ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Statement of Relevance: Ozone (O3) is a recognized cause of environmental lung injury and contributes to exacerbations of chronic pulmonary diseases and overall mortality. A critical component of addressing this public health concern must focus on understanding how O3 induces inflammation and how this response is exacerbated by prior respiratory viral infections, such as SARS-CoV2. Here we define the roles of distinct macrophage subsets in the severity and persistence of O3-induced inflammation and explore a potential targeted immune intervention to modulate O3-derived effects on respiratory health.

PI_NAMEs: MISHARIN, ALEXANDER ;TIGHE, ROBERT MATTHEW (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 2019-nCoV;Acute;Address;Alveolar;Alveolar Macrophages;autocrine;cell type;Cells;Chronic lung disease;COVID-19 pandemic;COVID-19 pneumonia;Data;Environmental Exposure;Equilibrium;Exposure to;Growth Factor;Homeostasis;Human;human subject;Immune;Immune Targeting;immunological intervention;Individual;Inflammation;Inflammatory Response;Influenza;influenzavirus;Laboratories;Link;Lung;lung injury;Macrophage;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutic intervention;Ozone;ozone exposure;pathogen exposure;Patients;Performance;Phenotype;Physiological;Pneumonia;Population;Populations at Risk;post SARS-CoV-2 infection;Predisposition;Public Health;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Receptor Signaling;recruit;Reporting;Resolution;respiratory;respiratory health;response;Role;Sampling;seasonal influenza;Seminal;Severities;Signal Transduction;single cell analysis;single cell genomics;Stromal Cells;System;Techniques;Testing;Tissue Expansion;Tissues;transcriptomics;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work

PROJECT_TITLE: Monocyte-derived alveolar macrophage drives inflammatory response to lung ozone exposure

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: INNOVATIVE DESIGN LABS, INC.

ORG_STATE: MN

PHR: Project Narrative Musculoskeletal (MSK) disorders are among the most prevalent chronic conditions, and a leading cause of global disability and pain. Multiple studies have confirmed that medical students lack competency and training opportunities in this domain and therefore have difficulty performing and interpreting the results of MSK physical examinations which can lead to reduced patient outcomes. Inadequate foundational competence in MSK medicine at an early level of training increases the potential for diagnostic and management errors for future physicians.

PI_NAMEs: CONDON, JOHN PAUL (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3D Print;Accounting;Address;Adipose tissue;Adoption;Adult;Affect;Anatomy;Ankle;Arthritis;Articular Range of Motion;Articulation;automated assessment;Bone structure;Case Study;Chronic;Clinical;Collaborations;Competence;Consult;Contracture;cost effective;design;Development;Diagnosis;Diagnostic;disability;Disease;Education;Educational Curriculum;Educational Status;Elasticity;Elbow;Electronics;Engineering;Environment;Evaluation;experience;Faculty;Fatty acid glycerol esters;Feedback;Fright;Future;Health;Health Sciences;Hip region structure;human study;human subject;improved;Injury;innovation;Joints;kinematics;Knee joint;Knowledge;Learning;ligament injury;Ligaments;Manikins;Mechanics;Medical;medical schools;Medical Students;Medicine;Meniscus structure of joint;Methods;Minnesota;Monitor;Muscle;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;Musculoskeletal structure;neglect;Orthopedics;Pain;Pathology;Patient-Focused Outcomes;Patients;Phase;Physical Examination;Physical therapy;Physicians;Prevention;primary care provider;programs;prototype;Residencies;Rotation;Schools;Shoulder;simulation;skeletal;skills;skills training;Skin;soft tissue;Sports;Standardization;Students;success;System;Technology;Tendon structure;Testing;tool;Training;training opportunity;Training Programs;Treatment Cost;United States;Universities;Variant;Vertebral column;Wages;Weight;Wrist

PROJECT_TITLE: Simulation and Education Tool for Physical Examinations of Orthopedic Pathologies


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The emergence of antibiotic-resistant gonorrhea poses an immense threat to public health. Despite successes in identifying the genetic basis of antibiotic resistance, the genes and pathways that modulate the fitness costs incurred by resistance-conferring alleles and thus facilitate the acquisition and maintenance of these resistance determinants remain poorly understood. This proposal will address these gaps by applying a synergistic combination of approaches: identifying new compensatory mutations during competitive co-infections in the mouse model of gonorrhea, application of systematic population genomics-informed methods to identify compensatory mutations in human isolates, and comprehensive experimental analysis to define their mechanisms.

PI_NAMEs: GRAD, YONATAN H (contact);JERSE, ANN E.;NICHOLAS, ROBERT A

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Active Sites;Address;Alleles;Anabolism;Animal Model;Animals;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Back;bacterial fitness;Binding;Biochemical;Biology;candidate identification;Ceftriaxone;Cell Physiology;Ciprofloxacin;Clinical;clinically relevant;co-infection;Coculture Techniques;Collection;Compensation;cost;Data;Dependence;Diagnosis;Diagnostic;Disease;Drug resistance;drug-resistant gonorrhea;Essential Genes;Evolution;Exclusion;experimental analysis;Female;fitness;Genes;Genetic;Genetic Epistasis;Genome;genome sequencing;Genomics;Goals;Gonorrhea;Growth;Guidelines;Human;improved;In Vitro;in vivo;Infection;infection rate;insight;Knowledge;large datasets;Lethal Genes;Link;Maintenance;Mediating;metabolomics;Methods;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Mutation;Neisseria gonorrhoeae;novel strategies;Organism;Pathogenesis;Pathway interactions;Phenotype;Phylogeny;Physiological;Physiology;Population;Predisposition;Prevention;Public Health;quinolone resistance;reproductive tract;Research Personnel;Resistance;resistance allele;resistance mutation;resistant strain;success;surveillance strategy;Testing;Thiamine;transcriptomics;Vaccines;Variant;whole genome

PROJECT_TITLE: Identification and analysis of compensatory mutations that support the evolution of antibiotic resistance in Neisseria gonorrhoeae

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because understanding novel mechanisms by which a biological pathway finetunes metabolism and controls cellular respiration will unveil a new and alternative strategy to treating patients with defects in metabolism and mitochondria diseases. The research proposed aims at understanding the fundamental aspects of the UFM1 post-translational modification (UFMylation) and its undescribed roles in controlling cellular metabolism and mitochondrial function. Thus, the proposed research is relevant to the part of the NIGMS’ mission that pertains to understanding biological processes and laying the foundation for the treatment of metabolic and mitochondrial diseases broadly.

PI_NAMEs: NGUYEN, PHONG THANH (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biological;Biological Process;C-terminal;career;Cell Physiology;Cell Respiration;Cells;Child;Complex;Defect;Disease;Electron Transport;Endoplasmic Reticulum;enzyme activity;Enzymes;Fibroblasts;Foundations;Genetic;Germ-Line Mutation;Glucose;Glycine Hydroxymethyltransferase;Goals;Homeostasis;Human;human disease;Impairment;innovation;Isotope Labeling;Isotopes;Link;loss of function;Measures;Mediating;Metabolic Diseases;Metabolic Pathway;metabolic rate;Metabolism;metabolomics;Mission;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Proteins;Modification;Molecular;Molecular Mechanisms of Action;N-terminal;National Institute of General Medical Sciences;Neurodevelopmental Disability;Neurodevelopmental Disorder;novel;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Oxidative Phosphorylation;Oxidative Phosphorylation Deficiency;Pathway interactions;Patients;Post-Translational Protein Processing;Process;Protein Biosynthesis;protein complex;protein function;Proteins;Public Health;Reaction;Reporting;Research;Research Personnel;Respiration;respiratory;Ribosomes;Role;Serine;skeletal disorder;skills;Structure;Testing;Time;Ubiquitin;Ubiquitination;Variant;Work

PROJECT_TITLE: The roles of the UFM1 post-translational modification in cellular metabolism


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Back Pain;Bioengineering;Biotechnology;Chronic Pain;Genetics;Nanotechnology;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Degenerative disc disease (DDD) is a major source of low back pain that represents a tremendous financial burden to the public health. This project will develop a novel, minimal-invasive approach for the treatment of DDD that relies on enhancing the regenerative and anti-inflammatory capacity of extracellular vesicles (EV) derived from mesenchymal stem cells using state-of-the-art gene editing technology. Successful completion of this study will guide future development of EV-based therapy not only for DDD, but for example also for osteoarthritis in the hands, neck, knees, and hips, which could benefit millions of people in the United States every year.

PI_NAMEs: WUERTZ-KOZAK, KARIN  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adipose tissue;Affect;alternative treatment;Anti-Inflammatory Agents;Antiinflammatory Effect;autocrine;Back Pain;Biological;Biological Assay;Biotechnology;Catabolism;cell behavior;Cell Line;Cell Physiology;Cell surface;Cell Survival;Cell Therapy;Cells;Chemistry;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;combat;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;cytokine;Data;Degenerative polyarthritis;Development;Direct Costs;Disease;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;exosome;Exploratory/Developmental Grant;Exposure to;extracellular vesicles;Financial Hardship;Future;gene editing technology;Gene Expression Profiling;Genes;Genetic;Genome engineering;Glucose;Goals;Hand;high risk;Hip region structure;Human;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Intervertebral disc structure;intervertebral disk degeneration;invention;Knee;Low Back Pain;Mediator;Membrane;Membrane Lipids;Mesenchymal Stem Cells;Methods;microvesicles;minimally invasive;Minor;Modification;nanocarrier;nanoparticle;Natural regeneration;Nature;Neck;Neck Pain;Nerve;non-opioid analgesic;novel;novel therapeutics;nucleus pulposus;Osmolar Concentration;Outcome;overexpression;Pain;Pain management;particle;Pathology;patient population;Patients;Persons;Play;Process;Production;Property;protein expression;Proteins;Proteomics;Public Health;Publishing;regenerative;Regenerative capacity;Reproducibility;Research;Research Personnel;Role;Societies;Source;stem cell therapy;stem cells;success;Surface;Testing;Therapeutic;Therapeutic Effect;Tissues;TNF gene;transcription factor;transcriptomics;Transmission Electron Microscopy;treatment strategy;Ultracentrifugation;United States;uptake;vesicular release;Western Blotting;Work

PROJECT_TITLE: Extracellular vesicles produced by CRISPR-activated MSCs: A potential therapy for degenerative disc disease

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Diabetes;Genetics;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative When the decrease in insulin sensitivity during pregnancy is excessive, it results in poor pregnancy outcomes such as gestational diabetes. We hypothesized that the placenta expresses and releases small molecules called microRNA that act on the placenta and other maternal tissues such as muscle, liver, and adipose tissues to impact insulin sensitivity. Our studies will help to understand how microRNA from the placenta regulate insulin sensitivity in pregnancy.

