NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Hematopoietic stem cell genome editing has the potential to cure hematologic disorders including hemoglobinopathies. Two major limitations to these advancements are the ability to consistently reach persisting therapeutic threshold of editing post-transplantation and the use of toxic, high-intensity conditioning that poses considerable risks to the treated patients. In this application, we propose a novel in vivo selection strategy for edited HSCs using base editors that will provide the foundation for safer and more effective HSC gene therapy protocols for hemoglobinopathies and other genetic diseases.

PI_NAMEs: KIEM, HANS-PETER  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adult;Alleles;Allogenic;Animals;Autologous;Autologous Transplantation;Autopsy;base;base editing;base editor;beta Thalassemia;Biological Assay;CD34 gene;Cell Transplantation;Cells;clinical translation;clinically relevant;conditioning;CRISPR/Cas technology;Data;design;Disease;DNA Double Strand Break;Dose;Drug resistance;efficacy evaluation;Engineering;Engraftment;Enzymes;experimental study;fetal;Fetal Hemoglobin;Foundations;gamma Globin;gene correction;Gene Modified;gene replacement therapy;Generations;Genes;Genetic Diseases;genome editing;genotoxicity;Globin;graft vs host disease;Guide RNA;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin concentration result;Hemoglobin F Disease;Hemoglobinopathies;Human;Human Cell Line;Immunodeficient Mouse;In Vitro;in vivo;innovation;Macaca mulatta;Measures;Mendelian disorder;Messenger RNA;MGMT gene;Modeling;Modification;Monitor;multidisciplinary;Mus;Mutation;nonhuman primate;Normal Cell;novel;Other Genetics;Patients;Pharmaceutical Preparations;Phenotype;post-transplant;prime editing;prime editor;Production;protein purification;Protocols documentation;Reagent;Regimen;Research;research clinical testing;Research Personnel;resistance mutation;Risk;RNA Sequences;Safety;safety assessment;Sickle Cell;Sickle Cell Anemia;sickling;side effect;Source;stem cell biology;stem cell gene therapy;System;Testing;Therapeutic;therapeutic gene;Time;Titrations;tool;Toxic effect;transplant model;Transplantation;Treatment Efficacy;Viral;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Multiplex base/prime editors for in vivo selection of modified HSPCs in hemoglobinopathy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE: African Caribbeans have a high burden of diabetes, muscle fat infiltration and muscle weakness, which may lead to higher levels of age-related physical limitations and disability; however, there is currently no comprehensive information from individuals in this geographic region on muscle and physical performance. Therefore, this study seeks to directly measure skeletal muscle mass, and comprehensively phenotype physical performance in a large, established cohort of African Caribbean men and women living on the island of Tobago. This information can be used in future efforts to better prevent age-related declines in muscle and physical performance – an enormous public health issue – which will greatly enhance the quality of life of older adults in this region.

PI_NAMEs: MILJKOVIC, IVA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Admixture;Adult;Aerobic;Africa;African;African American population;African ancestry;African Caribbean;Age;age related;age related decline;age-related muscle loss;aged;Aging;Biological Assay;Black race;Body Composition;Body fat;Body measure procedure;Caribbean region;Caucasians;Clinical;cohort;Connective Tissue;Creatine;Data;design;Diabetes Mellitus;disability;Disablement;Dual-Energy X-Ray Absorptiometry;Elderly;epidemiology study;European;European ancestry;Exercise;Exercise Tolerance;Family;Fatty acid glycerol esters;Foundations;Funding;Future;Genetic;Geographic Locations;Habits;Health;Health Care Costs;Healthcare;high risk population;Hypertension;Immigrant;Impairment;improved;Individual;Infiltration;Institutionalization;Insulin Resistance;interest;Investigation;Island;Life Style;Longevity;Measures;Medical History;men;Metabolism;Methods;mortality;Muscle;muscle form;muscle strength;Muscle Weakness;Muscular Atrophy;novel;Obesity;older adult;Out-Migrations;Outcome;oxidation;Participant;Pathway interactions;Patient Self-Report;Pattern;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Population;Population Research;Predisposition;Premature Mortality;prevent;Prevention;protective factors;Public Health;Quality of life;recruit;reduced muscle mass;reduced muscle strength;Research;retention rate;Risk Factors;Skeletal Muscle;standard measure;Testing;Thinness;Time;Tobago;United States National Institutes of Health;Walking;Water;Woman

PROJECT_TITLE: The Study of Muscle and Physical Performance in African Caribbeans.

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Drusen are the hallmark feature of early age-related macular degeneration (AMD), but their pathogenesis remains elusive due to the lack of good animal models. Nonhuman primates (NHP) are the only mammals to possess a true macula similar to humans and spontaneously develop soft drusen with lipid accumulation resembling human AMD. This study will establish an NHP model of soft drusen with detailed ophthalmic, metabolic, and genetic characterization, determine the impact of high-fat/sugar (HFS) diet and atorvastatin on drusen progression, and explore the gene expression of macular retinal pigment epithelial cells in eyes with and without drusen, HFS diet, and statins.

PI_NAMEs: YIU, GLENN  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age;Age related macular degeneration;aged;Animal Model;animal old age;Animals;Apolipoprotein E;Apolipoproteins;Apolipoproteins B;Arterial Fatty Streak;atorvastatin;Binding;Bioinformatics;Blindness;Body fat;Body Weight;Body Weights and Measures;California;Cardiovascular Diseases;Cells;Cholesterol;Cholesterol Esters;Choroid;cohort;Complement;Complement Membrane Attack Complex;Contralateral;cost;Deposition;Development;Diet;dietary;Dietary Fats;Dose;Drusen;Elderly;Epidemiology;Euthanasia;Evolution;Exposure to;Eye;Fasting;Fatty acid glycerol esters;Fundus;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genome sequencing;Glial Fibrillary Acidic Protein;Goals;Growth;Health;hepatic lipase;Heterogeneity;High Density Lipoproteins;High Fat Diet;Histologic;Human;Hydroxymethylglutaryl-CoA Reductase Inhibitors;Image;imaging capabilities;Imaging technology;Immune;Immunohistochemistry;in vivo;in vivo imaging;Inflammatory Response;insight;Intervention;Laboratory Animals;lipid metabolism;Lipids;Lipofuscin;lipoprotein lipase;Lipoproteins;Low-Density Lipoproteins;Macaca;Macaca mulatta;macroglia;Macrophage Activation;macula;Mammals;Measures;Metabolic;Modeling;Molecular;mRNA Expression;Multimodal Imaging;multimodality;National Institute on Aging;new therapeutic target;next generation sequencing;nonhuman primate;novel therapeutics;Oils;ophthalmic examination;Optical Coherence Tomography;Oral;oxidation;Pathogenesis;Pathway interactions;Patients;Phenotype;Pilot Projects;Placebos;Plasma;Prevalence;Primates;programs;recruit;Research;Resolution;Retina;Risk Factors;Role;serial imaging;Serum;sex;Simvastatin;single-cell RNA sequencing;Smoking;Structure of retinal pigment epithelium;sugar;Surveys;Susceptibility Gene;Testing;therapy development;Tissues;Transferase;translational study;Triglycerides;whole genome

PROJECT_TITLE: Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degeneration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Gut dysbiosis and dysregulated immune responses have been implicated in the pathogenesis of inflammatory bowel disease. Metabolites produced by gut microbiota are critical for shaping the host innate immune functions required for controlling intestinal inflammation. These studies seek to uncover the molecular mode of action that governs the innate immune sensing of gut microbial metabolites and promotes intestinal health.

PI_NAMEs: IP, W. K. EDDIE  (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: Anti-Inflammatory Agents;Bile Acids;Carrier Proteins;cell growth regulation;Cell membrane;Cells;Chronic;Colon;cytokine;Data;Defect;Development;Exhibits;Genes;Goals;gut bacteria;gut dysbiosis;gut inflammation;gut microbiota;Health;Homeostasis;Immune response;immunoregulation;Immunosuppression;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innate immune function;innate immune sensing;insight;interest;Intestines;Knowledge;Large Intestine;Macrophage;Mediating;Metabolic Control;Metabolism;microbial;Molecular;Molecular Target;novel;Organic Anion Transporters;Outcome;overexpression;Pathogenesis;Pathway interactions;Phenotype;Prevention;Public Health;receptor;Research;Role;Shapes;Small Intestines;Tissues;uptake;Volatile Fatty Acids

PROJECT_TITLE: Role of SLCO3A1 in macrophage metabolite sensing and IBD

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The Inflammatory Bowel Diseases (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), are diseases of the gastrointestinal tract that result from abnormal immune response to luminal antigens in genetically-susceptible individuals. IBD represents a disease of major interest, with nearly 3 million American afflicted with this chronic inflammatory disorder. The proposed studies are designed to identify and harness information from novel, inflammation-related metabolic pathways that promote tissue healing. Such studies should provide new avenues into our understanding of why inflammatory diseases develop, and in particular, how innate immune responses contribute to inflammatory resolution.

PI_NAMEs: COLGAN, SEAN P (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acidity;Acidosis;Acids;Acute;Adenosine;American;Animal Model;Anti-Inflammatory Agents;Antigens;base;Bicarbonates;Buffers;Cells;Chronic;Colitis;Crohn's disease;Cullin 2 Protein;Data;design;diadenosine triphosphate;Digestive System Disorders;Disease;Disease Progression;enhancing factor;Enzymes;Epithelium;Escherichia coli;experimental study;extracellular;Funding;G-Protein-Coupled Receptors;Gastrointestinal Diseases;Generations;Goals;gut inflammation;healing;Homeostasis;Human;Hypoxia;Hypoxia Inducible Factor;Ileitis;Immune response;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;innovation;insight;interest;intestinal epithelium;knock-down;Mediating;Metabolic;Metabolic Pathway;Metabolism;migration;Modeling;Molecular;mouse model;Mucositis;Mucous Membrane;Mus;Natural Immunity;neutrophil;new therapeutic target;novel;nucleotide analog;Nucleotides;olfactory receptor;overexpression;Patients;Permeability;pH Homeostasis;Phase;Physiological;Predisposition;Publishing;Receptor Signaling;Recruitment Activity;Regulation;Resolution;response;Role;Signal Transduction;Site;SLC26A3 gene;Source;Surface;System;Testing;therapeutic target;Tissues;Transcript;Transgenic Mice;Ulcerative Colitis;Work

PROJECT_TITLE: Mechanisms of Adenosine Protection

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project will study unique CD8 T cells that have the potential to confer cross-protection against different virus variants and immunity against persistent immune evasive viral infection. Understanding the requirements for the generation of these CD8 T cells, characterizing their phenotype and function, and creating new tools to track them during an immune response to infection is important to expand our immune armament against viruses. Our studies will inform the design of much needed universal vaccines against existing and emerging viruses, and guide new therapies for chronic viral infections.

