ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Relevance  RNA polymerase (Pol) III-related leukodystrophy is a genetically-inherited neurodegenerative disease and the second most prevalent hypomyelinating leukodystrophy, but there is little understanding of disease pathogenesis. Using a mouse model of Pol III-related leukodystrophy, the first animal model to exhibit phenotypes similar to those seen in patients, the proposed research will significantly advance our knowledge of the molecular mechanisms of the disease while testing a potential therapeutic strategy that may benefit patients.

PI_NAMEs: WILLIS, IAN M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 7SL RNA;Adolescence;Affect;Affinity Chromatography;Animal Disease Models;Animal Model;Ataxia;Atrophic;autosome;base;Binding;biological adaptation to stress;Birth;Brain;brain magnetic resonance imaging;Brain region;Cell Physiology;Cells;Central Nervous System;Characteristics;Clinical;Clinical/Radiologic;Cognitive;Defect;Developmental Delay Disorders;Diagnosis;Disease;disease model;early childhood;Electron Microscopy;Endocrine;Enzymes;Eukaryota;Eukaryotic Cell;Exhibits;Fasting;Gene Modified;Genetic Models;Genetic Suppression;Genetic Transcription;genetic variant;Goals;Growth;healthspan;Hypodontia;Inherited;insight;Knock-in;Knock-out;Knowledge;leukodystrophy;life span;lipidome;Mitochondria;Molecular;Motor;mouse model;Mus;Mutant Strains Mice;Mutation;Myelin;myelination;Myopia;neurobehavioral;Neurodegenerative Disorders;Neurologic;Neurologic Deficit;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Onset of illness;Palliative Care;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Polymerase;Population;precursor cell;Property;protein biomarkers;Protein Biosynthesis;Protein Secretion;Proteome;Research;Ribosomal RNA;Ribosomes;RNA;RNA Polymerase III;RNA Processing;RNA Splicing;Role;Spinal Cord;Syndrome;System;Testing;Therapeutic;Time;Tissues;transcriptome;Transfer RNA;Translating;Translations;U6 small nuclear RNA;Untranslated RNA;Work

PROJECT_TITLE: Studies on RNA polymerase III-related leukodystrophy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: FAIRFAX

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: By using advanced statistical learning approaches and computing tools to leverage 3D or higher imaging  information directly, the proposed research can facilitate the identification of disease biomarkers and  improve the accuracy of diagnosis, prognosis, and treatment for Alzheimer’s disease and related  dementias. The proposed project has the potential to make an impact on public health by enhancing our  understanding of aging-related diseases.

PI_NAMEs: SONG, XIAO ;WANG, GUANNAN ;WANG, LILY  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;4D Imaging;Address;Adopted;aging biomarker;aging related disease;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Biological Markers;biomarker development;biomarker discovery;biomedical imaging;Brain;Brain imaging;Brain region;Clinical;computational platform;Computer software;Data;Diagnosis;diagnostic accuracy;Disease;disease diagnosis;disease prognosis;Effectiveness;Ensure;flexibility;Foundations;Four-dimensional;Friends;Functional Imaging;Genetic;Genetic Markers;genome wide association study;Goals;Health;Healthcare;Heterogeneity;high dimensionality;Image;image processing;imaging biomarker;imaging study;Imaging technology;improved;innovation;insight;Institution;interest;learning strategy;Magnetic Resonance Imaging;Measures;Medical;Medical Research;Methods;Modeling;Modernization;Multimodal Imaging;novel;Outcome;parallel computer;Performance;Phenotype;Positron-Emission Tomography;Prognosis;Public Health;rapid growth;Research;Research Personnel;Resolution;Sampling;scalable algorithms;Science;Shapes;Signal Transduction;sound;statistical learning;Statistical Methods;Statistical Models;structural imaging;Study Subject;Technology;Testing;Three-Dimensional Imaging;tool;two-dimensional;Uncertainty;Variant;X-Ray Computed Tomography

PROJECT_TITLE: SCH: Novel and Interpretable Statistical Learning for Brain Images in AD/ADRDs


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We propose BossDB, an open, accessible, cloud-based data archive for storage of multi-petabyte, high reso- lution, volumetric electron microscopy and X-ray microtomography datasets, as well as new connectomics and neuroimaging search, querying, and data annotation capabilities. As a current BRAIN Initiative data archive of record, BossDB leverages a proven architecture to provide petascale-capable storage, processing, sharing, and visualization of the massive and complex data generated by the connectomics community. BossDB will revo- lutionize how researchers share, annotate, and analyze data through a standardized, highly-available interface and ecosystem interconnected with community tools.

PI_NAMEs: WESTER, BROCK A. (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Algorithms;application programming interface;Architecture;Archives;Atlases;Brain;BRAIN initiative;Cell Nucleus;cell type;Cells;clinical development;cloud based;Collaborations;Collection;Communities;comparative;complex data;computerized data processing;connectome data;cost;cost effectiveness;Data;data access;data analysis pipeline;data archive;Data Collection;data complexity;Data Compression;data ecosystem;data format;data integration;data resource;Data Set;data standards;Data Storage and Retrieval;data tools;Development;Dimensions;distributed data;Ecosystem;Electron Microscopy;Engineering;Ensure;experimental study;FAIR principles;file format;flexibility;Future;Generations;Genomics;high resolution imaging;Hybrids;Image;image processing;imaging Segmentation;imaging system;improved;Ingestion;Investments;Manuals;Metadata;Methodology;Methods;microCT;migration;Mitochondria;Modality;Morphology;multimodal data;Nervous System;neuroimaging;Neurons;Neurosciences;Neurosciences Research;next generation;novel;open data;Performance;petabyte;Phase;Play;Process;programs;query optimization;query tools;R24;reconstruction;Research;research and development;Research Personnel;Resolution;Resources;Role;Running;Science;secondary analysis;Services;Skeleton;Standardization;Synapses;System;Technology;tool;usability;Visualization;Visualization software;web services

PROJECT_TITLE: Boss: A cloud-based data archive for electron microscopy and x-ray microtomography


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Back Pain;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Rehabilitation

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: The proposed research entails integrative solutions that span design, modeling, and control to gain a scientific understanding of human-robot interaction for multi-disc human spine joints (in contrast to well-studied robot interaction with single joints like ankle or knee). Optimal assistance of human joints is usually achieved with exoskeleton torques that are about 50% of biological human joint torques no matter how much robotic torque is delivered to humans. How the human spine will respond to exoskeleton

PI_NAMEs: SU, HAO  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Algorithms;Anatomy;Ankle;Area;Artificial Intelligence;Back;Biological;Biological feedback;Biomechanics;career;Caregivers;cost;cost effective;Data;design;Development;Disabled Persons;doctoral student;Education;Educational Curriculum;Elderly;Electrical Engineering;Engineering;Ensure;exoskeleton;exosuit;experimental study;fire fighter;Future;Healthcare;Hip region structure;Human;human-robot interaction;improved;Injury;interest;joint loading;Joints;Journals;Knee;Knowledge;Learning;Lifting;Low Back Pain;Lower Back Injury;Machine Learning;Mechanics;Methods;mobile sensor;Modeling;multidisciplinary;Muscle;Musculoskeletal;Nature;Persons;Posture;Prevention;Productivity;programs;Publishing;Rehabilitation device;Research;Research Training;response;Robot;Robotics;Safety;Science;Signal Transduction;simulation;Soldier;spine bone structure;student training;Students;success;symposium;time use;Torque;Uncertainty;undergraduate student;Vertebral column;wearable device;Work;Workplace

PROJECT_TITLE: SCH: Spine-Hip Exoskeletons with Learning-Based Optimal Control for Low Back Pain Alleviation


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Infectious Diseases;Lung;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Lower respiratory infection and lung cancer are leading causes of death worldwide, with the COVID-19 global pandemic being an example of high lethality from lung disease. Alveolar type II (AT2) cells are the lung’s facultative stem cells that under normal conditions remain quiescent and assist with gas exchange, but in the case of acute lung injury, can execute and halt proliferation as needed to help regenerate tissue, while also being at risk for misregulated proliferation leading to lung adenocarcinoma. How AT2 cells fluctuate in and out of quiescence is unclear, therefore the goal of this proposal is to investigate the regulatory mechanism behind AT2 cell reversible activation to be applied in treatment of lethal lung injuries and cancer.

PI_NAMEs: LYNCH, ANNE  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: 3-Dimensional;Acute Lung Injury;Address;Alveolar;Alveolar Cell Type I;alveolar epithelium;alveolar type II cell;Area;ATAC-seq;Benchmarking;Cause of Death;Cell Death;Cell Differentiation process;Cell Proliferation;Cells;Chemical Injury;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;combat;Complement;Complement Activation;conditional knockout;Country;COVID-19;COVID-19 pandemic;Data;Detection;Distal;Epigenetic Process;epigenetic regulation;epigenomics;epithelial injury;Epithelium;FOSB gene;Gases;genetic approach;Genetic Transcription;Genomic approach;Goals;Growth;Heterogeneity;imaging approach;In Situ;Infection;Inhalation;injured airway;Injury;injury and repair;injury burden;Intervention;Kinetics;Label;Light;Lobe;Lower Respiratory Tract Infection;Lung;Lung Adenocarcinoma;Lung Diseases;lung injury;lung regeneration;Malignant neoplasm of lung;Maps;Mediating;member;Microscopy;Modeling;Molecular;mouse model;multiple omics;Mus;Natural regeneration;Nature;novel;Nuclear;parainfluenza virus;pathogen;Persons;Phase;Pneumonectomy;Poison;Proliferating;Recovery;repaired;Respiratory Tract Infections;response to injury;Risk;Role;Sendai virus;single cell analysis;single cell ATAC-seq;spatiotemporal;stem cell biology;stem cell function;stem cell population;stem cells;STEM field;surfactant;Testing;Three-Dimensional Image;Time;tissue regeneration;tissue repair;Tissues;Toxin;training opportunity;Transcription Factor AP-1;Transcriptional Regulation;Viral;Virus Diseases;wound healing;XCL1 gene

PROJECT_TITLE: AP-1 as a transcriptional regulator of AT2 cell reversible activation during lung injury response


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Public Health Relevance Statement HIV self-testing would benefit both high-risk populations unaware of their infection and individuals aware of their infection and under treatment. This project seeks to develop and validate an easy-to-use quantitative HIV self- testing device to allow lay individuals to perform HIV viral load measurement. Increasing access to routine viral load testing can significantly improve the health outcomes of people living with HIV and help to prevent the onward transmission of HIV towards ending AIDS as a public health threat.

