PHR: The proposed project is relevant to public health because it aims to investigate how genetic risk variants found in the general population affect an individual’s chance of developing Alzheimer’s disease and how to best develop treatment for it. The proposed research is in alignment with the mission of the Department of Veterans Affairs to improve the health and well-being of older Veterans.

PI_NAMEs: YUAN, SHAUNA H (contact)

PROJECT_TERMS: Acceleration;activating transcription factor 4;Affect;Age;Alzheimer's Disease;Animal Model;Autopsy;behavior test;biological adaptation to stress;Brain;Brain Diseases;Clinical Management;Clinical Treatment;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Code;design;Dose;effective therapy;Endoplasmic Reticulum;endoplasmic reticulum stress;Eukaryotic Initiation Factors;Exhibits;experience;gain of function;General Population;Genetic;Genetic Risk;Genetic Variation;genome wide association study;Genotype;Goals;Grant;Haplotypes;Health;Homeostasis;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;inhibitor;inhibitor therapy;insight;Intervention;Investigation;Knowledge;Methodological Studies;misfolded protein;Mission;morris water maze;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Performance;Personal Satisfaction;personalized medicine;pharmacologic;Phosphotransferases;Population;precision medicine;prevent;Process;Prokaryotic Initiation Factor-2;Protein Biosynthesis;Proteins;Proteome;Public Health;Regulation;remediation;Research;Research Personnel;response;Risk;risk variant;sensor;Single Nucleotide Polymorphism;Stress;Synapses;targeted treatment;tau Proteins;Tauopathies;Testing;therapy development;transcription factor CHOP;Transgenes;Trazodone;Treatment Efficacy;treatment response;treatment strategy;United States Department of Veterans Affairs;United States National Institutes of Health;Variant;Veterans;Western Blotting

PROJECT_TITLE: Investigation of the effects of genetic risk variants in the Unfolded Protein Response on tauopathy pathogenesis


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Depression;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Palliative Care;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Cardiorespiratory diseases are the most common causes of mortality and morbidity worldwide, including high rates of psychological distress symptoms (e.g., depression, anxiety, PTSD). Although symptomatic patients experience worse outcomes from their cardiorespiratory conditions, there are few interventions designed to address this problem at the population scale needed. This application is designed to test Blueprint, a self- directed mobile app-based intervention for psychological distress versus an Education Program control in a multicenter, efficacy-focused clinical trial with specific targets for enrollment by race, ethnicity, gender, and Spanish spoken as a first language.

PI_NAMEs: HOUGH, CATHERINE LEE;MORRIS, CYNTHIA D (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Adherence;Age;Anxiety;Behavioral;Biometry;Black race;Characteristics;Clinical;Clinical Trials;clinically relevant;Cognitive Therapy;Colorado;community engagement;comparison control;Congestive Heart Failure;Coping Skills;COVID-19;COVID-19 pneumonia;Critical Illness;Data;data infrastructure;data integrity;data management;data quality;Data Reporting;depressive symptoms;design;disadvantaged background;Disease;Distress;Education;Educational Intervention;efficacy testing;Electronic Health Record;Elements;Eligibility Determination;emotion regulation;Enrollment;Ensure;ethnic minority population;Ethnic Origin;experience;Failure;follow-up;future implementation;Gender;Health;health care delivery;health equity;Heterogeneity;Hispanic;Home;Hospitalization;Hospitals;Hybrids;implementation framework;implementation outcomes;Implementation readiness;improved;Infrastructure;innovation;interest;Intervention;intervention delivery;Interview;Language;Lead;Mental Depression;Mental Health;Mental Health Services;Methods;mHealth;mobile application;Modeling;Morbidity - disease rate;mortality;Online Systems;Oregon;Outcome;Participant;Patients;Persons;physical symptom;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Post-Traumatic Stress Disorders;primary outcome;Problem Solving;programs;Protocols documentation;psychological distress;psychological symptom;quality assurance;Quality of life;Race;racial minority population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Relaxation;Reporting;Research;Research Priority;response;Safety;Sampling;Security;Self Direction;Self Efficacy;Sepsis;Severity of illness;Site;skills;social;social factors;sociodemographics;Spanish;Structure;Subgroup;Survivors;symptom treatment;Symptoms;Telephone;Testing;therapy design;Time;tool;Training Programs;treatment effect;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: 2/2 Self-directed mobile adaptive coping skills intervention to improve psychological distress symptoms among cardiorespiratory failure survivors: the Blueprint RCT

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (OA)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: CA

PHR: Project Narrative Age-related macular degeneration (AMD) is a debilitating blinding disease of older age that is prevalent in the Veteran population. Although perturbed vitamin A and ocular retinoid metabolism have been implicated in AMD pathogenesis, limitations in our understanding of these pathways has hampered efforts to therapeutically intervene in this disease. The goal of this proposal is to genetically or pharmacologically modulate pathways linked to vitamin A metabolism and retinal disease pathogenesis to gain insights necessary for development of novel therapies to treat retinopathies including AMD.

PI_NAMEs: KISER, PHILIP DAVID (contact)

PROJECT_TERMS: absorption;Acetates;Adult;age related;Age related macular degeneration;Animal Model;Binding Proteins;Biochemical;Blindness;Cells;chromophore;Clinical Research;conditional knockout;Data;Development;disability;Disease;Disease Progression;effective therapy;Elderly;Electrophysiology (science);Enzymes;Esters;Eye;Funding;gene-targeted therapy;geographic atrophy;Goals;Grant;Health;Health Care Costs;Healthcare Systems;High Prevalence;Homeostasis;Human;human old age (65+);Hydrolysis;Image;Imaging Techniques;Impairment;improved;Individual;inducible Cre;insight;Investigation;Knock-out;knockout gene;Knockout Mice;Knowledge;lecithin-retinol acyltransferase;Legal Blindness;legally blind;Light;Link;Liver;Maintenance;mature animal;Metabolism;military veteran;Modeling;Modernization;Molecular;mouse model;Muller's cell;Mus;novel;novel strategies;novel therapeutics;Opsin;Pathogenesis;Pathway interactions;Patients;Peripheral;pharmacologic;phosphoric diester hydrolase;Photoreceptors;Physiology;Play;pre-clinical;Process;Proteins;Regenerative pathway;response;Retina;Retinal Diseases;retinal imaging;Retinaldehyde;Retinoids;Retinol Binding Proteins;Role;Site;Structure;Structure of retinal pigment epithelium;Supplementation;Supporting Cell;Symptoms;System;Therapeutic;Time;Tissues;tool;trafficking;Veterans;Vision;Vision Disorders;Visual;visual cycle;Visual impairment;Visual Pathways;Visual Perception;Vitamin A

PROJECT_TITLE: Retinoid cycles and retinal disease treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURF-H (01)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Mesothelioma is devastating to Veterans. Inadequate therapies exist for the treatment of mesothelioma, as the median survival for treated metastatic mesothelioma is approximately 1-2 years. Many Veterans were exposed to asbestos via shipbuilding. Ongoing studies suggest that the incidence of mesothelioma is not declining. This may be in part due to issues with exposure to asbestos fibers via mining. Carbon nanotubes have been shown to induce mesothelioma in mice. Many people who develop mesothelioma have significant co-morbidities that preclude aggressive treatment. The last FDA approval for a new drug for mesothelioma was in 2020, but this immunotherapy-based regimen has modest benefits. Validation of targeting pyrimidine biosynthesis via inhibition of dihydroorotate dehydrogenase (DHODH) as a promising and novel approach to treating mesothelioma will de-risk further development of targeting DHODH as a potential therapeutic strategy against mesothelioma in Veterans.

PI_NAMEs: KLEIN, MARK A. (contact)

PROJECT_TERMS: Address;aggressive therapy;Anabolism;Asbestos;Basic Science;Biological Assay;Cancer Biology;Carbon Nanotubes;CDC2 gene;Cell Cycle Arrest;cell growth;Cell Line;Cell Proliferation;Cells;checkpoint inhibition;Clinical Research;Clinical Trials;Combined Modality Therapy;comorbidity;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;design;Development;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;Disease;Disparity;Drug Combinations;effectiveness evaluation;Enzymes;experience;Exposure to;FDA approved;Fiber;Future;Generations;Genetic;Genomics;Goals;Growth;Immunotherapy;In Vitro;in vivo;Incidence;indexing;inhibitor;innovation;Knowledge;Laboratories;Leflunomide;Link;Lung Adenocarcinoma;Malignant mesothelioma;Malignant Neoplasms;Measures;Mesothelioma;military veteran;Mining;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;nanomolar;novel;novel strategies;novel therapeutics;pancreatic cancer cells;Pathway interactions;Patients;pembrolizumab;Persons;Pharmaceutical Preparations;Population;pre-clinical;preclinical study;Prognosis;Proliferating;Publishing;Pyrimidine;Regimen;Research;Risk;small cell lung carcinoma;synergism;Therapeutic;therapeutic target;treatment strategy;tumor growth;tumor progression;Validation;Veterans;Work

PROJECT_TITLE: Validation of Dihydroorotate Dehydrogenase as a Therapeutic Target in Mesothelioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCB-A (01)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PET radiotracers targeting amyloid beta and hyperphosphorylated tau, the two major hallmark neuropathologies in Alzheimer’s disease (AD), have been successfully developed and are now widely used in clinical research. However, strong evidence suggest that additional pathophysiological processes, such as myelin pathology and vascular dysfunction, may coexist and contribute to the etiology of the disease. We propose to characterize the PET radiotracer [18F]3F4AP’s properties and performance in human subjects with AD, mild cognitive impairment (MCI) and cognitively normal (CN) individuals for detecting and quantifying demyelination and cerebral perfusion.

