NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Atypical teratoid rhabdoid tumors (ATRTs) are aggressive pediatric brain cancers that are caused by loss-of- function mutations of the SMARCB1 gene, which results in formation of poorly differentiated cells that undergo uncontrolled proliferation. This proposal aims to uncover how SMARCB1 loss interacts with cell type and anatomical location to drive tumorigenesis and to identify druggable pathways that can push SMARCB1-depleted cells forward through cellular differentiation, thus halting tumor growth. If successful, these findings could lead to the development of therapeutic strategies that can replace currently used brain radiation therapies for ATRTs that harm the cognitive development of pediatric patient survivors.

PI_NAMEs: WANG, CLARK GOLD (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acute Promyelocytic Leukemia;Alleles;Anatomy;Biology;Brain;Brain Neoplasms;Cancer Etiology;Candidate Disease Gene;Cell Differentiation process;cell type;Cells;Central Nervous System;Cephalic;chemotherapy;Child;Childhood;Childhood Malignant Brain Tumor;Chromatin Remodeling Factor;Clinical;cognitive development;Combined Modality Therapy;Complex;Cranial Irradiation;Cranial Nerves;CRISPR screen;Defect;Differentiated Gene;drug candidate;Drug Targeting;Embryo;Engraftment;Enhancers;Excision;Exhibits;experimental study;Gene Expression Profile;Gene Expression Profiling;Human Engineering;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;insight;Inter-tumoral heterogeneity;Isopropyl Thiogalactoside;knock-down;Location;loss of function mutation;Malignant - descriptor;Mediating;melanocyte;Methods;migration;Modeling;Molecular;Mutation;NCAM1 gene;nerve stem cell;neural;Neural Crest Cell;Neurocognitive;Neuroectoderm;Neuronal Differentiation;Neurons;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;Outcome;Pathway interactions;pediatric patients;Pharmaceutical Preparations;Pharmacotherapy;Proliferating;Radiation;Radiation therapy;Recurrence;Rhabdoid Tumor;Role;Schwann Cells;SHH gene;SMARCB1 gene;Sorting;Standardization;Subcellular Anatomy;subcutaneous;Subgroup;Survivors;Therapeutic;therapeutic development;transcriptome;transcriptome sequencing;Treatment Protocols;tumor;tumor growth;tumorigenesis;Validation

PROJECT_TITLE: Generating hiPSC-derived ATRT models to investigate cell of origin and identify therapeutic vulnerabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: Bariatric surgery is currently one of the most effective treatments for sustained weight loss and improved glycemia in individuals with obesity and type 2 diabetes. Despite the metabolic benefits of bariatric surgery, one third of patients suffer from low blood sugar (hypoglycemia), which when left untreated, can lead to cognitive deficits, serious accidents, and even sudden death. This project will investigate if hypoglycemia sensing within the brain is blunted after bariatric surgery, leading to improper physiological responses to raise blood glucose back to safe levels.

PI_NAMEs: COOK, TYLER  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Accidents;Animals;antagonist;Back;bariatric surgery;Blood Glucose;blood glucose regulation;blood-brain barrier crossing;Body Weight decreased;Brain;Brain Injuries;Brain region;Cannulas;Cannulations;Central Nervous System;Closure by clamp;Cognitive deficits;Complex;Data;Deoxyglucose;Detection;Dose;Drops;Eating;effective therapy;Endocrine;energy balance;experience;experimental study;feeding;Feeding behaviors;Fellowship;Female;FGF19 gene;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Future;Gastrectomy;Gastric Bypass;Glucose;Glucose Clamp;glucose metabolism;glucose sensor;Glycolysis;Goals;High Prevalence;hindbrain;Hormonal;Hormones;Hunger;Hyperinsulinism;Hypoglycemia;Hypothalamic structure;Immunofluorescence Immunologic;Impairment;Implant;improved;Incidence;Individual;Injections;Insulin;insulin sensitivity;Intervention;Left;male;Measures;Metabolic;Molecular;mouse model;Mus;neural;neural circuit;Neurologic Symptoms;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Operative Surgical Procedures;Pathogenesis;Patients;Persons;Physiological;Positioning Attribute;pre-clinical;prevent;Quality of life;Reactive hypoglycemia;Research;Research Personnel;response;Role;sex;Signal Transduction;stem;success;Sudden Death;Symptoms;Testing;therapeutic target;Time;Training;treatment strategy;Weight;Work

PROJECT_TITLE: The role of diminished CNS hypoglycemia sensing in postbariatric hypoglycemia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Stroke is the third leading cause of disability globally, and the number of incident strokes is expected to increase substantially as the size of the population aged 65 and older grows. After a stroke, some patients experience an accelerated decline in cognitive and functional ability, while disability stabilizes for other patients. We will leverage two studies to evaluate the relationship between life-space and long-term cognitive decline after stroke.

PI_NAMEs: DOBROTA LAI, SYLVIE DIANE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Aging;Area;Award;cardiovascular health;career;career development;Cellular Phone;Clinical;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive disability;cognitive function;cohort;Complex;Data;Data Analyses;Data Collection;digital health;disability;doctoral student;Enrollment;Environment;Epidemiology;Exercise;experience;Fellowship;Foundations;Frequencies;Future;Gait speed;Genetic;high risk;Home;human old age (65+);Impaired cognition;Individual;Ischemic Stroke;Leisures;Life;Measures;medical schools;Mentors;Mentorship;Methodology;Methods;Mobility decline;Modernization;Neurology;Neurosciences;novel;older adult;Outcome;Participant;Patients;Pattern;Persons;Physical activity;Physical Function;population health;Population Sizes;Positioning Attribute;post stroke;post stroke cognitive impairment;prospective;Prospective cohort;protective effect;Proteomics;Questionnaires;Recreation;Research;Research Personnel;Research Training;response;skills;smartphone application;social;social engagement;statistics;Stroke;stroke cognitive outcome;stroke patient;stroke survivor;Telephone;theories;Time;tool;Training;Training Programs;Travel;Work

PROJECT_TITLE: Lifespace mobility and cognitive decline after stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: IRVINE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Transposable elements are prevalent selfish DNA sequences present in many organisms, and they constitute about 45% of the human genome. Their activity and abundance are related to their ability to cause inherited diseases and cancers, including breast cancer, colon cancer, and leukemia. The proposed research will identify factors that influence the abundance of transposable elements and determine their consequences on host function and fitness, with strong implications for human health and disease states.

PI_NAMEs: LEE, GRACE YUH CHWEN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3-Dimensional;Affect;Biochemical;Cellular biology;chromatin modification;Colon Carcinoma;comparative;Disease;DNA;DNA Insertion Elements;DNA Sequence;DNA Transposable Elements;Drosophila genus;Epigenetic Process;Evolution;Exhibits;Fertility;fitness;Genes;Genetic;Genetic Processes;Genome;genome-wide;Genomics;Goals;Grant;Health;Hereditary Disease;Human;Human Genome;Inherited;Laboratories;leukemia;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modeling;Molecular;novel;Nuclear;Organism;Parasites;parent grant;Persons;Positioning Attribute;programs;Research;RNA;Role;Salamander;Selfish DNA;Shapes;species difference;Structure;Tetraodontidae;Variant;vertebrate genome

PROJECT_TITLE: How transposable elements drive genome evolution through epigenetic mechanisms


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative While it is understood that the innate immune system plays a role io osteoarthritis disease progression and symptomatology, it is not known the role it plays io the subchondral bone. I will iovestigate the role TLR plays io the osteoclast secretome and how this affects osteoblastogenesis as well as T cell migration. With this, I hope to be able to develop new therapeutics modulating inflammation and bone remodeliog in the subchondral bone.

PI_NAMEs: MURPHY, LANCE AVERY (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Anatomy;Antiinflammatory Effect;Area;Attenuated;Automobile Driving;Behavior;Binding;Biological Assay;bone;Bone Marrow;Bone remodeling;Bone Resorption;Cartilage;cartilage degradation;CD14 gene;CD4 Positive T Lymphocytes;cell motility;Cells;chemokine;Chemotactic Factors;Chemotaxis;Chronic;Complement 3a;Complement 5a;cytokine;Cytometry;Data;Degenerative polyarthritis;Development;disability;Disease;Disease Progression;Ensure;Fibroblasts;Flow Cytometry;Homeostasis;Image;Immune;immunoregulation;improved;In Vitro;Infiltration;Inflammation;Inflammatory;Innate Immune System;joint injury;Joints;Lipopolysaccharides;Macrophage;Mediating;Mediator;Membrane;Mentors;Mesenchymal;migration;Migration Assay;Modeling;Modification;Molecular;mouse model;Mus;Natural Killer Cells;new therapeutic target;novel;novel therapeutics;Osteitis;osteoblast differentiation;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;Pain;Pathology;Pathway interactions;Phenotype;Play;Production;RANTES;receptor;Receptor Activation;Receptor Signaling;release factor;Role;Signal Transduction;skills;Source;subchondral bone;symptomatology;Synovial Fluid;Synovial Membrane;Synovitis;System;T-Lymphocyte;Testing;Therapeutic Intervention;Tissues;TLR4 gene;Toll-like receptors;tool;Traumatic Arthropathy;Wild Type Mouse;Work

PROJECT_TITLE: The impact of TLR signaling on osteoclast-mediated bone remodeling and inflammation in osteoarthritis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Patient Safety;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because elucidating the impact of germline genetics on the natural history of low-grade prostate cancers will help promote active surveillance in most men at high genetic risk by increasing their confidence that surveillance is safe for them. And, this research will help identify the subset of men with high-risk tumor features that might benefit from earlier treatment. In line with the NCI’s mission, this proposed research will allow for many men at high genetic risk to avoid overtreating their low-grade prostate cancers without risking an untreatable disease progression.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: active method;Award;Benefits and Risks;Biochemical;Biology;BRCA2 gene;Cancer Biology;cancer biomarkers;cancer epidemiology;career development;carrier status;Characteristics;Clinical;Clinical Management;clinically actionable;cohort;Cohort Studies;Counseling;course development;Data;deep learning algorithm;design;Development Plans;Diagnosis;Disease;Disease Management;Disease Progression;disease-causing mutation;disorder risk;Early treatment;Enrollment;Exhibits;experience;Family;Family history of;FDA approved;Genes;Genetic;genetic epidemiology;Genetic Risk;Genomics;Germ Lines;Germ-Line Mutation;Goals;Guidelines;high risk;improved;Individual;Inherited;innovation;insight;interest;Investigation;Link;Localized Disease;Loss of Heterozygosity;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Mentors;Mentorship;Metastatic Prostate Cancer;Mission;Modeling;Molecular;Monitor;Mutation;mutation carrier;Natural History;Outcome;Pathogenicity;Pathology;patient population;patient subsets;Patients;Pattern;Play;polygenic risk score;progression risk;prospective;Prostate;prostate cancer risk;Protocols documentation;Provider;PTEN gene;Public Health;rare cancer;Recommendation;Recording of previous events;Recurrence;Research;Research Personnel;response;Risk;risk prediction;risk stratification;risk variant;Role;Scientist;Serinus;Somatic Mutation;standard of care;Surgeon;surveillance study;Testing;Treatment outcome;tumor;tumor progression;Variant

