NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Human cytomegalovirus (HCMV) causes life threatening illness in the immunocompromised and congenital disabilities in newborns. The proposed research is important to public health since defining the mechanisms underlying HCMV remodeling of host metabolism and identifying unique lipid signatures of infection will allow us to better understand virus replication. The research will develop fundamental knowledge of HCMV biology that will identify viral and host factors necessary for virus replication.

PI_NAMEs: PURDY, JOHN GERARD (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Binding;Biochemical Pathway;Biological;biological adaptation to stress;Biological Process;Biology;Cells;Cessation of life;CRISPR/Cas technology;Cytomegalovirus;Cytomegalovirus Infections;Data;Dietary Intervention;disability;Disease;Ensure;Environment;Enzymes;experience;Foundations;FRAP1 gene;Glycoproteins;Goals;Herpesviridae;Human;Immunocompromised Host;Infection;Integration Host Factors;Knock-out;Knowledge;Lecithin;Life;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Lipids;Membrane;Metabolic;Metabolism;Modeling;Molecular;mutant;Newborn Infant;novel;Phospholipids;Positioning Attribute;programs;Proteins;Public Health;receptor;Research;response;Role;Signal Pathway;Signal Transduction;small molecule;Stress;Tail;Testing;Very Long Chain Fatty Acid;Viral;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Mechanisms of Human Cytomegalovirus Reprogramming of Lipid Metabolism

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: GLASSBORO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE N-lysine acetylation is an important regulatory post-translational modification found not only on eukaryotic proteins, but also on hundreds of bacterial proteins involved in a broad array of essential biological processes. We will explore the functional significance of the acetylation of the histone-like protein HBsu, which may reveal the existence of a bacterial histone-like code. A mechanistic understanding of how protein acetylation influences HBsu function in chromosomal organization during various DNA transactions is critical to our understanding of bacterial physiology, and the proposed work with the model bacterium Bacillus subtilis may ultimately provide the foundation for designing novel antimicrobial drugs.

PI_NAMEs: CARABETTA, VALERIE JEAN (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Affect;anti-microbial drug;antimicrobial;Bacillus subtilis;Bacteria;Bacterial Physiology;Bacterial Proteins;Biochemical;Biological Process;Biology;Cell division;Cell Physiology;Chromosome Structures;Chromosomes;Code;Deacetylation;design;Development;DNA;Drug Targeting;Drug Tolerance;Enzymes;Eukaryota;Foundations;Gene Expression;Genetic Recombination;Goals;Histone Acetylation;Histone Code;Histones;inhibitor;Investigation;Knowledge;Lysine;Mass Spectrum Analysis;member;Modeling;Modification;N-terminal;novel;Phase;Physiological;Post-Translational Protein Processing;Process;programs;Protein Acetylation;Protein Family;Proteins;Proteomics;Regulation;repaired;Research;Site;Tail;Techniques;Work

PROJECT_TITLE: Investigation of  the physiological significance of protein acetylation in Bacillus subtilis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: The long-term goal of the University of Chicago Neuroscience Early Stage Scientist Training Program (NESSTP) is to diversify the Neuroscience research workforce. The NESSTP provides exposure to research and training experiences in Neuroscience for undergraduate students from under-represented groups; career and professional development opportunities for underrepresented undergraduate, graduate, and postdoctoral fellows engaged in Neuroscience; and cross-level mentoring at each training stage.

PI_NAMEs: MASON, PEGGY ;SCHWARTZ, NANCY B (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: academic standard;Acclimatization;Area;Articulation;aspirate;Basic Science;career;Career Choice;Career Exploration;career networking;Chicago;college;Communities;Development;Discipline;Doctor of Philosophy;Educational Status;empowerment;Ensure;Environment;experience;Exposure to;Faculty;faculty mentor;Fostering;Foundations;Funding;Generations;Goals;graduate school;graduate school preparation;graduate student;Head Start Program;Institution;Institutionalization;interest;Intervention;Interview;Journals;Knowledge;Laboratories;Laboratory Research;Leadership;Learning;Literature;Medical;meetings;Mentors;Mentorship;Methods;Mission;Neurosciences;Neurosciences Research;peer coaching;Positioning Attribute;Postdoctoral Fellow;Prize;programs;Readiness;recruit;Research;Research Training;Resources;Rotation;Scientist;Secure;Self Efficacy;skill acquisition;skills;Societies;Students;success;Teacher Professional Development;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE A thorough understanding of longitudinal retinal ganglion cell (RGC) functional and metabolic changes is critical for timely detection and treatment of glaucoma, accurate assessment of its progression, and development and testing of targeted neuroprotective therapies. The proposed experiments will develop advanced, first-of-its-kind two-photon in vivo retinal imaging platform to determine dynamic functional and metabolic features of glaucomatous RGCs at both bulk and single-cell levels using our newly developed inducible and reversible ocular hypertension animal models. The experiments have the potential to discover previously unappreciated glaucoma signatures for detecting, monitoring, and evaluating the disease and its progression.

PI_NAMEs: HU, YANG  (contact);ZHANG, HAO F

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acute;Anatomy;Angle-Closure Glaucoma;Animal Model;Animals;Belief;Biological Markers;Biosensor;Blindness;Blood Vessels;calcium indicator;Cell Physiology;cell type;Cells;cellular imaging;Cessation of life;Characteristics;Chronic;clinically relevant;Color;Combined Modality Therapy;Contact Lenses;Cornea;Data;Dehydration;Detection;Development;Disease;Disease Progression;Electrophysiology (science);Evaluation;Excision;experimental study;Fluorescence;Functional disorder;Functional Imaging;Fundus photography;Glaucoma;Image;imaging modality;imaging platform;imaging system;Imaging Techniques;improved;in vivo;in vivo imaging;in vivo optical imaging;Individual;Interdisciplinary Study;Investigation;Label;Lasers;Light;Lighting;Metabolic;Metabolism;Modeling;Monitor;Morphology;Motion;Mus;Nerve Degeneration;neural circuit;Neural Retina;Neurons;neuroprotection;non-invasive imaging;novel;Ocular Hypertension;Open-Angle Glaucoma;Ophthalmology;Ophthalmoscopy;Optics;overexpression;Pattern;Phenotype;Photic Stimulation;Photons;Photoreceptors;Physiologic Intraocular Pressure;Physiology;Predisposition;prevent;Property;Protocols documentation;resilience;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;retinal stimulation;Scanning;sensor;Severities;Silicone Oils;Spottings;System;Testing;Time;Transgenic Mice;Traumatic injury;two-photon;Update;visual processing;visual stimulus;Visualization

PROJECT_TITLE: In Vivo Function and Metabolism Evaluation of Glaucomatous RGCs by Two-Photon Scanning Laser Ophthalmology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Recognition of microbial ad host inflammatory moieties leads to a profound reprograming of the metabolism of phagocytes. Here, we hypothesize that endogenous oxidized phospholipids play crucial roles to rewire the metabolic state of macrophages and potentiate inflammation upon lipopolysaccharide encounter. We also hypothesize that the metabolism of these empowered immune cells can be harnessed against septic shock to develop novel and effective therapeutic interventions.

PI_NAMEs: ZANONI, IVAN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Affect;AKT inhibition;Anti-Inflammatory Agents;Bacteremia;Binding;Biochemistry;Cells;Cessation of life;Complex;conditional knockout;Country;cytokine;Data;Development;empowerment;Endotoxic Shock;Environment;enzyme activity;Epigenetic Process;epigenomics;Equilibrium;Extracellular Space;EZH2 gene;FDA approved;forging;Genes;Genetic Transcription;Goals;Gram-Negative Bacteria;Histone H3;histone methylation;Homeostasis;Human;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;in vivo evaluation;Inflammasome;Inflammation;Inflammatory;Injury;Innate Immune System;innovation;Interleukin-1 beta;Interleukin-10;Intervention;Knockout Mice;Ligands;Lipopolysaccharides;Lysine;Macrophage;Mediating;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Methionine;microbial;Mitochondria;Modification;Molecular;mouse model;Mus;novel;novel therapeutic intervention;oxidation;oxidized phosphatidyl choline;pathogen;Pathology;Pattern;Pattern Recognition;Pattern recognition receptor;Phagocytes;Pharmaceutical Preparations;Phase;Phospholipids;Phosphorylcholine;Play;polymicrobial sepsis;prevent;Process;Production;Proto-Oncogene Proteins c-akt;Recovery;Role;Sepsis;Septic Shock;Signal Transduction;Site;Solid;Sterility;Syndrome;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;tissue injury;Transgenic Organisms;Work

PROJECT_TITLE: Macrophage immunometabolism controls septic shock

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Transcription factors are proteins that control how and when genes are turned on or expressed. Proper control of gene expression is critical for normal cell function, and transcription factor disruption is frequently associated with human disease. We have taken a new approach to study transcription factors in which these proteins are rapidly degraded by a small molecule, and we will build upon these studies to define the mechanism of transcriptional control by these critical proteins.

PI_NAMEs: STENGEL, KRISTY  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;biological adaptation to stress;Biological Assay;Cell Physiology;Cells;chemical genetics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Cues;Detection;developmental disease;Disease;Enhancers;extracellular;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;genetic approach;Genetic Transcription;genome editing;genome-wide;Heterogeneity;Hour;human disease;imaging approach;knock-down;Malignant Neoplasms;Masks;Mediating;Mediator;Modeling;Nervous System Disorder;Normal Cell;novel strategies;programs;promoter;Proteins;Proteomics;response;single molecule;small molecule;transcription factor;Transcriptional Regulation

PROJECT_TITLE: CRISPR-mediated Chemical Genetics Define Transcription Factor Gene Networks and Mechanisms of Control

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Disability Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE At-home testing is an important part of mitigating the spread of COVID-19, but these tests are not accessible to people with low vision or blindness. Instead of adapting to a technology originally built for sighted people, we propose a no-power version that reports test results through a texture change, which people can feel by touch. This platform could be used not only for COVID, but also for other diagnostics, and will promote the independence and privacy for people with low vision or blindness by removing the need for human assistance or an internet connection.

