ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed Center for Cancer Systems Therapeutics (CaST) will seek to perform systematic, single-cell- level elucidation of stable cell states and state transitions in tumor-related cells and in their tumor microenvironment (TME) to identify and target complementary dependencies leading to mechanism-based combination therapy trials. This will provide a more holistic understanding of the fundamental steps underlying tumor initiation and progression and of the critical mechanisms that can be targeted pharmacologically to transform cancer treatment. Critically, we have shown that the Systems Biology framework developed by CaST Center investigators can effectively generalize to virtually any tumor of interest leading to highly innovative, biomarker-based interventional trials, thus accelerating progression from biological analysis to cures.

PI_NAMEs: CALIFANO, ANDREA  (contact);HONIG, BARRY H

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acceleration;actionable mutation;Address;Advanced Malignant Neoplasm;Behavior;Binding;Biological;Biological Markers;Buffers;cancer cell;Cancer Center;cancer therapy;cell type;Cells;Clinical;clinical translation;clinically relevant;Collaborations;Combined Modality Therapy;Dependence;design;Development;Disease-Free Survival;Dissection;drug mechanism;Drug resistance;Education;Endocrine;Epigenetic Process;Event;evidence base;Evolution;forging;Fostering;Genetic;Genetic Transcription;Goals;immune checkpoint blockade;Immunotherapy;improved;Individual;innovation;interest;Intervention;Intervention Trial;Ligands;Maintenance;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Methodology;Molecular;multiple data sources;multiple omics;Mutation;Network-based;next generation;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;Outcome;outreach;paracrine;patient responsibilities;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Printing;Productivity;Prognosis;programs;Proteome;Proteomics;Publications;receptor;receptor-mediated signaling;recruit;relapse patients;Research;Research Personnel;Reverse engineering;Science;Scientist;Signal Transduction;single cell technology;Structure;System;Systems Biology;Systems Integration;targeted treatment;Technology;Therapeutic;Therapy trial;three dimensional structure;Tissues;tumor;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;tumor-immune system interactions;Validation;virtual

PROJECT_TITLE: Studying the evolution of drug resistance in prostate cancer at the single cell level


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Pediatric;Substance Misuse

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The goal of R01DA054751 is to inform regulatory efforts to minimize cannabis use in disproportionately- impacted populations in states with legalized non-medical cannabis and those that subsequently legalize it, by examining the non-medical cannabis market, cannabis use, and related perceptions in market segments of diverse young adults within the context of diverse cannabis policies across states. The goal of the proposed Administrative Supplement is to expand on data collection in each aim of the parent R01 in order to assess derived psychoactive cannabis product (DPCP) laws, industry retail and marketing, and use in young adults. We will add: 1) comprehensive data on DPCP laws to our state cannabis-related law database; 2) DPCP retail audits to our planned cannabis retail audits to characterize the DPCP retail context; and 3) an additional wave of survey data collection for a subset of young adults in our longitudinal cohort study to assess differences in DPCP marketing exposure, DPCP perceptions and use motives, and use outcomes, by DPCP law context.

PI_NAMEs: BERG, CARLA J (contact);CAVAZOS-REHG, PATRICIA A

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Accounting;Address;Administrative Supplement;Adult;Advertising;Age;Agriculture;Area;Cannabis;Cannabis policy;Cannabis retail;Cities;cohort;Color;Complex;consumer behavior;Data;Data Collection;Data Set;Databases;Demography;Dryness;ethnic minority;experience;falls;Farm;Goals;Health;health warning;Hemp;high risk;Illicit Drugs;Industry;insight;Laws;Legal;Literature;Longitudinal cohort study;Marijuana;marijuana use;Marketing;Mediating;medical specialties;Medicine;Minor;Minority;Minority Status;National Institute of Drug Abuse;Neighborhoods;Outcome;outcome disparities;Parents;Participant;Penetration;Perception;Persons;Pharmaceutical Preparations;Poison Control Centers;Policies;Policy Compliance;Population;Prevalence;Prevention;Price;Product Labeling;Protocols documentation;public database;Public Health;public health research;racial minority;Recreation;Regulation;Reporting;Research;Research Activity;Research Priority;Safety;Sales;Smoke;Subgroup;substance use;Surveys;Tetrahydrocannabinol;Time;Tobacco;vaping;web site;Weight;Work;young adult;Youth

PROJECT_TITLE: Recreational Marijuana Marketing and Young Adult Consumer Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE To address high unmet need for postpartum family planning (PPFP) in Rwanda, we developed, and pilot tested our ‘C4’ intervention (informed by Couples/clients, Clinic providers, Champions, and Community health workers), which significantly increased the use of PPFP in government clinics. We now propose to use an implementation science framework to test the hypothesis that C4 is adaptable to large-scale implementation, cost-effective, and sustainable. C4 could dramatically reduce unintended pregnancy and abortion and improve birth spacing and maternal and newborn health.

PI_NAMEs: WALL, KRISTIN MARIE (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: abortion;Academic advising;acceptability and feasibility;Address;Adoption;Africa;Area;Birth Intervals;Breast Feeding;Capital;Chicago;Child;Cities;Client;Client satisfaction;Clinic;Communities;Community Health Aides;comparison intervention;Consolidated Framework for Implementation Research;Contraceptive methods;Contraceptive Usage;cost;cost effective;cost effectiveness;cost estimate;Cost Savings;Cost utility;Counseling;Country;Couples;Data;Decision Making;design;Diffusion;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Evaluation;experience;Family Planning;Family Planning Programs;Goals;Government;Happiness;Health;Health care facility;Implant;implementation cost;implementation framework;implementation process;improved;incremental cost-effectiveness;innovation;Intervention;Interview;Intrauterine Devices;low and middle-income countries;Maintenance;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neonatal health;neonatal morbidity;Neonatal Mortality;novel;Nurses;organizational readiness;Outcome;Patients;pilot test;Play;post pregnancy;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Prevention;Professional counselor;promoter;Provider;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;reversible contraceptive;Rwanda;Services;side effect;social;standard of care;Testing;theories;tool;unintended pregnancy;uptake;Woman;Women's Health;Work;World Health Organization;Zambia

PROJECT_TITLE: Implementation and evaluation of a large-scale postpartum family planning program in Rwanda


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE We discovered that brainstem neurons expressing anoctamin 4 (Ano4, an ion channel) regulate food intake and blood glucose in mice. A large-scale human genetic study established the association of the ANO4 gene mutation with human obesity, but the causality of this association has not been tested. Here we propose to use genetic mouse models to examine the effects of the Ano4 mutation and Ano4-expressing neurons on body weight and glucose homeostasis, which will provide the necessary framework to develop therapeutic strategies towards treating obesity and metabolic dysregulations.

PI_NAMEs: XU, YONG  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Acute;Affect;analog;Animal Experimentation;Animals;Behavior;Biological Models;Blood Glucose;blood glucose regulation;Body mass index;Body Weight;Brain;brain dysfunction;Brain Stem;Cardiovascular Diseases;Chronic;combat;comorbidity;Development;Diabetes Mellitus;dietary;DNA;dorsal motor nucleus;Eating;Equilibrium;Etiology;feeding;Feeding behaviors;gain of function;Gene Mutation;Genes;Genetic;Genetic study;genetic variant;global health;glucagon-like peptide 1;Glucose;Glutamates;Health;hindbrain;Hormonal;Human;Human body;Human Genetics;Hypothalamic structure;Ion Channel;Knock-in Mouse;Knowledge;Lateral;Long-Term Effects;loss of function;Malignant Neoplasms;Mediating;Medical;Mental Depression;Metabolic;Metabolic Diseases;Modeling;mouse model;Mus;Mutation;Nausea and Vomiting;Nervous System;neural circuit;neuromechanism;Neurons;novel;novel therapeutic intervention;novel therapeutics;Nucleus solitarius;Obesity;obesity development;obesogenic;optogenetics;parabrachial nucleus;Peptides;Physiological;Predisposition;Prevalence;Regulation;Research;response;Risk Factors;sensory integration;side effect;Signal Transduction;Structure;Structure of area postrema;Testing;Therapeutic;Variant;Viral;Viscera;Weight maintenance regimen

PROJECT_TITLE: Ano4 and Metabolic Health

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The Acquired Resistance to Therapy and Iron (ARTI) Center at The University of Texas MD Anderson Cancer Center will establish a foundation for understanding the role of iron in cancer resistance to therapies and will focus on deciphering the mechanisms of acquired resistance to radiation therapy, which can be extrapolated to other types of cancer therapy. The overarching goals of the ARTI Center are: 1) to bridge the basic science mechanism of a novel type of iron-dependent cell death called ferroptosis in acquired resistance to radiation therapy with translational research in preclinical models and human patient samples; 2) to identify cohorts of patients who are at greatest risk to develop acquired radiation therapy resistance; and 3) to investigate the ability of novel therapeutic agents to re-sensitize cancer cells to radiation by inducing ferroptosis. The long-term outcomes from the ARTI Center will foster collaborations with other centers in the Acquired Resistance to Therapy Network (ARTNet), build upon and iteratively feedback into research projects focused on drug resistance and sensitivities, and ultimately lead to cancer treatment strategies tailored to the individual patient.

