ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  CMV has a high global prevalence and is the leading cause of transplant related mortality. The proposed research will combine tools from DNA and protein based synthetic structural biology to construct (i) a biosensor that will allow transplant patients to self-screen for CMV at home, and (ii) a protein switch that will use CMV’s genetic signature to kill virally infected cells. This is the first attempt at combining technologies from two separate fields that have evolved independently, and the outcome of this project will pave the way for the construction of biomolecular switches using this hybrid approach for applications beyond the reach of each individually.

PI_NAMEs: SEKHON, HARSIMRANJIT S (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Anti-viral Agents;Anti-viral Therapy;aptamer;BCAR1 gene;Bioinformatics;Biological;Biosensor;Biotechnology;Bone Marrow;Bone Marrow Transplantation;Cause of Death;Cell Death;cell killing;Cell Physiology;Cells;Cellular Phone;Cessation of life;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Color;combat;cost;Cytomegalovirus;Cytomegalovirus Infections;design;Detection;detection limit;detection platform;Development;Devices;Diagnostic tests;Disease;DNA;DNA amplification;DNA Sequence;Elements;Engineering;Equipment;flexibility;Flow Cytometry;Genes;genetic signature;Goals;Herpesviridae;Home;home test;Human Resources;Hybrids;In Vitro;Individual;Induction of Apoptosis;Infection;inhibitor;innovation;interest;Luminescent Proteins;Mammalian Cell;Mediating;Methods;Molecular;Monitor;monocyte;mortality;Myelogenous;Nature;novel;Nucleic Acids;Oligonucleotides;Outcome;Output;Patients;Plasmids;point of care;Population;post-transplant;Prevalence;prevent;Process;prophylactic;Protein Engineering;Proteins;Quantitative Reverse Transcriptase PCR;Reaction;Research;Resource-limited setting;response;Ribonucleases;RNA;Sampling;screening;self assembly;Sirolimus;Special Equipment;structural biology;synthetic biology;System;Techniques;Technology;Temperature;Testing;Time;tool;Training;Transplant Recipients;Transplantation;Viral;viral detection;viral RNA;Virus;Virus Activation;Virus Replication

PROJECT_TITLE: Molecular Devices for the Detection and Treatment of HCMV Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: LEEDS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NORTHAMPTON VA MEDICAL CENTER

ORG_STATE: MA

PHR: More than 30,000 veterans are hospitalized for stroke each year, and in the critical first months of recovery, at least half are disabled by abnormal 3-D spatial function (spatial neglect). Their self-care, mobility, and ability to return home are severely limited. Worse, many of these veterans are never diagnosed, counseled about the problem, or prescribed spatial rehabilitation. Here, we attempt to speed up spatial neglect diagnosis, using the brain imaging that is always part of the first hours of stroke care. We will compare 4 methods to identify the special brain imaging features present in people with spatial neglect who respond to early rehabilitation, and who recover best at 3 and 6 months after stroke. Once we complete this study, the next step will be to confirm our findings in a larger project, to ensure clinical brain imaging can be used for treatment assignment in veterans across gender, race, and other characteristics.

PI_NAMEs: BARRETT, A. M. (contact)

PROJECT_TERMS: 3-Dimensional;acute stroke;Address;Affect;American Heart Association;anatomic imaging;associated symptom;Atlases;Awareness;Behavioral;Biological;Biological Markers;biomarker validation;Brain;Brain imaging;brain magnetic resonance imaging;Cardiac;care costs;care delivery;Caregivers;Caring;Characteristics;Clinical;clinical biomarkers;clinical imaging;clinical predictors;Cognition Disorders;Cognitive deficits;cognitive disability;cognitive rehabilitation;Communities;comparative;connectome;Consumption;Counseling;Data;design;Diagnosis;Diffusion Magnetic Resonance Imaging;disabled;Elements;Ensure;experience;Failure;Family Caregiver;Freedom;frontal lobe;functional disability;functional gain;functional improvement;functional independence;functional outcomes;Gender;Goals;high resolution imaging;Home;Hospitalization;Hour;Image;imaging biomarker;Imaging Techniques;improved;improved outcome;Injury;Lead;Left;Lesion;Life;Magnetic Resonance Imaging;Maps;Measurable;Measures;Methods;Motor;motor deficit;Movement;neural correlate;Neuroanatomy;Neurocognitive;neuroimaging;Neuropsychology;novel;novel strategies;observational cohort study;Outcome;Pathologic;Patients;Perception;personalized biomarkers;personalized care;Persons;post stroke;potential biomarker;predicting response;Process;Protocols documentation;Quality of life;Race;Recommendation;Recovery;Recovery of Function;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Personnel;Resolution;response;Rest;screening;Self Care;Serum;Site;skills;social;spatial neglect;Speed;statistics;Stroke;stroke outcome;stroke rehabilitation;stroke survivor;Structure;Supervision;Technical Expertise;Testing;Time;Translating;treatment planning;treatment response;Troponin;Veterans;white matter;white matter damage;Work

PROJECT_TITLE: A biomarker for personalized care in post-stroke spatial neglect

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: DENTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH TEXAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields. The project is relevant to NIH’s mission because it uses a novel multidisciplinary approach to enhance the health of the nation by creating tools that facilitate both medical-related discoveries and the implementation of new strategies for biomedical applications.

PI_NAMEs: CHAN, TSZ YAN CLEMENT  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;behavioral response;Biological;Biosensor;cell behavior;Cell Physiology;cellular engineering;Chemicals;Complex;design;Development;Devices;DNA;DNA Binding;Engineering;Family;Food Contamination;Gene Expression;Genetic;Genetic Transcription;Goals;Health;Hybrids;innovation;Intake;interdisciplinary approach;Ligand Binding;Medical;Mission;Monitor;monitoring device;novel;Organism;Outcome;Output;Performance;pollutant;programs;promoter;Property;Protein Engineering;Protein Family;Public Health;Qualifying;Research;Research Personnel;Safety;sensor;Signal Transduction;synthetic biology;System;tool;toxicant;United States National Institutes of Health;Water;Work

PROJECT_TITLE: Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Sensorineural hearing loss often involves the damage and retraction of auditory nerve fibers from the sensory epithelium within the cochlea. Regeneration of these auditory nerve fibers and reinnervation of the appropriate cell targets is limited in humans and other mammals. This study uses a zebrafish model to determine molecular cues and cellular behavior that may promote functional nerve regeneration to restore physiologic hearing.

PI_NAMEs: ROY, ROHAN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Nerve;Affect;afferent nerve;analog;Auditory;Axon;axon growth;axon regeneration;axonal pathfinding;Axotomy;Basement membrane;Brain;Brain-Derived Neurotrophic Factor;cell behavior;Cell membrane;Cell surface;Cells;Cochlea;Collagen;confocal imaging;Confocal Microscopy;Cranial Nerves;Cues;Data;deaf;deafness;Development;Doctor of Philosophy;Epithelium;experimental study;Extracellular Matrix;Fiber;Fishes;fluid flow;Fluorescence-Activated Cell Sorting;Ganglia;Genes;Genomics;Goals;Growth Cones;Hair Cells;Hearing;hearing impairment;hearing restoration;Human;Image;Imaging Techniques;in vivo;Individual;Inner Hair Cells;insight;Institution;Label;Labyrinth;Larva;lateral line;Mammals;mechanical signal;Mechanics;Memory;Mentorship;Microscopy;model organism;Modeling;Molecular;Natural regeneration;Nerve;nerve damage;Nerve Fibers;Nerve Regeneration;Nervous System;Neurites;neuromast;Neurons;neurotrophic factor;New York City;Olfactory Nerve;Organ;Organism;paracrine;Pathology;Persons;Physical environment;Physiological;Population;Positioning Attribute;prevent;programs;Publishing;Regenerative capacity;Regenerative research;reinnervation;Research Personnel;Resolution;restoration;Reverse Transcription;Role;Schwann Cells;Sensorineural Hearing Loss;Sensory;Sensory Hair;sensory mechanism;Signal Transduction;sound;Structure;supportive environment;Synapses;System;Testing;transcriptome sequencing;Transgenes;Transgenic Organisms;United States;Universities;Zebrafish

PROJECT_TITLE: Mechanisms of sensory hair cell reinnervation following lateral line cranial nerve damage in Danio rerio


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative This innovative proposal will study the complex relationship between stress, endocannabinoid signaling, and cocaine-seeking behavior by exploring projection-specific neuroadaptations within a translational behavioral model. The results of these multi-faceted experiments will expand our understanding of the mechanisms underlying the individual or combined effects of stress and cocaine use and could provide insight into mechanisms that enhance drug seeking behavior. Together, the proposed experiments will reveal new mechanistic understanding of stress and cocaine interactions for the purpose of developing better treatment for cocaine use disorder and other substance use disorders.

PI_NAMEs: GAULDEN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;Acute;addiction;Affect;American;antagonist;Area;Attenuated;attenuation;Behavior;behavior influence;Behavioral;Behavioral Model;Brain;cell type;CNR1 gene;Cocaine;cocaine craving;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Complex;Corticosterone;Data;Dedications;Disease;Disinhibition;Drug Interactions;drug seeking behavior;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;experimental study;FDA approved;Fiber;Goals;Health;hippocampal pyramidal neuron;Human;In Situ Hybridization;in vivo;Individual;innovation;insight;Intake;Interneurons;Knowledge;Measurement;Measures;Mediating;Modeling;Molecular;neuroadaptation;Neurobiology;Neurons;neurophysiology;neuroregulation;neurotransmission;Neurotransmitters;Nucleus Accumbens;Outcome;Output;Pathologic;Pathway interactions;Pattern;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Photometry;Population;Positioning Attribute;pre-clinical;Prefrontal Cortex;Prevalence;Rattus;Recording of previous events;Regulation;Research;Research Personnel;Rewards;Rodent;Role;Self Administration;Signal Transduction;Site;skills;Stimulus;Stress;stressor;Substance Use Disorder;System;Testing;Time

PROJECT_TITLE: Endocannabinoid regulation of the corticoaccumbens pathway and stress-enhanced cocaine-seeking behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-W(90)S]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of this proposal is to improve the guideline-concordant breast cancer (BC) screening among Latinas living in Chicago, by testing a new empowerment (empower) approach - wherein non-adherent Latinas are empowered to become informal breast health leaders in their community and are navigated to affordable, accessible care. We will examine if, relative to traditional approaches, the empower approach leads to greater BC screening among non-adherent Latinas and women in their social networks. We will also explore and identify the “active ingredients” that lead to greater BC screening in the empower approach - including greater knowledge, motivation to be a healthy role model, volunteerism in community BC initiatives, potential to “bridge” network members with formal change agents (e.g., community health workers, navigators), acceptability to promote BC, feasibility to promote BC, and BC promotion to network members.

