NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative  Early diagnosis of Alzheimer’s disease (AD) is still challenging, because of the subtlety of the microstructural changes it initially causes in the brain and the difficulty of identifying them with traditional neuroimaging techniques such as PET or CT, and MRI (1.5T, 3T) scans. Recent evidence has revealed that one of the neurodegeneration hallmarks of AD, amyloid-beta plaques is associated with iron accumulation, which can be quantified in vivo through susceptibility MRI techniques. In this proposal, we bring forward a new alternative framework using ultra-high resolution, MR neuroimaging at 7T, wherein this approach will enable the analysis of pathologic markers in AD patients and bring novel insights in our understanding of the mechanisms of AD onset and progression.

PI_NAMEs: ALIPOUR, AKBAR  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;Anatomy;Applications Grants;Autopsy;beta amyloid pathology;Biological;Biological Markers;Brain;brain iron;Brain region;Budgets;career;career development;Clinical;clinical diagnosis;cohort;Communities;Contracts;Control Groups;Data;Data Reporting;Deposition;design;Detection;Development;Diagnosis;diagnostic tool;Disease;Disease Marker;disease prognosis;disease prognostic;Disease Progression;Early Diagnosis;Educational process of instructing;electron density;experience;Exposure to;Functional disorder;Goals;healthy volunteer;Homeostasis;Human;Image;Impairment;improved;in vivo;Individual;insight;interest;Investigation;Iron;Knowledge;lectures;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mentorship;Methods;Microscopic;Microscopy;Nerve Degeneration;Nervous System Disorder;Neuroanatomy;Neurofibrillary Tangles;neuroimaging;neuropathology;Neurosciences;Noise;Normal tissue morphology;novel;Onset of illness;Outcome;Oxidation-Reduction;Pathologic;Pathology;Pattern;Performance;Positron-Emission Tomography;pre-clinical;Predisposition;Production;Professional Competence;Property;Proteins;Protocols documentation;Radiation;radio frequency;radiotracer;recruit;Research;Research Project Grants;Resolution;Scanning;Scientist;Senile Plaques;sex;Signal Transduction;Source;structural imaging;symposium;Techniques;Testing;Time;tissue mapping;Tissues;tool;Training;ultra high resolution;Variant;Visualization;volunteer;Work

PROJECT_TITLE: 7T MRI as a potential tool for detection of pathology in Alzheimer's disease

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE OVERALL We seek to establish the U54 KAPP-Sen Tissue Mapping Center Collaborative with the goal of producing high quality data that would enable SenNet to produce maps of the healthy kidney, adipose tissues, pancreas and placenta across the human lifespan.

PI_NAMEs: GAROVIC, VESNA D;KUCHEL, GEORGE A (contact);MUSI, NICOLAS ;ROBSON, PAUL

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Adipose tissue;Age;Aging;Atlases;Bioinformatics;Biological;Biological Aging;biological heterogeneity;Biological Markers;Biology;Biometry;Biopsy;Boston;Brain Death;Calibration;Cell Aging;Cesarean section;Chronic Disease;Clinic;Clinical;Clinical Trials;Collaborations;Complex;Cytometry;Data;Data Analyses;Dermatology;design;Diabetes Mellitus;Discipline of obstetrics;Donor person;Elderly;Elements;Endocrinology;Ethnic Origin;Evaluation;Fatty acid glycerol esters;flexibility;Future;Generations;Genomic medicine;Genomics;Geriatrics;Geroscience;Goals;Gynecology;Health;Heart;Heterogeneity;Hospitals;Human;human subject;human tissue;Image;Immunohistochemistry;Individual;innovation;insight;Institution;interest;Kidney;Kidney Transplantation;Knowledge;Laboratories;life span;Maps;modifiable risk;multidisciplinary;Nephrology;Outpatients;Pancreas;Pathology;Phase;Phenotype;Placenta;Positioning Attribute;Pregnancy;Program Evaluation;programs;Race;Research;Research Activity;Research Design;Research Personnel;Resources;Risk Factors;RLK5-associated protein phosphatase;sample collection;Sample Size;Sampling;scale up;senescence;senescent cell;senolytics;senomorphic;sex;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;skills;Skin;Skin Tissue;Spatial Distribution;Specific qualifier value;Syndrome;telomere;Thick;tissue mapping;Tissues;transcriptomics;translational study;Translations;United States National Institutes of Health;Woman

PROJECT_TITLE: The KAPP-Sen Tissue Mapping Center Collaborative

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


NIH_SPENDING_CATS: Aging;Clinical Research;Kidney Disease;Women's Health Research

PHR: PROJECT NARRATIVE OVERALL The Administrative Core for the U54 KAPP-Sen Tissue Mapping Center will work closely with NIH staff in providing integrated multidisciplinary leadership for the entire project.

PI_NAMEs: KUCHEL, GEORGE A (contact)

PROJECT_TERMS: Achievement;Address;Adipose tissue;Age;Aging;Area;Biological;Biological Markers;Biology;Boston;Calibration;Cell Aging;Clinic;Clinical Trials;clinically relevant;Collaborations;Data;Data Analyses;Diabetes Mellitus;Discipline;Discipline of obstetrics;Endocrinology;Ensure;Ethnic Origin;Evaluation;Follow-Up Studies;Future;Generations;Genomic medicine;Geriatrics;Geroscience;Goals;Gynecology;Health;Heterogeneity;Hospitals;Human;human subject;human tissue;Individual;innovation;insight;Institution;Kidney;Laboratories;Leadership;Maps;multidisciplinary;Nephrology;novel;Pancreas;Phase;Phenotype;Placenta;Population;Productivity;Program Evaluation;programs;Qualitative Research;Race;Ramp;Research;Research Activity;Research Design;Research Personnel;Resource Allocation;Resources;RLK5-associated protein phosphatase;Sample Size;Sampling;scale up;senescence;Services;sex;single cell technology;Site;skills;Skin;Skin Tissue;Spatial Distribution;Surveys;Thick;tissue mapping;Tissues;Transplantation Surgery;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE – BIOSPECIMEN/PATHOLOGY CORE This core will store all samples collected in the three projects in a central location. This core will also coordinate uniform evaluation of all samples in a pathology laboratory. This core will also send samples, as directed, for analysis within the SPORE and also to researchers worldwide.

PI_NAMEs: FOROUD, TATIANA M. (contact)

PROJECT_TERMS: Address;Anatomy;Animals;Award;biobank;Biological;Biological Specimen Banks;Blood specimen;Catalogs;Central Nervous System Neoplasms;Clinic;Communication;Communication Tools;Communities;Data;Development;Diagnosis;Diagnostic;digital pathology;disease model;Disease susceptibility;Electronics;Ensure;Evaluation;Fatty acid glycerol esters;Future;Genomics;geographic barrier;Goals;Human;hyperactive Ras;Image;imaging study;In Vitro;Laboratories;Lead;leukemogenesis;Location;Malignant Childhood Neoplasm;Malignant Neoplasms;Microscopy;Molecular;Mus;Necrosis;Neurofibromatosis 1;Normal tissue morphology;novel therapeutics;Organ;Pathogenesis;Pathologic;Pathologist;Pathology;pathology imaging;Patients;Peripheral Nervous System;Photomicrography;Play;Procedures;programs;Protocols documentation;Quality Control;Recurrent disease;Research;Research Personnel;Residual state;Resources;Retrieval;Risk;Role;Sampling;Sarcoma;Signal Pathway;Stains;Standardization;success;Technology;Text;Time;Tissue Sample;Tissue Stains;Tissues;treatment response;tumor;Update;virtual;web site

PROJECT_TITLE: Biospecimen and Pathology Core


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Women's Health Research

PI_NAMEs: MUSI, NICOLAS  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Age;Age related pathologies;Atlases;Biology of Aging;Brain Death;Cell Aging;Cells;Cesarean section;Collaborations;Collection;Computing Methodologies;Consent;Cross-Sectional Studies;Cytometry;Data;data sharing;Enrollment;Ensure;Environment;Ethnic Origin;Funding;Future;healthy aging;healthy volunteer;Heart;Image;Individual;individual variation;islet;Kidney;kidney cortex;Kidney Transplantation;Laboratories;Literature;Maps;member;men;Molecular;Mothers;open data;Organ;Pancreas;Placenta;Procedures;programs;racial diversity;Research;Research Personnel;Resources;RLK5-associated protein phosphatase;Role;Sampling;senescence associated secretory phenotype;senescent cell;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Skin;Skin Tissue;Socioeconomic Status;Specimen;subcutaneous;success;Technology;Thick;Time;tissue mapping;Tissue Sample;Tissues;transcriptomics;Umbilical cord structure;United States National Institutes of Health;Visceral;Woman;Work

PROJECT_TITLE: Biospecimen Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_STATE: NY

PHR: Narrative (public health relevance statement): The grim prognosis and lack of therapeutic options for glioblastoma highlight the urgency of not only working towards developing novel treatment modalities but, in parallel, working on enhancing the efficacy of existing radiation and immunotherapy. By using a genetically engineered immunocompetent model of glioblastoma subtypes and primary human PDX models, this application aims to establish whether IL-1β serves as a compelling novel GBM anti-edema and anti-neoplastic therapy that is devoid of the severe side effects of DEX and anti-VEGFA; thus, it will have a significant impact on this disease.

