NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE PD1 and LAG3 are critical mediators of tolerance and prevent autoimmunity, but limit effective immunity to  cancer and chronic infections. A mechanistic understanding of PD1/LAG3 interactions is needed to learn how  to optimally modulate these receptors to treat cancer, chronic infection and autoimmunity. Project 1 will define  cellular and molecular mechanisms by which PD1 and LAG3 regulate tolerance and autoimmunity.

PI_NAMEs: SHARPE, ARLENE H. (contact)

PROJECT_TERMS: Affect;Agonist;anti-PD-1;antiviral immunity;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Blocking Antibodies;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Fate Control;cell type;Cells;Chronic;chronic infection;Clinical;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;data exchange;Data Set;Development;Disease;Disease remission;Effector Cell;effector T cell;Equilibrium;Event;exhaustion;Experimental Autoimmune Encephalomyelitis;Experimental Models;FOXP3 gene;Funding;Gene Deletion;Genetic;Genetic Transcription;Goals;Histologic;Immune;immune checkpoint blockade;immune-related adverse events;Immunity;immunopathology;Immunotherapy;improved;Inbred NOD Mice;Individual;Infection;Knockout Mice;Learning;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Mediator;Molecular;Molecular Analysis;Mouse Strains;Mus;Myelin;novel;Oligodendroglia;Outcome;overexpression;Pathogenicity;Pathway interactions;PD-1 blockade;Peripheral;peripheral tolerance;Phase;Play;prevent;programmed cell death protein 1;Progressive Disease;Publishing;receptor;Regulatory T-Lymphocyte;Relapse;Resolution;response;Role;Severities;Signal Transduction;synergism;System;systemic autoimmunity;T cell differentiation;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The inhibitory receptors PD1 and LAG3 synergize to limit autoimmune disease. However, they are highly  expressed on intratumoral T cells and thus limit effective anti-tumor immunity. Although PD1 and LAG3 are now  major therapeutic targets, it is not clear how they mediated this synergistic regulation and on which cells types.  A greater understanding of these issues could lead to move effective therapeutic strategies and biomarker  discovery.

PI_NAMEs: VIGNALI, DARIO AA (contact)

PROJECT_TERMS: Alleles;anti-PD-1;antiviral immunity;Autoimmune;Autoimmune Diseases;biomarker discovery;biomarker identification;cancer care;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cell surface;cell type;Cells;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;data exchange;Development;Disease;Disease remission;effector T cell;Event;exhaust;exhaustion;Functional disorder;Genetic;Genetic Transcription;Health;Immune;Immunity;inhibitory surface receptor;Maintenance;Malignant Neoplasms;Maps;Mediating;Memory;Metabolic;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;neoplasm immunotherapy;Neoplasm Metastasis;novel;Pathway interactions;Patients;PD-1/PD-L1;Population Dynamics;Process;programmed cell death protein 1;Publishing;receptor;Regulation;Regulatory T-Lymphocyte;response;Role;Signal Transduction;Staging;synergism;System;T cell response;T cell therapy;T memory cell;T-Cell Development;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic target;therapeutically effective;tool;trial design;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Viral;Virus Diseases

PROJECT_TITLE: Project 2 - Modulation of Anti-Tumor Immunity by Inhibitory Receptors


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Diabetes mellitus (DM) occurs in about 1 in every 4 persons after an episode of acute pancreatitis (AP) making this an important health problem, but the mechanisms underlying DM after AP remain unknown. We will enroll adults with AP into a multicenter longitudinal observational study supported by the Type 1 Diabetes in Acute Pancreatitis Consortium and define mechanisms of DM by: (1) measuring insulin secretion and insulin sensitivity after AP; and (2) determining relative contribution of autoimmunity (type 1 DM) by assessing beta cell autoantibodies and T cell reactivity to beta cell antigens in study participants.

PI_NAMEs: BELLIN, MELENA D. (contact);TRIKUDANATHAN, GURU V

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abate;Accident and Emergency department;Acinar Cell;acute pancreatitis;Address;Adult;Affect;American;Antibodies;Antigens;Autoantibodies;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;B-Lymphocytes;Beta Cell;biobank;Bioinformatics;Biological Markers;CD8-Positive T-Lymphocytes;Cell Death;Cell Physiology;Cells;Cellular Stress;Cessation of life;Childhood;chronic pancreatitis;Clinic;clinical center;clinical risk;cohort;cytokine;Data;Defect;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Endocrine;Enrollment;Environmental Exposure;Epidemiology;Event;Exhibits;Exocrine pancreas;experience;Frequencies;Functional disorder;gastrointestinal;Genetic Markers;Glucose;Goals;Health;high risk;Hospitalization;Hospitals;human leukocyte antigen testing;Hyperglycemia;Immune;Immunologics;Immunology;improved;Individual;Infiltration;Inflammation;inflammatory milieu;injured;Injury;Insulin deficiency;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;International;Intravenous;intravenous glucose tolerance test;islet;Longitudinal cohort;Longitudinal Studies;Longitudinal, observational study;Macrophage;Measures;medical specialties;Metabolic;Metabolic dysfunction;Minnesota;multimodality;neoantigens;neutrophil;Oral;Oxidative Stress;Pancreas;Pancreatic Injury;Pancreatitis;Participant;Patient Recruitments;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Post-Translational Protein Processing;Predisposition;Prevalence;prevent;Recording of previous events;recruit;Recurrence;Research Personnel;response;Risk;Risk Factors;Role;Sampling;Self Tolerance;Serum;Signal Transduction;Stimulus;Subjects Selections;T-Lymphocyte;Testing;tissue injury;Tissues;Universities;Work

PROJECT_TITLE: University of Minnesota Clinical Center for the Study of Acute Pancreatitis and Diabetes


PHR: Project Narrative Chronic infections with viruses such as HIV, HCV and HBV affect half a billion people and are significant  causes of morbidity and mortality. T cell dysfunction or “exhaustion” is a major immunological defect during  these infections and can be modeled with LCMV infection in mice. The studies proposed will define the role of  the inhibitory receptors PD1 and LAG3 in CD8+ T cell exhaustion and provide new insights into how to reverse  and avoid T cell exhaustion and improve immunity during these and other chronic infections.

PI_NAMEs: WHERRY, E. JOHN (contact)

PROJECT_TERMS: Affect;Antibodies;antiviral immunity;Autoimmunity;Bioinformatics;Biology;CD8-Positive T-Lymphocytes;CD94 Antigen;cell growth regulation;Cells;Chronic;chronic infection;Clinical;clinically relevant;CRISPR screen;Data;data exchange;Defect;Development;Developmental Biology;Epigenetic Process;Event;Excision;exhaust;exhaustion;Experimental Models;flexibility;Functional disorder;Genetic;Genetic Transcription;Hepatitis B Virus;Hepatitis C virus;Heterogeneity;HIV;Human;Immune;immune checkpoint blockade;Immunity;Immunologics;improved;in vivo;Individual;Infection;insight;Link;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Maps;Mature T-Lymphocyte;Memory;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mus;novel;novel therapeutics;nuclear factors of activated T-cells;Pathology;Pathway interactions;PD-1 blockade;Persons;Population;Population Dynamics;prevent;progenitor;programmed cell death protein 1;programs;Publishing;receptor;Resolution;response;Role;Signal Transduction;synergism;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;tumor;Virus;Virus Diseases

PROJECT_TITLE: Project 3 - Modulation of Antiviral Immunity and T cell Exhaustion by Inhibitory Receptors


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE: Macular Degeneration is a disease that forces individuals to rely on the low resolution of peripheral vision to perform everyday visual tasks. Understanding how the brain’s visual system adapts to using peripheral vision could potentially aid in the development of behavioral interventions for this debilitating form of visual impairment. Using modern techniques in human neuroimaging, the proposed study will investigate how changes in the structure (neurite density and cortical thickness) and function (functional connectivity) of visual cortex enable adaptation to central vision loss.

PI_NAMEs: FLEMING, LELAND  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Area;area striata;Behavior Therapy;Behavioral;Blindness;Brain;Brain region;brain remodeling;Categories;Child Abuse and Neglect;density;Deterioration;Development;Disease;experience;extrastriate visual cortex;Face;Human;improved;Individual;insight;Knowledge;Letters;Literature;macula;Macular degeneration;Magnetic Resonance Imaging;Maps;Modernization;Neurites;neuroimaging;Participant;Patients;Performance;Peripheral;Persons;Photoreceptors;Property;public health relevance;Reading;Resolution;Retina;Retinal Diseases;skills;Stimulus;Structure;Techniques;Testing;Therapeutic Intervention;Thick;Vision;Visual;Visual Cortex;Visual Fields;Visual impairment;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Transgenerational Impact of Childhood Maltreatment on Structural/Functional Properties of Visual Cortex


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Ovulation is a critical aspect of female fertility and is controlled by an interplay between neurons within the brain, including those that produce the hormone gonadotropin- releasing hormone (GnRH), and the ovarian hormone estradiol. We are studying this interaction in normal females and how it is disrupted by factors that influence fertility, such as stress. This information can be used to help treat couples facing infertility.

