NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Hodgkin's Disease;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Survival rates for many childhood and adolescent cancers have improved at a remarkable pace over the past five decades. The Childhood Cancer Survivor Study (CCSS; U24 CA055727; PI: Armstrong) cohort has been the source of some of the most significant publications to date addressing the long-term mortality, morbidity and quality of life of survivors of childhood cancer. Understanding the risk for late effects of childhood cancer and its therapy provides the basis for health screening recommendations and interventions that can mitigate long-term health problems in this high-risk population.

PI_NAMEs: ARMSTRONG, GREGORY  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: 21 year old;Address;Adolescent;Baseline Surveys;biobank;Cancer Survivor;Case Report Form;chemotherapy;Child;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Clinical Treatment;Clinical Trials;Clinical Trials Cooperative Group;cohort;Consent;Data;Diagnosis;Disease susceptibility;DNA sequencing;Dose;Eligibility Determination;Enrollment;follow-up;Future;Genetic Predisposition to Disease;Genotype;Health;health related quality of life;high risk population;Hodgkin Disease;improved;Institution;Intervention;Investigation;Late Effects;Malignant Childhood Neoplasm;Malignant Neoplasms;Morbidity - disease rate;mortality;multidisciplinary;novel therapeutics;Outcome;Participant;Patient Recruitments;Patients;Pediatric Oncology Group;Principal Investigator;Protocols documentation;Publications;Quality of life;Recontacts;recruit;Relapse;Research;Research Personnel;Resources;Risk;screening guidelines;Site;SNP array;Source;Survival Rate;Survivors;survivorship

PROJECT_TITLE: Childhood Cancer Survivor Study/Children's Oncology Group Late Effects Assessment Protocol


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Physical Activity;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The novel research proposed here aims to understand, identify, and characterize the exercise-linked neural changes that may result in improved inhibitory control in schizophrenia spectrum disorders (SSDs). This research is crucial for justifying a longer-term exercise intervention to establish whether such benefits can be established over the longer term and paving the way for more focused research on potential therapeutic targets. Training of the applicant will potentially lead to next generation neuroimaging and computational psychiatry techniques that will dissect underlying neurophysiological and structural neuronal processes of brain function, behavior, and psychopathology among SSDs, with an emphasis on individual differences due to deafness.

PI_NAMEs: POPOV, VICTORIA ANNE (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Address;Adult;Aerobic Exercise;Age;Algorithms;analysis pipeline;Auditory Hallucination;base;Behavior;Behavioral;Brain;Characteristics;Chronic Disease;Clinic;Clinical;Clinical Trials;clinically relevant;Cognitive;cognitive control;Collaborations;Collection;Communication;Complex;Computer Models;Data;Data Collection;Databases;deaf;deafness;density;design;Development;Disease;diversity and inclusion;dosage;Early Intervention;Electroencephalography;Electrophysiology (science);empowerment;Environmental Risk Factor;Event-Related Potentials;Exercise;exercise intervention;Faculty;Freedom;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;functional outcomes;Generations;Goals;hard of hearing;Human;Image;imaging study;Imaging technology;improved;indexing;Individual;Individual Differences;Institution;Institutional Review Boards;Intervention;Knowledge;Lead;Learning;Linear Regressions;Link;Mentors;Methods;Modeling;multimodal neuroimaging;neural;neural circuit;Neuroanatomy;Neurocognition;neurocognitive disorder;neuroimaging;Neurons;neurophysiology;neuropsychiatric disorder;Neurosciences;next generation;novel;Paper;Participant;Performance;personalized diagnostics;personalized medicine;Persons;Pharmaceutical Preparations;Phase;Physical activity;Physical Exercise;Positioning Attribute;Postdoctoral Fellow;preclinical study;Process;Process Measure;programs;Psychiatry;Psychopathology;Psychophysiology;Psychoses;psychosocial outcome;Randomized;recruit;Research;Research Personnel;Research Project Grants;response;Risk;Role;Schizophrenia;schizophrenia risk;schizophrenia spectrum disorder;Sensory;Severities;sex;skills;Statistical Models;Stream;symptomatology;Symptoms;Task Performances;Technical Expertise;Techniques;Technology;Testing;therapeutic target;Training;treadmill;Universities;Variant;Visual Hallucination;Vocation;Walking;walking intervention

PROJECT_TITLE: An Acute Exercise Intervention to Ameliorate Behavioral and Neurophysiological Indices of Inhibitory Control Deficits in Schizophrenia: A Mobile Brain/Body Imaging (MoBI) Study

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discoveries to guide clinical translation, as well as develop and employ novel translational resources, models and technologies, to address the highly significant research and clinical challenge of Achilles tendinopathy. The Overall goal of the AT-CORT is to develop new insight and technologies that uncover the mechanobiologic basis of Achilles tendinopathy across length scales, from the nucleus, to the cell, to the tissue microenvironment to patients. Together, our highly interdisciplinary team, innovative tools, and interactive Research Projects and Cores will dramatically advance knowledge, develop innovative tools and insight, and provide new directions for translation of new therapies to treat Achilles tendinopathy.

PI_NAMEs: SOSLOWSKY, LOUIS J (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Address;Benchmarking;Biological Assay;Cell Nucleus;Cells;Center for Translational Science Activities;Chronic;Clinical;clinical predictors;clinical translation;Complement;Cytoskeleton;Data;Development;Disease;Drug Targeting;Environment;Enzymes;Exhibits;experimental study;Fostering;Goals;Gold;healing;Homeostasis;Human;Impairment;innovation;insight;Intervention;Knowledge;Length;Matrix Metalloproteinases;mechanical signal;Mechanics;Modeling;mouse model;Natural regeneration;next generation;novel;novel therapeutics;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pennsylvania;Phase;Physical therapy;Rattus;rehabilitation strategy;Rehabilitation therapy;Research;Research Project Grants;Resources;response;Signal Transduction;Technology;Tendinopathy;Tendon structure;Therapeutic;Tissues;tool;translational impact;Translations;transmission process;treatment strategy;Universities;Up-Regulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Headaches;Infectious Diseases;Lung;Migraine;Neurodegenerative;Neurosciences;Pain Research;Pneumonia;Pneumonia and Influenza

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Neurovascular unit dysfunction is seen in many neurological disorders, including post-pneumonia delirium and migraine. In this project, I will determine how bacterial pneumonia infection, specifically, if pneumonia-induced microglia activation first causes neurovascular unit dysfunction in vivo in experimental models, and differences in neurovascular unit state in pneumonia vs. non-pneumonia post-mortem human brain. For my postdoctoral project, I will utilize the methods I master during my PhD training to investigate the mechanisms of neurovascular dysfunction at the capillary level in migraine mouse models.

PI_NAMEs: CHANEY, SAMANTHA DAWN (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Age;Alzheimer's disease related dementia;Amaze;Astrocytes;Autopsy;Bacterial Pneumonia;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier permeabilization;Brain;brain tissue;Cephalic;Cerebrovascular Circulation;Chronic;Clinical;Cognition;cognitive function;COVID-19 pneumonia;cytotoxic;Data;Delirium;Dementia;Dendritic Spines;density;disability;disability-adjusted life years;Disease;Doctor of Philosophy;Dose;Drug Targeting;effective therapy;experience;Experimental Models;Functional disorder;glial activation;Gliosis;Goals;Headache;high risk;Hour;Human;imaging study;Impairment;in vivo;Induced Neurons;Infection;Injury;Intensive Care Units;Interview;intravital imaging;Label;learning strategy;Lung;Lung infections;Magnetic Resonance Imaging;Measures;Mentors;Methods;Microglia;Migraine;migraine treatment;Modeling;mouse model;multiphoton imaging;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;neurovascular;neurovascular unit;new therapeutic target;novel therapeutics;pathogen;Pathology;Pathway interactions;Patients;Persons;Phase;Pneumonia;Population;Positioning Attribute;Postdoctoral Fellow;Prevalence;Process;Pseudomonas aeruginosa;Quality of life;Regulation;Research;Research Personnel;Research Project Grants;Respiratory Tract Infections;serial imaging;skills;Structure of parenchyma of lung;Survivors;symposium;Synaptic plasticity;Syndrome;tau Proteins;tau-1;Techniques;temporal measurement;Testing;therapeutic target;timeline;Tissues;Training;transcriptome sequencing;vascular contributions;Wild Type Mouse;Work

PROJECT_TITLE: Pneumonia-induced microglial activation causes blood-brain barrier breakdown, astrocyte activation, and tau pathology


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The recent surge in misuse of prescription opioids as painkillers, such as oxycodone, and the easy accessibility to illegal opioids, such as heroin and fentanyl, have contributed to the current epidemic of opioid overdoses. Better treatments for opioid use disorder (OUD) are urgently needed to produce long-term recovery and avoid relapse of drug use in vulnerable individuals. However, our knowledge of how opioids affect different brain systems during disease progression is limited. This supplement is to support a project for a postdoctoral fellow to explore the role of glucocorticoid receptors in response to opioid use at a single cell level during different stages of disease progression in a rodent model of addiction.

PI_NAMEs: DE GUGLIELMO, GIORDANO ;TELESE, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Analgesics;Animal Model;Behavioral;Brain;brain cell;Brain region;Candidate Disease Gene;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;Data Set;Disease Progression;Drug Kinetics;drug relapse;Drug usage;Enhancers;Epigenetic Process;epigenome;Fentanyl;Funding;Gene Expression;Genes;Glucocorticoid Receptor;Grant;Heroin;Human;Individual;Intravenous;Knowledge;long term recovery;Maps;Mediating;Methodology;Modeling;multiple omics;neuroadaptation;Neuroanatomy;Opioid;opioid epidemic;opioid exposure;opioid overdose;opioid use;opioid use disorder;Oxycodone;parent grant;Parents;Postdoctoral Fellow;prescription opioid misuse;prescription pain reliever;Rattus;receptor binding;response;Rodent Model;Role;Self Administration;single cell genomics;System;Technology;Time;transcriptome;United States;Vulnerable Populations;XCL1 gene

PROJECT_TITLE: Multiomic profiling of cell types mediating opioid use disorder in rats


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Kidney Disease;Mental Health;Opioids;Pain Research;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The University of Florida Clinical Group (UF CG) is requesting a 12-month extension with funds to complete the ongoing IGNITE Network pragmatic clinical trials, GUARDD-US and ADOPT PGx. Additional time and funding are needed due to unanticipated network-wide delays in launching each trial and shutdowns due to COVID-19. Additionally, this administrative request includes leading analysis and publication costs for 13 secondary manuscripts.

