ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Infants with medical complexity are a medically vulnerable population with high emergency department and inpatient resource use, disparities in care (notably among rural populations), and significant adverse emergency health outcomes. Through the proposed training and research plan, the PI will optimize and implement an advanced emergency care planning tool for infants with medical complexity through a user- centered dissemination and implementation science approach.

PI_NAMEs: PULCINI, CHRISTIAN DONALD (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Academy;Accident and Emergency department;acute care;Address;Admission activity;Adoption;American;care outcomes;career development;Caregivers;Child;Child Advocacy;Child Care;Childhood;Chronic;clinical care;Clinical Investigator;Clinical Trials;Clinical Trials Design;college;Complex;cost;Cost Effectiveness Analysis;Cost Measures;Data;Dedications;design;Development;Disparity;Dissemination and Implementation;dissemination science;Dose;Emergency Care;Emergency Department Physician;Emergency department visit;Emergency Health Services;Emergency Medicine;Emergency Situation;Ensure;ethnic minority;experience;Expert Opinion;Family;family burden;feasibility trial;Future;Goals;Health;health care disparity;health care service utilization;Health Services;Health Services Research;Healthcare;high risk;implementation barriers;implementation process;implementation science;implementation tool;implementation trial;improved;improved outcome;Infant;Infant Care;infant outcome;innovation;Inpatients;Intervention;Interview;Length;Life;low socioeconomic status;Maternal and Child Health;Measures;Medical;Medical Technology;medical vulnerability;meetings;Mentors;Mentorship;Monitor;Outcome;patient population;patient subsets;pediatric emergency;Pediatrics;Pharmaceutical Preparations;Physicians;Positioning Attribute;Professional Organizations;Provider;Publishing;Quality of Care;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Training;Resources;rural area;Rural Population;rural setting;Scientist;Site;skills;Structure;Subgroup;Surveys;Time;tool;Training;Training Programs;uptake;user centered design;Vermont;Vulnerable Populations;Work

PROJECT_TITLE: Optimization and Implementation Trial of a User-Centered Emergency Care Planning Tool for Infants with Medical Complexity

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The prevalence of human papillomavirus (HPV)-related oropharynx cancer is increasing, patients have a 20% risk of dying within 5 years of diagnosis with this disease, and treatment often has severe negative effects on long-term quality of life. We’ve characterized two main types of this disease that depends on whether HPV has become integrated into the patient’s own genome in their tumor cells. In this grant, we will study the effects of HPV integration and their relationship with survival, with the goal to improve patient’s quality of life and chance of survival.

PI_NAMEs: D'SILVA, NISHA J;ROZEK, LAURA ;SARTOR, MAUREEN AGNES (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Address;Affect;Age;Alcohol consumption;Animal Model;Automobile Driving;Biological Assay;Biological Markers;biomarker identification;Cancer Biology;cancer diagnosis;cancer imaging;Cell Differentiation process;Cell Line;Cells;Cessation of life;Chick;chorioallantoic membrane;Classification;Clinical Trials;cohort;Data;Diagnosis;Disease;Distant Metastasis;DNA Repair Pathway;Epidemic;Epidemiologist;epithelial to mesenchymal transition;Event;Exhibits;Genes;Genome;Goals;Grant;Head and Neck Cancer;Health;high risk;HPV negative;HPV oropharyngeal cancer;Human;Human papilloma virus infection;human papilloma virus oncogene;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Image;Image Analysis;Immune;immune cell infiltrate;Immune response;improved;In Vitro;in vivo;in vivo Model;Incidence;Individual;Infection;Invaded;keratinocyte differentiation;Length;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Methods;Michigan;Molecular;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Oncogenic;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;Oxidation-Reduction;Oxidative Phosphorylation;Pathologist;patient subsets;Patient-Focused Outcomes;Patients;Phase II Clinical Trials;PIK3CA gene;Positioning Attribute;predictive marker;Prevalence;Process;Prognosis;prognostic;Protein Isoforms;Protocols documentation;Quality of life;Race;radiation resistance;radiation response;Recurrence;Regimen;Resources;Risk;RNA Splicing;Role;Sampling;Selection for Treatments;sex;Signal Pathway;Site;Slide;Smoking;Survival Rate;Survivors;therapy resistant;transcriptome sequencing;treatment effect;treatment group;Treatment Protocols;treatment response;Treatment-related toxicity;tumor;Tumor Markers;tumor progression;Tumor Subtype;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Universities;vector

PROJECT_TITLE: Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Prevention;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Chemotherapy treatment during cancer treatment can induce cognitive impairments, and often involves environmental influences such as oxidative stress. The manipulation of anti-oxidant molecules in normal brain tissues may impact critical events associated with behavioral performance. The ability to quantify and interrelate measures of neuronal morphology, biochemistry and behavioral performance in animals that overexpress a specific anti-oxidants will provide novel insight about chemotherapy induced cognitive impairment, and may ultimately contribute to the development of strategies or approaches for the management of this serious complication.

PI_NAMEs: ALLEN, ANTINO RECIO (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Aftercare;American;Animal Model;Animals;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Architecture;Behavioral;Biochemistry;Bioenergetics;blood-brain barrier crossing;Brain;Brain Injuries;brain tissue;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cancer diagnosis;Cancer Survivor;cancer therapy;cell injury;Cell Respiration;Cells;Central Nervous System;chemobrain;chemosensitizing agent;chemotherapy;Chemotherapy and/or radiation;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive performance;combat;Complication;Confusion;Cyclophosphamide;cytotoxicity;Development;Diagnosis;Disease;Distress;Doxorubicin;effective therapy;Equilibrium;Event;Functional disorder;functional independence;Genes;Homeostasis;Hydrogen Peroxide;Impaired cognition;Impairment;improved;Individual;Inflammation;Inflammatory Response;Injury;insight;Intervention;Knock-out;Knowledge;Life Experience;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Manganese;Measures;Mediating;Memory impairment;Metabolic;Metastatic breast cancer;mimetics;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;mouse model;National Cancer Institute;Neuroanatomy;Neuronal Differentiation;Neurons;Normal Cell;Normal tissue morphology;novel;Nuclear;Organ;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Oxygen Consumption;Paclitaxel;Pathogenesis;Patients;Performance;Peripheral;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Play;Porphyrins;Predisposition;prevent;Production;Promoter Regions;protective effect;Quality of life;radiation-induced tissue damage;Reactive Oxygen Species;Recording of previous events;Regimen;remediation;Reporting;Research;Research Personnel;Response Elements;Rodent Model;Role;SOD2 gene;Superoxides;Survival Rate;Survivors;Symptoms;Testing;Therapeutic;Time;tumor;Tumor Biology;tumor growth;Tumor Tissue;Up-Regulation;Woman

PROJECT_TITLE: MnBuOE as a Novel Chemosensitizer for Breast Cancer and Neuroprotector


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: PROJECT NARRAVTIVE Sexually transmitted infections (STIs) are highly prevalent in adolescent girls and young women and, in many regions of the world, diagnostic testing is not widely available; therefore, women only receive treatment if they report symptoms. However, the majority of women with an STI do not experience symptoms, resulting in persistent infections that can have serious consequences for reproductive health. In this proposal, we will assess the acceptability of point-of-care STI testing plus expedited partner treatment and its impact on the incidence of common curable STIs among women at risk for STIs and HIV, providing critical information to national policy makers and reducing the burden of STIs in women.

PI_NAMEs: PALANEE, THESLA  (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: acceptability and feasibility;aged;Chlamydia trachomatis;chronic infection;Clinical Trials;Collaborations;comparative;cost;Cost Analysis;cost estimate;Counseling;Dapivirine;Data;Diagnostic tests;Disclosure;Ectopic Pregnancy;Educational workshop;Eligibility Determination;Enrollment;experience;Exposure to;Female Adolescents;follow-up;Fright;Goals;Guidelines;Health Personnel;High Risk Woman;high standard;HIV;HIV-1;implementation evaluation;improved;Incidence;Infection;infection rate;Infertility;interest;Interview;Knowledge;low and middle-income countries;male;Methods;microcosting;Modality;Neisseria gonorrhoeae;neonatal infection;Oral;Outcome;Participant;peer;Pelvic Inflammatory Disease;Persons;Play;point of care;point of care testing;point-of-care diagnostics;Policy Maker;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;Prevention Research;Process;Prospective, cohort study;Public Health;rapid test;Recommendation;Recurrence;Reporting;Reproductive Health;Research;Resources;Risk;Role;Sampling;scale up;screening;sexual and reproductive health;Sexual Partners;Sexually Transmitted Diseases;social;South Africa;South African;standard of care;STI prevention;Sustainable Development;Swab;Symptoms;Syphilis Serodiagnosis;Target Populations;Testing;trial enrollment;Trichomonas vaginalis;uptake;Vagina;Vaginal Ring;Visit;Woman;young woman

PROJECT_TITLE: Integrating Expedited partner STI Therapy During prep Delivery for young women

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The long-term goal of the RCMI Specialized Center, Ola HAWAII, is to improve minority health and reduce health disparities for those communities in Hawaii which suffer disproportionately in health outcomes and healthcare access. In the next five years, the objective of the Center is to lead and advance minority health and health disparities research in Hawaii. Ola HAWAII has assembled an exemplary team to build institutional capacity in basic biomedical, clinical and behavioral research; engage underserved communities; mentor and support a diversified workforce; and enhance core facilities and resources.

