NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative Meiotic recombination is essential for the successful segregation of chromosomes during meiosis, the failure of which can lead to infertility, aneuploidy, genomic instability, and spontaneous abortion. Despite this essential function, recombination rate varies across genomes, populations, and species, and the forces shaping this variation remain largely unknown. This program leverages laboratory evolution and genomics in the model system Saccharomyces to interrogate the genetic and environmental components shaping recombination rate evolution, and the influence of recombination rate on genome evolution.

PI_NAMEs: SMUKOWSKI HEIL, CAITLIN SUZANNE (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Alleles;Aneuploidy;Biological Models;Cataloging;Chromosome Segregation;Environment;environmental adaptation;Environmental Monitoring;Environmental Risk Factor;Event;Evolution;Failure;fitness;Gene Conversion;Generations;Genetic;Genetic Recombination;Genetic Variation;Genome;genome sequencing;genome-wide;Genomic Instability;Genomics;Goals;Health;Individual;Infertility;Laboratories;Link;Maps;Meiosis;Meiotic Recombination;Population;programs;rate of change;recombinational repair;reproductive;Research;Saccharomyces;Shapes;Spontaneous abortion;System;Temperature;Testing;Time;Variant;whole genome;Yeasts

PROJECT_TITLE: Recombination rate variation and evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The role of the MAP kinase phosphatase-5 (MKP5) in fibrotic muscle disease will be investigated. By understanding how the pathways regulated by this enzyme are involved in the development of fibrosis in muscle will shed new insight into therapeutic avenues against the treatment of dystrophic muscle diseases.

PI_NAMEs: BENNETT, ANTON M (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;antifibrotic treatment;Architecture;Automobile Driving;Biology;cell type;Chemicals;Chronic;Collection;Complex;coronary fibrosis;cytokine;Deposition;Development;Disease;Disease Progression;Duchenne muscular dystrophy;Dystrophin;effectiveness evaluation;efficacious treatment;Enzymes;experimental study;Extracellular Matrix;extracellular signal-regulated kinase 3;FDA approved;Fibroblasts;fibrogenesis;Fibrosis;Genes;Genetic;Impairment;improved;in vivo;Inflammation;inhibitor;insight;Intervention;Knock-out;Knockout Mice;Link;MAP kinase phosphatase MKP-5;MAPK8 gene;Mediating;Mediator;Medical;Mitogen-Activated Protein Kinases;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscular Dystrophies;Mutation;Myoblasts;Myopathy;Necrosis;novel;novel therapeutics;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Predisposition;Process;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proto-Oncogene Proteins c-jun;receptor;Receptor Activation;Regulation;repaired;Role;Signal Transduction;Site;Skeletal Muscle;skeletal muscle wasting;small molecule;Specificity;structural biology;Structural Protein;Testing;Therapeutic;therapeutic target;Tissues;tool;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Wasting Syndrome

PROJECT_TITLE: Dual-specificity phosphatase action in muscle disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: BLACKSBURG

ORG_DEPT: ZOOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Zika virus (ZIKV) recently emerged and rapidly spread throughout Southeast Asia, the South Pacific, and South and Central America. In addition to the severe burden of disease and association with congenital Zika syndrome and Guillain–Barré syndrome, ZIKV’s alternative transmission routes such as sexual, perinatal, and potential blood-transfusion transmission are especially concerning. This proposal will apply a revolutionary new strategy to develop a safe, efficacious, single-dose ZIKV vaccine candidate that will be ideally suited to affordably control large outbreaks and protect the health of billions at risk of ZIKV infection.

PI_NAMEs: AUGUSTE, ALBERT J. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: adaptive immune response;Adjuvant;Affect;Americas;Arboviruses;Area;Attenuated Vaccines;biodefense;Biological;Blood Transfusion;Body Weight decreased;burden of illness;cell mediated immune response;Cells;Central America;Chimera organism;Chimeric Proteins;combat;Complementary DNA;congenital zika syndrome;Country;Data;Defect;Defective Viruses;Dengue Fever;Dengue Virus;Detection;Disease;Disease Outbreaks;dosage;Dose;E protein;efficacy evaluation;emerging virus;Ensure;env Gene Products;Equilibrium;Event;Flavivirus;Genome;Genomics;Geography;Goals;Guillain Barré Syndrome;Health protection;Human;Immune;Immune response;Immunity;Immunization;immunogenicity;In complete remission;In Vitro;in vivo;Inactivated Vaccines;Innate Immune Response;innovation;Insecta;Japanese Encephalitis Vaccines;Knowledge;Kyasanur Forest Disease;Licensing;Longevity;Macaca;Macaca mulatta;Measures;Medical;Membrane Proteins;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;novel;novel strategies;Nucleic Acid Vaccines;outbreak control;pathogen;Pathogenesis;Pathogenicity;Pattern recognition receptor;Penetration;Perinatal;prevent;prevent outbreaks;Production;protective efficacy;Regimen;Reporting;Resource-limited setting;Resources;Risk;Role;Route;Safety;safety study;Signal Transduction;South America;Southeastern Asia;success;Testing;Therapeutic;Tick-Borne Encephalitis;Translating;Translations;transmission process;Vaccinated;Vaccination;vaccine access;vaccine candidate;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine strategy;vaccine trial;vaccine-induced immunity;Vaccines;vector vaccine;Vertebral column;Viremia;Virus;Virus Replication;Virus-like particle;Yellow Fever;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: A Novel Strategy for Generating Safe and Effective Flavivirus Vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: CANNON, JUDY LIN (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Address;base;career;career development;cohort;Dedications;Environment;Evaluation;Extramural Activities;Faculty;faculty mentor;flexibility;Fostering;Funding;Generations;Goals;Health;innovation;Institution;Leadership;Mentors;Mentorship;New Mexico;next generation;Outcome;Pathway interactions;Process;Program Development;programs;Publishing;recruit;Research;Scholars Program;Science;Scientist;skills;Structure;success;Training;translational scientist;Translations;United States National Institutes of Health;Writing

PROJECT_TITLE: Institutional Career Development Core, KL2 Scholars Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative Chimeric antigen receptor (CAR) T cell immunotherapies have little effect in the treatment of solid cancers due to the tumor’s immunosuppressive microenvironment. We recently developed CAR T cells as delivery vehicles for immune modulators that neutralize immunosuppression and activate broad anti-tumor immune responses. Our strategy is effective with multiple CARs targeting different tumor types, thereby supporting its potential as a universal CAR T cell platform for solid cancer treatment.

PI_NAMEs: HUANG, YINA HSING (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adoptive Transfer;anti-tumor immune response;Antigen Receptors;Antigen Targeting;Antigens;Antitumor Response;Autoimmune Diseases;cancer immunotherapy;cancer therapy;CAR T cell therapy;CCR5 gene;Cell Survival;Cells;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;clinical translation;Colon;Colon Carcinoma;CXCR6 gene;cytokine;Cytokine Receptors;delivery vehicle;draining lymph node;Drug or chemical Tissue Distribution;Effector Cell;effector T cell;Flow Cytometry;HIF1A gene;Image;Immune;immunogenic;Immunomodulators;Immunosuppression;Immunotherapy;improved;in vivo;Infiltration;Interferon Type II;Interleukin-12;Interleukin-2;Investigation;Kinetics;Leukocytes;Liquid substance;luminescence;lung metastatic;Macrophage;Malignant Epithelial Cell;Malignant Neoplasms;MC38;Mediating;Metastatic Melanoma;Methods;MHC Class I Genes;Modeling;Molecular;mouse model;Myeloid Cells;Natural Killer Cells;Nature;neoantigens;neoplastic cell;novel;Pathway Analysis;Peptide/MHC Complex;perforin;Peripheral;Population;Race;recruit;Regulatory T-Lymphocyte;Reporting;Role;Safety;single-cell RNA sequencing;Solid;Solid Neoplasm;Spatial Distribution;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Tissues;Toxic effect;trafficking;transcriptomics;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: Activating Native Tumor Immunity with IL-33 Armored CARs

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Maladaptive processes of uncertainty have been linked to a variety of mental illnesses, including anxiety disorders, behavioral addictions, and schizophrenia. However, it is still unclear what specific computations support this ambiguous notion of uncertainty, how they go wrong, and how these same computational constructs transdiagnostically influence many mental illnesses. In this project, we address these questions in humans by collecting data from a large general population in a novel behavioral paradigm, which allows us to disentangle computations related to two major sources of uncertainty and paves the way for the development of biomarkers related to mental illnesses.

PI_NAMEs: PIRAY, PAYAM  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: adaptive learning;addiction;Address;Amygdaloid structure;Animal Behavior;Animal Experimentation;Animal Model;Animals;Anxiety;Anxiety Disorders;anxious behavior;Association Learning;Behavioral;Behavioral Paradigm;Biological Markers;biomarker development;Brain;clinically relevant;Cognitive deficits;cognitive process;Community Psychiatry;computational neuroscience;Computer Models;Data;Data Collection;Decision Making;Dependence;Diagnostic;Dissociation;experience;Failure;Functional disorder;Future;General Population;Human;Impaired cognition;Individual;Individual Differences;individual variation;instrument;Joints;Learning;Link;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;neuroimaging;Neurologic;neurophysiology;Neurosciences;Noise;novel;Organism;Outcome;Participant;Patient Self-Report;Patients;Persons;predictive modeling;Predisposition;Process;Psychiatry;Psychological reinforcement;Psychopathology;Research;Reversal Learning;Rewards;Running;Schizophrenia;Severities;Source;Symptoms;Technology;Testing;theories;trait;Uncertainty;Work

PROJECT_TITLE: Quantifying the cognitive processes supporting computations of stochasticity and volatility in humans

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Einstein-Montefiore Institute for Clinical and Translational Research’s K12 Career Development Program trains physicians and other health professionals, called Scholars, for careers in translational research. Our Scholars have a mentorship team and receive rigorous training in research methods, leadership development, communication skills, management, entrepreneurship, and team science in order to become future leaders in research that will help improve the health of the population.

