ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Although rapid progress has been made in identifying hundreds of genes that influence immune- mediated diseases, the vast majority of the causal variants remain to be identified. This project takes a systematic and comprehensive approach to fine-mapping the nucleotide polymorphisms at autoimmune and infectious disease risk loci in lymphoid and myeloid cell lines. It also develops technology for assessing the effects of allelic replacements and comparing effects among individuals.

PI_NAMEs: BAO, GANG ;GIBSON, GREGORY C (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Adopted;Affect;Algorithms;Alleles;Autoimmune;Autoimmune Diseases;Bioinformatics;Biological Assay;causal variant;Cell Line;cell preparation;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;Complex;Congenital Abnormality;cost;CRISPR interference;CRISPR/Cas technology;Deletion Mutation;Disease;Disease susceptibility;Engineering;epigenomics;Evaluation;Evolution;experimental study;gang;Gene Expression;Genes;Genetic;genetic association;Genetic Polymorphism;genome editing;Genome engineering;genome wide association study;Genomics;Guide RNA;Hand;HL60;Human Genetics;Immune;Immune System Diseases;Immunologic Deficiency Syndromes;Individual;Inflammatory Bowel Diseases;insertion/deletion mutation;Knock-out;Knowledge;Laboratory Study;Lymphocyte;Lymphoid;Lymphoid Cell;Maps;Measures;Mediating;Methods;microdeletion;Minor;Molecular Diagnosis;Monitor;monocyte;Mutagenesis;Mutation;Myelogenous;Myeloid Cells;Nucleotide Mapping;Pathogenicity;Penetrance;Persons;precise genome editing;prime editing;promoter;Promoter Regions;Property;Quantitative Genetics;Quantitative Trait Loci;rare variant;Reporter;Rice;risk variant;Scanning;Series;Signal Transduction;single cell genomics;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;Surveys;T-Lymphocyte;Technology Assessment;Testing;therapeutic target;tool;trait;Transcript;transcriptome sequencing;Transfection;translational medicine;Universities;Variant

PROJECT_TITLE: Precision mapping of regulatory causal variants by expression CROPseq

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal will interrogate a novel cell population identified in the developing human lung, referred to as Fetal Airway Secretory (FAS) cells, that are marked by SCGB3A2/SFTPB/CFTR. Since nothing is known about FAS cells, and there is no analogous population in the murine lung, the overarching goal of this proposal is to use an in vitro model of FAS differentiation to describe these cells in detail, to interrogate their differentiation potential, and to determine how they are regulated, thereby providing foundational descriptive and mechanistic insights into a new cell type in the human lung.

PI_NAMEs: SPENCE, JASON  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: ASCL1 gene;Atlases;Bar Codes;Basal Cell;Biology;Cell Differentiation process;Cell Lineage;Cell surface;cell type;Cells;Conceptions;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Epithelial Cells;Epithelium;experimental study;fetal;follow-up;Gene Expression Profile;Gene Modified;Genes;genetic signature;Goals;Human;In Vitro;in vitro Model;inhibitor;insight;Lung;MADH2 gene;Mediating;Methods;Modeling;Mus;Neuroendocrine Cell;novel;Organoids;pharmacologic;Phase;Population;progenitor;Publishing;Reporting;Secretory Cell;Signal Transduction;single-cell RNA sequencing;stem cells;System;Testing;Time Series Analysis;Tissues;tool

PROJECT_TITLE: Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT HLTH/HUMAN RSCS

ORG_STATE: WV

PHR: West Virginia Pregnancy Risk Assessment Monitoring System  (WV PRAMS) Narrative This application is seeking funding for the West Virginia PRAMS Project which is house within the West Virginia Office of Maternal, Child and Family Health in the Bureau for Public Health under the Department of Health and Human Resources. The WV PRAMS Project has been a long-standing component of the Office of Maternal, Child and Family Health and it's continued presence is integral in the planning, evaluation and intervention methods across maternal and child health programs in the Office.

PI_NAMEs: STOVER, MONICA J (contact)

PROJECT_TITLE: DP21-001 WV Pregnancy Risk Assessment Monitoring System - PRAMS


ORG_CITY: SANTA FE

ORG_NAME: NEW MEXICO STATE DEPARTMENT OF HEALTH

ORG_STATE: NM

PHR: Office of the Vice President for Research INSTITUTIONAL REVIEW BOARD (IRB) Dr. Merranda Romero Marin, Chair MSC 3 RES New Mexico State University P.O. Box 3001 Las Cruces, NM 88003-8001 Phone: 575-646-7177 Fax: 575-646-2480 Email: ovpr@nmsu.edu DATE: July 11, 2020 FROM: The Office of Research Integrity and Compliance TO: Eirian Coronado  Research Assistant: Carol Hust  Research Assistant: Glenda Hubbard  Research Assistant: Dorin Sisneros  Research Assistant: Rosie Lucero  Research Assistant: May Montoya  Co PI:Del Yazzie  Department Head:Michael Landen SUBJECT: Decision Memo for Application #18661 Project Title: Application Type: Review Type: Approval Period: Parent Application: Review Category: New Mexico Pregnancy Risk Assessment Monitoring System Status Report Expedited July 10th, 2020- July 9th, 2021 7 The NMSU Institutional Review Board Chair, Dr. Merranda Romero Marin, has reviewed and approved the above application for the conduct of research involving human subjects. The application was reviewed in accordance with the review process outlined in 45 CFR 46.110(b)(2) - Category 7 (Status Report 1). The research must be conducted according to the proposal/protocol that was approved by the IRB. Any changes in the research, instruments, or the consent document(s) must be submitted to the IRB prior to implementation. Additionally, any unexpected hazards or adverse events involving risk to the subjects or others must be reported immediately to the IRB, using the appropriate form, within the time frame specified in the NMSU Principles and Procedures for the Conduct of Research Involving Human Subjects. Note: Data collected during a period of lapsed approval is unapproved research and can never be reported or published as research data. Please note that the IRB approval is valid for one (1) year. Pursuant to NMSU institutional policy, the IRB must review and approve all research protocols involving human subjects at intervals appropriate to the degree of risk, but no less than once per year. Therefore, in order to continue your project after the above approved period you must submit an annual Status Report prior to the above referenced approval period. .

PI_NAMEs: CORONADO, EIRIAN  (contact)

PROJECT_TITLE: DP21-001 Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: PIERRE

ORG_NAME: SOUTH DAKOTA STATE DEPT OF HEALTH

ORG_STATE: SD

PHR: PROJECT NARRATIVE  South Dakota has one of the highest infant and postneonatal mortality rates in the United States, with large racial disparities. The information obtained from participation in the CDC PRAMS as a Core Surveillance state will provide important information on maternal attitudes and behaviors around the time of pregnancy and help guide maternal and child health programs in the state. Previous participation in the CDC PRAMS has led to significant work and outreach with maternal child health stakeholders.

PI_NAMEs: STRASSER, KATELYN  (contact)

PROJECT_TITLE: DP21-001 Component A South Dakota PRAMS


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA STATE DEPT OF HEALTH

ORG_STATE: PA

PHR: R&R Other Project Information  Pennsylvania PRAMS Project Component A: Core Surveillance Project Narrative: The Pennsylvania Pregnancy Risk Assessment Monitoring System (PA PRAMS) project collects information on selected maternal behaviors and experiences occurring before, during, and after pregnancy from a monthly random sample of residents with a live birth. The project’s mission is to promote the collection, analysis, and dissemination of population-based data of high scientific quality and to support the use of data to develop policies and programs in order to reduce maternal and infant morbidity and mortality. It is anticipated implementation of the PA PRAMS project over the next five-year period will continue to result in timely, high quality data to monitor prevalence of, and inequities in, maternal health behaviors and experiences.

PI_NAMEs: MCCARTY, ERIN EMILY (contact)

PROJECT_TITLE: DP21-001 The Pennsylvania Pregnancy Risk Assessment Monitoring System (PA PRAMS) Project


ORG_CITY: Trenton

ORG_NAME: NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS

ORG_STATE: NJ

PHR: PRAMS Project Narrative New Jersey PRAMS is a surveillance system designed to collect data that contributes to the improved health of New Jersey mothers and infants. Information from PRAMS is used to help plan and evaluate health programs such as those focusing on improving access and early prenatal care, reducing smoking during pregnancy and encouraging safe sleep practices. PRAMS provides data that can be used to inform decision making.

PI_NAMEs: COOLEY, SHARON SMITH (contact)

PROJECT_TITLE: DP21-001 New Jersey Pregnancy Risk Assessment Monitoring System (PRAMS) - Component A: Core Surveillance


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Dissemination and Implementation Research;Heart Disease;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Implementation science has the potential to transform the delivery of care and improve health equity for heart and lung diseases in real-world settings. This T32 program will provide a diverse group of trainees with the structured mentorship, education, and hands-on training needed to translate the strong evidence base in the prevention and management of heart and lung diseases into effective practice in diverse populations. Unique strengths of the program include 1) a focus on the intersection of implementation science and health equity; 2) exceptional opportunities in didactic and experiential learning; and 3) team-based research mentorship.

PI_NAMEs: CATTAMANCHI, ADITHYA ;THAKUR, NEETA  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Equity;Heart Diseases;implementation science;Lung Diseases;Research;Training Programs

PROJECT_TITLE: Partnerships for Research in Implementation Science for Equity in Heart and Lung diseases training program (PRISE-HL T32)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed research aims to understand the molecular basis of transcription on unnatural base pairs. This knowledge will provide a framework for developing next generation of unnatural base pairs. This will pave the way for the development of novel nucleic acid and protein therapeutics for diagnosis and treatment of human diseases in the future, which is highly relevant to public health and NIH’s mission.

