcriptomics to probe how latent cells survive stimuli that can activate the virus and the immune system.

PI_NAMEs: CHEN, BENJAMIN K (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;acute infection;Animal Model;Animals;Antibodies;antiretroviral therapy;Bar Codes;Behavior;Binding;Biological;Biological Models;CD4 Positive T Lymphocytes;Cell Communication;Cell Count;Cell Lineage;Cell Survival;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Classification;Development;Disease Progression;Gastrointestinal tract structure;Gene Expression Profile;Genes;Genetic Transcription;genomic profiling;Genomics;HIV;HIV Infections;HIV-1;Human;humanized mouse;Image;Immune system;immunodeficiency;improved;In Vitro;in vivo;Infection;Interruption;Intervention;Knowledge;Maps;Measures;Memory;Methods;migration;Modeling;Morphology;mouse model;Mucous Membrane;multiple omics;Mus;novel;Pathway Analysis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;preservation;prevent;programs;Proliferating;purge;Relapse;Research;Resolution;response;Shock;single cell genomics;single-cell RNA sequencing;Spleen;Stimulus;Superantigens;System;Systems Biology;T-Cell Activation;T-Lymphocyte;TCR Activation;Testing;Time;Tissue-Specific Gene Expression;Tissues;transcriptomics;Viral;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Single cell transcriptomics of HIV persistence and latency

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In this proposal we aim to continue to understand the mechanisms involved in antigen archiving that lead to protective immune responses. These studies will provide a more in depth understanding of the cellular processes and communication necessary for the handling of antigens over time in order to benefit protective immunity.

PI_NAMEs: TAMBURINI, BETH ANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Affect;antigen detection;Antigen Presentation;Antigens;Archives;Attenuated Vaccines;Award;Bar Codes;Caveolins;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Shape;cell type;Cells;Cellular Immunity;Communication;Conjugate Vaccines;Data;Dendritic Cells;design;Development;DNA;emerging pathogen;Event;Exocytosis;Flow Cytometry;Funding;Future;Gene Expression Profile;Genes;Genetic Transcription;genomic platform;grasp;Hand;Hematopoietic;ICAM1 gene;Immune response;Immunity;Immunologic Memory;improved;Infection;Inflammation;Inflammatory;Lead;Learning;lymph nodes;Lymphatic;Lymphatic Endothelial Cells;Measures;Memory;Messenger RNA;Methodology;Methods;Molecular;novel;prevent;Process;programs;Proliferating;protein degradation;Proteins;Publishing;secondary infection;Secondary to;Signal Transduction;single cell mRNA sequencing;Source;subcutaneous;Surface;T cell response;T memory cell;Techniques;Technology;Time;Tissues;trafficking;transcriptome;Vaccination;vaccination strategy;Vaccine Design;vaccine strategy;Vaccines;Viral;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: Cooperation between lymphatic stroma and hematopoietic cells shapes protective immunity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA STATE DEPARTMENT OF HEALTH

ORG_STATE: IN

PHR: Project Narrative The Indiana Department of Health – Food Protection Division is committed to maintaining high regulatory program standards. The objectives outlined in this proposal will enable the division to not only meet, but exceed these standards by shifting program resources to a more preventive and collaborative approach to food safety regulation and illness prevention.

PI_NAMEs: MCCURDY, VIVIEN  (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, JENNIFER

PROJECT_TITLE: MFRPS Maintenance - Indiana Department of Health Food Protection Division

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-J (16)]


NIH_SPENDING_CATS: Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE I propose a biologically motivated, mathematical modeling approach to understand how neuroimaging and other biomarkers can be used to better understand Alzheimer’s disease biology. I plan to fit mechanistic models to data from 3 cohorts across the age span of Alzheimer’s disease onset: Longitudinal Early Onset Alzheimer’s Disease Study (LEADS) (ages 40-64), Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort (ages 55-90), and The 90+ Study (ages 90+). The long-term objective of this research is to improve our understanding of the age-specific pathophysiology of Alzheimer’s disease, determining the precise relationship between tau and cognition, with the ultimate goal of guiding therapeutic development and trials for Alzheimer’s treatment.