PROJECT_TITLE: Measures of Inherited Prostate Cancer Risk in the Management of Low-Grade Prostate Cancers on Active Surveillance

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Persistent DNA bridges are manifestations of genomic instability, a hallmark of cancer, and arise with replication stress, telomere dysfunction, and errors in double-strand break repair. My proposed studies will elucidate the mechanisms of innate immune activation by persistent DNA bridges arising from PARP inhibitor treatment in DNA repair-deficient hereditary breast and ovarian cancer. These studies could lead to the development of potential predictive biomarkers of PARP inhibitor response, as well as novel insights that can maximize the therapeutic potential of PARP inhibitor treatment in DNA repair-deficient tumors.

PI_NAMEs: KOCAK, ECE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acceleration;Affect;Anaphase;Antibodies;Archives;Automobile Driving;Basic Science;Biological Assay;Biology;Biopsy;BRCA deficient;BRCA1 gene;Breast Cancer Patient;Cancer Biology;cancer cell;Cancer cell line;cancer therapy;career;Cell Cycle;Cell Death;Cells;Chromatids;Chromosomal Instability;Chromosome Segregation;Clinical;collaborative environment;Cultured Cells;cytokine;Cytopathology;Cytoplasm;cytotoxicity;Data;Data Analyses;Defect;Development;digital imaging;DNA;DNA biosynthesis;DNA lesion;DNA Repair;DNA Repair Disorder;Double Strand Break Repair;Educational process of instructing;Electron Microscopy;Enzyme Immunoassay;Enzyme-Linked Immunosorbent Assay;Exhibits;Experimental Designs;Failure;fluorescence imaging;Frequencies;Functional disorder;Genome;Genomic Instability;Hematoxylin and Eosin Staining Method;Hereditary Breast and Ovarian Cancer Syndrome;Imaging Techniques;Immune;immune activation;Immunofluorescence Immunologic;Immunohistochemistry;Immunooncology;immunoregulation;Immunotherapy;improved;in situ imaging;innate immune mechanisms;Innate Immune Response;insight;Interferon Type I;Knowledge;Label;Lead;light microscopy;live cell imaging;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mentors;Mentorship;Microscopy;Mitotic;Molecular;Molecular Biology;mRNA Expression;Mutagens;mutant;neoplastic cell;next generation;novel;novel marker;Nuclear;Nuclear Envelope;Oral;Paraffin Embedding;Pathology;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;potential biomarker;predictive marker;Preparation;Prevalence;prevent;Production;Proteins;recruit;repaired;replication stress;Research;Resistance;Resolution;response;Role;Rupture;Sampling;Scientist;segregation;sensor;Signal Transduction;skills;Somatic Cell;Stains;Stimulator of Interferon Genes;Stretching;Structure;supportive environment;Surface;synergism;Technical Expertise;telomere;Testing;Therapeutic;therapy resistant;Tissue Microarray;Tissues;tool;Training;Translational Research;Transposase;tumor;Western Blotting;Work;Writing;XCL1 gene

PROJECT_TITLE: Defining the role of persistent DNA bridges in tumor-intrinsic immune activation in hereditary breast and ovarian cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Sudden cardiac death due to ventricular arrhythmias is a major public health concern, accounting for 10-20% of all deaths in adults in the United States. Current therapeutics for these fatal arrhythmias are underdeveloped, fail to target the underlying disease cause, and lack the mechanism of action to increase longevity and quality of life for patients. Anti-arrhythmic therapeutics will be developed and studied to potentially target ventricular arrhythmias.

PI_NAMEs: THORPE, MADELAINE PAIGE (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Academic Medical Centers;Accounting;Adult;Affect;Amides;analog;Anti-Arrhythmia Agents;Arrhythmia;Behavior;Biological;Biological Assay;Calcium;Calcium Channel;Cardiac Myocytes;Categories;Cell membrane;Cell Membrane Permeability;Cells;Cellular Membrane;Cessation of life;Characteristics;Chemicals;Collaborations;Coupled;Creativeness;Cyclodepsipeptides;Dantrolene;Data;Depsipeptides;design;Development;Diffusion;Disease;Drug Kinetics;efficacy study;Elements;enantiomer;Equilibrium;Esters;Exhibits;Extravasation;falls;Feedback;Flecainide;functional group;Guidelines;Heart;Hydrogen Bonding;improved;in vivo;Individual;inhibitor;innovation;interest;Laboratories;Lead;lipophilicity;Longevity;Measures;Mediating;member;membrane activity;Methylation;Modification;Molecular Conformation;Molecular Weight;Mutation;Natural Products;Nature;novel therapeutics;Partition Coefficient;Patients;Penetration;Peptides;Periodicity;Permeability;Pharmaceutical Preparations;pharmacologic;pharmacophore;Positioning Attribute;preservation;Production;Property;Protein Isoforms;Public Health;Quality of life;Rationalization;release of sequestered calcium ion into cytoplasm;Research;Route;Ryanodine Receptor Calcium Release Channel;RyR1;RyR3;Sarcoplasmic Reticulum;Scientist;Series;single molecule;small molecule;small molecule therapeutics;Solubility;Specificity;stereochemistry;Structure;Structure-Activity Relationship;success;sudden cardiac death;System;Testing;Tetracaine;Therapeutic;tool;Toxic effect;Travel;United States;Variant;Ventricular Arrhythmia;Work

PROJECT_TITLE: Deconvolution of Physicochemical Properties Contributing to Passive Diffusion of Depsipeptides


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Erythroid-myeloid progenitors (EMPs) drives transient-definitive hematopoiesis and gives rise to definitive erythrocytes, megakaryocytes, and monocytes that contribute to the majority of the adult tissue resident macrophage (TRM) populations. However, much remains unknown regarding the genetic requirements for EMP development and differentiation. This study proposes to identify the transcriptional requirements for EMP development and differentiation into monocytes and TRMs, which will further our understanding of fetal hematopoiesis and the impact of TRM heterogeneity in health and disease.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adult;Alleles;ATAC-seq;Binding;Binding Sites;Biological Assay;Brain;career development;Chromatin;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Defect;Development;Disease;Doctor of Philosophy;Embryo;Embryonic Development;Endothelium;Enhancers;Erythrocytes;Erythroid;erythroid differentiation;Erythropoiesis;Exhibits;experience;fetal;Fetal Development;Fetal Liver;Fetus;Flow Cytometry;Genetic;Genetic Enhancer Element;Genetic Transcription;Goals;Harvest;Health;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hepatocyte;Heterogeneity;histone modification;Homeobox;Homeostasis;In Vitro;in vivo;Infection;Institution;Knockout Mice;Knowledge;LoxP-flanked allele;Macrophage;Maintenance;medical schools;Megakaryocytes;Mentors;Methylcellulose;Microglia;monocyte;mouse model;Mus;Mutagenesis;Myelogenous;Myeloid Progenitor Cells;next generation sequencing;novel;novel therapeutic intervention;Phenotype;Physicians;Population;Pregnancy;progenitor;programs;Recording of previous events;Regulatory Element;Reporter;Retroviridae;Role;Scientist;single-cell RNA sequencing;Site;Sorting;Source;stem cell derived tissues;Stem Cell Development;stem cell differentiation;Stem Cell Factor;Surface;System;Technology;Tissues;Training;transcription factor;Transcriptional Regulation;Transgenic Organisms;Travel;Universities;vector;Washington;Yolk Sac;Zinc Fingers

PROJECT_TITLE: The role of EMT transcription factor Zeb2 in fetal hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Hematology;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative We aim to explore the novel hypothesis that resident lung hematopoietic stem and progenitor cells contribute to the lung megakaryocyte pool at steady state and encode an immune modulatory (immune differentiated) phenotype. We also aim to test whether lung megakaryocytes produce immune differentiated platelets. These studies will inform future models of immune differentiated megakaryopoiesis/thrombopoiesis in all tissue environments and their role in coordinated immune responses with direct applications to many vascular diseases.

PI_NAMEs: LIVADA, ALISON CLAIRE (contact)

PROJECT_TERMS: Acceleration;Adult;Automobile Driving;Biological Models;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Cardiovascular Diseases;career;career development;Cells;Colony-Forming Units Assay;Communicable Diseases;Data;daughter cell;Development;direct application;Disease;Dyes;Embryo;Environment;experimental study;Flow Cytometry;Future;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;Homeostasis;Immune;Immune response;Immunofluorescence Immunologic;Immunological Models;Immunology;Immunophenotyping;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;insight;irradiation;Label;Large Megakaryocyte;Lung;Lung Capacity;Lung Diseases;Malaria;Megakaryocytes;Megakaryocytopoieses;Methods;migration;Modeling;Morphology;mouse model;Mus;novel;novel strategies;Oropharyngeal;Parents;Phenotype;Physicians;Physiological;Ploidies;Population;Process;Production;Proto-Oncogene Protein c-kit;pulmonary function;reconstitution;Reporter;Research;Role;Scientist;self-renewal;single-cell RNA sequencing;SLAM protein;Sorting;Source;Spleen;stem cell biomarkers;Sterility;Techniques;Testing;Thrombocytopenia;Thrombopoiesis;Thrombosis;Tissues;trafficking;Training;transcriptome sequencing;Transplantation;Vascular Diseases

PROJECT_TITLE: The Origin and Function of Lung Megakaryocytes


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Cardiac fibrosis is a common contributing factor to heart failure. This project will test novel mechanisms by which pressure overload influences cardiac fibrosis, which could be leveraged to develop new therapies to diminish the burden of heart failure.