PI_NAMEs: HIVERT, MARIE-FRANCE ;O'TIERNEY-GINN, PERRIE F (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;adverse pregnancy outcome;candidate selection;Cell model;Chromosome 19;circulating microRNA;Circulation;cohort;Data;Development;Diabetes Mellitus;DNA Methylation;early pregnancy;Endocrine;Endocrinology;Epigenetic Process;experimental study;Exposure to;Fatty Acids;fetal;Fetal Growth;Fetal Macrosomia;First Pregnancy Trimester;Functional disorder;Gene Expression;gene function;Genes;genome wide association study;Gestational Diabetes;Glucose;glucose metabolism;Glucose tolerance test;glucose uptake;Goals;Hepatocyte;Hour;Human;Hyperglycemia;Hypoglycemia;improved;In Vitro;indexing;Insulin;insulin regulation;insulin sensitivity;insulin signaling;interest;Intervention;Late pregnancy;Leptin;Liver;maternal hyperglycemia;Measures;member;Metabolic;MicroRNAs;Modeling;Mothers;Muscle;Muscle Cells;Muscle Fibers;novel;novel therapeutics;Nutrient;Nutrient availability;offspring;OGTT;Oral;paracrine;Pathway interactions;Perinatal;Peripheral;Phenotype;Physiological;Physiological Adaptation;Physiology;Placenta;Placental Biology;Placental Function Tests;Plasma;Play;Pregnancy;Pregnancy Outcome;Production;prospective;Prospective cohort;Proteins;Regulation;response;Risk;Role;Sampling;Second Pregnancy Trimester;Site;small molecule;Somatomedins;Testing;Therapeutic Agents;Third Pregnancy Trimester;Time;Tissues;uptake;Woman

PROJECT_TITLE: Placental miRNAs paracrine and endocrine roles in insulin sensitivity in pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The metabotropic glutamate receptor (mGluR) family are G protein coupled receptors that are activated by the neurotransmitter glutamate and function as dimers. To date, there has been no efficient strategy by which pure populations of mGluR heterodimers can be expressed in isolation so that the effects of pharmacological tools can be tested. The proposed project will utilize a novel composition control method for generating pure populations of mGluR dimers, then utilize this system to generate an mGluR compound vs. dimer activity atlas from which we hope to gain a better understanding of mGluR physiology and more targeted therapeutics.

PI_NAMEs: KAMMERMEIER, PAUL J. (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Agonist;Amino Acid Sequence;antagonist;Atlases;Biological Assay;Brain;Cataloging;Cell membrane;Cells;Chimera organism;Cicatrix;Clinic;Complement;Data;design;dimer;druggable target;Electrophysiology (science);Exhibits;Family;Family member;Fluorescence Resonance Energy Transfer;fluorophore;G-Protein-Coupled Receptors;Glutamates;Goals;GTP-Binding Proteins;Heterodimerization;Homo;improved;intein;interest;Ion Channel;Label;Length;Ligands;Link;Measurement;Measures;Membrane Proteins;metabotropic glutamate receptor 2;metabotropic glutamate receptor 4;Metabotropic Glutamate Receptors;Methods;Molecular Conformation;Mutagens;Neurons;Neurotransmitters;novel;patch clamp;Pathology;pharmacologic;Pharmacology;Physiology;Population;Positioning Attribute;pre-clinical;Probability;receptor;receptor expression;receptor function;recruit;response;retention rate;RNA Splicing;Signal Transduction;Surface;System;Tail;targeted treatment;Testing;Therapeutic;Titrations;tool;Work

PROJECT_TITLE: A novel system for controlling dimeric receptor composition to discover unique heterodimer pharmacology

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance to Public Health Meiosis, a specialized cell division that generates sex cells such as sperm and eggs, is essential for the inheritance of genomes from parent to offspring. Errors in this process lead to the production of cells with an abnormal number of chromosomes or aneuploidy, and this is a major cause of miscarriages and birth defects such as Down syndrome. Our findings from this study will elucidate the molecular mechanisms underlying chromosome inheritance during meiosis and will also have general impact in the fields of cell cycle regulation and cancer.

PI_NAMEs: KIM, YUMI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affinity;Aneuploidy;Behavior;Biochemical;Caenorhabditis elegans;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;chromosome number abnormality;Chromosome Pairing;Chromosome Segregation;Chromosomes;Code;Congenital Abnormality;Cytology;Down's Syndrome;egg;Eukaryota;Fertilization;Foundations;Genetic;Genetic Crossing Over;genetic information;Genetic study;Genome;Germ Cells;Germ Lines;Haploidy;Homologous Gene;Human;Individual;Lead;Light;Malignant Neoplasms;Maps;Mediating;Meiosis;Meiotic Recombination;Molecular;novel;offspring;Organism;Parents;Phosphoric Monoester Hydrolases;Phosphorylation Site;Phosphotransferases;Play;Positioning Attribute;Process;Production;programs;Property;Prophase;protein complex;protein protein interaction;Proteins;Protocols documentation;Public Health;Research;response;Role;scaffold;Signal Transduction;sperm cell;Spontaneous abortion;stoichiometry;Structure;Synapses;Synaptonemal Complex;Syp protein;transmission process;Work;zygote

PROJECT_TITLE: Molecular Control of Meiotic Chromosome Dynamics

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: There is a critical need for identifying molecular mechanisms underlying remyelination failure in multiple sclerosis, the most common demyelinating disorder with no therapies directly targeting myelin repair. The proposed research is relevant to public health because understanding the function and molecular mechanisms of PARP1 in oligodendrocyte myelin formation provides new insights into devising new strategies for myelin repair. Thus, this proposal is in line with the NIH's mission – uncovering new knowledge of PARP1 in myelin formation and repair which will potentially lead to novel remyelination-promoting therapies for demyelinating disorders.

PI_NAMEs: GUO, FUZHENG  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Address;Affect;Animal Model;Anti-Inflammatory Agents;Antibodies;Area;Biology;Brain;Cancer Biology;cancer cell;Cell Death;Cell Lineage;Cell Nucleus;Cells;Central Nervous System;central nervous system demyelinating disorder;Clinical;Curiosities;Data;Demyelinating Diseases;Demyelinations;Detection;DNA Repair;Enzymes;Failure;Family;Family member;Foundations;gain of function;Gene Expression;Genetic;genetic approach;genetic manipulation;Genome Stability;Glycoside Hydrolases;Goals;Histones;Immune;Immunosuppressive Agents;Impairment;In Vitro;in vivo;Inflammation;inhibitor;insight;Knowledge;Laboratories;Lesion;loss of function;Mediating;member;Methodology;Mission;Modality;Modeling;Molecular;Molecular Target;Multiple Sclerosis;Multiple Sclerosis Lesions;Myelin;myelination;Neurologic;novel;Nuclear Protein;oligodendrocyte progenitor;Oligodendroglia;Outcome;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phenocopy;Play;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;Polymerase;pre-clinical;prevent;Process;Proteins;Public Health;remyelination;repaired;Research;Role;Sagittaria;Signal Transduction;Spinal Cord;stem cell differentiation;stem cells;Testing;Therapeutic;Transgenic Model;United States National Institutes of Health

PROJECT_TITLE: The curious case of PARP1 in CNS myelin formation and repair

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The proposed research is relevant to public health because the GGGGCC hexanucleotide repeat expansion in the C9orf72 locus is the most common cause of amyotrophic lateral sclerosis (ALS) and the related neurodegenerative disorder, frontotemporal dementia (FTD). We propose to apply our DNA methylation editing tools to study the epigenetic mechanisms contributing to the pathogenesis of C9orf72 ALS/FTD. Precise editing of C9orf72 methylation will establish the functional role of these epigenetic events in the pathogenesis of C9orf72 ALS/FTD and demonstrate the therapeutic potential that editing methylation may have for the most commonly known cause of ALS/FTD.

PI_NAMEs: LIU, X. SHAWN (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: 5' Untranslated Regions;Acceleration;Address;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Bacterial Artificial Chromosomes;Biological Assay;Brain region;C9ORF72;candidate validation;Cells;CGG repeat;CGG repeat expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CpG Islands;Defect;delivery vehicle;demethylation;Development;Diagnosis;Dipeptides;Disease;disease phenotype;Disease Progression;DNA Methylation;DNA methylation profiling;DNMT3a;effective therapy;efficacy evaluation;Electrophysiology (science);Enzymes;Epigenetic Process;epigenetic silencing;Etiology;Event;experimental study;Fibroblasts;FMR1 gene;Fragile X Syndrome;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;gain of function;Genetic;Genetic Transcription;Genome;Human;Hypermethylation;in vivo;induced pluripotent stem cell;loss of function;Methylation;methylome;Molecular;Motor;Motor Neurons;mouse model;multi-electrode arrays;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Onset of illness;Pathogenesis;Pathologic;Patients;Phenotype;Play;Prefrontal Cortex;Production;promoter;Property;protective factors;Protein Isoforms;Proteins;Public Health;Research;Resolution;Risk;RNA;RNA-Binding Proteins;Role;Safety;Sampling;Signal Transduction;Signs and Symptoms;Skin;Testing;Therapeutic;tool;Transcript;transcriptome;transcriptome sequencing;Transgenic Mice;Twin Studies;Variant;Viral Vector;Work

PROJECT_TITLE: Epigenetic Mechanisms Contributing to the Pathogenesis of ALS/FTD with GGGGCC Repeat Expansion Mutation at the C9orf72 Locus

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Mental Health;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Individuals who have insomnia with short sleep duration (ISS) differ from individuals who have insomnia with normal sleep duration (INS) in terms of health risks and treatment response. This study will examine whether patients with ISS and INS demonstrate a differential response to two common insomnia treatments, cognitive- behavioral treatment of insomnia (CBT-I) and trazodone. Our findings could lead to evidence-based treatment guidelines that help clinicians more effectively match treatments to insomnia patients and reduce associated health problems.

