NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative The DNA damage response pathway is important for repair damage DNA in cells. Many cancer therapies involve DNA damage-inducing agent, and a detailed understanding of the DNA damage response pathway and in cancer cells will help us to design targeted therapy for specific cancers. Ovarian cancer (OC) is one of the most common gynecological cancers among women worldwide. We recently identified SYK tyrosine kinase as a key player in the DNA damage response and contributes to chemoresistance in ovarian cancer. We will study how SYK regulates DNA repair and whether we can use SYK inhibitor to sensitize ovarian cancer cells to chemotherapy and PARP inhibitor.

PI_NAMEs: LOU, ZHENKUN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affect;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;cancer therapy;Carboplatin;Cells;Chemoresistance;chemotherapy;Cisplatin;Clinic;Clinical Research;design;Development;Disease;DNA Damage;DNA lesion;DNA Repair;efficacy evaluation;Genes;Germ Lines;high risk;homologous recombination;immunoregulation;in vivo;inhibitor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;mouse model;Mutate;new therapeutic target;novel;Organoids;Outcome;overexpression;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Protein Tyrosine Kinase;Proteins;Radiation;recruit;Recurrence;Regulation;Resistance;response;Role;Serous;Signal Transduction;Site;SYK gene;targeted treatment;Testing;therapeutic biomarker;therapeutic target;Woman;Xenograft procedure

PROJECT_TITLE: Sensitizing Ovarian Cancer To PARP inhibitor and platinum treatment


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: La Jolla

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Most genetic variants associated with common diseases are difficult to interpret, because they lie within non- coding regions of the genome with unknown function. This project will leverage high-throughput genomic perturbations and computational analyses to establish a new strategy to discover novel regulatory sequences, interpret non-coding variants, and connect disease-associated variants to the genes they regulate. The results from this project will accelerate understanding of gene regulation and molecular mechanisms underlying human diseases.

PI_NAMEs: MCVICKER, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Alleles;Autoimmune;Biology;Cardiovascular system;Catalogs;Cell Proliferation;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Analysis;CRISPR interference;Data;Differentiated Gene;Disease;Enhancers;experimental study;Gene Expression;Gene Expression Regulation;Genes;genetic variant;Genetic Variation;Genome;genome editing;Genome Mappings;genome wide association study;Genomic Segment;Genomics;Goals;human disease;Human Genetics;Immune;Measures;Metabolic;Molecular;novel;Outcome;Research;single-cell RNA sequencing;T cell differentiation;T-Lymphocyte;trait;Untranslated RNA;Variant

PROJECT_TITLE: Using genomic perturbations to understand trait-associated human genetic variation


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: Roanoke

ORG_NAME: BEAM DIAGNOSTICS, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE Fatal opioid overdose is one of the most pressing issues affecting the U.S., yet the current standardized screening measures for opioid misuse in clinical practice are under-performed, laborious, and susceptible to demand characteristics and concerns about stigmatizing the patient. To combat these issues, BEAM Diagnostics, Inc. developed Beacon-OUD, a digital opioid misuse assessment that efficiently produces an objective measure and prevents potential judgements related to patient status, circumstance, or bias. This proposal, an extension of a successful Phase I STTR, seeks to develop Beacon-OUD into a fully-realized product for use both as a stand-alone tool and as an EMR-integrated solution for large healthcare systems to maximize standardized opioid screening in a variety of healthcare settings.

PI_NAMEs: SNIDER, SARAH EMILY (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: acceptability and feasibility;Addictive Behavior;Address;Adopted;Adoption;Affect;American;Assessment tool;Behavior Disorders;Behavioral;behavioral economics;Behavioral Sciences;Caring;Cessation of life;Characteristics;Clinical;Clinical assessments;clinical development;clinical practice;Clinical Research;combat;commercialization;Communication;Computerized Medical Record;COVID-19 pandemic;Death Rate;Decision Making;Development;Diagnostic;digital;digital assessment;digital platform;digital tool;disability;discounting;disorder risk;Education;Educational Materials;electronic medical record system;evidence base;experience;Family health status;Family Practice;Feedback;Future;Goals;health care disparity;health care settings;Health Insurance Portability and Accountability Act;Health Personnel;Health system;Healthcare;Healthcare Systems;Impairment;improved;improved outcome;Individual;insight;instrument;interoperability;Interview;Judgment;Language;Limited English Proficiency;Literature;Marketing;Measurement;Measures;Medical;medical specialties;Mental Health;Methodology;Modeling;Morbidity - disease rate;mortality;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Outpatients;Output;Pathology;patient health information;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Play;point of care;Positioning Attribute;Predisposition;prevent;Primary Care;primary care provider;Process;Prognosis;prototype;Provider;provider-level barriers;Psychological reinforcement;Recommendation;reinforcer;relapse prediction;relapse risk;Reporting;Rewards;Risk Assessment;Role;routine practice;Science;screening;Screening procedure;Secure;Security;Self Administration;Severities;Site;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Spanish;Standardization;Stigmatization;Structure;Substance Use Disorder;Tablets;Technology Transfer;Testing;Time;tool;Translating;Translations;United States;uptake;usability;Visit

PROJECT_TITLE: Beacon-OUD: Behavioral Economic Screening Tool of Opioid Use Disorder for Use in Clinical Practice


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Skin Cancer

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The ability to detect low levels of cancer is crucial for cancer diagnosis and treatment; however, even state-of- the-art techniques such as imaging and ‘liquid biopsy’ through deep sequencing fail to detect cancer when the tumor burden is extremely low, as can occur after treatment or surgery when small numbers of cancer cells remain. To address the challenges of detecting such low levels of cancer we propose to make non-incremental advances in our promising recently developed technology – MRDetect – which uses a sample of the patient's blood to find low levels of tumor by employing powerful computational tools of artificial intelligence to dramatically boost cancer detection. We expect that these advances will also foster broad adoption of this new technology across cancer, empowering precision cancer treatment.

PI_NAMEs: LANDAU, DAN  (contact);ROBINE, NICOLAS

PROGRAM_OFFICER_NAME: BYUN, JUNG SHIN

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adoption;advanced disease;Aftercare;Artificial Intelligence;Biological Markers;Blood;burden of illness;Cancer Burden;cancer cell;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Patient;cancer recurrence;cancer therapy;cell free DNA;Cells;checkpoint inhibition;Clinical;clinical application;clinical care;Colorectal Cancer;computer scientist;computerized tools;Copy Number Polymorphism;Custom;Data;de novo mutation;deep learning;deep sequencing;denoising;Detection;Detection of Minimal Residual Disease;detection platform;detection sensitivity;Development;Disease;DNA;empowerment;Engineering;Ensure;Epigenetic Process;Excision;Face;FDA approved;Fostering;Genes;Genome;genome sequencing;genome-wide;Genomics;high risk;Image;Immunotherapy;improved;In complete remission;Interdisciplinary Study;Joints;Left;Link;liquid biopsy;Machine Learning;machine learning framework;Malignant Neoplasms;Measures;Medicine;Melanoma;Methods;Monitor;mortality;multidisciplinary;Mutation;Nature;Neoadjuvant Therapy;new technology;Noise;Non-Invasive Detection;non-invasive monitor;Non-Small-Cell Lung Carcinoma;Oncologist;Oncology;Operative Surgical Procedures;Pathologic;Patients;Performance;personalized immunotherapy;Plasma;Postoperative Period;Precision cancer therapy;Prediction of Response to Therapy;prognostic;Proliferating;Recurrent disease;relapse risk;Residual Neoplasm;response;Sampling;Signal Transduction;Single Nucleotide Polymorphism;Site;Solid Neoplasm;Syncope;targeted sequencing;Techniques;Technology;Testing;Tissues;tumor;Tumor Burden;tumor DNA;Tumor stage;Tumor Tissue;variant detection;whole genome

PROJECT_TITLE: Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Obesity

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: RELEVANCE TO PUBLIC HEALTH Human physiology is markedly influenced by environment through interaction with a family of sensors known as PAS proteins. Proteins such as the Ah receptor influence our response to the microbiome, proteins like Clock influence our response to light and circadian time and the HIFs influence our response to atmospheric oxygen levels. By understanding how these proteins effect human physiology we can better understand and design prevention strategies and therapeutics for a variety of environmentally modified diseases such as cancer, diabetes, inflammatory bowel disease, and obesity.

PI_NAMEs: BRADFIELD, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Aryl Hydrocarbon Receptor;Atmosphere;Behavior;Biochemical;Chemical Exposure;circadian;cofactor;design;Diabetes Mellitus;Disease;Environment;experience;Family;Freedom;Genes;Genetic;Health;Human;human morbidity;Infertility;Inflammatory Bowel Diseases;insight;Intervention;Ligands;Light;Malignant Neoplasms;microbiome;Obesity;Oxygen;Pathway interactions;Physiology;Play;Population;Prevention strategy;programs;Protein Family;Proteins;Public Health;Reagent;Research Project Grants;response;Role;Scientist;sensor;Signal Transduction;Therapeutic;Time;Vision

PROJECT_TITLE: The PAS Sensor Family and Human Health


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The Pharmacology and Molecular Sciences (PMS) Training Program at The Johns Hopkins University School of Medicine provides trainees with state-of-the-art research knowledge and skills that prepare them to lead successful, rewarding careers impacting diverse areas of pharmacology toward: new target discovery and drug development, understanding drug mechanisms and delivery, and influencing drug policy and regulation.

PI_NAMEs: FREEL MEYERS, CAREN L. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Pharmacology and Molecular Sciences Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Congenital heart disease (CHD) is the leading cause of death due to birth defects, but the etiologies remain mostly unknown. We have identified a gene named SHROOM3 as a candidate for causing CHD, and this project investigates SHROOM3’s mechanism in Wnt/PCP signaling in the heart. Identifying a novel CHD candidate, and its mechanism of action, has potential to improve CHD diagnosis, identify comorbidity risks, tailor treatment strategies, and develop therapies.