PI_NAMEs: MOENTER, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acute;acute stress;Address;Adrenal Glands;Adult;Affect;Animal Model;Animals;base;biological adaptation to stress;Brain;Cell Nucleus;Cells;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Comprehension;Corticotropin-Releasing Hormone;Couples;Darkness;Electrophysiology (science);Elements;Estradiol;Estrogen Receptors;Estrogens;Estrous Cycle;Exhibits;Experimental Designs;experimental study;Failure;Feedback;Female;female fertility;Fertility;Frequencies;Generations;Genes;Genetic;Goals;Gonadotropin Hormone Releasing Hormone;Homeostasis;Hour;Hypothalamic structure;Individual;Infertility;Investigation;KISS1 gene;Knowledge;Learning;Light;Luteinizing Hormone;Maps;Mediating;Mediator;Modeling;mouse model;Multiple Birth Offspring;Mus;neural;neural network;neurobiological mechanism;Neuroendocrine Cell;Neuroglia;Neurons;Neurosecretory Systems;neurotransmission;operation;Organ;Output;Ovarian;Ovarian hormone;Ovariectomy;Ovary;Ovulation;Pathway interactions;Patients;Pattern;Physiologic pulse;Physiological;Pituitary Gland;Pituitary Hormones;Pituitary-Adrenal System;Process;Proestrus;Property;Psychosocial Stress;receptor;Regulation;Reproduction;reproductive;reproductive function;Reproductive system;Research;response;Role;selective expression;sex;side effect;Signal Transduction;Slice;Steroids;Stress;Stress Tests;Study models;Synapses;Synaptic Transmission;System;Testing;tool;Ventricular;Work

PROJECT_TITLE: Central Actions of Estrogens: Effects on GnRH Neurons

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Dietary Supplements;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Premature infants are vulnerable to undernutrition, which negatively impacts brain growth and development with the potential to permanently impair long-term neurodevelopment. This project seeks to clarify the impact that variability in the intake of a specific micronutrient, zinc, during the neonatal period has on growth, concurrent brain development, and later neurodevelopmental outcomes. The long-term goal of this research is to determine optimal zinc intake among preterm infants and identify nutritional intervention strategies to ensure all infants receive adequate zinc intake to support growth and maximize long-term health outcomes.

PI_NAMEs: BELL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 2 year old;Address;Age;Area;Biochemistry;Birth;Body Composition;Brain;brain magnetic resonance imaging;career;career development;Child;Childhood;Clinical;Cognitive;Confounding Factors (Epidemiology);critical period;Data;Data Correlations;Degree program;Deposition;design;Development;Development Plans;Diet;Dietary intake;Dietary Intervention;Disease;Ensure;Environment;executive function;Exhibits;experience;extreme prematurity;Failure;Fatty acid glycerol esters;Fortification;Foundations;Funding;Future;Goals;Growth;Growth and Development function;Health;high risk infant;Hospitalization;Hospitals;Human Milk;Impairment;improved;infancy;Infant;infant nutrition;innovation;Institution;Intake;Interruption;Intervention;Knowledge;Link;Longitudinal cohort;Macronutrients Nutrition;Malnutrition;Measurement;medical schools;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Micronutrients;Milk;Monitor;Morbidity - disease rate;Motor;Neonatal;Neonatal Intensive Care Units;neonatal period;Neurocognitive;neurodevelopment;Neurodevelopmental Impairment;new technology;novel;Nutrient;nutrition;Nutrition Assessment;Nutritional;Nutritional Science;Nutritional status;Nutritional Support;organ growth;Outcome;patient oriented research;Physicians;Play;Premature Birth;Premature Infant;Preparation;Proteins;Proxy;rapid growth;Recommendation;repository;Research;Research Personnel;Resources;Role;Sampling;Schools;Scientist;skills;Statistical Data Interpretation;success;Supplementation;sustained attention;Testing;Thinness;timeline;Training;training opportunity;United States National Institutes of Health;Weight Gain;white matter;Woman;Work;Zinc;Zinc deficiency

PROJECT_TITLE: The Impact of Zinc Intake on Nutritional Status and Brain Development Among Preterm Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Advanced data analytics is transforming social and behavioral science research on medicine and health. This training program in Computational Social Science will equip a diverse cadre of social and behavioral science health investigators to conduct novel research using advanced computational and statistical methods, preparing them for transdisciplinary careers in data analytics. All aspects of the training will emphasize rigor in research and reproducibility of research results.

PI_NAMEs: BRADSHAW, PATRICK T;HARDING, DAVID JAMES (contact);HAVEMAN, HEATHER

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Social Sciences;Training Programs

PROJECT_TITLE: Computational Social Science Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The InTERACCT Program is a multi-institutional education and training effort that develops and disseminates a web-based curriculum and provides research experiences to prepare a variety of learners with the skills necessary to address health and safety issues that arise in emerging technology workplaces. The program is focusing presently on learning materials related to nanotechnology, additive manufacturing and novel drug delivery.

PI_NAMEs: ARNOLD, SUSAN  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Adoption;animation;Area;Assessment tool;Award;career preparation;Case Study;Characteristics;Chemicals;Competence;Continuing Education;Course Content;course development;Data;Discipline;Drug Delivery Systems;E-learning;Educational Activities;Educational Curriculum;Educational Materials;Educational process of instructing;Emerging Technologies;empowerment;Engineering;Ensure;Exercise;experience;Exposure to;flexibility;Funding;graduate student;hazard;Hazardous Substances;Health;Hour;Hybrids;Hygiene;Individual;Industrial Health;Industrialization;Injury;innovation;Institution;instructor;Interdisciplinary Study;Internet;Iowa;Learning;learning materials;Life;Link;manufacture;mathematical model;Methods;Minnesota;Modeling;Modernization;Monitor;Nanotechnology;Narration;novel;novel therapeutics;Occupational;Occupational Diseases;occupational health/safety;Online Systems;Participant;Persons;Postdoctoral Fellow;prevent;Production;Professional Education;programs;Research;Research Activity;Risk;Risk Assessment;Safety;Science;sensor;skills;Structure;Students;Techniques;Technology;tool;Training;Training Activity;Training and Education;Translating;Universities;Update;Utah;worker safety;Workplace

PROJECT_TITLE: The Interdisciplinary Training, Education and Research Activities for Assessing and Controlling Contaminants from Emerging Technologies (InTERACCT) Program


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Immunotherapy;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: We identified a pathway diverse cancer therapies use to kill cancer cells. Understanding how this pathway works in cancers, how cancers become resistant to these therapies and identifying the proteins that control it will describe a new regulatory pathway that can be leveraged therapeutically and used to extend immunotherapoy to previously untargeted types of cancer.

PI_NAMEs: SHAPIRO, DAVID J (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;Apoptosis Promoter;Autophagocytosis;Brain;Breast Cancer Cell;breast cancer metastasis;Calcium;cancer cell;cancer immunotherapy;cancer therapy;cancer type;Cell Culture Techniques;Cell Death;Cell Death Induction;Cell Death Inhibition;Cell Line;Cell membrane;Cells;Cessation of life;Clinical;Clinical Trials;Colon;Colon Carcinoma;CRISPR screen;Data;Development;Diapause;Disseminated Malignant Neoplasm;drug development;Drug Targeting;Electroporation;Embryo;Endometrial Carcinoma;endoplasmic reticulum stress;ESR1 gene;Estrogens;flexibility;genome-wide;Goals;Immune;Immune checkpoint inhibitor;Immunocompromised Host;immunogenic;immunogenic cell death;Immunotherapeutic agent;Immunotherapy;Knock-out;Knowledge;Link;malignant ascites;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;Mediating;Mediator;Membrane;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Mitochondria;mouse model;Mus;MYC Family Protein;Necrosis;Necrosis Induction;neoantigens;Neoplasm Metastasis;novel anticancer drug;novel therapeutics;Oncolytic;Osmosis;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;protein biomarkers;protein folding;Protein Synthesis Inhibition;Proteins;proteostasis;receptor;Recurrence;Regulatory Pathway;Resistance;resistance mechanism;response;Retreatment;Rupture;sensor;Sodium Channel;Stress;success;Swelling;targeted agent;Testing;Therapeutic;therapeutic target;therapy resistant;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;Tumor Markers;Uterus;virtual;Water;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A Pathway for Necrotic Cell Death

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative For the millions of bilingual parents around the world, and in the US specifically, one of the most pressing questions in the face of the Autism Spectrum Disorder (ASD) diagnosis is how to reconcile it with bilingualism. Yet, little is known about early language development in bilingual toddlers with ASD, and how to best support it. This project examines the development of Spanish and English in young Hispanic and Latine children with ASD, promising to yield immediately practical information to parents, caregivers, and service-providers about how to support dual-language development in this under-represented and under-served population.

PI_NAMEs: KAUSHANSKAYA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Age;Auditory;Autism Diagnosis;autism spectrum disorder;autistic children;bilingualism;Birth;Caregivers;Child;Cognition;Collaborations;Communities;comparison group;cost;Cross-Sectional Studies;Data;Development;Diagnosis;Diagnostic Services;English Language;Environment;Evaluation;experience;Exposure to;Eye;Family;functional outcomes;Future;gaze;Hispanic;Home;innovation;insight;Intervention;Language;Language Development;Language Disorders;language outcome;language processing;Latinx;lexical processing;Linguistics;Longitudinal Studies;longitudinal, prospective study;Maps;Measures;Modeling;novel;Parent-Child Relations;Parents;Participant;Pattern;Population;primary caregiver;programs;Psycholinguistics;recruit;Research;Risk;Role;Sampling;service providers;Services;Severities;sex;Shapes;skills;social communication;Spanish;Spanish/English;Standardization;Stream;Testing;theories;Time;timeline;Toddler;Underrepresented Populations;Underserved Population;visual tracking;Wisconsin;Work

PROJECT_TITLE: Dual Language Development in Young Children with ASD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: OTHERS

ORG_CITY: POMFRET CENTER

ORG_NAME: LIUNA TRAINING AND EDUCATION FUND

ORG_STATE: CT

PHR: Project Narrative The LIUNA Training and Education Fund (LIUNA Training) DOE Worker Training Program provides the education, training and certification needed to build a qualified, safe and efficient workforce that can support current and future nuclear industry needs, including construction, decommissioning, operation, radiation protection, disaster response and waste management jobs. In partnership with its national network of training centers, LIUNA Training provides workers and staff with the knowledge and skill needed to protect themselves, their co-workers, the community, and the environment when working on nuclear energy projects. This is critical to safeguard the health and safety of workers and the public, to maintain the necessary supply of skilled and competent workers and to preserve the integrity of our environmental resources.