PI_NAMEs: GUEHL, NICOLAS JEAN (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Address;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animals;Area;Binding;Biological Markers;Blood flow;Blood specimen;Brain;Cannulations;Cerebrovascular Circulation;Cerebrum;Clinical;Clinical Research;clinical translation;Cognitive;Craniotomy;Demyelinations;Disease;Drug Kinetics;early detection biomarkers;Etiology;Evaluation;Functional disorder;Goals;gray matter;human subject;hyperphosphorylated tau;Image;imaging properties;in vivo;indexing;Individual;kinetic model;Kinetics;Lesion;Light;Magnetic Resonance Imaging;Measurement;Measures;Metabolism;Methods;mild cognitive impairment;Modality;Multiple Sclerosis;Myelin;myelination;Neurofibrillary Tangles;neuron loss;neuropathology;nonhuman primate;Outcome;Outcome Measure;Pathologic;Pathologic Processes;Pathology;Performance;Perfusion;Permeability;Phase;Play;Positron-Emission Tomography;Potassium;preclinical study;Procedures;Process;Property;Protocols documentation;radiotracer;Research;Resolution;response;Role;Scanning;Senile Plaques;Specificity;success;Synapses;tau Proteins;Tauopathies;Techniques;Testing;Tracer;Vascular Diseases;voltage;Water;white matter

PROJECT_TITLE: PET imaging for in-vivo quantification of demyelination and cerebral perfusion in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (81)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE People experiencing homelessness have been substantially and disproportionately impacted by the opioid overdose crisis. Though retention in opioid use disorder treatment reduces mortality in this population, retention is suboptimal. In this proposal, the investigators will use a community-engaged approach to develop and pilot test a tailored peer recovery support intervention to promote opioid use disorder treatment retention among people experiencing homelessness.

PI_NAMEs: FINE, DANIELLE REBECCA (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;acceptability and feasibility;addiction;Address;Affect;Area;Attention;Attitude;Award;behavior change wheel;Boston;career;Caring;Characteristics;Clinic;Clinical;clinical epidemiology;clinical infrastructure;Clinical Trials;Collaborations;Communities;community advisory board;community collaboration;community engaged approach;community engaged research;Consensus;Coupled;Data;Death Rate;design;Disparity population;Drops;Education;effectiveness evaluation;Enrollment;Epidemiology;Evaluation;experience;Face;feasibility testing;Focus Groups;Foundations;Funding;Future;General Hospitals;General Population;Goals;Health;Health Services Research;Healthcare;Heterogeneity;high risk population;Homelessness;improved;improved outcome;Individual;individualized medicine;informant;Infrastructure;Intervention;Intervention Trial;Interview;Literature;Lived experience;marginalized population;Massachusetts;medical schools;medication for opioid use disorder;Medicine;Mentored Clinical Scientist Development Program;Mentors;Methodology;Methods;mortality;National Institute of Drug Abuse;Opioid;opioid overdose;opioid use disorder;Overdose;overdose death;Participant;Patients;peer coaching;peer recovery;Persons;Pharmaceutical Preparations;Physician Executives;Physicians;pilot test;Population;Positioning Attribute;primary outcome;Principal Investigator;Process;programs;Public Health;Qualifying;Questionnaires;Randomized;Randomized, Controlled Trials;Recovery;recovery services;Recovery Support;recruit;Reduce health disparities;Research;Research Activity;Research Design;Research Methodology;Research Personnel;research study;Risk;Sampling;Science;screening;Services;social capital;social health determinants;Social support;Socialization;Specialist;Standardization;Strategic Planning;substance use;Substance Use Disorder;Testing;therapy development;Training;treatment arm;treatment as usual;Treatment outcome;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Peer recovery support for people experiencing homelessness with opioid use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Suicide is a major health crisis within our Veteran population. Inflammation is associated with suicide risk. Understanding the biological mechanisms linking inflammation and suicidal thoughts and behavior is critical to developing diagnostic tools and preventative treatments for Veterans at risk of suicide. This study will assess the contribution of inflammatory processes in the brains of suicide decedents at the molecular level, with the goal to identify genetic factors that contribute to inflammation and risk of suicide.

PI_NAMEs: HAGHIGHI, FATEMEH G (contact)

PROJECT_TERMS: Accidents;Anti-Inflammatory Agents;Autopsy;Back;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;Brain;Cause of Death;Cell Nucleus;Cells;Cessation of life;Clinical;cytokine;Data;data resource;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;DNA Methylation;DNA Sequence Alteration;epigenetic marker;Epigenetic Process;Feeling suicidal;Fluorescence;Gene Cluster;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;genetic variant;genome-wide;Genomic approach;Goals;Health;high risk;Human;Immune response;Immunologics;improved;indexing;Individual;Inflammation;Inflammatory;Investigation;Laboratories;Link;Logistic Regressions;Major Depressive Disorder;Measures;Mediating;Mediation;Mental disorders;Methods;Methylation;methylation pattern;Microglia;military veteran;Mission;Modeling;Molecular;Nature;Nervous System Disorder;Neuroglia;Neuroimmunomodulation;neuroinflammation;novel strategies;Oligodendroglia;Participant;Pathway Analysis;Pathway interactions;Pattern;personalized medicine;Phagocytes;polygenic risk score;Population;portability;Prefrontal Cortex;Preventive treatment;Process;programs;psychologic;Psychopathology;Recording of previous events;Research;Risk;risk prediction;risk variant;Sampling;Schizophrenia;Sorting;Specimen;Statistical Models;suicidal;suicidal behavior;suicidal patient;suicidal risk;Suicide;suicide attempter;suicide brain;suicide model;suicide rate;Testing;Tissue Sample;Tissues;Transcript;transcriptome;Underrepresented Populations;United States;Validation;Veterans;white matter

PROJECT_TITLE: Bidirectional validation of loci associated with suicide risk using the Million Veteran Data and postmortem human brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-N (01)]


ORG_CITY: Decatur

ORG_STATE: GA

PHR: NARRATIVE Antibiotic resistance is one of the greatest medical challenges of our time; to effectively treat resistant bacterial infections it is critical to have accurate and personalized data on which drugs can kill infecting strains. We have discovered that a widespread yet vastly underappreciated form of antibiotic resistance (heteroresistance) that is undetectable by current tests can cause treatment failures. We have developed a novel antibiotic susceptibility testing technology that is more sensitive, highly accurate, and faster than current tests, and has the potential to significantly improve the care of Veterans and other patients, potentially saving lives.

PI_NAMEs: WEISS, DAVID S (contact)

PROJECT_TERMS: Affect;Agar;Agreement;Antibiotic Resistance;antibiotic resistant infections;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Attention;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Biology;Blood;Caring;cell killing;Cells;Cessation of life;chemotherapy;Clinical;Clinical Microbiology;Clinical Trials;clinically relevant;Collection;combat;Combined Antibiotics;Combined Modality Therapy;Consumption;Data;Detection;detection platform;Development;Diagnostic;Dyes;efficacy testing;Ensure;Equilibrium;Exhibits;extreme prematurity;Failure;Health Care Costs;Hour;improved;Incubated;Infection;innovation;Interferometry;Intermediate resistance;Laboratories;Laboratory Research;Light;Malignant Neoplasms;Manuals;Maps;materials science;Measurement;Measures;Medical;Methods;Minor;Modern Medicine;nanometer resolution;new technology;next generation;novel;novel therapeutics;Operative Surgical Procedures;Optics;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Physics;Population;Population Analysis;predict clinical outcome;Predisposition;Process;processing speed;Property;Protocols documentation;rapid testing;Regimen;Research;Resistance;Resistance profile;Resolution;Retrospective Studies;Risk Reduction;Sampling;Scanning;Selection for Treatments;Shapes;Speed;Stains;Surface;System;Technology;Testing;Time;Transplantation;Treatment Failure;Veterans;Work;World Health;World Health Organization

PROJECT_TITLE: Novel Antibiotic Susceptibility Testing Platform for Detecting Resistant Subpopulations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Babies born with complex heart defects often experience a lifetime of surgeries and hospitalizations accompanied by both short and long-term injury to their vital organs (including their brain, heart, kidneys, and intestines). In this project, we will use new laboratory tests capable of measuring hundreds of proteins and metabolites from a tiny blood sample to explore how our children’s bodies respond to their heart surgery and subsequent vital organ injury. We will also use the millions of data points collected to train a new generation of young scientists to improve outcomes for children with complex heart defects using data science techniques.

PI_NAMEs: DAVIDSON, JESSE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acute;Address;Adopted;Animal Model;Biological Assay;Biological Markers;Blood specimen;Blood Vessels;Brain;candidate marker;Cardiac;Cardiac Surgery procedures;Cardiology;Cardiopulmonary Bypass;Cardiovascular system;career;career development;Caring;Child;Childhood;Chronic;Clinical Data;cohort;Complex;congenital heart abnormality;cost;Data;Data Analyses;Data Science;Data Set;Dedications;Development;Diagnostic;diagnostic strategy;early-career faculty;Environment;experience;Failure;Foundations;Frustration;Functional disorder;Funding;Generations;Growth;Heart;heart defect;Heart Diseases;Hospitalization;improved;improved outcome;Incidence;Infant;Injury;interest;Intervention;intestinal injury;Intestines;Kidney;Laboratories;large datasets;Learning;Life;Longitudinal cohort;Lung;Mass Spectrum Analysis;Measurement;Measures;Mentors;Metabolic;metabolome;metabolomics;Methods;Midcareer Investigator Award in Patient-Oriented Research;Molecular;molecular phenotype;Morbidity - disease rate;mortality;multidimensional data;Multiple Organ Failure;National Heart, Lung, and Blood Institute;Neonatal;neonatal surgery;Nervous System Trauma;next generation;novel;novel strategies;Operative Surgical Procedures;Organ;organ injury;Outcome;palliation;Pathologic;Pathway interactions;patient oriented;patient oriented research;Patients;Perioperative;Phenotype;Physicians;Postoperative Period;Productivity;programs;protein biomarkers;Proteins;Proteome;Proteomics;Recovery;repaired;Research;Research Personnel;response;Risk;Science;Scientist;Single ventricle congenital heart disease;skills;Stream;Systems Biology;Techniques;Technology;Testing;Therapeutic;Therapeutic Studies;Training;training data;United States National Institutes of Health;Work

PROJECT_TITLE: Systems biology of acute and chronic multi-organ failure in children with congenital heart disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Oxidized phospholipids containing phosphocholine (PC-OxPLs) are pathogenic in multiple diseases and their deleterious effects are blocked by the natural antibody E06 IgM. Transgenic expression of E06 causes bone anabolism and prevents age-and high fat diet-associated bone loss by increasing osteoblasts and bone formation; in addition, it prevents atherosclerosis, steatohepatitis and cardiovascular diseases. Therefore, anti- PC antibodies, may be a novel therapy to ameliorate multiple diseases. We will investigate the mechanisms by which E06 causes bone anabolism, and whether injections of a murine monoclonal E06 IgG increase bone mass in young and old mice. Endogenous levels of anti-PC IgM antibodies are inversely correlated with bone density in humans. We will measure the levels of anti-PC IgM in a cohort of patients from the Osteoporotic Fractures in Men (MrOS) study and the Study of Osteoporotic Fractures (SOF) in women and determine whether the levels of these antibodies correlate with longitudinal changes of BMD and fractures.

