NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: TOLAND, AMANDA EWART (contact)

PROJECT_TERMS: Abbreviations;Address;animal imaging;anti-cancer research;Appointment;arm;ATAC-seq;Biological Assay;biomedical informatics;Biometry;Blood capillaries;Body Fluids;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Research Project;Cancer Survivorship;Cell Line;Cells;Chemoprevention;Childhood;Chromium;clinical translation;Clinical Treatment;Clinical Trials;Comparative Pathology;Comprehensive Cancer Center;Copy Number Polymorphism;cost;Culicidae;Custom;Data;Development;Devices;Dideoxy Chain Termination DNA Sequencing;digital;digital imaging;DNA;DNA analysis;DNA copy number;DNA Sequence;Educational workshop;Engineering;Equipment;equipment acquisition;Flow Cytometry;Funding;Future;Gene Expression;Genetic Polymorphism;Genomic medicine;genomic profiling;Genomics;Genomics Shared Resource;Genotype;Grant;Growth;Immune;Immunologic Monitoring;Immunooncology;improved;insertion/deletion mutation;Institution;instrument;instrumentation;Intervention;Intramural Research Program;Laboratories;Labyrinth;Leadership;Left;leukemia;leukemia tissue bank;Libraries;Liquid substance;machine learning algorithm;Malignant Neoplasms;material transfer agreement;member;Messenger RNA;Metagenomics;metatranscriptomics;Methods;microbiome;Microscopy;Mission;Molecular;Molecular Carcinogenesis;Multiomic Data;nano-string;nanofluidic;National Cancer Institute;NCI Center for Cancer Research;Neoplasm Circulating Cells;new technology;next generation sequencing;Nucleic Acids;Nutrient;Ohio;pathology imaging;Pediatric Hospitals;Pharmaceutical Chemistry;Phytochemical;Polymerase Chain Reaction;Preparation;Procedures;programs;Proteomics;protocol development;Protocols documentation;Publications;recruit;Reproducibility;Research;Research Institute;Research Personnel;Research Priority;Resolution;Resource Sharing;Resources;RNA;RNA Splicing;Sampling;sequencing platform;Services;single cell genomics;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;Structure;Surveys;System;Technology;Transcript;transcriptome;transcriptome sequencing;transcriptomics;translational genomics;Translational Research;translational therapeutics;treatment response;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Shared Resource 08: Genomics (GSR)


ADMINISTERING_IC: EY

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE: A proinflammatory protein complex, the inflammasome, has been implicated in promoting choroidal neovascularization (CNV) in neovascular age-related macular degeneration (NV-AMD). Our findings in a mouse model of NV-AMD and in eyes of patients with NV-AMD suggest that the AIM2 inflammasome plays a key role in NV-AMD pathogenesis, which has previously not been examined. We will assess the roles of the AIM2 inflammasome in comparison to the NLRP3 inflammasome for the manifestation and disease progression of NV-AMD pathologies in well-established mouse models of this common eye disease.

PI_NAMEs: MARNEROS, ALEXANDER GEORG (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Affect;Age related macular degeneration;aged;Area;bevacizumab;CASP1 gene;cell injury;cell type;Cells;Cellular Stress;Cholesterol;Choroid;Choroidal Neovascularization;clinically relevant;Data;Disease;Disease Progression;Drug Targeting;ds-DNA;experimental study;Exudative age-related macular degeneration;Eye;Eye diseases;Generations;Genetic;Growth Factor;Human;Impairment;Infiltration;Inflammasome;Inflammatory;inhibitor;interest;Lasers;Lesion;Long-Term Effects;Macrophage;Microglia;Molecular;mouse model;Mus;new therapeutic target;novel strategies;novel therapeutics;Outcome;Oxidative Stress;Oxidative Stress Induction;pathogen;Pathogenesis;Pathologic Neovascularization;Pathology;Pathway interactions;patient subsets;Patients;Pattern recognition receptor;pharmacologic;Physiological;Play;pre-clinical;prevent;Production;protein complex;Publishing;Reactive Oxygen Species;Reporting;Research;Retina;Risk Factors;Role;side effect;Stimulus;Testing;Treatment Protocols;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Cellular and molecular mechanisms of AIM2 and NLRP3 inflammasome activation in age-related macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: ALINARI, LAPO  (contact)

PROJECT_TERMS: Abbreviations;Address;animal imaging;biobank;Biocompatible Materials;biomedical informatics;Biometry;Biopsy;Blood;bone;Bone Marrow;Budgets;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Survivorship;CD34 gene;Cell Survival;Chemoprevention;Clinic;Clinical;Clinical Data;Clinical Research Protocols;clinical translation;Clinical Treatment;Clinical Trials;Clip;Collaborations;Collection;Comparative Pathology;Comprehensive Cancer Center;Consent;Cryopreservation;Data;digital imaging;DNA;Electronics;Equipment and supply inventories;Evaluation;Experimental Hematology;Flow Cytometry;Fostering;Funding;Genetic;Genetic Materials;genomic data;Genomics;Germ Lines;Grant;Hematological Disease;Hematology;Hematopoietic stem cells;hip bone;Immune;Immunologic Monitoring;Immunooncology;Immunophenotyping;improved;Institution;Institutional Review Boards;Intervention;Intramural Research Program;Laboratories;Leukapheresis;leukemia;leukemia tissue bank;Liquid substance;Location;lymph nodes;Lymphoma;Marrow;material transfer agreement;member;Mentored Clinical Scientist Development Program;Microscopy;Molecular Carcinogenesis;Multiple Myeloma;NCI Center for Cancer Research;next generation sequencing;Nitrogen;Nutrient;Ohio;Oncology;Operative Surgical Procedures;Outcome;Pathologic;Pathology;pathology imaging;Patients;Pediatric Hospitals;Pharmaceutical Chemistry;Phenotype;Phytochemical;population based;Procedures;Process;programs;Proteins;Proteomics;Protocols documentation;Publications;Published Comment;Quality Control;recruit;Research;Research Institute;Research Personnel;Research Priority;Resource Sharing;Resources;sample collection;Sampling;senior faculty;Services;Source;standard of care;Stromal Cells;Structure of nail of finger;Surveys;System;Techniques;Tissue Procurements;translational genomics;Translational Research;translational therapeutics;Umbilical Cord Blood;Universities

PROJECT_TITLE: Shared Resource 09: Leukemia Tissue Bank (LTBSR)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS), is on the rise with a 50% increase in prevalence in the last decade. IL-17-producing T cells have a key role in driving destructive CNS tissue inflammation in MS. The proposed studies will advance our knowledge of the mechanisms that influence the ability of IL-17-producing T cells to cause damaging CNS tissue inflammation.

PI_NAMEs: ANDERSON, ANA C (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Anabolism;autoimmune inflammation;Automobile Driving;beta catenin;Biology;Bypass;Cells;Central Nervous System;Central Nervous System Diseases;clinically relevant;CNS autoimmunity;conditional knockout;Data;Defect;Development;Disease;Disease susceptibility;Enzymes;Epigenetic Process;epigenome;Gene Deletion;Genes;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Germ Lines;Glucocorticoid Receptor;Glucocorticoids;Granulocyte-Macrophage Colony-Stimulating Factor;Helper-Inducer T-Lymphocyte;Homeostasis;Human;IL17 gene;Impairment;in vivo;Inflammation;Inflammatory;insight;interleukin-23;Investigation;Knockout Mice;Knowledge;Link;Mature T-Lymphocyte;Mediating;Mediator;Modeling;Multiple Sclerosis;Mus;novel;novel therapeutic intervention;Pathogenicity;Patients;Predisposition;Prevalence;programs;Regulation;Relapse;Relapsing-Remitting Multiple Sclerosis;restraint;Role;Signal Transduction;Steroid biosynthesis;T-Cell Development;T-Lymphocyte;TCF Transcription Factor;Testing;Thymocyte Selection;Tissues;tool;transcriptome

PROJECT_TITLE: A TCF1:Glucocorticoid regulatory circuit controls IL-23-driven Th17 pathogenicity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Repair of alkylation damage to the genome is critical, because such damage is cytotoxic and potentially mutagenic. The proposed project has the potential to improve public health by elucidating the novel role of His phosphorylation in DNA alkylation damage repair (DAR) pathway and genome stability, which will eventually lead to overcome the challenge to using DNA-alkylating drugs more effectively and designing additional personalized treatments for cancer. The proposed work will utilize laboratory-based science to advance strategies for overcoming resistance to alkylating chemotherapy.

PI_NAMEs: PEI, HUADONG  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Adenine;Affect;Alkylating Agents;Alkylation;Biochemical;Biophysics;cancer cell;Cancer Patient;Castration;Cells;chemotherapy;Complex;Cytosine;cytotoxic;demethylation;design;detection method;DNA;DNA Alkylation;DNA Damage;Drug Design;Drug resistance;Drug usage;effective therapy;Event;Fibroblast Growth Factor Receptor 1;Generations;Genome;genome integrity;Genome Stability;Histidine;improved;In Vitro;in vivo;insight;Knock-out;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;Methylation;Modeling;Molecular;mouse model;multidisciplinary;Neuroendocrine Prostate Cancer;novel;Pathway interactions;patient derived xenograft model;Patients;personalized cancer therapy;Pharmaceutical Preparations;Phosphorylation;polyclonal antibody;Positioning Attribute;Post-Translational Protein Processing;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer cell line;Prostate Cancer therapy;protein-histidine kinase;Proteins;Public Health;recruit;Regulation;repaired;Research;Resistance;response;Role;Science;Signal Transduction;Single-Stranded DNA;Site;small molecule;Testing;tumor;Tyrosine;Tyrosine Phosphorylation;Work;Xenograft procedure

PROJECT_TITLE: The role of histidine phosphorylation in the DNA alkylation damage response

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Prevention

PI_NAMEs: PETERSON, BLAKE  (contact)

PROJECT_TERMS: Abbreviations;analog;animal imaging;base;Biological;Biology;biomedical informatics;Biomedical Research;Biometry;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer initiation;cancer prevention;Cellular Assay;Chemicals;Chemistry;Chemoprevention;clinical development;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;college;Comparative Pathology;Comprehensive Cancer Center;computational chemistry;Custom;design;Development;digital imaging;Discipline;drug development;Drug Targeting;equipment acquisition;Flow Cytometry;Funding;Genomics;Goals;Grant;Hour;Immunologic Monitoring;Immunooncology;improved;In Vitro;in vivo;Intervention;Intramural Research Program;Investments;Lead;lead optimization;Left;leukemia;leukemia tissue bank;Malignant Neoplasms;Medicine;member;Mentored Clinical Scientist Development Program;Microscopy;Molecular;Molecular Carcinogenesis;New Agents;novel;novel anticancer drug;novel therapeutics;Nutrient;Ohio;pathology imaging;Pathway interactions;Pediatric Hospitals;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacy facility;Phenotype;Phytochemical;pre-clinical;preclinical development;preclinical study;Preclinical Testing;Process;programs;Property;Proteins;Proteomics;Publications;recruit;Research;Research Institute;Research Personnel;Resource Development;Resource Sharing;screening;Services;small molecule;small molecule libraries;structural biology;Structure;Structure-Activity Relationship;Surveys;targeted agent;Therapeutic;translational genomics;Translational Research;translational therapeutics;tumor growth;tumor progression;Universities;Validation;Work

PROJECT_TITLE: Shared Resource 10: Medicinal Chemistry (MCSR)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PROJECT NARRATIVE In accordance with the goals of RFA-DK-21-004, the proposed project will examine the antigenic specificity of the anti-islet CD4+ memory T cell compartment in type 1 diabetic individuals. By testing the functional relevance of candidate autoantigens for β-cell destruction in pluripotent stem cell-derived islets, our studies will pave the way toward engineered, transplantable β-cells that can evade autoimmune rejection.

