NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PHR: Project Narrative. This R01 study will advance our understanding of the neurobiological impact of early life stress and its impact on risk of psychopathology during the neurodevelopmentally sensitive period of early childhood. Our neurobiological and developmental model will help identify biological profiles that signal risk during a period of heightened brain plasticity and will ultimately guide novel treatment approaches aimed at intervening on early biological changes before they translate into behaviors and psychopathology.

PI_NAMEs: MELHEM, NADINE M.;PERLMAN, SUSAN B (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Adolescence;Adult;Affect;Age;aged;Amygdaloid structure;Animals;Area;Behavior;Behavioral;Biological;biological adaptation to stress;biological systems;Brain;Caregivers;caregiving;Cessation of life;Child;Chronic;Chronic stress;comparison control;Conflict (Psychology);Development;Divorce;Down-Regulation;early childhood;early life stress;Emotional;Environment;Exposure to;Family;Family Process;Foundations;Frequencies;Hair;Hippocampus;Human;Hydrocortisone;Hyperactivity;hypothalamic-pituitary-adrenal axis;improved;Institutionalization;Intake;Intervention;Magnetic Resonance Imaging;Measures;Mediating;Mental disorders;Mental Health;middle childhood;Modeling;neural;neural circuit;Neurobiology;neurodevelopment;Neuronal Plasticity;novel;Outcome;Parent-Child Relations;Parents;Pathway interactions;Patient Self-Report;peer;Peripheral;Population;Prevention;psychiatric symptom;Psychological Stress;Psychopathology;Race;Recording of previous events;recruit;Reporting;Research;response;Risk;Role;Salivary;sex;Signal Transduction;Socioeconomic Status;Stress;Stressful Event;stressor;Symptoms;System;teacher;Temperament;Time;Translating

PROJECT_TITLE: Biological Substrates of Maladaptive Stress Response in Early Childhood


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal is aimed at studying how neural circuits acquire and store prospective and retrospective associations between reward predictors and rewards. Since maladaptive learning and memory are common in many mental illnesses, the mechanisms learned here could improve our understanding of the specific nature of these deficits.

PI_NAMEs: K NAMBOODIRI, VIJAY MOHAN  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Animals;Behavior;Behavior Control;Behavioral;Brain;Calcium;Cues;Data;Evolution;excitatory neuron;expectation;experimental study;Extinction;fitness;Image;improved;in vivo calcium imaging;Individual;Learning;learning strategy;Medial;Mediating;member;Memory;memory acquisition;memory encoding;Memory impairment;Mental disorders;Mus;Nature;neural circuit;neuronal circuitry;Neurons;novel;Nucleus Accumbens;optogenetics;Outcome;Output;Pathway interactions;Population;Probability;prospective;prospective memory;Recording of previous events;recruit;response;Rewards;sound;Structure;Testing;Theoretical model;Therapeutic;Training;two-photon;Ventral Tegmental Area

PROJECT_TITLE: Prospective and retrospective learning in orbitofrontal cortex

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: ANTONETTI, DAVID  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Anatomy;Animal Housing;Animal Model;Animals;Anterior;Binding;Blindness;Choroidal Neovascularization;Collaborations;Computer software;Dark Adaptation;Darkness;design;efficacy evaluation;Electrophysiology (science);Electroretinography;Environment;Equipment;experience;Eye;Eye diseases;fluorescence imaging;Fostering;Funding;Gene Modified;germ free condition;Housing;Human Resources;Image;Imaging Device;imaging system;in vivo;Individual;innovation;instrument;Investigation;Laboratories;Laboratory Research;Lasers;Light;Longitudinal Studies;Maintenance;Measurement;Measures;Meridians;Michigan;Morphology;novel;novel therapeutics;Optical Coherence Tomography;Phenotype;Pilot Projects;pressure;prevent;Procedures;Research;Research Personnel;response;Retina;retinal imaging;Rodent;Rodent Model;Schedule;Scientist;slit lamp imaging;square foot;Structure;System;Testing;Therapeutic Intervention;tool;Training;Universities;Vision;Vision research;Visual;Visual System

PROJECT_TITLE: Functional Assessment Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ABCOUWER, STEVEN F (contact)

PROJECT_TERMS: Back;Cell Culture Techniques;Cell Reprogramming;Cells;Cellular biology;Centrifugation;cost effective;Dedications;Disease;DNA;DNA purification;Drops;Emergency Situation;Ensure;Equipment;equipment training;experimental study;Floor;Flow Cytometry;Funding;Genes;genome editing;Health;Human;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;innovation;Instruction;instrument;instrumentation;interest;Laboratories;laboratory equipment;Maintenance;Michigan;Modeling;Modernization;Molecular;Molecular Biology;nano;Neurons;Organoids;protein purification;Reader;Regenerative Medicine;Regenerative research;replacement tissue;Research;Research Personnel;Resources;Retina;RNA;RNA purification;Sampling;Scientist;Spectrophotometry;square foot;stem cells;Surveys;System;Temperature;Time;Tissues;Training;Transgenic Animals;Ultracentrifugation;Universities;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Molecular Biology Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HITCHCOCK, PETER F (contact)

PROJECT_TERMS: Anatomy;Cellular biology;Computer software;Computer Workstations;Confocal Microscopy;cryostat;Dedications;DNA;Electron Microscopy;Ensure;Environment;Equipment;Funding;Human Resources;Image;Image Analysis;image processing;imaging software;Imaging Techniques;Immunohistochemistry;In Situ Hybridization;instrumentation;Lasers;light microscopy;light transmission;Maintenance;Methods;Michigan;Microdissection;Microscope;microscopic imaging;Microtome - medical device;Morphology;Ophthalmology;Paraffin;Persons;Pilot Projects;preservation;Process;programs;Proteins;Protocols documentation;Research;Research Activity;Research Personnel;RNA;Running;Services;square foot;System;Technical Expertise;Tissue Fixation;tissue fixing;Tissues;tool;Training;Transmission Electron Microscopy;Universities;Vision research

PROJECT_TITLE: Morphology and Imaging Core


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Among those who initiate use of alcohol and other substances in early- to mid-adolescence, lifetime rates of alcohol and drug use disorders are 1.3 to 3 times the national average. Concurrently, adolescence is also a critical period for the development of executive control and the brain networks supporting it; a protracted process with a large window of susceptibility to influences by the environment surrounding the teen. Given the importance of executive control systems to successfully avoid high risk-seeking and uncontrolled substance use, it is crucial to understand how the neural trajectory of executive control and environmental disparities play a role in the observed individual differences in substance use initiation and escalation among adolescents.

PI_NAMEs: KARDAN, OMID  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 16 year old;Adolescence;Adolescent;adolescent substance use;Adult;Air Pollution;alcohol use disorder;alcohol use initiation;Architecture;Attention;Attenuated;Behavior;behavioral outcome;biobehavior;Brain;brain based;Brain Diseases;career;Childhood;Cognitive;cognitive development;critical period;Data;Data Set;Development;disorder prevention;disorder risk;Drug Use Disorder;Early Intervention;early onset substance use;Ensure;Environment;environmental disparity;Environmental Risk Factor;Epidemiology;executive function;Exposure to;Family;Future;Genetic;Goals;Green space;Growth;high risk;Individual;Individual Differences;Intercept;interest;Joints;Knowledge;large datasets;lens;Light;longitudinal analysis;longitudinal dataset;Longitudinal Studies;Low income;machine learning method;Measures;Mediating;Mediation;meetings;Mentorship;Methods;Michigan;Modeling;Multivariate Analysis;Neighborhoods;neural;Neurocognitive;neurodevelopment;neurogenetics;Neurosciences;novel;Outcome;Participant;peer;Phenotype;Physical environment;predictive modeling;Predisposition;preventive intervention;Process;Psychology;Public Health;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Sampling Studies;socioeconomics;Statistical Methods;substance use;Substance Use Disorder;support network;System;Teenagers;Testing;Training;Twin Multiple Birth;Vision Disorders;Visual;Work;Youth

PROJECT_TITLE: Environmental Influences on Neurocognitive Development of Control and Adolescent Substance Use

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview- based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: CORLETT, PHILIP  (contact);WOODS, SCOTT W

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Characteristics;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;comparison group;computerized;Computing Methodologies;design;Detection;Diagnosis;Dimensions;disability;disorder risk;Early Diagnosis;Early Intervention;Etiology;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;metropolitan;Modeling;neural;Neurobiology;new therapeutic target;next generation;novel strategies;online delivery;Onset of illness;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Process;Psychopathology;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Public Health;Recording of previous events;recruit;Research;Research Personnel;Risk;Risk Assessment;Role;Sample Size;screening;Secondary Prevention;Sensitivity and Specificity;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;tool;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: 5/5 CAPER: Computerized Assessment of Psychosis Risk


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative A-to-I RNA editing is a very prevalent type of RNA modification in human cells. An increasing number of A-to-I editing sites is being identified in various organisms, but mostly having unknown functional roles or regulatory mechanisms. The proposed research aims to develop and apply bioinformatic and experimental approaches to study the function and regulation of RNA editing in human brain, providing a basis for future studies on how RNA editing may contribute to human diseases.