PI_NAMEs: NGUYEN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: aorta constriction;Atomic Force Microscopy;Biochemical;Biomedical Research;Blood Vessels;Breeding;Cardiac;Cardiovascular Diseases;Cells;Characteristics;Clinical;Collagen;coronary fibrosis;Critical Thinking;Cues;cytokine;Data;Deposition;Development;Echocardiography;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Genetic Transcription;Growth Factor;Heart;Heart failure;indexing;Inflammatory;injured;Injury;Interleukin-1 beta;Knowledge;Ligands;MAP3K7 gene;Mechanics;Mediating;Mentors;Metabolism;Modeling;Mus;Myocardial;Myocardial Infarction;Myofibroblast;novel;novel therapeutics;paracrine;Paracrine Communication;Pathologic;Pathology;Pathway interactions;Peptide Initiation Factors;pharmacologic;Phenotype;Play;pressure;profibrotic cytokine;Profibrotic signal;programs;Proliferating;Protein Secretion;Proteins;receptor;response;Role;Signal Pathway;Signal Transduction;skills;Stress;Structure;success;Testing;TNF gene;transdifferentiation;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors

PROJECT_TITLE: Fibroblast TAK1 signaling in cardiac fibrosis


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

PHR: PROJECT NARRATIVE The acute respiratory distress syndrome (ARDS) is a common disease with high morbidity and mortality, and the mechanisms which result in some patients recovering rapidly while others experience prolonged inflammation and/or fibrosis are unclear. Pulmonary macrophages play critical roles in the pathogenesis of ARDS by releasing pro-inflammatory cytokines, chemokines, and cytotoxic factors. This proposal will use an existing mouse single-cell RNA sequencing dataset combined with a compartment and lineage tracing mouse model to test the hypothesis that recruited monocyte-derived macrophages drive prolonged inflammation through expression of pro-inflammatory genes and through their continual recruitment to the airspace and pulmonary interstitium.

PI_NAMEs: KING, EMILY MERTENS (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Affect;Alveolar Macrophages;Apoptotic;Automobile Driving;Bacterial Pneumonia;Bleomycin;Bone Marrow;Cells;chemokine;Clinical;cytokine;cytotoxic;Data;Data Analyses;Data Set;Deoxyuridine;Detection;Disease;Embryonic Development;Epithelium;Exhibits;experience;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression Profile;Genes;Genetic Transcription;Heterogeneity;Homeostasis;Hypoxemia;improved;In Situ;indium-bleomycin;Inflammation;Inflammatory;Injury;insight;interstitial;Intervention;Kinetics;Knowledge;Label;Laboratories;Lipopolysaccharides;Lung;lung injury;Macrophage;Mechanical ventilation;migration;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Neutrophil Infiltration;non cardiogenic pulmonary edema;outcome disparities;Pathogenesis;Patients;Physiologic pulse;Play;Population;Proliferating;Pulmonary Fibrosis;Pulmonary Inflammation;recruit;Reporter;Role;Sepsis;single-cell RNA sequencing;Structure of parenchyma of lung;Tamoxifen;Testing;Time;timeline;tissue repair;Tissues;Viral Pneumonia;Work

PROJECT_TITLE: Investigating Recruited Lung Macrophage Programming and Turnover in Self-Limited Versus Prolonged Lung Inflammation


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Kidney Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Access to the outflow vein of an arteriovenous fistula (AVFs), a surgically-created connection between an artery and a vein, is important for clinicians to deliver hemodialysis to patients whose kidneys are failing. Unfortunately, AVFs fail often and unpredictably, thereby complicating patient care. Here we will use new ultrasound imaging methods to study whether the stiffness of the blood vessels surrounding an AVF could be useful for predicting AVF failure.

PI_NAMEs: CAPRON, CHARLES BANFIELD (contact)

PROJECT_TERMS: Adipose tissue;Adoption;Agreement;American;Anastomosis - action;Angioplasty;Animal Model;Animals;Arteries;Arteriovenous fistula;Autologous;Biological Markers;biomarker identification;Blood;Blood Vessels;brachial artery;Carotid Arteries;Catheters;Cephalic;Chronic Kidney Failure;Clinical;Common carotid artery;Contralateral;cryogel;Data;Detection;detection method;efficacy evaluation;Elasticity;End stage renal failure;Equation;experimental study;Failure;Family suidae;Fibrosis;Fistula;Future;Geometry;Glomerular Filtration Rate;Heart;Hemodialysis;Histologic;Histology;Image;imaging modality;Imaging Techniques;improved;in vivo;infection risk;Intervention;Kidney;Legal patent;Libraries;Magnetic Resonance Angiography;Measurement;Measures;Mechanics;Mesenchymal Stem Cells;meter;Methods;Modulus;Operative Surgical Procedures;Patient Care;patient population;Patients;Phase;Physiologic pulse;Placebos;Polyvinyl Alcohol;porcine model;predictive marker;pressure;Pressure Transducers;Probability;Procedures;Process;Pulsatile Flow;Puncture procedure;radial artery;Relative Risks;Renal function;Resistance;Resolution;Scheme;Side;Signal Transduction;Site;spatiotemporal;Speed;stem cell therapy;success;Sum;Techniques;temporal measurement;Test Result;Testing;Time;time interval;time use;Tissues;transmission process;treatment group;Tube;Ultrasonography;ultrasound;United States;Validation;Veins;Venous

PROJECT_TITLE: Improving Ultrasound Pulse Wave Imaging for Prediction of Arteriovenous Fistula Maturation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Lung;Nanotechnology;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Neonatal respiratory distress syndrome and acute respiratory distress syndrome affect hundreds of thousands of Americans every year. They are caused by issues in the lung’s ability to produce functional surfactant. The proposed research will investigate how the fundamental physicochemical organization and limiting behavior of lung surfactant (specifically, the lower surface tension limit) may be used to improve alternative synthetic surfactant therapies and treatment routes for these diseases.

PI_NAMEs: MCALLISTER, ZACHARY D (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 3-Dimensional;Acute Respiratory Distress Syndrome;Admission activity;Affect;Air;Alveolar;Alveolus;American;Animals;Architecture;Area;Atelectasis;Atomic Force Microscopy;Behavior;behavior change;Biological;Blood capillaries;Breathing;Cattle;Chemical Surfactants;Chemicals;Cholesterol;Complex;confocal imaging;Confocal Microscopy;Coupled;COVID-19;Crystallization;Data;Death Rate;Disease;Exhalation;Family suidae;fluorescence microscope;Fluorescence Microscopy;Frequencies;Growth;Image;Immune response;improved;Inflammation;interfacial;Lateral;Life;Lipase;Lipids;Liquid substance;Lung;Maps;Methods;microscopic imaging;Minnesota;Minor;Modulus;monolayer;Morphology;nanometer;Neonatal Respiratory Distress;Palmitic Acids;Patients;Phase;Positioning Attribute;Premature Infant;pressure;prevent;Property;protein distribution;Proteins;Pulmonary Surfactants;Radial;Religion;Research;Resolution;respiratory distress syndrome;Route;segregation;Signal Transduction;Solid;Spatial Distribution;Structure;submicron;Surface;Surface Tension;surfactant;surfactant replacement;surfactant replacement therapy;Surfactant therapy;System;three dimensional structure;Trauma;trend;two-dimensional;Universities;Unsaturated Fats;Visualization;Water;Work

PROJECT_TITLE: Three-dimensional Confocal Microscopy Visualization and AFM-IR Chemical Mapping of Lung Surfactant Monolayer Collapse Morphologies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Atrial fibrillation (AF), estimated to affect 10% of the population over 80, causes significant morbidity and mortality. Despite this, treatment options for AF are insufficient, and current interventions, which are limited by side effects and iatrogenic complications, target symptoms and complications rather than the underlying cause. Understanding the pathogenesis of AF through the biomechanical regulation of its tissue substrate will help discover novel pathways that can be targeted to more effectively modify the natural course of the disease.

PI_NAMEs: GOKHAN, ILHAN  (contact)

PROJECT_TERMS: Affect;American;Animal Model;Anticoagulation;Arrhythmia;Atrial Fibrillation;Atrial Function;Biological Assay;Biomechanics;Biomedical Engineering;Biophysical Process;Bioreactors;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;career;Characteristics;Clinical;clinical imaging;conditioning;Data;design;Development;Disease;disease model;electrical property;Electron Microscopy;Electrophysiology (science);Environment;Esthesia;Evaluation;Fibroblasts;Fibrosis;Foundations;Functional disorder;Future;Gel;Gene Expression;Genes;Genetic Techniques;Goals;Heart Atrium;Heart Diseases;Heart failure;Human;human induced pluripotent stem cells;Iatrogenesis;Impairment;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Inflammatory;Intervention;Investigation;Ion Channel;Kinetics;Knowledge;Learning;Left;Maps;Measures;mechanical force;mechanical load;mechanical properties;Mechanical Stress;Mechanics;Mediating;medical schools;Methodology;Modeling;Morbidity - disease rate;mortality;Motivation;muscle physiology;Myofibroblast;Myosin ATPase;novel;novel strategies;Optics;Pathogenesis;Pathologic;Pathology;Pathway interactions;pharmacologic;Phase;Phenotype;Physicians;Physiological;Physiology;Population;Predisposition;pressure;Protein Analysis;Protein Isoforms;Proteins;Protocols documentation;Pulmonary veins;Quality of life;Regulation;Reproducibility;Resolution;Risk Factors;Role;Scientist;side effect;Signal Transduction;standard of care;stem cell biology;Stress;Stroke;symptom treatment;Symptoms;System;targeted treatment;Techniques;Technology;Testing;Tissues;Training;translational potential;Universities;Up-Regulation;Work

PROJECT_TITLE: Elucidating the Role of Biomechanical Strain in Atrial Physiology and Arrhythmias


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Dana-Farber/Harvard Cancer Center (DF/HCC) will continue to function as a Lead Academic Organization  in the NCI Experimental Therapeutics Clinical Trials Network, with the goal of developing and participating in  network early phase clinical trials utilizing CTEP IND agents as monotherapies or in rational combinations.  The research proposed under this UM1 Cooperative Agreement will translate preclinical science to improved  treatment options for patients with advanced cancer and will accelerate access to new biomarker-driven  therapeutic strategies.