PI_NAMEs: WANG, DONG  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Active Sites;Adenine;Amino Acids;Bacteriophage T7;Base Pairing;Binding;Biochemical;Biochemistry;Biology;Biophysics;Chemicals;Chemistry;Complex;Computational Biology;Cryoelectron Microscopy;Cytosine;Data;design;Development;Diagnosis;DNA;DNA-Directed RNA Polymerase;Enzymes;Escherichia coli;Eukaryota;Family;Foundations;functional group;Future;Genetic;genetic information;Genetic Transcription;Goals;Guanine;human disease;Hydrogen Bonding;Hydrophobicity;in vivo;Information Storage;insight;Kinetics;Knowledge;Label;Life;Methods;Mission;Molecular;next generation;novel;novel therapeutics;nucleic acid-based therapeutics;Nucleic Acids;Nucleotides;Organism;Outcome;Planet Earth;Polymerase;Prokaryotic Cells;Proteins;Public Health;Reaction;Research;Retrieval;RNA;RNA Polymerase II;Series;Shapes;structural biology;Structure;synthetic biology;synthetic nucleotide;T7 RNA polymerase;Testing;therapeutic protein;Thymine;tool;United States National Institutes of Health;Uracil;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Recognition of Synthetic Unnatural Base Pairs by RNA Polymerase

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project narrative: Cancer-induced cachexia, or cancer cachexia, is a complex metabolic syndrome that significantly increases the morbidity and mortality of cancer patients. However, understanding of the underlying mechanism of cancer cachexia is limited and hence there is no standardized assessment or established treatment. The current project is designed to evaluate whether cancer-released circulating Hsp70 and Hsp90 are biomarkers and therapeutic targets of human cancer cachexia based on previous findings in mouse models of cancer cachexia.

PI_NAMEs: JAFRI, SYED  H;LI, YI-PING  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Animal Model;Biological Markers;Cachexia;Cancer Cachexia;cancer cell;Cancer Etiology;Cancer Intervention;Cancer Patient;cancer therapy;cancer type;Catabolism;Cessation of life;Clinical;Clinical Research;Complex;cytokine;Data;Degradation Pathway;design;Development;Diagnosis;Diagnosis Clinical Trials;Disease;driving force;Etiology;Event;extracellular;extracellular vesicles;Florida;gene therapy;Human;Implant;improved;In Vitro;in vivo;Inflammatory;inhibitor;Interleukin-6;Investigational Therapies;knock-down;Longitudinal Studies;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediator;member;Metabolic syndrome;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;Muscular Atrophy;Natural History;neoplastic cell;neutralizing antibody;Newly Diagnosed;Omeprazole;Outcome;pancreatic cancer cells;pancreatic PDX models;Pathologic;patient derived xenograft model;Patients;pharmacologic;preservation;protein degradation;recruit;release factor;Research Personnel;response;Serum;Standardization;success;systemic inflammatory response;Testing;therapeutic target;Time;TLR4 gene;TNF gene;tumor;Universities;vesicular release

PROJECT_TITLE: Identification of key tumor cell-released factors that induce cachexia

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Natural Products

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Methane gas is a major contributor to climate change, which represents a significant threat to human health. This research program focuses on the chemistry and biology of methanotrophs, methane-consuming bacteria that have the potential to mitigate methane emissions in an environmentally-friendly and productive fashion. In addition, methanotrophs produce copper-binding natural products with promising applications as metal-chelating therapeutics.

PI_NAMEs: ROSENZWEIG, AMY C. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Active Sites;Address;Ammonia;Anabolism;Bacteria;Binding;Biochemical;Bioinorganic Chemistry;Biology;Biophysics;Biosynthetic Proteins;chelation;Chemicals;Chemistry;climate change;Consumption;Copper;Disease;Environment;Enzymes;Friends;Gases;genetic approach;genetic manipulation;Global Warming;greenhouse gases;Health;Hepatolenticular Degeneration;Homeostasis;Homologous Gene;Human;in vivo;insight;Investigation;Iron;Lipids;Location;Membrane;Metabolic Pathway;Metabolism;metalloenzyme;Metals;Methane;Methane hydroxylase;Methanol;Microbe;Mixed Function Oxygenases;Molecular;Multienzyme Complexes;Natural Products;Nature;Operon;oxidation;Particulate;Process;Productivity;programs;Proteins;Reducing Agents;Research;Research Project Summaries;Ribosomes;Site;spectroscopic data;Structure;tailored natural product;Therapeutic;tool

PROJECT_TITLE: Metalloenzymes and metal homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Human Genome;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Hearing impairment (HI) is the most common sensory deficit in the world and occurs in 1-2 per 1000 newborns. Understanding the mechanism of hearing will greatly aid in the development of treatment strategies for HI. Identification of genes and variants that cause HI in a variety of populations is highly beneficial for understanding the mechanism of hearing, developing treatment modalities, and for diagnosis through genetic screening.

PI_NAMEs: LEAL, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Affect;Africa;African;African American population;African ancestry;Agreement;American;Animal Model;Architecture;Asia;Auditory;autosome;Benign;Bilateral;Calcium and Integrin Binding Protein 2;Cameroon;causal variant;Cellular Morphology;Child;Clinical;Cognitive;Collection;Complex;congenital hearing loss;Coniferophyta;Data;Data Analyses;Databases;Defect;Development;Diagnosis;Diagnostic;diagnostic development;Dideoxy Chain Termination DNA Sequencing;DNA;Early Diagnosis;Embryo;Emotional;Ensure;Etiology;Europe;exome;Exons;Expression Profiling;Family;Family member;Family Study;Finland;Frequencies;Funding;gene function;Generations;Genes;Genetic Heterogeneity;genetic pedigree;Genetic Predisposition to Disease;Genetic Screening;genetic variant;Genomics;Ghana;GJB2 gene;Goals;Hair Cells;Hearing;hearing impairment;Heterozygote;Human;Hungary;improved;Individual;inner ear development;innovation;Intervention;Iran;Jordan;Knowledge;Labyrinth;Language Development;loss of function;Mali;Meleagris gallopavo;member;Messenger RNA;Methods;Minority Groups;Modality;Modeling;mouse model;Mus;mutant;Mutation;Newborn Infant;next generation;next generation sequence data;next generation sequencing;Nigeria;Nigerian;novel;Pakistan;Pathogenicity;Physiology;Play;Population;Process;protein function;Proteins;Public Health;Research;Role;Sampling;segregation;Senegal;Sensory;Slave;social;South Africa;South Asian;Speech Development;Structure;Switzerland;System;Testing;Therapeutic Intervention;therapy development;tool;trait;treatment strategy;Untranslated RNA;Validation;Variant;virulence gene;whole genome;Zebrafish

PROJECT_TITLE: Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Navigation is an important aspect of our everyday lives, and one of the key brain structures involved in navigation is the retrosplenial cortex, yet we know very little about its function. The proposed research will challenge classical models of retrosplenial cortex computations that support the flexible use of both viewer- centered and world-centered (map-like) representations in remembering and navigating learned spaces. Advancing theories in the cognitive and neural bases of retrosplenial cortex contributions to learning, memory and navigation will provide insight into disease pathologies associated with insult to this brain region.

PI_NAMEs: STARRETT AMBROSE, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3-Dimensional;Accounting;adjudication;Area;Automobile Driving;base;Basic Science;Bayesian Analysis;Behavior;Behavioral Paradigm;blood oxygen level dependent;Brain;Brain region;Categories;Classification;Code;Cognition;Cognitive;cognitive process;Complex;complex data;Data;Data Collection;Data Set;Dementia;design;Detection;Diagnosis;Discrimination;Disease;Disorientation;Ego;Elements;Environment;Episodic memory;experience;experimental study;flexibility;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Human;human model;Inferior;innovation;insight;Knowledge;Learning;Literature;Location;Maps;Mediating;member;Memory;memory consolidation;Memory Loss;memory recognition;Methods;Modeling;Multivariate Analysis;Nervous System Disorder;neural;neuroimaging;non-invasive imaging;novel;novel strategies;Organism;Pathology;Persons;pre-clinical;Primates;Published Comment;Receiver Operating Characteristics;Research;Research Design;Resources;response;Retrieval;ROC Curve;Rodent;Sensory;Signal Transduction;spatial memory;Stimulus;Stream;Stroke;Structure;success;Techniques;Testing;theories;Training;Translating;Translations;Update;Variant;virtual reality;virtual reality environment;way finding;young adult

PROJECT_TITLE: Challenging Classical Theories in Spatial Cognition: Contrasting Translator and Comparator Models of Human Retrosplenial Function

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE There is currently no therapy that can prevent the development of epilepsy after brain trauma. Here we propose to test the efficacy of a novel compound, and determine its efficacy and tolerability in an animal model of posttraumatic epilepsy, in a setting that resembles the clinical practice of care of people with severe traumatic brain injury. We also aim to identify and validate novel biomarkers that can predict who will develop epilepsy and who may respond to a treatment that can prevent epilepsy, in hope that this may accelerate and optimize future efforts to develop new antiepileptogenic therapies.