PI_NAMEs: DURBIN, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Actomyosin;Antibodies;Apical;Automobile Driving;Award;Binding;Biological Assay;Body System;Candidate Disease Gene;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cause of Death;Cell Line;cell motility;Cell Polarity;Characteristics;Cleft Palate;Co-Immunoprecipitations;comorbidity;Congenital Abnormality;congenital heart abnormality;constriction;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Development;Developmental Biology;Disease;disease model;disease phenotype;Down-Regulation;Embryo;Environment;Etiology;Exhibits;exome sequencing;Extramural Activities;Frequencies;Funding;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genome editing;Genomics;Goals;Grant;Heart;heart defect;Heart Diseases;heart disorder diagnosis;Heterozygote;Human;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Vitro;in vivo;Indiana;Individual;individualized medicine;induced pluripotent stem cell;Kidney;Lead;Left;Link;loss of function;MAPK8 gene;Mentors;migration;Molecular Biology;Movement;Mus;Names;Neural Crest;Neural Crest Cell;Neural tube;novel;Pathogenesis;Pathway interactions;Patients;Pattern;pediatric department;Phenocopy;Phenotype;Phosphorylation;Physicians;planar cell polarity;Prognosis;rare variant;Research;Research Personnel;Rho-associated kinase;Risk;Scientist;Shapes;Signal Pathway;Signal Transduction;skills;statistics;supportive environment;targeted treatment;Testing;therapy development;Time;TNFSF5 gene;transcriptome sequencing;translational research program;treatment strategy;United States National Institutes of Health;Universities;Variant;Western Blotting;WNT Signaling Pathway;Writing

PROJECT_TITLE: "SHROOM3 is a Novel Cause of Congenital Heart Disease"

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Program narrative The Training Program in Pharmacological Sciences provides PhD students with a comprehensive background in the discipline of Pharmacology by bringing together training faculty from different research fields involved in the discovery, development and use of therapeutic compounds, exposing students to relevant clinical problems, emphasizing translational research, and providing opportunities for students to present their research in national and international meetings. The program offers courses in Pharmacology, provides training in quantitative research skills, scientific communication and writing, and supports career development activities to ensure the success of students in subsequent research-intensive and research-related careers. The training grant supports students early during their training (1st and 2nd year), emphasizes recruitment and retention of diverse students, upholds a culture of responsible conduct in research as well as rigor and reproducibility in scientific research and has outstanding outcomes, with alumni represented in the entire spectrum of the research enterprise, leading research groups in academia and industry, defining patent law, and shaping future research policy.

PI_NAMEs: COLOGNATO, HOLLY A (contact)

PROJECT_TERMS: pharmacologic;Science;Training Programs

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over half of all low-income, U.S. children live in unaffordable, unstable, and/or substandard-quality housing, which has been linked to a range of adverse child outcomes; however, little is known about the impact of these housing conditions on infants’ and toddlers’ health and development, how housing and neighborhood environments interact to influence young children’s healthy development, and whether other anti-poverty programs can improve housing circumstances for low-income families with young children. Using data from the NICHD-funded (R01HD087384) Baby’s First Years (BFY) study – a large-scale randomized control trial evaluating the impact of a monthly, unconditional cash transfer (UCT) to low-income mothers – I will study how a UCT impacts housing affordability, composition (i.e., who lives in the household), stability, and quality among low-income families with infants and toddlers, the configurations of housing and neighborhood ecosystems experienced by low-income families, and how housing and neighborhood characteristics impact young children’s healthy development. Results from this proposal will offer new insights into how early childhood housing and neighborhood conditions interact with family economic resources to shape children’s health and development trajectories, as well as inform the design of anti-poverty programs aimed at improving early childhood environments.

PI_NAMEs: STILWELL, LAURA ROSE (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adult;Age;age group;Area;Asthma;Behavioral;behavioral health;Brain;Caring;Characteristics;Child;Child Development;Child Health;Child Welfare;Childhood;Clinical;Code;Cognitive;Control Groups;cost;Crime;Crowding;Data;Data Sources;Dedications;design;Development;Dimensions;early childhood;Economics;Ecosystem;Education;Eligibility Determination;Emotional;Ensure;Environment;experience;Face;Family;Family Process;Fellowship;Funding;Goals;Grouping;Health;Home;Household;Housing;improved;Income;Infant;Injury;insight;Knowledge;Language Development;Linear Regressions;Link;Low income;lower income families;Measures;Mediating;Mediation;Medical;Mental Health;Mentorship;Methods;Modeling;Mothers;National Institute of Child Health and Human Development;Neighborhoods;nutrition;Outcome;Parents;Participant;physical conditioning;Physicians;Policies;Pollution;Positioning Attribute;Poverty;poverty reduction;programs;Property;public health research;Qualifying;Randomized, Controlled Trials;Reporting;Research;Resources;Risk;Role;Sampling;Scientist;Shapes;skills;Statistical Methods;success;Surveys;Taxes;Time;Toddler;Training;Work

PROJECT_TITLE: The Causal Impact of Poverty Reduction on Housing Conditions of Low-Income, U.S. Children and the Role of Housing and Neighborhood Ecosystems on Young Children's Healthy Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The issue of chromosome interactions is clearly relevant to public health, as these can lead to dramatic changes in transcription and may, therefore, directly contribute to disease. Indeed, aberrant interactions may also increase mitotic recombination, aneuploidy, and the formation of translocations, all of which have long been known to be underlying causes for many diseases, including cancer. As the mechanisms of chromosome interactions have not yet been systematically explored, this study has the potential to reveal new therapeutic targets for the treatment and prevention of chromatin-based diseases.

PI_NAMEs: JOYCE, ERIC F. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Aneuploidy;Architecture;Biological Assay;candidate identification;Cell Nucleus;Cells;Chromatin;Chromatin Loop;Chromosome Positioning;Chromosomes;Complex;Development;Disease;DNA;Enhancers;Fluorescent in Situ Hybridization;gene function;Genes;genetic information;Genetic Transcription;Genome;Genomics;Goals;In Situ;Inherited;Malignant Neoplasms;Methods;Mitotic Recombination;Molecular;new therapeutic target;novel;Nuclear;Positioning Attribute;Prevention;Proteins;Public Health;Regulation;Resolution;Technology;three dimensional structure;Time;tool;Work

PROJECT_TITLE: Regulation of chromatin folding in space and time

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Genetics;Nutrition;Urologic Diseases

ORG_CITY: AKURE

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: THE FEDERAL UNIVERSITY OF TECHNOLOGY, AKURE, NIGERIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates a new and alternative strategy to understanding the potential mechanistic link between diet and bladder dysfunction through epigenetic modifications in LUTD, an understudied disorder with high prevalence in African countries, opening up new directions for possible public health impact and other management strategies. Thus, the proposed research is relevant to the NIH’s mission to “foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health”.

PI_NAMEs: ADEDEJI, TEMITOPE GABRIEL (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Affect;African;Anatomy;Award;Benign Prostatic Hypertrophy;Bladder;Bladder Diseases;Bladder Dysfunction;Bladder Tissue;Calcium Signaling;Carbohydrates;career;cell behavior;Cell Physiology;Cells;Characteristics;Clinical;Consumption;Country;Creativeness;Data;Data Analyses;Diet;dietary;Disease;DNA biosynthesis;Educational Status;Environmental Risk Factor;Eosine Yellowish;Epigenetic Process;Fatty acid glycerol esters;feeding;Female;Fostering;Foundations;Functional disorder;Gene Expression;Genetic Transcription;Global Change;Goals;Health;health management;High Fat Diet;High Prevalence;Histology;histone modification;Histones;Hyperplasia;Hypertrophy;Immunohistochemistry;improved;Incidence;Individual;innovation;insight;Intervention;Kidney;Knowledge;Life Style;lifestyle factors;Link;Low Prevalence;Lower urinary tract;lower urinary tract symptoms;Macronutrients Nutrition;male;Mission;Modeling;Modification;Molecular;Molecular Biology Techniques;Morphology;Nutrient availability;Nutritional;Obesity;Obstruction;Outcome;Pathology;Patients;Phenotype;Physiology;Play;Population;Positioning Attribute;Post-Translational Protein Processing;Prevalence;Prognosis;Proteins;Proteomics;Public Health;Rattus;Reporting;Research;Research Personnel;response;Role;Scientific Advances and Accomplishments;Scientist;Signal Transduction;Stains;Symptoms;Techniques;Testing;Time;Training;Transcriptional Activation;transcriptome;transcriptome sequencing;United States National Institutes of Health;Urinary Incontinence;Urinary tract;Urinary Tract Physiology;Urologic Diseases;Urothelium;Weight;Western Blotting;Wistar Rats

PROJECT_TITLE: Epigenetic Influence of Diet on Bladder Physiology

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSURGERY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Utilizing complementary gain-of-function and loss-of-function approaches, the proposed studies will test the efficacy and safety of targeting miR-30c as novel stroke therapeutics in aged mice. Furthermore, we will identify the molecular mechanisms of action of targeting miR30c against cerebral ischemia/reperfusion injury. The long- term goal of these studies is to evaluate if targeting miR-30c is a viable option for stroke therapy in older population at high risk for stroke.