PI_NAMEs: TEYTON, LUC  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: advanced disease;Antibodies;Antigen Presentation;Antigenic Specificity;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Autologous;Autologous Transplantation;Automobile Driving;B-Lymphocytes;Beta Cell;Biological Assay;C-Peptide;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Line;Cell Therapy;Cells;Cellular Assay;Cellular biology;Clinical;Coculture Techniques;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Disease Progression;Engineering;Engraftment;Epitope spreading;Epitopes;experimental study;Genes;Genotype;Goals;Graft Rejection;Haplotypes;high reward;high risk;Histocompatibility Antigens Class II;HLA Antigens;HLA-DQ8 antigen;Human;human induced pluripotent stem cells;humanized mouse;Immune;Immune system;Immunologic Memory;Immunologist;In Vitro;Inbred NOD Mice;Individual;induced pluripotent stem cell;innovation;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Knowledge;Mediating;Memory;memory CD4 T lymphocyte;Minor;Modeling;monocyte;mouse model;Mus;Nature;non-diabetic;peripheral blood;Persons;Play;Pluripotent Stem Cells;Pre-Clinical Model;prevent;response;Role;single cell analysis;Source;Specificity;Study models;Subgroup;System;T cell receptor repertoire sequencing;T cell response;T memory cell;T-cell diversity;T-Lymphocyte;Technology;Testing;Therapeutic;Time;tool;translational impact;Transplantation;type I diabetic;Variant

PROJECT_TITLE: Leveraging Human iPSC-derived beta-cells to Probe Antigen Specificity of Anti-islet Memory T Cells in T1D


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: GAINESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative The proposed research aims to identify and functionally characterize in situ pancreatic islet neoantigens and neoepitopes formed through protein posttranslational modifications under the conditions pre-type 1 diabetes and type 1 diabetes. The novel functional in situ neoepitopes confirmed from human patients and neoepitope- reactive T cells will provide novel biomarkers for type 1 diabetes and important mechanistic insights into the initiation of type 1 diabetes to guide prevention strategies for at-risk individuals.

PI_NAMEs: MATHEWS, CLAYTON E (contact);OSTROV, DAVID A;QIAN, WEI-JUN

PROJECT_TERMS: Affinity;Alleles;alpha-beta T-Cell Receptor;Autoantibodies;Autoantigens;Autoimmune Diseases;autoreactive T cell;Beta Cell;Binding;Biological Markers;Blood;candidate identification;CD3 Antigens;Cells;Complex;Cysteine;Databases;deamidation;Disease;Epitopes;Exhibits;Guide prevention;Human;Hybrids;Immune;Immune mediated destruction;Immune Tolerance;Immunofluorescence Immunologic;Immunology;In Situ;In Vitro;Individual;Inflammation;Inflammatory;innovation;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;interest;Intervention;islet;Islets of Langerhans;Lasers;Mass Spectrum Analysis;Mediating;Microdissection;Modeling;molecular modeling;nanoDroplet;neoantigens;novel;novel marker;oxidation;Pancreas;Patients;Peptides;Phosphorylation;Play;Population;Positioning Attribute;Post-Translational Protein Processing;predictive modeling;preproinsulin;Prevention;Prevention strategy;Process;Production;Proinsulin;protein aminoacid sequence;Proteins;Proteolytic Processing;Proteome;Proteomics;Reagent;Reporting;Research;Resources;Risk;risk variant;Role;Sampling;Slice;Specific qualifier value;Specificity;Stress;Structure of beta Cell of islet;System;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Tissues;Translating

PROJECT_TITLE: Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes


PI_NAMEs: STOODLEY, PAUL  (contact)

PROJECT_TERMS: Abbreviations;Address;Advertising;animal imaging;anti-cancer research;Applications Grants;Area;Award;biomedical informatics;Biomedical Research;Biometry;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Survivorship;Cells;cellular imaging;Cellular Structures;Chemoprevention;Collaborations;college;Communities;Complex;Comprehensive Cancer Center;Consultations;cost effective;Cost Sharing;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Diagnostic;Education;Educational workshop;Electron Microscope;Electron Microscopy;Electrons;Engineering;Equipment;experience;Flow Cytometry;Fluorescence;Fresh Tissue;Funding;Funding Mechanisms;Genomics;Grant;high resolution imaging;Hour;Image Analysis;imaging capabilities;imaging platform;Imaging Techniques;Immunologic Monitoring;Immunooncology;improved;Institution;instrument;instrumentation;Intramural Research Program;Investments;Ions;Leadership;leukemia;leukemia tissue bank;light microscopy;live cell imaging;live cell microscopy;Malignant Neoplasms;Manuscripts;member;Methods;Microscope;Microscopy;Minor;Molecular Carcinogenesis;multi-photon;multiphoton microscopy;nanometer resolution;NCI Center for Cancer Research;new technology;Ohio;Optics;particle;Pediatric Hospitals;Peer Review;Pharmaceutical Chemistry;Physicians;Preparation;Process;programs;Publications;Published Comment;reconstruction;recruit;Research;Research Institute;Research Personnel;Resolution;Resource Sharing;Resources;Role;Sampling;Scanning;Scanning Electron Microscopy;Scientist;Services;single cell sequencing;single molecule;Supporting Cell;Techniques;Technology;Time;Tissues;Training;Training Support;translational genomics;translational therapeutics;Transmission Electron Microscopy;transmission process;two-photon;ultra high resolution;United States National Institutes of Health;Universities;Update;Wages

PROJECT_TITLE: Shared Resource 11: Microscopy (MSR)


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Dopaminergic neurons are comprised of diverse subsets, and declines in these critical cells contribute to many mental illnesses and neurological disorders. However, the mechanisms responsible for generating and maintaining dopamine neuron diversity are not well mapped. In this project, we examine how a specific kinase pathway programs the numbers, diversity, and connectivity of dopamine neurons with the long-term goal of preserving these cells to improve outcomes in dopamine-regulated mental illnesses and disease.

PI_NAMEs: ARENKIEL, BENJAMIN R;SAMUEL, MELANIE A (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adopted;Basic Science;Biochemical;Biological Assay;Biology;Brain;Brain region;Catecholamines;cell type;Cells;Coupling;Data;Development;Diabetic Retinopathy;Disease;disease model;Dopamine;Dopaminergic Cell;dopaminergic neuron;Endowment;Etiology;Eye;gain of function;Generations;Genetic;Goals;Histologic;improved outcome;inhibitory neuron;interest;Interneurons;Lead;Location;loss of function;Maps;Mediating;Mental disorders;Midbrain structure;Molecular;Molecular Target;Mus;mutant;nerve stem cell;Nervous System Disorder;neural;neurogenetics;Neuromodulator;neuron development;neuron loss;Neurons;neuroregulation;novel;novel therapeutics;Parkinson Disease;Pathology;Pathway interactions;Pattern;Phosphotransferases;Play;Population;preservation;Production;programs;Property;Protein-Serine-Threonine Kinases;Public Health;Regulation;Retina;Role;Signal Transduction;Specific qualifier value;STK11 gene;Substantia nigra structure;System;temporal measurement;Testing;Time;transcriptomics;Ventral Tegmental Area;Viral;Vision;Visual;Visual System;Work

PROJECT_TITLE: Molecular specification of dopaminergic neuron diversity

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: LINCOLN

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Human gut microbes primarily feed on carbohydrate substrates derived from diet and host, and produce important metabolites that significantly influence host physiology and health. The functional annotation of the carbohydrate metabolic enzyme repertoire of gut microbes is poorly defined for most bacterial phyla, resulting in gaps in understanding of how microbial communities utilize these carbohydrates to influence human health. Creating new bioinformatics tools for predicting carbohydrate utilization will contribute to the arising microbiome-based personalized nutrition practice and aid in the development of therapeutic options to prevent/treat human metabolic disorders.

PI_NAMEs: YIN, YANBIN  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Algorithms;annotation  system;Bacterial Genome;Bacteroidetes;Bioinformatics;bioinformatics tool;Carbohydrates;Classification;computer program;computerized tools;contig;Data;Databases;Development;Diet;dietary;Dietary Fiber;Environment;Enzymes;experience;Family;Firmicutes;Food;Foundations;Gene Cluster;Genes;genetic element;Genome;Genomics;Glucans;gut metagenome;gut microbes;gut microbiome;Health;Health Food;host microbiota;Human;Human Microbiome;innovation;interest;Learning;Link;Literature;Machine Learning;machine learning method;Mannans;Maps;Medicine;Metabolic;Metabolic Diseases;metagenome;metatranscriptome;Microbe;microbial;microbial community;microbial genome;microbiome;microbiome sequencing;Nebraska;novel;open source;Other Genetics;Outcome;Pectins;personalized nutrition;Persons;Physiology;Polysaccharides;prebiotics;predictive tools;prevent;programs;Proteins;Proteobacteria;Publishing;Research;Research Personnel;Sampling;Signaling Protein;Starch;sugar;supervised learning;System;Testing;therapeutic development;tool;tool development;Training;unsupervised clustering;user-friendly;web server;Work;Xylans

PROJECT_TITLE: Carbohydrate enzyme gene clusters in human gut microbiome

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences;Therapeutic Cannabinoid Research

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Endocannabinoids are lipid signaling molecules within the brain that regulate neurotransmission and synaptic strength. This study seeks to demonstrate that fatty acid binding proteins are synaptic carriers for endocannabinoids at central synapses and regulate retrograde endocannabinoid signaling. The outcome of this study will greatly improve our understanding of endocannabinoid signaling and may lead to novel therapeutic strategies to treat psychiatric and neurological disorders.

