NIH_SPENDING_CATS: Digestive Diseases

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Digestive and liver diseases have a significant effect on public health and health care utilization costs. This application requests support for a conference that nurtures junior investigators, with an emphasis on including underrepresented populations, interested in digestive and liver disease research. Our goals are to provide additional mentoring support during a critical time in their career and to familiarize them with the scientific and technological expertise available at Midwest Digestive Disease Research Core Centers.

PI_NAMEs: COMINELLI, FABIO  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academic skills;Address;biological systems;career;career development;Chicago;Clinic;Collaborations;Communication;Communities;cost;design;Digestive System Disorders;Disease;Diverse Workforce;Event;experience;Faculty;faculty research;Feedback;Fertilization;Financial Support;Funding;Goals;Growth;Health;health care service utilization;improved;Institution;interest;Knowledge;Liver diseases;member;Mentors;Mentorship;Midwestern United States;National Institute of Diabetes and Digestive and Kidney Diseases;Patient Care;Pediatric Hospitals;peer influence;Postdoctoral Fellow;Productivity;Program Development;programs;Public Health;Request for Applications;Research;Research Personnel;Research Project Grants;role model;Scientist;Services;Site;Speed;Study Section;symposium;Teacher Professional Development;Technology;Time;Travel;Underrepresented Populations;Universities;Washington;Woman;Work

PROJECT_TITLE: Midwest DDRCC Alliance Conference (Hosted by the Cleveland DDRCC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O3)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Support is requested for travel by academic US scientists to participate in a scientific meeting that brings together researchers exploring common aspects of cell invasion in development, cancer, and organ fibrosis. The field of Epithelial Mesenchymal Transition is rapidly expanding and the conference will bring together groups of developmental biologists, cell biologists, and cancer biologists who do not normally intersect to address cutting- edge research on EMT.

PI_NAMEs: YANG, JING  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Adherence;Adult;Area;Arizona;Asia;Australia;Basement membrane;Biological;Brain;Canada;Cell Physiology;Cells;Cellular biology;clinical translation;Consensus;Cytoskeletal Modeling;Data;Development;Discipline;Elements;Embryo;Epithelial Cells;Epithelium;Europe;Extracellular Matrix;Fibrosis;Funding;gastrulation;Genetic;Genetic Transcription;graduate student;Growth Factor;Heart Valves;International;interstitial;Invaded;Islets of Langerhans;Japan;Journals;Malignant Neoplasms;meetings;Mesenchymal;Molecular;Neoplasm Metastasis;Neural Crest Cell;North America;novel strategies;Organ;Organogenesis;Paris, France;Pathologist;Pathology;Poland;Postdoctoral Fellow;Process;Publishing;Reagent;Research;Research Personnel;Schedule;Science;Scientist;Signal Transduction;Singapore;small molecule inhibitor;Societies;Somites;Spain;Students;symposium;Systems Biology;Techniques;Texas;therapy resistant;three dimensional structure;Tissues;Travel;United States;United States National Institutes of Health;Update;vaccine development;Work;wound healing

PROJECT_TITLE: 2024 Epithelial Mesenchymal Transition (EMT) International Meeting

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research

ORG_CITY: SUNNYSIDE

ORG_NAME: BELLAGE, INC.

ORG_STATE: NY

PHR: ________________________________________________________________________________________ PROJECT NARRATIVE The Adult Wellbeing CheckUp (AWC) platform (funded by the parent award) will facilitate wellbeing assessments, referrals, and recommendations of American adults over 65 years of age to age well. By personalizing to the context of an individual’s life and utilizing evidence-based behavior change principles, the platform will encourage older adults to take actions to improve their individual and overall wellbeing domains. The AWC commercialization plan relies on the reporting of the AWC to be delivered such that its initial customers will pay for ongoing annual subscriptions to the service. In this supplement, we intend to expand the AWC prototype with additional reporting features and a consumer-friendly, searchable data repository. These features, which were not previously proposed, will allow senior centers (and additional customer segments) to more deeply understand the engagement as well as health of their members. By adding these features, we can also better support and enable the AWC commercialization plan.

PI_NAMEs: FIRMAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adult;Age;Age Years;American;behavior change;checkup examination;commercialization;data repository;evidence base;evidence based guidelines;Friends;Funding;Health;human old age (65+);improved;Individual;innovation;Life;member;older adult;parent grant;parent project;Personal Satisfaction;prototype;Recommendation;Reporting;Services;web services

PROJECT_TITLE: Expanding the AWC Prototype with Additional Reporting and Analytics Features (Supplement to R44AG082602, Adult Wellbeing Checkup (AWC))


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: We present a graded approach – beginning with imaging and ending with therapy – to management of advanced, aggressive prostate cancer (PC) by leveraging what we have learned over the past two decades about the prostate-specific membrane antigen (PSMA). We propose machine learning methodology to enhance clinical interpretation of PSMA PET scans for patient management, and development of sensitive, new detection methods using photoacoustic imaging ultimately to avoid unnecessary surgery. We also propose ways to improve immunotherapy for the lethal neuroendocrine subtype of PC and to re-program it to render it more susceptible to emerging PC therapies.

PI_NAMEs: POMPER, MARTIN G (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Active Sites;Address;Adenocarcinoma;Affinity;Androgens;Anti-androgen Therapy;Antigen Targeting;Attention;Biological;cancer biomarkers;cancer cell;CAR T cell therapy;Categories;CEACAM5 gene;Cell membrane;chimeric antigen receptor T cells;Clinical;Clinical Data;Clinical Management;Data;Data Set;design;Detection;detection method;Development;Discipline of Nuclear Medicine;Disease;Engineering;FOLH1 gene;Funding;Genes;Goals;Human;Image;Image Enhancement;imaging agent;imaging study;Immunotherapy;improved;in vivo;Indolent;Interleukin-12;Laboratories;Learning;Lesion;Machine Learning;machine learning method;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Methods;Modernization;molecular imaging;Monitor;Morbidity - disease rate;multimodal data;Nanotechnology;Neoplasm Metastasis;Neuroendocrine Prostate Cancer;Neurosecretory Systems;Normal tissue morphology;optical sensor;Output;Patients;Pharmaceutical Preparations;photoacoustic imaging;Positioning Attribute;Positron-Emission Tomography;Predisposition;prevent;Productivity;prognostic significance;programs;Proliferating;promoter;Prostate;Prostate Cancer therapy;Radiation therapy;Reagent;Recycling;Reporter Genes;scaffold;Scientist;Signal Transduction;small molecule;Solid Neoplasm;spatial relationship;Specificity;Specimen;synthetic antibodies;System;T-Lymphocyte;targeted agent;targeted imaging;Targeted Radiotherapy;Techniques;Technology;Testing;theranostics;Therapeutic Studies;Tissues;Training;Translations;tumor;tumor microenvironment;Unnecessary Surgery;Urea;Work;X-Ray Computed Tomography

PROJECT_TITLE: Enhanced imaging and treatment of aggressive subtypes of prostate cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Patients who have cancer that has spread to distant sites in the body have a poor prognosis. Macrophages are a type of cell that surrounds the cancer and supports its growth. We will understand how these macrophages enable cancers to grow in other organs in the body and test treatments against them.

PI_NAMEs: HAYDEN GEPHART, MELANIE  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anti-Inflammatory Agents;Architecture;Astrocytes;Automobile Driving;Behavior;Biological Models;Blood - brain barrier anatomy;Brain;Cause of Death;cell motility;cell type;Cells;checkpoint therapy;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Colon Carcinoma;Colorectal Cancer;colorectal cancer metastasis;Development;Distant;Distant Metastasis;Endothelial Cells;Exhibits;Extracellular Matrix;Fibroblasts;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Markers;Growth;Human;Imaging Techniques;Immune;Immunofluorescence Immunologic;in vivo;innovation;insight;interest;Invaded;Knock-out;Knowledge;Ligands;Liver;Macrophage;Malignant Neoplasms;Mediating;Mediation;metastatic colorectal;Metastatic malignant neoplasm to brain;metastatic process;Microfluidic Microchips;Microfluidics;Microscopy;migration;Modeling;Molecular;monocyte;Movement;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Organ;osteopontin;Pathway interactions;Patients;Pattern;Pericytes;Phenotype;physiologic model;Physiological;Pirfenidone;Play;prevent;Process;Prognosis;programs;receptor;Research;Resources;response;Role;Site;small molecule;small molecule inhibitor;synergism;System;Systems Biology;T cell infiltration;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;tumor behavior;Tumor Cell Invasion;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumorigenic

PROJECT_TITLE: Delineating the role of SPP1+ macrophages in colorectal cancer metastasis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The purpose of this conference is to convene nurse researchers who work in clinical practice settings to discuss the challenges and opportunities presented by their work. The long-term goal of the conference is to accelerate the scale, scope, speed, and rigor of research led by nurses in the clinical practice setting so that their work can have a greater impact on the quality, safety, accessibility, affordability, and equity of healthcare in the United States. The outcome of the conference will be a five-year strategic framework outlining the mission, vision, goals, strategic priorities, and cross-cutting strategies for clinically based nurse researchers to achieve this goal.

PI_NAMEs: COHEN, BEVIN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Setting a Strategic Framework to Maximize the Impact of Clinically Based Nurse Researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-T (01)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative This project will explore the role of the hippocampal memory system in the incubation of craving for rewarding items by combining neuroimaging methods and natural language processing techniques. The F99 phase will identify the neural regions involved in instrumental markers of craving and relate them to linguistic profiles of subjective expressions of craving. The K00 phase will expand this program of research into clinically-relevant populations (e.g., nicotine users) to examine these same associations in a substance use population to enhance our understanding of substance-related alterations in reward memories related to drug craving.

