ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The threat of climate change and urgency to transition away from fossil fuels are broadly recognized. The proposed Health-First Climate Action Research Center will establish the nation’s first Climate Change and Health Research Center dedicated to investigating the potential health benefits of various policy and practice initiatives related to the transformation of energy and transportation systems made necessary by the threat of climate change. Grounded in community-engagement and innovative yet rigorous science, this Center will seek practical, actionable, and evidence-based solutions to optimize health and equity benefits as the nation’s energy transformation advances.

PI_NAMEs: PATZ, JONATHAN ALAN (contact)

PROJECT_TERMS: Acceleration;Action Research;Address;Air;Air Pollution;Artificial Intelligence;Asthma;Automobile Driving;Carbon;Child;Chronic Obstructive Pulmonary Disease;Cities;citizen science;Climate;climate change;climate crisis;climate data;climate impact;climate policy;climate-related health;Communication;Communities;community advisory board;community engaged research;community engagement;community involvement;community organizations;community partners;Complex;Computer software;computerized;cost;criteria air pollutant;crowdsourcing;Data;Data Collection;Data Commons;data repository;data reuse;Data Science;Data Science Core;data sharing;data tools;Decision Making;Dedications;design;Development;digital;Electricity;Environment;Epidemiology;Equity;Ethics;evidence base;Fossil Fuels;Fostering;Foundations;Future;Global Warming;Goals;Government;Grant;greenhouse gases;Health;Health Benefit;health equity;Health Priorities;Human;innovation;innovative technologies;insight;Institution;Intervention;Investments;Justice;Knowledge;Learning;Link;Machine Learning;Maps;Metadata;Modeling;Monitor;Morphologic artifacts;mortality;Natural Language Processing;Neighborhoods;Online Systems;Pathway interactions;Planets;Policies;Policy Developments;Policy Maker;Preventive;Process;Productivity;programs;prototype;Public Opinion;Research;research and development;Research Project Grants;resilience;Resolution;Risk;Schools;Science;Speed;stem;System;Technology;tool;Translational Research;Transportation;Universities;Voice;Wisconsin;Work

PROJECT_TITLE: A Community-Driven, Health-First Approach to Climate Action and the Energy Transition


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: PROJECT NARRATIVE Project Narra�ve is located in the Overall Component.

PROJECT_TERMS: Action Research;Advisory Committees;Air Pollutants;Air Pollution;Area;authority;Award;Carbon;Case Study;Child;Climate;climate change;climate impact;climate policy;climate science;climate-related health;Clinical;Collaborations;Communication;Communities;community advisory board;community center;community engagement;community partners;Consultations;Costs and Benefits;dashboard;Data;Data Commons;Data Science;Data Science Core;Decision Making;design;Development;digital platform;Discipline;Dissemination and Implementation;Effectiveness;Ensure;Environmental Epidemiology;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Goals;Grant;Group Interviews;Health;health equity;Health equity research;health goals;Health Sciences;Human Resources;Hybrids;improved;Individual;innovation;Institution;Leadership;Learning;Life;Manuscripts;medical schools;meetings;member;Mission;Modeling;multidisciplinary;operation;Outcome;Pathway interactions;Pilot Projects;Policies;Policy Analysis;Positioning Attribute;Process;programs;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Science;Scientist;Structure;success;Surveys;Transportation;United States National Institutes of Health;Visualization;Voting Right;web site;Wisconsin;Work;Writing

