ED_INST_TYPE: COMPUTER CENTER

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Public Health Relevance Statement: The Infrastructure Component (IC) of the HuBMAP Integration, Visualization & Engagement  (HIVE) Collaboratory will provide the open data platform for study of multi-scale tissue  organization and function through 3D biomolecular tissue maps in the spatial framework of the  human body. The studies enabled on this platform will facilitate comparisons across individuals,  organs, tissues, and cells to characterize normal function and variation, leading to deeper  understanding of underlying mechanisms of variation or disease, and ultimately pointing to  interventions for disease prevention or treatment.

PI_NAMEs: BLOOD, PHILIP D. (contact);SILVERSTEIN, JONATHAN C.

PROGRAM_OFFICER_NAME: CONROY, RICHARD

PROJECT_TERMS: 3-Dimensional;Anatomy;Architecture;Area;Atlases;Automation;Biological Assay;Cells;Cloud Computing;Collaborations;collaboratory;Communities;community engagement;community partners;computerized data processing;Data;data ingestion;data pipeline;data platform;Data Set;data standards;data visualization;Development;Disease;disorder prevention;Documentation;Ensure;flexibility;Friction;Histologic;Human;Human BioMolecular Atlas Program;Human body;Human Resources;human tissue;Hybrids;Individual;Infrastructure;Ingestion;International;interoperability;Intervention;Joints;knowledge graph;Leadership;Maps;Measurement;member;Modeling;Molecular;multimodality;Ontology;open data;Organ;Phase;Production;Provider;public health relevance;Research;Resolution;Resources;Services;Supercomputing;tissue mapping;Tissues;tool;Translating;Universities;Variant;Vision;Visualization

PROJECT_TITLE: Flexible Hybrid Cloud Infrastructure for Seamless Integration and Use of Human Biomolecular Data and Reference Maps [1 of 5]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The goal of this proposal is to elucidate the effect of unhealthy food and beverage marketing as a key environmental determinant that places Black young adults at increased risk for nutritional disparities and nutrition-related chronic diseases, including type 2 diabetes, hypertension, and some cancers. The proposed research will evaluate the extent to which exposure to virtual reality (VR)-based food marketing influences biological signals (i.e., electrodermal activity and salivation) and purchase intention following a lab-based randomized experiment in a sample of Black and white young adults. Findings can inform novel behavioral interventions and current regulatory efforts, such as the Federal Trade Commission’s initiative to reduce stealth digital food marketing targeting vulnerable groups.

PI_NAMEs: CASSIDY, OMNI  (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;Adolescent;Advertisements;Affect;Arousal;Award;Awareness;behavior measurement;Behavior Therapy;Behavioral;behavioral outcome;Beverages;Biological;Black race;Bypass;Child;Chronic Disease;Communities;community advisory board;community based participatory research;Competence;Conscious;Consumption;cue reactivity;Data;design;Development;Diet;digital;digital platform;digital technology;Disease;disorder risk;Disparity;Economic Conditions;Environment;Equity;Ethnic Origin;excessive weight gain;experience;experimental study;Exposure to;Food;food consumption;food marketing;food security;Future;Goals;Health;Household;Hunger;Hypertension;Income;Individual;Inequity;infancy;Intake;Intention;Link;Malignant Neoplasms;Marketing;Measurement;medical schools;Mentors;Mentorship;Mission;Modeling;Monitor;Motivation;National Institute on Minority Health and Health Disparities;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional;Nutritional Support;Outcome;Paper;Patient Self-Report;Persons;Policies;Positioning Attribute;prevent;Price;Proxy;Publishing;Race;Randomized;Reporting;Research;Research Personnel;Risk;Role;Saliva;saliva secretion;Salivary;Sampling;Scientist;Signal Transduction;skills;social media;Socioeconomic Status;socioeconomics;Statistical Data Interpretation;Structural Racism;Techniques;Technology;Television;theories;Training;transition to adulthood;Unhealthy Diet;United States Federal Trade Commission;virtual reality;Vulnerable Populations;Weight;Work;young adult;Youth

PROJECT_TITLE: The effect of virtual reality-based food marketing on biological hunger signals and purchase intention in young adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Adaptive evolution (AE) is the driving force behind the emergence of antibiotic resistance and if it were possible to predict AE before it happens, it could help in preventing resistance. Here we use cutting-edge existing and newly designed genomics tools and analytical approaches to develop a machine learning model that can predict AE a priori, and on a genome-wide scale.

PI_NAMEs: ORTIZ-MARQUEZ, JUAN CESAR FEDERICO;VAN OPIJNEN, TIM  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Achievement;Affect;Antibiotic Resistance;Antibiotics;Architecture;Automobile Driving;Bacteria;Binding Sites;Biological;Biological Process;Biomass;Biomedical Engineering;ChIP-seq;Chromosome Mapping;Communicable Diseases;Complex;Data;design;Development;DNA Binding;driving force;droplet sequencing;Drug resistance;emerging antibiotic resistance;emerging antimicrobial resistance;Ensure;Environment;Escherichia coli;Event;Evolution;experience;experimental study;Exposure to;Fermentation;Frustration;Genes;Genetic;genetic architecture;Genetic Epistasis;Genetic Transcription;Genome;genome-wide;genomic tools;Genomics;Goals;Immune system;Immunotherapeutic agent;Industry;Life;Link;Machine Learning;machine learning model;machine learning prediction;Malignant Neoplasms;Maps;Microfluidics;Modeling;Mutation;network architecture;novel;Organism;Outcome;overexpression;pathogenic bacteria;Pathway Analysis;Pattern;Phenotype;Photosynthesis;Planet Earth;predictive modeling;prevent;Process;process optimization;programs;Repression;Resistance;response;Shapes;Streptococcus pneumoniae;Stress;System;Testing;Time;tool;Training;trait;transcription factor;transcription regulatory network;transcriptome;transcriptome sequencing;transposon sequencing;Yeasts

PROJECT_TITLE: A priori adaptive evolution predictions for antibiotic resistance through genome-wide network analyses and machine learning

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Shift-and-persist coping shows promise as an effective intervention strategy to mitigate the early signs of chronic disease stemming from socioeconomic disadvantage and cultural stress (i.e., contextual stressors) among racial/ethnic minority adolescents. To inform the design of a shift-and-persist intervention targeting minoritized youth, it is crucial to uncover what promotes shift-and-persist coping as well as its protective utility against the broader range of co-occurring socioeconomic and cultural stressors. Findings from this project have important implications for public health by identifying socioecological factors that strengthen shift-and-persist coping across adolescence, elucidating how the health effects of configurations of contextual stress may vary by distinct trajectories of shift-and-persist coping across adolescence, and providing preliminary evidence of intervention modalities that can enhance this coping mechanism among youth populations vulnerable to chronic illnesses.

PI_NAMEs: COULTER, KIERA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Adult;allostatic load;Applied Skills;apprenticeship;Area;Behavioral;behavioral health;Biological;biological adaptation to stress;Biological Markers;biopsychosocial;Blood Pressure;Buffers;burden of chronic illness;career;Censuses;Chronic;Chronic Disease;Competence;coping;coping mechanism;Coping Skills;Data;Data Analyses;Data Collection;Data Set;design;Development;digital;Disease;Disease Progression;disorder risk;Ecology;economic disparity;Education;effective intervention;eighth grade;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;evidence base;Exposure to;Family;Feasibility Studies;Fostering;Goals;Growth;Health;health outcome disparity;improved;Inflammation;innovation;Interleukin-6;Intervention;Investigation;Knowledge;Knowledge acquisition;Life;Life Cycle Stages;Link;low socioeconomic status;Measures;Mental Depression;Mental Health;Mentorship;minority children;minority communities;minority stress;Modality;Modeling;National Institute on Minority Health and Health Disparities;neighborhood disadvantage;novel;optimism;Outcome;Pathway interactions;Pattern;peer;physical conditioning;Physiological;Population;Positioning Attribute;positive youth development;preempt;prevent;Process;programs;promote resilience;psychologic;Public Health;Race;racial discrimination;racial disparity;racial diversity;racial health disparity;racial minority;Reduce health disparities;Reporting;Research;Research Personnel;resilience;Sampling;Scholarship;Schools;Shapes;Signal Transduction;skills;Skin;socioeconomic disadvantage;socioeconomics;stem;Sterile coverings;Stress;stressor;substance use;System;therapy design;Time;Training;transition to adulthood;Translating;Typology;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Promoting Resilience and Reducing Health Disparities: Towards a Shift-and-Persist Intervention


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Human cell division is regulated at the G1/S transition before DNA is replicated. The primary drivers of cells  through the G1/S transition are the cyclin-dependent kinases Cdk4 and Cdk6 in complex with D-type cyclins.  The goal of this project is to determine the mechanisms that Cyclin D-Cdk4/6 complexes use to drive cell  division, to identify the targets of Cyclin D-Cdk4/6 kinases in cells, and to discover small molecules that inhibit  Cyclin D’s ability to target substrates for phosphorylation by Cdk4/6.

