NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The proposed research and training will allow Dr. Alana Biggers to obtain critical research skills and study a mindfulness meditation program designed to improve sleep and reduce stress in African-American adults with diabetes. If effective, this program may reduce the risk of cardiovascular disease among African-Americans with type 2 diabetes who are at high risk of cardiovascular disease.

PI_NAMEs: BIGGERS, ALANA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;African American;African American population;American;Attention;attentional control;Behavior;behavioral health;Behavioral Research;biological adaptation to stress;Biological Markers;Blood Pressure;C-reactive protein;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;career;Caring;Chronic;Chronic Disease;Chronic stress;cohort;comparison control;Data;Data Analyses;Data Collection;design;Diabetes Mellitus;diabetes self-management;Disease;Educational Curriculum;emotion regulation;Evaluation;follow-up;glycemic control;Glycosylated Hemoglobin;Goals;Grant;group intervention;Health Disparities Research;health disparity;high risk;Home;Hyperactivity;Hypothalamic structure;improved;improvement on sleep;Inflammation;Inflammatory;Institution;Interleukin-6;Intervention;Intervention Studies;knowledge base;Life Style;Lipids;Longitudinal Studies;Mediating;Mentorship;Metabolic dysfunction;Methodology;Methods;mHealth;mindfulness;mindfulness meditation;Mindfulness Training;Minority Groups;mortality;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Participant;perceived stress;Persons;Physicians;Pilot Projects;Pituitary Gland;poor sleep;Population;primary outcome;programs;Psychological Stress;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Self Perception;skills;Sleep;Sleep Disorders;sleep health;sleep quality;Sleeplessness;Socioeconomic Status;Stress;stress management;stress reduction;stressor;Text Messaging;TNF gene;Training;Work

PROJECT_TITLE: My ESSENCE - Mindfulness to Reduce Stress, Improve SIeep, and Reduce Cardiovascular Risk in African-Americans with Type 2 Diabetes


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Post-zygotically acquired genetic variation that arises during brain development has been shown to lead to severe focal epilepsy. The F99 phase of this proposal investigates the role of somatic mutations in focal epilepsy and, in the K00 portion, proposes to use the zebrafish model system to further understand the effects of the disease-causing variants on the developing brain.

PI_NAMEs: BERGLIND, ANA ERICKA (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affect;anti-epileptic agents;Bar Codes;Biological Models;Blood;Brain;Brain region;brain tissue;career;cell type;Cells;Clinical;Communication;community involvement;Complementary DNA;Cortical Dysplasia;Cortical Malformation;Custom;Data;design;Detection;Development;Disease;disease-causing mutation;DNA sequencing;Doctor of Philosophy;drug discovery;Drug resistance;ds-DNA;Embryo;Environment;Epilepsy;Excision;exome;exome sequencing;Experimental Designs;Focal Seizure;Fostering;Foundations;Functional disorder;gene discovery;Genes;Genetic;genetic architecture;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genotype;Germ Lines;Germ-Line Mutation;Goals;graduate school;hemimegalencephaly;improved;in vivo Model;Individual;interest;Intractable Epilepsy;Lesion;Magnetic Resonance Imaging;Mentors;Mentorship;Modeling;Molecular Diagnosis;Mosaicism;neocortical;novel;novel sequencing technology;novel therapeutic intervention;Operative Surgical Procedures;Partial Epilepsies;Pathogenicity;Pathway interactions;Patients;Phase;Phenotype;Population;post-doctoral training;Postdoctoral Fellow;precision medicine;radiological imaging;Research;Research Personnel;Research Project Grants;Resected;Resources;Role;screening;Seizures;Shapes;skills;Somatic Mutation;System;targeted sequencing;Technical Expertise;Testing;Therapeutic;Tissues;Training;Translating;Variant;Work;Zebrafish

PROJECT_TITLE: Discovery and functional characterization of somatic variation in intractable focal epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cervical cancer is the most frequently detected cancer in women living with HIV and is highly preventable if precursor lesions are identified and treated before progression to invasive cancer; yet, it remains one of the most common causes of cancer-related death in women in low- and middle-income countries. The goal of this project is to accelerate the implementation of Screen, Triage, and Treat, an evidence-based cancer control intervention for women living with HIV, by leveraging existing HIV treatment and prevention infrastructure at Clínica de Familia in La Romana, Dominica Republic. Consequently, we aim to generate data that can inform effective and equitable implementation of evidence-based cancer control for persons living with HIV worldwide.

PI_NAMEs: BÁEZ, PAMELA ;SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Acceleration;Acetic Acids;Acquired Immunodeficiency Syndrome;Address;Adoption;aging population;Botswana;burden of illness;Cancer Control;Cancer Detection;Cancer Etiology;cancer invasiveness;care seeking;care systems;Caring;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;clinical decision support;Clinical effectiveness;co-infection;Collaborations;Communities;comorbidity;Country;Data;Death Rate;Disease;Disparity;Dominica;Dominican Republic;Educational Materials;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Ensure;Equity;evidence base;experience;extend lifespan;future implementation;Goals;Guidelines;health care delivery;Health Personnel;high risk;Histologic;HIV;HIV Seronegativity;Human Papillomavirus;hybrid type 2 trial;implementation design;implementation determinants;implementation evaluation;implementation science;implementation strategy;improved;Incidence;Income;India;Inequality;Inequity;Informatics;Infrastructure;Intervention;Kenya;Latin America;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;mHealth;multidisciplinary;Pain;Pathway interactions;Patient Education;Persons;premalignant;Prevention;Preventive screening;primary care clinic;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reproductive Health Services;Research;Research Personnel;response;Risk;Safety;scale up;screening;screening program;screening services;Secondary Prevention;sexual and reproductive health;South Africa;support tools;system-level barriers;Tanzania;Target Populations;Testing;treatment services;Triage;Universities;uptake;Visit;Visual;Woman;Women's mortality;World Health Organization

PROJECT_TITLE: Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana (iSTAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-M (M2)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Leveraging long-standing Hopkins-Uganda partnerships with substantive HIV, hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) research, clinical and laboratory infrastructure, our internationally recognized HIV and cancer implementation science leadership team will implement the Liver Cancer Comprehensive Control (LC3) package into key areas of the HIV care delivery system. We will address multiple levels of liver cancer control and broadly serve as a model for integrating complex cancer control intervention packages into existing HIV care delivery.

PI_NAMEs: BARAL, STEFAN DAVID;KIRK, GREGORY D (contact);OCAMA, PONSIANO

PROJECT_TERMS: Adoption;Adult;Africa;Africa South of the Sahara;Aging;antenatal care;anti-cancer research;Anti-viral Therapy;antiretroviral therapy;Area;Attention;Birth;cancer care;Cancer Control;Cancer Intervention;cancer therapy;care delivery;Caring;Chronic Hepatitis B;Clinic;Clinical;clinical infrastructure;Clinical Management;co-infection;Communicable Diseases;Communities;Complex;Consolidated Framework for Implementation Research;contextual factors;cost effectiveness;Country;Data;Detection;Diagnosis;Diagnostic;Diagnostic Services;Diagnostic tests;Dose;Early identification;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Elements;Epidemiology;evidence base;follow-up;Funding;Goals;Government;Hepatitis;Hepatitis B;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C;HIV;Hybrids;implementation barriers;implementation evaluation;implementation science;implementation strategy;Incidence;Income;Infrastructure;International;Intervention;Knowledge;Laboratories;Leadership;Link;Liver diseases;Maintenance;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Modification;Monitor;mortality;Newborn Infant;Patients;Persons;Phase;Population;Populations at Risk;Predisposition;Pregnant Women;Prevention;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;primary outcome;Primary Prevention;programs;Provider;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;Research Methodology;Research Personnel;routine care;Rural;rural area;scale up;screening;secondary outcome;Services;Site;Stage at Diagnosis;Staging;System;treatment services;Uganda;Universities;Vaccination;West Nile;Work

PROJECT_TITLE: Leveraging HIV care infrastructure for implementation of context-adapted liver cancer comprehensive control strategies in Uganda: The LC3 Study


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Caregiving Research;Childhood Obesity;Clinical Research;Diabetes;Disability Research;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE While survival in individuals with Down syndrome (DS) has improved greatly, multiple co-occurring conditions jeopardize quality of life and threaten life expectancy. Limited research examining either the natural history or the underpinnings of these comorbidities is available for informing screening practices and therapeutic interventions. This proposal will study the occurrence and emergence of multiple co-morbidities as well as ethical issues and social determinants of health affecting a diverse group of infants, youth, and young adults with DS.

