ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE This project will improve our understanding of how noninvasive sensory stimulation reduces pathophysiological markers of Alzheimer’s disease (AD). Using optical microscopy and preclinical models of AD, the effects of neuromodulation on brain metabolism and cerebral hemodynamics will be explored in live brains with cellular resolution. The findings will guide improvements of neuromodulation therapies as an inexpensive, nonpharmacological tool to reduce the AD pathology in humans.

PI_NAMEs: YASEEN, MOHAMMAD ABBAS (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Animal Model;Animals;Astrocytes;auditory stimulus;awake;Biocompatible Materials;Blood flow;Blood Vessels;Brain;brain metabolism;Brain Pathology;Brain region;Cannulas;cellular imaging;Cephalic;Cerebral cortex;cerebral hemodynamics;cerebral oxygenation;Cerebrovascular Circulation;Cerebrum;clinical efficacy;Cognition;combat;cost;Couples;cytokine;design;Development;Effectiveness;Energy Metabolism;Engineering;experimental study;Exposure to;Feedback;Foundations;Frequencies;glial activation;Goals;hemodynamics;Hippocampus;Human;Image;Imaging Techniques;Impaired cognition;improved;Incidence;innovation;insight;intravital microscopy;Investigation;Knowledge;Label;lens;Measurable;Measurement;Measures;Metabolic;Metabolism;Methods;Microglia;Microinjections;microscopic imaging;Microscopy;Morphology;mouse model;Mus;Needles;Nerve Degeneration;Neuroimmune;neuronal circuitry;Neurons;neuroregulation;neurotransmission;neurovascular;neurovascular coupling;novel;Optics;Oxygen;Pathogenesis;Pathologic;Pathway interactions;Patients;Periodicals;Permeability;Pharmacologic Substance;Pharmacotherapy;Photic Stimulation;Pilot Projects;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;preservation;Prevalence;Preventive;Reporting;Research Personnel;Resolution;response;Risk Factors;Sensory;sensory stimulus;Signal Transduction;socioeconomics;Solid;stem;Stimulus;Structure;success;Synapses;Techniques;tool;two photon microscopy;Variant;Visual Cortex;visual stimulus

PROJECT_TITLE: Modulating blood flow and metabolism in Alzheimer's Disease models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Pregnant people are exposed to persistent organic pollutants (POPs) and non-chemical stressors which adversely impact maternal and child health outcomes, including cognitive development in offspring. African Americans, who disproportionally experience elevated rates of adverse maternal and child health outcomes, are also exposed to the highest levels of environmental hazards and social stressors. This research will leverage a prospective birth cohort of African Americans and will apply novel statistical methods to examine infant neurodevelopment in relation to a mixture of prenatal POPs and social stress exposures, better reflecting real-life exposure patterns.

PI_NAMEs: EICK, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: adverse outcome;Affect;African American;African American population;Age;Age Months;Anxiety;Area;Award;Biological;Biological Assay;Biological Markers;Birth;building materials;career;Caring;Characteristics;Chemical Exposure;Chemicals;Child;Child Development;Child Health;clinical practice;Cognition;Cognitive;cognitive development;cohort;Color;Commerce;Communities;Complex Mixtures;Cosmetics;Data;design;Developmental Disabilities;Disparity;early pregnancy;Enrollment;Environment;environmental chemical;Environmental Epidemiology;Environmental Hazards;Environmental Health;ethnic difference;Ethnic Population;experience;Exposure to;First Pregnancy Trimester;follow-up;Food;Furniture;Goals;Health;health disparity;Health Promotion;High Prevalence;high risk infant;Home;Human;Human body;in utero;Individual;Inequality;infancy;Infant;Intervention;Knowledge;Life;Link;low socioeconomic status;man;Marketing;Maternal and Child Health;Measures;Mental Depression;Mentors;Methods;Modeling;Mothers;neurodevelopment;Newborn Infant;novel;offspring;organochlorine pesticide;Outcome;Participant;Pattern;perceived stress;Perinatal;persistent organic pollutants;personal care products;Personal Satisfaction;Persons;Pesticides;Phenotype;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Polychlorinated Biphenyls;Population;Positioning Attribute;Postdoctoral Fellow;postnatal;pre-doctoral;Pregnancy;pregnant;prenatal;prenatal exposure;Prevalence;prevent;prospective;Psychosocial Stress;psychosocial stressors;Public Health;public health intervention;Publications;Questionnaires;racial difference;racial discrimination;racial population;recruit;Research;Research Personnel;Research Priority;Risk;Sample Size;Self Care;Serum;skills;social factors;social stress;social stressor;Societal Factors;sociodemographics;Socioeconomic Status;socioeconomics;Statistical Methods;stressor;Testing;Training;training opportunity;transmission process;United States;Work

PROJECT_TITLE: Cumulative effects of persistent organic pollutants and non-chemical stressors on child development

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (KS)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Recovery from sepsis requires the body to use a large quantity of the body's amino acids and fat stores. These metabolic substrates come from tissues like muscle and fat and serve not only as an energy source but also to support and activate the immune system as well as being used to repair damaged tissues and organs. This application seeks to understand the molecular role of the Yap1/TAZ /CD14 pathway activated in the liver in sepsis and how this pathway specifically regulates whole body metabolism and muscle loss in this process.

PI_NAMEs: KONIARIS, LEONIDAS G. (contact)

PROJECT_TERMS: Acute-Phase Proteins;Acute-Phase Reaction;Amino Acids;Animal Model;Anorexia;Apoptosis;Bacterial Antigens;Binding;Cachexia;Caspase;Catabolic Process;Catabolism;CD14 gene;cecal ligation puncture;Cells;combat;Complex;Data;Development;Eating;Energy Metabolism;Energy-Generating Resources;Enteral;experimental study;Fatty acid glycerol esters;Fatty Acids;Food;Growth;Hepatic;Ileus;Immune;immune activation;Immune system;Immunity;Impairment;improved outcome;In Vitro;in vivo;in vivo evaluation;Inflammasome;Inflammatory;Injury;Innate Immune System;Intervention;Intestines;Knock-out;Knockout Mice;Life;Ligands;Link;Lipopolysaccharides;Literature;Liver;Mechanics;Metabolic;metabolic abnormality assessment;Metabolism;Minerals;Modeling;Molecular;morphometry;Mus;Muscle;Muscle Fibers;Muscle Weakness;Muscular Atrophy;Natural Immunity;NF-kappa B;nuclear factors of activated T-cells;Operative Surgical Procedures;Organ;organ injury;organ repair;Organ Size;Outcome;overexpression;Pathway interactions;pharmacologic;Phosphotransferases;Physical activity;Physiological;Population;prevent;Process;Production;protein purification;Proteins;Recovery;repaired;respiratory;response;Rest;Role;Sepsis;septic;Signal Transduction;Source;Survivors;Time;tissue regeneration;tissue repair;Tissues;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome sequencing;wasting;Water consumption

PROJECT_TITLE: Yap1/TAZ and CD14 in the Catabolic Response to Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SURG-P (01)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Candida parapsilosis is a major fungal pathogen that can cause invasive fungemia as a result of antimicrobial therapy-induced collateral damage to the human intestinal microbiota. This project aims to develop biology- based and data-driven mathematical models directly from patient data to investigate the ecological mechanisms underlying the intestinal expansion of C. parapsilosis in immunocompromised patients. Additionally, this project will establish a generalizable computational framework that enables the rational design of probiotic-based antifungal therapy to reduce the risk of intestinal C. parapsilosis expansion.

PI_NAMEs: LIAO, CHEN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Allogenic;Anti-Bacterial Agents;anti-cancer research;anti-fungal agents;anti-microbial drug;Antibiotics;Antifungal Therapy;antimicrobial;Bacteria;bacterial community;Bacterial Infections;bacterial metabolism;bacteriome;Bioinformatics;Biology;breakthrough infection;Candida;career;Clinical;Clinical Data;cohort;Communicable Diseases;Communities;Complex;Computational Biology;computational platform;computer framework;Computer Models;curative treatments;Data;Data Analyses;Data Set;data-driven model;Dedications;deep neural network;Dependence;design;Doctor of Philosophy;Ecology;Educational process of instructing;enteric pathogen;Environment;experimental study;fecal microbiome;Fungemia;fungus;Genome;genome-wide;genomic variation;Goals;Grant;Growth;gut microbiome;gut microbiota;Health Care Costs;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Human;Immunocompromised Host;improved;In Vitro;in vivo;Infection;inhibitor;insight;interest;Intestines;Laboratories;Leadership;leukemia/lymphoma;Life;Link;Machine Learning;mathematical model;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Metabolic;metabolomics;Metadata;Metagenomics;microbial community;microbiome;microbiome composition;microbiota;model development;Modeling;Molecular;mycobiome;Mycoses;Neural Network Simulation;neurodevelopment;novel;Nutrient;Nutrient availability;Organism;Outcome;pathogenic fungus;pathogenic microbe;Patients;Phase;Play;Postdoctoral Fellow;predictive modeling;Predisposing Factor;prevent;probiotic therapy;Probiotics;programs;prophylactic;Prophylactic treatment;rational design;Research;Research Institute;Resources;Risk Assessment;Risk Reduction;Role;Sampling;screening;Sepsis;simulation;skills;Source;Systems Biology;Techniques;Testing;Therapeutic;Training;Transplant Recipients;Variant

PROJECT_TITLE: Unraveling the ecology of intestinal fungal expansion in immunocompromised patients through computational modeling and machine learning

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ORG_CITY: DALLAS

ORG_NAME: VA NORTH TEXAS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Neurologic and mental health complications are among the most common post-acute sequelae of COVID-19 infection. A recent study showed that Veterans surviving COVID-19 had over 80% increased risk of mental health diagnosis over the subsequent year. They might linger or worsen over time. Characteristics, predictors, and mechanisms of these complications remain unclear. We are planning to leverage a well-characterized cohort of Veterans with and without COVID-19 diagnosis to administer careful serial neuropsychological testing over up to three years to better characterize these complications and to establish whether antiviral therapy is preventive of cognitive impairment. We will also study blood biomarkers of brain damage and advanced imaging on a subset of these patients to determine whether these predict and/or explain the neurocognitive changes. A successful completion of these aims will establish benchmarks to analyze and manage neurologic and mental health changes following acute COVID-19 infection.