PI_NAMEs: FLAHERTY, KEITH T;KUFE, DONALD W.;SHAPIRO, GEOFFREY I (contact)

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;assay development;Basic Science;Biological Assay;Biological Markers;biomarker development;biomarker driven;Biometry;Biopsy;Cancer Center;Cancer Therapy Evaluation Program;cancer type;career;career development;Catchment Area;Cell Cycle;Cell Line;Center for Translational Science Activities;Clinical;clinical development;Clinical Investigator;Clinical Research;Clinical Sciences;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cohort;Collaborations;Computational Biology;Dana-Farber Cancer Institute;design;Development;Development Plans;Developmental Therapeutics Program;Discipline;Disease;DNA Repair;drug development;Drug Kinetics;Drug resistance;drug sensitivity;early phase clinical trial;Enrollment;experience;Fostering;General Hospitals;Genomics;Goals;Grant;Guidelines;Hospitals;Immunologic Monitoring;Immunooncology;improved;Institution;Intervention;Interventional radiology;Investigational Therapies;Israel;Laboratories;Lead;Leadership;Letters;liquid biopsy;Malignant Neoplasms;Massachusetts;Medical center;meetings;member;Mentors;Mentorship;model development;Molecular;multidisciplinary;novel;oncology trial;Organoids;Outcome;outreach;outreach program;Pathologist;Pathology;Pathway interactions;patient derived xenograft model;patient population;Patient Selection;Patients;Pharmacodynamics;Phase;Population Heterogeneity;pre-clinical;Program Development;programs;protocol development;Protocols documentation;radiologist;Reporting;Reproduction spores;Research;Research Design;Research Personnel;Resistance;Resources;response;Risk Assessment;Role;Safety;Science;Signal Transduction;Site;sound;Structure;success;Therapeutic;Training;Translating;Translational Research;translational scientist;trial design;U-Series Cooperative Agreements;Underserved Population;Woman;Work;working group;Writing

PROJECT_TITLE: Dana-Farber/Harvard Cancer Center Experimental Therapeutics Clinical Trials Network Site (DF/HCC ETCTN Site)


NIH_SPENDING_CATS: Cancer;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: JACKSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Hematopoietic stem cells supply the lifelong foundation of the blood and immune systems and dysregulation in hematopoiesis gives rise to a variety of blood related diseases and cancers. We have identified two natural fatty acid mediators called specialized pro-resolving mediators that are able to increase hematopoietic stem cell number and hematopoiesis. This proposal will address how specialized pro-resolving mediators are able to increase hematopoiesis in vivo and assess their therapeutic potential for blood related diseases and cancers.

PI_NAMEs: NGUYEN, KIM UYEN (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adult;Affect;Agonist;American;American Cancer Society;Anemia;Animal Model;B-Lymphocytes;Bacteria;Blood;Blood Cell Count;Blood Cells;Blood coagulation;Blood Transfusion;blood treatment;cancer therapy;Carbon;Cell Count;Cell Lineage;cell type;Cells;Cessation of life;Chemicals;cost;Country;Data;Diagnosis;Dianisidine;Disease;disease model;Disease Progression;docosapentaenoic acid;Economic Burden;Economics;Embryo;Erythrocytes;Erythroid;Expenditure;Exposure to;Face;Fatty Acids;Fertilization;fluorescence imaging;Foundations;Genetic;Genetic Diseases;Goals;granulocyte;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hour;Human body;Immune system;Immunosuppression;In Situ Hybridization;in vivo;Infection;Inflammation;Intervention;Isomerism;L-Plastin;Lymphoid;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;meter;Microscopy;Modeling;Molecular;monocyte;MYB gene;Myelogenous;Natural Compound;neutrophil;novel;novel therapeutics;Omega-3 Fatty Acids;Oral;Outcome;palliating symptoms;Patients;Persons;Pharmaceutical Preparations;pi bond;Play;Polyunsaturated Fatty Acids;prevent;progenitor;Proliferating;Rag1 Mouse;receptor;Resolution;Role;sample fixation;screening;self-renewal;social;Stains;stem cell biomarkers;stem cell proliferation;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;Transgenic Organisms;Vertebrates;Visualization;Work;Zebrafish

PROJECT_TITLE: Roles of DPA derived specialized pre-resolving mediators during vertebrate hematopoiesis


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The malaria parasite causes a staggering global health burden, yet its key biological structures and processes remain understudied. To better understand parasite cell division, this proposal focuses on the proteins that comprise the cytokinesis-driving contractile ring. By investigating the role of three transmembrane proteins, the goal is to reveal novel insights into parasite-specific mechanisms of cytokinesis that can inform the next generation of antimalarial drugs.

PI_NAMEs: BACK, PETER S (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Anti-malarials;asexual;Atlases;Automobile Driving;Biochemical;Biogenesis;Biological;Biological Assay;Biology;Blood;Boston;career;Categories;Cell division;Cell membrane;Cell Nucleus;Cell Survival;Cells;Cessation of life;combinatorial;Communities;comparative;Complex;Cytokinesis;Data;daughter cell;Defect;Detergents;Development;Drug resistance;Ensure;Environment;Epitopes;Eukaryota;Eukaryotic Cell;Excision;experience;fitness;Flow Cytometry;Focus Groups;Future;Genetic Materials;Genetic Techniques;global health;Goals;Growth;Human;Immunofluorescence Immunologic;Individual;insight;Integral Membrane Protein;International;Knock-out;Knowledge;Life Cycle Stages;Link;live cell imaging;live cell microscopy;Location;Malaria;malaria infection;Mediating;meetings;Membrane;Mentors;Methods;Microbiology;Microscopy;Modeling;Molecular Biology;new therapeutic target;next generation;novel;novel therapeutics;Organelles;Parasites;Pediatric Hospitals;Peripheral;Phenotype;Plasmodium;Plasmodium falciparum;Positioning Attribute;Process;Proliferating;Property;protein complex;protein structure;Proteins;Research;Research Personnel;Resolution;Role;scaffold;Scientist;skills;sodium carbonate;Structure;Subgroup;superresolution microscopy;symposium;Symptoms;System;Technical Expertise;Techniques;Testing;Toxoplasma;Training;Transmembrane Domain;ultra high resolution;Visualization;Work

PROJECT_TITLE: Understanding the role of transmembrane proteins for Plasmodium cell division

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: Narrative This research aims to inform integration of mental health care within routine HIV services for adolescents and youth in Kenya. We will develop, pilot and cost implementation strategies for integrating assessments for common mental disorders among adolescents and youth with HIV ages 15 to 24 years, and effective referrals to specialists. Dr. Mugo seeks to build expertise in advanced implementation science methods, qualitative and mixed methods, stakeholder engagement, and skills in scientific leadership in order to transition to an independent research career that advances high quality mental health care for adolescents and youth with HIV.

PI_NAMEs: WACHIRA, CYRUS MUGO (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Administrator;Adolescent;Adopted;Affect;Africa South of the Sahara;Age;antiretroviral therapy;Anxiety;Career Mobility;Caregivers;Caring;Clinic;Collaborations;Competence;Complement;Complex;Computerized Medical Record;Consolidated Framework for Implementation Research;cost;Data;Depression screen;design;Disclosure;Disease;economic evaluation;Educational workshop;Epidemiology;Equity;Evaluation;Evidence based intervention;Family dynamics;Focus Groups;Frequencies;Goals;Health;health assessment;Health Information System;HIV;implementation barriers;implementation cost;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Interruption;Intervention;Interview;Kenya;Leadership;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;microcosting;novel;Patient-Focused Outcomes;Patients;Policies;Procedures;Professional counselor;programs;Provider;Psyche structure;Psychiatrist;Psychologist;Psychosocial Assessment and Care;Psychotherapy;Quasi-experiment;Questionnaires;Recommendation;Records;Reporting;Research;scale up;screening;Series;Services;skills;social stigma;Specialist;Specific qualifier value;Surveys;Symptoms;Techniques;telehealth;Testing;Time;Training;Trauma;treatment adherence;treatment guidelines;urban area;Viral;Viral Load result;Visit;Work;Workload;Youth

PROJECT_TITLE: Integration of Mental Health Services in HIV Care for Adolescents and Youth in Kenya

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


NIH_SPENDING_CATS: Neurosciences;Opioids

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative GPCRs are a large family of signaling receptors that mediate many biological functions, including analgesia in the context of the mu-opioid receptor. We recently identified the cholesterol sequestering protein, PTCHD1, as a negative regulator of the mu-opioid receptor. This project seeks to understand how PTCHD1 shapes the cellular response to opioids at a molecular level and will provide insights into the mechanisms by which membrane shaping proteins regulate GPCR signaling.

PI_NAMEs: LANKFORD, COLTEN KEITH (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Absence of pain sensation;Acute;Agonist;Analgesics;Attenuated;attenuation;Back;Binding;Binding Sites;Biological Assay;Biological Process;Biology;Cell Line;Cell membrane;Cells;Cholesterol;cholesterol-binding protein;clinically relevant;Cues;Data;Development;Environment;Epidemic;Erinaceidae;Exhibits;extracellular;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Screening;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Hormones;Impairment;insight;Knock-out;Knockout Mice;Lipids;live cell microscopy;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Membrane Proteins;methyl-beta-cyclodextrin;Molecular;Molecular Target;Monitor;mu opioid receptors;Mus;mutant;Neuromodulator Receptors;Neurons;Neurotransmitters;novel;opiate tolerance;Opioid;opioid abuse;Opioid Analgesics;Pain management;patched protein;Pathway interactions;Pharmaceutical Preparations;Phenocopy;Play;positive allosteric modulator;prevent;Process;protein activation;protein transport;Proteins;receptor;receptor function;receptor internalization;receptor recycling;receptor-mediated signaling;Recycling;Regulation;Research;response;Role;Route;Shapes;side effect;Signal Transduction;Sphingomyelins;Structure;Testing;trafficking;Translating;Transmembrane Domain

PROJECT_TITLE: Defining the mechanism of PTCHD1 and membrane cholesterol in the regulation of the mu-opioid receptor


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Palliative Care;Pediatric;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: NARRATIVE This research study will enhance understanding of how parental caregivers of adults with profound autism rate their quality of life and what factors most significantly impact their quality of life. Adults with profound autism require substantial, 24 hour-a-day, care. This study’s results can be used to identify policies, supports, resources, and interventions which improve parental caregivers’ lives, support them in their role, and help them provide quality care for their loved one.