PI_NAMEs: HAMBARDZUMYAN, DOLORES  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Address;Adrenal Cortex Hormones;Anatomy;anti-cancer;anti-tumor immune response;Antibodies;Antibody Therapy;Antineoplastic Agents;Area;Automobile Driving;Avastin;Binding;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain Neoplasms;CD8-Positive T-Lymphocytes;cell type;Cellular biology;cellular targeting;Cerebral Edema;Chronic;Clinical;Complication;Data;Dexamethasone;Diabetes Mellitus;Diagnosis;Disease;Dose;Edema;efficacy evaluation;Endothelial Cells;epidermal growth factor receptor VIII;exhaust;Exhibits;Frequencies;Genetic;Genetic Engineering;Genetically Engineered Mouse;Glioblastoma;Glioma;Human;human disease;Hypoxia;Immune response;Immunocompetent;Immunotherapy;in vivo;Individual;Infiltration;Inflammatory;insight;Interleukin-1 beta;Invaded;Link;Lymphoid;Macrophage;Malignant Neoplasms;Mediating;Mental Depression;Mesenchymal;Modality;Modeling;Molecular Biology;Molecular Target;monocyte;Morbidity - disease rate;mouse model;Mus;Myopathy;Neoplasms;NF1 gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;overexpression;Pathology;patient derived xenograft model;Patients;PDGFB gene;Pericytes;Perioperative;pharmacologic;Production;Prognosis;Proteins;Psychoses;public health relevance;Publishing;Radiation;Radiation therapy;Resistance development;Role;Severities;side effect;Signal Transduction;Steroids;targeted agent;Testing;Therapeutic;therapy resistant;Tight Junctions;Time;tool;Toxic effect;traditional therapy;Treatment Efficacy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vasogenic Cerebral Edema;vasogenic edema;VEGFA gene;Work

PROJECT_TITLE: Tumor-associated macrophages in vasogenic cerebral edema in brain tumors

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Understanding the regulation of hair follicle stem cells and progenitors during the hair cycle is a crucial requirement for future hair regenerative therapies. We will systematically define the functions of the follicle- lining dermal sheath, a largely overlooked and understudied cell population, in regulating follicle regression. This work will expand our knowledge of stem cell and progenitor regulation by dermal sheath cells, which may be useful for the development of HF regeneration approaches.

PI_NAMEs: RENDL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;base;Biological Assay;Calcium;Calcium Signaling;Cell Communication;Cells;Cessation of life;Color;Contracts;Data;Dedications;Dermal;Development;Endothelin;Endothelin-1;epithelial stem cell;Epithelium;Funding;Future;Genetic;genetic signature;Germ;germline stem cells;Goals;Growth;Hair;Hair follicle structure;hair regeneration;Hair shaft structure;Image;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;in vivo;inhibitor;intravital imaging;Knock-out;Knowledge;Ligands;Location;Maps;member;Mesenchymal;Mesenchyme;meter;Methods;Molecular;molecular dynamics;Mus;Muscle Contraction;Natural regeneration;novel;Pathway interactions;Peptides;pharmacologic;Phase;Physiological;Population;Positioning Attribute;Process;progenitor;receptor;regenerative therapy;Regulation;Regulatory Pathway;Reporter;Rest;rho;Role;Sarcoplasmic Reticulum;Science;Signal Pathway;Signal Transduction;Skin;small molecule inhibitor;Smooth Muscle;Specific qualifier value;stem cell differentiation;stem cell function;stem cell proliferation;stem cells;Study models;System;Testing;tongue papilla;transcriptome;two photon microscopy;vasoconstriction;Vasoconstrictor Agents;Visualization;voltage;Work

PROJECT_TITLE: Specification, Molecular Control and Niche Functions of the Hair Follicle Mesenchyme

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


PHR: NARRATIVE (Project 1) Plexiform neurofibroma (PNF) and their progression to malignant peripheral nerve sheath tumor (MPNST) is the leading cause of morbidity and premature death in patients with neurofibromatosis type 1. This project leverages patient derived samples, genetically engineered mouse models, and state-of-the art tools in systems biology to inform the clinical translation of molecularly targeted therapies across the PNF-to-MPNST continuum.

PI_NAMEs: CLAPP, DAVID W (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;Aftercare;anti-cancer treatment;Award;Benign;Biological;Biology;Biopsy Specimen;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Caring;Cause of Death;CDKN2A gene;Cessation of life;Characteristics;chemotherapy;Childhood;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;Collagen;Combined Modality Therapy;Complex;Data;Deformity;Development;early phase clinical trial;Evaluation;Event;Evolution;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Funding;Genetic study;Genetically Engineered Mouse;Genome;Genomics;Germ Lines;Goals;Heterozygote;Histologic;Human;hyperactive Ras;improved;In complete remission;Indolent;inhibitor;insight;Investigational Therapies;Laboratories;Lesion;Maintenance;Malignant - descriptor;MEKs;Modeling;Molecular Analysis;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;multimodality;mutant;Mutation;Neoplastic Schwann Cell;Nerve;Nerve Sheath Tumors;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Paralysed;Pathology;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;phase II trial;Play;Plexiform Neurofibroma;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical study;premalignant;premature;prevent;Prevention;Preventive;programs;Property;PTPN11 gene;Radiation;Reading Frames;Refractory;Research Personnel;response;Role;Sampling;Sarcoma;Schwann Cells;Signal Transduction;Structure;synergism;Systems Biology;Technology;Testing;Therapeutic;Therapeutic Studies;therapeutic target;tool;transcriptome;Translating;translational study;Translations;tumor;tumor initiation;tumor microenvironment;tumorigenic

PROJECT_TITLE: PROJECT 1: From Neurofibroma to MPNST: Models, Biology and Translation to Clinic


NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Affect;Age;Aging;analysis pipeline;Atlases;Benchmarking;Biological;Biological Markers;Cells;Charge;Classification;Clinical Data;Collaborations;Common Data Element;Communities;Complex;Computer Analysis;computerized data processing;Computing Methodologies;Cytometry;Data;Data Analyses;Data Coordinating Center;data integration;data management;data modalities;Data Set;data sharing;data sharing networks;deep learning;design;Development;Ensure;Evaluation;FAIR principles;Fatty acid glycerol esters;Genomics;Heterogeneity;high dimensionality;Histopathology;Image;imaging Segmentation;Individual;Kidney;Lead;Leadership;Linear Models;Maps;Methods;neural network;Output;Pancreas;Pathway Analysis;Patients;Pattern;Placenta;Policies;Population;Procedures;Process;prospective;Proteins;Proteomics;Quality Control;Reproducibility;Research;Resolution;RLK5-associated protein phosphatase;Sampling;Secure;senescence;senescent cell;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;spatial integration;Standardization;Testing;tissue mapping;Tissues;transcriptome;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Data Analysis Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: The proposed studies will demonstrate a shared mechanism for phosgene and phosphorus trichloride toxicity mediated by degradation of plasmalogen phospholipids, which will be tested as a mechanism responsible for barrier dysfunction in endothelium and epithelium. Additional untargeted omics approaches will be employed to discover additional mediators and mechanisms. These studies may provide targets for therapeutic countermeasures to phosgene and phosphorus trichloride exposures.

PI_NAMEs: EDWARDS, JAMES L;FORD, DAVID A. (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accidents;Acids;Acute Lung Injury;airway epithelium;Aldehydes;Amines;Apnea;chemical countermeasure;Chemical Warfare;Chemical Warfare Agents;Chemical Weapons;Chemicals;Chlorides;Data;Development;diene;Dose;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Esterification;ethanolamine plasmalogens;Exposure to;Family;fatty aldehyde;Flame Retardants;Functional disorder;functional group;Future;Goals;Herbicides;Human;Industrial Accidents;Industrialization;Industry;Inhalation Exposure;insight;Lethal Dose 50;lipidomics;Lipids;lipophilicity;Lung;lung microvascular endothelial cells;Lysophospholipids;Masks;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolomics;Molecular;Morbidity - disease rate;mortality;Mus;Mustard Agent;novel;Oils;Pathway interactions;Permeability;Pesticides;Phosgene;Phospholipids;Phosphorus;Plasma;Plasmalogens;plasmenylethanolamine;Plasticizers;Polyunsaturated Fatty Acids;Polyurethanes;Production;programs;Proteins;Public Health;Pulmonary Edema;Pulmonary Surfactants;Rattus;Reaction;Regimen;Research;response;Role;Schedule;Shipping;small molecule libraries;symposium;targeted treatment;Terrorism;Testing;Therapeutic;therapeutic target;Time;Toxic effect;toxicant;vinyl ether;Water

PROJECT_TITLE: Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Adipocytes;Adipose tissue;Age;aged;Aging;Antibodies;Biological;Biological Assay;Biological Markers;Biology;Blood;Cell Aging;Cells;Cellular biology;Collaborations;Cytometry;Data;Data Analyses;Data Set;design;Development;Dissociation;Drug Targeting;Drug usage;Ensure;epigenomics;Epitopes;experience;experimental study;Faculty;Formalin;Foundations;functional gain;Gene Expression;high resolution imaging;Human;Human BioMolecular Atlas Program;human model;human tissue;Huntington gene;Image;imaging approach;induced pluripotent stem cell;insight;Islet Cell;Kidney;Knowledge;Laboratories;Maps;Measures;member;Messenger RNA;meter;Methods;Modeling;Molecular;mouse model;novel;old mice;Pancreas;Paraffin Embedding;Pharmaceutical Preparations;Placenta;Population;Preparation;Protein Secretion;Research;Research Personnel;Resolution;response;RLK5-associated protein phosphatase;Running;senescence;senescent cell;senolytics;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Standardization;stem cell model;success;System;Techniques;Tissue Embedding;tissue mapping;Tissue Model;Tissues;tool;Transcriptional Regulation;transcriptome;transcriptomics;treatment response;Work

PROJECT_TITLE: Bio-Analysis Core


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Studies from our laboratory showed nanoformulation engineered for targeting HuR oncoprotein modulates immune-associated proteins and pathways in lung cancer. The proposal focuses on understanding and developing strategies to exploit the immune modulatory effects to stimulate a robust antitumor activity against lung cancer.