PI_NAMEs: CAVALLARI, LARISA HUMMA (contact);JOHNSON, JULIE A.

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Acute;Acute Pain;Administrative Supplement;Adult;Adverse effects;African American population;African ancestry;anti-depressive agents;APOL1 gene;Biological;Blood Pressure;blood pressure control;Chronic Kidney Failure;chronic pain;Clinical;Clinical Trials;clinically relevant;comparison control;cost;COVID-19;Data;demographics;depressive symptoms;Disparity;Dose;economic impact;effective therapy;Effectiveness;Ethnic Origin;Florida;Funding;Future;genetic testing;genetic variant;Genomic medicine;Genomics;Genotype;Guidelines;Health;health care service utilization;health difference;health disparity;Healthcare;High Prevalence;high risk;Hypertension;hypertension control;hypertensive;improved;Kidney Failure;Knowledge;Manuscripts;Mental Depression;Opiate Addiction;Opioid;opioid therapy;Outcome;Pain;Pain management;Participant;participant enrollment;Patient Outcomes Assessments;patient population;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacogenomics;Pharmacotherapy;Pilot Projects;Population;Population Heterogeneity;Postoperative Pain;Pragmatic clinical trial;primary endpoint;primary outcome;prospective;Provider;Publications;Race;Randomized;recruit;Risk;risk minimization;Safety;secondary analysis;Selection for Treatments;Site;social determinants;Test Result;Testing;Time;treatment arm;treatment as usual;Universities;Vulnerable Populations

PROJECT_TITLE: IGNITE EP2 - Admin Supplement


ADMINISTERING_IC: DK

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Diabetes;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Over the past decade, indications for the use of metformin have steadily expanded to now include not only overt diabetes outside of pregnancy, but prediabetes, obesity, polycystic ovary syndrome, gestational diabetes (GDM), and type 2 diabetes during pregnancy. With its expanded use, however, questions of unintended long-term harm to offspring exposed to metformin during gestation have arisen. The current proposal will generate a Rhesus macaque model and robust data necessary and sufficient to understand if, what, whether and how early life exposure to metformin (with and without maternal & post-weaning Western style diet feeding) renders offspring persistently susceptible to obesity and insulin resistance.

PI_NAMEs: FRIEDMAN, JACOB E;KIEVIT, PAUL  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: 4 year old;Acceleration;Adolescent;American;Animal Feed;Animals;Automobile Driving;Biogenesis;Birth Weight;Clinical;clinical implementation;Clinical Research;Clinical Trials;cohort;Conceptions;Data;Development;Diabetes Mellitus;Diet;dietary control;early adolescence;early life exposure;Epidemic;Epidemiology;epigenomics;Event;experimental study;Exposure to;feeding;fetal;Future;Gestational Diabetes;Growth;High Fat Diet;Insulin Resistance;Islet Cell;juvenile animal;Lactation;Life;Liver;Low Birth Weight Infant;Macaca mulatta;Measures;Metabolic;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Metagenomics;Metformin;microbial;Mitochondria;Modeling;Molecular;mother nutrition;mRNA Translation;Muscle;Muscle Fibers;next generation;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Nutrient;Obesity;obesity development;offspring;Organ;Outcome;Pancreas;Pathway interactions;Perinatal;Pharmacodynamics;Phenotype;Physiological;Physiology;Placebos;Polycystic Ovary Syndrome;postnatal;Prediabetes syndrome;Predisposition;Pregnancy;prenatal exposure;prepregnancy;prevent;primary outcome;Primates;Puberty;Risk;secondary outcome;Series;Specimen;Testing;transcriptomics;Weaning;western diet;Woman

PROJECT_TITLE: Metformin in Pregnancy: Fetal Consequences & Long-term offspring Outcomes in a NHP model

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Neurosciences;Pain Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The Data Coordinating Center (DCC) of the EPPIC-Net, in close collaboration with the network’s Clinical Coordinating Center (CCC), the Specialized Clinical Centers (SCCs), HEAL, and government partners, will provide statistical and data management expertise for conducting high-quality efficient studies for developing non-addictive treatments for pain. In addition, it will compile a collection of clinical and biomarker data and establish a repository for biospecimens. These resources will be linked and shared with the community of pain researchers.

PI_NAMEs: TROXEL, ANDREA B (contact);YU, CHANG

PROGRAM_OFFICER_NAME: BARNES, JENNIFER HAMILTON

PROJECT_TERMS: Acute;advanced system;Algorithms;Architecture;Behavioral;Bioinformatics;Biological;Biological Markers;Biological Specimen Banks;biomarker discovery;Biometry;Cataloging;chronic pain;Clinic;Clinical;clinical center;clinical investigation;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Collection;Communities;complex data;Creativeness;dashboard;Data;Data Analyses;Data Collection;Data Coordinating Center;data dictionary;data ecosystem;data exchange;data harmonization;data integration;data management;Data Management Resources;data platform;data quality;data repository;Data Set;data sharing;data standards;Data Storage and Retrieval;Deposition;design;Development;Ensure;experience;FAIR principles;Fostering;Future;Genomics;Goals;Government;Growth;Helping to End Addiction Long-term;Human Resources;Image;improved;industry partner;Infrastructure;Institution;laboratory manuals;Leadership;Link;Maintenance;Manuscripts;Maps;Metadata;Methodology;Methods;microbiome;Monitor;neuroimaging;novel;Pain;Pain management;Pain Research;parent grant;Participant;Patients;Performance;Phase;Phase II Clinical Trials;Phenotype;pre-clinical;Preparation;Privacy;Procedures;Process;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Radiology Specialty;Randomized;Reporting;repository;Reproducibility;Research;Research Design;Research Personnel;Research Proposals;Resources;Retrieval;Risk;Running;sample collection;Sample Size;Sampling;Secure;sharing platform;Shipping;simulation;Site;Specimen;Standardization;Statistical Data Interpretation;Statistical Methods;statistics;Structure;System;Techniques;technology platform;Testing;Therapeutic;tool;Training;trend;user-friendly;web site;Work;working group

PROJECT_TITLE: EPPIC-NET DCC - Supplement


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SANTA CRUZ

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative The goal of this project is to develop an understanding of the detailed mechanisms by which clock proteins from diverse species generate circadian rhythms, used to align physiology and behavior with the day/night cycle for adaptive benefit. Bringing fundamental, molecular insight to the clock will facilitate the development of therapeutics that enhance the systemic synchronization of physiology and behavior to improve human health.

PI_NAMEs: PARTCH, CARRIE L (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Architecture;Behavior;Binding Sites;Biochemical;Biochemistry;Biological;Biological Clocks;biophysical techniques;Cellular biology;circadian;Circadian Rhythms;Clock protein;comparative;Complex;Cues;Cyanobacterium;enzyme activity;flexibility;Funding;Genetic;Goals;Health;Hour;Human;improved;insight;Intervention;Light;Link;Mammals;Molecular;National Institute of General Medical Sciences;pharmacologic;Physiology;Post-Translational Protein Processing;programs;Protein Dynamics;protein function;Proteins;Resources;Signal Transduction;structural biology;Structure;System;therapeutic development;Time

PROJECT_TITLE: Structures and mechanisms of circadian rhythms from cyanobacteria to humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Endolysosomal trafficking is a major cellular process that keeps aging neurons healthy by controlling whether cellular contents are properly recycled or degraded. Defective endolysosomal trafficking is a converging mechanism in neurodegenerative diseases including Huntington's disease, a fatal disorder caused by an autosomal-dominant mutation in the Huntingtin gene. The goal of this proposed study is to elucidate the precise mechanism and function of Huntingtin in endolysosomal trafficking in a physiologic organism to identify new molecular targets for treating Huntington’s disease.

PI_NAMEs: FARMER, STEPHEN M (contact)

PROJECT_TERMS: Advisory Committees;age related neurodegeneration;Aging;Alzheimer's Disease;autosomal dominant mutation;autosome;Binding;Biochemical;Biological Models;Biology;Brain;CAG repeat;Cell Physiology;Cells;Central Nervous System;Code;Complex;conditional knockout;Creativeness;Cultured Cells;Defect;Development;Disease;disease model;Drosophila genus;effective therapy;Endosomes;experience;fly;frontier;Functional disorder;gain of function;Genes;Genetic;Genetic study;Genomics;Goals;Homologous Gene;Human;Human Cell Line;human induced pluripotent stem cells;Huntington Disease;Huntington gene;In Vitro;in vivo;innovation;Integrins;Investigation;Knock-out;Knockout Mice;Knowledge;late endosome;Lead;Learning;Link;loss of function;Lysosomes;Mammalian Cell;Mediating;Mediator;Membrane;Mentors;misfolded protein;model organism;Modeling;Molecular;Molecular Target;Mus;Neurodegenerative Disorders;Neurons;neurotoxicity;new technology;normal aging;novel;Organism;Organoids;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phase;Phenocopy;Phenotype;Physiological;polyglutamine;Postdoctoral Fellow;Process;programs;recruit;Recycling;Regulation;Research;Research Personnel;Research Project Grants;Research Training;Resources;RNA interference screen;Role;skills;Societies;Structure;superresolution imaging;System;Testing;Therapeutic;therapeutic target;therapeutically effective;Thinking;trafficking;Training;translational potential;transmission process

PROJECT_TITLE: The role of Huntingtin in endolysosomal trafficking and Huntington's disease pathogenesis


NIH_SPENDING_CATS: Bioengineering;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative The human skeleton and its major joints, such as the hip and knee, arise developmentally as result of coordinated programs governing cartilage, connective tissue, and bone formation. The proposed research focuses on the role of individual cells in these complex developmental processes in the human hind limb, through the use of state-of-the-art technologies that will define the specific genetic processes cells utilize to give rise to functionally and morphologically distinct tissues and structures. Obtaining this molecular information is both timely and crucial to bridge the gaps in our knowledge of these important skeletal structures, and as such, a new resource will be made available to the scientific and medical communities to promote innovative solutions to orthopedic problems.

