NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE The autonomic innervation of the heart provides regulatory roles in heart function. Here, we propose to develop a 3D microphysiological co-culture platform to better understand fundamental aspects of sympatho-cardiac interaction and reciprocal regulation and growth of cardiac and autonomic cells. We will also establish a human model of cardiac muscle disease with sympathetic neurons, which will provide novel insights into understanding neuromodulation of cardiac pathogenesis.

PI_NAMEs: KIM, DEOK-HO  (contact);KWON, CHULAN

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Area;Arrhythmia;arrhythmogenic cardiomyopathy;Autonomic nervous system;Basic Science;Cardiac;cardiac muscle disease;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cell Nucleus;Cells;chronotropic;Coculture Techniques;cost effective;Data;Desmosomes;Development;developmental disease;Diabetes Mellitus;disease model;disease phenotype;Disease Progression;Disparity;drug testing;electric impedance;Electrodes;Electrophysiology (science);Etiology;Evaluation;Exhibits;Feedback;Gene Mutation;Genes;Genetic;Goals;Growth;Heart;Heart Diseases;heart function;heart innervation;Human;human disease;human embryonic stem cell;human induced pluripotent stem cells;human model;Impairment;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;Measures;Microelectrodes;Microfabrication;microphysiology system;Mitotic Cell Cycle;Modeling;Molecular;Monitor;multimodality;Muscle Cells;Myocardial Infarction;Natural regeneration;Neonatal;Nerve;nerve supply;Neurons;Neuropathy;neuroregulation;novel;novel therapeutics;optogenetics;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Performance;Phenotype;Physiological;Physiology;Population;pre-clinical;Process;Property;Regulation;Reporter;Research;Resolution;Rodent;Role;Specific qualifier value;spheroids;Structure;Structure of superior cervical ganglion;Sudden Death;Sympathectomy;synaptogenesis;System;targeted treatment;Techniques;Testing;Therapeutic;tissue culture;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Microphysiological Model of Human Cardiac Sympathetic Innervation

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We will investigate the contribution of structural racism to mortality among Black, Hispanic/Latino, Japanese American, and Native Hawaiian adults, leveraging the well-characterized and racial/ethnically and socioeconomically diverse Multiethnic Cohort Study in Southern California and Hawaii. New measures of structural racism including variables from housing, education, employment, criminal justice, political participation, and healthcare will be developed to reflect experiences of each racial/ethnic group.

PI_NAMEs: CHENG, IONA C;SHARIFF-MARCO, SALMA  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adult;Alaska Native;Alcohol consumption;Alcohols;Alzheimer's Disease;American;American Indians;Asian Americans;Attention;Black Populations;Black race;California;Cardiovascular Diseases;Cause of Death;Censuses;Cessation of life;Chronic;Cities;cohort;Cohort Studies;Communities;community advisory board;Community Surveys;comorbidity;Criminal Justice;Data;density;Development;Diabetes Mellitus;Diet;Discrimination;Disease;Education;Employment;Environment;Environmental Hazards;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Exposure to;follow-up;Geography;Hawaii;Hawaiian population;Health;Health behavior;health inequalities;Healthcare;Hispanic;Housing;improved;indexing;Individual;Inequity;Institution;Intervention;Investigation;Japanese American;Knowledge;Latino;Life;life span;Malignant Neoplasms;Measures;Mediating;Methods;mortality;mortality risk;multi-ethnic;multidisciplinary;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Participant;Physical activity;Policies;Policy Maker;Politics;Population;Population Study;Premature Mortality;Prospective Studies;Race;racial minority;racial minority population;racial population;Research;Research Personnel;residential segregation;Respiratory Disease;Scientist;segregation;sex;Smoking;Social support;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Source;Structural Racism;Subgroup;System;Tobacco;years of life lost

PROJECT_TITLE: Understanding the impact of structural racism on racial/ethnic inequities in mortality: The Multiethnic Cohort Study

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: SOUTH HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: MOUNT HOLYOKE COLLEGE

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because, while bacterial small RNAs (sRNAs) have been implicated in bacterial pathogenicity, much remains to be learned about their mechanisms of action and dependence on chaperone proteins. This work will uncover a wealth of fundamental biological knowledge about the mechanisms of bacterial RNA chaperone proteins, laying the foundation for them to serve as future targets for novel antibiotics. Thus, the project is relevant to the part of the NIH’s mission that pertains to reducing illness and to the specific interest of the Institute of General Medical Sciences in understanding noncoding RNA mechanisms of action and function.

PI_NAMEs: BERRY, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 5' Untranslated Regions;Address;Antibiotics;Bacteria;Bacterial Genes;Bacterial Infections;Bacterial RNA;Base Pairing;Binding;Biological;biological adaptation to stress;Biological Assay;Biology;Cells;Collaborations;college;Complement;Complex;Cytoplasm;Data;Dependence;Detection;Development;Ensure;Escherichia coli;Foundations;Future;Gene Expression;Gene Expression Regulation;Genetic;genetic approach;Genetic Techniques;Genetic Transcription;Goals;Health;Homologous Gene;Human;human pathogen;Hybrids;improved;In Vitro;Individual;innovation;interest;KH Domain;Knowledge;Laboratories;Learning;Ligands;Medical;Messenger RNA;Methodology;Mission;Molecular;Molecular Chaperones;molecular phenotype;mRNA Expression;Mutation;novel;Organism;pathogenic bacteria;Pathogenicity;Phylogenetic Analysis;Play;polypeptide;Positioning Attribute;protein complex;Proteins;Public Health;Publishing;Research;Research Personnel;reverse genetics;RNA;RNA Binding;RNA chemical synthesis;RNA Probes;RNA-Binding Proteins;RNA-Protein Interaction;Role;Salmonella;Science;Small RNA;Specificity;Structure;success;Surface;System;Techniques;Tertiary Protein Structure;Testing;therapeutic target;tool;undergraduate research experience;undergraduate student;United States National Institutes of Health;Untranslated RNA;Virulence;Work

PROJECT_TITLE: Genetic Identification of Bacterial RNA Chaperone Proteins and their Mechanisms of Action

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Nutrition;Physical Activity;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE A growing number of studies suggest that increasing dietary protein intake and lowering the dietary acid load of the diet improves markers of muscle health in older adults. This proposal describes a study designed to determine whether adding an alkaline salt, potassium bicarbonate, to reduce the dietary acid load of a high protein diet can further enhance the beneficial impact of a high protein diet alone on muscle performance and mass. Understanding whether high protein and alkali supplementation have an additive benefit to muscle in older adults is critically important in moving the field forward towards development of innovative therapeutic approaches to reduce the physical disability in our aging society.

PI_NAMEs: CEGLIA, LISA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acidosis;Acids;Adult;age related;age related decline;Aging;aging process;Alkalies;Amino Acids;Area;base;Bicarbonates;Body Weight decreased;Catabolism;Consumption;Data;Development;Diet;dietary;Dietary Intervention;Dietary Proteins;Dose;Double-Blind Method;Enrollment;epidemiology study;Equilibrium;Excretory function;Exercise;Extensor;feeding;Food;fruits and vegetables;functional decline;Health;human old age (65+);Impairment;improved;indexing;Individual;innovation;Intake;Intervention;Intervention Studies;Isotonic Exercise;Kidney;Knee;Lead;lean body mass;Leg;Link;Lower Extremity;Measures;men;metabolic abnormality assessment;Metabolic acidosis;Muscle;muscle form;Muscular Atrophy;Musculoskeletal;Nitrogen;older adult;older men;Outcome;Participant;Performance;Physical Function;Physical Performance;physically handicapped;Pilot Projects;Placebo Control;Placebos;Population;Postmenopause;potassium bicarbonate;primary outcome;protein intake;Protein-Restricted Diet;Proteins;Randomized;Recommended Daily Allowances;Renal function;Reporting;Research;Research Design;Roentgen Rays;secondary outcome;sedentary;Skeletal Muscle;skeletal muscle wasting;Societies;Sodium Chloride;Stimulus;Sulfur;Supplementation;Testing;Therapeutic;Thinness;Translating;urinary;Whey Protein;Woman

PROJECT_TITLE: Impact of protein and alkali supplementation on skeletal muscle in older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Physical Activity;Prevention;Women's Health Research

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

PI_NAMEs: HICKNER, ROBERT C (contact);ORMSBEE, MICHAEL

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Abdomen;Acute;Adipocytes;Adipose tissue;Adrenergic Agents;Affect;Age Years;Area;Behavior;beta-adrenergic receptor;blood glucose regulation;Body Composition;Body fat;Body Weight;Calories;Cardiometabolic Disease;Catecholamines;Chronic;Closure by clamp;comorbidity;Data;Disease;disorder risk;Effectiveness;endurance exercise;Energy Metabolism;Environmental Risk Factor;Equilibrium;evidence base;Exercise;exercise prescription;exercise training;experimental study;Fatty acid glycerol esters;flexibility;Future;Glucose;Glucose Clamp;glycemic control;Glycerol;Goals;Health;Heart Atrium;Hour;Hyperinsulinism;Impairment;improved;in vivo;Indirect Calorimetry;Individual;Insulin;Insulin Resistance;Investigation;Knowledge;Laboratories;Link;lipid biosynthesis;lipid metabolism;Lipolysis;male;Measurement;Measures;Mediating;men;Metabolic Diseases;Metabolic syndrome;Metabolism;Methodology;Microdialysis;mode of exercise;Monitor;Muscle;Non obese;Non-Insulin-Dependent Diabetes Mellitus;obese person;Obesity;oxidation;Palmitates;Participant;Pathway interactions;Perfusion;Persons;Phentolamine;Physical activity;Play;Postmenopause;Prediabetes syndrome;prevent;Propranolol;Proteins;Publishing;Regulation;Reporting;Resistance;resistance exercise;response;Rest;Risk Reduction;Role;saluretic;Skeletal Muscle;Somatotropin;stable isotope;Stimulus;subcutaneous;System;Testing;Thigh structure;Training;Training Programs;Walking;Water;Weight Gain;weight maintenance;Weight maintenance regimen;Woman

PROJECT_TITLE: Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Despite tremendous progress in our understanding of peroxisomal matrix and membrane protein import and the machinery involved in these aspects of peroxisome biogenesis, we know little about how this organelle is formed de novo. This proposal will define and characterize the genes/proteins involved in this process, study the functions of a subset of both new and known proteins in peroxisome biogenesis, and also define the mechanism of how mitochondrial metabolites and energy production influence peroxisome proliferation. Although our work uses yeast models, we expect the outcomes to be relevant to human peroxisome biogenesis disorders, because the processes we are investigating are conserved in evolution.