PI_NAMEs: RUIZ, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Abstinence;addiction;Address;Affective;Anatomy;Animal Behavior;Animal Model;Animals;Applications Grants;Automobile Driving;Behavior;Behavioral;Biological Assay;Clinical;clinically relevant;Cognitive;cognitive neuroscience;Complex;Computer Analysis;Consumption;Corpus striatum structure;craving;Cues;Data;Dedications;Development;Dimensions;drug craving;drug reward;Drug usage;effective therapy;Elements;Emotional;Event;experience;Exposure to;Feeling;Fellowship;Food;food craving;Functional Magnetic Resonance Imaging;Goals;graduate school;Hippocampus;Human;human model;Incubated;Individual;Intervention;Learning;Length;Linguistics;Measures;Medial;Memory;Methods;Modeling;Natural Language Processing;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;Nicotine Use Disorder;nicotine user;non-drug;novel;Nucleus Accumbens;Patient Self-Report;Pharmaceutical Preparations;Phase;Play;Population;Postdoctoral Fellow;pre-doctoral;Prefrontal Cortex;Process;programs;Recording of previous events;Relapse;Research;Research Project Grants;response;reward processing;Rewards;Rodent Model;Role;Sampling;Self Assessment;substance use;Substance Use Disorder;System;Techniques;theories;Time;Tobacco Use Disorder;tool;Work

PROJECT_TITLE: Neural and Behavioral Representations of a Transdisciplinary Model of Craving in Normative and Substance Use Populations

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Infectious Diseases;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Patients undergoing hematopoietic cell transplantation (HCT) experience a period of bone marrow failure, which often requires significant transfusion support to replace low numbers of red blood cells, platelets and/or granulocytes. Together, the 3 independently meritorious projects proposed here, facilitated by the two cores, will yield a unified, focused, productive program that meaningfully elucidates the molecular and cellular mechanisms underlying the effect and effectiveness of blood transfusion in the peri-transplant setting with the ultimate goal of developing more efficient and effective Transfusion Medicine related strategies for the benefit of the blood transfusion recipients.

PI_NAMEs: LUO, HONGBO R (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adopted;Affect;allotransplant;Area;Autologous Transplantation;Bacterial Infections;Biology;Blood Cells;Blood Platelets;blood product;Blood Transfusion;Blood Vessels;Bone Marrow;Bone Marrow Diseases;Bone marrow failure;Bone Marrow Transplantation;Cell Death Signaling Process;Cell Therapy;Cells;Cessation of life;Clinical;clinical efficacy;Collaborations;cost effectiveness;Cryopreservation;Cytometry;Defect;design;Effectiveness;empowerment;Endocytosis;Engraftment;Ensure;Erythrocyte Transfusion;Erythrocytes;experience;experimental study;Functional disorder;Gene Modified;Glues;Goals;granulocyte;Half-Life;Hematological Disease;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hemorrhage;Image;improved;individualized medicine;Infection;innovation;insight;Intervention;Investigation;Knowledge;Lead;Lesion;Medical;Membrane;Metabolic;Modernization;Molecular;multidisciplinary;Mycoses;Neutropenia;neutrophil;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;pharmacologic;Platelet Transfusion;prevent;Procedures;Process;Productivity;Program Research Project Grants;programs;Public Health;Reagent;Recording of previous events;Regimen;Regulation;Research;Research Project Grants;response;RHOA gene;Role;Sickle Cell Anemia;Signal Transduction;Specialist;Sum;Supporting Cell;synergism;Thrombocytopenia;trafficking;Transfusion;transfusion medicine;Transplant Recipients;Transplantation;United States National Institutes of Health;Vesicle;virtual

PROJECT_TITLE: Novel Strategies to Improve Blood Transfusion Practice

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it seeks to develop personalized anti-tumor vaccines, focusing here on the childhood malignancy neuroblastoma. The research is highly relevant to the NIH mission and the urgent unmet need of developing rational evidence-based therapeutic and relapse preventative strategies to reduce the health burden of cancer. This integrated multiple principal investigator project is designed to catalyze improved cure rates with decreased morbidity for patients with high-risk neuroblastoma, and many advances will be applicable to the field of cancer in general.

PI_NAMEs: MARIS, JOHN M (contact);SCHOENBERGER, STEPHEN PHILIP

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Cancer Burden;Childhood;clinical translation;Combined Modality Therapy;design;Development;Disease remission;Engineering;evidence base;Genetically Engineered Mouse;Goals;Health;high risk;Immunotherapy;improved;improved outcome;Incidence;innovation;interest;lipid nanoparticle;Malignant Childhood Neoplasm;Malignant Neoplasms;Messenger RNA;Mission;Morbidity - disease rate;Motivation;mouse model;Mutation;neoantigen vaccination;neoantigen vaccine;neoantigens;Neuroblastoma;novel therapeutic intervention;Nucleosides;parent project;Parents;Patient-Focused Outcomes;Patients;Pennsylvania;Peptide Vaccines;Peptides;personalized cancer vaccines;Prevention strategy;Principal Investigator;Public Health;Relapse;relapse prevention;Research;Residual Neoplasm;response;RNA;Sympathetic Nervous System;Testing;Therapeutic;Toxic effect;tumor;United States National Institutes of Health;Universities;vaccination strategy;Vaccines

PROJECT_TITLE: Personalized neoantigen vaccines using nucleoside-modified mRNA-lipid nanoparticles


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cancers cannot initiate or progress if their subcellular components are unable to overcome the stresses that accompany uncontrolled proliferation and growth. This Center seeks a predictive understanding of subcellular adaptations that must take place to accommodate and subvert the stresses that naturally occur in response to cancer-causing genetic alterations. Successful models of such adaptations will lead to secondary inferences about where cancer cells become vulnerable as a result of their internal adaptations.

PI_NAMEs: JANES, KEVIN A (contact);LAZZARA, MATTHEW J

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adopted;Aneuploidy;Automobile Driving;Cancer Biology;cancer cell;Cancer Model;cancer type;carcinogenesis;career;Cell Culture Techniques;Cell Death;Cell membrane;cell type;Cells;Cellular biology;Charge;Chromosomes;Chronic;Clinical and Translational Science Awards;clinical practice;Collaborations;Colorectal Cancer;Complex;cost;Couples;Cultured Cells;Cytoskeleton;Data;Decision Making;Dedications;Defect;Disease;Ecosystem;Education;Elements;Epidermal Growth Factor Receptor;Eukaryota;experimental study;Faculty;feature detection;feature extraction;Fostering;Genetically Engineered Mouse;Genomics;Glioblastoma;Goals;Growth;Image;image registration;Immunofluorescence Immunologic;Indirect Immunofluorescence;innovation;Institution;interoperability;Joints;KRAS2 gene;Lead;Leadership;learning strategy;Length;Lesion;Life;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mentorship;Metabolic;Metaphase;Metastatic Neoplasm to the Liver;Mitochondria;mitochondrial membrane;Mitotic;Modeling;multidisciplinary;mutant;Mutation;NCI Center for Cancer Research;Neoplasm Metastasis;Oncogene Activation;Oncogenes;Oncogenic;Organelles;outreach;Pathway interactions;Phase;Phenotype;Pilot Projects;Play;Positioning Attribute;Primary Neoplasm;Process;programs;Proliferating;Records;Recurrence;repaired;Research;Research Personnel;Research Project Grants;residence;Resolution;Resource Sharing;Resources;response;Rest;Role;Secondary to;Signal Transduction;Site Visit;Standardization;Stress;Structure;success;summer research;System;Systems Analysis;Systems Biology;Testing;Training;transcription factor;tumor;tumorigenesis;undergraduate research experience;Universities;Virginia;Vision

PROJECT_TITLE: Cytoskeletal dynamics during uncontrolled macropinocytosis-induced cancer cell death


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The Gordon Research Conference (GRC) on “Alcohol-Induced End Organ Diseases” will create a state-of-the- art forum for discussion of alcohol research, including studies of acute and chronic alcohol exposure across the entire spectrum of lifespan on the significant and widespread detrimental organ system effects of alcohol. The conference will provide a unique forum to bring together a diverse range of young and established alcohol researchers, and experts in complementary fields, to discuss groundbreaking advances in how alcohol consumption results in tissue injury. The meeting format employed by the GRC facilitates open discussions, builds bridges in between investigators in different disciplines, as well as between preclinical and clinical investigators and fosters the development of the next generation of alcohol researchers.

PI_NAMEs: LIANGPUNSAKUL, SUTHAT ;SMATHERS MCCULLOUGH, REBECCA LEANNE (contact)

PROGRAM_OFFICER_NAME: JUNG, KATHY

PROJECT_TERMS: Acceleration;Acute;Address;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Area;Arrhythmia;Body System;Breast;career;Chronic;Clinical Investigator;Collaborations;Colon;Communities;Dementia;Development;Diabetes Mellitus;Diagnosis;disadvantaged background;Discipline;Discrimination;Disease;Disease Progression;Drug abuse;Economic Burden;Economics;Educational workshop;Ensure;Environment;Epidemic;Equity;Etiology;Exposure to;Fetal Alcohol Syndrome;Formulation;Fostering;Future;Future Generations;Generations;Goals;harassment;Health;healthcare burden;Height;Hypertension;Immunologics;improved;Individual;Injury;innovation;insight;International;Knowledge;life span;Liver;Malignant Neoplasms;meetings;Mentorship;Metabolic syndrome;Methodology;minority scientist;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial Ischemia;National Institute on Alcohol Abuse and Alcoholism;next generation;novel strategies;novel therapeutic intervention;Obesity;Organ;organ injury;Osteoporosis;Outcome;Pancreatitis;Pathway interactions;peer;Play;Pneumonia;Postdoctoral Fellow;posters;pre-clinical;Prevalence;prevent;Prevention;repaired;Research;research and development;Research Personnel;Risk;Role;Scientific Advances and Accomplishments;Scientist;Shapes;Societies;Stroke;Structure;student participation;symposium;synergism;Techniques;therapeutically effective;Time;tissue injury;Tissues;Toxic effect;Underrepresented Minority;Underrepresented Populations;unpublished works;Upper respiratory tract;Work

PROJECT_TITLE: Alcohol-Induced End Organ Diseases Meetings

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE This project will investigate the neural and behavioral mechanisms of social visual attention using dynamic and context-rich stimuli. The F99 phase will investigate how and where humans make eye movements toward relevant information during dynamic emotion perception and with the use of computer vision models. The K00 phase extends this research by investigating the neural mechanisms of social visual attention using dynamic and context-rich stimuli as well as naturalistic imaging approaches.