PI_NAMEs: HAJ-DAHMANE, SAMIR  (contact);KACZOCHA, MARTIN

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 2-arachidonylglycerol;Address;Anabolism;Anxiety;aqueous;Area;Astrocytes;autism spectrum disorder;Behavioral;Biochemical;Biology;Brain;brain dysfunction;Brain region;cannabinoid receptor;Carrier Proteins;Cells;CNR1 gene;cognitive reappraisal;Cytosol;Development;Diffusion;Disease;dorsal raphe nucleus;Electrophysiology (science);emotion regulation;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Engineering;Enzymes;Excitatory Synapse;FABP5 gene;Family;fatty acid-binding proteins;Functional disorder;Future;gamma-Aminobutyric Acid;Genetic;genetic approach;Glutamates;Hippocampus;Hydrophobicity;improved;Inhibitory Synapse;Knockout Mice;lipid transport;Lipids;lipophilicity;LoxP-flanked allele;Mediating;Mental Depression;Mental disorders;Mus;Nature;Nervous System Disorder;Neurons;neurotransmission;neurotransmitter release;new therapeutic target;novel;novel therapeutic intervention;Outcome Study;Output;Pathologic;pharmacologic;Physiological;Play;Population;Positioning Attribute;postsynaptic neurons;presynaptic;Presynaptic Terminals;Process;Proteins;Psychiatric therapeutic procedure;Receptor Activation;Reporting;Role;Signal Transduction;Signaling Molecule;Solubility;Synapses;Synaptic Cleft;synaptic function;Synaptic plasticity;Synaptic Transmission;Testing;therapeutic target;therapy development;Variant;Ventral Tegmental Area;Viral

PROJECT_TITLE: Synaptic transport of endocannabinoids in the brain

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Prevention;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CLINTON, STEVEN K (contact)

PROJECT_TERMS: Abbreviations;absorption;Agriculture;Animal Experiments;animal imaging;anti-cancer;base;Biological;Biological Assay;Biological Markers;biomedical informatics;Biometry;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Etiology;Cancer Hospital;cancer prevention;cancer risk;Cancer Survivorship;Carcinogens;Cell Culture Techniques;Chemoprevention;clinical translation;Clinical Treatment;Clinical Trials;Clinical Trials Network;Collaborations;college;Comparative Pathology;Comprehensive Cancer Center;Diet;Dietary Practices;digital imaging;Discipline;drug development;Environmental Science;Epidemiology;Excretory function;Faculty;Flow Cytometry;Food;Food Patterns;food science;food science/technology;Funding;Future;Genetic Determinism;Genomics;Grant;Growth;High Pressure Liquid Chromatography;Human;Immunooncology;improved;In Vitro;in vivo;Individual;Informatics;innovation;insight;Institution;instrument;instrumentation;Intake;Intervention;Intramural Research Program;Investigational Therapies;Investments;ion mobility;Laboratories;leukemia;leukemia tissue bank;lipidomics;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;member;Metabolism;metabolomics;method development;microbiome;Microscopy;Mission;Molecular Carcinogenesis;Molecular Epidemiology;NMR Spectroscopy;novel;Nutrient;Ohio;pathology imaging;Pathway Analysis;Pediatric Hospitals;Pharmaceutical Chemistry;Phytochemical;Preparation;Prevention;programs;Proteomics;Publications;Published Comment;recruit;Reporting;Research;Research Institute;Research Personnel;Research Support;Resource Sharing;Role;Sampling;Schedule;senior faculty;Services;Source;Supercritical Fluid Chromatography;Surveys;survivorship;Techniques;Technology;Tobacco;tobacco exposure;Tobacco use;Training;translational genomics;Translational Research;translational scientist;translational therapeutics;Universities;Validation

PROJECT_TITLE: Shared Resource 12: Nutrient and Phytochemical Analytics (NPASR)


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narratives  The goal of this proposal is to determine how the increased expression of a small noncoding RNA miR- 182-5p in the front part of human eyes contribute to elevated eye pressure and glaucoma risk. Eye pressure is the major and only treatable risk factor with glaucoma patients in the clinic. The successful completion of this project will help uncover critical information on the specific roles of miR-182-5p and its molecular targets in regulating eye pressure and provide new treatment targets to lower eye pressure more effectively in glaucoma patients.

PI_NAMEs: LIU, YUTAO  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Achievement;Affect;Anatomy;Anterior;aqueous;Aqueous Humor;Blindness;cancer cell;Cell Aging;Cell Count;Cell Death;Cell Physiology;Cells;CHEK2 gene;Clinic;Clinical Treatment;comparison control;Complementary DNA;contrast enhanced;Data;Development;differential expression;Disease;DNA cassette;Endothelial Cells;Eye;Female;Fibrosis;FOXO1A gene;Gel;Gene Expression;Genes;Genetic Transcription;Glaucoma;Goals;high intraocular pressure;Histology;Human;in silico;In Vitro;in vivo;innovation;Knowledge;male;Mass Spectrum Analysis;Mechanics;MicroRNAs;Molecular Target;Monitor;MRI Scans;multiple reaction monitoring;Mus;Mutation;Nerve Fibers;new therapeutic target;Ocular Hypertension;Optic Disk;overexpression;particle;Pathogenesis;Pathway interactions;Patients;Periodicity;Phagocytosis;Phagocytosis Inhibition;pharmacologic;Physiologic Intraocular Pressure;Physiological Processes;Play;premature;pressure;prevent;Primary Open Angle Glaucoma;promoter;Proteins;Proteomics;Regulation;Reporting;Research;Retina;Retinal Degeneration;Retinal Ganglion Cells;Risk;Risk Factors;risk variant;Role;senescence;single nucleus RNA-sequencing;Stains;Stretching;Structure of sinus venosus of sclera;therapeutic target;three dimensional cell culture;Time;Tissues;Trabecular meshwork structure;Training;transcriptome sequencing;Transforming Growth Factor beta;Transgenic Mice;Untranslated RNA;Visual Fields

PROJECT_TITLE: MIR182 and Ocular Hypertension.

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative  Optical imaging instruments have permeated medical practice because of their ease of use, rapid adaptation to clinical needs, portability, real-time feedback, and relatively low cost. We have developed a wearable head- mounted display device that is augmented by visible and near-infrared fluorescence imaging of tissues in real- time. In collaboration with an industry partner, we will optimize the device performance and ergonomics using human factors engineering. Successful completion of the research will accelerate its clinical translation and adoption in both high- and low-resource communities.

PI_NAMEs: ACHILEFU, SAMUEL  (contact);BURAS, WILLIAM ROBINSON

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Address;Adoption;Algorithms;Animal Cancer Model;Area;Augmented Reality;Beds;Biological;Blood flow;Breast-Conserving Surgery;Calibration;cancer cell;cancer imaging;Cancer Patient;cancer recurrence;cancer surgery;clinic ready;Clinical;clinical center;Clinical Research;clinical translation;Collaborations;Color;Computer software;Consumption;cost;Data;Decision Making;design;Development;Devices;Digital Imaging and Communications in Medicine;Disease;Dyes;Engineering;Ensure;ergonomics;Evaluation;Excision;experience;Feedback;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Frozen Sections;Goals;Goggles;Growth;Head and neck structure;head mounted display;Histology;Hospitals;Human;Image;image processing;image registration;Image-Guided Surgery;Imaging Device;imaging system;improved;Incidence;industry partner;infiltrating duct carcinoma;Infiltration;Infrastructure;interest;Intervention;Intuition;Left;lens;Lesion;Machine Learning;Malignant Neoplasms;Medical;Medical center;Medical Device;Metadata;Methods;Microscopic;mixed reality;Molecular Probes;Molecular Target;Near-infrared optical imaging;Neck Cancer;neoplastic cell;Noninfiltrating Intraductal Carcinoma;Oncology;Operating Rooms;operation;Operative Surgical Procedures;optical imaging;Optical Methods;Optics;Outcome;Pathology;Pathology Report;Patient-Focused Outcomes;Patients;Pattern;Performance;peripheral blood;phantom model;Pilot Projects;portability;prevent;radiological imaging;Real-Time Systems;Reporting;Reproducibility;Research;Resource-limited setting;Resources;Role;Rural;Rural Hospitals;software development;Solid Neoplasm;Specimen;standard of care;stem;Stream;Surgeon;Surgical margins;Surgical Oncology;System;Tactile;Testing;Thick;Time;Tissue imaging;Tissues;Training;Treatment outcome;tumor;user-friendly;Vision;Visual;Visual Fields;Visualization;wearable device;workforce needs

PROJECT_TITLE: Imaging Goggles for Fluorescence-Guided Surgery


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: PHELPS, MITCH A (contact)

PROJECT_TERMS: Abbreviations;animal imaging;Antineoplastic Agents;assay development;Biological;Biological Assay;Biological Products;biomedical informatics;Biomedical Research;Biometry;Biopsy;Bone Marrow Aspiration;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer therapy;Chemoprevention;Clinical;clinical decision-making;clinical development;Clinical Protocols;clinical translation;Clinical Treatment;Clinical Trials;Clinical Trials Network;Comparative Pathology;Complex;Comprehensive Cancer Center;Data;Data Analyses;design;Development;digital imaging;Dose;Drug Delivery Systems;drug development;Drug Kinetics;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Experimental Designs;Flow Cytometry;Funding;Future;Genomics;Grant;Growth;Histone Deacetylase;Immunologic Monitoring;Immunooncology;Immunotherapy;Institution;instrumentation;Intervention;Intramural Research Program;Investigational Therapies;investigator-initiated trial;leukemia;leukemia tissue bank;liquid chromatography mass spectrometry;Malignant Neoplasms;Measurement;member;Methods;Microscopy;Mission;models and simulation;Molecular Carcinogenesis;Neoplasm Circulating Cells;new technology;novel;Nutrient;Ohio;oligonucleotide therapeutics;Organ;pathology imaging;Pediatric Hospitals;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacology;Phase;Phytochemical;pre-clinical;preclinical development;programs;Proteomics;Publications;Recommendation;recruit;Regimen;Research;Research Design;Research Institute;Research Personnel;Resistance;Resource Sharing;Sampling;Service delivery model;Services;small molecule;Specimen;Statistical Models;Surveys;System;targeted delivery;Technology;therapy development;Time;translational genomics;Translational Research;translational scientist;translational therapeutics;tumor;United States Food and Drug Administration;Universities;Validation