PI_NAMEs: HEDGES, JERRIS ROBERT (contact);MOKUAU, NOREEN

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Acceleration;Address;Area;aspirate;base;Basic Science;Behavioral Research;Biomedical Research;Burn injury;Cardiovascular Diseases;Climacteric;Clinical Research;Collaborations;Communities;community collaboration;Community Participation;Core Facility;COVID-19;Diabetes Mellitus;Disparity;Ethnic Population;Evaluation;Faculty;Filipino;Funding;Goals;Hawaii;Hawaiian;healing;Health;health care availability;Health Disparities Research;health disparity;health equity;Health Policy;improve minority health;improved;Inequality;innovation;Institution;institutional capacity;Island;Lead;Letters;Malignant Neoplasms;Measures;medical schools;medically underserved;Mentors;minority health;minority health disparity;Minority-Serving Institution;Names;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;novel strategies;Outcome;Outcomes Research;Pilot Projects;Policies;Policy Developments;Postdoctoral Fellow;Principal Investigator;Process;Productivity;programs;Public Health;racial population;recruit;Reduce health disparities;Research;research facility;Research Personnel;Resource Allocation;Resource Sharing;Resources;Services;Specialized Center;success;Translations;Trust;underserved community;Underserved Population;Universities;Work

PROJECT_TITLE: Ola HAWAII


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed 5-year research plan focuses on ensuring that the PhenX Toolkit continues to meet the evolving needs of the genomics, bioinformatics, and biomedical research communities. This effort will raise awareness of the Toolkit as a valuable resource and also attract additional users to the Toolkit. Widespread adoption of PhenX measures will facilitate cross-study analysis and thus increase the scientific impact of individual studies.

PI_NAMEs: HAMILTON, CAROL MARIE (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Adoption;Area;Awareness;Bioinformatics;Biological Assay;Biomedical Research;biomedical resource;Blood;career;Catalogs;Clinical Research;Collection;Common Data Element;Communities;Consensus;COVID-19;Data;Data Collection;data sharing;database of Genotypes and Phenotypes;Educational Materials;electronic data;Electronic Health Record;Ensure;epidemiology study;Etiology;Exposure to;Fast Healthcare Interoperability Resources;Focus Groups;Funding Opportunities;Genome;Genomics;Goals;Health;Health Status;Human;human disease;improved;Individual;International;interoperability;knowledgebase;Link;Logical Observation Identifiers Names and Codes;Measurement;Measures;medical specialties;National Human Genome Research Institute;National Institute on Minority Health and Health Disparities;Online Systems;Outcome;outreach;Participant;Patient Care;Phenotype;PhenX Toolkit;Process;Protocols documentation;Quality of life;Questionnaires;RADx Underserved Populations;Recommendation;Research;Research Personnel;Researching COVID to Enhance Recovery;Resources;response;Science;Scientist;Site;social health determinants;Strategic vision;Substance abuse problem;Substance Addiction;Time;Translational Research;United States National Institutes of Health;United States National Library of Medicine;Update;working group

PROJECT_TITLE: Establishing the PhenX Toolkit as a Biomedical Knowledgebase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HEDGES, JERRIS ROBERT (contact)

PROJECT_TERMS: Acceleration;Address;Award;Basic Science;Behavioral Research;Biological;Biomedical Research;career development;Centers of Research Excellence;Childhood;Clinical Research;Clinical Trials Network;Collaborations;Communication;community engagement;community partners;Core Facility;Dedications;Development;Doctor's Degree;Education;Evaluation;experience;Extramural Activities;Filipino;Fostering;Funding;Generations;Grant;Hawaii;Health;health determinants;Health Disparities Research;health disparity;Health Occupations;Health Policy;higher education;Home;Human Resources;improve minority health;improved;Information Dissemination;innovation;Institution;institutional capacity;inter-institutional;Intervention;Leadership;Measures;medically underserved;minority health;minority health disparity;minority investigator;Modeling;multi-ethnic;Native Hawaiian or Other Pacific Islander;operation;Outcome;Policy Developments;Process;Productivity;programs;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Resource Allocation;Resource Sharing;Resources;Science;Services;socioeconomics;Specialized Center;Structure;success;System;Talents;Translational Research;Underrepresented Minority;Underrepresented Students;underserved community;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;HIV/AIDS;Nutrition;Physical Activity;Prevention

PI_NAMEs: POLGAR, NOEMI  (contact)

PROJECT_TERMS: Acute;Address;Adipocytes;Adipose tissue;Affect;Biogenesis;Blood Vessels;candidate selection;Cell Line;Cell model;cell type;Cells;Communication;Complex;Development;effective intervention;Ethnic Origin;Exercise;exercise capacity;exercise intervention;exosome;extracellular vesicles;Foundations;glucose metabolism;glucose tolerance;glucose uptake;glycemic control;Guidelines;Hawaii;Health;health disparity;Hepatocyte;High Fat Diet;High Prevalence;Hyperglycemia;improved;In Vitro;in vivo;Injections;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;Investigation;Knock-out;lifestyle intervention;Link;Lipids;Liver;Locales;Measures;Metabolic;Metabolism;miRNA expression profiling;mitochondrial metabolism;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Muscle;Muscle Fibers;Muscle function;muscle metabolism;nanoparticle;nanosized;Native Hawaiian or Other Pacific Islander;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acids;Organ;Outcome;paracrine;Phosphotransferases;Physiological;pre-clinical;preclinical study;Prevalence;Production;Protein Array;protein complex;protein expression;Proteins;Proteomics;Reporting;Research;response;Risk Reduction;RNA;Rodent Model;Role;sedentary;Signal Induction;Signal Transduction;Signaling Molecule;Skeletal Muscle;skeletal muscle metabolism;skeletal tissue;targeted delivery;Testing;Therapeutic;Tissues;tool;trafficking;Training;Transgenic Mice;uptake;Vesicle

PROJECT_TITLE: Exercise, Exosomes, and Metabolic Health in Type-2 Diabetes


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHUNG-DO, JANE   (contact)

PROJECT_TERMS: Acceleration;Aquaculture;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolic risk;Cholesterol;Clinical;Communities;comparison intervention;Consumption;Control Groups;Death Rate;Diabetes Mellitus;disorder risk;Disparity;Disparity population;economic disparity;Economics;Educational Curriculum;Educational process of instructing;efficacy testing;Ethnic Population;experience;Face;Family;Fishes;follow-up;Food;food consumption;food insecurity;Food production;food security;fruits and vegetables;Glycosylated hemoglobin A;Goals;good diet;group intervention;Hand;Hawaii;Hawaiian;health disparity;Health Food;Health Promotion;Healthy Eating;Heart Diseases;Hip region structure;Home;Hydroponics;improved;Indian reservation;Indigenous;Individual;Intervention;Interview;Life Expectancy;Life Style;Living Costs;Measurement;Measures;Methods;Minority;mortality;National Institute on Minority Health and Health Disparities;Native Hawaiian;neighborhood disadvantage;Neighborhoods;Participant;peer;Persons;Pilot Projects;Plants;post intervention;prevent;Prevention strategy;racial population;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Rest;Risk Reduction;Site;System;Technology;Testing;Traditional Medicine;Training;trial design;Underrepresented Populations;Underserved Population;Waiting Lists;Water

PROJECT_TITLE: MALAMA:  Backyard Aquaponics to Promote Healthy Eating and Reduce Cardiometabolic Risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DEVENDRA, GEHAN  (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Anxiety;Biological;Bone Marrow;Bronchoalveolar Lavage Fluid;Bronchoscopy;Case Fatality Rates;Cells;chemokine;Chronic;Clinical;Cohort Studies;comorbidity;Coughing;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 severity;cytokine;Data;Development;Disease;Disease Progression;Dyspnea;Ethnic Origin;experience;Family;Fatigue;Fibrin fragment D;Fibrosis;Filipino;Frequencies;Hawaii;Health Disparities Research;health disparity;Healthcare Systems;hospitalization rates;Housing;Immune;Immunologics;immunopathology;Income;Individual;Infection;Inflammation Mediators;Inflammatory;insight;Longitudinal cohort study;longitudinal design;Low income;Lung;lung repair;Macrophage;Memory Loss;minority health;minority health disparity;Modeling;monocyte;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Natural regeneration;Nature;Outcome;Participant;Pathologic;Patients;persistent symptom;Phenotype;Play;Post-Acute Sequelae of SARS-CoV-2 Infection;Prevalence;Preventive;Process;prospective;psychologic;Psychological Factors;Psychosocial Factor;Pulmonary Fibrosis;Pulmonary function tests;pulmonary symptom;Race;Recording of previous events;Resolution;Respiratory Failure;Respiratory System;response;Role;Severities;Severity of illness;Sleep Disorders;social;social determinants;social factors;Social isolation;Source;Symptoms;Syndrome;Testing;Therapeutic;Therapeutic Intervention

PROJECT_TITLE: Factors Responsible for the Development of Post-Acute Sequelae of Acute COVID Infection (PASC) In Hawaii


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Childhood cancers are caused by genetic mutations inherited at birth or acquired during cancer development. Understanding these mutations is critical for accurate diagnosis and treatment of children and young adults with cancer, but they are currently under-represented in public genetic databases. We will develop procedures and expert panels to fill this gap by performing focused curation of mutations found in childhood cancers.