PI_NAMEs: KELLY, ANDREA BRIDGET (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: ableism;Acceleration;Achievement;Adolescence;Adolescent;Adult;Affect;Age;Ally;Alzheimer's Disease;Area;arterial stiffness;Audiology;Behavior Therapy;biobank;Biological;Black race;Blood Pressure;Blood specimen;Body Composition;Bone Density;bone mass;brain magnetic resonance imaging;cardiometabolism;Cardiovascular system;Caregiver Burden;Caregivers;Caring;Catalogs;Central Sleep Apnea;Characteristics;Childhood;Childhood Leukemia;clinical care;clinical practice;Cognitive;cohort;Collaborations;Communities;comorbidity;Complement;Conductive hearing loss;Congenital Heart Defects;Country;Coupled;Data;Decision Making;Defect;demographics;Dermatologic;Desire for food;Development;Diagnosis;Disease;Disease Marker;Disparity;Down's Syndrome;Education;Electroencephalography;electronic health information;Electronic Health Record;Endocrine;Ensure;epidemiologic data;Ethical Issues;Ethics;Ethnic Origin;excessive weight gain;experience;Face;Family;gastrointestinal;Genome;Genomics;Geographic Locations;Glucose;Goals;gonad function;Growth;Health;health care availability;health disparity;heart defect;Hematologic Neoplasms;High Prevalence;Hispanic;Hyperthyroidism;Hypoventilation;Image;imaging study;improved;Income;Individual;infancy;Infant;Inflammation;Infrastructure;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intake;Intellectual functioning disability;Intervention;Intervention Studies;Intervention Trial;Interview;Investments;Left Ventricular Mass;Life;Life Expectancy;life span;Light;Link;Lipids;literacy;Longitudinal cohort;Longitudinal Studies;Measures;Medical;member;metabolome;metabolomics;multidisciplinary;multiple omics;Natural History;Neighborhoods;Neurocognitive;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;Observational Study;Obstructive Sleep Apnea;Orthopedics;Osteoporosis;Outcome;Overweight;Participant;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Physiologic Monitoring;poor health outcome;Population Heterogeneity;Predisposition;Premature Ovarian Failure;preservation;prevent;Procedures;prospective;Proteome;Proteomics;pubertal timing;Quality of life;Questionnaires;Race;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Personnel;resilience;Risk;Risk Factors;Role;sample collection;Satiation;screening;secondary analysis;sedentary;Sensorineural Hearing Loss;Sensory impairment;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;sleep quantity;social health determinants;Socioeconomic Status;socioeconomics;Specimen;structural ableism;survivorship;System;Therapeutic Intervention;Thyroid Function Tests;transcriptome;type I and type II diabetes;United States National Institutes of Health;Work;young adult;Youth

PROJECT_TITLE: Advancing the Lives & HeaLth of Youth and Young Adults with Down Syndrome (ALLY-DS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (55)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PI_NAMEs: CLARKE, THOMAS L (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Age related pathologies;Architecture;ATAC-seq;ataxia telangiectasia mutated protein;Award;Biochemical;Biochemistry;Biological Assay;Biological Models;BRCA1 gene;cancer risk;cDNA Expression;cDNA Library;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Structure;Complex;Coupled;Data;design;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Environment;Enzymes;Event;Excision;experimental study;Exposure to;Expression Library;Genes;Genetic;genome integrity;Genome Stability;Genomic Instability;Goals;helicase;high throughput screening;homologous recombination;Immunofluorescence Immunologic;Immunoprecipitation;in vivo;Innovative Therapy;Instruction;Ionizing radiation;Link;Maintenance;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediator;Mentors;Methodology;Modification;Molecular Biology;Mutagenesis;Neurodegenerative Disorders;novel;nuclease;Outcome;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phase;phosphoproteomics;Phosphotransferases;Post-Translational Protein Processing;Process;Prognosis;Protein Biochemistry;protein complex;protein protein interaction;Proteins;Publications;recruit;Regulation;repaired;Research;Resolution;response;Role;screening;Series;Site;Source;Techniques;Therapeutic Intervention;therapy resistant;Toxic Environmental Substances;treatment response;Ultraviolet Rays;Validation;Work

PROJECT_TITLE: Identifying chromatin factors essential for DNA repair using a novel high-throughput screening methodology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Women living with HIV (WLWH) have a very high likelihood of developing and dying from cervical cancer due to the challenges they face in accessing care and treatment in low- and middle-income countries (LMIC) such as Kenya in sub-Saharan Africa (SSA). Despite support from the President’s Emergency Plan for AIDS Relief (PEPFAR) and other donor agencies (Go Further) to screen WLWH at HIV clinics, the number of WLWH identified as having pre-cancerous cervical lesions and successfully receiving treatment remains so low as to have a nearly insignificant impact on cervical cancer morbidity and mortality in LMIC and SSA. In this implementation science study, we propose to work with patients, clinicians, facility managers, communities, and government partners at publicly funded HIV clinics in Kenya to adapt and test methods to effectively screen WLWH for cervical cancer using World Health Organization guidelines, and link screen positive women to treatment in a sustainable manner that not only improves HIV care, but successfully prevents cancer.

PI_NAMEs: ALI, MOHAMMED KUMAIL;CHUNG, MICHAEL HOONBAE (contact);MUGO, NELLY RWAMBA

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Address;Administrator;Adopted;Africa South of the Sahara;African;Attitude;Awareness;behavior change wheel;Behavioral;burden of illness;Cancer Etiology;care fragmentation;care seeking;Caring;Cervical;Cervical Cancer Screening;Cessation of life;Clinic;clinical care;Clinical Trials;Collaborations;Communities;cost;cost effectiveness;cost estimate;Country;Data;design;Diagnostic;Diagnostic tests;Early Diagnosis;economic impact;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Emergency Situation;Ensure;evidence base;Face;Female;follow-up;Fracture;Funding;Goals;Government;Guidelines;Health;Health Policy;Health Services Accessibility;high risk;HIV;HPV positive;Human;Human Papillomavirus;Human Resources;Hybrids;implementation barriers;implementation cost;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;Infrastructure;innovation;Institution;integrated care;Kenya;Knowledge;Lesion;Letters;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Meta-Analysis;Methods;mHealth;Mobile Health Application;Modeling;Morbidity - disease rate;mortality;Motivation;multidisciplinary;Outcome;patient-level barriers;Patients;Phase;premalignant;Preparation;prevent;Professional Organizations;Provider;provider-level barriers;Public Health Practice;Randomized;Readiness;Research;Research Technics;Resources;screening;Screening for cancer;self testing;Services;smartphone application;standard of care;Structure;System;system-level barriers;Tanzania;Testing;therapy design;tool;treatment strategy;Triage;uptake;Woman;Women's mortality;women's treatment;Work;World Health Organization

PROJECT_TITLE: ENHANcing CErvical cancer screening and treatment in women LIviNg with HIV in KenyA (ENHANCE LINKAge)


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Narrative In this application we are investigating the sex bias in EAE and therapeutic potential of a novel TNFR2 agonist and the mechanisms through which it works in significantly reducing neurological burden and supporting remyelination and regeneration in males and females.

PI_NAMEs: BETHEA, JOHN ROLAND (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Agonist;ATF6 gene;burden of illness;Cell Death;Cells;Central Nervous System;Coupled;Data;Disease;Disease Progression;Experimental Autoimmune Encephalomyelitis;Female;Genes;Genetic;Goals;Gonadal Steroid Hormones;hormonal signals;Immune response;improved;In Vitro;in vivo;Induced Neurons;Inflammation;Inflammatory Response;Knockout Mice;Ligation;Link;male;Mediating;Mediator;Motor;motor disorder;motor function improvement;motor impairment;motor recovery;Multiple Sclerosis;Mus;Myelin;Natural regeneration;Nerve Degeneration;Neuroimmune;Neuroimmune system;neuroinflammation;Neurologic;Neurons;neuropathology;novel;Oligodendroglia;painful neuropathy;Pathology;Pathway interactions;pharmacologic;Physiological;Predisposition;Process;programs;Protein Biosynthesis;Proteins;Publishing;Quality Control;Receptors, Tumor Necrosis Factor, Type II;Recovery of Function;Regenerative response;remyelination;repaired;response;Role;Series;sex;Sex Bias;Sex Chromosomes;Sex Differences;Signal Induction;Signal Transduction;Stress;Testing;Therapeutic;Therapeutic Effect;TNFRSF1B gene;transcriptome sequencing;Work;XBP1 gene

PROJECT_TITLE: TNFR2 sex differences and EAE

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative  The proposed study offers a multi-modal approach to identify necessary intervention components to improve HIV care outcomes by studying how durably virally suppressed Black sexual minority men overcome racism, intersectional stigma, and other barriers. Guided by Positive Deviance, we will study faciliators of viral suppression among Black sexual minority men living with HIV in Prince George’s County, MD and Shelby County, TN and use data visualization to identify actionable mechanisms for behavioral and/or multilevel intervention(s). Findings have crucial implications for designing high-impact interventions by elucidating existing strategies from successful community members that could be scaled for others.

PI_NAMEs: ANDERSON, JANEANE NICOLE;DANGERFIELD II, DEREK TRAMEL (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Behavior;Behavioral;Behavioral Mechanisms;Black race;care outcomes;Caring;Censuses;Characteristics;Clinic;Clinical;Communication difficulty;Communities;Community Health;Complex;Conscious;County;Data;data visualization;design;deviant;Diffuse;Dimensions;Discourse analysis;Disparity;effective intervention;Ensure;Epidemic;Ethnography;evidence base;experience;follow-up;Geography;Goals;Health;health goals;Health Planning;HIV;HIV Seropositivity;improved;Inequity;innovation;Intervention;Interview;Maps;member;men;multimodality;Neighborhoods;next generation;novel;novel strategies;Outcome;Outcome Study;Participant;participant interview;Pattern;Persons;Policies;provider communication;Public Health;racism;Research;Research Personnel;Resources;Route;sexual minority men;Site;social stigma;therapy design;Time;Transportation;Unconscious State;United States National Institutes of Health;Viral;Visit;Visualization;willingness;Work

PROJECT_TITLE: Identifying multilevel facilitators of care outcomes among Positive Deviants to design an intervention for Black sexual minority men living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Down Syndrome;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE. People with Down syndrome, the genetic condition caused by trisomy 21, display a unique clinical profile across the lifespan, including much elevated rates of diverse co-occurring conditions. Research efforts investigating the mechanisms by which trisomy 21 causes the hallmarks of Down syndrome, as well as the factors that modify these effects, will accelerate discoveries to improve health outcomes in this population. This project aims to develop a network of Down syndrome research sites in the USA and Latin America to increase the racial, ethnic, and socio-cultural diversity of investigations of the population with Down syndrome.

