ORG_CITY: TAHLEQUAH

ORG_NAME: CHEROKEE NATION

ORG_STATE: OK

PHR: Project Narrative Natives suffer from a range of health inequities. CN NARCH will expand tribal capacity to address these disparities through a coordinated research involving career enhancement, capacity building, and research activities.

PI_NAMEs: KHAN, SOHAIL IMRAN (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Advisory Committees;Affect;American Indian community;American Indian Population;American Indians;Biomedical Research;career;career development;Cherokee Nation;Clinical;Code;comorbidity;COVID-19;Data;Disease;Disparity;Early Diagnosis;Early treatment;Education;Ensure;Environment;Environmental Risk Factor;ethical, legal, and social implication;Evaluation;experience;Faculty;Foundations;Funding;Genomics;Goals;Health;health application;health care availability;Health care facility;Health Disparities Research;health disparity;health inequalities;Health Occupations;Health Services;Immersion;improved;Indian reservation;Indigenous;Infection;Infrastructure;innovation;interest;Leadership;Long COVID;long term consequences of COVID-19;Medical Research;medical schools;Mentorship;Mission;Monitor;Morbidity - disease rate;mortality;Native American Research Center for Health;Native American Tribe;Native Americans;natives;next generation;Oklahoma;Patients;Population;primary care provider;programs;Psychologist;Psychology;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Reservations;Rheumatism;Rheumatoid Arthritis;Rheumatology;Scientist;Scleroderma;Severity of illness;student participation;Students;success;System;systemic autoimmune disease;Systemic Lupus Erythematosus;Training;tribal member;tribal Nation;Tribally Based Participatory Research;Tribes;undergraduate student;United States Indian Health Service;Universities;Work

PROJECT_TITLE: NARCH 12


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sensory experience during postnatal development refines an embryonic blueprint of the primary somatosensory cortex (S1), endowing it with an array of functions made possible by neural circuits composed of hundreds of cell types. In Autism Spectrum Disorders (ASDs), this experience-dependent plasticity is compromised, resulting in the impaired development of sensorimotor function. This project will combine single-nucleus mRNA sequencing, machine learning, and histology with sensory deprivations and a transgenic mouse model of autism to uncover the influence of ASD on experience-dependent cell type maturation and provide a framework for developing cell type-specific therapeutic interventions.

PI_NAMEs: BUTRUS, SALWAN  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Anatomy;area striata;ASD patient;autism spectrum disorder;barrel cortex;Brain;Cell Nucleus;cell type;Cells;Classification;cognitive function;Computational Biology;critical period;deprivation;Development;differential expression;dimension reduction;Disease;Electrophysiology (science);Embryo;Endowment;experience;experimental study;Fluorescent in Situ Hybridization;Fragile X Syndrome;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Glutamates;Graph;Health;Heterogeneity;Histology;Human;Impairment;improved;Intellectual functioning disability;Knock-out;Knockout Mice;Knowledge;Life;Machine Learning;machine learning pipeline;Maps;Measurement;model of autism spectrum disorder;Modeling;Molecular;Morphology;mouse model;mRNA sequencing;Mus;neocortical;neural circuit;Neurodevelopmental Disorder;Neurons;Pathology;Pattern;Physical Function;Physiological;postnatal;postnatal development;programs;Reaction;Resolution;Resources;response;Role;Sensorimotor functions;Sensory;sensory cortex;Sensory Deprivation;Series;single nucleus RNA-sequencing;Social Development;Social Functioning;somatosensory;Somatosensory Cortex;Specific qualifier value;Stereotyping;Structure;supervised learning;Synapses;synaptogenesis;Tactile;targeted treatment;temporal measurement;Testing;Therapeutic Intervention;Time;Tissues;transcriptomics;Transgenic Mice;unsupervised learning;Validation;Vibrissae;Vision;Visual;Wild Type Mouse;Work

PROJECT_TITLE: Single-cell Transcriptomic Analysis of Cell Type Plasticity in Barrel Cortex of Normal and Autism Model Mice


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;Affect;Ally;anti-cancer research;Attention;career;Cherokee Indian;Cherokee Nation;Communication;Complex;Decision Making;Development;Ensure;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Health;health disparity;health equity;Health Occupations;Health Services;implementation process;improved;Infrastructure;Institution;Institutional Review Boards;Joints;Leadership;Medical Research;Mentors;National Cancer Institute;Native American population;Native American Research Center for Health;Native Americans;novel;Oklahoma;Pathway interactions;Procedures;Process;Program Evaluation;programs;Research;Research Activity;Research Project Grants;Resources;shared decision making;Structure;Students;success;System;Training;Training Activity;tribal community;tribal health;Tribally Based Participatory Research;Tribes;undergraduate student;Universities

PROJECT_TITLE: ADMIN-CORE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: VESELY, SARA KATHERINE (contact)

PROJECT_TERMS: Address;American Indian Population;American Indians;anti-cancer research;Bachelor's Degree;behavioral health;career;Career Choice;Cherokee Indian;Cherokee Nation;Clinical;Collaborations;college;Communities;Country;County;cultural competence;Dedications;Education;education pathway;education research;Educational workshop;Evaluation;experience;Exposure to;Face;Faculty;faculty mentor;falls;Fostering;Foundations;Funding;Goals;graduate school;graduate student;hands on research;Health;health equity;health inequalities;Health Sciences;high school;High School Student;Immersion;improved;Inequity;innovation;Institution;Institutional Review Boards;Institutionalization;inter-institutional;interest;Leadership;Location;Medical Students;Medicine;Mentors;Mentorship;Methods;National Cancer Institute;Native American Research Center for Health;next generation;Oklahoma;online community;Outcome;Pathway interactions;Positioning Attribute;professional students;Program Development;Program Sustainability;programs;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;responsible research conduct;Scientist;Services;skills;Students;Support System;Training;Training Programs;tribal institution;tribal Nation;Tribes;undergraduate research experience;undergraduate student;Universities

PROJECT_TITLE: Cherokee Nation Research Immersion Student Experiences( Cherokee Rise)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE: Although breast cancer patient survival has improved in the last two decades, metastatic stage disease remains the highest killer of breast cancer patients. Successful metastasis relies on the earliest stages of pre-metastatic microenvironment formation in which vascular smooth muscle cell-derived extracellular fibronectin and collagen 1a1 proteins fill the organ parenchyma, yet no biomarker of the primary tumor can predict or identify the probable or ongoing coordination of this process, nor is there a defined tumor target to therapeutically block pre-metastatic microenvironment formation. The aim of this project is to investigate the first ever probable link between breast epithelial cell metastasis suppressor obscurin loss and pre-metastatic microenvironment formation, highlighting a potential novel tumor biomarker and target for incoming or ongoing metastatic disease.

PI_NAMEs: EASON, MATTHEW KENT (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;AKT2 gene;Automobile Driving;Back;Biochemical;Biological Markers;Breast;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;Breast Epithelial Cells;Cell Adhesion;Cell Line;cell motility;Cell secretion;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Type I;Deposition;Development;diagnostic biomarker;Disease;Distant;Down-Regulation;Environment;Evaluation;exosome;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibronectins;Generations;Genes;Goals;Human;improved;In Vitro;Invaded;Knock-out;Knowledge;KRAS2 gene;Link;Lung;lung colonization;lung metastatic;Malignant Breast Neoplasm;mammary epithelium;Mammary Neoplasms;MCF10A cells;Mediating;Membrane Proteins;metastasis prevention;Metastatic Neoplasm to the Lung;migration;Modeling;Mus;Muscle;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;obscurin;Oncogene Activation;Oncogenes;Organ;Pathway interactions;Patients;Phenotype;PIK3CG gene;Population;Prevention;Primary Neoplasm;Probability;Process;Production;Proteins;Published Comment;Pulmonary artery structure;Reporting;Research;response;restoration;Risk;Role;Sarcomeres;Smooth Muscle Myocytes;Stromal Cells;Structure of parenchyma of lung;Testing;Therapeutic;transcription factor;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Markers;tumor microenvironment;Tumor Suppressor Proteins;Tumor-Derived;tumorigenesis;Up-Regulation;Vacuum;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Work

PROJECT_TITLE: Obscurin-Deficient Breast Epithelia Generate Secreted Factors that Prime Lung Vascular Smooth Muscle Cell Pre-metastatic Microenvironment Formation


NIH_SPENDING_CATS: American Indian or Alaska Native;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Infectious Diseases;Palliative Care;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: KUHN, KATRIN GAARDBO (contact)

PROJECT_TERMS: 5 year old;acute COVID-19;Address;Adult;Affect;Age;American;American Indian Population;American Indians;Anxiety;Cardiovascular system;Caring;Cessation of life;Cherokee Nation;Child;Child Health;Clinic;cohort;Cohort Studies;Coin;Communities;Community Surveys;comorbidity;Contact Tracing;COVID-19;COVID-19 impact;COVID-19 incidence;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 patient;COVID-19 test;Dedications;Disease;Dizziness;Eligibility Determination;experience;Fatigue;Future;gastrointestinal;Gender;Goals;Guidelines;Health;Health care facility;health inequalities;Healthcare;Healthcare Systems;Heart;high risk;Hospitalization;improved;Incidence;Indian reservation;Infection;Intensive Care;Interview;Knowledge;Long COVID;long term consequences of COVID-19;Long-Term Effects;long-term sequelae;Medical;member;Memory;Mental Depression;Native American Research Center for Health;Oklahoma;Outpatients;pandemic disease;Paper;Participant;Patient risk;Patients;persistent symptom;Persons;Population;post SARS-CoV-2 infection;post-COVID-19;Prevalence;primary care provider;prospective;psychologic;Public Health;Publishing;Questionnaires;Race;Reporting;Review Literature;Risk;rural counties;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 positive;severe COVID-19;Severity of illness;Surveys;symptom management;symptomatic COVID-19;Symptoms;Telephone Interviews;Test Result;Testing;Time Study;tribal community;Visit

PROJECT_TITLE: Long-term consequences of SARS-CoV-2 infection and COVID-19 disease among American Indians: an ambidirectional cohort study in the Cherokee Nation


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Type 1 conventional dendritic cells (cDC1s) are critical for the generation of effective immune responses against intracellular pathogens and tumors, but how cDC1s localize to sites of immune insult is incompletely understood. We have found that GPR34, an understudied G protein-coupled receptor, can cell-intrinsically promote cDC1 accumulation and that the receptor can suppress the growth of implanted tumors. This proposal builds off these preliminary data to mechanistically dissect how GPR34 controls cDC1 migration, positioning, and function during inflammation and cancer.