PI_NAMEs: DHONG, CHARLES B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 2019-nCoV;Antibodies;antibody conjugate;antigen binding;Antigens;Auditory;Binding;blind;Blindness;chemical bond;Chemistry;Collaborations;Color;comparative;Computational Technique;Computer Models;Computer Simulation;Contrast Media;COVID-19;COVID-19 diagnostic;COVID-19 test;design;Detection;Devices;Diagnostic;Discrimination;Disease;Engineering;Ensure;Esterification;Event;Feedback;Film;Formulation;Friction;Glass;Gold Colloid;Home;home test;Human;Image;Immunoassay;Individual;interest;Internet;Lateral;Liquid substance;Mechanics;Methods;mobile application;Molecular;Molecular Computations;molecular dynamics;molecular scale;Monoclonal Antibodies;monolayer;Morphology;Outcome;particle;Patch Tests;Pattern;Persons;phase change;Phase Transition;Physiological;Polymers;Pregnancy Tests;Privacy;Proteins;prototype;PSSO3;Psychophysics;rapid testing;Reader;Reporting;response;Roentgen Rays;Saliva;saliva sample;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 negative;SARS-CoV-2 positive;Science;Self-Help Devices;Signal Transduction;Silanes;Solid;Sorting;Structure;success;Surface;surface coating;Tactile;Technology;Test Result;Testing;Texture;Thinness;tool;Touch sensation;Training;United States National Institutes of Health;usability;Variant;Vision;Visual;Visual impairment;Visually Impaired Persons;Water

PROJECT_TITLE: No power, at home COVID diagnostic with tactile readout

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Patients with treated HIV infection develop chronic disorders of their fat tissues and liver that lead to diabetes, heart disease and liver failure. These disorders are also associated with malfunctioning of a new hormone called FGF21 and related change of some of the body fat into an energy-wasting form of fat. The goal of this project is to determine what causes these two effects in a mouse model, and how they lead to the metabolic problems in patients with HIV infection.

PI_NAMEs: LAKE, JORDAN E (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: abdominal fat;Adipocytes;Adipose tissue;Affect;antiretroviral therapy;Blood;Body fat;Brown Fat;Chronic Disease;Clinical;comorbidity;Complex;Coupled;Data;Defect;Development;Diabetes Mellitus;Disease;Dissection;Dyslipidemias;Endocrine;energy balance;Energy Metabolism;Esterification;Exhibits;Expenditure;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;fatty liver disease;fibroblast growth factor 21;Functional disorder;Gene Deletion;Gene Expression Regulation;Glucose;glucose metabolism;Goals;Heart Diseases;Hepatic;HIV;HIV Infections;Hormones;Immunology;Impairment;improved;Indirect Calorimetry;Insulin Resistance;insulin sensitivity;insulin sensitizing drugs;Intra-abdominal;Kinetics;knockout gene;lifestyle intervention;Link;lipid metabolism;Lipids;Lipolysis;Liver;Liver Failure;liver metabolism;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;Molecular;mouse model;Mus;new therapeutic target;novel therapeutics;Patients;Persons;Pharmaceutical Preparations;Physiological;Physiology;Research;Serum;Shapes;Signal Transduction;subcutaneous;targeted treatment;Testing;therapeutic target;Thermogenesis;Tissues;transgene expression;Viral;Virus;vpr Gene Products;wasting;Work

PROJECT_TITLE: Metabolic impact of FGF-21 in adipose tissue and liver of PLWH


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Understanding and successfully treating disorders of the brain and nervous system is critically important due to the major impact of neurological and psychiatric disease on public health and the losses in productivity that result. This broadly based training program is designed to provide a solid foundation in neuroscience, from molecules to circuits and systems, in combination with a strong research training using the newest research tools and approaches to understand the complexities of the brain. The purpose of this renewal is to provide outstanding individualized training to talented predoctoral students who will devote their careers to address key challenges in both basic as well as translational neuroscience.

PI_NAMEs: ELIAS, CAROL FUZETI (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Early Stage Training in the Neurosciences


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The risk and severity of disease associated with environmental and endogenous exposures can vary greatly depending on the unique genetic makeup of an individual. The large number of possible genetic and environment combinations limits our ability to identify these interactions despite their potential to inform strategies for disease prevention and therapeutic intervention. I propose to develop high-throughput methods that overlay genetic and environmental perturbations to systematically identify these gene-by-environment interactions as well as pinpoint the specific cell types responsible for the response.

PI_NAMEs: MCFALINE-FIGUEROA, JOSE LUIS (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Alzheimer's Disease;cell type;Cells;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Couples;Disease;disorder prevention;Environment;Epilepsy;Exposure to;flexibility;gene environment interaction;Genes;Genetic;genetic makeup;Genetic Screening;Genetic Transcription;Goals;In Situ;In Vitro;in vivo;Individual;individual response;Malignant neoplasm of brain;Methods;Molecular;Mus;Mutate;Mutation;Neurobiology;Neurons;Nuclear;Oxidative Stress;Peptides;preventive intervention;programs;receptor expression;Research;Resolution;response;Risk;Sampling;Severity of illness;single cell genomics;single-cell RNA sequencing;System;Technology;Therapeutic Intervention;tool;tumor;Virus Receptors

PROJECT_TITLE: Defining gene-by-environment interactions using multiplex single-cell genomics


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Peripheral Neuropathy;Prevention;Rare Diseases;Rehabilitation;Urologic Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: The public health significance of this proposal resides in the fact that each year more than 5.8 million patients are diagnosed with a cancer for which first-line therapy can potentially include platinating agents; however, there are few means of identifying patients at risk for platinum-induced toxicities who might be offered alternative therapy, improved symptom management, or reduced-dose regimens. For patients who must receive platinum, there are no approved preventive measures and few treatments for toxicities. Our proposal is designed to fill these gaps.

PI_NAMEs: TRAVIS, LOIS B. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Accounting;Address;Adult;Age;Alternative Therapies;Blood Banks;Cancer Survivor;chemotherapy;Cisplatin;Classification;Clinical;Clinical Oncology;cohort;Collection;comorbidity;cost;Cytotoxic agent;Data;Data Collection;deafness;design;Development;Diagnosis;dosage;Dose;Emotional;evidence based guidelines;exome;exome sequencing;follow-up;Future;Genetic;genetic architecture;Genetic Markers;Genetic Predisposition to Disease;Genetic Variation;Genotype;Grant;Health;health related quality of life;Hearing Aids;hearing impairment;Hearing Tests;Heavy Drinking;high risk;Hypertension;Impact evaluation;Impairment;Intervention;Journals;Longterm Follow-up;Malignant neoplasm of testis;Malignant Neoplasms;Manuscripts;modifiable risk;Morbidity - disease rate;Neuropathy;ototoxicity;Outcome;Patients;Pharmaceutical Preparations;Physical Examination;Platinum;Platinum Compounds;Predisposition;Prevention strategy;Preventive measure;Productivity;psychosocial;Public Health;Publishing;Quality of life;Recommendation;Regimen;Residual state;Risk;Risk Factors;risk prediction model;Role;Serum;Severities;Smoking;social;Subgroup;Survival Rate;symptom management;symptomatic improvement;Testing;Time;Tinnitus;Tobacco use;Toxic effect;Treatment-related toxicity;WFS1 gene;young cancer survivor

PROJECT_TITLE: Genetic Susceptibility and Biomarkers of Platinum-related Toxicities

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This study will study a unique cohort including both people living with HIV and uninfected controls in Tanzania to determine whether central auditory tests could predict the subsequent development of cognitive programs or screen for cognitive problems in those with HIV. This could alter clinical practice if these easy-to-perform central auditory tests could be used clinically to screen for or track central nervous system effects in people living with HIV This study will also evaluate the long-term auditory effects of HIV infection and treatment.

PI_NAMEs: BUCKEY, JAY C (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Affect;Age;age acceleration;age effect;Aging;Anti-Retroviral Agents;antiretroviral therapy;Audiology;Auditory;auditory processing;Auditory system;Biometry;Brain;Central Nervous System;Clinical;clinical practice;Cognition;Cognitive;Cognitive deficits;cognitive performance;cognitive process;cognitive testing;cohort;Collaborations;comorbidity;comparison control;Complex;Data;detection test;Development;Digit structure;Education;Evaluation;experience;follow-up;Future;Goals;Hearing;Hearing Tests;HIV;HIV Infections;HIV/AIDS;Human Resources;Impaired cognition;Individual;innovation;interest;International;literacy;Longitudinal cohort;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;Machine Learning;Measures;Mission;National Institute on Deafness and Other Communication Disorders;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Noise;Otolaryngology;ototoxicity;Participant;Patients;Performance;performance tests;Peripheral;Persons;Pharmaceutical Preparations;Positioning Attribute;programs;Research;response;screening;Sensitivity and Specificity;sound;speech in noise;Tanzania;Techniques;Test Result;Testing;Time;Training;treatment response;United States National Institutes of Health;Work

PROJECT_TITLE: Advancing and applying peripheral and central auditory findings in HIV/AIDS.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Regenerative Medicine

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Technological advances in single cell RNA sequencing platforms have rapidly advanced our understanding of cellular heterogeneity within complex multicellular organ systems, however validating these data remain a major challenge. Ultrastructural electron microscopy is the gold standard for cell type identification by recognition of definitive physical features, however sample preparation and analysis are arduous and low- throughput. Our laboratory is combining these techniques with deep learning as a novel workflow to predict and confirm epithelial changes in pancreatic metaplasia to understand the processes and mechanisms underlying epithelial injury and regeneration.

