NIH_SPENDING_CATS: Endocrine Disruptors

ORG_NAME: UNIVERSITY OF IOWA

PHR: NARRATIVE: Synthesis Core The Synthesis Core of the Superfund Research Program at The University of Iowa (ISRP) supports investigations of the consequences of sources and exposures to all airborne polychlorinated biphenyls (PCBs), an important class of Superfund chemicals, by providing PCB mixture, individual PCB congeners and PCB metabolites to ISRP researchers for laboratory studies and as analytical standards. The availability of authenticated test compounds in a timely and cost-efficient manner is relevant to the mandate of the Superfund Research Program because it will enable the innovative studies proposed by ISRP research projects and enhance the rigor and reproducibility of ISRP research.

PI_NAMEs: LEHMLER, HANS-JOACHIM  (contact)

PROJECT_TERMS: Acetylcysteine;Address;Animals;Catechols;Chemicals;cost efficient;Derivation procedure;Diazomethane;experience;exposed human population;Exposure to;Funding;Glucuronides;Glutathione;Goals;Guidelines;Hand;Hydroquinones;Hydroxylation;In Vitro;in vivo;Individual;innovation;Investigation;Iowa;Laboratory Study;Mammals;novel;Plants;Polychlorinated Biphenyls;Positioning Attribute;Preparation;Program Research Project Grants;programs;Quinones;Reagent;remediation;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Series;Source;Sulfate;Superfund;superfund chemical;Testing;Time;Toxic effect;Universities;Volatilization

PROJECT_TITLE: Research Support Core: Synthesis Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: VINCENT, BENJAMIN G (contact)

PROJECT_TERMS: Animal Cancer Model;anti-cancer research;B cell repertoire;B-cell receptor repertoire sequencing;Big Data;Blood;Blood Cells;Budgets;Cancer Center Support Grant;Cells;Clinical;Clinical Investigator;Clinical Research;clinical translation;Collaborations;Communities;Complement;Computer software;computing resources;cost;Coupled;Cytokine Network Pathway;Cytometry;Data;data acquisition;Data Analyses;Data Set;Dedications;DNA sequencing;Doctor of Philosophy;Educational process of instructing;Elements;Equipment;Evaluation;exome;Exons;experience;Experimental Designs;experimental study;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;genetic signature;Genomics;Goals;Haplotypes;Human;Hybrids;Immune;Immune response;immunogenic;Immunogenomics;Immunologic Monitoring;immunotherapy trials;in vivo;Infrastructure;innovative technologies;Institution;interest;Investments;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;member;Methodology;Mission;Modeling;Mus;neoantigens;new technology;Pathway Analysis;Patients;peer;Phenotype;Plasma;pre-clinical;programs;Recording of previous events;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;response;Running;Sampling;Science;Services;single cell analysis;single cell sequencing;single-cell RNA sequencing;skills;Sorting;Source;Students;System;T-Lymphocyte;Techniques;Technology;Time;Tissues;Training;tumor;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Immunogenics and Flow Cytometry

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: BIOLOGY

PHR: Project Narrative An animal cell, as a self-contained unit of life, contains all the components it needs to execute tasks like pinching in half. For example, cells possess a network of miniscule chemical motors and fibers that rearrange to generate the forces responsible for the cell shape changes. We use microscopes to gain magnified views of this dynamic network and to test how it rearranges differently if we manipulate one component at a time.

PI_NAMEs: MADDOX, AMY SHAUB (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms of cell shape change in cytokinesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Health Effects of Indoor Air Pollution;Neurosciences;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE: Project 1 – Neurotoxicity Project 1 of the Iowa Superfund Research Program will determine the extent to which human metabolites of airborne polychlorinated biphenyls (PCBs) disrupt neurotransmitter homeostasis and, ultimately, alter neurodevelopment during adolescence, a critical period for brain maturation. This outcome is relevant to public health because it will inform future risk assessment for neurotoxicity resulting from exposure to airborne PCBs and their metabolites. Therefore, the proposed research is pertinent to the goals of the Superfund Research Program to protect human health from the impact of hazardous Superfund chemicals, such as PCBs.

PROJECT_TERMS: Adolescence;Adolescent;adverse outcome;Affect;aged;Astrocytes;Attention;behavioral outcome;behavioral response;Biochemical Markers;Brain;Cell Line;Cells;Child;critical period;Data;Dopamine;dopaminergic neuron;Dose;Equilibrium;Event;executive function;Exposure to;Functional disorder;Future;Goals;Health;Homeostasis;Human;In Vitro;in vitro Model;in vivo;indoor air;Indoor Air Pollution;Indoor environment;Inhalation;Inhalation Exposure;innovation;insight;Iowa;Link;Liver;Mediating;Metabolic Biotransformation;Metabolism;metabolome;Modeling;motor control;Needs Assessment;neurobehavioral;neurochemistry;neurodevelopment;neuroinflammation;Neurons;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;neurotransmitter metabolism;Neurotransmitters;novel;Outcome;Oxidative Stress;Parents;Polychlorinated Biphenyls;Positioning Attribute;postnatal;prevent;Production;programs;Public Health;Rattus;Reactive Oxygen Species;remediation;Research;Research Project Grants;Resistance;response;Risk Assessment;Risk Factors;Rodent;School-Age Population;Schools;sex;Short-Term Memory;Site;Source;Superfund;superfund chemical;Techniques;Testing;Toxic effect;toxicant;trafficking

PROJECT_TITLE: Airborne PCBs and their Metabolites: Risk Factors for Adverse Neurodevelopmental Outcomes in Adolescence


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BEAR, JAMES E (contact)

PROJECT_TERMS: Animal Cancer Model;Animals;anti-cancer research;Area;Benchmarking;Budgets;Cancer Center;Cancer Center Support Grant;cancer therapy;Cells;Charge;confocal imaging;Confocal Microscopy;Core Facility;cost;cost effective;cost effectiveness;Cost Sharing;Drug Screening;Equipment;experience;Faculty;Funding;Geography;Grant;Hour;Human Resources;Image;Image Analysis;imaging modality;In Situ;Institution;instrument;instrumentation;intravital imaging;Investments;Journals;Laboratories;Leadership;Light;light microscopy;live cell imaging;Maintenance;Malignant Neoplasms;medical schools;Medicine;member;Microscope;Microscopy;Modality;Modeling;Modernization;Molecular;multi-photon;Nature;Needs Assessment;new technology;Organ;peer;Peer Review;programs;Publishing;Research Personnel;Resource Sharing;Resources;response;screening;Services;Source;spectrograph;Stromal Cells;Students;System;Talents;Time;Tissue imaging;Tissues;Training Activity;tumor;ultra high resolution;Visual;Visualization;Work

PROJECT_TITLE: Microscopy


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of the IMSD at UT Health San Antonio Program is to contribute to the overall diversity of the biomedical workforce in the nation. Diversity, equity, inclusion and accessibility all enhance biomedical research for the good of society. The purpose of this proposal is to provide community of students from underrepresented racial/ethnic minority groups, students with disabilities and students from disadvantaged backgrounds (UR students) pursuing doctoral degrees in biomedical research, an enriching and empowering training experience. The proposal will support a variety of activities, in a supportive and nurturing environment, to enable UR students acquire not just the knowledge and skillsets, but also the confidence to pursue successful careers in academic biomedical research as well as other careers of their choice.

PI_NAMEs: GRIFFITH, ANN VENABLES;OYAJOBI, BABATUNDE OLUKAYODE (contact);WEISS, DAVID S

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Health

PROJECT_TITLE: IMSD at UT Health San Antonio

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Digestive Diseases;Estrogen;Menopause;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE In their lifetimes, 50% of postmenopausal women sustain a fragility fracture, which commonly leads to disability, loss of independence, and even mortality; additional strategies to prevent menopause-related bone loss are sorely needed. This project postulates that: 1) a loss of gut barrier integrity (gut leak) occurs during menopause when estrogen production decreases; and 2) the consequences of gut leak, which include translocation of gut microbe-derived antigens, immune activation, and osteoclastogenesis, are associated with faster bone loss and fractures. If these hypotheses are upheld, future work could test interventions aimed at preventing a menopause-related rise in gut leak and the resulting bone loss.

PI_NAMEs: SHIEH, ALBERT  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acceleration;antagonist;Antigens;Area Under Curve;Biological Assay;Biological Response Modifiers;bone;Bone Density;bone loss;bone turnover;C-reactive protein;CD14 gene;Cell Wall;Cells;Circulation;combat;cytokine;disability;Enterocytes;Epithelial Attachment;Estrogen decline;Estrogens;Exposure to;fatty acid-binding proteins;Fracture;fragility fracture;Future;gastrointestinal epithelium;Gram-Negative Bacteria;gut microbes;Gut Mucosa;Histologic;Human;IL17 gene;Immune;immune activation;Immunologic Markers;Individual;Inflammatory;inflammatory marker;Interleukin-6;Intervention;intestinal barrier;Lead;Leaky Gut;Ligands;Lipopolysaccharides;longitudinal analysis;Longitudinal Studies;Measures;Menopause;Microbe;microbial;microbial products;microorganism antigen;mortality;mouse model;Mus;Nuclear;osteoclastogenesis;Osteoclasts;Osteoporosis;Osteoporosis prevention;outcome prediction;Participant;Pathway interactions;Perimenopause;Phenotype;phenotypic biomarker;Pilot Projects;Plasma;Postmenopause;predictive test;prevent;Production;Proteins;Publishing;receptor;Research;Sampling;Study of Women's Health Across the Nation;Testing;Time;TNF gene;Tumor Necrosis Factor Receptor;Tumor necrosis factor receptor 11b;Woman;Women's study;Work

PROJECT_TITLE: Menopause-related increase in gut leak and its relation to immune activation, bone density decline and fractures

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


PHR: PROJECT NARRATIVE: Project 2 – Metabolic Syndrome Exposure to polychlorinated biphenyls (PCBs) is associated with the development of metabolic syndrome, a cluster of conditions that includes obesity, hypertension, and disruption of glucose metabolism, which increases the risk of heart disease, stroke, and type II diabetes. The Iowa Superfund Research Program has discovered that children and adolescents are exposed to high levels of airborne PCBs in schools. Using state- of-the-art techniques, the proposed studies will define how PCBs cause metabolic syndrome through effects on adipose tissue, thus helping to define risks of PCB exposure to human health.

