ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Narrative Osteoarthritis (OA), a common joint disease, associated with cartilage damages and affecting millions of American every year, currently has no effective cure. While regenerative engineering methods have shown some encouraging results to enhance cartilage healing for the treatment of OA, the use of potentially toxic growth factors in such approaches has limited their application. Here, we propose a new regenerative engineering strategy of employing a biodegradable piezoelectric nanocomposite cartilage-graft and study an optimal exercise to obtain a novel piezoelectric stimulation which can promote healing of cartilages and treat OA in large animals.

PI_NAMEs: NGUYEN, THANH  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Affect;Allografting;American;Analgesics;Animal Model;Animals;Anti-Inflammatory Agents;Area;arthropathies;articular cartilage;Autologous Transplantation;Biocompatible Materials;biodegradable scaffold;Biodegradation;bioelectricity;Biological;bioscaffold;Body Weight;bone;Cartilage;cartilage regeneration;cartilage transplantation;Charge;Chemicals;Clinical;Defect;Degenerative polyarthritis;design;Devices;Disease;Electric Stimulation;Electricity;Electrospinning;Engineering;Environment;Excision;Exercise;Exhibits;Foundations;Frequencies;Grant;Growth;Growth Factor;healing;Human;Immune;Implant;implantable device;In Vitro;Infection;Inflammation;joint loading;Joints;Magnesium Oxide;mechanical properties;Mechanics;Medicine;Methods;Morbidity - disease rate;Motion;nanocomposite;nanofiber;Nanofiber Scaffold;nanoparticle;Natural regeneration;novel;Operative Surgical Procedures;Organism;Oryctolagus cuniculus;Persons;Pharmaceutical Preparations;Physical Exercise;Physiological;Physiology;poly(lactic acid);pressure;Process;Property;reduce symptoms;regenerative approach;Regenerative engineering;research clinical testing;scaffold;Self Stimulation;Sheep;side effect;Signal Transduction;Site;stem cells;Stress;success;Symptoms;Technology;Therapeutic Effect;Time;tissue support frame;Tissues;Toxic effect;Training;treadmill training;United States National Institutes of Health;Work

PROJECT_TITLE: Biodegradable Piezoelectric Nanocomposite Scaffold with Physical Exercise to Heal Major Cartilage Defects in Large Animals

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MAYWOOD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Relevance to Public Health: The proposed research project is focused on the “sodium pump”, an enzyme that transports sodium and potassium across cell membranes. This is a critical function in all cells, and it is carefully regulated by interactions with small proteins that increase or decrease the activity of the pump. By studying how the pump is controlled, we may find new ways to improve its function when it is disrupted in diseases including heart disease, schizophrenia, Parkinson’s disease, and Alzheimer’s disease.

PI_NAMEs: BOSSUYT, JULIE B;ROBIA, SETH L (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Affinity;Alzheimer's Disease;arm;Binding;Binding Proteins;Biochemistry;Biological Assay;Biophysics;Budgets;Cardiac Myocytes;Cell membrane;Cell Physiology;cell type;Cell Volumes;Cells;Chemicals;Chicago;cofactor;Complex;Computer Models;confocal imaging;Cornea;Coupled;Coupling;Development;dimer;Dimerization;Disease;Electrophysiology (science);Engineering;Enzymes;Exercise;experimental study;Failure;Family;feasibility testing;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Foundations;Functional disorder;Gene Delivery;Health;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Human;improved;insight;Ion Transport;K ATPase;Kinetics;Laboratories;Learning;Mass Spectrum Analysis;Measurement;member;Membrane;Membrane Proteins;Methods;Microscopy;Modification;Molecular Conformation;mutant;Na(+)-K(+)-Exchanging ATPase;novel;novel therapeutic intervention;Parkinson Disease;Pathologic;Patients;Peptide Sequence Determination;Peptides;Pharmaceutical Preparations;phospholemman;Phosphorylation;Physiological;Physiological Processes;Physiology;Poison;Post-Translational Protein Processing;Potassium;Process;protein complex;protein degradation;Protein Fragment;protein protein interaction;Proteins;Proteomics;Protomer;Public Health;Pump;Regulation;Research;Research Personnel;Research Project Grants;Sampling;Schizophrenia;Signal Transduction;Site-Directed Mutagenesis;Sodium;structural determinants;Structure;Testing;Texas;Tissues;Translating;Translational Research;Transport Process;Universities;Work

PROJECT_TITLE: The NKA Interactome in Health and Disease

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Asthma;Lung;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative  Mucous metaplasia is commonly seen in acute respiratory illnesses, and is also a characteristic feature of chronic lung diseases including fibrosis, COPD and asthma. Here, we use a combination of mouse models, organoid culture and single-cell analysis to address how abnormal VEGF/KDR signaling contributes to mucous metaplasia. The proposal will provide novel insights into fundamental mechanisms with broad scientific and clinical implications.

PI_NAMEs: QUE, JIANWEN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Address;airway epithelium;airway obstruction;airway regeneration;Alleles;Asthma;asthma model;asthmatic;Cell Differentiation process;Cells;Characteristics;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Data;Development;Disease;Epithelial Cells;Epithelium;epithelium regeneration;Exhibits;Fibrosis;gain of function;Gatekeeping;Genetic;Heterogeneity;Human;in vitro Assay;Infection;Injury;insight;Intestines;KDR gene;Ligands;loss of function;Lung;Lung Diseases;Mediator;Metaplasia;Metaplastic Cell;MHC Class I Genes;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mucus-Secreting Cell;Mus;mutant;Mutation;Naphthalene;Natural regeneration;novel;Organoids;Ovalbumin;overexpression;Pathogenesis;Pathologic;pharmacologic;Pilot Projects;Play;Population;postnatal;Reporter;respiratory;RNA analysis;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;SOX9 protein;stem cells;Testing;therapeutic target;Tissues;unsupervised clustering;Variant;Vascular Endothelial Growth Factors;VEGFA gene;Work

PROJECT_TITLE: VEGF/KDR Signaling in Airway Epithelial Regeneration and Disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAYEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PR CAYEY UNIVERSITY COLL

ORG_STATE: PR

PHR: PROJECT NARRATIVE The U-RISE program at the University of Puerto Rico Cayey (UPR-C) broadens exposure to biomedical science careers, strengthens science identity, enhance scientific information literacy, learning, research, and quantitative and computational skills of undergraduate students by providing cutting-edge research training. These UPR- Cayey students will complete a baccalaureate degree, continue and complete a research-focused higher degree program, and help meet the healthcare needs by discovering the origins and treatments of diseases.

PI_NAMEs: RESTO, WILFREDO  (contact);ROQUE, JOAN ;ROSS, ROBERT G

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Advisory Committees;Area;Bachelor's Degree;Biomedical Research;career;Computational algorithm;Data;Degree program;design;Educational Activities;Educational process of instructing;Educational workshop;Evaluation;evidence base;experience;Exposure to;Faculty;Hispanic;Information Literacy;Laboratory Research;Learning;Learning Module;Literature;Mentors;Monitor;Natural Sciences;Preparation;programs;Puerto Rico;Research;Research Activity;Research Project Grants;Research Training;role model;Science;Scientist;skills;Students;Teacher Professional Development;Training;Training Programs;undergraduate research experience;undergraduate student;Universities;university student;Visit

PROJECT_TITLE: U-RISE at University of Puerto Rico at Cayey

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Life-threatening fungal infections are an escalating problem due, in part, to increasing numbers of immune- compromised individuals and the evolution of drug resistance. Few treatment options exist to combat systemic infections caused by drug resistant pathogens and there is a dire need for new molecular targets to spur novel antifungal drug development. Recent evidence suggests the Cdc14 phosphatase family is an attractive antifungal target and this project will characterize the mechanisms by which Cdc14 regulates virulence-related processes like cell wall integrity, echinocandin drug sensitivity, and hyphal development in the prominent human pathogen Candida albicans.

PI_NAMEs: HALL, MARK C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Active Sites;Alleles;Animals;anti-fungal agents;Auxins;Benign;Binding;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biological Process;C-terminal;Candida albicans;Candida glabrata;Candidiasis;Cell division;Cell Wall;Cells;Clinical;combat;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytokinesis;Data;Defect;design;Development;Disease;Disease Outbreaks;drug development;Drug resistance;drug resistant pathogen;drug sensitivity;Drug Targeting;echinocandin resistance;Enzymes;Evolution;experimental study;Family;Follow-Up Studies;Fungi Model;fungus;Future;Genetic Transcription;Growth;Growth and Development function;Hospitals;human pathogen;Hypersensitivity;Immune;Impairment;Individual;Infection;inhibitor;insight;Life;Link;loss of function;Maintenance;Methods;Mitotic;Modeling;Molecular;Molecular Target;mouse model;mRNA Translation;Multi-Drug Resistance;Mus;Mycoses;novel;Orthologous Gene;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Persons;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Process;Property;Protein phosphatase;Proteomics;Regulation;resistance factors;resistance in Candida auris;Resolution;response;Role;Saccharomyces cerevisiae;Severities;Signal Induction;Signal Transduction;Specificity;Stress;Structure;Substrate Specificity;System;Systemic infection;Tail;Testing;Therapeutic;transcriptomics;Virulence;Virulence Factors;Work;World Health

PROJECT_TITLE: Cdc14 phosphatase - novel roles in drug resistance, virulence, and the response to cell wall stress in fungal pathogens

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Narrative A precise understanding of RAS’ interaction with membranes and trafficking is essential to understand RAS action and to intervene in RAS-driven leukemias. This work uncovers RAB27B GTPase that is crucial to oncogenic NRAS lipid modification, trafficking, signaling and cell growth. It serves the basis for future therapeutic strategies for molecular targeting of various myeloid malignancies.

