NIH_SPENDING_CATS: Autoimmune Disease;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Many patients with type 1 diabetes also experience obesity, increasing the risk of future cardiovascular disease. Semaglutide is an anti-obesity medication that improves cardiometabolic risk factors in individuals with type 2 diabetes and obesity. This proposal aims to understand how treatment with semaglutide impacts cardiometabolic risk factors and the driving mechanisms of these risk factors in young people with both type 1 diabetes and obesity.

PI_NAMEs: VAN NAME, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Abdomen;Acetyl Coenzyme A;Adipose tissue;Adolescent;Adolescent and Young Adult;adult obesity;Affect;aged;Agonist;analog;Apolipoproteins C;Automobile Driving;beta-Hydroxybutyrate;Biological Markers;Body Composition;Body fat;Body mass index;Body measure procedure;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Categories;Circulation;Clinic;Clinical;Clinical Trials;Closure by clamp;comparison group;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;Data;Diabetes Mellitus;disorder risk;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Dyslipidemias;Enrollment;euglycemia;Event;experience;Fatty acid glycerol esters;Fatty Liver;Future;glucagon-like peptide;glucagon-like peptide 1;Gluconeogenesis;Glucose;Glucose Clamp;glucose production;Glycerol;Glycosylated hemoglobin A;Health;Hepatic;hepatic gluconeogenesis;Hyperinsulinism;impaired glucose tolerance;improved;inclusion criteria;Individual;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Isotopes;lean body mass;Lipids;Lipolysis;Lipoproteins;Magnetic Resonance Imaging;Measures;Mediator;meetings;Metabolic;metabolic abnormality assessment;Metabolic syndrome;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;obesity treatment;Oral;Outcome;Overweight;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Placebos;Population;Prediabetes syndrome;Predisposition;Prevalence;Production;programs;Quality of life;Randomized;Research;Risk;Risk Factors;Scanning;stable isotope;subcutaneous;Surrogate Markers;Testing;Tracer;Triglycerides;Visceral;Visceral fat;Weaning;young adult;Youth

PROJECT_TITLE: Obesity complicating type 1 diabetes in young people: Physiology and Impact of GLP-1 analogue anti-obesity treatment on cardiometabolic risk factors

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Understanding of Hox gene regulation, a central developmental regulatory circuit, through the design, build and delivery of very large engineered variants of the Hox gene cluster is the focus of the proposal. The HoxA cluster controls normal development and is implicated in oncogenesis, and thus this work will enhance understanding and potential engineering of normal development and disease.

PI_NAMEs: MAZZONI, ESTEBAN ORLANDO (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 20 year old;Achievement;Address;Alleles;Animals;Anterior;Behavior;Bilateral;Binding;Binding Sites;Biological Process;Biology;Boundary Elements;Carpet;Cell Lineage;Cells;ChIP-seq;Chromatin;Code;Complement;Complex;Computers;cost;CRISPR/Cas technology;Data;Defect;design;Development;differentiation in vitro;Disease;Distal;DNA;Elements;Embryo;embryonic stem cell;Engineering;Epigenetic Process;experimental study;Gene Cluster;Gene Expression;Gene Expression Regulation;Gene Structure;Genes;Genetic;Genetic Transcription;genetic variant;Genome;Genomic approach;genomic locus;Genomics;Homeobox Genes;Human;in vivo;Knock-out;Light;Location;Logic;Methods;Modeling;Motor Neurons;Mouse Embryonic Stem Cells;Mus;mutant;Mutate;Neighborhoods;Neuronal Differentiation;novel;Output;Pattern;Phenotype;Rattus;Regulation;Regulatory Element;Rodent;Signal Transduction;Site;synthetic construct;System;Technology;Testing;TFRC gene;tool;transcription factor;Transcriptional Regulation;tumorigenesis;Variant;Work;Writing;Yeasts

PROJECT_TITLE: Synthetic HoxA to dissect transcriptional regulatory logic - TRFR

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Phosphatidic acid is a lipid signaling molecule whose aberrant production or accumulation can lead to many diseases, including several types of cancer, neurodegeneration, and susceptibility to infection. This proposal seeks to develop and apply cutting-edge toolsets to understand how cells regulate the production and metabolism of phosphatidic acid to maintain physiological processes that depend on it without tipping the balance away from homeostasis to favor pathological outcomes.

PI_NAMEs: BASKIN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acyl Coenzyme A;Agonist;Binding;Binding Proteins;Bioinformatics;Biology;Biotinylation;cancer type;Cell membrane;Cells;Cullin Proteins;Cytosol;Data;Directed Molecular Evolution;Disease;Dwarfism;Enzymes;Equilibrium;Event;Exhibits;feeding;Fishes;Generations;Goals;Head;Heritability;Homeostasis;Hydrolysis;improved;In Vitro;Infection;Lecithin;Light;Lipid Binding;lipid transfer protein;lipid transport;lipidome;Lipids;Location;Malignant Neoplasms;Mediating;Membrane;Metabolism;method development;Molecular;Molecular Conformation;Musculoskeletal Diseases;Mutation;Nerve Degeneration;next generation;Noise;optogenetics;Organelles;OS4 Gene;Outcome;Oxygen;Pathologic;Peptides;Peripheral;Phosphatidic Acid;Phosphatidylinositols;Phospholipase D;Phospholipids;Physiological;Physiological Processes;Predisposition;Production;Proteins;Proteome;Proteomics;recruit;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;spatiotemporal;Sterols;Syndrome;Time;tool;Toxic effect;ubiquitin-protein ligase;Ubiquitination;voltage

PROJECT_TITLE: Deciphering phosphatidic acid homeostasis and signaling using optogenetic membrane editors

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Because disorders of hunger cause obesity and feeding disorders, it is unfortunate that the neurobiological basis for hunger is so poorly understood. This proposal, by studying the neural activity of hunger-causing AgRP neurons, is discovering previously unknown, feedforward mechanisms by which AgRP neuron activity, and hence hunger, is increased. Uncovering the basis for and function of this feedforward activation of AgRP neurons should provide important new insights in how the motivational drive, hunger, is created.

PI_NAMEs: LOWELL, BRADFORD B (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TITLE: Feedforward Activation of AgRP Neurons and Hunger

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative  This proposal gathers cases of brain hemorrhage from around the world to identify the genetic factors that either cause or protect people from brain hemorrhage. The larger the sample size, the greater the power of the study and the investigators plan to increase the analysis from the current largest of roughly 1,500 cases to over 20,000 cases of brain hemorrhage. Specific ethnic groups may be particularly susceptible to brain hemorrhage and our study focuses on these important differences by ethnicity.

PI_NAMEs: ANDERSON, CHRISTOPHER DAVID;DEMEL, STACIE  (contact);WOO, DANIEL

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;adjudication;Adult;Affect;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Asian population;Atrophic;Basement membrane;biobank;Biological;Biological Process;Black Populations;Blinded;Brain hemorrhage;Cause of Death;Cell Proliferation;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Cerebrovascular Disorders;China;Clinical;clinical application;clinical care;clinical risk;cohort;Collaborations;Committee Members;cost effective;Data;Data Set;data sharing;Dementia;design;disability;disabled;Disease;disease phenotype;Endothelial Cells;Ensure;ethnic difference;ethnic diversity;Ethnic Origin;Ethnic Population;Exclusion;Funding;Future;Genetic;genetic association;genetic predictors;Genetic Risk;genetic risk assessment;genetic risk factor;genetic variant;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Genotype;Hematoma;Hemorrhage;Heterogeneity;Hispanic;Hispanic Populations;Hypertension;hypertension control;Image;improved;Incidence;Individual;innovation;insight;International;Intervention;intraventricular hemorrhage;Japan;Knowledge Portal;Leukoaraiosis;Life;Lobar;Location;Maintenance;Mental Depression;Meta-Analysis;multi-ethnic;Multiple Sclerosis;National Institute of Neurological Disorders and Stroke;neuroimaging;Neurologic;novel;online resource;Outcome;outcome prediction;Parkinson Disease;patient population;patient stratification;Patients;Persons;Phenotype;Philosophy;polygenic risk score;Population;predictive test;predictive tools;Predisposition;Prevention strategy;Principal Investigator;prognostic;prognostication;Publications;Publishing;Race;radiological imaging;recruit;Research Design;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;risk stratification;Role;Sample Size;Sampling;sex;sex variable;sharing platform;Site;Stroke;study population;Survivors;Syndrome;therapeutic development;tool;United States;United States National Institutes of Health;Variant;Vascular Dementia;White Matter Hyperintensity;whole genome;Women's Health

PROJECT_TITLE: ERICH-GENE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE A more diverse and inclusive scientific workforce is a strategy for ensuring that all Americans have access to high-quality, equitable, and effective health care. The proposed INSPIRE-US program aims to ameliorate social forces that have stifled the representation of racial minorities in the clinical and translational science workforce. This evidence informed program leverages best-practices known to promote career interest, research skill development, and the socioemotional support needed for undergraduates who identify as racial minorities to successfully join the clinical and translational science workforce.

PI_NAMEs: HICKMAN, RONALD LEE (contact);THORNTON, JOHN DARYL

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Address;American;Area;Attention;Behavioral;career;career awareness;Career Choice;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Cognitive;cohort;community building;community college;Competence;Credentialing;Education;education research;Educational Activities;Educational Curriculum;Emotional;Ensure;Equity;experience;Faculty;Fostering;hands on research;Health;health equity;Healthcare;Historically Black Colleges and Universities;Individual;Institution;Instruction;Intention;interest;Investments;Knowledge;Leadership;Learning;Long-Term Effects;Mentors;Mentorship;minority undergraduate;Mission;Motivation;next generation;Ohio;Participant;Persons;Population;Production;Program Development;programs;racial minority;recruit;Reproducibility;Research;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;skill acquisition;social;Social support;summer research;Talents;theories;Translational Research;translational scientist;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Workforce Development

PROJECT_TITLE: Clinical and Translational Science Collaborative of Northern Ohio, An Intensive Summer Education Program in Translational Research for Underrepresented Students (INSPIRE-US)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research seeks to improve the ability to observe interactions between biological molecules through the development of novel chemical tools. Success would increase our knowledge of cell biology, leading to an improved understanding of human disease and possible therapeutic interventions.

