NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Prevention

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The present crisis caused by SARS-CoV-2 (COVID-19) has harshly illuminated the ability of coronavirus pandemics to sicken and kill millions of individuals, ruin large parts of the economy, and to lead to great social stress. Vaccines, oral and systemic medications, and monoclonal antibodies have all proven effective against SARS-CoV-2, but each has encountered problems with uptake and/or viral and societal resistance, and there is presently no drug on the market with pan-coronavirus activity that would anticipate SARS-CoV-2 evolution and outbreaks of new and deadly coronavirus infections. We have used targeted molecular engineering of a lectin (sugar-binding protein) to create a new broad-spectrum, well-tolerated antiviral agent with significant activity against all coronaviruses tested, including SARS-CoV-2 and variants such as Omicron, and here propose studies that will lead to the effective clinical implementation of intranasal use of this new agent to prevent and treat infection with SARS-CoV-2, diverse coronaviruses, and also ultimately influenza.

PI_NAMEs: MARKOVITZ, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Ambulatory Care Facilities;animal coronavirus;Animal Model;Animals;Anti-viral Agents;Atomic Force Microscopy;Banana;Binding;Binding Proteins;Cells;chimeric antibody;Chiroptera;Clinical;clinical implementation;Communities;Coronavirus;Coronavirus Infections;coronavirus pandemic;coronavirus treatment;COVID-19 vaccine;delivery vehicle;Development;Directed Molecular Evolution;Dose;Ebola;Effectiveness;efficacy evaluation;Engineering;Epidemic;Evolution;Formulation;Future;future epidemic;glycosylation;Good Manufacturing Process;Half-Life;Hamsters;Hepatitis C;Hepatitis C virus;HIV;Home;Human;hybrid antibody;Immune;immune activation;Immune system;Immune Tolerance;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;improved;In Vitro;in vivo;Individual;Infection;Infection prevention;Influenza;Influenza A virus;Influenza B Virus;influenza virus strain;Intranasal Administration;large scale production;Lectin;Legal patent;Life;Light;Mannose;Mannose Binding Lectin;Manufactured Materials;Marketing;Measles;Mediating;Membrane Proteins;Middle East Respiratory Syndrome Coronavirus;Mink;Modality;Modeling;Molecular;molecular modeling;Molecular Target;Monoclonal Antibodies;mouse model;Mus;Mutate;nanoparticle;New Agents;new outbreak;Nose;novel coronavirus;Oral;Outpatients;pandemic potential;Parents;pathogen;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;Phenotype;Polysaccharides;prevent;prophylactic;Prophylactic treatment;Proteins;Rattus;Resistance;Route;Safety;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 variant;Severe Acute Respiratory Syndrome;Site;social;social stress;stem;sugar;Surface;Testing;Textiles;therapeutic evaluation;therapeutically effective;uptake;Vaccines;Viral;viral epidemic;viral pandemic;Viral Physiology;Virus

PROJECT_TITLE: Molecularly Engineered Lectins for Intranasal Prophylaxis and Treatment of Coronaviruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: HEALTH RELEVANCE This project investigates how the brain preserves and selects information about multiple sensory stimuli. Deficits in this ability contribute to poor communication performance in noisy scenes in central auditory processing disorder and age-related hearing loss. Insights from these experiments could ultimately lead to improvements in the treatment of these and related conditions.

PI_NAMEs: GROH, JENNIFER M (contact);TOKDAR, SURYA T

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Afferent Neurons;analysis pipeline;Area;Attention;Attention Deficit Disorder;Auditory;auditory pathway;auditory processing;autism spectrum disorder;Behavioral;behavioral response;Brain;Central Auditory Processing Disorder;Code;Cognition;Communication;Complex;Data;Data Set;Disease;Electrodes;Exhibits;experimental study;Eye Movements;Health;improved;Individual;Inferior Colliculus;insight;Joints;Measures;member;Mind;Modeling;Motor;Motor Skills;multimodality;neural;Neurons;novel;organizational structure;Pattern;Perception;Performance;Population;Presbycusis;preservation;Property;Research;response;Saccades;sample fixation;Sensory;sensory stimulus;Series;Short-Term Memory;Stimulus;Stream;Structure;superior colliculus Corpora quadrigemina;Taxes;Testing;Time;tool;Visual;Visual Pathways

PROJECT_TITLE: Information Preservation in Neural Codes


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PI_NAMEs: ODWYER, PETER J (contact)

PROJECT_TERMS: Acceleration;Adult;American College of Radiology Imaging Network;anti-cancer research;biobank;Biological;Biological Markers;Biometry;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;care outcomes;Center for Translational Science Activities;Clinical Markers;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;Community Practice;Complex;Conduct Clinical Trials;Dana-Farber Cancer Institute;Data;Data Analyses;Data Coordinating Center;Databases;Development;Disease;Eastern Cooperative Oncology Group;Environment;Funding;Generations;Goals;Image;imaging study;Immunologics;improved;improved outcome;Infrastructure;innovation;Investigational Therapies;Laboratories;Lead;Malignant Neoplasms;Mentorship;Modeling;next generation;novel;operation;Participant;Patients;Population;Positioning Attribute;Prevalence;Procedures;programs;Protocols documentation;quantitative imaging;Reporting;Research;Research Personnel;Resources;Science;scientific organization;Site;Specialized Program of Research Excellence;Structure;System;Translating;treatment effect;Universities

PROJECT_TITLE: Clinical Trials Development Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Diabetes;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chronic skin wounds in patients with type II diabetes do not heal, as they are stalled at an inflammation phase without any growth of blood vessels that would typically close the gap. Exosomes, which are nanosized vesicles secreted by multipotent stromal cells and can be isolated from cell culture, show great promise in promoting faster closure in chronic wounds. In our study, we will investigate how exosomes and their cargo precisely affect major cell types in the wound, to resolve the stalled inflammation and let wound healing proceed.

PI_NAMEs: RABBANI, PIUL SANJANA (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acceleration;Acute;Address;Affect;angiogenesis;Animal Model;Anti-Inflammatory Agents;arginase;Biochemical Process;Biological Assay;Blood Vessels;Bone Marrow;career;career development;Cell Culture Techniques;cell motility;Cell Physiology;Cell Separation;cell type;Cells;Chronic;Chronic Disease;chronic wound;Clinical;Coculture Techniques;Communication;Communities;cost;Data;Dermal;design;diabetic;Diabetic mouse;diabetic ulcer;diabetic wound healing;Disease;Dissociation;Dose;educational atmosphere;effective therapy;Endothelial Cells;Epitopes;Event;evidence base;Excision;exosome;Genes;Goals;Granulation Tissue;Growth;healing;Human;IL6 gene;Immune;immunoreactivity;Impaired healing;Impaired wound healing;In Vitro;Inflammation;Inflammatory;inhibitor;intercellular communication;Knowledge;Literature;Macrophage;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;Mediator;Medical;Mentorship;Microvascular Dysfunction;Modeling;Molecular;monocyte;Mus;nanosized;nanovesicle;neovascularization;Non-Insulin-Dependent Diabetes Mellitus;overexpression;p38 Mitogen Activated Protein Kinase;Pathologic;Pathway interactions;Patients;Phase;Phenotype;Physiological;Plasminogen Activator Inhibitor 1;Play;pre-clinical;preclinical study;Proliferating;Proteins;Proteomics;Publishing;rational design;re-epithelialization;Research;Research Design;Resolution;response;RNA;Role;Safety;Signal Pathway;skin wound;social;Source;spatiotemporal;STAT3 gene;Stromal Cells;Testing;Therapeutic Effect;therapy design;Time;Tissues;tool;Training;Transcript;transcriptomics;Translational Research;Type 2 diabetic;uptake;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vesicle;Wild Type Mouse;wound;wound bed;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Exosome treatment-induced mechanisms in chronic wound beds - Resubmission - 1


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Digital health platforms (DHP) use computing technologies, connectivity, software, and sensors for health care. DHP have the potential to increase health equity for minority groups, the proposed innovative study evaluates a DHP model that leverages on a patient portal to engage race/ethnic groups, who has been disproportionally affected by COVID-19, digitally deliver an intervention (i.e., mindfulness) targeted to mitigate COVID related stress, and remotely collect self-reported psychological and physiological metrics of mental health and autonomic regulation. These findings have implications on precision medicine by providing access and remote/real-time report on the person’s health to offer a targeted intervention, while focus on increasing access to care for race/ethnic populations.

