ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: UROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Through the development of novel technological platforms for urothelium, the epithelial lining of the urinary bladder, this proposal intends to significantly enhance the ability of investigators in the field to interrogate the functions of genes that are important for regulating the growth, differentiation, proliferation and diseases of the urothelium.

PI_NAMEs: WU, XUE-RU  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acceleration;Adenoviruses;Adult;Area;Asparagine;Basal Cell;Biology;Biomedical Engineering;Bladder;Bladder Urothelium;Cell Compartmentation;Chemicals;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;cost;cost effective;Coupled;Cytokeratin;Cytoplasm;Cytoplasmic Tail;Cytoskeleton;Development;Diagnosis;Differentiation and Growth;Disease;Effectiveness;Elasticity;Electrodes;Electroporation;ENG gene;Engineered Gene;Epithelium;Escherichia coli;experimental study;Exposure to;feasibility testing;Funding Opportunities;gene function;Gene Mutation;Generations;Genes;Genetic;Genetically Engineered Mouse;genome editing;Glutamine;glycosylation;Goals;Growth;Guide RNA;Hematological Disease;human disease;in vivo;Infection;Inflammation;Injury;interest;intravesical;Kidney Diseases;Knock-out;knockout gene;Laboratories;LoxP-flanked allele;Mannose;Membrane;Methodology;Modeling;Molecular;Monitor;Mucous Membrane;Mus;Mutate;National Institute of Diabetes and Digestive and Kidney Diseases;Needles;new technology;novel;overexpression;Pathogenesis;Permeability;Plasmids;Point Mutation;PPARG gene;Principal Investigator;Procedures;Proliferating;protein biomarkers;Radiation induced damage;Reagent;receptor;Renal pelvis;Research;Research Personnel;response;Role;Site;Specificity;stem cells;success;Surface;System;Technology;technology development;technology platform;Testing;Tight Junctions;Time;Tissues;tool;tool development;transcription factor;ultrasound;UPK2 gene;UPK3 gene;Ureter;Urethra;Urethral Catheterization;Urinary tract;Urination;Urine;Urologic Diseases;Urothelial Cell;Urothelium;Wild Type Mouse

PROJECT_TITLE: Intravesical genome editing in urothelium

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Rural Health

ORG_CITY: LITTLE ROCK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Despite significant clinical and research advances in the field of food allergy, many remaining questions must be addressed before global implementation of impactful therapeutic and prevention options for patients affected by food allergy can be realized. The Arkansas Center for Food Allergy Research (ArCOFAR) builds on a >30 year foundation of expertise, and leadership in food allergy and is ideally positioned to function as a Clinical Research Center within the Consortium for Food Allergy Research. We will contribute our extensive research experience and capitalize on our population’s distinct geographic and patient demographic characteristics to immediately address the overarching program goal of the Consortium for Food Allergy Research to improve the health of children and adults living with food allergy and related disorders.

PI_NAMEs: JONES, STACIE M (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Achievement;Address;Adult;Advanced Development;Advocacy;Affect;Allergic;Allergy to peanuts;Area;Arkansas;Biological Markers;career;career development;Caring;Characteristics;Child;Child Health;Clinical;clinical care;Clinical Research;Clinical Skills;clinical translation;Clinical Trials;Collaborations;design;Development;Disease;Education;Effectiveness;Enrollment;Ensure;Eosinophilic Gastrointestinal Disease;ethnic diversity;Evaluation;experience;Faculty Recruitment;FDA approved;Food;food allergen;Food Hypersensitivity;food science;Foundations;Funding;Future;Geographic Locations;Geography;Goals;high school degree;Hypersensitivity;Immunotherapeutic agent;improved;Individual;Industry;innovation;International;Intervention;Investigation;Knowledge;Leadership;Life;Link;Locales;Longitudinal Studies;Low income;Measurable;medically underserved;Mentors;metabolomics;Mission;Modality;National Institute of Allergy and Infectious Disease;Natural History;next generation;novel;novel strategies;nutrition;Outcome;Participant;Patients;Peptides;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Prevention;Prevention strategy;Privatization;Productivity;programs;Race;racial diversity;Reaction;recruit;Research;Research Design;Research Personnel;response;response biomarker;Rural;Seminal;Shapes;Site;success;Testing;Therapeutic;Therapeutic Trials;therapeutically effective;Training;Translational Research;translational scientist;Translations;treatment response;treatment strategy;Underrepresented Minority;underserved area;Underserved Population;United States National Institutes of Health;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (J2)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Hydrocephalus;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative The proposed project will investigate how choroid plexus epithelial cells might sense and respond to changes in intracranial pressure (ICP). The results of this project will deepen our understanding of how the brain is able to dynamically balance blood, brain, and cerebrospinal fluid (CSF) volumes to regulate ICP, which can be pathologically elevated after traumatic brain injury, stroke, hemorrhage, tumor, hydrocephalus, and during seizures. The data collected in the proposed experiments could help inform therapeutic strategies for stabilizing ICP across several neurological conditions.

PI_NAMEs: PROFACI, CATERINA P (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Apical;Bathing;Blood;Blood Volume;Brain;brain volume;Calcium;Cations;cell type;Cells;Central Nervous System;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid clearance;cerebrospinal fluid flow;Cessation of life;Choroid Plexus Epithelium;clinically relevant;comparison control;Compensation;conditional knockout;Coupled;Data;Disease;Dose;Electrophysiology (science);Epithelial Cells;Equilibrium;Esthesia;Etiology;Exhibits;experimental study;Goals;Headache;Health;Hemorrhage;Hydrocephalus;Hydrostatic Pressure;Hyperactivity;Image;in vivo;Induced Neurons;Infusion procedures;Intracranial Hypertension;Intracranial Pressure;Intraventricular;Ion Channel;Ions;Kainic Acid;Knock-out;Knowledge;Liquid substance;Measurement;Measures;mechanical stimulus;Mechanoreceptors;mechanotransduction;Mediating;Membrane;Migraine;Modeling;Mus;Nervous System Disorder;Nervous System Trauma;neural;Neurologic;Neurons;neuropathology;Normal Range;Output;overexpression;Pathologic;Pathway interactions;Phenotype;Phosphorylation;Physiologic intraventricular pressure;Piezo 1 ion channel;Play;Positioning Attribute;Predisposition;pressure;Primary Cell Cultures;Process;Production;Regulation;response;Role;Seizures;Series;Severities;Signal Transduction;Source;Spinal Cord;Stimulus;Stroke;Structure;Structure of choroid plexus;Testing;Therapeutic;Tissues;Traumatic Brain Injury;tumor;Villous;Virus;Water;water channel;Western Blotting;Whole-Cell Recordings;Work

PROJECT_TITLE: How does mechanosensation contribute to choroid plexus function in health and disease?

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: PROJECT NARRATIVE. The experience of both elderly Mexican immigrants in the United States and that of older Mexico-based adults -connected to the US via their own past migration or that of their children - is greatly influenced by the accumulation of social and economic experiences over the life course, including contextual factors that shape immigrant inclusion. Using nationally representative panel data for 2006-2018 in the United States and 2001- 2018 in Mexico, we examine 1) how contemporary changes in factors affecting immigrant social inclusion are associated with the mental and physical health of Mexican immigrants and Mexico-based elderly with children in the United States; and 2) the way in which disadvantages experienced by these individuals across the life course are associated with chronic physical and cognitive health and mortality.

PI_NAMEs: RIOSMENA, FERNANDO  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Adult Children;Affect;Age;Aging;Attention;Attitude;cardiovascular health;Cardiovascular system;caregiving;Caring;Child;Chronic;Climate;Cognitive;comparative;contextual factors;Data;Data Set;depressive symptoms;Deterioration;Dimensions;disability;Disadvantaged;Disparity population;Economics;Elderly;Elements;Emotional;Employment;Environment;ethnic disparity;Exhibits;experience;Family;family support;Health;Health and Retirement Study;health care availability;healthy aging;Heterogeneity;human old age (65+);Immigrant;Immigration;Impaired cognition;Income;Individual;Injury;intergenerational;International Migrations;Joints;Latino Population;Latinx population;Legal;Legal Status;Life Cycle Stages;life span;Link;Location;Long-Term Effects;Measurement;Mental Health;Mexican;Mexican Americans;Mexico;migration;Migration Policy;mortality;mortality risk;Nonmigrant;novel;older adult;Outcome;Outcome Assessment;Parents;Pattern;Personal Satisfaction;physical conditioning;Policies;Politics;Population;population health;pressure;Process;Proxy;Psyche structure;Public Opinion;racial disparity;Remittance;Research;Return Migrations;Role;senescence;Shapes;Side;social;social inclusion;Social support;Social Work;spatiotemporal;Spouses;Stress;support network;Surveys;Testing;Time;United States;Variant;young adult

PROJECT_TITLE: Health of Aging Mexicans on Both Sides of the Border

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Firearms Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Suicide;Suicide Prevention;Violence Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Nearly half of all teen suicide deaths are caused by firearms. Lethal means safety involves limiting firearm access for teens at elevated suicide risk. It is an essential component of suicide prevention, yet is not done consistently or comprehensively in the Emergency Department (ED). This study will employ human-centered design to obtain teen and caregiver perspectives of lethal means safety planning, adapt an existing tool, and pilot the tool to improve patient-centered care of teens with elevated suicide risk presenting to the ED.

PI_NAMEs: HAASZ, MAYA  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adolescent;Adult;career;career development;Caregiver support;Caregivers;Cause of Death;Child;Childhood;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;Counseling;Country;Data;Decision Making;design;Development;Development Plans;digital;Educational workshop;Effectiveness;effectiveness/implementation trial;efficacy evaluation;efficacy trial;Emergency Department patient;Emergency Medicine;Ensure;evidence base;experience;firearm access;Firearms;follow-up;Funding;Future;Goals;Gun injury;hands on research;Health;high risk behavior;Household;Human;human centered design;implementation trial;improved;Individual;Injury;injury prevention;innovation;Intervention;Intervention Studies;Intervention Trial;Interview;lens;Mental Health;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;National Institute of Child Health and Human Development;Outcome;Parents;Participant;patient screening;Patient-Centered Care;pediatric emergency;Pediatrics;Perception;Personal Satisfaction;Physicians;pilot trial;Positioning Attribute;Prevention Measures;Prevention strategy;preventive intervention;primary outcome;programs;prototype;Provider;Qualitative Methods;Qualitative Research;recruit;Research;research and development;Research Personnel;Review Literature;Risk;Role;Safety;safety net;safety outcomes;secondary outcome;Self-Injurious Behavior;skills;Structure;success;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Tablets;Teenagers;Testing;therapy design;therapy development;tool;Training;Trauma;United States;user centered design;user-friendly;Voice;Youth

PROJECT_TITLE: TEEN LENS ED: TEen ENgaged LEthal meaNS planning for the Emergency Department

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Atrial fibrillation (AF) is the most common serious arrhythmia in human populations, but current treatment strategies only function to reduce symptoms, instead of treating underlying causes. The studies outlined by this proposal will expand our understanding of the genes required by atrial muscle cells to maintain heart rhythm, and how the expression of these genes is maintained at the appropriate level. We will examine a set of genes implicated in human AF and in two mouse models for their requirement to maintain heart rhythm and for their effectiveness as gene therapies to prevent AF and reverse established disease.

