NIH_SPENDING_CATS: Neurosciences

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide important insights into the regulation of the human stress (“fight-or-flight”) response, which impacts cardiovascular, respiratory, metabolic, and mental health. Understanding how hormones are secreted into the bloodstream to trigger fight-or-flight, may lead to new therapies to manage the physiological manifestations of stress effectively.

PI_NAMEs: ANANTHARAM, ARUN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acetylcholine;Adrenal Medulla;Affinity;Arousal;Biogenic Amines;biological adaptation to stress;Blood Circulation;Cardiac;Cardiovascular system;Catecholamines;Cell secretion;Cells;Characteristics;Charge;cholinergic;Chromaffin Cells;Chromaffin granule;Circulation;Coupled;Cyclic AMP;Cytoplasmic Granules;Data;desensitization;Dynamin;Electrophysiology (science);Emotional;Event;Exocytosis;Fiber;fighting;Frequencies;G-Protein-Coupled Receptors;Guanosine Triphosphate Phosphohydrolases;Hormone secretion;Hormones;Human;Hypoglycemia;Image;In Situ;In Vitro;Injury;insight;Laboratories;Link;Lung;Measures;Mental Health;Metabolic;Modality;Molecular;natural hypothermia;Neurons;Neurotransmitters;novel therapeutics;Output;Pathway interactions;peptide hormone;Peptides;Perfusion;pharmacologic;phospholipase C epsilon;Physiological;pituitary adenylate cyclase activating polypeptide;postsynaptic;presynaptic;Property;Proteins;Psyche structure;Public Health;Reaction;receptor;Receptor Activation;Regulation;Research;respiratory;response;Role;seal;sensor;Signal Pathway;Signal Transduction;Slice;Splanchnic Nerves;Stimulus;Stress;stressor;Sympathetic Nervous System;Synapses;Synaptic plasticity;Synaptic Receptors;synaptotagmin;synaptotagmin VII;Testing;Time;tool;Total Internal Reflection Fluorescent;Training;Translating;Variant;Veins

PROJECT_TITLE: Pre and post-synaptic pathways underlying the stress response in the adrenal medulla


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Emergency Care;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Patient Safety;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The National Drug Abuse Treatment Clinical Trials Network (CTN) conducts clinically relevant research on the treatment of substance use disorders in real-world settings, with an increasing emphasis on conducting studies in general medical settings. The New England Consortium Node of the CTN is poised to foster the development of effective, scalable, and sustainable interventions for individuals with a variety of substance use problems, so that they can be offered effective treatment in whatever healthcare setting they enter, thus improving overall public health.

PI_NAMEs: D'ONOFRIO, GAIL  (contact);WEISS, ROGER D.

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Accident and Emergency department;acute care;addiction;Address;Adolescent;adolescent substance use;Adult;Alcohols;Boston;care seeking;Caring;Characteristics;Child Care;Chronic Disease;Clinic;Clinical;clinical infrastructure;clinical practice;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials Network;clinically relevant;Collaborations;Communities;Computers;Connecticut;cost efficient;Development;Discipline of obstetrics;Doctor of Philosophy;Drug abuse;Drug usage;effective therapy;Emergency Care;evidence base;Face;Fostering;Friends;Funding;Gynecologic;Health;Health care facility;health care settings;health information technology;Health Personnel;Health system;Healthcare;Healthcare Systems;Helping to End Addiction Long-term;Heterogeneity;high risk men;HIV;HIV Infections;Hospitalization;Hospitals;improved;Individual;innovation;inpatient service;Intervention;Leadership;Link;Medical;Medical center;medical specialties;Medicine;men who have sex with men;Mental Health Services;methamphetamine use;Modeling;New England;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Paper;Patients;Pediatric Research;Peer Review;Persons;Pharmaceutical Preparations;Play;Population;pragmatic trial;prevent;Primary Care;primary care patient;Productivity;psychiatric comorbidity;Psychiatric therapeutic procedure;psychosocial;Public Health;Publications;Publishing;Randomized, Controlled Trials;Recording of previous events;recruit;reduced substance use;Research;Research Infrastructure;Research Personnel;Risk;Science;screening, brief intervention, referral, and treatment;Seminal;Series;Severities;Site;sociodemographics;Speed;stimulant use disorder;substance use;Substance Use Disorder;substance use treatment;Testing;Tobacco;treatment program;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: The National Drug Abuse Clinical Trials Network: New England Consortium Node


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Rural Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Huntsman Cancer Institute (HCI) will provide leadership in the development and conduct of NCTN cooperative clinical trials; robust accrual of patients from the Mountain West to a broad array of NCTN trials, including trials in rare cancers; and unique assets that can contribute value to the NCTN Program. HCI will work vigorously to ensure the success of the NCTN's cooperative endeavors to eradicate cancer.

PI_NAMEs: SOARES, HELOISA PRADO (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Academic Medical Centers;Address;Advisory Committees;Area;Cancer Center;cancer clinical trial;Cancer Hospital;cancer therapy;cancer type;Catchment Area;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Comprehensive Cancer Center;Conduct Clinical Trials;Data;Dedications;Descriptor;Development;Doctor of Philosophy;Ensure;experience;Faculty;frontier;Funding;Goals;Grant;Growth;Huntsman Cancer Institute at the University of Utah;Idaho;Image;Infrastructure;innovation;Lead;Leadership;Malignant Neoplasms;Medical;Medical Records;member;Montana;Multi-Institutional Clinical Trial;National Cancer Institute;National Clinical Trials Network;Native American population;Native American Tribe;Nevada;Oncology;operation;outreach;participant enrollment;Patient Care;patient population;Patients;Population;population based;Population Database;Principal Investigator;programs;Qualifying;quantitative imaging;Radiation Oncologist;rare cancer;Rare Diseases;Recording of previous events;Records;Research;Research Infrastructure;Research Personnel;Resources;Rural;rural Americans;Site;Southwest Oncology Group;success;Therapeutic;Therapeutic Trials;Underserved Population;United States;Universities;Utah;Vision;Work;Wyoming

PROJECT_TITLE: Huntsman Cancer Institute/ University of Utah Network Lead Academic Participating Site Application


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: In spite of advances due to anti-retroviral therapy and rationally designed therapies AIDS-associated Kaposi’ sarcoma continues to be a global health problem affecting many HIV at-risk populations. It is caused by human cancer causing-virus the Kaposi’s sarcoma herpesvirus that can infect and transform human. Research on the molecular and cellular mechanisms whereby the KSHV virus causes KS, will aid our understanding of this viral disease and help design and test therapies.

PI_NAMEs: SHEMBADE, NOULA DATTU (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS therapy;antiretroviral therapy;Binding;Bypass;Cancer Etiology;Cells;Clinical;Compensation;Complex;design;Development;Disease;Environment;Feedback;FRAP1 gene;Genes;Genetic;global health;HIF1A gene;HIV;Human;Human Herpesvirus 8;Hypoxia;Imatinib;improved;In Vitro;in vivo Model;Infection;insight;Kaposi Sarcoma;Lytic;Mediating;Mediator;Mesenchymal Stem Cells;Modeling;Molecular;Mus;Natural Immunity;novel therapeutics;Oncogenes;Oncogenic;Outcome;Oxygen;paracrine;Pathogenesis;Pathway interactions;PDGFRA gene;phenotypic biomarker;Phosphotransferases;PIK3CG gene;Platelet-Derived Growth Factor;Populations at Risk;progenitor;Proliferating;Protein Biosynthesis;Proto-Oncogene Proteins c-akt;rational design;recruit;Regulation;repository;Research;Resistance;RNA Cap-Binding Proteins;Role;Sampling;Signal Transduction;Stress;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy design;Tissues;Translation Initiation;Translational Activation;Translations;tumor;tumorigenesis;Up-Regulation;Viral;Viral Oncogene;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Interplay between PDGFRA, oxygen-regulated translation and KSHV in Kaposi's sarcomagenesis


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: DURHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative -- The Duke Population Research Center (DPRC) provides an adaptive scientific infrastructure to promote the collaborative, interdisciplinary study of the trajectories of healthy child development and lifelong health, by bringing together scientists from multiple disciplines, who are interested in the frameworks for measurement, classification and data collection which are anchored in the core concepts of demography and population sciences.

PI_NAMEs: MERLI, GIOVANNA M (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Acceleration;aging population;Applications Grants;Area;Award;Behavioral Sciences;Big Data;big data management;Biological;career;Centers for Population Health;Child Development;Childhood;Classification;cohort;Collaborations;Collection;Communication;Complex Analysis;Computing Methodologies;computing resources;cost;cost effective;Data;data access;Data Analyses;Data Collection;data curation;data resource;Data Sources;Demography;Development;digital;Discipline;Educational workshop;experience;Extramural Activities;Faculty;Foundations;Free Will;Funding;Funding Opportunities;Generations;Goals;Government;Grant;Health;Health Sciences;health training;high reward;high risk;Human;Human Development;Informatics;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Investments;Life;Life Cycle Stages;Link;Maps;Measurement;Mentors;Modeling;multidisciplinary;National Institute of Child Health and Human Development;next generation;Outcome;Pathway Analysis;Personal Satisfaction;Policies;Population;Population Dynamics;population health;Population Research;Population Sciences;Population Study;post-doctoral training;pre-doctoral;Primates;Process;Productivity;programs;recruit;Request for Applications;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Resources;response;Sampling;scale up;Science;Scientist;Secure;Services;social;Social Network;Social Sciences;Societies;Students;synergism;System;Testing;tool;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Duke Population Research Center