PI_NAMEs: SKOTHEIM, JAN M (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Alanine;Alleles;alpha helix;analog;Binding;Biochemistry;Biological Assay;Biological Sciences;C-terminal;Cancer Control;Cancer Model;cancer therapy;Cell Cycle Arrest;Cell division;Cell Line;Cell Proliferation;Cells;chemical genetics;Clinical Trials;Complex;Cyclin D1;Cyclin-Dependent Kinases;Cyclins;Data;delivery vehicle;design;DNA;Docking;Enzymes;experimental study;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;G1/S Transition;genetic approach;Goals;Human;improved;In Vitro;in vitro testing;in vivo;inhibitor;Knowledge;Libraries;Location;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Molecular;molecular imaging;mouse model;Mus;Mutation;Neuroblastoma;Peptides;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Property;Proteomics;Reagent;Regulation;Retinoblastoma Protein;Role;Site;small molecule;small molecule libraries;structural biology;Structure;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapeutic target;tool;tumor;tumor growth;Xenograft procedure

PROJECT_TITLE: Project 1: Determine the mechanisms Cyclin D-Cdk4/6 uses to drive cell proliferation


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Many older adults with and without hearing loss struggle with understanding speech in the presence of other talkers. Noninvasive brain stimulation has shown promise for improving intelligibility in noise, but benefits in older adults who struggle most, and additional benefits beyond those obtained from behavioral auditory training have not been evaluated. This work tests a method of noninvasive brain stimulation in older adults struggling with speech mixtures to determine if it can increase benefits from auditory training.

PI_NAMEs: ROVERUD, ELIN  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Address;Adult;Affect;Auditory;Auditory system;aural rehabilitation;Behavioral;brain tissue;Cephalic;Cognitive;cognitive benefits;cognitive training;Communication;Communication difficulty;Complex Mixtures;Comprehension;Computers;Development;Enrollment;Environment;experience;Goals;Grant;Hearing Aids;hearing impairment;Home;Impairment;improved;Individual;Investigation;Laboratories;Measures;Methods;motor learning;National Institute on Deafness and Other Communication Disorders;new technology;Noise;noninvasive brain stimulation;normal hearing;older adult;Participant;participant enrollment;Performance;Peripheral;placebo group;Presbycusis;programs;Questionnaires;Randomized;Recommendation;recruit;Reporting;Research;Scalp structure;screening;Sensorineural Hearing Loss;Speech;speech in noise;Speech Intelligibility;speech recognition;Strategic Planning;Testing;Training;Training Programs;Visit;Work

PROJECT_TITLE: Transcranial stimulation combined with auditory training

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative This proposal requests support for the Ion Channels Gordon Research Conference and Seminar (GRC/GRS), a meeting in which detailed presentations of the latest, state-of-the-art research on ion channels will be curated, and attendees will pursue detailed discussions and define questions of biomedical importance. Ion channels are important proteins that govern the electrical excitability of nerve, muscle, and endocrine cells, and their dysfunction leads to diseases that include epilepsy, paralysis, cardiac arrhythmia, and diabetes, making them targets for effective drug therapies. Ultimately, the discussions and research collaborations resulting from the Ion Channels GRC/GRS will pave the way for innovative approaches to treat various human diseases.

PI_NAMEs: CHANDA, BARON  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Academia;Address;Area;Arrhythmia;Big Data;Binding;Biological;biological research;Biology;Biomedical Research;Brain;Calcium Signaling;career;career development;Catalysis;Cells;Collaborations;college;Communities;Complex;Comprehension;Creativeness;Data;Diabetes Mellitus;Disabled Persons;Disease;diversity and inclusion;drug action;drug discovery;Endocrine;Epilepsy;Fees;Fostering;Foundations;Functional disorder;Goals;graduate student;Health;Hour;Human;Human Biology;human disease;Industry;innovation;insight;International;Ion Channel;Ion Channel Gating;Ion Transport;Knowledge;Ligands;Lipids;Location;Machine Learning;Massachusetts;meetings;Membrane;Methods;Mission;Modality;Modeling;Molecular;Molecular Structure;Muscle;National Institute of Neurological Disorders and Stroke;Nature;Nerve;Nervous System;Nervous System Disorder;novel therapeutics;Organ;painful neuropathy;Paralysed;Participant;peer;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Postdoctoral Fellow;posters;programs;Proteins;Regulation;Reproducibility;Request for Proposals;Research;Research Personnel;Role;Scientific Advances and Accomplishments;Scientist;Sensory;Series;Shapes;Signal Transduction;Sorting;structural biology;Structure;success;symposium;System;Taste Perception;therapeutic target;Time;Tissues;Touch sensation;translocase;Travel;Underrepresented Minority;United States National Institutes of Health;voltage;Woman;Work;Workplace

PROJECT_TITLE: 2024 Ion Channels Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (45)]


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ACCRA

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: YEMAACHI BIOTECH

PI_NAMEs: BEDIAKO, YAW  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Africa;African;African ancestry;anti-cancer research;Area;Benchmarking;biobank;Bioinformatics;Biological;Biological Factors;Biopsy Specimen;Biotechnology;black patient;cancer genome;cancer health disparity;Characteristics;Chromosome Mapping;clinically relevant;cloud based;cohort;Collaborations;college;Complex;computer framework;Data;Data Element;data repository;Databases;Dedications;early onset;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;Equity;experimental study;Feedback;Flow Cytometry;Genes;Genetic;Genetic study;Genetic Variation;Genome;genome analysis;genome sequencing;Genomics;Geography;Germ Lines;Germ-Line Mutation;Human Genome;human pangenome;human reference genome;Immune;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inequity;innovation;Intervention;Link;Lived experience;London;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methodology;Methods;Molecular;nanopore;novel;outcome disparities;pan-genome;Participant;Patient advocacy;Patient Self-Report;Patients;Persons;Phenotype;Plasma;Policies;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;Protocols documentation;racism;recruit;reference genome;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;sequencing platform;Shotguns;single molecule;Site;social;social determinants;Standardization;study population;Surveys;sustainability framework;Technology;tool;transcriptome sequencing;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;United Kingdom;United States;Variant;Vertebral column;virtual;whole genome;Work;working group

PROJECT_TITLE: SAMBAI - Yemaachi Biotech


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our new polymer devices enable safe, affordable, effective, and convenient therapy of neovascular eye diseases such as neovascular age-related macular degeneration and proliferative diabetic retinopathy, which cause irreversible blindness in millions of patients. Therefore, this research is consistent with the mission of the NIH, which pertains to developing resources that will assure the nation's capability to efficiently prevent and/or treat human diseases.

PI_NAMEs: CORSON, TIMOTHY W;YEO, YOON  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acids;angiogenesis;Angiogenesis Inhibitors;Animal Model;anti-fungal agents;Apoptosis;Biological Factors;Biological Products;biomaterial compatibility;biophysical properties;Blindness;Cannulas;cell growth;Cell model;Cell Proliferation;Choroid;Choroidal Neovascularization;Clinical;clinically relevant;Complement;cost;Custom;Data;Development;Devices;Disease;Disease Progression;Drug Delivery Systems;Drug Kinetics;Drug Stability;effective therapy;Encapsulated;Endothelial Cells;Ensure;Enzymes;experimental study;Exudative age-related macular degeneration;Eye;Eye diseases;ferrochelatase;Formulation;Frequencies;Gene Modified;Glycolates;Goals;Griseofulvin;Healthcare Systems;Heme;Human;human disease;Implant;In Vitro;in vivo;inhibitor;Injections;innovation;intravitreal injection;Iron;Kinetics;knock-down;Lasers;Lead;life span;Local Therapy;melting;Methods;migration;Mission;Modality;Modeling;mouse model;Mus;Mutation;neovascular;neovascularization;novel;novel therapeutics;ocular neovascularization;Oryctolagus cuniculus;Oxygen;particle;Patients;Pharmaceutical Preparations;polycaprolactone;Polymers;prevent;proliferative diabetic retinopathy;protoporphyrin IX;Public Health;Research;Research Support;Resources;Retina;Retinal Diseases;Retinal Neovascularization;side effect;Signal Transduction;small molecule;Specificity;stem;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;therapy resistant;Toxic effect;Toxicity Tests;Tube;United States National Institutes of Health;Vascular Endothelial Growth Factors;Visual impairment

PROJECT_TITLE: Long-acting formulations of griseofulvin for ocular neovascularization therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: PROJECT NARRATIVE Molar Hypomineralization (MH) is a prevalent enamel defect affecting 15% of children worldwide; it manifests on the enamel surface as soft and porous demarcated opacities with reduced restorative success and is highly associated with hypersensitivity caused by pulpal inflammation. This project aims to investigate the unknown mechanisms underlying pulpitis development in MH by studying the effects of repetitive noxious stimulus and bacterial infection on dental pulp inflammation in hypomineralized teeth and the effect of enamel remineralization to prevent bacterial infection. The results of this project will shed light on the pathomechanisms of pulpitis in MH to facilitate targeted diagnosis and improved treatment plans, ultimately reducing the global burden of pulpitis in MH and the general population.

PI_NAMEs: KARAASLAN, HAKAN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Affect;Afferent Neurons;Animals;Anti-Bacterial Agents;Bacteria;Bacterial Infections;Biology;Career Choice;career development;Cells;Characteristics;Child;Chronic;Clinical Research;Complex;Confocal Microscopy;cytokine;Data;deciduous tooth;Defect;density;Dental;Dental caries;Dental Enamel;Dental Hygiene;Dental Pulp;Dentin;Dentin Formation;Development;Diagnosis;Diamines;Economic Burden;Etiology;evidence base;Fellowship;Flow Cytometry;Fluorides;Funding;General Population;Goals;Growth;Hypersensitivity;Image;Immune;Immune response;Immunofluorescence Immunologic;Immunology;improved;in vivo;Incisor;Inflammation;Inflammatory Response;Innate Immune Response;Interdisciplinary Study;K-Series Research Career Programs;Knockout Mice;Lesion;Liquid substance;Mentors;Mentorship;Microbial Biofilms;Microbiology;microCT;mineralization;Minerals;Modeling;Molar tooth;mouse model;Movement;multidisciplinary;Mus;National Institute of Dental and Craniofacial Research;Neurons;Operating Rooms;Oral;Organ;Pain;Patients;permanent tooth;Phenotype;porcine model;Porosity;Postdoctoral Fellow;prevent;Preventive;Primary Dentition;Proteins;Pulpitis;Quality of life;Regimen;remineralization;Research;Research Personnel;Research Project Grants;Research Training;Resolution;response;Role;Scientist;Sensory;Silver;Spatial Distribution;Spottings;Stimulus;Structure;success;Surface;targeted treatment;Testing;Therapeutic;Tissues;Tooth Demineralization;Tooth structure;Training;translational approach;translational study;transmission process;treatment planning;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: Neuronal and Bacterial Driven Inflammation of the Dental Pulp in Molar Hypomineralization

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Recovery Support Services;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: MARYLAND TREATMENT CENTERS, INC.