PI_NAMEs: KLINGELHUTZ, ALOYSIUS JOHN (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adipocytes;adipokines;Adipose tissue;Adolescent;Adolescent and Young Adult;Affect;Air;Biochemical;Biological;Biological Models;Biomimetics;Brain;cell immortalization;Cell Line;cell type;Cells;Child;Chronic;Communities;Deposition;Development;Devices;Dioxins;Dyslipidemias;Endocrine;Endocrine disruption;Endocrine Disruptors;Energy Metabolism;epidemiology study;Evaluation;exposed human population;Exposure to;Fatty acid glycerol esters;Fatty Liver;Female;Functional disorder;Gases;Genetic Transcription;glucose metabolism;glucose tolerance;Health;heart disease risk;Hepatocyte;Human;Hyperglycemia;Hypertension;Hypertrophy;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Inflammatory Response;Inhalation;innovative technologies;Insulin Resistance;interest;Iowa;lipid biosynthesis;Lipids;Liver;Male Adolescents;Metabolic syndrome;Metabolism;Methods;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organoids;Pathway interactions;Phase;Physiological;Play;Polychlorinated Biphenyls;Process;Program Research Project Grants;programs;Rattus;remediation;Research;Research Personnel;response;Risk;Risk Assessment;Role;Route;Sampling Studies;Schools;screening;Signal Pathway;Signal Recognition Particle;Signal Transduction;Site;Skeletal Muscle;Source;Stroke;subcutaneous;Superfund;System;Techniques;Technology;Testing;three dimensional cell culture;Tissues;tool;Toxic effect;Toxic Environmental Substances;Transcriptional Regulation;Visceral;Volatilization;Work

PROJECT_TITLE: The Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome


PI_NAMEs: GRAVES, LEE M (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Affinity;anti-cancer research;anti-tumor immune response;Budgets;Cancer Biology;Cancer Center Support Grant;cancer immunotherapy;Capital;cell transformation;Cells;chemoproteomics;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;Consultations;cost;cost effective;Data;data acquisition;Data Analyses;Development;discount;Drug Targeting;Epitopes;Equipment;experience;Experimental Designs;Faculty;Fractionation;Funding;Gene Expression;High Pressure Liquid Chromatography;Individual;Informatics;Infrastructure;innovation;insight;Institution;instrument;instrumentation;Investments;Kinetics;Label;Laboratories;Maintenance;Malignant Neoplasms;Manuscripts;mass spectrometer;Mass Spectrum Analysis;member;Metabolism;Methods;Modification;novel;novel therapeutic intervention;Pathway interactions;peer;Phosphotransferases;Postdoctoral Fellow;Preparation;Privatization;Protein Analysis;protein complex;protein degradation;protein protein interaction;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Recombinant Antibody;Regulation;Research;Research Personnel;Resolution;Resource Sharing;response;Sampling;Services;Signal Transduction;small molecule;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;student training;Students;Techniques;Technology;Therapeutic;Training and Education;training opportunity;tumor progression

PROJECT_TITLE: Proteomics


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE In this day and age, brain autopsy is still regarded as the gold standard and only a definite diagnostic tool for ADRDs however, available brain tissue in the US largely originates from non-Latino Whites. Despite persistent and continuous efforts, Latinos face well-documented barriers to agreeing to brain donation. The current Mentored Research Scientist Development Award (K01) project will provide the foundation for developing and implementing effective and culturally tailored educational instrument and material in an effort to increase brain donation intention to consent and participate among diverse older Latinos.

PI_NAMEs: MORLETT PAREDES, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Age;Aging;Agreement;Altruism;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attitude;Autopsy;Belief;Brain;brain tissue;California;career;career development;Chicago;Cognitive;cohort;Communities;community engagement;Complex;Consent;Data;Dementia;design;Development;Diagnosis;diagnostic tool;Dimensions;Disparity;Education;education research;Educational Materials;Enrollment;Ensure;Etiology;Face;Focus Groups;Foundations;Funding;Goals;Health;High Prevalence;improved;Infrastructure;insight;instrument;Intention;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Lead;Measures;Mediating;Mentored Research Scientist Development Award;Mentors;Methods;Minority;Modeling;Neurocognitive;neuropathology;Neurosciences;optimism;Organ Donations;Participant;Pathology;Pathway interactions;Perception;Persons;Pilot Projects;pilot test;Population;Populations at Risk;post intervention;Postdoctoral Fellow;Procedures;Process;Productivity;programs;Publications;Questionnaires;recruit;Religious Belief;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Sample Size;Scientist;skills;social culture;Study of Latinos;Surveys;symposium;Techniques;Time;Training;Trust;Underserved Population;Universities

PROJECT_TITLE: Pathways to enrolling diverse Latinos in autopsy studies: Insights from a largelongitudinal study

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Nutrition;Pediatric;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE: Project 3 – The AESOP Study The Iowa Superfund Research Program’s AESOP Study (Project 3) is a community-based research study to assess personal inhalation and dietary exposures to polychlorinated biphenyls (PCBs) arising from legacy and non-legacy environmental pollution and indoor air contamination among adolescent children and their mothers in one urban and two rural diverse communities. Questionnaire data, blood levels of PCB congeners and metabolites, and early biomarkers of toxicity will be analyzed to support our physiologically-based pharmacokinetic modeling and to evaluate our hypothesis that inhalation is the dominant route of PCB exposure for school children. Individual data will be reported back to study subjects while summary data will be reported to the communities, EPA, and other stakeholders.

PI_NAMEs: THORNE, PETER S (contact)

PROJECT_TERMS: absorption;Accounting;Adolescence;Adolescent;Air;American;Area;Back;Behavioral;bilingualism;biobank;Biological Markers;Biological Monitoring;Blood;Body Burden;Breast Feeding;Breathing;building materials;Chicago;Child;Chronic;cohort;Cohort Studies;Collaborations;Communities;community advisory board;community based participatory research;community based research;community engagement;computerized tools;Coupled;Data;Data Aggregation;data de-identification;design;Diet;dietary;Dietary Assessment;Dietary intake;DNA;Dose;Drug Kinetics;early detection biomarkers;Eating;Enrollment;Environment;Environmental Health;Environmental Pollution;ethnic diversity;Excretory function;experience;exposure route;Exposure to;Family Study;Food;food consumption;Freedom;Functional disorder;Funding;Health;health data;Health Status;Home;Hormones;Human;Indiana;Individual;Indoor Air Pollution;indoor concentrations;Inflammation;Inhalation;Inhalation Exposure;Inhalation Toxicology;innovation;insight;Iowa;Life Cycle Stages;Link;Location;Measurement;Measures;Metabolic syndrome;Metabolism;Midwestern United States;Modeling;models and simulation;Mothers;nanofiber;National Health Interview Survey;neurobehavioral;novel;Occupational;Oral;Outcome;Oxidative Stress;Participant;Perinatal Exposure;pharmacokinetic model;Physiological;physiologically based pharmacokinetics;placental transfer;Policies;pollutant;Polychlorinated Biphenyls;potential biomarker;predictive modeling;Production;programs;Questionnaires;racial diversity;recruit;remediation;Reporting;Research;research study;Resources;Risk;Risk Assessment;Risk Estimate;Risk Factors;Role;Route;Rural;Sampling;Schools;Serum;Source;Study Subject;Superfund;superfund chemical;Surveys;Testing;Thyroid Hormones;Time;Toxic effect;Uncertainty;uptake;Urine;Volatilization;wearable device

PROJECT_TITLE: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: SONDEK, JOHN E (contact)

PROJECT_TERMS: Area;Biochemical;Bioinformatics;Biological;Biological Process;Biomolecular Nuclear Magnetic Resonance;biophysical properties;Biophysics;Budgets;Cancer Biology;Cancer Center Support Grant;Cells;Chemicals;Complex;Computer software;computing resources;Cryoelectron Microscopy;Discipline;Doctor of Philosophy;drug discovery;Education;Educational process of instructing;Ensure;Environment;experience;Faculty;Funding;Grant;Infrastructure;Institution;instrumentation;Isotopes;Label;Ligands;macromolecule;member;Membrane;Methods;Mission;Molecular;molecular dynamics;Molecular Structure;Multidimensional NMR Techniques;NMR Spectroscopy;outreach;particle;peer;Peptide Synthesis;peptidomimetics;pre-clinical;professor;Property;protein complex;protein expression;protein purification;Proteins;Research;Research Assistant;Research Personnel;Resource Sharing;Resources;Services;Site;Source;Strategic Planning;structural biology;synergism;synthetic peptide;System;Therapeutic;Training;user-friendly;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TAMPA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is relevant to public heath because the prevalence of dementia is increasing rapidly and is the most expensive medical condition. The proposed research will determine the efficacy of computerized cognitive training to reduce incidence of mild cognitive impairment and dementia. Thus, the proposed research is relevant to NIH's mission to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: O'BRIEN, JENNIFER LEE (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: active control;active control group;Activities of Daily Living;Address;Administrator;Advertisements;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;amyloid pathology;Apolipoprotein E;apolipoprotein E-4;arm;Attenuated;bilingualism;Categories;Certification;Classification;Clinical;Clinical assessments;clinical diagnosis;clinical practice;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive function;cognitive training;Communities;computer game;computerized;Control Groups;cost;Critiques;Data;Dementia;dementia risk;Diagnosis;Diagnostic;disability;Disease;Drops;Education;effective intervention;Effectiveness;effectiveness testing;efficacy evaluation;Elderly;Enrollment;Evaluation;Exhibits;Experimental Designs;Failure;functional decline;Funding;genetic analysis;genetic testing;Genotype;Goals;Health;Impaired cognition;implementation facilitation;improved;Incidence;innovation;Institutional Review Boards;instrumental activity of daily living;Intervention;Knowledge;Life;Location;Marketing;Measurement;Media Campaign;Medical;Memory;mild cognitive impairment;Minority Recruitment;Mission;Monitor;Neuropsychological Tests;Neuropsychology;Nonpharmacologic Therapy;older adult;Outcome;Participant;participant enrollment;Personal Satisfaction;Phase;Population;Positron-Emission Tomography;Prevalence;prevent;Prevention;Prevention trial;Preventive;primary endpoint;processing speed;Protocols documentation;Public Health;Randomized;randomized, clinical trials;recruit;Reporting;Research;Research Design;Research Personnel;Risk Reduction;Safety;Sampling;screening;social media;Spanish;Telephone;Testing;theories;Time;Training;Training Programs;Translations;treatment arm;trial design;United States National Institutes of Health;Visit;web page;β-amyloid burden