PI_NAMEs: DAVILA, MARIA I;GAYLORD, SUSAN  (contact);HEILMAN, KERI J

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accountability;Address;Affect;Anxiety;Anxiety Disorders;anxiety symptoms;arm;Arousal;authority;barrier to care;Behavioral;Biofeedback;Biological;Black Populations;clinically significant;Communities;Computer software;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 stress;current pandemic;Data;digital;digital delivery;digital health;Effectiveness;Electronic Health Record;emotional distress;Engineering;Environment;Equilibrium;ethnic minority;ethnic minority population;Ethnic Population;Evidence based intervention;experience;Face;follow-up;Frequencies;Goals;group intervention;Health;health disparity;health equity;health equity promotion;health record;Health Services;Health Services Accessibility;Health Technology;Healthcare;Healthcare Systems;Heart Rate;heart rate monitor;heart rate variability;Human;Improve Access;improved;inclusion criteria;indexing;innovation;insight;instructor;Integrative Medicine;International;internet delivery;Intervention;Latino Population;Link;Measures;Medical;Mental Health;Mental health promotion;mindfulness;Mindfulness Training;mindfulness-based stress reduction;Minority;Minority Groups;Mobile Health Application;Modeling;multidisciplinary;Nonpharmacologic Therapy;Outcome;Participant;patient engagement;patient oriented;patient portal;Patient Self-Report;perceived stress;Personal Satisfaction;personalized medicine;Persons;physical conditioning;Physiological;Population;post intervention;precision medicine;Prediction of Response to Therapy;Prognosis;programs;Psychiatry;psychologic;Psychophysiology;Public Health;Quality of life;Race;Racial Equity;racial minority;racial minority population;racial population;Randomized;Randomized, Controlled Trials;recruit;Regulation;Reporting;Research;resilience;Resources;satisfaction;Scientist;screening;Self Administration;sensor;service member;social;Stress;stress management;stressor;Symptoms;Tablets;targeted delivery;Technology;Testing;Time;Training;treatment effect;Treatment Efficacy;underserved minority;Vision;Waiting Lists;wearable device;wearable sensor technology

PROJECT_TITLE: Digital health platform (DHP) to deliver Mindfulness as a Stress Management Intervention Leveraging Electronic (SMILE) health records for racial and ethnic populations during the COVID-19 pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(56)R]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Precision Medicine;Rare Diseases

PROJECT_TERMS: Address;Adult;American College of Radiology Imaging Network;anti-cancer research;Area;biobank;Biological;Biological Markers;Biometry;Cancer Biology;cancer care;Cancer Center;cancer clinical trial;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;care outcomes;Categories;Center for Translational Science Activities;Clinical Markers;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;Community Practice;Complex;Credentialing;Dana-Farber Cancer Institute;Data;Data Analyses;Data Coordinating Center;Databases;Developmental Therapeutics Program;Disease;Eastern Cooperative Oncology Group;Environment;Evaluation;Fostering;Funding;Genomics;Goals;Image;imaging study;Immunologics;improved;improved outcome;Infrastructure;innovation;Institution;Investigational Therapies;Laboratories;Lead;Malignant Neoplasms;member;Mentorship;Modeling;Monitor;next generation;novel;operation;Participant;Patients;peer;Population;Positioning Attribute;Prevalence;Process;programs;quantitative imaging;rare cancer;Research;Research Personnel;Science;scientific organization;Site;Special Population;Specialized Program of Research Excellence;Structure;System;Tissues;Translating;treatment effect;Universities

PROJECT_TITLE: Member Site Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Lupus;Microbiome;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Autoimmune diseases afflict up to 12% of the US and lupus, as one autoimmune disease, remains a leading cause of medical death in young women of child-bearing age. This program is testing a number of potential drivers and protectors of autoimmune disease using unique patient cohorts and broad investigator expertise.

PI_NAMEs: JAMES, JUDITH A (contact);RATHMELL, JEFFREY C.

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adaptive immune response;Address;age related;Apoptosis;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;Avidity;B-Cell Activation;B-Lymphocytes;Benign;Bioinformatics;Biological Markers;biomarker identification;Cell Count;Cells;Cellular Immunology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Characteristics;Chronic;Classification;Clinical;Clinical Data;clinical investigation;clinical predictive model;cohort;Collaborations;Collection;cytokine;Data;data integration;Development;Disease;Disease Progression;dysbiosis;Early Diagnosis;Epigenetic Process;Epitope spreading;Exhibits;extracellular;Female of child bearing age;Flare;Frequencies;Functional disorder;Future;Genes;Genetic;Genetic Transcription;Genomics;high risk population;imaging approach;Immune;Immune Targeting;Immunology;Impairment;improved;Individual;Inflammatory;Innate Immune Response;Interferon Type I;Knowledge;Link;longitudinal design;Lupus;Lymphopenia;Measures;Mediating;Mediator;Medical;member;Metabolic;Metabolism;metabolomics;microbial;microbiome;microbiota;Minority Groups;Mitochondria;mitochondrial metabolism;Molecular;monocyte;Morbidity - disease rate;mortality;multiple omics;Myeloid Cells;Natural History;novel therapeutics;Nucleic Acids;Onset of illness;Organ;Participant;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;Population;pre-clinical;predictive modeling;prevent;Prevention;Prevention trial;Process;Production;Productivity;programs;Proliferating;Publishing;Questionnaires;Regulation;Research;Research Personnel;response;restraint;Risk;Risk Assessment;Risk Factors;Risk Reduction;RNA;Role;sample collection;Sampling;Science;Scientist;Sentinel;Signal Transduction;single cell ATAC-seq;Source;Specificity;System;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Time;Tissues;TLR7 gene;transcriptome sequencing;Treatment-related toxicity;Validation;Viral;virome;young woman

PROJECT_TITLE: Autoimmune Drivers and Protectors Team Science (ADAPTS)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The Western States Node renewal application to participate in the Clinical Trials Network has broad public health implications, developing and testing strategies to close gaps in the addiction treatment cascade. The research agenda seeks to repurpose medications and uses electronic health records to collect data in hybrid effectiveness-implementation trials.

PI_NAMEs: HUMPHREYS, KEITH N.;KORTHUIS, PHILIP TODD (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Academic Medical Centers;addiction;Address;advanced analytics;Ambulatory Care Facilities;American;Behavioral;behavioral health;Buprenorphine;California;care coordination;care providers;care systems;Caring;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinics and Hospitals;Cluster randomized trial;Collaborations;complex data;Conduct Clinical Trials;Data;Data Science;Data Set;data warehouse;Drug abuse;drug repurposing;Drug usage;Drug Use Disorder;Drug user;effective therapy;effectiveness/implementation trial;Electronic Health Record;experience;Future;General Practitioners;Goals;Health;Health Services;Health system;Healthcare;Hospitals;Hybrids;Hydromorphone;implementation trial;improved;Infrastructure;innovation;Intervention;Leadership;Life;Managed Care;Medicaid;Medical;medical specialties;medication for opioid use disorder;Methadone;Methamphetamine;methamphetamine use;Methamphetamine use disorder;mHealth;Mirtazapine;Morbidity - disease rate;mortality;multi-site trial;National Institute of Drug Abuse;Neighborhood Health Center;novel;Opiate Addiction;opioid use disorder;Oral;Oregon;Patients;peer;peer support;Persons;Pharmaceutical Preparations;Pharmacotherapy;phase III trial;Placebos;Policies;Policy Maker;Population;Positioning Attribute;pragmatic trial;Primary Care;primary care patient;protocol development;Protocols documentation;Provider;Public Health;Publications;Randomized;Recording of previous events;Recovery;Research;Research Personnel;Research Support;Resources;Rural Community;San Francisco;Science;Services;Site;substance use;Substance Use Disorder;success;Supervision;sustained recovery;Techniques;telehealth;Telephone;Testing;Training;Translating;treatment center;trial comparing;Trillium;Universities;University Hospitals;Veterans;Vulnerable Populations

PROJECT_TITLE: Western States Node of the National Drug Abuse Treatment Clinical Trials Network


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE  The goal of this research program is to overcome the multiple scattering limit in optical coherence tomography, and thereby address one of the grand challenges in the field of optical microscopy. We will synergistically combine the advantages of a long-wavelength spectral-domain OCT system with adaptive optics, and the principle behind the highly promising coherent accumulation of single scattering method. We propose to demonstrate the deepest OCT imaging to date, in both human skin and mouse brain tissues, which is significant from the perspective of both fundamental imaging science as well as the biomedical applications of OCT.

PI_NAMEs: ADIE, STEVEN GRAHAM (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;adaptive optics;Address;Algorithms;Attention;Ballistics;Big Data;Biological;Brain;brain tissue;clinical application;Creativeness;data acquisition;Data Set;deep field survey;Development;Ensure;Event;experimental study;Feedback;Fiber;Floor;Freedom;fundamental research;Geometry;Goals;Human;Image;imaging capabilities;imaging science;Imaging technology;in vivo;Knowledge;Length;Light;Lighting;Measurement;meter;Methods;Microscopic;Microscopy;Modality;Motivation;multiphoton microscopy;Mus;Noise;novel strategies;Optical Coherence Tomography;optical imaging;Optics;parallel processing;Performance;Phase;Photons;processing speed;programs;Publishing;Research;Resolution;Sampling;Scheme;Shapes;Signal Transduction;Skin;Skin Tissue;Speed;Spottings;success;System;Techniques;Thick;Time;Tissues;titanium dioxide

PROJECT_TITLE: Overcoming the Multiple Scattering Limit in Optical Coherence Tomography

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goal of this project is to develop statistical methodologies for the analysis of complex multimodal biomedical imaging data that display non-linear geometric structure. The proposed models will allow biomedical scientists to fully exploit contemporary datasets to validate their scientific hypotheses and to discover imaging biomarkers that leverage both structural and functional features of an organ.

PI_NAMEs: LILA, EARDI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Adopted;Adoption;Alzheimer's Disease;anatomic imaging;Anatomy;Behavioral;biobank;Biological;Biological Process;biomedical imaging;biomedical scientist;Classification;Communities;Complex;computational anatomy;Computer software;computerized tools;connectome;Coupled;Data;Data Analyses;data analysis pipeline;Data Display;Data Pooling;Data Reporting;Data Set;Development;Diagnosis;diagnostic algorithm;Disease;Disease Progression;Ecosystem;Electroencephalography;Functional Imaging;Functional Magnetic Resonance Imaging;Genetic;genetic information;geometric structure;Goals;high resolution imaging;Human;Image;imaging biomarker;imaging software;improved;interest;interoperability;Joints;Knowledge;Libraries;Maps;Measurement;Medical;Methodology;Methods;Modeling;Modernization;multimodality;Names;neuroimaging;non-traditional data;novel;open source;open source tool;Organ;Paper;Parkinson Disease;predictive modeling;predictive tools;progression marker;Property;Research Personnel;Scientist;Shapes;Signal Transduction;software development;Software Tools;Statistical Data Interpretation;Statistical Methods;Statistical Models;structural imaging;Structure;Surface;Thick;Time;tool;user friendly software;Variant;web page;X-Ray Computed Tomography

PROJECT_TITLE: Statistical models for the integrative analysis of complex biomedical images with manifold structure

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This application will investigate HAVCR2 (TIM3), recently identified genetic risk factor for late-onset Alzheimer’s disease, as a target to modulate microglial function and regulate development of Alzheimer’s disease (AD). We identified TIM3 as a key inhibitory molecule in microglia that inhibits their function resulting in progression of AD. Therefore targeting Tim3 in microglia can restore microglial functions and promote clearance of Ab plaques in animal models of AD. The outcomes of the project will have considerable impact on both advancing the basic science of AD and novel TIM3-based immuno-modulating approach for the treatment of AD.

