NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The project will identify the optimal intermittent vibration force stimulation to control orthodontic tooth movement rate through a rat study and scale it up for other species, including dogs and humans. The relevance of this project is that, once successful, the technology will enable clinicians to shorten the treatment time with reduced side-effects. The long term goal is to translate this technology into devices that can be used c linic ally.

PI_NAMEs: CHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acceleration;Ally;alveolar bone;Animals;Biological;Biomechanics;bone;Bone Density;Canis familiaris;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Devices;Dose;Elements;Ensure;Frequencies;Future;Goals;Human;Iatrogenesis;Individual;Investigation;Litigation;Mature Bone;Mediating;Methods;Modeling;Movement;new technology;novel;Orthodontic;Orthodontic Appliances;Outcome;Patients;Pattern;Periodontal Ligament;Phase;Positioning Attribute;Rattus;Reaction;Relapse;relapse prevention;Reporting;response;Root Resorption;scale up;side effect;Specific qualifier value;Stress;System;Technology;Testing;theories;Time;Tooth Movement;Tooth structure;Translating;vibration;Work

PROJECT_TITLE: Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: The accurate repair of DNA double-strand breaks is critical for viability in all organisms. Repair mechanisms that rely on DNA synthesis initiated by broken ends were previously thought to compete with mechanisms that join ends independently of sequence homology, but our data shows that these are actually sequential, linked processes. This proposal investigates the coordination between these pathways of double-strand break repair in human cells to understand how this affects the processing of ends during the cell cycle, how this process works globally across the genome, and how the complexes involved in this coordination work at a mechanistic level.

PI_NAMEs: PAULL, TANYA T (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Agreement;Aspergillus Nuclease S1;Binding;Biochemistry;Biological Assay;C-terminal;Cell Cycle;Cell Cycle Regulation;Cells;Characteristics;chromatin immunoprecipitation;Chromosomal Rearrangement;Chromosome Deletion;Collaborations;Collecting Cell;Complex;crosslink;Cyclin-Dependent Kinases;Cytolysis;Data;DNA;DNA analysis;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA-dependent protein kinase;DNA-PKcs;Double Strand Break Repair;Electron Microscopy;Enzyme Induction;Eukaryota;Event;Excision;experimental study;G1 Phase;G2 Phase;G22P1 gene;Genome;Goals;homologous recombination;Human;In Vitro;in vitro activity;inhibitor;Ligation;Link;Mammalian Cell;Mass Spectrum Analysis;Mediating;Methods;Modeling;Modification;Molecular Conformation;Monitor;next generation sequencing;Nonhomologous DNA End Joining;novel;nuclease;Organism;Outcome;Pathway interactions;Pattern;Phase;Phosphorylation;Phosphorylation Site;Physiological;Play;Procedures;Process;Production;protein complex;protein kinase inhibitor;Proteins;Recombinant Proteins;Recombinants;Recovery;recruit;Regulation;Repair Complex;repaired;Resected;restriction enzyme;Role;S phase;Sequence Homology;Series;single molecule;Single-Stranded DNA;Site;structural biology;Structure;Testing;Work;XRCC5 gene

PROJECT_TITLE: DNA end processing by the Mre11/Rad50/Nbs1 complex in human cells

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Majority of the patients with aggressive prostate cancer develop resistance to therapy and the tumor metastasizes to bones and other visceral organs accounting for high morbidity and mortality. The goal of this project is to define the underlying mechanisms that promote the survival and colonization of prostate tumor cells in the bone microenvironment. Our study will uncover molecular links between mitochondrial metabolism and transcriptional regulation that enables PCa adaptation, survival and ultimately metastatic competency.

PI_NAMEs: DASGUPTA, SUBHAMOY  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Ablation;Accounting;Acetylation;Aconitate Hydratase;Advanced Development;advanced disease;advanced prostate cancer;Anabolism;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Automobile Driving;Binding;Bioenergetics;bone;Cancer Patient;cancer survival;Carbon;Castration;Cell Nucleus;Citrates;Clinical;Communication;Competence;Data;Deacetylase;Dependence;Disease;enzyme activity;Enzymes;Event;fatty acid biosynthesis;Fatty acid glycerol esters;Fatty Acids;gene repression;gene synthesis;Genes;Genetic;genetic corepressor;Genetic Transcription;Glutamine;Goals;GRIP1 gene;Growth;Homing;Hormones;Human;in vivo;Link;lipid biosynthesis;Lipids;loss of function;Lysine;Malignant neoplasm of prostate;Mediating;men;Metabolic;Metabolic stress;Metabolism;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;mimetics;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;NCOA2 gene;Neoplasm Metastasis;novel;Nuclear;Nuclear Receptors;Oncogenic;Organ;Organelles;Pathogenesis;Pathway interactions;Patients;Physiological;Play;Primary Lesion;programs;promoter;Property;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostatic Neoplasms;Proteins;Recurrence;Refractory;Relapse;Repression;Resistance development;restoration;Role;Signal Transduction;Sirtuins;steroid hormone receptor;Steroid Receptors;Therapeutic;therapy resistant;Transcriptional Activation;Transcriptional Regulation;tumor;Tumor Suppressor Proteins;Visceral

PROJECT_TITLE: Mechanisms of metabolic stress-induced transcriptional regulation in prostate cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PI_NAMEs: AMEREDES, BILL T (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Academy;Address;Administrator;Biometry;career development;Clinical;Clinical Investigator;Clinical Research;Collaborations;Community Developments;community engagement;Competence;Development;Development Plans;early-career faculty;Education;Educational Activities;Entrepreneurship;experience;externship;Faculty;Financial Support;Fostering;Functional disorder;Funding;Future;graduate student;Hispanic;Human;Individual;Informatics;innovation;Institution;Leadership;leadership development;Link;medical schools;member;Mentors;Mentorship;novel;Peer Group;Positioning Attribute;Production;program dissemination;programs;prospective;recruit;Research;Research Design;Research Personnel;Scholars Program;Science;student training;success;Texas;TNFSF15 gene;Training;Training and Education;translational medicine;Translational Research;translational scientist;Underrepresented Minority;Writing

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Millions of women in the United States (US) face gaps and transitions (disruptions) in insurance coverage during the preconception, pregnancy, and postpartum periods, which has led to recent state- and federal- legislation proposing perinatal insurance eligibility expansions as a solution for addressing preventable maternal morbidity and mortality in the US. We lack an understanding, however, of 1) the associations between maternal insurance disruptions and maternal and child health (MCH) outcomes and 2) whether prior perinatal insurance expansions have been associated with improved MCH outcomes. Correcting these knowledge gaps is the overarching goal of this proposal, data which we believe will be of great public health importance and inform clinical and policy strategies for improving maternal health in the US.

PI_NAMEs: ADMON, LINDSAY KENNEDY (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Understanding the impact of perinatal insurance disruptions on maternal and child health outcomes

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: PTSD is a serious psychiatric concern for our Veteran population and the VA is highly motivated to address our current gaps in understanding regarding the biological underpinnings of stress response to traumatic experiences. Leveraging advancements in genetics and brain functioning research may be an important path in improving this understanding. This proposal looks to use publicly available datasets and empirically derived biological markers for PTSD. We provide evidence this approach could help in diagnosing PTSD, as well as uncovering different types of PTSD based on genetic and brain data. This work could pave the way for algorithmically determining care, or provide a foundation for developing tailored care for types of PTSD.

PI_NAMEs: SIMMONS, ALAN N (contact)

PROJECT_TERMS: Acceleration;Address;advanced analytics;Algorithms;Amygdaloid structure;analytical tool;Behavioral;Biological;biological adaptation to stress;Biological Markers;Brain;Caring;Chromosome Mapping;Classification;Clinical;clinical care;Cognition;Collection;comorbidity;Complex;cost;Data;data repository;Data Set;deep learning model;density;Development;Diagnosis;Diagnostic and Statistical Manual of Mental Disorders;Dimensions;Disease;DNA analysis;Evaluation;experience;feature selection;Formulation;Foundations;Gene Combinations;Genetic;genetic analysis;genetic predictors;genome wide association study;Grant;Graph;Grouping;Heterogeneity;improved;Individual;individualized medicine;Lead;Link;Literature;Machine Learning;Maps;Measurement;Measures;Methodology;Methods;military veteran;Modeling;Neurobiology;neuroimaging;neuroimaging marker;novel;personalized medicine;Persons;polygenic risk score;Population;Post-Traumatic Stress Disorders;programs;Reporting;repository;Research;research and development;response;Sampling;self organization;Subgroup;success;Symptoms;Techniques;Testing;therapy development;Training;traumatic event;traumatic stress;Trees;Validation;Veterans;Work

PROJECT_TITLE: Biomarker based classification and clustering of Veterans with PTSD


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed research is highly relevant to public health and NIH’s mission because transcription-coupled nucleotide excision repair (TC-NER) is an important pathway for removing harmful DNA lesions in the transcribed genome and a critical drug target pathway for anticancer chemotherapy. Mutations in TC-NER proteins cause several human diseases including Cockayne Syndrome, Cerebro-Oculo-Facio-Skeletal Syndrome, and Ultraviolet–Sensitive Syndrome. The new knowledge obtained from proposed research will provide novel mechanistic insights into TC-NER as well as a framework for developing novel TC-NER targeting therapeutics against cancer and other human diseases.