PI_NAMEs: LI, GUOHONG  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3' Untranslated Regions;Acute;acute stroke;age related;age related decline;aged;Animal Model;animal mortality;Atherosclerosis;Attenuated;Binding;Binding Sites;Blood;Blood Platelets;Brain;Brain Edema;Brain Infarction;Brain Injuries;Brain Ischemia;CASP3 gene;Caspase;Cerebral Ischemia;cerebral microvasculature;combat;Complications of Diabetes Mellitus;design;Deterioration;Development;Dose;effective intervention;efficacy evaluation;efficacy testing;EIF-2alpha;endoplasmic reticulum stress;experimental study;Female;gain of function;Genes;Goals;Guidelines;Hemorrhage;high risk;Hippocampus;Hour;Hyperglycemia;Hyperlipidemia;Immunosuppression;in vivo;Individual;Industry;Infection;Inflammatory Response;Injury;innovation;Intravenous;intravenous injection;Ischemia;Ischemic Stroke;Life;loss of function;male;Mediating;MicroRNAs;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Target;Mus;Nervous System Disorder;Neurologic;Neurologic Deficit;neuron apoptosis;neuron loss;Neuronal Injury;Neurons;novel;novel therapeutic intervention;old mice;Older Population;Oligonucleotides;Pathologic;Pathologic Processes;Patients;Plasminogen Activator Inhibitor 1;post stroke;pre-clinical;prevent;Recovery of Function;Regulation;Reperfusion Injury;Reperfusion Therapy;response;Role;Safety;Secondary to;Stroke;stroke risk;stroke therapy;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic miRNA;thromboinflammation;thrombolysis;thrombotic;Time;treatment and outcome;Update;young adult

PROJECT_TITLE: Novel Targets and Therapeutic Interventions against Cerebral Ischemia-Reperfusion Injury

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Mental Health;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed research is relevant to public health because it represents a novel exploration of gait quality impairments in a chronic low back pain population with heightened fear-avoidance/pain catastrophizing, which puts them at increased risk for poor clinical outcomes. Identification of gait quality impairments in this high-risk population may lead to improved physical therapy interventions. Thus, the proposed research is relevant to the NIH’s mission to enhance health and reduce illness and disability.

PI_NAMEs: BAILES, ANNA H (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accelerometer;Address;Adoption;Adult;Anxiety;Attention;Back;Behavior;Belief;Biomedical Engineering;Biometry;Black race;career;Chronic low back pain;chronic pain management;Clinical;clinical predictive model;clinical training;Cognition;Cognitive;cognitive change;cognitive function;Country;Data Set;design;Development;disability;disability risk;Doctor of Philosophy;Evaluation;experience;Failure;Fellowship;Fright;functional decline;Funding;Gait;gait symmetry;Goals;Grant;Health;Helping to End Addiction Long-term;high risk population;Human;Impairment;improved;improved outcome;Individual;Infrastructure;Intervention;Knowledge;Literature;Low Back Pain;Measures;Mentorship;Mission;Mobility decline;Movement;Musculoskeletal Equilibrium;novel;Outcome;Pain;pain catastrophizing;Participant;Patients;Pattern;Persistent pain;Physical therapy;Population;Populations at Risk;programs;Psychological Factors;Psychology;Public Health;Questionnaires;recruit;Research;Research Methodology;Research Training;Risk;Role;Sample Size;Sampling;Scientist;Solid;System;Testing;Therapeutic Intervention;Thinking;Training;Translational Research;Treatment outcome;United States National Institutes of Health;Universities;Vulnerable Populations;Walking;Work

PROJECT_TITLE: Relationships Between Pain-Related Psychological Factors, Gait Quality, and Attention in Chronic Low Back Pain


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: PISCATAWAY

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: A next-generation extendable simulation environment for affordable, accurate, and  efficient free energy simulations PI: Tai-Sung Lee, Rutgers University, Piscataway, NJ 08854-8087 USA. In the filed of molecular simulations, a new generation of integrated methods, workflows, and phys-ical models are emerging, which leads to a critical barrier to progress in the field is the lack of a software package with seamless incorporation of existing software modules with emerging scien-tific advances. To surmount this barrier and in responding to NIH Focused Technology Funding Opportunity which calls for innovative, focused technology development of a working prototype of critical research tools, we propose to develop a next-generation executing environment for sim-ulations. The proposed work will offer fast prototyping, accessibility to new algorithms, further improvements in single-GPU performance, strong scaling in synchronous and asynchronous en-semble methods, and interoperability with different types of force fields and physical models.

PI_NAMEs: LEE, TAI-SUNG  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affinity;Algorithms;Binding Proteins;Biocompatible Materials;Chemical Models;Code;Computer software;Coupling;Cryoelectron Microscopy;Data;data structure;design;Devices;drug discovery;Engineering;Environment;Foundations;Free Energy;Funding Opportunities;Future;Generations;Goals;Graph;Growth;High Performance Computing;Hybrids;improved;Individual;Industrialization;innovation;Internet;interoperability;Language;Learning Module;Libraries;Link;Machine Learning;Maps;Memory;Methods;model building;Modeling;Modernization;Molecular;molecular dynamics;molecular scale;Names;Network-based;neural network;next generation;novel;Nucleic Acids;particle;Performance;physical model;Process;programs;Proteins;Protocols documentation;prototype;Pythons;Quantum Mechanics;Research;Resources;Running;Sampling;Science;Scientific Advances and Accomplishments;Services;simulation;simulation environment;simulation software;Speed;System;Technology;technology development;Testing;Textiles;Thermodynamics;Time;Time Management;tool;United States National Institutes of Health;Universities;Work

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Science is no longer the pursuit by a single investigator, but rather that of a large network of investigators, with informatics playing a critical role in healthcare, clinical and translational research, and public health. We have been training the next generation of Biomedical Informatics and Data Science researchers in a diverse and inclusive environment where they acquire the essential skills to approach informatics challenges in a thorough, yet innovative, manner.

PI_NAMEs: NEMATI, SHAMIM  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Academia;Area;Award;Bioinformatics;biomedical informatics;California;Cells;Clinical Research;Cognitive Science;computer science;Cultural Backgrounds;Degree program;Education;Educational Background;Educational Curriculum;Educational process of instructing;Enrollment;Faculty;Grant;Health;Healthcare;Industry;Informatics;informatics training;innovation;Institution;Journals;learning strategy;Medical center;meetings;Nonprofit Organizations;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Productivity;professor;programs;Publications;Qualifying;Research;Research Methodology;Research Project Grants;Research Training;Science;symposium;Systems Biology;Training;Training and Education;Training Programs;Underrepresented Minority;United States National Library of Medicine;Universities;Vision;Woman

PROJECT_TITLE: San Diego Biomedical Informatics Education & Research (SABER)


NIH_SPENDING_CATS: Hematology

PHR: The NHLBI Short-Term Research Education Program to Increase Diversity in Health-Related Research at the University of Pennsylvania Perelman School of Medicine provides undergraduate students and research- oriented medical students from diverse, underrepresented backgrounds with a short-term, intensive summer research experience with the goal of increasing the pool of underrepresented students committed to careers in cardiovascular, pulmonary, and hematologic research.

PI_NAMEs: DELISSER, HORACE M (contact);SHIN, SUNNY ;SULLIVAN, KATHLEEN E

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Academic achievement;Area;Blood;Cardiovascular system;career;career development;clinically relevant;Data Analyses;design;disabled students;disadvantaged student;Discipline;education research;Educational workshop;effectiveness measure;Environment;Evaluation Research;Event;expectation;experience;Experimental Designs;Faculty;Fostering;Foundations;Funding;Goals;graduate school;graduate student;Health;Heart;Hematological Disease;Hematology;improved;Individual;interest;journal article;Journals;Knowledge;Laboratories;Laboratory Research;Learning;Lung;Marketing;medical schools;Medical Students;meetings;Mentors;Mission;Motivation;Museums;National Heart, Lung, and Blood Institute;Oral;peer networks;Pennsylvania;Philadelphia;Postdoctoral Fellow;posters;Preparation;Program Effectiveness;programs;Reading;recruit;Research;Research Project Grants;Research Training;responsible research conduct;Safety;Scholars Program;Series;skills;Sleep Disorders;social;Societies;Sports;Students;success;summer research;supportive environment;Time;Training;Training Activity;undergraduate research;undergraduate student;Underrepresented Students;Universities;Work


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The experiments I propose aim to understand the effects of critical period odor experience on both the development of the olfactory bulb circuit and changes in innate odor behaviors in adolescent and adult mice. The goals of my proposed research are to quantify the changes in input and output from the olfactory bulb glomeruli that detect an odorant following olfactory critical period exposure to this odorant; furthermore, I propose to see if behavioral and morphological changes in this circuit persist following olfactory bulb reinnervation. These experiments will advance our understanding of how experience during a developmental critical period impacts neural circuit development and lasting behaviors.

PI_NAMEs: GREGORY, JORDAN DURAN (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Adolescent;Adult;Amines;Anosmia;Apical;avoidance behavior;Axon;Behavior;Behavioral;behavioral response;Brain;Brain region;Calcium;career;Cells;Chronic;critical developmental period;critical period;Cues;Data;Dendrites;Detection;Development;Electrophysiology (science);Emotional;Environment;experience;experimental study;Exposure to;Faculty;Goals;Image;in vivo;inhibitory neuron;Instinct;Knowledge;Learning;Life;Maps;Mediating;member;Methimazole;mitral cell;Morphology;Mus;Natural regeneration;neural circuit;Odorant Receptors;Odors;olfactory bulb;olfactory bulb glomeruli;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Organizational Change;Output;Pathway interactions;Pattern;Phenethylamines;Play;postnatal period;preference;receptor;reinnervation;Reporting;Research;resilience;response;Role;Saline;Sensory;Slice;stem cells;Structure;T-Lymphocyte;Techniques;Testing;Time;Training;two-photon;Universities;voltage clamp

PROJECT_TITLE: Investigating the effects of olfactory critical period odorant exposure on the trace amine-associated receptor4 olfactory circuit


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: PROJECT NARRATIVE Great attention has been paid to the potential role of the external globus pallidus (GPe) in motor control and the aberrant GPe neuronal activity is closely associated with movement deficits in both PD patients and Parkinsonian animal models. Our preliminary results show that the activity of newly identified glutamatergic neurons in the GPe may contribute to PD-related behavioral dysfunction in dopamine-depleted mice. Thus, we will elucidate the anatomical and functional organization of GPe glutamatergic neurons to improve our understanding of GPe circuitry and its contribution to PD-related behavioral dysfunction in animal models for the progressive PD.