PI_NAMEs: DELGIORNO, KATHLEEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Adult;Area;Atlases;biomarker identification;Body System;cell type;Cells;Characteristics;Complex;Data;Data Set;deep learning;Dehydration;Dimensions;disease model;Disease Progression;Duct (organ) structure;Electron Microscopy;epithelial injury;Epithelium;epithelium regeneration;experimental study;frontier;Gastroenterology;Gastrointestinal tract structure;genetic manipulation;Geometry;Goals;healing;Heterogeneity;Image;image processing;Immunofluorescence Immunologic;Individual;Inflammation;insight;Laboratories;light microscopy;Machine Learning;Maps;Mediating;Metaplasia;Mitochondria;Modeling;molecular marker;mouse model;multimodality;Natural regeneration;novel;Nuclear;Pancreas;Pancreatic Injury;pancreatic metaplasia;Phenotype;Physiological;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;programs;response;response to injury;Role;Sampling;Scanning Electron Microscopy;Secretory Cell;Sensory;sequencing platform;Shapes;single-cell RNA sequencing;spatial relationship;Techniques;Technology;tissue injury;tissue regeneration;Tissues;tool;transcriptome sequencing;tumorigenesis;Work

PROJECT_TITLE: A multi-modality approach to decode epithelial heterogeneity and function in metaplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The work of this application is based on evidence that hippocampal hyperactivity is involved in mediating psychosis and that a clear and understandable pattern of hippocampal tissue pathology exists to support neuronal overactivity in hippocampus. We are reproducing this tissue pathology in a mouse and then will test the animal to determine the characteristic cellular activity in CA3, the region which we have determined is critical to the generation of hippocampal hyperactivity in human psychosis. If successful, this outcome will provide a long-sought strong inference animal preparation important for psychosis understanding.

PI_NAMEs: TAMMINGA, CAROL A (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;age related;Amygdaloid structure;Anatomy;Animal Behavior;Animal Testing;Animals;Area;Attenuated;Autopsy;Back;Behavior;Behavioral;behavioral outcome;Brain;Brain Diseases;Brain imaging;Brain Pathology;brain tissue;Brain-Derived Neurotrophic Factor;Cell Culture Techniques;Characteristics;Cognitive;comparison control;critical period;dentate gyrus;designer receptors exclusively activated by designer drugs;Development;Disease;DLG4 gene;Electrophysiology (science);experimental study;Functional disorder;Gene Expression;Generations;Genetic;Glutamate Receptor;Goals;Golgi Apparatus;Hippocampus;Human;human tissue;Hyperactivity;Image Analysis;Knock-out;knockout animal;Knockout Mice;Medial;Mediating;Memory;Modeling;Molecular;molecular marker;molecular pathology;mossy fiber;Mus;Neurobiology;Neurons;NMDA receptor A1;Nucleus Accumbens;Outcome;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Prefrontal Cortex;Preparation;Proteins;Psychoses;psychotic;Pyramidal Cells;Reporting;Sampling;Schizophrenia;Signal Transduction;Site;Structure;Synapses;Techniques;Testing;Time;Tissues;transcriptome;Translations;transmission process;Work

PROJECT_TITLE: Reverse Translation of Psychosis - associated Hippocampal Hyperactivity in the mouse

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Many genetic variants have been associated with common complex diseases, but the evolutionary and functional architectures that shape genome-wide risk are still unclear. Recent efforts to characterize the extent to which natural selection and functional genomic features determine genetic risk have primarily targeted complex disease in European ancestry populations, which substantially limits the potential to understand disease etiology and stands to further health disparities. Here, we develop and apply novel scalable computational approaches characterize the evolutionary and functional architectures in multiple diverse populations and phenotypes to elucidate the mechanisms mediating risk for complex disease.

PI_NAMEs: MANCUSO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Address;Alleles;Architecture;Atlases;Awareness;Biological Assay;Catalogs;causal variant;Cells;Complex;Coupled;Data;direct application;Disease;disease phenotype;disorder risk;disparity reduction;Ethnic Origin;Etiology;European ancestry;Exhibits;experimental study;Frequencies;functional genomics;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Models;Genetic Risk;genetic variant;Genets;Genome;genome wide association study;genome-wide;Genomics;Geography;health disparity;Heritability;Heterogeneity;improved;Individual;Inherited;large scale data;Linkage Disequilibrium;Maps;Mediating;men;Messenger RNA;metabolic abnormality assessment;Methods;Modeling;Molecular;molecular modeling;molecular phenotype;molecular scale;molecular shape;multi-ethnic;Natural Selections;novel;novel strategies;open source;Pathway interactions;Performance;Peripheral;Phenotype;polygenic risk score;Population;Population Heterogeneity;population stratification;pressure;Procedures;Reduce health disparities;Reporter;Reproducibility;Research Personnel;Resolution;Risk;risk prediction;Role;Running;Sample Size;Shapes;Signal Transduction;statistics;Susceptibility Gene;Testing;trait;transcriptomics;Translating;Work

PROJECT_TITLE: Characterizing the evolutionary architecture of complex disease within and across diverse populations

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Genetics;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative This research proposal is relevant to human health as resistance to head and neck cancer treatment results in reduced patient survival. Herein, we propose a novel approach to make treatment more effective, using an available and relatively safe dietary supplement. Therefore, this research proposal supports the NIH mission to improve human health, and the treatment and outcomes of cancer patients and the NIDCR's mission to improve oral health.

PI_NAMEs: WICKER, CHRISTINA A (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: alternative treatment;Apoptotic;Award;Biological Assay;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;cancer type;Cancerous;career development;Cell Death;Cell Death Signaling Process;Cell Line;Cell Survival;Cells;Cisplatin;Clinical Trials;Clinical Trials Design;Comet Assay;Committee Members;craniofacial;cytokine;Data;Dental;dietary antioxidant;dietary supplements;disadvantaged background;DNA Damage;Down-Regulation;Drug Targeting;efficacy evaluation;Functional disorder;Future;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health;Hematology;Human;Immunology;improved;improved outcome;in vivo;in vivo evaluation;Induction of Apoptosis;innovation;insight;interest;Isothiocyanates;K-Series Research Career Programs;keratinocyte;Knowledge;Malignant Neoplasms;Mediating;Mentored Research Scientist Development Award;Mentors;Mentorship;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Dental and Craniofacial Research;Neoplasm Metastasis;neoplastic cell;Normal Cell;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;Oncology;Oral;Oral health;Organoids;Outcome;Oxidative Stress;Oxidative Stress Induction;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Phenethyl Isothiocyanate;Photons;Phytochemical;pre-clinical;preservation;pro-apoptotic protein;Proton Radiation;Protons;Radiation;radiation effect;Radiation Oncology;Radiation Protection;radiation resistance;radiation response;Radiation therapy;Radiobiology;radioprotected;Radiosensitization;Reactive Oxygen Species;Research;research and development;Research Personnel;Research Proposals;Resistance;Resources;response;side effect;Signal Pathway;standard of care;success;Testing;Therapeutic;therapy resistant;Training;Transcription Alteration;transcriptome sequencing;transcriptomics;treatment and outcome;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor growth;Ulcer;United States National Institutes of Health;Up-Regulation;Validation;Western Blotting

PROJECT_TITLE: Mentored Career Development Award: Isothiocyanates to Improve Response to Proton Radiotherapy

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR(01)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Age associated neoplastic transformation is the result of individual cells escaping tumor suppressive barriers during the lifetime of an organism. Successful efforts towards preventing cancer initiation during aging are dependent on understanding and enhancing the proliferative barriers that govern tumor suppressive barriers. This proposal focuses on the mechanisms that are in place to eliminate precancerous cells during replicative aging, suggesting that crosstalk between telomeres, mitochondria and the inflammation machinery is critical to protect an aging organism from cancer development.

PI_NAMEs: KARLSEDER, JAN  (contact);SHADEL, GERALD

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age related;Aging;aging related;Alternative Splicing;Anchorage-Independent Growth;anti-cancer;Autophagocytosis;Binding;Biological Markers;Biology;biomarker identification;Bypass;cancer cell;cancer initiation;cell age;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Nucleus;Cells;Characteristics;Chromosomal Breaks;chromosome fusion;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;cytokine;Cytoplasm;Cytoprotection;Data;Dependence;design;Development;DNA;DNA Damage;Exhibits;Functional disorder;Gene Expression Profiling;genome wide screen;Genomic Instability;hallmarks of aging;Human;Immune;Immune signaling;in vivo;Individual;Inflammation;Inflammatory;Innate Immune System;Interferons;Knock-out;Malignant Neoplasms;Mediating;Metabolism;Mitochondria;mitochondrial genome;Molecular;mortality;neoplastic;neoplastic cell;Neoplastic Cell Transformation;novel;novel strategies;Nuclear;Nucleic Acid Binding;Nucleic Acids;Organism;Outer Mitochondrial Membrane;Pathway interactions;Phenotype;Play;Premalignant Cell;prevent;Prevention;programs;Proliferating;Protein Isoforms;Proteins;response;Retinoblastoma Protein;RNA;RNA Sequences;RNA Splicing;Role;senescence;sensor;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stimulator of Interferon Genes;structural determinants;System;telomere;Telomere Shortening;Testing;TP53 gene;Transcript;transcriptome;tumor;Tumor Escape;Tumor Suppressor Proteins;Variant;Viral;viral detection;viral DNA;Z-DNA Binding Protein

PROJECT_TITLE: A nucleus-to-mitochondria nucleic acid-sensing pathway prevents bypass of age-associated proliferative boundaries

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative The HBNU Fogarty Global Health Training Program, a consortium of Harvard University, Boston University, Northwestern University and the University of New Mexico, proposes to continue to contribute to global health research capacity building and the use of research to improve the health outcomes related to priority health areas in low- and middle-income countries (LMICs) in partnership with 18 sites throughout Africa, Asia, and South America. The Program will recruit US and LMIC trainees to strengthen global health research networks and programs at academic institutions and ultimately help sustain global health research in the US and LMICs.