PI_NAMEs: GUAN, WEIHUA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Age;Ambulatory Care Facilities;Antibody Response;antiretroviral therapy;Attitude;Awareness;Benchmarking;Benefits and Risks;Biological Assay;Blood;Blood Glucose;Blood specimen;Comprehensive Health Care;cost effective;Data;Detection;Devices;Diagnostic tests;Drug resistance;Early Diagnosis;Electronics;empowerment;experience;Failure;Fingers;Guidelines;Health;high risk population;HIV;HIV Infections;HIV Seronegativity;HIV-1;HIV/AIDS;Home;home test;Hybrids;improved;Individual;Infection;innovation;isothermal amplification;Laboratories;Lateral;Learning;manufacture;Mechanics;Mediating;Medical center;Methods;Microfluidic Microchips;Microfluidics;Monitor;Morbidity - disease rate;mortality;Nucleic Acid Amplification Tests;operation;Optics;Outcome;Participant;Patients;Perception;Performance;performance tests;Persons;Phase;Plasma;Play;Population;Preparation;prevent;Privatization;Process;programs;prototype;Public Health;public health relevance;Rapid diagnostics;Recommendation;Recovery;recruit;Reporting;Research;research clinical testing;Reverse Transcription;RNA;Sampling;satisfaction;screening;self testing;Sensitivity and Specificity;sex;Side;software development;Specimen;Surveys;Testing;Training;transmission process;treatment adherence;Treatment Failure;Treatment outcome;United States;usability;Validation;viral detection;Viral load measurement;Viral Load result;viral rebound;viral RNA;Virus;Whole Blood

PROJECT_TITLE: Home Fingerprick Blood-Based HIV Self-Test For Quantitative Monitoring Of Viral Rebound


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Better methods are urgently needed to measure therapeutic response and detect early relapse, especially in acute myeloid leukemia (AML), where 50 percent of patients that have a complete response to initial treatment go on to relapse within 2 years. Current methods for measuring minimal residual disease in AML are not sensitive enough, do not apply to all patients, and do not fully capture the genetic heterogeneity of the disease. In this project, we propose that utilizing personalized genetic mutations associated with a patient’s leukemia will result in more sensitive, quantitative, and general measurements of minimal residual disease, allowing for better evaluation of treatment efficacy and earlier detection of relapse, ultimately improving patient outcome in AML.

PI_NAMEs: MOFFITT, ANDREA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: academic preparation;Acute Myelocytic Leukemia;Aftercare;Algorithmic Analysis;Benchmarking;Biological;Biology;Blood;Blood specimen;burden of illness;Cancer Biology;cancer genomics;Cancer Patient;cancer type;career development;cell free DNA;cell type;Cells;Clinical;Clinical Markers;Clinical Research;clinical translation;Communication;Computational algorithm;cost;Data;Detection of Minimal Residual Disease;Development;Development Plans;Diagnosis;Disease;disease heterogeneity;Disease remission;DNA;DNA Sequence Alteration;Doctor of Philosophy;Drug resistance;Early Diagnosis;Educational process of instructing;Environment;Evaluation;Evolution;experience;Fellowship;follow-up;Frequencies;Future;Gene Frequency;Genetic;Genetic Heterogeneity;Genetic study;genetic variant;Genome;genomic data;genomic profiles;genomic tools;Genomics;Goals;Health;Hematopoiesis;Heterogeneity;improved;In complete remission;Informatics;innovation;insight;Intervention;Intervention Studies;Knowledge;Laboratories;Lead;leukemia;Leukemic Cell;leukemic stem cell;liquid biopsy;Long-Term Survivors;Lymphoma;Malignant Neoplasms;Measurement;Measures;meetings;Mentors;Mentorship;Methods;Modeling;Molecular;Molecular Biology;Monitor;mutant;Mutation;Nature;Neoplasm Circulating Cells;Nucleic Acids;Occupations;Paper;Patient-Focused Outcomes;Patients;personalized genomics;Phenotype;Pilot Projects;Population;Postdoctoral Fellow;precision genetics;predict clinical outcome;Preleukemia;professor;prognostic value;Property;Relapse;Research;Research Personnel;Residual Neoplasm;Residual state;Sampling;Sensitivity and Specificity;single cell analysis;single cell technology;skills;Somatic Mutation;success;symposium;Techniques;tenure track;Testing;Time;Training;transcriptomics;translational genomics;translational study;Treatment Efficacy;treatment response;Universities;Variant;Visit;whole genome;Work

PROJECT_TITLE: Measuring treatment response and residual disease in leukemia with personalized, sensitive, and quantitative genomic methods

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Entrepreneurship has emerged as a potent economic force and can be an avenue to increase the number of research innovations. However, gender and underrepresented minority (URM) gaps in entrepreneurship have been documented, and only 11.8% of inventors in the US are women. We propose an entrepreneurship educational program for women, including URM women with a unique approach that combines mentoring with coaching, as coaching has been shown to be four times more effective than training or mentoring alone.

PI_NAMEs: FEGHALI-BOSTWICK, CAROL A. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Advisory Committees;African American population;Behavioral;bench to bedside;Biomedical Research;Capital;career;Career Mobility;Climate;Communication;Communities;Data;Disparity;Economics;Education;education planning;education research;Ensure;Entrepreneurship;Evaluation;experience;Faculty;Funding;Gender;gender minority;Goals;Grant;holistic approach;innovation;Institution;Knowledge;Leadership;Learning;Life;male;Manuals;Measures;Medical;Mentors;Mentorship;Methods;Minority Women;next generation;Outcome;Participant;Perception;Population Heterogeneity;Program Evaluation;programs;Questionnaires;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Personnel;Resources;Role;role model;satisfaction;Scientist;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;South Carolina;success;Training;Underrepresented Minority;United States;Universities;Vision;Woman;women faculty;Work

PROJECT_TITLE: STEM-Coaching and Resources for Entrepreneurial Women (CREW)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: SAN FRANCISCO

ORG_NAME: CALIFORNIA PACIFIC MED CTR RES INSTITUTE

ORG_STATE: CA

PHR: Chronic hepatitis B virus infection (CHB) afflicts up to 2.2 million Americans, and up to 350 million people globally, causing early death in about 1 million people annually. In the “BeNEG-DO” grant we are studying an intervention aimed at safely stimulating immune-mediated clinical cures in patients with CHB by timed stoppage of standard- of-care medications, which rarely achieve cures. Initial data demonstrates that the intervention can work, but with some safety concerns. Continuation of the study will help identify patients likely to benefit from the intervention and those at risk.

PI_NAMEs: BARON, JODY L;COOPER, STEWART  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Aftercare;American;analog;Anti-viral Therapy;Antigen Presentation;arm;Asian population;Biochemical;Blood;Blood specimen;cell type;Cells;Cessation of life;Chronic Hepatitis B;Circular DNA;Cirrhosis;Clinical;Clinical Data;Clinical Treatment;Data;Diagnostic;DNA Viruses;e Antigens;Enrollment;falls;Funding;Gene Expression Profile;Genes;Genetic;Genomics;Grant;Greek;Healthcare;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B Virus;human data;Immune response;Immunity;Immunologic Stimulation;Immunologics;Intervention;Intervention Studies;liver biopsy;Liver diseases;Liver Failure;Mediating;Molecular;Monitor;mouse model;multi-ethnic;Outcome;outcome prediction;Participant;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Population;Primary carcinoma of the liver cells;Prospective Studies;Proteins;Proteomics;Request for Applications;Risk;Safety;San Francisco;Seminal;Serology;Shapes;standard of care;Surface Antigens;T cell response;Testing;Therapeutic;Tissues;Treatment outcome;Universities;Viral;Viral Proteins;Viral reservoir;Virus Replication;Withdrawal;Work

PROJECT_TITLE: Clinical & Immunological Study of Treatment Withdrawal in E-Ag Negative Hepatitis B

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: We aim to leverage the unique advantages of MrOS in the next phase of this project in order to characterize the circumstances of fracture in the oldest old; improve fracture prediction using CT-FEA; and identify determinants of change in peripheral bone microarchitecture. To do this, we will continue follow-up of the MrOS cohort and repeat skeletal health assessments (HR-pQCT) in a subset of surviving participants.

PI_NAMEs: BOUXSEIN, MARY L;CAWTHON, PEGGY MANNEN (contact);ORWOLL, ERIC S.