PI_NAMEs: ORTEGA, JEFFERSON  (contact)

PROJECT_TERMS: Adult;analytical method;Area;Attention;Attention deficit hyperactivity disorder;Attentional deficit;attentional modulation;autism spectrum disorder;Behavioral Mechanisms;Brain;Clip;Code;Cognition Disorders;Cognitive;cognitive task;Complex;Computational Technique;Computer Vision Systems;Computing Methodologies;Cues;Data;Decision Making;Detection;directed attention;Disease;Emotional;Emotions;Empathy;Environment;Event;experience;Experimental Designs;Eye;Eye Movements;Face;Facial Expression;Fellowship;Functional Magnetic Resonance Imaging;Future;gaze;Grant;Home;Human;Image;imaging approach;Impairment;improved;Individual;Individual Differences;individuals with autism spectrum disorder;information classification;information processing;insight;Instruction;Intervention;Judgment;Laboratories;Literature;Measures;Mental Depression;Mentorship;Methods;Modeling;movie;neural;neuromechanism;Neurosciences;novel;Participant;Pattern;Perception;Persons;Phase;Postdoctoral Fellow;Process;Research;Research Personnel;Research Project Grants;Scanning;Schizophrenia;Scientist;social;social cognition;social deficits;Social Environment;social neuroscience;Stimulus;Time;Training;trustworthiness;Visual;Visual attention;visual tracking;Vulnerable Populations;Work

PROJECT_TITLE: Investigating Visual Attention Mechanisms During Emotional Inferences


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The research proposed under this F99/K00 fellowship will assess the role of KCC2-mediated synaptic plasticity in the VTA during naturalistic reward learning and resulting network-level modifications in this process. This will establish KCC2 modulation as a novel form of synaptic plasticity during reward learning and will demonstrate the potential of KCC2 as a target for intervention to treat neuropsychiatric disorders that are characterized by aberrant reward learning such as obsessive compulsive disorder and schizophrenia, among many others.

PI_NAMEs: WOO, JOYCE  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Anions;antagonist;Appearance;aspirate;Association Learning;Aversive Stimulus;Behavior;Behavior Control;Behavioral;Brain;Butyric Acids;Cannulas;career;career development;Chloride Ion;chloride-cotransporter potassium;Chlorides;Committee Members;Coupled;Cues;Data;Desire for food;Doctor of Philosophy;dopaminergic neuron;Down-Regulation;drug of abuse;Educational process of instructing;Electrophysiology (science);Ensure;Environment;environmental enrichment for laboratory animals;Event;Exhibits;experience;experimental study;Exposure to;Fellowship;Funding;Genetic;genetic approach;Goals;Homeostasis;Impairment;Implant;in vivo;Infusion procedures;interest;Intervention;Lead;Learning;Link;Mediating;Mediator;Mental Depression;Mentors;Mentorship;Modification;Molecular;Nature;neural;neural network;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;Obsessive-Compulsive Disorder;optogenetics;Organism;Outcome;Output;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physiology;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Predisposition;prevent;Process;programs;Rattus;receptor;receptor function;Regulation;Research;Research Personnel;Research Project Grants;resilience;Resources;response;Rewards;Role;Schizophrenia;Scientist;Shapes;Signal Transduction;Silicon;Slice;Source;Stimulus;Stress;symposium;Synaptic plasticity;therapeutic target;Time;timeline;Training;Translating;transmission process;Universities;Ventral Tegmental Area;Work

PROJECT_TITLE: Time-dependent changes in chloride homeostasis are a mechanism of plasticity critical for learning


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cells can sense and move along shallow gradients of chemoattractants, a process that is essential for normal physiology in the embryo and adult as well as for the pathology of numerous diseases. These studies focus on the molecular mechanisms of motility and directed migration in normal and cancer cells. A thorough understanding of these processes will make it possible to interfere with them specifically in target cells and eventually lead to new therapeutic strategies for cancer and a host of other diseases.

PI_NAMEs: DEVREOTES, PETER N (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acute;Address;Adult;Back;Biological;Biological Assay;cancer cell;cell behavior;Cell Death Induction;Cell Line;cell motility;cell transformation;Cells;Charge;Chemotactic Factors;computer studies;Coupled;Cytoskeleton;design;Dictyostelium;Disease;Embryo;Epithelial Cells;Face;genetically modified cells;Grant;Health;Image;inhibitor;Lipids;Location;Macrophage;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;Methods;migration;Modeling;Molecular;Monitor;Motility;neutrophil;Normal Cell;novel;novel therapeutic intervention;optogenetics;Organoids;Pathology;Pattern;Phagosomes;Phosphotransferases;Physiology;Process;Property;Protein Geranylgeranylation;Proteins;response;screening;Series;Signal Transduction;spatiotemporal;Starvation;Surface;System;tool;Vesicle

PROJECT_TITLE: Excitable Networks in Directed Cell Migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_STATE: OH

PHR: Project Narrative Intra-body Wireless Sensor Link – Large Animal Test The aim of this supplement is to test a COSMIIC System module that can wirelessly connect with wireless sensors indwelling in the body, such as a bladder pressure sensor, in a large animal model.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Abdomen;Acute;Agreement;Algorithms;Animal Experimentation;Animal Model;Animal Testing;Animals;arm;Awareness;base;Bite;Bladder;Catheters;cohort;Communication;Coupled;Custom;Data;data communication;design;Development;Devices;Encapsulated;experimental study;External Infusion Pumps;Feedback;Future;hip bone;Human;Implant;In Vitro;in vitro testing;in vivo;Institution;Intestines;Intrabody;Link;Measurement;Measures;Miniature Swine;Nerve;neuroregulation;Organ;Perforation;Performance;Physiological;power analysis;pressure;pressure sensor;Process;Protocols documentation;remote sensor;Research;sensor;Series;Signal Transduction;Silicones;software development;Specific qualifier value;Spinal Cord;subcutaneous;System;Testing;Time;Translations;transmission process;urinary bladder neck;Urodynamics;Validation;Visualization;wireless;wireless electronic;wireless sensor;Work;X-Ray Medical Imaging

PROJECT_TITLE: Intra-body Wireless Sensor Link - Large Animal Test


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Substantial evidence supports the use of medications to mitigate the harms associated with OUD, but 80% of people with OUD receive no treatment and only a third of those who do access treatment receive evidence- based medications. The present study proposes to develop and test a telehealth intervention for OUD treatment delivery specifically designed for marginalized patients who are likely to struggle with in-person treatment models, which has the potential to impact public health by increasing access to medications for OUD. The mentorship, training, and research activities in this application will prepare the candidate for an independent scientific career conducting intervention research to improve access to substance use disorder treatment and harm reduction services via innovative, low-barrier delivery models.

PI_NAMEs: ARONOWITZ, SHOSHANA V. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Black race;Buprenorphine;career;career development;Caring;Cities;Communities;community engaged research;community setting;COVID-19 pandemic;Data;Dedications;design;Development Plans;Drug user;effective intervention;Equity;Ethics;evidence base;experience;Goals;Grant;Harm Reduction;Health Services Accessibility;Health Services Research;human centered design;implementation barriers;Improve Access;Individual;innovation;Intervention;intervention mapping;Intervention Studies;Latino;Lead;Learning;marginalization;marginalized population;medication for opioid use disorder;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;Morbidity - disease rate;mortality;National Institute of Drug Abuse;opioid use disorder;Patients;Persons;Pharmaceutical Preparations;Philadelphia;pilot trial;Policies;Prevention;Provider;Public Health;Reduce health disparities;Research;Research Activity;research and development;Research Personnel;Scientist;Service delivery model;Services;skills;substance use;Substance Use Disorder;Technology;telehealth;telehealthcare;Testing;therapy development;Training;Training Activity;United States;Writing

PROJECT_TITLE: Improving access to opioid use disorder treatment among marginalized patients with a tailored telehealth intervention


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Musculoskeletal (MSK) conditions are the leading contributor to disability worldwide, between one and three, and one and five people live with a musculoskeletal pain condition. Regular assessment of the state of MSK connective tissue is needed to better identify the pathophysiological origin of the inflammatory and fibrotic response. This research will advance the adaptation of low field magnetic resonance imaging (MRI) as a novel, noninvasive, and affordable point of care diagnostic imaging method capable of assessing the state of MSK connective tissue and effective of regenerative medicine.

PI_NAMEs: WITHERSPOON, VELENCIA  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;Architecture;articular cartilage;Attenuated;Biological;Biological Markers;biomacromolecule;biomarker identification;Biomimetics;Cartilage;Cattle;Characteristics;Charge;Clinical;Collagen;Collagen Fibril;Connective Tissue;Connective Tissue Diseases;crosslink;Degenerative polyarthritis;density;Detection;Development;Diagnostic Imaging;Diagnostic Procedure;Dimensions;disability;Disease;Elastin;Extracellular Matrix;fabrication;Fascia;Fibrillar Collagen;Fibrosis;Fingerprint;Gel;Glycosaminoglycans;Goals;Hyaluronic Acid;Image;imaging modality;Individual;Inflammatory;Inflammatory Response;instrumentation;macromolecule;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maps;materials science;mechanical properties;Mechanical Stress;Mechanics;Methodology;Methods;Mobility decline;Molecular;Musculoskeletal;Musculoskeletal Pain;noninvasive diagnosis;novel;Nuclear;Pathology;Performance;Persons;Physiological;point-of-care diagnostics;Polymers;Porosity;Property;Proteoglycan;Protons;Rattus;Regenerative Medicine;Relaxation;Research;Research Project Grants;Resolution;response;Science;Side;Signal Transduction;Solid;Structure;System;targeted biomarker;tau Proteins;Techniques;Technology;Testing;tissue phantom;Tissues;Translating;Water;Weight-Bearing state

PROJECT_TITLE: Quantitative Characterization of the Extra Cellular Matrix Components of Connective Tissue: Fingerprinting Macromolecular Components through Low-Field Magnetic Resonance

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATHENS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative We propose to build resources to support cancer immunotherapy, by establishing essential software tools and generating data critically missing at present for canine histocompatibility complex class I (MHC-I) genotyping and tumor-specific neoantigen (TSNA) discovery. Our proposed research will significantly enhance the applicability of the dog model for translational research.