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

PROJECT_TERMS: Adopted;Aging;aging population;Ally;Applications Grants;Audience Research;Award;benefit sharing;career;Centers for Population Health;cohesion;Communication;Communities;computerized tools;computing resources;Cost Control;cost effective;Cost Sharing;Databases;Dedications;Development;Effectiveness;Enhancement Technology;Ensure;Eye;Faculty;flexibility;Fostering;Foundations;Funding;Goals;Grant;Incentives;Informatics;informatics infrastructure;innovation;Investments;Leadership;meetings;member;Monitor;new technology;opportunity cost;Persons;Population;Population Research;Population Sciences;Postdoctoral Fellow;Process;Productivity;programs;Reporting;Research;research and development;Research Personnel;Resources;Science;Scientist;Series;Services;skills;sound;stem;Students;synergism;tool;Training;Universities;virtual;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research

PI_NAMEs: MOODY, JAMES  (contact)

PROJECT_TERMS: Acceleration;aging population;Ally;Area;Award;career;catalyst;Centers for Population Health;Classification;Collaborations;Connective Tissue;Data;Data Analytics;Data Collection;Demography;Development;Discipline;Educational workshop;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Government;Grant;Growth;Health;improved;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Investments;Knowledge;Lead;Measurement;medical specialties;Mentors;Methods;Modeling;National Institute of Child Health and Human Development;next generation;novel;Policies;Population;Population Dynamics;population health;Population Research;Population Sciences;Population Study;Productivity;Professional Organizations;programs;Publications;Research;research and development;Research Personnel;Resources;response;Running;Science;Scientist;Series;Services;social;Social Network;Societies;symposium;System;Testing;Work;working group;Writing

PROJECT_TITLE: Development Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Simultaneous replication and transcription of the same DNA template leads to collisions between the replication and transcription machineries, and to the incorporation of large numbers of ribonucleotides into the genome – both of which may be a significant source of DNA damage in eukaryotes. One project will characterize the mechanisms through which two nuclear RNA polymerases responsible for transcription – RNAP2 and RNAP3 – impede replication, and the molecular basis for DNA damage at conflict sites. The other project investigates how ribonucleotides mis-incorporated during DNA replication impact genome structure and function, and how they are repaired.

PI_NAMEs: SMITH, DUNCAN J (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Biochemistry;Biological Assay;Biological Process;Cell division;Cells;Chromatin;Chromatin Structure;Conflict (Psychology);Discrimination;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Enzymes;Etiology;Eukaryota;Eukaryotic Cell;Excision;Excision Repair;Genetic;Genetic Transcription;Genome;genome integrity;genome-wide;Genomic Instability;Higher Order Chromatin Structure;Human;human disease;Impairment;In Vitro;insight;Lesion;Link;Maps;Methods;Modeling;Molecular;Movement;novel;Nuclear RNA;Nucleosomes;Pathway interactions;pseudotoxoplasmosis syndrome;Rare Diseases;repaired;Resolution;Ribonucleases;Ribonucleosides;Ribonucleotides;RNA;Saccharomyces cerevisiae;Saccharomycetales;Site;Source;Structure;tripolyphosphate;tumor progression;Work

PROJECT_TITLE: Dissecting the impact of RNA on DNA replication and chromatin structure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DE ALMEIDA RANGEL, MARCOS  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;analytical tool;Archives;Area;Big Data;Bioinformatics;Code;Cohort Studies;Complex;complex data;computer infrastructure;Computer software;computing resources;cost effective;Country;County;Data;data access;Data Analyses;Data Analytics;Data Collection;data infrastructure;data integration;data management;Data Protection;Data Sources;design;Development;digital;econometrics;Ensure;Environment;Ethics;ethnic diversity;evidence base;Face;Faculty;flexibility;Funding;Goals;Government Agencies;Growth;Health;Health Sciences;Healthcare;improved;Information Sciences;Information Systems;Information Technology;Infrastructure;innovation;Institution;Institutional Review Boards;interest;Internet;Intervention;Investments;Legal;Link;Local Government;Location;Methods;Modeling;new technology;North Carolina;novel strategies;online resource;Online Systems;Personal Satisfaction;Policies;Policy Making;Population;Population Analysis;Population Dynamics;population health;Population Heterogeneity;Population Research;Population Sciences;Population Sizes;Privatization;Procedures;programs;Protocols documentation;racial diversity;Records;Reproducibility;Research;Research Institute;Research Personnel;Research Support;Resources;Sampling;Science;Secure;Security;Services;simulation;Site;social;social science research;Students;synergism;task analysis;Techniques;Technology;Testing;Time;tool;Training;United States National Institutes of Health;Universities;Vendor;Vertebral column;Work

PROJECT_TITLE: Science Core


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Stuttering is a neurodevelopmental disorder with profound consequences for communication and quality of life. This project will take an innovative multimodal neuroimaging approach to elucidate speech sound processing in children who stutter by combining neurophysiological, functional magnetic resonance imaging, and systems- level computational modeling approaches. A mechanistic understanding of speech sound processing and the ways in which these processes are modulated by task demands will facilitate future development of neurobiologically informed stuttering interventions that target specific neural deficits in children who stutter.

PI_NAMEs: HAMPTON WRAY, AMANDA M (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;aged;Attention;attentional modulation;Auditory;Auditory area;Behavioral;Categories;Child;Childhood;Cognitive;cognitive neuroscience;collaborative environment;Communication;Complex;Comprehension;Computer Models;Data;Data Set;Development;Developmental Stuttering;directed attention;Disfluent;Electroencephalography;Environment;Event-Related Potentials;experience;Frequencies;Functional Magnetic Resonance Imaging;Future;Grain;Inferior frontal gyrus;innovation;Intervention;Left;Linguistics;Machine Learning;Measures;Mediating;Methods;millisecond;Modeling;Motor;Motor Cortex;multimodal neuroimaging;neural;neural network;Neurobiology;Neurodevelopmental Disorder;neuroimaging;neurophysiology;Participant;Pattern;peer;Perception;Phonetics;Physiological;Process;Production;Psychophysiology;Quality of life;Research Personnel;Resources;response;Sensory;Signal Transduction;Speech;speech processing;Speech Sound;Stimulus;Stuttering;Subgroup;System;Task Performances;temporal measurement;Work

PROJECT_TITLE: Neural Processing of Speech Signals in Children Who Stutter


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Stroke;Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Ischemic stroke and spinal cord injury are leading causes of chronic disability world-wide. Recent evidence suggests peripheral motoneurons and skeletal muscle are remodeled following central nervous system injury and identifies an understudied area for therapeutic development. This project will investigate how central nervous system injury impacts the neuromuscular system and how the associated mechanisms of disability can be targeted using gene therapy to facilitate functional recovery.

PI_NAMEs: BALCH, MARIA HELEN HARLEY (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Affect;Aging;Applications Grants;Area;Axon;Behavioral;Brain Infarction;Brain-Derived Neurotrophic Factor;career;career development;Central Nervous System;central nervous system injury;Chronic;Chronic disability;Clinical;Clinical Research;clinically relevant;combat;Communication;Confocal Microscopy;Data;Development;disability;disability burden;Disease;Electrophysiology (science);Environment;Etiology;Event;Exhibits;experience;Faculty;Fellowship;Fostering;Functional disorder;Future;gene therapy;Growth;Health;hemiparesis;Histologic;Histopathology;Horns;Immunohistochemistry;in vivo;Investigation;Ischemia;Ischemic Stroke;Lesion;Link;Longitudinal Studies;Measures;Mediating;Mediator;Mentors;Mentorship;Methodology;Molecular;Molecular Biology Techniques;Morphology;Motor;motor behavior;motor control;motor disorder;motor impairment;Motor Neurons;Motor output;mouse model;Muscle;Muscle Fibers;Muscle function;Nerve Degeneration;nerve supply;Nervous System Trauma;Neurologic;neurological rehabilitation;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;neuromuscular system;Neurons;novel;Ohio;overexpression;Paralysed;Paresis;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Physicians;Physiology;Positioning Attribute;post stroke;pre-clinical;preclinical study;Prevalence;Quadriplegia;Recovery;Recovery of Function;recruit;Reporting;Research;Resources;response;Role;Scientist;Signal Transduction;Skeletal Muscle;Specialist;Spinal cord injury;Spinal cord injury patients;Stroke;stroke model;stroke survivor;Synapses;Testing;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;Thinness;Tissue Banks;Training;training opportunity;Trans-Synaptic Degeneration;transcriptome;transmission process;Universities;Viral;Work;years lived with disability

PROJECT_TITLE: Maladaptive Remodeling of the Neuromuscular Synapse Following Central Nervous System Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE People with type 1 diabetes suffer chronic complications and are at risk of life-threatening episodes of hypoglycemia and diabetic ketoacidosis. Therapies that increase the number of residual β-cells have been proposed as a strategy to delay or reverse insulin dependence in people with prediabetes or in the “honeymoon” phase of the disease. This research will address whether changes to β-cell metabolism impact the effectiveness of such therapies, opening the possibility for combined drug and dietary interventions to prevent or reverse disease progression.

PI_NAMEs: WORTHAM, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acetyl Coenzyme A;Affect;Area;ATP Citrate (pro-S)-Lyase;autoimmune pathogenesis;Autoimmunity;Beta Cell;Biological Assay;Blood Glucose;Cell Count;Cell Cycle;Cell division;Cell Physiology;Cell Proliferation;cell regeneration;Cellular Metabolic Process;ChIP-seq;Chronic;Citrates;Coupled;Couples;Data;Dependence;Diabetes Mellitus;diabetes mellitus therapy;Diabetic Ketoacidosis;Dietary Intervention;Disease;Disease Progression;Down-Regulation;Drug Combinations;Effectiveness;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;experimental study;Exposure to;gene synthesis;Genetic;Genetic Transcription;Genomics;Glucose;glucose metabolism;Goals;Histone Acetylation;histone methylation;histone modification;Human;Hypoglycemia;Immunology;immunoregulation;Impairment;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Life;Link;lipid metabolism;Lipid Synthesis Pathway;Lipids;Malignant Neoplasms;Maps;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;mitochondrial metabolism;Mitogens;model building;Modification;Monitor;Nutrient;Pancreas;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;pre-clinical;preclinical development;Prediabetes syndrome;preservation;prevent;Production;programs;Proliferating;regenerative therapy;Regulation;Regulatory Element;Research;Residual state;Resources;response;Risk;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;Stimulation of Cell Proliferation;Structure of beta Cell of islet;Supporting Cell;Testing;Therapeutic;therapy development;Time

PROJECT_TITLE: Metabolic requirements of pancreatic beta cell proliferation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Staphylococcus aureus poses a significant health burden, thwarting novel drug development, defying hospital infection prevention practices, and circumventing public health measures. The successful development of a universal vaccine will afford the only durable solution to S. aureus infection at a population level. The proposed research will investigate the human adaptive immune response to S. aureus as a function of development and S. aureus exposure in infancy and early childhood and will ultimately inform the approach to vaccine design and implementation.