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Address;Age;Aged, 80 and over;Aging;bone;Bone Density;bone imaging;bone strength;Bone structure;Cessation of life;Clinical;clinical phenotype;clinical research site;cohort;Collection;Communication;cost;Data;Data Coordinating Center;design;Dual-Energy X-Ray Absorptiometry;Enrollment;falls;follow-up;Fracture;fracture risk;Funding;Future;Goals;health assessment;Hip Fractures;Hip region structure;human old age (65+);human very old age (85+);improved;Infrastructure;Knowledge;late life;Life;Measurement;Measures;men;Morbidity - disease rate;mortality;Musculoskeletal;novel;older men;osteoporosis with pathological fracture;Participant;Peripheral;Phase;Phenotype;Prospective Studies;Publications;Research Personnel;Resources;Risk Factors;Scanning;Scientific Advances and Accomplishments;scientific organization;skeletal;Source;Structure;Vertebral column;X-Ray Computed Tomography

PROJECT_TITLE: Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

PI_NAMEs: LEECH, KRISTAN A. (contact)

PROJECT_TERMS: Acceleration;Achievement;Adult;Affect;Aging;aging brain;Bilateral;biomechanical test;Brain;Brain imaging;career;Cerebellum;chronic stroke;Clinical;Cognition;Cognitive;Cognitive deficits;Cues;Dementia;Demographic Factors;Development;disability;effective intervention;effective therapy;Excision;Exhibits;Experimental Designs;Feedback;Foundations;Functional disorder;Gait;Gait abnormality;gait rehabilitation;Goals;human old age (65+);Imaging Techniques;Impaired cognition;Impairment;improved;Individual;insight;inter-individual variation;Intervention;K-Series Research Career Programs;Knowledge;Learning;Leeches;Length;Lesion;Location;Long term disability;Mediating;Motor;motor behavior;motor deficit;motor impairment;motor learning;Movement;neural;Neuroanatomy;neuroimaging;neuromechanism;Neuropsychology;older adult;Outcome;Participant;Patients;Pattern;Performance;Persons;post stroke;post stroke cognitive impairment;predictive modeling;Prefrontal Cortex;Procedures;Process;programs;Rehabilitation therapy;Reporting;Research;Research Personnel;Resources;response;Role;Severities;skills;Speed;statistics;Stroke;Structure;System;Testing;Thick;Training;treadmill;United States;verbal;Visual;visual feedback;Walking;Work

PROJECT_TITLE: Evaluating cognitive impairment as a moderator of locomotor learning in older adults post-stroke

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Healthcare costs for falls have reached 55 billion dollars annually in the US with falls in older adults impacting nearly every family, in every sector, of every community. Leveraging 911 fall calls as activation events could transform our ability to identify high risk individuals and significantly impact fall prevention strategies. At the completion of this study, a scalable EMS fall prediction tool will be developed to elucidate the impact that frailty, cognitive impairment and the home environment have on emergency fall events in order to activate and transform effective fall prevention solutions in the homes of vulnerable older patients.

PI_NAMEs: QUATMAN, CARMEN  (contact)

PROJECT_TERMS: 911 call;Address;Adoption;Caring;Cessation of life;Clinics and Hospitals;Cognition;Cognitive;Communities;community based participatory research;cost;Data;Early identification;Emergency medical service;Emergency Situation;Engineering;Environment;Evaluation;Event;experience;Fall prevention;fall risk;falls;Family;Focus Groups;follow-up;frailty;Future;Goals;Health Care Costs;Health Personnel;high risk;high risk population;Home;Home environment;Home visitation;Hospitals;Impaired cognition;implementation strategy;implementation trial;improved;Individual;Injury;innovation;Intake;Interview;Lifting;Machine Learning;machine learning algorithm;machine learning model;Maintenance;Medical;Methods;Nature;older adult;older patient;Outcome;Paramedical Personnel;patient stratification;Patients;Phenotype;Predictive Analytics;predictive modeling;predictive tools;Prevention;Prevention strategy;prognostic value;Protocols documentation;Provider;Public Health;Recurrence;Resources;Risk;Risk Factors;risk mitigation;risk stratification;Science;success;System;Time;United States;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Transformative Solutions for Reducing Frequent 911 Fall Calls in the Homes of Patients with Cognitive Impairments


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Through renewal of this K12 Career Development Program, we will continue to combine excellence in research mentoring, didactic education, and formal career development guidance to bring outstanding clinician scientists to careers in academic ophthalmology and vision research.

PI_NAMEs: WEINREB, ROBERT N (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Appointment;Area;Artificial Intelligence;Award;Basic Science;Biomedical Engineering;career;career development;Childhood;Clinical;Clinical Sciences;clinically relevant;Department chair;Education;Educational Curriculum;Ethics;Eye;Fellowship;Funding;Genomics;Glaucoma;Goals;Grant;human subject;Individual;Informatics;Institution;K-Series Research Career Programs;Lead;Leadership;Mentored Clinical Scientist Development Program;Mentors;Minority;next generation;Ophthalmology;Preparation;programs;Proteomics;recruit;Research;Residencies;responsible research conduct;Retina;Scientist;skills;statistics;stem cell biology;Structure;Training;United States National Institutes of Health;vision science;visual neuroscience;Woman;Writing

PROJECT_TITLE: Ophthalmology and Visual Sciences Career Development K12 Program


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Services;Hematology;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Prevention;Rare Diseases;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Telehealth;Transplantation

ORG_CITY: Millbrae

ORG_NAME: CARE.COACH CORPORATION

PHR: Narrative  Delirium, a major cause of falls, can occur in as many as 50% of cancer patients undergoing stem cell transplant,  resulting in up to 14 times greater chance of dying. Delirium risk can be mitigated and many other outcomes of  stem cell transplants can be improved through behavioral interventions delivered at the bedside through  conversation, imagery, and audio. care.coach™ is developing a technology-enabled cancer care platform that  provides 24x7 proactive bedside support for patients undergoing stem cell transplants, to mitigate delirium and  falls while improving recovery through better adherence to diet, exercise, and other best practices, in a scalable,  cost-effective manner.

PI_NAMEs: WANG, VICTOR  (contact)

PROGRAM_OFFICER_NAME: WEBER, PATRICIA A

PROJECT_TERMS: Address;Adherence;Adult;Advocate;African American;Age;Anger;Anxiety;anxiety management;anxiety reduction;Area;Behavior Therapy;behavioral health intervention;California;cancer care;Cancer Control;Cancer Patient;Canis familiaris;care coordination;Caring;Categories;Client satisfaction;Clinical;Clinical Protocols;Clinical Research;cohort;Collaborations;Communication;Communities;comparison group;Computer software;Control Groups;cost;cost effective;Delirium;depressed patient;depressive symptoms;design;Devices;Diet;digital;digital health;Disease Management;Distress;Elderly;Emotional;Event;evidence base;Exercise;experience;Expert Systems;Fall prevention;fall risk;falls;Feeds;Felis catus;Female;Goals;Health;health information technology;health plan;Hematology;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Hospitals;Human;Hydration status;Image;Imagery;Immune system;improved;Incentives;Incidence;Inpatients;Intervention;Interview;Jamaica;Language;Length of Stay;leukemia;Life;Loneliness;Lymphoma;Malignant Neoplasms;Measures;Medical;Medical center;Medical Oncology;Mental Depression;mHealth;mild cognitive impairment;Monitor;monocyte;mortality;mortality risk;multi-component intervention;Multiple Myeloma;National Cancer Institute;neutrophil;Nosocomial Infections;Nursing Students;Odds Ratio;older adult;Oncology;Operative Surgical Procedures;Outcome;Pain management;Paper;Patients;Pattern;Peer Review;Personal Satisfaction;Pharmaceutical Preparations;phrases;Physical Exercise;Physician Executives;Platelet Count measurement;Population;post-transplant;prevent;programs;Protocols documentation;Provider;Psychometrics;Psychosocial Assessment and Care;Publishing;Quality Control;Quality of life;Randomized;Recovery;Reporting;Research;Research Design;Review Literature;Risk;Risk Factors;Safety;San Francisco;satisfaction;Schedule;Self Management;side effect;Sleep;Sleeplessness;Small Business Innovation Research Grant;social;Social Interaction;Social support;Socialization;Spanish;speech synthesis;Spirometry;Stem cell transplant;Stress;Surveys;Survival Rate;Symptoms;Syndrome;Tablet Computer;Technology;Text;therapy development;Training;Transplant Recipients;Transplantation;Universities;usability;Validation;Visit;Visual;Voice;Washington;Work

PROJECT_TITLE: A Bedside Relational Agent to Improve Hematopoietic Cell Transplantation Outcomes in Cancer Patients


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Loss-of-function mutations in the DYRK1A gene have been tightly linked to neurodevelopmental disorders like autism spectrum disorders and intellectual disability. The research described in this proposal aims to uncover specific mechanisms by which DYRK1A influences the function of immature neural stem and progenitor cells in the developing brain and their commitment to specific neural identities. The results of our studies will identify potential therapeutic entry points for neurodevelopmental disorders by defining intracellular signaling pathways regulated by DYRK1A that can be modulated to restore normal brain function.

PI_NAMEs: PANAGIOTAKOS, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adoption;Affect;Astrocytes;autism spectrum disorder;Automobile Driving;Binding;Brain;Calcineurin;Calcium;Calcium Channel;Calcium Signaling;cell behavior;Cell Differentiation process;Cell Maintenance;cell type;Cells;Cerebral cortex;Cleavage Under Targets and Release Using Nuclease;Cues;Data;Development;developmental disease;Disease;DNA Binding;dosage;Dose;Down's Syndrome;Electroporation;Embryo;Equilibrium;Etiology;Event;excitatory neuron;extracellular;Foundations;Functional disorder;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Goals;Human;Human Genetics;Impairment;in utero;in vivo;insight;Intellectual functioning disability;Knowledge;L-type calcium channel alpha(1C);Link;loss of function;loss of function mutation;member;Mental disorders;Microcephaly;Molecular;Morphology;Mouse Strains;Mus;Mutate;Mutation;nerve stem cell;nervous system development;neural;Neurodevelopmental Disorder;Neuroglia;neuron apoptosis;neuron loss;Neuronal Differentiation;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurosciences;NFAT Pathway;novel;nuclear factors of activated T-cells;Patients;Phenocopy;Phenotype;Phosphotransferases;Play;postnatal;Production;programs;Proliferating;Publishing;Radial;Regulation;Reproducibility;Research;Role;Series;Signal Pathway;Signal Transduction;Specificity;STAT3 gene;stem;stem cells;Syndrome;Testing;Therapeutic;Thinness;Timothy syndrome;tool;transcription factor;Transgenic Organisms

PROJECT_TITLE: Cell type signaling specificity of the neurodevelopmental disease-associated DYRK1A kinase


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging;Chronic Pain;Pain Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative  Chronic pain represents a major public health problem disproportionately impacting older adults and an improved understanding of the neurobiological and psychosocial mechanisms underlying age-related changes in pain is critical to inform interventions aimed at reducing pain in the elderly. At present, there is a deficit of scientists trained to conduct clinical and translational research investigating pain and aging. In order to address this gap, we propose to continue our Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) postdoctoral training program with the long-term goal of creating the next generation of pain and aging scientists who will move the field forward through cutting edge research designed to elucidate and ameliorate adverse age-related changes in the experience of pain.