PI_NAMEs: BLANDER, JULIE MAGARIAN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Animals;Antigen Presentation;Antigen Presentation Pathway;antigenic peptide transporter;Antigens;CD8-Positive T-Lymphocytes;Cell membrane;Cell surface;Cells;Chronic;chronic infection;Clinical;Complex;Cowpox virus;cross immunity;Cross Presentation;Cross-Priming;Cytoplasm;cytotoxic CD8 T cells;Dendritic Cells;design;Development;draining lymph node;emerging virus;Endoplasmic Reticulum;Endosomes;Epithelial Cells;Epitopes;Etiology;falls;Family member;Functional disorder;Generations;Golgi Apparatus;Health;Hematopoietic;Herpesviridae;Histocompatibility Antigens Class I;Human;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunological Models;Impairment;Infection;Location;Lung;Major Histocompatibility Complex;Mass Spectrum Analysis;Mediating;Membrane;Memory;Modeling;Monitor;multicatalytic endopeptidase complex;Mus;Mutation;novel;novel therapeutics;novel vaccines;Pathway interactions;peptide based vaccine;Peptides;Phenotype;Poxviridae;Process;Publishing;Recrudescences;Recycling;Residual state;response;Role;Site;Smallpox;SNAP receptor;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;TAP1 gene;TAP2 gene;Testing;Therapeutic;Tissues;Toll-like receptors;tool;universal vaccine;unpublished works;Vaccine Design;Variant;Variola minor;Viral;Viral Antigens;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Mobilizing TAP-independent CD8 T cells through non-canonical cross-presentation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: HERSHEY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: HCMV is a ubiquitous virus found throughout all geographic regions and socioeconomic groups that has severe clinical implications when infection occurs in immunocompromised individuals and pregnant women. This project seeks to elucidate the molecular details of two HCMV maturation steps, acquisition of tegument proteins and secondary envelopment. These studies focus on the contribution of two viral proteins, UL88 and UL71. These studies will provide both important information regarding the viral life cycle and elucidate potentially novel ways in which viral replication can be targeted therapeutically.

PI_NAMEs: NORBURY, CHRISTOPHER C (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;aging population;Anti-viral Agents;antiviral drug development;Biological Assay;Capsid;Cell Nucleus;Clinical;clinically relevant;Complex;Cytomegalovirus;Cytoplasm;Data;Disease;DNA biosynthesis;DNA Packaging;Early Endosome;Endosomes;Event;experimental study;Fluorescence;Geographic Locations;Human;Image;Immunocompromised Host;improved;Individual;Infection;insight;interest;Intervention;Investigation;Knowledge;Learning;Life Cycle Stages;Link;Mass Spectrum Analysis;Mediating;Membrane;Molecular;Molecular Motors;Neck;Newborn Infant;novel;novel therapeutic intervention;Organelles;Predisposition;Pregnant Women;Process;Protein Analysis;Proteins;Publishing;resistance mutation;Role;screening;Site;socioeconomics;Structural Models;targeted treatment;Therapeutic;Therapeutic immunosuppression;trafficking;Viral;viral fitness;Viral Proteins;Virion;Virus;Virus Assembly;Virus Replication;Work

PROJECT_TITLE: Analysis of the mechanism of HCMV cytoplasmic envelopment

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative There are a dearth of opportunities for students from underrepresented backgrounds to obtain specialized post-baccalaureate training in neuroscience, though such training is becoming increasingly important for admission to top neuroscience PhD programs. Here, we propose further development of PiNBAC, a post- baccalaureate program launched in 2021 with significant mentorship, research and educational components housed in the Harvard Medical School Department of Neurobiology, and affiliated with the T32-funded Harvard PhD Program in Neuroscience. Early program outcomes suggest that PiNBAC is an effective approach to train a diverse neuroscience workforce by preparing talented trainees from underrepresented groups for successful application to, and success within, competitive PhD programs to continue their training.

PI_NAMEs: ASSAD, JOHN  (contact);DATTA, SANDEEP R;TAN, TARALYN MARIE

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academic skills;Academic support;Address;Admission activity;Advisory Committees;Area;Awareness;Brain;Career Choice;Data;Data Analyses;Development;Disparity population;Doctor of Philosophy;Education;Education Gap;education resources;Educational Curriculum;Event;experience;Experimental Designs;Exposure to;Faculty;falls;Feedback;Funding;Future;graduate school;grasp;Hand;higher education;innovation;interest;Journals;Laboratories;Leadership;Learning;longitudinal course;matriculation;medical schools;member;Mentors;Mentorship;Methodology;Neurobiology;Neurosciences;Neurosciences Research;next generation;Outcome;Participant;pedagogical content;peer;Population;Postbaccalaureate;programs;Reproducibility;Research;Research Design;Research Ethics;Research Support;Research Training;responsible research conduct;Role;Science;skills;stem;Students;success;Surveys;System;Talents;Testing;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: PiNBAC: The Program in Neuroscience Post-Baccalaureate Training Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE:  Checkpoint blockade immunotherapy has been a great advance in oncology, but still only benefits a minority of patients. We have developed a novel immunotherapy – in situ vaccination (ISV) – which induces clinical remissions in patients with lymphoma and greatly increases the efficacy of PD1-blockade in a pre-clinical model. This prompted a new, recently opened trial combining ISV with PD1 blockade. Here, we will perform basic immunology studies to improve our understanding of the ISV and PD1-blockade, in previously banked and unidentified patient samples and in the animal model.

PI_NAMEs: BRODY, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Agonist;Animal Model;anti-PD-1;anti-PD1 therapy;Antigen-Presenting Cells;antigen-specific T cells;antitumor effect;Autologous;Blood;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;chemokine;Clinical;clinical remission;Clone Cells;Coculture Techniques;Cross Presentation;cross reacting material 197;Cross-Priming;cytokine;Dendritic Cells;Disease remission;Distant;FLT3 ligand;Genetic;Goals;Hepatitis B Surface Antigens;Hodgkin Disease;immune checkpoint blockade;Immune system;Immunologic Monitoring;Immunology;Immunotherapy;improved;in situ cancer vaccination;in situ vaccination;Indolent;Infiltration;insight;Knowledge;Lymphoma;Measures;Mediating;Methods;Minority;Modeling;Molecular;mouse model;Mus;Mutation;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;novel;Oncology;Outcome;Patient Monitoring;patient subsets;Patients;PD-1 blockade;pembrolizumab;Phenotype;Pre-Clinical Model;predict clinical outcome;preservation;prevent;Production;programmed cell death ligand 1;programmed cell death protein 1;Radiation therapy;recruit;Resistance;resistance mechanism;response;Sampling;single-cell RNA sequencing;Site;Sorting;T cell receptor repertoire sequencing;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic Effect;tumor;Tumor Antigens;tumor microenvironment;Tumor Suppression;usability;Work

PROJECT_TITLE: Potentiating Checkpoint Blockade by Cross-Priming Tumor-Reactive T cells with In Situ Vaccination

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: NARRATIVE/Public Health Relevance Statement Transcription represents a means by which the human genome is decoded in each of our cells. Regulation of transcription is fundamentally important to maintain normal growth and development, whereas breakdown in transcription regulation underlies many diseases including cancer, heart disease, and neurological disorders. In this study, we seek to apply diverse and complementary approaches to uncover molecular mechanisms that drive developmental or disease-related transcriptional programs in human cells; we anticipate that the mechanistic insights gained will enable development of novel strategies to therapeutically target aberrant transcription in human cells.

PI_NAMEs: TAATJES, DYLAN J (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Area;Biochemical;Biological Assay;Biology;Cells;Chemicals;Code;Communication;Complex;Development;Disease;DNA Binding;DNA Polymerase II;Enhancers;Enzymes;experimental study;follow-up;Gene Expression;Genes;Genetic Transcription;genome editing;genome-wide;Goals;Growth and Development function;Heart Diseases;Human;Human Genome;In Vitro;in vitro Assay;insight;Liquid substance;Location;Malignant Neoplasms;Mediator;Methods;Modeling;Molecular;Nervous System Disorder;novel strategies;Nucleic Acids;Oncogenic;Phase;Phosphotransferases;Physical condensation;Polymerase;Population;Positive Transcriptional Elongation Factor B;programs;promoter;Proteins;public health relevance;reconstitution;Regulation;Research;RNA;RNA Polymerase II;RNA Processing;Signal Transduction;success;System;Testing;therapeutic target;Transcription Elongation;transcription factor;Transcription Factor TFIIA;transcription factor TFIIH;Transcription Initiation;Transcriptional Regulation;transcriptomics;Untranslated RNA;Work

PROJECT_TITLE: Mechanisms of RNA polymerase II transcription regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Vascular disease and osteoporosis tend to occur together in older adults. This project will use state-of-the-art measures of blood flow and advanced bone microarchitecture imaging technology to determine the vascular mechanisms underlying skeletal fragility. Findings from this project will provide new targets needed for treatment and screening to identify individuals at high risk and reduce the public health burden of fracture.