PI_NAMEs: SWEAT, MASON ERIC (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;adenylate kinase;Affect;Age;Alleles;Arrhythmia;ATAC-seq;Atrial Fibrillation;Atrial Function;blood pump;Cardiac Myocytes;CHD4 gene;Chromatin;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Connexin 43;connexin 45;Data;design;Development;Disease;driver mutation;effective therapy;Effectiveness;Enhancers;Etiology;FGF12 gene;gap junction channel;Gene Activation;Gene Expression;Gene Expression Regulation;gene therapy;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;genome wide association study;genomic locus;Genomics;Goals;Health Care Costs;healthcare burden;Heart;Heart Atrium;Heart Diseases;heart function;heart rhythm;Histone Deacetylase;Homeostasis;Human;improved;in vivo;Incidence;Ion Channel;Knowledge;Lead;lifetime risk;Link;Mediating;Mentors;Modeling;Molecular;mouse model;multiple omics;Mus;Muscle Cells;Mutagenesis;novel;Nucleosomes;Older Population;overexpression;Patients;Phenotype;Population;prevent;Prevention;Process;Proteins;recruit;reduce symptoms;Resolution;Role;single nucleus RNA-sequencing;Sinus;STK11 gene;Stroke;Structural Genes;Testing;Therapeutic;therapy development;Transcription Coactivator;transcription factor;Transcription Repressor;Treatment Efficacy;treatment strategy;Work

PROJECT_TITLE: The molecular determinants of atrial fibrillation

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: The overall goal of this project is to enable Veterans with partial paralysis due to incomplete spinal cord injury (iSCI) to improve their daily walking capabilities and become functional ambulators in the home or community environments. Approximately 15% of all Americans with SCI are Veterans, and the number of new cases with iSCI has been outpacing all others. We will achieve the goal of enhancing the functional walking ability and overall activity level of Veterans with iSCI by developing practical methods to control the activation of paralyzed or partially paralyzed muscles and seamlessly coordinate them with voluntary contractions to propel and stabilize the body based on feedback from wearable sensors that can estimate movement of the user's center of mass. This study progresses from initial computer simulations, through preliminary laboratory experiments, to clinical implementation with 10 volunteers with iSCI needing various degrees of stimulated assistance to walk naturally, intuitively vary walking speed, and recover from potentially destabilizing disturbances.

PI_NAMEs: TRIOLO, RONALD J (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Algorithms;American;Anterior;Assisted Living Facilities;Award;base;Categories;Characteristics;Clinical;clinical implementation;clinical translation;Clinical Trials;Communities;Compensation;Complement;Computer Simulation;cooperative study;Crutches;daily functioning;disabled;Elements;Ensure;Environment;Equilibrium;Event;falls;fear of falling;Feedback;follow-up;functional improvement;Gait;gait rehabilitation;Gait speed;Goals;Home;Household;Human;Impairment;Implant;improved;Individual;individual responsibility;Interruption;Intervention;Intuition;kinematics;knowledge of results;laboratory experiment;Lateral;Life;Limb structure;machine learning algorithm;machine learning method;Marketing;Measurable;Measurement;Measures;Methods;migration;Motion;motor control;Movement;Muscle;neural prosthesis;neural stimulation;neuromuscular stimulation;neuroprosthesis;operation;Paralysed;Paresis;Participant;Pattern;Performance;Peripheral Nerve Stimulation;Persons;Phase;Physiological;Posture;prevent;Process;programs;Recovery;rehabilitation research;research study;Research Subjects;Residual state;response;Sensitivity and Specificity;sensor;Series;Side;Societies;Speed;Spinal cord injury;Surface;System;Time;Veterans;volunteer;walker;Walking;walking performance;walking speed;walking stability;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Neural Stimulation to Enhance Community Mobility after Incomplete SCI

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans’ functional independence and quality of life.

PI_NAMEs: LEE, CATHY  (contact);WANAGAT, JONATHAN ;WILKINS, STACY S

PROJECT_TERMS: active lifestyle;Age;apolipoprotein E-4;Biological;Biological Markers;Biopsy;Blood;brain health;Brain-Derived Neurotrophic Factor;Clinical;Cognition;Cognitive;cognitive ability;cognitive benefits;cognitive function;Communities;comorbidity;comparison control;Data;Dementia;Educational Intervention;Elderly;Elements;Enrollment;Ethnic Origin;executive function;Exercise;exercise intervention;exercise prescription;exercise program;fitness;follow-up;Frequencies;functional independence;General Population;Goals;Health;Health education;Health Promotion;Health Status;Healthcare;high risk;human old age (65+);Impaired cognition;improved;indexing;Intervention;Knowledge;Link;Major Depressive Disorder;Measurement;Measures;Memory;Mental Depression;Military Personnel;military veteran;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;molecular marker;Muscle;Neurocognition;older adult;Outcome;Participant;Patient Selection;peripheral blood;Personal Satisfaction;Persons;Physical activity;Physical Fitness;Physical Function;Physical Performance;Population;Post-Traumatic Stress Disorders;predictive marker;Prevalence;primary outcome;programs;Provider;quadriceps muscle;Quality of life;Randomized;recruit;Risk;Role;Rural Health;Screening procedure;secondary outcome;Secondary to;sedentary;Serum;Site;Skeletal Muscle;Telephone;Testing;Traumatic Brain Injury;Uncontrolled Study;United States;Veterans;Veterans Health Administration;whole health;Work

PROJECT_TITLE: Relationship of exercise frequency, intensity, and fitness to improved cognition and biomarkers in Gerofit participants

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Drug resistance evolution is always a major threat to disease control and malaria drug resistance arises to each new frontline antimalarial drug. This Program Project renewal grant (P01) will use targeted genetic crosses to dissect the genetic complexity of artemisinin resistance in the malaria parasite Plasmodium falciparum emerging in Africa. This novel approach can extend well beyond artemisinin resistance and the malaria community by providing unprecedented insights into how genes control key drug resistance traits, with the goal of understanding evolutionary paths to resistance and ways to block the spread of drug resistance.

PI_NAMEs: FERDIG, MICHAEL T (contact);VAUGHAN, ASHLEY M

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Africa;African;Anti-malarials;Artemisinins;Back;benflumetol;Biocompatible Materials;Blood;Cells;Cessation of life;Chloroquine resistance;Chromosome Mapping;Clinical;clinical efficacy;Code;Combined Modality Therapy;Communities;Compensation;Coupled;Culicidae;Data;design;Development;disorder control;Drug Controls;drug development;Drug resistance;Drug Tolerance;Drug usage;Ensure;Equilibrium;Erythrocytes;Ethiopia;Evolution;Exhibits;Experimental Genetics;Falciparum Malaria;fitness;Funding;gene interaction;Genes;Genetic;genetic architecture;Genetic Crosses;Genetic Determinism;genetic linkage;Genetic Markers;Genetic Models;Genetic Transcription;Genome;genomic locus;Goals;Grant;Growth;Human;improved;Infection;insight;Intervention;Laboratories;Life Cycle Stages;Liver;Location;Malaria;Maps;Methodology;Minor;Modeling;Morbidity - disease rate;mortality;Mus;Mutation;novel strategies;novel therapeutics;Pan Genus;Parasite resistance;Parasites;Parents;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Plasmodium;Plasmodium falciparum;Population;pressure;Process;programs;Protocols documentation;Quantitative Trait Loci;Research Personnel;Research Project Grants;Resistance;Resolution;Resources;response;Role;Rwanda;scale up;Scheme;Sexual Transmission;single-cell RNA sequencing;Specificity;Sporozoites;Technology;Testing;Time;tool;trait;transmission process;Uganda;Validation;vector mosquito

PROJECT_TITLE: Harnessing the Power of Experimental Genetic Crosses to Probe Drug Resistance in Malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MN-M (J3)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE The Admin Core is responsible for management and communications of the P01 and will continue to utilize effective tools and practices to ensure personnel from the Admin Core, Core A, Core B, RP01, RP02, and RP03 work seamlessly together across sites. The Admin Core will partner with VEuPathDB to host an interactive data resource and develop tools to maximize data accessibility. The Admin Core will develop and maintain a repository of genetic cross progeny to share with the malaria research community.

PI_NAMEs: FERDIG, MICHAEL T (contact)

PROJECT_TERMS: Africa;African;Area;Back;Cells;Chromosome Mapping;Clinical;Collaborations;Communication;Communities;community building;Country;Cryopreservation;Data;data dissemination;data resource;data sharing;data sharing networks;data tools;Decision Making;Deposition;design;Drug resistance;Ensure;Equipment and supply inventories;Experimental Genetics;experimental study;Faculty;Feedback;Funding;Galaxy;Gene Frequency;Genetic;Genetic Crosses;Genetic Transcription;genetic variant;Genotype;Goals;Grant;high-throughput drug screening;Home;Human Resources;improved;Individual;Invaded;Knowledge;Leadership;Malaria;member;Modification;Monitor;operation;Parents;performance site;Phenotype;phenotypic data;Plasmodium falciparum;Population;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;Program Research Project Grants;programs;Recombinants;Recommendation;Records;repository;Research;Research Personnel;Resource Sharing;Resources;response;Science;Scientist;screening;segregation;sharing platform;Site;Structure;System;Systems Biology;tool;training opportunity;United States National Institutes of Health;Universities;Variant;variant of interest;virtual;Work


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Plasmodium falciparum experimental genetic crosses in chimpanzees were used to pinpoint genes involved in drug resistance to antimalarials. We have developed a human-liver chimeric mouse model (the FRG NOD huHep mouse) to replace the chimpanzee for the recovery of recombinant progeny from crosses. The ease of use of this model will allow us to understand P. falciparum Mendelian inheritance, which, in turn, will help explain the evolution and spread of parasite drug resistance.