PI_NAMEs: AGOSTON, DENES V.;COLES, LISA D;DUNCAN, DOMINIQUE ;GALANOPOULOU, ARISTEA S (contact);MAZARATI, ANDREY M;O'BRIEN, TERENCE JOHN;STABA, RICHARD

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;acquired epilepsy;Acute;Advisory Committees;Advocate;Anatomy;Animal Model;Anticonvulsants;Antiepileptogenic;Autophagocytosis;Axon;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker selection;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Brain Pathology;Calcium-Binding Proteins;California;candidate marker;Caring;Cell Death;Cessation of life;Classification;Clinical;clinical practice;Collaborations;college;Corpus Callosum;Data;Deposition;design;Development;Discriminant Analysis;Disease;Double-Blind Method;early detection biomarkers;Early Post-Traumatic Seizures;Early treatment;efficacy testing;Electroencephalography;Epilepsy;Epileptogenesis;experience;External Capsule;fluid percussion injury;Free Radicals;functional outcomes;Funding;Future;Glial Fibrillary Acidic Protein;Guidelines;Health Services;Hemorrhage;High Frequency Oscillation;high standard;histological stains;HMGB1 gene;Image;improved;in vivo;Inflammatory;Injury;Interferon Type II;Interleukin-1 beta;International;Intervention;Investigation;Iron;Iron Chelation;Isoenzymes;Laboratories;Lateral;Learning;Levetiracetam;Link;Machine Learning;Magnetic Resonance Imaging;Medicine;Memory;Metabolic;Minnesota;Modeling;Modification;Molecular;Monitor;Motor;multimodality;National Institute of Neurological Disorders and Stroke;Neuroglia;neuroimaging;Neurons;novel;novel marker;Oxidative Stress;Pathologic;Pathology;Patients;Peripheral;Persons;pharmacokinetic model;Physiological;Plasma;Populations at Risk;Post-Traumatic Epilepsy;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Predictive Value;prevent;primary endpoint;Process;prophylactic;protein biomarkers;Randomized;Rattus;Recovery of Function;Research;Risk;Risk Factors;Seizures;Site;standard of care;synergism;tau Proteins;tau-1;Testing;Therapeutic;Time;Tissues;Translational Research;Traumatic Brain Injury;treatment response;ubiquitin C-terminal hydrolase;Universities;University Health Services;Visuospatial

PROJECT_TITLE: Translational Platform for Epilepsy Therapy and Biomarker Discovery


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Sleep Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The progression of Alzheimer's disease (AD) and related dementias (ADRD) leads to abnormal sleep/activity patterns, associated wandering, and disruptive behaviors in AD/ADRD patients, causing tremendous stress and fatigue to family caregivers that can lead to the patients' institutional placement. Our current R01 shows that both short- and long-term light exposures result in significant improvement in sleep, behavior, and mood, but it remains unknown how the light dose (amount and duration) affects circadian response in AD/ADRD patients. Addressing this dose–response issue will further contribute to the scientific understanding of AD/ADRD while providing a translational component for the development of new lighting products designed to promote sleep and reduce behavioral disturbances in AD/ADRD patients.

PI_NAMEs: FIGUEIRO, MARIANA GROSS (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Address;Affect;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Assisted Living Facilities;awake;Behavior;Behavioral;Calibration;Caregivers;circadian;Circadian Rhythms;Cognition;comparison control;Controlled Environment;Darkness;Data;Data Collection;Dementia;design;Development;Devices;Dose;effective therapy;Enrollment;experience;Exposure to;Family;Family Caregiver;Fatigue;Grant;Home;Home environment;improved;improvement on sleep;Institution;instrument;Intervention;intervention effect;Light;Lighting;Long-Term Care;loved ones;Measurement;Measures;Memory;memory care;Mental Depression;Methodology;Moods;Multi-Institutional Clinical Trial;Nonpharmacologic Therapy;Nursing Homes;older adult;Outcome;Outcome Measure;Outcome Study;Participant;Patients;Pattern;Persons;Phase;Phototherapy;Physicians;Placebo Control;placebo controlled study;Placebos;Population;portability;Precipitating Factors;Protocols documentation;Quality of life;Random Allocation;Randomized;Records;Research Personnel;response;Rest;Sleep;sleep abnormalities;Sleep disturbances;sleep onset;sleep quality;Societies;Stimulus;Stress;study population;Study Section;Symptoms;System;Technology;Testing;Visual;Wakefulness

PROJECT_TITLE: Methodology Issues in a Tailored Light Treatment for Persons with Dementia

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Following consumption of a meal, pancreatic beta-cells secrete insulin, a hormone that promotes the uptake and storage of carbohydrates and other nutrients in skeletal muscle while simultaneously repressing glucose efflux from the liver. Diabetes mellitus results from insulin availability that is insufficient to meet tissue needs, and both the type 1 and type 2 forms of the disease are associated with decreased beta-cell mass and insulin production. Herein we propose to test the hypothesis that a family of nutritional byproducts termed ceramides contribute to this decline in beta cell function that drives both forms of the disease.

PI_NAMEs: HOLLAND, WILLIAM L;SUMMERS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adipose tissue;Anabolism;Animal Model;Apoptosis;Apoptotic;aqueous;Autoimmune;Beta Cell;biological adaptation to stress;Biological Assay;Biological Markers;Biotechnology;Blood Glucose;Carbohydrates;Cell Physiology;cell regeneration;Cell Survival;Cells;Ceramides;Cessation of life;Consumption;cytokine;Cytoprotection;Data;detection of nutrient;Detergents;Development;Diabetes Mellitus;diabetic;dihydroceramide;dihydroceramide desaturase;Disease;drug candidate;Drug Kinetics;efficacy testing;Enzymes;Failure;Family;Fatty Acids;Genes;Glucose;Growth;Hormones;Human;Hyperglycemia;Immunologics;impaired glucose tolerance;Impairment;improved;in vivo;Inbred NOD Mice;Induction of Apoptosis;Inflammation;Inflammatory;inhibitor;Insulin;insulin secretion;Intestinal permeability;islet;islet xenograft;Islets of Langerhans;Isotopes;Link;Lipids;Liver;Macronutrients Nutrition;Membrane;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;mouse model;Mus;Muscle;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nutrient;Nutritional;Organism;overexpression;Pancreas;Pathway interactions;peptide hormone;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phenotype;pi bond;Population;preservation;prevent;Production;Property;Rattus;Repression;Rodent;Rodent Model;Role;Safety;saturated fat;Saturated Fatty Acids;Science;Signal Transduction;single cell sequencing;Skeletal Muscle;small molecule inhibitor;Solubility;Sphingolipids;Stress;Structure of beta Cell of islet;Testing;theories;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;tool;Transgenic Mice;Treatment Efficacy;type I and type II diabetes;uptake;Work

PROJECT_TITLE: The Role of Ceramides in the Pancreatic Beta Cell


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE This proposal will encourage individuals from diverse backgrounds, especially those that are underrepresented in biomedical science, to pursue careers in biomedical research. Since its inception in 2009, the Michigan Postbaccalaureate Research Education Program (UM PREP) has prepared over 100 scholars to successfully compete for admission to graduate programs across a wide range of disciplines, including, but not limited to Biochemistry, Bioinformatics, Biomedical Engineering, Biophysics, Cancer Biology, Cell Biology, Developmental Biology, Genetics, Immunology, Microbiology, Neuroscience, Pathology, Pharmacology, Physiology, and Neuroscience. In this renewal application, we will continue to enhance our efforts to prepare UM PREP trainees for success in graduate programs so that they can continue to make outstanding contributions as part of a diverse scientific workforce.

PI_NAMEs: ALLEN, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Admission activity;Arts;Award;Behavioral Sciences;Biochemistry;Bioinformatics;Biology;Biomedical Engineering;Biomedical Research;Biometry;Biophysics;Cancer Biology;career;Cellular biology;Chemicals;Chemistry;Chicago;cohort;college;Country;Critical Thinking;Dedications;design;Development;Developmental Biology;Discipline;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational Activities;Educational workshop;Engineering;Enrollment;Epidemiology;Exposure to;Faculty;faculty mentor;Fellowship;Foundations;Funding;Genetic;Genomics;Goals;Graduate Degree;graduate school;Grant;Health Sciences;Human;Immunology;Individual;Institution;Kinesiology;Literature;Maintenance;materials science;matriculation;Mechanics;medical schools;Medicine;meetings;Mental Health;Mentors;Methods;Michigan;Microbiology;Molecular Biology;Movement;Neurosciences;Oral;Oral health;Participant;Pathology;Pharmaceutical Chemistry;Pharmacologic Substance;Pharmacology;Pharmacy Schools;Physiology;Population;Positioning Attribute;Postbaccalaureate;pre-doctoral;Preparation;Productivity;programs;Psychology;Public Health;Public Health Schools;Publications;recruit;Research;Research Training;Resources;responsible research conduct;retention rate;Scholars Program;School Dentistry;Schools;Science;Sensory;skills;Students;success;Talents;tenure track;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Washington;webinar;Well in self;Woman;Work

PROJECT_TITLE: University of Michigan Postbaccalaureate Research Education Program (UM PREP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Contraception/Reproduction;Digestive Diseases;Infertility;Inflammatory Bowel Disease

ORG_CITY: DEEP RIVER

ORG_NAME: THETIS PHARMACEUTICALS, LLC

ORG_STATE: CT

PHR: NARRATIVE Ulcerative colitis (UC) is a growing global health problem affecting approximately 1.5 million people in the US alone, and is a growing and significant unmet medical concern. Oral agents that are safe and effective for the induction and maintenance of UC remission are in dire need as additional treatment options, and to limit the use of drugs with potentially severe side effects. Thetis plans to investigate TP-317, an innovative and potential first in-class therapeutic agent, as an oral therapy for the induction and maintenance of remission of intestinal inflammation and symptoms in UC patients. .

PI_NAMEs: PARKINSON, JOHN  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Adverse effects;Affect;Biological Products;Canis familiaris;Chronic;Clinic;Clinical;clinical development;Cohort Studies;Colitis;Colon;cost;Crohn's disease;Development;Disease remission;Dosage Forms;Dose;Drug Kinetics;Drug usage;Embryo;Embryonic and Fetal Development;Enrollment;Evaluation;Female of child bearing age;Fertility;Fertilization;Formulation;Foundations;Funding;Gastrointestinal tract structure;Germ Cells;global health;Goals;good laboratory practice;Grant;Growth;gut inflammation;healthy volunteer;Homeostasis;Human;Immune;Immunomodulators;Immunosuppressive Agents;implantation;Infection;Inflammation;innovation;Interleukin-12;Intestines;Investigational Drugs;Janus kinase;Legal patent;lipid mediator;Maintenance;Maintenance Therapy;Malignant Neoplasms;mating behavior;Medical;Mesalamine;Molecular;Oral;Oral Administration;Organ;Oryctolagus cuniculus;parenteral administration;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;phase 1 study;phase I trial;Phase II Clinical Trials;Play;Pre-implantation Embryo Development;pre-Investigational New Drug meeting;pregnant;preservation;Process;programs;Rattus;Rectum;Recurrent disease;reproductive;reproductive function;Resolution;Risk;Role;Safety;safety study;scale up;side effect;Small Business Innovation Research Grant;Sperm Maturation;sphingosine 1-phosphate;Sprague-Dawley Rats;Symptoms;Therapeutic Agents;tissue repair;TNF gene;Toxic effect;Toxicokinetics;Toxicology;Trust;Ulcer;Ulcerative Colitis;United States;United States National Institutes of Health

PROJECT_TITLE: Development of TP-317 in Ulcerative Colitis


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Kidney Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Diabetes accounts for approximately 45% of prevalent ESRD cases in the United States, therefore new interventions to prevent or decelerate development of kidney failure are critical in order to improve the health of patients with diabetes who comprise a large sector of the US population. This study will advance our knowledge regarding the etiology of diabetic kidney complications evaluating specific components of systemic (KRIS) and local, kidney inflammation (Complement). These advances offer long-term potential for the development of new therapies that will ultimately improve clinical outcomes of patients with diabetes.