PI_NAMEs: RAMESH, RAJAGOPAL  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Animal Model;Animals;anti-cancer;anti-PD-L1;anti-PD-L1 therapy;anticancer activity;Antigens;Antineoplastic Agents;Antitumor Response;Apoptotic;Binding Proteins;Binding Sites;Breast Cancer Cell;Cancer Biology;cancer cell;Cancer cell line;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer therapy;Cell Cycle Arrest;Cell Death;cell motility;Cell Physiology;Cell Proliferation;Cells;chemotherapy;Cisplatin;Clinical;clinical translation;CTLA4 gene;Data;Dendrimers;Development;Disease Progression;Drug resistance;effective therapy;efficacy study;Embryo;Engineering;Exhibits;Gene Delivery;Genetic;Growth;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunoglobulins;Immunology;immunoregulation;Immunotherapy;In Vitro;in vivo;inhibitor;innovation;Invaded;Laboratories;lipid nanoparticle;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;member;Messenger RNA;Micrometastasis;Modeling;Molecular;Molecular Target;molecular targeted therapies;mRNA Expression;Mucins;multidisciplinary;Mus;Mutagens;nanoengineering;nanoformulation;nanoparticle;nanotherapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncoproteins;overexpression;Pathology;Pathway interactions;patient subsets;pharmacologic;pointed protein;preclinical study;programmed cell death ligand 1;programmed cell death protein 1;Promoter Regions;protein expression;Protein Family;Proteins;Radiation therapy;Radiosensitization;Recurrent disease;Reporting;Research Personnel;Resistance;Signal Transduction;siRNA delivery;Small Interfering RNA;statistics;Survival Rate;T cell response;T-Lymphocyte;targeted cancer therapy;targeted treatment;Testing;Therapeutic;Tissues;TNFSF10 gene;Treatment Failure;Treatment outcome;tumor;tumor eradication;tumor growth;tumor heterogeneity;Vision

PROJECT_TITLE: Engineered Nanoformulation for Immune-modulation in Cancer

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurofibromatosis;Neurosciences;Rare Diseases

PHR: NARRATIVE (Project 2) Individuals with NF1 have a high incidence of glioma. Also, the NF1 gene mutation is present in approximately 20-25% of sporadic high-grade gliomas. These NF1 mutant gliomas are aggressive and have no effective treatments. Through the use of sophisticated experimental models and molecular profiling of clinically annotated patient tumor biopsies, we will explore unique features of NF1 mutant gliomas also leveraging recent advances in PNST treatment.

PI_NAMEs: PARADA, LUIS FERNANDO (contact)

PROJECT_TERMS: Address;Allografting;Biopsy;Body System;Cell Line;Cells;Characteristics;Clinical;Clinical Data;cohesion;Collaborations;Communities;Development;Disease;Drug Screening;drug sensitivity;effective therapy;efficacy testing;Engineering;Equilibrium;Evolution;experience;Experimental Models;experimental study;Formalin;Gene Mutation;Genetic;Genetically Engineered Mouse;Genomics;Genotype;Germ Lines;Glioblastoma;Glioma;Goals;Heterozygote;Histologic;Human;human tissue;hyperactive Ras;immune cell infiltrate;Immune response;Immune system;Immunologics;Immunotherapy;In Vitro;in vivo;Incidence;Individual;Inflammatory;Inflammatory Response;Infrastructure;International;Link;LoxP-flanked allele;Malignant neoplasm of brain;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Microglia;Modeling;Molecular;Molecular Analysis;Molecular Profiling;mouse model;Mus;mutant;Mutate;Mutation;Natural History;neoplastic cell;NF1 gene;NF1 mutation;NF1 related tumorigenesis;Paraffin Embedding;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient advocacy group;patient derived xenograft model;Patients;Penetrance;Persons;Pharmaceutical Preparations;Phenotype;Pre-Clinical Model;preclinical study;Predisposition;Property;Proteomics;PTEN gene;Published Comment;recruit;research clinical testing;Research Personnel;Resources;response;Role;Sampling;Signal Pathway;Site;Stratification;Subgroup;Suggestion;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;TP53 gene;translational impact;tumor;Tumor Expansion;tumor microenvironment;Tumor Suppressor Genes;tumor-immune system interactions;Work;Xenograft procedure

PROJECT_TITLE: PROJECT 2: NF1-associated Glioblastoma


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sharing the brain images and genomic data from stroke patients provides a unique resource to discover new treatments that can reduce the injury caused by strokes, if we can make the images findable, accessible, interoperable, and reusable (FAIR) so that investigators from around the world can study them. With prior NIH support we built the Cerebrovascular Knowledge Portal (CDKP) to share genetic data. We now propose to build the imaging CDKP (iCDKP) to enable investigators to study these data for insights that will someday lead to new treatments that can prevent strokes, reduce the damage a stroke causes, or help the brain recover from a stroke.

PI_NAMEs: MARCUS, DANIEL SCOTT;ROSAND, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: FARACO, CARLOS CESAR

PROJECT_TERMS: Acceleration;Acute;Affect;Biological;Brain;Brain Edema;Brain hemorrhage;Brain imaging;Brain Ischemia;brain tissue;Cause of Death;cerebrovascular;Cerebrovascular Disorders;cerebrovascular imaging;Chronic;Clinical;Clinical Data;Clinical Investigator;Communities;Consultations;Data;data harmonization;data management;data privacy;data repository;data reuse;Data Scientist;Data Set;data sharing;data submission;Deterioration;digital;disability;drug candidate;Edema;Educational workshop;effective therapy;Ensure;Ethics;Face;FAIR principles;Funding;Future;Genetic;genomic data;Genomics;Grant;Growth;Guidelines;Hemorrhage;Human Genetics;Image;image archival system;imaging modality;Individual;Infarction;Infrastructure;Ingestion;Injury;insight;International;Ischemia;Knowledge Portal;Lead;Letters;Licensing;Link;Location;Magnetic Resonance Imaging;Medical Care Costs;Metadata;Mission;Monitor;Morbidity - disease rate;MRI Scans;Names;National Institute of Neurological Disorders and Stroke;neuroimaging;novel;Online Systems;open data;open source;outreach;Pathway interactions;Patients;Persons;Pharmacotherapy;Phenotype;phenotypic data;Physiology;Policies;Population Heterogeneity;Prevention;Procedures;Process;Process Measure;programs;Quality Control;Recovery;repository;Reproducibility;Research;Research Personnel;Resources;response;response to brain injury;risk variant;Sample Size;serial imaging;Standardization;Stroke;stroke incidence;stroke patient;Stroke prevention;stroke therapy;Structure;symposium;Time;Tissues;Training;U-Series Cooperative Agreements;Underserved Population;United States National Institutes of Health;Universities;usability;vascular cognitive impairment and dementia;Washington;X-Ray Computed Tomography

PROJECT_TITLE: An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The neurobiological mechanisms underlying symptoms of withdrawal are poorly understood despite the fact that they serve as potent triggers for relapse in individuals attempting to remain abstinent from alcohol. While our recent work uncovered a role for the rostromedial tegmental nucleus (RMTg) in regulating withdrawal symptoms, the broader neural circuitry that governs this effect remains unknown. The proposed project will interrogate the mechanistic involvement of input from the lateral habenula to the RMTg in symptoms of withdrawal and in doing so provide an opportunity to identify new potential therapeutic targets for the development of drugs to treat withdrawal symptoms.

PI_NAMEs: GLOVER, ELIZABETH J (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acute;acute symptom;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;anxiety-like behavior;Attenuated;behavior test;Behavioral;Brain;Brain region;Cell Nucleus;cholinergic;Chronic;Consumption;Data;Decision Making;design;Development;drug development;Electrophysiology (science);emotional symptom;Ethanol;Exhibits;experimental study;flexibility;Genetic;genetic approach;Glutamates;Habenula;Health;Hour;Human;Hyperactivity;Hyperalgesia;Impaired cognition;Impulsivity;in vivo;Individual;innovation;insight;Lateral;Link;Literature;Measures;Mechanics;Mediating;Methodology;Midbrain structure;negative affect;neural;neural circuit;neuroadaptation;neurobiological mechanism;Neurobiology;Neurons;neurotransmission;optogenetics;Pain;pain sensitivity;pharmacologic;physical symptom;Physiological;Physiology;Play;preclinical study;Public Health;Rattus;Regulation;Relapse;relapse prevention;Role;Signal Transduction;Slice;sobriety;symptom treatment;Symptoms;Testing;therapeutic target;Time;Viral;Withdrawal;Withdrawal Symptom;withdrawal-induced anxiety;Work

PROJECT_TITLE: Role of RMTg afferents in mechanisms of withdrawal from chronic ethanol exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PRPOJECT NARRATIVE The goals of this translational research project are to develop new treatments the target the molecular pathways that cause juvenile myelomonocytic leukemia (JMML). This aggressive cancer responds poorly to chemotherapy and is much more common is children with neurofibromatosis type 1 (NF1). In addition to treating JMML patients with targeted inhibitors, we will investigate the molecular mechanisms of response and will seek to validate candidate biomarkers of response and resistance.

PI_NAMEs: SHANNON, KEVIN M. (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Alleles;Azacitidine;Behavior;Biological;Biological Assay;Biological Models;Bromodomains and extra-terminal domain inhibitor;candidate validation;CBL gene;Cells;chemotherapy;Child;Clinical;clinical translation;Clinical Trials;Collaborations;conditional mutant;Data;Development;Diagnosis;Diagnostic;Diagnostic tests;DNA Methylation;Dysmyelopoietic Syndromes;Enrollment;Epigenetic Process;Europe;European;founder mutation;Funding;Gene Frequency;Gene Targeting;Genes;Genetically Engineered Mouse;Genotype;Germ Lines;Goals;Hematopoietic;Hematopoietic Stem Cell Transplantation;high risk;hyperactive Ras;Hypermethylation;improved;Infant;inhibitor;innovation;Insertional Mutagenesis;Intervention;Japan;Juvenile Myelomonocytic Leukemia;kinase inhibitor;KRAS2 gene;KRASG12D;Laboratory Study;Malignant Neoplasms;MEKs;methylation pattern;Modeling;Molecular;Molecular Genetics;molecular targeted therapies;Monitor;Mus;mutant;Mutant Strains Mice;Mutation;Myeloproliferative disease;Neurofibromatosis 1;Newly Diagnosed;next generation;NF1 gene;novel;novel marker;Oncogenic;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phase II Clinical Trials;pre-clinical;preclinical study;preclinical trial;predictive marker;Prognosis;PTPN11 gene;Ras/Raf;Refractory;Relapse;Reproducibility;Research Project Grants;Resistance;response;response biomarker;risk stratification;Role;Sampling;Signal Transduction;Somatic Mutation;Specimen;standard of care;Transgenes;translational goal;Translational Research;tumor;Tumor Suppressor Genes;Work;working group

PROJECT_TITLE: PROJECT 3: A High Content Clinical Trial of the MEK inhibitor Trametinib in JMML


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Avoidant/restrictive food intake disorder (ARFID)—which affects 1-4% of adults—is a severe mental illness that causes people to eat an insufficient volume or variety of food and puts them at risk for nutritional deficiencies, low weight, psychiatric comorbidity, and suicidality. This multidisciplinary study offers an important opportunity to examine how underlying abnormalities in endocrine signalling and neural circuitry contribute to phenotypic presentations in adults. This innovative project has significant potential to reduce the public health burden of ARFID by informing pathophysiology and identifying mechanistic treatment targets hormonal agonist/antagonist medications and for brain stimulation therapies.