PI_NAMEs: KING, WENDY C;WISNIEWSKI, STEPHEN R (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: actigraphy;Adult;Age;base;blind;Blood Pressure;blood pressure elevation;blood pressure reduction;cardiovascular disorder risk;Cardiovascular system;Characteristics;Classification;Clinical;clinical phenotype;clinical practice;clinical research site;Clinical Trials;Cognitive Therapy;cohort;Cohort Studies;Collaborations;Communication;comparative efficacy;Data;Data Coordinating Center;data management;data sharing;Decision Making;Disease;Disease remission;Double-Blind Method;Down-Regulation;Drug Prescriptions;efficacy evaluation;Electrocardiogram;Ensure;Evidence based treatment;Functional disorder;Funding;Genetic;Goals;Guidelines;Health;Health Care Costs;Home Blood Pressure Monitoring;Hydrocortisone;Hypertension;hypothalamic-pituitary-adrenal axis;Impairment;improved;indexing;Individual;Knowledge;Laboratories;Measures;Mediating;Mental Health;Metabolic;Monitor;Occupational Health;off-label use;Outcome;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Placebo Control;Placebos;Polysomnography;post intervention;precision medicine;predicting response;Preparation;primary outcome;Process;protocol development;Protocols documentation;Publications;Quebec;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Research Design;Research Personnel;response;Risk;Salivary;Sampling;secondary outcome;Severities;sex;side effect;Site;Sleep;Sleeplessness;Statistical Data Interpretation;Symptoms;Testing;Time;Training;Trazodone;treatment effect;treatment guidelines;treatment response;United States National Institutes of Health;Validity and Reliability

PROJECT_TITLE: 2/2 Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Phenotypes Based on Objective Sleep Duration: A Sequential Cohort/Randomized Controlled Trial


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Bleeding into the heart muscles (myocardium), termed myocardial hemorrhage, is a side-effect of standardized interventions to re-establish blood flow to the heart; myocardial hemorrhage occurs in 50% of acute myocardial infarction and contributes to heart failure complications. This bleeding, however, cannot be easily detected in the acute setting by existing imaging technology; in essence, we cannot treat what we are unable to diagnose and monitor. Successful development of a reliable, quantitative cardiac magnetic resonance imaging technique to spatially track acute myocardial bleeding and creation of a patient-adaptive disease model based on structure-function relationships will provide a new path for tailoring therapy and improving heart failure outcomes.

PI_NAMEs: NGUYEN, KIM-LIEN T (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acceleration;Acute;Acute myocardial infarction;Adverse effects;adverse outcome;Arrhythmia;Biodegradation;Biological Markers;Blood;Blood capillaries;Blood flow;Blood Vessels;Breathing;Cardiac;cardiac magnetic resonance imaging;Cardiovascular system;Caring;Cause of Death;Cells;Characteristics;Clinical;Compensation;Coronary;Data;Detection;Development;Diagnosis;Diagnostic;disability;disease model;Endowment;Erythrocytes;Evolution;Extravasation;ferumoxytol;Foundations;generative adversarial network;Heart;Heart failure;heart function;Hemoglobin;Hemorrhage;Heterogeneity;Histology;Histopathology;Hospitalization;Hour;Image;image guided;image reconstruction;imaging biomarker;imaging detection;imaging modality;Imaging Techniques;Imaging technology;Immune;improved;indexing;individualized medicine;Infarction;innovation;Intervention;Intravenous;Iron;Left Ventricular Ejection Fraction;Left Ventricular Remodeling;Magnetic Resonance;Maps;Methods;Modality;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;multidimensional data;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial Reperfusion;Myocardial tissue;Myocardium;Outcome;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;porcine model;predictive modeling;Predictive Value;Prognostic Marker;prognostic value;Protocols documentation;Reperfusion Therapy;Resolution;respiratory;risk prediction;risk stratification;Safety;Sampling;Scanning;Secondary to;Sensitivity and Specificity;Severities;side effect;Signal Transduction;Slice;societal costs;spatiotemporal;Specificity;Standardization;Structure;Structure-Activity Relationship;T2 weighted imaging;Techniques;temporal measurement;Testing;Therapeutic;therapeutic target;Time;Tracer;Training;vascular injury;Work

PROJECT_TITLE: Cardiac MRI for Reperfusion Spatial Mapping to Improve Heart Failure Outcomes

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Clinical Research;Complementary and Integrative Health;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The proposed research is relevant to public health because it evaluates the potential of human musicality – a universal and highly variable trait in the general population – as a protective factor against the inevitable rapid decline in hearing health as people age. Findings from this study will establish necessary groundwork for eventually identifying individuals’ risk and resilience profiles for age-related hearing loss based on their musicality – including aptitude, engagement, and genetic predispositions. This project is therefore relevant to the NIH’s mission to gain insights into the nature and behavior of living systems and to apply this knowledge to reduce illness and disability.

PI_NAMEs: NAYAK, SRISHTI  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Age;age group;aged;Aptitude;Architecture;Auditory;auditory processing;Behavior;biobank;Biological;Biological Process;Biology;Clinical;Cochlea;cochlear development;cohort;Communication;Data;Dementia;Detection;disability;Ear;Epidemiology;executive function;Exposure to;Foundations;Frequencies;Future;General Population;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genomic approach;Genomics;Genotype;Health;Hearing;hearing impairment;Heritability;Human;Human Genetics;Impaired cognition;improved;Individual;Individual Differences;individualized prevention;innovation;insight;Knowledge;Labyrinth;life span;Link;Loudness;Maps;Measures;Mental Depression;middle age;Mission;Music;musician;National Institute on Deafness and Other Communication Disorders;Nature;neural;Neurocognitive;novel;older adult;Organism;Outcome;personalized care;Persons;Phenotype;Population;precision medicine;Predisposition;preference;Presbycusis;protective factors;Public Health;Regulation;Research;resilience;Review Literature;Risk;Risk Factors;Role;Sampling;Shapes;skills;social health determinants;Social isolation;Speech;Speech Perception;speech processing;speech recognition;Techniques;Testing;theories;Training;trait;United States;United States National Institutes of Health;Variant;Work;young adult

PROJECT_TITLE: The Musicality, Hearing and Genetics ("MyHearingG") Project:  Experimental, epidemiological, and genomics techniques to explore the role of musicality in hearing health

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative During human development and in adult tissues undergoing repair, stem cells combine, or ‘integrate’, information from a number of extracellular signaling cues to decide what cell types they should become. This proposal seeks to understand how signaling information is integrated within the cell by a set of interconnected genes, called bHLH transcription factors, using experiments in mouse neural stem cells and zebrafish embryos. Insights gained through this work could help improve the generation of desired cell types for tissue engineering and provide new opportunities to remedy errors in signal integration that lead to developmental disorders or cancers.

PI_NAMEs: NANDAGOPAL, NAGARAJAN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;Adult;Affect;Affinity;Animals;Astrocytes;Auxins;Behavior;BHLH Protein;Bioinformatics;cell type;Cells;Collaborations;Complex;Consultations;Cues;Decision Making;design;Development;developmental disease;dimer;Dimerization;Disease;Elements;Embryo;Enabling Factors;Endowment;Environment;experimental study;extracellular;Fibroblast Growth Factor;fluorescence imaging;Generations;Genes;Genetic Transcription;Goals;Helix-Turn-Helix Motifs;Human Development;Image;improved;In Vitro;in vivo;Individual;insight;Investigation;knockout gene;Knowledge;LIF gene;Link;Malignant Neoplasms;Measurement;Measures;Mediating;Mentors;Mentorship;Microscopy;Monitor;Multipotent Stem Cells;Mus;mutant;nerve stem cell;neural;neural plate;neurodevelopment;Neurons;novel;Oligodendroglia;Outcome;Pathologic;Phase;Physiological;Play;Postdoctoral Fellow;Process;programs;Protein Analysis;Proteins;Reagent;repaired;Reporter;response;RNA;Role;Signal Pathway;signal processing;Signal Transduction;Spinal Cord;stem cells;synthetic biology;System;Techniques;Testing;Therapeutic;Tissue Engineering;Tissues;WNT Signaling Pathway;Work;Yeasts;Zebrafish

PROJECT_TITLE: Investigating how bHLH circuits integrate signals for cell fate decisions


NIH_SPENDING_CATS: Clinical Research;Neurosciences

PHR: Public health relevance The past decades have seen dramatic increases in the prevalence of allergic diseases, however, our understanding of what drive these aberrant lung inflammatory responses is limited. We have identified a new subset of macrophages that explicitly drive aberrant allergic responses. The long-term goal of this project is the development of novel therapies that directly address the pathogenesis of patients with allergic airway diseases, underserved by current treatment modalities.