PI_NAMEs: BUBECK WARDENBURG, JULIANE  (contact);FRITZ, STEPHANIE ANN

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Active Immunization;adaptive immune response;adaptive immunity;Address;Adult;Age;alpha Toxin;Animals;Antibiotic Resistance;Antibodies;Antibody Response;antigen-specific T cells;Antigens;antimicrobial;Antimicrobial Resistance;B-Lymphocytes;biobank;burden of illness;Cell Differentiation process;Cessation of life;Child;Childhood;Clinical;Clinical Trials;cohort;Communicable Diseases;comparative;Complex;Coupled;Critical Illness;Cytometry;Data;design;Development;Disease;drug development;Drug resistance;early childhood;Economic Burden;Economics;Epidemic;Epidemiology;Evaluation;Exotoxins;Exposure to;Failure;falls;Foundations;Generations;Genus staphylococcus;Glean;Health;high dimensionality;high risk population;Hospitals;Human;Immune response;Immunity;Individual;infancy;Infant;Infection;Infectious disease threat;insight;interest;Investments;Knowledge;Life;Light;Maternally-Acquired Immunity;Measures;Mediating;Medical;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Multi-Drug Resistance;multidisciplinary;Nosocomial Infections;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Organism;Pathogenesis;pathogenic bacteria;patient population;Patients;pharmacologic;Phase III Clinical Trials;Phenotype;Pneumonia;Population;Positioning Attribute;Preparation;preservation;prevent;prevention practice;Public Health;receptor;Recording of previous events;Recurrence;Research;Research Personnel;resistant strain;response;Role;Sepsis;Serology;Shapes;Specificity;Staphylococcus aureus;Staphylococcus aureus infection;success;System;T cell response;T-Cell Development;T-cell diversity;T-Lymphocyte;Therapeutic;Toxin;universal vaccine;Vaccination;Vaccine Antigen;Vaccine Design;vaccine development;Vaccines;Virulence Factors

PROJECT_TITLE: Development of human adaptive immunity to Staphylococcus aureus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(02)M]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Immunization;Immunotherapy;Infectious Diseases;Malaria;Malaria Vaccine;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Malaria is still a major cause of death partially because we do not understand how antibodies protect. We recently found that natural killer (NK) cells could kill infected RBCs via antibody mediated cellular cytotoxicity (ADCC), and in an endemic malaria cohort, specific NK cells enhanced for ADCC activity correlated with decreased parasitemia and protection from malaria. This proposal builds on our findings to understand how these specific NK cells form and function, as well as understand how antibodies function to protect humans from malaria with the hope to improve vaccine design and efficacy readouts.

PI_NAMEs: HART, GEOFFREY T (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Ablation;Adherence;Adhesions;Affect;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antibody-mediated protection;Binding;Biological Assay;Cause of Death;CD3 Antigens;Cell Adhesion Molecules;Cell Nucleus;Cessation of life;child bearing;Chondroitin Sulfate A;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;CRISPR/Cas technology;cytokine;Cytokine Signaling;Data;design;Development;Effector Cell;Engineering;Fc Receptor;FCGR3B gene;Frequencies;Future;granulysin;Granzyme;Growth;Human;human monoclonal antibodies;Immunization;Immunize;Immunotherapy;improved;In Vitro;Individual;Induction of Apoptosis;Infection;insight;Invaded;Label;Malaria;malaria infection;Malaria Vaccines;Mediating;Membrane Proteins;men;Monkeys;Monoclonal Antibodies;Natural Killer Cells;Nature;Necrosis;Nitric Oxide;novel;Parasitemia;Parasites;perforin;Placenta;placental malaria;Plasma;Plasmodium;Pregnancy;Pregnancy Outcome;programs;Proliferating;Protein Isoforms;Proteins;response;Role;Sampling;Signal Transduction;Spontaneous abortion;Surface;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic antibodies;tool;transcription factor;Vaccination;Vaccine Design;vaccine efficacy;Vaccines;Woman;ZAP-70 Gene;ZNF145 gene

PROJECT_TITLE: The role of natural killer cells and antibodies in protection from malaria

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  We will elucidate the tumor ecosystems that drive response to treatments in specific cancers. This project will integrate single cell and bulk expression datasets with clinical information from cancer patients. We will validate findings for their clinical utility using high-content imaging in archival tissues.

PI_NAMEs: GENTLES, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Architecture;Atlas of Cancer Mortality in the United States;Awareness;Biological Markers;biomarker identification;Biopsy;Cancer Patient;cancer type;Carcinoma;cell behavior;cell type;Cells;cellular imaging;Clinical;cohort;Computer Analysis;computer framework;Custom;cytotoxic;Data;Data Set;Disease Resistance;Ecosystem;Environment;Exclusion;exhaust;experience;Future;Gene Expression;Genes;Genetic Transcription;human tissue;Image;Immune;Immunotherapy;in vivo evaluation;Infiltration;Inflammatory;innovation;Knowledge;Learning;Malignant neoplasm of ovary;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Melanoma;Meta-Analysis;Methods;Methylation;Modeling;new therapeutic target;Non-Small-Cell Lung Carcinoma;Outcome;Patients;Phenotype;Population;potential biomarker;Process;Prognosis;prognostic;programs;Regulation;Relapse;research clinical testing;Research Personnel;Resistance;response;Sampling;Serous;sex;Sex Differences;Signal Transduction;single-cell RNA sequencing;Solid Carcinoma;Stains;success;survival outcome;T-Lymphocyte;targeted cancer therapy;Testing;The Cancer Genome Atlas;therapeutic target;Tissue Microarray;Tissues;transcriptome sequencing;Treatment outcome;treatment response;tumor;women versus men;Work

PROJECT_TITLE: Computational analysis of tumor ecosystems and their regulation and association with outcomes

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Animals interpret complex sensory environments using both instinct and memories of past experiences. In- stinctual odor processing occurs in a region of the brain where the inborn structure of connections among neurons generates meaning, while learned processing occurs in a separate brain area where unstructured neuronal connections gain meaning through experience This project explores how neurons make unpre- dictable connections with one another during the development of an olfactory learning center in the fruit fly brain.

PI_NAMEs: CLOWNEY, ELEANOR JOSEPHINE (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Generation and manipulation of combinatorial connectivity in olfactory perception

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Complementary and Integrative Health;Physical Activity;Physical Rehabilitation;Prevention;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Peripheral artery disease occurs when impaired blood flow to the tissue results in pain, decreased mobility, amputations, and increased mortality. Supervised exercise is one of the most effective treatments at improving patient’s quality of life, yet the mechanisms for how it works are not well understood. This proposal investigates satellite cells, a muscle stem cell, as the potential mediator of this process and understanding changes in the satellite cell’s biology with exercise will allow us to develop better therapies to treat the disease.

PI_NAMEs: HANSEN, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Ablation;Affect;Aftercare;American;Amputation;Animals;Anti-Hypertensive Agents;Area;Arterial Fatty Streak;Automobile Driving;Biological;Biology;Blood flow;Blood Platelets;Blood Vessels;Cardiovascular system;Cell Count;cell motility;Cells;Cellular biology;claudication;Clinical;cost;Cre lox recombination system;cytokine;Cytokine Signaling;Data;density;Development;Disease;Disease Progression;effective therapy;evidence base;Exercise;exercise intervention;exercise program;exercise regimen;Exercise Therapy;exercise training;functional improvement;Gene Expression Profile;Genetic Transcription;Goals;Growth;Growth Factor;Health;Heterogeneity;histological stains;Human;human tissue;Hypoxia;Impairment;improved;In Vitro;in vivo;inducible Cre;Ischemia;Lactic acid;limb ischemia;Limb structure;Mediating;Mediator;Medical;migration;Mobility decline;Modeling;mortality;mouse model;Mus;Muscle;muscle physiology;muscle progenitor cell;Muscle satellite cell;Nature;non-healing wounds;novel;Operative Surgical Procedures;Pain;Paracrine Communication;Pathology;Patient Isolation;patient response;Patient-Focused Outcomes;Patients;Perfusion;Peripheral arterial disease;Persons;Phenotype;Play;Population;preconditioning;prevent;Process;programs;Proliferating;Proteins;Quality of life;Recommendation;Recovery;repaired;Reporting;Research;Research Priority;response;response to injury;Risk Factors;Role;Running;Sampling;single cell sequencing;single-cell RNA sequencing;Skeletal Muscle;Skeletal Muscle Satellite Cells;Stimulus;Symptoms;Tamoxifen;Testing;Therapeutic;Tissue Sample;Tissues;treatment strategy;Vasculogenic;Walking;Work

PROJECT_TITLE: Heterogeneity of Satellite Cell Populations Play a Role in Improvements in PAD after Exercise Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Genetics;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Chronic respiratory disease is a major public health issue that may arise from perinatal environmental metals, a research area that has not been well studied. We will use innovative metal exposure measures in deciduous teeth to determine early life critical windows when lung growth trajectories are susceptible to environmental metals and their mixtures. We will also assess mitochondrial DNA heteroplasmy in nasal epithelium to quantify cumulative oxidative stress, a proposed mechanism underlying our findings.