PI_NAMEs: BEDIMO, ROGER  (contact);VITTOR, AMY YOMIKO

PROJECT_TERMS: 2019-nCoV;Accounting;Acute;acute COVID-19;Acute Disease;Address;Aerobic Exercise;Alpha Virus;Alzheimer's Disease;Anti-viral Agents;Anti-viral Therapy;arterial spin labeling;Assessment tool;Benchmarking;Biological Markers;biomarker validation;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain imaging;Brain Injuries;brain metabolism;California;Carbon Dioxide;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;Characteristics;Clinical;Clinical Data;Cognitive;cognitive change;cognitive function;cognitive testing;cohort;Communicable Diseases;comorbidity;Complement;Confusion;COVID-19;COVID-19 diagnosis;COVID-19 patient;COVID-19 survivors;cribriform plate;cytokine;Data;Demyelinations;Depressive disorder;Development;Diagnosis;Disabling;emerging pathogen;endophenotype;Epidemic;Epidemiology;Exposure to;Fick method;Functional disorder;Functional Imaging;Future;Goals;Guidelines;Health;Hematogenous;Image;imaging biomarker;Immunity;Immunologic Markers;Immunologics;Immunology;Impaired cognition;Incidence;Infection;Inflammation;Inhalation;Injury;insight;Intervention;Invaded;Knowledge;Link;Long COVID;longitudinal analysis;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Memory Loss;Mental Health;metabolic rate;Metabolism;mild cognitive impairment;Monitor;multidisciplinary;multiplex assay;Natural History;Nerve Degeneration;Nervous System Trauma;Neurocognitive;neuroimaging;Neurologic;Neurologic Symptoms;Neurology;Neuronal Injury;Neurons;Neuropsychological Tests;novel;Outcome;Oxygen;pandemic disease;Participant;Pathogenicity;Patient Outcomes Assessments;Patient Self-Report;patient subsets;Patients;Pattern;Persons;Positron-Emission Tomography;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Post-Traumatic Stress Disorders;predictive marker;prevent;Preventive;Prognosis;Prognostic Factor;Reporting;Research Personnel;response;Risk;Risk Factors;Risk Reduction;Route;Sampling Studies;SARS-CoV-2 antiviral;SARS-CoV-2 infection;Severities;Sleeplessness;Standardization;structural imaging;Structure;study population;systemic inflammatory response;Tablets;Technology;Testing;Therapeutic;Thinness;Time;tool;treatment strategy;Universities;Veterans;Viral;Work

PROJECT_TITLE: Characteristics and Determinants of Post-COVID Neurocognitive Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFA-K (01)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The opioid epidemic continues unabated, yet adoption of highly efficacious medication treatment remains low, particularly in residential addiction treatment programs. This application will promote the development of skills in an outstanding postdoctoral researcher whose research focuses on the implementation of state policy interventions targeting the scale-up of evidence-based practices such as medication treatment in addiction treatment settings. This award will provide the applicant with exceptional mentorship and training opportunities to gain skills needed during the K-99 phase to launch a successful career as an independent investigator during the R-00 phase conducting novel research aimed at reducing the public health harms caused by the opioid epidemic by improving access to evidence-based practices that promote long-term recovery from opioid use disorder.

PI_NAMEs: MILES, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Acceleration;addiction;Adoption;Area;Attitude;Award;Beds;beneficiary;Big Data;Buprenorphine;career;career development;Categories;Characteristics;Climate;Clinical;Controlled Environment;Data;demographics;design;Diagnostic Services;Disease;econometrics;Educational workshop;effectiveness testing;efficacious treatment;Ensure;Environment;evidence base;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Fatality rate;financial incentive;Fostering;Foundations;Future;Goals;health service use;heuristics;high risk;implementation framework;implementation process;implementation strategy;Improve Access;improved;Incentives;Individual;informant;Information Systems;Institution;Intervention;Interview;large datasets;Leadership;Learning;long term recovery;longitudinal analysis;Medicaid;medication for opioid use disorder;Mentors;Mentorship;Methadone;Methods;Modality;Modeling;Naltrexone;National Institute of Drug Abuse;Natural experiment;New Jersey;novel;Observational Study;opioid epidemic;opioid treatment program;opioid use disorder;Outcome;Overdose;overdose death;Participant;Pathway interactions;Pattern;Performance;Pharmaceutical Preparations;Phase;Policies;Postdoctoral Fellow;programs;Provider;Psyche structure;Public Health;Research;Research Design;Research Personnel;Residential Treatment;Risk;scale up;Services;skill acquisition;skills;standard of care;Strategic Planning;Structure;Testing;therapy development;timeline;Training;training opportunity;treatment planning;treatment program;trend;trend analysis;United States Centers for Medicare and Medicaid Services;uptake;Variant;Volatilization;Vulnerable Populations;waiver;Work

PROJECT_TITLE: Scaling-up Medication for Opioid Use Disorder in Residential Treatment Settings

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Approximately 14% of adolescents (As) and 10% of young adults (YAs), aged 18-24, use electronic nicotine delivery systems (ENDS) and are at risk for health harms from toxicant/carcinogen exposure and long-term nicotine addiction. Evidence on how to help A/YA ENDS users quit is scant with only one randomized controlled trial which used the texting program, This is Quitting. The proposed work will identify strategies used by A/YAs to quit ENDS, probe for strategies to increase cessation engagement, and also test the feasibility in YAs of adding both financial incentives and nicotine replacement therapy to the existing cessation program, This is Quitting.

PI_NAMEs: WILLIAMS, BRIAN S (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 17 year old;Abstinence;Achievement;Address;Adolescent;Adolescent and Young Adult;Adult;aged;Applications Grants;Award;Carcinogen exposure;career development;Cigarette;Clinical Trials;Cohort Studies;combustible cigarette;Counseling;critical period;Data;Data Analyses;Databases;Dependence;design;e-cigarette cessation;Education;education planning;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Enrollment;Epidemic;Evaluation;Evidence based treatment;experience;Experimental Designs;Failure;feasibility testing;financial incentive;Frequencies;Future;Goals;Grant;Health;improved;interest;Intervention;Interview;Knowledge;Leadership;Longitudinal cohort;Manuscripts;Measures;Mentors;Methodology;never smoking;Nicotine Dependence;nicotine replacement;nicotine use;Participant;Persons;Pharmaceutical Preparations;Physicians;Population;Population Assessment of Tobacco and Health;programs;psychosocial;Publishing;Qualitative Research;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Ethics;Research Proposals;Resources;response;Risk;Sampling;Scientist;skills;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Structure;success;Text;Text Messaging;Time;Tobacco;tobacco products;Tobacco use;toxicant;Toxicant exposure;Training;Treatment Effectiveness;United States National Institutes of Health;vaping;Work;Writing;young adult

PROJECT_TITLE: Addressing the Vaping Epidemic in Adolescents and Young Adults: Advancing our Understanding of Cessation Treatment and Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative We propose to use large-scale data, such as the Alzheimer's Disease Sequencing Project (ADSP), systematically collected clinical and imaging data, and observations in the scientific literature, to identify factors that increase the risk of and protection against dementia. Motivated by the great success of knowledge graph (KG) as a cornerstone of almost all successful cognitive systems in industry, we propose to construct a novel and comprehensive AD-related knowledge graph (AD-KG) platform based on multiple curated resources, literature, and a large-scale AD-related database with multiple types of high-dimensional data in different studies that have different missing-data patterns.