PI_NAMEs: LEUTGEB, STEFAN ;LIM, BYUNGKOOK  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Anatomy;Animal Model;Animals;associated symptom;Attention;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavioral;behavioral impairment;Behavioral Symptoms;Brain region;Cell Nucleus;cell type;cognitive function;Corpus striatum structure;Data;Disease;Dopamine;dopaminergic neuron;Dose;Electrophysiology (science);field study;flexibility;Functional disorder;Genetic;Genetic Suppression;Globus Pallidus;Glutamates;Heterogeneity;Human;improved;in vivo;Individual;Investigation;Mediating;Methods;mitopark mouse;Modeling;Molecular;molecular marker;Motor;motor behavior;motor control;motor deficit;mouse model;Movement;Movement Disorders;Mus;Nature;neural;neural circuit;neuroadaptation;neuromechanism;neuron loss;Neurons;Neurotoxins;novel;optogenetics;Output;Oxidopamine;Parkinson Disease;parkinsonian animal;Pathway interactions;Patients;Population;population based;Positioning Attribute;Progressive Disease;Reporting;Research;Role;Signal Transduction;Synapses;Techniques;Time;Viral

PROJECT_TITLE: Role of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine Depletion

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The two major challenges to the care of patients with acute interstitial nephritis result from the lack a non- invasive biomarker. These include the need to perform a kidney biopsy to establish the diagnosis and lack of information on patients most likely to benefit from therapy. Here we will enroll a cohort of participants with biopsy-proven, adjudicated acute interstitial nephritis and suitable controls to validate IL-9*TNF-α as a biomarker for both establishing the diagnosis of acute interstitial nephritis and to identify patients most likely to benefit from therapy.

PI_NAMEs: MOLEDINA, DENNIS G. (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Academic Medical Centers;Acute;acute care;Acute Renal Failure with Renal Papillary Necrosis;adjudication;Adrenal Cortex Hormones;Adult;Adverse event;Antibiotics;Area;Autoimmune Diseases;biobank;Biological Markers;biomarker identification;Biopsy;Blinded;Characteristics;Chronic Kidney Failure;Clinical;clinical application;clinical biomarkers;clinical care;Clinical Trials;cohort;cytokine;Diagnosis;diagnostic biomarker;Diagnostic tests;Disease;Enrollment;eosinophil;Evaluation;experience;Fibrosis;Future;Glomerular Filtration Rate;Goals;Hemorrhage;Histologic;Hospitals;Human;Image;Immune;Immune checkpoint inhibitor;Immune response;impression;improved;indexing;Infiltration;Inflammation;Injury to Kidney;Interleukin-9;Interstitial Nephritis;Kidney;kidney biopsy;Kidney Diseases;Leukocytes;Measurement;Mediating;Modeling;Monitor;Multicenter Studies;novel;Observational Study;Outcome;Participant;Pathologist;Patient Care;patient subsets;Patients;Pharmaceutical Preparations;Plasma;predicting response;predictive marker;Process;Proton Pump Inhibitors;Recovery;Recovery of Function;renal damage;Renal function;Resources;response;Risk;ROC Curve;Sampling;Sarcoidosis;Schedule;Sensitivity and Specificity;Severities;Sjogren's Syndrome;Specific qualifier value;standard of care;Subgroup;Symptoms;Testing;Therapeutic immunosuppression;Time;Time Management;TNF gene;treatment effect;Treatment Side Effects;Urine;Withdrawal

PROJECT_TITLE: Biomarkers for acute interstitial nephritis in humans

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Biliary tract cancer (BTC), the second most common primary hepatobiliary cancer worldwide, is highly fatal; approximately 90% of BTC patients die within five years after diagnosis. Therefore, primary and secondary prevention measures are vital to reduce its mortality rate. Herein, we propose a well-powered study to systematically search and validate novel biomarkers for BTC risk in order to design cost-effective strategies for BTC prevention.

PI_NAMEs: CAI, QIUYIN ;SHU, XIAO-OU  (contact);ZHENG, WEI

PROGRAM_OFFICER_NAME: KALIA, SARAH SUJATA

PROJECT_TERMS: absorption;Anabolism;Asian;Asian population;bile duct;Bile Duct Carcinoma;biliary tract;Biliary Tract Cancer;Biological;Biological Assay;Biological Markers;Biology;biomarker identification;biomarker validation;Black Populations;Blood;Blood specimen;cancer biomarkers;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer prevention;cancer risk;case control;Cessation of life;Cholecystitis;Chronic;cost effective;cost efficient;Data;data harmonization;Death Rate;design;Diabetes Mellitus;Diagnosis;Diagnostic;Dietary Practices;epidemiology study;Etiology;Extrahepatic;Fatty acid glycerol esters;Feasibility Studies;gallstone disease;Genetic;Genetic Risk;genetic variant;genome wide association study;genomic data;hepatobiliary cancer;Hispanic Populations;Human;improved;Incidence;Individual;Inflammation;instrument;Investigation;liver function;Maintenance;Malignant neoplasm of gallbladder;Malignant Neoplasms;Mendelian randomization;Metabolic;Metabolism;metabolome;metabolomics;Methodology;Modeling;Morbidity - disease rate;mortality;multiple datasets;Nature;novel;novel marker;Obesity;Pathogenesis;Patients;Pilot Projects;Play;Population;Prevention Measures;Prevention strategy;Primary Prevention;Prospective, cohort study;Quantitative Trait Loci;racial difference;racial population;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction model;risk variant;Role;Sample Size;Sampling;Secondary Prevention

PROJECT_TITLE: Searching the blood metabolome to identify risk biomarkers for biliary tract cancer

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative The proposed research is relevant for public health because Lewy pathology is a central feature of several devastating neurodegenerative diseases and understanding the disease process underlying Lewy pathology will open new avenues of therapeutic development for those diseases. This proposal is relevant to the NIH’s mission of seeking fundamental knowledge to reduced illness and disability.

PI_NAMEs: KILLINGER, BRYAN  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: alpha synuclein;Antigens;Biochemical;Biotinylation;Brain;Brain Diseases;Brain region;Catalogs;cell injury;Cell Physiology;Chemicals;Clinical;Consensus;Dementia with Lewy Bodies;Development;disability;Disease;Disease Progression;Environment;Future;Goals;Human;human disease;In Situ;innovation;insight;Knowledge;Label;Lewy body pathology;Maps;Measures;Mechanics;Microscopy;Mission;Modeling;Molecular;Nervous System Disorder;Neurodegenerative Disorders;novel;novel therapeutic intervention;Organelles;Outcome;Parkinson Disease;Pathologic;Pathologic Processes;Pathway interactions;Phenotype;prevent;Process;protein protein interaction;Proteomics;Public Health;Research;response;Rodent;Rodent Model;Role;Sampling;Structure;synucleinopathy;Techniques;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;translational model;United States National Institutes of Health

PROJECT_TITLE: PROTEOMIC MAPPING OF PATHOLOGICAL INTERACTIONS ACROSS THE SYNUCLEINOPATHY BRAIN

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE: Transcriptional regulatory networks that control context-specific gene expression levels play a major role in defining the cell type identity. This project will develop and apply novel computational tools for single cell omic datasets to identify regulatory networks for individual cell types and examine how they change across related cell types. Our tools and resources will provide a broadly applicable framework to study network dynamics and how they affect normal and disease processes in mammalian species.

PI_NAMEs: ROY, SUSHMITA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Active Learning;Address;Affect;Agreement;ATAC-seq;Automobile Driving;Basic Science;Bayesian Network;Biological Assay;Biological Process;causal variant;Cell Fate Control;cell fate specification;Cell Lineage;Cell Reprogramming;cell type;Cells;Chromosome Mapping;CISH gene;Clustered Regularly Interspaced Short Palindromic Repeats;computerized tools;Computing Methodologies;Data;data integration;Data Set;Development;dimension reduction;Disease;disease model;Distal;Enhancers;experimental study;Gene Expression;Gene Expression Profile;gene interaction;gene regulatory network;Generations;Genes;genetic regulatory protein;Genetic Transcription;Genomics;Goals;Gold;Graph;improved;Individual;induced pluripotent stem cell;insight;Joints;Learning;Mammalian Cell;Measurement;Measures;Methods;Modeling;molecular phenotype;Multiomic Data;multiple omics;multitask;Mus;network models;novel;Nucleic Acid Regulatory Sequences;Output;Patients;Performance;Play;Process;promoter;Publishing;Regulator Genes;Resolution;Resources;Role;Sampling;single cell ATAC-seq;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;Specificity;Structure;System;Techniques;Technology;tool;transcription regulatory network;transcriptome;Transgenes;Translational Research

PROJECT_TITLE: Defining gene regulatory networks controlling cell fate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(02)M]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative Kaposi's sarcoma (KS) is one of the most common cancers in sub-Saharan Africa, and, like other tumors, early detection can lead to improved survival. We propose to develop, manufacture, and perform a multi-site sub-Saharan African clinical validation of KS-COMPLETE – the first true sample-to-answer diagnostic system for Kaposi's Sarcoma (KS). This system will enable physicians to diagnose KS at the point-of-care in less than 60 minutes – compared with the 2 weeks traditional pathology often requires – significantly improving patient outcomes.