ORG_STATE: MD

PHR: Project Narrative Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD). The multicomponent Youth Opioid Recovery Support (YORS) intervention for young adults seeks to increase adherence to extended-release MOUD and reduce opioid relapse through family involvement, assertive outreach, low-barrier access to MOUD, and contingency management. By expanding investigations of the evidence based YORS intervention to adolescents, Spanish speaking families, and adolescents on sublingual buprenorphine, this project will significantly contribute to our knowledge base of practical strategies to address the opioid crisis in youth.

PI_NAMEs: FISHMAN, MARC ;WENZEL, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: 18 year old;access disparities;addiction;Address;Adherence;Adolescence;Adolescent;Adult;Age;arm;Assertiveness;Buprenorphine;Caring;Cessation of life;Childhood;Clinical;clinical care;clinical infrastructure;Clinical Trials;Communities;contingency management;Country;Data Set;design;Development;Diagnosis;Disease Management;disparity reduction;Dose;evidence base;experience;Family;Family member;Fatality rate;Feasibility Studies;feasibility testing;Fentanyl;Future;Gun injury;health disparity;heroin use;Hispanic;Home;improved outcome;Incentives;innovation;Inpatients;insight;Intervention;Interview;Investigation;Knowledge;knowledge base;Latino;life span;Linguistics;Medicaid;medication compliance;medication for opioid use disorder;misuse of prescription only drugs;mortality;Naltrexone;Not Hispanic or Latino;Opioid;opioid epidemic;opioid overdose;Outpatients;outreach;Overdose;overdose death;Percocet;Persuasive Communication;Pharmaceutical Preparations;pill;Population;Preparation;Randomized, Controlled Trials;Recovery Support;Reinforcement Schedule;Relapse;Reporting;Research Infrastructure;Smoke;Spanish;standard of care;Target Populations;Techniques;Testing;Training;Translating;treatment as usual;treatment duration;trend;Underserved Population;United States;uptake;Vehicle crash;young adult;Youth

PROJECT_TITLE: Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD adherence to adolescents with OUD

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-E (O1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A cell must know what genes to transcribe and where to send these messages in order to carry out specific cellular functions. This proposal uses an emerging model system, Stentor coeruleus, a giant single cell with a clear axis and spatial complexity comparable to an animal embryo to understand how RNA and genome regionalization contribute to cellular patterning and function. This work will further our understanding of how cells form patterns and enable us to study what happens when patterns are broken in development and disease.

PI_NAMEs: ALBRIGHT, ASHLEY R (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Alzheimer's Disease;Animals;Anterior;Architecture;Biological Models;Biology;Brain;Cell Compartmentation;Cell model;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;cellular imaging;Cellular Morphology;Cellular Structures;Chromatin;Chromatin Structure;Chromosome Mapping;Complex;Cytoskeleton;Data;Deposition;Destinations;Development;Disease;Elements;Embryo;Exhibits;Foundations;fungus;Gene Expression;Gene Structure;Genes;Genetic Transcription;Genome;genome sequencing;Genomics;Giant Cells;Goals;Human;Image;Individual;innovation;knock-down;Length;lens;Location;Macronucleus;Mediating;Mental Depression;Microsurgery;Microtubule Bundle;Microtubules;model organism;Modernization;Molecular;Molecular Biology;Motor;Natural regeneration;Neurons;Nuclear;Oral cavity;Organelles;Organism;Pattern;Plants;Play;Polyploidy;Positioning Attribute;programs;Property;Protein Biosynthesis;regeneration potential;Regenerative capacity;Regulation;Research;RNA;RNA analysis;RNA Interference;RNA Transport;Role;Running;Shapes;Stereotyping;Stretching;Structure;Synapses;System;Tail;tool development;trafficking;Training;Transcript;transcriptome sequencing;transcriptomics;Travel;Tubulin;whole genome;Work;wound healing

PROJECT_TITLE: RNA and genome regionalization in giant single cells: implications for cellular patterning

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (MK)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative There is no early detection for Sjögren’s Disease (SjD) and its precursor autoimmune AI-Sicca. We have developed an electrochemical assay, EFIRM, that can measure the diagnostic autoantibodies of SjD, SSA/Ro52 and SSB/La. We hypothesize that IgA to these autoantibodies, can early detect and predict AI-Sicca from SjD.

PI_NAMEs: CHIA, DAVID S.;SCOFIELD, ROBERT HAL;WONG, DAVID T (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Abbreviations;Address;Affect;age related;Atrophic;Autoantibodies;Autoimmune;Autoimmune Diseases;B-Cell Lymphomas;Basic Science;Biological Assay;Biological Markers;Biopsy;Blinded;Blood;Caring;chronic autoimmune disease;Classification;Clinical;cohort;Complex;Constitutional Symptom;Control Groups;Data;Data Analyses;Detection;Diagnosis;Diagnostic;Disease;Drug Side Effects;Dryness;Early Diagnosis;electric field;Enzyme-Linked Immunosorbent Assay;Exocrine Glands;eye dryness;Fibromyalgia;Foundations;Glomerulonephritis;Goals;head and neck cancer patient;IgA1;Immunoassay;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;improved;Inflammation;innovation;Lacrimal gland structure;Linear Regressions;Lymphocyte;Lymphoma;Measurement;Measures;Mediation;Medical;Medical Research;Menopause;Modeling;Monitor;monomer;mortality;Multi-site clinical study;National Institute of Dental and Craniofacial Research;Oklahoma;older adult;Oral;Oral cavity;Pathologic;Patients;Pharmaceutical Preparations;Physiological;Polymers;Prevalence;prospective;Prospective cohort;Quality of life;Radiation;Randomized;Research;Risk Assessment;Saliva;Salivary;salivary assay;Salivary Gland Tissue;Salivary Glands;Salivary immunoglobulin A;Sampling;screening;Serology test;Serum;Sjogren's Syndrome;Statistical Data Interpretation;symptom treatment;Symptoms;Testing;Time;United States National Institutes of Health;Validation;Vasculitis;Xerostomia

PROJECT_TITLE: Saliva Anti-SSA/Ro and Anti-SSB/La for Early Detection of Sjögren’s and SICCA Syndromes

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN

PROJECT_TERMS: Advisory Committees;American Association for the Advancement of Science;Bioinformatics;Biomedical Research;career;Collaborations;Communities;Critiques;Delaware;Development;Disease;Economics;Education;Educational workshop;effectiveness evaluation;Evaluation;experience;Faculty;Funding;Future;Goals;graduate student;Grant;Heart;Human Resources;Impact evaluation;improved outcome;Institution;Leadership;meeting abstracts;Mentors;Mission;Occupations;Pilot Projects;Policies;Principal Investigator;Procedures;Process;Program Development;Program Evaluation;Program Research Project Grants;programs;Publications;Recommendation;Research;Research Activity;research and development;Research Personnel;Resource Sharing;Resources;Services;Strategic Planning;Students;success;symposium;undergraduate student

PROJECT_TITLE: Delaware INBRE


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: BOISE

ORG_NAME: IDAHO HOSPITAL ASSOCIATION

ORG_STATE: ID

PI_NAMEs: JOHNSON, CHRISTOPHER  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Topical Microbicides;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: GAITHERSBURG

ORG_NAME: QUALITY BIOLOGICAL, INC.

PI_NAMEs: FREMONT, VALERIE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS Vaccines;Biological Assay;Clinical;Cloning;Contractor;Contracts;cytokine;Development;Equipment and supply inventories;Funding;Genetic;HIV vaccine;Local Microbicides;Maintenance;Mission;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;Nongovernmental Organizations;novel;Peptides;polyclonal antibody;pre-clinical;programs;quality assurance;Quality Control;Reagent;reagent testing;Research Personnel;Research Priority;Resources;Services;United States National Institutes of Health;Vaccine Adjuvant;vaccine development;vaccine immunogenicity;Vaccine Research;vaccine safety;vector vaccine;Viral Proteins;Virus

PROJECT_TITLE: Reagent Resource Support Program for AIDS Vaccine Development


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: RHODES, CAROL  (contact)

PROJECT_TERMS: catalyst;Cells;Contractor;Data;database of Genotypes and Phenotypes;Databases;Development;Disease;DNA Methylation;functional genomics;Funding;genome sequencing;genomic data;Goals;Heart;Hematological Disease;Lung;Multiomic Data;National Heart, Lung, and Blood Institute;Phase;precision medicine;Process;programs;Research Personnel;Resolution;Resources;Sleep Disorders;Trans-Omics for Precision Medicine;whole genome

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - DNA METHYLATION


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Heart Disease;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is growing evidence that maternal health and behaviors in pregnancy, such as pre-pregnancy obesity, excessive gestational weight gain, poor diet, smoking, and adverse pregnancy outcomes, are linked to fetal programming for obesity and cardiovascular disease (CVD) risk in the offspring. Yet, there is a surprising lack of research on the role of prenatal sedentary behavior, physical activity, and sleep (conceptualized together as 24-hour behavior) on offspring obesity risk and CVD risk; this is an unfortunate research gap since there is strong physiological rationale that these behaviors in pregnancy could influence offspring health and are modifiable intervention targets in pregnancy. This multi-site observational cohort study will leverage state-of- the-art, 24-hour behavior assessment in each trimester of pregnancy, collected as part of the ongoing Pregnancy 24/7 cohort study and add additional assessments of offspring growth, adiposity, and CVD risk through 24 months to inform future primordial prevention interventions to decrease the risk of offspring obesity and CVD across the lifespan.