PI_NAMEs: LI, YUN ;ZHU, HONGTU  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;American;Area;Atlases;behavioral neurology;big biomedical data;Biological;Biological Models;biomedical data science;Brain;Breathing;Classification;Clinical;Cognitive;cognitive enhancement;cognitive system;cognitive training;Collection;Communities;Companions;Complement;complex data;Computer software;connectome;cost;Data;Data Analyses;data harmonization;data imputation;data modeling;Data Science;Data Set;Data Sources;database structure;Databases;Dementia;Detection;Development;Diagnosis;Disease;disorder subtype;diverse data;drug repurposing;Drug usage;Early Diagnosis;Effectiveness;experience;FAIR principles;Foundations;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genomics;Genotype;Graph;graph knowledge base;high dimensionality;Image;image processing;imaging genetics;improved;Individual;Industry;infancy;information organization;Infrastructure;innovation;insight;Joints;knowledge graph;Laboratories;large scale data;Late Onset Alzheimer Disease;Literature;Maps;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidimensional data;multidisciplinary;Multifactorial Inheritance;Multiomic Data;multiple omics;Natural Language Processing;neuroimaging;neuropsychiatric disorder;Neurosciences;novel;novel diagnostics;novel therapeutic intervention;Outcome;Participant;Pathogenesis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Population;Prevention;protective factors;Public Health;Quality Control;Records;Research;Resources;response;Risk;Risk Factors;search engine;Semantics;statistics;Structure;success;symptom treatment;Techniques;tool;transcriptome;Update

PROJECT_TITLE: Construction and Application of Comprehensive Knowledge Graphs for Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (02)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Opioids;Orphan Drug;Pain Research;Patient Safety;Rare Diseases;Sickle Cell Disease

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative  Acute pain, brought on by vaso-occlusion, is the most frequent cause of hospital admission in sickle cell disease and greatly reduces overall health and social well-being. The amino acid citrulline increases nitric oxide, which has vasodilatory properties and the potential to relieve vaso-occlusion. In this clinical trial, we will investigate whether the addition of this novel treatment, intravenous L-citrulline, will significantly impact opioid use and clinical outcomes in this high risk population.

PI_NAMEs: CHAPMAN, KIMBERLY ANN;MAJUMDAR, SUVANKAR  (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Abnormal Hemoglobins;Acute;acute chest syndrome;Acute Pain;addiction;Affect;African ancestry;alternative treatment;Amino Acids;arginase;Arginine;base;beta Globin;Biochemistry;Biological Availability;Biological Markers;Blood flow;Blood Vessels;Carbamyl Phosphate;Cessation of life;Characteristics;Citrulline;Clinical;Clinical Trials;Common Terminology Criteria for Adverse Events;Complication;Constipation;Controlled Clinical Trials;Data;Disease;DNA;Dose;Double-Blind Method;Drug Kinetics;Emergency department visit;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Erythrocytes;Event;Family;Frequencies;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;Glutathione;Health;Health Care Costs;healthcare burden;Hemoglobin;Hemolysis;high risk population;Hospital Administration;Hospitalization;Hour;improved;Individual;Inflammation;Inflammatory;Infusion procedures;Interleukin-1 beta;Interleukin-6;Intervention;Intestines;Intravenous;intravenous administration;Length of Stay;Ligase;Link;Lung;Measures;Mitochondria;Modality;Monitor;Morbidity - disease rate;Mus;Mutation;Natural regeneration;Nitric Oxide;Nitric Oxide Pathway;Nitric Oxide Synthase;novel;novel therapeutics;Opiate Addiction;opiate tolerance;Opioid;Opioid Analgesics;opioid injection;opioid sparing;opioid therapy;opioid use;Other Genetics;Outcome;oxidative damage;Pain;Pain management;Pain quality;parenteral administration;Pathogenesis;Patients;Perfusion;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase I trial;Phase II Clinical Trials;Photoplethysmography;Placebo Control;Placebos;Plasma;Play;Prediction of Response to Therapy;Production;Property;Pruritus;Publishing;Quality of life;Randomized;Rare Diseases;Reaction;response;Risk;Role;Running;Serious Adverse Event;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickle vasoocclusion;side effect;Social Well-Being;standard of care;success;Supplementation;Surrogate Markers;Testing;Time;tissue oxygenation;Tissues;TNF gene;Treatment outcome;treatment response;United States;urea cycle;Variant;vaso-occlusive crisis;Vasodilator Agents;Ventilatory Depression;Vulnerable Populations

PROJECT_TITLE: A randomized double-blind, placebo-controlled phase 2 clinical trial of intravenous citrulline for vaso-occlusive crisis in sickle cell disease

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Frequent brain examinations are an important tool for monitoring patients after brain injury, but if excessive, may cause sleep disruption and worsened outcomes in hospitalized patients. Interrupting sleep may make people confused (delirious) and may ultimately increase risk for dementia similar to Alzheimer’s disease. Improving patients’ sleep in the intensive care unit may improve their outcomes, so this project studies whether checking brain status hourly versus every-other-hour impacts sleep quantity and short or long-term cognitive outcomes.

PI_NAMEs: LABUZETTA, JAMIE NICOLE (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;Acute Brain Injuries;Address;Age;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Apolipoprotein E;Area;Benefits and Risks;Biometry;Brain;Brain Injuries;Caring;Cerebral hemisphere hemorrhage;Characteristics;Clinical;clinical practice;Cognition;Cognitive;Cognitive deficits;cognitive neuroscience;Community Healthcare;Confusion;Critical Care;Critical Illness;Data;Delirium;Dementia;dementia risk;design;Deterioration;Development;didactic education;Educational Curriculum;Elderly;Environment;Evaluation;experience;Frequencies;Funding;Goals;graduate student;Grant;Health;Hospitalization;Hour;human subject protection;Impaired cognition;improved;improved outcome;improvement on sleep;Incidence;innovation;Institution;Intensive Care Units;Intervention;Knowledge;Length of Stay;Level of Evidence;Liquid substance;memory consolidation;Memory impairment;Mentors;Mentorship;Methods;Middle Insomnia;modifiable risk;Monitor;mortality;Neurocognitive;Neurologic;Neurologic Examination;Neurology;neurophysiology;Neuropsychology;Neurosciences;older adult;older patient;Outcome;Patient Care;Patient Monitoring;patient oriented research;Patients;Persons;Phenotype;Physicians;Physiological;poor sleep;primary outcome;Protocols documentation;radiological imaging;Randomized;Recommendation;Recovery;REM Sleep;Research;Research Activity;Research Personnel;Risk;Risk Factors;risk sharing;Safety;Scientist;skills;Sleep;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep quantity;Societies;standard of care;Time;tool;Training;Training Activity;Vision;Work

PROJECT_TITLE: Impact of Hourly Neurochecks in Critically Ill Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Rare Diseases;Rehabilitation;Sickle Cell Disease;Social Determinants of Health;Stroke;Telehealth

PHR: PROJECT NARRATIVE Children and adolescents with sickle cell disease are at risk for disease-related cognitive deficits that often impact working memory function and contribute to poor academic achievement and attainment. Prior research shows that a home-based, eHealth working memory training program (Cogmed) leads to significant improvement in working memory for youth with sickle cell disease but adherence to the training is a concern. This study will examine a novel treatment approach by combining Cogmed working memory skills training with social support components and memory strategy training to improve adherence and broaden access to this efficacious intervention.

PI_NAMEs: HARDY, STEVEN JAMES (contact)

PROJECT_TERMS: Academic achievement;Address;Adherence;Adolescent;Adult;Affect;Age;Anemia;arm;Behavior Therapy;Black race;Caring;Central Nervous System;Cerebral Infarction;Child;Childhood;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive rehabilitation;cognitive skill;Cognitive Therapy;cognitive training;cohort;comparison group;Data;Diffuse;digital;Disease;disorder risk;Dose;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;efficacious intervention;efficacious treatment;eHealth;Event;evidence base;Exercise;Exhibits;experience;Family;Fostering;frontal lobe;Future;Genotype;Goals;Head;Home;Impaired cognition;Improve Access;improved;Incentives;Individual;innovation;Intervention;Interview;Investigation;Life;medication compliance;member;Memory;Memory impairment;Modeling;Neurologic;Newborn Infant;novel;novel strategies;Outcome;Participant;Patients;peer;Performance;Persons;Pilot Projects;Population;programs;Published Comment;Quality of life;Randomized, Controlled Trials;rehearsal;Relationship-Building;Research;Research Support;Resources;Rewards;Risk;screening;Semantics;Shapes;Short-Term Memory;Siblings;Sickle Cell Anemia;skills;skills training;social;Social support;sociodemographic factors;Stroke;success;Tablet Computer;telephone coaching;Testing;Therapeutic;Time;Training;Training Programs;Transportation;treatment adherence;Treatment outcome;United States;Update;verbal;videoconference;Visuospatial;Youth

PROJECT_TITLE: A Pilot Study of an Enhanced Program to Promote Adherence to eHealth Cognitive Rehabilitation in Sickle Cell Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: GENETICS

PHR: Project Narrative Black Americans face a disproportionately high risk of developing incident cognitive impairment and Alzheimer’s disease and related dementias (ADRD), compared to non-Hispanic White adults, but the biological mediators underlying this elevated risk are not well understood. The proposed research will use a novel high- throughput proteomics platform to measure 3,072 plasma proteins in Black and White participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study and evaluate relationships of these proteins with ADRD risk factors, incident cognitive impairment, and trajectories of cognitive function. Results of this research may identify risk factors for impaired cognitive health and biological pathways that amplify racial disparities in ADRD.