PI_NAMEs: FAWZI, WAFAIE W (contact);HAMER, DAVIDSON HOWES;HAWKINS, CLAUDIA A;PERKINS, DOUGLAS JAY

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Award;Biomedical Research;Boston;Cardiovascular Diseases;career;co-infection;Collaborations;Competence;Creativeness;Diabetes Mellitus;Discipline;Disease;E-learning;Education;Evaluation;experience;Fostering;Future Generations;global health;HIV/AIDS;Individual;Institution;Interdisciplinary Study;International;Investments;low and middle-income countries;Malignant Neoplasms;Maternal and Child Health;medical schools;member;Mental Health;Mentors;Morbidity - disease rate;mortality;New Mexico;next generation;nutrition;Output;Peer Review;Persons;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Public Health Schools;Publications;Qualifying;Readiness;recruit;Research;research and development;Research Design;Research Methodology;Research Project Grants;Research Support;Research Training;Scientist;Site;Students;symposium;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Partnership for Global Health Research Training Program(Renewal)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

PHR: PROJECT NARRATIVE Long-acting injectable buprenorphine is an evidence-based treatment for opioid use disorder (OUD) that has the potential to improve patient outcomes, but is underutilized and infrequently available in settings where buprenorphine treatment is offered. We will implement injectable buprenorphine in one primary care clinic and one "low-threshold" clinic (based in a syringe services program) to identify barriers and facilitators to implementation, develop and test successful implementation strategies, and examine gaps in care following implementation of injectable buprenorphine. These data will be used to develop generalizable implementation manuals that can be scaled widely in other primary care and low-threshold settings to increase access to evidence-based OUD treatment.

PI_NAMEs: JAKUBOWSKI, ANDREA U (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adherence;Adoption;Attitude;Buprenorphine;buprenorphine treatment;career development;Caring;Clinic;clinical infrastructure;Clinical Trials;Communities;Consolidated Framework for Implementation Research;Data;design;Development Plans;Drops;Electronic Health Record;evidence base;Evidence based treatment;experience;Familiarity;Focus Groups;follow-up;Formulation;Foundations;Future;Goals;Health;Health system;homeless shelters;illicit opioid;implementation determinants;implementation evaluation;implementation facilitators;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation study;improved;Injectable;interest;Intervention Studies;Interview;Knowledge;Lived experience;Manuals;Maps;marginalized population;medical specialties;medication compliance;Medicine;Mentors;Mentorship;Methadone;Methods;mortality;Needle-Exchange Programs;opioid use;opioid use disorder;Outcome;Patient-Focused Outcomes;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Pharmacy facility;Phase;Physicians;Positioning Attribute;post implementation;Primary Care;primary care clinic;primary care setting;Proctor framework;Provider;psychosocial;Qualitative Methods;Quality of life;Research;Research Personnel;Research Project Grants;Self Administration;standard of care;Testing;Training;Uncertainty;uptake;Work

PROJECT_TITLE: Examining injectable buprenorphine implementation strategies in low-threshold and primary care settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Public health depends on medical research, and most medical research uses animals. Veterinarians improve medical research in many ways, but there are too few veterinary researchers. Our program addresses this national need by producing highly trained veterinarian-researchers.

PI_NAMEs: BUCKMASTER, PAUL S. (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Comparative Medicine Biosciences Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PUBLIC HEALTH RELEVANCE Parents are clearly an important focus for obesity prevention interventions, yet children who attend childcare spend a large proportion of time outside of parent care and can consume half of their daily dietary intake in this setting. Also, children may receive different messages from these two channels. The proposed research will study the acceptability, feasibility and pilot test the efficacy of a multi- component intervention focusing on supporting and empowering parents through the assistance of family child care providers (including Spanish-speaking parents and providers) to improve the food and PA environments in their homes to improve the dietary, physical activity and sedentary behaviors of the children 18-54 months in their care.

PI_NAMEs: GANS, KIM M.;RISICA, PATRICIA MARKHAM (contact);TOVAR, ALISON

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Attention;Behavior;Beverages;Body mass index;Cardiometabolic Disease;Cardiovascular Diseases;care providers;Caring;Carotenoids;Cessation of life;Child;Child Behavior;Child Care;Chronic;Clinical Trials;Cluster randomized trial;comparison intervention;Consumption;cost;Cues;Data;Dermal;Diabetes Mellitus;Diet;dietary;Dietary Fiber;Dietary intake;Dietary Intervention;Dietary Practices;Disease;Eating;Eating Behavior;effective intervention;efficacy testing;empowerment;Enrollment;Environment;ethnic diversity;ethnic minority;ethnic minority population;Extended Family;Family;Family member;feasibility research;feasibility testing;flexibility;follow-up;Food;food environment;Food Preferences;Foundations;frontier;Fruit;Future;Health;Heart;high risk;Home;Home environment;improved;innovation;Intervention;intervention refinement;Interview;Latinx;Licensing;Low income;minority children;Mission;Morbidity - disease rate;multi-component intervention;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nursery Schools;nutrition;Nutritional Study;Obesity;obesity prevention;obesity risk;Outcome;Parents;patient home care;Physical activity;pilot test;pilot trial;Preschool Child;Prevention;preventive intervention;primary outcome;Printing;Protocols documentation;Provider;public health relevance;Randomized, Controlled Trials;Research;response;Risk Factors;secondary outcome;sedentary lifestyle;Shapes;smartphone application;social;Spanish;Spanish/English;Suggestion;Time;Training;trend;Trust;Vegetables;Weight

PROJECT_TITLE: Healthy Start: An innovative, multi-level intervention with family child care providers and families to improve the dietary behaviors of preschool children

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research will provide a foundation for understanding how cell fate decisions are controlled within an epithelial stem cell lineage. Epithelial stem cells are central to both normal homeostasis and the progression of diseases such as cancer, so understanding how they are regulated their native, in vivo contexts is important for the development of new diagnostics and therapeutics. The proposed project will also contribute to the NIH mission to foster fundamental creative discoveries by investigating new and poorly understood topics such as stem cell niche competition and the role of pH dynamics in cell fate decisions.

PI_NAMEs: NYSTUL, TODD  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Affect;Aging;Alleles;Area;Atlases;beta catenin;Biological Models;cell behavior;Cell Differentiation process;Cell Lineage;cell type;Cells;Creativeness;daughter cell;Development;Disease;Disease Progression;Drosophila genus;epithelial stem cell;Epithelium;flexibility;Fostering;Foundations;Gene Expression Profile;Genetic;Homeostasis;in vivo;insight;interest;intestinal epithelium;Intestines;Ligands;Link;Malignant Neoplasms;mathematical model;Mission;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Normal tissue morphology;novel;novel diagnostics;novel therapeutics;Ovary;Physiological;Population Dynamics;Positioning Attribute;Post-Translational Protein Processing;Process;Property;Proteins;Protons;quantitative imaging;Research;Resolution;Role;segregation;self-renewal;sensor;Source;stem cell niche;stem cells;Stress;Structure;System;Tissues;tool;United States National Institutes of Health

PROJECT_TITLE: Cell Fate Decisions in Epithelial Stem Cell Lineages


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Nutrition;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: BIOLOGY

ORG_NAME: CLEVELAND STATE UNIVERSITY

PHR: Project Narrative. This project investigates connection between circadian clocks and mTOR signaling rhythms in calorie restriction. The circadian clock, mTOR pathway and calorie restriction are major regulators of metabolism and aging. The obtained data will help to develop a strategy for the treatment and prevention of age-associated diseases.

PI_NAMEs: KONDRATOV, ROMAN V (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acute;Address;Affect;age-related disease;Aging;Amino Acids;Animals;ARNTL gene;Behavior;Behavioral;Blood;Caloric Restriction;Calories;cardiometabolism;circadian;circadian pacemaker;Circadian Rhythms;Complex;Data;detection of nutrient;Diabetes Mellitus;Diet;Dietary Intervention;dietary restriction;Disease;Energy Intake;Equilibrium;experimental study;extracellular;Fasting;feeding;Food;FRAP1 gene;Gene Expression;Genes;Glucose;Growth Factor;Health;Hour;improved;in vivo;Incidence;Insulin;Intake;Longevity;Malignant Neoplasms;Mammals;Metabolic;Metabolism;Modeling;Molecular;mTOR Signaling Pathway;Mus;Mutant Strains Mice;Nutrient;Organism;Pathway interactions;Periodicals;Phosphotransferases;Physiological;Physiology;Play;prevent;Prevention;programs;public health relevance;Publishing;Regulation;response;Role;Signal Transduction;System;Testing;Tissues;transcriptional reprogramming;treatment strategy;TSC1 gene;TSC1/2 gene

PROJECT_TITLE: Circadian Clock and Dietary Restriction

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hydrocephalus;Lymphatic Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

PHR: Surgical treatment for post-hemorrhagic hydrocephalus (PHH) of premature infants is limited by our understanding of cerebrospinal fluid (CSF) production and circulation. In this pilot project, we will conduct transcranial, tomographic fluorescence imaging of CSF-indocyanine green (ICG) ventricular dynamics; assess CSF-ICG outflow into the peripheral lymphatics; and measure CSF biomarkers of inflammation in order to understand treatment responses of infants with PHH during standard-of-care treatments of conservative CSF diversion, endoscopic third ventriculostomy and choroid plexus coagulation.