PI_NAMEs: BARONE GIBBS, BETHANY ;WHITAKER, KARA MARIE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;adverse pregnancy outcome;Aging;Behavior;Behavior assessment;Birth;Blood Pressure;Blood Vessels;Body mass index;Breast Feeding;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Child;Child Health;Childhood;clinically relevant;Cohort Studies;Data;Data Analyses;Development;Diet;Disease;early childhood;early onset;Enrollment;Epidemic;Fetal Growth;fetal programming;First Pregnancy Trimester;Future;gestational weight gain;Goals;Growth;Health;Home environment;Hour;Hypertension;in utero;Incidence;interest;Intervention;late life;Late pregnancy;life span;Link;Maternal Behavior;Maternal Exposure;Maternal Health;Measurement;Measures;Medical Records;Methods;Modeling;modifiable behavior;Monitor;National Heart, Lung, and Blood Institute;novel;Obesity;obesity in children;obesity risk;observational cohort study;offspring;offspring obesity;Outcome;Participant;Pattern;Persons;Physical activity;Physiologic pulse;Physiological;poor sleep;post pregnancy;postnatal;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;prenatal exposure;prepregnancy obesity;prevent;Prevention;preventive intervention;primary outcome;Primary Prevention;prospective;Questionnaires;Research;response;Risk;Risk Factors;Risk Reduction;Role;sedentary lifestyle;Site;Sleep;Smoking;Statistical Methods;theories;Time;Unhealthy Diet;United States;vigorous intensity;Visit;Woman

PROJECT_TITLE: Sedentary behavior, physical activity, and 24-hour behavior in pregnancy and offspring health: the Pregnancy 24/7 Offspring Study

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative We discovered a previously unrecognized mechanism by which neurons protect against effects of protein aggregation—they physically throw out their threatening trash in membrane-surrounded large vesicles (exophers) for uptake by remote cells. “Exopher-genesis” is increased when neurons are subjected to proteostasis challenges, including expression of human Alzheimer's disease fragment A 1-42. Since we propose that exopher-genesis is a conserved pathway for maintaining neuronal health and we speculate that older age dysfunction of the exopher pathway might contribute to neurodegeneration and spread of neurotoxic species, dissection of the exopher mechanism should provide novel insight on Alzheimer's disease-relevant pathology that might be manipulated for therapeutic benefit.

PI_NAMEs: DRISCOLL, MONICA A. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: ABI2 gene;Address;Adult;Affect;Age;age effect;age related decline;Aging;aging brain;aging population;Alzheimer's Disease;Animal Model;Animals;Area;Autophagocytosis;Basic Science;Biological Models;Biology;Brain;Caenorhabditis elegans;Cell Maintenance;Cells;Cellular biology;Chronology;clinical development;Data;Disease;Dissection;Distant;Elderly;Elements;extracellular;Functional disorder;Genes;Genetic;genetic manipulation;genome wide association study;Goals;Health;healthy aging;Homologous Gene;Human;human disease;human old age (65+);Human Pathology;Impairment;in vivo;Individual;insight;Intervention;knock-down;Label;Life;life span;Longevity;longevity gene;Maintenance;Mammals;Membrane;Microscope;middle age;misfolded protein;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;multicatalytic endopeptidase complex;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuronal cell body;Neuronal Dysfunction;Neurons;neuroprotection;neurotoxic;novel;Orthologous Gene;Outcome;overexpression;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Physiological;Play;polyglutamine;Population;Process;Production;protein aggregation;Protein Biosynthesis;protein folding;Proteins;proteostasis;proteotoxicity;Publishing;Quality Control;response;RNA Interference;Role;Route;screening;segregation;Stress;Structure;System;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;Transgenes;uptake;Vesicle;Visualization;Work

PROJECT_TITLE: Defining roles of genetic and age in extracellular elimination of neurotoxic aggregates


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE Much mental health research relies on measurements of brain activity across different parts of the brain, and often poses difficult problems in statistical analysis. The research supported by this grant develops new methods of analyzing brain signals as they evolve across time. Of special interest is the way networks of interacting brain components may change under varying conditions.

PI_NAMEs: KASS, ROBERT E (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Acceleration;Applications Grants;Area;Attention;Behavior;behavior measurement;Behavioral;Biophysics;Brain;brain based;Brain region;Collaborations;Collection;Communication;Coupling;Data;deep neural network;design;Development;Dimensions;Disease;effectiveness evaluation;Electrodes;Event;Evolution;Frequencies;Functional disorder;Goals;Grant;Graph;Group Structure;high dimensionality;improved;Individual;Information Networks;insight;interest;Investigation;Lead;Letters;Measurement;Measures;Mental Health;Methods;Modeling;Movement;network dysfunction;neural;neural model;neural network;Neural Network Simulation;neuromechanism;Neurons;neurophysiology;neurotransmission;Noise;novel strategies;novel therapeutics;Patients;Phase;Physiological;Process;programs;Psychopathology;Reaction Time;Research;Research Support;Role;screening;Series;Signal Transduction;simulation;Source;spatiotemporal;Specific qualifier value;Statistical Data Interpretation;Statistical Models;statistics;Stochastic Processes;Structure;Synaptic Transmission;Techniques;Technology;Time;Time Series Analysis;tool;Training;vector;Weight;Work

PROJECT_TITLE: Analysis of Nonstationary Point Process Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Kidney Disease;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: Project Narrative The objective of this Katz R01 project is to develop a novel multi-scale computational model to: 1) quantify the local and systemic hemodynamics (i.e., pressure, flow rate, shear stress, oxygen transport, etc.) during phases of active hemorrhage, aortic occlusion with REBOA, and resuscitation, 2) identify vascular regions that are vulnerable to ischemic damage as a result of the altered hemodynamics, 3) predict key physiologic responses related to vascular compliance, oxygen delivery and renal autoregulation during hemorrhage and aortic occlusion, and 4) determine optimal aortic occlusion size and duration of partial vs. full REBOA strategies to prevent ischemia-reperfusion injuries and renal failure. At its core, this proposal builds on the PI’s training in cardiovascular fluid mechanics, trauma and shock, but represents an important new direction that has the potential to transform the field of hemorrhagic shock research.

PI_NAMEs: RAHBAR, ELAHEH  (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Address;Adopted;Animal Experimentation;Animal Model;Animals;Aorta;Balloon Occlusion;Baroreflex;Behavior;Biological;Biological Markers;Blood flow;Blood Vessels;Blood Volume;Cardiac Output;Cardiovascular system;Catheters;Cessation of life;Chest;Clinical;computer framework;Computer Models;Computer software;computerized tools;Coupled;design;Development;Devices;Distal;Engineering;Environment;Evaluation;Family suidae;Feedback;Growth;hemodynamics;Hemorrhage;Hemorrhagic Shock;Homeostasis;improved;in silico;in vivo;indexing;Injury;innovation;Institution;Intervention;Ischemia;Kidney;Kidney Failure;Knowledge;Liquid substance;Mechanics;Methods;Military Personnel;minimally invasive;Modeling;multi-scale modeling;multidisciplinary;next generation;novel;open source;Oxygen;oxygen transport;Performance;Perfusion;Phase;Physicians;Physiological;porcine model;Pre-Clinical Model;Preclinical Testing;pressure;prevent;preventable death;Renal function;Reperfusion Injury;Reperfusion Therapy;Research;response;Resuscitation;Risk;risk mitigation;Scientist;shear stress;Shock;simulation environment;Stents;Sum;Techniques;Testing;Time;tool;Training;Trauma;Traumatic injury;Validation;Vena Cava Filters;Venous;Work

PROJECT_TITLE: Development of a multi-scale closed loop model for hemorrhagic shock: a platform to assess REBOA performance

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: PHILADELPHIA

ORG_NAME: NATIONAL DISEASE RESEARCH INTERCHANGE

PHR: Program Director/Principal Investigator (Bell, Thomas, J): Project Narrative The research demand for human tissues continues to grow and the HTORR program provides a unique service to biomedical investigators nationwide whose research requires human tissues, organs and well annotated data. Over the past 4 years, nearly 500 scientific papers were published by scientists who used HTORR-provided tissues, confirming HTORR's indispensable contribution to the biomedical research community and the impact of these services on the search for new treatments and cures for common and rare diseases, including HIV/AIDS. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BELL, THOMAS J (contact)

PROGRAM_OFFICER_NAME: MURPHY, STEPHANIE

PROJECT_TERMS: Administrative Supplement;Award;Awareness;Biomedical Research;Body System;Communication;Communities;Custom;Data;Databases;Development;Disease;Donor Selection;Elements;empowerment;Ensure;Funding;Grant;HIV/AIDS;Human;human disease;Human Resources;human tissue;Improve Access;improved;Industry;Infrastructure;innovation;Methodology;Methods;Mission;Modeling;Modification;Normal Range;Organ;outreach;Paper;Principal Investigator;Process;programs;prospective;Protocols documentation;Publishing;Rare Diseases;Recovery;Research;Research Personnel;Resources;Sampling;Scientist;Services;Shipping;Site;Source;Time;tissue resource;Tissues;Training;United States National Institutes of Health

PROJECT_TITLE: Research Resource for Human Organs and Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Very preterm (VPT) children are 2-4 times more likely than term control (TC) children to be diagnosed with a psychiatric disorder, including anxiety, ADHD, and socioemotional communicative problems. Childhood internalizing symptoms are noted developmental precursors to later psychiatric risk, yet the literature is missing a developmental account of how VPT compared to TC children progress along internalizing trajectories. Our proposed research incorporates a developmental systems approach to examine how internalizing symptoms change over time from birth to age 10, and how neural and environmental factors contribute to these trajectories.