PI_NAMEs: ROSA, MARIA JOSE (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 16 year old;Ablation;Accounting;Address;Adolescence;Adult;Affect;age related decline;aged;airway epithelium;Animals;Archives;Area;Arsenic;Biological Markers;Birth;Bronchodilator Agents;burden of illness;Cadmium;Cells;Child;Childhood;chronic respiratory disease;Cities;cohort;cost;cost effective;Data;deciduous tooth;Development;Developmental Process;Disease;disorder risk;DNA Damage;Dose;Early identification;early life exposure;Environment;Epithelial Cells;Epithelium;Exposure to;Family;fetal;functional decline;global health;Goals;Growth;Growth and Development function;Health;Health Benefit;Health Care Costs;heteroplasmy;Impairment;improved;in utero;Individual;Inductively Coupled Plasma Mass Spectrometry;infancy;Inflammation;Infrastructure;innovation;Intervention;Lasers;late life;Lead;lead exposure;Life;Life Cycle Stages;Link;Longitudinal Studies;longitudinal, prospective study;Lung;lung development;Lung Diseases;lung health;Manganese;Measures;Mediating;Mediation;Mediator;Metal exposure;Metals;Mexico;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;Modeling;Molecular;Morbidity - disease rate;mortality;Motion;Nasal Epithelium;Nose;novel;Obesity;oxidative damage;Oxidative Stress;Pattern;Perinatal;perinatal environment;Perinatal Exposure;Persons;Phenotype;Play;Predisposition;Pregnancy;prenatal;prenatal exposure;Prevalence;prevent;Prevention strategy;prospective;Prospective cohort;Prospective Studies;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Reactive Oxygen Species;Research;Respiratory Disease;respiratory health;Respiratory System;response;Risk;Risk Factors;Risk Reduction;Role;social stressor;Source;Spirometry;Structure;temporal measurement;Time;time interval;Tissues;Tooth structure;toxic metal;treatment strategy;Vital capacity

PROJECT_TITLE: Effect of Perinatal Exposure to Metals on Lung Function Trajectories and Mitochondrial DNA Heteroplasmy from Childhood to Adolescence

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Retinitis pigmentosa (RP), a hereditary retinal degeneration, is characterized by loss of rod photoreceptors and often leads to loss of vision greatly affecting the quality of life for the 1 in every 3000 individuals who are affected. Our proposed studies on RP mouse models of RP59 will provide important new insights into disease pathology and could lead to treatments for this blinding disorder.

PI_NAMEs: NGUYEN, MAI N (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 1p36;Affect;Alleles;Anatomy;Animal Model;autosome;Biochemical;Biochemical Pathway;Blindness;Cells;Chromosomes;Classification;Clinical;Congenital disorders of glycosylation;CRISPR/Cas technology;Data;Diphosphates;Disease;Electroretinography;Exons;expectation;Functional disorder;gene editing technology;Genes;Glial Fibrillary Acidic Protein;glycosylation;Hereditary Disease;Heterozygote;Human;Immunohistochemistry;Individual;Inherited;inorganic phosphate;insight;Intervention;Knock-in;Knock-in Mouse;light microscopy;Link;loss of function;Measurement;Missense Mutation;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;novel;Online Mendelian Inheritance In Man;outer plexiform layer;Pathology;Patients;Phenotype;Photoreceptors;Physiological;Physiology;Point Mutation;Pre-Clinical Model;Preclinical Testing;prenyl;Protein Glycosylation;Proteins;Publishing;Quality of life;Recovery;Reporting;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;retinal rods;Retinitis Pigmentosa;Severity of illness;Synapses;Synaptic Transmission;Up-Regulation

PROJECT_TITLE: Characterization of DHDDS RP59 Knockin Models of Retinitis Pigmentosa


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Tertiary lymphoid structures (TLS) are ectopic disorganized lymphoid aggregates recognized as a pathologic hallmark in IBD. The overall goal of this proposal is to unravel the mechanisms that drive TLS formation and function in mouse models of IBD by targeting differentiation and function of mucosa-resident (CX3CR1hi) Ms shown to induce TLS.

PI_NAMEs: BOGUNOVIC, MILENA  (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: Affect;Anti-Tumor Necrosis Factor Therapy;Antigen Presentation;Antigen-Presenting Cells;Automobile Driving;B-Cell Activation;Biological Products;Cells;Chronic;Clinical;Colitis;Colon;Communication;Crohn's disease;Cytokine Network Pathway;Data;Dendritic Cells;Development;dimensional analysis;Epithelial Cells;Genetic;Genetic Transcription;Goals;Heterogeneity;Human;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Incidence;Infectious colitis;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-10;Interleukin-4;Intestinal Mucosa;Intestines;Lesion;Lymphoid;Macrophage;Mediator;Modeling;Mononuclear;mouse model;Mucous Membrane;murine colitis;Mus;novel;Outcome;pathobiont;pathogen;Pathogenesis;Pathogenicity;Pathologic;Patients;Phagocytes;Play;potential biomarker;Prevalence;prevent;Production;Publishing;Regulation;Resistance;response;Role;Salmonella;salmonella colitis;Signal Transduction;spatiotemporal;Stromal Cells;Structure;T cell differentiation;T-Lymphocyte;tertiary lymphoid organ;Testing;therapeutic target;Time;TNF gene;Transgenic Mice;Tumor Necrosis Factor Receptor;Ulcerative Colitis

PROJECT_TITLE: Mucosal Macrophages and Tertiary Lymphoid Structures in IBD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Mtb-specific Th1 cells alone do not predict protection against tuberculosis (TB), suggesting that although Th1 cells are required for controlling Mtb replication, other types of immune cells may be needed to prevent infection and eradicate the bacteria. We recently found a distinct subset of CD4+ T cells, IL-9-producing CD4+ T cells (Th9), can mediate protective immunity against Mtb infection, and therefore propose in this application to investigate the effects of Mtb-specific Th9 cells on protective TB immunity; define the roles of IL-9 in vaccine-induced protection against Mtb infection; identify the source for IL-9 in PBMC and BAL cells from BCG vaccinated individuals, the influence and mechanisms of Mtb-specific Th9 cells on bacterial growth in human macrophages. These studies will have a significant impact on improving our understanding of host protective immune mechanisms against Mtb infection, and provide the rationale for targeting Mtb-specific Th9 cells as a new strategy for more effective TB vaccines and/or immunotherapies against Mtb infection.

PI_NAMEs: HOFT, DANIEL F. (contact);LIU, JIANGUO

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adoptive Transfer;Affect;Allergic Reaction;Bacille Calmette-Guerin vaccination;Bacteria;BCG Vaccine;Blood;Bronchoalveolar Lavage;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Coculture Techniques;cytokine;Data;Development;Disease;Genes;Genetically Engineered Mouse;Growth;healthy volunteer;Helminths;Human;human subject;Immune;Immunity;Immunotherapy;improved;in vivo;indicated prevention;Infection prevention;Inflammation;Inflammatory;Interferons;Interleukin-4;Interleukin-9;Intravenous;Knockout Mice;Lung;Macaca;Macrophage;Mediating;Memory;Messenger RNA;Monocyte Chemoattractant Proteins;Mucous Membrane;Mus;mycobacterial;Mycobacterium tuberculosis;novel;novel therapeutics;novel vaccines;Oral;Parasites;Patients;Peripheral Blood Mononuclear Cell;Persons;Play;Production;protective effect;Proteins;Recombinants;Reporter;Reporting;response;RNA-Binding Proteins;Role;Route;Sampling;Source;T-Cell Activation;Testing;Th1 Cells;transcriptome;Transforming Growth Factor beta;Transgenic Mice;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Tumor Immunity;Vaccinated;vaccine-induced immunity;Vaccinee;Vaccines

PROJECT_TITLE: Th9 cells and protective TB immunity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE The goal of this basic science proposal is to answer fundamental questions about how brain networks interact during the course of navigational learning. We are interested in how active decision making during learning offers an advantage compared to passive guidance, particularly when it comes to learning the path connections between locations. Our focus is the prefrontal-hippocampal-striatal (PHS) circuit, which is particularly relevant to mental disorders involving reinforcement and reward learning, including depression, Parkinson’s Disease, drug addiction, obsessive compulsive disorder, and attention deficit/hyperactivity disorder.

PI_NAMEs: CHRASTIL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Animal Model;Area;Attention deficit hyperactivity disorder;Basic Science;Behavior;Behavioral;Brain;Brain imaging;Clinical;Cognitive;Communication;Communities;comparative;Complex;computational basis;Corpus striatum structure;Dangerousness;Decision Making;Disease;Disorientation;Drug Addiction;educational atmosphere;entorhinal cortex;Environment;Episodic memory;experience;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Graph;graph learning;Hippocampus;Home;Human;insight;interest;Intuition;Investigation;Knowledge;knowledge graph;Learning;Link;Location;Major Depressive Disorder;Maps;medial temporal lobe;member;Memory;Mental Depression;Mental disorders;Methods;Modeling;Modeling of Functional Interactions;network models;neural;novel;Obsessive-Compulsive Disorder;Organism;Outcome;Parkinson Disease;Pathway interactions;Pattern;Peripheral;Persons;Population;Process;Psychological reinforcement;Research;Research Proposals;Resources;Rewards;Risk;Route;spatial memory;Structure;Subway;support network;Surveys;Techniques;Testing;Theoretical model;Time;virtual reality;way finding;young adult

PROJECT_TITLE: Navigational learning and memory: Cognitive graphs, active decision making, and brain network dynamics

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Inflammatory bowel diseases (IBD) affect nearly 1.5 million people in the US alone. Since many aspects of the disease pathology are not entirely understood, it is no surprise that many patients either do not respond to symptom-focused therapies or suffer a relapse of the disease after initial success. This proposal focuses on an unexplored facet of IBD: the contribution of nitric oxide generated by gut microbiota as a contributor to the pathophysiology of these diseases in the host, and may identify novel therapeutic targets and treatment strategies for IBD.