PI_NAMEs: WANG, DONG  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;anti-cancer;Area;Biochemistry;Cellular biology;Cerebrooculofacioskeletal Syndrome;Chemotherapy-Oncologic Procedure;Cockayne Syndrome;Collaborations;Complex;Computational Biology;Cryoelectron Microscopy;Data;Defect;DNA;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;Drug Targeting;Elongation Factor;environmental agent;Funding;Genetic;Genetic Transcription;Genome;genome integrity;Genomics;Goals;Grant;human disease;Hybrids;innovation;insight;Knowledge;Lesion;Malignant Neoplasms;Methods;Mission;Modeling;Molecular;Mutation;novel;Oligonucleotides;Orthologous Gene;Paper;Pathway interactions;Peer Review;Play;Polymerase;Process;protein complex;protein function;Proteins;Prothrombin;Public Health;reconstitution;recruit;repair enzyme;repaired;Reporting;Research;RNA Polymerase II;Role;Site;structural biology;Structure;success;Surgical incisions;Syndrome;System;targeted treatment;Testing;Transcription Elongation;transcription factor S-II;transcription factor TFIIH;Transcription Initiation;Transcription Repressor;Transcription-Coupled Repair;translocase;ultraviolet;United States National Institutes of Health;X-Ray Crystallography;Xeroderma Pigmentosum;Yeasts

PROJECT_TITLE: Molecular Mechanisms for DNA Damage Processing by Transcription Machinery

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This project investigates the daily and long-term patterns of mental health outcomes among Hispanic and Latinx (H&L) caregivers of individuals with Alzheimer’s disease and related dementias (ADRDs). Using a multi-time scale design consisting of daily diary surveys and longer, traditional questionnaires, we will examine interactions between contextual, individual-level, and cultural factors that impact mental health trajectories over time. The results from this project will identify modifiable targets that improve resilience and inform ecologically and culturally relevant interventions to support H&L caregivers, an ethnically and racially underrepresented population in the field of aging.

PI_NAMEs: PUGA, FRANK  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acculturation;Address;Admission activity;Affect;Aging;Alzheimer's disease related dementia;Anxiety;anxiety symptoms;Automobile Driving;Behavioral;Behavioral Symptoms;Caregivers;caregiving;clinically significant;Cross-Cultural Comparison;daily functioning;Dementia;Dementia caregivers;depressive symptoms;design;Development;diaries;disability;Distal;Enrollment;ethnic diversity;Ethnic Origin;experience;Family Caregiver;Funding;Health;Health Disparities Research;high risk;Hispanic;Hispanic Populations;Impairment;Individual;Individual Differences;individual variation;informal caregiving;innovation;Integrative Therapy;Intervention;Investigation;Knowledge;Latinx;Latinx population;Link;Masks;Measures;Mental Depression;Mental Health;Modeling;multilevel analysis;Not Hispanic or Latino;Nursing Homes;older adult;Outcome;Participant;Pattern;peer;persistent symptom;Personal Satisfaction;Persons;poor health outcome;Population;Process;promote resilience;protective factors;psychologic;Psychopathology;Questionnaires;Race;racial diversity;Reporting;Research;Research Design;resilience;Risk;Risk Reduction;Sampling;Severities;social culture;sociocultural determinant;Stress;stressor;Surveys;Symptom Burden;Symptoms;Testing;theories;Time;Underrepresented Populations;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Mental Health Experiences of Hispanic and Latinx ADRD Caregivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Narrative The project uses a simple cyanobacterial model system to ask questions that cannot be addressed as directly in animals about how the circadian biological clock keeps time, stays synchronized with the environment, and contributes to the well-being of an organism. Circadian dysfunction contributes to a range of disease states in humans, from metabolic syndrome to mental illness. Past discoveries using this system have revealed fundamentally new paradigms of protein biochemistry with relevance for diverse organisms, including humans and pathogens.

PI_NAMEs: GOLDEN, SUSAN S (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Anacystisnidulans;Animals;Bar Codes;Binding;Biochemical;Biological;Biological Assay;Biological Clocks;Biological Models;Biological Rhythm;Biotechnology;Cardiovascular Diseases;Cell Physiology;Cells;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clock protein;Complex;Cryo-electron tomography;Cues;Cyanobacterium;Cytology;Disease;Environment;Escherichia coli;Eukaryota;Event;experimental study;fitness;Functional disorder;Genes;Genetic;Genomics;Growth;Health;Human;In Vitro;Ions;Libraries;Malignant Neoplasms;Mammals;Mediating;Mental disorders;Metabolic;Metabolic syndrome;Metabolism;model organism;Modeling;Molecular;Nucleotides;Organism;pathogen;Personal Satisfaction;Phase;Phenotype;Phosphotransferases;Phylogenetic Analysis;Physiological;Physiology;Preparation;Production;Prokaryotic Cells;promoter;Property;Protein Biochemistry;Proteins;reconstitution;Regulation;Resolution;Sasa;Signal Transduction;Site;Sleep Disorders;System;Time;transcription factor;Trees;Visualization;Work

PROJECT_TITLE: Molecular and cellular mechanisms of circadian timekeeping in a prokaryote model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: IRVINE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Child maltreatment is widely recognized as a serious threat to children's well-being and health, and in these cases, the fidelity of the child victim/witness's report is often crucial to securing an outcome in the best interest of the child. There is current debate and a pressing need to identify strategies for obtaining information about time passage and event sequence – elements critical to a child's perceived credibility. We propose to examine (1) how children are questioned, and respond about, event sequence in maltreatment investigations, (2) how differences in children's age, comprehension, attention, executive functioning skills, and memory may impact their ability to accurately report event sequence when prompted with the identified question types, and (3) how questions and child responses regarding event sequence impact mock juror comprehension and decision-making relevant to child maltreatment cases.

PI_NAMEs: KLEMFUSS, JESSICA ZOE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 12 year old;Adult;Age;age difference;Attention;Caregivers;Child;Child Abuse and Neglect;child protective service;Child Welfare;Code;Cognition;Cognitive;cognitive development;cognitive load;cognitive testing;Comprehension;Confusion;contextual factors;convict;Data;Decision Making;Development;Diagnostic;Dimensions;Disclosure;discount;Education;effectiveness testing;Elements;Eligibility Determination;Empirical Research;Episodic memory;Event;executive function;expectation;experience;experimental study;Failure;Foundations;Goals;Guidelines;Health;improved;innovation;interest;Interview;Investigation;Knowledge;Laboratories;Laboratory Study;Lead;Legal;Light;Linguistics;Literature;maltreatment;member;Memory;Mental Health;Outcome;Participant;physical conditioning;Positioning Attribute;psychologic;Reporting;Research;Respondent;response;Risk;Role;Sampling;Secure;Short-Term Memory;skills;stem;Testing;Time;Transcript;Work

PROJECT_TITLE: Children's Comprehension and Memory of Event Sequences and Its Implications for Maltreatment Disclosure

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

PHR: Project Narrative Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is termed a cardiac “disease of the desmosome”; however, the mechanisms through which desmosomal mutations drive ARVD/C remain unclear. Proposed studies are aimed to dissect mechanisms by which desmosomal mutations in RNA splicing drive ARVD/C, as well as targeted gene therapy and mutation corrective strategies to alter ARVD/C disease course.

PI_NAMEs: SHEIKH, FARAH  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adherens Junction;Adult;Age;arrhythmogenic cardiomyopathy;Arrhythmogenic Right Ventricular Dysplasia;base;base editing;base editor;Biological Assay;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Complex;Connexins;CRISPR/Cas technology;Data;Defect;design;Desmosomes;Disease;disease-causing mutation;Dose;Electrophysiology (science);Exhibits;Gene Mutation;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;Genome;Genomics;Heart;Heart Diseases;Human;human disease;human induced pluripotent stem cells;human model;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;Intercellular Junctions;Intervention;Knock-in Mouse;Life;man;Mechanics;Mediating;Methods;Modeling;Molecular;Molecular Target;Molecular Weight;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutate;Mutation;mutation correction;Neonatal;neonatal mice;novel;Pathogenesis;Pathogenicity;Patients;Physiological;plakophilin 2;prevent;prime editing;prime editor;Protein Analysis;protein complex;protein degradation;Proteins;restoration;RNA;RNA analysis;RNA Splicing;RNA Stability;RNA-Binding Proteins;scaffold;Splice-Site Mutation;Sudden Death;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;Transcript;transcriptomics;Viral;young adult

PROJECT_TITLE: Uncovering Molecular Targets for Arrhythmogenic Cardiomyopathy Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-Q(02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Import of the viral DNA to the nucleus of target cells is an essential, and vulnerable step in the HIV-1 life cycle. This project will investigate the mechanistic basis for the inhibition of HIV-1 nuclear import by Mx2 and the effects of Mx2 activity on viral susceptibility to other innate immune effectors. Understanding the molecular details of these interactions may provide new opportunities for the development of novel therapeutics for HIV-1 infection.