PI_NAMEs: VAUGHAN, ASHLEY M (contact)

PROJECT_TERMS: Acetoacetates;Africa;Anopheles Genus;Anti-malarial drug resistance;Artemisinins;asexual;Blood;Cell Death;Cessation of life;Chimerism;Chromosome Mapping;Cloning;Collaborations;Culicidae;Data Set;Dedications;Development;dietary supplements;Drug resistance;Drug usage;Ensure;Erythrocytes;Ethics;Evolution;Excision;experience;Experimental Genetics;Feeds;fitness;Generations;Genes;Genetic Crosses;Genetic Determinism;genomic locus;Genomics;Genotype;Grant;Health;Hepatocyte;House mice;Human;Hydrolase;Immunocompromised Host;improved;In Vitro;Inbred NOD Mice;Infection;Infusion procedures;interest;Laboratories;Life Cycle Stages;Link;Liver;Malaria;Maps;Modeling;mouse model;Mus;novel;Pan Genus;Parasites;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;Population;Predisposition;pressure;Quantitative Trait Loci;Recombinants;Recovery;Recreation;Research;Research Project Grants;resistant strain;Salivary Glands;Sampling;skills;Splenectomy;Sporozoites;Technology;Testing;Time;Transgenic Organisms;United States National Institutes of Health;Work

PROJECT_TITLE: Experimental genetic crosses for malaria research


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE Core B will conduct molecular and bioinformatic analyses of cross progeny to determine the location of QTLs. As each QTL may contain multiple genes, we will use a suite of methods to fine map QTLs, followed by CRISPR/Cas9 gene editing to determine the causative genes and SNPs within each QTL region. This Core will work closely with RP01, RP02 and RP03.

PI_NAMEs: ANDERSON, TIM J (contact)

PROJECT_TERMS: Alleles;Bioinformatics;bioinformatics tool;Candidate Disease Gene;candidate identification;candidate validation;causal variant;Chromosome Mapping;Collaborations;combinatorial;Communities;conditional knockout;CRISPR/Cas technology;Data;Data Set;data tools;Databases;deep sequencing;Drug resistance;Exclusion;Experimental Genetics;experimental study;Funding;gene interaction;Gene Mutation;gene network;Genes;Genetic Crosses;genetic manipulation;Genome;genomic data;Genomics;Genotype;Goals;Haplotypes;Individual;Insertional Mutagenesis;interest;Knock-out;Libraries;Life;Link;Location;Malaria;Maps;Methods;Molecular;Mutagenesis;Mutation;nanopore;Parasites;Parents;Phase;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Play;Population;programs;Proteins;Quantitative Trait Loci;rapid technique;Recombinants;resistance gene;Resources;Rodent;Role;Signal Transduction;telomere;trait;Validation;Variant;whole genome;Work

PROJECT_TITLE: Peaks to genes: Fine mapping of QTLs and functional analysis


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Plasmodium falciparum experimental genetic crosses and downstream analysis of recombinant progeny can help determine genotypes associated with phenotypes. We will carry out genetic crosses to determine genotypes associated with phenotypes of mosquito and pre-erythrocytic life cycle stage development. Specifically, we will study the propensity for outcrossing in genetic crosses, the infectivity rate of sporozoites for the liver and the growth and development of the liver stage parasite.

PI_NAMEs: KAPPE, STEFAN HI (contact)

PROJECT_TERMS: Acceleration;Africa;Artemisinins;asexual;Back;Biology;Blood;Chromosome Mapping;Clinical;clinically relevant;Control Locus;Culicidae;Development;Disease;Drug resistance;drug-sensitive;enhancing factor;Erythrocytes;Ethiopia;Evolution;Experimental Genetics;fitness;Generations;Genes;Genetic;genetic approach;Genetic Crosses;Genetic Determinism;Genetic Recombination;Genetic Transcription;genomic locus;Genotype;Grant;Growth;Growth and Development function;Haploidy;Head Start Program;Hepatocyte;Human;in vitro Model;in vivo;Infection;interest;Invaded;Investigation;Life Cycle Stages;Liver;liver development;Malaria;Maps;Meiosis;Midgut;Modeling;Molecular;mouse model;Mutation;Oocysts;Parasite Control;Parasite resistance;Parasites;Parents;Partner in relationship;Pathway interactions;Phenotype;Plasmodium falciparum;Play;Population;Population Replacements;Process;Production;Recombinants;Reporting;Research;Research Project Grants;Resistance;Role;Salivary Glands;southeast Asian;Southeastern Asia;Speed;Sporozoites;success;System;Time;trait;transcription regulatory network;transmission process;Uganda;vector mosquito;Work

PROJECT_TITLE: Genetic determinants of pre-erythrocytic parasite fitness


PHR: PROJECT NARRATIVE Genetic linkage studies can be powerfully applied to discovering genes that control important phenotypes of malaria parasites such as drug resistance. We will apply our new technology to routinely generate genetic crosses of malaria parasites using ‘humanized’ mice that express human liver cells to generate 10 new genetic crosses strategically designed to map genes involved in resistance to the drug, artemisinin. This form of drug resistance is emerging in Africa and beginning to spread, with likely devastating consequences if unchecked.

PROJECT_TERMS: Affect;Africa;African;Anti-malarial drug resistance;Artemisinins;Automobile Driving;Biological Assay;Chloroquine resistance;Chromosome Mapping;clinical phenotype;Combined Modality Therapy;Complex;Country;CRISPR/Cas technology;design;Dose;driving force;Drug resistance;Drug usage;Encapsulated;Ensure;Evolution;Experimental Genetics;fitness;Frequencies;Funding;gene discovery;Gene Mutation;Gene Transfer Techniques;Generations;Genes;Genetic;genetic architecture;Genetic Crosses;Genetic Determinism;genetic linkage;genomic locus;Genotype;Geographic Locations;Growth;Half-Life;Head;Hepatocyte;Human;humanized mouse;improved;In Vitro;Individual;Knowledge;Life Cycle Stages;Link;Locales;Location;Malaria;Maps;Methods;Monitor;mouse model;Mus;mutant;Mutation;new technology;novel;Outcome;Parasite resistance;Parasites;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;Population;Population Analysis;Positioning Attribute;Predisposition;pressure;process optimization;Quantitative Trait Loci;Recombinants;Recovery;Regimen;Reporting;Research;Research Personnel;Resistance;resistance gene;response;Role;Scheme;Series;Signal Transduction;Southeastern Asia;success;Testing;Time;tool;trait;Validation;whole genome

PROJECT_TITLE: Real-time drug resistance emergence and spread in Africa


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Precision Medicine;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE RP03 aims to understand the genetic basis of drug resistance, post-exposure recovery and compensatory mechanisms. We will use key tools developed under the prior grant period, including SCeQTL mapping, Bulk Segregant Analysis, and pseudo-Bulk Segregant Analysis. This work depends upon resources in Cores A and B, and will be enhanced by the resources and findings in RP01 and RP02.

PI_NAMEs: CHEESEMAN, IAN HARRY (contact)

PROJECT_TERMS: Aftercare;Anti-malarials;Artemisinins;asexual;benflumetol;Biological Assay;Blood;Caloric Restriction;Candidate Disease Gene;candidate validation;Cells;Chloroquine;CRISPR/Cas technology;Cues;Development;drug development;Drug Exposure;Drug resistance;Drug Tolerance;Effectiveness;Environment;Excision;Experimental Genetics;Fever;fitness;Funding;Gene Expression;Generations;Genes;Genetic;Genetic Crosses;Genetic Determinism;Genetic Engineering;Genetic Polymorphism;Genetic Transcription;Genotype;Grant;Growth;Life Cycle Stages;Link;Longevity;Malaria;Maps;Mefloquine;Molecular;Mutation;next generation;novel;parasite genome;Parasites;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Plasmodium falciparum;Prediction of Response to Therapy;pressure;programs;Quantitative Trait Loci;Quinine;Recombinants;Recovery;Resistance;resistance mutation;Resources;response;Shapes;single-cell RNA sequencing;Temperature;Time;tool;transcriptome;transmission process;Treatment Failure;treatment strategy;Variant;Work

PROJECT_TITLE: Single cell approaches to unravel transcriptional responses to drug pressure


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Immunotherapy;Microbiome;Nutrition;Pediatric;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Novel therapies for food allergies and thorough understanding of the mechanisms associated with food allergy and tolerance are pressing needs of utmost priority. We will evaluate the safety and efficacy of microbiota transplantation therapy in teens with peanut allergy and investigate the role of novel biomarkers in predicting the outcome of peanut oral food challenge or peanut oral immunotherapy. We also will contribute extensively to the Consortium of Food Allergy Research as a Clinical Research Center through successful implementation, scientific expertise, and training of the next generation of NIH funded investigators skilled in food allergy.

PI_NAMEs: RACHID, RIMA  (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;age group;Allergic;Allergic Disease;Allergic Reaction;allergic response;Allergy to peanuts;Anaphylaxis;Antigen Receptors;Biological Products;biomarker driven;biomarker identification;Boston;Child;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;cytokine;Data;data management;Demographic Factors;desensitization;Development;Disease;Dose;Double-Blind Method;Encapsulated;Epithelial Cells;Epithelium;Ethnic Origin;Evaluation;experience;fecal transplantation;Food;food allergen;food challenge;Food Hypersensitivity;fundamental research;Funding;Future;gastrointestinal epithelium;Generations;Goals;gut microbiota;high risk;Human Resources;Immune;Immune Tolerance;Immunologic Markers;Immunologics;Immunotherapy;improved;Infrastructure;Intervention;Laboratories;Laboratory Markers;Leadership;Licensing;Life;Mediating;Mediator;meetings;member;metabolomics;microbiome;microbiome therapeutics;microbiota;microbiota transplantation;Mission;Mucous Membrane;Multi-Institutional Clinical Trial;National Institute of Allergy and Infectious Disease;next generation;novel;novel marker;novel therapeutic intervention;novel therapeutics;Observational Study;operation;Oral;oral immunotherapy;oral tolerance;Outcome;outcome prediction;Participant;Pathogenesis;Pathway interactions;Patient Recruitments;Patients;Pediatric Hospitals;phase I trial;phase II trial;Physicians;Placebo Control;Play;Precision therapeutics;primary outcome;Proteins;Quality Control;Race;Reaction;receptor;receptor expression;Records;recruit;Regulatory T-Lymphocyte;repository;Research;Research Personnel;resistin;Risk Factors;Role;Safety;Scientist;Seasons;secondary outcome;Serum;Services;Site;skills;Solid;success;Surface;Teenagers;Testing;Th2 Cells;Therapeutic Clinical Trial;Training;translational study;transplantation therapy;Treatment Efficacy;TSLP gene;United States National Institutes of Health

PROJECT_TITLE: Consortium for food allergy research clinical center CoFar


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Triple Negative Breast Cancer (TNBC) is one of the most lethal forms of this disease, in part, due to the lack of effective therapies. This proposal will investigate whether blocking a factor that is highly active in TNBC known as NEK2 can increase the effectiveness of drugs that typically have limited impact on this disease. This may provide a new collection of drugs to improve the outcomes of patients with TNBC.

