ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 13-26 who are at Clinical High-Risk (CHR) for developing psychosis. Leveraging the Health Action Process Approach (HAPA) model, we will identify help-seeking subtypes in 25,000 youth who screen positive for psychosis-risk on Mental Health America’s national online screening platform, iteratively develop and test theory and data-driven, personalized strategies to advance help-seeking using Micro- Randomized Trials and a Sequential Multiple Assignment Randomized Trial, identify the most accurate CHR screening threshold in an online environment, and link youth, when indicated, to local clinical care via AMP-SCZ, a NIH funded national network of CHR programs throughout the US. Our academic-industry partnership aims to curate one of the largest datasets of youth with CHR, and to develop effective strategies to enhance early help- seeking, in a population where help-seeking is critical and a significant barrier to care.

PI_NAMEs: BIRNBAUM, MICHAEL LEO (contact);LOEWY, RACHEL L.

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Address;advocacy organizations;Age;Awareness;barrier to care;Behavioral;care seeking;Caring;Case Mixes;Clinical;Clinical assessments;clinical care;Clinical Management;Collaborations;computerized data processing;cost;Data;Data Set;Dedications;demographics;design;Development;Diagnostic;digital;digital delivery;digital healthcare;digital mental health;Distress;Early identification;Early Intervention;early psychosis;Education;effective therapy;effectiveness testing;Environment;evidence base;Expectancy;Frequencies;functional outcomes;Funding;Goals;Health;help-seeking behavior;high risk;Impairment;improved;Individual;industry partner;innovation;Intake;Intention;Intervention;Knowledge;Laboratories;large datasets;Linguistics;Link;Maintenance;Mental Health;Metadata;Modeling;natural language;Natural Language Processing;Odds Ratio;online resource;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;peer;personalized strategies;Population;population based;Prevalence;Process;programs;Provider;Psychoses;psychosis risk;Public Health;Qualifying;Questionnaires;randomized trial;Recommendation;Recovery;Research;research clinical testing;Resources;response;Risk;Risk Reduction;Sampling;screening;Self Direction;Self Efficacy;Sensitivity and Specificity;Sequential Multiple Assignment Randomized Trial;Series;service intervention;severe mental illness;Severities;Symptoms;Telephone;Testing;Text;Text Messaging;theories;Time;tool;trial design;United States National Institutes of Health;video chat;web site;Youth

PROJECT_TITLE: Digital Strategies to Advance Help-Seeking in Youth at Clinical High Risk for Developing Psychosis

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE: Cardiac myosin binding protein-C (cMyBP-C) is an essential muscle protein that is necessary for normal cardiac contraction and is required for increased contractility in response to fight-or-flight stimuli. The importance of cMyBP-C to cardiac function is further highlighted because cMyBP-C dysregulation occurs during heart failure and mutations in the gene encoding cMyBP-C are the most common cause of hypertrophic cardiomyopathy (HCM). The proposed experiments will use a novel method developed in the PI’s lab to investigate how cMyBP- C interacts with actin and myosin, the two main proteins responsible for generating force in the heart, using functional force assays and X-ray diffraction to determine muscle structure.

PI_NAMEs: HARRIS, SAMANTHA P (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Actins;Affinity;Binding;Biochemical;Biological Assay;C10;Calcium;Calmodulin;Cardiac;Cardiac Myocytes;Cardiac Myosins;Complex;Data;Diastole;Disease;experimental study;fighting;Filament;Functional disorder;Genes;Genetic;Goals;Health;Heart;Heart failure;heart function;Hypertrophic Cardiomyopathy;In Vitro;insight;Kinetics;Length;Link;Measurement;mechanotransduction;Methods;Modification;Molecular;Molecular Conformation;Muscle Contraction;Muscle Proteins;Muscle relaxation phase;muscular structure;Mutation;Myocardial Contraction;Myocardial dysfunction;Myocardium;Myofibrils;Myosin ATPase;myosin-binding protein C;N-terminal;novel;Paste substance;Permeability;Phosphorylation;Play;Point Mutation;Positioning Attribute;Post-Translational Protein Processing;Proteins;Recombinant Proteins;Regulation;Relaxation;Research;response;Role;Sarcomeres;Serine;Sorting;Starling (law);Stimulus;Stretching;Structure;System;Systole;Testing;Thick;Thick Filament;Thin Filament;Thinness;Time;X ray diffraction analysis

PROJECT_TITLE: Role of Cardiac Myosin Binding Protein-C in the Regulation of Myocardial Contraction

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Food Allergies;Infectious Diseases;Nutrition;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  We have identified a group of patients who develop delayed anaphylaxis 3-6 hours after eating beef, pork or lamb and the allergy appears to begin after tick bites, even in people who have tolerated these meats their entire lives. We now have a unique molecular approach that will help us learn why the allergic response to tick bites occurs and why patients are suddenly becoming allergic to red meat. Answers to these questions will provide real insight for patients suffering from either tick-borne illness or food allergy as we begin to unravel the factors that control immune responses to tick bites and allergic responses overall.

PI_NAMEs: COMMINS, SCOTT PALMER (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adult;Affect;Allergens;Allergic;Allergic Reaction;allergic response;alpha-gal syndrome;Amblyomma;Ambylomma americanum;Anaphylaxis;Antibodies;Antibody Response;Awareness;beef;Bite;Blood specimen;Case Study;Cells;Cessation of life;Cetuximab;cohort;County;Data;Development;Disease Vectors;Eating;Ehrlichiosis;Enrollment;Environment;Enzymes;epidemiologic data;Epidemiology;Epitopes;Etiology;Exposure to;Food;Food Hypersensitivity;Funding;Galactosidase;galactosyl-(1-3)galactose;Genetic;Geography;Goals;Health;Hour;Human;Human Bites;human old age (65+);human subject;Hypersensitivity;IgE;Immune response;Immunophenotyping;Incidence;indexing;Individual;Ingestion;Insecta;insight;intradermal injection;Intravenous;Investigation;Learning;Life;Link;Longitudinal cohort;Measures;Meat;Medical;Medicare/Medicaid;Messenger RNA;microbiome;Midgut;Molecular;mortality;mouse model;Mus;Natural History;North Carolina;novel;Oligosaccharides;Oral;Outcome;Participant;pathogen;Patients;Persons;Population Study;Positioning Attribute;Prevalence;Prevention;Production;Prospective Studies;Questionnaires;radiological imaging;Reaction;Reporting;Research;residence;response;Rickettsia Infections;Risk;Risk Factors;Risk Management;Role;rural counties;Salivary;Salivary Glands;Sampling;serological marker;single-cell RNA sequencing;Skin;Specimen;spotted fever;Surface;Surveys;Testing;tick bite;tick saliva;Tick-Borne Diseases;Tick-Borne Infections;Ticks;Transcription Initiation;transcriptomics;Work

PROJECT_TITLE: Understanding alpha-gal red meat allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The Chr10q26 locus, containing ARMS2/HTRA1, has been found in large scale human population studies to contribute to a significant proportion of the risk for developing age-related macular degeneration (AMD), one of the leading causes of vision impairment and loss in the aging population. Due to strong linkage disequilbrium between the two genes, it is still unclear which gene (or both) contribute to the increased risk. In this application, we plan to further determine if the disease phenotypes observed in mice bearing an ARMS2A69S allele might be due to reduction in the integrity of the outer blood retinal barrier or to mitochondrial dysfunction and determine whether environmental factors such as consumption of a high fat diet, or genetic factors such as rare human complement factor H disease alleles exacerbate the disease in ARMS2A69S mice.

PI_NAMEs: NISHINA, PATSY M (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 10q26;3' Untranslated Regions;Address;Adhesions;Affect;Age related macular degeneration;aging population;Alleles;Animal Model;Biochemical;Blindness;Blood-Retinal Barrier;Candidate Disease Gene;Cell Adhesion;Cell Proliferation;cell type;Cells;Cellular Morphology;Clinical;comparison control;Complement Factor H;complement pathway;Consumption;cost;CRISPR/Cas technology;Deposition;Development;Diet;Disease;disease phenotype;disease-causing mutation;disorder risk;effective therapy;Elements;Environmental Risk Factor;Epithelium;Evaluation;Extracellular Matrix;Eye;Frequencies;Gene Expression;Genes;Genetic;Genetic Crosses;genetic variant;genome editing;genome wide association study;genome-wide;genome-wide analysis;Goals;High Fat Diet;Histologic;Homeostasis;Human;human population study;in vivo;Individual;Inflammatory;insertion/deletion mutation;Intermediate Filaments;Lead;Learning;Link;Linkage Disequilibrium;Lipids;macula;macular dystrophy;Mediating;Mesenchymal;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;mouse model;Mus;Mutation;Nonexudative age-related macular degeneration;Oxidative Stress Induction;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phenotype;Pigmentation physiologic function;Precipitating Factors;prevent;Primates;Proteomics;Research Personnel;Resources;Retinal Degeneration;Risk;Risk Factors;risk variant;Role;Severity of illness;Structure;Structure of retinal pigment epithelium;Susceptibility Gene;Testing;therapeutic evaluation;Tissues;transcriptomics;trend;Twin Studies;Uncertainty;Variant;Visual impairment;western diet

PROJECT_TITLE: Role of ARMS2 mutations in age-related macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative_________________________________________________________________________ Insufficient sleep predicts drug-related problems and drug use, and may predispose relapse to drug taking. This research project will investigate if a history of insufficient sleep increases methamphetamine intake, and whether a specific brain system – the orexin/hypocretin system – is involved in this phenomenon. The results of these studies may lead to new and more broadly effective medications that will target both methamphetamine abuse and related insomnia.