PI_NAMEs: TONG, WEI  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;Acyltransferase;AGFG1 gene;Biochemical;Biological Assay;CBL gene;CD34 gene;cell growth;Cell Line;Cell membrane;Cells;Cellular Membrane;Chronic Myelomonocytic Leukemia;Collaborations;confocal imaging;cytokine;Cytosol;Data;Development;Disease;Docking;endosome membrane;Family;Future;genetic approach;Genetic Models;Genetic Transcription;Goals;GOLGA7 gene;Grant;Growth;Guanosine Triphosphate Phosphohydrolases;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Imaging Techniques;in vivo;JAK2 gene;Knock-in Mouse;Knockout Mice;leukemia;Leukemic Cell;leukemic transformation;Link;Lipids;live cell imaging;Malignant - descriptor;Mass Spectrum Analysis;Mediating;MEKs;Membrane;Messenger RNA;Modification;Molecular;Molecular Target;mouse genetics;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;novel;Oncogenic;Outcome;palmitoylation;Pathway interactions;Patients;Phenotype;Physiological;Post-Translational Protein Processing;prevent;Prevention;Prognosis;Proteins;rab GTP-Binding Proteins;RAS driven cancer;ras Proteins;Regulation;Role;Signal Transduction;Signaling Protein;Spatial Distribution;stem cell expansion;stem cell growth;stem cell homeostasis;stem cells;Therapeutic;trafficking;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Vesicle;Work;Xenograft procedure

PROJECT_TITLE: Novel Regulation of Oncogenic NRAS Signaling in Myeloid Malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Myeloproliferative Neoplasms (MPN), namely polycythemia vera, essential thrombocythemia and myelofibrosis (MF) are chronic hematologic diseases that arise from a malignant hematopoietic clone and have the potential to progress to more overt phases of MF and MPN-blast phase, which both have limited treatment options and portend a poor prognosis. A subset of MPN patients have an activating mutation and/or overexpression of PPM1D, a serine-threonine phosphatase, which has been implicated in promoting clonal stem cell fitness. This proposal through a multipronged approach utilizing mouse models, patient-derived induced pluripotent stem cell (iPSC) lines and primary specimens from MPN patients will elucidate the role of PPM1D in MPNs and investigate its potential as therapeutic target using a novel PPM1D degrader.

PI_NAMEs: MARCELLINO, BRIDGET KELLY (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Advisory Committees;Apoptosis;Automobile Driving;Biochemical;Biological Assay;Blast Phase;Blood Cell Count;burden of illness;C-terminal;career development;Cell Line;Cell Proliferation;Cells;Chronic;Clinic;clinical phenotype;Collaborations;cytokine;Data;Dependence;Development;Development Plans;Disease;disease phenotype;Disease Progression;DNA Damage;driver mutation;drug development;Drug Targeting;experimental study;fitness;Fostering;Functional disorder;Genes;Genetic Transcription;Genotype;Goals;Grant;Hematological Disease;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic stem cells;Hemorrhagic Thrombocythemia;Histopathology;Human;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;inhibitor;insight;Institution;JAK2 gene;knock-down;Lead;Maintenance;Malignant - descriptor;Manuscripts;MAP Kinase Gene;medical schools;Memorial Sloan-Kettering Cancer Center;Mentorship;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutate;Mutation;Myelofibrosis;Myeloproliferative disease;Natural History;neoplasm therapy;new therapeutic target;novel;novel strategies;overexpression;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Chemistry;Phase;Phosphoric Monoester Hydrolases;Physicians;PI3K/AKT;Polycythemia Vera;Population;Preparation;prevent;professor;Prognosis;programs;Protein phosphatase;Protein Serine/Threonine Phosphatase;PTPN6 gene;Publishing;Research;Resources;response;retroviral transduction;Role;Sampling;Scientist;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Specimen;stem cells;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;Time;TP53 gene;transcriptome;transcriptome sequencing;transplant model;Transplantation;tumor progression;tumorigenesis;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: The Role of PPM1D in Myeloproliferative Neoplasms

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: NARRATIVE Individuals born with malformations in the brain's cerebral cortex suffer from a number of disease phenotypes ranging from mild speech problems to severely debilitating diseases, such as cerebral palsy and uncontrollable epilepsy. Our research goal is to identity new gene mutations that are responsible for causing these malformation diseases, as well as to study the basic blueprints for building a normal cerebral cortex. Further, we will also explore the mechanisms behind a novel cortical malformation disease rooted in ion channel dysfunction, termed “developmental channelopathy”.

PI_NAMEs: SMITH, RICHARD S (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Affect;Area;Behavioral Paradigm;Benchmarking;Biological Assay;Brain;Brain Diseases;brain malformation;Calcium;Candidate Disease Gene;cell cortex;Cell Physiology;Cells;Cementation;Cerebral cortex;Cerebral Palsy;Cerebrum;Clinical;Clinical Data;cohort;consanguineous family;Cortical Malformation;Coupled;Data;de novo mutation;Development;developmental disease;Diagnosis;Disease;disease phenotype;disease-causing mutation;Effectiveness;Electrophysiology (science);Embryonic Development;Epilepsy;exome sequencing;fetal;Fetal Development;Functional disorder;Future;gain of function;Gene Expression Profile;Gene Expression Profiling;Gene Mutation;Genes;Genetic;genetic analysis;genetic approach;genetic disorder diagnosis;Genetic Engineering;genetic testing;genetic variant;Genomics;Goals;Health;Heterogeneity;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;human model;Image;Immunohistochemistry;improved;In Situ;in utero;In Vitro;in vitro Model;in vivo;Individual;innovation;Intellectual functioning disability;Ion Channel;Ions;loss of function;malformation;malformation in cortical development;Methods;Microgyria;migration;Modeling;Molecular;Monitor;mouse model;Mus;Mutate;Mutation;Nature;Nervous System Disorder;neural;neural circuit;Neurobiology;neurodevelopment;neurogenomics;Neurons;neurophysiology;newborn neuron;novel;novel strategies;optogenetics;Organoids;Output;patch clamp;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;pharmacologic;Phenotype;Physiological;Physiology;Population;post-doctoral training;pressure;proband;progenitor;programs;Proliferating;Proteins;Publishing;Pump;Research;Role;segregation;Sensory;Signal Transduction;single-cell RNA sequencing;skills;Sodium Channel;sodium ion;Speech;stem cells;System;Testing;Training;transcriptomics;Transgenic Organisms;Translating;Variant;voltage;Work

PROJECT_TITLE: Role for ion conducting proteins in cortical malformation diseases

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Our overall goal is to develop non-invasive brain stimulation/recording techniques for the human brain that can selectively up- or downregulate a specific connection between two brain areas as well as record the conduction delay and connectivity strength between them. This is useful, because many brain-related disorders reflect net- work-level changes where the connectivity strengths between specific areas have been pathologically reduced or increased. The techniques will be applicable to clinical and research applications in a wide spectrum of neu- rological and psychiatric disorders.

PI_NAMEs: RAIJ, TOMMI  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: addiction;Adult;Animals;Area;Axon;Behavior;behavior prediction;Behavioral;Brain;Cephalic;Clinical;cognitive function;connectome;Data;detection method;Diagnosis;Disease;electric field;Electroencephalography;Etiology;Evoked Potentials;experimental study;Foundations;Frequencies;Future;Goals;Human;improved;indexing;infancy;Injury;innovation;Left;Magnetism;Manuals;Measurement;Measures;Mental Depression;Mental disorders;mental function;Methods;millisecond;Morphologic artifacts;Motor;Motor Cortex;Nervous System Disorder;Neurologic Symptoms;Neuronavigation;Neurons;neurophysiology;noninvasive brain stimulation;novel;Outcome;Outcome Measure;Pathologic;Phase;Physiologic pulse;Physiological;Property;Protocols documentation;psychiatric symptom;Research;response;Role;Route;Signal Transduction;Site;Source;spatiotemporal;Stroke;success;Synapses;Techniques;Testing;Time;Training;Transcranial magnetic stimulation;Traumatic Brain Injury

PROJECT_TITLE: Re-Wiring the Human Brain


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Precision Medicine;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Alzheimer’s disease (AD) and AD-related dementia (ADRD) are increasingly affecting older adults and has no cure. Aerobic exercise has been shown to be a promising treatment in AD/ADRD. but results from previous studies have shown inconsistent cognitive effects due to individual differences and large variations in exercise responses. This trial is the first in AD/ADRD to examine the effect of alternative exercise programs to elicit the best responses in each individual.

PI_NAMEs: YU, FANG  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Adherence;Adult;Aerobic Exercise;Affect;Age;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-42;Amyloid beta-Protein;Animals;Behavioral Symptoms;Biological Markers;Blinded;Blood;Brain;Caregiver Burden;Caregivers;Clinical;Cognition;Cognitive;Communities;cost;Data;Dementia;Distress;Exercise;exercise program;Goals;Human;improved;Individual;Individual Differences;Interval training;Intervention;Light;Magnetic Resonance Imaging;Measures;Mediating;Memory;mild cognitive impairment;Nerve Degeneration;neurofilament;novel;older adult;Outcome;Oxygen Consumption;Participant;Patient-Focused Outcomes;Phase;Physical Function;pilot trial;Plasma;precision medicine;primary outcome;psychological symptom;Quality of life;Randomized;recruit;Reporting;Research;resistance exercise;response;Safety;secondary outcome;Sequential Multiple Assignment Randomized Trial;standard measure;Stretching;tau Proteins;tau-1;Testing;Training;trial design;Variant;White Matter Hyperintensity;Work

PROJECT_TITLE: Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE The Tisch Cancer Institute (TCI) seeks to support the work of Dr. Karyn Goodman, Associate Director of Clinical Research, to foster the growth of our NCI-designated cancer center’s clinical trial program and improve patient access to NCI-sponsored clinical trials across the Mount Sinai Health System. By expanding the clinical trials footprint, the TCI can extend the reach and impact of our high-quality, cutting edge cancer care to the entire catchment area of New York City. Greater access leads to improved equity and inclusion for our diverse patient populations.