PI_NAMEs: CAPELLINI, TERENCE D (contact);CRAFT, APRIL MARIE

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Anatomy;Architecture;Behavior;Biology;Bone structure;Cartilage;cartilage cell;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Communities;Complex;Connective Tissue;Development;developmental disease;Developmental Process;Distal;Elements;Ensure;Event;Extracellular Matrix;Femur;functional genomics;Gene Expression;Genes;Genetic;Genetic Processes;Grant;Growth;Hip region structure;Histologic;Human;ilium;in utero;Individual;innovation;Investigation;ischium;Joints;Knee;Knee joint;Knowledge;Limb structure;Link;Locomotion;Mediating;Medical;Molecular;Morphology;multiple omics;Musculoskeletal;novel;Nucleic Acid Regulatory Sequences;Orthopedics;Osteogenesis;Pattern;Pelvis;Pharmacologic Substance;programs;Protocols documentation;Regenerative Medicine;regenerative therapy;Regulatory Element;Research;Research Personnel;Resolution;Resources;Role;single cell ATAC-seq;skeletal;skeletal disorder;Skeleton;spatial relationship;Structure;Technology;Therapeutic;Tissues;tool;transcriptomics

PROJECT_TITLE: Molecular architecture of the human knee joint and pelvis at single cell resolution

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Early cannabis use is associated with later use of harder drugs like opioids in humans, and rodent studies have suggested that THC may cause changes in opioid addiction-relevant brain circuits that could underlie this association. Microglia, the brains’ immune cells, contribute significantly to brain development by influencing neural circuit remodeling and rewiring, and they respond to developmental insults like THC as well as to adulthood opioid drugs. Here we study the causal roles of microglia in long-lasting pro-opioid effects, help uncover novel microglial biology with relevance to addiction, and attain training in RNA sequencing and bioinformatics, writing, and career development positioning me well for a career in addiction neuroimmunology.

PI_NAMEs: MARTINEZ, MARICELA XOCHIL (contact)

PROJECT_TERMS: Ablation;addiction;Adolescence;Adolescent;Adult;Anatomy;Animals;Area;Award;Behavior;Behavioral;behavioral economics;Behavioral Model;behavioral phenotyping;Bioinformatics;Biological;Biology;Brain;brain cell;Calcium;cannabinoid receptor;career;career development;Cells;Cognition;Communication;Community Outreach;Complex;conditioned place preference;critical developmental period;Data;Dedications;Development;disadvantaged background;Doctor of Philosophy;Drug Addiction;drug seeking behavior;Endocannabinoids;Environment;Epigenetic Process;Experimental Designs;Female;Funding;Gene Expression;Gene Expression Profiling;Genetic Transcription;Goals;Heroin;Human;Immune;improved;in vivo;in vivo imaging;Intervention;late life;Life;Link;male;marijuana use;Mentors;Mentorship;Microglia;Modeling;Modernization;Monitor;Motility;neural circuit;neurodevelopment;Neuroglia;Neuroimmune;neuroimmunology;Neurons;Neurosciences;next generation;novel;Opiate Addiction;Opioid;Outcome;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physical activity;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;preclinical study;Predisposition;Prefrontal Cortex;Process;professor;programs;Protocols documentation;Publishing;Rattus;remifentanil;Research;Research Personnel;Research Project Grants;response;Rewards;Risk;Rodent;Role;Scientist;sex;Signal Transduction;skills;Students;synaptic pruning;Techniques;tenure track;Testing;THC exposure;Tissue-Specific Gene Expression;tool;Training;transcriptome sequencing;Translating;Universities;Work;Writing

PROJECT_TITLE: Persistent Impacts of Adolescent THC on Microglial Function and Opioid Addiction Risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Utilizing advanced neuroimaging and machine learning to investigate subcortical arousal in auditory perception holds promise for improved detection of perceptual awareness, laying the groundwork for potential therapeutic interventions in severe brain disorders and anesthesia, when explicit reporting is challenging. Exploring non- invasive neuromodulation strategies for disorders of consciousness contributes to the development of novel therapeutic approaches, holding the potential to enhance health by offering a widely applicable intervention for patients with limited options for behavioral recovery following severe brain injuries.

PI_NAMEs: AERTS, SHANAE  (contact)

PROJECT_TERMS: Address;Anesthesia procedures;Animal Model;Area;Arousal;aspirate;Attention;Auditory;Auditory Perception;Awareness;Behavioral;Blinking;Brain;Brain Diseases;Brain Injuries;Brain Mapping;career;Cephalic;Classification;Clinical;Clinical Research;clinically significant;cohort;Coma;Complement;Conscious;Consciousness Disorders;cortex mapping;Data;Data Analyses;data quality;Deep Brain Stimulation;Detection;Development;Diagnosis;Diagnostic;end-of-life decision making;experience;Eye;Face;Focused Ultrasound;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Hallucinations;Health;Hearing Tests;Human Volunteers;improved;insight;Intensive Care;Intervention;Link;Machine Learning;machine learning model;Maps;Measurement;Measures;Methodology;Methods;Minimally Conscious States;Modality;Mydriasis;neural;neural network;Neuroanatomy;Neurobiology;neuroimaging;Neurons;neuroregulation;novel;novel therapeutic intervention;Operative Surgical Procedures;Output;Participant;patient population;patient subsets;Patients;Perception;Phase;Population;portability;Postdoctoral Fellow;Recovery;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Saccades;Safety;Seizures;Sensory;Signal Transduction;skills;Solid;Stimulus;Structure;success;Symptoms;Syndrome;Techniques;Technology;Testing;Thalamic structure;Therapeutic Intervention;Training;transcranial direct current stimulation;Translating;Traumatic Brain Injury;Visual;Visual Perception;visual tracking;Wakefulness;Work;Writing

PROJECT_TITLE: Mapping neural targets and advancing neuromodulation techniques for disorders of consciousness


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Data Science;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Understanding the impact of social determinants of health (SDoH) on the syndemic of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and substance use disorders is crucial for improving HCV and HIV screening and the timely connection of affected individuals to care. Using natural language processing, we propose developing a polysocial risk score based on SDoH and integrating it into a targeted prediction tool to assist clinicians identify at-risk individuals more effectively. This innovative tool will enhance our comprehension of the syndemic and contribute to achieving HCV and HIV elimination goals in the United States.

PI_NAMEs: PARK, HAESUK  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Affect;Algorithms;Award;career development;Caring;Characteristics;Clinical;co-infection;Collaborations;college;Comprehension;computer scientist;cooking;Data;doctoral student;Epidemiologist;Florida;Foundations;Goals;Grant;Health;Health Personnel;Health Policy;Health Services;Hepatitis C;Hepatitis C virus;HIV;HIV Infections;implementation strategy;improved;Individual;Infection;innovation;insight;Mentors;Methodology;Methods;Natural Language Processing;opioid epidemic;Outcome;parent grant;Performance;Pharmacologic Substance;Pharmacy facility;Policies;Policy Maker;predictive tools;Primary Care Physician;Principal Investigator;Research Personnel;Risk;risk prediction;Role;screening;skills;social health determinants;Substance Use Disorder;syndemic;tool;Training;transmission process;United States;Universities;unstructured clinical data;Vulnerable Populations;Writing

PROJECT_TITLE: Social determinants of health for predicting risks of HCV infection and HCV/HIV co-infection

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: OMAHA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Alzheimer’s disease (AD) is a pressing public health concern that defies simple prediction: 90% of AD cases are sporadic, reflecting the significant contributions of environment and lifestyle to AD risk. In this context, development is a critical time for foundational structural and functional brain maturation that can bias a person toward or away from AD risk later in life. This project will investigate the relationship between environment and relational memory to better understand the consequences of modifiable environmental risk factors for AD in early life (F99 phase) and across the lifespan (K00 phase).

PI_NAMEs: RAMIREZ, MEGHAN  (contact)

PROJECT_TERMS: 16 year old;Address;Adolescent;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;American;Award;biological age;Biological Aging;Biological Assay;Biological Markers;Birth Weight;Blood;Brain;brain abnormalities;Cause of Death;Child;Childhood;Cognition;cognitive ability;cognitive development;cognitive function;cognitive system;cognitive testing;Communication;critical developmental period;Data;deprivation;Development;Diagnosis;Disease;disorder risk;Early identification;Early Intervention;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epigenetic Process;Factor Analysis;familial Alzheimer disease;Foundations;Functional Magnetic Resonance Imaging;Genes;Genetic;Goals;grandparent;Health;Hippocampus;Hormonal;in utero;indexing;Individual;innovation;insight;Interdisciplinary Study;Intervention;Knowledge;Laboratory Research;large scale data;late life;Late Onset Alzheimer Disease;Lens Diseases;Life;life span;Life Style;Link;Machine Learning;Measurement;Measures;Memory;Mentors;modifiable risk;nanopore;Neighborhoods;Nerve Degeneration;neurodevelopment;neuroimaging;novel;parent project;Parents;Participant;Performance;Persons;Phase;Physical activity;Population;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;Pregnancy Complications;prenatal;programs;psychosocial;Psychosocial Factor;Psychosocial Stress;Puberty;Public Health;pyrosequencing;Questionnaires;recruit;relational memory;Reproducibility;Research;Research Personnel;Research Project Grants;resilience;Resources;Risk;Risk Factors;Scientist;Shapes;skills;social health determinants;Socioeconomic Status;statistics;Stress;System;Technical Expertise;Teratogens;Testing;Time;Training;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding the developmental impact of environmental risk factors on brain and cognitive systems vulnerable to Alzheimers disease in children


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Human neurological diseases associated with monoaminergic (e.g., serotonin, norepinephrine, dopamine) dysfunction affect millions of individuals worldwide; however, treatments for these neurodevelopmental, neurodegenerative and/or psychiatric disorders remain inadequate. Here, employing a truly unique combination of biochemical, molecular, and behavioral approaches, we are examining novel, neurotransmission independent roles for serotonin in brain in the direct regulation of neuronal gene expression. The experiments in this proposal will leverage cutting-edge technologies to understand how alterations in histone serotonylation (i.e., the covalent addition of serotonin to histone proteins) directly modulate neurodevelopmental and early life neural plasticity in a cell type specific manner.