PI_NAMEs: LECONCHE, JOHN J. (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TITLE: DOE Hazardous Waste Worker Training Program


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: BURLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Autistic young adults are known to experience social challenges related to dating and sexual relationships that contribute to a significantly increased risk of depression, anxiety, and sexual victimization compared to non- autistic people, and suicide is a leading cause of premature death among autistic adults. Existing sexual education programs for autistic young adults often encourage them to “camouflage” autistic traits by adopting non-autistic social behaviors that are uncomfortable for them, which ultimately exacerbates risks for poor mental health outcomes. In this participatory action project, we will work with autistic self-advocates to identify what specific social challenges autistic young adults face, determine which of those challenges are most problematic for them, and develop a novel dating and sexual education program that teaches autistic young adults skills to navigate social challenges using social strategies that align with their autistic identities.

PI_NAMEs: LEWIS, LAURA FORAN (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Adopted;Adoption;adult with autism spectrum disorder;Advocate;Affect;Age Years;Anxiety;autism spectrum disorder;autism symptoms;autistic;Behavior;Cessation of life;Child;Coitus;Compensation;Conscious;cost;Decision Making;design;Development;Developmental Disabilities;Distress;Education;Educational Materials;Educational process of instructing;Effectiveness;experience;Face;Facial Expression;Fostering;Goals;high risk;improved;individuals with autism spectrum disorder;Instruction;instructor;Intervention;Interview;learned behavior;Learning;Link;member;Mental Depression;Mental Health;Methods;novel;Outcome;Outcome Study;Participant;Pattern;peer;Persons;Pilot Projects;premature;Privatization;Program Description;programs;Psyche structure;Questionnaires;Randomized, Controlled Trials;Research;Research Design;response;Risk;Sex Education;sexual debut;sexual relationship;sexual victimization;skills;social;Social Alienation;Social Behavior;social communication;Social Interaction;social relationships;social situation;social skills;Socialization;Students;Suicide;Surveys;Thinking;Time;Unconscious State;United States;Work;young adult;young adult with autism spectrum disorder

PROJECT_TITLE: Dating and Sexual Education to Address Social Challenges of Autistic Young Adults

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_NAME: EXQOR TECHNOLOGIES, INC.

PHR: The development of a noninvasive, nontoxic nanotechnology for early treatment of AD will provide a major new neuroregenerative tool, which would be able to protect brain structures and restore brain functions in AD more effectively than existing treatment methods, while using lower therapeutic drug doses, and causing fewer side effects. This new nanotechnology will serve as a new neurotrophic/ neuroprotective drug-delivery system that can target relevant brain systems and may also have utility as an imaging agent to enhance diagnosis.

PI_NAMEs: VITALIANO, FRANCO  (contact);VITALIANO, GORDANA D.

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Affect;Aftercare;Age Months;Agonist;Alanine;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animal Disease Models;Animal Model;Animals;Antioxidants;Apoptosis;Aspartate;Biochemical;Biological Markers;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain metabolism;Brain region;brain volume;Brain-Derived Neurotrophic Factor;Bypass;Calcium;Canis familiaris;Cardiology;Cell Physiology;Cell Respiration;Cell Survival;Cells;Choline;Chronic;Clathrin;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Complex;crosslink;cytokine;Data;density;detection method;Development;Diagnosis;Diet;Disease;Dose;Down-Regulation;drug candidate;Drug Carriers;Drug Delivery Systems;Drug Kinetics;Early treatment;Effectiveness;Exercise;FDA approved;Foundations;Free Radicals;Gliosis;Glucocorticoids;Glutamates;Glutathione;Goals;gray matter;Health;Hippocampus;imaging agent;imaging modality;imaging study;Impaired cognition;improved;In Vitro;in vivo;in vivo magnetic resonance spectroscopy;Inflammatory;innovation;Intranasal Administration;intravenous administration;Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;manufacturing scale-up;Maximum Tolerated Dose;Membrane;Memory;Memory impairment;Metabolic;Metabolism;Methods;Microglia;Modality;Molecular;Molecular Target;Monitor;morphometry;mouse model;Mus;myoinositol;N-Methylaspartate;nanoparticle;nanoparticle delivery;Nanotechnology;nanotechnology platform;Natural regeneration;Nerve Degeneration;Nerve Regeneration;neurobehavioral;neurogenesis;neuroimaging;neuron loss;neuronal metabolism;Neuronal Plasticity;Neurons;Neuroprotective Agents;neuropsychiatry;neurorestoration;neurotoxic;neurotrophic factor;next generation;non-invasive imaging;Nose;novel;Oral;Organ;Oxidative Stress;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Placebos;Positron-Emission Tomography;pre-Investigational New Drug meeting;prevent;Production;Proteins;Protons;radiotracer;Rattus;Recovery;Reporting;Research;Research Project Grants;Resolution;Safety;safety study;Saline;Scanning;Schedule;Series;side effect;Signal Pathway;Signal Transduction;Small Business Innovation Research Grant;small molecule;socioeconomics;Structure;Synapses;synaptogenesis;System;tau aggregation;tau Proteins;Testing;Therapeutic;Therapeutic Agents;Therapeutic Uses;tool;Toxic effect;Toxicology

PROJECT_TITLE: New BDNF Nanoparticles for Early Treatment of Alzheimer's Disease


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The objective of this project is to develop a new technology with which to identify the healthiest embryos for IVF implantation. This will increase success rates, reduce multiple pregnancies and abortions, and yield healthier offspring generated by IVF procedures.

PI_NAMEs: ABATE, ADAM R. (contact)

PROJECT_TERMS: Abate;abortion;Address;Adult;Affect;American;assisted reproduction;Awareness;Beta Cell;Biological Sciences;Biomedical Engineering;Biomedical Research;Biosensing Techniques;Biosensor;Birth;cancer cell;care costs;Cell Therapy;Chemicals;Clinic;Clinical;commercialization;Complex;cost effective;Country;Culture Media;Data;Denmark;design;Development;Diabetes Mellitus;Diagnostic;diagnostic value;DNA;Drops;Embryo;embryo culture;Embryo Transfer;Endocrinologist;Engineering;Ensure;Environment;Epigenetic Process;Exhibits;experience;Exposure to;extracellular;Fertility;Fetus;Foundations;Frequencies;Functional disorder;Future;gene therapy;Genomics;Glucose Intolerance;Goals;Grant;Health;Health Care Costs;Health Technology;Human;Hydrogels;Hypertension;Impaired health;Implant;implantation;improved;Individual;invention;Japan;Lipids;Marketing;Maternal Health;Measurement;Measures;Metabolic;Metabolic dysfunction;Metabolism;meter;Methods;Microfluidics;Mission;Mitochondria;Modification;Molecular;Morphology;Mothers;mouse model;Multiple Birth Offspring;Multiple Pregnancy;Mus;Nanotechnology;National Institute of Child Health and Human Development;natural Blastocyst Implantation;neonatal health;new technology;novel;offspring;Oncology;operation;Outcome;oxidation;Oxidative Stress;particle;Physicians;Placentation;Predictive Value;Pregnancy;Pregnancy Rate;preimplantation;Procedures;Proteins;prototype;Regulation;Reporting;reproductive;Reproductive Health;Research;Risk;Sampling;Science;screening;sensor;Services;skills;Stress;stress reduction;success;Techniques;Technology;temporal measurement;Testing;Translating;Translations;Uterus;Variant;Woman;Work

PROJECT_TITLE: A non-invasive metabolic sensor for improving success in IVF

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Early life sleep disruption has been associated with changes in prefrontal cortical development and social behavior later in life, in both individuals with autism spectrum disorder and in a unique wild rodent model of social affiliation/attachment, the prairie vole. Here we propose to both map the trajectory of behavioral changes from life to adulthood in this model and to measure medial prefrontal electrophysiologic correlates of changes in affiliation/attachment behavior. We also propose to reverse this early life-induced autism-like behavior using optogenetics with the goal of elucidating both mechanistic and therapeutic targets

PI_NAMEs: LIM, MIRANDA M;WATSON, BRENDON O (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Animals;autism spectrum disorder;autistic children;Behavior;Behavioral;behavioral phenotyping;Biological Models;Brain;Climacteric;comparison control;Cues;Custom;Dendritic Spines;Development;Electrophysiology (science);Equilibrium;Event;experimental study;Exposure to;Foundations;Frequencies;Future;Goals;Home;Human;Individual Differences;individuals with autism spectrum disorder;Infant;Intervention;Knowledge;late life;Life;Machine Learning;Maps;Measures;Medial;Microtus;Modeling;Molecular;Monitor;Mus;novel;Nucleus Accumbens;optogenetics;Partner in relationship;Phase;Phenotype;postnatal;prairie vole;preference;Prefrontal Cortex;pup;Rattus;Reporting;Research Domain Criteria;Resolution;response;Rodent;Rodent Model;Same-sex;sex;Shapes;Siblings;Sleep;Sleep disturbances;social;social attachment;Social Behavior;social deficits;Social Interaction;Structure;Testing;therapeutic target;Time;tool;Variant;Work

PROJECT_TITLE: Effects of early life sleep disruption on prefrontal cortex electrophysiological state and affiliation/attachment


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE By promoting multidisciplinary team science, fully engaging institutional and community stakeholders in the design and implementation of health research, accounting for adverse aspects of the “sociome” – that is, the social, environmental, behavioral, and psychological factors through which structural racism impairs health – and developing innovative and sometimes disruptive approaches to advance the science and practice of clinical and translational research, we expect to mitigate disease risk, morbidity and mortality, improve the conduct and pace of health research, and ultimately improve the health – and health equity – of Chicago and the nation.