PI_NAMEs: HOLSEN, LAURA MCGRATH;LAWSON, ELIZABETH AUSTEN;THOMAS, JENNIFER JOANNE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Adolescent;Adult;Affect;Age;age group;Agonist;Allergic Reaction;Amygdaloid structure;antagonist;Anterior;Appetite Stimulants;Area Under Curve;Arousal;avoidant restrictive food intake disorder;Behavioral;behavioral phenotyping;Body mass index;Body Weight decreased;Brain;Central Nervous System;Child;Choking;Cholecystokinin;Chronic;cingulate cortex;Clinical;Clinical Psychology;cognitive system;cohort;Cues;Data;data archive;Dependence;dietary supplements;Dimensions;Disease;Distress;Eating;Eating Disorders;Endocrine;Evidence based treatment;Exhibits;experience;feeding;Feeling;Food;food restriction;Fright;Functional disorder;gastrointestinal;ghrelin;gray matter;Homeostasis;Hormonal;Hormones;Hydrocortisone;Hyperactivity;Hypothalamic structure;Impairment;Individual;innovation;Intake;interest;Interest Group;Intervention;Investigation;life span;Magnetic Resonance Imaging;Malnutrition;medical complication;men;Mental Health;Modeling;Motor Cortex;multidisciplinary;National Institute of Mental Health;Negative Valence;neural circuit;Neurobiology;Neuroendocrinology;neuroregulation;Neurosciences;novel;Oxytocin;Perception;Persons;Pharmaceutical Preparations;Phenotype;precision medicine;psychiatric comorbidity;psychosocial;Public Health;Reporting;Research;Research Domain Criteria;response;Risk;secondary analysis;Sensory Disorders;severe mental illness;Severities;sex;Signal Transduction;somatosensory;Somatosensory Cortex;Standardization;Stimulus;Stress;suicidal;Taste aversion;Time;Treatment outcome;Vegetables;Visual;Vomiting;Weight;Woman;Work;Youth

PROJECT_TITLE: Neurobiological Underpinnings of Avoidant/Restrictive Food Intake Disorder in Adults

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


PHR: PROJECT NARRATIVE The objective of the Developmental and Hyperactive Ras Tumor (DHART) SPORE Developmental Research Program (DRP) is to support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germline and somatic NF1 mutations. The DRP will accomplish this goal by funding rigorous translational research in the areas of population science, therapeutics, and mechanisms of and by facilitating collaborative interactions between DRP-funded scientists and other SPORE investigators. The translational studies supported by the DRP have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives.

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;anti-cancer research;Applications Grants;Area;Basic Science;California;Cancer Center;career;Clinical;Clinical Sciences;Collaborations;Communities;Country;Data;Department of Defense;Development;Diagnosis;disability;Discipline;Disease;Early treatment;effective therapy;Ethnic Origin;Evaluation;expectation;faculty support;Funding;Funding Agency;Germ Lines;Goals;Health Sciences;high reward;high risk;Human;Human Development;hyperactive Ras;improved;Indiana;innovation;Institution;Investments;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;minority investigator;Mission;National Cancer Institute;neoplasm therapy;Neurofibromatoses;NF1 gene;NF1 mutation;Pediatric Hospitals;Pediatric Oncology;Philadelphia;Pilot Projects;Population Sciences;Predisposition;Process;Productivity;professor;programs;Race;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;San Francisco;Scientist;Senior Scientist;Sex Orientation;Signal Transduction;Syndrome;Talents;Techniques;Texas;Therapeutic;translational cancer research;Translational Research;translational study;tumor;Tumor stage;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Lung

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Computed tomographic pulmonary angiograms (CTPA) for pulmonary embolism (PE) are ordered in nearly 2% of all 120 million Emergency Department visits in the United States each year; however, many of these are avoidable. Despite prior research in this area, unnecessary testing remains common and subjects patients to additional costs, ionizing radiation, risk of anaphylaxis from contrast dye, and harms from overdiagnosis and overtreatment. To improve the quality and efficiency of care for patients with suspected PE, this investigation will refine, pilot, and evaluate the acceptability and appropriateness of an empirically-derived multi-dimensional strategy that targets unique barriers to de-implementing low- value imaging.

PI_NAMEs: WESTAFER, LAUREN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accident and Emergency department;Address;Administrator;Advisory Committees;Algorithms;American;American College of Physicians;American College of Radiology;Anaphylaxis;Angiography;Area;Behavior;behavior change;Belief;Benchmarking;career development;Caring;Chest;Clinical;clinical decision support;cognitive testing;college;Communities;cost;Data;Deimplementation;design;Development Plans;Diagnosis;Dimensions;Dyes;Education;Effectiveness;Electronic Health Record;Elements;Emergency Department Physician;Emergency department visit;Emergency Medicine;Emotions;empowerment;Ensure;Evaluation;evidence base;Evidence based practice;experience;Feedback;Fright;Goals;Guidelines;Health system;Image;imaging study;implementation barriers;implementation facilitators;implementation framework;implementation science;implementation strategy;improved;Informatics;innovation;insight;Institution;Intervention;Interview;Investigation;Ionizing radiation;K-Series Research Career Programs;Knowledge;Learning Module;Lung;lung imaging;Massachusetts;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Multicenter Trials;National Heart, Lung, and Blood Institute;novel;organizational climate;overtreatment;Patient Care;Patients;Peer Pressure;Performance;Physicians;Pilot Projects;podcast;Positioning Attribute;practice setting;prototype;Provider;provider behavior;Pulmonary Embolism;Recommendation;Reporting;Research;Research Personnel;Risk;risk stratification;Safety;social influence;Societies;Structure;success;Surveys;Technical Expertise;Testing;theories;tomography;tool;Training;trial design;United States;usability;user centered design;Work;X-Ray Computed Tomography

PROJECT_TITLE: De-Implementation of Low Value Imaging in Pulmonary Embolism (DELVE PE)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The R25 YES Program, under the auspices of the Case CCC will develop and implement cancer education, research immersion, community outreach and curriculum development targeted at middle school, high school and undergraduate college students, as well as to their teachers, families and friends to foster better understanding of the cancer process, promote risk reduction strategies, encourage elimination of cancer disparities and stimulate pursuit of careers in cancer research and healthcare delivery.

PI_NAMEs: JACKSON, MARK W. (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Active Learning;Age;anti-cancer research;Applications Grants;Area;Award;Bachelor's Degree;Biomedical Research;Black race;cancer care;cancer education;cancer health disparity;cancer prevention;cancer risk;Cancer Science;career;Caring;Cities;Collaborations;college;community engagement;Community Outreach;Comprehensive Cancer Center;curriculum development;curriculum enhancement;Depressed mood;design;disparity elimination;Disparity population;Education;Education Projects;Educational Activities;Educational Curriculum;Educational process of instructing;Ethnic Origin;Ethnic Population;experience;Faculty;faculty mentor;Family;family building;Fostering;Friends;Funding;Goals;graduate school;Grant;health care delivery;health care disparity;health disparity;Health Promotion and Education;Healthcare;high school;High School Faculty;High School Student;Hispanic;Household;Immersion;improved;Income;innovation;interest;Intervention;junior high school;Knowledge;Learning;Malignant Neoplasms;medical schools;member;Mentors;Mentorship;metropolitan;Middle School Student;minority communities;Minority Groups;Ohio;outreach;Population;Poverty;Prevention Research;Process;programs;Psychological reinforcement;Research;Research Personnel;Risk Reduction;school district;Schools;Science;science teacher;skills;Students;suburb;teacher;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;urban school;Work;Youth

PROJECT_TITLE: Case CCC Youth Engaged in Science, 09/01/2022-08/31/2027

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


PHR: PROJECT NARRATIVE – CAREER ENCHANCEMENT PROGRAM The Developmental and HyperActive Ras Tumor (DHART) SPORE Career Enhancement Program (CEP) supports faculty at the Instructor and Assistant Professor levels to engage in translational research focused on developing treatments for tumors characterized by mutations in NF1. The CEP recruits early stage investigators, with a special emphasis on recruiting underrepresented minority investigators, and provides financial and scientific support (via core expertise and facilities), and structured mentorship from SPORE scientists to accelerate CEP awardee development into independent researchers in the field of cancer biology and therapeutics related to NF1.

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Award;Basic Science;California;Cancer Biology;Cancer Center;cancer therapy;career;career development;Career Mobility;Child;Clinical;Clinical Investigator;clinical outcome assessment;Clinical Sciences;clinical translation;Collaborations;Communication;Communities;Data;Dedications;design;Development;developmental disease;disability;Discipline;Disease;early-career faculty;Education;effective therapy;efficacy validation;Ensure;Ethnic Origin;Extramural Activities;Faculty;faculty support;Feedback;Foundations;Funding;Funding Opportunities;Future;Goals;Health Sciences;Historically Black Colleges and Universities;Human;Human Development;hyperactive Ras;Indiana;Individual;Infrastructure;innovation;Institution;instructor;International;Knowledge;Leadership;Link;Malignant Neoplasms;meetings;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;minority investigator;Mission;Monitor;Mutation;National Cancer Institute;Nature;neoplasm therapy;neuro-oncology;Neurofibromatoses;next generation;NF1 gene;NF1 mutation;Pathology;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;pharmacokinetics and pharmacodynamics;Philadelphia;Pre-Clinical Model;preclinical study;Process;Professional Organizations;professor;Program Development;programs;Race;recruit;Request for Applications;Research;Research Personnel;Resources;Role;San Francisco;Schedule;Science;Scientist;senior faculty;Sex Orientation;Signal Transduction;Site;skills;Societies;Structure;success;Talents;Texas;Textiles;Therapeutic;Therapeutic Trials;Training;Training Programs;Translational Research;translational scientist;tumor;Underrepresented Minority;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study is the first to systematically evaluate the efficacy of single and combined academic accommodation, behavioral treatment, and medication treatment in a large sample of children with ADHD. Using a scientifically rigorous, cross-over design the impact of these approaches on ecologically valid measures of outcome (on- task behavior, quiz scores, academic productivity) will be assessed to inform effective school intervention.