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact);FIDLER, DEBORAH J;RACHUBINSKI, ANGELA LYNN

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Adult;age acceleration;Aging;Alzheimer's Disease;Appearance;Argentina;autism spectrum disorder;Autoimmune Diseases;Award;biobank;Biological Process;biosignature;Brazil;Catalogs;Cells;Child;Chile;Clinic;Clinical;clinical risk;Clinical Trials;Cognitive;cognitive testing;cohort;Colombia;Colorado;Communities;Congenital Heart Defects;Country;Cultural Diversity;Data;data dictionary;data hub;Data Set;Development;Dimensions;Down's Syndrome;Enrollment;Ensure;epigenome;Epilepsy;ethnic diversity;Ethnic Origin;experience;extend lifespan;Functional disorder;Future;Generations;Genetic Diseases;Genome;genome analysis;Growth;Health;high risk;Human;Hypertension;Immune;Immune system;immunomodulatory therapies;improved;Individual;innovation;instrument;International;Investigation;Latin America;Latin American;Latino Population;leukemia;Life;life span;lifestyle factors;Malignant Neoplasms;Medical;member;metabolome;Metadata;Mexico;microbiome;mindfulness;Multiomic Data;multiple omics;Myeloproliferative disease;Natural History;neurodevelopment;Outcome;Participant;personalized approach;Persons;Pharmaceutical Preparations;Phenotype;Population;Population Study;Portuguese;Progeria;Program Development;Proteome;Protocols documentation;Race;racial diversity;Recommendation;Research;Research Activity;Research Personnel;Research Support;safety testing;Severities;Site;social culture;social health determinants;Solid;Spanish;Surveys;Training;transcriptome;Translating;Universities;virtual;working group

PROJECT_TITLE: Human Trisome Project - Latin America Network


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Coronary artery anomalies are a congenital disease severely affecting heart growth and function. This research project studies the developmental mechanisms that control the proper formation of the coronary arteries, with a goal to identify key regulatory factors that may be used for developing new therapies to combat this devastating disease.

PI_NAMEs: ZHOU, BIN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Affect;angiogenesis;Biological Assay;biomarker validation;Birth;Breeding;Cardiac;Cells;clinically significant;combat;Complement;Congenital Abnormality;Coronary;Coronary artery;Coronary Circulation;Coronary Vessel Anomalies;Coronary Vessels;Data;Data Analyses;data integration;Development;differential expression;Disease;effective intervention;Embryo;Embryonic Development;Endocardium;Endothelium;experimental study;Fluorescence-Activated Cell Sorting;gene network;Genes;Genetic;Genetic Markers;Goals;Growth;Heart;Histology;Hypoxia;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Individual;insight;Intervention;Knowledge;Label;Life;loss of function;malformation;Mesenchymal;Metabolic;Molecular;Mus;Myocardial;myocardial hypoxia;Myocardial Ischemia;Myocardium;Names;new therapeutic target;NOTCH1 gene;novel therapeutics;Pathogenesis;Pathway Analysis;Perinatal;perinatal period;Phenotype;Process;progenitor;Proliferating;Regulation;Reporter;Research Project Grants;Signal Transduction;single-cell RNA sequencing;Sinus;stem cell fate;stem cells;sudden cardiac death;Testing;TGFB2 gene;TGFBR3 gene;Transforming Growth Factor Beta 2;translational medicine;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;Ventricular;Visualization

PROJECT_TITLE: Molecular and Cellular Mechanisms in Coronary Artery Development and Anomalies

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The complexities of social interactions provide challenges for determining how neural computations of salient sensory signals lead to appropriate social behavioral output. In this proposal, I will use longitudinal behavioral monitoring, in vivo recordings, and circuit manipulations to describe how social behaviors such as maternal caregiving in mice and collective schooling behavior in teleosts are influenced by factors such as pup state or social environment during adolescence. These experiments will provide insight into how social information processing contributes to social behavior output and may lead to novel therapeutic targets for social behavioral deficits such as in autism spectrum disorder or parental neglect.

PI_NAMEs: CASLIN, ASHA  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Animals;appetite loss;autism spectrum disorder;Behavior;behavior change;Behavior monitoring;Behavioral;Behavioral Assay;Behavioral Genetics;Brain;Brain Diseases;Brain imaging;caregiving;Caring;Cells;Child;comparative;Complement;Complex;cost effectiveness;Cues;Data;density;designer receptors exclusively activated by designer drugs;Development;Disease;Doctor of Philosophy;Electrophysiology (science);Endotoxins;Evolution;Exhibits;experience;experimental study;Familiarity;Fatigue;Fishes;flexibility;Functional disorder;Genetic;Goals;Hypothalamic structure;Image;improved;improved outcome;in vivo;Individual;Infection;infection risk;Inflammation;information processing;insight;Lead;life span;Lipopolysaccharides;Machine Learning;magnocellular;Maternal Behavior;maternal caregiving;Measures;Methods;Modality;Monitor;Mothers;mouse development;multisensory;Mus;neglect;neural;neural circuit;Neurobiology;neuromechanism;Neuromodulator;Neurons;neurophysiology;Neurosciences;new therapeutic target;offspring;Optics;Output;Oxytocin;paraventricular nucleus;Parents;parvocellular;Phase;Population Dynamics;Postdoctoral Fellow;pre-doctoral;Predatory Behavior;preference;pup;Research;Research Project Grants;Resolution;response;Saline;Schools;Sensory;sensory integration;Shapes;Signal Transduction;Silicon;social;Social Adjustment;Social Behavior;social deficits;Social Development;social engagement;Social Environment;social factors;Social Hierarchy;Social Interaction;social interventions;social relationships;Stimulus;supraoptic nucleus;System;Techniques;Technology;teleost;Temperature;Testing;Time;tool;Transgenic Mice;virtual reality environment;Work;Zebrafish

PROJECT_TITLE: Neuro-Evolutionary Basis of Vertebrate Social Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Serious Mental Illness;Sleep Research;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Postpartum depression is common, undertreated, and has far reaching consequences for both mother and child; thus, novel, in-home treatments that remove barriers to care and target modifiable underpinnings are urgently needed. This administrative supplement will test the preliminary effects of wearable bright light therapy for postpartum depression on light sensitivity and determine associations among light sensitivity and postpartum depression symptoms, as well as the impact of changes in light sensitivity on improvements in postpartum depression symptoms. Findings from the study will inform treatment targets to reduce the major burden of postpartum depression, with long-term benefits for women and their offspring.

PI_NAMEs: SWANSON, LESLIE M (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Adherence;Administrative Supplement;Affect;Aftercare;anti-depressive agents;Arousal and Regulatory Systems;barrier to care;caregiving;Cessation of life;Child;Child Care;circadian;Circadian desynchrony;Circadian Rhythms;Clinic;Data Collection;depressive symptoms;Development;Disease remission;Enrollment;Ensure;Exposure to;Foundations;Functional impairment;Hamilton Rating Scale for Depression;Health Personnel;Health Services Accessibility;High Prevalence;Home;Hormonal;Impairment;improved;Intervention;Laboratories;Lactation;Light;Lighting;Measurement;Measures;Melatonin;Mental Depression;Mental disorders;Meta-Analysis;Mothers;Napping;National Institute of Mental Health;Newborn Infant;Nonpharmacologic Therapy;novel;Odds Ratio;offspring;Outcome;Parents;Participant;Pathogenesis;Pathway interactions;personalized medicine;Pharmacotherapy;Phase;Photophobia;Phototherapy;placebo group;Placebos;Population;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy Complications;Pupil;Randomized;Randomized, Controlled Trials;Recurrence;Research Domain Criteria;response;Retina;Role;satisfaction;Seasonal Affective Disorder;Seasons;Self Administration;Severities;side effect;Sleep;Sleep Wake Cycle;Suicide;System;Testing;Travel;United States;uptake;wearable device;Woman;Work

PROJECT_TITLE: A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Obesity

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Diabetes is a chronic illness affecting over 30 million people in the U.S and is defined by high glucose and disrupted regulation of pancreatic islet hormone secretion. Islet delta cells play a critical role to regulate glucose homeostasis and islet hormone secretion, but we know relatively litue about mechanisms that regulate delta cells. This proposal will reveal new signaling mechanisms governing islet function that potentially exert therapeutic benefits for diabetes.

PI_NAMEs: COX, RICHARD A (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acute;Affect;Alpha Cell;Animals;antagonist;Attention;Beta Cell;Biology;blood glucose regulation;Body Weight decreased;Cell membrane;Cell Physiology;Cell Proliferation;Cell secretion;cell type;Cells;Chronic Disease;Complex;Cues;D Cells;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Equilibrium;experimental study;Feedback;Functional disorder;Functional Imaging;Gene Deletion;gene therapy;Genes;Genetic;Genetic Transcription;Glucagon;Glucose;Goals;Health;Hormone secretion;Hormones;Human;Hyperglycemia;improved;In Vitro;inhibitor;Insulin;insulin secretion;insulin sensitivity;islet;Islet Cell;Islets of Langerhans;Leptin;leptin receptor;Maps;Measures;Mediating;Metabolic;Molecular;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nutrient;Obesity;Pancreatic delta Cell;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Persons;pharmacologic;Play;Positioning Attribute;prevent;Proliferating;receptor expression;Receptor Signaling;Regulation;Regulatory Pathway;response;restraint;Role;Satiation;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Somatostatin;Somatostatin Receptor;STAT3 gene;Structure of beta Cell of islet;Testing;Therapeutic;Time;tool

PROJECT_TITLE: Leptin regulation of delta cell function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Kidney Disease;Liver Disease;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project narrative  Many medical students have limited opportunities to participate in laboratory, clinical or translational research during their training. Consequently, the rate at which physicians can be recruited into research careers is low. The goal of the Medical Student Summer Research Program (MSSRP) and this Short-Term Medical Student Training Grant (T35 DK060444) is to provide medical students with short-term opportunities to participate in research projects that align with the NIDDK mission.