PI_NAMEs: DEVARAJ, NEAL KRISHNA (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Illuminating cellular dark matter through the development of novel chemical tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: About one fourth of women in the United States experience vaginal dysbiosis, a microbial composition lacking health-associated bacteria Lactobacillus and characterized by an increased susceptibility to vaginal infection. This proposal aims to reveal how a woman’s vaginal microbiome could naturally transition into dysbiosis and influence the immune system’s capacity to control infection. Specifically, we aim to define components of the vaginal microbiota that confer protection, thus providing tools for the development of prophylactic and therapeutic treatments.

PI_NAMEs: MEJIA, MARLYD ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Aerobic;Antibiotics;Bacteria;Bacterial Vaginosis;Basic Science;Bioreactors;career;Caring;Categories;Cells;Clinical;Clinical Research;Clinical Sciences;college;Communities;Dedications;Diagnosis;Disease;disorder risk;dysbiosis;Environmental Risk Factor;Estrus;Exhibits;experience;Female;Flow Cytometry;Genitourinary system;Gnotobiotic;Goals;gut microbiota;Health;Homeostasis;Human;Immune;immune cell infiltrate;immune function;immune resistance;Immune response;Immune system;Immunity;Immunologic Factors;Immunologics;improved;In Vitro;in vitro Model;in vivo;Incidence;Infection;Infection Control;Inflammatory Response;Institution;Integration Host Factors;Investigation;Knowledge;Lactobacillus;Mediating;Mediation;Medicine;Mentorship;Microbe;microbial;microbial community;microbial composition;microbial signature;microbiota;microorganism;Modeling;mouse model;Mus;neonate;neutrophil;Observational Study;Organ;pathobiont;pathogen;permissiveness;Play;Population;Population Heterogeneity;Predisposition;pregnant;prevent;Prevotella;Process;Property;prophylactic;Recurrence;recurrent infection;Regimen;reproductive;Research;research facility;Resistance;response;Ribosomal DNA;Role;Sampling;Science;Shapes;Site;Source;Streptococcus Group B;Swab;Symptoms;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissues;tool development;Training;Underrepresented Populations;United States;Vagina;vaginal infection;vaginal microbiome;vaginal microbiota;Vaginitis;Woman;Women's Health

PROJECT_TITLE: Determining the role of the vaginal microbiota in microbial and immunological resistance to vaginal pathobiont colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This multi-site randomized controlled trial (RCT) is among the first to test the efficacy of a behavioral intervention for achieiving durable increases in prevention effective pre-exposure prophylaxis (PrEP) adherence among stimulant-using men who have sex with men (MSM). Smartphone-based contingency management for directly observed PrEP doses is a potentially scalable intervention platform that will be augmented by a brief, evidence-based ARTEMIS positive affect intervention. Findings from this RCT will inform the targeted deployment of limited public health funding to reduce HIV incidence in this marginalized, underserved population of stimulant-using MSM that is a high priority for novel HIV prevention interventions.

PI_NAMEs: CARRICO, ADAM WAYNE (contact);JOHNSON, MALLORY O

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Abstinence;Adherence;Affect;AIDS prevention;Area;Attention;attentional control;Behavior Therapy;Behavioral;Blood;Caring;Cellular Phone;Chronic stress;Clinical;Clinical Research;Clinical Services;Cocaine;condomless anal sex;contingency management;Coping Skills;Crack Cocaine;craving;Diphosphates;Dose;Dryness;Effectiveness;efficacy testing;Epidemic;evidence base;Evidence based intervention;Exclusion Criteria;financial incentive;Florida;follow up assessment;Funding;Geographic Locations;Goals;gratitude;Happiness;Health behavior change;Health Benefit;Health Resources;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Human immunodeficiency virus test;improved;Incentives;Incidence;inclusion criteria;Individual;Intervention;intervention effect;marginalization;Measures;Mediator;men who have sex with men;Methamphetamine;methamphetamine use;Modeling;Newly Diagnosed;novel;novel strategies;open label;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;Population;Population Decreases;pre-exposure prophylaxis;prevent;Prevention;preventive intervention;primary outcome;Protocols documentation;psychologic;Psychological adjustment;Public Health;Randomized;Randomized, Controlled Trials;recruit;Regulation;Reporting;Research;Rewards;Risk;risk mitigation;Running;San Francisco;secondary outcome;sexual minority men;Site;Social Network;Specimen;Spottings;Stimulant;stimulant use;stimulant withdrawal;Stress and Coping;substance use;Substance Use Disorder;success;systematic review;Technology;Tenofovir;Testing;theories;Underserved Population;United States National Institutes of Health;Viral Load result;Visit;Work

PROJECT_TITLE: Optimizing PrEP adherence in sexual minority men who use stimulants


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Atypical sensitivity to sensory stimuli is a hallmark of multiple disorders including autism, schizophrenia, fragile X and others. We propose to use a simple well-defined model with conserved signaling pathways to understand how disease-associated genes like neurexin and neuroligin affect brain function. We aim to use our model to develop new early diagnostic tools and identify new targets for therapeutic intervention in these diseases.

PI_NAMEs: CHALASANI, SREEKANTH H. (contact);HART, MICHAEL P;PIERCE, JONATHAN THOMAS

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Animal Behavior;Animal Feed;animal old age;Animals;Attenuated;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Biological Assay;Brain;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Cells;Complex;cytomatrix;Diagnosis;diagnostic tool;Disease;Dyes;Food;Fragile X Syndrome;Functional Imaging;gastrointestinal;Gene Modified;Genes;Genetic;Genetic Polymorphism;Genetic Variation;Genome;genome wide association study;glutamatergic signaling;Glutamates;Homologous Gene;Homologous Protein;Human;Image;imaging modality;individuals with autism spectrum disorder;insight;intestinal barrier;Intestines;Life Cycle Stages;Link;loss of function;Maps;Measures;Mediating;Methods;Modeling;Molecular Probes;multisensory;mutant;Nematoda;Nervous System;neural circuit;neuromechanism;Neurons;Neuropeptides;neurotransmission;new therapeutic target;Pathway interactions;Patients;Peptide Signal Sequences;Phenotype;Physiological;Physiology;postsynaptic;presynaptic;Process;Quantitative Trait Loci;Resolution;risk variant;Role;Schizophrenia;Sensory;sensory stimulus;Signal Pathway;Signal Transduction;Signaling Molecule;social;Social Behavior;Stains;Structure;Synapses;Testing;Therapeutic Intervention;tool;transcriptome;uptake;Variant;whole genome

PROJECT_TITLE: Dissecting neural mechanisms integrating multiple inputs in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Nutrition;Obesity;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Despite several ground-breaking advances in the treatment of lung cancer, the overall outlook remains dismal, necessitating the urgent development of preventive therapies. We have observed that use of the anti-diabetic drug metformin is associated with improved lung cancer outcomes selectively in patients who are overweight and obese and have linked this association to metformin-induced immunological changes in both humans and mice. With a clinical trial and mouse experiments, we propose to study if the anti-cancer immune effect of metformin occurs in obese subjects who have a high risk for developing lung cancer occurs so that the drug may be used for cancer prevention.

PI_NAMEs: BARBI, JOSEPH ;REID, MARY E;YENDAMURI, SAIKRISHNA  (contact)

PROGRAM_OFFICER_NAME: SZABO, EVA

PROJECT_TERMS: Abate;Adenocarcinoma;Age;anti-cancer;Anti-diabetic Drugs;antitumor effect;Biological Response Modifiers;Biopsy;Blood;Body mass index;Bronchoalveolar Lavage;cancer diagnosis;Cancer Etiology;Cancer Model;cancer prevention;cancer risk;carcinogenesis;Cells;Chemoprevention;Chemopreventive Agent;cigarette smoking;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Color;cytokine;Cytometry;Development;Diabetes Mellitus;Disease;Disease Progression;disorder risk;Division of Cancer Prevention;Environment;Enzyme-Linked Immunosorbent Assay;Evaluable Disease;Event;experimental study;Flow Cytometry;former smoker;Gene Expression;Gene Expression Profile;high body mass index;high dimensionality;high risk;High-Risk Cancer;Human;human subject;Immune;Immune response;Immunologic Surveillance;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;Individual;Institution;Investigation;KRASG12D;Link;Lung;lung cancer prevention;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Metformin;Modeling;Molecular;mortality;mouse model;Mus;Mutation;Non obese;non-diabetic;Non-Small-Cell Lung Carcinoma;non-smoker;novel;obese patients;obese person;Obesity;Oral;Outcome;Overweight;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;phase II trial;Play;Population;Populations at Risk;Predisposition;prevent;Preventive;Preventive therapy;primary endpoint;programmed cell death protein 1;programs;protocol development;Randomized;randomized trial;Recording of previous events;Records;Regulatory T-Lymphocyte;Research Personnel;Risk Reduction;Sampling;Serum;Site;Squamous cell carcinoma;Survival Rate;T-Cell Activation;targeted treatment;Testing;Therapeutic;Tissues;tobacco smokers;Tobacco-Associated Carcinogen;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumor-immune system interactions;waist circumference

PROJECT_TITLE: Metformin for chemoprevention of lung cancer in obese subjects at high risk

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

PHR: PROJECT NARRATIVE Structured RNA elements are critical for regulating eukaryotic gene expression by diverse mechanisms, including at the level of translation. We are studying several examples of structured viral RNA elements that interact directly with the cell’s protein synthesis machinery and alter its function. Our goal is to uncover fundamental rules governing control of translation by RNA structure.