PROJECT_TITLE: Shared Resource 13: Pharmaco Analytical (PhASR)


PI_NAMEs: FREITAS, MICHAEL A. (contact)

PROJECT_TERMS: Abbreviations;Address;advanced analytics;Alternative Splicing;Area;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;Bronchoalveolar Lavage Fluid;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer imaging;cancer prevention;cancer proteomics;Cancer Survivorship;Capillary Electrophoresis;Categories;Cell Culture Techniques;Cells;Chemicals;Chemoprevention;college;Complex;Comprehensive Cancer Center;Computer software;Consultations;Core Facility;Cryo-electron tomography;Culture Media;Data Analyses;Data Analytics;Data Set;Detection;Development;Device or Instrument Development;Devices;differential expression;Drops;Electron Microscopy;Engineering;Equipment;experience;Experimental Designs;experimental study;Flow Cytometry;Fluorescence;Formalin;Freezing;Funding;Genomics;Grant;High Pressure Liquid Chromatography;Immunologic Monitoring;Immunooncology;improved;Informatics;innovation;Institution;instrument;instrumentation;Intramural Research Program;ion mobility;Label;Leadership;leukemia;leukemia tissue bank;light microscopy;Liquid substance;Malignant Neoplasms;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;member;method development;Methods;Microscopy;Molecular Carcinogenesis;Mutation;NCI Center for Cancer Research;new technology;novel;Ohio;operation;Optics;Pediatric Hospitals;Peptide Sequence Determination;Pharmaceutical Chemistry;Post-Translational Protein Processing;Preparation;Price;programs;Protein Analysis;protein crosslink;protein expression;protein protein interaction;Protein Truncation;Proteins;Proteomics;Proteomics Shared Resource;Publications;Published Comment;reconstruction;recruit;Research;Research Institute;Research Personnel;Research Priority;Resource Sharing;Resources;S10 grant;Saliva;Sampling;Scanning Electron Microscopy;senior faculty;Serum;Services;Site;software development;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stable Isotope Labeling;structural biology;Techniques;Time;timeline;tissue fixing;Tissue imaging;Tissues;Training;translational genomics;translational therapeutics;Transmission Electron Microscopy;United States National Institutes of Health;Universities;Urine;Variant;Work

PROJECT_TITLE: Shared Resource 14: Proteomics (PSR)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative The T32 Program ‘Promoting Academic Workforce Diversity in Translational Behavioral and Cardio- Metabolic Research-PINNACLE’ at the University of Miami will train, mentor, and sustain a network of 12 underrepresented minority post-doctorate mentees committed to developing independent academic careers in translational and behavioral cardiovascular health research. This will have a strong impact in achieving the national mandate (Healthy People 2030) to increase diversity in the academic workforce, thus expanding capacity to implement translational models to improve health quality and equity.

PI_NAMEs: JEAN-LOUIS, GIRARDIN  (contact);RUNDEK, TATJANA

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Behavioral;cardiometabolism;Research

PROJECT_TITLE: Promoting Academic Workforce Diversity in Translational Behavioral & Cardio-Metabolic Research (PINNACLE)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Mental Health;Methamphetamine;Neurodegenerative;Neurosciences;Opioids;Pain Research;Palliative Care;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH

PHR: Project Narrative This project will support the candidate’s development as a mentor in patient-oriented substance use research by providing protected time for advanced training in implementation science, ecological momentary assessment, adaptive trial design, pain research, mentoring faculty-level mentees, developing a training for mentors in mentoring through differentness, and supporting a novel study of non-prescribed stimulant use for neuropathic pain among people living with HIV.

PI_NAMEs: COFFIN, PHILLIP O (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Absence of pain sensation;Acceleration;Affect;Animals;Behavior Therapy;Benefits and Risks;career;Caring;Characteristics;chronic pain;chronic pain patient;clinical practice;Cocaine;cohort;Data;Data Set;Development;Disease;Ecological momentary assessment;Enrollment;Event;experience;experimental study;faculty mentor;Failure;Female;Funding;Gender;Healthcare Systems;Heroin;HIV;Hour;Human;implementation science;improved;Intervention;Interview;Longitudinal cohort study;Mental Health;Mentors;Methamphetamine;methamphetamine effect;Methamphetamine overdose;methamphetamine use;Mid-Career Clinical Scientist Award (K24);Modeling;Morbidity - disease rate;mortality;Motivation;Naloxone;National Institute of Drug Abuse;Neuropathy;non-cancer chronic pain;novel;novel strategies;older adult;Opioid;Opioid Analgesics;opioid use;Overdose;overdose death;Pain;Pain intensity;Pain management;Pain Nature;Pain Research;painful neuropathy;Palliative Care;Participant;patient oriented;patient oriented research;Patients;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;pharmacologic;pleasure;Poisoning;poor health outcome;Postoperative Period;prescription opioid;Primary Care;Qualitative Methods;Reading;reduced substance use;Reporting;Research;Research Personnel;response;Rewards;Risk;San Francisco;Science;Self Care;Self Management;social;Social isolation;Source;Stimulant;stimulant use;substance use;suicide mortality;Time;Toxic effect;Training;transmission process;trial design;viral transmission;Voice

PROJECT_TITLE: Midcareer K24 Award for Mentoring and Patient-Oriented Research

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Precision Medicine;Primary Health Care;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Despite growing evidence supporting the effectiveness of medications for opioid use disorder (MOUD), access to these medications is still insufficient, with most patients remaining untreated. Therefore, enhancing knowledge about real-world effectiveness and guiding optimal use of MOU D in the clinical care of patients is of critical importance. The proposed studies, by leveraging electronic medical records from the Veterans Affairs, state-of-the-art data models, machine learning algorithms and causal inference methods, provide a timely and unique opportunity to close these knowledge gaps and answer a set of timely questions centering around OUD care.

PI_NAMEs: LU, HAIDONG  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adopted;Affect;Algorithms;American;Behavior;Big Data Methods;Buprenorphine;career;career development;Caring;Characteristics;Clinic;Clinical;clinical care;Clinical effectiveness;Clinical Management;Communicable Diseases;Complex;Computerized Medical Record;Data;Data Analytics;data modeling;Data Science;Databases;Development Plans;Diagnosis;Disease remission;Doctor of Philosophy;Dose;Dropout;Effectiveness;effectiveness evaluation;Epidemiologist;Epidemiology;Evaluation;evidence base;Failure;FDA approved;Fruit;Gills;Goals;high dimensionality;HIV;HIV Infections;HIV Seropositivity;HIV/AIDS;improved;Individual;individual patient;Information Systems;Insurance Coverage;Integrated Health Care Systems;Intervention;Knowledge;Learning;Machine Learning;machine learning algorithm;machine learning method;medical specialties;medication for opioid use disorder;Mentorship;Methadone;methadone treatment;Methods;microbial disease;Modeling;mortality;multidimensional data;multidisciplinary;Naltrexone;North Carolina;Opioid;opioid overdose;opioid use;opioid use disorder;optimal treatments;Outcome;Patient Care;patient population;Patients;Periodicity;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Postdoctoral Fellow;Prediction of Response to Therapy;primary care clinic;primary care setting;Public Health;Public Health Schools;Recovery;Research;Research Personnel;Research Proposals;Sample Size;Schools;Science;Scoring Method;skills;Space Models;Stochastic Processes;Structure;structured data;study population;Subgroup;substance use;Techniques;theories;Time;Training;treatment program;treatment strategy;United States;United States Department of Veterans Affairs;Universities;Veterans Health Administration;Viral

PROJECT_TITLE: Evaluating and Optimizing Care for Opioid Use Disorder using a Structured Data-Science Approach


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: NAUGHTON, MICHELLE J. (contact)

PROJECT_TERMS: Abbreviations;Abnormal coordination;Adoption;animal imaging;Applications Grants;arm;behavior measurement;Behavioral Research;biomedical informatics;Biometry;Biostatistics Shared Resource;Budgets;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer health equity;Cancer Hospital;cancer prevention;Cancer Survivorship;Catchment Area;Cellular Phone;Chemoprevention;Clinical Informatics;Clinical Investigator;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Collection;Communication;community engagement;Community Outreach;Comparative Pathology;Comprehensive Cancer Center;Computers;Contracts;cost;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;data sharing networks;Data Storage and Retrieval;Development;digital imaging;disparity reduction;eHealth;electronic data;Electronic Health Record;Electronics;Ensure;Epidemiology;epidemiology study;Faculty Recruitment;flexibility;Flow Cytometry;Focus Groups;Funding;Genomics;Goals;Grant;Health Services Research;human data;Immunologic Monitoring;Immunooncology;Individual;informatics shared resource;Institution;Institutional Review Boards;instrumentation;Intervention;Intervention Studies;Intramural Research Program;leukemia;leukemia tissue bank;Malignant Neoplasms;Measures;member;Mentored Clinical Scientist Development Program;Methods;mhealth interventions;Microscopy;minority patient;mobile application;Molecular Carcinogenesis;Names;NCI Center for Cancer Research;new technology;Nutrient;Ohio;Participant;participant retention;pathology imaging;Patient Outcomes Assessments;Patient Recruitments;Pediatric Hospitals;Persons;Pharmaceutical Chemistry;Phytochemical;Population;population based;Population Sciences;Principal Investigator;Procedures;programs;Proteomics;Publications;Qualitative Research;recruit;Registries;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;research study;Resource Sharing;Scientist;Services;Surveys;System;Target Populations;Telephone Interviews;Text Messaging;Translational Research;translational therapeutics;Underrepresented Minority;underserved minority;Universities;wireless;Work;working group

PROJECT_TITLE: Shared Resource 15: Recruitment, Intervention, and Survey (RISSR)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: ORANGE

ORG_NAME: CHAPMAN UNIVERSITY

PHR: Narrative Graft versus host disease (GVHD) is a serious complication of allogeneic bone marrow transplantation affecting many organs including the eyes causing ocular surface damage, conjunctival and lacrimal fibrosis and severe dry eye. The current proposal will investigate the role of host and donor origin macrophages and their interaction with fibroblasts and goblet cells in the pathogenesis of ocular GVHD. These studies can potentially lead to new therapies that target macrophages to treat or prevent GVHD-associated conjunctival and lacrimal gland fibrosis and dry eye.