PI_NAMEs: SEVICK, EVA M. (contact);SHAH, MANISH NARENDRA;ZHU, BANGHE

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Affect;Age;Arachnoid mater;Biological Markers;Biomedical Engineering;Birth Rate;Blood;Brain;Brain Injuries;Caring;Cephalic;Cerebrospinal Fluid;cerebrospinal fluid clearance;cerebrospinal fluid flow;Cessation of life;Child;Childhood;Choroid Plexus Epithelium;Circulation;Clinical Research;Clinical Trials Data Monitoring Committees;Coagulation Process;Creation of ventriculo-peritoneal shunt;Development;Developmental Disabilities;Diagnosis;Diffuse;disability;Doctor of Philosophy;draining lymph node;Economically Deprived Population;Engineering;Ensure;Etiology;experience;Failure;Fluorescence;fluorescence imaging;Fourth ventricle structure;Functional disorder;Future;Generations;healthcare burden;Hemorrhage;Hydrocephalus;Image;imaging detection;Impairment;improved;Indocyanine Green;Infant;Inflammation;Institutional Review Boards;Intracranial Hypertension;Intraventricular;intraventricular hemorrhage;Investigation;lateral ventricle;Lymph;Lymphatic;lymphatic imaging;Macaca fascicularis;Measurement;Measures;Mediating;Minimal Risk Study;Modeling;Neonatal;neuroinflammation;Neurosurgeon;novel;Operative Surgical Procedures;Optical Tomography;Optics;Outcome;patient population;Peripheral;Pilot Projects;Play;Plumbing;point of care;pre-clinical;preclinical study;Premature Birth;Premature Infant;prenatal;prevent;Prevention;Production;Prognosis;Research;Rodent;Role;Second Look Surgery;socioeconomic disadvantage;Spinal Cord;standard of care;Structure of choroid plexus;Subarachnoid Space;System;Techniques;temporal measurement;therapeutic target;Third ventricle structure;Time;tomography;tool;Translating;Translations;Treatment Failure;Treatment outcome;treatment response;treatment strategy;Ventricular;Ventriculostomy;wasting

PROJECT_TITLE: Assessing CSF flow dynamics in pediatric hemorrhagic hydrocephalus

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: UPR COBRE Center for Neuroplasticity During Phase 3 the UPR Center for Neuroplasticity will continue to provide a multidisciplinary cadre of investigators with cutting-edge facilities, scientific capability, and multidisciplinary collaborations for the treatment of neurodegeneration-related diseases. Our projects are unified by shared thematic and technical factors toward understanding and treating neurological disorders, including, the origins of neural and mental health disorders, as well as elucidating the molecular basis for alcohol neuroadaptation, addiction, and neuroprotection. Our center will become a world-recognized center for the study of neurodegeneration-related diseases with therapeutic applications.

PI_NAMEs: LASALDE-DOMINICCI, JOSE ANTONIO (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: addiction;Advisory Committees;Alcohols;Anatomy;Animals;Applications Grants;Area;Award;Basic Science;Benchmarking;Biology;Biomedical Research;biomedical resource;Businesses;career;Centers of Research Excellence;Chemistry;Clinical Research;Collaborations;Communities;Contract Services;Core Facility;Cyclic GMP;design and construction;Development;Disease;Educational workshop;Electrophysiology (science);Ensure;Entrepreneurship;experience;Faculty;Familiarity;Fees;Floor;Fluorescence;Fostering;Funding;Goals;Grant;IACUC;Image;Industry;industry partner;innovation;Institution;instrument;instrumentation;Interdisciplinary Study;Investigation;Investments;Leadership;Medical;medical schools;member;Mental disorders;Mentors;Mentorship;Microscope;Microscopy;Molecular;multidisciplinary;multiphoton microscopy;Nerve Degeneration;Nervous System Disorder;neural;neuroadaptation;Neurobiology;neuroimaging;Neuronal Plasticity;neuroprotection;Neurosciences;Participant;patch clamp;Pharmacology;Pharmacy facility;Phase;Physiology;Pilot Projects;pre-clinical research;preclinical study;Principal Investigator;Privatization;Productivity;programs;Puerto Rico;Qualifying;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;Services;Slide;Source;square foot;synergism;Therapeutic;Training;translational applications;United States National Institutes of Health;Universities

PROJECT_TITLE: COBRE PHASE III:  Center for Neuroplasticity at the University of Puerto Rico


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: Project Narrative – Administrative Core The Administrative Core of the University of Puerto Rico COBRE Center for Neuroplasticity Phase 3 will support all scientific, faculty mentoring, and institutional development objectives of this program. Executive and fiscal program management will be carried out by a team of personnel with a proven track record in the operation and management of large multi-faceted research programs. The Administrative core will serve as the liaison with the program’s evaluation module and with the External and Internal Advisory Committees.

PI_NAMEs: MILLER, MARK W (contact)

PROJECT_TERMS: Acceleration;Administrator;Advisory Committees;Area;Award;Biomedical Research;Businesses;career;career development;Caribbean region;Cell Nucleus;Centers of Research Excellence;Collaborations;Communication;Communities;Core Facility;Data;Dedications;design;Development;Educational workshop;Electrophysiology (science);Evaluation;experience;Faculty;faculty mentor;Faculty Recruitment;Fostering;Funding;Future;Grant;Human Resources;Image;Individual;industry partner;Institution;instrumentation;Interdisciplinary Study;Island;Laboratories;Latin America;Leadership;Manuscripts;Medical;meetings;Mentors;Minority-Serving Institution;Molecular;National Institute of General Medical Sciences;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuroimaging;Neuronal Plasticity;Neurosciences;Neurosciences Research;operation;outreach;Phase;Pilot Projects;Play;Postdoctoral Fellow;Preparation;Program Evaluation;programs;Progress Reports;Puerto Rico;Records;recruit;Reporting;Research;Research Infrastructure;Research Personnel;residence;Resources;Science;Series;Students;symposium;Techniques;Therapeutic;Training Programs;Universities;Videoconferencing;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Merit and Health Relevance 3'-derived tRNA fragments are highly expressed in stem and cancer cells undergoing epigenetic reprogramming and target endogenous long terminal repeat (LTR)-retroviruses that become active during reprogramming in development and disease. Our overarching goal is to characterize and identify cellular proteins that mediate this novel small RNA silencing mechanism. The proposed research will advance our understanding of endogenous retrovirus control in mammals and the evolutionary role of tRNAs in RNA interference and genome stability, as well as be applicable to LTR-retroviruses that threaten human health such as HIV, RNA tumor viruses, and endogenous LTR-retroelements that drive oncogene expression in cancer.

PI_NAMEs: SCHORN, ANDREA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: arms race;Binding;Binding Proteins;Binding Sites;Biogenesis;Biological;Biological Assay;Biological Process;blastocyst;cancer cell;Candidate Disease Gene;candidate identification;Cell Culture Techniques;Cell Line;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complement;Data;Development;Developmental Gene;Diagnostic;Disease;DNA;Elements;embryo culture;Endogenous Retroviruses;endonuclease;Enzymes;Epigenetic Process;Eukaryota;Family;Gene Expression;Gene Silencing;Genetic Transcription;Genome;Genome Stability;genome-wide;Germ Lines;Goals;Hand;Health;Histone H3;HIV;Host Defense;Human;Human Cell Line;implantation;in vivo;in vivo evaluation;Injections;innovation;knock-down;Knock-out;knockout gene;Length;Link;Long Terminal Repeats;loss of function;Luciferases;luminescence;Lysine;Malignant Neoplasms;Mammals;Mediating;Methylation;Mobile Genetic Elements;Mus;mutant;Mutate;novel;Oncogenes;Oncornaviruses;piRNA;pluripotency;posttranscriptional;Predisposition;Process;Production;protein function;Proteins;Regulation;Reporter;Repression;Research;Retroelements;Retrotransposition;Retroviridae;Reverse Transcription;RNA;RNA Interference;RNA Interference Pathway;RNA Polymerase III;RNA-Binding Proteins;Role;screening;Shapes;Small RNA;Stem cell pluripotency;stem cells;Structure;Supporting Cell;Testing;Time;Tissues;Transfer RNA;Translations;Untranslated RNA;Work

PROJECT_TITLE: tRNA-fragments in transposon control

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Autism;Biotechnology;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE The structural birth defect of brain dysmyelination causes slowed and asynchronous signal transmission which can lead to seizures, attention deficit, autism and/or age–related cognitive decline. Dysmyelination is a consistent feature of people with an approximately 1.6 megabase deletion of chromosome 18q23. We are creating a team of clinical and basic scientists to evaluate the contribution of genes in this critical region, individually and in combination, to define their effect on myelinogenesis in mouse cells and patient-derived cell models in order to guide potential treatment development.