PI_NAMEs: HILDEBRAND, WILLIAM ;ZHAO, SHAYING  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Acceleration;Agreement;Alleles;Antibodies;Antigens;Artificial Intelligence;Binding;Biomedical Research;Breeding;cancer immunotherapy;canine model;Canis familiaris;Cells;Collaborations;Complex;cost;Data;Data Analyses;data exchange;Data Set;Genotype;Goals;Human;human data;innovation;interest;large language model;Llama;Major Histocompatibility Complex;Mass Spectrum Analysis;model building;Modeling;neoantigens;open source;Parents;Peptides;protein aminoacid sequence;Protocols documentation;Reagent;Research;Resources;response;sample collection;Sampling;Scientist;Software Tools;Specificity;Statistical Models;Time;tissue culture;Tissue Sample;Training;Translational Research;tumor;Tumor Tissue

PROJECT_TITLE: AI Transfer of the MHC-I Immunopeptidome from Human to Dog

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: NARRATIVE Adenomas are early lesions of colorectal cancer, but only a subset of adenomas progress and become cancer. In light of the well characterized clinical natural history of adenomas, we plan to study them as early lesions and to determine the mechanisms involved in the formation and progression of early precancerous lesions. We hypothesize that adenoma progression requires a suite of hallmark behaviors and that these behaviors are induced by adenoma autonomous factors (e.g. cancer driver gene mutations) and adenoma nonautonomous factors from the “primed colon” or adenoma microenvironment. Our proposed studies will integrate basic and translational cancer research projects to iteratively examine the direct causal relationships and interactions of adenomas, the colon “primed” microenvironment, and host-systemic factors as “co-organizers” of adenoma initiation and/or progression.

PI_NAMEs: DEY, NEELENDU ;GRADY, WILLIAM MALLORY (contact);HALBERG, RICHARD BROTT

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Atlases;Basic Cancer Research;Behavior;Biological Markers;Biology;Cancer Etiology;cancer genetics;Cancer Research Project;cancer type;Cells;Cessation of life;Clinic;Clinical;clinical application;cohort;Collaborations;Colon;colon cancer patients;Colonic Adenoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Data Set;deep sequencing;DNA Sequence Alteration;dysbiosis;Epigenetic Process;Epithelial Cells;experience;Fibroblasts;Gene Mutation;Goals;gut microbiome;Human;human disease;Immune;Individual;Indolent;innovation;Lesion;Light;Malignant Neoplasms;methylation pattern;methylome;microbiome;Mission;Molecular;mouse model;Multiomic Data;mutant;Mutation;Natural History;novel;Pathogenesis;Patients;Persons;Positioning Attribute;premalignant;Recording of previous events;Research Personnel;risk prediction;Science;senescence;Sessile Lesion;Technology;Testing;Tissues;translational cancer research;Translational Research;Translations;Tumor Promotion

PROJECT_TITLE: Spatially Informed Malignancy Signatures for Colon Adenomas


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: NARRATIVE This application seeks funding to support the new career-development pre-meeting, Ignite-Forum, family- and diversity-awards and participation of junior investigators at the 2024 FASEB science research conference on “Transcription, Chromatin, & Epigenetics in Aging”, held in Melbourne, Florida on September 22th – 26th, 2024. The main objective of this meeting is to promote interdisciplinary discussion and collaboration among junior and senior investigators in fields of chromatin, transcription and epigenetics in the context of aging and age-related diseases. This meeting is unique in providing a trainees-focused and highly-interdisciplinary approach towards the establishment of world-wide collaborations between leading scientists interested in the investigation of epigenetics mechanisms in aging and the development of new modalities to target age-related diseases.

PI_NAMEs: DAVID-SHTERNBERG, YAEL E (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Address;age effect;age-related disease;Aging;aging clocks;aging mechanism;aging related;aging related disease;Area;Award;Biological Models;Biology;career;career development;Cell Aging;Cell Physiology;Cells;Chemicals;Chromatin;chromatin modification;Chromatin Structure;Collaborations;Creativeness;Dedications;Development;Discipline;Disease;DNA;Educational workshop;epigenetic aging;epigenetic clock;Epigenetic Process;epigenetic regulation;epigenomics;Event;Explosion;Family;Florida;Fostering;frontier;Funding;Future;Gender;Genetic Transcription;Goals;grasp;Health;Histones;Human;improved;innovation;innovative technologies;insight;interdisciplinary approach;interdisciplinary collaboration;interest;International;Investigation;Knowledge;Learning;Link;meetings;Metabolic;Metabolism;Methodology;Modality;model organism;Molecular;next generation;novel;novel therapeutic intervention;Play;Post-Translational Protein Processing;posters;programs;Proteins;regenerative cell;Regulation;Rejuvenation;Research;Research Personnel;Resolution;RNA;Role;Science;Scientist;single cell technology;symposium;targeted treatment;Technology;Therapeutic;Time;tool;Transcriptional Regulation;Translating;Underrepresented Populations;Work

PROJECT_TITLE: Transcription, Chromatin, and Epigenetics in Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: JOHNSON CITY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  The goal of this research is relevant to the NIH mission because this project is focused on understanding the mechanism of macrophage accumulation during inflammation, which is critical for the curing of many devastating diseases. The proposed research will reveal a potential link between a cholinergic signaling pathway and macrophage migration during inflammation. This information may lead to the design of new drugs for the treatment of different inflammatory diseases.

PI_NAMEs: YAKUBENKO, VALENTIN P (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: adhesion receptor;Adhesions;Adhesives;Affect;alpha-bungarotoxin receptor;Anti-Inflammatory Agents;Arthritis;Atherosclerosis;Autonomic nervous system;Cells;chemokine receptor;cholinergic;Cholinergic Receptors;clinical application;cytokine;Data;design;Development;Diabetes Mellitus;Disease;Endotoxemia;Goals;In Vitro;in vitro Assay;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;interest;Interleukin-6;Investigation;Leukocytes;Link;Macrophage;Mediating;migration;Migration Assay;Mission;Modeling;monocyte;Motility;Neuroimmune;Nicotinic Agonists;novel therapeutics;Organism;Prevention;protective pathway;receptor;Regulation;Research;Role;Signal Pathway;Site;Synapses;Testing;Therapeutic;TNF gene;United States National Institutes of Health;Vagus nerve structure

PROJECT_TITLE: The Role of Neuro-Immune Synapse in Macrophage Migration


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The mammalian brain is energetically demanding with a unique lipid profile, and fatty acid dysregulation in the brain is associated with neurologic disorders including depression and autism spectrum disorders. Specific aspects of fatty acid metabolism such as bioenergetics and lipid homeostasis that may render the brain vulnerable to disease when perturbed are unknown, and studying brain bioenergetic capacity for beta-oxidation and transcriptional responses to lipid availability is fundamental to understanding how brain metabolism impacts nervous system structure, function, cognition, and predisposition to neuropathology. Understanding the metabolic contexts that predispose the brain to duress and impairment may direct future neurological interventions.

PI_NAMEs: WHITE, CORY JUSTIN (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: acylcarnitine;Address;Adipose tissue;Affinity Chromatography;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;autism spectrum disorder;Autopsy;Award;Biochemistry and Cellular Biology;Bioenergetics;Biological Assay;Bipolar Disorder;Brain;brain metabolism;Carbohydrates;career;Carnitine Palmitoyltransferase I;Central Nervous System;Cognition;Communicable Diseases;conditional knockout;Cues;Defect;Dementia;Dependovirus;Development;Diet;dietary;Disease;Doctor of Philosophy;Drug usage;Energy-Generating Resources;Enzymes;Epilepsy;experimental study;Fasting;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fellowship;Funding;Future;Genes;Genetic;Genetic Transcription;Glucose;Goals;Hepatic;HIV;HIV Infections;HIV-associated neurocognitive disorder;Homeostasis;Human;Impaired cognition;Impairment;in vivo;Incidence;indexing;Infection;innovation;interest;Intervention;ketogentic;Ketone Bodies;Ketones;Knock-out;Knockout Mice;Knowledge;Laboratories;Link;lipid metabolism;Lipids;Liver;long chain fatty acid;Mammals;Manuscripts;mass spectrometric imaging;medical schools;Membrane;Mental Depression;Mentors;Metabolic;metabolic profile;Metabolism;metabolome;metabolomics;Molecular Biology;Mood Disorders;mouse model;Mus;National Research Service Awards;Nervous System;Nervous System Disorder;Nervous System Physiology;neuroAIDS;Neurologic;neuropathology;Neurosciences;overexpression;oxidation;Patients;Peripheral;Persons;Phase;Phosphatidylethanolamine;phosphoethanolamine;Phospholipids;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Predisposition;Preparation;programs;Radiolabeled;Regulation;Research;Research Personnel;response;Ribosomes;RiboTag;Role;Schizophrenia;Series;side effect;skill acquisition;skills;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Starvation;Structure;Therapeutic;Tissues;tool;Training;training opportunity;Translating;Work

PROJECT_TITLE: Evaluating Changes to the Metabolic Profile of the Central Nervous System due to Active NeuroHIV Infection


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative  Microcins have the rare ability to bind Gram-negative bacterial surface proteins and transport themselves across the outer membrane to inhibit essential targets hidden underneath. We lack an understanding of how microcins encode these remarkable abilities in their short protein sequences. We will uncover microcin domains important for each stage of their action and how variations in their surface receptor binding controls their spectrum of activity, which will support the future development of innovative antibiotics.

PI_NAMEs: DAVIES, BRYAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active Biological Transport;Amino Acid Sequence;Anti-Bacterial Agents;Antibiotics;antimicrobial;Bacteria;Bacterial Proteins;bacteriocin;Binding;Bioinformatics;Biological Assay;Biology;Cells;Characteristics;Clinical;combat;Computing Methodologies;Coupled;Coupling;Data;Development;empowerment;Enterobacteriaceae;Equus caballus;Escherichia coli;Exclusion;Future;Gram-Negative Bacteria;Growth;human pathogen;in silico;in vivo;Infection;innovation;Invaded;Investigation;Knowledge;Link;Maps;Membrane;Membrane Proteins;Methods;microbial community;microcin;Multiple Bacterial Drug Resistance;novel;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Permeability;Phylogenetic Analysis;Prevalence;prevent;Proteins;receptor;receptor binding;Research;Route;scaffold;screening;siderophore receptors;Siderophores;Surface;System;tool;Transport Process;Validation;Variant;Work

PROJECT_TITLE: From microcin sequence to function: linking sequence variation to antimicrobial activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: NARRATIVE Clostridioides difficile (C. difficile) infection leads to substantial patient suffering and treatment cost because it is difficult to fully eradicate using antibiotics. In this work, we propose to design and optimize short proteins (peptides) that block the ability of C. difficile to damage tissue and deliver these peptides to the site of disease using probiotic yeast. This approach advances beyond current treatment methods due to its low cost, high specificity, and applicability to other gut infections.