PI_NAMEs: NIEWCZAS, MONIKA ANNA (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Address;aptamer;biobank;Biological Markers;CCL2 gene;Characteristics;Chronic;Clinical;Clinical Trials;cohort;Cohort Studies;Complement;complement pathway;complement system;Complex;Data;Data Reporting;Deceleration;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease Progression;disorder risk;drug development;End stage renal failure;Ethnic Origin;Etiology;Evaluation;follow-up;Goals;Health;Histology;Immunoglobulin G;improved;indexing;Inflammation;Inflammatory;Injury to Kidney;innovation;insight;Intervention;Kidney;Kidney Failure;Knowledge;Machine Learning;Measurement;Mediating;Mediation;Medicine;member;Nature;nephrogenesis;Nested Case-Control Study;non-diabetic;novel;novel therapeutics;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Pilot Projects;Population;prevent;primary outcome;Process;Progressive Disease;prospective;Proteins;Proteome;Proteomics;Public Health;Publishing;random forest;Renal function;Resolution;Risk;Role;Severity of illness;Signaling Protein;Source;stem;study population;systemic inflammatory response;Technology;Tissue Banks;Tissues;tool;transcriptomics;Tubular formation;Tumor Necrosis Factor Receptor;United States;urinary

PROJECT_TITLE: Understanding the role of the Complement Proteome in progressive Diabetic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Formation of the myelin sheath that surrounds the auditory nerve in the cochlea is essential for normal hearing. A better understanding of the molecules and cell types that are required for the development of myelin and the repair of damaged myelin will lead to new therapies to treat and prevent hearing loss in humans.

PI_NAMEs: CORFAS, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Ablation;Acoustic Nerve;Action Potentials;Acute;Address;Adolescent;Adult;Affect;Age;Animals;Auditory;auditory deprivation;auditory neuropathy;Auditory system;Auditory Threshold;Axon;Behavior;cell injury;cell type;Cells;Central Nervous System;Cessation of life;Cochlea;Cochlear Nerve;Data;Defect;Demyelinations;Development;Diphtheria Toxin;Disease;Distal;Ear;Electron Microscopy;Electrophysiology (science);Environment;experience;experimental study;Fiber;Functional disorder;Genes;Genetic;Genetic Recombination;Hair Cells;Hearing;hearing impairment;Hearing Tests;Human;in vivo;Injections;insight;Knockout Mice;Knowledge;Labyrinth;Maintenance;Measures;mechanotransduction;Mediating;Messenger RNA;Modality;Modeling;Molecular;Morphology;Motor;mouse model;Mus;mutant;Mutant Strains Mice;Myelin;Myelin Basic Proteins;Myelin Sheath;myelination;Neonatal;Nerve;Nerve Fibers;neural;Neuroglia;Neurons;normal hearing;novel therapeutics;NRG1 gene;Oligodendroglia;Peripheral;Peripheral Nerves;Peripheral Nervous System;postnatal;postnatal development;prevent hearing loss;Process;Publishing;Ranvier's Nodes;remyelination;repaired;Resolution;Role;Schwann Cells;Sensory;Signal Transduction;SLC17A8 gene;sound;Speech;spiral ganglion;synaptic function;Synaptic Transmission;Tamoxifen;Techniques;Testing;Time;tool;Transgenes;Transgenic Mice;transmission process

PROJECT_TITLE: The Roles of Neuronal Activity in Peripheral Nerve Myelination


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative The hippocampus can represent memories, present experiences, and imagined futures, but it remains unclear if subregions of the hippocampus are separately engaged in these representations. The proposed research will specifically test if two subregions are better understood as distinct or coupled networks based on the patterning of spatial representations in each and the correlation structure of the combined network. By uncovering the functional heterogeneity across hippocampal subregions, we will advance our fundamental knowledge of how memories and prospective futures are coordinated with our present experiences.

PI_NAMEs: NEVERS, RHINO  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Examining simultaneous encoding of local and remote space across distinct hippocampal subnetworks


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative The primary objective of this multicenter prospective cohort trial is to effectively evaluate the test performance of novel molecular techniques for the diagnose of congenital syphilis (CS). It is hypothesized that contemporary molecular platforms will result in more sensitive, specific and timely diagnosis of congenital infection with Treponema pallidum compared to the current CDC diagnostic standards. In addition, we plan to leverage the resulting clinical cohort to more accurately define adverse neurodevelopmental outcomes associated with CS.

PI_NAMEs: STAFFORD, IRENE A. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Age Months;Algorithms;Biological Assay;Birth;Blinded;Blood;Categories;Centers for Disease Control and Prevention (U.S.);Central Nervous System;Cerebrospinal Fluid;Child;Childhood;Clinical;co-infection;cohort;Collaborations;congenital infection;Congenital Syphilis;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic tests;Disease;early childhood;Early Intervention;Enrollment;Evaluation;Exclusion;Exposure to;follow-up;Gestational Age;Globus Pallidus;Guidelines;head-to-head comparison;healthcare burden;Hour;improved;Individual;Infant;Infection;innovation;Interdisciplinary Study;Intervention;intervention program;Laboratory Finding;Lesion;Letters;Linear Regressions;Live Birth;Mann-Whitney U Test;Methods;Modality;Modernization;Molecular;Mucous Membrane;Neonatal;neonatal infection;neonatal morbidity;neonate;neurodevelopment;Newborn Infant;novel;novel diagnostics;Nucleic Acid Amplification Tests;offspring;Outcome;Pathogen detection;Patients;performance tests;Perinatal;Physical Examination;Placenta;Policies;Polymerase Chain Reaction;Postpartum Period;Pregnancy;Prevalence;prevent;primary outcome;Probability;prospective;Prospective cohort;Public Health;Recommendation;Recording of previous events;recruit;Regression Analysis;Research;Risk;Sample Size;Science;screening;Seizures;Serodiagnoses;Serology test;sex;Sexually Transmitted Diseases;Side;Students;Swab;Symptoms;Syphilis;Syphilis Serodiagnosis;Techniques;Test Result;Testing;Time;Toddler;transcription mediated amplification;Treatment Protocols;Treponema pallidum;United States Dept. of Health and Human Services;Urine;Woman

PROJECT_TITLE: Modernizing Perinatal Syphilis Testing

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE (RELEVANCE) The availability of new blood-based biomarkers provides an opportunity to investigate the application of “A/T/N biomarker profile” in community-based, observational study, and provide endophenotypes that can be used to identify genetic research. The Washington Heights, Inwood Columbia Aging Project study is one of the few cohorts where these newly-established blood-based biomarkers (Aβ40, Aβ42, total tau, phosporylated-tau217, neurofilament light chain or NFL) and well-established neuroimaging biomarkers for AD can be used to investigate the application of “A/T/N biomarker profile” across race/ethnic groups and by age and sex.

PI_NAMEs: BRICKMAN, ADAM M;MANLY, JENNIFER JAIE;MAYEUX, RICHARD P (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Affect;African American;African American population;African Caribbean;Age;age difference;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Autopsy;base;Biological;Biological Markers;Blood;blood-based biomarker;Brain imaging;brain magnetic resonance imaging;brain volume;Caribbean Hispanic;cerebral atrophy;Cerebrospinal Fluid;Cerebrovascular Disorders;Classification;Classification Scheme;Clinical;clinical diagnosis;Cognition;Cognitive;cohort;Communities;Community Networks;Cross-Sectional Studies;Cyclotrons;Data;Data Set;Dementia;Development;Diagnosis;Disease;DNA;Early Diagnosis;Education;Elderly;endophenotype;Environment;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;exome;follow-up;Genetic;genetic analysis;genetic predictors;Genetic Predisposition to Disease;Genetic Research;genome sequencing;genome-wide;Genotype;Goals;health care availability;health disparity;Height;Hemorrhage;Image;imaging biomarker;Impaired cognition;improved;indexing;Individual;Infarction;Investigation;Life Cycle Stages;Light;longitudinal analysis;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;metabolic abnormality assessment;Mexican Americans;mild cognitive impairment;Mind;Molecular;molecular imaging;multi-ethnic;Neighborhoods;Nerve Degeneration;neurofilament;neuroimaging marker;neuropathology;Not Hispanic or Latino;Observational epidemiology;Observational Study;Occupations;Outcome;Participant;Phenotype;phenotypic data;Plasma;polygenic risk score;Population;Positron-Emission Tomography;prospective;protective factors;psychosocial;Psychosocial Factor;Quantitative Trait Loci;Race;racial population;Risk Factors;Sampling;sex;SNP array;SNP genotyping;social;social health determinants;Socioeconomic Status;tau Proteins;tau-1;Therapeutic Trials;Thick;Time;Universities;Variant;Vascular Diseases;Washington;White Matter Hyperintensity;Whole Blood

PROJECT_TITLE: Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Esophageal adenocarcinoma (EAC) is a devastating disease that has increased seven-fold in the past four decades, yet the survival rate remains poor at less than 20%. The established risk factors for EAC and its precursor lesion, Barrett’s esophagus, are highly prevalent in the VA population. Therefore, there is an urgent need to improve current strategies to prevent or treat EAC. Efforts to improve outcomes are limited by inadequate understanding of the mechanisms underlying EAC progression. This proposal aims to improve the lives of Veterans and their families through mechanistic discoveries related to EAC development, which can be leveraged to improve treatment standards for this lethal cancer.