PI_NAMEs: KERI, RUTH A. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acceleration;Antineoplastic Agents;Biological Assay;Biological Models;BRCA1 gene;BRCA1 Mutation;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Epithelial Cells;cancer subtypes;CDK4 gene;Cell Aging;Cell Cycle;Cell Death;Cell Line;Cell model;Cells;Centrosome;Chromosomal Instability;Chromosomes;Chronic;Clinical;Clinical Trials;Collection;Cyclin-Dependent Kinase Inhibitor 2A;cytotoxic;Cytotoxic Chemotherapy;Data;Development;Disease;disease heterogeneity;Disease Outcome;disorder subtype;DNA Repair;Dose Limiting;Drug Combinations;drug efficacy;drug repurposing;Drug Targeting;Drug usage;effective therapy;Effectiveness;Enzymes;epithelial to mesenchymal transition;Equipment and supply inventories;ERBB2 gene;Estrogen receptor positive;Estrogen Receptors;Event;Evolution;FDA approved;Foundations;Functional disorder;Genes;genetic signature;Genomics;Germ-Line Mutation;Growth;homologous recombination;Immunotherapy;improved;improved outcome;In Vitro;in vivo Model;inhibitor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mitosis;Mitotic;mouse model;Mus;Mutation;Normal Cell;novel;novel strategies;novel therapeutics;overexpression;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Poly(ADP-ribose) Polymerase Inhibitor;Population;Progesterone Receptors;Radiation therapy;receptor;replication stress;Resistance;Resistance development;response;Safety;standard of care;stemness;synergism;targeted agent;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;Toxic effect;transcriptome;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Promotion;Tumor Suppression;Xenograft Model

PROJECT_TITLE: Targeting NEK2 to potentiate standard of care therapies for breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Endocrine Disruptors;Estrogen;Genetics;Prevention;Women's Health Research

ORG_CITY: NEWTON

ORG_NAME: SILENT SPRING INSTITUTE

PHR: PROJECT NARRATIVE Most human breast carcinogens are genotoxic and/or endocrine-active, and the combination of genotoxicity with endocrine activity is predicted to increase breast cancer risk more than either effect alone. Understanding these effects is vital, because exposure to chemicals with these activities is common from diet, pharmaceuticals, consumer products, and the environment. To investigate the joint risk of genotoxic and endocrine-active exposures, this project will use novel multiplexed spatial biology to measure how chemicals interact early in tumor development, expanding knowledge of fundamental mechanisms of breast carcinogenesis and providing a framework for rapid prediction and identification of human health hazards.

PI_NAMEs: KAY, JENNIFER ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Age;age related;Anabolism;Animals;Apoptosis;Award;bioimaging;Biological;Biological Markers;Biology;biomarker identification;biomarker performance;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Carcinogenesis;Breast Epithelial Cells;breast tumorigenesis;cancer diagnosis;Cancer Etiology;cancer initiation;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;Cell Proliferation;cell type;Cells;Chemical Exposure;Chemicals;Classification;Complex;consumer product;cytotoxicity;Dedications;Development;Diet;dimethylbenzanthracene;DNA Damage;DNA Markers;early detection biomarkers;Endocrine;Endocrine disruption;Environment;Environmental Risk Factor;Epithelial Cells;Estradiol;Estrogen Receptors;estrogenic;Estrogens;Ethinyl Estradiol;experience;experimental study;Exposure to;Foundations;genotoxicity;Goals;Government;hazard;Health Hazards;Hepatocarcinogenesis;Histologic;Hormonal;hormonal signals;Hormone Responsive;Hour;Human;Hyperactivity;Immunofluorescence Immunologic;In Vitro;Individual;insight;International Agency for Research on Cancer;international scientific organization;Intestines;Ionizing radiation;Joints;K-Series Research Career Programs;Knowledge;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Mammary Tumorigenesis;Manuscripts;Massachusetts;Measures;Mentors;Methods;Microscopic;Modeling;Modernization;Molecular;molecular marker;Morphology;multimodality;Mutagenesis;National Institute of Environmental Health Sciences;Noise;novel;novel strategies;Observational Study;Outcome;Pathway interactions;Pharmacologic Substance;Population;Pregnancy;Prevention strategy;Process;Progesterone;Proliferating;Rattus;Research;Research Design;Resolution;response;Risk;Risk Assessment;risk prediction;Rodent;Rodent Model;Scientist;Serum;Shapes;Signal Transduction;single cell analysis;skills;specific biomarkers;Structure;Techniques;tenure track;Time;Tissues;tool;Toxicology;Training;Translating;tumor;Universities;Woman;Women's Health;Women's mortality;xenoestrogen

PROJECT_TITLE: Quantifying early biomarkers of mammary carcinogenesis with multiplexed spatial biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K0)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Health Services;Nutrition;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The proposed Consortium of Food Allergy Research Clinical Research Center: Cincinnati Children's Hospital Medical Center (CoFAR-CRC:CCHMC) aims to bring the experience, expertise, and scientific productivity and the diverse patient populations of CCHMC to CoFAR. The CoFAR-CRC:CCHMC approach to research is multipronged and self-sustaining by attracting patients with excellent care and creating and maintaining databases and registries supported by biospecimen collection and biobanking. Those are utilized in conducting mechanistic research that forms the basis of discoveries and clinical trials and advances knowledge that improves patient care and attracts more patients.

PI_NAMEs: ASSA'AD, AMAL HALIM (contact);ROTHENBERG, MARC E.

PROJECT_TERMS: 8 year old;Address;Adherence;Adult;Air;Allergen Immunotherapy;Allergens;Allergic Disease;arm;Aryl Hydrocarbon Receptor;aryl hydrocarbons;B-Cell Antigen Receptor;Bacteria;Basic Science;Basophils;biobank;Biopsy;Blood;Caring;Cell Differentiation process;Child;Classification;Clinic;clinical care;clinical center;Clinical Research;Clinical Trials;Collection;Communities;Data;Databases;Development;dietary;Disease;Doctor of Philosophy;Dose;Education;Enterocolitis;Environment;Environmental Exposure;Environmental Risk Factor;Eosinophilic Esophagitis;Epithelium;Esophagus;experience;Extramural Activities;Faculty;Family;Food;food allergen;Food Hypersensitivity;Funding;Genes;Genetic Transcription;Guidelines;Holidays;Hypersensitivity;IgE;Immunology;improved;Individual;Infant;Journals;Knowledge;Leadership;Ligands;Longitudinal cohort study;Maintenance;Mediating;Medical center;Mentors;Metabolic;microbiome;Minority;Molecular;Molecular Profiling;Multi-Institutional Clinical Trial;multidisciplinary;novel marker;Oral;oral immunotherapy;Pathogenesis;Pathology;Pathway interactions;Patient Care;patient population;Patient Schedules;Patients;Pattern;Pediatric Hospitals;pharmacologic;Pharmacologic Substance;Phase;Population;preservation;Prevalence;primary outcome;Procedures;Productivity;programs;prospective;Protease Inhibitor;protective effect;Proteins;Protocols documentation;Publishing;Readiness;recruit;Registries;Research;Research Project Grants;Role;Sampling;sensor;Services;Signal Transduction;single-cell RNA sequencing;Solid;Stratum corneum;Structure;Teacher Professional Development;Therapeutic;toxicant;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Consortium of Food Allergy Research Clinical Research Center at Cincinnati Children's Hospital Medical Center (CoFAR-CRC:CCHMC)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Contingency management is one of the most effective behavioral health tools available for substance use disorder treatment, yet it is one of the least available to patients due to implementation barriers. This proposed research seeks to adapt a contingency management program to fit a new context within a low-threshold buprenorphine program providing services to patients with opioid use disorder via mobile van. Given the worsening opioid overdose crisis in the United States, this project has the potential for a significant public health impact by contributing to knowledge on how to adapt and implement contingency management to make it more accessible to patients with opioid use disorder, particularly those at highest risk of overdose death.

PI_NAMEs: MESSMER, SARAH  (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: addiction;Address;Adoption;Area;Award;behavioral health;Board Certification;Buprenorphine;Capital;care costs;Caring;Cessation of life;Chicago;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Communities;contingency management;cost;Cost Analysis;Country;Data;Development;digital;Drug Screening;Drug user;Effectiveness;Enrollment;Ethics;Event;evidence base;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Face;flexibility;Focus Groups;Foundations;Funding;Goals;Harm Reduction;harm reduction programs;Health Insurance;Health Personnel;Health Services Accessibility;Healthcare Systems;high risk;Hot Spot;implementation barriers;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;Incentives;Injectable;Insurance Coverage;Internal Medicine;Intervention;Interview;Knowledge;Lead;Life;Link;medication for opioid use disorder;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methadone;Modeling;mortality;Naltrexone;Nature;opioid mortality;opioid overdose;opioid treatment program;opioid use;opioid use disorder;Outcome;Outcome Study;Overdose;overdose death;Patient Care;patient retention;Patients;Pediatrics;Persons;Pharmaceutical Preparations;Pilot Projects;Policy Maker;Primary Care;Primary Care Physician;Process;programs;Provider;Public Health;Randomized, Controlled Trials;Recovery;Reporting;Research;Research Personnel;Resources;response;secondary outcome;Services;Side;Site;social stigma;standard care;substance use;Substance Use Disorder;substance use treatment;Time;tool;Training;Transportation;treatment duration;United States;uptake;Urine;Work

PROJECT_TITLE: Implementation of Contingency Management in a Mobile Low-Threshold Buprenorphine Clinic

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


FUNDING_MECHANISM: OTHERS

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Assisted transfers are known to be one of the most strenuous activities of daily living leading to back and shoulder pain and injury to the caregiver and potential harm to the Veteran if not performed correctly. The Caregiver Assisted Transfer Technique Instrument (CATT) is a tool that was designed to identify deficits in technique that if corrected could reduce the risk of injuries to both the caregiver and their care recipients. Current work involves establishing the reliability and validity of the CATT so that it can be widely disseminated for clinical use in the future. Home-based fitness products involving access to live or on demand content and virtual reality cycling have become widely popular and beneficial for increasing fitness and motivation among able-bodied individuals however they are not accessible or tailored to the needs of wheelchair users. We aim to develop ParaCycle, a upper arm exercise bike that will be compatible with commercial fitness apps that offer virtual reality, social and motivational features to help support increased physical activity among Veterans.