PI_NAMEs: CROOK, NATHAN C. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affinity;Anabolism;Animal Model;Animals;anti-toxin;Antibiotic Resistance;Antibiotics;Antibodies;Binding;Binding Proteins;Binding Sites;Biodistribution;Biological;Biological Assay;Biological Response Modifier Therapy;Bioreactors;Blocking Antibodies;Cell Culture System;Cell Culture Techniques;Cell Physiology;Cell surface;Cell Surface Proteins;Cell Survival;Cells;Clinical;Clostridium difficile;Colitis;Colon;Complement;cost;delivery vehicle;design;Diarrhea;Diffusion;Disease;Engineered Probiotics;Engineering;Epithelial Cells;Epithelium;Experimental Designs;fecal transplantation;Fermentation;Fluorescence Resonance Energy Transfer;Foundations;Gastrointestinal tract structure;Glucosyltransferase;glycosylation;Histology;Human;in silico;in vitro Assay;Infection;Inflammation;inhibitor;insight;Kinetics;Knock-out;Knowledge;Lead;Measures;Mediating;Methods;Microfluidics;Modeling;Molecular;monolayer;Mucous body substance;Mus;novel therapeutics;opportunistic pathogen;Patients;Peptide Hydrolases;peptide L;Peptides;Permeability;Prevalence;Probiotics;Protein Family;Proteins;Publishing;rational design;receptor binding;Receptor Cell;Recurrence;resident commensals;resistant strain;rho;Risk;Route;screening;Site;Specificity;Structure;System;Testing;Therapeutic;Tissues;Toxic effect;Toxin;trafficking;Translating;transplantation therapy;Treatment Cost;Treatment Efficacy;Virulence Factors;Weight;Work;Yeasts

PROJECT_TITLE: Neutralizing C. difficile toxicity with probiotics that secrete rationally-designed inhibitory peptides.

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Rare Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project narrative  We recently found that certain point mutations to prevent expression of hepatitis B virus large envelope protein markedly increased polymerase-large envelope fusion protein, a product of RNA splicing. We will investigate whether this protein can also be increased by naturally occurring mutations selected at the late stage of chronic HBV infection, and establish its functional properties.

PI_NAMEs: TONG, SHUPING  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Accidents;Acute Hepatitis;Affinity;Antibody Response;Applications Grants;Back;Binding;Binding Sites;Cell Culture Techniques;Chimeric Proteins;Chronic;Chronic Hepatitis B;chronic infection;Chronic Phase;Clinical;clinically relevant;clinically significant;Core Protein;Cytomegalovirus;Detection;DNA Viruses;Dose;env Gene Products;experimental study;extracellular;Genes;Genetic Transcription;Genome;Genotype;Glycine decarboxylase;Hepatitis;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Virus;hepatitis B virus L protein;immune clearance;In Vitro;Infection;Introns;Malignant neoplasm of liver;Mediating;Monitor;Morphogenesis;mutant;Mutate;Mutation;Nonsense Mutation;Nucleosome Core Particle;Open Reading Frames;particle;Patients;pgRNA;Pilot Projects;Point Mutation;Polymerase;prevent;Primary carcinoma of the liver cells;Production;promoter;Property;protein expression;Protein Secretion;Protein Splicing;Proteins;receptor binding;Regulation;Ribosomes;RNA;RNA Splicing;Role;Sampling;Scanning;Serum;Site;Source;Surface;Testing;Transcript;Transfection;Translating;Translation Initiation;Translations;Variant;Viral;Viral Genome;Viral Proteins;Virion;Virus;Virus Diseases;Virus Receptors

PROJECT_TITLE: A splicing-generated protein of hepatitis B virus in chronic viral infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Narrative Retroviruses integrate their DNA into the host DNA genome by the viral-encoded integrase, thus permanently changing the virus-infected cell. Assembly mechanisms of integrase multimers on the viral DNA ends producing intasomes that catalyze concerted integration are essentially unknown. We will use single-particle cryo-electron microscopy with biochemical and virological studies to determine the structure and assembly mechanisms of retrovirus intasomes using Rous sarcoma virus as a model system.

PI_NAMEs: PANDEY, KRISHAN KUMAR (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Affect;Architecture;Betaretrovirus;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biophysics;C-terminal;Cells;Chicken Cells;Complex;conformational conversion;Cryoelectron Microscopy;Data;dimer;Distal;DNA;DNA Binding;DNA Integration;Electron Microscopy;experimental study;flexibility;Genome;Goals;Higher Order Chromatin Structure;HIV-1 integrase;Human T-lymphotropic virus 2;improved;In Vitro;in vivo;Infection;inhibitor;insight;Integrase;Knowledge;Lentivirus;Measures;Mediating;Missense Mutation;Molecular Conformation;Morphology;Mouse Mammary Tumor Virus;Movement;Mutagenesis;mutant;Mutation;Negative Staining;novel;particle;Pathway interactions;Phenotype;Physiological;pleiotropism;Point Mutation;Property;prototype;Resolution;Retroviridae;Reverse Transcription;RNA-Directed DNA Polymerase;Role;Rous sarcoma virus;Route;Simian T-lymphotropic virus 2;Spumavirus;Structure;System;Tail;three dimensional structure;tool;Transmission Electron Microscopy;Viral;viral DNA;Viral Genome;Virion;Virus;Virus Integration;Virus Replication;Visna;Western Blotting;X-Ray Crystallography

PROJECT_TITLE: Assembly mechanisms of Rous sarcoma virus intasomes.

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: NARRATIVE  This supplemental project seeks to advance our understanding of how Treg cells modulate effector, exhausted and memory T cell responses during BTE immunotherapy. This new knowledge gain will fuel newer combination regimens aimed at augmenting the therapeutic efficacy of BTEs by promoting anti-tumor effector and memory T cell responses in immunologically cold tumors characterized by paucity of T cells, while simultaneously mitigating bystander toxicity. These studies are of high significance to treatment of several pediatric and adult cold tumors such as neuroblastomas, gliomas, sarcomas and melanomas.

PI_NAMEs: KALIA, VANDANA ;OLSON, JAMES M (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Adult;Agonist;Antigens;Antitumor Response;Autoimmunity;Automobile Driving;Award;B-Cell Acute Lymphoblastic Leukemia;bi-specific T cell engager;Biological Assay;Bite;Blocking Antibodies;Body Weight;Bypass;C57BL/6 Mouse;cancer cell;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;Cell Death;Cell Physiology;Cells;Central Nervous System Neoplasms;Child;Childhood;Childhood Solid Neoplasm;clinical development;Clinical Trials;Combined Modality Therapy;CTLA4 gene;cytokine;Cytokine Suppression;cytotoxic;Cytotoxic T-Lymphocytes;Data;diffuse midline glioma;effector T cell;Equilibrium;exhaust;exhaustion;Foundations;Future;Glioma;Goals;Granzyme;Hematologic Neoplasms;Immunity;Immunocompetent;Immunologics;immunomodulatory strategy;immunoregulation;Immunotherapy;improved;in vivo;Infection;Inflammatory;interest;Knowledge;Lymphocyte Suppression;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Melanoma;Memory;Modeling;Molecular;Mus;Mutation;Neuroblastoma;Non-Small-Cell Lung Carcinoma;Pathway interactions;Pediatric Hematology;perforin;Phenotype;Preparation;primary endpoint;Production;programmed cell death ligand 1;Publishing;recruit;Regimen;Regulation;Regulatory T-Lymphocyte;Relapse;response;restoration;Role;Safety;Sarcoma;secondary endpoint;Signal Transduction;Solid Neoplasm;stem;synergism;systemic toxicity;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapy outcome;Toxic effect;trafficking;Treatment Efficacy;tumor;tumor ablation;Tumor Burden;tumor microenvironment

PROJECT_TITLE: Immunoregulatory Mechanisms of BiTE Efficacy in the Cold Neuroblastoma TME


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Our overall goal is to understand how various patient-specific features of colorectal cancer (CRC) and its tumor-immune microenvironment (TIME) govern differential responses to different types of immunotherapies using novel in vitro ‘avatars’ of the tumor-immune circuit (‘TIvitars’) that we developed as the first aim of our parent grant. To accomplish this, we will establish and perform immunotherapy screens using human CRC tissues from 20 patients comparing responses of each tumor to a broad range of immunomodulators that can (a) compare efficacy among numerous therapies for each patient’s tumor in a response- predictive way, and (b) correlate these responses with the molecular and cellular characteristics of each tumor (obtained from standard -omics analysis of the samples) as well as with the patient’s microbiome (obtained from sequencing stool samples). The resulting data will form a completely unique dataset whereby standard -omics data from cancer patients will be coupled with differential immunotherapy responses for each.

PI_NAMEs: SWARTZ, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: anti-tumor immune response;biobank;Cancer Patient;Characteristics;checkpoint inhibition;Clinical Data;Clinical Trials;colon cancer patients;Colorectal Cancer;comparative efficacy;Complex;Coupled;Data;Data Set;Gene Expression Profile;Goals;gut microbiota;Human;Immune;immune cell infiltrate;Immune response;immunological status;Immunomodulators;Immunotherapy;In Vitro;interest;Link;microbiome;microbiome analysis;microbiota;Modeling;Molecular;Mutation;novel;Operative Surgical Procedures;parent grant;patient response;Patients;Population;predicting response;Predisposition;response;Running;Sampling;Scientist;stool sample;Tissues;tumor;tumor-immune system interactions;Work

PROJECT_TITLE: Immuno-modeling in human colorectal cancer: linking in vitro immunotherapy responses with multiparameter characterization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(08)-F]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Head and Spine Injury

ORG_CITY: Irvine

ORG_NAME: NEURAEGIS, INC.