PI_NAMEs: CUNNINGHAM, ASHLEY  (contact)

PROJECT_TERMS: Adolescence;Adult;Affect;Animal Behavior;Architecture;Attenuated;Behavior;Behavior Control;Behavioral;behavioral phenotyping;Binding;Biochemical;Bioinformatics;bioinformatics tool;Brain;career;Cell Nucleus;Cell Physiology;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;combinatorial;Computer Vision Systems;Coupled;covalent bond;critical period;Data;Data Analyses;Data Set;Development;Dominant-Negative Mutation;Dopamine;early life stress;Embryo;Environmental Impact;Epigenetic Process;epigenetic regulation;epigenomics;experimental study;extracellular;Female;Fiber;frontal lobe;Functional disorder;gene editing technology;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Glutamine;Goals;Histone H3;Histones;Homeostasis;Hormones;Human;In Vitro;in vivo;Individual;Laboratories;large scale data;Life;lifetime risk;Ligands;Link;Lysine;Machine Learning;machine learning method;male;Male Adolescents;Medial;Mediating;Mental Depression;Mental disorders;Mentors;Methylation;Modification;Molecular;Molecular Cloning;monoamine;Mood Disorders;mood regulation;multiple omics;Mus;Neonatal;nerve supply;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neuronal Plasticity;Neurons;neuropsychiatry;neurotransmission;Neurotransmitters;Norepinephrine;novel;oligodendrocyte progenitor;Oligodendroglia;Pattern;permissiveness;Phase;Photometry;Physiology;Play;Population;Post-Translational Protein Processing;Postdoctoral Fellow;postnatal;postnatal development;postnatal period;Precipitation;precursor cell;Prefrontal Cortex;Process;promoter;Proteins;receptor;Regulation;Research;Research Personnel;response;RNA;Role;Running;Scientist;Serotonin;sex;Sex Differences;skills;Sorting;Stimulus;Stress;stress reactivity;System;Techniques;Technology;Testing;Training;transcription factor;transcriptome sequencing;transcriptomics;vector;Viral;Viral Vector;Work

PROJECT_TITLE: Cell-type Specific Roles for H3 Serotonylation During Critical Periods of Postnatal Brain Development and Plasticity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The urgency to understand and treat disorders of cognition such as Alzheimer’s disease and Frontotemporal dementia continues to grow, yet we still don’t know the critical molecular events that underlie these diseases. During my dissertation work, I have developed an approach that has allowed me to identify the protein-binding partners of TDP43, a protein whose abnormal accumulation is found in many cognitive neurodegenerative diseases. In this proposal, I aim to use my discoveries to determine the mechanistic role TDP43 plays in synapses and why its function goes awry in disease.

PI_NAMEs: BREWER, ELIZABETH MORAN (contact)

PROJECT_TERMS: Adult;Affect;Age;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Automobile Driving;Back;beta catenin;Binding;Binding Proteins;Biology;Biotin;Biotinylation;Brain;causal variant;Cell Nucleus;Central Nervous System Diseases;Cognition;Cognition Disorders;Cognitive;Comprehension;Computer Models;Data;Dimerization;Disease;disease-causing mutation;DNA-Binding Proteins;Enzyme Interaction;Enzymes;Event;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Fructosediphosphate Aldolase;Functional disorder;Gene Expression;Generations;Genetic Transcription;Glucosephosphate Isomerase;Glycolysis;Goals;Grant;hexokinase;Hippocampus;Impaired cognition;improved;Induced Neurons;insight;Institution;Interphase Cell;Label;Lead;Ligase;Light;Link;Molecular;mouse model;multiple omics;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Output;Pathogenesis;Phase;Physical condensation;Play;Population;Post-Translational Protein Processing;Postdoctoral Fellow;Principal Investigator;Production;protein TDP-43;Proteins;Proteomics;Research Personnel;response;Ribosomal Interaction;RNA;RNA Processing;RNA Recognition Motif;RNA Splicing;RNA Transport;Role;scaffold;Scaffolding Protein;Seizures;Severities;Signal Transduction;Signaling Protein;Speed;Statistical Models;Synapses;synaptic function;Synaptosomes;Testing;Training;Transcript;Transcription Alteration;transcriptomics;Translations;Viral;Work

PROJECT_TITLE: Synaptic TDP43 in the Adult Mouse Brain


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Different regions of the skin vary in their characteristics such as thickness, pigmentation, innervation, and presence, size and density of hair follicles and sweat glands, that are reflected in differential responses to injury and to diseases such as androgenetic alopecia and psoriasis that predominate in specific skin regions. We propose to identify novel mechanisms that establish and maintain skin heterogeneity. Improved understanding of these mechanisms has potential to reveal new therapeutic targets for diseases that affect specific skin regions and have a major negative impact on quality of life; data obtained in this project will also inform strategies for generating specific skin types, including hair follicle- and sweat gland-bearing skin, for reparative skin grafting.

PI_NAMEs: MILLAR, SARAH E. (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Adult;Affect;Area;ATAC-seq;bisulfite sequencing;candidate identification;Cells;Characteristics;Chromatin;Cleavage Under Targets and Release Using Nuclease;Data;density;Dermal;Dermis;Development;differential expression;Disease;DNA Methylation;Dorsal;Embryo;Embryonic Development;Enhancers;Epigenetic Process;experimental study;Family member;Fetal Development;Genes;Genetic;Growth;Hair;hair erector muscle;Hair follicle structure;Heterogeneity;histone modification;Human;IGFBP4 gene;improved;in vivo;Insulin-Like Growth-Factor-Binding Proteins;Knockout Mice;Life;Maintenance;Male Pattern Baldness;Molecular;Mus;Muscle;Nerve;nerve supply;new therapeutic target;novel;parent grant;Pathway interactions;Pattern;Peripheral;Pigmentation physiologic function;Play;programs;Psoriasis;Quality of life;Repression;response to injury;Role;single cell ATAC-seq;single-cell RNA sequencing;Site;Skin;Skin graft;skin organogenesis;stem cells;Sweat Glands;Testing;Thick;tool;TWIST1 gene;wound healing

PROJECT_TITLE: Molecular mechanisms controlling skin heterogeneity

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Mosquito-borne diseases are a global concern that impact public health, tourism, and natural disaster recovery efforts. With no preventative vaccines or effective therapeutic option available for most mosquito-borne diseases, vector control efforts are the only combative option; however, these efforts are often limited by financial constraint and insecticide resistance concern. This proposed project aims to integrate cutting-edge mosquito collection traps, and novel remote sensing and machine learning workflows to guide local vector operations and direct abatement efforts in a cost-efficient manner.

PI_NAMEs: GUNTER, SARAH MURPHY;NOLAN, MELISSA SUZANNE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Abate;Aedes;Algorithms;Aptitude;arboviral disease;Arbovirus Infections;Arboviruses;Area;Artificial Intelligence;atmospheric sciences;Bite;Breeding;Budgets;Cessation of life;Characteristics;chikungunya;Chikungunya virus;Cities;Climate;climate change;Clinical;Collection;combat;Comparative Study;Competence;Complex;Compost;cost;cost efficient;Culicidae;Data;data standards;Decision Making;Dengue;Dengue Virus;Detection;Development;Discipline;Disease;Disease Outbreaks;Ecology;Economics;Environment;Environmental Health;Environmental Impact;Epidemic;Evaluation;Event;Eye;Food;Gases;Geography;Gravid;Growth;Habitats;Health;Health Benefit;high risk;Household;Human;Human Bites;Image Analysis;Imagery;Impairment;improved;indexing;Individual;Industry;Infrastructure;innovation;Insecticide Resistance;Insecticides;Intervention;Lasers;Life;Location;Machine Learning;machine learning model;Manuals;Maps;meteorological data;Methods;metropolitan;Microclimate;Mosquito Control;Mosquito-borne infectious disease;Natural Disasters;Neighborhoods;Neurologic;next generation;novel;Oils;operation;Outcome;pathogen;Pattern;Persons;Pilot Projects;Population;predictive modeling;predictive signature;preference;preservation;Prevention;Preventive vaccine;Process;programs;prospective;Protocols documentation;Public Health;rapid detection;Reaction;Recovery;remote sensing;Reproducibility;Resolution;Resources;Risk;Robotics;scientific atmosphere;Seasons;Security;Sentinel;Side;Site;Solid;Sorting;spectrograph;Surveillance Methods;System;Techniques;Technology;Testing;therapeutically effective;Time;tool;Toy;transmission process;United States National Aeronautics and Space Administration;vector;vector control;Visualization;wasting;Weather;weather patterns;ZIKA;Zika Virus

PROJECT_TITLE: Next generation mosquito control through technology-driven trap development and artificial intelligence guided detection of mosquito breeding habitats

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Alzheimer’s Disease is a currently incurable brain disease. Brain entropy is an important trait of brain function and may provide critical information for unveiling neuromechanisms of complex disorders like AD. Using large existing data, this project will examine brain entropy change in AD and to assess brain entropy as a potential biomarker for AD. Given our aging population and the increasing prevalence of AD, performing this project is likely to have significant public health impact.