PI_NAMEs: BUTOVSKY, OLEG ;KUCHROO, VIJAY K. (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;aging brain;Agonist;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein Precursor;Animal Model;Antibodies;Antigen Presentation;Antigens;Area;Autoimmune Diseases;Basic Science;Behavior;Binding;Blocking Antibodies;Brain;cancer clinical trial;cancer therapy;Cell Physiology;Chronic;Cognitive;cytokine;Data;Dementia;Dendritic Cells;Deposition;Development;Disease;Disease associated microglia;Disease Progression;drug candidate;exhaustion;Genetic;genetic linkage;genetic risk factor;genome wide association study;glial activation;Goals;Human;human induced pluripotent stem cells;Immunity;immunoregulation;improved;induced pluripotent stem cell;Investigation;Laboratories;Late Onset Alzheimer Disease;Ligands;Link;Maintenance;Malignant Neoplasms;Microglia;Modeling;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;novel;novel therapeutic intervention;Onset of illness;Outcome;Pathology;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Phosphorylation;Play;Receptor Signaling;Regulation;response;restraint;risk variant;Role;Signal Induction;Signal Transduction;synergism;T-Lymphocyte;Tauopathies;TGFB1 gene;therapy development;Transcript;Translating;Tumor Immunity;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: SHREVEPORT

ORG_DEPT: NEUROLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Cardiac arrest is the most devastating disease in the United States affecting more than 550,000 people per year. Despite prompt emergency treatment and better resuscitation techniques, 70-90% of patients die from extensive brain injury, with only three to ten percent of patients able to resume their former lifestyles. Our goal is to understand the mechanisms of serum/glucocorticoid regulated kinases that cause brain injury after cardiac arrest, to lay the foundation for novel therapeutic interventions against cardiac arrest.

PI_NAMEs: LEE, REGGIE HUI-CHAO (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Affect;astrogliosis;Behavioral trial;Bioenergetics;Biological;Blood capillaries;Brain;Brain Injuries;Cardiopulmonary Arrest;Cause of Death;Cell Survival;cell type;Cerebral Ischemia;Cerebrovascular Circulation;Cessation of life;chromatin immunoprecipitation;Circulation;Clinical Trials;Complex;cresyl violet;cytokine;Data;disability;Disease;Emergency treatment;Enzyme-Linked Immunosorbent Assay;Enzymes;Eukaryotic Cell;Family;Flow Cytometry;fluoro jade;Foundations;Genes;genetic approach;Genus Hippocampus;Goals;Heart;Heart Arrest;Hippocampus;Histology;Homeostasis;Human;hypoperfusion;Immunoassay;Immunohistochemistry;Induced Neurons;Inflammation;Inflammatory;inhibitor;Injury;Ions;Ischemia;Ischemic Brain Injury;Kidney;Laser Scanning Microscopy;Laser Speckle Imaging;Learning;Life Style;Link;Liver;Measures;Mediating;Mediator;member;Memory;Memory impairment;Messenger RNA;Microcirculation;Microglia;Mitochondria;mitochondrial dysfunction;Monitor;mouse model;neoplastic;Nerve Degeneration;neuroinflammation;Neurologic Deficit;neuron loss;neuronal survival;Neurons;neuropeptide Y;Norepinephrine;novel;novel therapeutic intervention;object recognition;Organ;overexpression;Pathology;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphotransferases;Physiological;Pilot Projects;Play;Predisposition;Prognosis;Protein Microchips;Protein-Serine-Threonine Kinases;Proteins;Rattus;Regulation;Regulatory Element;Reporting;Resuscitation;Rodent Model;Role;Secondary to;Sgk protein;small hairpin RNA;Spirometry;Stains;Survival Rate;Sympathetic Nervous System;Techniques;Testing;Therapeutic;therapeutic target;Translating;two photon microscopy;two-photon;United States;Up-Regulation;Vasoconstrictor Agents

PROJECT_TITLE: Kinase regulation in cerebral ischemia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Some subpopulations of genetically identical bacteria are killed more slowly than others: this is termed antibiotic tolerance and this tolerance may contribute to the long treatment time for tuberculosis (six months) as well as the development of drug-resistance. However, there are many different forms of antibiotic tolerance with distinct molecular mechanisms and it is not known which forms are most prevalent in, and contribute most to antibiotic susceptibility in animal infection and development of drug-resistance. We will compare two different types of tolerance in clinical strains of Mycobacterium tuberculosis – the cause of tuberculosis -- and determine the genetic mechanisms by which they mediate antibiotic susceptibility and development of drug-resistance.

PI_NAMEs: JAVID, BABAK  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Animal Model;Animals;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antitubercular Agents;Antitubercular Antibiotics;Bacteria;bactericide;Biological Assay;Cells;Clinical;clinically relevant;deep sequencing;Development;DNA-Directed RNA Polymerase;Drug resistance;drug resistance development;Drug resistance in tuberculosis;Drug Tolerance;Evolution;Exhibits;Fluorescence;forward genetics;Genes;Genetic;genetic resistance;Genus Mycobacterium;In Vitro;in vivo;Infection;Insertional Mutagenesis;Maps;Measures;Mediating;Methods;Molecular;mouse model;Mouse Strains;Mus;Mutagenesis;Mutation;Mycobacterium tuberculosis;Necrosis;novel;Organism;Outcome;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Phylogenetic Analysis;Physiological;Population;Population Sizes;Predisposition;Prevalence;Regimen;Resistance;Resistance development;Rifampicin resistance;Rifampin;small molecule;Testing;Time;trait;Treatment outcome;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Variant;Vertebral column

PROJECT_TITLE: Antibiotic tolerance as a stepping stone to tuberculosis drug-resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CORAL GABLES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE  Surgeon scientists play key roles in discoveries and translation of research advances into improved health care for patients. To address a critical shortage in the next generation of otolaryngology surgeon scientists, a new training program that integrates basic, translational, epidemiologic, and clinical sciences into the clinical training of otolaryngology residents and medical students is proposed. This mentored research training program aims to address barriers that prevent trainees from achieving successful academic surgeon scientist careers that facilitate scientific discoveries and advances in hearing and communication disorders that align with the NIDCD mission.

PI_NAMEs: LIU, XUE Z (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Achievement;Address;Award;Basic Science;career;career development;Clinical;Clinical Research;Clinical Sciences;clinical training;Communication impairment;Creativeness;Dedications;design;Discipline;Disease;Educational Curriculum;Enrollment;Epidemiology;epidemiology study;Ethics;Evaluation;experience;Faculty;faculty mentor;Failure;Fostering;Foundations;Funding;Future;Goals;Grant;Head and Neck Surgery;Health;Healthcare;Hearing problem;improved;Infrastructure;Institution;interdisciplinary approach;Interdisciplinary Study;interest;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Mind;Minority;Mission;Motivation;National Institute on Deafness and Other Communication Disorders;next generation;Operative Surgical Procedures;Otolaryngologist;Otolaryngology;outreach;Pathway interactions;Patient Care;Patients;Physicians;Play;Positioning Attribute;pre-doctoral;prevent;Process;Productivity;programs;Public Health;public health relevance;Qualifying;recruit;Reporting;Research;Research Personnel;Research Support;Research Training;Residencies;Resources;role model;Scientific Advances and Accomplishments;Scientist;skills;Study Section;success;Surgeon;Training;Training Programs;Translational Research;Translations;trend;United States National Institutes of Health;Universities

PROJECT_TITLE: Miami Otolaryngology Surgeon-Scientist  Training  Program  (MOSSTP)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative (Public Health Relevance) An improved understanding of how the human lens establishes and maintains transparency over many decades of life is urgently required if therapies to delay the onset and/or progression of cataract in our increasingly aging population are to be developed. By identifying specific molecular changes to lens water channels, aquaporins, that occur with age and their functional consequences, specific therapeutic strategies can be pursued. Such anti-cataract therapies are expected to significantly decrease the incidence of cataract in our aging population, improving not only quality of life but also reducing the enormous financial costs associated with the current surgical treatments for cataract.

PI_NAMEs: SCHEY, KEVIN L (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adhesives;Age;age related;age related changes;Aging;aging population;Agreement;Anterior;Biological Assay;Blindness;capsule;Cataract;Cell Adhesion;Cell membrane;cell preparation;Circulation;Crystallins;Data;Development;diabetic cataract;differential expression;Epithelium;Exposure to;extracellular;fiber cell;Financial cost;Financial Hardship;Future;Gap Junctions;Generations;Goals;Healthcare Systems;Homeostasis;Human;imaging modality;improved;Incidence;Integral Membrane Protein;Ions;Knock-out;lens;Lens development;Lens Fiber;lens transparency;Life;Lipids;Liquid substance;Maintenance;Mass Spectrum Analysis;Measures;Mechanics;Mediating;Membrane;Membrane Proteins;Methods;Microcirculation;Microscopy;MIP gene;Modification;Molecular;Morphology;Multimodal Imaging;novel therapeutics;Nuclear;Nutrient;operation;Operative Surgical Procedures;Organ Culture Techniques;Osmosis;Oxidative Stress;Pathway interactions;Peripheral;Permeability;Play;Post-Translational Protein Processing;Property;Proteomics;public health relevance;Publishing;Quality of life;regional difference;Reporting;Research;response;Role;Side;solute;Stimulus;Stress;Structure;Surface;Surgical sutures;System;Testing;Therapeutic;Time;Tissues;trafficking;Travel;Vascular blood supply;Vesicle;Water;water channel;water diffusion;water flow;Water Movements;Work

PROJECT_TITLE: The Role of Aquaporins in Lens Structure and Function

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Although kidney cancers are typically infiltrated with large numbers of the patient's immune cells, these tumors often escape an effective immune response, and many are resistant to immunotherapy. We will test the idea that an effective T cell response to the cancer is inhibited by macrophages (a type of immune cell), driven by a protein called IRF8, and, using novel mouse models of the disease, we will test whether suppressing macrophages can reduce tumor growth and improve responses to therapy. This work may reveal strategies to improve the effectiveness of immunotherapy and combination therapies for patients with kidney cancers.