PI_NAMEs: JACOBS, JOSHUA J;MELTZER, DAVID O (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Accounting;Acute Pain;Address;Advocate;Behavioral;Biological;biological systems;Chicago;Chronic;Clinical Data;clinical practice;Clinical Research;Clinical Sciences;Clinical Treatment;Clinical Trials Network;Communication;Communities;Comprehensive Health Care;Conceptions;cost;COVID-19 patient;Data;data resource;de novo mutation;design;Disease;disorder risk;Diverse Workforce;Drug abuse;Ecosystem;Equity;Ethics;food insecurity;Funding;genomic data;Goals;Health;health equity;Health Personnel;Health system;Healthcare;Helmet;Home;Human;Human Biology;Illinois;Image;Impaired health;improved;improved outcome;Individual;Informatics;Infrastructure;Injury;innovation;Institution;Intervention;Investments;Joints;Knowledge;lens;life span;Lived experience;Malignant Childhood Neoplasm;Mechanical ventilation;Medical Imaging;Methods;metropolitan;Modeling;Morbidity - disease rate;mortality;multidisciplinary;pandemic disease;Patients;Phase;Physicians;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;programs;Psychological Factors;Research;Research Personnel;Research Training;Resources;Role;Science;Scientist;social;social determinants;Societies;somatosensory;Source;Special Population;Structural Racism;System;Technology;Testing;tool;Training;translational medicine;Translational Research;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: The Institute for Translational Medicine


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: HIV and TB remain high among the top ten causes of death in low-income countries. Given the budgetary constraints to conduct the array of ongoing and potential clinical trials, we have developed a Value of Information (VOI) framework to assess a priori which trials might provide the best value, formally comparing courses of action with and without new information – as might be obtained from a trial – to quantify the value of information acquisition, accounting for both the trial benefits and costs.

PI_NAMEs: REDDY, KRISHNA P (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Antibodies;antiretroviral therapy;Area;Cause of Death;Clinical Trials;Clinical Trials Design;Collaborations;cost effectiveness;Costs and Benefits;design;Development;diagnostic strategy;Evaluation;HIV/TB;information framework;Instruction;International;low income country;Mediating;Methodology;Methods;Modeling;Monte Carlo Method;novel;Policies;prevent;Prevention;Productivity;Reporting;Resources;Sampling;Science;South Africa;treatment strategy;tuberculosis diagnostics;vaccination strategy;Vaccines

PROJECT_TITLE: Novel Methods to Inform HIV/TB Clinical Trial Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

PHR: Oral candidiasis, also known as oral thrush, is an AIDS-defining fungal infection of the oral mucosa that afflicts individuals on chemotherapy, transplant patients taking immunosuppressive drugs, asthma patients using inhaled corticosteroid drugs or others with compromised immune function such as infants and the elderly. The objective of this project is to understand interactions between Candida albicans and the host immune system, with a focus on cells of the oral epithelium. The long-term goal of this research is to develop better therapies or vaccines for mucosal disease of the oral cavity, and to understand the consequences of therapies that suppress specific immune events.

PI_NAMEs: GAFFEN, SARAH L (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adaptive Immune System;Adrenal Cortex Hormones;anti-fungal agents;anti-microbial peptide;Area;asthmatic patient;Automobile Driving;Candida albicans;Candidiasis;CCAAT-Enhancer-Binding Proteins;Cell Communication;Cell Compartmentation;Cell Differentiation process;Cell membrane;Cell Proliferation;cell type;Cells;chemokine;chemotherapy;Client;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Data Set;Disease;draining lymph node;Elderly;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial repair;Epithelium;Event;Family;Family member;Funding;fungus;Goals;Grant;Homeostasis;Host Defense;Human;Hyphae;IL17 gene;Immune;immune function;Immune response;Immune system;Immunity;immunodeficiency;Immunology;Immunosuppressive Agents;Individual;Infant;Infection;Inhalation;Innate Immune System;interest;Interleukin-1;interleukin-22;interleukin-23;Laboratories;Lead;Location;Lymphocyte;MAP Kinase Gene;Mediating;Microbe;model organism;Molecular;Morphology;Mouth Diseases;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Mycoses;Neutrophil Infiltration;NF-kappa B;Oral;Oral candidiasis;Oral cavity;oral cavity epithelium;oral immunity;oral infection;Oral mucous membrane structure;oral pathogen;oral tissue;oropharyngeal thrush;p38 Mitogen Activated Protein Kinase;pathogen;pathogenic fungus;Pathway interactions;Peptides;Permeability;Pharmaceutical Preparations;posttranscriptional;Production;Property;Regulation;Reporting;Research;response;RNA Stability;RNA-Binding Proteins;Signal Induction;Signal Pathway;Signal Transduction;Signal Transduction Induction;single-cell RNA sequencing;Site;Source;STAT3 gene;stem;Stromal Cells;System;T cell response;T-Lymphocyte;TIS11 protein;tissue regeneration;tissue repair;Tissues;Toxin;trait;Transcript;transcription factor;Translations;Transplant Recipients;Up-Regulation;Virulence;Virulence Factors;Work

PROJECT_TITLE: Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative This proposal aims to launch a Consortium Coordinating Center to serve the goals of facilitating communication between Social, Behavioral, and Economic Research on COVID-19, facilitating collaboration within and across the funded U01 projects, associated NIH Centers, and disseminating research advances, activities, and resources to a broad audience of stakeholders. Through these efforts, the Consortium Coordinating Center significantly magnifies the impact of SBE activities and findings.

PI_NAMEs: KUBALE, JOHN  (contact);LEVENSTEIN, MARGARET CATHERINE

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Access to Information;Address;Area;Behavioral;behavioral and social science;Behavioral Sciences;Black American;Collaborations;Communication;Communities;Complex;COVID-19;Data;data resource;Data Science;data sharing;Development;Disasters;Economics;Fostering;Funding;Generations;Goals;Growth;Health;health disparity;health equity;Information Distribution;information model;Infrastructure;innovation;Interdisciplinary Study;International;Investments;Longitudinal Studies;meetings;Methods;Michigan;Mission;Modality;Modeling;open data;Pilot Projects;Play;podcast;Policies;Policy Maker;Politics;population based;population health;Productivity;programs;Publications;Reporting;Research;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Role;Running;social;social health determinants;Social Sciences;Statistical Data Interpretation;Surveys;Training;United States National Institutes of Health;Universities;Vulnerable Populations;web site;webinar;Work;working group

PROJECT_TITLE: Consortium Coordinating Center for Social, Behavioral, and Economic Research on COVID-19


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The innate immune sensor NLRP3 responds to environmental and infectious triggers, and can promote acute and chronic inflammatory disease, causing organ dysfunction. NLRP3 activation in myeloid cells is important in many diseases but the roles of specific myeloid cell types remains unclear. This study investigates a dominant role of neutrophils and their precursors in NLRP3-dependent autoinflammation in mouse and human cells.

PI_NAMEs: CROKER, BEN ADAM (contact);HOFFMAN, HAROLD M

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Abnormal Neutrophil;Acute;autoinflammation;automated image analysis;autosome;Biochemical;Blood;CASP1 gene;Caspase;Cell Differentiation process;Cell Lineage;cell type;Cells;Central Nervous System;Chronic;chronic inflammatory disease;clinical translation;CSF3 gene;cytokine;Data;design;Development;Diagnosis;Disease;Disease Management;Emergency Situation;Enzyme-Linked Immunosorbent Assay;Fetal Liver;Functional disorder;gain of function mutation;Generations;Genetic;Granulopoiesis;Human;IL18 gene;Immune;improved;in vivo;Inflammasome;Inflammation;Inflammatory;Interleukin-1;Interleukin-6;life span;live cell imaging;Macrophage;Modeling;Molecular;monocyte;Morbidity - disease rate;mouse model;Mus;Musculoskeletal System;Mutation;Myeloid Cells;Natural Immunity;Neonatal;neonatal mice;neonate;neutrophil;novel marker;Organ;Pathogenesis;Pathology;Patients;Periodicals;Pharmaceutical Preparations;Phenocopy;Population;positional cloning;Process;Production;progenitor;Proliferating;Regimen;Regulation;Reporting;Research;Role;sensor;Serum;Shapes;Signal Transduction;Skin;Sorting;Source;Stimulus;Symptoms;Syndrome;targeted treatment;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;translational therapeutics;Western Blotting

PROJECT_TITLE: The Neutrophil Lineage in Inflammasomopathies

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  The University of Kansas Alzheimer's Disease Research Center's T32 training grant Multidisciplinary Research Training Program in Alzheimer's Disease and Related Disorders is designed to enhance research training opportunities for Alzheimer's disease (AD), AD related disorders (ADRD), and brain aging. The collaborative, multidisciplinary research training program will accelerate training of the next generation of scientists needed to find treatments for Alzheimer disease and other dementias.

PI_NAMEs: BILLINGER, SANDRA A;VIDONI, ERIC DENNIS (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's disease related dementia;Interdisciplinary Study;Training Programs


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Heart Disease;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The strategy to prevent acute kidney injury (AKI) and its progression relies on clinical interventions provided as a care-bundle to minimize injury to the kidneys. This care-bundle, however, lacks the ability to personalize care for patients. This project will use novel machine learning methods to determine a personalized strategy for prevention of persistent AKI after cardiac surgery.