PI_NAMEs: CODY, JANNINE DE MARS (contact);HIROI, NOBORU ;LEHMAN, DONNA M

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 18q;Address;age acceleration;Age-associated memory impairment;Attentional deficit;autism spectrum disorder;Basic Science;Brain;brain cell;Cell Line;Cell model;Cell Physiology;Cells;Cellular Neurobiology;Characteristics;Chromosome 18;Chromosome Deletion;Chromosomes;Clinical;clinical investigation;Clinical Investigator;Clinical Research;clinical trial readiness;cohort;Collaborations;Conduct Clinical Trials;Cultured Cells;Data;data communication;data sharing;data submission;Defect;Development;Developmental Process;DNA;Dose;Drug Screening;Drug toxicity;Drug usage;dysmyelination;Effectiveness;Evaluation;experimental study;Failure;Fibroblasts;Future;gene product;Genes;Genetic;genetic information;Genetic Models;Genomic Segment;Genomics;Goals;Growth;Heterozygote;high throughput screening;Human;Human Chromosomes;human model;improved;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Intellectual functioning disability;Interdisciplinary Study;Link;lymphoblastoid cell line;member;Mental Depression;Modeling;Molecular;Morphogenesis;Morphology;mosaic;mouse model;Mus;Mutation;Myelin;myelination;neural;Neural Conduction;Neuronal Plasticity;neurotransmission;Oligodendroglia;Patients;Penetrance;Persons;Phenotype;phenotypic data;Positioning Attribute;processing speed;Production;programs;Proliferating;response;Role;Schizophrenia;Scientist;screening;Seizures;Signal Transduction;Small Interfering RNA;spheroids;Structural Congenital Anomalies;Structural defect;System;Testing;Therapeutic;therapy development;Time;Tissues;tool;translational potential;transmission process;Work

PROJECT_TITLE: Molecular and Cellular Mechanisms of Chromosome 18q23 Dysmyelination

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: Project Narrative: The Neuroimaging and Electrophysiology Facility (NIEF) is a core with state-of-the-art instruments and experienced technical staff to support, guide and advice the scientific community in Puerto Rico. The main goal of this proposal is to maintain the NIEF services in microscopy or electrophysiological strategies and continue the positive impact of our investigators in terms of publications, grants submissions, grants funded, patents obtained and students who have completed their degrees by using the facilities. Excellent services and instruments in the NIEF at the Molecular Science Research Center and the Institute of Neurobiology, maximizes the impact of our cores to help a variety of investigators in the island and support the well-planned sustainability of the cores beyond COBRE-3.

PI_NAMEs: MIRANDA, JORGE DAVID (contact)

PROJECT_TERMS: Academia;Academic degree;Anesthesia procedures;Animals;Applications Grants;Area;Biological;Biophysics;Brain;Calcium;Caribbean region;Cells;Centers of Research Excellence;Collaborations;Communities;Computer software;Core Facility;Cultured Cells;Data;data acquisition;Data Analyses;Development;Educational workshop;Electrophysiology (science);environmental enrichment for laboratory animals;Equipment;experience;experimental study;Faculty;faculty support;Fee-for-Service Plans;Fluorescence Microscopy;Funding;Generations;Goals;graduate student;Grant;Human Resources;Image;Industry;innovation;Institution;instrument;instrumentation;interest;investigator training;Island;Laboratories;Legal patent;Manuscripts;Microscope;Microscopy;Mission;Molecular;Monitor;Neurobiology;neuroimaging;Neuronal Plasticity;new technology;Oocytes;Outcome;Participant;Peer Review;Phase;Postdoctoral Fellow;Privatization;Procedures;Productivity;Publications;Publishing;Puerto Rico;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;role model;Scanning;Science;Scientist;service providers;Services;Slice;Students;Techniques;Technology;tool;Training;two-photon;ultra high resolution;undergraduate student;Universities;Visit;voltage


NIH_SPENDING_CATS: Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative This institutional training grant supports the University of South Carolina Behavioral-Biomedical Interface Program, which helps to prepare future behavioral scientists to be better equipped to address the complex challenges inherent in health research. Pre-doctoral trainees in public health and psychology acquire important biological and biomedical foundations in concert with their behavioral science disciplinary training. This program adds scientists to the workforce who are able to more effectively translate research into understanding, preventing, and treating health disorders of major societal import.

PI_NAMEs: BEETS, MICHAEL W;PRINZ, RONALD J (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Behavioral;Prevention;Science;Training

PROJECT_TITLE: Behavioral-Biomedical Interface: Translational and Prevention Sciences Training

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE As the US population ages, Alzheimer's disease) and its related dementias (ADRD) are responsible for ever- increasing morbidity, mortality, and health care costs. Unfortunately, little research has examined factors relevant to ADRD in non-white individuals. Using data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, made up of 6 large and long-term NIH-funded cohorts with racially diverse participants, we will build new ethnically diverse machine learning models, derive novel neuroimaging machine learning-based brain signatures of ADRD from them, and evaluate their clinical relevance across diverse ethnoracial groups. iii

PI_NAMEs: HABES, MOHAMAD  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Address;Adult;advanced analytics;Affect;Age;Aging;aging brain;aging demography;aging population;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;analytical method;Atherosclerosis Risk in Communities;Atrophic;Attenuated;Biological;Biological Markers;biomarker validation;Black American;Black Populations;Blood;blood-based biomarker;Brain;brain based;Brain imaging;cardiovascular health;cardiovascular risk factor;Caring;Cerebrovascular Trauma;CHI3L1 gene;Clinical;clinical diagnosis;clinically relevant;Cognition;cognitive function;cohort;Cohort Studies;Communities;comorbidity;Computer software;Data;Data Set;Dementia;dementia burden;dementia risk;Development;Diabetes Mellitus;Dimensions;Disease;disorder risk;Disparity;Dyslipidemias;ethnic difference;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;ethnoracial;Exposure to;Framingham Heart Study;functional decline;Functional Magnetic Resonance Imaging;Funding;Future;Genetic;genomic epidemiology;Glial Fibrillary Acidic Protein;Health Care Costs;health disparity;Heart;Heterogeneity;high dimensionality;Hispanic Americans;Hispanic Populations;Hypertension;Impaired cognition;Incidence;Individual;Insulin Resistance;Intervention;Intervention Trial;Knowledge;life span;lifestyle data;Light;Longitudinal cohort;Machine Learning;machine learning algorithm;machine learning method;machine learning model;machine learning prediction;Magnetic Resonance Imaging;Medical;Metabolic syndrome;Microvascular Dysfunction;mild cognitive impairment;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multimodal neuroimaging;Neuroanatomy;Neurodegenerative Disorders;neurofilament;neuroimaging;neuroimaging marker;Not Hispanic or Latino;novel;Obesity;Onset of illness;Participant;Pathogenesis;Pathologic Processes;Pathway interactions;Pattern;Population;pre-clinical;predictive signature;Preventive;public health priorities;Race;racial difference;racial diversity;racial minority;racial population;Research;Rest;sex;Smoking;socioeconomics;Stage at Diagnosis;Structure;tau-1;therapy development;Training;training data;trend;United States;United States National Institutes of Health;Validation;vascular cognitive impairment and dementia;vascular risk factor

PROJECT_TITLE: Multiethnic machine learning brain signatures of ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that relies almost exclusively on neoadjuvant chemotherapy as the standard of care treatment. Because ~50% of TNBC patients are left with residual disease after chemotherapy, finding alternative treatment options is critical. This proposal aims to address this need by investigating and targeting a potential mechanism of heightened mitochondrial oxidative phosphorylation in residual TNBC.

PI_NAMEs: PENDLETON, KATHERINE ELLEN (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Ablation;Acetates;Acetyl Coenzyme A;Acetylcarnitine;Address;Adjuvant Chemotherapy;Aftercare;aggressive breast cancer;Alternative Splicing;alternative treatment;Automobile Driving;Biological Assay;Biopsy;BODIPY;Breast;Breast Cancer cell line;Breast Cancer Patient;Buffers;Cancer Burden;cancer subtypes;Carboplatin;Carnitine;Carnitine O-Acetyltransferase;Cell Line;Cell Survival;Cells;Cessation of life;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Citric Acid Cycle;Coenzyme A;Collaborations;Complementary DNA;CRISPR/Cas technology;Cytosol;Data Set;Decarboxylation;docetaxel;Energy-Generating Resources;Enzyme Inhibitor Drugs;Enzymes;etomoxir;Exhibits;expression vector;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Feedback;Genes;Genetic Transcription;Genus Hippocampus;Glucose;Immune system;Immunocompetent;Impairment;improved;In Vitro;in vivo;in vivo Model;inhibitor;Knock-out;Left;Levocarnitine;Levocarnitine Acetyl;lipid metabolism;Lipids;long chain fatty acid;Measures;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;NOD/SCID mouse;Nonmetastatic;Oncologist;oxidation;Oxidative Phosphorylation;Palmitates;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phosphorylation;Play;prevent;Production;Prognosis;Proliferating;Protein Isoforms;Proteins;Proteomics;Pyruvate;pyruvate dehydrogenase;Regulation;Residual Cancers;Residual Neoplasm;Residual state;Resistance;RNA;Role;Stains;standard of care;Stress;targeted treatment;Testing;Therapeutic;Transcript;transcriptomics;Transfection;Transferase;Translations;Transmission Electron Microscopy;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor xenograft;tumor-immune system interactions;Western Blotting;Xenograft procedure

PROJECT_TITLE: Investigating the role of CRAT as a driver of triple negative breast cancer chemoresistance


PHR: Project Narrative The Research Projects Core (RPC) of the COBRE Center for Neuroplasticity will facilitate the discovery of new approaches and agents to combat diseases affecting the nervous system like Alzheimer’s, Parkinson’s and disabilities resulting from nervous tissue trauma and injury. This Core integrates enthusiastic scientists using diverse model systems and strategies in modern world-class facilities to better understand how the brain and the nervous system adapt to challenging changes during health and disease. The scientific activity will also nurture the next generation of neuroscientific leaders.