PI_NAMEs: AITCHISON, JOHN D.;SUBRAMANI, SURESH  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Alcohols;Aldehydes;Autophagocytosis;Award;Bile Acids;Biogenesis;Biological Process;Biology;Birth;Cells;Cellular biology;Cholesterol;Collaborations;Communication;Communities;Comprehension;Cues;debilitating symptom;Development;Diagnosis;Disease;Essential Genes;Eukaryota;Evolution;experimental study;fascinate;Funding;Future;Genes;Genetic Screening;Glean;Goals;Grant;Growth;high throughput screening;Homeostasis;Human;Hydrogen Peroxide;Immunity;innovation;insight;Investigation;Ions;Laboratories;Link;Lipids;long chain fatty acid;Membrane;Membrane Proteins;Metabolic Pathway;Mitochondria;Molecular Biology;mutant;Mutation;Nature;Nitrites;novel;Organelles;Outcome;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;Patients;peroxisome;peroxisome membrane;Peroxisome Proliferation;Plasmalogens;Positioning Attribute;Process;Production;Protein Import;Proteins;Quality Control;Recording of previous events;Research;response;Rewards;Role;Signal Transduction;Site;success;Superoxides;System;Technology;Time;United States National Institutes of Health;Vacuole;Vesicle;Viral;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Targeting of proteins into peroxisomes

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Treatment of pain remains a major unmet need. Opiates continue to be useful pharmacotherapy for treatment of moderate to chronic pain but suffer from severe side effects that has led to an epidemic in America. The development of safe, effective and well-tolerated pain medications without side effects based on delta opioid receptors will be a major advancement in the treatment of pain that would greatly enhance both quality and length of life of patients both in the US and worldwide.

PI_NAMEs: CHE, TAO ;KATRITCH, VSEVOLOD ;MAJUMDAR, SUSRUTA  (contact);MCLAUGHLIN, JAY P.

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Absence of pain sensation;abuse liability;addiction;addiction liability;Adenosine;Adrenergic Agents;Adverse effects;Agonist;allodynia;Amino Acids;Analgesics;analog;Animal Model;Animals;Arrestins;Back;Behavioral;beta-arrestin;Binding;Binding Proteins;Binding Sites;Biological Assay;Brain;Cell Line;Cessation of life;Charge;chronic constriction injury;chronic pain;chronic pain management;Clinical;Complex;computational chemistry;Cryoelectron Microscopy;Crystallography;cysteinyl-leukotriene;delta opioid receptor;Dependence;design;Development;disability;Dopamine;Drug Kinetics;efficacious treatment;Epidemic;experience;F2R gene;G-Protein-Coupled Receptors;Generations;Goals;GTP-Binding Proteins;health economics;Human;In Vitro;in vivo;Lead;Ligand Binding;Ligands;Longevity;mechanical allodynia;Mediating;Membrane;Membrane Proteins;Metabolic;Morphinans;motivated behavior;Motor Activity;Movement;mu opioid receptors;Mus;Mutation;next generation;novel;novel strategies;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;opioid overdose;opioid use disorder;Pain;Pain Disorder;Pain management;pain model;painful neuropathy;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Physiological Processes;Plasma;Play;Population;pre-clinical;prescription opioid;prescription opioid misuse;Property;protein activation;protein complex;receptor;Receptor Activation;Resolution;screening;Seizures;Series;side effect;Signal Pathway;Signal Transduction;Site;socioeconomics;Sodium;sodium ion;structural biology;Structure;Structure-Activity Relationship;Testing;therapeutically effective;Transfection;Ventilatory Depression;Water

PROJECT_TITLE: Targeting the allosteric sodium site with novel probes for delta opioid receptor

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Opioids;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The emergency department (ED) provides care for patients with alcohol use disorders (AUD) and a variety of problems including illness, injury, or alcohol-related complication, creating a unique environment to intervene, enhance motivation, and initiate treatment among treatment and non-treatment seeking patients. This project is designed to test two clinically relevant ED-initiated treatment models for patients with alcohol use disorders (AUD) with facilitated referal and direct linkage to ongoing treatment. Our two models include currently underutilized psychosocial and pharmacological interventions with referral for continuation AUD treatment with the goal of promoting ongoing treatment engagement and less heavy drinking days.

PI_NAMEs: HAWK, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Acute;addiction;Address;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol intervention;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;analytical method;arm;Assessment tool;Automobile Driving;Behavior Therapy;binge drinking;buprenorphine treatment;Caring;Categories;Cause of Death;Characteristics;Chronic Disease;Client satisfaction;Clinical;clinically relevant;college;Combination Drug Therapy;Complication;cost effective;craving;design;Documentation;drinking;Drug usage;effective therapy;Effectiveness;Electronics;Emergency Department patient;Emergency department visit;Emergency Department-based Intervention;Emergency Medicine;Enrollment;Environment;Ethnic Origin;Evaluation;experience;Family;follow up assessment;gabapentin;Gender;Goals;Guidelines;hazardous drinking;Health;Health Personnel;Healthcare Systems;Heart Diseases;Heavy Drinking;housing instability;improved outcome;Individual;Infection;Injury;Inpatients;Insurance;Intervention;Interview;Life;Malignant Neoplasms;Mediation;Medical;medical specialties;medication compliance;Modeling;Morbidity - disease rate;mortality;Motivation;Naltrexone;novel;open label;opioid use;opioid use disorder;Oral;Outcome;Outcome Measure;Outcome Study;Outpatients;Participant;participant enrollment;Patient Care;patient engagement;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;primary care setting;primary outcome;programs;Prospective Studies;Protocols documentation;psychosocial;Race;Randomized;randomized, clinical trials;Recommendation;Records;Reporting;Respondent;Sampling Studies;screening, brief intervention, referral, and treatment;Societies;sociodemographics;Socioeconomic Status;Stroke;Surveys;Testing;Tobacco;Tobacco use;Treatment outcome;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Emergency Department-Initiated Medications for Alcohol Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: This program will provide unique research training experiences in infectious, developmental, and degenerative nervous system diseases. By combining cross-disciplinary team-mentored training in the immune-brain axis, the next generation of neuroscientists can incorporate multidisciplinary approaches towards that enable breakthrough advances. This is done to develop state-of-the-art diagnostic and therapeutic disease interventions.

PI_NAMEs: GENDELMAN, HOWARD E;MONAGHAN, DANIEL T (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Neuroimmunology of Disease Training Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE While advances in developmental biology and genetics have significantly improved our understanding of the basic signals that direct development and repair of the lung, targeted treatments for lung diseases remain limited. How tightly our genetic material is packaged in a structure called chromatin is emerging as means by which basic signals are integrated during development to direct lung formation and repair. By understanding the mechanisms by which PRDM3/16 regulates chromatin accessibility during lung development and lung injury, we aim to provide a foundation for the development of targeted strategies to modulate the epigenome to treat lung diseases.