PI_NAMEs: FABIANO, GREGORY A (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;academic standard;Academic support;Achievement;Americans with Disabilities Act;Area;Attention;Attention deficit hyperactivity disorder;Behavior;behavior measurement;behavior observation;Behavior Therapy;Behavioral;Characteristics;Child;Child Support;Civil Rights;Classification;Combined Modality Therapy;common treatment;comorbidity;Compensation;Crossover Design;design;Diagnosis;Diagnostic Procedure;Disruptive Behavior Disorder;distraction;Education;Educational accommodation;educational atmosphere;effective intervention;Effectiveness;efficacy evaluation;efficacy study;Environment;Equus caballus;Evaluation;evidence base;Exhibits;experience;functional improvement;Furniture;Guidelines;Heterogeneity;Impairment;improved;Individual;Individual Differences;Individuals with Disabilities Education Act;Inferior;Instruction;Intervention;Investigation;Laboratories;Learning;Learning Disabilities;learning outcome;Literature;marginalization;Measures;Medical;Neurocognitive;Neurocognitive Deficit;Outcome;Outcome Measure;Outsourcing;Participant;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Placebos;Policies;policy recommendation;processing speed;Productivity;Reaction Time;Recommendation;remediation;Research;Research Design;response;Ritalin;Role;Sampling;Schools;Short-Term Memory;Site;social;Stimulant;Students;Symptoms;System;Testing;Time;treatment effect;Treatment Efficacy;treatment program;treatment response;Work

PROJECT_TITLE: Single and Combined Effects of Positive Behavior Support, Medication and Academic Accommodation for Children with ADHD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: The mechanism controlling the time and place where messenger RNA is activated to make proteins is unknown, yet this problem is at the heart of all cell function and at the basis of neurological diseases and cancer. We have devised a variety of technologies to answer this question, using transgenic animals, innovative microscopy and unique mRNA tagging strategies to determine where the critical events occur in the cell. We will use this methodology on neurons, where the local activation of protein synthesis at synapses is at the basis of learning and memory.

PI_NAMEs: DAS, SULAGNA ;SINGER, ROBERT H (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 3' Untranslated Regions;Actins;Address;Affect;Antibodies;base;Behavior;beta Actin;Binding;Binding Proteins;Brain;brain tissue;Breeding;Caring;Cell Physiology;Cells;Color;Complex;Cytoplasmic Granules;Dendrites;Environment;Epitopes;Event;Fluorochrome;FMR1 gene;follow-up;Funding;Generations;Genes;Genetic Transcription;Genetically Engineered Mouse;Heart;Hour;Hybrids;Image;image translation;imaging system;Immediate-Early Genes;Individual;innovation;Investigation;Kinetics;Knock-in;Label;Learning;Location;long term memory;malignant neurologic neoplasms;Memory;Messenger RNA;Methodology;Microscopy;Modeling;Molecular;mRNA tagging;mRNA Translation;Mus;Nervous System Disorder;Neurons;novel;Outcome;Peptide Synthesis;Physiological;Play;Process;Production;protein activation;Protein Biosynthesis;Proteins;Reagent;real-time images;Regulation;Reporting;Resolution;response;RNA;RNA Editing;Role;Signal Transduction;Site;Slice;Spatial Distribution;spatiotemporal;Spottings;stem;Stimulus;Structural Protein;Synapses;synaptogenesis;Technology;temporal measurement;Time;Tissues;tool;Transgenic Animals;Translating;Translations;Travel;Visualization;Work

PROJECT_TITLE: Mechanism of mRNA Localization and Localized Translation in Neurons

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Heart Disease;Patient Safety

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The optimal approach to diuretic therapy in patients hospitalized for acute heart failure (AHF) remains poorly defined and contributes to prolonged inpatient stays, as well as unacceptably high death and readmission rates. We seek to evaluate a targeted diuretic approach guided by urinary sodium measurements, begun shortly after emergency department arrival, and protocolized throughout a patient’s hospitalization. We expect this will hasten and maximize symptom relief, decrease resource utilization and, regardless of results, have a significant impact on clinical care of patients with AHF.

PI_NAMEs: COLLINS, SEAN PATRICK (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Adverse event;Amiloride;analog;Blinded;Body Weight decreased;Cardiovascular system;Caring;Cessation of life;Clinical;clinical care;Clinical Trials;Consensus;Consumption;Data;design;Development;Diuretics;Dose;Dyspnea;Effectiveness;Emergency Department evaluation;Emergency Department patient;Enrollment;Ensure;epithelial Na+ channel;Excretory function;experience;Future;gamma ENaC;Guidelines;Heart failure;hospital readmission;Hospitalization;Hospitals;Hour;improved;improved outcome;individual response;inhibitor;Inpatients;Insulin;Intervention;Intravenous;Investigation;Length of Stay;Level of Evidence;Liquid substance;Measurement;Measures;Mediating;mortality;novel;Nurses;Outcome;Outpatients;Pathway interactions;Patient Care;Patients;Personal Satisfaction;personalized strategies;Precision therapeutics;prevent;primary outcome;pro-brain natriuretic peptide (1-76);Protocols documentation;Randomized;randomized trial;readmission rates;reduce symptoms;Residual state;Resistance;Resolution;Resources;response;Risk;Role;Route;secondary outcome;Slide;Sodium;Spottings;standard care;Standardization;Structure;success;symptomatic improvement;Testing;Therapeutic Trials;Time;Titrations;treatment arm;treatment as usual;Treatment Failure;treatment strategy;trial comparing;urinary;Urine;usual care arm;Visual;Work

PROJECT_TITLE: A Randomized Trial of Protocolized Diuretic Therapy Compared to Standard Care in Emergency Department Patients with Acute Heart Failure


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE There is a significant public health need for comprehensive lifestyle interventions to address health disparities related to low physical activity levels and unhealthy dietary quality among Latinas (cardiometabolic disease, obesity). Our study proposes a novel, low-cost and high reach web-based multiple-behavior intervention to increase physical activity and promote healthy eating in Latina women. This approach has potential to reduce the disproportionate burden of physical inactivity, poor diet quality and related chronic health conditions among the largest racial and ethnic minority group in the U.S.

PI_NAMEs: BENITEZ, TANYA J (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acculturation;Address;Adult;Affect;Area;arm;Behavior;behavior change;Behavior Therapy;Behavioral;bilingualism;Black race;Blood Pressure;Body fat;Body mass index;Body Weight;Cardiometabolic Disease;career;Child Care;Chronic;Chronic Disease;Clinical Trials;Communities;Consumption;Control Groups;cost;culturally appropriate intervention;Data;Development;Diabetes Mellitus;Diagnosis;Diet;Diet Habits;dietary;dietary guidelines;Dietary Intervention;disease disparity;disorder prevention;disparity reduction;ethnic minority population;Evaluation;evidence base;exercise intervention;Extended Family;Family;Focus Groups;Food Labeling;food preparation;Fright;fruits and vegetables;Future;Goals;good diet;Guidelines;handheld mobile device;Health;Health behavior;Health Benefit;health disparity;Healthy Eating;Heart Diseases;Hypertension;Immigration;Individual;Infrastructure;innovative technologies;Intake;Interdisciplinary Study;interest;Internet;Intervention;intervention mapping;Interview;Language;Latina;Latina Population;Latino;Latino Population;Learning;Life Style;lifestyle intervention;Linguistics;Link;Measures;member;Mentorship;Methodology;modifiable behavior;modifiable risk;novel;nutrition;Nutritional Study;Obesity;Online Systems;Outcome;Overweight;Participant;Physical activity;physical inactivity;Population;Populations at Risk;preference;Prevalence;prevent;Process;programs;Public Health;racial minority population;Randomized;Randomized, Controlled Trials;reading difficulties;Reporting;Research;Research Personnel;Resources;Risk Factors;Role;Scientist;skills;social;Social support;Spanish;Stroke;Structure;success;sugar;sweetened beverage;Technology;Testing;theories;Time;Training;Transportation;treatment arm;Unhealthy Diet;Waiting Lists;web platform;web site;web-based intervention;White Women;Woman;Work

PROJECT_TITLE: Promoting Physical Activity and Healthy Eating in Latinas via Interactive Web-Based Technology


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Microbiome;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hepatocellular carcinoma incidence has been increasing in the past several decades in the United States due to increasing prevalence of non-alcoholic fatty liver disease. It is unkown what determines the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma and other end-stage liver disease. The objective of the proposed study is to establish a longitudinal cohort study of patients with non-alcoholic fatty liver disease with advanced fibrosis in the United States and to prospectively evaluate the modifying role of immunune response factors, bile acids and gut bacteria for the progression of non-alcoholic fatty liver disease with advanced fibrosis to hepatocellular carcinoma and other liver complications. The findings of the proposed study will advance the preventive strategy against the development of hepatocellular carcinoma and end-stage liver disease in high- risk population.