PI_NAMEs: FILLINGIM, ROGER B (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TITLE: the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Correct synapse formation is essential for brain development and defects in that process underlie a host of neurodevelopmental defects and loss of synapses is an early hallmark of neurodegenerative disorders such as Alzheimer's. This proposal seeks to understand the role of kinetochore proteins in the formation of synaptic terminals, dendrites, and dendritic spines. These proteins have never previously been implicated in any process other than cell division and the research, therefore, has the potential to expand our understanding of what shapes neuronal connections.

PI_NAMEs: SCHWARZ, THOMAS L. (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Alzheimer's Disease;Axon;Axonal Transport;Binding;Binding Sites;Brain;Cell division;Cell Nucleus;Cells;Centromere;Chromosome abnormality;Chromosome Segregation;Chromosomes;Competence;Complement;Complex;Cytoskeleton;daughter cell;Defect;Dendrites;Dendritic Spines;density;Development;Drosophila genus;Electron Microscopy;Electrophysiology (science);Embryo;Embryonic Development;fly;Genetic;Growth;Growth Cones;Hippocampus;Kinetochores;knock-down;Knowledge;Learning;light microscopy;Mechanics;Microtubules;Mitosis;Morphology;Motor Neurons;Muscle;mutant;Mutation;Nature;Neurites;Neurodegenerative Disorders;neurodevelopment;Neuromuscular Junction;Neurons;novel;Phenotype;Plus End of the Microtubule;Post-Translational Protein Processing;postmitotic;presynaptic;Presynaptic Terminals;Process;Property;protein complex;protein function;Proteins;Rattus;Research;RNA Interference;Role;Sensory;Shapes;Signal Transduction;Structure;Surface;Swelling;Synapses;synaptogenesis;System;Testing;Thinness;Vertebral column

PROJECT_TITLE: Kinetochore Protein Functions in Synaptogenesis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nanotechnology;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: PEABODY

ORG_NAME: PRIVO TECHNOLOGIES, LLC

PHR: RFA-CA-23-034 application entitled “Support for Registration Enabling Phase 3 Clinical Trial for Nanotechnology-Based Treatment of Carcinoma in Situ of the Oral Cavity (Stage 0 Oral Cancer)” Project Narrative: Privo’s Nanotechnology-Engineered PRV111 Transmucosal Delivery System delivers and retains high concentration of cisplatin directly in the tumor, with a safety and efficacy profile that has been proven through multiple sets of preclinical and a phase 1/2 clinical study in patients suffering from early-stage oral cancer. The treatment has been shown to be significantly safer and more effective than the standard of care, while demonstrating complete tumor regression in addition to maintaining a recurrence-free status for up to 36 months post-treatment. PRV111 administration does not require any specialized training and the treatment duration is ~10-15 minutes per patch application – with the funding from this proposal, Privo will conduct the registration enabling Phase 3 clinical trial to commercialize PRV111 and effectively eliminate the need for disfiguring surgery for Stage 0 oral cancer patients.

PI_NAMEs: GOLDBERG, MANIJEH N (contact);WEBB, MARCUS

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Address;Aftercare;Agreement;American Cancer Society;American Joint Committee on Cancer;Area;arm;Basement membrane;Biopsy;Blood;Businesses;Cancer Patient;Carcinoma;Carcinoma in Situ;Cessation of life;chemotherapeutic agent;Chemotherapy and/or radiation;Circulation;Cisplatin;Classification;Clinical;clinical development;Clinical Research;Clinical Trials;Combined Modality Therapy;commercialization;Cosmetics;cost;cytotoxicity;Data;Data Analyses;Databases;Deglutition;design;disability;Disease;Documentation;Dose Limiting;draining lymph node;Drug Controls;Drug Delivery Systems;Early Diagnosis;EGFR inhibition;Engineering;Enrollment;Ensure;Epithelium;Excision;follow-up;Funding;Goals;Human Papillomavirus;Impairment;improved;In Situ;Incidence;Institutional Review Boards;intravenous administration;Invaded;Label;Life;malignant mouth neoplasm;Malignant Neoplasms;manufacture;Manufactured Materials;Marketing;Medical;Monitor;Morbidity - disease rate;Mucous Membrane;nanoengineering;nanoparticle;Nanotechnology;Newly Diagnosed;open label;operation;Operative Surgical Procedures;Oral cavity;Oral Stage;oral tissue;Outsourcing;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Phase;Phase I/II Trial;Phase II Clinical Trials;Phase III Clinical Trials;physically handicapped;Polymers;Population;Positioning Attribute;pre-clinical;Preparation;Preventive;primary endpoint;Process;Protocols documentation;psychologic;Qualifying;Quality of life;Randomized;Readiness;recruit;Recurrence;response;Safety;Scientist;secondary endpoint;side effect;Site;Smoker;Source;Specific qualifier value;Speech;Squamous cell carcinoma;stability testing;standard of care;Stream;success;Surface;Survivors;System;systemic toxicity;Technology;Therapeutic;Time;timeline;Tissues;TNM;Tongue;Topical Chemotherapy;Toxic effect;Training;treatment arm;treatment duration;treatment effect;Treatment Side Effects;trial design;tumor;Tumor Tissue;Vendor;Visit

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Virulent phages play a major role in controlling the density of bacterial pathogens and, through a constant arms race, impact the evolution of pathogens. ICP3 is a virulent phage that preys on Vibrio cholerae within the human small intestine, and for which resistance is rarely observed. Here we will explore the genetic requirements of ICP3 for circumventing phage defense systems of V. cholerae.

PI_NAMEs: CAMILLI, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Antigens;arms race;Bacteria;Bacterial Infections;Bacteriophages;Bioinformatics;Cholera;Cholera Toxin;Classification;Clinical;Complement;cost;Cyclophosphamide;Data;Defense Mechanisms;deletion library;density;Development;Diarrhea;DNA Restriction-Modification Enzymes;Ecology;Environment;Etiology;Evolution;fitness;Funding Mechanisms;Future;Gene Deletion;Genes;Genetic;genetic analysis;Genome;genome sequencing;Host Defense;Host resistance;Human;Infection;insight;interest;Intestines;Libraries;Life Cycle Stages;lytic replication;Measures;Modeling;Multi-Drug Resistance;mutant;Open Reading Frames;pathogen;pathogenic bacteria;Patients;Play;Population;Predatory Behavior;prevent;Prevention;Prophylactic treatment;protein function;Proteins;receptor;Reporting;Resistance;resistance mechanism;Role;Small Intestines;Specificity;Structural Models;Suppressor Mutations;System;Testing;transposon sequencing;Validation;Vibrio cholerae;Vibrio cholerae O1;Virulence;Virulence Factors;Virulent;Virus;whole genome;Work

PROJECT_TITLE: Mechanisms by which ICP3 Overcomes Vibrio cholerae Phage Defenses

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: DOVER

ORG_NAME: COSMYC INC

ORG_STATE: DE

PHR: PROJECT NARRATIVE The goal of this project is to develop new cancer therapeutics that work by blocking the activity of the MYC oncogene. We have developed a revolutionary drug discovery platform that, for the first time, has enabled the screening and identification of promising small molecules that directly inhibit the cancer-promoting function of MYC. We will perform a series of in vitro and in vivo assessment of these hits to determine their suitability for progression towards a clinically relevant, novel, highly MYC-specific, and safe cancer therapy, which currently does not exist.

PI_NAMEs: FERIS, ED  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: 3-Dimensional;Amides;Amino Acid Motifs;Attenuated;Binding Sites;Biological Assay;Biological Availability;Biotechnology;Businesses;Cancer cell line;Cancer Patient;cancer therapy;career;cell growth;Cell Line;Cell Proliferation;Cells;Chemicals;cheminformatics;clinical development;clinically relevant;Co-Immunoprecipitations;commercialization;cytotoxicity;design;Development;Digit structure;Dose;drug discovery;Drug Kinetics;efficacy evaluation;efficacy study;efficacy testing;Evaluation;Future;Gene Targeting;Generations;Genes;Genetic Transcription;Goals;Grant;Growth;high throughput screening;Histone Acetylation;Human;improved;In Vitro;in vivo;Industry;inhibitor;insight;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Lead;lead optimization;lead series;Libraries;Ligand Binding;Lymphoma;Lymphoma cell;Malignant Neoplasms;Matrix Attachment Regions;MAX gene;Measures;Mediating;meter;Modeling;Molecular;mouse model;Multiple Partners;Mus;MYC gene;Nature;novel;Oncoproteins;Oral;Patients;Pharmaceutical Chemistry;Phase;phase 1 study;phase 2 study;prevent;Process;programs;protein complex;protein protein interaction;Proteins;Regimen;Research;safety study;Scientist;screening;Seminal;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Specificity;success;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Transactivation;transcription factor;Tumor Burden;tumor growth;tumorigenesis;Validation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Therapeutic Inhibition of MYC:TRRAP Interaction in Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (J2)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: LEBANON

ORG_NAME: DOSEOPTICS, LLC

ORG_STATE: NH

PHR: NARRATIVE Radiation therapy (RT) is generally considered safe and effective, but it is well known that deviations in treatment happen on a daily basis in a busy treatment facility, and these changes are prone to higher error rates. This project will fund the commercial readiness of a fundamentally new imaging system that allows the radiotherapy team to see the beam delivery on the patient’s tissue. It provides immediate feedback and review of treatments, to improve the quality of fractionated treatments by minimizing errors in daily delivery.

