NIH_SPENDING_CATS: Cancer;Infectious Diseases;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PUBLIC RELEVANCE/NARRITIVE The overall poor survival rate of ovarian high-grade serous carcinoma (HGSC) provides a consistent imperative to seek improvements globally. The achievement of this project is expected to recognize HPV infection as a previously neglected preventable risk factor of fallopian tube-derived HGSC, and identify the YAP1-HPV oncogenic alliance as a novel key driver of fallopian tube carcinogenesis. The results derived from proposed studies are expected to improve the survival rate of HGSC by developing new prevention (e.g., vaccination) and early detection (e.g., PsV imaging) strategies.

PI_NAMEs: WANG, CHENG  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Achievement;Animal Model;antagonist;Artificial Insemination;Award;cancer imaging;carcinogenesis;carcinogenicity;Carcinoma;Cell Aging;Cell Cycle Arrest;Cells;clinical application;Data;design;Development;Early Diagnosis;Epithelial Cells;Epithelium;Etiology;Experimental Designs;Fallopian Tube Carcinoma;Fluorescence;Funding;HPV-High Risk;Human;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Image;Imaging technology;Immunization;improved;In Vitro;in vivo Model;Malignant - descriptor;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Modeling;Molecular;mouse model;Mus;Natural Immunity;neglect;neoplastic cell;novel;novel chemoprevention;novel strategies;Oncogenes;Oncogenic;Oncoproteins;Ovarian;Ovarian Serous Adenocarcinoma;Ovary;Papillomavirus;Papillomavirus Transforming Protein E6;Pathologic;Pathway interactions;Pelvic cavity structure;Pharmaceutical Preparations;Physiological;Play;preclinical study;Predisposition;prevent;Prevention;Process;Proteins;Protocols documentation;Publications;Publishing;receptor;Reporter;Research;Retrograde Menstruation;Risk Factors;Role;role model;screening;senescence;Serous;Signal Pathway;Solid;sperm cell;Survival Rate;Testing;tool;Transgenic Animals;Transgenic Mice;transmission process;tumorigenesis;Vaccination;Virion

PROJECT_TITLE: The Hippo Signaling Pathway in High Grade Serous Ovarian Carcinoma

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: OVERALL NARRATIVE The goal of this P01 renewal application is to address the question “What have different countries done to regulate tobacco products and how has this impacted tobacco use behaviors?” To fulfill this goal, we will conduct a series of integrated, multi-disciplinary studies in counties with different tobacco use landscapes, to assess public health policies, industry behavior, and the impact on these forces on the use of cigarettes, nicotine vaping products, and heated tobacco products for the purpose of informing United States public health policies.

PI_NAMEs: CUMMINGS, KENNETH MICHAEL (contact);FONG, GEOFFREY T;HYLAND, ANDREW

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: access restrictions;Address;Adolescent and Young Adult;Adult;Affect;Age Years;Australia;Behavior;Behavioral;Canada;Cigarette;cigarette smoking;cohort;consumer behavior;Country;County;Cross-Sectional Studies;Data;data hub;data management;design;Dissemination and Implementation;Doctor of Philosophy;Emerging Tobacco Products;England;Etiology;experience;Funding Agency;Future;Goals;Health;Health Policy;heated tobacco products;Industry;innovation;International;Intervention;Japan;marijuana legalization;Marketing;Mediation;method development;Methods;Modeling;Monitor;multidisciplinary;New Zealand;Nicotine;nicotine use;operation;Perception;Policies;Policy Analysis;Policy Maker;Population;population health;Population Projection;Price;programs;Public Health;Public Policy;public policy on tobacco;Research;Resource Sharing;response;Scanning;Science;Series;South Korea;Statistical Models;Structure;Surveys;Testing;Tobacco;tobacco control;Tobacco Industry;tobacco products;tobacco regulation;Tobacco smoke;Tobacco use;tobacco user;Translating;trend;United States;uptake;vaping nicotine;vapor;Work;young adult;Youth

PROJECT_TITLE: Predicting and Understanding the Use of Nicotine Products In a Rapidly Evolving Nicotine Marketplace: The International Nicotine Product, Policy, and Market (INPAM) Study


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Natural killer (NK) cells are an important part of the immune system that protects the body by recognizing and killing virally-infected cells and cancer cells, and they carry great potential for use as cancer treatments. Unfortunately, existing NK cell therapies have been unable to efficiently kill tumor cells in cancer patients, who themselves also tend to have poorly functioning NK cells for unclear reasons. This project aims to better understand the mechanisms behind NK cell anti-tumor functions, with the ultimate goal of developing new, enhanced NK cell cancer therapies.

PI_NAMEs: WONG, DEREK PERSEUS (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Activated Natural Killer Cell;Adoptive Cell Transfers;Agreement;Allogenic;anti-cancer;Antibodies;antibody-dependent cell cytotoxicity;Antigen-Presenting Cells;B-Cell Acute Lymphoblastic Leukemia;Binding;Biological Assay;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;Cell Cycle;Cell Line;cell type;Cell-Mediated Cytolysis;Cells;chromatin immunoprecipitation;Cyclin-Dependent Kinase 5;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Cyclins;cytokine;Cytoplasmic Granules;cytotoxic;cytotoxicity;Data;differential expression;Dose;Down-Regulation;efficacy evaluation;Enzymes;Epithelium;exhaustion;Exhibits;experimental study;Exposure to;Face;Family;FCGR3B gene;Functional disorder;Genetic;Goals;graft vs host disease;Granzyme;Hematologic Neoplasms;Histone H1;Human;Immune;immune function;Immune system;Immunologic Surveillance;Immunoprecipitation;improved;In Vitro;in vivo;inhibiting antibody;inhibitor;Innate Immune System;Interferon Type II;Interleukin-2;knock-down;Knock-out;lentivirally transduced;Lymphocyte;Lytic;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;member;Mesenchymal;Molecular;mouse model;Mus;mutant;Natural Killer Cell Immunotherapy;Natural Killer Cell toxicity;Natural Killer Cells;neoplastic cell;Neurons;NK cell therapy;Nuclear;overexpression;Pathway interactions;patient derived xenograft model;Patients;perforin;Phenotype;Phosphorylation;Phosphotransferases;Play;Proline;promoter;protein expression;Protein-Serine-Threonine Kinases;Proteins;receptor;Receptor Inhibition;Reporting;Research;Risk;Role;roscovitine;Serine;Signal Pathway;Signal Transduction;Signaling Protein;small hairpin RNA;Stains;T cell therapy;T-bet protein;T-Cell Activation;T-Lymphocyte;Testing;TGF Beta Signaling Pathway;Therapeutic;Threonine;Time;TNF gene;tool;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;tumor;Tumor Burden;Up-Regulation;Viral

PROJECT_TITLE: Investigating the role of Cdk5 and p35 in natural killer cell cytotoxicity


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE The rise of alternative nicotine delivery products (ANDS), which include nicotine vaporized products (NVPs; also known as e-cigarettes) and heated tobacco products (HTPs), have led to intense debates regarding whether these products might serve to displace cigarette smoking, thus benefiting public health. The proposed ITC Nicotine Product Adult Survey is a longitudinal study (n=18,900) of adult cigarette smokers and ANDS users in 7 countries (United States, Canada, England, Australia, New Zealand, Japan, and Republic of Korea (South Korea)) that differ substantially in the ANDS that are available and in the ways in which their governments have regulated them. This five-year research project—an extension of our ongoing international longitudinal study of ANDS—will provide unique evidence to inform policymakers about the public health impact of these new products and of the policies designed to regulate them.

PI_NAMEs: FONG, GEOFFREY T (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;age group;aged;Alternative Nicotine Delivery Systems;analytical method;Applications Grants;Articulation;Australia;Canada;Cannabis;Characteristics;Cigarette;Cigarette Smoker;cigarette smoking;cohort;Cohort Studies;Consumption;Country;COVID-19 pandemic;Data;design;Electronic cigarette;electronic liquid;England;Environment;Environmental Risk Factor;Evaluation;experience;former smoker;Foundations;Funding;Funding Agency;Future;Gender;Government;Grant;health warning;Heart;heated tobacco products;Income;Industry;innovation;Integration Host Factors;International;Japan;Longitudinal Studies;Manufacturer;Marketing;Measures;Methods;Modeling;New Zealand;Nicotine;Nicotine Dependence;nicotine use;nicotine vapor;Pattern;Policies;Policy Analysis;Policy Maker;Population;Population Assessment of Tobacco and Health;Population Group;programs;Public Health;public policy on tobacco;Quasi-experiment;Relapse;Research;Research Project Grants;Sampling;Science;sex;Smoker;Smoking;smoking cessation;South Korea;Surveys;symposium;System;Taxes;Time;tobacco control;Tobacco Industry;tobacco products;Tobacco use;United States;vaper;vaping;vaping nicotine;vector;Work;young adult;Youth

PROJECT_TITLE: Examining transitions between cigarettes and other nicotine delivery products among adults in countries with different regulatory environments: the ITC Nicotine Product Adult Survey


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE A major limitation of animal models of intestinal cancer is their inability to recapitulate the high mutation (base substitution) rates inherent to human intestinal cancers, which define many aspects of tumor biology and clinical behavior. Here we propose to efficiently overcome this constraint by recapitulating the ultramutator phenotype recently described in a wide range of human malignancies—particularly gastrointestinal cancers—and study the impact of induced inflammation on this novel intestinal cancer model. This project will catalyze the creation of a wide range of intestinal cancer mouse models that are effectively humanized with respect to mutation rate, ennabling a wide range of translational investigations.