PI_NAMEs: SHARMA, AJAY  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;Affect;Allogeneic Bone Marrow Transplantation;Antigens;Area;Attenuated;Binding;Biological;Bone Marrow;Bone Marrow Transplantation;Categories;Cell Proliferation;Cells;chemokine;chemotherapy;Chimerism;Chronic;chronic graft versus host disease;Chronic Phase;Complication;conditioning;conjunctiva;Cornea;Data;disorder control;Environmental Exposure;Excision;Exhibits;Eye;eye dryness;Fibroblasts;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression;Genes;Goals;Goblet Cells;graft vs host disease;Hematopoietic Stem Cell Transplantation;Immune;Immunologist;Immunology;Immunophenotyping;Incidence;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Interleukin-13;irradiation;Keratopathy;Knowledge;lacrimal;Lacrimal gland structure;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Marrow;Mediating;Mediator;Modeling;Morbidity - disease rate;mouse model;Mucins;Mucous Membrane;Mus;Myofibroblast;nano-string;new therapeutic target;novel therapeutic intervention;ocular surface;Organ;paracrine;Pathogenesis;Pathology;Pathway interactions;Patients;Perforation;pharmacologic;Phenotype;Positioning Attribute;prevent;Prevention;profibrotic cytokine;receptor;recruit;Refractory;Role;Sampling;Sentinel;Steroids;Stimulus;Surface;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;tissue injury;Tissues;transdifferentiation;Visual;wound healing

PROJECT_TITLE: Role of Macrophages in ocular GVHD


PI_NAMEs: POWELL, KIMERLY ANN (contact)

PROJECT_TERMS: Abbreviations;Address;Animal Cancer Model;animal imaging;Animals;Autopsy;biomedical informatics;Biomedical Research;Biometry;Body Composition;Breast;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Hospital;Cancer Model;cancer prevention;Cancer Survivorship;cancer therapy;Chemoprevention;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;college;Comparative Pathology;Complex;Comprehensive Cancer Center;Computer software;Consultations;Data Analyses;digital imaging;Disease Progression;Emerging Technologies;Engineering;Equipment;ex vivo imaging;Experimental Animal Model;Flow Cytometry;Frequencies;Funding;Genetically Engineered Mouse;Genomics;Glioblastoma;Grant;high resolution imaging;Hour;Human Resources;IACUC;Image;Image Analysis;imaging capabilities;imaging facilities;imaging modality;Imaging technology;Immunologic Monitoring;Immunooncology;in vivo;infrared spectroscopy;Institution;instrumentation;Intervention;Intramural Research Program;Left;leukemia;leukemia tissue bank;Lung;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Medicine;member;Metastatic Neoplasm to the Lung;microCT;microscopic imaging;Microscopy;Modality;Molecular Carcinogenesis;molecular imaging;Monitor;Mus;new technology;Nutrient;Ohio;operation;Optics;Pancreas;pancreatic neoplasm;Pathology;pathology imaging;Pharmaceutical Chemistry;photoacoustic imaging;Phytochemical;Policies;Positron-Emission Tomography;preclinical imaging;Price;Procedures;programs;Proteomics;Protocols documentation;Publications;quantitative imaging;Radiation;recruit;Research;Research Institute;Research Personnel;Research Priority;Resolution;Resource Sharing;Resources;response;Roentgen Rays;senior faculty;Services;Small Animal Imaging Shared Resource;Surveys;Techniques;therapeutic development;Therapeutic Intervention;Time;Tissue Sample;Training;Training and Education;translational genomics;Translational Research;translational therapeutics;Tumor Burden;tumor progression;ultrasound;Universities;Validation;Vision;Work

PROJECT_TITLE: Shared Resource 16: Small Animal Imaging (SAISR)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Cancers of the gastrointestinal and gynecologic tracts (GI/GYN) cause of US cancer deaths. The goal of this proposal is to improve QOL in patients with advanced GI/GYN cancers, decrease patient and family caregiver distress, and reduce health care use by improving symptom management and skills training.

PI_NAMEs: WRIGHT, ALEXI A (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: acceptability and feasibility;Advanced Malignant Neoplasm;Affect;Ascites;Biliary;biliary tract;bilingualism;Bladder;cancer care;Cancer Center;Cancer Etiology;Cancer Patient;care fragmentation;care systems;Caregiver Burden;Caregiver support;Caregivers;Caring;Catheters;Cementation;Cervical;Cessation of life;chronic care model;Clinical;Community Clinical Oncology Program;Complex;coping;Devices;Discipline of Nursing;Distress;Education;efficacy evaluation;electronic patient reported outcomes;empowerment;end of life;Ensure;ethnic diversity;ethnic minority population;Family;Family Caregiver;feeding;Fistula;Goals;health care service utilization;Healthcare;high risk;Home;hospice environment;hospital patient care;hospital readmission;Hospitalization;Hospitals;Immigrant;implementation facilitators;implementation trial;improved;innovation;Intervention;Intestinal Obstruction;Intestines;Invaded;Latino;Latino Population;Lead;Learning;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Managed Care;Mediating;Medical;mHealth;Minority Groups;Modeling;Monitor;Neoplasm Metastasis;non-healing wounds;Nurses;Obstruction;Office Visits;Oncology;Operative Surgical Procedures;Organ;Ostomy;Pain;palliate;Palliative Care;participant enrollment;Patients;Pelvis;Peritoneal;Peritoneum;Phase;Pilot Projects;Population;Population Heterogeneity;programs;Quality of Care;Quality of life;racial diversity;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;reduce symptoms;Refractory;Reporting;Resources;response;Safety;safety net;Self Efficacy;Self Management;Site;skills training;Spanish;Stomach;Structure;Symptom Burden;symptom management;symptomatic improvement;Symptoms;System;telehealth;Testing;therapy design;Tissues;Touch sensation;treatment as usual;Trust;Tube;tumor;Urinary tract;Vent;Visceral;Visit;wound care

PROJECT_TITLE: BOLSTER: Strengthening Patient and Caregiver Supports in Advanced Gynecologic and Gastrointestinal Cancers - a Multi-Site Randomized Controlled Trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Helicases are essential enzymes that unwind the strands of DNA and RNA. They are critical to maintaining the genomes of all organisms, and defective helicase function is implicated in various human disorders. The project will use advanced biophysical techniques to understand the mechanisms of helicases involved in repairing DNA damage, specifically investigating how helicase interactions with DNA and with accessory proteins regulate their functions.

PI_NAMEs: CHEMLA, YANN R. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Archaea;Biochemistry;biophysical techniques;Cells;Disease;DNA;DNA Damage;DNA Repair;DNA Structure;Enzymes;Eukaryota;Fluorescence Microscopy;Genome;genome integrity;Goals;helicase;Human;human disease;insight;laser tweezer;Life;Maintenance;Malignant Neoplasms;Measurement;member;Modeling;Molecular;Molecular Conformation;Molecular Machines;Nucleic Acids;optic tweezer;Organism;Pathology;Pathway interactions;Play;Process;Prokaryotic Cells;Proteins;recruit;Regulation;Research;Resolution;response;RNA;Role;single molecule;Structural Models;System;Virus;Work

PROJECT_TITLE: Mechanisms of DNA helicases and their regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Lynch syndrome (LS) affects over a million of people in the United States and is one of the leading causes of hereditary cancers (e.g., colorectal and endometrial cancer), which can be prevented or treated with active screening and early diagnosis. Cascade testing for at-risk relatives of patients with LS is cost-effective, but underutilized because there are many barriers to testing. Increasing pre-test genetic counseling in this population will have substantial public health impact by promoting awareness and identification of LS and subsequently help reduce cancer morbidity and mortality.

PI_NAMEs: YAN, HAOYANG  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adherence;Affect;anti-cancer research;Appointment;Area;arm;Attitude;Awareness;barrier to testing;Behavior;behavior change;behavior change wheel;Behavior Therapy;Behavioral;Behavioral Medicine;Blood;Cancer Control;cancer predisposition;cancer risk;career;career development;cascade genetic testing;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Colonoscopy;Colorectal Cancer;Conduct Clinical Trials;Consensus;cost effective;Counseling;Data;Decision Making;design;Development;Development Plans;Diagnosis;Distress;Drops;Early Diagnosis;efficacy testing;Endometrial Carcinoma;Ensure;Exercise;Family;feasibility trial;Focus Groups;Fright;Future;gene repair;General Population;Genetic Counseling;genetic counselor;Genetic Risk;genetic testing;Genomics;Grant;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;improved;Individual;Inherited;Insurance;Intervention;Interview;Knowledge;lifetime risk;Malignant Neoplasms;Medical;medical schools;men;Mentors;Methodology;Methods;Mismatch Repair;Morbidity - disease rate;mortality;motivated behavior;National Cancer Institute;Pamphlets;Participant;Pathogenicity;Patients;Persons;pilot trial;Population;Population Genetics;Positioning Attribute;prevent;Prevention;proband;Protocols documentation;prototype;Public Health;Publishing;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Relative Risks;Research;Research Activity;Research Personnel;Resources;Risk;Scientific Advances and Accomplishments;Scientist;screening;Social Sciences;Structure;supportive environment;Syndrome;Techniques;Testing;testing uptake;theories;therapy design;therapy development;Training;treatment arm;Treatment Efficacy;trial design;United States;Universities;uptake;usability;usual care arm;Variant;Woman;Writing

PROJECT_TITLE: Development and Initial Testing of a Behavioral Intervention to Increase Pre-Test Genetic Counseling Among Families at Risk of Lynch Syndrome


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity

PHR: Project Narrative: Mitochondrial metabolism plays an important but poorly understood role in the development of obesity related liver disease. Anaplerosis and cataplerosis are non-oxidative mitochondrial pathways that link biosynthetic and catabolic capacity to cellular energy metabolism, redox state and antioxidant function. This project investigates how anaplerosis impacts mitochondrial metabolism and impinges on liver disease.

PI_NAMEs: BURGESS, SHAWN C (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Amino Acids;Antioxidants;Catabolism;Citric Acid Cycle;Closure by clamp;conditional knockout;Consumption;cost;Cre driver;Development;Energy Metabolism;Equilibrium;Functional disorder;Gene Expression;Gluconeogenesis;Hepatocyte;Histology;Homeostasis;human disease;Immunohistochemistry;improved;in vitro Assay;in vivo;Individual;Inflammation;insight;Insulin;Insulin Resistance;Ischemia;knock-down;Knockout Mice;Link;Lipids;Liver;Liver diseases;liver function;liver injury;Liver Mitochondria;Lobular;Lobule;LoxP-flanked allele;Malates;malic enzyme;Mediating;Metabolic;Metabolic Control;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Mus;NADP;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nutrient;Obese Mice;Obesity;Obesity associated liver disease;obesity development;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;Phosphoenolpyruvate Carboxylase;Physiological;Play;Predisposition;Process;Production;Pyruvate;Pyruvate Carboxylase;Reaction;Recycling;Regulation;respiratory;Role;Signal Transduction;stable isotope;Testing;tool;Tracer;trafficking;urea cycle;Vision;western diet

PROJECT_TITLE: Factors Controlling Metabolic Flux in the Liver

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Trypanosomatid parasites cause devastating human diseases that affect millions of people worldwide. Drugs to treat these diseases are limited and parasite resistance to these drugs is on the rise. As our data on Trypanosoma brucei indicate, the cyclin-dependent kinase CRK9 forms a unique tripartite protein complex and has essential roles in the trypanosome-specific mode of gene expression and the completion of the cell cycle. Thus, analysis of the CRK9 enzyme architecture and of CRK9-controlled substrates, signaling pathways and mechanisms may unravel new chemotherapeutic intervention strategies.