PI_NAMEs: SAKHUJA, ANKIT  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Award;Blood Pressure;Cardiac Surgery procedures;career development;Caring;Characteristics;Clinic;Clinical;Clinical Decision Support Systems;clinical decision-making;collaborative environment;Creatinine;Critical Care;Data;data mining;Data Science;Development;Development Plans;Dialysis procedure;Digital biomarker;early detection biomarkers;empowerment;Ensure;Evolution;experience;Feedback;Foundations;Goals;high risk;Hour;Hyperglycemia;improved;improved outcome;Incidence;Injury to Kidney;Intensive Care Units;Intervention;Kidney Diseases;Leadership;Learning;learning algorithm;Liquid substance;Machine Learning;machine learning algorithm;machine learning method;Measures;Medicine;Mentors;Methodology;mortality;mortality risk;Nephrology;novel;Operative Surgical Procedures;Outcome;Patient Care;Patients;personalized approach;personalized care;personalized decision;personalized medicine;personalized strategies;Pharmaceutical Preparations;Phenotype;predictive marker;prevent;Prevention;Prevention strategy;programs;Psychological reinforcement;Public Health Informatics;Research;Research Personnel;Rest;Risk;Serum;skills;Structure;supervised learning;Time;tool;Training;treatment response;treatment strategy;United States National Institutes of Health;Universities;West Virginia;Work

PROJECT_TITLE: Using Novel Machine Learning Methods to Personalize Strategies for Prevention of Persistent AKI after Cardiac Surgery

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Glioblastoma (GBM) is the most common and lethal type of primary brain tumor that is highly resistant to current treatments, indicating that development of new effective therapeutic approaches is urgently needed. Because both glioma stem cells (GSCs) and the tumor-promoting macrophages (pTAMs, M2) promotes malignant growth and therapeutic resistance, synergistically targeting GSCs and reprograming pTAMs into tumor-suppressive macrophages (sTAMs, M1) may significantly improve GBM treatment. In this proposal, we will assess whether redirecting pTAMs into sTAMs through BACE1 inhibition by MK-8931 in combination with targeting GSCs through BMX inhibition by ibrutinib can serve as a novel strategy to significantly improve GBM treatment.

PI_NAMEs: BAO, SHIDENG  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Alzheimer's Disease;beta-site APP cleaving enzyme 1;Biological Assay;blood-brain barrier penetration;blood-brain tumor barrier;BMX gene;cancer cell;Cell Maintenance;Cells;Clinical Trials;cytokine;design;Development;Dose;drug candidate;Future;Glioblastoma;Glioma;Growth;Human;human induced pluripotent stem cells;Immunosuppression;Impairment;improved;Infiltration;inhibitor;Label;Low Dose Radiation;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;Molecular Target;Mus;Nature;neoplastic cell;novel strategies;novel therapeutic intervention;Outcome;Pericytes;Phagocytosis;pharmacologic;Play;preclinical study;Primary Brain Neoplasms;Prognosis;programs;Protein Tyrosine Kinase;radiation resistance;Resistance;Role;safe patient;screening;small molecule;STAT3 gene;stem cell self renewal;stem cells;synergism;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy resistant;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumorigenic;Vascular Permeabilities;Xenograft procedure

PROJECT_TITLE: Reprograming Macrophages and Targeting Glioma Stem Cells in Glioblastoma


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Hematology;Infectious Diseases;Lung;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Acute respiratory distress syndrome (ARDS) is common and deadly, and no specific medicines treat ARDS. The Meyer research program aims to overcome this lack of therapy by leveraging a robust human molecular cohort study of sepsis, the most common cause of ARDS, and applying genomic tools with deep immune phenotyping to uncover specific patterns of response that may respond to unique treatments. Our goals are to explain individualized ARDS risk, highlight specific patterns of immune response, and test how patterns change over time and with treatment.

PI_NAMEs: MEYER, NUALA JENNINGS (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Address;Admission activity;American;Area;Bacteremia;biomedical informatics;Body System;career development;Cessation of life;Clinical;Cognitive;cohort;Cohort Studies;COVID-19 pandemic;COVID-19/ARDS;Critical Illness;Data;Delirium;DNA;Fostering;Functional disorder;Funding;Genetic;genomic tools;Genomics;Goals;Health;Human;human subject;Immune;Immune response;improved;Individual;individualized medicine;Inherited;Injury;Intensive Care;Intensive Care Units;Investigation;Investments;Knowledge;lung health;Medicine;Mentorship;metabolomics;Molecular;mortality;National Heart, Lung, and Blood Institute;Organ failure;organ injury;Outcome;Pathway interactions;patient oriented;Patients;Pattern;personalized medicine;Pharmacological Treatment;Phenotype;Plasma;predicting response;Predisposition;Prevention;programs;Proteins;Proteomics;Quantitative Trait Loci;Recovery;Research;Research Personnel;Resolution;response;Risk;RNA;Sepsis;sepsis induced ARDS;Shock;Sterility;Syndrome;T-Cell Activation;Techniques;Testing;Time;Training;trait;transcriptomics;Translational Research;translational research program;Viremia;Visualization;whole genome

PROJECT_TITLE: Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress Syndrome


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Women living with HIV are at increased risk for preterm birth and have altered vaginal bacterial communities. Here we will test the hypothesis that HIV infection leads to an expanded vaginal virome, which either directly or indirectly (through alteration of the bacterial microbiota) is associated with a higher preterm birth risk. Understanding the interplay between HIV, antiretrovirals, vaginal viruses, bacteria and risk of preterm birth is relevant for developing novel diagnostics and interventions for improving birth outcomes among pregnant women living with HIV, and ultimately to decrease infant morbidity and mortality.

PI_NAMEs: JASPAN, HEATHER BERYL (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adenoviruses;Adjuvant;adverse birth outcomes;Adverse event;Africa South of the Sahara;African Women;Age;American;Anti-Retroviral Agents;Anti-viral Therapy;Antibiotics;antiretroviral therapy;Bacteria;bacterial community;Bacterial Vaginosis;bacteriome;Bacteriophages;Base Sequence;Birth;CD4 Positive T Lymphocytes;Cell Count;Cells;Cervical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Cohort Studies;Communities;cytokine;Data;Development;Disease;Enteral;Eukaryota;experience;Family;female reproductive tract;genetic signature;Genome;Genotype;Gestational Age;Herpesviridae;High Prevalence;high risk;High Risk Woman;HIV;HIV Infections;Human papilloma virus infection;Human Papillomavirus;Immune;improved;In Vitro;infant morbidity;infant morbidity/mortality;Inflammation;Infrastructure;Intervention;Link;Maternal Age;maternal morbidity;Measures;metagenomic sequencing;microbiota;MicroRNAs;Modeling;Morphology;novel diagnostics;Nucleic acid sequencing;Outcome;Papillomavirus;parity;particle;Peripheral;Persons;Pharmaceutical Preparations;Play;point of care testing;Postpartum Period;pre-exposure prophylaxis;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Prokaryotic Cells;reproductive tract;Risk;Risk Factors;risk mitigation;Role;Sampling;Shotguns;South Africa;South African;Testing;Therapeutic;Vagina;vaginal microbiota;vector vaccine;Viral;virome;Virus;virus host interaction;virus identification;Woman

PROJECT_TITLE: Influence of HIV infection on vaginal virome and risk of preterm birth in pregnant South African women

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Immunotherapy;Lymphatic Research;Rheumatoid Arthritis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Rheumatoid arthritis (RA) is the most prevalent autoimmune disease, which affects ~1% of our population, and is largely manifested by episodic flares of joint inflammation, pain and tissue destruction. Based on our findings in mice, and RA patients, we discovered that arthritic flare can be caused by the loss of lymphatic drainage from the affected joint, and that known drugs that can increase lymphatic drainage may be affective therapies to treat RA flair. Here we propose to test this theory in mouse models and RA patients.

PI_NAMEs: SCHWARZ, EDWARD M. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acute;Adherence;Adoptive Transfer;Adult;Affect;Affective;aggressive therapy;Animals;anti-CD20;Anti-Tumor Necrosis Factor Therapy;Apoptotic;Arthritis;arthropathies;Autoimmune Diseases;B cell therapy;B-Lymphocytes;Biological Markers;Biological Response Modifier Therapy;Blood Vessels;Bromodeoxyuridine;cell injury;Cell Maintenance;Cells;Characteristics;Chronic;Clinical;clinically significant;collagen antibody induced arthritis;Data;Defect;Diagnosis;Disease;draining lymph node;early onset;Etiology;experience;Failure;Flare;Frequencies;Functional disorder;functional genomics;Funding;Genetic;Grant;Growth;Hand;hand therapy;Homeostasis;human disease;Image;imaging biomarker;Immune response;improved;In Vitro;in vivo;Indocyanine Green;Inflammation;Inflammatory;Inflammatory Arthritis;insight;Investigation;Ipsilateral;ITGAM gene;joint inflammation;Joints;Knee;Label;loss of function;LoxP-flanked allele;Lymph;lymph flow;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;lymphatic vessel;Lymphocyte;Macrophage;Maintenance;Mediating;Messenger RNA;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Muscle Cells;muscle progenitor cell;Myeloid Cells;Nature;Near-infrared optical imaging;new therapeutic target;novel;Outcome;Pain;Pathway interactions;Patients;PDGFB gene;PDGFRB gene;Peer Review;Pharmaceutical Preparations;Phase;PIK3CG gene;Placebos;Population;prevent;progenitor;Publications;Recovery;Recovery of Function;recruit;Recurrent disease;Refractory;Refractory Disease;repaired;Rheumatoid Arthritis;Role;Secondary to;Signal Transduction;Signs and Symptoms;single-cell RNA sequencing;Sinus;Swelling;Synovitis;targeted treatment;Testing;theories;Tissues;TNF gene;translational research program;treatment response

PROJECT_TITLE: Elucidating the Mechanisms of Arthritic Flare and Developing Treatments

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Primary Immunodeficiencies;Rare Diseases;Social Determinants of Health

ORG_CITY: LEWISTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: LEWIS-CLARK STATE COLLEGE

ORG_STATE: ID

PHR: The DNA in our cells is continually at risk of damage that can adversely affect health and disease. The overall goal of this project is to investigate how the Bloom (BLM) DNA helicase prevents damage caused by the presence of difficult-to-replicate repetitive DNA sequences. We will use the model organism Drosophila melanogaster, the fruit fly, and genetic and molecular biology tools to better understand how a lack of BLM protein in human patients leads to the developmental abnormalities, premature aging, and cancer susceptibility seen in Bloom Syndrome.