PI_NAMEs: WANG, ZE  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Area;Biological Markers;Brain;Brain Diseases;Brain Injuries;Clinical;Cognition;Cognitive;cognitive control;cognitive function;cognitive reserve;Compensation;Complex;Consumption;Data;Data Set;deep learning;Dementia;Detection;Deterioration;disability;Disease;Disease Management;Education;Elderly;Entropy;experience;Failure;Functional Magnetic Resonance Imaging;functional outcomes;Future;glucose metabolism;Hippocampus;imaging biomarker;Impaired cognition;improved;Individual;Intervention;Knowledge;Language;Literature;machine learning method;Magnetic Resonance Imaging;Maps;Measurement;Measures;medial temporal lobe;Memory;men;method development;mild cognitive impairment;Modeling;neuroimaging;neuroimaging marker;neuromechanism;normal aging;Normal Range;novel;open source;Outcome;Pain;Pathology;Patients;Pattern;Persons;Positron-Emission Tomography;potential biomarker;predictive modeling;Prefrontal Cortex;Prevalence;public database;Public Health;Publishing;Reporting;Research;Research Personnel;Rest;Role;Severity of illness;sex;Shapes;support vector machine;Symptoms;tau Proteins;Testing;therapy development;tool;trait;translational study;uptake;Woman;Work

PROJECT_TITLE: Brain entropy mapping in Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Myotonic dystrophy (DM) is the most common cause of adult onset muscular dystrophy and the second most common cause of muscular dystrophy overall. The goal of this proposal is to determine the role of CELF1 upregulation in muscle pathogenesis in combination with MBNL loss of function.

PI_NAMEs: COOPER, THOMAS A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3' Untranslated Regions;Adult;Alleles;Alternative Splicing;autosome;CUG repeat;Disease;Fetal Proteins;gain of function;Genes;Genetic Transcription;Goals;Human;Knock-out;Link;loss of function;Messenger RNA;Molecular;mortality;mouse model;Mus;Muscle;Muscular Atrophy;Muscular Dystrophies;mutant;Myotonic Dystrophy;Myotonic dystrophy type 1;Nuclear;Nuclear RNA;Pathogenesis;postnatal development;Protein Isoforms;Proteins;response;RNA;RNA-Binding Proteins;Role;Skeletal Muscle;skeletal muscle weakness;Transgenic Mice;Up-Regulation

PROJECT_TITLE: Mechanisms of Skeletal Muscle Pathogenesis in Myotonic Dystrophy Type 1

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH This project introduces and investigates the scientific premise that age-related reductions in walking performance and economy have been mistakenly attributed solely to muscles spanning the ankle, and instead originate interdependently with unfavorable changes in the active, passive, and structural regulation of foot stiffness and power. Accordingly, the translational purpose of this proposal is to test the efficacy of shoe stiffness modifications to augment foot structure and function in aging and thereby improve gait performance and reduce metabolic energy cost during walking in older adults. Ultimately, this project addresses the need for new and modifiable targets to enhance mobility and independence – paving the way for feasible and cost-effective assistive devices for millions in our aging population.

PI_NAMEs: FRANZ, JASON R (contact);TAKAHASHI, KOTA

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;age related;Aging;aging population;Ankle;Biomechanics;career;career development;cost;cost effective;doctoral student;efficacy testing;Environment;Equilibrium;Fellowship;foot;Future;Gait;Human;improved;improved mobility;Institution;interest;Joints;Measures;Mechanics;Mentors;Metabolic;Modification;Movement;Muscle;Neuromechanics;North Carolina;older adult;parent grant;Performance;Public Health;Regulation;Research;Role;Self-Help Devices;Shoes;skills;Structure;Training;Translations;underrepresented minority student;Universities;Utah;Walking;walking performance;walking stability

PROJECT_TITLE: A framework for feasible translation to enhance foot and ankle function in aging and mobility

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Substance use disorder is a significant public health problem. Recent studies demonstrate that females are more vulnerable to the initiation, escalation and withdrawal effects of substance abuse behavior than males. This project will determine the effect of escape from X chromosome inactivation as an epigenetic mechanism on sex differences in addiction.

PI_NAMEs: OGHUMU, STEVE ONYEKA (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Address;Alleles;Animal Disease Models;Area;Award;Behavior;Bioinformatics;Biological;biomedical informatics;Biometry;Brain;Brain region;brain tissue;carcinogenesis;career;Cells;Chronic;Clinical;Clinical Research;design;Disease;Disparity;Drug usage;Epigenetic Process;experience;Exposure to;Female;Future;Gender;Gene Expression;Gene Modified;Gene Silencing;Genes;Genetic;Goals;Gonadal Steroid Hormones;Hormonal;Immunologic Factors;in vivo;Individual;inhibitor;innovation;Knowledge;knowledge base;Laboratories;Link;male;men;Methods;Modeling;Molecular;Monoamine Oxidase A;mouse development;mouse model;multidisciplinary;Mus;National Institute of Drug Abuse;Nervous System Disorder;Neuroglia;Neurons;Neurosciences;novel;novel marker;novel strategies;Opioid;Parents;Pharmaceutical Preparations;pharmacologic;pre-clinical;preclinical study;Process;programs;psychostimulant;Public Health;receptor;Reporter;Research;Research Personnel;Role;sex;Sex Chromosomes;Sex Differences;sex disparity;single-cell RNA sequencing;Substance abuse problem;Substance Use Disorder;substance use treatment;Talents;Technology;Tissues;tool;transcriptome sequencing;Visualization;Withdrawal;Woman;X Chromosome;X Inactivation

PROJECT_TITLE: X chromosome inactivation in sex disparities to substance use disorder


NIH_SPENDING_CATS: Cachexia;Cancer;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Narrative Skeletal muscle wasting during cancer cachexia has been long deemed to be a mere reflection of overall body degradation. Challenging this assumption, we generated a mouse model that phenocopied cancer cachexia from within the skeletal muscle by impairing ribosome biogenesis, the synthesis of new ribosomes, specifically in skeletal muscle. This proposal seeks to determine the etiology of cancer cachexia by interrogating this intrinsic mechanism in skeletal muscle that leads to muscle wasting and cachectic phenotype.

PI_NAMEs: FIGUEIREDO, VANDRE CASAGRANDE (contact)

PROJECT_TERMS: Ablation;Actins;Activin Receptor;Address;Adipose tissue;Adult;Advanced Malignant Neoplasm;Affect;Atrophic;Attention;Automobile Driving;Biogenesis;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Model;Cancer Patient;cancer survival;cellular targeting;chemotherapy;Clinical Research;Data;density;Down-Regulation;Enterobacteria phage P1 Cre recombinase;Etiology;experimental study;extend lifespan;Fiber;Gastrocnemius Muscle;GDF8 gene;Genetic Transcription;Health;Human;Hypertrophy;Impairment;improved;improved outcome;Injections;Investigation;Knock-out;Link;Long-Term Effects;LoxP-flanked allele;Maintenance;Messenger RNA;Metabolism;mortality;mouse model;Mouse Strains;Mus;Muscle;muscle form;muscle hypertrophy;Muscular Atrophy;novel;old mice;Outcome;Pharmaceutical Preparations;Phenocopy;Phenotype;Play;Process;Prognosis;promoter;Protein Biosynthesis;Quality of life;Regulation;respiratory;Reverse engineering;Ribosomal DNA;Ribosomes;Role;Seminal;Signal Transduction;skeletal;Skeletal Muscle;skeletal muscle wasting;Soleus Muscle;survivorship;Symptoms;Syndrome;Systemic disease;Tamoxifen;Testing;therapeutic target;Time;transcription factor;transcription factor UBF;transcriptome;tumor;Tumor Volume;Work

PROJECT_TITLE: Mechanisms driving muscle wasting and adipose tissue loss in the UBF mKO mouse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative This is a multidisciplinary, highly collaborative consortium that combines next--generation sequencing with state- -of-the-art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this consortium are to identify gene variants that are associated with compulsive-like cocaine intake and behavioral endophenotypes using genome--wide association studies (GWAS) in behaviorally characterized heterogeneous stock rats, and to strengthen the infrastructure of a newly created data/tissue repository (Cocaine Biobank) accessible to all researchers to study the cellular and molecular mechanisms related to cocaine use disorder. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of cocaine addiction-like behaviors in males and females, and increase the impact of a unique data/tissue repository that will facilitate follow--up and replication studies.

PI_NAMEs: GEORGE, OLIVIER  (contact);PALMER, ABRAHAM A

PROJECT_TERMS: addiction;Animal Genetics;Animal Model;Behavior;Behavioral;behavioral phenotyping;biobank;Biological;Brain;Chronic;Cocaine;Cocaine Dependence;cocaine self-administration;cocaine use;Cocaine use disorder;comorbidity;Complex;Data;deep neural network;endophenotype;Epigenetic Process;Female;follow-up;Gene Expression;Genetic;genetic analysis;genetic variant;genome sequencing;genome wide association study;genomic locus;Genomics;Goals;improved;Individual;Infrastructure;Intake;Intravenous;Lead;Machine Learning;male;Methodology;Modeling;Molecular;multidisciplinary;National Institute of Drug Abuse;new therapeutic target;next generation;next generation sequencing;novel;Nucleotides;Phenotype;Physiology;pre-clinical;programs;Rattus;Research Personnel;Resistance;Resources;Sample Size;screening;Self Administration;Substance Use Disorder;Tandem Repeat Sequences;Technology;Tissue Banks;transfer learning;United States National Institutes of Health;Variant;Video Recording

PROJECT_TITLE: Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein Rats


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: NARRATIVE The equipment from this project will enhance the NDSU VDL’s next-generation sequencing (NGS) capacity to support One Health and antimicrobial stewardship by implementing an easy to use, low-throughput digital microfluidics NGS library preparation system (MIRO CANVAS) that can be deployed outside the laboratory with a ‘portable’ sequencer and minimal equipment for pathogen detection, discovery, and identification. Due to the time and costs associated with NGS, it is not uncommon to save and batch samples for sequencing to justify the time and consumable costs; however, this is not ideal when timing is important for treatment of a sick animal or in the case of emerging pathogens or outbreaks. The walk-away use, low-throughput capacity, and portability make the MIRO CANVAS a very useful tool that will allow the NDSU VDL to quickly prepare and sequence pathogens of One Health importance such as Salmonella in addition to other pathogens and zoonoses that may also enhance antimicrobial stewardship through detection and monitoring of antimicrobial resistance genes.