PI_NAMEs: XIAO, XINSHU GRACE (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: 3' Untranslated Regions;Address;Adenosine;Affect;Alzheimer's Disease;Amino Acid Sequence;Amyotrophic Lateral Sclerosis;Animals;Area;ASD patient;autism spectrum disorder;Autopsy;Bioinformatics;Biological Assay;biological systems;Brain;cell type;Cells;Code;Cognition;Collection;comparison control;Data;Data Set;Development;Disease;Double-Stranded RNA;dsRNA adenosine deaminase;Embryo;Enzymes;Evolution;experimental study;Future;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genomics;Health;high throughput screening;Human;Human Biology;human disease;Individual;Inosine;insight;Introns;Life;Malignant Neoplasms;Mammals;Membrane;Mental Depression;Messenger RNA;Methodology;Methods;Modification;Molecular;Nervous System;Neurobiology;Neurodevelopmental Disorder;Neurologic Dysfunctions;neuropsychiatric disorder;neurotransmission;novel;Nucleotides;Organism;Pattern;Phenotype;Post-Transcriptional Regulation;Primates;Protein Family;Proteins;Publishing;Regulation;Reporter;Reporting;Research;RNA;RNA analysis;RNA Editing;RNA Processing;RNA Sequences;RNA-Binding Proteins;Role;Sampling;Schizophrenia;Series;Signal Transduction;Site;success;Technology;Testing;Tissues;transcriptome;transcriptome sequencing;Untranslated Regions;Untranslated RNA;Variant;Work

PROJECT_TITLE: Systematic approaches to deciphering regulation and function of RNA editing in brain

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative We propose developing a new center at Brown University named “Climate, Health, and Aging Innovation and Research Solutions for Communities (CHAIRS-C)". The theme of this center is to study how climate-related exposures such as heat and air pollution impact the health of older adults. Working in partnership with community groups and governmental organizations, we will form transdisciplinary collaborative teams to develop evidence and actionable solutions to promote healthy aging for all.

PI_NAMEs: JUST, ALLAN C. (contact);SHIREMAN, THERESA I.

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Affect;Aging;aging population;Air Pollution;Anthropology;Area;Biology;Caring;Chronic;Climate;climate adaptation;climate change;climate impact;climate science;climate-related exposures;climate-related health;Collaborations;combat;Communities;Community Actions;community collaboration;community engaged research;community engagement;Community of Practice;community partners;Compensation;Data;Data Set;Demography;design;Development;Disparity;Economics;Environment;Environmental Hazards;Equity;Event;experience;exposure pathway;Exposure to;extreme heat;extreme temperature;Faculty;Frequencies;Future;Gerontology;Goals;Government;Government Agencies;Grant;hazard;Health;Health Care Research;health data;Health Sciences;healthy aging;high risk;Housing;Human;Humidity;Income;Inequity;innovation;Institution;Interdisciplinary Study;Intervention;Learning;Local Government;Medical;medical schools;Medicine;Modeling;Names;older adult;Older Population;Outcome;Particulate;Pathway interactions;Personal Satisfaction;Pharmacoepidemiology;Planet Earth;Politics;Population;Population Sciences;Population Study;Population trends;Public Health Schools;Research;Research Personnel;Research Project Grants;Resources;response;Rhode Island;Risk;Science;social health determinants;Social isolation;Social Sciences;Societies;Sociology;State Government;Subgroup;Training;Transportation;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: CHAIRS-C: Climate, Health, and Aging Innovation and Research Solutions for Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SHIREMAN, THERESA I. (contact)

PROJECT_TERMS: Acceleration;Aging;Air Pollution;Annual Reports;Applications Grants;Chronic;Climate;climate change;climate science;climate-related health;Cognitive;Collaborations;Communities;community collaboration;community engagement;community partners;comorbidity;Creativeness;Data;data infrastructure;design;Development;diversity and inclusion;Education;Ensure;Environment;Environmental Hazards;Evaluation;Event;evidence base;extreme temperature;extreme weather;Fostering;Foundations;Frequencies;Funding;Future;Gerontology;global environment;Goals;Government;Government Agencies;Grant;Health;Health Care Research;healthy aging;Human;Humidity;improved;Infrastructure;innovation;Interdisciplinary Study;interest;Knowledge;Laboratories;Leadership;lens;Link;Location;Medical;Mentors;Methods;Modeling;National Institute on Aging;next generation;older adult;Outcome;Particulate;Pharmaceutical Preparations;Policies;Policy Maker;Pollution;Population;population health;pressure;Productivity;Public Health Schools;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Risk;Role;Science;Societies;success;Translating;Universities;Vulnerable Populations


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: JUST, ALLAN C. (contact)

PROJECT_TERMS: Acceleration;Address;Adverse effects;Adverse event;Aging;Air Pollution;Alzheimer's disease related dementia;anthropogenesis;Anti-Cholinergics;Back;Big Data;Biometry;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic;Climate;climate change;climate-related exposures;climate-related health;Communities;community engagement;community partners;comparative;Complex;Crossover Design;dashboard;Data;Data Set;design;Diabetes Mellitus;Emergency department visit;End stage renal failure;Environmental Epidemiology;Epidemiologist;Epidemiology;epidemiology study;Event;extreme heat;extreme temperature;fine particles;Frequencies;greenhouse gases;Health;health disparity;Health Services Research;health warning;healthy aging;Hospitalization;hospitalization rates;Human;Humidity;improved;indexing;Individual;Infrastructure;innovation;Interdisciplinary Study;Lead;Link;Literature;Machine Learning;Medicaid;Medicare;Modeling;Modification;mortality;multidisciplinary;older adult;Particulate;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;Physiologic Thermoregulation;Policies;Policy Maker;Population;Predisposition;primary outcome;Public Health;public health intervention;public health priorities;Recommendation;Records;remote sensing;Research;Research Project Grants;Resources;Rhode Island;Risk;Science;secondary analysis;social determinants;social health determinants;spatiotemporal;Stratification;System;Technology;Temperature;tool;United States;United States National Aeronautics and Space Administration;Work


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: GADBOIS, EMILY AURORA (contact)

PROJECT_TERMS: Acute;Advocate;Aging;Air;Area;Awareness;Caregivers;Chronic;Climate;climate change;climate impact;climate science;climate-related health;Collaborations;collaborative approach;Communication;Communities;community engagement;community partners;empowerment;Ensure;Environmental Health;environmental justice;Equity;Fostering;General Population;Goals;Government Agencies;Health;Health protection;healthy aging;innovation;Justice;meetings;member;multimodality;older adult;Ownership;Pharmaceutical Preparations;Policy Maker;Prevalence;Process;Productivity;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Rhode Island;Risk;Service provision;Services;Social isolation;System;Translating;Translations;Universities;Work;World Health Organization


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Social Determinants of Health

PI_NAMEs: FUSSELL, ELIZABETH  (contact)

PROJECT_TERMS: Academic Training;Acceleration;Address;Adoption;Advisory Committees;Advocate;Aging;Anthropology;Area;Articulation;Attention;Award;Biology;career;Chronic;Climate;climate change;climate data;climate impact;climate-related exposures;climate-related health;Collaborations;Communication;Communities;community engaged research;community engagement;community partners;Data;design;Development;Discipline;Economics;Education;Educational Curriculum;Educational workshop;Emergency Situation;Enrollment;Ensure;Environment;Equity;expectation;exposure pathway;Faculty;Fostering;Future;Gerontology;Health;Health Care Research;Health Hazards;health inequalities;healthy aging;Human;innovation;Institution;institutional capacity;Institutionalization;interdisciplinary collaboration;Intervention;Investments;Knowledge;Lead;Manuscripts;medical schools;Medicine;member;Mentors;Methods;Modeling;next generation;older adult;Output;Phase;Pilot Projects;Planet Earth;policy recommendation;Politics;Population;Population Study;Postdoctoral Fellow;Process;programs;Public Health;Public Health Schools;Publishing;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;Risk;Science;skills;Social Sciences;Societies;Sociology;Students;Sustainable Development;symposium;Training;undergraduate student;United States National Institutes of Health;Universities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Heart failure is an incurable, progressive disease that impacts approximately six million Americans and has a five-year mortality of fifty percent, with a disproportionate burden among underserved populations. For patients with heart failure with reduced ejection fraction, evidence-based, guideline-endorsed prescription therapies improve quality of life and reduce mortality but are often not prescribed. Bringing together key stakeholders, this project aims to design the components of a multilevel implementation intervention to equitably increase the prescription of evidence-based, guideline-recommended medical therapies for patients admitted to the hospital with heart failure with reduced ejection fraction.