PROJECT_TITLE: Cognitive training to reduce incidence of cognitive impairment in older adults


NIH_SPENDING_CATS: Endocrine Disruptors;Health Effects of Indoor Air Pollution

PHR: NARRATIVE: Project 4 – Sources of Airborne PCBs The Iowa Superfund Research Program’s Project 4 addresses the problem of airborne PCBs in schools, in homes, and in communities near PCB-contaminated water. Researchers will identify specific sources of PCBs and the factors that cause these sources to release PCBs. Project 4 will provide essential and currently unavailable data and information needed to prioritize removal of these sources.

PI_NAMEs: HORNBUCKLE, KERI C (contact)

PROJECT_TERMS: Address;Adult;Air;air sampling;building materials;Calibration;Categories;chemical property;Child;Collaborations;Color;Communication;Communities;community collaboration;community engagement;community partners;consumer product;contaminated sediment;contaminated water;cost effective;Data;Data Analyses;data management;design;detection method;Diet;Environment;Environmental Protection;Equipment and supply inventories;Event;Excision;Exhibits;exposed human population;Exposure to;Fishes;Freedom;Gases;Goals;Hazard Assessment;Home;improved;indoor air;indoor concentrations;Inhalation;Inhalation Exposure;Iowa;Laboratories;laboratory experiment;Light;Liquid substance;manufacture;manufacturing process;Maps;Measurement;Measures;Methods;Modeling;Monitor;nanofiber;Neighborhoods;novel;novel strategies;Outcome;Persons;Phase;Physical Function;Pigments;Polychlorinated Biphenyls;Polymers;Population;Program Research Project Grants;Property;Reagent;remediation;Reproducibility;Research;Research Personnel;Risk;Role;Sampling;Schools;Signal Recognition Particle;Site;Source;Superfund;superfund chemical;superfund site;Surface;teacher;Techniques;Testing;Time;Toxic effect;Uncertainty;uptake;urban area;Vulnerable Populations;Water

PROJECT_TITLE: Sources of Airborne PCB Congeners


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Telemedicine for the treatment of mental illness (or “telemental health”) is one way to improve access to mental health care for those who need it. Use of telemental health dramatically increased during the COVID-19 pandemic. In this renewal, we will study the period after the public health emergency ends to assess how different state laws and regulations influence the use of telemental health, whether increased use of telemental health has increased access for disadvantaged minorities and rural patients, how telemental health is being used in care, and whether its use is associated with improved quality of care.

PI_NAMEs: HUSKAMP, HAIDEN A. (contact);MEHROTRA, ATEEV

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: access disparities;Address;Area;barrier to care;Bipolar I;Caring;Categories;Chronic;Clinical;clinical care;clinical practice;Communities;Congresses;COVID-19;COVID-19 pandemic;Data;Diffusion;digital divide;Dimensions;Disadvantaged minority;Disease;Disparity;Disparity population;disparity reduction;Emergency department visit;Equipment and supply inventories;Equity;experience;Face;Family member;Federal Government;Foundations;Future;Growth;health care delivery;health care disparity;health plan;Health Policy;health practice;Hospitalization;Improve Access;improved;Individual;innovation;Insurance;Insurance Carriers;Insurance Claim Review;insurance claims;interest;Interview;Laws;Licensure;long-standing disparities;machine learning method;Major Depressive Disorder;Measures;Medicaid;Medicare;medication compliance;Mental disorders;Mental Health;Mental Health Services;Methods;minority patient;Modeling;National Institute of Mental Health;Outcome;pandemic disease;Paper;parity;Patients;Pattern;Patterns of Care;payment;Perception;Persons;Play;Policies;Policy Maker;Privatization;programs;Provider;public health emergency;Publishing;Quality of Care;Recording of previous events;Regulation;response;Role;Rural;rural area;Rural Community;rural disparities;rural patients;Severities;Specialist;State Government;Technology;telehealth;Telemedicine;Telemental;Telephone;treatment disparity;underserved community;uptake;Variant;Visit;Work

PROJECT_TITLE: Use of Telemedicine in the Treatment of Mental Illness


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PEROU, CHARLES M (contact)

PROJECT_TERMS: analytical method;analytical tool;anti-cancer research;Basic Science;Big Data;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;Biological Specimen Banks;Budgets;Cancer Center;Cancer Center Support Grant;Clinical;clinical care;Clinical Research;Complement;computer infrastructure;cost;Data Analyses;Data Analytics;data management;data repository;data sharing;Data Storage and Retrieval;data warehouse;Databases;Development;DNA;Environment;Faculty;Foundations;fundamental research;Generations;Genomics;Healthcare;Human Resources;Individual;Infrastructure;Institution;integration site;International;Investments;Laboratories;Life;Maintenance;Management Information Systems;Medical;member;Methods;operation;Output;Paper;patient registry;peer;Process;Protocols documentation;Publications;Publishing;Reporting;Research;Resource Sharing;Resources;RNA;Sampling;Secure;Services;software development;Source;success;support network;Systems Development;Techniques;The Cancer Genome Atlas;Tissues;tool;Translational Research;Wages

PROJECT_TITLE: Bioinformatics


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The goal of this project is to conduct a Hybrid Type I effectiveness-implementation randomized controlled trial of Project nGage, an evidence-based, flexible, and tailored intervention designed to harness social network support to improve retention in care and viral suppression for HIV-positive young Black MSM (YBMSM) age 18-35. The study will be conducted in Chicago, IL and Alabama, two sites prioritized in the national Ending the HIV Epidemic Plan. Project nGage holds remarkable potential for improving Continuum of Care outcomes through its novel focus on recruiting, informing, and motivating naturally existing social support network members and, thus, benefitting public health by decreasing the risk of onwards HIV transmission and increasing the number of YBMSM retained in HIV care.

PI_NAMEs: BATEY, DAVID S.;BOURIS, ALIDA M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Age;aged;AIDS prevention;Alabama;Anti-Retroviral Agents;Area;behavior change;Behavioral;Behavioral Sciences;black men;black men who have sex with men;care outcomes;Caring;Case Management;Case Manager;Characteristics;Chicago;Clinic;Clinical;Communities;Computerized Medical Record;Consolidated Framework for Implementation Research;Continuity of Patient Care;cooking;County;Coupled;Data;Data Collection;Deep South;Effectiveness;effectiveness testing;effectiveness-implementation RCT;effectiveness/implementation trial;Emotional;Enrollment;Ensure;Epidemic;epidemic preparedness;Evaluation;evidence base;Evidence based intervention;Expectancy;experience;flexibility;Focus Groups;Foundations;Geography;Goals;Health;health disparity;HIV;HIV Seropositivity;Hybrids;implementation cost;implementation evaluation;implementation science;implementation strategy;improved;improved outcome;Incidence;indexing;innovation;Intervention;intervention effect;Life;Link;Maintenance;Measures;Mediating;member;men;Mental Health;Modeling;Monitor;Motivation;novel;Outcome;peer;Persons;Positioning Attribute;post intervention;primary outcome;Process;programs;Public Health;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;recruit;Research;response;Risk;Role;Self Efficacy;Services;Site;skills;social engagement;Social Network;social stigma;Social support;stressor;Substance abuse problem;substance use;substance use treatment;Support Groups;Surveys;Testing;Theoretical model;theories;therapy design;transmission process;treatment as prevention;treatment as usual;Viral;Viral Load result;Visit;Visualization

PROJECT_TITLE: Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;Infectious Diseases;Lung;Neurosciences;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative/Relevance: Streptococcus pneumoniae, the leading cause of pneumonia, sepsis, and meningitis worldwide, is a model for determining the mechanisms of lethal inflammation and injury in the brain. While the cell wall drives tissue injury in the postnatal setting, it appears to do the opposite in the fetus. New data suggests that cell wall crosses from the maternal circulation to fetus and induces neuroproliferation, abnormal brain architecture and longterm abnormal behavior. Understanding this switch from cell death to promoting cell proliferation will reveal new innate immune biology and inform efforts to develop neuroprotective treatments. It will also link the innate immune receptor TLR2 to neurodevelopment.