PI_NAMEs: HAKIMI, ABRAHAM ARI (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;advanced disease;Affect;anti-PD-1;anti-PD-L1;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Atlases;Breast Cancer Model;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Physiology;Cells;Clear cell renal cell carcinoma;Clinic;clinical development;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;Cross Presentation;Data;Disease;disease model;Effectiveness;effector T cell;Endothelial Growth Factors Receptor;exhaustion;Exhibits;experience;Flow Cytometry;Gene Expression Profile;Genetic;Growth Factor Inhibition;high risk;Human;IFN consensus sequence binding protein;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunocompetent;Immunologic Surveillance;Immunologic Tests;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;Infiltration;inhibitor;inhibitor therapy;Localized Disease;Macrophage;Malignant Neoplasms;Maps;Mediating;Minority;Modeling;mosaic;mouse model;multidrug resistance inhibition therapy;Mus;novel;patient response;patient subsets;Patient-Focused Outcomes;Patients;PDL1 inhibitors;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;predictive modeling;Process;prognostic significance;Proteins;Renal Carcinoma;Renal Cell Carcinoma;Repression;Research;Resistance;Resources;response;Role;single-cell RNA sequencing;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;Translating;treatment response;treatment strategy;tumor;Tumor Antigens;tumor growth;tumor immunology;Tumor-associated macrophages;Tumor-infiltrating immune cells;Vascular Endothelial Growth Factors;Virulence;Work

PROJECT_TITLE: Macrophages as modulators of T cell function and therapeutic response in clear cell renal cell carcinoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Lung;Lung Cancer;Patient Safety;Precision Medicine;Radiation Oncology

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Surgery and stereotactic body radiation therapy are the only recommended treatments for stage I lung cancer, a highly prevalent and curable disease. Since the lack of evidence-based treatment allocation in stage I lung cancer remains a critical unmet need, we will perform a prospective, pragmatic, multi-center cohort study to compare the effectiveness of surgery and SBRT for stage I lung cancer. Additionally, we will develop and compare prediction models for treatment outcomes for an individual patient with stage I disease and create a benchmark for personalized treatment allocation in lung cancer.

PI_NAMEs: KOZOWER, BENJAMIN D (contact);PURI, VARUN ;ROBINSON, CLIFFORD GRANT

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Adverse event;Aftercare;Benchmarking;Cancer Etiology;Cancer Patient;Caring;Characteristics;Clinical;cohort;Cohort Studies;comorbidity;comparative effectiveness;comparative effectiveness study;Comparative Study;compare effectiveness;Data;Databases;design;Disease;Disease-Free Survival;Disparate;Early Diagnosis;Equipoise;Evidence based treatment;experience;Goals;improved;individual patient;Information Systems;Institution;Investigation;Knowledge;Light;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;medical specialties;Modeling;Morbidity - disease rate;mortality;National Comprehensive Cancer Network;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;patient advocacy group;Patient Care;Patient Outcomes Assessments;Patient-Centered Care;Patients;personalized medicine;Population Study;pragmatic study;predictive modeling;preference;premature;prospective;Provider;Publications;Publishing;Radiation Oncology;Radiation therapy;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research Design;Retrospective Studies;Sample Size;Scanning;Selection Bias;Societies;Surgical Oncology;systematic review;Techniques;Thoracic Surgical Procedures;Treatment outcome;trial comparing;tumor;web-based tool;Work;X-Ray Computed Tomography

PROJECT_TITLE: Comparative Effectiveness of Surgery vs Stereotactic Radiation Therapy for Stage I Lung Cancer

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Acute respiratory distress syndrome is an unrelenting inflammation of the lungs that occurs after various insults such as influenza infection. This proposal will evaluate mechanisms that drive the persistent inflammation after injury, and the knowledge gained can be applied to the development of new therapeutic options for patients with lung inflammation.

PI_NAMEs: CHEN, PETER  (contact);PARKS, WILLIAM C

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Respiratory Distress Syndrome;airway epithelium;alveolar epithelium;Apoptosis;Apoptotic;Attenuated;Biological Assay;Biology;Cell Death;Cell surface;Cells;Cessation of life;Data;Development;Disease;Eating;Epithelial Cells;Epithelium;Etiology;Failure;Feedback;Goals;Immune response;Immunity;immunoregulation;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;Injury;insight;Intervention;Knowledge;Learning;Link;Lung;lung injury;lung repair;Macrophage;Mediating;Modeling;Morbidity - disease rate;Mus;Necrosis;neutrophil;novel;novel therapeutics;Outcome Study;Pathologic;Pathway interactions;Patients;Phagocytes;Phagocytosis;Phenotype;prevent;Process;programs;Proteoglycan;Pulmonary Inflammation;recruit;repaired;Reporting;Research;Resolution;response;Risk Factors;Role;Signal Transduction;syndecan;Testing;Tissues;Virus Diseases;Wild Type Mouse;wound healing

PROJECT_TITLE: Syndecan-1 suppression of lung inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE O-linked ß-N-acetylglucosamine (O-GlcNAc) is a sugar attachment on proteins. Breast cancer tissues show significantly elevated O-GlcNAc-ylation compared to corresponding adjacent normal tissue. The outcomes from our proposed investigations will enable us to (i) identify how O- GlcNAc-driven reprogramming in breast cancer cells aberrantly activates Hedgehog signaling; (ii) create mechanistic understanding of how O-GlcNAc-ylation programs tumor cell invasion and response to anti-neoplastic drugs, and (iii) discover how elevated systemic O-GlcNAc-ylation programs tumor-intrinsic and tumor-extrinsic (immune microclimate) features of breast tumors.

PI_NAMEs: SHEVDE, LALITA A. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: ABCB1 gene;Antineoplastic Agents;Attenuated;Biological Models;Biological Process;Breast Cancer Cell;Breast Cancer Model;cancer cell;cancer type;Carbohydrates;Cell Cycle Progression;Cell Proliferation;Cells;Characteristics;Chemicals;Chemoresistance;chemotherapeutic agent;cytotoxic;Diabetes Mellitus;Diet;DNA Repair;DNA Repair Gene;Embryonic Development;Erinaceidae;Event;Genetic;Genetic Transcription;GLI gene;Glucose;glucose uptake;Homeostasis;Human;Hydroxyl Radical;Hyperglycemia;Immune;Impairment;Investigation;Licensing;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolism;Microclimate;Modeling;Modification;Molecular;mouse model;neoplastic cell;Neurodegenerative Disorders;Normal tissue morphology;novel;Nutritional status;Outcome;Pathway interactions;patient derived xenograft model;Phenotype;Process;programs;Proteins;Proteomics;Reporting;Research Design;resilience;response;Role;Serine;Side;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;smoothened signaling pathway;Structure;success;sugar;Testing;Threonine;Tissues;tool;transcription factor;triple-negative invasive breast carcinoma;tumor;Tumor Cell Invasion;tumor progression;Up-Regulation

PROJECT_TITLE: Role of O-GlcNAc-ylation on tumor progression

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Prevention;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE National guidelines do not support routine mammography screening in older women (ages 75 and older) and recommend consideration of life expectancy and patient preferences; yet many providers still refer and many patients still receive frequent mammography screening. This research seeks to advance our understanding of the most effective and feasible methods and patient, provider, and organizational solutions for reducing mammography overscreening across a large healthcare system serving a racially/ethnically diverse population of older women in New York City, with the ultimate goal of reducing the use of low-value care.

PI_NAMEs: MOISE, NATHALIE ;SHELTON, RACHEL C;TEHRANIFAR, PARISA  (contact)

PROGRAM_OFFICER_NAME: BRICK, RACHELLE SOPHIA

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adoption;Advocate;Age;aged;American College of Physicians;Anxiety;Area;Breast Cancer Detection;Breast Cancer Risk Factor;care delivery;Caring;Clinic;Cluster randomized trial;Communities;Complex;crowdsourcing;Data;Data Collection;Deimplementation;design;Development;Diagnosis;Diagnostic tests;Effectiveness;Equilibrium;ethnic diversity;Evidence based practice;Excision;experimental study;Family member;follow-up;Frequencies;Future;Goals;Guidelines;Habits;Health;health care delivery;Healthcare Systems;Hybrids;implementation framework;implementation science;implementation strategy;improved;innovation;Knowledge;Learning;Letters;Life Expectancy;Malignant Breast Neoplasm;Mammary Neoplasms;Mammographic screening;Mammography;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;New York City;older adult;older patient;Older Population;older women;Outcome;overtreatment;Patient Preferences;Patients;Population Heterogeneity;preference;Process;Provider;racial diversity;Recommendation;recruit;Reporting;Research;Research Design;Research Personnel;Risk;Science;Screening for cancer;screening guidelines;System;Testing;theories;tumor;United States National Institutes of Health;United States Preventative Services Task Force;Woman;Work

PROJECT_TITLE: De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: (K.220) 8. Project Narrative Opioid use disorder (OUD) is associated with disproportionate deficits in recovery capital (i.e. recovery resources) and while OUD medications (MOUDs) aid recovery, these recovery capital deficits often persist, increasing biobehavioral stress and relapse risk. Recovery Community Centers (RCCs) are a free, newly emerging tier of recovery support services that serve as ‘one-stop-shops’ for recovery capital, celebrate all pathways to recovery (including MOUD), and appear to be particularly beneficial for MOUD patients, but few patients or clinicians know of RCCs, clinical linkage to them is uncommon, and their potential benefit to MOUD patients has yet to be systematically investigated. To advance understanding of the clinical and public health utility of RCCs and help bridge the gap between clinical treatment and community-based recovery support services, this study will be the first to develop and test an intervention for peer-facilitated assertive linkage of MOUD patients to RCCs using a randomized design, with the potential to change clinical practice paradigms and address ongoing psychosocial deficits in MOUD patients by helping them obtain the needed resources to achieve and sustain OUD remission.