PI_NAMEs: LAJOIE, STEPHANE  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;Afferent Neurons;Allergens;Allergic;allergic airway disease;allergic airway inflammation;Allergic Disease;Allergic inflammation;allergic response;Antigen Presentation;arginase;Automobile Driving;Bioenergetics;cell type;Cells;comparison control;cytokine;Data;Dendritic Cells;Development;eosinophil;Exposure to;Frequencies;Ganglia;Genes;Genetic;genetic approach;Glucose;glucose metabolism;Glycolysis;Goals;Human;Hypersensitivity;IgE;Immunity;Impairment;In Vitro;in vivo;Inflammation;Inflammatory Response;Interleukin-13;interstitial;ITGAX gene;Knockout Mice;Ligands;Lung;Macrophage;Macrophage-1 Antigen;Mediating;Metabolic;metabolic profile;Modality;Molecular;monocyte;Mus;Myeloid Cells;Nasal Polyps;nerve supply;Neurons;Neuropeptide Receptor;Neuropeptides;neurotransmission;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Phenotype;Population;Prevalence;programs;PROKR1 gene;public health relevance;Pulmonary Inflammation;Pyroglyphidae;receptor;Regulation;response;Role;selective expression;Signal Transduction;single-cell RNA sequencing;Source;T-Lymphocyte;Testing;Th2 Cells;Time;Tissues

PROJECT_TITLE: Neuronally-driven accumulation of glycolytic MafB+MHCIIhi IMs drive airway allergy


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Resilience of blood pressure is the ability of the circulatory system to anticipate, resist, absorb, adapt and recover in response to stressors. Emerging data indicate that our blood pressure fluctuates daily as we go about our daily activities and these blood pressure responses affect our health, including our memory. In this project, we will study blood pressure responses to common daily stressors (mental activity, standing and walking) to clarify if resilience of blood pressure (‘bouncing back’ after stimuli) affects our health, especially heart disease, brain health and cognition.

PI_NAMEs: RAMACHANDRAN, VASAN S (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: absorption;Adult;adverse outcome;Affect;Age;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;arterial stiffness;Atherosclerosis;Back;Blood Pressure;Blood Vessels;Brain;brain health;Brain imaging;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Clinical;Cognition;Cognitive aging;cohort;Cohort Studies;Communities;Data;Devices;Diabetes Mellitus;Disease;Dyslipidemias;Early Diagnosis;endophenotype;Enrollment;Epidemiology;Event;Exercise;Family;Formulation;Funding;Future;Generations;Health;Health Transition;Heart;Heart Diseases;Heart Rate;hemodynamics;Heritability;high dimensionality;Homeostasis;Hour;Human;Hypertension;Impaired cognition;Impairment;indexing;Injury;Isometric Exercise;Isotonic Exercise;Kidney;Left Ventricular Hypertrophy;Life course epidemiology;Machine Learning;Magnetic Resonance Imaging;Measures;Memory;men;Microalbuminuria;middle age;mild cognitive impairment;Minority;Modification;MRI Scans;Neurocognitive;neurocognitive test;neuroimaging;normal aging;Obesity;Older Population;Organ;Orthostasis;Outcome;outcome prediction;Participant;pathological aging;Pattern;Perfusion;Peripheral;Pharmaceutical Preparations;Phase;Phenotype;Physiologic Monitoring;Positioning Attribute;Positron-Emission Tomography;Postural adjustments;pre-clinical;predictive tools;prodromal Alzheimer's disease;Prognosis;Property;Psyche structure;Race;rate of change;Recovery;Reflex action;Renal function;resilience;resilience biomarker;response;Rest;Risk;Risk Assessment;Risk Factors;Sample Size;sex;Smoking;Standardization;Stimulus;Stress;stressor;Stroke;Testing;trait;Validation;vascular risk factor;Walking

PROJECT_TITLE: Epidemiology of blood pressure responses to perturbations: Correlates and prognosis for vascular risk, end-organ damage, cognitive aging and preclinical Alzheimer's disease

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative Older sexual minority men (e.g., gay and bisexual men; OSMM) are the only age bracket of SMM experiencing an increase (rather than plateau or decrease) of new HIV diagnoses in the U.S.; yet research addressing factors perpetuating this disparity is lacking.1 This dissertation study integrates three complementary theories - syndemic2, minority stress3,4, and intersectionality5 – and utilizes innovative statistical techniques to explore whether a unique set of age-related psychosocial factors (e.g., age-related discrimination, internalized ageism, aging anxiety, sexual minority specific aging concerns, social isolation, economic marginalization, and perceived cognitive impairment) interact synergistically to exacerbate HIV risk and reduce quality of life, above and beyond traditional syndemic conditions (e.g., substance use) among OSMM living in Florida, a state with one of the highest HIV incidence rates in the nation.6 Findings from this study will not only further NIH and U.S. Ending the HIV Epidemic priorities for HIV/AIDS research7,8, but also catapult an emerging investigator’s programmatic research in behavioral health and health disparities among OSMM, a marginalized, intersectionally invisible population.9,10

PI_NAMEs: WEINSTEIN, ELLIOTT ROYAL (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Adherence;Affect;Age;age effect;age related;aged;Ageism;Aging;AIDS prevention;Anxiety;Behavior;Behavior Therapy;behavioral health;Bisexual;Buffers;career;Child Sexual Abuse;comorbidity;Complex;condomless anal sex;Data;Development;Discrimination;Disease;Disparity;Economics;Enrollment;Epidemic;ethnic diversity;experience;Face;Florida;Fostering;Frequencies;Future;Gays;Glean;Health;Health behavior;health disparity;Heterosexuals;High Prevalence;HIV;HIV diagnosis;HIV disparities;HIV risk;HIV Seronegativity;HIV/AIDS;Impaired cognition;improved;Incidence;indexing;Individual;Inequality;Influentials;innovation;insight;intersectionality;intimate partner violence;Link;Literature;Machine Learning;marginalization;marginalized population;Marriage;Medical;men;Mental Depression;Mental Health;Methodology;Methods;Minority;Minority Groups;Minority Status;minority stress;Modeling;Morbidity - disease rate;National Institute of Drug Abuse;novel;older adult;Older Population;Outcome;pandemic disease;Pattern;peer;physical conditioning;poor health outcome;Population;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;prevention service;programs;protective effect;psychologic;psychosocial;Psychosocial Factor;Quality of life;racial diversity;reduced substance use;Research;Research Personnel;resilience;Role;Severities;sex;sexual minority;sexual minority group;sexual minority men;Site;social exclusion;Social isolation;sociocultural determinant;stressor;Subgroup;substance use;syndemic;System;Techniques;Testing;theories;Trauma;Trees;United States National Institutes of Health

PROJECT_TITLE: Exploring the Role of Novel Aging-Focused Syndemic Conditions on HIV Risk and Quality of Life among HIV-Negative Older Sexual Minority Men


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Regulation of spiny excitatory synapses by Rho-GEFs is crucial for brain development and in neurodevelopmental disorders. Here we will investigate the role of the kalirin/Trio->Rac1->Pak axis in basal brain function and in preclinical models of NDDs characterized by excessive synaptic connectivity. We will also test whether inhibition of this pathway can reverse deficits in mouse models relevant for NDDs.

PI_NAMEs: BARBOLINA, MARIA V.;PENZES, PETER  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: 16p11.2;Affect;autism spectrum disorder;Award;Behavior;Behavioral;behavioral phenotyping;Binding;Biological;Biological Process;Biology;Brain;Cells;Chemicals;Copy Number Polymorphism;Data;Dendritic Spines;Development;Disease;Electrophysiology (science);Epilepsy;Equilibrium;Excitatory Synapse;Experimental Designs;Fragile X Syndrome;Functional disorder;Funding;gain of function mutation;Genes;Genetic;Goals;Grant;Guanine Nucleotide Exchange Factors;improved;in vitro activity;in vivo;inhibitor;Intellectual functioning disability;kinase inhibitor;Knowledge;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;National Institute of Mental Health;Neurobiology;Neurodevelopmental Disorder;neuronal circuitry;Neurons;neurotransmission;novel;p21 activated kinase;paralogous gene;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Pre-Clinical Model;Proteins;Publishing;Regulation;Research;rho;rho GTP-Binding Proteins;Role;Signal Transduction;small molecule;Synapses;synaptogenesis;Testing;therapeutic target;tool;Toxic effect;Vertebral column;Wild Type Mouse

PROJECT_TITLE: Rac-GEF signaling in dendritic spines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Lung

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Asthma is a chronic disease of the lungs, which has been on the rise in recent decades. Our studies strongly suggest that autophagy play a central role in induction of allergic inflammation. Studies in this proposal aim to elucidate the autophagy pathways in the lungs. The identification of autophagy specific inducers may lead to the development of novel, effective therapies for the treatment of this ever-increasing disease.