PI_NAMEs: KIEFT, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Binding;Binding Sites;Biochemistry;Bioinformatics;Biological;Cells;Complex;Coupled;Elements;Eukaryotic Cell;Gene Expression;Goals;insight;Internal Ribosome Entry Site;Link;Modeling;Nature;novel;Open Reading Frames;Play;Process;Protein Biosynthesis;Proteins;Ribosomes;RNA;RNA Sequences;Role;Structure;System;Transfer RNA;Translations;Viral;viral RNA;Work

PROJECT_TITLE: Structure, function, and dynamics of viral RNAs and RNA-containing complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative / Relevance We propose to extend IMP, an open source computer program for determining the structures of macromolecular machines based on varied data from multiple experimental methods. The resulting structures will allow us to better understand the workings of the cell, both under normal and disease conditions.

PI_NAMEs: SALI, ANDREJ  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 26S proteasome;Address;Algorithms;Archives;Benchmarking;Biological;biological systems;CCL21 gene;Cells;Chemicals;Chimera organism;Collaborations;Communities;Complex;computer program;Computer software;Computing Methodologies;crosslink;Cysteine;Data;data repository;Data Sources;Databases;density;Deposition;design;Deuterium;Development;Disease;Documentation;Educational workshop;Electron Microscopy;flexibility;Fluorescence Resonance Energy Transfer;Foundations;Funding;Goals;Hybrids;Hydrogen;improved;insight;kinematics;Knowledge;Letters;Licensing;Literature;macromolecular assembly;Maps;Mass Spectrum Analysis;Membrane Transport Proteins;Methods;Modeling;Molecular Conformation;Molecular Structure;mutant;Nuclear Pore Complex;open source;pathogen;Productivity;programs;protein data bank;Proteins;Proteomics;Protocols documentation;PrP;repository;Research Project Grants;Resolution;Resources;restraint;Roentgen Rays;Sampling;Scheme;Shapes;spindle pole body;Structural Models;Structure;System;Testing;tool;Trees;Uncertainty;Variant;Vertebral column;Work;X-Ray Crystallography

PROJECT_TITLE: IMP: Software for Hybrid Determination of Macromolecular Assembly Structures

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Contraception/Reproduction;Genetics;Human Genome;Infertility;Intellectual and Developmental Disabilities (IDD);Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to build a model of the human ovary using stem cells. The stem cells will be differentiated using transcription factors to create ovarian granulosa cells and germline cells, which together make up ovarian follicles. This would enable important advances in the study of female reproduction, potentially leading to new treatments for infertility and better understanding of developmental disorders.

PI_NAMEs: PIERSON SMELA, MERRICK DE FOREST (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: American;Angelman Syndrome;Area;Biological Models;bisulfite sequencing;Cell Differentiation process;Cell Line;cell motility;Cell Physiology;Cell Reprogramming;cell type;Cells;Characteristics;ChIP-seq;Chromosome abnormality;Church;Coculture Techniques;combinatorial;computerized tools;Development;developmental disease;Developmental Process;differentiation protocol;directed differentiation;Disease;DNA methyltransferase inhibition;Down's Syndrome;Embryonic Development;Engineering;Epigenetic Process;epigenetic profiling;epigenome;Estradiol;experimental study;extracellular;Female;Female infertility;Fertility;fetal;Fetus;FOXL2 gene;Gene Expression Profiling;Generations;Genetic;Genetic Transcription;Germ Cells;Germ Lines;Goals;granulosa cell;Growth;Growth Factor;Human;Human Development;human induced pluripotent stem cells;human model;Impairment;improved;In Vitro;in vitro Model;induced pluripotent stem cell;infertility treatment;insight;interest;Knock-out;Meiosis;Methods;Modeling;Mouse Embryonic Stem Cells;mouse model;Mus;Oocytes;Oogenesis;Oogonia;Organism;Organoids;Ovarian;Ovarian Follicle;Ovarian Granulosa Cell;Ovary;Paracrine Communication;Phenotype;pluripotent stem cell differentiation;Prevention;Process;Production;Publishing;reconstitution;Regulation;Reporter;Repression;Reproduction;reproductive;reproductive development;Research;response;Route;screening;sex development disorder;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Somatic Cell;Specific qualifier value;stem cells;Structure;Structure of primordial sex cell;System;Techniques;transcription factor;transcriptomics;Transgenic Organisms;transmission process;Validation;Woman;Women's study

PROJECT_TITLE: Human iPSC-derived ovarian follicles as a model of female reproduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Continuous glucose monitors (CGM) improve glycemic control, health related quality of life and treatment satisfaction in individuals with type 1 diabetes, and are recommended as standard of care practice in both children and adults with type 1 diabetes. Despite these benefits, CGMs are underutilized, particularly among minorities and individuals from underserved communities. In this proposal, we aim to develop the role and toolkit of a diabetes navigator, who will be implemented in the real-world clinical setting to help increase CGM uptake and sustained CGM use, as a means to improve glycemic control and mitigate disparities in care and outcomes across the lifespan for underserved individuals with type 1 diabetes.

PI_NAMEs: MATHIOUDAKIS, NESTORAS N;WOLF, RISA MICHELLE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adoption;Adult;Affect;American;arm;Blood Glucose;Caring;Child;Childhood;Childhood diabetes;Chronic Disease;Clinical;Clinical Trials;Communities;community partners;Complications of Diabetes Mellitus;Continuous Glucose Monitor;cost;Data;Devices;Diabetes Mellitus;Disparity;disparity reduction;Education;emerging adult;Ensure;evidence base;experience;Feasibility Studies;Feedback;follow-up;Future;glycemic control;Glycosylated hemoglobin A;Goals;Habits;health care disparity;health related quality of life;Hybrids;improved;Individual;Infrastructure;Injections;innovation;Institution;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Insurance;Insurance Coverage;Intervention;Interview;Knowledge;Life;life span;Minority;minority children;Minority Groups;Modeling;multidisciplinary;novel;Outcome;outcome disparities;Participant;Patient Care;Patient Outcomes Assessments;Patients;Pediatrics;Phase;Pilot Projects;point of care;Population;preference;prevent;Provider;Pump;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Request for Applications;response;Role;satisfaction;Shapes;standard of care;Standardization;success;System;Technology;treatment arm;trial comparing;Underrepresented Populations;underserved community;Underserved Population;uptake;Youth

PROJECT_TITLE: Implementation of a diabetes navIgator to Mitigate disPArities and improve CGM upTake and sustained use across the lifespan of T1D (IMPACT T1D)


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Cryo-EM data processing for structural biology improves and accelerates drug discovery that treats diseases and is driving innovation, economic growth, and happening in the pharma industry. Our proposed continuing education program aims to develop a portable continuing education solution with integrated data, software, workflow, and a sustainable computing environment that trains diverse cohorts of structural biology investigators to strengthen their Cryo-EM data processing skills, as well as enables them with a training solution that they could adapt and use in continuing education programs in Cryo-EM data processing at their home institution or local community. This enhanced research training program will have the potential to provide and scale sustainable continuing education in Cryo-EM data processing to a diverse group of individuals for a biomedical career of the future.

PI_NAMEs: DAVIS, JAMAINE S;SLIZ, PIOTR  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: academic program;Acceleration;Address;American;Automobile Driving;Biomedical Research;Boston;career;cohort;Collection;Communities;Computational Technique;Computer software;computerized data processing;computerized tools;computing resources;Continuing Education;cost;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Analyses;data exchange;data integration;Data Science;Data Set;data visualization;deep learning;design;Disease;Documentation;drug discovery;Economics;Environment;evidence base;Faculty;Future;Growth;High Performance Computing;Historically Black Colleges and Universities;Home;improved;Individual;Industry;Infrastructure;innovation;Institution;Knowledge;Knowledge acquisition;Laboratories;Leadership;Marketing;Measures;medical schools;member;Mentors;Minority-Serving Institution;Modeling;molecular modeling;next generation;novel;online community;Outcome;Participant;peer;peer coaching;Persons;Phase;portability;Principal Investigator;process optimization;Productivity;programs;Reporting;Research;Research Personnel;Research Training;Resources;Series;skill acquisition;skills;Societies;Structural Biologist;structural biology;Structure;Students;support network;Surveys;System;Techniques;tomography;tool;Training;Training Activity;training data;Training Programs;Travel;undergraduate student;Underrepresented Minority;Universities;Visualization software;X-Ray Crystallography

PROJECT_TITLE: Continuing Education for Structural Biology Mentors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Trisomy 21 is thought to broadly impact the development, transcriptome, and activity of many neural cell types. However, the extent to which DS alters each is conflicted and potentially overestimated by variability not due to trisomy. Reducing variability through “trisomy silencing” will increase the power to detect legitimate effects of trisomy 21 in different neural cell types, when during development changes occur, and which remain correctable.