PI_NAMEs: TAM, HANSON PETER (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adaptive immunity;Antigen Presentation;antigen-specific T cells;Antigens;Area;Biological Assay;Biological Models;Biology;Bone Marrow;California;cancer cell;career;CD8-Positive T-Lymphocytes;Cell Communication;cell motility;Cell Physiology;cell type;Cells;Cellular Assay;Chemotactic Factors;Chimera organism;Clinical;clinical training;Collaborations;Colon Adenocarcinoma;colon cancer metastasis;Colon Carcinoma;Colorectal Cancer;Confocal Microscopy;Cross Presentation;Data;Dendritic Cells;druggable target;Educational workshop;Engineering;Environment;Enzymes;Epithelial ovarian cancer;experimental study;Flow Cytometry;G-Protein-Coupled Receptors;Generations;Goals;Greater sac of peritoneum;Growth;Immune;Immune response;Immunity;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunology;Implant;In Vitro;in vivo;Infection;Inflammation;innovation;Journals;Kinetics;Ligands;Link;Liquid substance;Lymphoid Tissue;lysophosphatidylserine;Malignant neoplasm of ovary;Malignant Neoplasms;MC38;Measures;Mediating;Mediator;medical schools;Mentorship;Microanatomy;migration;Migration Assay;Modeling;Mus;Natural Immunity;Neoplasm Metastasis;Organ;Outcome;Ovalbumin;overexpression;pathogen;Peritoneal;Peritonitis;Phenotype;Physicians;Physiology;Positioning Attribute;Postdoctoral Fellow;Process;Proliferating;Qualifying;receptor;recruit;Reporting;Research;response;Role;San Francisco;Scientist;Shapes;Signal Transduction;Site;skills;Source;subcutaneous;Supporting Cell;symposium;System;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic development;Thioglycolates;Time;tool;trafficking;Training;tumor;Tumor Cell Line;tumor growth;Tumor Immunity;Universities;Visualization;Vocational Education;Weight;Work;XCR1 gene

PROJECT_TITLE: Dissecting the role of GPR34 in cDC1 migration and function


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Microbiome;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Alcohol use disorder can affect the liver causing cirrhosis, in whom currently available medicines are not safe or are poorly studied, requiring newer approaches. Patients with alcohol use disorder, especially with liver disease, have an unfavorable alteration of their gut microbes, which can propagate the disease, and can potentially be corrected through fecal microbial transplantation (FMT). In this proposal, we aim to perform a trial using FMT compared to placebo in patients with alcohol use disorder with liver cirrhosis to determine its effect on alcohol consumption and craving, changes in microbes and on liver and brain function.

PI_NAMEs: BAJAJ, JASMOHAN S (contact);KHORUTS, ALEXANDER

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Abstinence;Affect;Alcohol consumption;alcohol craving;alcohol use disorder;alcohol use initiation;Alcohol-Induced Disorders;Alcoholic Hepatitis;Alcohols;Aminobutyric Acids;Antibiotics;Antimicrobial Resistance;base;Behavioral;Bile Acids;Biological;Brain;brain dysfunction;capsule;Cirrhosis;Clinical;Clinical Trials;Clostridium difficile;Cognition;Cognitive;cognitive function;cognitive testing;Cognitive Therapy;comparative;craving;Development;Disease;disorder prevention;Double-Blind Method;double-blind placebo controlled trial;Encapsulated;enema administration;Engraftment;Enrollment;evidence base;experience;FDA approved;fecal transplantation;Feces;Formulation;Freeze Drying;Functional disorder;gamma-Aminobutyric Acid;Glutamates;Goals;Good Manufacturing Process;gut dysbiosis;gut microbes;gut microbiota;gut-brain axis;health related quality of life;Hepatic Encephalopathy;improved;Infection;Infrastructure;instrument;Link;Liquid substance;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;liver function;liver injury;liver transplantation;manufacture;Measures;Mediator;Medicine;metabolomics;Microbe;microbial;microbial community;microbial composition;microbiota;Minority;Molecular;Monitor;Morbidity - disease rate;mortality;novel strategies;Oral;Organ;Participant;Patient Outcomes Assessments;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Placebos;Plasma;Population;Preparation;primary outcome;Probiotics;Prognosis;psychologic;Psychometrics;psychosocial;psychosocial outcome;Publishing;Randomized;randomized placebo-controlled clinical trial;randomized trial;Recurrence;Safety;safety outcomes;Serum;Services;Sickness Impact Profile;Socioeconomic Status;Standardization;Structure;success;Testing;Therapeutic;therapeutic target;trial design;Underserved Population;urinary;Volatile Fatty Acids

PROJECT_TITLE: Fecal microbiota transplant for Alcohol-Associated Cirrhosis


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Metastasis, the process by which tumor cells spread to distant organs, remains an untreatable facet of tumor progression and is responsible for the majority of cancer-related deaths. The proposed studies aim to define the role of a novel subset of monocytes during metastasis. This research will further our knowledge on the mechanisms used by monocytes to promote metastasis and will contribute to the design of more effective myeloid-targeting therapies.

PI_NAMEs: SUPERVILLE, DAPHNE A (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Academia;advanced disease;Anoikis;Biology;Body part;breast cancer metastasis;career;Cell Separation;Cell Survival;cell type;Cells;Cessation of life;Communication;Communities;Coupled;cytokine;Data;Data Analyses;Dendritic Cells;design;Disease;Disseminated Malignant Neoplasm;Distant;Education;Educational process of instructing;experience;Extracellular Matrix;Fibronectins;Future;Gene Expression Profile;Gene Expression Profiling;Gene set enrichment analysis;Genes;Heterogeneity;Human;Immune;immune cell infiltrate;Immune response;Institution;Knowledge;Lung;lung metastatic;Macrophage;Malignant Neoplasms;Measures;Mediator;Medical center;Mentors;Mentorship;Metabolic;Metabolism;Modeling;monocyte;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;new therapeutic target;novel;novel therapeutics;Oncologist;Organ;overexpression;Oxidative Phosphorylation;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pattern;Phenotype;Play;Population;Population Heterogeneity;preservation;Process;programs;protein complex;protein expression;Publishing;recruit;Research;Research Personnel;Research Training;Resistance;Role;Science;Shapes;single-cell RNA sequencing;Site;skills;Structure of parenchyma of lung;Students;targeted treatment;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;Training;Transcript;transcriptomics;tumor;tumor immunology;tumor progression;tumor-immune system interactions;Up-Regulation;Work;Workplace

PROJECT_TITLE: Defining a novel subset of metastasis-associated monocytes


NIH_SPENDING_CATS: American Indian or Alaska Native;Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Infectious Diseases;Lupus;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rheumatoid Arthritis;Scleroderma

PI_NAMEs: JAMES, JUDITH A (contact)

PROJECT_TERMS: 2019-nCoV;Academic Detailing;Algorithms;Antibodies;Arthralgia;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune rheumatologic disease;Autoimmunity;Automobile Driving;Binding;Cardiolipins;Caring;Case Based Learning;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cherokee Indian;Cherokee Nation;Cities;Clinic;Clinical Research;Clinical Research Protocols;Cotinine;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 patient;cytokine;Cytomegalovirus;Cytometry;Data;Degenerative polyarthritis;Development;Diagnosis;Disease;Disease Outcome;Dissemination and Implementation;Early Diagnosis;Early Intervention;Early treatment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epstein-Barr virus early antigen;Evaluation;Exanthema;Fatigue;Foundations;Future;Genomics;Goals;Grant;Health;Health system;Heart;Human Herpesvirus 4;Immune;Immune System Diseases;Immunophenotyping;immunoregulation;improved outcome;Individual;Infection;infection rate;Infrastructure;Legal patent;Long COVID;Lung;Lupus;Malaise;Measures;Medical Research;Methods;Morbidity - disease rate;mortality;multiple omics;Myalgia;Native American population;Native American Research Center for Health;Native Americans;novel;Oklahoma;Outcome;participant enrollment;Pathway interactions;patient engagement;Patients;Population;Prevention;primary care clinic;primary care provider;Production;programs;proteogenomics;Provider;Race;response;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Rivers;SARS-CoV-2 antibody;SARS-CoV-2 infection;Scleroderma;Self Tolerance;single cell genomics;smoking exposure;Symptoms;systemic autoimmune disease;Systemic Lupus Erythematosus;Systemic Scleroderma;Testing;Thrombosis;Time;tribal community;tribal member;Tribes;Vaccines;Viral;Virus Diseases;Vitamin D Deficiency;Work

PROJECT_TITLE: Environmental Influences Driving Autoimmunity and Autoimmune Disease in Tribal Members


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative A-to-I RNA editing is a very prevalent type of RNA modification in human cells. An increasing number of A-to-I editing sites is being identified in various organisms, but mostly having unknown functional roles or regulatory mechanisms. The proposed research aims to develop and apply bioinformatic methods to study the function and regulation of RNA editing in cancer, providing a basis for future studies on how RNA editing may contribute to human diseases.