PI_NAMEs: BLACKARD, JASON T (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: absorption;Admission activity;African American;allergic response;Area;Asian;Basic Science;Biology;career;Chronic Kidney Failure;Clinical;Clinical Research;college;Data;demographics;Development;Diabetes Mellitus;disadvantaged background;Disease;Elements;Enterocytes;equity, diversity, and inclusion;Exclusion;experience;Faculty;Funding;Goals;Grant;gut microbiome;Gut Mucosa;Health;Hematological Disease;Hepatitis;Hispanic;Immune response;Immunology;Individual;Inflammatory;Inflammatory Bowel Diseases;Injury to Kidney;Institution;Intestines;Laboratory Research;liver development;Liver diseases;Medical;Medical center;medical schools;Medical Students;Medicine;Mentorship;Mission;Mucositis;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Nutritional;Obesity;Organoids;Outcome;Pediatric Hospitals;Pediatrics;Physicians;Positioning Attribute;Primary carcinoma of the liver cells;programs;Publications;recruit;Renal Carcinoma;Research;Research Personnel;Research Project Grants;Research Training;Structure;student training;Students;summer research;Training;Translational Research;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;Urologic Diseases;Virus Diseases;Woman

PROJECT_TITLE: Short-Term Institutional Research Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Memories are stored in neuronal circuits that are formed through the alteration of synaptic strength. However, the precise synaptic mechanisms that specifically contribute to memory formation are unclear. This proposal will provide insight into this process as well as describe a novel form of synaptic plasticity dependent on a virus-like signaling pathway.

PI_NAMEs: SULLIVAN, KAELAN REINALDO (contact)

PROJECT_TERMS: Ablation;Address;Affect;AMPA Receptors;Behavior;Behavioral Paradigm;Biochemical;Biological Assay;Capsid;career;Cell model;Cell Physiology;Cells;Data;Dendrites;Development;Electrophysiology (science);Evolution;experience;extracellular vesicles;Genes;Genetic;Genetic Materials;Goals;Growth;Image;Imaging Techniques;Immediate-Early Genes;In Vitro;in vivo;insight;intercellular communication;Kinetics;Knowledge;Label;Large-Scale Sequencing;Learning;live cell imaging;long term memory;Long-Term Depression;Long-Term Potentiation;Mediating;Memory;memory encoding;Memory impairment;Messenger RNA;Modernization;Modification;Molecular;mRNA delivery;mRNA Translation;Mus;Nervous System Disorder;neuronal circuitry;Neurons;Neurosciences;novel;Nucleic Acids;Pathway interactions;Phase;Positioning Attribute;Postdoctoral Fellow;Process;Progress Reports;Property;Proteins;Reporter;Research;Research Project Grants;Research Proposals;response;Retrotransposon;Retroviridae;Rodent;Role;Scientist;self assembly;Shapes;Signal Pathway;Signal Transduction;skills;Surface;Synapses;synaptic depression;Synaptic plasticity;System;Techniques;Testing;tool;trafficking;Translating;Translations;two-photon;uptake;vesicular release;Viral;Virus;Visualization;Work

PROJECT_TITLE: Investigating a novel form of intercellular synaptic plasticity


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Sexually Transmitted Infections

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project description  Sterols are critical for the structure of eukaryotic cells and serve as important signaling molecules. Some bacteria also engage with these lipids, but the molecular mechanisms of these engagements are not known. Inspired by our recent discovery of bacterial proteins that transport sterols, we seek to uncover the molecular determinants of sterol recognition and transport in other bacteria, including pathogens and the gut microbiome.

PI_NAMEs: DASSAMA, LAURA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: absorption;Affinity;Archaea;Bacteria;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Bioinformatics;Biological;Biological Assay;Biophysics;Borrelia burgdorferi;Cardiometabolic Disease;cell envelope;Cell Physiology;Cells;Chlamydia;Cholesterol;Coupled;Dyslipidemias;Ensure;Eukaryota;Eukaryotic Cell;Event;fabrication;Family;fluidity;Genomic approach;Genus Mycobacterium;gut microbes;gut microbiome;gut microbiota;Homologous Gene;Homologous Protein;hydrophilicity;Hydrophobicity;insight;Knowledge;Ligand Binding;Ligands;Lipid Binding;lipid metabolism;lipid transport;Lipids;Lipoproteins;Machine Learning;Mammalian Cell;Mediating;member;Membrane;Metabolism;Methylococcus capsulatus;Microfluidic Microchips;Microfluidics;microorganism interaction;Molecular;new therapeutic target;novel;Order Spirochaetales;Palmitic Acids;parent grant;pathogen;pathogenic bacteria;Pathogenicity;Periplasmic Binding Proteins;phosphonate;Polymers;Porosity;protein transport;Proteins;Proteome;Rapid screening;Regulation;Reporting;Research;Resistance;Rickettsia;Signal Transduction;Signaling Molecule;Site;Stearic Acids;Sterol Biosynthesis Pathway;Sterols;stress tolerance;structural genomics;Structure;Surface;Syphilis;Technology;Testing;Therapeutic Intervention;trafficking;Treponema pallidum;Treponema pallidum subspecies pallidum;virtual;Work

PROJECT_TITLE: Deciphering the molecular mechanisms of sterol lipid trafficking in bacteria

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Not applicable for this administrative supplement

PI_NAMEs: FLORES MILLENDER, EUGENIA ;KEEL, PAMELA K.;WONG, FRANK Y. (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TITLE: Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-Science Brigade


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Alzheimer's disease is a devastating, progressive neurodegenerative disease with few therapeutic options available to delay memory impairment. The post-translational modification, O-GlcNAcylation, is a promising therapeutic strategy since it can decrease accumulation of the pathological hallmarks, phosphorylated Tau tangles and amyloid-beta plaques. Using a transgenic rat model of Alzheimer’s disease, I will investigate whether increasing O-GlcNAcylation can protect against damage to the noradrenergic system and reduce hippocampal gliosis and synaptic function in early stage of the disease.

PI_NAMEs: GARCIA, MELISSA L (contact)

PROJECT_TERMS: abeta accumulation;Acute;AD transgenic mice;Adrenergic Receptor;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Astrocytes;Attention;Attenuated;Axon;axonal degeneration;Biological Markers;Biology;Brain;Brain region;Brain Stem;Calcium;career;Cell Nucleus;Cells;Clinical Treatment;Clinical Trials;Code;cognitive function;Compensation;Complement;confocal imaging;Delayed Memory;dentate gyrus;Disease;Disease Progression;Distal;Early Intervention;Electrophysiology (science);Enzyme-Linked Immunosorbent Assay;Enzymes;Exhibits;experience;extracellular;Functional disorder;gamma secretase;Genetic;Gliosis;Goals;Hippocampus;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;improved;inhibitor;insight;Link;locus ceruleus structure;Long-Term Potentiation;Mass Spectrum Analysis;Measures;Medial;Mediating;memory consolidation;Memory impairment;Microglia;Modeling;mouse model;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurological Models;Neurons;noradrenergic;novel strategies;Parahippocampal Gyrus;Pathogenicity;Pathologic;Pathology;Patients;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Perforant Pathway;pharmacologic;Phosphorylation;Post-Translational Protein Processing;Postdoctoral Fellow;preservation;prevent;prodromal Alzheimer's disease;Proteins;Proteomics;Publishing;Rat Transgene;Rattus;Reporting;Research;Research Personnel;Research Project Grants;Rodent Model;Role;Saline;Senile Plaques;Serine;Serine/Threonine Phosphorylation;Signal Transduction;Slice;Source;spatial memory;Synapses;synaptic function;System;tau aggregation;tau Proteins;tau-1;Technical Expertise;Testing;Therapeutic;Threonine;Time;transcriptomics;voltage;voltage clamp;Western Blotting

PROJECT_TITLE: Investigating the effects of increasing O-GlcNAcylation in Alzheimer's disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Climate-Related Exposures and Conditions;Skin Cancer

ORG_CITY: MADISON

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE:  The goal of this study is to determine the role and therapeutic significance of polo-like kinase 4 (PLK4), an important regulator of cell division, alone and in combination with other promising target-based agents, for the management of melanoma, which is one of the most dangerous form of skin cancers. Our study may ultimately lead to the development of novel therapeutic strategies for clinical management of melanoma.