PI_NAMEs: CASCINO, THOMAS MATTHEW (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute;Address;Admission activity;Affect;Ambulatory Care Facilities;American;Applications Grants;Award;Cardiovascular system;career;career development;Caregivers;Caring;Case Series;Catalogs;Chicago;Chronic Disease;Clinical;clinical care;Communities;Complex;cost;Data;Data Analyses;Data Analytics;data integration;Decision Making;design;Development;Development Plans;Disparity;Dose;EFRAC;Electronic Health Record;Equity;ethnic minority;Ethnic Origin;evidence base;experience;Female;Funding;Future;Goals;Grant;Guidelines;Health;Health Care Research;health equity;health equity promotion;Health system;Heart failure;heart failure with reduced ejection fraction;Hospitalization;Hospitals;implementation determinants;implementation evaluation;implementation intervention;implementation science;implementation trial;improved;improved outcome;Inpatients;Inservice Training;Institution;instructor;Intervention;Interview;Life;Life Expectancy;low socioeconomic status;Manuscripts;Maps;Medical;medical schools;Medicine;Mentored Clinical Scientist Development Program;Mentorship;Methodology;Methods;Michigan;Modeling;Monitor;mortality;multi-site trial;multidisciplinary;National Heart, Lung, and Blood Institute;outcome disparities;Paper;Patient Admission;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Persons;Pharmaceutical Preparations;Physicians;Population;Process;Progressive Disease;Provider;provider behavior;Publishing;Quality of life;Race;racial minority;Recommendation;Research;Scientist;sex;Site;skills;Socioeconomic Status;Strategic vision;therapy design;Training;Training Activity;treatment optimization;Underserved Population;United States National Institutes of Health;Universities;uptake;Variant;Work;Writing

PROJECT_TITLE: Development of a multilevel implementation intervention to equitably prescribe evidence-based therapy for hospitalized heart failure patients

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Veterans Health Administration (VA) will join a network of other genomics-enabled learning health systems to conduct network-wide implementation projects promoting the uptake of evidence-based genomic medicine interventions. Projects will include pharmacogenomic testing to optimize pharmacotherapy, germline testing to inform cancer treatment, use of electronic medical records to identify patients with undiagnosed genetic diseases, or others selected by the network. These projects will determine the best strategies for implementing genomic medicine across the nation’s health systems, including in medically underserved areas.

PI_NAMEs: ORLANDO, LORI ANN;SCHEUNER, MAREN THERESA;VASSY, JASON L (contact);VOORA, DEEPAK

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Acceleration;Adoption;All of Us Research Program;cancer care;cancer therapy;Caring;Characteristics;Clinical;clinical decision support;Clinical Oncology;Clinical Pathways;clinical research site;Communities;comorbidity;Computerized Medical Record;Consult;Country;Data;data ecosystem;deep learning;Diagnosis;Dissemination and Implementation;Electronic Health Record;Equity;Ethnic Population;evidence base;Evidence based practice;Family;Feedback;Genetic;Genetic Diseases;Genetic Services;genetic testing;Genome;Genomic medicine;Genomics;Geographic Locations;Germ Lines;Guidelines;Health;health professional shortage areas;Health Services Research;Health system;Health Technology;Healthcare;Healthcare Systems;implementation science;implementation strategy;implementation trial;improved;informatics infrastructure;Infrastructure;innovation;Intervention;Learning;Mainstreaming;Malignant Neoplasms;Measurement;Medical Genetics;Medically Underserved Area;Mendelian disorder;Mental Health;military veteran;Mission;Modeling;Molecular;multidisciplinary;multimodality;oncology program;Outcome;Patient Care;patient oriented;patient population;Patient-Focused Outcomes;Patients;Performance;Persons;Pharmacogenomics;Pharmacotherapy;physical conditioning;Policies;Population;precision oncology;Primary Care;Private Sector;programs;racial population;real time monitoring;recruit;Reporting;Research;Resources;routine care;Scientist;Sequential Multiple Assignment Randomized Trial;Services;Standardization;Structure;telegenetics;telehealth;Testing;Translational Research;trial design;tumor;Underserved Population;United States Department of Veterans Affairs;United States Health Resources and Services Administration;uptake;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: The VA Genomics Learning Health System: Implementing genomic medicine across diverse veteran communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview-based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: ELLMAN, LAUREN M (contact)

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;computerized;Computing Methodologies;design;Detection;Deterioration;Diagnosis;Dimensions;Early Diagnosis;Early identification;Early Intervention;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;Modeling;neural;Neurobiology;new therapeutic target;next generation;online delivery;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Psychopathology;Psychoses;psychosis risk;psychotic symptoms;Public Health;Publishing;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Sample Size;screening;Secondary Prevention;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: CAPER: Computerized Assessment of Psychosis Risk


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Title: Use of NLP to extract risk Indicators for Immunologic disease from the Text of EHRs. (UNIITE) Narrative: Primary immunodeficiency diseases/Inborn Errors of Immunity (PIDs/IEIs) cause significant morbidity and mortality, yet they are under-recognized leading to suboptimal patient outcomes. Biomedical informatics approaches coupled to electronic health record functionality can improve early detection and annotation of PID patient features. In particular, text mining offers tremendous opportunities to detect, track, and drive novel insights for PID/IEI patients and for advancing understanding about human immunology.

PI_NAMEs: RIDER, NICHOLAS L (contact);ROBERTS, KIRK EDWARD

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Achievement;Adoption;advanced disease;Algorithms;analytical method;analytical tool;Automobile Driving;Awareness;Biological;biomedical informatics;Categories;Cessation of life;Child health care;Classification;Clinical;Clinical Immunology;clinical practice;clinically relevant;Code;cohort;Collection;comparison control;congenital immunodeficiency;Coupled;Data;Data Element;data mining;Data Set;Defect;Detection;Diagnosis;Diagnostic;digital health;disability;Disease;Early Diagnosis;Economics;Electronic Health Record;electronic structure;Elements;follow-up;Foundations;Future;Goals;Health;health information technology;Health Personnel;health record;Healthcare Systems;Hospitalization;Human;Immune;Immune System Diseases;Immunologics;Immunology;Impairment;improved;Individual;Infection;innovation;insight;International;interoperability;Knowledge;Laboratories;Language;large datasets;Learning;machine learning framework;machine learning model;Manuals;Methodology;Methods;Mining;Modeling;Molecular;Morbidity - disease rate;mortality;Natural Language Processing;Natural Language Processing pipeline;neural;novel;Ontology;Organ;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Positioning Attribute;prevent;Process;Rare Diseases;Risk;Risk Assessment;scale up;Societies;Statistical Models;Structure;structured data;supervised learning;Supervision;System;Techniques;Testing;Text;text searching;Time;tool;unstructured data;Work

PROJECT_TITLE: Use of NLP to Extract Risk Indicators for Immunologic Disease from the Text of EHRs (UNIITE)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect PROJECT NARRATIVE The likelihood of developing Alcohol Use Disorder (AUD) is the greatest for those who initiate heavy drinking in their early teens. Identifying biomarkers associated with possible precursors and effects of early drinking onset on the adolescent brain development could point to potential causes and deficits of AUD, which could in turn improve preventative care in clinical, parenting, and educational settings.

PI_NAMEs: ZHAO, QINGYU  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;Adolescence;Adolescent;adolescent brain development;Adult;Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;alcohol use initiation;alcohol-related injury;Alcohols;Behavioral;Biological Markers;biomarker identification;Brain;Brain Diseases;Brain region;Cause of Death;Child Rearing;Clinical;cohort;Collection;Complex;Data;Dependence;Development;deviant;Diagnosis;Diffusion Magnetic Resonance Imaging;Distal;drinking;drinking onset;early drinking;Education;Ethnic Origin;experience;Functional Magnetic Resonance Imaging;Future;Gender;Heavy Drinking;Heterogeneity;Image;Impaired cognition;improved;Injury;insight;Link;longitudinal analysis;longitudinal, prospective study;Measurement;Modeling;multimodal neuroimaging;neurodevelopment;Neurons;Neuropsychology;Participant;Persons;Phenotype;Prevention;Preventive care;Puberty;Recording of previous events;repaired;Research Personnel;resilience;Scanning;sex;Structure;Teenagers;Testing;tool;Training;underage drinking;United States;Variant;Visit;white matter;Youth

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: San Diego

ORG_NAME: DARE BIOSCIENCE, INC.

PHR: Infants that are born prematurely, before 37 weeks of pregnancy, are likely to have more health problems than those carried to term, including serious problems that affect the brain, lungs, vision, and hearing. Progesterone is a natural hormone that is involved in maintaining healthy pregnancies, and progesterone supplementation is the gold standard of treatment for women who are at high risk for premature birth. This project aims to develop an intravaginal ring device to supply bioidentical progesterone to the cervix and vaginal epithelia of at-risk women, to prevent preterm birth and improve neonatal outcomes.