PI_NAMEs: KANE, MELISSA E (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Affect;Amino Acid Sequence;Anti-viral Agents;Binding Proteins;Capsid;Capsid Proteins;Cell Cycle;Cell Line;Cell Nucleus;cell type;Cells;Chimeric Proteins;cofactor;Complex;Dependence;Development;DNA;Event;Genome;Guanosine Triphosphate Phosphohydrolases;Heterogeneity;HIV Infections;HIV-1;Immune;Importins;Individual;Infection;Innate Immune Response;Innate Immune System;insight;Interferons;Interphase Cell;Investigation;knock-down;Length;Lentivirus;Life Cycle Stages;Mediating;Modeling;Molecular;mutant;N-terminal;novel therapeutics;Nuclear;Nuclear Import;Nuclear Localization Signal;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleic acid detection;Outcome;Pathway interactions;Pattern recognition receptor;Predisposition;Primate Lentiviruses;Process;protein protein interaction;Proteins;Reporting;response;Role;sensor;Signal Transduction;Testing;trafficking;TRIM Gene;Viral;viral DNA;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Inhibition of lentiviral nuclear import pathways by Mx2

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE A central challenge in biology is to understand the genetic basis of complex traits, including those relevant for human health. Genes underlying human metabolic disorders show variation that correlates with climate, suggesting a link between environmental adaptation and disease. Mice are the premier model for humans, and the proposed work will describe the genetic basis of complex traits underlying environmental adaptation in mice.

PI_NAMEs: NACHMAN, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Americas;Animals;Biology;Blood Chemical Analysis;Body mass index;Chromatin;Climate;Complex;Copy Number Polymorphism;Disease;DNA Insertion Elements;DNA Transposable Elements;Environment;environmental adaptation;Evolution;Gene Expression;Genes;Genetic;genetic architecture;Genetic Polymorphism;Genetic study;Genome;Genomics;Genotype;Geography;Goals;Health;Hi-C;House mice;Human;Inbred Strain;Inbreeding;Laboratories;Limb structure;Link;Mammals;Maps;Measures;Metabolic;Metabolic Diseases;Modeling;Mus;Pattern;Phenotype;Population;Quantitative Trait Loci;Research;Resources;Sampling;scaffold;Surveys;trait;transcriptome sequencing;Variant;Western Europe;Work

PROJECT_TITLE: The genomic basis of environmental adaptation in house mice

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Machine Learning in Atrial Fibrillation Narrative Atrial fibrillation (AF) is an enormous public health problem that affects 2-5 million Americans, causing stroke, rapid heart beats, heart failure and even death. In this project, the applicant will apply numerical analysis and machine learning to detailed data acquired from patients undergoing therapy, to better define individual biological types of AF, which may provide a foundation for personalized patient-tailored diagnosis and therapy.

PI_NAMEs: NARAYAN, SANJIV M (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Ablation;Action Potentials;Acute;Address;Affect;Algorithms;American;Anatomy;Area;Arrhythmia;Atrial Fibrillation;Biological;Biometry;Biostatistical Methods;Calibration;Cessation of life;Classification;Clinical;Clinical Data;Complex;complex data;Computer Models;computer science;Confusion;convolutional neural network;Data;Data Element;data integration;Data Set;demographics;Diagnosis;digital;Disease;Dizziness;Drug Controls;Electrophysiology (science);experience;Foundations;Funding;Genetic;Heart;Heart Atrium;Heart failure;heart rhythm;Hospitalization;Human;Image Analysis;improved;Individual;individual patient;individualized medicine;insight;Label;Lesion;Link;Machine Learning;machine learning classifier;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Medicine;Methods;mortality;Noise;novel;Outcome;Patient Care;Patients;Pattern;personalized medicine;personalized strategies;Persons;Phenotype;Physics;Physiological;Play;prospective;prospective test;Public Health;Recovery;Registries;response;Science;signal processing;Signal Transduction;Site;Stroke;success;Test Result;Testing;Tissues;tool;Training;translational impact;Uncertainty;United States National Institutes of Health;voice recognition;voltage;Work

PROJECT_TITLE: Machine Learning in Atrial Fibrillation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Immunotherapy;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In traumatic brain injury (TBI), persistent neuroinflammation contributes to disease progression and poor outcome, and microglia plays a critical role in the neuroinflammatory response following injury. We have discovered a mechanism to decrease the inflammatory nature of microglia, so they are more protective rather than disease-inducing by the nasal administration of anti-CD3 that stimulates immune cells to travel to the brain and decreases inflammation. This work seeks to test this treatment in animal models of TBI to determine its effect on the brain and immune system over time and potentially generate novel therapeutic options for the millions of Americans with TBI.

PI_NAMEs: IZZY, SAEF  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Ablation;Acute;Acute Brain Injuries;adaptive immune response;Adaptive Immune System;adaptive immunity;Aftercare;American;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Area;Attenuated;Autoimmune Diseases;Behavior;Behavioral;behavioral outcome;Biochemical;Bioinformatics;Biological;Brain;brain cell;Brain Injuries;C57BL/6 Mouse;career;CD3 Antigens;cell motility;Cells;Cervical lymph node group;Chronic;Chronic Phase;clinical application;Coculture Techniques;Cognitive;cognitive function;controlled cortical impact;Cortical Contusions;cost;cytokine;Data;disability;Disease;Disease Progression;effective therapy;effector T cell;experience;experimental study;Flow Cytometry;FOXP3 gene;Funding;glial activation;Goals;Health;Hippocampus;Hour;Human;Immune response;Immune system;Immunologic Stimulation;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Innate Immune System;insight;Interleukin-10;interleukin-10 receptor;Interleukin-4;Ipsilateral;Knowledge;Learning;Lesion;Mechanics;Mediating;Mentors;Microglia;migration;Modeling;Molecular;Monoclonal Antibodies;Motor;mouse model;Multiple Sclerosis;Mus;Nature;neural;neuroimmunology;neuroinflammation;Neurologic Deficit;neurological recovery;neuropathology;neurotoxic;neurotoxicity;Nose;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phenotype;Play;protective effect;Regulation;Regulatory T-Lymphocyte;Rehabilitation therapy;Research;Research Personnel;response;Role;Short-Term Memory;Signal Transduction;Surveys;T cell response;T-Lymphocyte;Tamoxifen;TBI treatment;Testing;Therapeutic Effect;Time;Training;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Traumatic Brain Injury;Traumatic Brain Injury recovery;Travel;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Targeting CNS Neuroinflammation in Traumatic Brain Injury by Nasal Anti-CD3

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Nutrition;Parkinson's Disease;Prevention

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Parkinson’s disease (PD) develops insidiously over many years and by the time patients are diagnosed, extensive neurodegeneration has already occurred and it is too late to prevent disability; earlier interventions would be more likely to succeed in arresting or delaying the disease progress. We propose therefore to conduct a large longitudinal investigation to identify individuals with prodromal PD, and to elucidate its natural history, heterogeneity, and rates of progression, including the possible impact of covid-19 and the contribution of novel biomarkers. The project will take advantage of well-established cohorts comprising over 50,000 individuals who have already provided extensive and validated data, and stands to provide in an efficient manner the in-depth knowledge on prodromal PD that is needed to initiate prevention trials.

PI_NAMEs: ASCHERIO, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: 2019-nCoV;Address;Adrenergic beta-Antagonists;Adult;Agonist;algorithm training;Antigens;Appearance;Biological;Biological Markers;Brain;Caffeine;Carnitine;case control;Clinical;cohort;Constipation;COVID-19;COVID-19 impact;Data;design;Diagnosis;dietary;Dietary Practices;Disability prevention;Disease;Disease Progression;disorder risk;Early identification;Early Intervention;Event;experience;Flavonoids;follow-up;Follow-Up Studies;Food;Funding;Future;Genetic Complementation Test;Goals;Health Professional;Heterogeneity;hyposmia;Individual;insight;Intervention;Investigation;Knowledge;Life;Life Style;Lipids;Machine Learning;Medical History;men;Metabolism;metabolome;modifiable risk;Monitor;Motor;Movement Disorders;National Institute of Neurological Disorders and Stroke;Natural History;Nerve Degeneration;novel;novel marker;Nurses' Health Study;Nutrient;Parkinson Disease;Parkinsonian Disorders;Participant;Patients;Pharmaceutical Preparations;Phase;Physical activity;Play;Population;Positioning Attribute;prediction algorithm;Prevention trial;Probability;prospective;Recommendation;recruit;REM Sleep Behavior Disorder;Research;Resources;Risk Factors;Role;Sampling;screening;Sebum;sex;Smoking;Societies;Source;Sphingolipids;Subgroup;Surveys;Testing;Time;Training;virtual;Volatilization;Woman;Women's cohort

PROJECT_TITLE: Biomarkers and risk factors for prodromal Parkinson's disease and its progression

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Multiple Myeloma is an incurable cancer of the blood that takes the lives of over 12,000 people every year. It remains a difficult disease to treat due to its genetic complexity from the earliest stages of the disease, indicating a need for a precision medicine approach in treating these patients. In this application Icahn School of Medicine at Mount Sinai will partner with Cancer Genetics, Inc. to develop a multi-omics clinical decision assay that will improve long-term outcomes for patients with advanced myeloma and generate valuable insights and tools that can be broadly leveraged for other disease indications.