PI_NAMEs: RASTOGI, DEEPA  (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Appointment;Area;Brain;career;career development;Characteristics;Clinical;Collaborations;Communication;Communities;Companions;Coupled;Data Science;Dedications;Development Plans;Discipline;Doctor of Philosophy;Educational Activities;Educational Curriculum;Entrepreneurship;ethnic diversity;Ethnic Origin;Eye;Funding;Gender;Health equity research;Health Professional;Health system;Individual;Institution;Knowledge;Leadership;leadership development;medical schools;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mission;Monitor;Nature;Nurses;Positioning Attribute;Program Development;programs;Publications;Publishing;Race;racial diversity;Research;Research Activity;Research Personnel;Science;Scientist;Series;skills;Students;success;Talents;Training;Translational Research;translational scientist

PROJECT_TITLE: CTSA K12 Program at Einstein-Montefiore


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: Aurora

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Pattern formation of the pharyngeal arch establishes the identity of cells that give rise to the bone, cartilage, and connective tissue of the face. Disruptions to this process can lead to a variety of craniofacial birth defects. The overarching goal of this project is to elucidate cell signaling pathways that establish cellular identity so that we can better understand mechanisms of development and disease.

PI_NAMEs: KANAI, STANLEY MICHINOBU (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Adult;Affect;Alleles;Anatomy;Area;Automobile Driving;Biology;bone;Branchial arch structure;career;career development;Career Mobility;Cartilage;Cell Culture Techniques;Cells;Cephalic;Chick;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Colorado;comparative;Congenital Abnormality;Connective Tissue;Core Facility;craniofacial;craniofacial development;craniofacial disorder;Data;Defect;Development;Development Plans;Disease;disease model;DNA Binding;Dominant-Negative Mutation;Dorsal;Drug Targeting;Ear;Endothelin Receptor;Endothelin-1;Ensure;Environment;Event;Face;Faculty;First Pharyngeal Arch;Future;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic;genetic approach;genome-wide;Goals;GTP-Binding Proteins;Health;Heterotrimeric GTP-Binding Proteins;Human;Immediate-Early Genes;improved;in vitro Assay;in vivo;Individual;insight;Interdisciplinary Study;Jaw;Knock-out;knockout animal;Ligands;Link;Mediating;Medical;member;Mentors;Modeling;Molecular;Molecular Analysis;Morphogenesis;multimodality;Mus;National Research Service Awards;Neural Crest Cell;novel;Occupations;Pathway interactions;Pattern;Pattern Formation;pharmacologic;pharyngeal patterning;Phenotype;Phospholipase C;Postdoctoral Fellow;Process;Productivity;programs;Proteins;Publishing;receptor;Receptor Signaling;recruit;Regulation;Regulator Genes;Regulatory Element;Reporter;Research;Research Personnel;Research Training;Resources;RNA;Role;Scanning;Shapes;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single cell sequencing;skeletal;Structure;success;Surveys;symposium;Syndrome;System;Testing;Therapeutic;Training;training opportunity;Transcription Factor AP-1;Transgenic Model;Transgenic Organisms;Translating;Universities;Variant;X-Ray Computed Tomography;XCL1 gene;Zebrafish

PROJECT_TITLE: Investigating the Role of Heterotrimeric G Proteins in Craniofacial Development and Auriculocondylar Syndrome

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: MIAMI

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Tuberculosis (TB), especially multi-drug resistant TB is a major global health problem and causes more than 1.5 million deaths annually. The worst scenario is that some multi-drug resistant TB patients have nonresponsive totally drug resistant Mycobacterium tuberculosis and cannot be treated by current multi- antibiotics regimen. This project seeks to combat this urgent public health threat by developing the hits from our recent high throughput screening campaign against bacterial DNA gyrase into new anti-TB antibiotics targeting Mtb gyrase.

PI_NAMEs: LENG, FENFEI  (contact);NEFZI, ADEL ;ROHDE, KYLE H

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: analog;Antibiotics;Antimycobacterial Agents;Antitubercular Agents;Antitubercular Antibiotics;ATP phosphohydrolase;Bacterial DNA;Binding;Biochemical;Biological;Biological Assay;cell killing;Cells;Cessation of life;Clinical;combat;Communicable Diseases;Complex;COVID-19 impact;COVID-19 pandemic;CRISPR interference;cytotoxicity;design;Detection;Development;DNA Damage;DNA Gyrase;Drug Kinetics;drug metabolism;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Enzymes;Evaluation;Fluorescence;fluoroquinolone resistance;Fluoroquinolones;Funding;Future;global health;Grant;Growth;high throughput screening;Human;improved;In Vitro;in vivo;inhibitor;Kinetics;knock-down;Libraries;Mediating;Molecular;Molecular Bank;molecular modeling;Multidrug-Resistant Tuberculosis;mutant;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Newly Diagnosed;novel;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Poison;Poisoning;preclinical study;Property;Public Health;pyridine;quinolone resistance;Reaction;Regimen;Reporting;repository;Resistance;resistance mutation;Series;side effect;small molecule libraries;Structure-Activity Relationship;success;targeted sequencing;therapeutically effective;Topoisomerase;transcriptome sequencing;Triage;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;World Health Organization

PROJECT_TITLE: Novel gyrase inhibitors targeting Mycobacterium tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-C(91)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Infectious diseases continue to extract a considerable individual, social and financial toll on humans due to factors such as the ongoing global epidemic of HIV/AIDS, increasing antimicrobial resistance rendering some pathogens untreatable, and emerging infectious diseases as reflected by the pandemic of coronavirus infection caused by SARS-CoV-2; in fact, infectious diseases represent the leading cause of morbidity and mortality worldwide. The training of new scientist-physicians who can elucidate the epidemiology, microbial pathogenesis, and host response to infectious agents is critical for the formulation of new and improved strategies to diagnose, treat and prevent infectious diseases that impact humans.

PI_NAMEs: FREDRICKS, DAVID NEAL (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Host Defense Training in Allergy and Infectious Diseases

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PD-1 is an immune inhibitory receptor that down modulates immune responses and has been a successful pharmacologic target for certain cancers; however, complications arising from disruption of normal immune function are sometimes observed, suggesting that novel approaches are needed. One approach could involve the manipulation of PD-1 gene expression in human T cells, but to do this, the transcriptional and epigenetic mechanisms regulating PD-1 gene expression in humans, which are not well characterized, must be defined. This application seeks to provide an in-depth analysis of the mechanisms that regulate PD-1 gene expression in human T cells, information that could be ultimately used to manipulate its expression.

PI_NAMEs: BOSS, JEREMY M. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Antibodies;antigen-specific T cells;Antigens;Architecture;ATAC-seq;Autoimmunity;BCL6 gene;Binding;Binding Sites;Biochemical;Biological Assay;Biological Models;bisulfite sequencing;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin;chromosome conformation capture;Chromosomes;Chronic;chronic infection;Clinic;Complex;CRISPR/Cas technology;Cyclosporine;cytokine;Data;Data Reporting;Development;DNA;Elements;Enhancers;Environment;Epigenetic Process;epigenomics;Event;exhaust;exhaustion;Experimental Genetics;experimental study;Exposure to;Family member;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Genomics;Helper-Inducer T-Lymphocyte;High-Throughput Nucleotide Sequencing;HIV;HIV Antigens;Human;human data;Immune;immune activation;immune checkpoint blockade;immune function;Immune response;immune-related adverse events;Immunologics;immunoregulation;improved;Individual;Infection;Informatics;insight;IRF4 gene;Jurkat Cells;Knock-out;Knowledge;Ligands;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Medical;Memory;Methodology;migration;Modeling;Molecular;mouse model;Mus;Nobel Prize;novel;novel strategies;nuclear factors of activated T-cells;Participant;Pathology;Pathway interactions;Peripheral;pharmacologic;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;Promoter Regions;Publishing;receptor;Regulation;Regulatory Element;Repression;Role;Signal Transduction;Specificity;STAT3 gene;success;Surface;System;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Tonsil;tool;transcription factor;Virus Diseases;Work

PROJECT_TITLE: Regulation of Human PD-1 Gene Expression

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Immunotherapy;Prevention;Skin Cancer

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Major risk factors for melanoma include fair skin and a history of sunburns, yet incomplete understanding of how different skin pigments and types of ultraviolet sunlight (UVA, UVB) contribute to melanoma progression has hindered efforts to curb disease incidence. In this application, we will use models genetically representative of human melanoma to determine how different skin pigments and forms of UV light contribute to melanoma progression. This work will identify deficiencies in the biological mechanisms that protect us from the sun, which could be mitigated to improve melanoma prevention strategies and patient outcomes.

PI_NAMEs: BURD, CHRISTIN E (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Alleles;Biological;Biological Process;BRAF gene;Cell Line;Cells;combat;Cutaneous Melanoma;Data;Data Set;Development;Disease;Disease Progression;DNA;DNA lesion;DNA Repair;DNA Sequence Alteration;Dose;Etiology;exome sequencing;experimental study;Exposure to;Gene Mutation;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genome;genomic profiling;Genotoxic Stress;Growth;Human;human disease;immune cell infiltrate;Immunotherapeutic agent;improved;in vivo;Incidence;Individual;Intervention;irradiation;Knowledge;Mediating;Melanins;melanocyte;Melanoma;Melanoma Cell;Metabolic;Metastatic Melanoma;Modeling;Mus;Mutagenesis;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Neonatal;Newborn Animals;Nucleotide Excision Repair;Oncogenes;Oxidation-Reduction;Pathology;Pathway interactions;Patient-Focused Outcomes;Pattern;pheomelanin;Physiological;Physiological Processes;Pigmentation physiologic function;Pigments;Prevention strategy;Production;Prognosis;Recording of previous events;Relative Risks;repaired;Research;Residual state;response;Risk;Risk Factors;Role;Site;Skin;Skin Pigmentation;Sun Exposure;Sunburn;Sunlight;Sunscreening Agents;System;Testing;the sun;Transcription-Coupled Repair;transcriptome sequencing;transcriptomics;tumor;tumor growth;tumor microenvironment;tumorigenesis;tumorigenic;ultraviolet;Ultraviolet A radiation;Ultraviolet B Radiation;ultraviolet damage;ultraviolet lesions;Ultraviolet Rays;UV carcinogenesis;UV Mutagenesis;UV protection;UV Radiation Exposure;UV response;Work

PROJECT_TITLE: Mechanisms of UV-Mediated Melanoma Development

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: ALBANY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: NARRATIVE Cardiovascular diseases such as atherosclerotic vascular disease, is the leading cause of death. Current studies suggest that persistent inflammation is an important driving force in the progression of this vascular disease. This project will provide a new understanding of age-related mechanisms that contribute to why inflammation is not controlled and will provide new avenues for the treatment of atherosclerosis.