PROJECT_TITLE: Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Accounting;Action Research;Address;Adoption;Air;Air Pollutants;Air Pollution;Area;Articulation;Asthma;Atlases;burden of illness;Carbon;Chronic Obstructive Pulmonary Disease;Cities;Climate;climate change;climate impact;climate policy;climate-related health;Communities;community advisory board;community based participatory approach;community center;community empowerment;community engagement;community partners;Complement;Complex;Coupled;crowdsourcing;Data Science Core;data visualization;Decision Making;design;Development;digital data;Dimensions;Disparity;Electricity;energy balance;environmental justice;Equity;Evaluation;evidence base;Exposure to;fine particles;Frequencies;Goals;greenhouse gases;Group Interviews;Health;Health Benefit;health equity;Health equity research;health inequalities;Health Status;Human;improved;Individual;Industry;interest;Intervention;Interview;Knowledge;Life Cycle Stages;Link;long-standing disparities;Long-Term Effects;Measures;member;Methodology;Modeling;mortality;Neighborhoods;Nitrogen Oxides;Output;Ozone;Policies;Policy Making;pollutant;Pollution;Population;Power Plants;Process;Protocols documentation;Publishing;Research;Research Project Grants;Resolution;response;Risk;Science;social;social engagement;Source;Speed;Sulfur Dioxide;Techniques;Technology;tool;translational impact;Transportation;United States National Institutes of Health;Voice;volatile organic compound;Wisconsin

PROJECT_TITLE: Project


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;Action Research;Affect;Air Pollution;Award;Carbon;Climate;climate change;climate policy;climate-related health;Communication;Communities;community academic partnership;community advisory board;community center;community engaged approach;community engagement;community engagement process;Community Health;community organizations;community science;cost;Critiques;crowdsourcing;Data;Data Collection;Data Science;Data Science Core;design;Development;digital;Environmental Health;Environmental Impact;environmental justice;Evaluation;Event;Feedback;Foundations;Funding;Goals;Grant;Health;health equity;Health equity research;health inequalities;innovation;innovative technologies;Interdisciplinary Study;Investments;Knowledge;Learning;Local Government;meetings;Monitor;Outcome;Pilot Projects;Policies;Pollution;Process;Research;Research Personnel;Research Project Grants;response;sensor;State Government;Structure;Surveys;synergism;Technology;Vision;Visualization;web site;Wisconsin;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Social Determinants of Health

PROJECT_TERMS: Academia;Action Research;Address;Adoption;Adverse effects;Air;analytical tool;Artificial Intelligence;Back;Big Data Methods;Bioinformatics;Cell Nucleus;Climate;climate change;climate data;climate impact;climate policy;climate zone;climate-related health;cloud based;Collaborations;Communication;Communities;community collaboration;community engagement;Community Integration;community involvement;Computer software;cost effectiveness;crowdsourcing;Data;Data Analyses;Data Analytics;Data Collection;Data Commons;data ecosystem;data infrastructure;data integration;data management;data platform;data reuse;Data Science;Data Science Core;Data Set;data sharing;Decision Making;development policy;digital computing;digital divide;digital technology;digital tool;Discipline;Disparate;diverse data;Ensure;Equity;Ethics;evidence base;experience;FAIR principles;Feedback;Fostering;Foundations;Future;Government;Guidelines;Health;health data;Health Policy;Hearing;holistic approach;Human;improved;informatics tool;Information Dissemination;Infrastructure;innovation;insight;Intake;interdisciplinary collaboration;Machine Learning;Maps;member;Metadata;Methods;Modeling;Monitor;multidisciplinary;multiple data sources;next generation;Outcome;Participant;Pilot Projects;Policies;Policy Maker;Policy Research;Privacy;Process;prototype;Public Health;Quality Control;Reporting;repository;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;resilience;Resources;satisfaction;Science;Secure;Security;Source;Standardization;System;Techniques;Testing;tool;Translating;United States National Institutes of Health;Vision;Visualization software;Voice;Wisconsin;Work

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: NS

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: RIVERSIDE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Narrative: Epilepsies contribute to over a quarter of the disability burden of neurological disorders with cognitive deficits impacting quality of life. Studies proposed here will identify fundamental mechanisms of memory processing in the hippocampal dentate gyrus, a circuit heavily impacted in temporal lobe epilepsies, and how they are altered by adaptive and maladaptive circuit changes in epilepsy. The studies will address key knowledge gaps relevant to the 2021 AES/NINDS Epilepsy Research Benchmarks priority area of understanding mechanisms of neuropsychiatric comorbidities in epilepsy and have broader relevance to mechanisms of memory decline in ageing and neurodegenerative disorders like Alzheimer’s Disease.