PI_NAMEs: PAREKH, SAMIR  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Academia;Address;Affect;Algorithms;Alzheimer's Disease;Animal Model;Area;Big Data;Biological Assay;Biological Sciences;Bone Marrow;cancer genetics;Classification;clinic ready;Clinical;Clinical Data;clinical decision support;Clinical Trials;clinically actionable;Clonality;Collaborations;computational pipelines;Computer Models;computerized tools;Data;data integration;design;Development;Diagnosis;Disease;disorder subtype;DNA Sequence Alteration;drug repurposing;Drug resistance;efficacy testing;Employment;Event;Genes;Genetic;Genetic Diseases;Genetic Heterogeneity;genomic data;genomic profiles;Genomics;Health;Hematopoietic Neoplasms;Heterogeneity;improved;improved outcome;in vivo;individual patient;Industry;Inflammatory Bowel Diseases;insight;Intake;Learning;longitudinal design;Machine Learning;Malignant Neoplasms;Measurement;medical schools;Modeling;Monitor;mouse model;multidisciplinary;Multiple Myeloma;multiple omics;Mus;next generation;novel;novel therapeutic intervention;novel therapeutics;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peripheral arterial disease;personalized medicine;personalized therapeutic;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physicians;pilot trial;Plasma Cells;point of care;precision medicine;Precision therapeutics;Prediction of Response to Therapy;predictive tools;Primary Neoplasm;profiles in patients;prospective;Recommendation;Refractory;Relapse;relapse patients;Research;Research Priority;risk stratification;RNA;Sampling;Schizophrenia;Scientist;Selection for Treatments;Solid Neoplasm;standard of care;statistical and machine learning;Stream;Suggestion;support tools;Systems Biology;Systems Integration;targeted sequencing;Technology;Testing;Therapeutic;Time;tool;transcriptome sequencing;transcriptomics;Translating;treatment planning;treatment response;tumor;tumor xenograft

PROJECT_TITLE: Development of a multi-omic clinical decision platform to guide personalized therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_CITY: NEW HAVEN

ORG_NAME: CONNECTICUT AGRICULTURAL EXPERIMENT STA

ORG_STATE: CT

PHR: Brackney & Armstrong Narrative. Arthropod-borne (arbo-) viruses poses a continued and significant public health threat despite vast expenditures towards their control. Understanding the transmission dynamics and how vector behavior influences these dynamics will be critical to developing novel control strategies required to reduce human disease risk. Therefore, we will be examining the effect that the biologically-relevant multiple bloodfeeding behavior has on arbovirus infection within vector mosquitoes.

PI_NAMEs: ARMSTRONG, PHILIP M.;BRACKNEY, DOUGLAS E. (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Alpha Virus;Anatomy;Arbovirus Infections;Arboviruses;Arthropod Vectors;arthropod-borne;Basal lamina;Behavior;behavior influence;Behavioral;Biological;Biology;Biophysics;Blood;Chikungunya virus;Communities;Competence;Culex (Genus);Culicidae;Data;Dengue Virus;Disease Outbreaks;disorder risk;epidemic potential;Expenditure;feeding;Feeding behaviors;Flaviviridae;Flavivirus;Goals;Health;Human;human disease;human pathogen;Incubated;Infection;Intervention;La Crosse virus;Laboratories;Mediating;Midgut;mosquito-borne;novel;Oogenesis;Ovarian;Ovarian Tissue;Ovary;pathogen;Perforation;Phenotype;Population;Process;Protocols documentation;Public Health;Readiness;Research;Risk;Risk Estimate;Role;success;Testing;Time;Tissue Harvesting;Togaviridae;transmission process;vector;vector competence;vector mosquito;vector transmission;Vertical Transmission;Viral;Virus;West Nile virus;Yellow fever virus;Zika Virus;ZIKV infection

PROJECT_TITLE: Implications of sequential bloodmeals on arbovirus transmission by mosquitoes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: UTMB’s CTSA Hub will work with local, regional, and national partners to support translational research and accelerate discoveries toward better health. We will provide workforce training and build multidisciplinary teams to conduct efficient, high-quality clinical research across the lifespan. We will integrate our research and healthcare activities and will generate, apply, and share data and best practices across institutions.

PI_NAMEs: URBAN, RANDALL J (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African American;Age;analytical tool;career;Characteristics;Clinic;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Clinical Skills;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;community engagement;comparative effectiveness;Country;Course Content;Data;data platform;data resource;data sharing;design;Discipline of Nursing;Diverse Workforce;Education;Educational Curriculum;effective intervention;Effectiveness;Entrepreneurship;Ethnic Origin;experience;Gender;Geriatrics;Goals;Hand;Health;health goals;Health Occupations;Health Sciences;Health system;Healthcare Activity;Heterogeneity;Hispanic;Home;Hospitals;improved;Individual;Informatics;informatics infrastructure;informatics training;innovation;Institution;Institutional Review Boards;inter-institutional;interoperability;knowledge base;Leadership;Learning;life span;Medical;medical schools;meetings;Methodology;Methods;Minority;Mission;Modeling;Multi-Institutional Clinical Trial;multi-site trial;multidisciplinary;National Center for Advancing Translational Sciences;Native Americans;novel;operation;Outcomes Research;Participant;Patient Care;patient population;Patient-Focused Outcomes;Pediatrics;Phase;Population;Pregnancy;programs;Race;Research;Research Personnel;Research Support;Resource Sharing;Resources;Schools;Science;Services;skills;Source;Special Population;Structure;Technology;Testing;Texas;Training;Translation Process;translational pipeline;Translational Research;Universities;Work

PROJECT_TITLE: UTMB Clinical and Translational Science Award


PROJECT_TERMS: Address;Advocacy;Cities;Clinical and Translational Science Awards;Clinical Research;Communication;Communities;community collaboration;community engagement;community partners;Development;Discipline;Education;Ensure;Foundational Skills;Health;Health Priorities;Industry;innovation;interest;Leadership;Life Cycle Stages;life span;Medicine;meetings;member;Methods;multidisciplinary;Outcome;outreach;patient engagement;Patients;Phase;Policy Maker;Process;programs;Research;Research Design;Research Personnel;Science;Sister;Testing;Texas;Training;Training Programs;Translating;translational engagement;translational pipeline;Translational Research;United States National Institutes of Health


ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: PROJECT NARRATIVE Phase III funding for the Center for Cancer Biology Research will provide continued support for the Center's Scientific Cores such that they can attain self-sustainability. This funding will also provide resources for a Pilot Grant program to continue supporting innovative cancer research in the Midwest. Together, our Center will continue to expand and generate innovative and impactful research that will ultimately benefit cancer patients.

PI_NAMEs: MISKIMINS, W KEITH (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: anti-cancer research;Applications Grants;Award;Back;Basic Cancer Research;Cancer Biology;Cancer Center;Cancer Patient;Cancer Research Infrastructure;Centers of Research Excellence;Communities;Core Facility;Data;editorial;expectation;Extramural Activities;Faculty;Fee-for-Service Plans;Funding;Funding Agency;Funding Mechanisms;Goals;Grant;improved;Infrastructure;innovation;Institution;Journals;Manuscripts;member;Midwestern United States;Mission;Paper;Peer Review;Phase;Physicians;Principal Investigator;programs;Publications;Publishing;recruit;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Resources;Schedule;Science;Scientist;Seasons;Secure;Services;Sioux Falls;Source;Study Section;success;Teacher Professional Development;Testing;Time;translational cancer research;Translational Research;United States National Institutes of Health;voucher

PROJECT_TITLE: Center for Cancer Biology Research


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Address;Area;Assessment tool;Award;Bioinformatics;Biomedical Research;career;Categories;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;community engagement;Competency-Based Education;design;Devices;Entrepreneurship;Environment;Ethical Issues;Evaluation;Extramural Activities;feasibility trial;Fostering;Foundations;Funding;Goals;Good Clinical Practice;Grant;Growth;Human Subject Research;implementation science;improved;Institution;Intellectual Property;Investments;Knowledge;Leadership;Manuscripts;Medical Informatics;Mentors;multidisciplinary;National Center for Advancing Translational Sciences;novel;Nurses;Patient Care;Physicians;Pilot Projects;profession allied to medicine;programs;Research;Research Design;Research Personnel;Resources;rural area;Science;Scientific Advances and Accomplishments;Scientist;Site;skills;Therapeutic;TNFSF15 gene;training opportunity;Translation Process;Translational Research;translational scientist;Translations;Universities;voucher;Workforce Development


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Address;Advisory Committees;Agreement;Annual Reports;anti-cancer research;Applications Grants;Area;base;Budgets;Cancer Biology;Cancer Center;cohesion;Collaborations;Committee Members;Consultations;Country;Data;Decision Making;Development;Disputes;Eligibility Determination;Ensure;Faculty;falls;Fee-for-Service Plans;Feedback;Fees;Flow Cytometry;Fostering;Funding;Goals;Grant;Histology;Image;Immune response;individual responsibility;innovation;Institution;Joints;Lead;Leadership;Malignant Neoplasms;Manuscripts;meetings;member;Mentors;Mission;nerve supply;North Dakota;operation;Phase;Pilot Projects;Principal Investigator;Productivity;Program Reviews;programs;Progress Reports;Publications;Report (document);Reporting;Research;Research Activity;research faculty;Research Personnel;Resolution;Role;Scientific Evaluation;Services;Site;Specialist;Structure;success;System;tumor;tumor microenvironment;United States National Institutes of Health;Universities;virtual;voucher;waiver;Work;Writing

PROJECT_TITLE: Administrative Core


ORG_CITY: FORT COLLINS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative A complete understanding of the mechanisms employed to regulate gene expression is necessary to combat the aberrant regulation that underlies many human developmental conditions and ailments, including cancer. The long-term goals of our research efforts are to determine the regulation imposed on the essential multi-subunit RNA polymerase during each stage of the transcription cycle, including regulation imposed by chromatin structure and to specifically characterize the available mechanisms to regulate transcription through histone- bound DNAs. The results obtained will determine the mechanisms that support transcription regulation, transcription elongation on chromatin templates, describe the activities of conserved and domain-specific transcription factors, and detail the role of extended chromatin structures and genome architecture on gene regulation.