PI_NAMEs: AMBROGINI, ELENA  (contact)

PROJECT_TERMS: Adverse effects;Affect;Age;Age Months;age-related disease;aged;Aging;Anabolism;Antibodies;antigen binding;Apoptosis;Apoptotic;Atherosclerosis;Binding;bone;Bone Density;Bone Formation Inhibition;bone loss;bone mass;Cardiovascular Diseases;cell injury;Cell membrane;Cells;Clinical Research;cohort;Cross-Sectional Studies;Disease;Elderly;epidemiology study;Epitopes;Exposure to;Fatty acid glycerol esters;Female;Femur;Fracture;Gender;Genes;Head;High Fat Diet;Human;Immunoglobulin G;Immunoglobulin M;In Vitro;in vivo;Injectable;Injections;Intravenous;Lecithin;Ligands;Lipid Peroxidation;Lipoproteins;male;Measures;Mediating;men;microvesicles;military veteran;Minerals;Molecular Conformation;murine monoclonal antibody;Mus;natural antibodies;Neck;neutralizing monoclonal antibodies;novel therapeutics;old mice;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;overexpression;oxidation;oxidized low density lipoprotein;Pathogenicity;Patients;peroxidation;pharmacologic;Phenotype;Phospholipids;Phosphorylcholine;Play;Polyunsaturated Fatty Acids;preclinical study;Predisposition;prevent;Proliferating;protective effect;Race;Reactive Oxygen Species;Reperfusion Injury;Role;single-cell RNA sequencing;Site;spine bone structure;Steatohepatitis;Testing;Therapeutic Intervention;therapeutically effective;Time;transcriptome sequencing;transgene expression;Transgenes;Transgenic Mice;Trochanters;vascular inflammation;Veterans;WNT Signaling Pathway;Woman

PROJECT_TITLE: Antibodies against Oxidized Phospholipids and Osteoporosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDB-P (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Molecular and cellular mechanisms that contribute to the modulation of mechanotransduction and mechanosensitivity under normal, pathological, or adaptive conditions remain to be fully elucidated. The objective of this proposal is to investigate biophysical basis of mechanosensitivity under conditions of prolonged hypothermia, using hibernating thirteen-lined ground squirrels as a naturalistic model. Insights gleaned from these studies will facilitate rational development of pharmacology to alleviate symptoms associated with neuropathic somatosensory dysfunction in humans.

PI_NAMEs: BAGRIANTSEV, SVIATOSLAV  (contact);GRACHEVA, ELENA

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acceleration;Action Potentials;Affect;Afferent Neurons;Animals;animation;associated symptom;Attenuated;Biological;biophysical analysis;Biophysics;Body Temperature;Cells;chemotherapy;clinical practice;cold temperature;Data;Detection;Development;Drops;Electrophysiology (science);Event;experimental study;Exposure to;Fire - disasters;follow-up;Functional disorder;Ganglia;Glean;Goals;Hibernation;Histology;Human;improved;insight;Ion Channel;Ion Channel Gating;Light;Mammals;mechanical allodynia;mechanical force;mechanical stimulus;Mechanics;Mechanoreceptors;mechanotransduction;Mediating;Medical;model organism;Modeling;Molecular;Molecular Target;Mus;natural hypothermia;Nerve;nerve damage;nerve injury;Neurons;Neuropathy;novel;Pain;painful neuropathy;Palliative Care;patch clamp;Pathologic;Pathway interactions;Periodicity;Peripheral;Peripheral Nerves;Pharmacology;Phenotype;Physiological;Physiology;Piezo 2 ion channel;Population;post stroke;Potassium Channel;Preparation;preservation;Process;Property;reduce symptoms;response;Role;Sensory;Signal Transduction;Skin;Sodium Channel;somatosensory;Spermophilus;Spinal Ganglia;Squirrel;Stimulus;System;Temperature;Testing;Touch sensation;Up-Regulation;vibration;virtual;voltage;Voltage-Gated Potassium Channel

PROJECT_TITLE: Molecular mechanisms of somatosensory adaptation to prolonged hypothermia

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Ischemic heart disease due to non-obstructive coronary stenosis and small vessel dysfunction (coronary microvascular disease, CMD) is more common than previously thought. The underdiagnosis of CMD and lack of therapeutic options have resulted from our myopic view of obstructive coronary stenosis as the only reason for chest pain and the requirement for invasive coronary testing. We aim to improve the management of CMD by further targeting our high-resolution cardiac MRI framework and developing methods for non-invasive estimation of patient-specific coronary hemodynamic parameters; both will enable detection, monitoring, and testing of therapeutic interventions for CMD.

PI_NAMEs: NGUYEN, KIM-LIEN T (contact)

PROJECT_TERMS: agent orange;Anatomy;Angiography;Blood;blood fractionation;Blood Vessels;Blood Volume;cardiac magnetic resonance imaging;Cardiovascular system;Catheterization;Cause of Death;Chest Pain;Chronic;Clinical;clinical development;Computer Models;Contrast Media;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary Stenosis;Coupled;COVID-19;Data;Detection;Diagnosis;Diagnostic;Engineering;Event;experimental study;Family suidae;Female;ferumoxytol;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Gadolinium;Goals;Health Resources;healthy volunteer;Heart;Heart Diseases;heart imaging;heart motion;hemodynamics;Heterogeneity;high risk;hypoperfusion;Image;image registration;imaging approach;Impairment;improved;in silico;indexing;insight;Ionizing radiation;Iron;Ischemia;Life Style;Liquid substance;Magnetic Resonance Imaging;Maps;Measures;men;Mental disorders;Methods;Microcirculation;Microvascular Dysfunction;Modeling;Monitor;Morbidity - disease rate;Morphology;Motion;Myocardial;Myocardial Ischemia;Myocardium;non-invasive imaging;off-label use;particle;Patients;Performance;Perfusion;Phase;Physics;pre-clinical;Preclinical Testing;Procedures;Public Health;Quality of life;Radiation;reconstruction;Residual state;Resistance;Resolution;response;Risk Factors;sex;Signal Transduction;Slice;Specificity;Stress;targeted imaging;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Therapeutic Intervention;ultra high resolution;Validation;Veterans;Woman;Work

PROJECT_TITLE: Tailoring Stress Cardiac MRI for Women with Ischemic Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CARA-R (01)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Development of posttraumatic stress disorder (PTSD) symptoms after a myocardial infarction (MI) is common (>35% of patients), with serious implications for increasing risk of rehospitalization and mortality within 1 year. To address the NHLBI Research Priority regarding mechanisms whereby psychosocial stress contributes to ischemic heart disease progression, the proposed K23 study will test psychological and physiological stress reactivity as a mechanism linking PTSD symptoms with elevated ambulatory blood pressure during the post-MI adjustment period. Using ecological momentary assessment and ambulatory blood pressure monitoring, the proposed study will advance our understanding of stress reactivity as a promising modifiable mechanism in MI patients and inform the future development of a larger study of diverse MI patients with PTSD symptoms.

PI_NAMEs: LEE, SHARON Y (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acute;Address;Adult;Affect;Affective;Ambulatory Blood Pressure Monitoring;Arousal;Automobile Driving;awake;Award;behavioral cardiology;Behavioral Medicine;biobehavior;Biological;biological adaptation to stress;Blood Pressure;blood pressure elevation;Cardiac;Cardiology;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Clinical;Clinical assessments;Clinical Psychology;Cognition;Cognitive;Data;Data Collection;Detection;Development;Diagnosis;diagnostic criteria;Disease Progression;Dose;Ecological momentary assessment;Environment;Epidemiology;ethnic difference;Event;experience;Future;Goals;hospital readmission;Hospitals;Hour;Individual;innovation;Intervention;Interview;Knowledge;Laboratories;Laboratory Research;Lead;Life;Link;Longitudinal Studies;Measures;Mediating;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Moods;Morbidity - disease rate;mortality;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Nature;Outcome;Participant;Pathway interactions;Patients;perceived stress;Persons;Physiological;Play;post-traumatic stress;Post-Traumatic Stress Disorders;Preventive;Prognosis;psychologic;Psychological Stress;psychological stressor;Psychological Tests;Psychophysiology;Psychosocial Stress;racial difference;Recovery;Recurrence;Reporting;Research;Research Personnel;Research Priority;Resources;response;Rest;Risk;risk prediction;Role;Scientist;Severities;Sex Differences;Stress;stress disorder;stress reactivity;stressor;Surveys;Symptoms;System;Testing;Thinking;Time;Training;Translating;Universities;Work

PROJECT_TITLE: Posttraumatic Stress and Stress Reactivity After Myocardial Infarction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The progressive neurodegenerative Alzheimer’s disease (AD) became a major global health crisis, with ineffective treatment of amyloid plaque-removal, even the latest drug (Lecanemab) can only extend the self- sustained lifetime with 6 months. We aim to characterize the sequential order of complex neurogliovascular events in a longitudinal multi-modal animal study using novel simultaneous MRI and fluorescent Ca-imaging methods before, after, and at the onset of AD. The simultaneous functional activity and connectivity, cerebrovascular reactivity, metabolism, and vascular health in AD model will reveal views of when these dysfunctions occur and improve the option to intervene before the late state of the disease.