PI_NAMEs: AKBARI, OMID  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Ablation;adaptive immune response;Affect;Aging;airway hyperresponsiveness;Allergens;Allergic;Allergic Disease;Allergic inflammation;Animal Model;Animals;Antigen-Presenting Cells;Antigens;Asthma;asthmatic patient;Autophagocytosis;Biopsy;Bronchoalveolar Lavage Fluid;CD11c Antigens;Cell Physiology;Cell surface;Cells;Childhood Asthma;Chronic;Chronic Disease;Clinical;clinical translation;Clinical Trials;cohort;Collaborations;Complement;conditional knockout;cytokine;Data;Dendritic Cells;design;Development;Disease;effective therapy;Effector Cell;Ensure;experience;experimental study;Extrinsic asthma;FOXP3 gene;Functional disorder;Generations;Genes;Genetic;genetic manipulation;genetic variant;genome wide association study;Goals;Human;Hypersensitivity;Immune;Immune response;Impairment;improved;In Vitro;Inflammation;Innate Immune Response;insight;Interleukin-1;Interleukin-10;ITGAX gene;Laboratories;Left;Leukocytes;Light;Link;Liquid substance;Lung;Lung Diseases;Lysosomes;Malignant Neoplasms;Measures;Modeling;mouse model;Mus;Nerve Degeneration;neutrophil;new technology;novel;novel strategies;Organelles;Organism;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Play;Population;pre-clinical;Pre-Clinical Model;Process;Production;Proteins;Protocols documentation;Publications;Publishing;pulmonary function;Pulmonary Inflammation;Pulmonology;Pyroglyphidae;Regulatory Pathway;Regulatory T-Lymphocyte;repository;Resolution;Role;Sampling;Science;Scientist;Severities;single-cell RNA sequencing;Steroid Resistance;System;T-Lymphocyte;Technology;Testing;Therapeutic Effect;Therapeutic Uses;Time;Tissues;transcription factor;Transgenic Mice;Translating;translational approach

PROJECT_TITLE: Study the link of autophagy dysfunction to allergic and neutrophilic asthma onset


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Sudden cardiac death (SCD) is a leading cause of death in the United States and those patients who do not meet diagnostic syndromic criteria to explain the etiology of their SCD event are labeled as having Idiopathic Ventricular Fibrillation (IVF). IVF patients lack morphologic, genetic, or ECG biomarkers to risk stratify and determine treatment, making clinical management haphazard causing high morbidity and mortality. We propose to integrate a comprehensive functional and multiomic analysis of IVF patient-specific induced pluripotent stem cells with advanced computational modeling to unravel the pathophysiology of IVF and create a pathway for mechanistic-based treatment to make deliverable gains in arrhythmia prevention.

PI_NAMEs: ECKHARDT, LEE LOCHBAUM (contact);GRANDI, ELEONORA

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adult;Algorithms;Anti-Arrhythmia Agents;Arrhythmia;Biological Markers;Biological Models;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cause of Death;Cells;cellular targeting;Clinical;Clinical Management;Clinical Practice Guideline;Coculture Techniques;cohort;Collaborations;Complex;Computer Analysis;Computer Models;Cues;Data;data integration;Data Set;design;Diagnosis;Diagnostic;diagnostic criteria;Disease;druggable target;Electrocardiogram;Electrophysiology (science);Etiology;Event;Exclusion;Exhibits;experimental study;Fibroblasts;Functional disorder;Gene Expression;Gene Expression Profile;Genetic;genetic architecture;genetic linkage;genetic variant;genome sequencing;Genotype;Goals;hazard;Heart;Heart Diseases;in silico;in vivo;Individual;induced pluripotent stem cell;ineffective therapies;innovation;insight;Intervention;Ion Channel;Knowledge;Label;Maps;Modeling;Morbidity - disease rate;Morphology;mortality;multiple omics;Muscle Cells;Myofibrils;nanoscale;new therapeutic target;Optics;optimal treatments;Output;Pathologic;Pathway interactions;Patients;Pattern;Pharmacology;Phenotype;Population;Post-Translational Protein Processing;predicting response;Prevention;protein expression;Proteomics;Purkinje Cells;recruit;Regulation;risk stratification;Signal Transduction;Structure;sudden cardiac death;Syndrome;System;targeted treatment;Testing;therapeutic target;Tissues;Transcript;transcription factor;transcriptome;Translating;United States;Use Effectiveness;variant of unknown significance;Ventricular;Ventricular Fibrillation;Ventricular Premature Complexes;whole genome

PROJECT_TITLE: Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VF

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MILWAUKEE

ORG_NAME: CLEMENT J. ZABLOCKI VA MEDICAL CENTER

PHR: Calcium pyrophosphate deposition disease (CPDD) is a painful form of arthritis which is common among US veterans. Risk factors for CPDD include advanced age, and prior joint trauma which are common characteristics of the veteran population. Its cause is currently unknown and there are no specific or effective therapies for this painful arthritis. This work explores the role of a protein called osteoprotegerin in CPDD. Genetic abnormalities in this protein were identified as one cause of this disease. In this proposal will explore the mechanisms through which genetic abnormalities in osteoprotegerin cause CPDD, with the ultimate goal of developing new therapies for all patients with CPDD.

PI_NAMEs: ROSENTHAL, ANN K (contact)

PROJECT_TERMS: Affect;Affinity;American;Amino Acids;Arthritis;articular cartilage;Behavior;Binding;Biological Markers;Bone Density;Calcium Pyrophosphate;Calcium pyrophosphate deposition disease;Cell membrane;Cell surface;Characteristics;Chondrocytes;Chromatography;Clinical;Code;Crystal Formation;Data;dimer;Dimerization;Disease;Disease Clusterings;disease phenotype;early onset;effective therapy;Elderly;gain of function;gain of function mutation;Goals;Heparin Binding;Heparitin Sulfate;ICD-9;IGF1 gene;In Vitro;in vivo Model;innovation;joint destruction;joint injury;kindred;Ligands;loss of function;Measures;Membrane;military veteran;Molecular Abnormality;Molecular Sieve Chromatography;Mutation;new therapeutic target;NF-kappa B;novel therapeutics;older patient;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteopenia;Pain;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;premature;prevent;Proteins;Publishing;receptor;receptor binding;Recombinants;Reporting;Risk Factors;Roentgen Rays;Role;stem;Structure;subchondral bone;Surface Plasmon Resonance;Terminator Codon;Tissues;TNF-related apoptosis-inducing ligand;TNFRSF11B gene;TRANCE protein;Transforming Growth Factor beta;Tumor necrosis factor receptor 11b;Veterans;Work

PROJECT_TITLE: Mutations in Osteoprotegerin Cause Calcium Pyrophosphate Deposition Disease


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE  The proposed research will use a national medical record system of over 10 million patients to evaluate the impact of U.S. eviction moratoria policies on use and costs of homeless and acute healthcare services in communities across the country. The project will deploy an innovative method to identify evictions in medical records that can be used for future evaluations and utilize qualitative interviews with dyads of tenants and landlords in urban and rural regions to understand their experiences during eviction moratoria. Together, this work will inform future policies and practices related to evictions, homelessness, and acute care use with the goal of addressing social and health inequities in vulnerable populations.

PI_NAMEs: TSAI, JACK  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acute;acute care;Address;Affect;Area;care costs;care systems;Centers for Disease Control and Prevention (U.S.);Characteristics;Cities;Clinical;Communities;cost;Country;COVID-19 pandemic;Data;Data Analyses;Data Science;design;development policy;Disparity;electronic medical record system;Emergency Situation;Ethnic Origin;Evaluation;Event;experience;Failure;Future;Goals;Health;Health Care Costs;Health Care Sector;health care service;health data;health disparity;health inequalities;Healthcare;Healthcare Systems;Homelessness;Housing;housing instability;improved;Incentives;innovation;Integrated Health Care Systems;Interview;Investments;Knowledge;Link;Medical Records;Methods;Natural experiment;Natural Language Processing;New York;Outcome;Patients;payment;Personal Satisfaction;Persons;Policies;Policy Developments;Population Heterogeneity;Poverty;prevent;Prevention;Process;programs;Property;psychosocial;Public Health;Race;Records;recruit;Research;Risk;Role;rural area;Sampling;Services;sex;social;social health determinants;sociodemographics;System;Systems Integration;Testing;Texas;therapy development;Time;United States Department of Veterans Affairs;urban area;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Evaluating the impact of U.S. eviction moratoria on acute care use and costs


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of this CBI Training Program is to provide students with the intellectual and technical skills to solve important and complex biological problems with implications for impacting human health and treatment of disease that can be most effectively addressed by studies at the chemistry-biology interface. This University of Pennsylvania-based program involves 34 faculty, students from complementary graduate groups and a program that combines chemistry-biology-interface research, didactic course-work, symposia, luncheons, retreats, and career development plans to create future leaders working at the Chemistry-Biology Interface.

PI_NAMEs: MARMORSTEIN, RONEN  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemistry;pre-doctoral;Training

PROJECT_TITLE: Predoctoral Training at the Chemistry-Biology Interface

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Systematic screening for tuberculosis (TB) in high-risk populations, including people living with HIV and all persons living in high TB prevalence settings is recommended by the World Health Organization as an important strategy to improve TB control. While community-wide TB screening in high burden settings is unlikely to be sustainable, community-based systematic TB screening among non-household contacts of newly diagnosed TB patients (contact tracing) using trained peers (recent TB patients) may represent an efficient and effective implementation strategy that compliments existing strategies and is sustainable. The proposed research will develop and pilot a theory-informed, peer-led, multicomponent implementation strategy to improve TB contact tracing among non-household contacts of HIV-positive and HIV-negative adults in Lusaka, Zambia.

PI_NAMEs: KERKHOFF, ANDREW  (contact)

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: acceptability and feasibility;Adult;Africa South of the Sahara;behavior change;career;Caring;case finding;Cause of Death;Clinic;clinical epidemiology;Clinical Research;Cluster randomized trial;Collaborations;Communicable Diseases;Communities;Consolidated Framework for Implementation Research;Contact Tracing;design;Detection;Diagnosis;diagnostic tool;Education;Educational workshop;Effectiveness;Enrollment;experience;experimental study;Face;Fellowship;Foundations;Gender Role;Goals;Health;Health care facility;high risk population;HIV;HIV Seronegativity;HIV Seropositivity;HIV/TB;Household;implementation intervention;implementation research;implementation science;implementation strategy;improved;improved outcome;indexing;Individual;Infectious Diseases Research;Infrastructure;International;Intervention;Interview;Knowledge;Location;Maps;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Newly Diagnosed;novel diagnostics;Outcome;outreach;Patients;peer;Persons;Physicians;Pilot Projects;preference;Prevalence;Provider;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Design;Research Methodology;Research Personnel;Resource-limited setting;Resources;Risk;Scientist;screening;social stigma;Social support;South Africa;Surveys;theories;Theory of Change;Time;Tracer;Training;transmission process;Travel;Tuberculosis;Tuberculosis diagnosis;Work;World Health Organization;Zambia

PROJECT_TITLE: Feasibility and acceptability of a peer-led strategy to improve community tuberculosis case finding among non-household contacts in Zambia

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE  Managing the impact of thrombosis is central to influenza-induced acute myocardial infarction. This research proposal will investigate the thrombotic and antiviral role of a previously undescribed mechanism in platelets that involves the retinoic acid-inducible gene-I (RIG-I) receptor signaling. Defining the signaling mechanisms that lead to influenza mediated activation of platelets and to their reprograming toward more robust antiviral and thrombotic responses, will enable us to design therapies managing thrombosis without negatively affecting antiviral response during infection.