PI_NAMEs: TUOMANEN, ELAINE I (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Affect;Amyloid;Anatomy;Animal Model;Architecture;Area;Autophagocytosis;Bacteria;Behavior;Binding;Biochemical;Biology;Birth;Blood Circulation;Brain;brain abnormalities;Cell Communication;Cell Cycle Kinetics;Cell Death;Cell Proliferation;Cell surface;cell type;Cell Wall;Cells;Cilia;Circulation;cognitive function;Data;Defect;Development;Dimensions;Drosophila genus;Embryo;Equilibrium;Evolution;Excision;experimental study;Exposure to;fetal;Fetus;fly;forkhead protein;FOXG1B gene;Functional disorder;Gram-Positive Bacterial Infections;Homeostasis;Human;Immune;Immune signaling;Immunologic Receptors;in utero;Individual;Induced Neurons;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;innovation;knockout animal;Link;Measures;Medical;Meningitis;model organism;Modeling;Modification;Molecular;Morphogenesis;morphogens;mouse model;Mus;Natural Immunity;neurodevelopment;neurogenesis;Neurons;Neuropathogenesis;neuroprotection;novel;Nuclear;Organ;Organoids;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pattern;Placenta;Pneumonia;postnatal;postnatal neuronal death;pregnant;programs;Publications;pup;receptor recycling;Recycling;Regulation;response;Role;Sensory;Sepsis;Shapes;SHH gene;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sonic Hedgehog Pathway;Streptococcus pneumoniae;Structure;Subcellular Anatomy;Testing;Time;tissue injury;TLR2 gene;trafficking;transcription factor;transcriptome sequencing;Work

PROJECT_TITLE: Bioactivities of pneumococcal cell wall in neuropathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


PHR: NARRATIVE: Project 5 – Remediation in Sediments Project 5 of the Iowa Superfund Research Program will develop and optimize novel sorptive and reactive black carbon materials and test them as delivery vehicles for aerobic PCB-degrading microorganisms under environmentally relevant conditions (e.g., low and variable dissolved oxygen concentrations, and variable salinity and temperature). We will demonstrate that the best performing combinations of black carbon materials and microorganisms can effectively decrease airborne PCB emissions from contaminated sediments and thus lessen human exposure to PCBs by inhalation in communities located near Superfund sites. Therefore, the proposed research is pertinent to the goals of the Superfund Research Program by developing advanced methods to reduce the amount and toxicity of PCBs in the environment.

PI_NAMEs: MATTES, TIMOTHY E. (contact)

PROJECT_TERMS: Address;Aerobic;Air;Area;Atmosphere;Bacteria;Biodegradation;Biological Process;Biotechnology;Carbon Black;Chemicals;Chlorine;Communities;community partners;contaminated sediment;Coupled;Data;data management;delivery vehicle;Development;disease registry;Economics;efficacy evaluation;Environment;Environmental Engineering technology;Environmental Science;Excision;experience;exposed human population;Exposure to;fungus;Goals;Health;Human;improved;Individual;Industrialization;Inhalation;innovation;Iowa;Laboratories;manufacturing scale-up;Measures;Methods;Microbe;microbial;Microbial Biofilms;microorganism;Molecular;novel;Organic Chemicals;Outcome;Oxygen;Performance;Poison;pollutant;Polychlorinated Biphenyls;Population;Predisposition;prevent;Process;Production;Program Research Project Grants;programs;Property;remediation;Research;Resources;Risk;Sampling;Sampling Studies;scale up;Soil;Source;source localization;Superfund;superfund site;Technology Transfer;Temperature;Testing;tool;Toxic effect;Universities;Volatilization;Water;Work

PROJECT_TITLE: Mitigating Airborne PCB Emissions from Sediments with Black Carbon Materials and PCB-Degrading Biofilms


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MONTGOMERY, STEPHANIE  (contact)

PROJECT_TERMS: Algorithm Design;Animals;anti-cancer research;Archives;Basic Science;Biological Assay;Biological Markers;Blood;Board Certification;Budgets;Cancer and Nutrition;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Model;Clinical;clinical investigation;Clinical Research;Clinical Trials;Consultations;cost;digital;digital imaging;digital pathology;Doctor of Philosophy;Epitopes;experimental analysis;Experimental Designs;Faculty;Formalin;Funding;gene therapy;Generations;Health Service Area;Histologic;histological stains;Histological Techniques;Histology;Histopathology;Hospitals;Human;human tissue;Image;Immunofluorescence Immunologic;Immunohistochemistry;Immunotherapy;In Situ Hybridization;Informatics;Institution;instrumentation;Journals;Laboratories;Location;Malignant Neoplasms;Medicine;member;Molecular;Morphology;nano-string;Nanotechnology;Nature;new technology;novel;operation;Paraffin Embedding;Pathologist;Pathology;peer;Peer Review;personalized medicine;Population Study;pre-clinical;Preparation;Publications;Publishing;Research;Research Design;Research Personnel;Resource Sharing;RNA;Science;Services;Signal Transduction;single cell analysis;Sister;Site;Slide;Source;Specimen;Specimen Handling;Surgical Pathology;Techniques;Technology;Therapeutic;Tissue Embedding;Tissue Engineering;Tissue Microarray;Tissue Procurements;Tissue Stains;Tissues;Training Programs;translational scientist;Translations;tumor microenvironment;Universities;Urinalysis;Veterinary Pathology;Veterinary Schools;Work

PROJECT_TITLE: Translational Pathology


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030, due in part to its immunosuppressive tumor microenvironment which limits the efficacy of novel immunotherapies. We have found that loss of the epigenetic regulator DNA methyltransferase I (DNMT1) in pancreatic tumor cells leads to a decrease in tumor growth along with an increase in anti-tumor immune infiltration into tumors. Based on these findings, I propose to investigate the mechanisms by which DNMT1 regulates the tumor immune microenvironment and its potential as a novel therapeutic target for combination immunotherapy to treat pancreatic cancer.

PI_NAMEs: HOLLANDER, ERIN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Azacitidine;Biological Assay;bisulfite sequencing;Cancer Etiology;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cell Survival;Cells;Cessation of life;Clone Cells;Coculture Techniques;Combination immunotherapy;comparative efficacy;CRISPR screen;Data;derepression;DNA biosynthesis;DNA Methylation;DNA methyltransferase inhibition;DNA Modification Methylases;Double-Stranded RNA;Early Diagnosis;effective therapy;effector T cell;Elements;Endogenous Retroviruses;Epigenetic Process;experimental study;Exposure to;Flow Cytometry;gene repression;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;Goals;Growth;Immune;immune cell infiltrate;immune checkpoint blockade;Immune system;Immunocompetent;immunoregulation;Immunosuppression;Immunotherapy;immunotherapy trials;in vivo;Infiltration;inhibitor;Injections;insight;Knock-out;KPC model;Libraries;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Methylation;methylation pattern;mimicry;mouse model;Mus;neoplastic cell;new therapeutic target;novel;overexpression;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Phenotype;Primary Neoplasm;Refractory;Regimen;release factor;Reporting;Resistance;response;Role;sensor;subcutaneous;Survival Rate;T cell infiltration;T-Cell Activation;T-Cell Depletion;T-cell inflamed;T-Lymphocyte;Therapeutic;therapeutic target;tool;transcriptome sequencing;translational potential;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Suppression;tumor-immune system interactions;Tumor-infiltrating immune cells;United States;Viral;Virus Activation;Western Blotting

PROJECT_TITLE: Identifying the Role of Tumor Cell Intrinsic DNMT1 in Anti-Tumor Immunity in Pancreatic Ductal Adenocarcinoma


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Services;Infectious Diseases;Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Infections and antimicrobial resistance are common in older adults and commonly lead to poor outcomes. The overarching goal of this proposal is to train the next generation of multidisciplinary researchers who will advance the field of infection prevention in older adults and make healthcare safer. We expect our results to shift the evolving paradigm of infection control and prevention in long-term care institutions and hospitals through designing effective, efficient, and targeted infection control programs for frail older adults.

PI_NAMEs: MODY, LONA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accounting;Acute;acute care;Admission activity;adverse outcome;Aging;aging population;Antibiotic Therapy;antimicrobial;Antimicrobial Resistance;Applications Grants;Area;Bacterial Infections;Capsicum;Cardiovascular Diseases;career;Career Choice;career development;career life balance;Caring;Clinical;clinical diagnostics;clinical practice;Cognitive;cohort;Collaborations;Communicable Diseases;community based participatory research;comorbidity;COVID-19 mortality;COVID-19 survivors;data repository;Data Set;Databases;Dedications;design;detection method;Development;Diabetes Mellitus;Diagnostic;disability;Discipline of Nursing;Education;Environment;Environmental Pollution;Epidemiology;Event;evidence base;Face;Faculty;Foundations;Frail Elderly;Funding;Geriatrics;Goals;Grant;Guidelines;Health;Health Care Costs;health care delivery;Health Professional;Healthcare;Healthcare Systems;healthcare-associated infections;High Prevalence;high risk;Hospitals;improved outcome;indexing;Individual;Infection;Infection Control;infection management;Infection prevention;innovation;Institution;Insurance;Integration Host Factors;Internal Medicine;International;Intervention;Intervention Studies;K-Series Research Career Programs;Lead;Length of Stay;Life;Link;Long-Term Care;Measures;Medicaid;medical appointment;medical schools;Medicare;Medicine;meetings;Mentors;Mentorship;Metadata;Michigan;Microbe;Microbiology;microbiome;Modeling;Molecular Epidemiology;Movement;multi-drug resistant pathogen;multidisciplinary;next generation;Nose;novel;Nursing Homes;Obesity;older adult;Older Population;Operative Surgical Procedures;Outcome;Outcomes Research;Paper;pathogen;pathogenic bacteria;pathogenic virus;Patient Care;patient oriented research;patient safety;Patients;Patients' Rooms;Persons;Pharyngeal structure;Population;Positioning Attribute;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Precision Health;Predisposition;Prevention program;Privatization;professor;programs;Public Health Schools;Publications;Publishing;Quality of Care;Randomized;rapid technique;Recreation;Research;Research Personnel;research study;Resistance to infection;Resources;respiratory;Respiratory Tract Infections;response;Risk;risk minimization;Role;Safety;Sampling;SARS-CoV-2 infection history;Scholarship;Shapes;Stream;Structure;System;systemic barrier;tenure track;Testing;Training;Training Programs;Translational Research;transmission process;Unemployment;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Variant;Viral;viral transmission;Virus Diseases;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE The Administrative Core housed at the Harvard T.H. Chan School of Public Health and representative of all participating institutions will organize the intellectual activities of the Superfund Research Center (SRC). The Core’s major responsibilities are to oversee the scientific progress and integration of SRC components, including successful mentoring of trainees, fostering communication between the SRC and diverse stakeholders, providing fiscal oversight, carrying out research translation, and ensuring compliance with NIH requirements for data and resource sharing and protection of human subjects. By providing an infrastructure that facilitates communication and integration across all SRC components, the Administrative Core will serve as a central focal point to reinforce our overall goal of improving public health and decision-making at Superfund sites through the pursuit of multidisciplinary, integrative research and training.