PI_NAMEs: KOONTZ, ALICIA M. (contact)

PROJECT_TERMS: Activities of Daily Living;Architecture;Area;Assessment tool;Award;Back Pain;Biomechanics;care recipients;career;Caregivers;Client;Clinic;Clinical;clinical diagnostics;Communities;Community Participation;Computers;Conflict (Psychology);design;Devices;Diagnostic Equipment;Education;Engineering;Environment;ergonomics;Evaluation;Exercise;Fellowship;fitness;Functional disorder;Funding;Future;Goals;Grant;Grant Review;Growth;Guidelines;Health care facility;Home;Human Engineering;improved;Independent Living;Individual;informal caregiver;Injury;instrument;instrumentation;International;Intervention;Investigation;iterative design;Journals;Kinetics;Laboratory Research;Leadership;Lifting;Lived experience;Lower Extremity;Manual wheelchair;Measures;Mechanics;Medical;member;Mental Health;Mentors;military veteran;Motivation;Pain;pain relief;Paper;Participant;Peer Review;Performance;Persons;PF4 Gene;Physical activity;physical conditioning;Policies;pre-doctoral;Prevention;programs;Property;Psychometrics;Publications;Publishing;Quality of life;Rehabilitation therapy;Research;Research Activity;Research Personnel;Review Literature;Risk;Risk Reduction;Science;Scientist;Self-Help Devices;Seminal;Series;Services;Shoulder Pain;social;Social support;Spinal cord injury;Strenuous Exercise;success;Surface;System;Task Performances;technical report;Techniques;Technology;Testing;Time;tool;Training;Training Programs;Transportation;United States;Upper arm;Upper Extremity;usability;Validation;Validity and Reliability;Veterans;vibration;virtual reality;web site;Wheelchair propulsion;Wheelchair user;Wheelchairs;Work

PROJECT_TITLE: Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  Many mutations (about 6%) in cancer lead to serines. Despite the prevalence of serine-acquiring mutations in cancer, methods to target them are scarce. This project will develop a new chemical strategy to target serines in cancer through a covalent mechanism and discover inhibitors for EGFR(C797S) and BTK(C481S), two commonly occurring oncogenic mutants.

PI_NAMEs: ZHANG, ZIYANG  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Affinity Chromatography;Amino Acids;Biological Assay;Breathing;cellular transduction;Chemicals;Chemistry;chemoproteomics;Clinical;Complement;Cysteine;design;drug discovery;empowerment;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Family;Goals;Human;inhibitor;KRAS2 gene;Lactones;Lead;Libraries;Ligands;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methods;Missense Mutation;Modification;mutant;Mutation;Natural Products;Oncogenes;Oncogenic;Pharmaceutical Preparations;Phosphotransferases;Prevalence;Proteasome Inhibitor;Proteinase 3;Proteins;Proteome;Proteomics;Quinazolines;Research;Resistance;Resolution;salinosporamide A;scaffold;Serine;Signal Transduction;Site;stereochemistry;Structure;targeted cancer therapy;Testing;tool;Toxic effect;Work

PROJECT_TITLE: Expanding the targetable landscape in cancer with serine-targeting covalent ligands

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J2)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung;Machine Learning and Artificial Intelligence;Nutrition;Prevention;Tobacco;Tobacco Smoke and Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Despite growing evidence of nutrition’s role in modulating the risk of COPD and COPD-related manifestations, we lack a mechanistic understanding of how dietary chemicals may synergistically exert their influence. Here, we develop a new set of machine learning and network science-based methods specifically designed to explore the impact of small molecules directly derived from food digestion, absorption, and related metabolism (dietary xenobiotics) on COPD exacerbation frequency and severity. These methods will help identify tailored interventions, combining pharmacological and dietary approaches, to mitigate lung disease through the use of Precision Nutrition.

PI_NAMEs: MENICHETTI, GIULIA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: absorption;Acute;Address;Adherence;Agreement;Algorithms;Automobile Driving;Award;Biochemical Reaction;Biological Process;Biology;Biomedical Research;career;Cause of Death;Chemicals;Chronic Obstructive Pulmonary Disease;cigarette smoking;Classification;Clinical;clinical practice;clinical training;Cohort Studies;combustible cigarette;Complex;Data;deep learning model;design;Development;Developmental Process;Diet;dietary;dietary approach;Dietary Component;Dietary Intervention;Dietary Practices;Digestion;Dimensions;Disease;Disease susceptibility;endophenotype;Ensure;Environmental Exposure;epidemiology study;Epigenetic Process;experience;Food;Food Access;former smoker;Foundations;Frequencies;Goals;Human;Income;Individual;Inflammatory;Inherited;insight;Intake;Intervention;Knowledge;Learning;learning algorithm;learning strategy;Link;longitudinal analysis;Lung;Lung Diseases;Machine Learning;Mediterranean Diet;Mentors;Metabolism;metabolomics;Methodology;Methods;microbiome;Minority;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Neighborhoods;Nested Case-Control Study;Network-based;novel;nutrition;Omega-3 Fatty Acids;Outcome;Participant;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Plants;Plasma;precision nutrition;predictive signature;Predisposition;Process;prospective;Prospective cohort;protein protein interaction;Proteins;Proteomics;Pulmonology;randomized trial;Research;Research Design;Research Personnel;Respiratory Disease;Risk;Risk Factors;Role;Science;secondary metabolite;Severities;sex;skills;small molecule;Smoker;Smoking;Smoking History;stem;Techniques;Testing;theories;Training;trait;transcriptomics;Transport Reaction;Xenobiotics

PROJECT_TITLE: Methods for Unraveling the Impact of Dietary Xenobiotics on COPD Exacerbations with Multi-Dimensional Networks


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: While long-term opioid therapy for chronic pain is common, harms of continuing it may outweigh benefits for many patients and tapering may be recommended; however, recent evidence also highlights potential harms associated with tapering or discontinuing opioids. Limited data exists on strategies for patient-centered opioid tapering and managing chronic pain among patients prescribed long-term opioid therapy. To address these unanswered questions and help inform VHA’s decisions about pain care resource deployment, our overarching aim is to emulate a three-arm, randomized controlled trial where we will compare two active interventions to a matched usual care group on the primary outcome of pain-related interference and secondary outcomes of opioid dose reduction, uptake of nondrug pain treatment, and health-related quality of life. We will also examine outcomes for pre-specified high-risk subgroups and, among patients who tapered opioid doses, will compare rates of patient-reported harms (namely, worsening pain and quality of life).

PI_NAMEs: BECKER, WILLIAM C;EDMOND, SARA  (contact);HAMMETT, PATRICK JOHN

PROJECT_TERMS: addiction;Address;arm;Caring;Characteristics;chronic pain;chronic pain management;clinical practice;Cloning;cohort;Collaborations;collaborative care;comparative effectiveness;comparative effectiveness study;Control Groups;Country;Data;Data Adjustments;design;disability;Dose;Electronic Health Record;Enrollment;Ensure;evidence base;experience;Funding;Guidelines;Health;health related quality of life;Health Services;Health Services Research;high risk;implementation questions;improved;inclusion criteria;Internist;Intervention;Mental Depression;Methods;Modeling;non-drug;Opioid;opioid tapering;opioid therapy;opioid use;Outcome;Pain;Pain interference;Pain management;pain outcome;pain reduction;Participant;patient oriented;Patient-Focused Outcomes;Patients;Personal Satisfaction;Policies;Positioning Attribute;Post-Traumatic Stress Disorders;pragmatic randomized trial;pragmatic trial;prescription opioid;Primary Care;primary outcome;Productivity;Prospective cohort;Psychologist;Public Health;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;real world application;Recommendation;recruit;Reporting;research and development;Research Institute;Research Personnel;Resources;Safety;Sampling;secondary outcome;Site;skills;Source;Specific qualifier value;study population;Subgroup;Training;treatment as usual;trial enrollment;uptake;usual care arm;Veterans;Veterans Health Administration;Voice

PROJECT_TITLE: EVOLVE: Emulated trial of the VOice study for improving pain and reducing Long-term opioid use for VEterans

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative - Overall  Vaccines are a demonstrably effective tool for blunting the global health consequences of emerging infectious diseases like COVID; however, they must be delivered quickly to limit outbreak spread and reduce human mortality. Here, two different programmable vaccine platforms primed for quick deployment will be compared and characterized. The knowledge and technology gained from this project will enable a rapid and effective response to the next pandemic.

PI_NAMEs: FELGNER, PHILIP LOUIS (contact)

PROGRAM_OFFICER_NAME: BRIDWELL, ANNE ELIZABETH MAYER

PROJECT_TERMS: adaptive immunity;Address;Adherence;Adjuvant;Animal Model;Animals;Antibodies;Antigens;Authorization documentation;Basic Science;Biological Assay;Bunyavirales;Clinic;Clinical;clinical development;Clinical Trials;cohort;Collaborations;Collection;college;Communicable Diseases;comparative;Computer software;COVID-19;Data;Decision Making;Disease;Disease Outbreaks;Elements;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;emerging virus;Ensure;Enzyme-Linked Immunosorbent Assay;epidemic preparedness;experience;Family;Family Characteristics;Family Picornaviridae;Future;future outbreak;future pandemic;Genes;global health;Goals;Government;Head Start Program;Health;Healthcare;Human;human mortality;Humanities;imager;Immune response;immunogenicity;industry partner;Infection;innovation;International;Knowledge;Learning;lipid nanoparticle;Lipids;Machine Learning;man;manufacture;Manufacturer;Medicine;member;Microbe;microbial;microorganism;Mission;Modeling;Monitor;Monoclonal Antibodies;Movement;mRNA lipid nano particle vaccine;National Institute of Allergy and Infectious Disease;nonhuman primate;novel vaccines;Organoids;Orthobunyavirus;outbreak concern;outbreak prediction;Outcome;pandemic pathogen;pandemic potential;pandemic preparedness;Paramyxovirus;pathogen;Pathway interactions;Pennsylvania;Personal Satisfaction;Pharmacologic Substance;Phase;pre-clinical research;Primates;Process;Protein Microchips;Proteins;prototype;Readiness;Reagent;Recombinant Proteins;Recombinants;Research Personnel;Resource Sharing;response;RNA vaccine;Rodent;Safety;Science;Scientist;Screening procedure;Sentinel;Series;serosurveillance;Solid;System;Technology;Testing;timeline;tool;Total Quality Management;Translational Research;United States National Institutes of Health;Universities;vaccine access;Vaccine Adjuvant;vaccine development;vaccine discovery;vaccine distribution;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine response;Vaccines;Viral;Viral Proteins;Virginia;Virus;Wit

PROJECT_TITLE: The UCI Vaccines for Pandemic Preparedness Center (VPPC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (J1)]