PI_NAMEs: KOUPENOVA, MILKA  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adhesions;Affect;antagonist;Anti-viral Response;Biology;Blood;Blood Platelets;Bone Marrow;burden of illness;Cardiovascular Diseases;Cells;Cessation of life;Collaborations;Communicable Diseases;Consultations;Coronary;Cytoplasmic Receptors;Detection;Diagnostic;Disease;Event;experience;flu;Functional disorder;Generations;Genes;Goals;Human;Immune;Immune response;Immunity;in vivo;Incidence;Incubated;Individual;Infection;Influenza;influenza infection;Knock-out;Lung;Mediating;Megakaryocytes;Messenger RNA;Mitochondria;Modeling;Molecular;mouse model;mRNA Expression;Mus;Nature;novel;Outcome;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern recognition receptor;pharmacologic;Phenotype;Platelet Activation;Principal Investigator;programs;Protein Analysis;Proteins;receptor;Receptor Signaling;Regulation;Research;Research Proposals;response;RNA;RNA Viruses;Role;Secondary Prevention;Signal Pathway;Signal Transduction;Signaling Protein;Syndrome;Therapeutic;therapeutic target;therapy design;Thrombosis;thrombotic;Time;TLR7 gene;Tretinoin;Up-Regulation;Vaccination;vaccine efficacy;vascular injury;Viral;viral RNA;Viremia;Virion;Virus Diseases

PROJECT_TITLE: Mechanisms of platelet reprogramming during influenza infection

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Our understanding of how the retina neurons works fails to account for responses to natural images—the stimuli for which the system evolved to work. The proposed work will improve our understanding of this issue. This is a requisite step in identifying the role of key circuit mechanisms in normal and aberrant natural vision and in the design of devices such as retinal prostheses to replicate or replace the retina.

PI_NAMEs: RIEKE, FREDERICK M (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Amacrine Cells;artificial neural network;Behavioral;Biological;cell type;Cells;Code;Cone;contrast enhanced;Dependence;Device Designs;Engineering;experimental study;Feedback;ganglion cell;high dimensionality;horizontal cell;Image;imaging properties;improved;insight;Kinetics;Light;light intensity;Mediating;Modeling;neglect;neural model;neurotransmission;novel;Photic Stimulation;Photoreceptors;Phototransduction;predicting response;predictive modeling;Primates;Process;Property;receptive field;recruit;response;Retina;Retinal Cone;Retinal Ganglion Cells;retinal neuron;retinal prosthesis;Rod;Role;Shapes;sight restoration;Signal Transduction;Stimulus;Structure;System;Testing;Time;tool;Vertebrate Photoreceptors;Vision;Work

PROJECT_TITLE: Mechanisms controlling retinal responses to natural stimuli

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative When we learn to sing or speak or play a musical instrument, our motor system has to produce the right sounds under auditory and visual guidance. To understand the neural mechanisms of this sensorimotor integration process, we will train rhesus monkeys in a novel behavioral task that allows them to produce sound sequences, and we will measure the monkey’s brain activity with functional MRI and MRI-guided electrode recordings. Our studies will elucidate the evolution of speech and music and will help to develop a better understanding of higher-level disorders of speech and language, including apraxia of speech and non-fluent aphasia.

PI_NAMEs: RAUSCHECKER, JOSEF P (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Afferent Neurons;Agreement;anatomical tracer;Anatomy;Animals;Anterolateral;Apraxia;Area;Ataxia;Auditory;Auditory area;auditory processing;awake;Behavioral;Brain;Brain region;Broca Aphasia;Cells;Clip;Cognition;Communication;Consensus;Data;density;Disease;Dissociation;Distant;Dorsal;dorsal visual stream;Electrodes;Electrophysiology (science);Evolution;Exposure to;Functional Magnetic Resonance Imaging;Funding;Hearing;Human;Image;improved;instrument;Laboratories;Language;Language Disorders;Learning;Link;Location;Macaca mulatta;Magnetic Resonance Imaging;Measures;Microelectrodes;Modeling;Monkeys;Motion;Motor;Motor Cortex;motor learning;multi-electrode arrays;multisensory;Music;Nature;neural;Neurodegenerative Disorders;neuromechanism;Neurons;nonhuman primate;novel;Parietal;Parietal Lobe;Pathway interactions;Perception;Play;Prefrontal Cortex;Primates;Process;Production;Property;putamen;rehabilitation strategy;response;Role;Sensory;sensory integration;sensory system;Signal Transduction;sound;Speech;Speech Disorders;Stimulus;Stream;Stroke;success;System;Techniques;Testing;Training;ventral visual stream;Visual;visual motor;Visual System;vocalization;Work

PROJECT_TITLE: Sensorimotor integration in the auditory dorsal stream

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: NARRATIVE Patients with intraductal papillary mucinous neoplasms (IPMNs), due to elevated risk of developing pancreatic cancer (PC), are subjected to active surveillance, and represent an ideally suited cohort for evaluating agents that can prevent progression to PC. Building on our recently completed Phase I studies, the project proposes to undertake a Phase II Clinical trial to determine the effectiveness of δ-tocotrienol (DT3) in preventing IPMN- to-PC progression, and employ cutting edge approaches (radiomics, animal models, organoids, multi-omics) to discern the underlying mechanism(s) of DT3 action. This information will lay the groundwork for a confirmatory study, which will bring a new non-operative option for patients with IPMN to reduce their risk of developing cancer.

PI_NAMEs: BATRA, SURINDER K.;MALAFA, MOKENGE P. (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Abdomen;Address;Animal Model;Apoptosis;Apoptotic;Area;arm;Biochemical;Biological Availability;Biological Markers;biomarker discovery;biomarker identification;cancer cell;Cancer Center;Cell Line;Cell Proliferation;Cells;Cessation of life;Chemopreventive Agent;Clinic;Clinical;Clinical Trials;cohort;Complex;Consensus;Correlative Study;Data;delta tocotrienol;Development;Diagnosis;driver mutation;drug development;druggable target;early phase trial;effectiveness evaluation;efficacy evaluation;Endoscopic Ultrasonography;FDA approved;Genetic Engineering;Genetically Engineered Mouse;glycosylation;Goals;Guidelines;high risk;high risk population;Human;imaging study;immune cell infiltrate;Individual;Induction of Apoptosis;insight;Institution;International;KRAS oncogenesis;KRAS2 gene;Lesion;Magnetic Resonance Imaging;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;Medical center;men;Micronutrients;Modeling;Molecular;Molecular Target;Monitor;mortality;mouse model;Mucinous Neoplasm;Mucins;multidisciplinary;multiple omics;Mus;Mutation;Nebraska;neoplasm therapy;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Oral;Organoids;Outcome;overexpression;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Papillary;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;phase 1 study;phase I trial;Phase II Clinical Trials;Physiological;potential biomarker;predicting response;predictive marker;prevent;Prevention;Prevention trial;primary endpoint;Progression-Free Survivals;Proliferating;radiomics;randomized placebo controlled trial;Recommendation;Regulation;Resistance;response;response biomarker;Risk;Risk Reduction;risk stratification;Safety;Sampling;Serum;Signal Transduction;standard of care;Testing;Therapeutic;therapy development;Tissues;treatment duration;treatment response;trial design;tumor;tumor growth;tumor progression;United States;Universities;Woman;Work

PROJECT_TITLE: Novel Therapy to Inhibit IPMN Progression

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The field of alcohol studies lacks racial and ethnic diversity, and few systematic efforts exist to engage undergraduate students in alcohol-related research or coursework. This project will engage undergraduates from underrepresented minority groups in a coordinated program including didactic coursework, intensively mentored research experiences, and professional development activities related to alcohol studies and careers in alcohol-related fields. The goal is to broaden the diversity of the next generation of researchers in the field of alcohol studies.

PI_NAMEs: GRILLO, WENDY HECK (contact);MARSHALL, SIMON ALEXANDER

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: African American population;alcohol effect;alcohol research;alcohol use disorder;Alcohols;Biological;Biomedical Research;Brain;career;career development;career networking;Clinical;Collaborations;Communities;curriculum development;demographics;Development;Disparity;Education;Educational process of instructing;ethnic diversity;Evaluation;experience;Goals;Graduate Education;graduate school;Home;improved;Individual;innovation;Institution;interest;Job Application;Laboratories;Laboratory Procedures;Laboratory Research;meetings;member;Mentors;Minority Groups;multidisciplinary;Neurologist;Neurosciences;next generation;North Carolina;operation;Participant;Population;posters;Privatization;Professional Education;programs;Psychiatrist;Public Health;racial diversity;Research;Research Ethics;Research Personnel;research study;Research Training;Resources;Science;skills;social;Social Impacts;Societies;STEM career;STEM research;Students;summer research;Supervision;symposium;Training;undergraduate research;undergraduate student;Underrepresented Minority;Universities

PROJECT_TITLE: Duke-N.C. Central Alcohol Research & Education (D-CARE)

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE This study will identify important environmental exposures and epigenetic mechanisms that preceded miscarriage in two large US studies of pregnant women. It will focus especially on miscarriages not caused by chromosomal problems and study chemical toxicants and sociodemographic and health-related stresses in pregnant women to discover risk factors for miscarriage that can be prevented and to guide clinical practice and public health.