ORG_STATE: CA

PHR: A. Significance The significance is the same as in the original application. C. Approach C1. Specific Aim #1. To determine the optimal dose of NA-112 providing neuroprotection in two mouse models of epilepsy. C1.1. Rationale.  We have selected two mouse models to evaluate the role of calpain-2 activation as the triggering mechanism in the development of epilepsy. No model perfectly reproduces all the features of the human disease; however, models provide critical information regarding the underlying mechanisms that could be targeted in the human disease. Repeated injections of low doses of KA or pilocarpine in C57Bl/6 mice will be used as models of epilepsy because they both lead to the appearance of SRS, are amenable to animal implantation with EEG-recording equipment and have a high degree of animal survival (11-12). We have shown that NA-112 is neuroprotective in the repeated low doses of KA mouse model and that intranasal NA-112 administration in mice results in brain calpain inhibition. This aim will determine the optimal dose of intranasal NA-112 providing neuroprotection in both models of epilepsy. C1.2. Preliminary Results C1.2.1. Effects of NA-112 in the repeated low doses of KA epilepsy model.  We recently completed a series of experiments to determine the role of calpain-2 in the development of pathological manifestations of SE in mice. Our findings have been published in Neurobiology of Disease (9), and only a summary of the results is reported below. - KA model of epilepsy: All mice received three, consecutive, ip injections of kainic acid (5 mg/kg) every 20 min (10, 24) and were video-recorded for seizure analysis. - Mice: We used WT (C57BL/6J), calpain-2 conditional knockout (C2CKO, CamKII-Cre+/- CAPN2loxP/loxP) with deletion of calpain-2 in all excitatory neurons of the forebrain, and control (CAPN2loxP/loxP) mice. In addition, other groups of C57Bl/6J (WT) mice received daily ip injections of NA-112 (0.3 mg/kg/day) or vehicle (60 mg/kg/day of β-cyclodextrin) for 7 days starting 2 h after seizure initiation. - All mice exhibited SE and we did not observe any mortality with this protocol up to 7 days after KA-induced SE. There were no significant differences between any group for latency to first seizures, duration of first seizures and cumulative duration of stage 3-5 seizures. This is important, as it indicates that calpain-2 deletion or inhibition does not influence the initiation or duration of seizures, but rather the processes leading to neurodegeneration and neuroinflammation. - Seven days after seizure onset, numerous degenerating neurons were observed in hippocampus of WT animals, especially in the hilus of the dentate gyrus, identified as mossy cells; C2CKO mice were almost completely devoid of degeneration in all hippocampal subfields. Similar neuroprotective results were found when WT mice were treated daily with ip injections of NA-112. - Calpain-2 activation was detected in mossy cells up to 7 days after KA injection, and this activation was absent in C2CKO mice or in mice treated with NA-112. There was a clear correlation between calpain-2 activation in mossy cells with mossy cell death in WT mice. - KA-induced seizures resulted in strong astroglial and microglial activation in WT mice 7 days after KA-induced SE. Daily ip injections of NA-112 eliminated both astroglial and microglial activation. Similar results were found in the C2CKO mice. The prolonged duration of calpain-2 activation suggests that the window for intervention with a selective calpain-2 inhibitor following SE will be quite broad, although this will need to be further assessed in the Phase II of this STTR. - Cognitive performance was assessed by determining context-and tone-dependent memory in fear conditioning (FC) 7 days after seizure activity. Hippocampal-dependent contextual and tone memory was significantly impaired in WT and CAPN2 loxP (control) mice but not in C2CKO mice after seizures. Likewise, there was no significant impairment in mice treated daily with ip injections of NA-112. These results strongly support the premise that a selective calpain-2 inhibitor could be beneficial to prevent many of the neuropathological consequences of SE. - Blood P13BP levels are elevated after KA-induced seizures. We analyzed plasma levels of P13BP 24 h after KA-induced seizures (Fig. 1). P13BP blood levels were greatly  elevated 24 h after KA-induced seizures in WT but not in C2CKO mice. Similar  results were found in WT mice treated with NA-112 administered ip 3 h after SE  (not shown). Figure 1: Plasma levels of P13BP 24 h after KA-induced seizures. Blood was collected 24 h after KA-induced seizures and aliquots of plasma processed for western blot analysis of PTPN13 (WES system). The fragment migrating at 150 kDa is referred to as P13BP and quantified. Results are means ± S.E.M. of 6 animals. *** p < 0.001; **** p < 0.0001. One way ANOVA followed by Bonferroni test.  C1.2.2. Intranasal delivery of NA-112 inhibits brain calpain-2 activation.  We tested the effects of intranasal administration of various does of NA-112 on calpain-2 activity in anasal NA-112 prevents KA-induced hippocampal calpain  hippocampus 24 h after the administration (Fig. 2). Calpain-2 activation was completely prevented at the lowest  activation in mice  dose tested (0.1 mg/kg). Higher doses further decreased calpain-  * 2 activation to levels lower than those seen in control conditions  suggesting that NA-112 inhibits basal levels of calpain-2 activity.  Figure 2: Intranasal NA-112 prevents KA-induced hippocampal  calpain-2 activation in mice. Repeated low doses of KA (5 mg/kg) were  administered to adult mice. NA-112 was administered intranasally 2 h  after the end of seizure activity. Animals were sacrificed 24 h later and  ‡ the hippocampus was dissected and processed for immunoblotting with  ‡ a spectrin antibody. The ratios of SBDP/spectrin were analyzed. Results  ‡ are means ± SEM of 4 experiments. Statistical analysis was performed vs control with ANOVA with post-hoc comparisons. * p< 0.001 vs cont. ‡ p < 0.01 1 vs KA vs KA. Cont KA KA+NA-112 KA+NA-112 KA+NA-112  (0.1 mg/kg) (0.3 mg/kg) (1.0 mg/kg)  does of NA-112 on the plasma levels of ntranasal NA-112 potently prevents KA-induced increase in  he pattern of results was very similar to  plasma P13BP levels  NA-112 prevents KA-induced increase in * BP in mice. Repeated low doses of KA (5  red to adult mice. NA-112 was administered  the end of seizure activity. Animals were  nd plasma was collected an processed for  TPN13 antibody. The levels of the 130 kD  esults are means ± SEM of 4 experiments.  as performed with ANOVA with post-hoc  1 vs cont. ‡ p < 0.01 vs KA.  ‡  ‡  ‡ *p< 0.001 vs control ‡ p < 0.001 vs KA C1.3. Design and Experimental Approach. These are identical to those presented in the original application. Rigor in experimental design and statistical analysis.  All studies will be done in a blinded fashion, with the examiners analyzing the data blind to the experimental groups. Animal ID will be revealed after initial data analysis for group means and statistical analyses. All experiments will be performed with male and female mice. As mentioned above, there might be some differences for some of the outcome measures; in this case, data will be analyzed separately. When no obvious differences in outcome measures are observed, the data will be combined. The number of experiments we are proposing is based on our own as well as on previously published studies indicating it should be sufficient to detect significant differences between experimental groups. Statistical differences will be calculated with Student’s t-test when comparing 2 conditions. When comparing more than 2 conditions, ANOVA followed by Bonferroni tests will be used to determine statistical significance. Justification for the supplemental funding. This supplemental funding is requested to cover the additional cost to purchase the equipment needed to perform the proposed experiments, which is a combined video-EEG recording equipment from Biopac. As can be seen in the below email from Biopac, the original quote of $87,898 was missing some essential parts. These parts are essential for the completion of the experiments, and the fact they were not included in the initial quote was completely unexpected. At present, there is no fund in the current budget to cover this additional expense and we are already working with the minimum budget we need to complete the proposed experiments. From: Aimee Walker <aimeew@biopac.com> Sent: Friday, August 25, 2023 11:35 AM To: 'Michel Baudry' <mbaudry@westernu.edu> Subject: RE: Quote #99165 from BIOPAC Hi Dr. Baudry, WOW! Congratulations!! I just left you a voicemail, but give me a call when you have a moment so we can update your quote with current expiration dates, etc: 408-656-9287 The pricing is still the same as when we last connected, but I see a missing MP160 on the last version of the quote I sent in March (only 1 instead of 2). Did you submit the quote as it was or did you add in the second MP160 to your gran submission? Anyways, give me a call and we will sort it out. Looking forward to working with you on this! Aimee Walker – West Coast Sales Executive BIOPAC Systems, Inc. | 42 Aero Camino | Goleta, CA 93117 Tel: 805.685.0066 x 141 | Fax: 805-685-0067 Calendly: https://calendly.com/aimeew_biopac The original budget was indeed based on this quote. I am also providing below the original and the revised quotes. The difference in the quotes is $19,487.39, which is the requested budget. There is no overhead cost or fee associated with this supplemental budget, which is for an equipment, which will be purchased by the subcontractor, Western University of Health Sciences, and will remain there at the completion of the project.

PI_NAMEs: BAUDRY, MICHEL  (contact);BI, XIAONING

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acute;Adult;Aliquot;Analysis of Variance;Animals;anti-epileptic agents;Antibodies;Antiepileptogenic;Appearance;beta-Cyclodextrins;Biotechnology;blind;Blinded;Blood;Brain;Brain Concussion;Brain Injuries;Budgets;C57BL/6 Mouse;Calcium;calmodulin-dependent protein kinase II;Calpain;calpain inhibitor;Cell Death;Cells;cognitive performance;conditional knockout;conditioned fear;cost;Data;Data Analyses;dentate gyrus;design;Development;Disease;Dose;Drug resistance;Electroencephalography;Electronic Mail;Encephalitis;Epilepsy;Epileptogenesis;Equipment;equipment acquisition;Event;excitatory neuron;Exhibits;Experimental Designs;experimental group;experimental study;expiration;Family;Fas-associated phosphatase-1;Fees;Female;Frequencies;Funding;glial activation;Head;Health Sciences;Hippocampus;human disease;Impaired cognition;Impairment;implantation;inhibitor;Injections;Injury;Intervention;Intranasal Administration;Intraperitoneal Injections;Kainic Acid;Knockout Mice;Laboratories;Learning;Left;male;Memory;Migraine;migration;Modeling;mortality;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurobiology;neuroinflammation;Neuronal Injury;Neurons;neuropathology;neuroprotection;novel;Outcome Measure;Pathologic;Patient Compliance;Patients;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilocarpine;Plasma;prevent;Price;Process;Prosencephalon;Protein Isoforms;Protocols documentation;Publishing;Rattus;Recurrence;Reporting;Role;Route;Sales;Seizures;Series;side effect;Small Business Technology Transfer Research;Sorting;Spectrin;Statistical Data Interpretation;Status Epilepticus;Stroke;Students;System;Telefacsimile;Testing;Therapeutic;therapeutic target;Traumatic Brain Injury;Universities;Update;Video Recording;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Testing the effects of a selective calpain-2 inhibitor on spontaneous recurrent seizures in mouse models of epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(14)-B]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Microglia are innate immune cells of the brain, which sense neuronal activity. How microglia come to alter neuronal activity in response is critical basic knowledge with long-term therapeutic potential.