PI_NAMEs: STOFFREGEN, ERIC PAUL (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Address;Affect;Aging;autosome;Biological;Biomedical Research;biomedical scientist;Bloom Syndrome;Bloom syndrome protein;Body Composition;Body Size;Cell Cycle;Cell Physiology;Cells;college;Complex;Creativeness;Data;demographics;Development;Discipline;Disease;Disproportionately impacts women;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA replication fork;DNA Replication Induction;DNA Sequence;Drosophila genome;Drosophila genus;Drosophila melanogaster;Elements;Eligibility Determination;Embryo;Embryonic Development;Family;Female;Fertility;First Generation College Students;fly;Future;Genetic;Genetic Determinism;Genome;genome integrity;genome sequencing;Genomic DNA;Goals;Grant;hatching;Health;Health Professional;helicase;Heterozygote;Human;Human Genome;Individual;Institution;life span;Link;Long-Term Effects;Malignant Neoplasms;Maps;Measurable;member;Minority Groups;model organism;Molecular Biology;Motor Activity;Nuclear Proteins;Patients;Phenotype;Physiological;Play;Ploidies;Population;Predisposition;Premature aging syndrome;preservation;prevent;programs;Prokaryotic Cells;Proteins;recruit;Repetitive Sequence;replication stress;Reporting;Research;Research Training;response;Risk;Role;Rural;Severities;Sex Bias;socioeconomics;Source;student training;Students;Study models;Survivors;Syndrome;Taxes;tool;undergraduate research;undergraduate student;university student;Variant;whole genome;Y Chromosome

PROJECT_TITLE: Causes and consequences of Blm-dependent DNA replication challenges


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: 8. Project Narrative: Mutations in the mitochondrial genome (mtDNA) are observed in many cancers, but the role of these mutations in shaping cellular metabolism and tumor growth is incompletely understood. Here, we study a disease outlier, Hürthle cell thyroid carcinoma (HTC), in which mtDNA mutations are highly enriched to study the cause and consequences of electron transport chain (ETC) dysfunction in cancer. These findings will be extended to other forms of thyroid and kidney cancer that harbor mtDNA mutations and be of immediate and direct relevance to patients with HTC and have broad implications across cancer types by providing new insights into ETC function in cancer.

PI_NAMEs: MCFADDEN, DAVID GLENN (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Aerobic;Alleles;anaplastic thyroid cancer;Biological Models;Cancer Patient;cancer type;Carbon;Cell Line;Cells;Clinical;Clinical Protocols;Complex;CRISPR screen;Data;Defect;Dependence;Disease;Electron Transport;Environment;Enzymes;Evaluation;Event;exome sequencing;Fermentation;Fresh Tissue;Functional disorder;Genetic;Genetically Engineered Mouse;Genotype;Glucose;Glycolysis;Goals;Histology;Human;Immunocompetent;Impairment;Infusion procedures;inhibitor;insight;Isotopes;Knowledge;Label;Lactate Dehydrogenase;loss of function;Malignant neoplasm of thyroid;Malignant Neoplasms;Metabolic;metabolic phenotype;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial DNA mutation;mitochondrial genome;Modeling;Monitor;Mus;mutant;Mutation;NADH dehydrogenase (ubiquinone);neoplastic;novel;Nuclear;Operative Surgical Procedures;Papillary thyroid carcinoma;participant enrollment;patient derived xenograft model;patient subsets;Patients;preclinical evaluation;preclinical study;Proliferating;Regulation;Renal Carcinoma;Resistance;Respiration;response;restoration;Role;Shapes;small molecule inhibitor;small molecule therapeutics;stable isotope;synthetic lethal interaction;Therapeutic;therapeutic target;Therapeutic Uses;Thyroid Gland;Thyroid Hurthle Cell Carcinoma;thyroid neoplasm;Tissues;Trace Elements Nutrition;treatment response;tumor;tumor growth;tumor metabolism;tumorigenesis;University Hospitals;Variant;whole genome;Xenograft Model

PROJECT_TITLE: Identifying metabolic dependencies in Hurthle cell carcinoma of the thyroid-Res 1

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Project Narrative The overarching goal of this study is to determine whether effective treatment of hypertension impacts brain blood flow, amyloid, and tau, hallmarks of Alzheimer’s disease (AD), in older adults who are at high risk of dementia. Furthermore, we will determine the impact of hypertension treatment on brain white mater integrity and neural network connectivity and their relationship to brain amyloid and tau deposition. The new knowledge obtained is potentially important for development of multidomain strategies for dementia prevention and treatment.

PI_NAMEs: VONGPATANASIN, WANPEN ;ZHANG, RONG  (contact);ZHU, DAVID C

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta accumulation;Abeta clearance;Adult;Age;aged;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;arm;arterial stiffness;Biological;Biological Process;blood oxygen level dependent;Blood Pressure;blood pressure medication;blood-based biomarker;Brain;Cardiovascular Diseases;Cerebral small vessel disease;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Dementia;dementia risk;Deposition;Development;effective therapy;Enrollment;Etiology;Family history of;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;glymphatic system;Goals;Healthcare;high risk;human old age (65+);Hypertension;hypertension treatment;Impaired cognition;improved;Incidence;indexing;Injury;insight;Intervention;Isolated systolic hypertension;Knowledge;late life;Magnetic Resonance Imaging;Measures;Memory;Meta-Analysis;middle age;National Institute on Aging;neural network;Neurocognitive;neuroimaging;neuropathology;older adult;Outcome;Participant;Pathogenesis;Pathology;Perfusion;Pharmacologic Substance;Positron-Emission Tomography;prevent;Prevention;Randomized;Regulation;Research;Rest;Risk;Risk Factors;Risk Marker;Risk Reduction;Rodent;Role;Signal Transduction;Societies;Stroke;tau Proteins;treatment as usual;white matter;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study)


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Nutrition;Osteoporosis;Physical Activity;Prevention

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Ketogenic diet is popular for weight management and may help treat neurological disorders, but it may also cause severe bone loss that increases fracture risk. This project contributes to public health by characterizing the effect of ketogenic diet on bone strength throughout adulthood, if KD prevents exercise from increasing bone strength, and investigating if ketone bodies are a primary mechanism driving bone loss. In the long term, the findings can improve understanding of how ketogenic diet contributes to fracture risk and the development of therapies to prevent bone loss on a ketogenic diet.

PI_NAMEs: OSIPOV, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Advisory Committees;Affect;Age;age difference;age effect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;animal old age;Animals;Automobile Driving;Behavior;beta-Hydroxybutyrate;Biological;Body Weight decreased;bone;bone cell;bone health;bone loss;bone mass;Bone Matrix;Bone remodeling;Bone Resorption;bone strength;Bone structure;Bone Tissue;bone turnover;C14 isotope;Carbohydrates;career;Chemicals;Child;Clinical;Clinical Research;clinically significant;Cognitive aging;cytokine;Diet;diet and exercise;dietary control;Educational workshop;Elements;Epilepsy;Equipment;Esters;Exercise;Faculty;Fatty acid glycerol esters;Fellowship;fracture risk;Gene Expression;Gene Expression Regulation;Health;High Fat Diet;Hormones;Human;human old age (65+);improved;Inflammation;innovation;Insulin-Like Growth Factor I;Interdisciplinary Study;interest;Intervention;Intractable Epilepsy;K-Series Research Career Programs;ketogenic diet;Ketone Bodies;Ketones;Knock-out;Knowledge;Label;Laboratories;Life;life span;Ligands;Link;Location;mature animal;Measures;mechanical properties;Mechanical Stimulation;Mediating;Metabolism;middle age;Molecular Biology;mouse model;Mus;Muscle;Nervous System Disorder;Neurologic;Nicotinic Acids;old mice;Organ;Osteoblasts;Osteoclasts;osteogenic;Parkinson Disease;Pathway interactions;Persons;Play;Population;pre-clinical;prevent;Process;Protein Biosynthesis;PTH gene;Public Health;receptor;Recovery;reduce symptoms;Reducing diet;Research;Research Personnel;response;Role;Route;Serum;Signal Transduction;skeletal;Skeletal system;skills;slow potential;Stroke;Structure;Students;Supplementation;Tendon structure;Testing;Therapeutic;therapy development;Time;Training;training opportunity;treadmill;Up-Regulation;Vitamin D;Weight maintenance regimen;young adult

PROJECT_TITLE: Age Differences and Mechanisms of Ketogenic Diet Induced Bone Loss

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE. The UPMC Clinical Center for the Study of Diabetes after Acute Pancreatitis (UPMC CC) is a multidisciplinary research program at the University of Pittsburgh and UPMC. Collaborative studies are proposed which will lay the groundwork for evaluation, management and treatment of diabetes caused by acute pancreatitis. UPMC CC’s world-class faculty, extensive clinical resources, high patient volumes, clinical and translational research experience, participation and leadership in multicenter studies and consortiums, and record of accomplishments will ensure the success and effectiveness of the Type 1 Diabetes in Acute Pancreatitis Consortium.

