ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: HONOLULU

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Elevating dietary assessment through harnessing the capabilities of computers, mobile-based, and image- based technology tools which offer an opportunity to reach a wide audience via cost-effective, convenient, timely, and familiar channels.

PI_NAMEs: DELP, EDWARD J;MCCRORY, MEGAN A;WILKENS, LYNNE R (contact)

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: Age;All of Us Research Program;Area;Assessment tool;Attention;Attenuated;Automation;Behavior;Behavior Therapy;Big Data Methods;Biomarker of Dietary Intake;Characteristics;Chronic Disease;clinical center;Code;Cognition;Communities;comparative;Computers;Consumer Preferences;Controlled Study;cost;cost effective;Data;Data Analytics;Data Collection;data ecosystem;data exchange;data management;Data Security;Data Storage and Retrieval;decision research;design;Devices;Diet;Diet Records;dietary;Dietary Assessment;Dietary intake;Dietitian;Dimensions;Disease;Disease Outcome;Domiciles;doubly-labeled water;Eating;Eating Behavior;Effectiveness;effectiveness evaluation;electronic data;Energy Intake;Engineering;Ensure;Epidemiologist;epidemiology study;evidence base;experience;feeding;Food;Funding;Goals;Health;Hour;Human;Image;Image Analysis;improved;Individual;Ingestion;Intake;intervention program;Interview;Location;Machine Learning;Malignant Neoplasms;Measurement;Measures;medical specialties;men;Methods;Modernization;Monitor;multidisciplinary;novel;nutrition;Obesity;Outcome Study;Paper;Participant;Pattern;Performance;personalized nutrition;Persons;Policies;Population;Population Group;Population Heterogeneity;Precision Health;precision nutrition;preference;Procedures;Process;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;Resources;response;Sample Size;Sampling;scale up;Science;Scientist;Secure;Self Administration;sensor;Site;social;System;Technology;Telephone;Testing;Time;tool;Translational Research;United States National Institutes of Health;Validation;Variant;web-based tool;Woman;Work

PROJECT_TITLE: Traditional and New Dietary Assessment Methods (TANDAM) for Personalized Nutrition


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative and Significance Regulation of genome stability is the hallmark of normal cells, and often deregulated in cancer cells. This project will determine whether the Origin Recognition Complex (ORC), till now believed to be essential for replication initiation, can be bypassed in cancer cells and the mechanism of this bypass. This will be very important for understanding how genome instability occurs in cancers. Non-homologous end-joining (NHEJ) mediated repair of double-strand breaks in DNA is important for the resistance of a cancer cell to radiotherapy and common types of chemotherapy. By implicating a novel family of protein kinases in the signal transduction from DSB to activation of NHEJ, the project will identify new targets for drugs that will increase the sensitivity of cancer cells to radiotherapy or chemotherapy.

PI_NAMEs: DUTTA, ANINDYA  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Affect;ASF1A gene;ATAC-seq;Basal Cell Nevus Syndrome;Binding;Bypass;cancer cell;Cancer cell line;CDC6 gene;Cell Physiology;Cell Proliferation;Cell Survival;cell transformation;Cells;CHEK1 gene;chemotherapy;Chromatin;Complement;Complex;DNA;DNA Double Strand Break;DNA Repair;DNA-PKcs;Double Strand Break Repair;Enhancers;Epigenetic Process;Eukaryota;fly;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genome Stability;Genomic Instability;Grant;helicase;Histones;Human;Individual;inhibitor;Maintenance;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;MCM2 gene;Mediating;Molecular Chaperones;Mus;Mutagens;mutant;new therapeutic target;Nonhomologous DNA End Joining;Normal Cell;novel;Oncogenes;ORC1L gene;origin recognition complex;Pathway interactions;Peptide Initiation Factors;Phosphorylation;Phosphotransferases;Play;Polycomb;Predisposition;Proliferating;protein complex;Protein Family;Protein Kinase;Proteins;Radiation therapy;Reader;recruit;Regulation;repaired;Replication Initiation;Replication Origin;Repression;Resistance;Role;Signal Transduction;Signal Transduction Pathway;Testing;Tissues;transcriptome sequencing;Transformed Cell Line;Yeasts

PROJECT_TITLE: Studies on ORC and double strand DNA break repair

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Unlike neural stem cells in most other regions of the brain which disappear following development, dentate gyrus neural stem cells become quiescent so that they can remain in the adult brain, generating new neurons and contributing an added layer of plasticity to the hippocampal circuit throughout adulthood. The proposed research aims to understand the special developmental process that leads to the establishment of quiescent dentate gyrus neural stem cells and will give us insight into mechanisms that promote long-term neural stem cell maintenance. Future studies may translate the fundamental principles of neural stem cell maintenance derived from this research into therapeutic interventions to enhance neural plasticity and neuroregeneration in the adult brain.

PI_NAMEs: BOND, ALLISON  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;adult neurogenesis;Astrocytes;Basic Science;behavior prediction;Bioinformatics;Biological Process;Brain;Brain region;Candidate Disease Gene;career;career development;Career Mobility;cell behavior;Cell Cycle;Cell Maintenance;Cells;Cellular biology;Communication;Complex;Core Facility;critical period;Data;Data Analyses;Data Set;dentate gyrus;design;Development;Development Plans;developmental neurobiology;Developmental Process;ECM receptor;Embryo;Environment;Exhibits;experimental study;extracellular;Foundations;Funding;Future;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Grant;Hippocampus;Image;in vivo;insight;Integrins;interest;Label;Laboratories;Learning;Life;Long-Term Effects;Maintenance;Maps;Mediating;medical schools;Memory;Mentors;Mentorship;Methods;Molecular;mood regulation;Morphology;Mus;National Institute of Mental Health;Natural regeneration;Neonatal;neonatal period;Nerve Regeneration;nerve stem cell;neurodevelopment;neurogenesis;Neuronal Plasticity;Neurons;Neurosciences;Pathway interactions;Pennsylvania;Play;Population;Positioning Attribute;postnatal;postnatal development;Preparation;professor;programs;Property;prospective;Publications;Radial;Research;research and development;Research Training;Resources;Role;Running;Signal Transduction;single-cell RNA sequencing;skills;stem cell biology;stem cell proliferation;Technical Expertise;Techniques;tenure track;Testing;Therapeutic Intervention;Time;tool;Training;transcriptome;transcriptome sequencing;Translating;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Mechanisms regulating neural stem cell maintenance in the dentate gyrus

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Liver Disease;Lung

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal aims to continue development of a composite shape memory polymer and hydrogel device for use in sealing biopsy tracts that would offer both superior therapeutic and diagnostic benefits over currently available technologies.

PI_NAMEs: MAITLAND, DUNCAN J (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acceleration;Address;age acceleration;aged;Air;American;Animals;biomaterial compatibility;Biopsy;Blood;bone;Breast biopsy;Cancer Center;Cancer Patient;cancer type;Cannulas;chelation;Chemical Structure;Chest;Chronic;Clinical;Complication;contrast imaging;cytotoxicity;design verification;Development;Device Designs;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Disease Progression;Ensure;Equipment;Extravasation;Family suidae;follow-up;Freezing;Frequencies;Gadolinium;Gel;genotoxicity;healing;Healthcare;hemocompatibility;Hemorrhage;Hemothorax;Hour;Hydrogels;Image;Image Enhancement;image guided;imaging modality;Implant;implantable device;implantation;improved;Institution;interest;Intervention;Intubation;Iodine;irritation;Kidney;Liver;liver biopsy;Location;Lung;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;mechanical properties;Medical;member;Memory;Modeling;Monitor;Names;Needles;new technology;Particulate;Patients;pediatric patients;Performance;Physicians;Pneumothorax;Polymers;Polyurethanes;Porosity;Positioning Attribute;pre-clinical;Preclinical Testing;prevent;Principal Investigator;Procedures;programs;Property;Radial;radiologist;Reaction;Recovery;Reporting;Research Contracts;Risk;Roentgen Rays;Safety;Screening for cancer;seal;sealant;secondary endpoint;Services;Shapes;Site;soft tissue;Sterilization;Structure of parenchyma of lung;Swelling;System;Techniques;Technology;Test Result;Testing;Texas;Therapeutic;Time;Tissues;tool;Toxic effect;Translating;tumor;United States;United States Food and Drug Administration;Universities;Visit;Visualization;Work;X-Ray Medical Imaging

PROJECT_TITLE: Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nanotechnology;Prevention

ORG_CITY: RICHARDSON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Narrative  Glutathione (GSH) is the master antioxidant in the body and mainly produced in hepatocytes and depletion of hepatic glutathione has found to strongly correlate with an increased susceptibility to oxidative stress and high risk of many diseases ranging from liver injuries to immunodeficiency, Parkinson’s disease and infectious diseases; however, unlike those conventional serum markers, hepatic glutathione depletion cannot be readily monitored through blood testing. The objective of this proposal is to develop an innovation nanotechnology that empower blood test to be a simple and rapid tool for noninvasive and consecutive monitoring of hepatic GSH depletion. The success will allow this crucial pathophysiological process to be readily monitored in the clinics and serve as an earlier indicator for liver injuries and many other oxidative-stress related diseases.