PI_NAMEs: ANAYA, BERENICE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescent;Age;Anxiety;Attention deficit hyperactivity disorder;Birth;Brain;brain behavior;Caregivers;Child;Childhood;Clinical;Development;Diagnosis;Emotional;Environmental Risk Factor;extreme prematurity;Foundations;Individual;infancy;Infant;Infant Health;Intervention;lens;Literature;Longitudinal cohort;maternal stress;Mental disorders;Modeling;neural;Neurophysiology - biologic function;Pathway interactions;Population;Pregnancy;premature;Prevention;Regulation;Reporting;Research;resilience;Risk;risk prediction;Role;social communication;Symptoms;System;Time;Transact

PROJECT_TITLE: The neural foundations of regulation in infancy and the role of individual and environmental factors over time


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nanotechnology;Neurosciences;Pain Research;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Oral cancer pain, the most common and severe form of pain associated with cancer, is ineffectively treated with opioids. The proposed studies aim to investigate how cancer influences the protease-activated receptor 2 (PAR2), a demonstrated mediator of oral cancer pain, to move inside neurons (trafficking) and promote pain signals (signaling). The proposed research training and career development programs will contribute to my long- term goal of directing an academic research laboratory devoted to developing nanomedicines that target trafficking and signaling of PAR2 and similar receptors to provide more effective relief for oral cancer pain.

PI_NAMEs: RAMIREZ GARCIA, PAULINA DANIELA (contact)

PROJECT_TERMS: Address;Afferent Neurons;Analgesics;antagonist;anti-cancer research;asparaginylendopeptidase;Behavior;Cancer Biology;cancer pain;Cancer Patient;cancer site;carcinogenesis;career;career development;Cathepsins;Cell membrane;cell type;Cells;complex biological systems;Confocal Microscopy;Cyclic AMP;Data;design;Development;Drug Delivery Systems;drug development;drug repurposing;Drug Targeting;Endocytosis Induction;Endosomes;Event;Exposure to;Fellowship;Filament;Fostering;Foundations;G-Protein-Coupled Receptors;Gene Modified;Generations;Goals;Golgi Apparatus;Human;Image Analysis;improved;In Vitro;in vivo;in vivo evaluation;innovation;Knowledge;Laboratory Research;Learning;live cell imaging;Location;malignant mouth neoplasm;Malignant Neoplasms;malignant tongue neoplasm;matriptase;Measurable;Measures;Mediating;Mediator;Metalloproteases;Molecular;mouse model;Mus;nanomedicine;nanoparticle;nanoparticle drug;Neurons;neurotransmission;Nociception;non-opioid analgesic;Opioid;Orofacial Pain;overexpression;Pain;Pain management;pain relief;pain signal;PAR-2 Receptor;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Postdoctoral Fellow;Process;Program Development;protease Re;receptor;Receptor Signaling;Regimen;Research;Research Personnel;Research Training;Resolution;response;Role;Sensory;Serine Protease;Signal Induction;Signal Pathway;Signal Transduction;Site;spatiotemporal;ST14 gene;subcellular targeting;Testing;Tissue Banks;trafficking;Training;Translating;Trigeminal System;TRPV1 gene;tumor microenvironment;Visualization;Work

PROJECT_TITLE: Exploring PAR2 Trafficking in Oral Cancer: Implications for Pain Signaling and Drug Delivery


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: Episodic memory declines during healthy aging and is an early symptom of Alzheimer’s disease. The goal of this research is to better understand the nature of subtle memory declines that occur during the preclinical stages of the Alzheimer’s disease continuum, before the emergence of more severe cognitive and clinical symptoms. This information has the potential to impact not only scientific understanding of the aging mind, but also the development of therapeutic strategies targeting aspects of cognitive function that are the most vulnerable to advancing age and Alzheimer’s disease.

PI_NAMEs: HILL, PAUL  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Affect;age difference;aged;aging mind;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Appearance;Behavioral;Behavioral Assay;Biological Markers;Classification;Clinical;Cognitive;cognitive function;cognitive performance;Data;design;Disease Progression;disorder risk;Dissociation;Early Diagnosis;Early Intervention;Elderly;Episodic memory;episodic memory impairment;Event;experience;experimental study;Functional Magnetic Resonance Imaging;Future;Goals;healthy aging;Hippocampus;Human;Impaired cognition;Impairment;Individual;innovation;insight;Location;Longitudinal Studies;Measures;Memory;memory encoding;Memory impairment;Memory Loss;memory process;Methodology;mild cognitive impairment;Modeling;Nature;neglect;Nerve Degeneration;neural;neural correlate;Neuropsychological Tests;Neuropsychology;novel;older adult;Older Population;Outcome;Pathogenesis;Pathologic;Pathologic Processes;pathological aging;Pattern;Performance;Plasma;pre-clinical;Reporting;Research;Resolution;response;Retrieval;Risk Factors;Sampling;Source;Standardization;Subgroup;success;Symptoms;tau Proteins;Testing;therapeutic development;Time;Variant;verbal;Visuospatial

PROJECT_TITLE: Effects of early Alzheimer's pathogenesis on memory accuracy and precision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-A (02)]


NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: FREEDBERG, KENNETH ALAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;antiretroviral therapy;Budgets;Caring;Characteristics;Clinical;clinical care;clinical implementation;Clinical Trials;Computers;cost;cost effectiveness;Country;Data;Developing Countries;Development;Epidemic;experience;Face;Goals;Guidelines;Health;high risk population;HIV;HIV Infections;HIV/AIDS;Human immunodeficiency virus test;improved;Incidence;innovation;insight;Instruction;International;Intervention;Methods;Modeling;Morbidity - disease rate;mortality;Natural History;NIH Office of AIDS Research;novel;Outcome;pandemic disease;Persons;Policies;Policy Maker;Population;prevent;Prevention;preventive intervention;Reduce health disparities;Research;Research Priority;research study;Resource-limited setting;Resources;simulation;skills;Testing;treatment guidelines;treatment response

PROJECT_TITLE: Optimizing HIV Care in Less Developed Countries

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Alcohol-induced blackouts are common and problematic in young adults, but little is known about what causes them beyond the number of drinks consumed. Our recent research suggests that the manner of drinking, in addition to the amount, is important for predicting alcohol-induced blackouts, and wearable alcohol wrist sensors can effectively measure the amount and manner in which alcohol is consumed. The overall goal of the proposed research is to greatly extend our knowledge by using objective transdermal alcohol concentration wrist biosensors to increase our understanding of why alcohol-induced blackouts occur (en bloc and fragmentary) and their relationships with other harmful consequences.

PI_NAMEs: RICHARDS, VERONICA L (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Affect;alcohol consequences;Alcohol consumption;alcohol measurement;Alcoholic Intoxication;Alcohols;Attitude;Behavioral;binge drinking;Biological;Biological Factors;Biological Markers;Biosensor;Blood alcohol level measurement;brief intervention;Cannabis;college;college drinking;Consumption;Data;Data Collection;diaries;drinking;drinking behavior;Event;Expectancy;experience;Family history of;Female;Functional disorder;Goals;Heavy Drinking;high intensity drinking;high risk;high risk drinking;Hippocampus;Hour;Impulsivity;Individual;Informal Social Control;Injury;Interview;Intoxication;Knowledge;Legal;Link;Literature;male;Measurement;Measures;Memory Loss;Methods;Modeling;National Institute of Mental Health;Outcome;Patient Self-Report;Persons;Play;Prevention;Procedures;Process;Protocols documentation;psychologic;Psychological Factors;psychosocial;Public Health;Publications;Publishing;Records;recruit;Reporting;Research;Research Support;Risk;Risk Behaviors;Risk Factors;secondary analysis;sensor;sexual assault;social;social factors;student drinker;student drinking;Students;Symptoms;Testing;theories;Time;United States National Institutes of Health;Validity of Self Report;wearable device;willingness;Work;Wrist;young adult;young adult alcohol use

PROJECT_TITLE: Examining alcohol-induced blackouts in young adults using alcohol sensors

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: CHAISSON, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TITLE: Administrative Core


PI_NAMEs: BEYRER, CHRISTOPHER C. (contact)

PROJECT_TITLE: Developmental Core


PI_NAMEs: MOORE, RICHARD DOUGLAS (contact)

PROJECT_TITLE: Clinical Core


PI_NAMEs: CELENTANO, DAVID D. (contact)

PROJECT_TITLE: Prevention Core


NIH_SPENDING_CATS: Aging;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Pediatric;Pediatric - AIDS;Substance Misuse

PI_NAMEs: HENDRIX, CRAIG WALTER (contact)

PROJECT_TITLE: Clinical Laboratory & Biomarker Core


NIH_SPENDING_CATS: Aging;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

PI_NAMEs: LAU, BRYAN  (contact)

PROJECT_TITLE: Biostatistics & Epidemiology Methodology Core


PI_NAMEs: SCHWARTZ, SHEREE RENAE (contact)

PROJECT_TITLE: Implementation Science Core


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DURBIN, ANNA PALMER (contact)

PROJECT_TITLE: Vaccine Response and Immunotherapeutics SWG


PI_NAMEs: AGWU, ALLISON L (contact)

PROJECT_TITLE: Adolescent & Young Adult SWG


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PI_NAMEs: DE PARIS, KRISTINA ;PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative. Communication between the lymph node and the organs it drains is imperative for predicting immune responses to vaccination, infection, and chronic disease, but have been difficult to study in vivo or in vitro. To address this gap, we will develop a user friendly, microscale system specifically co-culture intact samples of live tissue from the lymph node with other organs and allow recirculating of white blood cells between them as occurs in vivo. After determining the effects of various modes of fluid motion on intact lymph node tissue for the first time, we will generate a simple model the response of the lymph node to vaccination, as a proof-of-principle of this new system for modeling multi-tissue immunity outside the body.