PI_NAMEs: AHMAD, NIHAL  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adverse effects;Biogenesis;BRAF gene;Breslow Thickness;Cadherins;cancer cell;carcinogenesis;CDK4 gene;Cell Cycle Progression;Cell division;Cell Line;cell motility;Centrioles;Centrosome;Clinical;Clinical Management;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Cyclin D1;Dangerousness;Data;Development;Diagnostic;Disease Outcome;driver mutation;druggable target;epidemiologic data;epithelial to mesenchymal transition;Epithelium;experimental study;Failure;Fibronectins;Genetic Transcription;Genetically Engineered Mouse;genomic data;Genomic Instability;Goals;Human;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;inhibitor;Investigation;knock-down;Knock-out;Lesion;Link;liquid crystal polymer;LOX gene;Malignant - descriptor;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;melanocyte;Melanocytic nevus;Melanoma;Melanoma Cell;Melanoma Tumor;Mesenchymal;Metastatic Melanoma;Modality;Modeling;mortality;mouse model;Mutation;Neoplasm Metastasis;Neoplasms;New Drug Approvals;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;PET/CT scan;Phosphotransferases;PI3K/AKT;Play;PLK1 gene;Primary Neoplasm;prognostic;prognostic value;Protein-Serine-Threonine Kinases;Proteins;Publishing;Ras/Raf;Recurrence;Research;Resistance;Resistance development;response;Role;Sampling;Serine;Signal Transduction;Skin Cancer;small molecule;Snails;Specimen;Staging;System;Therapeutic;Time;Tissue Microarray;Transgenic Mice;tumor progression;Ultraviolet Rays;UV induced;Vimentin;X-Ray Computed Tomography;Xenograft procedure

PROJECT_TITLE: Functional and Therapeutic Significance of PLK4 in Melanoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  Post-concussive vestibular dysfunction is a significant source of persistent symptoms after concussion; results in multisensory processing deficits affecting balance, vestibular, and visual function; and leads to protracted recovery. Our proposed research aims to confirm our hypothesis that persistent post-concussive vestibular dysfunction is due to altered central vestibular processing, in particular with over-weighting of visual input into this system, resulting in subjective and objective vestibular dysfunction. The proposed study will fill a significant knowledge gap and advance our understanding of post-concussive vestibular dysfunction and visual- vestibular multisensory processing and dysfunction, as well as define endophenotypes of patients with post- concussion vestibular dysfunction based on clinical and neuroimaging metrics that predict response to vestibular rehabilitation therapy.

PI_NAMEs: ALLEN, JASON WILLIAM (contact);GORE, RUSSELL KAHN

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Affect;Affective;Age;Brain;Brain Concussion;brain magnetic resonance imaging;Brain region;Classification;Clinical;clinically relevant;Cluster Analysis;Cohort Studies;Compensation;Control Groups;Cues;Data;Development;Dizziness;endophenotype;Enrollment;Equilibrium;Etiology;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Image;improved;individualized medicine;Knowledge;Longitudinal Studies;Motion;motion sensitivity;multisensory;neuroimaging;novel;novel therapeutic intervention;novel therapeutics;oculomotor;Pathologic;Pathway interactions;Patients;Pattern;Peripheral;persistent symptom;Pilot Projects;Population;Population Heterogeneity;Post-Concussion Syndrome;predicting response;Prediction of Response to Therapy;predictive modeling;Prevalence;programs;Recording of previous events;Recovery;Rehabilitation therapy;Reporting;Research;research clinical testing;response;Rest;Sensory;Severities;sex;Source;Stimulus;Symptoms;System;Testing;treatment response;Vestibular dysfunction;Vestibular function;vestibular system;Vision;Visual;Visual Motion;visual-vestibular

PROJECT_TITLE: Altered Central Multisensory Processing in Post-concussion Vestibular Dysfunction

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Epilepsy;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE The development of adeno-associated virus (AAV)-mediated gene therapy has redesigned modern medicine by receiving multiple FDA approvals for diseases such as Leber Congenital Amaurosis, Duchenne’s Muscular Dystrophy, and Spinal Muscular Atrophy (SMA). Two white matter disorders, Alexander’s disease and Vanishing White Matter Disease (VWM), have no treatments currently available, and lead to the loss of myelination, neurological decline, seizures and premature death. Herein, we will utilize next generation techniques, such as scRNA-seq and spatial proteogenomics, to uncover disease mechanisms, while also aiming to apply novel therapeutic strategies including the combination of stress modulation, gene supplementation, and/or gene knockdown, in hopes to provide treatment for two diseases that have no cure.

PI_NAMEs: HERSTINE, JESSICA AUDREYANNA (contact)

PROJECT_TERMS: Affect;Alexander Disease;Animals;Area;Astrocytes;Automobile Driving;Autopsy;autosome;Behavior;Behavioral;Biochemical;biological adaptation to stress;biomarker identification;Body Weight;Brain;career;cell type;Cells;Cellular Stress;Central Nervous System;Cessation of life;Childhood;Clinical Trials;clinically relevant;Combined Modality Therapy;Complex;Data;Demyelinations;Dependovirus;design;design and construction;Development;Disease;Duchenne muscular dystrophy;efficacious treatment;efficacy evaluation;efficacy study;efficacy testing;EIF2B5 gene;Etiology;Eukaryotic Initiation Factors;Evaluation;Exhibits;experience;Fibroblasts;Functional disorder;gain of function;gain of function mutation;gene therapy;Genes;Genetic;Glial Fibrillary Acidic Protein;Goals;Histologic;Homeostasis;humane endpoint;In Vitro;in vivo evaluation;in vivo Model;Inherited;inhibitor;Injections;insight;Intellectual functioning disability;Intraperitoneal Injections;knock-down;Lead;Learning;Leber's amaurosis;leukodystrophy;Life;loss of function mutation;Magnetic Resonance Imaging;Mediating;Mendelian disorder;Modern Medicine;Molecular;Molecular Profiling;Motor;mouse model;multiple omics;Mus;Mutate;Mutation;myelination;Nature;Neurodegenerative Disorders;Neurologic;Neurosciences;next generation;novel therapeutic intervention;Pathogenicity;Pathology;Pathway interactions;Patients;Phase;Population;postnatal;preclinical efficacy;premature;prevent;proteogenomics;Regulation;Safety;Seizures;single-cell RNA sequencing;Spinal Muscular Atrophy;Stress;Supplementation;targeted treatment;Techniques;Telemetry;Testing;Therapeutic;therapeutic development;therapeutic target;Tissue-Specific Gene Expression;Training;transgene expression;Transgenic Organisms;Treatment Efficacy;vector;white matter;White Matter Disease

PROJECT_TITLE: Molecular profiling of seizures to provide comprehensive, durable, and targeted treatment for inherited white matter disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This project is a collaborative initiative between US researchers and Lao Ministry of Health officials to compare 2 smoking cessation implementation strategies for people with HIV who smoke in 8 antiretroviral therapy clinics in Laos. The proposed research is relevant to public health because it is ultimately expected to advance understanding of real-world impact of smoking cessation approaches in low- and middle-income settings. Findings from this project will contribute evidence that has the potential to shift national tobacco treatment strategies in Laos and in other low- and middle-income countries and subsequently reduce tobacco-induced cancer morbidity and mortality.

PI_NAMEs: BUI, THANH C. (contact);VIDRINE, DAMON J.;XANGSAYARATH, PHONEPADITH

PROJECT_TERMS: Abstinence;Adoption;antiretroviral therapy;Biochemical;Cambodian;Cancer Center;Cancer Survivor;care delivery;Caregivers;Cellular Phone;cigarette smoke;Clinic;Clinics and Hospitals;Cluster randomized trial;Collaborations;contextual factors;cost;cost effective;cost effectiveness;Country;Data;Developed Countries;digital platform;economic evaluation;effective intervention;Effectiveness;effectiveness/implementation study;Enrollment;Environment;Equity;evidence base;Female;Fogarty International Center;Funding;Future;Health;Health Sciences;Health Technology;Healthcare;HIV;HIV/AIDS;Hospitals;Hybrids;implementation fidelity;implementation outcomes;implementation science;implementation strategy;improved;Income;Influentials;Intervention;Laos;low and middle-income countries;male;Malignant Neoplasms;Measures;men;Methods;mHealth;mhealth interventions;modifiable risk;Morbidity - disease rate;mortality;National Cancer Institute;Oklahoma;participant enrollment;participant retention;patient engagement;patient population;Patients;Persons;Practical Robust Implementation and Sustainability Model;Prevalence;prevent;Printing;Procedures;programs;Province;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;relative cost;Research;Research Personnel;Resources;Risk Factors;self help;smartphone application;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;southeast Asian;Taxes;Text Messaging;Tobacco;tobacco control;tobacco products;Tobacco smoke;Tobacco use;Tobacco-Related Carcinoma;treatment program;treatment strategy;trial design;United States;Universities;Visit;Woman;Work;World Health Organization

PROJECT_TITLE: Implementing Sustainable mobile health Technology to Optimize smoking cessation Program for Lao people with HIV (I-STOP)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

PHR: PROJECT NARRATIVE Winship Cancer Institute of Emory University fully supports Manali Bhave, MD in her career goals to advance as a national leader in clinical trials for early therapeutics and the treatment of patients with breast cancer, and in her ongoing efforts to enhance the clinical trials program at Winship. The ECIA award will support protected time for Manali to focus on critical initiatives to build her leadership skills both within her institution and at a national level, create process improvements to expand access to and improve accrual to early phase therapeutic clinical trials, and further develop her investigator- initiated clinical trials at the national level. These activities expand upon her current undertakings and include new responsibilities to directly advance her career as an academic clinical researcher and leader at Winship Cancer Institute and within the NCI Trials Network.

PI_NAMEs: RAMALINGAM, SURESH S (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;American College of Radiology Imaging Network;Award;Breast;Breast Cancer Treatment;Breast Oncology;career;Career Mobility;Clinical;Clinical Investigator Award;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Unit;Data;Development;early phase clinical trial;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Faculty;fighting;Fostering;Funding Mechanisms;Goals;Growth;immunomodulatory strategy;Improve Access;improved;Infrastructure;Institution;Lead;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Oncologist;member;Monitor;new therapeutic target;participant enrollment;Patients;Phase;Phase I Clinical Trials;Physician Executives;Play;Principal Investigator;process improvement;programs;Protocols documentation;Research;Research Personnel;Role;Safety;skills;Southwest Oncology Group;Therapeutic;Therapeutic Clinical Trial;Time;Universities;working group

PROJECT_TITLE: Administrative Supplement: Early Career Cancer Clinical Investigator Award (ECIA)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Down syndrome (DS) is the most common genetic cause of intellectual disability, yet progress has been very limited in understanding how early brain development in DS relates to long-term functional outcomes. In this project, the Infant Brain Imaging Study, a team with over 15 years’ of experience in infant neuroimaging, will collect comprehensive, state-of-the-art brain and behavioral data in infants with DS at ages 6, 12, and 24 months, with collection at five clinical sites across the U.S. These data will allow identification and tracking of early brain differences in DS and their relationships to behavior, which can help guide intervention research aimed at improving developmental outcomes.