PI_NAMEs: XIAO, XINSHU GRACE (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3' Untranslated Regions;ADAR1;Address;Adenosine;Affect;Amino Acid Sequence;Base Sequence;Bioinformatics;cancer cell;Cancer Control;Cancer Patient;cancer risk;cancer type;cell type;Cells;Code;Collection;Data;Data Set;DNA Sequence Alteration;Double-Stranded RNA;DRADA2b protein;Enzymes;Epithelium;Future;Gene Expression;Genes;genetic architecture;Genomics;Goals;Heterogeneity;Human;human disease;Immune response;Immune Response Genes;immunoregulation;Immunotherapy;Inosine;insertion/deletion mutation;insight;Interferon Activation;Interferons;Label;Malignant Neoplasms;Mammals;Mesenchymal Cell Neoplasm;Methodology;Methods;Modification;Molecular;mRNA Stability;Mutation;Natural Immunity;neuropsychiatric disorder;novel;Nucleotides;Organism;Outcome;Pathway interactions;Patients;Pattern;Phenotype;posttranscriptional;prevent;Proteins;Proteomics;Regulation;Reporting;Research;response;RNA;RNA analysis;RNA Editing;RNA Sequences;RNA-Binding Proteins;Role;Sampling;secondary analysis;Site;Structure;success;Technology;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;Untranslated RNA;Validation;Work

PROJECT_TITLE: Exploiting public genomic and transcriptomic data to uncover cancer-RNA editing relationships

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HARTFORD

ORG_STATE: CT

PHR: FOOD SAFETY &  AG. COMMODITIES STATE OF CONNECTICUT 860-713-2513  ANIMAL CONTROL 860-713-2506  DEPARTMENT OF AGRICULTURE DAIRY/MILKSAFETY 860-713-2508  PRODUCE SAFETY 860-713-2522 LIVESTOCK/POULTRY  BUREAU OF REGULATORY SERVICES 860-713-2504  STATE VETERINARIAN 860-713-2505 PAR-20-132 Development and Maintenance of the Animal Feed Regulatory Program Standards with Optional Coordinated Preventive Control Regulatory Activities and Capacity Building (U18) Please see the included Research Plan for the full project narrative for the proposal entitled “ CT DoAg Maintenance of the Animal Feed Regulatory Program Standards (AFRPS)”. Wayne Kasacek, BS, RS Assistant Bureau Director CT Dept. of Agriculture Bureau of Regulatory Services 860-713-2508 Wayne.kasacek@ct.gov 450 COLUMBUS BLVD., SUITE 702  HARTFORD, CT 06103

PI_NAMEs: NELSON, KATE  (contact)

PROGRAM_OFFICER_NAME: CLARK, JACOB


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: BLANCHARD, JESSICA  (contact)

PROJECT_TERMS: Address;Agreement;Alaska Native;American Indians;Articulation;Attention;bean;biobank;Biological;biological research;Biomedical Research;Biotechnology;Cherokee Indian;Cherokee Nation;Code;cohort;Collaborations;Collection;Communities;Consult;Data;data sharing;design;Development;Employee;Equipment and supply inventories;ethical, legal, and social implication;Ethics;Face;Funding;Genomics;Goals;Health;Indigenous;Information Systems;innovation;Institutional Review Boards;interest;Legal;meetings;member;Native American Research Center for Health;Oklahoma;Ownership;Persons;Policies;precision medicine;Procedures;programs;Protocols documentation;RADx Underserved Populations;Regulation;Research;research and development;Research Infrastructure;Research Personnel;Research Training;Resources;Rights;Role;Sampling;Scholars Program;Self Determination;Series;Services;Shapes;Specimen;Structure;Students;Training;training opportunity;tribal Nation;Tribes;Universities;Work

PROJECT_TITLE: Building Tribal Capacity through Informing the Development of Tribal Research Codes to Govern Genomic Research: A Collaboration between Cherokee Nation and the University of Oklahoma


ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE DEPT/FOOD/AGRICULTURE

PHR: Project Narrative The goal of the proposed project is to support the California Department of Food and Agriculture (CDFA) Commercial Feed Regulatory Program (CFRP) in maintaining and enhancing its full implementation of the Animal Feed Regulatory Program Standards (AFRPS) while building the program’s ability to perform regulatory work and promote compliance with the Preventive Controls for Animal Food (PCAF) rule. In addition to maintaining full conformance, the CFRP will augment and update existing AFRPS procedures to ensure full support of Preventive Controls of Animal Food work through continued extensive collaboration, cooperation, and coordination with the U.S. Food and Drug Administration, other national, state and local agencies, and industry. These activities will further enhance CFRP’s ability to prevent, intervene, and respond to animal feed emergencies while better aligning state activities with a national integrated animal feed safety system, thereby achieving the overall goal of protecting public health by assuring food and feed commodities are safe for commerce.

PI_NAMEs: KENNEDY, RACHELLE  (contact)

PROJECT_TITLE: California Department of Food and Agriculture AFRPS Maintenance and PC Option


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This resource application proposes the integration of dictyBase, the genomic resource for the eukaryote Dictyostelium discoideum and related species, and the Dicty Stock Center to create the Dictyostelium Community Resource. Dictyostelium is widely used for research in the biomedical, genetic, and environmental domains. This new community resource will serve as a one stop shop for integrated biological knowledge organized around the genome that will allow investigators to obtain strains, expression vectors and other valuable materials through simple searches of the DCR.

PI_NAMEs: CHISHOLM, REX L (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Bar Codes;Biological;Biomedical Research;Birds;Caring;Cell Differentiation process;cell motility;Cell Physiology;Chemotaxis;Cloning;cloud based;Collaborations;Collection;Communication;Communities;community engagement;comparative;comparative genomics;contig;dashboard;Data;data curation;Data Display;data integration;Data Storage and Retrieval;Dictyostelium;Dictyostelium discoideum;Disease;diverse data;Electronic Mail;Equipment and supply inventories;Eukaryota;expression vector;Eye;Family;Fostering;Friends;Funding;Genbank;gene product;Genes;Genetic;Genome;genome annotation;genome browser;genome resource;Genomics;Goals;Hour;human disease;improved;Individual;Infrastructure;instructor;interest;Internet;Intuition;Knowledge;Literature;Location;Maps;Methods;microbial;migration;Mission;model organisms databases;Modeling;Molecular;mutant;new technology;Newsletter;Nomenclature;novel;online resource;Ontology;operation;Organism;Orthologous Gene;outreach;pathogen;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasmids;preservation;Procedures;Proteins;Protocols documentation;Publications;Publishing;Quality Control;Records;reference genome;repository;Research;Research Personnel;Research Support;Resources;response;Role;Running;search engine;Secure;Signal Transduction;Site;System;Taxonomy;teacher;Teaching Materials;Telephone;Time;tool;Training;Trust;United States National Institutes of Health;Update;user-friendly;Yeasts

PROJECT_TITLE: Dictyostelium Community Resource


ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This project aims at defining mechanisms responsible for the formation and maintenance of the neuromuscular junction (NMJ), and the survival of motor neurons. This is important because abnormal formation or function of the NMJ, as well as the loss of motor neuron, is implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Therefore, identifying regulatory mechanisms responsible for structural and functional changes in the NMJ will enable us to improve current treatment strategies for neurodegenerative diseases such as ALS.

PI_NAMEs: LIN, WEICHUN  (contact);ROTHERMEL, BEVERLY A

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Address;Alleles;Amyotrophic Lateral Sclerosis;Anabolism;autism spectrum disorder;Binding;Calcineurin;Cells;Central Nervous System;Choline Deficiency;Choline O-Acetyltransferase;Cholinergic Receptors;cholinergic synapse;Coupling;Cre driver;Cysteine-Rich Domain;Data;Defect;Development;Dihydropyridine Receptors;Elements;Embryo;Enzymes;Equilibrium;experimental study;Feedback;Foundations;Future;Gene Deletion;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;improved;insight;Investigation;Knowledge;Location;LoxP-flanked allele;Maintenance;Mediating;Mental Retardation;Modeling;Molecular;Motor;Motor Neurons;Mus;Muscle;Muscle Fibers;myocyte-specific enhancer-binding factor 2;Nerve;nerve supply;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuromuscular;neuromuscular function;Neuromuscular Junction;neuron loss;neuronal survival;Neurons;Neurotransmitters;nuclear factors of activated T-cells;Pathway interactions;Pattern;Peripheral;Phenotype;Play;postnatal;postnatal development;postsynaptic;presynaptic;prevent;Prevention;Protein Isoforms;Protein phosphatase;Proteins;Proteomics;Regulation;Research Project Grants;Role;Ryanodine Receptor Calcium Release Channel;Schwann Cells;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Site;Skeletal Muscle;Striated Muscles;Structure;Synapses;synaptogenesis;therapeutic development;therapeutically effective;tool;trafficking;transcription factor;Transgenic Mice;treatment strategy

PROJECT_TITLE: Patterning and Formation of the Neuromuscular Junction

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The opportunity to treat obesity and reverse weight-related complications remains untapped. The proposed research will test the effectiveness and implementation of a novel, scalable, highly pragmatic approach to weight management in primary care: PATHWEIGH. PATHWEIGH optimizes existing resources more efficiently to overcome barriers and mainstream weight management in routine medical practice.

PI_NAMEs: HOLTROP, JODI SUMMERS;PERREAULT, LEIGH  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Body Weight decreased;Clinic;Clinical Data;Cluster randomized trial;Colorado;Communities;comorbidity;Complex;contextual factors;cost;Cost Analysis;Data;Data Analyses;Data Collection;Diagnosis;Disease;Education;Effectiveness;effectiveness testing;effectiveness/implementation hybrid;electronic medical record system;Epidemic;evidence base;Family;Family health status;Family Practice;Glucose;Health;hybrid type 1 study;implementation evaluation;implementation strategy;improved;innovation;Insurance Carriers;Internal Medicine;Intervention;Interview;Life Style;Mainstreaming;Maintenance;Mediator;Medical;Methods;Modeling;multilevel analysis;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity management;Outcome;Overweight;patient population;Patients;Persons;Pilot Projects;Practical Robust Implementation and Sustainability Model;practice setting;preventable death;Primary Care;primary care clinic;Process;Provider;Randomized;Recommendation;Recording of previous events;Research;Resources;Risk Factors;service delivery;Site;Smoking;standard of care;success;Surveys;System;Testing;Time;tool;Training;trial design;United States;Universities;Visit;Weight;Weight Gain;Weight maintenance regimen;Work

PROJECT_TITLE: PATHWEIGH: pragmatic weight management in primary care


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Prevention

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer’s Disease Study (D-PRESCRIBE-AD) will represent the first rigorous evaluation of a large scale, health plan-based, educational intervention to improve medication safety and reduce the occurrence of preventable medication-related morbidity among high-risk patients with Alzheimer’s disease and Alzheimer’s disease-related dementias. By design, the proposed intervention will be readily transportable to other large health plans and healthcare systems.