PI_NAMEs: SAMELSON, ELIZABETH J (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Affect;Age;age related changes;Aging;aging related;Anatomy;Aorta;Area;Arteries;Blood flow;Blood Vessels;bone;Bone Density;bone fragility;bone loss;bone strength;Bone structure;brachial artery;Callback;Cardiovascular system;Clinical;cohort;Communities;cortical bone;Data;Deterioration;Diabetes Mellitus;Discontinuous Capillary;Dual-Energy X-Ray Absorptiometry;effective intervention;Elderly;Elements;Epidemic;Etiology;experience;Failure;follow-up;Fracture;fracture risk;fragility fracture;Framingham Heart Study;Goals;Guidelines;hemodynamics;high risk;high risk population;Imaging Techniques;Imaging technology;Impairment;improved;Incidence;indexing;Individual;innovation;insight;Intervention;Investigation;Knowledge;long bone;Marrow;Measurement;Measures;member;men;Microcirculation;Microvascular Dysfunction;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Older Population;Organ;Osteoporosis;Outcome;Participant;Patients;Perfusion;Peripheral;Population;population based;Porosity;pressure;prevent;Prevention;Prevention strategy;Primary Prevention;Property;prospective;Public Health;public health relevance;Pulse Pressure;Resolution;response;Risk;Risk Reduction;Role;Scanning;screening;Site;skeletal;Skeleton;Spinal Fractures;Structure;substantia spongiosa;Testing;tonometry;tool;transmission process;Vascular blood supply;vascular contributions;Vascular Diseases;Visit;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Vascular Mechanisms Underlying Skeletal Fragility in Older Adults


NIH_SPENDING_CATS: Aging;Digestive Diseases;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Post-natal maturation in mammals is associated with significant changes in diet and microbiota, requiring corresponding changes in digestive behaviors which are heavily regulated by the neurons of the Enteric Nervous System (ENS). To accommodate these changes and to maintain the structural and functional integrity of the ENS, enteric neurons are continually replenished by dedicated and distinct juvenile and adult Enteric Neural Stem Cells (ENSC) by processes that become less robust with aging leading to neuronal insufficiencies and associated intestinal dysmotilities. In this study, we will identify and test key Juvenile Protective Factors (JPFs) that regulate and enable neurogenesis in juvenile ENSC, which may be re-introduced as potential therapies in the aging gut to supplement insufficient neuron production and improve aging-associated intestinal dysfunction.

PI_NAMEs: GOFF, LOYAL ANDREW (contact);KULKARNI, SUBHASH

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Adolescent;Adult;adult neurogenesis;Affect;Age;age related;Aging;aging related;Animal Model;Behavior;Biological;Brain;cell behavior;Cell Physiology;Cells;Chronic;Collection;computerized tools;Cues;Data;Death Rate;Dedications;Development;Diet;Disease;Elderly;Enteral;Enteric Nervous System;fetal;Functional disorder;Gene Expression Profile;Goals;Health;improved;in vivo;injured;Injury;injury and repair;insight;Intestinal Motility;Intestines;Life;Location;Maintenance;Mammals;Measurement;mechanical force;microbial;microbiota;Molecular;Motility;motility disorder;Mus;nerve stem cell;nestin protein;neurogenesis;Neuroglia;neuron loss;Neurons;next generation sequencing;normal aging;novel;novel strategies;older patient;Pathologic;Pathway interactions;Patients;Phase;Population;postnatal;postnatal development;Process;Production;protective factors;Proteome;Quality of life;recruit;regenerative therapy;repair function;repaired;Resolution;Rest;Resuscitation;Role;Source;stem cells;stressor;Structure;Testing;Therapeutic;Time;Toxin;transcriptome;transcriptomics

PROJECT_TITLE: Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Estrogen;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Women's Health Research

ORG_CITY: SHREVEPORT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Women have an increased rate (3-fold higher than men) of stress-induced myocardial infarction (MI). The mechanisms responsible for women’s susceptibility to the effects of stress are unknown. Our goal is to further our understanding of stress gender-specific effects in MI to formulate new translatable therapeutic interventions. !

PI_NAMEs: CRUZ TOPETE, DIANA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Affect;Age;Age Years;American;antagonist;Apoptosis;Apoptotic;Binding;biological adaptation to stress;Biological Assay;Cardiac;Cardiac health;Cardiac Myocytes;cardioprotection;Cardiovascular system;career;career development;Caspase;Cause of Death;Cell Death;Cell membrane;Cells;Cessation of life;chromatin immunoprecipitation;Complex;Cytochromes;Cytoplasm;Data;depressed patient;Disease;Elements;ESR1 gene;Estrogen Nuclear Receptor;Estrogen Receptors;Estrogens;Exposure to;Female;Flow Cytometry;Funding;Funding Mechanisms;Gender;Gene Expression;Genes;Genetic Polymorphism;Genetic Transcription;Genomics;Genus Hippocampus;Glucocorticoid Receptor;Glucocorticoids;Goals;Gonadal Steroid Hormones;Grant;GRP gene;Health;Heart;Heart Diseases;Heart failure;heart function;high risk;Hormone Receptor;Hormones;Human;human female;Hypoxia;improved;In Situ Nick-End Labeling;in vivo;Incidence;Incubated;Infarction;Injury;Institution;Ischemia;Knock-out;Lead;Link;MAPK3 gene;Measures;Mediating;Membrane Potentials;men;Mentors;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;mortality;mortality risk;Mus;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardium;Nuclear Envelope;Nuclear Receptors;Outcome;Oxygen Consumption;Pathway interactions;Permeability;Pharmacological Treatment;Physiological;Predisposition;Prevalence;promoter;protective effect;Proteins;Protons;Receptor Inhibition;Receptor Signaling;Recovery;Recurrence;Regulation;Reperfusion Injury;Reperfusion Therapy;Repression;Research;response;Risk;Risk Factors;Sampling;Serotonin;serotonin 5 receptor;serotonin receptor;Serotonin Receptor 5-HT2B;sex;sexual dimorphism;Signal Pathway;Signal Transduction;skills;SLC25A4 gene;Small Interfering RNA;Stains;Stimulus;Stress;System;Testing;Therapeutic Intervention;Training;Transcriptional Regulation;Western Blotting;Woman;women's clinical trial;Writing

PROJECT_TITLE: Molecular Mechanisms of Stress Signaling in the Female Heart


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Since the utility of breast cancer screening in later life varies according to women's life expectancy, risk of breast cancer, and preferences, experts and guidelines recommend that primary care clinicians engage women aged 75 and older in shared decision making around mammography screening (meaning that primary care clinicians inform women of the possible benefits and harms of screening, elicit patient values and preferences, and together decide on a course of action); however, primary care clinicians report feeling ill- prepared and request support for these conversations. Therefore, with help from primary care clinicians, women aged 75 and older, their family members, medical assistants, and other expert stakeholders, we aim to develop and test in diverse “real-world” primary care practices an easy-to-use, flexible, and adaptable, interactive web-based conversation aid that will provide personalized estimates of the benefits and harms of mammography screening for older women using the most up-to-date data and simulation modeling methods. We anticipate that use of our conversation aid will allow primary care clinicians to feel more supported and prepared to engage older women in shared decision making around mammography screening and as a result older women will make more informed decisions around mammography screening consistent with their values.

PI_NAMEs: SCHONBERG, MARA A (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Age;aged;Area;arm;Back;behavior prediction;Behavioral Model;Boston;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;Cancer Intervention;Cancer Intervention and Surveillance Modeling Network;Caring;Cessation of life;Characteristics;Clinical;clinical encounter;Communities;comorbidity;Data;Decision Aid;Decision Making;design;Detection;Diagnosis;Effectiveness;experience;Face;Family;Family member;Feeling;flexibility;Funding;Future;Goals;Guidelines;Health;high risk;Home;implementation design;implementation science;improved;Incentives;Individual;Intervention;Interview;late life;Learning;Life;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Medicare;Methods;Modeling;models and simulation;Moral Obligations;mortality;next generation;novel;Nurse Practitioners;older adult;older women;Online Systems;Outcome;Output;Pamphlets;Participant;Patients;payment;Perception;personalized care;Physicians;Pilot Projects;pilot test;Population;pragmatic trial;Pre-Post Tests;preference;Primary Care;primary care clinician;primary care practice;primary care provider;primary care team;primary care visit;programs;prototype;Race;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research Personnel;Risk;routine screening;safety net;satisfaction;screening;Self Efficacy;shared decision making;support tools;surveillance network;Testing;tool;Training;tumor;Visit;web-based tool;wellness visit;Woman;Women's Health;Women's mortality;women's outcomes;Work;young woman

PROJECT_TITLE: A Conversation Aid on Mammography Screening to Support Shared Decision Making between Clinicians and Women Aged 75 and Older

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Back Pain;Behavioral and Social Science;Caregiving Research;Chronic Pain;Clinical Research;Pain Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE  The prevalence of chronic low back pain (CLBP) in older adults is growing and treatment of CLBP in the Medicare population increased three-fold in recent years. Spouses are a key source of support and assistance to many older CLBP patients but ongoing exposure to patients’ suffering is likely to take a toll on spouses’ well- being and ability to provide effective support. The proposed research is aimed at identifying a key context, daily variations in relationship closeness, in which spousal caregivers are most affected by patients’ pain and likely to respond in ways that compromise patients’ function over the longer term.