PI_NAMEs: ZHENG, JIE  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Affect;Affinity;Alkaline Phosphatase;American;Animals;Antioxidants;Aspartate Transaminase;Biochemical;Biological Markers;biomaterial compatibility;Blood;Blood Circulation;Blood Tests;Cell Death;Chemistry;chronic liver disease;chronic liver injury;Clinic;Clinical;clinical practice;Clinical Research;Communicable Diseases;Consumption;Cysteine;Cystine;Diagnosis;Discontinuous Capillary;Disease;Disease Management;disease model;Disease Progression;Dissociation;Dyes;Early Diagnosis;Early Intervention;Early treatment;empowerment;Ensure;Event;Excision;Fluorescence;Foundations;Future;Glutathione;Gold;Hepatic;Hepatocyte;high risk;immunodeficiency;Indocyanine Green;innovation;instrumentation;Kidney;Laboratories;Liver;Liver diseases;liver injury;Measures;Mediating;Modeling;Monitor;Monkeys;mouse model;Mus;nano;nanocluster;nanoGold;nanoprobe;Nanotechnology;Nature;NMR Spectroscopy;non-alcoholic fatty liver disease;non-invasive monitor;nonalcoholic steatohepatitis;novel;nuclear imaging;Organ;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Particle Size;Persons;Pilot Projects;Plasma;pre-clinical research;Predisposition;prevent;Prevention;Process;rapid technique;Renal clearance function;Reporting;Resources;Serum;Serum Markers;Serum Proteins;Signal Transduction;skills;Solid;Specificity;Stream;success;Sulfhydryl Compounds;Surface;Tissues;tool;Transaminases;Translations

PROJECT_TITLE: Noninvasive Monitoring of Hepatic Glutathione Depletion Through Blood Test

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Underserved racial/ethnic minority and low-income individuals with end-stage renal disease (ESRD) have relatively poor access to kidney transplantation, including in early stages of the process to obtain a transplant where the dialysis facility team's assessment of whether a patient is suitable for transplant is pivotal. This application will support an early-stage investigator seeking to become an independent researcher who will investigate these assessment processes, the multi-level (provider, facility, community, and region) factors that shape them, and their impact on patient-level transplant access and disparities. This K01 award will provide mentorship and rich training opportunities to develop new research skills and knowledge, enabling the investigator to conduct groundbreaking research in this area and foster the development and implementation of multi-level interventions that address barriers to transplant for underserved patients with ESRD.

PI_NAMEs: WILK, ADAM STEVEN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Administrator;Advocate;Affect;Anxiety;Area;Assessment tool;black patient;care providers;career;Caring;Characteristics;Clinical;cognitive load;Communities;Complex;complex chronic conditions;Consolidated Framework for Implementation Research;contextual factors;Cross-Sectional Studies;Data;Data Collection;Data Set;Decision Aid;design;Development;Dialysis procedure;disease diagnosis;Disparity;End stage renal failure;Equity;ethnic disparity;ethnic minority;ethnic minority population;Evaluation;experience;Fostering;Future;Goals;Grant;health disparity;Health Services;implementation framework;improved;Incidence;Income;interest;Intervention;Interview;Investigation;Joints;Judgment;K-Series Research Career Programs;Kidney Diseases;Kidney Transplantation;Knowledge;Lead;Link;Low income;Low Income Population;Measurable;Measures;Medical;Mentored Research Scientist Development Award;Mentors;Mentorship;Minor;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Obesity;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;peer;Policies;Policy Maker;Population;pressure;Process;Process Assessment;professor;Protocols documentation;Provider;provider factors;Psychosocial Assessment and Care;Public Health Schools;Qualitative Methods;Quality of life;racial disparity;racial minority;racial minority population;relative cost;Reporting;Research;Research Methodology;Research Personnel;Resources;response;Shapes;skills;socioeconomic disparity;Standardization;Stress;Structure;Surveys;Team Process;Testing;theories;Time;tool;Training;training opportunity;transplant centers;Transplant Recipients;Transplantation;Treatment outcome;Uncertainty;Universities;Validation;Waiting Lists;Weighing patient;Wrestling;Writing

PROJECT_TITLE: Multi-level Factors that Influence Dialysis Facilities' Assessments of Patient Suitability for Transplantation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Tau protein may play a role in regulating protein phosphatase 1 (PP1) in neurons and disease-related modification of tau may cause aberrations in this function leading to toxicity in Alzheimer’s disease and AD- related dementias, however, there are many critical gaps in our knowledge of this potential physiological and pathological mechanism. We will take a multifaceted approach spanning cell culture models (including primary neurons) and in vivo mouse models of normal tau biology, sporadic tauopathy and inherited tauopathy to rigorously study the mechanistic connections between tau and PP1 in multiple cellular pathways. This work will have a significant impact by shedding light on a potentially novel physiological function of tau and the mechanisms driving tau toxicity in sporadic and inherited tauopathies.

PI_NAMEs: KANAAN, NICHOLAS M (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Affinity;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Axon;axonal degeneration;Axonal Transport;Binding;Biological Assay;Biology;Cell Culture Techniques;Cell Fractionation;Data;Disease;FTD with parkinsonism;Functional disorder;Functional impairment;Goals;Health;Healthcare;Human;Impairment;In Situ;in vivo;in vivo Model;Inherited;Injections;insight;knock-down;Knock-in;Knock-in Mouse;Knowledge;Lead;Ligation;Light;Link;Maps;Mass Spectrum Analysis;Mediating;Microtubule-Associated Proteins;Microtubules;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurons;neurotoxicity;novel;Nuclear;Pathologic;Pathology;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Point Mutation;pre-formed fibril;Protein Isoforms;Protein phosphatase;protein protein interaction;Regulation;Role;short hairpin RNA delivery;Signal Pathway;Signal Transduction;squid axon;Structure;Subcellular Fractions;superresolution microscopy;Synapses;tau aggregation;tau function;tau mutation;tau Proteins;Tauopathies;Testing;Thinking;Toxic effect;Viral Vector;Work

PROJECT_TITLE: Tau-Mediated Regulation and Dysregulation of Protein Phosphatase 1

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: The treatment of prostate cancer by radical prostatectomy has long term survival benefits, but in an effort to completely remove the cancer, surgeons often remove nerves adjacent to the prostate which increases postoperative incontinence and impotence. This program will develop new microscopy technology to image prostate surgical specimens during surgery in order to determine if the nerves can be spared without leaving residual cancer. This can increase the rates of nerve sparing prostatectomies, improving postoperative quality of life for prostate cancer patients.

PI_NAMEs: FUJIMOTO, JAMES G (contact)

PROJECT_TERMS: Adoption;Agreement;Apical;Area;arm;Blinded;Cancer Patient;Clinic;Clinical;Color;Consultations;Control Groups;cost;cryostat;Custom;Cytoplasm;Data;Decision Making;Development;Evaluation;Excision;Fluorescence;Formalin;Freezing;Frozen Sections;high resolution imaging;Histology;Hospitals;Human Resources;Image;Imaging Techniques;Impotence;improved;Incontinence;Infrastructure;instrument;Israel;Judgment;Lasers;Lateral;male;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Methods;microscopic imaging;Microscopy;Microtome - medical device;multidisciplinary;Nerve;Nerve-Sparing Prostatectomy;neurovascular;next generation;Notification;novel strategies;Nuclear;Operative Surgical Procedures;Outcome;Paraffin Embedding;Pathologist;Pathology;Patients;Performance;Persons;point of care;Population;Postoperative Care;Postoperative Period;Preparation;primary endpoint;Procedures;programs;Prostate;Prostate Cancer therapy;prostate surgery;Prostatectomy;Protocols documentation;Quality of life;Radical Prostatectomy;Randomized, Controlled Trials;rapid technique;Reading;Recovery;remote assessment;remote technology;Research Personnel;Residual Cancers;Robotics;Scanning;Screening for Prostate Cancer;secondary endpoint;Sex Functioning;Signal Transduction;Site;spared nerve;Specificity;Specimen;Stains;standard of care;Surgeon;Surgical margins;Technology;Time;Tissues;tumor

PROJECT_TITLE: Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Viral mimicry is an emerging therapeutic approach that transcriptionally reactivates endogenous retroviruses and retrotransposons in cancer cells to elicit intracellular antiviral pathways that promote antitumor effects and augment the efficacy of certain cancer therapies, including immunotherapy. However, viral mimicry inducing agents identified to date target both cancer and normal cells, leading to significant side effects for cancer patients. Understanding how the FBXO44/SUV39H1 pathway promotes DNA replication-coupled repetitive element silencing selectively in cancer cells could uncover a targetable epigenetic vulnerability whose inhibition induces viral mimicry to prevent tumor growth and progression and enhance the efficacy of cancer therapeutics.

PI_NAMEs: SPRUCK, CHARLES H. (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Activated Natural Killer Cell;anti-PD1 therapy;antitumor effect;Binding;brca gene;cancer cell;Cancer Patient;cancer therapy;Cell Survival;chemotherapy;chromatin modification;Chromatin Remodeling Factor;Clinical;clinical application;Coupled;cytotoxic;Data;Deacetylase;Development;Disease;DNA biosynthesis;DNA Damage;DNA Methylation;DNA replication fork;Dose Limiting;Endogenous Retroviruses;Epigenetic Process;Exhibits;Gene Silencing;Genetic Transcription;genome integrity;Goals;Growth;Histone Deacetylase;Human;Human Genome;Immunotherapy;in silico;Infiltration;inhibitor;KDM1A gene;Ligands;Malignant Neoplasms;Mediating;Methyltransferase;mimicry;Modification;Molecular;mortality;Mus;mutant;Natural Killer Cells;Neoplasm Metastasis;new therapeutic target;Normal Cell;Nucleosomes;NuRD complex;Organ;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;prevent;Prevention;Proteins;recruit;Regulatory Pathway;Relapse;Repetitive Sequence;replication stress;Research;Resistance;Resolution;response;Retrotransposon;RNA interference screen;Role;side effect;Single Strand Break Repair;Somatic Cell;Stimulator of Interferon Genes;Surface;synergism;Therapeutic;Therapeutic Intervention;Toxic effect;Transcriptional Activation;Transcriptional Silencer Elements;treatment response;tumor;tumor growth;tumor progression;Tumorigenicity;ubiquitin ligase;Viral

PROJECT_TITLE: Targeting the FBXO44/SUV39H1 Pathway in Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Insulin resistance is a risk factor for metabolic syndrome and is often observed in patients suffering from obesity, a major risk factor for cardiovascular disease. Endothelin-1 is increased in patients with obesity and may contribute to insulin resistance. The current proposal will elucidate mechanism by which ET-1 contributes to insulin resistance and will provide preclinical evidence to determine if ET-1 antagonists improve insulin sensitivity and cardiovascular outcomes associated with insulin resistance.