PI_NAMEs: GAN, BOYI  (contact);LIN, STEVEN HSESHENG;LU, YI

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Achievement;activating transcription factor 4;Administrative Supplement;Advisory Committees;Basic Science;bioluminescence imaging;cancer cell;Cancer cell line;Cancer Center;cancer imaging;Cancer Patient;cancer therapy;cancer type;Cell Death;Cell Death Induction;Cells;chemoradiation;Clinical;Clinical Trials;clinically significant;Cloning;cohort;Collaborations;Communication;Cystine;Data;determinants of treatment resistance;Development;Drug resistance;drug sensitivity;effective therapy;Esophageal Adenocarcinoma;Failure;Family;Feedback;Fostering;Foundations;Future;Genes;Genomics;Goals;Grant;Guidelines;hormone therapy;Human;Hypoxia;Hypoxia Inducible Factor;Image;Imaging Device;imaging program;Immune;Immunologics;Immunotherapy;improved;individual patient;Infrastructure;Iron;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Mediating;Medical;member;Modality;Modeling;molecular imaging;Monitor;multidisciplinary;Mus;National Cancer Institute;Nature;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Patient-Focused Outcomes;Patients;Play;Policies;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Production;Prognostic Marker;programs;Radiation;Radiation Oncology;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;radioresistant;Reagent;Recurrence;Recurrent disease;Reporter Genes;Research;Research Project Grants;Resistance;Resource Sharing;Resources;Risk;Role;Sampling;single cell sequencing;solute;stable cell line;synergism;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Tracer;Transfection;Transgenic Organisms;Translating;Translational Research;treatment strategy;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Suppression;University of Texas M D Anderson Cancer Center;Xenograft Model

PROJECT_TITLE: Administrative Supplement: Investigating the role of iron redox dynamics in radiation resistance in esophageal cancer


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative There is strong evidence that disruption of neural circuit development and plasticity contributes to the etiology of many neurological and neurodegenerative disorders. The proposed experiments promise to increase our basic knowledge of the cellular and molecular mechanisms that drive neural circuit development in the mammalian cerebral cortex, refinement during learning, and alterations associated with disease. Ultimately, such basic knowledge has strong potential to facilitate the development of therapeutics for human neurological and neurodegenerative disorders.

PI_NAMEs: ZITO, KAREN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;Adult;Alzheimer's Disease;Alzheimer's disease model;Animals;Automobile Driving;Binding;Biochemical;Biosensor;Brain;calmodulin-dependent protein kinase II;Cell model;Cerebral cortex;Complex;Data;Dendrites;Dendritic Spines;density;Development;Disease;Environment;ephexin;Etiology;Excitatory Synapse;Exhibits;experience;experimental study;Family;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Functional disorder;Future;Glutamate Receptor;Glutamates;Goals;Growth;Health;hippocampal pyramidal neuron;Human;human disease;Image;Imaging Techniques;Impaired cognition;Intellectual functioning disability;Knowledge;Label;Learning;Measures;Mediating;Modification;Molecular;Molecular Genetics;Morphology;N-Methylaspartate;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Pathway interactions;Pattern;pharmacologic;Phosphotransferases;Play;Property;Protein Biochemistry;Proteomics;Regulation;Research Proposals;Resolution;response;rho GTP-Binding Proteins;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;Site;spatiotemporal;Study models;Synapses;Synaptic plasticity;synaptogenesis;Techniques;Testing;therapeutic development;two-photon;Vertebral column;Visualization

PROJECT_TITLE: Cellular and molecular mechanisms of dendritic spine growth and stabilization in health and disease

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative There is a critical need to develop accurate genetic risk prediction models for non-European populations because most studies to date have focused on individuals of European ancestry. This project will propose novel statistical methods to integrate data from diverse populations for more accurate risk prediction models in the underrepresented populations. Our developed tools, their applications to many diseases, and the associated dissemination platform will facilitate the translation of genome wide association study results into clinically useful disease risk prediction models in these populations.

PI_NAMEs: ZHAO, HONGYU  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;analysis pipeline;Bayesian Method;Benchmarking;Clinical;cohort;Complex;Data;data integration;design;Diagnosis;Disease;disorder risk;European;European ancestry;experience;flexibility;Generations;Genetic;genetic architecture;Genetic Risk;genetic variant;Genome;genome wide association study;Goals;Heritability;High Performance Computing;Human Genome;improved;Individual;Joints;large datasets;Medical Genetics;Methods;Modeling;Monitor;novel;parallelization;Participant;Performance;Population;Population Analysis;Population Heterogeneity;Prevention;Procedures;Prognosis;Publishing;recruit;Reduce health disparities;Research;Research Personnel;Risk;risk prediction;risk prediction model;Sampling;simulation;Standardization;Statistical Methods;statistics;Structure;Time;tool;trait;Translating;Translations;Underrepresented Populations;user-friendly;Validation;Variant;web server;Work

PROJECT_TITLE: Statistical Methods for Genetic Risk Predictions across Diverse Populations

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MEAGHER, KEVIN  (contact)

PROJECT_TERMS: Area;base;computer program;Data;data management;design;Development;Division of Cancer Prevention;Infrastructure;Services;System;website development

PROJECT_TITLE: BASE YEAR:  DATA COMPUTING SERVICES FOR DCP


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Clinical provider burnout is a key indicator of how well a health care system is functioning. Reducing mental health provider (MHP) burnout could improve patient access to care, quality of care, and improve employee engagement, which are core components of VHA's priorities and strategic plan. We propose to conduct the largest and most comprehensive study to date on the systematic, facility-level predictors and consequences of MHP burnout. VHA can use the findings from this longitudinal, mixed methods study to facilitative future planning and interventions to improve MHP burnout, employee engagement, and patient outcomes. Supported by a wide range of VHA and community partners and stakeholders, our findings could be of clinical and financial value to VHA, its providers, and patients. Our work will contribute to broad healthcare improvements within VHA, and will generate new insights for healthcare delivery, informing efforts to address burnout in MHPs and other clinical providers.

PI_NAMEs: ZIVIN, KARA  (contact)

PROJECT_TERMS: Address;Administrator;Area;Behavior;burnout;care delivery;Caregivers;Caring;Censuses;Characteristics;Clinical;community partners;contextual factors;Cross-Sectional Studies;Data;Data Analyses;Data Collection;Data Sources;Depersonalization;design;Development;direct patient care;Educational process of instructing;Emotional;Employee;Employee Engagement;Epidemic;Equipment and supply inventories;exhaustion;experience;Feedback;Feeling;Focus Groups;follow-up;Future;Health;health care delivery;Health Personnel;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hour;implementation study;improved;Individual;innovation;Inpatients;insight;Intervention;Interview;Job Satisfaction;Joints;Leadership;Learning;Light;Link;longitudinal analysis;Measures;Mediating;Mental Health;Mental Health Services;Methods;Mission;Monitor;Occupations;organizational climate;Outpatients;Patient risk;Patient-Focused Outcomes;Patients;Perception;Performance;Phase;Physicians;Policies;Prevalence;Primary Care Physician;Productivity;programs;Provider;provider factors;Psychiatric Hospitals;Psychiatrist;Psychologist;Qualifying;Quality of Care;Reaction;Recommendation;Reporting;Research;Research Personnel;research study;Resources;Risk Management;Sampling;satisfaction;Site;Social Workers;Specialist;Strategic Planning;stressor;Structure;Suicide prevention;Surveys;System;Testing;Time;Translating;Variant;Veterans;Wait Time;Work;Workplace

PROJECT_TITLE: Caring for the caregiver: predictors and consequences of VA mental health provider burnout

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: In the global HIV epidemic, Africa accounts for about 70% of the 38 million people living with HIV (PLHIV) and the 1.7 million new infections. In South Africa, which has a fifth of all the PLHIV in the world, the province of KwaZulu-Natal bears a disproportionate burden, with 2 million PLHIV. In this province, community-based adult HIV prevalence exceeds 30% and incidence rates exceed 4 per 100 person-years. KwaZulu-Natal also has a substantial tuberculosis burden, with 50,822 new cases of tuberculosis (incidence of 494 per 100,000) in 2018, of which about 60% are co-infected with HIV. The KwaZulu-Natal Clinical Trials Unit’s overall goal is to contribute to the scientific priorities of the four Clinical Trial Networks through novel research concepts, innovative prevention technologies and high-quality clinical trials in target populations by highly experienced research teams at well-equipped Clinical Research Sites.

PI_NAMEs: ABDOOL KARIM, QUARRAISHA  (contact)

PROGRAM_OFFICER_NAME: CASTILLO, BLANCA E

PROJECT_TERMS: Accreditation;Adolescent;Adult;Africa;AIDS prevention;Antibodies;Breast Feeding;Cessation of life;Child;Clinical;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Communication;Communication Tools;Communities;community advisory board;community engagement;Conduct Clinical Trials;data management;Data Management Resources;Decision Making;Enrollment;Ensure;Epidemic;Evaluation;experience;Funding;Goals;Health;high risk population;HIV;HIV prevention trial;HIV/TB;Incidence;Infection;Influentials;Infrastructure;innovation;Laboratories;Leadership;Medical Research;meetings;Monitor;Nevirapine;Newsletter;novel;novel strategies;organizational structure;Participant;Persons;Pharmacy facility;Policies;Politics;Population;Population Heterogeneity;pre-exposure prophylaxis;Pregnant Women;Prevalence;Prevention;Prophylactic treatment;Protocols documentation;Province;quality assurance;Research;Research Support;Resources;retention rate;Scientist;South Africa;South African;symposium;Target Populations;Technology;Tenofovir;Training;transmission process;treatment strategy;treatment trial;Tuberculosis;vaccine trial;web site;Work

PROJECT_TITLE: KwaZulu-Natal Clinical Trials Unit - Supplemental infrastructure request 2024


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Biotechnology;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative: Patients with type 1 diabetes (T1D) suffer a disproportionate higher risk of atherosclerosis and its consequences (e.g. heart attacks) remain the leading cause of morbidity and mortality in these patients. Emerging studies demonstrate important regulatory roles for non-coding RNAs in atherosclerosis, yet this is a poorly understood area of research in T1D. Our studies aim to fill this void by investigating the roles of key non-coding RNAs and their target genes and interactomes in cellular events important in the progression and regression phases of T1D-associated atherosclerosis, with the ultimate goal of developing innovative RNA-based therapies in the treatment of this devastating disease.