PI_NAMEs: SANTANGELO, THOMAS JAMES (contact)

PROJECT_TERMS: Acceleration;Address;Architecture;Attention;Chromatin;Chromatin Structure;combat;Complex;Development;Disease;DNA Binding;DNA-Directed RNA Polymerase;Eukaryotic Cell;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;genome-wide;Goals;Histones;Human;Knowledge;Malignant Neoplasms;Molecular;Regulation;Research;Role;System;Transcription Elongation;transcription factor;transcription termination;Transcriptional Regulation;Variant

PROJECT_TITLE: Regulation of Archaeal Transcription


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services

PROJECT_TERMS: Area;Basic Science;Bioinformatics;Biometry;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Comparative Effectiveness Research;Complex;Consultations;Country;Data;data management;data mining;data quality;Databases;Documentation;Education;eHealth;electronic consent;Epidemiology;Ethics;experience;Experimental Designs;Faculty;faculty support;Health;improved;Informatics;innovation;Joints;Knowledge;Mentors;Methods;Mission;Modeling;multidisciplinary;novel;Outcome;Outcomes Research;Pathway Analysis;Patient Recruitments;Patient-Focused Outcomes;Performance;Pharmacotherapy;Play;Process;programs;Publications;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;service organization;Services;Statistical Data Interpretation;Students;Techniques;tool;Toxic effect;Training;Training and Education;Translational Research;translational study;Translations;trial design


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Prevention;Rare Diseases

PROJECT_TERMS: Addictive Behavior;age group;Area;arm;Child;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Communities;Data Coordinating Center;education research;Epidemic;Goals;Hispanic Populations;Human;Individual;Informatics;innovation;Link;mastocytosis;Maternal-fetal medicine;Methods;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;neonate;novel;older adult;opioid use;outreach;Participant;Porphyrias;Pregnant Women;Preventive care;programs;Quality Control;Rare Diseases;Research;Research Personnel;Resources;Safety;Special Population;tool;Training;Translational Research;underserved community;vaccine development;Workforce Development


NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Genetic Testing;Genetics;Health Services;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Recent evidence suggests that up to 10% of patients with Pancreatic Ductal AdenoCarcinoma (PDAC) harbor a germline genetic mutation in a cancer risk gene, and genetic testing is now recommended for all patients. However, the best ways to perform this testing – and to use the resulting information to help patients and their family members – remain unclear. We hypothesize that by using a simulation modeling approach, we can identify effective and high-value genetic testing strategies for patients with PDAC, including potential benefits both to patients and their family members.

PI_NAMEs: PETERS, MARY LINTON B (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;Award;BRCA2 Mutation;Calibration;Cancer Model;cancer risk;career;career development;Cessation of life;chemotherapy;Clinical;Clinical Trials;Communication;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Data;Decision Analysis;design;Detection;Development;Development Plans;Diagnosis;disease model;Distress;DNA Sequence Alteration;Education;Effectiveness;effectiveness analysis;Evaluation;experience;family genetics;Family member;First Degree Relative;Funding;Genes;genetic approach;Genetic Models for Cancer;genetic panel test;genetic testing;Germ Lines;Germ-Line Mutation;Goals;Image;Individual;innovation;insight;Knowledge;knowledge base;Lesion;Life Expectancy;Literature;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;mathematical model;Mentorship;Methodology;Modeling;models and simulation;Mutation;mutation carrier;National Comprehensive Cancer Network;Natural History;Notification;Outcome;Outcomes Research;oxaliplatin;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patient-Focused Outcomes;Patients;Pilot Projects;Positioning Attribute;Probability;programs;Publishing;Recommendation;Research;Research Personnel;Resources;Risk;risk minimization;risk variant;Role;Scientist;screening;Secure;SEER Program;Selection for Treatments;Solid;Structure;Surveys;teacher;Test Result;Testing;Work

PROJECT_TITLE: Cost Effectiveness of Germline Genetic Testing in Pancreatic Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Area;Clinical and Translational Science Awards;clinical center;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Computer software;Development;Effectiveness;Environment;feasibility trial;Health;Improve Access;improved;Informatics;informatics infrastructure;innovation;interoperability;Link;Measures;Methodology;Multi-Institutional Clinical Trial;novel;Patient Recruitments;programs;recruit;Regulation;Reporting;Research Infrastructure;Research Personnel;Resources;Science;Site;tool;Training;Training Programs;web site;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Pediatric

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Infants of depressed mothers and children diagnosed with autism spectrum disorders show reduced sensitivity to social reward, which may disrupt their ability to prioritize attention to and learning from their caregivers. However, past research examining infants’ attention orienting has emphasized mechanisms based on perceptual salience and endogenous control without addressing the role of social-motivational factors (e.g., caregiving quality). The proposed research investigates the extent to which social-motivational factors and endogenous attention control predict attention orienting to caregivers in infancy, with a long-term goal of understanding mechanisms that link social reward processing to early attention in both typical and atypical development.

PI_NAMEs: MARKANT, JULIE CHRISTINA (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TITLE: Longitudinal investigation of endogenous and social-motivational predictors of infants' attention to caregivers

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: CHANDRASEKAR, INDRA  (contact)

PROJECT_TITLE: Imaging and Histology Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PROJECT_TERMS: 14 year old;Address;Adolescent;Age;care outcomes;Caring;Case Based Learning;Categories;Cessation of life;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Research;Communities;Community Healthcare;Community of Practice;Community Physician;County;Databases;Development;Ecosystem;Education;Electronic Health Record;Epidemiologic Monitoring;evidence base;experience;Faculty;Family Practice;Future;Goals;Health Personnel;Healthcare;high risk;improved;Information Technology;integrated care;Knowledge;Maternal and Child Health;Mental disorders;Mental Health Services;Morbidity - disease rate;Opioid;opioid mortality;opioid overdose;opioid use;opioid use disorder;Patient Care;Pattern;Perinatal mortality demographics;Physicians;Poison;Population;Pregnancy;Prevention program;Prevention strategy;programs;Quality of Care;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Risk Factors;Rural;Rural Community;Schools;Students;substance use;Substance Use Disorder;teacher;Texas;Translating;Translations;underserved community;United States;Urban Community;violence prevention;Woman;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Diabetes;Health Services;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The optimal diabetes care for nursing home residents with both diabetes and cognitive impairment is unclear. The proposed studies will examine current diabetes care practices in NH residents across the spectrum of cognitive impairment and determine which practices are associated with better (and worse) outcomes. This study will build the evidence base for diabetes care for nursing home residents with diabetes and cognitive impairment, which will ultimately lead to improved guidelines, improved care and improved outcomes for these vulnerable older adults.

PI_NAMEs: LEE, SEI  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Admission activity;adverse outcome;Aging;Alzheimer's disease related dementia;American;Benefits and Risks;care outcomes;career;career development;Caring;Clinical;clinical care;clinical practice;Clinical Research;Cognitive;colorectal cancer screening;Communication;Data;Data Set;Dementia;Dependence;Diabetes Mellitus;disadvantaged background;Elderly;Electronic Health Record;evidence base;Faculty;Fingers;functional outcomes;Funding;Future;Glucose;glucose monitor;Glycosylated hemoglobin A;Goals;Guidelines;high risk;Home Nursing Care;Hypoglycemia;Impaired cognition;improved;improved outcome;Insulin;interest;Intervention;Investigator-Initiated Research;Laboratories;Leadership;Life Expectancy;Link;Measurement;Measures;Mentors;Mentorship;Metformin;Microvascular Dysfunction;Modeling;Monitor;mortality;nursing home length of stay;Nursing Homes;older adult;older patient;Outcome;overtreatment;Patients;personalized care;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Population;programs;Public Health;Publishing;Recommendation;Research;Research Personnel;Research Support;Risk;Severities;skills;Symptoms;System;Time;United States Department of Veterans Affairs;Validation;Veterans;Work

PROJECT_TITLE: Improving Care for Nursing Home residents with Diabetes and Cognitive Impairment

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


PROJECT_TERMS: Acceleration;Address;Age;analytical tool;Characteristics;Clinical and Translational Science Awards;Clinical Research;Communities;community engagement;data platform;design;Diverse Workforce;Education;Educational Curriculum;effective intervention;Effectiveness;Ethnic Origin;experience;Gender;Hand;Health;health goals;Home;improved;Individual;informatics infrastructure;informatics training;innovation;Institution;inter-institutional;interoperability;knowledge base;Leadership;Learning;life span;Medical;meetings;Methods;Modeling;Multi-Institutional Clinical Trial;multi-site trial;multidisciplinary;National Center for Advancing Translational Sciences;novel;operation;Participant;Phase;programs;Race;Research;Research Personnel;Research Support;Resource Sharing;Resources;Science;skills;Special Population;Technology;Testing;Texas;Training;Translation Process;translational pipeline;Translational Research;Universities;Work


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative. After treatment for unilateral vocal fold paralysis, some patients report symptoms that are consisted with reduced vocal efficiency. We propose looking at how and why different surgical treatments for UVFP affect vocal efficiency.

PI_NAMEs: OREN, LIRAN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: The Relationship Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Infants asphyxiated at birth represent a serious problem worldwide. There is a need for development of neurophysiological and neuroimaging biomarkers providing accurate measures of neurovascular and metabolic functions– critical components of brain health in babies. This proposal is relevant to public health as the wavelet biomarkers can improve identification of brain injury at birth, guide patient selection for therapeutic interventions in mild HIE, keeping with the NINDS mission to reduce the burden of neurological disease.