PI_NAMEs: FICHOROVA, RAINA N. (contact);PANETH, NIGEL SEFTON

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Adverse effects;adverse pregnancy outcome;Affect;Anatomy;Biological;Biological Factors;biological specimen archives;biomarker driven;Blood;Blood Coagulation Disorders;Case/Control Studies;Chemical Exposure;Chemicals;Chromosomal Loss;Chromosome abnormality;circulating microRNA;Circulation;Clinical;clinical practice;cohort;Communities;comparison control;Conceptions;Conceptus;Data;Data Set;Databases;diagnostic biomarker;differential expression;Distal;early pregnancy;early pregnancy loss;Elements;Endometrial;environmental chemical;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Event;Functional disorder;Gene Expression;Gestational Age;Glues;Health;health data;Hemostatic Agents;Hormone imbalance;Inflammation;Injury;innovation;insight;Laboratories;Lead;Live Birth;Massachusetts;Maternal Health;Measures;Mediating;Michigan;MicroRNAs;modifiable risk;Molecular;Molecular Profiling;mRNA Transcript Degradation;multidimensional data;National Institute of Child Health and Human Development;North America;novel;Oxidative Stress;Participant;participant enrollment;Pathway interactions;Pattern;Phenotype;Physiological;Placenta;predictive modeling;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnant Women;Prenatal Diagnosis;prenatal testing;prevent;Process Measure;prospective;Public Health;Public Health Practice;public health priorities;Reporting;Research;Resources;Risk Factors;Risk Marker;RNA;Sampling;Single Nucleotide Polymorphism;social;social factors;sociodemographics;socioeconomics;Spontaneous abortion;Strategic Planning;Stress;stressor;Symptoms;Technology;Testing;Time;Tissues;Toxic Environmental Substances;toxicant;transcriptomics;Translational Repression;trophoblast;Untranslated RNA;Urine;Villous;Woman

PROJECT_TITLE: Molecular Antecedents of Miscarriage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

ORG_NAME: AIMMAX THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE The emergence of multidrug resistant Neisseria gonorrhoeae, including strains resistant to the injectable antibiotic ceftriaxone, the only remaining treatment recommended by the CDC, represents a serious and urgent threat to US public health. With more than 600,000 new cases of gonorrhea in the US each year, the spread of an untreatable strain would have devastating consequences, highlighting the need for prompt action to identify and develop new classes of antibiotics to treat this disease. We aim to develop a novel oral antibiotic for the treatment of drug-resistant N. gonorrhoeae to address the urgent threat of untreatable gonorrhea.

PI_NAMEs: WANG, LAURENE  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: absorption;Address;Adherence;Advanced Development;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Azithromycin;bactericide;Biological;Biological Assay;Biological Availability;Canis familiaris;Cardiovascular system;Ceftriaxone;Cell Line;Cells;Cephalosporins;Chlamydia;Chlamydia trachomatis;Classification;Clinic;Clinical;clinical development;Clinical Research;Clinical Trials;cytotoxicity;Development;Disease;Dose;Doxycycline;Drug Interactions;Drug Kinetics;drug metabolism;drug-resistant gonorrhea;Drug-resistant Neisseria Gonorrhoeae;effective therapy;Evaluation;Excipients;Exclusion;Exposure to;Fertility;Fiber;first-in-human;Formulation;Frequencies;Goals;Gonorrhea;Guidelines;Hepatocyte;Human;improved;In Vitro;Individual;Infection;Inferior;inhibitor;Injectable;Instruction;Intestines;Intramuscular Injections;Isoenzymes;Kinetics;Laboratory Diagnosis;Life;Liver Microsomes;Long-Term Effects;Macrolide-resistance;manufacture;manufacturing process;manufacturing scale-up;Marketing;Measures;Modernization;Multi-Drug Resistance;Mutation;Neisseria gonorrhoeae;No-Observed-Adverse-Effect Level;novel;novel antibiotic class;Oral;Organism;outbreak concern;pathogen;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacology Study;Phase;Physicians;Plasma;Plasma Enhancement;pre-Investigational New Drug meeting;Program Development;programs;Public Health;Rattus;Recommendation;Reporting;Reproductive Health;Resistance;resistant strain;Risk;Safety;Series;Sexually Transmitted Diseases;Signs and Symptoms;Site;Small Business Innovation Research Grant;Streptogramins;success;Technology;Therapeutic;therapy development;Time;Toxic effect;Toxicology;Transfection;transmission process;treatment guidelines;urgent and serious threat

PROJECT_TITLE: Development of a Novel Oral Antibiotic for the Treatment of Drug Resistant Gonorrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Infectious Diseases;Neurosciences;Pain Research;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder (“enteric shingles”). We recently found that a persistent active VZV infection, a form of enteric shingles, is associated with achalasia, a severe disease in which the passage of food from esophagus to stomach is impaired. We now propose to eradicate VZV to determine whether its association with achalasia is causal, to identify the genetic basis behind VZV reactivation in the esophagus, and the relationship of mast cells to VZV reactivation in achalasia and its associated pain.

PI_NAMEs: GERSHON, ANNE A. (contact);GERSHON, MICHAEL D

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Achalasia;activity marker;Affect;Aftercare;Barium;Cancer Patient;Cell Count;Cell Degranulation;Chickenpox;Choline O-Acetyltransferase;Clinical;Clinical Trials;co-infection;Cutaneous;Data;Detection;Development;Diagnostic tests;diagnostic tool;Disease;Endoscopic Biopsy;Enteral;Enteric Nervous System;enteric pathogen;Esophageal achalasia;esophageal cancer patient;Esophageal Tissue;Esophagectomy;Esophagus;Exanthema;Failure;Food;Functional disorder;Ganglia;Gastrointestinal Diseases;Genes;Genetic;Giant Cells;Herpes zoster disease;Herpesviridae;Herpesvirus Type 3;immunoreactivity;Impairment;improved;Individual;Infection;Inferior esophageal sphincter structure;inhibitory neuron;insight;instrument;Intestines;Investigation;Legal patent;Lytic;Malignant Neoplasms;Manometry;mast cell;Nerve;Nerve Fibers;Neurites;Neurons;next generation sequencing;Nitric Oxide Synthase;noninvasive diagnosis;Organ Donor;Pain;pain symptom;Pathogenesis;Patient Outcomes Assessments;patient subsets;Patients;Peripheral;Peristalsis;Phase;Phenotype;Physiology;Proteins;Publishing;Relaxation;Reporting;Resected;Resolution;Role;Saliva;Salivary;Sampling;Selection for Treatments;Severities;Signs and Symptoms;Simplexvirus;Skin;Smooth Muscle;Source;Specificity;Specimen;Stomach;Symptoms;Tail;Testing;Time;Tissues;Transcript;valacyclovir;Viral;viral DNA;Viral Load result;Viremia;Virus Diseases

PROJECT_TITLE: VZV in the enteric nervous system: pathogenesis and consequences

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: OVERALL: NARRATIVE The Population Studies Center (PSC) at the University of Michigan provides critical research infrastructure to promote the interdisciplinary study of human population dynamics, with a focus on the areas of demography, population health and reproductive health. PSC supports the design, creation, and use of new data that can be used to inform interventions and policies to improve health and reduce health disparities.

PI_NAMEs: BURGARD, SARAH A. (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: American;analytical method;Area;Award;Biosocial;career development;cohesion;Collaborations;college;Communities;computing resources;cost;cost effective;Country;Data;data access;Data Analyses;Data Collection;Data Storage and Retrieval;Demography;design;Development;Discipline;Educational workshop;Environment;Event;experience;Faculty;Family;Family health status;Family Study;Feedback;Fertility;flexibility;Fostering;Funding;Future;Generations;Goals;Grant;Growth;Health;High Performance Computing;human population study;improved;Incubators;Infrastructure;innovation;Institution;Interdisciplinary Study;intergenerational;Internet;Intervention;Investments;Life Cycle Stages;Mentors;method development;Methods;Michigan;Monitor;multimodality;National Institute of Child Health and Human Development;Nepal;novel strategies;outreach services;Ozone;panel study of income dynamics;Peer Review;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;Population Dynamics;Population Group;population health;Population Sciences;Population Study;Process;Productivity;programs;Publications;Reduce health disparities;Reproductive Health;Request for Applications;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;Running;Schools;Science;Scientist;Services;Study Section;success;Surveys;synergism;Technology;Testing;tool;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Michigan Research Infrastructure for Population Sciences


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE This project is relevant to public health through its generation of novel population- and individual-level knowledge on the prevalence and health consequences of loneliness and social isolation in the last years of life among older adults with Alzheimer’s Disease and Related Dementia. The proposal is consistent with the National Institute on Aging’s mission and core research agenda to understand the impact of social interaction on healthy aging (NIA Goal A), develop effective interventions to maintain health and well-being among older adults (NIA Goal B), and to improve our understanding of Alzheimer’s disease and the aging brain (NIA Goal C). The results from this work have the potential to impact the health and well-being of millions of aging adults on an individual and population level.