PI_NAMEs: ACKLEY, SARAH  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;Age;age difference;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid;Atrophic;Biological;Biological Markers;Biology;Blood Vessels;blood-based biomarker;Brain;California;Clinical;Cognition;cognitive change;cohort;college;Communicable Diseases;Complex;Computational Biology;computerized tools;Data;Drug Targeting;Early Onset Alzheimer Disease;experience;Functional disorder;Goals;Guidelines;hands on research;Heterogeneity;Impaired cognition;improved;Individual;Infectious Disease Epidemiology;Intervention;Knowledge;Late Onset Alzheimer Disease;Lead;life span;Light;Link;Location;London;Magnetic Resonance Imaging;mathematical model;Mathematics;Measurement;Measures;Mentors;Mentorship;Modeling;multimodality;Neurofibrillary Tangles;neurofilament;neuroimaging;Neuropsychology;Onset of illness;Outcome;Pathologic Processes;Pathology;Physiological;Positron-Emission Tomography;professor;Research;Research Activity;Structure;System;targeted treatment;tau aggregation;tau Proteins;Techniques;therapeutic development;Therapeutic Trials;Time;Training;Training Activity;treatment duration;trial design;Universities;White Matter Hyperintensity

PROJECT_TITLE: Mathematical Models of Tau-PET Measures and Cognitive Decline in Alzheimer's Disease Across the Lifespan


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The proposed work will develop training aimed at increasing the number of scientists proficient in and funded for optimization of behavioral and biobehavioral interventions. The work of these scientists will, in turn, produce more effective, efficient, economical, and scalable interventions, and thereby improve the nation’s health in substance abuse, HIV, cancer, and countless other important areas of public health.

PI_NAMEs: COLLINS, LINDA M (contact);GUASTAFERRO, KATELYN

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Applications Grants;Area;Award;Behavioral;Behavioral trial;biobehavior;career;Consultations;course introduction;design;Development;Diabetes Mellitus;Disease;Educational Status;effective intervention;Effectiveness;experience;flipped classroom;fundamental research;Funding;graduate student;Growth;Health;HIV;improved;innovation;Instruction;Intervention;Malignant Neoplasms;Mentorship;Methodology;Mission;multiphase optimization strategy;National Institute of Drug Abuse;obesity treatment;outreach;Piper;Play;Postdoctoral Fellow;Preparation;prevent;Public Health;Randomized;randomized, clinical trials;Research;Research Personnel;Resources;response;Role;Science;Scientist;secondary analysis;Series;skills;Substance abuse problem;Substance Use Disorder;summer institute;therapy development;Training;United States National Institutes of Health;Update;virtual;web site;webinar;Work;Writing

PROJECT_TITLE: Optimization of behavioral and biobehavioral interventions: Building investigator capacity nationwide

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-R (50)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

PHR: Post-traumatic stress disorder (PTSD) afflicts approximately one in six Veterans returning from the Iraq and Afghanistan combat arenas. Studies have shown an immune imbalance toward inflammatory reactivity in PTSD patients, and animal models of PTSD have implicated this immune imbalance as a contributor to PTSD following the initial trauma. Currently available treatments for PTSD are only effective in about half of Veterans with PTSD, which underscores the need for alternate treatment approaches. The proposed studies aim to define the immune imbalance in Veterans with PTSD and determine how this can lead to brain inflammation. These studies will also pave the way for novel immunotherapeutic approaches for PTSD as they will explore approaches to restore immune balance, thereby mitigating brain inflammation and its impact on behavior.

PI_NAMEs: WANG, ZHEWU  (contact)

PROJECT_TERMS: Acute;Afghanistan;Animal Model;Anxiety;Behavior;Biological Response Modifiers;Blood;Brain;brain behavior;brain cell;Cells;Chronic Disease;Clinical;combat;combat veteran;combat zone;cytokine;Development;Disease;Encephalitis;Equilibrium;Freedom;Goals;Health;Human;human subject;Immune;immune activation;immune function;Immunologics;Immunotherapeutic agent;improved;Inflammation;Inflammation Mediators;Inflammatory;Iraq;Leukocytes;Measures;Microglia;military veteran;neuroinflammation;novel;operation;Outcome;Patients;Peripheral;Personal Satisfaction;Pharmacological Treatment;Phenotype;Post-Traumatic Stress Disorders;Property;psychologic;Psychological Stress;Reporting;Risk;Saliva;service member;Specimen;Stress;Symptoms;Testing;Trauma;trauma exposure;treatment response;treatment strategy;United States Department of Veterans Affairs;Veterans;volunteer;War

PROJECT_TITLE: Dysregulated Immune State in PTSD Contributes to Microglial Inflammation

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: This study aims to systematically examine Medicaid health plan policies related to delivery and management of opioid use disorder treatment. Findings from this study will help health plan administrators as they develop and implement plan policies, state Medicaid directors as they contract with health plans and federal policy makers making determinations about Medicaid policy, to help stem the tide of the opioid crisis and its often-deadly consequences.