PI_NAMEs: STENGER, BRIANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, MEGAN

PROJECT_TITLE: Building next-generation sequencing (NGS) capacity for One Health and antimicrobial stewardship projects An on-going case study of multidrug-resistant Salmonella in zoo mammals

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (02)]


ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

PHR: FDA CVM Vet-LIRN PROGRAM PROPOSAL  FOR FOA PAR-23-202 “FDA Vet-LIRN Network Capacity-Building Project and Equipment Grants” NARRATIVE This Veterinary Laboratory Investigation and Response Network (Vet-LIRN) capacity building project strengthens the capacity, collaboration, and integration of food-safety laboratories and networks, thereby facilitating an effective and coordinated response to future human and animal food safety issues. The Vet-LIRN at the U.S. Food and Drug Administration (FDA) and Animal Diseases Diagnostic Laboratory at the Ohio Department of Agriculture (Ohio ADDL) will collaborate to perform whole genome sequencing (WGS) of foodborne pathogen isolates. This project will support the identification and adoption of emerging technologies and the harmonization of analytical methods used by equipment platforms for antimicrobial resistance (AMR) studies.

PI_NAMEs: PRARAT, MELANIE  (contact)

PROJECT_TITLE: FDA Vet-LIRN Cooperative Agreement with Ohio ADDL to support projects and work associated with One Health, animal food issues, antimicrobial resistance, and surge capacity testing.


ORG_CITY: TUCSON

ORG_NAME: CRITICAL PATH INSTITUTE

ORG_STATE: AZ

PHR: NARRATIVE The FDA Scientific Conference Grant Program will allow Critical Path Institute (C-Path) to host the “C-Path Global Impact Conference,” an interdisciplinary conference that will capitalize on strong existing collaborations between C-Path and its diverse group of stakeholders, including regulatory agencies (FDA, EMA, PDMA), pharmaceutical industry, academic researchers, non-profit organizations, and patient groups. Topics will focus on the current and future impact of C-Path’s core competencies in data management/science, model informed drug development and analytics, clinical outcome assessments, and biomarkers and how they are applied towards the fields of pediatrics, neurology, and rare and orphan disease. Specific sessions (e.g., regenerative medicine, patient focused drug development (PFDD), and model informed drug development (MIDD) will explain how C-Path can facilitate collaborations in drug development – sharing ideas, expertise, resources, and data – to create drug development tools that can help ameliorate some of the challenges with advancing medical products for underserved populations.

PI_NAMEs: ROMERO, KLAUS  (contact)

PROGRAM_OFFICER_NAME: HAYNES, LESLIE L

PROJECT_TITLE: C-Path Global Impact Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CBER-T (02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE This research will quantify the extent to which certain characteristics of educational tools can increase veterinarians' intention to follow antimicrobial stewardship guidelines and their confidence in their own efficacy to do so. We will explore whether a short educational video on antimicrobial stewardship or a summary of evidence-based guidance with accompanying citations can impact veterinarians' opinions on prescribing antibiotics for canine acute diarrhea and define characteristics of antimicrobial use resources that veterinarians identify as effective in changing their intention to reduce antimicrobial prescribing for canine acute diarrhea. We will use the Theory of Planned Behavior to quantify the knowledge, attitude, subjective norm (perceived social pressure regarding guidelines), and perceived behavioral control (perceived ability to follow the guideline) related to prescribing metronidazole for dogs with a common medical condition (i.e., acute diarrhea).

PI_NAMEs: FREY, ERIN  (contact)

PROJECT_TITLE: Impact of Antimicrobial Stewardship Resources on Companion Animal Veterinarians' Intention and Capability to Prescribe Fewer Antimicrobial Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (01)]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Public Health Relevance Statement: Project Narrative The purpose of this proposal is to get support to purchase a ultra-fast automated nucleic acid extractor and a superfast real-time thermocycler to increase sample analyses for the FDA-Vet-LIRN in the event of an animal food related illnesses. This will provide enhanced capacity for FDA Vet-LIRN surveillance assignments and routine case investigation of food- borne illness in animals.

PI_NAMEs: WANG, LEYI  (contact)

PROJECT_TITLE: Acquisition of two superfast equipment for molecular testing in UI VDL


ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative The proposed Thiamine HPLC-FLD quantification method will fill a diagnostic gap in the laboratories of the FDA Vet-LIRN network by standardizing a method for accurate quantification of thiamine, thiamine pyrophosphate(diphosphate), and thiamine monophosphate in animal feeds, tissues, and blood. This standardized method will facilitate implementation at laboratories with HPLC-FLD testing abilities, improving the availability of monitoring pet feeds to provide early warnings for mis-formulations and create surge capacity in emergent cases that might require significant feed recalls. The extension of this method into tissues and blood will allow confirmation of thiamine deficiency in suspect cases, facilitating treatment of any affected animals and providing evidence for any necessary related feed recalls.

PI_NAMEs: SNEKVIK, KEVIN ROY (contact);SYKES, CHELSEA

PROJECT_TITLE: Validation of quantative method for thiamine detection in animal feed, tissue and plasma


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Testing for antimicrobial resistance in sick animals is needed to support the mission of FDA to protect public health. In 2017, FDA Vet-LIRN launched a surveillance initiative including whole genome sequencing as a key component for mitigating the lack of standardization in antibiotic susceptibility testing in their network. Sequencing methods are now standardized across six laboratories in the network, including at Cornell, and we are requesting support for these activities for the next five years.

PI_NAMEs: GOODMAN, LAURA BRUNENGRABER (contact)

PROJECT_TITLE: Genomic surveillance for antimicrobial resistance in animals


ORG_CITY: OAKDALE

ORG_NAME: EJH & ASSOCIATES, LLC

ORG_STATE: MN

PHR: Project Narrative EJH & Associates, LLC (dba Datastream Connexion) will continue to deploy a customized Laboratory services and Knowledge Management Portal utilizing the LABSuite, a GovCloud-based Software as a Service platform to optimize and improve the sharing of animal health and veterinary diagnostics information, laboratory capabilities, and research projects within the Vet-LIRN network. The methods utilized by the LABSuite tools will improve the capabilities and capacity of laboratories to investigate potential animal foodborne illness outbreaks or contamination events. This project will leverage the existing LABSuite platform, in particular the laboratory directory (Lab-DIR) and Proficiency Testing Results Capture system (PT Module) utilized by the Food Emergency Response Network (FERN) and the APHIS Laboratory Network portal, formerly called the National Animal Laboratory Network (NAHLN) portal.

PI_NAMEs: HOFFMAN, ERIC  (contact)

PROJECT_TITLE: Vet-LIRN Portal Continuation and Improvements


ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE If successful, this project will allow for the rapid detection of multiple botulinum toxin serotypes in feed and animal samples, leading to an early diagnosis of botulism. Botulinum toxins are the most powerful bacterial toxins and are also among the most toxic substances yet identified; they pose a serious threat to animals and humans. Botulism in food animals can expose humans to the toxins via consumption of contaminated products such as milk.

PI_NAMEs: POPPENGA, ROBERT HOWARD (contact)

PROJECT_TITLE: Validation of Endopep-MS for qualitative detection of BoNT/A, /C, /CD, /D, and /DC in animal specimens and feed.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Resident-to-resident aggression (RRA) is a prevalent issue in long-term care with severe health consequences to residents, many of whom suffer from Alzheimer's Disease and Related Dementias (ADRD) and are minority racial/ethnic backgrounds. We propose to comprehensively examine the role of race and ethnicity in RRA using already existing prospective prevalence data, in addition to collecting nursing home stakeholder input to improve understanding of the role of race/ethnicity in RRA to inform a novel staff education RRA intervention development. This proposal thus has the potential to reduce race/ethnicity-related RRA, strengthen workforce training by improving provider competency for resolving race and ethnicity-related aggression among residents, and benefit residents with ADRD from diverse racial/ethnic backgrounds who are at higher risk of RRA involvement due cognitive impairment related behavioral symptoms. The Project Narrative remains unchanged by this supplement.

PI_NAMEs: CHANG, E-SHIEN  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Administrator;Advocacy;Aggressive behavior;Alzheimer's disease related dementia;Automobile Driving;Award;Basic Science;Behavior Therapy;Behavioral Symptoms;career;career development;Caring;Certification;Characteristics;Cluster randomized trial;Cohort Studies;community setting;Competence;Conflict (Psychology);Data;Data Set;Dementia;design;Development;Discipline;Discipline of Nursing;Disinhibition;Education;Educational Intervention;efficacy evaluation;Elder Abuse;Elder abuse prevention;Equity;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Origin;evidence base;experience;feasibility testing;Feedback;Focus Groups;Funding;Goals;Health;health disparity;health equity;Health equity research;high risk;Human Resources;Impaired cognition;implementation science;improved;Individual;Injury;Intervention;intervention program;Knowledge;Lead;Leadership;Learning Module;Long-Term Care;maltreatment;Measurable;Mentors;Mentorship;Methods;mild cognitive impairment;Minority;Modeling;multilevel analysis;novel;Nursing Homes;Older Population;Pattern;pilot test;Play;Policy Making;Population;Positioning Attribute;Prevalence;prevent;Prevention;Prevention strategy;Productivity;programs;prospective;Prospective Studies;Provider;psychological distress;public health priorities;public health research;Race;racial diversity;racial health disparity;racial minority;racism;Research;Research Personnel;resilience factor;response;Risk;Role;Safety;Scientist;skills;social;social health determinants;Societies;Summary Reports;Surveys;Symptoms;System;Testing;therapy development;Time;Training;trend;United States National Institutes of Health;verbal;Violence;Work

PROJECT_TITLE: "Improving Health Equity in Long-Term Care Residents with Dementia: The Role of Race and Ethnicity in Resident-to-Resident Aggression"


PHR: Project Narrative We will develop a method using High Performance Liquid Chromatography and Mass Spectroscopy (LC-MS) to detect the important cyanotoxin, microcystin-LS and related congeners, in fish tissue, animal tissue, and other food, feed, and diagnostic samples to assure food safety and improve veterinary diagnostic investigation of cyanobacterial poisoning cases. The LC-MS method will be used to assess an ELISA test-kit based screening method that was developed by Dr. Todd Miller at the University of Wisconsin, Milwaukee, to quantitate microcystins in fish tissues. Once validated, these analytical methods will be made available to toxicology laboratories in the Vet-LIRN network as a tool for screening foods and feeds and for veterinary diagnostic investigations.