PI_NAMEs: CHALAK, LINA F (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Affect;Alternative Therapies;Asphyxia;Biochemical;Biological;Biological Markers;Biomedical Engineering;Birth;Blood Vessels;Brain;brain health;Brain Injuries;Cessation of life;Circulation;Classification;Clinical;clinical examination;Cognitive;cohort;community engagement;Coupling;Data;Detection;Development;disability;disability risk;Electroencephalography;Electrophysiology (science);Encephalopathies;Enrollment;Ensure;Environment;Evolution;Failure;Family;follow-up;functional outcomes;Funding;Future;Goals;hemodynamics;Homeostasis;Hospitals;Hour;Image;Impairment;improved;improved outcome;Individual;Infant;Infrastructure;Injury;insight;Intervention;Knowledge;Life;Magnetic Resonance Imaging;Maps;Measures;Metabolic;metabolic rate;Metabolism;Mission;model design;Monitor;multidisciplinary;multimodality;National Institute of Neurological Disorders and Stroke;natural hypothermia;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;Neonatal Mortality;neonate;Nervous System Disorder;neurobiological mechanism;Neurodevelopmental Impairment;neuroimaging;neuroimaging marker;Neurologic;Neurons;neurophysiology;neuroprotection;neurovascular;neurovascular coupling;Newborn Infant;novel;Outcome;outcome prediction;Oxygen;Oxygen Consumption;parent grant;Patient Selection;Perfusion;Phase;Physiological;Population;postnatal;predictive marker;predictive modeling;Predictive Value;primary outcome;Process;Public Health;Publications;randomized trial;Relaxation;Research;Research Personnel;secondary outcome;Severities;Signal Transduction;Socioeconomic Factors;Spectrum Analysis;Stratification;Structure;success;Supportive care;Surrogate Endpoint;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Treatment Efficacy;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal Encephalopathy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


PI_NAMEs: DE LA PUENTE, PILAR  (contact)

PROJECT_TERMS: Applications Grants;base;Cancer Biology;Cancer Center;Cell Separation;Consult;Core Facility;Data;Data Analyses;Data Collection;design;Development;Disease;Education;Ensure;Equipment;equipment acquisition;experience;Experimental Designs;Faculty;Fee-for-Service Plans;Flow Cytometry;Funding;Future;Goals;Grant;Growth;Health;Human;Human Resources;Image;Infrastructure;Institution;instrument;instrumentation;Maintenance;Manuscripts;Mission;novel;operation;Persons;Phase;Preparation;Principal Investigator;Protocols documentation;Publications;Research;research faculty;Research Personnel;Resource Sharing;Sampling;Schedule;Scientist;Secure;Services;Site;Sorting;Structure;Techniques;Training;Training and Education;Translating;United States National Institutes of Health;Update;Wages;webinar;Work

PROJECT_TITLE: Flow Cytometry Core


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE In the United States, young Black males have a substantially greater need for sexual reproductive health (SRH) services and are at a higher risk of contracting sexually transmitted infections (STIs) than other young adult populations. This study aims to examine if new media can positively inform, educate, and reach young Black men, resulting in improved access to sexual reproductive healthcare and safe sex behaviors. The information gained from this study will promote the health and wellness of a community of young men both online and in person and assist in developing culturally relevant sexual health interventions for generations and beyond.

PI_NAMEs: BURNS, JADE ANDREA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;African American;Age;Attitude;Behavior;Behavior Therapy;Belief;black men;Black race;career;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Chlamydia;cohort;Communities;community partners;Contracts;Data;Data Analyses;Data Analytics;data mining;Data Set;design;Development;Diagnosis;early sex initiation;Economic Factors;effective intervention;Ensure;Environmental Risk Factor;ethnic disparity;Evidence based program;examination questions;experience;Family;Fright;Generations;Genetic Transcription;Goals;Gonorrhea;Growth;Health;health care availability;health care quality;health determinants;health disparity;Health Promotion;Health Services;Health Services Accessibility;Healthcare;Heterosexuals;high risk;HIV;HIV/STD;Improve Access;improved;Individual;infection burden;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Latino;Learning;longitudinal analysis;Media Campaign;Mentors;Methodology;Methods;Modeling;National Institute on Minority Health and Health Disparities;Natural Language Processing;novel;Outcome;peer;Persons;Population;Process;programs;Publishing;racial disparity;Randomized, Controlled Trials;Recommendation;Reproductive Health Services;Research;Research Methodology;Research Personnel;Risk;Risk Reduction;Safe Sex;screening;secondary analysis;Sex Behavior;sexual and reproductive health;Sexual Health;sexual health intervention;Sexual Partners;sexual risk behavior;Sexually Transmitted Diseases;Shame;Shapes;Site;skills;social factors;social media;social networking website;social norm;social stigma;Societies;STI prevention;Structure;Syphilis;Testing;Training;transmission process;United States;urban setting;Vulnerable Populations;Work;young adult;young man;Youth

PROJECT_TITLE: The Use of New Media to improve Access to Sexual Reproductive Health Services among Young Black Males in a Community-Based Setting


PROJECT_TERMS: Address;anti-cancer research;Applications Grants;base;Cancer Biology;Cancer Center;Collaborations;Critiques;Data;Data Collection;Diagnostic;Eligibility Determination;Ensure;Extramural Activities;Fee-for-Service Plans;Fees;Foundations;Funding;Funding Agency;Goals;Grant;innovation;Institution;Investments;Journals;Malignant neoplasm of pancreas;Midwestern United States;Mission;North Dakota;Peer Review;Phase;Pilot Projects;Process;programs;Publications;Research;Research Personnel;Source;stem;success;System;Therapeutic;Time;United States National Institutes of Health;Universities;voucher;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Rehabilitation;Sickle Cell Disease

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Cognitive impairment is a pervasive debilitating feature of sickle cell disease (SCD), with over 50% of children demonstrating early neurodevelopmental delays, ultimately influencing ability for adolescents with SCD to engage in effective decision-making needed for successful transition into adulthood. This study will examine the efficacy of a cognitive remediation program (CRP) to improve decision-making skills in youth with SCD (10-18y) in order to enhance self-care and self-advocacy to improve and maintain transition readiness skills. This research proposal will fill several major gaps in the understanding of remediation of cognitive deficits in SCD and will lay the groundwork for evidence-based interventions aimed to improve transition of care, enhance self-care, and ultimately improve life expectancy.

PI_NAMEs: MURDAUGH, DONNA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: acute chest syndrome;Admission activity;Adolescent;Adopted;Adult;Advocacy;African American;African American population;Age;age related decline;aged;Antibiotic Prophylaxis;Area;arm;Behavioral;Brain;Brain Injuries;Brain region;career;career development;Caring;Cause of Death;Cessation of life;Characteristics;Child;Childhood;Chronic;Clinical;Clinical Trials Design;Cognitive;cognitive change;Cognitive deficits;cognitive function;Cognitive remediation;Conduct Clinical Trials;Coupled;Decision Making;Deep South;Deposition;deprivation;Development;Development Plans;Disease;Disparity;early childhood;Education;efficacy evaluation;Enrollment;Erythrocytes;Evidence based intervention;executive function;experience;feasibility testing;follow-up;Foundations;Functional Magnetic Resonance Imaging;Future;gene therapy;Genetic;Goals;Health;Healthcare;Hematological Disease;high risk;hydroxyurea;Impaired cognition;improved;indexing;Infection;Intervention;Iron;K-Series Research Career Programs;Life;Life Expectancy;life span;Longitudinal Studies;male;Malignant Neoplasms;Measures;Medical;Mentors;Methodology;minority engagement;Minority Groups;Morbidity - disease rate;multimodal neuroimaging;Nature;Neonatal Screening;neural;Neurobiology;Neurocognitive;neuroimaging;Neurologic;neuromechanism;Neurophysiology - biologic function;Neuropsychological Tests;Outcome;parenting intervention;Parents;patient oriented;Patient Self-Report;Patients;Pattern;premature;Prevalence;prevent;programs;Psychological reinforcement;Quality of life;Randomized, Controlled Trials;Readiness;remediation;Research;Research Methodology;Research Personnel;Research Proposals;response;Rest;Risk;satisfaction;Scientist;Self Assessment;Self Care;Sickle Cell Anemia;skills;social health determinants;Stem cell transplant;Stroke;success;Survival Rate;survivorship;telehealth;Testing;Time;Training;Transfusion;transition to adulthood;vaso-occlusive crisis;Waiting Lists;Work;Youth

PROJECT_TITLE: Longitudinal study of cognitive remediation to prepare for transition of care in youth with sickle cell disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Public Health Relevance Project Narrative Increased access and high prevalence of cannabis use are accompanied by the widespread public perception of cannabis as favorable and therapeutic, despite limited supporting evidence from medical science. However, little is known about where such health claim messages originate and how they may influence the user’s beliefs and behaviors. The project will provide information on the sources, content, and impact of disseminated messages that can guide cannabis regulatory practices and ultimately reduce potential harms from cannabis misuse.