PROJECT_TERMS: Academia;Acceleration;Adherence;Adjuvant;Basic Science;Biophysics;Biotechnology;Budgets;built environment;Characteristics;Clinical;Collaborations;Communication;Communities;data management;data sharing;Decision Making;Emergency Situation;emerging virus;Ensure;Equipment;experience;Family;Family Picornaviridae;Funding;Goals;Grant;Guidelines;Human;immunogenicity;Industry;Industry Collaboration;industry partner;Infection;Infrastructure;Laboratories;Leadership;Licensing;Manufacturer;medical schools;meetings;member;Messenger RNA;mRNA lipid nano particle vaccine;National Institute of Allergy and Infectious Disease;operation;Orthobunyavirus;outbreak concern;pandemic pathogen;pandemic preparedness;Paramyxovirus;Pathogenicity;Periodicals;Persons;Pharmacologic Substance;Physiology;Population;Primates;Process;Productivity;professor;programs;Protein Microchips;Proteins;Protocols documentation;prototype;Provider;Reagent;Recombinant Proteins;Records;Reporting;Research;Research Personnel;Research Project Grants;Resources;Safety;Schedule;screening;Sentinel;Series;Serology;serosurveillance;Supervision;symposium;System;Testing;tool;Training;Translational Research;Travel;United States National Institutes of Health;universal vaccine;Universities;Update;Vaccination;vaccine development;vaccine discovery;vaccine platform;Vaccine Research;vaccine response;Vaccines;virtual;Virus;web site;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: ZHENG, KAI  (contact)

PROJECT_TERMS: Acceleration;Adherence;Algorithms;Archives;Basic Science;Clinical Sciences;cloud based;Code;Communities;Computer software;computing resources;cost effectiveness;Custom;Data;data acquisition;Data Coordinating Center;data exchange;data integrity;data lake;data management;data quality;data sharing;data sharing networks;Data Storage and Retrieval;data submission;design;digital;Documentation;Emergency Medicine;Ensure;Environment;Evaluation;FAIR principles;Generations;health data;health science research;improved;Informatics;informatics infrastructure;Information Technology;Infrastructure;interoperability;Life Cycle Stages;Metadata;Monitor;National Institute of Allergy and Infectious Disease;Nature;pandemic preparedness;Play;Policies;Procedures;Process;professor;programs;Proxy;Quality Control;Readiness;Research;Research Personnel;Research Project Grants;response;Role;Science;Secure;Services;sharing platform;software systems;Specific qualifier value;Standardization;success;System;Technology;timeline;Total Quality Management;Translational Research;Translations;vaccine candidate;vaccine effectiveness;Vaccines;Vertebral column;Work

PROJECT_TITLE: Data Management Core


PI_NAMEs: BOTTAZZI, MARIA ELENA (contact)

PROJECT_TERMS: Acceleration;Animals;Archives;Arthropods;bench to bedside;Biological;Biological Products;Bunyavirales;Chagas Disease;Chiroptera;climate change;Clinic;Clinical Trials;cloud based;college;Computer software;coronavirus vaccine;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 vaccine;Data;data management;design;Development;digital;Disease;Dose;educational atmosphere;Electronic Medical Records and Genomics Network;Emerging infection;Ensure;Environment;Equipment;Equipment and supply inventories;Evaluation;Event;expectation;experience;Family;Family Picornaviridae;first-in-human;Fostering;Future;future pandemic;Generations;Goals;Government;Grant;Hookworm Infections;Human;improved;India;Indonesia;Industrialization;insight;Institution;Interview;Investigational Drugs;manufacture;Manufacturer;Medicine;member;Mission;Monitor;neglect;new pandemic;novel;novel coronavirus;novel vaccines;pandemic preparedness;Paramyxovirus;Pathway interactions;Pediatric Hospitals;Performance;Periodicals;Phase;phase II trial;pre-clinical;pre-clinical research;Procedures;Process;Productivity;Protocols documentation;prototype;Readiness;Recombinant Proteins;Research;research and development;research clinical testing;Research Project Grants;Resources;Risk Management;Rodent;Schistosomiasis;Science;self reliance;Series;Site Visit;Speed;Standardization;Surveys;System;technical report;Technology;Technology Transfer;Testing;Texas;Therapeutic;therapeutic candidate;Time Management;timeline;tool;Total Quality Management;Toxicology;Translations;Vaccine Antigen;vaccine candidate;vaccine development;vaccine discovery;Vaccines;Virus;Zoonoses

PROJECT_TITLE: Regulatory Science Core


PI_NAMEs: WAGAR, LISA  (contact)

PROJECT_TERMS: Acceleration;adaptive immune response;American;Animal Model;Animals;Antibodies;Antigens;Autopsy;Avidity;B-Lymphocytes;Benchmarking;Biological Assay;Blood;Bone Marrow;Cells;Cellular Immunity;Chemistry;Clinical Trials;cohort;Communicable Diseases;Complement;Controlled Study;cross reactivity;cytokine;Data;design;Development;Dose;draining lymph node;experimental study;Failure;Family;Family Picornaviridae;Flow Cytometry;future pandemic;Goals;Health;high throughput screening;Human;human model;Humoral Immunities;Immune;Immune response;Immunity;Immunize;immunogenic;immunogenicity;Immunologics;Immunology;In Vitro;in vitro Model;in vivo;Individual;Infection;Influenza;Innate Immune Response;insight;Kinetics;lymph node biopsy;lymph nodes;Lymphoid Tissue;Macaca;Macaca mulatta;Measurement;Measures;Modeling;mouse model;Mucous Membrane;multiple data sources;Mus;nonhuman primate;novel vaccines;Organoids;Orthobunyavirus;pandemic potential;pandemic preparedness;pandemic virus;Paramyxovirus;pathogen;peripheral blood;Phenotype;Plasma;Plasma Cells;Plasmablast;Population;predictive marker;Primates;Process;Production;Productivity;programs;response;Risk;Safety;Sampling;screening;Screening procedure;seroconversion;Serology;Serum;Structure of germinal center of lymph node;System;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Time;tool;transcriptomics;translational goal;translational immunology;translational potential;unvaccinated;Vaccinated;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;vaccine immunogenicity;vaccine response;vaccine safety;Vaccines;Virus

PROJECT_TITLE: Translational Immunology Core


PI_NAMEs: LIU, CHANG C (contact)

PROJECT_TERMS: 2019-nCoV;Antibodies;Antibody Response;antibody test;Antigens;Area;Bar Codes;Behavior;Binding;Bioinformatics;Capsid;Cells;Collection;COVID-19;Custom;design;Development;diagnostic tool;Disease Outbreaks;Effectiveness;Epitope Mapping;Epitopes;Evolution;Family;Family Picornaviridae;fitness;Future;future outbreak;future pandemic;Generations;Goals;HIV;Human;Immune;Immune response;Immunity;improved;In Vitro;Libraries;Location;Machine Learning;Measures;member;Membrane Fusion;Modeling;Monoclonal Antibodies;mutant;Mutate;mutation screening;nanobodies;new pandemic;novel;Orthobunyavirus;outbreak concern;pandemic disease;pandemic preparedness;Paramyxovirus;polyclonal antibody;Population;Preparation;prevent;prevent pandemics;Process;Property;prototype;Reagent;Research;Resources;Rupture;Services;Side;side effect;simulation;Speed;stem;success;Surface;Surface Antigens;synergism;Technology;therapeutic candidate;Therapeutic Monoclonal Antibodies;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine-induced antibodies;Vaccines;Variant;Viral;Viral Antigens;Virion;Virus;Work;Yeasts

PROJECT_TITLE: Antibody, Epitope and Machine Learning Core


PI_NAMEs: LIANG, LI  (contact)

PROJECT_TERMS: 2019-nCoV;Adjuvant;Agonist;Animal Model;Animals;Antibodies;Antibody Response;Antigens;Biochemical;biodefense;Biological;Biological Assay;Biophysics;Bunyavirales;Characteristics;Chlamydia;Collaborations;cost;Coxiella;Cyclic GMP;design;Documentation;Dose;Encapsulated;Ensure;Evaluation;Family;Family Picornaviridae;Fermentation;Flow Cytometry;Formulation;Funding;future pandemic;Goals;Human;Immune response;Immunity;Immunization;immunogenicity;Influenza;Intramuscular;Lead;lead candidate;lipid nanoparticle;Lipids;Manufacturer;manufacturing scale-up;Messenger RNA;microbial;Microfluidics;Modeling;Mucosal Immunity;Mus;nanoemulsion;nanoparticle;National Institute of Allergy and Infectious Disease;nonhuman primate;novel;Oils;Orthobunyavirus;pandemic potential;pandemic preparedness;Paramyxovirus;pathogen;Preparation;Process;process evaluation;Production;programs;Protein Microchips;Proteins;Recombinant Proteins;Recombinants;Reducing Agents;Reproducibility;response;RNA vaccine;Rodent;Route;Sampling;Science;Serum;Spleen;Squalene;System;T cell response;T-Lymphocyte;Technology;Technology Transfer;Testing;Time;Tissues;translational immunology;Vaccine Antigen;vaccine candidate;vaccine development;vaccine formulation;vaccine immunogenicity;Vaccine Research;Vaccines;Virus;Virus-like particle;Water;Work

PROJECT_TITLE: Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness


PI_NAMEs: PARDI, NORBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Amino Acid Sequence;Animal Model;Animals;Antibody Response;Antigen Targeting;Antigens;B-Lymphocytes;Bunyavirales;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cells;chikungunya;Clinical;Clinical Trials;Collaborations;Communicable Diseases;Complex;COVID-19 pandemic;Death Rate;design;Development;Disease Outbreaks;Ebola;Ebola virus;Encapsulated;Evaluation;experience;experimental study;Face;Family;Family Picornaviridae;Ferrets;flexibility;Formulation;Future;future outbreak;Goals;Helper-Inducer T-Lymphocyte;Human;Human Herpesvirus 2;Immune response;immunogenic;immunogenicity;Immunoglobulin G;In Vitro;Influenza;Influenza A Virus, H1N1 Subtype;influenzavirus;Infrastructure;Investments;Lead;Length;lipid nanoparticle;Lipids;Malignant Neoplasms;Mammalian Cell;member;Memory B-Lymphocyte;Messenger RNA;Middle East Respiratory Syndrome;Modeling;Mus;nonhuman primate;novel;Nucleosides;Orthobunyavirus;pandemic disease;pandemic pathogen;pandemic potential;pandemic preparedness;Paramyxovirus;pathogen;pathogenic virus;Pathogenicity;Phase;Plasma Cells;pre-clinical;Pre-Clinical Model;preclinical study;Preventive vaccine;Process;Production;programs;protective efficacy;protein purification;Proteins;prototype;Regimen;response;RNA vaccine;Rodent;SARS coronavirus;Structure of germinal center of lymph node;Synthetic Vaccines;System;T-Lymphocyte;Testing;translational immunology;translational potential;transmission process;vaccine candidate;vaccine development;vaccine platform;Vaccines;viral epidemic;Virus;Work;ZIKA;Zika Virus