PI_NAMEs: BERRO, LAIS F (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: actigraphy;addiction;Address;Adult women;Agonist;antagonist;behavior observation;behavioral economics;Biological Factors;Blood;Brain;Circadian desynchrony;Circadian Rhythms;Clinical;Consumption;Coupled;Data;Development;Dimensions;Disease;Diurnal Rhythm;Dose;Drug usage;Effectiveness;Electroencephalography;Epidemic;experimental study;Female;Health;High Prevalence;high risk;Human;hypocretin;Individual;Intake;Ligands;Link;Macaca mulatta;male;Measures;Mediator;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;methamphetamine effect;Methamphetamine misuse;methamphetamine use;Methamphetamine use disorder;Monkeys;novel;orexin 1 receptor;orexin A;orexin B receptor;overdose death;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Play;poor sleep;Prevalence;Probability;Process;Property;psychosocial;Public Health;receptor;Recording of previous events;Regulation;Relapse;Research;Research Project Grants;Role;Self Administration;Serum;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Sleeplessness;Study models;substance use;Substance Use Disorder;System;Telemetry;virtual;Wakefulness

PROJECT_TITLE: Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin Mechanisms

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: HUNTSVILLE

ORG_NAME: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY

ORG_STATE: AL

PHR: Project Narrative Genome sequencing technologies have greatly improved our ability to detect the genetic causes of rare diseases, such as neurodevelopmental disorders (NDDs), but disease-relevant genetic variants still cannot be found in most individuals with a rare disease. New sequencing technologies hold great potential to uncover genetic variation missed by current approaches, and this proposal tests one such approach, called “HiFi”, from Pacific Biosciences. 500 probands, and 400 of their parents, with an unexplained rare disease will be sequenced using HiFi to identify disease-associated, clinically relevant variants and to substantially improve upon sequencing technologies in research and clinical settings.

PI_NAMEs: COOPER, GREGORY MICHAEL (contact);GRIMWOOD, JANE ;SCHMUTZ, JEREMY

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Affect;African American population;Alleles;analytical method;Area;Basic Science;Benchmarking;Biological;Biological Sciences;Child;Chromosomal translocation;Chromosome 6;Chromosome Mapping;Chromosomes;Clinical;clinical application;clinically relevant;cohort;Collaborations;Communities;Complex;Consent;cost;Data;data quality;Data Set;Detection;Diagnosis;Diagnostics Research;Disease;disease diagnosis;DNA;DNA Insertion Elements;DNA sequencing;Equilibrium;Equity;Family;Frequencies;gene discovery;Gene Frequency;Genes;Genetic;genetic counselor;Genetic Diseases;genetic variant;Genetic Variation;Genome;genome sequencing;genomic data;Genotype;Goals;Hand;Human Genetics;human genome sequencing;improved;Individual;LGR5 gene;Maps;Measures;Mediating;Mendelian disorder;Methods;Neurodevelopmental Disorder;Neurology;novel sequencing technology;pan-genome;Parents;Pathogenicity;Phase;Phenotype;phenotypic data;Population;proband;Process;Production;Publications;Qualifying;racial diversity;Rare Diseases;Research;Sampling;Schedule;sequencing platform;success;Symptoms;Technology;telomere;Testing;tool;Variant;variant of unknown significance;Work

PROJECT_TITLE: Long-read genome sequencing for the discovery of highly penetrant variation in rare diseases

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pregnant women with intellectual and developmental disabilities (IDD) are more likely to have adverse pregnancy and offspring outcomes, but it is unclear what factors are responsible for the increased risk. In this study, we will quantify the drivers of the excess risk of adverse reproductive outcomes in order to establish intervention targets for future study. This study will help to optimize reproductive outcomes in this highly vulnerable population.

PI_NAMEs: BANDOLI, GRETCHEN E. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accounting;Address;Adult;adverse birth outcomes;adverse maternal outcomes;Age Years;autism spectrum disorder;Awareness;Birth;Birth Records;California;Caring;Cerebral Palsy;Characteristics;Chronic;Chronic Disease;Clinical;Cognitive;cohort;comorbidity;Complex;Data;Data Set;Data Sources;Death Records;Diagnosis;Disability outcome;Disease;Disparity;disparity reduction;Drug Prescriptions;Epidemiologist;Etiology;Face;Fertility Rates;Fetal Alcohol Spectrum Disorder;Fetal Death;Future;Genetic Diseases;Grant;health disparity;Healthcare;hospital readmission;Hospitals;Individual;Infant;Infant Mortality;infant outcome;Intellectual functioning disability;interest;Intervention;Link;Low Prevalence;Maternal Health;maternal outcome;Maternal-fetal medicine;Measures;Mediating;Mediation;Mediator;Medicaid;Medical;Mothers;offspring;Outcome;Pathway interactions;Perinatal;Persons;Pharmaceutical Preparations;postnatal;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;prenatal;Prenatal care;Psychologist;Records;Reporting;reproductive;Reproductive Health;Reproductive History;reproductive outcome;Reproductive Rights;Research;Research Personnel;Risk;Smoking;social;Specialist;stillbirth;substance use;Time;United States National Institutes of Health;Vulnerable Populations;Woman;women with disabilities;women's outcomes;women's reproductive health;Work

PROJECT_TITLE: Maternal and Infant Outcomes among Pregnant Women with Intellectual and Developmental Disability

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Cerebral hyperthermia following brain injury occurs commonly, and often precedes significant changes in systemic temperatures. Minimal changes in brain temperature promote rapid deterioration in ischemic brain and produce severely worsened outcomes. Non-invasive means to measure pathologic brain temperature gradients are lacking and hence the need for prognostic biomarkers and treatment targets for dangerous cerebral hyperthermia remains unmet. Magnetic Resonance (MR) thermometry is a promising technique for non-invasive thermometry; this application introduces novel multinuclear thermometry approaches developed by the investigators, exhibiting unprecedented accuracy and performance for direct cerebral thermometry.

PI_NAMEs: ALON, LEEOR  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Animals;Binding;Body Temperature;Body Weight;Brain;Brain Injuries;Brain Ischemia;brain tissue;Cardiopulmonary;Cations;Cause of Death;Cerebral Ischemia;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chemicals;Clinical;clinical practice;cold temperature;Consumption;cost;Custom;Dangerousness;Dementia;Dependence;Detection;Deterioration;Development;diagnostic development;diagnostic tool;disability;Disease;Disease Outcome;Environment;Exhibits;Fever;Frequencies;Glucose;Goals;Heating;Human;human subject;Hyperthermia;hypoperfusion;Image;imaging approach;Immunity;Impairment;implantation;improved;in vivo;Interruption;Ischemia;ischemic injury;Local Hyperthermia;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Mediating;Metabolic;Metabolism;Modeling;Monitor;Morphologic artifacts;Motion;neuroimaging marker;Neurologic;Noise;nonhuman primate;novel;Nuclear;Outcome;Oxygen;Pathologic;Patients;Performance;Perfusion;Peripheral;Phase;Physiologic Thermoregulation;Physiological;Predisposition;preservation;prevent;Process;Prognostic Marker;prognostic tool;Protons;reconstruction;Rectum;Research Personnel;Risk;Rodent;Series;Signal Transduction;Sodium;Source;spatiotemporal;spectroscopic imaging;Speed;standard care;Stroke;stroke model;stroke patient;Techniques;Temperature;Testing;therapeutic target;Thermography;Thermometry;Thrombotic Stroke;Time;Tissues;Validation;Variant;wasting

PROJECT_TITLE: Absolute Brain Thermography using Multinuclear MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Chronic Pain;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: NARRATIVE This proposal focuses on the impact that glycosylation might have on corneal nerve regeneration and sensation. Towards this purpose, we propose to examine the composition of protein glycans in the mouse trigeminal ganglion and investigate the impact of altered glycosylation on corneal nerve repair, at the anatomical and functional levels. In doing so, we anticipate developing new strategies to promote functional reinnervation by targeting specific glycan metabolic pathways.

PI_NAMEs: ARGUESO, PABLO  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Anatomy;Animal Model;Blindness;Brain;Carbohydrates;cell type;Central Nervous System;Clinical;Cornea;Corneal Diseases;Corneal Injury;Corneal pain;Data;Development;Disease;Dryness;effective therapy;Enzymes;Esthesia;Feedback;Female;Fucose;Functional disorder;ganglion cell;Glycocalyx;glycosylation;Health;Image;Impairment;improved;In Situ Hybridization;in vivo;Individual;Infection;Inflammatory;injured;Injury;Ion Channel;Label;Lectin;macromolecule;Maintenance;male;Mass Spectrum Analysis;Metabolic Pathway;Mus;Natural regeneration;Nerve;Nerve Regeneration;nerve repair;nerve supply;Nerve Tissue Proteins;Nervous System;Neuroglia;Neurons;Neuropathy;neurotransmission;novel therapeutic intervention;ocular surface;Pain;pain signal;painful neuropathy;Pathogenesis;peripheral nerve damage;Peripheral Nervous System;Polysaccharides;Process;Production;Proteins;Proteomics;reinnervation;Research;Scaffolding Protein;Sensory;Sialic Acids;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Structure;Structure of trigeminal ganglion;Symptoms;Temperature;Testing;Therapeutic;Touch sensation;transmission process;Trauma;Trigeminal nerve structure;Trigeminal System

PROJECT_TITLE: Glycosylation in ocular surface health and disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: The overall objective of this project will be to utilize a novel human intestinal organoid (HIO) model system to test genetic mechanisms regulating tissue inflammatory responses and collagen production in patients with Crohn's Disease. These studies will advance precision medicine, by developing a platform to screen small molecules in patient-derived organoids stratified by clinically important genotypes, and ultimately prevent fibrotic end-organ injury.