PI_NAMEs: CASTRILLON, DIEGO H (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;aged;Alleles;Amino Acid Substitution;Animal Cancer Model;Animal Model;base;Behavior;behavioral response;beta catenin;Biology;Breeding;Cancer Etiology;Cancer Model;Cell division;Cessation of life;checkpoint therapy;Clinical;Colitis;Collaborations;Community Clinical Oncology Program;Cryopreservation;Development;Dextran Sulfate;DNA biosynthesis;DNA Polymerase II;DNA Sequence Alteration;DNA-Directed DNA Polymerase;Endometrial Carcinoma;Exhibits;Frequencies;gastrointestinal;gastrointestinal carcinoma;Generations;Genetic;Genetic Engineering;Genetically Engineered Mouse;genome sequencing;Genomics;Growth;Hereditary Nonpolyposis Colorectal Neoplasms;Histology;Housekeeping;Human;Immune response;improved;Inflammation;Inflammatory Bowel Diseases;Inherited;interest;Intestinal Cancer;Intestinal Diseases;Intestinal Neoplasms;Intestinal Polyposis;Intestines;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;men;Methods;Mismatch Repair;Mismatch Repair Gene Inactivation;model building;Modeling;Monitor;Morphology;mouse model;Mus;Mutation;Mutation Spectra;neoantigens;novel;Organoids;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Polymerase;Process;response;Role;Survival Analysis;Tissues;tool;transcriptome sequencing;translational cancer research;translational model;Translational Research;treatment response;tumor;tumor behavior;Tumor Biology;tumor heterogeneity;tumor progression;whole genome;Woman

PROJECT_TITLE: Polymerase epsilon-based mouse and derived organoid models of intestinal cancer


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative Neuronal network responses to different stimuli are extraordinarily complex. The high complexity of responses, coupled with the large volume of possible neurons involved in recordings, make meaningful analysis extraordinarily difficult. This proposal aims to use Dimensionality Reduction methods to reduce the data from individual neuronal activities to prevalent patterns, making analyses more feasible while still considering every neuronal response recorded.

PI_NAMEs: CARBONERO, DANIEL DAVID (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Academic Training;Affect;Anesthesia procedures;awake;Behavioral;Boston;Calcium;cell type;Cells;collaborative environment;Communication;Complex;Computational Science;conditioned fear;Coupled;Data;Development;dimension reduction;Dimensions;discounting;Engineering;Ensure;Equilibrium;Etiology;Event;excitatory neuron;experimental study;Faculty;fear memory;Frequencies;Grouping;Hippocampus;Image;Individual;individual response;Interdisciplinary Study;Isoflurane;Machine Learning;Mathematics;Memory;memory encoding;memory recall;Mentorship;Methods;Modeling;multidimensional data;Mus;neural;neural network;Neurons;Neurosciences;Optics;optogenetics;Output;Pattern;Problem Solving;Research;response;Scientist;Series;Signal Transduction;Somatosensory Cortex;statistics;Stimulus;Structure;System;Technical Expertise;Time;two-photon;Universities;Work

PROJECT_TITLE: Machine Learning for Analyzing State Dependent Neuronal Network Dynamics


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The ability to use reward value information to guide behavior is critical for adaptive behavior and is dysregulated in alcohol use disorders. The basolateral amygdala - a key neural substrate necessary for tracking reward value and using reward value to guide decision making – is sensitive to disruption by low-dose ethanol exposure. The proposed research will investigate the effects of chronic low-dose ethanol exposure on value-guided decision making and associated changes in the basolateral amygdala.

PI_NAMEs: CURRAN-ALFARO, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Adaptive Behaviors;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol risk;alcohol use disorder;Alcohols;AMPA Receptors;Amygdaloid structure;Anxiety;Area;Atrophic;Behavior;Behavioral;Biological;Brain;career;Chronic;Coupled;Data;Decision Making;Dependence;designer receptors exclusively activated by designer drugs;Detection;Development;Diagnostic;Dissociation;Dose;Ensure;Equilibrium;Ethanol;executive function;Exhibits;experimental study;Exposure to;Fellowship;Female;flexibility;Frequencies;Genetic;genetic approach;genetic manipulation;Glutamate Receptor;Impairment;Individual;Learning;male;Mediating;memory process;Mental Depression;Molecular;motivated behavior;Motivation;Mus;N-Methyl-D-Aspartate Receptors;neural;Neuroanatomy;neurobehavioral;Neurobiology;neurotransmission;Nucleus Accumbens;Outcome;Performance;Population;postsynaptic;Prevention strategy;Process;Qualifying;receptor;receptor expression;Recording of previous events;Regulation;relapse risk;Research;Resources;response;Rewards;Synapses;Testing;Training;Universities;Update;Western Blotting;willingness

PROJECT_TITLE: The effects of low-dose ethanol on reward-value decision making and the basolateral amygdala


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Prevention;Prostate Cancer;Substance Misuse;Urologic Diseases

ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative  Alcohol consumption is associated with increased risk, metastasis, and mortality for prostate cancer (PCa), the second-leading cause of male cancer-related deaths in the United States. This study will offer a novel understanding of the mechanisms underlying alcohol-induced PCa progression and identify potential novel therapeutic strategies for the mitigation of alcohol's effects in PCa.

PI_NAMEs: MACKE, AMANDA JESSIE (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Ablation;Acceleration;Adhesions;advanced prostate cancer;Alcohol consumption;alcohol effect;Alcohols;androgen independent prostate cancer;Androgen Receptor;ATF6 gene;Attenuated;Autophagocytosis;Autophagosome;Binding;Biology;cancer cell;cancer diagnosis;carcinogenesis;cell behavior;Cell membrane;cell motility;Cell surface;Cells;Cessation of life;Combined Modality Therapy;Communication;Correlation Studies;Cytoplasm;Data;Development;Distant;docetaxel;Early Endosome;Endoplasmic Reticulum;endoplasmic reticulum stress;epidemiologic data;Epidemiology;Epitopes;Ethanol;Galectin 3;glycogen synthase kinase 3 beta;Glycoproteins;glycosylation;glycosyltransferase;Golgi Apparatus;HDAC6 gene;Heat-Shock Proteins 90;Hydroxychloroquine;In Vitro;in vivo;inhibitor;insight;Integrin alphaV;Integrins;Interruption;Invaded;Laboratories;Link;lymph nodes;Lysosomes;male;Malignant neoplasm of prostate;Malignant Neoplasms;Mannose;Medial;Mediating;Membrane;migration;Modeling;Molecular;Morphology;mortality;Mus;N-Acetylglucosaminyltransferases;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Organ;Outcome Study;Peptide Hydrolases;Play;prevent;problem drinker;Proliferating;prostate cancer cell;prostate cancer progression;prostate cancer risk;prostate carcinogenesis;Prostatic Neoplasms;Proteins;PSA screening;reconstitution;Research;Resistance;response;restoration;Risk;Role;Route;Screening for Prostate Cancer;therapeutically effective;Tissues;trafficking;tumor;tumor growth;Tumor Promotion;United States

PROJECT_TITLE: The impact of alcohol-induced ATF6-mediated ER stress and Golgi disorganization on pro-metastatic glycosylation of integrins in prostate cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative  Platinum-resistance is the ultimate cause of mortality in OC. Here, we test a hypothesis that chemoresistance emerges due to therapy-induced population-level transcriptional reprogramming. We have identified specific sets of drivers that reprogram naïve cells into the Pt-resistant one. This proposal tests the hypothesis and investigates the molecular drivers of chemoresistance using cutting edge genome editing and single-cell level genome profiling tools in vitro and in vivo using clinical samples. Furthermore, we are testing a clinically relevant promising therapeutic target to overcome chemoresistance and boost anti-tumor immunity.

PI_NAMEs: ADLI, MAZHAR  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute;Architecture;arginine methyltransferase;ATAC-seq;Biology;cancer cell;cancer subtypes;cancer therapy;Carboplatin;Carcinoma;Cell Reprogramming;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromatin;Cisplatin;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;combinatorial;comparative;Data;DNA Damage;DNA Repair;DNA Sequence Alteration;Dose;Enhancers;Epigenetic Process;epigenome;epigenomics;Gatekeeping;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome editing;genome-wide;genomic profiling;Genomics;Goals;Growth;Immunocompetent;improved;In Vitro;in vivo;insight;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measures;Mediating;Modeling;Molecular;mortality;non-genetic;Non-Malignant;novel;novel therapeutic intervention;Operative Surgical Procedures;Ovarian Serous Adenocarcinoma;Pathway interactions;Patients;Platinum;Play;Population;Primary Neoplasm;Prognosis;programmed cell death ligand 1;programs;Publishing;Recurrence;Relapse;Repression;Research;Resistance;response;Role;Sampling;screening;Serous;single-cell RNA sequencing;stem-like cell;Technology;Testing;Therapeutic;therapeutic target;therapeutically effective;tool;transcription factor;transcriptional reprogramming;transcriptome;transcriptomic profiling;transcriptomics;tumor;Tumor Debulking;Tumor Immunity;Tumor Tissue;Up-Regulation;Work

PROJECT_TITLE: Chemo-mediated transcriptional reprogramming in ovarian cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cancer;Childhood Leukemia;Clinical Research;Hematology;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project will evaluate early indicators of abnormal brain development in children undergoing chemotherapy treatment for leukemia. Results from this work will inform development of strategies for screening, remediation, and prevention. This work is important, because few efficacious interventions are available for addressing the long-term burden of the effects of chemotherapy treatment following leukemia.

PI_NAMEs: VAN DER PLAS, ELLEN  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: 6 year old;active method;Acute Lymphocytic Leukemia;Address;Affect;Age;Anterior;axon injury;Behavior;Biological Assay;biomarker identification;Brain;brain abnormalities;Brain Injuries;brain volume;cancer therapy;Cerebrospinal Fluid;chemotherapy;Child;Childhood Acute Lymphocytic Leukemia;Clinical;cognitive neuroscience;comparison control;Continuance of life;Data;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;digital;early childhood;Education;efficacious intervention;Etiology;Evaluation;Executive Dysfunction;executive function;Exhibits;Exposure to;frontal lobe;Functional Magnetic Resonance Imaging;Future;Glial Fibrillary Acidic Protein;Growth;high risk;insight;kindergarten;leukemia;leukemia treatment;Life;Light;Link;Long-Term Survivors;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Medicine;mental function;Mental Processes;mental representation;Metabolic;Metabolism;Methotrexate;Morbidity - disease rate;Myelin;myelination;neurochemistry;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neurofilament;Neuroglia;neuroimaging;neuroprotection;Neuropsychology;Neurosciences;neurotoxic;neurotoxicity;Newly Diagnosed;Nursery Schools;Oligodendroglia;Outcome;Parents;Participant;Patients;peer;Phenotype;Pilot Projects;Population;Prevention;Process;prospective;Prospective Studies;Quality of life;rate of change;remediation;Reporting;Research;Rest;Sampling;screening;single molecule;stressor;success;Survival Rate;Survivors;survivorship;tau Proteins;Technology;Ubiquitin;Vocation;white matter;Work

PROJECT_TITLE: Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Youth and young adults play a central role in the rapidly evolving tobacco and nicotine market. The current study will examine tobacco use, nicotine vaping products, and heated-tobacco products among youth and young adults in three countries with very different policy environments: the US, Canada, and England. The between-country design provides a unique framework for assessing the impact of specific policies, as well as the emergence of novel HTPs and oral nicotine products. Finally, the study is well-positioned to examine broader contextual differences across countries, such as the legalization of cannabis, with direct implications for the vaping and smoking among young people.