PI_NAMEs: SETH, PUNEET ;STAMLER, JONATHAN S. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Affect;Aminoquinolines;Atlases;Bacteria;Biological Models;Biological Process;Blood;Blood Circulation;Brain;Caenorhabditis elegans;Communication;Crohn's disease;Cysteine;Diagnosis;Disease;Disease Progression;Distant;Drug Targeting;dysbiosis;Etiology;Foundations;Frequencies;Functional disorder;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;Glutathione;Goals;gut bacteria;gut microbes;gut microbiota;Health;Heart;Hemoglobin;host microbiota;Human;Human body;human disease;Human Microbiome;human model;Inflammatory Bowel Diseases;inhibitor;interspecies communication;intestinal homeostasis;Investigation;Kidney;Knock-in Mouse;Knock-out;Language;Liver;Lung;Mammals;Mediating;Microbe;microbial;microbiome;microbiota;Modeling;mouse model;Mus;Nematoda;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;novel;Organ;Organism;overexpression;Pathology;Pathway interactions;Patients;Persons;Physiological;Physiology;Plasma;Play;Post-Translational Protein Processing;Probiotics;Production;protein function;Protein S;Proteins;Proteome;Publishing;Recurrent disease;Regulation;Risk Factors;Role;S-Nitrosothiols;Set protein;Signal Transduction;Signaling Molecule;success;Sulfhydryl Compounds;Sum;Symptoms;Terminal Ileitis;Testing;Time;Tissues;treatment strategy;Ulcerative Colitis;Work

PROJECT_TITLE: Gut Microbe-Derived Nitric Oxide As A Signal To Host: Role In Normal Physiology And In Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(02)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Congenital heart disease (CHD) affects 1% of live births, with one quarter of cases requiring surgical correction in the first year of life. More than 75% of CHD patients receive off-label cardiovascular medications to manage postoperative arrhythmias and low cardiac output. We will investigate the impact of myocardial immaturity on cardiac drug responsiveness, using both large animal models and cardiac tissue procured from CHD patients.

PI_NAMEs: POSNACK, NIKKI GILLUM (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Address;Adolescent;Adrenergic Agents;Adrenergic beta-Antagonists;Adrenergic Receptor;Adult;Adverse effects;Affect;Age;age group;age related;Amiodarone;Anatomy;Animal Model;Animals;Anti-Arrhythmia Agents;Architecture;Arrhythmia;Biophysics;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;cardiogenesis;Cardiology;Cardiopulmonary Bypass;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular system;channel blockers;Child;Childhood;Clinical;clinical care;Clinical Research;Computer Models;Congenital Abnormality;congenital heart abnormality;Data;Depressed mood;Development;Disease;Dopamine;Dose;Drug Design;drug efficacy;Drug Prescriptions;Drug Targeting;drug testing;Edema;Electrolytes;Electrophysiology (science);Environment;Epinephrine;esmolol;experience;fetus hypoxia;Genetic Transcription;Goals;Heart;Heart failure;Human;Hypotension;Hypoxia;Infant;Inflammation;innovation;Ion Channel;Knowledge;Label;Lesion;Life;Live Birth;Low Cardiac Output;Maps;mathematical model;Measurement;Mechanics;Metabolic;Methods;Mind;Modeling;Muscle;Myocardial;Myocardium;Neonatal;neonate;Nodal;off-label drug;Operative Surgical Procedures;Optics;Outcome;Oxygen;Patients;Pediatric cardiology;pediatric patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;Physiology;Population;postnatal;postnatal development;Postoperative Period;preclinical study;Process;Proteomics;receptor density;Regimen;repaired;Reporting;response;Safety;System;Techniques;Testing;therapy design;Tissue Procurements;Tissues;transcriptomics;Underrepresented Populations;voltage;Work

PROJECT_TITLE: Off-label drugs in cardiology: evaluating age- and disease-appropriate therapies


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Cancer associated rearrangements of the ROS1 gene produce oncogenic ROS1 fusion proteins that aggressively drive tumor growth, and are actionable with targeted pharmaceutical agents. Some tumors have ROS1 mutations that are another type of cancer-associated genetic aberration, but the impact of these mutations on ROS1 function or its contribution to tumor growth is currently unknown. Our goal is to rigorously characterize ROS1 and its functions in cancer, as this may pinpoint additional biomarkers of drug-sensitivity, and potentially expand the benefit of ROS1 targeted therapy in the future.

PI_NAMEs: DAVARE, MONIKA A (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Biochemical;Biological;Biological Markers;Biological Models;cancer genome;cancer genomics;cancer type;Catalysis;cDNA Expression;Cell model;cell transformation;Chimeric Proteins;Chromosomal Rearrangement;clinical translation;combinatorial;CRISPR/Cas technology;crizotinib;Data;Development;Disease;Down-Regulation;drug sensitivity;Eligibility Determination;Engineering;Exhibits;experimental study;Future;gain of function;Genetic;genome editing;genome sequencing;genomic data;Goals;Half-Life;Homeostasis;Human;improved outcome;in silico;In Vitro;in vivo;inhibitor;insight;Intervention;Knowledge;lens;loss of function;Malignant Neoplasms;Maps;Measures;metaplastic cell transformation;Molecular;molecular targeted therapies;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;Neoplasm Metastasis;Neoplastic Cell Transformation;novel;Oncogenes;Oncogenic;Oncoproteins;Orphan;Pathogenesis;Pathogenicity;Patients;Pattern;pharmacologic;Pharmacologic Substance;Phosphotransferases;Physiology;Pilot Projects;Polyubiquitination;Post-Translational Protein Processing;Pre-Clinical Model;protein degradation;Protein Tyrosine Kinase;Proteins;proteostasis;Proto-Oncogenes;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Research;Resistance;response;Role;ROS1 gene;sensor;Signal Transduction;Site;Somatic Mutation;Structure;Structure-Activity Relationship;synergism;targeted treatment;Testing;Therapeutic;Time;trafficking;Translating;translational genomics;Translations;tumor;tumor growth;Tumor Promotion;tumorigenesis;tumorigenic;Tyrosine Kinase Domain;Tyrosine Kinase Inhibitor;Ubiquitination;variant of unknown significance

PROJECT_TITLE: Functional impact, mechanistic role, and targetability of ROS1 aberrations in cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Senescent cells contribute to age related diseases and tissue damage and their experimental elimination ameliorates some clinical symptoms of these conditions. Our proposal aims to identify molecules that are selectively expressed on the surface of senescent cells with the goal of developing chimeric antigen receptor T cells as biological “senolytics” for the treatment of senescence-associated diseases.

PI_NAMEs: LOWE, SCOTT W. (contact);SADELAIN, MICHEL WJ

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Advanced Malignant Neoplasm;advanced system;Age;Age related pathologies;age-related disease;aged;Alzheimer's Disease;antitumor effect;Atherosclerosis;Biological;biological adaptation to stress;Biological Markers;Biological Models;Biology;Cell Adhesion Molecules;Cell Aging;Cell Cycle Arrest;cell growth regulation;Cell secretion;Cell surface;Cell Surface Proteins;cell type;Cells;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;Chromatin;Chronic;Clinical;clinical application;clinically significant;Collaborations;cytokine;Dasatinib;Data;Dependence;Detection;Development;Disease;Drug usage;efficacy evaluation;efficacy testing;Engineering;experimental study;Fibrosis;Gene Activation;gene repression;Genetic Transcription;Goals;Growth Factor;Immune;Immunomodulators;improved;In Vitro;in vivo;innovation;insight;Laboratories;life span;Link;Malignant Neoplasms;Matrix Metalloproteinases;Membrane Proteins;Metalloproteases;Methods;Modality;Modeling;Molecular;Mus;Nature;Nerve Degeneration;NF-kappa B;novel;novel therapeutics;Oncogenes;Organism;Pathology;Pathway interactions;pharmacologic;Plasma;pre-clinical;Pre-Clinical Model;preclinical study;Process;Production;programs;Property;Proteins;Proteomics;Quercetin;Regulation;restoration;Role;selective expression;senescence;senescence associated secretory phenotype;senescent cell;senolytics;side effect;Surface;Symptoms;Technology;Testing;Therapeutic;therapeutic protein;Time;Tissues;tool;Toxic effect;TP53 gene;Transcription Coactivator;transcriptome sequencing;tumor;tumor progression;Tumor Suppressor Proteins;Validation;Work

PROJECT_TITLE: Toward development of senolytic CAR T cells

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative: Bumped-Kinase Inhibitor Drug Development for Toxoplasmosis Toxoplasma gondii infection is devastating in pregnancy and immunocompromised individuals and not addressed well by available therapeutics. This proposal will develop a new therapeutic, a bumped-kinase inhibitor, for use in pregnancy and immunocompromised individuals, by optimizing safety and efficacy.