PI_NAMEs: BLUM, ANDREW EDWARD (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Adenocarcinoma Cell;Age;arm;Award;Barrett Esophagus;Binding;Biological Availability;biomarker development;Biomedical Research;Biopsy;Cancer Biology;career;career development;Caucasians;Cell Line;Cells;Chemicals;Chemoresistance;chemotherapy;ChIP-seq;Clinical;clinical application;Competence;Computer Analysis;Data;Dependence;design;Detection;Development;Diagnosis;Disease;disease model;Distal;domain mapping;Doxycycline;Dysplasia;Early Diagnosis;Early Promoters;Early treatment;Elements;Endoscopy;Environment;Epithelial Cells;Esophageal Adenocarcinoma;Esophagus;established cell line;Ethnic Origin;experience;Family;Fluorouracil;Gastroenterologist;Gastroenterology;Gender;General Population;Genes;genetic analysis;genome-wide;Genomics;Goals;Growth;high risk;human model;Hyperactivity;immunodeficiency;Immunoprecipitation;improved;improved outcome;in vivo;Incidence;Induction of Apoptosis;Inhibition of Cell Proliferation;inhibitor;innovation;Intestines;Invaded;knock-down;Lesion;Ligands;male;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Maps;Mediating;Mediator;Mentors;Modeling;Molecular;Molecular Carcinogenesis;Mucous Membrane;Mus;mutant;Mutation;Neoplasm Metastasis;Neoplasms;new therapeutic target;Non-Malignant;novel;novel therapeutic intervention;Obesity;Oncogenic;Oral;Organoids;Pathway interactions;patient derived xenograft model;Patients;phase II trial;Physicians;Population;Pre-Clinical Model;premalignant;Prevalence;prevent;prognostication;programs;Property;protein protein interaction;receptor;Research;Research Proposals;Resistance;Risk;Risk Factors;Role;Scientist;screening;Signal Pathway;Signal Transduction;skills;small hairpin RNA;small molecule inhibitor;standard care;success;Survival Rate;synergism;Systems Biology;tandem mass spectrometry;targeted treatment;Testing;Tobacco use;Training;transcriptome sequencing;transcriptomic profiling;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Translational Research;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;tumor xenograft;tumorigenic;Unresectable;Veterans;Xenograft Model;Xenograft procedure

PROJECT_TITLE: TGFβ and Smad Signaling Components in Esophageal Adenocarcinoma


ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: For suicidal individuals, minimizing future risk and fostering recovery are critical public health concerns, especially among veterans, as very few effective interventions exist. Despite extensive VA resources targeting suicidal Veterans, suicide deaths number twenty daily. This project will conduct a randomized clinical trial in suicidal Veterans of a novel 10-session group psychotherapy treatment that combines emotion regulation skill based, and psychoeducational approaches, with suicide safety planning. The comparison condition is weekly individual safety planning. Assessments will occur at baseline, post treatment, six and twelve months. The primary outcome is suicidal behavior with secondary outcomes of hopelessness, depression and treatment utilization.

PI_NAMEs: GOODMAN, MARIANNE  (contact)

PROJECT_TERMS: Accident and Emergency department;adherence rate;Adult;Aftercare;Age;Ambulatory Care;Behavior Therapy;Caring;Cognitive Therapy;cohesion;Combined Modality Therapy;Communities;completed suicide;coping;Coping Skills;Data;design;Development;Development Plans;Dialectical behavior therapy;distress tolerance;effective intervention;Effectiveness;emotion regulation;Family;Feeling hopeless;Feeling suicidal;follow up assessment;follow-up;Fostering;Friends;Friendships;Funding;Future;group intervention;Group Psychotherapy;Guidelines;Guns;high risk;Hour;improved;Individual;Intervention;Learning;Life;Loneliness;Manuals;Mediating;Mental Depression;Mental Health;Methodology;Methods;military veteran;mobile application;Monitor;novel;novel strategies;Participant;Pattern;Personal Satisfaction;Philadelphia;Play;Population;post intervention;prevention service;primary outcome;psychoeducation;Public Health;Publishing;randomized, clinical trials;Recommendation;Recovery;Rehabilitation therapy;Reporting;research and development;Resources;Risk;Risk Factors;Role;Safety;secondary outcome;Site;skills;standard of care;Stress;suicidal;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide hotline;Suicide prevention;suicide rate;System;Telephone;Testing;therapy development;Time;Training;treatment as usual;treatment response;United States National Center for Health Statistics;Universities;Update;Veterans;Work

PROJECT_TITLE: Group (“Project Life Force”) vs. Individual Suicide Safety Planning RCT

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


ORG_CITY: SAN MARCOS

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Project Narrative The biomedical research community must include individuals from diverse backgrounds in order to foster scientific innovation and to increase the likelihood that the discipline will address issues of health disparities and the needs of underserved populations. The U-RISE Tx program will increase the number of Hispanic and other underrepresented undergraduate students who enroll in biomedical PhD programs and pursue research- related careers.

PI_NAMEs: KERWIN, SEAN M;LEWIS, KAREN ADELL (contact);MCLEAN, ROBERT JC

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Advertising;Advisory Committees;Automation;Biochemistry;Biology;Biomedical Research;Bobcat;Capital;career;career development;Chemistry;Communities;Decision Making;Development;Development Plans;Doctor of Philosophy;Educational workshop;Electronics;Ensure;Environment;Ethics;Event;evidence base;faculty mentor;faculty research;formative assessment;Fostering;Funding;Goals;graduate school;Hispanic;improved;Individual;innovation;Institution;Laboratories;meetings;Mentors;Mentorship;Methods;peer coaching;Preparation;programs;prospective;Protocols documentation;Qualifying;recruit;Reproducibility;Research;research and development;Research Project Grants;Research Training;responsible research conduct;Safety;Science;skills;social;Social Interaction;Structure;Students;success;synergism;Texas;Training;twelfth grade;undergraduate research;undergraduate research experience;Underrepresented Students;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: U-RISE at Texas State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Clinical Research;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Neurosciences;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: PROJECT NARRATIVE Blood-based biomarkers are urgently needed as alternative outcome measures in DMD. In this study, we seek to define monitoring biomarker signatures for DMD to assess disease course and changes in disease. We will use longitudinal serum samples including clinical data collected from well defined and well annotated cohorts and apply our internally developed and validated quantitative proteomics assays to develop such biomarker signatures. Finally, the signatures developed will be validated in external samples.

PI_NAMEs: DANG, UTKARSH J;HATHOUT, YETRIB  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Affinity;Age;Antibodies;aptamer;bench to bedside;Benchmarking;Biological Assay;Biological Markers;Biology;biomarker discovery;biomarker signature;Blood;blood-based biomarker;burden of illness;Calibration;candidate marker;Categories;Classification;Clinical;clinical biomarkers;Clinical Data;clinical predictors;Clinical Trials;cohort;Complement;Cox Models;Data;Decision Making;Diagnostic;Discrimination;Disease;Disease Progression;drug development;Duchenne muscular dystrophy;effective therapy;Ensure;Evaluation;follow-up;Future;Genes;Goals;Intervention;Knowledge;Literature;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;Monitor;Muscle;Myopathy;Netherlands;Outcome Measure;Pathogenesis;Patients;Performance;performance tests;Phase;Physicians;prognostic;Program Development;prospective;protein biomarkers;Proteins;Proteomics;Publishing;Reproducibility;response;Sampling;screening;Sensitivity and Specificity;Serum;Serum Proteins;Severity of illness;Signal Transduction;Specificity;Statistical Methods;tandem mass spectrometry;Testing;Time;tool;Training;Translating;Validation;Vital capacity

PROJECT_TITLE: Biomarker Signatures for Duchenne Muscular Dystrophy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: PROJECT NARRATIVE Women who initiate antiretroviral therapy (ART) during pregnancy in South Africa are at high risk of dropping out of care – particularly after delivery – but efforts to evaluate continuity of HIV care among pregnant and postpartum women have been hampered by lack of a national longitudinal HIV care database. Through this five-year award, we propose to use routinely-collected laboratory data to develop a national cohort of pregnant women living with HIV in South Africa that is uniquely robust to patient transfer. This novel cohort of pregnant women will be a powerful tool available to policymakers, clinicians and researchers for improving our understanding of engagement in care among pregnant women in South Africa and assessing the performance of the South African national ART program in caring for pregnant women living with HIV.

PI_NAMEs: CLOUSE, KATE ;MASKEW, MHAIRI  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Address;antenatal;antenatal care;antiretroviral therapy;Award;Big Data;Blood specimen;Blood Tests;Breast Feeding;Caring;CD4 Lymphocyte Count;Clinical;Clinical Data;cohort;Continuity of Patient Care;Country;Data;data tools;Databases;design;Development;Drops;Ensure;Epidemiology;follow-up;Frequencies;General Population;Guidelines;Health;health economics;Health Services Accessibility;high risk;High Risk Woman;HIV;Home;improved;Individual;Infant;innovation;Intervention;Knowledge;Laboratories;Machine Learning;Measures;Monitor;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Movement;novel;patient mobility;Patient Transfer;Patients;Performance;Perinatal;Persons;Policies;Policy Maker;Population;post pregnancy;postpartum care;Postpartum Period;Postpartum Women;predictive modeling;Pregnancy;Pregnant Women;programs;Provider;Public Sector;Research Personnel;Risk;Risk Factors;Series;Services;Sexual Partners;Site;South Africa;South African;Specific qualifier value;success;System;Techniques;Testing;Time;tool;transmission process;treatment program;trend;Vertical Disease Transmission;Viral;Viral Load result;viral transmission;Viremia;Woman;Work

PROJECT_TITLE: The South African National HIV Pregnancy Cohort: evaluating continuity of care among women living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-N(53)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Physical Rehabilitation;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative The purpose of this project is to measure articulatory and prosodic sensorimotor adaptation in interactions between a speaker and listener. Our understanding of speech motor control is based on strong evidence of sensorimotor adaptation in articulation and prosody, but thus far only in speech without communicative intent. This project will therefore provide the empirical evidence needed to extend current models of speech motor control to ecologically valid interactions between a speaker and a listener and to inform interventions that use external feedback to bolster impaired articulatory and prosodic control in clinical populations.