PI_NAMEs: HAZLETT, HEATHER CODY;MARRUS, NATASHA  (contact)

PROJECT_TERMS: Accounting;Address;Affect;Age;Age Months;Articulation;autism biomarker;autism diagnostic observation schedule;autism spectrum disorder;autism symptoms;autistic children;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;behavioral phenotyping;behavioral study;biomarker identification;Brain;brain behavior;Brain imaging;brain volume;Child;Clinical;clinical research site;Code;Cognition;Cognitive;cohort;Collection;Communities;comorbidity;Data;Data Collection;Development;developmental disease;Diagnosis;diagnostic tool;Dimensions;disorder risk;Down's Syndrome;Early Intervention;Early treatment;Electroencephalography;Environmental Risk Factor;Evaluation;Exhibits;experience;Family;Fragile X Syndrome;Functional Magnetic Resonance Imaging;functional outcomes;Future;Genetic;genetic analysis;Genotype;Goals;Heterogeneity;high dimensionality;human old age (65+);Image;imaging modality;imaging study;Impaired cognition;improved;Individual;individualized medicine;infancy;Infant;Intellectual functioning disability;Intervention;Intervention Studies;Knowledge;Language;life span;Longitudinal cohort;Longitudinal Studies;Magnetic Resonance Imaging;Measurable;Measures;Medical;Modality;Motor Skills;multidisciplinary;multimodal neuroimaging;natural language;Nature;neural;neural circuit;neurodevelopment;neuroimaging;novel;Outcome;Parents;Patient Recruitments;Pattern;pharmacologic;Phenotype;phenotypic data;Population;postnatal;predict clinical outcome;Prevalence;prospective;Protocols documentation;psychosocial;recruit;Reporting;repository;Research;response;Rest;Risk Assessment;Saliva;Sampling;Screening procedure;Severities;Site;Sleep;social attention;social communication;Socialization;sociodemographics;Source;Standardization;Structure;United States;Variant;visual tracking

PROJECT_TITLE: The Infant Down Syndrome Brain and Behavior Study


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The work proposed here is relevant to public health because elaborating the role of the leading autism risk gene SYNGAP1 in cilia formation will expand knowledge of autism pathobiology and is expected to give rise to new drugs and diagnostics for patients with variants in this gene, as well as for other autism -associated synaptic genes and potentially autism itself. Therefore, this work is relevant to the NIH’s mission to seek fundamental knowledge of living systems to reduce illness and disability. As a result, this project will provide rigorous training to an underrepresented graduate student in support of her independent career as a neuroscience principal investigator.

PI_NAMEs: KOSTYANOVSKAYA, ELINA  (contact)

PROJECT_TERMS: Address;Affect;Asthma;autism spectrum disorder;Binding;Bioinformatics;Biological Assay;Biological Models;Biology;Blindness;Brain;career;cell type;Cells;Chromosome Mapping;Cilia;Communication;comorbidity;Complement;congenital heart abnormality;Data Set;Defect;Development;disability;disabled;Disease;disorder risk;Educational process of instructing;Educational workshop;Environment;Epithelial Cells;excitatory neuron;experience;Faculty;Foundations;Funding;gene discovery;gene function;Genes;Genetic;Goals;graduate student;Grant;Heterozygote;Human;human induced pluripotent stem cells;human model;Hydrocephalus;Image Analysis;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Inosine Diphosphate;interest;Investments;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Lead;Leadership;Learning;lipidomics;Lipids;loss of function;member;Membrane;Mentors;Mentorship;Microscopy;Microtubules;Mission;model organism;Modeling;Molecular;Monitor;mutant;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;Neurosciences;Neurosciences Research;novel diagnostics;novel therapeutics;Organ;Organelles;Organism;Paper;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Phase;Phenotype;Phosphotransferases;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Principal Investigator;Process;Productivity;professor;programs;Proteins;Public Health;Publishing;Rattus;Research;Research Project Grants;Research Training;Resolution;risk variant;Rodent Model;Role;Scientist;Series;single-cell RNA sequencing;skills;success;symposium;Synapses;Synaptic plasticity;Syndrome;SYNGAP1;System;Technical Expertise;Techniques;Tertiary Protein Structure;tissue processing;Tissues;tool;Training;transcriptomics;Translating;United States National Institutes of Health;Variant;Visit;Work;Writing;Xenopus

PROJECT_TITLE: Beyond the Synapse: Convergence of Autism Risk Genes at the Cilium


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Brain states are widely distributed patterns of neural activity of specific physiological conditions and regulated by neuromodulatory tone. This proposal will develop a democratized longitudinal imaging protocol to acquire detailed information about brain states with and without adverse childhood experiences, before and after threat experience. Sophisticated computational strategies will be applied for development of neuromodulatory technology aimed at ameliorating residual effects on brain states in adults.

PI_NAMEs: USELMAN, TAYLOR W (contact)

PROJECT_TERMS: Acute;Address;Adult;adverse childhood events;Affect;Algorithms;Amygdaloid structure;Architecture;Atlases;automated segmentation;Brain;Brain Mapping;career;Clinical;Clinical Research;Computational algorithm;computational neuroscience;Computer Analysis;Computer software;Computing Methodologies;control theory;cost;Data;Data Set;Democracy;Development;digital;Disease;early life adversity;Effectiveness;Electrophysiology (science);Epidemiology;Equation;Ethics;Evolution;experience;Experimental Designs;experimental study;Exposure to;Fellowship;Focused Ultrasound;Fright;Future;Genetic;Goals;Hypothalamic structure;Image;improved;indexing;Individual;innovation;Intervention;Life;Literature;locus ceruleus structure;Magnetic Resonance Imaging;Manganese;Maps;Measurement;Measures;Mental disorders;Methods;Modeling;Molecular;Mus;neural;neural circuit;neural patterning;Neuroanatomy;neurobiological mechanism;neuroimaging;neuroregulation;noradrenergic;Outcome;Pathologic;Pathway Analysis;Pattern;Phase;Physiological;Physiology;Postdoctoral Fellow;pre-clinical;pre-doctoral;precision medicine;preclinical study;Prefrontal Cortex;Preparation;Process;Productivity;Protocols documentation;Psyche structure;Publishing;Reporting;Research;Research Personnel;Research Project Grants;Residual state;Resolution;response;Rest;Sampling;Science;serial imaging;skills;Statistical Methods;statistics;System;Talents;targeted treatment;Technology;Testing;Therapeutic Intervention;Time;tool;Training;Treatment Efficacy;Viral;Work

PROJECT_TITLE: Mapping and Modulating Brain States


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

PHR: Project Narrative This project aims to adapt and pilot test an existing evidence-based intervention (Project Accept, HPTN 043, U01MH066701) to reduce HIV-related stigma in pregnant and postpartum women in Ghana. Using ADAPT-ITT framework, we will modify the intervention for pregnant and postpartum women living with HIV using data from individual interviews and stakeholder consultation, and evaluate feasibility and acceptability in a pilot study designed to determine the potential efficacy of the intervention. Reducing stigma and depression and increasing antiretroviral treatment adherence in this population will help improve their quality of life and prevent mother-to-child transmission of HIV.

PI_NAMEs: OUNER, JERRY JOHN (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Adult;Adverse effects;Affect;Africa South of the Sahara;Age;age group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;anxiety symptoms;Attitude;behavior test;Behavior Therapy;Behavioral Model;care providers;Caring;Child;child bearing;clinical care;Collaborations;Communities;community advisory board;Consultations;Country;Data;depressive symptoms;design;Development;Dimensions;Discrimination;efficacious intervention;Epidemic;Evidence based intervention;Exclusion;experience;Family;Family member;Feedback;Female of child bearing age;follow-up;Fostering;Gender;General Population;Ghana;Goals;Health;health care service utilization;Health Personnel;Healthcare;high risk population;HIV;HIV Infections;HIV Seropositivity;Human immunodeficiency virus test;improved;improved outcome;Individual;Infant;infection rate;Intervention;Interview;male;Mandatory Testing;marginalization;Measures;men;Mental Depression;Mental Health;Modeling;Mother-to-child HIV transmission;Mothers;Nepal;Outcome;Participant;Patients;peer;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Population;Population Intervention;postnatal period;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Prejudice;Prenatal care;Prevalence;prevent;primary outcome;Process;programs;Provider;psychosocial;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Research;Research Design;Research Personnel;Resources;Risk;Sampling;secondary outcome;Services;Sexual Partners;social;social stigma;Social support;Social Values;Societies;South Africa;standard care;Stigmatization;Symptoms;Tanzania;Testing;Thailand;therapy adherence;therapy design;therapy development;Time;transmission process;treatment adherence;treatment as usual;Treatment Efficacy;United States;United States National Institutes of Health;Vertical Disease Transmission;Viral;Woman;Women's prevalence;young woman;Zimbabwe

PROJECT_TITLE: We Are Together (WAT):Development and testing of an intervention to reduce HIV-related stigma among pregnant and postpartum women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: ENSYSCE BIOSCIENCES, INC.