PROJECT_TITLE: Project 2: mRNA vaccine development against Bunyaviruses, Paramyxoviruses and Picornaviruses


PI_NAMEs: RONCA, SHANNON  (contact)

PROJECT_TERMS: Acute;adaptive immunity;Adjuvant;Animal Model;Antibodies;Antigens;Behavioral;blood-brain barrier permeabilization;Brain;Cache Valley virus;Cell model;Cells;chemokine;chemokine receptor;Clinical Trials;Coculture Techniques;college;combat;Consult;CRISPR/Cas technology;cross immunity;cross reactivity;cytokine;Development;Disease;Disease Outcome;Dose;efficacy validation;Epitope Mapping;Family;Fatigue;Fever;Flow Cytometry;Future;Generations;Genes;Glycoproteins;Goals;Harvest;Histologic;Histopathology;Human;Immune;Immune response;Immune signaling;Immunization Programs;Immunocompetent;Immunocompromised Host;immunogenic;Immunologic Factors;Immunologics;immunoregulation;in vivo;Infection;inhibitor;Integrins;Interferons;Knock-out;La Crosse virus;Lead;Lectin;Licensing;Long-Term Effects;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measures;Mediating;Medical;Medicine;mouse model;Mus;Natural Immunity;Nausea;Neurologic;neutralizing antibody;Nucleoproteins;Nucleosides;Organ;Oropouche virus;Orthobunyavirus;outbreak response;Outcome;pandemic preparedness;Pathogenesis;permissiveness;Play;Prevalence;prevent;Process;Proteins;prototype;receptor;Receptor Cell;receptor expression;Regimen;Resources;response;RNA vaccine;Role;screening;Serum;Subunit Vaccines;System;Testing;therapeutic development;therapeutic target;transcriptome sequencing;Tropism;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;vaccine platform;Vaccines;vector;Viral;Viral Encephalitis;Viremia;Virginia;Virus;Virus Replication;Work

PROJECT_TITLE: Project 3: Peribunyaviridae Pathogenesis and Vaccine Testing


PI_NAMEs: SEMLER, BERT L (contact)

PROJECT_TERMS: acute flaccid myelitis;Adjuvant;Animal Model;Animals;Anti-viral Agents;Antibodies;Attenuated Vaccines;Biological Assay;Biology;Cardiomyopathies;Cell Line;Cessation of life;combat;comparative efficacy;Coxsackie Viruses;design;design and construction;Development;Disease;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Evaluation;experimental study;Family;Family Picornaviridae;Goals;Human;human pathogen;Human poliovirus;humanized mouse;Immune;Immune response;In Vitro;in vivo Model;Inactivated Vaccines;Infection;Lead;Meningitis;Messenger RNA;Modeling;mouse model;Mus;nanobodies;Neonatal;novel;novel strategies;novel vaccines;Pancreatitis;pandemic potential;pandemic preparedness;Paralysed;Pathogenesis;Pathogenicity;Pathology;Pattern;Phylogenetic Analysis;Poliomyelitis;preclinical evaluation;Predisposition;Proteins;Public Health;RNA vaccine;RNA Viruses;Series;Serotyping;Serum;Severity of illness;Standardization;Structure;Symptoms;Testing;Therapeutic;Transfusion;vaccine candidate;Vaccine Design;vaccine efficacy;vaccine evaluation;vaccine platform;Vaccine Production;vaccine response;vaccine strategy;Vaccines;Viral;viral entry inhibitor;Virus;virus culture

PROJECT_TITLE: Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Signaling through neuronal primary cilia plays a crucial role during early development, but primary cilia persist into adulthood and their role in mature neurons is largely undefined. Recent research has unveiled that ciliary signaling via the neuropeptide somatostatin (SST) can modulate neocortical circuits to potentially stabilize activity by providing network-wide homeostatic feedback to modulate excitatory synaptic strengths. Here I will test this hypothesis by manipulating SST signaling and determining the impact on neocortical function and further provide valuable insights into the underlying cause of cognitive impairment in disorders arising from cilia dysfunction.

PI_NAMEs: WONG, NICOLE FRANCES (contact)

PROJECT_TITLE: Homeostatic Maintenance of Neocortical Excitation-Inhibition Balance by Ciliary Neuropeptidergic Signaling


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Mental Health;Pain Research;Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Primary Health Care;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative In this K24 application, candidate Abby R. Rosenberg, MD, MS, MA proposes to expand her research and mentoring skills to optimize the impact and delivery of promising psychosocial interventions among youth with non-malignant blood disorders. Her research aims are to (1) test the feasibility and acceptability of a community- based, collaborative care model to deliver a positive psychology intervention among teens and young adults with Sickle Cell Disease; (2) leverage the electronic health record to evaluate relationships between social determinants of health and outcomes among children with non-malignant blood disorders; and (3) explore the impact of social determinants of health on psychosocial intervention efficacy using existing data from her R01- funded clinical trials. Her career development goals are to: (1) enhance her skills in collecting and investigating social determinants of health; (2) develop knowledge in dissemination and implementation science, with a focus on community-based adaptation and engagement; and (3) develop skills in using the electronic health record to assess patient-centered outcomes.

PI_NAMEs: ROSENBERG, ABBY R (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Advanced Malignant Neoplasm;Anxiety;Award;Boston;career;career development;Caregivers;Certification;Child;Chronic;Clinic;clinical care;clinical implementation;Clinical Trials;cognitive function;Collaborations;collaborative care;Communities;community collaboration;Country;Dana-Farber Cancer Institute;Data;Data Analyses;Databases;design;Development;Disease;Dissemination and Implementation;dissemination science;Distress;early-career faculty;efficacy testing;Electronic Health Record;Emotional;Enrollment;Environment;evidence base;experience;Family;feasibility testing;Food;Funding;Future;Goals;Hematological Disease;Hemophilia A;high risk;Hospitals;Housing;Impairment;implementation science;improved;improved outcome;Institution;interest;Intervention;Knowledge;Language;Learning;Length of Stay;Life;Malignant Neoplasms;marginalized population;Medicine;Mental Depression;Mental Health;Mentors;Methodology;Modeling;Neighborhoods;next generation;Non-Malignant;novel;Outcome;Pain;Pain interference;Palliative Care;patient oriented research;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Personal Satisfaction;Phase;physical conditioning;pilot test;Population;primary outcome;Process;programs;promote resilience;psychological distress;Psychology;psychosocial;Quality of life;racial bias;randomized trial;Reporting;Research;Research Activity;Research Personnel;resilience;Resources;Science;Scientist;Sickle Cell Anemia;Site;skills;social;social epidemiology;Social Functioning;social health determinants;social stigma;stress management;stress resilience;stressor;success;survivorship;Symptoms;Teenagers;telehealth;Testing;Time;Translating;treatment as usual;Treatment Efficacy;Universities;urgent care;Visit;Washington;Woman;young adult;Youth

PROJECT_TITLE: Collaborative Care to Improve Resilience and Quality of Life among Youth with Non-malignant Blood Disorders

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Age-related macular degeneration (AMD) continues to be a leading cause of irreversible blindness in veterans. This project addresses remaining gaps in AMD prevention and treatment by investigating blood flow to the eye with specialized imaging specifically to identify those veterans at higher risk of vision loss with low blood flow in the eye. This project will determine whether using laser speckle flowgraphy (LSFG) a type of non-invasive imaging that measures blood flow supplying the retina, can detect lower blood flow among patients with age-related macular degeneration. We will also determine how variable these measurements are so that we know what to expect when following veterans’ blood flow over time in the future. This will allow us to identify and monitor veterans who could be candidates for new treatments to increase blood flow to prevent vision loss from advanced AMD.

PI_NAMEs: LINTON, EDWARD F (contact)

PROJECT_TERMS: Acceleration;Address;Age;Age related macular degeneration;age stratification;Agreement;American;Angiography;Area;Arteries;Atrophic;Award;Biometry;Blindness;Blood;Blood capillaries;Blood flow;blood flow measurement;Blood Vessels;career;career development;Case/Control Studies;Caucasians;Choroid;Clinical Research;Clinical Trials;cohort;Cohort Studies;Communication;Complement;Cross-Sectional Studies;Data;Data Science;deep learning;density;design;Development;Disease;Doctor of Philosophy;Dropout;Dryness;Elderly;Endothelin Receptor Antagonist;Engineering;Enrollment;Ensure;experience;Eye;Fellowship;functional restoration;Funding;Future;Genetic;geographic atrophy;Glaucoma;Goals;high risk;Histology;Image;Image Analysis;image processing;Imaging Techniques;Implant;improved;indexing;Individual;Internet;Intervention;Iowa;Lasers;Literature;Location;Longitudinal Studies;longitudinal, prospective study;loss of function;macula;Macular degeneration;Measurable;Measurement;Measures;Mentors;Methods;Modeling;Monitor;Multimodal Imaging;non-invasive imaging;Nonexudative age-related macular degeneration;nonhuman primate;novel strategies;novel therapeutics;Ophthalmologist;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Pathogenesis;Patient Monitoring;Patients;Perfusion;Phase;Photoreceptors;Positioning Attribute;Preparation;preservation;prevent;Prevention;progression risk;Prospective, cohort study;Pythons;Quality of life;Rehabilitation therapy;Research;Research Design;restoration;Retina;Risk;Risk Assessment;Risk Factors;Role;San Francisco;Scientist;Severities;skills;Structure;Structure of retinal pigment epithelium;Study Subject;success;Surgeon;Techniques;Testing;Therapeutic;Thick;Time;Training;translational physician;translational scientist;treatment trial;Universities;Vascular Diseases;Veterans;Vision

PROJECT_TITLE: Exploring the implications of widespread decreases in dynamic blood flow to the retina and choroid in dry macular degeneration

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Lumbar puncture with cytology is the gold standard for confirming the diagnosis of leptomeningeal disease (LMD); however, it is an invasive test and often requires multiple samples to capture circulating tumor cells (CTCs) within the cerebrospinal fluid (CSF). Point-of-care diagnostic devices that could be quickly and simply used by the hospital staff to quantify CTCs would significantly aid in the diagnosis of LMD. Such devices could also be easily integrated with treatment procedures to assess treatment efficacy, which is beneficial as there have been studies that suggest that the concentration of CTCs in CSF can be used as potential outcome measures.