PI_NAMEs: GURWITZ, JERRY H (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adverse drug event;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Anti-Cholinergics;Antipsychotic Agents;arm;caregiver education;Caregivers;Categories;Cluster randomized trial;collaboratory;Communication;Communities;comorbidity;comparative effectiveness;Data;Decision Making;design;Drops;Education;Educational Intervention;Educational Materials;Effectiveness;Elderly;Electronic Health Record;Emergency department visit;Emergency Situation;Enrollment;Evaluation;expectation;experience;falls;Future;Goals;health care service utilization;Health Personnel;health plan;health related quality of life;Health system;Healthcare Systems;High Prevalence;high risk;Hospitalization;hospitalization rates;hypnotic;Hypoglycemia;Impaired cognition;implementation science;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;Intervention;Intervention Trial;medication safety;Morbidity - disease rate;mortality;multiple chronic conditions;older adult;Oral;Outcome;Outcome Study;Outpatients;Participant;Patient Care;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Polypharmacy;Population;Pragmatic clinical trial;pragmatic trial;Prevalence;primary outcome;Procedures;programs;prospective;Provider;provider communication;Randomized;Research;Research Design;Risk;scale up;secondary outcome;sedative;Sentinel;Skilled Nursing Facilities;Specific qualifier value;study population;Symptom Burden;Testing;therapy design;treatment as usual;trial design;United States Food and Drug Administration;United States National Institutes of Health;Visit;Vulnerable Populations

PROJECT_TITLE: Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease Study (D-PRESCRIBE-AD)


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Pathologists are experts in making a diagnosis of cancer and describing the microscopic features that help guide treatment decisions. Computers are rapidly catching up to pathologists, and this study compares how new computer methods that recognize how the body's immune system reacts to colorectal cancer perform against expert pathologists. It is also possible to directly measure immune reactions and map these to specific locations inside the tumor; together with information about age, sex, and a person's genetics and history, the goal of this study is to improve predictions of survival and to automate the diagnosis colorectal cancer.

PI_NAMEs: GRUBER, STEPHEN B (contact)

PROJECT_TERMS: accurate diagnosis;Address;Age;Algorithms;Artificial Intelligence;California;cancer diagnosis;Cancer Prognosis;cancer survival;CD3 Antigens;CD8-Positive T-Lymphocytes;Characteristics;Clinical;Clinical Data;clinical predictors;clinically relevant;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Computers;Computing Methodologies;Crohn's disease;Data;deep learning;design;Detection;Diagnosis;digital;digital data;digital imaging;driver mutation;effective therapy;Ensure;epidemiologic data;Epidemiology;ethnic diversity;Expression Profiling;Failure;Florida;Genetic;Germ Lines;Goals;Histology;Image;Image Analysis;Immune;Immune response;Immune system;Immunologics;Immunology;immunoreaction;immunoregulation;Immunotherapy;improved;improved outcome;insight;Israel;Location;low income country;Lymphocyte;Lymphoid;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Maps;Measures;medical specialties;Methods;Microsatellite Instability;Microscopic;Modeling;Molecular;New York;novel;Other Genetics;Outcome;Pathologic;Pathologist;Pathology;Patients;Pattern;Performance;Persons;Physicians;Population;Population Heterogeneity;prediction algorithm;predictive modeling;Predictive Value;Process;Prognosis;prognostic;prognostic model;prognostic value;protein expression;Proteins;Puerto Rico;racial diversity;Reaction;Recording of previous events;Reproducibility;Research;response;Sampling;sex;Slide;Solid Neoplasm;Spain;Spatial Distribution;Specimen;statistical and machine learning;Statistical Methods;survival prediction;System;task analysis;Technology;Testing;TNM;tool;Training;treatment response;tumor;Tumor-Infiltrating Lymphocytes;Validation;Visual;whole slide imaging

PROJECT_TITLE: Integration of epidemiology, pathology, immunology and outcomes in colorectal cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Infectious Diseases;Lung;Mental Health;Nutrition;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SOUTHERN METHODIST UNIVERSITY

PHR: Project Narrative Currently, there is a lack of evidence-based prevention strategies for respiratory infection and management of these conditions can be costly to the public. Airway nitric oxide provides a first line of defense against pathogens, and beetroot juice, a source of dietary nitrate, has been shown to elevate nitric oxide. The main objective of this project is to demonstrate that one week of supplementation with beetroot juice elevates airway nitric oxide during stressful periods in young adults and thereby can protect against respiratory viral infections.

PI_NAMEs: RITZ, THOMAS EKKEHARD (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Absenteeism at work;Adherence;Adverse effects;arginase;arm;Attenuated;Biological;Buffers;Cardiovascular system;Cellular Phone;Cessation of life;Chronic stress;Clinical Trials;Common Cold;cost;COVID-19;Cytostatics;cytotoxic;Data;Defense Mechanisms;Dependence;Developed Countries;Development;Dietary Intervention;dietary nitrate;dosage;Dose;Double-Blind Method;double-blind placebo controlled trial;Economic Burden;Epithelial Cells;evidence base;Exercise Physiology;Exhalation;experience;Feasibility Studies;follow up assessment;Healthcare Systems;Hour;Human;Hydrocortisone;Infection;infection risk;inhibitor;insight;Intake;Intervention;Juice;Life Stress;Link;Lung;Measures;Mediation;Medicine;Mental Depression;Monitor;Mucosal Immunity;N,N-dimethylarginine;Nitrates;Nitric Oxide;Nitric Oxide Pathway;Nitrites;novel;novel strategies;Outcome;Outcome Assessment;Participant;pathogen;Patient Recruitments;Placebo Control;placebo controlled trial;Placebos;Polymerase Chain Reaction;Population;Predisposition;Prevention;Prevention approach;Prevention strategy;Preventive treatment;Procedures;Production;Productivity;Property;prophylactic;Protein Secretion;Protocols documentation;Psychological Factors;Psychological Stress;Psychosocial Factor;Psychosocial Stress;public health relevance;Randomized Controlled Clinical Trials;randomized, clinical trials;recruit;reduce symptoms;Reporting;Research;respiratory;Respiratory Mucosa;Respiratory Tract Infections;Rhinovirus infection;Risk;Sampling;Severities;sex;Signal Transduction;Site;Social support;Societies;Source;Stress;Students;Supplementation;Symptoms;Testing;Tissues;transmission process;trial design;Universities;Video Recording;Viral;Viral Respiratory Tract Infection;Virus Diseases;virus testing;Visit;young adult

PROJECT_TITLE: Beetroot Juice Supplement for Boosting Mucosal Immunity – The NO Cold Study


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: * * * * NARRATIVE * * * * The principal goals of the Genome Data Analysis Center (GDAC) proposed here are (i) to perform batch effects identification, quantitation, diagnosis, and (when appropriate) correction, proactively and as requested by the Network; (ii) to contribute when useful to integrated cluster analysis, RPPA proteomic data analysis, and high- level interactive visualization of omic data (including single-cell sequencing data); (iii) to communicate results to other network members, project stakeholders, and the scientific community. The GDAC will primarily support projects managed by the Center for Cancer Genomics (CCG), whose principal goal is better understanding of the biology of cancer and mechanisms of resistance to therapy.

PI_NAMEs: AKBANI, REHAN  (contact);BROOM, BRADLEY MCINTOSH;WEINSTEIN, JOHN N

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Algorithms;Atlases;Back;Bioinformatics;bioinformatics tool;Biological;Biology;Biometry;Cancer Biology;Cancer Center;cancer genomics;Cells;Clinical;Cluster Analysis;Collaborations;Communication;Communities;Competence;Complex;Computational Biology;Computer software;computerized tools;Computing Methodologies;computing resources;Consult;Consultations;Data;Data Analyses;data integration;Data Set;Dedications;Detection;Development;Diagnosis;Disease;Doctor of Philosophy;experience;Experimental Designs;Faculty;FAIR principles;Future;Generations;Genome Data Analysis Center;Goals;innovation;Institution;Instruction;interactive visualization;Laboratory Research;Leadership;Malignant Neoplasms;Medicine;member;Methodology;Mission;Modeling;Molecular Profiling;molecular scale;Morphologic artifacts;multidisciplinary;multiple omics;Pathway interactions;Phase;prevent;Process;programs;Protein Array;Protein Array Analysis;Proteomics;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;resistance mechanism;Sampling;Schedule;segregation;single cell sequencing;Software Engineering;software systems;surveillance data;System;The Cancer Genome Atlas;therapy resistant;Time;tool;Translating;trend;tumor;Visualization;Work;working group

PROJECT_TITLE: A Genome Data Analysis Center Focused on Batch Effect Analysis and Data Integration


ADMINISTERING_IC: TR

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The Oregon Clinical and Translational Research Institute builds a diverse workforce of researchers who are  committed to improving the health of people in Oregon and beyond. It reduces obstacles that slow the  translation of ideas into impact. It builds relationships with communities to ensure that research is relevant and  useful.