PI_NAMEs: HERMAN, PETER  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;amyloid precursor protein processing;Angiography;Animal Disease Models;Animals;arterial spin labeling;Astrocytes;Behavior;Behavior monitoring;Blood flow;blood oxygen level dependent;Blood Vessels;Blood Volume;Brain;brain abnormalities;brain dysfunction;Brain imaging;Calibration;cerebral autoregulation;cerebral blood volume;Cerebrovascular Circulation;cerebrovascular health;cerebrovascular reactivity;Cerebrovascular system;Cerebrum;Cognition;Complex;Data;Data Set;Dependence;Development;Diagnosis;Disease;Disease Marker;Early identification;Event;Excision;exhaust;experimental study;Fiber;Fluorescence Angiography;fluorescence imaging;Functional disorder;Functional Magnetic Resonance Imaging;global health;glucose metabolism;Goals;Health;Hemoglobin;Image;imaging modality;imaging study;Impaired cognition;Impairment;Implant;improved;ineffective therapies;innovation;insight;Insulin Resistance;Label;Laboratories;Life;Link;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Metabolic;metabolic rate;Metabolism;Methods;mitochondrial dysfunction;Monitor;morris water maze;multimodality;Mus;nanoparticle;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neurotransmission;novel;optical imaging;Optics;Oxidative Stress;Oxygen Consumption;Pathogenesis;Pathologic;Persons;Pharmaceutical Preparations;Proteins;public health relevance;Regulation;response;RF coil;Senile Plaques;Sensory;sensory stimulus;Series;Signal Transduction;Spatial Distribution;spatial memory;Staging;Structure;Surface;Symptoms;System;Task Performances;tau aggregation;Technology;Testing;Therapeutic;Time;tool

PROJECT_TITLE: Impaired cerebral metabolism and blood flow by neuronal and astrocytic dysfunctions in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Stomach Cancer

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Epstein-Barr virus (EBV) infects more than 90% of the human population and is important in a variety of malignancies in humans including Burkitt lymphoma, Hodgkin Lymphoma, nasopharyngeal carcinoma (NPC), and gastric carcinoma. EBV infection of the epithelium is a complicated process that has not been fully elucidated. The proposed studies will contribute to a mechanistic understanding of EBV entry as well as entry process for other herpesviruses into healthy epithelium and may result in the development of novel virus entry inhibitors for EBV as well as other herpesviruses.

PI_NAMEs: LONGNECKER, RICHARD M (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Adult;adult stem cell;Affinity;angiogenesis;B-Lymphocytes;Binding;Burkitt Lymphoma;Calcium;Carcinogens;Cell fusion;cell growth regulation;Cell Physiology;Cells;cofactor;Colon;Complement 3d Receptors;Data;Development;Diffusion;Disease;Eph Family Receptors;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;experience;gammaherpesvirus;Gastric Adenocarcinoma;Gastric mucosa;gastric organoids;Gastric Tissue;Gastritis;Gene Expression;Genes;Genetic Polymorphism;Glycoproteins;Helicobacter Infections;Helicobacter pylori;Herpesviridae;Hodgkin Disease;Human;Human Herpesvirus 4;Infection;Infectious Mononucleosis;Inflammation;Inflammatory;inhibitor;innate immune mechanisms;keratinocyte;knockout gene;Laboratories;laboratory experience;Laboratory Finding;Lipopolysaccharides;Malignant Neoplasms;malignant stomach neoplasm;Membrane;Membrane Proteins;migration;mutant;Nasopharynx Carcinoma;novel;novel strategies;novel virus;Oncogenic;oral cavity epithelium;Outcome;Pathogenesis;Pathogenicity;Pathology;Permeability;Phenotype;Physiological;Play;Population;Predisposition;Prevention strategy;Process;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Research;Risk;Role;Signal Transduction;Signal Transduction Pathway;Simplexvirus;Stomach;Stomach Carcinoma;Tight Junctions;Tissues;treatment strategy;Variant;Viral;Virus;Virus Diseases

PROJECT_TITLE: Epstein-Barr Virus Entry into Epithelial Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Racial and Ethnic Minority Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Intensive searches of the human genome have identified more than 200 genetic risk loci for inflammatory bowel disease. However, understanding how these genetic factors confer risk for inflammatory bowel disease and clinical application are unmet challenges. We will use a cutting-edge single cell trimodal omics approach to study specific subtypes of immune cells isolated from study subjects with European, African American or West African ancestry to gain a better understanding of how human genetic variations predispose individuals to the dysregulation of the immune system that underlies inflammatory bowel disease.

PI_NAMEs: CHEN, WEI ;DUERR, RICHARD H (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;African;African American;African ancestry;Alleles;American;ancestry analysis;Atlases;Biological Assay;Blood Cells;causal variant;Cell Separation;Cell Surface Proteins;cell type;Cells;Chromatin;Chromosome Mapping;Chromosomes;chronic inflammatory disease;CISH gene;Clinical;clinical application;clinical translation;Clinical Trials;Complement;Crohn's disease;Data;data integration;Development;differential expression;Dinoprostone;Disease;Dissection;DNA Sequence;Epigenetic Process;Epitopes;Equilibrium;European;European ancestry;Exhibits;experimental study;Exposure to;Flare;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic association;Genetic Diseases;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomic Segment;Genotype;Human;Human Genetics;Human Genome;IL17 gene;IL1R1 gene;Immune;Immune system;Immunophenotyping;immunoregulation;Individual;Inflammation;Inflammatory Bowel Diseases;Interleukin-1 beta;interleukin-23;Knowledge;Linkage Disequilibrium;Maps;Mediating;memory CD4 T lymphocyte;Modality;Multiomic Data;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Steroidal Anti-Inflammatory Agents;Opportunistic Infections;Outcome;overexpression;Pathogenesis;Pathogenicity;Patients;peripheral blood;Phenotype;Pilot Projects;Play;Population;Probability;Prostaglandin E Receptor;Prostaglandin Inhibition;Quantitative Trait Loci;receptor;Regulatory T-Lymphocyte;Research;Research Personnel;response;Risk;risk variant;Role;Sampling;Signal Transduction;single cell analysis;Stimulus;Study Subject;T-Cell Activation;T-Lymphocyte;Testing;Tissues;trait;Transposase;Ulcerative Colitis;Untranslated RNA;Variant;WFDC2 gene;young adult

PROJECT_TITLE: Trans-ancestry, single-cell multiomics dissection of IBD-associated loci in CD4 memory T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (O1)]


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: Narrative We propose an extensive set of genome-wide association studies of PTSD, which are important for veterans because they can identify specific genetic variants associated with an increased risk for developing PTSD after exposure to trauma. By identifying these genetic risk factors, we create the potential to develop personalized prevention strategies and treatment plans for veterans. Furthermore, these studies can also provide important insights into the biological mechanisms underlying PTSD, which can inform the development of new and more effective treatments for this debilitating disorder.

PI_NAMEs: GELERNTER, JOEL  (contact)

PROJECT_TERMS: African;Alcohol consumption;alcohol use disorder;Alcohols;Alzheimer's Disease;American;Anxiety;Area;Asian ancestry;biobank;Biological;Biology;Cardiovascular Diseases;Characteristics;Clinical;Cocaine use disorder;Collaborations;comorbidity;cooperative study;Copy Number Polymorphism;Data;Data Set;data sharing;Development;Disease;drug repurposing;East Asian;effective therapy;Electronic Medical Records and Genomics Network;Epigenetic Process;Equation;Etiology;Female;follow-up;Functional disorder;General Population;Genetic;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genomics;Human;Impaired cognition;improved;Individual;individualized prevention;insight;interest;Investigation;Journals;Latino;Link;Linkage Disequilibrium;Longitudinal Studies;Maps;marijuana use disorder;Medical;Mendelian randomization;Mental Depression;Meta-Analysis;Methodology;Methods;Methylation;military veteran;Modeling;Molecular;Nature;Neurosciences;Nicotine;Nutritional;Opioid;opioid use disorder;Participant;Pharmaceutical Preparations;Pharmacogenomics;phenome;Phenotype;pleiotropism;Polygenic Traits;Population;Population Genetics;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;Precision therapeutics;Prediction of Response to Therapy;Prevention strategy;Process;Productivity;programs;prospective;psychiatric genomics;Psychiatry;Psychopathology;Publishing;Qualifying;rare variant;Research;Research Personnel;resilience;response;Risk;risk prediction;Sample Size;Sampling;sex;Signs and Symptoms;Soldier;South Asian;Stimulant;Subjects Selections;substance use;Substance Use Disorder;System;Testing;trait;Translations;trauma exposure;treatment planning;United States Department of Veterans Affairs;Veterans;whole genome;Work

PROJECT_TITLE: Genomics of PTSD and Related Traits


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Klebsiella pneumoniae bacteremia can initiate sepsis, a leading cause of global morbidity that causes immense socioeconomic burdens as the most expensive hospital treated condition. This research will define host- pathogen interactions during K. pneumoniae bacteremia, with the goal of identifying pathways that can be targeted or enhanced by future therapies to aid in the clearance of bacteremia. By defining immunomodulatory processes of K. pneumoniae bacteremia that could result in novel therapies, this research directly advances the NIH mission of defining the nature and behavior of living systems to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: HOLMES, CAITLYN LEIGH (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: alveolar bone;Alveolar Macrophages;Bacteremia;Bacterial Genes;bacterial genetics;Bacteriology;Behavior;Biology;Blood;Blood Circulation;blood filter;Bone Marrow;Cell Death;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR library;Data;Dedications;Defect;Development;disability;Disease;Economic Burden;enhancing factor;fitness;Functional disorder;Future;Genes;Genomics;Goals;Growth;Health;healthcare-associated infections;Hospitals;Host Defense;Immune;Immune response;Immunology;immunoregulation;In Vitro;in vivo;Infection;innovation;Kinetics;Klebsiella pneumoniae;Knowledge;Life;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;Liver;Lung;Lung immune response;Macrophage;Mediating;Mentors;Michigan;Mission;Morbidity - disease rate;mortality;Mus;Mutation;Nature;novel;novel therapeutics;Organ;Organism;pathogen;Pathogenesis;Pathology;Pathway interactions;Peptide Initiation Factors;Phagocytosis;Phase;Pneumonia;Population;Process;Research;Research Personnel;Resistance;resistance mechanism;response;screening;Sepsis;Site;skills;socioeconomics;Spleen;Splenic Red Pulp;Splenocyte;success;Systemic infection;Testing;therapeutic target;Tissues;Training;transposon sequencing;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Defining macrophage defense during Klebsiella pneumoniae bacteremia

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: COLUMBIA

ORG_STATE: SC

PHR: Repetitive, mild traumatic brain injury is increasing seen in soldiers deployed to combat areas and linked to persistent, debilitating neurological symptoms in Veterans. Currently, only supportive therapies exist and pharmacotherapies that improve neurological function years after the initiating event are desperately needed. We are developing nanomaterials for delivery of therapeutics to the brain. With this approach we aim to reverse neurological injuries like those linked to traumatic brain injury. If successful, the work could put forth the first pharmacotherapy for Veterans suffering from debilitating symptoms that persist in the years following the initiating brain injury.