PI_NAMEs: FREDMAN, GABRIELLE  (contact);MACNAMARA, KATHERINE C.

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Address;age related;age related changes;aged;Aging;aging process;Atherosclerosis;Basophils;Blood;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cells;Cholesterol;Coronary artery;Diet;Disease;driving force;Effector Cell;efficacy evaluation;eosinophil;Equilibrium;Etiology;Exhibits;Fatty acid glycerol esters;GPR18 receptor;granulocyte;Granulopoiesis;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Immune;Impairment;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;insight;Leukotriene B4;Leukotrienes;Link;Lipids;Lymphocyte;Lymphoid;Mediator;middle age;mortality;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;Necrosis;neutrophil;novel strategies;novel therapeutics;old mice;Output;pathological aging;Pharmaceutical Preparations;Phenotype;Physiological;Process;Production;programs;Prostaglandins;receptor;Regimen;Resolution;restraint;Risk Factors;Signal Transduction;Testing;Thromboxanes;Vascular Diseases;Work

PROJECT_TITLE: Inflammation-resolution impairments in aging and atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Data Science

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Columbia University proposes to consolidate their three NIEHS T32 training grants into a single, unified program. Trainees will pursue training in mechanisms of disease, environmental epidemiology, or climate and health. All students will receive foundational training in the study of health throughout the life course, the exposome, and data sciences, which will prepare them to solve major environmental health science challenges.

PI_NAMEs: FACTOR-LITVAK, PAM R;MILLER, GARY W (contact);PERZANOWSKI, MATTHEW S

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Advanced training in environmental health and data science: molecules to populations

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative The major limitations of DNA targeting drugs that are used in clinics today for treating cancer include life threatening toxicity, acquired resistance and occurrence of secondary cancers. These problems mostly stem from the ability of DNA targeting drugs to indiscriminately bind to cellular DNA or other non-DNA macromolecules resulting in DNA damage. In this proposal, we provide compelling evidence that development of new DNA interacting drugs that display high sequence/region specificity, do not directly damage the DNA and take advantage of DNA-related processes that tumor cells use but not the normal cells could have favorable therapeutic outcomes. We propose that a novel DNA targeting drug that we have recently developed meets these criteria and therefore, will not only inhibit tumor growth but will also will enhance the efficacy of the current targeted therapy and prolong survival of the breast cancer patients.

PI_NAMEs: RAO, MANJEET KUMAR (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Adjuvant;Affinity;anti-cancer;anti-tumor agent;Apoptosis;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Biophysics;Breast Cancer Patient;breast cancer survival;cancer cell;Cancer Center;cancer therapy;Carbazoles;carcinogenesis;CDC6 gene;CDK4 gene;Cell Cycle;Cell Death;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Characteristics;Chemicals;chemotherapy;Clinic;clinical development;Clinical Research;Coal Tar;Data;Dependence;Development;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Pathway;DNA Sequence Alteration;DNA sequencing;Doxorubicin;drug development;Drug Targeting;Drug usage;Ensure;Estrogen receptor positive;Frequencies;Funding;Future;Genes;genome-wide;Goals;Growth;HMGA1 gene;Human Genome;improved;in silico;inhibitor;Island;knock-down;Legal patent;Life;Ligands;macromolecule;Malignant Breast Neoplasm;Malignant Neoplasms;Matrix Attachment Regions;Modeling;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;novel strategies;novel therapeutics;Organoids;overexpression;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Play;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;pre-clinical;Pre-Clinical Model;preservation;Proliferating;Proteins;Psoriasis;Regimen;repaired;Reporting;Resistance;response;Role;scaffold;Second Primary Cancers;Specificity;stem;Structure;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapy outcome;therapy resistant;Toxic effect;translational potential;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor growth;Tumor-Associated Process;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel approach of targeting AT-rich S/MAR regions for treating therapy resistant breast cancers

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative The current proposal will investigate the relations between developmental changes in white matter fiber bundles and functional responses to faces using a multimethod approach with infants. We will draw a full picture of brain organization and sensitive periods underlying face processing ability identifying developmental changes in structure-function coupling. The results of these studies will constitute a premise for the examination of changes in the cerebral architecture resulting from specific training with faces.

PI_NAMEs: CONTE, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Address;Adult;Age Months;Anisotropy;Architecture;Area;autism spectrum disorder;Award;Axon;Brain;Brain region;Cerebrum;Characteristics;Computer software;Coupling;Custom;Data;data acquisition;density;Development;Diffusion Magnetic Resonance Imaging;Discrimination;Early Diagnosis;Early treatment;Electroencephalography;Ensure;Error Sources;Face;face perception;Face Processing;Fiber;Functional Magnetic Resonance Imaging;Goals;Head;high risk;high risk infant;Imaging Techniques;improved;Individual;infancy;Infant;innovation;insight;interest;Investigation;Knowledge;Learning;Life;Light;Link;Longitudinal Studies;Measures;Mentors;Mentorship;Methods;Modeling;multimodality;myelination;neural;neural patterning;neuroimaging;Pathway interactions;Pattern;Phase;programs;Property;Protocols documentation;Radial;reconstruction;Research;response;Risk;Scalp structure;Scientist;Shapes;Signal Transduction;skills;Source;source localization;structural imaging;Structure;Structure-Activity Relationship;System;Testing;tool;tractography;Training;transmission process;Variant;Visual;white matter

PROJECT_TITLE: Development of Face-Processing Abilities in Infants: Structural and Functional Brain Changes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE There is a critical need to improve weight loss treatment outcome for adolescents with overweight and obesity. Extant treatments for adolescent obesity do not take into account the aberrant decision-making processes that characterize adolescence and contribute to problematic eating behaviors. The proposed study will investigate aberrant decision-making as a predictor of treatment outcome for adolescent obesity, providing direction for treatment development.

PI_NAMEs: MANASSE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Adolescence;Adolescent;Adolescent obesity;adult obesity;Affect;Aftercare;Age;Automobile Driving;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Biological;Body mass index;Body Weight Changes;Body Weight decreased;cardiovascular disorder risk;career;Child;Clinical;Clinical Trials;clinically significant;Conduct Clinical Trials;Data;Data Analytics;Decision Making;deprivation;design;Development;Diabetes Mellitus;dietary restriction;discount;discounting;Eating;Eating Behavior;Eating Disorders;effective therapy;Energy consumption;Evaluation;Exanthema;excessive weight gain;experience;feasibility testing;Feeling;follow-up;Food;Future;Goals;Hyperphagia;improved;Impulsivity;Individual;Intervention;Knowledge;Lead;Left;Link;loss of control over eating;Macronutrients Nutrition;Malignant Neoplasms;Measurement;Measures;Mediating;Mentors;Methods;Modality;Modeling;negative affect;novel;Nutritional;Obesity;obesity in children;obesity treatment;Outcome;Overweight;Parents;Participant;Pattern;peer;Prediction of Response to Therapy;Prevalence;prevent;Process;Public Health;recruit;Regulation;Research;Research Personnel;response;Rewards;Role;Sampling;skills;Statistical Methods;success;targeted treatment;Testing;Theoretical model;theories;therapy design;therapy development;Training;Treatment Efficacy;Treatment outcome;Unhealthy Diet;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Does aberrant decision-making prevent success in adolescent behavioral weight loss treatment?


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Despite the mounting genetic discoveries for neurodevelopmental and psychiatric disorders (NPD), effective treatments remain beyond reach due to a lack of understanding of the pathophysiology of NPD. This proposal seeks to establish an Assay and Data Generation Center (ADGC) within the framework of the NIMH Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes (SSPsyGene) Consortium. Our ADGC will generate data from ~200 high-confidence NPD risk genes on multiple genetic backgrounds, including understudied African American iPSC lines, to enable robust inferences of potential cross- disorder and cross-population biological convergence relevant to NPD.

PI_NAMEs: DUAN, JUBAO ;MULLE, JENNIFER GLADYS;PANG, ZHIPING P. (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Acceleration;African American;Alleles;Atlases;autism spectrum disorder;Bar Codes;base editing;base editor;Biological;Biological Assay;Biological Models;Biology;Bipolar Disorder;Cell Line;cell type;Cells;clinically actionable;Coculture Techniques;Collaborations;Communities;Computer Models;cost effective;Cytosine;Data;Data Analyses;data integration;Data Set;Disease;disease mechanisms study;effective therapy;Electrophysiology (science);European ancestry;excitatory neuron;exome sequencing;Female;Foundations;Functional disorder;functional genomics;Future;gamma-Aminobutyric Acid;gene function;gene network;Generations;Genes;Genetic;genome wide association study;Genomics;Glutamates;Human;human induced pluripotent stem cells;Image;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitory neuron;Knowledge;knowledge base;knowledge integration;loss of function;Major Depressive Disorder;male;Mental disorders;Messenger RNA;Methods;Modeling;Molecular;Morphology;multimodality;multiplexed imaging;mutant;National Institute of Mental Health;neural;neural model;Neurobiology;Neurodevelopmental Disorder;neurodevelopmental effect;Neurons;Neurosciences;next generation;Nonsense Codon;Nonsense-Mediated Decay;novel;optical imaging;optical sensor;patch clamp;patch sequencing;Pathway Analysis;Patients;Penetrance;Phenotype;Population;Property;Protein Truncation;rare variant;Reproducibility;Research;Resources;response;risk variant;scale up;Schizophrenia;sensor;single-cell RNA sequencing;stem cell biology;stem cell model;Synapses;synaptic function;Synaptic Transmission;System;Time;transcriptomics;Translating;Validation;Variant;Work

PROJECT_TITLE: Assay and Data Generation Center (ADGC) for the Model of iPSC-derived Neurons for NPD (MiNND)


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Dysregulated NLRP3 inflammasome signaling causes detrimental pathologies of the expanding spectrum of sterile inflammatory diseases, including Cryopyrinopathies, Gout, Silicosis, Asbestosis, Atherosclerosis, Diabetes, Alzheimer’s disease, Cancer, kidney dysfunction and others. However, the mechanisms that control this NLRP3 inflammasome response are still poorly understood. In this application, we propose to define a novel identified NLRP3 binding partner, which is absolutely required for NLRP3 inflammasome activation specifically in human macrophages, which may provide novel targets for developing improved therapies for patients.