PI_NAMEs: MORRIS, CYNTHIA D (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;Address;Articulation;base;Biometry;Businesses;Clinical;Clinical Research;cohort;Collaborations;Communities;community engagement;Community Hospitals;Competence;COVID-19;COVID-19 pandemic;Data;data sharing;data warehouse;Democracy;Development;Diverse Workforce;Ecosystem;Education;Electronics;Ensure;Equity;Evaluation;Fast Healthcare Interoperability Resources;Fostering;Funding;Goals;Health;Healthcare;improved;Informatics;innovation;Leadership;Link;Malignant Neoplasms;member;Methods;metropolitan;Modeling;National Center for Advancing Translational Sciences;novel;novel strategies;novel therapeutics;Oregon;Outcome;Participant;Patients;Persons;Process;programs;Research;Research Institute;Research Personnel;Resources;Role;Rural;Science;Services;social health determinants;Special Population;Speed;Structure;success;System;Testing;Time;Training;Training Programs;Translating;Translational Research;Translations;Trust;Underserved Population;Universities;Voice;Workforce Development


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: NARRATIVE Host immune systems are a double-edged sword—both protecting the host, but also bringing to bear dangerous weapons that cause self-inflicted damage. For bacteria that can infect a host without causing significant damage, it may be important to control the immune response to limit self-inflicted damage; mutations that result in loss of control of the inflammation can result in persistent symptoms. We are exploring a mutation in a human innate immune receptor, toll-like receptor 1, that results in increased inflammatory responses in patients infected with the Lyme disease bacteria, Borrelia burgdorferi.

PI_NAMEs: HU, LINDEN T (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acute infection;Affect;Amino Acids;Animals;Antibiotic Therapy;Arthritis;Bacteria;Belief;Biological Assay;Borrelia burgdorferi;Carditis;Cell Death;Cell Line;Cell surface;cell type;Cells;Clinical;Collaborations;Confocal Microscopy;cytokine;Dangerousness;Data;Defect;Development;Disease;Endosomes;Exanthema;Exhibits;experimental study;Exposure to;Failure;Fatigue;flu;Genes;genome sequencing;glucose metabolism;Health;Heterodimerization;Hour;Human;Human Genetics;Immune;immune clearance;Immune response;Immune system;Immune Tolerance;Immunologic Receptors;In Vitro;in vivo;Inbred Mouse;individual patient;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;Isoleucine;Knock-out;Laboratories;Life;Ligands;Link;Lipoproteins;Location;Lyme Arthritis;Lyme Disease;Macrophage;Measures;Mediating;Meningitis;Metabolism;Modeling;mouse model;Movement;mutant;Mutation;Natural Immunity;Neurocognitive;Organism;Pain;pathogen;Pathway interactions;Patients;persistent symptom;Process;Reaction;receptor;receptor expression;Reporting;Research Personnel;response;Risk;Role;Serine;Signal Pathway;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;Site;Stimulus;Symptoms;Syndrome;Testing;Time;TLR1 gene;TLR2 gene;trafficking;Vector-transmitted infectious disease;weapons

PROJECT_TITLE: Role of human innate immune mutations in loss of tolerance to Borrelia burgdorferi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-V(02)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Parkinson’s disease (PD) pathogenesis has pointed to a key role for the endolysosomal system. However, the contribution to disease etiology of VPS13C (Vacuolar Protein Sorting 13 Homolog C), a newly identified PD gene with links to the endolysosomal pathways, is not well understood. This work will elucidate the mechanistic basis of VPS13C in neuronal function to ultimately identify potential therapeutic targets for PD.

PI_NAMEs: CARAVEOPISO, GABRIELA  (contact);KRAINC, DIMITRI

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Affinity Chromatography;aging population;alpha synuclein;Autophagocytosis;Autophagosome;autosome;Binding Proteins;Biogenesis;Calcineurin;calcineurin phosphatase;Calcium;Cells;Coupled;CRISPR/Cas technology;Cytosol;Data;Defect;Disease;disease model;Disease Progression;Dopamine;dopaminergic neuron;early onset;Electron Microscopy;Emotional;Endoplasmic Reticulum;Etiology;Functional dependence;Functional disorder;Genes;Genetic;Goals;Homeostasis;Homologous Gene;Human;human induced pluripotent stem cells;Image;imaging facilities;imaging modality;Imaging Techniques;Impaired cognition;Individual;induced pluripotent stem cell;insight;Investigation;Knock-out;Lewy Bodies;Lewy body pathology;Link;Lipid Binding;lipid transport;Lipids;live cell imaging;loss of function;Lysosomes;Mass Spectrum Analysis;Mediating;Mediator;Microscopy;Midbrain structure;Mitochondria;Modeling;Morphology;Mutation;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel therapeutics;Organelles;oxidation;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation Site;Protein Dephosphorylation;Protein Truncation;receptor;Regulation;Reporter;Research;Role;sensor;Signal Transduction;Site;SNAP receptor;Societies;Stress;Structure;superresolution microscopy;System;Testing;therapeutic target;Time;Toxic effect;Universities;Vacuolar Protein Sorting;Variant;Work

PROJECT_TITLE: Neuronal roles of Parkinsons Disease Vps13C in regulating autophagy and calcium dynamics

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: As the threat of infectious diseases expands, there is a greater need than ever for veterinarians who are trained as scientists working at the intersection between medicine and science. The goal of the Penn VMD-PhD training program in infectious disease-related research is to identify, train, and mentor a diverse group of outstanding women and men to become scholars and leaders of biomedical research in infectious disease-related topics.

PI_NAMEs: ATCHISON, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Doctor of Philosophy;Research;Training

PROJECT_TITLE: VMD-PhD Training in Infectious Disease-Related Research

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE  New chemical tools and drug modalities are urgently needed to dissect and target the pathologic protein interactions that drive human cancer. We synthesize and deploy hydrocarbon-stapled peptides, which recapitulate the shape, stability, and bioactivity of natural a-helical interaction motifs, to interrogate the biochemistry, structural biology, proteomics, and cell biology of cancer-causing proteins. By applying stapled peptides in a diversity of cancer projects that span deregulated apoptosis, transcription, and metabolism, we are committed to achieving fresh insight into fundamental oncogenic mechanisms and to advancing new treatments for cancer patients.

PI_NAMEs: BIRD, GREGORY HOWARD (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Adult;Affinity;alpha helix;analog;anti-cancer research;Apoptosis;Apoptotic;BCL1 Oncogene;Binding;Binding Sites;Biochemistry;Biology;Cancer Biology;cancer cell;Cancer Patient;Cancer Relapse;Cancer Research Project;cancer therapy;Cellular biology;cellular imaging;Cessation of life;Chemicals;Chemistry;Chemoresistance;Child;Clinical Trials;Consultations;Cysteine;design;Development;Equilibrium;Family;Funding;Genetic Transcription;Goals;Human;Hydrocarbons;in vivo imaging;innovation;insight;Investigational Therapies;Life;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Metabolism;Mining;Mitochondria;Modality;next generation;novel therapeutics;Oncogenic;overexpression;Pathologic;Pediatric Oncologist;Pharmaceutical Preparations;Preclinical Testing;Production;programs;Protein Family;Proteins;Proteomics;prototype;Radiolabeled;Reagent;Research;Running;Shapes;Signal Transduction;Specialist;Spin Labels;stapled peptide;structural biology;Surface;Therapeutic;therapeutic development;therapeutic target;tool;Translations;Variant

PROJECT_TITLE: Stapled Peptides for Protein Interaction Research and Therapeutic Targeting in Human Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Dementia;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Apathy, as one of the top ranked symptoms of both Alzheimer’s disease (AD) and maternal alcohol consumption, has been understudied but significantly affects the life of patients and caregivers. The goal of this project is to uncover a potential novel target, an atypical excitatory receptor in the nucleus accumbens, a brain region associated with motivational output, in those prenatally exposed to alcohol and also having high risk for AD. This may significantly improve the life quality of AD patients, decrease caregiver burden, lower the cost of care, and minimize premature institutionalization.

PI_NAMEs: MA, YAO-YING  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;Age;alcohol exposure;Alcohol-Related Disorders;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;AMPA Receptors;antagonist;associated symptom;Atrophic;Attention;behavior test;Behavioral;behavioral phenotyping;Biochemical;Brain;Brain region;care costs;Caregiver Burden;Caregivers;Cells;Clinic;Cocaine;Data;Dementia;design;disabled;Disease;early onset;Early Onset Alzheimer Disease;Elderly;Environmental Risk Factor;Evaluation;Excitatory Synapse;excitotoxicity;exposed human population;Fetal alcohol effects;Fetal Alcohol Exposure;foot;Genetic;Glutamates;Goals;high risk;Hippocampus;Housing;Human;Impaired cognition;improved;in vivo;Incidence;indexing;Institutionalization;Investigation;Laboratory Animals;Learning;Life;Life Expectancy;Light;Live Birth;Locomotion;maternal alcohol use;Measures;Medial;Mediating;Membrane Proteins;Memory;Mental disability;middle age;Molecular;Motivation;Neurobiology;Neurons;neuropsychiatric symptom;novel;Nucleus Accumbens;Optics;optogenetics;Output;patch clamp;Pathologic;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;postsynaptic;Prefrontal Cortex;premature;presynaptic;presynaptic density protein 95;Prevalence;prevent;protective factors;Psyche structure;Psychological reinforcement;Quality of life;Rattus;receptor;Recording of previous events;recruit;Reporting;risk variant;Role;Shock;Slice;Stains;success;Sucrose;Symptoms;Synapses;Synaptic Transmission;Testing;Transgenic Organisms;United States;Vertebral column;vesicular glutamate transporter 1;Western Blotting

PROJECT_TITLE: Effects of Prenatal Alcohol Exposure on Alzheimer's Disease-associated Neuropsychiatric Symptoms


ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE: OVERALL The well-established Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) triad provides an exceptional environment to identify and address health care inequities in cancer seen in underrepresented minorities. The proposed research projects, cores, and shared resource cores will grow research and propose evidence-based solutions address to these inequities. Further, the development of expanded research infrastructure at MMC and TSU, enhancement of minority education programs, and improvement to the effectiveness of cancer-related activities will address health care disparities in the greater Nashville geographical region, with the ultimate goal of contributing to reducing health disparities among cancer patients in minority and underserved communities.