PI_NAMEs: GOWER, ROBERT MICHAEL (contact)

PROJECT_TERMS: Address;Adult;Age Months;Alzheimer's disease model;Anti-Inflammatory Agents;Area;Atrophic;Autopsy;Award;axon injury;Benchmarking;Brain;brain health;Brain Injuries;Brain Pathology;Brain region;Caring;Cells;cerebral atrophy;Chronic Phase;chronic traumatic encephalopathy;clinical translation;Cognition;cognitive testing;combat;debilitating symptom;Deposition;Diffuse;Diffuse Axonal Injury;Drug Carriers;Drug Delivery Systems;Drug Formulations;Drug Prescriptions;efficacy testing;Event;Exhibits;FDA approved;General Population;Genes;Genetic Transcription;Gliosis;head impact;Histology;Histopathology;Human;Impaired cognition;Impairment;improved;information processing;Learning;Link;Location;Maintenance;Memory;Mental Health;mild traumatic brain injury;Modeling;Molecular;Mus;nanomaterials;nanoparticle;nanoparticle drug;Nerve Degeneration;Nervous System Physiology;Nervous System Trauma;neuroinflammation;Neurologic Symptoms;Neuromodulator;Neuronal Plasticity;Neurons;neuropathology;neuroregulation;Nose;novel;novel therapeutics;object recognition;Outcome;Pathogenicity;Pathologic;Pathology;Performance;persistent symptom;Pharmacotherapy;Pharmacy (field);Pilot Projects;Proteins;Quality of life;Retinoic Acid Receptor;Rodent;Rodent Model;Role;Route;Saline;Schedule;Secondary to;Self Administration;Series;sex;Soldier;stem cell proliferation;Supportive care;Symptoms;System;Testing;Therapeutic;Thinking;Traumatic Brain Injury;Tretinoin;United States;Veterans;Vitamin A;white matter;Work

PROJECT_TITLE: Improving cognition in the chronic phase of traumatic brain injury with nanoparticles for nose-to-brain drug delivery

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Alzheimer disease (AD) is the leading cause of dementia and characterized by pathology beginning in hippocampus and adjacent brain regions implicated in memory. Among the memory impairments are social cognition memories that allow us to recognize and discriminate familiar individuals. These memory traces may be stabilized by extracellular matrix structure, perineuronal nets (PNNs) that surround hippocampal neurons and we found these to be disrupted in AD and hypothesize that proteolysis of PNNs in hippocampus are causal of social memory decline in AD.

PI_NAMEs: SONTHEIMER, HARALD W (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Address;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;Animals;Anterior;Astrocytes;astrogliosis;Autopsy;behavioral study;Brain;Brain region;brain tissue;Candidate Disease Gene;candidate identification;cell type;Chondroitin ABC Lyase;Clinical;Dementia;Encapsulated;Encephalitis;Ensure;entorhinal cortex;Enzymes;Excision;experimental study;extracellular;Extracellular Matrix;gamma-Aminobutyric Acid;Genes;Growth;hippocampal pyramidal neuron;Hippocampus;Histocytochemistry;Human;human disease;Impairment;In Situ;Individual;Inflammation;inhibitor;inhibitory neuron;Injections;Lateral;Learning;life span;LoxP-flanked allele;Maintenance;MAPK8 gene;Matrix Metalloproteinases;Measures;Memory;Memory impairment;Memory Loss;memory recognition;Microglia;Molecular;mouse model;Mus;Neurofibrillary Tangles;Neurons;normal aging;novel;Paper;patch clamp;Pathologic;Pathology;Peptide Hydrolases;Phenocopy;Phenotype;Play;Population;pre-clinical;prevent;Process;Proteoglycan;Proteolysis;Pyramidal Cells;Reactive Inhibition;receptor;receptor density;Reporting;Resolution;Role;social;social cognition;spatiotemporal;STAT3 gene;Structure;Synapses;Synaptic Receptors;tau Proteins;tau-1;Three-dimensional analysis;Time;timeline;Tissues;transcriptome;Tyrphostins;uptake

PROJECT_TITLE: Extracellular matrix and memory impairments in Alzheimer disease

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of liver pathologies from simple steatosis to nonalcoholic steatohepatitis (NASH; hepatic inflammation and fibrosis) and cirrhosis. This condition is an important issue for the VA healthcare system considering the increased liver-related, cardiovascular disease, and all-cause mortality associated with progression to NASH. This study will examine the novel relationship between endothelial nitric oxide synthase (eNOS) and the regulation of hepatic de novo lipogenesis in the development of NAFLD and a novel role for eNOS in the activation of Kupffer cells and hepatic stellate cells in the development and progression of NASH. The outcomes of this study will improve our understanding about the mechanisms responsible for NASH development and progression and highlight potential therapeutic targets for the future treatment of NASH.

PI_NAMEs: RECTOR, RANDY SCOTT (contact)

PROJECT_TERMS: Acetyl-CoA Carboxylase;Actins;ADD-1 protein;Adult;Affect;Anti-Inflammatory Agents;Attenuated;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Cirrhosis;Clinical;Collagen;cytokine;Data;Development;Disease;Epidemic;Fatty Liver;Fatty-acid synthase;Fibrosis;Future;gain of function;genetic regulatory protein;Genetic Transcription;Growth Factor;Health;Healthcare Systems;Hepatic;Hepatic Stellate Cell;Hepatocyte;Histologic;Human;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;Injections;innovation;insight;Investigation;Knockout Mice;Kupffer Cells;lipid biosynthesis;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;loss of function;Macrophage;Mediating;Military Personnel;military veteran;mortality;Mus;Myofibroblast;Nitric Oxide;Nitric Oxide Donors;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;NOS3 gene;novel;Obesity;Outcome Study;overexpression;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Population;Post-Translational Regulation;Predisposition;Prevalence;Primary carcinoma of the liver cells;Production;Regulation;Reporting;Rodent;Role;Severities;simple steatosis;Small Interfering RNA;Smooth Muscle;Testing;therapeutic target;transcription factor;Up-Regulation;Veterans;western diet

PROJECT_TITLE: Hepatic eNOS in the regulation of NASH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDA-L (01)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Asthma;Biotechnology;Chronic Obstructive Pulmonary Disease;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: NUPEAK THERAPEUTICS, INC.

PHR: Narrative Respiratory airway diseases are one of the most common maladies of mankind and may be life-threatening in the form of asthma and chronic obstructive pulmonary disease (COPD). At present, there are no specific, effective, and safe drugs to fully correct the underlying basis for these diseases. The proposed development of a new type of drug to precisely attack the root cause of these conditions will thereby address an unmet need for a major public health problem.

PI_NAMEs: BROSCHAT, KAY O (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Airway Disease;airway inflammation;Allergens;Animal Model;animal safety;Antibodies;Asthma;Attributes of Chemicals;Award;Basal Cell;Binding;Biological Markers;Biotechnology;Canis familiaris;cell growth;Cell model;Cell Reprogramming;Cells;Chemistry;Chronic Obstructive Pulmonary Disease;Clinical Trials;Clinical Trials Design;commercialization;Continuity of Patient Care;Contracts;COVID-19;cytokine;Data Analyses;Data Set;design;Development;Disease;disease model;disease phenotype;Dose;drug candidate;Drug Design;drug development;Drug Kinetics;Engineering;Enzyme Inhibition;epithelial stem cell;Exhibits;Formulation;genotoxicity;Goals;Human;human model;immune activation;immune cell infiltrate;In Vitro;in vivo;Incubators;Inflammatory;Inhalation;inhibitor;Intravenous;Investigational Drugs;kinase inhibitor;Kinetics;lead candidate;Legal patent;Licensing;Life;Link;Long COVID;Lung;Lung Diseases;manufacture;manufacturing organization;MAPK13 gene;Marketing;Missouri;Mitogen-Activated Protein Kinases;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Mucous body substance;National Heart, Lung, and Blood Institute;Orphan;Pathway interactions;patient population;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;Phosphotransferases;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;preclinical study;Privatization;Process;Production;programs;Public Health;Rattus;Recommendation;Regimen;Resources;respiratory;respiratory virus;response;Safety;Signal Transduction;Small Business Technology Transfer Research;small molecule;Structure;Technology;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Toxic effect;Toxicology;Toxin;translation to humans;translational approach;Universities;Viral;Virus Diseases;Washington

PROJECT_TITLE: A New Small-Molecule Kinase Inhibitor for Airway Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative  A generalized deficit in motivation is a behavioral symptom associated with mental health disorders. However, standard assays of motivation are not capable of tracking deficits in motivation across multiple reward options in a single setting. This proposal will use a novel assay of motivation to identify the neural signals responsible for generalized motivational deficits and to implement rational strategies to reverse these motivation impairments.