PI_NAMEs: OLSON, NELS C.;RAFFIELD, LAURA M (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;biobank;Biological;Biological Markers;biracial;Black American;Black race;C-reactive protein;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;Chronic;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Communities;Data;database of Genotypes and Phenotypes;Dementia;dementia risk;depressive symptoms;design;Discrimination;Disease;Disparity;Education;education access;Educational Status;experience;Exposure to;Face;Female;follow-up;Functional disorder;Genes;genetic variant;genome resource;genome wide association study;genome-wide;Genotype;Glial Fibrillary Acidic Protein;Health;Health Disparities Research;health disparity;high risk;immune system function;Impaired cognition;improved;Income;Individual;Inflammation;Inflammatory;Interleukin-6;late life;Light;Link;Longitudinal cohort;Low income;low socioeconomic status;male;Measures;Mediator;Neighborhoods;neural;Neurocognitive;neurofilament;Not Hispanic or Latino;novel;Participant;Pathogenesis;Pathology;Pathway interactions;Patient Self-Report;perceived stress;Persons;Phenotype;Plasma;Plasma Proteins;Population;Poverty;Process;protein biomarkers;Proteins;Proteome;proteomic signature;Proteomics;Psychosocial Stress;public repository;Quantitative Trait Loci;Race;racial disparity;racial population;Reasons for Geographic And Racial Differences in Stroke;recruit;Research;Risk;Risk Factors;risk prediction;Role;Sampling;sex;social health determinants;Stress;stress symptom;Structural Racism;tau Proteins;Testing;ubiquitin C-terminal hydrolase;Work

PROJECT_TITLE: Proteomic biomarkers of incident cognitive impairment in Black and White adults

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Depression;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Rehabilitation;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Low-income older adults are more likely to experience functional disability, and in turn disability often causes emotional, physical, and financial burden in the family members that assist affected older adults. This mixed methods research study will examine how housing disrepair (including problems with one’s home’s roof, walls, or heating) contributes to functional disability in low-income older adults and caregiving burden in their family caregivers, generating foundational knowledge and an understanding of possible modifiable factors and mechanisms from which to develop an intervention. A rigorous training program in mixed methods research, intervention development, family caregiving, and research team leadership will assure career advancement as an independent investigator.

PI_NAMEs: OKOYE, SAFIYYAH MARYAM (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Admission activity;Affect;Aging;American;care giving burden;Career Mobility;Caregiver Burden;caregiver stress;Caregiver well-being;Caregivers;caregiving;Chronic;Clinical;college;Communities;daily functioning;Data;Dedications;Development;disability;disability burden;Discipline of Nursing;effectiveness testing;Emotional;Environment;Environmental Risk Factor;Equity;Expenditure;experience;Exposure to;Family;Family Caregiver;family caregiving;Family member;Family Research;federal poverty level;Financial Hardship;Foundations;Friends;functional disability;functional improvement;Funding;Grant;Health;health disparity;Health Occupations;Healthcare;Heating;Home;Home environment;Hour;Household;Housing;human old age (65+);improved;Income;Inequity;informant;Institutional Racism;Intervention;Interview;Knowledge;Leadership;Long-Term Care;Low income;Medicare;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;Modeling;Modification;Nurse Practitioners;Nursing Homes;older adult;Patients;Personal Satisfaction;Persons;Plumbing;Population;preference;professor;programs;Public Health Schools;Quality of life;Ramp;repaired;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;research study;Risk;Role;Safety;Scientist;secondary analysis;Self Care;Services;social determinants;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;Spouses;Stress;stressor;Surveys;therapy development;Training;Training Programs;trend;United States National Institutes of Health;Universities

PROJECT_TITLE: Addressing Housing Disrepair to Improve Equity in Functional Disability and Caregiver Burden

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: [This study will advance understanding of lumbosacral spinal stenosis (LSS) a major cause of pain and dysmobility in older adult Veterans and a leading cause of disability and loss of independence. Major research studies have shown that surgery for LSS is more effective than usual (medical) management. Still, there are many patients for whom surgery is not possible. There have been reports that temporary use of a modified rolling walker or sleep positioning may help relieve LSS. Going further, our VA team has created a detailed round-the-clock LSS management plan that addresses all daily activities. We will recruit a small group of older adult Veterans with LSS to pilot this comprehensive modified activity program. Our team will support the day- and-night lifestyle modifications and monitor participants closely for relief of symptoms and improvements in walking. We will also assess potential barriers to adopting this therapy by interviewing Veterans and healthcare providers regarding problems with therapy initiation.] If this small study works, we plan to expand the effort.

PI_NAMEs: HOGANS, BETH B (contact)

PROJECT_TERMS: actigraphy;Address;Adopted;Adult;Alternative Therapies;arm;Arthritis;Back;Body Weight;claudication;Clinical;Clinical Research;Complex;cost;daily pain;Data;Dementia;design;Development;Devices;disability;Equipment;EuroQOL;Evaluation;Expectancy;experience;Fatigue;Future;Goals;Health Personnel;Health Services Accessibility;Height;Hip region structure;improved;Inflammation;informant;Instruction;Intervention;Interview;Leg;Leisure Activities;Life Style Modification;Ligaments;Low Back Pain;Measures;Medical;Methods;Modification;Monitor;multiple chronic conditions;Muscle;Nerve;Nerve compression syndrome;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;Odds Ratio;older adult;Operative Surgical Procedures;Outcome Measure;Pain;Pain in lower limb;Pain intensity;Pain interference;Pain Measurement;Participant;Patient Outcomes Assessments;Patients;pedometer;Peripheral Nerves;physical therapist;Pilot Projects;pilot test;Polysomnography;poor health outcome;Posture;pre-clinical;Preparation;pressure;primary care provider;primary outcome;programs;Psychological Factors;Quality of life;Questionnaires;Randomized;randomized, clinical trials;recruit;reduce symptoms;Rehabilitation Outcome;Reporting;Research;research study;Risk;secondary outcome;Sleep;sleep position;sleep quality;Spinal;Spinal nerve root structure;Spinal Stenosis;surgery outcome;Syndrome;System;Therapeutic Trials;therapy design;Time;Training;treatment duration;usability;Veterans;walker;Walking;Weight;Work

PROJECT_TITLE: Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans (LSS-NIPT)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Tau accumulates in pathological aggregates within neurons in AD and is an important fluid biomarker of disease. NPTX2 is a synaptic protein that is also prominently altered in AD and interacts with tau as a biomarker of disease. The proposed research aims to develop new tools to image tau accumulation in vivo and examine its interaction with NPTX2 loss of function using a newly established TgF344-AD x NPTX2f/f rat model. Studies will advance understanding of early-stage AD pathogenesis.

PI_NAMEs: ROH, SEUNG-EON ;WORLEY, PAUL F (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Amyloidosis;area striata;Attention;Axon;Behavioral;Biological Markers;Blood - brain barrier anatomy;BODIPY;Brain;Brain imaging;Brain region;calmodulin-dependent protein kinase II;Cephalic;Cerebrospinal Fluid;cognitive performance;Color;Complex;Detection;Diagnostic;Disease;Disease Progression;Disinhibition;Disulfides;Equilibrium;Excitatory Synapse;Exocytosis;Fluorescence;Functional disorder;Glass;hippocampal pyramidal neuron;Hippocampus;Human;human disease;human subject;Image;imaging agent;Imaging Device;Immediate-Early Genes;Impaired cognition;in vivo;in vivo imaging;Individual;Injections;Interneurons;intravenous injection;Label;Link;Liquid substance;loss of function;Methods;Modeling;Monitor;monocular deprivation;mutant;Mutation;Neocortex;neocortical;neuronal pentraxin;Neurons;novel;Parvalbumins;Pathogenesis;Pathologic;Pathology;Perforation;Performance;Photons;Physiology;presenilin-1;presynaptic;Process;Prosencephalon;Proteins;Rattus;Reporter;Research;Resolution;response;Sensitivity and Specificity;serial imaging;Site;Sleep;Symptoms;Synapses;tau aggregation;tau interaction;tau mutation;tau Proteins;tau-1;Testing;tool;Transmembrane Domain;two photon microscopy;two-photon;Visualization

PROJECT_TITLE: Linking NPTX2 and Tau pathophysiology in AD

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This grant seeks to develop methods for imaging Alzheimer’s disease. New imaging tools for autoradiography, single photon emission computed tomography and positron emission tomography will be developed and characterized. This grant application has the potential for efficient diagnosis, treatment planning and therapeutics development for Alzheimer’s disease.

PI_NAMEs: MUKHERJEE, JOGESHWAR  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3xTg-AD mouse;acute toxicity;Address;Affinity;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;analog;Anterior;Applications Grants;Autopsy;Autoradiography;Binding;Biological Assay;Biological Markers;Blood Tests;Brain;Brain region;Carbon;Characteristics;Clinical;Cognitive;Collaborations;Complement;corticobasal degeneration;Dementia;design;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;dosimetry;Down's Syndrome;drug efficacy;early detection biomarkers;Early Diagnosis;effectiveness evaluation;efficacy study;Emission-Computed Tomography;entorhinal cortex;Exhibits;Female;Fluorine;frontal lobe;Generations;Goals;Grant;Half-Life;Head;Health;Hippocampus;Human;human imaging;Hylobates Genus;Image;Image Analysis;imaging agent;Imaging Device;imaging modality;imaging study;In Vitro;in vivo;in vivo imaging;inhibitor;Investigational New Drug Application;Iodine;Label;Ligands;lipophilicity;male;Measures;Medical center;Meninges;Metabolic;Methods;molecular marker;Mus;nanomolar;Neocortex;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;novel;paired helical filament;Pathologic;Penetration;Photons;Pick Disease of the Brain;Positron-Emission Tomography;Preparation;Process;programs;Progressive Supranuclear Palsy;Protein Isoforms;Radioactive Iodine;Radioisotopes;radioligand;Radiometry;radiotracer;Rattus;Reporting;Research Institute;Rodent;Role;single photon emission computed tomography;Slice;Stains;Structure;success;tau aggregation;tau Proteins;tau-1;Techniques;Temporal Lobe;therapeutic development;Toxic effect;Tracer;Transgenic Mice;Transgenic Organisms;translational potential;treatment planning;Universities;uptake;Variant;Whole-Body Irradiation;Wisconsin;Work

PROJECT_TITLE: Novel Tau-Targeted Radiohalogenated Agents for Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Implementation science (ImS) is a branch of research that focuses on the “use of strategies to adopt and integrate evidence-based health interventions and change practice patterns within specific settings” and is a major initiative of the NIH research portfolio. There is also greater emphasis on eliminating health inequities and social and structural barriers, such as racism, that fuel health inequities, but no other training programs exist that focus on training junior faculty from under-represented minority (URM) backgrounds in Implementation Science. The UCSF Research in Implementation Science for Equity (RISE) program has successfully bridged that gap for the past 8 years, equipping URM scholars to pursue innovative research of interest to the NHLBI and to launch successful careers as independent investigators.