PI_NAMEs: HODGKIN, DOMINIC  (contact);STEWART, MAUREEN T

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: addiction;Address;Administrator;Adopted;Affect;Affordable Care Act;Area;behavioral health;Buprenorphine;care outcomes;Caring;Characteristics;Complex;Contracts;copayment;Data;Decision Making;density;design;District of Columbia;Effectiveness;Equity;Evidence based treatment;FDA approved;Federal Government;federal policy;Fee-for-Service Plans;flexibility;Funding;General Population;Headache;Health Benefit;health care service;Health Insurance;health management;health plan;Health Services;Health Services Accessibility;Individual;innovation;Knowledge;Link;Managed Care Programs;Marketing;Medicaid;Medicaid eligibility;Mental Health;Methadone;Naltrexone;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Overdose;parity;Patient-Focused Outcomes;Patients;payment;Persons;Pharmaceutical Preparations;Pharmacotherapy;physical health service;Police;Policies;Policy Maker;Population;prior authorization;Privatization;programs;Provider;Qualifying;Research;response;Services;social stigma;State Government;stem;Substance Use Disorder;Surveys;treatment services;United States;Variant;waiver;willingness

PROJECT_TITLE: Examining opioid use disorder treatment in Medicaid managed care plans: policies and outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-C(05)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative We will optimize a unique calcium sensor that can record brain activity in freely-moving mice without any attached optical device to enhance its detection sensitivity for various experimental paradigms. Our optimization pipeline will utilize multiple testing steps, including large-scale testing in vivo, in order to enhance the predictivity of the screening assay. The new sensor will facilitate new types of hypothesis-driven experiments to dissect the distinctive properties of cells that are active in a specific task using either the dynamic recording capabilities of the sensor, optogenetic stimulation, or single-cell sequencing methods.

PI_NAMEs: CAMPBELL, ROBERT E.;DANA, HOD MICHAEL (contact);PAQUET, MARIE-EVE

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: advanced system;Affinity;age related changes;Age related pathologies;Area;Behavior;Behavior assessment;behavior test;behavioral study;Benchmarking;Binding;Biological Assay;Brain;Brain region;Calcium;Calcium ion;cell type;Cells;Characteristics;cognitive testing;Color;cortex mapping;Data;Detection;detection sensitivity;Development;Devices;Dorsal;Ensure;Environment;Equipment;experience;experimental study;flexibility;Fluorescence;Future;Genes;Genetic Identity;Goals;Head;Hippocampus;imaging system;Immunohistochemistry;Implant;implantable device;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;in vivo evaluation;interest;Label;Libraries;Light;Lighting;Link;Maps;Measurement;Methods;Microscope;Microscopy;millimeter;miniaturize;Monitor;Movement;Mus;Mutate;Mutation;neural circuit;Neurons;Noise;novel strategies;optical imaging;Optics;optogenetics;Pattern;Performance;Population;Positioning Attribute;predictive test;Process;Property;Protein Engineering;protein expression;protein purification;Proteins;Research;Resolution;response;sample fixation;Sampling;screening;sensor;Signal Transduction;single cell sequencing;Step Tests;Surface;System;Techniques;Technology;Testing;three photon microscopy;Tissues;translational neuroscience;two-photon;Variant;Viola;Viral Vector;Visual Cortex

PROJECT_TITLE: Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice


NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: CINCINNATI

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative The fundamental purpose of this training program is to provide surgical residents, pediatric critical care medicine fellows, and conventional PhD postdoctoral fellows with an intensive two-year research training experience that will prepare them for an academic career in trauma and critical care. The training program is designed to teach trainees how to assess a trauma-related problem, identify the key questions, formulate hypotheses, and then design and conduct the appropriate experiments to test the hypotheses and answer the questions.

PI_NAMEs: LENTSCH, ALEX B. (contact);ZINGARELLI, BASILIA

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Immune response;Training Programs;Trauma Research

PROJECT_TITLE: Host Response to Trauma Research Training Program


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Cancer;Comparative Effectiveness Research;Data Science;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Using machine learning to determine treatment efficacy and predict survival for cancer patients has not been well studied. The proposed research will provide novel methods to enable training of machine learning models on observational data that improve treatment effect estimation and prediction of clinical endpoints, such as survival time and treatment response.