PI_NAMEs: BEHARI, JAIDEEP ;YUAN, JIAN-MIN  (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Adult;Affect;Alcohols;Animal Model;Antigens;Bile Acids;Biological Factors;cancer type;Cessation of life;Characteristics;Cirrhosis;Clostridium;cytokine;Deoxycholic Acid;Development;Diabetes Mellitus;effective therapy;elastography;end stage liver disease;Enrollment;Ensure;Environmental Risk Factor;experimental study;Exposure to;Family;fatty liver disease;Fibrosis;follow-up;Genes;genotoxicity;Glucose;Glycoconjugates;Glycols;Goals;Growth and Development function;gut bacteria;gut dysbiosis;gut microbiota;Health;Hepatic;high risk;high risk population;Homeostasis;Human;Immune;Immune response;Immune Tolerance;Immunologic Surveillance;Immunomodulators;Incidence;Individual;Infection;Inflammation;Inflammatory;Interleukin-12;interleukin-23;Interleukins;Intestines;Klebsiella pneumoniae;Lipids;Liver;Liver diseases;Liver Fibrosis;liver injury;Liver neoplasms;liver transplantation;Longitudinal cohort study;Malignant Neoplasms;member;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;microbial;Mus;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Organ;Outcome;overexpression;Participant;Patient-Focused Outcomes;Patients;permissiveness;Physiological;Portal vein structure;Prevalence;Prevention strategy;Primary carcinoma of the liver cells;Property;prospective;Prospective cohort;Public Health;receptor;Research;response;Risk;Risk Factors;Role;Serum;Signaling Molecule;simple steatosis;T cell response;T-Lymphocyte;The Cancer Genome Atlas;Tissues;Toxic Environmental Substances;treatment strategy;Triglycerides;Tumor Promotion;tumor-immune system interactions;United States

PROJECT_TITLE: Novel Determinants for Progression of Non-Alcoholic Fatty Liver Disease to Hepatocellular Carcinoma and Other Health Outcomes

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Estrogen;Lung;Rare Diseases;Regenerative Medicine

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Chloropicrin (CP) and phosgene (PG) are widely available chemical threat agents, yet the mechanisms of in vivo acute toxicity and long-term pathophysiologic impacts are not well understood. To protect the public and devise interventions following exposure we need a better understanding of the inhalation dose relationship to biological response, biomarkers of exposure and understanding on long term sequelae. This research will address these critical data gaps for these two chemicals in a mouse model.

PI_NAMEs: VAN WINKLE, LAURA S (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;acute toxicity;Address;Affect;airway epithelium;Alveolus;Animal Model;Area;Aromatase;Atmosphere;Binding;Biological;Biological Markers;Bite;Blood;Cell Proliferation;Cell Survival;cell type;Cells;cellular targeting;Cessation of life;Chemical Actions;chemical threat;Chemicals;Cytochrome P450;Data;Dose;Drug Metabolic Detoxication;Elements;Environmental Exposure;Enzymes;Epithelial Cells;epithelial injury;Epithelium;Equilibrium;Estrogens;experimental study;Exposure to;Female;Gases;Glutathione S-Transferase;Histopathology;Immune;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Inhalation;Inhalation Exposure;Injury;injury and repair;Intervention;Irritants;long-term sequelae;LoxP-flanked allele;Lung;lung injury;lung repair;Macrophage;male;Measurement;Measures;Mediating;Medical;medical countermeasure;Metabolism;Mixed Function Oxygenases;Molecular;Monitor;mouse model;Mucous body substance;Mus;Naphthalene;neutrophil;Nose;Olfactory Epithelium;Outcome;Pathogenesis;Pattern;Phase;Phenotype;Phosgene;Poison;Positioning Attribute;Predisposition;Proteins;Pulmonary Edema;Rattus;repaired;Research;Resolution;respiratory;response;Rodent;Role;Science;Secretory Cell;secretory protein;Signal Transduction;Soil;Strawberries;Structure of parenchyma of lung;Sulfhydryl Compounds;Testing;Thick;Time;tissue repair;tissue-repair responses;Tissues;Toxic effect;Vascular Plant;ventilation;Wild Type Mouse;Xenobiotic Metabolism

PROJECT_TITLE: Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance/Project Narrative Alcohol consumption by adolescents and young adults continues to be a substantive public health concern in the U.S. The hippocampus, one of the most alcohol-sensitive brain regions, is crucial for both memory and affective functioning and we have shown a number of deficits in hippocampal function after adolescent alcohol exposure. This project will identify specific biological mechanisms underlying those effects and assess several treatments that may prevent or reverse those effects on brain and behavioral function.

PI_NAMEs: SWARTZWELDER, H SCOTT (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-Dimensional;Acetylation;adolescent alcohol effect;adolescent alcohol exposure;Adolescent and Young Adult;Adult;Affective;alcohol exposure;alcohol use disorder;Alcohols;Anxiety;anxiety-like behavior;Aricept;Astrocytes;ATAC-seq;Behavior;Behavioral;Binding Sites;Biological;Brain;Brain region;Cell Death;cell type;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Confocal Microscopy;CREB1 gene;Data;Dedications;Dendritic Spines;density;dentate gyrus;Development;donepezil;Dorsal;Ephrin-A3;Ephrins;Epigenetic Process;Equilibrium;experimental study;FMR1 gene;follow-up;Funding;Future;gabapentin;Gene Targeting;Genes;Goals;Grain;Hippocampal Formation;hippocampal subregions;Hippocampus;Histone Acetylation;histone methylation;Histones;Impairment;Inflammatory;inflammatory marker;inflammatory milieu;knock-down;Label;Lentivirus;Long-Term Effects;Measures;Mediation;Memory;Microinjections;Molecular;Morphology;mRNA Expression;Nerve Degeneration;neurogenesis;Neuroimmune;neuroinflammation;Neurons;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Process;protein activation;protein expression;Public Health;Quantitative Reverse Transcriptase PCR;reconstruction;Relapse;Reporting;response;Role;sex;Signal Transduction;Site;Specificity;stress reactivity;Structure;Synapses;synaptic function;synaptogenesis;Testing;therapy development;ultra high resolution;underage drinking;Vertebral column;Viral;Western Blotting

PROJECT_TITLE: 1/8 NADIA U01 Effects of Adolescent Alcohol Exposure on Hippocampal Function in Adulthood


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: NARRATIVE The growing availability of endophenotypic data in cohort studies of Alzheimer’s disease (AD) provides an exciting opportunity to further characterize the genetic architecture of this devastating disease. However, there is a pressing need to develop and apply advanced harmonization approaches to align AD-related endophenotypes across cohorts. The goal of this coordinated national initiative – the AD Sequencing Project Phenotype Harmonization Consortium, or “ADSP-PHC” - is to provide a centralized database of robust endophenotypes for large-scale genomic analyses that will accelerate the identification of novel targets for therapeutic intervention in AD.

PI_NAMEs: CUCCARO, MICHAEL L;HOHMAN, TIMOTHY J (contact);TOGA, ARTHUR W

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Address;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloidosis;Artificial Intelligence;Automobile Driving;Autopsy;Award;Big Data Methods;Biological;Biological Markers;Catalogs;central database;Cerebrovascular Disorders;Cerebrovascular Trauma;Clinical;Clinical Data;Cognitive;cognitive performance;cohort;Cohort Studies;Collaborations;Communities;Complex;Data;data access;data dissemination;data harmonization;data repository;Data Set;data storage site;dementia risk;Diffusion Magnetic Resonance Imaging;Disease;Documentation;Education;Educational workshop;endophenotype;Ensure;epidemiologic data;FAIR principles;Foundations;Future;Genes;Genetic;genetic architecture;Genome;Genomics;Goals;gray matter;Impaired cognition;in vivo;Individual;Infrastructure;Injury;Letters;Liquid substance;Machine Learning;Magnetic Resonance Imaging;Measures;Metadata;Mission;Modernization;Movement;multidisciplinary;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;Neuropsychology;new therapeutic target;novel;online tutorial;Participant;Pathologic;Pathway interactions;Phenotype;Positron-Emission Tomography;Procedures;Protocols documentation;Qualifying;Research;Research Personnel;resilience;Resources;response;Risk;Site;Statistical Methods;Symptoms;Therapeutic Intervention;therapeutic target;tool;Trans-Omics for Precision Medicine;United States National Institutes of Health;vascular contributions;vascular risk factor;web portal;Work

PROJECT_TITLE: Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Substantial evidence has suggested that vascular networks are critical in the pathogenesis of Alzheimer's disease (AD) and the change in cerebral blood flow is one of the earliest indicators of the disease. However, current studies in living human brain are limited to large vessels while leaving the microvasculature unexplored. This study proposes to establish a novel optical microscopy technique to map the comprehensive microvascular architecture network in human AD brains, which builds up the foundations to unravel the biophysical changes in brain function during the disease progression.

PI_NAMEs: WANG, HUI  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease therapy;Anatomy;Animal Model;Animals;Architecture;Arteries;arteriole;Atrophic;biophysical model;Biophysics;Blood capillaries;Blood flow;Blood Vessels;Brain;brain tissue;Cerebral Amyloid Angiopathy;Cerebral cortex;Cerebrovascular Circulation;Cerebrum;Characteristics;Clinical;Clinical Data;Clinical Trials;Complex;computer framework;Computer Models;Data;deep learning;Dementia;density;Diameter;digital pathology;Disease;Disease Progression;Early Intervention;Epidemiology;Exhibits;Fiber;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Geometry;Goals;gray matter;hemodynamics;Human;human disease;human tissue;Image;Imaging Techniques;Impaired cognition;Impairment;in vivo;Individual;insight;Knowledge;Label;Lead;Length;Light;Link;Magnetic Resonance Imaging;Maps;Measurable;Measurement;Measures;medial temporal lobe;Memory Loss;meter;Methods;Microscopic;Microscopy;Microvascular Dysfunction;Modeling;Morphology;morphometry;Multimodal Imaging;Mus;Myelin;network architecture;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;novel;Optical Coherence Tomography;optical imaging;Optics;Oxygen;oxygen transport;Pathogenesis;Pathologic;Pathology;Pathway interactions;Perfusion;Physiology;Play;Population;pre-clinical;Prefrontal Cortex;Property;reconstruction;Records;Reporting;Resolution;response;Role;Sampling;Senile Plaques;Severity of illness;Signal Transduction;simulation;Slice;Structure;Symptoms;targeted therapy trials;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thinking;Time;Tissues;tool;two photon microscopy;vascular contributions;Vascular Diseases;Veins;venule;white matter;Work

PROJECT_TITLE: Novel Volumetric Optical Microscopy to Unravel Cerebral Microvascular Architecture and the Role in Functional Neuroimaging in Human Alzheimer's Disease


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative There is a pressing need for new, scalable approaches to address patient heterogeneity in diseases such as ALS and identify patient-specific or broadly-effective therapeutics for multiple forms of ALS, particularly those with unknown genetic etiologies. The proposed study will combine ALS iPSC models with a novel platform we developed for cancer therapeutics that uses single cell transcriptomics to assess drug effects on 10-50 patient lines in one dish. We anticipate that this study will establish this new platform and address the critical barrier of patient heterogeneity in ALS drug discovery, evaluate 3 newly discovered therapeutic targets with novel mechanisms of action on a large cohort of patient lines, determine if this model system can predict efficacy in vivo, and identify new targets through a genome-wide screen on multiple patient lines.