PI_NAMEs: WELLINGTON, JESSICA  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adult;Adult Children;adult with autism spectrum disorder;aged;Aging;Area;autism spectrum disorder;autistic children;care recipients;career;career development;Caregiver Burden;caregiver quality of life;Caregiver support;Caregivers;caregiving;Caring;Child;Childhood;Communication;comorbidity;Complex;Data;Data Collection;Day Care;design;Developmental Disabilities;Diagnosis;Disabled Persons;economic value;Ensure;experience;Face;Family Caregiver;Family member;Financial Hardship;Future;Goals;Health;health related quality of life;Healthcare Systems;Hour;improved;improved outcome;Individual;individuals with autism spectrum disorder;Intervention;Interview;Knowledge;Life;Lived experience;Longevity;loved ones;Measures;Mental Depression;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality risk;Parents;peer;Personal Satisfaction;Persons;Policies;Population;Prevalence;profound autism;Qualitative Methods;Quality of Care;Quality of life;Reporting;Research;Research Design;Research Infrastructure;research study;Resources;Role;Science;Services;severe intellectual disability;skills;social determinants;social health determinants;Structure;Support System;Surveys;System;Training;United States;Work;Writing

PROJECT_TITLE: Examining the relationship between caregiving factors, social determinants of health, and quality of life among parental caregivers of adults with profound autism: A mixed methods study

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Significant disparities exist in prevalence, invasiveness and mortality in specific cancers and across multiple patient reported outcomes (PROs) including quality of life and symptom burden in Hispanic/Latinos (H/Ls) in the US. The proposed cohort study will contribute to our understanding of how multiple factors (e.g., social, cultural psychosocial, medical, biological) contribute to cancer survivors’ outcomes including symptoms, quality of life and mortality in a diverse sample of H/Ls regarding SES, H/L origin and geography. As cancer is the leading cause of death in Hispanic/Latinos—the largest minority population in the US that is expected to double in the next 40 years, the study will fill critical gaps in knowledge and provide much needed information to guide secondary and tertiary prevention efforts.

PI_NAMEs: PENEDO, FRANK J (contact);RAMIREZ, AMELIE G

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Acculturation;Address;Admixture;advanced disease;American;Area;Attention;Behavioral;Biological;Biological Assay;Biological Factors;Biological Process;Breast;Cancer Center;cancer genomics;cancer site;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer type;cardiometabolism;Catchment Area;Cause of Death;Cervix Uteri;Characteristics;Chronic stress;Clinics and Hospitals;Cognition;cohesion;cohort;Cohort Studies;Collaborations;Community Outreach;comorbidity;Comprehensive Cancer Center;Computational Biology;Conflict (Psychology);coping;Country;Cuban;cultural values;Data;data management;Disease;Disparity;Education;emotional functioning;Emotions;ethnic minority population;Ethnic Origin;experience;Family;Fatigue;Florida;follow-up;Gene Expression;Genetic;Geographic Distribution;Geographic Locations;Geography;Health;health determinants;health related quality of life;Health Services Accessibility;High Prevalence;Hispanic;Hispanic Populations;Individual;Inflammation;Inflammatory;Information Systems;Insurance Coverage;Knowledge;Language;Latino;Latino Population;Life Style;Literature;Liver;low socioeconomic status;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Mediator;Medical;Mental Depression;Methods;metropolitan;Mexican;Mexican Americans;Minority;Minority Groups;Modeling;mortality;National origin;NCI-Designated Cancer Center;neoplasm registry;Not Hispanic or Latino;nutrition;optimism;Outcome;Outcome Study;Pain;Participant;Pathway interactions;Patient Outcomes Assessments;perceived discrimination;Phase;Physical activity;Physical Function;Population;Prevalence;primary outcome;Procedures;Productivity;Prostate;Protocols documentation;psychosocial;Puerto Rican;Quality of life;recruit;Recurrence;Reporting;Research;resilience;Risk;Rural;rural residence;Sampling;satisfaction;Second Primary Cancers;Secondary Prevention;sex;Signal Transduction;Site;Sleep;social;social culture;Social Functioning;Social support;sociocultural determinant;Socioeconomic Status;South American;South Texas;Stomach;Stress;Survivors;survivorship;Symptom Burden;Symptoms;tertiary prevention;Testing;Texas;Training;traumatic stress;treatment adherence;Urban Community;Work

PROJECT_TITLE: Avanzando Caminos (Leading Pathways): The Hispanic/Latino Cancer Survivorship Cohort Study.”


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: The proposed research focuses on the implementation of uniform, multi-vendor acquisition, analysis and quality assurance methods for structural and functional magnetic resonance imaging methods that can be used as biomarkers of early therapeutic response. The proposed methods would lead to greater clinical trial efficiency enabling more rapid drug discovery and improved patient care.!

PI_NAMEs: STOKES, ASHLEY M (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;Adopted;Adoption;Affect;Aftercare;Agreement;Algorithmic Analysis;Algorithms;Architecture;automated algorithm;bevacizumab;Biological Markers;Biometry;Biopsy;Blood Vessels;Brain Neoplasms;Cellularity;cerebral blood volume;Characteristics;Clinical;Clinical Management;clinical practice;clinical translation;Clinical Trials;commercialization;Communities;Computer software;contrast enhanced;Contrast Media;conventional therapy;Data;Diagnosis;Dose;drug discovery;early detection biomarkers;Early identification;Ensure;Evaluation;Excision;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gadolinium;Glioma;Goals;Guidelines;Healthcare;healthy volunteer;Image;Image Analysis;imaging modality;improved;Industry Standard;Injections;Institution;Libraries;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measurement;Measures;Medical Care Costs;Meta-Analysis;Methodology;Methods;Morbidity - disease rate;mortality;MRI Scans;Multi-Institutional Clinical Trial;Multicenter Trials;neuro-oncology;novel;open source;Operative Surgical Procedures;Outcome;Oxygen;Patient Care;Patients;Performance;Perfusion;Permeability;personalized care;Phase;Physiologic pulse;Physiological;predictive tools;Predisposition;programs;prospective;Prospective cohort;Protocols documentation;Publishing;Pythons;quality assurance;quantitative imaging;radiation effect;Radiation therapy;Recurrence;Reporting;Reproducibility;Reproducibility of Results;Research;Resources;response;Scanning;Scheme;Site;Standardization;Structure;targeted treatment;Testing;The Cancer Imaging Archive;Time;tool;treatment planning;treatment response;tumor;tumor progression;user-friendly;Vendor

PROJECT_TITLE: Multi-parametric Perfusion MRI for Therapy Response Assessment in Brain Cancer


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Research Narrative Despite our understanding of immunology, numerous challenges exist in understanding disease transmission, pathology, and developing new vaccines against life-threatening infectious diseases. These include a limited understanding of immune correlates of protection, identification of viable vaccine candidates, and off- target effects that must be evaluated in staged clinical trials. This project will develop a hydrogel-based human immune organoid, inspired by lymphoid tissues, for generating antigen-specific GC B cells and examine in vivo engraftment of ex vivo engineered B cells.

PI_NAMEs: SINGH, ANKUR  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Adhesions;Adjuvant;Affinity;aging population;Animal Model;Antibodies;Antibody Affinity;Antigen Presentation;Antigens;Autoimmune Diseases;B cell therapy;B-Cell Activation;B-Cell Development;B-Lymphocytes;Binding;Biocompatible Materials;Biomedical Engineering;Bone Marrow;Cancer Patient;Cell Culture Techniques;cell growth;Cell Therapy;Cells;Characteristics;chemokine;chronic infection;Clinical;Clinical Trials;Coculture Techniques;Communicable Diseases;Complex;Cues;Data;Decision Making;demographics;disease transmission;Effectiveness;Elderly;Engineering;Engraftment;Epigenetic Process;epigenome;ethylene glycol;Exposure to;Extracellular Matrix;Funding;Future;Gel;Generations;Genetic Transcription;Goals;Homing;Human;Human Engineering;Humoral Immunities;Hydrogels;Immune;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin-Secreting Cells;Immunology;Impairment;In Vitro;in vivo;in vivo engraftment;Individual;Infection;Injectable;innovation;Kinetics;Label;Lead;Life;lymph nodes;Lymphoid;Lymphoid Tissue;Lymphoma;Maleimides;Mediating;Memory;Memory B-Lymphocyte;Microbe;Mus;Mutate;nonhuman primate;novel therapeutics;novel vaccines;Oral;Organoids;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Plasma Cells;pre-clinical research;Predisposition;Process;Proliferating;Reaction;reconstitution;Reporting;Research;response;Sampling;Slice;Source;Stromal Cells;Structure of germinal center of lymph node;subcutaneous;Surface;T-Lymphocyte;Technology;Tissues;Tonsil;transcriptome;Translating;Vaccination;vaccine candidate;Virus Diseases

PROJECT_TITLE: Hydrogel-based lymphoid tissues for generation of activated human B cells and delivery in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Animal venoms are a well-established source of bioactive molecules, which have been historically beneficial to human health through pharmacological drug discovery as well as harmful during snakebite envenomation. Few studies have investigated the metabolism and function of venom-associated microbes and their infectious and bioactive potential. This proposal combines field and laboratory studies with microbial multi-omic and molecular bioassay techniques to understand the breadth of bacterial diversity in snake venom, identify bioactive bacterially produced compounds, and elucidate their role in venom toxicity.