PI_NAMEs: SANTHAKUMAR, VIJAYALAKSHMI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Area;Axon;Behavior;Behavioral;behavioral study;Benchmarking;Biological Assay;Cannabinoids;Cells;Cholecystokinin;CNR1 gene;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cognitive process;comorbidity;Compensation;Dendrites;dentate gyrus;Detection;disability burden;Discrimination;discrimination task;Distal;Dorsal;entorhinal cortex;Epilepsy;Episodic memory;Event;Frequencies;functional plasticity;Generations;genetic approach;granule cell;hippocampal sclerosis;Hippocampus;Impairment;in vivo;induced pluripotent stem cell;inhibitory neuron;Interneurons;Knowledge;Lateral;Location;long term memory;Medial;Mediating;Memory;memory consolidation;Memory Disorders;Memory Loss;memory process;memory recall;memory retrieval;Modality;Molecular;Mus;Myoepithelial cell;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropsychiatry;novel;optogenetics;Output;Parvalbumins;Pathway interactions;Patients;Pattern;Perforant Pathway;Physiologic pulse;Pilocarpine;Process;Quality of life;recruit;Regulation;Research;response;Role;segregation;Seizures;Short-Term Memory;Site;Slice;Somatostatin;Space Perception;Status Epilepticus;Stimulus;Stream;Structure;Synapses;Temporal Lobe Epilepsy;Testing;Therapeutic;Transgenic Mice;transmission process;With laterality

PROJECT_TITLE: Inhibitory Network Plasticity in Neurological Disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Brain Disorders;Multiple Sclerosis;Nanotechnology;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Multiple sclerosis is a debilitating disease caused by autoreactive immune responses that lead to demyelination and results in loss of neurologic function. Currently available medications address the inflammatory component of the disease but do not prevent progressive degeneration of neurons. This study will develop a new multi- component, multi-functional, nanotherapeutic with improved targeting efficiency and therapeutic function for MS.

PI_NAMEs: WANG, AIJUN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Address;Adult;Affinity;Amyloid beta-Protein Precursor;angiogenesis;antagonist;Area;Astrocytes;Autoimmune Diseases;autoreactivity;Axon;axon injury;axonal degeneration;axonopathy;B-Lymphocytes;Biochemical;Biodistribution;Biological Assay;Biomedical Engineering;Blinded;Bromodeoxyuridine;C57BL/6 Mouse;Cell Differentiation process;Cell Proliferation;Cell Therapy;Cells;Central Nervous System Diseases;Child;Chronic;Clinical;clinical application;combinatorial;cytokine;Demyelinating Diseases;Demyelinations;design;Diagnosis;Diameter;Disease;Drug or chemical Tissue Distribution;Engineering;experience;Experimental Autoimmune Encephalomyelitis;extracellular vesicles;Flare;Flow Cytometry;Fluorescence;Future;Goals;Histologic;Histology;Homing;Image;imaging system;Immune;Immune response;Immunologics;immunoregulation;improved;In Vitro;Incidence;Inflammation;Inflammatory;Injury;insight;Integrin alpha4beta1;Integrins;Investigation;Label;Leukocytes;Ligands;Lumbar spinal cord structure;Lymphocyte;Macrophage;Measures;Mediating;Mesenchymal;Methods;Microglia;Modeling;Modification;Molecular Analysis;motor function improvement;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;Myelin;Myelin Basic Proteins;Myelin Sheath;myelination;nanotherapeutic;Nerve Degeneration;Nervous System Physiology;Neurologic Deficit;Neurological disability;Neurons;neuroprotection;novel;novel therapeutics;oligodendrocyte progenitor;Oligodendroglia;optical imaging;Organ;Outcome;Pathogenicity;Patients;Peptides;Pharmaceutical Preparations;Placenta;precursor cell;Pregnancy;Recovery of Function;regeneration function;regeneration potential;regenerative;regenerative therapy;Relapse;remyelination;Risk;screening;secondary infection;Site;Specificity;Stains;stem;stem cells;Stromal Cells;Surface;Symptoms;T-Cell Proliferation;T-Lymphocyte;targeted treatment;technology platform;Therapeutic;Therapeutic Agents;Thick;Tissues;Tolonium chloride;Training;Treatment Efficacy;Tropism;uptake;young adult