PI_NAMEs: FRIEND, DAVID R (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Advanced Development;Affect;American College of Obstetricians and Gynecologists;Biological Sciences;Brain;capsule;Centers for Disease Control and Prevention (U.S.);Cervix Uteri;Child;Clinic Visits;Clinical Research;clinical risk;Collaborations;comparative;cost;Country;Data;Devices;Disease;Dose;Drug Kinetics;Economic Burden;Ensure;Epithelium;Face;Female;first-in-human;Friends;Gel;Genes;Health;healthy pregnancy;Hearing;high risk;High Risk Woman;Hormones;improved;In Vitro;in vivo;Infant Mortality;Infection;Inflammation;Intramuscular Injections;Laboratories;Length of Stay;liquid chromatography mass spectrometry;Lung;manufacture;Maternal-fetal medicine;Measures;Medical Care Costs;meetings;Methods;Necrotizing Enterocolitis;neonatal outcome;novel;off-label use;open label;Oregon;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase III trial;Postmenopause;pre-clinical;preclinical study;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;Premature Infant;prevent;Prevention;primary endpoint;Production;Progesterone;Property;Quality Control;Recommendation;Reporting;respiratory distress syndrome;Risk;Risk Factors;Risk Reduction;Safety;Science;Second Pregnancy Trimester;Self Administration;skills;social;Societies;Specific qualifier value;stability testing;Supplementation;Survivors;System;Technology;Testing;United States;United States National Institutes of Health;Universities;Vagina;Vaginal Gel;Vaginal Ring;Vision;Woman;women's diagnosis;women's treatment;World Health Organization

PROJECT_TITLE: A novel intravaginal ring technology featuring the sustained release of natural progesterone for the prevention of preterm birth in at-risk women


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORTH DARTMOUTH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS DARTMOUTH

PHR: PROJECT NARRATIVE The “brain-eating amoeba” Naegleria fowleri can migrate through narrow channels in the skull and within brain tissue, causing a rare but often-fatal form of encephalitis. While cell migration has been described in extensive detail in animal cells, Naegleria diverged from this lineage over a billion years ago—before plant and animal lineages diverged—and it is therefore unknown whether mechanisms underlying animal cell motility are conserved in Naegleria. The goals of this application are to define the molecular basis of Naegleria’s cell migration in environments that mimic the brain, thereby providing a foundation to understand how Naegleria and similar pathogens cause disease.

PI_NAMEs: VELLE, KATRINA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Defining cytoskeletal mechanisms driving cell motility in Naegleria

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) are a major public health concern, costing over $321 Billion and affecting more than 6.5 million individuals in the United States alone, and these numbers will continue to grow with our aging population. The exact causes of AD/ADRD are unknown, although an important component involves dysfunction of regulatory brain cells, called inhibitory interneurons, and results in over-excitation and abnormal activity in brain circuits that serve memory and cognition. In our planned research, we aim to define the causes for inhibitory interneuron dysfunction and find ways to reverse this problem, advancing the mission of the NIH to decrease illness, reduce disability, and prolong life for AD/ADRD patients.

PI_NAMEs: CHEN, KEVIN SHOWEN (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Abeta clearance;abeta toxicity;Address;Affect;Age;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease therapy;Amyloid beta-Protein;Anatomy;Autopsy;Behavior;Bioenergetics;Biological Assay;Biology;Brain;brain cell;career development;Catalogs;Cell Therapy;Cognition;Cognitive;cognitive function;cognitive performance;Corpus Callosum;cost;Data;Dementia;Development Plans;disability;Disease;effective therapy;Electroencephalography;epileptiform;Exhibits;experience;Fimbria of hippocampus;Foundations;Functional disorder;Future;Gene Expression;Genes;Genetic Transcription;Goals;Graft Survival;Hippocampus;Human;human induced pluripotent stem cells;human model;Hyperactivity;immunocytochemistry;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;innovation;Innovative Therapy;Insulin-Like Growth Factor I;Interneurons;Knowledge;Learning;Lentivirus Vector;Life;Link;Literature;Maps;Measures;Mediator;Memory;Memory impairment;Mentors;Metabolic;metabolic phenotype;Metabolism;Methods;Mission;Mitochondria;Modeling;Morphology;morris water maze;mouse model;Nerve Degeneration;Nervous System Disorder;network dysfunction;neural circuit;neural network;Neurons;neuroprotection;Neurosciences;Neurosurgeon;neurotrophic factor;next generation;novel;novel strategies;Operative Surgical Procedures;Outcome;Output;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Performance;Physiological;Physiology;Positioning Attribute;prevent;Public Health;Regulation;Research;research and development;restoration;Scientist;sex;Signal Transduction;Stains;Stem cell transplant;Structure;Synapses;synaptogenesis;System;Testing;Therapeutic;therapeutic target;Training;transcription factor;transcriptome;transcriptomics;Translating;translational study;Transplantation;United States;United States National Institutes of Health;white matter;Work

PROJECT_TITLE: Mapping and modeling inhibitory interneurons in Alzheimer's disease and related dementias: novel strategies to reverse neural network dysfunction

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Glioblastomas rank among the most lethal of human cancers with only palliation from current therapies, suggesting that novel therapies are needed. The proposed studies will investigate how aging promotes glioblastoma growth. To translate these findings into potential cancer therapies, combinations of drugs targeting these connections will be tested against glioblastomas.

PI_NAMEs: RICH, JEREMY N (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Aging;aging brain;Apical;Brain;Brain Neoplasms;cancer stem cell;cancer therapy;cancer type;Cell division;Cells;Combined Modality Therapy;Complex;Cues;Development;Drug Combinations;Drug Targeting;Ecosystem;empowerment;Epigenetic Process;Equilibrium;Generations;Glioblastoma;Growth;Homeostasis;Human;Immune Evasion;Incidence;Inflammation;insight;Invaded;Laboratories;Maintenance;Malignant Neoplasms;Metabolic;Metabolic Pathway;metabolomics;Molecular;mortality;Natural regeneration;neoplastic cell;nerve stem cell;Nervous System;novel;novel therapeutics;Nuclear;Nutrient;Organ;Organoids;palliation;Patients;precision medicine;pro-aging;programs;Proliferating;regeneration potential;Regulation;resilience;self-renewal;Signal Transduction;stem;stem cell niche;stem cells;Testing;Therapeutic;therapeutic target;therapy resistant;tissue injury;Tissues;transcriptomics;Translating;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells;wound response

PROJECT_TITLE: Targeting Glioblastoma Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE SCN3A neurodevelopmental disorder is a devastating condition caused by mutation of the gene SCN3A (which encodes the sodium channel subunit Nav1.3) and is defined by treatment-resistant epilepsy, severe/profound intellectual disability, and malformation of cortical development, the latter being a surprising consequence of dysfunction of an ion channel. The objective of this proposal, which employs cutting-edge tools and innovative technical approaches in newly-generated advanced model systems, is to investigate the pathogenic mechanisms that underlie epilepsy and brain malformation in SCN3A neurodevelopmental disorder. The long- term objective of this research is to (1) understand the normal role of Nav1.3 in the function of developing neurons and (2) advance from preclinical models to mechanistically oriented treatments or preventative therapies in human patients.

PI_NAMEs: GOLDBERG, ETHAN M (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acceleration;Acute;Alleles;Anticonvulsants;Biological Models;biophysical properties;Biophysics;Birth;Brain;brain malformation;Calcium;Cell Line;Cells;Cerebral cortex;channel blockers;Chronic;Clinical;clinical application;clinical phenotype;cohort;Cortical Malformation;CRISPR correction;CRISPR/Cas technology;Data;Defect;Dependence;Development;Disease;Electrophysiology (science);Electroporation;Embryo;Epilepsy;Exhibits;experimental study;Functional disorder;gain of function;Gene Mutation;Genes;genetic variant;Genetic Variation;Heterozygote;Human;human disease;human induced pluripotent stem cells;Immunohistochemistry;Impairment;in utero;In Vitro;Inherited;innovation;Intellectual functioning disability;Ion Channel;Knock-in Mouse;Lead;Link;loss of function;LoxP-flanked allele;malformation in cortical development;Maps;Mediating;Membrane Potentials;migration;Modeling;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Neurites;Neurodevelopmental Disability;Neurodevelopmental Disorder;neuronal excitability;Neurons;Neurosciences;novel;novel therapeutics;overexpression;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;pharmacologic;Pharmacology;Physiology;Placenta;postnatal;Pre-Clinical Model;pregnant;prevent;Prevention;Preventive measure;Preventive therapy;Property;Prosencephalon;pup;Registries;Research;Resistance;Role;severe intellectual disability;Severities;Severity of illness;Slice;Sodium;Sodium Channel;System;targeted treatment;Testing;Time;tool;Translating;Variant;variant of unknown significance;voltage;voltage clamp

PROJECT_TITLE: Pathomechanisms of SCN3A-related neurodevelopmental disorder

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Substance use disorder (SUD) is characterize by recurrent drug-taking behavior that often resembles the renewal-induced relapse as the subjects are re-exposed to the original drug context, after a successful extinction-based treatment. Unfortunately, conventional extinction therapy and its adjunct medications have shown limited success in the clinic, perhaps due to a lack of understanding of the molecular mechanisms governing the transfer of the learned extinction memories from clinical to drug-associated contexts. Thus, my training plan is focused on understanding the impact of extinction-based therapy on reprogramming drug-associated memories, phenotypes and genome-wide transcriptional codes following extinction success, renewal-induced relapse, withdrawal and decision-making processes in a rodent model of cocaine self-administration.