PI_NAMEs: HAMMOND, DAVID  (contact)

PROJECT_TERMS: Adult;Age;age group;aged;Canada;Cigarette;cigarette smoking;Country;critical period;Cross-Sectional Studies;Data;Dedications;design;England;Environment;experience;health warning;heated tobacco products;International;Legal;marijuana legalization;Marketing;Measures;Menthol;Methods;Natural experiment;Nicotine;nicotine use;North America;novel;Oral;Outcome;Pattern;Persons;Play;Policies;Policy Analysis;Population;Positioning Attribute;Prevalence;Price;Process;Public Health;public policy on tobacco;rapid growth;rate of change;response;Role;Sampling;Schedule;Series;Smoker;Smoking;Smoking Behavior;smoking cessation;Subgroup;Surveys;Taxation;Testing;theories;Time;Tobacco;Tobacco use;trend;uptake;vaping;vaping nicotine;Variant;young adult;Youth

PROJECT_TITLE: Examining uptake and use patterns of cigarettes and other nicotine delivery products among youth in countries with different regulatory environments: ITC Nicotine Product Youth and Young Adult Survey


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cancer mortality has declined in the U.S., yet striking racial/ethnic and socioeconomic disparities in cancer incidence, mortality, screening, prevention, treatment and survivorship persist. This training program addresses a critical need to train diverse individuals to conduct community-engaged and multi-level, multi- domain interventions to reduce cancer-related health disparities in under-resourced and disadvantaged populations.

PI_NAMEs: ALLEN, MICHELE L (contact);STEPANOV, IRINA

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer health disparity;Training Programs

PROJECT_TITLE: Cancer Related Health Disparities Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Functional assessment of how the ubiquitous transposable elements (TEs) affect human development and health has posed a major challenge. This proposal aims to provide a novel framework to study how interactions between the hitherto “junk” TE sequences can regulate pre-mRNA splicing to affect gene function, and argues that such a mechanism can substantially affect both human development and evolution, and help explain the genetic etiology of human diseases.

PI_NAMEs: XIA, BO  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Affect;Algorithms;Alternative Splicing;Alu Elements;Anatomy;Animal Model;Back Pain;Base Pairing;Biological;Biology;Brachyury protein;Chemistry;Code;Communities;Comparative Genomic Analysis;Congenital Abnormality;Creativeness;Custom;Data;Dedications;Developmental Biology;Disease;DNA Transposable Elements;Doctor of Philosophy;Elements;Embryonic Development;Ensure;Equipment;Etiology;Evolution;Exons;experience;Faculty;Fellowship;Funding;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genome;Genomics;Grant;Health;Hindlimb;Human;Human Development;human disease;Human Genetics;Human Genome;Human Genome Project;human genomics;Incidence;Individual;innovation;Institution;Introns;Junk DNA;Knee Osteoarthritis;Laboratories;Leadership;Limb Development;Locomotion;meetings;Mentors;Modeling;Modernization;mRNA Precursor;multidisciplinary;neonate;Neural Tube Defects;Neural Tube Development;Neurons;novel;Pongidae;prevent;Price;Primates;Principal Investigator;Protein Isoforms;Proteins;Publishing;Recording of previous events;Research;Retrotransposon;RNA Splicing;Science;Spinal Dysraphism;success;Systems Biology;Tail;technology development;Testing;Therapeutic;Training;Work;Writing

PROJECT_TITLE: Transposable Element Interaction and Its Impact on Human Development and Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


NIH_SPENDING_CATS: Biotechnology;Cerebrovascular;Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The blood-brain barrier impedes the effective treatment of nearly all brain disorders, and its dysfunction is a leading cause of death. I propose developing and applying new tools to tag, track, and identify which native proteins and cells in the blood can traverse the blood-brain barrier and learn the rules by which they do so. This will expand many-fold the set of therapeutic pathways into the brain, reveal new targets to block disease- provoking neuroinflammation, and provide a new understanding of how communication across the blood-brain barrier supports brain health.

PI_NAMEs: YANG, ANDREW CHRIS (contact)

PROJECT_TERMS: Adult;Aging;Amino Acids;Binding;Bioinformatics;Biological Models;Biology;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood Proteins;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;Brain Diseases;brain health;career;Carrier Proteins;Catalogs;Cause of Death;Caveolins;cell motility;Cell surface;cell type;Cells;Chemicals;Chemistry;Clathrin;Communication;Contact Tracing;Cues;Dedications;Discipline;Disease;Doctor of Philosophy;Drug Delivery Systems;effective therapy;Endothelial Cells;Endothelium;Engineering;Exposure to;Faculty;faculty mentor;Financial Support;Frustration;Functional disorder;Funding;Goals;Health;Health protection;Immune;in vivo;Inflammatory;innovation;Institution;intercellular communication;Label;Leadership;Learning;Licensing;Ligands;Ligase;Mediating;Mentors;Mentorship;Methods;Microglia;migration;Molecular;Mus;Nature;Nervous System Physiology;Neuroimmune;neuroinflammation;Neurons;Neurosciences;new therapeutic target;Observational Study;Paper;Pathway interactions;Perfusion;Peripheral;Permeability;Physiological;Plasma;Plasma Cells;Plasma Proteins;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Printing;Property;Protein Secretion;protein transport;Proteins;Proteome;Proteomics;receptor;recruit;Reporting;Research;Research Project Grants;response;Route;Secure;senior faculty;Signal Transduction;Site;Students;Support System;synthetic biology;T-Lymphocyte;targeted delivery;Techniques;Therapeutic;Tight Junctions;tool;Tracer;Training;transcytosis;Transferrin;transmission process;undergraduate student;Universities

PROJECT_TITLE: Molecular tools to decipher communication across the blood-brain barrier


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Kidney Disease;Nutrition

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Potassium deficiency increases rates of chronic kidney disease (CKD), an illness that has a worldwide prevalence of 10-15% and claims over 130,000 lives annually in the US. Total body control of potassium balance involves both the kidneys and skeletal muscle with potassium channels in both organs being key molecular regulators of this process. This study aims to understand mechanisms by which potassium deficiency affects kidney epithelial cells and macrophages in the progression of CKD and the role of potassium channels in this process; the overall goal of this project is to identify novel CKD treatment targets in both the kidneys and skeletal muscle.

PI_NAMEs: TERKER, ANDREW S. (contact)

PROJECT_TERMS: Academic Medical Centers;Acidosis;Address;Affect;Animals;Basic Science;Biochemical Pathway;cell injury;Cell Physiology;cell type;Cells;Cellular biology;Cessation of life;Chronic Kidney Failure;Clinical Medicine;clinical practice;Communities;Consumption;Data;dietary;Dietary Potassium;Disease Progression;Dominant-Negative Mutation;effective therapy;Electrolytes;Electrophysiology (science);Epithelial Cells;epithelial injury;Equilibrium;Excretory function;extracellular;Faculty;Family member;Funding;Gene Expression;Goals;Homeostasis;Immune;Inflammation;Inflammation Mediators;Inflammatory;Injury;Injury to Kidney;innovation;Institution;Intake;Internal Medicine;International;Kidney;Kidney Diseases;kidney epithelial cell;kidney metabolism;Laboratories;Link;Macrophage;Mediating;Mediator;Membrane;Metabolic;Metabolism;Molecular;Molecular Biology;Muscle;Muscle Cells;Muscle Fibers;novel;novel strategies;Operative Surgical Procedures;Organ;Outcome;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;Phenotype;Physiology;Plasma;Population;Population Study;Positioning Attribute;Potassium;Potassium Channel;Potassium Deficiency;Prevalence;Process;programs;Proteins;Renal function;Research;Research Personnel;Residencies;Role;sensor;Services;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;Skeletal Muscle;Sodium;Testing;Therapeutic;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Innovative therapeutic approaches to treat chronic kidney disease


PHR: NARRATIVE The tobacco landscape has changed significantly in terms of products and policy response, with the response to those policies potentially engendering illegal tobacco purchases. This project will experimentally examine the effects of tobacco marketplace expansion (e.g., novel tobacco/nicotine products), new potential policies (e.g., reduced nicotine content) that may result in illegal purchasing, and strategies to decrease illegal purchases (i.e.., health communications, availability of nicotine replacement therapy, and penalties) among diverse users across different countries. The ultimate goal of this project is to inform tobacco regulation, reduce tobacco-related harm, and improve public health.

PI_NAMEs: FREITAS LEMOS, ROBERTA  (contact)

PROJECT_TERMS: abuse liability;Address;Adult;Age;age stratification;behavioral economics;Canada;Cigarette;Cigarette Smoker;cohort;combustible cigarette;Country;Data;Dependence;Development;England;Environment;experience;experimental study;Generations;Goals;Grant;Health;health communication;heated tobacco products;improved;Individual;innovation;Intention;International;Knowledge;Laboratories;Laboratory Finding;Legal;low nicotine content cigarette;Marketing;Measures;Menthol;Methodology;Methods;Modeling;Nicotine;nicotine replacement;nicotine use;non-cigarette tobacco product;novel;Outcome;Participant;Pattern;Policies;Policy Analysis;policy implication;population health;Price;Public Health;public policy on tobacco;Race;Reaction;Regulation;Research;response;Risk;Role;Sampling;Severities;sex;Smoking;Socioeconomic Status;Surveys;Tobacco;tobacco control;tobacco products;tobacco regulation;Tobacco use;tobacco user;uptake;vaping nicotine;young adult

PROJECT_TITLE: The Experimental Tobacco Marketplace (ETM)


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Radiopharmaceutical therapy (RPT) is a promising alternative to chemo- and biologic- therapy. RPT exploits pharmaceuticals, such as radioiodine, that are concentrated by tumor cells to deliver targeted radiation and is complementary to XRT. Combining XRT with RPT (e.g., as opposed to chemotherapy) allows a precise determination of potential toxicity to normal organs since both modalities involve radiation whose effects on normal tissues can be quantified and predicted by treatment planning.