PI_NAMEs: WARE, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: Acceleration;Address;Adjuvant;Adoption;Agreement;Applications Grants;Area;Bolus Infusion;Breast;Businesses;Calibration;cancer therapy;chemotherapy;cherenkov imaging;Clinic;Clinical;Clinical assessments;clinical practice;commercialization;commercialization readiness;Communication;Computer software;Contralateral Breast;cost;Cost Savings;curative treatments;Data;data registry;demographics;Deposition;design;Detection;detection platform;Development;Dose;dosimetry;Engineering;Environment;Europe;experience;Feedback;fractionated radiation;Funding;Future;Generations;Goals;Grant;Health;Heart Atrium;human error;Image;imaging platform;imaging system;improved;in vivo;Incidence;Infrastructure;Intuition;invention;Investments;Label;Learning;Licensing;Light;Lighting;Malignant Neoplasms;manufacture;Marketing;member;Metric System;millimeter;Minor;Monitor;Names;Normal tissue morphology;operation;Operative Surgical Procedures;Optics;Parents;Patient Compliance;Patients;Persons;Phase;Photons;Positioning Attribute;post-market;Probability;prospective;Radiation Dose Unit;Radiation therapy;Readiness;Registries;Risk;Sales;Scientific Advances and Accomplishments;Second Primary Cancers;Secure;Services;side effect;Site;software systems;Source;statistics;Structure;supply chain;Surface;Surveys;System;Technology;Testing;Time;timeline;Tissues;tool;Trademark;Training;Translating;treatment planning;trend;United States National Institutes of Health;Update;usability;Validation;Vendor;Vermont;Visualization

PROJECT_TITLE: DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy Verification


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

PHR: Project Narrative The overarching goal of the Emory-Nigeria HIV Research Training Program (EN-RTP) is to enhance the capacity and the quality of researchers focused on HIV health issues relevant to women in Nigeria. To accomplish this, we will leverage existing collaborations between Emory University and three partnering Nigerian institutions to enhance human resource capacity enrichment with long-, medium-, and short-term research training of Nigerian investigators, facilitating their acquisition of the skills needed to pursue research careers focused on women’s health and HIV/AIDS.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;OFOTOKUN, IGHOVWERHA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adolescent health;Adult women;African;Age;Aging;AIDS prevention;Area;Award;Biomedical Research;Child;Chronic;Contraceptive Agents;Country;education research;Evaluation;experience;Faculty;Female of child bearing age;Fertility;Fostering;Funding;Goals;Grant;Growth;Habits;Health;HIV;HIV Infections;Infection;Infrastructure;Institution;International;life span;Medical Research;Menopause;Mentors;Mentorship;Methodology;Mother-to-child HIV transmission;multidisciplinary;next generation;Nigeria;Nigerian;Outcome;Peer Review;Persons;Pregnancy;Prevention;Process;Productivity;programs;Publications;Reporting;reproductive;Reproductive Health;Research;Research Personnel;Research Training;Scientist;Scourge;skills;Structure;Therapeutic;Training;Training Programs;United States National Institutes of Health;Universities;Woman;Women's Health;women's morbidity;Women's mortality;young woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-S (55)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Patient Safety;Prevention

ORG_NAME: LEUKO LABS, INC.

PHR: PROJECT NARRATIVE PointCheckTM is the first medical device that non-invasively detects immunosuppression resulting from cancer chemotherapy, without the need for a blood sample. It uses optics to image through the skin and enable self- administered and quick testing. Use of PointCheck in patients’ homes and outpatient cancer clinics will provide early detection and enable prompt medical care to prevent life-threatening infections in cancer patients undergoing chemotherapy.

PI_NAMEs: CASTRO-GONZALEZ, CARLOS  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Accident and Emergency department;Adoption;Algorithms;Anti-Infective Agents;artificial intelligence algorithm;automated analysis;Blood;Blood capillaries;Blood flow;Blood specimen;Cancer Patient;care outcomes;Caring;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Classification;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;Colony-Stimulating Factors;commercialization;Communication;Contracts;cost;cyber security;Data;data acquisition;Death Rate;design;Device Designs;Devices;diagnostic accuracy;Dose;Early Diagnosis;Early Intervention;Electromagnetics;experience;Feasibility Studies;Fever;fighting;Fingers;Goals;Growth;Healthcare;Home;hospital readmission;Hospitalization;Hospitals;Image;Immunosuppression;improved;Incidence;Infection;Intervention;Interview;Leukocytes;Life;Malignant Neoplasms;Manuals;manufacture;Manufacturer;Marketing;Measurement;Measures;Medical;Medical Device;meetings;Microcirculation;Monitor;Morbidity - disease rate;mortality risk;Neutropenia;neutrophil;Non-Invasive Detection;non-invasive optical imaging;Notification;novel;Oncology;Optics;Outcome;Outcome Study;Outpatients;Pathway interactions;Patient Compliance;Patients;Performance;Phase;point of care;portability;prevent;primary endpoint;Production;Protocols documentation;prototype;Questionnaires;Reagent;Recording of previous events;remote grading;Research Design;Risk;risk minimization;Safety;scale up;secondary endpoint;Self Administration;Sensitivity and Specificity;Skin;Small Business Innovation Research Grant;Specific qualifier value;Specificity;success;System;Technology;Test Result;Testing;Treatment Side Effects;Triage;usability;Validation;Video Microscopy;Visit;Work

PROJECT_TITLE: Reducing the incidence of febrile neutropenia in cancer patients treated with chemotherapy with PointCheck: a portable non-invasive neutropenia analyzer


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Natural Products;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ORLANDO

ORG_NAME: HESPEROS, LLC

PHR: Project Narrative The goal of this project is to utilize our human neuromuscular junction (NMJ) platform to replace the mouse lethality bioassay (MLB) currently used to determine potency of commercial batches of Botox. A high throughput platform will be validated and then submitted to the FDA for qualification. We will use nanotechnology and microelectronics in combination with biomedical engineering techniques to build these hybrid 3D biological/non- biological systems.

PI_NAMEs: HICKMAN, JAMES J;KRONAUGE, JAMES F (contact)

PROGRAM_OFFICER_NAME: KREPKIY, DMITRIY

PROJECT_TERMS: 3-Dimensional;Address;Animals;Astrocytes;Axon;Biological;Biological Assay;Biological Models;Biomedical Engineering;Bladder;Blinded;body on a chip;Botulinum Toxins;Bungarotoxins;Case Study;cell type;Cells;chromatin immunoprecipitation;Chronic;Chronic Inflammatory Demyelinating Polyneuropathy;Clinical;clinically relevant;commercialization;Consultations;Cosmetics;Curare;Data;design;Disease;disease model;dosage;Dose;drug development;drug discovery;Drug Kinetics;Electronic Mail;Ensure;Evaluation;experience;Fatigue;Future;Genetic Variation;Goals;Grant;Human;Human Resources;human stem cells;Hybrids;Hyperactivity;imaging system;Immune system;In Vitro;in vivo;Incubators;indexing;induced pluripotent stem cell;Inflammation;innovation;Legal patent;Letters;Licensing;Link;Marketing;Measurement;microelectronics;Microglia;microphysiology system;Migraine;mitochondrial dysfunction;Modeling;Monitor;Motion;Motor Neurons;Multifocal Motor Neuropathy;Mus;Muscle;Muscle Contraction;Muscle Spasticity;Mutation;Myasthenia Gravis;Nanotechnology;National Center for Advancing Translational Sciences;Nervous System Disorder;Neuromuscular Junction;Oxidative Stress;Paper;Pathology;Patients;Persons;Pharmacodynamics;Pharmacologic Substance;Phase;Phase II Clinical Trials;Phenotype;Physiological;potency testing;pre-clinical;pre-clinical research;Predisposition;Process;programs;Provider;Publications;Publishing;Qualifying;real-time images;Reflex action;Regulatory Pathway;Research Contracts;response;Route;Sampling;Schwann Cells;screening;Services;Side;Site;Skeletal Muscle;Small Business Innovation Research Grant;Source;Strabismus;Sweating;symptom treatment;System;Techniques;Technology;Testing;Therapeutic;three-dimensional modeling;Time;Tissue Microarray;tool development;Toxic effect;Toxicology;Toxin;United States National Institutes of Health;Validation

PROJECT_TITLE: Human NeuromuscularJunction Platform to Evaluate Botulinum Toxin Potency

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 SBIR-5 (04)]


ORG_CITY: TENAFLY

ORG_NAME: ARMA BIO, INC.

ORG_STATE: NJ

PHR: Narrative Prostate cancer is the second most commonly diagnosed cancer in men in the U.S. and is responsible for about 34,000 deaths and an economic toll of $13 billion each year. To treat men whose cancer has advanced to castration-resistant prostate cancer, Arma Bio is developing dual inhibitors of the full-length androgen receptor (AR-fl) and AR-V7, the most prevalent splice variant in men with this cancer. A dual inhibitor that can overcome drug resistance will offer a much-needed therapeutic option for men with castration-resistant prostate cancer, ultimately improving clinical outcomes.

PI_NAMEs: AU, CHEUK MAN CHERIE  (contact)

PROJECT_TERMS: abiraterone;Acceleration;Address;advanced prostate cancer;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Animals;Biological;Biological Assay;Biological Availability;biomarker development;Businesses;cancer cell;cancer diagnosis;Cancer Etiology;candidate selection;career;Castration;Cell Nucleus;Cessation of life;Clinic;Clinical;clinical biomarkers;Coupled;Data;deprivation;design;Development;Diagnosis;Disease;Dose;drug candidate;Drug Kinetics;Drug resistance;Economic Burden;Economics;efficacy evaluation;efficacy study;enzalutamide;experimental study;Foundations;Glues;Goals;Grant;Growth;improved;In Vitro;in vivo;Incidence;inhibitor;inhibitor therapy;Knowledge;Lead;lead candidate;Length;Ligand Binding Domain;Male Castration;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Marketing;Maximum Tolerated Dose;Mediating;men;Metastatic Prostate Cancer;meter;Modeling;Molecular;Mus;nanomolar;Neoplasm Metastasis;Normal Cell;novel therapeutics;Oral;Oral Administration;Outcome;patient derived xenograft model;patient population;Patients;Pharmaceutical Chemistry;pharmacologic;Phase;Phase I/II Clinical Trial;Phenocopy;Phenotype;Positioning Attribute;prevent;profiles in patients;Progression-Free Survivals;Proteins;Rattus;Receptor Signaling;Resistance;Resistance development;RNA Splicing;Safety;Scientist;Signal Transduction;small molecule;small molecule inhibitor;small molecule therapeutics;standard of care;Structure-Activity Relationship;survival outcome;synergism;taxane;Testing;Therapeutic;therapeutic target;therapy resistant;Toxic effect;Toxicology;tumor growth;Variant;Work;Xenograft procedure

PROJECT_TITLE: Development of small molecule therapeutics targeting AR-V7 for prostate cancer


ORG_CITY: ALLSTON

ORG_NAME: APERTURE BIO, INC.