PI_NAMEs: SILVA, WALTER I (contact)

PROJECT_TERMS: addiction;Affect;Agreement;Alcohols;Alzheimer's Disease;Area;Award;base;Behavior;Biological Models;Brain;career development;Centers of Research Excellence;combat;Core Facility;Development;Dimensions;disability;Disease;Educational workshop;Electrophysiology (science);Entrepreneurship;Environment;Equipment;equipment acquisition;Evaluation;Evolution;Experimental Models;Fostering;Funding;Funding Agency;Goals;Government;Grant;Health;higher education;Individual;Industry;Infrastructure;Institution;instrumentation;Investigator-Initiated Research;Legal patent;Measures;Methodology;Modality;Modeling;Modernization;Nature;Nerve Tissue;Nervous System;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neuronal Plasticity;Neurosciences;Neurosciences Research;New Agents;next generation;novel;novel strategies;Outcome;Parkinson Disease;Participant;Phase;Pilot Projects;Population;Productivity;programs;Publications;Puerto Rico;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Scientist;Series;skill acquisition;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Source;success;synergism;Teacher Professional Development;Therapeutic;tissue injury;tissue trauma;Training;Training and Education;translational applications;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Projects Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Liver Disease;Patient Safety

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Organic anion transporting polypeptides OATP1B1 and OATP1B3 mediate the uptake of many drugs and endogenous compounds from blood into the liver. The proposed research will elucidate novel regulatory mechanisms that modulate the function of these important liver- specific transport proteins. Such information is essential to predict clinically relevant drug-drug and drug-disease interactions.

PI_NAMEs: YUE, WEI  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Abbreviations;Acetylation;Adverse drug event;Aging;Anti-diabetic Drugs;Antibiotics;Antineoplastic Agents;Biochemical;Blood;Cardiac Glycosides;Carrier Proteins;Cell Line;Cell model;Clinical;clinical predictors;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Deacetylase;Deacetylation;Disease;drug disposition;Drug Interactions;Drug Transport;Epigenetic Process;epigenetic regulation;experimental study;FDA approved;Functional disorder;Genetic Engineering;Goals;Hepatocyte;Histone Acetylation;Histone Deacetylase Inhibitor;Histone Deacetylation;Histones;Human;Immunosuppressive Agents;inhibitor;inhibitor therapy;Knock-out;Knowledge;Lipids;Liver;Liver diseases;loss of function;Lysine;Mediating;Membrane;Messenger RNA;Modeling;Molecular;Muscle;Mutagenesis;new chemical entity;novel;novel strategies;novel therapeutics;OATP Transporters;Outcome;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Post-Translational Protein Processing;Post-Translational Regulation;Protein Acetylation;Proteins;Proteomics;rational design;Regulation;Research;Rhabdomyolysis;Role;side effect;Site;stable cell line;success;Testing;Toxic effect;Toxic Environmental Substances;Toxin;tubacin;uptake;Vorinostat;Work

PROJECT_TITLE: Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Coronaviruses;Data Science;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: ADMINISTRATION

PHR: Public Health Relevance Statement As one of its 5 strategic goals, the NIH has identified “workforce development” in biomedical data science as important for the coming decades. As such, NIH has called for integrative training in data-science approaches through curricula using a mentored research. The proposed T35 short-term training program is designed to engage eligible predoctoral students with diverse backgrounds particularly those from underrepresented groups, and from the physical and/or quantitative sciences to explore Big Data health science research in HIV, COVID-19, and other infectious diseases in South Carolina (SC) and the United States (US).

PI_NAMEs: HIKMET, NESET ;OLATOSI, BANKOLE  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Academic Training;Active Learning;Age;Area;Artificial Intelligence;Behavioral Sciences;Big Data;big-data science;Biochemistry;Biomedical Engineering;Businesses;Caring;Cessation of life;Chemistry;Clinical Sciences;college;Communicable Diseases;community engagement;comorbidity;Competence;COVID-19;Data;data streams;Databases;Development;disease transmission;doctoral student;Electronic Health Record;Entrepreneurship;Environment;experience;Faculty;faculty mentor;Fostering;Funding;genomic data;Genomics;Goals;hands on research;Health;health data;health science research;Health Sciences;Healthcare;HIV;HIV/AIDS;Hour;improved;Infectious Diseases Research;Information Technology;Infrastructure;innovation;insight;Intelligence;interest;Knowledge;Link;Machine Learning;Manuscripts;Mathematics;Measures;Mentors;Methodology;Mission;mobile computing;National Institute of Allergy and Infectious Disease;next generation;Outcome;Patients;Persons;pre-doctoral;Process;programs;Public Health;Qualifying;recruit;Research;Risk;Scholars Program;Schools;Science;Scientist;social media;Social Sciences;South Carolina;statistics;Strategic Planning;Students;summer research;Talents;Technology;Training;training opportunity;Training Programs;Underrepresented Populations;United States;wearable device

PROJECT_TITLE: Big Data Health Science Scholar Program for Infectious Diseases

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Human Genome;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Cannabis is consumed by millions of Americans, moreover, changes in public attitudes and regulatory policies are expected to further increase the number of users. Levels of Δ9-tetrahydrocannabinol (THC) in cannabis are also rising and the use of high potency cannabis (containing high levels of THC) is associated with an increased risk of adverse health consequences. To address the corresponding lack of knowledge regarding targets of high potency cannabis and their role in negative health outcomes, we propose a pharmacogenomic screen in the BXD mouse population to identify genetic variation in effector proteins that regulate cannabinoid receptor signaling and mediate acute physiological responses to high-dose THC.

PI_NAMEs: MOORE, BOB MACK;MULLIGAN, MEGAN KATHLEEN (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Absence of pain sensation;Accounting;Acute;Address;Alleles;American;antinociception;Attitude;Behavior;Behavioral;Biological;Brain;Brain region;Candidate Disease Gene;candidate validation;cannabinoid receptor;Cannabinoids;Cannabis;Chromosome Mapping;CNR1 gene;cohort;Complex;Consumption;Corpus striatum structure;Data;differential expression;Dose;Exposure to;Female;Genes;Genetic;Genetic Engineering;genetic variant;Genetic Variation;genomic locus;Genomics;Genotype;Goals;Health;Heritability;Human;Hybrids;Inbred Mouse;Individual;Individual Differences;Knowledge;Liquid Chromatography;Locomotion;male;Maps;marijuana use;Mediating;Membrane;Mental Depression;Motor;mRNA Expression;Mus;natural hypothermia;Neurons;neurotransmission;Outcome;Parents;Pharmacogenomics;pharmacologic;Phenotype;Physiological;Policies;Population;Proteins;Proteome;Proteomics;Psychotropic Drugs;Public Policy;Quantitative Trait Loci;receptor;Receptor Activation;Receptor Signaling;Recombinants;regional difference;Regulation;response;Risk;Rodent;Role;sex;Sex Differences;Signal Pathway;Signal Transduction;Spectrometry;Testing;Tetrahydrocannabinol;THC exposure;Tissues;trafficking;trait;transcriptome;transcriptome sequencing;United States;Validation;Variant;virtual;Work

PROJECT_TITLE: Identification of gene variants mediating the behavioral and physiological response to THC

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Identifying and targeting the subset of lymphoma cells that maintain and repopulate the disease is a critical unmet need. Building on our strong foundational work and interdisciplinary expertise, we have devised a bold strategy to provide definitive answers on how stem-like populations arise from mature lymphocytes and how are they hijacked by specific mutations to promote disease progression and relapse. Our studies promise to transform the way we understand and treat lymphoma.

PI_NAMEs: APOSTOLOU, EFFIE  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Affect;Aftercare;Antigens;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Biological Assay;Cancerous;Cell Reprogramming;Cell Survival;Cells;Chromatin;chromatin remodeling;Dependence;derepression;Development;Diagnostic;Disease;Disease Progression;Down-Regulation;Endowment;Enhancers;Epigenetic Process;experience;gain of function;Gene Expression Profile;Genetic;Genetic Transcription;Genomics;Goals;Hematopoietic Neoplasms;Histone H1;Image;Immuno-Chemotherapy;Immunobiology;in vivo;Incidence;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;large cell Diffuse non-Hodgkin's lymphoma;leukemia;loss of function;Lymphoma;Lymphoma cell;Lymphomagenesis;Maintenance;Mature B-Lymphocyte;Mature Lymphocyte;Molecular;mouse model;multiple omics;Mutation;Nature;novel;pathogen;Patients;Population;prevent;progenitor;programs;Property;Publishing;Reaction;Regimen;Relapse;relapse patients;relapse risk;Research;Residual state;Resistance;response;Role;Sampling;self-renewal;Signal Transduction;single cell technology;Solid Neoplasm;stem;stem cell genes;stem cells;stem-like cell;stemness;Structure of germinal center of lymph node;synergism;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;TNFSF5 gene;transcriptional reprogramming;tumor;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lymphatic Research;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Kaposi’s Sarcoma-associated herpesvirus (KSHV) is a major cause of AIDS-associated cancers and thus represents a significant public health burden. The proposed work seeks to establish how KSHV triggers cellular proliferation in an improved cell culture model of the KSHV-associated cancer Kaposi’s sarcoma. Results will be impactful, because they will improve our understanding of mechanisms underlying Kaposi’s Sarcoma and our ability to develop therapeutic strategies for this cancer.