PI_NAMEs: GOODMAN, KARYN A. (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Address;Adjuvant;American College of Radiology Imaging Network;Award;Cancer and Leukemia Group B;cancer care;cancer clinical trial;Catchment Area;chemoradiation;Clinical Cancer Center;Clinical Oncology;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Colorado;Development;drug development;Eastern Cooperative Oncology Group;Equity;Faculty;fighting;Fostering;Funding;Funding Mechanisms;gastrointestinal;Goals;Growth;Health system;Hospitals;improved;Institution;Investigational Therapies;investigator-initiated trial;Malignant neoplasm of esophagus;Malignant neoplasm of pancreas;Malignant Neoplasms;Minority Recruitment;National Clinical Trials Network;NCI-Designated Cancer Center;New York City;Oncology;patient population;Patients;phase II trial;phase III trial;Play;Positioning Attribute;Positron-Emission Tomography;Principal Investigator;programs;Radiation Oncology;Radiation Therapy Oncology Group;Research;Resectable;Role;Scientist;Services;Specialist;The University of Colorado Cancer Center;Work

PROJECT_TITLE: NCI Research Specialist (Clinician Scientist) Award


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Genetic Testing;Genetics;Human Genome;Immunotherapy;Patient Safety;Precision Medicine;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The adoption of genomic medicine in the clinic has incredible potential to clarify disease origins, improve diagnosis, and usher in the era of personalized medicine for cancer patients. In this proposal, we plan to provide methods, know how, and robust technologies, in association with clinical trial specimens, for tumor samples to be evaluated for genomic changes that may be targeted by molecular-based therapies.

PI_NAMEs: HAYES, DAVID N;MERKER, JASON DEREK (contact);PEROU, CHARLES M

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Acceleration;Accreditation;Address;Adjuvant Study;Adoption;analysis pipeline;B-Cell Antigen Receptor;Base Sequence;Big Data;Biological Assay;Biological Markers;biomarker development;cancer clinical trial;cancer genome;Cancer Patient;Cells;Center for Translational Science Activities;CLIA certified;Clinic;Clinical;Clinical Data;clinical decision-making;Clinical Trials;Clinical Trials Cooperative Group;clinically relevant;Clonality;Complex;Consultations;cost efficient;Data;data access;Data Analyses;data dissemination;Data Mart;data sharing;data submission;database of Genotypes and Phenotypes;Diagnosis;Disease;DNA;DNA copy number;DNA Sequence;DNA Sequence Alteration;DNA sequencing;exome;experience;Expression Profiling;Formalin;Freezing;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;genome-wide;genomic data;Genomic medicine;Genomics;Genotype;Germ Lines;Goals;Grant;Head;Hereditary Malignant Neoplasm;Human;human subject;human subject protection;Immune;immune cell infiltrate;Immune system;Immunotherapy;improved;Infrastructure;Institution;Laboratories;Laboratory Study;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Massive Parallel Sequencing;Measures;Methods;Molecular Target;mRNA sequencing;Mutation;Mutation Detection;nano-string;National Clinical Trials Network;Neoadjuvant Therapy;neoantigens;next generation;next generation sequencing;novel;Nucleic Acids;open data;Paraffin Embedding;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Ploidies;precision medicine;Precision Medicine Initiative;Predisposition;Privacy;privacy protection;Process;Production;prognostic;receptor;Reproducibility;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Sampling;Science;Selection for Treatments;single-cell RNA sequencing;Specimen;Speed;Staging System;Standardization;Syndrome;T-Lymphocyte;Technical Expertise;Techniques;Technology;The Cancer Genome Atlas;therapeutic enzyme;Time;transcriptome;transcriptome sequencing;Translational Research;tumor;tumor microenvironment;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: UNITS: The UNC / UT National Clinical Trials Network Group Integrated Translational Science Production and Consultation Center


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The project is relevant to public health because it seeks to identify patients at high risk for autoimmune disease and reduce time to autoimmune disease diagnosis and treatment to reduce disease-related morbidity and mortality. The proposed research is relevant to the mission of NIAMS of improving outcomes in patients with systemic autoimmune diseases by identifying which positive ANA patients are at high risk for autoimmune disease and assessing if a risk model in the electronic health record can reduce time to autoimmune disease diagnosis and treatment.

PI_NAMEs: BARNADO, APRIL LYNN (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Antinuclear Antibodies;Artificial Intelligence;Autoimmune Diseases;biomedical informatics;Biometry;Clinical;Clinical Data;clinical decision support;clinical practice;Clinical Research;Clinical Trials;clinically significant;Code;Data;demographics;Diagnosis;Diagnostic;Disease;disease diagnosis;disorder risk;Early Diagnosis;Early treatment;Electronic Health Record;electronic health record system;Evaluation;Face;Fatigue;Future;General Population;Goals;Health;high risk;hospital readmission;implementation science;improved outcome;Infrastructure;innovation;Institution;Laboratories;Logistic Regressions;machine learning method;medical specialties;Mission;Mixed Connective Tissue Disease;Modeling;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;operation;Outcome;patient stratification;Patient Triage;Patient-Focused Outcomes;Patients;Physicians;pre-clinical;Predictive Analytics;predictive modeling;Primary Care Physician;Probability;Provider;Public Health;Randomized;Research;Research Design;Resources;Rheumatology;Risk;Risk Assessment;risk prediction;risk prediction model;risk stratification;Sjogren's Syndrome;Specialist;Strategic Planning;success;support tools;Symptoms;System;systemic autoimmune disease;Systemic Lupus Erythematosus;Systemic Scleroderma;Testing;Time;tool;Translating;treatment as usual;Triage;venous thromboembolism;Wait Time

PROJECT_TITLE: Predicting risk of systemic autoimmune disease in patients with positive antinuclear antibodies

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition that disproportionately affects Veterans. Prolonged Exposure (PE) therapy is a “gold standard” treatment for PTSD. However, approximately one-third of Veterans fail to receive an adequate dose of treatment because they prematurely drop out of PE therapy. There is also room to improve PE treatment outcomes. Consistent with the VA Office of Research and Development initiative to develop effective treatments for PTSD, the proposed randomized clinical trial will examine the ability of oxytocin (as compared with placebo) combined with PE to reduce PTSD symptom severity, improve the rate of PTSD symptom reduction, and to enhance PE treatment retention and adherence. This two-site study will leverage the investments made in the nationwide rollout off PE therapy and has the potential to significantly improve mental health care among Veterans, advance the science in this area, and identify mechanisms underlying positive PTSD treatment response.

PI_NAMEs: FLANAGAN, JULIANNE CHRISTINA (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;adherence rate;Affect;Aggressive behavior;Animals;Anti-Anxiety Agents;Anxiety;Area;Attenuated;Behavior;brain circuitry;Chronic;Chronic Disease;Clinical;Clinical Research;Cognitive Therapy;Collaborations;comorbid depression;Country;Data;depressive symptoms;Diagnostic;disability;Disease remission;Dose;Double-Blind Method;double-blind placebo controlled trial;Dropout;Drops;Economic Burden;effective therapy;efficacy evaluation;efficacy testing;evidence base;Evidence based treatment;experience;Exposure to;Extinction;Family;Feeling suicidal;follow-up;Fright;Functional disorder;Goals;Health;Health Care Costs;health care service utilization;Health Expenditures;Human;Impairment;improved;improved outcome;Individual;Interpersonal Violence;Intervention;Investigation;Investments;Knowledge;learning extinction;Maintenance;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;military veteran;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;neurobiological mechanism;Neurobiology;neuroimaging;Neuropeptides;neuropsychiatry;Occupational;Outcome;Oxytocin;Participant;Patient Care;Patient Dropouts;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacotherapy;phase 2 study;physical conditioning;Physiological;Pilot Projects;Placebo Control;Placebos;Post-Traumatic Stress Disorders;pre-clinical research;premature;prognostic indicator;psychosocial;Public Health;Qualifying;Randomized;randomized controlled design;randomized, clinical trials;Randomized, Controlled Trials;reduce symptoms;Research;research and development;response;retention rate;Risk;Safety;Science;Severities;Site;Sleep;social;social cognition;standard care;Standardization;Stress;Substance abuse problem;suicidal;symptomatic improvement;symptomatology;Symptoms;Time;Training;Treatment outcome;treatment response;treatment services;Trust;Veterans;Veterans Health Administration

PROJECT_TITLE: Enhancing Prolonged Exposure Therapy for PTSD with Oxytocin


FUNDING_MECHANISM: OTHERS

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: PTSD is common among Veterans with serious mental illness (SMI). Co-occurring PTSD and SMI lead to poorer mental health and physical functioning than either diagnosis alone and is a critical obstacle to rehabilitation and recovery. Despite known high prevalence rates of PTSD in SMI populations as well as disparities in prevalence and treatment use for Black, Indigenous, and other people of color (BIPOC), little research has been done to: a) evaluate leading treatments for PTSD in individuals with SMI, and b) develop culturally responsive methods to integrate with PTSD treatments for SMI Veterans. This study aims to address research and clinical gaps by: a) testing the feasibility and acceptability of Written Exposure Therapy (WET), a VA evidence-based psychotherapy for PTSD in Veterans with SMI, and b) incorporating culturally responsive assessment methods. Results from this study will inform whether WET and culturally responsive assessment are feasible to implement, acceptable to Veterans with SMI, and worth examining in standard or optimized form in a larger clinical trial.