PI_NAMEs: WHITSETT, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Adult;airway epithelium;Alveolar;alveolar epithelium;alveolar homeostasis;alveolar lamellar body;Alveolus;Architecture;ATAC-seq;Binding;Biochemical;Biological Assay;Birth;Bronchopulmonary Dysplasia;Cell Differentiation process;Cell Lineage;Cell Maturation;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin;Chronic lung disease;Cleavage Under Targets and Release Using Nuclease;Co-Immunoprecipitations;cofactor;Complex;Complex Mixtures;Data;Development;Developmental Biology;developmental genetics;differentiation in vitro;Disease;embryonic stem cell;Endothelium;Enhancers;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;EVI1 gene;Family;fetal;Fetal Lung;Fingers;Foundations;Future;Gases;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Materials;Genetic Transcription;Genome;genomic locus;Genomics;Health;histone methyltransferase;Histones;Homeostasis;Impairment;improved;In Vitro;in vitro Assay;in vivo;Inflammation;Influenza A virus;Injury;injury and repair;Label;Laboratories;Life;Lipids;Liquid Chromatography;Luciferases;Lung;lung development;Lung Diseases;lung injury;lung maturation;lung repair;Mediating;member;Molecular;Morphogenesis;Mus;Natural regeneration;Neonatal Respiratory Distress;Organoids;Pathogenesis;Perinatal;Phospholipids;Physiological;postnatal;Pregnancy;Premature Infant;prenatal;Preparation;prevent;Production;progenitor;Proliferating;Proline-Rich Domain;Promoter Regions;protein expression;protein protein interaction;Proteins;Proteomics;Pulmonary alveolar structure;pulmonary function;Pulmonary Surfactants;recruit;Regulation;Regulatory Element;repaired;Reporter;respiratory distress syndrome;Respiratory Failure;Role;Signal Transduction;Site;Specific qualifier value;stem cells;Structure;Surface;Surface Tension;surfactant;surfactant deficiency;tandem mass spectrometry;Testing;Transcript;transcription factor;transcriptome sequencing;Transgenic Mice;Viral;Zinc Fingers

PROJECT_TITLE: Prdm3/16 Regulate Chromatin Accessibility to Determine Alveolar Maturation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Primary Health Care

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Dental fear negatively affects the health of over 53 million American adults. Standard dental treatment (anti-anxiety medication or anesthesia) is compassionate but maintains the cycle of fear and avoidance; psychological treatments are effective but are rarely available and not easily disseminated. We will test a highly disseminable stepped-care approach, comprising a low intensity level (app + worksheet to foster dentist-patient communication around fear) and higher intensity level (for those needing more intensive treatment — 1- or 2-hours of in-person fear treatment from a mental health professional performed in the dentist's office).

PI_NAMEs: HEYMAN, RICHARD ELIOT (contact);SLEP, AMY MICHELE SMITH;WOLFF, MARK STEVEN

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Adoption;Adult;Affect;American;Anesthesia procedures;Anti-Anxiety Agents;Anxiety;anxiety management;Area;Awareness;Behavioral;Behavioral Model;Belief;Caring;Cellular Phone;Clinic;Cognitive Therapy;Collaborations;collaborative care;Communication;Computers;cost;Dental;Dental Anxiety;Dental Care;Dental Clinics;Dental General Practice;Dental Offices;Dental Schools;Dental Staff;Dentists;Development;Dose;efficacy testing;Enrollment;evidence base;falls;Focus Groups;Fostering;Fright;Health;Health Personnel;Health Professional;Healthcare;Home;Hour;Individual;Intervention;intervention refinement;Learning;life span;Light;Literature;Manuals;medical specialties;Medicine;Mental Health;metropolitan;mobile application;Modeling;New York;Oral health;Outcome;Pain;Paper;Patients;Pennsylvania;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Philadelphia;pilot test;Preventive;Private Practice;Privatization;Procedures;Protocols documentation;psychoeducation;psychologic;Public Health;Quality of life;Randomized;Records;recruit;Reporting;Research;Sampling;Self Administration;Sequential Multiple Assignment Randomized Trial;Signal Transduction;smartphone application;social;Societies;standard care;Step Tests;Surgeon;Testing;therapy development;tool;Touch sensation;treatment services;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Visit;volunteer;willingness;Work;Writing

PROJECT_TITLE: A Stepped-Care Approach to Treating Dental Fear: A Sequential, Multiple Assignment, Randomized Trial For Cognitive-Behavioral Treatment via Mobile App and Evidence-Based Collaborative Care


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The majority of health care appointments in the United States end with at least one prescription being written for the patient, but doctors may not have the necessary tools to chose the best medication and dose for any given disease or condition. The overarching goal of this proposal is to develop improved strategies that better inform clinicians on how to prescribe therapy that maximizes efficacy and minimizes harm based on the unique characteristics (demographics, genes, environment, and lifestyle) of a given patient. To do this, we will study past electronic health records from hundreds of thousands of patients to observe how they responded to drug therapy and look for patterns that link unique characteristics to favorable outcomes after taking a given medication.

PI_NAMEs: ONI-ORISAN, AKINYEMI  (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Address;admixture mapping;Adverse drug event;African American population;All of Us Research Program;American;Appointment;biobank;Biological;Biology;Biomedical Research;Black race;cardiovascular disorder epidemiology;care outcomes;Characteristics;Clinical;Clinical Pharmacology;clinical practice;cohort;Communities;Country;Data;Data Set;demographics;Descriptor;Disease;Disease susceptibility;diverse data;Dose;drug efficacy;East Asian;efficacy outcomes;Electronic Health Record;Ensure;Environment;Epigenetic Process;Equity;ethnic difference;ethnic minority;Ethnic Origin;Ethnic Population;European;Exclusion;Failure;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;genetic variant;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Goals;Harm Reduction;Health;health care disparity;Healthcare;Heritability;improved;Individual;Infrastructure;insight;Institution;Knowledge;Label;Latino;Latino Population;Life Style;Link;medication compliance;medication safety;Mexican Americans;Minority Groups;Molecular Genetics;multidisciplinary;non-genetic;novel;Outcome;Participant;Patients;Pattern;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;pharmacologic;Pharmacotherapy;Phenotype;Population;Population Heterogeneity;predicting response;predictive modeling;prevent;Proxy;Puerto Rican;Quantitative Trait Loci;Race;racial difference;racial minority;racial population;Recommendation;Reporting;Research;Resources;response;safety outcomes;side effect;social determinants;social factors;social health determinants;sociodemographics;Source;South Asian;study population;Therapeutic;tool;Traction;transcriptome;Underrepresented Populations;United States;United States Food and Drug Administration;United States National Institutes of Health;Variant;whole genome;Work;Writing

PROJECT_TITLE: Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative: The feasibility and clinical benefit of using a patient’s genotype to guide antiplatelet therapy prescribing decisions has been recently demonstrated. However, a more precise understanding of who to genotype, what to include on a genetic testing panel, and how to change antiplatelet therapy based on genotype results and other patient-specific factors is essential in order to optimize the impact of genotype-guided antiplatelet therapy on patient outcomes. Completion of this research project will elucidate the key factors that influence outcomes with a genotype-guided precision medicine approach to antiplatelet therapy, and establish optimal strategies that improve outcomes with this approach in a diverse, real-world setting.

PI_NAMEs: CAVALLARI, LARISA HUMMA (contact);LEE, CRAIG R

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acute;acute coronary syndrome;Address;adherence rate;Adoption;African American;African American population;African ancestry;Alleles;Aspirin;Blood Platelets;cardiovascular risk factor;Chronic;Clinical;clinical care;clinical outcome assessment;clinical practice;Clinical Practice Guideline;clinically relevant;clopidogrel;comorbidity;cost;CYP2C19 gene;Cytochrome P450;Data;DNA;Effectiveness;Enzymes;European ancestry;Event;Genetic;Genetic Carriers;genetic panel test;genetic testing;genetic variant;Genotype;genotyped patients;Goals;Hemorrhage;high risk;improved outcome;inhibitor;interpatient variability;Investigation;loss of function;Metabolism;novel;Observational Study;Outcome;Participant;Pathway interactions;Patient risk;Patient Self-Report;patient subsets;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;personalized strategies;Pharmacodynamics;pharmacologic;platelet function;Population;Population Heterogeneity;precision medicine;preference;Prevalence;prevent;Prodrugs;Race;racial diversity;racial population;Randomized, Controlled Trials;receptor;Registries;Research Project Grants;response;Risk;Risk Factors;Risk Reduction;Safety;safety and feasibility;Sampling;standard of care;Testing

PROJECT_TITLE: Precision antiplatelet therapy after percutaneous coronary intervention

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The Neuroscience Multi-Omic Archive (NeMO Archive) is a data repository that is specifically focused on the storage and dissemination of omic data from the BRAIN Initiative and related brain research projects.

PI_NAMEs: MAHURKAR, ANUP ;WHITE, OWEN R (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: analysis pipeline;archive data;Archives;Atlases;Binding Sites;Brain;brain abnormalities;Brain Diseases;BRAIN initiative;brain research;cell type;Cells;Chromatin;cloud based;cloud platform;cloud storage;Collaborations;Collection;Communities;computational platform;Computer software;computerized data processing;Consultations;Custom;Cytosine;Data;data access;Data Analyses;data archive;Data Collection;Data Coordinating Center;data ecosystem;data ingestion;data management;data modeling;data portal;data quality;data repository;data resource;Data Set;Data Storage and Retrieval;Deposition;Development;Diagnostic;Documentation;Educational workshop;Electronics;Elements;Ensure;Evaluation;experience;experimental study;FAIR principles;Familiarity;Feedback;Future;Generations;Genetic Transcription;Genomic Segment;hackathon;histone modification;Human;Human BioMolecular Atlas Program;Human Resources;indexing;innovative neurotechnologies;Institution;Knowledge;Location;machine learning prediction algorithm;member;Metadata;Methods;Modeling;Modification;Multiomic Data;multiple data types;multiple omics;neural circuit;Neurosciences;Neurosciences Research;next generation;Online Systems;operation;outreach;Patients;Pattern;Persons;Phenotype;Policies;Principal Investigator;Process;Prognosis;public repository;Publications;Quality Control;R24;Registries;Regulatory Element;Research;Research Personnel;Research Project Grants;Resources;Services;single cell analysis;Site;System;Technology;Testing;Time;tool;Training;transcription factor;United States National Institutes of Health;virtual;Visualization;Visualization software;web portal;web site;webinar;Work;working group

PROJECT_TITLE: A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Narrative: Public Health Relevance Atrial fibrillation (AF) is one of the most common heart diseases in the US. It is currently treated with radiofrequency ablation (RFA), but the 1-year recurrence rate is high (30-50%). We aim to create a multi-modal feedback-based navigation system and MR-compatible robotic platform that enables precise, continuous, and durable ablation lesion creation during MR-guided RFA for improved AF treatment