PI_NAMEs: KOTWAL, ASHWIN AJIT (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: active lifestyle;Address;Adult;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Award;career;Caregivers;Caring;Cessation of life;Clinical;Cognition;cohort;Communities;Data;Decision Making;Dementia;Distress;effective intervention;Emergency department visit;Emotional;end of life;Epidemiology;experience;Family;Feeling;Foundations;Friends;Functional impairment;Future;General Population;Generations;Geriatrics;Goals;Health;Health and Retirement Study;health care quality;Health Services Research;Healthcare;healthy aging;High Prevalence;high risk population;hospice environment;hospice utilization;Impaired cognition;implementation science;improved;Individual;Intervention;Interview;Knowledge;late life;Life;Link;Literature;Loneliness;Medical;Medicare claim;Mental Depression;Mentorship;mild cognitive impairment;Mission;mortality;National Institute on Aging;novel;older adult;Outcome;Palliative Care;Patients;Personal Satisfaction;Persons;Physicians;poor health outcome;Population;Prevalence;Public Health;Quality of Care;Quality of life;Research;Risk Factors;Sampling;social;Social Environment;social factors;Social Interaction;Social isolation;Social Work;Source;Structure;Surveys;Testing;Time;Training;Visit;Work;Writing

PROJECT_TITLE: Loneliness and Social Isolation Among Older Adults with and without Alzheimer's Disease and Related Dementia in the Last Years of Life

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

PROJECT_TERMS: Applications Grants;Area;Award;career;Charge;Clinic;Coffee;cohesion;Collaborations;Communities;community building;cost effectiveness;Data;design;Development;Discipline;Effectiveness;Ensure;Faculty;Feedback;Fostering;Funding;Goals;Growth;Health Services Accessibility;Hour;Incubators;innovation;Institution;Lead;Leadership;Life Cycle Stages;meetings;member;Michigan;Mission;National Institute of Child Health and Human Development;outreach services;Population;Population Dynamics;Population Sciences;Population Study;Preparation;Productivity;professional atmosphere;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Self-Examination;Series;Service provision;Services;social;social space;synergism;Time;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE: Although outdoor air pollution causes asthma attacks in children, healthcare providers caring for children with asthma lack proper tools to help prevent asthma attacks caused by air pollution. Identifying biomarkers that predict pollution-triggered asthma attacks will allow development of new therapies, thus providing healthcare providers with evidence-based interventions to help children with asthma better control their disease.

PI_NAMEs: ROSSER, FRANZISKA  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Air;Air Pollution;airway epithelium;ambient air pollution;Ancillary Study;Asthma;asthma exacerbation;Behavior Therapy;Behavioral;Biological Markers;Biological Specimen Banks;biomarker identification;career development;Caring;Cause of Death;Child;Child Care;Child health care;Childhood Asthma;Chronic;Clinical;clinical care;Clinical Management;clinical practice;Clinical Trials;cohort;cost;Cross-Sectional Studies;Data;design;Development;Development Plans;differential expression;Disease;DNA Methylation;Emergency Situation;Environment;Epidemiology;Epigenetic Process;epigenetic variation;Epithelium;ethnic diversity;Evidence based intervention;Exposure to;fine particles;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic Markers;genome-wide;Genomics;Goals;Government;health care service utilization;Health Personnel;Hospitalization;improved;indexing;Individual;insight;Institution;Intervention;K-Series Research Career Programs;Knowledge;Lead;Lung Diseases;Mentors;Methods;Methylation;methylation biomarker;Modeling;Nasal Epithelium;Nose;novel;novel therapeutics;Nutritional;Outcome;Particulate Matter;Pathogenesis;pediatrician;Pilot Projects;Play;Policies;pollutant;Pollution;Positioning Attribute;predictive marker;predictive tools;Predisposition;Preparation;prevent;Proxy;Puerto Rican;randomized, clinical trials;Recommendation;Research;response;Risk;risk prediction;Sampling;Schools;skill acquisition;skills;Statistical Data Interpretation;Statistical Methods;Susceptibility Gene;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Tissues;tool;traffic-related air pollution;Training;transcriptomics;United States Environmental Protection Agency;United States National Institutes of Health;Visit;Vitamin D;Work

PROJECT_TITLE: Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in children

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WARE, ERIN BAKSHIS (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Applications Grants;Area;Award;Biosocial;career;Collaborations;Consultations;Data;Data Collection;Data Science;design;Development;Discipline of Nursing;Economics;Education;Educational workshop;Epidemiology;experience;Experimental Designs;Faculty;Family;Feedback;Fertility;Funding;Grant;Health;health disparity populations;Health Sciences;improved;Infrastructure;innovation;Institution;Instruction;interest;intergenerational;Intervention;Lead;Leadership;Learning;Left;Life Cycle Stages;member;Mentors;Michigan;Modeling;National Institute of Child Health and Human Development;outreach;outreach services;Peer Review;Personal Satisfaction;Pilot Projects;Population;Population Dynamics;Population Genetics;population health;Population Research;Population Sciences;Population Study;Preparation;Process;Productivity;Program Development;programs;Public Health;Records;recruit;Reproductive Health;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Research Support;Resources;Science;Scientist;Senior Scientist;Series;Services;Site;skills;social;Social Sciences;Social Work;Sociology;Source;statistics;Structure;Study Section;success;summer institute;summer research;Survey Methodology;Surveys;Talents;Testing;Triage;United States National Academy of Sciences;United States National Institutes of Health;Universities;University resources;Work;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Substance Misuse

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE At least 15.4 million opioid prescriptions in the United States are provided each year during surgical care, and many of these prescriptions are excessive or are written in a manner that increases the risk of opioid-related adverse events, such as overdose. To reduce these harms, policymakers and payers in most states have enacted policies that limit opioid prescribing for acute pain or mandate clinicians to review prescription drug monitoring program databases before prescribing opioids, but the effects of these policies on opioid prescribing, high-risk prescribing, opioid-related adverse events, and patient-reported outcomes among surgical patients are unknown. We will close these knowledge gaps using rigorous quasi-experimental methods, comprehensive medical claims from both privately and publicly insured adults, and data from a statewide Michigan surgical registry, thus revealing whether the policies should be expanded more broadly or whether other approaches are needed to mitigate the harms of perioperative opioid prescribing.

PI_NAMEs: CHUA, KAO-PING ;WALJEE, JENNIFER FILIP (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Accounting;Acute Pain;addiction;Adult;Adverse event;Affect;Automobile Driving;Benzodiazepines;Caring;Characteristics;comorbidity;Coupled;Data;Databases;Day Surgery;design;Development;dosage;Equilibrium;Exclusion;Frequencies;Future;Harm Reduction;Heterogeneity;high risk;Hospitals;innovation;Institution;Insurance Carriers;Interruption;Intervention;Knowledge;Link;Medicaid;Medical;Medicare;Methods;Michigan;Morbidity - disease rate;mortality;novel;Operative Surgical Procedures;Opioid;opioid epidemic;opioid overdose;opioid policy;opioid use;opioid use disorder;Outcome;Overdose;Pain;Pain management;Patient Outcomes Assessments;patient population;Patients;Pattern;Perioperative;perioperative morbidity;Pharmacy facility;Play;Policies;Policy Maker;Population;Postoperative Pain;prescription drug abuse;prescription monitoring program;prescription opioid;Privatization;Procedures;Quasi-experiment;Registries;Risk;Role;Sample Size;satisfaction;Surgeon;surgical pain;System;Time Series Analysis;United States;Variant;Writing

PROJECT_TITLE: Evaluating Policy Interventions to Decrease Excessive and Risky Perioperative Opioid Prescribing


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: WEST, BRADY T (contact)

PROJECT_TERMS: adaptive intervention;Advisory Committees;Applications Grants;Archives;Area;Big Data;Biosocial;cloud storage;Collaborations;Communities;Complex;Computer software;computing resources;Consult;Consultations;cost effectiveness;Data;data access;Data Analyses;Data Collection;data enclave;data management;Data Protection;Data Science;Data Scientist;Data Security;Data Storage and Retrieval;data visualization;design;Development;Discipline;Educational workshop;Ensure;Environment;Ethnography;flexibility;Funding;Future;Genetic;Grant;High Performance Computing;improved;Infrastructure;innovation;Institution;Knowledge;Link;Location;member;Mentors;Methodology;Methods;Michigan;National Institute of Child Health and Human Development;Politics;Population;Population Dynamics;population health;Population Sciences;Population Study;Productivity;programs;Provider;Quasi-experiment;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resource Sharing;Resources;Role;Sampling;Scientist;Services;skills;social;Source;statistics;STC1 gene;STC2 gene;success;summer institute;summer program;summer research;Surveys;Techniques;Technology;Time;tool;Training;training opportunity;United States National Institutes of Health;Universities;Vertebral column;virtual;Wages;Work

PROJECT_TITLE: Scientific/Technical Core


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

PHR: CALHM1 and CALHM3 form a heteromeric voltage-gated CALHM1/3 ion channel that releases neurotransmitter in response to action potentials in taste bud cells that respond to sweet, bitter and umami tastes, relaying taste information to nerve cells to mediate taste perception. Temperature strongly regulates the perception of these tastes, but the effects of temperature on taste bud cell electrical excitability and CALHM1/3 channel gating mechanisms are largely unknown. Because the sense of taste plays an important role in the quality of human life, identification of mechanisms that regulate neurotransmitter release by taste bud cells to modulate perception of taste intensity may provide new targets for pharmacological and nutritional manipulation of taste sensations, which may be important in obesity, diabetes and formulations of food and medicines.

PI_NAMEs: FOSKETT, JAMES KEVIN (contact);MA, ZHONGMING

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Action Potentials;Address;Affect;base;Brain;Central Nervous System;Charge;Cryoelectron Microscopy;Dependence;Diabetes Mellitus;Diameter;Electrophysiology (science);Elements;Engineering;Esthesia;Evoked Potentials;extracellular;Family;Food;Formulation;G-Protein-Coupled Receptors;Genetic;Goals;Homologous Gene;Human;insight;Ion Channel;Ions;Kinetics;Knockout Mice;Life;Mediating;Medicine;Membrane Proteins;Methods;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;Nerve;Neurons;neurotransmitter release;Neurotransmitters;novel;Nutritional;Obesity;Pathway interactions;Perception;Peripheral;Permeability;pharmacologic;Physiological;Physiology;Play;Proteins;Regulation;response;Role;Scheme;Signal Transduction;Structure;System;Taste Bud Cell;Taste Buds;Taste Perception;taste system;taste transduction;Temperature;TRPM5 gene;Type II Epithelial Receptor Cell;voltage

PROJECT_TITLE: Molecular physiology of CALHM ion channels

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]