PROJECT_TITLE: Engineering an extracellular vesicle-based targeted regenerative nanotherapeutic for multiple sclerosis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FAYETTEVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative The primary goal of the present proposal is to use a rigorous multi-method approach to determine how and when adverse provider conditions (e.g., burnout, illness, concerns about own health, and inflammation) lead to lower quality of care, especially for patients from racial and ethnic minorit ized groups. The proposed research points to potential and novel sources of bias that have time-dependent opportunities for intervention, distinct from (but complementary to) traditional approa ches to implicit bias training. Moreover, the proposed research will provide additional, novel evidence supporting the importance of addressing system-level issues of inadequate staffing and provider burnout.

PI_NAMEs: MAKHANOVA, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Abdominal Pain;Accident and Emergency department;Acute;Address;Administrator;Admission activity;Affect;Ally;Asian;Black race;Blood;burnout;Caring;Clinical Management;Cognitive;Computerized Medical Record;cytokine;Data;Decision Making;design;Development;Disparity;disparity reduction;effective intervention;Emergency department visit;Emergency Medicine;Equity;ethnic minority population;Ethnic Origin;experience;explicit bias;Goals;Health;health care disparity;health disparity;health inequalities;Health Personnel;Health Policy;Healthcare;Healthcare Systems;Hospitalists;Hour;Image;implicit bias;improved;indexing;Inflammation;Inflammatory;influenza virus vaccine;innovation;insight;Interleukin-1 beta;Interleukin-6;Internal Medicine;Intervention;Knowledge;Laboratories;Latinx;Lead;Length of Stay;Link;longitudinal design;marginalization;Measures;Medical;Methods;Minority Groups;Motivation;National Institute on Minority Health and Health Disparities;novel;Nurse Practitioners;Pain;Pain management;pain perception;Participant;Patient Care;Patient-Focused Outcomes;Patients;Perception;Physician Assistants;Physicians;Placebos;Policies;Prejudice;programs;prospective;Provider;provider factors;Psychology;Psychoneuroimmunology;Quality of Care;Race;racial minority population;racial population;Randomized;recruit;Reporting;Research;response;Role;Sick Leave;social;Social Distance;social norm;Source;Standardization;standardize measure;Stress;Symptoms;System;Testing;theories;therapy design;Time;Training;Vaccines;Workplace

PROJECT_TITLE: The Impacts of Adverse Provider Conditions on Provider Bias and Health Disparities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Nutrition;Obesity

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The intestinal epithelium is central to obesity-related interorgan communication networks, as it can sense die- tary and internal metabolic inputs, and communicate to affect the activity of distal tissues including the adipose tissue, or fat. Here, we will use mice in which all proteins that are secreted from the intestine are labeled, in order to define both how obesity influences secretion of proteins from the intestine, and how the target subcu- taneous and visceral white adipose tissues are impacted by altered interorgan signaling mediated by intestine- secreted proteins. In the future, the identified secreted proteins could become next-generation therapeutics to improve lipid metabolism and energy expenditure in obesity to improve medical practice and health.

PI_NAMEs: DROUJININE, ILIA  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adipocytes;adipose derived stem cell;Adipose tissue;Affect;Affinity;Biogenesis;Biology;Biotin;Biotinylation;Body Weight;Brown Fat;Cells;Cholecystokinin;Communication;Destinations;Diet;diet-induced obesity;dietary;Disease;Distal;Eating;Endoplasmic Reticulum;Energy Metabolism;Engineering;Etiology;Fasting;Fatty acid glycerol esters;feeding;Fibroblast Growth Factor;Fibrosis;Future;gain of function;GCG gene;glucagon-like peptide 1;Glucose;glucose metabolism;Goals;Health;High Fat Diet;Homeostasis;Hormones;Human Genetics;Hyperphagia;Hypertrophy;improved;In Vitro;in vivo;Inflammation;insulin sensitivity;intestinal epithelium;Intestinal Secretions;Intestines;knock-down;Knock-out;Label;Leptin;Ligase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;Mass Spectrum Analysis;Mediating;Medical;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;Mitochondria;model development;Mus;Mutation;Nonesterified Fatty Acids;novel;novel therapeutics;Obesity;obesity development;Organ;Pancreas;parallelization;Phenotype;Play;plexin;Population;Production;Protein Secretion;protein transport;Proteins;Proteome;Proteomics;Reading;receptor;Regulation;Resources;response;Role;screening;Serum;Signal Pathway;Signal Transduction;Skeletal Muscle;Somatostatin;stem cell proliferation;Stromal Cells;subcutaneous;System;Tissues;Transgenic Organisms;Visceral

PROJECT_TITLE: Intestine to adipose tissue interorgan communication in homeostasis and obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Hormetic stress leads to organismal benefits in many organisms, including via induction of the cell-recycling process of autophagy. However, it remains unclear how autophagy is induced after hormetic stress and whether autophagy is sustained to manifest long-term organismal benefits. Since autophagy and stress- response hormesis are evolutionarily conserved, the proposed research to investigate how hormetic stress regulates autophagy is relevant to human health and may prove important for developing strategies to protect against human age-related diseases.

PI_NAMEs: KUMSTA, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Affect;Age;age related;age related changes;age related decline;age-related disease;Aging;aging process;animal old age;Autophagocytosis;Autophagosome;Auxins;Biochemical;biological adaptation to stress;Biological Assay;Caenorhabditis elegans;Cell Nucleus;Cells;Cellular Stress;Cytoprotection;cytotoxic;Data;Data Analyses;Dermal;design;Disease;Dissociation;Ensure;Exposure to;Fibroblasts;fitness;Functional disorder;Future;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Health;Health Promotion;healthspan;heat-shock factor 1;Heat-Shock Response;Helix-Turn-Helix Motifs;Homeostasis;Human;improved;in vivo;innovation;insight;Intervention;Lead;Life;Link;Longevity;Lysosomes;Mediating;Metabolic;Modeling;Molecular;novel therapeutic intervention;Nuclear Import;Nuclear Translocation;nucleocytoplasmic transport;nutrient deprivation;Organism;Orthologous Gene;Positioning Attribute;prevent;Process;protective effect;protein aggregation;proteostasis;Protocols documentation;Recycling;Regulation;Research;Resolution;response;RNA interference screen;Role;Shapes;single-cell RNA sequencing;spatiotemporal;Stress;stressor;Structure;System;Therapeutic;therapeutic development;Therapeutic heat application;Time;Tissue Differentiation;Tissues;Transcript;transcription factor;Transcriptional Regulation;whole genome;Work

PROJECT_TITLE: Hormetic regulation of autophagy in aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Pediatric radiation-induced gliomas (RIG) are understudied, uniformly fatal brain cancers that arise as a result of therapeutic cranial radiation given for other childhood cancers. We have established key molecular features that differentiate these tumors from other pediatric high-grade gliomas, as well as a set of novel patient-derived models. In this project, we will use these resources to advance understanding of germline risk factors for RIG, oncogenesis, and translatable treatment strategies.