PI_NAMEs: DORFLEUTNER, ANDREA ;STEHLIK, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Asbestosis;associated symptom;Atherosclerosis;ATP phosphohydrolase;Binding;Biochemical;Biological;CASP1 gene;Cell Death;Cells;Cellular Stress;Complex;CRISPR/Cas technology;cytokine;Cytoplasm;debilitating symptom;design;Development;Diabetes Mellitus;Disease;Event;Gout;Health;Homeostasis;Human;humanized mouse;IL18 gene;Immune;Immune response;Immunologic Receptors;Immunology;improved;in vivo;Individual;inducible gene expression;Infection;Infectious Agent;Inflammasome;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interleukins;kidney dysfunction;Knock-out;knockout gene;Knockout Mice;Licensing;Link;Macrophage;Malignant Neoplasms;marenostrin;Mediating;Microbe;Modeling;Modification;Molecular;mouse genetics;Mus;mutant;Mutation;novel;novel therapeutics;Outcome;pathogen;Pathology;Patients;Pattern;Pattern recognition receptor;Periodicals;Phenocopy;polymerization;Polymers;Positioning Attribute;prevent;Proteins;receptor;recruit;Regulation;Research;response;Role;sensor;Sensory;Signal Transduction;Silicosis;Sterility;stress granule;Syndrome;Tissues;tool;treatment strategy;wound healing

PROJECT_TITLE: A novel mechanism for NLRP3 inflammasome activation in human macrophages

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Immunotherapy;Inflammatory Bowel Disease;Liver Disease

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

PHR: Project Narrative The gut is a key immunological organ, where host-microbe interactions shape both local and systemic immune tolerance. Prevailing immunological views conflate the two organs that comprise the gut—the small and large intestines (or SI and LI)—yet recent evidence from our labs, and others, suggest that T cells infiltrating the SI and LI utilize unique sets of ligand-regulated nuclear receptors (NRs) to tether key regulatory functions, including IL-10 expression, to discrete bile- and microbe-derived metabolite classes. In this proposal, we use both agnostic and targeted approaches to interrogate the mechanisms by which NRs execute T cell regulatory functions in the SI vs. LI, thus laying a foundation for understanding compartmentalized immune regulation in the gut.

PI_NAMEs: PIPKIN, MATTHEW EUGENE;SUNDRUD, MARK SCOTT (contact);WEAVER, CASEY T

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: absorption;Amplifiers;antagonist;Anti-Inflammatory Agents;Antigens;Bacteria;Bile Acid Biosynthesis Pathway;Bile Acids;Bile fluid;Binding;Biochemical;Butyrates;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Circulation;Classification;Colon;constitutive androstane receptor;cytokine;Data;design;Development;Drug Metabolic Detoxication;Duodenum;Effector Cell;Enteral;Enterocytes;Enterohepatic Circulation;Enzymes;Estrogens;Foundations;FOXP3 gene;functional genomics;Gallbladder;Gene Expression;Gene Expression Regulation;Genetic Screening;Genetic Transcription;Genome;Genomics;Glucocorticoid Receptor;Health;Hepatocyte;Histone Deacetylase Inhibitor;Homeostasis;host-microbe interactions;Human;IL10 gene;ileum;Immune;Immune Tolerance;Immunologics;Immunology;immunoregulation;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-10;Intestines;Large Intestine;Ligand Binding Domain;Ligands;Link;lipophilicity;Liver;Location;Lymphocyte;Lymphocyte Subset;Maps;member;Metabolic;Metabolism;Microbe;microbial;microbiota;Molecular;Mucosal Immunity;Mucositis;Mucous Membrane;Mus;novel;novel strategies;Nuclear;Nuclear Hormone Receptors;Nuclear Receptors;Organ;Orphan;Peripheral;Production;programs;receptor;Receptor Activation;Regulation;Regulatory T-Lymphocyte;Reporting;Residual state;response;RNA Interference;RNA interference screen;Role;screening;Secondary to;sensor;Shapes;small bowel Crohn's disease;Small Intestines;steroid hormone;T cell infiltration;T cell response;T-Lymphocyte;targeted treatment;Testing;Thyroid Hormones;Toxic effect;transcription factor;Ulcerative Colitis;Validation;Vitamin D3 Receptor;Volatile Fatty Acids;Wild Type Mouse;Xenobiotics

PROJECT_TITLE: Nuclear Receptor Networks in Mucosal Immune Regulation


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  More than 100 million new skin scars appear annually in the United States, and scars may cause severe emotional distress and physical disability. Although many products are marketed for scar prevention, their results are modest. If successful, this project will generate major new insights into the cellular and molecular mechanisms controlling scar formation and skin regeneration in mammals and identify new strategies to prevent scar formation in humans.

PI_NAMEs: LEUNG, THOMAS H. (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adult;afferent nerve;Antibodies;Architecture;Area;Biological Assay;Biological Process;Cations;cell type;Cells;Cicatrix;Cutaneous;cytokine;Data;Dendritic Cells;Dermal;Distant;Ear;emotional distress;Exhibits;Fibroblasts;Fibrosis;Future;gene product;Genes;Goals;Hair;Hair follicle structure;healing;Human;IL17 gene;Immune;Immunology;improved;In Vitro;in vivo;injured;insight;interleukin-23;Knockout Mice;Light;Mammals;Marketing;Mediating;Modeling;Molecular;mouse model;Mouse Protein;Mus;Natural regeneration;Nerve;Neuroimmune;Neurons;neutrophil;Neutrophil Infiltration;novel therapeutics;old mice;optogenetics;Organ;Parabiosis;paracrine;pharmacologic;physically handicapped;Physiological;prevent;Prevention;Production;receptor;Recombinant Proteins;reconstitution;recruit;Regenerative pathway;replication factor C;Reporting;response;Science;Sebaceous Glands;Serum;Signal Pathway;single cell genomics;single-cell RNA sequencing;Site;Skin;Skin injury;skin regeneration;Skin repair;skin wound;Skin wound healing;Spinal Ganglia;Structure;tau Proteins;Testing;therapeutic development;Thick;tissue regeneration;Tissues;Transcript;United States;Vertebrates;Work;wound;Wound models;γδ T cells

PROJECT_TITLE: Neuroimmune Control of Scarless Skin Regeneration

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Laparoscopic surgery is the standard of care in high-income countries for many cancer procedures but is largely inaccessible in low- and middle-income countries. We describe a multi-disciplinary collaboration between biomedical engineers, surgeons, oncologists, global healthcare delivery teams and business developers to move a low-cost and durable laparoscopic system to the next stage. Construction of the laparoscopic system will be demonstrated in Uganda, its clinical performance will be tested in a clinical First-in- Human study and regulatory approval will be achieved to bring this system to commercialization in Uganda.

PI_NAMEs: FITZGERALD, TAMARA N (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Abdomen;abdominal wall;Address;authority;Biomedical Engineering;Biopsy;Businesses;cancer care;cancer diagnosis;cancer therapy;Carbon Dioxide;cardiovascular collapse;chemotherapy;Chest;Cidex;Classification;Client satisfaction;Clinical;Collaborations;Color;commercialization;Computers;Contract Services;cost;Country;Data;design;detector;Devices;Electricity;Engineering;Ensure;Equipment;Excision;experience;Fiber Optics;first-in-human;Foundations;Gases;global health;Good Manufacturing Process;health care delivery;Health Expenditures;Home;Hospitals;Human Resources;human study;Image;Immersion;improved;Income;Industrialization;Infection;Instruction;instrument;interdisciplinary approach;Interdisciplinary Study;Intra-abdominal;Laparoscopes;Laparoscopic Surgical Procedures;laptop;Lawyers;Length of Stay;Lifting;Light;light emission;Link;loss of function;low and middle-income countries;Maintenance;Malignant neoplasm of abdomen;Malignant Neoplasms;manufacture;manufacturing process;manufacturing technology;Maryland;Measures;Mechanics;Medical;Mentors;metal oxide;Monitor;Oncologist;Operating Rooms;operation;Operative Surgical Procedures;Pain;Pathologic;Pathway interactions;patient safety;Patients;Performance;Pharmaceutical Preparations;porcine model;Poverty;Power Sources;predicting response;pressure;prevent;primary outcome;Procedures;Process;product development;Production;Protocols documentation;prototype;Qualifying;quality assurance;Quality Control;Radiation;Recovery;Regulation;repaired;Research Institute;Resource-limited setting;Resources;Rural Hospitals;Safety;safety and feasibility;secondary outcome;Semiconductors;Shipping;social stigma;Source;standard of care;success;Surgeon;Surgical incisions;System;Technology;Testing;Time;Tissues;Training;tumor;Uganda;Universities;willingness;Work;Wound Infection

PROJECT_TITLE: KeyScope: The Key to Sustainable Cancer Diagnosis and Treatment in Uganda


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance to Public Health This project aims to create a “Trojan horse” circuit, consisting of proteins engineered to regulate each other. This circuit will be introduced into cells, assess cellular states, and then mobilize the immune system against the cells in a cancerous state. It will demonstrate the possibility of addressing cancers that are difficult to treat with conventional methods.