PI_NAMEs: HOBBS, ROBERT FRANCOIS;LADENSON, PAUL W;SGOUROS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;absorption;Address;Area;Binding;Biological Response Modifier Therapy;cancer cell;Cancer Patient;cancer therapy;cell killing;Characteristics;chemotherapy;clinical implementation;Clinical Trials;cloud based;Combined Modality Therapy;Commercial grade;commercialization;Computer software;Data;Development;Digital Imaging and Communications in Medicine;Disease;Disparate;Disseminated Malignant Neoplasm;Dose;dosimetry;Elements;Endocrinology;Engineering;Epithelium;experience;FDA approved;Grant;Image;improved;individual patient;Industrialization;industry partner;Intellectual Property;interest;Licensing;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Marketing;Medical Oncology;medical schools;member;Methodology;Methods;Modality;multi-arm trial;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Organ;Output;Patients;Pharmacologic Substance;Phase;Phase I Clinical Trials;Physics;Prediction of Response to Therapy;Qualifying;Radiation;radiation delivery;Radiation Oncology;Radiation therapy;Radiation Tolerance;Radioactive;Radioactive Iodine;radioiodine therapy;Radiopharmaceuticals;reconstruction;Recording of previous events;Safety;safety and feasibility;safety assessment;single photon emission computed tomography;software development;Software Tools;Solid;Solid Neoplasm;success;System;targeted delivery;Therapeutic;Thinking;thyroid neoplasm;Tissues;tool;Toxic effect;treatment optimization;Treatment outcome;treatment planning;tumor;United States National Institutes of Health;Universities;uptake;Widespread Disease;Work

PROJECT_TITLE: Combination Radiopharmaceutical Therapy and External Beam Radiotherapy


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Nanotechnology;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PI_NAMEs: BARATTA, JOHN ;BOZKURT, ALPER ;HU, XIAOGANG ;SHEN, XIPENG ;ZHU, YONG  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Ankle;arm;Attention;Cellular Phone;Chronic;Clinic;Clinical;Communication;Communities;community living;community setting;Contralateral;cost;daily functioning;Data;data acquisition;design;Development;Devices;Diagnosis;disability;Disabled Persons;elastomeric;Elastomers;Elbow joint structure;Electrodes;Electronics;Exhibits;Extensor;Feedback;Fingers;Flexor;Friends;Goals;grasp;Health;Healthcare;Home;Impairment;improved;Independent Living;indexing;Individual;innovation;Instruction;Internet;Joints;kinematics;Knee joint;Leg;Limb structure;Lower Extremity;manufacturing cost;Measurement;Methods;Minor;mobile application;Monitor;Motor Activity;motor impairment;multimodality;Muscle;nanomaterials;nanowire;National Institute of Child Health and Human Development;Nature;neuromuscular system;novel;operation;Outcome;Performance;Personal Satisfaction;Persons;Physical activity;Population;post stroke;Printing;Process;Protocols documentation;Recovery of Function;Rehabilitation therapy;Reporting;Research;Sampling;Scheme;sensor;Signal Transduction;Silver;smartphone application;Stroke;stroke rehabilitation;stroke survivor;System;telerehabilitation;therapeutically effective;tool;Training;transmission process;United States;Upper Extremity;user-friendly;wearable device;wearable sensor technology;wireless transmission;Work;Wrist joint

PROJECT_TITLE: SCH: A personalized wearable rehabilitation sensing system for stroke survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE With an aging population, the need for oncology services continues to increase. This Research Training Program in Surgical Oncology addresses a critical need to help meet the future demands for training the next generation of surgical oncologists to pursue academic careers, become physician-scientists or clinician investigators, and translate research discoveries to clinical practice.

PI_NAMEs: MERCHANT, NIPUN B. (contact)

PROJECT_TERMS: Research Training;Surgical Oncology

PROJECT_TITLE: Research Training in Surgical Oncology


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative We propose to create a complete training resource including content and both online and offline courses to improve cancer informatics knowledge throughout the research enterprise. The project will create an informatics training network hosted at www.itcrtraining.org that can be used by everyone from community members, to basic scientists, to ITCR tool developers, to medical doctors, to principal investigators to improve their knowledge of informatics.

PI_NAMEs: GRIFFITH, MALACHI ;GRIFFITH, OBI L.;JEREMIAH, ROHAN DEXTER;LEEK, JEFFREY T. (contact);WRIGHT, CARRIE

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Academia;Address;Adoption;anti-cancer research;Cancer Center;citizen science;Clinic;Clinical;Communities;community college;Computer software;cost;Data;Data Analytics;Data Collection;Data Science;Data Storage and Retrieval;Documentation;Education;education resources;Educational process of instructing;Event;Exercise;experience;Explosion;Funding;Future;Galaxy;Geography;Goals;Heart;Historically Black Colleges and Universities;Home;Image;improved;Informatics;informatics tool;informatics training;Institution;instructor;interest;Knowledge;Learning;learning materials;lectures;Licensing;literacy;Location;Malignant Neoplasms;Marketing;massive open online courses;Measurement;Medical;meetings;member;Minority-Serving Institution;multimodality;online course;open source;outreach;Persons;Phase Transition;Principal Investigator;programs;prototype;Provider;Reproducibility;Research;Research Personnel;Resources;Scientist;Site;skills;software development;Speed;success;Technology;tool;Trainers Training;Training;training opportunity;United States National Institutes of Health;usability

PROJECT_TITLE: Scalable multi-mode education to increase use of ITCR tools by diverse analysts


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Genetic Testing;Genetics;Nanotechnology;Women's Health Research

ORG_CITY: LAWRENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Narrative In spite of wide-scale mammography screening efforts, breast cancer is still the second leading cancer killer among females in the US. For those diagnosed with Stage I/II breast cancer, patients are subjected to molecular subtyping to determine the proper course of therapy, which is commonly performed from a solid tissue biopsy. In this R21 project, a highly innovative technology will be generated that builds from the PAM50/Nanostring assay for subtyping breast cancer patients using mRNA expression. The technology uses a plastic-based nanosensor to read electrically distinct reporters targeting a particular mRNA. The mRNA required for the technology is sourced from extracellular vesicles (i.e., liquid biopsy).

PI_NAMEs: SOPER, STEVEN ALLAN (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adjuvant Therapy;Adopted;Affinity;American Cancer Society;Architecture;Avidin;Binding;Biological Assay;Biopsy;Biopsy Specimen;Biotin;Breast Cancer Patient;cancer diagnosis;Cancer Etiology;cancer subtypes;Cells;Cessation of life;Characteristics;Clinical;Clinical Research;Code;Collection;Complex;Detection;detection limit;Devices;Diagnosis;Diameter;Disease;DNA;Elements;Engineering;epithelial to mesenchymal transition;Epithelium;Equipment;ERBB2 gene;Expression Profiling;extracellular vesicles;Female;fibroblast activation protein alpha;Fluorescence;Fluorescent Dyes;Formalin;gene panel;Genes;Geometry;Glass;Harvest;Heterogeneity;Image;Immobilization;Injections;innovation;innovative technologies;instrument;Length;Light;liquid biopsy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Measures;Mesenchymal;Messenger RNA;meter;Microfluidic Microchips;Microfluidics;minimally invasive;Molds;Molecular;molecular imaging;molecular subtypes;mRNA Expression;nano-string;nanochannel;nanofluidic;nanometer;nanopore;nanosensors;Nature;neutravidin;Newly Diagnosed;Nucleic Acids;Optics;Outcome;Paraffin Embedding;Patients;Physiologic pulse;Plasma;Polymethyl Methacrylate;Primary Neoplasm;Process;Proteins;receptor;Relapse;Reporter;Reporting;RNA;Sampling;Secure;sensor;Series;Side;single molecule;Site;Slide;Solid;Source;standard of care;Streptavidin;Stretching;Structure;Surface;TACSTD1 gene;Techniques;Technology;Testing;Time;Tissue Embedding;Tissue Sample;Tissues;Treatment Protocols;Tube;tumor;Vertebral column;Width;Women's mortality;Work

PROJECT_TITLE: Molecular Sub-typing Breast Cancer Patients using a Liquid Biopsy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In The Ohio State University Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) project, we will address multiple levels (system, provider or patient) to referral to clinical trials, as well as multiple aspects within each level. The project will demonstrate academic institutions are able to leverage resources and work with community hospitals and NCI-NOCRP sites to increase referrals and ultimately accrual to clinical trials in communities where people live.

PI_NAMEs: LEE, CHERYL T.;PASKETT, ELECTRA D. (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Address;African American;Agreement;Area;bilingualism;biomedical referral center;black patient;Black race;Breast;Cancer Center;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer referral center;Catchment Area;Centers for Population Health;Chest;Clinic;Clinical Cancer Center;clinical practice;clinical trial protocol;Clinical Trials;Communities;Community Clinical Oncology Program;Community Health Aides;Community Hospitals;Community Outreach;community partners;community partnership;Community Practice;Comprehensive Cancer Center;control trial;County;design;Detection;Disease;Disparity;disparity gap;Education;Eligibility Determination;Enrollment;ethnic minority;Ethnic Population;experience;Fostering;gastrointestinal;Genitourinary system;Goals;health disparity;Health system;Healthcare Systems;Hematology;Hispanic;Hospitals;improved;Institution;Intervention;Intervention Trial;Left;Malignant Neoplasms;member;Methods;Minority;minority communities;Modality;Modeling;National Clinical Trials Network;Ohio;Outcome;outreach;participant enrollment;patient navigator;Patients;Pattern;Persons;Phase;Population;Population Group;Prevention trial;primary outcome;Process;programs;Provider;Public Health;racial minority;racial minority population;racial population;Research;Resources;Risk;secondary outcome;Site;success;System;Theoretical model;Therapeutic Intervention;treatment trial;Underrepresented Populations;Universities;Work

PROJECT_TITLE: OSUCCC CUSP2CT


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Although clinical tomosynthesis systems for breast cancer screening are designed to scan in only one direction (left-to-right), we have built a next-generation tomosynthesis system which can also scan in the posteroanterior or perpendicular direction. The aim of this grant is to perform a pilot study of this new imaging technology with volunteers, using radiologists' interpretations of the images in combination with clinical follow-up data to determine if the new scanning method would facilitate a lower call-back rate without reducing sensitivity. We will also perform quantitative analyses of the segmented breast volume to demonstrate that there is suppression of cone-beam artifacts, and will calculate density and texture measures as surrogate metrics of detectability and tissue superposition effects which we expect to be improved by the new scanning method.