PI_NAMEs: CENE, CRYSTAL WILEY;FERNANDEZ, ALICIA  (contact);HANDLEY, MARGARET ANNE

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Academic skills;Address;Adopted;aluminum sulfate;Award;Biometry;Cardiovascular Diseases;Cardiovascular system;career;career development;Cognitive;cohort;Competence;Data;design;Distance Learning;Educational Curriculum;Educational workshop;Elements;Emotional;Epidemiology;Equity;Ethnic Population;evidence base;Evidence based practice;experience;Faculty;Failure;Feedback;Fostering;Funding;Grant;Health;health equity;health inequalities;Healthcare;implementation science;innovation;interest;Intervention;Knowledge;Lead;lectures;Lighting;Link;Lung;Lung Diseases;Manuscripts;marginalization;marginalized population;meetings;member;Mentors;Methodology;Methods;minority trainee;Mission;National Heart, Lung, and Blood Institute;Outcome Assessment;Participant;Pattern;peer coaching;peer support;Positioning Attribute;Program Development;programs;Protocols documentation;Publications;racial minority population;racism;Research;research and development;Research Methodology;Research Personnel;Resources;Self Efficacy;skill acquisition;skills;social;social health determinants;Social support;structural determinants;success;summer institute;summer program;symposium;theories;therapy design;Time;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;virtual;Work;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The U.S. has the highest rate of maternal mortality among high-income countries and hypertension is a leading cause, contributing to 40% of maternal deaths. To improve the quality and cultural relevance of hypertension care, this proposal will examine the effects of the digital health approach Moms@Home on home blood pressure monitoring in a diverse population of pregnant women with hypertension. By facilitating more timely diagnosis and potentially better blood pressure control with digital health and home blood pressure monitoring, this proposal holds promise to reduce the risk of preventable and devastating clinical events for women with high- risk pregnancies and their children.

PI_NAMEs: KOVELL, LARA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Advisory Committees;Anxiety;Appearance;Asian;Award;behavior change;behavioral health intervention;Biometry;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;career;career development;Caregivers;Caring;Cause of Death;Child;Chronic;Clinic;Clinical;clinical investigation;Clinical Trials;cohort;Communities;cost;cost effective;Counseling;Country;dashboard;Data;Death Rate;Development;Development Plans;Diagnosis;diaries;digital;digital health;digital intervention;Discipline of obstetrics;Disease Management;Electronic Health Record;Electronics;empowerment;Enrollment;ethnic minority population;Event;evidence base;Evidence based intervention;Exclusion;experience;Feedback;fetal;flexibility;Framingham Heart Study;Future;Goals;Health;health data;health equity;health inequalities;Health Personnel;healthy pregnancy;High Risk Woman;High-Risk Pregnancy;Hispanic;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;improved;improved outcome;Income;Infant;Informal Social Control;Informatics;innovation;Intervention;Interview;Lead;Learning;Libraries;literacy;Literature;Lived experience;Master of Science;Maternal Health;Maternal Mortality;Measures;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mHealth;mhealth interventions;mobile application;Mobile Health Application;Morbidity - disease rate;Mothers;Nature;Notification;Operating System;Oral;Outcome;patient engagement;Patients;Perinatal;Persons;Physicians;pilot test;Population;Population Heterogeneity;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnant Women;primary outcome;Professional Organizations;Protocols documentation;Provider;Public Health;racial disparity;racial minority population;racial minority women;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Research Training;Risk Reduction;Safety;Scientist;Secure;Self Care;Self Efficacy;skill acquisition;social cognitive theory;Societies;standard care;standard of care;Standardization;Stroke;Surgeon;Techniques;Testing;Text;therapy design;Time;Training;United States;uptake;Visit;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Development of a Mobile Health Intervention for Blood Pressure Management in Pregnancy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

PHR: PROJECT NARRATIVE When ER+/HER2- breast cancer patients are prescribed endocrine therapy and CDK4/6 inhibitors, it is common for a small percentage of the tumor cells to keep dividing. We suspect these cells could be responsible for drug resistance. The goals of this project are to identify this remnant of tumor cells; to understand how they circumvent treatment with endocrine therapy and CDK4/6 inhibitors; and to discover new signaling proteins that promote resistance. In the future, this information could be used to predict how a patient will respond to endocrine/CDK4/6 inhibitor therapy.

PI_NAMEs: COOK, JEANETTE GOWEN;EMANUELE, MICHAEL JAMES;PURVIS, JEREMY  (contact);WOLFF, SAMUEL CAREY

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Anti-estrogen Therapy;Behavior;Biochemical;Biological Assay;Biological Markers;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;cancer type;CDK4 gene;CDKN3 gene;CDT1 Gene;Cell Cycle;Cell Cycle Progression;Cell Proliferation;Cells;cellular imaging;Clinical Trials;Cyclin D1;Cyclins;Data;Development;Dose;Drug resistance;drug sensitivity;E2F transcription factors;Endocrine;ERBB2 gene;Estrogen receptor positive;Event;event cycle;experimental study;Fractionation;Fulvestrant;Future;G1/S Transition;Genetic;Goals;Heterogeneity;histological stains;hormone therapy;Human;Image;improved;Indirect Immunofluorescence;Individual;inhibitor;inhibitor therapy;Investigation;Knowledge;Label;Link;Mammary Neoplasms;Mass Spectrum Analysis;Metastatic breast cancer;Methods;Microscopy;Modeling;Molecular;Mus;neoplastic cell;next generation;novel;Operative Surgical Procedures;Organoids;patient derived xenograft model;patient response;Patient-Focused Outcomes;Patients;Pattern;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Physiological;Population;Pre-Clinical Model;Primary Neoplasm;Progression-Free Survivals;Proliferating;Proteins;Proteomics;Resected;Resistance;resistance factors;response;Series;Signaling Protein;Surgical Oncology;targeted treatment;Techniques;Testing;Time;trend;tumor;Work

PROJECT_TITLE: Cell cycle paths as a framework for understanding drug resistance in tumor cell subpopulations

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


PHR: Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer causes death in 89% of patients within 5 years of diagnosis. PDAC will become the second leading cause of US cancer deaths by 2040. Pancreatic cancer is deemed a presumptive condition for veterans with exposure to radiation from nuclear weapons and for those who fought in Southwest Asia or the Persian Gulf. PDAC associates with smoking, obesity, diabetes, older age and male gender, all more frequent in veterans than civilians. Clinical progress has been slow in PDAC, and unlike other cancer types, there has been no success using immune therapies. We found that the protein Oncostatin M Receptor (OSMR) causes greater pancreatic cancer aggressiveness. We will study OSMR in mouse models of pancreatic cancer biology and treatment. We will investigate OSMR at the single cell level in human tumors to understand how it changes cell types in the tumor and clinical outcomes.

PI_NAMEs: ZIMMERS, TERESA A (contact)

PROJECT_TERMS: actionable mutation;Asia;Cancer Biology;Cancer Etiology;cancer therapy;cancer type;Cause of Death;Cell Line;cell type;Cells;Cessation of life;chemotherapy;Classification;Clinical;clinically relevant;Coculture Techniques;Consensus;cytokine;Cytokine Signaling;Cytotoxic Chemotherapy;Data;Data Set;Death Rate;Desmoplastic;Diabetes Mellitus;Diagnosis;Epithelium;Evolution;Exposure to;Family;Fibroblasts;fighting;gemcitabine;Gender;Gene Expression;Genetic Models;Genomic approach;Growth;Histology;Human;human old age (65+);IL6ST gene;Immune;Immune checkpoint inhibitor;Immunotherapy;implantation;Incidence;Interleukin-6;Intervention;Knowledge;LIF gene;Macrophage;male;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mesenchymal;Metabolic Pathway;Molecular;mortality;Motility;mouse model;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Nuclear Weapon;Obesity;oncostatin M;Operative Surgical Procedures;Outcome;overexpression;Paclitaxel;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Pathogenesis;Pathology;Patients;Persian Gulf;Phenotype;Prognosis;Proteins;Radiation;receptor;receptor expression;Receptor Signaling;Regimen;Research;response;Role;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smoking;Specimen;spheroids;stem cells;success;targeted treatment;Testing;Therapeutic;Therapeutic Studies;therapy resistant;treatment response;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Promotion;Veterans;virtual

PROJECT_TITLE: Oncostatin M Receptor in Pancreatic Adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Diffuse midline gliomas (DMGs) are devastating childhood brain tumors for which there are no effective therapies. I previously identified aberrant FOXR2 expression as a key driver event in DMG formation and growth, and that FOXR2 specifically activates ETS transcription factor circuits and is functionally redundant with growth factor receptor pathways. The work proposed here seeks to define the mechanisms by which FOXR2 cooperates with ETS transcription factors to drive MAPK signaling in FOXR2-expressing DMGs.