PI_NAMEs: GAO, XIAOJING J (contact);WINSLOW, MONTE MEIER

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Ablation;Abscopal effect;Address;Adverse effects;Amino Acid Sequence;Antibodies;Antigen Targeting;Antigen-Presenting Cells;Antineoplastic Agents;Binding;Biological Process;Biological Products;bioluminescence imaging;cancer cell;Cancer Detection;Cancer Model;cancer type;Cancerous;Cell Death;Cell Transplantation;cell type;Cells;chemotherapy;Collection;conventional therapy;Cultured Cells;Data;Dedications;design;Distant;DNA-Protein Interaction;Engineering;Equus caballus;Event;Excision;Exhibits;experience;Generations;Genes;Goals;Grant;Human;Immune;Immune response;Immune system;Immunity;immunogenic;Immunologic Stimulation;Immunotherapy;improved;In Vitro;in vivo;Innovative Therapy;intercellular communication;Intervention;KRAS oncogenesis;KRAS2 gene;laboratory experience;Learning;Lentivirus Vector;Libraries;Malignant Neoplasms;Mediating;Medicine;Methods;Modality;Molecular;mouse model;mutant;Mutation;neoantigen vaccine;neoantigens;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;operation;Outcome;Output;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;Peptide Hydrolases;Performance;Pharmaceutical Preparations;Philosophy;Physicians;Positioning Attribute;pre-clinical;Primary Neoplasm;Process;programs;Protein Engineering;Protein Secretion;Proteins;Public Health;Quality of life;Radiation therapy;RAS driven cancer;Research Personnel;sensor;Signal Transduction;small molecule;synergism;System;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Time;tool;tumor;Vaccination;Vaccines;Variant

PROJECT_TITLE: Program the Immune System against RAS-driven Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: LINCOLN

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Using a multidisciplinary approach we will combine centralized immunogen design with TMV conjugation and plant-based expression systems to create a novel universal influenza vaccine candidate. We will test these approaches in a systematic series of experiments that examines immune correlates of protection, protection against lethal influenza challenges in both mouse and ferret models, and vaccination in the context of pre- existing anti-influenza immunity. We are confident that this approach will lead to a single immunization with a universal vaccine that provides life-long protection and eliminates influenza virus infections.

PI_NAMEs: MCCORMICK, ALISON ANNE;WEAVER, ERIC A (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Affect;age group;anti-influenza;Antibody-mediated protection;Antigens;bioprocess;Biotechnology;Cellular Immunity;Centers for Disease Control and Prevention (U.S.);Characteristics;chemical conjugate;Clinical Trials;combat;comparative efficacy;Computing Methodologies;Consensus;Consensus Sequence;cross reactivity;Data;design;Development;Discipline;Disease;disease model;Dose;experimental study;Ferrets;Fluzone;Foundations;Future;Genes;Goals;Human;Humoral Immunities;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunologics;improved;Inactivated Vaccines;infection rate;Influenza;Influenza A virus;Influenza A Virus, H3N2 Subtype;influenza infection;influenza outbreak;influenza virus strain;influenza virus vaccine;influenzavirus;innovation;interdisciplinary approach;Intramuscular;Kentucky;manufacture;meetings;Methods;Modeling;mouse model;Mus;novel;pandemic disease;pandemic influenza;pathogen;Pathogenicity;Peptide Vaccines;Peptides;Persons;Plants;Plasmid Cloning Vector;practical application;pre-clinical;Production;protein expression;protein purification;Proteins;Public Health;rational design;Recombinants;Research;research clinical testing;Route;Safety;scale up;Schedule;seasonal influenza;Series;Speed;Subunit Vaccines;Surface;System;Technology;Testing;Tobacco Mosaic Virus;Tobacco use;Translating;translational potential;United States National Institutes of Health;universal influenza vaccine;universal vaccine;Vaccination;vaccine candidate;vaccine efficacy;vaccine formulation;Vaccine Production;Vaccines;Variant;Virus;Work;World Health Organization

PROJECT_TITLE: Rapid Manufacturing of a Universal Flu Vaccine Using TMV-conjugated Centralized Antigens


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We propose an ESCC diagnostic strategy comprising a single-use swallowed retrievable sponge-capsule to collect esophageal cells for biomarker analysis, coupled with a portable microfluidic chip device for automated POC sample processing and DNA methylation detection. This strategy does not require endoscopy (EGD), can be administered in rural settings without the need for electricity or persons with medical training, and uses a portable analytic chip. The sponge is cheaper, less invasive, safer, and faster than EGD; the microchip integrates DNA extraction, bisulfite DNA conversion, and methylation analysis into a single POC device.

PI_NAMEs: MELTZER, STEPHEN J (contact);WANG, TZA-HUEI JEFF

PROJECT_TERMS: Area;Benign;Biological Assay;Biological Markers;Biopsy;bisulfite;Cancer Detection;candidate marker;capsule;Cells;Cellular Phone;Cessation of life;Clinical;Cold Chains;Collection;Coupled;Cytolysis;Data;Defect;Deglutition;design;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic strategy;Disadvantaged;Disease;disorder control;DNA;DNA Integration;DNA Methylation;DNA purification;Dryness;Electricity;Endoscopy;Energy Supply;Engineering;Esophageal Squamous Cell Carcinoma;Esophageal Tissue;Esophagus;Evaluation;Feedback;Fluorescence;follow-up;Freeze Drying;Healthcare;high risk;Histology;Histopathology;Hour;Human Resources;Hypermethylation;Impairment;instrument;invention;Light;low and middle-income countries;Magnetism;Malignant neoplasm of esophagus;Malignant Neoplasms;Measurement;Measures;Medical;meetings;Methylation;methylation biomarker;methylation testing;microchip;Microfluidic Microchips;Microfluidics;minimally invasive;Modeling;Molecular;molecular marker;mortality;Mucous Membrane;Patients;Persons;Pilot Projects;point of care;point-of-care diagnosis;Porifera;portability;rapid diagnosis;Reagent;remote location;rural setting;sample collection;Sampling;screening;sealant;Sensitivity and Specificity;Services;Site;Specimen;Specimen Handling;Speed;Techniques;Temperature;Testing;Therapeutic;Time;Training;tumor;Uganda;Universities;University Hospitals;Waxes

PROJECT_TITLE: Point-of-Care Diagnosis of Esophageal Cancer in LMICs


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Maternal Health;Microbiome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative  Due to the opioid crises in the United States, many pregnant women are using opioids or are treated with opioid maintenance therapy drugs like buprenorphine. Buprenorphine exposure during pregnancy and parturition may alter the endogenous opioid regulation of the maternal brain network, which could explain the reduced maternal care and increased offspring mortality and altered long-term outcome of the offspring that is observed in animal studies. Our translational rodent model will help illuminate consequences of gestational opioid exposure for the maternal brain, maternal care and the gut-brain axis and explore interventions to help improve the health and outcome of mothers and their offspring.

PI_NAMEs: BRUMMELTE, SUSANNE  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: 3-Dimensional;Acute;Address;adverse outcome;Affect;Agonist;Animal Model;Animals;antagonist;Area;Behavior;Behavior Control;beta diversity;biological adaptation to stress;Birth;Brain;Brain region;Buprenorphine;caregiving outcomes;Caring;Cell Nucleus;Child;child bearing;Clinical;clinically relevant;cohort;comparison control;Conceptions;Data;Development;Dopamine;effectiveness evaluation;endogenous opioids;Ensure;Epidemic;Exposure to;Female;fetal opioid exposure;Fostering;Glutamates;Goals;gut microbiome;gut-brain axis;Health;Heroin;High Pressure Liquid Chromatography;Human;Hypothalamic structure;Illicit Drugs;Image;Imaging Techniques;improved;Incentives;Infant;infant outcome;Intervention;kappa receptors;Knowledge;Life Experience;Light;Maps;marginalized population;Maternal Behavior;maternal caregiving;Maternal Exposure;maternal outcome;Mediating;medication for opioid use disorder;Methadone;microbiome;microbiome alteration;microbiota;Microscopy;Morphine;mortality;motherhood;Mothers;mu receptors;neglect;neurobiological mechanism;Neurobiology;neurochemistry;Neurons;Neuropeptides;Neurotransmitters;Nulliparity;offspring;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid exposure;Opioid replacement therapy;opioid use;opioid use disorder;optimal treatments;Organ;Outcome;Oxytocin;pain sensitivity;Pattern;Perception;Perinatal;Perinatal Exposure;perinatal period;Pharmaceutical Preparations;Pharmacodynamics;Physiology;Play;Postpartum Period;Pregnancy;Pregnant Women;prevent;Prevention strategy;Public Health;pup;Rattus;receptor;Regulation;Reporting;Research;Resolution;response;reward circuitry;Rewards;Rodent;Rodent Model;Role;Science;sex;Solvents;Survival Rate;synthetic opioid;System;Translations;United States;Woman

PROJECT_TITLE: The effects of gestational opioid exposure on the maternal brain, behavior and microbiome

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Osteoporosis;Patient Safety;Prevention

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Project Narrative The lack of clinically available tools for identification of bone abnormalities in patients who undergo spine fusion surgery contributes to high rates of complications after surgery. This prospective study will investigate a new technique, based upon standard clinical MRI scans, to detect abnormal bone in patients before surgery, monitor changes in bone and predict complications that occur after surgery. The long-term goals of our research are to improve identification of patients at high risk for complications after surgery and provide knowledge that will help plan follow-up treatment studies.