PI_NAMEs: WANAT, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Animals;associated symptom;behavioral response;Behavioral Symptoms;Biological Assay;Categories;Data;Decision Making;Dopamine;dopamine system;Exhibits;experimental study;Exposure to;Goals;Impairment;Mediating;Mental disorders;Modeling;Motivation;neurotransmission;novel;Nucleus Accumbens;optogenetics;Pattern;Photometry;Rattus;Reinforcement Schedule;response;restoration;Rewards;Rodent;Schedule;Signal Transduction;Testing;Training;Update;Work

PROJECT_TITLE: Neural signals controlling generalized deficits in motivation

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


FUNDING_MECHANISM: OTHERS

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Melanoma is an aggressive skin cancer and the fifth most common cancer in the US population. US Veterans are particularly impacted by skin cancer because of radiation and UV exposure. Most melanomas are diagnosed at an early, localized stage, but approximately 10-15% of these melanomas eventually metastasize despite appropriate treatment. This progression of localized melanoma to metastatic disease is a leading cause of morbidity and mortality. No treatment exists for melanoma patients who are at high risk of future metastasis, but whose clinical stage does not qualify for existing adjuvant treatments. Preliminary data suggests that use of statins, a class of cholesterol medication, may decrease melanoma metastasis. This study will evaluate the relationship between statin use and melanoma outcomes from multiple angles and generate data that could lead to a decisive clinical trial and to the first treatment to prevent metastasis of genetically high-risk melanoma.

PI_NAMEs: YU, WESLEY Y (contact)

PROJECT_TERMS: Adjuvant Therapy;Angiopoietin-2;Animal Model;Benign;Biometry;bisphosphonate;cancer initiation;Cell Adhesion;Cell Line;Cholesterol;Clinical;clinical data repository;clinical practice;Clinical Trials;cohort;Complement;cooperative study;cost;cost effective;Cutaneous;Data;Data Set;data warehouse;Death Rate;design;Diagnosis;Disease;Distant Metastasis;Dose;drug discovery;drug repurposing;efficacy evaluation;Enzymes;Etiology;Foundations;Funding;Future;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic variant;Germ Lines;Growth Factor;Guidelines;Health Care Costs;high risk;hydrophilicity;Immune response;immunogenicity;improved;In Vitro;inhibitor;innovation;Intervention Trial;Link;lipophilicity;lymph nodes;Lymphangiogenesis;Lymphatic Vessel Tumors;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma patient;Mendelian randomization;Metastatic Melanoma;metastatic process;Methods;mevalonate;military veteran;Molecular;Morbidity - disease rate;mortality;Neoplasm Metastasis;novel therapeutics;Oncology;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Population;prevent;Prevention;Preventive;programs;Property;protein function;Radiation exposure;randomized, clinical trials;RAS inhibition;Research Proposals;Retrospective cohort;Risk;Safety;side effect;Skin Cancer;Statistical Methods;Techniques;Testing;therapy design;Time;Translating;Tumor Cell Migration;tumor progression;United States National Institutes of Health;UV Radiation Exposure;Variant;Vascular Endothelial Growth Factor C;Veterans;Work

PROJECT_TITLE: BOOST:Better Oncology Outcomes Through Statin Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCE-A (01)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative PDA ligation is a life-saving intervention for some extremely preterm infants but is associated with severe post- interventional cardiorespiratory instability [Post-Ligation Cardiac Syndrome (PLCS)] due to impaired heart function, which may lead to death, bronchopulmonary dysplasia, or neurodevelopmental impairment at 2 years of age. In many centers PLCS is recognized late, when hypotension is severe, prompting use of harmful vasopressor drugs (increase afterload); however, preliminary evidence suggests that prophylactic use of intravenous milrinone (decrease afterload) decreases the risk of PLCS. This randomized trial is designed to evaluate whether a preemptive approach to milrinone treatment will reduce the risk of death or postinterventional cardiorespiratory deterioration. By mitigating the risk of PLCS, patients will require have decreased duration of postinterventional ventilation, and decreased risk of bronchopulmonary dysplasia and adverse neurodevelopmental outcome. Of note, this trial will be the first and only randomized trial of milrinone in premature infants to appraise both short and long-term treatment safety.

PI_NAMEs: BELL, EDWARD F;MCNAMARA, PATRICK J (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: 2 year old;Adult;Biological;Bronchopulmonary Dysplasia;Cardiac;Cardiac Catheterization Procedures;Cardiopulmonary;Cardiovascular system;cerebral hypoperfusion;Cessation of life;Chronic lung disease;Clinical;clinical center;clinical practice;Clinical Treatment;Clinical Trials;Conduct Clinical Trials;congenital heart abnormality;Cyclic AMP;Data;Data Coordinating Center;design;Deterioration;Development;Devices;early childhood;economic cost;efficacy evaluation;Enrollment;Ensure;Environment;evidence base;expectation;extreme prematurity;Extremely Low Birth Weight Infant;Functional disorder;Funding;Gestational Age;Goals;Health;Heart failure;heart function;hemodynamics;Home;Hydrolysis;Hypertension;Hypotension;Impairment;improved;improved outcome;Incidence;indexing;Infant;innovation;insight;Intervention;Intravenous;intravenous administration;Knowledge;Left;Left Ventricular Function;Life;Ligation;Low Cardiac Output;lung injury;Masks;Milrinone;Mission;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Myocardial dysfunction;Myocardium;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;neonatal outcome;neonate;Neonatology;Neurodevelopmental Disability;Neurodevelopmental Impairment;novel strategies;Observational Study;Operative Surgical Procedures;Outcome;Oxygen Therapy Care;Parents;Patent Ductus Arteriosus;Patients;Pharmaceutical Preparations;Pharmacology;Phosphodiesterase Inhibitors;Physiological;post intervention;Postoperative Period;Predisposition;Pregnancy;premature;Premature Infant;prevent;Prevention;prophylactic;Prophylactic treatment;prospective;Publishing;randomized placebo controlled trial;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Research Personnel;respiratory;Risk;Risk Factors;risk mitigation;Risk Reduction;Safety;Scientist;Secondary to;Site;Survivors;Syndrome;Testing;Therapeutic;Translating;Treatment Efficacy;United States;Vascular Smooth Muscle;Vasoconstrictor Agents;Vasodilator Agents;ventilation;Ventricular;Work

PROJECT_TITLE: 1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) – CCC

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (OA)]


ORG_STATE: CA

PHR: Thyroid hormone (TH) is essential for brain development and for normal brain function in the adult. Traumatic brain injury (TBI) has a high prevalence among the Veteran population, up to 20%, with associated morbidity and mortality. TBI is associated with reduced levels of thyroid hormone (TH) in the serum as well as in the brain. In rodent TBI models, treatment with TH shortly after injury, has been shown to protect the brain from injury, reduce brain edema and promote recovery. In a cell culture model of neuronal damage from low oxygen, which occurs in TBI, TH treatment protects from injury and promotes neuronal regeneration. Understanding the mechanisms of thyroid hormone protection of neuronal injury and the pathways activated could have important applications to limit brain injury and promote recovery in Veterans.

PI_NAMEs: BRENT, GREGORY A (contact)

PROJECT_TERMS: Adult;Animal Model;Anti-Inflammatory Agents;Area;Brain;brain cell;Brain Edema;Brain Injuries;Brain region;Cell Culture Techniques;Cell Death;Cell Line;Cell membrane;Cell model;cell motility;cell type;Cells;Cellular Stress;Clinical;Clinical Research;Coculture Techniques;controlled cortical impact;Controlled Study;cytokine;Data;Development;DNA Methylation;Edema;Enzymes;Epigenetic Process;epigenetic regulation;Equilibrium;Exposure to;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;genome wide methylation;genome-wide;Glial Cell Proliferation;gliogenesis;Goals;Heterogeneity;High Prevalence;histone methylation;histone modification;hormone therapy;Hour;Hypoxia;Image;Impairment;in vitro Model;in vivo;Individual;Inflammation;inhibitor;Injury;Iodide Peroxidase;Lesion;Link;Location;Maps;Mediating;Metabolic;Metabolism;Methylation;Microglia;migration;military veteran;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Natural regeneration;Nerve Regeneration;Neuroglia;neuron loss;neuron regeneration;Neuronal Differentiation;neuronal growth;Neuronal Hypoxia;Neuronal Injury;Neurons;neuroprotection;novel;Nuclear Receptors;Oxygen;Parietal Lobe;pathogen;Pathogenesis;Pathway interactions;Peripheral;Phagocytosis;Phenotype;Population;Process;progenitor;Proliferating;protective effect;Recovery;response;response to brain injury;Rodent;Rodent Model;Role;Serum;Specimen;stem cell differentiation;stem cell migration;stem cell proliferation;System;therapeutic target;Thyroid Hormone Receptor;Thyroid hormone receptor alpha;Thyroid Hormones;Thyrotropin;Thyroxine;Time;tissue repair;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery;Triiodothyronine;uptake;Veterans;whole genome;XCL1 gene

PROJECT_TITLE: Thyroid Hormone and Neuronal Protection


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Existing behavioral postpartum weight interventions have largely failed to produce substantial improvements in maternal cardiometabolic health in part due to high participant burden and failure to address the psychological needs (e.g., fatigue) and competing demands (e.g., childcare) of postpartum women. Early time-restricted eating focuses on a single target behavior (i.e. timing of intake), making it a straightforward dietary approach which may confer benefits behaviorally (e.g., improved adherence) and physiologically (e.g., improved insulin sensitivity) that are especially relevant postpartum. This project will test the feasibility of such an intervention, which can then be tested in an adequately powered R01 randomized controlled trial.