PI_NAMEs: DENSON, LEE ARMISTEAD (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acids;Anti-Tumor Necrosis Factor Therapy;Bioinformatics;Biological Models;capsule;cell growth regulation;Cell Line;Cellular Metabolic Process;Clinical;Clinical stratification;Coculture Techniques;Collagen;Complex;CRISPR/Cas technology;Crohn's disease;CYBA gene;Cyclic AMP-Dependent Protein Kinases;cytokine;Disease;Epithelial Cells;Epithelium;Excision;Exhibits;Extracellular Matrix;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;genetic testing;genetic variant;Genotype;Goals;Human;Hydrogen Peroxide;Hyperplasia;Ileal Diseases;induced pluripotent stem cell;Inflammasome;Inflammatory;Inflammatory Response;intestinal epithelium;Intestines;Kidney;long chain fatty acid;loss of function;Macrophage;Mediating;Metabolism;Microbe;Mitochondria;Modeling;Monoclonal Antibodies;mucosal microbiota;Mucous Membrane;Mus;Myofibroblast;NADPH Oxidase;novel;Operative Surgical Procedures;organ injury;organoid transplantation;Organoids;Oxidation-Reduction;pathogen;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;Phagocytes;precision medicine;prevent;Production;profibrotic cytokine;programs;Protein Inhibition;Protein Kinase;Protein phosphatase;Proteins;Reactive Oxygen Species;Regulation;repaired;Research;Respiration;response;Signal Transduction;small molecule;Smooth Muscle;Specimen;Submucosa;Superoxides;System;Testing;TGFB1 gene;tissue culture;Tissues;TNF gene;Transcript;transcriptome;treatment response;Variant;Work

PROJECT_TITLE: Genetic and Small Molecule Regulation of Mechanisms of Crohn’s Disease Stricture Formation

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE The overall theme of this proposal is to develop a precision medicine approach to red blood cell matching for patients with sickle cell disease (SCD). We present innovative solutions to major clinical challenges of Rh alloimmunization in SCD. We aim to determine the effectiveness of RH genotype matched donor units on Rh alloimmunization, develop a low-cost RH sequencing assay with integrated interpretation to facilitate widespread implementation of RH genotype matching, and generate customized pluripotent stem cell-derived red blood cells with variant Rh for precise antibody identification, with the ultimate goal of improving transfusion outcomes.

PI_NAMEs: CHOU, STELLA T (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Address;African;Alleles;Alloimmunization;analysis pipeline;Antibodies;Antibody Formation;Antigenic Variation;Antigens;bench to bedside;Biological Assay;Biology;Black Populations;Black race;Blood;Blood donor;blood group;Blood typing procedure;care costs;Caring;Chronic;Clinical;clinical care;Complex;Complication;cost;Critical Illness;Custom;Data;Data Analyses;data analysis pipeline;design;Detection;Development;DNA;Donor Selection;effectiveness evaluation;Epitopes;Equipment and supply inventories;Erythrocyte Transfusion;Erythrocytes;Exhibits;exome sequencing;Feasibility Studies;Future;Genes;Genetic;Genetic Engineering;Genetic Heterogeneity;Genetic Recombination;genetic testing;genetic variant;genome editing;genome sequencing;Genotype;Goals;Hematology;Immune response;immunogenic;improved;Incidence;induced pluripotent stem cell;Informatics;innovation;Institution;Life;medical complication;Methods;Minority;Morbidity - disease rate;next generation sequencing;novel;Outcome;Patients;Pilot Projects;Pluripotent Stem Cells;Population Heterogeneity;precision medicine;Precision therapeutics;prevent;Prospective Studies;Proteins;Reagent;recruit;Rh-Hr Blood-Group System;Risk Factors;Sampling;Serology;Serology test;Sickle Cell Anemia;Source;Specificity;Structure;System;Technology;Testing;Time;Transfusion;transfusion medicine;user-friendly;Variant

PROJECT_TITLE: A precision therapy approach to red cell transfusion for sickle cell disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Hydrocephalus;Neurodegenerative;Neurosciences;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE While most cases of dementia are due to irreversible degenerative processes, normal pressure hydrocephalus can often be treated by cerebrospinal fluid diversion. However, accurate prediction of surgical outcome is difficult, particularly with noninvasive methods. Therefore, the overall goals of this work are to advance MR elastography technology to account for extracellular fluid effects, and to assess the value of these mechanical biomarkers to predict treatment outcomes.

PI_NAMEs: MURPHY, MATTHEW CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Accounting;accurate diagnosis;accurate diagnostics;Aftercare;Age;age-related disease;Algorithms;Alzheimer's Disease;Amyloid;Anatomy;Behavior;Biological Markers;Biomechanics;Biophysics;Brain;brain health;brain tissue;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;Cognitive;Control Groups;Creation of ventriculo-peritoneal shunt;Data;Dementia;Development;Diagnosis;diagnostic accuracy;diagnostic biomarker;diagnostic value;Diffusion;Discrimination;Disease;Elasticity;elastography;Elements;Environment;Equation;Etiology;experimental study;Extracellular Fluid;Extracellular Space;Frequencies;Gait;Goals;healthy volunteer;Image;improved;in vivo;Individual;insight;Joints;Knowledge;Learning;Liquid substance;Machine Learning;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Maps;Measurement;Measures;mechanical properties;Mechanics;Methodology;Methods;Modeling;Motion;Normal Pressure Hydrocephalus;Operative Surgical Procedures;Outcome;outcome prediction;Participant;Pathogenesis;Patient Care;Patients;Pattern;Persons;phenotypic biomarker;Porosity;Positioning Attribute;Prediction of Response to Therapy;preservation;Prevalence;Probability;Process;Prognosis;prognostic value;Property;Reporting;Research;Role;Shunt Device;simulation;Solid;Spinal Puncture;success;surgery outcome;symptomatic improvement;Symptoms;Syndrome;Techniques;Technology;Testing;Tissues;Treatment outcome;viscoelasticity;Work

PROJECT_TITLE: Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Timely diagnosis of dementia in primary care enables primary care providers (PCPs) to identify treatment opportunities and to support patients and their caregivers in planning ahead and making decisions about safety, medications, management of comorbid conditions, and caregiving. Yet, missed and delayed diagnosis of dementia in primary care is a persistent problem and is especially common among racial/ethnic minorities. This study uses comparative ethnography within primary care practices to generate data from people with dementia, caregivers, primary care teams, and health systems and policy leaders and will use findings to develop intervention targets to improve dementia diagnosis within the primary care workforce.

PI_NAMEs: SIDEMAN, ALISSA BERNSTEIN (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acute;Address;Affect;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Attitude;Awareness;Caregivers;caregiving;Caring;Clinical;Cognitive;Communication;Communities;comorbidity;comparative;Data;Decision Making;Dementia;dementia care;Detection;Development;Diagnosis;Diagnostic;Disease;Disparity;Economically Deprived Population;Equity;ethnic minority;Ethnic Origin;Ethnography;Event;experience;follow-up;Functional impairment;Future;Goals;health disparity;health organization;Health Policy;Health system;Healthcare;Impaired cognition;improved;Individual;innovation;Institution;Insurance;Intervention;Interview;Knowledge;Language;Leadership;lens;multidisciplinary;neurocognitive disorder;older adult;Older Population;Outcome;Patients;Persons;Pharmaceutical Preparations;Physician Executives;Policies;Population Heterogeneity;preference;prevent;Primary Care;primary care practice;primary care provider;primary care setting;primary care team;Process;Protocols documentation;Provider;racial diversity;racial minority;Research;Resource-limited setting;Resources;Risk;Rural;rural area;Safety;safety net;Scientist;Self Efficacy;Site;social;social stigma;socioeconomic disadvantage;Specialist;Symptoms;System;therapy development;Time;Translations;United States National Institutes of Health;urban area

PROJECT_TITLE: Building Primary Care Workforce Capacity in the Dementia Diagnostic Process

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project narrative The formation of functional sperm is key to reproduction and its failure leads to infertility in men. Key aspects of spermatogenesis is conserved and very similar between the fruitfly Drosophila and humans. We have identified a novel and unanticipated role of Rho kinase and its target Combover in spermatogenesis, the study of which is part of this application that thus will have wide implications for male fertility.

PI_NAMEs: JENNY, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Actins;Address;Affect;Binding;Biological Assay;Cell Culture Techniques;Cell division;Cell membrane;cell motility;Characteristics;Complex;Couples;Cytoplasm;Cytoskeleton;Data;Defect;Development;Diploidy;Disease;Down-Regulation;Drosophila genus;Encapsulated;Ensure;Epithelium;Failure;Family;Fertility;flotillin;fly;Gametogenesis;gastrulation;Genetic;Germ Cells;Germ Lines;Giant Cells;Growth;Haploidy;Human;In Vitro;in vivo;Infertility;male;male fertility;Mammals;Maps;member;Membrane;Membrane Proteins;men;Microtubules;Mind;Modeling;Morphogenesis;Movement;Multiprotein Complexes;mutant;Neoplasm Metastasis;Neural tube;novel;Oogenesis;Organelles;Organism;Pathway interactions;Pattern;Phase;Phenotype;Phosphorylation;Phosphorylation Site;Physical condensation;Process;programs;protein complex;Proteins;Regulation;Reproduction;Resolution;response;Rho-associated kinase;Role;Shapes;Signal Transduction;Somatic Cell;sperm cell;Sperm Tail;Spermatids;Spermatogenesis;Spermiogenesis;Sterility;Structure;Testing;Testis;Tissues;ubiquitin-protein ligase;Up-Regulation

PROJECT_TITLE: The role of Rok and its substrate Cmb the male germline

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project narrative The cognitive processes of learning, decision-making and memory rely on similar neural computations, yet are seldom studied together within individual. We will combine behavioral and functional MRI experiments to characterize these processes within individual, and to identify links between individual neurobehavioral profiles and symptoms of anxiety and stress-related disorders. Such detailed profiling will facilitate development of individually tailored interventions.