PI_NAMEs: STEIN, EMILY MARGARET (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Age;Anabolic Agents;Biopsy;bone;bone quality;Characteristics;Clinical;clinical care;clinical practice;Clinical Treatment;Clinical Trials;Complex;cost;Data;Detection;Diagnosis;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Enrollment;Entropy;Evaluation;Failure;follow-up;Fracture;Future;Goals;Health;Health Care Costs;Heterogeneity;high risk;Hip region structure;improved;improved outcome;Incidence;instrument;Intervention;Intervention Trial;Knowledge;Magnetic Resonance Imaging;Measurement;Measures;Methods;Monitor;Morbidity - disease rate;Morphologic artifacts;MRI Scans;novel;novel marker;older adult;Operative Surgical Procedures;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Outcome;Patient-Focused Outcomes;Patients;Perioperative;Peripheral;Pharmaceutical Preparations;Population;Postmenopause;Postoperative Complications;Postoperative Period;Prevalence;prospective;Prospective Studies;Research;Resolution;Risk;screening;Screening procedure;skeletal;skeletal abnormality;Spinal;Spinal Diseases;Spinal Fusion;spine bone structure;Spine surgery;substantia spongiosa;success;Techniques;Testing;Texture;tool;Treatment Protocols;United States;Vertebral column;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: MRI Bone Texture: A Novel Biomarker for Assessment of Bone Quality and Prediction of Complications in Patients Having Spine Fusion Surgery

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: No practical noninvasive antemortem test exists to detect cervid, human, or any, prion disease. We have developed simple, rapid, specific and highly sensitive in vitro assays to detect blood-borne prions (9-11). In this competing renewal we will quantitate the temporal distribution and specific blood cell phenotypes critical to prionemia in human and cervid blood samples.

PI_NAMEs: MATHIASON, CANDACE K. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affect;Agriculture;American;Amyloid;Animals;Asia;Biological;Biological Assay;Blood;Blood Cells;Blood Platelets;Blood specimen;Blood Transfusion;Canada;Cell Fraction;Centrifugation;cervid;Chronic Wasting Disease;Chronology;Clinical;Collaborations;Collection;Consumption;cost effective;Coupled;Creutzfeldt-Jakob Syndrome;Deer;Detection;Disease;DNA Sequence Alteration;Drosophila genus;Economics;Environment;Europe;Excretory function;Genetic;Genetic Carriers;Grant;Health;Hematogenous;Human;improved;in vitro Assay;in vivo;Industry;Infection;inhibitor;Kinetics;Label;Letters;Leukocytes;magnetic beads;Methodology;Methods;Monitor;mutation carrier;Nature;Oral;Pathogenesis;Patients;Phenotype;Population;pre-clinical;Prevalence;prevent;Prion Diseases;prion seeds;Prions;prototype;PrP;Reindeer;Research;Risk;Safety;Sampling;Scrapie;Sheep;Sorting;Testing;Therapeutic;Time;Tissues;trafficking;Transgenic Mice;Translating;translational impact;transmission process;Variant;Zoonoses

PROJECT_TITLE: Detection and Characterization of Blood-borne Prions

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The overall aim of this project is to determine the effectiveness of a smartphone app designed to help cancer patients quit smoking. If successful, this intervention would provide an effective and highly accessible public health intervention for cancer patients.

PI_NAMEs: BRICKER, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Address;Adult;Age;Anxiety;arm;Biochemical;cancer care;cancer diagnosis;Cancer Patient;cancer type;Cellular Phone;Cigarette Smoker;Clinic;Clinical;comparative effectiveness;Complex;Death Rate;demographics;design;Diagnosis;disorder risk;Effectiveness;effectiveness evaluation;evidence base;Feeling;follow-up;Future;General Population;Head and neck structure;Hospitals;improved;Insurance Coverage;Intervention;intervention cost;Knowledge;Lung;Malignant Neoplasms;Mediating;Mental Depression;Methods;National Comprehensive Cancer Network;Oncologist;Outcome;Participant;Population;Prevalence;Process;Provider;psychologic;psychosocial;public health intervention;public health relevance;Randomized;randomized effectiveness trial;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Recurrent disease;Reporting;retention rate;Risk;Sample Size;Scientific Advances and Accomplishments;Second Primary Cancers;Services;sex;Shame;smartphone application;Smoke;Smoker;Smoking;smoking cessation;smoking prevalence;social;social media;social stigma;Source;Special Population;Specialist;Spouses;Surveys;System;Testing;therapy design;Time;Tobacco;tobacco cessation intervention;Training;Treatment Effectiveness;user centered design

PROJECT_TITLE: Quit2Heal: Rigorous Randomized Trial of a Smartphone Application to Help Cancer Patients Stop Smoking


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Physician-scientists are uniquely suited for the bidirectional translation of basic science research and clinical medicine. With the exponential increase in biomedical knowledge, the proliferation of new technologies, and the aging of the biomedical research workforce, the need to train diverse physician-scientists who can capitalize on these advances to improve prevention, diagnosis, and treatment of disease is greater than ever. The Medical Scientist Training Program at UT Southwestern Medical Center is helping foster the next generation of physician-scientists who will improve human health through biomedical research.

PI_NAMEs: ZINN, ANDREW R. (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Medical Scientist Training Program at University of Texas Southwestern Med Ctr -

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

PHR: PROJECT NARRATIVE This project will provide timely methodological advancements to efficiently and accurately analyze histopathological information using deep learning models. The results of this study will remove current methodological and computational bottlenecks in the application of deep learning technologies in digital pathology. Therefore, this project will have a significant impact on the current standard of patient care by effectively assisting pathologists in clinical practice and integrating histopathological information with other clinical and molecular data to improve patients' diagnoses, prognoses, and treatments.

PI_NAMEs: HASSANPOUR, SAEED  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Address;Affect;Agreement;Anatomy;Architecture;Archives;Brain;Cells;Characteristics;Classification;Clinical;clinical practice;cognitive load;Colorectal Polyp;Computer Vision Systems;computing resources;Consumption;cost;Data;data resource;Data Set;Databases;deep learning;deep learning model;Diagnosis;digital;digital applications;digital pathology;Educational Curriculum;feature extraction;Fruit;generative adversarial network;Glioma;Hematoxylin and Eosin Staining Method;high resolution imaging;Histologic;histological studies;Histology;Histopathology;Image;Image Analysis;image translation;improved;Interobserver Variability;Knowledge;Label;Laboratories;Learning;lung cancer cell;machine learning method;Manuals;Medical;Medicine;Memory;Metastatic Neoplasm to Lymph Nodes;Methodology;Methods;microscopic imaging;Microscopy;Modeling;Molecular;Nature;novel;novel strategies;Pathologic;Pathologist;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Prognosis;Proxy;Reading;Resolution;Resources;Running;Sampling;Scanning;self supervised learning;Slide;Stains;standard of care;Standardization;Students;Technology;Time;Tissue Banks;Tissues;Training;translational model;Translations;whole slide imaging

PROJECT_TITLE: Advancing Digital Pathology through Novel Machine Learning Methodologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


NIH_SPENDING_CATS: Genetics;Human Genome;Microbiome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative New understanding of microbiome communities have shifted paradigms on what determines eukaryotic host health. We seek to understand how microbiomes assemble, what drives microbiome community succession and strain evolution, and how microbiome network structure confers stability and host homeostasis. We seek to understand these question by harnessing the microbiomes of microbes because with this understanding we might gain new insights into how microbiomes fail in disease, ultimately leading to new insights into how microbiomes can be modulated to develop microbiome-based therapeutics.

PI_NAMEs: JACKREL, SARA LINDSAY (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Identifying the Rules Governing Host-Microbiome Composition and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The viruses that cause influenza mutate and evolve rapidly. This makes it hard to control outbreaks and prevent infections. The proposed research will lead to a greater understanding of how and why the virus makes so many mutations. It is relevant to the public health, because it will allow for better prediction of influenza virus evolution and the development of more effective antiviral drugs.

PI_NAMEs: LAURING, ADAM  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;Amino Acid Substitution;Amino Acids;Anti-viral Agents;Biochemical;Biochemistry;Biological Assay;Birds;Codon Nucleotides;Complex;Conflict (Psychology);cost;Data;Development;Drug resistance;emerging virus;Evolution;fitness;Genetic;Genome;Goals;Human;In Vitro;in vitro Assay;Infection prevention;Influenza;Influenza A virus;Influenza A Virus, H3N2 Subtype;influenzavirus;innovation;Integration Host Factors;Kinetics;Libraries;Maps;Measurement;Measures;Modeling;molecular dynamics;Mutagens;Mutate;Mutation;mutation screening;Natural Selections;novel;Nucleosides;Nucleotides;outbreak control;pandemic disease;Pathway interactions;Pharmaceutical Preparations;Phylogenetic Analysis;Polymerase;Population;pressure;Property;protein protein interaction;Proteins;Public Health;Research;Resistance;RNA-Directed RNA Polymerase;Route;Seasons;Serial Passage;Shapes;single-molecule FRET;Site;Speed;Testing;transmission process;vaccine efficacy;Variant;Viral;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: Functional and genetic constraints on influenza virus replication and fidelity

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The NEIL1, 2 and 3 glycosylases play roles in repair of DNA base damage caused by oxidative stress. NEIL dysfunction is associated with neurological disorders and cancer. This study will reveal mechanisms of lesion detection and repair by NEIL glycosylases and aid in defining their roles in genome maintenance and gene expression.

