ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Cannabis is the third most commonly used substance in the United States and associated with physical harms, psychological harms, and other types of harms. The proposed study will use rigorous methods to examine an important population-level intervention that can increase risk perceptions, knowledge, and recall of cannabis- related harms—warning labels on cannabis packages. The expected outcomes of this project include comprehensive knowledge of cannabis warning regulations in the US, insights from state cannabis regulators, a set of evidence-based cannabis warnings, and information on whether large, evidence-based warnings increase risk perceptions.

PI_NAMEs: KOWITT, SARAH ;RANNEY, LEAH MARIE (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adult;Advertising;Alcohols;Back;Behavior;Cannabis;Cannabis policy;Cannabis retail;Characteristics;Cognitive deficits;Color;Communication;Confusion;cost effective;design;Dryness;Effectiveness;Ensure;Evaluation;evidence base;experimental study;Flowers;Future;Goals;improved;informant;innovation;insight;interest;Intervention;Interview;Knowledge;Label;Legal;Length;marijuana legalization;marijuana use;marijuana user;Mental Health;Methods;National Institute of Drug Abuse;novel;Outcome;Persons;Pharmaceutical Preparations;Policies;Population;primary outcome;psychologic;Public Policy;Publishing;Randomized;Regulation;Reporting;Research;Respiratory Disease;Risk;risk perception;Sampling;substance use;System;Text;Tobacco;United States;Use Effectiveness;Vehicle crash;warning label

PROJECT_TITLE: Developing and Strengthening Cannabis Warnings

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants with significant morbidity and mortality. Currently, there are no specific treatments or predictive tests for this devastating ailment. This project will build and validate models to predict development of NEC based on variation of total bile acids obtained from feces of premature infants at Banner University Medical Center- Tucson and Vanderbilt University Medical Center.

PI_NAMEs: HALPERN, MELISSA D (contact);WEITKAMP, JOERN-HENDRIK

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Academic Medical Centers;Admission activity;Age;Area;Arizona;Back;Bile Acids;Biological Markers;Birth;Birth Weight;Clinical;clinical diagnosis;cohort;Confidence Intervals;cytotoxic;Development;Diagnosis;Diagnostic tests;Disease;Emergency Situation;Enrollment;Enteral Feeding;Enterohepatic Circulation;Experimental Models;Feces;Freezing;Functional disorder;gastrointestinal;Gestational Age;Homeostasis;Hour;improved;Incidence;Infant;Inflammation Mediators;Intervention;intestinal epithelium;Intestines;Lead;Life;Liver;Logistic Regressions;Measures;Modeling;Morbidity - disease rate;mortality;Necrotizing Enterocolitis;Neonatal;Neonatology;novel;Nursing Staff;Participant;Pathogenesis;Patients;Play;predictive marker;predictive modeling;predictive test;premature;Premature Infant;prognostic assays;prospective;Publications;Research;Risk Factors;ROC Curve;Rodent Model;Role;sample collection;Sampling;Specificity;Specimen;stool sample;Time;Universities;Variant

PROJECT_TITLE: Assessing Variation in Fecal Bile Acids as a Novel Early Indicator of Necrotizing Enterocolitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: TEMPE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative The objectives of this research are to characterize hippocampal and memory aging trajectories, and identify the combination of MRI measures that best predict accelerated memory decline in middle-age and older adults with autism spectrum disorder (ASD), compared to matched non-ASD. This is relevant to public health because findings will advance fundamental knowledge of brain aging vulnerabilities and mechanisms in ASD. Our long-term goal is identifying biomarkers and intervention targets for precision medicine care of aging autistic adults.

PI_NAMEs: BRADEN, BRITTANY BLAIR (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adult;adult with autism spectrum disorder;Age;age acceleration;age related;Aging;aging brain;aging mechanism;aging related disease;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic;Biological Markers;Biological Models;biomarker development;biomarker identification;Brain;cardiovascular health;Caring;Cerebral Palsy;Child;clinical predictors;Cognition Disorders;Cognitive;Cognitive aging;cohort;Data;Dementia;dementia risk;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Early Onset Alzheimer Disease;Elderly;Episodic memory;executive function;Exercise;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;Genomics;Goals;Grant;hemodynamics;high risk;Hippocampus;Imaging Techniques;Impaired cognition;improved;in vivo;Intellectual functioning disability;interest;Intervention;Investigation;Knowledge;Lead;Least-Squares Analysis;life time cost;Link;Literature;long term memory;Longitudinal cohort;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Medical;Memory;Memory Loss;Methods;middle age;mild cognitive impairment;Modality;Modeling;modifiable risk;Molecular;Monitor;MRI Scans;multilevel analysis;Multimodal Imaging;multimodality;Nerve Degeneration;Neurobiology;neuroregulation;non-invasive imaging;novel;older adult;Outcome;Paper;Participant;Pattern;personalized care;Persons;Population;Positron-Emission Tomography;precision medicine;Prevalence;Public Health;Publishing;Quality of life;Reporter;Research;Research Design;Risk Factors;risk variant;Role;segregation;Series;Short-Term Memory;Signal Transduction;Study models;Synapses;Testing;therapy development;Thinness;Time;United States National Institutes of Health;verbal;Visit;Visual;Visuospatial;Water;white matter

PROJECT_TITLE: The Aging Autistic Brain: Multi-modal imaging to predict accelerated memory decline

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE A national emergency in child mental health has been declared by multiple specialty organizations during the COVID-19 pandemic. While telehealth services have increased rapidly across the nation as promoted by government policy changes during the pandemic, no study to date has examined the extent to which state telehealth policy changes help address the national emergency and reduce disparities in child mental health care between mental health professional shortage areas and non-shortage areas. This proposed study aims to fill the gap through longitudinal analyses of comprehensive primary and secondary data.

PI_NAMEs: YU, HAO  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adoption;Adult;Advocate;Affect;Area;Categories;Characteristics;Child;Child Care;Child Health;Child health care;Child Health Services;Child Mental Health;child mental health service;Complement;Country;COVID-19;COVID-19 pandemic;Data;Data Files;Development;digital health;Disparity;disparity reduction;Drug usage;Emergency Situation;Employee;Equity;Ethnic Origin;Evaluation;Expenditure;experience;Future;Goals;Government;Growth;Health;health care availability;health care service utilization;health equity;Health Personnel;Health Policy;health professional shortage areas;Health Services;Health Services Accessibility;Healthcare Systems;improved;innovation;Insurance Coverage;Interview;Licensure;Location;longitudinal analysis;Longitudinal Surveys;Medial;medical specialties;Mental disorders;Mental Health;Mental Health Services;minority children;pandemic disease;Physician Executives;Policies;Policy Maker;Prevalence;Provider;Psyche structure;Public Health;Race;Reporting;Research;residence;response;sociodemographics;Source;Surveys;telehealth;Time;underserved area;Vulnerable Populations

PROJECT_TITLE: State Telehealth Policies and Mental Care for Children in Underserved Areas

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (04)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Estrogen;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE A decrease in bone mass is one of the most common features of menopause (loss of estrogens), but the mechanisms responsible for this effect remain unknown. The aim of the work proposed in this application is to identify the means by which estrogens decrease the number and activity of the bone-resorbing cells. Knowledge gained with these studies may prove useful for the development of therapies that can treat osteoporosis.

PI_NAMEs: ALMEIDA, MARIA JOSE (contact);KIM, HA-NEUI

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adaptor Signaling Protein;Alleles;antagonist;Apoptosis;Apoptotic;Attenuated;bak protein;Bax protein;BCL2 gene;Binding;bone;bone loss;bone mass;Bone Matrix;bone resorbing activity;Bone Resorption;Bone Resorption Inhibition;Cell Death;Cell Differentiation process;Cell fusion;Cell Lineage;Cells;Cessation of life;Complex;cytokine;Development;Enzymes;ESR1 gene;Estradiol;Estrogen deficiency;Estrogens;Experimental Designs;Foundations;fracture risk;Gene Expression Profile;Genetic;Giant Cells;Immune response;In Vitro;in vivo;Inflammatory;insight;Knowledge;Lactobacillus brevis;loss of function;Macrophage;Measures;Mediating;member;Membrane;Menopause;Metabolism;Microscopy;Mitochondria;Molecular;Mus;Myelogenous;Myeloid Cells;NADH;NADH oxidase;novel;osteoclast progenitor;osteoclastogenesis;Osteoclasts;Osteoporosis;Ovariectomy;overexpression;Oxidation-Reduction;Pathway interactions;Population;prevent;Process;Production;progenitor;Protein Family;Proteins;receptor;recruit;Regulation;Respiration;response;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skeleton;Testing;therapy development;Time;TNFSF11 gene;tool;TRAF6 gene;Water;Work

PROJECT_TITLE: Antagonism of RANKL signaling by estrogen in osteoclasts

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Missing a liver lesion, or other subtle pathology, can have life-or-death consequences for patients. However, techniques that change CT images in a non-linear fashion are being commercially deployed based on simplistic assessments, such as noise reduction, rather than on maintenance of diagnostic performance. This work will provide the CT community tools to assess diagnostic performance for new CT imaging methods as they become available, facilitating optimization of dose reduction and ensuring safe clinical deployment.

PI_NAMEs: GONG, HAO ;MCCOLLOUGH, CYNTHIA H (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Abdomen;accurate diagnosis;Algorithms;Appearance;appropriate dose;Award;Back;Cessation of life;Clinical;clinical practice;Clinical Research;Communities;Consensus;Data;data library;Data Set;deep learning;deep learning model;denoising;Detection;Diagnostic;Disease;Dose;Ensure;Evaluation;Exposure to;Eye;FDA approved;Goals;Human;Image;image reconstruction;imaging modality;Imaging Techniques;innovation;Investments;Knowledge;Lesion;Libraries;Life;Liver;Liver diseases;Maintenance;man;Manufacturer;Metastatic Neoplasm to the Liver;Methods;Modeling;Morphologic artifacts;Noise;novel;Organ;Pathology;Patient imaging;Patients;Performance;Population;Process;Protocols documentation;Radiation Dose Unit;Radiation exposure;radiologist;Reader;reconstruction;Reporting;Resources;Scanning;Signal Transduction;simulation;soft tissue;Software Tools;Techniques;Technology;Testing;Time;tool;Training;Validation;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Diagnostic performance assessment and dose optimization using patient CT images: Application to deep-learning CT reconstruction and denoising technologies

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Liver Disease;Microbiome;Prevention

ORG_CITY: LAS VEGAS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project narrative Public health relevance: Clostridium difficile infection (CDI) is a deadly hospital-borne infection. C. difficile spore germination is a required step for CDI onset. The goal of this proposal is to identify stable, non-toxic, and effective anti-germinants to prevent CDI .