PI_NAMEs: CESARMAN, ETHEL ;ERICKSON, DAVID CARL (contact);MARTIN, JEFFREY N;SEMEERE, AGGREY SEMWENDERO

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: accurate diagnosis;Adoption;Africa;Africa South of the Sahara;African;Biopsy;chemotherapy;Clinical;clinical efficacy;clinical research site;Communicable Diseases;cost;Dermatology;Detection;Development;Diagnosis;Diagnostic;diagnostic platform;Diagnostic Procedure;Diagnostic tests;Discipline;DNA;Early Diagnosis;Engineering;Enrollment;Epidemiology;Evaluation;Exclusion;field study;Genetic Markers;Goals;Histopathology;Hour;Human;Human Herpesvirus 8;Immunohistochemistry;improved;Indiana;Infrastructure;Kaposi Sarcoma;low and middle-income countries;Malignant Neoplasms;Manuals;manufacture;Medicine;men;Methods;Multi-Institutional Clinical Trial;mycobacterial;Nature;Nucleic Acids;operation;Outcome;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Phase;Physicians;point of care;Point of Care Technology;point-of-care diagnosis;point-of-care diagnostics;Point-of-Care Systems;Positioning Attribute;prevent;Process;professor;prototype;Punch Biopsy;Qualifying;rapid diagnosis;Research;Rwanda;Sampling;Sensitivity and Specificity;Series;Site;Skin;skin biopsy;skin disorder;Solid;System;Tanzania;Techniques;Technology;Time;Training;tumor;Uganda;Universities;uptake;Validation;Viral;Woman;Work

PROJECT_TITLE: Rapid Sample-to-Answer Diagnosis of Kaposi's Sarcoma Across Sub-Saharan Africa using KS-COMPLETE


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PUBLIC HEALTH RELEVANCE Colon cancer is a deadly cancer and new treatments are needed. Iron accumulation is an essential mechanism, which drives colon cancer progression. This grant will characterize mechanisms critical for iron- mediated growth, and identify new targets for the prevention and treatment of colon cancer.

PI_NAMEs: SHAH, YATRIK M (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: addiction;aerobic glycolysis;antiporter;Apical;Area;Binding;Biomass;Bypass;cancer cell;Cancer Cell Growth;casein kinase;CDC2 gene;Cell Death;cell injury;Cell model;Cell Proliferation;Cells;Cellular Metabolic Process;Citric Acid Cycle;Colon;colon cancer progression;colon cancer treatment;colon carcinogenesis;Colon Carcinoma;Colonic Adenoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer risk;Critical Pathways;Cystine;Data;Deferoxamine;Development;Diet;dietary restriction;DNA Damage;Drug Targeting;Early Diagnosis;Embryo;epidemiologic data;Epithelium;Foundations;Generations;Genetic;Genetic Predisposition to Disease;Glutamates;glutathione peroxidase;Goals;Grant;Growth;Hepatic;hepcidin;Hormones;Human;Hydroxyl Radical;Incidence;Inflammatory;Intestines;Iron;Iron Chelating Agents;Iron Chelation;iron supplementation;JAK1 gene;Leucine Zippers;Lipid Peroxides;Liver;Malignant Neoplasms;Mediating;Metabolism;metal transporting protein 1;Micronutrients;Modeling;mouse model;Mucous Membrane;Mus;new therapeutic target;Normal Cell;novel;novel therapeutics;nuclear factor-erythroid 2;Nutritional Requirements;Oncogenic;Organoids;oxidative damage;p21 activated kinase;Pathogenesis;Pathway interactions;Patients;Phosphotransferases;Post-Translational Protein Processing;Prevention;Production;Proliferating;Protein Export Pathway;protein expression;Proteins;public health relevance;Radiosensitization;Reaction;Repression;Research;Resistance;resistance mechanism;Role;Signal Transduction;Site;SLC11A2 gene;STAT3 gene;Superoxides;System;targeted treatment;Testing;therapeutic target;Toxic effect;transcription factor;tumor;uptake;Work

PROJECT_TITLE: Understanding the mechanisms of iron addiction in colon cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE We are developing advanced machine learning approaches and tools for understanding the link between mo- lecular function and phenotype and to guide experimental data collection within the IGVF Consortium. These tools will assist in determining whether and how the observed differences on a human genome give rise to a risk of a disease or other condition of clinical interest. Our methods are distributable on the internet and will be made widely available.

PI_NAMEs: RADIVOJAC, PREDRAG  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Active Learning;active method;Address;Adopted;Area;assay development;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;biological systems;Biology;Biotechnology;California;Clinical;Clinical assessments;clinical care;clinical implementation;Communities;Complex;Computer Models;cost;Data;Data Collection;Data Set;design;Disease;diverse data;DNA Sequence Alteration;Environment;Evaluation;exome sequencing;Experimental Designs;experimental study;functional genomics;Genes;Genetic Models;genetic variant;Genome;genome sequencing;Genomic medicine;Genomic Segment;genomic variation;Genomics;Goals;Health system;Human;human disease;Human Genome;improved;innovation;insight;interest;Internet;Knowledge;Leadership;Learning;Link;Machine Learning;machine learning method;Measures;Medical Genetics;Medicine;Mendelian disorder;method development;Methodology;Methods;Mission;model development;model organism;Modeling;Modernization;Molecular;Molecular Biology;Molecular Conformation;molecular modeling;Molecular Structure;Mutation;mutation screening;Nature;next generation;novel;Outcome;Output;Paper;Pathogenicity;Pharmacogenetics;Phenotype;Positioning Attribute;predictive modeling;predictive tools;protein structure;Publishing;Regulation;Research;Research Personnel;Resource Allocation;Resources;Risk;RNA Splicing;Site;Statistical Models;supervised learning;System;Technology;Tissues;tool;Training;trait;Transcriptional Regulation;Universities;Validation;Variant;Washington;Work

PROJECT_TITLE: Supporting IGVF by modeling genetics, function, and phenotype with machine learning


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: This study will examine the association between prenatal, early childhood, and adult metal exposures and late life cognitive function, as well as whether early life exposures modify effects of adult exposures. In a subset of a population that donated their baby teeth as children and is now in their 60's and 70's, we will analyze metals in those previously collected baby teeth to assess early life exposures and in repeated toenail samples for adult exposures and relate those to performance on cognitive tests. We will also assess micro RNA (miRNA) profiles from extracellular vesicles in blood of the adults to examine possible epigenetic mechanisms underlying associations.

PI_NAMEs: WEISSKOPF, MARC G (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Ablation;Address;Adult;age related;aging brain;aging population;Alzheimer's Disease;American;Animal Experimentation;Animals;Biological Markers;Blood;Blood specimen;Cells;Child;Cognitive;Cognitive aging;cognitive development;cognitive function;cognitive testing;Cohort Studies;cost estimate;Data;Dementia;Dental Enamel;Deposition;Development;Disease;early childhood;early detection biomarkers;early life exposure;Economic Burden;economic cost;Elderly;Encapsulated;Enrollment;Environmental Exposure;Epigenetic Process;Exposure to;extracellular vesicles;Fluorescence;Gene Expression;Health;Human;human old age (65+);human study;Impaired cognition;in utero;Individual;Inductively Coupled Plasma Mass Spectrometry;Intervention;Lasers;Late Effects;late life;lead exposure;Life;Link;Lipid Bilayers;Measures;men;Metal exposure;Metals;MicroRNAs;Modification;nanoscale;Neurons;novel marker;older adult;Older Population;Outcome;Participant;particle;Pathology;Patients;Performance;Population;postnatal;prenatal;Prevention;Process;Public Health;Questionnaires;recruit;Risk;Risk Factors;Roentgen Rays;Role;Sampling;Serum;Signal Transduction;Structure of nail of toe;Testing;Time;Tooth structure;United States;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Metals and Developmental Origins of Late Life Cognitive Function

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Microbiome;Nanotechnology

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The natural environment is intrinsically heterogenous yet our control of concentrations for chemical species is limited at microscopic level. The proposed research is relevant to the mission of the NIH because it describes the development of technology that will expand our capability of controlling chemical concentration profiles in a variety of microbial systems relevant to the public health. The research described here will enable a deeper understanding of disease-related microbial systems and help to formulate strategies to combat diseases.

PI_NAMEs: LIU, CHONG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Affect;Algorithms;biomaterial compatibility;Chemicals;Chemistry;combat;Devices;Dioxygen;Disease;Electrochemistry;Electrodes;Ensure;Environment;extracellular;gut microbiota;Heterogeneity;In Vitro;Individual;Inorganic Chemistry;Length;Machine Learning;Methods;microbial;Microbial Biofilms;microbiota;Microelectrodes;microorganism;microorganism culture;Microscopic;Mission;nano;nanomaterials;Nature;Oxidation-Reduction;programs;Property;Public Health;Reaction;Reactive Oxygen Species;Research;response;Shapes;simulation;Social Behavior;Spatial Distribution;spatiotemporal;Specificity;spectroscopic imaging;Surface;System;technology development;tool;Transition Elements;United States National Institutes of Health;Work

PROJECT_TITLE: Spatiotemporal control of concentration gradients with electrochemistry in extracelluar space

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

PHR: Even though smoking in pregnancy harms the baby, pregnant women struggle to quit smoking. We are coupling a texting program that helps pregnant women quit with a program to teach obstetric clinicians how to counsel women to quit. We expect that women will be most likely to quit when they receive both the texting and are counseled by a clinician who has learned effective communication.