PHR: Narrative Prescription opioid abuse and addiction are major burdens to patients and society, resulting in significant costs, illnesses, and deaths from overdose. Ensysce Biosciences has created two complementary, novel technologies that control the release of known opioids and limit their use to oral administration. The abuse resistant features of Ensysce Biosciences’ TAAP™ and MPAR are built into the chemical modification of each prodrug. Our TAAP (Trypsin Activated Abuse Protection) prodrugs are “activated” by our own body to release clinically effective opioid drugs when swallowed and exposed to a ‘food digesting’ enzyme call trypsin found only in the gastrointestinal track. MPAR (multi-pill abuse resistance) involves regulation of the opioid delivery through the use of an added trypsin inhibitor in combination with the TAAP prodrugs, providing oral overdose protection to our opioid products. We have combined our TAAP oxycodone prodrug, PF614 with the trypsin inhibitor, nafamostat to produce PF614-MPAR. This combination with overdose protection has been evaluated in a two-part Phase 1 study which defined the 25 mg dosage strength combination. PF614-MPAR has shown to have a good safety profile and all the similar features of PF614 alone, with added overdose protection. The objective of this proposal is to advance the clinical development of PF614-MPAR through a multi-ascending dose study to move this highly novel opioid with overdose protection to a NDA and FDA approval as quickly as possible.

PI_NAMEs: KIRKPATRICK, LYNN  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: abuse liability;addiction;Address;Anticoagulants;Asian;attenuation;Back;Biological Availability;Biological Sciences;capsule;Cessation of life;Chemicals;Clinical;clinical development;Clinical Research;Clinical Trials;commercialization;Consumption;cost;Country;Data;Deglutition;design;Development;dosage;Dose;Drug Kinetics;Ensure;Enzymes;Exposure to;Fasting;Fentanyl;Food;Formulation;Future;Gastrointestinal tract structure;Goals;human study;Ingestion;Intravenous;Japan;Marketing;Modification;Molecular Weight;new technology;novel;novel therapeutics;Opiate Addiction;Opioid;opioid abuse;Opioid Analgesics;opioid overdose;Oral;Oral Administration;Overdose;overdose death;Oxycodone;Pain;pain relief;Patients;Persons;Pharmaceutical Preparations;Phase;phase 1 study;Physiological;pill;Plasma;preclinical study;prescription opioid;prescription opioid abuse;prevent;Prodrugs;Publishing;Regulation;Regulatory Pathway;Resistance;Safety;safety assessment;Small Intestines;Societies;synthetic opioid;System;Tablets;Technology;Therapeutic Equivalency;Time;Titrations;Trypsin;Trypsin Inhibitors;United States;Work;Writing

PROJECT_TITLE: PF614-MPAR: clinical development of opioid with oral overdose protection

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Significant cancer health disparities exist among Rio Grande Valley (RGV) Hispanic populations; however, biological, clinical, and other confounding factors contribute to these disparities are poorly understood. The proposed Rio Grande Valley Cancer Health Disparity Research Center (RGV-CHDRC) will develop a comprehensive biomedical research infrastructure and capacity building to reduce cancer and chronic diseases disparities in RGV region using multi-domain and multifactorial (basic, clinical, behavioral, social, biological) cutting-edge research, engaging relevant community partners/stake holders, and developing local health disparity research workforce. These activities will be crucial for developing successful intervention strategies to eliminate cancer and its associated chronic diseases health disparities in RGV populations, provide NIMHD access to this unique Hispanic population data and will allow NIMHD to have its footprint in the Rio Grande Valley.

PI_NAMEs: CHAUHAN, SUBHASH C. (contact);COBOS, EVERARDO

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Accountability;American;Area;Behavior Therapy;Behavioral;Behavioral Research;Biological;Biological Factors;Biomedical Research;burden of chronic illness;Cancer Burden;cancer diagnosis;cancer health disparity;Cancer Patient;chemotherapy;Chronic Disease;Clinical;Clinical Services;clinical translation;Collaborations;college;Communication;community engagement;community partners;Complement;Core Facility;culturally appropriate intervention;Data;Development;Diagnosis;disease disparity;Disparity;Early Diagnosis;Education;Educational Status;Ensure;Environment;ethnic minority population;Etiology;Faculty;Fellowship;flexibility;Fostering;Funding;Goals;graduate student;health determinants;Health Disparities Research;health disparity;Health Services Research;Healthcare;Hispanic;Hispanic Populations;Home;HPV screening;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Latino;Latino Population;Leadership;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Medical;Medicine;member;Mentors;Mexico;minority student;minority undergraduate;Mission;Modeling;Molecular;multidisciplinary;National Institute on Minority Health and Health Disparities;notch protein;patient population;Pilot Projects;Population;Postdoctoral Fellow;programs;Psychosocial Stress;Quality of life;racial minority population;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Services;social;Social Behavior;South Texas;Structure;successful intervention;Texas;therapy outcome;Training Programs;Translational Research;United States;Universities;University of Texas M D Anderson Cancer Center;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 KNL (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COBOS, EVERADO  (contact)

PROJECT_TERMS: Accountability;Address;Behavioral;Biological;Biomedical Research;cancer health disparity;Cardiovascular system;career;Chronic Disease;Clinical;Collaborations;Communication;Communities;community engagement;community partners;community research;Contracts;Core Facility;design;Development;Discipline;disease disparity;dissemination strategy;Education;Electronic Mail;Ensure;Environment;Evaluation;Face;Faculty;flexibility;Fostering;Goals;graduate student;Grant;Health;Health Disparities Research;health disparity;Health Services Research;Human Resources;implementation strategy;improved;Individual;Infrastructure;innovation;Institution;interest;Intervention;Kidney;Leadership;Logic;Malignant Neoplasms;Medical;meetings;member;Metabolic syndrome;Mexico;Minority;Minority Groups;Mission;Modeling;Monitor;National Institute on Minority Health and Health Disparities;novel;Outcome;Persons;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Procedures;Process;Productivity;programs;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Respiratory Disease;Social Behavior;Strategic Planning;Structure;successful intervention;symposium;Telephone;Texas;Time;Training;Training Programs;Translational Research;Travel;Universities;virtual;Work

PROJECT_TITLE: Rio Grande Valley Cancer Health Disparity Research Center


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: YALLAPU, MURALI MOHAN (contact)

PROJECT_TERMS: animal imaging;Applications Grants;Area;Artificial Intelligence;Basic Science;Behavioral;Behavioral Research;biobank;Bioinformatics;biomarker development;Biomechanics;Biomedical Research;Biometry;cancer health disparity;cellular imaging;Charge;Chronic Disease;Clinical;Clinical Research;Collaborations;community research;Consultations;cooking;Core Facility;cost;cost effective;cost effectiveness;Data;data acquisition;data management;Data Science;design;design and construction;Disease;drug development;Electronics;Engineering;Evaluation;Extramural Activities;Faculty;Feedback;fighting;flexibility;Flow Cytometry;food science;Funding;Generations;Genomics;Goals;Health;Health Disparities Research;Histopathology;HIV;Human;improved;Informatics;Infrastructure;innovation;instrumentation;interdisciplinary approach;Laboratories;Leadership;Maintenance;Malignant Neoplasms;Medical Device;Medical Research;member;Methods;Mission;molecular imaging;Monitor;multidisciplinary;Nanotechnology;National Institute on Minority Health and Health Disparities;novel;operation;Outcomes Research;Output;Pain management;Pharmacologic Substance;Pilot Projects;Policies;Probability;Procedures;Productivity;programs;Proteomics;Protocols documentation;Public Health Informatics;Publications;Radial;Records;Recovery;recruit;Regenerative Medicine;Research;Research Activity;research and development;Research Design;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;research study;Resource Allocation;Resources;Schedule;Science;Scientist;Services;Site;Statistical Methods;Strategic Planning;Structure;System;Techniques;theranostics;Therapeutic;Training;Underserved Population;user-friendly;Vector-transmitted infectious disease;Vision;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SALLOUM, IHSAN M (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Award;behavioral health;cancer health disparity;career;career development;Career Mobility;Collaborations;Communication;Communities;cultural competence;Dedications;Development;direct application;Discipline;Dissemination and Implementation;Environment;experience;Extramural Activities;Faculty;Feedback;Formulation;Fostering;Funding;Future;Generations;Goals;Grant;Health;Health Disparities Research;health disparity;Health Personnel;Health Services Accessibility;healthcare community;Hispanic;hospital care;Hospitals;improved;Information Dissemination;innovation;Investigator-Initiated Research;Journals;Knowledge;Leadership;Learning;Life Cycle Stages;Malignant Neoplasms;Measurable;Mentors;Mentorship;Methods;Mexico;Mission;Monitor;multidisciplinary;Outcome;Peer Review;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;Process;Program Development;programs;Publishing;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Role;Science;Scientist;Selection Criteria;social health determinants;socioeconomic disadvantage;success;Training;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Writing


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: TAPIA, BEATRIZ  (contact)

PROJECT_TERMS: Achievement;Area Health Education Centers;bilingualism;cancer health disparity;Caring;Clinical Research;Collaborations;Communication;Communities;community advisory board;community center;community engaged research;community engagement;Community Health;Community Health Education;Community Healthcare;Community Networks;community organizations;community partnership;cultural competence;Data;design;Devices;Diagnosis;Disease;Education;Education and Outreach;Ensure;evidence base;Evidence based practice;Financial Support;follow-up;Fostering;Foundations;Goals;Health;Health Disparities Research;health equity promotion;health goals;Health Priorities;Healthcare;Hispanic;Incentives;Industry;Institution;Knowledge;Latino;Leadership;low socioeconomic status;member;Methods;Outcome;outreach;Participant;patient navigation;Patients;Pilot Projects;Policies;Population;Population Heterogeneity;Prevention;programs;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resources;Rural Community;Rural Population;rural underserved;screening;Screening for cancer;Services;success;Testing;Translating;Translational Research;Trust;Uninsured;United States National Institutes of Health;Visual;Walking;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Genetics;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