PI_NAMEs: HUSSAIN, ZESHAN M (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Beds;Benchmarking;Biological Markers;Cancer Biology;cancer care;cancer cell;cancer heterogeneity;Cancer Patient;cancer survival;cancer therapy;Caring;Case Study;Cause of Death;Cessation of life;Chronic Disease;Chronic Kidney Failure;Clinical;clinical care;clinical decision support;clinical decision-making;clinical predictors;Combination Drug Therapy;Combined Modality Therapy;common treatment;Confidence Intervals;cost effective;Cystic Fibrosis;Data;Data Set;Decision Making;Diagnosis;Disease;disease registry;Early Diagnosis;Effectiveness;efficacy evaluation;Elements;Ethics;Evaluation;Future;Goals;improved;innovation;insight;Knowledge;Learning;learning algorithm;Machine Learning;machine learning method;machine learning model;Malignant Neoplasms;method development;Methodology;Methods;Modeling;Multiple Myeloma;multiple myeloma M Protein;neoplasm registry;novel;Observational Study;Outcome;Output;Parkinson Disease;patient biomarkers;Patients;Physicians;Plasma Cells;Prediction of Response to Therapy;prevent;prognostication;Progression-Free Survivals;prospective;Randomized, Controlled Trials;rare cancer;Recurrence;Research;Resources;response;Running;Sample Size;Sampling;Serum;Severities;Signal Transduction;support tools;survival prediction;Testing;Time;tool;Training;transcriptome sequencing;treatment effect;Treatment Effectiveness;Treatment Efficacy;treatment response;treatment strategy;Triplet Multiple Birth;tumor heterogeneity;tumor progression;Visualization;Work

PROJECT_TITLE: Machine Learning Methods to Predict Cancer Progression and Estimate Treatment Effectiveness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE The CREST Program, active since 2005, has trained over 88 physician scientists to date. Our provision of remote learning of biostatistical and clinical research methods combined with mentored team science and networking will be further enhanced with career development and leadership training to prepare the next generation of leaders in our field.

PI_NAMEs: SANTORO, NANETTE F. (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Acceleration;American;Assisted Reproductive Technology;Attention;Behavioral Research;Behavioral Sciences;Biomedical Research;Biometry;career;career development;Caring;Clinical;Clinical Investigator;clinical practice;Clinical Research;Clinical Sciences;Colorado;Committee Members;Communities;Data;Data Analyses;Department chair;design;Discipline of obstetrics;Distance Learning;Education Projects;Endocrinologist;equity, diversity, and inclusion;evidence base;Evolution;experience;follow-up;Fostering;Funding;Future;Goals;Gynecology;Home;improved;Individual;Infertility;Institution;Investments;Journals;Leadership;Medical;medical schools;medical specialties;Medicine;member;Mentors;Mentorship;Methodology;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;next generation;Pathway interactions;patient population;Peer Review;Physicians;Practice Guidelines;Process;Professional Organizations;Program Evaluation;programs;Protocols documentation;Publications;recruit;reproductive;Reproductive Endocrinology;Reproductive Medicine;Research;Research Methodology;Research Personnel;response;Role;Scholars Program;Science;Scientist;senior faculty;Shapes;Societies;Structure;success;Time;Training;Training Programs;Underrepresented Populations;Universities

PROJECT_TITLE: The Clinical Research/Reproductive Scientist Training Program (CREST)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Contraception/Reproduction;Endometriosis;Genetics;Pain Research;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Center for Engineering Endometriosis Care This project seeks to reframe how clinicians, scientists, and patients work together to understand the complexity of endometriosis, by more carefully measuring features of the patient experience, and using patient tissues to build models of disease that are specific for each patient. These models will be used to test why current drugs fail in patients, and to identify targets for new drugs, to improve options for patients who are in pain and are infertile.

PI_NAMEs: GRIFFITH, LINDA G (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 16 year old;Address;Age;Age of Onset;Animals;Awareness;base;Basic Science;Biochemical;Biological;Biophysics;Biopsy;Caring;Cells;Chronology;Classification;Clinic;Clinical;Clinical Data;clinical phenotype;Clinical Sciences;cohort;Communication;Communities;Complex;Cues;Data;design;Disease;disease model;Education;Educational Activities;Endocrine;endometriosis;Engineering;Etiology;Evaluation;experience;Genetic Predisposition to Disease;Goals;Grouping;High Prevalence;hormone therapy;Hormones;Human;Immune system;improved;In Vitro;in vitro Model;in vivo;Infertility;Inflammation;insight;Integration Host Factors;Intervention;Investigation;Knowledge;Language;Lesion;Link;Liquid substance;Macrophage;Maintenance;Measures;Metabolic;microphysiology system;model building;model design;Modeling;Molecular Profiling;Morphology;new therapeutic target;next generation;Operative Surgical Procedures;organ on a chip;outreach program;Pain;patient subsets;Patients;Penetration;Peritoneal;Peritoneal Fluid;Pharmaceutical Preparations;Phenotype;Physiology;Progressive Disease;Publishing;Research;Research Personnel;response;Sampling;Scheme;Scientist;Side;Signal Transduction;Site;Source;Stratification;Subgroup;Superficial Lesion;Symptoms;Systems Biology;Technology;Testing;Tissue Engineering;Tissues;tool;Treatment Protocols;Work

PROJECT_TITLE: Parsing the Interplay Between Biophysical and Biochemical Microenvironment Cues On Endometriosis Lesion Phenotypes Using Microphysiological Systems