PHR: PROJECT NARRATIVE Nearly two thirds of new cancer patients fail treatment due to resistance that is not fully understood. Aperture Bio’s single cell proteomics platform can provide rapid single-cell molecular analyses to enable improvements over current diagnostics, ultimately improving patient treatment options and outcomes. This project further develops and validates the proprietary technology in addition to producing new, proprietary analytical software to create a comprehensive tumor T cell panel, with the ultimate goal of ensuring that every lab can employ single cell methods.

PI_NAMEs: PETERSON, HANNAH MARIE (contact)

PROJECT_TERMS: Acceleration;Adoption;Agreement;Algorithms;Antibodies;antibody libraries;Award;Benchmarking;Binding;Biological Markers;biomarker development;Biopsy Specimen;Biotechnology;cancer infiltrating T cells;Cancer Patient;career;Cells;Chemistry;Clinical;Clinical Trials;Collection;commercialization;Complex;Computational algorithm;Computer software;cost;Cytometry;Data;design;Development;Diagnostic;diagnostic tool;Drug Targeting;Elements;Ensure;Entrepreneurship;experimental study;Fine needle aspiration biopsy;Flow Cytometry;Fluorescence;fluorophore;Future;General Hospitals;Goals;head-to-head comparison;Image;Immune;Immunofluorescence Immunologic;Immunology;improved;Innovation Corps;interoperability;Label;Libraries;Marketing;Massachusetts;Mentorship;Methods;Microscope;Molecular Analysis;next generation;novel;Oncologist;Oncology;Outcome;Pathology;Patient Selection;Patients;Phase;Population;Precision cancer therapy;precision oncology;preservation;Principal Investigator;product development;Production;programs;Property;protein expression;Proteomics;Protocols documentation;Regenerative Medicine;Reproducibility;Research;research and development;Resistance;Resources;response;Running;Sample Size;Sampling;Series;Services;Signal Transduction;single cell analysis;Solid Neoplasm;Source;Stains;Suspensions;T-Lymphocyte;Technology;Testing;timeline;tool;Translating;Treatment outcome;tumor;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: WINCHESTER

ORG_NAME: BOSTON IMMUNE TECHNOLOGIES AND THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE TNFR2 is an extremely promising target for therapy in multiple cancers. However, current strategies aimed at TNFR2 targeting fail to shut down its pro-survival signaling. BITT is advancing a first-in-class dominant antagonist to TNFR2 with potent anti-tumor effect to clinical testing.

PI_NAMEs: BROOKS, DAVID G (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;advocacy organizations;Animal Model;antagonist;Antibodies;antitumor effect;Award;Biological Markers;biomarker evaluation;Birds;Blood specimen;Boston;burden of illness;cancer cell;Cancer Patient;cancer therapy;Cells;cGMP production;Clinical;clinical application;Clinical Trials;Collaborations;Cutaneous T-cell lymphoma;Cyclic GMP;design;Development;Diagnosis;dimer;dosage;Dose;Drug Kinetics;Enrollment;Enzyme-Linked Immunosorbent Assay;Feedback;Fibroblasts;Frequencies;Funding;Growth;Health;Health Expenditures;Immune;Immuno-Chemotherapy;Immunooncology;Infiltration;innovation;Institution;interest;International;Macaca fascicularis;malignant lymphocyte;Malignant Neoplasms;manufacture;Marketing;Measures;Mediating;Medical center;Molecular Target;Monoclonal Antibodies;Non-Hodgkin's Lymphoma;novel;novel strategies;novel therapeutics;overexpression;Pathway interactions;patient response;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Pharmacologic Substance;Phase;pre-clinical;predicting response;prevent;Privatization;Production;Prognostic Factor;Prognostic Marker;prognostic significance;receptor;Receptors, Tumor Necrosis Factor, Type II;Regulatory Affairs;Regulatory T-Lymphocyte;research clinical testing;Resistance;Resistance development;response;Safety;Secure;selective expression;Serum;Signal Transduction;Small Business Innovation Research Grant;Surrogate Markers;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy outcome;Time;Tissues;TNFR-Fc fusion protein;Toxicology;trial planning;tumor;Tumor Markers;tumor microenvironment;Tumor Necrosis Factor Activation;tumor necrosis factor receptor binding;Tumor Promotion;Validation

PROJECT_TITLE: Biomarker Rich Clinical Trial of an Innovative Antibody Antagonist of TNFR2 in Non-Hodgkin Lymphoma Featuring Cutaneous T Cell Lymphoma (CTCL).


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Cannabinoid Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: S-3 RESEARCH, LLC

PHR: 1.b. PROJECT NARRATIVE. Cannabis, i.e., marijuana, is the most used drug substance in the United States, yet the illicit black market for cannabis-derived products continues to dominate sales in states where it is now legalized. Lack of policy coherence on cannabis legalization has led to unregulated new product introduction and illegal sales on the Internet, introducing the potential for consumer harm and threatening the business viability of legitimate and licensed cannabis providers. In response, the proposed project will leverage advanced methods in big data, machine learning, and data visualization to develop a multiplatform compliance solution to detect and report illegal online sellers of cannabis products.

PI_NAMEs: MACKEY, TIMOTHY KEN (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: 12 year old;Address;Algorithms;American;Artificial Intelligence;Big Data;Businesses;Cannabidiol;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;Chemicals;Classification;commercialization;Confusion;Consumption;cost efficient;Dangerousness;Darkness;Data;Data Collection;data dashboard;data platform;data visualization;Databases;Dedications;Detection;detection platform;Development;digital;Drug usage;e-commerce;Ensure;Evaluation;evaluation/testing;experience;Feedback;Floods;Funding;Future;Harm Reduction;Health;Hemp;improved;Industry;innovation;Internet;Law Enforcement;Legal;Licensing;Licensure;Machine Learning;machine learning algorithm;Marijuana;marijuana legalization;marijuana use;Marketing;Measures;Medical;Medical Marijuana;Methods;Modeling;Monitor;National Institute of Drug Abuse;novel;novel strategies;Opioid;Police;Policies;prevent;Prevention;Property;Protocols documentation;Provider;Public Health;Recreation;Regulation;Reporting;Research;response;Risk;Safety;Sales;Services;Site;Small Business Innovation Research Grant;social media;success;supply chain;System;Technology;Testing;Tetrahydrocannabinol;tool;training data;United States;Vendor;virtual;Visualization software;Voting;web-enabled;Work

PROJECT_TITLE: WeeDetection:  Multi-platform Detection System to Identify and Report Illegal Sales of Cannabis-derived Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The growing discovery of genomic loci associated with psychiatric disorders allows the generation of polygenic risk scores (PRS) which could help identify individuals at increased risk for a psychiatric disorder and potentially prevent or delay disease onset, and minimize morbidity and risk for suicide. However, the use of PRS in child and adolescent psychiatry, and its ethical and legal implications remain understudied. To promote responsible use of psychiatric PRS in children and adolescents, we will use a mixed-methods approach that includes qualitative, quantitative, and legal analysis to: 1) give voice to stakeholders (i.e., patients, parents/caregivers, clinicians) by examining their perspectives regarding whether psychiatric PRS should be used and, if so, how; and 2) examine the legal and regulatory landscape to identify what privacy and genetic discrimination safeguards may be necessary.

PI_NAMEs: LAZARO-MUNOZ, GABRIEL ;PEREIRA, STACEY  (contact);STORCH, ERIC A.

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: 18 year old;Address;Adolescent;adolescent patient;Adolescent Psychiatry;Adult;Age;autism spectrum disorder;Behavior;Biomedical Technology;Caregivers;Cause of Death;Child;Child Psychiatry;Clinical;clinical care;Collaborations;court;Data;design;disability;Discrimination;Disease;Early identification;Early Intervention;emerging adult;ethical, legal, and social implication;Ethics;experience;Funding;Future;General Population;Generations;Genetic;genetic discrimination;genetic information;genetic testing;genomic locus;Goals;Guidelines;improved;Individual;innovation;Intervention;Interview;Laws;Legal;legal implication;Mental Depression;Mental disorders;Methods;Minor;Monitor;Morbidity - disease rate;Onset of illness;Other Genetics;Outcome;Parents;Patients;Persons;Policies;polygenic risk score;Population;predictive tools;prevent;Prevention;Privacy;privacy protection;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;psychogenetics;Recording of previous events;Research;research study;Risk;risk prediction;Schizophrenia;Schools;social;social stigma;societal costs;stakeholder perspectives;suicidal risk;Surveys;tool;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Polygenic Risk Scores in Child and Adolescent Psychiatry: Ethical, Clinical, and Legal Implications


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Heart failure (HF) is present in 5% of veterans, represents a major health and economic burden, with 80% of care costs attributable to hospitalizations. Reduction of HF readmissions has been identified as a major VA strategic goal. Remote monitoring has shown promise in reducing readmissions. In a pilot multicenter study, we demonstrated that remote monitoring using a small wearable sensor has a high compliance rate and provides accurate early detection of impending HF readmissions for HF. In this next step, we propose to implement non- invasive remote monitoring within the VA system with an algorithmic response to the device alert and an ongoing validation and update of the response algorithm as part of the learning health-care system concept. Furthermore, we will conduct a feasibility study of clinical efficacy. Our results will be directly applicable to care of HF patients and to designing remote monitoring strategies for chronic health conditions within and outside the VA system.