PI_NAMEs: TSAI, JESSICA WHEI (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Ablation;Advisory Committees;Animal Model;Area;Award;Base Sequence;Binding;Biological Assay;Biology;Brain Stem Glioma;cancer genomics;career;career development;Cell Proliferation;Cells;Childhood;Childhood Brain Neoplasm;Chromatin;Collaborations;Complex;CRISPR/Cas technology;Custom;Dana-Farber Cancer Institute;Data;diffuse midline glioma;Disease;DNA;DNA Binding;effective therapy;Electroporation;Environment;Epidermal Growth Factor Receptor;Epigenetic Process;epigenomics;ETV3 gene;Event;experience;Family member;forkhead protein;Genes;Genetic;Genetic Transcription;Genome;Genomics;Glioma;Gliomagenesis;Goals;Growth;Growth Factor Receptors;Histones;Immunoprecipitation;in utero;In Vitro;in vivo;in vivo evaluation;Institution;instructor;International;K-Series Research Career Programs;knock-down;Lead;Libraries;Malignant Childhood Neoplasm;MAP Kinase Gene;MAP2K1 gene;MAPK1 gene;MAPK3 gene;Mass Spectrum Analysis;Mediating;Mentors;Mentorship;Methods;Modeling;mouse model;Mus;Mutagenesis;mutant;Mutation;MYC Family Protein;neuro-oncology;Oncogenes;Oncogenic;Oncologist;Pathway interactions;Patient Care;PDGFRA gene;Pediatrics;Phenotype;phosphoproteomics;Physical assessment;Physicians;Proliferating;protein complex;protein protein interaction;Proteins;Proteomics;Receptor Signaling;Reporter;Reporting;Research;Research Personnel;Resources;Role;Scientist;Signal Transduction;skills;Testing;Time;TP53 gene;Training;transcription factor;transcriptomics;tumor;tumor initiation;tumorigenesis;Variant;Work

PROJECT_TITLE: Dissecting the cooperation of FOXR2 and ETS transcription factors in FOXR2-expressing diffuse midline gliomas

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE Osteochondral defects (OCDs) – damage to cartilage and underlying bone – leads to pain, loss of joint function and osteoarthritis. The goal of this research is to develop a bioprosthetic implant as an alternative to autografting and partial resurfacing treatments. The cylindrical implants would stimulate formation of new bone tissue and integration with host tissue while supplying synthetic cartilage necessary for joint function.

PI_NAMEs: GRUNLAN, MELISSA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Allografting;Area;Arthralgia;articular cartilage;Autologous Transplantation;base;Behavior;biodegradable scaffold;biomaterial compatibility;biomechanical test;Biomechanics;Bioprosthesis device;bone;Bone Regeneration;Bone Tissue;caprolactone;Cartilage;Cell Culture Techniques;Chondrocytes;Clinical;crosslink;Data;Defect;Degenerative polyarthritis;design;Deterioration;Devices;Electrostatics;Exhibits;Exposure to;fabrication;Femur;Generations;Geometry;Goals;Growth;healing;Histology;Human;Hydration status;Hydrogels;immunoreactivity;Implant;implantation;improved;In Vitro;in vivo;in vivo evaluation;Invaded;joint function;joint injury;Joints;Knee;knee replacement arthroplasty;Lactic acid;Lead;loss of function;Lubrication;mechanical properties;Medial;Memory;microCT;Modeling;Modulus;Morbidity - disease rate;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;osteochondral tissue;Osteogenesis;Pain;Pathologist;Performance;Polymers;Porosity;Property;Rattus;regeneration potential;regenerative;Reporting;Research;Resistance;response;Saline;scaffold;Shapes;Site;Slide;stem;subchondral bone;subcutaneous;substantia spongiosa;success;Surgeon;Techniques;Testing;tissue regeneration;Tissues;treatment group;ultra-high molecular weight polyethylene;Weight-Bearing state;Work

PROJECT_TITLE: Synthetic Cartilage-Capped, Regenerative Osteochondral Plugs to Heal Osteochondral Defects

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE This project assesses the effects of short-term air pollution exposure on lung function in a large national cohort of adults with a specific focus on effects in vulnerable populations, and also evaluates the use of a novel exposure assessment technique, nasosorption, for the development of novel biomarkers of air pollution exposure in at-risk populations. The proposed project has valuable public health implications, both in characterizing the effects of air pollution exposure in high-risk individuals and developing novel clinical tools to identify patients who are highly exposed to air pollution, with the ultimate goal of informing policy and clinical practice to mitigate the effects of these exposures in vulnerable groups.

PI_NAMEs: ZETLEN, HILARY LAURA (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acceleration;Acute;Address;Adolescence;Adult;Air;Air Pollutants;Air Pollution;airway inflammation;ambient air pollution;Area;Biological Markers;Biometry;Birth;Boston;Carbon Black;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical biomarkers;clinical epidemiology;clinical practice;cohort;Collaborations;Communities;community burden;community-level factor;Critical Care;Development;Diagnosis;Disparity;disparity reduction;Environment;Environmental Epidemiology;Environmental Health;environmental justice;eosinophilic inflammation;Epidemiologist;Epidemiology;experience;Exposure to;Fellowship Program;fine particles;Funding;Goals;Health;high risk;high risk population;Hospitalization;Impairment;Incidence;Individual;Inflammation;Inflammation Mediators;inflammatory marker;Inhalation Exposure;innovation;Iron;Israel;K-Series Research Career Programs;Knowledge;Lead;Liquid substance;Long-Term Effects;low socioeconomic status;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung health;marginalized population;Measures;Medical center;Mentors;Mentorship;Metals;Methodology;Methods;Morbidity - disease rate;mortality;Nasal Epithelium;Neighborhoods;neutrophil;Nickel;Nitrogen Dioxide;Nose;novel;novel marker;Outcome;Ozone;Participant;Patients;Persons;Physicians;Pilot Projects;Policies;Pollution;Populations at Risk;Principal Investigator;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonology;Research;Research Personnel;residence;respiratory;respiratory health;Respiratory Tract Infections;Rice;Risk;Risk Factors;Sampling;Schools;skills;Techniques;tool;traffic-related air pollution;Training;translational scientist;Upper respiratory tract;Vanadium;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Air pollution, biomarkers of exposure, and lung function in vulnerable populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The PRIDE is a mentored summer training experience in developing research skills for early career-stage faculty who are underrepresented in the biomedical sciences. The Coordination Center tracks indices of career success (e.g., grant awards) over time to determine if these mentored training programs lead to increasing the diversity among individuals engaged in health related research.

PI_NAMEs: FORAKER, RANDI E;RICE, TREVA K. (contact)

PROJECT_TERMS: Achievement;Address;Award;Benchmarking;Bioinformatics;career;Career Choice;career development;Censuses;cohort;Communication;comparison group;Data;data integration;Death Rate;Development;Disparity;disparity reduction;Diverse Workforce;diversity and inclusion;Education;education research;educational atmosphere;Educational workshop;Electronics;Equity;Evaluation;experience;Faculty;Fostering;Funding;Future;Goals;Grant;Health;Health Benefit;Heart Diseases;Hematological Disease;improved;indexing;Individual;Infrastructure;innovation;Lead;Lung Diseases;Measures;meetings;Mentors;Mentorship;Methodology;Methods;Minority;Mission;Morbidity - disease rate;Multicenter Studies;National Heart, Lung, and Blood Institute;Newsletter;Online Systems;Outcome;outreach;Participant;participant enrollment;Persons;Population;Positioning Attribute;Postdoctoral Fellow;Predisposition;Problem Solving;Procedures;Process;Program Evaluation;programs;Protocols documentation;racial disparity;racial diversity;racial health disparity;Records;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;response;Sampling;Science;Scientist;screening;Secure;Site;skill acquisition;skills;Sleep Disorders;success;summer institute;System;Time;tool;Training;Training and Education;Training Programs;Underrepresented Populations;Underserved Population;United States;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Coordination Center for Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Mutational variants in the trafficking receptor SORLA have been shown to be associated with increased Alzheimer’s disease (AD) risk. Although previous studies from our group and others have demonstrated roles for SORLA in both reducing Aβ accumulation, as well as mediating protective effects in response to Aβ, it remains unknown whether SORLA is also neuroprotective with respect to tau. Our proposed study here investigates whether SORLA upregulation also reduces toxic effects associated with tau, and potentially implicates SORLA in mediating protective effects from both fundamental pathologies (Aβ and tau) that define AD.