PI_NAMEs: MOLINA, YAMILE  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Address;arm;Breast;Breast Cancer Detection;breast cancer diagnosis;cancer care;Caring;Chicago;Clinical;Collaborations;Communication;Communities;community engagement;Community Health Aides;Community Health Education;community intervention;community organizations;community research;comparison intervention;cost;Data;design;diagnosis quality;Education;Educational process of instructing;empowerment;Enrollment;Equation;experience;Family;Federally Qualified Health Center;Friends;Fright;Future;Goals;Guidelines;Health;Healthcare;implementation science;improved;Individual;innovation;Intervention;intervention effect;intervention participants;Knowledge;Latina;Latina Population;Latino;leadership development;Learning;Long-Term Effects;Malignant Breast Neoplasm;Mammography;Measures;Mediating;Mediation;member;Modeling;models and simulation;Motivation;novel;Pathway Analysis;peer;Pilot Projects;Population;Process;prospective;psychosocial;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Role;role model;screening;screening guidelines;Services;skills;skills training;Social Network;social observations;Solid;Testing;Translations;United States Preventative Services Task Force;volunteer;Woman

PROJECT_TITLE: Empowering Latinas to Obtain Guideline-Concordant Breast Cancer Screenings

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: JOHN JAY COLLEGE OF CRIMINAL JUSTICE

PHR: Relevance  Candida albicans is the major fungal pathogen of humans and 3rd most common nosocomial infective agent in the US alone with a high mortality rate amongst candidemia patients. The mitochondrion is critical for C. albicans adaptation, survival, and pathogenesis and is a major target for antifungal interventions. This proposal is relevant, as we will determine the role of an ancient protein family in mitochondrial function.

PI_NAMEs: RAUCEO, JASON MALCOLM (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: anti-fungal agents;Antifungal Therapy;Apoptosis;Apoptotic;Area;Binding Proteins;Biological Assay;Biology;Biomedical Research;Candida albicans;candidemia;Carbon;Cell membrane;Cell Physiology;Cell Wall;Cells;Cellular Assay;Cessation of life;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;college;Complex;cost effective;CRISPR/Cas technology;Death Rate;Disseminated candidiasis;drug efficacy;Drug usage;Epitopes;Eukaryota;Eukaryotic Cell;Exposure to;Family;Family member;Filament;flotillin;Flow Cytometry;Fluorescence Microscopy;Funding;fungus;gene discovery;Genes;Genetic;Genetic Transcription;genome editing;Goals;Growth;Hispanic-serving Institution;Human;human pathogen;Hyphae;in vivo;Infection;inhibitor;innovation;Intervention;Invertebrates;Investigation;Knowledge;Leishmania;Life;Life Cycle Stages;light microscopy;Mammals;Mediating;member;Membrane;Membrane Potentials;Membrane Proteins;microbial;Mitochondria;mitochondrial membrane;Molecular;Molecular Genetics;Morphogenesis;mutant;Nematoda;novel;Organelles;Osmosis;Oxidative Stress;Parasite Control;Parasites;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Phenotype;Phospholipids;Planarians;Plasmodium;Process;Production;Productivity;programs;prohibitin;Property;protein complex;Protein Family;protein function;Protein Sequence Analysis;Proteins;Proteomics;Publishing;Reactive Oxygen Species;Research;Respiration;respiratory;response;Role;Signal Transduction;Source;Stress;Study models;System;Testing;Time;Training;Underrepresented Students;Vertebrates;Virulence;Yeasts

PROJECT_TITLE: Control of Mitochondrial Function by SPFH Proteins in Pathogenic Yeast


NIH_SPENDING_CATS: Cancer

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: AMBULOS, NICHOLAS P (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;acronyms;anti-cancer research;Baltimore;Basic Science;biobank;Biological Sciences;biomedical resource;Biometry;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Catchment Area;Cigarette;Clinical;clinical care;Clinical Research;Clinical Trials;Communication;Comprehensive Cancer Center;Core Facility;cost;Data Analyses;Development Plans;Doctor of Philosophy;Ensure;Environment;expectation;Experimental Designs;Faculty;Feedback;Financial Support;Flow Cytometry;Fostering;Foundations;Funding;Future;genome sciences;Genomics;Grant;hormone related cancer;Image;Immunology;innovation;innovative technologies;instrument;instrumentation;interest;Investigational Therapies;Investments;Laboratories;Leadership;lectures;Malignant Neoplasms;Maryland;medical schools;meetings;member;Mission;Molecular Biology;nanopore;NCI Center for Cancer Research;neoplasm immunotherapy;new technology;novel;novel diagnostics;novel therapeutics;Online Systems;Pathology;Patient Care;Patients;Population Sciences;Process;programs;Quality Control;Research;Research Personnel;Resource Sharing;Resources;restraint;Role;Science;service delivery;Services;Strategic Planning;structural biology;Structure;success;Surveys;Technology;Translational Research;translational study;tumor immunology;Universities;Wages;Work

PROJECT_TITLE: Shared Resource Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Approximately 1 in 4 children under the age of 5 live with a mother who is the victim of intimate partner violence, which is a substantial threat to the health and well-being of children. Results of this work will inform policymakers, development workers, and public health professional about the effect of two types of social policies – intimate partner violence prevention legislation and cash transfer programs – on reducing intimate partner violence and improving child health in low- and middle-income countries.

PI_NAMEs: RICHARDSON, ROBIN  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 5 year old;Adopted;Adoption;adverse childhood events;Advocacy;Africa;Age;Area;Asia;Award;Belief;career;career development;Caregivers;Child;Child Health;Child Support;Child Welfare;Communities;contextual factors;Data;Decision Making;Demographic and Health Surveys;design;Development;econometrics;Education;empowerment;Epidemiology;Evaluation;experience;Exposure to;Female;Freedom;Goals;Grant;Growth;Health;health inequalities;health of the mother;Health Professional;Health Status;Health Surveys;High Prevalence;Home;Household;Household Heads;Human;Human Development;Impairment;improved;Income;India;Individual;Inequality;Intervention;intimate partner violence;Knowledge;Legal;Link;Literature;low and middle-income countries;Low income;Maternal Exposure;Mediating;Mediation;Mentors;Mentorship;Methodology;Methods;mortality;Mothers;National Institute of Child Health and Human Development;neglect;Pathway interactions;Personal Satisfaction;Phase;Policies;Policy Analysis;Policy Maker;Policy Making;population based;population health;Prevalence;prevent;programs;Public Health;Public Health Schools;Punishment;Religion;Research;Research Personnel;Risk;rural residence;social;Social Policies;sociodemographics;South Africa;Statutes and Laws;Surveys;Testing;Training;Travel;Universities;vaccine acceptance;Violence;violence prevention;Woman;Work;World Bank

PROJECT_TITLE: Evaluation of social policies to reduce intimate partner violence and improve child health in low- and middle-income countries


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Kaposi sarcoma herpesvirus (KSHV) infection can cause Kaposi’s sarcoma (KS), a major malignancy leads to mortality and morbidity in people living with HIV/AIDS. Saliva from people with HIV infection contains nanoparticle-like extracellular vesicles that increase KSHV infection. This research will help us find a new method to prevent KSHV infection and transmission in populations living with HIV and people with high HIV infection risks.

PI_NAMEs: JIN, GE  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-Dimensional;Aging;Animal Model;Body Fluids;cell type;Cells;Cetuximab;Culture Media;cytokine;Data;Development;Endosomes;Endothelial Cells;Endothelium;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;exosome;Extracellular Space;extracellular vesicles;gammaherpesvirus;Gene Expression;Goals;Herpesviridae Infections;Histologic;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Human;Human Herpesvirus 8;Immune;in vitro Model;in vivo;Incidence;Infection;infection risk;Inflammatory;Kaposi Sarcoma;Link;lytic replication;Malignant Neoplasms;Mediating;Methods;Mitogen-Activated Protein Kinases;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mucous Membrane;Multicentric Angiofollicular Lymphoid Hyperplasia;nanoparticle;novel therapeutic intervention;Oncogenic;Oral;Oral cavity;oral cavity epithelium;oral infection;Oral mucous membrane structure;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Play;Population;Predisposition;prevent;primary effusion lymphoma;Process;Publishing;Receptor Signaling;Research;response;Response Elements;RNA;Role;Route;Saliva;single-cell RNA sequencing;Stratum Basale;success;Syndrome;System;T-Lymphocyte;Testing;Tissue Model;Tissues;TLR3 gene;Tonsil;Transactivation;transcriptome;transmission process;Vascular Endothelium;Vesicle;Viral;Viral Genes;Virus;Virus Diseases

PROJECT_TITLE: Role of HIV in KSHV oral transmission


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PI_NAMEs: ZHOU, ZHAOLAN  (contact)

PROJECT_TERMS: 3-Dimensional;Acquired disability;Affect;Anxiety;Articulation;Behavior;behavior test;Behavioral;behavioral phenotyping;Biological Assay;Biological Models;Biometry;Blood;Brain;Cell Line;Cell model;cell type;Cells;Clinical;clinical translation;Communication;Communities;community center;Consultations;cost;CRISPR/Cas technology;Data Analyses;Data Collection;data integration;Data Science Core;design;Development;differentiation in vitro;Disease;Education;effective therapy;efficacy evaluation;Eligibility Determination;Equipment;Experimental Designs;experimental study;Exposure to;Fibroblasts;Functional disorder;gene editing technology;Gene Modified;Genes;Genetic;Genetic Diseases;Genetic Models;genome editing;genomic data;Genomics;Human;human induced pluripotent stem cells;human subject;Immunotherapy;improved;In Vitro;induced pluripotent stem cell;insight;Intellectual and Developmental Disabilities Research Centers;interest;Laboratories;Leadership;Learning;Lifestyle-related condition;Maintenance;Measures;member;Memory;Methodology;Methods;Microdissection;Mission;Modeling;Molecular;Monitor;Mood Disorders;Motor;Motor Activity;mouse model;Mus;Mutation;mutation correction;neural circuit;neurobiological mechanism;neuroimaging;neuromuscular;Neurons;novel;Organoids;Outcome Measure;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Performance;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Pluripotent Stem Cells;pre-clinical assessment;Pre-Clinical Model;preference;Procedures;Production;programs;Protocols documentation;Reagent;Reflex action;Reproducibility;Research;Research Personnel;response;Rodent;Rodent Model;Serum;Services;Sister;social;Social Interaction;Somatic Cell;stem cell model;Stimulus;Structure;Surveys;Symptoms;System;Techniques;Technology;Testing;Therapeutic Intervention;Tissue Harvesting;Training;Treatment Efficacy;Ultrasonics;Validation;Variant;Viral;Virus;vocalization;working group

PROJECT_TITLE: Preclinical Models Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Behavior often takes place in situations of motivational conflict, where opposing goals (i.e., consuming food and avoiding threats) occur simultaneously, requiring the appetitive and aversive elements to be weighed and integrated to guide choices. This proposal will use novel viral and imaging tools to dissect the role of dopamine and GABA neurons in the ventral tegmental area, a brain region critical for motivated behavior, in valence-based learning and decision making.