PI_NAMEs: KAMEI, DANIEL T (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Antibodies;aqueous;Arachnoid mater;Bar Codes;Binding;Biological Assay;Brain;Brain Neoplasms;Breast Cancer Cell;burden of illness;cancer cell;catalase;Cell Adhesion Molecules;cell type;Cells;Cerebrospinal Fluid;Clinical;Color;cost;COVID-19;Cytology;Detection;detection method;Devices;Diagnosis;Diagnostic Equipment;Disease;Encapsulated;Epithelial Cells;Equipment;Eye;Flow Cytometry;Gel;Hospitals;Human;Human Resources;Hydrocephalus;Hydrogen Peroxide;Immunoassay;improved;Incubated;Injections;Label;Lateral;lateral line;Leptomeninges;Leukocytes;Liquid substance;Measures;Monitor;nanoGold;nanorod;Neoplasm Circulating Cells;Neoplasm Metastasis;next generation;novel;Outcome Measure;Output;Paper;Patients;Performance;Peroxidases;Phase;Platinum;point of care;point-of-care diagnostics;Pregnancy;Printing;Procedures;Prognosis;PTPRC gene;rapid detection;Rapid diagnostics;real time monitoring;Sampling;Sensitivity and Specificity;Shunt Device;Signal Transduction;Silicates;Spinal Puncture;Survival Rate;System;T-Lymphocyte;Testing;Therapeutic;Thick;Thinness;Training;Treatment Efficacy;user-friendly;Validation;With laterality

PROJECT_TITLE: Novel paper-based diagnostics for the rapid detection and monitoring of leptomeningeal disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J2)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The typhoidal Salmonellas (TS), primarily Salmonella Typhi and Paratyphi A, remain a major cause of global morbidity and mortality. Revitalizing Informal Settlements and their Environments (RISE) is a cluster-randomized controlled trial of community-level upgrades of water, sanitation, and hygiene (WASH) infrastructure currently underway in 24 informal urban settlements in Indonesia and Fiji, two countries at high risk for TS. To inform improved future interventions under different scenarios, the data from this controlled trial, including serosurveys and human and environmental microbiome data, will be used to establish compartmental modeling approaches to predict and assess the impact of WASH interventions on TS transmission.

PI_NAMEs: HOFFMAN, SETH ARI SIM-SON (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: 5 year old;Affect;aged;analytical method;Antimicrobial Resistance;Asia;Bacteriophages;Behavior Therapy;Bioinformatics;Biological;Blood;Calibration;career;Cessation of life;Child;climate change;Clinical Research;Clinical Trials;Collection;Communicable Diseases;Communication;Communities;Community Trial;Computational Biology;cost effective;Costs and Benefits;Country;Data;design;Detection;Disease;disease transmission;Droughts;Effectiveness;Ensure;Environment;Environmental Pollution;Enzyme-Linked Immunosorbent Assay;Epidemiology;Evaluation;Event;Feces;Fiji;Floods;follow-up;Funding;Future;Genome;Genomics;Geographic Locations;Geography;global health;Goals;Health;Hemolysin;high risk;Household;Human;Hybrids;Hygiene;Immunoglobulin A;Immunoglobulin G;Immunologics;improved;Incidence;Indonesia;Infection;infectious disease model;Infrastructure;innovation;Intervention;Kinetics;Knowledge;Laboratories;Lead;low and middle-income countries;mathematical model;Measures;Mentors;metagenome;metagenomic sequencing;Methods;microbiome;Modeling;Molecular;Molecular Analysis;Molecular Biology;Morbidity - disease rate;mortality;novel;Outcome;Participant;pathogenic bacteria;Patients;Performance;Physicians;Population;Predisposition;Prevalence;programs;prospective;public health intervention;Randomized, Controlled Trials;Reproducibility;Research;Resource-limited setting;response;Risk;Risk Factors;RNA;Running;Salmonella;Salmonella infections;Salmonella paratyphi;Salmonella typhi;Sampling;Sanitation;Scientist;Serology;serosurveillance;serosurvey;Shotguns;Site;Surrogate Markers;surveillance network;Surveys;Techniques;therapy design;tool;Training;transmission process;Typhoid Fever;United States National Institutes of Health;Vaccines;wastewater samples;Water;water environment;Work

PROJECT_TITLE: Modeling the Impact of Interventions to Reduce Typhoidal Salmonella Transmission in the Indo-Pacific.

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Genetic Testing;Genetics;Mental Health;Neurosciences;Precision Medicine;Prevention;Rehabilitation;Stroke

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.

PI_NAMEs: DRESANG, HALEY C. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acute;Address;Adjuvant;Age;Alleles;Aphasia;aphasia recovery;Apolipoprotein E;Area;Articulation Disorders;Award;behavior change;Biological Markers;Biological Neural Networks;Brain;brain behavior;Brain-Derived Neurotrophic Factor;career development;Caregiver Burden;Catechol O-Methyltransferase;Chronic;chronic stroke;Clinical;Clinical Trials Design;cognitive recovery;cohort;Comprehension;comprehension deficit;Data;design;Development;Development Plans;Discipline;Disease;Doctor of Philosophy;dorsal visual stream;Education;Ensure;Environment;experience;Faculty;Foundations;Functional Magnetic Resonance Imaging;Future;Genes;Genetic;Genetic Markers;Genetic Polymorphism;Genotype;Goals;Graph;Health;Impairment;improved;indexing;Individual;Individual Differences;Infrastructure;Investigation;investigator training;Ischemia;Joints;K-Series Research Career Programs;Language;Language Disorders;language impairment;Language Therapy;Lead;Learning;learning ability;Left;Lesion;Long term disability;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;member;Mental Depression;Mentors;middle cerebral artery;Middle Cerebral Artery Infarction;Modeling;Molecular;motor recovery;neural network;neurobiological mechanism;Neurobiology;neuroimaging;Neurologic;neurological rehabilitation;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;next generation sequencing;novel;Outcome;Participant;patient oriented;Patients;Pattern;Persons;Phenotype;phonology;post stroke;precision medicine;predictive marker;Process;Production;Prognosis;prognostic;Prognostic Factor;prognostic model;prognostic tool;programs;Psycholinguistics;Quality of life;randomized, clinical trials;Recovery;repaired;Research;Residual state;Retrieval;saliva sample;Scientist;Secure;Semantics;Severities;Site;skills;Social isolation;Speech;Stroke;stroke outcome;stroke patient;stroke recovery;stroke survivor;stroke-induced aphasia;success;System;Testing;therapeutic target;Time;Training;Treatment Efficacy;treatment planning;treatment response;Universities;ventral visual stream;Verbal Learning;Wisconsin;Work

PROJECT_TITLE: Genetic and MRI biomarkers of neuroplasticity predict aphasia recovery and phenotypes

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE (3 sentences maximum) This project will develop technology to drive cancers that are defined by lineage-specific transcription factor overexpression to produce their own anti-tumor therapy. The project will result in the development of a specific therapeutic strategy for non-small cell lung adenocarcinoma, and a platform for the development of further therapies to target other cancer types with different transcription factor dependencies. Localized production of the anti-tumor drug will circumvent the toxicities and short half-life limitations associated with systemic administration of some therapies.

PI_NAMEs: WRANGLE, JOHN M. (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: addiction;adeno-associated virus 9 delivery;anti-tumor drug;Brain;Breast;cancer cell;cancer therapy;cancer type;carcinogenesis;Cells;Cervical;Clinic;Clinical Markers;Dependence;design;Development;Drug Delivery Systems;Ewings sarcoma;Exhibits;experimental study;Factor X;gene therapy;Goals;Growth;Half-Life;Head and neck structure;Homeodomain Proteins;Human;Immunotherapy;In Situ;in vivo;interest;Investigation;Kidney;Liver;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;mouse model;Mus;novel;Oncogenic;Organ;Ovarian;overexpression;Pancreatic Sarcoma;precision drugs;Production;promoter;Prostate;Science;Solid Neoplasm;Stomach;Systemic Therapy;Technology;Therapeutic;Therapeutic Effect;Toxic effect;transcription factor;transgene expression;tumor;tumor growth;Validation;vector;Work

PROJECT_TITLE: Exploiting Lineage-Specific Dependencies in Solid Tumors: Using Transcription Factors to Drive Therapeutic Effect In Situ

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (J1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The acute respiratory distress syndrome (ARDS) is severe respiratory failure due to inflammatory lung injury, and immune regulatory pathways may dictate whether patients will develop progressive disease or recover. Our preliminary data in ARDS patients and using a mouse model of acute lung injury (ALI) revealed a role for one such pathway, IL-33-induction of type 2 immunity, in ALI recovery, with increased levels of an endogenous inhibitor (soluble ST2) of this pathway associated with worse ARDS clinical outcomes. The proposed work uses a mouse model of ALI and genetic tools to define the role of IL-33 signaling, and its regulation by soluble ST2, in lung injury and repair and leverages serial plasma and airway samples from ARDS patients to determine how markers of type 2 immunity predict disease trajectory and may reveal opportunities for early therapeutic intervention.

PI_NAMEs: ALLADINA, JEHAN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Advisory Committees;Algorithms;Allergic Disease;Alveolar;animal data;Animal Model;Animals;Asthma;Award;bench to bedside;Binding;Biological Markers;biomarker identification;Biometry;Caring;Cells;Clinical;Clinical Trials;cohort;cytokine;Data;Dependence;design;Development;Disease;Drug Targeting;Environment;Epithelial Cells;Epithelium;Etiology;experience;Extrinsic asthma;Fellowship;Fibrosis;General Hospitals;Genetic;Goals;Homeostasis;Human;human data;human disease;human model;Immune;Immune response;Immune signaling;Immunity;Immunologic Markers;Immunology;improved;indexing;Inflammation;Inflammation Mediators;Inflammatory;Influenza;inhibitor;injury recovery;insight;Interleukin-13;Interleukin-4;Interleukin-5;knockout animal;Knockout Mice;Lead;Learning;Lung;lung injury;lung repair;Maintenance;Massachusetts;Measures;Mediating;medical schools;Membrane;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;Observational Study;Outcome;outcome prediction;participant enrollment;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Physicians;Plasma;Play;Postdoctoral Fellow;prevent;Production;programs;Progressive Disease;prospective;Protein Isoforms;Proteomics;Publishing;Pulmonary Edema;Pulmonary Fibrosis;Pulmonary Inflammation;receptor;Recovery;Regulation;Regulatory Pathway;repaired;Research;Resolution;Respiratory Failure;Risk Factors;Role;Sampling;Scientist;Sepsis;Severities;Signal Transduction;Skates;skills;Source;Statistical Models;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Training;Training Activity;Transgenic Animals;Translational Research;Validation;Ventilator;Work

PROJECT_TITLE: The Impact of Soluble ST2 on Lung Injury Onset and Resolution

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]