PI_NAMEs: DAVID, SHEILA SUE (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Aging;Amino Acids;Arginine;base;Base Excision Repairs;Binding;Biological Assay;biophysical techniques;Cells;Cellular Assay;Chemistry;Codon Nucleotides;Curiosities;Defect;Deoxyribose;Detection;DNA;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;DNA Sequence Alteration;Enzymatic Biochemistry;Enzymes;Excision;experimental study;Flow Cytometry;Fluorescence Microscopy;Functional disorder;G-Quartets;Gene Expression;Genes;Genetic Transcription;Genome;genome integrity;Genomics;guanidinohydantoin;Hydantoins;In Vitro;Kinetics;Laboratories;Lesion;Link;Lysine;Maintenance;Malignant Neoplasms;malignant neurologic neoplasms;Mammalian Cell;Mediating;Molecular;Monitor;NEIL3 gene;Nervous System Disorder;Nucleic Acids;Nucleotides;Oncogenes;oxidation;Oxidative Stress;Plasmids;Play;Positioning Attribute;prevent;Process;promoter;Promoter Regions;Property;Protein Isoforms;Pyrimidines;Reaction;recruit;repaired;Reporter;response;RNA Editing;Roentgen Rays;Role;Scanning;Signal Transduction;single molecule;Single-Stranded DNA;Site;Structure;Substrate Specificity;thymine glycol;trend;Visualization

PROJECT_TITLE: Elucidating Mechanisms of Recognition and Excision of Damaged Bases by NEIL glycosylases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative:  The proposed research aims at designing, developing, and testing novel NiTi-based on MRI- compatible metamaterial technology of a depth and an ECoG electrode set for Neuropace. The development of such novel technology could result in significant benefits to patients that suffer from some medically refractory pathological conditions such as Parkinson’s disease, epilepsy, and stroke.

PI_NAMEs: ARONSON, JOSHUA PAUL;AY, ILKNUR ;BONMASSAR, GIORGIO  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: absorption;Accidents;Adopted;Alzheimer's Disease;Anatomy;Animal Testing;Arrhythmia;Biocompatible Materials;biomaterial compatibility;Brain;brain machine interface;Characteristics;Choking;Chronic;Clinical;Clinical assessments;Coiled Bodies;comorbidity;Computational Technique;Deep Brain Stimulation;deep brain stimulator;Defibrillators;Deposition;design;Development;Devices;Diagnosis;diagnostic tool;Dystonia;effectiveness evaluation;efficacy testing;efficacy validation;Electric Conductivity;electric impedance;Electric Stimulation;electrical potential;electrical property;Electrocorticogram;Electrodes;Electroencephalography;Electromagnetics;Electrophysiology (science);Epilepsy;experience;experimental study;Family suidae;Filament;Film;flexibility;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Gelfilm;General Hospitals;Generations;Goals;Head;Heating;Histology;Human;Image;Implant;implant material;implantable device;Implanted Electrodes;individual patient;innovation;Knowledge;Label;Lead;Leeches;Lifting;Literature;Location;Magnetic Resonance Imaging;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Massachusetts;Measurement;Measures;mechanical properties;Medical;Medical Device;medical implant;Medicine;Modeling;Morphologic artifacts;MRI Scans;nanoparticle;nanoscale;Nervous System Disorder;neural;neural implant;neurophysiology;neurotransmission;new technology;novel;Pacemakers;Paralysed;Parkinson Disease;Pathologic;Patients;Performance;Polymers;porcine model;Postoperative Period;prevent;Property;radio frequency;Refractory;Reporting;Research;Rest;Rodent;Safety;safety assessment;Scanning;severe injury;simulation;soft tissue;Source;Spinal Cord;Stroke;success;Surface;System;Technology;Testing;Therapeutic;Therapeutic Effect;Thick;Thinness;Time;Tissues;Torque;Trauma;Traumatic Brain Injury;Universities;vapor;vibration;virtual human

PROJECT_TITLE: Metamaterials Implants for Magnetic Resonance Imaging


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Clinical manifestations of unwanted immune response against proteins are autoimmune conditions, food allergies and immunogenicity against therapeutic proteins. Our long-term goal is to address this medical need, by inducing tolerance towards protein antigens in a directed and specific manner. The proposed research is relevant to NIH’s mission of seeking fundamental knowledge to enhance human health and relevant to public health because the proposal addresses an unmet medical need and is focused on developing novel clinical approaches to reduce and reverse such unwanted immune responses.

PI_NAMEs: BALU-IYER, SATHY VENKAT (contact);KAY, JASON G;WOHLFERT, ELIZABETH

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adopted;Adoptive Transfer;Animal Model;Antibody Response;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;base;Biological;biophysical properties;biophysical techniques;Biophysics;Blocking Antibodies;Cells;Charge;Clinical;Data;Dendritic Cells;density;design;Development;Factor VIII;Food Hypersensitivity;Foundations;Generations;Glucan 1,4-alpha-Glucosidase;Glycogen storage disease type II;Goals;Gut associated lymphoid tissue;Health;Hemophilia A;Human;Hypersensitivity;Imaging Techniques;Immune;Immune response;Immune Tolerance;immunogenicity;Immunologics;Immunotherapy;In Vitro;in vivo;innovation;interdisciplinary approach;Interleukin-10;Knockout Mice;Knowledge;Label;Lecithin;Length;Life;lipid nanoparticle;lipid structure;Lipids;lysophosphatidylserine;M cell;Mediating;Medical;Methodology;Mission;Modeling;Molecular;mouse model;Mus;nanoparticle;nanoparticle exposure;novel;Oral;oral tolerance;Outcome;Ovalbumin;particle;Particulate;Pharmaceutical Preparations;Phosphatidylserines;prevent;Property;Proteins;Public Health;Publishing;receptor;receptor binding;Regulatory T-Lymphocyte;Research;response;Role;Signal Transduction;Structure;Surface;System;Techniques;Testing;therapeutic protein;tool;trafficking;Transgenic Mice;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Lipid mediated oral tolerance

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Liver Disease;Organ Transplantation;Pediatric;Transplantation

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Adolescent/young adult kidney or liver transplant recipients have unacceptably high rates of immunosuppressant medication nonadherence and, thus, are at elevated risk for nonadherence-related organ rejection, graft loss, or death. Our research involves (1) validating a new, non-invasive Real-Time Adherence Measure based on real- time adherence data easily downloaded from electronic pillboxes to accelerate provider identification of when nonadherence puts patients at risk for rejection, and (2) designing and pilot testing an innovative just-in-time adaptive mobile health intervention, leveraging real-time electronic pillbox data to support in-the-moment adherence at the point of medicine dosing. Both of our clinical tools have immense public health potential for improving medication adherence, reducing nonadherence-related health problems, and improving health-related quality of life among AYA kidney or liver transplant recipients and for other people taking daily medicine for chronic illnesses.

PI_NAMEs: EATON, CYD KUMIKO (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Adherence;Adolescent;Adolescent and Young Adult;American;Biological;Blood;career development;Cessation of life;Chronic Disease;Chronic Kidney Failure;Clinical;compliance behavior;Data;Databases;design;Dose;dose information;efficacious intervention;electronic adherence monitoring;electronic data;Electronics;Experimental Designs;Goals;graft failure;Health;health related quality of life;Immunosuppressive Agents;improved;indexing;Ingestion;innovation;instrument;Intervention;intervention effect;Investigation;Kidney Transplantation;Knowledge;Link;liver transplantation;Measures;medication compliance;medication nonadherence;Medicine;Methodology;Methods;mHealth;mhealth interventions;Monitor;novel;organ transplant rejection;Patients;Persons;Pharmaceutical Preparations;Phase;pilot test;Population;post intervention;Provider;Public Health;Qualitative Methods;Quality of life;Randomized;randomized trial;Reporting;Research;research and development;Research Methodology;Research Personnel;Risk;Signal Transduction;Societies;Tacrolimus;Technology;therapy design;Time;tool;Training;Training Activity;Transplant Recipients;Transplantation;uptake;young adult

PROJECT_TITLE: Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Amyotrophic Lateral Sclerosis (ALS) is a uniformly fatal disease that is closely associated with the accumulation of insoluble, potentially toxic protein aggregates within motor neurons. The goal of this work is to understand how the enzymes within lysosomes - "the recycling and disposal compartments of the cell" – are able to clear out these old proteins and how impairments within this organelle may contribute to motor neuron degeneration. This understanding could promote the development of rational therapeutics aimed at stabilizing or reversing lysosomal dysfunction in ALS to prevent motor neuron death and preserve motor function.

PI_NAMEs: SAMPOGNARO, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: age related changes;Alkalinization;Amyotrophic Lateral Sclerosis;Area;Autophagocytosis;Basic Science;biological adaptation to stress;Biological Assay;career;Cathepsins;Cathepsins B;Cell Compartmentation;Cell Physiology;Cell Survival;Cells;Clinical;Clinical Trials;Complex;Critical Pathways;Data;design;Development;Disease;Enzymes;experience;Faculty;Fellowship;Foundations;Functional disorder;Funding;gain of function;Goals;Half-Life;Homeostasis;Human;Impairment;In Vitro;Incubated;Induced pluripotent stem cell derived neurons;Investigation;K-Series Research Career Programs;knock-down;Knowledge;Knowledge acquisition;loss of function;Lysosomes;Mass Spectrum Analysis;Measures;medical schools;Membrane;Mentors;Mentorship;Methods;Modeling;Morphology;Motor;motor deficit;motor neuron degeneration;Motor Neurons;mutant;Mutation;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neurology;neuron loss;Neurons;neuropathology;novel;novel therapeutics;Organelles;overexpression;Pathogenesis;Pathogenicity;Pattern;Peptide Hydrolases;Phase;Pilot Projects;preservation;prevent;Process;protein aggregation;protein TDP-43;Proteins;purge;Recycling;Research;Research Personnel;Residencies;Resistance;Running;Scientist;Site;skills;sobriety;Solid;TDP-43 aggregation;Testing;Therapeutic;Time;Training;undergraduate student;Work

PROJECT_TITLE: TDP43 Degradation by the Lysosomal Proteases in Amyotrophic Lateral Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE This proposal will characterize non-tumor cell-autonomous mechanisms of acquired resistance to KRASG12C inhibitors in KRASG12C-mutant NSCLC using immune-competent animal models and clinical specimens and will evaluate the anti-tumor efficacy and immune-modulatory effects of combined KRASG12C and STAT3 inhibition.