PI_NAMEs: DAHL, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Articulatory and prosodic sensorimotor adaptation in speaker-listener interactions


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Physical Activity;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE It is well known that physical inactivity is linked to poor health and lower quality of life; recent work has shown that how active an individual is during childhood can alter the structure of bones, joints, and muscles in such a way that the capacity for exercise as an adult would be affected. This project explores how growth-period exercise prescription can reverse the effects of inactivity by documenting altered anatomy, function, and ultimately the effects on adult exercise behavior. Fundamental knowledge arising from this work will allow us to optimize musculoskeletal structure and function through targeted physical activity in childhood to enhance lifelong health and mobility.

PI_NAMEs: PIAZZA, STEPHEN J;RUBENSON, JONAS  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Anatomy;Animal Model;Animals;Architecture;Behavior;Biological Models;Biomechanics;Birds;bone;Bone structure;Childhood;Chronic;Computer Simulation;Control Groups;critical period;Disease;Dose;early onset;Environment;Ethics;evidence base;Excision;Exercise;exercise capacity;exercise prescription;Exercise Therapy;exercise training;Exhibits;experimental study;Goals;Growth;Guinea;Habits;Health;Health Care Costs;Human;improved;Individual;Intervention;Joints;Knowledge;Life;life span;Link;Mechanics;Metabolic;Modeling;Morbidity - disease rate;Morphology;mortality;Movement;Mus;Muscle;muscular structure;Musculoskeletal;Musculoskeletal Development;Musculoskeletal structure;Musculoskeletal System;Nature;Outcome;pandemic disease;Pathway interactions;Persons;Physical activity;physical inactivity;Physiological;Population;postnatal;Public Health;Quality of life;Reaction Time;Recommendation;Research;response;sedentary lifestyle;stem;Structure;Tendon structure;Testing;Tissues;Work;Writing

PROJECT_TITLE: Active Growth, Active Life: Eliminating Biomechanical Barriers to Physical Activity through Growth-Period Exercise

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 10 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

PI_NAMEs: HOWELL, DAVID R. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: 18 year old;Acute;Adolescent;Aerobic Exercise;Affect;Age;Anxiety;Biological Markers;Brain Concussion;cardiovascular health;cerebrovascular;Cerebrovascular Physiology;Childhood;Clinical;Clinical Trials Design;Collaborations;concussive symptom;Critical Illness;Data;Data Reporting;design;Development;dosage;Dose;effective therapy;Enrollment;Exercise;exercise intensity;Exercise Physiology;exercise prescription;exercise program;Exercise Therapy;experience;Frequencies;Functional disorder;global health;Guidelines;high standard;Hour;Impairment;improved;Inflammation;Inflammatory;Injury;Instruction;interdisciplinary approach;Interleukin-6;Intervention Trial;Light;Link;Liquid substance;Mediating;Mental Depression;Moderate Exercise;multidisciplinary;National Institute of Child Health and Human Development;Nature;neuroinflammation;Neurologic Dysfunctions;neurophysiology;Observational Study;optimal treatments;Patient Self-Report;Patients;pediatric trauma;peer;Physical activity;Physiological;Physiology;precision medicine;prevent;prospective;psychosocial;psychosocial outcome;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recovery;Regulation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Priority;Resolution;response;Rest;Secondary Prevention;Serum;Severities;Site;Sports;standard of care;Symptoms;Testing;Therapeutic Effect;Time;timeline;Traumatic Brain Injury;Traumatic injury;treatment response;Visit;Work

PROJECT_TITLE: Modulating Exercise Dosage to Improve Concussion Rehabilitation: A Randomized Clinical Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVEaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Bronchopulmonary dysplasia (BPD) is the most common lung disease in premature neonates, characterized by long-term respiratory disability, frequent hospitalizations, and high healthcare costs. This proposal will validate a genomic tool that may predict which neonates are at risk for developing BPD. Moreover, we will examine whether an FDA-approved biologic can mitigate genetic changes found to be associated with BPD risk.

PI_NAMEs: MOREIRA, ALVARO G (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Adopted;Adrenal Cortex Hormones;Animal Model;Archives;Asthma;Beds;biobank;Bioinformatics;Biological;Biological Products;biomarker discovery;Birth Weight;Blindness;Blood;Blood specimen;Body Weight;Bronchopulmonary Dysplasia;career;Childhood;Chronic;Clinical;Clinical Research;Clinical Trials;clinically significant;cohort;Coughing;Coupled;Custom;Data;Development;Diagnosis;disability;Disease;Double-Blind Method;Education;efficacy testing;eosinophil;experience;Exposure to;extreme prematurity;FDA approved;Future;Gene Expression;Genes;genetic signature;Genomic approach;genomic profiles;genomic signature;genomic tools;Genomics;Goals;Health Care Costs;Health Sciences;Hospitalization;Human;Hyperoxia;Immunity;Immunology;Impairment;improved;Inflammation;Injury;innovation;Institution;Instruction;Knowledge;Learning;Life;Lung;lung development;Lung Diseases;lung injury;Medicine;Mental deficiency;Mentored Patient-Oriented Research Career Development Award;Mentors;Modality;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mutation;nano-string;Neonatal;Neonatal Intensive Care Units;neonatal lung disease;neonate;novel;novel strategies;Outcome;Papio;Pathologic Processes;Pathway interactions;Patient Care;patient oriented;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Physicians;Physiology;predictive signature;Predisposition;Pregnancy;preterm newborn;prevent;Prevention;Prevention strategy;Preventive;Primary Prevention;Process;professor;prospective;pulmonary function;Pulmonary Hypertension;randomized, clinical trials;Recurrence;Research;respiratory;Respiratory Tract Infections;Risk;Risk Factors;risk stratification;Safety;Scientist;Secondary to;Severities;Severity of illness;Site;skills;surfactant;Symptoms;T-Lymphocyte;Technology;Testing;Texas;text searching;therapeutic target;Time;Tissues;tool;Training;transcriptome sequencing;transcriptomics;translational genomics;Universities;Validation;Ventilator;Ventilator-induced lung injury;Wheezing;whole genome

PROJECT_TITLE: Genomic determinants of bronchopulmonary dysplasia development in humans and an animal model

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: RONDEBOSCH

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative There is a significant need for large-scale African studies that examine the size and make-up of the latent viral reservoir that exists in HIV-infected individuals on antiretroviral treatment. This project proposes to transfer a newly reported highly accurate reservoir sizing method developed using American populations to measure reservoir size in South African women, and to investigate the role of multiple viral factors in reservoir size and composition. The contribution of viral variants from the blood and cervix to the reservoir will also be explored.

PI_NAMEs: ABRAHAMS, MELISSA-ROSE  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;Address;Affect;Africa;African;African Women;Aftercare;American;Anatomy;antiretroviral therapy;Area;Attention;Bioinformatics;Biological Assay;Biological Markers;Blood;Cells;Cervical;Cervix Uteri;Characteristics;Chronic;cohort;Collaborations;computerized data processing;design;DNA;Down-Regulation;Flow Cytometry;Genetic Transcription;Genome;Genotype;HIV;HIV-1;Immune Evasion;in vitro Assay;Individual;Infection;interest;Jurkat Cells;Kinetics;Knowledge;Laboratories;Long Terminal Repeats;Measures;Mediating;men;Methods;Modeling;nef Genes;nef Protein;next generation sequencing;Ontario;Population;Recombinants;Reporting;Role;skills;South Africa;South African;Standardization;study population;System;Techniques;Technology;Technology Transfer;Testing;Training;Uganda;Universities;Vagina;Variant;Viral;Viral Physiology;Viral Proteins;viral rebound;Viral reservoir;Virus;Virus Latency;Woman;Work

PROJECT_TITLE: Characterizing intact proviral HIV-1 reservoir size and determinants of reservoir dynamics in African populations


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Relevance of the proposed research to Veterans’ health issues: Many military personnel and Veterans incur joint injuries that can result in development of post-traumatic osteoarthritis (PTOA), and many others develop OA from other etiologies. This proposal will perform proteomic, immunostaining, and RNA-Seq analyses to define immune pathotypes of OA. Success would transform our mechanistic understanding of OA, and identify targets for therapeutics to treat pain and prevent progression.