PI_NAMEs: LEVY, IFAT  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Amygdaloid structure;Animals;Anxiety;anxiety symptoms;associated symptom;Basic Science;Behavior;Behavioral;behavioral study;Brain;Characteristics;Classification;Clinical;cognitive process;Computer Models;Corpus striatum structure;Data;Decision Making;design;Development;Dimensions;Economics;Environment;experimental study;Functional Magnetic Resonance Imaging;Future;General Population;Goals;Harm Reduction;Human;Individual;Individual Differences;Intervention;Learning;Link;Location;maladaptive behavior;Measures;Memory;men;Mental disorders;Mental Health;Methodology;Nature;Negative Valence;neural;neural correlate;neural patterning;neurobehavioral;neuromechanism;novel;Organism;Outcome;Parietal;Participant;Pattern;Positive Valence;Process;Psychopathology;Punishment;Research;Research Domain Criteria;Rewards;Sampling;Stress;stress related disorder;stress symptom;symptomatology;Symptoms;Techniques;Time;Uncertainty;Update;Variant;Woman;Work

PROJECT_TITLE: Neural computations of learning, decision-making and memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Rehabilitation;Stroke

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: For millions of stroke survivors, reading deficits represent a significant impediment to independence, reducing an individual’s ability to return to work and the overall quality of life. The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which aerobic exercise training will be used as an adjuvant to a targeted reading treatment. This approach is expected to increase cerebral circulation and help to rebuild and strengthen the damaged phonological neural networks. Through this combinatory approach, the study aims to enhance the reading and language improvements seen with existing treatments.

PI_NAMEs: BOUKRINA, OLGA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adjuvant;Aerobic;Aerobic Exercise;Affect;American;Aphasia;Area;auditory comprehension;Blood Vessels;Brain;brain dysfunction;Brain region;Cerebrovascular Circulation;Chronic;Cognitive;cognitive function;Communication impairment;Competence;effective therapy;Effectiveness;effectiveness testing;Evidence based treatment;Exclusion;Exercise;exercise training;functional improvement;Goals;Hour;Hybrids;hypoperfusion;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;Language;Language Development;Language Disorders;language outcome;language processing;Language Tests;Left;Lesion;Life;Light;Maps;Measures;Mission;Modality;Motor;MRI Scans;Names;National Institute on Deafness and Other Communication Disorders;neural;neural network;Neurobiology;neurological rehabilitation;neuromechanism;Neuronal Plasticity;novel;Nutrient;Orthography;Outcome;Oxygen;Parietal Lobe;Participant;Performance;phonology;Population;post stroke;primary outcome;Process;programs;Quality of life;Randomized;Randomized, Controlled Trials;Reading;reading ability;reading difficulties;Reading Disorder;Recovery;remediation;Research;Rest;Scanning;Short-Term Memory;skills;sound;Speech;Standardization;Stretching;Stroke;stroke patient;stroke recovery;stroke survivor;stroke-induced aphasia;Structure;Testing;Time;treatment effect;Treatment Effectiveness;Treatment outcome;Vascular blood supply;Work

PROJECT_TITLE: Improving Reading Competence in Aphasia with Combined Aerobic Exercise and Phono-Motor Treatment

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related;Women's Health Research

ORG_CITY: MEMPHIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Vulvovaginal candidiasis is an exceedingly common infection of the reproductive tract of otherwise healthy women that is caused by the fungus Candida albicans and significantly impacts quality-of-life. The research in this proposal is aimed to identify how natural variation in the fungal toxin candidalysin, a key determinant of disease, alters vaginal inflammation. We also aim to dissect pathological host responses to Candida and candidalysin and identify novel therapeutic interventions that may inhibit both harmful inflammation and fungal growth to improve resolution of disease symptoms.

PI_NAMEs: PETERS, BRIAN M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Age;Alanine;Alleles;Amino Acids;anti-fungal agents;Anti-Inflammatory Agents;Antigen-Antibody Complex;Attenuated;Automobile Driving;Award;Biological Assay;Bone Marrow;Candida;Candida albicans;cell injury;cell type;Cells;Chemicals;Chimera organism;Clinical;Clinical Management;Code;Collection;comorbidity;conditional knockout;cytokine;Data;Defect;Disease;Docking;Edema;Endothelium;Epithelial Cells;Epithelium;experimental study;Female of child bearing age;fitness;Fungal Drug Resistance;Fungal Peptides;fungus;Growth;Hand;Health;hormone therapy;Human;Immune;Immune response;Immunization;immunodeficiency;immunopathology;improved;in silico;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Interleukin-1 Receptors;Intervention;Ligands;Link;Maps;Mediating;Mediator;member;Modeling;Molecular;Molecular Target;monocyte;Mus;Mycoses;Mycotoxins;neutrophil;novel;novel therapeutic intervention;oral infection;Outcome;Pain;Pathogenesis;pathogenic fungus;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Peptide Initiation Factors;Peptides;pharmacophore;Phenotype;Play;Protein Isoforms;Proteins;Publishing;Quality of life;Receptor Signaling;recruit;recurrent infection;reproductive;Reproductive Tract Infections;Research;Resolution;response;Role;scaffold;Scanning;screening;Series;Signal Transduction;Site;small molecule;standard of care;Sterility;Structure;Structure-Activity Relationship;Symptoms;Systemic infection;T-Lymphocyte;Testing;Tissues;Toxin;vaccination strategy;vaccine candidate;Vagina;vaginal infection;vaginal mucosa;Vaginitis;Validation;Variant;Virulence;Vulvovaginal Candidiasis;Woman

PROJECT_TITLE: Candidalysin: a key mediator of Candida vaginitis immunopathology

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Starburst amacrine cells (SACs) are at the root of the direction selective response and optokinetic eye movements, and defects in SAC function can lead to nystagmus. This study will comprehensively dissect the function of a key transcription factor that mediates SAC somatic positioning and circuit connection. This line of research is important not only for uncovering the principles of circuit formation but also for providing insight into a neuronal replacement strategy that can be potentially achieved through manipulating a key transcription factor to rescue visual defects.

PI_NAMEs: PENG, YI-RONG  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Affect;Alleles;ATAC-seq;Axon;Biological Assay;Blindness;Cell Physiology;cell type;Cells;cholinergic;conditional knockout;Data;Defect;Dendrites;design;Development;early embryonic stage;Electroporation;Embryo;Eye Movements;ganglion cell;Ganglion Cell Layer;Gene Expression;Genetic;genetic manipulation;Goals;Image;Impairment;in utero;Inner Nuclear Layer;Inner Plexiform Layer;insight;Interneurons;Knock-out;Label;Measures;Mediating;migration;Modeling;Molecular;Morphology;Neonatal;nerve supply;Nervous System;neuronal replacement;Neurons;Nuclear;Outcome;overexpression;Pathologic Nystagmus;Physiological;Positioning Attribute;postnatal development;postsynaptic;Research;response;Retina;Role;segregation;selective expression;Somatic Cell;Specific qualifier value;Specificity;starburst amacrine cell;Stratification;Synapses;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Vision;Visual;Visual impairment

PROJECT_TITLE: Transcriptional Control of Neuronal Position and Connection in the Retina


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Our lab is advancing knowledge of how human genetic variation influences the production of red blood cells and a special form of hemoglobin called fetal hemoglobin (HbF), which can help in conditions like sickle cell disease and other forms of anemia. Using state-of-the-art genetic tools, we aim to uncover the complex network of genes that control red blood cell production and HbF levels, which could lead to new, innovative treatments for blood diseases. This research marks a key step towards turning our genetic understanding into tangible clinical solutions for challenging blood disorders.

PI_NAMEs: SANKARAN, VIJAY GANESH (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Adenine;Affect;Anemia;base editing;beta Thalassemia;Biological Assay;blood treatment;Cells;Chromatin;Clinical;clinical development;combinatorial;Complex;Congenital Anemia;Cytosine;Development;Disease;Dissection;Elements;Erythrocytes;Erythropoiesis;Fetal Hemoglobin;GATA1 gene;gene network;Genes;Genetic;Genetic Population Study;Genetic study;genetic variant;Genetic Variation;Genome;Genomics;Goals;Grant;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemoglobin;Hemoglobin concentration result;Hemoglobinopathies;Human;Human Genetics;innovation;insight;Intervention;Investigation;Knowledge;Maps;Methodology;Mutation;novel therapeutic intervention;Nucleotides;Phenotype;Process;Production;Regulation;Regulatory Element;Reporter;Research;Resolution;Role;Sickle Cell Anemia;Single Nucleotide Polymorphism;Techniques;Therapeutic;tool;transcription factor;Variant;Vision

PROJECT_TITLE: Systematic Genetic Dissection of Human Erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Obesity;Pain Research;Peripheral Neuropathy;Prevention

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Chronic pain afflicts millions of people, and many treatment options have serious side effects. A diet-based approach has shown promise in regulating pain signaling mechanisms and decreasing pain. The purpose of this grant is to develop a clinical trial to test whether and how this diet-based approach reduces pain in adults with chronic low back pain.

PI_NAMEs: FAUROT, KETURAH RUTH;ZAMORA, DAISY  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acids;Adult;Advisory Committees;Analgesics;Anti-Inflammatory Agents;antinociception;Applications Grants;Back Pain;Biochemical;Biochemical Process;Biological;Biological Markers;Blood;Caring;Chronic;Chronic Care;Chronic Daily Headaches;Chronic Headaches;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Research;clinical trial implementation;Clinical Trials;Common Data Element;Complex;Consent Forms;Data;data infrastructure;data management;Databases;design;Development;diaries;Diet;Diet Modification;dietary;dietary control;Dietary Intervention;Docosahexaenoic Acids;efficacy testing;Eicosapentaenoic Acid;Electronics;Elements;Fatty Acids;Fatty Change;Food;food preparation;Food Supply;Frequencies;Funding;Goals;Grant;Guidelines;Headache;high reward;Human;improved;Inflammation;Inflammatory;Information Systems;insight;Intake;Intervention;Laboratories;Linoleic Acids;Low Back Pain;Manuals;Mediator;Migraine;Modeling;Modification;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neurons;Nociception;Non-Steroidal Anti-Inflammatory Agents;Nutrient;nutrition;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Pain;Pain intensity;pain reduction;pain signal;Participant;Pathogenesis;Pathway interactions;Persistent pain;Persons;Pharmaceutical Preparations;pilot trial;Plasma;Play;Polyunsaturated Fatty Acids;Population;Pre-Clinical Model;pre-clinical research;preclinical study;Preparation;Procedures;Property;Publishing;Radiculopathy;Randomized;Randomized, Controlled Trials;Reducing diet;Regulation;Reporting;Research;Research Design;Risk;Safety Management;Secure;Series;side effect;Signal Transduction;systems research;Target Populations;Testing;Time;Translating;treatment as usual;treatment response;trial planning;United States Department of Agriculture;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Dietary alteration of n-6 and n-3 fatty acids for chronic low back pain

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BOWLING GREEN

ORG_DEPT: BIOLOGY

ORG_NAME: WESTERN KENTUCKY UNIVERSITY

ORG_STATE: KY

PHR: Project Narrative This grant will fund the purchase of a ChemiDoc MP Imaging System, an essential equipment routinely used for imaging and quantifying nucleic acids and proteins in gels and western blots, which is necessary to complete various funded studies and fulfill degree requirements for biology majors. The requested instrument will fulfill the imaging needs of four research laboratories engaged in a wide area of research ranging from microbiology, cell proliferation and tumor metastasis. Furthermore, this imager will support learning objectives of five different biology courses and enrich the educational experience of undergraduate students from multiple departments with different majors.