PI_NAMEs: GREEN, ADAM LYON (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Affect;Astrocytes;Biological;Brain Neoplasms;cancer therapy;Cancerous;candidate validation;Cell Culture Techniques;Cell Line;cell type;Cells;Cephalic;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;Childhood Brain Neoplasm;Childhood Glioma;chromothripsis;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;Copy Number Polymorphism;Cranial Irradiation;Data;Data Sources;Defect;Dependence;DNA;DNA Repair;DNA Repair Inhibition;DNA Sequence Alteration;DNA sequencing;effective therapy;Effectiveness;Epidemiology;experience;FDA approved;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Profiling;genetic risk factor;genetic variant;Genomic approach;Genomics;Germ Lines;Glioma;Goals;Histologic;improved outcome;In Vitro;in vivo;Incidence;individualized medicine;inhibitor;Knowledge;Laboratory Finding;Lead;Leadership;leukemia;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;MEKs;Mesenchymal;Modality;Modeling;Molecular;Mutation;neoplastic cell;novel;novel strategies;oligodendrocyte progenitor;Oncogenic;Pathway interactions;patient derived xenograft model;patient registry;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;Pre-Clinical Model;Predisposition;Prevention;Prevention strategy;Primary Brain Neoplasms;Proliferating;Property;Radiation;radiation during childhood;Radiation Induced DNA Damage;radiation risk;Radiation therapy;Recurrence;Research;Resistance;Resources;Risk;Risk Factors;Route;Sampling;screening;Second Primary Cancers;single-cell RNA sequencing;small hairpin RNA;Somatic Mutation;standard of care;stem cell model;Subgroup;Techniques;Testing;Therapeutic;therapy resistant;transcriptome sequencing;translatable strategy;Translating;Treatment Efficacy;treatment planning;treatment strategy;tumor;tumor growth;tumorigenesis;Validation;Variant;Xenograft procedure;young adult

PROJECT_TITLE: Determining the Origins and Vulnerabilities of Pediatric Treatment-Induced Gliomas

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Evasion of core cell death pathways is a “hallmark” of cancer. The PI has consistently made highly impactful contributions to our understanding of the fundamental mechanisms of regulated cell death, especially in the areas of apoptosis and necroptosis. The project described in this application will significantly extend this understanding, and how it relates to cancer.

PI_NAMEs: GREEN, DOUGLAS R. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Allografting;Apoptosis;Apoptotic;Area;Arithmetic;cancer cell;Caspase;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;DNA Damage;DNA Sequence Alteration;Equation;Future;Generations;Genome Stability;Goals;Human;in vivo;Laboratories;Life;Lytic;Malignant Neoplasms;Membrane;Molecular;Near-Death Experience;Necrosis;Pathology;Pathway interactions;prevent;Process;programs;Property;Regulation;repaired;Research;Residual Neoplasm;Resistance;resistance mutation;Stimulus;success;Survivors;Testing;Therapeutic;Tissues;tool;Work;Xenograft Model

PROJECT_TITLE: MECHANISMS OF REGULATED CELL DEATH

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Estrogen;Heart Disease;Lung;Pulmonary Hypertension;Women's Health Research

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will determine the underlying mechanisms of how estrogen receptor α improves right heart function in pulmonary hypertension, a progressive cardiopulmonary disease that is caused by thickening of the blood vessels of the lung and that leads to premature death from right heart failure. No cure for pulmonary hypertension is available, and no specific therapies for right heart failure exist. The proposed work is relevant to the mission of the NHLBI, since it will lead to the development of novel treatments for both male and female patients with right heart failure from pulmonary hypertension or other cardiopulmonary diseases.

PI_NAMEs: LAHM, TIM  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Agonist;Animal Model;APLN gene;ATAC-seq;Attenuated;Binding;Biology;Biomechanics;Blood Vessels;bone morphogenetic protein receptors;Calcium Signaling;Cardiac Myocytes;Cell Physiology;Cessation of life;clinically relevant;Combined Modality Therapy;Complement;Coupling;Data;Development;Echocardiography;ESR1 gene;Estradiol;estrogenic;Estrogens;exercise capacity;Exhibits;experimental study;Exposure to;Female;Functional disorder;Funding;Goals;Gonadal Steroid Hormones;Harm Reduction;Heart;heart function;Human;improved;in vivo;induced pluripotent stem cell;Inflammasome;Inflammatory;inhibitor;innovation;Knowledge;Link;loss of function;Lung;Macrophage;male;Measures;Mediating;Mediator;Mission;Modeling;Muscle;mutant;National Heart, Lung, and Blood Institute;novel;Pathway interactions;Patients;porcine model;Postmenopause;premature;Premenopause;pressure;prevent;Process;promoter;Public Health;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Pump;Rattus;receptor;Regional Perfusion;Research;resilience;right ventricular failure;Right ventricular structure;Rodent;sex;Sex Differences;sexual dimorphism;Signal Transduction;Structure;Survival Rate;Testing;Therapeutic;Therapeutically Targetable;Time;Tissues;transcription factor;Treatment Efficacy;women patients;Women's Rights;Work