PI_NAMEs: SPEED, JOSHUA S (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Affect;Agonist;American;antagonist;Attenuated;Blood Glucose;blood glucose regulation;bosentan;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Clinical;Data;Diabetes Mellitus;diet-induced obesity;Endothelial Cells;Endothelin A Receptor;Endothelin-1;Fasting;Fatty acid glycerol esters;feeding;gain of function;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;glucose uptake;Health;High Fat Diet;Human;Hypothalamic structure;Hypoxia;hypoxia inducible factor 1;impaired glucose tolerance;Impairment;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Knock-out;Knockout Mice;Laboratories;leptin receptor;lipid metabolism;Lipids;Lipolysis;Liver;LoxP-flanked allele;Mediating;Messenger RNA;Metabolic Diseases;Metabolic syndrome;Modeling;Morbid Obesity;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese patients;Obesity;Outcome;overexpression;Patients;Peptides;Peripheral;pharmacologic;Physiological;Plasma;Population;PPAR gamma;pre-clinical;Prevalence;Production;receptor;Receptor Activation;Receptor Inhibition;response;Risk Factors;Rodent;Rodent Model;Scheme;Signal Pathway;Sleep Apnea Syndromes;System;Techniques;Testing;Thinness;Tissues;Transgenic Mice;Triglycerides;Visceral;western diet

PROJECT_TITLE: Endothelin-1 in Obesity and Insulin Resistance

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Digital mobile-delivered obesity interventions have the potential to impact a wider population than traditional in- person programs, but to date have not resulted in similar weight losses. Newer digital approaches called just- in-time-adaptive interventions (JITAIs) offer adaptive, personalized feedback “when needed” and in “real time,” but there has been no examination of what types of support are needed for weight loss, for whom, and in what behavioral contexts. This study uses a micro-randomized trial to systematically test the effects of behavior change techniques on achievement of daily behavioral goals to optimize message delivery in a comprehensive weight loss JITAI.

PI_NAMEs: VALLE, CARMINA G (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Accelerometer;Achievement;adaptive intervention;Address;Adherence;Adult;Age;Behavior;behavior change;Behavior Therapy;Behavioral;Body mass index;Body Weight Changes;Body Weight decreased;Calories;Characteristics;clinically significant;Collection;contextual factors;cost;Diet;digital;digital health;digital intervention;Eating;efficacious intervention;Electronic Mail;Engineering;evidence base;Experimental Designs;Feedback;Food;Future;Gender;Goals;health data;high risk;improved;Individual;Internet;Intervention;Location;meetings;mobile application;Monitor;Morbidity - disease rate;mortality;multiphase optimization strategy;Nature;Obesity;obesity treatment;Outcome;Overweight;Participant;Patient Self-Report;Persons;pilot trial;Population;programs;public health intervention;Randomized;randomized trial;Recording of previous events;Schedule;Self Assessment;Structure;success;tailored messaging;Techniques;Testing;Text Messaging;Time;tool;trial design;Update;web-based intervention;Weight;Weight Gain;weight loss intervention;wireless;young adult

PROJECT_TITLE: A micro-randomized trial of JITAI messaging to improve adherence to multiple weight loss behaviors in young adults

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE There are approximately 360,000 survivors of preterm birth per year in the US, and these infants have a higher risk of wheeze, asthma, and longer-term lung disease. Methods to assess disease severity and response to treatment have been limited by the difficulty of performing pulmonary function tests among infants. This project will use non-invasive oscillometry to measure lung mechanics among spontaneously breathing healthy term infants and preterm infants with and without lung disease, to improve understanding of developmental lung trajectories and determine the extent to which this novel tool can measure disease severity, quantify response to treatments, and predict longer-term lung health among preterm infants.

PI_NAMEs: TRAVERS, COLM PETER (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Active Learning;Affect;Aftercare;Age;Anesthesia procedures;Area;Asthma;Birth;Breathing;Bronchopulmonary Dysplasia;career;career development;Childhood;Clinical;clinical care;Consumption;Control Groups;design;Development;Development Plans;Devices;Disease;early childhood;Early identification;Early Intervention;Early treatment;Exhalation;experience;extreme prematurity;Forced expiratory volume function;Frequencies;Furosemide;Future;Gestational Age;Goals;Health;high risk;Hospitals;improved;Infant;Infant respiratory distress;innovation;insight;Interruption;Intervention;Intervention Studies;Intervention Trial;Knowledge;Life;Lung;lung development;Lung Diseases;lung health;lung injury;Master of Science;Measures;Mechanics;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Morbidity - disease rate;Multi-Institutional Clinical Trial;Neonatal lung;neonate;novel;Observational Study;Oscillometry;Outcome;Outcomes Research;patient oriented research;Pharmaceutical Preparations;postnatal;Pregnancy;Premature Birth;Premature Infant;Prospective, cohort study;Public Health;pulmonary function;Pulmonary function tests;Records;Reproducibility;Research;research and development;Research Methodology;Resistance;respiratory;respiratory distress syndrome;respiratory morbidity;Risk;risk prediction;Scientist;Sedation procedure;Severity of illness;skills;Survivors;Techniques;Testing;Time;tool;Training;treatment response;ventilation;Vital capacity;Wheezing;Work

PROJECT_TITLE: Non-invasive oscillometry to measure lung mechanics, response to treatments, and predict longer-term pulmonary outcomes among preterm infants: a prospective cohort study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: We study how many types of viruses (SARS-CoV, flu, HIV...) attack cells, and what factors can help or hinder this. We use a technique called Electron Spin Resonance (ESR) to learn how the parts of viruses that do the attacks, called “fusion peptides,” are built, and how proteins in viruses interact with membranes (cell walls), to find possible targets for new drugs to fight the viruses. We also use ESR to study how complexin, an important protein that is related to diseases of the nervous system, interacts with membranes.

PI_NAMEs: FREED, JACK H (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 2019-nCoV;Binding;Biological Process;biophysical techniques;C-terminal;Calorimetry;Cell Wall;Cells;Circular Dichroism;combat;COVID-19 pandemic;Development;Disease;Ebola virus;Electron Spin Resonance Spectroscopy;Emerging Communicable Diseases;Exocytosis;fighting;flu;Goals;HIV;Human;Influenza;Influenza Hemagglutinin;Knowledge;Learning;Membrane;Membrane Fusion;Membrane Proteins;Methodology;Methods;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Nature;Nerve Degeneration;Nervous System Disorder;new therapeutic target;Organism;pathogenic virus;Peptides;Property;Proteins;Role;SARS coronavirus;Severe Acute Respiratory Syndrome;Structure;Techniques;Tertiary Protein Structure;Testing;Titrations;Transmembrane Domain;Viral;Virus;Virus Diseases

PROJECT_TITLE: Advancing our knowledge of viral membrane fusion and of IDP-membrane interactions by ESR


NIH_SPENDING_CATS: Breast Cancer;Cancer;Dietary Supplements;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE: This project investigates how vitamin K affects aggressive breast cancers and whether therapies that modulate this pathway could benefit patient survival. Our studies will determine which forms of vitamin K accumulate in breast tumors and how dietary forms of vitamin K influence tumor progression.

PI_NAMEs: WELSH, JOELLEN  (contact)

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: advanced breast cancer;Adverse effects;Affect;aggressive breast cancer;aldehyde dehydrogenase 1;bone;Breast Cancer Cell;Breast Cancer cell line;Cancer Biology;cancer genomics;carboxylate;carboxylation;cell growth;Cell model;Cell Respiration;Cells;clinically relevant;Coagulation Process;cofactor;Data;Data Set;Diet;dietary;Dimethylallyltranstransferase;Disease;Energy Metabolism;enzyme biosynthesis;Enzymes;feeding;gamma-glutamyl carboxylase;Gene Expression;Generations;Genes;ginsenoside M1;Growth;Histology;Homeostasis;In Vitro;in vivo;insight;Intake;Link;loss of function;Malignant Breast Neoplasm;Mammary gland;Mammary Neoplasms;Mammospheres;Measures;Mediating;Metabolism;migration;Mus;Oncogenes;Oxidoreductase;Pathway interactions;patient subsets;Patients;Phenotype;Physiological;Protein Biosynthesis;protein function;Proteins;Proteomics;response;restoration;Role;screening;stem cell biomarkers;stem cells;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;translational therapeutics;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor growth;tumor progression;Tumor Promotion;Tumor Subtype;uptake;Vitamin K;Vitamin K 1;Vitamin K 2;Woman;Xenograft procedure

PROJECT_TITLE: Vitamin K: Body Pools and Function in Breast Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Synaptic connections are the fundamental building blocks of the brain. Many psychiatric and neurodegenerative diseases involve pathological synaptic function at the cellular and molecular level, but little is known about how synaptic molecules operate in health and in disease. Using a powerful combination of genetics, live animal imaging, biochemistry, and physiology, we propose to study complexin and Munc13, two essential proteins required for proper synapse function.