PI_NAMEs: HOWELL, MARY KATHERINE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Aftercare;Area;Assessment tool;Bipolar Disorder;Black race;brief intervention;career;career development;Caring;Characteristics;Chronic;Clinic;Clinical;Clinical Trials;cognitive capacity;contextual factors;Data;Diagnosis;Disease;Disparity;Dropout;Education;Equity;equity, diversity, and inclusion;ethnic disparity;ethnic minority;Evaluation;evidence base;Evidence based practice;Exclusion;Exhibits;experience;feasibility testing;follow-up;Formulation;functional improvement;functional outcomes;Future;Goals;Healthcare;High Prevalence;Impaired cognition;Impaired health;Improve Access;improved;Indigenous;Individual;instrument;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lead;Measures;Mental disorders;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Minority;Monitor;Outcome;Participant;Patient Self-Report;people of color;physical conditioning;Physical Function;Pilot Projects;pilot test;Population;Post-Traumatic Stress Disorders;Prevalence;process evaluation;programs;Protocols documentation;psychoeducation;Psychotherapy;psychotic;Quality of life;Questionnaires;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;Recovery of Function;recruit;rehabilitation research;Rehabilitation therapy;Research;research and development;Research Personnel;response;satisfaction;severe mental illness;Severities;skills;Specific qualifier value;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;Therapy trial;Training;Trauma;Treatment Efficacy;Treatment outcome;treatment trial;Veterans;Veterans Health Administration;Writing

PROJECT_TITLE: PTSD Treatment for Veterans with Serious Mental Illness to Improve Functional Outcomes

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The placenta has a complex vascular structure that balances maternal supply of oxygen and nutrients to fetal demand. The objective of this proposal is to implement and validate a multi-modal magnetic resonance imaging approach to comprehensively study maternal and fetal-side placental perfusion characteristics in a translational animal model. This will enable the development of tools to identify pregnancies at-risk of placental insufficiency and facilitate future clinical diagnostic and management strategies.

PI_NAMEs: MELBOURNE, ANDREW ;ROBERTS, VICTORIA HJ (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Achievement;adverse outcome;Animal Model;Blood;Blood flow;Blood gas;Blood Vessels;Blood Volume;Characteristics;Chronic;Circulation;Clinical;clinical application;clinical diagnostics;Clinical Management;clinically relevant;Collaborations;Complex;Computer Models;contrast enhanced;Coupling;Data;data acquisition;data analysis pipeline;data modeling;Decidua Basalis;Dependence;Detection;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Early identification;fetal;fetal blood;Fetal Development;Fetal Growth Retardation;Fetoplacental Circulation;Fetus;fetus hypoxia;Future;Health;hemodynamics;Human;human study;Image;imaging approach;imaging biomarker;imaging capabilities;imaging modality;improved;in utero;in vivo;Individual;Injury;interest;Lateral;Left;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;member;Methodology;Methods;Modeling;multimodal modeling;multimodality;Nervous System Trauma;nonhuman primate;novel;Nutrient;obstetric outcomes;offspring;Oxygen;oxygen transport;Perfusion;Physiological;Physiology;Placenta;Placental Circulation;Placental Insufficiency;Placentation;Positioning Attribute;Pre-Eclampsia;Pregnancy;pregnant;Premature Labor;prevent;Primates;Property;quantitative imaging;Relaxation;Research;response;Risk;Role;Sheep;Side;statistics;stillbirth;Structure;Structure of placental cotyledon;Study Subject;Supination;Techniques;Tissues;tool;tool development;Translating;Validation;Variant;Waste Products;Work

PROJECT_TITLE: Development and validation of MR imaging methods for in vivo assessment of placental perfusion and oxygen transport


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vector-Borne Diseases

ORG_NAME: PORTLAND STATE UNIVERSITY

PHR: PROJECT NARRATIVE  Malaria remains one of the deadliest diseases in the world today and accounts for over 200 million clinical cases worldwide each year along with roughly half a million deaths, mostly children under the age of five and pregnant women. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need and continuous search for novel, affordable, and safe drugs for prevention and treatment of malaria. We have developed a novel antimalarial acridone chemotype that is potent against both blood stage and liver stage malaria parasites, with single-dose cure ability and potential to prevent relapsing infection, that warrant further preclinical development.

PI_NAMEs: KELLY, JANE X (contact);ROTH, ALISON ELIZABETH

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Age;Anti-malarials;Biological Assay;bioluminescence imaging;Blood;Caco-2 Cells;Cessation of life;chemical synthesis;Child;Clinical;combat;Cytochrome P450;cytotoxicity;Development;Disease;DNA analysis;Dose;Drug Interactions;Drug Kinetics;Drug resistance;Electron Transport;Generations;genome analysis;genome sequencing;Genomic DNA;Glucosephosphate Dehydrogenase Deficiency;Goals;Hepatocyte;Human;improved;In Vitro;in vivo;Individual;Infection;Isoenzymes;iterative design;Lead;lead candidate;lead optimization;Liver;Liver Microsomes;Malaria;malaria infection;Metabolic;metabolic profile;Microsomes;Mitochondria;Modeling;Molecular;Molecular Target;Mus;nonhuman primate;novel;Parasite resistance;Parasites;Patients;Permeability;Pharmaceutical Preparations;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Plasmodium yoelii;preclinical development;preclinical evaluation;preclinical safety;Preclinical Testing;Pregnant Women;prevent;Prevention;process optimization;Relapse;relapse prevention;Research;Resistance;Rodent;Rodent Model;Safety;safety assessment;Series;Solubility;Sporozoites;Time;tool;Toxic effect;Toxicity Tests;vaccine access;Validation;Vulnerable Populations;whole genome

PROJECT_TITLE: Second-Generation Novel Liver Stage Active Antimalarials

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Schizophrenia

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This proposal aims at elucidating the molecular mechanisms of astrocyte-based neuromodulation, and the causal role of this form of signaling in cognitive functions and in the behavioral effects of cognitive enhancers. Success in this research program will identify new operating principles that govern input-output fidelity in astrocytes, which will be applicable to many pathways. In addition, defining a tractable relationship between astrocyte signaling and cognitive behavior, and its activation by clinically tested therapeutics, will establish a new benchmarks for considering astrocyte biology in the treatment of cognitive disabilities and mental disorders.

PI_NAMEs: PAPOUIN, THOMAS  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Ablation;Adult;Agonist;alpha-bungarotoxin receptor;Astrocytes;Behavior;Behavioral;behavioral outcome;Benchmarking;Binding;Biology;Brain;Brain Diseases;cell type;Cells;Characteristics;cholinergic;Clinical;Clinical Treatment;Clinical Trials;Code;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive disability;cognitive enhancement;cognitive function;Coupling;Cues;Data;Dose;drinking water;drug development;Electron Microscopy;Environment;excitatory neuron;Failure;FDA approved;Fluorescence;Genetic;Human;imaging study;Impaired cognition;in vivo;inhibitory neuron;Intervention;Knockout Mice;Ligands;Light;Link;Maps;MATRICS Consensus Cognitive Battery;Measures;Mediating;Mental disorders;Mental Health;Modality;Molecular;Morphology;Mus;nanoscale;National Institute of Mental Health;Nervous System Disorder;neural circuit;Neurobehavioral Manifestations;Neuroglia;Neurons;Neurophysiology - biologic function;neuroregulation;Nootropic Agents;Output;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase III Clinical Trials;Pilot Projects;Positioning Attribute;Process;programs;Quantum Dots;receptor;Research;response;Role;Route;Schizophrenia;Seminal;Serine;Shapes;Signal Transduction;sobriety;stimulant use;success;Surface;Synapses;Testing;Therapeutic;therapeutic evaluation;Work

PROJECT_TITLE: Role of astrocyte-based cholinergic neuromodulation in cognition and in the treatment of cognitive disorders

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Loss of function mutations in MeCP2 cause Rett syndrome (RTT), a leading monogenetic neurodevelopmental disorder with a hallmark of progressive loss of acquired motor and cognitive skills. Recent work in our lab has found that Mecp2-null mice are still capable of developing motor skills, and that this motor learning benefits the mice in other domains. This proposal will deepen our understanding of motor cortical function at the circuit level in both mutant and wild-type animals.

PI_NAMEs: LU, HUI  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Affective;Animals;Anxiety;anxiety-like behavior;Attenuated;Behavior;Birth;Brain;Calcium;cell type;Child;Cognitive;cognitive skill;computerized;Data;Development;Disease;Empathy;Female;Fiber;flexibility;Foundations;Functional disorder;Genes;girls;Heterozygote;Human;Image;improved;Individual;inhibitory neuron;insight;juvenile animal;Knockout Mice;Language;Learning;Learning Skill;Life;Link;loss of function mutation;male;Manuscripts;Memory;Methyl-CpG-Binding Protein 2;Motor;motor control;Motor Cortex;motor disorder;motor function improvement;motor learning;motor skill learning;Motor Skills;Mus;mutant;Mutant Strains Mice;Natural History;Nature;Neurodevelopmental Disorder;Neurons;Onset of illness;Phenotype;Population;Population Decreases;postnatal;Primates;Process;response;Rest;Rett Syndrome;Running;Short-Term Memory;skill acquisition;skills;social;Social Interaction;somatosensory;Speed;Subgroup;Synapses;Time;Training;two-photon;Wild Type Mouse;Work

PROJECT_TITLE: Understanding the effects of motor learning in wild-type and Mecp2-deficient mice

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: BASTARACHE, JULIE ANNE (contact)

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Active Learning;Advisory Committees;Area;Award;bench to bedside;Biology;Biometry;career;career development;Clinic;Clinical;Communities;Competence;data management;Data Science;Dedications;Disadvantaged;Discipline;Disease;Educational Status;Educational workshop;Epidemiology;Ethnic Origin;experience;flexibility;Fostering;Funding;Future;Gender;Graduate Education;Grant;Health;Healthcare Systems;Hour;Individual;Learning;Libraries;Measurement;Medical center;meetings;Mentors;Mentorship;Methods;Modeling;Monitor;National Research Service Awards;next generation;Pathway interactions;peer coaching;Postdoctoral Fellow;pre-doctoral;programs;Race;Research;Research Personnel;Resource Sharing;Science;sex;Site;Structure;Study Section;synergism;technological innovation;Technology Transfer;Time;TNFSF15 gene;tool;Training;Training Programs;Translational Research;translational scientist;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative / Relevance Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. We propose to expand the work of the PGC so we can learn key lessons about the fundamental basis of major psychiatric disorders