PI_NAMEs: STELZNER, MARGARET E (contact)

PROJECT_TERMS: Animals;Association Learning;Behavior;Behavioral;Brain region;Calcium;calcium indicator;Color;Computing Methodologies;Conflict (Psychology);Consumption;cost;Cues;Decision Making;Desire for food;Disease;Disinhibition;Dopamine;dopaminergic neuron;Elements;Environment;experience;experimental study;Fiber;Floor;FLP recombinase;food consumption;gamma-Aminobutyric Acid;Genetic;Goals;Halorhodopsins;Imaging Device;In Situ Hybridization;in vivo;insight;Learning;motivated behavior;Motivation;neurobiological mechanism;Neurons;neurotransmission;novel;optogenetics;Outcome;Photometry;Play;Population;Prevalence;Process;promoter;Rattus;recruit;response;Rewards;Role;selective expression;sensor;Shock;Signal Transduction;Stimulus;Sucrose;Synapses;Synaptic plasticity;Testing;Time;tool;Training;transmission process;Ventral Tegmental Area;Viral

PROJECT_TITLE: Resolving the role of VTA dopamine and GABA neurons in associative learning


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative It is estimated that 10-25% of human embryos have the wrong number of chromosomes, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of mistakes generated when female reproductive cells (oocytes) divide, yet surprisingly little is known about the mechanisms that underlie the vulnerability of oocytes to these errors. This project seeks to gain insight into this important question, focusing on the assembly and stabilization of a structure called the spindle that mediates the segregation of chromosomes during cell division.

PI_NAMEs: WIGNALL, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms of acentrosomal spindle assembly and stability during oocyte meiosis

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: NARRATIVE The goal of the K12 Career Development Program at City of Hope is to provide a structured, multidisciplinary approach to training junior faculty to become independent investigators capable of translating advances in molecular oncology to the bedside and back. K12 Scholars engage in a multidisciplinary curriculum with didactic, laboratory, and clinical experience components in basic, translational, and clinical research in cancer- related fields. Scholars are guaranteed protected time for mentored translational research, and each is mentored by a clinician-scientist and a laboratory researcher.

PI_NAMEs: MORTIMER, JOANNE E. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Administrator;Advisory Committees;anti-cancer research;Award;Cancer Biology;career development;Cities;City of Hope Comprehensive Cancer Center;Clinical;Clinical Investigator;Clinical Oncology;Clinical Oncology Supplement (K12);Critiques;Data;Diagnosis;Disease;Educational Curriculum;Eligibility Determination;Enrollment;Ensure;Faculty;Foundations;Funding;Generations;Goals;Good Clinical Practice;Grant;improved;Individual;interdisciplinary approach;K-Series Research Career Programs;Laboratories;Leadership;Malignant - descriptor;medical specialties;member;Mentored Clinical Scientist Development Program;Mentors;mid-career faculty;novel strategies;Prevention;Principal Investigator;Process;Productivity;professor;programs;Protocols documentation;Publications;Research;Research Design;Research Personnel;Research Project Grants;responsible research conduct;skills training;statistics;Structure;success;Suggestion;Time;Training;Training Programs;Translating;Translational Research;United States National Institutes of Health;Writing

PROJECT_TITLE: City of Hope Clinical Oncology Career Research Development Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Uveal melanoma (UM) is the most common eye malignancy with high mortality once it metastasizes to the liver. No effective treatments exist for metastatic patients. Our proposed studies aim to identify new therapeutic strategies, and validate them using clinically relevant in vivo disease models with the overall goal to develop new treatment approach for UM patients.

PI_NAMEs: CHEN, XU  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Automobile Driving;BRAF gene;Buffers;Cardiolipins;Cell Proliferation;Cell Survival;Cells;Clinical;clinical efficacy;clinically relevant;Combined Modality Therapy;Coupled;CRISPR/Cas technology;Data;Dependence;Development;Diglycerides;Disease;disease model;effective therapy;Endothelin;Endothelin-1;Engineering;Environment;Enzymes;experimental study;Exposure to;Eye;Family member;Feedback;G-Protein-Coupled Receptors;Gene Mutation;Genes;Genetic Engineering;genome-wide;GNAQ gene;Goals;immune checkpoint blockade;Immune checkpoint inhibitor;improved;In Vitro;in vivo;inhibitor;Knock-in Mouse;Knock-out;Knockout Mice;Ligands;Lipid Synthesis Pathway;Lipids;Liver;loss of function;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Neoplasm to the Liver;Metastatic to;Methods;Mitogen-Activated Protein Kinases;mortality;mouse model;Mutation;Nature;Neoplasm Metastasis;new therapeutic target;NF1 gene;novel;novel therapeutic intervention;Oncogenic;overexpression;Pathway interactions;Patients;Phenotype;phosphatidate;phosphatidylcholine-specific phospholipase C;Phosphatidylinositols;Phospholipase C;phosphoproteomics;Phosphorylation;Protein Kinase C;Protein Kinase C Inhibitor;receptor;Regimen;Regulation;Resistance;resistance mechanism;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Somatic Mutation;subcutaneous;success;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;transcriptional reprogramming;transcriptome sequencing;Treatment Efficacy;tumor;United States;Up-Regulation;Uveal Melanoma;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Gq pathway in uveal melanoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN SOCIETY OF NEPHROLOGY, INC.

ORG_STATE: DC

PHR: NARRATIVE Dialysis access is the Lifeline for dialysis but is unfortunately characterized by significant inequities and disparities in care. We plan to address this problem by recruiting, training (both in dialysis access and professional career development) and mentoring, a group of minority and under-represented in medicine, senior fellows/early career faculty, who will then work within ASN, and their own professional career pathways to address this issue.

PI_NAMEs: IBRAHIM, TOD RAMSES (contact);ROY-CHAUDHURY, PRABIR

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Advisory Committees;American;Area;Black race;Blood Vessels;candidate identification;career;Career Choice;career development;Caring;Child;Clinic;Clinical;cohort;Communities;course development;Development;Dialysis procedure;Discipline;early-career faculty;Ecosystem;Ensure;Entrepreneurship;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Exposure to;Feedback;Fostering;Future;Gender;Geography;Goals;Grant;Health;health care disparity;Health Professional;Health Services Accessibility;Healthcare;Hispanic;improved;Indigenous;Individual;Inequity;innovation;Justice;Kidney;Kidney Diseases;Leadership;leadership development;Life;Link;Medicine;meetings;member;Mentors;Mentorship;Minority Groups;Native Hawaiian or Other Pacific Islander;Nephrology;Nurses;Outcome;Participant;Pathway interactions;patient oriented;Patients;peer;peer coaching;Peritoneal Dialysis;Persons;Pharmacists;Physicians;Policies;Population;posters;Prevalence;Process;programs;Race;recruit;Research;response;skill acquisition;skills training;Societies;symposium;synergism;Training;training opportunity;Training Programs;United States;virtual;Work;Workforce Development;Writing

PROJECT_TITLE: Dialysis Access Justice, Equity, Diversity, Inclusion (DA-JEDI) Program.


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: EMADI, ASHKAN  (contact)

PROJECT_TERMS: acronyms;Architecture;Asian population;Baltimore;biobank;Biometry;Cancer Center Support Grant;cancer clinical trial;cancer therapy;Catchment Area;Clinical Data;clinical implementation;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;college;Comprehensive Cancer Center;cost;cost effective;Data;Data Collection;data management;data quality;data quality/integrity;Databases;Dedications;Disease;Doctor of Medicine;Doctor of Philosophy;Enrollment;Ensure;Equipment and supply inventories;Flow Cytometry;Focus Groups;Fostering;Funding;Genomics;Grant;health disparity;health equity promotion;hormone related cancer;Human;human old age (65+);Human Resources;Image;improved;Individual;Industry;Information Technology;innovation;Institution;Intervention;Intervention Trial;Investigational Therapies;investigator-initiated trial;Laboratories;Leadership;life span;Malignant Neoplasms;Maryland;Measures;Medical;Medical center;medical schools;member;minimal risk;Minority;Mission;Modality;Molecular Biology;Monitor;National Cancer Institute;neoplasm immunotherapy;Nurses;Office Management;Oncology;oncology trial;operation;participant enrollment;Pathology;patient oriented;patient safety;Patients;pediatric patients;Peer Review;Persons;Phase;phase I trial;phase II trial;Play;Population Sciences;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Reporting;Research;Research Activity;Research Personnel;Safety;Services;Site;structural biology;System;Therapeutic Trials;trial enrollment;tumor immunology;Underrepresented Minority;Universities;virology;Wages;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Childhood Obesity;Congenital Structural Anomalies;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Snord116 is a small nucleolar RNA that is genetically linked to appetite control. In this project, I will determine the molecular function of Snord116 in appetite-regulating centers of the brain and investigate how Snord116 loss affects the activity of neurons in these regions. Doing so is expected to contribute novel insights to the molecular basis of appetite control in the brain.

PI_NAMEs: WHILDEN, COURTNEY MICHELLE (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adult;Affect;Appetite Stimulants;Base Pairing;Binding Sites;Biogenesis;Biological Assay;Biology;Brain;Brain region;Cell Nucleus;Cell Physiology;Child;Childhood;computer studies;crosslink;Data;Defect;Desire for food;Eating;Electrophysiology (science);Exhibits;Failure to Thrive;Fasting;feeding;Feeding behaviors;Functional disorder;Future;Genetic;Goals;Health;Hyperphagia;Hypothalamic structure;Immunohistochemistry;Immunoprecipitation;Impairment;Individual;infancy;insight;interest;laboratory experiment;Link;Mediating;Messenger RNA;microdeletion;Molecular;Molecular Target;Mus;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;Northern Blotting;novel;novel therapeutics;Obesity;Physiology;Play;polysome profiling;Population;postnatal;Prader-Willi Syndrome;Property;Protein Biosynthesis;Proteins;Regulation;Ribosomal RNA;ribosome profiling;Ribosomes;RNA Processing;Role;Satiation;Site;Slice;Small Nucleolar RNA;Structure of nucleus infundibularis hypothalami;Testing;Tissues;Translations;Untranslated RNA;Viral;Work

PROJECT_TITLE: Non-coding RNA regulation of neuronal protein translation and appetite control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Intentionally incorporating professional skills development into biomedical research training is essential to national goals of developing a diverse and adaptable scientific workforce, but advances in training have been limited by a lack of central mechanisms and incentives to share effective practices, leading to inefficiencies where institutions “recreate the wheel” or leave trainees without evidence-based professional skills training at their institutions. This project will support dissemination of effective educational approaches, provide training and mentoring for faculty and staff to implement those models, and develop assessment protocols and training. By training and mentoring faculty to enhance professional skills training at their institutions, we will impact research trainees across the country, enhancing training to meet the nation's workforce needs.