PI_NAMEs: MARTIRE, LYNN M. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Affect;American;Area;Behavior Control;Behavioral;Caregiver well-being;Caregivers;caregiving;Characteristics;Chronic;Chronic Disease;Chronic low back pain;chronic pain;Cognitive;cost;Couples;daily pain;depressive symptoms;design;Dimensions;disability;Disadvantaged;Distress;Elderly;Emotional;Empathy;experience;Exposure to;Growth;Health;health care service utilization;High Prevalence;improved;innovation;Intervention;Interview;intimate behavior;Late Effects;late life;Link;Marital Relationships;Measures;Medicare;Modeling;novel;older adult;older patient;Outcome;Pain;pain patient;Patients;Personal Satisfaction;Persons;Physical Function;physical symptom;Population;pressure;Prevalence;Process;prospective;Reporting;Research;Research Design;response;Sampling;satisfaction;Severities;sex;Source;Spouse Caregiver;Spouses;symptomatology;Symptoms;Tablet Computer;Testing;Variant;Work

PROJECT_TITLE: Diverging Effects of Closeness in Older Adults with Chronic Low Back Pain and Spousal Caregivers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Immunotherapy;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Immunosuppression is a major risk factor for non-healing wounds, indicating that signals derived from immune cells are necessary for optimal repair. Yet, exactly how lymphocytes are activated in wounds and their molecular dialogue with injured epithelium is ill defined. The goal of this proposal is to understand how type 17 immune cells are activated in response to injury and elucidate their mechanistic crosstalk with the epithelium.

PI_NAMEs: NAIK, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;Activated Lymphocyte;Address;Affect;Animals;Autoimmune;Binding;Cancerous;Cell Hypoxia;cell type;Cells;Chronic;chronic wound;Communication;cost estimate;Coupling;cytokine;Cytokine Signaling;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Dermal;differential expression;Epithelial Cells;epithelial injury;epithelial stem cell;epithelial wound;Epithelium;Failure;Genetic Transcription;Goals;healing;Health;Hypoxia;hypoxia inducible factor 1;IL17 gene;Immune;Immunity;Immunocompetent;Immunologist;Immunosuppression;Immunotherapy;Impaired wound healing;Impairment;in vivo;Inflammation;Inflammatory;injured;Injury;innovation;insight;Interleukin Receptor;Interleukins;Intervention;Knowledge;Lymphocyte;Lymphoid Cell;Malignant Neoplasms;Maps;Measures;Mediating;Memory;microbial;migration;Molecular;Molecular Target;mouse genetics;Mucous Membrane;Mus;new therapeutic target;non-healing wounds;novel;pathogen;Pathology;Pathway interactions;Population;Positioning Attribute;Predisposing Factor;Production;programs;Proteins;prototype;re-epithelialization;receptor;recruit;Regulatory T-Lymphocyte;repaired;Resolution;response;response to injury;Risk Factors;Role;Science;Signal Induction;Signal Transduction;Site;Skin;Specialist;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;therapeutic target;Thromboplastin;Time;tissue repair;Tissues;transcription factor;transcriptomics;wound;wound healing;γδ T cells

PROJECT_TITLE: Mechanisms of immune-epithelial crosstalk in tissue repair

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE: Alzheimer's disease is not restricted to the gray matter regions of the brain but also affects the white matter, and these changes contribute to cognitive decline. We propose to evaluate the contributions of genetic variants to the development of oligodendrocyte dysfunction and myelin integrity loss in Alzheimer’s disease using postmortem human tissue samples. We will then conduct gene expression studies to identify underlying molecular mechanisms.

PI_NAMEs: KOFLER, JULIA K (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Acceleration;Affect;Age;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Astrocytes;Attention;Autopsy;Axon;Biological;Biology;Biometry;Blood Vessels;Brain;Brain region;brain tissue;burden of illness;Candidate Disease Gene;Cell Physiology;cell population study;cell type;Cessation of life;cohort;Complement;Data Analyses;Data Set;Deposition;design;Development;digital;digital imaging;Disease;Disease Progression;DNA Damage;endophenotype;experimental study;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;Genotype;gray matter;Growth Factor;Human;human tissue;hyperphosphorylated tau;hypoperfusion;Image Analysis;immunohistochemical markers;Impaired cognition;Inflammation;inflammatory marker;insight;interest;Investigation;ischemic injury;Knowledge;Link;Machine Learning;Maintenance;Measures;Mediator;Methods;Microscopic;Molecular;Myelin;nano-string;Nerve Degeneration;Neuroglia;neuroimaging;Neurons;neuropathology;new therapeutic target;novel;novel marker;Oligodendroglia;Optics;Pallor;Pathology;Pathway Analysis;Phenotype;Population;Process;protein aggregation;regional difference;Reporting;Research;Research Design;Research Personnel;risk variant;Role;sex;Sex Differences;SNP array;Stains;Stratification;Structure;Synapses;tau Proteins;tau-1;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissue Sample;tool;trait;transcriptome sequencing;transcriptomics;white matter;White Matter Disease;White Matter Hyperintensity;whole slide imaging

PROJECT_TITLE: Genetic and molecular correlates of white matter pathology in Alzheimers disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: There is a paramount need for clinician scientists who are skilled in modern scientific methods and have the background to develop novel approaches to prevent, diagnose, and treat Alzheimer’s disease and related dementias (ADRDs). The Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency (CARiNG-StARR) program will provide protected research time for residents- investigators in the departments of Family Medicine, Psychiatry and Behavioral Sciences, and Neurology to foster their maturation into independent physician-scientists who use cutting-edge research methods to pursue long-term academic careers investigating important issues related to ADRD.

PI_NAMEs: VIERA, ANTHONY J (contact);WHITSON, HEATHER E.

PROJECT_TERMS: Achievement;Address;Aging;aging population;Alzheimer's disease related dementia;Applications Grants;Area;Award;Basic Science;Behavioral Sciences;Biomedical Research;Board Certification;career;career development;Caring;Chronic Disease;Clinic;Clinical;clinical care;Clinical Research;clinical training;clinical translation;Communication;comorbidity;Country;Development;Development Plans;Diagnosis;Discipline;Disease;Disparity;Doctor of Philosophy;Educational Curriculum;Eligibility Determination;Ensure;Epidemiology;Equity;Evaluation;evidence base;experience;Extramural Activities;Faculty;Family Practice;Fellowship;Fostering;Funding;Geriatrics;Goals;Grant;Health;health disparity;health equity;Human Development;human old age (65+);improved;Individual;innovation;insight;Institution;interest;Intervention;Journals;Knowledge;life span;Link;Manuscripts;Medical;Medical Ethics;medical schools;meetings;Mentors;Methods;Mission;Modality;Modeling;Modernization;multidisciplinary;Neurology;Neurosciences;next generation;novel;novel strategies;Peer Review;Persons;Physicians;Physicians' Offices;Play;Population;Positioning Attribute;preference;prevent;Prevention strategy;programs;Psychiatry;Request for Applications;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Role;Scholarship;Scientist;skills;Social Sciences;Structure;success;Time;tool;Training;Translational Research;United States National Institutes of Health;Universities;Wages;War;Work;Writing

PROJECT_TITLE: Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)"


NIH_SPENDING_CATS: Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Defects in nuclear positioning disrupt development in many mammalian tissues and nuclear migration through constricted spaces is important for metastasizing cancer cells and during inflammation. LINC complexes play many important cellular functions including nuclear positioning, homolog pairing in meiosis, DNA damage repair, wound healing, spermatogenesis, and the formation of nuclear pore complexes. The proposed research is relevant to public health because nuclear positioning and mutations in LINC components are associated with a wide variety of human diseases including muscular dystrophies, neurological disorders, Progeria, aneurysms, hearing loss, blindness, sterility, and multiple cancers. Thus, our studies are significant for understanding the molecular underpinnings of a wide variety of cell and developmental processes, and for elucidating how LINC complexes contribute to disease.

PI_NAMEs: STARR, DANIEL A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Address;Aneurysm;Architecture;ATP phosphohydrolase;Auxins;Biological Assay;Biophysics;Blindness;Caenorhabditis elegans;cancer cell;Cell Nucleus;Cell Physiology;Cells;Collaborations;Complement;Complex;constriction;Cytoplasm;Cytoskeleton;Data;Defect;Development;Developmental Process;Disease;disulfide bond;DNA Repair;Dynein ATPase;env Gene Products;Eukaryota;Event;Evolution;Future;genetic approach;Genetic Screening;Giant Cells;hearing impairment;Homologous Gene;human disease;In Vitro;Inflammation;innovation;Kinesin;Knowledge;Malignant Neoplasms;Mediating;Meiosis;Microtubules;migration;Minus End of the Microtubule;Mitochondria;Modeling;Molecular;Motor;Motor Activity;Movement;Muscular Dystrophies;mutant;Mutation;Nervous System Disorder;Nuclear;Nuclear Envelope;Nuclear Outer Membrane;Nuclear Pore Complex;Organelles;Play;Positioning Attribute;Progeria;Protein Disulfide Isomerase;Protein Isoforms;Proteins;Public Health;Reagent;Research;Spermatogenesis;Sterility;Surface;System;tissue/cell culture;Tissues;Total Internal Reflection Fluorescent;transmission process;wound healing

PROJECT_TITLE: Mechanisms of Nuclear Migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: COLUMBIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: We will develop a predoctoral training program that will provide opportunities for research training leading to a PhD degree to predoctoral graduate students from groups that are underrepresented in the biomedical workforce. Our program will develop these students into independent scientists who are active producers of new biomedical knowledge and are adept at solving the complex problems of disease and illnesses that adversely affect human health. As these students will pursue careers in biomedical research, our program will enhance the diversity of the biomedical research workforce.

PI_NAMEs: SCHRUM, ADAM G. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: IMSD: An Initiative to Maximize Student Development in Biomedical Research at MU

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Dr. Chirinos proposes to augment his scientific skills and program building, continue to develop the local environment for mentoring new clinical investigators who perform patient-oriented research about arterial aging and HFpEF, and conduct studies that will impact our understanding of the genetic determinants of aortic stiffness.