PI_NAMEs: ANDREASSEN, OLE A;HUCKINS, LAURA MARIANNE;IYEGBE, CONRAD ;MULLINS, NIAMH  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;base;biobank;Biological;Biology;Biotechnology;career;case control;Cells;Clinical;Collaborations;Communication;Communities;Country;Data;Diagnostic;digital media;Disease;DNA Resequencing;education resources;Educational Materials;Ensure;Epidemiology;exome;exome sequencing;experimental study;Facebook;Family;Fostering;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;Genets;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;improved;Individual;Industry;innovation;insight;Institution;instrument;Investments;Journals;Knowledge;Learning;Life;Maps;Measures;Medical;Medicine;Mendelian randomization;Mental disorders;Meta-Analysis;Methods;Mission;Modeling;Molecular;National Institute of Mental Health;Nature;Neurosciences;novel;novel therapeutics;Outcome;outreach;Paper;patient stratification;patient subsets;Patients;Phase;Phenotype;predict clinical outcome;Productivity;Psychiatric Diagnosis;psychiatric genomics;Psychiatry;rare variant;Recording of previous events;Reproducibility;Research Personnel;Resistance;Resources;Risk;Risk Factors;Science;Scientist;severe psychiatric disorder;Source;statistics;success;Symptoms;Therapeutic;therapeutic development;Time;translational potential;Twitter;Update;Variant;whole genome;Work;working group

PROJECT_TITLE: 3/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Pediatric;Social Determinants of Health

ORG_CITY: Akron

ORG_NAME: CHILDREN'S HOSPITAL MED CTR OF AKRON

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because therapeutic advances have changed acute illnesses with high child mortality into chronic diseases that children, adolescents, and young adults may live with well into their fourth decade. There is a significant need to define quality domains inclusive of all stakeholders’ perspectives on symptom management and quality of life, to further future practice guideline development, health outcome and quality improvement studies helping children and adolescents live well with significant conditions. Thus, the proposed research is relevant to multiple parts of NIH’s mission, particularly through NINR, that pertain to i) enabling rapid translation of needs and best practices for the integration of palliative care into home and community settings; ii) addressing social and environmental factors affecting end-of-life and palliative care; and iii) considering the environment and unique needs of each patient to facilitate high-quality end-of-life and palliative care.

PI_NAMEs: GROSSOEHME, DANIEL HUCK (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Acute;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Ambulatory Care Facilities;Benchmarking;Bereavement;care delivery;care providers;care systems;Caregivers;Caring;Cessation of life;Characteristics;Child;Child Care;Child Mortality;child services;Childhood;Chronic Disease;Clinical Practice Guideline;clinically significant;Collaborations;community setting;Consensus;Continuity of Patient Care;Data;Data Set;data sharing;Decision Making;design;Development;Dimensions;disability;Dissemination and Implementation;end of life;end of life care;Environment;Environmental Risk Factor;European;experience;Family;Family Caregiver;Female;Focus Groups;Future;Gender;Geography;Goals;Guidelines;Health;Heterogeneity;Home;Hospice Care;Hospitals;improved;innovation;Inpatients;Interview;Knowledge;Language;Life;low socioeconomic status;Mission;Modeling;novel;Ohio;Outcome;Outcome Measure;palliative;Palliative Care;Parents;Patient Outcomes Assessments;Patients;pediatric patients;pediatrician;personalized care;Persons;Population;Practice Guidelines;Process;Program Development;Program Evaluation;prospective;Provider;Psychosocial Assessment and Care;Public Health;Quality of Care;Quality of life;Race;Research;Research Personnel;Research Priority;Rural;Sampling;Science;Service provision;sexual minority;Site;social factors;Spirituality;stakeholder perspectives;Structure;symptom management;Therapeutic;Translations;United States National Institutes of Health;Voice

PROJECT_TITLE: Integrating clinician, caregiver and patient prioritized quality domains for home-based pediatric hospice and palliative care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition;Physical Activity;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Physical inactivity is prevalent, costly, and deadly, particularly among individuals with cardiometabolic conditions. While mind-body exercise interventions (e.g., yoga, tai chi), which include several therapeutic components (e.g., physical exercise, mindful attention), are promising for improving physical activity levels, it is difficult to optimize these interventions for physical activity promotion without understanding the effects of these core components on health behavior change processes. Using metabolic syndrome as a model, this project will assess the feasibility and acceptability of a factorial design that examines the effects of two mind-body exercise components, exercise and mindful attention, on key health behavior change processes.

PI_NAMEs: KRAEMER, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;Adherence;Affect;Area;Attention;Awareness;Behavior;behavior change;Breathing;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiopulmonary;Cardiopulmonary Physiology;cardiovascular risk factor;career;Clinical Research;Clinical Trials Design;cost;Data;Data Analyses;design;Development;Dimensions;Disease;Doctor of Philosophy;emotion regulation;Enrollment;Exercise;exercise intensity;exercise intervention;Feedback;Focus Groups;Fostering;Foundations;Future;Goals;Guidelines;Health behavior;Health behavior change;Health Benefit;Health Promotion;Heart Rate;heart rate variability;improved;indexing;Individual;Informal Social Control;Institution;Intervention;Lead;Logistics;Mediation;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic syndrome;Methods;mind/body;mindfulness;Modeling;multimodality;National Center for Complementary and Integrative Health;Patients;Pattern;Physical activity;Physical Exercise;physical inactivity;Physiological;Physiology;Pilot Projects;Population;preference;Procedures;Process;Protocols documentation;Qualitative Research;Randomized;Research;Research Design;Research Personnel;Resources;sedentary;Self Efficacy;skill acquisition;symposium;Tai Ji;Testing;Therapeutic;Time;Training;treadmill;Work;Yoga

PROJECT_TITLE: Understanding components of mind-body exercise for physical activity engagement in metabolic syndrome


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Breast cancer is the most frequently diagnosed women’s cancer (271,270 estimated new cases diagnosed in 2019) and even in the wake of novel treatment regimens and revised screening criteria, it remains a leading cause of cancer death among women, predominately due to malignant transformation and treatment resistance. Analyzing patient blood samples for genomic disturbances, such as gene fusion products involving the estrogen receptor, would be both more efficient and accessible for patients at risk of metastases and for monitoring development of treatment resistance in those already diagnosed with late-stage breast cancer. The proposed study will utilize molecular techniques, breast cancer models, including a patient derived xenograft, and clinical samples to examine the functionality, structure-function relationship and prevalence of gene fusions as well as analyze the feasibility of extracting gene fusion products from liquid biopsy isolated exosomal RNA that could ultimately lead to improved diagnosis, outcomes and treatment guidance.

PI_NAMEs: YATES, MEGAN  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: advanced breast cancer;alternative treatment;Aromatase Inhibitors;Binding;Biological Markers;Biology;Biopsy Specimen;Blood;Blood specimen;Breast Cancer Cell;Breast Cancer cell line;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Cancer Cell Growth;Cancer Etiology;Candidate Disease Gene;Categories;cell growth;Cell Line;Cell Proliferation;Cells;Cessation of life;Chimeric Proteins;ChIP-seq;Clinical;Clinical Management;clinically relevant;clinically significant;Collection;Controlled Clinical Trials;Data;Death Rate;Detection;Development;Diagnosis;Dimerization;Disease;Disease Progression;DNA Sequence Alteration;Endocrine;ESR1 gene;Estrogen Antagonists;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;Exhibits;exosome;fusion gene;Gene Fusion;gene product;gene translocation;Genes;Genetic Transcription;Genomics;Goals;Growth;Hormonal;hormone therapy;Human;improved;In Vitro;in vitro testing;in vivo;innovation;Invaded;Investigation;Ligand Binding Domain;Ligands;liquid biopsy;Lung;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Metastatic breast cancer;metastatic process;Metastatic/Recurrent;migration;Modality;Modeling;Molecular;Monitor;Monitoring Clinical Trials;mortality;Mutagenesis;Mutation;Nature;Neoplasm Metastasis;novel;Outcome;Pathway interactions;patient derived xenograft model;Patients;Persons;Phase II Clinical Trials;Phenotype;Point Mutation;Prevalence;Prevalence Study;Prognosis;Progression-Free Survivals;Property;Randomized;receptor;Refractory Disease;Regimen;Relapse;Research Personnel;Resistance;Resistance development;response;Risk;RNA;Role;Sampling;screening;Selective Estrogen Receptor Modulators;Signal Pathway;Signal Transduction;stem;Structure-Activity Relationship;Survival Rate;Techniques;therapy development;therapy resistant;Training;transcription factor;transcriptome;transcriptome sequencing;Transfection;Translational Research;Treatment Protocols;treatment strategy;tumor;tumor progression;women's diagnosis;Women's mortality

PROJECT_TITLE: Functional Characterization and Clinical Prevalence of ESR1 Fusions in Advanced Endocrine Resistant Breast Cancer


ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The goal of this project is to continue the development and implementation of a training program designed to encourage and enable undergraduate students from under-represented and disadvantaged backgrounds to pursue biomedical research careers in areas related to heart, lung or blood pathophysiology. Our program was developed on the premise that the principal barrier to diversity in science is not a lack of talent, but rather a lack of opportunity. Thus, our program was built around an intensive research experience with an individual mentor, complemented by activities important to building communication and networking skills, such as making presentations in journal club and at a closing poster session, as well as seminars and workshops that address issues relevant to career-building in biomedical sciences.