PI_NAMEs: ABEL-SANTOS, ERNESTO V (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acids;Address;Amides;Anabolism;analog;Aniline;Animal Testing;Anti-Bacterial Agents;antibiotic-associated diarrhea;Antibiotics;Bacteria;Benchmarking;benzimidazole;benzothiazole;Benzoxazoles;bile salts;Binding;Binding Proteins;Binding Sites;Cells;Cessation of life;chenodeoxycholate;Cholates;Clostridium difficile;Colitis;Complex;cost estimate;cytotoxicity;Data;dehydroxylation;deoxycholate;Development;Diarrhea;Disease;dosage;Drug Kinetics;Enterohepatic Circulation;Environment;Epithelium;Epitopes;experience;Funding;Genetic Transcription;Germination;Goals;gut microbiome;gut microbiota;Hamsters;Harvest;Health Care Costs;Healthcare Systems;Homeostasis;Hospitalization;Hospitals;Human;Hydrolysis;Hydroxylation;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;Infection;infection risk;Intestines;Knock-out;Lead;Lethal Dose 50;Libraries;Link;Liver;Mediating;Metabolic;Metabolic Biotransformation;Metabolism;meter;Methods;microbial;microbiota;Microsomes;Molecular;Mus;Mutagenesis;Patients;Permeability;Pharmaceutical Chemistry;Pharmacodynamics;pre-clinical;Predisposition;prevent;Process;programs;Property;prophylactic;Prophylactic treatment;Proteins;Proteomics;public health relevance;Quantitative Structure-Activity Relationship;Quinazolines;Regulation;Relapse;Reproduction spores;Rodent;Role;RTN4 gene;Scheme;Side;Sterane;Sum;symptomatology;Symptoms;Taurine Cholate;Testing;Toxic effect;Toxicity Tests;Toxin;Translations;Uncertainty;uptake;Vancomycin

PROJECT_TITLE: Using bile salt metabolism to modulate CDI prophylaxis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-M (02)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE A planned longitudinal cohort study will enroll individuals to study the immunological response to syphilis infection and transcriptome of Treponema (T.) pallidum, the bacterium that causes syphilis, using state-of-the-art omics approaches. Our proposed study is a continuation of our current work and will inform global syphilis research and advance knowledge of syphilis pathogenesis toward improving diagnostics and vaccine development.

PI_NAMEs: KLAUSNER, JEFFREY DAVID (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Aftercare;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Area;Attenuated;Bacteria;biobank;Biological;Biological Assay;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;Clinical;clinical diagnosis;Clinical Management;clinical research site;cohort;Complement;Complex;Data;Databases;Detection;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic development;diagnostic signature;Diagnostic tests;Disease;Enrollment;Epidemiology;experience;Flow Cytometry;follow-up;Frequencies;Funding;Future;Genetic Transcription;global health;Globus Pallidus;Goals;Grant;Humoral Immunities;Immune;Immune response;Immunity;immunogenic;Immunologics;Immunology;immunoreactivity;improved;In Vitro;Incidence;Individual;Infection;Knowledge;Link;Longitudinal cohort study;memory CD4 T lymphocyte;Methods;Modernization;National Institute of Allergy and Infectious Disease;novel;novel diagnostics;Outcome;Participant;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Peru;Population;prevent;Prevention;Process;prospective;Prospective Studies;Proteins;Proteomics;Recording of previous events;recruit;Recurrence;Research;Research Infrastructure;Research Personnel;Resources;response;sample collection;Sampling;Serodiagnoses;Serology;Serology test;Serum;Small Business Innovation Research Grant;Standardization;Symptoms;Syphilis;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;Treponema pallidum;United States National Institutes of Health;Vaccine Design;vaccine development;vaccine discovery;Whole Blood;Work

PROJECT_TITLE: Syphilis Immunology and Biology to Improve Clinical Management and Vaccine Design

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Washington, DC

ORG_NAME: SMITHSONIAN INSTITUTION

ORG_STATE: DC

PHR: Project Narrative  This proposal aims to elucidate the physiological role and downstream effects of follicular fluid EV (ffEV) miRNAs on cumulus-oocyte complexes (COCs) in the domestic cat model. Building on our recent work in evaluating the roles of extracellular vesicles (EVs) in mediating gamete function and our experience in biomimetic/microfluidic cell culture systems, we will (1) determine the influence of gonadotropin stimulation regimes on EV production in vitro using a dynamic microfluidic system; and (2) specifically modulate (via inhibition or supplementation of miRNA mimics) EV miRNA cargo and assess the subsequent effects on vitrified oocyte developmental competence and downstream cell cycle pathways. These studies will generate new insight into the utility of ffEVs for future assisted reproduction applications, including oocyte vitrification, for human fertility preservation and genome rescue of valuable animal models.

PI_NAMEs: NAGASHIMA, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Age;Animal Model;Animals;assisted reproduction;Assisted Reproductive Technology;Binding;Biogenesis;biological adaptation to stress;Biological Availability;Biomimetics;Biotinylation;Birth Rate;blastocyst;Cattle;Cell Compartmentation;Cell Culture System;Cell Cycle;Cell Cycle Progression;cell injury;Cell secretion;Cells;Cellular Stress;Clinical;clinical effect;clinically relevant;Communication;Competence;Complex;Cryopreservation;Development;egg;Embryo;embryo quality;Embryonic Development;Engineering;Estrus;Evaluation;experience;extracellular vesicles;Felis catus;fertility preservation;Follicle Stimulating Hormone;Follicular Fluid;Future;Gene Expression;gene function;Generations;Genome;Germ Cells;Gonadotropins;granulosa cell;Heat-Shock Proteins 70;Heat-Shock Response;Hormones;Human;Human Chorionic Gonadotropin;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;interest;Intracytoplasmic Sperm Injections;Kinetics;Knowledge;Laboratories;Lipid Binding;Live Birth;Luteinizing Hormone;Mediating;Meiosis;member;Membrane Lipids;Messenger RNA;microfluidic technology;Microfluidics;MicroRNAs;mimetics;Modeling;Modification;Molecular;Mothers;Mus;oocyte cryopreservation;oocyte quality;Oocytes;Outcome;Ovarian;Ovarian Stimulations;Ovum;Pathway interactions;Pattern;Physiological;Prevalence;Probability;Production;protein expression;Proteins;Proteome;Protocols documentation;Recovery;Recovery Support;Reporter;reproductive;Research;Role;Series;Signal Pathway;simulation;Supplementation;System;targeted delivery;Therapeutic;Time;trafficking;transcriptome;transcriptome sequencing;United States;uptake;Vesicle;Woman;Work

PROJECT_TITLE: Investigating the physiological significance of follicular extracellular vesicle miRNAs: From gonadotropin control of biogenesis to application in oocyte vitrification

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dietary Supplements;Microbiome;Neurosciences;Nutrition;Obesity;Prevention

ORG_DEPT: BIOLOGY

PHR: Project Narrative  Unhealthy diets high in sugar and saturated fat (a “Western diet”) are commonly consumed by children and are associated with both obesity and cognitive impairments. The hippocampus is a brain region that regulates memory function and food intake control, and this region is particularly vulnerable to early life Western diet consumption. Here we investigate the biological and behavioral mechanisms through which early life consumption of a Western diet negatively affects memory function and feeding-related behaviors later in life.

PI_NAMEs: KANOSKI, SCOTT EDWARD (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acetylcholine;Adolescent;Adult;Affect;Alzheimer's disease related dementia;bacterial genome sequencing;Behavioral Mechanisms;Bifidobacterium;Binding;Biological;Brain;Brain region;Calories;Child;cholinergic;Cholinergic Receptors;Cognition;Consumption;Data;Dementia;dementia risk;Development;Diet;dietary;Dietary Factors;Dietary Intervention;Disease;Eating;Eating Behavior;energy balance;Energy Intake;Energy Metabolism;Environment;experimental study;Feeding behaviors;Food;Functional disorder;Funding;Gastrointestinal Process;glucagon-like peptide 1;good diet;gut microbiome;Hippocampus;Homeostasis;human model;Hyperphagia;Impaired cognition;in vivo;in vivo imaging;Intestines;islet amyloid polypeptide;Lactococcus;Life;life span;Link;Mediating;Memory;Memory Disorders;Memory impairment;Metabolic;Metabolism;microbial;microbiome;middle age;Modeling;Motor Activity;neural;neurobiological mechanism;Neurocognition;Neurocognitive;neuromechanism;novel;Obesity;Outcome;Pancreas;Pathway Analysis;Performance;pharmacologic;Physiological;Population;Probiotics;Process;programs;Publications;Rattus;respiratory;response;Risk;Rodent;Rodent Model;Role;Satiation;saturated fat;Signal Transduction;Stomach;sugar;Testing;Unhealthy Diet;Visuospatial;Weight Gain;western diet;Work

PROJECT_TITLE: Interactions between diet and cognition

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative: Genes encoding SWI/SNF complex subunits are mutated in over 20% of all human cancers, including the devastating childhood Rhabdoid Tumor. We have identified a gene that, when deleted, specifically kills rhabdoid cells. The proposed studies are designed to determine the normal function of this gene and the mechanisms by which its loss kills these cancers and, secondly, to explore novel approaches to circumvent therapeutic resistance in these aggressive cancers.