PI_NAMEs: GRIFFITH, MALACHI ;GRIFFITH, OBI L. (contact);RACA, GORDANA

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: ABL1 gene;accurate diagnosis;actionable mutation;Address;adjudication;Adopted;Affect;Alleles;American Society of Clinical Oncology;anti-cancer research;Area;B-Cell Acute Lymphoblastic Leukemia;Benign;Birth;cancer diagnosis;Cancer Etiology;Catalogs;Child;Childhood;Classification;Clinical;clinical application;clinical decision-making;clinically actionable;clinically relevant;clinically significant;ClinVar;Collaborations;crowdsourcing;Data;data curation;data exchange;data hub;data standards;Databases;Development;Diagnosis;Disease;DNA Sequence Alteration;Environment;Event;experience;Funding;Genes;Genetic;genetic counselor;Genetic Databases;genetic variant;Genome;genome-wide;genomic data;Genomics;Goals;Grant;Guidelines;Human Genetics;Informatics;information display;Inherited;Knowledge;knowledgebase;Laboratories;Link;Los Angeles;Lymphoblastic Leukemia;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Molecular;Molecular Profiling;Mutation;National Institute of Child Health and Human Development;novel;novel strategies;Pathway interactions;Pediatric Hospitals;Pediatric Neoplasm;Phenotype;Philadelphia;Policies;Population;precision oncology;Prediction of Response to Therapy;Procedures;Process;Process Assessment;Professional Organizations;Prognosis;Publications;Registries;repository;Reproducibility;Research Personnel;Resources;response;Somatic Mutation;Testing;Translating;treatment response;tumor;United States National Institutes of Health;Universities;user-friendly;Variant;Washington;working group;young adult

PROJECT_TITLE: Genomic Expert Curation Panels for Pediatric Malignancies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: FOGELGREN, BENJAMIN C. (contact)

PROJECT_TERMS: Address;Affect;base;Behavioral Research;Biomedical Research;Biometry;Businesses;career development;Clinical Research;Collaborations;Communication;Communities;community collaboration;community engagement;Consultations;Core Facility;Data Science;design;Development;Diagnosis;Direct Costs;Discipline;disorder prevention;Effectiveness;effectiveness evaluation;effectiveness research;ethnic minority population;Evaluation Research;experience;Extramural Activities;Faculty;Funding;Grant;Hawaii;Health Disparities Research;health disparity;Histopathology;innovation;Institution;Leadership;Link;Marketing;Mentors;minority health;minority health disparity;Modernization;Needs Assessment;outreach;Pilot Projects;Policies;Procedures;Productivity;programs;Publications;Reduce health disparities;Regulation;Research;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;satisfaction;Science;Scientist;Services;Stream;Structure;success;Technical Expertise;tool;Training;Training and Education;Training Programs;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Research Capacity Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BRAUN, KATHRYN LENZNER (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Behavioral;career;career development;Clinical;cohort;Collaborations;Communities;community engagement;Complement;culturally appropriate intervention;Data Analyses;design;Development;Development Plans;Disparity;disparity reduction;Diverse Workforce;education research;Environment;Ethnic Origin;Evidence based practice;experience;Extramural Activities;Faculty;Filipino;Fostering;Funding;Goals;Grant;Hawaii;Health;Health Disparities Research;health disparity;health equity;health literacy;Health Policy;implementation intervention;improved;Individual;Inequity;innovation;Institutionalization;Intervention;Investments;Lead;Leadership;Learning;Link;Measures;Mentors;Methods;Minority Groups;Monitor;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Persons;Pilot Projects;Policy Maker;Postdoctoral Fellow;Productivity;programs;Qualifying;Race;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Sampling;Science;Secure;Site;skills;socioeconomic disparity;Structure;student mentoring;success;Time Management;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;Work;Writing

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Johns Hopkins BIRCWH program takes advantage of an extraordinary interdisciplinary academic environment to support the career development of promising junior scientists. Research will focus on diseases specific to women, sex /gender differences in disease expression, the social determinants of women's health, and sex /gender disparities. Scholars will develop into independent investigators and leaders in interdisciplinary women's health who improve clinical care for women and identify opportunities to more adequately address biological and social determinants of health.

PI_NAMEs: FORD, DANIEL ERNEST (contact)

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: addiction;Area;Attention;Cancer Biology;Cardiovascular system;career development;Clinical Research;Collaborations;Competence;Discipline;Discipline of Nursing;Disease;Disparity;experience;Faculty;Foundations;Funding;gender difference;Genetic;Goals;Health;health difference;high risk population;Immunology;improved;innovation;Institution;Interdisciplinary Study;International;Lead;lens;Life Cycle Stages;medical schools;Mentors;Mentorship;multidisciplinary;Neurosciences;Positioning Attribute;Poverty;programs;Public Health;Qualifying;recruit;Reproductive Biology;Research;Research Personnel;Resources;Secure;sex;Sex Differences;social determinants;Strategic Planning;success;Trauma;Underrepresented Minority;Underrepresented Populations;violence against women;Woman;Women's Health

PROJECT_TITLE: The Johns Hopkins Clinical Research Scholars in Women's Health (BIRCWH)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TSARK, JOANN UMILANI (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Back;Basic Science;Behavioral Research;Biomedical Research;Cardiac health;Clinical Research;Communities;community building;community collaboration;community engaged research;community engagement;community involvement;Community Networks;community organizations;Community Participation;community partners;community research;Consultations;Development;distrust;Equity;Event;Evidence based intervention;experience;Filipino;follow-up;Funding;Goals;Hawaii;Health;Health Disparities Research;health disparity;Heart;improve minority health;Individual;Infrastructure;Island;Lived experience;Malignant Neoplasms;member;Mentors;National Institute on Minority Health and Health Disparities;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Needs Assessment;online course;Outcome;Outcomes Research;Participant;Persons;Pilot Projects;Policies;policy implication;programs;Public Health;Published Comment;Reduce health disparities;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Research Support;Resource Sharing;Role;Training;Trust;Underrepresented Populations;underserved community;Underserved Population;Universities;Voice;vulnerable community

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE A major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Technological advances have allowed researchers to begin to optically measure and modulate neural activity, and while a great deal of scientific and technical progress has been made, there is still much to learn concerning complex neural function, especially within the context of natural behavior. Here, we will fill this gap by developing open-source, head-mounted miniature microscopes with closed-loop spatiotemporal illumination capabilities for large-scale, real-time, patterned photo-stimulation and improved neural imaging in freely behaving animals.

PI_NAMEs: AHARONI, DANIEL  (contact);BLAIR, HUGH T;GOLSHANI, PEYMAN

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Acceleration;Adoption;Animal Experiments;Animals;Area;Automobile Driving;awake;Behavior;Behavior Control;Behavioral;Brain;Cells;Communities;Complex;Data;design;design,build,test;Detection;detection platform;Development;Devices;Educational workshop;Equipment;Event;experience;experimental study;Feedback;Foundations;Generations;Goals;Grain;Head;Hippocampus;Image;image processing;improved;in vivo evaluation;innovation;Investigation;Knowledge;Learning;Light;Lighting;Link;Measures;Memory;Methodology;Microscope;Mus;neural;neural circuit;neural network;neurobehavioral;neuroimaging;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;novel;Nucleus Accumbens;online resource;open source;open source tool;Operative Surgical Procedures;Optics;Pattern;Persons;Process;process optimization;Protocols documentation;prototype;Rattus;Reading;Research Personnel;Role;Sampling;Site;Slice;Social Interaction;Source Code;spatiotemporal;Structure;System;Techniques;Technology;Testing;Time;tool;Training;wiki;Work;Writing

PROJECT_TITLE: Closed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This innovative proposal builds on a novel hypothesis that neighborhood characteristics can contribute to substance use disorders among urban youth of color. Using geospatial analysis and machine learning methods, this study will have a high impact on aiding prevention scientists to better predict and prevent substance use disorders among urban youth by identifying place-based factors. This study will also serve as a guide for addiction researchers on how to work collaboratively with community members to avoid racial bias in predictive algorithms and develop sustainable solutions that will serve communities in an equitable way.

PI_NAMEs: OPARA, IJEOMA  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: addiction;adolescent substance use;Asthma;Award;Behavior;behavior change;Black race;Characteristics;children of color;Cities;Communities;community based participatory research;community engagement;Complex;Data;Data Set;Development;Epidemic;Equation;Equity;ethnic minority;Health;health equity;Hispanic;Individual;innovation;Learning;Machine Learning;machine learning method;marginalization;member;Methods;model development;National Institute of Drug Abuse;Neighborhoods;New Jersey;novel;Oranges;Outcome;prediction algorithm;Prevention;Prevention Research;Process;protective factors;racial bias;Racial Equity;racial minority population;Reduce health disparities;Research Design;Research Personnel;Resources;respiratory;Risk;Risk Factors;Role;Scientist;social health determinants;Statistical Methods;Statistical Study;substance misuse prevention;substance use;Substance Use Disorder;substance use prevention;System;Urban Community;Work;Youth

PROJECT_TITLE: Integrating Community Based Participatory Research and Machine Learning Methods to Predict Youth Substance Use Disorders for Urban Cities in New Jersey


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Cognitive and emotional health is critical for independent living and quality of life. Using decades of multi-domain longitudinal data, the proposed project will investigate risk and protective factors that can inform interventions and treatments to prevent or reduce cognitive declines, emotional impairments, and dementia. MIDUS is unique for its emphasis on the interplay of cognitive, emotional, biological, and brain health as well as its capacity to illuminate how racial and socioeconomic disparities can contribute to AD/ADRD risk.