PI_NAMEs: WU, LONG-JUN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Anesthesia procedures;Brain;brain cell;Brain Diseases;Calcium;Cells;Central Nervous System;Complex;conditional knockout;Coupled;Electron Microscope;Epilepsy;experience;Genetic;Hyperactivity;Immune;in vivo two-photon imaging;Knowledge;Microglia;neural circuit;neuronal circuitry;Neurons;neurotransmission;Norepinephrine;Outcome;Pathway interactions;Process;Purines;receptor;reconstruction;Research;response;Seizures;Severities;Signal Transduction;Sleep Disorders;Slice;Therapeutic;tool;Virus

PROJECT_TITLE: How microglia sense and regulate neuronal activity in the adult brain


PI_NAMEs: DEY, NEELENDU ;GRADY, WILLIAM MALLORY (contact)

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Atlases;Basic Cancer Research;Behavior;Biological Aging;Biological Markers;Biology;Cancer Etiology;cancer genetics;Cancer Research Project;cancer type;Cells;Cessation of life;Clinic;Clinical;clinical application;cohort;Collaborations;Colon;colon cancer patients;Colonic Adenoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Data Set;deep sequencing;DNA Sequence Alteration;dysbiosis;Epigenetic Process;Epithelial Cells;experience;Fibroblasts;Gene Mutation;Goals;gut microbiome;Human;human disease;Immune;Individual;Indolent;innovation;Lesion;Light;Malignant Neoplasms;methylation pattern;methylome;microbial;microbiome;Mission;Molecular;mouse model;Multiomic Data;mutant;Mutation;Natural History;novel;Pathogenesis;Patients;Persons;Positioning Attribute;premalignant;Recording of previous events;Research Personnel;risk prediction;Science;senescence;Sessile Lesion;Technology;Testing;Tissues;translational cancer research;Translational Research;Translations;Tumor Promotion

PROJECT_TITLE: Identifying Gut Microbial Inducers of Biological Aging in the Colon


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Contact PD/PI: Allen, Todd M. Project Narrative: This study will determine whether we can develop HIV-specific allogeneic chimeric antigen receptor (CAR) T cells capable of evading recipient allorejection and controlling HIV replication in the absence of ART towards a functional cure for HIV. Project Narrative Page 7

PI_NAMEs: BOUTWELL, CHRISTIAN L. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acceleration;Allogenic;anti-viral efficacy;antiretroviral therapy;Autologous;base editing;CAR T cell therapy;CD28 gene;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Characteristics;chimeric antigen receptor T cells;Chronic;chronic infection;Consumption;Data;Development;Genetic;Hematopoietic Neoplasms;Heterogeneity;HIV;HIV Infections;Human;human disease;humanized mouse;Immune system;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Individual;Infection;Infusion procedures;interest;Macaca mulatta;manufacturing cost;Modification;Morbidity - disease rate;mortality;mouse model;novel;Patients;Resistance;response;SIV;Source;T cell response;T-Lymphocyte;Testing;Time;Viral;Viral Load result;Virus

PROJECT_TITLE: Development of Allogeneic CAR T Cell Therapy for a Functional Cure of HIV Infection


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: No PHR

PI_NAMEs: ZENG, LI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adult;Affect;afferent nerve;Afferent Neurons;Age;aggrecan;aggrecanase;Biological Assay;Bone Marrow;Bone plates;Bone Spur;C57BL/6 Mouse;Calcium;Cartilage;cell type;Cells;Chymase;Coculture Techniques;collagenase 3;Connective Tissue;Culture Media;Data;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;experimental study;Filament;Growth;Histamine;Histologic;Human;Image;Immune;In Vitro;in vivo;Incubated;Infiltration;Inflammation Mediators;Injections;Injury;Institutional Review Boards;Interstitial Collagenase;Intra-Articular Injections;joint injury;Joints;Knee;Knee joint;Location;Medical center;MMP9 gene;Modeling;Mus;neoantigens;Nerve;Nerve Fibers;Neurons;Nociception;Operative Surgical Procedures;Orthopedics;osteoarthritis pain;Outcome Measure;Pain;pain behavior;Papain;Peritoneal;Procedures;Proteins;Proto-Oncogene Protein c-kit;Protocols documentation;Regulation;Replacement Arthroplasty;response;Role;Rotation;Severities;Sorting;Spinal Ganglia;Stains;subchondral bone;Substance P;success;Surface;Surgeon;Synovitis;Testing;Thick;Time;Tissues;Tolonium chloride;treatment group;TRPV1 gene;Tryptase;Viral;Visualization;Withdrawal;Work;young adult

PROJECT_TITLE: The role of Wnt7a in orchestrating immune cell-driven osteoarthritis pain


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: ASOCIACION CIVIL IMPACTA SALUD Y EDUCACN

PHR: PERU CTU April 2024 PROJECT NARRATIVE The PERU Clinical Trials Unit (CTU)´s overarching goal is to contribute to the design and implementation of the scientific agenda of the US NIH/NIAID/DAIDS research networks, across the continuum from prevention to treatment, to decrease new HIV infections, reduce HIV associated morbidity and mortality, and ultimately end the HIV epidemic. Given the high tuberculosis incidence in Peru, with high burden of resistant strains, the PERU CTU is in an advantageous position to collaborate in the design and implementation of interventions to control the TB epidemic.

PI_NAMEs: LA ROSA, ALBERTO ;SANCHEZ, JORGE LUIS (contact)

PROGRAM_OFFICER_NAME: GUERRA, MARIA ISABEL

PROJECT_TERMS: 3-Dimensional;AIDS clinical trial group;clinical implementation;Clinical Research;clinical research site;Clinical Trials Network;Clinical Trials Unit;Collaborations;Complex;design;Epidemic;Ethics;experience;Goals;HIV;HIV Infections;HIV prevention trials network;HIV Vaccine Trials Network;HIV/AIDS;implementation intervention;Incidence;Infrastructure;innovation;Institution;Investments;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;operation;Peru;Positioning Attribute;Prevention;Research;Research Personnel;resistant strain;Resources;tool;Tuberculosis;United States National Institutes of Health;Update;vaccine trial

PROJECT_TITLE: PERU Clinical Trial Unit


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: LYNDEN

ORG_NAME: CORNERSTONE SYSTEMS NORTHWEST, INC.

PI_NAMEs: SHERRITT, LON  (contact)

PROJECT_TERMS: Cancer Intervention and Surveillance Modeling Network;Cancer Model;cohort;comparative;Contractor;Data;Division of Cancer Control and Population Sciences;flexibility;Infrastructure;Knowledge Management;Malignant Neoplasms;Modeling;models and simulation;National Cancer Institute;Natural History;Online Systems;Structure;Surveillance Modeling;System;Work

PROJECT_TITLE: CORE INFRASTRUCTURE TASK ORDER FOR CISNET CONSORTIUM FOR CANCER SURVEILLANCE MODELING SUPPORT


NIH_SPENDING_CATS: Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PI_NAMEs: NA, NA  (contact)

PROJECT_TERMS: Anti-Infective Agents;Area;Bacterial Vaginosis;Chlamydia;Clinical;Clinical Trials Design;Communicable Diseases;Consultations;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;Data;design;Development;Development Plans;drug development;Ensure;Ethics;experience;Experimental Designs;Extramural Activities;Funding;good laboratory practice;Government;Grant;HIV;HIV/AIDS;meetings;men;Methods;Monitor;National Institute of Child Health and Human Development;participant safety;pathogen;Pharmacology;Phase;Phase I Clinical Trials;Policies;pre-clinical;preclinical development;Pregnancy;prevent;Prevention;Procedures;product development;Program Development;Property;Protocols documentation;Recommendation;Reporting;reproductive;Research;research facility;Research Personnel;Risk Assessment;Safety;Services;sexual and reproductive health;Sexually Transmitted Diseases;Technology;Toxicology;U-Series Cooperative Agreements;virology;Woman;Work

PROJECT_TITLE: NICHD SERVICE: PRODUCT AGNOSTIC SUPPORT FOR ADVANCING MULTIPURPOSE PREVENTION TECHNOLOGIES OF CONTRACEPTION RESEARCH


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE MEMORIAL INSTITU

PI_NAMEs: FALLACARA, DAWN  (contact)

PROJECT_TERMS: Adverse effects;Benzene;carcinogenicity;Chemicals;Data;design;Development;disorder prevention;Environmental Exposure;exposure route;Exposure to;Goals;Hazard Identification;Hazardous Chemicals;Health;Human;Inhalation;Laboratories;Laboratory Animals;Lung;Mission;Mus;neurobehavioral;Phase;public health research;Rattus;reproductive;Risk Assessment;Risk Factors;sound;Toxic effect;Toxicity Tests;Toxicology;Xylene

PROJECT_TITLE: Conduct of studies to evaluate the toxic potential of mixed xylenes in laboratory animals


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Adverse effects;Amphiboles;Asbestos;carcinogenicity;Chemicals;Chronic;Data;design;Development;disorder prevention;Environmental Exposure;Exposure to;Fiber;Goals;Hazard Identification;Hazardous Chemicals;Health;Histopathology;Human;Inhalation;Inhalation Exposure;Laboratory Animals;Lung;method development;Methods;Mineral Fibers;Mission;Nose;Phase;Preparation;public health research;Rattus;Reporting;Risk Assessment;Risk Factors;sound;Source;Tissues;Toxic effect;Toxicity Tests;Toxicology;Work

PROJECT_TITLE: Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos and related mineral fibers in laboratory animals


NIH_SPENDING_CATS: Endocrine Disruptors;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

PROJECT_TERMS: Adverse effects;Chemicals;consumer product;Data;design;Development;developmental neurotoxicity;developmental toxicity;disorder prevention;Dose;Environment;Environmental Exposure;Evaluation;Exposure to;Flame Retardants;General Population;Goals;Hazard Identification;Hazardous Chemicals;Health;Human;inorganic phosphate;Lactation;Mission;Perinatal Exposure;Phenols;Pregnancy;public health research;Rattus;Risk Assessment;sound;Toxic effect;Toxicity Tests;Toxicology;Weaning

PROJECT_TITLE: Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP)in rats (after perinatal exposure)


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Aerosols;Air;Air Pollutants;Animals;Cells;Complex Mixtures;Data;Data Correlations;design;Dryness;Evaluation;exposure route;Fiber;Goals;Government;Health Hazards;Human;In Vitro;in vitro testing;in vivo;Industrialization;Inhalation;Inhalation Exposure;Liquid substance;Lung;pilot test;Population;Powder dose form;programs;Rattus;System;Testing;Tissues;toxicant;Toxicity Tests;Toxicology;vapor

PROJECT_TITLE: Establish and Characterize an Air Liquid Interface In Vitro Exposure System


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PI_NAMEs: HEJTMANCIK, MILTON  (contact)

PROJECT_TERMS: animal data;Cardiotoxicity;Case Study;Chemicals;Data;design;Dose;Evaluation;Heart;Histopathology;Human;In Vitro;in vitro testing;in vivo;Literature;Monitor;Oral;Physiologic Monitoring;Publishing;Qualifying;Rattus;Testing;Toxic effect;Toxicology;transcriptomics;Translations

PROJECT_TITLE: Evaluation of Physiological Monitoring in Tocivology using 2-Ethyltoluene as a case study


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PHR: The objective of the contract for Resource to Advance Pediatrics and HIV Prevention Science is to provide the extramural scientific community with research materials and preclinical product development support for candidate products that emerge. The focus of these contracts will be development of therapeutics and prevention products for HIV, including single or combination products with activity against associated co-infections or MPTs that incorporate contraceptives.