PI_NAMEs: LU, QUAN  (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Animals;Climate;Cognition;Cognitive;Cognitive aging;Collaborations;Communication;community center;Complex Mixtures;Computational Science;Data;Data Science;data sharing;Decision Making;design;Detection;direct application;early life exposure;Emergency response;Ensure;Environmental Engineering technology;Environmental Epidemiology;Environmental Health;Environmental Protection;Environmental Science;Faculty;Fostering;Future;Genetic;global environment;Goals;Government Agencies;graduate student;Hazardous Substances;Health;Human;human subject;human subject protection;improved;Information Dissemination;Infrastructure;insight;Institution;Institutional Review Boards;Interdisciplinary Communication;Interdisciplinary Study;late life;Leadership;Life;Massachusetts;meetings;member;Mentors;Metal exposure;Metals;Mission;Modeling;Molecular Genetics;Molecular Toxicology;multidisciplinary;Neurobiology;Newsletter;podcast;Policy Maker;Postdoctoral Fellow;programs;Public Health;Public Health Schools;remediation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Science;Scientist;Series;social media;Source;Superfund;superfund site;symposium;Technology;technology development;Technology Transfer;Time;tool;Toxicology;Training;Translating;translational approach;translational potential;Translational Research;United States National Institutes of Health;Universities;Visit;web site;Work;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Completion of the proposed study is an important first step in understanding how specific human milk oligosaccharides (HMOs) that are unique to mother’s milk, shape early brain and cognitive development in normal birth weight and low birth weight infants, at elevated risk for cognitive deficits. Results will provide data and support to develop efficient and effective clinical trials, with future implications to validate the roles of HMOs that may have positive effects on early brain and cognitive development.

PI_NAMEs: BERGER, PAIGE KIMBERLY (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adult;Affect;Anatomy;Animals;Applied Skills;Area;Attention;Betula Genus;Birth Weight;Body Composition;Brain;Brain Injuries;brain magnetic resonance imaging;Breast Feeding;Breastfed infant;California;Carbohydrates;career;Child;Clinical Nutrition;Clinical Trials;Cognition;Cognitive deficits;cognitive development;cognitive enhancement;Complex;Data;Development;dietary;Diffusion Magnetic Resonance Imaging;Exclusive Breastfeeding;Exposure to;Feasibility Studies;feeding;Fermentation;Fostering;Foundations;Funding;Future;Goals;gray matter;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;high risk infant;high risk population;Hispanic;Human Milk;human milk oligosaccharides;Impaired cognition;Infant;Inflammation;Lead;Learning Skill;Life;Los Angeles;Low Birth Weight Infant;Magnetic Resonance Imaging;Measures;Memory;Mentors;Mothers;MRI Scans;myelination;neuropsychiatric disorder;Nutritional;Nutritional Study;Oligosaccharides;Outcome;Outcome Measure;Parents;Pediatric Hospitals;Phase;Population;post-doctoral training;prebiotics;Premature Infant;Process;recruit;Research;Resources;Risk;Role;Shapes;Sialic Acids;Signal Transduction;skill acquisition;skills;Source;Structure;Techniques;Training;United States National Institutes of Health;Universities;white matter;Work

PROJECT_TITLE: Role of Human Milk Oligosaccharides on Brain Development in Preterm Infants

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: JONES, CORBIN D (contact)

PROJECT_TERMS: Basic Science;Bioinformatics;Biological Assay;Biological Sciences;Budgets;Cancer Center Support Grant;cancer genetics;cancer genomics;cancer predisposition;Cancer Research Project;cancer type;Cell Physiology;Center for Translational Science Activities;Clinical;Clinical Pathways;clinical translation;Clinical Trials;Collaborations;Computer Analysis;computer infrastructure;Consultations;Data;data sharing;design;Detection;digital;DNA Resequencing;Education;Environment;epidemiology study;Equipment;experience;Faculty;Future;Generations;Genome;genome sequencing;Genomics;Genomics Shared Resource;Genotype;Glean;Heritability;Infrastructure;Institution;instrumentation;Intake;Investments;Knowledge;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;member;Molecular;Molecular Epidemiology;Molecular Genetics;nano-string;nanopore;National Clinical Trials Network;next generation;North Carolina;Pathologist;Patient Care;Patients;peer;Population Study;Precision Medicine Initiative;Preparation;Primary Neoplasm;Process;Production;Protocols documentation;public database;Publications;Records;Repetitive Sequence;Reproducibility;Research;Research Personnel;RNA;RNA interference screen;Sampling;Services;Source;Specimen;System;Technical Expertise;Technology;technology platform;Tennessee;Testing;The Cancer Genome Atlas;transcriptome;transcriptome sequencing;transcriptomics;translational cancer research;translational genomics;translational study;treatment arm;tumor;Universities;Validation;Variant;whole genome

PROJECT_TITLE: Sequencing and Genomics


NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE The Data Management and Analysis Core (DMAC) will provide data management, biostatistical, bioinformatics, and geographical information system (GIS) support and ensure resource sharing and reproducible science for all four projects and all cores supported by the program. In addition to this support, core faculty and researchers will engage in mission-related research that will develop methods to integrate high dimensional exposure, molecular, and phenotypic data and train Superfund investigators in best practices for data management and analysis. Through its activities, DMAC will foster and enable the interoperability of data and methods between the Center’s biomedical and environmental science and engineering projects as well as between this Center and the broader scientific community, accelerating the impact of the Center's research.

PI_NAMEs: COULL, BRENT ANDREW (contact)

PROJECT_TERMS: Acceleration;Algorithms;Area;Bioinformatics;Biometry;Case Study;Code;Cognitive aging;Collaborations;Communities;community engagement;Complex;Computer software;computerized data processing;computerized tools;Core Facility;Data;Data Analyses;Data Commons;data infrastructure;data interoperability;data management;Data Science;data sharing networks;database of Genotypes and Phenotypes;design;Development;Ensure;Environmental Engineering technology;Environmental Health;Environmental Science;Faculty;FAIR principles;Fostering;Generations;Genetic;genome sciences;genome-wide;genomic data;Genomics;Geographic Information Systems;graduate student;high dimensionality;Image;Infrastructure;Internet;meetings;member;Metals;Methodology;Methods;Mission;Molecular;next generation;open data;Phase;Phenotype;phenotypic data;Postdoctoral Fellow;pre-doctoral;Procedures;programs;Protocols documentation;Public Health Schools;quality assurance;Quality Control;remediation;Reproducibility;Research;Research Methodology;Research Personnel;Resource Sharing;Resources;Science;Scientist;Services;skills;sound;Source;Specific qualifier value;Standardization;Statistical Computing;Statistical Methods;Statistical Models;statistics;Strategic Planning;student training;Students;success;Superfund;Support System;Teacher Professional Development;Testing;Training;Training and Education;Translating;Translational Research;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Kidney Disease

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Inhibition of sodium-glucose cotransporter 2 (SGLT2) reduces diabetic glomerular hyperfiltration and protects the diabetic kidney by increasing the macula densa NaCl delivery and thus enhancing the tubuloglomerular feedback (TGF) response. However, inhibition of SGLT2 also increases glucose delivery to the macula densa, which is expected to decrease the TGF response through the macula densa sodium-glucose cotransporter 1 (SGLT1) - neuronal nitric oxide synthase (NOS1) - TGF pathway, and thereby limit both the GFR-lowering effect of SGLT2 inhibition and its protective effects on the diabetic kidney. This project aims to determine the role of the macula densa SGLT1-NOS1-TGF pathway in response to SGLT2 inhibition, with hopes that findings from this study will provide supportive and mechanistic evidence for the use of combined SGLT2 and SGLT1 inhibition in the treatment of diabetic kidney disease.

PI_NAMEs: ZHANG, JIE  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: absorption;Address;Anti-diabetic Drugs;Apical;arteriole;Attenuated;Blood Glucose;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;Excretory function;FDA approved;Feedback;fluorescence imaging;Generations;Glomerular Filtration Rate;Glucose;Hyperglycemia;In Vitro;in vivo;inhibitor;Injury to Kidney;Juxtaglomerular Apparatus;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Macula densa;Measurement;Mediating;Micropuncture;mouse model;Nephrons;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;novel;Pathway interactions;Perfusion;protective effect;response;Risk Factors;Role;Sodium;symporter;Techniques;Testing;Transgenic Mice;Tubular formation

PROJECT_TITLE: Significance of Tubuloglomerular Feedback in SGLT1 and SGLT2 Inhibition in Diabetic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Patient Safety

PI_NAMEs: BENNETT, ANTONIA  (contact)

PROJECT_TERMS: Accelerometer;anti-cancer research;Area;Award;Behavior Therapy;behavioral study;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control Research;Caring;Clinical;clinical care;Clinical Trials;Common Terminology Criteria for Adverse Events;comparative effectiveness;Complex;Computer software;Consultations;Continuity of Patient Care;Contracts;Data;Data Analyses;design;Development;electronic data;Explosion;Faculty;fitbit;flexibility;Foundations;Grant;Health behavior;health management;Health Policy;Hospitals;implementation evaluation;innovation;Institution;interest;Intervention;K-Series Research Career Programs;Leadership;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;member;Methodology;Methods;mid-career faculty;multi-site trial;neoplasm resource;novel therapeutics;Oncology;Opioid;Outcomes Research;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;peer;Personal Satisfaction;Postoperative Period;Quality of Care;Quality of life;Registries;Research;Research Design;Research Institute;Research Personnel;research study;Resource Sharing;Resources;response;Site;skills;Source;study population;Surveys;Symptoms;System;tool;Treatment outcome;trend;United States National Institutes of Health;Universities;Validation;Vertebral column;wearable device

PROJECT_TITLE: PRO-Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

PHR: NARRATIVE Communities that are exposed to metals often have limited resources, partnerships, and scientific knowledge on adverse health effects nor means to reduce or mitigate exposure. The goal of the Community Engagement Core is to use an approach based on bi-directional communication, citizen science, and co-development and implementation of an intervention to remediate metals exposures to reduce exposure in Superfund affected communities. We will work with local residents and stakeholders in Roxbury, Massachusetts and San Luis Valley, Colorado to: (1) identify concerns regarding exposures to toxic metals; (2) collaboratively collect and assess individual metal and metal mixture levels from drinking water, soil, urine, and toenail samples; and (3) co-implement a remediation intervention by using commercially available water filters to reduce metals mixtures exposures.