PI_NAMEs: FEINBERG, MARK W (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Acceleration;Antisense Oligonucleotides;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;atherosclerosis risk;biobank;Bioinformatics;Biological;Biological Assay;Biology;Blood Vessels;cardiovascular risk factor;Cardiovascular system;Cell Aging;cell type;Cells;Chemotaxis;Chronic;Cleavage Under Targets and Release Using Nuclease;Coronary artery;Coupled;crosslinking and immunoprecipitation sequencing;Data Set;Dependence;Development;Diabetes Mellitus;Diet;differential expression;Disease;DNA Damage;Endothelial Cells;Endothelium;Event;experience;Family suidae;gain of function;Genes;Genetic Transcription;Genome;Genomics;Goals;high risk;Human;human model;human subject;immune cell infiltrate;Impairment;in vitro Assay;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Insulin-Dependent Diabetes Mellitus;Investigation;Laboratories;Length;Lesion;Leukocytes;Link;Lipids;loss of function;Macrophage;Mass Spectrum Analysis;Mediator;Metabolic Pathway;Methylation;MicroRNAs;miRNA expression profiling;Mitochondria;Modeling;Molecular;molecular imaging;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Myocardial Infarction;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;open source;overexpression;Pathway interactions;Patients;pharmacologic;Phase;porcine model;Positioning Attribute;premature;Prevention;Prevention Measures;Process;Publishing;Qualifying;recruit;repository;Research;Research Personnel;Resistance;response;Risk;Role;Sampling;senescence;senescent cell;Severities;Signal Pathway;Signal Transduction;Specimen;sudden cardiac death;Sudden Death;Therapeutic;therapeutic RNA;therapeutic target;Tissue Sample;Transcript;transcriptome sequencing;transcriptomics;type I and type II diabetes;Untranslated RNA

PROJECT_TITLE: Discovery and therapeutic targeting non-coding RNAs in T1D- or T2D-associated atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-T (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PI_NAMEs: WONG, FRANK Y. (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;Behavioral Sciences;biobehavior;cohort;Committee Members;Communication;Communities;community engagement;Data;design;Development;diversity and inclusion;Education;Effectiveness;Ensure;Equity;evidence base;Faculty;Family;Florida;Fostering;Funding;Goals;Health;health determinants;health equity;Health Sciences;Individual;Infrastructure;innovation;Institution;Institutional Practice;Intervention;Lead;Leadership;Marketing;Mentors;Mentorship;Minority;Mission;Modeling;next generation;population health;Population Sciences;Procedures;Program Development;programs;recruit;Research;Research Infrastructure;Resources;Science;social;sociocultural determinant;Strategic Planning;Structure;Systems Theory;Teacher Professional Development;Testing;translational pipeline;Translational Research;Universities;Workforce Development

PROJECT_TITLE: Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-science Brigade


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: BIZON, CHRISTOPHER ;BRUSH, MATTHEW H. (contact);MUNGALL, CHRISTOPHER J

PROGRAM_OFFICER_NAME: BECK, TYLER

PROJECT_TERMS: Agreement;Algorithms;Aloral;Architecture;Autonomous Relay Agent;Biological;biomedical ontology;Collaborations;collaborative environment;Communication;Communities;Computer software;Consensus;Data;data lake;data modeling;data standards;design;Development;Disease;Documentation;Ensure;Infrastructure;innovation;Investments;Knowledge;knowledge graph;Libraries;Maps;Modeling;National Center for Advancing Translational Sciences;Nature;next generation;novel strategies;Ontology;Pharmaceutical Preparations;Phenotype;Process;Protocols documentation;Provider;Registries;Resources;Services;Source;Specific qualifier value;Standardization;System;Testing;Update;Validation;Voting;Work

PROJECT_TITLE: A Common Dialect for Infrastructure and Services in Translator


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Hypertension;Kidney Disease;Mental Health;Pain Research;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Pain and depression affect large percentages of the population and identifying the optimal medication for an individual can be challenging, so this trial will determine whether using genetic information to inform selection of opioids or antidepressants leads to better clinical outcomes for patients. People with African ancestry (AAs) have the highest rates of uncontrolled high blood pressure, chronic kidney disease and kidney failure, some of which is due to APOL1 genetic variants. We will test AA adults with high blood pressure for APOL1 and return the results to patients and their clinicians, to see if early knowledge of high genetic risk improves blood pressure, provider and patient behaviors and is cost effective.

PI_NAMEs: DEXTER, PAUL ;SKAAR, TODD C. (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Acute;Address;Administrative Supplement;Adult;Affect;African American population;African ancestry;anti-depressive agents;APOL1 gene;Behavior;Blood Pressure;Chronic Kidney Failure;chronic pain;Clinical;clinical care;Clinical Trials;cost effective;cost effectiveness;design;Diagnosis;Diffusion;disease disparity;economic impact;Foundations;Funding;genetic information;Genetic Risk;genetic testing;genetic variant;Genomic medicine;Genomics;Genotype;Grant;health care service utilization;health difference;Hypertension;hypertension control;improved;Indiana;Individual;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Mental Depression;method development;Methods;Opioid;Outcome;Pain;Participant;Patient Outcomes Assessments;Patient Recruitments;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacotherapy;Pilot Projects;Population;Population Heterogeneity;Postoperative Pain;Pragmatic clinical trial;pragmatic trial;primary endpoint;Provider;Randomized;recruit;Safety;secondary analysis;secondary outcome;Selection for Treatments;Test Result;Testing;Underserved Population;United States;Universities

PROJECT_TITLE: Implementing genomic medicine through pragmatic trials in diverse and underserved populations across Indiana.


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: VICKERS, SELWYN M (contact)

PROJECT_TERMS: Area;Arts;Biology;Biomedical Research;candidate selection;Cardiovascular Diseases;cohort;Collaborations;college;Communication;Communities;Decision Making;Development;Diabetes Mellitus;diversity and inclusion;Doctor of Philosophy;Ensure;Environment;environmental change;Equity;Faculty;Funding;Goals;Health Disparities Research;health disparity;Health Occupations;Health Services;Human Resources;improved;Infrastructure;Institution;Intervention;Interview;Leadership;Maintenance;Malignant Neoplasms;medical schools;Medicine;member;mid-career faculty;minority health;minority health disparity;Modeling;Neurosciences;Obesity;organizational climate;Personnel Management;Physician Executives;Policies;Positioning Attribute;Preventive Medicine;Process;professor;programs;Protocols documentation;Public Health;recruit;Reporting;Research;Resources;School Nursing;Science;Scientist;Secure;social;Strategic Planning;success;System;Travel;United States National Institutes of Health;Universities;Wages;web site

PROJECT_TITLE: UAB/TU FIRST Administrative Core


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact)

PROJECT_TERMS: Administrative Supplement;Award;Biomedical Research;Brain;Budgets;career development;climate data;cohort;Collaborations;Communicable Diseases;Communication;community building;Data;Dedications;design;Development;diversity and inclusion;emerging pathogen;empowerment;Ensure;Equity;Evaluation;evidence base;executive function;Faculty;Feedback;Fostering;Funding;global health;Goals;Health equity research;Human Resources;innovation;Institution;Leadership;Link;Malignant Neoplasms;medical schools;meetings;Microbiology;Mission;Monitor;National Cancer Institute;organizational climate;Process;Productivity;programs;recruit;Reporting;Research;research and development;Research Personnel;Research Support;Resource Sharing;Resources;Scientist;Strategic Planning;success;Surveys;Teacher Professional Development;Travel;U-Series Cooperative Agreements;Underrepresented Populations;United States National Institutes of Health;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PI_NAMEs: SIMON, MELISSA A. (contact)

PROJECT_TERMS: Acceleration;Accountability;Achievement;Administrator;Advisory Committees;Area;Behavior;Biomedical Research;Brain;Cardiovascular system;career;Cells;cohort;Collaborations;Communication;Communities;Development;diversity and inclusion;efficacy evaluation;Elements;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Goals;Grant;improved;Infrastructure;innovation;Institution;Investments;Knowledge;Lead;Leadership;Malignant Neoplasms;Mentors;Mentorship;Mind;Mission;Neighborhoods;Office of Administrative Management;operation;Outcome;Personal Satisfaction;Policies;Procedures;Process;Productivity;programs;Qualifying;Records;recruit;Research;Resource Allocation;Resource Development;Resources;role model;Shapes;Sister;Strategic Planning;Structure;success;synergism;Teacher Professional Development;tenure track;Time;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Work


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PI_NAMEs: REED, MARK BRIAN (contact)

PROJECT_TERMS: Acceleration;Accountability;addiction;Affect;American;Area;Biomedical Research;Charge;Climate;cohort;Collaborations;Color;Communication;Communities;community engagement;COVID-19 pandemic;COVID-19 vaccine;Development;Development Plans;Discrimination;Disparity;Doctor of Philosophy;Economics;Educational Curriculum;Educational Status;Ensure;Environmental Health;Equity;equity, diversity, and inclusion;ethnic diversity;Evaluation;evidence base;experience;Faculty;Faculty Recruitment;falls;Funding;gender diversity;Goals;Health;health disparity;Health Personnel;health science research;Health Sciences;higher education;Hispanic-serving Institution;Human;improved outcome;innovation;Institution;Institutionalization;interest;Knowledge;Latinx;Leadership;maltreatment;Medical;medical schools;Mentors;model development;Morbidity - disease rate;mortality;nutrition;Obesity;Operations Research;organizational climate;Outcomes Research;Persons;Physical activity;Population;Positioning Attribute;Principal Investigator;Process;Productivity;professor;programs;Public Health;racial diversity;Recording of previous events;recruit;Research;Research Personnel;Science;Scientific Advances and Accomplishments;skills;Social Work;STEM field;Structure;Students;success;synergism;Teacher Professional Development;tenure track;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: SDSU FUERTE: Administrative Core


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PI_NAMEs: SMITH, JANE ELLEN  (contact)

PROJECT_TERMS: Administrative Supplement;Adopted;Aging;American Indians;Area;Arts;Career Mobility;cohort;college;Communities;computational neuroscience;Data;Data Science;Department chair;design;Development;Development Plans;Discrimination;Ethnic Origin;Evaluation;evidence base;Faculty;Female;Funding;Goals;Graduate Enrollment;graduate student;Grant;Health;Hispanic;Hispanic-serving Institution;Human;improved;Individual;innovation;Institution;Institutionalization;interest;International;Lead;Leadership;life span;Mentors;Minority;minority scientist;minority trainee;Mission;model design;Modeling;Nervous System Disorder;neurochemistry;neurodevelopment;neuroimaging;Neurosciences;New Mexico;next generation;Outcome;Policies;Population;Positioning Attribute;precision medicine;Principal Investigator;Process;programs;racial diversity;recruit;Research;Research Activity;Research Personnel;Resources;role model;Science;Scientist;Students;success;Teacher Professional Development;tenure track;Testing;Training;Travel;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: UNM FIRST: Administrative Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: The University of Maryland School of Medicine (UMSOM) and the University of Maryland Baltimore County (UMBC) are submitting a joint application to the NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) program to recruit new faculty members from groups traditionally underrepresented (UR) in biomedical research. This consortium will use a model for faculty development and promotion that is based on the UMBC Meyerhoff Scholars Program, which has been highly in training undergraduates from UR groups who have gone on to careers in STEM (Science, Technology, Engineering, Medicine). The model will feature cluster hires of 10 new faculty in the areas of cancer biology, neuroscience and microbiology/immunology/infectious diseases, in which there is great institutional strength.