PI_NAMEs: CHEN, YUE  (contact);KOLANDAIVELU, ARAVINDAN ;SCHMIDT, EHUD JERUHAM;TOKUDA, JUNICHI

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Address;Algorithms;Animals;Arrhythmia;Atrial Fibrillation;Cardiac;Cardiac ablation;Cardiomyopathies;Catheterization;Catheters;Chronic;Clinical;Computer software;effective therapy;Electrophysiology (science);Ensure;Environment;Family suidae;Feedback;force feedback;Heart;Heart Diseases;Heart failure;Hybrids;Iatrogenesis;Image;imaging modality;improved;improved outcome;Incidence;Injury;innovation;Left;Left atrial structure;Lesion;Life;Location;Magnetic Resonance Imaging;metallicity;Methods;Monitor;Motion;multimodality;Navigation System;novel;Operative Surgical Procedures;Outcome;Pathology;Patients;Perforation;Persons;Physicians;Positioning Attribute;pre-clinical;Prevalence;Procedures;public health relevance;Pulmonary veins;Radiofrequency Interstitial Ablation;Recurrence;Research;Resolution;Risk;Robot;robotic system;Robotics;sensory feedback;Site;Stroke;System;Systems Integration;Techniques;Technology;Time;Tissues;Treatment outcome;treatment planning;Validation;virtual;Visualization;Work

PROJECT_TITLE: Improved arrhythmia ablation via MR-guided robotic catheterization and multimodal clinician feedback

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The Boston University Clinical HIV/AIDS Research Training (BU-CHART) program prepares outstanding M.D and Ph.D. trainees for careers as scientific leaders in HIV/AIDS research, with a focus on research in disadvantaged and underserved populations.

PI_NAMEs: LINAS, BENJAMIN P. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TITLE: BU Clinical HIV/AIDS Research Training Program (BU-CHART

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The need for well-trained investigators in the field of cardiovascular medicine is the justification for this program's existence and continuation. There are too few rigorously-trained cardiovascular investigators to take advantage of today's enormous growth in genetics, imaging, and technological advances. Since this program was first funded in 1984, the University of Utah has successfully trained over 110 cardiovascular investigators and is well-equipped to continue this success.

PI_NAMEs: DRAKOS, STAVROS GEORGE (contact);SHAW, ROBIN M

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiovascular system;Research;Training

PROJECT_TITLE: Training in Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Early atrophic age-related macular degeneration (AMD) represents an important time window in the course of so far untreatable atrophic AMD, as patients typically experience only some degree of visual dysfunction, while being at significant risk for marked further loss of vision. To allow the precise evaluation of upcoming therapeutic interventions, a better understanding of the manifestation and variable disease progression is needed. This project aims to investigate refined tools to detect and monitor early atrophic AMD more accurately, including the impact on visual dysfunction and quality of life.

PI_NAMEs: FLECKENSTEIN, MONIKA ;SCHMITZ-VALCKENBERG, STEFFEN  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Address;age difference;Age related macular degeneration;analysis pipeline;Angiography;Area;Atrophic;automated segmentation;Belief;Biological Markers;Blindness;Cells;Cessation of life;Clinical;Clinical Research;Clinical Trials Design;clinically relevant;Color;Data;Data Set;deep learning;Deposition;Development;Disease;Disease Progression;Evaluation;experience;Eye;Fundus;fundus imaging;Future;genetic variant;geographic atrophy;high risk;Image;Image Analysis;imaging Segmentation;Individual;innovation;instrument;Intervention;Kinetics;Knowledge;Learning;Lesion;Location;longitudinal, prospective study;loss of function;luminance;Manuals;Measures;Modeling;Monitor;multimodality;new therapeutic target;Nonexudative age-related macular degeneration;novel;Optical Coherence Tomography;Outcome Measure;Patient Outcomes Assessments;patient prognosis;patient safety;Patients;Pattern;Perimetry;personalized medicine;Phenotype;precision medicine;Predictive Factor;Predisposition;prevent;primary outcome;Probability;Prognosis;prognostic;Prognostic Factor;prospective;Quality of life;Questionnaires;Reading;Resolution;retinal imaging;Risk;Risk Factors;risk variant;Risk-Benefit Assessment;Sample Size;Scotoma;Speed;Standardization;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Time;Tissues;tool;Training;transfer learning;Translations;trend;trial design;United States Food and Drug Administration;Vision;Visual Acuity;visual dysfunction;Visual Fields;Visual impairment

PROJECT_TITLE: Progression of Early Atrophic Lesions in Age-related Macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Data Science

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Biomedical research now requires the use of computational methods and systems models to (i) process the large data current technologies generate, (ii) integrate different data types into a cohesive picture of the biological processes that are studied, (iii) test hypotheses about how the biological processes function, and (iv) generate new, testable hypotheses that further our biological understanding. Scientists that can develop and use these computational methods and systems models require cross-disciplinary training in collaboration, scientific rigor, and quantitative methods. The Systems & Biomolecular Data Sciences training program brings together 12 degree-granting programs and 34 faculty mentors across the UVA Schools of Medicine, Engineering, Data Science, and Arts & Sciences to prepare this next generation of transdisciplinary biomedical scientists at the interface of quantitative biology, systems biology, machine learning, and informatics.

PI_NAMEs: JANES, KEVIN A;PAPIN, JASON  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Data Science;System;Training

PROJECT_TITLE: Interdisciplinary Training in Systems & Biomolecular Data Science

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: One hundred and fifty infant, under 2 years of age, with cerebral palsy, will be enrolled from 3 regions of the USA and randomized to receive intervention focused on motor-based problem solving or motor skills using normalized movement patterns. The interventions are dose (24 visits over 3 months), provider (physical therapists), and setting (home) matched to allow for direct comparison of the principles of the intervention. Outcomes including change in sitting ability, motor and cognitive development will be assessed at 3, 6, 9, and 12 months after enrollment.

PI_NAMEs: DUSING, STACEY CHAPMAN (contact);HARBOURNE, REGINA

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 2 year old;Address;Adherence;Affect;Age;Age Months;Basal Ganglia;Basic Science;Cellular Phone;Cerebral Palsy;Child;Childhood;Clinical;Clinical Trials;Cognitive;cognitive development;cognitive skill;Common Data Element;Communities;community intervention;comparative efficacy;comparison group;comparison intervention;Computer software;Control Groups;Data;Development;Diagnosis;Disabled Persons;Dose;Early Diagnosis;Early Intervention;Education;efficacy evaluation;Eligibility Determination;Enrollment;Environment;experience;Family;Family Characteristics;follow-up;Frequencies;gray matter;group intervention;Guidelines;high risk;Home;Impairment;improved;infancy;Infant;Injury;innovation;Intervention;Licensing;Manuals;Measures;Medical center;Methods;Monitor;Motor;motor learning;Motor Skills;Movement;Names;Neuronal Plasticity;Outcome;Outcome Measure;Parents;Pattern;Persons;physical therapist;Physical therapy;physically handicapped;Play;Play Therapy;Population;predicting response;prevent;Problem Solving;Protocols documentation;Provider;Randomized;Readiness;recruit;Rehabilitation therapy;Reporting;Research;response;Risk;Sample Size;Science;Secondary Prevention;Self Direction;service intervention;Site;skills;Strategic Planning;Stress;Subgroup;Therapeutic Intervention;Time;Toddler;Training;treatment as usual;Treatment Efficacy;United States;United States National Institutes of Health;Videotape;Visit;white matter

PROJECT_TITLE: Evaluation of the Efficacy of a Physical Therapy Intervention Targeting Sitting and Reaching for Young Children with Cerebral Palsy


NIH_SPENDING_CATS: Brain Disorders;Cancer;Genetics;Lung;Lymphatic Research;Orphan Drug;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Some pulmonary diseases occur disproportionately or almost exclusively in women, such as pulmonary LAM. Yet, the underlying mechanisms of specifically women’s susceptibility to LAM are still not been understood. Our current study of LAM lung cell composition and novel LAM-relevant genetic animal model lay the groundwork for developing a novel mechanistic understanding of LAM involving mTORC1-WNT signaling crosstalk and provide essential knowledge towards expanding effective therapy for this devastating disease.

PI_NAMEs: KRYMSKAYA, VERA P (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acceleration;Address;Age;age related;age related changes;AGTR2 gene;Alleles;Alveolar;alveolar epithelium;Animal Genetics;Animal Model;Asthma;AXIN2 gene;beta catenin;Cells;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical Trials;Code;Complex;Data;Disease;disease phenotype;druggable target;effective therapy;Epithelial Cells;Epithelium;Female;fitness;FRAP1 gene;gain of function;Gene Expression;Genes;Genetic;Growth;Hyperactivity;idiopathic pulmonary fibrosis;insight;Knowledge;Lesion;Ligands;Link;Lung;Lung Diseases;lung injury;Lung Lymphangioleiomyomatosis;Lymphangioleiomyomatosis;Mediating;Mesenchymal;Mesenchyme;Modeling;Molecular Target;mouse development;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Pneumothorax;Population;Predisposition;pulmonary arterial hypertension;pulmonary function;Pulmonary Pathology;Role;SDZ RAD;sex;side effect;Signal Pathway;single-cell RNA sequencing;Sirolimus;Smooth Muscle Myocytes;Structure;Testing;Therapeutic Intervention;therapeutic target;transcription factor;translational study;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;WNT Signaling Pathway;Woman

PROJECT_TITLE: mTORC1 and WNT in lung mesenchyme


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: NARRATIVE: Approximately one third of non-hospitalized COVID-19 patients report persistent symptoms after recovering from the acute stage of SARS-CoV-2 infection, with common complaints of “brain fog” and objective cognitive deficits. This project examines whether this post-acute COVID-19 syndrome involves dysfunctions in brain vasculature and the gut, as well as how such dysfunctions relate to chronic cognitive symptoms.