PI_NAMEs: VAN VOORHIS, WESLEY C (contact)

PROJECT_TERMS: Acute;Address;analog;Animal Model;Animals;Area;Binding Proteins;Biological Assay;Blood;Brain;calcium-dependent protein kinase;Cardiac;Cardiotoxicity;Cardiovascular system;Cells;Central Nervous System;Central Nervous System Infections;Central Nervous System Toxoplasmosis;Characteristics;Chronic;Clinical;congenital infection;Congenital Toxoplasmosis;Cryptosporidiosis;Cyst;design;Development;drug development;Drug Kinetics;Embryonic Development;Enzyme Inhibition;experience;Fetal Death;fetal infection;fetal loss;Fetal Reduction;Fetus;Genes;Goals;Growth;Human;Immune;Immunocompromised Host;improved;In Vitro;in vitro testing;in vivo;Individual;Infection;Infectious Pregnancy Complications;Invaded;kinase inhibitor;Knowledge;Laboratories;Lead;lead candidate;Length;Mammalian Cell;model development;Modeling;mouse model;Mus;novel therapeutics;Outcome;Parasites;Parasitic infection;pathogen;Penetration;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phosphotransferases;placental infection;Plasma Proteins;pre-clinical;Pregnancy;pregnant;Pregnant sheep;Pregnant Women;Property;Proteins;Rattus;Resources;response;Rodent Model;Safety;safety testing;scaffold;scale up;screening;Series;Serology;Sheep;sheep model;Solubility;stillbirth;success;Systemic infection;Testing;Therapeutic;Toll-like receptor 11;Toxic effect;Toxicity Tests;Toxicology;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transmission process;Vertical Transmission;Work;Zebrafish

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Intrinsically disordered proteins and regions (IDPs/IDRs) challenge the structure-function paradigm, taking advantage of their disordered state for functional discrete and large-scale associated interactions with numerous partners. Disorder is enriched in regulatory and disease-linked proteins, such as those involved in autism and cancer. The proposed research will develop and apply state-of-the-art computational and experimental methods to elucidate structural ensembles of IDP/IDR dynamic complexes and biological condensates related to regulation of RNA translation and elasticity. 1

PI_NAMEs: HEAD-GORDON, TERESA L. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Adopted;autism spectrum disorder;Back;Bayesian Modeling;beamline;Binding Proteins;Biological;Biology;C-terminal;Cardiovascular Diseases;Chemicals;Collaborations;Color;Complex;Computer software;computerized tools;Computing Methodologies;Data;Development;Disease;Elasticity;Elastin;Electrostatics;Eukaryotic Initiation Factors;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;frontier;Generations;Grain;Grant;Human;IGFBP2 gene;Inosine Diphosphate;insight;Letters;link protein;Machine Learning;machine learning method;Malignant Neoplasms;Measures;Methods;Modeling;molecular dynamics;monomer;novel;Pathologic;Phase;Phosphorylation;Physical condensation;physical model;Post-Translational Protein Processing;Prevalence;protein folding;protein structure function;Proteins;Proteome;Regulation;Relaxation;Research;Residual state;RNA;Roentgen Rays;Role;Sampling;single molecule;single-molecule FRET;Spectrum Analysis;structural biology;Structure;Surface;three dimensional structure;tool;Translational Regulation;Translations;Tropoelastin;Update;Validation;X-Ray Crystallography

PROJECT_TITLE: Calculating Ensembles of Discrete Dynamic Complexes and Condensed States of Intrinsically Disordered Proteins


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE The specific aims in this proposal are designed to continue our current efforts to maintain a genetically diverse MHC-defined SPF Indian-origin rhesus macaque colony supporting AIDS/HIV-related research focused on the use of opportunistic viral agents as vaccine vectors, and other approaches to AIDS prevention and treatment.

PI_NAMEs: HAERTEL, ANDREW ;MARTIN, LAUREN DREW (contact)

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;AIDS prevention;AIDS vaccine development;Animals;Biomedical Research;Breeding;design;Disease;Ensure;Female;genetic testing;Genetic Variation;Genotype;germ free condition;HIV;HIV/AIDS;Human;Immune system;Macaca;Macaca mulatta;Modeling;Oregon;pandemic virus;pathogen;Pathogenesis;Primates;programs;Research;Research Subjects;Resources;simian human immunodeficiency virus;SIV;Target Populations;testing services;vaccine development;Vaccines;vector vaccine;Viral;Work

PROJECT_TITLE: SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J(51)]


PI_NAMEs: PRONGAY, KAMM  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;AIDS-Related Opportunistic Infections;animal breeding;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Artificial Insemination;Behavioral;Breeding;clinical care;Development;Disease;Disease Surveillance;enzootic;Evaluation;Female;fighting;Functional disorder;Genetic Variation;germ free condition;Goals;Grant;Health;Herpesvirus 1;HIV;HIV Infections;HIV vaccine;HIV/AIDS;Immune response;Infant;Infection;innovation;Macaca mulatta;Modeling;Monitor;Mycobacterium tuberculosis;nonhuman primate;Outcome;Pathogenesis;Persons;Pharmaceutical Preparations;Practice Management;preservation;Preventive care;programs;psychologic;Research;Resources;Risk;screening;Serology test;Simian Retroviruses;SIV;social;Target Populations;Vaccine Research;Vaccines;Virus;Weight maintenance regimen;Zoonoses

PROJECT_TITLE: Husbandry and Management Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  The overall goals of the proposed Career Development Award (K01) are to investigate the relationship between cognition and health promoting behaviors, clarify the moderating role of positive resources, and to determine the cumulative impact of these interactions on quality of life for older adults experiencing stress while living with HIV. Older adults living with HIV have greater risks for cognitive impairment which can negatively impact the ability to engage in behaviors that benefit health. A greater understanding of the factors that promote healthy behaviors despite cognitive impairment is needed in order to address the needs of the aging population of individuals living with HIV and the corresponding public health burden.

PI_NAMEs: NGUYEN, ANNIE LU (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adherence;Adult;Age;Aging;aging population;Alzheimer's Disease;antiretroviral therapy;Attention;Behavior;Behavioral;Biometry;Buffers;career;Caring;Characteristics;Chronic;Cognition;Cognitive;Cognitive deficits;cohort;Community Health;comorbidity;Consequences of HIV;Continuity of Patient Care;Data Analyses;Data Collection;Dementia;demographics;design;Development;Dimensions;disability;Disparity;experience;Exposure to;falls;Goals;Health;Health behavior;Health Benefit;Health Promotion;Health Resources;HIV;HIV anti-retroviral;HIV Infections;HIV-associated neurocognitive disorder;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;K-Series Research Career Programs;Leisure Activities;Life;Life Cycle Stages;Life Expectancy;life span;Life Stress;Memory;Mental Depression;Mental Health;multiple data sources;neurobehavioral;Neurologic;older adult;Older Population;Outcome;Participant;Perception;Persons;Physical activity;Play;Population;population health;programs;Psyche structure;psychosocial;Psychosocial Factor;psychosocial resources;Public Health;Quality of life;Research;Research Activity;Research Design;Research Personnel;research study;Resources;Risk;Role;social stigma;Social support;Stigmatization;Stress;stressor;substance use;therapy adherence;Time;Training;Vulnerable Populations

PROJECT_TITLE: Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Human cytomegalovirus (HCMV) causes significant disease in individuals with weakened immune systems. How HCMV can replicate so efficiently in the face of host induced strong antiviral responses is not fully known. In this proposed work we will extend our exciting findings where we have identified specific host directed modification of viral proteins that result in altered antiviral responses. Characterization of the biological mechanisms controlled by these host modifications will provide insight on inhibiting HCMV and potentially other viruses in general.

PI_NAMEs: MURPHY, EAIN A (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Anti-viral Response;arm;Biological;Biological Process;Biotin;Cells;Cysteine;cytokine;Cytokine Gene;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasm;Data;design;Disease;DNA;DNA Viruses;Equilibrium;Foundations;Genetic Transcription;Goals;Growth;Hematopoietic stem cells;Herpesviridae;Host Defense;Human;Immune response;Immune system;Immunocompetent;Individual;Infection;Innate Immune Response;insight;Integration Host Factors;Interferon Type I;Intervention;IRF3 gene;knowledge base;Laboratories;latent infection;Life Cycle Stages;Lytic;Lytic Phase;lytic replication;Macrophage;Mediating;Methodology;Modification;Morbidity - disease rate;mortality;Mutate;Mutation;new therapeutic target;Nitric Oxide;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;Play;Population;Post-Translational Protein Processing;Production;protein function;Protein S;Proteins;Proteomics;Regulation;Repression;Research;response;Role;Serine;Stimulator of Interferon Genes;Sulfhydryl Compounds;Symptoms;Testing;Therapeutic Intervention;Transcriptional Activation;Vaccines;Viral;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Antiviral responses of host mediated S-nitrosylation of viral proteins.

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


PI_NAMEs: DISSEN, GREGORY A (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS-Related Opportunistic Infections;Algorithms;Animal Model;Animals;Biological Assay;Biological Models;Breeding;Cost Savings;Derivation procedure;Development;Disease;Ensure;Enzyme-Linked Immunosorbent Assay;Funding;Genetic;germ free condition;Goals;Health;HIV;HIV/AIDS;improved;Individual;Macaca mulatta;Maintenance;Microarray Analysis;Monitor;next generation;nonhuman primate;Oregon;pathogen;Pathogenesis;pathogenic virus;Primates;Protein Microarray Assay;Protein Microchips;Regimen;Reproducibility;Research;Resources;screening;Sensitivity and Specificity;Serology test;Standardization;Testing;testing services;Time;United States National Institutes of Health;Vaccines;Validation;Viral Antibodies;Virus;virus testing;Zoonoses

PROJECT_TITLE: Viral Testing Core


PI_NAMEs: VINSON, AMANDA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Algorithms;Alleles;animal colony;Animal Husbandry;Animal Model;Animals;Biological Assay;Biomedical Research;Breeding;Caring;cost;cost effective;Data;Dedications;demographics;Development;Disease;Disease Progression;Ensure;experience;Gene Frequency;Genetic;genetic pedigree;genetic testing;Genetic Variation;genome-wide;Genomics;Genotype;Goals;Health;HIV;human disease;improved;Individual;innovation;interest;Knowledge;Lead;Macaca;Macaca mulatta;member;MHC Class I Genes;Morbidity - disease rate;mortality;nonhuman primate;novel;offspring;Periodicals;Phenotype;Population;Practice Management;preservation;Primates;Protocols documentation;Recommendation;Recording of previous events;recruit;Reporting;Research;Silver;SIV;success;Technology;Time;trait;United States;Work;working group

PROJECT_TITLE: MHC Genetic Typing Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Public statement. Chronic Hepatitis B Virus infection is a major factor for liver cancer development. There are no effective treatments to suppress chronic HBV infection. Our studies investigate a novel mechanism that silences transcription of viral and cellular genes linked to liver cancer.