PI_NAMEs: MARTINEZ-RIVERA, FREDDYSON J (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;adverse outcome;Attenuated;Award;Behavior;Behavior Therapy;Behavioral;Brain;Brain region;cell type;Cells;Clinic;Clinical;clinically relevant;cocaine seeking;cocaine self-administration;Code;Conflict (Psychology);cost;Cues;Data Set;Decision Making;design;Dopamine;drug seeking behavior;Drug usage;Enterobacteria phage P1 Cre recombinase;Event;Exposure to;Extinction;Faculty;Failure;Gene Transfer;Genes;Genetic Transcription;genome-wide;Hippocampus;Home;Individual;Individual Differences;knock-down;Learning;learning extinction;Life;Link;long term abstinence;Mediating;Memory;Mentored Research Scientist Development Award;Mentors;Modeling;Molecular;neural;neurobehavioral;Neurobiology;Neuronal Plasticity;Neurons;novel;Nucleus Accumbens;Outcome;paired stimuli;Persons;Pharmaceutical Preparations;Phenotype;Positioning Attribute;pre-clinical;prevent;Procedures;Process;programs;Punishment;Rat Transgene;Rattus;Recurrence;Relapse;relapse prevention;Research;Resistance;response;Rewards;Rodent Model;Self Administration;Self-control as a personality trait;Shock;Signal Transduction;Substance Use Disorder;success;Testing;Training;transcription factor;transcriptional reprogramming;transcriptome;transcriptome sequencing;transcriptomics;translational model;Viral;Viral Vector;Withdrawal

PROJECT_TITLE: Transcriptional reprogramming of drug-associated memories in the nucleus accumbens


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because lysine deacetylases are targets of drugs approved for treatment of several human pathologies and are under investigation for use against additional diseases. A more thorough understanding of basic lysine deacetylase functions in regulation of transcription will promote efficient clinical use of these approved therapeutics and the development of more targeted inhibitors for regulating the epigenome in disease treatment.

PI_NAMEs: SMITH, CATHARINE LYNN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Biochemical;Biological Assay;Biological Models;cancer therapy;Cell Physiology;Cells;ChIP-seq;Chromatin;Circadian Rhythms;Clinical;Collaborations;Complex;Coupled;course development;Data;Deacetylase;Development;Disease;Doctor of Philosophy;Drug Targeting;Enhancers;Ensure;Epigenetic Process;epigenome;experience;Fluorescent in Situ Hybridization;Formulation;Frequencies;gene repression;Genes;genetic corepressor;Genetic Transcription;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Goals;Histone Deacetylase;Histone H3;Human Pathology;immune function;Immunoprecipitation;Impairment;inhibitor;innovation;Investigation;Kinetics;Knowledge;Life;Ligands;live cell imaging;Lysine;Maintenance;Measures;Mediating;Metabolism;Methods;Modeling;Molecular;Nervous System Disorder;next generation sequencing;novel;NuRD complex;Patients;Pharmaceutical Preparations;Physiological Processes;prevent;promoter;Proteins;Public Health;Publishing;recruit;Regulator Genes;Regulatory Element;Research;Resources;RNA Polymerase II;Role;Signal Induction;Signal Transduction;single molecule;Site;Small Interfering RNA;Steroid Receptors;Steroids;Study models;Testing;Therapeutic;Therapeutic Uses;Toxic effect;Transactivation;Transcript;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcriptional Activation;Transcriptional Regulation;United States National Institutes of Health;Work

PROJECT_TITLE: The Positive Roles of Lysine Deacetylase Complexes in Regulating Transcriptional Dynamics

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Infant Mortality;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pediatric Cancer;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE While it is now possible to rapidly and efficiently characterize our genetic makeup to guide our health and healthcare, the routine use of our genetics in clinical care – what is known as “genomic medicine” – remains limited. In this project, the University of Utah (UU) and its Genomics Learning in the Utah Ecosystem (GLUE) Center will contribute to the establishment of a Genomics-Enabled Learning Health Systems Network that aims to spark the much wider implementation of genomic medicine, including for using our genetic makeup to identify what medications are likely to be most safe and effective to use; providing a chatbot-facilitated approach to enable widespread education and mail-in testing for genetic conditions that significantly increase our risk of common and potentially preventable diseases such as cancer and heart disease; and automatically identifying critically ill newborns who may benefit from genetic testing that identifies treatable causes for their life-threatening conditions. Ultimately, the UU GLUE Center aims to collaborate with like-minded peers across the nation to discover and disseminate the most effective and fair strategies for enabling genomic medicine at scale to improve health and healthcare in the United States and beyond.

PI_NAMEs: KAWAMOTO, KENSAKU  (contact);TRISTANI-FIROUZI, MARTIN ;YANDELL, MARK DOUGLAS

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Area;Artificial Intelligence;cancer genetics;cancer risk;Caring;Centers for Disease Control and Prevention (U.S.);chatbot;Clinic;Clinical;clinical care;clinical decision support;Collaborations;critically ill newborn;detector;digital health;Disease;Disparity;Ecosystem;Education;Effectiveness;Electronic Health Record;electronic health record system;empowerment;Ensure;Equity;Evaluation;Evidence based intervention;experience;Familial Hypercholesterolemia;Genetic;genetic approach;Genetic Diseases;genetic makeup;Genetic Screening;genetic testing;genome sequencing;Genomic medicine;Genomics;Guidelines;Health;health care disparity;Health system;Healthcare;Heart Diseases;Hereditary Neoplastic Syndromes;Home;Human;implementation science;improved;Informatics;Infrastructure;Institution;interoperability;Intervention;Investments;Laboratories;Leadership;Learning;learning progression;Life;Malignant Neoplasms;Medical Records;member;Mendelian disorder;Mind;Mission;Multicenter Studies;multidisciplinary;National Human Genome Research Institute;Neonatal Intensive Care Units;Newborn Infant;Ontology;open source;open source tool;Outcome;Patient Care;Patients;Pediatric Hospitals;peer;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Physician Executives;Pilot Projects;Population;population based;Pragmatic clinical trial;pragmatic trial;Provider;Public Health;Research;Resources;Risk;safety net;search engine;Site;standard of care;success;support network;Technology;Testing;Time;tool;Translational Research;United States;Universities;uptake;Utah;Vision;whole genome

PROJECT_TITLE: Empowering Interoperable Genomics-Enabled Learning Health Systems at Scale


ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Clonal hematopoiesis (CH) is the pre-cancerous and age-related expansion of hematopoietic stem cells (HSCs) often caused by acquired mutations in leukemia driver genes. While CH research has focused on risk of developing blood cancers such as acute myeloid leukemia (AML), having CH also increases the risk of inflammatory diseases. This project utilizes large genomic and clinical datasets to define CH-associated inflammatory disease outcomes, model risk of inflammatory comorbidity in CH and explore the use of hypomethylating agents as a therapeutic strategy to alleviate inflammation disease burden in CH.

PI_NAMEs: WEEKS, LACHELLE DAWN (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute Myelocytic Leukemia;adverse outcome;Advisory Committees;age related;Algorithms;Arthritis;biobank;Biology;Blood;Blood Cells;burden of illness;cancer risk;career;career development;Caring;Case/Control Studies;Cells;Chronic;Chronic Myelomonocytic Leukemia;Clinical;clinical care;Clinical Data;clinical phenotype;clinical practice;Clinical Research Protocols;Clinical Trials;cohort;Communities;comorbidity;Counseling;cytopenia;Dana-Farber Cancer Institute;Data;data repository;Data Set;Databases;Dedications;design;Development;Diagnosis;Disease;Disease Management;Disease Outcome;disease phenotype;Dose;Dysmyelopoietic Syndromes;Electronic Health Record;Environment;Excess Mortality;Exposure to;Funding;Future;Genes;Genetic;genetic epidemiology;genomic data;Genomics;Genotype;Goals;Gout;Hematologic Neoplasms;Hematologist;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic stem cells;Immune;Immune signaling;Immunologic Memory;improved;Individual;Inflammation;Inflammatory;International;Intervention;Label;Laboratories;large datasets;leukemia;Link;Malignant - descriptor;Malignant Neoplasms;Medical;Medical Oncology;Medicare;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mortality;multiple chronic conditions;Mutate;Mutation;Myeloproliferative disease;Non-Malignant;novel;Oncology;Outcome;Patient Care;Patient risk;Patients;Pattern;Penetrance;Phenotype;Physicians;Policies;Population;Population Sciences;predictive tools;premalignant;prevent;Prevention;Principal Investigator;Probability;Research;research and development;Rheumatism;Rheumatology;Risk;risk prediction;risk prediction model;Role;Scientist;SEER Program;Somatic Mutation;Specificity;Statistical Algorithm;Symptoms;Syndrome;System;systemic inflammatory response;Temporal Arteritis;Therapeutic;therapeutically effective;Time;Translational Research;translational scientist;tumor-immune system interactions;Work;Writing

PROJECT_TITLE: Inflammatory Disease Associations in Clonal Hematopoiesis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative Elevated mental health problems have been documented in children of divorced families – over 8.1 million in the US – and in their parents. While behavioral parent training interventions, including digital interventions, have demonstrated success to reduce children's mental health problems, they have shown weaker effects in divorced parents with elevated psychological distress, and digital fully self-administered interventions have shown no effects to reduce the distress of divorced parents. By developing digital mindfulness training components and adding them to an existing evidence-based parenting intervention, as a combined, web- based, self-administered intervention, this project has great potential to maximize its reach and impact, reducing mental health problems in high-risk divorced families.