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Affect;Automobile Driving;Binding;Biological Models;Cancer cell line;cancer genome;Cell Proliferation;Cell Survival;Cells;Childhood;Chromatin;Chromatin Remodeling Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR screen;Data;Deacetylase;Dependence;design;Diploidy;Drosophila snf protein;Drug resistance;Enhancers;Epigenetic Process;experimental study;EZH2 gene;Family member;FDA approved;Frequencies;Funding;Gene Deletion;Gene Expression;gene function;gene product;gene repression;Gene Silencing;Genes;Genetic Transcription;genome-wide;Glues;Goals;Grant;Growth;Human;in vivo evaluation;inhibitor;insight;interest;Knowledge;Lead;Link;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Modeling;Molecular;mutant;Mutate;Mutation;neoplastic cell;novel;novel strategies;novel therapeutics;Polycomb;programs;promoter;Proteins;recruit;Recurrence;Regulation;Regulator Genes;Resistance;resistance mechanism;Rhabdoid Cell;Rhabdoid Tumor;Role;Sarcoma;SMARCB1 gene;Specific qualifier value;Structure;success;SWI/SNF Family Complex;System;Testing;Therapeutic;therapy resistant;Transcriptional Activation;Transcriptional Regulation;Translating;Tumor Cell Line;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;virtual;Work;Xenograft procedure

PROJECT_TITLE: Role of the SWI/SNF complex in tumor suppression

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hematology;Human Genome;Liver Disease;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: The goal of this work is to improve our knowledge and increase the efficiency of adeno- associated viral vectors for genome editing approaches. This will improve current genome editing/therapy approaches, which may provide lifelong treatment for patients suffering from genetic diseases.

PI_NAMEs: KAY, MARK A (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: adeno-associated viral vector;Adult;Albumins;Amino Acids;Animals;Antibodies;arm;Catalytic RNA;Cell Culture Techniques;Cell division;Cells;clinical application;Clinical Trials;clinically relevant;Code;Complementary DNA;Cultured Cells;Data;design;Disease;Disease susceptibility;DNA;Early treatment;Event;Exons;Factor IX;Gene Modified;gene product;Gene Targeting;Gene Transfer;Genes;Genetic Diseases;Genetic Screening;Genetic Transcription;Genome;genome editing;genomic locus;Genomics;Goals;Growth;Hemophilia A;Hemophilia B;Hemorrhage;Hepatic;Hepatocyte;hepatoma cell;Hereditary Disease;High-Throughput Nucleotide Sequencing;homologous recombination;Human;Human Genetics;human model;humanized mouse;improved;in vivo;insight;integration site;interest;Introns;Knowledge;Left;Life;Liver;Location;Maps;Mediating;Messenger RNA;methylmalonic aciduria;Modeling;Molecular;mouse model;Mus;nanopore;neonatal mice;Nonhomologous DNA End Joining;novel strategies;nuclease;Other Genetics;Patients;Phase I/II Clinical Trial;Process;Proteins;Recombinant adeno-associated virus (rAAV);Ribosomes;RNA;RNA immunoprecipitation sequencing;Scheme;sequencing platform;Site;Source;success;targeted sequencing;Technology;Terminator Codon;Testing;Therapeutic;therapeutic gene;therapeutic protein;Transcript;Transgenes;Translating;vector;vector genome;Work

PROJECT_TITLE: Hepatic gene transfer for the treatment of hemophilia B and other genetic diseases

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: OMAHA

ORG_NAME: CHN NEBRASKA

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as more than 80% of Americans do not meet physical activity levels associated with reduced cancer risk. Built environment approaches are recommended to enhance population physical activity levels, but are difficult to implement by community organizations without tailored support. The proposed study will leverage an established partnership with Montana State University to select and evaluate community-driven implementation strategies to improve the uptake of built environment approaches in the Cooperative Extension System.

PI_NAMEs: BALIS, LAURA  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Address;Adoption;American;Bicycling;built environment;cancer risk;cancer type;Chronic Disease;Clinical;Communities;community engaged approach;community engagement;community organizations;community partners;community setting;contextual factors;County;Data;Decision Making;Educational Status;Effectiveness;effectiveness/implementation design;Environment;evidence base;Evidence based intervention;Face;Faculty;follow-up;Future;Goals;Government;Grant;Health;Hybrids;implementation cost;implementation outcomes;implementation strategy;improved;Individual;Infrastructure;innovation;interest;Intervention;Letters;life span;Location;member;Methods;Monitor;Montana;Outcome;Partnership Practice;Pattern;Persons;Physical activity;pilot test;Policies;Population;Prevention strategy;preventive intervention;primary outcome;Primary Prevention;Process;programs;Public Health;Quasi-experiment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Research;Research Personnel;research to practice;Resources;scale up;Series;Services;Shapes;System;Techniques;tenure track;Testing;Time;Training;Translating;Universities;University resources;uptake;Walking;Wheelchairs;Work

PROJECT_TITLE: Built environment approaches to physical activity: Testing community-driven implementation strategies

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Genetics;Nutrition;Sleep Research

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Cellular pathways implicated in aging and longevity are under circadian regulation, and in turn, aging leads to circadian disruption and damped circadian gene expression. We hypothesize that age-related declines in circadian gene expression affect longevity pathways and health and therefore, interventions that can rescue circadian function may extend healthspan and lifespan. In addition, we have found that inflammation is a major contributor to aging and is rescued by circadian alignment of feeding under caloric restriction and so will test the candidate, Interleukin-1b, as a mediator of aging in a circadian context.

PI_NAMEs: GREEN, CARLA B.;TAKAHASHI, JOSEPH S (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adopted;Affect;age effect;age related changes;age related decline;Aging;aging related;ARNTL gene;Autopsy;Bacterial Artificial Chromosomes;behavioral study;Biological Process;Body Weight;Caloric Restriction;Calories;Cause of Death;Cells;Chronic;circadian;Circadian Dysregulation;Circadian gene expression;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical Trials;Complex;Consumption;Coupled;cytokine;Deterioration;Diet;Dietary Intervention;dietary restriction;Eating;effective intervention;experimental study;extend lifespan;Fasting;feeding;feeding schedule;Female;Food;Food Patterns;frailty;Gene Expression;gene function;gene therapy;Genes;Genetic Enhancement;Genetic Transcription;Genome Stability;Goals;Growth;Health;healthspan;healthy aging;Hour;Human;improved;indexing;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;insight;Interleukin-1 beta;Interleukins;Intervention;Knockout Mice;Laboratories;life span;Link;Liver;Longevity;Longevity Pathway;Longitudinal Studies;loss of function;male;Measures;Mediating;Mediator;Metabolism;model organism;Morbidity - disease rate;Mus;Nodal;nonhuman primate;novel;Nutrient;overexpression;Overnutrition;Oxidative Stress;Pathology;Pathway interactions;Pattern;Periodicity;Phase;Phenotype;Population;pro-aging;Rodent;Running;Signal Transduction;System;Testing;Time;Time-restricted feeding;Tissues;Trans-Activators;transcription factor;Transgenic Mice;Work

PROJECT_TITLE: Circadian Rhythm and Lifespan

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative While approximately 10% of human birth defects, including congenital heart defects, affect early neural crest development, the molecular mechanisms underlying these defects are largely unknown. The proposed experiments promise to illuminate the molecular and cellular processes that result in formation of the cardiac neural crest. The results of this study may inform upon diagnosis, therapeutic intervention and also yield approaches guiding maintenance of neural crest cells in the developing heart for the purpose of repair and regeneration.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Ablation;Adult;Affect;Area;ATAC-seq;Biological;Cardiac;Cardiac ablation;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cardiovascular system;Cell Physiology;cell type;Cells;Chick;Chick Embryo;Color;Congenital Abnormality;Congenital Heart Defects;Coupled;Coupling;craniofacial;CRISPR/Cas technology;Data;Defect;Development;Diagnosis;Dorsal;Ectopic Expression;Embryo;embryo cell;Embryonic Heart;Epigenetic Process;experimental study;FOXC2 gene;FOXP1 gene;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Heart;heart cell;heart function;hindbrain;Human;Injury;Long-Term Effects;loss of function;Maintenance;Mammals;Mediating;migration;Molecular;multipotent cell;Mus;Natural regeneration;Neural Crest;Neural Crest Cell;Neurons;Newborn Infant;novel;Pathway interactions;Peripheral Nervous System;Persistent Truncus Arteriosus;Population;postnatal;programs;Property;regenerative;Regenerative Medicine;Regulatory Element;repaired;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Skeleton;Smooth Muscle;SOX8 gene;Testing;Therapeutic Intervention;Time;transcriptome sequencing;Transforming Growth Factor beta;Up-Regulation;Ventricular;Viral;Virus;Zebrafish

PROJECT_TITLE: Role of the cardiac neural crest in development and regeneration

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: ORTHOPEDICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The proposed studies will present a novel factor, or a key modifier of GCase, a new clinical relevant GD animal model that recapitulate the human disease in multiple organs, and provide a better understanding of pathogenesis of Gaucher Diseases. Identification of novel molecule and its derivative also provides the basis for developing the novel therapeutic treatments in Gaucher Diseases, in particular the neuronopathic Gaucher Diseases.

PI_NAMEs: LIU, CHUANJU  (contact);SUN, YING

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acceleration;Affinity;Age;aged;alpha synuclein;Amino Acids;Animal Disease Models;Animal Model;antagonist;Binding;Biological;Biological Assay;Biological Markers;Biological Products;blood-brain barrier crossing;blood-brain barrier penetration;Brain;brain tissue;C-terminal;cell type;Central Nervous System;Central Nervous System Diseases;Ceramide glucosyltransferase;Clinical;clinically relevant;Complement 5a;complement system;Data;Development;Disease;disease model;disease phenotype;Dose;early onset;enzyme replacement therapy;Event;Exhibits;Funding;Gaucher Disease;Gaucher's Cell;Generations;Genes;glucosylceramidase;Glucosylceramides;glucosylsphingosine;GRN gene;Hepatomegaly;human disease;in vivo;Inflammation;Inflammatory;Interruption;Knockout Mice;Lysosomal Storage Diseases;Lysosomes;Macrophage;Mediating;Medical;member;Modeling;Molecular;mouse model;Mus;Mutation;N-terminal;Neurologic Deficit;Neuronopathic Gaucher Disease;new therapeutic target;novel;novel diagnostics;novel therapeutics;Onset of illness;Organ;Organoids;Ovalbumin;Parkinson Disease;Pathogenesis;Pathogenicity;Patients;Penetration;Peptides;PGRN gene;Pharmaceutical Preparations;Phenotype;Pilot Projects;Play;Production;protein protein interaction;Proteins;Research;Role;screening;Signal Transduction;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tubular formation;Up-Regulation;Variant;Visceral

PROJECT_TITLE: Progranulin: A Novel Gene in Gaucher Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-A (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Zika virus infections during pregnancy are linked to fetal mortality and morbidities often characterized by microcephaly and other congenital Zika syndrome developmental disorders, and this characteristic appears to be highly unique to Zika virus among flaviviruses. Here, we present preliminary evidence showing that spread of this virus at the maternal-fetal interface is linked to intercellular conduits known as tunneling nanotubes, which we show are induced in the placenta during ZIKV infection. We propose to investigate the relationship between the Zika virus and tunneling nanotubes in both cell and mouse models to establish a previously undescribed and important cellular mechanism for the vertical transmission of the virus that can be targeted for therapies that intervene with congenital Zika syndrome.