PI_NAMEs: HUANG, TIMOTHY YIKAI (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Affect;Age Months;aged;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analysis pipeline;animal old age;Animals;Astrocytes;astrogliosis;beta-site APP cleaving enzyme 1;Biological Assay;Brain;Bypass;Cell Nucleus;Cell surface;cell type;Cells;Complement;Complement 1q;CRISPR/Cas technology;dentate gyrus;Electrophysiology (science);Endosomes;entorhinal cortex;Epidermal Growth Factor Receptor;Functional disorder;gain of function;Gene Activation;Gene Expression Profile;Generations;Genes;Genetic;genetic signature;genome wide association study;glial activation;Gliosis;Golgi Apparatus;Hematopoietic stem cells;Hippocampus;Histologic;histological stains;Histology;Human;human embryonic stem cell;Immunoblot Analysis;Impairment;In Vitro;in vivo;insight;J20 mouse;Label;MAP Kinase Gene;Medial;Mediating;Microglia;Modeling;Mouse Strains;Mus;Mutation;N-terminal;Natural regeneration;Neurites;neuroinflammation;Neuronal Injury;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;postsynaptic;protective effect;Protein Isoforms;Proteins;Proteolysis;Proteolytic Processing;Proteomics;proteotoxicity;Publishing;Quantitative Reverse Transcriptase PCR;receptor;regenerative;Reporting;response;Risk Factors;risk variant;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;sortilin;Synapses;synaptic function;synaptic pruning;System;tau Proteins;tau-1;Toxic effect;trafficking;transcriptome sequencing;transcriptomics;Transgenic Organisms;Up-Regulation;uptake;Variant;Ventricular;virtual;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel Neuroprotective Roles for the Alzheimer's Disease Risk Gene SORLA in Tau Pathology and Pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Social Determinants of Health

ORG_CITY: TUSCALOOSA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Salla disease is a rare lysosomal storage disorder linked to heritable autosomal recessive mutations in the human SLC17A5 gene, encoding a transporter protein on the membrane of lysosomes that is needed for export of recycled sugar molecules used in glycoprotein and glycolipid formation. Studies have been limited in scope due to the premature lethality associated with mutations in SLC17A5 that result in an acute accumulation of sugars within the lysosome and cause a severe infantile sialic acid storage disorder (ISSD), whereas Salla disease is characterized by weaker mutations that result in a more slowly progressive adult form of neurodegenerative disease. Here we will develop a new animal model of Salla disease that circumvents the lethality of ISSD and other models through use of genetic and pharmacological combinations designed to uncover neuromodulators of SLC17A5 and enable the examination of two primary symptoms – convulsions and progressive neurodegeneration, to accelerate the path of therapeutic discovery for adults with this rare disorder.

PI_NAMEs: CALDWELL, GUY A (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Age;Aging;alpha synuclein;Amino Acids;Animal Model;Animals;associated symptom;Ataxia;autosome;Behavior;Biological Assay;Biological Models;C. elegans genome;Caenorhabditis elegans;Carrier Proteins;CCL21 gene;Cell membrane;Cell model;Charge;chemical genetics;cholinergic;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Convulsions;Coupled;course development;Databases;design;Disease;dopaminergic neuron;drug action;early childhood;Epilepsy;Equation;Exhibits;experience;Experimental Models;Finnish Type Sialic Acid Storage Disease;Functional disorder;gene product;Genes;Genetic;genetic analysis;genetic approach;Genetic Crosses;Genetic Induction;Glucuronic Acids;Glycolipids;Glycoproteins;Goals;Heritability;high reward;high risk;Human;Hydrolysis;Impairment;Incentives;Individual;infancy;Infantile Form Sialuria;Intellectual functioning disability;Invertebrates;Investigation;knockout animal;Knockout Mice;Link;lysosome membrane;Lysosomes;marginalization;Membrane Proteins;model development;model organism;Modeling;Molecular;Mus;Muscle hypotonia;mutant;Mutation;Names;Nature;Nematoda;Nerve Degeneration;Nervous System;neural;Neurodegenerative Disorders;Neuromodulator;neuronal excitability;neuronal survival;Neurons;neuroprotection;neuroregulation;neurotoxic;Organelles;Orphan Drugs;Orthologous Gene;overexpression;Pathogenicity;Patients;pharmacologic;Phenotype;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;Predisposition;premature;progressive neurodegeneration;Proteins;Protons;Rare Diseases;Recycling;Research;Risk;Role;screening;Sialic Acids;solute;Statutes and Laws;sugar;Surveys;symporter;Symptoms;Therapeutic;Transgenic Animals;United States;United States National Institutes of Health;Variant

PROJECT_TITLE: Phenotypic Analysis of SLC17A5 Neuromodulation in Salla Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Telehealth

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Improvements following behavioral parent training for childhood ADHD are attenuated significantly when parents also experience high levels of ADHD symptoms, and parental ADHD poses a significant barrier to successful application of the parenting skills learned during treatment. The proposed project will design and preliminarily test a behavioral parenting program that integrates (a) CBT strategies for parental ADHD symptoms and (b) an mHealth adjunct app providing timely, personalized reminders and CBT-based supports to improve in vivo parenting skill use. By reducing barriers to skill use due to parental ADHD, this study has considerable potential to improve child outcomes and reduce the significant personal and public health costs associated with the disorder.

PI_NAMEs: FRIEDMAN, LAUREN MELISSA (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Aftercare;Attention;Attention deficit hyperactivity disorder;Attenuated;Behavior Therapy;Behavioral;career;caregiver education;Child;Child Rearing;Childhood;Cognitive Therapy;Data;design;Development;Diagnosis;digital health;Disease;Ecological momentary assessment;Educational process of instructing;effective intervention;Etiology;Evaluation;evidence base;Evidence based intervention;Executive Dysfunction;executive function;experience;Family;Feedback;Focus Groups;forgetting;Foundations;Goals;Health Care Costs;human centered design;Impairment;implementation science;improved;in vivo;interest;intergenerational;Intervention;Interview;Investigational Therapies;K-Series Research Career Programs;Learning;Learning Skill;Life;Measures;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mHealth;Mobile Health Application;Motivation;multimodality;Outcome;parenting intervention;Parents;Performance;Policies;Population;Positioning Attribute;prototype;Public Health;Reporting;Research;Research Personnel;Risk Factors;School-Age Population;skills;skills training;smartphone application;social learning;Stress;Subgroup;success;successful intervention;Symptoms;Testing;theories;Therapeutic Intervention;therapy design;therapy development;tool;Training;Training Programs;treatment adherence;treatment effect;Treatment outcome;treatment research;United States National Institutes of Health;usability;Work;X Inactivation;Youth

PROJECT_TITLE: Enhancing behavioral parent training for parents and children affected by ADHD

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Transplantation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Immunotherapy with T cells expressing so called chimeric antigen receptors (CARs) that target CD19 (CD19- CAR T cells) has been very effective for pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL). However, only approximately half of patients benefit from this approach long term. In this proposal, we aim to overcome current limitations of CD19-CAR T-cell therapy by generating these CAR T-cells from healthy donors and enhancing their anti-leukemia activity by additional genetic modifications.

PI_NAMEs: TALLEUR, AIMEE C. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 21 year old;Address;Allogenic;Antigen Targeting;Antigens;antileukemic activity;Area;Autologous;Award;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Biological Assay;Biometry;burden of illness;CAR T cell therapy;career;career development;CD19 gene;CD22 gene;Cell Count;Cell Therapy;Cellular biology;Characteristics;chemotherapy;Childhood Precursor B Lymphoblastic Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical investigation;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Correlative Study;CRISPR/Cas technology;cytokine;Data;Dedications;design;Development;Development Plans;Disease;Disease remission;disorder risk;DNMT3a;Donor Lymphocyte Infusion;Dose;Educational workshop;efficacy evaluation;Epigenetic Process;epigenetic profiling;Evaluation;exhaustion;experience;Failure;fitness;Frequencies;Future;Gene Modified;Genes;Genetic;Goals;graft vs host disease;Grant;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Immunology;Immunotherapy;improved;in vivo;Infusion procedures;insight;investigator-initiated trial;Knock-out;Knowledge;Lead;Leadership;leukemia;Lymphocyte Count;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mentors;Mentorship;minimal risk;Modification;Molecular Analysis;next generation;novel;novel strategies;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Phase;phase 1 study;Phase I Clinical Trials;Phenotype;pre-clinical;Pre-Clinical Model;Prevention;Prior Chemotherapy;Production;programs;Proliferating;Refractory;Relapse;relapse patients;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Proposals;Risk;risk minimization;Safety;Severities;single-cell RNA sequencing;skills;Structure;T memory cell;T-Lymphocyte;Technology;Testing;Therapeutic;therapy design;Time;Training;Translating;Translations;tumor;Tumor Burden;Variant;Work;Writing

PROJECT_TITLE: Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Physical Activity;Prevention;Primary Health Care

PHR: PROJECT NARRATIVE The focus of this research is the understanding of the role of mind-body exercises and related integrative approaches in healthcare and how these multi-dimensional therapies can be helpful in supporting positive health behaviors, such as physical activity. This is a renewal application that will provide continued support for the candidate to mentor the next generation of scientists in the field of integrative medicine and whole person health.