PI_NAMEs: ACCIAVATTI, RAYMOND JOSEPH (contact)

PROJECT_TERMS: 3-Dimensional;Abbreviations;Adipose tissue;Anisotropy;Anterior;Anxiety;Benign;Biopsy;Breast;Breast Cancer Detection;breast density;breast imaging;calcification;Callback;Cancerous;Caring;Cephalic;Chest wall structure;Clinical;Clinical Data;Clinical Trials;Cone;Data;Dedications;density;design;Diagnosis;Diagnostic Imaging;Digital Breast Tomosynthesis;Electromagnetic Energy;Entropy;experience;follow-up;Generations;Grant;Health Care Costs;High Risk Woman;Human;human subject;Image;Image Analysis;Imaging technology;improved;infancy;Laplacian;Laws;Left;Localized Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Mammographic screening;Mastectomy;Measures;Medical;Memory;Methods;Modeling;Morphologic artifacts;Motion;next generation;Noise;Participant;Performance;Pilot Projects;Probability;Radiation Dose Unit;Radiation exposure;radiologist;Randomized;Reader;Reading;Receiver Operating Characteristics;reconstruction;recruit;Research;Resolution;response;ROC Curve;Scanning;Schedule;screening;Shapes;Side;Signal Transduction;Specificity;Specimen;Stress;Structure;System;Systems Development;Texture;Three-dimensional analysis;Time;Tissues;tomosynthesis;Translations;trend;tumor;ultra high resolution;volunteer;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Next-Generation Tomosynthesis Pilot Study

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE The purpose of the Administrative Core (AC) is to provide and integrate scientific leadership, administrative support, and fiscal management, for the entire Program Project. The three primary functions of the AC include: 1) project management; 2) scientific planning, coordination of activities across projects, and evaluation; and 3) dissemination of research findings.

PI_NAMEs: CUMMINGS, KENNETH MICHAEL (contact)

PROJECT_TERMS: Advisory Committees;American;Award;Communication;Country;Data;Department chair;Doctor of Philosophy;Evaluation;evidence base;experience;Feedback;Funding;General Population;Government;Grant;Health;Health behavior;health organization;Health Policy;Institution;International;international health organization;Lead;Leadership;Logistics;Longitudinal Studies;Manuscripts;Marketing;Measures;Medical;meetings;member;Monitor;National Institute of Drug Abuse;Nicotine;nicotine use;operation;Peer Review;Pilot Projects;Policies;Policy Maker;Population Assessment of Tobacco and Health;Production;programs;Progress Reports;Protocols documentation;Public Health;Public Opinion;public policy on tobacco;Publications;Publishing;recruit;Reporting;Research;Research Personnel;Role;Services;skills;South Carolina;System;tobacco control;Tobacco Control Research;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURBAN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF KWAZULU-NATAL

PHR: PROJECT NARRATIVE An unacceptably high proportion of newly diagnosed colorectal cancer (CRC) patients in KwaZulu-Natal (KZN), South Africa (SA) will fail to engage in oncology care (FEOC), thereby complicating oncologists’ and oncologic surgeons’ efforts to effectively manage CRC disease in this resource-limited setting. A novel clinical prediction rule (CPR) will be developed that will allow for specific CRC patients who are at higher risk of FEOC to be identified and efficiently targeted for resource-intensive strategies which seek to reduce FEOC rates. The CPR will be an important first step in tackling the high FEOC rates amongst newly diagnosed CRC patients in KZN, SA and will ultimately contribute toward improving both CRC disease management and patient outcomes in this setting.

PI_NAMEs: MOODLEY, YOSHAN  (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Address;Adherence;advanced disease;Advisory Committees;Algorithmic Analysis;Applications Grants;Appointment;Artificial Intelligence;Award;Biopsy;Books;burden of illness;care systems;career development;Caring;Characteristics;Clinic;Clinic Visits;Clinical;clinical practice;clinical predictors;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer screening;Communities;comorbidity;Competence;Country;Coupled;Data;Data Collection;data registry;Data Sources;Decision Making;design;Diagnosis;Disease;Disease Management;electronic data;electronic registry;Electronics;Enrollment;Epidemiologist;Failure;feature selection;flexibility;Funding;Future;Government;gradient boosting;Grant;Health Care Sector;Healthcare Systems;high risk;improved;Intention;Intervention;Laboratories;Literature;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning method;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mentors;Meta-Analysis;model development;mortality;neural network;Newly Diagnosed;novel;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Outcome Study;patient registry;Patient-Focused Outcomes;Patients;Population;predictive modeling;Prevention strategy;Program Development;prospective;Public Health;Public Sector;Publishing;Questionnaires;random forest;Research;Research Assistant;Research Personnel;Resource-limited setting;Resources;Review Literature;scale up;screening;screening program;sociodemographics;South Africa;South African;Specialist;Statistical Data Interpretation;statistics;support vector machine;Surgical Oncologist;Surveys;systematic review;Time;tool;Training;Universities;Validation;Visit;Vocational Guidance

PROJECT_TITLE: A clinical prediction rule for identifying South African colorectal cancer patients who will fail to engage in oncology care

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE The Data Management Core (DMC) will design and oversee the data collection for the surveys, administer data collection for the adult cohort, and collect data for the Emerging Products Core and the Experimental Tobacco Marketplace. The DMC will continue to produce data sets for users, to manage a secure repository of data and data access system, and to maintain a database of policies related to products delivering nicotine. Questionnaire specialists will provide support to all projects and cores around instrument development and documentation, ensuring comparability of measures across studies, and DMC personnel will perform analyses for papers and presentations, estimate parameters as input to the modelling project, provide advice and technical assistance, and serve as a hub for the efforts of analysts and data specialists of the projects.

PI_NAMEs: THOMPSON, MARY  (contact)

PROJECT_TERMS: Adult;Biostatistical Methods;cohort;Collection;Communication;computerized data processing;Consultations;Country;Data;data access;data access system;data cleaning;Data Collection;data integration;data management;data repository;Data Set;data sharing;Databases;design;Device or Instrument Development;Documentation;Ensure;Health behavior;Human Resources;interest;International;Marketing;Measures;method development;Methods;Modeling;Monitor;Nicotine;nicotine use;Paper;Parameter Estimation;Policies;Population Control;Preparation;Production;Protocols documentation;Questionnaire Designs;Questionnaires;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;response;Role;Sampling;Secure;Services;simulation;Site;Source;Specialist;Surveys;synergism;Testing;Time;Tobacco;tobacco control;Tobacco use;Weight;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE The Emerging Products Core (EPC) will provide timely data to Project Leaders about the state of the tobacco product market. Using multiple data sources, the EPC will identify and track emerging products in each country. It will then use physical and chemical analyses of those products to examine differences relevant to regulations.

PI_NAMEs: O'CONNOR, RICHARD J (contact)

PROJECT_TERMS: Adopted;Advertising;Calibration;Categories;Characteristics;Chemicals;Cigarette;combustible cigarette;Country;Data;Data Sources;design;Development;Emerging Communicable Diseases;Future;Goals;Grant;heated tobacco products;improved;Ingredients and Chemicals;International;Internet;Japanese;JUUL;Label;Legal patent;Marketing;Modeling;multiple data sources;Nicotine;nicotine use;novel;Pattern;Perception;Performance;Policies;preference;Price;Production;Regulation;Reporting;Research;Research Personnel;Sales;Scanning;Security;Smoker;social media;Study models;Surveys;Testing;Tobacco;Tobacco Industry;tobacco products;Twitter;uptake;vaping;Youth

PROJECT_TITLE: Emerging Products Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Obesity rates are rising worldwide, and we urgently need to better understand the specific crosstalk by which adipose (fat) tissue can drive colon tumorigenesis and how to intercept these interactions. We propose a unique transdisciplinary approach involving studies in humans complemented by parallel mouse models of colon cancer to investigate how the adipose tissue communicates with colon epithelial cells to drive carcinogenesis. The combination of a unique, well-established cohort of colon cancer patients and state-of-the- art experimental model systems will accelerate translation of our discoveries into clinical application.

PI_NAMEs: HURSTING, STEPHEN D;ULRICH, CORNELIA M (contact)

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adipose tissue;African American;Azoxymethane;Biochemical;Biological;Biological Markers;Biological Models;biomarker panel;Body mass index;Cancer Burden;Cancer Etiology;Cancer Model;Cancer Patient;cancer risk;cancer type;Candidate Disease Gene;carcinogenesis;Caucasians;Cessation of life;Clinical;clinical application;Clinical Research;clinically relevant;Coculture Techniques;cohort;Cohort Studies;Colon;colon cancer patients;Colon Carcinoma;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;Colorectal Neoplasms;Communication;cost effective;CRISPR screen;cytokine;Data;data integration;Development;diet-induced obesity;Disseminated Malignant Neoplasm;Epidemiology;epidemiology study;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Etiology;Experimental Models;experimental study;Fatty acid glycerol esters;Fibrosis;Gene Expression;Gene Expression Profile;Genes;Goals;Human;Hypertrophy;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;innovation;Intercept;interdisciplinary collaboration;Lead;Light;Link;Malignant Neoplasms;Measures;Mediating;Metabolic;metabolic profile;metabolomics;Modeling;Molecular Target;mouse model;Mus;neoplastic cell;novel;novel strategies;Obese Mice;Obesity;Obesity associated cancer;Obesity Epidemic;organoid transplantation;Organoids;overexpression;pandemic disease;Pathway interactions;Patients;Persons;Population;pre-clinical;Pre-Clinical Model;preclinical study;Prevention approach;Prevention strategy;prospective;Proteins;Public Health;Race;Rectal Cancer;Research;Research Design;Resources;response;Risk Factors;Role;Serum;Sex Differences;Signal Transduction;synergism;Testing;Thinness;Tissue Sample;Tissues;transcriptome sequencing;transcriptomics;Translations;tumor;tumor progression;Tumor Tissue;United States;Validation;Visceral;WNT Signaling Pathway

PROJECT_TITLE: Adipose tissue-colorectal tumor cross-talk: new targets for breaking the obesity-cancer link

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-B(02)M]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal seeks funds to develop and operate a 5-year series of summer workshops to train a diverse group of early-career scholars on the use of data from the Fragile Families and Child Wellbeing Study. The workshops will present substantive findings from the data, discuss the measurement of key constructs for population research, and provide hands-on training with the Fragile Families data. In so doing, the proposed workshop will support a cohort of emerging scholars and further the understanding of behavioral and social functioning relevant to the health and wellbeing of adolescents and families.