PI_NAMEs: VAKHTIN, ANDREI A (contact)

PROGRAM_OFFICER_NAME: SAWAKI-ADAMS, LUMY

PROJECT_TERMS: 2019-nCoV;ACE2;acronyms;Acute;acute COVID-19;Adult;Affect;Area;Attention;Autopsy;Binding;Biological Markers;Brain;brain fog;Breath Tests;Carbon Dioxide;Cerebral endothelium;cerebrovascular;cerebrovascular reactivity;Cerebrovascular system;Chronic;Clinical;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;Color;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic effects;COVID-19 patient;cytokine;cytokine release syndrome;Data;Disease;dysbiosis;Encephalitis;Endothelium;Endotoxins;Etiology;executive function;experience;Extramural Activities;fatty acid-binding proteins;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Gases;Gastroenterology;gastrointestinal system;Glial Fibrillary Acidic Protein;Grant;gut dysbiosis;gut health;gut microbiota;gut-brain axis;Health;Impaired cognition;Impairment;Individual;Infection;Infiltration;Inflammatory;innovation;inter-institutional;interest;Internal Medicine;Intervention;intestinal barrier;intestinal epithelium;Intestines;Lactulose;Left;Lipopolysaccharides;Long COVID;Measures;microbiota;Modeling;multidisciplinary;multimodal neuroimaging;multimodality;Nature;Neurobehavioral Manifestations;neuroimaging;neuroinflammation;neuropathology;Neuropsychology;neurotoxic;neurovascular;neurovascular unit;novel;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Peptidoglycan;Permeability;persistent symptom;Phase;Physiological;Plasma;precision medicine;processing speed;Proliferating;public health emergency;receptor;Recording of previous events;Recovery;recruit;Reporting;Research;Research Personnel;Respiration;Respiratory Signs and Symptoms;Role;SARS-CoV-2 infection;secondary analysis;Short-Term Memory;Smooth Muscle Myocytes;Solid;Statistical Data Interpretation;Structure;Symptoms;System;Text;Time;Toxin;Vascular Diseases;Viral;Virus;Visit;Work;zonulin

PROJECT_TITLE: Cognitive sequelae of cerebrovascular and gut dysfunction in post-acute COVID-19 syndrome.


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative These studies will provide novel insights into the regulatory mechanism of chitinase 1 (Chit1) in the pathogenesis of pulmonary fibrosis, a devastating lung disease with few therapeutic options. They will investigate mechanism and therapeutic effect of Kasugamycin, a small molecule with strong anti-chitinase and anti-fibrotic activities, using animal models of pulmonary fibrosis. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that helps to reduce the burdens of human disability.

PI_NAMEs: LEE, CHUN GEUN  (contact)

PROJECT_TERMS: Animal Model;Bacterial Infections;Binding;Binding Proteins;Biology;Chitin;Chitinase;Chronic Obstructive Pulmonary Disease;Circulation;disability;Disease;enzyme activity;Enzyme Tests;Evaluation;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;Gene Expression;Gene Family;Gene Proteins;Generations;Health;Human;Hydrolase;idiopathic pulmonary fibrosis;in vivo;indium-bleomycin;Individual;Inflammation;inhibitor;insight;Interstitial Lung Diseases;Intervention;Knowledge;Libraries;Life;Lung;Lung Diseases;Lysosomal Storage Diseases;Macrophage Activation;man;Mediating;Mediator;Mission;Mutant Strains Mice;Mycoses;Myofibroblast;Nature;novel;Nuclear;Ozone;Pathogenesis;Patients;Pharmaceutical Preparations;Phosphorylation;Play;Polysaccharides;Preventive;Prokaryotic Cells;Proliferating;Proteins;Pulmonary Fibrosis;Regulation;Reporting;Research;response;Role;Sarcoidosis;Scleroderma;screening;Signal Transduction;small molecule;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Therapeutic Uses;therapeutically effective;Time;Tissues;trafficking;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;Treatment Efficacy;United States National Institutes of Health

PROJECT_TITLE: Chitinase1 Regulation of Pulmonary Fibrosis and Therapeutic Targeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative! The proposed research aims to customize treatment and thereby improve clinical outcomes for African American (AA) patients with an aggressive type of breast cancer to which they are predisposed called triple-negative breast cancer (TNBC). This project will advance knowledge about how to customize treatment for AA TNBC patients by validating whether a novel protein biomarker, nuclear HSET, can better predict risk of poor clinical outcomes in AA than European American (EA) TNBC patients after accounting for factors that could confound analyses (like African genetic ancestry); how nuclear HSET may drive more aggressive tumor biology in TNBCs from AAs than EAs; and the potential clinical benefit of targeting nuclear HSET as an adjuvant to chemotherapy in AA and EA TNBCs.

PI_NAMEs: ANEJA, RITU  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Accounting;Address;Adjuvant;African;African American;African American population;African American Women;African ancestry;aggressive breast cancer;aggressive therapy;American;aurora kinase A;Automobile Driving;beta catenin;Binding;biobank;Biological;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Cancer Treatment;Cell Line;Cells;Centrosome;Chemoresistance;chemotherapy;chromatin modification;Chromosomal Instability;Clinical;Clinical Trials;cohort;Color;Combination Drug Therapy;Complex;Data;Death Rate;Development;Diagnosis;Disease;Disease Progression;Down-Regulation;druggable target;effective therapy;European;Excision;Experimental Designs;follow-up;Genes;Genetic;Genome Stability;genome-wide;Genotype;Goals;Growth;Hospitals;Impairment;improved;improved outcome;indexing;Individual;individualized medicine;inhibitor;Institution;Interphase;Kinesin;Knock-out;Knowledge;Malignant Breast Neoplasm;Medical center;Methods;migration;Mitosis;Modality;Modeling;Molecular;Motor;Neoplasm Metastasis;Nigeria;novel;novel therapeutics;Nuclear;Oncogenic;Outcome;patient biomarkers;patient population;Patient Self-Report;Patients;personalized medicine;Population;pre-clinical;precision medicine;preclinical study;prognostic;Prognostic Marker;prognostic tool;prognostic value;Proliferating;protein biomarkers;Proteins;Qualifying;Race;racial difference;racial disparity;Research;Risk Factors;risk prediction;Role;Sampling;Side;Signal Transduction;specific biomarkers;Specimen;Stains;Stratification;success;Survival Analysis;System;Testing;Therapeutic;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Tumor Markers;tumor progression;Universities;Validation;WNT Signaling Pathway;Xenograft Model;Xenograft procedure

PROJECT_TITLE: HSET as a racial disparity biomarker for TNBC patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Having health workers assist HIV-infected persons with the recruitment and testing of their sexual contacts and biological children is an effective and efficient way of identifying persons in need of HIV treatment and prevention. However, in Malawi, a country with a generalized HIV epidemic, health workers lack the counseling and coordination skills to routinely assist their HIV-infected clients with these services. This study will determine how to help health workers in Malawi to provide these services through a set of digital capacity-building tools.

PI_NAMEs: ROSENBERG, NORA  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;Africa South of the Sahara;AIDS prevention;arm;Biological;budget impact;Caring;Characteristics;Child;Client;Clinical;Collaborations;condoms;Contact Tracing;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Country;Data;Decision Trees;Diagnosis;digital;disability-adjusted life years;E-learning;effectiveness outcome;Emergency Situation;Epidemic;epidemic response;evidence base;Feedback;field study;Goals;Guidelines;Health;Health care facility;health organization;HIV;HIV Seronegativity;HIV Seropositivity;human centered design;Human immunodeficiency virus test;Hybrids;implementation outcomes;implementation research;implementation science;implementation strategy;implementation trial;improved;incremental cost;indexing;innovation;Inservice Training;insight;Institution;Intervention;Knowledge;Lead;Learning;Link;low and middle-income countries;Malawi;markov model;Methods;Modality;Modeling;Outcome;Patient Recruitments;Patients;Persons;pilot test;Play;Policies;Population;Prevention;primary outcome;Principal Investigator;Problem Solving;Procedures;Process;process improvement;programs;prospective;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Design;Research Methodology;Role;secondary outcome;service uptake;Services;Sexual Partners;skills;social cognitive theory;Structure;Tablets;technology intervention;Testing;theories;Thinking;tool;Training;Viral;Work;World Health Organization

PROJECT_TITLE: Enhancing HIV assisted contact tracing in Malawi through blended learning: An Implementation Science Study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PUBLIC HEALTH NARRATIVE  Major life transitions for emerging adults (the developmental period from ages 18-25), including graduation from high school and from college, are associated with changes in risk for alcohol misuse (heavy alcohol consumption and negative alcohol-related consequences). These transitions correspond with changes in facets of the self-concept related to drinking alcohol (or drinking identity), which has emerged as a promising, novel cognitive risk factor for alcohol misuse. We propose to evaluate the malleability of drinking identity and its subsequent effect on alcohol misuse during the transition out of high school and out of college by adapting a theory-based, social/personality psychology intervention strategy to change self- concept.