PI_NAMEs: BISCHOFF, KARYN  (contact)

PROJECT_TITLE: Development of analytical methods for detecting microcystins in fish tissue


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Everyday life relies on the flawless execution of motor skills that are acquired during development, yet much is left to be understood about how the motor system develops control of skilled behavior. This research proposal seeks to determine how the brain acquires highly precise patterns of activity to achieve high levels of robust motor function. Results from this proposal will engender new insights into the brain’s implementation of precise motor control, thereby representing a major step forward in our understanding of the nature of motor learning.

PI_NAMEs: PASCUAL, LEILA MAY  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acoustics;Adolescent;Adult;Age;analog;Anatomy;Animals;Architecture;Articulation;Behavior;behavior change;Behavior Control;behavior prediction;Behavioral;bird song;Birds;Brain;Brain region;cell type;Cerebellum;Code;Complex;Consultations;Data;Development;Educational process of instructing;Electronic Medical Records and Genomics Network;Electrophysiology (science);extracellular;Feedback;Finches;Force of Gravity;Forelimb;Genetic;Gestures;Goals;Gymnastics;improved;Individual;insight;kinematics;Learning;Learning Skill;Left;Life;Limb structure;male;Mathematics;Methods;millisecond;Modeling;Molecular;Motor;Motor Activity;motor behavior;motor control;Motor Cortex;motor learning;motor skill learning;Motor Skills;Mus;Muscle;Nature;Nervous System;network models;neural;neural network architecture;neural patterning;Neuroanatomy;Neurons;neurophysiology;neuroregulation;novel;Output;Pattern;Performance;Population;Process;programs;Research;Research Proposals;Shapes;Signal Transduction;skill acquisition;skills;sobriety;Songbirds;Speech;Stereotyping;System;temporal measurement;Testing;Time;tool;Training;tutoring;Undifferentiated;Variant;Vocabulary;vocalization

PROJECT_TITLE: Motor Skill Learning and the Development of Precise Neural Codes


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: OAK RIDGE

ORG_NAME: OAK RIDGE ASSOCIATED UNIVERSITIES

ORG_STATE: TN

PI_NAMEs: BURNETTE, JENNIFER ;DILLMAN, ALLISSA AMANDA;GIBSON, LAFRANCIS  (contact)

PROGRAM_OFFICER_NAME: KUKKE, SAHANA NALINI

PROJECT_TERMS: Achievement;Address;Area;Awareness;Bioinformatics;Biological;Biology;Biomedical Research;Budgets;career;cohort;Collaborations;Communication;Communities;Community Surveys;Complex;Data;Data Analytics;data complexity;Data Coordinating Center;data ecosystem;data resource;Data Science;Data Scientist;Data Set;data tools;design;Development;Discipline;Education and Outreach;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;FAIR principles;Feedback;flexibility;Fostering;Funding;Future;Goals;graduate student;informant;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;Internet;Interview;Learning;learning community;Medical;meetings;Mentors;Metadata;Modeling;multiple datasets;novel;online community;Outcome;Outcome Study;outreach;Pain;Participant;Population Heterogeneity;Process;Program Development;programs;Qualifying;recruit;Reporting;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Literature;Scientist;skills;Structure;Students;tool;Training;Training Activity;training opportunity;Training Programs;training project;translational applications;United States;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Fostering Meaningful Use of Common Fund Data

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT (01)]


ORG_CITY: ARLINGTON

ORG_NAME: NAT'L ASSOC/STATE DEPARTS/AGRICULTURE

ORG_STATE: VA

PHR: Public Health Relevance Statement The objective of NASDA’s 2024 Annual Meeting is to provide information on current and emerging feed and food safety issues impacting agriculture and to build consensus among the states on regulatory approaches to these issues. The plenary speakers will give state regulators an opportunity to hear a national perspective on feed and food safety, enhancing attendees’ exposure beyond the current events they are dealing with in their respective states. NASDA members and staff work with FDA programs and leadership to ensure that consumers have a safe feed and food supply; 45 NASDA member agencies have cooperative agreements to implement the Produce Safety Rule; 47 state departments of agriculture have feed control authority, and over half of them are performing preventive controls inspections under the Food Safety and Modernization Act (FSMA); approximately 20 state departments of agriculture have manufactured food authority and cooperate with FDA in the administration of these laws. NASDA has collaborated with FDA on major outbreak announcements. Many NASDA member agencies also cooperate with FDA on food safety for milk and seafood. NASDA staff frequently posts FDA press releases in the weekly NASDA News e- newsletter and many NASDA members’ agencies link to FDA’s recall lists. NASDA staff also serve on the Executive Committee of the Produce Safety Alliance.

PI_NAMEs: GARRISON WARFEL, BECKY  (contact)

PROGRAM_OFFICER_NAME: HEAD, DANIELLE

PROJECT_TITLE: 2024 NASDA Annual Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (06)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative The U.S. is in the midst of a psychostimulant epidemic. Drug-craving is a diagnostic criterion of Psychostimulant Use Disorder for which there exists no clinically effective intervention. This project examines augmented calcium/calmodulin-dependent kinase II (CaMKII) signaling within the prefrontal cortex as a core neuropathology driving drug-craving.

PI_NAMEs: HUERTA SANCHEZ, LAURA  (contact)

PROJECT_TERMS: Abstinence;addiction;aged;American;AMPA Receptors;Animal Model;Automobile Driving;Award;behavioral health;Biochemical;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calmodulin;career;Chronic;Clinical;Cocaine;cocaine craving;cocaine seeking;cocaine self-administration;Cocaine use disorder;Cocaine withdrawal;Control Groups;craving;Cues;Cytology;design;diagnostic criteria;Disease;disease model;Dose;drug craving;Drug Exposure;drug relapse;drug reward;drug seeking behavior;Educational process of instructing;effective intervention;Environment;Epidemic;Exhibits;experimental study;Female;Fiber;FRAP1 gene;Future Teacher;Genetic;Glutamate Receptor;Glutamates;Goals;Histology;Human;Hyperactivity;Incubated;indexing;Individual;inhibitor;Institution;Job Application;Laboratory Study;Learning;Learning Skill;Link;male;Medial;Memory;Mentors;Mentorship;Metabolic;Microinjections;Modeling;Motivation;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural circuit;Neurobiology;neurochemistry;neuropathology;Neurosciences;optogenetics;Outcome;Permeability;Pharmaceutical Preparations;Phase;Phosphotransferases;Photometry;physical conditioning;PIK3CG gene;Positioning Attribute;Postdoctoral Fellow;Prefrontal Cortex;Procedures;psychostimulant;Publishing;Rattus;receptor;Receptor Inhibition;Receptor Signaling;Recovery;reinforcer;Relapse;Reporting;Research;Research Personnel;Research Project Grants;Research Technics;Role;Side;Signal Pathway;Signal Transduction;skills;Specificity;stimulant use disorder;Substance Use Disorder;Sucrose;Synaptic plasticity;Techniques;Testing;theories;Time;Training;Western Blotting;Withdrawal;Work

PROJECT_TITLE: Role of PL CaMKII in incubated cocaine-craving


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Type I interferons (IFN-Is) are important in infection and inflammation. The purpose of this study is to delineate the regulation of the IFN-I response by ISG15 and USP18. Improvements in our understanding of the regulation of IFN-I-mediated immune responses by ISG15 and USP18 will guide the design of both anti-inflammatory and anti-infectious therapeutic agents.

PI_NAMEs: BOGUNOVIC, DUSAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 2019-nCoV;Affect;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral resistance;Anti-viral Response;antiviral immunity;Astrocytes;Autoimmune;Autoimmune Diseases;autoinflammatory;autoinflammatory diseases;autosome;Blood Cells;calcification;Cell Line;Cell Nucleus;cell type;Cells;Child;Clinical;Collection;Complex;cytokine;design;Development;Disease;DNA Viruses;Down-Regulation;Exposure to;Functional disorder;gene product;Generations;Genes;Genetic;Goals;Growth;Health;HIV;Human;human induced pluripotent stem cells;Immune response;Immunologics;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Influenza A virus;Influenza B Virus;Interferon Type I;Interferons;ISG15 gene;Laboratories;Lymphoid Tissue;Measures;Mediating;Microglia;Molecular;mutant;nerve stem cell;Nervous System Disorder;Neurologic;Neurologic Symptoms;Neurons;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phagocytosis;Phosphorylation;Predisposition;preservation;Production;Property;Proteins;Proteome;pseudotoxoplasmosis syndrome;receptor;Regulation;Resistance;response;RNA;RNA Viruses;Role;Sendai virus;Signal Transduction;Simplexvirus;Specificity;Spondyloenchondrodysplasia;Synaptosomes;Testing;Therapeutic Agents;Tissue Model;Tissues;Transcription Initiation;transcriptome sequencing;Type I Interferonopathy;Ubiquitin;Up-Regulation;USP18 deficiency;Vesicular stomatitis Indiana virus;Viral;viral resistance;Virus;Virus Diseases;Zika Virus

PROJECT_TITLE: Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Ionotropic synapses are the specialized cell junctions that allow for chemical signals to be transmitted throughout the central nervous system; aberrations to synapse formation and development are defining features of numerous neuropsychiatric and neurodevelopmental conditions. This proposal aims to uncover the specific molecular mechanism by which the synaptic adhesion G-protein coupled receptor (aGPCR) Brain- specific angiogenesis inhibitor 2 (BAI2) facilitates synaptogenesis and synapse maturation across postnatal and adult development. Identifying and characterizing this molecular mechanism furthers our knowledge of synaptic development and may inform future pharmaceutical developments of aGPCR-mediated drugs.