PI_NAMEs: CHIRINOS MEDINA, JULIO ALONSO (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Age;age related;Aging;aging population;Aorta;Aortic Segment;aortic valve;arterial tonometry;ascending aorta;Award;biobank;Biological;burden of illness;calcification;career;career development;Clinical;clinical imaging;Clinical Investigator;clinical practice;Clinical Sciences;Collaborations;Data;Dedications;deep learning;Deposition;Development;Diameter;Distal;Doctor of Philosophy;Echocardiography;EFRAC;Elasticity;Elastin;electric impedance;Electrocardiogram;Enrollment;Environment;Epidemiology;epidemiology study;Equation;Equipment;Exhibits;exome;experience;Faculty;Femur;Fibrosis;Generations;Genetic Determinism;Genetic study;genome wide association study;genomic data;Genomics;Goals;Health;Heart failure;hemodynamics;Heritability;Human;Image;imaging study;improved;Individual;infancy;innovation;insight;Institution;interest;K-Series Research Career Programs;large datasets;Leadership;Left;Length;Location;Magnetic Resonance Imaging;Measurement;Measures;medical schools;Medicine;meetings;Mendelian randomization;Mentors;Mentorship;Methodology;Methods;mid-career faculty;multidisciplinary;Muscle;next generation;next generation sequencing;novel;Participant;Pathologic Processes;patient oriented;patient oriented research;Patients;Pennsylvania;Phenotype;Physicians;Physiologic pulse;Play;Population;Population Study;preservation;Prevention approach;Process;Productivity;Professional Organizations;programs;prospective;Research;research and development;Research Personnel;research study;Resources;Respiratory Diaphragm;Rest;Role;Sample Size;Science;Scientist;Site;skills;success;Surface;System;Thoracic aorta;Time;time use;Training;Training Support;Translational Research;translational study;ultrasound;Universities;Ventricular;Work

PROJECT_TITLE: Genetic determinants of thoracic aortic stiffness and remodeling

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Patients with cancer on blood thinners are at high-risk of bleeding, including bleeding related death. Bleeding risk can be predicted through prediction models in non-cancer populations, but no prediction model is validated for use in patients with cancer. We will develop a prediction model to quantify the risk of bleeding in patients with cancer, which will allow healthcare providers to tailor length and intensity of anticoagulant therapy to individual risk of bleeding.

PI_NAMEs: SANFILIPPO, KRISTEN MARIE (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Anticoagulant therapy;Anticoagulants;Area;Atrial Fibrillation;burden of illness;Calibration;Cancer Burden;Cancer Patient;cancer risk;Cessation of life;clinical predictive model;Clinical Trials;cohort;Data;Development;Diagnosis;Discrimination;Effectiveness;Enrollment;Equilibrium;evidence base;Fatality rate;Goals;Guidelines;Health Personnel;Hemorrhage;high risk;high risk population;High-Risk Cancer;Histology;improved;Individual;innovation;Intervention;Knowledge;Length;Location;Malignant Neoplasms;Methods;Modeling;Morbidity - disease rate;mortality;National Comprehensive Cancer Network;novel;Oral;Patient Care;patient oriented;Patients;Performance;Periodicals;personalized approach;Population;Positioning Attribute;predictive modeling;prevent;Prevention;Prevention approach;Prophylactic treatment;Provider;randomized trial;Recommendation;Recurrence;Research;Risk;Risk Factors;risk prediction model;Risk-Benefit Assessment;success;Thrombosis;Time;time use;treatment center;Treatment-Related Cancer;tumor;United States;Venous;venous thromboembolism

PROJECT_TITLE: Prediction of Anticoagulant-Related Bleeding Risk in Patients with Cancer

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: The overarching goal of this proposal is to establish IL22/IL22R1 as a novel signaling axis that regulates the astrocytic reaction, which in turn influences brain homeostasis and promotes epileptogenesis. The results from this study will provide new insights into astrogliosis and lead to new therapeutic targets to combat epilepsy.

PI_NAMEs: HUANG, YUNFEI  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Antibodies;Astrocytes;astrogliosis;Atopic Dermatitis;Attenuated;Biological Products;Brain;brain parenchyma;Cell Communication;Cells;Characteristics;Clinical Trials;combat;cytokine;Disease;DNA Sequence Alteration;druggable target;Encephalitis;Epilepsy;Epileptogenesis;Etiology;glymphatic system;Goals;Homeostasis;Human;Immune;Immunohistochemistry;Immunologics;immunoreaction;improved;Individual;Infection;Infiltration;Inflammatory;Injections;Injury;insight;Interleukin-1 beta;interleukin-22;Lead;Lymphoid Cell;Macrophage;Mediating;Meninges;Microglia;Modeling;mouse model;Mus;Neurologic;neuronal excitability;Neuronal Injury;Neurons;neutralizing antibody;new therapeutic target;novel;Pathologic;Pathologic Processes;Peripheral;Phase II Clinical Trials;Pilocarpine;Play;preclinical study;prevent;Process;Proliferating;Reaction;receptor;recruit;Regulation;Reporter;response;response to injury;Role;Safety;Signal Transduction;Status Epilepticus;Surface;System;T-Lymphocyte;Temporal Lobe Epilepsy;Testing;tissue repair;TNF gene;Translating;Up-Regulation;Western Blotting

PROJECT_TITLE: IL22 Signaling in Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two devastating and fatal neurodegenerative disorders that are clinically distinct but show an overlap in brain pathology and genetic factors, but the mechanistic basis of their shared and distinct circuitry remains unknown at the molecular level, which prevents the identification of needed therapeutic targets. Here, we use single-cell high-resolution profiling of epigenomic and transcriptional alterations in post-mortem brain samples from ALS and FTLD patients to elucidate their underlying mechanism of action, shed light on their common and distinct circuitry, bridge the gap between genetic variation and highly polygenic complex traits in ALS and FTLD, and identify new therapeutic targets for these devastating disorders.

PI_NAMEs: BELZIL, VERONIQUE ;KELLIS, MANOLIS  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Address;Adult;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Autopsy;Bayesian Method;Biological;Brain;Brain Pathology;Brain region;Candidate Disease Gene;career;Cell Differentiation process;Cell model;cell type;Cells;Clinical;Coculture Techniques;Communities;Complex;CRISPR screen;Data;Data Set;Development;differential expression;Disease;Dissection;Distal;DNA;Enhancers;Epigenetic Process;epigenomic profiling;epigenomics;experimental study;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic information;genetic signature;Genetic Transcription;Genetic Variation;genome wide association study;genomic locus;Human;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Link;Maps;Mediating;Mediation;middle age;Modeling;Molecular;Motor Cortex;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Pathologic;Pathway interactions;Patients;Phenotype;predictive signature;Prefrontal Cortex;prevent;promoter;Regulatory Element;Resolution;Resources;risk variant;Sampling;single cell ATAC-seq;Single Nucleotide Polymorphism;single-cell RNA sequencing;Techniques;Therapeutic Intervention;therapeutic target;trait;Transcription Alteration;transcriptome;Untranslated RNA;Variant

PROJECT_TITLE: Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Degradation of high molecular weight multimers of von Willebrand factor leading to acquired von Willebrand syndrome (AvWS) is still a primary complication in using the continuous-flow blood pumps. In this study, we will characterize the degradation mechanism of the protein in terms of mechanoenzymatic, mechanistic, and enzymatic sensitivity through comprehensive vWF biology and fluid dynamics. The outcome will be used to develop a model to be a tool for device design optimization leading to a next-generation blood pump and better clinical outcomes for patients with AvWS.

PI_NAMEs: JHUN, CHOON-SIK  (contact)

PROJECT_TERMS: Acquired von Willebrand disease;ADAMTS;Address;Adsorption;Alpha Granule;American Heart Association;Aortic Valve Stenosis;Automobile Driving;Award;Binding;Biology;Blood;Blood Coagulation Disorders;Blood flow;Blood Platelets;blood pump;Budgets;Clinic;Clinical;clinical decision support;clinical effect;clinically relevant;clinically significant;cohort;Complication;Custom;Data;density;design;Device Designs;Device Removal;Devices;Doctor of Medicine;Doctor of Philosophy;Enzymes;Event;Excision;experimental study;Funding;Goals;Hemorrhage;Hemostatic Agents;Human Resources;Implant;in silico;In Vitro;in vitro testing;in vivo;innovation;Institutional Review Boards;Kinetics;left ventricular assist device;Liquid substance;Literature;Mechanics;Mediating;Medical center;Metabolism;Metalloproteases;Methodology;Modeling;Molecular Weight;next generation;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Physicians;prospective;Proteins;Publications;Reaction Time;Role;Scientist;shear stress;Site;Source;Structure;support tools;Surface;Syndrome;Testing;Time;tool;von Willebrand Factor;Work

PROJECT_TITLE: Multimeric Structural Degradation of vWF in Turbulent Flows

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: It is imperative that all available talent from a progressively diverse US population is utilized to foster innovation and advance our ability to effectively prevent or treat neurological diseases. Part of this effort will require a firm commitment to training and supporting budding researchers from diverse backgrounds. The TRANSCENDS Program will train, mentor, and sustain a network of diverse neurologists committed to developing independent academic careers in clinical neuroscience research.

PI_NAMEs: OVBIAGELE, BRUCE  (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Academia;Academic Training;Academy;access restrictions;Achievement;Affect;African American;American;Applications Grants;Area;Asian;Award;Benchmarking;Biomedical Research;Black race;career;career development;Career Mobility;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;Course Content;Credentialing;Data;Databases;Dedications;Degree Completion;Degree program;design;Development;disability;Disabled Persons;Discipline;Disparity;Drops;early-career faculty;education research;effectiveness evaluation;Elements;ethnic minority;Event;evidence base;expectation;experience;Exposure to;Faculty;Feedback;Fellowship Program;Fortification;Fostering;Funding;General Population;Goals;Grant;Health Disparities Research;Hispanic;Hour;implicit bias;improved;innovation;Institution;Instruction;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Latinx;Leadership;Learning;Manuscripts;Master of Science;matriculation;Measures;Medical;medical schools;Medicine;meetings;member;men;Mentors;Mentorship;Minority Groups;Minority Participation;Minority Recruitment;Monitor;Motivation;Needs Assessment;Nervous System Disorder;Neurologic;Neurologist;Neurology;Neurosciences;Neurosciences Research;Newsletter;next generation;online course;Outcome;peer coaching;Peer Review;Physicians;Population;population health;Positioning Attribute;Postdoctoral Fellow;posters;pressure;prevent;Probability;programs;Public Health;Publications;Publishing;racial minority;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;role model;satisfaction;Schedule;Scientist;Services;Shapes;Site;skill acquisition;skills;Social Sciences;South Carolina;success;symposium;Talents;theories;Time;Training;United States National Institutes of Health;Universities;volunteer;web site;Woman;Writing

PROJECT_TITLE: Training in Research for Academic Neurologists to Sustain Careers and Enhance the Numbers of Diverse Scholars (TRANSCENDS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: The myelin sheath that wraps and insulates axons of the central nervous system is essential for the proper function of mammalian neural signaling. Degeneration or breakdown of myelin structure can be complicit in a large array of neurological disorders, such as multiple sclerosis, stroke, Alzheimer’s disease and age-related dementia. Currently there is no low-cost, rapid method for high-resolution imaging to quantify myelin breakdown across the whole brain of non-human primate animal models or humans, and our method of polarized-light microscopy will meet that critical need.