PI_NAMEs: HOFFMAN, LAUREN A (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adherence;Adopted;Aftercare;Ambulatory Care;Aphorisms;Assertiveness;Award;biobehavior;Buprenorphine;buprenorphine treatment;Capital;Chronic;Clinic;Clinical;clinical practice;Clinical Treatment;clinically relevant;Communities;Coping Skills;Data;design;Development;Disease remission;Ensure;Evaluation;Exhibits;experience;Feasibility Studies;Feedback;follow-up;Foundations;Future;Goals;Guidelines;health determinants;Impairment;improved;Individual;insight;Intervention;Intervention Studies;Interview;Link;Maintenance;Manuals;Measures;meetings;member;Mentors;Methods;National Institute of Drug Abuse;novel;opioid epidemic;opioid misuse;opioid use disorder;optimism;Outcome;Overdose;Pathway interactions;patient retention;Patients;peer;peer support;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacotherapy;Procedures;programs;protective effect;Protocols documentation;provider intervention;psychosocial;Public Health;Publishing;Qualitative Methods;Randomized;randomized trial;Randomized, Controlled Trials;Recovery;recovery community organization;recovery house;recovery services;Recovery Support;recruit;relapse risk;Research;Resources;retention rate;Risk;safety net;satisfaction;secondary outcome;Services;Stress;Substance Use Disorder;sustained recovery;Telephone;Testing;therapy development;Training;treatment program;Visit;volunteer;Work

PROJECT_TITLE: Developing and testing an intervention to enhance recovery capital amid opioid use disorder pharmacotherapy: A pilot randomized trial of assertive linkage to recovery community centers

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The proposed research will establish a novel RNA bioengineering platform technology, and define the mechanistic actions of particular human noncoding microRNAs in the control of xenobiotic & nutrient metabolism and disposition as well as their applications to improving drug efficacy. Results from this project are anticipated to open up new ways to produce biologic RNA molecules for basic research and drug development.

PI_NAMEs: YU, AIMING  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Amino Acid Transporter;Amino Acids;Anabolism;Animal Disease Models;Basic Science;Bioenergetics;Biological;Biological Assay;biomaterial compatibility;Biomedical Engineering;Biotechnology;Cell Survival;Cells;Cellular Metabolic Process;Chemicals;clinically relevant;cofactor;Collection;Coupled;Data;design;Development;Disease;drug action;drug development;drug disposition;drug efficacy;Drug Exposure;Drug Modulation;Effectiveness;Endotoxins;Engineering;Enzymes;Family;Fermentation;Fluorouracil;Gene Expression;Genome;Glucose;Glucose Transporter;Glycolysis;Homeostasis;Human;Human Cell Line;improved;In Vitro;in vivo;in vivo Model;innovation;inorganic phosphate;insight;inter-individual variation;invention;Knowledge;Laboratories;large scale production;Liposomes;macromolecule;Malignant Epithelial Cell;Mediating;Metabolic;Metabolism;metabolome;MicroRNAs;Modeling;Modification;nanocomplexes;new therapeutic target;novel;novel therapeutic intervention;Nutrient;nutrient metabolism;Oncolytic;Oxidases;peptide chemical synthesis;Pharmaceutical Preparations;Pharmacodynamics;polypeptide;Post-Transcriptional Regulation;posttranscriptional;pre-miRNA;Primary carcinoma of the liver cells;Production;Proliferating;protein expression;Proteins;Pyridoxal Phosphate;Recombinants;Regulation;Research;research and development;response;RNA;Role;Safety;Seminal;SLC2A1 gene;solute;success;sugar;synergism;Techniques;Technology;technology platform;Testing;Therapeutic;therapy outcome;tool;Transfer RNA;tumor xenograft;tumorigenesis;Untranslated RNA;uptake;Vitamin B6;Vitamin B6 Metabolism Pathway;Vitamins;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Recombinant microRNAs in xenobiotic and nutrient disposition

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Immunotherapy;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Bladder cancer remains a highly lethal disease despite recent success of immune checkpoint therapy due to resistance to immune checkpoint inhibitors in the majority of bladder cancer cases. We identified that tumor- associated Schwann cells promote an immunosuppressive microenvironment in bladder cancer and determined that the expression of long noncoding RNAs in tumor-associated Schwann cells regulates the enzymatic activities of TDO2 and thus facilitates the expansion of immunosuppressive MDSC cells. Hence, targeting tumor- associated Schwann cells expressing noncoding RNAs should advance our understanding of bladder cancer immunoresistance and pave the way for developing combinatorial therapies for bladder cancer patients to overcome resistance to immunotherapy.

PI_NAMEs: GAO, JIANJUN ;YANG, LIUQING  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: antagonist;anti-PD-1;anti-PD-L1 antibodies;Antibodies;Antisense Oligonucleotides;Astrocytes;Attenuated;bioinformatics tool;Biology;Bladder;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Catalysis;Cells;checkpoint therapy;Clinical;clinical effect;Collaborations;combinatorial;Communities;Data;design;Disease;Dissociation;Effectiveness;effector T cell;Equilibrium;fluorocitrate;Future;Goals;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;immune resistance;immunodeficiency;Immunologic Cytotoxicity;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infiltration;inhibitor;innovation;Interdisciplinary Study;Interleukin-6;Kinetics;Knockout Mice;Kynurenine;kynurenine aminotransferase II;Kynurenine-oxoglutarate aminotransferase;locked nucleic acid;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Metabolic;Modeling;Molecular;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;novel;novel strategies;Oncogenic;Pathway interactions;Patients;PD-1/PD-L1;PD-L1 blockade;Pharmaceutical Preparations;Phosphorylation;plasmacytoma variant translocation gene 1;Platinum;Play;Production;prognostic value;RAF1 gene;Reagent;Research;Resistance;response;Role;Schwann Cells;Signal Transduction;small molecule;small molecule inhibitor;success;targeted treatment;Therapeutic;therapeutic RNA;therapeutic target;Tissues;Toxic effect;Tryptophan;Tryptophanase;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Molecular Mechanisms of Bladder Cancer Immunometabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Psychosis;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Hallucinations are common in older adults with neurodegenerative diseases such as Parkinson disease or Alzheimer disease and carry a poor prognosis. The goal of this project is to determine whether visual impairment and age-related eye disease are associated with the development and severity of hallucinations in older adults. This information will be used to develop clinical screening and treatment guidelines for high-risk patients with the goal of preventing hallucinations and improving quality of life.

PI_NAMEs: HAMEDANI, ALI G (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adverse effects;Affect;Age;age related;Age related macular degeneration;Aging;Alzheimer's Disease;Alzheimer's disease patient;atypical antipsychotic;Biometry;Black Box;Blindness;Brain;Brain Diseases;Caregivers;Caring;Cataract;Cataract Extraction;Cessation of life;Chronic;Clinical;clinical investigation;clinical practice;Cognitive;Cognitive aging;cohort;comorbidity;constriction;Data;Data Analyses;Data Collection;Data Correlations;data management;Development;Diagnosis;Disease;Disparity;Distress;Dose;Epidemiologist;Epidemiology;epidemiology study;evidence base;experience;Eye;Eye diseases;fall risk;Funding;Future;ganglion cell;glaucoma surgery;Goals;Hallucinations;Health;Health and Retirement Study;Health Services Research;Health Surveys;Healthcare;high dimensionality;high risk;Hip Fractures;Image;Impaired cognition;improved;Incidence;Individual;Injury;Inner Plexiform Layer;Intervention;K-Series Research Career Programs;Knowledge;Link;longitudinal analysis;macula;Masks;Measurement;Measures;Medicare;Medicare claim;Mentors;Mentorship;Modeling;mortality;Nerve Degeneration;Neurocognitive;Neurodegenerative Disorders;Neurology;neuropsychiatry;Nursing Homes;older adult;Ophthalmologist;Ophthalmology;Optical Coherence Tomography;Outcome;Outcome Measure;Outcomes Research;Parkinson Disease;Pathogenesis;Patients;Pennsylvania;Peripheral;Persons;Pharmaceutical Preparations;Play;Population;Positioning Attribute;premature;prevent;Prevention;Preventive;Primary Open Angle Glaucoma;Prognosis;programs;Progressive Disease;prospective;Prospective cohort;Prospective Studies;Public Health;Quality of life;recruit;Reproducibility;Request for Proposals;Research;Research Personnel;Research Training;response;Retinal Ganglion Cells;retinal imaging;Risk;Risk Factors;Role;Sampling;screening guidelines;Severities;Source;stroke risk;Structural Models;Structure;Survival Analysis;Testing;Thick;Time;Training;treatment guidelines;Treatment outcome;treatment response;trend;Universities;Vision;Visual;Visual Acuity;Visual Cortex;Visual Fields;Visual Hallucination;Visual impairment;Visual Pathways;Visual System

PROJECT_TITLE: Vision and hallucinations in older adults


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PUBLIC RELEVANCE More than a third of adults in the United States are obese, as a result of overeating and sedentary lifestyle and obesity increases the risk for diabetes, heart disease, stroke, cancer, and other health problems. The goal of this project is to study the role of a novel energy-sensing enzyme, Inositol Polyphosphate Multikinase (IPMK), in muscle function and whole body metabolism under normal and overnutrition conditions. We anticipate that our research in mouse and cellular models will reveal how disruption of IPMK pathways in muscle potentially predisposes to obesity, diabetes and abnormal lipid metabolism.