PI_NAMEs: JOHNSON, STERLING C;LACHMAN, MARGIE E;RYFF, CAROL D. (contact);SCHAEFER, STACEY M

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Acute;Adult;Affective;affective neuroscience;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid imaging;apolipoprotein E-4;Atrophic;Axon;Behavioral;Biological;Biological Assay;Biological Markers;biomarker identification;biopsychosocial;Blood Vessels;Brain;brain health;Buffers;burden of illness;Cardiovascular Diseases;Chronic;Classification;Clinical assessments;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive interview;cognitive testing;Collaborations;Collection;COVID-19 pandemic;Data;Dementia;dementia risk;Dendrites;Development;Discrimination;Disease;Disease Outcome;Distal;Emotional;Emotions;Event;executive function;Exhibits;Family;Functional Magnetic Resonance Imaging;genetic risk factor;Health;Image;Impaired cognition;Impairment;Independent Living;Individual;insight;Intervention;Knowledge;Life;Life Experience;lifestyle factors;Light;Link;longitudinal analysis;Magnetic Resonance Imaging;Measures;Memory;Molecular;multimodal neuroimaging;multimodality;Nerve Degeneration;neurofilament;neuroimaging;Neuropathy;Neuropsychology;Neurosciences;Neurotic Disorders;neurovascular;novel;Participant;Pathway interactions;Patient Self-Report;peer;perceived discrimination;Perfusion;Persons;Plasma;Positron-Emission Tomography;prevent;Prevention;Process;protective factors;psychologic;Psychophysiology;psychosocial;psychosocial resources;Quality of life;racial disparity;Recording of previous events;Recovery;resilience;Resources;response;Risk;Risk Factors;Risk Marker;Sampling;Science;social;socioeconomic disparity;Speed;stem;Stimulus;Stress;symptomatology;Symptoms;tau Proteins;Telephone Interviews;Testing;therapy development;Time;Tissues;trend;Vascular Diseases;white matter;Work

PROJECT_TITLE: Integrative Pathways to Cognitive, Affective, and Brain Health


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Precision Medicine;Rehabilitation;Serious Mental Illness

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chronic pain is a highly prevalent and costly condition in the United States and a major cause for disability worldwide. Chronic pain is still a clinical diagnosis not based on objective and quantitative measures, which results in a large variability in patients’ classification often even under the same condition and hampers clinical care and scientific research. By drawing a parallel between chronic mental illness and chronic pain, this proposal aims to study the validity of quantitative language processing and audio-visual data analysis in discriminating between different types of chronic pain patients and in predicting response to treatment to derive quantitative and reliable biomarkers for chronic pain.

PI_NAMEs: GEHA, PAUL  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Absence of pain sensation;Acoustics;Adult;Affective;Affective Symptoms;Analgesics;Anxiety;Area Under Curve;Behavior;behavior observation;Biological Markers;Brain;Brain imaging;Cellular Phone;Chronic;Chronic disabling pain;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Classification;Clinic;Clinical;clinical care;clinical diagnosis;clinical pain;clinical practice;Clinical Trials;clinically significant;comorbid depression;cost;Data;Data Analyses;Depressed mood;Development;Diabetes Mellitus;Diagnosis;diagnostic criteria;disability;Disease;drug misuse;effective therapy;Emotional;evidence base;experience;Facial Expression;Friends;Functional disorder;Gestures;Glucose;Heterogeneity;high risk population;Home;improved;individual patient;innovation;Interview;Investigation;Language;language processing;large scale data;Linguistics;Location;Low Back Pain;Machine Learning;machine learning model;Major Depressive Disorder;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Methods;Monitor;Mood Disorders;Moods;Musculoskeletal;natural language;Natural Language Processing;negative affect;neuromechanism;Neurostimulation procedures of spinal cord tissue;novel;novel strategies;Outcome;Pain;Pain intensity;pain patient;Pain Research;Patient Care;patient population;patient response;Patient Self-Report;patient subsets;Patients;Pattern;personalized diagnostics;Phenotype;phenotypic biomarker;Placebos;pre-clinical research;predicting response;Prediction of Response to Therapy;provider communication;Psychoses;Radiculopathy;Reporting;Research;Research Personnel;Research Project Grants;research study;responders and non-responders;response;Role;Sample Size;Schizophrenia;Semantics;Sensory;severe mental illness;Speech;Structure;Symptoms;Syndrome;syntax;Testing;Therapeutic Intervention;tool;Translating;Treatment Failure;treatment response;United States;Video Recording;Visual;Voice

PROJECT_TITLE: Quantitative Language and Facial Expression Phenotyping of Chronic Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Children and adults with acute leukemias have dismal outcomes with current therapy. The planned research project is relevant to public health because the elucidation of oncogenic transcription factor function and development of effective therapeutic strategies will lead to improved therapies for patients. The proposed research is highly relevant to the NIH mission and the urgent unmet need of understanding of molecular mechanisms of aberrant cancer gene control, thereby elucidating fundamental causes and developing improved treatments of human cancer.

PI_NAMEs: KENTSIS, ALEX  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acetylation;Acute leukemia;Acute Myelocytic Leukemia;Adult;antileukemic activity;Apoptosis;Benchmarking;Binding;Biology;Cell Differentiation process;cell growth;Cell Physiology;Cell Survival;Cells;Chemoresistance;chemotherapy;Child;clinical care;clinically relevant;cohort;Combination Drug Therapy;Communication;Complex;Dependence;design;Development;Disease;DNMT3a;effective therapy;Engineering;Epigenetic Process;Exhibits;Functional disorder;functional genomics;Fusion Oncogene Proteins;Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Genetic Markers;Genetic Transcription;Genomics;Goals;high risk;Human;improved;in vivo;inhibitor;innovation;insight;Knowledge;Lead;leukemia;leukemia relapse;leukemia treatment;Leukemic Cell;Link;loss of function mutation;Malignant Neoplasms;Mission;MLL gene;Molecular;molecular subtypes;molecular targeted therapies;mouse model;Nature;novel;Oncogenes;Oncogenic;Outcome;Patient Care;Patients;Peptides;peptidomimetics;pharmacologic;pre-clinical;preclinical study;Productivity;prospective;Proteomics;Public Health;Refractory;refractory cancer;Research;Research Project Grants;Resistance;restoration;Signal Transduction;small molecule inhibitor;Stem cell transplant;Techniques;Technology;Testing;Therapeutic;therapeutic target;therapeutically effective;transcription factor;Translating;Treatment Efficacy;treatment strategy;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: ABERRANT SIGNALING IN ACUTE MYELOID LEUKEMIA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: The care of future generations depends crucially on training the next generation of innovators in the clinical sciences. We propose a mentored training grant at the McGovern Medical School at UT Health for residents in neurology and neurosurgery that will attract the best and brightest and create the next generation of leaders in academic clinical neurosciences.

PI_NAMEs: LHATOO, SAMDEN ;TANDON, NITIN  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Academic support;Advisory Committees;Anatomy;Area;Basic Science;candidate identification;career;career development;Caring;Cities;Clinical;clinical care;Clinical Research;Clinical Sciences;Communities;Country;Dedications;design;Destinations;Development;Diagnosis;Education;Education Projects;education research;Educational Curriculum;Elements;Ensure;Experimental Designs;Faculty;Feedback;Financial Support;Fostering;Funding;Future;Future Generations;Goals;Grant;Health;Health Sciences;Heart;Infrastructure;innovation;insight;Institution;interest;Investments;K-Series Research Career Programs;Leadership;Location;Medical;Medical center;medical schools;Mentors;Mentorship;Mission;Neurobiology;Neurologic;Neurology;Neurosciences;neurosurgery;next generation;novel;Participant;Population;Positioning Attribute;Process;Productivity;programs;Publications;Race;racial diversity;recruit;Research;Research Personnel;Research Training;Residencies;Resources;Scientist;social;Spottings;Structure;success;Texas;Time;Training;training opportunity;Training Programs;translational neuroscience;Translational Research;United States National Institutes of Health;Universities;Vision;Work;Writing;young man;young woman

PROJECT_TITLE: Research Training for Neurosurgery and Neurology Residents & Fellows


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Physical Activity;Prevention;Prostate Cancer;Urologic Diseases;Women's Health Research

PHR: PUBLIC HEALTH STATEMENT In this grant, we will investigate, for the first time, the antitumor effects of exercise on minimally residual disease in patients with high-risk with primary breast, colorectal, or prostate cancer. As such, if successful, the findings of this study could benefit hundred of thousands of patients with or at risk of these cancers and therefore have significant public health impact.