PI_NAMEs: DITTMAN, JEREMY SAMUEL (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Affinity;Alzheimer's Disease;animal imaging;Animals;autism spectrum disorder;Behavioral;Behavioral Assay;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biology;Biotinylation;Birth;Brain;Bypass;C-terminal;C2 Domain;Caenorhabditis elegans;Cell membrane;Chemicals;Complex;Disease;experimental study;Genetic;Genetic Screening;Goals;GRASP gene;Health;Human;Huntington Disease;Impairment;In Vitro;in vivo;in vivo monitoring;information processing;innovation;insight;Knowledge;Lipid Biochemistry;Mammals;Mediating;Membrane;Mental disorders;Methods;Microcephaly;Molecular;Mus;Mutate;Mutation;Myasthenia;Names;Nervous System;Nervous System Physiology;Neurodegenerative Disorders;neurotransmitter release;Orthologous Gene;Parkinson Disease;Pathologic;Phenotype;Physiology;Play;Point Mutation;Positioning Attribute;presynaptic;prevent;Property;Protein Dynamics;protein function;Protein Isoforms;Proteins;Proteome;quantitative imaging;Recombinants;Regulation;Role;Seizures;Sensory;severe intellectual disability;Shapes;SNAP receptor;Solid;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;System;Techniques;Tertiary Protein Structure;Testing;UNC13B gene

PROJECT_TITLE: Analysis of Synaptic Protein Dynamics

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative The overall goal of this project is to collect and disseminate nationally representative Wave VI data of the National Longitudinal Study of Adolescent to Adult Health (Add Health). The data to be collected and disseminated will be used by thousands of researchers to better understand the social, economic, psychosocial, contextual, and biological determinants of health trajectories and disparities among the cohort of Americans who are approaching midlife. The project has extraordinary potential to contribute to the science of aging, health, and health disparities for decades to come, as the Add Health cohort ages into the middle adult years and beyond.

PI_NAMEs: HUMMER, ROBERT A (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adolescent;Adult;adult obesity;Age;Age Years;Aging;Alcoholic Liver Diseases;Alcohols;Alzheimer's disease related dementia;American;Ancillary Study;Archives;Attention;Behavior;Behavioral;Biological;Biological Assay;Biological Markers;Birth Certificates;Blood;Blood Pressure;Cardiometabolic Disease;Cardiovascular Diseases;career life balance;caregiving;Chronic;Cognitive;cohort;Collection;Communities;Companions;Consent;cost;Country;COVID-19;COVID-19 pandemic;Data;Data Collection;data dissemination;Data Files;Death Certificates;Death Rate;Dimensions;Discrimination;Disease;Disparity;Disparity population;Drug abuse;Drug usage;Economics;Epigenetic Process;ethnic minority;Ethnic Origin;Exhibits;follow-up;Future;Gender;Gene Expression;Genetic Markers;Geography;Goals;Health;health determinants;health disparity;Health Surveys;Healthcare;Heavy Drinking;Home;Hospitalization;innovation;Interview;Intoxication;late life;Life Cycle Stages;Link;Longitudinal Studies;low socioeconomic status;Malignant Neoplasms;Measures;member;Mental Health;microbiome;middle age;mortality;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;Online Systems;Pain;pandemic disease;pandemic impact;Parents;Participant;Persons;Pharmaceutical Preparations;Physical Function;Positioning Attribute;psychosocial;racial health disparity;racial minority;Reporting;Research Personnel;residence;response;Rural;Sampling;Schools;Science;Secure;sexual minority status;social;Social Change;Socioeconomic Status;socioeconomics;Specimen;Stress;Substance abuse problem;Suicide;trend;urban residence;Venous;Visit;Work

PROJECT_TITLE: National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project  Narrative:  The  mechanisms  that  protect  stalled  DNA  replication  forks  and  promote  their  recovery  are crucial for genomic stability and, paradoxically, may also drive chemoresistance in BRCA- deficient tumors. We  will investigate the mechanisms by which the ATR kinase protects stalled replication forks in BRCA- proficient cells,  as  well  as  the  PALB2  and  Ubc13- mediated  pathways  that  promote  fork  protection/recovery  in  BRCA- deficient  cells, shedding new light on how to target fork protection/recovery pathways in cancer therapy.

PI_NAMEs: VINDIGNI, ALESSANDRO  (contact);ZOU, LEE

PROJECT_TERMS: Address;Biological Assay;BRCA deficient;BRCA1 gene;cancer cell;cancer therapy;Cell Line;Cell Physiology;Cells;Chemoresistance;Collection;Cytoprotection;Development;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Electron Microscopy;Excision;experience;Fiber;Genome;genome integrity;Genome Stability;Genomic Instability;Genotoxic Stress;Goals;improved;Laboratories;Link;Mediating;Modeling;Molecular;mutant;novel therapeutic intervention;nuclease;PALB2 gene;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;preservation;prevent;protective factors;protective pathway;Protein Analysis;Proteins;Proteomics;Recovery;recruit;repaired;replication stress;Resected;Resistance;Role;Signal Pathway;Signal Transduction;single molecule;Testing;Therapeutic;tumor;ubiquitin-protein ligase

PROJECT_TITLE: Mechanisms of replication fork protection and recovery

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The present research is aimed at understanding the neural mechanisms of continuous decisions, which have relevant for persistence and self-control. These processes are prominently impaired in addiction. By understanding them, we hope to guide rational development of future treatments, interventions, and prevention.

PI_NAMEs: HAYDEN, BENJAMIN Y (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acceleration;addiction;Animal Model;Anterior;base;Behavior;Behavioral;Behavioral Model;Brain;Categories;Cells;Choices and Control;cingulate cortex;Code;Computers;Decision Making;design;Development;Disease Progression;Dorsal;drug abstinence;Elements;Future;generative models;high dimensionality;Impairment;Implant;improved;insight;interest;Intervention;Joystick;kinematics;Laboratories;large datasets;Linear Models;Macaca;Macaca mulatta;Measures;Mind;Minor;Modeling;Monitor;Movement;Nature;neural;neural circuit;neural correlate;neuromechanism;Neuronal Differentiation;Neurons;Neurosciences;Operative Surgical Procedures;Outcome;Play;Population;Positioning Attribute;Prevention;Process;programs;Research;response;Role;Self-control as a personality trait;Signal Transduction;Structure;Task Performances;Time;tool;usability;virtual

PROJECT_TITLE: NEURONAL BASIS OF PERSISTENCE

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Cancer;Natural Products

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The overarching goal of this research program has been, and will continue to be, the full characterization, structural assignment, and efficient enantioselective total syntheses of architecturally novel, naturally occurring compounds that hold significant potential as new chemotherapeutic agents to be evaluated for clinical intervention in the treatment of cancer. To this end, new synthetic chemistry involving Anion Relay Chemistry, now with Radical Relay Chemistry, will be developed that will have utility not only for this program, but also be of general value to the academic and pharmaceutical communities engaged in Cancer Biology.

PI_NAMEs: SMITH, AMOS B (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Achievement;Acids;Alkaloids;analog;Anions;anti-cancer;anti-tumor agent;Antineoplastic Agents;Architecture;Biological;C-KIT Mutation;Cancer Biology;cancer cell;Cancer Cell Growth;cancer therapy;Catalysis;cell growth;Chemicals;Chemistry;chemotherapeutic agent;Chemotherapy-Oncologic Procedure;Clinical;Collaborations;Color;community engagement;Complement;Complex;Coupling;Cytotoxic agent;design;Development;discodermolide;Doctor of Philosophy;Economics;enantiomer;Evaluation;Exhibits;Family;Family member;flexibility;Goals;Grant;inhibitor;innovation;Intervention;irciniastatin A;Laboratories;Lead;Letters;Malignant Neoplasms;member;Methods;Modeling;Molecular;Natural Compound;Natural Products;neoplastic cell;novel;Oregon;Pharmacologic Substance;Polyenes;polyol;Preparation;Process;Productivity;professor;programs;Progress Reports;Property;Protocols documentation;Publications;Rana;receptor;Research;Research Project Summaries;scaffold;Scheme;spongistatin 1;Structure;Structure-Activity Relationship;Study Section;Synthesis Chemistry;Therapeutic;Time;tool

PROJECT_TITLE: Antitumor Agents:  Structure and Synthesis

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The growing numbers of antimicrobial-resistant pathogens place a significant burden on healthcare systems and have important global economic costs. In this project, we will study thiopeptide antibiotics and develop a predictive model for the identification of potent antimicrobials against ESKAPE pathogens. The results of this study will have a transformative impact on the treatment regimens and will generate new candidates for pre-clinical and clinical studies.

PI_NAMEs: WALCZAK, MACIEJ  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Anabolism;Anti-Bacterial Agents;anti-microbial drug;anti-microbial peptide;Antibiotics;antimicrobial;antimicrobial resistant pathogen;aqueous;Azoles;Bacteremia;bacterial resistance;bactericide;Behavior;Binding;bioactive natural products;Biological;Biology;biophysical analysis;Biophysics;candidate identification;catalyst;Chemicals;clinical investigation;Clinical Research;combat;computer studies;covalent bond;Data;Death Rate;dehydroalanine;design;Development;Discrimination;Disease;Drug Design;drug discovery;economic cost;Elements;Engraftment;Enzymes;ESKAPE pathogens;Evaluation;flexibility;Genes;Goals;Gram-Positive Bacteria;Health;Healthcare Systems;Human;improved;innovation;invention;Investigation;Knowledge;Lead;Light;member;methicillin resistant Staphylococcus aureus;Methods;Microbiology;Modality;Modification;Molecular Target;Multi-Drug Resistance;Mutation;novel;novel therapeutics;Oxazoles;pathogen;Peptides;Pharmaceutical Chemistry;Pharmacology;pre-clinical;preclinical study;predictive modeling;Preparation;Property;Proteins;Research;Resistance;Resistance development;Resistance profile;resistant strain;Ribosomes;Role;Site;small molecule;Solubility;Source;standard care;structural biology;Structure-Activity Relationship;Tail;Testing;Therapeutic;Thiazoles;timeline;tool;translational potential;Treatment Protocols;Validation

PROJECT_TITLE: Synthesis and Chemical Biology of Thiopeptide Antibiotics


ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE (Public health relevance) Proper brain function requires a lot of energy from fuel molecules like glucose, and this energy supply process is highly regulated at the level of individual brain cells and from moment to moment. We know surprisingly little about how this regulation works, and how it goes awry (as it is thought to do) in aging or in neurodegenerative disease. This project will discover the key details of brain cell energy metabolism, including its dynamic response to brain activity and how it varies among different cell types in the brain, and this knowledge will enable future work on disease mechanisms and how they might be corrected by therapeutics.