PI_NAMEs: WORTHINGTON, CAMILLE SCHNEIDER (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adipose tissue;Adult;Adverse effects;adverse outcome;Alabama;Applications Grants;arm;Attention;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Body Composition;Body mass index;Body Weight decreased;Caloric Restriction;Calories;cardiometabolism;Child;Child Care;Chronic Disease;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;Clinical effectiveness;Clinical Investigator;cohort;Control Groups;cost effectiveness;Data;design;Desire for food;Development;Diet;dietary;dietary approach;Doctor of Philosophy;Eating;Energy Intake;Energy Metabolism;experience;Face;Failure;Fasting;Fatigue;Fatty acid glycerol esters;feasibility testing;Feedback;Food;Future;Goals;Grant;Health;high risk;Hour;Hunger;improved;increased appetite;Infant;Institution;Insulin Resistance;insulin sensitivity;Intake;Intermittent fasting;Intervention;intervention refinement;Knowledge;lipid biosynthesis;Maternal and Child Health;Measures;Mentors;Mentorship;Metabolic;Metabolism;Methodology;novel;novel strategies;nutrition;Obesity;Outcome;Overweight;Oxidative Stress;Participant;Patient Outcomes Assessments;Physical activity;Physiological;postpartum health;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;prepregnancy;programs;Protocols documentation;psychologic;Qualitative Research;randomized trial;Randomized, Controlled Trials;recruit;reduced food intake;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk;Site;skills;Sleep disturbances;standard care;stressor;success;Testing;Time;Time-restricted feeding;Training;trial design;Universities;Visceral;Weight;Weight Gain;Weight maintenance regimen;Woman

PROJECT_TITLE: Use of early time-restricted eating to promote weight loss and improve cardiometabolic health in postpartum women

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: The major objective of this research project is to determine whether molecular mediators, generated by injured peripheral nerves or genetically engineered to bind the low-density lipoprotein receptor related protein (LRP1), regulate Schwann cell physiology, and prevent the development of painful peripheral neuropathy. We hypothesize that activation of Schwann cell LRP1 will limit neuroinflammation in DRGs and change the cellular landscape of peripheral nerves induced by toxic chemotherapy drugs. Identifying novel activators of the SC Repair Program will provide innovative strategies for treating painful peripheral neuropathies which is highly prevalent in veterans.

PI_NAMEs: CAMPANA, WENDY M. (contact)

PROJECT_TERMS: Acceleration;Acute;Acute Pain;addiction;Address;Affect;afferent nerve;Afferent Neurons;Agonist;American;anti-depressive agents;Anti-Inflammatory Agents;Anticonvulsants;Award;Axon;Behavior;Binding;Cancer Survivor;cancer therapy;Cell Physiology;Cell Survival;Cells;chemotherapeutic agent;chemotherapy;Chronic;chronic neuropathic pain;chronic pain;chronic pain management;COVID-19;curative treatments;Cutaneous;Data;debilitating pain;design;Development;Dose;early experience;early onset;Etiology;Event;Funding;Gene Expression;General Population;Genetic;Genetic Engineering;Goals;Healthcare;Human;Immune;improved;improved outcome;Incidence;Inflammatory;inflammatory pain;injured;Injury;innovation;Laboratories;laboratory development;Laboratory Research;LDL-Receptor Related Protein 1;Lead;Ligands;Link;Local Anesthetics;Measures;Mediator;Metabolic;Migration Assay;military service;military veteran;Modality;Modeling;Molecular;mouse model;Mus;Nerve;Nerve Fibers;nerve repair;Nervous System Physiology;Nervous System Trauma;Neuroglia;neuroinflammation;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 3;Neurotrophin 3;Nociception;non-opioid analgesic;novel;Opioid;Paclitaxel;Pain;Pain management;pain outcome;pain reduction;painful neuropathy;pandemic disease;Paresthesia;Pathogenesis;Patients;Peptides;Peripheral;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phenotype;Play;prevent;Process;programs;Property;Proteins;Proteomics;Publishing;Quality of life;receptor;receptor binding;repaired;Reporting;Research;Research Design;Research Project Grants;research vision;Resources;response;response to injury;Role;Schwann Cells;Sensory;service programs;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site-Directed Mutagenesis;Steroids;Stress;Symptoms;System;Testing;Therapeutic;Toxicant exposure;Transactivation;translational potential;transmission process;Traumatic injury;Veterans;Work

PROJECT_TITLE: Targeting LRP1 in Neuroinflammation and Neuropathic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURP-N (01)]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative As our knowledge about brain pericytes and their functions in CNS diseases grow tremendously in the last decade, the lack of specific marker or genetic tools for brain pericytes has become a major hurdle in the field to key questions such as brain pericyte's heterogeneity. We have developed new genetic tools based on a brain pericyte specific marker Atp13a5, and found interesting heterogeneity of brain pericytes between regions inside and outside the blood brain barrier (BBB). Therefore, we propose to further investigate the genetic and functional difference between BBB pericytes and non-BBB pericytes using our new genetic tools based on the Atp13a5 model, and understand their changes associated with aging and Alzheimer's disease.

PI_NAMEs: ZHAO, ZHEN  (contact)

PROJECT_TERMS: Address;Age Months;age related neurodegeneration;Aging;alanine aminopeptidase;Alzheimer's Disease;Amyloid;Anatomy;Antibodies;apolipoprotein E-4;Atlases;Basement membrane;Benchmarking;Biological;Biology;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier function;Brain;brain based;Brain Mapping;brain pericytes;Brain region;Cells;Central Nervous System;Central Nervous System Diseases;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;data mining;Data Set;Development;Disease;Disease Progression;early onset;Embryonic Development;Female;gene-targeted therapy;Genetic;Genetic Markers;Genetic Models;Genetic Screening;genome wide screen;Goals;Health;Heterogeneity;Histologic;Hypoxia;improved;Injury;insight;Knock-in;Knock-in Mouse;Knowledge;Location;Maintenance;male;Maps;Modeling;Molecular;molecular marker;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;normal aging;novel;novel marker;Organ;Outcome;Pathway interactions;Pericytes;Peripheral;Pineal gland;Pituitary Gland;Play;Population;Process;regional difference;Reporter;Reporter Genes;Research;Structure of choroid plexus;System;Testing;Time;Tissues;tool;Toxic effect;Transcript;transcriptome;transcriptomics;Transgenic Model;Transgenic Organisms;Traumatic Brain Injury

PROJECT_TITLE: Probing the heterogeneity of brain pericytes using new genetic tools

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


PHR: Obstructive sleep apnea (OSA) is the most prevalent service-connected disability of all the respiratory disabilities for which Veterans receive benefits. Between 2015-2018, OSA burden has increased from 664,000 to 1.3 million Veterans, generating nearly $234 million in sleep apnea supply cost, despite fewer than 50% of Veterans using continuous positive airway pressure (CPAP) devices as prescribed. There are multiple mechanisms underlying sleep apnea pathogenesis, each of which may be amenable to tailored treatment beyond CPAP alone. The purpose of this proposal will be to identify the mechanisms underlying an understudied mode of pharyngeal collapse called negative effort dependence. This work will pave a path towards individualized Veteran sleep care based on individual physiology.

PI_NAMEs: NOKES, BRANDON THOMAS (contact)

PROJECT_TERMS: Age;Air Movements;Anatomy;Arousal;attenuation;Biometry;Body mass index;Breathing;Cardiac;cardiometabolism;career development;Caring;Catheters;Chest;Clinical;Clinical Trials Design;Compensation;Continuous Positive Airway Pressure;cost;Critical Care;Data;Dependence;Development;Development Plans;Devices;Dilator;disability;Elderly;Electric Stimulation;Electromyography;esophagus pressure;Event;Exhibits;Failure;Foundations;Funding;Future;genioglossus muscle;Head;High Prevalence;Hypoglossal nerve structure;Hypoxemia;Impairment;improved;Individual;individualized medicine;International;Intervention;Investigation;Liquid substance;Lung;Measures;Mechanics;Mentors;Modeling;Muscle;neural;Neurobiology;Neurocognitive;novel strategies;Obesity;Obstructive Sleep Apnea;Outcome;Output;Pathogenesis;Patient Focused Care;Patients;Persons;Pharmaceutical Preparations;Pharyngeal structure;Physicians;Physiological;Physiology;Polysomnography;pressure;Pulse Pressure;Pump;Reflex action;Research;research and development;respiratory;Respiratory physiology;response;Risk;Risk Factors;Role;Science;Scientist;Services;signal processing;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;statistics;Sturnus vulgaris;targeted treatment;Testing;Therapeutic;Time;Training;trait;Veterans;Vision;Work

PROJECT_TITLE: The Role of Negative Effort Dependence as a Targetable Mechanism of Upper Airway Collapse in Sleep Disordered Breathing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PULM-T (01)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: PROJECT NARRATIVE Youth with early juvenile justice involvement engage in high rates of problematic cannabis use; however, existing intervention approaches to address this issue are either overly intensive in nature or not designed for the unique needs of youths in the juvenile justice system (e.g., addressing concurrent HIV/STI risk behaviors and/or delinquency). The proposed study will provide important data on the acceptability, feasibility, and initial efficacy of an adapted modular and personalizable family-based intervention for cannabis use among early justice-involved youth. The proposed project also has implications for the effective development of substance use interventions which can be implemented as part of a continuum of care within the juvenile justice system.

PI_NAMEs: SHEERIN, KAITLIN  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: acceptability and feasibility;Adaptation research;Address;Adolescent;adolescent substance use;Cannabis;Caregivers;Categories;Child Rearing;Chronic;Clinical;Clinical Trials Design;Communities;Competence;condoms;Continuity of Patient Care;court;Data;Data Analyses;Development;Dropout;Early Intervention;Enrollment;Ethics;Evaluation;evidence base;Evidence based intervention;experience;Family;Feedback;follow up assessment;follow-up;Goals;HIV/STD;Hospitals;improved;Intervention;Intervention Studies;Interview;Justice;juvenile justice system;K-Series Research Career Programs;Link;marginalized community;marijuana use;Measures;Mentors;Mentorship;Methodology;Modeling;motivational enhancement therapy;National Institute of Drug Abuse;Nature;Outcome;Parents;patient oriented;peer;Personal Satisfaction;Phase;Population;primary caregiver;programs;Protocols documentation;psychoeducation;Qualitative Methods;Randomized;randomized, clinical trials;rearrest;recidivism;Recording of previous events;recruit;Research;Research Project Grants;Rhode Island;Risk;Risk Behaviors;Risk Reduction;Role;Services;skills;Social support;Strategic Planning;substance use;substance use prevention;Supervision;System;Systemic Therapy;telehealth;Testing;Time;Training;Treatment Efficacy;Treatment Protocols;Universities;user centered design;Withdrawal;Work;Youth

PROJECT_TITLE: Brief Family-Based Cannabis Use Intervention for Youth with Early Juvenile Justice Involvement

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


PHR: The human brain makes and releases endocannabinoids in order to allow the body to perform certain tasks. The internal detection system for the endocannabinoids is present in a large fraction of human nerve cells and can also be used by drugs like cannabis. Cannabis and related drugs have been increasingly used by US Veterans to try and treat several diseases including chronic pain, epilepsy, and posttraumatic stress disorder. Unfortunately, cannabis and related drugs also cause unwanted side effects that limit their usefulness. Cannabis and related drugs appear to have several actions on nerve cells but the relative strength of the different actions is not understood. In this proposal, we describe how we will increase our understanding about the various actions of endocannabinoids and cannabis-related drugs on individual nerve cells. By characterizing these drug actions, we will determine which represent plausible targets for new drugs that will improve the treatment of important diseases experienced by Veterans.