PI_NAMEs: KAPER, JAMES B (contact)

PROJECT_TERMS: Affect;Area;Baltimore;Biomedical Research;biomedical scientist;Cancer Biology;career;career development;cohort;Collaborations;Communicable Diseases;County;diversity and inclusion;Engineering;Ensure;Environment;equity, diversity, and inclusion;Evaluation;evidence base;expectation;experience;Faculty;faculty mentor;Faculty Recruitment;faculty support;Federal Government;Funding;Future;Goals;high school;Immunology;Individual;Infrastructure;Institution;Institutional Policy;Joints;junior high school;Leadership;Learning;Legal Rights;Maryland;Medical;medical schools;Medicine;member;Microbiology;Modeling;Monitor;Neurosciences;novel;outreach;Pathway interactions;Philosophy;Positioning Attribute;Postbaccalaureate;Procedures;Process;process improvement;professor;programs;Racial Equity;Recording of previous events;recruit;Research Personnel;Resources;Role;Scholars Program;Science;Series;Social Justice;sound;State Government;State Interests;Statutes and Laws;success;System;Talents;Teacher Professional Development;Technology;tenure track;Textiles;Thinking;tool;Training;Translating;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Administrative Core-UM First


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: TREJO, JOANN  (contact)

PROJECT_TERMS: Administrator;Adopted;Advanced Development;Advisory Committees;Affinity;Area;Biochemistry;Biological Sciences;Biomedical Research;California;Cardiovascular Diseases;career development;Chemistry;climate data;Cognitive Science;cohort;Collaborations;Collection;Communicable Diseases;Communication;Competence;Coupled;Data;Development;Disabled Persons;diversity and inclusion;Engineering;Ensure;Environment;equity, diversity, and inclusion;Ethnic Population;Evaluation;Evaluation Methodology;evidence base;Evidence based program;expectation;experience;Faculty;flexibility;Fostering;Funding;Goals;Grant;Health Sciences;Human;Immersion;Immunology;Individual;Infrastructure;Institution;Leadership;Longevity;Malignant Neoplasms;medical schools;Mentors;Mentorship;Methodology;Modeling;Neurosciences;Oceanography;operation;Organizational Change;Organizational Culture;outreach;Participant;Perception;Pharmacy facility;physical science;Process;Productivity;Program Development;Program Sustainability;programs;Protocols documentation;Public Health Schools;racial population;recruit;Research;research and development;Resources;retention rate;satisfaction;Schools;Science;Social Sciences;Strategic Planning;Structure;success;System;Teacher Professional Development;tool development;United States National Institutes of Health;Universities;Vision;Woman;Work

PROJECT_TITLE: UC San Diego FIRST Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative  Glucagon secretion from α-cells has long been viewed as primarily a counterregulatory mechanism – e.g. an agent that with a role to prevent blood sugar from decreasing t0 levels that compromise function. Our group, along with other researchers, have begun to identify a much more complex role for α-cells, raising questions about when and how glucagon may influence blood glucose levels. This proposal looks to detail proglucagon peptide secretion from α-cells and the impact this has on β-cell function and glucose tolerance, exclusively in preclinical studies of human islets and translational studies in human subjects.

PI_NAMEs: CAMPBELL, JONATHAN E (contact);D'ALESSIO, DAVID A.

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Age;Alpha Cell;antagonist;Arginine;Automobile Driving;Beta Cell;Blood Glucose;blood glucose regulation;Cell Communication;Cell Physiology;Cellular Stress;Circulation;Clinical Research;Compensation;Complex;Cross-Sectional Studies;Data;Dependence;Diabetes Mellitus;diabetes pathogenesis;diabetic;diet-induced obesity;Disease;Drug Controls;Equilibrium;Failure;Fasting;Functional disorder;Gender;GLP-I receptor;Glucagon;Glucagon Receptor;glucagon-like peptide 1;Glucose;glucose production;glucose tolerance;glycemic control;Health;Hepatic;Homeostasis;Hormones;Human;human subject;Hyperglycemia;Hypoglycemia;Impairment;in vivo;Individual;Infusion procedures;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Intake;interest;Interruption;Intravenous;islet;knock-down;Literature;Liver;Measures;Mediating;Metabolic;Metabolic stress;Metabolism;mouse model;Mus;neural;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;obese person;Obesity;Overweight;paracrine;Pathogenesis;Peptide Signal Sequences;Peptides;Peripheral;Persons;Physiological;Plasma;preclinical study;prevent;Process;Production;proglucagon;Proprotein Convertase 1;Proprotein Convertase 2;Publishing;Receptor Signaling;Regulation;Research Personnel;response;Role;Stimulus;Testing;Thinness;translational study;Weight;Work

PROJECT_TITLE: Alpha- to Beta-Cell Communication in Health and Disease

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that primarily affects older adults. The proposed study aimed to explore the molecular mechanisms underlying lung fibrosis associated with aging. The ultimate goal of the study is to develop novel therapeutic interventions for effective treatment of IPF.

PI_NAMEs: ZHOU, YONG  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acceleration;Acetylation;Acids;Acute Respiratory Distress Syndrome;Advanced Glycosylation End Products;Affect;Aging;aging related;aging reversal;Animal Experiments;antifibrotic treatment;Apoptosis;Apoptotic;Bleomycin;Blood;CD95 Antigens;Cells;Cessation of life;chemokine;Collagen;Collagen Fiber;crosslink;CX3CL1 gene;Death Domain;derepression;Development;Diabetes Mellitus;Digestion;Double Minutes;Eating;effective therapy;Effector Cell;Extracellular Matrix;Feedback;Fibrosis;fibrotic lung disease;Genes;glycation;Goals;Human;human subject;idiopathic pulmonary fibrosis;immunogenic;Impairment;Infiltration;inhibitor;Injury;Interstitial Collagenase;Lesion;Lung;Macrophage;Mechanics;Mediating;Molecular;mouse model;Mus;Myofibroblast;novel;novel therapeutic intervention;old mice;older adult;Oral Administration;Pathway interactions;Patients;Phagocytosis;polyacrylamide hydrogels;Predisposition;Production;programs;Pulmonary Fibrosis;receptor;recruit;Reporting;Resistance;Resolution;Risk Factors;Role;Signal Transduction;Slice;Solubility;Structure of parenchyma of lung;Testing;Time;Tissues;TP53 gene;treatment strategy

PROJECT_TITLE: Targeting Matrix Stiffness in Lung Fibrosis Associated with Aging

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Complementary and Integrative Health;Immunotherapy;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Data obtained from this proposal are expected to establish A-FABP as a novel therapeutic target and biomarker for HFD-induced obesity/breast cancer risk. This proposal will not only have basic science ramifications for understanding how A-FABP shapes dysregulated lipid metabolism and functions of TAMs and breast cancer cells, but will also have significant clinical implications for prevention and immunotherapy of obesity-associated BC.

PI_NAMEs: LI, BING  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Affect;Basic Science;Breast;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Risk Factor;cancer clinical trial;cancer immunotherapy;cancer risk;Cellular Metabolic Process;Chronic;Clinical;cocoa butter;Collaborations;conditional knockout;Consumption;Data;design;Development;diet-induced obesity;epidemiology study;extracellular;FABP4 gene;Fatty acid glycerol esters;fatty acid-binding proteins;Fish Oils;Funding Opportunities;Health;High Fat Diet;Holden Comprehensive Cancer Center at the University of Iowa;Human;humanized antibody;Immune;Immunosuppression;Immunotherapy;improved;Inflammation;insight;Insulin;Interleukin-6;Knockout Mice;Leptin;Link;Linoleic Acids;lipid metabolism;Lipids;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Mediating;Metabolic;metabolic profile;Modeling;Molecular;Molecular Chaperones;Monoclonal Antibodies;monocyte;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Obesity;Obesity associated cancer;obesity biomarkers;Oleic Acids;Olive oil preparation;Omega-3 Fatty Acids;oxidation;Palmitic Acids;Pathway interactions;PDL1 pathway;Peripheral;Phenotype;Physician Executives;Postmenopause;Prevention;Prevention strategy;programs;Regulation;Research;response;Risk;Role;Sampling;saturated fat;Serum;SETDB1 gene;Shapes;Source;Specimen;Therapeutic antibodies;therapeutic biomarker;Thinness;Tissues;Treatment Efficacy;tumor;tumor growth;Tumor-associated macrophages;tumorigenic;Unsaturated Fats;Woman;Xenograft procedure

PROJECT_TITLE: Determine the role of SETDB1 in controlling lipid metabolism in obesity-associated cancer


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Not applicable per RFA-RM-20-022

PI_NAMEs: AUGUST, AVERY  (contact)

PROJECT_TERMS: Academy;Acceleration;Advocacy;Bacteriology;Behavioral Sciences;Biological;Biology;Biomedical Engineering;career development;cohort;college;Complex;Development;early-career faculty;Environment;Epidemiology;Equity;Evaluation;evidence base;Faculty;faculty support;Fostering;Funding;Future Generations;health communication;health equity;Health Sciences;Immunology;Individual;Infection;Institution;Institutional Policy;Institutionalization;Interdisciplinary Study;interest;Mentors;Minority;Mission;Modeling;organizational climate;Positioning Attribute;Privatization;Process;professor;programs;Public Health;recruit;Research;Science;STEM career;success;System;Systems Biology;Testing;Underrepresented Populations;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Cornell FIRST Administration Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Oral cancer is a major public health concern, with 58,450 cases diagnosed in the US each year. Since current preventive and therapeutic approaches have not significantly improved oral cancer outcomes and could potentially be harmful, it is essential that alternative approaches to treatment be developed and tested. We will determine the impact of glucocorticoids and glucocorticoid signaling on oral cancer development, and the effects of the chemopreventive agent gallic acid on this pathway during oral cancer chemoprevention.