PI_NAMEs: DAMARLA, MAHENDRA ;SHIMODA, LARISSA A. (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Academia;Address;Admission activity;Advisory Committees;Area;Award;Behavioral Sciences;Biomedical Research;Blood;career;Clinical Research;cohort;Communication;Complex;Critical Care;design;Development;disadvantaged background;education pathway;Education Projects;Educational workshop;Enrollment;Environment;Exhibits;experience;Exposure to;Faculty;Fellowship;Foundations;Functional disorder;Funding;Goals;Government;graduate school;Health;Heart;improved;Individual;Industry;Institution;Interview;Journals;Length;Lung;Medical;medical schools;Medicine;member;Mentors;Modeling;National Heart, Lung, and Blood Institute;Participant;Pathway interactions;Persuasive Communication;Physicians;Play;Positioning Attribute;posters;Process;programs;Publications;Publishing;recruit;Research;Research Personnel;Research Training;Review Literature;Role;role model;Running;Scholarship;Science;Scientist;skills;student mentoring;student participation;Students;success;summer research;Talents;Training;Training Programs;undergraduate student;Underrepresented Students;young man;young woman

PROJECT_TITLE: Short-Term Training Program to Increase Diversity in Health-Related Research


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Nutrition;Regenerative Medicine

ORG_NAME: MONELL CHEMICAL SENSES CENTER

PHR: PUBLIC HEALTH RELEVANCE Taste loss contributes to malnutrition, depression, and reduced quality of life in affected patients. In this project, we will investigate the role of inflammation in taste loss using both a transgenic approach and a respiratory viral infection model. Our goal is to characterize the relationship between inflammation, taste loss, and taste bud regeneration to provide mechanistic insights for future therapies aimed at correcting or preventing immune-related taste dysfunction.

PI_NAMEs: WANG, HONG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Affect;Ageusia;Animal Model;Autoimmune Diseases;Autoimmunity;Body Weight decreased;Cell Death;Cell Death Induction;Cells;clinically relevant;COVID-19;COVID-19 patient;cytokine;Diagnosis;Disease;disease model;effective therapy;Epithelium;Event;Exhibits;experience;Functional disorder;Future;Goals;Health;High Prevalence;Immune;immune activation;immune cell infiltrate;Immune system;Infection;Infiltration;Inflammation;Inflammation Process;Inflammatory;Inflammatory Response;influenza infection;influenzavirus;Injury;insight;Interferon Gamma Receptor Complex;Interferon Type II;Invaded;Investigation;Knowledge;Link;Malnutrition;Mediating;Mental Depression;Modeling;Molecular;Mouse Strains;Mus;Natural regeneration;novel strategies;pathogen;Pathogen detection;Pathway interactions;Patients;Perception;Play;Positioning Attribute;prevent;Prevention;Process;public health relevance;Quality of life;Reaction;receptor;Receptor Cell;Recovery;Research;Research Personnel;Resolution;Respiratory System;respiratory virus;response;Role;SARS-CoV-2 infection;Sensory;Signal Pathway;Signal Transduction;Signaling Molecule;stem cells;Symptoms;Taste Bud Cell;Taste Buds;Taste Disorders;Taste Perception;Testing;tissue regeneration;tissue repair;Tissues;Toll-like receptors;tongue papilla;Transgenic Mice;Transgenic Organisms;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Mechanisms of inflammation-triggered taste loss and its recovery

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Patient Safety

ORG_CITY: SAN JOSE

ORG_NAME: SAN JOSE STATE UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Antibacterial resistance is an urgent public health threat, particularly in hospital-acquired infections from bacteria like Pseudomonas aeruginosa where few treatment options exist. Cationic antimicrobial peptides (CAPs) are currently used as last resort treatments for infections with multidrug-resistant P. aeruginosa, but CAP- resistant strains have been encountered. The proposed research aims to develop and characterize small molecule inhibitors that block the CAP-resistance pathway for use as a combination therapy with a CAP to clear infections with CAP-resistant P. aeruginosa.

PI_NAMEs: MILLER CONRAD, LAURA C. (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acute;Adjuvant;Adjuvant Study;Adjuvant Therapy;analog;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Cationic Peptides;Arabinose;Area;aspirate;Bacteria;Bacterial Drug Resistance;Bacterial Infections;bactericide;Binding;Biological Assay;Calorimetry;carbapenem-resistant Enterobacteriaceae;Carboxy-Lyases;career;Charge;Clinic;Colistin;colistin resistance;Combined Modality Therapy;Complement;COVID-19 pandemic;current pandemic;Development;Disease Outbreaks;Dose;Drug resistance;effective therapy;Effectiveness;Electrostatics;Ensure;Enzymes;experimental study;Foundations;Funding;Future;Goals;Gram-Negative Bacteria;Hospitalization;Hospitals;Infection;inhibitor;Kinetics;Legal patent;Life;Lipid A;Lipids;Longitudinal Studies;Mass Spectrum Analysis;Mediating;Membrane;Microbial Biofilms;Modification;Molecular Mechanisms of Action;Molecular Target;Motivation;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;mutant;Nosocomial Infections;novel therapeutic intervention;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;post SARS-CoV-2 infection;Predisposition;prevent;Privatization;Pseudomonas aeruginosa;Public Health;Research;Resistance;Resistance development;resistant strain;Salmonella;Sampling;SARS coronavirus;Science;secondary infection;Serial Passage;Severe Acute Respiratory Syndrome;side effect;Signal Pathway;small molecule inhibitor;Source;Testing;Therapeutic;Therapeutic Index;Time;Titrations;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Work

PROJECT_TITLE: Blocking Cationic Antimicrobial Peptide-Resistance in Pseudomonas aeruginosa


NIH_SPENDING_CATS: Clinical Research;Data Science;Emergency Care

PROJECT_TERMS: Active Learning;Advisory Committees;Anesthesiology;Area;Automobile Driving;Biology;Biometry;career;career development;Case Study;Chemistry;Clinical;Communication;Communities;Competence;Consultations;Data Science;Dedications;design;Disadvantaged;Discipline;Discipline of Nursing;Doctor of Philosophy;early-career faculty;Educational workshop;Elements;Emergency Medicine;Ensure;Environment;Epidemiology;Ethnic Origin;Evaluation;Exposure to;Fostering;Funding;Gender;Goals;Grant;Health;Healthcare Systems;Hearing;Individual;innovation;Institution;interdisciplinary approach;Lead;Learning;Libraries;Manuscripts;Measurement;Medicine;Mentors;Mentorship;Methods;next generation;Pathway interactions;Pediatric Surgical Procedures;Problem Solving;programs;Race;Reproducibility;Research;Research Design;Research Personnel;Resources;responsible research conduct;Science;Scientist;sex;Site;Speech;Structure;Study Section;technological innovation;Technology Transfer;Thoracic Surgical Procedures;Time;tool;Training;Translational Research;translational scientist;Writing

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative In the last five decades, the great strides made in biomedical research has made training the next generation of physician scientists a critical element needed to translate biomedical discoveries into new therapies capable of treating and preventing human disease. The goal of the T35 NIAAA Summer Research Program is to identify highly-qualified pre-doctoral students and educate them to pose scholarly questions and design methods of answering those questions to continue to advance the science of medicine through a mentored research experience and in-class educational opportunities.

PI_NAMEs: BROWN, E SHERWOOD  (contact);ENGELKING, LUKE JAMES

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Alcohol abuse;alcohol effect;Alcoholism;Area;Biomedical Research;Clinic;Clinical;Country;Educational process of instructing;Elements;Enrollment;experience;Faculty;Funding;Grant;interest;Journals;Laboratories;Medical center;medical schools;Medical Students;Mentors;National Institute on Alcohol Abuse and Alcoholism;Program Description;programs;Psychiatry;Research;Research Activity;Research Methodology;Research Training;Resources;Series;Students;summer research;training opportunity;Training Programs;United States National Institutes of Health;Work

PROJECT_TITLE: T35 NIAAA Summer Research Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  This project will conduct the 2021 wave of the Child Development Supplement (CDS) to the Panel Study of Income Dynamics (PSID). CDS-21 will collect follow-up interviews of children's primary caregivers (typically mothers) and of older children (ages 12–17 years in 2021) who participated in the 2019 wave of CDS. This new wave of CDS in 2021 will, in conjunction with data from earlier CDS waves, provide unique and valuable prospective panel data to study the effects of the Covid-19 pandemic, lockdown, and recession on children's health, family circumstances, schooling, development, and well-being.

PI_NAMEs: SASTRY, NARAYAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adult;African American population;Age;aged;Behavioral;Birth;Caregivers;Characteristics;Charge;Child;Child Development;Child Health;Child Rearing;Childhood;cohort;COVID-19;COVID-19 impact;COVID-19 outbreak;COVID-19 pandemic;COVID-19 pandemic effects;Data;data centers;Data Collection;design;Development;Documentation;Economic Recession;Economics;Education;Eligibility Determination;experience;Exposure to;Family;Family dynamics;Family member;Financial Hardship;follow-up;food insecurity;Generations;Goals;grandparent;Health;Health behavior;Household;human capital;Immigrant;Immigrant family;Individual;insight;Interview;Life Cycle Stages;Link;Living Arrangement;Longitudinal Surveys;Measures;media use;member;Mothers;Neighborhoods;next generation;Outcome;pandemic impact;panel study of income dynamics;Personal Satisfaction;Policies;Poverty;primary caregiver;Process;prospective;Research;Research Personnel;Research Support;Resources;Sampling;SARS-CoV-2 exposure;Schools;Siblings;social;social capital;social science research;Social Well-Being;statistics;Technology;Time;transition to adulthood;United States;welfare

PROJECT_TITLE: Covid-19 Effects on Children & Families: 2021 Follow-Up of the PSID Child Development Supplement

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The goal of this proposal is to understand how the self-assembly of molecular bio-polymers gives living cells their shape; helps them to organize their contents; and enables them to move. This is important because it will help us to understand the mechanisms underlying many pathological conditions, including: developmental defects, cancer metastasis, immune cell malfunction, and viral infection.

PI_NAMEs: MULLINS, R DYCHE (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Assembly and function of cytoskeletal systems in eukaryotic and prokaryoticcells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Bacterial infections simultaneously activate several innate immune responses with beneficial but also deleterious effects on the host. The present grant proposal aims at clarifying beneficial and deleterious responses triggered by caspase-11 in epithelial or endothelial cells focusing on their role in eicosanoid synthesis and coagulation. Our studies will potentially facilitate development of therapeutic interventions to encourage the protective responses and inhibit the deleterious ones.