PI_NAMEs: LARSEN, ERIC CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Amyloid beta-Protein;Autopsy;Biology;Brain;brain cell;Brain region;Cell Cycle;Cell Line;cell type;Cells;Chromosome 21;Cognitive deficits;Complex;Data;Development;Disease;disease phenotype;dosage;Dosage Compensation (Genetics);Down's Syndrome;Early Onset Alzheimer Disease;Epigenetic Process;excitatory neuron;experimental study;Gene Dosage;Gene Silencing;Genes;Genetic;Genetic Transcription;genome-wide;Human;human induced pluripotent stem cells;Impaired cognition;Impairment;In Vitro;induced pluripotent stem cell;innovation;insight;Intellectual functioning disability;Investigation;Length;Mediating;Methods;Modeling;monolayer;mouse model;nerve stem cell;neural;neurodevelopment;neurodevelopmental effect;neurogenesis;Neuronal Differentiation;Neurons;neuropathology;Organoids;overexpression;Pathology;Pathway Analysis;Pathway interactions;Phenotype;Population;prevent;Publishing;Reporting;Repression;Research;Role;Sampling;Sorting;stem cell fate;stem cell proliferation;Study models;System;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;transgene expression;Transgenes;Transgenic Organisms;Trisomy;Variant;Work

PROJECT_TITLE: Investigating Trisomy 21 Impact on Human Neural Cell Development and Function Using "Trisomy Silencing" in vitro


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative There are currently no clinical biomarker tests available to assess risk of recurrence in women diagnosed with triple negative breast cancer or HER2+ breast cancer. The goal of this study is to validate an assay that measures expression of genes associated good prognosis. If successful, this could be the first clinical test available to guide therapy decisions based on risk of recurrence in triple negative breast cancer and HER2+ breast cancer patients.

PI_NAMEs: BERNARD, PHILIP S;VARLEY, KATHERINE ELENA (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adjuvant Study;Antigen Presentation Pathway;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Breast Cancer Patient;chemotherapy;Chemotherapy-Oncologic Procedure;CLIA certified;clinical biomarkers;clinical development;Clinical Trials;cohort;Data;Diagnostic;Disease-Free Survival;Enrollment;Ensure;ERBB2 gene;Estrogen receptor positive;Excision;Exclusion;experience;Formalin;Future;Gene Expression;Gene Expression Profiling;Goals;Health Care Costs;High Prevalence;Histocompatibility Antigens Class II;immune activation;improved;In complete remission;Institution;International;Laboratories;Leucocytic infiltrate;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Modernization;Mus;National Cancer Institute of Canada;Neoadjuvant Therapy;Oncologist;Operative Surgical Procedures;Paclitaxel;Paraffin Embedding;participant enrollment;Pathologic;Patient Care;patient prognosis;Patient-Focused Outcomes;Patients;Phase;Prognosis;prognostic;Prognostic Factor;Quality of life;Randomized, Controlled Trials;Recurrence;Recurrent disease;Reporting;research clinical testing;Residual Neoplasm;Risk;Risk Assessment;Sampling;side effect;Specificity;Specimen;Testing;Treatment Protocols;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;Validation;Woman;women's diagnosis

PROJECT_TITLE: Validation of the MHC II Immune Activation Assay in Breast Cancer


NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Uterine Cancer;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The human and mouse endometrium can respond to acute or chronic injuries with scar-free regeneration. This application proposes an integrative set of studies that will define critical physiological and genetic pathways that regulate the remarkable regenerative capacity of the uterine epithelium upon injury. The results will significantly increase our understanding of endometrial epithelial differentiation and regeneration with subsequent impacts to diagnose, treat, and prevent infertility and endometrial disease in women.

PI_NAMEs: KELLEHER, ANDREW M (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Adult;Asherman Syndrome;Behavior;Biological;Biological Assay;Biology;Bone Marrow;Cell Differentiation process;Cell Physiology;cell regeneration;cell type;Cells;Childbirth;Chromatin;Chronic;Cicatrix;Complex;Data;Defect;Development;Diagnosis;differentiation in vitro;Disease;Distant;Endometrial;Endometrial Carcinoma;endometrial organoid;endometriosis;Endometrium;Ensure;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Event;Fibroid Tumor;Genes;Genetic;Genetic Models;Genetic Transcription;Goals;Hematopoietic stem cells;Homeostasis;Human;Human body;Immune;In Vitro;in vivo;Infertility;Injury;injury and repair;innovation;Knowledge;life span;Location;Menstruation;Messenger RNA;Molecular;Molecular Profiling;mouse genetics;multiple omics;Mus;Natural regeneration;novel;Organ;Organoids;Outcome;Pathway interactions;Pericytes;Periodicity;Phylogenetic Analysis;Physiological;Population;population based;Pregnancy;Pregnancy Maintenance;prevent;Process;Proliferating;recruit;regenerative;Regenerative capacity;Regenerative Medicine;Regenerative response;repaired;Reporter;Reporting;Research;response;Role;screening;single cell sequencing;stem;stem cell biology;stem cell model;stem cell population;stem cells;stemness;Stromal Cells;success;System;Technology;Testing;therapeutic development;Tissue Engineering;tissue regeneration;tissue repair;Tissues;transcription factor;Uterus;Woman

PROJECT_TITLE: Mechanisms Governing Uterine Epithelial Plasticity

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In this proposal we aim to understand the impact of PD-L1 reverse signaling by dendritic cells during an immune response to cutaneous infection. We will investigate consequences of PD-L1 reverse signaling to dendritic cell migration and subsequent T cell priming.

PI_NAMEs: TAMBURINI, BETH ANN (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Actins;adaptive immunity;Address;Alanine;Amino Acid Motifs;Amino Acids;anti-PD-L1;Antigens;Archives;Autoimmune;cancer cell;CCL21 gene;CD80 gene;Cell Communication;cell motility;cell type;Cells;chemokine;Cutaneous;Cytolysis;Cytoplasm;Cytoplasmic Tail;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Defect;Dendritic Cells;Dermal;Development;draining lymph node;Event;experience;extracellular;Extracellular Domain;Goals;Human;Immune;Immune response;Immunity;Immunization;improved;In Vitro;in vivo;Induction of Apoptosis;Infection;Infectious Skin Diseases;Inflammatory Response;Interferons;IRF1 gene;Listeriosis;lymph nodes;Lymphatic;Lymphatic Capillaries;Malignant Neoplasms;Memory;migration;Molecular;mouse model;Mus;Mutate;Mutation;novel;pathogen;polymerization;Polymers;programmed cell death ligand 1;programmed cell death protein 1;Publishing;Regulation;response;Role;Signal Transduction;Skin;Stimulus;Systemic infection;T cell response;T memory cell;T-Cell Proliferation;T-Lymphocyte;Therapeutic Intervention;Time;Tissues;trafficking;transcription factor;tumor progression;Vaccination;Vaccinia;Virus Diseases;XCR1 gene

PROJECT_TITLE: PD-L1 reverse signaling in dermal DCs promotes DC migration and skin immunity to cutaneous pathogens

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: AG

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative  Cognitive impairment associated with normative aging and with the early stages of Alzheimer's Disease and other dementias (ADOD) often result in loss of independent living, but few effective therapeutic strategies exist to predict, prevent, or treat it. Recent studies have suggested that altered neuroinflammatory signaling may play an important early role in normative aging, and in ADOD, but the mechanisms by which the complex interaction of pro- and anti-inflammatory pathways change over the lifespan, relate to changes in brain microstructure/morphology, or modulate cognition are unclear. The proposed research in this application will use state-of-the-art neuroscience technologies (CSF protein biomarker assays, PET imaging of activated microglia, MRI, NODDI, and cognitive assessment) in a naturally-occurring animal model of age- related cognitive impairment to identify early markers of neuroinflammation and neurodegeneration that are associated with age-related changes in brain morphology/microstructure and cognition.

PI_NAMEs: WEISS, ALISON RUTH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;aged;Aging;aging process;Alzheimer's Disease;American;Animal Model;animal old age;Animals;Anti-Inflammatory Agents;Area;Astrocytes;Atrophic;Behavior;Biological Assay;Biological Markers;biomarker identification;Biometry;Brain;brain morphology;Cells;cerebral atrophy;Cerebrospinal Fluid;clinically relevant;Cognition;cognitive testing;Complex;Corpus striatum structure;Data;Dementia;density;Diffusion;disease model;Early Diagnosis;Early identification;Exhibits;Foundations;Future;Gliosis;Goals;gray matter;healthy aging;histological studies;Human;Image;Impaired cognition;Independent Living;Inflammation;Inflammatory;Infrastructure;innovation;life span;long-term sequelae;Macaca;Macaca mulatta;Magnetic Resonance Imaging;mature animal;Measures;Mediating;Memory impairment;Microglia;microPET;middle age;minimally invasive;Modeling;Monkeys;Morbidity - disease rate;Morphology;morphometry;multimodal neuroimaging;multimodality;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurosciences;normal aging;novel;novel marker;pathological aging;Pathway interactions;Patients;Pattern;Play;Population;Positron-Emission Tomography;potential biomarker;Pre-Clinical Model;prevent;Process;Productivity;programs;Proliferating;protein biomarkers;Proteomics;Public Health;Refractory;Research;Research Technics;Resolution;Resources;Role;Sampling;Screening procedure;Sensitivity and Specificity;Short-Term Memory;Signal Transduction;Structure;Symptoms;Technology;Testing;Thalamic structure;Therapeutic;therapeutic target;therapeutically effective;Tissue Banks;white matter;Work;young adult

PROJECT_TITLE: Biomarkers of Inflammation, Neurodegeneration and Age-Associated Cognitive Impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: 8. Project Narrative A major feature of substance use disorders is compulsive drug use: habitual drug-seeking behavior that is rigid, inflexible, and often triggered by particular cues and contexts in the user’s environment. The experiments in this proposal will help us understand the brain mechanisms by which drug-seeking, like other forms of reward- seeking, can initially be “goal-directed” – i.e., driven by the pursuit of a desired outcome, such as euphoria or relief from withdrawal – and later become habitual. In particular, we will investigate how different parts of the amygdala, a brain area involved in forming associations between cues and rewards, are involved in the initial acquisition of reward seeking vs. the formation of habits.