PI_NAMEs: POMPANO, REBECCA R (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3D Print;Address;Adjuvant;Adopted;Adoption;Air;Antigen Presentation;Antigen-Antibody Complex;Antigens;Arthritis;Autoimmunity;Bathing;Biological Models;Biology;biomaterial compatibility;Biomedical Research;Brain;cancer immunotherapy;Cancer Vaccines;Cell Culture Techniques;Cell Survival;Cells;Chronic Disease;Circulation;Coculture Techniques;Communication;Communities;Complex;cooking;design;Disease;Drainage procedure;draining lymph node;effector T cell;Electronics;Engineering;Ensure;Environment;Event;experimental study;fighting;fluid flow;Force of Gravity;Gel;Hybrids;Image;Immune;immune function;Immune response;Immunity;Immunologist;Immunology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Incubators;Infection;Inflammation;Inflammatory;Injections;innovation;interstitial;Joints;Laboratories;Lateral;Leukocytes;Liquid substance;Lymph;lymph node microenvironment;Lymph Node Tissue;lymph nodes;Lymphocyte;lymphoid organ;Magnetism;Methods;microdevice;Microfluidics;miniaturize;Modeling;Molecular;Monitor;Motion;Movement;Organ;Organ Culture Techniques;Organ Model;organ on a chip;Particulate;Pattern;Perfusion;Peripheral;predicting response;preservation;Proteins;prototype;Public Health;Pump;recruit;Reporting;Reproducibility;Research Personnel;response;Sampling;scale up;Series;simulation;Site;Skin;Slice;Stimulus;Stromal Cells;System;technology development;Testing;therapeutic evaluation;Time;Tissue Microarray;Tissues;tumor;Tumor Immunity;usability;user-friendly;Vaccination;Vaccine Design;vaccine immunogenicity;Vaccines;Viscosity;Work

PROJECT_TITLE: Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Latinx children and adolescents experience rates of anxiety and related internalizing disorders at a higher rate than other ethnic groups, but we know little about risk and protective factors for the emergence of symptoms in Latinx children. This K01 will examine the role of neural, dyadic, and cultural markers of emotional processing and regulation in the development of anxiety symptoms in young Latinx children from toddlerhood to preschool. A greater understanding of the individual, dyadic, and cultural factors contributing to an increased risk for anxiety in Latinx children could have a substantial impact on our ability to identify which Latinx children are at the highest risk of starting trajectories towards clinical levels of anxiety and could help generate culturally- tailored interventions to modify developmental trajectories away from increased symptoms in these children.

PI_NAMEs: QUINONES-CAMACHO, LAURA  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Anxiety;anxiety symptoms;anxious;anxious behavior;Area;Biological;Biological Markers;Caregivers;Child;Childhood;Clinical;Coupling;culturally appropriate intervention;Data;Data Analyses;Development;Disease;Electroencephalography;Emotional;Emotions;Environment;Ethnic Population;experience;Goals;high risk;Individual;Knowledge;Latinx;Life;life span;Link;Longitudinal Studies;Maps;Measures;Mental disorders;Mentored Research Scientist Development Award;Mentors;multidisciplinary;multimodality;National Institute of Mental Health;neural;Nursery Schools;Pattern;Process;programs;protective factors;Psychopathology;Regulation;Research;resilience;Rest;Risk;Risk Factors;Role;satisfaction;Shapes;Socialization;Symptoms;Texas;Training;Visit;Well in self;Youth

PROJECT_TITLE: Neural, dyadic, and cultural influences on risk for anxiety in young Latinx children Supplement

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Glaucoma is a complex, multifactorial disease characterized by a slow and progressive degeneration of the optic nerve, leading to visual impairment. Despite the widely appreciated disease relevance of neuroinflammation and mitochondrial dysfunction as critical pathogenic elements, the mechanisms underlying glia-mediated neuroinflammation and the contribution of compromised mitochondrial network and function in glaucoma remain unknown. The proposed study explores novel pathways of potential links between AIBP and neuroinflammation, cholesterol efflux and mitochondrial function, and develops new therapy for glaucoma

PI_NAMEs: CHOI, SOO-HO ;JU, WONKYU  (contact);KIM, KEUNYOUNG

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: adenovirus mediated delivery;Apolipoprotein A-I;ATP-Binding Cassette Transporters;Autophagocytosis;Axon;Binding;Binding Proteins;Bioenergetics;Biological Assay;Blindness;Cell Communication;Cell Death;Cell Survival;Cells;Cholesterol;Cholesterol Homeostasis;Clinical Research;Coculture Techniques;Complex;complex IV;cytochrome c oxidase;Development;Dimerization;Disease;Electroretinography;Elements;experimental study;extracellular;Flow Cytometry;Functional disorder;Genes;Genus Hippocampus;Glaucoma;Histologic;Histological Techniques;Human;Imaging technology;In Vitro;in vivo;Inflammasome;Inflammatory;Inflammatory Response;Interleukin-1 beta;intravitreal injection;Link;LOC118430 gene;Measures;Mediating;Membrane;Membrane Microdomains;Methods;Microscopic;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Mixed Function Oxygenases;Molecular;Molecular Analysis;Muller's cell;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;neuroprotection;novel;novel therapeutics;Optic Nerve;optic nerve disorder;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Physiologic Intraocular Pressure;Play;preservation;pressure;prevent;Primary Open Angle Glaucoma;Process;Protein Deficiency;protein expression;Protein Overexpression;Protein Secretion;Proteins;receptor;Recombinants;Recovery of Function;Regulation;Respiration;response;Retina;Retinal Ganglion Cells;Role;Signal Transduction;Single Nucleotide Polymorphism;Stress;Synapses;System;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;TLR4 gene;tomography;Variant;vector;Vision;Visual evoked cortical potential;Visual impairment;Visual Pathways;Visual System;Work

PROJECT_TITLE: AIBP-mediated neuroprotection in glaucomatous optic neuropathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed project seeks to develop and pilot test a mental health support intervention (Weyera) to build resilience among Ethiopian and Eritrean emerging adults. This project is relevant to public health because Black immigrant-origin groups, including Ethiopian and Eritrean emerging adults, are a large and growing population who encounter significant mental health challenges that remain unaddressed.

PI_NAMEs: HUSSEN, SOPHIA A. (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adolescent;Adoption;African;Age;American;Anxiety;anxiety symptoms;Area;Attention;Belief;Black American;Black Populations;Black race;care seeking;Child;clinically significant;Collaborations;Communities;Community Health Aides;community partners;community partnership;control trial;coping;Country;Data;depressive symptoms;Development;Discrimination;Eastern Africa;efficacy trial;emerging adult;Enrollment;Eritrea;Ethiopia;Ethiopian;ethnic identity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;experience;Face;Family;Feedback;Foundations;Future;General Population;Generations;Goals;group intervention;Health;health disparity;health service use;Immigrant;Immigration;improved;Individual;intergenerational;Intervention;intervention mapping;intervention refinement;Interview;Knowledge;Mental Depression;Mental Health;Mental Health Services;Methods;Monitor;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Outcome;outcome disparities;Pathological anxiety;Personal Satisfaction;pilot test;pilot trial;Politics;Population;Population Sizes;Post-Traumatic Stress Disorders;primary outcome;Probability;Process;process evaluation;promote resilience;Public Health;Publishing;Qualitative Research;Race;racism;Randomized;Refugees;Research;Research Personnel;resilience;resilience factor;Safety;secondary outcome;social;Social support;Sociology;Stream;Structure;Students;Subgroup;Surveys;symptomatology;Testing;therapy design;therapy development;Training;transition to adulthood;Trauma;trauma symptom;traumatic stress;United States;United States National Institutes of Health;Violence;Waiting Lists;Well in self;Work;Youth

PROJECT_TITLE: Developing and Pilot Testing a Mental Health Support Intervention for Ethiopian and Eritrean Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Infectious Diseases;Liver Disease;Microbiome;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Preclinical and clinical studies show that the intestinal microbiota regulates innate and adaptive immunity, including T cell and antitumor immunity, after allogeneic hematopoietic cell transplantation. Although hematopoietic cell transplantation is a potentially curative therapy, graft-versus-host disease is a major complication caused by donor T cells. The major goal of this proposal is to ameliorate graft-versus-host disease and improve outcomes in allogeneic hematopoietic cell transplantation recipients by targeting bile acids, which are potential regulators of the microbiome and donor T cells, using strategies informed by preclinical and clinical studies.