PI_NAMEs: RE, FABIO C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: alveolar epithelium;Anti-Inflammatory Agents;Applications Grants;Attention;Bacterial Infections;Bone Marrow;Burkholderia pseudomallei;CASP1 gene;Caspase;Cell Death;cell type;Cells;Coagulation Process;Cytoprotection;Dinoprostone;Disseminated Intravascular Coagulation;Eicosanoid Production;Eicosanoids;Endemic Diseases;Endothelial Cells;Endotoxic Shock;Epithelial Cells;Epithelium;Far East;Gram-Negative Bacteria;IL18 gene;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Interleukin-1 beta;Leukotriene B4;Literature;Lung;Lytic;Mediating;Melioidosis;Modeling;mouse model;Mus;Myeloid Cells;pathogen;Pathogenesis;pharmacologic;Phospholipase A2;Platelet Activating Factor;Play;Predisposition;Production;Prostaglandins;PTGS1 gene;PTGS2 gene;Publishing;radioresistant;reconstitution;Reporting;response;Role;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Thromboplastin;Thromboxanes

PROJECT_TITLE: Role of non-myeloid cells' pyroptosis in melioidosis

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Variants in genes encoding multiple subunits of the BAF chromatin remodeling complex are a cause of genetic neurodevelopmental disorders. The BAF complex has been shown to interact with Fos, a major activity- dependent transcription factor known to be important in neurodevelopmental processes, but how Fos and the BAF complex regulate neuronal activity-dependent genetic programs remains unclear. This project will study the role of Fos and the BAF complex in regulating activity-dependent processes and how these are perturbed in a model of BAF-related neurodevelopmental disease.

PI_NAMEs: TROWBRIDGE, SARA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Advisory Committees;Affect;Animal Model;Area;autism spectrum disorder;behavioral phenotyping;Binding;Binding Sites;Brain;brain abnormalities;career;career development;cell type;Cells;Childhood;childhood epilepsy;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Collection;Complex;CRISPR/Cas technology;Data;dbSNP;design;Development;developmental disease;Developmental Process;Disease;disease model;Distal;Distal Enhancer Elements;Enhancers;Epilepsy;Ethics;Exhibits;experimental study;Fibroblasts;Functional disorder;Gene Expression;Genes;Genetic;Genetic Databases;Genetic Transcription;genetic variant;Genetic Variation;Genomics;Germ Lines;Heterozygote;Human;Human Activities;human disease;human embryonic stem cell;human embryonic stem cell line;Human Genetics;Human Genome;human model;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;insight;Intellectual functioning disability;Knowledge;Laboratories;Life;Light;Mediating;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neurogenetics;Neuronal Plasticity;Neurons;Neurosciences;Neurosciences Research;new therapeutic target;next generation sequencing;novel therapeutics;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathway interactions;Patients;Pediatric Neurology;Phenotype;Physicians;Physiological;Play;Positioning Attribute;Process;Program Development;programs;recruit;Regulation;Regulator Genes;Regulatory Element;Regulon;Research;response;Role;Scientist;single-cell RNA sequencing;Site;Source;Stimulus;synaptic pruning;Techniques;Technology;Testing;Therapeutic;Time;Training;transcription factor;translational neuroscience;Variant;Visual Cortex;Work

PROJECT_TITLE: The Role of Fos and the BAF Complex in Neuronal Activity-Dependent Chromatin Remodeling and Gene Expression

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: NARRATIVE HIV-infected, antiretroviral-treated women are more likely to have adverse birth outcomes, and their infants have altered immunity even in the absence of HIV-infection. Here, we will investigate the impact of maternal vaginal microbiome and metabolites during pregnancy and immune regulation and inflammation in placentas at delivery on preterm birth risk in HIV-infected women. We will utilize a long-standing cohort study population in Cape Town South Africa to determine which immune events at the fetal-maternal interface contribute to spontaneous preterm birth in HIV infection, and whether these relate to impaired newborn immunity.

PI_NAMEs: GRAY, CLIVE MAURICE (contact);JASPAN, HEATHER BERYL

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 16S ribosomal RNA sequencing;adverse birth outcomes;adverse pregnancy outcome;Africa South of the Sahara;African Women;Anti-Retroviral Agents;Area;Birth;Birth Weight;case control;Cells;Cellular Immunity;Cellular Stress;Child Health;cohort;Cohort Studies;Collaborations;Data;Decidua;Development;doctoral student;Epidemic;Event;experience;female reproductive tract;Fetal Development;Flow Cytometry;Funding;Gene Expression;Gene Expression Profile;Gestational Age;HIV;HIV Infections;HIV-exposed uninfected infant;Image;Immune;Immunity;Immunologics;immunoregulation;Impairment;in utero;Infant;Infant Health;Inflammation;Inflammatory;Investigation;Kenya;Life;Link;Location;Low Birth Weight Infant;Lung;Mass Spectrum Analysis;Maternal-Fetal Exchange;Measurement;Measures;Metabolic;Metabolic Marker;Metabolic Pathway;metabolome;microbial;microbial community;Microbiology;Morbidity - disease rate;Mothers;Neonatal Mortality;neonate;Neurologic;Newborn Infant;Outcome;Pathway interactions;perinatal HIV;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Placenta;Population;Postdoctoral Fellow;Postpartum Period;Pregnancy;Pregnant Women;premature;Premature Birth;Premature Infant;Premature Labor;Prevention Measures;prospective;Proxy;Regulatory T-Lymphocyte;Risk;Risk Factors;rRNA Genes;Sampling;Small for Gestational Age Infant;South Africa;South African;study population;T cell response;T-Lymphocyte;Tissues;Training;transcriptome sequencing;transmission process;ultrasound;Underrepresented Populations;United States National Institutes of Health;Universities;vaccine immunogenicity;Vaccines;Vagina;vaginal microbiome;vaginal microbiota;Villous;Woman;women's treatment;Work

PROJECT_TITLE: MECHANISMS LEADING TO ADVERSE BIRTH OUTCOMES IN SOUTH AFRICAN HIV-INFECTED WOMEN


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: PROJECT NARRATIVE Cancer is the second leading cause of mortality worldwide, with an estimated 9.6 million cancer- related deaths worldwide in 2018 (source – the World Health Organization). One of the major hurdles in treatment of cancer is the cancer cell’s ability to survive under adverse conditions and acquisition of drug resistance. Our proposal aims to study the mechanism(s) by which cancer cells successfully adapt to stress and maintain viability. The successful completion of our studies may provide new targets for therapeutic intervention in cancer treatment.

PI_NAMEs: BHANDARI, DEEPALI  (contact)

PROJECT_TERMS: acquired drug resistance;Antineoplastic Agents;Apoptosis;Biochemical;Biological Assay;Biological Process;cancer cell;Cancer Prognosis;cancer therapy;Cell Death;Cell Death Induction;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Stress;Centrifugation;Cessation of life;Chemoresistance;Chronic;Clinical Trials;coping;Cytoprotection;Data;Degradation Pathway;design;Diabetes Mellitus;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Endowment;Exhibits;experience;fascinate;Functional disorder;Germ Cells;glucose metabolism;Goals;Homeostasis;Hypoxia;Immunofluorescence Microscopy;improved;In Situ;insight;Knowledge;Life;Ligation;Location;Luciferases;Malignant Neoplasms;Mammalian Cell;Mediating;mimetics;misfolded protein;Molecular;Molecular Chaperones;molecular targeted therapies;mortality;mutant;Nerve Degeneration;new therapeutic target;novel;Outcome;Pathologic;Pathway interactions;Phase;Phosphorylation;Physiological;Play;Post-Translational Protein Processing;Production;programs;protein folding;protein protein interaction;Proteins;Proteomics;Publishing;recruit;Regulation;Reporter;Research;response;Role;Secretory Cell;sensor;Signal Pathway;Signal Transduction;Site;small molecule;Source;Stress;Techniques;Testing;Therapeutic Intervention;Time;timeline;Translations;Vesicle;virtual;Western Blotting;Work;World Health Organization

PROJECT_TITLE: Molecular Mechanisms Underlying Cell Survival During Endoplasmic Reticulum Stress


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Many identified psychotic disorder risk-related genomic variants are eQTLs located in noncoding DNA. It is likely that noncoding risk eQTLs associated with synaptic genes represent disrupted genomic enhancers that are typically active during synaptic organization. This proposal will test enhancer activity across development of synaptic gene eQTLs associated with psychotic risk and test allelic and cell-type differences of enhancers in the high-priority psychiatric risk gene CACNA1C.

PI_NAMEs: WARREN, TRACY LEIGH (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Alleles;Basic Science;Biological Assay;Biology;Bipolar Disorder;Brain;Brain imaging;Brain region;Calcium Channel;cell type;Code;Collection;Complex;Dependovirus;Development;Developmental Process;Diagnostic;Disease;disorder risk;DNA;Enhancers;Etiology;excitatory neuron;experimental study;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;genetic variant;genome wide association study;genomic variation;Genomics;Goals;Image;improved;in vitro Model;in vivo;Individual;inhibitory neuron;Injections;Introns;Label;Libraries;Link;Literature;Mental disorders;Meta-Analysis;Modeling;Molecular Target;Mus;Mutation;Nature;Neurons;Physiological;Plasmids;postnatal;postsynaptic neurons;primary outcome;Process;Production;protein aminoacid sequence;Protocols documentation;psychiatric genomics;psychotic;Psychotic Disorders;Quantitative Trait Loci;Regulatory Pathway;Reporter;Reporter Genes;Research;Risk;risk variant;RNA;Role;Schizophrenia;schizophrenia risk;Specificity;Synapses;synaptogenesis;Testing;therapeutic development;Time;Transcriptional Activation;Transcriptional Regulation;Untranslated RNA;Variant;Vertebral column;Viral Packaging;Virus;voltage;Work

PROJECT_TITLE: Identifying enhancers in schizophrenia and bipolar disorder-associated noncoding eQTLs during cortical synaptic organization


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE In this proposal, we will uncover the potential role of mTORC1 signaling for the treatment of type 1 diabetes. These studies will provide important findings that will have an impact to patients with type 1 diabetes by discovering novel targets that can be used to the development of novel therapies to treat this disease.