PI_NAMEs: OGHUMU, STEVE ONYEKA (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adjuvant Therapy;Affect;Anabolism;Animal Model;anti-tumor immune response;bioactive natural products;cancer cell;Cancer cell line;cancer chemoprevention;cancer infiltrating T cells;Cancer Patient;Cell Line;Cell Proliferation;Cells;Cessation of life;Chemoprevention;Chemopreventive Agent;Clinical;Clinical Chemoprevention;clinical practice;Complementary therapies;conditional knockout;conditional mutant;Coupled;Data;Development;Diagnosis;Down-Regulation;Endocrinology;Enzymes;Gallic acid;Gene Deletion;Gene Modified;Genetic;Glucocorticoid Receptor;Glucocorticoids;Goals;HPV negative;Human;Hydrocortisone;improved;in vivo;innovation;Intervention;Knockout Mice;Knowledge;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Metabolic Pathway;Metabolism;mouse model;Mouth Diseases;Mouth Neoplasms;Mus;Mutant Strains Mice;Neoplasm Metastasis;neoplastic cell;New Agents;novel;NR3C1 gene;Oral;oral cancer prevention;oral carcinogenesis;Oral mucous membrane structure;Outcome;Pathway interactions;Patients;Positioning Attribute;Postoperative Period;premalignant;prevent;Prevention strategy;Preventive;Public Health;public health relevance;Receptor Signaling;Regulation;Role;Sampling;Signal Transduction;Steroid biosynthesis;Survival Rate;System;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Treatment outcome;treatment strategy;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Infiltrating Lymphocytes;tumorigenesis;United States

PROJECT_TITLE: The oral glucocorticoid system in oral carcinogenesis and its modulation for improved treatment outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-L (02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  By 2050, osteoporosis is expected to affect >50% of Americans over the age of 50; further, osteoporotic hip fracture incidence is expected to increase by >200% compared to rates in 1990. Recent studies have identified a large number of loci associated with bone mineral density (BMD), an important clinical marker for osteoporosis diagnosis. This project aims to define causal genes at these loci to understand their biological mechanisms, and in turn, identify new drug targets for osteoporosis therapies.

PI_NAMEs: KWON, RONALD Y (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Affect;Age;American;Biological;Biology;Bone Density;bone mass;bone quality;Candidate Disease Gene;causal variant;Chronic Disease;Clinical;Clinical Markers;Diagnosis;Drug Targeting;gene discovery;gene function;Genes;Genetic;genetic analysis;genetic risk factor;Genetic Screening;genetic variant;genome wide association study;genome-wide;Genomic Segment;Goals;Health;Hip Fractures;Human Genetics;human genomics;in vivo;Incidence;innovation;loss of function;Meta-Analysis;Modeling;Molecular;Mus;new therapeutic target;novel;Osteoporosis;Osteoporotic;Phenotype;reverse genetics;skeletal;Testing;trait;Translating;virtual;Work;Zebrafish

PROJECT_TITLE: Causal Genes at BMD Loci

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

PHR: NARRATIVE Many hearing and language disorders arise from pathological alterations to the central auditory pathways. This study is relevant to public health since it will investigate the hitherto overlooked contralateral auditory tectothalamic pathways as a neural substrate in these disorders. Therefore, this research is relevant to part of NIH’s mission, since it develops the basic knowledge that will lead to improved methods for diagnosing, preventing, and treating auditory disorders associated with aging, development, trauma, and neurodegeneration.

PI_NAMEs: LEE, CHARLES C (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Aging;Auditory;auditory pathway;auditory processing;auditory stimulus;Auditory system;auditory thalamus;Behavior;behavioral impairment;Bilateral;Binaural;Binding;Brain;Brain Stem;cell type;Cells;Central Auditory Processing Disorder;Contralateral;Development;Diagnosis;Diagnostic;diagnostic development;diagnostic strategy;Disease;Ear;Equilibrium;Esthesia;experience;experimental study;Failure;Future;Glutamates;Goals;Health;Hearing problem;Impaired cognition;Impairment;improved;In Vitro;in vivo;Inferior;Inferior Colliculus;information processing;Injections;innovation;Investigation;Ipsilateral;Knowledge;Language Disorders;Lasers;life span;Light;Link;Medial geniculate body;Mediating;Methods;Midbrain structure;Mission;Modernization;Mus;Nerve Degeneration;neural;neural circuit;Neuroanatomy;neuromechanism;Neurons;neurophysiology;normal hearing;optogenetics;Outcome;Pathologic;Pathway interactions;Pattern;Physiological;Population;Presbycusis;prevent;Preventive measure;Process;Productivity;Property;prospective;Public Health;Quality of life;Research;response;Role;Scanning;Scheme;Signal Transduction;Slice;Societies;sound;Source;source localization;Stimulus;Structure;Synapses;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tinnitus;Tracer;Trauma;United States National Institutes of Health;Viral

PROJECT_TITLE: Bilateral integration of the auditory scene

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative One of the key causes of Parkinson’s disease is the misfolding of a protein called alpha-synuclein to form aggregates. In this application we propose to develop a new concept which uses some small structures referred to as nano scavengers to bind the misfolded protein and report on their presence (diagnosis) and accelerate their clearance from the brain (treatment).

PI_NAMEs: TANIFUM, ERIC  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acceleration;age related;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloidosis;Appearance;Area;Autophagocytosis;Behavior assessment;behavioral study;Benefits and Risks;Binding;Biological Markers;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;blood-brain barrier crossing;Bradykinesia;Brain;Brain imaging;Brain Stem;brain tissue;Cell Communication;Cell Line;Cells;Cerebrospinal Fluid;cerebrovascular;Clinical;Clinical Data;clinical diagnosis;Clinical Trials;clinically significant;Cognition;Cognitive;Complement Activation;Confocal Microscopy;contrast imaging;crosslink;Cytoplasmic Inclusion;Data;Dementia;Dementia with Lewy Bodies;Deposition;Detection;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic tool;Dimerization;disability;Disease;disease model;Disease Progression;Dose;efficacy testing;experience;Flow Cytometry;Formulation;Functional disorder;Funding;Gliosis;Grant;Histology;Housing;Human;Human Cell Line;Image;imaging agent;imaging probe;Impaired cognition;improved;In Vitro;in vivo;Individual;inhibitor;Injections;insight;Intervention;intravenous administration;Label;Lead;Lewy Bodies;Lewy body pathology;Lewy neurites;Ligands;Liposomes;Magnetic Resonance Imaging;Malaise;Mediating;Methods;Microglia;Midbrain structure;misfolded protein;Modeling;Molecular;Monoclonal Antibodies;motor deficit;motor symptom;mouse model;Mus;nano;Neocortex;Nerve Degeneration;neuroblastoma cell;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neuropathology;non-motor symptom;novel;novel diagnostics;novel therapeutic intervention;Olfactory Pathways;Onset of illness;Outcome;Parkinson Disease;Parkinson's Dementia;particle;Pathogenesis;Pathologic;Pathology;Patients;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phosphorylation;Pontine structure;pre-clinical;prevent;Process;prolyl oligopeptidase;Property;Prosencephalon;Proteins;Reporting;Rest Tremor;Safety;Senile Plaques;Severity of illness;Signal Transduction;Structure;Structure of choroid plexus;Substantia nigra structure;Symptoms;synucleinopathy;Tail;Tegmentum Mesencephali;Testing;theranostics;Therapeutic;tool;Transgenic Mice;Transgenic Organisms;Translational Research;treatment effect;Tretinoin;uptake;Variant;Veins;Virulent;X-Ray Computed Tomography

PROJECT_TITLE: CSF Oligomeric α-synuclein targeted nano scavengers as a Parkinson's disease theranostic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: OAKLAND

ORG_NAME: DIGITAL ORGANIZING POWER-BUILDING AND ENGAGEMENT LABS

ORG_STATE: CA

PHR: Project Narrative Structural racism is a fundamental cause of African American (AA) and Black Immigrant (BI) health disparities, but there is a lack of understanding of AAs and BIs lived experiences of structural racism and protective factors that mediate the impacts on Black Longevity. Our research contributes to filling the gap left by previous studies that have been slow to quantify and measure the impact of structural racism on Black longevity, by shedding new light on the extent to which compositional and contextual effects interact and impact differences in Black life expectancy across locations in the US. By adopting historical and life course perspectives we will: 1) co-design novel community-led quantitative and qualitative tools, measures, and data sets that more accurately capture the multifaceted nature of structural racism, its intersections with other systems of oppression, and its impact on Black longevity; and 2) develop agent-based models to dynamically assess factors that hinder or promote Black longevity across histories and geographies.