PI_NAMEs: MORRISON, SARA  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acceleration;addiction;Advisory Committees;Amygdaloid structure;Area;Award;Behavior;Behavior Control;Brain;Brain region;cocaine self-administration;Communities;Corpus striatum structure;craving;Cues;Dedications;Designer Drugs;Development;Dissection;Dopamine;Dopamine Receptor;dopaminergic neuron;Dorsal;Drug abuse;Drug Exposure;drug of abuse;drug reward;drug seeking behavior;Drug usage;Electrophysiology (science);Environment;Environmental Risk Factor;Euphoria;experience;experimental study;flexibility;Food;Genetic;genetic approach;Goals;Grant;Habits;Halorhodopsins;Human;Individual;Maintenance;Medial;motivated behavior;neural;neural circuit;neuromechanism;Neurons;Neurosciences;neurotransmission;novel;Occupations;optogenetics;Outcome;Pharmaceutical Preparations;Positioning Attribute;Prefrontal Cortex;Process;Publishing;Rattus;receptor;Recreation;Research;Rewards;Role;satisfaction;selective expression;Self Administration;Signal Transduction;skills;Stress;Substance Addiction;substance use;Substance Use Disorder;Techniques;tenure track;Testing;theories;Time;Training;Universities;Ventral Striatum;Ventral Tegmental Area;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Neural Mechanisms of Habit Formation for Behaviors Motivated by Drugs of Abuse and Natural Reward

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Following weight loss, the new lower body weight is extremely difficult to maintain. Many studies have shown this is because individuals who lose a significant amount of body weight typically have a “Calorie Gap” post- weight loss, meaning that after weight loss, it requires fewer calories to maintain this new weight than it does for individuals at that same weight who never had obesity. A brain neurochemical, called orexin, drives calorie- burning. In this application, we will test whether peripheral administration of compounds mimicking orexin reverse this “calorie gap”, and thus prevent weight regain in animal models of obesity.

PI_NAMEs: KOTZ, CATHERINE M (contact);ZHANG, YANAN

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: absorption;abuse liability;Address;Affinity;Agonist;analog;Animal Model;Animals;Automobile Driving;Behavioral;Body Weight;Body Weight decreased;Brain;Caloric Restriction;Calories;Chronic;comorbidity;Compensation;Consumption;Data;design;diet-induced obesity;Drug Kinetics;Eating;Energy Metabolism;Evaluation;Excretory function;Exercise;exercise program;Expenditure;Fatty acid glycerol esters;Goals;Homeostasis;Human;hypocretin;Hypothalamic structure;improved;improvement on sleep;Indirect Calorimetry;Individual;Injections;interest;Laboratories;Left;Metabolic;Metabolism;middle age;Mitochondria;Modeling;Molecular;neurochemistry;Neurons;Neuropeptides;New Zealand;Obese Mice;Obesity;obesity treatment;old mice;orexin A;Overweight;Pattern;Peptides;Peripheral;Physical activity;Physical Exercise;Play;prevent;Property;Public Health;Rattus;receptor;Regulation;Relapse;Reporting;research and development;Respiration;Rodent Model;Role;side effect;Sleep;small molecule;Structure;Study models;Subconscious;System;Testing;Therapeutic;therapy development;total energy expenditure;Toxic effect;Wakefulness;Weight;Weight Gain

PROJECT_TITLE: Reducing the post weight-loss energy expenditure gap with orexin agonists


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The goal of this project is to test the effectiveness of a novel behavioral treatment for nondaily smokers; namely a smartphone app that engages app users in positive psychology exercises to bolster their positive affect as they undergo the process of quitting smoking. This app has been rigorously and iteratively developed with and for nondaily smokers. If found effective, it would be the first treatment for nondaily smokers found to be effective.

PI_NAMEs: HOEPPNER, BETTINA B. (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Abstinence;Acceleration;Address;Adult;Affect;Barrier Contraception;behavior test;Behavior Therapy;Behavioral;Black Populations;Cigarette;Clinical Practice Guideline;Collaborations;comparison control;Control Groups;craving;Data Collection;Effectiveness;effectiveness testing;efficacious treatment;efficacy testing;Enrollment;Exercise;Failure;Goals;Health;Health behavior;health disparity;improved;Intervention;Latinx population;meetings;Mental Health;Methods;Modeling;Motivation;National Cancer Institute;novel;Outcome;Outcome Measure;Participant;Pattern;Persons;pharmacologic;Pharmacological Treatment;preference;Prevalence;primary endpoint;primary outcome;Process;Psychology;Public Health;public health priorities;Race;randomized trial;randomized, clinical trials;Readiness;Reporting;Research;Self Efficacy;Series;Single-Blind Study;smartphone application;Smiling;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Surveys;Testing;theories;Therapeutic;therapy resistant;treatment duration;treatment guidelines;trial comparing;United States;Withdrawal;Work

PROJECT_TITLE: Randomized clinical trial to test the efficacy of a smartphone app for smoking cessation for nondaily smokers

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: Project Narrative Our proposal addresses a significant clinical problem of obesity-mediated worsening of asthma. By assembling a multidisciplinary team of scientists, we propose to study a new mechanism, mitochondrial dysfunction, in the pathogenesis of obese asthma, a heterogenous disease currently without specific therapies. Our research findings likely provide several key targets including Parkin and TLR9 to treat obese asthma.

PI_NAMEs: CHU, HONG W (contact);HOLGUIN, FERNANDO ;SEIBOLD, MAX A

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Adrenal Cortex Hormones;airway epithelium;airway inflammation;Allergens;antagonist;Arginine;Asthma;asthma exacerbation;asthmatic;asthmatic airway;Basic Science;Biological Availability;bronchial epithelium;Bronchoalveolar Lavage Fluid;CCL26 gene;Cell Culture Techniques;chemokine;Clinical;CRISPR/Cas technology;cytokine;Disease;eosinophil;eosinophilic inflammation;Eotaxin;Epithelial Cells;Equilibrium;experience;Exposure to;Gene Activation;Goals;High Fat Diet;Human;Inflammation;Inhalation;inhibitor;innovation;Interferon Type II;Interferons;Interleukin-13;interleukin-13 receptor;Knock-out;Liquid substance;Lung;Measures;Mediating;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mouse model;multidisciplinary;Mus;N,N-dimethylarginine;neutrophil;Neutrophil Infiltration;Nitric Oxide;Nitric Oxide Synthase;nitrosative stress;novel;Obesity;obesity-associated asthma;Palmitic Acids;Parkin;Pathogenesis;PINK1 gene;Production;Public Health;Reactive Oxygen Species;Research;Research Personnel;Respiration;response;Role;Sampling;Saturated Fatty Acids;Scientist;Serum;Signal Pathway;Signal Transduction;Slice;STAT1 gene;STAT6 gene;Stimulator of Interferon Genes;TBK1 gene;Testing;therapeutic evaluation;Thinness;Transcription Repressor;Translational Research;ubiquitin-protein ligase;Up-Regulation

PROJECT_TITLE: Parkin in mitochondrial dysfunction and airway inflammation of obese asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Latinos have a disproportionately higher risk of cardiometabolic disease, further compounded by disparities in socioeconomic status. Although the role of nutrition education and physical activity has been investigated, evidence on culturally-adapted multicomponent synergistic interventions in this population is lacking, especially interventions that consider Latino ethnic heritages. This proposal aims to evaluate the feasibility of a culturally- adapted Teaching Kitchen (TK) model program, a multicomponent synergistic intervention (nutrition education, culinary training, enhanced movement and exercise, mindfulness training, and health coaching) in a sample of Latinos of diverse ethnic heritages and low income to reduce cardiometabolic risk.

PI_NAMEs: PACHECO, LORENA SONIA (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Area;Attitude;Award;Behavior;Behavioral Sciences;Boston;California;Canada;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;career development;Central American;Certification;Clinical Trials;Cluster randomized trial;cohort;Communities;community based participatory research;community clinic;cooking;Cooking Practices;Counseling;Cuban;Data;Development Plans;Diet;dietary;Dietary intake;Dietary Intervention;Disparity;Doctor of Philosophy;Dominican;Eating;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Environment;Epidemiologist;ethnic diversity;Ethnic Origin;Evaluation;evidence base;Exercise;Family;Focus Groups;Food;food insecurity;food preparation;Foundations;Frequencies;frontier;Funding;Gender;Goals;good diet;Health;Health behavior;Health Sciences;healthy lifestyle;healthy weight;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Home;improved;Individual;innovation;Institution;Instruction;Internet;Intervention;intervention program;Interview;Island;Knowledge;Latino;Latino Population;Low income;Medical center;Medicine;Mentors;Mentorship;Metabolic syndrome;Methods;Mexican;Mexico;mindfulness;Mindfulness Training;minority communities;Minority Groups;Modeling;Movement;multi-component intervention;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;nutrition;nutrition education;Nutritional;Nutritional Science;Obesity;Participant;Phase;Physical activity;Population;Postdoctoral Fellow;preference;prevent;Prevention strategy;primary outcome;Process;programs;Public Health;Public Health Schools;Puerto Rican;Puerto Rico;Randomized;Readiness;Recommendation;recruit;Research;Research Activity;Research Personnel;Resources;retention rate;Risk;Risk Factors;Risk Reduction;Role;Rural;Sampling;secondary outcome;skills;Socioeconomic Status;South American;stress management;Structure;success;Surveys;symposium;therapy development;Training;Training Programs;treatment as usual;Variant;Work;Youth

PROJECT_TITLE: A Culturally-Adapted Multicomponent Teaching Kitchen Intervention for Low-Income Latino Adults


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

PHR: Project narrative The goal of this project is to engineer therapeutic immune cells that migrate to and accumulate in tumors, such that they can more effectively kill tumor cells. The resulting next-generation therapeutic immune cells could lead to much more effective therapies against a broad range of challenging solid tumors.