PI_NAMEs: AGAR, NATHALIE YR;YELLEN, GARY I (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Acute;Address;Aging;Antibodies;Antioxidants;Astrocytes;Behavior;Biosensor;Brain;brain cell;brain health;brain metabolism;brain tissue;Cell Culture Techniques;cell type;Cells;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Data;Disease;Energy Metabolism;Energy Supply;Energy-Generating Resources;Exhibits;experimental study;Fatty Acids;Fire - disasters;flexibility;Foundations;Freezing;Functional disorder;Future;gene product;Glucose;Glutamine;Glycolysis;granule cell;Habits;Heating;Hippocampus;imaging capabilities;imaging modality;in vivo;Individual;inhibitor;inorganic phosphate;Interneurons;Ketone Bodies;knock-down;Knowledge;Label;Learning;Lipids;Maps;mass spectrometric imaging;Measurement;Measures;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;Methods;Microtomy;Mus;NADP;Nerve Degeneration;neural;Neurodegenerative Disorders;neuronal metabolism;Neurons;neuropathology;Oxidants;Oxidation-Reduction;Oxygen;Parvalbumins;Pathway interactions;Pentosephosphate Pathway;pharmacologic;Physiological;Play;Positioning Attribute;Positron-Emission Tomography;preservation;Process;Property;Proteins;public health relevance;Regulation;response;Role;secondary metabolite;sensor;Signal Transduction;Slice;Stable Isotope Labeling;Stress;Technology;Testing;Therapeutic;Time;Tissues;Work

PROJECT_TITLE: Dynamics of Cellular Brain Metabolism Using Mass Spectrometry Imaging

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Emergency Care;Fentanyl Misuse and Addiction;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The purpose of this R01 proposal is to deepen our knowledge of the primary cause of drug overdose deaths in the U.S. today: novel psychoactive synthetic opioids, the majority of which are fentanyl analogues. Using a multicenter registry of patients who present to emergency departments, novel fentanyl analogue overdose will be studied in terms of its epidemiology, analytical confirmation, clinical risk factors, and treatment needs, by a uniquely qualified multidisciplinary team with an extensive track record of collaboration in the field. The overall specific aims of this proposal, are three-fold: (1) molecular identification of novel synthetic fentanyl analogues using state-of-the-art toxicology analytics; (2) determination of treatment requirements such as naloxone, need for critical care and/or mechanical ventilation; and (3) geolocation of regional and temporal overdose trends.

PI_NAMEs: MANINI, ALEX FRANCIS (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: abuse liability;Accident and Emergency department;Address;Admission activity;Adverse effects;Affect;American;analytic epidemiology;Biological;Caring;cathinone;Cessation of life;Characteristics;Chronology;Clinical;Clinical Data;clinical effect;Clinical Management;clinical predictors;clinical risk;Cocaine;cohort;Collaborations;Commerce;cost;Critical Care;Data;data streams;demographics;design;Diagnosis;Disease Outbreaks;Disparity;Drug abuse;drug of abuse;Drug usage;Emergency Care;Emergency Department evaluation;Emergency Department patient;Emergency department visit;Enrollment;Epidemic;Epidemiology;Evaluation;Factor Analysis;fentanyl analog;Forensic Medicine;Health;Heroin;heroin overdose;Hospitals;illicit opioid;improved;Incidence;Individual;Ingestion;Knowledge;Laboratory Markers;Length of Stay;Liquid Chromatography;Mechanical ventilation;Medical;Medical Records;Molecular;Morphine;multidisciplinary;Naloxone;naloxone dosing;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;organ injury;Outcome;Overdose;overdose death;patient registry;Patient Self-Report;Patients;Pattern;Periodicals;Pharmaceutical Preparations;Poison;Population;prescription opioid;Prevalence;Principal Investigator;Property;prospective;Prospective cohort;psychostimulant;Public Health;Qualifying;regional difference;Reporting;Research;Research Personnel;Resource Allocation;Resources;Risk Factors;Sampling;screening;sedative;sex;Standardization;stem;substance use;suicidal;synthetic cannabinoid;synthetic opioid;System;tandem mass spectrometry;Testing;Time;time of flight mass spectrometry;Time trend;Toxicology;trend;trend analysis;Visit

PROJECT_TITLE: Predicting medical consequences of novel fentanyl analog overdose using the Toxicology Investigators Consortium (TOXIC)


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Over 6 million children in the United States have asthma, causing billions of dollars in healthcare expenditures and over 14 million missed school days annually, with most childhood asthma morbidity attributable to medication non-adherence. The proposed research program will evaluate a school-supervised asthma therapy intervention to improve medication adherence in children with poorly controlled asthma that is tailored for real- world settings. This intervention fills an unmet need for the families, pediatric practices and schools that support children with poorly controlled asthma, and has the potential to dramatically improve childhood asthma outcomes.

PI_NAMEs: TRIVEDI, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adherence;adherence rate;Adopted;Adoption;Adrenal Cortex Hormones;Affect;Asthma;Award;career;career development;Child;Child Care;Child Health;Child Support;Childhood;Childhood Asthma;Clinical;Clinical effectiveness;clinical infrastructure;clinical practice;Clinical Trials;Communication;Communities;community clinical linkage;community engaged research;cost;Data;design;Development;Disparity;effectiveness testing;Eligibility Determination;Emergency department visit;Enrollment;Ensure;epidemiology study;experience;Family;Feedback;follow-up;Foundations;Frequencies;Funding;Goals;Health;Health behavior change;Health Expenditures;Health Insurance;Health Sciences;high risk;Hospitalization;implementation barriers;implementation science;improved;informant;Infrastructure;Inhalators;innovation;Intervention;intervention cost;intervention refinement;Interview;Link;Low income;Massachusetts;Master of Public Health;Medical center;medical schools;medication compliance;medication nonadherence;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mid-career faculty;minority children;Modeling;Morbidity - disease rate;multidisciplinary;Nature;Office Nursing;operation;Oral;Outcome;Parents;Patient Recruitments;pediatrician;Pediatrics;Pharmaceutical Preparations;Pharmacists;Pilot Projects;pilot test;Play;Policies;Population;Preventive;Primary Care;Procedures;Process;professor;Program Acceptability;programs;prospective;Protocols documentation;prototype;Public Health;Public Health Schools;Pulmonology;Randomized;Randomized, Controlled Trials;Research;research and development;Research Personnel;research study;Resource-limited setting;Resources;response;Retrospective Studies;Role;routine practice;School Nursing;Schools;Scientist;Site;Spirometry;standard of care;Symptoms;System;Testing;Therapeutic Intervention;Time;Training;treatment as usual;United States;Universities;Work

PROJECT_TITLE: Asthma Link: School Supervised Therapy to Improve Medication Adherence in Children with Poorly Controlled Asthma


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Over 30,000 Americans die from hepatocellular (liver) carcinoma (HCC) every year and current treatments provide no long-term benefit, highlighting the urgent need for new and effective therapies. We have discovered that a protein called BCL6 is required for the growth of HCC tumors, and found that inhibiting BCL6 not only blocks hepatic tumor growth but also enhances the ability of the immune system to eradicate the tumor. The results of the experiments proposed in this application will establish the role of BCL6 in promoting HCC and evaluate novel small molecule inhibitors of BCL6 as a novel HCC therapy.

PI_NAMEs: WAJAPEYEE, NARENDRA  (contact)

PROJECT_TERMS: American;American Cancer Society;analog;BCL6 gene;Biochemical;Biological Assay;BTB/POZ Domain;Carcinoma;Cell Culture Techniques;cell growth;Cell-Mediated Cytolysis;Cessation of life;Characteristics;Cirrhosis;Clinical;Data;design;Development;Diagnosis;Disease;Distal;effective therapy;Environment;Epigenetic Process;epigenetic silencing;Erinaceidae;experimental study;follow-up;Follow-Up Studies;gene repression;Genes;Genetic;genetic corepressor;genome-wide;Growth;growth promoting activity;Hepatic;Hepatocyte;Human;humanized mouse;Immune system;Immunocompetent;Immunocompromised Host;Immunosuppression;improved;inhibitor;innovation;knock-down;Lead;Liver;liver cancer model;Liver Fibrosis;Liver neoplasms;Malignant Epithelial Cell;Mediating;Modeling;Molecular;mouse model;Mus;mutant;Names;Neoplasm Metastasis;new therapeutic target;non-genetic;novel;novel strategies;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;Prevalence;Primary carcinoma of the liver cells;Probability;Property;Proteins;rational design;RNA analysis;Role;Series;small hairpin RNA;small molecule;small molecule inhibitor;Solubility;subcutaneous;Survival Rate;T-Lymphocyte;Testing;Therapeutic;Transcription Repressor;transcriptome;transcriptome sequencing;tumor;tumor eradication;tumor growth;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;United States;Validation;Xenograft procedure;zinc-binding protein

PROJECT_TITLE: Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Aphasia;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety;Rare Diseases;Rehabilitation

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative High-resolution recording at the meso-scale around a depth electrode is arguably one of the most important gaps in the BCI and diagnostic neurosurgery communities. Our approach to recording uses the novel combination of substrate and electrode size to achieve directional sensitivity to isolate local field potentials in the human cortex. This project will conduct an observational study in epilepsy patient volunteers and our translational goal is to eventually treat patients with profound speech dysfunction, first locked-in syndrome and ultimately non-fluent aphasia.