PI_NAMEs: TOLEDO, FREDERICO G. S.;YADAV, DHIRAJ  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acceleration;Acute;acute pancreatitis;Address;Adult;American;Antibodies;Antigens;Area;Autoantibodies;Autoantigens;Autoimmunity;Beta Cell;Biological Markers;Cell Physiology;Characteristics;chronic pancreatitis;Clinical;clinical center;clinical infrastructure;Clinical Research;cohort;Collaborations;Complication;Data;data exchange;data management;design;Diabetes Mellitus;diabetes pathogenesis;diabetic patient;Disease;Effectiveness;Endocrine;Enrollment;Ensure;Epidemiology;Etiology;Evaluation;Exocrine pancreas;experience;Faculty;follow-up;Foundations;Functional disorder;Funding;Hospitals;Incidence;Individual;Inflammation;Infrastructure;Injury;Insulin;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;Knowledge;Leadership;Measures;member;Metabolic;Monophenol Monooxygenase;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-diabetic;Nursing Faculty;Observational Study;OGTT;organizational structure;Pancreas;Pancreatic Diseases;Pancreatitis;Participant;Patients;personalized medicine;Phosphoric Monoester Hydrolases;Prediabetes syndrome;predictive marker;Predisposition;prevent;programs;prospective;Proteins;Random Allocation;Recovery;recruit;Recurrence;Relative Risks;Research;research faculty;Research Infrastructure;Resolution;Resources;Risk;Sampling;Schedule;secondary endpoint;Serum;Severities;Solid;stem;success;Testing;Time;Translational Research;translational study;Universities;Visit;Work;zinc-binding protein

PROJECT_TITLE: UPMC Clinical Center for the Study of Diabetes After Acute Pancreatitis


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Microbiome;Sexually Transmitted Infections

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project explores the important question of how oral and gut microbes interact during HIV infection, and how these interactions may alter the immune environment in the mouth leading to inflammation and susceptibility to oral sexually transmitted infections (STIs). We will use longitudinal oral and gut microbiome profiling plus saliva antibody measures to investigate mechanisms leading to inflammation in HIV, and apply machine learning to identify microbiome signatures of STI risk. Results from this study could aid in developing novel strategies and saliva-based monitoring tools to better treat HIV and reduce comorbidities.

PI_NAMEs: FULCHER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acceleration;Address;Age;Antibodies;antiretroviral therapy;Automobile Driving;Bacteria;Bacterial Translocation;Binding;Cardiovascular Diseases;Chlamydia trachomatis;Chronic;Clinical;clinical epidemiology;co-infection;cohort;comorbidity;Complex;cytokine;Data;Development;Disease;Disease Progression;dysbiosis;Environment;Fc Receptor;Functional disorder;gut bacteria;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;Health;HIV;HIV Infections;HIV-1;HIV/AIDS;Human papilloma virus infection;Immune;immune activation;Immune Sera;Immunoglobulin A;Immunologic Markers;improved;in vitro Assay;Infection;infection risk;Inflammation;Inflammatory;inflammatory marker;interest;Link;Literature;longitudinal analysis;Machine Learning;Measures;metagenomic sequencing;Microbe;microbial;microbiome;microbiome composition;microbiome signature;migration;Monitor;monomer;Mucosal Immune System;Mucosal Immunity;mucosal site;Mucositis;Mucous Membrane;Myeloid Cells;Neisseria gonorrhoeae;Neurocognitive;novel;novel strategies;Oral;oral bacteria;Oral cavity;Oral Characters;Oral Examination;oral infection;oral microbial community;oral microbiome;Oral mucous membrane structure;Outcome;Participant;Pathogenesis;Periodontal Diseases;Persons;Pharyngeal structure;polymeric IgA;Polymers;Populations at Risk;Predisposition;Process;Public Health;Research;response;Risk;risk prediction;Role;Saliva;saliva analysis;Salivary immunoglobulin A;Sexually Transmitted Diseases;Shotguns;Single Nucleotide Polymorphism;Site;Specimen;success;systemic inflammatory response;Technology;Testing;time use;tool;Validation;Viral;Viremia;Virus Replication;Work

PROJECT_TITLE: Role of the oral microbiome in driving local and systemic inflammation in HIV

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This multidisciplinary training program represents a team approach, involving multiple principal investigators who will continue to mentor predoctoral students and post-doctoral fellows. The program will emphasize fundamental aspects of cancer biology, translational science of cancer and therapeutics, and clinical cancer, as well as prepare trainees as independent scientists and investigators who can become fully integrated in multidisciplinary cancer care teams.

PI_NAMEs: EVERS, BERNARD MARK;O'CONNOR, KATHLEEN L. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer Biology;Interdisciplinary Study;Research Training

PROJECT_TITLE: Interdisciplinary Research Training in Cancer Biology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: PROJECT NARRATIVE. As the proportion of the American population over the age of 65 increases, there will be an increase in the number of individuals afflicted with Alzheimer’s disease with neither a complete understanding of the pathophysiology of this illness nor effective, disease-altering therapies. Metabolic dysfunction is a hallmark of Alzheimer’s disease and the master regulator of metabolic homeostasis, adenosine monophosphate activated protein kinase (AMPK), may play a critical pathophysiologic role in this disease. This proposal seeks to measure AMPK in vulnerable regions of postmortem AD brain and manipulate AMPK in neurons derived from AD patient iPSCs, ultimately providing novel pathophysiologic insights and advancing the opportunity to develop new therapies.

PI_NAMEs: HENKEL, NICHOLAS DANIEL (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Address;Adenosine Monophosphate;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloid;Automobile Driving;Autopsy;Biochemical;Bioinformatics;Brain;Brain region;career;Cell Culture Techniques;Cell Nucleus;cell type;Cellular biology;Clinical;Clinical Trials;Complement;Consensus;Data;Data Set;Dementia;Disease;disease phenotype;Disease Progression;effective therapy;Enzymes;experience;experimental study;Fellowship;Functional disorder;genetic manipulation;Goals;Hippocampus;Homeostasis;Human;human old age (65+);in silico;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived neurons;insight;Literature;Measures;Mentors;Metabolic;Metabolic dysfunction;Metabolism;mild cognitive impairment;Mitochondria;Nerve Degeneration;Neurons;novel;novel therapeutics;Nuclear;overexpression;Pathogenesis;Pathologic;patient derived induced pluripotent stem cells;Pattern;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Play;Population;pre-clinical;Prefrontal Cortex;Preparation;Prevalence;prospective;Protein Isoforms;Protein Kinase;proteostasis;Public Health;Regulation;Research;Role;Sampling;Scientist;Signal Transduction;stem cells;Synapses;synaptic function;tau-1;Techniques;Testing;tissue processing;Training;transcriptomics;translational physician;United States

PROJECT_TITLE: AMPK localization, expression, and activity in Alzheimer's Disease


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Patient Safety;Rehabilitation;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Simple mastectomy amputates all of the breast tissue, including the third through sixth intercostal nerves, leaving the breast numb. The resulting deafferentation leads to major adverse effects, including a disembodiment of the breasts, loss of touch-based affective communication, abolition of breast-centered erogenous touch, and, in many women, the development of chronic pain. Our objective is to lay the groundwork for a neuroprosthetic solution to the negative sensory sequelae of mastectomy by establishing that touch sensation can be restored to the breast via bionics.

PI_NAMEs: LINDAU, STACY TESSLER (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Adverse effects;Affect;Affective;Amputees;Analgesics;bench to bedside;Bilateral;Biomimetics;Bionics;Breast;Breast Cancer Risk Factor;Breast Cancer survivor;Case Study;Chest;chronic neuropathic pain;chronic pain;Communication;Complex;Conscious;cost;Cutaneous;Data;Deafferentation procedure;design;Development;Devices;Distress;Electric Stimulation;Electrodes;Electronics;Esthesia;experience;Fascicle;Feeling;foot;Frequencies;Future;Goals;Hand;Human;Implant;implantation;Implanted Electrodes;improved;In Situ;Injury;Intervention;limb amputation;Limb structure;Location;Malignant Breast Neoplasm;Mammaplasty;Mammary Gland Parenchyma;Mastectomy;Measures;median nerve;Nerve;nerve supply;neural patterning;neural stimulation;neuroprosthesis;Nipples;novel;Numbness;Operative Surgical Procedures;Pain;pain reduction;Participant;Patients;Phantom Limb Pain;Phase 0 Trial;Physiologic pulse;pressure;primary outcome;Probability;Procedures;Process;Psychophysics;Quality of life;reconstruction;Reconstructive Surgical Procedures;Recovery;Research;Residual state;Risk;Risk Reduction;Safety;sensor;Sensory;Signal Transduction;Simple mastectomy;somatosensory;Structure of radial nerve;Structure of ulnar nerve;success;Surgical complication;surgical risk;Symptoms;Technology;Testing;Time;Tissues;Touch sensation;United States Food and Drug Administration;Ventral thoracic nerve structure;Woman

PROJECT_TITLE: Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Pain Research;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Invasive procedures to open arteries supplying the legs for patients with pain and peripheral artery disease (PAD) include risks of complications and uncertainty around individual benefits. Aligning goals and values between patients with PAD and available treatment options requires better evidence of patient-centered outcomes and a deeper understanding of the decision-making process. The proposed work leverages complementary methods in advanced statistics and decision science to address these gaps, enabling clinicians and patients to make more informed, personalized, and goal-concordant decisions about PAD care.