PI_NAMEs: ZHANG, NA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Applied Research;Arizona;Behavioral;career;Child;Child Mental Health;Child Rearing;Clinical;clinical training;cognitive control;Collaborations;Connecticut;design;digital;digital intervention;Distress;Divorce;Educational Intervention;Educational workshop;Electronics;Emotions;evidence base;Evidence based practice;executive function;experience;Family;Goals;Health;high risk;Human Development;Informal Social Control;Intervention;Massachusetts;Mental Health;Mentorship;Methods;mindfulness;mindfulness intervention;Mindfulness Training;Online Systems;Paper;parenting intervention;Parents;Philosophy;Policies;prevent;Principal Investigator;programs;psychological distress;Psychologist;Research;Research Activity;Research Personnel;Risk;Science;Self Administration;skills;Socialization;success;symposium;Techniques;Testing;therapy development;Training;Training Activity;Universities;user centered design;Washington;webinar;Wisconsin;X Inactivation

PROJECT_TITLE: A digital mindfulness-informed parenting intervention for high-risk divorced families


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The anesthetic ketamine is efficacious as a fast-acting antidepressant in patients with treatment refractory major depression, but its potential for long-term antidepressant use is limited by its abuse potential and capacity to produce dissociative effects. Ketamine is rapidly metabolized to a number of biologically active metabolites that are pharmacologically distinct from ketamine, including (2R,6R)-hydroxynorketamine, which in preclinical models, shares ketamine’s therapeutic effects without its side effects. We propose to utilize preclinical models including electrophysiological characterization of brain synapse function to further determine the relevant antidepressant- and side-effect profiles of ketamine’s hydroxynorketamine metabolites, which will lead to important mechanistic insights relevant to the development of next generation fast-acting antidepressants.

PI_NAMEs: GOULD, TODD D (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: abuse liability;Acute;Adverse effects;Affinity;Anesthetics;Anhedonia;antagonist;anti-depressive agents;antidepressant effect;Behavioral;Behavioral Assay;Biological;Brain;Brain-Derived Neurotrophic Factor;Calcium;Clinical;Cyclic AMP;Data;depressive symptoms;Development;Disease remission;Drug abuse;drug development;drug discovery;Drug Kinetics;Electrophysiology (science);experience;experimental study;Feeling suicidal;Fiber;Funding;Future;Glutamates;Goals;Hippocampus;Human;improved;In Vitro;in vivo;Individual;Innovative Therapy;insight;Ketamine;Knowledge;Major Depressive Disorder;Measurement;Measures;Mediating;Mental Depression;Metabolism;Moods;Mus;N-Methyl-D-Aspartate Receptors;neurochemistry;Neurons;Neuropharmacology;Neurosciences Research;next generation;norketamine;novel;novel therapeutics;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Phase;phase II trial;Photometry;Plasma;Population;Pre-Clinical Model;preclinical study;Preparation;presynaptic;Probability;Property;Publishing;Receptor Inhibition;Refractory;Research;Resistance;Role;safety study;side effect;Slice;Stereoisomer;Structure;Structure-Activity Relationship;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synthesis Chemistry;therapeutic development;Therapeutic Effect;translational neuroscience;Treatment Efficacy;Work

PROJECT_TITLE: Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This R35 application aims to harness the stimulator of interferon genes (STING) pathway and dendritic cell biology to restore and boost immune defense against cancer. We will focus on immune engineering of the molecular and cellular underpinnings of STING signaling by nanotechnology. Through our bench- to-clinic and back-to-bench approach, our goal is to identify and overcome existing biological and technological barriers impeding clinical progress, and ultimately apply these insights to establish a successful STING-targeted therapy in cancer patients unresponsive to current treatments.

PI_NAMEs: GAO, JINMING  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Adenosine Monophosphate;Agonist;Antitumor Response;Area;Back;bench to bedside;Binding;Biological;cancer cell;Cancer Patient;Cellular biology;Clinical;Cryoelectron Microscopy;Cyclic GMP;Defense Mechanisms;defense response;Dendritic Cells;design;DNA;early phase clinical trial;Endoplasmic Reticulum;Engineering;Ensure;Gene Activation;Gene Targeting;gene-targeted therapy;Genes;Goals;hazard;Hematopoietic stem cells;Host Defense;Hypoxia;Immune;immune checkpoint blockade;immune resistance;Immune response;Immune system;Immunity;immunoengineering;Immunooncology;innovation;insight;Intervention;Logic;Malignant Neoplasms;Mediating;Molecular;Monitor;nanoparticle;Nanotechnology;Normal tissue morphology;Pathway interactions;Patients;preclinical study;prognostic value;programs;refractory cancer;Research;response;Role;Signal Transduction;Signaling Protein;spatiotemporal;Stimulator of Interferon Genes;synergism;Technology;Tissues;Toxic effect;Transcriptional Regulation;treatment response;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Precision Engineering of STING-DC Immunity to Overcome Tumor Immune Evasion


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: It is imperative to develop effective serious illness care approaches to support children with cancer and their parents. By providing video education tools to better inform parents making decisions about life-prolonging interventions, there is an opportunity to improve their children’s quality of life throughout the care trajectory.

PI_NAMEs: VOLANDES, ANGELO  (contact);WOLFE, JOANNE

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;Advanced Malignant Neoplasm;Affect;African American;aged;Alabama;cancer care;Cardiopulmonary Resuscitation;care preference;Caring;Cause of Death;Child;Child health care;Child Support;Clinic;Clinical;Clinical Trials;Collaborations;Communication;comparison control;Computer Assisted;Dana-Farber Cancer Institute;Decision Aid;Decision Making;design;Dimensions;Disparity;Distress;Documentation;Education;end of life;Engineering;Enrollment;Ensure;Ethics;evidence base;Face;Family;Family Leave;forgetting;Goals;Healthcare Systems;Hispanic;hispanic community;Home;Hospitals;implementation science;improved;Infrastructure;innovation;Intervention;intervention effect;Language;Life;literacy;Malignant Childhood Neoplasm;Malignant Neoplasms;marginalized population;Medical;Medicine;Methods;Natural Language Processing;Not Hispanic or Latino;novel;Outcome;Parents;Patients;Pediatrics;Persons;Phase;pilot test;pragmatic randomized trial;pragmatic trial;preference;primary outcome;Process;programs;provider communication;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Respirators;Rural;Rural Community;rural patients;Site;Spanish/English;telehealth;theories;therapy development;tool;Training;United States National Academy of Sciences;Universities;verbal;Waiting Lists;Writing

PROJECT_TITLE: Video Inspired Discussions about Ethical Outcomes in Pediatrics (VIDEO-PEDS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE ADHD is a common and debilitating disorder that contributes to increased chance of deleterious risky behaviors that emerge or exacerbate in adolescence, leading to long-term negative outcomes such as addiction or incarceration. This supplement requests funds to complete MRI data collection for the parent grant, which consists of a comprehensive, longitudinal, multilevel (neural, behavioral, clinical) and multimodal (functional MRI, diffusion MRI) study in youth with ADHD across the transition to adolescence. By incorporating innovative brain network analytic tools and sophisticated longitudinal modeling techniques, this research will characterize developmental trajectories and identify childhood features that contribute to increased risk for negative outcomes in adolescence, leading to biomarker development for earlier detection of risk and more targeted treatment models for ADHD.

PI_NAMEs: COHEN, JESSICA R (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Academic achievement;addiction;Address;Adolescence;Adolescent;Adolescent Risk Behavior;adverse outcome;Affect;analytical method;analytical tool;Attention deficit hyperactivity disorder;Attitude;Behavior;Behavior assessment;Behavioral;behavioral impairment;Behavioral Symptoms;Biological Markers;biomarker development;Brain;Brain region;Characteristics;Child;Childhood;Clinical;Clinical assessments;cognitive control;cognitive system;cost;criminal behavior;Data;Data Collection;Decision Making;Development;developmental disease;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disparate;early detection biomarkers;Early Diagnosis;Early identification;Early Intervention;Education;Equation;Etiology;Family;Functional Magnetic Resonance Imaging;Funding;Future;Goals;graph theory;Health Care Costs;Healthcare;Hour;Hyperactivity;imaging facilities;Imprisonment;Impulsivity;inattention;Individual;Influentials;innovation;Investigation;Justice;Knowledge;Link;Literature;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Modeling;Motivation;MRI Scans;multimodality;neural;neural model;Neural Pathways;Neurobiology;neuroimaging;novel;Outcome;parent grant;Participant;Pathway interactions;Performance;preadolescence;predict clinical outcome;Predictive Value;Prevention;Process;Public Health;Regression Analysis;Research;Research Domain Criteria;response;Rest;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Taking;Savings;Schedule;Seminal;Severities;Societies;Substance abuse problem;substance use;symptomatology;Symptoms;System;targeted treatment;Task Performances;Techniques;Time;Work;Youth

PROJECT_TITLE: Longitudinal Investigation of the Neurobiological Underpinnings of Risk Behavior in ADHD throughout the Adolescent Transition: The Key Role of Cognitive Control and Motivation Network Development


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE - OVERALL  The mission of the Research and Engagement for Action on Climate and Health (REACH) Center is to bridge big data to climate solutions that advance health and environmental justice. Specifically, the Center leverages the power of novel geospatial datasets and research co-generation with governmental and non- governmental partners to research health and equity impacts of climate change mitigation and adaptation actions from local to global scales. Our ideal location in the National Capital Region, hosted at the only school of public health in Washington, DC, gives us unique opportunities to collaborate with the national-scale policy community, including the federal government and a plethora of civil society organizations engaged in climate and health policy development.