PI_NAMEs: DIAZ, LUIS A;JONES, LEE W (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Adherence;Adjuvant;Adjuvant Therapy;Affect;Aftercare;Age;antitumor effect;appropriate dose;Biological;Breast Cancer Model;cancer cell;Cancer Patient;cancer risk;cancer type;Cell Proliferation;Cell Survival;Cells;Characteristics;Chronic;Clinic;Clinical;clinical investigation;cohort;Colorectal Cancer;cost;curative treatments;Data;design;Development;Diagnosis;Disease;Disease Outcome;Dose;drug development;Eligibility Determination;Ensure;Exercise;exercise capacity;exercise intensity;exercise intervention;Exercise Therapy;exercise training;Exhibits;experience;experimental study;Exposure to;falls;Financial cost;follow-up;Future;genetic variant;Grant;Growth Factor;high risk;High-Risk Cancer;Home;Immune;Immunologic Surveillance;improved;Inflammatory;Investigation;Laboratories;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;meetings;Moderate Exercise;Monitor;monocyte;mouse model;Mutation;novel;Observational Study;Oncology;oncology trial;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;peripheral blood;Pharmacodynamics;Phase;Phase Ia Trial;Phenotype;Positive Lymph Node;pre-clinical;prevent;primary endpoint;Primary Neoplasm;programs;prospective;Public Health;Recommendation;recruit;Recurrence;Recurrent disease;Relapse;relapse risk;Residual Neoplasm;Risk;Safety;screening;Solid Neoplasm;Somatotropin;standard of care;Strenuous Exercise;Telemedicine;Testing;Time;Toxic effect;Translating;treadmill;treatment response;tumor;tumor DNA;tumor growth;Walking;Work

PROJECT_TITLE: Exercise as Interception Therapy in Primary High Risk Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Evolution tends to improve or remove a gene that is bad at what it does. A gene that nominally causes cell death often fails to kill cells; yet it is still found across many organisms and actively utilized. Perhaps we mis-understood its true, underlying functions? We refocus its role as a “trial-by-fire” and outline the novel tools and methods we will use to examine the evolutionary benefits that allowed this gene family to thrive and diversify.

PI_NAMEs: MO, GARY CH (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Algorithms;Biochemical;Bioinformatics;Cell Death;cell killing;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Curiosities;Development;Evolution;Family;Fire - disasters;Gene Family;Genes;Image;improved;Inflammatory;Intuition;Methods;Natural regeneration;Near-Death Experience;novel;Organism;Pathway interactions;Phenotype;Play;programs;repaired;Role;side effect;Signal Transduction;tissue injury;tool;tumor growth

PROJECT_TITLE: Pyroptosis is a Trial-by-Fire Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Genetics;Human Genome;Infertility;Nutrition;Pediatric;Pregnancy;Prevention;Rural Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The effects of paternal exposure to non-persistent pesticides on male reproductive health and offspring health remain unclear as well as the potential mechanisms that explain the associations. This proposal seeks to evaluate male pesticide exposure in relation to semen parameters, sperm DNA methylation, mitochondrial DNA biomarkers, pregnancy and perinatal outcomes as well as epigenetic aging. The proposed study will increase our understanding of how men’s non-occupational exposure to pesticides - a relatively understudied area - impacts couples’ and offspring’s health through sperm and elucidate underlying biologic mechanisms.

PI_NAMEs: MINGUEZ ALARCON, LIDIA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: 2,4-Dichlorophenoxyacetic Acid;accelerated epigenetic aging;Acids;Address;Affect;Age;age related biomarkers;age-related disease;aging biomarker;Agriculture;Alzheimer's Disease;Area;Asthma;Biological;Biological Markers;Boston;cancer type;Child;Child Health;Clinic;Clinical;cohort;Cohort Studies;Conceptions;Consumption;Couples;Data;Development;Diabetes Mellitus;dietary;Disease;DNA copy number;DNA Markers;DNA Methylation;Eating;Environment;environmental chemical;Environmental Exposure;Environmental Health;epidemiology study;Epigenetic age;epigenetic aging;Epigenetic Process;epigenome;experience;Exposure to;Female;Female infertility;Fertility;Fertilization;Fertilization in Vitro;Fetal Growth;Fetal Reduction;Food;food quality;fruits and vegetables;Future;General Population;Genomics;Health;Herbicides;High-Risk Pregnancy;Human;hydroxypyridine;implantation;Individual;Infertility;Insecticides;Intake;Knowledge;Length;Leukocytes;Link;Live Birth;Low Birth Weight Infant;male;Male Infertility;Measures;Medical;men;Metabolic;Mitochondria;Mitochondrial DNA;Modification;molecular marker;Morphology;Motility;National Institute of Environmental Health Sciences;Nitrophenol;novel;offspring;Organophosphates;Outcome;Parkinson Disease;Paternal Exposure;Perinatal;perinatal complications;perinatal outcomes;pesticide exposure;Pesticide Residues;Pesticides;Play;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;pregnant;prospective;Prospective cohort;Public Health;Publications;pyrethroid;Regulation;reproductive;Reproductive Health;reproductive system disorder;Research;Route;Sampling;Seminal fluid;Serum;Source;sperm cell;success;surveillance data;Tissues;United States Environmental Protection Agency;urinary;Urine;validation studies;Woman

PROJECT_TITLE: Male pesticide exposure, reproductive health and epigenetics

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Services;Patient Safety;Prevention;Primary Health Care

PHR: PROJECT NARRATIVE Continuous glucose monitoring (CGM) improves glycemic control, reduces hypoglycemia and facilitates personalized care in insulin-requiring type 2 diabetes (T2D) but are vastly underutilized. Multilevel interventions are increasingly recognized as a promising strategy for addressing complex healthcare problems, such as incorporating CGM devices into routine diabetes care. This proposal aims to apply Implementation Science to develop and test an innovative, multilevel intervention to support adoption and retention of CGM for insulin- requiring T2D patients in primary care.

PI_NAMEs: MIZOKAMI-STOUT, KARA R (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Adopted;Adoption;Adult;American;arm;Award;behavior change;Behavioral;behavioral outcome;Blood Glucose;Blood Glucose Self-Monitoring;career;career development;Caring;Chronic Disease;Clinic;Clinical;Complex;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;design;Development;Development Plans;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Effectiveness;Electronic Health Record;Eligibility Determination;Endocrinologist;Environment;Evaluation;evidence base;experience;Fingers;Food;glycemic control;Glycosylated Hemoglobin;Health;Health system;Healthcare;Hypoglycemia;implementation science;improved;Incidence;informant;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance;Intervention;Interview;Investigation;K-Series Research Career Programs;Knowledge;Literature;Maps;Measures;medication compliance;meetings;Mentors;Methods;monitoring device;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outpatients;outreach;Patient Education;Patient Monitoring;patient-level barriers;Patients;personalized care;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;pragmatic trial;prevent;Primary Care;primary care clinic;primary care clinician;primary care setting;primary outcome;Provider;provider-level barriers;psychologic;psychosocial outcome;Quality of life;remote patient monitoring;Research;research and development;Research Personnel;secondary outcome;skills;social health determinants;stakeholder perspectives;Structure;support tools;System;system-level barriers;Technology;Testing;theories;Therapeutic;therapy design;therapy development;Time;Training;uptake

PROJECT_TITLE: Support to Adopt and Retain Technology (StART) CGM: A pilot study to support continuous glucose monitoring in primary care

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lupus;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Our objective is to develop a diverse pool of well-prepared interdisciplinary investigators focused on advancing knowledge about women's health, the influence of sex and gender on health and disease, and the causal underpinnings of inequities in access and health outcomes. The strategic focus of the Vanderbilt-Meharry BIRCWH is to integrate the study of sex/gender differences and disparities in women's health into thriving research programs across the scientific spectrum, to deepen our understanding of sex/gender biology and actualize personalized prevention, diagnostics, and therapeutics for girls and women.

PI_NAMEs: MAJOR, AMY S;VELEZ EDWARDS, DIGNA R (contact)

PROJECT_TERMS: Advisory Committees;Alzheimer's Disease;Area;Asthma;Award;Biology;Biometry;career;career development;Caring;Case Study;Clinical;cohort;Consult;Consultations;cytokine;Data;Dedications;design;Diagnostic;Disadvantaged;DNA;early-career faculty;Educational workshop;Ensure;Environment;Ethnic Origin;Evaluation;Exposure to;Extramural Activities;Funding;Gender;gender difference;Genetic;girls;Gonadal Steroid Hormones;Grant;Health;health difference;Immunologics;Individual;individualized prevention;innovation;Institution;Intensive Care Units;interdisciplinary approach;Interdisciplinary Study;Knowledge;Lead;Libraries;life span;Link;Lupus;Manuscripts;Mentors;Mentorship;Methodology;next generation;Outcome;Pathway interactions;Population;Preparation;Problem Solving;programs;Publications;racial minority;Reproducibility;Research;Research Design;Research Personnel;resilience;Resources;Role;Series;Severities;sex;Sex Differences;Sex Orientation;Site;Structure;Study Section;synergism;T cell differentiation;Therapeutic;Therapeutic Research;tool;Training;Woman;Women's Health;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative: The most recent community needs assessment denoted cancer as the most significant health priority in Nassau and Suffolk Counties and the second most significant in Queens County. Strategies to decrease cancer burden were identified and included increased outreach and leveraging education and wellness programs to all communities; diverse, underserved, and anyone in our catchment area. With our current system in place Northwell Health NCORP can affect change on health outcomes in the community.