PI_NAMEs: BANGA, SIMRAN  (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: 18 year old;Biochemistry;Biological Models;Biological Sciences;Biology;Biomedical Research;Biotechnology;Communities;Computers;Data;digital imaging;DNA;Documentation;Education;Educational process of instructing;Electrophoresis;Equipment;experience;experimental analysis;Functional Imaging;Funding;Funding Agency;Gel;gel electrophoresis;hands-on learning;high resolution imaging;Image;imager;imaging capabilities;imaging system;instrument;Kentucky;laboratory curriculum;laboratory equipment;Laboratory Research;Learning;Manufacturer;Modernization;Molecular Biology;Population;Proteins;Research;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Running;skills;student participation;Students;Systems Analysis;teaching laboratory;Techniques;training opportunity;undergraduate student;Universities;Visualization;Western Blotting;Work

PROJECT_TITLE: Electrophoresis Imaging System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Genetics;Health Services;Prevention;Primary Health Care;Rare Diseases;Women's Health Research

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

PHR: PROJECT NARRATIVE Among the estimated one million Americans who have screened positive for specific genetic variants related to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) or Lynch Syndrome (LS), less than half are up to date on evidence-based cancer prevention measures that may increase early detection of syndrome-related cancers or prevent certain associated cancers altogether. We posit that providing clinical decision support to both patients and primary care clinicians at clinical encounters will expedite the referral of patients with HBOC or LS to subspecialists for timely cancer preventive care, thus improving quality of care and clinical outcomes of these high-risk patients. To achieve this goal, we expand an existing, effective, patient-centered clinical decision support system to identify patients who have consented to genetic testing and found to have specific gene variants related to HBOC or LS, and assess intervention impact on up-to-date cancer prevention care, shared decision making, and patient self-efficacy in managing hereditary cancer risk.

PI_NAMEs: O'CONNOR, PATRICK J (contact)

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: Adult;American;Attitude;BRCA1 gene;BRCA2 gene;cancer diagnosis;cancer genetics;cancer prevention;cancer risk;Caring;Centers for Disease Control and Prevention (U.S.);Chronic;Clinic;Clinical;clinical decision support;Clinical Decision Support Systems;clinical encounter;Cluster randomized trial;Communication;Consent;Data;Early Diagnosis;Electronic Health Record;Eligibility Determination;Ethnic Origin;evidence base;follow-up;genetic counselor;genetic testing;genetic variant;Genomics;Goals;Guidelines;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;Heterogeneity;high risk;improved;indexing;Individual;Intervention;intervention effect;Knowledge;Laboratories;Malignant Neoplasms;Measures;MSH2 gene;MSH6 gene;National Comprehensive Cancer Network;Nature;Newly Diagnosed;Oncologist;Oncology;Online Systems;Other Genetics;Outcome;Pathogenicity;Patient Care;patient oriented;Patient-Focused Outcomes;Patients;PMS2 gene;Positioning Attribute;prevent;Prevention Guidelines;Prevention Measures;Preventive care;Primary Care;primary care clinic;primary care clinician;primary care setting;Procedures;Public Health;Quality of Care;Questionnaires;Race;Randomized;randomized trial;Recommendation;Reporting;secondary analysis;Self Efficacy;sex;shared decision making;Source;success;Surveys;Syndrome;System;TACSTD1 gene;Testing;Time;treatment as usual;Variant;virulence gene;Visit

PROJECT_TITLE: Randomized Trial to Improve Care of Patients with Hereditary Cancer Syndromes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Base damage by alkylating agents is a commonly encountered type of DNA damage produced by environmental agents as well as by cancer chemotherapeutics. Our recent work indicates that these agents also induce innate immune signaling, in a manner that depends not on DNA but on RNA damage. This proposal seeks to understand the cellular and molecular mechanism of this signaling and its connection to cancer therapy.

PI_NAMEs: MOSAMMAPARAST, NIMA  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Alkylating Agents;Alkylation;Apoptosis;base;Biochemical;Biochemistry;cancer therapy;cell injury;Cell Survival;Cells;Chemotherapy-Oncologic Procedure;Collaborations;Complex;Crosslinker;Cytoplasm;Data;DNA;DNA Damage;DNA receptor;DNA Repair;Effectiveness;Engineering;Environment;environmental agent;Enzymes;Event;helicase;Homeostasis;Immune signaling;immunogenic;immunoregulation;Innate Immune Response;inorganic phosphate;irradiation;Knowledge;Link;Malignant Neoplasms;Mediating;Mediator;Metals;Methylation;Modeling;Modification;Molecular;mRNA Precursor;neoplastic cell;Normal Cell;Nuclear;Nuclear RNA;nuclease;Pathway interactions;Pattern;Periodicity;Process;Proteins;Quality Control;receptor;reconstitution;recruit;Repair Complex;repaired;response;Ribonucleases;RNA;RNA I;RNA Processing;Role;Signal Pathway;Signal Transduction;Spliceosomes;Stress;Structure;Testing;Therapeutic;treatment response;tumor;unpublished works;Virus Diseases;Work

PROJECT_TITLE: An RNA-Dependent Innate Immune Response Pathway to Base-Damaging Chemotherapeutics

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE There is urgent need to understand the shared genetic architecture and biological pathways of cardiometabolic disease risk factors. This proposal aims to leveraging mega-scale genomics datasets with individual- and meta- level data, and state of the field analysis tools. We anticipate that our comprehensive approach to understand cardiometabolic health profile components and their role in disease endpoints will bring us several steps closer towards identifying novel molecular targets.

PI_NAMEs: SALEM, RANY  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adult;adverse outcome;African;Alcohol consumption;Anatomy;Asian ancestry;Biological;Biology;Blood Pressure;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Central obesity;Classification;Clinical;Cluster Analysis;Coronary Arteriosclerosis;Coronary heart disease;Data;Diet;Disease;Disease susceptibility;disorder risk;East Asian;Environment;Ethnic Population;European;fasting glucose;Fatty acid glycerol esters;Functional disorder;gene environment interaction;Genes;Genetic;genetic analysis;genetic architecture;Genetic Variation;genome wide association study;genome-wide;genomic data;Genomics;Goals;Health;hemodynamics;Heritability;Heterogeneity;High Density Lipoprotein Cholesterol;high risk;Hispanic;Hypertension;Individual;Inherited;insight;Insulin Resistance;Investigation;Kidney Diseases;Label;LDL Cholesterol Lipoproteins;Life Style;lifestyle factors;Link;Lipids;Liver diseases;low density lipoprotein triglyceride;Measures;Mediation;Mendelian randomization;Metabolic;Metabolic syndrome;modifiable risk;Molecular Target;Morbidity - disease rate;mortality;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Pacific Islander;Pathway interactions;Pattern;Physical activity;Play;pleiotropism;Predisposition;racial population;Risk;Risk Factors;risk sharing;risk stratification;risk variant;Role;Sample Size;sex;Smoking;South Asian;Stroke;Syndrome;Testing;tool;trait;Triglycerides;waist circumference;Work

PROJECT_TITLE: Genetic investigations of cardiometabolic disease: pleiotropy, gene x environment and causal inference analyses

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose to investigate the neural circuit mechanism whereby serotonin regulates food intake. We will use a multidisciplinary approach to identify the specific subset of serotonin neurons controlling satiety and determine their function in behaving mice. These studies will provide the scientific basis for the development of new serotonin-based weight loss therapies.

PI_NAMEs: LIU, CHEN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adult;Agonist;Alleles;Anabolism;Appetite Depressants;Appetite Regulation;Appetite Stimulants;ART protein;Body Weight;Brain;calcium indicator;Coupled;Desire for food;Development;Diet;diet-induced obesity;dorsal raphe nucleus;Drug Targeting;Eating;Energy Metabolism;Enzymes;feeding;Food deprivation (experimental);Genetic;genetic approach;Heart Valve Diseases;Heterogeneity;Homeostasis;Hunger;Hypothalamic structure;in vivo;in vivo calcium imaging;interdisciplinary approach;Mediating;Messenger RNA;Midbrain structure;Migraine;Mus;neural circuit;Neurons;novel;Obese Mice;Obesity;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiological;pill;Play;postsynaptic;presynaptic;Pro-Opiomelanocortin;receptor;receptor expression;Recombinant adeno-associated virus (rAAV);reduced food intake;Regulation;Reporter;Reporting;response;Role;Satiation;selective expression;serotonergic regulation;Serotonin;Serotonin Agonists;serotonin receptor;side effect;Signal Transduction;Source;Structure of nucleus infundibularis hypothalami;Synapses;System;tool;triptans;weight loss intervention;Work

PROJECT_TITLE: Deconstruct Raphe Serotonin Neurons that Regulate Satiety

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The study of genes and gene products that allow, when altered, the emergence of supernormal capacities fulfills the mission of the National Institutes of Health by enabling the future development of approaches that could reproduce this augmentative influence or action. Understanding and modifying how such genes work harbors potential to enhance performance (in this case, mouse motor performance) and this might ultimately counteract a variety of neurological disorders that impair mobility.