PI_NAMEs: ADUNYAH, SAMUEL EVANS (contact);STEWART, LAMONICA VANETTE

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Awareness;Basic Science;Behavioral;Big Data;Bioinformatics;Bioinformatics Shared Resource;Biological Factors;Biometry;Cancer Center;cancer clinical trial;cancer health disparity;cancer initiation;Cancer Patient;Cancer Research Project;career;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative approach;Colorectal Cancer;Communities;Community Health;community organizations;community research;Comprehensive Cancer Center;Death Rate;Development;Discipline;Disparity;Education;education research;Effectiveness;Environment;Equity;Ethnic Origin;Evaluation;evidence base;Extramural Activities;Faculty;Financial Hardship;Fostering;Geographic Locations;Geography;Goals;graduate student;Growth;health care disparity;Health Educators;high school;Immunooncology;improved;Incidence;Inequity;Infrastructure;Institution;Intervention Trial;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority;minority communities;Minority-Serving Institution;Mission;mortality;multidisciplinary;Oncology;Outcome;outcome disparities;outreach;outreach program;Pathology;Pathway interactions;Patient Participation;Peer Review;Population Research;Population Sciences;Prevalence;programs;Publications;Race;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;screening;Series;socioeconomics;survivorship;Tennessee;Training;Translational Research;treatment trial;undergraduate student;Underrepresented Minority;underserved community;United States;Universities

PROJECT_TITLE: 1/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities


ORG_DEPT: GENETICS

PHR: Project Narrative Challenges with delivery, specificity, and immunogenicity in current gene editing technologies have hindered efforts to correct genetic disease mutations in vivo, especially beyond the liver. This proposal seeks to develop and validate new base editors, delivery vehicles, and safety enhancements, and to apply them to mouse models of central nervous system disease. These studies will enhance the efficacy and safety of in vivo genome editing capabilities of base editors and other CRISPR tools.

PI_NAMEs: SONTHEIMER, ERIK J. (contact);XUE, WEN

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adenine;adenovirus mediated delivery;Adverse effects;adverse outcome;Alleles;Amyotrophic Lateral Sclerosis;base editing;base editor;cell type;Central Nervous System;Central Nervous System Diseases;Clinical;clinical practice;CLN3 gene;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytidine;Deaminase;delivery vehicle;Dendritic Cells;density;Deoxyribonucleases;Dependovirus;Development;Dinucleoside Phosphates;Disease;disease model;disease-causing mutation;DNA Sequence Alteration;Effectiveness;Endowment;exon skipping therapy;Exons;Extrahepatic;gene editing technology;Genes;Genetic Diseases;genome editing;Goals;Hepatic Tissue;Hepatocyte;Hepatotoxicity;humanized mouse;Immune response;Immunity;immunogenicity;improved;in vivo;Interphase Cell;knockout gene;Knowledge;Liver;Mammalian Cell;MicroRNAs;Modality;mouse model;Mus;Mutagenesis;mutant;Mutate;Mutation;next generation;novel;Nucleotides;Patients;Pharmaceutical Preparations;prevent;prime editing;repaired;Repression;Research;Risk;RNA;RNA Splicing;Safety;Site;Specificity;Spielmeyer-Vogt Disease;Spinal Ganglia;superoxide dismutase 1;System;Testing;Therapeutic;therapeutic genome editing;Tissues;Toxic effect;vector

PROJECT_TITLE: Advanced Delivery Platforms for Base Editing In Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(02)M]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ADUNYAH, SAMUEL EVANS (contact)

PROJECT_TERMS: Advisory Committees;Annual Reports;anti-cancer research;Basic Science;Belief;Cancer Center;cancer health disparity;career development;Clinical;Clinical Sciences;Collaborations;Communication;Community Outreach;Data;Disparity;Doctor of Philosophy;Educational workshop;Ensure;Ethnic Origin;Evaluation;Expenditure;experience;Faculty;faculty mentor;Faculty Recruitment;Fostering;Funding;Funding Agency;Funding Opportunities;Geography;Goals;Growth and Development function;Guidelines;Human Resources;implementation strategy;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;medical schools;Mentorship;Mission;Monitor;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;Phase;Population Sciences;Preparation;Principal Investigator;Process;Productivity;programs;Progress Reports;Race;recruit;Regulation;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;Services;Socioeconomic Status;Strategic vision;symposium;synergism;Tennessee;Training and Education;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: MMC Admin Core


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Kidney Disease;Neurodegenerative;Neurosciences;Pediatric;Peripheral Neuropathy;Polycystic Kidney Disease

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because the formation of macromolecular structures at the plasma membrane is crucial for cell and tissue homeostasis, structure and function. Defects in the composition of these structures lead to a wide variety of diseases such as cancer, neurodegenerative diseases such as alzheimers, ciliopathies such as polycystic kidney disease, and others. This proposal uses a novel model system and an innovative microfluidic cell-like approach in conjunction with optogenetics to uncover the role of newly identified proteins in the formation of macromolecular complexes.

PI_NAMEs: BROWNLEE, CHRISTOPHER WILLIAM (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;alpha Karyopherins;Alzheimer's Disease;Biochemical;Biological;Biological Models;Cell Cycle;Cell division;Cell membrane;Cell surface;cell type;Cells;ciliopathy;Complex;Cytoplasm;Defect;Diagnostic;Disease;Dissection;Encapsulated;Goals;Growth;Homeostasis;innovation;Lead;Location;Macromolecular Complexes;Malignant Neoplasms;Membrane;Microfluidics;Molecular Structure;Neurodegenerative Disorders;Neuropathy;neurotransmission;new therapeutic target;novel;novel diagnostics;optogenetics;Pathway interactions;Polycystic Kidney Diseases;Proteins;Public Health;Research;Research Personnel;Resources;Role;Science;Signal Transduction;Structure;Techniques;therapeutic target;Tissues;Work

PROJECT_TITLE: Dissecting the Diverse Roles of Importin α at the Plasma Membrane

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: MARSHALL, DANA ROBIN (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;Cancer Center;cancer health disparity;Cancer health equity;Collaborations;Collection;Communication;Data;Data Analyses;Data Collection;data management;Data Reporting;Decision Making;design;Development;Education;Ensure;Evaluation;Feedback;Fostering;Funding;Goals;Grant;Health;health inequalities;improved;innovation;Institution;Investments;Leadership;Logic;Malignant Neoplasms;Measurable;Measures;medical schools;Methods;Modeling;Monitor;Nature;Outcome;Output;Performance;Practice Management;Principal Investigator;Process;Program Evaluation;programs;Publications;Quality of life;Recommendation;recruit;Research;Research Personnel;Resources;Respondent;Services;Students;success;Teacher Professional Development;Techniques;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;Time;tool;Universities;Work

PROJECT_TITLE: Planning/Evaluation Core


ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative Production of small molecules that bind metal ions is important for the survival of microbes and the ability of these microbes to cause infections. We study the reaction mechanisms of the enzymes responsible for the production of a unique copper-containing antibiotic, which is produced by a pathogen that can cause serious hospital-acquired infections. Our mechanistic investigations will advance the understanding of enzyme-catalyzed reactions, provide new tools for biocatalysis, and enable studies of how pathogenic bacteria maintain copper balance during infection.

PI_NAMEs: LI, BO  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;adenylosuccinate lyase;Amines;Anabolism;analog;Antibiotics;Binding;Biomedical Engineering;Carbon;carboxylate;Catalysis;Chemical Structure;Chemistry;Collaborations;college;Copper;Cysteine;Data;Decarboxylation;Dioxygenases;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Engineering;Enzyme Kinetics;enzyme mechanism;Enzymes;Equilibrium;Excision;Exhibits;Family;fluopsin;Formates;Fumarates;Heme;human pathogen;Hydrogen;Industrialization;Infection;innovation;insight;Investigation;Ions;Iron;Lifting;Ligand Binding;Ligands;Lyase;Medicine;Metal Ion Binding;Metals;Microbe;microorganism;Monitor;Multi-Drug Resistance;N hydroxylation;Natural Products;Nature;Nitric Oxide;Nosocomial Infections;novel;Oximes;Oxygen;Oxygenases;pathogen;pathogenic bacteria;Pathway interactions;Pharmacologic Substance;Play;Production;Pseudomonas aeruginosa;Reaction;Recycling;Reducing Agents;Roentgen Rays;Siderophores;small molecule;Spectrum Analysis;stoichiometry;structural biology;Structure;Sulfur;Synthesis Chemistry;synthetic biology;Testing;tool;Variant;Virulence;Work

PROJECT_TITLE: Mechanisms of unusual enzymes in the biosynthesis of a copper-containing antibiotic

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Social Determinants of Health

PROJECT_TERMS: African American;American;anti-cancer research;Biology;Cancer Biology;Cancer Center;cancer health disparity;career;Career Choice;career development;Chemistry;Clinical;Cognitive;Communities;Community Developments;Community of Practice;Development;Disparity;Doctor of Philosophy;doctoral student;education research;Educational workshop;Ensure;Environment;Evolution;experience;faculty mentor;Goals;graduate student;Growth and Development function;high school;High School Student;innovation;Institution;interest;Laboratory Research;Latinx;learning materials;Maintenance;Malignant Neoplasms;Master of Public Health;medical schools;Medical Students;Mentors;Pathway interactions;peer coaching;Population;Population Heterogeneity;Population Sciences;programs;Psychosocial Assessment and Care;psychosocial resources;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Self Efficacy;Series;social;student participation;Students;success;Talents;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;Training and Education;translational cancer research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities

PROJECT_TITLE: Education and Training Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The accelerated growth of research data of increasing volume and complexity is profoundly transforming biomedical research, allowing scientists to ask new research questions and address emerging disease scenarios. We will further develop our literature mining system with an automated workflow for extraction of scientific knowledge across the bibliome, along with semantic integration of biomedical data for computational reasoning in an inferable and explainable knowledge system. The combined effort will aid in improving understanding of human disease and identification of potential drug targets for major health conditions like Alzheimer's Disease or urgent pandemics such as COVID-19.