PI_NAMEs: SECEMSKY, ERIC ALEXANDER (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Administrator;Advisory Committees;Affect;African American;Aftercare;American;Applications Grants;Arteries;Award;Belief;Benefits and Risks;Biometry;Biostatistical Methods;Blood Vessels;Cardiology;Cardiovascular system;career;career development;Caring;Classification;claudication;Clinic;Clinical;clinical care;Clinical Investigator;clinical practice;clinical training;comparison intervention;Conflict (Psychology);Consultations;cost;Data;Decision Aid;Decision Making;design;Development;diagnostic tool;disability;Elements;empowerment;Environment;Evaluation;Evidence based treatment;Exercise;experience;Future;Goals;health care service utilization;Health Expenditures;Health Status;Hemorrhage;Heterogeneity;implementation science;implementation strategy;improved;Individual;individual patient;individualized medicine;Intervention;intervention cost;Interview;Kidney Failure;Knowledge;Leg;Location;Lower Extremity;Measures;Medical;medical specialties;Medicine;men;Mental Depression;Mentors;Mentorship;Methods;Modeling;Multicenter Trials;novel;Nurses;Outcome;Outcome Measure;Outcomes Research;Outpatients;Pain;Patient Care;Patient Outcomes Assessments;Patient Preferences;Patient-Focused Outcomes;Patients;Peripheral;Peripheral arterial disease;Physicians;Pilot Projects;pilot test;Policy Maker;practice setting;pragmatic implementation;Predictive Factor;preference;Procedures;Process;prognostication;Program Development;prospective;Provider;Qualitative Methods;Qualitative Research;Quality of Care;Quality of life;Questionnaires;Race;Readiness;Research;Research Methodology;Research Personnel;Research Training;Resources;response;Risk;Science;Scientist;Selection for Treatments;shared decision making;skills;statistics;Structure;symptomatic improvement;Symptoms;Therapeutic;tool;treatment as usual;treatment choice;Treatment outcome;treatment strategy;Uncertainty;Woman;Work

PROJECT_TITLE: Shared Decision-Making to Improve the Health Status of Patients with Claudication: Developing and Implementing Strategies to Individualize Treatment Decisions

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Pediatric;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: 2. Project Narrative. We will continue a research training and career development program, the OHSU Women's Reproductive Health Research K12 Program, that will prepare obstetrician-gynecologists to become physician-scientists and develop independent research careers. It will be a multi-disciplinary effort pulling together mentor teams from throughout OHSU. The primary aim of the program is to produce highly qualified and independently funded OB/GYN researchers who will conduct research across the reproductive life cycle.

PI_NAMEs: CAUGHEY, AARON B (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Cardiovascular system;career development;Clinical Research;Collaborations;Conceptions;Contraceptive Agents;Development;Developmental Biology;Effectiveness;embryo/fetus;Family Planning;Fetal Diseases;fetal programming;Fostering;Foundations;Functional disorder;Funding;Grant;Gynecologist;Health;interest;Life Cycle Stages;Maternal Physiology;Measures;Mentored Clinical Scientist Development Program;Mentors;Mentorship;multidisciplinary;offspring;Oregon;Outcome;Ovarian;Physicians;Pregnancy Complications;Prenatal care;Primates;Productivity;Program Development;programs;Qualifying;recruit;reproductive;Reproductive Biology;reproductive development;Reproductive Health;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Training;Science;Scientist;skills;success;Training;Training and Infrastructure;Translational Research;Universities;Uterus;Woman;Women's Health;women's reproductive health;Writing


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This K24 renewal will sustain and enhance the supportive mentoring environment for Dr. Laufer’s trainees from undergraduate students to junior faculty, with a focus on diversity and inclusion among the trainees. This award, along with Dr. Laufer’s existing grants, provide innovative and public health relevant research opportunities for the trainees to develop their independent careers and improve global health.

PI_NAMEs: LAUFER, MIRIAM K. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 2019-nCoV;5 year old;Address;adverse birth outcomes;Africa South of the Sahara;age group;Anopheles Genus;Area;Award;Birth;Blood;career;career development;Child;Child Development;Child Health;Clinical;Clinical Research;clinically significant;co-infection;cohort;Communicable Diseases;congenital infection;Country;COVID-19 pandemic;Culicidae;Data;Dedications;Development;Disease;diversity and inclusion;Enrollment;Environment;epidemiology study;equity, diversity, and inclusion;Exposure to;Faculty;Funding;Funding Mechanisms;Ghana;global health;Grant;Growth;Health;High Prevalence;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;hypoperfusion;Immune;Immunity;Impairment;implementation study;improved;in utero;Infant;Infant Health;Infection;Infection prevention;infectious disease treatment;Infectious Diseases Research;Inflammation;Infrastructure;innovation;Institution;International;international center;Intervention;K-Series Research Career Programs;Kenya;Laboratories;Leadership;Malaria;malaria infection;Malaria prevention;malaria transmission;Malaria Vaccines;Malawi;Maternal Mortality;maternal risk;Measures;Medicine;Mentors;Mid-Career Clinical Scientist Award (K24);Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;Neonatal;neonate;Neurocognitive;next generation;offspring;Outcome;pandemic disease;Parasites;patient oriented research;Perinatal mortality demographics;Placenta;Plasmodium falciparum;Policies;Positioning Attribute;Pregnancy;Pregnant Women;Premature Birth;prenatal exposure;Prevalence;prevent;Prevention;Principal Investigator;programs;prospective;Public Health;Randomized;Recommendation;recruit;Research;Research Activity;Research Design;Research Personnel;Resource-limited setting;Risk;Role;safety and feasibility;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;School-Age Population;Seroprevalences;Source;Time;tool;Training;translational applications;Translational Research;Translations;transmission process;undergraduate student;United States National Institutes of Health;Vaccination;vaccine trial;Vaccines;vaccinology;Woman;Work;World Health Organization

PROJECT_TITLE: Mentoring in patient-oriented research in global health

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE HCC represents a growing healthcare burden with very limited therapeutic options and poor survival rate. We have discovered a new role of the cytokine IL27 in HCC development, allowing us to put forward an exciting hypothesis that IL27 suppresses both innate and adaptive anti-cancer immunity and may represent a potential target for pharmacological interventions. In this proposal, we will elucidate cellular and molecular mechanisms by which IL27 mediates its tumorigenic effects on innate and adaptive immune cells in HCC and test how its blockade may be used to reinvigorate anti-HCC immune responses. 1

PI_NAMEs: KOLTSOVA, EKATERINA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;adaptive immune response;anti-cancer;Anti-Inflammatory Agents;anti-tumor immune response;Antibodies;arm;Autoimmune Diseases;Autoimmunity;Biological Assay;Biological Response Modifiers;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular Metabolic Process;checkpoint therapy;Chronic;Cirrhosis;cytokine;cytotoxic;cytotoxicity;Data;Developed Countries;Development;Disease;efficacy testing;exhaustion;Family;Frequencies;Genetic;Genetic Transcription;Growth;Growth and Development function;healthcare burden;Heavy Drinking;Hepatitis B;Hepatitis B Incidence;Hepatitis C Incidence;Hepatocyte;Histologic;Human;IL27RA gene;IL6 gene;Immune;immune cell infiltrate;Immune response;Immunologic Markers;Immunologics;immunoregulation;Immunotherapy;In Vitro;in vivo;in vivo Model;Incidence;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Injury;Innate Immune Response;Interleukin-12;Interleukins;Intervention;Knock-out;Liver;liver cancer model;liver inflammation;liver injury;Malignant neoplasm of liver;Mediating;Mediator;Medical;member;Modality;Modeling;Molecular;Molecular Biology;mortality;mouse model;Mus;Natural Killer Cells;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity;Obesity Epidemic;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Preventive;Primary carcinoma of the liver cells;programmed cell death protein 1;Proliferating;receptor;Regulation;Repression;Research;response;Risk Factors;Role;Scheme;Serum;Signal Transduction;Steatohepatitis;Survival Rate;T cell response;T-Cell Depletion;targeted cancer therapy;Testing;Therapeutic;therapeutic evaluation;transcriptomics;translational potential;tumor;tumor growth;Tumor Immunity;tumorigenesis;tumorigenic;Up-Regulation;Virus Diseases;Work

PROJECT_TITLE: IL-27R signaling as a negative regulator of innate and adaptive anti-cancer immunity in hepatocellular carcinoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

PHR: Relevance to Public Health Evidence-based preventive health services are vastly underutilized by older Americans. This proposal’s promising multilevel intervention will stimulate greater use of the Medicare Annual Wellness Visit, an established but underused mechanism that gives providers dedicated time to focus on preventive health services. The anticipated increase in preventive health services stemming from greater Annual Wellness Visit use will improve population health and lower mortality, particularly in at-risk racial/ethnic minority patients.

PI_NAMEs: TARN, DERJUNG M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academy;Address;Adult;Affect;American;Caring;Communities;community based practice;Country;Couples;Data;Data Coordinating Center;Dedications;design;Electronic Health Record;Electronics;Eligibility Determination;Equity;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Evaluation;evidence base;Evidence based intervention;Family Physicians;Federally Qualified Health Center;Fee-for-Service Plans;Feedback;Future;Geography;Goals;Health;health data;health service use;Health Services Needs;Health system;human old age (65+);implementation intervention;implementation strategy;improved;Individual;individual patient;Intervention;intervention cost;intervention effect;intervention refinement;life span;Low income;low socioeconomic status;Medicare;Methods;minority patient;Morbidity - disease rate;mortality;National Cancer Institute;novel;Nursing Staff;older adult;Outcome Assessment;Patients;Persons;Population;population health;post implementation;practice setting;practice-based research network;pragmatic trial;Preventive;Preventive care;Preventive Health Services;Preventive service;primary care practice;Provider;Public Health;racial disparity;racial diversity;racial minority;racial minority population;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research;Resources;Risk;Risk Assessment;screening;Screening for cancer;screening services;Services;Solo Practices;stem;Time;tool;United States;United States Preventative Services Task Force;uptake;Vaccination;Videoconferencing;Visit;wellness visit;Work

PROJECT_TITLE: Increasing the Feasibility, Impact, and Equity of the Medicare Annual Wellness Visit (AWV)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]