PI_NAMEs: BIGIO, IRVING J. (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;age related;age related neurodegeneration;Age-associated memory impairment;Aging;Alzheimer's Disease;Animal Model;Animals;Anisotropy;Architecture;Archives;arm;Autopsy;Axon;Behavioral;Biological Assay;Biological Markers;Birefringence;Boston;Brain;Brain imaging;brain tissue;Central Nervous System;Cephalic;Cognitive;cognitive testing;Computers;computing resources;cost;Cryopreservation;Darkness;Dementia;density;Diffusion Magnetic Resonance Imaging;Disease;Electron Microscopy;Exhibits;extracellular vesicles;hand dysfunction;Health;high resolution imaging;Human;Image;Imaging Device;Impaired cognition;in vivo;in vivo imaging;Injury;Label;light microscopy;Lighting;Macaca mulatta;Measures;Medical;Mesenchymal Stem Cells;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Modeling;Monkeys;Motor;Motor Cortex;motor deficit;motor recovery;Movement;Multiple Sclerosis;Myelin;myelin degeneration;Myelin Sheath;Nerve Degeneration;Nervous System Disorder;neural;neurophysiology;neurotransmission;nonhuman primate;normal aging;Optics;parallel computer;Pathology;pathology imaging;Peripheral Nerves;Phase;Polarization Microscopy;Positioning Attribute;Qualitative Methods;quantitative imaging;Quantitative Microscopy;Raman Spectrum Analysis;rapid technique;Recovery of Function;reflectance confocal microscopy;Refractive Indices;repaired;Reporting;Research Personnel;Resolution;Sampling;scale up;Stains;Stroke;Structure;Surveys;Sushi Domain;Testing;Therapeutic;Thick;Time;Tissue imaging;Tissues;tool;Universities;Validation;Vesicle;Work

PROJECT_TITLE: Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases

PHR: PROJECT NARRATIVE For more than 25 years, the collaboration among the Johns Hopkins University Bloomberg School of Public Health, the Universidad Peruana Cayetano Heredia in Peru, and A.B. PRISMA, a Peruvian non-governmental organization, has provided a rich environment for research and training. This collaboration is focused on developing local infrastructure and scientific talent in the area of infectious diseases, and we propose to continue to train and develop research and diagnostic capacity in Bolivia using our South-South training approach.

PI_NAMEs: GILMAN, ROBERT H (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Affect;Bolivia;Bolivian;Chagas Disease;co-infection;Communicable Diseases;Communities;cost;Country;Cysticercosis;Degree program;Developed Countries;Doctor of Philosophy;Ensure;graduate student;Grant;HIV;Human;Individual;Infrastructure;Institution;Investments;Journals;Laboratories;Master of Science;Methods;Modeling;Nationalities;Neurologic;Peer Review;Peru;Peruvian;Pneumonia;programs;Public Health;Qualifying;Research;Research Methodology;Research Personnel;Rotation;screening;Students;summer institute;Training;Training Programs;Tropical Medicine;Tuberculosis

PROJECT_TITLE: Infectious Diseases Training program in Bolivia: South-South Training with Peru

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: RNA interference in the animal C. elegans is highly focused on antiviral defense, with particular Argonaute proteins from its expanded set of small RNA armaments and RNA dependent RNA polymerase proteins highly specialized for silencing of integrated viruses and new invading viruses. The new genes we have discovered and our lists of new candidate genes identify the key elements in the choreography of small RNAs in C. elegans. Because these genes are nearly all conserved across phylogeny, the rules we work out may apply to humans, with importance for human health. These genes are likely to be key factors in the function of small RNAs, and our work may enable more potent RNAi-based drugs.

PI_NAMEs: RUVKUN, GARY B (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adenosine;adenosine deaminase;Alleles;Animals;Anticodon;Base Pairing;C. elegans genome;Caenorhabditis elegans;Cancer Biology;Candidate Disease Gene;Characteristics;Chimeric Proteins;Chorion;Chromosome Pairing;Chromosomes;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collagen Gene;Complex;Conceptions;COVID-19;Cytosine;Cytosine deaminase;Deaminase;Deamination;Dedications;deep sequencing;DNA;DNA amplification;DNA biosynthesis;DNA Double Strand Break;DNA sequencing;Double-Stranded RNA;Dreams;Drosophila genus;Dyes;Elements;Engineering;Enzymes;Future;Gene Amplification;Gene Modified;Gene Silencing;Generations;Genes;genetic analysis;Genetic Crossing Over;Genetic Recombination;Genetic Screening;Genome;Genomics;Germ Lines;Health;Human;Hybrids;Immunity;Infection;Informatics;Inosine;Intestines;Invaded;knock-down;Knock-in;Length;Ligation;Mediating;Messenger RNA;Modernization;Modification;mutant;Mutation;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phylogeny;Polyploidy;Production;Proteins;receptor;Recombinants;Regulation;Repetitive Sequence;Resistance;response;RNA;RNA Editing;RNA Helicase;RNA Interference;RNA Viruses;RNA-Directed RNA Polymerase;Small Interfering RNA;Small RNA;Stains;Subcutaneous Tissue;Surveys;System;Tandem Repeat Sequences;Testing;Tissues;Transfer RNA;Tumor Biology;Uracil;Variant;Viral;Virus;Virus Diseases;Virus Integration;Vitellogenins;Work

PROJECT_TITLE: Control of C. elegans Lineage by Heterochronic Genes

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative In the United States, sudden cardiac death accounts for 350,000 deaths per year with the leading cause being lethal ventricular arrhythmias. In this research, we propose a novel method to treat and manage ventricular arrhythmias – development of a new conductive material that can fill both large and small coronary vessels and convert these tributaries into flexible electrodes that span the scarred myocardium. We hypothesize that pacing from the hydrogel electrode will prevent VA and the increased activation area from these electrodes will offer a new platform for painless ventricular defibrillation.

PI_NAMEs: COSGRIFF-HERNANDEZ, ELIZABETH MARIE (contact);RAZAVI, MEHDI

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Anti-Arrhythmia Agents;Area;Biocompatible Materials;Cardiac;Cardiac ablation;cardiac resynchronization therapy;Cardiomyopathies;Catheters;Cessation of life;Chemistry;Cicatrix;Clinical;clinical translation;Contrast Media;Coronary Vessels;Custom;design;Development;Disease;efficacy validation;Electric Countershock;Electric Stimulation;Electrodes;Electrophysiology (science);Engineering;flexibility;flexible electronics;Frequencies;Genetic Complementation Test;Grant;grasp;Heart;heart rhythm;Heterogeneity;Human;Hydrogels;Implantable Defibrillators;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Injectable;innovation;Lead;Length;Life;Methods;minimally invasive;Modeling;Myocardial Infarction;Myocardial tissue;Myocardium;novel;Pacemakers;Pain;Pain Threshold;Painless;Physiologic pulse;porcine model;Positioning Attribute;prevent;psychological trauma;Quality of life;Research;Safety;safety assessment;Science;Shock;Site;Source;standard of care;Stimulus;Structure of left gastric vein;sudden cardiac death;Sudden Death;Surface;System;Technology;Thick;Tissues;tool;United States;Venous;Venous system;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Injectable Hydrogel Electrodes to Prevent Ventricular Arrhythmias


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Protecting the privacy of patients while also allowing data to be used for research is difficult. We will develop new methods that allow researchers to compute with patient data that can remain physically at originating healthcare institutions (and thus be kept under their control), and that can still be used for research involving both chronic and acute, rapidly evolving health conditions such as COVID-19.

PI_NAMEs: JIANG, XIAOQIAN ;OHNO-MACHADO, LUCILA  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Acceleration;Acute;Address;Algorithms;analytical tool;Artificial Intelligence;artificial intelligence algorithm;Calibration;California;Cessation of life;Chronic;Chronic Disease;Clinical;clinical decision support;clinical decision-making;combat;combinatorial;Communication;Consent;cost;Country;County;COVID-19;COVID-19 patient;COVID-19 risk;Data;Data Analyses;Data Discovery;data dissemination;data integration;Data Linkages;data modalities;data privacy;data sharing;Decentralization;design;Development;Disease;distributed data;Equilibrium;Evaluation;Event;federated data;federated learning;future outbreak;Genome;Geography;Goals;Health;Health Insurance Portability and Accountability Act;Health protection;Health Sciences;Healthcare;Heterogeneity;hospital readmission;Hospitalization;Image;Incidence;individual patient;Institution;Intervention;Knowledge;Laboratories;large datasets;Learning;Linear Models;Link;Literature;Marketing;Medical center;Methodology;Methods;Modality;model building;Modeling;Morbidity - disease rate;mortality;multimodality;new pandemic;novel;novel strategies;Outcome;outcome prediction;pandemic disease;Parents;patient privacy;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Phase;Phenotype;Population;Predictive Analytics;predictive modeling;Privacy;privacy preservation;privacy protection;Privatization;profiles in patients;Publishing;Reaction;Records;Recovery;Registries;repository;Research;Research Personnel;Resolution;Resource Allocation;Resources;Running;Sample Size;Security;Site;software development;Source;statistical learning;Structure;supervised learning;Techniques;Testing;Texas;Time;Training;transmission process;Underrepresented Minority;Universities;unsupervised learning;virtual;Visit

PROJECT_TITLE: Decentralized differentially-private methods for dynamic data release and analysis

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Visual perception and visually guided behaviors require the ability to rapidly store information in memory (e.g., so that information can be integrated across blinks and eye movements). The proposed research will provide a new understanding of how this visual memory system works in the context of the kinds of scenes that people encounter in daily life. This will be important for understanding, diagnosing, and treating the many disorders that involve impaired visual processing.