PI_NAMEs: GARFINKEL, IRWIN ;MINCY, RONALD BERNARD (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: 15 year old;Address;Adolescent;Adolescent and Young Adult;adolescent health;Affect;Age;Area;Attention;Behavioral;biomedical scientist;Birth;Book Chapters;Books;Brain;career;Child;child physical development;Child Rearing;Child Welfare;Cities;Code;cognitive development;cohort;Collaborations;Collection;college;comparison group;Couples;Crime;Criminal Justice;Data;data access;Development;Discipline;Disparity population;DNA Methylation;economic disparity;Economics;Education;Educational workshop;Environmental Risk Factor;Ethnic Origin;Family;Fathers;Funding;gene environment interaction;Generations;Genetic;genetic makeup;Genetic Predisposition to Disease;Health;Health behavior;health disparity;high school;Hispanic;improved;interest;Interview;journal article;Learning;Literature;Measurement;Measures;member;Mentorship;Methods;Mothers;Neighborhoods;Outcome;Paper;Parents;Participant;Performance;Personal Satisfaction;physical conditioning;Play;Population;population based;Population Research;Probability Samples;Publications;racial disparity;racial minority;Research;Research Design;Research Personnel;Resources;response;Risk Behaviors;Role;saliva sample;Sampling;Schools;Science;Scientist;senior faculty;Series;Sleep;social;Social Behavior;Social Functioning;Surveys;tool;Training;training data;United States National Institutes of Health;Unmarried;urban children;Urban Developments;Violence;Well in self

PROJECT_TITLE: Fragile Families Summer Data Training Workshop Series 2021-2025

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary diseases account for approximately four million deaths per year in the United States. There is an acute need to train dedicated scientists who will form the future workforce empowered to make discoveries which lead to the reduction in death and disability from pulmonary disease. The Indiana University School of Medicine “IU Training Program in Molecular Physiology and Clinical Mechanisms of Lung Disease,” provides state-of-the-art research training for M.D. and Ph.D. scientists, adult and pediatric, in both laboratory-based and clinical studies, with the goal of training the next generation of leaders in the field of pulmonary disease research across the lifespan.

PI_NAMEs: MACHADO, ROBERTO F. (contact);TEPPER, ROBERT S.

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE – Overall Glioblastoma (GBM) is one of the most frequent cause of cancer death in children and young adults and is the most common malignant primary brain tumor in adults. Moreover, current therapy is incapacitating and is limited by non-specific toxicity to systemic tissue or surrounding brain. Focused on development of a novel immunotherapeutic against GBM called 6-thio-dG, the research proposed will investigate and integrate the mechanisms behind the action of this drug, and takes basic science to the next level of clinical translation in an early human trial.

PI_NAMEs: ASHLEY, DAVID M. (contact);SHAY, JERRY WILLIAM

PROGRAM_OFFICER_NAME: ESPEY, MICHAEL G

PROJECT_TERMS: adaptive immune response;Address;Adult;Adult Glioblastoma;Animals;anti-tumor immune response;Basic Science;biobank;Bioinformatics;Biological;Biological Markers;Biological Models;Biotechnology;blood-brain barrier penetration;Brain;Brain Neoplasms;Cancer Etiology;CD8-Positive T-Lymphocytes;chemotherapy;childhood cancer mortality;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;Communication;Cross-Priming;Data;Decision Making;Dendritic Cells;Deoxyguanosine;design;Development;Diagnosis;DNA;DNA Damage;Doctor of Philosophy;drug action;Drug Targeting;effectiveness study;Eligibility Determination;Ensure;Excision;Experimental Designs;fighting;Future;Glioblastoma;Human;Immune;immune checkpoint blockade;immunogenic;Immunologic Adjuvants;Immunotherapeutic agent;in vivo;Infrastructure;Innate Immune Response;innovation;Institution;Interferons;Leadership;Letters;Link;Malignant - descriptor;Mediating;Medical center;Modeling;Monitor;mouse model;neuro-oncology;novel;novel strategies;Office of Administrative Management;operation;Operative Surgical Procedures;Organoids;overexpression;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;Phase 0 Clinical Trial;Pilot Projects;Population Heterogeneity;pre-clinical;preclinical development;preclinical efficacy;Primary Brain Neoplasms;Publishing;Reporting;Research;Resistance;Resources;response;response biomarker;Safety;Sampling;Scientist;screening;Slice;Solid Neoplasm;Somatic Cell;Stratification;success;synergism;Telomerase;telomere;temozolomide;Texas;Therapeutic;Time;Tissues;Toxic effect;translational physician;Translational Research;translational scientist;tumor;Tumor Escape;Universities;Work;young adult

PROJECT_TITLE: 6-thio-2'-deoxyguanosine: A Novel Immunogenic Telomerase-Mediated Therapy in Glioblastoma - A Duke and UTSW Collaboration


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

PI_NAMEs: ASHLEY, DAVID M. (contact)

PROJECT_TERMS: Accounting;Address;Adult Glioblastoma;biobank;Bioinformatics;Biological;Biological Markers;Budgets;Clinical Trials;Collaborations;Communication;conflict resolution;Data;data integrity;data management;Data Provenance;Deoxyguanosine;Drug Targeting;early phase clinical trial;Ensure;Evaluation;Expenditure;Fostering;Funding;Future;Glioblastoma;Goals;Guidelines;immunogenic;Infrastructure;innovation;Institution;Manuscripts;Mediating;meetings;Monitor;novel;novel strategies;Occupational activity of managing finances;Office of Administrative Management;operation;patient population;Patients;Pilot Projects;Policies;preclinical development;Preparation;Process;Productivity;professor;Program Evaluation;Publications;quality assurance;Regulation;Reporting;Research;Research Personnel;Research Subjects;Resource Sharing;Resources;Schedule;Science;Site;Specimen;Structure;Telomerase;telomere;Therapeutic;United States National Institutes of Health;Universities;Visit


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE (See instructions): Postpartum hemorrhage, the loss of one liter of blood or more within 24 hours after birth, is the leading  cause of maternal death despite being largely preventable with early diagnosis and treatment. Although not  currently monitored, immediate physiologic changes help stabilize the patient and likely provide a window  of opportunity for treatment at early stages of hemorrhage when simple treatments are most effective. The  goal of this proposal is to develop a new wearable light-based device that accurately detects these  compensatory changes associated with postpartum hemorrhage, thereby facilitating improved maternal  health outcomes with early treatment.

PI_NAMEs: O'BRIEN, CHRISTINE M (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Affect;Award;Birth;Blood;Blood Cells;Blood flow;Blood Pressure;Blood specimen;Blood Vessels;Blood Volume;Cesarean section;Cessation of life;Compensation;Complex;constriction;Data;Databases;Death Rate;design;Developed Countries;Devices;Diagnosis;diagnostic algorithm;Discipline of obstetrics;Disease;Early Diagnosis;Early treatment;ergonomics;experimental study;Family suidae;Goals;Heart Rate;Hematocrit procedure;Hemodilution;hemodynamics;Hemoglobin;Hemorrhage;high risk;Hour;improved;in vivo;Income;indexing;Instruction;Intercellular Fluid;Intervention;Label;Laser Speckle Imaging;Lasers;Light;Logistic Regressions;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Operative Surgical Procedures;optical sensor;Optics;Organ;Outcome;Outcome Measure;Pathway interactions;Patient Recruitments;Patient Schedules;Patients;Perfusion;Peripheral;peripheral blood;Pharmacological Treatment;Physiological;Placenta Accreta;Population;porcine model;Postpartum Hemorrhage;Postpartum Period;Pregnancy;pregnant;prevent;recruit;Resource-limited setting;response;Risk;Saline;Schedule;Sensitivity and Specificity;sensor;Signal Transduction;Spectrum Analysis;System;Techniques;Technology;Testing;Time;tissue oxygenation;tool;Transfusion;Translating;United States;Validation;Visual;Water;wearable device;wearable monitor;wearable sensor technology

PROJECT_TITLE: Wearable multifunctional optical device for early detection of postpartum hemorrhage


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The prevalence of gestational diabetes mellitus (GDM) has increased substantially, and it is associated with both short- and long-term adverse outcomes for both women and their children. The strategies used for GDM rely on diagnosis and treatment in the third trimester, but these have not consistently reduced or eliminated the adverse outcomes that occur. Therefore, there is a vital need to develop novel strategies, including earlier diagnosis and better ascertainment of blood sugar profiles, that predict adverse outcomes related to dysglycemia, which will result in better treatment approaches and outcomes.