PI_NAMEs: VINCIGUERRA, VINCENT P (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Adherence;Affect;Aftercare;anti-cancer research;base;Cancer Burden;cancer care;cancer clinical trial;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;care delivery;Catchment Area;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Community Clinical Oncology Program;Community Healthcare;Community Physician;Community Practice;Continuity of Patient Care;County;Dedications;demographics;Diagnosis;Diagnostic;Economics;Education;effective therapy;evidence base;Evidence based practice;Goals;Health;health equity;Health Personnel;Health Priorities;Health Services;Health system;Healthcare Systems;improved;Knowledge;knowledge translation;Malignant Neoplasms;Measures;medical specialties;Medicine;Minority Recruitment;Mission;multidisciplinary;National Cancer Institute;Needs Assessment;Operative Surgical Procedures;Outcome;outreach;palliation;Patient Recruitments;Patient-Focused Outcomes;Patients;performance site;Physicians;Population;Prevention;Primary Care;programs;Quality of life;Reduce health disparities;Research;screening;Services;Site;social;System;Techniques;Technology;Underrepresented Populations;Underserved Population;Wellness Program;Woman;Work

PROJECT_TITLE: Northwell Health NCORP


NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PHR: PROJECT NARRATIVE Trauma is the leading cause of mortality in the US in people under the age of 45 and is predicted to be one of the top contributors to the burden of global disease in this decade. This project aims to understand the early immune response and identify immune-based markers of severe burn injury, one of the most common traumatic injuries worldwide. We will focus on neutrophils as the most abundant white blood cell and the first responders in the human immune defense system to injuries.

PI_NAMEs: DINH, HUY QUANG (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Age;analysis pipeline;Anti-Inflammatory Agents;Back;Behavior;Bioinformatics;Biology;Burn injury;burn model;cell type;Cells;Clinical;Communities;Data;Disease;Environment;Equilibrium;first responder;Flow Cytometry;Genetic Transcription;genomic data;Goals;Heterogeneity;high dimensionality;Human;Image;Immune;Immune response;in vivo;Infection;Inflammation;Injury;innovation;interdisciplinary approach;Leukocytes;method development;Methods;migration;model organism;Modeling;Molecular;mortality;mouse model;multimodality;neutrophil;novel;Organ failure;Outcome;Pathologic;Pathway interactions;Patients;Persons;Phenotype;Play;pre-clinical;prevent;Process;programs;Research;response;Role;Sampling;severe burns;Shock;single cell genomics;single cell technology;Site;System;Time;Tissues;transcriptome;Trauma;Traumatic injury;Validation;wound healing;Zebrafish

PROJECT_TITLE: Neutrophil heterogeneity and plasticity in wound healing

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE At present, diseases of the brain are the leading cause of disabilities and, due to longer lifespans and an increasing elderly population, these diseases are expected to become the dominant cause of death in the next 10-20 years, exceeding cancer and heart diseases. To meet this critical need, we are developing a innovative ultrahigh-performance brain positron emission tomography (PET) detector modules that will overcome current technological shortcomings and will provide advanced tools to accelerate research on fundamental mechanisms of brain maladies, and ultimately provide a valuable clinical diagnostic device. This proposed research is relevant to both public health and the NIH's mission pertaining to the development of fundamental knowledge for improving the diagnosis, staging, and treatment of brain diseases and mental illnesses. 1

PI_NAMEs: THOMPSON, MICHAEL O (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Aging;aging population;Algorithms;Alzheimer's Disease;Brain;Brain Diseases;Brain imaging;brain metabolism;brain research;Calibration;Cause of Death;Cerebrovascular Disorders;Childhood;Clinical;clinical diagnostics;Clinical Research;Compton radiation;convolutional neural network;cost;cost effective;Dedications;Dementia;design;detector;Development;Devices;Diagnosis;Diagnostic Equipment;Diameter;disability;Disease;Elderly;Event;extend lifespan;Face;Foundations;Future;Goals;Healthcare Systems;Heart Diseases;high standard;Image;imager;imaging modality;improved;in vivo;innovation;Knowledge;life span;Longitudinal Studies;Malignant Neoplasms;Mental disorders;Metals;Mission;Molecular;molecular imaging;neural network algorithm;neurochemistry;neuropsychiatry;Neurotransmitters;next generation;novel;Outcome;Patients;Performance;Photons;Play;Population;Positron-Emission Tomography;Prevalence;prevent;Price;prototype;Public Health;quantitative imaging;Radiation Dose Unit;radiotracer;receptor;Recovery;Research;Resolution;response;Role;scale up;Scanning;screening;Shapes;simulation;Societies;Staging;standard of care;Structure;System;Technology;temporal measurement;Testing;Thinness;Time;tool;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Advanced thin-slab TOF-PET detector module for next generation of brain PET

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Duke University, a major research university, and North Carolina Central University, a historic black university, both in Durham, NC partner for this career development program in women’s health research. Three selected junior faculty members from these two institutions will receive formal mentoring and training to conduct interdisciplinary research relevant to women’s health across the lifespan emphasizing health disparities and the effects that sex and gender have on health. These well trained scientists will be the future champions for improving women’s health nationwide and globally.

PI_NAMEs: AMUNDSEN, CINDY  (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Behavioral;career;career development;Career Mobility;Clinical;Clinical Services;Collaborations;Discipline;Evaluation;experience;Faculty;Fostering;Foundations;Funding;Future;Gender;gender difference;Goals;Grant;hands on research;Health Disparities Research;health disparity;Health Services Research;Historically Black Colleges and Universities;human disease;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Journals;Lead;Leadership;Learning;life span;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Monitor;North Carolina;Peer Review;Positioning Attribute;programs;Publishing;recruit;Research;Research Institute;Research Personnel;Science;Scientist;senior faculty;sex;skills;social science research;Structure;success;synergism;Time;Training;Underrepresented Populations;Universities;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health (K12)


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cellular function requires the capacity to maintain physiological protein compositions and respond to environmental stimuli. The proposed project will apply large-scale mass spectrometry and proteomics technologies to examine post-transcriptional mechanisms that regulate protein composition and synthesis in mammalian tissues as well as human cell culture models. The results will advance current understanding of how tissues and organisms mount successful responses to oxidative stressors or lose resilience and develop diseases.

PI_NAMEs: LAM, MAGGIE  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Age;aged;Aging;Alternative Splicing;Area;Atlases;Biochemical;Biological;biological adaptation to stress;Cell Culture Techniques;Cell Physiology;Cells;Cellular Stress;cellular targeting;Chemicals;Code;crosslink;Data;Data Set;design;differential expression;Disease;Doxorubicin;Exons;experimental study;Gene Expression;Genes;Goals;Human;Hydrogen Peroxide;In Vitro;in vivo;Individual;innovation;insight;Intervention;Knowledge;Lesion;Link;Locales;Mass Spectrum Analysis;Messenger RNA;method development;Methods;Modeling;Multiomic Data;multiple omics;novel;Organism;Output;Oxidative Stress;Paraquat;Phase;Physiological;Physiology;Play;Post-Transcriptional Regulation;posttranscriptional;Protein Biosynthesis;protein crosslink;Protein Dynamics;protein function;Protein Isoforms;Proteins;Proteome;Proteomics;proteostasis;Regulation;resilience;response;Ribosomes;RNA;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;senescence;Shapes;Spatial Distribution;spatiotemporal;Stable Isotope Labeling;Stimulus;stoichiometry;Stress;stress granule;stress resilience;stressor;Structure;System;Techniques;Technology;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;Translating;Translations;Work

PROJECT_TITLE: Post-transcriptional regulations of proteomes in stress and senescence

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Rehabilitation;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Alcohol use typically begins during adolescence and prevalence rates for alcohol use disorder (AUD) peak before age 21. Yet, despite clinical demand, AUD treatments for youth rely on psychosocial interventions that yield only modest benefits at best. This K24 renewal will provide the candidate with protected time to mentor promising early-career scientists in patient-oriented research in alcohol science and conduct an innovative research project focused on leveraging digital health to improve access to evidence-based interventions.

PI_NAMEs: MIRANDA, ROBERT  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: 21 year old;acceptability and feasibility;addiction;Address;Adolescence;Adolescent;adolescent alcohol and drug use;adolescent alcohol misuse;adolescent alcohol treatment;adolescents with alcohol use disorders;Affect;Aftercare;Age;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol use disorder;Alcohols;American;Area;binge drinking;Black race;career;Caring;Cellular Phone;Clinical;Clinical Investigator;Clinical Trials;Cognitive Therapy;Collection;Communities;Complex;computer science;Computers;critical period;Data;design;Development;digital;digital health;digital intervention;direct patient care;drinking;drinking behavior;E-learning;Ecological momentary assessment;Educational Intervention;Educational process of instructing;Electronics;emerging adulthood;Enrollment;evidence base;Evidence based intervention;Evidence based treatment;feasibility testing;Frequencies;Funding;Goals;Growth;Habits;Health;Health Services Accessibility;Health Technology;Heavy Drinking;Hispanic;Human;Improve Access;improved;innovation;Intervention;Investigational Therapies;Laboratory Research;Learning;Learning Skill;Life;Measures;Mediating;medical specialties;meetings;Mentors;Meta-Analysis;Methods;Modality;Motivation;novel;Outcome;Outpatients;pandemic disease;Pathogenesis;patient engagement;patient oriented research;Persons;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;preference;Prevalence;Process;Productivity;programs;psychosocial;Randomized;real world application;reduced alcohol use;Research;Research Personnel;Research Project Grants;Resources;response;responsible research conduct;satisfaction;Schools;Science;Scientist;Self Management;Services;Severities;skill acquisition;skills;skills training;social;standard care;Substance Use Disorder;substance use treatment;Teenagers;Testing;theories;Time;Training;Translating;Translational Research;treatment as usual;treatment effect;Underserved Population;Vulnerable Populations;Withdrawal;Work;Youth

PROJECT_TITLE: Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative  Infections are a major source of morbidity and mortality in hematopoietic stem cell transplant (HSCT) patients, as they impair hematopoietic stem cell (HSC) self-renewal and engraftment. Here we will investigate how infectious stress modifies the HSC epigenome to promote myeloid differentiation and hinder engraftment. The overall goal is to define mechanisms of preserving long-term HSC function in the setting of inflammatory stress.