PI_NAMEs: JAMES-TODD, TAMARRA M (contact)

PROJECT_TERMS: 13 year old;Address;Advocate;Affect;Area;Arsenic;Back;Basic Science;Biological;Boston;Cadmium;Caring;Child;Childhood;Chromium;citizen science;Cognitive;Cognitive aging;Colorado;Commodore;Communication;Communities;community collaboration;community empowerment;community engagement;Community Health Aides;Community Participation;community partners;community partnership;contaminated water;Copper;cost;cost effective;Coupled;Data;drinking water;early life exposure;Education;effectiveness testing;Engineering;Ensure;Environment;Epidemiology;Ethnic Origin;Evaluation;exposure pathway;Exposure to;Foundations;Geographic Locations;Goals;ground water;Hazardous Substances;Health;Health Personnel;Household;Human;implementation intervention;Individual;Industrialization;innovation;innovative technologies;Instruction;Intervention;Knowledge;late life;Lead;Life;Low income;Low Income Population;Manganese;Massachusetts;Maternal and Child Health;Measures;member;Metal exposure;Metals;Methods;Mission;Neighborhood Health Center;Neighborhoods;novel;offspring;Parents;Participant;Population;Poverty;Pregnancy;pregnant;Pregnant Women;prenatal exposure;Privatization;Problem Solving;Productivity;Provider;Public Policy;Race;remediation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;risk mitigation;Role;Rural;rural area;Rural Community;rural setting;Sampling;Selenium;Soil;soil sampling;Source;source localization;stressor;Structure of nail of toe;Superfund;superfund site;System;Technology;Toxic Environmental Substances;toxic metal;urban area;urban children;Urban Community;Urine;wasting;Water;water sampling;Water Supply;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Nutrition

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Nutrient handling is dependent on transport mechanisms across the intestine and the cellular plasma membrane. This process is carried out by membrane proteins that are constantly moving between the cell surface and other intracellular locations, such as the endosomal network. The studies proposed here seek to uncover the molecular mode of action of newly discovered cellular proteins that regulate the movement of nutrient transporters between the plasma membrane and the endosome, and assess their impact on nutrition in living animals

PI_NAMEs: BILLADEAU, DANIEL D;BURSTEIN, EZRA  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Actins;Affect;AGFG1 gene;Alleles;Animals;Attention;Back;Binding;Biochemical;Cardiac;Cell Line;Cell membrane;Cell Physiology;Cell surface;Complex;Copper;Data;Defect;Development;Elements;Endosomes;Excretory function;Family;Family member;Funding;Genes;Glucose;glucose tolerance;GLUT-2 protein;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Homeostasis;in vivo;Insulin;Intestines;Laboratories;LDL Cholesterol Lipoproteins;Lipids;Liver;Location;Mediating;member;Membrane Proteins;Molecular;mouse model;Movement;Mutation;myotubularin;notch protein;Nutrient;nutrition;Pathway interactions;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physiological;Plasma;Play;Process;Proteins;Proteomics;Publishing;receptor;recruit;Recycling;Regulation;Reporting;response;sorting nexins;System;Testing;trafficking;Wilson disease protein;Work

PROJECT_TITLE: Regulation of Nutrient Homeostasis by COMMD proteins

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative The cerebellum coordinates a number of processes including balance control, speech and spatial memory; abnormal development of the cerebellum is associated with a number of neurological diseases including medulloblastoma (MB), the most common malignant brain tumors in children. This proposal utilizes a number of state-of-the-art tools and techniques to investigate the role of YBX1 in regulating stem cell self- renewal and differentiation in the cerebellum and in MB using both mouse and human models. Results from these studies will lead to insights in epigenetic regulation of cerebellar development and the development of MB and further our understanding of the molecular mechanisms underlying YBX1 function which might lead to the design of novel therapeutic approaches for the treatment of MB.

PI_NAMEs: EVANS, MYRON K (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Affect;Age;antagonist;Award;Binding;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biology;Birth;Brain;Cancer Biology;career;Cells;Central Nervous System;Cerebellum;Child;Childhood Malignant Brain Tumor;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive function;Collaborations;Complex;Core Facility;CRISPR/Cas technology;design;Development;Disease;Disease Progression;DNA;DNA binding protein B;Embryo;Epigenetic Process;epigenetic regulation;Equilibrium;experimental study;extracellular;Fellowship;Functional disorder;Future;gain of function;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Generations;Genes;genome sequencing;genomic profiling;Goals;Growth;hindbrain;histone modification;human disease;human model;in vivo;inhibitor;innovation;insight;Institution;Knowledge;Language;loss of function;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Medulloblastoma;Mission;Modeling;Molecular;motor control;mouse model;Mus;Mutation;MYC gene;nerve stem cell;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear Translocation;overexpression;Patients;Pediatric Neoplasm;Persons;pharmacologic;Phase;Play;Polycomb;Positioning Attribute;Postdoctoral Fellow;postnatal;pre-doctoral;Process;progenitor;Prognosis;programs;Proliferating;Recurrence;Reporting;Research;research faculty;Research Proposals;RNA Interference;RNA-Binding Proteins;Role;Saint Jude Children's Research Hospital;Scientific Advances and Accomplishments;Scientist;self-renewal;SHH gene;Signal Pathway;Signal Transduction;spatial memory;Specific qualifier value;Speech;stem cell biology;stem cell self renewal;Structure;Subgroup;Technical Expertise;Techniques;therapeutic target;tool;Training;transcriptome sequencing;transcriptomics;Translating;tumor;Tumor Biology;tumor growth;tumorigenesis;whole genome;Work;Xenograft procedure

PROJECT_TITLE: Elucidating the role of Ybx1 in cerebellar development and medulloblastoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative  The Delaware Center for Musculoskeletal Research (DCMR) will support basic and pre-clinical research on the central theme of musculoskeletal health from the entire body to the molecule, with emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. Completion of this Phase I COBRE will build cross-cutting and synergistic research collaborations across multi-scales and multidisciplinary Projects and establish a state-of- the-art Research Core.

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Area;Basic Science;Biological;Biological Process;Biology;career development;Cell Communication;Cells;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Communities;Complement;Cues;Degenerative polyarthritis;Delaware;Equipment;Extramural Activities;Faculty;faculty mentor;Fostering;Functional disorder;functional restoration;Funding;Goals;Grant;Health;Homeostasis;improved;Inflammation;Injury;Interdisciplinary Study;Leadership;mechanical force;mechanical signal;Mechanics;Mentors;Metabolism;Molecular;multidisciplinary;Muscular Atrophy;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Organ;Osteoporosis;Phase;pre-clinical research;programs;recruit;repaired;Research;Research Personnel;Research Project Grants;Research Support;Role;Signal Transduction;Structure;success;synergism;Technical Expertise;Testing;Therapeutic Intervention;Tissues;Training;transmission process;Universities


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Of persons living with HIV, up to 90% have been infected with hepatitis B and up to 10% have chronic hepatitis B, but currently no cure is available. Using novel techniques and specimens, this proposal will provide data on the role of the humoral immune response including neutralizing antibodies in plasma, the B cell repertoire, and monoclonal antibodies in natural control of HBV and how these are affected by HIV. These data could lead to a functional cure for HBV in people with and without HIV.

PI_NAMEs: BAILEY, JUSTIN RICHARD (contact)

PROGRAM_OFFICER_NAME: PTAK, ROGER

PROJECT_TERMS: Acute;Acute Hepatitis;acute infection;Adult;Affect;Affinity;Aftercare;Antibodies;Antibody Response;Antibody Therapy;Antibody titer measurement;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Blood;Characteristics;Chronic;Chronic Hepatitis B;chronic infection;Cirrhosis;co-infection;cohort;Cohort Studies;Data;Development;Epitopes;follow-up;Hepatitis B;Hepatitis B Antibodies;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;HIV;HIV Antibodies;HIV Infections;HIV Seronegativity;HIV-1;Human;human subject;Immune response;Immunocompetent;Immunoglobulin Somatic Hypermutation;In Vitro;Individual;Infection Control;innovation;Knowledge;Measures;Molecular;Monoclonal Antibodies;neutralizing antibody;next generation sequencing;novel;novel strategies;Outcome;Participant;Persons;Plasma;Primary carcinoma of the liver cells;response;Risk;Role;Sampling;Sorting;Specimen;Surface Antigens;System;Techniques;Testing;Time;Translating;Viral;Virus Diseases;Visit

PROJECT_TITLE: The role of neutralizing antibodies in natural and treatment-induced control of hepatitis B with and without HIV-1 co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention;Telehealth

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: TATE, DEBORAH F. (contact)