PI_NAMEs: CROSS, JUSTIN ;VAN DEN BRINK, MARCEL R M (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acids;Acute Graft Versus Host Disease;adaptive immunity;Allogenic;Anaerobic Bacteria;antimicrobial;Bacteria;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;bile salts;Binding;Biochemical;Biological;Blood;Butyrates;cancer recurrence;Cells;Chenodeoxycholic Acid;chronic graft versus host disease;Clinic;Clinical Research;Clinical Trials;Collection;commensal bacteria;Complication;curative treatments;Data;Digestive Physiology;Disease;Disease Outcome;Engraftment;Enterococcus;experience;Feces;Funding;Gastrointestinal tract structure;Generations;Goals;graft vs host disease;gut microbiome;gut microbiota;Hematopoietic Stem Cell Transplantation;Homeostasis;Human;Hydrolase;immune reconstitution;Immunity;Immunologics;improved;improved outcome;Infection;Inflammation;intestinal epithelium;Intestinal Graft Versus Host Disease;Investigation;Liver;Malignant - descriptor;Manuscripts;metabolomics;microbial;microbiome;microbiota;mouse model;Mucous Membrane;Multicenter Studies;Mus;Natural Immunity;Nature;next generation sequencing;Non-Malignant;Nuclear Receptors;Outcome;pathogenic bacteria;Pathology;Patients;Plasma;Pre-Clinical Model;preclinical study;Property;receptor;Receptor Activation;reconstitution;recurrent infection;Regulatory T-Lymphocyte;Relapse;Research;Risk;Role;Sampling;Science;Series;Serum;Signal Transduction;T-Lymphocyte;Translating;Transplant Recipients;tumor;Tumor Immunity;Work

PROJECT_TITLE: The role of bile acid metabolomics in graft-versus-host disease

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Fatal and nonfatal drug overdoses are on the rise in adolescents, an age group with unique characteristics and risks. The proposed project will use nationwide, longitudinal data for publicly insured, high-risk adolescents to provide estimates on drug overdose prevalence, treatment receipt and timing, and repeat overdose incidence, along with identifying risk factors at key points in the trajectory from first to repeat overdose. The findings will generate essential knowledge about high-risk adolescent subgroups to inform targeted prevention and treatment strategies.

PI_NAMEs: BUSHNELL, GRETA  (contact);SAMPLES, HILLARY

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adolescent;Adult;Age;age group;aged;Behavior Therapy;behavioral health;Buprenorphine;Caring;Cause of Death;Characteristics;Clinical;clinical care;combat;Counseling;critical period;Data;Development;Diagnosis;Disparity population;Effectiveness;effectiveness study;Emergency department visit;Epidemiology;ethnic minority;Ethnic Origin;Event;evidence base;experience;falls;Female;Fentanyl;follow-up;foster care;Future;Goals;Health Services Accessibility;Healthcare;high risk;high risk population;high-risk adolescents;Hospitalization;Incidence;indexing;Individual;Integrated Health Care Systems;Intervention;Knowledge;male;manufacture;Mechanical ventilation;Medicaid;Mental disorders;Mental Health;Modality;Morbidity - disease rate;mortality;non-opioid analgesic;novel;Opioid;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;overdose prevention;overdose risk;Patients;Pattern;Pharmaceutical Preparations;Pharmacological Treatment;Poisoning;Population;Prevalence;prevent;Prevention strategy;Proliferating;Psychiatric Diagnosis;psychostimulant;Psychotherapy;Psychotropic Drugs;Race;racial minority;Recording of previous events;Research;Resource Allocation;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Reduction;Sampling;Self-Injurious Behavior;sex;Single-Payer System;sociodemographics;Source;Stimulant;structural determinants;Subgroup;Substance Use Disorder;Suicide;Symptoms;treatment pattern;treatment strategy;Variant;vulnerable adolescent

PROJECT_TITLE: Informing national overdose prevention and treatment strategies for high-risk adolescents


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Compared to cisgender youth, transgender youth are more likely to be diagnosed with depression or anxiety, and much more likely to attempt suicide. These mental health inequities are exacerbated by mental healthcare barriers faced by transgender youth, such as discrimination. This trial aims to optimize an implementation package to increase adoption of an acceptable, feasible, and effective gender-affirming care intervention, Gender-Affirming Psychotherapy (GAP).

PI_NAMEs: PRICE, MAGGI  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Administrative Supplement;Adoption;Anxiety;Attitude;cisgender;Clinic;Data;Development;Diagnosis;Discrimination;Dropout;Educational Intervention;Effectiveness;experience;gender affirmation;gender affirming care;gender minority youth;health equity;health inequalities;Healthcare Systems;Hour;implementation outcomes;implementation strategy;improved;Incentives;Intervention;Knowledge;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;Modeling;Names;Outcome;Patients;Persons;pilot test;pilot trial;Provider;Psychotherapy;relative cost;Research;satisfaction;Self Efficacy;skills;success;Suicide attempt;Training;transgender;transphobia;Youth

PROJECT_TITLE: Development of a Training Intervention to Improve Mental Health Treatment for Gender Minority Youth: Administrative Supplement

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE CHIP is a key enzyme in cellular protein quality control. On a cellular level, altered CHIP function sensitizes cells to stress, and at an organismal level, the inability to respond to stress results in degenerative pathologies and accelerated aging. Our overall goal is to determine the mechanisms and dysfunction caused by disease-causing CHIP mutations at the atomic, cellular, and whole-body level. We will use novel cell systems in combination with our preclinical models to test novel therapies to counteract the loss of CHIP function. In doing so, we will establish a new framework to better understand this aging and CHIP biology that, in turn, will allow us to develop precision medicine approaches to alleviate degeneration caused by the loss of CHIP function.

PI_NAMEs: SCHISLER, JONATHAN C. (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;Active Sites;Adult;age acceleration;age effect;age related;age-related disease;Aging;Alzheimer's Disease;Apoptosis;Atrophic;autosome;Binding Proteins;Biochemical;Biology;biophysical techniques;Body System;Cardiovascular Diseases;Cell Culture Techniques;Cell Death;Cell model;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Stress;Cerebellar Ataxia;Cerebellar degeneration;Cerebellum;clinical phenotype;Code;Cognition;Complex;Defect;Degenerative Disorder;Disease;disease-causing mutation;druggable target;Energy Metabolism;engineered stem cells;Enzymes;flexibility;Functional disorder;Genetic Diseases;Goals;Health;Heart failure;Heat-Shock Response;human disease;Human Genetics;Hypogonadism;Impaired cognition;induced pluripotent stem cell;Inflammatory;Link;loss of function;Mediating;Mediator;member;Metabolic;Metabolic stress;Metabolism;Molecular;Molecular Chaperones;Molecular Conformation;Motor;mouse model;Movement;multicatalytic endopeptidase complex;Mus;Mutation;Nerve Degeneration;Neurologic;Neurons;novel;novel therapeutics;pathological aging;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiological;Play;pre-clinical;Pre-Clinical Model;precision medicine;Predisposition;protein degradation;protein folding;protein function;Protein Kinase Interaction;Proteins;Proteolytic Processing;proteostasis;Purkinje Cells;Quality Control;Reaction;Receptor-Interacting Protein;Regulation;response;RIPK1 gene;Role;selective expression;sensor;Signal Pathway;Signal Transduction;small molecule;Spinocerebellar Ataxias;Stress;stressor;System;Testing;Tissues;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Protein quality control in age-related diseases

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health since it focuses on understanding the immune evasion mechanism deployed by the human pathogen Schistosoma mansoni. Completion of the proposed study will bring new insights to how schistosomes operate inside the human host and identify potential targets for future therapeutic design that could aid in combating schistosomiasis.

PI_NAMEs: LEE, JAYHUN  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Anterior;Atlases;Binding;Biological Assay;Biology;Blood;Blood Circulation;Candidate Disease Gene;cell type;Cells;Cessation of life;chemotherapy;comparative;Complement;Coupled;Cytolysis;Cytoplasm;Data;design;Development;Endowment;Ensure;Environment;esophageal gland;Esophagus;Exons;feeding;fighting;forkhead protein;Future;Gastrointestinal tract structure;Genes;Gland;Goals;Heterogeneity;Homeostasis;Human;human pathogen;Immune;Immune Evasion;Immune system;Immunocompromised Host;Immunoglobulins;In Situ Hybridization;In Vitro;in vivo;Individual;Ingestion;innovation;insight;interest;knock-down;Leukocytes;Link;Maintenance;Mass Spectrum Analysis;Mediating;Molecular;Mus;new therapeutic target;novel;Organ;Parasites;Penetration;Physiologic pulse;Platyhelminths;Play;Praziquantel;prevent;protein function;Proteins;Public Health;Publishing;Research;RNA Interference;Role;Schistosoma;Schistosoma mansoni;Schistosomiasis;Site;Skin;stem cells;Therapeutic;therapeutic target;Tissue atlas;Tissues;transcriptome sequencing;transcriptomics;Transplantation;Vaccines;Work

PROJECT_TITLE: Esophageal gland-mediated immune evasion by the human parasite Schistosoma mansoni

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative  Many people with aphasia experience challenges in conveying their thoughts to unfamiliar communication partners. This project will advance public health by contributing fundamental knowledge about what helps unfamiliar communication partners understand people with aphasia. By investigating whether aphasia identification cards enhance unfamiliar communication partners’ comprehension, this project aims to help people with aphasia convey their thoughts, thereby strengthening their independence and social connections.