PI_NAMEs: FUHRMANN, CYNTHIA N (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Adoption;Area;Back;Benchmarking;Biomedical Research;career;cohort;Collection;Communication;Communities;Competence;Country;Data;Development;diversity and inclusion;Education;education evaluation;Educational Curriculum;Educational Models;Educational process of instructing;Educational workshop;empowerment;Equity;Evaluation;evidence base;Evidence based practice;Evolution;Faculty;faculty mentor;faculty support;feeding;Goals;Graduate Education;Grant;higher education;Home;implementation strategy;Incentives;Individual;Infrastructure;innovation;Institution;Intervention;Leadership;Literature;mentoring community;Mentors;Mentorship;model building;Modeling;National Institute of General Medical Sciences;outreach;Participant;Peer Review;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Protocols documentation;Publishing;Reproducibility;Research;Research Training;role model;Scientific Societies;skill acquisition;skills;skills training;Source;Specialist;Students;sustainability framework;Testing;Time;tool;Trainers Training;Training;Travel;Work;workforce needs;Writing

PROJECT_TITLE: Catalyzing the Spread of Evidence-Based Practices in Biomedical Research Training


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Meiotic errors are remarkably common in oocytes and give rise of chromosomal abnormalities in eggs and embryos, a leading cause of miscarriages, infertility, and genetic disorders. Spindle-bound actin filaments have recently emerged as a new mechanism that safeguards the accuracy of oocyte meiosis. The goal of this research to obtain molecular understanding of spindle actin filament assembly and function at the chromosome-microtubule interface in mammalian oocytes and embryos.

PI_NAMEs: MOGESSIE, BINYAM  (contact)

PROJECT_TITLE: Actin-based mechanisms of chromosome segregation in mammalian oocytes and embryos

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: ROBERTS, TIMOTHY P (contact)

PROJECT_TERMS: 3 year old;6 year old;Acceleration;Activities of Daily Living;Adopted;Affect;age acceleration;Age Years;aged;Auditory;Auditory area;Auditory Evoked Potentials;autistic children;Behavior;Biological Markers;Brain;Brain region;Caregivers;Child;Clinical;Clinical assessments;clinical diagnosis;Cognitive;cognitive ability;cohort;Communication;design;Detection;Development;Diagnosis;Down's Syndrome;Electrophysiology (science);Enrollment;Event;follow-up;functional outcomes;functional status;Future;Gene Mutation;genetic disorder diagnosis;Genetic Risk;genomic profiling;Goals;Impairment;improved;Individual;Infant;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention;Laboratories;Language;Language Development;lexical;longitudinal design;Magnetoencephalography;Measures;minimally verbal;Nature;neural;neural correlate;non-verbal;Nursery Schools;Outcome;Outcome Assessment;outcome prediction;Parents;Phase;predictive marker;Predictive Value;Procedures;Process;Prospective cohort;recruit;Reporting;Research;Research Design;Research Project Grants;Resolution;Response Latencies;Risk;risk stratification;Scanning;Schedule;School-Age Population;Services;Severities;Source;specific language impairment;Specific qualifier value;Specificity;Standardization;Stimulus;success;Syndrome;Time;Toddler

PROJECT_TITLE: Early Predictors of Cognitive/Language Development


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

PHR: NARRATIVE The acquisition of detailed molecular and spatial data on human tumors using highly multiplexed microscopy promises to improve fundamentally our understanding of cancer initiation and progression, particularly the critical role played by interactions between tumors the immune system. Advancing the state of the art in tissue imaging is also likely to impact digital pathology in the clinic, leading to better diagnosis and disease management.

PI_NAMEs: LIN, JIA-REN  (contact)

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: Aftercare;Area;Atlases;Cancer Biology;Cancer Center;cancer imaging;cancer initiation;Cell Communication;cell type;Cells;Clinic;Clinical Trials;Collaborations;Collection;Core Biopsy;Data;design;Diagnosis;digital pathology;Disease;Disease Management;Doctor of Philosophy;Environment;Fine needle aspiration biopsy;Formaldehyde;Funding;Goals;high dimensionality;high resolution imaging;Human;Image;Immune system;Immunofluorescence Immunologic;immunological synapse;improved;insight;invention;Journals;Laboratories;Lead;Licensing;mass spectrometric imaging;Methods;Microscopy;Molecular;Morphology;Mus;novel strategies;Paraffin Embedding;Patients;performance site;Periodicity;Pharmacology;Play;protein biomarkers;Protocols documentation;Public Domains;Publications;Publishing;Research;research and development;Research Support;Resolution;Role;Slide;Solid Neoplasm;Specialist;Specimen;Staging;Structure;System;Technology;technology development;Three-Dimensional Imaging;Tissue imaging;Tissue Preservation;Tissues;Transcript;treatment response;tumor;tumor progression;Work

PROJECT_TITLE: Advancing technologies for the collection and analysis of high dimensional immunoprofiles and tumor images


ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative How gene expression is regulated can inform the development of complex biological systems and help design treatment strategies for diseases by manipulating cell states; however, to accurately infer gene regulatory net- works, we urgently need to develop robust computational methods that incorporate rich transcriptomics and epigenomics data measured in single cells. This research program will develop computational methods for in- ferring and analyzing gene regulatory networks using multi-sample single-cell multiomics and spatial genomics data, use spatial trajectories from spatial transcriptomics data to characterize spatio-temporal gene regulation, and build network control strategies to manipulate networks to desired states (such as cellular healthy states). This research is expected to signiﬁcantly reduce the wasted resources in downstream validation experiments and reduce the cost in disease treatment.

PI_NAMEs: HOU, WENPIN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Biological Process;Categories;Cell Communication;cell type;Cells;Communities;complex biological systems;Computer software;Computing Methodologies;cost;Data;Development;Disease;epigenomics;experience;experimental study;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;genomic data;Goals;Heterogeneity;Knowledge;Measures;method development;Methods;multimodality;Multiomic Data;multiple omics;novel;open source;Population;Process;programs;Regulation;Regulatory Element;Research;Resources;Sampling;Series;single cell genomics;spatiotemporal;Statistical Methods;Technology;therapy design;Time;Tissues;transcriptomics;treatment strategy;Validation;wasting;Work

PROJECT_TITLE: Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: DUONG, VU H. (contact)

PROJECT_TERMS: acronyms;Address;Adult;Adverse event;anti-cancer research;Award;Baltimore;biobank;biological specimen archives;Biological Specimen Banks;Biometry;Calendar;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer prevention;Cancer Therapy Evaluation Program;Categories;Childhood;Clinical;Clinical Cancer Center;Clinical Management;Clinical Research;Clinical Trials;Clinical Trials Design;Collection;college;Committee Members;Communication;Comprehensive Cancer Center;Consent;cost;Data;Dedications;Diagnosis;Disease;Doctor of Medicine;Enrollment;Ensure;expedited review;Faculty;Flow Cytometry;Focus Groups;Funding;Genomics;Goals;Grant;Group Meetings;Guidelines;hormone related cancer;Human;human subject;Image;improved;Industry;Institution;Institutional Review Boards;Intervention;Interview;Investigational Therapies;Laboratories;Letters;Malignant Neoplasms;Maryland;Medical;medical schools;meetings;member;Methodology;minimal risk;Minor;Modality;Modification;Molecular Biology;Monitor;National Cancer Institute;Nature;neoplasm immunotherapy;Office Management;Pathology;Pattern;pediatric department;Peer Review;Phase;Population Sciences;post-market;pre-clinical;Principal Investigator;Procedures;Process;programs;Protocols documentation;quality assurance;Radiation Oncology;Reporting;Research;Research Personnel;Resources;Review Committee;Safety;Sample Size;Services;structural biology;Surveys;System;Technology;tumor immunology;Universities;virology;Writing;young adult

PROJECT_TITLE: Protocol Review and Monitoring System


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative There is a need for developing small molecule tools that can both control protein function and be used for imaging in intact animals or patients. Our approach is to genetically alter cells to produce proteins of interest, such as chimeric antigen receptors (CARs), fused to a small bacterial enzyme called E. coli dihydrofolate reductase (eDHFR). eDHFR binds very tightly to the clinically-used antibiotic trimethoprim (TMP) and eDHFR-expressing cells will take up and bind TMP. We have engineered two derivatives of TMP. The first is coupled to a radioactive isotope that allows quantitative imaging of eDHFR and eDHFR expressing cells in animals using positron- emission tomography. The second is the focus of this research project, a version of TMP that is tethered to another small molecule, pomalidomide (POM). These TMP-POM molecules guide eDHFR-fusion proteins to the protein degradation machinery (e.g. the proteosome) of the cell causing destruction of the fusion protein. We will apply these molecules to show their ability to regulate the expression of diverse fusion partner proteins, to show their mechanism of action, and to improve the therapeutic window of CAR T-cells. This project sets a new precedent for small protein tags which confer dual in vivo imaging and regulation capabilities.