PI_NAMEs: AKOM, ANTWI AARON (contact);HEBERT-DEROUEN, MINDY C.;HEKLER, ERIC ;PERRY, ANDRE ;REHKOPF, DAVID H

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adopted;African American;African American population;Behavioral;Black Populations;Black race;Businesses;Characteristics;Code;Collection;Communities;community based participatory research;community organizations;Complex;County;Data;Data Collection;Data Set;Data Sources;Decision Making;design;Disparity;Education;Environmental Impact;Environmental Risk Factor;Equity;Expenditure;experience;Fathers;financial decision making;food desert;Funding;Future;Geography;Goals;Government;healing;Health;health data;health disparity;Health Status;Home;Household;Immigrant;improved;indexing;innovation;insight;Institution;intersectionality;Intervention;Left;Life Cycle Stages;Life Expectancy;Lived experience;Locales;Location;Longevity;low socioeconomic status;Measures;Mediating;member;Methods;mobile computing;Modeling;multiple data types;Nature;Neighborhoods;novel;Ownership;Perception;Police;Pollution;Population;Predictive Factor;promote resilience;protective factors;Race;racism;Recording of previous events;Reporting;Research;Research Methodology;residential segregation;resilience;resilience factor;Resources;Risk Factors;segregation;social;Social Environment;social factors;social relationships;structural determinants;Structural Racism;System;theories;Time;tool;Variant;Work

PROJECT_TITLE: The Black Zones: Harnessing Mobile Tech Enabled Community Driven Data, Big Population, Health Data, & Agent-Based Models to Transform the Measures & Metrics around Structural Racism & Black Longevity

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Individuals with obesity face a heightened risk of developing breast cancer. Our proposed research will test whether ceramides increase breast cancer growth and whether ceramide-lowering interventions might be suitable for these patients. Thus, the proposed research is of high relevance to public health and perfectly aligns with NCI mission to support cancer research by advancing scientific knowledge and helping people live longer, healthier lives.

PI_NAMEs: CHAIX, AMANDINE H.;SUMMERS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Affect;Anabolism;Animal Model;anti-cancer research;Apolipoprotein E;Biological Models;Biology;Biomass;Body Weight decreased;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Risk Factor;Cancer Cell Growth;cancer risk;cancer type;Cancerous;Carbohydrates;cell type;Cells;Ceramides;Chronic;Clinical;cohort;Colorectal Cancer;combat;Complex;Data;Development;diet-induced obesity;Dietary Fats;Dietary Intervention;Environment;Face;Fatty acid glycerol esters;Fatty Acids;Female;Fostering;Future;Glucose;Goals;Growth;Human;Hyperinsulinism;in vivo;Incidence;Individual;Insulin;Insulin Resistance;Intervention;Intestines;ketogenic diet;Knock-out;Knowledge;Lesion;Link;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Menopausal Status;Metabolic;Metabolic dysfunction;Metabolic syndrome;Mission;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Nucleotides;Nutrient;Nutrient availability;nutrition;Obesity;obesity treatment;Outcome;oxidation;Parents;Pathway interactions;Patients;Persons;Physiology;Postmenopause;premalignant;progenitor;programs;Proteins;Public Health;Publishing;Recurrence;Research;Research Proposals;Resources;Risk;saturated fat;Scientific Advances and Accomplishments;Serum;Signal Transduction;Sphingolipids;stable isotope;System;Testing;Therapeutic Intervention;Thinness;Transgenic Mice;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor metabolism;tumor progression;uptake;Utah;Woman;Work

PROJECT_TITLE: Ceramides as novel drivers of metabolic dysfunction and colorectal cancer


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Natural Products;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_NAME: ARMIDA LABS, INC.

PHR: PROJECT NARRATIVE We propose to target a specific tumor marker, EphA2, expressed on the surface of aggressive pancreatic cancers. We propose to develop our potent and effective EphA2 targeting agent, Targefrin, that effectively inhibits tumor metastases. We will also probe Targefrin as an effective drug deliver agent to target chemotherapy selectively to the tumor and circulating cancer cells. Hence the proposed therapeutic strategy would simultaneously eliminate the primary tumor and suppress pancreatic cancer metastases.

PI_NAMEs: BAGGIO, CARLO  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Abraxane;Adult;Affinity;Albumins;anti-cancer;Azoles;Binding;Biological Sciences;Biopsy;Breast;cancer cell;Cell Line;cell motility;chemotherapeutic agent;chemotherapy;circulating cancer cell;Clinical;Clinical Research;Clinical Trials;Cytotoxic agent;design;Detection;Development;diagnostic strategy;Dose;Drug Targeting;efficacy study;End Point Assay;EphA2 Receptor;Esters;Evaluation;FDA approved;first-in-human;Formulation;Future;gemcitabine;imaging study;in vivo;in vivo imaging;in vivo Model;innovation;Invaded;Investigational Therapies;Letters;Ligands;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Names;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel diagnostics;novel therapeutic intervention;Oncogenic;Oncologist;Organ;overexpression;Paclitaxel;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic neoplasm;Patient Selection;Patients;Penetration;Pharmaceutical Preparations;pharmacologic;Phase;Primary Neoplasm;Prognosis;Property;Prostate;Protocols documentation;receptor;Receptor Cell;receptor internalization;Receptor Protein-Tyrosine Kinases;Reporting;Research Personnel;Serum;Side;Signal Transduction;Site;Small Business Innovation Research Grant;Solid Neoplasm;standard of care;Surface;Surrogate Endpoint;targeted agent;targeted treatment;Testing;Therapeutic;Tissues;Toxic effect;tumor;Tumor Markers

PROJECT_TITLE: Targeting pancreatic cancer metastases with Targefrin


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Our research investigates why type 1 diabetes significantly raises heart disease risk. Unlike type 2 diabetes, type 1 involves unique cardiovascular complications not fully explained by usual risk factors. We suspect that diabetes-related immune system irregularities contribute to heart issues. By analyzing immune and heart tissue differences in diabetic versus non-diabetic individuals, we aim to pinpoint these immune interactions' role in heart disease, potentially leading to new treatments that can lower heart disease risk in diabetes patients.

PI_NAMEs: CIVELEK, METE  (contact);MILLER, CLINT L;ONENGUT, SUNA

PROJECT_TERMS: Academic Medical Centers;adipokines;Affect;Anterior Descending Coronary Artery;Applications Grants;Area;Arterial Fatty Streak;Atherosclerosis;Autoantibodies;Autoimmune Diabetes;autoimmune inflammation;Autoimmune Responses;biobank;Blood Vessels;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Cell Communication;Cell Surface Proteins;cell type;Cell Wall;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic;cohort;Collaborations;Communities;Coronary;Coronary artery;Data;Data Set;Death Rate;Development;Diabetes Mellitus;diabetic;diabetic patient;digital pathology;disease model;Disease Progression;Exhibits;experimental study;Fostering;gain of function;Gene Expression;Genes;Genetic;Genetic Diseases;genetic risk factor;Genetic Transcription;Heart;heart disease risk;Heart Diseases;High Prevalence;Histology;Human;Hyperglycemia;Hyperlipidemia;Hypertension;Immune;Immune system;Immunohistochemistry;In Vitro;Individual;Inflammation;Inflammatory;inflammatory milieu;innovation;insight;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Interleukin-1;Interleukin-6;Intervention;Joints;Laboratories;Left;Lentivirus;Lesion;life span;Lipids;loss of function;Measures;Mediating;member;Metabolic;Molecular;molecular phenotype;molecular targeted therapies;multiple omics;Nature;Necrosis;network models;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome Study;particle;Pathologic;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;preservation;Process;Proteins;Publications;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Role;Sampling;Senile Plaques;Serum;Serum Proteins;single cell technology;Specimen;Testing;Therapeutic Intervention;tissue resource;Tissues;TNF gene;transcriptome sequencing;type I and type II diabetes;Universities;user-friendly;Variant;Virginia;web site;whole slide imaging

PROJECT_TITLE: Molecular Drivers of Atherosclerosis in Diabetes


NIH_SPENDING_CATS: Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative. Despite the identification of numerous genes and variants associated with type 2 diabetes (T2D) through genome-wide association studies (GWAS), the interaction network of these GWAS-identified T2D genes/variants remains poorly understood. This proposal aims to use stem cell-derived islet organoids and human islets to systematically evaluate the molecular cascade involving T2D effector genes and variants in human islet cell generation, survival, and function. These proposed studies will not only address several challenges encountered in current T2D GWAS studies but also shed light on new insights into T2D disease progression.

PI_NAMEs: CHEN, SHUIBING  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Address;Allelic Imbalance;Automobile Driving;Beta Cell;Binding;Biochemical;Biological Models;Biological Process;Cell Differentiation process;cell injury;Cell Physiology;Cell Survival;Cells;Chromatin;Complex;CRISPR/Cas technology;Defect;Development;differentiation protocol;Disease;Disease Progression;DNA Binding;DNA Binding Domain;Endocrine;Epigenetic Process;Etiology;Functional disorder;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;Health;Human;human embryonic stem cell;human pluripotent stem cell;Impairment;In Vitro;in vitro Model;in vivo;Individual;insight;Insulin;insulin secretion;islet;Islet Cell;Islets of Langerhans;Light;Link;Maps;Measures;Mediating;Molecular;Non-Insulin-Dependent Diabetes Mellitus;Organoids;Outcome;overexpression;Production;Publishing;Quantitative Reverse Transcriptase PCR;response;RFX1;RFX3;risk variant;Role;Scheme;Signal Transduction;single-cell RNA sequencing;stem cells;success;System;Therapeutic Intervention;Tissues;Trimethoprim;Variant;WFS1 gene

PROJECT_TITLE: Functional Interrogation of Type 2 Diabetes-associated Genetic Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Precision Medicine

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Molecular details for understanding disease and injury of the musculoskeletal system are particularly needed to develop novel proteomic assays to monitor disease progression in osteoarthritis or meniscal injury. Our innovative approach includes developing Spatial Mass Spectrometry Imaging technologies for joints to spatially visualize proteins of the extracellular matrix and glycans, and applying deep proteomic profiling for bones using robust statistical tests. These technologically novel approaches will also facilitate the development of urgently needed molecular assays to assess efficacy of interventions for the musculoskeletal system.