PI_NAMEs: WU, CATHY H. (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Adopted;Alzheimer's Disease;Applications Grants;bioinformatics infrastructure;Biomedical Research;Case Study;Code;Communities;community engagement;Computational algorithm;computational reasoning;Computer Systems;COVID-19;Data;data modeling;Databases;deep learning;Disease;drug repurposing;Drug Targeting;Educational workshop;Ensure;FAIR principles;Fostering;fundamental research;Generations;Genes;Genotype;Growth;hackathon;Health;Human;human disease;improved;Information Retrieval;Knowledge;Knowledge Discovery;knowledge network;Link;Literature;Machine Learning;Mining;Modeling;Modification;Morphologic artifacts;Natural Language Processing;Ontology;Organism;pandemic disease;Pharmaceutical Preparations;Phenotype;Post-Translational Protein Processing;Protein Analysis;Proteins;Reproducibility;Research;Resource Description Framework;Resource Sharing;Resources;Scientist;Semantics;System;Systems Development;Text;text searching;tool;Training;Variant;web site

PROJECT_TITLE: Protein Knowledge Networks and Semantic Computing for Disease Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The accurate and complete replication of chromosomal DNA is essential to maintain cell identity and prevent genome changes that lead to cancer and developmental defects. We are using novel assays that recapitulate the earliest event in this process to understand how the molecular machines that perform chromosomal DNA replication are assembled.

PI_NAMEs: BELL, STEPHEN P. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Bypass;Cell Cycle;Cell division;Cells;Chromosomes;Collaborations;Complement;Complex;Cryoelectron Microscopy;Defect;Deposition;Development;DNA;DNA Binding;DNA biosynthesis;DNA replication fork;DNA replication origin;Elements;Ensure;Eukaryotic Cell;Event;Experimental Genetics;experimental study;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;G1 Phase;Genome;genome integrity;Genomic Instability;Head;helicase;Human;In Vitro;in vivo;Individual;insight;Kinetics;Lead;Licensing;Maintenance;Malignant Neoplasms;Mediating;Molecular;Molecular Biology;Molecular Genetics;Molecular Machines;Monitor;mutant;Mutation;N-terminal;Nature;novel;Nucleosomes;Organism;origin recognition complex;Pathway interactions;prevent;Process;Productivity;protein protein interaction;Proteins;Reaction;reconstitution;recruit;Regulation;Replication Initiation;Replication Origin;Research;Role;S phase;Saccharomycetales;Shapes;single molecule;Site;Specificity;Structure;targeted treatment;Techniques;Testing;Time;tool;tumorigenesis;yeast protein;Yeasts

PROJECT_TITLE: Mechanisms of replication origin licensing studied by real-time single-molecule fluorescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: ERVES, JENNIFER C. (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Affect;anti-cancer research;Applications Grants;Area;biobank;Bioinformatics Shared Resource;Biometry;Black race;Breast Cancer Risk Factor;Cancer Burden;cancer care;Cancer Center;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Censuses;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community building;community collaboration;community engaged research;community engagement;community organizations;Community Outreach;community partners;community research;County;design;Development;Dissemination and Implementation;dissemination science;Education and Outreach;education research;Educational Materials;Ensure;Equity;ethnic minority;Evaluation;evidence base;Faculty;Feedback;Fostering;Foundations;Funding;Goals;Grant;health equity;Health equity research;health inequalities;Healthcare;implementation science;innovation;Institution;interest;Knowledge;Learning;Learning Module;Maintenance;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;meetings;member;men;Mentorship;Methodology;metropolitan;Minority Participation;mobile application;mortality disparity;Multicultural Education;new technology;online resource;outreach;Outreach Research;Ownership;Participant;Pathology;Patients;Pilot Projects;Policies;Population;Population Research;Prevention;Process;programs;Public Health Education;racial minority;Research;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Risk Assessment;Rural Community;Scanning;social media;Source;Students;Support Groups;survivorship;Technology;Tennessee;Testing;Training Activity;training opportunity;underserved community;Universities;web-based tool;Work

PROJECT_TITLE: Cancer Community Outreach Core


NIH_SPENDING_CATS: Aging;Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Pain Research;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE  Low back pain is the most disabling condition in the world for older adults, and current clinical outcomes for this population are suboptimal. Stress reactivity is an acute physiologic stress response that is linked to disease and disability in other populations, but is understudied in older adults with low back pain. This proposal will build upon pilot data to quantify stress reactivity in older adults with low back pain, and will subsequently develop a biobehavioral intervention targeting high stress reactivity to reduce disability risks.

PI_NAMEs: SIMON, COREY  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acute;Address;Adrenal Glands;Affect;Aging;Behavior Therapy;Behavioral Model;biobehavior;biological adaptation to stress;Biological Markers;Blood;Capsicum;Cardiovascular Diseases;career;career development;Career Mobility;Chronic;Chronic disability;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Cohort Studies;coping;Coping Behavior;Coping Skills;cytokine;Data;Dedications;Development;disability;disability risk;Disabling condition;Disease;efficacy testing;Elderly;Enrollment;Exposure to;Feeling;Funding;Gait speed;Geriatrics;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hydrocortisone;Hypothalamic structure;Individual;Inflammatory;innovation;Interleukin-6;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Link;Low Back Pain;Measurement;Measures;Mediating;Mentorship;mindfulness;Monitor;mortality;Movement;Neurodegenerative Disorders;novel;older adult;Outcome;overtreatment;Pain;pain catastrophizing;Pain Research;Participant;Patient Outcomes Assessments;Patient Self-Report;Peripheral;Physical activity;Physical Function;physical therapist;Physiological;Pilot Projects;Pituitary Gland;poor health outcome;Population;Positioning Attribute;Principal Component Analysis;Procedures;programs;Prospective Studies;psychologic;psychological distress;Questionnaires;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;response;Rotation;Safety;Sampling;Science;Self Efficacy;Serum;Spinal;stem;Stress;stress reactivity;Stress Tests;Stressful Event;stressor;Structure;Testing;therapeutic biomarker;therapy development;Thinking;Time;Trier Social Stress Test;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Stress Reactivity and Low Back Pain in Older Adults: Influences on Disability (ReLOAD)


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Parkinsonism is the second most common movement disorder in the U.S, affecting over 900,000 Americans (projected to reach greater than 1.2 million by 2030) and dystonia (involving the development of abnormal posturing and uncomfortable twisting) is the third most common, afflicting more than 250,000 Americans: both disorders are a considerable source of morbidity and disability. X-linked dystonia parkinsonism (XDP), a rare neurogenetic movement disorder has a combination of both generalized dystonia and parkinsonism, with a wide phenotypic spectrum and may represent an independent genetic risk factor for the development of parkinsonism in female heterozygous carriers, such that studying XDP, while comparing to both disorders in isolation (DYT1, another hereditary dystonia, and Parkinson's disease, the archetypal parkinsonism) will inform both of these phenotypes, as well as the understanding and assessment of mixed movement disorders. This project will provide important contributions to the literature by providing: 1) new ways to quantify the neurological examination, which could identify rater-independent relevant clinical trial endpoints; and 2) potential motor and proposed blood markers, which, using machine learning, may be more accurate in combination, as a method to detect early disease, track progression and predict disease course, which will benefit not only XDP but other conditions with both of these motor phenotypes and neurogenetic disorders.

PI_NAMEs: STEPHEN, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;American;Award;Biochemical;Biochemical Markers;biochemical model;Bioinformatics;Biological Markers;Biology;biotypes;Blood;career development;Clinical;Clinical assessments;clinical trial readiness;Clinical Trials;clinically relevant;cohort;Complex;Data;Detection;Development;Development Plans;differential expression;disability;Disease;disease phenotype;Disease Progression;Dystonia;early detection biomarkers;Early Diagnosis;Early identification;Evaluation;Female;Filipino;follow-up;Foundations;Functional disorder;Genetic;genetic risk factor;Goals;Hereditary Dystonia;Heterozygote;Inherited;innovative technologies;insight;Introns;Knowledge;Learning;Light;Literature;Machine Learning;machine learning algorithm;Measures;Mentorship;Methods;Minisatellite Repeats;Modeling;molecular marker;Monitor;Morbidity - disease rate;Motion;motion sensor;Motor;motor behavior;movement analysis;Movement Disorders;National Institute of Neurological Disorders and Stroke;Natural History;Nerve Degeneration;Nervous System Disorder;neurofilament;neurogenetics;Neurologic Examination;Parkinson Disease;Parkinsonian Disorders;participant enrollment;Patients;Performance;Phenotype;Philippines;Population;Positioning Attribute;Posture;predictive modeling;Prevalence;Rare Diseases;Research;Research Personnel;Risk;RNA Splicing;Science;sensor;Severities;Severity of illness;skill acquisition;skills;Source;Standardization;Symptoms;TAF1 gene;Techniques;Technology;tool;Training;Transcript;X Chromosome;X Inactivation;X-linked dystonia parkinsonism

PROJECT_TITLE: Clinical trial readiness in X-linked dystonia parkinsonism: assessment of sensor-based and blood biomarkers for early detection and monitoring disease progression

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: Project Narrative IgG4-related disease is an autoimmune fibrotic disorder that affects multiple organs and causes tumor-like masses, often misdiagnosed as metastatic cancer. Thus far, we have determined which types of immune cells are likely drivers of the disease, but the proteins driving this response and whether they are self or foreign, remain largely unknown. The knowledge gained from this research is hoped to lead to a more in-depth ability to learn how immune cells interact with each other in causing fibrosis.