PI_NAMEs: SEYMOUR, JOHN P (contact);TANDON, NITIN

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Acute;Address;Animals;Aphasia;Area;arm;Augmentative and Alternative Communication;barrel cortex;biomaterial compatibility;Brain;brain computer interface;Brain region;Broca Aphasia;Classification;Clinical;Communities;Craniotomy;cranium;Cues;Data;density;design;Development;Devices;Diagnostic;Dimensions;Dysarthria;efficacy testing;Electrocorticogram;Electrodes;Electroencephalography;Enrollment;Epilepsy;Excision;Feasibility Studies;Functional disorder;Future;Goals;Human;Hybrids;Immunity;Implant;implantable device;improved;in vivo;Industry;Information Networks;Institutional Review Boards;Intractable Epilepsy;Language;Language Therapy;Legal patent;Locked-In Syndrome;Longevity;Machine Learning;manufacture;Mechanics;Methods;Microelectrodes;microsystems;minimally invasive;model design;Modeling;Modification;Monitor;neural;Neurobiology;neurophysiology;Neurosciences;neurosurgery;Noise;novel;novel strategies;Observational Study;Operative Surgical Procedures;patient subsets;Patients;Performance;Persons;Physics;Positioning Attribute;Predictive Factor;Production;Radial;recruit;Reporting;Research Personnel;Resolution;response;Robotics;Rodent;Safety;safety study;safety testing;Seizures;Shapes;Sheep;sheep model;Signal Transduction;Source;Speech;Speech Therapy;Surface;Surgeon;System;Technology;Testing;Time;Tissues;tool;translational goal;Trephine hole;usability;Utah;Validation;Vibrissae;virtual;volunteer

PROJECT_TITLE: DIrectional and SCalable (DISC) Microelectrode Array for Speech Decoding

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Nonalcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease in the world, estimated to affect ~25% of the world’s population, and its incidence is projected to continue to grow over the next several decades. Yet, currently available medical therapies for NAFLD are quite limited in number and efficacy. This proposal aims to use a subset of genetically defined NAFLD associated with nuclear envelope defects as a model to gain fundamental insights into NAFLD pathophysiology and provide avenues for novel therapeutic approaches to benefit the millions of people affected by this disease.

PI_NAMEs: BRADY, GRAHAM F. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;biobank;Biochemistry;Bioinformatics;career;career development;Cellular biology;chronic liver disease;Cirrhosis;Clinical;Code;cohort;Communities;Computerized Medical Record;Country;CRISPR/Cas technology;Data;Defect;design;Development;Development Plans;Disease;disease model;Doctor of Philosophy;Drug Screening;early onset;Electron Microscopy;Ensure;env Gene Products;experience;Experimental Models;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;genetic association;Genetic Transcription;genetic variant;Genome;genomic data;Genomics;Goals;Hematoxylin and Eosin Staining Method;Hepatic;Hepatocyte;Hepatology;Heritability;Heterochromatin;HIV-Associated Lipodystrophy Syndrome;Homeostasis;Immunofluorescence Immunologic;improved;in vivo;Incidence;Individual;insight;Jordan;Lamin Type A;Lamins;Link;Lipids;Lipodystrophy;Liver;Liver diseases;liver transplantation;male;Medical;Mentors;Michigan;model organism;Modeling;Mus;mutant;Mutation;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Nuclear Envelope;Nuclear Lamin;Nuclear Lamina;Nuclear Protein;Nuclear Proteins;Pathogenesis;Pathway interactions;patient subsets;Patients;Persons;Physicians;Play;Population;Prevalence;Productivity;Proteins;prototype;Research;Research Personnel;Reverse Transcription;Role;Scientist;Siblings;skill acquisition;skills;Solubility;Stains;Steatohepatitis;success;Susceptibility Gene;System;Techniques;Testing;Therapeutic;Training;transcriptome;transcriptome sequencing;Twin Multiple Birth;United States;Universities;Variant;Zebrafish

PROJECT_TITLE: Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver disease

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative We will study the role of an adaptive stress response (termed “Integrated Stress Response”) and its effector ATF4 in progression and metastasis of malignant melanoma. We will examine how in non-malignant cells the ISR shapes the microenvironment by remodeling blood vessels and the extracellular matrix, and how in turn melanoma cells respond to the microenvironment by using the ISR in combination with well-known pro- tumorigenic mediators to promote invasion and survival during metastatic dissemination. The long-term aim of these studies is to uncover new targets for therapeutic intervention.

PI_NAMEs: GODING, COLIN ;KOUMENIS, CONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Ablation;Adipocytes;Allografting;angiogenesis;Anoikis;Antioxidants;Apoptosis;Apoptotic;Autophagocytosis;Binding;biological adaptation to stress;Blood Vessels;BRAF gene;CAV1 gene;Cells;Coculture Techniques;Collagen;Complex;DNA Sequence Alteration;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Equilibrium;Experimental Neoplasms;Exposure to;Extracellular Matrix;Fatty Acid Desaturases;Fatty Acids;Fibroblasts;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;Heterogeneity;Human;immune cell infiltrate;immune checkpoint blockade;Immunotherapy;Impairment;improved;Inflammation;inhibitor;Integrins;Invaded;Knockout Mice;Link;Lymph;Mediating;Mediator;Melanoma;Melanoma Cell;Melanoma Tumor;Metastatic Neoplasm to the Lung;microphthalmia-associated transcription factor;Modality;Modeling;Monounsaturated Fatty Acids;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Non-Malignant;novel;novel therapeutics;Nuclear;nutrient deprivation;Oncogenes;Oncogenic;Output;Oxygen;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Primary Neoplasm;programs;Proliferating;Publishing;Recovery;Refractory;Reporting;Repression;Resistance;response;Role;Shapes;Signal Pathway;Signal Transduction;Stress;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Translational Repression;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;Tumor-infiltrating immune cells;tumorigenic;uptake;Xenograft procedure

PROJECT_TITLE: The integrated stress response and the microenvironment in melanoma progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-D(02)M]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: The Brain Research Apprenticeships In New York At Columbia (BRAINYAC) program addresses science education disparities found in low-income neighborhoods by providing an authentic mentored research experience for high school students who are from under-served neighborhoods or under-represented minorities in science. We will support these students through preparatory training during the program and opportunities for alumni of the program. In this way we seek to reinforce students’ intent to pursue studies or careers in science, technology, engineering and math (STEM).

PI_NAMEs: SHOHAMY, DAPHNA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Advisory Committees;American;apprenticeship;biological research;Brain;brain research;career;Career Choice;career development;career preparation;Characteristics;college;College Preparation;Communication;Communities;Critical Thinking;Development;disability;Disparity;Educational process of instructing;Educational Status;Educational workshop;Employment Opportunities;Enrollment;Ethnic Origin;Evaluation;Event;experience;field trip;Fostering;Geographic Locations;Goals;hands on research;high school;high school program;High School Student;Hispanic;improved;Incentives;insight;Institution;Knowledge;Laboratories;laboratory experience;Laboratory Study;Longitudinal Studies;Low income;male;Medicine;Mentors;Methods;Minority Groups;Museums;Natural History;Neighborhoods;Nervous System;Neurosciences;New York;New York City;Outcome Measure;parental involvement;Participant;peer coaching;Performance;Population;posters;Poverty;Process;programs;recruit;Research;Research Institute;Resources;Running;Science;science education;science teacher;Science, Technology, Engineering and Mathematics;Scientist;skills;social;STEM field;Structure;Student recruitment;Students;success;summer research;Surveys;Talents;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underserved Population;Universities;Visit;Work;Youth

PROJECT_TITLE: Brain Research Apprenticeships in New York at Columbia (BRAINYAC)


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on finding more effective treatment strategies for pancreatic cancer, one of the most lethal cancers, with a five year survival rate of only ~10%. Pancreatic cancer is extremely aggressive and responds very poorly to existing treatments, this is partially because of the tumor microenvironment that makes tumors more resistant to therapies. Our laboratory studies how this environment induces drug resistance, particularly by enhancing DNA repair, and we have identified novel drivers of resistance that we will target to develop new improved therapies for pancreatic cancer, reducing mortality.

PI_NAMEs: MURANEN, TARU ELIISA (contact)

PROJECT_TERMS: adhesion receptor;Adhesions;Binding;Biology;cancer cell;cancer therapy;Chemoresistance;Chemosensitization;chemotherapy;Combined Modality Therapy;Complex;Data;DNA Damage;DNA Repair;DNA Repair Pathway;DNA replication fork;Drug resistance;ECM receptor;effective therapy;efficacy evaluation;Environment;Event;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Genes;Genetic;Glucocorticoids;Goals;homologous recombination;improved;in vivo Model;innovation;insight;Knock-out;Laboratory Study;Lead;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel;Organoids;Outcome;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;patient derived xenograft model;Patients;Phosphorylation;Phosphotransferases;Proteins;PTK2 gene;Public Health;Radiation therapy;refractory cancer;Reporting;Research;Resistance;Role;Sampling;Serum;Signal Induction;Signal Pathway;Signal Transduction;Stress;Survival Rate;targeted treatment;Testing;therapy outcome;therapy resistant;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Nashville

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Biomedical research holds great promise for finding better treatments and hopefully cures for a range of debilitating and/or fatal diseases, but the innovation and problem solving needed to harness the potential of biomedical research requires a diverse group of individuals who generate new perspectives and more inventive solutions. Given that diversity is critical to biomedical research, it is important to acknowledge that the benefits of diversity are only fully realized through inclusion. The purpose of the IMSD at Vanderbilt is to ensure that students from diverse backgrounds and identities not only acquire the knowledge and skills to pursue successful careers in biomedical research and related areas, but do so in an environment that provides a sense of belonging, where they are comfortable bringing their authentic self to the training experience and empowered to reach their full potential.