PI_NAMEs: LINDGREN, KRISTEN P (contact);NEIGHBORS, CLAYTON

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adult;Affective;Age;Alcohol consumption;alcohol craving;alcohol cue;alcohol expectancy;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol risk;alcohol use disorder;Alcohols;Behavior;Binding;Cognitive;college;craving;cue reactivity;design;Development;Dose;drinking;emerging adult;emerging adulthood;Ethnic Origin;experience;experimental study;Family;Foundations;Fright;Future;Gender;Goals;graduate school;Growth;hazardous drinking;Health Care Costs;Heterogeneity;high school;High School Student;Home;in vivo;Individual;Informal Social Control;Intervention;Laboratories;Life;Link;Literature;modifiable risk;Motivation;motivational processes;novel;Parents;peer;Personality;Population;Predictive Factor;prevent;Prevention;programs;Psychology;Public Health;Race;Randomized;Recording of previous events;recruit;Research;response;Risk;Risk Factors;Self Concept;Self Efficacy;Site;social;social norm;Students;substance use;Testing;theories;Time;transition to adulthood;trend;university student;Validation;Writing

PROJECT_TITLE: Targeting Drinking Identity as a Mechanism for Preventing and Reducing Hazardous Drinking During Adolescent and Young Adult Developmental Transitions

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE HIV infection is often comorbid with opioid use disorder, with both conditions interacting in a reciprocal manner to exacerbate the other condition, yet underlying brain mechanisms remain poorly understood. Here, we will use single cell sequencing technologies to define transcriptional responses to HIV infection and/or volitional opioid consumption in addiction-and cognition-relevant brain circuits in a cell type-specific manner in mice of which will investigate the contributions of cell type-specific transcriptional responses to the deleterious effects of HIV infection on cognition and on the development of opioid addiction-related behavioral abnormalities. If successful, this program of research may yield significant new insights into disease-relevant interactions between HIV and opioid use disorder with unprecedented cellular resolution.

PI_NAMEs: KENNY, PAUL J. (contact);VOLSKY, DAVID J

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;Acceleration;addiction;AIDS dementia;antiretroviral therapy;Behavior;Behavioral;Bone Diseases;Brain;brain cell;Brain region;Candidate Disease Gene;cardiovascular disorder risk;CD4 Positive T Lymphocytes;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;cocaine exposure;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;comorbidity;Consequences of HIV;Consumption;CRISPR/Cas technology;Data;Data Set;Development;Diabetes Mellitus;Disease;DNA;drug of abuse;Drug Use Disorder;Emotions;experience;Gene Expression;Gene Expression Profile;General Population;Generations;Genes;Genetic Transcription;Goals;Hand;Helper-Inducer T-Lymphocyte;Heroin;heroin use;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immunocompetent;Immunohistochemistry;In Situ Hybridization;in vivo;Individual;inducible Cre;Infection;Inflammation;innovation;insight;Intravenous;Investigation;Kidney Diseases;Laboratories;latent infection;Liver diseases;Macrophage;Memory impairment;methamphetamine exposure;Microglia;Molecular;Morbidity - disease rate;Morphine;mortality;Motivation;Mus;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;Opiate Addiction;Opioid;opioid abuse;opioid exposure;opioid injection;opioid mortality;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Procedures;programs;Recording of previous events;Research;Resolution;response;Rewards;Risk;Risk Factors;Self Administration;Severities;single cell sequencing;Site;System;T-Lymphocyte;Technology;Testing;Transcription Process;transcriptome;Viral Proteins;Virus

PROJECT_TITLE: Single cell brain transcriptome changes during chronic HIV infection and opiate use in conventional mice


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Liver Disease;Prevention;Rehabilitation;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Rising rates of alcohol-related liver disease (ALD) and mortality from alcohol consumption in ALD patients make connecting these patients to alcohol treatment critically important. There is an urgent need for interventions to improve alcohol treatment engagement in patients with ALD. This sequential, multiple-assignment, randomized trial (SMART) will test the efficacy of an adaptive intervention for improving rates of alcohol treatment engagement among patients with ALD.

PI_NAMEs: MELLINGER, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: adaptive intervention;addiction;Address;Adult;Age;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol prevention;Alcoholic Liver Diseases;Alcohols;Area;arm;Behavior Therapy;Caring;Clinic;Clinical;clinically relevant;cohort;COVID-19 pandemic;Data;Diagnosis;disease diagnosis;drinking;Early identification;efficacy evaluation;efficacy testing;Enrollment;Environment;follow-up;group intervention;Health;Health Services Accessibility;Hepatology;Improve Access;improved;innovation;Intervention;Intervention Trial;Interview;Life;Liver;Liver diseases;Liver Dysfunction;liver function;Mediator;Medical center;Michigan;mortality;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;patient engagement;Patient Preferences;Patients;Perception;Pharmaceutical Preparations;pilot trial;prevent;primary outcome;Randomized;randomized, clinical trials;recruit;relapse risk;Research;responders and non-responders;response;secondary outcome;Self Efficacy;Sequential Multiple Assignment Randomized Trial;sex;Site;Social Workers;Surveys;telehealth;tertiary care;Testing;Time;treatment as usual;Treatment Efficacy;trial design;uptake;usual care arm;virtual coach;Work

PROJECT_TITLE: Adaptive Interventions to Improve Alcohol Treatment Engagement among Alcohol-related Liver Disease Patients

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Suicide is the 2nd leading cause of death for adolescents and the rate of suicidal behavior has been increasing rapidly in Black youth. This Center, ETUDES (Enhancing Treatment and Utilization for Depression and Emergent Suicidality) is focused on augmenting the capacity of pediatric primary care to identify, refer, and manage youth at risk for suicidal behavior, with a special emphasis on making sure that the tools we develop to identify, refer, and reduce suicidal risk are effective and acceptable to Black youth and their families. In this Center, we will test novel methods of using health care records and mobile sensing to detect suicidal risk in youth, test interventions to improve referral, treatment engagement, and safety planning in primary care for suicidal youth, and test novel interventions designed to target known risk factors for depression and suicidal behavior, namely poor sleep, low activity, and online victimization that also may contribute to racial disparities in suicide risk.

PI_NAMEs: BRENT, DAVID A. (contact)

PROGRAM_OFFICER_NAME: SHERRILL, JOEL T

PROJECT_TERMS: 19 year old;access disparities;Address;Adolescent;adolescent suicide;aged;Anhedonia;Attention;Black Populations;Black race;career;Caregivers;Caring;Cause of Death;child depression;Childhood;Clinical;Clinical Trials;cohort;Collaborations;Communities;Complement;Consultations;Data;depression prevention;Detection;Development;disparity reduction;Education;effectiveness testing;electronic health data;Electronic Health Record;Emergency Situation;Event;experience;Family;Feeling suicidal;Funding;health disparity;health equity;Health Services Accessibility;Healthcare;high risk;high-risk adolescents;implementation science;improved;Individual;integrated care;Intervention;Leadership;Literature;Longitudinal Studies;Machine Learning;machine learning algorithm;Mediator;Mental Depression;Mental Health;Mental Health Services;Mentorship;Methods;Mission;mobile sensing;Monitor;novel;Outcome;Pathway interactions;Patient Preferences;Patient Self-Report;Patients;pediatrician;Physicians;Play;poor sleep;Population Heterogeneity;prediction algorithm;Predictive Analytics;predictive modeling;prevent;Prevention;Primary Care;primary care provider;primary care setting;Probability;Public Health;Publications;racial disparity;Randomized, Controlled Trials;Recommendation;Records;recruit;reducing suicide;Research;Research Training;Resources;Risk;Risk Factors;risk prediction;Role;routine screening;Safety;Sampling;Scientist;screening;Services;Sleep Disorders;Source;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;symposium;Teenagers;Testing;therapy design;therapy development;tool;Training;treatment as usual;trial comparing;Victimization;Visit;Work;Youth

PROJECT_TITLE: The Center for Enhancing Treatment and Utilization for Depression and Emergent Suicidality (ETUDES) in Pediatric Primary Care


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Patient Safety;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Suicide;Suicide Prevention

PROJECT_TERMS: 19 year old;access disparities;Address;Adolescent;Advocate;aged;Attitude;Black race;career;career development;Caregivers;Cause of Death;child depression;Childhood;Clinical;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Communication;Conduct Clinical Trials;Consultations;Data;design;Development;Development Plans;Disparity;Education;Ensure;Evaluation;Faculty;faculty mentor;Family;Funding;Goals;human centered design;human subject protection;implementation science;improved;innovation;Institutional Review Boards;Intervention;Intervention Studies;Knowledge;Leadership;Longitudinal Studies;Machine Learning;member;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Minority Groups;Mission;multidisciplinary;Natural Language Processing;next generation;Outcome;Patients;pediatrician;Pilot Projects;Policies;Policy Maker;Positioning Attribute;Primary Care;primary care clinician;primary care setting;Procedures;programs;Protocols documentation;Provider;Public Health;Publications;racial disparity;Research;Research Personnel;Resource Allocation;Resources;Rest;routine screening;Scientist;senior faculty;Site;skills;Standardization;Structure;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Testing;therapy development;tool;Training;Training Programs;Training Support;Underrepresented Minority;web site;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Data Science;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Primary Health Care;Suicide