PI_NAMEs: ALLISTON, TAMARA N;ANGEL, PEGGI M;SCHILLING, BIRGIT  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: advanced disease;Age;age related;age related changes;Aging;Area;articular cartilage;Automobile Driving;Biological;Biological Assay;Biological Markers;Biology;bone;Bone Diseases;burden of illness;Cartilage;Cartilage injury;Charge;Clinical;Collagen;Communities;curative treatments;Data Set;Defect;Degenerative Disorder;Degenerative polyarthritis;Development;Disease;Disease Progression;efficacy evaluation;extend lifespan;Extracellular Matrix;Extracellular Matrix Proteins;functional decline;Functional disorder;Future;Global Change;Health;Heterogeneity;Human;Image;Imaging Device;imaging modality;Imaging technology;Individual;Injury;innovation;innovative technologies;insight;Intervention;joint destruction;joint injury;Joints;Knee;Knee joint;Knee Osteoarthritis;Knowledge;Lateral;Libraries;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Medial;Medical;meniscus injury;meter;mineralization;Molecular;molecular imaging;Molecular Profiling;Monitor;Mus;Musculoskeletal;musculoskeletal injury;Musculoskeletal System;new technology;novel;novel diagnostics;novel marker;novel strategies;Obesity;Operative Surgical Procedures;Organ;Orthopedics;Palliative Care;Pathologic;Pathology;Pathway interactions;Peptide Library;Polysaccharides;Post-Translational Protein Processing;precision medicine;protein biomarkers;Proteins;Proteome;proteomic signature;Proteomics;Protocols documentation;Public Health;Reaction;Replacement Arthroplasty;Reporting;Resolution;Risk;Risk Factors;San Francisco;Sclerosis;senescence;sex;Side;Slice;Slide;South Carolina;Spatial Distribution;spatial integration;subchondral bone;Synovial Fluid;tandem mass spectrometry;targeted biomarker;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;Tissues;tool;Treatment Efficacy;United States;Universities;Visualization;Work;World Health Organization

PROJECT_TITLE: Spatial Proteomics of osteoarthritis in bones to uncover disease progression

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative The efforts outlined will increase the likelihood of MOSAAIC cohort success in recruitment and retention and strengthen elements of the core protocol by expanding selected core data, ensuring greater standardization across sites, and assessing the reliability of the novel data collection.

PI_NAMEs: ANDERSON, GARNET L. (contact);CHAN, KWUN CHUEN GARY ;FLOYD, JAMES S;KAPLAN, ROBERT C

PROGRAM_OFFICER_NAME: SANTOS, STEPHANIE

PROJECT_TERMS: Address;adjudication;Administrative Supplement;Age;aged;Anthropometry;Asian;Asian Americans;Asian population;Baseline Surveys;Behavioral;Biological;Biological Markers;Birth Place;Blood;Blood Pressure;Bronchodilation;Bronchodilator Agents;cardiometabolism;Clinic Visits;Clinical;cohort;Cohort Studies;Collaborations;Collection;Communities;community engagement;Community Outreach;cost;Country;Data;data acquisition;Data Collection;data harmonization;Databases;Demographic Survey;Dietary Assessment;Electrocardiogram;Elements;Eligibility Determination;Ensure;Environmental Exposure;Epidemiology;Equipment;Event;Family;Feasibility Studies;Feces;follow-up;Funding;Goals;Health;health disparity;Heart failure;improved;Incentives;Incidence;Individual;interest;International;Knowledge;Label;Language;Link;Longevity;Longitudinal cohort;Longitudinal Studies;Longterm Follow-up;Measures;Medical;Medical Records;Mental Health;Methods;multi-ethnic;Myocardial Infarction;National Heart, Lung, and Blood Institute;Native Hawaiian;Native Hawaiian or Other Pacific Islander;novel;Nutrient;nutrition;Nutrition Assessment;Observational Study;organizational structure;Outcome;Pacific Islander;Pacific Islands;Participant;participant retention;Patient Recruitments;payment;Peripheral Blood Mononuclear Cell;Phase;Prevalence;Printing;Procedures;Protocols documentation;pulmonary function;quality assurance;Questionnaires;recruit;Reduce health disparities;Research;Research Design;Research Personnel;retention rate;Risk Factors;Saliva;Sample Size;Sampling;Site;social;Spirometry;Standardization;stool sample;Stroke;success;Testing;United States;Update;Urine

PROJECT_TITLE: Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) Administrative Supplement


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2025 Myogenesis Gordon Research Conference will bring together basic and applied muscle researchers from around the world to exchange information on the latest conceptual advances in skeletal muscle research. Topics to be covered include Regulation of Gene Expression in Muscle; Muscle Diseases and Therapies; The Muscle Stem Cell Niche; Physiological Regulation of Myogenesis; Development of Muscle and Associated Tissues; Muscle Diseases and Therapies; Aging in Health and Disease; and Innovations in Muscle Research. The health relatedness of this application comes from the focus on unpublished research to be shared by our speakers which will be used to advance our understanding of mechanisms regulating muscle health.

PI_NAMEs: CORNELISON, DAWN D (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Area;Atmosphere;Award;Biology;career;Career Choice;cell type;cohort;Collaborations;Communication;community building;Creativeness;Data;Defect;Development;Disease;Education;Ensure;Epigenetic Process;Event;Feedback;Functional disorder;Gene Expression Regulation;Genetic;Goals;graduate student;Health;Homeostasis;Human;in vivo;Injury;innovation;insight;interest;International;Invertebrates;Italy;life span;Maintenance;meetings;member;Mentors;Minority;Modeling;Muscle;Muscle Development;muscle form;Muscle function;muscle progenitor cell;Muscular Atrophy;myogenesis;Myopathy;Natural regeneration;next generation;Oral;Participant;Pathology;Pathway interactions;peer;Physiological;place fields;Positioning Attribute;Postdoctoral Fellow;posters;Process;programs;Quality of life;Regulation;Relaxation;Renaissance;Reporting;Request for Proposals;Research;Research Personnel;Resort;Role;Schedule;Scientist;Senior Scientist;Series;Skeletal Muscle;social;stem cell niche;stem cells;symposium;Thinking;Tissues;Woman;Work

PROJECT_TITLE: 2025 Myogenesis Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: U54 CENTER: NARRATIVE Metastatic organ colonization by circulating tumor cells depends on a response program in tumor cells, termed mechano-adaptation, to cope with mechanical and molecular stresses. In this U54 MetNet Center, we will integrate mechanical, genomic and ultrastructural information during metatastatic organ colonization and identify mechanical mechanisms of tumor cell fate decisions and identify pathways and potential therapeutic strategies to eliminate tumor cells prior to metastasis.

PI_NAMEs: KAMM, ROGER D (contact);SHENOY, VIVEK

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Adhesives;Affect;Basement membrane;Biological Assay;Blood Platelets;Breast Melanoma;cell behavior;Cell Communication;Cell Death;Cell Survival;cell type;Cells;Cessation of life;Chromatin;Chromatin Structure;Circulation;colorectal cancer metastasis;Complex;Computer Analysis;computer studies;coping;Cytoskeleton;Dermis;Disease;Disseminated Malignant Neoplasm;Endothelium;Environment;experience;experimental study;Extracellular Matrix;Extravasation;Fibrin;Gene Expression;Genomics;Goals;hemodynamics;Image;In Vitro;in vitro Model;in vivo;Individual;insight;Intervention;intravital imaging;Liver;Macrophage;Malignant Neoplasms;Measurement;Mechanics;metastatic process;Methods;Microcirculation;migration;Modeling;Molecular;monolayer;mortality;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Nuclear;Organ;Organ Specificity;Pathway interactions;Phenotype;prevent;Primary Neoplasm;Probability;Process;programs;Proliferating;Property;Resolution;response;Role;shear stress;Site;Stress;stressor;Techniques;Technology;Therapeutic;Thrombus;Time;Tissues;transcriptome;transcriptomics;triple-negative invasive breast carcinoma;Tumor Cell Invasion;Vision;Work

PROJECT_TITLE: Delineating the role of SPP1+ macrophages in colorectal cancer metastasis


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative  Correlation between antimicrobial susceptibility phenotypes and presence of major groups of antimicrobial resistance genes will be studied. Different mutation types, including point mutations, insertion and deletions, as well as potential segment rearrangement, and mutation rate of each type will be analyzed. Additionally, genetic diversity and phylogenetic relationships of the major AMR genes as well as potential correlation of AMR susceptibility levels to AMR gene diversity will also be studied.

PI_NAMEs: BAI, JIANFA  (contact)

PROGRAM_OFFICER_NAME: MILLER, MEGAN

PROJECT_TITLE: Assessing correlation between antimicrobial resistance genes and susceptibility phenotypes for Enterobacter cloacae complex isolates from the Vet-LIRN AMR monitoring program and clinical samples

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (02)]


PHR: NARRATIVE Obesity is associated with changes in immune responses in fat tissue, which may contribute to the development of type 2 diabetes. In this application, we propose to investigate how to improve fat tissue immune responses to protect our bodies from the effects of obesity. At the end of our studies, we expect to uncover new ways to improve the immune system to treat obesity and type 2 diabetes.