PI_NAMEs: GOODARZI, HANI ;ICHIDA, JUSTIN KAWIKA (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;arm;Biological Models;causal variant;Cell Line;Cells;clinical predictors;Clinical Trials;cohort;Complex;computerized tools;CRISPR interference;Data;Disease;disease model;disease phenotype;disease-in-a-dish;drug discovery;Drug Targeting;effective therapy;efficacy evaluation;Genetic;Genetic Predisposition to Disease;genome wide screen;genome-wide;Heterogeneity;in vivo;Individual;individualized medicine;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;insight;Malignant Neoplasms;Maps;mirror neuron;Molecular;motor function improvement;Motor Neuron Disease;Motor Neurons;Mus;Mutation;Nerve Degeneration;neurodegenerative phenotype;new therapeutic target;novel;Outcome;Patient Participation;patient-level barriers;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase II Clinical Trials;Phenotype;Population;Population Study;Process;protein TDP-43;Research;resistance mechanism;Resolution;response;screening;single-cell RNA sequencing;Specificity;stem cell model;superoxide dismutase 1;Tauopathies;Testing;therapeutic target;Therapeutic Uses;therapeutically effective;transcriptomics;treatment response;Variant

PROJECT_TITLE: Leveraging natural phenotypic variations of heterogenous ALS populations-in-a-dish to enable scalable drug discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: LAGIER-TOURENNE WARD BLAINEY – NARRATIVE Disruption of the natural splicing process that stiches together different parts of a gene to form proteins necessary for healthy function has emerged as a key mechanism leading to neurodegeneration in amyotrophic lateral sclerosis (ALS) and dementia. In this effort, three labs will collaborate to apply new genomic technologies that make it feasible for the first time to comprehensively track the abnormal splicing events occurring in disease and to identify genetic modulators that correct this process and may represent new therapeutic targets.

PI_NAMEs: BLAINEY, PAUL CLARK;LAGIER-TOURENNE, CLOTILDE  (contact);WARD, MICHAEL EMMERSON

PROJECT_TERMS: Address;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Autopsy;axon regeneration;Biological;Biological Assay;Biology;Brain;Cell model;cell type;Cells;Cellular Assay;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;CRISPR screen;Custom;Data Set;Defect;Dementia;Disease;DNA Damage;Event;Exons;Fluorescent in Situ Hybridization;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;functional genomics;gain of function;Genes;Genetic;Genetic Screening;genome wide screen;genome-wide;Genomic approach;Genomics;in situ sequencing;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitory neuron;innovation;knock-down;Knowledge;Libraries;Link;loss of function;Maps;Methods;Microglia;Microscopy;Morphology;Motor Neurons;mRNA Precursor;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;Neurons;new therapeutic target;novel therapeutics;Nuclear;nucleocytoplasmic transport;Optics;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Process;Protein Isoforms;protein TDP-43;Proteins;Reaction;Research;Resources;Ribonuclease H;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;screening;Seminal;Skeletal Muscle;Spliced Genes;stem cell biology;Technology;Therapeutic;Therapeutically Targetable;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;ward;Work

PROJECT_TITLE: Targeting Dysregulated RNA Splicing in Neurodegenerative Diseases


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Radiation therapy delivered at ultra-high radiation dose rates, which are more than 100 times faster than traditional radiation therapy delivery methods, has been postulated to produce a FLASH effect of similar tumor responses but with less toxicity to healthy tissue. However, not all preclinical studies testing ultra-high dose rates have reported consistent FLASH effects and no optimization has yet been performed to maximize the normal tissue sparing after FLASH compared to conventional irradiation. Therefore, the proposed study will analyze the FLASH effect using different types of radiation modalities, optimize parameters for delivery, and more precisely measure tumor curability, enabling consistent translation of this method of radiation therapy delivery to the clinic.

PI_NAMEs: SCHUELER, EMIL  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Abdomen;Aftercare;beamline;Biological;Biological Assay;biological systems;Body System;Brain;Cancer cell line;Cancer Center;Cancer Patient;Clinic;Clinical;clinical translation;clinically relevant;Consensus;conventional dosing;Data;Dependence;Dose;Dose Rate;Electrons;Ensure;Environmental Risk Factor;Evaluation;expectation;Foundations;Fractionation;Frequencies;gastrointestinal;Gastrointestinal tract structure;Goals;Immune system;immune system function;improved;in vivo;Individual;Institution;inter-institutional;irradiation;Linear Energy Transfer;Lung;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Mission;Modality;Modeling;Mus;National Cancer Institute;Normal tissue morphology;Oxygen;Photons;Physiologic pulse;Play;pre-clinical;preclinical study;preservation;prevent;Primary Neoplasm;Probability;proton beam;Protons;Quality of life;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Reporting;Reproducibility;Resources;response;Role;Sampling;Schedule;side effect;Skin;stem;subcutaneous;Testing;Therapeutic Effect;Time;tissue injury;Tissues;Toxic effect;Translations;tumor;tumor growth;tumor microenvironment;Tumor Tissue;Universities;Width

PROJECT_TITLE: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevance

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Data Science;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Natural products (NPs) have been a prolific source of small molecule drugs, but their discovery is currently hindered by repeated rediscovery of the same or similar compounds. The goal of the proposed research is to leverage big-data analysis and thorough biosynthetic investigations to produce new NPs from hundreds of thousands of untapped microbial biosynthetic gene clusters and thus significantly increase the chemical diversity of NPs. In doing so, we aim to reinvigorate the field of NP-based drug discovery which is well aligned with the mission of the National Institute of General Medical Sciences by laying the foundation to discover novel drug leads to address new and rising public health needs.

PI_NAMEs: LI, JIE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Anabolism;Big Data;bioactive natural products;Biomedical Engineering;Chemicals;Collaborations;Competence;Data Analyses;Data Correlations;drug discovery;Engineering;Environment;Enzymatic Biochemistry;Family;Fatty Acids;FDA approved;Firmicutes;Flavoproteins;Fostering;Foundations;Future;Gene Cluster;Genetic;Genome;Goals;Hydroxylation;In Vitro;Informatics;Investigation;Libraries;Mediating;Methods;microbial;Microbial Genetics;Mining;Mission;National Institute of General Medical Sciences;Natural product discovery;Natural Product Drug;Natural Products;Nature;novel;novel therapeutics;Orphan;Pathway Analysis;Pathway interactions;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Postdoctoral Fellow;programs;Proteins;Public Health;Research;screening;small molecule;Source;structural biology;Sulfur;Terpenes;Time;Training;undergraduate student

PROJECT_TITLE: Accessing and Expanding Natural Products Chemical Diversity by Big-data Analysis and Biosynthetic Investigation


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE In this study we propose to contribute to the national ECHO Program by recruiting a diverse cohort of pregnant individuals from two medical centers at Kaiser Permanente Northern California serving a diverse population (~70% racial/ethnic minority groups with 50% having a low income), the conceiving partner, their resulting child, and to follow all of them at multiple visits after the child is born. Individuals who have a second pregnancy during the study period, the conceiving partner and child, will be recruited for a preconception pilot study. We will investigate the impact of maternal prenatal psychological distress, substance use, and lifestyle factors (diet and 24-hour movement) on child obesity and neurodevelopment and identify potential mechanisms and factors that may moderate adverse effects. Findings from this study will have important implications for informing interventions, prevention strategies and policies to ensure optimal health and well- being for all children.

PI_NAMEs: AVALOS, LYNDSAY AMMON;HEDDERSON, MONIQUE MARIE (contact);ZHU, YEYI

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: Address;Adverse effects;Affect;Anxiety;Birth;Blood;Body mass index;California;Cannabis;Censuses;Characteristics;Child;Child Health;Clinic Visits;Clinical Research;cohort;Conceptions;Data;Devices;Diet;Dietary Practices;Electronic cigarette;Ensure;ethnic minority population;evidence base;experience;Exposure to;Fetal Development;Functional disorder;good diet;Growth;Health;healthy weight;Hour;Human Milk;improved;indexing;Individual;Infant;Intervention;Joints;Learning;Life;Life Style;lifestyle factors;Link;Low income;Measures;Mediating;Medical center;member;Mental Depression;Metabolic;metabolomics;mother nutrition;Movement;Neighborhoods;neurodevelopment;Neurodevelopmental Disorder;Neurodevelopmental Impairment;novel;Obesity;obesity in children;offspring;Opioid;Outcome;participant retention;Pathway interactions;Personal Satisfaction;Phase;Physical activity;Pilot Projects;Policies;Population Heterogeneity;postnatal;Pregnancy;pregnant;prenatal;prenatal exposure;prenatal health;prevent;Prevention;Prevention strategy;Problem behavior;Program Development;programs;Protocols documentation;psychological distress;Quality Control;Race;racial minority population;recruit;Research;residential segregation;Risk Factors;Role;Sampling;Science;sex assigned;Sleep;Social Problems;social vulnerability;Stress;substance use;Time;Umbilical Cord Blood;Visit

PROJECT_TITLE: Preconception and Prenatal Health Impacting Factors and Child Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PHR: Project Narrative This project will undertake discovery of protein blood biomarkers for the early detection of ovarian cancer using serial plasma samples from the PLCO biorepository in ovarian cancer cases and controls. Combined with a new technology that measures ~1,500 proteins in a small biological sample, and statistical modeling of longitudinal results, this project will have an excellent chance of identifying biomarkers that rise over time in a substantial fraction of ovarian cancer cases while remaining stable in most controls. Early detection of ovarian cancer may decrease mortality from ovarian cancer due to the much greater survival when detected in early stages.