PI_NAMEs: ROLLMAN, BRUCE LAWRENCE (contact)

PROJECT_TERMS: Adult;Advanced Development;analytical method;Area;Autopsy;Award;Black race;career;Caregivers;Cellular Phone;Childhood;Clinical;Collaborations;comorbidity;Consent;cultural competence;Data;data centers;data management;Data Management Resources;data sharing;Development;Electronic Health Record;Eligibility Determination;Emerging Technologies;Ensure;Evaluation;experience;Faculty;follow up assessment;Future;Goals;health equity;health equity promotion;Health Insurance Portability and Accountability Act;Health Services Research;Healthcare;high-risk adolescents;human centered design;implementation science;improved;Infrastructure;innovation;integrated care;Intervention;Knowledge;Machine Learning;machine learning algorithm;Medical center;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;mobile sensing;Natural Language Processing;Online Systems;patient engagement;Patients;Predictive Analytics;Prevention Research;Primary Care;primary care practice;primary care setting;programs;Provider;psychologic;Qualitative Methods;Qualitative Research;recruit;Reporting;Research;Research Methodology;Research Personnel;Resource Sharing;Resources;Risk;Risk Assessment;Safety;Scientist;screening;service engagement;Site;Software Design;Standardization;Structure;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Teenagers;Testing;Text;therapy development;Training;Universities;Update;uptake;Work;Youth

PROJECT_TITLE: Methods Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Patient Safety;Pediatric;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PI_NAMEs: MELHEM, NADINE M. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Affect;aged;Algorithms;analytical method;Anhedonia;automated text message;Belief;Black race;Caregivers;Caring;Cellular Phone;Childhood;Clinic;Clinical;cohort;community violence;comorbidity;Data;data fusion;Depression screen;Discrimination;Distress;Ecological momentary assessment;effectiveness testing;effectiveness/implementation hybrid;Electronic Health Record;Emergency Situation;Ensure;Event;Feedback;Feeling suicidal;Focus Groups;Funding;future implementation;Goals;Grant;health determinants;health disparity;health equity;health equity promotion;high risk;ideation;implementation efforts;implementation facilitators;implementation science;improved;integrated care;Intervention;Interview;Knowledge;Longitudinal Studies;Maps;Measures;Mediating;Mediator;Medical center;meetings;Mental Depression;Methods;mobile sensing;Monitor;Moods;Patient Self-Report;Patients;Pediatric Hospitals;pediatrician;Performance;Philadelphia;Physical activity;prediction algorithm;Predictive Analytics;preference;Prevention;Primary Care;primary care provider;primary care setting;primary outcome;protective factors;Provider;psychosocial;Randomized;randomized, clinical trials;Readiness;Recommendation;Recording of previous events;recruit;reducing suicide;response;Risk;Risk Assessment;Risk Factors;risk stratification;routine screening;Safety;Sampling;screening;service delivery;Services;Sleep Disorders;sleep pattern;social engagement;Stress;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;suicide attempter;Suicide prevention;suicide rate;Teenagers;Testing;text messaging intervention;Time;tool;treatment as usual;treatment comparison;treatment response;Universities;Work;Youth

PROJECT_TITLE: Prevention and Assessment of Risk in Teens (PART) Longitudinal Study


ORG_CITY: LITTLE ROCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE  Defined regions of the United States that have historically received lower levels of NIH funding face specific challenges for accessing key research resources to facilitate biomedical research within the mission of the National Institute of General Medical Sciences (NIGMS). To alleviate one such challenge in these regions, we will provide access to a national quantitative proteomics resource through the IDeA National Resource for Quantitative Proteomics. We will provide investigators in these regions of the United States access to user- friendly services for state-of-the-art, quantitative proteomics that will guide the user from service request to sample analysis to delivery of publication ready data.

PI_NAMEs: KINTER, MICHAEL T;TACKETT, ALAN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Administrative Supplement;Arkansas;Award;base;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biomedical Research;Charge;Computer software;Computers and Advanced Instrumentation;Core Facility;cost;Country;Data;Data Analyses;Development;Disease;Education;Education and Outreach;Educational workshop;Experimental Designs;Face;Faculty;Fees;fundamental research;Funding;Generations;Goals;Grant;human disease;Human Resources;Infrastructure;Institution;Institutional support resources;instrument;instrumentation;interest;Malignant Neoplasms;mass spectrometer;Mission;model organism;Modeling;National Institute of General Medical Sciences;Oklahoma;online resource;operation;outreach;Peer Review;Pilot Projects;Positioning Attribute;Principal Investigator;programs;Proteomics;Protocols documentation;Publications;Puerto Rico;Research;Research Personnel;Research Support;Resources;response;Sampling;service providers;Services;skills;Students;symposium;Training;Translational Research;United States;United States National Institutes of Health;user-friendly;voucher


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention

PI_NAMEs: GOLDSTEIN, TINA R (contact)

PROJECT_TERMS: actigraphy;Address;Adolescent;Adult;Age;aged;American;Attitude;Behavior;Belief;Black race;brief intervention;Caregivers;Categories;Cause of Death;Cellular Phone;child depression;Childhood;circadian;clinically significant;cohort;Complex;Consensus;Consolidated Framework for Implementation Research;Data;Diagnostic;diaries;Disparity;effective intervention;Enrollment;Equity;evidence base;experience;Feedback;Feeling suicidal;Focus Groups;Future;health equity;human centered design;Hypersomnias;implementation framework;implementation intervention;implementation science;improved;Intervention;Interview;Link;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Outcome;Participant;pediatrician;peer;poor sleep;Population;prevent;Prevention;preventive intervention;Primary Care;Provider;Qualitative Methods;racial discrimination;Racial Equity;Randomized;randomized trial;reducing suicide;Reporting;Research;Risk;Risk Assessment;Risk Behaviors;secondary outcome;Severities;Sleep;sleep difficulty;Sleep disturbances;sleep quality;Sleeplessness;sobriety;Source;statistics;Stigmatization;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Teenagers;Testing;usability;user-friendly;Wrist;Youth

PROJECT_TITLE: Brief Interventions for Teen Sleep (BITS)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Many genetic loci associated with phenotypic traits do not code for proteins but reside in noncoding regions by dysregulating gene expression. The dynamic nature of gene expression in specific cells and at particular developmental stages has prevented us from understanding noncoding mutations in human diseases and evolution. The goal of the proposed project is to introduce single-cell analysis in our human genome research: by leveraging a deep learning framework to integrate single-cell epigenomes and large-scale patient genomes, we will be able to determine the molecular context where noncoding mutations exert their pathogenic effects, and this new framework is expected to foster the development of therapeutic strategies targeting the most vulnerable cell types in human diseases. 1

PI_NAMEs: LI, JINGJING  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;Alleles;Architecture;Automobile Driving;Brain;Categories;cell type;Cells;Characteristics;Data;deep learning;deep learning model;Development;Disease;Effectiveness;Elements;epigenome;epigenomics;Evolution;Fostering;Future;Gene Expression;Gene Expression Regulation;Genome;genome analysis;genome browser;genome-wide;genomic locus;Germ-Line Mutation;Goals;Human;human disease;Human Genome;innovation;Knowledge;Laboratories;Literature;machine learning framework;machine learning model;Malignant neoplasm of prostate;Maps;Modernization;Molecular;Mutation;Nature;Pan Genus;Pathogenicity;Patients;Phenotype;Population;Premature Birth;Prevalence;prevent;programs;Prostatic Neoplasms;Proteins;Research;Resolution;Series;single cell analysis;Somatic Mutation;success;therapeutic development;tool;trait;Untranslated RNA;Variant;Visualization;Work

PROJECT_TITLE: Single-Cell Analysis of the Noncoding Genome in Human Diseases and Evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Organ Transplantation;Rare Diseases;Transplantation

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Hepatocellular carcinoma is on pace to become the leading global indication for liver transplantation, and rejection continues to be an important cause of graft loss and failure post-transplant. The diagnosis of rejection is not correlative to changes in liver blood tests and thus requires an invasive biopsy, and very little is known about which immune cells mediate this disease process. This application seeks to overcome this barrier by developing new mass cytometry-based methods to measure liver transplant rejection severity and progression, and these methods may become valuable tools for future clinical trials of immunosuppression minimization or withdrawal.