PROJECT_TERMS: acceptability and feasibility;access restrictions;Administrator;Adult;Advocate;Awareness;behavior change;Behavior Therapy;Behavioral;Behavioral Sciences;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Caregivers;chemotherapy;Client;Clinical;Collaborations;Communication;community engagement;Community Outreach;Computer software;Computer Systems;cost effectiveness;Data Analyses;Data Collection;Data Sources;design;Development;Devices;Disadvantaged;Doctor of Philosophy;efficacy testing;eHealth;Emerging Technologies;Ensure;Evaluation;evidence base;Evidence based intervention;experience;Faculty;faculty research;Funding;General Population;Goals;handheld mobile device;Health;health application;health communication;Health Services;Healthcare;hormone therapy;Hour;ideation;Institution;Internet;Intervention;Intervention Studies;Interview;Malignant neoplasm of prostate;Maps;Measures;member;Methods;Mission;Mobile Health Application;Modernization;Monitor;new technology;Noninfiltrating Intraductal Carcinoma;Online Systems;Participant;Patient Outcomes Assessments;Patients;peer;Penetration;Perception;Persons;Phase;Population;Prevention;Process;programs;Provider;Psychosocial Factor;Qualitative Research;quality assurance;Quality of life;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;Risk;rural area;Services;Site;Software Design;software development;Source;Specialist;staff intervention;Surveys;symptom management;System;tailored messaging;Techniques;Technology;technology development;Testing;therapy development;Time;timeline;usability;web app;web site;Work

PROJECT_TITLE: CHAI


NIH_SPENDING_CATS: Aging

PI_NAMEs: KORRICK, SUSAN A (contact)

PROJECT_TERMS: Address;Arizona;beneficiary;career;career networking;Center for Translational Science Activities;citizen science;Cognitive aging;cohort;Collaborations;Communication;Communities;community engagement;community partners;community research;Complement;computational chemistry;Creativeness;Data;Data Analyses;data management;Data Science;design;Development;Discipline;Educational process of instructing;Educational workshop;Ensure;Environmental Engineering technology;Environmental Epidemiology;Environmental Science;experience;Experimental Models;externship;Fostering;Future;Goals;Government Agencies;Government regulations;Growth;Hazardous Waste;human model;Impaired cognition;Individual;Industrialization;innovative technologies;Institution;International;Laboratories;late life;Lead;Leadership;meetings;Mentors;Metals;Molecular Genetics;National Institute of Environmental Health Sciences;Neurosciences;New England;operation;Participant;peer;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health;Public Health Practice;Qualifying;Regulation;remediation;Reporting;Reproducibility;Research;Research Activity;Research Project Grants;Research Training;Resource Development;Resources;Risk Assessment;Role;Science;Scientific Inquiry;Scientist;Series;Signal Recognition Particle;skills;Source;statistics;Students;Superfund;Training;training opportunity;translational potential;Translational Research;Universities;webinar;Work

PROJECT_TITLE: Research Experience and Training Coordination Core (RETCC)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Heart valve disease affects up to 13% of the population in the US and there are limited effective treatment options available. Therefore, the proposed study is relevant to public health as it explores the potential of developing new therapeutic approaches in the treatment of heart valve disease based on promoting intrinsic mechanisms of self-repair. Successful completion will advance the field by improving clinical management and outcomes for affected patients.

PI_NAMEs: LINCOLN, JOY  (contact);LINDNER, VOLKHARD

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Aging;Aortic Injury;Aortic Rupture;aortic valve;Aortic Valve Stenosis;Cells;Childhood;Clinical;Clinical Management;Communication;Congenital Heart Defects;Congestive Heart Failure;design;Deterioration;Diagnosis;Disease;effective therapy;Endothelial Cells;endothelial dysfunction;endothelial repair;Endothelium;follow-up;Functional disorder;Functional impairment;Genetic Transcription;Heart Valve Diseases;Heart Valves;histological studies;Hour;Human;Impairment;improved;In Vitro;in vivo;Individual;Infant;Injury;innovation;interstitial;interstitial cell;Left;migration;Modeling;Molecular;mouse model;Mus;neonate;novel therapeutic intervention;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Paracrine Communication;Pathology;Patients;Pediatrics;Population;Predisposition;prevent;Process;Proliferating;Proteomics;Public Health;repaired;Reporting;response;response to injury;restoration;Signal Transduction;Site;Testing;Therapeutic;therapeutically effective;Tissues;transcriptomics;Treatment Step;Work

PROJECT_TITLE: Delineating the mechanisms underlying heart valve endothelial repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Project Narrative  Loss of inhibitory tone and aberrant hippocampal adult neurogenesis likely contribute to increased seizure susceptibility after traumatic brain injury, but a thorough understanding of the mechanisms causing post-traumatic epilepsy remain poorly understood. This project aims to study how potential dysfunction of the parvalbumin-positive basket cells, key mediators of early GABAergic signaling for immature neurons in the hippocampus, contributes to the pathogenesis of epilepsy, and if this process is linked to the role these interneurons play during hippocampal adult neurogenesis. Through these experiments, we will improve our understanding of aberrant neurogenesis after brain injury and how this affects the process of epileptogenesis. By directly testing translational approaches to prevent epilepsy, this work will aid in the development of new therapeutic approaches to mitigate seizure susceptibility in the Veteran patient population.

PI_NAMEs: BUTLER, CORWIN  (contact)

PROJECT_TERMS: Acute;Adult;adult neurogenesis;Affect;Anatomy;Animal Model;Animals;Area;Automobile Driving;Brain;Brain Injuries;Brain region;Calcium Channel;calcium indicator;Cell Maturation;Cell Physiology;Cells;Clinical Data;cohort;combat;Communities;controlled cortical impact;Data;dentate gyrus;Development;Disease;Electrophysiology (science);entorhinal cortex;Epilepsy;epileptiform;Epileptogenesis;experience;experimental study;Failure;Frequencies;Functional disorder;Funding;Future;gamma-Aminobutyric Acid;Genetic;Goals;granule cell;Hilar;Hippocampus;Histologic;Homeostasis;improved;improved outcome;in vivo;injured;Injury;Interneurons;Intervention;Knowledge;Label;Learning;Life;Link;Measures;Medial;medial temporal lobe;Mediating;Mediator;Medical;Membrane Potentials;Memory;Middle East;Military Personnel;Modeling;Monitor;mouse model;Mus;Myoepithelial cell;nerve supply;Nervous System Disorder;neuroblast;neurogenesis;neuronal circuitry;Neurons;Neurosciences;neurotransmitter release;novel therapeutic intervention;optogenetics;Output;Parvalbumins;Pathogenesis;Pathway interactions;patient population;Patients;Pharmacogenetics;pharmacologic;Phase;Play;Population;Post-Traumatic Epilepsy;Predisposition;preservation;presynaptic;prevent;Prevention strategy;Process;programs;Proliferating;receptor;recruit;Recurrence;Regulation;Research;Research Personnel;response;Rest;Retroviral Vector;Retroviridae;Role;Seizures;selective expression;sham surgery;Signal Transduction;Slice;Structure;Synapses;Techniques;Temporal Lobe Epilepsy;Testing;therapeutic development;Training;Transgenic Mice;translational approach;translational study;Trauma;Traumatic Brain Injury;treatment strategy;Veterans;Viral;Work

PROJECT_TITLE: Role of hippocampal interneurons in aberrant neurogenesis and epilepsy after traumatic brain injury


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Cachexia is a syndrome of cancer that promotes severe weight loss and is a major contributor to patient morbidity and mortality. This proposal explores the role of NF-kB in the muscle microenvironment that we believe will provide new insight to improve current therapeutic strategies for cachexia treatment and cancer care.

PI_NAMEs: GUTTRIDGE, DENIS C (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adipose tissue;Anabolism;Androgen Therapy;Anti-Inflammatory Agents;Appetite Stimulants;Area;Atrophic;Back;bench to bedside;Body Weight;Body Weight decreased;Cachexia;Cancer Cachexia;cancer care;Catabolism;Cells;Cessation of life;chemokine;chemotherapy;Chronic Disease;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Clinic;combat;cytokine;Data;Death Rate;Disease;effective therapy;Event;Fatigue;Fatty acid glycerol esters;frailty;GDF8 gene;Goals;Heart failure;Immune;improved;Inflammation;Inflammatory;inflammatory milieu;insight;Laboratories;Link;Macrophage;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Morbidity - disease rate;mortality;Mus;Muscle;muscle form;muscle progenitor cell;Muscle Proteins;Muscular Atrophy;Myoblasts;Natural regeneration;NF-kappa B;novel therapeutics;Operative Surgical Procedures;pancreatic cancer patients;Patients;phase II trial;Phase III Clinical Trials;Phenotype;Prevalence;prevent;primary endpoint;Process;Production;programs;Proteins;Radiation therapy;recruit;Regulation;repaired;Research;response;Rheumatoid Arthritis;Role;Sampling;Sarcolemma;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;stem cells;Syndrome;Testing;Therapeutic;therapeutic target;Translating;tumor;wasting;Weight

PROJECT_TITLE: NF-kB Regulation of the Muscle Microenvironment in Cancer Cachexia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE This study will examine the association between prenatal and early childhood metal exposures and late life cognitive function, as well as the role of adult metal exposures and whether early life metal exposures modify the effect of adult exposures. In a subset of a population that donated their baby teeth as children and is now in their 60’s and 70’s, we will analyze metals in those previously collected baby teeth to assess early life exposures, and collect toenail clippings to assess adult metal exposure, and relate those to performance on cognitive tests. We will also assess micro RNA (miRNA) profiles from extracellular vesicles in blood of the adults to examine possible epigenetic mechanisms underlying the investigated associations.