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: AIDS prevention;Area;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Documentation;Extramural Activities;HIV;Investigator-Initiated Research;meetings;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;pre-clinical;Prevention;Private Sector;product development;quality assurance;Quality Control;Research;research clinical testing;research study;Resources;Science;Services;Support Contracts;therapeutic development

PROJECT_TITLE: Resource to Advance Pediatrics and HIV Prevention Science (RAPPS): Quality Assurance/Quality Control (QA/QC) Support


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: SMITH, KIMBERLY  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;AIDS clinical trial group;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;comparative efficacy;Exposure to;global health;high risk;HIV;Household;indexing;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;isoniazid;Mission;Monitor;Multicenter Trials;Multidrug-Resistant Tuberculosis;National Institute of Allergy and Infectious Disease;Newly Diagnosed;open label;Patients;Phase;Phase III Clinical Trials;prevent;Probability;Research Support;Resources;Safety;Services;Site;Time;United States Dept. of Health and Human Services;United States National Institutes of Health

PROJECT_TITLE: Clinical Trial Site Monitoring for PHOENIx MDR-TB


NIH_SPENDING_CATS: Genetics;Neurodegenerative

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Uncorrupted gene expression is critical to cell function and human health. Our cells encode a multitude of RNA quality control machineries that detect and degrade defective RNAs that have the potential to interrupt gene expression, some of which have been linked to neurodegenerative disorders. The objective of this proposal is to uncover the mechanisms whereby these pathways detect and degrade defective RNAs in human cells, and the consequences of defects in these pathways to cell function and human health.

PI_NAMEs: LYKKE-ANDERSEN, JENS  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 7SL RNA;Address;Biological Assay;Cell Physiology;Cells;Code;Defect;Failure;Gene Expression;Genetic Transcription;Goals;Health;Human;human disease;Human Genome;insight;Interruption;Learning;Link;Mediating;Messenger RNA;Monitor;mRNA Decay;Mutagenesis;Neurodegenerative Disorders;Pathway interactions;Play;Predisposition;Proteins;Pseudogenes;Quality Control;Research;RNA;RNA Processing;Role;Signal Recognition Particle;Small Nuclear RNA;Spliceosomes;Untranslated RNA;Variant

PROJECT_TITLE: Mechanisms of human RNA turnover and quality control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Neurosciences

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Medical Scientist Training Program (MSTP) is designed for trainees pursuing broad careers in research relevant to human health and disease. We seek to fulfill a national need for individuals who will apply clinical and research experience to biomedical investigation by providing trainees with access to the very best resources of the University, and by catalyzing the application of multidisciplinary approaches to solve the most pressing problems in medical science. The UChicago MSTPs’ distinctive interdisciplinary approach encourages trainees to explore their medical and research interests in the broadest possible terms in medicine, biology, and the physical sciences.

PI_NAMEs: CLARK, MARCUS RAMSAY (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;National Research Service Awards;Scientist

PROJECT_TITLE: Medical Scientist National Research Service Award

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Poly ADP ribose polymerase inhibitor (PARPi) have changed treatment paradigms, with greatest clinical benefits in BRCA mutant homologous recombination (HR) deficient ovarian cancer. A critical clinical problem is chemotherapy drugs, including PARPi, are far less effective in BRCA wild-type HR proficient ovarian cancer (e.g. CCNE1 amplification/gain). This proposal will apply an innovative translational research approach to determine the potential benefits of PARPi-epigenetic drug combinations for the treatment of poor prognostic ovarian cancer.

PI_NAMEs: KHABELE, DINEO  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Aftercare;antitumor effect;Back;Biological Assay;Biological Markers;Blood specimen;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Model;carcinogenesis;CCNE1 gene;Cell Line;cell type;Chemicals;chemotherapy;ChIP-seq;Clinic;Clinical;clinical development;Clinical Trials;clinically relevant;Combined Modality Therapy;companion diagnostics;Complement;Data;design;DNA Methyltransferase Inhibitor;Drug Combinations;effective therapy;epigenetic drug;Epigenetic Process;epigenetic therapy;Future;Gene Expression;gene function;gene repression;Genes;Genetic Transcription;genome-wide;Histone Deacetylase Inhibitor;homologous recombination;homologous recombination deficiency;In Vitro;in vivo;inhibitor;inhibitor therapy;innovation;insight;Knowledge;Malignant neoplasm of ovary;Measures;Methods;Molecular;mutant;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase I/II Clinical Trial;Phase I/II Trial;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;pre-clinical;Pre-Clinical Model;Precision Run-On Sequencing;preclinical development;prognostic;Publishing;Regimen;Repression;Resistance;response;response biomarker;Surrogate Markers;Testing;Therapeutic;Toxic effect;transcriptome sequencing;translational approach;Translational Research;tumor;Validation

PROJECT_TITLE: Epigenetic Drug Regimens for Homologous Recombination Proficient Ovarian Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE In clinical studies of tropical infectious diseases, there is a major gap between the emergence of novel designs of cluster-randomized trials (CRTs) and the development of corresponding statistical methods, which hampers the efficient estimation and valid interpretation of the intervention effect estimates. Exploiting advances in causal inference methods and computational tools, the applicant will improve the design and statistical analysis to achieve validity and efficiency for a wide range of infectious disease CRTs.

PI_NAMEs: WANG, BINGKAI  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Accounting;Address;arm;Award;Biometry;career;Caring;Clinical Research;cluster randomized design;Cluster randomized trial;Collaborations;Communicable Diseases;Complex;computerized tools;Cost efficiency;Data;Data Analyses;Dedications;Dengue;design;Developing Countries;Development;Disease Outbreaks;disorder control;Ebola;Equation;Equipment;Evaluation;Evaluation Studies;experience;Faculty;flexibility;Funding;Future;Goals;Graph;hands-on learning;Health Care Seeking Behavior;improved;Individual;Infectious Diseases Research;Influenza;innovation;Intervention;intervention effect;Intervention Studies;Kenya;Malaria;Meningitis;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Outcome;pathogen;Pathway interactions;Pennsylvania;Phase;Positioning Attribute;pragmatic trial;Procedures;Process;Randomized;randomized trial;recruit;Research;Research Personnel;Resources;Sample Size;simulation;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;summer institute;symposium;Symptoms;Techniques;tenure track;Testing;theories;Training;Training Activity;training opportunity;trial design;Universities;Vaccination;vector control;Wolbachia;Work

PROJECT_TITLE: Improving the design and statistical analysis of cluster-randomized trials on tropical infectious diseases


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurofibromatosis;Neurosciences;Nutrition;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE High grade gliomas are aggressive brain tumors that occur in children and, with limited therapeutic options, are highly lethal. We have discovered a novel function for a protein commonly mutated in pediatric high grade gliomas, which leads to distinct changes in metabolism of the neural progenitor and tumor cells. Our proposed study seeks to understand how this protein regulates lipid metabolism specifically, and whether this distinct change can be targeted to improve therapeutic intervention.

PI_NAMEs: GATESMAN, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: anti-cancer research;autosomal dominant mutation;Award;Brain;Brain Neoplasms;Cancer Etiology;cancer predisposition;cancer type;Cause of Death;cell growth;Cell membrane;Cells;Cellular Structures;Child;Childhood;childhood cancer mortality;Childhood Glioma;Chromatin;clinically relevant;cofactor;Data;Data Set;Dependence;Development;Environment;Enzymes;Epigenetic Process;Exhibits;fatty acid metabolism;Fatty Acids;Foundations;Genetic;Genetic Transcription;Glioma;glioma cell line;Gliomagenesis;Glycolysis;Goals;Growth;Hereditary Malignant Neoplasm;Heterozygote;histone modification;improved;In Vitro;in vivo;Individual;inhibitor;Intervention;Knowledge;Laboratory Research;lipid metabolism;lipidomics;Lipids;Lipoproteins;loss of function;Malignant Neoplasms;MAP Kinase Gene;Mentors;Metabolic;metabolic phenotype;Metabolism;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;Mutate;Mutation;neoplastic cell;nerve stem cell;Neurofibromatoses;Neurofibromatosis 1;Neurosciences;NF1 gene;NF1 mutation;novel;Nuclear Pore Complex;Null Lymphocytes;Oncogenic;overexpression;Pathology;Pathway Analysis;Pathway interactions;Patients;Persons;pharmacologic;Phase;Phenotype;Phospholipids;Play;Population;Postdoctoral Fellow;pre-doctoral;Predisposition;Production;protein function;Proteins;Proteomics;ras GTPase-Activating Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Research;Research Personnel;Risk;Role;Signal Transduction;Small Interfering RNA;Solid Neoplasm;Survival Rate;Syndrome;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;tumor;tumor behavior;Tumor Biology;tumor growth;tumorigenesis

PROJECT_TITLE: Neurofibromin 1 as a novel regulator of lipid metabolism