PI_NAMEs: PERUGINO, CORY  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: adaptive immune response;Affect;Alleles;Antigen Receptors;Antigen Targeting;Antigens;Apoptosis;Arthritis;Autoantibodies;Autoantigens;Autoimmune;Automobile Driving;B cell therapy;B-Cell Activation;B-Lymphocytes;biobank;Bioinformatics;Biological Assay;Biometry;Blood;career;CD4 Positive T Lymphocytes;Cell Communication;Cells;Center for Translational Science Activities;Clinical;Clinical Immunology;clinical investigation;clinical phenotype;clinical remission;Clinical Sciences;Clonal Expansion;Clone Cells;cohort;Collaborations;cytotoxic;Deposition;Development;Disease;Disseminated Malignant Neoplasm;Environment;Epitopes;Extracellular Matrix Proteins;Faculty;Fibrosis;forging;Fostering;Foundations;Funding;Future;Galectin 3;General Hospitals;Genes;Goals;HLA-DR Antigens;Human;Hypersensitivity;IgG4-related disease;Immune;immune cell infiltrate;Immune response;Immunologic Receptors;Immunologics;Individual;individual patient;Infiltration;Investigation;Journals;Knowledge;Learning;Learning Skill;Libraries;Light;Link;Mass Spectrum Analysis;Massachusetts;Mediating;member;Mentors;Mentorship;Mesenchymal;Molecular;Molecular Biology;Monoclonal Antibodies;novel;Organ;Paper;Parents;Pathogenesis;Pathogenicity;patient subsets;Patients;Peptide/MHC Complex;Peptides;Phenotype;Positioning Attribute;programs;Proteins;Publishing;Recombinants;Reporting;repository;Research;Research Personnel;response;Rheumatology;Sampling;Scientist;screening;Series;Severity of illness;single cell sequencing;single-cell RNA sequencing;skills;Specificity;Statistical Data Interpretation;Systemic Scleroderma;T cell receptor repertoire sequencing;T cell response;T-cell receptor repertoire;T-Lymphocyte;Tissues;Training;Training Activity;Transforming Growth Factor beta;Translational Research;tumor;United States;United States National Institutes of Health;Universities;Validation;Work;Yeasts

PROJECT_TITLE: Defining the antigenic determinants of the adaptive immune response in IgG4-related disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases;Sickle Cell Disease

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative Greater availability of ancestral Africans’ genomes will improve our understanding of genomic variations both for complex disease conditions and monogenic diseases; improve disease-gene pairs’ curation; and avoid misclassifications of benign variants as disease-causing. However, there are concerns that the scientific imperative associated to increasing the proportion of African genomic variations in public databases will not necessarily translate into enhancing genetic medicine implementation in Africa and that the use of big data for health and innovation, while promising, raises ethical, legal and social issues (ELSI) around, respecting the views of individual data providers, the control of health information, inadvertent uses of data; ownership of intellectual property and patents; the potential of a big data divide, possibilities of various stakeholders to feel exploited. With a focus on big data in genomics medicine, Public Understanding of Big data in Genomics Medicine in Africa (PUBGEM-Africa) aims to use empirical methods to address some of these pertinent ELSI issues particularly as it relates to models of public engagement in big data use for healthcare and innovation; identifying the equity-oriented roles and responsibilities of stakeholders involved in big data use for genomics person; understanding public attitude to and perceptions towards big data in genomics medicine and the governance of big data; the development of equity-oriented governance frameworks for big data use in genomics medicine; and the setting-up of an an ELSI core that will host an ELSI help desk for data science in health in Africa and provide small grants and mentorship support to emerging data science bioethics scholars in Africa.

PI_NAMEs: MUNUNG, NCHANGWI SYNTIA;WONKAM, AMBROISE  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Adult;Africa;African;African ancestry;Attitude;Award;Benign;Big Data;Bioethics;Biotechnology;Cameroon;Cardiomyopathies;clinical care;Clinical Data;Code;Collaborations;commercialization;Complex;Computational Science;Consent;Country;Data;Data Coordinating Center;data privacy;Data Protection;Data Science;Data Scientist;design;Development;Disease;Ensure;Environment;Equity;Ethical Issues;ethical, legal, and social implication;Ethics;exome sequencing;experience;Family;Feedback;Foundations;Fragile X Syndrome;Funding;Genes;Genetic;Genetic Diseases;Genetic Enhancement;Genetic Medicine;genetic variant;Genetic Variation;Genome;genome wide association study;genomic data;Genomic medicine;genomic variation;Genomics;Genotype;Ghana;Grant;Guidelines;Hand;Health;health data;Health Sciences;Healthcare;hearing impairment;hereditary hearing loss;improved;Individual;Informed Consent;innovation;Institution;Intellectual Property;interest;International;Knowledge;Learning;Legal patent;Link;Literature;Medical;Medical Ethics;Mendelian disorder;Mentorship;Methods;Modeling;Non-Insulin-Dependent Diabetes Mellitus;novel;Ownership;Participant;Patients;Perception;Persons;Phenotype;Population;population health;Positioning Attribute;Privacy;Process;programs;Provider;public database;Public Health Informatics;Readiness;Research;Research Ethics;Research Ethics Committees;Research Project Grants;Risk;Role;Sample Size;Schizophrenia;Sickle Cell Anemia;sickling;Site;South Africa;System;Training;trait;Translating;Universities;Variant;Vulnerable Populations


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: BALLARD, BILLY RAY (contact)

PROJECT_TERMS: Advocacy;African American;African American population;Anatomy;animal tissue;anti-cancer research;Antigens;Awareness;Basic Science;Bioinformatics Shared Resource;Biological Markers;Biometry;Biopsy Specimen;Blood;Cancer Center;cancer health disparity;Cells;clinical diagnostics;Clinical Trials;Collaborations;Collection;Communities;Consultations;design;Development;DNA;Doctor of Philosophy;Drug or chemical Tissue Distribution;Education;Equity;Fee-for-Service Plans;Fluorescence;Formalin;Foundations;Future;General Hospitals;Genomics;Goals;Histologic;Histology;Histopathology;Human;human tissue;imaging capabilities;Immune;In Situ;Institution;liquid biopsy;Malignant Neoplasms;Medical Research;medical schools;Messenger RNA;microscopic imaging;Minority Groups;Molecular Biology;molecular diagnostics;Morphology;neoplastic;Normal tissue morphology;Operative Surgical Procedures;outreach;Paraffin Embedding;Pathology;Pilot Projects;Population;Population Research;Process;Proteomics;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Services;Slide;Stains;Techniques;Technology;Tennessee;Time;Tissue Banks;tissue processing;Tissue Sample;Tissues;Translational Research;Universities;Work

PROJECT_TITLE: Translational Pathology Core


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Telehealth;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Concussions are highly prevalent in the pediatric population, and are associated with significant morbidity. Currently, there are limited methods to predict early in the course of the injury which concussed children will develop persistent symptoms, and, for those determined to be high risk, multiple barriers exist in ac- cess to concussion specialists who can prescribe active therapies shown to improve recovery time. By in- corporating objective visio-vestibular deficits into risk models, and utilizing an innovative mobile health in- tervention to improve specialist access and care continuity, we can more successfully match novel inter- ventions to those most in need of their benefits, ultimately reducing recovery times and the related physi- cal, cognitive, and emotional morbidity for pediatric concussion patients.

PI_NAMEs: CORWIN, DANIEL  (contact)

PROJECT_TERMS: 18 year old;Accident and Emergency department;Acute;Adoption;Age;Applied Research;Area;Award;barrier to care;Biometry;Brain Concussion;career;career development;Caring;Child;Child health care;Childhood;Clinic;Clinical;clinical center;clinical epidemiology;Clinical Trials;Cognitive;comorbidity;Continuity of Patient Care;cost;Data;Dedications;design;Development;Diagnosis;disability;Discrimination;Early Intervention;Ecological momentary assessment;Ecosystem;Educational process of instructing;effectiveness evaluation;efficacy evaluation;efficacy outcomes;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency Medicine;Emotional;Enrollment;Environment;evidence base;experience;Family;Female;Functional disorder;Goals;health communication;health economics;Health system;Health Technology;high risk;Hour;improved;improved outcome;Incidence;Individual;Injury;innovation;Institution;Intervention;Judgment;male;Measures;medical specialties;Mentors;Methodology;Methods;mHealth;mhealth interventions;Modeling;Monitor;Morbidity - disease rate;Nature;novel;novel therapeutics;Observational Study;Outcome;patient oriented research;Patients;pediatric emergency;Pediatric Hospitals;Pennsylvania;Performance;persistent symptom;Persons;Philadelphia;Physicians;Physiological;Population;Positioning Attribute;Post-Concussion Syndrome;predictive modeling;prevent;Prevention;prospective;Provider;public health insurance;Recommendation;Recovery;reduce symptoms;Registries;Research;research and development;Resources;Rest;Risk;Risk Assessment;Risk Factors;risk stratification;ROC Curve;Science;Scientist;sex;skills;Specialist;Sports Medicine;standard of care;Symptom Burden;symptomatology;Symptoms;System;targeted delivery;telehealth;Time;tool;Training;Underrepresented Minority;Universities;usability;Vestibular dysfunction;vestibular system;women versus men;Work;Youth

PROJECT_TITLE: Risk Stratification Using Physiologic Markers and Mobile Health-Facilitated Specialist Management to Improve Outcomes in Pediatric Concussion Patients


PROJECT_TERMS: Address;Bioinformatics;Bioinformatics Shared Resource;Biometry;Biostatistics Core;Biostatistics Shared Resource;Cancer Center;cancer health disparity;Clinical;Clinical Trials;Collaborations;Computer software;Data Analyses;data cleaning;data quality;data visualization;database design;design;Development;Educational workshop;Ensure;Experimental Designs;experimental study;Funding;Human Resources;Individual;Information Storage;investigator training;Laboratory Study;Maintenance;Malignant Neoplasms;Manuscripts;medical schools;member;Methodology;Methods;multidimensional data;Participant;Pilot Projects;posters;power analysis;Publications;Quality Control;Questionnaire Designs;relational database;Reporting;Research;Research Design;Research Personnel;Retrieval;Role;Sample Size;Services;Statistical Data Interpretation;symposium;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Training;Universities;Work;Writing

PROJECT_TITLE: Biostatistics Core