PI_NAMEs: WEISSKOPF, MARC G (contact)

PROJECT_TERMS: Ablation;Address;Adult;age related;aging brain;aging population;Alzheimer's Disease;American;Animal Experimentation;Animals;Biological;Biological Markers;Blood;Blood specimen;Cells;Child;Clip;Cognitive;Cognitive aging;cognitive development;cognitive function;cognitive testing;Cohort Studies;cost estimate;Data;Dementia;Dental Enamel;Deposition;Disease;early childhood;early detection biomarkers;early life exposure;Economic Burden;economic cost;Elderly;Encapsulated;Enrollment;Environmental Exposure;Epigenetic Process;Exposure to;extracellular vesicles;Gene Expression;Health;Home;Human;human old age (65+);human study;Impaired cognition;in utero;Individual;Inductively Coupled Plasma Mass Spectrometry;Industrialization;Intervention;Lasers;Late Effects;late life;lead exposure;Life;Link;Lipid Bilayers;Measures;men;Metal exposure;Metals;MicroRNAs;Modification;nanoscale;Neurons;novel marker;older adult;Older Population;Outcome;Participant;particle;Pathology;Patients;Performance;Population;postnatal;prenatal;Public Health;Questionnaires;recruit;remediation;Research;Risk;Risk Factors;Role;Sampling;Series;Serum;Signal Transduction;Site;Source;Structure of nail of toe;Superfund;superfund site;Testing;Therapeutic;Time;Tooth structure;United States;water sampling;Woman;Work

PROJECT_TITLE: Metals, critical windows of exposures, epigenetics, and late life cognitive function


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services

ORG_CITY: CHAPEL HILL

PI_NAMEs: OLSHAN, ANDREW  (contact)

PROJECT_TERMS: analytical method;anti-cancer research;Applications Grants;Awareness;beneficiary;Big Data;Biological;Breast;Budgets;Cancer Center;Cancer Center Support Grant;Catchment Area;Cessation of life;cohort;Collection;Colon;Communication;comparative effectiveness;Comprehensive Cancer Center;Computer software;cost effective;cost effectiveness;Data;Data Analyses;Data Analytics;data management;Data Protection;data registry;data repository;data resource;Data Set;data sharing networks;Databases;Development;Diagnosis;Diagnostic;Diffusion of Innovation;Disparity;Elements;Endometrial;Ensure;Epidemiology;epidemiology study;Etiology;Faculty;Funding;Genetic;Goals;Head and Neck Cancer;Health;Health Resources;Health Services Accessibility;Health Services Research;Healthcare;Hospital Registrar;Hospitals;Human Resources;Individual;Industry;Infrastructure;innovation;Institution;Institutional Review Boards;Insurance;Insurance Carriers;Interdisciplinary Study;Interview;Link;Malignant Neoplasms;Manuscripts;Medicaid;Medicare;Melanoma;member;Methodology;Methods;Morbidity - disease rate;neoplasm registry;North Carolina;operation;Outcome;Outcome Study;Outcomes Research;Patient-Focused Outcomes;Patients;Patterns of Care;peer;Performance;Population;population based;population health;Population Sciences;Population Study;Positioning Attribute;Prevention;Privatization;Process;programs;Prostate;Research;Research Methodology;Research Personnel;research study;Research Support;Resource Sharing;Resources;Secure;Services;Source;Specimen;Statistical Data Interpretation;survivorship;tool;tumor;Universities;Writing

PROJECT_TITLE: Statewide Cancer Data


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: PROJECT NARRATIVE Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully extracting return on investment from neurophysiology experiments. The goal of this proposal is to disseminate the award-winning, community-driven Neurodata Without Borders (NWB) neurophysiology data standard and software technologies developed as part of the NIH BRAIN Initiative broadly to the neuroscience research community. To lower the barrier of adopting NWB, we propose a multifaceted plan to make NWB easier to use by focusing on the needs of 1) neuroscience researchers and laboratories by enhancing user training, support, and coverage of new technologies and 2) neuroscience tools and technologies by maintaining core NWB technologies and integrating with a wide array of powerful data tools and technologies.

PI_NAMEs: DICHTER, BENJAMIN K;RUEBEL, OLIVER  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Adopted;Area;Award;Behavior;Brain;BRAIN initiative;Catalogs;Communities;Computer software;Conscious;cost;Data;data acquisition;Data Analyses;data integration;data management;data pipeline;data reuse;Data Set;data sharing;data standards;data tools;design;Documentation;Ecosystem;Emerging Technologies;Esthesia;Event;experimental study;Goals;Imaging technology;improved;Incentives;Institution;Investments;Laboratories;Learning;Measures;Memory;Metadata;Methods;Neurons;neurophysiology;Neurosciences;Neurosciences Research;new technology;Perception;Persons;Process;Protocols documentation;Publications;Reproduction;Research;Research Personnel;Resources;Science;Scientist;Services;Standardization;Structure;support tools;Technology;Testing;Thinking;Time;tool;Training;training opportunity;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Advancing Standardization of Neurophysiology Data Through Dissemination of NWB


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This proposal seeks to elucidate the cellular and molecular mechanisms that control the balance between self-renewal of blood progenitors and differentiation of mature blood cell types. Understanding how this balance is established during normal development and maintained during stress is relevant to blood disorders characterized by the production of disproportionate blood cell types such as fatal myeloproliferative disorder, anemia, and immune dysfunction upon aging. This work will help establish a model system that will allow for real-time monitoring of the blood system and ultimately the identification of key factors that regulate cell division and cell fate during hematopoiesis.

PI_NAMEs: GOINS, LAUREN MONICA (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;Aging;Anemia;Biological Models;Blood;Blood Cells;Bone Marrow;career;career development;Cell Count;Cell Cycle;Cell division;Cell Lineage;Cell Polarity;cell type;Cells;Cellular biology;Characteristics;Collaborations;Committee Members;Complex;Cues;Cytoskeleton;deprivation;Development;Disease;Dissection;Drosophila genus;Equilibrium;experience;experimental study;Faculty;Fluorescent Antibody Technique;Foundations;Genetic;genetic regulatory protein;Genetic Techniques;Goals;Grant;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Homeostasis;Human;Hypoxia;Image;Imaging Techniques;Imaging technology;Immune System Diseases;In Vitro;in vivo;Injury;Institution;International;Journals;Knowledge;Laboratories;Leadership;Link;Maintenance;Mammals;member;Mentors;Mentorship;Modeling;Molecular;Monitor;mutant;Myeloproliferative disease;nutrient deprivation;Oxygen;Pathway interactions;Positioning Attribute;Production;programs;Proteins;Publishing;real time monitoring;Regulation;Research;Research Design;Research Personnel;Resolution;Resources;response;rho GTP-Binding Proteins;RNA Interference;Role;Running;Scientist;self-renewal;Signal Transduction;skills;stem cell population;Stress;stressor;symposium;System;Techniques;Time;tool;Training;Training Activity;transcriptomics;Translating;Work;Writing

PROJECT_TITLE: Mechanisms of Asymmetric Cell Division in Developmental Hematopoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Early-life exposure to environmental metal toxicants is associated with worse cognitive function in aging and may contribute to the development of neurodegenerative diseases, such as Alzheimer’s disease; however, the underlying molecular mechanisms remain poorly understood. This project conducts laboratory-based mechanistic studies to unravel critical biological pathways that contribute to cognitive aging associated with exposures to environmental metal contaminants. This study could lead to novel strategies that slow down cognitive aging and dysfunction caused by metal exposures.

PI_NAMEs: LU, QUAN  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Age Months;Aging;aging related;Alzheimer's Disease;Anatomy;Arsenic;Biological;Biological Assay;Biological Markers;Blood;Brain;brain cell;Cadmium;Cell Physiology;Cells;Cognitive;Cognitive aging;cognitive function;cohort;Communities;community engagement;Complement;contaminated water;Data;Data Analyses;data management;Development;Disease;drinking water;early life exposure;education research;Encapsulated;Environmental Exposure;Epidemiology;Exposure to;extracellular;extracellular vesicles;Fetal Tissues;Gene Expression;Goals;Health;Human;human disease;human fetal brain;Impaired cognition;in vivo;Individual;intercellular communication;Laboratories;late life;Lead;Life;Link;Lipid Bilayers;Liquid substance;Mammalian Cell;Manganese;Mediating;Mediator;Membrane;Messenger RNA;Metal exposure;Metals;Methodology;Methods;MicroRNAs;Molecular;molecular marker;mouse model;multidisciplinary;Mus;nerve stem cell;neurobehavioral;Neurodegenerative Disorders;neuroimaging;Neurons;neurotoxicity;novel marker;novel strategies;nuclease;Organoids;Outcome;Pathway interactions;Plasma;postnatal period;prenatal;Proliferating;remediation;Research;response;Role;self-renewal;Serum;Signaling Molecule;social;Source;stem cell function;Superfund;superfund site;Testing;three dimensional cell culture;toxicant;Training and Education;training opportunity;transcriptome sequencing;Transfection;Translational Repression;Translational Research;Vesicle;Water;water sampling;Work

PROJECT_TITLE: EV miRs in cognitive function decline associated with early life metal exposure


ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Obtained from the diet, the metal manganese is essential for health yet can be toxic in excess. Our research investigates the mechanisms by which manganese levels are regulated in the body. Our studies will enable us to better identify those at risk of manganese-related disease and treat those affected by such diseases.

PI_NAMEs: BARTNIKAS, THOMAS BENEDICT (contact)

PROJECT_TERMS: absorption;Affect;Anemia;Antisense Oligonucleotides;Apical;Attenuated;Bile fluid;Biliary;Biology;Blood;Copper;Data;Defect;design;Development;Diet;dietary;Dietary Iron;Disclosure;Disease;Enterocytes;Erythropoiesis;Erythropoietin;Excretory function;Extrahepatic;Functional disorder;Funding;Gastrointestinal tract structure;Genes;Genetic;Goals;Health;Hematology;Hepatobiliary;Hepatocyte;hepcidin;Hereditary Disease;Homeostasis;Hormones;Human;Hypoxia;Impairment;in vivo;Inherited;inhibitor;Intestines;Investments;Iron;iron absorption;iron deficiency;Knockout Mice;Link;Liver;Liver diseases;Maintenance;Manganese;Metabolic;metal transporting protein 1;Metals;Microscopic;Modeling;Molecular;Mus;Mutant Strains Mice;Mutation;Nervous System Disorder;Neurologic;novel;Nutrient;Organ;Pathology;Pathway interactions;Patients;pharmacologic;Physiological;Play;Polycythemia;Protein Export Pathway;Radioisotopes;Red Blood Cell Count;Reporting;Research;Risk;Role;Small Intestines;stem;Techniques;Testing;Therapeutic;Toxic effect

PROJECT_TITLE: Molecular Basis of Mammalian Manganese Homeostasis