NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health

PHR: Project Narrative – METHODOLOGY CORE The Methodology Core for the Center for Perioperative Mental Health engages a transdisciplinary team to support the translational research needs for the implementation of patient-centered mental health intervention bundles in real-world care settings. The Methodology Core will support the development and implementation of the proposed behavioral and pharmacological intervention bundle; employ a robust informatics infrastructure for the delivery and management of these interventions; and provide the research support for empirical evaluation of the intervention bundle using mixed-methods.

PROJECT_TERMS: Acceleration;Address;Anxiety;Behavioral;behavioral health;Biometry;Biostatistics Core;Caregivers;Caring;Characteristics;Clinical;Consolidated Framework for Implementation Research;Consultations;Continuity of Patient Care;Data Collection;data integration;data privacy;Data Security;Decision Making;Development;Dissemination and Implementation;Ensure;ethnographic method;Evaluation;experience;Fostering;Funding;Future;health care settings;Hospital Administration;hospital information services;Hospitals;implementation design;implementation evaluation;implementation intervention;implementation process;implementation science;implementation strategy;implementation study;improved;Informatics;informatics infrastructure;Infrastructure;Institution;instrument;Intervention;Mental Depression;Mental Health;mental health center;Methodology;Methods;Modification;Monitor;older adult;Operations Research;Operative Surgical Procedures;Outcome;Outcomes Research;participant interview;patient engagement;patient oriented;Patient Outcomes Assessments;patient population;Patient Preferences;Patients;Perception;Perioperative;Perioperative Care;pharmacologic;power analysis;preference;privacy protection;Process;Process Measure;programs;Publications;Qualitative Methods;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Support;Resources;scale up;Services;shared decision making;Statistical Data Interpretation;success;Supervision;System;tool;Training;Translational Research

PROJECT_TITLE: Methods Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Dementia;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_CITY: HANOVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: This project proposes to contribute toward identifying risk factors and elucidating their subcellular and cellular underpinnings for developing Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Identifying and investigating factors that increase risk for AD/ADRD is important, not only because it may guide us toward uncovering new biological mechanisms underlying AD/ADRD but also because it could help identify those individuals with high risk for developing it. In this proposal, we leverage our expertise and experience in studying brain development, employing a combination of neuroanatomical, electrophysiological and behavioral approaches to test the novel hypothesis that prenatal alcohol exposure early in gestation is a risk factor that predisposes the progeny to developing cognitive impairments that could lead to AD/ADRD later in life. We expect the findings of this project to point to new vistas and spawn new directions of investigation that will increase our understanding of prenatal alcohol exposure as a prospective risk factor for developing AD/ADRD and enhance our ability to predict and manage the development of AD at its early stages.

PI_NAMEs: YEH, HERMES H (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 3xTg-AD mouse;Acute;Adult;adverse outcome;Affect;Age;Age Months;Alcohol consumption;Alcohols;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;behavior test;Behavioral;behavioral impairment;Biological;Brain;Brain Diseases;Cells;Clinical;Clinical Research;Cognition Disorders;cohort;Complex;Data;Dementia;Dependence;Development;Early Diagnosis;Electrophysiology (science);Embryo;Epidemiology;epidemiology study;Equilibrium;Etiology;experience;experimental study;Female;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetus;flexibility;gamma-Aminobutyric Acid;Glutamates;Goals;high risk;Hippocampus;Impaired cognition;Impairment;Individual;innovation;Interneurons;Intervention;Investigation;Label;late life;Learning;Life;life span;Light;Link;Literature;male;maternal alcohol use;Medial;Mediating;Memory;migration;Molecular;mouse model;Movement;Mus;Neuroanatomy;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;Outcome;Parvalbumins;Pilot Projects;Positioning Attribute;postnatal;preclinical study;Predisposing Factor;Prefrontal Cortex;Pregnancy;pregnant;prenatal;prospective;Regimen;Reporting;Research;response;Retrieval;Reversal Learning;Risk Factors;sex;Slice;Somatostatin;Synapses;Synaptic Transmission;Testing;timeline;Video Microscopy

PROJECT_TITLE: Is prenatal alcohol exposure a risk factor for the onset and progression of AD/ADRD?


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE / RELEVANCE In this large, collaborative effort, we will examine how germline genetics, lifestyle factors, and tumor characteristics relate to the profile of T cells in colorectal cancers, and how those T cell profiles relate to cancer survival. The results of this work may ultimately inform strategies to harness the immune system for the prevention and treatment of colorectal cancer.

PI_NAMEs: OGINO, SHUJI ;PETERS, ULRIKE  (contact);PHIPPS, AMANDA IRENE

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Accounting;adaptive immune response;Adaptive Immune System;Address;Alcohol consumption;Area;Aspirin;Bacterial Genes;Bacterial Toxins;Bacteroides fragilis toxin;biomarker panel;Cancer Family;Cancer Prognosis;cancer survival;CD3 Antigens;CD8B1 gene;cell mediated immune response;cell type;Cells;Characteristics;colon cancer family registry;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;combinatorial;Data;density;Development;digital imaging;Dimensions;DNA sequencing;epidemiologic data;Epidemiology;epidemiology study;Evolution;Family-Based Registry;follow-up;FOXP3 gene;Fusobacterium nucleatum;Genes;Genetic;genetic resource;genetic variant;Genetic Variation;genome-wide;Genotype;Germ Lines;HLA Antigens;homeobox protein PITX1;Human;Immune;immune function;Immune response;Immune system;Immunofluorescence Immunologic;Immunoglobulins;Immunohistochemistry;Immunotherapeutic agent;insight;Killer Cells;Life Style;lifestyle factors;Machine Learning;Macrophage;microbial;Mutate;neoantigens;neoplastic cell;novel;Obesity;Observational Study;Oncogenic;Pathogenicity;Patient-Focused Outcomes;Pattern;Phenotype;Physical activity;Prevention;prognostic;Prognostic Factor;prognostic significance;prospective;Proteins;Ras/Raf;Receptor Gene;Research;Resources;response;Role;Signal Pathway;Signaling Protein;Smoking;Somatic Mutation;Spatial Distribution;stem;survival outcome;T cell response;T memory cell;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;tumor;Tumor Antigens;tumor microenvironment;Tumor Tissue;Uncertainty;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: Interdisciplinary Epidemiologic Consortium to Investigate T-cell Response in Colorectal Cancer

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Hematology;Human Genome;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Sepsis

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Trauma and surgical sepsis frequently lead to death and/or persistent critical illness, however there are no targeted therapies to improve outcomes. With advances in technologies, we can now measure changes in gene and protein expression in thousands of cells at the single cell level and at the same time measure levels of thousands of biomolecules in the circulation. We will continue to apply these technologies to the study of trauma and sepsis to identify predictive biomarkers and identify novel therapeutic targets.

PI_NAMEs: BILLIAR, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Age;Atlases;biomarker identification;Blood;Blood specimen;cell type;Cells;Cessation of life;Chromatin;Circulation;Comparative Study;Critical Illness;Data;Data Set;derepression;Development;Epigenetic Process;Functional disorder;Funding;Gene Expression;Hemorrhagic Shock;Human;Immune;Immune System Diseases;Immunosuppression;improved outcome;insight;Lead;Lipids;Measures;Morbidity - disease rate;mouse model;multidimensional data;Multiomic Data;multiple omics;new therapeutic target;novel;online resource;Operative Surgical Procedures;Organ;Outcome;patient stratification;Patients;Pattern;Peripheral Blood Mononuclear Cell;Polycomb;predictive marker;Predisposition;protein expression;Proteins;Publishing;Research;Resources;response;secondary infection;Secondary to;Sepsis;severe injury;sex;single cell genomics;systemic inflammatory response;targeted treatment;Technology;therapeutic target;Time;Translating;Trauma;Trauma patient;Work

PROJECT_TITLE: Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Osteoarthritis;Pain Research;Patient Safety;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative – PROJECT 1 Every year, 500,000 older adults undergo elective total hip or knee arthroplasty, and symptoms of anxiety and depression are common pre- and post-operatively. We propose to develop, adapt, and preliminarily test an intervention bundle providing psychological and medication optimization to these older adults.

PI_NAMEs: LENZE, ERIC J (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;age group;anti-depressive agents;Anxiety;anxiety symptoms;anxiety treatment;anxious;Attention;Behavior Therapy;Behavioral;Benzodiazepines;clinical practice;Clinical Trials Design;clinically significant;Communication;Community Practice;compare effectiveness;Degenerative polyarthritis;Delirium;Depressed mood;depressive symptoms;dosage;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;Elective Surgical Procedures;Emotional;Enrollment;Event;Evidence based intervention;experience;falls;Family;Goals;Grant;group intervention;Healthcare Systems;hip replacement arthroplasty;hospital readmission;Hospitals;human old age (65+);Hybrids;implementation outcomes;implementation/effectiveness;improved;Individual;innovation;interactive feedback;Intervention;knee replacement arthroplasty;Life;Mental Depression;Mental Health;Mental Health Services;Motivation;Multicenter Trials;multidisciplinary;Neurocognitive;older adult;older patient;Operative Surgical Procedures;opioid use;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;Participant;Patient Preferences;Patient-Focused Outcomes;Patients;Perioperative;Pharmaceutical Preparations;pharmacologic;Phase;physically handicapped;Population;Postoperative Period;Predisposition;Preparation;Process;programs;protocol development;Protocols documentation;Provider;Psyche structure;psychologic;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;reduce symptoms;Rehabilitation therapy;Replacement Arthroplasty;Reporting;Research Personnel;Risk;Second Look Surgery;shared decision making;symptomatic improvement;Testing;therapy development;Time;time interval;treatment as usual;trial design

PROJECT_TITLE: Perioperative mental health intervention for older adults undergoing hip and knee arthroplasty for osteoarthritis


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Patient Safety;Prevention

PHR: Project Narrative – PROJECT 2 The proposed research is highly relevant to public health because the prevalence of undertreated depression/anxiety coupled with the increasing incidence of cancer in older adults are creating a critical need for the integration of mental health interventions into clinical cancer care. Thus, the proposed research is relevant to the mission of the NIMH to transform the treatment of mental illnesses through clinical research, paving the way for prevention, recovery & cure.

PI_NAMEs: WILDES, TANYA M (contact)

PROJECT_TERMS: Acute;Address;adverse outcome;Affect;anti-depressive agents;Anxiety;anxiety symptoms;anxious;Attention;Behavior Therapy;Behavioral;Benzodiazepines;cancer care;cancer diagnosis;cancer surgery;Cessation of life;Climacteric;Clinical;clinical practice;Clinical Research;Clinical Trials Design;clinically significant;Communication;Community Practice;compare effectiveness;Coupled;Delirium;Depressed mood;depressive symptoms;Diagnosis;dosage;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;Emotional;Enrollment;Evidence based intervention;experience;falls;Family;Fright;Goals;Grant;group intervention;hospital readmission;Hospitals;human old age (65+);Hybrids;implementation outcomes;implementation/effectiveness;improved;Incidence;Individual;innovation;interactive feedback;Intervention;Malignant Neoplasms;medical complication;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mission;Morbidity - disease rate;mortality;Motivation;Multicenter Trials;multidisciplinary;National Institute of Mental Health;Newly Diagnosed;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Participant;Patient Preferences;Patient-Focused Outcomes;Patients;Perioperative;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Polypharmacy;Population;Postoperative Period;Preparation;Prevalence;Prevention;Procedures;Process;programs;protocol development;Protocols documentation;Provider;Psyche structure;Public Health;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;reduce symptoms;Research;Research Personnel;Risk;shared decision making;Surgical Oncology;Testing;therapy development;Time;time interval;treatment as usual;trial design

PROJECT_TITLE: Perioperative mental health intervention for older adults undergoing cancer surgery


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Radiation therapy has many benefits that explain its widespread use, but its curative potential is limited by the induction of toxicity in the tissues surrounding the tumor. This project aims to improve the efficacy of radiation therapy by combining it with high-intensity focused ultrasound. The hypothesis underpinning this scheme is that ionizing radiation nucleates nanosized gas bubbles, which would enhance cell killing through ultrasound cavitation effects.

PI_NAMEs: PRATX, GUILLEM  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Acoustics;Alpha Particles;Basic Science;Biological;Biological Assay;Biophysical Process;Cancer Patient;Caring;cell killing;Cells;Clinical;clinical practice;Combined Modality Therapy;Cosmic Radiation;Darkness;design;Diagnostic;Dose;Dose Limiting;experimental study;Exposure to;Focused Ultrasound;Focused Ultrasound Therapy;Gases;Hour;Human;improved;In Vitro;in vivo;in vivo Model;Incidence;innovation;Investigation;ionization;Ionizing radiation;irradiation;Kinetics;Lead;Liquid substance;Malignant Neoplasms;Measurement;Measures;Mechanics;Medicine;Membrane;microscopic imaging;millimeter;Modality;Modeling;nanobubble;nanosized;neoplastic cell;Neutrons;Normal tissue morphology;novel;Optical Methods;Organ;Organelles;Organism;Outcome;particle;Patients;physical property;Predisposition;prevent;Property;Radiation;Radiation Dose Unit;Radiation therapy;radioresistant;Reactive Oxygen Species;Resistance;response;Risk;Sampling;Scanning;Scheme;Seminal;spheroids;Temperature;Therapeutic;Tissues;Toxic effect;Translations;Treatment Efficacy;treatment planning;treatment strategy;tumor;Tumor Volume;Ultrasonics;Ultrasonography;ultrasound;Water

PROJECT_TITLE: Investigation of nanobubble nucleation by radiation therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE This project will determine the operational and regulatory mechanisms of the human polyamine uptake transporter ATP13A2 whose genetic disruption causes a spectrum of diseases associated with neuronal cell loss including Kufor-Rakeb syndrome, early-onset Parkinson’s disease, hereditary spastic paraplegia, neuronal ceroid lipofuscinosis and amyotrophic lateral sclerosis. Insights produced from the work proposed will lay the groundwork for future efforts to develop novel therapeutics that target neurodegenerative diseases.

PI_NAMEs: LEE, KENNETH PK (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Abnormal Cell;Address;Amyotrophic Lateral Sclerosis;Autoimmune Diseases;Autophagocytosis;Binding;Binding Sites;Biochemical;Biophysics;C-terminal;cancer cell;Cardiovascular Diseases;Cations;Cell membrane;Cell Physiology;Cell Proliferation;Cells;Chemicals;Clinical;Complex;Cryoelectron Microscopy;Cysteine;Cytosol;cytotoxic;Disease;Drug Targeting;early onset;Family;Future;Genetic;Goals;Health;Hereditary Spastic Paraplegia;Homeostasis;Human;human imaging;improved;inorganic phosphate;insight;Ion Channel;Ion Pumps;Knowledge;Lipid Bilayers;Lipid Binding;Lipids;loss of function mutation;Lumen of the Lysosome;Lysosomes;Maps;Mediating;Membrane Transport Proteins;Metabolism;Methods;Molecular;Molecular Conformation;Mutagenesis;Mutation;nanodisk;Neurodegenerative Disorders;neuron loss;Neuronal Ceroid-Lipofuscinosis;Neurons;new therapeutic target;novel therapeutic intervention;operation;PARK9 gene;Parkinson Disease;particle;pathogen;Pathway interactions;phosphatidylinositol 3,5-diphosphate;Phosphorylation;Physiology;Play;Polyamines;polycation;prevent;Protein Dephosphorylation;proteoliposomes;Proton Pump;Pump;rational design;reconstitution;Regulation;Research Project Grants;Resolution;Role;Route;Signal Transduction;Spermidine;Spermine;Stress;Structure;Syndrome;System;Testing;theories;Therapeutic;therapeutic target;three dimensional structure;Translations;Transmembrane Transport;Transport Process;uptake;Vacuum;Visualization;Work

PROJECT_TITLE: Structure and function of polyamine transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Heart Disease;Mental Health;Mental Illness;Patient Safety;Prevention

PHR: Project Narrative – PROJECT 3 The prevalence of undertreated depression/anxiety in older adults, coupled with the increasing number of cardiac interventions performed in this population, are creating a crucial need for the integration of mental health interventions into the critical perioperative period. Thus, the proposed research targets an important public health issue, and is relevant to the mission of the NIMH to transform the treatment of mental illnesses through clinical research, paving the way for prevention, recovery, and cure.

PI_NAMEs: AVIDAN, MICHAEL SIMON (contact)

PROJECT_TERMS: Address;adverse outcome;anti-depressive agents;Anxiety;anxiety symptoms;anxious;Attention;Behavior Therapy;Behavioral;Benzodiazepines;Cardiac;Cardiac Surgery procedures;Cessation of life;clinical practice;Clinical Research;Clinical Trials Design;clinically significant;Communication;Community Practice;compare effectiveness;Coupled;Delirium;Depressed mood;depressive symptoms;dosage;effective therapy;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;Emotional;Enrollment;Event;Evidence based intervention;experience;falls;Family;Fright;Goals;Grant;group intervention;Heart Diseases;hospital readmission;Hospitals;human old age (65+);Hybrids;implementation outcomes;implementation/effectiveness;improved;Individual;innovation;Intensive Care;interactive feedback;Intervention;medical complication;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mission;Morbidity - disease rate;mortality;mortality risk;Motivation;Multicenter Trials;multidisciplinary;National Institute of Mental Health;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Participant;Patient Preferences;Patient-Focused Outcomes;Patients;Perioperative;Pharmaceutical Preparations;pharmacologic;Phase;Polypharmacy;Population;Postoperative Period;Preparation;Prevalence;Prevention;Procedures;Process;programs;protocol development;Protocols documentation;Provider;Psyche structure;Public Health;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;reduce symptoms;Research Personnel;Risk;Risk Factors;shared decision making;social;Symptoms;Targeted Research;Testing;therapy development;Time;time interval;treatment as usual;trial design;United States

PROJECT_TITLE: Perioperative mental health intervention for older adults undergoing cardiac surgery


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Comprising a significant proportion of the global health workforce, nurses are uniquely positioned to develop and lead research to understand population health problems, inform health interventions, optimize health systems, and promote health within communities and across populations. The Research in Nursing and Global Health (RiNGH) training program aims to prepare junior nurse scientists with the knowledge and skills to advance global health equity through team-based, interdisciplinary research. This training will provide enhanced education, scholarly mentorship, and career development to pre-doctoral and post-doctoral trainees in nursing science.

PI_NAMEs: KOHLER, PAMELA  (contact);PINTYE, JILLIAN

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Discipline of Nursing;global health;Research;Training Programs

PROJECT_TITLE: RiNGH (Research in Nursing & Global Health) Training Program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Neutrophil recruitment to sites of injury is critical for host defense, however neutrophil activity in tissue can also lead to exacerbated inflammation and tissue injury. Our work suggests that neutrophil recruitment in inflamed mucosa is regulated via synergistic interactions of vascular endothelial cells and tissue macrophages. Thus, proposed studies will investigate new mechanistic aspects of macrophage effector function and their interactions with endothelial cells to regulate neutrophil trafficking in inflamed mucosa.

PI_NAMEs: SUMAGIN, RONEN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Actins;Acute;Adhesions;Adhesives;Binding;Blood Vessels;cadherin 5;CD31 Antigens;Cell Adhesion Molecules;Cell Physiology;Cells;Cues;cytokine;Cytoskeletal Modeling;Cytoskeleton;Data;Effector Cell;Endothelial Cells;Endothelium;Event;extracellular vesicles;Goals;healing;Homeostasis;Host Defense;Hot Spot;Immune;Immune response;improved;Infiltration;Inflammation;Inflammatory Bowel Diseases;Injury;Intercellular Junctions;interest;interstitial;intravital microscopy;Knockout Mice;Ligands;Ligation;Macrophage;Mediating;MicroRNAs;migration;Modeling;Molecular;molecular imaging;Molecular Target;Mucositis;Mucous Membrane;Mus;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;Pathologic;Physiological;Process;receptor;recruit;Regulation;Reporter;Resolution;response;Signal Transduction;Site;tissue injury;Tissues;trafficking;two-photon;Vascular Endothelial Cell;vesicular release;Work

PROJECT_TITLE: Vascular endothelial cells and macrophages coordinate neutrophil trafficking in inflammation

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Based on data from our lab and other labs, it has recently been suggested that transformation from castrate resistant prostate cancer (CRPC toward neuroendocrine prostate cancer (NEPC), a lethal form of prostate cancer, is associated with epithelial plasticity and induced by either N-Myc induction or RB1 loss. Currently, the synergy between MYCN induction and RB1 loss to drive progression to NEPC through the induction of DNA methylation proteins and methylation program are clinical unmet needs. Our multidisciplinary project, which builds on extensive and validated preliminary data, will provide insight and clinical rationale for treatment decisions and for patient selection for appropriate therapies, a step towards personalized cancer care.

PI_NAMEs: BELTRAN, HIMISHA ;RICKMAN, DAVID S. (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Address;Adenocarcinoma;advanced prostate cancer;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;antagonist;Anti-androgen Therapy;ASCL1 gene;Automobile Driving;biomarker driven;Cancer Patient;cancer type;Castration;Cell Differentiation process;Cell Survival;Chromatin;Clinical;clinically relevant;CRISPR/Cas technology;Data;deprivation;Development;Disease;DNA Methylation;DNA Modification Methylases;DNA Sequence Alteration;DNMT3B gene;effective therapy;enzalutamide;Epigenetic Process;epigenome;epigenomics;Epithelium;Future;Gene Expression;Genetic Models;Genetically Engineered Mouse;Genome;Goals;Histologic;In Vitro;in vivo;insight;Intervention;Knock-out;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Mediator;Methylation;Modeling;Molecular;multidisciplinary;mutant;MYCN gene;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Prostate Cancer;Neurosecretory Systems;novel;Organ;Organoids;Patient Selection;Patients;personalized cancer care;pharmacologic;Phenotype;prevent;Process;Prognosis;programs;Prostate;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Protein Methylation;Publishing;RB1 gene;Reader;Receptor Inhibition;Receptor Signaling;Regulation;Resistance;resistance mechanism;Role;Site;Small Cell Carcinoma;Specificity;synergism;targeted agent;targeted treatment;Therapeutic;Time;transcription factor;transcriptome;tumor;Visceral;Withdrawal;Xenograft procedure

PROJECT_TITLE: "DNMT and TET1 reprogramming as a targetable mechanism of resistance in advanced prostate cancer"

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The goal of the Building Access to Food through Systems and Solidarity (BASIS) Study is to improve diet by  providing culturally appropriate food access and attending to drivers that limit the ability to achieve nutrition  security in Sunset Park – a community of Mexican and Chinese American families in Brooklyn, NY that has been  hard-hit during the COVID-19 pandemic, has lagged in economic recovery, and where residents are  disconnected from government supports. We aim to implement and evaluate a whole-of-community intervention that will prioritize sustainability in the long-term, in partnership with four farming/gardening organizations, one  elementary school and three community-based organizations with programmatic offerings that will include  linkage to federal, state and local aid and workforce development; a subsidized fresh produce box program,  gardening and nutrition education; and a social marketing campaign to promote healthy eating. BASIS presents  a powerful model to improve diet in immigrant communities by addressing determinants of food access in a  community-centered, culturally competent way, and by fortifying community empowerment.

PI_NAMEs: YI, STELLA S (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Academia;Acceleration;Address;anti-Asian;Area;Asian Americans;Awareness;behavior change;built environment;Businesses;cardiometabolism;Cessation of life;Chinese American;Collaborations;Communities;community empowerment;community engaged research;community intervention;community organizations;community-centered;COVID-19 pandemic;cultural competence;Data Sources;Diabetes Mellitus;diabetes risk;Diet;Documentation;Economics;elementary school;Environment;Essential worker;ethnic minority population;Ethnic Origin;Evaluation;experience;Face;Family;Farm;Financial Support;Food;Food Access;Food Industry;Food Policy;Food Services;Fortification;Fright;Goals;Government;Health Disparities Research;health disparity;Healthy Eating;high risk;Immigrant;Immigrant community;implementation science;improved;Individual;Industry;Inequity;infrastructure development;Investments;Language;Latinx;Low income;Methods;Mexican Americans;Modeling;Needs Assessment;Neighborhoods;New York City;non-alcoholic fatty liver disease;nutrition;nutrition education;Outcome;Outcome Assessment;pandemic disease;Population;Program Development;programs;Public Health;racial minority population;Recovery;Research;Resources;Science;Security;Shame;social;social cohesion;Social Marketing;solidarity;Stimulus;Strategic Planning;Surveys;System;Trust;Unhealthy Diet;United States National Institutes of Health;vulnerable community;Workforce Development


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Despite their importance for every aspect of reproduction, the somatic tissues of the Drosophila female reproductive tract are relatively understudied. This work will use single-cell RNA- sequencing of mated and unmated females from two diverged natural populations to characterize reproductive tract cell diversity and gene expression evolution for the first time. Next, a set of reproductive tract genes will be knocked out and evaluated for reproductive function, including a) receptors in the seminal receptacle which may mediate the female post- mating response and b) newly-originated genes.

PI_NAMEs: THAYER, RACHEL C (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Alleles;Behavior;Biology;Birth;Candidate Disease Gene;cell type;Cells;Code;Communities;Complement;Complex;Conflict (Psychology);Data;Defect;Drosophila genus;Drosophila melanogaster;Ejaculation;Evolution;Exclusion;Exhibits;expectation;Exposure to;Female;female reproductive tract;Fertility;fly;gene discovery;Gene Expression;Genes;Genetic;Genetic Markers;Gland;Goals;insight;interest;Investigation;Investments;Knock-out;Label;Length;male;Measures;Mediating;model organism;Morphology;mutant;neural;novel;Organ;Outcome;paralogous gene;Partner in relationship;Play;Population;pressure;Process;Processed Genes;Proteins;Publishing;receptor;Receptor Gene;Reproduction;reproductive;Reproductive Biology;reproductive function;reproductive tract;Research;Resolution;Resources;response;Role;Seminal;Seminal fluid;sex;single cell sequencing;single-cell RNA sequencing;Site;sperm cell;Technology;Testing;Testis;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;United States National Institutes of Health;Uterus;women subjects;Work

PROJECT_TITLE: Gene expression and functional evolution in the Drosophila female reproductive tract

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Breastfeeding, Lactation and Breast Milk;Clinical Research;Infectious Diseases;Microbiome;Nutrition;Pediatric;Precision Medicine

PHR: PROJECT NARRATIVE The proposed study addresses our gap in understanding how the early life human gut microbiome responds to diet and antibiotics, including impacts on functional maturation and horizontal gene transfer of antibiotic resistance. This research is relevant for public health because it will improve our understanding of the effects of antibiotics and diet on microbiome dynamics beyond the coarse level of microbial communities and establish predictive models for future personalized antibiotic treatment and dietary recommendations that minimize collateral damage and maximize development of the healthy infant microbiome. By complementing data from two unique human cohorts with hypothesis testing in a mouse model this project is relevant to the NIH's mission of leveraging basic research in mechanisms of health and disease to improve outcomes in treatment and maintenance of human health.

PI_NAMEs: DANTAS, GAUTAM  (contact)

PROJECT_TERMS: 9 year old;Acute;Address;Adult;amino acid metabolism;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;bacterial community;Basic Science;Bioinformatics;Birth;Carbohydrates;Child;Childhood;cohort;Communities;conflict resolution;Data;de novo mutation;Development;Diet;dietary;Disease;early life exposure;early onset;Educational process of instructing;Environmental Exposure;Evolution;Exposure to;Feces;Future;Genetic Transcription;Genomics;Germ-Free;gut bacteria;gut microbiome;gut microbiota;Health;Heterogeneity;Horizontal Gene Transfer;Human;Human Milk;humanized mouse;improved;improved outcome;Individual;individual variation;Infant;infant gut microbiome;innovation;Interdisciplinary Study;Life;machine learning model;Maintenance;Maps;Medicine;metabolomics;Metadata;Metagenomics;metatranscriptomics;Microbe;microbial;microbial community;microbiome;microbiome composition;microbiome research;microbiota;Mission;Mobile Genetic Elements;mouse model;multiple omics;Neonatal;Patients;pediatric gut microbiome;personalized predictions;personalized risk prediction;Plasmids;predictive modeling;preterm newborn;Process;Property;Public Health;pup;Recommendation;Recording of previous events;repository;Research;resistance gene;Resolution;response;Risk;risk prediction;Shapes;Specimen;Statistical Models;Stimulus;Structure;Taxonomy;Testing;Training;Twin Multiple Birth;United States National Institutes of Health;Variant;Vitamins;Weaning;Work

PROJECT_TITLE: Impact of early-life perturbations on pediatric microbiome maturation

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Individuals experiencing financial strain (i.e., an inability to meet basic financial needs) may be more likely to use substances as a coping mechanism for the stress associated with financial strain, but they may also be eligible for financial support from anti-poverty programs such as the federal Earned Income Tax Credit (EITC). The few studies that have examined the relationship between financial strain and substance use have largely focused on alcohol and on acute financial strain due to sudden job or income changes, and have not explored whether financial support from federal policies such as EITC affect this relationship. Using 2013-2019 data from the Population Assessment of Tobacco and Health study, this project will examine: 1) whether financial strain is associated with cannabis, CNS depressant, alcohol, or polysubstance use, 2) how the duration of financial stain (i.e., acute financial strain due to sudden job or income loss, chronic financial strain due to persistent deprivation, and intermittent financial strain due to repeated economic insecurity) affects substance use, and 3) if financial support offered by the federal EITC may lower the risk of financial strain and subsequent substance use.

PI_NAMEs: GUTKIND, SARAH  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Accounting;Acute;acute stress;Adult;Affect;Alcohol consumption;Alcohols;Award;behavioral health;biological adaptation to stress;Cannabis;Cannabis policy;career;Central Nervous System Depressants;Chronic;coping mechanism;Data;Data Collection;deprivation;Drug usage;Economic Recession;Economics;Eligibility Determination;eligible participant;epidemiology study;experience;Family;federal policy;Financial Hardship;Financial Support;Funding;Future;Goals;healing;health economics;high risk;Housing;Income;Income Tax;Individual;insight;Institution;Intervention;Interview;K-Series Research Career Programs;Longitudinal cohort;Longitudinal Studies;Low Income Population;marijuana use;Mediating;Mental Health;Mentorship;Modeling;Modification;National Institute of Drug Abuse;novel;Occupations;Outcome;participant interview;payment;Perception;Persons;Policies;Policy Research;polysubstance use;Population Assessment of Tobacco and Health;Poverty;Prevalence;Principal Investigator;programs;psychosocial;Recreation;Reporting;Research;Research Personnel;Research Priority;Risk;Risk Reduction;Role;sex;Sex Differences;sex variable;social factors;Source;spelling;Stains;Stimulant;Stress;stressor;Structural Models;substance use;Substance Use Disorder;Sum;Surveys;Taxes;Time;trend;United States;Weight

PROJECT_TITLE: The Role of Financial Strain in Adult Alcohol, Cannabis, CNS Depressant and Polysubstance Use, and Mitigating Effects of Earned Income Tax Credit Policies: a Longitudinal Study using PATH data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Pediatric;Prevention

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE  The goal of this project is to understand how quantity and quality of the language input directed to children by their caregivers is influenced by genetically-influenced child characteristics of language and temperament. The overarching activity of this research project is transcription, coding, and analysis of naturalistic parent-child interactions that have been collected as part of a longitudinal study of over 300 same- sex twin pairs and their parents. The knowledge gained will reveal how child factors contribute to the parental language input children receive and the longitudinal consequences of this relationship.

PI_NAMEs: ARUNACHALAM, SUDHA  (contact);SAUDINO, KIMBERLY J.

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Affect;Age;Attention;Behavioral Genetics;Biometry;Caregivers;Characteristics;Child;Child Behavior;Child Language;Code;Data;Data Set;Data Sources;Dimensions;Dizygotic Twins;Educational Status;Environment;Environmental Risk Factor;Etiology;experience;Genes;Genetic;genetic analysis;genetic approach;Genetic Models;Genetic Transcription;Goals;Hearing;high risk population;improved;Individual Differences;Intervention;Investigation;Knowledge;Language;Language Development;Linguistics;Literature;Longitudinal Studies;Measures;Mediating;member;Modeling;Monozygotic twins;negative affect;novel;Parent-Child Relations;parental influence;parenting intervention;Parents;Play;Production;Property;Quantitative Genetics;Research;Research Activity;Research Project Grants;response;Role;Same-sex;Sampling;segregation;Source;standard measure;Temperament;Time;trait;transmission process;Twin Multiple Birth;Twin Studies;Variant;Vocabulary;Work

PROJECT_TITLE: Do children's genetically-influenced characteristics influence the parental input they experience? Evidence from a longitudinal twin study

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths in both men and women in the United States. This proposal aims to study an orally available inhibitor of the ATPases RUVBL1 and RUVBL2 as a radiosensitizer and immune stimulator for cancer therapy. If successful, this work may provide the framework for developing a combination therapy that enhances the efficacy of both radiotherapy and immune checkpoint inhibitors, which are currently used for treatment of patients with NSCLC.

PI_NAMEs: AKBAY, ESRA ;DAVIS, ANTHONY J;KITTLER, RALF  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: acute toxicity;Affect;anti-cancer;anti-PD-1;anti-PD1 antibodies;Antibodies;Antineoplastic Agents;antitumor effect;ataxia telangiectasia mutated protein;ATP phosphohydrolase;Biochemical;Biological Assay;Cancer cell line;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Cessation of life;checkpoint inhibition;chemotherapy;Chromatin;Clinical;Combined Modality Therapy;cytotoxic;Development;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA-dependent protein kinase;DNA-PKcs;drug development;efficacy evaluation;efficacy testing;External Beam Radiation Therapy;Genes;genetic variant;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunologic Stimulation;Immunotherapy;improved;In complete remission;In Vitro;in vivo;inhibitor;Ionizing radiation;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;men;Microscopy;Minority;Modality;Modeling;molecular targeted therapies;mouse model;mRNA Expression;Natural Immunity;new therapeutic target;Non-Small-Cell Lung Carcinoma;Nonhomologous DNA End Joining;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;PI-3-kinase-related kinase;Platinum;precision medicine;Proteins;Pulmonary Fibrosis;Radiation;Radiation therapy;Radiation Toxicity;Radiation-Sensitizing Agents;Radiosensitization;Recurrence;Research;Research Personnel;Resistance;Resources;response;Role;Signal Transduction;Site;Specificity;Structure of parenchyma of lung;synergism;Systemic Therapy;taxane;Testing;Therapeutic;Therapeutic Studies;timeline;Toxic effect;Treatment Efficacy;Treatment-related toxicity;tumor;Tumor Burden;United States;Woman;Work

PROJECT_TITLE: Development of a RUVBL1/2 Inhibitor as a Radiosensitizer and Immune Stimulator for NSCLC


NIH_SPENDING_CATS: Nutrition

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE  This study proposes to develop robust methods for analysis in one step of coenzymes and antioxidants that are fundamental to the functioning of all living cells and their abnormal levels are associated with numerous diseases including cancer, heart failure, diabetes, and obesity. Owing to the extremely unstable nature of these molecules, conventional analysis methods are suboptimal and lead to inaccurate and misleading outcomes in the assessment of cellular functions. Our ability to reliably measure the unstable metabolites in one step based on the outcome of the current investigations impacts numerous areas of biomedical science.

PI_NAMEs: GOWDA, G. A. NAGANA  (contact);RAFTERY, DANIEL

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acetyl Coenzyme A;Address;Aging;Antioxidants;Area;Biochemical Reaction;Biological;Blood;Cell Culture Techniques;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Clinical Trials;Coenzyme A;Coenzymes;cofactor;Cytoplasm;Development;Diabetes Mellitus;Disease;Ensure;enzyme activity;Equilibrium;experimental study;Freezing;Functional disorder;Glutathione Disulfide;Harvest;Health;Heart;Heart failure;In Situ;In Vitro;inhibitor;interest;Intervention;Investigation;Ion Channel;Isotope Labeling;Kinetics;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mediating;Metabolism;metabolomics;Methodological Studies;Methodology;Methods;Mitochondria;mitochondrial metabolism;Mus;NADH;NADP;Nature;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;nutrition;nutritional supplementation;Obesity;Organic solvent product;Outcome;Outcome Study;Outcomes Research;oxidation;Oxidation-Reduction;Precipitation;Proteins;Protocols documentation;pyruvate carrier;Reaction;Regulation;Research;Research Personnel;Sampling;Science;Signal Transduction;Skeletal Myoblasts;Starvation;Time;time use;Tissues;tool;Translating;Translations;Variant;Whole Blood

PROJECT_TITLE: Quantitative Analysis of Labile Metabolites in Biological Samples

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is a major public health problem, and is responsible for 1.7 million emergency department visits, hospitalizations, and deaths annually in the United States. This research will produce key mechanistic and outcomes data to understand the impact of autonomic dysfunction following severe TBI, and guide future trials aiming to modulate autonomic function following severe TBI. In doing this, the burden of poor neurologic outcomes following severe TBI could be reduced.

PI_NAMEs: KRISHNAMOORTHY, VIJAY  (contact);MILLER, JOSEPH BENJAMIN;VAVILALA, MONICA S

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Admission activity;Adult;Affect;Age;Ancillary Study;Autonomic Dysfunction;Autonomic nervous system;Biological Markers;Brain;Brain Injuries;brain tissue;Cardiac;Cephalic;cerebral hypoperfusion;Cerebrum;Cessation of life;Clinical;clinical care;Clinical Data;clinical efficacy;Clinical Trials;cohort;Cohort Studies;Complex;Critical Care;Data;Development;Emergency department visit;Frequencies;Functional disorder;functional outcomes;Future;Glasgow Outcome Scale;Goals;Guidelines;Heart Injuries;heart rate variability;hemodynamics;high risk;Hospitalization;Hour;Hypoxia;improved;improved outcome;Incidence;indexing;Individual;Inflammatory;Infrastructure;Injury;Injury to Kidney;injury-related death;Intracranial Hypertension;Intracranial Pressure;lung injury;Managed Care;Metabolic;mortality risk;Multi-Institutional Clinical Trial;Neurological outcome;Organ;Organ failure;organ injury;Outcome;Oxygen;participant enrollment;Patient-Focused Outcomes;Patients;Performance;phase III trial;Pilot Projects;post gamma-globulins;predictive modeling;Pressoreceptors;pressure;Prevalence;prevent;Public Health;receptor for advanced glycation endproducts;Research;risk prediction;Secondary to;Sedation procedure;sex;Signal Transduction;Standardization;Sympathetic Nervous System;TBI Patients;Telemetry;Testing;therapy development;Traumatic Brain Injury;treatment strategy;Troponin;United States

PROJECT_TITLE: Impact of Autonomic Dysfunction on Multi-Organ Dysfunction following Severe TBI: The AUTO-BOOST Study


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: General anesthetics (GAs) are used for hundreds of millions of surgeries each year, but growing evidence suggests that they may induce neurobehavioral deficits not only in the exposed subjects, but also in their offspring. These proposed studies in rodents are designed to test our new hypotheses on the underlying mechanisms, behavioral, neuroendocrine and transcriptomic blood-based biomarkers, and potential targets for pharmacological therapies of the heritable effects of GAs. This study will draw attention to the urgent need to investigate the heritable effects of GAs in humans and will build a foundation for such studies.

PI_NAMEs: MARTYNYUK, ANATOLY E (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acoustics;Acute;Affect;Alcohols;Androgen Receptor;Anesthesia procedures;antagonist;ARHGEF5 gene;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Biological Markers;Birth;bisulfite sequencing;blood-based biomarker;Brain;Bumetanide;Clinical;Clinical Research;Corticosterone;Data;Defect;design;Developed Countries;developmental disease;differential expression;Disease;DNA Methylation;Endocrine Disruptors;Enhancers;environmental stressor;Epigenetic Process;epigenome;epigenomics;ESR1 gene;Estradiol;Etomidate;experimental study;Exposure to;Flutamide;follow-up;forced swim test;Foundations;Fright;Future;Gene Expression;General anesthetic drugs;Generations;Genes;genome-wide;genome-wide analysis;Germ Cells;Germ Lines;Glucocorticoid Receptor;Heritability;Hippocampus;Hormones;Human;hypothalamic-pituitary-adrenal axis;Impairment;inhibitor;insight;intergenerational;Ketamine;Link;male;Masculine;Measures;Mediating;Methylation;Mifepristone;Modification;monocyte;morris water maze;neurobehavioral;Neurodevelopmental Disorder;Neurosecretory Systems;offspring;Operative Surgical Procedures;Parents;Partner in relationship;Patients;perinatal brain;peripheral blood;pharmacologic;Pilot Projects;postnatal;potential biomarker;pre-clinical;prepulse inhibition;Prevention strategy;Preventive therapy;Procedures;Process;programs;Propofol;Public Health;Rattus;Receptor Inhibition;Research;resilience;Rest;Rodent;Role;sevoflurane;Signal Transduction;sperm cell;Sprague-Dawley Rats;Steroids;Stress;stressor;Testing;Testis;Testosterone;Therapeutic;Therapeutic Effect;tool;transcriptome sequencing;transcriptomics;transmission process;Work;young adult

PROJECT_TITLE: Mechanisms and blood-based biomarkers of intergenerational neurobehavioral effects of general anesthetics


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Good quality sleep is essential for mental health as sleep has many beneficial and restorative effects like improving attention, working memory, emotional health, and clearing metabolic waste products. Conversely, insufficient sleep caused by stressful events markedly disrupts cognitive and emotional function, but little is known about how stress alters neural sleep circuitry. This proposal will reveal how sleep- and wake-active nuclei interact with stress-regulatory brain regions in order to elucidate neural circuit mechanisms underlying sleep homeostasis after chronic stress.

PI_NAMEs: WIEST, ALYSSA N (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Animals;Arousal;Attention;Axon;Behavior;Brain region;Calcium;Cell Nucleus;Chronic;Chronic stress;circadian;cognitive function;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRH gene;CRISPR/Cas technology;Emotional;emotional functioning;gene-editing approach;Genetic;Health;Homeostasis;Hypothalamic structure;Image;Impairment;improved;In Situ Hybridization;in vivo;in vivo calcium imaging;in vivo monitoring;Injections;insight;Label;Mediating;Mental disorders;Mental Health;Metabolic;Monitor;mouse model;neural;neural circuit;neuromechanism;Neurons;new therapeutic target;non rapid eye movement;optogenetics;paraventricular nucleus;Patients;physical conditioning;Pituitary Gland;Play;Population;Preoptic Areas;pressure;receptor;REM Sleep;response;Risk;Role;Short-Term Memory;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep regulation;Sleep Wake Cycle;social defeat;Stress;Stressful Event;vigilance;Wakefulness;Waste Products

PROJECT_TITLE: Neuronal and homeostatic regulation of sleep and wake by corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Lung

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The number of fungal infections has risen dramatically in the United States over the last 15 years, and is now among the top 10 causes of death, partly because we lack novel and effective therapeutic drugs against fungi. To address this unmet medical need, we are working on understanding how the host senses and effectively restrains fungal growth. The knowledge gained will lead to the development of new and better strategies to therapeutically treat microbial pathogens.

PI_NAMEs: WUETHRICH, MARCEL  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Abbreviations;Address;Alveolar;Antibodies;antimicrobial;Blastomyces dermatitidis;Bone Marrow;Cause of Death;CD4 Positive T Lymphocytes;Cells;Colony-forming units;combat;Data;Defect;Dendritic Cells;design;Development;Effector Cell;Endowment;Epithelial Cells;Exclusion;Family;fungus;Future;Growth;Hematopoietic;Hour;Immune;In Vitro;in vivo;Infection;Innate Immune Response;innovation;insight;Knowledge;Leukocytes;Lung;Lung infections;Lymphocyte;Lymphoid Cell;Mediating;Medical;Microbe;microbial;Modeling;Molecular;monocyte;mouse model;Mucous Membrane;Mus;Mycoses;Myeloid Cells;Natural Immunity;Natural Killer Cells;neutrophil;Neutrophil Activation;Nitric Oxide;novel;novel therapeutic intervention;pathogen;pathogenic fungus;pathogenic microbe;Pathway interactions;Phagocytes;Pharmaceutical Preparations;Population;Production;Publishing;Reactive Oxygen Species;receptor;Receptor Signaling;Reporting;Resistance;respiratory;restraint;Role;sensor;Signal Transduction;Stains;Stromal Cells;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;United States;vaccine development;Vaccines;Wild Type Mouse;Work;Yeasts

PROJECT_TITLE: Cellular and molecular mechanisms involving SLAMF1 during pulmonary fungal infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Telehealth;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The perinatal period, defined as the time period during pregnancy and up to one year postpartum, is a vulnerable period for women affected by opioid use disorder, and which may be compounded by loneliness and social isolation leading to an increased risk of relapse, overdose, and even death. Despite recent advances in telehealth programs for postpartum women and for individuals with substance use disorders, no current treatment models exist to integrate maternal perinatal and OUD treatment with an emphasis on loneliness and social isolation. In order to adapt an existing supportive texting chatbot to decrease feelings of loneliness and increase engagement in OUD and perinatal care, we now embark on a study utilizing steps from intervention mapping to identify needs of perinatal women with OUD, develop new content appropriate to our target population, refine the accuracy of the content and messaging, and test the feasibility and acceptability of our new model, the Penny COPILOT.

PI_NAMEs: KORNFIELD, SARA L. (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;Address;adverse birth outcomes;Adverse event;Affect;Birth;care providers;Caring;Case Manager;Cementation;Cessation of life;chatbot;Childbirth;Chronic;Client satisfaction;Clinical;Collaborations;Consolidated Framework for Implementation Research;COVID-19 pandemic;Data;design;Development;Discipline of obstetrics;Effectiveness;Employment;Ensure;experience;feasibility testing;Feedback;Feeling;fetal;Friends;Goals;Health Services Accessibility;Health Technology;Hospitals;implementation research;improved;Individual;Infant;Intervention;intervention mapping;Lactation;Lactation consultant;Learning;Link;Loneliness;Low Birth Weight Infant;Maintenance;maternal morbidity;Maternal Mortality;maternal opioid use;medical complication;member;Mental Depression;Mental Health;Methods;Modeling;Monitor;Mood Disorders;mortality;Mothers;multidisciplinary;National Institute of Drug Abuse;Natural Language Processing;Needs Assessment;Neonatology;opioid epidemic;opioid use;opioid use disorder;Outcome Study;Overdose;Participant;patient engagement;Patients;peer;Perinatal;Perinatal Care;perinatal mental health;perinatal period;perinatal women;Phase;pilot test;Population;Postpartum Depression;Postpartum Period;Postpartum Programs;Postpartum Women;preference;Pregnancy;pregnant;Premature Birth;Prevalence;prevent;programs;Provider;Psyche structure;Recommendation;Recovery Support;Relapse;relapse risk;Research Methodology;response;Risk;Safety;Sampling;satisfaction;screening;Screening Result;Services;social;Social Distance;Social isolation;Specialist;substance abuse treatment;Substance Use Disorder;Symptoms;Target Populations;telehealth;Testing;Text Messaging;texting support;Time;treatment adherence;Triage;Woman;Work

PROJECT_TITLE: Adapting the Penny Chatbot for Perinatal OUD Patients:  COPILOT


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Antibiotics are widely used to treat human infections. However, in addition to targeting the intended pathogen, the top prescribed antibiotics also disrupt the healthy human microbiome, increasing susceptibility to various diseases. We propose to explore natural product peptides that selectively antagonize the activity of broad- spectrum antibiotics as a strategy to minimize this collateral damage.

PI_NAMEs: EUSTAQUIO, ALESSANDRA S (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anabolism;Animals;Antibiotic Therapy;Antibiotics;Antidotes;Aromatic Compounds;Bacillus;Bacteria;Bacterial natural products;clinically relevant;commensal bacteria;Crude Extracts;Data;Depsipeptides;Disease;Disease Outcome;Doxycycline;Drug Kinetics;dysbiosis;Erythromycin;Family;Future;Growth;gut microbiota;Health;Health Personnel;Human;Human Microbiome;human pathogen;Improve Access;Infection;Inflammatory Bowel Diseases;insight;Knock-out;large scale production;Learning;Length;Libraries;Malignant Neoplasms;marine;Mental disorders;Methods;Microbe;microbiome;mutant;Names;Natural Products;Nature;Neurodegenerative Disorders;Oral;Outcome;Outpatients;pathogen;pathogenic bacteria;peptide natural products;Pharmaceutical Preparations;Pharmacologic Substance;Porifera;Predisposition;prevent;Reporting;Role;screening;Series;Side;Testing;Therapeutic;Toxic effect;Translating;United States;water solubility

PROJECT_TITLE: Marine sponge depsipeptides to minimize antibiotic collateral damage

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prevention;Substance Misuse

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Patients have knowledge, attitudes, beliefs, and perceptions of pain and addiction that inform decisions for the use of opioids for acute pain management. Improved understanding is essential to formulate effective strategies to reduce opioid exposure while maximizing pain relief. The goal of this research is to understand and intervene upon decisions in the emergency department that may lead to unnecessary pain and increased addiction.

PI_NAMEs: PUNCHES, BRITTANY E (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Acute Pain;Acute pain management;addiction;Address;Affect;Attention;Attitude;Behavior Therapy;Belief;care seeking;career development;Caring;Characteristics;Clinical;Clinical Research;Cognitive;Computer Assisted;Data;Decision Making;demographics;design;Development;disorder risk;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency department visit;Enrollment;Equilibrium;evidence base;experience;Factor Analysis;Familiarity;Focus Groups;follow-up;Funding;Future;Goals;Guidelines;Health;Health Services;Health Services Accessibility;Healthcare;Iatrogenesis;improved;Incidence;Individual;Infection;Infrastructure;injection drug use;innovation;Intervention;Interview;Investigation;K-Series Research Career Programs;Knowledge;Measures;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;multidisciplinary;Naloxone;Opioid;opioid epidemic;opioid exposure;opioid therapy;opioid use;opioid use disorder;Overdose;Pain;Pain management;pain perception;pain relief;Participant;patient engagement;Patients;Perception;Pharmacy facility;Population;predictive modeling;prescription opioid;Prevalence;Prevention strategy;Primary Prevention;programs;prospective;Provider;Psychometrics;Qualifying;Random Allocation;Recording of previous events;reduced substance use;Research;Research Personnel;Risk;Role;safety net;Sampling;Secondary Prevention;shared decision making;Site;Statutes and Laws;Substance Use Disorder;Surveys;Testing;Therapeutic;therapeutic opioid;Therapeutic Uses;tool;Training;Validation

PROJECT_TITLE: Decision-Making Factors for Therapeutic Opioid Use after Emergency Care

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_DEPT: CHEMISTRY

PHR: Methods for evaluating the fate of single virions have led to a wealth of information on disease states but have been primarily limited to surface studies and artificial culture environments. This work will develop and apply high-speed 3D single-virus tracking methods to capture how viruses such as influenza and SARS-CoV-2 navigate the complex epithelial space. Outcomes from this work will shed light on the mechanisms through which virions traverse the first line of defense of the human immune system.

PI_NAMEs: WELSHER, KEVIN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Affect;Bacterial Infections;Behavior;Cells;cellular imaging;Complex;Cultured Cells;design;Development;Diffusion;Disease;env Gene Products;Environment;Epithelium;Equilibrium;Exclusion;experimental study;Feedback;Funding;Gastrointestinal tract structure;Glycocalyx;Guidelines;Hemagglutinin;Human;Image;Immune system;in vivo;Influenza;Influenza A virus;insight;Lung;meter;Methods;Microscopy;Modeling;Molecular;Mucous body substance;nanoparticle;Neuraminidase;Organism;Outcome;particle;Pathway interactions;Phase;Photons;Positioning Attribute;Process;receptor;receptor binding;Sampling;Sialic Acids;Silver;Speed;Surface;Techniques;temporal measurement;Testing;Therapeutic;Time;Tissues;trafficking;Vesicular stomatitis Indiana virus;Viral;Virion;Virus;Virus Diseases;virus infection mechanism;Virus-like particle;Viscosity;walker;Work

PROJECT_TITLE: Unraveling the Viral Infection Pathway with Virus-locked Observation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Heart, lung and blood related diseases are leading causes of death in the US and around the world. Understanding the sex-specific genetic architecture for the risk factors for these traits in diverse populations (e.g. tobacco and alcohol use, lipids levels, obesity, etc) can aid in the discovery of the underlying biology, inform preventive strategies, and improve risk prediction, which are of great public health relevance.

PI_NAMEs: JIANG, BIBO ;LIU, DAJIANG  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Acceleration;addiction;Address;Alcohol consumption;ancestry analysis;Biology;Blood;Blood Pressure;causal variant;Cause of Death;Collaborations;Complex;Data;Data Aggregation;Data Analyses;Data Set;Disease;empowerment;Environmental Exposure;European;European ancestry;Female;Frequencies;Genetic;genetic architecture;genetic association;Genetic Heterogeneity;Genetic Models;Genetic Research;Genetic study;genetic variant;genome wide association study;genomic locus;genotypic sex;Heart;Heterogeneity;Human Genetics;improved;Individual;innovation;Joints;Licensing;Linkage Disequilibrium;Lipids;Lung;male;Maps;Meta-Analysis;method development;Methodology;Methods;Modeling;multi-ethnic;National Human Genome Research Institute;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Pattern;Phenotype;polygenic risk score;Population;Population Heterogeneity;Prevention strategy;Privacy;public health relevance;rare variant;Research;Research Personnel;Resolution;Resource Sharing;Risk Factors;risk prediction;Sample Size;Sampling;Series;sex;Sex Ratio;Software Tools;statistics;Strategic Planning;Tobacco use;tool;training data;trait;United States National Institutes of Health;Variant

PROJECT_TITLE: Methods to unveil sex-specific genetic architecture in trans-ancestry meta-analysis

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE The proposed work will demonstrate a new bioprinting technique enabling high-throughput positioning of tissue spheroids in a precise manner in three dimensions (3D) and explore the use of such a technique for fabrication of bone tissue and bronchopulmonary segments. Successful completion of the proposed work will have a great potential to pioneer the development of disruptive high-throughput bioprinting technologies and advance their utilization in fabrication of organ substitutes.

PI_NAMEs: OZBOLAT, IBRAHIM  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;Air;Alginates;Anatomy;Bathing;Benchmarking;Biocompatible Materials;bioprinting;bone;Bone Tissue;Cell Density;cell injury;Cell Survival;Cells;Collaborations;Complex;craniofacial;Craniofacial Abnormalities;craniofacial repair;craniomaxillofacial;Data;Defect;density;Deposition;design;Development;Device or Instrument Development;disease model;Drug Screening;drug testing;Effectiveness;Encapsulated;Exhibits;experience;Extracellular Matrix;fabrication;Gel;Goals;high throughput technology;Human;Hydrogels;Individual;Industry;Ink;instrument;Knowledge;manufacturing technology;Measurable;Medical;Modeling;new technology;novel;Nude Rats;Operative Surgical Procedures;Organ;Organoids;osteogenic;Pattern;Physiological;Polymers;Positioning Attribute;Process;process repeatability;Property;Rattus;Regenerative Medicine;repaired;scaffold;Science;self assembly;Shapes;Site;Speed;spheroids;Structure;Structure of parenchyma of lung;Surface;Techniques;Technology;technology development;Testing;Tissue Engineering;Tissue Transplantation;Tissues;tool;Translations;Work

PROJECT_TITLE: High-throughput Spheroid Bioprinting Technology for Scalable Fabrication of Tissues

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Aging

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The Aging and Development Training program at Washington University provides state- of-the art predoctoral and postdoctoral training in the psychological science of human aging. The program is distinctive in its focus on psychological and behavioral science, while providing intentional interdisciplinary instruction in the biology and sociocultural aspects of human aging. Grounded in the highly-ranked Department of Psychological & Brain Sciences, the program draws on faculty from across Washington University.

PI_NAMEs: HEAD, DENISE ;ZACKS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Aging;Development

PROJECT_TITLE: Aging and Development


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_NAME: STEELWORKER CHARITABLE/EDUCATIONAL ORG

PHR: Project Narrative: Using our cadre of 190 USW, CWA, immigrant worker center and Tribal trainers we will provide HAZMAT, HAZWOPER and related OSHA training to those who produce, work with, dispose of and transport billions of pounds of hazardous substances and wastes. Our target populations are 1) high hazard unionized workers, especially those who must respond to emergencies; 2) immigrant day laborers who are hired from street corners to engage in clean up and (re)construction activities; and 3) Tribal members who must respond to a growing number of toxic spills and weather-related disasters on their lands. Our mission is to bring high quality model education to thousands of workers who currently receive insufficient training on the hazards they face so that at-risk workers can better protect themselves, their co-workers and their communities.

PI_NAMEs: FITCH, ASHLEE  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Advocate;Age;Area;arm;Automobiles;Cementation;Cessation of life;Chemicals;Climate;climate change;climate science;combat;Communicable Diseases;Communication;Communities;community organizations;Country;Dental Pulp;Development;Disasters;Education;Education Projects;Educational Models;Emergency medical service;Emergency response;Emergency Situation;Environment;ergonomics;Evaluation;experience;Explosion;Exposure to;Face;Fire - disasters;Funding;Gender;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;health disparity;Health Personnel;health training;Healthcare;Hispanic;Hour;Immigrant;Immigrant worker;improved;Income;industrial production;Industrialization;Industry;Injury;Investigation;Joints;Latino;Learning;Link;Location;manufacture;Medical;meetings;member;Mental Health;Mentors;Mentorship;Metals;Mining;minority communities;Mission;model building;Multilingualism;New York;Nuclear Energy;Occupational;Occupations;Oils;Opioid;opioid epidemic;opioid use;Paper;Participant;patient home care;peer;Pharmacologic Substance;Plastics;Poison;Police;Policies;Population;prevent;Prevention;Prevention program;Program Development;programs;Regulation;Reservations;response;retiree;Risk;Risk Factors;Rubber;Running;Safety;Services;Site;Spanish;Stigmatization;Stress;Target Populations;Telecommunications;Time;Toxics Release Inventory;Training;Training Activity;Training and Infrastructure;Transportation;tribal community;Tribal Council;tribal lands;tribal member;Tribes;Umatilla;underserved minority;weather-related disaster;Woman;Work;working group;Workplace;Yakama Indian

PROJECT_TITLE: Training At-Risk Industrial, Telecommunication and Immigrant Workers to Assess and Improve their Health and Safety Conditions


NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Advocacy;Advocate;arm;Automobiles;Cementation;Cessation of life;Chemicals;Climate;climate change;climate science;Coeur D'Alene;Collaborations;college;Communication;Communities;Competence;Country;Dental Pulp;Doctor of Medicine;Doctor of Philosophy;Education;Educational Curriculum;Elements;Emergency medical service;Emergency Situation;Environment;Evaluation;Explosion;Exposure to;Fire - disasters;Foundations;Funding;Hazardous Chemicals;Hazardous Substances;Health;Health education;Healthcare;high risk;Hour;Immigrant;Immigrant worker;improved;Industrialization;Injury;International;Investigation;Lead;Leadership;Link;Longterm Follow-up;manufacture;Medical;member;Mentors;Mentorship;Metals;Mining;Modeling;Needs Assessment;New Jersey;New York;Nuclear Energy;Occupational injury;Occupations;Oils;Opioid;opioid use disorder;Paper;patient home care;peer;Pharmacologic Substance;pilot test;Plants;Plastics;Police;Policies;Population;prescription opioid;prevent;preventable death;Prevention;Prevention program;Program Development;programs;Readiness;Research;response;Risk;Rubber;Safety;safety education;Services;Site;Spanish;Spanish/English;Stress;System;Target Populations;Telecommunications;tool;Trainers Training;Training;Training Activity;training project;Transportation;tribal community;Tribal Council;tribal lands;tribal member;Tribes;Umatilla;Universities;wasting;Work;Workplace;Yakama Indian

PROJECT_TITLE: HWW


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Climate-Related Exposures and Conditions;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Administrator;Area;arm;Automobiles;Cementation;Certification;chemical responder;Chemicals;climate change;climate impact;college;Communication;Communities;community center;community organizations;Dental Pulp;Disasters;Doctor of Medicine;Doctor of Philosophy;Education;Educational Curriculum;Elements;Emergency medical service;Emergency response;Emergency Situation;Employee;Environment;Evaluation;Event;exhaustion;Exposure to;Face;Fire - disasters;Funding;Government;hazard;hazardous materials worker;Hazardous Substances;Health;Healthcare;high risk;Hour;Hurricane;Immigrant;Immigrant community;Immigrant worker;improved;Industrialization;Infrastructure;Instruction;Joints;Lead;Link;Location;Longterm Follow-up;Maintenance;manufacture;Medical;member;Metals;Mining;Modeling;Multilingualism;New York;Nuclear Energy;Occupational injury;Oils;operation;Opioid;opioid use disorder;Paper;patient home care;Pharmacologic Substance;pilot test;Plastics;Police;Population;prescription opioid;Prevention;Procedures;Process;programs;Readiness;Recommendation;Regulation;repaired;resilience;Resources;response;Rights;Risk;Rubber;Safety;Safety Management;Security;Services;Site;Spanish;Spanish/English;Spottings;Staging;Stress;System;Target Populations;Telecommunications;Time;tool;Training;Transportation;tribal community;tribal lands;tribal member;Tribes;Umatilla;Work;working group;Workplace;Yakama Indian

PROJECT_TITLE: Assessing and Preparing for Disasters


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative The proposed research is directly relevant to public health because it will uncover key neurodevelopmentally- regulated neural circuit mechanisms that enable the maturation of the prefrontal cortex during adolescence and the neurobiology that renders this developmental period susceptible for the onset of psychiatric disorders. This goal is directly aligned with the NIMH agenda by establishing a developmental framework in which mental disorders can be understood, specifically those arising during the adolescent transition to adulthood. This knowledge is expected to fully serve NIH mission by devising the proper timing of intervention strategies to prevent or mitigate the onset of mental disorders during critical periods.

PI_NAMEs: TSENG, KUEI-YUAN  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acoustics;Adolescence;Adolescent;Adult;Affective;Age;Anatomy;antagonist;Behavior;Behavioral;behavioral response;Brain;Calibration;cell type;Cognitive;cognitive ability;critical period;Data;Decision Making;Development;Developmental Process;Disease;Electrophysiology (science);Equilibrium;Event;Exhibits;fear memory;gamma-Aminobutyric Acid;genetic approach;Glutamates;Goals;Grant;hippocampal pyramidal neuron;Hippocampus;in vivo;Incidence;Infusion procedures;insight;Interneurons;Intervention;Knowledge;Link;Mediating;Mental disorders;Mission;N-Methylaspartate;National Institute of Mental Health;neural;neural circuit;Neurobiology;neurodevelopment;neuronal circuitry;novel therapeutic intervention;Output;postnatal;postnatal development;postnatal period;Predisposition;Prefrontal Cortex;prepulse inhibition;prevent;Process;Public Health;Regulation;Reporting;Research;response;Risk Factors;Schizophrenia;Substance Use Disorder;Synapses;Testing;transition to adulthood;transmission process;United States National Institutes of Health;vulnerable adolescent

PROJECT_TITLE: Afferent Regulation of Prefrontal Maturation during Adolescence

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Heart Disease;Microbiome;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Transthyretin cardiac amyloidosis, a particularly deadly form of heart failure, can now be treated by recently developed medications. The proposed projects will develop new heart imaging approaches to determine who is likely to respond to the new medicines, test a new ultrasound-based therapy to improve blood flow to the heart muscle and thereby improve delivery of novel drugs to the heart, and study bacteria in the stool with the goal of eventually developing diet-based strategies to address cardiac amyloidosis. In developing methods to improve treatments for amyloidosis, this project will support expansion of Dr. Dorbala’s patient oriented research program and enhance training for her mentees.

PI_NAMEs: DORBALA, SHARMILA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Adult;Affect;Ammonia;Amyloid Fibrils;Amyloidosis;automated segmentation;Award;Bacteria;Blood flow;Cardiac;cardiac amyloidosis;cardiac magnetic resonance imaging;Cardiac Volume;cardiovascular imaging;career;Cessation of life;Clinical;clinical investigation;Clinical Research;Clinical Trials;cohort;Complement;cost;Data;data registry;Databases;Death Rate;Deposition;Development;Diagnosis;Diet;Diphosphates;Drug Delivery Systems;Drug Targeting;effective therapy;EFRAC;Elderly;Excision;extracellular;Failure;fecal microbiota;Feces;follow-up;Foundations;frontier;Funding;Goals;Grant;gut microbiome;hazard;Heart;Heart failure;heart imaging;Hospitals;Image;Image Analysis;imaging approach;improved;improved outcome;Individual;Industrialization;innovation;International;interstitial;Intervention;Life;Light;Machine Learning;Measurement;Measures;Mediating;medical schools;Medicine;Mentors;metagenomic sequencing;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;molecular imaging;mortality;multi-scale imaging data;Myocardial;Myocardial perfusion;Myocardium;next generation;novel;novel marker;novel strategies;novel therapeutics;nutrition;Outcome;Paper;patient oriented research;Patients;Perfusion;personalized strategies;PET/CT scan;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Postdoctoral Fellow;pre-doctoral;Prealbumin;Prediction of Response to Therapy;preservation;prevent;Preventive;Probability;programs;Protein Precursors;Proteins;Public Health Schools;Publishing;Radiology Specialty;radiomics;Research;Research Activity;Research Personnel;Research Project Grants;Research Proposals;Resources;response;Rest;Risk;sarcopenia;Scientist;Shotguns;single photon emission computed tomography;sonoporation;Source;Spearman Rank Correlation Coefficient;stool sample;success;survival prediction;Symptoms;targeted treatment;Technical Expertise;Techniques;Testing;Texture;Therapeutic;Training;Treatment Failure;treatment response;treatment strategy;ultrasound;United States National Institutes of Health;Woman;Work;X-Ray Computed Tomography;β-amyloid burden

PROJECT_TITLE: Mentoring Patient Oriented Research in Innovative Imaging and High-dimensional Data Approaches to Improve Outcomes in Cardiac Amyloidosis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The major goal of this ongoing, successful training program is to provide microbiology trainees additional knowledge in infectious diseases and the skills to recognize opportunities for translation of new knowledge into clinical applications. An optimal environment is provided for (1) training in the latest concepts and techniques of microbiology research, (2) enhancing understanding of current challenges in infectious diseases, and (3) preparation for careers that influence research efforts that lead to more rapid resolution of important infectious disease problems. The program will continue to recruit highly qualified trainees from underrepresented groups, increasing the diversity of scientists performing research at the cutting edge of the microbiology/infectious disease interface.

PI_NAMEs: LORENZ, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Molecular Basis of Infectious Diseases Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: In this proposal, we aim to define how cells in the blood vessels in the lung communicate with each other and promotes the development of a deadly yet mysterious disease, pulmonary arterial hypertension (PAH). In doing so, we will test a new inhaled drug therapy for this disease, and we will embark on a first-in-human study to define a new imaging technique for better detection of PAH. If successful, our work could shape the principles of how PAH develops, offering much needed and more effective ways to detect and treat this deadly condition.