PI_NAMEs: LEV, KATHERINE LEAH (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Affect;Analytical Chemistry;Animals;Anti-Bacterial Agents;anti-cancer;anti-microbial peptide;Arizona;Bacteria;bacterial community;Binding;bioinformatics tool;Biological;Biological Assay;Blood coagulation;Cardiac;Categories;cathelicidin;Catheterization;Chemical Structure;Chemicals;Chemistry;Classification;Clinical;comparative;Complex;computer studies;design;DNA sequencing;drug development;drug discovery;Environment;FDA approved;field study;Future;Genome;genome sequencing;Genomics;Gland;Goals;Guidelines;Habitats;Health;Hematology;Human;Immune response;improved;Infection;Injury;interest;Investigation;Laboratory Study;Libraries;Life;Literature;Metabolic Pathway;Metabolism;metabolome;metabolomics;Metagenomics;Methods;Microbe;microbial;microbiome;microbiota;Mining;Modernization;Molecular;mortality risk;multiple omics;neglected tropical diseases;novel;Nutrient availability;Oral;Oral cavity;oral microbial community;oral microbiome;Organ;Pain management;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Physiological;Production;Property;Public Health;Reptiles;Research;response;Risk;Role;Sampling;screening;small molecule;Snake Bites;Snake Venoms;Snakes;Source;Sterility;Stress;Taxonomy;Techniques;Technology;Testing;Therapeutic Agents;Time;Toxic effect;Toxin;Venoms;World Health Organization;Wound Infection

PROJECT_TITLE: Viper-active: Snake Venom Microbiome as a Source for Bacterially-derived Molecule Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04A-V (20)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Liver disease is one of the highest causes of morbidity and mortality in the country, and by studying rare forms of liver disease evidence suggests we can better understand more common forms of disease. GIMAP5 is a protein that when mutated to cause a loss-of-function leads to dysfunction of the cells that compose blood vessels in the liver. By better understanding the mechanisms by which GIMAP5 causes blood vessel dysfunction, we can potentially discover novel treatments for patients with this rare disease as well as for more common forms of liver disease.

PI_NAMEs: BRANCALE, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Alleles;Ammonia;Architecture;Automobile Driving;Basement membrane;Biological Assay;Blood flow;Blood Vessels;Capillarity;CD34 gene;Cell Communication;cell dedifferentiation;Cells;Cessation of life;chronic liver disease;Cirrhosis;cohort;comparison control;conditional knockout;Confocal Microscopy;Country;Cre lox recombination system;Data;Data Set;design;Development;Diagnosis;Disease;Disease Progression;Drug Metabolic Detoxication;Electron Microscopy;Endothelial Cells;endothelial dysfunction;Endothelium;Etiology;exome sequencing;Family member;Flow Cytometry;Functional disorder;Gene Deletion;Gene Expression Profile;Genes;Genetic;Genetic Diseases;global health;Gluconeogenesis;Goals;GTPase Gene;Guanosine Triphosphate Phosphohydrolases;Hematopoietic;Hepatic;Hepatocyte;Histopathology;Homeostasis;Human;Immune;Impairment;in vivo;Individual;inducible Cre;interest;Knock-out;knockout gene;Knockout Mice;Knowledge;Laboratories;Life;Ligands;Liver;Liver diseases;Liver Dysfunction;Liver parenchyma;liver transplantation;loss of function;loss of function mutation;Maintenance;Mediating;Metabolic;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;Mutation;new therapeutic target;novel;novel therapeutic intervention;Organ;Organ Donor;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physicians;Portal Hypertension;Portal vein structure;prevent;Process;Proteins;Rare Diseases;Regulation;Reporter;Resistance;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Training;Transcription Alteration;Visualization;WNT Signaling Pathway;Work;Xenobiotic Metabolism

PROJECT_TITLE: Investigating the role of endothelial Gimap5 in maintaining liver homeostasis

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Congenital heart disease (CHD), the most common human birth defect, occurs in ~1% of live births and has a genetic cause in almost 45% cases. Genetic variants of unknown significance may contribute to unexplained CHD. We will study these variants to determine their functional impact on cardiac cells.

PI_NAMEs: PU, WILLIAM TSWENCHING;SEIDMAN, CHRISTINE E (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Affect;Alleles;Aneuploidy;Benign;Biological Assay;Biological Process;Cardiac;cardiogenesis;Cardiovascular system;Cell Line;Cells;Childhood;chromatin modification;Classification;clinical outcome assessment;Code;cohort;Congenital Abnormality;congenital heart abnormality;Copy Number Polymorphism;Counseling;Data;de novo mutation;deep learning model;defined contribution;Developmental Gene;Diagnosis;Disease;Enhancers;Etiology;exome;exome sequencing;Family;Gene Expression;Gene Expression Regulation;gene function;General Population;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genome;genome sequencing;Genotype;Human;improved;induced pluripotent stem cell;Inherited;insight;Knock-in;Knowledge;Learning;Live Birth;loss of function;Machine Learning;model building;Molecular;Mus;Mutagenesis;Nature;Newborn Infant;non-genetic;Organ;Pathogenicity;Patients;pediatric patients;Phenotype;predictive modeling;proband;protein structure;Proteins;rare variant;Recurrence;Regulatory Element;Reporter;Risk;RNA Splicing;single nucleus RNA-sequencing;Site;spatiotemporal;Syndrome;synthetic biology;Testing;Translations;Untranslated RNA;Variant;variant of unknown significance;Work

PROJECT_TITLE: Identifying unrecognized genetic causes of congenital heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: OMAHA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Narrative The vestibular system is a primary contributor to balance and mobility. A loss of vestibular sensory function in both ears (i.e., bilateral vestibular hypofunction) yields a substantial increase in fall risk and a considerable reduction in health-related quality of life. This project aims to address the disproportionate health-related burden of this condition by developing a novel strategy for improving vestibular function in individuals diagnosed with bilateral vestibular hypofunction.

PI_NAMEs: WAGNER, ANDREW RAYMOND (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Age;Alternative Therapies;Animal Model;Automobile Driving;Balance training;Behavior;Bilateral;career;career development;clinical development;Clinical Trials;Cues;Data;desensitization;design;Development Plans;Diagnosis;Dizziness;Doctor of Philosophy;Ear;environmental change;Equilibrium;Esthesia;Exposure to;Face;fall risk;falls;Future;gaze;Goals;Head Movements;Health;Health Expenditures;health related quality of life;Hour;improved;improved outcome;Individual;innovation;Institution;Intervention;Knowledge;Lead;Learning;Lesion;Measures;Mentors;Mentorship;Methods;Monitor;Motion;Movement;Nature;Nervous System;neural;Neuronal Plasticity;Neurons;neurophysiology;novel;novel strategies;Ohio;Outcome;Pathology;Patient Self-Report;Patients;Performance;Personal Satisfaction;Phase;Protocols documentation;Quality of life;recruit;rehabilitation science;rehabilitation strategy;Rehabilitation therapy;Research;Research Project Grants;response;Rotation;Sampling;Scientist;Secondary to;Sensory;sensory stimulus;Series;skills;Stimulus;Symptoms;System;Techniques;Training;Translations;Universities;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular Function Tests;Vestibular loss;vestibular system;vestibulo-ocular reflex;Vision;Work

PROJECT_TITLE: Subthreshold vestibular stimulation as a strategy for rehabilitation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative This project will investigate a novel murine model of congenital aortic valve disease with the objective of defining the cellular and molecular alterations associated with disease development and progression. This increased molecular understanding will be utilized to identify and test novel pharmacologic targets to prevent or slow aortic valve disease.

PI_NAMEs: GARG, VIDU  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Aging;aortic valve;aortic valve disorder;Aortic Valve Stenosis;bicuspid aortic valve;Birth;Cardiac;Cardiovascular system;Catheters;Cell Lineage;cell type;clinically relevant;congenital heart abnormality;Congenital Heart Defects;Development;Disease;Disease Progression;Embryo;Embryonic Development;Embryonic Heart;FDA approved;Genetic;Genomic approach;Goals;Heart failure;Heart Valves;Human;human disease;Integrins;Intervention;Knockout Mice;Knowledge;Lead;Left Ventricular Hypertrophy;Link;malformation;Medical;Membrane;Mitral Valve;Modeling;Molecular;Morphogenesis;Morphology;mouse model;multiple omics;Mus;mutant mouse model;Mutant Strains Mice;Nature;Neonatal;neonatal mice;Nitric Oxide;Nitric Oxide Synthase;NOS3 gene;notch protein;NOTCH1 gene;novel;novel therapeutics;Operative Surgical Procedures;palliative;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Penetrance;Pharmaceutical Preparations;pharmacologic;Population;Prevalence;prevent;Progressive Disease;Publications;Pulmonary valve structure;receptor;Research;Role;Severities;Signal Pathway;Signal Transduction;Stenosis;Testing;Therapeutic;Thinness;transcription factor;Translational Research;United States;Up-Regulation;valve replacement;Variant;Ventricular Remodeling;WNT Signaling Pathway;Work;Zinc Fingers

PROJECT_TITLE: Mechanisms and Therapeutics for Congenital Aortic Valve Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-S (02)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Sleep Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE  Through my project a better understanding of the deep brain contributions to sleep-wake states will be gleaned, which will be beneficial to the future study of disordered sleep-wake states, such as in sleep disorders or other disorders where sleep is altered like in Alzheimer’s Disease. Additionally, the high spatial resolution fMRI sequence at 7T, coupled with EEG, systemic physiology, and behavior, will establish an improved experimental setup for obtaining spatially precise functional data from small deep brain regions while simultaneously collecting electrophysiological, physiological, and behavioral data.

PI_NAMEs: CICERO, NICHOLAS GREGORY (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Alzheimer's Disease;Arousal;basal forebrain;Behavior;Behavioral;behavioral response;biomedical imaging;Boston;Brain;brain circuitry;brain control;brain health;Brain region;Brain Stem;Cell Nucleus;cholinergic;Clinical;Cognition;Coupled;Data;Dimensions;Dorsal;Electroencephalography;Electronics;Electrophysiology (science);extrastriate visual cortex;Eye;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Glean;Goals;Hour;Human;Human Resources;human subject;improved;Individual;innovation;Knowledge;Laboratory Research;Light;light intensity;Link;locus ceruleus structure;magnetic field;Magnetic Resonance Imaging;Maintenance;Mammals;Massachusetts;Measurement;Mentors;Moods;multimodality;Nervous System Disorder;neural;neuroimaging;neuromechanism;Neuromodulator;neuroregulation;Neurosciences;non rapid eye movement;Patients;Pattern;Physiological;Physiology;Positioning Attribute;programs;Property;rapid eye movement;REM Sleep;Research;Research Training;Resolution;response;Rest;Rodent;Role;Scanning;Sensory;sensory stimulus;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep regulation;Sleep Wake Cycle;spatiotemporal;Stereotyping;Stimulus;Structure;support network;System;Techniques;Technology;temporal measurement;Testing;Universities;visual processing;visual stimulus;wasting;Work

PROJECT_TITLE: Ascending Arousal Network Control of Sleep-Wake Structure in Humans Using Simultaneous EEG and High-Resolution fMRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Social Determinants of Health

PHR: Project Narrative Adverse childhood experiences (ACEs) exert a significant, detrimental impact on adult health outcomes, while positive childhood experiences (PCEs) have been shown to have a protective effect, even in the presence of ACEs. Less is known, however, about the specific mechanisms of intergenerational transmission of parental ACEs and PCEs to their children’s ACEs and the impact on parenting practices. The results of the proposed study will provide additional insight on parental transmission of both positive and adverse childhood experiences, parenting practices, and opportunities to translate findings into community interventions.