PI_NAMEs: AHIMA, REXFORD S. (contact);KIM, SANGWON F

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acetylation;Acute;Address;Adult;Animal Model;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;blood glucose regulation;Body Weight decreased;Cell Differentiation process;Cell model;Cell Physiology;Cell Proliferation;Cells;chemical genetics;Chronic;Collaborations;comparison control;Data;Deacetylase;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes risk;Diet;diet-induced obesity;Disease;Energy Metabolism;Enzymes;epigenomics;Exercise;Exercise Physiology;Exercise Tolerance;experimental study;Fatty acid glycerol esters;Fatty Acids;feeding;FRAP1 gene;Genetic;genetic corepressor;Genetic Transcription;Glucose;Goals;HDAC3 gene;Health;Heart Diseases;High Fat Diet;Histones;Homeostasis;Hyperphagia;impaired glucose tolerance;Impairment;in vivo;Inositol;Inositol Phosphates;inositol polyphosphate multikinase;Insulin;insulin sensitivity;Knowledge;Laboratories;lipid metabolism;Lipids;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Molecular;mouse model;Mus;Muscle;Muscle Cells;Muscle function;novel;novel therapeutic intervention;novel therapeutics;Null Lymphocytes;Nutrient;nutrient metabolism;Obesity;Overnutrition;oxidation;Pathway interactions;Physical activity;Physiology;Play;Polyphosphates;Proteins;Regulation;Regulatory Pathway;Reporting;Research;respiratory;response;Rest;Role;sedentary lifestyle;Signal Pathway;Signal Transduction;Signaling Molecule;Skeletal Muscle;small molecule;Stroke;Time;Tissues;tool;Transcriptional Regulation;transcriptomics;treadmill;United States;Weight Gain

PROJECT_TITLE: Role of skeletal muscle IPMK in nutrient metabolism and exercise

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Diversity in the biomedical research workforce improves research quality, promotes strong learning environments, fosters scientific innovation, and increases the likelihood that health disparities are addressed. Discovery PREP promotes the success of underrepresented trainees working to become biomedical scientists by fostering development of the technical and professional skills which promote excellence in scientific research and graduate school.

PI_NAMEs: ASKWITH, CANDICE C (contact);GLASPER, ERICA R;MCDOUGLE, LEON

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic skills;Accountability;Achievement;Address;Admission activity;Advisory Committees;Affect;Attitude;Award;Bachelor's Degree;Biomedical Research;biomedical scientist;career;Career Mobility;cohort;college;Communities;Complex;Critical Thinking;design;Development;Development Plans;Doctor of Philosophy;education research;educational atmosphere;Educational workshop;Ensure;Ethics;Evaluation;experience;Faculty;formative assessment;Fostering;Funding;Future;Goals;Graduate Degree;graduate school;health disparity;Healthcare;improved;Individual;innovation;Institution;Interview;Knowledge;Laboratories;Leadership;Literature;Medicine;meetings;member;Mentors;Ohio;Outcome;Outcomes Research;Participant;peer coaching;Performance;Postbaccalaureate;posters;Preparation;Productivity;Program Effectiveness;programs;Recommendation;Reporting;Reproducibility;Research;role model;Scholars Program;Science;Secure;Self Efficacy;Series;Services;skill acquisition;skills;Societies;STEM field;Structure;success;Talents;Technical Expertise;Testing;Training;Travel;undergraduate student;Underrepresented Populations;Universities;Vocational Guidance;Wages;Work

PROJECT_TITLE: Ohio State University Discovery PREP for Biomedical Research

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PHR: PROJECT NARRATIVE Our research infrastructure supports the development and implementation of innovative clinical trials to answer a broad spectrum of translational substance abuse treatment research questions across a wide variety of treatment settings and diverse patient populations. Dissemination partners facilitate training in evidence-based treatments to reach non-treatment seeking drug using patients and improve their treatment outcomes.

PI_NAMEs: FEASTER, DANIEL J;METSCH, LISA R;SZAPOCZNIK, JOSE  (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Accident and Emergency department;Address;Adolescent;Adoption;Adult;Affect;Area;Awareness;behavioral health;bioinformatics tool;Caring;Child health care;Clinic;Clinical;Clinical Research;Clinical Treatment;clinical trial implementation;Clinical Trials;Clinical Trials Network;Cocaine;Collaborations;Communities;community partners;comorbidity;Data;data registry;Data Science;design;Development;Disparity;Dissemination and Implementation;Drug abuse;Drug usage;economic disparity;Education;Effectiveness;eHealth;Electronic Health Record;Epidemic;evidence base;Evidence based treatment;experience;Family;Florida;Foundations;Harm Reduction;Health;health care settings;health economics;Health Personnel;Health system;Healthcare;Healthcare Systems;Hispanic Populations;HIV;HIV/HCV;Hospitals;Human immunodeficiency virus test;implementation science;improved;individual response;Infrastructure;innovation;Intervention;Lead;Leadership;Learning;Life Expectancy;Mainstreaming;Medical;medical specialties;medication for opioid use disorder;Mental disorders;Mental Health;Methamphetamine;Methods;Modeling;National Institute of Drug Abuse;novel strategies;Opioid;opioid epidemic;opioid use disorder;Outcome Study;Overdose;overdose death;patient population;Patients;Pharmaceutical Preparations;point of care;Population;Practice based research;precision medicine;Precision therapeutics;prevent;Prevention;prevention service;Primary Care;primary care setting;Provider;Puerto Rico;recovery services;Registries;Research;Research Infrastructure;Risk;Schools;Science;Scientist;screening;service delivery;Services;Sexually Transmitted Diseases;Site;social disparities;social stigma;Social support;stimulant use;substance abuse treatment;substance use;Substance Use Disorder;success;Surgeon;synergism;Technology;Testing;Time;Training;translational pipeline;Treatment outcome;treatment program;treatment research;treatment response;treatment services;Universities;Work

PROJECT_TITLE: The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Kaposi's sarcoma-associated herpesvirus (KSHV) is an emerging Group 1 pathogen and the major cause of cancers in untreated AIDS patients. KSHV, like other DNA viruses, expresses a class of genes late during infection that are essential for viral assembly and escape from their host cell, but how the expression of these genes is regulated has long remained unknown. This grant is focused on revealing how a group of KSHV proteins orchestrates this process though a combination of molecular mimicry and co-option of host gene expression machinery.

PI_NAMEs: GLAUNSINGER, BRITT A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Architecture;Area;Binding;Binding Proteins;Biological Assay;Biology;C-terminal;C-terminal binding protein;cancer diagnosis;Cancer Etiology;Cells;Central Africa;Complex;Congenital Disorders;Cytomegalovirus;Data;Disease;Distal;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA replication origin;DNA Viruses;Double Stranded DNA Virus;Enhancers;Eukaryota;experimental study;gammaherpesvirus;Gene Activation;Gene Expression;Genes;Genetic Transcription;Genome;Grant;Herpesviridae;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hybrids;Immunocompromised Host;Individual;Infection;insight;Late Gene Transcriptions;Late Promoters;Life;Life Cycle Stages;Link;Lytic;Malignant Neoplasms;Measures;member;mimicry;Modeling;Molecular Mimicry;mouse model;Mutation;mutation screening;N-terminal;novel;Oncogenic;pathogen;Patients;Polymerase;Population;Process;Production;promoter;protein complex;Proteins;recruit;Regulation;Replication Origin;RNA Polymerase II;Role;structural biology;TATA Box;TATA-Box Binding Protein;Testing;Transcription Coactivator;transcription factor;Transcription Initiation;Transcriptional Regulation;Viral;viral DNA;Viral Genome;Viral Proteins;Virion;Virus;Virus Assembly;Virus Replication

PROJECT_TITLE: Regulation of Gammaherpesviral Late Gene Expression

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Diabetes;Endocrine Disruptors;Genetics;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The proposed application will use the mouse model to investigate how exposure to perfluorooctanoic acid (PFOA) adversely influences maternal glucose homeostasis during pregnancy. Human studies suggest that PFOA exposure is associated with increased risk for gestational diabetes, however these observations have not been validated experimentally and the underlying mechanisms are not well understood. In this work, we will define how exposure to PFOA disrupts serotonin metabolism in maternal pancreatic islets and how genetic differences in vitamin B6 metabolism modulate the susceptibility to PFOA-induced gestational diabetes in pregnant mice.

PI_NAMEs: SUSIARJO, MARTHA  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Affect;Agonist;Agreement;Alkaline Phosphatase;Antibodies;Beta Cell;Binding;Biological Availability;Biology;blood glucose regulation;C57BL/6 Mouse;Cell Proliferation;Child;Chronic;cofactor;Complex;Country;Data;Diabetes Mellitus;Diagnosis;dietary;Dietary Factors;Disease;Dose;Endocrine Disruptors;environmental chemical;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;epigenome;epigenomics;Etiology;Event;Exposure to;Failure;fasting glucose;Fetal health;gene environment interaction;Gene Expression;Genetic;Gestational Diabetes;Glucose Intolerance;Goals;Health;health of the mother;histone modification;Human;Immunofluorescence Immunologic;Impairment;insight;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;Knowledge;Ligands;Link;Liquid Chromatography;Mass Spectrum Analysis;Maternal Health;maternal hyperglycemia;Metabolic;Metabolism;Methods;Mothers;mouse model;Mus;National Health and Nutrition Examination Survey;Non-Insulin-Dependent Diabetes Mellitus;obstetrical complication;Pancreas;Participant;perfluorooctanoic acid;Phenotype;phosphatase inhibitor;Physiological;Pilot Projects;Play;Predisposition;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;Premature Infant;prevent;Production;programs;Proliferating;Public Health;Publishing;Pyridoxal Phosphate;receptor;Receptor Activation;Regulation;Reporting;Research;Resolution;response;Risk;Risk Factors;Role;Second Pregnancy Trimester;Serotonin;serotonin receptor;Serum;Signal Transduction;Structure of beta Cell of islet;Testing;transcriptome;transcriptome sequencing;transcriptomics;Vitamin A;Vitamin B6;Vitamin B6 Metabolism Pathway;Woman;Work

PROJECT_TITLE: Gene-environment interaction in islet serotonin metabolism and impacts on maternal glucose homeostasis

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Brain Disorders;Data Science;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: RELEVANCE (See instructions): Scientific discovery today is being enabled through computation- and data-intensive research that exploits the enormous amounts of available data. A key barrier in using neurophysiological data for research is the crushing computation burden involved in processing large volumes of complex signal data. The overall goal of this project is to create AI-ready neurophysiological data resources to transform the access and sharing of such resources for accelerating brain health research.