PI_NAMEs: CHAN, STEPHEN Y (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: 18F-Glutamine;amino acid metabolism;Amino Acids;Automobile Driving;Award;Blood Vessels;Catabolism;Cell Aging;Cell Communication;Cell Cycle Arrest;Cell Senescence Induction;cell type;Cells;Collagen;combinatorial;Communication;Critical Pathways;Deposition;Detection;Development;Diagnostic;Disease;drug inhalation;efficacy evaluation;Encapsulated;Endothelial Cells;Endothelium;Enzymes;Etiology;Event;Exercise;Feedback;Fibroblasts;first-in-human;Funding;Genetic;Glutaminase;Glutamine;Human;human RNA sequencing;human study;Image;Imaging Techniques;Inflammatory;Ingestion;Inhalation;Inhalation Therapy;Isotopes;Knock-out;Knockout Mice;Label;Link;Lung;Maintenance;mass spectrometric imaging;Measures;Mediating;Metabolic;Metabolism;Molecular;multidisciplinary;Mus;nanoparticle;new therapeutic target;novel;novel diagnostics;Pathogenicity;Patients;PET/CT scan;Pharmacotherapy;Positioning Attribute;Positron-Emission Tomography;Proteins;pulmonary arterial hypertension;Pulmonary vessels;Reporting;Right ventricular structure;Rodent;Role;senescence;senescence associated secretory phenotype;Serine;Shapes;Signal Transduction;single-cell RNA sequencing;small molecule;spectrograph;System;Systemic Scleroderma;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissues;Tracer;Transcription Coactivator;uptake;Vascular Proliferation;Work

PROJECT_TITLE: An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  This project aims at generalizing the LIBRA-seq technology for high-throughput mapping of antibody sequence to antigen specificity to make it universally applicable to a broad diversity of antigen targets, in the context of a wide range of antibody discovery problems. Ultimately, the LIBRA-seq technology will have a long- lasting impact on both basic and applied immunology, helping revolutionize our understanding of antibody- antigen interactions and leading to the discovery of novel antibody therapeutics targeting a large variety of disease areas of biomedical significance.

PI_NAMEs: GEORGIEV, IVELIN  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immune response;Address;Antibodies;antibody and antigen binding;Antibody Response;Antibody Specificity;antigen binding;Antigen Targeting;Antigens;Area;Autoimmunity;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Binding;Cardiovascular system;Cells;Cellular Structures;Communicable Diseases;Complex;Coronavirus;Data;Data Set;Development;Diagnostic;Disease;DNA;Effectiveness;Epitope Mapping;Epitopes;Event;experimental study;Foundations;Generations;Goals;Hematology;high throughput technology;High-Throughput Nucleotide Sequencing;HIV-1;Human;Immune;Immune response;Immune system;Immunodominant Antigens;Immunology;Individual;Infection;Libraries;Ligands;Light;Link;Malignant Neoplasms;Maps;Measures;Methods;Mining;Nervous System Disorder;new technology;next generation sequencing;novel;pathogen;Performance;Prevention;Process;Property;Resolution;Sampling;screening;single cell technology;Specificity;System;Technology;technology development;Therapeutic antibodies;therapeutic target;Time;Vaccines;Validation;virtual

PROJECT_TITLE: Technologies for High-Throughput Mapping of Antigen Specificity to B-Cell-Receptor Sequence


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Lupus is one of the top 10 leading causes of non-accidental death in adolescent females. Children and adolescents with lupus develop early blood vessel injury that significantly increases their risk of early heart attacks and strokes in adulthood. We currently do not know how to monitor or prevent these changes in childhood-onset lupus, which is more severe and confers greater cumulative tissue damage than adult-onset lupus. The proposed project seeks to determine whether blood pressure patterns and blood vessel function can be used to evaluate vascular health in children with lupus, and to assess whether medications used to prevent heart disease in other conditions may be beneficial in adolescents and young adults with lupus.

PI_NAMEs: CHANG, JOYCE CHUN-LING (contact)

PROJECT_TERMS: Acceleration;Accounting;Adolescent;Adolescent and Young Adult;Adult;Age;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;arterial tonometry;atheroprotective;Atherosclerosis;Attenuated;Blood Pressure;Blood Vessels;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;carotid intima-media thickness;cerebrovascular;Cessation of life;Child;Childhood;Chronic;clinical epidemiology;cohort;comorbidity;Cox Models;Data;Databases;Development;Disease;disorder control;Early identification;Electronic Health Record;endothelial dysfunction;Endothelium;Etiology;Event;experience;Female Adolescents;Fostering;Future;Glucocorticoids;Goals;Grant;Health;health assessment;heart disease prevention;high risk;Hypertension;Immunosuppression;improved;Infection;Inflammation;Injury;interdisciplinary collaboration;Intervention;Intervention Studies;Knowledge;longitudinal, prospective study;Lupus;Master of Science;Measures;Mediating;Mentors;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;Non-accidental;Obesity;Onset of illness;Outcome;Outcome Measure;Outcomes Research;patient oriented research;Patients;Pattern;Pediatric Hospitals;Pennsylvania;Peripheral;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Philadelphia;Physiological;premature;premature atherosclerosis;prevent;Prevention;professor;prospective;Recommendation;recruit;Renin-Angiotensin System;Reproducibility;Research;Research Personnel;Resources;Rheumatism;Rheumatology;Risk;Risk Factors;Risk Marker;risk stratification;Role;screening;secondary outcome;sex;Stroke;Systemic Lupus Erythematosus;Testing;Time;Tissues;Training;treatment response;Universities;Work;young adult

PROJECT_TITLE: Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult- onset disease

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Streptococcus agalactiae is the leading cause of neonatal sepsis and meningitis and an important pathogen in pregnant women and elderly patients. The proposed research has a potential to lead to the development of a novel drug selectively repressing the invasion state of Streptococcus agalactiae.

PI_NAMEs: KOROTKOVA, NATALIA  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Abbreviations;Adult;Agar;Antibiotic Prophylaxis;Antibiotic Resistance;Bacteria;Binding;Blood;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier disruption;Cell Separation;Central Nervous System;Chemicals;clinically relevant;Colon;Culture Media;Cytolysins;Detection;Development;Disease;Endothelium;Environment;Epithelium;Family;Folic Acid;gastrointestinal;Gene Expression;Genes;Genetic Screening;Genetic Transcription;genomic locus;Goals;Gram-Positive Bacteria;Group B Streptococcus colonization;gut microbiota;Hemolysin;Human;Immune;Immune Evasion;Immunocompromised Host;in vivo;Induction of Apoptosis;Infection;inhibitor;inorganic phosphate;intestinal epithelium;Invaded;Libraries;Lipids;Meningitis;metabolomics;microbiome;microbiota;microorganism;Mothers;mutant;Neonatal meningitis;neonatal sepsis;Newborn Infant;Niacinamide;novel;novel therapeutics;Nutrient;older patient;Oligopeptides;pathogen;Pathway interactions;Peptide Sequence Determination;Peptides;Phagocytes;Phagocytosis Induction;Pigments;Placenta;placental membrane;Pregnant Women;prevent;Preventive measure;Production;Proteins;quorum sensing;Regulation;Repression;Research;screening;Sepsis;Sequence Determination;Serum;Signal Transduction;Small Intestines;small molecule;Starch;Streptococcal Infections;Streptococcus Group B;System;Testing;Therapeutic;Toxin;transcriptome sequencing;transmission process;treatment group;Vaccines;vaginal microbiota;Virulence;Virulence Factors;Water;women patients;Work

PROJECT_TITLE: Genetic screen to define the regulation of beta-hemolysin toxin expression in Streptococcus agalactiae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Cancer is one of the leading causes of death in the U.S. and worldwide. Many conventional cancer treatments are often ineffective and cause substantial side effects. This study will identify ways to boost the effects of drugs called targeted therapies by combining them with a new type of therapy that activates immune cells to attack and eliminate cancer.

PI_NAMEs: WEISKOPF, KIPP A (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adenosine;Affect;Anti-CD47;anti-tumor immune response;Antibodies;arm;Binding;Biological Assay;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer therapy;cancer type;Cause of Death;CD47 gene;CD47-SIRPα;Cells;Clinic;Clinical Trials;Coculture Techniques;Combined Modality Therapy;Complement;curative treatments;Dichloromethylene Diphosphonate;Down-Regulation;Eating;effective therapy;Effector Cell;Engraftment;Evaluation;experimental study;Flow Cytometry;Genetic;Goals;Growth;Histologic;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunocompetent;Immunooncology;immunoregulation;Immunosuppression;In Vitro;in vivo;inhibitor;Innate Immune Response;Innate Immune System;Investigation;K-ras mouse model;KRAS2 gene;Ligands;Link;Liposomes;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Membrane Proteins;metabolomics;Modeling;mouse model;Mus;mutant;Mutation;Myelogenous;Neoplasm Metastasis;novel;Oncogenes;Oncogenic;Patients;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;precision medicine;PTPNS1 gene;receptor;side effect;Signal Transduction;Solid Neoplasm;success;Surface;synergism;targeted treatment;Testing;Therapeutic;Translating;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;Xenograft Model;Xenograft procedure

PROJECT_TITLE: KRAS inhibitors prime cancer cells for macrophage-mediated destruction


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Visual speech is helpful in real-world environments when access to acoustic speech is reduced by hearing loss. This project examines how hearing loss, and particularly frequency-specific audibility, influences benefit from visual speech among school-age children. Results will inform data-driven clinical recommendations regarding the best type of spoken language intervention for children with HL.

PI_NAMEs: LALONDE, KAYLAH L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: FACTORS INFLUENCING AUDIOVISUAL SPEECH BENEFIT IN CHILDREN WITH HEARING LOSS