PI_NAMEs: RHOADES (STERLING), JULIE A;SEREZANI, C. HENRIQUE ;VELEZ EDWARDS, DIGNA R (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Development;Students

PROJECT_TITLE: Initiative for Maximizing Student Development (IMSD) at Vanderbilt

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Prevention;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Brain metastases occur in almost half of the triple negative and epidermal growth factor receptor positive breast cancer patients and are strongly associated with a high mortality rate among US women patients. The present application will identify and develop a novel predictive marker to enable early detection of brain metastasis, and the conceptual advances of cMET/MUC5AC-axis in the metastatic brain microenvironment could lead to the development of effective management strategies. The current proposal will block the cMET/MUC5AC-axis as a novel targeting approach for targeting brain metastasis of TN and ErbB2-positive BC patients.

PI_NAMEs: NASSER, MOHD WASIM (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;American;Archives;Astrocytes;Attenuated;Bioinformatics;Biological Models;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;brain tissue;Breast Cancer Cell;Breast Cancer Early Detection;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;cancer cell;Cancer Etiology;cancer subtypes;Case Study;CD44 gene;Cell Adhesion;Cell Line;Cells;Central Nervous System;Cisplatin;cohort;Death Rate;design;Development;Diagnosis;Diagnostic;Distant;Early Diagnosis;Early identification;Epidermal Growth Factor Receptor;Epigenetic Process;ERBB2 gene;Evaluation;Failure;FDA approved;Gel;Genetic;Genetic Engineering;Growth;HGF gene;high risk;Hyaluronic Acid;improved;in silico;In Vitro;in vivo Model;inhibitor;knock-down;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Microglia;migration;Molecular;Motility;mouse model;MUC5AC gene;Mucins;novel;novel therapeutic intervention;Organ;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;phase 1 testing;Polymers;pre-clinical;Pre-Clinical Model;Predictive Factor;predictive marker;Prevention strategy;Preventive;Primary Neoplasm;Process;Proteins;receptor;Regulation;Relapse;Role;Serum;Signal Transduction;Survival Rate;targeted treatment;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;treatment response;triple-negative invasive breast carcinoma;Woman;women patients

PROJECT_TITLE: Targeting MUC5AC mucin in breast cancer brain metastasis

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE & RELEVANCE There are up to 100 million chronic pain sufferers in the US, a majority of whom seek treatment via physical rehabilitation. Rehabilitation for orthopedic and neurologic conditions often involves the use of motor learning strategies, in which new movement patterns are developed using repeated task practice, but we currently have very little knowledge of how pain impacts motor learning, especially in older adults. The purpose of this project will be to thoroughly examine the effects of pain on motor learning processes in young and older adults with and without chronic pain.

PI_NAMEs: MORTON, SUSANNE M (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acute Pain;Adult;Affect;Age;Area;Attention;Awareness;Back;Brain;Chronic disabling pain;Chronic low back pain;chronic pain;chronic painful condition;Clinical;Cognition;Cognitive;cognitive ability;Data;Dementia;disability;Educational process of instructing;Elderly;experience;functional improvement;Goals;Impaired cognition;Impairment;improved;insight;Intervention;Knowledge;Learning;learning strategy;Lifting;Link;Literature;Longitudinal cohort;Measures;Mechanics;Mediating;Memory;Motor;motor learning;Movement;neural circuit;Neurologic;Neuronal Plasticity;non-opioid analgesic;novel;older adult;Orthopedics;Pain;pain reduction;Pathway Analysis;patient population;Patients;Pattern;Persistent pain;Physical Function;Physical Rehabilitation;Physical therapy;Play;Population;Prefrontal Cortex;Probability;Process;Provider;Recommendation;Rehabilitation Outcome;Rehabilitation therapy;Research;response;Role;Short-Term Memory;somatosensory;Testing;Therapeutic Intervention;Visual;Work;young adult

PROJECT_TITLE: Pain and Motor Learning in Older Adults

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Human vision is best at the fovea, yet we know much less about the specific code that the retina uses to convey the retinal image to the brain than we do about peripheral retina. This project will use a new technological approach to survey the different kinds of retinal cells that provide us with vision at the fovea, knowledge that could accelerate the development of new approaches to restoring vision in the blind.

PI_NAMEs: WILLIAMS, DAVID R (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TITLE: High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate Eye


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Interventional Cone Beam CT (CBCT) provides critical 3D information to guide minimally-invasive procedures in the abdomen, but CBCT image quality is often compromised by organ deformation due to breathing, cardiac, and peristaltic motions. We propose a novel framework to mitigate the effects of this complex deformable motion using only the CBCT image data, without a need for gating, external trackers, or fiducial markers. This algorithm will remove a major impediment to 3D guidance in procedures such as transcatheter embolization procedures in the abdomen.

PI_NAMEs: ZBIJEWSKI, WOJCIECH BARTOSZ (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Affect;Algorithms;Angiography;Animal Experiments;Animals;Architecture;arm;Arterial Embolization;Arteries;Blood Vessels;Breathing;Cadaver;Cardiac;Characteristics;Chemoembolization;Clinical;clinical application;Clinical Research;Compensation;Complex;cone-beam computed tomography;convolutional neural network;Data;deep learning;design;Emergency Situation;Evaluation;Exhibits;experimental study;feeding;Fluoroscopy;Frequencies;Head;heart imaging;heart motion;Hemorrhage;Image;image guided;image guided intervention;image guided radiation therapy;image reconstruction;imaging modality;improved;interest;internal control;Intervention;Interventional radiology;Joints;Learning;Lesion;Limb structure;Liver;Machine Learning;Maps;Methods;minimally invasive;Modeling;Morphologic artifacts;Morphology;Motion;novel;Organ;Outcome;Patients;Pelvis;Performance;Periodicals;Periodicity;Peristalsis;Physiological;Play;porcine model;preconditioning;Primary carcinoma of the liver cells;Procedures;Property;Prostate Ablation;Radiation Dose Unit;radiologist;Recurrent tumor;Reporting;Residual state;respiratory;Role;Running;satisfaction;Scanning;Schedule;Signal Transduction;simulation;soft tissue;Spatial Distribution;standard care;Structure;Techniques;Testing;Therapeutic Embolization;Three-Dimensional Image;Time;Training;Validation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Deformable motion compensation for 3D image-guided interventional radiology

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

PHR: COX-2 is a critically important target in cancer that we found to influence mechanical force exerted by cancer cells, the extracellular matrix and cancer associated fibroblasts, and tumor and spleen metabolism. Here we intend to focus on new directions that investigate the role of COX-2 in mechanobiology, and in metabolism and immune suppression to develop new translatable strategies to improve triple negative breast cancer treatment outcome. We will also deliver COX-2 siRNA using novel dextran nanoparticles that will also be modified to scavenge cytokines in the tumor microenvironment.

PI_NAMEs: BHUJWALLA, ZAVER M. (contact)

PROJECT_TERMS: 4T1;Arachidonic Acids;Biological Assay;Biological Markers;biomaterial compatibility;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cell motility;Cells;Collagen;Collagen Fiber;cyclooxygenase 2;cytokine;Development;Dextrans;Dinoprostone;Down-Regulation;Eicosanoids;Environment;Extracellular Matrix;Fiber;Fibroblasts;Flow Cytometry;Funding;Generations;Genetic Engineering;Glucose;Glutamates;Glutamine;Grant;Human;Image;image guided;Immune;Immune system;Immunocompetent;Immunohistochemistry;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;Inbred BALB C Mice;Inflammation;Inflammation Mediators;Inflammatory Response;Intercellular Fluid;Invaded;Magnetic Resonance Spectroscopy;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;MDA MB 231;mechanical force;mechanotransduction;Mediating;Metabolic;Metabolism;Microscopy;Modification;Molecular;mRNA Expression;Mus;nanomedicine;nanoparticle;nanoparticle delivery;Neoplasm Metastasis;novel;optical imaging;overexpression;Pattern;photoimmunotherapy;Physiological;Play;Production;Prognosis;Prostaglandin-Endoperoxide Synthase;protein expression;Reaction;Regulation;Role;SCID Mice;second harmonic;siRNA delivery;Small Interfering RNA;Source;Spleen;Splenocyte;Structure;Time;Traction;translatable strategy;Treatment outcome;triple-negative invasive breast carcinoma;tumor;Tumor Escape;tumor microenvironment;Tumor Promotion;Tumor-Derived;Tumor-infiltrating immune cells;Western Blotting;Xenograft procedure

PROJECT_TITLE: Hostile Environments Promote Invasion and Metastasis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Neurosciences;Patient Safety;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: NEUROLOGY

PHR: NARRATIVE This MRI ancillary study will add advanced imaging at 1- and 12-months follow-up to a randomized controlled trial (RCT) of aggressive antipyretic therapy in pediatric CNS malaria in Zambia and Malawi that is aimed at When added to this RCT, imaging insights will facilitate evaluation of neuroprotective mechanisms beyond fever reduction as well as potential intervention-related injuries that might otherwise be undetected. In providing early evidence of brain injury, this MRI ancillary study may also further inform global malaria care guidelines and the design of future RCTs. temperature reduction.