PI_NAMEs: MEYER, CHRISTINA  (contact)

PROJECT_TERMS: Address;Adhesions;Adhesives;Adult;Affect;Angiogenesis Inhibitors;autism spectrum disorder;BAI1 gene;BAI2 gene;BAI3 gene;Bipolar Disorder;Brain;C-terminal;Cells;Central Nervous System;Chemicals;Clinical;Coculture Techniques;Cognition Disorders;Complex;confocal imaging;Data;Deletion Mutation;Dendritic Spines;density;Development;Disease;Dissociation;Dyes;Excitatory Synapse;exome;experimental study;F-Actin;falls;Family;fluorophore;Future;G-Protein-Coupled Receptors;gain of function mutation;Glutamate Receptor;Glutamates;Goals;Hippocampus;Human;human data;Hyperactive behavior;Individual;information processing;Intercellular Junctions;interest;Intrabody;Kinetics;Knowledge;loss of function mutation;malformation;Mediating;member;Mentors;Molecular;molecular pathology;Morphology;motor disorder;multidisciplinary;Mus;nano;Nanostructures;Nerve Degeneration;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neuropsychiatry;neurotransmitter release;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Play;Point Mutation;Positioning Attribute;Postdoctoral Fellow;postnatal;postsynaptic;presynaptic;Presynaptic Terminals;Protein Family;Proteins;Psychiatric therapeutic procedure;Publishing;receptor;Recycling;Research;Role;Schizophrenia;Signal Transduction;Slice;Spastic Paraparesis;Structure;Subgroup;superresolution microscopy;Synapses;Synaptic Vesicles;synaptogenesis;Time;transmission process;Vertebral column;vesicular release;Work

PROJECT_TITLE: The role of Brain-specific angiogenesis inhibitor 2 (BAI2) in synaptic structural organization and functional dynamics


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Relevance to Public Health Due to its significant involvement in biological processes, chemotaxis contributes to disease progression in cancer and arthritis, while its impairment leads to anomalous tissue development or regeneration. Our unique molecular actuators that can exert “physical force” specifically onto intended intracellular objects, can be a tool for not only dissecting the molecular mechanisms of chemotaxis, but also interfering with these cell migration-related diseases.

PI_NAMEs: INOUE, TAKANARI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;angiogenesis;Arthritis;Back;Biochemical Reaction;Biological Process;Cell membrane;cell motility;Characteristics;Chemotactic Factors;Chemotaxis;Cytoskeleton;Development;Disease;Disease Progression;Embryonic Development;Event;Exhibits;Feedback;Filopodia;Goals;Impairment;Link;Logic;loss of function;Malignant Neoplasms;Mechanics;Membrane;Molecular;molecular actuator;Monomeric GTP-Binding Proteins;Morphology;Natural regeneration;Neoplasm Metastasis;Nuclear Envelope;operation;Pathologic;Phase;Phenotype;Physical condensation;physical property;Physiological;PIK3CG gene;polarized cell;Property;Proteins;Public Health;Receptor Protein-Tyrosine Kinases;rho GTP-Binding Proteins;Series;Signal Transduction;spatiotemporal;Techniques;Tissues;tool;transcription factor;wound healing

PROJECT_TITLE: Decoding dynamic interplay between signaling and membranes in chemotaxis by molecular actuators

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN

PROJECT_TERMS: Address;Advisory Committees;Articulation;Bioinformatics;Biomedical Research;built environment;Businesses;career;Centers of Research Excellence;Charge;Climate;cloud based;Collaborations;Committee Members;Communication;Communities;community college;conflict resolution;Curiosities;Degree Completion;Degree program;Development;Diverse Workforce;doctoral student;Education;education research;education resources;Educational Curriculum;Educational process of instructing;Eligibility Determination;Ensure;Environment;Evaluation;experience;Face;Faculty;faculty mentor;faculty research;formative assessment;Fostering;Funding;Goals;Grant;Health;higher education;Idaho;improved;Individual;Industrialization;Industry;Influentials;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;International;Internships;Knowledge;Leadership;Learning Module;Link;Medical Education;Medical Students;member;Mentors;Modification;Monitor;Montana;multidisciplinary;New Mexico;Outcome;Persons;Positioning Attribute;Postdoctoral Fellow;Process;Program Research Project Grants;programs;Qualifying;recruit;Rejuvenation;Research;Research Activity;research facility;Research Infrastructure;Research Personnel;Research Support;Resources;Rural;Science;science education;Science, Technology, Engineering and Mathematics Education;Scientist;Series;Signal Transduction;skills;Structure;student training;Students;success;symposium;System;Talents;Teacher Professional Development;Training;Training and Education;undergraduate research;undergraduate student;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Idaho INBRE Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PI_NAMEs: LUSETTI, SHELLEY  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Achievement;Award;base;Biomedical Research;career;career development;Centers of Research Excellence;Cloud Computing;cohort;college;Communication;Communities;community based research;community college;Complement;computing resources;Consultations;Core Facility;Data Science;Data Science Core;Development;economic disparity;Educational Status;Educational workshop;Environment;Equipment;Evaluation;evidence base;experience;Faculty;faculty mentor;faculty research;faculty support;Fostering;Funding;Funding Opportunities;genome resource;Government;Grant;Health;Health Sciences;higher education;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Life Style;Measures;Medicine;Mentors;Mentorship;Mexican;Mining;Minority;Minority-Serving Institution;New Mexico;operation;organizational structure;Outcome;Population;Principal Investigator;Process;Productivity;Program Evaluation;Program Research Project Grants;programs;Publications;Reduce health disparities;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Role;rural area;Services;student participation;student training;Students;success;summer research;symposium;Technology;Training;tribal community;undergraduate student;Universities

PROJECT_TITLE: NM-INBRE Administrative Core


PHR: NARMS Project Narrative EJH & Associates, LLC (Datastream Connexion) propose to deploy and customize a Laboratory services and Knowledge Management Portal utilizing the LABSuite, a GovCloud-based Software as a Service platform to optimize and improve the sharing of animal health, veterinary diagnostics, human health and retail food information, laboratory capabilities, along with research projects within the NARMS network. The methods utilized by the LABSuite tools will improve the capabilities and capacity of laboratories to investigate potential animal foodborne illness outbreaks or contamination events. This project in its first phase will leverage the existing LABSuite platform, in particular the laboratory directory (Lab-DIR) and Proficiency Testing Results Capture system (PT Module) utilized by the Food Emergency Response Network (FERN), the APHIS Laboratory Network portal, formerly called the National Animal Laboratory Network (NAHLN) portal, and Vet-LIRN.

PROGRAM_OFFICER_NAME: KABERA, CLAUDINE

PROJECT_TITLE: NARMS Laboratory Portal


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Disability Research;Infectious Diseases;Nutrition;Physical Activity;Women's Health Research

PHR: Tiredness, weakness, and disability occur more frequently in older people living with HIV than in  non-infected people of a similar age. The reasons are not known. These studies will investigate  whether the ability of muscles to metabolize nutrients to generate energy is impaired and  contributes to the increased weakness and physical decline in older people living with HIV.

PI_NAMEs: WEISS, ROBERT G (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;Attenuated;Bioenergetics;Biological Markers;Biopsy;Body Composition;Body mass index;Clinical Research;cohort;Data;design;disability;Dual-Energy X-Ray Absorptiometry;effective therapy;Elderly;Energy Metabolism;Exercise;exercise intolerance;Exercise Test;Exercise Tolerance;experience;Fatigue;Fatty acid glycerol esters;Frail Elderly;frailty;functional decline;Functional disorder;Future;Gait;Gait speed;Gender;General Population;HIV;HIV Infections;Human;human old age (65+);immune activation;Impairment;in vivo;Individual;Inflammation;inorganic phosphate;insight;Intervention;Life;Lipids;Lower Extremity;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;men;Metabolic;metabolic myopathies;Metabolism;middle age;Mitochondria;Mitochondrial DNA;Mobility disability;Morbidity - disease rate;mortality;Muscle;Muscle Mitochondria;Muscular Dystrophies;Myopathy;novel;Nutrient;older men;Older Population;older women;patient population;Performance;Persons;Phenotype;Population;pre-clinical;premature;Preparation;Quality of life;Race;Rest;Role;sex;skeletal;Skeletal Muscle;Stress;Syndrome;Testing;United States National Institutes of Health;Walking;Woman

PROJECT_TITLE: Mitochondrial energetics, exercise intolerance and fatigability in older people with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: No PHR

PI_NAMEs: AVILLACH, PAUL ;BEECH, BETTINA M.;BORRAYO, EVELINN ;BURGE, LEGAND L.;CARLISLE, ALEX JAMES;CASILLAS, ALEJANDRA ;JONES, HARLAN PIERRE;JUAREZ, PAUL D;MALIN, BRADLEY A.;MANSON, SPERO MARTIN;NORRIS, KEITH C;PURO, JON ;SAMBAMOORTHI, USHA ;SHANKER, ANIL ;SYED, TOUFEEQ AHMED;TAYLOR, HERMAN ALFRED;THORPE, ROLAND J.;VISHWANATHA, JAMBOOR K. (contact)

PROGRAM_OFFICER_NAME: GEBREAB, SAMSON YIKEALO

PROJECT_TITLE: AIM-AHEAD Coordinating Center - All Four Cores