PI_NAMEs: COBOS, EVERARDO  (contact)

PROJECT_TERMS: Affect;African American population;Age;Asian;Biological Assay;cancer cell;cancer diagnosis;Cancer Etiology;cancer health disparity;Cell Line;Cervical;Cervix Mucus;Cervix Uteri;Classification;Clinic;Clinical;clinically relevant;Collection;combat;Consensus;County;cytokine;Data;design;Disease;Drug resistance;Education;Elements;Enzyme-Linked Immunosorbent Assay;Event;Failure;Frequencies;Genes;Genetic;Genetic Polymorphism;genetic variant;Genomics;Genotype;Health Disparities Research;health disparity;Healthcare;Hispanic;Hispanic Populations;Hispanic Women;HPV analysis;HPV positive;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Human papillomavirus 16;Immune;Immune response;Immune Response Genes;Immunoglobulin A;Immunoglobulin G;Immunologic Factors;immunological status;Incidence;Infection;innovation;insight;intraepithelial;Investigation;Knowledge;Lesion;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Mexican;Modeling;mortality;mouse model;Mucous Membrane;Neoplasm Metastasis;neoplasm registry;novel strategies;Nucleotides;nutrition;Oncogenic;Organoids;Outcome Study;Pacific Islander;Pathology;Patients;Phylogenetic Analysis;Population;Population Heterogeneity;Poverty;preclinical trial;Prevalence;Prevention;Probability;Proteins;Publishing;Reproductive Health;reproductive tract;Resources;response;Risk;Role;Rural;rural counties;Sampling;Social Behavior;Squamous intraepithelial lesion;System;Technology;Testing;Texas;Therapeutic;Therapeutic Studies;therapy outcome;Time;Treatment Protocols;tumor progression;Underserved Population;Variant;White Women;Woman;Women's mortality


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Substance Misuse

PI_NAMEs: CHAUHAN, SUBHASH C. (contact)

PROJECT_TERMS: Adrenal Glands;Affect;Aflatoxins;Alcohol consumption;Arbitration;BAY 54-9085;Behavioral;Biochemical;Biological Specimen Banks;Cancer Etiology;cancer health disparity;Caucasians;Cell Line;Cells;Cessation of life;Chemoresistance;chemotherapy;Clinical;cohort;Communicable Diseases;cytokine;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;Disparity;disparity reduction;DNA Methylation;drinking behavior;Drug resistance;Endocrine;epigenome;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Etiology;Event;genetic variant;Genomics;Health Disparities Research;health disparity;Hepatitis;Hispanic;Hispanic Populations;histone modification;Hydrocortisone;Hypothalamic structure;In Vitro;Incidence;Infection;innovation;Interleukin-6;Latino;Leptin;Liver;Liver diseases;Malignant neoplasm of liver;Malignant Neoplasms;Measures;MEKs;Metabolic Diseases;Modeling;Molecular;Monoclonal Antibodies;mortality;Mucins;Mus;Neoplasm Metastasis;novel;Obesity;Oncogenic;Organoids;overexpression;Pathway interactions;patient derived xenograft model;patient population;patient prognosis;Patients;Pattern;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation;Pituitary Gland;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;programs;Proteins;Reagent;Recurrent disease;repository;Research;Resources;response;Risk Factors;Role;Sampling;Serum;Signal Transduction;Smoking;Smoking Behavior;social;Social Behavior;Stress;stressor;Time;Tissue Sample;Tissues;Treatment outcome;tumorigenic;Validation;Western Blotting;Xenograft procedure


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GEORGE, DEEPU  (contact)

PROJECT_TERMS: Acute;Address;Adoption;Anxiety;Appointment;behavioral health;Biological;Biological Markers;biopsychosocial;cancer care;cancer health disparity;Cancer Intervention;Cancer Patient;cancer recurrence;Cancer Survivor;Caring;Chronic;Clinic;Communities;County;cytokine;Disparity;disparity elimination;Dissemination and Implementation;Distress;Effectiveness;Equipment and supply inventories;Evaluation Studies;falls;flexibility;Focus Groups;Fright;functional improvement;Growth;Health;Health behavior;Health Disparities Research;Health Services;Health Services Accessibility;Health Services Research;Healthcare;Hispanic;Hispanic Populations;implementation fidelity;implementation framework;improved;Inflammatory;inflammatory marker;innovation;integrated care;Interleukin-6;Intervention;Latina;Latino Population;Maintenance;Malignant Neoplasms;Measures;Mental Depression;Mental Health;Modeling;Not Hispanic or Latino;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;peer;Physicians;Population;pragmatic trial;Primary Care;primary care clinic;primary care provider;Provider;psychologic;Psychological Impact;psychological outcomes;Psychological Stress;psychosocial;Questionnaires;research study;Risk;satisfaction;Screening for cancer;Self Management;social;Surveys;Survivors;survivorship;Texas;Time;TNF gene;Training;Treatment-Related Cancer;Variant;Visit


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: With the high prevalence of heart attack and stroke risk factors among Veterans, including age, it is not surprising that these diseases causing acute ischemic brain damage are extremely common in this population, with approximately 50,000 strokes per year. Stroke with heart attack are the third leading cause of death and the leading cause of disability in the US; placing a great demand on VA to provide disability and long-term care. By focusing on understanding injury mechanisms that leads to mitochondrial and ultimately cellular bioenergetic failure, the research in this proposal will promote the development of treatments with the ability to improve the long-term clinical outcome for stroke victims. Since cell death mechanisms triggered by ischemia are very similar to those causing brain damage due to traumatic brain injury; the new therapeutic approaches studied in this project will also have significant implications for treatment of traumatic brain injury (TBI) victims.

PI_NAMEs: KRISTIAN, TIBOR  (contact)

PROJECT_TERMS: Acetylation;Acute;Acute Brain Injuries;Address;Affect;Age;aging population;Animal Model;Animals;Astrocytes;Bioenergetics;Brain;brain cell;Brain Injuries;Brain region;Catabolism;Cause of Death;Cell Death;Cell Death Induction;Cell Survival;cell type;Cells;Chronic;Clinical;Clinical Trials;Complex;Consumption;Data;Deacetylase;Deacetylation;Death Rate;deprivation;disability;Disease;Dose;Drug Metabolic Detoxication;Enzymes;experimental study;Failure;Female;Fluorescence;Generations;Glucose;Glutamate-ammonia-ligase adenylyltransferase;Goals;Health;Heart Arrest;High Prevalence;Histologic;Impairment;improved;in vivo;Injury;insight;Ischemia;Ischemic Brain Injury;knockout animal;knockout gene;Link;Long-Term Care;male;Metabolic;Metabolism;military veteran;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Morphology;morphometry;mouse model;Myocardial Infarction;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurological outcome;Neurons;neuroprotection;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;novel;novel therapeutic intervention;nucleotide metabolism;overexpression;Oxygen;Pathologic;Pathway interactions;Pilot Projects;Play;Poly(ADP-ribose) Polymerases;Polymerase;Population;pre-clinical research;preservation;Process;Production;Prosencephalon;Protein Acetylation;Proteins;Reactive Oxygen Species;Regulation;Research;Respiration;Respiratory physiology;Ribose;Risk Factors;Role;Sirtuins;SOD2 gene;Stroke;stroke outcome;stroke risk;stroke victims;Superoxides;TBI treatment;Testing;Therapeutic;therapy development;Transgenic Animals;Transgenic Mice;translational approach;Traumatic Brain Injury;Veterans;Work

PROJECT_TITLE: The role of nicotinamide mononucleotide dependent mitochondrial reactive oxygen species generation in acute brain injury


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Children exposed to opioids antenatally can have behavioral problems, lower school achievement and changes seen on brain MRI scans compared to unexposed children. In this multicenter study, Case Western Reserve University is one of four centers enrolling a total of 200 exposed infants and 100 unexposed controls. We will follow this cohort to age 2 years to evaluate brain structure and function, examine development and behavior, and determine the relative effects of opioid exposure versus other environmental factors on outcomes. Contact PD/PI: Wilson-Costello, Deanne Project Narrative

PI_NAMEs: HIBBS, ANNA MARIA ;WILSON-COSTELLO, DEANNE E (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;Achievement;Age;Ancillary Study;antenatal;anxiety symptoms;Award;Behavior;Behavioral;Birth;Brain;brain magnetic resonance imaging;brain volume;Cephalic;Cerebrum;Certification;Child;Child Rearing;Childhood;clinical center;Clinical Research;clinical research site;cohort;Collaborations;Communication;connectome;Data;Data Coordinating Center;data repository;Deposition;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Enrollment;Environment;Environmental Risk Factor;experience;Exposure to;fetal opioid exposure;Fingerprint;follow-up;Funding;Goals;Grant;gray matter;Healthcare;high risk infant;Home environment;improved;Infant;Infrastructure;International;Laws;Life;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;Measures;Medical;Mental Health;Methodology;Mothers;MRI Scans;Multicenter Neonatal Research Network;Multicenter Studies;National Institute of Child Health and Human Development;Neonatal;neurodevelopment;neuroimaging;Newborn Infant;Opioid;opioid exposure;opioid use;Outcome;participant retention;Policies;Population;postnatal;Pregnancy;Problem behavior;Procedures;Productivity;programs;Protocols documentation;Psychotropic Drugs;Publications;Publishing;Questionnaires;Regulation;Research;Research Design;response;Rest;Sample Size;Schools;Site;social stigma;Standardization;Structure;success;Tissues;Training;Umbilical cord structure;United States National Institutes of Health;Universities;Visit;white matter injury

PROJECT_TITLE: CWRU Clinical Center - Outcomes of Babies with Opioid Exposure (OBOE) Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-N (55)]