PI_NAMEs: CHANG, JUDY C;POLLAK, KATHRYN I (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Abstinence;Affect;arm;Biochemical;Clip;Communication;Communication Programs;comparison control;cost;Counseling;Coupling;design;Discipline of obstetrics;Double Effect;Educational process of instructing;Equation;Evidence based intervention;Exercise;expectation;Feedback;Guidelines;Health Care Costs;improved;Individual;individualized feedback;Infant Care;infant morbidity/mortality;Infant Mortality;Intervention;intervention effect;Learning;Light;Low Birth Weight Infant;maternal morbidity;Meta-Analysis;Modeling;Mothers;neonatal morbidity;Oncologist;Online Systems;Outcome;Outcome Assessment;Patients;pediatrician;Perception;Perinatal;Phase;pilot test;post intervention;Postpartum Abstinence;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;primary outcome;programs;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;secondary outcome;Self Efficacy;Site;skills;Smoke;Smoking;smoking abstinence;smoking cessation;smoking during pregnancy;Suggestion;Testing;Text;Text Messaging;text messaging intervention;theories;Touch sensation;Training;Training Programs;treatment arm;United States;web-based intervention;Woman;Work

PROJECT_TITLE: Testing a Clinician and Patient Intervention to Promote smoking Cessation Among Pregnant Women

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: The goal of the training program is to train pediatricians for careers as investigators who will address the present and future challenges of childhood infections. Academic physicians with research interests in Pediatric Infectious Diseases are urgently needed to meet the ongoing and emerging threats to child health of the Covid- 19 pandemic, congenital HIV infection, childhood malaria and tuberculosis, diarrheal diseases, and respiratory infections—critical problems that are further complicated by increasing antimicrobial resistance, emerging infectious diseases, and societal opposition to childhood vaccines.

PI_NAMEs: KIM, DENNIS H (contact);WESSELS, MICHAEL R

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Childhood;Infectious Diseases Research;Research Training

PROJECT_TITLE: Pediatric Infectious Diseases Research Training

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative. Programmed death ligand-1 (PD-L1) is an immune checkpoint protein involved in tumor immune suppression and expressed in a variety of cancers. PD-L1 detection by immunohistochemistry is used to guide immune checkpoint therapies, however few tools exist to quantify total PD-L1 levels in the whole body and fewer to do so non-invasively. We will develop and translate a PD-L1 imaging agent to guide cancer immunotherapy, and create an easy to use kit formulation for improved dissemination and broad access.

PI_NAMEs: NIMMAGADDA, SRIDHAR  (contact);ROWE, STEVEN P

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;Affinity;Biological;Biological Markers;biomarker panel;Biopsy;cancer care;cancer immunotherapy;Cancer Model;Cancer Patient;checkpoint therapy;Chemistry;Clinic;Clinical;clinical application;Clinical Management;clinical translation;Clinical Trials;Collaborations;contrast imaging;Data;design;Detection;Disease;dosimetry;Effectiveness;Evaluation;Excipients;experience;first-in-human;Formulation;Freeze Drying;Gallium;Generations;Goals;Human;human study;humanized mouse;Image;imaging agent;imaging modality;immune cell infiltrate;immune checkpoint;Immunohistochemistry;Immunosuppression;Immunotherapy;improved;In Situ;in vivo;Industry;Investigational New Drug Application;Iowa;Label;Location;Malignant Neoplasms;Measures;Molecular;Molecular Target;mouse model;multidisciplinary;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;patient stratification;patient subsets;Patients;Peptides;Performance;pharmacodynamic biomarker;Pharmacodynamics;Pharmacologic Substance;Positron-Emission Tomography;predicting response;predictive marker;Preparation;programmed cell death ligand 1;Proteins;Radiochemistry;Radiopharmaceuticals;radiotracer;Reporting;Research;Research Personnel;Resistance;response;Safety;Sampling Errors;Specificity;Testing;theranostics;Therapeutic;Time;Tissues;tool;Tracer;Translating;treatment choice;treatment optimization;tumor;tumor heterogeneity;Universities;Validation;Vial device;Xenograft procedure

PROJECT_TITLE: Clinical translation of a PD-L1 PET tracer to optimize immune checkpoint therapy in patients with non-small cell lung cancers


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: Project Narrative Manganese (Mn) is an established neurotoxicant that affects the same motor and cognitive brain pathways affected in Parkinson disease (PD), notably the nigrostriatal system. In this renewal, we will use positron emission tomography (PET) brain imaging to investigate the role of Mn in degeneration of the dopaminergic system and the potential neuroinflammatory mechanism. Successful completion of these aims will provide a unique opportunity to understand the mechanism of an important environmental neurotoxicant that targets the nigrostriatal brain pathway, which is the same pathway affected in PD.

PI_NAMEs: RACETTE, BRAD A (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Affect;Basal Ganglia;Binding;Biological Markers;bone;Brain;Brain imaging;brain pathway;Brain region;Clinical;clinical phenotype;clinically relevant;Cognitive;cohort;Corpus striatum structure;Data;dihydrotetrabenazine;Dopamine;Dose;Exhibits;follow-up;Functional disorder;glial activation;Globus Pallidus;Image;imaging biomarker;improved;in vivo;insight;Laboratory Finding;Levodopa;longitudinal positron emission tomography;Manganese;Measures;Mediating;Mediation;Mediator;Motor;Neurodegenerative Disorders;neuroinflammation;neurotoxicity;Neurotoxins;Neutrons;nigrostriatal degeneration;nigrostriatal system;Occupational;Outcome;Parkinson Disease;Parkinsonian Disorders;Participant;Pathogenesis;Pathway interactions;Pattern;Policies;Positron-Emission Tomography;putamen;radioligand;rate of change;receptor;receptor binding;Research;response;Role;Sample Size;Scanning;Substantia nigra structure;System;Thalamic structure;Time;Up-Regulation;uptake;vesicular monoamine transporter 2;Work;worker safety;Workplace

PROJECT_TITLE: Imaging Biomarkers of Neurotoxicity in Welders


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The goal of this proposal is to define specific cellular and circuit mechanisms of plasticity resulting from early life traumatic stress. The results of these studies will help improve our understanding of how early life experience leads to adult emotional dysfunction.

PI_NAMEs: CLEM, ROGER L (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adrenergic Agents;Adrenergic Receptor;Adult;age related;Amygdaloid structure;Animals;Anxiety;approach/avoidance behavior;attenuation;avoidance behavior;Behavior;Behavioral;behavioral phenotyping;behavioral response;Biological Assay;Biological Factors;Brain region;Calcium;Cells;Childhood;Data;Development;Disease;early adolescence;early life adversity;early onset;Early-life trauma;Electrophysiology (science);emotion regulation;Emotional;Exhibits;experience;Exposure to;Fiber;foot;Functional disorder;genetic manipulation;Goals;Human;Image;immature animal;Immunohistochemistry;improved;in vivo;Incidence;Infusion procedures;innovation;Life;Life Experience;Light;locus ceruleus structure;Measures;Medial;Mediating;Membrane;Mental Depression;Mental disorders;Mus;Neurons;neurotransmission;noradrenergic;Norepinephrine;optogenetics;Outcome;Pathway interactions;Patients;pediatric trauma;Pharmaceutical Preparations;pharmacologic;Phenotype;Photometry;Physical activity;Physiological;Play;postnatal;Predisposition;Prefrontal Cortex;Process;Property;Recording of previous events;Regulation;response;Risk Factors;Rodent;Role;Severities;Shock;Signal Transduction;Slice;Stress;Structure;Synapses;Synaptic Transmission;Testing;Time;Translating;Trauma;traumatic stress;treatment response

PROJECT_TITLE: Cellular substrates of early life trauma

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Diabetes;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because there is currently no clear understanding of the mechanistic underpinnings and roles of different inhibitory somatostatin receptor subtypes in the alpha and beta cells of the pancreatic islet. The mechanisms proposed complement existing understandings of paracrine signaling within the islet and integrate these with novel observations of filamentous actin reorganization following somatostatin receptor activation. Thus, the proposed research is relevant to NIDDK’s mission because it directly addresses the mechanism by which somatostatin inhibits insulin and glucagon secretion, which can be leveraged to improve the quality of life for millions of Americans with diabetes.

PI_NAMEs: HART, RYAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Actins;Address;Affect;Agonist;Alpha Cell;American;antagonist;Attenuated;attenuation;Automobile Driving;Beta Cell;Calcium;Cell surface;cell type;Cells;Cilia;Complement;Complex;Coupled;Cyclic AMP;Data;Diabetes Mellitus;Endocrine System Diseases;Exocytosis;experimental study;F-Actin;Family;Functional Imaging;Genetic Transcription;Glucagon;Glucose;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Hormone secretion;Hormones;Hyperinsulinism;Hypoglycemia;Image;imaging approach;improved;Individual;innovation;Insulin;insulin secretion;islet;Islet Cell;Islets of Langerhans;Kinetics;Knowledge;live cell imaging;Mechanics;Mediating;Metabolic;Mission;Molecular;Monomeric GTP-Binding Proteins;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;next generation sequencing;novel;Outcome;Paracrine Communication;peptide hormone;pharmacologic;polymerization;Polymers;Population;Public Health;Quality of life;receptor;Receptor Activation;Reporter;Research;Resolution;response;rho;Role;Secretory Vesicles;selective expression;sensor;Signal Transduction;Somatostatin;Somatostatin Receptor;somatostatin receptor 1;spatiotemporal;Specificity;SSTR2 gene;SSTR3 gene;Structure of beta Cell of islet;targeted treatment;Testing;Time;Tissues;transcriptome;transcriptomics;Transgenic Mice;type I and type II diabetes;United States;Weight

PROJECT_TITLE: Mechanisms of Somatostatin-Mediated Inhibition of Insulin and Glucagon


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Black and Latina women experience a higher burden of pregnancy complications, maternal mortality, and preterm birth compared to white women due to the significant impact of racism and racialized inequity. Yet, no studies have examined whether experiences of racism prenatally affect fetal health and development through a process of “biological embedding” of racism measured daily during pregnancy. The proposed multi-site and rigorously-designed longitudinal research aims to advance understanding of racism-related health disparities as well as modifiable stress-buffering factors in pregnant Black and Latina women and infants.