PI_NAMEs: JOSE, JOYCE  (contact);MYSOREKAR, INDIRA U

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Actins;Adverse effects;Affect;Affinity Chromatography;Antibody Therapy;Autophagocytosis;Biological Assay;Brain;cell injury;Cell model;cell type;Cells;Cellular Metabolic Process;Characteristics;Coculture Techniques;Collaborations;confocal imaging;Confocal Microscopy;congenital zika syndrome;Culicidae;Data;design;developmental disease;Epidemic;Experimental Designs;fetal;Fetal Development;Fetal Growth Retardation;Fetal Mortality Statistics;Fetal Tissues;Fetus;Flavivirus;Flow Cytometry;Future;Gene Expression;Genes;genetic information;genomic RNA;Genomics;Genus Hippocampus;Guillain Barré Syndrome;Horizontal Disease Transmission;Human;imaging approach;In Situ Hybridization;in vivo;Infection;insight;International;knock-down;Knock-out;Knowledge;Label;Libraries;Link;Lipids;Macrophage;Mammalian Cell;Mass Spectrum Analysis;Maternal-Fetal Exchange;Maternal-Fetal Transmission;Metabolic;Microcephaly;Mitochondria;Molecular;Morbidity - disease rate;Mothers;mouse model;Mus;mutant;Nanotubes;Nature;Neurons;neutralizing antibody;new epidemic;Nonstructural Protein;novel;Organelles;Outcome;particle;Pathogenesis;Pathway interactions;Persons;Placenta;placental infection;placental trophoblasts;Plaque Assay;Pregnancy;Pregnancy Complications;pregnant;prevent;Process;Protein Region;Proteins;public health emergency;Quantitative Reverse Transcriptase PCR;Regulation;Reproduction;Resolution;RNA;RNA Transport;Role;Scientist;Signal Pathway;Signal Transduction;Spontaneous abortion;Stains;Syncytiotrophoblast;targeted treatment;Testing;Therapeutic Intervention;Time;Tissues;tool;transcriptomics;transmission process;trophoblast;Vertical Transmission;Viral;Viral Load result;viral RNA;viral transmission;Virion;Virus;Virus Assembly;Virus Replication;West Nile virus;Western Blotting;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Mechanisms of tunneling nanotube formation by ZIKV NS1 in viral host interactions at the maternal-fetal interface

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Disrupted sleep is a common and persistent symptom after traumatic brain injury, which can significantly complicate recovery. Chronic disturbances in sleep patterns may induce adverse changes in cognitive performance and over time lead to memory dysfunction. However, the mechanisms underlying cognitive deficits due to chronic sleep disruption following traumatic brain injury remain poorly understood. To improve quality of life in Service Members and Veterans with traumatic brain injury, an understanding of the varied mechanisms triggered by traumatic brain injury is required to prevent or optimally manage cognitive recovery over time post injury. Therefore, the goal of this project is to interrogate chronic sleep disruption and related cognitive deficits using a clinically relevant large animal model of traumatic brain injury.

PI_NAMEs: ULYANOVA, ALEXANDRA V. (contact)

PROJECT_TERMS: Acute;Address;Affect;Animal Model;Animals;Behavior;Behavior assessment;behavior test;Biological Markers;Brain;brain dysfunction;Brain Injuries;Brain region;Characteristics;Chronic;clinically relevant;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive recovery;cognitive testing;Cognitive Therapy;cohort;common symptom;controlled cortical impact;Coupling;Diagnosis;Electroencephalography;Electrophysiology (science);Family suidae;Goals;Hippocampus;Histopathology;Impaired cognition;Impairment;Implant;improved;in vivo;injured;Injury;innovation;insight;Intervention;Lead;long term memory;Memory;memory consolidation;Memory impairment;Military Personnel;Mission;Modeling;Monitor;Motor;Neocortex;neocortical;neuropathology;neurophysiology;neuroregulation;Nonpharmacologic Therapy;novel;Outcome;Outcome Study;persistent symptom;Polysomnography;potential biomarker;prevent;Prognostic Marker;prognostic value;psychologic;Quality of life;Recording of previous events;Recovery;Refractory;rehabilitation research;Research;research and development;Research Personnel;Sensory;service member;Services;Site;Sleep;Sleep disturbances;sleep pattern;sleep spindle;Slow-Wave Sleep;Social Functioning;Testing;Time;tool;translational approach;Trauma;Traumatic Brain Injury;treatment strategy;Veterans;wireless

PROJECT_TITLE: Chronic sleep disruption as prognostic biomarker of cognitive recovery following traumatic brain injury.

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Cherenkov Excited Luminescence Molecular Sensing (CELMS) was invented to probe molecular tracers of tumor metabolism in vivo, utilizing a linear accelerator (Linac) as the x-ray source with a high-resolution, steerable beam. This renewal period will develop a translatable version of the technology that can work with any Linac, through key steps in low cost hardware, open source software, unique metabolic probes, and comparisons in large animal imaging for radiobiology applications.

PI_NAMEs: POGUE, BRIAN WILLIAM (contact);VINOGRADOV, SERGEI

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: absorption;Academic Medical Centers;Acidity;Adult;Algorithms;Anatomy;animal imaging;Animals;arbitrary spin;biomaterial compatibility;Biomedical Engineering;Cell Volumes;Collimator;Color;commercialization;Computer software;cost;Data;design;Detection;detector;Development;Diagnostic;Diffuse;Diffusion;Doctor of Philosophy;Dose;Fluorescence Microscopy;Fractionated radiotherapy;Gel;Heavy Metals;Heterogeneity;Hybrids;Hydrogels;Image;image reconstruction;imaging approach;Imaging Device;Imaging Techniques;Implant;implanted sensor;improved;in vivo;in vivo imaging system;innovation;invention;Investigational Therapies;Knowledge;Light;Linear Accelerator Radiotherapy Systems;Link;Location;luminescence;Maps;Measurement;Medical;Medical center;Metabolic;metabolic imaging;Methodology;metrology;millimeter;Modality;Modeling;Molecular;molecular imaging;Molecular Probes;nanoparticle;novel;novel strategies;open source;optical imaging;Optics;Oxygen;Partial Pressure;Penetrance;Penetration;Pennsylvania;phosphorescence;Photochemistry;Photons;Physics;Physiologic pulse;Plant Leaves;Positioning Attribute;pre-clinical;preservation;Production;Publishing;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radiobiology;Rattus;reconstruction;Recovery;Resolution;response;Roentgen Rays;Sampling;sensor;Shapes;Signal Transduction;small molecule;Source;System;Techniques;Technology;technology platform;Thinness;Time;Tissue imaging;Tissues;tomography;tool;Toxic effect;Tracer;Translations;treatment planning;tumor;tumor metabolism;Universities;Wisconsin;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cherenkov Excited Luminescence Metabolic Sensing (CELMS)

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because it will provide fundamental knowledge about a brain region involved in psychiatric disorders, including depression and addiction. Upon conclusion, we will understand the role of excitation/inhibition balance in activity regulation of the lateral habenula. This discovery will stimulate new therapeutic avenues directed at restoring excitation/inhibition balance in psychiatric disorders.

PI_NAMEs: SHABEL, STEVEN  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: addiction;Affect;Axon;Behavior;Behavioral;Brain;Brain region;cell type;design;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Environment;Equilibrium;Feedback;Future;gamma-Aminobutyric Acid;Globus Pallidus;glutamatergic signaling;Glutamates;Grant;Habenula;Hippocampus;in vivo;Individual;inhibitory neuron;Injections;Interneurons;Investigation;Knock-out;Knowledge;Lateral;Learning;LoxP-flanked allele;Measurement;Measures;Mental Depression;Mental disorders;motivated behavior;Motivation;Mus;Nervous System Physiology;neural circuit;Neurons;neuroregulation;novel therapeutics;Opsin;Output;Phase;Process;Psychological reinforcement;Public Health;Punishment;Rattus;Regulation;Research;response;Rewards;Role;Signal Transduction;Slice;Somatostatin;Swimming;System;Tail Suspension;Testing;transmission process;Viral;Work

PROJECT_TITLE: The function of GABA/glutamate co-release in the habenula

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Microbiome;Nutrition;Skin Cancer

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The microorganisms that normally inhabit the human gut, known as the microbiome, have recently been connected to successful treatment with immunotherapies. The objective of this project is to identify mechanisms of microbiome:immune cell crosstalk that can be modified to improve clinical outcomes for cancer patients. In this project we will determine whether mucosal-associated invariant T cells (MAITs), which recognize vitamin metabolite antigens produced by the microbiome, are one potential connection between the microbiome and responses to immunotherapies.

PI_NAMEs: TOBIN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Accounting;Address;Anabolism;anti-melanoma immunity;anti-PD-1;anti-PD1 therapy;Antibiotic Therapy;Antigens;Bacteria;Binding;Cancer Patient;cancer type;cell killing;Cell Physiology;Cells;checkpoint therapy;Clinical;CTLA4 gene;cytokine;cytotoxic;cytotoxicity;Data;defined contribution;Development;Diabetes Mellitus;Disease;fecal transplantation;Frequencies;germ free condition;gut bacteria;gut microbes;gut microbiome;Human;Immune;Immune checkpoint inhibitor;Immune Targeting;Immunity;Immunologics;Immunotherapy;improved;improved outcome;In Vitro;in vivo Model;Inflammation;Link;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Messenger RNA;Metabolism;Microbe;microbial;microbial products;microbiome;microorganism;Modality;mouse model;Mucous Membrane;Multiple Sclerosis;Mus;neoplastic cell;novel;Outcome;Pathogenesis;Pathway interactions;patient response;Patients;Peripheral Blood Mononuclear Cell;Play;Population;Production;programmed cell death protein 1;recruit;Reporting;Research;response;Riboflavin;Role;Sampling;Site;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;transplantation therapy;treatment response;tumor;Tumor Immunity;tumor microenvironment;Vitamins;Wild Type Mouse

PROJECT_TITLE: MAIT cell: microbiome crosstalk in antitumor immunity

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE In a murine model of Duchenne muscular dystrophy, TY4, a novel synthetic RNA bioinspired by the contents of extracellular vesicles, exerts profound disease-modifying bioactivity. Here, we seek to understand the mechanisms of gene expression changes and anti-fibrotic effects in the heart. Discoveries made here will provide valuable insights for future development of anti-fibrotic agents for a variety of heart diseases.