PI_NAMEs: MACK, JENNIFER ELAINE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Advocacy;Advocate;Affect;Age;aged;Aphasia;Attention;Attitude;Behavior;Belief;Brain;Communication;Comprehension;Data;Emotions;Enrollment;Ethnic Origin;experience;Experimental Designs;experimental study;Food;Gender;Goals;Hearing;improved;Independent Living;Intervention;Knowledge;Language;language comprehension;Language Disorders;language processing;Linguistics;Measures;Modeling;Mus;Occupations;Outcome;Partner Communications;Persons;Pharmaceutical Preparations;Process;process improvement;Process Measure;Public Health;Race;Randomized;Randomized, Controlled Trials;repaired;Reporting;Research;response;Retrieval;sample fixation;Scientific Advances and Accomplishments;Services;social;Social Interaction;Surveys;Testing;Thinking;Time;Transportation;Visual;visual tracking;Writing

PROJECT_TITLE: Effects of Aphasia Identification Cards on Comprehension of Aphasic Language by Unfamiliar Communication Partners.

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Aging;Biotechnology;Kidney Disease

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Currently, there are no effective therapies to preserve kidney function, which declines with age and following acute kidney injury. As a result, many patients develop chronic kidney disease and face long-term complications such as cardiovascular events and reduced quality of life. By investigating how distinct cellular pools of NAD+ promote kidney health during injury, we aim to generate fundamental new insights in kidney biology and pave the way to urgently needed kidney therapeutics.

PI_NAMEs: KAPITSINOU, PINELOPI P. (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;age related decline;Aging;Automobile Driving;Biological Process;Biology;Biosensor;Blood Circulation;Cardiovascular system;Cell Physiology;Cells;Chronic Kidney Failure;Citric Acid Cycle;cofactor;Complex;Cytoplasm;Cytoprotection;Cytosol;Data;Development;Disease;Disease Progression;Drug Kinetics;Ectopic Expression;effective therapy;Electron Transport;Electrons;Energy Metabolism;Ensure;Enzymes;Epithelial Cells;Event;experimental study;Face;fascinate;Fibrosis;Generations;Genes;genetic manipulation;Genetic Recombination;Genetic Transcription;Genetically Engineered Mouse;Glycolysis;Goals;Health;Homeostasis;Human;Impairment;improved;in vivo;inducible gene expression;Inflammation;Injury;Injury to Kidney;insight;Investigation;Ischemia;Kidney;Kidney Diseases;kidney fibrosis;kidney preservation;Knock-in Mouse;Knowledge;Lactobacillus brevis;Link;Mediating;Metabolic;metabolomics;Mitochondria;mitochondrial metabolism;Molecular;mouse model;Mus;NADH;NADH oxidase;NADP;Natural regeneration;Nicotinamide adenine dinucleotide;novel;novel therapeutics;old mice;older patient;Organ;Oxidation-Reduction;Patients;Physiology;Play;prevent;Production;Publishing;Quality of life;Regulation;Renal function;renal ischemia;Renal tubule structure;repaired;Reporting;resilience;response;Role;Scheme;Signaling Molecule;solute;sonar;Stress;Supplementation;System;Technology;Therapeutic;Tissues;transcriptomics;Transgenic Mice;Transgenic Organisms;Translating;Tubular formation;Urine;Validation;Waste Products;Water

PROJECT_TITLE: Compartment-specific manipulation of NAD+ to mitigate post-injury kidney disease.

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Cocaine use negatively impacts an individual’s health and quality of life and affects a substantial burden on communities and society. The proposed research program will investigate changes in brain chemistry and functioning that may be associated with chronic cocaine use, promote relapse, and complicate treatment efforts. A better understanding of these neurobiological changes, and particularly the relationship between altered neurotransmitter systems and brain function, may inform more effective treatment strategies, improving quality of life and reducing societal burden.

PI_NAMEs: ANGARITA, GUSTAVO ADOLFO (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Abstinence;Acetylcholine;Achievement;addiction;Address;Admission activity;Affect;Agonist;Animal Model;antagonist;Area;Behavior Therapy;Brain;Brain Chemistry;CHRM1 gene;Chronic;Clinical Trials;Cocaine;cocaine use;Cocaine use disorder;cognitive enhancement;cognitive function;Communities;Complex;Confidence Intervals;Corpus striatum structure;Data;Data Collection;Desire for food;Development;Dopamine;effective intervention;effective therapy;Equilibrium;expectation;experience;frontal lobe;Functional Magnetic Resonance Imaging;Glutamates;Health;Hippocampus;Human;improved;in vivo;Individual;innovation;insight;interest;Intervention;Investigation;Knowledge;Link;Magnetic Resonance Imaging;maladaptive behavior;Measures;Midbrain structure;Muscarinic M1 Receptor;Muscarinics;National Institute of Drug Abuse;Neurobiology;Neurocognitive;neurocognitive test;neuromelanin;Neuronal Plasticity;Neurotransmitters;novel;overdose death;Parietal Lobe;Participant;Pathway interactions;Performance;pharmacologic;Pharmacotherapy;Phase;Phased Innovation Awards;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;pre-clinical research;Prevalence;Procedures;Process;programs;Public Health;Quality of life;radiotracer;receptor;receptor function;Recovery;recruit;Relapse;Research;Research Design;Research Domain Criteria;Resistance;Rest;Rewards;Role;Sampling;Sensory Receptors;Societies;System;Tail;Therapeutic;Time;treatment strategy

PROJECT_TITLE: Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Complementary and Integrative Health;Digestive Diseases;Microbiome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: NEUROLOGY

PHR: NARRATIVE This study seeks to investigate the effect of dysbiotic intestinal bacteria on absorption of short-chain fatty acid (SCFAs) by intestinal epithelial cells, their transport into the systemic circulation, and development of experimental autoimmune encephalomyelitis (EAE). This study will also explore the effect of probiotic and synbiotic treatments with Blautia massiliensison, Anaerobutyricum hallii, and high-fiber supplements on the transport of SCFAs and development of EAE.

PI_NAMEs: DHIB-JALBUT, SUHAYL S.;ITO, KOUICHI  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: absorption;Acetates;Affect;Animal Model;Autoimmune Diseases;Bacteria;Biological Markers;Blood;Blood Circulation;Blood specimen;Butyrates;Cells;Circulation;Clinical;Clinical Trials;CNS autoimmunity;Colon;cytokine;Data;Development;Diet;Disease;Disease Progression;disorder prevention;dysbiosis;Energy-Generating Resources;Epithelial Cells;Epithelium;Exhibits;Experimental Autoimmune Encephalomyelitis;fatty acid transport;Fermentation;Fiber;Genes;Germ-Free;gut bacteria;gut dysbiosis;gut health;gut inflammation;gut microbiome;gut microbiota;Health;Health Promotion;Homeostasis;Human;human microbiota;Hypertension;Immune;Immunization;immunoregulation;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;Intake;interest;Interferon Type II;Intervention;Intestinal Absorption;intestinal epithelium;Intestinal permeability;Intestines;Lamina Propria;LCN2 gene;Lymphoid Tissue;Maintenance;MCT-1 gene;Membrane;Metabolic Diseases;microbial;microbiome;microbiota transplantation;microorganism;Modeling;Multiple Sclerosis;multiple sclerosis patient;Mus;Nervous System Disorder;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Pathogenicity;Patients;Permeability;Play;Poison;prebiotics;probiotic therapy;Probiotics;Production;Propionates;Proteins;Regulatory T-Lymphocyte;Reporting;Rest;Role;Serum;stool sample;System;Testing;Therapeutic;Tight Junctions;Tissues;TNF gene;Transplantation;Vesicle;Volatile Fatty Acids

PROJECT_TITLE: Effect of dysbiotic gut microbiota on the transport of short-chain fatty acids: Relevance to autoimmune disorders

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This supplement will support the acquisition of two Repligen® KrosFlo® KR2i Tangential Flow Filtration (TFF) Systems to support silk fibroin protein purification directly related to on-going efforts within “Leveraging biodiversity and utilizing genetic engineering to expand the structure and function of silk fibroin biopolymers for biomedical applications.” The TFF systems will support the purification of solubilized Plodia interpunctella silk fibroin, a protein within the silk fiber of an agricultural pest, evaluating two methods of purification based on the protein sequence: size exclusion chromatography and affinity chromatography. These systems were specifically chosen based on their ability to monitory conductivity within the solutions during purification, to enable development of standard operating procedures that can be appropriately scaled for future applications in biomanufacturing.

PI_NAMEs: STOPPEL, WHITNEY L (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Affinity Chromatography;Agriculture;Amino Acid Sequence;aqueous;Award;Bacteria;Binding;Biochemical;Biodiversity;Biomanufacturing;Biophysics;Biopolymers;Bombyx;Bombyx mori;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;design;Development;Embryo;Equipment;Fiber;Fibroins;Filtration;Future;Gene Modified;Genetic Engineering;Goals;Growth Factor;Healthcare;Human;Humidity;Immune response;implantation;improved;In Vitro;in vivo;Injections;Interruption;Investigation;Lepidoptera;Life Cycle Stages;Mammalian Cell;manufacture;mechanotransduction;Medical Device;Medicine;Methods;Modification;Molecular Sieve Chromatography;Moths;Muscle rehabilitation;National Institute of General Medical Sciences;Natural regeneration;Outcome;pathogen;Peptides;Pharmacologic Substance;Phase;Phenotype;Polymers;Population;Procedures;Process;Production;protein aminoacid sequence;protein purification;Proteins;Pupa;Research;Research Personnel;scale up;Silk;Site;Solvents;Stimulus;Structure;success;System;Tissue Engineering;tool;Transcriptional Regulation;Translations;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: AWD12927 Admin Supplement Equipment