PI_NAMEs: TRAN, BRANDON T (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affect;antimicrobial;ATAC-seq;Blood;Bone Marrow;Cell Physiology;Cells;Chromatin;Chronic;chronic infection;Cleavage Under Targets and Release Using Nuclease;Data;Differentiated Gene;Disease;DNA Methylation;DNA Modification Methylases;DNMT3a;Dose;Engraftment;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;exhaustion;experimental study;Exposure to;gene network;Genetic Transcription;Goals;graft failure;hematopoietic engraftment;hematopoietic stem cell differentiation;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;histone modification;Histones;Histopathology;Immune;immune function;Immune response;Immunologic Stimulation;Impairment;improved;improved outcome;in vivo;Individual;Infection;Infection prevention;Inflammation;Inflammatory;insight;Interferon Type II;Knock-out;Laboratory Finding;Macrophage;Measures;Mediating;Modeling;Modification;Morbidity - disease rate;mortality;Multipotent Stem Cells;Mus;Mycobacterium avium;Mycobacterium avium-intracellulare Infection;Myelogenous;Myeloid Cells;Myelosuppression;Organ;Outcome;Pilot Projects;post-transplant;preservation;prevent;Process;Production;promoter;prophylactic;response;self-renewal;Signal Transduction;Source;stem cell differentiation;stem cell exhaustion;stem cell function;Stimulus;Stress;Techniques;therapeutic development;transcriptome sequencing;Transplant Recipients;Transplantation;Work;Writing

PROJECT_TITLE: Epigenetic modification of hematopoietic stem and progenitor cells in inflammation-induced differentiation


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE OVERALL Senescence refers to the loss of cell function with aging and is associated with many chronic diseases of aging, but the mechanisms by which this happens is poorly understood at a molecular level. The proposed project seeks to advance knowledge of the molecular features of senescence through cutting-edge profiling techniques and mouse resources that will complement efforts at the human level to map senescence in human cells and tissues.

PI_NAMEs: KORSTANJE, RONNY ;ROBSON, PAUL ;ROSENTHAL, NADIA A (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;advanced analytics;Age;age-related disease;aged;Aging;aging process;aging related;aging related disease;Aloral;Antibodies;Atlases;bioinformatics resource;Biological;Biological Aging;Biological Markers;Biology;Biology of Aging;Cancer Biology;Cancer Center;Cell Aging;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Chromatin;Chronic Disease;Clinical;clinically relevant;cohort;Collaborations;Communities;Complement;Data;Data Analyses;data integration;data mining;Data Set;data standards;data tools;Databases;Dimensions;Elderly;Ensure;Environment;Face;Funding;Future;Gene Expression;Generations;Genetic;Genetic Variation;Goals;Health;Heart;Human;human tissue;Hypothalamic structure;Image;image reconstruction;improved;Inbreeding;Individual;Informatics;Infrastructure;innovation;interest;Intervention;Kidney;Knowledge;Laboratories;Leadership;life history;life span;lipidomics;Maps;mass spectrometric imaging;member;Metabolic;metabolomics;metadata standards;Methods;Mining;Modality;Modeling;modifiable risk;Molecular;Morphology;mouse genetics;mouse genome;multimodality;multiple omics;Mus;novel;old mice;open data;Pancreas;phenome;Phenotype;Placenta;Positioning Attribute;programs;prospective;protein expression;Proteins;Proteomics;Quality Control;Quantitative Trait Loci;Reproducibility;Research;Resolution;Resources;Risk Factors;RLK5-associated protein phosphatase;Role;Sample Size;Sampling;senescence;senescent cell;senolytics;senomorphic;Shock;Site;Standardization;Syndrome;synergism;Techniques;Technology;technology development;The Jackson Laboratory;Therapeutic;tissue mapping;tissue reconstruction;Tissues;transcriptome sequencing;transcriptomics;Transgenic Mice;translational goal;Variant;Visualization;Work

PROJECT_TITLE: The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)


PI_NAMEs: ROSENTHAL, NADIA A (contact)

PROJECT_TERMS: Animals;Archives;Biological;Biological Assay;Cell Aging;cohort;Collaborations;collaborative environment;Collection;Communication;Creativeness;Data;Data Analyses;Data Collection;Data Coordinating Center;data quality;data sharing;Decision Making;design;Development;Doctor of Philosophy;Ensure;experience;Fostering;Funding;Generations;Goals;Health;Human;human tissue;improved;Infrastructure;Laboratories;Leadership;Logistics;Maps;meetings;member;Monitor;Mus;operation;Phenotype;Pilot Projects;Preparation;programs;Protocols documentation;Recommendation;Reporting;Resource Allocation;Resource Sharing;Resources;Risk Assessment;RLK5-associated protein phosphatase;Sampling;Schedule;senescence;Services;Site;success;synergism;technology development;technology platform;The Jackson Laboratory;tissue mapping;Tissue Sample;Tissues;tool;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-M]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE Urinary tract infections are serious infections that can cause many health complications and death in people with diabetes. Research suggests that cells in the bladder are important for fighting urinary tract infections. By studying how insulin resistance and diabetes impact the antibacterial mechanisms in these bladder cells, we can gain insight into why people with diabetes develop infections and identify new options to treat and prevent them.

PI_NAMEs: SPENCER, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Affect;Agonist;Anatomy;Anti-Bacterial Agents;anti-microbial peptide;antimicrobial;Bacteremia;Bladder;Bladder Urothelium;Caring;Cells;Cessation of life;Clinic;collecting tubule structure;Coupled;Data;Defense Mechanisms;Diabetes Mellitus;Disease;Epithelium;Escherichia coli Infections;experimental study;fighting;Goals;Health;Histone Deacetylase;Histone Deacetylase Inhibitor;Host Defense;Host Defense Mechanism;Human;Hyperglycemia;Immune;Immune response;Impairment;improved;Infection;infection management;Infection prevention;infection risk;Innate Immune Response;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;Kidney;Knowledge;Laboratories;Lower urinary tract;Mediating;microbial;Molecular;mouse model;Mus;Natural Immunity;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Persons;Pharmaceutical Preparations;pharmacologic;PI3K/AKT;PPAR gamma;Prediabetes syndrome;Predisposition;prevent;Prevention strategy;Production;Proteins;Publishing;Receptor Activation;receptor expression;Receptor Signaling;Regenerative response;repaired;Research;response;response to injury;Role;Signal Transduction;Site;Specific qualifier value;Therapeutic;Translations;treatment strategy;Urinary tract;Urinary tract infection;Uropathogenic E. coli;Urothelial Cell;Urothelium;Work

PROJECT_TITLE: Insulin Signaling Activates Urothelial Defenses to Reduce Urinary Tract Infection Susceptibility

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Estrogen;Infectious Diseases;Microbiome;Urologic Diseases;Women's Health Research

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARATIVE The medical burden of urinary tract infection is significant as they directly contribute to 1% of all clinical visits in the United States and, in postmenopausal women, frequently progress into recurrent urinary tract infection, which has significantly limited treatment options beyond long-term antibiotic therapy. The urinary microbiome and vaginal microbiomes have been shown to be interconnected and vaginal Lactobacillus, which are also observed in the urinary tract and are associated with estrogen hormone therapy in postmenopausal women, have been shown to protect against bacterial vaginosis and are associated with reduced recurrent urinary tract infection. In this proposal we aim to identify alternate therapeutic strategies for recurrent urinary tract infection by elucidating the yet unknown mechanisms of how estrogen hormone therapy enriches the urinary tract with putatively protective Lactobacillus.