PI_NAMEs: ZHANG, GUO-QIANG  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Architecture;Archives;Area;base;Blood;Blood Pressure;body position;Body System;Brain;brain electrical activity;brain health;Breathing;Chronic Care;Collection;Communities;Complex;Data;data access;Data Collection;Data Files;data format;data resource;data reuse;Data Science;Data Sources;Databases;design;Diagnosis;diagnosis standard;Diagnostic;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;European;Evaluation;Event;Eye Movements;FAIR principles;Frequencies;Funding;Future;Genomics;Goals;Gold;Health;Heart Rate;heart rhythm;Hour;Human;improved;indexing;Individual;Ingestion;innovation;Instruction;interactive visualization;Label;limb movement;Link;machine learning algorithm;Managed Care;Measures;medical specialties;member;Motivation;Nervous System Disorder;neurophysiology;Online Systems;Outcome;outreach;Oxygen;Pattern;Polysomnography;Positioning Attribute;Prevention;prognostic;prospective;Readiness;repository;Research;Research Design;Research Personnel;Resources;secondary analysis;Seizures;Semantics;Signal Transduction;Skeletal Muscle;Sleep;Sleep Disorders;Sleep Stages;Snoring;Source;Specific qualifier value;standard of care;sudden unexpected death in epilepsy;System;United States National Institutes of Health;usability;Visualization

PROJECT_TITLE: SCH: Neurophysiological AI-Ready Data Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is an autoimmune disease that affects over 3 million Americans, for which there is no cure, resulting in lifelong treatment with insulin. This project will address the gap in knowledge about the mechanisms responsible for T1D progression. Understanding these mechanisms is essential to development of new therapies to treat and prevent T1D.

PI_NAMEs: LONG, S ALICE  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Affect;American;Antigens;ATAC-seq;Autoantibodies;Autoimmune Diseases;Beta Cell;Biological Models;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Assay;Chronic;chronic infection;Clinical;cohort;constitutive expression;Cytometry;Data;Defect;Development;Dimensions;Disease;disease heterogeneity;Disease Progression;Epigenetic Process;exhaust;exhaustion;Exhibits;Favorable Clinical Outcome;Foundations;Frequencies;Funding;Genetic Transcription;Goals;Heterogeneity;Human;IL2 gene;Immune;Immunologic Factors;Immunology;improved;In Vitro;Inflammation;innovation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interleukin-12;Interleukin-15;Interleukin-2;islet;Knowledge;Lead;Ligation;Link;Longitudinal cohort;Malignant Neoplasms;Manuscripts;Metabolic;Molecular;novel therapeutics;Outcome;Pathway interactions;Patients;Phenotype;Pilot Projects;Play;Population;pre-clinical;prevent;Process;Production;Publishing;receptor;Receptor Activation;receptor expression;response;Role;Sampling;Science;Seminal;Signal Pathway;Signal Transduction;Source;System;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapy design/development;therapy development;transcription factor;transcriptome sequencing;treatment response;Viral;Virus Diseases;Work

PROJECT_TITLE: Defining mechanisms of CD8 T cell exhaustion in T1D

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ORG_CITY: IOWA CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Public Health Relevance Both maintaining tissue function and multiple diseases are associated with prostaglandin signaling and collective cell migration, but little is known about the relationship between these two processes. The work in this proposal will increase the understanding of how prostaglandin signaling promotes collective cell migration. This information will provide insight into the origins of numerous diseases ranging from birth defects and impaired wound healing to cancer metastasis.

PI_NAMEs: TOOTLE, TINA L (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Actins;Address;Aspirin;Behavior;Biochemical;biophysical techniques;Bundling;Cardiovascular Diseases;cell motility;Cell Nucleus;Cell Physiology;Cells;cohesion;Complex;Congenital Abnormality;Cytoskeleton;Disease;Drosophila genus;Enzymes;Equilibrium;Eukaryotic Cell;fascin;Fertility;Genetic;Ibuprofen;Impaired wound healing;in vivo;Individual;Inflammation;insight;Knowledge;Lipids;Malignant Neoplasms;mechanotransduction;Mediating;migration;Myosin ATPase;Neoplasm Metastasis;Non-Steroidal Anti-Inflammatory Agents;novel therapeutics;Nuclear;Oogenesis;prevent;Process;Prostaglandin-Endoperoxide Synthase;Prostaglandins;public health relevance;Role;Signal Pathway;Signal Transduction;Signaling Molecule;System;Time;Tissues;transmission process;Work;wound healing

PROJECT_TITLE: Prostaglandins and actin remodeling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Optimizing the mental health and cognitive abilities of people living with HIV-1 will require an understanding of the biological connections between these functions and HIV-1 infection in the central nervous system (CNS). We will examine, at a single cell or provirus level, the CNS disease profile of both viremic and antiretroviral therapy (ART)-suppressed participants over time. Discovery of the mechanism of how HIV-1 impacts the CNS will lead to innovative targeted therapies that could modulate immunological factors or block specific viral effects to improve neuropsychological outcomes even without total elimination of the CNS HIV-1 reservoir.

PI_NAMEs: CYKTOR, JOSHUA CHARLES;SPUDICH, SERENA S (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: AIDS clinical trial group;antiretroviral therapy;Attention;Autopsy;Behavior;Binding;Biological;Biological Assay;Blood;brain tissue;CD4 Positive T Lymphocytes;Cell Lineage;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Characteristics;Clinical;clinically significant;Clonality;Cognitive;cognitive ability;cognitive control;cognitive function;cognitive neuroscience;cohort;combinatorial;comorbidity;Complex;Coupled;cytokine;Data;Detection;Disease;Disease associated microglia;Disease remission;DNA;Emotions;executive function;Frequencies;Functional disorder;Gene Expression Profile;Genetic Transcription;Genetic Variation;genome sequencing;Goals;HIV;HIV Infections;HIV Seronegativity;HIV-1;Immune;Immunologic Factors;Immunologics;immunoregulation;improved;Infection;Inflammatory;inflammatory milieu;innovation;insight;integration site;Length;Link;Living Donors;lymph nodes;Measures;Mental Health;Methods;Microglia;Modeling;Molecular;Motor;Myeloid Cells;National Institute of Mental Health;Nature;neuropsychiatry;Neuropsychology;novel;Outcome;Participant;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Proviruses;Puncture procedure;reproductive tract;Research Domain Criteria;RNA;single cell analysis;single cell technology;Site;Sorting;Spinal Puncture;System;targeted treatment;Techniques;Time;Tissues;Transcript;transcriptomics;Viral;Virus

PROJECT_TITLE: CNS Viral Persistence and Neuropsychiatric Perturbations in HIV:  Single cell and Molecular Interrogation


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative The population of the United States is becoming increasingly diverse and research and healthcare issues are becoming increasingly diverse and complex as well. Despite this, the biomedical research workforce remains largely undiversified and there are urgent needs and demands for workforce and experiential diversity for creative problem solving, which will improve the health and lives of all. The UMB STAR-PREP program was designed to holistically, rigorously and comprehensively prepare diverse students to enter and be successful in strong MD-PhD and PhD programs and then in careers to address critical biomedical workforce diversity needs.

PI_NAMEs: ANTALIS, TONI M;CAREY, GREGORY B (contact)

PROJECT_TERMS: Academic Training;Acceleration;Address;Admission activity;African;American;Anxiety;Award;Back;Baltimore;Biomedical Research;Black race;career;cohort;Communities;Complex;Creativeness;design;Development;Development Plans;Dimensions;Diverse Workforce;Doctor of Philosophy;Dropout;education research;Educational workshop;Emotional;Enrollment;Ensure;Environment;Equilibrium;Evaluation;expectation;experience;Faculty;Faculty Workshop;Failure;Feeling;Fright;Funding;Goals;graduate school;Health;Healthcare;Hearing;Hispanic;Immersion;improved;innovation;Institution;Laboratories;Latino;Leadership;Learning;Life;Maryland;Mental Depression;Mentors;Modeling;National Institute of General Medical Sciences;Native Americans;outcome prediction;peer;Performance;Persons;Population;Postbaccalaureate;Preparation;Problem Solving;Process;Productivity;programs;Psyche structure;Readiness;recruit;Research;research and development;Research Training;Services;Shapes;social;student participation;Students;success;symposium;Syndrome;Technology;Testing;Trust;tutoring;United States;Universities;volunteer

PROJECT_TITLE: UMB Postbaccalaureate Research Education Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Pain Research;Regenerative Medicine;Rehabilitation

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The objective of this proposal is to engineer a load-bearing, allogeneic, zygapophyseal articular resurfacing system to provide a long-term solution to pathologies related to the facet joint. This joint plays a pivotal, though not fully elucidated, role in chronic pain, being directly and solely responsible for pain in 9M-26M Americans; facet joint degeneration is found in 57% of adults by the age of 30 and 100% of adults over 60 years old. The proposed work aims to provide deeper understanding of this poorly characterized joint in both sexes and then, following a systematic tissue engineering process, to develop a motion-preserving prosthesis that is both biological and functional.