PI_NAMEs: ROGERS, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Address;Adoptive Transfer;antifibrotic treatment;Antisense Oligonucleotides;aptamer;arginase;Attention;Attenuated;Biological;Bone Marrow;Cardiac;Cardiology;Cardiomyopathies;Caseins;Cause of Death;Cell Survival;Cell Therapy;Cells;Chemicals;chromatin remodeling;coronary fibrosis;cytokine;Data;Development;Disease;DNA biosynthesis;Duchenne cardiomyopathy;Duchenne muscular dystrophy;extracellular vesicles;FDA approved;Fibroblasts;Future;Gene Expression;Genes;Heart;Heart Diseases;heart function;Human Milk;immunogenicity;improved;in vivo;Inflammatory;insight;Intravenous;Left;Macrophage;mdx mouse;Mediating;Mediator;Milk Proteins;mouse model;Mus;Muscular Dystrophies;mutant;new chemical entity;novel;Nucleotides;Oral;Oral Administration;Outcome;paracrine;Pathologic;Patients;Peptides;Pharmaceutical Preparations;precursor cell;prevent;Property;Proteomics;prototype;Rationalization;regenerative therapy;RNA;Small Interfering RNA;Testing;Therapeutic;Therapeutic community technique;Therapeutic Intervention;therapeutic RNA;Thinking;Tissues;transcriptomics;Transgenic Organisms;translational potential;Transplantation;Untranslated RNA;Work

PROJECT_TITLE: Targeting myocardial fibrosis with a novel noncoding RNA in Duchenne muscular dystrophy

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE With the growing global epidemic of obesity, a greater understanding of the link between obesity and colorectal cancer outcomes is an important clinical challenge to address. Using innovative, state-of the-art methods, this study will identify the specific components of adipose tissue distribution and muscle mass that predict colorectal cancer treatment tolerance and survival. By applying a parallel comprehensive assessment of platelet activation, and related biomarkers in the blood, urine, and tumor, we will test, for the first time, the role of thromboinflammation in promoting colorectal cancer progression.

PI_NAMEs: BYRD, DORATHA ARMENTHUS (contact);SHIBATA, DAVID ;ULRICH, CORNELIA M

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Adipose tissue;Age;angiogenesis;Artificial Intelligence;Aspirin;Automobile Driving;Biological;Biological Markers;Biology;Black race;Blood;Blood Platelets;Body Composition;Body fat;Body mass index;Body measure procedure;Cancer Biology;Cancer Prognosis;cancer type;Central obesity;Clinical;clinical application;Clinical Data;clinical predictors;clinically relevant;Colon;colon cancer patients;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Computer software;cost effective;Data;Diagnosis;Diagnostic;Dimensions;Drug or chemical Tissue Distribution;ethnic diversity;Fatty acid glycerol esters;Funding;Geography;IL8 gene;Image;imaging Segmentation;Immunohistochemistry;Individual;individualized medicine;Inflammation;innovation;insight;Interdisciplinary Study;Interleukin-6;Intervention;Investigation;Knowledge;Link;Lymphocyte;Malignant Neoplasms;Measurement;Measures;Mediating;Methodology;Methods;Morbidity - disease rate;muscle form;Neoplasm Metastasis;novel;novel strategies;Obesity;Obesity Epidemic;Outcome;P-Selectin;participant enrollment;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;personalized medicine;pharmacologic;Plasma;Platelet Activation;Platelet Count measurement;Play;point of care;Population;Population Heterogeneity;prognostic;Race;racial difference;racial diversity;Radiology Specialty;RANTES;Rectum;Recurrence;Reporting;Resources;Risk;Role;Sampling;sarcopenia;Scanning;Science;sex;Site;Skeletal Muscle;skeletal muscle wasting;Slice;specific biomarkers;Stratification;survival outcome;Survival Rate;Testing;thromboinflammation;Time;TNF gene;Treatment outcome;treatment strategy;Treatment-related toxicity;tumor;tumor microenvironment;tumor progression;Tumor Tissue;urinary;Urine;Vascular Endothelial Growth Factors;Visceral;X-Ray Computed Tomography

PROJECT_TITLE: Body composition and adiposity-associated thromboinflammation in colorectal cancer prognosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-C (02)]


NIH_SPENDING_CATS: Aging;Genetics

PHR: Project Narrative The goal of this proposal is to investigate the role of the immune regulatory molecule NLRX1 in T cell aging using mouse models. The results of these studies will advance our understanding in aging and immunity.

PI_NAMEs: KANG, INSOO  (contact);KANG, MIN-JONG

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Affect;Age;age related changes;aged;Aging;aging related;anti aging;Attenuated;Binding;Biology of Aging;CD8-Positive T-Lymphocytes;Cell Aging;Cell Survival;Cells;Characteristics;cytokine;Data;exhaustion;Experimental Autoimmune Encephalomyelitis;Family;FRAP1 gene;Gene Expression Profile;Genes;Goals;Heterozygote;hypoxia inducible factor 1;Immune;Immune system;Immunity;Immunologic Stimulation;immunosenescence;improved;in vivo;Infection;Inflammaging;Inflammasome;Inflammation;Inflammatory;inhibitor;insight;interest;Interferon Type II;Interleukin-2;Knock-out;Knockout Mice;Letters;Leucine-Rich Repeat;Link;Lung;Lung Compliance;Macrophage;Malignant Neoplasms;marenostrin;member;Memory;memory CD4 T lymphocyte;microorganism;Mitochondria;Modeling;monocyte;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;mutant;Myelogenous;Myeloid Cells;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel;Nucleotides;old mice;older adult;Pathway interactions;Pattern recognition receptor;Penetration;Peptides;Peripheral Blood Mononuclear Cell;Play;Positioning Attribute;Probability;Production;Proteins;Publishing;Reactive Oxygen Species;Reporting;restoration;Retinoic Acid Receptor;Role;Secondary to;Sepsis;Signal Transduction;Signaling Protein;Sirolimus;SIRT1 gene;System;T memory cell;T-Lymphocyte;Tamoxifen;Testing;transcriptome;transcriptome sequencing;Tretinoin;Viral;Wild Type Mouse

PROJECT_TITLE: Investigating the interface of NLRX1 and immune aging


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rehabilitation;Social Determinants of Health

PHR: PROJECT NARRATIVE We are proposing a population-based study of cerebral palsy (CP) in California to investigate whether fetal exposure to multiple widespread environmental contaminants that may affect hormones in pregnancy contributes to congenital CP. We will also examine the role of maternal thyroid function in CP etiology and utilize a high- resolution untargeted metabolomics approach to elucidate exposure-disease mechanisms. public involved This project has high health relevance since i t will accelerate the generation of knowledge concerning biological mechanisms in CP etiology, inform environmental health policy, and possibly advance the primary prevention of CP.

PI_NAMEs: LIEW, ZEYAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;agricultural activity;agricultural pesticide;anti-cancer research;Archives;Asphyxia;autism spectrum disorder;Behavioral;biobank;Biological;Biological Markers;Birth;Birth Records;Blood;Blood specimen;Brain;California;case control;Cerebral Palsy;Chemical Exposure;chemical group;Chemicals;Child;Childhood;Clinical;Clinical Research;Cognitive;cohort;Communities;Congenital Cerebral Palsy;consumer product;Data;Denmark;design;Development;Diagnostic;Disease;Dryness;Endocrine;environmental chemical exposure;Environmental Exposure;Environmental Health;environmental justice;Environmental Policy;Environmental Pollutants;Environmental Risk Factor;Etiology;Exposure to;fetal;Fire - disasters;Flame Retardants;follow-up;Functional disorder;Generations;Health;Health Policy;Hormonal;Hormones;Human;innovation;Insecta;insight;interest;Joints;Knowledge;Laws;Link;Malignant Childhood Neoplasm;maternal serum;metabolomics;Modeling;modifiable risk;Neonatal;Nervous System;neurodevelopment;Neurologic;Neurologic Effect;neurotoxic;neurotoxicity;Neurotoxins;Newborn Infant;novel;Oxygen;Pathway interactions;Performance;Perinatal;pesticide exposure;Pesticides;phenyl ether;Physiological;Play;pollutant;Pollution;Poly-fluoroalkyl substances;Population;Population Study;Pre-Eclampsia;Pregnancy;Premature Birth;prenatal;prenatal environmental exposure;prenatal exposure;prenatal testing;Prevention;Primary Prevention;Records;Reporting;Research;residence;Resistance;Resolution;Resources;response;Risk;Risk Factors;Role;Sampling;Screening procedure;Self-Help Devices;Serum;sex;social;Spottings;surfactant;System;Testing;thyroid disruption;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;tool;United States;walker;Walking;Wheelchairs

PROJECT_TITLE: Environmental Chemical Exposures and Biologic Markers for Cerebral Palsy (EXPOSE CP)

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Kidney Disease;Microbiome;Organ Transplantation;Transplantation;Urologic Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This proposal will take an important first step in the study of phage therapy for treatment of recurrent urinary tract infection (rUTI) in female kidney transplant recipients (KTR); a common condition that is associated with increasing multidrug resistance, sickness, loss of kidney function and death. The investigators will conduct a randomized phase I/II pilot clinical trial of targeted phage therapy versus placebo in asymptomatic female KTR with a history of rUTI due to Escherichia coli and Klebsiella pneumoniae to assess safety, tolerability, and feasibility of this approach, possible efficacy, and changes in the gut and urinary microbiome during the 180 days of the study. This highly innovative and impactful proposal will provide proof of concept data and also inform the design of a subsequent larger phase III clinical trial of phage therapy for rUTI treatment in KTR and will have broad downstream effects within the fields of infectious diseases and transplantation.