PI_NAMEs: YEH, GLORIA Y (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Area;Award;behavior change;Benchmarking;Cardiopulmonary;Cardiovascular system;career;career development;catalyst;Chronic;Chronic Disease;Chronic lung disease;Clinical;clinical efficacy;Clinical Research;Collaborations;Complementary Health;Congresses;Continuing Education;Creativeness;Data Collection;Dedications;Dimensions;Education;education research;education resources;eHealth;Engineering;Environment;Exercise;exercise intervention;experience;Faculty;Fellowship;fitness;Funding;Future;Grant;Health behavior;Health Priorities;Healthcare;Hospitals;implementation research;Individual;innovation;Institution;Integrative Medicine;International;Intervention;intervention delivery;Israel;K-Series Research Career Programs;Knowledge;Leadership;Learning;Lung;Measures;Medical center;medical schools;Mentors;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);Mind-Body Intervention;Mind-Body Method;mind/body;Movement;multimodality;National Center for Complementary and Integrative Health;next generation;Outcome;patient oriented research;Patients;Physical activity;Population;Postdoctoral Fellow;Primary Care Physician;primary care practice;Principal Investigator;programs;psychosocial;Publications;remote delivery;remote technology;Research;research facility;Research Personnel;Role;Science;Scientist;skills;Solid;success;supportive environment;Time;Training;Training and Education;training opportunity;United States National Institutes of Health;wearable device;whole health

PROJECT_TITLE: Mentoring and Patient-Oriented Research in Integrative Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Metabolic syndrome (MetS), insulin resistance (IR), and type-2 diabetes mellitus (T2DM) increase the risk of developing Alzheimer’s disease (AD), and Alzheimer’s disease related dementias (ADRD), and AD pathology worsens MetS/IR/T2DM pathobiology. To investigate the underlying mechanisms whereby MetS/IR contributes to AD/ADRD pathology and vascular dementia, we utilize a nonhuman primate (NHP) model of MetS/IR, dyslipidemia, T2DM, and systemic inflammation resulting from consumption of a high sugar diet (HSD) in order to address the scientific premise that MetS/IR/T2DM exacerbates molecular and cellular changes within the brain that promote pathogenesis of AD/ADRD which we will rigorously investigate in peripheral metabolic pathways and vulnerable hippocampal, cortical, and hypothalamic circuits, and cerebrovasculature via coordinated immunochemical, histopathologic, proteomic, and transcriptomic studies along with associated biobehavioral assessments and advanced imaging approaches. By addressing our hypothesis that the HSD initiates a vicious cycle between mechanisms underlying neurodegeneration and diabetes pathogenesis that result in the progression of both diseases, and whereby neuropathology is exacerbated by MetS/IR/T2DM, while impaired brain control of glucose and lipid homeostasis leads to a worsening progression towards T2DM, this proposal will provide novel information regarding mechanisms involved in these interactions and will lead to new and better targeted therapeutic interventions.

PI_NAMEs: GINSBERG, STEPHEN D;HAVEL, PETER J (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;Address;adiponectin;Adipose tissue;Adult;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animals;Anti-Inflammatory Agents;Architecture;Behavior;Behavioral;behavioral outcome;biobehavior;Biochemical;Blood - brain barrier anatomy;Blood Glucose;blood glucose regulation;Blood Vessels;blood-brain barrier function;Brain;brain control;brain dysfunction;Brain region;Cerebellum;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Characteristics;Clinical;cognitive performance;cohort;Consumption;cytokine;Data;Data Set;Dementia;dementia risk;design;Development;Diabetes Mellitus;diabetes pathogenesis;Diet;dietary control;Disease;Disease Progression;Dyslipidemias;Endocrine;endoplasmic reticulum stress;Epidemiology;Evaluation;executive function;experience;Experimental Designs;Functional disorder;Glucose;Hippocampus;Homeostasis;Hormones;Human;Hypothalamic structure;Image;imaging approach;Immunologics;Impaired cognition;Impairment;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Insulin Resistance;insulin signaling;Insulin Signaling Pathway;Investigation;Link;Lipids;Liver;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Memory;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Muscle;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peripheral;Persons;Pharmacology;Positron-Emission Tomography;prognostic;Proteomics;recruit;Research;Risk;Signal Pathway;sugar;Synapses;systemic inflammatory response;targeted treatment;tau Proteins;tau-1;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;Translating;Vascular Dementia;Vascular Diseases

PROJECT_TITLE: Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lupus;Patient Safety

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative This mid-career investigator award will support a program in patient-oriented research in rheumatic diseases at the University of California, San Francisco. The award will allow the applicant to expand her research on the development and validation of health care quality measures and will support her mentoring of early investigators. The proposed research aims to develop tools that will facilitate measuring and improving the quality of care for lupus, a condition where gaps in quality of care and health disparities are well-documented.

PI_NAMEs: YAZDANY, JINOOS  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;American;Area;Award;Back;California;career;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical Data;clinical practice;Clinical Research;Clinical Trials;Collection;college;Communities;Consensus;Consolidated Framework for Implementation Research;Country;Data;data dashboard;data registry;Development;Disease;Disparity;Dissemination and Implementation;Dose;Electronic Health Record;Eligibility Determination;Environment;Equity;Feeds;Focus Groups;Food and Drug Administration Drug Approval;Funding;Glucocorticoids;Health;health care disparity;health care quality;health disparity;Healthcare;Healthcare Systems;human centered design;Hydroxychloroquine;implementation measures;implementation science;improved;improved outcome;Individual;Infrastructure;innovation;Institution;interest;Interview;Kidney;Kidney Diseases;Knowledge;Lupus;Measurement;Measures;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Monitor;novel strategies;Outcome;Outcome Measure;patient oriented;patient oriented research;Patient Outcomes Assessments;Patients;payment;Performance;Persons;Physicians;Population;practice setting;Process;programs;Public Health;Qualifying;Qualitative Methods;Quality of Care;Reaction;Regimen;Registries;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Rheumatism;rheumatologist;Rheumatology;Sampling;San Francisco;Source;Structure;Systemic Lupus Erythematosus;theories;Time;tool;United States;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Universities;Validation;Validity and Reliability;Variant;Visit;Work

PROJECT_TITLE: Advancing Quality and Outcomes Measurement in Rheumatology

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease

PHR: Project Narrative Development of a diverse biomedical research workforce is critical to address health disparities among underrepresented minority racial and ethnic groups. This renewal of the Washington University PRIDE CVD- CGE program proposes state-of-the-art approaches to research training in cardiovascular disease epidemiology, comorbidities, genetic epidemiology, implementation science, and data science and bioinformatics. Mentored early stage investigators are more likely to succeed in their research efforts and be retained in academia.

PI_NAMEs: DAVILA-ROMAN, VICTOR G. (contact);DE LAS FUENTES, LISA ;RAO, DABEERU C

PROJECT_TERMS: Academia;Address;Applications Grants;Area;Bioinformatics;Biomedical Research;Cardiovascular Diseases;cardiovascular disorder epidemiology;career;career development;cohort;Collaborations;comorbidity;Creativeness;Critiques;Data;Data Science;Development;Development Plans;effectiveness evaluation;Elements;Enrollment;Epidemiology;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Faculty Recruitment;Feedback;follow-up;Funding;Funding Opportunities;Genetic;genetic epidemiology;global health;Goals;Grant;Grant Review Process;health disparity;Home;Hybrids;implementation science;Individual;innovation;Institution;Knowledge;Leadership;low and middle-income countries;Manuscripts;Measures;meetings;Mentors;mid-career faculty;Minority Groups;Mission;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Participant;peer coaching;Persons;programs;Publications;Publishing;racial population;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Research Training;Scholarship;Secure;senior faculty;Site;skills;Study Section;success;summer institute;Time;Training;Training Activity;Underrepresented Minority;United States National Institutes of Health;Universities;Update;virtual;Washington;Writing

PROJECT_TITLE: PRIDE Summer Institute in Cardiovascular Disease Comorbidities, Genetics and Epidemiology (CVD-CGE)


NIH_SPENDING_CATS: Cardiovascular;Foodborne Illness;Genetics;Heart Disease;Human Genome;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Arsenic exposure is associated with increased risk of cardiovascular disease, and this relationship may be modified by arsenic methylation, a biological pathway that decreases arsenic toxicity and increases excretion of arsenic in urine. This study will identify pre- and post-transcriptional gene regulatory factors involved in arsenic methylation efficiency and arsenic-related cardiovascular disease risk among Native American adults. Findings will provide insight to the pathways that link arsenic to complex health outcomes, support the development of biomarkers of arsenic-related cardiovascular disease, and help target public health interventions.

PI_NAMEs: BOZACK, ANNE KRISTINA (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adult;anthropogenesis;Applied Skills;Arsenic;Arsenicals;Bioinformatics;Biological;Biological Factors;Biological Markers;biomarker development;biomarker validation;Biometry;burden of chronic illness;candidate identification;carcinogenicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;circulating microRNA;Cluster Analysis;cohort;Cohort Studies;Complex;Data;Development;Disease;Disease Outcome;disorder risk;DNA Methylation;DNA Methylation Regulation;drinking water;Environmental Epidemiology;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome-wide association studies;Ethnic Population;Etiology;Excretory function;Face;Family Study;Foundations;gene interaction;Genes;Genetic;genetic epidemiology;Genetic Transcription;Genetic Variation;Health;Heart;Hepatic;high dimensionality;Incidence;Individual;Ingestion;insight;Link;Machine Learning;machine learning method;Measures;Mediating;Mediation;Mediator;Mentorship;Messenger RNA;Methods;Methylation;methylation biomarker;microRNA biomarkers;MicroRNAs;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Native American community;Native Americans;Outcome;Pathway Analysis;Pathway interactions;Phase;Phenotype;Population;Post-Transcriptional Regulation;posttranscriptional;Privatization;Process;prospective;Public Health;public health intervention;Quantitative Trait Loci;recruit;Regulation;Research;Research Personnel;Risk;Role;rural Americans;rural residence;Signal Transduction;Testing;Toxic effect;Toxin;Training;United States;urinary;Urine;Work

PROJECT_TITLE: Epigenetic and genetic regulation of arsenic methylation and arsenic-relatedcardiovascular disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (K9)]