PI_NAMEs: SMITH, STEPHEN M (contact)

PROJECT_TERMS: Action Potentials;Adverse drug effect;Adverse effects;Affect;Agonist;anandamide;Animals;Award;Behavior;Brain;Calcium Channel;Calcium Signaling;Calcium-Sensing Receptors;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis;Central Nervous System;Characteristics;chronic pain;clinically relevant;CNR1 gene;Collaborations;Data;detection platform;Disease;Dissection;drug action;Drug usage;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Epilepsy;excitatory neuron;Excitatory Synapse;exogenous cannabinoid;experience;experimental study;Frequencies;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;genetic approach;Glutamates;Goals;Human;improved;Incidence;Individual;inhibitory neuron;Inhibitory Synapse;interest;Ion Channel;Label;Legal;Lipids;lysophosphatidylinositol;marijuana use;marijuana use disorder;Mediating;Methods;military veteran;Mission;Motor Activity;Mus;mutant;Mutant Strains Mice;Neocortex;neocortical;Nerve;Nervous System;Neural Pathways;neuronal cell body;neuronal excitability;Neurons;Neurotransmitters;new therapeutic target;Nociception;novel therapeutics;Pain;Pain management;patch clamp;Patch-Clamp Techniques;Patients;Pharmaceutical Preparations;pharmacologic;Post-Traumatic Stress Disorders;postsynaptic;pre-clinical;Preparation;presynaptic;Property;Protein Biochemistry;receptor;Recreational Drugs;Reporter;Research Support;Resolution;Role;Seizures;Shapes;side effect;Signal Transduction;Site;Sleep;Sodium Channel;Specificity;Synapses;synaptic depression;synaptic function;synaptic inhibition;Synaptic plasticity;Synaptic Transmission;synthetic cannabinoid;Temperature;Testing;Therapeutic;Therapeutic Effect;Vesicle;Veterans;voltage;voltage clamp

PROJECT_TITLE: Cannabinoid signaling in the neocortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURA-N (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative In the United States, one in three older adults in the U.S. dies with or from dementia, a progressive serious illness causing significant public health burden. Yet there are inequities in access to and quality of hospice care at end-of-life among Black, Latinx, and Asian Americans with dementia. This study aims to use multiple methods to generate data on current experiences with and preferences for dementia hospice care and (in collaboration with former caregivers, hospice and dementia experts, and policymakers) generate a prioritized list of recommendations for improving hospice care for racial and ethnic minoritized people with dementia and their families.

PI_NAMEs: HARRISON, KRISTA LYN (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: access disparities;Address;Alzheimer's Disease;Alzheimer's disease related dementia;American;Asian Americans;barrier to care;Behavioral Symptoms;Black race;Caregivers;Caring;Case Study;Censuses;Clinical Management;clinical practice;Cohort Studies;Collaborations;Communities;Complex;cost;Data;data integration;Dementia;Development;Discrimination;end of life;end of life care;Enrollment;Equity;Ethics;ethnic minority;ethnic minority population;experience;Family;federal policy;Focus Groups;Geography;Goals;Guidelines;Home;Hospice Care;hospice environment;improved;Inequity;Interview;Knowledge;Language;Latinx;lens;Life Experience;Literature;Measures;Medicare;meetings;Methods;Minority;Minority Groups;Modeling;older adult;Organizational Ethics;Ownership;Pacific Islander;Palliative Care;Personal Satisfaction;Persons;Policies;Policy Maker;policy recommendation;preference;Process;Prognosis;Provider;Public Health;Publishing;Qualitative Methods;Quality of Care;racial minority;racial minority population;racism;Recommendation;recruit;Research;Research Design;Research Personnel;Research Support;Role;Services;standard care;Structural Racism;Structure;Supportive care;Surveys;symptom management;Underserved Population;United States;Variant;Work

PROJECT_TITLE: Improving hospice care for racial and ethnic minoritized older adults with Alzheimer’s Disease and Related Dementias (ADRD)

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PHR: Public Health Relevance Our overall goal is to improve patient outcomes through development and evaluation of novel sequencing strategies in order to facilitate early, appropriate drug-resistant tuberculosis treatment under programmatic conditions, and to preserve new shorter course treatment regimens for drug-resistant tuberculosis.

PI_NAMEs: ENGELTHALER, DAVID M;METCALFE, JOHN ZAPATA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Base Sequence;Biological Assay;Clinic;Clinical;Clinical Management;Cluster randomized trial;cohort;Collaborations;Communities;cost;cost efficient;Data;deep sequencing;design;Detection;Development;diagnostic strategy;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;effective therapy;efficacy evaluation;Epidemic;Evaluation;evidence base;fighting;Funding;genome sequencing;genomic locus;genomic tools;Genomics;Geographic Locations;Geography;Goals;HIV;HIV/TB;improved;individualized medicine;industry partner;ineffective therapies;Infrastructure;innovation;International;Intervention Trial;Investigation;Laboratories;life span;Liquid substance;minimal inhibitory concentration;Modernization;Molecular;Monitor;Mycobacterium tuberculosis;nanopore;next generation sequencing;Nonprofit Organizations;novel;Oral;Outcome;pathogen genomics;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Population;population based;portability;Predisposition;preservation;pressure;prospective;Public Health;public health relevance;Pyrazinamide;rapid detection;rapid test;Reference Standards;Regimen;Resistance;Resistance profile;Resolution;Resources;Rifampicin resistance;Risk;Sampling;scale up;sequencing platform;South African;Specimen;Sputum;standard of care;Swab;targeted sequencing;Technology;Testing;Time;tool;Translating;transmission process;Treatment outcome;Treatment Protocols;trend;Tuberculosis;tuberculosis diagnostics;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Validation;Variant;whole genome;Work

PROJECT_TITLE: Handheld and population-based sequencing for rapid detection of new and repurposed drug resistance in M. tuberculosis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Some individuals with intellectual and developmental disabilities engage in self-injurious behavior (SIB), which can result in injuries, disfigurement, and loss of function (e.g., blindness). Our research on the least understood type of SIB showed it was actually comprised of subtypes, including some that did not respond well to currently available treatments. With further study, we gained insight into how the subtypes differed, pilot tested novel-treatment procedures, and are now positioned to conduct a clinical trial evaluating an intensive treatment approach targeting the most treatment- resistant subtypes.

PI_NAMEs: HAGOPIAN, LOUIS P. (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Address;Attention;Behavior;Behavior Therapy;Biological;Blindness;Clinical;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Crossover Design;Data;Data Analyses;Data Set;design;Devices;effective intervention;Effectiveness;Equipment;experience;Impairment;Individual;Injury;Inpatients;insight;Intellectual functioning disability;Intervention;Laws;Literature;loss of function;Methods;National Institute of Child Health and Human Development;novel;Patient Admission;Persons;Phase;pilot test;Positioning Attribute;Procedures;programs;Psychological reinforcement;Randomized;Reinforcement Schedule;reinforcer;Research;Research Support;Resistance;restraint;Self-control as a personality trait;Self-Help Devices;Self-Injurious Behavior;skills;Social Reinforcement;Source;standard of care;Standardization;Stimulus;success;Toy;Training

PROJECT_TITLE: A Clinical Trial for Treatment-Resistant Subtypes of Self Injury

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Delusions are impairing and distressing transdiagnostic psychotic symptoms that require better treatments. Longitudinal assessment of delusion severity and proposed cognitive alternations will advance mechanistic models, informing treatment development. This project will be the first to determine how proposed cognitive abnormalities in belief updating change over time during recovery from a psychotic episode, clarifying their role in delusion severity.

PI_NAMEs: SHEFFIELD, JULIA MAY (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Address;Area;arm;Behavior;Belief;Brain;career;career development;Clinical;clinical translation;Cognitive;Cognitive deficits;cognitive neuroscience;cognitive task;cohort;comparison group;computational neuroscience;Computer Models;Corpus striatum structure;Cross-Sectional Studies;Data Analyses;Delusions;Development;Development Plans;Diagnostic;Dimensions;Distress;emotional distress;expectation;experience;Functional impairment;Functional Magnetic Resonance Imaging;Future;Goals;Hospitalization;ideation;Impairment;improved;Individual;Inpatients;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Licensing;Life;longitudinal course;Maintenance;Measurement;Measures;Mediating;Mediation;Mentors;Mentorship;Methods;Modeling;Neurobiology;Neurocognitive;neuroimaging;Neuropsychology;novel;Outpatients;Participant;patient oriented;Patients;Population;Prefrontal Cortex;Process;programs;Psychiatric Hospitals;Psychiatry;Psychologist;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Quality of life;Recovery;recruit;Research;Research Design;Resistance;response;Role;Schizophrenia;Sensory;Severities;Site;skills;statistics;Symptoms;targeted treatment;Techniques;Testing;theories;therapy development;Thinking;Time;Training;trait;Translational Research;Uncertainty;Update;Ventral Striatum;Violence;Work

PROJECT_TITLE: Cognitive mechanisms of delusion severity throughout recovery from an acute psychotic episode: a computational approach

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]