PI_NAMEs: LUCK, STEVEN J (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Algorithms;Architecture;Area;Attention;base;Behavior;behavior prediction;Behavioral;Blinking;Brain region;Categories;Classification;Code;Color;Complex;Computer Models;Consensus;convolutional neural network;Data;design;Detection;Diagnosis;Disease;Electroencephalography;Event-Related Potentials;experimental study;Eye Movements;Face;feeding;Frequencies;Functional Magnetic Resonance Imaging;Goals;Human;human subject;Individual Differences;insight;Learning;Life;Literature;Location;machine vision;Measures;Memory;Modeling;Nature;neural;Neural Network Simulation;neural patterning;Neurons;Neurosciences;Noise;object recognition;Pathway interactions;Pattern;Perception;Performance;Persons;Play;Population;Primates;Property;Proxy;Reporting;Research;response;Role;Sampling;Short-Term Memory;Specific qualifier value;Stimulus;Structure;Surface;System;Testing;theories;Training;vector;ventral visual stream;verbal;Vision;Visual;Visual impairment;visual memory;Visual Perception;visual processing;visual search;Vocabulary;Work

PROJECT_TITLE: Using Population Vectors to Understand Visual Working Memory for Natural Stimuli

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lymphatic Research;Lymphedema

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in our knowledge regarding the role of lymphatics in human diseases of sodium dysregulation. The goal of this work is to apply novel, noninvasive imaging tools to measure relationships between lymphatic function and tissue sodium in patients with well-characterized lymphedema. Findings are intended to inform mechanisms of lymphatic clearance of tissue sodium, and provide novel imaging biomarkers of lymphedema progression and treatment response.

PI_NAMEs: CRESCENZI, RACHELLE L (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adipose tissue;Affect;Age;aggressive therapy;Area;Assisted Circulation;Biological Markers;blood pressure control;Blood Vessels;Body mass index;cancer therapy;Cells;Chronic Disease;Clinical;Clinical Trials;comparison control;Cross-Sectional Studies;Data;Deposition;Disease;disease model;Early Intervention;Endometrial Carcinoma;Excision;Fibrosis;Functional disorder;Functional Imaging;Future;Goals;healthy volunteer;High Prevalence;Human;human disease;Image;imaging biomarker;Imaging Device;imaging modality;Immune;Impairment;in vivo;Inflammation;innovation;interstitial;Intervention;Knowledge;Leg;Limb structure;Longitudinal Studies;Lower Extremity;lymph flow;lymph nodes;lymph stasis;Lymphangiogenesis;Lymphangiography;Lymphatic;lymphatic circulation;Lymphatic clearance;Lymphatic Diseases;lymphatic dysfunction;Lymphatic function;lymphatic insufficiency;lymphatic vasculature;lymphatic vessel;Lymphedema;Lymphoid Tissue;Magnetic Resonance Imaging;Malignant Neoplasms;Manual Lymphatic Drainage;Manuals;Maps;Measurement;Measures;Mediating;Methods;Molecular;National Heart, Lung, and Blood Institute;non-invasive imaging;novel;novel marker;Operative Surgical Procedures;Patient Triage;Patients;Pharmacologic Substance;Physiology;potential biomarker;Procedures;Progressive Disease;Race;Radiology Specialty;Regulation;Reporting;Reproducibility;response;Risk;Risk Assessment;Rodent;Rodent Model;Role;secondary lymphedema;Severities;Severity of illness;Skin;Skin Tissue;Sodium;Source;Standardization;subcutaneous;subcutaneous fibrosis;Subcutaneous Tissue;Suction Lipectomy;Swelling;Technology;Testing;Therapeutic Intervention;Time;tissue biomarkers;Tissues;tool;treatment response;Tumor Debulking;Upper Extremity;Work;working group

PROJECT_TITLE: Imaging sodium and lymphatics in lymphedema

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Hematology;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Immune thrombocytopenia (ITP) is a common bleeding disorder that leads to a low platelet count and places patients at an increased risk for major (10%) or life-threatening bleeding (0.5%). Caring for these patients remains exceptionally challenging for physicians as they must weigh the significant side effects of all treatments with a qualitative estimate of the patient's risk for bleeding. Here, enabled by a tool capable of studying large numbers of individual platelet forces, this research seeks to understand if platelet force quantitatively assesses bleeding risk while also performing basic science research on the fundamental causes of the bleeding, both of which would significantly improve the quality of care for ITP patients.

PI_NAMEs: MYERS, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Actins;Adult;Affect;Basic Science;Biological Assay;Biological Markers;Blood Coagulation Disorders;Blood Platelets;Caring;Cells;Characteristics;Child;Clinical;Clinical Data;clinical practice;cohort;Cytometry;Data;demographics;Development;Diagnostic;Disease remission;droplet sequencing;Enrollment;experience;Exposure to;Fractionation;Genetic Transcription;Goals;Hematology;Hemorrhage;high risk;Idiopathic Thrombocytopenic Purpura;Immature Platelet;Immunoglobulin G;Immunologic Markers;Impairment;improved;Incubated;Individual;insight;Intracranial Hemorrhages;Investigation;Lead;Life;Life Experience;Longitudinal Studies;Measures;Monitor;Morphology;Myosin ATPase;Nature;novel;Outcome;Outcome Study;PAC1 phosphatase;Patient risk;Patients;pediatric patients;Phenotype;Physicians;Plasma;Platelet Activation;Platelet aggregation;Platelet Count measurement;platelet function;Platelet Function Tests;Platelet Transfusion;Process;prospective;Proteomics;Publishing;Quality of Care;Research;Resolution;Risk;Sampling;Series;side effect;Specificity;Structure;Symptoms;Techniques;Testing;Thrombelastography;Thrombocytopenia;Time;tool;Treatment Side Effects;unnecessary treatment;Validation;Visit;Work

PROJECT_TITLE: Leveraging platelet contraction cytometry for immune thrombocytopenia

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

PHR: Project Narrative  Neuropsychiatric symptoms such as apathy are major manifestations of Alzheimer's disease (AD) with tremendous clinical relevance. However, the link between apathy in AD and the underlying pathophysiology remains to be explained—we do not know whether brain circuits underlying apathy are the same or different than other AD symptoms such as impairment in cognition and instrumental activities of daily living. This is crucial for understanding whether apathy is truly a prodromal symptom of AD and for developing critically needed treatments for apathy and biomarkers for clinical trials.

PI_NAMEs: MARSHALL, GAD ASHER (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;amnestic mild cognitive impairment;Amyloid;amyloid pathology;Atrophic;Autopsy;Behavioral;behavioral impairment;Biological Markers;Brain;brain behavior;Clinical;Clinical assessments;Clinical Trials;clinically relevant;Cognition;Cognitive;connectome;cost;Cost Analysis;Dementia;depressive symptoms;Diffusion Magnetic Resonance Imaging;Dimensions;Distress;effective intervention;experience;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Funding;Future;Image;Impaired cognition;Impairment;in vivo;Individual;Inferior;instrumental activity of daily living;interest;Knowledge;Lateral;Link;Magnetic Resonance Imaging;Measures;Medial;Metabolism;mild cognitive impairment;Motivation;Multimodal Imaging;neural correlate;neurobehavioral;Neurobiology;Neurofibrillary Tangles;neuromechanism;neuropsychiatric symptom;non-demented;novel therapeutic intervention;older adult;Parietal;Participant;Pathologic;Pittsburgh Compound-B;Positive Valence;Positron-Emission Tomography;pre-clinical;Prevention strategy;Proxy;Public Health;Research;Rest;reward circuitry;Rewards;Severities;Symptoms;Thalamic structure;therapy development;Time;treatment response;treatment strategy;Visualization;white matter;Work;β-amyloid burden

PROJECT_TITLE: Neural Correlates of Apathy Across the Alzheimer's Disease Continuum


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The incidence of Hepatocellular Carcinoma (HCC), the most prevalent form of liver cancer, has been steadily rising in the United States. Although recurrent metabolic changes are observed in HCC, few studies have capitalized on altered metabolism to identify metabolic therapeutic targets in HCC. This proposal will study early metabolic alterations in HCC that may be therapeutically actionable to alleviate the burden of this deadly cancer on patients.