PI_NAMEs: ASLAM, SAIMA  (contact);MARESSO, ANTHONY W

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: acute infection;Acute Renal Failure with Renal Papillary Necrosis;Adverse event;Aftercare;Agar;Agreement;Allografting;Antibiotic Therapy;Antibiotics;Bacteremia;Bacteria;bacterial resistance;bacteriome;Bacteriophages;Bacteriuria;Binding;Biological;Biological Assay;Biological Specimen Banks;Bladder;Cell Cycle;Cell Death;Cells;Cessation of life;Characteristics;Clinical;Clinical Research;Clinical Trials;clinically relevant;combat;Communicable Diseases;comparative efficacy;Creatinine;Data;design;Disease;Drug Kinetics;Emergency department visit;Enrollment;Escherichia coli;Event;experience;Feasibility Studies;Feces;Female;follow-up;Future;Glomerular Filtration Rate;Goals;gut microbiome;Gut Mucosa;Health;Hospitalization;Immune response;improved;In Vitro;Incidence;Infection;Infrastructure;Injury;innovation;Intravenous;Kidney;kidney dysfunction;kidney infection;Kidney Transplantation;Klebsiella pneumoniae;Knowledge;Laboratories;Liquid substance;Lytic;Lytic Virus;Measures;microbial;Microbial Biofilms;microbiome;Mission;Morbidity - disease rate;mortality;Multi-Drug Resistance;National Institute of Diabetes and Digestive and Kidney Diseases;Normal saline;Observational Study;Organism;Outcome;Outcome Study;Participant;pathogen;personalized approach;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Placebos;Polysaccharides;Population;Prediction of Response to Therapy;Predisposition;prevent;primary outcome;Randomized;randomized trial;Recording of previous events;Recurrence;recurrent infection;Renal function;Research;Research Personnel;Resistance;Resistance to infection;response;Risk;Safety;safety assessment;safety outcomes;Sampling;Sepsis;Serum;Testing;Therapeutic;Time;Transplant Recipients;Transplantation;treatment effect;Treatment Efficacy;trial comparing;urinary;Urinary Microbiome;Urinary tract infection;Urine;Uropathogen;virome;Virus;Woman

PROJECT_TITLE: Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: The overall goal of this project is to develop a new platform for the precision delivery of targeted radiotherapies to tumors. Over three specific aims, we will evaluate if proteolytically activated membrane binding peptides can be leveraged to deliver a more substantial dose of ionizing radiation to tumors than conventional radioligand therapies. In parallel, a lead drug candidate conjugated to copper-64 will be translated into cancer patients to assess safety, dosimetry, and pharmacokinetics, as well as the feasibility of tumor targeting using PET.

PI_NAMEs: AGGARWAL, RAHUL ;CRAIK, CHARLES SCOTT;EVANS, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: Active Sites;Adopted;Amino Acids;analog;anatomic imaging;antitumor effect;Benchmarking;Binding;Biological;Biopsy;Blood Circulation;cancer cell;cancer imaging;Cancer Patient;cancer radiation therapy;cancer type;Cell membrane;Characteristics;Clinical;clinical imaging;Clinical Trials;cohort;Complex;Copper;Coupling;CXCR4 gene;Data;Detection;Discipline of Nuclear Medicine;Dissociation;Dose;dosimetry;drug candidate;Drug Kinetics;experience;extracellular;Female;Fibroblasts;first-in-human;FOLH1 gene;Goals;Growth;Histologic;Hour;Human;human study;Image;imaging study;Injections;innovation;interest;Ionizing radiation;Isotopes;Lead;Ligands;male;Malignant Neoplasms;Membrane;Membrane Lipids;Modality;Modeling;Molecular Conformation;Molecular Target;Molecular Weight;Mus;novel;overexpression;Patient imaging;Patients;Peptides;PET/CT scan;Pharmaceutical Preparations;Phase;Phospholipids;Population;Positron-Emission Tomography;Property;Proteins;Proteolysis;Radioisotopes;Radiolabeled;radioligand;Radiopharmaceuticals;receptor;residence;response;Safety;safety assessment;safety testing;serial imaging;Serum;Site;small molecule;Solid Neoplasm;SSTR2 gene;Substrate Specificity;Swelling;targeted delivery;Targeted Radiotherapy;Testing;Therapeutic;therapeutically effective;Time;Toxic effect;Translating;tumor;uptake;Urothelium;virtual

PROJECT_TITLE: Maximizing tumor responses to targeted radiotherapy with a conditionally activated membrane binding probe

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Plasma cells are an essential component of the humoral immune response against infections with pathogens such as influenza by secreting large amounts of neutralizing antibodies. The development of plasma cells is known to be regulated by a network of transcription factors, but the contribution of ion channels and their associated signaling pathways is not understood, which is a missed opportunity from a basic science and translational perspective because ion channels are excellent drug targets as demonstrated by the many drugs modulating ion channel function in the context of cardiovascular and neuropsychiatric diseases.

PI_NAMEs: FESKE, STEFAN  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Affinity;Agammaglobulinemia;Antibodies;Antibody Formation;Antibody Response;Antigens;Apoptosis;ATP2A2;Autoimmune Diseases;Automobile Driving;Autophagocytosis;B cell differentiation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Basic Science;Bicarbonates;Bone Marrow;brain cell;Ca(2+)-Transporting ATPase;Calcium;Cardiovascular Diseases;Cardiovascular system;Cell membrane;cell motility;Cell Physiology;Cell Surface Receptors;cell type;Cells;Cellular Metabolic Process;Charge;Chloride Channels;Chlorides;Clustered Regularly Interspaced Short Palindromic Repeats;Common Variable Immunodeficiency;congenital immunodeficiency;Cytoplasm;Data;Defect;detection of nutrient;differentiation in vitro;Disease;Drug Modulation;Drug Targeting;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelium;extracellular;Generations;Genes;Genetic Screening;Genetic Transcription;Goals;heart cell;Human;Humoral Immunities;IgE;Immune;Immune response;Immunity;Immunization;immunodeficiency;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Impairment;in vivo;Infection;Influenza;influenza infection;influenzavirus;Inherited;Intracellular Membranes;Ion Channel;Ions;kidney cell;lymph nodes;mammalian genome;Mediating;Membrane Lipids;Memory B-Lymphocyte;Mental disorders;Metabolic Pathway;migration;Molecular;Mus;Muscle Cells;Mutation;Nervous System Disorder;Neurons;neuropsychiatric disorder;neuropsychiatry;neutralizing antibody;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;nuclear factors of activated T-cells;Organelles;pathogen;pathogenic virus;Pathology;Pathway interactions;plasma cell development;plasma cell differentiation;Plasma Cells;Plasmablast;Play;prevent;Process;Proteins;Pump;Reporting;response;Role;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Spleen;Structure of germinal center of lymph node;symporter;Therapeutic;transcription factor;transcriptomics;vaccine response;Vascular Smooth Muscle;Zinc;zinc-binding protein

PROJECT_TITLE: Ion channels regulating plasma cell differentiation and humoral immunity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Clinical Research;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Human Genome;Lung;Pediatric;Prevention

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: PROJECT NARRATIVE Atopic dermatitis (AD) and food allergy are among the most common chronic diseases of early childhood. These diseases often occur in the same individuals and many times lead to the development of hay fever and asthma, in a poorly understood process termed the allergic march. In this project we will investigate whether early-life barrier and immune abnormalities of the skin result in not only AD, but affect the overall immune system, leading to the allergic march.

PI_NAMEs: MOORE, CAMILLE M.;SEIBOLD, MAX A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 1 year old;3 year old;Adult;Affect;Age;airway inflammation;Allergens;Allergic;Allergic Disease;Allergic rhinitis;Animal Model;Asthma;Atopic Dermatitis;atopy;Biological Markers;biomarker identification;Birth;cell type;Child;Childhood;Chronic Disease;clinical subtypes;cohort;comorbidity;cytokine;Data;Development;developmental disease;Diagnosis;Disease;disease phenotype;disorder risk;early childhood;early detection biomarkers;early experience;Exhibits;experience;Expression Profiling;Extrinsic asthma;Food Hypersensitivity;Frequencies;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Models;genetic risk factor;Genetic study;genetic variant;genome sequencing;genome wide association study;Hay fever;Health Care Costs;Heterogeneity;Human Genetics;Immune;Immune system;Individual;infancy;Infant;Inflammation;Inflammatory;Lead;Life;longitudinal analysis;Machine Learning;Methods;minimally invasive;Modeling;Molecular;multi-ethnic;Participant;Pathway interactions;Patients;Pattern;Phenotype;Play;Process;programs;prospective;Quantitative Trait Loci;Recurrence;Resolution;Risk;risk sharing;risk variant;Role;Sampling;Skin;Skin Abnormalities;skin barrier;skin disorder;skin organogenesis;Specimen;Subgroup;Systems Biology;Testing;transcriptome;transcriptome sequencing;transcriptomics;TSLP gene;Wheezing;whole genome

PROJECT_TITLE: SUNBEAM Birth Cohort: Deciphering the role of early life skin dysfunction in development of the allergic march

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


PHR: Project Narrative The aim of the proposed research project is to determine how Breakpoint Cluster Region (Bcr) protein regulates the process in vascular endothelial cells to influence atherosclerosis, angiogenesis and peripheral insulin sensitivity, using newly generated mouse models. We anticipate that the new knowledge gained will deepen our understanding of vascular biology through investigation of a novel, previously unappreciated role of Bcr and its adaptor protein PDZK1. Considering the staggering impact of cardiovascular diseases and metabolic syndrome, the goal of the research project is in line with the objectives of the National Institute of Health to address these disorders through medical research.