PI_NAMEs: EMAMAULLEE, JULIET  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acute;Address;Advisory Committees;Aftercare;allograft rejection;Allografting;Antibodies;Autoimmune Hepatitis;Award;Bioinformatics;Biological Assay;Biological Markers;Biopsy;Blood;Blood specimen;Blood Tests;California;career development;Career Mobility;Cells;Chronic;Clinical;clinical care;Clinical Trials;clinically relevant;complex data;Core Biopsy;Cytometry;Data;Data Analyses;Development;Development Plans;Diagnosis;Disease;Enrollment;Ensure;ethnic minority;experimental study;Failure;Funding;Future;Goals;Graft Rejection;Grant;hands-on learning;Hepatoblastoma;Histologic;Hospitals;Human;human subject;Image;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;Immunologic Markers;Immunologic Techniques;Immunologics;Immunology;Immunosuppression;improved;individual patient;Infiltration;intrahepatic;isoimmunity;Kidney Transplantation;Knowledge;Laboratories;Learning;Liver;liver biopsy;Liver Function Tests;liver injury;Liver parenchyma;liver transplantation;Los Angeles;Lymphocyte;Lymphocyte Subset;Maps;Measures;Mediating;Mentors;Mentorship;Methods;Mission;Molecular Analysis;novel;novel diagnostics;novel marker;Operative Surgical Procedures;Organ Transplantation;Outcome;Pathway interactions;Patients;Pattern;Pediatric Hospitals;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Population;post-transplant;Primary carcinoma of the liver cells;primary sclerosing cholangitis;Process;professor;prospective;Protocols documentation;Public Health;Research;Research Design;Research Personnel;Research Project Grants;Resources;Schedule;Severities;skills;Solid;spatial relationship;Specimen;Stains;Strategic Planning;Techniques;Therapeutic;Time;Tissue Sample;Tissue Transplantation;Tissues;tool;Training;Translational Research;Transplant Recipients;Transplant Surgeon;Transplantation Immunology;United States National Institutes of Health;Universities;Withdrawal;Woman;Work

PROJECT_TITLE: Immunologic Biomarkers of Rejection in Clinical Liver Transplantation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention

PI_NAMEs: JONASSAINT, CHARLES RICHARD (contact)

PROJECT_TERMS: Accelerometer;Address;Administrator;Adolescence;Adolescent;Affect;African American;Age;aged;Anhedonia;Attitude;Behavior;Behavioral;Behavioral trial;Belief;Black race;Caregivers;Cellular Phone;Childhood;clinically significant;Cognitive Therapy;cohort;Communities;Consolidated Framework for Implementation Research;culturally appropriate intervention;Data;depressive symptoms;digital;digital delivery;digital mental health;digital platform;Ecological momentary assessment;Effectiveness;Eligibility Determination;Enrollment;Equity;experience;Feedback;Feeling suicidal;Focus Groups;Goals;Health;Health Disparities Research;health equity;high risk;Home;human centered design;implementation framework;implementation science;implementation strategy;improved;Individual;interest;Intervention;Interview;Investigation;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;mobile computing;mobile sensing;Modeling;Monitor;Multimedia;Outcome;pleasure;Population Heterogeneity;Positive Reinforcements;prevent;Primary Care;Provider;Psychotherapy;Qualitative Methods;racial disparity;racial diversity;Racial Equity;racial population;Randomized;randomized trial;recruit;Research Personnel;Rewards;Risk;Risk Behaviors;Risk Factors;Sampling;secondary outcome;Severities;smartphone application;Social isolation;study population;suicidal;suicidal adolescent;suicidal behavior;suicidal individual;suicidal risk;Suicide attempt;Suicide prevention;suicide rate;Symptoms;System;Technology;Technology Assessment;Testing;Therapeutic;Time;tool;treatment program;trial comparing;uptake;usability;Youth

PROJECT_TITLE: Geospatial and Ecological momentary assessment Technology and Activity Engagement for at-risk youth


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Telehealth;Violence Research;Youth Violence

PI_NAMEs: ESCOBAR-VIERA, CÉSAR GABRIEL (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent suicide;aged;Artificial Intelligence;Attention;automated intervention;Behavior;Behavior assessment;behavioral health;Black race;Caregivers;Caring;chatbot;child and adolescent victimization;child depression;Childhood;Computer software;Consolidated Framework for Implementation Research;coping;Data;depressive symptoms;Development;digital;Discrimination;Distress;distress tolerance;Early Diagnosis;Early Intervention;Education;Effectiveness;Eligibility Determination;Enrollment;Equity;Exclusion;Exhibits;experience;Exposure to;Feedback;Feeling suicidal;Frequencies;Friends;gender minority status;gender minority youth;Health;health disparity;Health Services;human centered design;Image;implementation facilitators;implementation framework;improved;Intervention;Interview;iterative design;Link;Loneliness;Measures;media use;medical specialties;Mental Depression;Mental Health;Methods;minority children;Minority Groups;mobile sensing;novel;online intervention;Online Systems;Outcome;Participant;patient engagement;Patients;peer influence;Perception;preference;prevent;Primary Care;primary care provider;programs;Provider;psychoeducation;psychoeducational intervention;Race;Racial Equity;Randomized;randomized trial;Research;Resources;response;Risk;Risk Behaviors;Rural;secondary outcome;Self Efficacy;Self Management;Services;Severities;Sexual and Gender Minorities;sexual minority youth;social;social media;Source;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide prevention;technology intervention;Testing;Text;therapy development;trial comparing;usability;Victimization;Voice;Work;Writing;Youth

PROJECT_TITLE: Social Media Intervention for OnLinE Victimized Youth


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PHR: Diabetes and obesity are two major non-communicable diseases that are having a tremendous negative impact on the health and welfare of citizens in the United States and around the world. Despite considerable advances at the basic and clinical science levels, major unanswered questions regarding the pathogenesis of these disorders continue to limit our capacity to treat them. Effective training for scientists in diabetes, obesity and metabolic regulation are therefore fundamental priorities.

PI_NAMEs: MORTON, GREGORY J (contact);UTZSCHNEIDER, KRISTINA MARIE

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Diabetes, Obesity and Metabolism Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering

PHR: PROJECT NARRATIVE. Protein instability is the cause of many devastating and untreatable human diseases. We propose to build an exciting new technology for rapidly measuring protein stability, enabling screens for new therapeutics that correct these defects.

PI_NAMEs: GESTWICKI, JASON E (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: aerobic respiration control protein;Algorithms;Alzheimer's Disease;Benchmarking;Binding;Binding Proteins;Chemicals;cheminformatics;Chemistry;chromatin protein;Chromatin Remodeling Factor;Circular Dichroism;Clinical;Collaborations;Complex;conformational conversion;curve fitting;Cystic Fibrosis;Data;Data Analyses;Dedications;Defect;design;Differential Scanning Calorimetry;Disease;Drug Targeting;Dyes;enzyme activity;Equation;experimental study;Failure;Fluorescence;Goals;high throughput screening;high throughput technology;human disease;Hydrophobicity;improved;Individual;innovation;instrument;interest;Kinetics;Knowledge;Label;large datasets;Libraries;Ligand Binding;Link;Machine Learning;Measurement;Measures;melting;Membrane;metalloenzyme;Methods;Modality;Monitor;Multiprotein Complexes;Neurodegenerative Disorders;new technology;next generation;novel therapeutics;Nucleic Acid Binding;Oranges;Pharmaceutical Chemistry;Pilot Projects;Process;Property;protein complex;Protein Conformation;protein folding;protein misfolding;Proteins;public database;reconstitution;Reporting;Research;Role;Scanning;Series;simulation;skills;small molecule;Specificity;Structure-Activity Relationship;success;System;tau Proteins;Technology;Temperature;Testing;theories;Therapeutic;Time;VX-770;web portal;Work

PROJECT_TITLE: Differential Scanning Fluorimetry (DSF) Methods for Studying Protein Stability

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: NARRATIVE  Oral cavity squamous cell carcinoma (OCSCC) is a very aggressive and deadly disease with poor survival rates following maximal treatments such as surgery and chemoradiotherapy. Myeloid cells are thought to play an important role in head and neck cancer treatment resistance and the immunosuppressive tumor microenvironment. This proposal will test the hypothesis that a novel tumor derived RNA-nanoparticle vaccine can reprogram the myeloid cell compartment to unlock anti-tumor immunity; we will determine mechanisms of myeloid mediated vaccine efficacy in addition to checkpoint inhibitor synergy, and on the path towards human translation, we will evaluate the safety and efficacy of RNA-nanoparticle vaccines in client-owned felines with spontaneously occurring oral squamous cell carcinoma.

PI_NAMEs: SILVER, NATALIE LEA (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Antigen-Presenting Cells;antigen-specific T cells;Biology;Blood;Cancer Model;Cancer Patient;cancer recurrence;career;Cell Compartmentation;cell mediated immune response;Cell Physiology;Cell Proliferation;Cells;chemoradiation;Client;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;clinically significant;Collaborations;college;Dendritic Cells;design;Disease;Dose;effector T cell;Family Felidae;Felis catus;first-in-human;Genetic Transcription;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgeon;Head and Neck Surgery;Human;immune activation;immune checkpoint blockade;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immunity;Immunobiology;immunogenicity;Immunologics;Immunologist;Immunotherapy;improved;insight;Interferon Type II;Intravenous;Investigation;K-Series Research Career Programs;Knowledge;lipid nanoparticle;Macrophage;malignant mouth neoplasm;Mediating;Mediator;member;Mentors;Mentorship;Messenger RNA;Metastatic/Recurrent;Modeling;mouse model;mouth squamous cell carcinoma;Mus;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;novel;novel strategies;novel vaccines;oncology program;Operative Surgical Procedures;Outcome;Patient Care;patient population;Patients;Peripheral;pet animal;Phase;Play;pre-clinical;Pre-Clinical Model;Preclinical Drug Development;programmed cell death ligand 1;programs;Proliferating;Property;Recurrence;Regulatory T-Lymphocyte;Research;Research Personnel;response;RNA;Role;Safety;Scientist;Solid Neoplasm;Surgical Oncologist;Survival Rate;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Time;trafficking;Training;Training and Education;Translating;translational potential;Translational Research;translational scientist;Translations;tumor;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor Volume;Tumor-Derived;tumor-immune system interactions;vaccine efficacy;Vaccines;Veterinary Medicine;Work

PROJECT_TITLE: Remodeling host immunity in oral cancer with personalized RNA nanoparticle vaccines

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]