PI_NAMEs: BERNAL-MIZRACHI, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Allogenic;Antigens;Apoptosis;Autoimmune;Autoimmune Diseases;autoreactive T cell;B Cell Proliferation;B-Lymphocytes;Beta Cell;Biological Process;CD8-Positive T-Lymphocytes;Cell Death;Cell division;Cell Physiology;cell regeneration;Cell Size;Cell Survival;Complement;Complex;cytokine;cytotoxic;Data;design;Development;diabetes control;Diabetes Mellitus;Diabetes prevention;Disease;drug development;effector T cell;EIF4EBP1 gene;Environment;FRAP1 gene;Gender;Glucose;Growth;Growth Factor;human disease;IGFBP2 gene;Immune response;Immune system;Immune Targeting;immunoregulation;In Vitro;Incidence;Infiltration;Inflammatory;inflammatory milieu;Injury;insight;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;IRS2 gene;islet;Knowledge;Lipids;Lymphocyte;Lymphocyte Activation;lymphocyte proliferation;Lymphoid;male;Mediating;Messenger RNA;Metabolism;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Population;preservation;prevent;Prevention;Proliferating;Proteins;Publishing;Regulation;Regulatory T-Lymphocyte;response;Role;SCID Mice;Self Tolerance;sensor;sexual dimorphism;Signal Transduction;Skin Transplantation;Splenocyte;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;Translation Initiation;Translations;Up-Regulation

PROJECT_TITLE: Role of mTORC1 signaling in type 1 diabetes


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Hispanic young adults, including college students, have been the targets of tobacco marketing and this trend continues with the marketing of ENDS products on social media. Yet, we know little about the role of ENDS- related social media on the use of ENDS products by Mexican American college students, the largest subgroup of Hispanics. The proposed project will fill a void by examining the associations between ENDS- related social media exposure and engagement, and ENDS use among Mexican American college students, as well as the factors that explain and those that modify these associations.

PI_NAMEs: LOUKAS, ALEXANDRA ;WILKINSON, ANNA VICTORIA (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Acculturation;Adult;Age;age group;Area;Attitude;Behavior;behavior influence;Belief;Cigarette;Collection;college;Country;Data;Development;Ecological momentary assessment;electronic cigarette use;Electronic Nicotine Delivery Systems;English Language;Enrollment;Ethnic Population;Event;evidence base;expectation;experience;Exposure to;Female;First Generation College Students;follow-up;Goals;graduate school;Growth;health communication;High Prevalence;high risk;high school;Hispanic;hispanic community;Hispanic Populations;innovation;Intervention;Interview;Language;Link;Marketing;media use;Mediating;Mediation;Mediator;Methods;Mexican Americans;minority communities;Minority Groups;Morbidity - disease rate;mortality;novel;Outcome;peer;preference;prevent;Process;protective effect;Publications;Qualifying;Recording of previous events;Research;Risk;Role;Sampling;social cognitive theory;social media;social norm;South Texas;Student recruitment;Students;Subgroup;substance use;Surveys;Testing;Texas;theories;TikTok;Tobacco;tobacco advertising;Tobacco Industry;Tobacco use;trend;university student;young adult

PROJECT_TITLE: Social Media, Acculturation and E-cigarette Use among Mexican American College Students in South Texas


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal will define how interferon-gamma, a major T-cell cytokine abundant in atherosclerotic plaques, alters fuel utilization by the vascular cells that line the innermost layer of the coronary arteries, thereby making these vessels susceptible to atherosclerosis progression. This study, if successful, will improve our understanding of the adverse changes involving vascular metabolism in atherosclerosis and may lead to new therapeutic strategies to prevent heart attacks, strokes, and limb loss.

PI_NAMEs: LEE, LAUREL Y (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;Adhesions;Advisory Committees;Affect;angiogenesis;Anti-Inflammatory Agents;Antiatherogenic;Aorta;Apolipoprotein E;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biochemistry;Biological Assay;Biological Availability;Biology;Blood Vessels;Carbon;Cardiology;Cardiovascular system;Carnitine Palmitoyltransferase I;Catabolism;Cell Adhesion Molecules;Cell Communication;Cell Line;cell type;Cellular Metabolic Process;Circulation;Citric Acid Cycle;Clinical;Coronary Arteriosclerosis;Coronary artery;cytokine;Data;Development;Diet;Disease;disorder prevention;Doctor of Medicine;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;Enzymes;Equilibrium;extracellular;fatty acid oxidation;Fellowship;Free Radical Scavengers;Functional disorder;Funding;Genetic Transcription;Glucose;glucose metabolism;Glycolysis;Glycolysis Inhibition;Goals;Guanosine;Homeostasis;Hospitals;Human;Immune;immune activation;Immunofluorescence Immunologic;Immunological Models;Immunologics;Immunology;immunoregulation;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Inflammation Mediators;Inflammatory Response;inhibitor;instructor;Interferon Type II;Kinetics;Label;Lead;Leukocytes;limb loss;Link;Lipid Peroxidation;Lipids;Lipoxins;liquid chromatography mass spectrometry;Mediating;medical schools;Medicine;Mentors;Metabolic;metabolic profile;Metabolism;metabolomics;migration;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;novel;novel therapeutic intervention;overexpression;Oxidation-Reduction;Oxidative Stress;Pathologic;Pathology;Periodicity;pharmacologic;Phenotype;Physicians;Physiological;Predisposition;prevent;Principal Investigator;Production;Proliferating;Prostaglandins I;Radioisotopes;Reactive Oxygen Species;Research;Research Personnel;Risk Factors;Role;Scientist;shear stress;Signaling Molecule;single cell technology;single-cell RNA sequencing;skills;Source;stable isotope;Stroke;Surface;Systems Biology;T-Cell Activation;T-Lymphocyte;Testing;thrombotic;Time;Training;Training Programs;transcriptomics;Trimetazidine;Tube;Up-Regulation;Vasodilation;Woman;Work

PROJECT_TITLE: Endothelial Metabolic Reprogramming by Interferon-gamma in Coronary Artery Disease

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: The immune system is adept at clearing bacterial infection, however, certain bacteria can pose a difficult challenge that stimulates the immune response to form a structure called a granuloma. This structure is seen in important infections such as tuberculosis, however, granuloma functions have been difficult to study due to a lack of model systems. We have discovered a new granuloma model that allows us to study basic granuloma biology in laboratory mice.

PI_NAMEs: MIAO, EDWARD A (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Abscess;adaptive immune response;Antigen-Antibody Complex;Bacteria;Bacterial Infections;bactericide;Biological Models;Biology;C57BL/6 Mouse;CASP1 gene;CASP4 gene;Caspase;Cd68;Cell Death;cell type;Cells;Chromobacterium;Chromosome Mapping;Collagen;Complex;Deposition;Disease;DNA;Fibroblasts;Foreign Bodies;Goals;Grant;Granuloma;Granulomatous;Hepatocyte;Homeostasis;Immune;Immune response;Immune system;Immunologic Stimulation;Infection;Infectious Agent;innovation;Invaded;Kupffer Cells;Laboratory mice;Lesion;Liver;Macrophage;microbial;Modeling;Molecular;mouse model;Mus;Necrosis;neutrophil;NOS2A gene;novel;Organ;pathogen;Pathology;prevent;Process;recruit;response;Stains;Stimulus;Structure;Susceptibility Gene;T-Lymphocyte;Thick;Tissues;trait;Tuberculosis;Virulence

PROJECT_TITLE: Pyroptosis maintains the integrity of a granuloma


NIH_SPENDING_CATS: Aging;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative: In older adults, emergency department (ED) return visits resulting in a hospital admission (RVA) have dramatically higher morbidity and mortality than patients admitted on their initial ED visit. We propose to develop an automated ED screening tool to identify older adults at risk of RVA within 72 hours following an initial ED visit, using machine learning to accurately predict this multifactorial event. Findings from this research will improve the ability of ED clinicians to identify this vulnerable population for subsequent risk-mitigating interventions.

PI_NAMEs: STEEL, PETER ARTHUR DEBLIEUX (contact);ZHANG, YIYE

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Adult;adverse outcome;arm;Assessment tool;Caring;Categories;Classification;Clinical;clinical care;Clinical Data;clinical decision support;clinical practice;Cognitive;Communicable Diseases;comorbidity;comparative;Complex;Critical Care;Data;Decision Making;design;Diagnosis;Disease;Disease Progression;Elderly;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency department screening;Emergency department visit;Emergency Medicine;Emergency Situation;Ensure;Environment;Ethnic Origin;Etiology;Event;experience;Feasibility Studies;Geography;Geriatric Assessment;Goals;Guidelines;health data;health record;Health system;high risk;Hospital Mortality;Hospitalization;Hospitals;Hour;implementation design;implementation study;improved;improved outcome;Informatics;innovation;interdisciplinary collaboration;Intervention;Interview;Judgment;Leadership;Link;Machine Learning;machine learning model;machine learning prediction;Managed Care;Manuals;Medicare claim;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;older adult;Operative Surgical Procedures;Outcome;Output;Patient Admission;Patient Noncompliance;patient subsets;Patient-Focused Outcomes;Patients;Performance;Physicians;Population;Practice Guidelines;predict clinical outcome;predictive modeling;Process;prospective;prototype;randomized, clinical trials;Recommendation;Research;Risk;Risk Assessment;Risk Factors;risk mitigation;risk prediction model;screening;Screening procedure;Severities;Site;social health determinants;socioeconomics;Structure;Subgroup;support tools;Surveys;Technology;Testing;theories;Time;tool;Translating;usability;Validation;Variant;Visit;Vulnerable Populations;Work

PROJECT_TITLE: GEMRA: Geriatric Emergency Medicine Risk Prediction Model for Return VisitAdmissions