PI_NAMEs: MINEO, CHIEKO  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affinity;Affinity Chromatography;angiogenesis;Anti-diabetic Drugs;Antiatherogenic;Apolipoprotein A-I;Apolipoprotein A-II;atherogenesis;atheroprotective;Atherosclerosis;Attenuated;attenuation;BCR gene;Beta Cell;Biological Assay;Biology;Blood capillaries;blood glucose regulation;Blood Vessels;cardiometabolism;Cardiovascular Diseases;Carotid Arteries;cDNA delivery;Cell Adhesion;Cell Culture Techniques;cell motility;Cerebral Arterial Diseases;Cerebrovascular Disorders;Clinical Research;Coronary Arteriosclerosis;coronary vascular disease;Disease;Endothelial Cells;endothelial repair;Endothelium;experimental study;Fluorescence Resonance Energy Transfer;Genes;Genetic Variation;Glucose;glucose disposal;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Health;High Density Lipoprotein Cholesterol;Hindlimb;Human;in vivo;Individual;inhibitor;insight;Insulin;Insulin Resistance;insulin sensitivity;Investigation;Ischemia;Knockout Mice;Knowledge;LDL Cholesterol Lipoproteins;Low-Density Lipoproteins;LoxP-flanked allele;Mediating;Medical Research;Metabolic Diseases;Metabolic syndrome;migration;Modeling;monocyte;mouse model;Mus;Muscle;Muscle Cells;mutant;nanoparticle;neovascularization;new therapeutic target;Nitric Oxide Synthase;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Peripheral;Peripheral arterial disease;Peripheral Vascular Diseases;Phenotype;Phosphotransferases;Plasma;Play;Process;programs;Protein Kinase;Protein Region;Protein-Serine-Threonine Kinases;Proteins;receptor;reconstitution;recruit;repaired;Research;Research Project Grants;Resolution;Role;Skeletal Muscle;SR-BI receptor;Structure;subcutaneous;Tertiary Protein Structure;Testing;Time;United States National Institutes of Health;Vascular Endothelial Cell;vascular inflammation;Work

PROJECT_TITLE: A Novel role of Endothelial Breakpoint Cluster Region Protein in Vascular Health and Disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative The proposed research will reveal novel mechanisms underlying the regulation of pre-mRNA splicing in brain development. It will have significant impacts on the field of RNA biology and neurodevelopment. Because pre- mRNA splicing is a fundamental cellular process that is often mis-regulated in human diseases, the molecular mechanisms revealed in this study will have broad implications for translational medicine.

PI_NAMEs: YANG, YANZHONG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Alternative Splicing;Arginine;arginine methyltransferase;autosome;Binding Sites;bioinformatics pipeline;Biological Process;Biology;Brain;Cell Physiology;cell type;cognitive function;conditional knockout;consanguineous family;Data;Development;Electrophysiology (science);empowerment;Enzymes;excitatory neuron;Exons;experimental study;Family;Gene Expression;genome sequencing;Glutamates;Goals;human disease;Human Genome;Impaired cognition;Impairment;Individual;Intellectual functioning disability;Knockout Mice;Learning;Link;loss of function;Mediating;member;Memory;Messenger RNA;Methylation;Methyltransferase;Missense Mutation;Modification;Molecular;mouse model;mRNA Precursor;mRNA Stability;multicatalytic endopeptidase complex;Mus;mutant;Mutation;nanopore;neurodevelopment;Neurodevelopmental Disorder;novel;Pathway interactions;Patients;Post-Translational Protein Processing;posttranscriptional;Process;Protein-Arginine N-Methyltransferase;Proteins;Reader;recruit;Regulation;Regulatory Element;Research;RNA;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;single-cell RNA sequencing;Site;Spliced Genes;Synapses;Synaptic plasticity;Testing;Transcriptional Regulation;translational medicine;U2 Small Nuclear Ribonucleoprotein;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;whole genome;Work

PROJECT_TITLE: Biological function and regulation of PRMT9 in synapse development

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Orphan Drug;Osteoporosis;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Glutamine metabolism provides αKG and glutathione to regulate early and late stages of osteoblast differentiation, although the precise role of these two metabolites during physiological bone formation is not well understood. Data generated by this proposal will: 1) establish the necessity of Glutamate Oxaloacetate Transaminase 2 (GOT2) dependent αKG synthesis, 2) define the contribution of αKG to osteoblast energetics and metabolism, 3) define the regulation of RUNX2 by reactive oxygen species, and 4) establish the therapeutic feasibility of antioxidants to protect RUNX2 and stimulate bone formation patients with cleidocranial dysplasia. Our findings will have broad implications in bone development and the maintenance and regeneration of bone mass.

PI_NAMEs: KARNER, COURTNEY MICHAEL (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Affect;alpha ketoglutarate;American;Amines;Amino Acids;Anabolism;Antioxidants;bone;Bone Development;Bone Formation Stimulation;bone health;bone mass;Bone necrosis;Bone Regeneration;Bone Resorption;Cell Lineage;Cells;Cellular Metabolic Process;Chronic;Citric Acid Cycle;Cleidocranial Dysplasia;conditionally essential amino acid;Data;defined contribution;Disease;efficacy evaluation;Endowment;Environment;Enzymes;Femoral Fractures;Funding;Glutamine;Glutathione;Glycolysis;Health Care Costs;Homeostasis;human model;in vivo;insight;Jaw;Knock-out;Life;Maintenance;Malate-Aspartate Shuttle Pathway;Mediating;Metabolism;metabolomics;Mitochondria;Mitochondrial Aspartate Aminotransferase;mitochondrial membrane;Molecular;mouse genetics;mouse model;Mus;Natural regeneration;new therapeutic target;novel therapeutic intervention;Nucleotides;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporosis;Oxaloacetates;Oxidative Stress;Patients;permissiveness;Pharmaceutical Preparations;Phenotype;Physiological;Production;Proliferating;protein expression;Proteins;Reaction;Reactive Oxygen Species;Regulation;repaired;Risk;Role;Runx2 protein;skeletal;skeletal stem cell;Specific qualifier value;stem cells;Therapeutic;Work

PROJECT_TITLE: Role of Glutamine Metabolism During Osteoblast Differentiation and Bone Formation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Wound Healing and Care

ORG_CITY: CHICAGO

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Information from this project will impact on our understanding of how corneal inflammation and limbal/corneal epithelial differentiation are regulated. Excessive inflammation and aberrant differentiation have been indicated in numerous corneal epithelial diseases and these studies will provide insight into how modulation of selective autophagy-associated signaling may improve such conditions.

PI_NAMEs: PENG, HAN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Alkalies;Anterior;Area;Atlases;Attenuated;attenuation;Autophagocytosis;Autophagosome;Basal Cell;Binding;Blindness;burn model;Cell Differentiation process;Cell Line;Cells;Chemical Burns;conditional knockout;Cornea;Corneal Diseases;corneal epithelium;cytokine release syndrome;Data;Development;Differentiation Antigens;Disease;Down-Regulation;Epithelial Cells;Epithelium;Eye Burns;Eye diseases;eye dryness;gain of function;Gene Expression;Genes;Genetic;Goals;Human;immune cell infiltrate;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;innovation;insight;Invaded;knock-down;Knockout Mice;Knowledge;limbal;loss of function;Macrophage;Mediating;Methodology;Modeling;Molecular;mouse model;Mucins;multicatalytic endopeptidase complex;Mus;new therapeutic target;NF-kappa B;notch protein;novel;overexpression;Pathway interactions;Patients;Physiological;Plasminogen Activator Inhibitor 2;Play;Population;Process;Proliferating;Proteins;receptor;Regulation;Reporting;response;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem;Stratum Basale;Stress;Technology;Testing;Tissues;TRAF2 gene;transcriptome;Translating

PROJECT_TITLE: The Roles of Autophagy in Limbal/Corneal Epithelia

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Immunotherapy;Neurosciences;Women's Health Research

ORG_NAME: WISTAR INSTITUTE

PHR: PROJECT NARRATIVE The brain is one of the common organs for breast cancer recurrence. With rising incidence, breast cancer brain metastasis has become a major problem in clinic. Metastasis is a multi-step process that requires the complex interplay between cancer cells and the stromal cells. In this proposal, we focus on how type I interferon response in astrocytes, the unique stromal cells in the brain microenvironment, facilitates breast cancer brain metastasis. If we define microenvironmental changes during brain metastasis, we can yield real and actionable targets on the brain, instead of on cancer cells, to provide more effective therapies for brain metastasis patients.

PI_NAMEs: CHEN, QING  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;angiogenesis;Animal Model;Astrocytes;Attenuated;Brain;brain cell;cancer cell;cancer recurrence;CCL2 gene;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Cessation of life;chemokine;chemokine receptor;chemotherapy;Chronic;Clinic;Clinical;Coculture Techniques;Combined Modality Therapy;Complex;Data;Development;Disease;Disseminated Malignant Neoplasm;Distal;druggable target;effective therapy;efficacy testing;experimental study;Growth;IFNAR1 gene;Imaging Techniques;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunologics;improved;In Vitro;in vivo;Incidence;Infiltration;inhibitor;insight;Interferon Activation;Interferon Type I;Interferon-beta;Interferons;Invaded;Knockout Mice;Lesion;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Medical;Metastatic malignant neoplasm to brain;metastatic process;Modeling;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;new therapeutic target;notch protein;novel;optimal treatments;Organ;Pathway interactions;Patients;pre-clinical;Pre-Clinical Model;Process;Production;receptor;reconstruction;recruit;Reporter;Research;Research Proposals;response;Sampling;Shapes;side effect;Signal Induction;Signal Transduction;Stromal Cells;Study models;Survival Rate;Systemic Therapy;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Time;transcriptome sequencing;tumor;tumorigenic;type I interferon receptor;Visualization;Work

PROJECT_TITLE: Interrogating Type I Interferon signaling in breast cancer brain metastasis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Despite improvements in overall survival for most cancers, survival for patients with pancreatic cancer remains dismally low. This project aims to address the cellular origin, initiation and progression of pancreatic ductal adenocarcinoma (PDAC) and to identify genes and signals critically involved in this process. Successful completion of this project may provide an opportunity for targeted therapy for this devastating disease.