PI_NAMEs: SELLMYER, MARK A (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adopted;Affect;Affinity;Amides;Animals;Antibiotics;Antigens;Benchmarking;Binding;Binding Proteins;Biodistribution;Biological Assay;Biological Models;Bone Marrow;Cancer Model;CAR T cell therapy;cell killing;Cell Physiology;Cell surface;Cells;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;Companions;Coupled;Coupling;Cytokine Receptors;Cytolysis;Cytoplasm;Degradation Pathway;Development;Dihydrofolate Reductase;Dose;Drug Kinetics;Drug Targeting;Engineering;Enzymes;Escherichia coli;Experimental Models;experimental study;fibroblast-activating factor;Flow Cytometry;Fluorescence;fluorescence imaging;Future;Half-Life;Human;human imaging;Ikaros protein;Image;imaging probe;Imides;immune function;immunoregulation;improved;In Situ;In Vitro;in vivo;in vivo imaging;inhibitor;interest;intraperitoneal;knock-down;Lead;Length;Ligands;Link;Luciferases;Malignant neoplasm of ovary;Measures;Mediating;Membrane;Membrane Proteins;Metabolism;Microscopy;Monitor;multicatalytic endopeptidase complex;Multimodal Imaging;Optical reporter;Organism;Patients;Pharmaceutical Preparations;pomalidomide;Positron-Emission Tomography;Process;Property;Protac;protein degradation;protein expression;protein function;protein protein interaction;Proteins;prototype;quantitative imaging;Radioisotopes;radiotracer;Regulation;Research Personnel;Research Project Grants;Rodent;Rodent Model;RUNX1 gene;Science;Serum;Signal Transduction;small molecule;Solid Neoplasm;System;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;trafficking;transcription factor;Translations;Trimethoprim;tumor;ubiquitin-protein ligase;Validation;Western Blotting

PROJECT_TITLE: Regulation of eDHFR-tagged proteins with trimethoprim PROTACs

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative Antibiotics severely alter the gut microbiome producing a state of microbial imbalance called dysbiosis. How dysbiosis affects cancer progression is largely unknown. This project will expand our understanding of the crosstalk between the gut microbiome, the tumor microenvironment, and cellular immunotherapy during antibiotic-induced dysbiosis.

PI_NAMEs: DINGS, RUUD P.M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acceleration;Affect;Ampicillin;Antibiotic Therapy;Antibiotics;Blood Vessels;Cancer Patient;Cell Adhesion Molecules;Cellular immunotherapy;chimeric antigen receptor T cells;Ciprofloxacin;Clinic;Clinical;combat;commensal bacteria;Congenic Mice;Data;Defect;Development;Distal;Dorsal;dysbiosis;Effectiveness;effector T cell;Endothelial Cells;Endothelium;Extravasation;fecal transplantation;fighting;Flow Cytometry;Fluorescence Microscopy;Foundations;Frequencies;Future;Gastrointestinal tract structure;Goals;gut microbiome;gut microbiota;Homeostasis;Human;Image;Immune;Immune checkpoint inhibitor;Immune system;immunogenic;Immunosuppression;Immunotherapy;improved;Incidence;Infection;Intercellular adhesion molecule 1;intravital microscopy;Investigational Therapies;Knowledge;Leukocyte Trafficking;Leukocytes;Malignant Neoplasms;MEL Gene;Melanoma;Metronidazole;microbiome;Modeling;Molecular;Morbidity - disease rate;Mus;Neomycin;Nude Mice;optoacoustic tomography;pathogenic bacteria;Patients;Publishing;response;rRNA Genes;Solid Neoplasm;success;Supplementation;T cell infiltration;T cell therapy;T-Lymphocyte;Therapeutic;therapy development;Time;TNF gene;trafficking;transcriptome sequencing;Treatment Efficacy;Trimethoprim-Sulfamethoxazole;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppression;unpublished works;Vancomycin;Work

PROJECT_TITLE: Improvement of cellular immunotherapy during dysbiosis- Resubmission

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE People with similar degrees of sensorineural hearing loss, as defined by the audiogram, often have varying levels of difficulty understanding speech in noisy environments. To assess the relationship between dysfunction in the auditory periphery and perception, the proposed project uses coordinated non-invasive biomarkers sensitive to multiple sites of cochlear dysfunction in both humans and chinchillas with sensorineural hearing loss to estimate profiles of peripheral pathology and predict hearing outcomes in background noise. Results from this cross- species study will provide valuable insight into the dysfunctions that underlie common auditory complaints and improve personalization of treatments for sensorineural hearing loss.

PI_NAMEs: HAUSER, SAMANTHA NICOLE (contact)

PROJECT_TERMS: Acoustic Nerve;Address;Affect;Age;American;Anatomy;Animal Model;Animals;Atrophic;Audiology;Auditory;Auditory Brainstem Responses;Auditory Threshold;Autopsy;Biological Assay;Biological Markers;career;Caring;Categories;Chinchilla (genus);Clinic;Clinical;clinical training;Cochlea;Cochlear Nerve;cochlear synaptopathy;Communication;Complex;Complex Mixtures;Data;Data Set;design;Development;Diagnostic;diagnostic signature;Diagnostic tests;diagnostic tool;ear muscle;Economics;Environment;Foundations;Functional disorder;Gentamicins;Goals;Health;Healthcare;Hearing;hearing impairment;hearing loss treatment;Hearing Tests;Histologic;Histology;Human;human data;improved;Individual;Individual Differences;Infrastructure;Inner Hair Cells;insight;Intervention;Link;Measures;middle ear;minimally invasive;Modeling;Nerve Degeneration;neural;Noise;noise exposure;noise perception;noninvasive diagnosis;normal hearing;Outcome;Outer Hair Cells;Pathology;Perception;Performance;Peripheral;personalized diagnostics;personalized medicine;Persons;Pharmacologic Substance;Physiological;Population;pre-clinical;predictive modeling;Recording of previous events;Reflex action;Reporting;Research;response;Risk Factors;Sampling;Sensorineural Hearing Loss;Site;social;Societies;sound;Speech;speech in noise;Speech Perception;Stria Vascularis;synergism;Temporal bone structure;Testing;Training;Translations;Work

PROJECT_TITLE: Individualized Profiles of Sensorineural Hearing Loss from Non-Invasive Biomarkers of Peripheral Pathology


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Alcohol use disorder (AUD) and its outcomes are a leading cause of death and disability in the United States, but the neurobiological changes underlying the pathogenesis of AUD are unknown. This proposal aims to investigate the long non-coding RNA Gas5 as a regulator of glucocorticoid-dependent molecular and behavioral phenotypes of alcohol dependence. This research will uncover a novel facet of AUD neurobiology that may lead to more effective therapeutics for AUD and other human conditions.

PI_NAMEs: RICE, RACHEL  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;Adult;Adult women;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Anhedonia;Animals;Anxiety;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Bilateral;biobehavior;Biological;Biological Assay;Brain Diseases;Brain region;Cause of Death;Cell Physiology;Chronic;chronic alcohol ingestion;Chronic stress;Code;Cohort Studies;comorbidity;Consumption;Convulsions;CRISPR/Cas technology;Data;Dependence;Dependovirus;Development;diagnostic criteria;disability;Disease;economic cost;Ethanol;Ethanol dependence;Feedback;Female;Gene Expression;Genes;Genetic Transcription;Genome;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Goals;Growth;Guide RNA;Human;human disease;hypothalamic-pituitary-adrenal axis;Immunoprecipitation;Impairment;Injections;knock-down;Laboratories;Link;Literature;male;Medial;Mediating;Mediator;Mentors;Messenger RNA;Modeling;Molecular;molecular phenotype;Mus;negative affect;Neurobiology;neuronal growth;Neurons;next generation;novel;Outcome;Pathogenesis;Pharmacotherapy;Phenotype;Physiology;Play;preference;Prefrontal Cortex;Proteins;Public Health;rational design;receptor binding;receptor function;Receptor Signaling;Relapse;Research;Research Training;response;Response Elements;RNA;Rodent;Role;Scientist;sex;Signal Transduction;skills;socioeconomics;Sorting;stressor;Sucrose;System;Testing;therapeutically effective;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;United States;Untranslated RNA;vapor;vector;Withdrawal

PROJECT_TITLE: The role of lncRNA Gas5 in Glucocorticoid-Mediated Ethanol Dependence Phenotypes


NIH_SPENDING_CATS: Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: BENTZEN, SOREN M (contact)

PROJECT_TERMS: acronyms;analytical method;anti-cancer research;Artificial Intelligence;Basic Science;Big Data;biobank;Bioinformatics;biomarker discovery;Biomedical Research;Biometry;Biostatistics Core;cancer cell;Cancer Center;Cancer Research Project;Clinical;Clinical Cancer Center;Clinical Oncology;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;college;Comprehensive Cancer Center;Computing Methodologies;Consultations;Data;Data Analyses;Data Analytics;Data Collection;data mining;Data Set;Data Sources;Databases;Doctor of Philosophy;education resources;Educational process of instructing;Educational workshop;Environment;Epidemiology;experience;Extramural Activities;Faculty;faculty support;Familiarity;Flow Cytometry;Fostering;Foundations;Funding;gene regulatory network;Genomics;Grant;Health Sciences;high dimensionality;hormone related cancer;Human;Image;innovation;Interdisciplinary Study;Investigational Therapies;Investigator-Initiated Research;Journals;Knowledge;Laboratories;Link;Machine Learning;Malignant Neoplasms;Maryland;mathematical methods;Medical;medical schools;Medicare;Medicine;member;Mentors;Methodology;Methods;Mission;Molecular Biology;Nature;NCI Center for Cancer Research;neoplasm immunotherapy;Oncology;Outcome Study;Pathology;Peer Review;peer support;personalized medicine;Pilot Projects;Population;population health;Population Research;Population Sciences;pre-clinical;pre-clinical research;programs;Protocols documentation;Public Health;Publications;Publishing;Registries;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Science;Scientist;service member;Services;skills;Statistical Methods;structural biology;Students;System;Systems Biology;Terminology;The Cancer Genome Atlas;Time;Training;training opportunity;Translational Research;tumor immunology;Universities;Wages

PROJECT_TITLE: Biostatistics Shared Service


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PI_NAMEs: D'AMORE, PATRICIA ANN (contact)

PROJECT_TITLE: Core Grant For Vision Research-Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative We propose to establish a Hemophilia A Analytical Cohort Research Program (HARP) to support the development of an Intergenerational Precision Medicine Program for the study of factor VIII (FVIII) immunogenicity in severe hemophilia A. The three major aims of HARP are to form a new longitudinal antenatal/neonatal/pediatric severe hemophilia A cohort to study the development of FVIII inhibitors, to enable the development of the HARP Shareable Resource comprised of well annotated data and biological samples, and to perform hypothesis-testing research in each of the four scientific emphasis areas. The HARP data and biospecimen resources collected over the course of the program will advance our knowledge of the pathophysiology of inhibitor development and be accessible to community researchers through a portal, F8portal.org.