PI_NAMEs: EL-SAMAD, HANA ;LIM, WENDELL A (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Adhesions;Architecture;Behavior;Bilateral;Bone Marrow;cell motility;Cell Physiology;Cell-Cell Adhesion;Cells;Chemotaxis;chimeric antigen receptor T cells;combinatorial;Complex;Cytokine Signaling;design;Disease;effective therapy;engineered T cells;Engineering;Exclusion;exhaustion;experimental study;Goals;Hematopoietic Neoplasms;Home;Immune;immune cell infiltrate;Immunocompetent;Immunological Models;Immunologics;Immunotherapeutic agent;improved;in silico;In Vitro;in vivo;Infiltration;Libraries;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;mesothelin;migration;Modeling;mouse model;multi-scale modeling;Mus;neoplastic cell;novel therapeutics;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Performance;Predisposition;programs;Proliferating;receptor;Regulation;residence;response;Signal Transduction;single cell analysis;Solid;Solid Neoplasm;Spleen;success;Suppressor-Effector T-Lymphocytes;T cell infiltration;T cell therapy;T-Lymphocyte;Testing;Tissue Model;Tissues;trafficking;tumor;Tumor Antigens;Tumor Suppressor Proteins;tumor xenograft

PROJECT_TITLE: Synthetic circuits that drive infiltration of therapeutic T cells into immunologically cold tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Lung;Lung Cancer;Microbiome;Precision Medicine;Skin Cancer

PHR: Project Narrative One of the most intriguing findings in the field of cancer immunotherapy is the recent demonstration that the gut microbiome regulates immune and clinical antitumor responses to immune checkpoint blockade (ICB) in cancer patients. Here, we propose to identify whether a baseline beneficial and a detrimental gut microbiome predict clinical outcome and immune-related adverse events to ICB in cancer patients. We will also investigate whether fecal microbiota transplant convert ICB-refractory cancer patients into responders and impede the occurrence of serious adverse events.

PI_NAMEs: ZAROUR, HASSANE M (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: adaptive immune response;Address;Age;anti-CTLA4;anti-PD-1/PD-L1;anti-PD1 antibodies;Antitumor Response;Applications Grants;Bioinformatics;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Clinical;clinical center;Clinical Trials;cohort;Computer Analysis;Correlative Study;Diet;Engraftment;Exhibits;fecal transplantation;first-in-human;Funding;Funding Agency;Gene Expression Profile;Geographic Locations;gut microbiome;gut microbiota;Human;Human Papillomavirus;Immune;immune checkpoint blockade;immune-related adverse events;Immunologics;Immunosuppression;improved;Innate Immune Response;Intake;Lymphocyte;Malignant Neoplasms;Melanoma;Melanoma patient;metabolomics;microbial;microbiome;microbiome composition;microbiota;Monoclonal Antibodies;Multiomic Data;Mus;Mutation;Myelogenous;neutrophil;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Organism;Outcome;Pathway Analysis;Patients;Performance;Pharmaceutical Preparations;phase 2 study;Phase II Clinical Trials;predict clinical outcome;predictive marker;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Refractory;refractory cancer;Reporting;Research Proposals;Resistance;resistance mechanism;response;response biomarker;Role;Serious Adverse Event;Serum;sex;Site;Solid Neoplasm;systemic inflammatory response;T-Cell Activation;T-cell inflamed;Translational Research;Translations;tumor;tumor microenvironment;United States National Institutes of Health;Universities;Virus

PROJECT_TITLE: Therapy with fecal microbiota transplantation and immune checkpoint blockade for solid tumors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Diverse subtypes of retinal ganglion cells send parallel outputomes to retinorecipient regions, including the superior colliculus (tectum), an evolutionarily conserved midbrain structure, mediating visual evoked innate behaviors. We propose to map out parallel retinotectal circuits, understand cellular and molecular mechanisms regulating specific retinotectal circuit wiring, and link specific retinotectal circuits to defined visual evoked behaviors. Our studies will reveal wiring principles for synaptic convergence and divergence in the mammalian brain and provide significant insights into higher visual processing.

PI_NAMEs: DUAN, XIN  (contact);SCANZIANI, MASSIMO

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Animal Behavior;Area;Axon;axon growth;Behavior;Behavioral;Binding;Bioinformatics;Brain;Communication;Complex;Data;defense response;Development;Electrophysiology (science);empowerment;Engineering;Ensure;excitatory neuron;extracellular;Freezing;Future;ganglion cell;Genetic;genetic analysis;genetic manipulation;Glycoproteins;Goals;Histology;Image;Individual;inhibitory neuron;insight;Instinct;Integrins;Knowledge;Label;Lead;Link;Maps;Measurement;Mediating;Methods;Midbrain structure;Molecular;Motion;Mus;nephronectin;Nervous System Physiology;neural circuit;neuronal circuitry;Neurons;optogenetics;Output;Population;postsynaptic;postsynaptic neurons;Resolution;Retina;Retinal Ganglion Cells;retinotectal;Role;sequencing platform;single-cell RNA sequencing;Sorting;Specificity;superior colliculus Corpora quadrigemina;Synapses;System;Tectum Mesencephali;tool;Tracer;Visual;visual processing;Visual System;Wheat Germ Agglutinins;Work

PROJECT_TITLE: MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Vascular cognitive impairment is one of the most prevalent causes of age-related decline of brain health. Vascular changes precede neuronal alterations thus they provide targets for potential, new therapeutic approaches. Thermogenesis positively affects metabolism and systemic inflammation thus it can be used as a therapeutic option to boost cerebrovascular health and cognitive status.

PI_NAMEs: BALASUBRAMANIAN, PRIYA  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Adipocytes;adipokines;adiponectin;Adipose tissue;Adrenergic Agonists;Affect;age related;age related decline;age-related disease;aged;Aging;aging population;Alzheimer's disease related dementia;Angiography;Attenuated;Biological Assay;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain health;Brown Fat;Capillary Permeability;Caring;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;Chronic;Circulation;Cognition;Cognitive;cognitive performance;cost;Custom;Data;Data Science;density;design;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;Expenditure;experience;FGF21 gene;fibroblast growth factor 21;Functional disorder;Future;glucose metabolism;Health;Human;Impaired cognition;Impairment;improved;Incidence;Inflammation;inflammatory milieu;insulin sensitivity;Interdisciplinary Study;Intervention;Laser Speckle Imaging;Lead;Link;lipid metabolism;lipidomics;Lipids;Longevity;Mediating;Mediator;Mentored Research Scientist Development Award;Metabolic;Metabolic dysfunction;Metabolism;Modeling;neuroinflammation;Neurons;neurovascular;neurovascular coupling;Nitric Oxide;novel;novel strategies;novel therapeutic intervention;old mice;Optical Coherence Tomography;Outcome;Parabiosis;Pathologic;Pathway interactions;Persons;pharmacologic;Phenotype;Play;preservation;prevent;Prevention;Process;Production;programs;Rejuvenation;Reporting;Research;response;Role;Signal Transduction;skills;social;Structure;Synapses;systemic inflammatory response;Techniques;Therapeutic;Thermogenesis;Tissues;translational study;two photon microscopy;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelium;Work;World Health Organization

PROJECT_TITLE: Targeting adipose tissue thermogenesis for age-related vascular cognitive impairment

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Female-controlled prevention methods against sexual HIV-1 transmission and pregnancy are critically needed. Here, we propose to develop an innovative platform for long-acting HIV prevention and contraception by integrating antiviral drug delivery onto an innovative shape-memory copper-containing intrauterine device. This approach will empower and provide women with a multipurpose technology for effective control of their reproductive health.

PI_NAMEs: JENSEN, JEFFREY T.;WOODROW, KIM A. (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Address;Adherence;AIDS prevention;Alloys;Anatomy;Anti-Retroviral Agents;Anti-viral Agents;Atopobium vaginae;Benchmarking;Biopsy;Cells;Cervical;cervicovaginal;Cervix Uteri;Chemicals;Circulation;Clinical;Clinical Data;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Copper;Copper Intrauterine Devices;cytokine;Cytology;Data;Development;Device Designs;Devices;Dose;Drug Delivery Systems;drug efficacy;Drug Formulations;Drug Kinetics;Drug resistance;efficacy evaluation;efficacy study;Electrospinning;empowerment;Endocervix;Endometrial;Endometrium;Ethylenes;Exocervix;FDA approved;Female;flexibility;global health;Health;Health Priorities;HIV;HIV-1;HIV/AIDS;Hormones;Human;implantable device;Inflammatory;Injectable;innovation;Intrauterine Devices;Lead;Levonorgestrel;Licensing;Macaca;Macaca mulatta;Measurement;Measures;Memory;Methods;microbicide;microbiota;Modeling;Monitor;Mucous Membrane;next generation;novel;Operative Surgical Procedures;Oral;pandemic disease;Papio;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;polydimethylsiloxane;Polyurethanes;Positioning Attribute;pre-exposure prophylaxis;Pregnancy;prevent;Prevention;Prevention strategy;Prodrugs;protective efficacy;Proteins;prototype;Recording of previous events;Reporting;Reproductive Health;Safety;Serum;sexual HIV transmission;Shapes;simian human immunodeficiency virus;Site;Solid;Solubility;Study models;success;Surgical sutures;System;Systemic infection;Technology;Tissues;transmission process;treatment as prevention;ultrasound;unintended pregnancy;user-friendly;Uterine cavity;Uterus;Vagina;vinyl acetate;Viral;Width;Woman

PROJECT_TITLE: A low-profile copper intrauterine device that delivers long-acting contraception an

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Sepsis

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: PROJECT NARRATIVE Candida albicans is the leading fungal pathogen of humans, responsible for ~100 million mucocutaneous infections and ~500,000 invasive infections every year; despite the devastating impact of these diseases, only a handful of drugs are available for treating invasive infections, with mortality reaching ~40%. This project will build and leverage the most comprehensive functional genomic resource for a fungal pathogen to provide a global view of genes that are required for this opportunistic pathogen to thrive in the host and cause disease. By developing high-quality comprehensive datasets and strain resources for the community using cutting-edge methods, this investment will transform the field, yielding unexpected biological insights and facilitating the development of much-needed antifungal drugs.