PI_NAMEs: ATHANASIOU, KYRIACOS A (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;3D Print;Ablation;Acceleration;Address;Adult;Affect;Age;Allogenic;American;Animal Model;Animals;Architecture;articular cartilage;Articulation;Beds;Biochemical;Biological;Biomechanics;Biomimetics;bone;Cartilage;cartilage implant;cartilage regeneration;cartilaginous;Cell Survival;Cells;Chondrocytes;chronic pain;Collaborations;cost estimate;Cytochalasin D;Data;Defect;design;Development;Diagnosis;Direct Costs;Disease;Doctor of Philosophy;efficacy evaluation;Elderly;Engineering;Europe;Exhibits;experience;Facet joint structure;Failure;Female;Foundations;Friction;Future;Hip Prosthesis;Human;human female;Hyaluronidase;Immobilization;Implant;improved;In Situ;in vivo;Inferior;joint destruction;Joint Prosthesis;Joints;Knee;Knee Prosthesis;Libraries;male;mechanical properties;Medial;Methods;mimetics;Miniature Swine;minimally invasive;Modeling;Modulus;Morbidity - disease rate;Morphology;Motion;Nerve Block;novel;novel therapeutics;Nude Mice;Operative Surgical Procedures;osteochondral tissue;Pain;Pathology;Patients;Phase;Phenotype;Play;policy recommendation;preservation;Process;Property;Prosthesis;Prosthesis Implantation;Protein-Lysine 6-Oxidase;Proteins;reconstruction;Replacement Arthroplasty;rib bone structure;Role;scaffold;Secure;self assembly;sex;Shapes;Societies;Spine surgery;Stimulus;Structure-Activity Relationship;success;Surface;Surgeon;System;Temporomandibular Joint;Therapeutic Intervention;Time;Tissue Engineering;Tissues;Vertebral column;Weight-Bearing state;Work;working group

PROJECT_TITLE: Toward tissue engineering of facet cartilage

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Collagen linearization in breast tumors is a key pathogenic event that leads to enhanced tumor cell invasion and metastasis, and to poor prognosis. However, despite its recognized clinical prognostic value, little is known about the mechanisms responsible for collagen linearization. This project will determine the function of novel secreted regulators of collagen linearization and test whether they could be exploited to normalize collagen architecture in tumors and as anti-metastasis therapy.

PI_NAMEs: LABELLE, MYRIAM  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Affect;aggressive breast cancer;Amino Acids;Architecture;Binding;Biological Assay;Blood;Blood Platelets;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Bypass;C-terminal;cancer cell;Cell secretion;Cells;Cessation of life;Circulation;Clinical;clinical prognostic;Collagen;Collagen Fiber;Collagen Type I;Confocal Microscopy;Cysteine;Data;Deposition;Disease;Event;Extracellular Matrix;Extracellular Matrix Proteins;Extravasation;Face;Fibroblasts;Fluorescence;Gene Expression;Generations;Human;Implant;In Vitro;in vivo;Injections;innovation;Invaded;knock-down;Knockout Mice;knowledgebase;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;mechanical force;Mechanics;Mediating;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Microscopy;migration;Modality;Modeling;Molecular;mouse model;multi-photon;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;overexpression;Pathogenicity;patient derived xenograft model;Play;Positioning Attribute;prevent;Primary Neoplasm;Process;Prognosis;prognostic value;Recombinants;Regulation;Role;Scanning Electron Microscopy;second harmonic;Signal Transduction;Site;Stream;Structure of parenchyma of lung;Tail;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;time use;tumor;Tumor Cell Invasion;tumor microenvironment;tumor progression;Tumor Promotion;Veins;Visualization;WISP1 gene

PROJECT_TITLE: Regulation of collagen linearization during cancer progression and metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Evidence from our laboratory have indicated that gut microbiota plays a key role determining outcome for cancer patients treated with immunotherapy, however, the mechanism by which bacteria within the gut can impact immunity at a distant tumor site remains largely obscure. To address these knowledge gaps, during the remainder of my Ph.D. I intend to work towards identifying how the microbially sourced signal reaches the tumor microenvironment, and to determine the key pathways and cell types involved. In my post-doctoral research, I aim to bioinformatically mine patient stool metagenomics for biosynthetic gene clusters associated with response to immunotherapy, and using synthetic biology approaches study the product of these genes to assess immune potentiating or anti-tumorigenic capacity.

PI_NAMEs: FESSLER, JESSICA LYNN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Adjuvant;Affect;anti-cancer;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antibodies;Bacteria;Bacterial Genes;Bacterial Genome;Bacterial Model;Bifidobacterium;Bioinformatics;cancer immunotherapy;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Clinic;Clinical;Clinical Data;cohort;commensal bacteria;Computational Biology;Data;Databases;Dendritic Cells;Disease remission;Distant;Doctor of Philosophy;Engineering;Epithelium;Equilibrium;evidence base;Exhibits;experience;Feces;Future;Gene Cluster;Gene Modified;gene product;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;Health;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Tolerance;Immunity;Immunologic Surveillance;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Intervention;Intestinal Diseases;Intestines;Knowledge;Laboratories;Link;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;Metabolic;Metagenomics;Metastatic Melanoma;Methods;Microbe;microbial;microbiome;microbiota;migration;Mining;Modeling;Mus;Nivolumab;Oral Administration;Outcome;Pathway interactions;patient response;Patients;pembrolizumab;Play;Postdoctoral Fellow;pre-clinical;Process;programmed cell death protein 1;Property;receptor;reconstitution;Research;Research Project Grants;resident commensals;response;Role;Signal Transduction;Site;small molecule;Source;stool sample;success;synthetic biology;System;T cell response;T-Lymphocyte;Testing;Therapeutic;tool;Translating;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Tumor-Derived;tumorigenic;Work

PROJECT_TITLE: Leveraging gnotobiotic models to study the gut microbiota and anti-tumor immunity


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative This proposal aims to evaluate the ability of the cell adhesion molecule Netrin-G ligand 2 (NGL2) to rescue synapses and protect photoreceptors from degeneration. It will also elucidate the molecular composition and signaling mechanisms of synaptic NGL2 complexes and the contributions of NGL2’s interaction partners to synapse maintenance and neuroprotection. To accelerate translation, the proposal examines the function and therapeutic potential of NGL2 and its interaction partners simultaneously in mice and human retinas.

PI_NAMEs: KERSCHENSTEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;Adult;Affect;Anatomy;Award;Behavioral Assay;Biochemistry;Biological Assay;Blindness;Cell Adhesion Molecules;Cell Death;Cessation of life;Code;combinatorial;Communication;Complex;Cone;Data;Development;Disease;Disease Progression;Electrophysiology (science);Functional impairment;functional restoration;gene therapy;Genetic;Genome engineering;Grant;horizontal cell;Human;Image;inherited retinal degeneration;Knock-out;Knockout Mice;Life;Ligands;Maintenance;Mediating;Modeling;Molecular;Mus;Mutation;Natural History;Nerve Degeneration;Nervous System;Nervous System Physiology;neural circuit;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;neuroprotection;Operative Surgical Procedures;Organ Donor;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;photoreceptor degeneration;Photoreceptors;Preparation;preservation;prevent;protein complex;Proteomics;Resolution;Retina;retinal neuron;retinal rods;Rod;Shapes;Signal Transduction;Specific qualifier value;Synapses;synaptic function;synaptogenesis;System;Tertiary Protein Structure;Testing;Therapeutic;Time;transcriptome;translation to humans;Translations;Viral;Virus;Vision;Visual impairment;Wild Type Mouse

PROJECT_TITLE: Synapse rescue and neuroprotection in the retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This application seeks to continue a long-term training program in the Contemporary Approaches to Cancer Cell Signaling and Communication focused on cancer research at the University of California, San Diego, building on an outstanding history of mentoring young scientists to become future leaders in academia and biotech. The faculty includes thirty-two distinguished mentors spanning many areas of biological chemistry, chemical engineering, bioengineering, computational biology, and molecular oncology, who are committed to state-of-the-art laboratory research and training. The overarching mission of this program is to provide training to outstanding pre-doctoral PhD students and post-doctoral scientists in a highly interactive scientific environment in order to prepare them for future high-impact careers in cancer research.

PI_NAMEs: DONOGHUE, DANIEL J;YANG, JING  (contact)

PROJECT_TERMS: cancer cell;Cell Communication;Signal Transduction

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The Indiana University Medical Student Program for Research and Scholarship at the Indiana University School of Medicine has established a pipeline for medical students to enter research intensive programs such as MD/PhD, MD/MS, or gap year programs, and more broadly to encourage them to embrace the career of physician-scientists. The purpose of this T35 renewal program is to continue to sustain this program and to support intensive research training (3 months) for 32 medical students in basic and translational research in the areas of cardiovascular disease, respiratory disease and hematopoiesis with highly trained investigators/mentors and in a stimulating environment.

PI_NAMEs: HERBERT, BRITTNEY-SHEA ;MACHADO, ROBERTO F. (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: anti-cancer research;Award;Awareness;Back;Basic Science;Biomedical Research;Cardiopulmonary;Cardiovascular system;career;centralized portal;Clinical;clinical investigation;Clinical Research;Clinical Sciences;clinical translation;Degree program;design;Disease;Doctor of Philosophy;Education;Enrollment;Environment;experience;Faculty;Fellowship;Fostering;Funding;Generations;Goals;Grant;Hematology;Hematopoietic;improved;Indiana;innovation;interest;Internships;Laboratory Research;Medical Education;medical schools;Medical Students;Medicine;Mentors;Molecular;National Heart, Lung, and Blood Institute;Outcome;Physicians;Positioning Attribute;programs;Publications;recruit;Research;Research Ethics;Research Personnel;respiratory;Scholarship;Science;Scientist;Structure;student participation;student training;Students;Training;Training Programs;Translational Research;Universities

PROJECT_TITLE: Short-Term Training Program In Biomedical Sciences