PI_NAMEs: JOHNSEN, JILL MARIE (contact);MEEKS, SHANNON L.;PAGE, GRIER P

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Address;Alleles;antenatal;Antibodies;Antibody Affinity;Area;B-Lymphocytes;biobank;Biological;Biological Assay;Biometry;Cells;Child;Childhood;Clinical;clinical center;Clinical Data;Clonal Expansion;cohort;commune;Communication;Communities;Community Networks;computing resources;Consensus;Coupled;Data;Data Analyses;Data Analytics;Data Collection;data harmonization;Data Set;data sharing;design;Development;Enrollment;Environment;Environmental Risk Factor;Epitope Mapping;Epitopes;Evaluation;Event;Exposure to;F8 gene;Factor VIII;falls;fetal;flexibility;Functional disorder;Future;gene product;Genes;Genetic;Genetic Carriers;genetic counselor;Genotype;Hemophilia A;Hemorrhage;IgG1;Immune;Immune response;Immune system;immunogenicity;Immunologics;Immunology;implementation barriers;Infant;Inflammatory;Inherited;inhibitor;innovation;intergenerational;Investigation;Kinetics;Knowledge;Life;Link;Methods;Microchimerism;Monitor;Mothers;multiple omics;Neonatal;neonate;offspring;Outcome;participant safety;Patients;Peptides;Perinatal;Perinatal Exposure;Phenotype;pilot test;precision medicine;Production;Productivity;Program Accessibility;programs;Proteins;Protocols documentation;recruit;repository;Research;Research Personnel;Research Support;Resources;Risk;sample collection;Sampling;Specimen;Statistical Methods;System;Testing;Time;trial design;Umbilical Cord Blood;Variant;Work

PROJECT_TITLE: A Severe Hemophilia A Intergenerational Cohort Research Program for the Study of Factor VIII Immunogenicity


PI_NAMEs: CHAUHAN, SUNIL K (contact)

PROJECT_TERMS: Biological Markers;Calibration;Cell Count;Cell Separation;Cells;Core Grant;Data;Data Analyses;Databases;Detection;Equipment;Flow Cytometry;Fluorescence;Individual;Internet;Lasers;Maintenance;monolayer;Phenotype;Population;Principal Investigator;Procedures;Research Personnel;Scanning;Services;Sorting;Speed;Tissues;Vision research

PROJECT_TITLE: Core Grant for Vision Research-Flow Cytometry Core


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Anesthesia procedures;Animal Experimentation;Animal Experiments;animal imaging;Animal Model;animal resource;Animals;Blindness;Breeding;Consult;Core Grant;Development;disorder prevention;Equipment;Eye diseases;Fundus photography;Genotype;Goals;Image;Laboratory Animal Models;Maintenance;Microscope;Mission;mouse model;mutant mouse model;novel;Operative Surgical Procedures;Pathogenesis;Pharmaceutical Preparations;Phenotype;Postoperative Care;programs;Protocols documentation;Research;research faculty;research study;Resource Sharing;Rodent;Services;System;Techniques;Testing;Training;Transgenic Organisms;Vision research;Visual;visual dysfunction

PROJECT_TITLE: Core Grant for Vision Research-Animal Module Core


PI_NAMEs: ARGUESO, PABLO  (contact)

PROJECT_TERMS: Computers;Confocal Microscopy;Consultations;Core Grant;cryostat;digital imaging;Electron Microscopy;epon;Equipment;Fluorescence;Frozen Sections;Histology;Housing;Lasers;light microscopy;Methacrylates;Microdissection;Microscope;Microscopy;Morphology;Paraffin;Phase;Procedures;Process;Resources;Scanning Electron Microscopy;Services;System;Tissues;Training;Transmission Electron Microscopy;Vision research

PROJECT_TITLE: Core Grant for Vision Research-Morphology Module Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ELZE, TOBIAS  (contact)

PROJECT_TERMS: animal resource;Automobile Driving;clinical examination;Code;Computer software;Computer Systems;computerized;Computers;Core Grant;Data;Data Analyses;data exchange;Equipment;Flow Cytometry;Image;Individual;Laboratories;Laboratory Research;machine learning algorithm;Microcomputers;Morphology;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Services;software infrastructure;System;Time;Training;Update;Vision research

PROJECT_TITLE: Core Grant for Vision Research-LABORATORY COMPUTER APPLICATIONS MODULE (LCAM)


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PI_NAMEs: HEATH, JAMES R. (contact)

PROJECT_TERMS: Acceleration;Accountability;Advocate;Awareness;biobank;Biological;Cancer Biology;Clinic;Clinical;Clinical Oncology;collaborative environment;Combination immunotherapy;Combined Modality Therapy;Communication;Communities;Cutaneous Melanoma;Data;design;Education and Outreach;Educational Materials;Educational process of instructing;Engineering;Environment;Evaluation;Faculty;Feedback;flexibility;Funding;Goals;Immunotherapy;Infrastructure;inhibitor;Institution;Intellectual Property;Learning;Logistics;Malignant Neoplasms;meetings;Mentors;Monitor;mouse model;multiple omics;outreach program;Patients;Persons;Pilot Projects;Process;Program Description;programs;Protocols documentation;Reagent;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Schedule;Scientist;Self-Examination;Series;Solid Neoplasm;spatiotemporal;Specimen;STEM field;Structure;Students;Systems Biology;Talents;targeted treatment;teacher;Thinking;Tissues;tool;Training Support;translational goal;translational potential;Translations;tumor;Underrepresented Minority;Underrepresented Populations

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This proposal aims to first confirm statins protective effects on the radiographic knee (OA) progression in a subset of Osteoarthritis Initiative (OAI) participants with non-traumatic generalized osteoarthritis (OA) with Heberden's nodes (i.e., HN+ GOA) and no/minimal subchondral bone marrow lesions (BMLs), as the “potential responders” using advanced MRI measures of cartilage structural damage and serum/urine cartilage degradation biomarkers. Second, the mediatory role of subchondral bone morphometry and subchondral BMLs will be assessed for the protective effect statin on radiographic knee OA outcome. We will further explore subchondral bone and vascular structures and analyze the osteogenesis, angiogenesis, and accumulation of senescent cells (SnCs) in subchondral bone in early dyslipidemia-associated non-traumatic OA mice models to evaluate the mechanism underlying the therapeutic effect of statins.

PI_NAMEs: DEMEHRI, SHADPOUR  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;angiogenesis;Animal Experiments;Apolipoprotein E;Area;articular cartilage;Atherosclerosis;Biological Markers;Blood Vessels;Body Weight;Bone Infarction;Bone Marrow;C-terminal;Cardiovascular Diseases;Cartilage;cartilage degradation;Clinical;clinical examination;clinical practice;Clinical Trials;cohort;Collagen;Consensus;Data;Defect;Degenerative polyarthritis;design;Disease;Dose;Dyslipidemias;epidemiology study;Etiology;experimental study;follow-up;Genetic Predisposition to Disease;Hand;hazard;Heberden's Node;High Fat Diet;Human;Image;Inbred CBA Mice;indexing;Intake;Investigation;Ischemia;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;Lesion;Link;Lipids;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;Medicare claim;microangiography;Modeling;Morphology;morphometry;mouse model;Mus;novel;Observational Study;Osteogenesis;Outcome;Pain;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Prevalence;protective effect;protein oligomer;Protocols documentation;Publishing;radiological imaging;Resources;Risk;Role;senescent cell;Serum;Structure;subchondral bone;Subjects Selections;Symptoms;Testing;Therapeutic Effect;Time;Uncertainty;urinary;Urine;Western Ontario and McMaster Universities Arthritis Index;Wild Type Mouse

PROJECT_TITLE: Effect of statin intake on Non-traumatic Generalized Knee Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: FAN, XIAOXUAN  (contact)

PROJECT_TERMS: Acceleration;acronyms;anti-cancer research;Antibodies;Area;Baltimore;biobank;Biology;Biometry;Biotechnology;Cancer Biology;Cancer Center;CAR T cell therapy;Cell Separation;Cell Therapy;Cells;Clinical;Clinical Trials;Color;Communication;Compensation;Comprehensive Cancer Center;Consultations;Containment;cost effective;Cytometry;Data;Data Analyses;design;Doctor of Medicine;Doctor of Philosophy;education resources;Equipment;experience;Experimental Designs;extracellular vesicles;Fees;Flow Cytometry;Funding;Generations;Genomics;Grant;high dimensionality;hormone related cancer;Hospitals;Image;Image Cytometry;Immune system;Immunology;Immunophenotyping;innovation;Institution;Instruction;instrument;instrumentation;Investigational Therapies;Journals;Laboratories;lectures;Malignant Neoplasms;Maryland;Measurement;member;Mission;Molecular Biology;Monitor;Nature;neoplasm immunotherapy;Noise;novel;operation;Pathology;Patients;Peer Review;Play;Population;Population Sciences;Production;programs;Protein translocation;Publications;Publishing;Quality Control;Reproducibility;Research Design;Research Personnel;Research Support;Sampling;Services;Sorting;Source;Sterility;Strategic Planning;structural biology;Structure;success;Technology;therapy development;Titrations;Training;training opportunity;tumor immunology;United States National Academy of Sciences;Universities;Washington

PROJECT_TITLE: Flow Cytometry Shared Service


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Immunotherapy;Precision Medicine;Skin Cancer

PROJECT_TERMS: Adoptive Cell Transfers;Aftercare;anti-CTLA4;anti-PD-1;anti-PD-L1;Antigens;Area;biobank;Biopsy;Cancer Histology;Child;Clinical;Clinical Data;clinical development;Clinical Trials;clinically relevant;Clonal Expansion;Combination immunotherapy;combinatorial;Combined Modality Therapy;computational pipelines;Cutaneous Melanoma;Data;Data Analyses;data resource;Data Set;design;Dose;driver mutation;engineered T cells;Engineering;Environment;Formalin;Foundations;Freezing;Goals;Immune;immune checkpoint blockade;Immune system;Immunocompetent;immunogenic cell death;Immunologic Factors;Immunotherapy;immunotherapy trials;improved;in vivo;Inflammatory;inhibitor;inhibitor therapy;insight;Lead;Malignant Neoplasms;MAP Kinase Gene;MEKs;Melanoma;Melanoma patient;Melanoma Tumor;Metastatic malignant neoplasm to brain;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;movie;Multiomic Data;multiple omics;Mus;mutant;Mutation;neoantigens;neoplastic cell;Oncogenes;Outcome;overexpression;Paraffin Embedding;Pathway interactions;Patients;Physiological;posters;prevent;Progression-Free Survivals;rational design;Regimen;Resistance;Resistance development;resistance mechanism;Resolution;Resources;response;Retrospective Studies;Role;Sampling;spatiotemporal;subcutaneous;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy outcome;Therapy trial;Time;Tissues;tool;Treatment Efficacy;treatment response;Triplet Multiple Birth;tumor;Tumor Antigens;Tumor Immunity;Tumor-associated macrophages;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: PROJECT 1: TIME-Based Spatiotemporal Cancer Immunograms Predictive for Immunotherapy-Targeted Therapy Sequential Combinations


ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE - NADPH is implicated in various diseases, including cancer and neurodegenerative disorders. NADK2 deficiency depletes the mitochondrial pool of NADPH and results in severe neurological and developmental symptoms in patients, however the metabolic consequences of NADK2 deficiency are not known. Here we will identify the vital functions of NADK2 and mitochondrial NADPH in cell metabolism, cell growth and proliferation, paving way for future therapeutic interventions for proliferative diseases and for patients with NADK2 mutations.