PI_NAMEs: LOWE, WILLIAM L;YEE, LYNN M (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Admission activity;advanced analytics;Adverse effects;adverse maternal outcomes;adverse outcome;adverse pregnancy outcome;Birth;Birth trauma;Blood Glucose;Cardiovascular Diseases;Cesarean section;Child;Childhood;Clinical;Clinical Trials;clinically relevant;Continuous Glucose Monitor;Data;Data Analyses;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Dystocia;Early Diagnosis;early pregnancy;Evaluation;Evolution;experience;fasting glucose;First Pregnancy Trimester;Frequencies;Future;Gestational Age;Gestational Diabetes;Glucose;glucose monitor;Health;high risk;Hour;Hyperglycemia;Hypertension;Hypoglycemia;insight;Intervention;Low Birth Weight Infant;maternal hyperglycemia;maternal outcome;Measures;Metabolic;Metabolic Diseases;Natural History;Neonatal;Neonatal Hypoglycemia;Neonatal Intensive Care Units;neonatal outcome;newborn adiposity;Newborn Infant;novel strategies;Obesity;OGTT;Outcome;Outcome Study;Pattern;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;Prevalence;Randomized;Risk;Shoulder;success;Suggestion;therapy design;Third Pregnancy Trimester;Time;Woman;Women's cohort;women's diagnosis

PROJECT_TITLE: Glycemic Profiles and Pregnancy Outcomes Study (GLOSS)


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: MCLENDON, ROGER E (contact)

PROJECT_TERMS: Adult;American Association of Cancer Research;anti-tumor immune response;Award;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker discovery;Biometry;Blood;Blood specimen;blood-brain barrier crossing;Board Certification;Brain Neoplasms;Cells;Certification;CLIA certified;Clinic;Clinical Data;clinical data warehouse;clinical decision-making;Clinical Research;Collaborations;Collection;Consultations;Correlative Study;Data;data integration;data integrity;data management;data platform;Databases;Deoxyguanosine;DNA Damage;DNA sequencing;Drug or chemical Tissue Distribution;early phase clinical trial;Eligibility Determination;Ensure;Evaluation;Excision;experience;Faculty;Freezing;Funding;Gamma-H2AX;gene panel;Genomics;Genotype;Glioblastoma;Goals;good laboratory practice;human tissue;immune cell infiltrate;immunogenic;Immunologic Markers;improved;industry partner;Informatics;innate immune sensing;Institution;Interphase;Investments;Laboratories;Measurement;Measures;Mediating;Methods;Mission;molecular marker;mutational status;neuro-oncology;neuropathology;next generation;novel;novel therapeutics;patient biomarkers;Patients;Pharmacodynamics;Phase 0 Trial;Phenotype;Pilot Projects;Practice Management;preclinical development;predictive marker;primary endpoint;Prognostic Marker;promoter;Protocols documentation;Reporting;Reproducibility;Research;Research Personnel;Research Support;Resected;Resource Sharing;Resources;response;Science;Security;Services;Site;Specimen;Standardization;Stimulator of Interferon Genes;Telomerase;telomere;Testing;testing services;Therapeutic;Therapy Clinical Trials;Tissue Banks;Tissue Procurements;Tissues;Training;transcriptome sequencing;tumor;Tumor Tissue;United States National Institutes of Health;Work

PROJECT_TITLE: Biomarker, Bioinformatics and Biorepository Core


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Patient Safety;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The efficacy of existing therapies for hepatocellular carcinoma (HCC) is highly limited. Therefore, prevention of HCC development in patients at risk, i.e. liver cirrhosis, is urgently needed. Based on prior supportive data generated by us and others, we will evaluate atorvastatin in a placebo-controlled phase II clinical trial for its safety and efficacy in modulating a high-risk HCC gene signature in patients with compensated cirrhosis.

PI_NAMEs: CHUNG, RAYMOND T (contact);HOSHIDA, YUJIN

PROJECT_TERMS: Adult;Adverse event;Affect;arm;atorvastatin;base;Biological Markers;Biopsy;cancer cell;cancer chemoprevention;Cancer Etiology;cancer risk;Cell Proliferation;Cessation of life;Chemoprevention;Chemopreventive Agent;circulating biomarkers;Cirrhosis;Clinical;clinical center;Clinical Chemoprevention;clinical translation;cohort;Companions;Compensation;Complication;Conduct Clinical Trials;Data;design;Development;Disease Progression;Dose;double-blind placebo controlled trial;Drug Kinetics;efficacy testing;efficacy trial;epidemiologic data;Etiology;Fibrosis;follow-up;Future;Gene Expression;genetic signature;hazard;Hepatic;Hepatology;high risk;Human;Immunohistochemistry;improved;in vivo;Incidence;Infrastructure;innovation;International;Intervention;intrahepatic;Invaded;Length;lipophilicity;Liver;liver biopsy;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver inflammation;liver transplantation;Malignant Neoplasms;Measures;Meta-Analysis;Metabolic;Molecular;Monitor;mortality;neoplastic;novel;novel strategies;Observational Study;Oncogenic;Outcome;Participant;Pathway interactions;patient population;Patient Selection;Patients;Pattern;Persons;pharmacodynamic biomarker;Pharmacodynamics;Phase;Phase II Clinical Trials;Placebo Control;Placebos;population based;Positioning Attribute;pre-clinical;Predisposing Factor;prevent;Prevention;prevention clinical trial;Prevention therapy;Prevention trial;Primary carcinoma of the liver cells;primary endpoint;Prognosis;prognostic;Prognostic Marker;prospective;Public Health;Randomized;randomized controlled design;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Reproducibility;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;Risk;risk prediction;Risk Reduction;Safety;Sample Size;screening;secondary endpoint;Serious Adverse Event;Serum;Signal Pathway;Signal Transduction;standard of care;Surrogate Markers;Survival Rate;Testing;Therapeutic;Time;Tissue Sample;Translating;Translational Research;trend;tumor;two-arm study;Viral

PROJECT_TITLE: Trial of Statins for Chemoprevention in Hepatocellular Carcinoma


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Patients with juvenile myelomonocytic leukemia have historically been treated as one uniform disease even though some require little to no treatment while others relapse after stem cell transplantation. This grant will support a clinical trial in which patients with newly diagnosed JMML receive risk stratified therapy based on our two validated biomarkers, mutational burden and DNA methylation status. We will also perform pre-clinical studies aimed at interrogating the JAK/STAT pathway, with the goal of expanding treatment options beyond hematopoietic stem cell transplantation.

PI_NAMEs: STIEGLITZ, ELLIOT  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Algorithms;Azacitidine;Biological Markers;biomarker validation;CBL gene;chemotherapy;Child;Childhood;Clinical;Clinical Trials;clinically actionable;Collaborations;Combination Drug Therapy;combinatorial;Cytarabine;Data;demethylation;Development;Diagnosis;Disease;Disease Progression;Disease remission;Disease-Free Survival;disorder control;DNA;DNA Methylation;early childhood;early phase clinical trial;efficacy testing;Epigenetic Process;epigenomics;Europe;experience;fludarabine;Future;Genes;Genetic;Genetically Engineered Mouse;genome-wide;Genomics;Genotype;Goals;Grant;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;high risk;Hypermethylation;implementation intervention;improved;improved outcome;In complete remission;In Vitro;in vivo evaluation;induced pluripotent stem cell;Inferior;inhibitor;International;Intervention Trial;JAK2 gene;Juvenile Myelomonocytic Leukemia;KRAS2 gene;Lead;MAP Kinase Gene;MEKs;Methylation;Molecular;mouse model;Mutate;Mutation;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;Newly Diagnosed;NF1 gene;Outcome;outcome prediction;Pathway interactions;patient derived xenograft model;patient stratification;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;Phase;pre-clinical;Pre-Clinical Model;preclinical study;primary endpoint;Prognosis;prognostic;PTPN11 gene;Relapse;Resolution;response;Risk;risk stratification;side effect;Signal Transduction;standard of care;Stem cell transplant;Survival Analysis;synergism;targeted treatment;Testing;Therapeutic;therapeutic target;transplantation therapy;Work

PROJECT_TITLE: Implementation of an interventional, risk-adapted clinical trial for children with newly diagnosed juvenile myelomonocytic leukemia.

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PROJECT_TERMS: adaptive immune response;Adult;aggressive therapy;base;Biological Assay;Biological Markers;biomarker identification;blood-brain barrier crossing;blood-brain barrier penetration;cancer cell;Cell Death;Cell division;cell killing;Cell Line;Cells;Cessation of life;Chromosomes;Clinic;Clinical;clinical application;Clinical Trials;Clinical Trials Design;Collaborations;Colon;Colon Carcinoma;Complex;cytokine;cytotoxic;Data;Deoxyguanosine;deoxyguanosine triphosphate;DNA;DNA Damage;Dose;Dose Limiting;efficacy testing;Enrollment;Enzymes;Excision;Flow Cytometry;Functional disorder;Genes;Glioblastoma;Glioma;Goals;Guanine;Human;immune checkpoint blockade;Immunocompetent;immunogenic;Inflammatory;Inflammatory Response;Innate Immune Response;Lung;Lung Carcinoma;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;Melanoma;Modeling;molecular marker;mouse model;Mutation;mutational status;Natural Immunity;Normal Cell;Normal tissue morphology;novel;Operative Surgical Procedures;Organoids;Pathologic;Patients;pharmacodynamic biomarker;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical evaluation;prevent;Prodrugs;promoter;Publishing;purine analog;Radiation;Resources;response biomarker;RNA-Directed DNA Polymerase;Series;Signal Pathway;Slice;small molecule;Specificity;Stimulator of Interferon Genes;targeted treatment;Telomerase;Telomerase inhibition;telomere;Telomere Maintenance;Telomere Shortening;temozolomide;Testing;Therapeutic;therapy resistant;Tissues;Toxic effect;transcriptomics;tumor;Tumor Immunity;tumor microenvironment;United States;Work;Xenograft procedure

PROJECT_TITLE: 6-thio-2'-deoxyguanosine in GBM: Pre-clinical Evaluation of Mechanism of action, Efficacy and Biomarker identification


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Pancreatic cancer is almost universally fatal. Metaplastic tuft cells (MTCs) are hypothesized to be tumor initiating cells in pancreatic cancer. In this proposal, I will use novel genetic models of pancreatic cancer to determine the fate of MTCs and the role of c-Myc in MTC transdifferentiation and metastasis initiation.