PI_NAMEs: PASCUAL, JUAN M. (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adenoviruses;Animals;antagonist;Area;behavior test;Behavioral;Biological Assay;Brain;cancer type;Cells;Cerebellum;Cerebral cortex;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Conceptions;Data;Dependovirus;Development;Disease;DNA;DNA Folding;DNA Repair;Embryo;Endowment;Ethylnitrosourea;Exhibits;experience;Fibroblasts;Fire - disasters;functional gain;Future;G-Quartets;GDF8 gene;Gene Expression;gene product;Genes;Genetic;Genetic Transcription;Genomics;Goals;granule cell;Health;Injections;Laboratory mice;Learning;Locomotion;Longevity;loss of function;Malignant Breast Neoplasm;Mediating;Mediation;Mediator;Messenger RNA;Mission;Mobility decline;Motion;Motor;motor disorder;motor impairment;motor learning;motor recovery;Movement;Mus;Muscular Dystrophies;mutant;Mutant Strains Mice;Mutate;Mutation;Nervous System;Nervous System Disorder;Neurological disability;neurophysiology;Organism;Outcome;overexpression;Performance;Persons;pharmacologic;Phenotype;Point Mutation;Population;Predisposition;Primates;Prosencephalon;protein expression;Purkinje Cells;Radiation;Radiation Induced DNA Damage;Regulation;Resistance;Rest;screening;Spinal Cord;Spinal Muscular Atrophy;stem;Stroke;stroke recovery;Synapses;synaptic function;Synaptic Transmission;System;Testing;Time;Tissues;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;treadmill;United States National Institutes of Health;Up-Regulation;Video Recording;Work

PROJECT_TITLE: Mechanisms of Motor Superperformance

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


PHR: Project Narrative Voltage-gated ion channels (VGICs) are the targets of drugs used to treat hypertension, arrhythmia, pain, epilepsy, and mood disorders. Our work aims to understand the molecular architecture that underlies VGIC function and modulation and how such complex molecules are assembled. Such understanding has direct relevance for development of more efficacious treatments of nervous system and cardiovascular disorders.

PI_NAMEs: MINOR, DANIEL L (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Affect;Architecture;Arrhythmia;autism spectrum disorder;Binding;Binding Proteins;Binding Sites;Biochemical;Biogenesis;Biological;Biological Assay;Biophysics;Brain;C-terminal;Calcium Channel;Cardiovascular Diseases;Cardiovascular system;Cell Line;Cell surface;Cells;chronic pain;Client;Complex;Congestive Heart Failure;Cryoelectron Microscopy;Dependence;Development;Disease;Dissection;Docking;Drug Targeting;Drug usage;efficacious treatment;Electrophysiology (science);Elements;endoplasm;Endoplasmic Reticulum;Epilepsy;Family;Foundations;G protein coupled receptor kinase;Goals;Heart;High voltage activated calcium channel;Human;Hypertension;insight;interdisciplinary approach;Investigation;Ion Channel;Ion Channel Gating;Knock-out;Knowledge;Length;Life Cycle Stages;Macromolecular Complexes;Maps;Mass Spectrum Analysis;Measurement;member;Membrane;Membrane Proteins;Molecular;Molecular Chaperones;Molecular Probes;Mood Disorders;Movement;Mutagenesis;mutant;Mutation;Nature;Nervous System;Oranges;Pain;particle;Pharmaceutical Preparations;Physiology;Preparation;protein complex;Protein Complex Subunit;Protein Engineering;Protein Isoforms;Proteins;Regulation;Resolution;response;Role;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Site;Structure;Subgroup;Surface;Surveys;Tail;Therapeutic Agents;trafficking;voltage;voltage gated channel;Work

PROJECT_TITLE: Structural Studies of Ion Channel Assembly and Signaling Complexes

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CARBONDALE

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE

ORG_STATE: IL

PHR: PROJECT NARRATIVE Flow cytometers are vital instruments used in biomedical research, capable of characterizing immune cell populations or quantifying cellular phenotypes with fluorescent dyes. This proposal seeks to obtain a FACSymphony A1 Laser Cell Analyzer with high sensitivity and detection capacity that will assist in the characterization and quantification of cells. This instrument will support SIU investigators’ current and future research programs and provide training opportunities for undergraduate and graduate biomedical trainees.

PI_NAMEs: KONJUFCA, VJOLLCA H (contact)

PROJECT_TERMS: Biomedical Research;bridge program;Cancer Biology;Cell Size;Cells;college;Color;Communicable Diseases;community college;cytokine;Detection;detector;Education;Electronics;Equipment;Experimental Designs;Fiber Optics;Flow Cytometry;Fluorescent Dyes;Fluorochrome;Funding;graduate student;Illinois;Immunology;improved;instrument;instrumentation;laboratory curriculum;Lasers;Light;light emission;medical schools;Mentors;Molecular Biology;Noise;optical emission;Optics;particle;particle detector;Population;programs;Research;Research Personnel;Signal Transduction;Source;student training;System;Technology;Tissues;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;university student;Viola

PROJECT_TITLE: Multicolor flow cytometer with a particle detector.


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Hypertension;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE: We investigate the innate immune mechanism underlying the activated circulating monocyte in pulmonary arterial hypertension (PAH) and its pivotal role in orchestrating adverse vascular remodeling through its derivatives, the monocyte derived dendritic cell (MO-DC) and the monocyte derived macrophage (MO-MØ). Our studies include bio-fabricated vascular tubes with monocytes and vascular cells derived from patients with BMPR2 mutations as well as transgenic rat models of PAH. We apply CRISPR screens to determine how mutations associated with PAH share pathways of monocyte activation that lead to pathological MO-DC and MO-MØ, and how these features can be addressed in developing new therapies.

PI_NAMEs: NICOLLS, MARK ROBERT;RABINOVITCH, MARLENE  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adhesions;Apoptosis;Arachidonate 5-Lipoxygenase;Autoimmunity;B-Lymphocytes;Blood Vessels;BMPR2 gene;Cell Differentiation process;Cell Line;Cell Proliferation;Cells;Chromosome Mapping;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Data;Deacetylase;Dendritic Cells;derepression;DNA Repair;Elements;Endogenous Retroviruses;Endothelial Cells;endothelial stem cell;Endothelium;Enterochromaffin Cells;Evolution;Female;Functional disorder;gene regulatory network;Genes;genome wide screen;genome-wide;high throughput screening;Homing;Human;Impairment;improved;induced pluripotent stem cell;Inflammation;Inflammatory;innate immune mechanisms;Innate Immune Response;Interferon Type II;Interferons;Intervention;Invaded;Label;Latex Bead;Link;Macrophage;male;Messenger RNA;migration;Modeling;monocyte;Muscle Cells;mutant;Mutate;Mutation;novel;novel therapeutics;Nude Rats;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Phagocytosis;Phenotype;Phosphorylation;Physiological;Play;pluripotent stem cell differentiation;prevent;progenitor;pulmonary arterial hypertension;Pulmonary artery structure;pulmonary vascular remodeling;Rat Transgene;Rattus;recruit;response;Rodent;Role;Severe Acute Respiratory Syndrome;Sex Bias;shear stress;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;STAT1 gene;targeted treatment;Technology;Transcriptional Activation;transcriptome;transcriptomics;Transfection;Tube;Up-Regulation;Vascular remodeling;Viral;X Chromosome

PROJECT_TITLE: BMPR2, Monocytes and Macrophages in Pulmonary Artery Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The revised R01 proposal aims to establish a diverse cohort of primary congenital hydrocephalus (CH) patients, with a particular emphasis on non-European populations, to ensure broader applicability and inclusivity of our findings. Through the integration of genomics, phenomics, and neuroimaging data, we will comprehensively characterize germline and somatic variants, explore temporal expression patterns of CH risk genes across various cell types, enhance diagnostic precision, and unravel genotype-phenotype correlations. Furthermore, the development of the HYDRO-Seq Genome Browser, integrated with the WashU Epigenome Browser, will streamline data analysis and enable seamless sharing of patient genetic and phenotypic information.

PI_NAMEs: JIN, SHENG CHIH  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;Age;Algorithms;Brain;brain surgery;brain tissue;Candidate Disease Gene;Catalogs;cell type;Cerebrospinal Fluid;Cerebrospinal fluid shunts procedure;Child;Classification;Clinical;Clinical Data;cohort;Cohort Studies;Congenital Hydrocephalus;Data;Data Analyses;data archive;data sharing;data standards;Development;diagnostic accuracy;Disease;Electronic Health Record;Embryo;Ensure;epigenome;exome sequencing;experience;experimental study;Failure;Fluid Balance;gene discovery;Gene Expression;Gene Frequency;General Hospitals;Genes;Genetic;Genetic Heterogeneity;Genetic study;genetic variant;Genome;genome browser;genome sequencing;genomic data;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Guidelines;Human;Hydrocephalus;image processing;improved;insight;Left;Life;Link;Massachusetts;Molecular;Morbidity - disease rate;mosaic;multidisciplinary;Mutation;Neurodevelopmental Disability;Neuroepithelial;neuroimaging;Neurosciences;neurosurgery;novel;Ontology;open data;Operative Surgical Procedures;Outcome;Parents;Pathogenesis;Pathogenicity;Pathway interactions;Patient Recruitments;Patients;Pattern;Pediatric Hospitals;Pediatric Neurology;Penetrance;personalized diagnostics;phenomics;Phenotype;phenotypic data;Population;proband;Procedures;Process;protein protein interaction;Quality Control;recruit;Research;Risk Factors;risk variant;RNA Splicing;Role;Sample Size;Single Nucleotide Polymorphism;Somatic Mutation;Standardization;stem cells;Testing;therapeutic development;Tissues;Transcript;transcriptome sequencing;transcriptomics;transmission process;Untranslated RNA;Variant;Ventriculostomy;Visualization;whole genome;Work

PROJECT_TITLE: Molecular and cellular characterization of congenital hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Pain Research;Physical Activity;Rehabilitation;Telehealth;Women's Health Research

PHR: PROJECT NARRATIVE The proposed research addresses the urgent need for more effective, accessible, and patient-centered treatment strategies for women with chronic pelvic pain, as a common and debilitating pain syndrome. If successful, this research may pave the way for women suffering from chronic pelvic pain throughout the United States to practice yoga to improve their pain-related functioning in home and community settings, while reaping other potential benefits for their long-term health.