PI_NAMEs: BIRBECK, GRETCHEN L. (contact);POTCHEN, MICHAEL JAMES

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acetaminophen;Acute;acute infection;Adverse effects;Adverse event;Affect;African;Age;Ancillary Study;Anti-Inflammatory Agents;Antiinflammatory Effect;antipyretic;Autopsy;Behavior assessment;Blinded;Blood;Blood Platelets;blood product;Brain;brain abnormalities;Brain Injuries;Caring;Child;Child Care;Childhood;Clinical Treatment;Clinical Trials;Clinical Trials Data Monitoring Committees;cognitive testing;Data;design;Early identification;Enrollment;Evaluation;Evolution;Fever;follow-up;Future;Goals;Guidelines;Hemorrhage;Hemosiderin;Ibuprofen;Image;Infrastructure;Injury;insight;Intervention;Intervention Trial;Intraventricular;Lesion;Link;Location;Longterm Follow-up;Magnetic Resonance Imaging;Malaria;malaria infection;Malawi;Mediating;Methods;Negative Finding;neuroimaging;Neurologic;Neurological outcome;neuroprotection;Outcome;Pathway interactions;Phase;Population;Prevalence;primary outcome;programs;Property;Proxy;radiologist;Randomized, Controlled Trials;Recovery;Research;Research Design;Residual state;Risk;Risk Factors;routine care;scale up;Severities;Stains;Structural defect;Temperature;tool;treatment as usual;treatment response;treatment stratification;treatment-related injury;Zambia

PROJECT_TITLE: An MRI Ancillary Study of Malaria Fever Control RCT

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer

PHR: Project Narrative Even expert radiologists can find it challenging to detect the presence of a subtle, low-contrast pulmonary nodule in a chest X-ray, which could potentially indicate cancer. This project will develop a validated computational approach to generate a diverse and visually realistic set of simulated nodules in real chest X-ray images, in order to i) characterize radiologist performance on an image-by-image basis, ii) develop an image- computable model of expert performance, and iii) create a novel learning-based paradigm to characterize the perceptual and cognitive mechanisms of nodule detection. This project will provide foundational knowledge of the visual and cognitive processes that underlie expertise in nodule detection, and will promote the development of a learning-based protocol to enhance the diagnostic training of radiology residents and other medical professionals.

PI_NAMEs: TONG, FRANK  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatomy;Appearance;Articulation;Attention;base;Behavioral;Biomedical Engineering;Cancer Etiology;Cessation of life;Chest;Chest imaging;Clinic;clinical training;clinically relevant;Cognitive;cognitive process;Collaborations;Complex;computational neuroscience;Computer Models;Computing Methodologies;Data;Detection;Development;Diagnostic;diagnostic tool;experience;Goals;Health;Heart;Human;Image;improved;Incidence;Knowledge;Learning;Lung;lung basal segment;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medical Imaging;men;Methods;model development;Modeling;Nature;Nodule;novel;Outcome Measure;Participant;Pathology;Patients;Perception;Performance;Persons;Property;Protocols documentation;Pulmonary Coin Lesion;Pulmonary vessels;radiologist;Radiology Specialty;Reader;Reporting;Research;Research Personnel;rib bone structure;Signal Transduction;success;Survival Rate;Thoracic Radiography;Training;United States;Variant;Vision;Visual;visual learning;visual processing;Woman;X-Ray Medical Imaging

PROJECT_TITLE: Learning the visual and cognitive bases of lung nodule detection


NIH_SPENDING_CATS: Biotechnology;Cancer;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Prostate cancer stem cells (PCSCs) constitute prostate initiation, progression, metastasis as well  as drug resistance, leading to castration-resistant prostate cancer (CRPC), which  represents a highly aggressive cancer with poor outcome due to the lack of an effectively  targeting strategy. Our study aims to identify novel druggable targets critical for maintaining  PCSCs and CRPC progression in order to develop an effectively therapeutic strategy to target  PCSC-mediated CRPC progression and drug resistance. Our study will not only reveal a paradigm-shift  concept and novel mechanistic insight for PCSC regulation, but also offer a highly effective  strategy for targeting CRPC.

PI_NAMEs: LIN, HUI-KUAN  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Ablation;advanced prostate cancer;AKT Signaling Pathway;aldehyde dehydrogenases;androgen deprivation therapy;androgen independent prostate cancer;Androgens;assay development;Automobile Driving;Back;Biochemical;Biological Assay;cancer drug resistance;Cancer Etiology;cancer initiation;Cancer Patient;cancer stem cell;Cell Maintenance;Cell Proliferation;Cell Survival;Cells;Cessation of life;clinically relevant;clinically significant;Defect;Development;Drug resistance;druggable target;experimental study;Genetic;genetic approach;Goals;Human;Impairment;in vivo;innovation;Inositol;insight;knock-down;Light;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Metabolic;Metabolic Pathway;metabolomics;Mitochondria;mouse model;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;Outcome;overexpression;Pathologic;patient derived xenograft model;Patients;pharmacologic;Phosphotransferases;Physiological;Play;Population;Prostate;Prostate Ablation;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Proteins;Regulation;Reporting;Resistance;resistance mechanism;RNA Splicing;Role;Signal Pathway;Signal Transduction;Solid;Specimen;stem cell biomarkers;Stem Cell Factor;stem cell population;stemness;survival outcome;Testing;therapeutic target;therapeutically effective;therapy resistant;transcriptomics;tumor;tumor metabolism;United States;Validation;Variant;Xenograft Model

PROJECT_TITLE: Unravel a novel metabolic pathway orchestrating prostate cancer progression and therapeutic resistance

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Complementary and Integrative Health;Mental Health;Prevention

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: NARRATIVE The proposal will: (1) establish a broad network that brings together a corps of interdisciplinary researchers to establish innovative and rigorous scientific bases to understand emotional well-being (EWB); (2) contribute important foundational knowledge of EWB by advancing a new generation of measurement and mechanistic research together; and (3) ultimately provide important information about understanding and promoting EWB across the life course including the use of mind-body interventions (MBIs), risk and protective factors as well as windows of opportunity to promote EWB.

PI_NAMEs: CHAFOULEAS, SANDRA M;HOEFT, FUMIKO ;PARK, CRYSTAL L. (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Address;Adult;Age;Anxiety;Area;base;biobehavior;Biological;career;Caregivers;Child;Child Welfare;Collaborations;Collection;Consensus;Development;Dimensions;Discipline;dissemination strategy;Effectiveness;Ensure;Exclusion;Functional disorder;Future;Generations;Goals;Happiness;Health;improved;innovation;instrument;Interdisciplinary Study;intergenerational;Intervention;Knowledge;Learning;lens;Life;Life Cycle Stages;life span;Link;Meaning and purpose;Measurement;Measures;Mediator;meetings;Mental Depression;Mental Health;Methodology;Mind-Body Intervention;mind/body;Modality;Multimedia;neuroimaging;Outcome;Patient Self-Report;Personal Satisfaction;physical conditioning;Pilot Projects;Population;positive emotional state;protective factors;psychologic;Psychometrics;Public Health;Research;Research Personnel;Resource Sharing;Resources;Risk Factors;Role;satisfaction;Science;Series;social;sound;Stress;Taxonomy;theories;tool;transmission process;Well in self;Work

PROJECT_TITLE: Network to Advance the Study of Mechanisms Underlying Mind-Body  Interventions and Measurement of Emotional Wellbeing


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Recent electron paramagnetic resonance (EPR) images (EPRI) of absolute pO2 in murine tumors have shown for the first time significantly improved tumor cure when hypoxic regions were specifically targeted for dose boosts when compared to dose boosts to equal volumes of well oxygenated tumor. For translation to routine clinical use of this radiotherapy strategy, we will use preclinical EPR pO2 images as a ground truth, to develop novel methods to derive a signature from a suite of magnetic resonance (MR) images of several tissue physiologic factors, available for human use, to sharpen the definition of tumor hypoxia delineated by positron emission tomography (PET) images using a hypoxia radiotracer, 18F-fuoronitroimidazole (FMISO). The resulting modified PET-FMISO images can more accurately represent and emulate EPRI pO2 images, which can be used in turn in image-guided radiation therapy of hypoxia tumors with improved delivery and effectiveness.

PI_NAMEs: CHEN, CHIN-TU  (contact);HALPERN, HOWARD J

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-Dimensional;3D Print;Affect;Animals;Behavior;Biochemical;Biological;Blood Vessels;Breast Carcinoma;Cervix Uteri;Chemicals;Clinical;clinical practice;clinically relevant;contrast enhanced;Data;Data Correlations;Defect;Dependence;Dose;Effectiveness;Electrodes;Electron Spin Resonance Spectroscopy;experimental study;fibrosarcoma;France;Head and neck structure;Human;human imaging;Hypoxia;Image;image guided;image guided radiation therapy;imaging approach;imaging modality;imaging system;improved;Inbred C3H Mice;interest;Kinetics;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Measures;Methodology;Methods;mouse model;Multimodal Imaging;multimodality;Mus;novel;Organ;Outcome;Oxygen;Paint;Paper;parametric imaging;Partial Pressure;Patients;Perfusion;Peripheral;Phase II Clinical Trials;physiologic model;Physiological;Positron-Emission Tomography;pre-clinical;Precision therapeutics;preclinical study;predictive modeling;Predictive Value;Printing;Protocols documentation;Publications;quantitative imaging;Radiation;radiation delivery;Radiation Dose Unit;radiation effect;Radiation therapy;radiotracer;Randomized;Reporting;Research Project Grants;Resistance;Sarcoma;Source;Standardization;Statistical Methods;Structure;therapy outcome;Time;Tissues;tool;Translations;Treatment outcome;tumor;tumor hypoxia;tumor microenvironment;Tumor Oxygenation;Tumor Volume;uptake;Validation;Work

PROJECT_TITLE: Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging  - Resubmission 01

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]