PI_NAMEs: ANENBERG, SUSAN  (contact);ORTTUNG, ROBERT WILSON;TONG, DANIEL ;VOGEL, SARAH

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acceleration;Address;Advocacy;Applied Research;atmospheric sciences;Award;base;Big Data;Capital;civil society;Climate;climate change;climate data;climate impact;climate science;climate-related health;Collaborations;Communities;community engagement;Community of Practice;community organizations;Complex;Data;Data Set;Decision Making;design;Development;Discipline;Earth science;Education;environmental justice;Equity;Estimation Techniques;Federal Government;Fellowship;Fostering;Funding;Future;Generations;Geoscience;Government;Health;health data;Human;Infrastructure;innovation;Institution;Interdisciplinary Study;interoperability;Intervention;Investigator-Initiated Research;Knowledge;Leadership;Local Government;Location;Medicine;Mission;Modeling;multidisciplinary;novel;Policies;Policy Developments;Proliferating;Public Health;Public Health Schools;Public Policy;Records;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Risk Factors;scientific atmosphere;sensor;Services;spatiotemporal;Statistical Models;statistical service;Students;Translational Research;Uncertainty;United States National Institutes of Health;Universities;Washington


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: ANENBERG, SUSAN  (contact)

PROJECT_TERMS: Address;Advisory Committees;Air Pollution;American;Area;asthma prevention;atmospheric sciences;Benchmarking;Big Data;Biometry;Capital;Climate;climate change;climate science;climate-related health;Clinical;Clinical Medicine;Collaborations;Communicable Diseases;Communication;community based participatory research;community engagement;Community Health;Community of Practice;community organizations;community partners;Coordination and Collaboration;data infrastructure;Data Set;Development;Ensure;Environmental Health;Equity;Evaluation;experience;Faculty;Funding;Funding Opportunities;Goals;Government;Grant;Health;health management;Health Policy;Health Sciences;Human;innovation;Institution;Leadership;medical schools;meetings;mid-career faculty;multidisciplinary;National Oceanic and Atmospheric Administration;novel;Occupational Health;Otolaryngology;Policies;Procedures;professor;Public Health;Research;Research Activity;Research Assistant;Research Personnel;Research Project Grants;Resources;response;scientific atmosphere;Scientist;Series;Strategic Planning;Structure;success;Surgeon;symposium;United States National Aeronautics and Space Administration;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: REACH Center Administrative Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HENNEMAN, LUCAS RICHARD FATH (contact)

PROJECT_TERMS: Accountability;Active Biological Transport;Address;Advocacy;Air;Air Pollution;Area;Asthma;Atmosphere;Big Data;Black race;Cessation of life;Cities;Climate;climate change;climate-related health;Collaborations;Communication;Communities;community partners;community-centered;Commuting;Data;Data Set;Department of Energy;design;Development;District of Columbia;Dust;Environment;environmental disparity;environmental justice;Environmental Policy;Equity;Ethnic Origin;fine particles;Future;Generations;Goals;Government;greenhouse gases;Health;health data;health equity;improved;Inequity;Intervention;Knowledge;Literature;Local Government;Modeling;Morbidity - disease rate;mortality;Motor Vehicles;Neighborhoods;Nitrogen Dioxide;novel;Outcome;Ozone;ozone exposure;Policies;Policy Developments;Policy Maker;pollutant;Population;population health;premature;Price;Race;Recording of previous events;Relative Risks;Research;Research Project Grants;Research Project Summaries;Risk;Risk Estimate;Scheme;Science;Subgroup;traffic-related air pollution;Transportation;Travel;United States;Vehicle Emissions;Washington;Work

PROJECT_TITLE: REACH Center Research Project 1


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Social Determinants of Health

PI_NAMEs: APPLEBAUM, KATIE M. (contact)

PROJECT_TERMS: Accounting;Acute;Affect;Age;Agriculture;Air;Air Conditioning;American;Area;Censuses;Cessation of life;Characteristics;Cities;climate change;climate-related health;Communities;community collaboration;community engagement;comorbidity;Data;Death Rate;design;Dialysis patients;Dialysis procedure;End stage renal failure;Epidemiology;epidemiology study;Ethnic Origin;Event;Exposure to;extreme heat;Feedback;fine particles;Fire - disasters;follow-up;Frequencies;functional status;Future;hazard;Health;Heat Waves;Hemodialysis;High Prevalence;Hour;Household;Humidity;indexing;Individual;Information Systems;interest;Kidney;Kidney Transplantation;Knowledge;Low Prevalence;metropolitan;Modeling;Monitor;mortality;patient engagement;Patient Participation;patient population;patient registry;Patients;Population;Prevalence;Prevention Measures;Prevention strategy;Preventive;Preventive measure;Publications;Race;Renal Replacement Therapy;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Project Summaries;residence;Resources;Retrospective cohort;Risk;Risk Factors;semiparametric;sex;Smoke;social vulnerability;Source;Surface;Surveys;Temperature;Time;tool;Transplantation;trend;Variant;Vulnerable Populations;Weather;Wildfire;Work

PROJECT_TITLE: REACH Center Research Project 2


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

PI_NAMEs: ORTTUNG, ROBERT WILSON (contact)

PROJECT_TERMS: Address;Affect;Award;Big Data;Climate;climate change;climate impact;climate-related health;Clinical;Clinical Research;cohort;Collaborations;Communities;community engaged research;community engagement;community partners;Data Set;design;Development;Discipline;Education;Educational Activities;Educational workshop;Ensure;Equity;experience;Fellowship;Fellowship Program;Focus Groups;Fostering;Funding;Goals;Government;Grant;Health;Health Hazards;Health protection;Human;improved;innovation;Institution;Interdisciplinary Study;interest;International;Journals;Knowledge;Lead;Leadership;Link;medical schools;Medical Societies;multidisciplinary;outreach;Persons;Phase;Planet Earth;Policies;Process;programs;Public Health;public health research;Quality of life;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Science;Series;skills;Societies;student participation;Students;System;Training;Training and Education;training opportunity;United States National Institutes of Health;Universities;Vector-transmitted infectious disease;Vision;Work;working group

PROJECT_TITLE: REACH Center Developmental Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

PI_NAMEs: VOGEL, SARAH  (contact)

PROJECT_TERMS: Acute;Air Pollutants;Air Pollution;Award;Awareness;civil society;Climate;climate change;climate policy;climate-related health;Collaborations;Communication;Communities;community engaged research;community engagement;Community of Practice;community setting;community-centered;Data;Decision Making;Deep South;design;Development;Disease;empowerment;Environmental Exposure;Environmental Health;Equity;Evaluation;experience;Exposure to;Federal Government;Fellowship;Fellowship Program;Funding;Generations;Government;Health;health inequalities;Health Policy;Healthcare Systems;Hospitals;Housing;Human;improved;Infrastructure;insight;Intervention;Investigation;Investigator-Initiated Research;Knowledge;Lawyers;Lead;Leadership;Link;Neighborhood Health Center;Output;outreach;Pilot Projects;Policies;Politics;Positioning Attribute;Process;Research;Research Activity;Research Personnel;Research Project Grants;research study;Resistance;Scientific Advances and Accomplishments;scientific literacy;Scientist;Senior Scientist;skills;Societies;Speed;State Government;Students;System;tool;Transportation;Trust;United States National Institutes of Health

PROJECT_TITLE: REACH Center Community Engagement Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TONG, DANIEL  (contact)

PROJECT_TERMS: Air;Big Data;burden of illness;Climate;climate data;climate impact;climate-related health;Code;Collaborations;Communities;community engagement;Consult;Consultations;Data;Data Set;data tools;decision research;design;Development;Disease;empowerment;Environment;environmental justice;Epidemiology;Equity;Event;experience;Exposure to;Fire - disasters;Future;Geography;Geoscience;Goals;hazard;Health;health data;health empowerment;Interdisciplinary Study;interoperability;Investigator-Initiated Research;Leadership;Literature;Maps;Modeling;Monitor;novel;Policies;Policy Analysis;remote sensing;Research;Research Personnel;Research Support;Resolution;Risk;Sampling;Scientist;screening;Series;Services;social;spatiotemporal;Statistical Data Interpretation;Techniques;Time;tool;Uncertainty

PROJECT_TITLE: REACH Center Exposure Assessment Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Climate change disproportionately affects individuals and communities experiencing social and environmental vulnerabilities and discrimination. There is a critical need for evidence-based solutions to reduce the impacts of the warming climate on marginalized communities to enable timely, effective, and impactful interventions. We propose to establish the Center for Climate: Equitable and Accessible Research-based Testing for Health (C- EARTH) to catalyze transdisciplinary research approaches involving individual- and policy-level solutions to address multiple climate risks to human health in high-risk and marginalized communities around the world.