PI_NAMEs: JACKSON, KRISTINA MELIA;METRIK, JANE  (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Adopted;Area;arm;Automobile Driving;Behavior;Belief;Benefits and Risks;cannabinoid treatment;Cannabis;Cannabis policy;cannabis use behavior;Cellular Phone;Characteristics;chronic pain;Code;Cognition;Consumption;Data;Data Collection;design;Ecological momentary assessment;Environment;Event;evidence base;Evolution;Exposure to;Familiarity;General Population;Grain;Health;Health Personnel;High Prevalence;high risk;Individual;Internet;Interview;Investigation;marijuana legalization;marijuana use;marijuana user;Measures;Mediating;Mediation;Medical;Medical Marijuana;Mental Health;Methods;Multiple Sclerosis;painful neuropathy;Participant;Patient Self-Report;Patients;Pattern;Perception;Persons;Pharmaceutical Preparations;Phase;physical conditioning;Policy Maker;Prevalence;Process;prospective;public health relevance;Recreation;reduce symptoms;Reporting;Research;Risk;Role;Sampling;Science;Series;Shapes;social media;sociodemographics;Source;Statutes and Laws;Structure;Testing;Therapeutic;Therapeutic Effect;Thinking;time interval;tool;transmission process;US State

PROJECT_TITLE: A Multi-Method Investigation of Cannabis Messaging: Characterizing Source, Content, and Associations with Cannabis Consumption


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Well-designed and well-conducted clinical trials are the primary means for evaluating new cancer therapies, advancing cures, reducing morbidity and mortality, and improving patient outcomes. The SWOG SDMC aims to be a leader in innovative trial design and analysis of science-driven publically funded Phase II and Phase III trials and translational medicine studies. Furthermore, our timely and high-quality trial implementation, management, and reporting ensure that the results of clinical trials have the greatest potential impact on cancer patients.

PI_NAMEs: LEBLANC, MICHAEL L. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Advisory Committees;anti-cancer research;Biological Markers;cancer clinical trial;Cancer Patient;cancer therapy;Cessation of life;Clinical Medicine;Clinical Sciences;clinical translation;clinical trial analysis;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Computer software;Conduct Clinical Trials;Data;Data Coordinating Center;data management;Data Science;data sharing;Databases;design;Ensure;Evaluation;Fostering;Funding;Goals;Immunotherapy;improved;indexing;innovation;International;Leadership;Link;Medicare;meetings;Mentors;Methodology;Mission;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;National Cancer Institute;novel strategies;Oncology;outreach;Patient-Focused Outcomes;Patients;Phase;phase III trial;precision medicine;programs;Publications;Reporting;repository;Reproducibility;Research;Research Institute;Research Methodology;Research Personnel;Science;Software Tools;Southwest Oncology Group;Standardization;Statistical Data Interpretation;Statistical Methods;statistics;System;tool;translational medicine;Translational Research;trial design;working group

PROJECT_TITLE: SWOG Statistics and Data Management Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;biobank;biological specimen archives;Biometry;Child;Clinical Data;clinical development;Clinical Medicine;Clinical Sciences;clinical trial analysis;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Data;Data Analyses;Data Coordinating Center;data management;data science management;data sharing;Decision Making;design;Development;Ensure;Faculty;Fred Hutchinson Cancer Research Center;Genomics;Homes for the Aged;Hospitals;Immunotherapy;interest;Leadership;meetings;member;Methods;Monitor;multidimensional data;National Clinical Trials Network;NCI Center for Cancer Research;novel;organizational structure;precision medicine;programs;Research;Research Methodology;Research Personnel;Safety;Southwest Oncology Group;Statistical Methods;statistics;translational medicine;user-friendly;working group

PROJECT_TITLE: Administrative Core for SWOG SDMC


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Digestive Diseases;Lung;Nutrition;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Patients with acute respiratory distress syndrome often require artificial nutrition as part of their care, but questions remain about the optimal timing, level, route, and composition for the individual patient. Recent advances in precision medicine may help personalize delivery of nutrition if greater understanding of the clinical and biologic variables determining response to artificial nutrition is achieved. This proposal will perform biologic assays on existing biospecimens stored in the NHLBI Biologic Specimen Repository from one of the largest trials of nutrition in acute respiratory distress syndrome to help identify the variables influencing responses to one specific aspect of nutrition (level of nutrition) with the eventual goal of individualizing care.

PI_NAMEs: SHAH, FARAAZ ALI (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;adverse outcome;Advocate;Affect;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;Caring;Categories;Clinical;Complex;Computer Models;Critical Care;Critical Illness;Data;Death Rate;demographics;Dietary Intervention;Disease;Endocrine;Enrollment;Enteral;Enteral Feeding;Enteral Nutrition;Feeds;frontier;Funding;Future;Gastric Inhibitory Polypeptide;gastrointestinal;glucagon-like peptide 1;glucose metabolism;Goals;Guidelines;gut inflammation;Heterogeneity;Hormones;Hyperglycemia;Immune response;improved;incretin hormone;Individual;individual patient;Inflammation;Inflammatory;Insulin;insulin secretion;Intake;intestinal fatty acid binding protein;Intestinal permeability;Intestines;Investigation;Ischemia;Knowledge;Laboratories;Life;Liquid substance;lung injury;Methodology;Modeling;mortality;Motility;Multicenter Trials;muscle form;National Heart, Lung, and Blood Institute;Nausea and Vomiting;next generation;novel;Nutrient;nutrition;Nutrition Therapy;Nutritional Study;Observational Study;Outcome;Participant;Pathway interactions;Patients;Pattern;Permeability;personalized care;personalized nutrition;Persons;Phenotype;Physical Function;Physiological;Population;precision medicine;precision nutrition;Prediction of Response to Therapy;predictive marker;prevent;Process;Prognosis;Randomized;Recommendation;Recovery;response;Risk;Route;secondary analysis;Secondary to;Severity of illness;standard of care;Stomach;systemic inflammatory response;Testing;Thinness;treatment effect;treatment response;ventilation

PROJECT_TITLE: Precision Medicine for Nutrition in EDEN


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Despite achieving 44% PrEP coverage in our previous cohort of young Black MSM, HIV incidence in the group was still 6.2%/year. To further increase the impact of PrEP, we propose an early intervention to delay or avert PrEP discontinuations, offering of on-demand PrEP, and offering of STI PEP to a new cohort of 300 YBMSM in Atlanta. These interventions will work together to promote PrEP persistence and decrease new STI and HIV infections in these most vulnerable men.

PI_NAMEs: KELLEY, COLLEEN F;SULLIVAN, PATRICK SEAN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: aged;AIDS prevention;arm;black men who have sex with men;Characteristics;Clinical;cohort;condoms;Consultations;Counseling;Data;Diagnosis;diaries;Dose;Doxycycline;Drug usage;Early Intervention;Elements;Eligibility Determination;Enrollment;Epidemic;Evaluation;experience;falls;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;Hour;Incidence;Infection;innovation;insight;interest;Intervention;Lead;Measures;men;men who have sex with men;mobile application;motivational enhancement therapy;National Institute of Drug Abuse;novel;Oral;Outcome;Outcome Assessment;Pattern;peer;pill;Population;premature;prevent;Prevention approach;Prevention strategy;preventive intervention;primary outcome;Process Measure;Prophylactic treatment;prospective;randomized trial;Reporting;response;Risk;Role;screening;Services;sex;Sexually Transmitted Diseases;side effect;Study models;success;Surveys;System;trial design;United States;uptake;Visit;Work

PROJECT_TITLE: Parrying the Pitfalls of PrEP: Preventing Premature PrEP Discontinuation and STIs among Young Black MSM

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Adherence;Biological Markers;Cancer Science;cancer therapy;clinical translation;Clinical Trials;Clinical Trials Design;Collaborations;Computer software;Data Coordinating Center;Databases;design;Development;Ensure;Evaluation;Faculty;Goals;Immunotherapeutic agent;Information Dissemination;innovation;Lead;Manuscripts;Monitor;novel therapeutics;Phase;phase II trial;phase III trial;Process;Property;Reproducibility of Results;Research Methodology;research study;secondary analysis;software development;Software Tools;sound;Southwest Oncology Group;Standardization;Statistical Data Interpretation;Statistical Methods;statistics;System;targeted agent;Testing;translational medicine;trial design

PROJECT_TITLE: Statistics Core for SWOG SDMC


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Obesity is a preventable and treatable condition associated with the leading causes of death worldwide and disproportionately affects sexual minority women, yet little is known about the mechanisms that confer heightened risk for these populations. I propose a mixed methods study to examine development and maintenance of weight-related behaviors among sexual minority women using qualitative life history interviews and experience sampling methods, with study data used to inform a preliminary model by which minority stressors may increase risk for obesity that can be tested in a subsequent longitudinal R01 study. This K01 will result in an independent research program that addresses critical gaps in the understanding of obesity disparities among sexual minority women.

PI_NAMEs: FOWLER, LAUREN ALINA (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Adult;Affect;Age;American;Area;asexual;Behavior;Behavioral;behavioral health;Bisexual;cancer type;career development;Cause of Death;Chronic Disease;Cognition;Communities;community advisory board;Data;Data Analyses;Data Collection;Development;Diabetes Mellitus;Diet;Dietary intake;Discrimination;disease disparity;Disparity;Disparity population;Ecological momentary assessment;energy balance;Energy Intake;Ensure;Environment;ethnic minority;Ethnic Population;experience;Exposure to;Foundations;Funding;Gays;Generations;Health behavior;health determinants;Health Disparities Research;health disparity populations;Heart Diseases;Heterosexuals;Individual;Institute of Medicine (U.S.);intersectionality;Intervention;Interview;Knowledge;large scale data;lens;Lesbian;Lesbian Gay Bisexual Transgender;life history;Literature;longitudinal design;marginalization;marginalized population;men;Mentorship;Methods;minority health;minority health disparity;minority stress;minority stressor;Modeling;National Institute on Minority Health and Health Disparities;Obesity;obesity risk;Outcome;Overweight;pansexual;Pathway interactions;Patient Self-Report;Phase;Physical activity;Population;Populations at Risk;Predictive Factor;Prevalence;Prevention;programs;Qualitative Research;queer;racial minority;racial population;Research;Research Personnel;resilience factor;Risk;Risk Factors;Sampling;sedentary activity;Sex Orientation;sexual minority;sexual minority health;sexual minority health disparity;sexual minority women;skills;social;social stigma;statistics;Strategic Planning;Stress;Stroke;Subgroup;Testing;theories;Time;Training;United States;United States National Institutes of Health;Variant;Weight;Weight Gain;weight maintenance;Woman;Work

PROJECT_TITLE: A mixed methods approach to understanding obesity risk among sexual minority women


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Approximately 40 million people worldwide are living with HIV/AIDS; however, a protective vaccine or functional cure remain elusive despite four decades of intense research. The proposed Duke Center for HIV Structural Biology will provide new insights into the dynamics of HIV-1 entry and fusion with the host membrane, the Env-initiated immune activation of B-cell receptors, and the role of anti-Env antibodies in blocking viral rebound. The ultimate goal of these studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease mechanisms in HIV-1 infection and rebound.