PI_NAMEs: ROBINSON, WILLIAM H (contact)

PROJECT_TERMS: Age;Animal Model;Anti-Inflammatory Agents;Biological Markers;biomarker development;bone;burden of illness;Caring;Cartilage;Cell Line;Cells;Chronic disability;chronic pain;Clinical;Clinical Data;Clinical Trials;cohort;Complement;Complement Activation;complement system;cytokine;Data;Data Set;Degenerative polyarthritis;Development;Disease;Disease Pathway;Early treatment;Environment;Etiology;Fibroblasts;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Health;Healthcare Systems;Heterogeneity;Histologic;Human;human tissue;Immune;improved;Inflammation;Inflammatory;Informatics;joint injury;Joints;Laboratories;Machine Learning;Macrophage;mast cell;Mechanics;Mediator;meniscal tear;Military Personnel;military veteran;Molecular;Molecular Disease;Molecular Profiling;Mus;Nerve;Nerve Growth Factors;new therapeutic target;novel therapeutic intervention;osteoarthritis pain;Outcome;Pain;pain reduction;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;prevent;Proteomics;radiological imaging;Research;response;Sampling;Serum;single-cell RNA sequencing;specific biomarkers;Stem Cell Factor;Stratification;success;Synovial Fluid;Synovial Membrane;targeted treatment;Testing;Therapeutic;Tissues;transcriptome sequencing;Traumatic Arthropathy;treatment response;United States National Institutes of Health;Veterans

PROJECT_TITLE: BCCMA: Targeting Osteoarthritis Pain and Progression: Proteomics, RNASeq & Immunostaining to elucidate the immune pathotypes of OA


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The development of the dopamine system is a tightly regulated process that has great implications on social and reward associated behaviors. Microglia, the resident immune cells of the brain, selectively engulf (phagocytose) dopamine receptors during adolescent development, however, what regulates this microglia function remains unknown. I will investigate the role of dopaminergic signaling in regulating microglial chromatin remodeling and phagocytic function through adolescence impacting social behavior—providing necessary foundational knowledge on microglial development in a key reward associated brain region.

PI_NAMEs: CLARK, MADELINE J (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Adolescent Development;Adult;Animal Experiments;Animals;ATAC-seq;Automobile Driving;Behavior;Biological Assay;Biology;brain cell;Brain region;brain reward regions;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;comparison control;Control Animal;Control Groups;Cues;Data;density;Development;DNA;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;dopamine system;Down-Regulation;drug of abuse;Epigenetic Process;epigenetic regulation;Etiology;Exhibits;Female;Fiber;Future;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genomic locus;Genomics;glial cell development;Goals;Histones;Immune;Immunohistochemistry;Knowledge;male;Mediating;Microglia;Motivation;neural;Neuroimmune;Neurons;novel;Nucleus Accumbens;p38 Mitogen Activated Protein Kinase;Phagocyte Bactericidal Dysfunction;Phagocytes;Phagocytosis;phagocytosis receptor;Play;Process;Property;Rattus;receptor;receptor density;Regulation;Rewards;Risk;Role;Sampling;sex;Signal Transduction;social;Social Behavior;Stimulus;Substance Use Disorder;Synapses;synaptic pruning;Systems Development;Testing;Time;transcriptome sequencing;Ventral Tegmental Area;Work

PROJECT_TITLE: Epigenetic Regulation of Microglia Dopamine System Interactions


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Antibiotic overuse at hospital discharge is an overlooked contributor to patient harm, as it leads to adverse events, such as Clostridioides difficile infection and antibiotic resistance. This project will generate new knowledge on predictors, barriers, and solutions to antibiotic overuse at hospital discharge, thus improving the care of hospitalized patients.

PI_NAMEs: VAUGHN, VALERIE MICHELE (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Engaging Hospitalists to Improve Antibiotic Prescribing at Hospital Discharge

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This NIDDK K23 Career Development Award application seeks to evaluate the feasibility of the use of hybrid closed loop insulin pumps to support diabetes management in patients with poorly controlled Type 1 diabetes from diverse backgrounds and will explore barriers and facilitators to use in this population. This study will inform a future NIDDK R01 application to evaluate the effectiveness in a large scale RCT which will address critical gaps in knowledge and potential misconceptions about technology use in higher risk populations.

PI_NAMEs: EVERETT, ESTELLE MARLA (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: access disparities;Achievement;Address;Adult;Algorithms;American;Area;Award;basal insulin;Blood Glucose Self-Monitoring;Blood Vessels;Bypass;Calibration;care burden;Caring;Cessation of life;Clinical;clinical care;Clinical Trials;Clinical Trials Design;Complex;Computerized Medical Record;Continuous Glucose Monitor;County;Data;Data Analyses;Data Collection;design;Development;diabetes control;diabetes management;Diabetes Mellitus;Disparity;Documentation;Dose;Education;effectiveness evaluation;efficacy evaluation;Electronic Health Record;Endocrinologist;Enrollment;ethnic minority;Evaluation;Exclusion;experience;Fingers;Funding;Future;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;health care settings;Health Services;Health system;Healthcare Systems;Hemoglobin;high risk;high risk population;Hybrids;improved;improved outcome;Injections;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;interest;Intervention;K-Series Research Career Programs;Knowledge;Los Angeles;low health literacy;low socioeconomic status;Medical;Mentored Patient-Oriented Research Career Development Award;Methods;monitoring device;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Language Processing;new technology;novel;Outcome;Paper;Patient Care;patient oriented;patient population;Patients;Population;Positioning Attribute;Principal Investigator;Publishing;Pump;Quality of life;racial minority;Randomized, Controlled Trials;real time monitoring;Recommendation;Research;Research Personnel;Research Training;Risk;safety net;satisfaction;Self Management;sensor;Series;skills;Socioeconomic Status;System;Technology;Time;Training;Vulnerable Populations

PROJECT_TITLE: Hybrid Closed Loop Insulin Pump use in Poorly Controlled Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This study aims to establish the essential role of a unique immune cell subset, TFR cells, in tumorigenesis, and reveal an unconventional mechanism by these cells adopt to promote cancer. Insights gained from this project will open a new avenue of investigation in the field of cancer research, and formulate new immunotherapeutic approaches to treat cancer.

PI_NAMEs: LEAVENWORTH, JIANMEI WU (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Adopted;Adoptive Transfer;anti-cancer research;Area;Autonomic Dysfunction;Autonomic nervous system;axonal sprouting;Biological Assay;Cancer Patient;Cells;Fostering;FOXP3 gene;Frequencies;Gene Modified;genetic signature;Goals;Hormones;Human;Immune;Immune Evasion;Immune system;Immunofluorescence Immunologic;Immunotherapeutic agent;In Vitro;in vivo;Infiltration;innovation;insight;Investigation;Location;Malignant - descriptor;Malignant Neoplasms;Modeling;Mus;Nature;Neoplasm Metastasis;Nerve;Nerve Fibers;nerve supply;neurofilament;neuroregulation;neurotrophic factor;patient prognosis;Peripheral;Peripheral Nerves;PRDM1 gene;Psychological Stress;reconstitution;Regulation;Regulatory T-Lymphocyte;Reporting;Research;response;retroviral-mediated;Risk;Role;Stains;Testing;therapy resistant;Tissues;transcription factor;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis

PROJECT_TITLE: Hijacking the Blimp1-Neuritin Axis to Promote Cancer by Follicular Regulatory T-cells

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: The proposal resolves a longstanding conflict and presents a unified metabolic model to understand β-cell nutrient-sensing and health. It will broadly advance the field of islet translational research and help identify at the outset which targets have long-term clinical efficacy or failure. In addition, the two-state metabolic model supports a preclinical rationale for targeting phasic metabolism for therapeutic benefit.

PI_NAMEs: KIBBEY, RICHARD G (contact);MERRINS, MATTHEW J.

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Agonist;Animal Model;Beta Cell;Biochemical;Biophysics;blood glucose regulation;Carbon;Cell Line;Cell membrane;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Citric Acid Cycle;clinical efficacy;Conflict (Psychology);Coupling;detection of nutrient;diabetogenic;Diet;Disputes;Electrophysiology (science);Exocytosis;Failure;Fructose;G-Protein-Coupled Receptors;Generations;Genetic;Glucokinase;Glucose;Health;Human;Hydrolysis;Imaging Techniques;improved;in vivo;Insulin;insulin secretion;islet;Link;Mediating;Membrane;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Mus;oxidation;Oxidative Phosphorylation;pharmacologic;Pharmacotherapy;Phase;phenomics;Phosphoenolpyruvate;Phosphoenolpyruvate Carboxylase;Physiological;pre-clinical;Privatization;Proton-Motive Force;Pyruvate Carboxylase;pyruvate dehydrogenase;Pyruvate Kinase;Reaction;Regulation;Reporter;Rodent;Signal Transduction;stable isotope;Structure of beta Cell of islet;Testing;Theft;Therapeutic;Time;tool;Translational Research;voltage

PROJECT_TITLE: Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Obesity and diabetes rates continue to rise, and racial and gender disparities persist. Limiting how much weight women gain in pregnancy reduces future obesity and diabetes for many women and their children. We compare the effectiveness of Healthy for Two / Healthy for You, a telephonic and web-based health coaching program integrated into prenatal care, among 380 racially and economically diverse pregnant and postpartum women, aimed at reducing excess pregnancy weight gain, future obesity and diabetes.

PI_NAMEs: BENNETT, WENDY LYNET (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adult;African American Women;Age;arm;Behavior;Behavior Therapy;Behavioral;Birth;Birth Weight;Body Weight decreased;Breast Feeding;care delivery;Caring;Cellular Phone;Child;child bearing;Clinic;clinical practice;combat;Communities;Community Health Aides;comorbidity;compare effectiveness;cost;Cost Analysis;Counseling;design;Development;Diabetes Mellitus;Diet;dietary;Discipline of obstetrics;Effectiveness;effectiveness testing;efficacy testing;efficacy trial;Enrollment;Ensure;evidence base;Exercise;experience;Future;gender disparity;Gestational Diabetes;gestational weight gain;Goals;Health;Health behavior;Health system;health training;High Risk Woman;implementation intervention;improved;Incidence;Infant;innovation;intergenerational;Intervention;intervention cost;intervention delivery;Interview;Investments;lifestyle intervention;Low Birth Weight Infant;Maternal Health;men;Mental Depression;mobile computing;mortality;Mothers;motivational enhancement therapy;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity prevention;obesity risk;Online Systems;Outcome;Patient Monitoring;Persons;Physical activity;population health;Population Heterogeneity;postpartum health;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;prenatal;Prenatal care;prevent;Prevention;primary outcome;programs;Provider;Public Health;Publications;Quality of Care;Race;racial disparity;randomized, clinical trials;Randomized, Controlled Trials;remote delivery;reproductive;Research;Research Personnel;Resources;Risk;satisfaction;secondary outcome;Sleep;Stress;Structure;Technology;Telephone;telephone coaching;Testing;treatment as usual;web platform;Weight;Weight Gain;Weight maintenance regimen;Woman;young adult

PROJECT_TITLE: Healthy for 2/Healthy for U: A Pragmatic Randomized Clinical Trial to Limit Gestational Weight Gain and Prevent Obesity in the Prenatal Care Setting


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA CITY VA MEDICAL CENTER

ORG_STATE: OK

PHR: Project Narrative Osteoarthritis (OA) is an exceptionally common problem among veterans, is associated with a number of other medical conditions, and is a leading cause of disability among veterans. Recent research has demonstrated that the gut and cartilage microbiomes are altered in association with OA. A better understanding of how aging, obesity, and trauma influence these microbiomes may lead to new insights into the causes of OA and give rise to new treatments for OA patients. We will study these microbiome patterns in the context of veterans with OA and in OA animal models.