PI_NAMEs: GIBSON, CAROLYN ;HUANG, ALISON  (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Address;Adherence;Adult women;Affect;Anxiety;anxious;Awareness;Back;Behavior;biopsychosocial;biopsychosocial factor;Breathing;California;Caring;central pain;chronic pain;chronic pelvic pain;Client satisfaction;Clinical;Clinical Treatment;Cognition;Collaborations;Communities;community setting;comorbidity;Complementary therapies;Complex;cost;debilitating pain;deconditioning;design;Disease;Educational process of instructing;efficacy evaluation;efficacy trial;Etiology;Evaluation;Exercise;experience;Exposure to;feasibility trial;Female;Funding;Health;Health care facility;Health Personnel;Home;improved;Individual;Inflammation;Instruction;interpersonal trauma;Intervention;Location;Maintenance;Mediating;Mediator;men;Mental Depression;mental practice;mindfulness;Modality;Modeling;Moods;Muscle;Musculoskeletal;Neurologic;Organ;Pain;Pain intensity;Pain interference;pain outcome;pain-related disability;patient engagement;patient oriented;patient safety;Pelvic floor dysfunction;Pelvic floor structure;Pelvic Pain;Pelvis;perceived stress;Performance;Personal Satisfaction;Physical activity;physical conditioning;Physical Function;physical inactivity;Physiology;pilot trial;Posture;primary outcome;Process;programs;psychologic;Quality of life;Randomized;randomized trial;recruit;Recurrent pain;Relaxation Techniques;remote delivery;Research;Research Support;response;Role;Safety;satisfaction;Self Management;Sex Behavior;Sex Functioning;Sexual Dysfunction;sexual trauma;Sleep;Social isolation;Specialist;Stress;Stretching;Structure;Supervision;Syndrome;Therapeutic;Time;Trauma;Travel;treatment strategy;United States;videoconference;virtual platform;Visceral;Visit;willingness;Woman;women's outcomes;Women's trial;Yoga

PROJECT_TITLE: The National Program to Overcome Pelvic Pain studY (POPPY)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project narrative.  As survival rates for pediatric brain cancers and leukemias have risen strikingly over the last several de- cades, the US survivor population is steadily growing. Unfortunately, the treatments that make this possible cause brain damage, and the nature of this damage is poorly understood, hampering its treatment. Our proposal tests the hypothesis that a major locus of radiotherapy-mediated neuronal damage is the plasma membrane u- sing modern techniques and tests potential therapies for these sequelae to inform new clinical interventions for improving survivorship in cancer survivors and others exposed to radiation.

PI_NAMEs: DUMAN, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Achievement;Acute;Address;Adult;Affect;aging related;Alleles;Alzheimer's Disease;Animal Behavior;Animal Model;Apolipoprotein E;Astrocytes;Behavioral;Bioinformatics;Biological;Biophysics;Brain;Brain Injuries;Brain Neoplasms;Cancer Patient;Cancer Survivor;cancer therapy;Caregivers;cell injury;Cell membrane;Cell Membrane Permeability;Cells;Cessation of life;chemotherapy;Child;Childhood Brain Neoplasm;childhood cancer survivor;Childhood Malignant Brain Tumor;Cholesterol;cholesterol biosynthesis;Clinical;Clinical Data;Cognitive;Cognitive deficits;Cognitive Therapy;combat;Cytoplasm;Cytoplasmic Granules;Data;Dendrites;Dendritic Spines;dentate gyrus;Diagnosis;DNA Damage;Epigenetic Process;Event;excitatory neuron;Excitatory Synapse;Exhibits;Exposure to;Gene Expression;genetic variant;Genotype;Glutamate Receptor;Goals;Health;Hippocampus;Homeostasis;Hour;Human;Impaired cognition;improved;in vivo;Injury;insight;interdisciplinary approach;Intervention;Knowledge;leukemia;leukemia treatment;lipid metabolism;lipidome;Lipids;Lipoprotein (a);Lipoproteins;Long-Term Survivors;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;Membrane Lipids;Mitochondria;Modernization;Molecular;Mood Disorders;Morphology;multidisciplinary;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nature;neglect;nerve stem cell;Neurobehavioral Manifestations;Neurocognitive;neurogenesis;Neuronal Differentiation;Neurons;Neurosciences;non-genetic;novel;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;pharmacologic;Population;postmitotic;postnatal;prevent;Process;prophylactic;Protocols documentation;Quality of life;Radiation;Radiation induced damage;Radiation therapy;Radiation-Induced Change;radioresistant;rational design;Reporting;Research;response;Risk;Risk Factors;Role;Rupture;Schedule;Signal Transduction;Site;Societies;Suicide attempt;Surface;Survival Rate;Survivors;survivorship;Synapses;Synaptic plasticity;Targeted Radiotherapy;Techniques;Testing;theories;Therapeutic;Therapeutic Effect;therapeutic target;therapy design;Time;Translating

PROJECT_TITLE: Molecular and cellular mechanisms of neuronal damage caused by anticancer therapies

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Gene Therapy;Genetics;Hematology;Liver Disease;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE We will develop in vivo gene editing strategies to correct factor FVIII gene using lipid nanoparticles (LNPs) and CRISPR/Cas9 technology. We will first develop and optimize LNPs which can deliver ribonucleic acids into liver sinusoidal endothelial cells where natural factor VIII is predominantly generated, followed by testing in vivo gene editing strategy via LNP-mediated delivery of new CRISPR/Cas9 gene editing tools in specific hemophilia A mouse models. If successful, this novel gene therapy strategy can be translated to more permanently correct factor VIII deficiency as a personalized treatment for hemophilia A patients.

PI_NAMEs: MIAO, CAROL H (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: adeno-associated viral vector;Anabolism;base;base editor;biomaterial compatibility;Blood Coagulation Disorders;Cells;Cellular Stress;Cholesterol;clinical application;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complication;cost;CRISPR-nanoparticles;CRISPR/Cas technology;Data;design;Development;DNA;DNA Repair;dosage;Drops;Encapsulated;Endogenous Factors;endonuclease;Endothelial Cells;Endothelium;enzyme replacement therapy;Exhibits;Exons;experimental study;Factor VIII;Formulation;Gene Delivery;gene editing technology;Gene Expression;gene therapy;Gene therapy trial;gene-editing approach;Genes;Genome;Goals;Guide RNA;Hemophilia A;Hepatocyte;Human;human disease;immunodeficiency;improved;In Vitro;in vivo;in vivo evaluation;Infusion procedures;inhibitor;Injections;insertion/deletion mutation;Knock-in Mouse;Ligands;Link;lipid nanoparticle;Lipids;Liver;Mediating;Messenger RNA;Methodology;Methods;mouse model;Mus;mutant;Mutate;Mutation;nanomedicine;novel;nucleic acid delivery;Nucleic Acids;Organ;Patients;Peptides;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;Plasmids;Point Mutation;Polysaccharides;Proteins;repaired;RNA;Safety;screening;Site;Source;Specificity;System;Technology;Therapeutic Effect;Time;Toxic effect;Transgenic Mice;Translating;Viral Antibodies;Viral Genes;Viral Vector

PROJECT_TITLE: Gene Editing for Hemophilia A Treatment Using Lipid Nanoparticles

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Childhood Obesity;Clinical Research;Emergency Care;Health Services;Mental Health;Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE Students with chronic absenteeism make up 13-16% of public school students and have higher rates of asthma, diabetes, overweight/obesity, and poor mental health, which constitute major public health concerns. This study will investigate effectiveness of SBHCs as a health services care delivery model to address needs of students with chronic absenteeism and improve health equity. Results will inform development of an enhanced health system model to improve care and academic and health outcomes for children with chronic absenteeism.

PI_NAMEs: CHUNG, PAUL J;DUDOVITZ, REBECCA N (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Absenteeism;Accident and Emergency department;Address;Anxiety;Asthma;behavioral health;billing data;Biological Models;Black race;California;care fragmentation;Caring;Characteristics;Child;Child Care;Child health equity;Childhood;Chronic;Chronic Disease;community clinic;Country;Data;Data Set;Development;Diabetes Mellitus;Diagnosis;disabled students;Education;Effectiveness;electronic health data;Emergency Care;Emergency department visit;Event;experience;Fostering;Graduation Rates;Growth;Health;health assessment;Health behavior;health care availability;health care disparity;Health care facility;health care service;health care service utilization;health data;health disparity;health equity;Health Services;Health Services Accessibility;Health system;Healthcare;high risk;high school;Hospitalization;Hospitals;human centered design;improve minority health;improved;inpatient service;Instruction;insurance plan;Intervention;Latinx;Link;Los Angeles;Low income;Managed Care;marginalized population;Measures;Medicaid;Mental Depression;Mental disorders;Mental Health;Mission;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Obesity;Outcome;Overweight;Pattern;Performance;Population;Positioning Attribute;Prevalence;Primary Care;primary outcome;Process;prototype;Public Health;Reduce health disparities;Risk;Sampling;school based health center;school district;Schools;Service delivery model;Sex Behavior;social;social determinants;student participation;Students;substance use;Testing;Time;time interval;Violence;Weight;Youth

PROJECT_TITLE: Examining School-Based Health Centers as Vehicles for Health Equity among Chronically Absent Students

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Medical misinformation is a global health threat leading to devastating downstream consequences and while several medical authorities have proposed that physicians should counter patient health misinformation during a clinical encounter, no study has yet comprehensively assessed physician misinformation corrective practices and the factors that facilitate or impede correction. We use two divergent areas for which misinformation is frequently promulgated – unproven stem cell therapies and Covid-19 vaccination – (1) to evaluate physician practices correcting patient misinformation and attitudes towards adopting a priori correction strategies using individual interviews, (2) to develop and validate a new Determinants of Willingness to Correct Misinformation measure to survey a national sample of physicians, and (3) to evaluate elderly patient receptivity towards corrective information from physicians, communication comprehension, channel preferences, and affect towards receiving corrective information using online asynchronous focus groups. These studies will position our group to develop, test, and implement a misinformation correction toolkit for physicians in future research.