PI_NAMEs: COWEN, LEAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Alleles;Aneuploidy;Animal Disease Models;Anoxia;anti-fungal agents;Bar Codes;Biological;Biological Assay;Blood Circulation;Candida albicans;Candidiasis;Carbon;Carbon Dioxide;Cell Physiology;Cells;Cellular Morphology;Cellular Structures;Cessation of life;Clinical;Collection;Communities;Cost of Illness;Cues;Data Set;Defect;Development;Diagnostic tests;Diploidy;Disease;Dissection;Drug resistance;Drug Targeting;drug testing;Economics;Engineering;Essential Genes;Filament;Filtration;fitness;Fostering;functional genomics;Funding;Fungi Model;fungus;Gene Expression;gene replacement;Genes;Genetic;genetic analysis;genetic approach;genetic resource;Genome;genome resource;genome wide screen;genome-wide;genomic platform;gut colonization;Health;high resolution imaging;high throughput analysis;Hospitals;Human;human disease;human pathogen;Image Analysis;Immune;immunoregulation;In Vitro;in vitro testing;in vivo;Infection;insight;Investments;Life;machine learning model;Macrophage;Messenger RNA;Methods;Modeling;Molecular;Morphogenesis;mortality;mouse model;Mus;mutant;Mutation;next generation sequencing;novel;novel therapeutic intervention;opportunistic pathogen;Organism;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Patients;Persons;Phagocytosis;Pharmaceutical Preparations;Phenotype;Positioning Attribute;programs;promoter;Protocols documentation;public database;Resolution;Resources;response;RNA;RNA Splicing;Saccharomycetales;screening;Sepsis;Serum;social;Source;Symbiosis;Systemic infection;Systems Biology;Temperature;Testing;Tetracyclines;Toxic effect;trait;Transcript;transcription factor;transcriptomics;Validation;Virulence;whole genome;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Anxiety and stress are recognized as major contributors to the motivation as to why people use alcohol to excess. This study focuses on gaining understanding into the mechanisms by which alcohol modulates anxiety. Specifically, this work will characterize a potential genetic source of individual variability in stress-dependent alcohol misuse.

PI_NAMEs: GNATOWSKI, EMMA  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Age;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol relapse;alcohol response;alcohol risk;alcohol use disorder;Alcohols;Alternative Splicing;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety-like behavior;anxiety-related behavior;Automobile Driving;axon growth;Behavior;behavioral response;Bioinformatics;Biological Assay;Brain region;Candidate Disease Gene;Centrosome;Chronic stress;comorbidity;Complex;CRISPR/Cas technology;Cytoplasm;Darkness;Data;Development;Disease;drinking;drinking behavior;Drug Addiction;emotion regulation;Environmental Risk Factor;Ethanol;executive function;Exons;Foundations;Gene Delivery;gene network;Genes;Genetic;Genetic Variation;Genomics;Inbreeding;individual variation;insertion/deletion mutation;International;Knock-out;Knockout Mice;Knowledge;Laboratories;Light;Microtubule-Associated Proteins;Microtubules;Minus End of the Microtubule;Modeling;Molecular;Morphology;Motivation;Mouse Strains;Mus;National Institute on Alcohol Abuse and Alcoholism;negative affect;Neurobiology;Neurons;Neurotransmitters;ninein;novel;Patient Self-Report;Persons;Phenotype;Population;preference;Property;protein function;Protein Isoforms;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;Quantitative Trait Loci;Recombinants;Research;RNA Splicing;Role;Source;Stress;stress disorder;stress reduction;Synaptic plasticity;Tamoxifen;Testing;trafficking;trait;Transcript;transcriptome sequencing;United States;Variant;Viral Vector;Withdrawal;Work

PROJECT_TITLE: The Role of Ninein in Ethanol Anxiolysis


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Automating the Discovery of Clinically-Relevant Intracellular Signaling Responses in Immune Cell-Types Technological advancements in high-parameter mass cytometry (CyTOF) have enabled comprehensive charac- terization of the immune system at unparalleled depths in clinical settings. Ex-vivo stimulation is used to identify clinically-predictive intracellular signaling responses across immune-cell types, but the data produced 1) require an extensive amount of manual labor to analyze and 2) generates a large number of immunological features that do not all directly describe canonical signaling pathways. This project will develop algorithms to integrate single-cells across patient, clinical outcomes, and stimulation conditions to automatically identify cell-populations with clinically-predictive intracellular signaling responses to stimulation.

PI_NAMEs: STANLEY, NATALIE M (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aging;Algorithms;automated analysis;Bioinformatics;Biological Assay;cell type;Cells;Clinic;Clinical;clinical phenotype;clinical predictive model;clinical predictors;clinically relevant;cohort;Collection;combinatorial;Computer Analysis;Consumption;COVID-19 patient;cytokine;Cytometry;Data;Dendritic Cells;Diagnostic tests;Disease;experimental study;Face;Foundations;FRAP1 gene;Frequencies;frontier;Functional impairment;Graph;Immune;Immune signaling;Immune system;Immunologic Stimulation;Immunologics;immunoregulation;innovation;Interferons;Joints;Learning;learning strategy;Left;Ligands;Link;Machine Learning;Manuals;Maps;Measurement;Methods;Modeling;novel;Outcome;Patients;Population;post SARS-CoV-2 infection;Production;protein biomarkers;Research;response;Running;Sampling;Signal Pathway;Signal Transduction;Technology;Therapeutic Intervention;Time;Toll-like receptors;Trauma;Vaccine Design;Virus Diseases;Work

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The lack of valid and reliable RDoC behavioral tasks and measures for identifying areas of overlap and distinction between negative and positive motivational systems in the human brain represents a significant barrier to public health research on a variety of neuropsychiatric disorders. The long-term goal of this project is to demonstrate the psychometric strength and the diagnostic and predictive validity of a user-friendly AP-AV task that we’ve developed for use in behavioral and neuroimaging research. Outcomes of this project include a flexible paradigm for immediate use in human research, and empirical data that lay the foundation for future investigations into the paradigm’s suitability for use with individuals who vary widely in age, ability, and/or severity of distress and/or dysfunction.

PI_NAMEs: SCHLUND, MICHAEL W.;TONE, ERIN BROOKE (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;Adult;Affect;Affective;Age;Anhedonia;Anterior;Anxiety;anxious;approach behavior;Area;avoidance behavior;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Brain;Characteristics;Clinical assessments;clinically significant;Cognition;Cognitive;cognitive control;Conflict (Psychology);Corpus striatum structure;Data;design;Development;Diagnostic;Disease;Distress;Dose;Ecological momentary assessment;emotion regulation;Emotional;Exhibits;flexibility;Foundations;Frequencies;Fright;Functional disorder;Future;Goals;Human;Image;Individual;innovation;Instruction;Insula of Reil;Investigation;Life;Matched Group;Measurement;Measures;Mental Depression;Mental Health;Methodology;Modeling;Moods;Motivation;Negative Valence;neural;neuroimaging;neuropsychiatric disorder;Outcome;Participant;Persons;Positive Valence;Probability;Property;Psychometrics;Psychoses;Psychosocial Assessment and Care;public health research;recruit;Regression Analysis;Reporting;Research;Research Domain Criteria;Research Project Grants;response;Rewards;Severities;Sex Differences;social;social anxiety;social learning;Standardization;stem;System;Testing;theories;user-friendly;Visual;Work

PROJECT_TITLE: Assessment of approach-avoidance motivation in neuropsychiatric disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This research will contribute to determining whether cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.

PI_NAMEs: SEBASTIAN, RAJANI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adjuvant;Affect;Aftercare;Anodes;Anomia;Aphasia;aphasia rehabilitation;Area;Award;Biological Markers;Brain;Cerebellum;Characteristics;Chronic;Cognitive;Communication;Communication Disability;Complication;computerized;Contralateral;Data;design;Diffusion Magnetic Resonance Imaging;Double-Blind Method;Effectiveness;effectiveness evaluation;electric field;Electrical Stimulation of the Brain;evidence base;Exhibits;Functional Magnetic Resonance Imaging;Goals;Image;Impairment;improved;Individual;individual response;interest;Language;Language Therapy;Left;Lesion;lexical;Linguistics;Measures;Middle frontal gyrus structure;Mission;Motor Cortex;Names;National Institute on Deafness and Other Communication Disorders;neural;Neuronal Plasticity;Neurons;neuroregulation;NIH Program Announcements;noninvasive brain stimulation;novel;Outcome;Painless;Participant;Pathway interactions;Patients;Persons;Phase;Phase II Clinical Trials;phase III trial;Philadelphia;post stroke;predicting response;Prevalence;prevent;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Research;Residual state;Resolution;Rest;Retrieval;safety and feasibility;secondary outcome;semantic processing;Semantics;Severities;Site;skills;Source;Speech;Speech Therapy;standard care;Stroke;stroke patient;stroke-induced aphasia;structural imaging;Structure;Techniques;Testing;Tissues;transcranial direct current stimulation;Treatment Effectiveness;Treatment Efficacy;Treatment outcome;treatment response;United States;Work

PROJECT_TITLE: Cerebellar stimulation for Aphasia Rehabilitation

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Infectious Diseases;Pediatric

PHR: Human cytomegalovirus (HCMV) causes major disease in neonates and transplant patients. HCMV infects many different cell types, by using different viral glycoproteins and our studies will focus on how HCMV glycoproteins mediate virus entry into different cells. These HCMV glycoproteins are also major targets of host immunity and the subject of intense interest for vaccines and we will study human anti-glycoprotein antibodies.