PI_NAMEs: SALAS-ESCABILLAS, DANIEL JAMES (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Ablation;Acinar Cell;Alleles;Automobile Driving;Bladder;c-myc Genes;Cancer Etiology;cancer initiation;cancer stem cell;cancer type;Carcinoma;CDKN2A gene;Cell Communication;cell type;Cells;cellular microvillus;Cessation of life;Characteristics;Chromogranin A;chronic pancreatitis;Collaborations;Cues;Data;daughter cell;detection method;Development;Diagnosis;Disease;Down-Regulation;Duct (organ) structure;Early Diagnosis;effective therapy;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;experimental study;Generations;Genetic Models;Homeostasis;Human;Intestines;knock-down;KRAS2 gene;KRASG12D;Label;live cell imaging;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Metaplasia;Methods;Modeling;mouse model;Mus;Mutation;Neoplasm Metastasis;Neoplasms;Neuroendocrine Cell;Neurosecretory Systems;Nose;novel;Oncogenes;Organ;Organoids;overexpression;Pancreas;pancreatic cancer model;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Patients;Population;Population Heterogeneity;progenitor;Property;Publications;recombinase;Reporter;Repression;Rodent;Role;Sensory;stem cell biomarkers;stem cells;Stomach;Surface;Survival Rate;Synaptophysin;System;Testing;Tissues;TP53 gene;transcriptomics;transdifferentiation;tumor initiation;tumor progression;Tumor-Suppressor Gene Inactivation;Up-Regulation;Work

PROJECT_TITLE: Understanding the Fate of Metaplastic Tuft Cells in the Progression of Pancreatic Cancer


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: KHASRAW, MUSTAFA  (contact)

PROJECT_TERMS: Adult;Adult Glioblastoma;Aftercare;Animals;anti-tumor immune response;Biological;Biological Markers;Biology;Blood - brain barrier anatomy;Brain Neoplasms;Cell Death;Cells;checkpoint inhibition;Clinical Trials;cohort;Collaborations;Cyclic GMP;cytotoxicity;Data;Deoxyguanosine;Dependence;design;DNA Damage;early phase clinical trial;efficacy evaluation;Euthanasia;Evaluation;Event;Evolution;experience;experimental study;Failure;Gamma-H2AX;Genes;Glioblastoma;Gliomagenesis;Goals;Harvest;Human;Immune;immune activation;Immune response;Immune signaling;Immunity;immunogenic;Immunosuppression;Immunotherapy;Implant;improved;in vivo;Induced Mutation;Infrastructure;innate immune sensing;Interferons;Malignant Neoplasms;Measures;Mediating;Methods;Modality;Modeling;Molecular;Monitor;Mus;mutant;Mutation;Mutation Detection;neoplasm immunotherapy;Newly Diagnosed;novel;novel therapeutics;Operative Surgical Procedures;patient derived xenograft model;patient population;Patients;Pattern;pharmacodynamic biomarker;Pharmacodynamics;Phase;Phase 0 Clinical Trial;Phase 0 Study;Phase 0 Trial;pre-clinical;Pre-Clinical Model;preclinical development;preclinical study;predictive marker;pressure;primary endpoint;Prodrugs;promoter;purine analog;Radiation;Recurrence;Relapse;Resistance;response;response biomarker;Role;Seminal;Signal Transduction;standard of care;Subgroup;targeted agent;Telomerase;telomere;temozolomide;Testing;Therapeutic;Time;Tissues;Toxic effect;transcriptome sequencing;treatment response;tumor;tumor heterogeneity;Tumor Tissue;Tumor-infiltrating immune cells;Up-Regulation;Work

PROJECT_TITLE: 6-thio-2'-deoxyguanosine in GBM: Evaluation of Pharmaco-dynamics, Effects of Prior Standard of Care and A Human Phase 0 Study


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE We will investigate the therapeutic potential of temozolomide (TMZ) with PCI-24781/abexinostat, a drug candidate identified through connectivity mapping to specifically target the glioblastoma (GBM) signature, using GBM organoid models, genetically engineered GBM mouse models, and GBM patient-derived xenografts. We will also conduct a phase I study of metronomic TMZ with PCI-24781 to identify this combination’s dose-limiting toxicity and therapeutic potential. From our preclinical findings, we anticipate that synergy between PCI-24781 and TMZ will enhance TMZ efficacy and improve patient survival.

PI_NAMEs: BATRA, SURINDER K.;SHONKA, NICOLE  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acetylation;Adjuvant;Adult;Aftercare;Apoptosis;Archives;ATAC-seq;bioinformatics tool;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain Neoplasms;cancer genetics;candidate identification;Cell Line;Cells;CHEK1 gene;chemoradiation;Chromatin;Clinical;Clinical Research;Clinical Trials;cohort;Combined Modality Therapy;Communities;Correlative Study;Data;Data Set;Databases;design;DNA Repair;DNA Repair Pathway;Dose;Dose Limiting;drug candidate;drug repurposing;Drug resistance;effective therapy;efficacy evaluation;Enzymes;epidermal growth factor receptor VIII;Excision;exosome;FDA approved;Gene Expression Profiling;Genetic;Genetic Engineering;genetic signature;Glial Fibrillary Acidic Protein;Glioblastoma;Glioma;HDAC1 gene;HDAC11 gene;HDAC2 gene;Heat-Shock Proteins 90;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;improved;In Vitro;in vivo;inhibitor;Interruption;LoxP-flanked allele;Malignant - descriptor;Malignant neoplasm of brain;Maps;Measures;MGMT gene;Modality;Modeling;mouse model;Mus;neuro-oncology;novel;Operative Surgical Procedures;Organoids;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;phase 1 study;Phase I Clinical Trials;pre-clinical;preclinical study;Protein Acetylation;Proteins;PTEN gene;Radiation therapy;Receptor Protein-Tyrosine Kinases;Recurrence;Resected;Resistance;response;response biomarker;Sampling;Signal Transduction;Specificity;success;Survival Rate;synergism;targeted therapy trials;temozolomide;Testing;Therapeutic;tool;Toxic effect;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Burden;tumor growth;Vorinostat;Xenograft procedure

PROJECT_TITLE: Connectivity mapping identified novel combination therapy for glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Teenage Pregnancy

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: Project Narrative Although teen pregnancy rates have declined in the U.S. over the last several decades, disparities persist: teen birth rates among Latinx teens in the U.S. are 1.5 times higher than the national average and more than 2 times higher in rural areas compared to rural White teens. Best practices for implementing evidence-based unintended teen pregnancy prevention programs in emerging immigrant rural communities remain largely unknown. This study uses questionnaires and interviews with youth and community members, to co-develop and pilot test an unintended teen pregnancy prevention intervention in an emerging immigrant Latinx rural community, aiming to decrease reproductive health disparities in marginalized communities across the country.

PI_NAMEs: BARRAL, ROMINA LORELEY (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 18 year old;Address;Adolescent;Adolescent Medicine;arm;Attention;behavior change;Behavior Therapy;Behavioral Research;Birth Rate;career;career development;Caring;Child;Clinical Research;Clinical Trials;Communities;community center;community engaged research;community engagement process;community partners;condoms;Consensus;contextual factors;cost;Country;County;culturally appropriate intervention;design;Development;Development Plans;Disparity;Disparity population;disparity reduction;economic outcome;Education;Ethnic Origin;evidence base;Evidence based intervention;experience;Explosion;Family;feasibility trial;follow-up;Funding;Geographic Factor;Goals;Health;Health behavior change;health disparity;Hybrids;Immigrant;Immigration;implementation framework;implementation study;improved;Individual;informant;innovation;intersectionality;Intervention;Intervention Trial;Interview;Investigation;K-Series Research Career Programs;Kansas;Knowledge;Latina;Latinx;Latinx population;marginalized community;Measures;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Minority Groups;Mission;Mothers;National Institute on Minority Health and Health Disparities;novel;patient oriented;Patient Self-Report;Physicians;Pilot Projects;pilot test;Population;Positioning Attribute;Pregnancy in Adolescence;pregnancy prevention;Pregnancy Rate;Prevention program;preventive intervention;Process;Public Health;Questionnaires;Race;Reproductive Health;Research;Research Methodology;Rural;rural America;rural area;Rural Community;rurality;Scientist;secondary outcome;Sex Behavior;sexual risk behavior;sexual risk reduction;Sexuality;skills;social norm;Structure;teen birth;Teenagers;Testing;theories;Theory of Change;therapy design;Training;Training Activity;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Reducing reproductive health disparities among Latinx youth living in rural communities

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Common genetic variation is a substantial contributor to autism severity, yet the complicated genetic underpinnings of autism have hampered the discovery of disease modifying genes. Here, I will model a highly penetrant ASD mutation (PTEN) in a library of 200 genetically diverse iPSC lines from ASD and neurotypical individuals to identify regions of the genome which influence autism relevant cellular phenotypes. I will then explore the mechanisms by which genetic variants affect phenotypic outcomes in idiopathic ASD patients, from whom iPSC lines were generated, and in ~600 patients with various PTEN mutations.

PI_NAMEs: WOLTER, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Affect;ASD patient;autism spectrum disorder;Behavioral;Bioinformatics;Brain imaging;brain overgrowth;brain size;California;career;causal variant;Cell Culture Techniques;Cell Line;Censuses;Child;Clinical;Clinical Data;Cognitive deficits;cost effective;Data;Disease;disease model;Disease Outcome;disorder subtype;Environmental Risk Factor;Etiology;Experimental Designs;experimental study;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genomics;Genotype;Goals;Heterogeneity;Human;Human Genome;Image Analysis;imaging study;improved outcome;Individual;Induced Mutation;induced pluripotent stem cell;Infant;Knowledge;Libraries;Macrocephaly;Magnetic Resonance Imaging;Measures;Mentors;Methods;model of autism spectrum disorder;Modeling;Molecular;Mutation;nerve stem cell;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neuropsychiatry;Noise;novel;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;polygenic risk score;Population;post-doctoral training;prevent;Proliferating;rational design;Regenerative Medicine;repository;Research;Resources;response;Risk;Risk Factors;Sample Size;Severities;Severity of illness;sex;Sex Bias;Shapes;Source;stem cell differentiation;stem cell proliferation;System;targeted treatment;Testing;Training;trait;Validation;Variant

PROJECT_TITLE: Discovery of genetic modifiers of PTEN-ASD severity in a library of genetically diverse iPSC lines

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]