PI_NAMEs: SKATES, STEVEN J (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Acute-Phase Proteins;Age;Algorithms;arm;Behavior;biobank;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Blood Proteins;Blood specimen;blood-based biomarker;CA-125 Antigen;cancer biomarkers;cancer diagnosis;Cancer Etiology;candidate marker;Cell division;cohort;Consumption;Custom;Data;Detection;detection sensitivity;Diagnosis;Diagnostic;Disease;early detection biomarkers;Early Diagnosis;Early identification;Goals;Growth;High Risk Woman;Inflammation;Investigation;Light;longitudinal analysis;Longitudinal Studies;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Modeling;mortality;new technology;novel;Pattern;Performance;Persons;Pilot Projects;Plasma;Plasma Proteins;Probability;Process;programs;protein biomarkers;Proteins;Proteomics;Resources;response;Sampling;screening;Screening for Ovarian Cancer;Serum;Signal Transduction;Specificity;Statistical Models;Symptoms;Technology;Test Result;Testing;Time;tumor;two-dimensional;Validation;Variant;WFDC2 gene;Woman;Women's trial

PROJECT_TITLE: Proteomic Analyses of Serial Prediagnostic PLCO Serum in Cases and Controls to Identify Early Detection Ovarian Cancer Biomarkers Rising in a Substantial Fraction of Cases and Stable in Most Controls


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Preclinical imaging is a critical component in the evaluation of drugs and development of imaging strategies to diagnosis disease and assess/predict response to therapy. The proposal aims to develop a preclinical imaging informatics platform to harmonize the utility of preclinical imaging, enhance reproducibility and open science among cancer researchers to support research and discovery in cancer.

PI_NAMEs: MARCUS, DANIEL SCOTT;SHOGHI, KOORESH ISAAC (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Advisory Committees;Animal Experiments;animal imaging;Animal Model;Animals;anti-cancer research;Architecture;automated image analysis;automated segmentation;base;Big Data;Biology;cancer imaging;clinical imaging;Clinical Research;Clinical Trials;co-clinical trial;Collaborations;Collection;Complex;computational pipelines;Computer software;Data;Data Commons;data management;data mining;Data Set;data sharing;Databases;design;Detection;Development;disease diagnosis;Drug Evaluation;Environment;ex vivo imaging;experimental study;Genetically Engineered Mouse;handheld mobile device;High Performance Computing;Image;imaging informatics;in vivo;Industry;Informatics;Institution;instrument;Internet;Intervention;Laboratories;Malignant Neoplasms;mathematical analysis;mathematical model;member;Metadata;Modeling;multimodality;multiparametric imaging;multiscale data;Mus;novel;novel therapeutic intervention;open data;open source;Pathology;Patients;Pharmaceutical Preparations;Physiology;portability;Positron-Emission Tomography;pre-clinical;precision medicine;Precision Medicine Initiative;preclinical imaging;preclinical study;Prediction of Response to Therapy;Privatization;Procedures;Process;programs;Protocols documentation;public health relevance;radiomics;Reproducibility;Research;Research Personnel;Research Support;Resources;response biomarker;Running;serial imaging;Services;Site;software development;Technology;The Cancer Imaging Archive;Time;treatment response;tumor;Tumor Burden;tumor xenograft;Vertebral column;web interface

PROJECT_TITLE: Development of an Open-Source Preclinical Imaging Informatics Platform for Cancer Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stroke;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE An ECHO Pregnancy Cohort site in Charleston, South Carolina, will fill an important recruitment gap by enrolling a study population from South Carolina. Pregnancy and preconception studies of environmental exposures that extend through childhood are critically needed to understand gestational and early life exposures and their association with health and disease in children and adults. Our proposed aims are innovative because they address the impact of joint exposure to chemical and non-chemical stressors, potential rural-urban differences in sources of chemical exposure and resulting complex chemical mixtures, and the identification of critical windows of exposure to complex chemical mixtures.

PI_NAMEs: HUNT, KELLY J (contact);NEWMAN, ROGER B

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Adult;adult obesity;Affect;African;Age;Air;Animals;Argentina;Asian;Birth;Black Populations;Black race;burden of illness;cardiometabolic risk;cardiovascular risk factor;Characteristics;Chemical Exposure;Chemicals;Child;Child Development;Childhood;cohort;Conceptions;Country;Cuba;Death Rate;Deep South;Developing Countries;Development;dietary;Discipline of obstetrics;Disease;disease model;Disparity;early life exposure;Egypt;Enrollment;environmental chemical;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;environmental stressor;epidemiology study;ethnic disparity;ethnic diversity;ethnic identity;Ethnic Origin;experience;Exposure to;fetal;Fetal Development;Future;geographic disparity;Geography;Goals;Health;health disparity;Healthy People 2020;Heart Diseases;Hispanic;Hypertension;in utero;Individual;Infant Mortality;Intervention;intrauterine environment;Joints;Latinx;Lebanon;Life;Link;Live Birth;Maternal Mortality;Measures;Medicaid;Medical;meetings;Metabolic;Mexico;mortality;Mothers;North America;Not Hispanic or Latino;Obesity;obesity in children;obesity risk;obesity treatment;Obstetric Delivery;Occupations;offspring;Outcome;Pacific Islander;Participant;Perinatal Exposure;personal care products;Persons;poor health outcome;Population;Population Heterogeneity;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;pregnant;Premature Birth;prenatal;prenatal experience;prenatal exposure;prepregnancy obesity;programs;Protocols documentation;Race;racial discrimination;racial disparity;racial diversity;racial health disparity;Recording of previous events;recruit;Recurrence;Research;research study;Rest;Risk;Risk Factors;Rural;Rural Community;Rural Population;Site;Slave;social;social vulnerability;Soil;Source;South Carolina;Spanish;Stress;Stroke;Stroke Belt;stroke incidence;study population;Temperature;United States National Institutes of Health;Universities;urban area;Vulnerable Populations;Water;Water Supply

PROJECT_TITLE: A South Carolina ECHO Pregnancy Cohort


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Mouse models spanning different ages and sexes are routinely used to quantify anatomic, molecular, and pathologic changes in neurodegenerative diseases like Alzheimer’s Disease (AD), yet, the scientific community lacks sexually differentiated rodent brain atlases of different ages that are necessary to accurately study these attributes. By applying the most advanced technologies available, we will (1) generate publicly available, sexually dimorphic 3D hippocampal aging and AD brain atlases to be used as standard atlas templates for all aging and AD research and (2) we will comprehensively characterize morphological dystrophies, as well as connectional and synaptic disruptions, across aging and AD. Our team, with decades of experience in connectomics and brain atlasing, is sure to deliver standard hippocampal atlas templates for all neuroscience research and to determine sexually dimorphic anatomic regions vulnerable across age and AD progression.

PI_NAMEs: DONG, HONG-WEI  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Aging;aging brain;aging hippocampus;aging process;Alzheimer's Disease;Alzheimer's disease brain;Amyloid;Anatomy;Androgen Receptor;Atlases;Brain;BRAIN initiative;Catalogs;cell type;Communities;Data;data portal;Data Set;data visualization;Deterioration;Diffusion Magnetic Resonance Imaging;Disease Progression;Dorsal;Early Onset Alzheimer Disease;ESR1 gene;Etiology;experience;Female;gamma-Aminobutyric Acid;Genetic;Glutamates;hippocampal pyramidal neuron;Hippocampus;Image;Impaired cognition;Informatics;Interneurons;Label;Late Onset Alzheimer Disease;Light;male;Manuals;Maps;Methods;Microscopy;Molecular;molecular domain;Morphology;mouse model;multimodality;Mus;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;Neurosciences Research;normal aging;older adult;Online Systems;Pathogenesis;Pathologic;Pathology;prevent;reconstruction;Regional Anatomy;Research;resilience;Resolution;response;Rodent;Senile Plaques;sex;Sex Differences;Sex Differentiation;sexual dimorphism;Stains;superresolution imaging;Synapses;Synaptophysin;tau Proteins;Technology;tool;Tracer;Transgenic Mice;Translating;transmission process;virtual reality;Visualization;Work

PROJECT_TITLE: Sexual dimorphic cell type and connectivity atlases of the aging and AD mouse brains


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Nutrition;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Sjögren’s Disease (SjD, previously known as Sjögren’s syndrome) is a chronic autoimmune disease that causes significant morbidity and predominantly affects women. While previous research has demonstrated that vitamin D deficiency is a known risk factor for several autoimmune conditions, the role of vitamin D in SjD is understudied. The objective of this F31 fellowship application is to identify and characterize vitamin D binding sites that are associated with SjD susceptibility, onset, and severity.

PI_NAMEs: YILMAZ, DEFNE  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 25-hydroxyvitamin D;absorption;Affect;Affinity;Antibodies;Apoptosis;Autoimmune Diseases;Autoimmunity;Binding;Binding Sites;Biological;Biological Process;calcium metabolism;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;cell growth;cell type;ChIP-seq;Chronic;chronic autoimmune disease;Classification;Clinical;Clinical Data;Data;Data Set;Development;Dihydroxycholecalciferols;Disease;Ethnic Origin;Fellowship;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic risk factor;Genetic Transcription;Genetic Variation;Genome;genome wide association study;Genomic Segment;Goals;Immune;immune function;immunoregulation;improved;Individual;Ingestion;International;lymphoblastoid cell line;Lymphocyte;Malignant Neoplasms;Measures;Mediating;Mendelian randomization;Mental Depression;Methods;Morbidity - disease rate;Osteoporosis;Outcome;Pathogenesis;Phenotype;Predisposition;Proliferating;Publishing;Race;receptor binding;Registries;Regulation;Regulatory Pathway;Research;Risk;Risk Factors;Role;Serum;Severities;Sialadenitis;Single Nucleotide Polymorphism;Sjogren's Syndrome;Stains;Study of serum;Study Subject;System;Testing;United States;Variant;Vitamin D;Vitamin D Deficiency;Vitamin D3 Receptor;whole genome;Woman;Work

PROJECT_TITLE: Establishing the role of genetic variation in vitamin D-regulated gene expression in Sjogrens disease pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]