PI_NAMEs: JARDETZKY, THEODORE S;JOHNSON, DAVID C. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Response;Benign;Binding;Biochemical;Blood Vessels;Capsid;Cell surface;Cell Surface Receptors;cell type;Cells;Cellular Membrane;Complex;Cytomegalovirus;Cytomegalovirus Vaccines;Cytoplasm;Data;Defect;design;Development;Disease;Endosomes;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Epitopes;experimental study;Fetal Development;Fibroblasts;follow-up;Foundations;Glycoproteins;graft failure;Grant;Hepatitis;Hepatocyte;Herpesviridae;Human;human imaging;Image;Immune system;Immune Targeting;Immunity;Immunize;immunosuppressed;in vivo;Infection;interest;Macrophage;Maps;Mediating;Membrane Fusion;Modeling;Molecular Conformation;monocyte;Mutagenesis;mutant;neonate;Nervous System;Neuroglia;neutralizing antibody;Newborn Infant;organ transplant rejection;Oryctolagus cuniculus;particle;Pathology;Pathway interactions;PDGFRB gene;Peptides;Platelet-Derived Growth Factor alpha Receptor;Pneumonia;Prevalence;Production;Property;Proteins;receptor;Receptor Cell;Role;Site;Structure;Structure-Activity Relationship;synergism;Systemic disease;Testing;trafficking;Transplant Recipients;Tropism;Vaccines;Viral;Viral Fusion Proteins;Virion;Virus;Virus Diseases

PROJECT_TITLE: Human Cytomegalovirus Entry into Cells Mediated by Pentamer and Trimer Complexes

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Autoimmune-mediated eye disease is a pathological hallmark of multiple systemic autoimmune diseases. With a severe lack in efficacious treatment options that is driven by a combination of inadequate early detection strategies and a poor understanding of disease mechanisms, patients suffer life-long morbidity. Using innovative new technologies, we seek to define the mechanisms driving dry eye disease development at the single cell level, with the goal of discovering new targets for therapeutic intervention.

PI_NAMEs: KNOX, SARAH MONICA (contact);MCNAMARA, NANCY A

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Anterior;Anti-Inflammatory Agents;aqueous;Autoimmune;Automobile Driving;Awareness;Cell Differentiation process;Cell Lineage;Cell Nucleus;cell type;Cells;Chronic;Clinical;Cornea;Corneal Diseases;corneal epithelium;curative treatments;Data;Development;Diagnostic;Disease;Disease Progression;driving force;Dry Eye Syndromes;Early Diagnosis;Early Intervention;efficacious treatment;Endothelial Cells;Epithelial Cells;Epithelium;Exocrine Glands;Eye;Eye diseases;eye dryness;gene network;Generations;Genetic;Genetic Variation;Goals;Heterogeneity;Homeostasis;Human;Hyperplasia;Impairment;Inbred BALB C Mice;Infiltration;Inflammation;Inflammatory;innovation;insight;Lacrimal gland structure;limbal;Lupus;Maps;Mediating;microbial;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;nerve supply;Neural Crest;new technology;new therapeutic target;novel;ocular surface;Onset of illness;Organ;Outcome;Outcome Study;Pathologic;Patients;Population;prevent;Process;repaired;Rheumatoid Arthritis;self-renewal;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Sjogren's Syndrome;stem cell population;stem cells;stemness;Stromal Cells;stromal progenitor;systemic autoimmune disease;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Defining mechanisms driving dry eye disease progression

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative We are proposing to establish the Indiana University Bloomington Center for Cannabis, Cannabinoids, and Addiction to support drug abuse researchers across the central Midwest and around the nation. The Center consists of research cores to support the work of these researchers as they measure lipid biomarkers associated with addiction and apply cutting-edge optical imaging to learn how drug addiction affects brain anatomy and function. The Center will also have a strong educational component to bring more researchers into drug addiction research, particularly drawing from populations not well-represented in the field and to train scientists in the cutting-edge technologies used in the Center.

PI_NAMEs: MACKIE, KENNETH  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Address;Affect;Age;Anatomy;Applications Grants;awake;Behavioral;Biological;Biological Markers;Brain;Cannabinoids;Cannabis;career;Cell Physiology;Chronic;Collaborations;compulsion;Creativeness;Cultured Cells;Data;data dissemination;Data Storage and Retrieval;Dopamine;Drug abuse;Drug Addiction;Education;Endocannabinoids;Ensure;equipment acquisition;experience;experimental study;Fostering;Foundations;Functional Imaging;Funding;Goals;Grant;high resolution imaging;Home;Illinois;Image;imaging approach;imaging modality;Imaging Techniques;In Vitro;in vivo;in vivo calcium imaging;Indiana;Individual;innovation;Institution;Intake;interest;Kentucky;Knowledge;Learning;Letters;Light;lipid mediator;Lipids;Mass Spectrum Analysis;Measures;Mentors;microscopic imaging;Microscopy;Midwestern United States;Modality;Molecular;multi-photon;multimodality;multiphoton imaging;multiphoton microscopy;Mus;nanoscale;National Institute of Drug Abuse;Neuromodulator;Neurosciences;non-drug;novel;novel strategies;Ohio;operation;optical imaging;Optics;outreach;Paper;Participant;Pathway interactions;Pattern;Pharmaceutical Preparations;phytocannabinoid;Pilot Projects;Plasma;Population;Predictive Factor;preservation;prevent;Process;Productivity;programs;Public Health;Publishing;Qualifying;reconstruction;Recording of previous events;Relapse;Research;Research Personnel;Resources;Running;Sampling;Scanning;Scientist;sensor;Serotonin;Services;Signal Transduction;Slide;Specimen;STEM career;Structure;Substance Use Disorder;superresolution microscopy;Talents;Techniques;Technology;Thinking;tissue fixing;Training;Underrepresented Populations;underserved minority;United States National Institutes of Health;Universities;university student;West Virginia;Withdrawal;Work

PROJECT_TITLE: Indiana University Bloomington (IUB) Center for  Cannabis, Cannabinoids, and Addiction (C3A)


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Substance Misuse

PROJECT_TERMS: addiction;Animals;Archives;Brain;Cannabinoids;Cannabis;Collaborations;Communication;Communities;Community Outreach;Data;data management;Data Set;Development;distinguished professor;Drug abuse;Drug Addiction;Endowment;Ensure;Evaluation;Event;experience;Faculty;falls;follow up assessment;follow-up;Funding;Gills;Goals;graduate student;Growth;improved;Indiana;interest;Internet;large datasets;Learning;Letters;meetings;member;Microscopy;Mission;multidrug abuse;National Center for Complementary and Integrative Health;National Institute of Drug Abuse;National Institute of Neurological Disorders and Stroke;Neurosciences;new technology;Office of Administrative Management;operation;Paper;Pilot Projects;Play;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;psychologic;Publishing;recruit;Research;Research Personnel;Resources;Role;Scholarship;Science;Scientist;Services;social media;Structure;Students;success;Suggestion;summer research;symposium;System;Techniques;Technology;tenure track;Time;Training and Education;Travel;undergraduate student;Universities;Washington

PROJECT_TITLE: IUB C3A Administrative Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Genetics;Human Genome;Nutrition;Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE Peanut Allergy (PA) has emerged as a major clinical and public health problem worldwide. This prospective birth cohort study aims to investigate T cell receptor ß-chain (TCRß) repertoire features and changes during the first two years of life in relation to the risk of developing PA; and further examine the interplay of TCRß repertoires with potentially modifiable early life factors such as nutrition and metabolomic alteration on PA. Successful completion of this study will help to identify novel biomarkers for early risk assessment and new targets for effective interventions during the earliest developmental windows when they may have the greatest life-long benefit.

PI_NAMEs: HONG, XIUMEI  (contact);SMITH, KELLIE NICOLE

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adaptive Immune System;Adult;Affect;Age;Alleles;Allergens;Allergic;Allergy to peanuts;Antigens;Attention;Bar Codes;beta Chain Antigen T Cell Receptor;Biological Assay;biological specimen archives;Birth;Black race;Boston;Breast;Breast Feeding;CD4 Positive T Lymphocytes;Cells;Child;Childhood;Clinical;clinical database;cohort;Cohort Studies;complementarity-determining region 3;cost;Data;Databases;design;Development;DNA;early childhood;early detection biomarkers;early life exposure;effective intervention;effector T cell;Epidemiology;Ethics;Exposure to;feeding;Folic Acid;Food Hypersensitivity;Funding;Genetic Risk;genetic variant;genome wide association study;genome-wide;Genotype;Goals;Haplotypes;high risk;Histocompatibility Antigens Class II;HLA Antigens;Hypersensitivity;Immune response;Immunity;in utero;Individual;Infant;Intervention;Investigation;Joints;Latinx;Life;Mediating;Metabolic;Metabolism;metabolome;metabolomics;minority children;Molecular;Monitor;multi-ethnic;multidisciplinary;multiple omics;Not Hispanic or Latino;novel;novel marker;nutrition;Nutritional;Nutritional status;Peripheral Blood Mononuclear Cell;Play;Population;postnatal development;Prevalence;Probability;prospective;protective factors;Public Health;Regulatory T-Lymphocyte;Reporting;Research;Resources;response;Risk;Risk Assessment;Risk Factors;risk prediction;Role;Sampling;Sorting;Specificity;Systems Development;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Thymus Gland;Time;United States National Institutes of Health;Vitamin D;Work

PROJECT_TITLE: Interplay of the T Cell Repertoire Development and Early Life Exposure on Incident Risk of Peanut Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]