PI_NAMEs: SKOULIDIS, FERDINANDOS  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acute;Animal Model;Architecture;Autopsy;biobank;Bioinformatics;Biology;Biometry;Biopsy;Bypass;Cancer Center;Cancer Patient;Cells;Cessation of life;Clinical;clinical development;clinical efficacy;clinically significant;Data;Dependence;Development;DNA Sequence Alteration;Extinction;Failure;Genetic Engineering;Genomics;Immune;Immunobiology;Immunocompetent;Immunogenomics;Immunology procedure;improved;In Vitro;individual response;inhibitor;inhibitor therapy;insight;KRAS2 gene;Malignant Neoplasms;MAP Kinase Gene;Mediator;Medical Oncology;Modeling;Molecular;molecular pathology;mouse model;Mus;mutant;Mutation;neoplastic cell;non-genetic;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;objective response rate;Oncogenic;Oncoproteins;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phosphorylation;Pre-Clinical Model;prevent;Property;Publications;Radiology Specialty;Refractory;Reporting;Resistance;resistance mechanism;Resolution;response;Role;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;small molecule;Specimen;standard of care;STAT3 gene;STK11 gene;synergism;targeted cancer therapy;Therapeutic;therapeutic target;Time;TP53 gene;tumor;Tumor Escape;tumor microenvironment;Tumor Suppressor Genes;Tyrosine;Work

PROJECT_TITLE: Dissecting and targeting tumor-TME crosstalk to forestall acquired KRASG12C inhibitor resistance in NSCLC.


NIH_SPENDING_CATS: Natural Products

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Bacterial site-specific vanadium dependent haloperoxidases (VHPOs) are a unique family of halogenating enzymes that oxidize aqueous halide ions and install them in a regio- and stereospecific manner on organic substrates. This proposal merges interdisciplinary chemical, biochemical, and genomic techniques to identify novel VHPO homologs from diverse microbes, characterize their roles in secondary metabolism and chemical ecology, and define the structural determinants of halide and organic substrate specificity. By expanding the characterized VHPO repertoire, we will provide new biosynthetic tools for the construction of biomedically relevant small molecules and biocatalytic alternatives to conventional organic chemistry halogenation strategies.

PI_NAMEs: MCKINNIE, SHAUN MITCHELL KIRK (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Identification, characterization, and application of bacterial site-specific vanadium-dependent haloperoxidase enzymes


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Researchers-in-training in biomedical fields, particularly those from underrepresented groups, contend with a number of barriers to their career success. In the proposed project, we plan to address the Triple Threat to trainees’ career success (impostor phenomenon, fixed mindset, and perceived discrimination) by developing and testing dual interventions—one for trainees and one for their mentors—that directly target and mitigate these threats. These dual interventions, which will not only address trainees’ coping skills but will also foster environmental change via their mentors and training program directors also trained to deliver the interventions, are designed to be scalable and sustainable over time, with the goal of increasing retention of all underrepresented groups in the biomedical research pipeline.

PI_NAMEs: CHANG, SHINE  (contact);COKLEY, KEVIN O

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academic achievement;Achievement;active control group;Address;African American population;Alaska Native;American Indians;Anxiety;Area;Awareness;Behavior;Behavioral;Belief;Biomedical Research;Black American;career;Career Choice;Categories;Color;Competence;Complementary therapies;coping;Coping Skills;Country;Demographic Factors;demographics;design;Development;disadvantaged background;disadvantaged student;doctoral student;educational atmosphere;Educational process of instructing;Educational workshop;empowerment;Environment;environmental change;Expectancy;expectation;experience;Feeling;Fostering;Fright;Funding;Goals;Grant;Growth;Health Sciences;Hispanic Populations;Hour;improved;innovation;Institution;Intelligence;interest;Intervention;Latino Population;Lead;Learning;Link;Measures;Mentors;Mentorship;Minority Groups;minority trainee;Modeling;Motivation;multilevel analysis;National Institute of General Medical Sciences;Native Hawaiian or Other Pacific Islander;Outcome;perceived discrimination;post intervention;Postdoctoral Fellow;psychosocial;Qualifying;Randomized;recruit;Reporting;Research;Research Design;Research Personnel;Research Training;Resources;Science;Scientist;Self Efficacy;Shapes;Site;skills;Student Persistence;student retention;Students;study population;success;Testing;Time;Time Management;tool;Training;Training Programs;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Overcoming the triple threat to diversity in the health science workforce: empowering the next gen.


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Cancer immunotherapies represent a powerful therapeutic paradigm because they are applicable to a wide variety of tumors and can produce durable clinical responses; however, only a fraction of patients experience clinical benefit from current immunotherapies, and as such there is an urgent need to develop new therapies. Our studies will focus on the immune cells underlying the resistance to current immunotherapies. Uncovering novel aspects of the immune system is crucial not just for better understanding the biology of the immune response to tumor, but also for designing the next generation therapeutics.

PI_NAMEs: MOR, ADAM  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acceleration;Address;Adverse event;Algorithmic Analysis;anti-PD-1;anti-tumor immune response;Antibodies;Arthritis;Biochemical;Biology;Blocking Antibodies;cancer cell;cancer immunotherapy;Cell Physiology;Cells;checkpoint therapy;Clinical;Clinical Trials;Complex;cytokine;Cytoplasmic Tail;Data;design;Enzymes;Event;experience;experimental study;Failure;Future;Genetic;Goals;Grant;Human;imaging approach;Immune;immune checkpoint blockade;Immune response;Immune system;immune-related adverse events;Immunotherapy;in silico;In Vitro;in vivo;Inflammatory;Inflammatory Response;innovation;Intervention;kinase inhibitor;Knockout Mice;Ligand Binding;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;MAP3K7 gene;Mass Spectrum Analysis;Mediating;Methods;Modeling;Molecular;Mus;neoplastic cell;new technology;novel;novel therapeutics;Pathway interactions;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Population;preclinical development;predicting response;prediction algorithm;Prognosis;programmed cell death protein 1;Protein Binding Domain;PTPN11 gene;Public Health;Publications;Publishing;receptor;Renal Carcinoma;Resistance;response;Role;Sequence Analysis;Signal Pathway;Signal Transduction;Structure;success;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Toxic effect;tumor;tumor growth;tumor progression;Work

PROJECT_TITLE: Novel mechanisms regulating PD-1 signaling and function

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Genetic mutations underlie cystic fibrosis (CF) and other respiratory lung diseases that are global public health burdens. This study seeks to use a gene editing technique to correct a mutation causing CF and to investigate the role of understudied CFTR mutations in the development and progression of lung disease. Findings from this work will inform the diagnosis and treatment of genetic lung diseases.

PI_NAMEs: JIANG, TINGTING  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adenine;Affect;airway epithelium;Asthma;base;base editing;base editor;Biology;bronchial epithelium;C57BL/6 Mouse;career development;Cause of Death;Cell Line;Cell model;Cell Physiology;Cells;Chronic Obstructive Pulmonary Disease;Classification;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cytidine;Data;delivery vehicle;Dependovirus;design;Development;Diagnosis;Disease;DNA;DNA delivery;DNA Double Strand Break;DNA Sequence;DNA Sequence Alteration;Engineering;Epithelial Cells;FDA approved;Fostering;functional restoration;gene correction;gene editing technology;gene therapy;gene-editing approach;Genes;Genetic;Genetic Polymorphism;Genome;genomic locus;Goals;Guide RNA;Human;Impairment;in vivo;intein;job market;Laboratories;Liver;Liver diseases;Lung;Lung Diseases;Measures;Mediating;Mentors;Methods;Monitor;mouse model;Mus;Mutation;Nonsense Mutation;Nose;novel;novel therapeutics;nuclease;Nucleotides;Organ;Pathogenesis;Pharmaceutical Preparations;Phase;Plasmids;Play;Point Mutation;Predisposition;protein expression;Proteins;Public Health;pulmonary function;Pulmonology;Regulator Genes;repaired;Reporter;Research;Research Ethics;respiratory;Risk;Role;Specificity;System;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;Therapeutic Uses;tool;trafficking;Training;transcriptome;Variant;VX-770;Work;Writing

PROJECT_TITLE: Using base editing to investigate CFTR polymorphisms in lung diseases


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The integrity and long-term function of tissues demand the presence of immune cells to preserve health. We have recently found that neutrophils, the most abundant innate immune cell in the organism, infiltrate most organs under homeostatic conditions and tailor their molecular properties and functions for each particular organ. Under this grant we will explore the molecular programs that drive neutrophil specialization in tissues, mechanisms of action, and their relevance for vascular and barrier integrity of organs.

PI_NAMEs: HIDALGO, ANDRES  (contact)

PROJECT_TERMS: Acute;antimicrobial;Applications Grants;Autoantigens;Automobile Driving;Biology;Biomechanics;Blood Platelets;Blood Vessels;Bone Marrow;Cancer Patient;Cells;Cessation of life;Chromatin;Chronic;circadian;Circulation;Containment;Cues;cytotoxic;Data;defined contribution;density;Disease;Environment;Exhibits;Faculty;fitness;Genetic;Genetic Transcription;Goals;Grant;grasp;Health;Hematopoietic stem cells;Homeostasis;Human;Imaging Device;Immune;Immunology;Infection;Infiltration;Inflammation;Inflammatory;Innate Immune System;insight;interest;Intestines;Invaded;Knowledge;Laboratories;Letters;Leukocytes;Lung;lung injury;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mechanics;Mediator;Mesenchymal;migration;Modeling;Molecular;mouse genetics;Mus;Myeloid Cells;neutrophil;Neutrophil Infiltration;Normal tissue morphology;novel therapeutic intervention;Organ;Organ Model;Organism;Pathogenicity;Pathology;Pattern;Periodicity;Phenotype;Physiological;Physiology;precision medicine;Predisposition;preservation;Process;programs;Property;Proteome;repaired;Role;Shapes;Signal Transduction;Skin;skin wound;Source;Stromal Cell-Derived Factor 1;Structure;Testing;Textbooks;tissue repair;Tissues;tool;transcriptome;Trauma;Vascular regeneration;Work

PROJECT_TITLE: Non-canonical functions of neutrophils