PI_NAMEs: STEHLIK, JOSEF  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;Algorithms;arm;Attitude;Behavior;care costs;Caring;Cellular Phone;Characteristics;Chronic;Classification;Clinic;Clinic Visits;Clinical;clinical efficacy;clinical implementation;clinical practice;Clinical Trials;clinically actionable;Congestive Heart Failure;cost;Cost Effectiveness Analysis;Data;design;Detection;Devices;Dimensions;Early Diagnosis;Economic Burden;Effectiveness;Electronic Health Record;Eligibility Determination;Emergency department visit;Enrollment;Equipment;Evaluation;Fatigue;Feasibility Studies;Focus Groups;formative assessment;Funding;Future;Goals;Health;Health Care Costs;health related quality of life;Healthcare Systems;Heart failure;high risk;hospital readmission;Hospitalization;hospitalization rates;Hospitals;implementation design;implementation determinants;implementation evaluation;implementation fidelity;implementation intervention;implementation outcomes;implementation process;implementation strategy;implementation study;improved;improved outcome;innovation;Instruction;Intervention;Interview;Knowledge;Learning;Length of Stay;Link;Machine Learning;Medical center;Methodology;Monitor;monitoring device;Multicenter Studies;Notification;Outcome;Outcome Study;Outpatients;Participant;Patient-Focused Outcomes;Patients;Penetration;Perception;Performance;Pharmaceutical Preparations;Phase;Physiological;Pilot Projects;prediction algorithm;Predictive Analytics;Process;programs;Promoting Action on Research Implementation in Health Services framework;Protocols documentation;Provider;provider communication;Qualitative Research;Quality of life;Randomized;Recommendation;remote monitoring;Research Methodology;response;Risk;Safety;satisfaction;Secure;sensor;Services;Site;Source;Standardization;Stream;Structure;Study Subject;System;Technology;Technology Assessment;Telemetry;Testing;Time;treatment arm;Treatment Failure;treatment response;Update;Validation;Variant;Veterans;wearable monitor;wearable sensor technology;Work

PROJECT_TITLE: Continuous Wearable Monitoring Analytics to Improve Outcomes in Heart Failure - LINK-HF2 multicenter implementation study

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Bioengineering;Clinical Research;Diabetes;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: This project will contribute knowledge pertinent to the cause of excess risk of osteoporotic fractures in patients with insulin-dependent diabetes mellitus. We will obtain transilial bone biopsies from type-1 diabetics in which to measure content of known chemicals that weaken bones, and compare those same measurements in matched, normal, nondiabetic subjects. Since practitioners and pharmaceutical companies are not yet convinced of their importance, results from this project will encourage performance of the expensive clinical trials needed to provide agents that reduce fracture risk in diabetics.

PI_NAMEs: AKHTER, MOHAMMED PERVEZ (contact);ARMAS, LAURA ANNE GRAEFF

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Adult;Advanced Glycosylation End Products;Age;Animal Model;Binding;Biopsy;blood glucose regulation;Body mass index;bone;Bone Density;bone loss;bone mass;Bone Tissue;Chemicals;Clinical Trials;Collagen;Communities;cortical bone;crosslink;Data;Defect;density;Development;diabetes control;Diabetes Mellitus;diabetic;Documentation;Enrollment;Epidemic;FDA approved;Female;Fracture;fracture risk;glycation;Glycosylated Hemoglobin;Goals;Hardness;Heterogeneity;high risk;Hyperglycemia;Image;improved;Incidence;Insulin-Dependent Diabetes Mellitus;interest;Knowledge;Measurement;Measures;mechanical properties;Mechanics;Modulus;nanoindentation;non-diabetic;Osteocytes;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Patients;pentosidine;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Population;Postmenopause;Prevention;Preventive;pyridinoline;Raloxifene;recruit;Reducing Agents;Relative Risks;Resolution;Risk;secondary analysis;secondary outcome;Serum;sex;Shapes;skeletal;substantia spongiosa;Testing;Therapeutic;therapy development;Three-Dimensional Imaging;Time;Tissues;Trauma;type I diabetic;Variant;Water;Woman;Work

PROJECT_TITLE: Skeletal Effects of Type 1 Diabetes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE  Opioid Use Disorder (OUD) is a major public health concern in the United States with a record number of opioid-related deaths in 2020 and limited therapeutics for treatment. Discovery-based genetics combined with pharmacological and neurobiological approaches in rodent model organisms are critical for understanding molecular mechanisms underlying susceptibility to OUDs. Our project’s goal in understanding the genetic basis of oxycodone metabolism and addiction model behaviors through a multidisciplinary approach has direct translational relevance to humans and personalized medicine, both in opioid therapeutics and OUD treatments.

PI_NAMEs: LYNCH, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Accounting;addiction;adeno-associated viral vector;Analgesics;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Brain;brain tissue;Candidate Disease Gene;candidate validation;causal variant;Cessation of life;Chromosome 15;Chromosome Mapping;Clinical;Code;Complex;conditioned place preference;Corpus striatum structure;CRISPR/Cas technology;CYP2D6 gene;Cytochrome P450;Data;DNA Insertion Elements;drug metabolism;Elements;Environment;Enzymes;Epidemic;Excision;Female;Genes;Genetic;genetic manipulation;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Genotype;Goals;Harvest;Hepatic;Heritability;High Pressure Liquid Chromatography;Hippocampus;Homeobox;Human;in vivo;Inbred BALB C Mice;Inbred Mouse;individualized medicine;insight;interdisciplinary approach;Learning;Link;Liver;Liver Extract;liver metabolism;Locomotion;Maps;Mass Spectrum Analysis;Messenger RNA;Metabolism;model organism;Modeling;Molecular;Monitor;mouse genetics;Mus;Neurobiology;novel;Opiate Addiction;Opioid;opioid mortality;opioid use disorder;Oral;Orthologous Gene;overexpression;Oxycodone;Oxymorphone;personalized medicine;pharmacologic;Phenotype;Plasma;Predisposition;prescription opioid;Privatization;Production;protein expression;Proteins;Proteome;Proteomics;Public Health;Quantitative Trait Loci;Regulation;Rewards;Rodent;rodent genome;Rodent Model;Role;Sample Size;Self Administration;Site;small hairpin RNA;Substance Use Disorder;System;Testing;Therapeutic;therapeutic opioid;Therapeutic Uses;Tissues;Training;trait;Transcription Repressor;transcriptome;transcriptome sequencing;transcriptomics;United States;Validation;Variant;Zinc deficiency;Zinc Fingers

PROJECT_TITLE: The role of Zhx2 in CYP2D regulation, oxycodone metabolism, and opioid addiction model behaviors.


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Elite controllers represent a model for a functional cure of HIV-1 infection, but underlying mechanisms enabling such a remarkable disease outcome are ill-defined. Here, we propose to use novel next-generation sequencing technologies to analyze the molecular profile of viral reservoir cells in elite controllers.

PI_NAMEs: YU, XU  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Age;Allogeneic Bone Marrow Transplantation;Anti-Retroviral Agents;ATAC-seq;Behavior;biocomputing;Biological Assay;Blood;CCR5 gene;Cells;Cellular Assay;Characteristics;ChIP-seq;Chromatin;chromosomal location;Cleavage Under Targets and Release Using Nuclease;clinical development;Complex;Data;design;Disease Outcome;Disease remission;DNA;DNA Methylation;Epigenetic Process;experimental study;Frequencies;Genetic;Genetic Transcription;Genome;genome analysis;genome-wide;genomic locus;Genomic Segment;Goals;Hematopoietic stem cells;Histones;HIV;HIV-1;HLA Class I Genes;Human;Human Genome;Hypermethylation;Immune;Immune response;Immunologics;in vivo;Individual;Infection;innovation;integration site;interest;Intervention;Link;longitudinal analysis;Lymphoid Tissue;Mediating;Methylation;Modeling;Molecular Profiling;Nature;next generation sequencing;novel;Pathogenicity;patient population;Peripheral Blood Mononuclear Cell;permissiveness;Pharmaceutical Preparations;Predisposition;promoter;Proviruses;Reporting;Research;Resistance;RNA;Signal Transduction;Site;Stem cell transplant;Stimulus;Structure;Study models;Techniques;Technology;Testing;Time;Tissues;Variant;Viral;Viral Genes;Viral Load result;Viral reservoir;Viremia;Virus

PROJECT_TITLE: Elite controllers as a model for a cure of HIV-1 infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The current proposal will establish a powerful non-invasive imaging biomarker based on development of rapid, simultaneous multiparametric relaxation mapping of knee joint with magnetic resonance fingerprinting (MRF).

PI_NAMEs: REGATTE, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Abdomen;Affect;Agar;articular cartilage;Base Sequence;Biochemical;Brain;Cardiac;Cartilage;cartilage degradation;Cattle;Clinical;clinical application;Clinical Protocols;Collagen;Collagen Fiber;Contrast Media;Data;data acquisition;Data Correlations;Debility;Degenerative polyarthritis;density;Development;Diagnosis;Dictionary;Disease;Disease Progression;Early Diagnosis;Evolution;Extracellular Matrix;Fingerprint;follow-up;Future;Gel;Goals;Healthcare Systems;Hip region structure;Image;imaging biomarker;improved;in vivo;Individual;interest;joint destruction;KITLG gene;Knee joint;Knee Osteoarthritis;Lead;macromolecule;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measures;Modeling;Morphology;Noise;Non-Invasive Detection;non-invasive imaging;novel;Pathologic Processes;Pathology;Patient Outcomes Assessments;Patients;Pattern;Pattern Recognition;Persons;Physiologic pulse;Population;Preparation;Property;Prostate;Proteoglycan;Protocols documentation;Protons;Quantitative Evaluations;Radial;Relaxation;Reproducibility;Research;Sampling;Scanning;Signal Transduction;simulation;System;Techniques;therapeutic evaluation;Time;Tissues;Training;Translating;United States;Validation;Variant;Vendor

PROJECT_TITLE: Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Rural Health;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: GOLDEN

ORG_NAME: KLEIN BUENDEL, INC.

ORG_STATE: CO

PHR: Project Narrative School interventions to reduce bullying can be effective but also require substantial time and resources. Online technologies have the potential to deliver effective bullying interventions to a large number of middle school students for less cost. The feasibility of delivering the effective STAC bullying intervention through a mobile web app will be tested using focus groups with middle school students and development and usability testing and the efficacy of the program will be tested using a randomized controlled trial.