PI_NAMEs: KAZEMIAN, MAJID  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Anabolism;Anti-viral Agents;Binding;Cancer cell line;Cell Nucleus;Chromatin;Chromatography;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;Complex;curative treatments;Data;Databases;Development;DNA;Down-Regulation;effective therapy;Epigenetic Process;epigenetic silencing;Etiology;Exhibits;EZH2 gene;Gene Expression;Gene Silencing;Genes;Genetic Transcription;HDAC1 gene;helicase;Hepatitis B Infection;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocarcinogenesis;Hepatocyte;Histone Deacetylase;Human;Immune signaling;Immunologic Surveillance;In Vitro;Individual;insight;Interferon alpha;Interferon Type II;Interferons;kinase inhibitor;knock-down;Label;Link;Malignant neoplasm of liver;Mediating;Methyltransferase;Modeling;novel;Nuclear;Nuclear Extract;nuclease;Oncogenes;Patients;Polycomb;Primary carcinoma of the liver cells;Prognosis;Proteins;Proteomics;Recombinants;Repression;response;RNA;RNA Helicase;Role;sensor;Signal Pathway;Signal Transduction;STAT1 gene;therapeutic target;transcription factor;transcriptome sequencing;Transferase;Translations;Viral;Virus;Virus Diseases;Virus Replication;WNT Signaling Pathway

PROJECT_TITLE: Role of DDX5 in Hepatitis B virus transcription and hepatocarcinogenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Disability Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: The proposed research is relevant to public health because developmental damage to the corticospinal tract in cerebral palsy and after neonatal spinal injuries represents a significant burden to their family as well as a major cost burden to the health care system. For successful diagnosis and treatments, a critical need is to have better approaches that can accurately predict long-term movement disability in babies born with brain damage, a presently unattained goal, in part because of a lack of good mouse models to investigate this problem. Our proposed research will identify early biomarkers to predict long-term disability in mouse models of corticospinal dysfunction that can eventually be applied toward diagnosing and predicting disability, as well as evaluating efficacy of treatments in humans with developmental brain damage.

PI_NAMEs: SAHNI, VIBHU VINODCHANDRA (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Affect;Anatomy;arm;Artificial Intelligence;Artificial Intelligence platform;Behavior;behavior test;Behavioral;Biological Markers;Brain Injuries;Cerebral Palsy;Child;Complex;Corticospinal Tracts;cost;Data;Development;Developmental Biology;Developmental Delay Disorders;Diagnosis;disability;early detection biomarkers;Early Diagnosis;Early identification;efficacy evaluation;Equilibrium;experimental study;Family;Functional disorder;functional improvement;Genetic;Goals;Healthcare Systems;Human;human subject;hypoxia neonatorum;Image;improved;infancy;Injury;Intervention;Investigation;Knockout Mice;Lesion;Life;Locomotion;Long term disability;loss of function;Machine Learning;Measures;Methodology;Microsurgery;millisecond;Motion;motion sensitivity;Motor;motor control;Motor Cortex;mouse model;Movement;Mus;Natural Language Processing;Neonatal;neonatal mice;neonate;nervous system development;Neural Pathways;novel;novel strategies;old mice;Outcome;Play;postnatal;postnatal development;pre-clinical;Pre-Clinical Model;Probability;Public Health;Publishing;Recovery of Function;repaired;Reproducibility;Research;Role;skills;Specificity;Spinal;Spinal Injuries;Stereotyping;Structure;Techniques;Testing;Therapeutic Intervention;Training;Treatment Efficacy;Videotape;Work

PROJECT_TITLE: Using Natural Mouse Movement to Establish a Developmental "Biomarker" for Corticospinal Damage

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Dopamine signaling is key to the rewarding effects of stimulant drugs, but much less is known about the involvement of other neurotransmitters and receptors in response to repeated drug exposure. Whole-brain multimodal imaging will be used to non-invasively measure the interaction between neurotransmitter systems, specifically neuroadaptations occurring at dopamine-glutamate targets. This study will reveal the importance of multi-receptor interactions and the potential role of glutamate and other targets in the treatment of drug addiction.

PI_NAMEs: SANDER, CHRISTIN Y. (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: addiction;addiction liability;Affect;Award;Brain;Brain imaging;connectome;Dopamine;Dopamine Receptor;Drug abuse;Drug Addiction;Drug Exposure;drug of abuse;drug reward;Ensure;experimental study;Functional Magnetic Resonance Imaging;Future;Glutamates;Image;imaging approach;insight;Knowledge;Measures;Methodology;Molecular;Multimodal Imaging;multimodality;neuroadaptation;neurochemistry;neuroimaging;Neuronal Plasticity;Neuropharmacology;neurotransmission;Neurotransmitters;new therapeutic target;nonhuman primate;novel;Pharmaceutical Preparations;pharmacologic;Positron-Emission Tomography;programs;receptor;response;reward processing;Rewards;Role;Sensory Receptors;Signal Transduction;Stimulant;stimulant exposure;System;Therapeutic Intervention;Time;tool;Work

PROJECT_TITLE: The neuropharmacology of brain activation during stages of drug abuse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The behavioral state of an animal – whether it is active, inactive, mating, or fighting – profoundly influences how it generates behavioral responses to environmental cues. However, because the environment is constantly changing, animals often switch behavioral states in a sensory-driven manner. To understand how sensory cues influence behavioral state generation and how the links between sensory cues and behavioral states can flexibly change, we will examine the flow of information from the sensory periphery to key neural populations that mediate behavioral state control in the well-defined nervous system of the nematode C. elegans.

PI_NAMEs: FLAVELL, STEVEN WILLEM (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Afferent Neurons;Animal Feed;Animals;Architecture;Behavior;Behavior Control;behavior influence;behavior prediction;behavior test;Behavioral;behavioral response;Brain;Caenorhabditis elegans;Calcium;Cells;Chemoreceptors;Complex;Coupling;Cues;Data;Desire for food;Detection;Environment;Exhibits;experience;Exposure to;feeding;fighting;flexibility;Food;Food deprivation (experimental);food environment;Generations;Genetic;genome-wide analysis;Image;Imaging Device;Ingestion;Intestines;Link;Locomotion;Logic;Mediating;Metabolic;Molecular;Movement;Nematoda;Nervous System;neural;neural circuit;Neural Pathways;neuromechanism;Neuromodulator;Neurons;Neurosciences;Odors;olfactory receptor;Partner in relationship;Pathway interactions;Physiological;Population;Population Control;Probability;receptor expression;response;Satiation;Sensory;Sensory Receptors;sensory system;Signal Transduction;Smell Perception;Source;Speed;Starvation;stressor;Synapses;System;tool;Work

PROJECT_TITLE: Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegans

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Estrogen;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE Many mental health disorders, such as autism, depression, anxiety, and schizophrenia, present with sex-biased ratios in incidence, severity, age-of-onset, or prognosis. The goal of this proposal is to understand how gonadal steroid hormones regulate sex differences in gene expression and neuronal connectivity. Understanding the distinct developmental trajectories of female and male brains will therefore advance our knowledge of the basic mechanisms underlying sex differences in psychiatric conditions.

PI_NAMEs: TOLLKUHN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acute;Adult;Adult women;Affect;Age of Onset;Anxiety;autism spectrum disorder;autosome;Behavior;behavioral response;Birth;Brain;Brain region;Candidate Disease Gene;Cell Survival;cell type;Cells;Chromatin;Cre driver;CRISPR/Cas technology;critical developmental period;critical period;Data;Development;Disease;Disease susceptibility;Enhancers;Epigenetic Process;epigenetic regulation;epigenomic profiling;ESR1 gene;Estradiol;Estrogens;Estrous Cycle;Estrus;Etiology;Event;Female;Funding;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomics;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Hormonal;hormonal signals;Hormone Receptor;Hormones;Incidence;Individual;insight;Instinct;Interneurons;Knowledge;Label;Life;loss of function;male;Maps;Masculine;Mediating;Mental Depression;Mental disorders;Mental Health;Modeling;Molecular;Morphology;Mus;Neonatal;neonate;neural;neural circuit;Neurons;neurophysiology;novel;novel strategies;Nuclear Receptors;Perinatal;Periodicity;Phenotype;Ploidies;Population;postnatal;postnatal development;Progesterone;Progesterone Receptors;Prognosis;programs;public health relevance;recruit;Regulatory Element;Research;resilience;Resolution;response;Role;Schizophrenia;Severities;sex;Sex Bias;Sex Chromosomes;Sex Differences;Sex Differentiation;sex variable;sexual dimorphism;Signal Transduction;social;Social Behavior;Specific qualifier value;Stimulus;Structure;Structure of terminal stria nuclei of preoptic region;success;System;Techniques;Testing;Testosterone;Time;Tissue-Specific Gene Expression;Untranslated RNA;Variant;Vertebrates;Viral;women versus men;Work

PROJECT_TITLE: Epigenetic Regulation of Sex Differences in the Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE We have recently identified a new clinical candidate for the potential treatment of Chagas disease, a result of infection of humans and other mammals by the parasite, Trypanosoma cruzi. The work proposed in this application will investigate the uptake and metabolism of this drug by T. cruzi. These studies are expected to provide new insights into the mechanisms of drug action and the potential for failure of this promising treatment.

PI_NAMEs: TARLETON, RICK L (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Affect;Americas;Carboxylic Acids;cell type;Cells;cellular targeting;Chagas Disease;Chronic;Cleavage And Polyadenylation Specificity Factor;clinical candidate;clinical development;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Development;drug action;drug metabolism;Drug resistance;Exhibits;extracellular;Failure;Fluorescence;Fluorogenic Substrate;fluorophore;Gene Family;Growth;Heart Diseases;Human;human migration;improved;In Vitro;Individual;Infection;Insecta;insight;Kinetics;Knock-out;Life;Life Cycle Stages;Light;Liquid Chromatography;Mammals;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic;Metabolism;Modeling;Monitor;nonhuman primate;Outcome;Parasites;Parasitic infection;Pathway interactions;Pharmaceutical Preparations;Population;Predisposition;Process;Prodrugs;Protozoa;Resistance;Resistance development;Risk;Risk Assessment;Safety;Serine carboxypeptidase;side effect;Sterility;System;tandem mass spectrometry;Testing;Therapeutic;Time;Treatment Failure;Trypanocidal Agents;Trypanosoma cruzi;uptake;Work

PROJECT_TITLE: The activation of benzoxaborole prodrug AN15368, a clinical candidate for Chagas disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Behavioral profiling of zebrafish larvae under the influence of neuroactives is at the vanguard of in vivo neuropharmacology, which has historically been dominated by costly and challenging experiments in rodents and primates. I co-developed a state-of-the-art platform in which drug-induced behaviors of hundreds of thousands of animals can be assessed, cataloged, and compared rapidly and on a scale that far exceeds historical precedents; I have coupled this technology with the recent advances in whole brain imaging to make observations that saliently connect chemistry, neuroanatomy, and behavior. This proposal is focused on new projects directed towards the discovery of substance use disorder pharmacotherapies, including alternatives to addictive opioids for pain management, acute reversal agent interventions, and attenuators of drug self- administration.