PI_NAMEs: GUNZL, ARTHUR  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Ablation;Affect;African Trypanosomiasis;Alanine;analog;Animals;Architecture;Binding;Blood Circulation;Cell Cycle;Cell Cycle Completion;Cell Death;Cell Line;Cells;Chagas Disease;Chemicals;Classification;Clinical;Clinical Trials;Code;Complex;Cultured Cells;Cutaneous;Cyclin-Dependent Kinases;Cyclins;Cytokinesis;Data;Defect;Developing Countries;Development;deviant;Disease;Docking;Drug resistance;Drug Targeting;Enzyme Inhibition;Enzymes;Future;Gene Expression;Gene Order;Genes;Genetic Transcription;genome-wide;Germ;high throughput screening;Human;human disease;Immunoprecipitation;In Vitro;Individual;Infection;inhibitor;Intervention;Learning;Leishmania;Leishmaniasis;Libraries;Link;Messenger RNA;mimetics;Mitosis;mRNA Precursor;Multienzyme Complexes;Mus;Mutate;Mutation;neglected tropical diseases;Nuclear;overexpression;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Phase II/III Trial;Phosphorylation;Phosphotransferases;Polyadenylation;Pre-mRNA Polyadenylation Factor;Process;protein complex;Proteins;Reaction;Recombinants;Research;RNA;RNA Processing;RNA Splicing;Role;Signal Pathway;Site;small molecule inhibitor;Spliced Leader RNA;Spliced Leader Sequences;Spliceosome Assembly Pathway;Spliceosomes;Structure;System;Technology;Testing;Therapeutic;Therapeutic Intervention;tool;Trans-Splicing;transcriptome sequencing;Translations;Trypanocidal Agents;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Trypanosomiasis;Visceral;Wheat

PROJECT_TITLE: The essential role of cyclin-dependent kinase CRK9 in trypanosome pre-mRNA processing

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Basement membranes (BMs) are non-cellular protein layers that separate tissues forming cell-attachment sites and barriers between tissue compartments. The inner limiting membrane (ILM) is a special BM that prevents movement into the retina from the vitreous, as such it is a formidable barrier to cell- and gene-based therapies. The goal of this project is to manipulate the molecular structure of the ILM to promote integration of neural stem cells or viral transfection.

PI_NAMEs: BRUNKEN, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Animal Model;Astrocytes;Back;Basement membrane;Biological;Biological Assay;Biological Process;Biology;Blood Vessels;Bypass;Cell Therapy;Cell Transplantation;cell type;Cell-Matrix Junction;Cells;Cicatrix;clinically relevant;Collaborations;conditional knockout;Cre lox recombination system;Data;Dependovirus;depolymerization;Deposition;Development;Dyes;Effectiveness;Engineering;Engraftment;Excision;experimental study;Extravasation;Eye;Foundations;Future;gene therapy;Gene Transfer;Genes;Genetic;genetic approach;Goals;high risk;Immunologic Surveillance;In Vitro;in vivo;in vivo evaluation;infection rate;Inner Limiting Membrane;intravitreal injection;Knowledge;Label;Laboratories;Laminin;Mediating;Membrane;Methods;Microspheres;molecular rearrangement;Molecular Structure;mouse model;Movement;Mus;Nature;nerve stem cell;novel;Penetrance;Penetration;Physiological;polymerization;Polymers;prevent;Procedures;Proteins;Publishing;reconstitution;Reporter;response;Retina;Retinal Diseases;retinal progenitor cell;reverse genetics;Site;Stem cell transplant;stem cells;success;Techniques;Testing;theories;therapeutic gene;Therapeutic Intervention;Tissues;tool;Transfection;Vertebral column;Viral;Viral Vector;Virus;Virus Integration;Wild Type Mouse;Work

PROJECT_TITLE: Breaching the barrier with matrix biology.


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on genetic and epigenetic factors that underlie the etiology of Ph-like acute lymphoblastic leukemia where there exists a cancer health disparity within the Hispanic/Latino population regarding incidence, prevalence, and mortality. Further understanding of these factors lays the groundwork for predictive diagnostics and personalized preventative medicine. Thus, this proposal is relevant to the part of the NIH’s mission to foster discoveries pertaining to the causes, diagnosis, and prevention human diseases and improve human health.

PI_NAMEs: PANNUNZIO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: activation-induced cytidine deaminase;Acute Lymphocytic Leukemia;Address;Adolescent and Young Adult;Advocate;Affect;Automobile Driving;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;bcr-abl Fusion Proteins;Biological Assay;bisulfite sequencing;California;cancer health disparity;cancer risk;Catchment Area;Cells;Chromosomal translocation;Clinical;Collecting Cell;Communities;community living;Comparative Study;Comprehensive Cancer Center;CRISPR/Cas technology;Cytokine Receptors;Cytosine;Data;Deamination;Death Rate;Diagnosis;Diagnostic;digital;Disease;Disease remission;Disparity;DNA Double Strand Break;DNA Methylation;DNA Repair;Doxycycline;Early Diagnosis;Early Intervention;effective therapy;Enzyme Activation;Epigenetic Process;Ethnic Origin;Etiology;experimental study;Fostering;Gene Expression Profile;General Population;Genes;Genetic;Genome;genome-wide;Genomic Instability;Genomics;Goals;Health;health disparity;Heavy-Chain Immunoglobulins;high risk;Hispanic;hispanic community;Hispanic Populations;Human;human disease;IGH@ gene cluster;imprint;improved;improved outcome;Incidence;individualized prevention;innovation;Knowledge;Latino Population;lectures;lentiviral integration;Link;Maps;meetings;Methods;Methylation;methylation pattern;Mission;Modification;Molecular;mortality;Mutation;Not Hispanic or Latino;novel;novel diagnostics;Oncogenes;overexpression;Patients;personalized medicine;personalized predictions;Philadelphia Chromosome;Population;predictive marker;Predisposing Factor;Prevalence;Prevention;Prevention strategy;Preventive Medicine;Process;Public Health;Recurrent disease;Regulation;relapse risk;repaired;Research;Risk;Role;Sampling Studies;Site;stem;Survival Rate;Techniques;Testing;Time;treatment comparison;treatment response;United States National Institutes of Health;Whole Blood;Work

PROJECT_TITLE: Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative Hundreds of millions of dollars have been spent to identify the genes that cause human disease, with the hope that they will lead to better therapies. We expect that the proposed studies will reveal the function of Tcf7l2, the most important diabetes gene identified to date, a critical step towards reaping the benefits of human genetics.

PI_NAMEs: BIDDINGER, SUDHA B (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acute;amino acid metabolism;Amino Acids;Anatomy;bile acid metabolism;Bile Acids;Binding;Cell Nucleus;Central Vein;ChIP-seq;Chromatin;Data;Diabetes Mellitus;diabetic;dietary;Disease;Disease susceptibility;Dominant-Negative Mutation;Fasting;feeding;forging;Gene Expression;Gene Expression Profile;Genes;genetic association;Genetic study;Genetic Transcription;Genotype;Glucagon;Gluconeogenesis;Glucose;glucose metabolism;Glycolysis;Goals;Hepatic;Hepatocyte;hepatocyte injury;Heterogeneity;HIF1A gene;HNF4A gene;Homeostasis;human disease;Human Genetics;hyperglucagonemia;Hyperglycemia;In Vitro;insight;Insulin;Knock-out;Knockout Mice;lipid metabolism;Lipids;Liver;Lobule;Location;Metabolic;Metabolism;metabolomics;Modeling;Morphology;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Overnutrition;Pathogenesis;Pattern;personalized strategies;Physiological;Portal vein structure;Predisposition;prevent;Process;programs;response;Role;Signal Transduction;single nucleus RNA-sequencing;Stress;TCF7L2 gene;Technology;Testing;tool;Transcript;transcription factor;urea cycle;western diet

PROJECT_TITLE: The Role of Tcf7l2 in maintaining liver zonation and metabolic homeostasis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Because dysfunction of inflammatory and anti-inflammatory T cells has been associated with multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), control of T cell development and function is of major clinical interest. MicroRNAs (miRNAs) are a class of short non-coding RNAs critical in controlling gene expression. Most recently, we found a major role for microRNA-92a (miR-92a) in the regulation of pathogenic and regulatory T cells in EAE and MS. Findings from this proposal will advance our understanding of miR-92a in T cell function, and provide an incisive picture of molecular networks that could underlie new therapeutic avenues to treat disease, including miR-92a inhibitors.

PI_NAMEs: GOPAL, MURUGAIYAN  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;Attenuated;attenuation;autoreactive T cell;Biological Markers;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Central Nervous System;cerebral atrophy;Chronic;Clinical;clinically relevant;CNS autoimmunity;Data;Development;Disease;Disease remission;Equilibrium;Experimental Autoimmune Encephalomyelitis;FOXO1A gene;Frequencies;Functional disorder;Gene Expression;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Helper-Inducer T-Lymphocyte;Human;IL1R1 gene;Immune;immune function;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;inhibitor therapy;interest;interleukin-23;Mediating;MicroRNAs;Modeling;Molecular;Multiple Sclerosis;multiple sclerosis patient;Mus;neuroinflammation;Neurologic Symptoms;Neurons;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;pharmacologic;Phenotype;Production;programs;Regulation;Regulatory T-Lymphocyte;Relapse;response;Role;Severity of illness;T cell differentiation;T-Cell Development;T-Lymphocyte;Testing;Th1 Cells;therapeutic evaluation;therapeutically effective;Treatment Efficacy;Untranslated RNA

PROJECT_TITLE: The pathogenic role of miR-92a in the regulation of T helper cell responses in EAE and MS


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: LITTLE ROCK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Relevance: A non-invasive antepartum surveillance system using biomagnetic sensors could be a valuable tool for maternal and fetal well-being assessment.

PI_NAMEs: ESWARAN, HARI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Abdomen;acronyms;Algorithms;American Heart Association;antenatal;Arkansas;Atrial Flutter;Atrial Premature Complexes;Attenuated;Beds;Biomedical Engineering;Brain;Breathing;Cardiac;Cardiac conduction system;Clinic;clinical application;clinically relevant;Complex;cost;cryogenics;Data;data quality;design;Detection;Development;Diagnosis;Echocardiography;Electrocardiogram;Electrophysiology (science);fetal;Fetal health;Fetal Heart;Fetal Heart Rate;Fetal Monitoring;Fetal Movement;Fetus;flexibility;Geometry;Gestational Age;Goals;Heart Abnormalities;Heart Block;heart rate variability;Helium;Individual;Infrastructure;interest;Intervention;magnetic field;Magnetism;Maintenance;manufacture;manufacturing technology;Measures;Medical;Methods;Microfabrication;Modality;Mothers;Movement;multidisciplinary;myometrium;National Institute of Biomedical Imaging and Bioengineering;Nervous System Trauma;Noise;Optics;pediatric cardiologist;Performance;Personal Satisfaction;Pilot Projects;Positioning Attribute;postnatal;Pregnancy;Pregnant Women;prenatal;Production;Pump;reproductive;Research;Research Project Grants;response;Risk;Science;sensor;Shapes;Signal Transduction;superconducting quantum interference device;System;Tachycardia;Techniques;Technology;Testing;Third Pregnancy Trimester;time interval;tool;Translating;ultrasound;Universities;Uterus;Validation

PROJECT_TITLE: Development of low-cost optically pumped magnetometer system for fetal applications


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Palliative Care;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative The proposed study will determine in a seamless phase II/III design whether older and/or medically infirm patients with hematological malignancies will see an improvement in their quality of life following allogeneic hematopoietic cell transplantation when treated with one of three novel peri-transplant interventions: supportive and palliative care, clinical management targeting specific comorbidities, and both interventions combined. Overall survival, non-relapse mortality, other patient-reported outcomes, and use of resources will also be compared between the intervention arms.

PI_NAMEs: SORROR, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Affect;Age Years;Aging;Allogenic;arm;Blood;Bone Marrow Transplantation;cancer therapy;Cardiac rehabilitation;Caregivers;Clinical;clinical care;Clinical Management;Collaborations;Communication;comorbidity;comorbidity Index;comparison intervention;curative treatments;Decision Making;design;dietary;Discipline;Donor person;donor stem cell;Education;effectiveness study;Enrollment;Ensure;Evaluation;experience;experimental arm;Feasibility Studies;follow-up;frailty;Fright;Futility;Future;Goals;health related quality of life;Healthcare;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Homologous Transplantation;human old age (65+);Hygiene;Impairment;improved;improved outcome;indexing;Intervention;Longitudinal, observational study;Lymphatic System;Malignant Neoplasms;Managed Care;Measures;Medical;Medication Management;member;Methods;Morbidity - disease rate;mortality;mortality risk;multimodality;novel;Outcome;Palliative Care;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;phase 2 study;phase 3 study;Phase II/III Clinical Trial;Physical Exercise;Physicians;Pilot Projects;primary endpoint;Procedures;prognostic;programs;prospective;pulmonary rehabilitation;Quality of life;Randomized;randomized, clinical trials;rare cancer;Research;Resources;Risk Assessment;smoking cessation;standard of care;stress reduction;Supportive care;Symptoms;Testing;Training;transplant centers;Transplant Recipients;Transplantation;treatment arm;walking speed

PROJECT_TITLE: Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Parasitic worms, allergens, and some protists all trigger a “type 2” immune response, but we do not yet fully understand the underlying mechanisms of immune sensing and regulation. More than 1 billion individuals are currently infected with worms, and the incidence of allergies is rising worldwide. By studying the role of epithelial tuft cells in type 2 immunity, we hope to discover novel targets for therapeutic intervention in helminth infection and allergy.

PI_NAMEs: VON MOLTKE, JAKOB H. (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Agonist;Allergens;Attenuated;Binding Sites;Biochemical;Biological Assay;Cations;Cell Differentiation process;Cell Physiology;Cells;Cellular Assay;Chemicals;Chromosome 9;Chromosome Mapping;Cre driver;Cues;cytokine;Developmental Process;dysbiosis;Economics;Enteral;enteric virus infection;Eosinophilia;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;extracellular;Food Hypersensitivity;Fractionation;Frequencies;Genes;Genetic Transcription;genomic locus;helminth infection;Helminths;Hematopoiesis;Human;Hyperplasia;Hypersensitivity;Ileitis;Immune;Immune response;Immunity;Immunologics;in vitro Assay;Inbred BALB C Mice;Incidence;Individual;Inflammation;inhibitor;insight;Interleukin-13;interleukin-13 receptor;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;intestinal injury;Lamina Propria;Leukotrienes;Ligands;Link;Livestock;LoxP-flanked allele;Lymphoid Cell;Mediating;microbial;Morbidity - disease rate;Mus;new therapeutic target;novel;nutrient absorption;Organoids;Osmolar Concentration;Output;Pathologic;Pathology;Pathway interactions;Physiological;Positioning Attribute;Predisposition;Proliferating;promoter;Proto-Oncogene Protein c-kit;receptor;Regulation;Role;Sampling;Sensory;Signal Pathway;Signal Transduction;Small Intestines;STAT6 gene;stem;stem cells;Succinates;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;transcription factor;transcriptome sequencing;Tritrichomonas;TRPM5 gene;Virus

PROJECT_TITLE: Regulation of the tuft-ILC2 circuit in the small intestine

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

PHR: Project Narrative Disturbances in the recycling of synaptic vesicles cause severe defects in brain functions. The studies proposed here will provide critical information regarding the molecular mechanisms governing synaptic vesicle endocytosis. The proposed research will significantly advance our understanding of neurotransmission, and will guide therapeutic intervention for neurodegenerative diseases.

PI_NAMEs: BAI, JIHONG  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: age related;Area;Biochemical;Biology;Brain;Bypass;Chimera organism;Communication;Coupled;Data;Defect;Electron Microscopy;Electrophysiology (science);Endocytosis;Event;exhaust;Functional disorder;gene function;Genetic;Genetic Screening;Goals;Health;Human;Image;In Vitro;in vivo;insight;Knowledge;Laboratories;Lead;Link;Lipids;Maintenance;Membrane;Mental disorders;Molecular;Mutation;Mutation Analysis;N-terminal;Natural regeneration;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurons;neurotransmission;Neurotransmitters;Parkinsonian Disorders;Pathway interactions;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Play;prevent;Process;protein protein interaction;Proteins;Recycling;Research;Role;Route;sensor;Signal Transduction;Synapses;Synaptic Transmission;Synaptic Vesicles;SYNJ1 gene;Testing;Therapeutic Intervention;Work

PROJECT_TITLE: Membrane Curvature Sensing Mechanisms for Synaptic Vesicle Endocytosis

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

PHR: PROJECT NARRATIVE Legionella pneumophila (Lp) is the agent of a severe form of pneumonia known as Legionnaires' disease and an intracellular parasite of macrophages and epithelia when it is introduced in the lungs. We have gained first- time evidence that Lp secretes multiple mucinase activities, with one of them (ChiA) being a multifunctional chitinase that degrades both gel-forming mucins from the lungs and a component of the human complement system. Mucinases are an emerging part of understanding Lp and pneumonia pathogenesis and potential targets for addressing disease, and therefore, the proposed studies are aimed at determining how Lp mucinases promote infection and in different ways.

PI_NAMEs: CIANCIOTTO, NICHOLAS P (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active Sites;Address;aerosolized;Alveolar;Bacteria;Binding;Biological;Biological Assay;C-terminal;Carbohydrates;CD46 Antigen;Cells;Chitin;Chitinase;Complement;complement system;Data;Development;Devices;Disease;Documentation;Epithelial Cells;Epithelium;Event;exoenzyme;Exopeptidase;extracellular;Fostering;Gel;Glycoproteins;Gram-Negative Bacteria;Growth;Human;Impairment;improved;In Vitro;in vivo;Incidence;Infection;Inhalation;insight;Intervention;intracellular parasitism;Legionella pneumophila;Legionnaires' Disease;Link;Lung;Lung infections;lung pathogen;Macrophage;Mammals;Mediating;Modeling;monolayer;MUC5AC gene;mucinase;Mucins;Mucous body substance;Mus;mutant;N-terminal;Parasites;pathogen;Pathogenesis;Penetration;Peptide Hydrolases;Pneumonia;programs;Proteins;Reporting;Research Project Grants;Resistance;Role;Serum;Structure;Testing;Time;Type II Secretion System Pathway;United States National Institutes of Health;Water;Work

PROJECT_TITLE: Mucinases as Emerging Players in Legionella pneumophila Pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative The unifying postulate of this competitive renewal P01 proposal is that comparative studies of KSHV, EBV, and MHV68 will continue to accelerate the discovery of pathways regulated by non-coding RNAs (ncRNAs). Our findings over the last 4 years indicate that both short and long ncRNAs contribute to γ-herpesvirus latency and tumorigenesis.

PI_NAMEs: RENNE, ROLF F (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS related cancer;Algorithmic Analysis;Algorithms;angiogenesis;biobank;Bioinformatics;Biology;Biometry;Burkitt Lymphoma;cancer specimen resource;Cell Line;Cells;chronic infection;circular RNA;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;comparative;Comparative Study;Consultations;crosslink;Data;data analysis pipeline;Development;DNA;Endothelium;Epstein-Barr virus encoded RNA 1;Epstein-Barr Virus-Related Malignant Neoplasm;Florida;Funding;gammaherpesvirus;Gene Expression;Generations;glucose metabolism;Goals;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Hybrids;Immune Evasion;In Vitro;in vitro Model;in vivo;innovation;Laboratories;Lesion;Link;Lymphoid Cell;Lymphomagenesis;Malignant Neoplasms;malignant stomach neoplasm;maxillofacial;Microprocessor;MicroRNAs;migration;Molecular;mouse model;Mus;novel;novel therapeutic intervention;Oncogenic;Oral;Palate Kaposi's Sarcoma;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;programs;Proliferating;Protocols documentation;Publications;Publishing;Quality Control;recombinant virus;recruit;Reporting;Reproducibility;Research;Resolution;RNA;RNA Splicing;Role;Sampling;Seminal;Services;South Africa;System;Techniques;Therapeutic Intervention;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumorigenesis;Universities;Untranslated RNA;Viral;Viral Proteins;Virus;Virus Latency;Xenograft procedure

PROJECT_TITLE: Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: NARRATIVE Kaposi’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s Sarcoma and B cell lymphomas. KSHV expresses 12 miRNA genes and a number of viral long noncoding RNAs, including anti-sense and circular RNAs. Using ribonomcs techniques we demonstrated that KSHV infection leads to de-regulation of cellular lncRNAs in a miRNA-dependent and -independent fashion. The main focus of this project is to increase our understanding of how viral short and long noncoding RNAs contribute to viral disease, and specifically to tumor formation.