PI_NAMEs: JEFFRIES, MATLOCK  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adult;Affect;Age;age-related disease;Aging;Animal Model;Animals;ATAC-seq;Bacterial Genes;behavioral outcome;bisulfite;bisulfite sequencing;Cadaver;Cartilage;Cells;Chondrocytes;Chromatin;Chronic;Chronic disability;Chronic Disease;chronic pain;Clinical;Clinical Data;cohort;cytokine;Cytometry;Data;Data Set;Degenerative polyarthritis;Development;Dietary Intervention;disability;Disease;DNA;DNA amplification;DNA Methylation;draining lymph node;Epigenetic Process;epigenome;Exposure to;Failure;fecal transplantation;Future;General Population;genome-wide;Germ-Free;Goals;gut microbiome;Histologic;Human;human old age (65+);immune activation;In Vitro;Incidence;Inflammation;Inflammatory;Infrastructure;innovation;insight;Joints;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Laboratories;Link;Machine Learning;machine learning model;Measures;Medial meniscus structure;Mediating;Medical;microbial;microbial products;microbiome;microbiome alteration;microbiome analysis;microbiome research;microbiota transplantation;Modeling;mouse model;Mouse Strains;Mus;Musculoskeletal Diseases;next generation;next generation sequencing;Non obese;non-genetic;normal aging;novel;novel therapeutic intervention;Obesity;Oligonucleotides;Operative Surgical Procedures;Outcome;Pain;Pathology;Pathway interactions;Patients;Pattern;Peripheral;peripheral blood;Positioning Attribute;Predisposition;prevent;Publishing;recruit;Reporting;Research;Resistance;Risk;Risk Factors;Sampling;Serum;Severities;Shapes;Specific qualifier value;Specimen;Splenocyte;stool sample;subchondral bone;success;Synovial Membrane;Techniques;Testing;Therapeutic Agents;Tissues;Transplantation;Trauma;treatment strategy;Veterans;whole genome;Work

PROJECT_TITLE: Cartilage Microbial Products as Novel Drivers of Knee Osteoarthritis Epigenetic Dysregulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: The α1A-adrenergic receptor subtype has been shown in vivo and in vitro to be expressed in the cognitive centers of the brain, is both cardiac and neuroprotective, and can increase cognitive functions, synaptic plasticity, and long term potentiation. This grant will determine if highly-selective and novel α1A- adrenergic receptor positive allosteric modulators we developed may be improved upon in its in vitro and in vivo pharmacology to ultimately demonstrate its usefulness in ameliorating the cognitive decline and brain function in Alzheimer's Disease without affecting blood pressure. In light of current disappointing clinical trials using anti-amyloid β antibodies, a pharmaceutical approach that can regenerate the brain and/or reverse cognitive decline is urgently needed.

PI_NAMEs: PEREZ, DIANNE M (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3-Dimensional;3xTg-AD mouse;Adrenergic Receptor;adult neurogenesis;Affect;Affinity;aged;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;analog;Animal Model;animal model development;Animals;antagonist;Antibodies;Apoptotic;Area;Behavior;beta-Galactosidase;Binding;Biodistribution;Biological;Biological Assay;Biological Availability;Blinded;Blood Pressure;blood pressure elevation;Brain;Calcium;Cardiac;cardiovascular effects;Characteristics;Chemicals;Chronic;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive enhancement;cognitive function;Cyclic AMP;Data Analyses;density;Derivation procedure;Disease;Distant;Dose;drug development;Drug Industry;efficacy study;Epinephrine;extend lifespan;fluorescence imaging;follow-up;G-Protein-Coupled Receptors;Grant;Hippocampus;Hormones;Imaging technology;Immunotherapy;Impaired cognition;improved;In Situ;In Vitro;in vivo;innovation;Inositol Phosphates;Knockout Mice;Laboratories;Lead;Learning;Ligands;Light;Long-Term Potentiation;Marketing;Measures;Mediating;Memory;Methods;Modeling;Molecular;Molecular Conformation;Molecular Weight;mouse model;Mus;Mutation;Natural regeneration;Nerve Degeneration;Neurofibrillary Tangles;neurogenesis;neuron loss;neuroprotection;neurotransmission;Norepinephrine;novel;novel drug class;novel strategies;novel therapeutics;Oral;overexpression;Penetrance;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phenotype;Play;positive allosteric modulator;Property;Publishing;radiotracer;Rapid screening;Rattus;receptor;Receptor Activation;receptor binding;Reflux;Reporting;Research;response;Rodent Model;Role;Senile Plaques;side effect;Signal Transduction;Site;Structure;Synapses;synaptic function;Synaptic plasticity;System;targeted agent;tau Proteins;Therapeutic;Time;Toxic effect;Transgenic Animals;Transgenic Mice;vasoconstriction

PROJECT_TITLE: Early Stage Studies of a Novel Positive Allosteric Modulator of  the Alpha1-Adrenergic Receptor to Treat Alzheimer's Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Given the increasing health and economic burdens associated with the burgeoning number of Alzheimer’s disease (AD) cases throughout the world, there is an urgent need to develop therapeutic agents that can treat, delay, or prevent the disease. However, development of effective new therapies has been hindered by a lack of the skills and knowledge required to perform scientifically rigorous preclinical drug-screening studies, which are typically carried out using laboratory mice. This proposal aims to address these gaps by developing and delivering a workshop at The Jackson Laboratory, a world-renowned center of expertise in the analysis of mouse models, that will provide participants with hands-on training and lecture instruction that will enable the rigorous design, execution, analysis, and reporting of preclinical experiments that will have potential to bring new AD therapies to the clinic.

PI_NAMEs: RIZZO, STACEY J (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer's disease therapy;animal imaging;Animal Model;Bioinformatics;Biological Process;Clinic;Clinical;Clinical Trials;Collaborations;Communication;Communities;Complex;Data;Data Analyses;Data Reporting;design;Development;Disease;drug discovery;Drug Kinetics;Drug Screening;drug testing;Economic Burden;Education;Educational workshop;Ensure;Environment;Evaluation;experience;Experimental Designs;experimental study;Faculty;FarGo;FDA approved;Fostering;genome editing;Genomic approach;Goals;graduate student;Guidelines;Health;Human;Immersion;improved;in vivo;in vivo evaluation;Indiana;Individual;innovation;Institution;Instruction;International;Knowledge;Laboratories;laboratory experience;Laboratory mice;Late Onset Alzheimer Disease;lectures;Methodology;Methods;model organism;mouse genetics;mouse model;Mus;novel therapeutics;Participant;patient population;Patients;Pharmaceutical Preparations;Pharmacodynamics;Postdoctoral Fellow;pre-clinical;precision medicine;preclinical efficacy;preclinical study;Preclinical Testing;prevent;Process;Public Health;Publications;Reporting;Reproducibility;Research;Research Personnel;residence;Resources;Sample Size;Scholarship;Scientist;screening;skills;statistics;Students;symposium;Techniques;The Jackson Laboratory;Therapeutic Agents;Therapeutic Intervention;tool;Training;Translating;translational medicine;Translations;United States National Institutes of Health;Universities

PROJECT_TITLE: Improving Preclinical Translation in Alzheimer's Disease Research

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: NARRATIVE The noteworthy similarities and the differences between sound location processing in birds and mammals show there are many ways of localizing sounds and separating sources from background noise; these different strategies can inspire the development of new technologies such as cochlear implants. Current binaural implants work independently, so that the timing of pulses is not synchronized or coordinated between the ears, and much of the fine temporal structure required for effective ITD processing is not preserved. In the broader context, understanding the development of temporal fine structure should reveal common constraints on the development of binaural hearing to guide technological advances.

PI_NAMEs: CARR, CATHERINE EMILY (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Address;Adult;Animal Model;Animals;Area;attenuation;Audiology;Auditory;Auditory system;Axon;Barn Owls;Bilateral;Binaural;binaural hearing;Birds;Brain Stem;Cell Nucleus;Clinic;Cochlear Implants;Cochlear nucleus;Code;Conductive hearing loss;critical period;Data;deafness;deprivation;Detection;Development;Discrimination;Ear;early experience;Environment;experience;experimental study;External auditory canal;extracellular;Frequencies;gamma-Aminobutyric Acid;Goals;Growth;hatching;Head;Hearing;Hearing Aids;Human;Impairment;Implant;implant design;in vivo evaluation;Inhibitory Synapse;Iontophoresis;Knowledge;language perception;Learning;Location;Mammals;Maps;Measurement;Measures;millisecond;Modeling;Modification;Myelin;myelination;Nature;nerve supply;Neurons;new technology;Nodal;Noise;normal hearing;Persons;Phase;Physiologic pulse;Physiological;Physiology;Population;Preparation;Process;programs;Reproducibility;Research;Role;Signal Transduction;sound;Sound Localization;Source;Speech Perception;Strigiformes;Structure;System;Technology;Testing;Thick;Time;Work

PROJECT_TITLE: Development of Temporal Fine structure

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]