PI_NAMEs: MCCARROLL, MATTHEW N (contact)

PROJECT_TERMS: Acceleration;Acute;addiction;Addictive Behavior;Address;Affect;Alcohols;Analgesics;Anesthetics;Animal Model;Animals;Antidotes;Behavior;Behavioral;Behavioral Assay;Benzodiazepines;Biochemical;Biological Assay;Brain imaging;Cells;Central Nervous System;Cessation of life;Chemicals;Chemistry;Cocaine;cost;Coupled;Development;dizocilpine;drug induced behavior;drug of abuse;experimental study;Hand;high throughput screening;Image;in vivo;interest;Intervention;Ketamine;Larva;Lead;Life;Methamphetamine;Modeling;Modification;Morphine;Neuroanatomy;Neuropharmacology;new technology;Nicotine;novel;novel therapeutics;Opiate Addiction;Opioid;opioid overdose;Overdose;Pain management;pain model;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phenocopy;Primates;Rodent;Rodent Model;Sedation procedure;Self Administration;small molecule;Substance Use Disorder;Technology;technology platform;Therapeutic;Toxic effect;Translations;Work;Zebrafish

PROJECT_TITLE: New Technologies for Accelerating the Discovery and Characterization of Neuroactives that Address Substance Use Disorders


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

PHR: The proposed research seeks to understand how genetic and biophysical features of influenza viruses contribute to the spread of virions within infected hosts. Viral spread is central to the medical outcomes of influenza virus infection. It is expected that by understanding how this process works, how it differs between genetically-distinct viruses, and how it impacts the progression of infection, it will become possible to identify new strategies for preventing and controlling influenza.

PI_NAMEs: VAHEY, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Address;Affect;Anti-viral Response;Area;Binding Proteins;Biology;Biophysical Process;biophysical properties;Biophysics;Cells;Cellular Tropism;Cilia;co-infection;Data;Defect;Disease Progression;Disparate;Environment;Enzymes;Equilibrium;experimental study;flu transmission;Frequencies;Genes;Genetic;Genome;Goals;Growth;high resolution imaging;Human;Image;improved;Infection;Influenza;influenza infection;influenzavirus;insight;Integration Host Factors;Interferons;Intrinsic factor;Knowledge;Link;Mediating;Medical;Membrane Proteins;Methodology;Methods;Molecular;Movement;Mucins;Mucociliary Clearance;Mucous Membrane;Mutation;National Institute of Allergy and Infectious Disease;Neuraminidase;Outcome;outcome disparities;particle;Pattern;Phenotype;Play;prevent;Process;Proteins;receptor;receptor binding;Research;Resolution;response;Role;secondary infection;Shapes;Sialic Acids;Site;Strategic Planning;Structural Protein;Structure;Surface;Testing;tool;trait;universal influenza vaccine;Variant;Viral;Viral Load result;Viral Proteins;Virion;Virus;Virus Diseases;virus morphology;Virus Receptors;Virus Replication;Work

PROJECT_TITLE: Genetic and biophysical mechanisms that control influenza virus cellular multiplicity of infection


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The innate immune response is one of our most important defenses against viral infection, but we don’t know much about the specific innate effectors that play a role in whether a persistent HIV infection is established. We propose to define these key factors, taking a combined approach of studying this in humans and in biologically relevant cell culture systems using state-of-the-art functional approaches.

PI_NAMEs: OVERBAUGH, JULIE M. (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acute;acute infection;Address;Anti-viral Response;Area;arms race;biological systems;Biology;CD4 Positive T Lymphocytes;Cell Culture System;Cell Culture Techniques;Cell Line;cell transformation;cell type;Cells;Chronic;cohort;Cohort Studies;CRISPR library;CRISPR screen;CRISPR/Cas technology;Data;Data Collection;Effector Cell;Event;experience;experimental study;exposed human population;Exposure to;Gene Silencing;Genes;Goals;high risk;High Risk Woman;HIV;HIV Infections;Human;Immunologic Factors;In Vitro;in vivo;Individual;Infection;Innate Immune Response;innovation;insight;interest;Interferons;Knowledge;Measures;Methods;Modeling;Natural Immunity;Natural Killer Cells;novel;Outcome;Pathogenesis;Peripheral Blood Mononuclear Cell;Physiological;Play;Predisposition;pressure;Primary Cell Cultures;Property;prospective;Reporting;Research;response;Risk;Role;sample archive;sample collection;Sampling;sex;Shapes;simian human immunodeficiency virus;success;System;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;Technology;Testing;transcriptome sequencing;Transfection;transmission process;Up-Regulation;Variant;Viral;viral transmission;Virus;Virus Diseases;Woman;Work

PROJECT_TITLE: Early and Reinfection in High Risk Women


NIH_SPENDING_CATS: Clinical Research;Hematology;Immunotherapy;Infant Mortality;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Preterm infants “born too soon” are at increased risk of infections and sepsis with significant mortality and life- long complications. These studies will test two hypotheses that (1) the increased risk of infections and sepsis in premature neonates is due to abnormal myelopoiesis leading to increased immunosuppressive myeloid-derived suppressor cells (MDSCs) and innate immune effector cells, and (2) prophylactic treatment with immunomodulatory agents can induce ‘trained immunity’ by correcting the phenotype of both MDSCs and PMNs in premature neonates.

PI_NAMEs: LARSON, SHAWN DAVID (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adjuvant;Adult;Agonist;Anti-Bacterial Agents;Attenuated Vaccines;Birth;Cause of Death;Cell Count;Cell Maturation;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;clinically relevant;Cytometry;deviant;Effector Cell;Environment;Exhibits;fetal;Flow Cytometry;Functional disorder;Genomics;Gestational Age;high risk;Hospitalization;Human;human old age (65+);Immune;immune function;immune modulating agents;Immune response;Immunity;Immunologic Adjuvants;immunomodulatory strategy;immunoregulation;Immunosuppression;improved;in vivo;Incidence;Infant;Infant Mortality;Infection;infection risk;Inflammation;innate immune function;insight;Intra-abdominal;ITGAM gene;Knowledge;Life;Measles;microbial;microbial colonization;Modeling;Molecular;monocyte;mortality;mortality risk;multiple omics;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Natural Immunity;Neonatal;neonatal immune system;neonatal mice;neonatal sepsis;neonate;neutrophil;Newborn Infant;novel;organ injury;Outcome;pathogen;pathogen exposure;Phenotype;polymicrobial sepsis;Population;postnatal;Predisposition;premature;Premature Birth;Premature Infant;prenatal exposure;preterm newborn;prevent;Prevention;prophylactic;Prophylactic treatment;protective effect;Proteins;response;Risk;Role;SARS-CoV-2 infection;Sepsis;septic;Severities;Signal Pathway;single-cell RNA sequencing;Sterility;subcutaneous;Systemic infection;Technology;Term Birth;Testing;therapeutic target;Tissues;TLR4 gene;Training;Transgenic Organisms;Viral;Vulnerable Populations;Work

PROJECT_TITLE: Prevention of Neonatal Sepsis by Therapeutic Targeting of MDSCs

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: NORFOLK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PHR: PROJECT NARRATIVE In this application, I propose a set of genetic, biochemical and bioinformatics studies to understand: 1) the role of ADAR1 RNA editing in regulation of the maternal transcriptome in the oocyte and early embryo in young and old mice, and 2) the effect of ADAR1 RNA editing on RNA stability in oocytes and eggs from young and old mice. These mechanistic studies will advance our basic understanding of how post-transcriptional RNA processing is integral to the oocyte RNA environment, and hence, oocyte quality. The knowledge gained from this proposal could promote a shift in current paradigms and redirect research to accelerate progress in understanding infertility and disease.

PI_NAMEs: BRACHOVA, PAVLA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adenosine;adenosine deaminase;age related;age related decline;aging population;Area;Biochemical;Bioinformatics;blastocyst;Cells;Code;Codon Nucleotides;Competence;Congenital Abnormality;Coupled;Data;Deamination;decapping enzyme;Defect;Development;Disease;dosage;Double-Stranded RNA;dsRNA adenosine deaminase;egg;Embryo;Embryonic Development;Environment;Enzymes;experimental study;Female;female fertility;Fertility;Fluorescent in Situ Hybridization;Genetic;Genetic Transcription;Goals;Growth;Human;human embryonic development;Infertility;innovation;Inosine;Knock-out;Knowledge;male;Maternal Age;Maternal Messenger RNA;Mediating;Meiosis;Mentors;Mentorship;Messenger RNA;Modeling;Modification;Morula;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;Mus;mutant;novel;old mice;oocyte quality;Oocytes;Oogenesis;Partner in relationship;Pattern;Phase;Poly(A) Tail;Polyribosomes;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Process;Proteins;recruit;Regulation;Reproduction;reproductive;Research;RNA;RNA Editing;RNA Stability;Role;Scientist;spleen exonuclease;Spontaneous abortion;Testing;Training;Transcript;transcriptome;transcriptomics;Translations;Work;zona pellucida glycoprotein

PROJECT_TITLE: A-to-I RNA modifications in mouse oocytes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS