NIH_SPENDING_CATS: Cancer;Clinical Research;Eye Disease and Disorders of Vision;HIV/AIDS;Immunotherapy;Infectious Diseases;Prevention

PHR: PROJECT NARRATIVE – PROJECT 2 Conjunctival squamous cell carcinoma (cSCC) is an eye cancer with unknown etiology that disproportionately impacts sub-Saharan Africa, a setting where presentation with advanced disease is common and prevalence of Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) infection is high. People living with HIV (PLWH), a population highly susceptible to virus-associated cancers, have a pronounced elevation of cSCC cancer incidence, suggesting a potential viral etiology for this tumor. Project 2 seeks to determine if EBV infection is causally linked to the development of cSCC in PLWH in sub-Saharan Africa, laying the groundwork for future development of EBV targeted therapeutics and early detection biomarkers of cSCC.

PI_NAMEs: BOROK, MARGARET ZIONA (contact)

PROJECT_TERMS: advanced disease;Africa South of the Sahara;Age;AIDS related cancer;Antibodies;Benign;biobank;Biological Markers;biological sex;biological specimen archives;Blindness;Blood;Cancer Etiology;cancer risk;Carcinoma;CD3 Antigens;CD8B1 gene;Cells;Clinic;Clinical;comparison control;Conjunctival Squamous Cell Carcinoma;CTLA4 gene;Cutaneous;Data;Detection;Development;Diagnosis;DNA analysis;early detection biomarkers;Early Diagnosis;Economics;Enrollment;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Etiology;Evaluation;Exclusion;exhaustion;Eye;FOXP3 gene;Frequencies;Future;Genetic Transcription;Goals;Grouping;High Prevalence;HIV;HIV Infections;Hospitals;Household;Human Herpesvirus 4;Human Papillomavirus;Immune;immune cell infiltrate;immune checkpoint;Immune response;Immunologic Markers;Immunosuppression;Impairment;Incidence;Individual;Infection Control;International Agency for Research on Cancer;Investigation;Kaposi Sarcoma;Laboratories;Lesion;Link;Malignant - descriptor;Malignant neoplasm of cervix uteri;malignant neoplasm of eye;Malignant Neoplasms;Measures;Morbidity - disease rate;mortality;novel;Oncology;Ophthalmologic Surgical Procedures;Outcome;Participant;Patients;Pattern;Persons;Population;Predisposition;Prevalence;Preventive;Productivity;programmed cell death ligand 1;programmed cell death protein 1;Public Health;Reporting;Research;Risk;Risk Factors;Role;sex;Specimen;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;Translating;tumor;Tumor Tissue;Tumor-infiltrating immune cells;Viral;viral detection;viral DNA;Viral Proteins;Virus;Virus Diseases;virus related cancer;Vital Status;Zimbabwe

PROJECT_TITLE: Project 2: Novel investigation of Epstein-Barr virus as a potential cause of conjunctival squamous cell carcinoma among people living with HIV in Zimbabwe


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: OVERALL Cancer cachexia contributes to approximately a third of all cancer deaths, but currently no effective therapy exists to combat this malignant syndrome. This Program Project brings together unique concepts and important resources to advance our conceptual understanding of pancreatic cancer-induced cachexia.

PI_NAMEs: GUTTRIDGE, DENIS C (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acceleration;Adipose tissue;Anticachexia Agent;Belief;Biological Markers;Biometry;Body Weight;Body Weight decreased;bone imaging;Cachexia;Cancer Cachexia;cancer imaging;Cancer Patient;Cells;Cessation of life;Collaborations;combat;Communities;Data;Dietary Intervention;effective therapy;Exhibits;Fatigue;Fatty acid glycerol esters;Fibroblasts;Future;Goals;Human;Immune;Immunophenotyping;improved;improved outcome;Incidence;Indiana;Inflammation;innovation;insight;Interleukin 6 Receptor;Interleukin-6;Literature;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Medical;Mesenchymal;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Muscle;muscle progenitor cell;Muscular Atrophy;Myomatous neoplasm;NCI-Designated Cancer Center;next generation sequencing;novel;Organization administrative structures;Outcome;Pancreatic Ductal Adenocarcinoma;Patients;Peripheral;Population;preclinical study;Prognosis;programs;Publishing;Quality of life;Resources;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Solid Neoplasm;South Carolina;spectrograph;standard of care;STAT3 gene;Survival Rate;Syndrome;Testing;Therapeutic;therapeutic target;Thinness;Time;Tissue Banks;Tissues;Translating;treatment response;tumor;Tumor Burden;tumor microenvironment;tumor progression;Universities;wasting;Weight;Weight Gain

PROJECT_TITLE: The role of the macroenvironment in pancreatic cancer-induced cachexia


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE: PROJECT 1 Body weight loss in pancreatic cancer, recognized as progressive wasting of fat and muscle, is frequent and severe, reducing quality of life and response to therapy and increasing mortality. In partnership with the other Projects in this Program, we seek to understand how the tumor, fat and muscle communicate to each other within the body of an individual with pancreatic cancer. Using tissues from mouse models and from surgical pancreatic cancer patients, and blood samples and clinical data from an ongoing pancreatic cancer clinical trial, we will apply advanced analytical techniques including at the single cell level to identify new molecular targets to improve treatment and quality of life in patients with pancreatic cancer.

PI_NAMEs: ZIMMERS, TERESA A (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;advanced analytics;Antibodies;Anticachexia Agent;Atrophic;Blood;Blood specimen;Body Weight decreased;Cachexia;Cancer Cachexia;cancer clinical trial;cancer therapy;Cells;Cessation of life;chemotherapy;Chronic;Clinical Data;Clinical Trials;Communication;Data;Disease;effective therapy;fat wasting;Fatty acid glycerol esters;Genetic;Genetic Models;Genotype;Human;IL6 gene;Immune;improved;Individual;Inflammation;Interleukin-6;Intervention;Knock-out;Lipids;Lipolysis;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;Molecular Target;mortality;mouse model;Muscle;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;NF-kappa B;novel;Pancreatectomy;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Performance Status;phase II trial;preclinical study;preservation;Production;Program Research Project Grants;programs;Proteome;Quality of life;reduced muscle mass;Resolution;response;Role;Severities;Signal Transduction;single nucleus RNA-sequencing;Skeletal Muscle;Source;Specimen;STAT3 gene;Techniques;Testing;Tissues;tocilizumab;treatment response;Treatment-related toxicity;tumor;tumor microenvironment;tumor progression;uptake;wasting

PROJECT_TITLE: Project 1 – IL-6/STAT3/NF-kB in Adipose-Muscle Crosstalk in the Pancreatic Cancer Macroenvironment


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Rare Diseases;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE – DATA MANAGEMENT & STATISTICS CORE The overarching goal of the Data Management & Statistics Core (DMSC) for the artnership to ssess iral and Immune andscape Intersections with cology for People Living with HIV (PAVILION) is to provide comprehensive statistical design, data management, and analysis in support of conducting rigorous and reproducible research by PAVILION investigators who are working to make strides in understanding the proportion of tumors whose etiology is attributable to the human papillomavirus (HPV) and Epstein-Barr virus (EBV) among people living with HIV in sub-Saharan Africa including such rare tumor types as anal, cervical, conjunctival, oropharyngeal, penile, and vulvar cancers. The DMSC has designed a robust yet flexible pipeline that builds upon the extensive infrastructure and long-term international collaborations established by the PAVILION partnering investigators and leverages the extensive investment by Moffitt Cancer Center in biostatistics, bioinformatic, informatic, and computing capabilities as well as the depth and breadth of expertise in the analysis of basic, translational, clinical, and large-scale cancer epidemiological studies to address project aims and build biostatistical capacity at Stellenbosch University (South Africa) and University of Zimbabwe, the PAVILION low- and middle-income country (LMIC) sites. Further, the DMSC will provide education and training through lectures and mentorship in biostatistics to members and research staff, with the goal of building the expertise and capacity of the LIMC partner sites to lead future studies/trials. P A V L On

PI_NAMEs: SCHELL, MICHAEL JOSEPH (contact)

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;Anus;Award;Bioinformatics;biological specimen archives;Biometry;Biostatistical Methods;Cancer Center;cancer epidemiology;career;Cervical;Clinical;Clinical Management;Clinical Protocols;Clinical Research;Collaborations;Communities;Consult;Data;data management;data repository;Databases;design;Development;Education;Ensure;epidemiology study;Etiology;Experimental Designs;flexibility;Future;Genetic Transcription;Goals;Guidelines;HIV;Housing;HPV analysis;Human Herpesvirus 4;Human Papillomavirus;Immune;Immunofluorescence Immunologic;Informatics;Infrastructure;International;Investigation;investigator training;Investments;Knowledge;Laboratories;Lead;lectures;low and middle-income countries;Malignant neoplasm of penis;Malignant neoplasm of vulva;malignant oropharynx neoplasm;Manuscripts;member;Mentorship;Methodology;Monitor;Oncology;Peer Review;Persons;Phase;Pilot Projects;Policies;Population;power analysis;Procedures;protocol development;Publications;Qualifying;Questionnaires;rare cancer;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resources;Sample Size;Serology;Site;South Africa;Statistical Data Interpretation;statistics;Training and Education;Translational Research;tumor;Tumor-infiltrating immune cells;Universities;Viral;viral DNA;virtual;Work;Writing;Zimbabwe

PROJECT_TITLE: Data Management & Statistical Core


ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: OVERALL: NARRATIVE The Northwestern Brain Tumor SPORE is for improving treatment outcomes for patients afflicted with highly malignant primary brain tumors, with particular emphasis on glioblastoma. This goal will be accomplished through the efforts of a talented group of investigators that will combine complementary expertise in a team science approach leading to meaningful progress in effectively treating tumors that currently have a dismal prognosis.

PI_NAMEs: LESNIAK, MACIEJ S (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Anabolism;anti-PD-L1;arm;Autologous;B-Lymphocytes;Biogenesis;Biological Markers;biomarker identification;Brain;Brain Neoplasms;Canis familiaris;Catheters;CD8-Positive T-Lymphocytes;Cells;Cellular Stress;Characteristics;chemoradiation;Clinical Data;Clinical Trials;cohort;Complex;conditionally replicative adenovirus;cytotoxicity;Data;Diagnosis;Disease;DNA Damage;efficacy evaluation;Enzymes;Faculty;first-in-human;Future;Glioblastoma;Glioma;Goals;Human;human study;Immune response;Immunity;Immunotherapeutic agent;IMPDH2 gene;improved;improved outcome;Incidence;Individual;Inflammatory;Infusion procedures;Injections;interdisciplinary approach;Interferon Type II;Interferons;Intracranial Neoplasms;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;member;MGMT gene;Modeling;Molecular;Monitor;mouse model;Mus;mycophenolate mofetil;N-Acetylcysteinamide;Nature;Neoplasms;nerve stem cell;Newly Diagnosed;novel;novel therapeutics;oncolytic adenovirus;oncolytic virotherapy;Operative Surgical Procedures;Organ;Outpatients;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Persons;Phase;Physiologic pulse;Positron-Emission Tomography;pre-clinical;pre-clinical research;Prediction of Response to Therapy;Predisposition;prevent;Primary Brain Neoplasms;Prognosis;programs;Public Health;Purines;Radiation;Records;Recurrence;Research;Research Personnel;response;response biomarker;safety and feasibility;Science;sensor;standard of care;statistics;STING agonists;success;survivorship;System;T-Lymphocyte;Talents;temozolomide;Testing;Therapeutic;therapeutic vaccine;Time;TNFRSF5 gene;translational approach;Translations;Treatment Efficacy;treatment optimization;Treatment outcome;tumor;Tumor Antigens;Vaccines

PROJECT_TITLE: SPORE for Translational Approaches to Brain Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Social Determinants of Health

ORG_CITY: BEIJING

ORG_COUNTRY: CHINA

ORG_FIPS: CH

ORG_NAME: PEKING UNIVERSITY

PHR: Project Narrative The China Health and Retirement Longitudinal Study (CHARLS) has already begun to enrich the international landscape of aging studies. CHARLS follows closely the existing Health and Retirement Studies around the world in order to provide the capability for scholars to engage in comparative studies as well as studies of the special conditions in China. The first four national waves of CHARLS were fielded in 2011, 2013, 2015 and 2018 and waves 5 and 6 are planned for 2021 and 2024; including updates of the CHARLS Harmonized Cognitive Assessment Protocol (HCAP) of Alzheimers Disease and Related Dementias (ADRD).

PI_NAMEs: STRAUSS, JOHN A;WANG, YAFENG  (contact);ZHAO, YAOHUI

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adult;Age;Age Years;aged;Aging;Alzheimer's disease related dementia;Attention;Baseline Surveys;Biological Assay;Biological Markers;Biomass;Blood;Blood Pressure;Blood specimen;Blood Tests;Books;Brazil;care burden;Characteristics;Child Care;China;Chinese;Chinese population;Clinics and Hospitals;Coal;Cognition;cognitive testing;Collection;Comparative Study;cooking;cost;Cost Savings;Country;County;Data;Data Collection;Data Set;Dementia;Development;Dimensions;England;Environment;Epidemiology;ethical, legal, and social implication;Event;Exclusion;Family;follow-up;Foundations;Frequencies;Funding;Future;genetic analysis;Goals;Grant;Health;Health and Retirement Study;Health behavior;Health care facility;Health Insurance;Health Status;Height;Household;human old age (65+);India;Individual;Influentials;Information Services;International;Internet;Journals;Life;life history;Light;Link;Long-Term Care for Elderly;Long-Term Care Insurance;Longitudinal Studies;Measures;Mexico;Natural Sciences;nutrition;Older Population;Outcome;Paper;Pattern;Pensions;Periodicity;Persons;Physical Function;Plasma;Policies;Positioning Attribute;Primary Care;Private Hospitals;programs;prospective;Protocols documentation;Province;Publishing;rapid growth;Recontacts;Research;Research Personnel;Resources;Respondent;Retirement;Running;Rural;Rural Health;Sampling;Science;Sister;socioeconomics;Source;South Africa;Speed;Spouses;Surveys;symposium;Tibet;Time;Training;United States;Update;Urban Community;Venous;Vitamin D;Wages;Weight;Whole Blood

PROJECT_TITLE: China Health and Retirement Longitudinal study

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE: PROJECT 2 Cachexia is a syndrome of cancer that promotes severe weight loss and is a major contributor to patient morbidity and mortality. Finding an effective cachexia therapy should improve a patient’s quality of life, but potentially also increase their tolerance to more aggressive anti-cancer treatments to improve survival.

PROJECT_TERMS: adaptive immunity;Adipose tissue;adverse outcome;anti-cancer treatment;Body Weight;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;Cessation of life;chemotherapy;combat;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Disease;Eating;effective therapy;Fatigue;GDF15 gene;Genes;Goals;Human body;Immune;Immunologic Surveillance;Immunology;immunoregulation;improved;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;insight;Interleukin-6;Knowledge;Laboratories;Ligands;Link;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Fibers;muscle form;muscle progenitor cell;muscle repair;Muscular Atrophy;Myomatous neoplasm;Natural Immunity;neoplastic cell;novel;novel therapeutics;Oncology;Operative Surgical Procedures;pancreas development;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Play;prevent;Production;progenitor;Program Research Project Grants;programs;Property;Publishing;Quality of life;Radiation therapy;Registries;Regulation;repaired;Reporting;Research;Research Personnel;response;Risk;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;STAT3 gene;stem cells;Survival Rate;Syndrome;T-Lymphocyte;Testing;Tissues;Transcription Coactivator;transcription factor;tumor;Tumor-infiltrating immune cells;Weight

PROJECT_TITLE: Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – CENTRAL LABORATORY CORE The overarching goal of the Central Laboratory (CL) Core for the artnership to ssess iral and Immune  andscape Intersections with cology for People Living with HIV (PAVILION) is to provide centralized biobanking and virologic and immunologic assessment of well annotated biospecimens in support of the proposed translational studies as well as future PAVILION pilot projects. The CL Core has designed a robust yet flexible pipeline and range of analytical methodologies that builds upon the infrastructure and long-term international collaborations established by the PAVILION partnering investigators in South Africa, Zimbabwe, the US, and Germany. The CL Core purposefully pairs this unique expertise with established laboratories in the low- and middle-income country (LMIC) partner countries to efficiently advance knowledge related to tumor and patient characteristics, which can then inform the development of effective prevention and cancer treatment interventions to reduce the burden of cancer for people living with HIV (PLWH) in LMICs disproportionately impacted by HIV. P A V L On

PI_NAMEs: SCHNEIDER, JOHANN WILHELM (contact)

PROJECT_TERMS: adjudication;Anus;biobank;Biological Assay;biological specimen archives;Biological Specimen Banks;Cancer Burden;Cancer Center;cancer therapy;CDKN2A gene;Characteristics;Classification;Collaborations;Collection;Complement;Country;Databases;design;Development;Diagnosis;digital;DNA;Ensure;Etiology;Evaluation;experience;flexibility;Future;Genetic Transcription;Genotype;German population;Germany;Goals;Guidelines;Histology;HIV;Human Herpesvirus 4;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Image;Immune;Immunofluorescence Immunologic;Immunohistochemistry;Immunologic Tests;Immunologics;Infrastructure;Institution;International;Intervention;Investigation;Knowledge;Laboratories;Leadership;low and middle-income countries;Malignant Neoplasms;Methodology;NCI Center for Cancer Research;Oncology;Oropharyngeal;Pathologic;Pathologist;Pathology;Patients;penis;Persons;Pilot Projects;Policies;Prevention;Procedures;Process;Quality Control;Research;Research Personnel;Resources;RNA;Sampling;Science;Serology;Site;Slide;South Africa;Specimen;Technology;Testing;Tissue Banks;Tissues;translational study;tumor;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Viral;Viral Cancer;viral detection;virtual;virus related cancer;virus testing;Vulva;Zimbabwe

PROJECT_TITLE: Central Laboratory Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Eye Disease and Disorders of Vision;Microbiome;Nutrition;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Choline can be metabolized by the gut microbiome to produce trimethylamine, a precursor to trimethylamine N- oxide (TMAO) which is a metabolite contributing to the development of atherosclerosis, a highly prevalent condition in the US. The purpose of this study is to clarify the interplay between dietary intake, metabolism, the gut microbiome, and vascular health by examining associations between a novel dietary pattern predictive of biomarkers of TMAO production with metabolomic profiles, the gut microbiome composition, and retinal vessel caliber. This study aligns with NHLBI’s Strategic Vision and the precision nutrition research agenda described in the 2020-2030 Strategic Plan for NIH Nutrition Research as it has potential to elucidate how overall dietary intake influences a metabolic process with atherosclerotic effects.

PI_NAMEs: BURNS, KAELYN  (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adherence;Adult;Affect;Age;Amines;Ancillary Study;arteriole;Atherosclerosis;Biological;Biological Markers;biological research;Blood Vessels;Caliber;Cardiovascular Diseases;career;Choline;Circulation;Clinical;Collection;Color;Complex;Data;Development;Diet;Dietary Assessment;Dietary Fiber;dietary guidelines;Dietary intake;Dietary Practices;digital;Disease;disorder prevention;DNA;DNA sequencing;egg;Elderly woman;Epidemiologic Methods;Epidemiologist;Event;experience;Fishes;Food;Future;Genes;Goals;gut bacteria;gut microbiome;Health;high risk;high risk men;improved;Individual;insight;Intake;Intervention;liquid chromatography mass spectrometry;Measures;Meat;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;Methods;microbiome composition;modifiable risk;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Nutrient;nutrient metabolism;Nutritional Study;Observational Study;older women;Outcome;Oxides;Pathway interactions;Plasma;Population;Postmenopause;precision nutrition;predictive marker;Prevention;Prevention Guidelines;Procedures;Production;prospective;Prospective, cohort study;Protocols documentation;Reaction;Reproducibility;Research;Research Personnel;Retina;retina blood vessel structure;Risk Factors;Sampling;Sampling Studies;skills;Standardization;stool sample;Strategic Planning;Strategic vision;Testing;Time;Training;Unhealthy Diet;United States National Institutes of Health;venule;Woman;Women's Health;young woman

PROJECT_TITLE: Application of a novel dietary pattern predictive of trimethylamine N-oxide production to examine associations with metabolomic profiles, the gut microbiome, and vascular health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: P-glycoprotein (Pgp) is a major drug efflux pump in humans, affecting the bioavailability, pharmacokinetics, and clinical efficacy of many drugs in clinical use, and causing multidrug resistance that obstructs the treatment of various diseases. This project will study the Pgp transport and efflux inhibition with designed chemical reagents, thus having direct and far-reaching implications in drug discovery.

PI_NAMEs: ZHANG, QINGHAI  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: ABCB1 gene;Address;Adverse effects;Affect;antagonist;ATP Hydrolysis;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;Blood - brain barrier anatomy;Cardiovascular Diseases;Cell membrane;Cells;Charge;chemical synthesis;Chemicals;Clinical;clinical development;clinical efficacy;clinically significant;Complex;Coupled;Cryoelectron Microscopy;Data;design;Development;Disease;Documentation;drug development;drug discovery;drug efficacy;Drug Efflux;Drug Industry;Drug Interactions;Drug Kinetics;Drug Transport;efflux pump;Epilepsy;Evaluation;Funding;glycoprotein structure;Goals;HIV;Human;Hydrophobicity;improved;indium arsenide;inhibitor;insight;Intestines;Investigational Drugs;Kidney;Lead;Learning;Libraries;Ligands;Lipid Bilayers;Literature;Liver;Malignant Neoplasms;Mediating;Membrane Proteins;Modality;Modification;Molecular;Molecular Conformation;Multi-Drug Resistance;Mutagenesis;novel;novel strategies;novel therapeutics;Pharmaceutical Preparations;pharmacologic;Play;Positioning Attribute;Predisposition;Process;Property;Rationalization;Reagent;Resolution;Role;scaffold;screening;Series;structural biology;Structure;Testing;Transmembrane Domain;Treatment Efficacy;United States Food and Drug Administration;Vacuum

PROJECT_TITLE: Inhibition or evasion of P-glycoprotein-mediated drug transport

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative The proposed research will elucidate the patterns of single-neuron and population brain activity that underlie both human navigation and memory for spatial and non-spatial information. This work may produce new insights into the neural basis of memory beyond spatial cognition, as the same neural systems that underlie navigating and remembering spatial environments are also thought to be involved in non-spatial memory processes. We anticipate that our work will lead to new understanding and treatments for neurological disorders related to spatial disorientation or memory impairments.

PI_NAMEs: JACOBS, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Animals;Anterior;Behavior;Behavioral;Bilateral;Brain;cell type;Cells;Code;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;Complex;Computer Models;computerized;Decision Making;Disorientation;Environment;Epilepsy;Episodic memory;Event;Experimental Designs;experimental study;Geography;Goals;Hippocampus;Human;Human Activities;Imagery;Imagination;Individual;insight;Instruction;Knowledge;Laboratories;Learning;Life;Location;Maps;Measures;medial temporal lobe;member;Memory;memory encoding;Memory impairment;memory process;memory retrieval;Nervous System Disorder;neural;neural correlate;Neurons;Neurosciences Research;neurosurgery;neurotransmission;novel;Outcome;Patients;Pattern;Persons;Phase;Population;Positioning Attribute;Process;Property;remote location;Reporting;Research;response;Rewards;Rodent;Role;sensory input;sequence learning;spatial memory;Structure;support network;System;Testing;theories;Time;time use;virtual reality;way finding;Work

PROJECT_TITLE: The Role of Place and Grid Cells in Human Spatial and Non Spatial Memory

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Cachexia;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE: PROJECT 3 Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with staggering statistic, with ~8% of patients surviving five years after their initial diagnosis, and PDAC patients are especially prone to cachexia, a syndrome characterized by pronounced weight loss due to depleting skeletal muscle and adipose tissues that contributes to mortality in this disease. One hallmark of PDAC is the dense stroma consisting of activated cancer fibroblasts that surround each tumor, however, the role of these l cells in supporting tumor growth and cancer cachexia is controversial, and major gaps in knowledge exist regarding their contribution to cancer progression and cachexia. In this project, we propose to determine the function of the IL6/STAT3 signaling pathway, a pathway that could be targeted with existing drugs, in the communication between the stroma in the tumor and in peripheral tissues affected in cachexia.

PI_NAMEs: OSTROWSKI, MICHAEL C. (contact)

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Affect;angiogenesis;Antibodies;Body Weight decreased;Cachexia;Cancer Cachexia;Cell Nucleus;Cells;chemotherapy;Communication;CXCL1 gene;cytokine;Development;Diagnosis;Disease;effective therapy;Extracellular Matrix;Fatigue;Fatty acid glycerol esters;Fibroblasts;Flow Cytometry;gemcitabine;Gene Deletion;Genetic;Homeostasis;Human;IL6 gene;Immune;immune cell infiltrate;Interleukin-6;Knowledge;L Cells;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mesenchymal;mesenchymal stromal cell;Modeling;mortality;mouse model;Muscle;muscle progenitor cell;Muscular Atrophy;Natural regeneration;neoplastic cell;NF-kappa B;Operative Surgical Procedures;Paclitaxel;pancreas development;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;programs;Radiation therapy;Reaction;recruit;Role;Sampling;selective attention;Seminal;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Solid Neoplasm;spectrograph;STAT3 gene;Stat3 Signaling Pathway;statistics;Survival Rate;Syndrome;synergism;System;targeted treatment;Testing;Tissues;tocilizumab;transcriptome;transcriptome sequencing;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;wasting;Wasting Syndrome

PROJECT_TITLE: Project 3 – Stromal derived IL-6/STAT3 signaling in the development and progression of PDAC


PHR: PROJECT NARRATIVE – DEVELOPMENTAL CORE The overarching goal of the Developmental Core (DC) for the P artnership to A ssess V iral and Immune L andscape Intersections with On cology for People Living with HIV (PAVILION) is to enhance capacity for HIV- associated cancer research through fostering the career development of junior investigators in South Africa, Zimbabwe, and the United States who have a demonstrated interest in infection-related cancer research among people living with HIV (PLWH). This goal involves two broad strategies: 1) implementing a program that generates and supports rigorous pilot research projects and 2) providing other training and educational resources to enhance skills necessary for long term career success, which represents a shift in the culture of research at PAVILION partnering low- and middle-income country (LMIC) institutions. The momentum created by this strategy would provide significant incentive for junior investigators at these sites to take advantage of pilot research funding opportunities while consolidating efforts to pursue career development within a supportive environment with highly experienced mentors, ensuring their long-term success as independent researchers that will meet the critical need for transdisciplinary, multi-institutional, and international partnerships to understand and potentially mitigate the rapidly growing cancer burden in Africa, where the prevalence of HIV infection remains high.

PROJECT_TERMS: Africa;African;AIDS related cancer;anti-cancer research;Area;Award;Cancer Burden;cancer education;career;career development;Country;course development;design;Development;Discipline;Education;education research;education resources;Educational workshop;Ensure;experience;Fostering;Funding;Funding Opportunities;Germany;Goals;Grant;HIV;HIV Infections;Immune;improved;Incentives;infection related cancer;innovation;Institution;interest;International;international partnership;Journals;Knowledge;Lead;lectures;low and middle-income countries;Malignant Neoplasms;Measures;meetings;Mentors;Oncology;Outcome;Outcome Measure;Peer Review;Persons;Prevalence;Prevention;Process;Process Measure;programs;protocol development;Public Health;Publications;Questionnaires;Research;Research Personnel;Research Project Grants;Scientist;Senior Scientist;Site;skills;South Africa;success;supportive environment;Training;Training Activity;Training and Education;United States;Viral;virtual platform;Zimbabwe

PROJECT_TITLE: Developmental & Career Enhancement Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Our research centers on the essential processes coordinating the environment with cell growth and cell cycle progression in bacteria. Environmental variables dictate not only metabolic status and growth rate, but also morphology, development, and antibiotic sensitivity. Illuminating the regulatory circuits governing the relationship between the environment and bacterial physiology is essential to understand their contribution to antibiotic resistance and to assist in the design and development of approaches to defeat this problem.

PI_NAMEs: LEVIN, PETRA ANNE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial;Bacteria;Bacterial Physiology;Behavior;beta-Lactam Resistance;beta-Lactams;Biochemistry;Biogenesis;biological adaptation to stress;Biology;Cell Cycle Progression;Cell division;cell envelope;Cell Wall;Cells;Cellular Morphology;Cessation of life;crosslink;Cytoplasm;Defect;design;Development;drug resistant pathogen;Ensure;Environment;Enzymes;Escherichia coli;Exposure to;Gammaproteobacteria;Growth;Impairment;In Situ;Individual;interdisciplinary approach;interest;Klebsiella pneumoniae;Life;Lipopolysaccharides;Mediating;Membrane;Metabolic;Metabolism;Mitotic Cell Cycle;model organism;Morphology;Motivation;novel strategies;novel therapeutics;Nutrient availability;Organism;pathogen;pathogenic bacteria;Peptidoglycan;Peptidyltransferase;Permeability;Physical condensation;Physiology;Play;preservation;pressure;Prevalence;Process;Reagent;Regulation;Research;resistant Klebsiella pneumoniae;Role;single molecule;Starvation;Techniques;Trees;Work

PROJECT_TITLE: Environmental regulation of bacterial growth and cell division

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Poverty is an important contributor to poor short- and long-term HIV outcomes for pregnant people with HIV (PrPWH), and recent evidence suggests that part of poverty's negative effects on health outcomes are mediated by a reduction in mental bandwidth, an effect which may be magnified during pregnancy and the postpartum period. In this proposal set in Fond-des-Blancs, Haiti, I will characterize the relationship between mental bandwidth, HIV, and the perinatal period in an impoverished rural population, use a qualitative study to identify key characteristics of an unconditional cash transfer intervention for PrPWH with a goal of improving mental bandwidth, and assess this intervention using a Hybrid Type 2 effectiveness-implementation trial. This research is of high public health relevance because additional strategies are urgently needed to improve short- and long-term virological outcomes for this high priority population in order to prevent disease progression, development of drug resistance, transmission to partners, and perinatal transmission during current and future pregnancies.

PI_NAMEs: RICHTERMAN, AARON G (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Affect;antenatal care;antiretroviral therapy;Attention;Behavior;behavioral economics;Biometry;Birth;Breast Feeding;caregiving;Caring;Characteristics;Clinic;Clinical;clinical trial implementation;Cohort Studies;combat;Communicable Diseases;Communities;Consolidated Framework for Implementation Research;Consumption;Country;Cross-Sectional Studies;data integration;Decision Making;design;Disease Progression;drug resistance development;economic need;Economics;effectiveness/implementation hybrid;effectiveness/implementation trial;Ensure;experience;Food;food security;Frequencies;Future;Goals;Haiti;Haitian;Health;Health behavior;Health behavior and outcomes;Health Personnel;Health Priorities;Health Promotion;HIV;Hospitals;Hybrids;implementation outcomes;implementation science;improved;improved outcome;Incentives;indexing;Individual;innovation;Intelligence;interest;Intervention;intervention effect;Intervention Trial;Interview;Liquid substance;Low income;Master of Public Health;Measurement;Measures;Mediating;Medical;meetings;Mental Depression;Mentors;Methods;Mother-to-child HIV transmission;Outcome;Pathway interactions;payment;Pennsylvania;perinatal period;Perinatal transmission;Persons;Physicians;poor health outcome;Population;Postpartum Period;Poverty;poverty alleviation;Pregnancy;pregnant;prevent;Prevention;primary outcome;Process;programs;prototype;Psyche structure;psychologic;Psychological Impact;public health relevance;Publishing;Randomized;Research;Resources;Rural;Rural Population;Sampling;Scientist;Services;social;Social support;Structure;Subgroup;Surveys;Taxes;Testing;theories;therapy adherence;therapy outcome;Training;transmission process;Universities;Viral;Work

PROJECT_TITLE: Poverty, Mental Bandwidth, and an Unconditional Cash Transfer Intervention to Enable Health Behaviors for Pregnant People with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative This proposal focuses on nebulin, a skeletal muscle protein that causes the debilitating nemaline myopathy disease, NEM2. Using innovative research directions and novel tools we will investigate the nebulin/Lmod2 dual regulation model of thin filament length regulation, the significance of weak actin-binding super-repeats in nebulin, and the role of the C-terminus of nebulin in the Z-disk structure and function. We will also investigate novel avenues for restoring force generation in NEM2.

PI_NAMEs: GRANZIER, HENK L. (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Address;Affinity;Alternative Splicing;Basic Science;Binding;Binding Proteins;Biological Assay;Biology;Biomechanics;Collaborations;congenital myopathy;differential expression;Disease;Distal;effective therapy;Environment;experience;Fiber;filamin;Generations;Goals;innovation;insight;interdisciplinary approach;Kinetics;Length;Location;Mechanics;Microfilaments;Missense Mutation;Modeling;mouse model;Muscle;Muscle function;Muscle Proteins;muscular structure;Mutation;Myopathy;nebulin;Nemaline Myopathies;novel;novel therapeutic intervention;novel therapeutics;Patients;Play;Productivity;protein structure;Proteins;Proteomics;Publishing;Regulation;Research;RNA Splicing;Role;Scientist;Severity of illness;single molecule;Skeletal Muscle;Striated Muscles;Structure;superresolution imaging;Talents;Testing;Thick Filament;Thin Filament;Thinness;tool;transcriptomics;translational goal;translational potential;translational study;ultra high resolution;Width;Work;X ray diffraction analysis

PROJECT_TITLE: Roles of Nebulin in Structure and Function of Striated Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

PHR: ADMINISTRATIVE CORE: NARRATIVE SPOREs are multi-faceted and complex research programs with many “moving parts”. The Administrative Core will provide structure and organization to ensure integration and to see that synergy is achieved as a result of interactions between the many parts of this SPORE, and by facilitating Northwestern Brain Tumor SPORE interactions with other NCI-supported programs of research.

PROJECT_TERMS: Accounting;Administrator;Advocacy;Advocate;Brain Neoplasms;Cancer Center;Clinical Research;Collaborations;Complex;Comprehensive Cancer Center;Contracts;Ensure;Evaluation;Funding;Grant;Individual;Industry;innovation;Institution;Investigation;Investigational Therapies;Leadership;Malignant neoplasm of brain;medical schools;meetings;Patient advocacy;Patients;pre-clinical;Procedures;Productivity;programs;Qualifying;Recommendation;Reproduction spores;Research;Research Personnel;Robin bird;Structure;synergism;translational approach;Translational Research;Treatment outcome;Tumor Biology

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: U19 Program Narrative The proposed studies will explore the hypothesis that activation of neurons increases transport of cerebrospinal fluid (CSF) in the perivascular spaces and in the ventricles via neurovascular coupling-mediated arterial dilation. We hypothesize that the transient changes in blood volume, that are most pronounced during sleep, act as a driving force for reciprocal transport of CSF. Studies linking neural activity, blood and CSF transport in the mouse and human brain will use an array of imaging approaches across multiple temporal and spatial scales, and will be unified in a computational fluid flow model.

PI_NAMEs: DREW, PATRICK JAMES;HIRASE, HAJIME ;KELLEY, DOUGLAS H;LEWIS, LAURA DIANE;NEDERGAARD, MAIKEN  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Advisory Committees;Affect;Arousal;Arteries;Astrocytes;Automobile Driving;basal forebrain;Biological;Blood;Blood Vessels;Blood Volume;Brain;Cell Nucleus;cell type;Cells;Cephalic;Cerebrospinal Fluid;cerebrospinal fluid flow;Collaborations;Compensation;Coupled;Cyclic AMP;Data Science;designer receptors exclusively activated by designer drugs;Dimensions;driving force;Elements;Event;Excision;experimental study;Fiber;fluid flow;G-Protein-Coupled Receptors;genetic manipulation;glymphatic clearance;glymphatic system;hemodynamics;Human;Hyperemia;Image;imaging approach;Individual;Kinetics;Length;Link;Liquid substance;locus ceruleus structure;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mediating;Metabolic;Microspheres;Modeling;Monitor;Movement;Mus;network models;neural;neural circuit;neural patterning;neuromechanism;neuronal circuitry;Neurons;neuroregulation;neurovascular;neurovascular coupling;neurovascular unit;non rapid eye movement;novel;Opsin;optical imaging;Optics;optogenetics;particle;Photometry;Population;Production;programs;Property;Pump;response;Rodent;Role;Sensory;Shapes;Signal Transduction;simulation;Sleep;Smooth Muscle Myocytes;solute;spatiotemporal;Subarachnoid Space;Techniques;Testing;tool;transmission process;Transport Process;two photon microscopy;Variant;Vibrissae;Viral;Wakefulness;wasting;Work

PROJECT_TITLE: Neural circuit control of fluid and solute clearance during sleep


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE: CORE A The Administrative Core is essential to facilitate efficient and effective functioning of all components of this Program Project. Together, the several program components linked through the Administrative Core serve as an engine for discovery in the three separate but integrated cancer cachexia signaling pathways and for translating these basic discoveries into novel therapies for the treatment of this debilitating condition.

PROJECT_TITLE: Core A - Administration


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE DEPT/FOOD/AGRICULTURE

PHR: California Department of Food and Agriculture PAR-21-174  Project Period: 2021-2026 Project Narrative The main goal of the proposed project is to further develop, enhance, and sustain the California Food Safety Program to full conformance with the U.S. Food and Drug Administration’s (FDA) Food Safety Modernization Act, Standards for the Growing, Harvesting, Packing, & Holding of Produce for Human Consumption (Produce Safety Rule) through short and long-term interagency collaborations; and continued extensive cooperation and coordination with the FDA, other state and local agencies, and industry. These activities are intended to further enhance the State’s Produce Safety Program and its ability to reduce, prevent, and respond to food emergencies and better align it with a national integrated food safety system. Achieving the goal will better protect and improve the health of the public by assuring that food is produced safely and unadulterated.

PI_NAMEs: JOSHI, GEETIKA  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path B CDFA Continuation and Enhancement of the Produce Safety Program


ORG_CITY: ANNAPOLIS

ORG_NAME: MARYLAND STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: MD

PHR: Project Narrative The Maryland Department of Agriculture project entitled “Maryland Department of Agriculture Path C Produce Safety Program” will build on and enhance the Maryland Produce Safety program, developed during the previous five years, to create a regulatory program focused on quality and national consistency. The project will provide outreach, education, technical assistance, regulatory oversight, and produce related event response through a produce safety program that fully integrates federal, state, local, and other partner resources to protect public health, enhance produce safety and achieve high rates of compliance with the Food Safety Modernization Act Produce Safety Rule.

PI_NAMEs: GILLINGHAM, MOLLY  (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path C Maryland Department of Agriculture Produce Safety Program


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Kidney disease is more common in African Americans and is linked to genetic variants in the gene APOL1. These studies will determine the normal function of APOL1 and how it is different with the disease variants, to advance the development of new therapies to treat kidney diseases impacted by APOL1 genotype.

PI_NAMEs: BRUGGEMAN, LESLIE A (contact);O'TOOLE, JOHN F.;SEDOR, JOHN R.

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: adaptive immune response;Advanced Development;Advocate;African American population;AIDS-Associated Nephropathy;Alleles;Apolipoproteins;Attenuated;Bacterial Artificial Chromosomes;Biochemical;Biochemical Pathway;biological adaptation to stress;Biological Models;Biological Process;Cell Adhesion;Cell Line;Cell Survival;Cells;Chronic Kidney Failure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cytotoxicity;Data;density;Development;Disease;disease model;disease stressor;disorder risk;Endosomes;Environment;environmental stressor;Event;Exposure to;Focal and Segmental Glomerulosclerosis;Functional disorder;Future;gain of function;gene environment interaction;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Risk;Genetic Transcription;genetic variant;Genotype;Goals;Heterozygote;high risk;HIV;HIV Infections;Human;Hypertension;Immune;immune activation;Immune response;Immune signaling;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Inheritance Patterns;Inherited;Injections;Injury;innate immune pathways;Interferons;Investigation;IRF3 gene;Kidney;kidney biopsy;Kidney Diseases;Knock-out;Link;loss of function;Lupus Nephritis;Mediating;Methods;Modeling;mouse model;Mus;non-diabetic;novel;novel therapeutics;Outcome Study;Pathogenesis;Pathogenicity;Pathology;Pattern recognition receptor;Phenotype;podocyte;Prevalence;Prevention strategy;Process;protective effect;racial health disparity;Receptor Activation;recessive genetic trait;Renal function;response;Risk;risk variant;Role;Signal Transduction;Stimulus;Stress;stressor;targeted treatment;Testing;therapy design;Time;TLR3 gene;Toll-like receptors;trafficking;trait;Transgenic Mice;treatment strategy;United States;Variant;Vesicle;Virus;Virus Diseases;Work

PROJECT_TITLE: Intracellular functions of APOL1 in the kidney

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(03)]


NIH_SPENDING_CATS: Cachexia;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE: CORE B This program will define molecular and cellular interactions between immune system modulators and different cell and tissue types in the development and progression of pancreatic cancer and in the accompanying systemic wasting syndrome known as cachexia. This Core resource will collect and provide human tissue samples from and disease-related data from consenting patients with pancreatic cancer and perform isolation of cells and nuclei from tumor, blood, adipose and muscle in order to carry out advanced gene expression analysis from individual cells. The functions of this Core will benefit all projects.

PI_NAMEs: KONIARIS, LEONIDAS G. (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Automobile Driving;Benign;Biometry;Blood;Body Weight decreased;Cachexia;Cancer Cachexia;Cell Nucleus;Cell Separation;Cells;Clinical;Clinical Data;clinical translation;Comprehensive Cancer Center;Consent;Data;Dedications;Development;Diagnosis;Disease;DNA Sequencing Facility;effective therapy;Ensure;Exhibits;Fibroblasts;Gene Expression;Gene Expression Profiling;Goals;Histologic;Human;human data;human tissue;Immune system;improved;Indiana;Individual;Infrastructure;Interleukin-6;Knowledge;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscular Atrophy;neoplastic cell;NF-kappa B;novel;Operative Surgical Procedures;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathology;Patients;Peripheral;Phenotype;Preparation;preservation;Process;programs;Protocols documentation;Quality of life;receptor;Reporting;Research;Research Personnel;Resolution;Resources;Role;sample collection;Sampling;Sequence Analysis;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;Specimen;STAT3 gene;success;Technology;Testing;Tissue Sample;Tissues;transcriptome sequencing;transcriptomic profiling;translational potential;treatment response;Treatment-related toxicity;tumor;Tumor Biology;tumor microenvironment;Tumor Promotion;Universities;wasting;Wasting Syndrome;Work

PROJECT_TITLE: Core B – Human Biospecimen and Advanced Sequencing Core


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT 1: PROJECT NARRATIVE  One of the major limitations of oncolytic virotherapy (OV) is poor intratumoral distribution. To overcome this problem our group has demonstrated that neural stem cells (NSCs) can be used as a cell carrier to enhance the delivery of a novel oncolytic adenovirus and increase the therapeutic efficacy of such combined strategy vs. local delivery of the virus alone. In this continued renewal, we focus on establishing the safety of repeat product administration utilizing a novel and implantable based catheter system, examine tumor microenvironment after product administration, and validate previously identified genes implicated in OV susceptibility as a biomarker for patient selection in a larger phase 2 clinical trial.

PROJECT_TERMS: Address;Amides;anti-tumor immune response;Biological Markers;Biological Models;Biopsy;Brain;Candidate Disease Gene;Carrier Proteins;Catheters;Cell Nucleus;Cell Survival;Cells;Clinical Protocols;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;conditionally replicative adenovirus;CRISPR screen;design;Distant;Drug Delivery Systems;Excision;Funding;Future;Gene Expression;Genes;Glioblastoma;Glioma;Heterogeneity;Human;Immune response;Immunofluorescence Immunologic;Implant;In Vitro;in vivo Model;Industry;Infection;Infiltration;Injection product;Injections;interest;Investigation;Knock-out;Macrophage;Malignant Glioma;Malignant neoplasm of brain;Maximum Tolerated Dose;Methods;migration;molecular targeted therapies;N-Acetylcysteinamide;Neoadjuvant Therapy;neoplastic cell;nerve stem cell;Newly Diagnosed;novel;nucleocytoplasmic transport;Oncology;oncolytic adenovirus;oncolytic virotherapy;Oncolytic viruses;Outpatients;Overlapping Genes;particle;patient biomarkers;Patient Selection;patient stratification;patient subsets;Patients;Pharmacologic Substance;Phase;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Phenotype;predictive marker;Predisposition;Production;programs;Publishing;Recurrence;resilience;Safety;safety and feasibility;Sampling;Signal Transduction;single-cell RNA sequencing;Specimen;stem cells;Susceptibility Gene;System;targeted treatment;Testing;therapeutic effectiveness;therapeutic evaluation;Time;Tissues;transcriptomics;translational approach;Treatment Efficacy;treatment optimization;tumor;tumor microenvironment;Tumor Tissue;Viral;Virotherapy;Virus;Virus Replication

PROJECT_TITLE: Neural Stem Cell Based Virotherapy for Malignant Glioma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: DERMATOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  Acne significantly impairs quality of life and is associated with higher risks of mental health disorders. Little is known about how internal and external hormones interact on the burden and outcomes of acne, particularly for transgender persons requiring long-term hormone treatment. This proposal aims to identify and better understand the burden, experience, and outcomes of acne with the ultimate goal to improve skin, mental health, and quality of life outcomes from acne and hormone treatments.

PI_NAMEs: YEUNG, HOWA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acne;Address;Adult;Adverse effects;Age;Androgens;Anti-androgen Therapy;Area;Arthritis;Asthma;Benefits and Risks;Birth;career;Caring;Characteristics;Chronic Disease;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials;cohort;Collection;community engaged research;comorbidity;cost;Cutaneous;Data;Data Collection;design;Development;Diabetes Mellitus;Diagnosis;disability burden;Disparity;disparity reduction;Epidemiology;experience;Feeling suicidal;Feminization;Funding;Future;future implementation;Gender;gender affirming hormone therapy;gender dysphoria;Gender Identity;gender minority group;gender minority health;gender minority health disparity;Goals;Health;health care disparity;health care settings;Health Disparities Research;health disparity populations;health related quality of life;Health Status;Healthcare Systems;High Prevalence;high risk;Hormonal;hormone therapy;Hormone use;Hormones;Impaired health;Impairment;improved;Incidence;Individual;interest;Intervention;Interview;Knowledge;Measures;Mediating;Mediator;Melanoma;men;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Methods;minority disparity;minority health;minority stress;Modeling;Multicenter Studies;multidisciplinary;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;Natural History;Oral Contraceptives;Outcome;Outcomes Research;Pathogenesis;patient oriented;Patient Recruitments;Patient-Focused Outcomes;Patients;Persons;pilot test;Population;Prevalence;Prospective Studies;Prospective, cohort study;Protocols documentation;Psoriasis;Quality of life;Race;recruit;Research;Research Methodology;Research Personnel;Research Technics;Research Training;Retrospective Studies;self esteem;Severities;sex;Sexual and Gender Minorities;sexual minority group;sexual minority health;Site;Skin;Skin Carcinoma;skin disorder;social;Surveys;Techniques;Testosterone;theories;Training;transfeminine;transgender;transmasculine;Well in self;Women's study

PROJECT_TITLE: Epidemiology, impact, and experience of acne in transgender persons

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_NAME: GEORGIA STATE DEPARTMENT OF AGRICULTURE

PHR: Overall Component: Project Narrative Project Period: July 1, 2020 – June 30, 2025 Project Narrative Georgia Department of Agriculture (GDA) will continue to strive toward full compliance with the Manufactured Food Regulatory Program Standards (MFRPS) and Animal Feed Regulatory Program Standards (AFRPS) by building capacity in an integrated food safety program consisting of combined contributions from state, local, and federal collaborators. This project will ensure that samples are analyzed by primary servicing laboratories using quality systems to give regulatory partners assurance in in test results and their enforcement response. This grant will leverage state resources and capabilities to further advance the Food Safety Modernization Act and an Integrated Food Safety System

PI_NAMEs: CRABTREE, CARRIE  (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Georgia Department of Agriculture's Laboratory Flexible Funding Model project


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, and high blood pressure is a leading contributor to cardiovascular diseases. Although the causes of high blood pressure are varied, many forms are characterized by increased levels of sympathetic nerve activity, and the reasons for this increased sympathetic activity are generally unknown. This project seeks to define the role that the sensory nerves of the kidneys play in increasing sympathetic nervous system activity and thereby increasing cardiovascular disease.

PI_NAMEs: BECKER, BRYAN K (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adenosine;Affect;afferent nerve;Afferent Neurons;Angiotensin II;Animals;Applications Grants;autonomic nerve;Blood Pressure;Cardiovascular Diseases;Chemicals;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;Conscious;Data;Denervation;desensitization;Development;Devices;diet-induced obesity;dietary;Disease;Electrophysiology (science);Endothelin;Endothelin A Receptor;Endothelin B Receptor;Endothelin-1;Equilibrium;experience;experimental study;Fatty acid glycerol esters;Foundations;Functional disorder;Future;Goals;hemodynamics;High Fat Diet;high salt diet;Hypertension;hypertension treatment;Image;In Vitro;instrument;Intervention;Kidney;kidney vascular structure;Label;Mechanics;Mediating;Mentors;Modeling;Morbidity - disease rate;mortality;Natriuresis;Nerve;Neurons;novel;patch clamp;Pathway interactions;Peptides;pharmacologic;Physiology;Play;Population;Population Heterogeneity;Rattus;receptor;Receptor Activation;receptor expression;Receptor Signaling;Reflex action;Renal pelvis;Reporting;Research Proposals;research study;response;Rodent Model;Role;salt sensitive;salt sensitive hypertension;Sensory;Sodium;Sodium Chloride;Spinal Ganglia;Stimulus;Stretching;success;Sympathetic Nervous System;System;targeted delivery;Technical Expertise;Techniques;Testing;Therapeutic Intervention;therapeutic target;Training;Tubular formation;Uncertainty;Water;western diet

PROJECT_TITLE: Renal Sensory Nerve Contribution to Hypertension


NIH_SPENDING_CATS: Biotechnology;Cachexia;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Rare Diseases

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE: CORE C  The central goal of this Immunophenotyping Core is to provide the research projects in this Program Project  state-of-art technologies in the fields of genomics and histology to advance our understanding of how NF-κB,  STAT3 and IL-6 function together to control the macroenvironment of pancreatic cancer -induced cachexia.

PI_NAMEs: ROMEO, MARTIN JOHN (contact)

PROJECT_TERMS: Adipose tissue;Advanced Malignant Neoplasm;Affect;Animal Model;Architecture;Biological Assay;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;Catabolism;Cell Survival;cell type;Cells;cytokine;Data;Data Analyses;deep learning;Diagnosis;Disease;fat wasting;Fatigue;Fatty acid glycerol esters;Gene Expression;genetic manipulation;Genomics;Goals;histological studies;Histology;Image;Imaging Techniques;Immune;immune imaging;Immunofluorescence Immunologic;Immunophenotyping;improved;Incidence;Indiana;Inflammatory;Interleukin-6;Libraries;machine learning algorithm;Malignant neoplasm of pancreas;Medical;Molecular;Morbidity - disease rate;mortality;mouse model;multiplexed imaging;Mus;Muscle;Muscular Atrophy;Nature;novel therapeutics;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway Analysis;Pathway interactions;Patients;Population;Prognosis;Program Research Project Grants;programs;Quality of life;recruit;Research;Research Project Grants;Role;Sampling;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Skeletal Muscle;skeletal tissue;South Carolina;spectrograph;STAT3 gene;Syndrome;Techniques;Technology;Time;Tissues;transcription factor;transcriptome sequencing;tumor;tumor microenvironment;tumor progression;Tumor Tissue;Universities;user-friendly;wasting;Wasting Syndrome;Weight

PROJECT_TITLE: Core C – Immunophenotyping Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BROOKINGS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: Project Narrative This goal of this application is to enhance the diagnostic capacity and capabilities of Animal Disease Research and Diagnostic Laboratory (ADRDL), South Dakota in support of an integrated food safety system. Specifically, enhancements in microbiology food defense, whole genome sequencing based testing and data exchange is envisaged.

PI_NAMEs: RUESCH, LAURA  (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Preventing foodborne illnesses by improving integrated food safety system


ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

ORG_STATE: MN

PHR: PROJECT NARRATIVE The MDA Laboratory Services Division will work with the MDA and the FDA to enhance the capacity and capabilities of state human and animal food testing laboratories in support of an integrated food safety system. Our work will support the goal to strengthen and improve collaboration of surveillance testing activities between the FDA and state laboratory partners to continue building a nationally integrated laboratory science system. The MDA laboratory will help meet this goal by providing the FDA the data necessary to help identify and address hazards in human and animal food products. Through the sharing of high-quality, defensible laboratory results, early identification and regulatory response to adulterants in food will be promoted. Project Narrative - Minnesota Department of Agriculture

PI_NAMEs: BINDERT, BRYANNE  (contact)

PROJECT_TITLE: Laboratory Flexible Funding Model- Minnesota Department of Agriculture


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT 2: NARRATIVE Reprogramming of the predominant immune-suppressive tumor environment may allow for immunological clearance of glioblastoma. In the first-in-man phase I clinical trial, a STING agonist is administered directly to the glioblastoma microenvironment. Target engagement is evaluated as a function of baseline myeloid infiltration, STING promoter methylation status, tumor immune functional assessments, and [18F]FLT tumor uptake.

PI_NAMEs: HEIMBERGER, AMY BETH (contact)

PROJECT_TERMS: Address;Aftercare;Agonist;biomarker selection;Biopsy;Canis familiaris;Catheters;CD14 gene;Cells;Cellular Stress;Cellular Structures;Characteristics;chemokine;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Conduct Clinical Trials;contrast enhanced;Core Biopsy;CXCL10 gene;cytokine;Cytometry;Cytoplasm;Cytotoxic T-Lymphocytes;Data;design;Diameter;digital;Dinucleoside Phosphates;DNA;Dose;effector T cell;efficacy evaluation;Environment;Evaluable Disease;first-in-human;Flow Cytometry;Gene Activation;Gene Targeting;gene-targeted therapy;Genes;Glioblastoma;Glioma;Goals;Growth;Human;humanized mouse;Hypermethylation;Image;Immune;immune checkpoint;Immune checkpoint inhibitor;immune clearance;Immune response;Immunofluorescence Immunologic;Immunologics;Implant;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Injections;interest;Interferons;IRF3 gene;Kinetics;Macrophage;Malignant neoplasm of brain;Maximum Tolerated Dose;Mediating;Metabolism;Methylation;MGMT gene;Microdialysis;Modeling;Molecular;monocyte;Myelogenous;Myeloid Cells;nano-string;Natural Immunity;neoplastic cell;Newly Diagnosed;NF-kappa B;Nucleosides;Operative Surgical Procedures;Outcome;Pathway interactions;Patient imaging;patient subsets;Patients;Periodicity;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;Phenotype;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;predictive marker;Production;programs;promoter;Radiation;Radiation therapy;radiological imaging;Recurrence;Recurrent tumor;Resectable;Resected;Resistance;response;Sampling;sensor;Signal Transduction;standard of care;Stimulator of Interferon Genes;synergism;T cell infiltration;T-Lymphocyte;temozolomide;Testing;Therapeutic;Thymidine;Thymidine Phosphorylase;Time;tissue culture;Tracer;trafficking;transcriptome sequencing;translational approach;Treatment Efficacy;tumor;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;uptake

PROJECT_TITLE: STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBM


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Psychosis;Rare Diseases;Schizophrenia;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Schizophrenia (SCZ) is a disabling neurodevelopmental disorder that generally emerges in adolescence or young adulthood due to the confluence of genetic and environmental risk factors. There is a critical need to characterize biological pathways underlying the development of SCZ and other neuropsychiatric disorders. Using longitudinal neuroimaging and spatial transcriptomics, this project aims to elucidate brain biomarkers and neurobiological mechanisms related to genetic and clinical risk factors for psychosis spectrum disorders.

PI_NAMEs: SCHLEIFER, CHARLES  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Adolescence;Adult;Age;age related;American;Anxiety Disorders;Atlases;Attentional deficit;autism spectrum disorder;Autopsy;Behavior;Behavioral;Biological;Biological Markers;blood oxygen level dependent;Brain;brain based;Brain region;brain tissue;California;cell type;Chromosome 22;Clinical;clinical high risk for psychosis;clinical risk;Code;cohort;Communication;Complex;Copy Number Polymorphism;Data;Data Analyses;Data Set;Development;Diagnosis;DiGeorge Syndrome;Disabling;Disabling condition;Disease;Educational workshop;Environment;Environmental Risk Factor;excitatory neuron;Exhibits;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic association;Genetic Diseases;Genetic Markers;Genetic Materials;Genetic Risk;genetic risk factor;Heritability;high risk;hippocampal pyramidal neuron;Hippocampus;Human;imaging genetics;indexing;Individual;inhibitory neuron;Intellectual functioning disability;Interneurons;Location;longitudinal dataset;Longitudinal Studies;Los Angeles;Magnetic Resonance Imaging;Maps;Measures;Micro Array Data;Modeling;mouse model;multimodality;neural;neurobiological mechanism;neurodevelopment;Neurodevelopmental Disorder;neurogenetics;neuroimaging;neuronal patterning;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;Parvalbumins;Pathway interactions;Patients;Pattern;Phenotype;Population;programs;Proteins;Psychoses;psychosis risk;Psychotic Disorders;Recurrence;Research;Rest;Risk;Risk Factors;Sampling;Schizophrenia;Science;Sensory;Severities;Signal Transduction;Site;Symptoms;Syndrome;System;Testing;Thalamic structure;Tissues;tool;Training;transcriptomics;translational model;Universities;Work;young adult;Youth

PROJECT_TITLE: Mapping functional brain connectivity, neurodevelopment, and imaging-genetic associations in individuals with genetic and clinical risk factors for neuropsychiatric illness


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Tough fibrous interfaces between tissues are a common location of injury and source of pathology, pain and disability. Surgical repairs of interfaces that are desirable proceed in the absence of knowledge of the mechanisms that endow fibrous interfaces with toughness, and unsurprisingly have very high failure rates of up to a nearly unbelievable 94%. By developing and testing the first mathematical models for the toughness of this class of interfaces, we hope to identify the mechanisms of toughening definitively, and more broadly to provide technology that enables design of improved surgical procedures.

PI_NAMEs: GENIN, GUY M (contact);THOMOPOULOS, STAVROS

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: absorption;Adhesions;Adhesives;Animal Model;Automobile Driving;behavior prediction;Biological Models;bone;bone repair;Bone Tissue;Botulinum Toxin Type A;Brain;Characteristics;Collagen;Collagen Diseases;Collagen Fiber;Connective Tissue;cranium;crosslink;design;disability;Disease;Endowment;Environment;experimental study;Failure;Fiber;Foundations;Friction;Hernia;improved;In Vitro;in vivo;Injury;Intra-abdominal;Knowledge;Laparotomy;Length;Ligaments;Location;Machine Learning;mathematical model;mechanical behavior;Mechanics;Meniscus structure of joint;Mesentery;millimeter;Minerals;Modeling;Modification;molecular dynamics;multi-scale modeling;Mus;Musculoskeletal;nano;nanocrystal;nanoscale;Nature;Nervous System;older patient;Operative Surgical Procedures;Pain;Paralysed;Pathologic;Pathology;Patients;Peritoneal;Physiological;Pia Mater;Process;repaired;Rotator Cuff;Running;Skin;Slide;Source;Specimen;Stress;Structure;Surface;System;Technology;Tendinopathy;Tendon structure;Testing;Tissue Sample;Tissues;treadmill;Work

PROJECT_TITLE: Multiscale models of fibrous interface mechanics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLESTON

PHR: PROJECT NARRATIVE: CORE D The Biostatistics Core provides centralized and state-of-the-art support to meet the data management and analytic needs of all Projects. Core personnel have the necessary expertise in statistics to optimize the quantitative demands of the aims outlined in each Project. All Projects are guaranteed access to a robust quantitative tool kit to support tailored pipelines for data processing, curation, analysis , and storage.

PI_NAMEs: LI, HONG  (contact)

PROJECT_TERMS: Acceleration;Address;Basic Science;Biometry;Biostatistics Core;Biostatistics Shared Resource;Cancer Cachexia;Cancer Center;Collaborations;Communication;Complex;complex data;computerized data processing;Data;Data Analyses;data analysis pipeline;Data Analytics;Data Collection;Data Display;data exchange;data exploration;data integration;data management;data quality;data sharing;design;Ensure;Evaluation Research;Experimental Designs;experimental study;Faculty;Fertilization;Formulation;Fostering;Generations;Human Resources;Investigation;Maintenance;Malignant neoplasm of pancreas;Manuscripts;Medical;member;novel;Oncology;Outcome;Output;Positioning Attribute;power analysis;Preparation;Procedures;Program Research Project Grants;programs;Publications;Reporting;repository;Research;Research Design;Research Personnel;Resources;Role;Sample Size;Security;Services;skills;South Carolina;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;success;Testing;tool;Translational Research;Universities;Visual

PROJECT_TITLE: Core D – Biostatistics Core


NIH_SPENDING_CATS: Hematology;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Prolonged use of antibiotics impairs normal blood production by depleting the microbiome. Here, we propose to investigate the effects of prolonged antibiotics on hematopoietic progenitors and granulocyte populations and identify the microbiome-driven immune signaling pathways and metabolites that promote normal hematopoiesis.

PI_NAMEs: MAKNOJIA, ARUSHANA AMIR (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adverse effects;Agonist;Ampicillin;Anemia;Antibiotics;Biological Assay;Blood;Bone Marrow;Bone Marrow Suppression;Bromodeoxyuridine;Caspase Inhibitor;Cell Wall;Cessation of life;Clinical;Communication;Cyclic GMP;cytopenia;Defect;Distant;Feces;Fluorochrome;Genes;Germ-Free;granulocyte;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Immune;Immune signaling;Impairment;in vivo;Individual;Infection;Interferon Suppression;Interferon Type I;Interferon-beta;Interferons;Label;Laboratory Finding;Left;Leukopenia;Maintenance;Measures;Mediating;Mediator;Medical Care Costs;metabolomics;Methylcellulose;Metronidazole;microbial;microbiome;microbiota;Mitochondria;Molecular;mortality;mouse model;Mus;Myelopoiesis;Neomycin;Neutropenia;new therapeutic target;Pathway interactions;Patients;Phenotype;Population;prevent;Production;progenitor;Proliferating;Propidium Diiodide;Public Health;Receptor Signaling;Regulation;Reporter;Risk Factors;Sampling;screening;Sepsis;Serum;Signal Pathway;Signal Transduction;Signaling Protein;Sorting;Stains;STAT1 gene;stem cell population;stool sample;Testing;Therapeutic Intervention;therapy development;TLR3 gene;Toll-Like Receptor Pathway;Toll-like receptors;Transplantation;Tretinoin;Vancomycin;Viral;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of Steady-State Hematopoiesis by Microbiota-Driven IFN-I Signaling


ORG_CITY: LITTLE ROCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Mitochondrial poration by the BCL-2 protein BAK initiates apoptosis yet it remains poorly characterized and controversial. We will redefine the mechanistic understanding of mitochondrial poration by delineating how BAK is activated, how it associates with and porates mitochondria, and how it is recognized and blocked by prosurvival BCL-2 proteins.

PI_NAMEs: MOLDOVEANU, TUDOR  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affinity;Apoptosis;Apoptotic;bak protein;BCL-2 Protein;BCL1 Oncogene;BCL2L1 gene;BH3 peptide;Binding;Biochemistry;Biophysics;Caspase;Cell Death;Cell Membrane Permeability;Cells;Cellular biology;Complex;cytochrome c;Data;Detergents;dimer;Dimerization;Disease;drug discovery;Drug Targeting;Engineering;Fright;Functional disorder;Health;Heart Mitochondria;Human;Impairment;In Vitro;innovation;insight;Kinetics;Length;Link;Lipid Binding;Lipids;Liposomes;Malignant Neoplasms;MCL1 gene;Mediating;Membrane;Micelles;Mitochondria;Mitochondrial Proteins;Modeling;Molecular Conformation;monomer;Mutagenesis;mutant;Mutate;Nature;NMR Spectroscopy;Outer Mitochondrial Membrane;Pathway interactions;Permeability;Phospholipids;Physiology;Process;Proteins;Publishing;reconstitution;Resolution;Shapes;Signal Transduction;Site;Stress;structural biology;Structure;Time;Validation

PROJECT_TITLE: Elucidating the structural basis of mitochondrial outer membrane permeabilization in apoptosis

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Skeletal muscle wasting and weakness are highly prevalent in many cancers, and particularly pancreatic cancer. Data from our lab has recently identified that the complement system is highly enriched in the skeletal muscle of people and mice with pancreatic cancer, and associates with the muscle wasting and weakness. In the current work we will investigate the various complement pathways, test targeted complement therapeutics, and explore the role of muscle specific complement activation in pancreatic cancer-induced muscle wasting and weakness.

PI_NAMEs: ATKINSON, CARL ;JUDGE, ANDREW ROBERT (contact)

PROJECT_TERMS: Address;Adenocarcinoma;Affect;Atrophic;Body Weight decreased;C3AR1 gene;Cachexia;Calcium;Cancer Cachexia;Cancer Patient;cancer surgery;cancer survival;cancer therapy;carcinogenesis;cell type;Cells;Chimeric Proteins;clinically relevant;Collagen;comparison control;Complement;Complement 3a;Complement 3d Receptors;Complement 5a;Complement Activation;complement deficiency;Complement Inactivators;Complement Membrane Attack Complex;complement pathway;complement system;conventional therapy;Data;Deposition;Development;Disease;Event;Fatty acid glycerol esters;Foundations;Functional disorder;Goals;Health;Homeostasis;immune cell infiltrate;Impairment;improved;Inflammation;Injections;insight;Knockout Mice;Knowledge;KPC model;Lectin;Leucocytic infiltrate;Link;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle regeneration;Muscle Weakness;Muscular Atrophy;Natural regeneration;novel;Nutritional Support;Opsonin;Pancreas;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Physical Function;preservation;prevent;Proteins;Proteomics;Quality of life;response;Role;single nucleus RNA-sequencing;Site;Skeletal Muscle;skeletal muscle wasting;Source;Stimulus;Syndrome;Testing;Therapeutic;therapeutically effective;therapy development;Tissues;Transcript;transcriptome sequencing;Translating;translational potential;treatment strategy;tumor;Tumor Burden;tumor progression;Work

PROJECT_TITLE: The Complement System and Cancer Cachexia


PI_NAMEs: NEDERGAARD, MAIKEN  (contact)

PROJECT_TERMS: Advisory Committees;Astrocytes;Award;Blood Vessels;Code;Collaborations;Communication;Communities;Core Facility;Data;Data Analyses;data infrastructure;Data Science;Data Science Core;data sharing;Data Storage and Retrieval;Databases;Decision Making;Development;Doctor of Philosophy;Ensure;Environment;experience;Faculty;Feedback;fluid flow;follow-up;Fostering;glymphatic system;Goals;Human;Individual;Institution;International;Intranet;Journals;Knowledge;Link;Liquid substance;meetings;member;Mission;Modeling;Monitor;Names;neural;neural circuit;neuroimaging;Neurosciences;neurovascular coupling;organizational structure;Participant;Policies;Procedures;Productivity;programs;Progress Reports;Protocols documentation;Publishing;Regulation;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Running;Science;Scientist;Site Visit;Sleep;solute;Structure;Time;tool;tool development;undergraduate student;United States National Institutes of Health;Viral;virtual;wasting;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

PI_NAMEs: KELLEY, DOUGLAS H (contact)

PROJECT_TERMS: Algorithms;Anatomy;Animals;Archives;Artificial Intelligence;artificial intelligence method;Attention;base;Blood Vessels;Blood Volume;Brain;Brain imaging;cerebrospinal fluid flow;Characteristics;Classification;Code;code development;Collaborations;computational platform;Computer software;Data;data access;Data Files;data infrastructure;Data Science;Data Science Core;Data Scientist;Data Set;data sharing;Data Storage and Retrieval;doctoral student;Electroencephalography;experience;experimental study;file format;Goals;hemodynamics;Human;Image;image processing;imaging Segmentation;improved;in vivo;Individual;Information Retrieval;Infrastructure;innovation;instrument;invention;Investigation;large datasets;Lead;Learning;Link;Liquid substance;machine learning algorithm;Magnetic Resonance Imaging;mathematical model;Measurement;Measures;member;Metadata;Methods;Modernization;multimodal data;multimodality;Mus;neural;neural circuit;neuroregulation;Noise;novel;open source;organizational structure;Participant;Pattern;Productivity;programs;Publications;Reading;Recording of previous events;Regional Anatomy;repository;Research;Resources;Running;Sampling;Scientist;searchable database;Shapes;signal processing;simulation;Sleep;Software Tools;solute;Sorting;statistical and machine learning;supercomputer;synergism;System;Time;tool;Training;two-photon;Uncertainty;Universities;user-friendly;Variant;Viral;Virus;Visualization;Work;Writing

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHICAGO

PHR: PROJECT 3: NARRATIVE Immunotherapy is a promising approach to treating cancer patients, yet its efficacy so far has been very limited in patients with high grade gliomas. Our work provides an opportunity to explore the B-cell-based vaccine (BVax) as immunotherapy. Our approach utilizes 4-1BBL+ B cells as a cellular platform to promote anti-tumor immunity. This innovative strategy utilizes inherent B-cell effector functions such as antigen presentation and subsequent T-cell activation (cellular immunity), and production of tumor-reactive antibodies (humoral immunity). The preclinical BVax proved to be highly efficient at eradication the tumor in mice. The proposed research project aims to take BVax from the bench and translate it to the clinic.

PI_NAMEs: LEE CHANG, CATALINA  (contact)

PROJECT_TERMS: Agonist;Animals;anti-PD-L1;Antibodies;Antigen Presentation;Antigens;Appearance;Autologous;B cell therapy;B-Cell Activation;B-Lymphocytes;Blood;cancer immunotherapeutics;Cancer Patient;Cancer Vaccines;CD8-Positive T-Lymphocytes;CD86 gene;Cell Therapy;Cells;Cellular Immunity;Cellular immunotherapy;Characteristics;Clinic;Clinical;Clinical Data;Combined Modality Therapy;Combined Vaccines;Computer Analysis;cost;Cross Presentation;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;design;Development;Dose;Effector Cell;Ensure;first-in-human;Flow Cytometry;Glioblastoma;Glioma;Humoral Immunities;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunoglobulins;Immunologics;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;innovation;Intervention;Journals;Left;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;Medicine;Memory;Metabolic;MHC Class I Genes;migration;Molecular;Mus;Mutation;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;Patients;PD-L1 blockade;Penetrance;Physiologic pulse;pre-clinical;pre-Investigational New Drug meeting;preclinical study;prevent;Production;Publishing;Quality of life;Radiation;Recommendation;Research;Research Project Grants;Research Proposals;Safety;secondary lymphoid organ;Specificity;T cell infiltration;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic vaccine;Time;TNFRSF5 gene;transcriptomics;Translating;translational approach;treatment response;tumor;Tumor Antigens;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Vaccine Production;vaccine trial;Vaccines;Work

PROJECT_TITLE: Development of a B Cell Based Vaccine for the Treatment of Newly Diagnosed Malignant Gliomas


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative We propose to serve as a NARMS retail food surveillance collaborating laboratory. As a participant, we will routinely recover and contribute target pathogens and indicator bacteria to the NARMS surveillance program and support other agencies in Ohio investigating foodborne disease outbreaks. As part of the national NARMS network of laboratories, we will contribute to improved public health through the prevention of foodborne disease and reduced zoonotic transmission of antimicrobial resistant bacteria.

PI_NAMEs: WITTUM, THOMAS E (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: NARMS Retail Food Surveillance in Ohio


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cerebrovascular;Gene Therapy;Genetics;Neurosciences;Sleep Research

PI_NAMEs: HIRASE, HAJIME  (contact)

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Affect;Albumins;Astrocytes;Biomedical Research;Biosensor;Blood;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;brain circulation;Brain imaging;Breeding;capillary bed;Capsid;cell type;Cells;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrovascular Circulation;cholinergic;Chronic;Complement;cost;CRISPR/Cas technology;Cyclic AMP;Data Science Core;Dependovirus;Dermatology;design;Documentation;Engineering;Ependymal Cell;experimental study;Genes;Genetic;genome editing;gliovascular;Goals;Hepatocyte;Human;Image;Imaging Device;imaging study;Immune response;in vivo;in vivo evaluation;Inflammation;Injections;innovation;Intercellular Fluid;interest;intravenous injection;Ischemia;Knock-in;Label;Liquid substance;Liver;Malignant Neoplasms;Measurement;Mediating;Methods;minimally invasive;Molecular;Nephrology;neural;neural circuit;Neuroglia;Neurons;neurotransmission;neurovascular unit;new technology;noradrenergic;novel;optical imaging;Optics;Peptide Signal Sequences;Pharmacogenetics;Physiologic Monitoring;Physiological;Plasma;Process;Production;programs;promoter;Proteins;Publications;Published Comment;receptor;recombinant viral vector;Recombinants;Reporting;Research;Resource Sharing;Resources;Rodent;Second Messenger Systems;serial imaging;Signal Transduction;Sleep;solute;Specificity;Structure of choroid plexus;Techniques;Technology;Test Result;Testing;Time;TNFSF5 gene;tool;tool development;Toxic effect;Tracer;Transfection;Transgenic Mice;Variant;vector;Viral;Viral Vector;Visualization;Visualization software

PROJECT_TITLE: Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectors


NIH_SPENDING_CATS: Biotechnology;Facioscapulohumeral Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative Facioscapulohumeral muscular dystrophy (FSHD) is among the most common forms of muscular dystrophy. FSHD is caused when toxic gene called DUX4 is turned “on” in muscle. We believe that therapies for FSHD should focus on eliminating DUX4. We have developed three strategies to accomplish this using gene therapy. In this study, we will test the ability of these approaches to treat muscular dystrophy in mice, and also determine their ability to avoid possible side unwanted side effects. We believe this study will provide potential treatments for FSHD targeting the DUX4 gene.

PI_NAMEs: HARPER, SCOTT Q (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 4q35;adeno-associated viral vector;Adenosine;adenosine deaminase;Affect;Animal Disease Models;Arginine;autosome;base editing;Cell Line;Cells;Chimeric Proteins;Chromosomes;Chronic;Classification;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR/Cas technology;Cytidine;Data;Deamination;derepression;design;Disease;DNA;effective therapy;Effectiveness;Emerging Technologies;Engineering;Enzymes;Event;Facioscapulohumeral Muscular Dystrophy;Gene Expression;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;genome editing;Glutamine;Goals;Guanosine;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;Initiator Codon;Inosine;Length;Location;Mammals;Mediating;Messenger RNA;Methods;Methylation;model development;Modeling;Modification;Molecular;Mus;Muscle;Muscle Cells;Muscular Dystrophies;muscular dystrophy mouse model;Mutate;Myopathy;Neuromuscular Diseases;novel strategies;Other Genetics;Pathogenesis;Pathogenicity;Persons;Phenotype;postmitotic;pre-clinical;prospective;Proteins;Publishing;recruit;Ribosomes;Risk;RNA;RNA Editing;RNA Interference;RNA-targeting therapy;Safety;Side;side effect;Skeletal Muscle;Specificity;System;targeted treatment;Technology;Terminator Codon;Testing;Therapeutic;therapeutic genome editing;therapy design;therapy design/development;Transcript;transcription factor;transcriptome sequencing;Translations;Uridine;Viral Vector;Work

PROJECT_TITLE: CRISPR-Cas13 gene therapy and RNA editing for Facioscapulohumeral muscular dystrophy (FSHD)

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Congenital Heart Disease (CHD) is a global health burden that is a significant cause of infant mortality. The proposed research seeks to understand how these birth defects develop by looking at non-coding genetic variants in an abundant, poorly understood class of molecules called long non-coding RNAs (lncRNAs). This study will evaluate genetic variation in the human genome that impacts lncRNAs and advance our understanding of their role in disease development.

PI_NAMEs: PENALOZA, JACQUELINE STEPHANY (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Address;aggregation database;algorithmic methodologies;Architecture;Automobile Driving;base;Biological;Biological Process;Candidate Disease Gene;Cardiac;cardiogenesis;Cardiovascular system;causal variant;cell type;Cells;Child;Clinical;Code;cohort;Computational Technique;Computing Methodologies;Congenital Abnormality;congenital anomaly;congenital heart abnormality;Copy Number Polymorphism;Data;Data Analyses;Data Set;Development;developmental disease;Disease;disease phenotype;disease-causing mutation;Etiology;Frequencies;Future;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Research;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;Genomics;global health;Goals;Heart;heart defect;Heart Diseases;heart function;Human;Human Genetics;Human Genome;improved outcome;Infant Mortality;Information Theory;innovation;Investigation;Knowledge;laboratory experiment;Length;Machine Learning;machine learning model;malformation;Methods;Micro Array Data;Mission;Molecular;mouse model;Mus;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;new therapeutic target;novel;Open Reading Frames;Orthologous Gene;Pathogenesis;Pathogenicity;Pathway Analysis;Patients;Pattern;Play;Population;Probability;Process;Proteins;Publishing;Regulation;Research;RNA-Protein Interaction;Role;Single Nucleotide Polymorphism;single-cell RNA sequencing;stem;Structure;time use;Tissues;tool;Training;Transcript;transcriptomics;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Computational methods to elucidate the role of long non-coding RNA in Congenital Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_NAME: UNIVERSITY OF ROCHESTER

PROJECT_TERMS: 3-Dimensional;Accounting;Acetylcholine;Affect;Anatomy;Arteries;arteriole;Astrocytes;Biological Assay;Biosensor;Blood Vessels;Blood Volume;Brain;brain parenchyma;Cerebrospinal Fluid;Complex;Cyclic AMP;Dependence;design;Diffusion;Electroencephalography;Elements;Equation;experience;experimental study;Extracellular Space;fluid flow;glymphatic clearance;glymphatic function;glymphatic system;Goals;hemodynamics;Human;human data;human model;Image;in vivo;in vivo imaging;Link;Liquid substance;Measurable;Measurement;Measures;Metabolic;Metabolic Clearance Rate;Methods;model building;Modeling;Motion;Movement;Mus;network models;neural;neural circuit;Neuropil;neuroregulation;neurovascular unit;Norepinephrine;particle;Pattern;pressure;programs;Pump;rapid test;Resistance;Route;sensor;Sensory;Shapes;Signal Transduction;simulation;Sleep;solute;spatiotemporal;Specific qualifier value;Speed;Testing;two-dimensional;Validation;Variant;vasomotion;wasting

PROJECT_TITLE: Project 1: Modeling brain-state-dependent fluid flow and clearance in mice and humans


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Microbiome;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Millions of children aged 3-17 year have diagnosed anxiety disorders and are at higher risk for poor performance in school, difficulties in social situations, and increased substance use. The proposed study aims to examine the influence of exposure to toxic stress across the first years of life on the gut microbiota, which has been found to alter neurodevelopment and subsequent behavioral inhibition, leading to anxiety symptoms in later childhood. Given limited public health resources, it is important to identify these specific targets for early intervention and thus the proposed research has strong potential for advancing the NIMH's mission of transforming the understanding and treatment of mental illnesses.

PI_NAMEs: KNICKMEYER, REBECCA ;PROPPER, CATHI BARBRA (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 1 year old;Address;Adult;Age;Age Months;aged;Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety-related behavior;bacterial community;Behavior;Behavioral;Behavioral inhibition;behavioral outcome;Bifidobacterium;Biochemical;Biological Markers;biopsychosocial;Birth;Brain;brain behavior;brain pathway;caregiving;Child;Child Rearing;Childhood;Chronic;clinically significant;cohort;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Dimensions;early childhood;early experience;Early Intervention;environmental stressor;experience;Exposure to;Family;Fright;Functional Magnetic Resonance Imaging;Funding;Goals;Growth;gut colonization;gut microbiome;gut microbiota;gut-brain axis;Hair;Health Resources;high risk;high risk population;Hippocampus;Home visitation;Hormonal;Household;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;infancy;International;Intervention;Interview;Lactobacillus;Life;Literature;Long-Term Effects;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;maternal separation;Measurement;Measures;Medial;Mediating;Mediator;Mental disorders;microbial;microbial colonization;microbial community;microbiome;microbiome analysis;microbiota;Mission;Modeling;National Institute of Child Health and Human Development;National Institute of Mental Health;neural circuit;neurodevelopment;neuroimaging;neuropsychiatry;Neurosecretory Systems;novel;Nursery Schools;Participant;Pattern;Performance;Predisposition;Prefrontal Cortex;prevent;Prevention;preventive intervention;Problem behavior;prospective;Psychopathology;Psychophysiology;psychosocial;Psychosocial Influences;Psychosocial Stress;Public Health;Qualifying;Reporting;Research;Research Domain Criteria;Research Personnel;Resolution;response;Rest;Risk;Risk Factors;Rodent;Role;School-Age Population;Schools;Severities;social relationships;social situation;Source;stool sample;Strategic Planning;Stress;Structure;substance use;Testing;Time;Veillonella;Visit;Work

PROJECT_TITLE: The Development of Gut Microbiota and Behavioral Inhibition in Childhood: The Role of Early Stress and Brain Development

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]