PI_NAMEs: HOXHAJ, GERTA N/A (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adenine;Affect;Anabolism;Antioxidants;Biochemical;Biology;Biomass;cell growth;Cell Proliferation;Cells;Cellular Metabolic Process;cofactor;combat;Coupled;Cytoprotection;Data;Development;developmental disease;dietary restriction;Disease;Drug Metabolic Detoxication;Energy Supply;enzyme biosynthesis;Enzymes;Exhibits;experimental study;Future;gene synthesis;Glucose;Glutamine;Goals;Growth;Health;Health Benefit;Homeostasis;Human;Human Cell Line;Hypoxanthines;in vivo;Isotopes;Knock-out;Lipids;macromolecule;Maintenance;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measurement;Mediating;Metabolic;Methods;Mitochondria;Molecular;mutant;Mutation;NAD+ kinase;NADP;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurologic Symptoms;novel therapeutic intervention;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patients;Phenotype;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Production;Proliferating;Proline;Protein Biosynthesis;Reactive Oxygen Species;Role;Science;Source;Supplementation;Supporting Cell;Symptoms;Testing;Therapeutic;Therapeutic Intervention;tumor;tumor growth;Withdrawal

PROJECT_TITLE: Revealing the essential functions of mitochondrial NADPH and NADK2 for cell growth and proliferation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Childhood Leukemia;Hematology;Immunotherapy;Orphan Drug;Ovarian Cancer;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Urologic Diseases;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative The aim of the Pediatric and Medical Oncology Career Development Program is to provide physicians with the tools and experience necessary to conduct clinical research, translate their findings to patients, and generate sufficient data to help establish independent research careers. Trainees will contribute new and useful information relevant to clinical oncology.

PI_NAMEs: DAVIDSON, NANCY ELLEN;MESHINCHI, SOHEIL  (contact)

PROJECT_TERMS: Adult;Area;Biology;Biomedical Research;Biometry;Brain Neoplasms;cancer care;career;career development;Childhood;Clinical;clinical application;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Skills;clinical translation;Clinical Trials Design;Data;Evaluation;experience;Fellowship;Fred Hutchinson Cancer Research Center;Funding;gene therapy;Goals;Grooming;Hematology;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Human;Immunogenetics;Immunology;Immunotherapy;K-Series Research Career Programs;Laboratories;Laboratory Finding;Laboratory Research;Malignant - descriptor;Mammary Neoplasms;Medical;Medical Oncology;medical schools;Medicine;Mentored Clinical Scientist Development Program;Modernization;Molecular Biology;next generation;Oncology;Outcome;ovarian neoplasm;Patients;pediatric department;Pediatric Hematology;Pediatric Hospitals;Pediatric Oncology;Physicians;Program Development;programs;Prostatic Neoplasms;protocol development;Qualifying;Quality of life;Research;research facility;Research Institute;Research Personnel;Research Project Grants;Research Support;Solid Neoplasm;tool;Training;Training Programs;Translating;Translational Research;translational scientist;Translations;Transplantation;Universities;Washington

PROJECT_TITLE: Career Development in Pediatric and Medical Oncology


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Skin Cancer

PI_NAMEs: THORSSON, VESTEINN  (contact)

PROJECT_TERMS: Active Learning;Address;Adoptive Cell Transfers;Binding;biobank;Biological;Biological Assay;cancer cell;Cells;Clinical;clinical development;Clinical Trials Design;Collection;combat;Combination immunotherapy;combinatorial;Combined Modality Therapy;cost;Cutaneous Melanoma;Data;Databases;deep learning model;design;Development;Distal;Dose;Elements;Epigenetic Process;experience;extracellular;follow-up;genomic data;Human;Image;Immune;immune checkpoint blockade;Immunologic Factors;Immunotherapy;improved outcome;in silico;inhibitor;Intervention;Intrinsic factor;Knowledge;Lead;Libraries;Lymphocyte;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Maps;Melanoma;Metastatic Melanoma;Methods;model design;Modeling;Modification;Molecular;mouse model;multiple omics;Mus;Nature;Neoplasm Metastasis;Outcome;outcome prediction;Pathway interactions;Patients;Pattern;Phenotype;Play;Prediction of Response to Therapy;predictive modeling;prevent;Primary Neoplasm;Proteomics;Regimen;Resistance;Resistance development;Resources;response;Role;spatiotemporal;Specimen;Stromal Cells;Systems Biology;targeted treatment;Testing;The Cancer Genome Atlas;therapy outcome;Time;Tissues;transcriptomics;Treatment Protocols;treatment response;tumor;tumor-immune system interactions;Uncertainty;Validation;virtual;Work

PROJECT_TITLE: PROJECT 2: Development and Refinement of Predictive Models for Designing Immunotherapy Combination Treatments


PI_NAMEs: GULLAPALLI, RAO P (contact)

PROJECT_TERMS: Acceleration;acronyms;Advisory Services;Animals;anti-cancer research;Baltimore;biobank;Bioluminescence;biomarker discovery;Biomedical Engineering;Biometry;Blood;Blood - brain barrier anatomy;Cancer Center;Cell Nucleus;cellular imaging;Center Core Grants;Cerebrovascular Circulation;Cerebrum;Clinical;clinical investigation;Clinical Oncology;clinical practice;Clinical Research;clinical translation;Clinical Trials;college;Comprehensive Cancer Center;confocal imaging;Consult;Consultations;Data Analyses;Data Collection;design;Development;Discipline of Nuclear Medicine;Doctor of Philosophy;Drug Delivery Systems;Education;Electron Microscopy;Electrons;Equipment;Experimental Designs;experimental study;Faculty;Flow Cytometry;Fluorescence;Focused Ultrasound;Functional Imaging;Funding;Genomics;Grant;Health Services Accessibility;hormone related cancer;Human;human imaging;Image;Image Analysis;image guided;image guided intervention;imaging biomarker;imaging facilities;imaging modality;Imaging technology;Immunoelectron Microscopy;Institution;instrument;Intellectual Property;Interdisciplinary Study;Interventional Ultrasonography;Investigational Therapies;Journals;Knowledge;Laboratories;Liquid substance;live cell imaging;Magnetic Resonance Imaging;Malignant Neoplasms;Maryland;medical schools;Medicine;member;metabolic abnormality assessment;microPET/CT;Mission;Molecular Biology;multidisciplinary;Nature;neoplasm immunotherapy;neurosurgery;New England;novel;novel imaging technology;Nuclear;Oncology;Pathology;Pathway interactions;Peer Review;Population Sciences;Positron-Emission Tomography;pre-clinical;programs;Publications;Publishing;quantitative imaging;Radiology Specialty;Reagent;Research;Research Design;Research Personnel;Resources;Sampling;Scanning Electron Microscopy;Services;Site;Strategic Planning;structural biology;structural imaging;Students;success;Technology;Therapeutic;tissue fixing;tool;Training;Translating;translational pipeline;Translational Research;transmission process;tumor immunology;Universities;whole animal imaging;Work

PROJECT_TITLE: Imaging Shared Service


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: We propose a new, clinically interpretable, personalized, and generalizable disease index, and a web-tool for efficient quantification of national-level association and causal estimation of longitudinal treatment effects for assessing multi-comorbidities (periodontal disease and Type-2 diabetes), factoring in the intersection of sex/gender influences. Longer-term impact on public health is expected to be far-reaching, bridging the gap between epidemiologists, and health practitioners.

PI_NAMEs: BANDYOPADHYAY, DIPANKAR  (contact);PATI, DEBDEEP

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Accounting;Address;Adult;analytical tool;Area;Behavior;bench-to-bedside translation;Biological Markers;Cardiovascular Diseases;care costs;Characteristics;checkup examination;Clinic Visits;Clinical;Clinical Trials;comorbidity;Complex;Computer software;Computerized Medical Record;cost;COVID-19;Data;Data Science;Data Set;Databases;Debridement;Dental Care;Diabetes Mellitus;Disease;Electronic Health Record;Epidemiologist;Epidemiology;Etiology;Evaluation;Evaluation Studies;experience;Female;flexibility;Funding;Future;Gender;Goals;Government;Health;Healthcare;High Prevalence;high risk;immunosuppressed;improved;Incidence;indexing;Intervention;Kidney Diseases;Knowledge;Life Expectancy;Light;Literature;Liver diseases;Maintenance;male;Measures;Methodology;Methods;Modeling;National Health and Nutrition Examination Survey;National Institute of Dental and Craniofacial Research;Non-Insulin-Dependent Diabetes Mellitus;nonlinear regression;novel;Operative Surgical Procedures;Oral;Oral health;Pathogenesis;Patients;Performance;Periodontal Diseases;Periodontal Index;Phase;Policies;Population;population based;Population Sciences;precision medicine;Prognostic Factor;Public Health;Recommendation;Records;Research;Resources;response;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Reduction;Services;sex;Site;Strategic Planning;Subgroup;Surveys;synthetic data;Techniques;Testing;Time;tool;Tooth Loss;Tooth structure;treatment effect;Uncertainty;United States;United States National Institutes of Health;user-friendly;Validation;validation studies;Variant;Visit;web app;web-based tool;women versus men;Women's Health

PROJECT_TITLE: Sex/Gender influences on periodontal disease and diabetes: A population science approach, with software


PI_NAMEs: LUDWIG, CLAUDIA  (contact)

PROJECT_TERMS: academic standard;Address;Administrator;cancer immunotherapy;Collaborations;Combination immunotherapy;Combined Modality Therapy;Communities;Computer Models;Coupled;Creativeness;design;design,build,test;Development;Disease;Diverse Workforce;Education;Education and Outreach;Effectiveness;experience;Feedback;Goals;Immunooncology;Immunotherapy;improved;inhibitor;insight;Institution;Internships;K-12 Education;Learning;Learning Module;Los Angeles;Medicine;Melanoma;Next Generation Science Standards;Occupations;outreach;outreach program;Participant;Policies;Population;Problem Solving;Professional Education;programs;recruit;Research;Research Personnel;Resources;school district;Science, Technology, Engineering and Mathematics Education;Solid Neoplasm;spatiotemporal;STEM field;Students;System;Systems Biology;teacher;teacher community;Teacher Professional Development;Thinking;tumor;Washington;Work

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Mapping of connections, neurons and nuclei in the human brainstem will enable new and highly specific types of analyses of neuroimaging data. In particular, the ability to probe cellular and connectional properties of specific brainstem nuclei may provide significant advances in disorders such as traumatic brain injury, Alzheimer’s disease, and an array of other neurologic conditions. Finally, the 3D-PSOCT we propose to develop is a potentially transformative tool as it allows direct imaging of axonal orientation with micrometer-scale resolution.