PI_NAMEs: CARTER, SIERRA E (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Adult;Adult women;adverse birth outcomes;Affect;African American;allostatic load;American;Area;Behavior;Biological;Biological Process;Biology;Birth;Black race;black women;Blood Pressure;Buffers;care systems;Child;Cities;coping;Coping Skills;Development;diaries;Discipline of obstetrics;Discrimination;Disparity;dyadic interaction;early childhood;Enrollment;ethnic identity;Ethnic Origin;European;experience;Exposure to;Family health status;fetal;Fetal autonomic nervous system;Fetal Development;Fetal health;Fetal Heart Rate;Fetus;follow-up;Foundations;Future;Generations;Goals;healing;Health;Health Care Costs;health disparity;health inequalities;health of the mother;Heart Rate;heart rate variability;high risk;Home;Hour;Hypertension;indexing;Individual;Infant;infant outcome;innovation;Institution;intergenerational;Intervention;Interview;Knowledge;Latina;Life;Literature;longitudinal design;Longitudinal Studies;Low Birth Weight Infant;marginalization;Maternal Mortality;Maternal Physiology;Measurable;Measures;Medical;Methods;Midwife;modifiable behavior;Mothers;Nature;neglect;neurobehavior;neurobehavioral;neurodevelopment;Neurodevelopmental Problem;Newborn Infant;Outcome;Outcome Measure;Personal Satisfaction;Persons;Physiological;Physiology;Pregnancy;Pregnancy Complications;Pregnancy Trimesters;pregnant;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Process;programs;Protocols documentation;Psychophysiology;Qualitative Methods;Questionnaires;Race;racial discrimination;racial disparity;racial identity;racism;recruit;Reporting;Research;Review Literature;Risk;Sampling;Second Pregnancy Trimester;Sex Differences;Site;Social support;Sodium Chloride;Stress;stress management;stress reactivity;stressor;Structure;Testing;theories;Third Pregnancy Trimester;Time;transmission process;Validation;White Women;Woman;women of color;Women's cohort;Women's mortality;women's outcomes;Work

PROJECT_TITLE: Advancing understanding of racism-related health disparities beginning before birth: A multisite study with Black and Latina pregnant women

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Nanotechnology;Neurosciences;Opioid Misuse and Addiction;Opioids;Stroke;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This application aims to investigate the impact of HIV brain infection and prescription opioids on ischemic stroke, a major co-morbidity in the infected population and opioid abusers. The central hypothesis is that HIV and prescription opioids activate inflammasome in the CNS that can worsen stroke outcome, including post-stroke HIV reactivation in the CNS and egress into the periphery. The obtained results will have a potential to be a major breakthrough by its focus on novel mechanisms underlying vascular comorbidity, such as ischemic stroke, in HIV infection and opioid abuse.

PI_NAMEs: TOBOREK, MICHAL  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Antioxidants;antiretroviral therapy;Area;Belief;Blood Vessels;Brain;Cells;Cerebrum;Chronic;Clinical;comorbidity;compare effectiveness;Complex;Data;Development;Drug abuse;Drug toxicity;Event;Exposure to;Grant;HIV;HIV Infections;IL18 gene;improved;Infection;Inflammasome;Inflammatory;innovation;insight;interest;Interleukin-1 beta;ischemic injury;Ischemic Stroke;Laboratories;Link;Mitochondria;mitochondrial dysfunction;mitochondrial therapeutics;Morphine;Mus;nanoparticle;Nanotechnology;Nature;neuroinflammation;novel;Opioid;opioid abuse;Opioid abuser;opioid exposure;Outcome;Oxycodone;Pathologic;Patients;Pattern recognition receptor;Population;post stroke;Predisposition;prescription opioid;Process;Publications;Publishing;Reaction;Recovery;Reporting;Research;response;Role;Stimulus;Stroke;stroke outcome;stroke recovery;Substance abuse problem;Text;therapeutic effectiveness;Therapeutic Intervention;Time;Tissues;Toxic effect;virtual;Work

PROJECT_TITLE: Targeting Inflammasomes in Substance Abuse and HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_STATE: CA

PHR: Narrative The goal of our proposed MARC program is to increase the diversity of students pursuing a PhD in a STEM field and a research career in the biomedical sciences. To achieve this goal, we have developed a series of activities for underrepresented, socioeconomically disadvantaged, and disabled undergraduates. These activities are designed to facilitate the development of their talent and professional skills in preparation for excelling in their subsequent PhD (or MD/PhD) programs and careers in biomedical science.

PI_NAMEs: GOMES, ALDRIN V. (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Bachelor's Degree;Biomedical Research;California;career;CCL7 gene;collaborative environment;Communication;Communities;Data Analyses;Development;Discipline;Doctor of Philosophy;Ethics;experience;Experimental Designs;faculty research;Goals;graduate school;graduate student;Learning;Measurable;Mentors;Mentorship;Mission;Oral;outreach;Process;programs;recruit;Research;Research Design;Science;Self Efficacy;skills;social;Social support;Source;STEM field;student participation;student retention;Students;symposium;Time;Training Programs;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: MARC at University of California, Davis

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_DEPT: UROLOGY

PHR: Intratumoral androgen biosynthesis is well characterized as one of the important mechanisms of castration resistant prostate cancer (CRPC). This application is aimed to determine the roles of steroid sulfatase (STS) in progression and resistance to next-generation anti-androgen therapy, and develop novel STS inhibitors to target STS activity to potentially inhibit CRPC growth and reverse treatment resistance.

PI_NAMEs: GAO, ALLEN C. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;advanced prostate cancer;Androgen Antagonists;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgenic;Androgens;Anti-androgen Therapy;Biological Availability;Cancer Patient;carcinogenesis;cell growth;Cell Line;Cells;Clinical;Clinical Treatment;CYP17A1 gene;Data;Databases;dehydroepiandrosterone;design;Down-Regulation;effective therapy;enzalutamide;Enzymes;experience;Generations;Genetic Transcription;Growth;Hydroxysteroid Dehydrogenases;improved;In Vitro;in vivo;in vivo Model;inhibitor;Intervention;intratumoral androgen;Investigation;knock-down;LNCaP;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Mutation;next generation;novel;Organic Anion Transporters;overexpression;Oxidoreductase;patient derived xenograft model;Pharmaceutical Preparations;Plasma;Play;Production;prostate cancer cell;prostate cancer progression;Resistance;Resistance development;Role;Safety;Sampling;Signal Transduction;Small Interfering RNA;small molecule inhibitor;Source;Specimen;Stanolone;Steroid biosynthesis;Steroids;Sulfatases;System;Testing;Testosterone;therapeutic target;therapy resistant;Treatment Failure;treatment response;treatment strategy;Variant;VCaP;Xenograft procedure

PROJECT_TITLE: Therapeutic targeting steroid sulfatase for advanced prostate cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Organ Transplantation;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Long-term survival after heart transplantation continues to be limited both by immune-mediated damage to the transplant and by adverse effects caused by calcineurin inhibitors (CNIs), which are part of nearly all immunosuppressive regimens in heart transplantation. In this application we propose to use belatacept, initially with a CNI that will be slowly reduced and then stopped, to achieve CNI-free immunosuppression (with mycophenolate mofetil and prednisone), which we hypothesize will prevent rejection, suppress the development of antibodies that cause damage to the transplant, and eliminate the adverse effects of CNIs together improving survival after heart transplantation. The accompanying studies will inform as to why the approach did or did not work and determine whether non-invasive biomarkers can be used to predict clinical outcomes.

PI_NAMEs: HABAL, MARLENA  (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acute;Adherence;Adrenal Cortex Hormones;Adverse effects;Antibodies;arm;Autoantibodies;Autoantigens;B-Lymphocyte Subsets;Biological Assay;Biological Markers;Biopsy;Calcineurin inhibitor;CD28 gene;CD80 gene;CD86 gene;cell free DNA;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Trials;Communities;cost;Cytometry;Data;design;Development;Diabetes Mellitus;donor-specific antibody;efficacy testing;Event;experience;FDA approved;Foundations;Freedom;Goals;Graft Survival;Health;heart allograft;Heart Transplantation;Helper-Inducer T-Lymphocyte;Human Herpesvirus 4;Image;Immune;Immune response;Immunology;Immunosuppression;improved;Individual;Injury to Kidney;Kidney;kidney fibrosis;Kidney Transplantation;Kinetics;Licensing;Link;Mediating;Metabolic;Molecular;Morbidity - disease rate;Multi-Institutional Clinical Trial;Multicenter Trials;mycophenolate mofetil;neurotoxicity;novel;Outcome;Pathogenicity;Patient Compliance;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Populations at Risk;post-transplant;potential biomarker;PPP3CA gene;predict clinical outcome;Prednisone;prevent;primary endpoint;Protocols documentation;Randomized;Randomized, Controlled Trials;Regimen;Regulatory T-Lymphocyte;Renal function;response;Risk;Safety;safety outcomes;secondary endpoint;seropositive;Signal Transduction;Site;standard of care;Survivors;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Tacrolimus;Testing;Time;transcriptomics;Translating;Transplant Recipients;Transplantation;Tremor;trial design;Vascular Diseases;virtual;Withdrawal

PROJECT_TITLE: Safety and efficacy of Belatacept in heart transplantation


ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Electroencephalography (EEG) is an essential clinical diagnostic and research tool in neurology and cognitive neuroscience, but the technology has essentially remained unchanged for the past 100 years. In this proposal, we aim to develop “next-generation” dry EEG using MXene, a material with high compatibility with biology and magnetic fields (e.g., like those in magnetic resonance imaging, MRI), high stability, is convenient to set up and clean up, and is low-cost relative to other devices. This project will offer researchers and clinicians a high-resolution dry EEG technology that overcomes many of the limitations of current devices used in hospitals and laboratories around the world.