PI_NAMEs: ACHARYA, PRIYAMVADA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Antibodies;antiretroviral therapy;atomic interactions;Autologous;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-Lymphocytes;Behavior;Binding;Biology;Blocking Antibodies;career;Cell membrane;Cells;Chronic Disease;Clinical;Clonal Expansion;Complex;Development;Disease;Disease remission;Economic Burden;Elements;env Glycoproteins;Epitopes;Evolution;Fab Immunoglobulins;global health;Glycoproteins;Goals;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;HIV/AIDS;Immune;immune activation;Immune Evasion;Immune response;Immune system;Immunobiology;Immunoglobulin Fragments;Immunoglobulin Somatic Hypermutation;Individual;Infection;innovation;insight;Kinetics;Knowledge;latent HIV reservoir;Mediating;Membrane;Methods;Molecular Conformation;molecular dynamics;Movement;multilevel analysis;neutralizing antibody;new therapeutic target;Outcome;pandemic disease;Pathway interactions;Peptides;Persons;Play;prevent;Process;Proviruses;receptor;Receptor Activation;receptor binding;Receptor Signaling;Research;Research Personnel;resistance mechanism;Resolution;Resources;response;Role;Series;Signal Pathway;Signal Transduction;Specificity;structural biology;Structure;Surface;Techniques;temporal measurement;Therapeutic;therapeutic target;Time;training opportunity;Vaccination;vaccine development;vaccine response;vaccine trial;Vaccines;Viral;viral rebound;Viral reservoir;Viremia;Virus;Visualization

PROJECT_TITLE: Duke Center for HIV Structural Biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Incarceration disproportionately impacts persons of color and those of low socioeconomic status, groups who are also at high risk for all forms of dementia. By linking administrative data from two national health care systems, we will follow persons age 50 and older to evaluate the relationship between incarceration and dementia over time. Findings from this project will inform strategies to mitigate risk of patients with dementia entering incarceration, will delineate those at highest risk of developing dementia after incarceration, and will identify prime intervention points where optimization of dementia care could reduce health disparities.

PI_NAMEs: BARRY, LISA C;BYERS, AMY LYNN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Affect;Age;age acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Back;Behavioral Model;Black race;Blood Vessels;Capsicum;Characteristics;cohort;Communities;community reentry;contextual factors;Crime;Criminal Justice;Data;Dementia;dementia burden;dementia care;dementia risk;demographics;Diagnosis;disability;Disease;Elderly;emerging adult;Enabling Factors;Enrollment;Environment;Epidemiology;Ethnic Origin;Exclusion;experience;Funding;Generations;Grouping;Health;health disparity;health disparity populations;Health Status;Healthcare Systems;high risk;Hispanic;HIV/AIDS;Homelessness;Imprisonment;Indigenous;Individual;interest;Intervention;Justice;Link;Longitudinal cohort;longitudinal dataset;low socioeconomic status;Medical;Medicare;mild cognitive impairment;Modeling;multidisciplinary;multiple chronic conditions;Not Hispanic or Latino;novel;Outcome;Pathway interactions;Patients;people of color;Persons;Policies;Population;Poverty;Predisposing Factor;Prisons;Probability;profiles in patients;Public Health;Race;Recording of previous events;Reduce health disparities;Research;response;Risk;Risk Factors;risk mitigation;Sampling;severe mental illness;sex;social;socioeconomic disadvantage;Substance Use Disorder;Target Populations;Time;Transitional Care Planning;Unemployment;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Veterans;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Alzheimer’s Disease and Related Dementias in The Most Incarcerated Generation: An Understudied Population with Health Disparities

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: adverse event monitoring;biobank;Clinical Trials;Collection;Communities;Computer software;Data;Data Collection;Data Coordinating Center;data management;data quality;data standards;Databases;Education;electronic data;Ensure;Goals;improved;innovation;International;Medidata;Monitor;Oncology;Patients;Procedures;Process;programs;Publications;Recording of previous events;Reporting;Research;Research Personnel;Retrieval;Secure;Site;software development;Southwest Oncology Group;Specimen;Standardization;statistics;System;tool;Toxic effect;translational medicine;welfare

PROJECT_TITLE: Data Management Core for SWOG SDMC


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Cancer therapy with a combination of cytotoxic drugs and with immune checkpoint inhibitors (ICIs)—agents that reinvigorate the suppressed immune system to attack cancer cells (e.g., anti-PD-1 antibody)—has revolutionized the treatment of metastatic lung cancer, nevertheless, therapeutic resistance is observed in a significant proportion of patients and a critical determinant of unresponsiveness in these patients is the intra- tumoral accumulation of adenosine, a molecule that actively suppresses the effectiveness of immunotherapies. To deplete the intra-tumoral adenosine, we have explored the use of an FDA approved drug, [PEGylated]- Adenosine Deaminase (PEG-ADA). Our proposed studies will confirm if depletion of adenosine with PEG-ADA can induce anti-tumor immunity and sensitize lung cancer to chemo-immunotherapy and such a therapeutic strategy can further extend the life of patient with a disease that is now a major health problem worldwide.

PI_NAMEs: YADDANAPUDI, KAVITHA  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Adenosine;adenosine deaminase;anti-PD-1;anti-PD1 antibodies;Attenuated;cancer cell;Cancer Model;Cancer Patient;cancer therapy;cancer type;Carboplatin;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;chemotherapy;Cisplatin;Clinical;clinically relevant;Combination immunotherapy;Combined Modality Therapy;Cytotoxic agent;Data;Dinoprostone;Disease;Effectiveness;effectiveness testing;effector T cell;Energy-Generating Resources;Enzymes;Epithelial Cells;Eragrostis;extracellular;FDA approved;Generations;Glucose;Health;Human;human disease;humanized mouse;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immuno-Chemotherapy;immunogenic cell death;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;innovation;Inosine;KRASG12D;Life;Lung;Malignant neoplasm of lung;Mediating;Metabolic;Modeling;Molecular;Monoclonal Antibodies;monocyte;mortality;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Nucleotidases;Nutrient;Outcome;Paracrine Communication;Pathway interactions;patient derived xenograft model;Patients;Persons;Pharmaceutical Preparations;Polyethylene Glycols;Polyunsaturated Fatty Acids;Production;programmed cell death ligand 1;programmed cell death protein 1;PTGS2 gene;Purine Nucleosides;randomized, clinical trials;Recombinants;Relapse;Resistance;response;Risk;Sampling;Signal Induction;Signal Pathway;standard of care;Surface;System;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Transgenic Mice;Translating;Treatment Failure;Treatment Protocols;tumor;tumor ablation;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Identifying and targeting a novel mechanism of chemotherapy-induced immunotherapeutic resistance in non-small cell lung cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric;Social Determinants of Health

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Social anxiety disorder is highly prevalent in the United States, most commonly emerging during adolescence. Relationships with a pet dog may support adaptive coping for youth with social anxiety by providing social support, fostering social interactions, and reducing physiological responses to anxiety. Longitudinal research assessing when and how dog relationships can effectively support teenagers with anxiety is critical for maximizing translational impact.

PI_NAMEs: MUELLER, MEGAN KIELY (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;Age;Animals;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxious;Area;Arousal;Attenuated;Behavior;Behavioral;Canis familiaris;childhood anxiety;Clinical;Cognitive;companion animal;Conduct Disorder;coping;Coping Behavior;Coping Skills;Data;design;Development;Early Intervention;Ecological momentary assessment;Emotions;evidence base;evidence based guidelines;experience;Family;Family Relationship;Fostering;Goals;Human;indexing;Individual;Individual Differences;innovation;inter-individual variation;interdisciplinary collaboration;Intervention;Interview;Link;Loneliness;Longitudinal Surveys;Measures;Mental Depression;Mental Health;Mental Health Services;Methods;Nature;negative affect;novel strategies;Outcome;Ownership;Parents;peer;Peripheral;pet animal;Pharmacological Treatment;Physiological;Physiology;Process;Psychology;psychosocial;Research;resilience;response;social anxiety;Social Anxiety Disorder;Social Development;Social Identification;Social Interaction;social stressor;Social support;sociodemographics;Source;Specificity;Substance abuse problem;Sympathetic Nervous System;Teenagers;Time;translational impact;United States;wearable device;Work;wristband;Youth

PROJECT_TITLE: Longitudinal assessment of specificity in adolescent-dog relationships and adaptive coping for youth with social anxiety

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]