PI_NAMEs: GOTTWEIN, EVA HENRIETTE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Actins;Address;Adherens Junction;Adhesions;AIDS related cancer;Automobile Driving;Binding;Blood Vessels;cadherin 5;Cell Culture Techniques;Cell Cycle;Cell Cycle Arrest;Cell Proliferation;Cell Shape;cell type;Cells;Complex;Contact Inhibition;Cyclin-Dependent Kinase Inhibitor;Cytoskeleton;Data;Endothelial Cells;gene product;Genome;Gentian Violet;Herpesviridae Infections;Human;Human Herpesvirus 8;improved;Individual;Infection;inhibitor;innovation;Kaposi Sarcoma;Knowledge;Left;Lymphatic Endothelial Cells;Lytic;Malignant Neoplasms;Measures;Mediating;Mentored Clinical Scientist Development Program;Messenger RNA;MicroRNAs;Modeling;monolayer;mutant;neoplastic cell;Normal Cell;Oncogenic;Pathway interactions;Phenotype;Process;Proliferating;Proliferation Marker;Proteins;Protocols documentation;Public Health;Repression;Role;Solid Neoplasm;Stains;Study models;Supporting Cell;Testing;Therapeutic;Therapeutic Intervention;trafficking;Transcript;tumor;tumorigenesis;Viral;Viral Genes;Work

PROJECT_TITLE: Mechanisms of KSHV-induced endothelial cell loss of contact inhibition of proliferation

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Aging;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE  The proposal requests partial support for the 14th through the 18th Annual Meetings of the Organization for the Study of Sex Differences (OSSD). The 14th Annual Meeting, entitled “Sex Differences Across the Lifespan”, will be held in Marina del Rey, Los Angeles, California, in May 4-7, 2020, with a particular focus on the effect of sex on age-related diseases. The OSSD is a scientific membership society with the mission to enhance the knowledge of sex/gender differences in human health and disease by facilitating nterdisciplinary communication and collaboration among scientists and clinicians from diverse backgrounds.

PI_NAMEs: ARNOLD, ARTHUR P (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: addiction;Age;age-related disease;aging related;Alberta province;Basic Science;bench to bedside;Biological;Biological Models;California;Canada;career development;Clinical Research;Clinical Sciences;Collaborations;Communication;community engagement;Decision Making;design;Development;Disease;Drug abuse;Education;Educational Models;Educational workshop;Ethnic Origin;Fees;Fostering;Funding;Gender;gender difference;Genetic;Goals;Growth;Health;health disparity;Healthcare;Hormonal;Human;improved;interdisciplinary collaboration;Interdisciplinary Communication;Interdisciplinary Study;interest;International;Knowledge;Leadership;lectures;Life Cycle Stages;life span;Los Angeles;Measures;meetings;men;Mentors;Minority Groups;minority scientist;minority undergraduate;Mission;Molecular;multidisciplinary;Organ;Organizational Objectives;outreach;Participant;Pharmacotherapy;Physicians;Physiology;posters;Process;programs;Public Policy;Publications;Recording of previous events;Recruitment Activity;Request for Proposals;Research;Research Personnel;Role;Science;Scientist;sex;sex as a biological variable;sex chromosome aneuploidy;Sex Differences;Societies;symposium;Syndrome;System;Texas;Therapeutic Intervention;Travel;Treatment Efficacy;undergraduate student;Underrepresented Minority;United States National Institutes of Health;web site;Woman;Work

PROJECT_TITLE: Organization for the Study of Sex Differences Annual Meeting

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: An effective tuberculosis (TB) vaccine to prevent and/or treat pulmonary Mtb infection is urgently needed. We propose to exploit a novel viral vector platform with new Mtb antigens to develop highly effective TB vaccines. These vaccine candidates will expand the current global TB vaccine portfolio and advance TB vaccine research and development with an ultimate goal of ending TB.

PI_NAMEs: LIANG, YUYING ;TISCHLER, ANNA DEGRAFF (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immune response;Adult;Advanced Development;Aerosols;Antibodies;Antibody Response;antigen test;antigen-specific T cells;Antigens;Arenavirus;Attenuated;Bacterial Infections;booster vaccine;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell surface;Cellular Immunity;Cessation of life;Childhood;Communicable Diseases;Complex;Data;design;Development;Diagnosis;Disease;efficacy evaluation;Engineering;Exhibits;fighting;Genome;Goals;Immune response;Immunity;immunogenicity;Immunologics;improved;Individual;Infection;innovation;Knowledge;latent infection;Licensing;lifetime risk;long term memory;Lung;Memory;Modeling;mouse model;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;next generation;novel;Open Reading Frames;pathogen;Phase;Pichinde virus;Population;preclinical evaluation;prevent;Prevention;Preventive vaccine;protective efficacy;Proteins;Pulmonary Tuberculosis;reactivation from latency;Recombinants;recruit;Research;research clinical testing;RNA;Route;Safety;Structure of parenchyma of lung;T cell response;T-Lymphocyte;Testing;Therapeutic;Tuberculosis;Tuberculosis diagnosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccine Research;vaccine response;Vaccines;vector;Viral Vector;Virulent

PROJECT_TITLE: Novel multivalent viral vectored tuberculosis vaccines targeting lung immunity

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Neurosciences

PHR: Project Narrative  In HIV-associated cryptococcal meningitis, altered mental status is a common clinical manifestation and is associated with a significant increase in mortality. There is a considerable lack of understanding as to the exact neurological abnormalities leading to the development of acute altered mental status in cryptococcal meningitis. The objective of this study is to identify the underlying neurological abnormalities that result in the development of altered mental status during cryptococcal meningitis and to identify clinical interventions to reverse these neurological abnormalities and improve survival.

PI_NAMEs: ABASSI, MAHSA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Acute;Address;Adult;Africa;Africa South of the Sahara;Anticonvulsants;antiretroviral therapy;Biochemical;Biological;Biological Response Modifier Therapy;Biometry;Brain;career development;Cell Respiration;Central Nervous System;Central Nervous System Infections;Cerebral Hypoxia;Cerebrospinal Fluid;Cerebrum;Cessation of life;Clinical;Clinical Research;Coma;Communicable Diseases;Congenital neurologic anomalies;Cryptococcal Meningitis;Cryptococcus;Data;Dedications;Delirium;Detection;Development;Development Plans;Diagnosis;Early identification;Electroencephalography;Energy Metabolism;Evidence based intervention;Excess Mortality;experience;Functional disorder;Future;Glasgow Coma Scale;Glucose;Goals;Grant;Guidelines;HIV;HIV/AIDS;Impairment;improved;improved outcome;Infection;innovation;insight;International;Intervention;Intracranial Hypertension;Laboratories;laboratory experience;Leukocytes;Light;low income country;Measurable;Medicine;Meningitis;mental state;Mentors;Mentorship;metabolomics;Minnesota;Monitor;mortality;Neurocognitive;Neurologic;Neuropathogenesis;neuropathology;Oxygen saturation measurement;Pathogenesis;Pathology;Patients;Persons;Practice Management;professor;Pyruvate;Reporting;Research;Research Personnel;Sampling;Seizures;Standardization;Supportive care;Techniques;Testing;therapy design;Time;Training;Uganda;Universities

PROJECT_TITLE: Targeting Neuropathogenesis of Altered Mental Status to Improve Survival in Cryptococcal Meningitis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses invasive E. coli infections, which are common, often antibiotic resistant, and associated with high mortality. Despite this threat, we do not fully understand E. coli pathogenesis and have not developed an antibiotic with novel mechanism to treat E. coli infections in over 50 years. This proposal is relevant to the NIH mission of fostering basic science that leads to novel antibacterial therapeutics as it functionally characterizes a set of genes that appear to be critical in E. coli pathogenesis and that demonstrate homology to a gene that has successfully been developed as a drug target in another organism.

PI_NAMEs: THADEN, JOSHUA T (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Adhesions;Affect;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Area;Award;Bacteremia;Bacteria;Bacterial Adhesins;bacterial genetics;Basic Science;Binding;Bioinformatics;Biological Assay;Biological Markers;career development;Cell Communication;Cell Death;Cells;Charge;Classical Complement Pathway;Clinical;cohort;Complement;Complement 1q;Complement Activation;complement deficiency;Data;Development;Development Plans;Diagnostic;Drug Targeting;E. coli bacteremia;Enrollment;Escherichia coli;Escherichia coli Infections;Escherichia coli Proteins;Event;Fostering;Funding;Genes;Genetic;genetic approach;Genetic Variation;genome sequencing;Genotype;Goals;Gram-Negative Bacterial Infections;high risk;Homologous Gene;Human;Immune response;Impairment;improved;Infection;insight;Invaded;Island;Knowledge;Laboratories;Literature;Mass Spectrum Analysis;Measures;Mediating;Mentors;microbial;Mission;Modeling;Modernization;mortality;mortality risk;Mouse Strains;Mus;novel;novel therapeutics;Organ;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity Island;Patient-Focused Outcomes;Patients;Performance;Phagocytes;Phagosomes;Phenotype;Prognostic Marker;prognostic model;prognostic performance;prognostic value;Protein Secretion;Proteins;Pseudomonas aeruginosa;Public Health;Research;Resistance;Role;scaffold;Scientist;Seminal;Sepsis;Serum;Side;skills;Structure;Surface;Syringes;System;targeted treatment;Testing;Therapeutic;Tissues;translocase;Treatment Factor;Type III Secretion System Pathway;United States National Institutes of Health;Validation;Variant;Virulence;Work

PROJECT_TITLE: Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]