PI_NAMEs: MASTER, ZUBIN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accounting;Address;Adopted;Adult;Affect;Aging;aging population;American;Area;Attitude;authority;behavior change;Belief;burden of chronic illness;Cessation of life;Charge;Climate;clinical encounter;cognitive interview;Communication;Comprehension;Counseling;Country;COVID-19 misinformation;COVID-19 vaccination;COVID-19 vaccine;Data;Decision Making;design;Dimensions;efficacy testing;Elderly;Environment;evidence base;exhaustion;experience;Exposure to;Factor Analysis;Faculty;Familiarity;Family Practice;Focus Groups;Future;global health;Goals;Health;Health behavior change;health literacy;Health Personnel;Health system;Healthcare;High Prevalence;human old age (65+);Individual;instrument;Internal Medicine;Intervention;Interview;Knowledge;Language;Measures;Medical;Methods;Minority;Misinformation;novel;older patient;Outcome;Patients;Physicians;Play;Politics;poor health outcome;Positioning Attribute;preference;Primary Care Physician;Professional Role;Psychometrics;Public Health;Readiness;Religious Belief;Research;Resources;Risk;Role;Sampling;Self Efficacy;skills;social influence;social media;Source;stem cell therapy;Surveys;Terminology;Testing;Theoretical Domains framework;Time;Trust;vaccine hesitancy;Vaccinee;virtual;willingness

PROJECT_TITLE: Identifying salient factors that influence physician practices in mitigating patient misinformation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: Alzheimer's disease (AD) is the most common neurodegenerative disease, but currently there is no effective means of prevention or treatment. Characterization of genes implicated in disease pathogenesis increases our mechanistic understanding of the pathways involved thereby leading to the identification of novel biomarkers and AD animal model systems. In this proposal, we will study an extremely large and well-characterized cohorts to identify and characterize genetic regulators of sTREM2.

PI_NAMEs: CRUCHAGA, CARLOS  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid deposition;Animal Disease Models;Automobile Driving;Binding;Bioinformatics;Biological;Biological Markers;Biological Models;Biological Process;Biology;Brain;Cell surface;Cell Survival;Central Nervous System;Cerebrospinal Fluid;Clinical;Cognitive;cohort;Complex;CRISPR interference;Data;Data Set;Development;Disease;disease phenotype;disorder risk;endophenotype;ethnic difference;Event;Genes;Genetic;genetic architecture;Genetic Screening;Genetic study;genetic variant;Genomic approach;Genomics;Goals;Grant;Health;Human;human induced pluripotent stem cells;human tissue;Immune response;Impaired cognition;Individual;induced pluripotent stem cell;Inflammation;inflammatory modulation;Inflammatory Response;large datasets;Late Onset Alzheimer Disease;Link;Macrophage;Measures;Mediation;Membrane Proteins;metabolomics;Microglia;multiple omics;Myeloid Cells;Neurodegenerative Disorders;neurofibrillary tangle formation;novel;novel marker;Pathogenesis;Pathway Analysis;Pathway interactions;Phagocytosis;Plasma;Play;Predisposition;Prevention;Proteins;proteomic signature;Proteomics;rare variant;Receptor Signaling;Research;risk variant;Role;Sampling;Signal Transduction;tau Proteins;TGFBR2 gene;Tissues;trait;Transcript;transcriptomics;TREM2 gene;Variant

PROJECT_TITLE: Genetic Modifiers of TREM2 in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative: Douglas A. Mitchell, Ph.D. There are only twenty common amino acids used to produce protein. Chemical modification of is one mechanism by which Nature squeezes more functionality out of a limited set of amino acid building blocks. There are well known “post-translational” modifications, but in our field of study, which focuses on microbial natural product biosynthesis, new exotic modifications are being frequently discovered. This project will define the extent to which these new modifications are employed on larger proteins and the functional significance of those modifications.

PI_NAMEs: MITCHELL, DOUGLAS ALAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Address;Algorithms;alpha Tubulin;Alphaproteobacteria;Amides;Amines;Amino Acids;Anabolism;Antifreeze Proteins;Archaea;Bacterial Proteins;Biochemical;Biochemical Reaction;bioinformatics tool;Biological;biological adaptation to stress;Biological Process;biophysical properties;C-terminal;Carbon;Cells;Chemicals;Chemistry;Code;Coenzyme M;comparative;Consumption;copolymer;crosslink;Cyclic GMP;Cyst;Cysteine;Data;Detection;Doctor of Philosophy;Endowment;Environment;Enzymes;Escherichia coli;experience;Family;field study;Gammaproteobacteria;Gene Cluster;Generations;Genes;Genome;genome database;Genomics;Growth;in silico;In Vitro;in vivo;Insecta;interest;Left;Length;Ligation;Metals;Methane;Methanobacteria;Methods;microbial;Microbial natural product;Microbial Physiology;Microbiology;Mining;Modification;Molecular;Molecular Structure;N-terminal;Nanotubes;Natural Products;Nature;Neighborhoods;Oxidoreductase;Oxygen;Pathway interactions;Peptide Biosynthesis;peptide natural products;Peptides;Peptidyltransferase;Physiological;Positioning Attribute;Post-Translational Protein Processing;prevent;Prokaryotic Cells;Property;Protein Chemistry;protein structure;Proteins;Reporting;Research;Ribosomal Proteins;Ribosomes;Role;Route;Side;structural biology;Structure;Sulfur;Tail;Thioamides;thioether;Time;tool;Translations;Tubulin;tyrosyltubulin ligase;Up-Regulation;user-friendly;Vertebral column

PROJECT_TITLE: Enzyme Chemistry and Biological Function of RiPP-like Modifications

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Narrative Traumatic brain injury is a risk factor for cognitive impairment and dementia, such as Alzheimer’s disease and related dementias. This proposal outlines experiments designed to determine the mechanisms of how neuroinflammation, particularly microglia activation, in the thalamus drives cognitive impairment after injury. The findings will create scientific foundations to understand better the link between brain injury and subsequent cognitive impairment.

PI_NAMEs: KANO, SHINICHI  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Antibodies;Attenuated;Behavioral;Behavioral Assay;behavioral phenotyping;Brain;Brain Injuries;Brain Pathology;Brain region;Cells;Chronic;Chronic Phase;controlled cortical impact;Data;Dementia;Development;Excision;Experimental Designs;Fc Receptor;FOS gene;Foundations;Functional disorder;GAS7 gene;Generations;Genes;glial activation;Heterogeneity;Hippocampus;Histologic;Human;human imaging;hyperphosphorylated tau;imaging study;Immune;Immunologics;Impaired cognition;improved;Injections;injured;Injury;insight;Link;Long-Term Effects;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Medial;Memory impairment;memory recognition;Microglia;Modeling;Molecular;Mus;Nerve Degeneration;neural circuit;Neurobiology;neuroinflammation;Neurologic Deficit;neuron loss;Neuronal Dysfunction;neuronal survival;Neurons;neuropathology;novel;Pathology;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Play;Population;Prefrontal Cortex;prevent;Reporting;Risk;Risk Factors;Rodent;Role;Series;single nucleus RNA-sequencing;single-cell RNA sequencing;spatial memory;Synapses;tau Proteins;Testing;Thalamic structure;Traumatic Brain Injury;Validation

PROJECT_TITLE: Thalamic microglia drive cognitive impairment after cortical injuries

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it presents a unified model on how the interplay of genetics, epigenetics, and environment drive oncogenesis in hematological malignancies. A fuller comprehension of this process is necessary for future development of diagnostics to predict and prevent blood cancers and provide insight into cancer pathology in other cells and tissues. Thus, this proposal is relevant to the part of the NIH’s mission to foster creative discoveries pertaining to the causes, diagnosis, prevention, and cure of human diseases and to improve human health.

PI_NAMEs: PANNUNZIO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Ablation;activation-induced cytidine deaminase;Affect;artemis;B lymphoid malignancy;B-Lymphocytes;Biological Assay;cancer cell;Cell Line;Cells;Chemicals;chemotherapy;Chromosomal translocation;Chromosomes;Clinic;clinically relevant;Comprehension;Creativeness;Data;Development;Diagnosis;diagnostic development;Diet;digital;Disease;disease diagnosis;DNA;DNA Double Strand Break;DNA lesion;DNA Repair;DNA sequencing;DNA Structure;Early Diagnosis;endonuclease;Engineering;Environment;Environmental Exposure;Environmental Risk Factor;Enzymes;Epigenetic Process;Event;Failure;Fostering;Foundations;Future;Generations;Genetic;Genetic Diseases;genome-wide;Genomic Instability;Goals;Health;Heavy-Chain Immunoglobulins;Hematologic Neoplasms;Hematopoietic Neoplasms;high risk population;Human;human disease;Human Genetics;IGH@ gene cluster;improved;Individual;individualized medicine;innovation;insertion/deletion mutation;insight;Kinetics;Knowledge;Laboratories;Lesion;Life Style;Link;Lymphoid Cell;lymphoid neoplasm;Malignant lymphoid neoplasm;Malignant Neoplasms;Maps;Measures;Mission;Modeling;Molecular;molecular sequence database;Monitor;mortality;mutant;Oncogenic;Pathologic;Pathologic Processes;Pathology;patient response;Patients;pharmacologic;Pharmacotherapy;Physiological Processes;Poison;prevent;Prevention;Process;prognostic value;Public Health;Relapse;repaired;Research;Risk;Role;Sampling;Secondary Cancer Prevention;Single-Stranded DNA;Source;Stress;Structure;System;Testing;Tissues;TOP2A gene;Topoisomerase;Translocation Breakpoint;treatment response;tumorigenesis;United States National Institutes of Health;V(D)J Recombination;Work

PROJECT_TITLE: Aberrant V(D)J recombination in B cells initiates lymphoid malignancy

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]