PI_NAMEs: GOLDEN, CHRISTOPHER DEWEIR;NADEAU, KARI C. (contact);RICE, MARY B

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;Boston;Burkina Faso;Cardiovascular Diseases;career development;Cessation of life;Chronic;Climate;climate change;climate impact;climate policy;climate-related health;Collaborations;Communicable Diseases;Communication;Communities;community engagement;Community Health Aides;community partners;coral;Cost-Benefit Analysis;data infrastructure;Defect;Dependence;Development;Discipline;Discrimination;economic disparity;Emotional;Environment;Environmental Health;environmental justice;epidemiology study;Equity;Evaluation;Event;evidence base;experience;extreme heat;Food Supply;Goals;Grant;harmful algal blooms;Health;health equity;health inequalities;Heat Stress;Heat Stress Disorders;high risk;Hospitalization;Human;Impairment;implementation science;improved;Individual;International;Intervention;Justice;Lead;Leadership;Low income;Madagascar;marginalization;marginalized community;member;Mental Health;multidisciplinary;neighborhood disadvantage;Nonprofit Organizations;nutrition;Nutritional;Outcome;Persons;Physical activity;Policies;Population;population health;Population Research;Predisposition;programs;Proliferating;psychologic;Readiness;Research;Research Personnel;Research Project Grants;resilience;Resources;respiratory health;Risk;Seafood;Security;shared decision making;social;social disparities;Societies;South Africa;Subgroup;System;Temperature;Testing;Training;Translations;Trust;United States;uptake;Water Supply;Work

PROJECT_TITLE: Center for Climate: Equitable and Accessible Research-based Testing for Health (C-EARTH)


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Social Determinants of Health

PI_NAMEs: NADEAU, KARI C. (contact)

PROJECT_TERMS: Advisory Committees;Benchmarking;career development;Climate;climate change;climate impact;climate science;Collaborations;Common Data Element;Communication;Communities;community engagement;Community of Practice;cost effectiveness;Data;Data Collection;data infrastructure;data management;Databases;design;Development Plans;Ensure;Environment;Equity;Evaluation;Expenditure;Faculty;FAIR principles;Funding;Grant;Guidelines;Health;Human Resources;improved;Individual;informatics infrastructure;Infrastructure;innovation;Institution;Intervention;Maps;Monitor;neighborhood disadvantage;Nutritional;Occupational activity of managing finances;Planet Earth;Productivity;Readiness;Research;Research Infrastructure;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;Security;Structure;success;synergism;Temperature;Testing;tool;Training;Translational Research;Translations;United States National Institutes of Health;uptake

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GOLDEN, CHRISTOPHER DEWEIR (contact)

PROJECT_TERMS: 2 year old;Address;Africa;Air Pollution;Boston;built environment;Cardiopulmonary;cardiovascular health;Cessation of life;Chronic Disease;Climate;climate change;climate impact;climate-related health;cohort;Collaborations;combat;Communities;Community Developments;community engaged approach;community engagement;Community Health Aides;community organizations;community partners;community partnership;community-centered;cooling centers;coral;Data;diarrheal disease;Diet;Economics;Education;education resources;Effectiveness;Ensure;Equity;ethnic minority;Event;experience;extreme weather;Face;Family;Fishes;Food;food insecurity;Food Supply;foodborne illness;Frequencies;Goals;Government Officials;Health;health equity;Heat Stress;Heat Waves;high efficiency particulate air filter;high risk;Household;Housing;Immigrant;implementation science;improved;Individual;Institution;Intervention Studies;Link;Location;Low income;Low Income Population;Madagascar;marginalized community;marine;Measures;member;Methods;Nonprofit Organizations;nutrition;older adult;Outcome;Patients;Perception;peri-urban;Physiological;Policies;Population;preservation;prevent;promote resilience;Questionnaires;racial minority;Research;Research Project Grants;resilience;respiratory health;Rural;screening;sex;Site;Smoke;South Africa;South African;Standardization;successful intervention;Symptoms;System;Technology;Temperature;Testing;Training;Translating;uptake;Urban Community;Vulnerable Populations;Water Supply;Wildfire;Work

PROJECT_TITLE: Research Project


PI_NAMEs: BASU, GAURAB  (contact)

PROJECT_TERMS: Address;Africa;Boston;Climate;climate change;climate impact;climate-related health;Collaborations;Communication;Communities;community engagement;community organizations;community partners;community partnership;cooling centers;Data;Data Collection;Education;Educational Materials;Ensure;Equity;Evaluation;evidence base;Feedback;Fellowship Program;Financial Support;Focus Groups;Fostering;Foundations;Funding;Health;health equity;health inequalities;Heat Stress;implementation science;improved;Interdisciplinary Study;Investigation;Leadership;Learning;Madagascar;Modeling;Morbidity - disease rate;mortality;Outcome;Policies;Policy Maker;Problem Solving;Process;Relationship-Building;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Running;shared decision making;Site;social health determinants;Structure;Testing;Training;Trust;trustworthiness;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: RAMANADHAN, SHOBA  (contact)

PROJECT_TERMS: Adopted;Affect;Area;Attention;Award;Biometry;Boston;Burkina Faso;Case Study;Characteristics;Climate;climate change;climate-related health;Communities;community engaged research;community engagement;computerized data processing;cost effectiveness;Cost-Benefit Analysis;Data;Data Analyses;Data Collection;data quality;design;Development;Dissemination and Implementation;economic evaluation;effectiveness evaluation;Ensure;Environment;Environmental Health;Equity;Evaluation;Evaluation Studies;evidence base;extreme heat;Generations;Guidelines;Health;health inequalities;Heat Stress;Impact evaluation;implementation science;improved;innovation;Intervention;Intervention Studies;Knowledge;Madagascar;Measures;Modeling;Morbidity - disease rate;mortality;Outcome;outcome disparities;Policies;Policy Maker;Politics;Procedures;programs;promote resilience;Quantitative Evaluations;Research;Research Personnel;Resources;Risk;Services;Site;South Africa;Standardization;success;System;Temperature;Testing;Translations;United States National Institutes of Health;United States Public Health Service;uptake;Work

PROJECT_TITLE: Implementation Solutions, and Evaluation Core


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Nutrition;Precision Medicine;Rehabilitation;Serious Mental Illness

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will collect data on the feasibility, acceptability, efficacy, and target engagement of a personalized treatment for eating disorders. The proposed research has significant public health relevance, as it will directly lead to a highly accessible and deployable personalized treatment that can improve treatment response rates and decrease the high societal burden associated with eating disorders. The proposed research is relevant to NIH’s strategic aim 3.3b, as it will lead to the creation of a personalized treatment consistent with NIH’s precision treatment initiative.

PI_NAMEs: LEVINSON, CHERI ALICIA (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Aftercare;Anorexia Nervosa;Behavior Disorders;Binge Eating;Binge eating disorder;Body mass index;Bulimia;Caring;Cellular Phone;Cessation of life;Clinical;clinical efficacy;cognitive enhancement;Cognitive Therapy;comorbidity;Complex;Data;Death Rate;Development;Diagnosis;Diagnostic;Dropout;Eating Disorders;economic cost;evidence base;Evidence based treatment;feeding;follow-up;Fright;Goals;Heterogeneity;Impairment;improved;Individual;individualized medicine;innovation;Intervention;Investigation;Judgment;Lead;Left;long term recovery;Mental disorders;Methodology;Methods;mobile computing;Modeling;novel;Outcome;Participant;Pathology;Pathway Analysis;Pattern;personalized medicine;Population;Precision therapeutics;Prediction of Response to Therapy;prevent;Psychiatry;Psychotherapy;public health relevance;Quality of life;Randomized;Research;response;severe mental illness;smartphone based assessment;societal costs;Specific qualifier value;standard care;Structure;Symptoms;Testing;theories;therapy development;Time;Translating;treatment optimization;Treatment outcome;treatment planning;treatment response;United States National Institutes of Health;user friendly software;virtual;Visualization;Weight Gain;Work

PROJECT_TITLE: A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We previously that the neurotrophic factor BDNF in corticostriatal circuitry plays an important role in keeping alcohol drinking in moderation and that malfunction of BDNF and its receptor TrkB signaling promotes excessive and compulsive alcohol use. We recently generated data to suggest that malfunctioning of BDNF in the ventral hippocampus (vHP) promoted anxiogenesis, social anxiety and alcohol preference over social interaction. This proposal is aimed to examine the hypothesis that acutely alcohol activates BDNF/TrkB signaling in the vHP which promotes anxiolysis and social interaction whereas malfunctioning of BDNF/TrkB signaling in the vHP promotes anxiogenesis, social anxiety and alcohol preference vs. social interaction.

PI_NAMEs: RON, DORIT  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol preferring mice;alcohol use disorder;Alcohols;Alleles;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Attenuated;Axon;Behavioral Paradigm;behavioral phenotyping;Biological Models;Brain-Derived Neurotrophic Factor;cell type;Chronic;Consumption;Corpus striatum structure;Data;Dendrites;Development;drinking;Exhibits;experimental study;Female;Genes;Genetic Polymorphism;Health;Hippocampus;Human;Immunohistochemistry;Individual;Lateral;Learning;male;Medial;Mediating;Memory;Messenger RNA;Modeling;Molecular;Mus;Neurons;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;overexpression;Pathway interactions;Phenotype;Play;preference;Prefrontal Cortex;protective pathway;Proteins;response;Rodent;Role;Signal Pathway;Signal Transduction;social;social anxiety;Social Behavior;Social Interaction;Symptoms;Synapses;Synaptic plasticity;Testing;tool;transcriptomics;Translations;Up-Regulation;Viral

PROJECT_TITLE: BDNF in the ventral hippocampus and the acute and chronic actions of alcohol

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]