PI_NAMEs: DRENTH, PATRICIA JILL-KELLY (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Adult;adverse childhood events;Attention;Buffers;Cessation of life;Child;Child Rearing;Childhood;community intervention;Data;Data Analyses;Data Collection;Data Set;design;Development;Diabetes Mellitus;Dose;Enrollment;Environment;evidence base;experience;Family;Fellowship;Foundations;Future;Generations;Goals;Health;Health Promotion;high risk;high risk population;Home visitation;Household;Individual;Individual National Research Service Award;insight;intergenerational;Interruption;Intervention;Learning;lens;Measurement;Mediating;Medicine;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;Michigan;National Institute of Nursing Research;neglect;next generation;nursing intervention;Obesity;Outcome;panel study of income dynamics;Parents;Pathway interactions;Pediatrics;Perception;pre-doctoral;Prevention;programs;protective effect;Public Health;Public Health Nursing;Publishing;Recommendation;Research;Research Design;Research Project Grants;research study;response;Risk;Role;School Nursing;Scientist;Secure;Shapes;Solid;stem;Strategic Planning;substance use;System;Training;Translating;transmission process;Trauma;Universities;Violence;Well in self

PROJECT_TITLE: Positive Childhood Experiences and Intergenerational Trauma Transmission


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to unravel the intricacies of imprinted gene regulation through the investigation of chromatin organizations. By focusing on neuron-specific imprinted genes, the results will elucidate the molecular mechanisms and physiological functions of imprinted genes in the brain. The insights gained from this research will enhance our understanding of human imprinting disorders and related neuropathological conditions.

PI_NAMEs: BAE, BONG MIN  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Alleles;associated symptom;atmospheric sciences;Biogenesis;Brain;ChIP-seq;Chromatin;Chromatin Structure;Chromosome 6;Chromosome 7;Coatomer Protein;Collaborations;Coupled;CRISPR interference;Data;Defect;Deposition;Development;Disease;DNA Methylation;dosage;Enhancers;Environment;Epigenetic Process;epigenetic regulation;Etiology;Exhibits;experimental study;Gene Expression Regulation;Gene Order;Genes;Genomic Imprinting;Growth;Hi-C;Homeostasis;Human;Human Chromosomes;human disease;Hybrids;imprint;insight;Investigation;Light;Link;lipid metabolism;Lipids;Maps;Maternal Behavior;Mediating;Metabolism;Modeling;Molecular;Mus;Mutation;Nervous System;neurodevelopment;Neurologic;Neurons;neuropathology;novel;Orthologous Gene;Outcome;Parents;Pattern;Physiological;Play;Positioning Attribute;postnatal;postnatal development;prenatal;promoter;protein complex;Proteins;Publishing;Regulation;Regulatory Element;Reporting;Research;Research Personnel;Role;scientific atmosphere;Sequence Deletion;Shapes;Silver-Russell syndrome;skills;stem;Structure;Testing;tool;training opportunity;Transportation;Universities;Vesicle

PROJECT_TITLE: Role of Chromatin Structures in Genomic Imprinting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  While there are over 483,000 childhood cancer survivors in the United States and that number is increasing, only about a third of these individuals receive age-appropriate survivorship care. Without adequate psychosocial support, symptoms of posttraumatic stress may increase risk of not receiving guideline-based follow-up care, especially among young adults who are already at risk for getting "lost in transition" from pediatric to adult health care. To address calls from the NCI, this study seeks to target survivorship transition and healthy lifestyle engagement in survivors by investigating posttraumatic growth (PTG) as a potential modifiable factor that may be linked to positive health outcomes among pediatric cancer survivors.

PI_NAMEs: GILBERT, RENEE M (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Adherence;Adult;Age;anti-cancer research;Behavior;Behavioral;behavioral health intervention;Cancer Intervention;Cancer Relapse;Cancer Survivor;Cancer Survivorship;Caring;Characteristics;Child;Childhood;childhood cancer survivor;Cities;Clinic;clinical care;Consent;Databases;design;Development;Diet;dietary;dietary guidelines;Eating;ethnic minority;Exercise;experience;Feeling;follow-up;functional improvement;Goals;good diet;Growth;Guidelines;Health;Health behavior;health equity;Healthcare;healthy lifestyle;improved;Individual;Infertility;Intervention;Interview;Kansas;Knowledge;Late Effects;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Medical center;medical specialties;Methods;moderate-to-vigorous physical activity;novel;Obesity;Outcome;Participant;patient engagement;Patients;Pediatric cohort;Physical activity;post-traumatic symptoms;Posttraumatic growth;Prevention;Provider;psychologic;Psychosocial Assessment and Care;Psychosocial Factor;racial minority;Recommendation;recruit;Recurrence;Registries;Research;Research Project Grants;Research Training;Risk;Role;rural area;Second Primary Cancers;skills;Strenuous Exercise;Stress;stressor;Structure;Survivors;survivorship;Techniques;Testing;Therapeutic;therapy development;Time;Training;Translational Research;translational scientist;Trauma;traumatic event;Underrepresented Populations;United States;Universities;young adult

PROJECT_TITLE: Transition and Health Implications of Posttraumatic Growth in Pediatric Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Declining cognitive flexibility is a debilitating symptom of aging and several neurodegenerative diseases that affects individuals’ independence, socialization, and ability to adapt to the changing world around them, placing the burden of care on loved ones, caregivers, and medical professionals. Despite its prevalence, there are currently no prevention or therapeutic strategies for treating impairments in cognitive flexibilities. I propose that a mechanistic understanding of the neural circuits governing cognitive flexibility and a molecular model describing the structural regulation of these circuits may result in the discovery of new therapeutic strategies to ensure independence in our aging population.

PI_NAMEs: ROZEMA, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acceleration;Adult;Affect;age related;Aging;aging brain;aging population;aging process;Architecture;Behavior;biological adaptation to stress;Brain;Brain region;care burden;Caregivers;Cellular Stress;Characteristics;ChIP-seq;Cognition;Cognitive;cognitive ability;cognitive change;cognitive control;Cognitive deficits;cognitive function;cognitive reappraisal;Communication;Complex;Corpus striatum structure;debilitating symptom;density;differential expression;Discrimination;Discrimination Learning;Dorsal;Down-Regulation;Elderly;Ensure;Enterobacteria phage P1 Cre recombinase;Environment;Event;Excitatory Synapse;executive function;experimental study;flexibility;Fluorescence;Functional disorder;functional independence;Functional Magnetic Resonance Imaging;Genes;Genetic Transcription;glutamatergic signaling;Glutamates;Goals;heat shock transcription factor;Hippocampus;Human;Impaired cognition;Impairment;improved;in vivo;Individual;Knockout Mice;Knowledge;Label;Learning;Light;loved ones;Maintenance;Mass Spectrum Analysis;Mediating;Medical;Memory;Molecular;molecular modeling;motor control;Mus;Nerve Degeneration;nerve supply;Neurabin;neural circuit;Neurodegenerative Disorders;normal aging;novel therapeutic intervention;older adult;Older Population;optogenetics;Pathway interactions;Performance;Phase;Positron-Emission Tomography;postsynaptic;Presynaptic Terminals;Prevalence;prevent;Prevention;Process;Proteins;Proteomics;proteostasis;Regulation;restoration;Reversal Learning;Role;Signal Transduction;Socialization;Sorting;Synapses;Synaptophysin;Synaptosomes;targeted treatment;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;Thinking;transcription factor;transcriptome sequencing;visual discrimination;Work

PROJECT_TITLE: Molecular and functional implications of thalamo-striatal synapse regulation in learning and memory


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Socioeconomic and psychosocial factors are known to increase risk of CVD, but the mechanisms are not fully clear. Premature aging resulting from chronic stress may be one pathway. This study will examine whether identity characteristics influence susceptibility or resilience to premature aging under stress.

PI_NAMEs: BEY, GANGA SARASVATI (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Active Learning;Address;Age;age group;Aging;aging process;aging related;Atherosclerosis Risk in Communities;Behavior;Belief;biological age;Biological Aging;black women;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;career;Characteristics;Chronic;Chronic Disease;Chronic stress;Chronology;Clinical;cohort;Communities;Competence;coping;Data;Development;Dimensions;disease disparity;Disparity;Disparity population;DNA Methylation;DNA Modification Process;environmental stressor;epigenetic aging;epigenetic clock;Epigenetic Process;Ethnic Origin;Foundations;Future;Gender;gender disparity;Gender Identity;Geroscience;Goals;Grant;Health;Health behavior;health disparity populations;healthy aging;Heart failure;Individual;Inequity;innovation;Investigation;Jackson Heart Study;Knowledge;Lead;Learning;lens;Literature;Measurement;Measures;Mediating;men;Mentorship;Modeling;mortality;negative affect;novel;optimism;participant enrollment;pathological aging;Pathology;Pathway interactions;Phase;Play;Positioning Attribute;Predictive Factor;Predisposition;Premature aging syndrome;prevent;Property;Prospective cohort;Psychological Factors;Psychometrics;psychosocial;Psychosocial Factor;Psychosocial Influences;psychosocial stressors;Public Health;Race;racial disparity;Religiosity;Research;resilience;resilience factor;Risk;Risk Factors;Role;Sampling;Self Concept;Severities;skills;social;social adversity;Social Conditions;social disparities;Social Environment;social group;Social Sciences;Social status;social stressor;Socioeconomic Factors;socioeconomics;Source;Spirituality;Stress;Stress and Coping;stressor;Testing;theories;Training;trait;Validation;White Women;Work;Writing

PROJECT_TITLE: Identity influences on psychosocial traits, biologic age, and cardiovascular disease disparities


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Survival and adaptation to genotoxic environments rely on complex and highly conserved molecular strategies, which when defective can cause genome instability syndromes and cancer. This work will investigate (1) how cells adapt to environmental genotoxin exposure by modulating DNA repair pathway choices via sumoylation; and (2) RPA downregulation and its impacts on DNA damage checkpoint recovery. This work will lay the foundation for elucidating cellular adaptation strategies and can inform disease prevention and potential therapeutic targets.