PI_NAMEs: XU, KELI  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acinar Cell;Address;Adult;Benchmarking;Bioinformatics;biomarker development;biomarker identification;Caerulein;cancer initiation;Cancer Relapse;cancer stem cell;Candidate Disease Gene;Cell Line;cell type;Cells;Characteristics;Clinical;Coculture Techniques;Cre-LoxP;Deceleration;Development;Diagnosis;differential expression;Disease;Disease Progression;DNA Sequence Alteration;Drug resistance;Duct (organ) structure;Ductal Epithelial Cell;Early Intervention;effective intervention;Exhibits;experimental study;Flow Cytometry;Gene Amplification;Gene Expression Profiling;Gene Mutation;Genes;genetic manipulation;Human;improved;Injury;Intervention;KRAS oncogenesis;KRASG12D;Lesion;Ligands;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;Messenger RNA;molecular subtypes;mouse genetics;mouse model;Mutation;neoplastic cell;notch protein;Notch Signaling Pathway;Oncogenic;Organoids;overexpression;Pancreas;pancreas development;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic Intraepithelial Neoplasia;Pathogenesis;Patients;Predisposition;premalignant;Process;progenitor;Regulation;Resistance;response;Role;Signal Transduction;stem;stem cell population;stem-like cell;Structure;System;targeted treatment;Testing;therapeutic target;Tissue-Specific Gene Expression;TP53 gene;transcriptome sequencing;tumor;tumor initiation;tumor progression;tumorigenesis;Up-Regulation

PROJECT_TITLE: Dissecting roles of Lunatic Fringe-dependent Notch signaling in pancreatic cancer

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Bone marrow (BM) mesenchymal stem cells (MSCs) are rare non-hematopoietic perivascular stromal cells which regulate hematopoietic stem cell (HSC) function by secreting high levels of niche factors such as Vascular Cell Adhesion Molecule-1 (VCAM1). While the specific role of MSC-derived VCAM1 on HSC and MSC maintenance remains unknown, our supporting data indicates that MSCs are the BM’s main source of Vcam1 and suggests that VCAM1 is critical for the maintenance, survival, and function of MSCs. Here, we will use rigorous genetic models, and technically innovative experimental approaches to elucidate the mechanisms by which VCAM1 promotes MSC survival and regulates HSC and progenitor function.

PI_NAMEs: DI STAULO, ANNA MARISA (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Adult;Affect;Aging;Binding;Biological Assay;Blocking Antibodies;Blood;Blood Cells;Blood Vessels;bone;Bone Marrow;bone marrow mesenchymal stem cell;Bone Marrow Transplantation;Bone Regeneration;Cartilage;Cell Adhesion Molecules;Cell Count;Cell Cycle;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cell secretion;Cells;Classification;Complex;Confocal Microscopy;CXC Chemokines;Data;Disease;Endothelial Cells;endothelial stem cell;Endothelium;Ensure;Exhibits;ezrin;Fatty acid glycerol esters;Flow Cytometry;Fluorouracil;Frequencies;Genetic Models;genotoxicity;Grouping;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Mobilization;hematopoietic stem cell niche;hematopoietic stem cell quiescence;Hematopoietic stem cells;Homeostasis;Homing;Human;improved;In Vitro;innate immune function;innovation;Integrin alpha4beta1;Integrins;irradiation;Leukemic Cell;Ligands;Maintenance;Mediating;Mesenchymal Stem Cells;microCT;mouse model;Mus;N-Cadherin;novel;Organism;Pathway interactions;peripheral blood;Phenotype;PIK3CG gene;Population;Predisposition;Proliferating;receptor;regeneration potential;Regenerative capacity;Regulation;Role;Sampling;self-renewal;Series;Signal Transduction;single-cell RNA sequencing;Skeletal Development;Skeleton;Source;Spatial Distribution;Spleen;Stains;Stem Cell Factor;stem cell function;stem cell niche;stem cell survival;stem cells;Sternum;Stress;Stromal Cell-Derived Factor 1;Stromal Cells;Structure;Tamoxifen;Testing;transcriptome sequencing;Transgenic Mice;Vascular Cell Adhesion Molecule-1;X-Ray Computed Tomography

PROJECT_TITLE: REGULATION OF BONE MARROW MESENCHYMAL STEM CELLS BY VCAM1


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Coronary artery disease is the leading cause of death in the United States. It manifests itself in the arteries and can lead to myocardial infarction. Understanding the biological networks that underlie the complex interactions in coronary artery disease is required for disease prevention, diagnosis, and treatment.

PI_NAMEs: PERRY, ROBERT NOAH (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Algorithms;Anti-Hypertensive Agents;Arteries;ascending aorta;ATAC-seq;Atherosclerosis;Automobile Driving;Bayesian Network;Binding;Biological;Biological Assay;Biology;biomarker identification;Blood Vessels;Cause of Death;Cell Culture Techniques;cell dedifferentiation;Cell Proliferation;Cell Separation;cell type;Complex;Coronary Arteriosclerosis;Coronary artery;Data;Diagnosis;differential expression;Disease;Disease susceptibility;disorder prevention;disorder risk;Donor person;drug action;Endothelial Cells;experimental study;gain of function;Gene Expression;gene interaction;gene network;Genes;Genetic;Genetic Transcription;genome wide association study;Goals;Heart Transplantation;Heritability;Homeostasis;Human;knock-down;Lentivirus;Link;Lipids;liquid chromatography mass spectrometry;loss of function;Macrophage;Measures;Medial;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;migration;Molecular;monocyte;mortality;multi-ethnic;Myocardial Infarction;network architecture;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;Nitrogen;nitrogen metabolism;NOS3 gene;novel therapeutic intervention;novel therapeutics;osteogenic;overexpression;particle;Pathologic;Pathway Analysis;Pathway interactions;Phenotype;Play;preservation;Process;Production;programs;Proliferating;Recombinants;Regulator Genes;response;Risk;Risk Factors;Role;Series;Signal Pathway;Smooth Muscle Myocytes;statistics;Stimulus;Testing;Time;Transcript;transcription factor;transcriptome sequencing;transdifferentiation;United States;Variant;Vascular Endothelial Growth Factor C;Vascular Smooth Muscle

PROJECT_TITLE: The role of nitrogen metabolism in smooth muscle cell phenotypic plasticity


NIH_SPENDING_CATS: Congenital Structural Anomalies;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Beckwith-Wiedemann syndrome, a fetal overgrowth syndrome with a mortality rate of 21 percent, exhibits an increased prevalence in children conceived by in vitro fertilization, and about 70 percent of cases of Beckwith- Wiedemann syndrome are due to dysregulation of the long non-coding RNA Kcnq1ot1. My project aims to elucidate the mechanism of Kcnq1ot1, and further our understanding of how defects in long non-coding RNA function result in diseases like Beckwith-Wiedemann syndrome. Successful completion of this project will result in a foundation of knowledge that could eventually lead to the optimization of in vitro fertilization and may reveal strategies to attenuate the epigenetic activity of Kcnq1ot1, therapeutically.

PI_NAMEs: MURVIN, MCKENZIE  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Affinity;Alleles;Area;Assisted Reproductive Technology;Attenuated;Beckwith-Wiedemann Syndrome;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biology;career;Chemicals;Child;ChIP-seq;cofactor;Complex;Congenital Abnormality;CRISPR/Cas technology;Data;Death Rate;Defect;Development;Developmental Biology;Disease;DNA;Educational process of instructing;Elements;Enzymes;Epigenetic Process;epigenetic silencing;Exhibits;Fellowship;Fertilization in Vitro;Fetal Macrosomia;Foundations;Future;gene discovery;Gene Silencing;Genes;Genome;Genomic approach;Genomics;Goals;Histones;Human;Immunoprecipitation;in vitro Model;Infertility;Inherited;insight;Institution;Knowledge;Laboratories;Maps;Mediating;Mentors;Mentorship;Modeling;Molecular Biology;Monitor;Mus;Mutation;Nucleotides;oral communication;Placenta;Play;Polycomb;Pre-implantation Embryo Development;Prevalence;Principal Investigator;Protein Binding Domain;Proteins;recruit;Research Personnel;Resolution;Ribonucleoproteins;RNA;RNA Sequences;RNA-Binding Proteins;RNA-Protein Interaction;Role;Science;skills;stillbirth;superresolution microscopy;Syndrome;Therapeutic;Training;training opportunity;Transcript;transcriptome;transcriptome sequencing;trophoblast;trophoblast stem cell;undergraduate student;Untranslated RNA;Visualization;Writing

PROJECT_TITLE: Dissecting mechanisms of gene silencing by the lncRNA Kcnq1ot1 in mouse trophoblast stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Diabetes;Nutrition;Wound Healing and Care

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Diabetes can lead to complications like diabetic foot ulcers, which are nonhealing and may lead to morbidity and death. How small metabolites are utilized in normal wounds and altered in diabetic wounds remains understudied. By investigating metabolite utilization spatiotemporally and by host cells, this study aims to understand how alterations in metabolic usage contribute to delayed wound healing in diabetes.

PI_NAMEs: LE, JOHNNY  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Acceleration;amino acid metabolism;Amino Acids;Amputation;assault;Award;Biochemical;Biochemical Pathway;Biological;Blood;Blood Vessels;building materials;Carbon;Cell Physiology;Cell Separation;cell type;Cells;Cessation of life;chronic ulcer;chronic wound;Citric Acid Cycle;Consumption;Coupled;Critical Pathways;Data;db/db mouse;Development;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;diabetic wound healing;Diet;experimental study;feeding;Financial Hardship;Functional disorder;Future;Genetic;Glycine;Harvest;healing;Histology;Human;Immune;immune function;Immune response;Immunofluorescence Immunologic;Impaired healing;Impaired wound healing;Impairment;improved;in vivo;Individual;Infection;infection risk;innovation;Investigation;Isotopes;Knock-out;Knowledge;liquid chromatography mass spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Microscopy;migration;Modeling;Molecular;Morbidity - disease rate;Mus;muscle progenitor cell;Neurons;Non-Essential Amino Acid;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nucleotide metabolism;Nutrient;Nutritional Requirements;Organ;Pathway interactions;Patients;pharmacologic;Play;Population;Process;Production;Proliferating;Protein Biosynthesis;Quality of life;repaired;Resolution;Risk;Role;Route;Serine;Skin;skin barrier;skin wound;Societies;spatiotemporal;stable isotope;success;Supplementation;Technology;Testing;Time;Tissues;tool;wound;wound care;wound closure;wound environment;wound healing

PROJECT_TITLE: Elucidating the role of nonessential amino acid metabolism in diabetic skin wounds