PI_NAMEs: FISCHL, BRUCE  (contact);HOF, PATRICK R;WANG, HUI

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: 3-Dimensional;Algorithms;Alzheimer's Disease;Anatomy;Architecture;Atlases;Axon;Brain;Brain Mapping;Brain Stem;Cell Nucleus;cell type;Cells;cohort;Complex;connectome;Data;deep learning;design;Development;Diffusion Magnetic Resonance Imaging;Disease;Enrollment;ex vivo imaging;Exhibits;Fascicle;Fiber;Fluorescence;Fluorescence Microscopy;Goals;histological image;Histological Techniques;Human;human tissue;Image;Imaging technology;Immunohistochemistry;in vivo;Individual;innovation;Label;Light;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Measures;meter;Microscopic;microscopic imaging;Microscopy;Molecular;Morphology;multi-scale atlas;Myelin;Myelin Sheath;neuroimaging;Neurologic;Neurons;Nuclear;Optical Coherence Tomography;Pathway interactions;Pattern;Planet Earth;preservation;programs;Property;Protocols documentation;rapid technique;Resolution;scale up;Secure;Slice;Stains;Structure;System;Techniques;Technology;Text;Thick;Three-dimensional analysis;Tissue Expansion;Tissue imaging;Tissues;tool;tractography;Traumatic Brain Injury;two-photon;ultra high resolution;Validation;Visualization

PROJECT_TITLE: BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate System


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

PI_NAMEs: LO, ROGER S (contact)

PROJECT_TERMS: Adoptive Cell Transfers;anti-CTLA4;anti-PD-1;anti-PD-L1;Antigen Presentation;biobank;Biopsy;CD8-Positive T-Lymphocytes;Cell Line;Child;Clinical;Clinical Data;clinical development;clinical heterogeneity;combat;Combination immunotherapy;combinatorial;Combined Modality Therapy;Cutaneous Melanoma;Data;Data Analyses;Educational process of instructing;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;immunogenic cell death;Immunologic Factors;in vivo;inhibitor;inhibitor therapy;Lead;MAP Kinase Gene;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Mitogen-Activated Protein Kinase Inhibitor;Modeling;mouse model;Mus;Mutation;neoplastic cell;novel;Pathway interactions;Patients;posters;prevent;programmed cell death ligand 1;Protocols documentation;Recurrence;Regimen;Resistance;resistance mechanism;response;Services;spatiotemporal;Standardization;subcutaneous;success;targeted treatment;Testing;Therapeutic;Tissues;Treatment Protocols;Triplet Multiple Birth;tumor;Tumor Immunity;tumor-immune system interactions;Up-Regulation;Validation

PROJECT_TITLE: Core 1: Mouse Model and Tissue Biobank Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: BALTIMORE

PI_NAMEs: IOFFE, OLGA  (contact)

PROJECT_TERMS: acronyms;African American;Aliquot;Anatomy;Archives;Baltimore;Basic Cancer Research;Benign;biobank;Biometry;Blood;Bone Marrow;Cancer Biology;Cancer Center;cancer health disparity;cancer type;Catchment Area;Cigarette;clinical application;Clinical Oncology;Clinical Research;college;Complex;Comprehensive Cancer Center;Confidentiality of Patient Information;Consultations;cost effective;County;Data Analyses;Data Set;Databases;Diagnosis;Diagnostic;digital imaging;Disease;DNA;Doctor of Medicine;Epidemiology;Ethics;Faculty;feasibility research;Flow Cytometry;follow-up;Formalin;Freezing;Funding;Genomics;Goals;Grant;Health Insurance Portability and Accountability Act;Histology;histotechnology;hormone related cancer;Human;human tissue;Image Analysis;Immunotherapy;in vivo;Infrastructure;innovation;Institutional Review Boards;Investigational Therapies;Journal of the National Cancer Institute;Journals;Knowledge;Laboratories;Malignant Neoplasms;Manuscripts;Maryland;Medical;Medical center;medical schools;member;Methods;Mission;Molecular Biology;Mononuclear;neoplasm immunotherapy;Normal tissue morphology;Oncology;Paraffin Embedding;Pathologic;Pathology;pathology imaging;Patients;Peer Review;peripheral blood;Pharmacy Schools;Plasma;Population Sciences;Preparation;Process;programs;Proteomics;protocol development;Public Health Schools;Publications;racial disparity;Research;Research Design;Research Personnel;Research Support;Resources;RNA;Sampling;School Dentistry;Services;Source;Specimen;Strategic Planning;structural biology;surgical service;System;Techniques;tissue archive;Tissue Banks;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Translating;translational cancer research;Translational Research;tumor;tumor immunology;Tumor Tissue;Universities;virology;Xenograft procedure

PROJECT_TITLE: Pathology and Biorepository Shared Service


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FAN, RONG  (contact)

PROJECT_TERMS: Address;Algorithms;Antibodies;ATAC-seq;Bar Codes;biobank;cancer cell;Cell Nucleus;Cells;ChIP-seq;Clinical;Combination immunotherapy;Computer Analysis;Computer software;cost;cost effective;Data;Data Set;data warehouse;digital;DNA;Epigenetic Process;epigenetic profiling;experience;Fluorescence;fluorescence imaging;Fluorescent Antibody Technique;Freezing;Genes;genome-wide;high throughput analysis;human tissue;Image;Image Analysis;image processing;imaging informatics;Immune;Individual;inhibitor;innovation;interest;kinetic model;Kinetics;Label;Location;Maps;meter;Methods;Modeling;mouse model;multiple omics;Names;nano-string;next generation sequencing;operation;Pathologic;Patients;Pattern;Population;preservation;programs;prospective;Proteins;Proteome;Proteomics;Registries;Reporting;Research;Research Personnel;Resolution;Resources;Running;Scientist;Series;Slice;spatiotemporal;Specimen;Stains;System;Systems Biology;Techniques;Technology;technology development;Time;tissue fixing;Tissue imaging;tissue slice preparation;Tissues;tool;Training;Training Programs;Transcript;transcriptome;tumor;Tumor Tissue;Validation

PROJECT_TITLE: Core 2: Tissue Imaging and Profiling Core


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: WEBER, DAVID JOSEPH (contact)

PROJECT_TERMS: acronyms;Address;Advanced Malignant Neoplasm;American;anti-cancer research;Area;Baltimore;bench to bedside;biobank;Biometry;Cancer Biology;Cancer Center;cancer therapy;Cells;Chemicals;collaborative environment;Collection;Comprehensive Cancer Center;Computer Assisted;computer center;Consultations;Cryoelectron Microscopy;Data;Data Analyses;Data Collection;design;detector;Doctor of Philosophy;drug candidate;Drug Design;drug discovery;Enzymes;Faculty;Flow Cytometry;Funding;Genomics;Grant;hormone related cancer;Human Resources;Image;innovation;instrument;instrumentation;Investigational Therapies;Journals;Laboratories;Leadership;Malignant Neoplasms;Maryland;medical schools;member;Methodology;Methods;Microscope;Mission;Molecular;Molecular Biology;Molecular Mechanisms of Action;Molecular Probes;Molecular Structure;neoplasm immunotherapy;Nuclear Magnetic Resonance;Nucleic Acids;Outcome;particle;Pathology;Peer Review;Pharmaceutical Chemistry;Population Sciences;Preparation;Principal Investigator;programs;Proteins;Publications;Research;Research Design;Research Personnel;research study;Resolution;Robotics;Roentgen Rays;Sampling;Science;screening;Services;Societies;Source;Strategic Planning;Structural Biologist;structural biology;Structure;success;Synchrotrons;Technology;Therapeutic;Training;tumor immunology;Universities;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Shared Service


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Sleep Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: HALLMAYER, JOACHIM F (contact)

PROJECT_TERMS: Advisory Committees;autism spectrum disorder;Biology;Brain;Budgets;career development;Clinical assessments;Communication;conflict resolution;Data;Data Analyses;data management;data sharing;Dedications;Endowment;Ensure;Expenditure;Feedback;Funding;Goals;graduate student;Grant;Human Genetics;Immunology;Individual;innovation;Institutional Review Boards;Intervention;Knock-out;Laboratories;Maintenance;Medical Students;meetings;model of autism spectrum disorder;mouse model;multidisciplinary;Nature;Neurosciences;Occupational activity of managing finances;operation;outreach;pharmacologic;Policies;Polysomnography;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Procedures;programs;Progress Reports;Protocols documentation;Psychiatry;Publications;Publishing;recruit;Reporting;Research;Research Personnel;Resources;Rotation;Schedule;scientific organization;Services;Sleep;Sleep disturbances;sleep physiology;sound;Subgroup;Synapses;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;web site;Work;Writing;Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Immunotherapy

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Colorectal cancer is the second leading cause of cancer-related death in the United States. Chemotherapy is used in advanced stage colorectal cancers yet the resistance mechanisms are not fully known. This project is aimed at understanding the role of immune system in regulating chemotherapy response in colon cancer.

PI_NAMEs: LU, JUN  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-cancer;Biliary;Bone Marrow;Breast;Bypass;cancer cell;Cancer Etiology;Cancer Model;Cells;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Cytotoxic Chemotherapy;cytotoxicity;Data;Data Set;Disease;DNA;Dose;Effectiveness;Engraftment;Environment;Fluorouracil;Genes;Head and neck structure;Hematopoietic;Human;humanized mouse;Immune;Immune system;Immunocompetent;Immunodeficient Mouse;immunoregulation;In Vitro;in vivo;Interferon Type I;Interferons;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;mouse model;Mus;Outcome;Pancreas;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Physicians;Play;Production;prognostic;Proteins;Resistance;resistance mechanism;response;RNA;Role;Scientist;Small Intestines;Stimulator of Interferon Genes;STING agonists;Stomach;T-Lymphocyte;Testing;Therapeutic;Treatment Efficacy;treatment response;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;United States;Vertebral column;Work

PROJECT_TITLE: Role of immune regulation in colorectal cancer chemotherapeutic response

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]