PI_NAMEs: CHWAT-EDELSTEIN, TZIPPORA  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;arm;ATR gene;Binding;Biological Assay;career;Cell Cycle;Cell Cycle Arrest;cell growth;Cells;Collaborations;Complex;coping;Coping Skills;Data;Defect;Development;Disease;disorder prevention;DNA Binding;DNA damage checkpoint;DNA lesion;DNA Repair;DNA Repair Pathway;Doctor of Philosophy;Down-Regulation;Environment;Enzymes;Equilibrium;Exposure to;Face;Foundations;Genetic;Genome;Genomic Instability;Genomics;Genotoxic Stress;genotoxicity;Goals;homologous recombination;Human;insight;Knowledge;Laboratory Finding;Lesion;Literature;Maintenance;Malignant Neoplasms;Mediator;model organism;Molecular;Monitor;Mutagens;Mutate;Mutation;Outcome;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;pollutant;Post-Translational Protein Processing;Prevention strategy;Process;Proteins;Proteome;Radiation;recombinational repair;Recovery;recruit;Regulation;repaired;Research;Research Personnel;response;Role;Saccharomycetales;sensor;Single-Stranded DNA;Site;Sumoylation Pathway;Syndrome;System;Testing;therapeutic target;tool;Training;treatment strategy;tumorigenesis;Ubiquitin;Ubiquitination;Work;Yeasts

PROJECT_TITLE: Protein Modification and Stability Regulation to Cope with Genotoxic Environments


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Considering the deadly nature of Ebola virus (EBOV), it is important to understand how different EBOV proteins contribute to viral replication. Focusing on the EBOV viral protein 24 (VP24), this project will examine the significance of VP24 interactions with different host proteins during EBOV replication. These studies will further our understanding about the role of VP24 in the EBOV life cycle and provide crucial information about cellular processes that could be targets for anti-EBOV therapeutics.

PI_NAMEs: VOGEL, OLIVIA ASHLEY (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Affinity Chromatography;alpha Karyopherins;ATP1A1 gene;Attenuated;Binding;Biological Assay;Biological Models;Biophysics;career;Carrier Proteins;Cell Nucleus;Cell Physiology;Cells;Characteristics;Co-Immunoprecipitations;Collaborations;Containment;Data;Disease Outbreaks;Ebola;Ebola virus;emerin;Ensure;Epitopes;experimental study;Family;Filovirus;Gene Expression;Genes;Genetic Transcription;Genome;Goals;Impairment;Infection;inhibitor;insight;interest;Interferon Suppression;Interferons;knock-down;Knock-out;Letters;Life Cycle Stages;Mass Spectrum Analysis;Mediating;member;Minor;Modeling;Molecular;mutant;Mutation;Nature;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Localization Signal;Nucleocapsid;nucleocytoplasmic transport;Ouabain;overexpression;particle;prevent;Production;protein protein interaction;Proteins;Proteomics;Publishing;Reporting;RNA Viruses;Role;Signal Transduction;Site;STAT1 gene;structural biology;Structure;System;Tertiary Protein Structure;Testing;Therapeutic;tool;trafficking;Training;Translations;Viral;Viral Proteins;Virus;virus host interaction;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Functional significance and mechanisms of Ebola Virus VP24-host protein interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


PHR: PROJECT NARRATIVE: The first-row transition metals (Fe, Co, Ni, Cu) offer great potential as earth abundant, inexpensive, and environmentally benign catalysts for the construction of C–C and C–heteroatom bonds in biologically active molecules; however, the instability of their active forms makes the discovery, optimization, and application of base metal-catalyzed reactions extremely challenging. The proposed research seeks to address these challenges by developing general, bench-stable base pre-catalysts that facilitate the use of these metals in the synthesis or bioactive scaffolds. Synthetic routes to these pre-catalysts will be designed and tested, then the novel pre-catalysts will be benchmarked in the well-known Suzuki Miyaura cross-coupling reaction and applied to challenging C–C and C–heteroatom coupling reactions that are unique to each of the metals of interest.

PI_NAMEs: THEDFORD, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Development of Base Metal Pre-catalysts for Applications in Catalytic Reaction Discovery


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Over the course of aging, many older adults show declines in balance control, limiting their normal daily function and increasing their risk of falling. In this project, we aim to understand how blood flow to the brain may contribute to brain processes that control balance in older adults and in individuals across the adult lifespan. Understanding the factors that influence brain processes for balance control with aging will help us to develop treatments that promote positive changes in the brain to reduce falling and maximize the independence of older adults.

PI_NAMEs: PALMER, JACQUELINE A (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acute;Adult;Aerobic Exercise;Age;age related;age related decline;Aging;aging brain;aging process;Alleles;Alzheimer's Disease;Alzheimer's disease risk;apolipoprotein E-4;Attenuated;Behavior;Blood flow;Blood Flow Velocity;Brain;brain dysfunction;brain health;Cardiovascular system;Career Choice;carrier status;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;Cerebrovascular system;Clinical;clinical training;clinical translation;Cognitive;cognitive function;cognitive load;daily functioning;Dementia;design;Development;disability;Early Diagnosis;early onset;Electroencephalography;Equilibrium;executive function;Exercise;Fall prevention;fall risk;falls;Fellowship;Foundations;Genetic;genetic risk factor;Genotype;Goals;high risk;human old age (65+);Impaired cognition;Impaired health;Impairment;Individual;innovation;insight;Knowledge;Laboratories;life span;Link;Maintenance;Measures;Mediating;Mentors;Methods;middle age;Mobility decline;Motor;multimodality;Nervous System;Nervous System Physiology;neuropathology;neurophysiology;neuroprotection;normal aging;older adult;Performance;Physical activity;Physical therapy;Physiological;Population;Positioning Attribute;post stroke;pre-clinical;precision medicine;preservation;Prevention;Process;Reaction;Regulation;Research Training;Resources;response;Rest;Science;skills;Stress;Task Performances;Testing;Training;Transcranial Doppler Ultrasonography;Translational Research;Walking

PROJECT_TITLE: Investigating cerebrovascular regulation during exercise as a factor influencing cortical resource engagement for balance control with aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE It is becoming increasingly accepted that gametes transfer non-genetic information from parent to child that modulate inherited phenotypes. A species of non-coding RNA, microRNAs, delivered from sperm to egg during fertilization have been demonstrated to causally induce changes in early development ultimately leading to non-genetically altered adult phenotypes; however, the molecular mechanisms underlying this phenomenon are unknown. In this project, I will determine the initial functions of sperm microRNAs in regulating early development and uncover the molecular mechanism underlying the paternal transfer of non-genetic information in mammals.

PI_NAMEs: LEE, GRACE SUNEUY (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Adult;Attention;Back;Base Pairing;Characteristics;Chemicals;Child;Complementary RNA;Computer Analysis;Cytoplasm;Data;Data Set;Development;Diet;Digestion;Double-Stranded RNA;Down-Regulation;egg;Embryo;Embryonic Development;Enzymes;Exhibits;experimental study;Exposure to;Fertilization;Gene Expression;Gene Expression Regulation;gene repression;Genes;Germ Cells;Individual;Inherited;insight;Literature;male;Mammals;Messenger RNA;Microinjections;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Molecular Mechanisms of Action;Mus;non-genetic;novel;Nucleotides;offspring;Oocytes;Pancreatic ribonuclease;Parents;Phenotype;Play;posttranscriptional;Pre-implantation Embryo Development;preimplantation;Proteins;Repression;reproductive tract;Ribonucleases;RNA;Role;Series;Small RNA;sperm cell;sperm function;stem;Stress;Structure;System;Testing;Toxin;Transcript;transcriptome;transcriptome sequencing;Translational Repression;transmission process;Untranslated RNA;zygote

PROJECT_TITLE: Determining the role of sperm microRNAs in early development and non-genetic inheritance


NIH_SPENDING_CATS: Aging;Back Pain;Chronic Pain;Pain Research

ORG_DEPT: ORTHOPEDICS

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE The ORS PSRS are holding the 7th International Spine Research Symposium on November 10-14, 2024 at Skytop Lodge, PA. The conference will disseminate state-of-the-art research, enhance scientific discourse, and promote collaborations in the field of intervertebral disc biology and pathogenesis as it relates to spine health, aging, and degeneration. We will convene a diverse group of spine experts of varying expertise and career stages to promote the advancement of basic, translational, and clinical science as it relates to disc aging and back pain.

PI_NAMEs: RISBUD, MAKARAND V (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academia;Address;Aging;Area;Back Pain;Basic Science;Biological Response Modifier Therapy;Biology;Biomechanics;Biomedical Engineering;career;Cellular biology;chronic pain;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;Dedications;Delaware;design;Development;Developmental Biology;Device Designs;Diagnosis;Discipline;discogenic pain;Disease;Ensure;Epidemiology;European;Faculty;Fees;Fostering;Funding;Goals;graduate student;Health;Image;improved;Industry;informal atmosphere;Injury;Institution;interest;International;Intervertebral disc structure;intervertebral disk degeneration;Knowledge;lectures;Location;Mechanics;meetings;minimally invasive;minority trainee;Modality;Molecular;Molecular Biology;Natural regeneration;Neck Pain;New York;Operative Surgical Procedures;opioid use;Organism;Orthopedics;Outcome;Pain;Paper;Participant;Pathogenesis;Pathology;Peer Review;Pennsylvania;Philadelphia;Postdoctoral Fellow;posters;Private Sector;Process;rapid growth;Rehabilitation therapy;Relaxation;Reporting;Research;Research Personnel;Scientist;Societies;Special Hospitals;Spinal Diseases;Stimulus;Students;symposium;Technology;Time;Tissue Engineering;Tissues;Training;training opportunity;translational physician;Translational Research;Translations;treatment strategy;Underrepresented Minority;United States National Institutes of Health;Universities;Update;Vertebral column;virtual reality;Woman;Work

PROJECT_TITLE: 2024 ORS/PSRS 7th International Spine Research Symposium

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]