PI_NAMEs: HARTIG, SEAN ;WU, HUAIZHU  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipocytes;Adipose tissue;Animal Model;Antigen-Antibody Complex;Body mass index;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cells;Clinical Trials;Closure by clamp;comorbidity;Cytoprotection;Data;Development;Diet;diet-induced obesity;dietary;Fatty acid glycerol esters;Flow Cytometry;Follow-Up Studies;Fostering;FOXP3 gene;gain of function;Genetically Modified Animals;Goals;High Fat Diet;high risk;Homeostasis;Immune;Immune response;Immune system;Immunophenotyping;Immunotherapy;improved;Inflammation;Inflammatory;insight;Insulin Resistance;insulin sensitivity;Knock-out;Knowledge;loss of function;Mediating;Metabolic;Metabolic Diseases;Metabolism;MicroRNAs;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obese Mice;obese person;Obesity;Olive oil preparation;Outcome;overexpression;Pathway interactions;Persons;Phenotype;Play;pre-clinical;Pre-Clinical Model;Prevention;Regulation;Regulatory T-Lymphocyte;Reporting;Research;response;Rodent Model;Role;saturated fat;Shapes;STAT1 gene;T-Lymphocyte;Testing;therapeutic target;Thinness;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomics;Unsaturated Fats;Wild Type Mouse

PROJECT_TITLE: MICRORNA REGULATION OF ADIPOSE TISSUE IMMUNE RESPONSE IN OBESITY

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: For this administrative supplement, the Administrative Core will play an important role in helping close out this cycle of the grant with final enrollment and research visits being completed over the extended final year of the grant. The research team, including the study coordinators and the program manager will be focusing on completed these research visits and performing data cleaning. The datasets will be prepared for analysis which will be led by the biostatistician included in the core and other investigators interested in specific analysis, and more specifically, the EEG team and lead investigator who will help complete EEG enrollment and study visits, and finalize the data analysis related to EEG. Page 295 Project Summary/Abstract

PI_NAMEs: SAHIN, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Administrative Efficiency;Administrative Supplement;Advisory Committees;Award;Biological Markers;career;Clinical Research;clinical research site;Collaborations;Communication;Communities;cost effective;Data Analyses;data cleaning;Data Set;data sharing;design;Development;Electroencephalography;Enrollment;Environment;experience;Funding;Goals;Grant;interest;Lead;Leadership;meetings;Mutation;Neuropsychology;operation;patient advocacy group;Patients;Physicians;Play;Process;programs;PTEN gene;Rare Diseases;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;Structure;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Developmental Synaptopathies Associated with TSC, PTEN and SHANK3 Mutations - supplement #3


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Neuropathic pain is a debilitating form of chronic pain afflicting millions of patients worldwide but is poorly responsive to current analgesic therapies. It is hypothesized that increased excitatory/decreased inhibitory signaling in the dorsal horn of the spinal cord results in the initiation, maintenance, and progression of neuropathic pain. This study uses in vivo intraspinal optogenetics, conditional genetic knockout lines combined with behavioral pharmacology, and spinal cord slice electrophysiology to ultimately determine if peripheral nerve injury increases the excitability of excitatory dorsal horn interneurons (those that contain the type 1 receptor for neuropeptide Y) to contribute to the behavioral manifestations of neuropathic pain.

PI_NAMEs: NELSON, TYLER SCOTT (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;Absence of pain sensation;Address;Affect;Afferent Neurons;Agonist;Amygdaloid structure;Analgesics;aspirate;Behavior;behavior test;Behavioral;behavioral pharmacology;Behavioral Symptoms;Brain;Brain region;Cells;chronic pain;chronic painful condition;Complex;Coupled;Data;Data Set;Development;Disease;dorsal horn;Educational process of instructing;Electrophysiology (science);Equilibrium;experience;Family;Fellowship;Fluorescent in Situ Hybridization;Frequencies;General Population;Genes;Genetic;Genetic Techniques;Glutamates;Goals;healing;Immediate-Early Genes;improved;in vivo;in vivo calcium imaging;inflammatory pain;Injury;Institution;Interneurons;Knock-out;Label;Laboratories;Learning;Lesion;Maintenance;Measures;Mediating;Mentors;Mentorship;Messenger RNA;Methods;mouse model;Mus;National Research Service Awards;nerve injury;neural;Neurobiology;Neurons;neuropeptide Y;Neuropeptide Y Receptor;neuropeptide Y-Y1 receptor;Neuropeptides;Neurosciences;neurotransmission;Nociception;Nociceptors;novel strategies;Nucleosomes;Opioid;optogenetics;Output;Pain;pain perception;painful neuropathy;parabrachial nucleus;patch clamp;Pathologic;Patients;Peripheral;Peripheral nerve injury;Pharmacology;Phase;Physiological;Population;Positioning Attribute;Postdoctoral Fellow;postsynaptic;presynaptic;Principal Investigator;Proteins;Quality of life;receptor;Reporting;Research;Research Personnel;Role;segregation;sham surgery;Signal Transduction;single-cell RNA sequencing;skills;Slice;Societies;somatosensory;Spinal;Spinal Cord;Spinal cord posterior horn;Stimulus;System;Techniques;Technology;temporal measurement;tenure track;Testing;Therapeutic;Tissues;Training;transcriptome sequencing;transcriptomics;United States;Universities;voltage clamp;wireless;Work;Writing

PROJECT_TITLE: Dissecting the Parabrachial Nucleus's Role in the Development and Maintenance of Neuropathic Pain


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteoarthritis;Regenerative Medicine

PHR: Project Narrative Diseases of the cartilage and joints, including osteoarthritis, are a leading cause of disability in the world, disproportionally affecting women and minorities. Osteoarthritis alone affects approximately 7% of the population worldwide and results in significantly reduced quality of life and negative economic impact, affecting gross national product from 1 to 2.5% in countries with market economies, and the impact of these conditions is expected to rise as life expectancy increases. The primary objective of this meeting is to provide a unique venue to present and discuss interdisciplinary research with an emphasis on exposing new investigators to innovations in cartilage and joint development, maintenance and pathology, bioengineering, and translational research, which will have the potential to impact public health in the area of cartilage-related diseases, including osteoarthritis.

PI_NAMEs: SERRA, ROSA A. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Adult;Affect;Area;arthropathies;articular cartilage;Articulation;base;Basic Science;Biological;Biology;Biomechanics;Biomedical Engineering;bone;California;career;Career Choice;Cartilage;cartilage degradation;cartilage development;Cartilage Diseases;Cell Therapy;Clinical Research;Collaborations;collaborative environment;Country;Dedications;Degenerative polyarthritis;design;Development;disability;Discipline;Disease;Disproportionately impacts women;Economic Burden;economic impact;Economics;Elastic Cartilage;Embryonic Development;Emerging Technologies;empowerment;Engineering;Environment;epigenomics;Epiphysial cartilage;Evolution;Extracellular Matrix;Failure;Feedback;Fibrocartilages;Fostering;Functional disorder;gene therapy;Genes;Genomics;Goals;Grant;Gross National Product;Growth;Growth and Development function;Health;Hour;Human;improved;Individual;innovation;insight;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Joints;Knowledge;Learning;Life Expectancy;life span;Link;Maintenance;malformation;Marketing;Mechanics;meetings;Mentors;Minority;Musculoskeletal;next generation;novel;novel therapeutics;Operative Surgical Procedures;outreach;Pain Free;Participant;Pathology;peer;pharmacologic;Pharmacological Treatment;Physiologic Ossification;Population;Postdoctoral Fellow;posters;Prevention;Process;Productivity;programs;Public Health;Quality of life;regenerative therapy;regenerative treatment;Reporting;Research;Research Personnel;Resources;Running;Scholarship;Scientist;Series;Signal Transduction;skeletal;Skeletal Development;skeletal disorder;Skeletal system;socioeconomics;stem cell biology;student participation;success;Surface;symposium;Talents;Technology;Therapeutic;Time;Tissue Engineering;Tissues;Translational Research;treatment strategy;Underrepresented Minority;Vertebrates;Woman;Work;Writing

PROJECT_TITLE: 2025 Cartilage Biology and Pathology Gordon Research Conference and Gordon Research Seminar


PHR: Narrative This proposal will elucidate how excessive free hemoglobin in circulation binds to von Willebrand factor (VWF) and alters the interaction between VWF and fibrinogen at very high flow conditions. This project will also characterize the function of VWF derived from platelets in the presence of elevated levels of hemoglobin. The proposed work will lay the foundation for the development of anti-thrombotic agents targeting the VWF-hemoglobin interaction.

PI_NAMEs: CRUZ, MIGUEL ANGEL (contact);YEE, ANDREW

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Adhesions;Adsorption;age group;Antibodies;Anticoagulation;Avidity;Binding;Biochemical;Blood;Blood Platelets;Circulation;Coagulation Process;Complex;Complication;Cryoelectron Microscopy;Death Rate;Development;Devices;enhancing factor;Environment;Exposure to;Extracorporeal Membrane Oxygenation;Fibrin;Fibrinogen;Fibrinolytic Agents;Formalin;Foundations;Glycoproteins;Hemoglobin;Hemoglobin A;Hemoglobin concentration result;Hemolysis;Hemolysis Induction;Hemorrhage;Hemostatic Agents;Hemostatic function;Intervention;Investigation;Measures;mechanical circulatory support;Mediating;Molecular;Molecular Conformation;Monitor;Mus;novel therapeutic intervention;Organ;Outcome;Pathology;Patients;Plasma;Process;Proteins;Publishing;Reaction;Recombinant Proteins;Reporting;Risk;Risk Factors;Role;shear stress;Surface;surface coating;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thrombosis;thrombotic;thrombotic complications;Thrombus;Variant;ventricular assist device;Visualization;von Willebrand Disease;von Willebrand Factor;von Willebrand factor receptor;Whole Blood;Work

PROJECT_TITLE: Molecular Studies of Hemolytic Thrombosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: The Translational Biophotonics + Additive Manufacturing conference is a meeting to allow effective interaction of Clinicians, Academics and Industry toward effective technology translation to clinical practice.

PI_NAMEs: TKACZYK, TOMASZ S (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Translational BioPhotonics/Additive Manufacuring for Biophotonics

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (O1)]