PI_NAMEs: MEDAGLIA, JOHN ;VITALE, FLAVIA  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3D Print;Adoption;Ambulatory Care Facilities;American;Behavior;Behavioral;Benchmarking;Biological Markers;Biology;biomaterial compatibility;Brain;brain electrical activity;Brain Injuries;Brain Mapping;brain research;Bypass;Carbon;Characteristics;Clinical;clinical diagnostics;Clinical Research;Cognitive;cognitive neuroscience;cognitive process;Corrosion;cost;cost effective;Data;density;design;Devices;Diagnostic;Dryness;electric impedance;Electrodes;Electroencephalography;Epilepsy;executive function;fabrication;flexibility;Frequencies;Functional Magnetic Resonance Imaging;Gel;Generations;Geometry;Hospitals;human subject;Image;Individual;Ink;innovation;irritation;Laboratories;magnetic field;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Magnetoencephalography;manufacture;manufacturing cost;Maps;Metals;Methods;Molds;Monitor;Morphologic artifacts;Motor;MRI Scans;multidisciplinary;multimodality;nanomaterials;Nervous System Disorder;neural;neurological rehabilitation;Neurologist;Neurology;neurophysiology;neuroregulation;Neurosciences;next generation;Noise;novel;Paste substance;Pathologic;Patient Recruitments;Patients;Performance;Pilot Projects;portability;Preparation;prevent;Printing;Process;Property;Radiology Specialty;rehabilitation research;Rehabilitation therapy;relative cost;Research;Research Personnel;Resolution;Rest;Risk;Sampling;scale up;Scalp structure;Shapes;Signal Transduction;Silver;silver chloride;Skin;Sleep Disorders;Societies;spatiotemporal;Stroke;System;technological innovation;Technology;Temperature;Testing;Time;tool;Training;Transcranial magnetic stimulation;usability;Visual;Water

PROJECT_TITLE: Validating MXene Electrodes for Next-Generation Electroencephalography


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Organ Transplantation;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Among the 12,000 individuals who serve as deceased organ donors yearly in the US, there are racial disparities that have persisted despite intervention, with the Black population most recently donating at 69% of the White population. Structural racism, the normalization and legalization of routinely disadvantaging minority populations, is an upstream social determinant of racial disparities in health and health outcomes, yet its contributions to racial and geographic variation in deceased organ donation have not been explored. The goal of this proposed research project is to examine whether structural racism and its downstream effects on healthcare resource availability and access explain racial and geographic differences in deceased organ donation; our results will be immediately applicable to contemporary policy addressing organ donor pool expansion and governing the allocation of scarce deceased donor organs.

PI_NAMEs: BROWN, LAWRENCE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;Affect;Benchmarking;Big Data;Black Populations;Cause of Death;certificate program;Cessation of life;Characteristics;Clinical;clinical investigation;County;Data;Data Linkages;data management;Data Set;Databases;density;deprivation;Disadvantaged minority;Doctor of Philosophy;Educational Status;Enrollment;Face;Faculty;Frequencies;geographic difference;geographic disparity;Geography;Goals;Health;health care availability;Health care facility;health care service utilization;Health Disparities Research;health disparity;health inequalities;Health Policy;Healthcare;Home;Hospitalization;Hospitals;improved;Individual;Inpatients;Instruction;International;Intervention;Knowledge;Legal;Location;Long-Term Care;Mediating;Mediator;Medical;Mentors;Mentorship;Methods;Midwestern United States;Minority;Minority Groups;mortality;multilevel analysis;National Health and Nutrition Examination Survey;Neighborhoods;novel;Operative Surgical Procedures;Organ;organ allocation;Organ Donations;Organ Donor;Organ Transplantation;Outcome;Outpatients;Policies;Population;programs;Proxy;Public Health;Public Health Schools;Race;racial determinant;racial difference;racial disparity;racial health disparity;racial minority;Racial Segregation;racism;Recovery;Registries;Research;Research Project Grants;residential segregation;Resources;Risk Factors;rurality;Scientist;segregation;skills;social determinants;social epidemiology;Source;Statistical Computing;statistical learning;Statistical Models;Structural Racism;Surgeon;Time;Training;Transplant Recipients;transplant registry;Transplantation;Urbanicity;Wait Time;Waiting Lists;Work

PROJECT_TITLE: The Effect Of Structural Racism On Racial And Geographic Disparities In Deceased Organ Donation


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE The development of vaccination strategies that protect against both known and future COVID-19 variants would greatly impact the COVID-19 pandemic trajectory and long-term global public health. This project will help determine which combination of diverse sarbecovirus exposures leads to the development of pan- sarbecovirus neutralizing antibodies, by conducting longitudinal surveillance of human cohorts naturally exposed to a high diversity of sarbecoviruses in Myanmar. Our findings will have broad implications for vaccine development and understanding of high-risk behaviors that are contributing to sarbecovirus spillover in a critically important ecological region for coronavirus emergence.

PI_NAMEs: EVANS, TIERRA SMILEY (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Age;Antibody Response;Behavior;Behavioral;Binding;Biological;Biological Assay;biological specimen archives;Characteristics;Chiroptera;cohort;Communities;Coupled;COVID-19 pandemic effects;Data;Deforestation;Development;Effectiveness;Elephants;exposed human population;Exposure to;forest;Frequencies;Funding;Future;Harvest;high risk;high risk behavior;Human;Immune response;Immunization Programs;Individual;Infection;Investigation;Medical History;Myanmar;neutralizing antibody;novel;novel coronavirus;Pattern;Phenotype;Population;post SARS-CoV-2 infection;pre-pandemic;Process;prospective;Public Health;Religion;Risk Behaviors;Risk Factors;Sampling;Sarbecovirus;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 infection history;SARS-CoV-2 variant;Serum;Specimen;Surveys;System;Time;United States National Institutes of Health;USAID;Vaccination;vaccination strategy;vaccine development;vaccine strategy;Vaccines;variants of concern;Viral;Virus;virus genetics;Waxes;Work;Zoonoses

PROJECT_TITLE: Investigation of sarbecovirus exposure patterns and development of pan-SARS-CoV-2 neutralizing antibody responses in high-risk cohorts in Myanmar

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE This project is relevant to public health because neutrophilic asthma is associated with poor response to existing therapies and increased disease severity. Understanding the biologic mechanisms responsible for severe asthma exacerbations, specifically the role of microRNAs in neutrophilic airway inflammation, will lead to the identification of new treatment modalities. This project will ultimately improve outcomes in severe neutrophilic asthma through tailored therapeutic development.

PI_NAMEs: GOMEZ-VILLALOBOS, JOSE LUIS (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Airway Disease;airway epithelium;airway inflammation;airway obstruction;Asthma;asthma exacerbation;Binding;Biological;Biological Products;Cell Separation;Cells;cohort;Data Set;Environment;Epithelial Cells;experimental study;extracellular;extracellular vesicles;Foundations;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Hospitalization;IL17 gene;improved;improved outcome;In Situ Hybridization;Inflammation;Inflammatory;Inhalation;Knowledge;Lymphocyte;member;Messenger RNA;MicroRNAs;miRNA expression profiling;Modality;neutrophil;New York;novel;Pathway interactions;Patients;Public Health;Quality of life;Registries;Regulation;response;Role;Sampling;Severities;Severity of illness;Sputum;Steroid Resistance;Systems Biology;Therapeutic;therapeutic development;therapeutic target;Toll-Like Receptor Pathway;transcriptome sequencing;Transfection;treatment response;Universities;Untranslated RNA;Work

PROJECT_TITLE: Systems Biology of a MicroRNA Network in Neutrophilic Asthma

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

PHR: PROJECT NARRATIVE A third major spillover of a novel coronavirus from its animal reservoir into a human population occurred in late 2019 setting off a pandemic of severe acute respiratory distress, viral pneumonia and death that continues to be a major public health threat to this day. In addition to safe and effective vaccines, direct-acting antivirals with complementary mechanisms of action and patterns of resistance are desperately needed to treat symptomatic individuals during the acute phase of SARS-CoV-2 infection. Here, we propose a medicinal chemistry plan and screening strategy to improve the potency and pharmacokinetic properties of a novel series of coronavirus inhibitors. Our goal is to identify a broadly active Development Candidate for the treatment of COVID-19 and other coronaviruses with pandemic potential.

PI_NAMEs: COBURN, GLEN  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;acute COVID-19;Acute Respiratory Distress Syndrome;Address;Ames Assay;Animals;antagonist;Anti-viral Agents;Biological;Biological Availability;Caco-2 Cells;candidate selection;Canis familiaris;Case Fatality Rates;Cell Culture System;Cell Line;Cessation of life;Chemicals;Clinical;Complement;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 treatment;cytotoxic;Development;Dose;Drug Design;drug discovery;Drug Evaluation;Drug Interactions;Drug Kinetics;drug repurposing;Epidemic;experience;Exposure to;Future;future outbreak;genotoxicity;global health;Goals;Healthcare Systems;Hepatocyte;high throughput screening;Human;human coronavirus;improved;In Vitro;in vivo;Individual;Infection;inhibitor;Intervention;Intestines;Lead;lead optimization;Maximum Tolerated Dose;meter;Microsomes;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular Target;Mus;Mutagenicity Tests;nirmatrelvir;novel;novel coronavirus;Oral;pandemic coronavirus;pandemic disease;pandemic potential;patient population;patient subsets;Patients;Pattern;Paxlovid;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology Study;Phase;pill;Plasma;Population;Positioning Attribute;Predisposition;Prevention;Property;Protein Isoforms;Public Health;Publishing;Rattus;Resistance;Resistance profile;respiratory;Respiratory Disease;Risk;Safety;safety study;SARS coronavirus;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;scale up;screening;Series;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;Solubility;spillover event;Stress;Symptoms;technique development;Therapeutic;Toxic effect;Toxicology;Vaccines;Variant;Viral;Viral Physiology;Viral Pneumonia;Virus;World Health;zoonotic coronavirus

PROJECT_TITLE: Optimization of orally bioavailable inhibitors for the treatment of COVID-19 and other human coronavirus infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]