PI_NAMEs: KELEKAR, SHERWIN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Agar;Anchorage-Independent Growth;Benign;Biological Assay;Biology;blood glucose regulation;Cancer Etiology;Carbon;cell growth;Cell Line;Cell Proliferation;cell transformation;Cells;Cessation of life;Childhood;Cirrhosis;Clinical;Development;Diethylnitrosamine;Disease;Down-Regulation;Enzymes;Event;Evolution;Genes;Genetic;Germ Lines;Germ-Line Mutation;Glucose;glucose output;glucose-6-phosphatase;Glycogen;Glycogen Storage Disease;Growth;Hepatocarcinogenesis;Hepatocyte;Human;Immunohistochemistry;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;indexing;Injections;insight;Isotopes;Knockout Mice;Lead;Lipids;Liver;liver cancer model;liver cell proliferation;Liver Glycogen;liver injury;liver metabolism;Liver neoplasms;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Molecular;mouse model;Mus;Mutation;Nature;neoplastic cell;novel therapeutic intervention;Nucleotides;Oncogenes;Oncogenic;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Penetrance;Pentosephosphate Pathway;pharmacologic;Primary carcinoma of the liver cells;programs;Proliferating;Recurrence;Role;Sampling;Somatic Mutation;stable isotope;Tail;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;tool;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;tumorigenesis;United States

PROJECT_TITLE: The Role of Glucose-6-Phosphatase in Hepatocellular Carcinoma


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: BLUEGRASS ADVANCED MATERIALS, LLC

ORG_STATE: KY

PHR: Project Narrative In this project, a “smart” flocculant system is proposed to easily remove per- and polyfluoroalkyl substances (PFAS) from water systems, minimizing settling times and additional dewatering steps found in current flocculant technology. The novelty of the proposed polymer flocculant is that it combines a thermoresponsive compound (N-isopropylacrylamide (NIPAAm)) with cationic and fluorinated co-monomers. These co-monomers provide high affinity for PFAS molecules through a variety of interactions (e.g., electrostatic), which enhances affinity for PFAS compounds and greatly accelerates the flocculation and reduces the water retention in the resulting sediment, ultimately producing innovative smart flocculants with enhanced solid-liquid separation performance for removing PFAS from contaminated water.

PI_NAMEs: HAUSER, ANASTASIA  (contact);HILT, JAMES ZACH

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Affinity;American;aqueous;Behavior;Biodegradation;Carbon;Case Study;Child Behavior;Cholesterol;commercialization;contaminated water;copolymer;cost;cost effective;Country;Data;design;Development;drinking water;Dust;economic evaluation;effective therapy;Effectiveness;Electrostatics;Evaluation;Excision;experimental study;exposed human population;Family;Filtration;Flocculation;Food Packaging;Friction;Future;Goals;ground water;Growth;Health;Heating;Hormones;Hour;Human;hydrophilicity;Immune system;Industrialization;innovation;Ion Exchange;Ion Exchange Resins;Kinetics;landfill;learned behavior;Legal patent;Life Cycle Stages;Liquid substance;Malignant neoplasm of testis;man;manufacture;Marketing;Methods;microelectronics;N-isopropylacrylamide;nano;Natural regeneration;operation;Osmosis;Paint;Performance;Pesticides;Phase;Poa plant;Poly-fluoroalkyl substances;Polymers;Pre-Eclampsia;Prevalence;Process;Property;Recovery;Regulation;remediation;Renal Carcinoma;Residual state;Resistance;Resources;Risk;Route;Safety;Salts;simulation;Small Business Innovation Research Grant;Solid;Specificity;Stream;System;Techniques;Technology;Temperature;Transition Temperature;Treatment Step;Validation;wasting;Water;water flow;water sampling;water solubility;Water Supply;water treatment

PROJECT_TITLE: Development of Smart Flocculants for the Treatment of PFAS Contaminated Water

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Mitosis is the process by which duplicated sister chromosomes are evenly distributed to identical daughter cells, and in cancer cells, improper chromosome segregation during mitosis (e.g., such that chromosomes are unevenly distributed between daughter cells) is widely observed, and has been linked to poor prognosis, including decreased overall survival time and fewer treatment free years. In this study, we will make use of physical principles and advanced microscopy to evaluate the role of controlled forces in ensuring proper chromosome segregation during mitosis, and to dissect the role of microtubule structure in the targeting of microtubule- associated proteins. The results generated from our studies will be applicable both towards better understanding the fundamental biophysics of cell division, and also towards providing mechanistic information to shed light on current cancer therapies.

PI_NAMEs: GARDNER, MELISSA  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Binding;Binding Proteins;biophysical techniques;Biophysics;cancer cell;cancer therapy;Cell division;Cells;Cellular biology;Chromosome Segregation;Chromosomes;Computer Models;daughter cell;Ensure;genome integrity;Goals;insight;Laboratories;Length;Link;Microscopy;Microtubule-Associated Proteins;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;molecular scale;Process;Prognosis;Regulation;Role;Signal Transduction;Sister;Structure;Testing;Time;tool

PROJECT_TITLE: Gardner Lab MIRA Proposal: Microtubules and Mitosis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

ORG_STATE: MI

PHR: Active duty and reserve service members are at an increased risk of sustaining a traumatic brain injury (TBI) compared to civilians due to combat-related activities. In addition, Veterans who sustain a TBI are more likely to receive treatment with opioid-based medications for post-injury symptoms and are vulnerable to higher-risk opioid use patterns. Harmful consequences associated with this disproportionate use of opioid therapy demand the development of non-opioid based interventions for chronic symptom management in brain injured Veterans. Mechanisms associated with both TBI and opioid addiction include sustained neuroinflammation. Therefore, this proposal seeks to identify alterations in inflammatory processes and mediators, and test translationally-relevant, non-opioid based therapies in an effort to reduce the burden of TBI-related deficits and improve the quality of life for Veterans suffering from TBI.

PI_NAMEs: CONTI, ALANA C. (contact)

PROJECT_TERMS: Abate;active duty;addiction;Addictive Behavior;Address;Adverse effects;adverse outcome;Affect;Affinity;Agonist;Animal Model;Animals;Anti-Inflammatory Agents;Antioxidants;Astrocytes;Attenuated;attenuation;Behavior;Biological Assay;Blood;Brain Injuries;Brain region;Cells;Chronic;chronic pain;Clinical;Clinical Management;Cognitive deficits;combat;Consumption;cytokine;Data;Dependence;Development;Effectiveness;Enzyme-Linked Immunosorbent Assay;Epidemic;Evaluation;experience;Exposure to;functional outcomes;Generations;glial activation;Glial Differentiation;Goals;high risk;Human Resources;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;injured;Injury;Interferons;Intervention;Knowledge;Mediating;Mediator;Methods;Microglia;Military Personnel;Morphine;mu opioid receptors;Nerve Degeneration;neuroinflammation;neuropsychiatry;non-opioid analgesic;novel;Opiate Addiction;Opioid;opioid abuse;opioid exposure;opioid misuse;opioid overdose;opioid therapy;opioid use;Outcome;Oxidative Stress;Oxidative Stress Induction;Pain;Pain management;Parents;Pathway interactions;Pattern;persistent symptom;Pharmaceutical Preparations;Pharmacological Treatment;photobiomodulation;Phototherapy;Physiological;Play;prescription opioid;Prevalence;prevent;Process;Quality of life;Reactive Oxygen Species;recruit;reduce symptoms;Rehabilitation therapy;Reporting;Research Design;response;Rewards;Risk;Role;Safety;service member;Services;Signal Transduction;Slice;Substance abuse problem;symptom management;Symptoms;System;Testing;Therapeutic;Tissues;Traumatic Brain Injury;Validation;Veterans;Work

PROJECT_TITLE: Novel Intervention for TBI-induced Opioid Seeking

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Natural selection is an important evolutionary force that enables humans to adapt to new environments and fight disease-causing pathogens. However, the unique footprints of natural selection in our genome can be buried beneath those left by other evolutionary forces. Thus, by leveraging information about multiple evolutionary forces, we can identify signatures of natural selection in the human genome, and ultimately determine its role in human adaptation and disease.

PI_NAMEs: DEGIORGIO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Alleles;Area;Behavior;Communication;Complex;cost;Crotalus;Data;design;Disease;Disease Resistance;DNA sequencing;East Asian;empowerment;Environment;European;fighting;Frequencies;Genes;Genetic;Genetic Variation;Genome;genomic data;genomic variation;Genomics;Goals;Haplotypes;Historical Demography;Human;Human Genome;Image;improved;innovation;Insecta;insight;Knowledge;Left;machine learning method;machine learning model;machine learning prediction;Methodology;Methods;Modeling;Natural Selections;New York City;novel;novel strategies;Organism;pathogen;Phenotype;Plants;Population;Primates;Procedures;programs;Rattus;Research;Research Personnel;Rodent;Role;Sampling;Shapes;signal processing;Signal Transduction;Site;Snakes;statistical and machine learning;Statistical Methods;Training;Uncertainty;Variant;Venoms;Visit

PROJECT_TITLE: Identifying complex modes of adaptation from population-genomic data

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Mobility in the home and community is a key factor in determining autonomy and independence for many Veterans with disabilities (VwD). The VA provided 99,100 wheelchairs and scooters to Veterans in FY21. WARE has been collecting data from focus groups, interviews, surveys, meta-analyses, and peer-reviewed reports to generate a roadmap for the next 5 years that addresses the needs of Veterans and technology domains in need of advancement. Our roadmap is organized into 4 core activities and 4 research and development (R&D) thrusts: Health & Well-being, Living in the Community; Education & Employment; and Travel & Leisure. We propose 9 core R&D projects that address the technology domains, research thrusts, and the VA 2022-2028 Strategic Plan. VwD within the VA’s Special Disability Programs, primarily those with conditions that directly result from Military service, are the target beneficiaries of the proposed R&D.

PI_NAMEs: COOPER, RORY A. (contact);DICIANNO, BRAD E.

PROJECT_TERMS: Address;Aging;assistive robot;beneficiary;career;Caring;Communities;Data;design;Development;disability;Discipline;Education;Employment;Engineering;Environment;Focus Groups;functional improvement;Goals;Health;Healthcare Systems;Heart;Home;improved;improved mobility;industry partner;innovation;Interview;Leisures;Link;Measurable;Medical;Mentors;Meta-Analysis;military service;mobility aid;multiple disability;Multiple Trauma;next generation;Outcome;Peer Review;Personal Satisfaction;Physical Medicine;Physical therapy;Process;programs;Recommendation;rehabilitation engineering;rehabilitation research;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Scientist;Self-Help Devices;service organization;severe injury;Strategic Planning;Surveys;Survival Rate;Technology;Training;Translating;Travel;Universities;User-Computer Interface;Veterans;Voice;Wheelchairs

PROJECT_TITLE: Rehabilitation Research and Development Center for Wheelchairs and Rehabilitation Engineering

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]