PI_NAMEs: MIDGETT, AIDA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Algorithms;Anxiety;Behavior;behavior change;bullying;bullying prevention;Canada;Categories;commercialization;Communities;Compassion;Computers;cost;cyberbullying;design;Development;digital health;E-learning;effectiveness testing;efficacy testing;elementary school;experience;Feedback;Focus Groups;health communication;Household;Human Resources;implementation barriers;Improve Access;improved;Income;Injury;innovation;Intervention;Interview;Investigation;junior high school;Knowledge;Language;Low income;Marketing;media use;Mental Depression;Mental Health;Middle School Student;Mississippi;Nature;Outcome;Persons;Phase;Prevention approach;Privatization;Program Sustainability;programs;prototype;Randomized, Controlled Trials;Reporting;Research;research and development;Research Personnel;Resources;Risk;Robin bird;Role;Rural;Rural Community;scale up;Schools;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Spanish/English;statistics;Students;Technology;technology intervention;Testing;Theft;Time;Training;Translating;Translations;United States;Universities;uptake;urban area;usability;user centered design;Victimization;web app;Woman;Work;Youth

PROJECT_TITLE: Translating an In-Person Brief, Bystander Bullying Intervention (STAC) to a Technology-Based - Phase II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-D(16)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Data Science;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative In cancer research, the need for a diverse pool of researchers in statistics and data science has never been greater, but the requisite academic pipeline for training such a workforce remains inadequate. GROWS@FredHutch (Generating Research Opportunities Within Statistics at Fred Hutch) is a summer mentored research program for undergraduate students who identify as underrepresented minorities, and will include an engaging and supportive mentored research experience along with career development, community building, and social/emotional support activities to encourage students to (1) gain skills and confidence in cancer statistics and data science and (2) feel a sense of belonging and rightful place in the statistics and cancer research communities. The goal of GROWS will be to promote a diverse workforce to ensure that future cancer researchers will represent our broader community, including populations disproportionately impacted by cancer.

PI_NAMEs: CHOWNING, JEANNE TING;ETZIONI, RUTH D;OTHUS, MEGAN  (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acute;Address;Admission activity;American;anti-cancer research;Area;Automobile Driving;Awareness;Bachelor's Degree;Biometry;Black race;cancer statistics;care outcomes;career;career development;Code;Communities;community building;community partnership;COVID-19 pandemic;Data Science;Disparity population;Diverse Workforce;Educational workshop;Emotional;Environment;equity, diversity, and inclusion;ethnic minority;experience;Faculty;faculty mentor;Fostering;Foundations;Fred Hutchinson Cancer Research Center;Future;Goals;Graduate Degree;health care availability;health inequalities;Hispanic;Home;Immigrant community;improved;Individual;interest;Internships;Leadership;Malignant Neoplasms;marginalized population;Mentors;Methods;Minority;minority student;Mission;next generation;Participant;Population;Positioning Attribute;Principal Investigator;programs;Psychological reinforcement;Qualifying;racial minority;Recording of previous events;recruit;Research;Research Personnel;role model;Science;science education;Services;skills;social;sound;Statistical Data Interpretation;statistics;student mentoring;Students;success;summer internship;summer research;Time;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;volunteer

PROJECT_TITLE: Generating Research Opportunities Within Statistics at Fred Hutch (GROWS@FredHutch)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In this application we propose to validate a positron emission tomography (PET) imaging agent for use in Alzheimer's disease research. As the sigma-1 receptor is involved in many diseases including Alzheimer's, the use of PET imaging to investigate the receptor and its changes in diseases will provide a potentially valuable tool to diagnose Alzheimer's disease and or early stage, and to monitor disease progression and treatment outcomes.

PI_NAMEs: HUANG, YIYUN HENRY (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Age;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Animal Disease Models;Animal Diseases;Apolipoproteins;Applications Grants;Autoradiography;Binding;Biochemical;Bioenergetics;Biological Markers;Brain;Calcium;calcium metabolism;Calcium Signaling;Cells;Cessation of life;Cholesterol Homeostasis;cholinergic;Clinical;Clinical Trials;cognitive function;Complex;Coupled;Data;Degenerative Disorder;Dementia;density;Development;Diagnosis;Diagnostic;Disease;disease mechanisms study;Disease Progression;donepezil;Dose;dosimetry;drug candidate;Drug Kinetics;Drug Targeting;early detection biomarkers;Early Diagnosis;enantiomer;Endoplasmic Reticulum;Equilibrium;Etiology;Evaluation;experience;experimental study;first-in-human;Functional disorder;Generations;Genetic Polymorphism;glucose-regulated proteins;healthy volunteer;Human;human study;human subject;Huntington Disease;hyperphosphorylated tau;Image;imaging agent;Immune response;Immunoglobulin binding proteins;improved;in vivo;inorganic phosphate;Inositol;insight;Investigation;ITPR1 gene;Kinetics;Label;Ligands;Link;lipid metabolism;Measurement;Mediating;Membrane;Mental Depression;Mental disorders;Methods;mild cognitive impairment;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Chaperones;Monitor;Monkeys;Morphology;mouse model;Nerve Degeneration;Nervous System Disorder;neural;Neurofibrillary Tangles;Neurons;neuroprotection;neuropsychiatric disorder;nonhuman primate;novel;novel therapeutics;Oral;Organ;Oxidative Stress;Oxidative Stress Induction;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Persons;pharmacologic;Play;Positron-Emission Tomography;pre-clinical;Procedures;Production;Proteins;Protocols documentation;radiochemical;radioligand;Reaction;receptor;Receptor Gene;Regulation;Reproducibility;Research;Risk Factors;Rodent;Role;Scanning;Schizophrenia;sigma-1 receptor;Signal Transduction;Skeleton;Slice;Specificity;Surrogate Markers;Synapses;Synaptic Vesicles;tau Proteins;Testing;therapeutic development;therapeutic target;tool;Toxic effect;Toxicology;Translational Research;Translations;Treatment outcome;whole body imaging;Work

PROJECT_TITLE: Sigma-1 Receptor Radioligand for Translational Research in Alzheimer's Disease

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Hematology

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Von Willebrand factor (VWF) is important to mediate the process of thrombus formation, which can stop bleeding after injury, but can also cause vascular occlusion in diseased blood vessels. We will develop multidisciplinary approaches to directly observe flow-induced shape change in VWF, and study its effects on the properties of VWF binding to its partners. This work will establish much-needed laboratory models for human bleeding disorders and thrombosis, and improve our fundamental understanding of how our bodies sense the physical world and respond in specific ways to prevent disease.

PI_NAMEs: FU, HONGXIA  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: ADAMTS;Adhesions;Atomic Force Microscopy;Behavior;Binding;Biophysics;Blood;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;body sense;Coagulation Process;Complex;Data;Disease;Dissociation;disulfide bond;Event;Factor VIII;Fibrin;Fluorescence;Fluorescence Microscopy;Goals;Hematological Disease;Hemorrhage;high risk;Human;Image;imaging modality;immunogenicity;improved;Individual;Infusion procedures;Injury;insight;interdisciplinary approach;Intravenous infusion procedures;Label;Laboratories;Left;Link;Location;Magnetism;Maps;Measures;Mediating;Methods;Microfluidics;Microscopy;Modeling;Molecular;Molecular Conformation;monomer;Mutation;nanometer;Patients;Plasma;Polysaccharides;Preparation;preservation;prevent;Process;Property;Proteins;Reporting;Role;Sampling;Shapes;single molecule;Spectrum Analysis;structural determinants;Structure;superresolution imaging;System;therapeutic development;Thrombin;Thrombosis;Thrombus;Visualization;von Willebrand Disease;von Willebrand Factor;Work

PROJECT_TITLE: Mechanisms of interactions between von Willebrand factor and its binding partners

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  The development of new catalytic stereoselective glycosylation methods enables efficient access to homogenous, structurally well-defined, biologically important carbohydrate molecules for potential treatment of myeloma cancer and for advancing an understanding of their biological functions in neural development.

PI_NAMEs: NGUYEN, HIEN M (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Development of Catalytic Glycosylations and Biologically Important Glycosaminoglycans

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: If our hypothesis is true, we expect that the telomere biomarker will identify the subset of men who would be less likely to benefit from aggressive salvage therapy – either because their disease biology is such that their cancer would not have progressed irrespective of the use of aggressive salvage therapy or because their disease biology is such that their cancer would have progressed despite use of aggressive salvage therapy. Further, we expect that men not in either of these categories would be more likely to benefit from aggressive salvage therapy. Thus, if the telomere biomarker were incorporated into precision treatment decision-making, men in the first subset could be spared unnecessary treatment and side effects, while men in the latter subset would benefit from the use of aggressive salvage therapy.

PI_NAMEs: HEAPHY, CHRISTOPHER M;MEEKER, ALAN KEITH (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Age;Anti-androgen Therapy;Biochemical;Biological Markers;Biology;Boston;cancer cell;Cancer Therapy Evaluation Program;Categories;cell type;Cells;Cessation of life;Clinic;Clinical;clinical practice;cohort;Coupled;Cox Models;Decision Making;Diagnosis;Disease;Distant Metastasis;Event;first-in-human;Hospitals;Image;Image Analysis;Immunofluorescence Immunologic;innovation;Length;Malignant neoplasm of prostate;Malignant Neoplasms;man;Medical center;men;Neoplasm Metastasis;Operative Surgical Procedures;Pathology;Patients;Pattern;Placebos;practice setting;Precision therapeutics;Prediction of Response to Therapy;predictive marker;Prognosis;prognostic;prognostic indicator;Prognostic Marker;prospective;Prostatectomy;quantitative imaging;Race;Radiation;radiation response;Radiation Therapy Oncology Group;Randomized;Recurrence;Salvage Therapy;side effect;Stains;Standardization;Stromal Cells;Subgroup;Surgical margins;System;telomere;Testing;Time;Tissue Microarray;tool;treatment effect;treatment response;tumor;tumor behavior;unnecessary treatment;Urology;Validation;Weight

PROJECT_TITLE: The telomere biomarker as a tool to inform decision-making for aggressive salvage therapy in men with rising PSA post prostatectomy

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]