PI_NAMEs: NEUGENT, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adherence;Affect;Age;Antibiotic Therapy;bacterial genetics;Bacterial Vaginosis;biobank;Biological Assay;Biological Models;Biomedical Research;Bladder;career;Cell Line;Cells;Chemical Models;Clinical;Clinical Research;Coculture Techniques;cohort;Communities;Confocal Microscopy;Data;Deposition;effective therapy;Estradiol;Estrogen decline;Estrogen Therapy;Estrogens;experience;Exposure to;extracellular;Fellowship;Female;Fluorescence;Future;Gastrointestinal tract structure;Genitourinary system;global health;Glucose;glucose metabolism;Glycogen;Glycosaminoglycans;Goals;Hela Cells;Human;Image;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Incidence;Infection;insight;Knowledge;Lactobacillus;Link;Maintenance;Measures;Mediating;Medical;Medical Care Costs;Menopause;Mentors;Metabolic;Metabolism;metagenomic sequencing;Metagenomics;Methods;microbial community;microbiome;microbiota;Modeling;Molecular;Mucous Membrane;Mus;Nutrient;Patients;Polysaccharides;Postmenopause;preservation;Production;programs;Proteoglycan;Recording of previous events;Recurrence;Reporting;Research;restoration;Risk;Role;scaffold;Scientist;Site;Source;Sterility;Structure;Surface;System;Techniques;Testing;Therapeutic;therapeutic target;Thick;Tissues;Training;treatment strategy;United States;urethral microbiota;urinary;Urinary Microbiome;Urinary tract;Urinary tract infection;Urine;urogenital tract;Urothelial Cell;Urothelium;Vagina;vaginal lactobacilli;vaginal microbiome;vaginal microbiota;vaginal mucosa;Visit;whole genome;Woman;Work

PROJECT_TITLE: Mechanistic basis of urinary Lactobacillus enrichment by estrogen hormone therapy


PI_NAMEs: ROBSON, PAUL  (contact)

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Adult;Age;Age Months;Animals;Antibodies;Area;Atlases;Biological;Biological Markers;Biological Models;Biology;Cell Aging;Cell Nucleus;Cell Separation;cell type;Cells;Cellular biology;cohort;Collaborations;Data;Data Analyses;Data Set;Development;Dimensions;Ensure;epigenetic profiling;Epitopes;Fluorescent in Situ Hybridization;Funding;Future;Genes;genetic association;genetic signature;Genetic Variation;Goals;Heart;Hematoxylin and Eosin Staining Method;Human;Hypothalamic structure;Image;imaging platform;Individual;innovation;Intervention;Kidney;Label;Laboratories;Leadership;lipidomics;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;metabolomics;Modeling;Molecular;Molecular Profiling;mouse model;Mus;new technology;old mice;Pancreas;Phenotype;Placenta;Proteomics;Reporter;Research Personnel;Resolution;Resources;response;RLK5-associated protein phosphatase;senescence;senescent cell;senolytics;Shock;single molecule;single nucleus RNA-sequencing;single-cell RNA sequencing;Sorting;Stains;success;Technology;The Jackson Laboratory;Time;tissue mapping;Tissue Microarray;tissue reconstruction;Tissues;Transcript;transcriptome sequencing;transcriptomics

PROJECT_TITLE: The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Biological Analysis Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Narrative  This training program will train doctoral students with quantitative backgrounds to enhance significantly the depth and breadth of interdisciplinary education and training of the next generation of scientific and technical leaders in the important, emerging field of neural interfacing. Trainees of the proposed training program will become future leaders who are the catalysts for neurotechnology innovations that enhance, measure and modulate, and ultimately heal our brain through neural interfaces, and will make important contributions to the diagnosis and management of various brain disorders.

PI_NAMEs: HE, BIN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: neural;Training

PROJECT_TITLE: Integrative Training in Neural Interfacing


NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KORSTANJE, RONNY  (contact)

PROJECT_TERMS: Adipose tissue;Age;aged;Aging;analysis pipeline;Antibodies;Atlases;Benchmarking;Biologic Characteristic;Biological;Biological Markers;Cell Aging;Cell Communication;cell type;Cells;Classification;cohort;Collaborations;Common Data Element;Communities;Computational Biology;Computer Vision Systems;computerized data processing;Data;Data Analyses;Data Analytics;Data Coordinating Center;data integration;data management;data modalities;Data Set;data sharing networks;deep learning;design;Development;Generations;Genetic;Goals;Health;Heart;Human;Hypothalamic structure;Image;imaging Segmentation;Inbreeding;Individual;Kidney;Linear Models;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Metadata;Molecular;Mouse Strains;Mus;novel marker;Nuclear RNA;open source;Pancreas;Pathway Analysis;Placenta;Policies;Population;Preparation;Procedures;Process;process optimization;prospective;Proteomics;Reproducibility;Resolution;response;RLK5-associated protein phosphatase;Sampling;senescence;senescent cell;senolytics;single nucleus RNA-sequencing;single-cell RNA sequencing;Standardization;synergism;Testing;The Jackson Laboratory;tissue mapping;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Visualization

PROJECT_TITLE: The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Data Analysis Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative: With >30 million infected individuals worldwide, an HIV vaccine is urgently needed to slow and eventually eliminate new infections. This proposal seeks to discover and test immunogens and immunization strategies that induce antibody responses that protect against exposure to the enormous diversity of global HIV isolates.

PI_NAMEs: BURTON, DENNIS R. (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antibody Response;Antigens;Biological Assay;Cells;Clinical Trials;Dedications;design;Development;experience;Exposure to;flexibility;Future;Germ Lines;Glycoproteins;Goals;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;Human;Immunoglobulin Somatic Hypermutation;Immunologics;in vivo;Individual;Infection;innovation;manufacture;mouse model;Mucous Membrane;neutralizing antibody;nonhuman primate;novel;operation;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;Procedures;product development;programs;protective efficacy;Regimen;research clinical testing;Research Support;Sampling;Series;Site;Structure;success;Technology;Testing;Translating;translational goal;vaccination strategy;vaccine development;Vaccines;Virion;Virus

PROJECT_TITLE: Consortium for HIV/AIDS Vaccine Development


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Precision Medicine

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: SPANN, MARISA N (contact);TAYLOR, JACQUELYN Y

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Back;Basic Science;career;career development;Clinical and Translational Science Awards;Clinical Investigator;clinical practice;curriculum development;design;Disease;Education;Effectiveness;empowerment;Enrollment;Evolution;experience;externship;Funding;Goals;Health Sciences;implementation science;improved;Information Dissemination;innovation;Learning;Master of Science;Medicine;Methods;Monitor;multidisciplinary;Names;National Center for Advancing Translational Sciences;National Research Service Awards;next generation;novel;Output;patient oriented research;Patients;Postdoctoral Fellow;pre-doctoral;precision medicine;Program Development;programs;recruit;Research;response;Science;skills;Structure;TNFSF15 gene;Training;Training and Education;Training Programs;translational scientist;Universities

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

PHR: Project Narrative Congenital heart disease (CHD) remains the most common type of major congenital malformation and the leading cause of mortality from birth defects with up to one third of patients with complex disease developing heart failure (HF) in the second and third decade of life, despite an intervention. Ventricular assist devices (VAD) in patients with CHD and HF remain underutilized, in part due to the highly variable cardiac anatomy and complex physiology. This study will assess if a 3D printed cardiac model improves visualization of VAD and cannula placement sites in CHD-HF patients as compared to 2D imaging alone and if perioperative factors and patient outcomes improve in CHD-HF patients with use of 3D printed model versus traditional imaging in VAD placement planning.

PI_NAMEs: FAROOQI, KANWAL MAJEED (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;3D Print;Advisory Committees;Affect;Anatomic Models;Anatomy;Award;Cannulas;Cardiac;Cardiac Output;Cardiopulmonary Bypass;career development;Characteristics;Circulation;Clinical;Clinical Data;Collection;Common Ventricle;Complex;Congenital Abnormality;congenital heart abnormality;Control Groups;Data;Data Set;design;Development Plans;Diagnosis;Disease;disorder subtype;Disparity;Early Diagnosis;effective therapy;Enrollment;experience;extend lifespan;Fontan Procedure;Goals;Heart;Heart Abnormalities;Heart failure;Heart Transplantation;heart visualization;high risk;hospital readmission;Hospitals;Image;imaging modality;Imaging Techniques;Imaging technology;implantable device;improved;improved outcome;innovative technologies;Intensive Care;Intervention;Investigation;Learning;Learning Module;left ventricular assist device;Lesion;Life;Life Expectancy;Magnetic Resonance Imaging;malformation;Measures;mechanical circulatory support;Medical;Medical center;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;Operating Rooms;Operative Surgical Procedures;Outcome;Outcome Measure;palliate;Patient Care;Patient imaging;patient oriented research;Patient-Focused Outcomes;Patients;Pediatric cardiology;Pediatrics;Perioperative;Physiology;Population;Positioning Attribute;Postoperative Period;primary outcome;Procedures;professor;prospective;Questionnaires;Randomized;Randomized, Controlled Trials;Reporting;Research;research data dissemination;Research Methodology;Research Personnel;response;Right ventricular structure;routine care;Secondary to;Site;skill acquisition;skills;standard of care;Surgeon;Surveys;Techniques;three-dimensional modeling;Time;tool;Training;two-dimensional;United States National Institutes of Health;Universities;ventricular assist device;Visualization;Waiting Lists;X-Ray Computed Tomography

PROJECT_TITLE: A Study Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment (IMMPACT)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The dysregulation of post-transcriptional modifications, cellular localizations, and associated proteins lead to disease. However, little is known about how these features control the functions of circular RNAs, a recently discovered group of single-stranded RNAs that lack ends. Our investigations will establish a fundamental understanding of RNA biology and will present potential targets for the development of new therapies.

PI_NAMEs: CHEN, YE GRACE (contact)

PROJECT_TITLE: The Regulation of Circular RNA Functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]