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;AIDS related cancer;angiogenesis;B-Cell Lymphomas;B-Lymphocytes;Binding Proteins;bioinformatics pipeline;Biological Assay;Biology;Cells;circular RNA;Code;Collaborations;comparative;Comparative Study;Complex;CRISPR interference;crosslink;Data;Data Analyses;Data Set;density;Development;Endothelial Cells;Experimental Designs;Funding;gammaherpesvirus;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;Global Change;glucose metabolism;Goals;Growth;Herpesviridae;Herpesviridae Infections;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hybrids;In Vitro;in vivo;in vivo Model;innovation;Investigation;Kaposi Sarcoma;Knock-out;Laboratories;Link;Lymphoproliferative Disorders;lytic replication;MALAT1 gene;Malignant Neoplasms;Messenger RNA;Methods;MicroRNAs;migration;miRNA expression profiling;Modeling;Multiomic Data;multiple omics;Mus;mutant;novel;novel therapeutic intervention;Pathogenicity;Pathway interactions;Phenotype;primary effusion lymphoma;programs;Proliferating;Proteins;Protocols documentation;Publications;Publishing;Reporting;RNA;RNA Splicing;Role;Sampling;Signal Pathway;South Africa;Specimen;Structure;success;System;Techniques;tissue culture;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Treatment Protocols;tumor;Tumor Suppressor Proteins;tumorigenesis;Universities;Untranslated RNA;Validation;Viral;viral interferon regulatory factor;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;virus genetics;Work;Xenograft procedure

PROJECT_TITLE: "Project 1" KSHV short and long noncoding RNAs and alteration of host IncRNA expression


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Melanin is a very important pigment in the biosphere and is involved in numerous biological processes from protection against sunlight to energy harvest. Melanin is made by many pathogenic organisms, including several pathogenic fungi. It contributes to fungal virulence by undermining host defense mechanisms and increasing fungal resistance to certain antifungal drugs. This proposal will take a multidisciplinary approach to the problem of melanogenesis in the fungal pathogen Cryptococcus neoformans by seeking to understand how melanin is made, with the goal of discovering new science that can lead us to novel therapies that target melanization pathways.

PI_NAMEs: CASADEVALL, ARTURO  (contact);NOSANCHUK, JOSHUA D;STARK, RUTH E.

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: absorption;acquired drug resistance;Acquired Immunodeficiency Syndrome;Affect;Anabolism;Animals;anti-fungal agents;Basic Science;Biochemical;Biological Process;Biology;Cell model;Cell Wall;Cells;Cellular biology;Cessation of life;Chemicals;Chronic;Complex;crosslink;Cryptococcus;Cryptococcus neoformans;Crystallization;Cytoprotection;cytotoxic;Deposition;drug development;Effector Cell;Electromagnetic Energy;Electrons;Energy harvesting;Equus caballus;Family;Fractionation;Free Radicals;fungus;glyphosate;Goals;Host Defense Mechanism;host-microbe interactions;Human;human pathogen;Immune;Immunity;immunosuppressed;Impairment;Individual;Infection;inhibitor;insight;interdisciplinary approach;Investigation;Label;Laccase;Lead;Libraries;Light;Lipids;Location;Macrophage;Mammals;Mediating;melanin inhibitor;Melanins;Melanogenesis;Melanosomes;Metabolic;Modeling;Molecular;Mus;Mycoses;Nature;new therapeutic target;NMR Spectroscopy;novel;Organ;Organism;Paper;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Pigments;Plants;Polyenes;polymerization;Polymers;Polysaccharides;Population;Predisposition;prevent;Process;programs;Property;Radiation;Reaction;Research;Resistance;Role;Science;small molecule;small molecule inhibitor;solid state nuclear magnetic resonance;Structure;Sunlight;System;targeted agent;Techniques;Testing;Therapeutic Uses;Time;Tissues;toxic metal;Ultraviolet Rays;Vesicle;vesicle transport;Virulence;Work

PROJECT_TITLE: The biology of Cryptococcus neoformans melanization


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Project narrative The Epstein Barr virus (EBV) is a primary causative agent in HIV-associated lymphomas. Based on preliminary studies in tissue culture and clinical models, we hypothesize that two large EBV miRNA clusters are critical players in eliciting the tumor phenotype through altering the immune cell microenvironment via their canonical functions and cell growth and/or protection against cell death through a previously unknown non-canonical mechanism.

PI_NAMEs: FLEMINGTON, ERIK K (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Affinity;AIDS related cancer;AIDS-Related Lymphoma;Animal Model;Autoimmune Diseases;Binding;Biogenesis;Bioinformatics;Biology;biophysical analysis;Burkitt Lymphoma;Cancer Patient;cancer type;Cell Death;cell growth;Cell Survival;Cells;Clinical;co-infection;Collaborations;Cytoprotection;Data;Data Set;density;Down-Regulation;driver mutation;Epitopes;Epstein Barr Virus associated tumor;Epstein-Barr virus encoded RNA 1;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Etiology;expression vector;gammaherpesvirus;Gene Expression;Genes;Genetic Materials;Herpesviridae;HIV;Hodgkin Disease;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Hybrids;Immune;immune cell infiltrate;Immune response;Immune Targeting;in vivo;Infection;Innate Immune Response;Interferon Type II;Introns;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Messenger RNA;Microprocessor;MicroRNAs;Modeling;mouse model;Mus;Mutation;Nasopharynx Carcinoma;neoplastic cell;Non-Hodgkin's Lymphoma;Oncogenes;Oncogenic;Pathway interactions;Patients;Phenotype;Production;Property;reconstitution;Regulatory Pathway;Resources;Risk;RNA;Role;Sampling;SCID Mice;Signal Pathway;Signal Transduction;Specimen;T-Cell Receptor;Testing;Time;tissue culture;Transcript;transcriptome;transcriptome sequencing;Transfection;tumor;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA;Viral;Viral Genes;viral RNA;Virus Diseases;virus genetics;Work;Xenograft procedure

PROJECT_TITLE: "Project 2" Microprocessor overload in gamma-herpesviral oncogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Rare Diseases;Skin Cancer

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Kaposi Sarcoma (KS) is a cancer caused by Kaposi sarcoma-associated herpesvirus (KSHV) and is very common in individuals with HIV/AIDS. Weakening of the immune system is thought to play a role in allowing KSHV infection to occur and KS to develop. We propose to use common marmoset monkeys to demonstrate that the removal of immune cells allows KSHV infection and KS development.

PI_NAMEs: MUTSVUNGUMA, LORRAINE ZVICHAPERA (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: AIDS with Kaposi's sarcoma;Animal Experiments;Animal Model;Animals;Antibodies;Antibody Response;B-Lymphocytes;Biochemical;Blood Pressure;Callithrix;Callithrix jacchus jacchus;Cancer Etiology;Case Study;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;cell mediated immune response;Cells;Chemicals;Collaborations;Complex;cytotoxic CD8 T cells;Defect;Development;Dose;Drops;Drug Kinetics;Etiology;Excision;Exhibits;Frequencies;frontier;Herpesviridae Infections;high risk;HIV;HIV Seronegativity;HIV/AIDS;Human;Human Herpesvirus 8;human pathogen;Immune;Immune response;Immune system;Immunocompetent;Immunocompromised Host;immunodeficiency;immunosuppressed;Immunosuppression;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Intravenous;Japan;Kaposi Sarcoma;Laboratories;Lesion;Light;Malignant Neoplasms;Mediating;Methods;Modeling;Monkeys;Monoclonal Antibodies;murine monoclonal antibody;Mus;Newly Diagnosed;nonhuman primate;oral infection;Pathogenesis;Peripheral Blood Mononuclear Cell;permissiveness;Persons;Play;Population;Predisposition;Primates;Property;Reagent;reconstitution;Research;Resolution;Resources;respiratory;response;Role;Serum;side effect;skin lesion;Splenocyte;T cell reconstitution;T cell response;T-Cell Depletion;T-Lymphocyte;Tacrolimus;tool;Toxic effect;Urea;Viral Load result;Virus;Virus Diseases;Wisconsin

PROJECT_TITLE: Use of a non-human primate model to define the role of T cell immune responses in persistent Kaposi sarcoma-associated herpesvirus infection and Kaposi sarcoma pathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


PHR: Project Narrative The transforming human gammaherpesviruses EBV and KSHV establish stable latent infections in B cells, providing a lifelong reservoir of virus that can contribute to the development of malignant disease. Thus, defining the mechanisms that govern long-term latency and tumorigenesis is critical for designing rational strategies to prevent disease. In work here, we will use a mouse model of gammaherpesvirus infection and tumorigenesis to defined the mechanisms by which viral noncoding RNAs shape critical B cell signaling pathways to promote virus dissemination, latency and tumorigenesis.

PI_NAMEs: TIBBETTS, SCOTT A. (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Animal Model;B-Cell Lymphomas;B-Lymphocytes;Biological;Biological Models;Biology;Cell Physiology;Chronic;chronic infection;Code;Collaborations;Comparative Study;Data;defined contribution;Development;digital;Disease;Epstein-Barr virus encoded RNA 1;Epstein-Barr virus encoded RNA 2;Event;experimental study;Foundations;gammaherpesvirus;Genes;Genetic Transcription;Goals;Hematogenous;Herpesviridae;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hyperplasia;Immunocompromised Host;Immunologics;in vivo;in vivo evaluation;infected B cell;Infection;innovation;latent infection;Lesion;Link;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;MicroRNAs;Molecular;mouse model;Mus;mutant;Nature;novel;Outcome;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Play;prevent;programs;Proteins;rational design;recombinant virus;Regulation;Reporting;Repression;RNA;Role;Shapes;Signal Pathway;Site;small hairpin RNA;Small RNA;Surface;System;Technology;Testing;Transcript;Transfer RNA;Translations;tumor;tumor progression;tumorigenesis;Untranslated RNA;Viral;Viral Physiology;Viral reservoir;Virus;Work

PROJECT_TITLE: "Project 3" Defining the in vivo function of ncRNAs during MHV68 latency and lymphomagenesis