PROJECT_TITLE: Mechanisms of right ventricle adaptation to pulmonary hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-M (03)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Stroke

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The proposed study investigates how cerebral aneurysm treatment outcome can be predicted through computer simulations. Typical simulations do not account for clotting factors in the blood, which are important in determining which treatments succeed and which fail. We will incorporate these aspects into computer simulations and validate them with an animal model of cerebral aneurysms for cerebral aneurysm treatment outcome prediction. This project has an impact on public health by improving the prevention of hemorrhagic stroke from aneurysm rupture and improving treatment.

PI_NAMEs: LEVITT, MICHAEL ROBERT (contact)

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Aftercare;Aneurysm;Animal Model;Attention;Blood;Blood Coagulation Factor;Blood flow;Blood Platelets;blood product;Blood Vessels;Brain hemorrhage;Cerebral Aneurysm;cohort;Computer Models;Computer Simulation;Decision Making;Devices;Environment;experience;Failure;Feasibility Studies;Funding;Goals;healing;hemodynamics;Histologic;holistic approach;Human;improved;In Vitro;innovation;Liquid substance;Methodology;Methods;Modeling;novel;outcome prediction;particle;Patients;Prevalence;Prevention;Prognosis;Public Health;Recording of previous events;Recurrence;residence;Retreatment;Risk;Role;Rupture;Ruptured Aneurysm;simulation;success;Therapeutic Embolization;Thrombosis;Thrombus;Time;Treatment Failure;Treatment outcome;treatment risk;United States National Institutes of Health

PROJECT_TITLE: Computational modeling of platelets and thrombosis in cerebral aneurysm treatment


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Women's Health Research

PHR: NARRATIVE This proposal aims to study a novel protein, EndoU, that binds and cleaves cellular RNAs and is associated with many epithelial cancer types. EndoU is unique among its class of RNA-binding proteins and RNA endonucleases in that its cleavage activity is activated by calcium ions, an important signaling molecule in the cell, suggesting that it functions in the cellular response to this signal. Our study will provide a thorough understanding of EndoU function at the cellular and molecular levels, and enable further studies of its role in squamous epithelium and placental tissues, as well as its role in cancer development.

PI_NAMEs: KARGINOV, FEDOR V (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Affect;anti-cancer;Apoptosis;Apoptotic;Automobile Driving;B-Lymphocytes;Binding;Biochemical;Biological;Biological Assay;Calcium;Calcium ion;cancer type;Carcinoma;Catalysis;Catalytic Domain;Cell Culture Techniques;Cell Death Induction;Cell Line;Cell Physiology;cell type;Cells;Cervical;Colorectal Cancer;Cytoplasm;Data;Dependence;Development;Disease;Endoribonucleases;Enzymes;Epithelial Cells;Esophagus;Event;experimental study;extracellular;Family;Goals;Head Cancer;Homologous Gene;Human;In Vitro;in vivo;innovation;Investigation;Ions;Knowledge;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Messenger RNA;Methods;Modeling;Molecular;Molecular Conformation;Mus;Neck Cancer;novel;nuclease;Oral;Outcome;Pattern;Peripheral;Placenta;Population;Positioning Attribute;Process;Prognostic Marker;Proteins;rational design;Receptor Activation;Recombinants;Regulation;Research;response;Ribonucleases;Ribosomal RNA;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Second Messenger Systems;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;Skin;Small Nuclear RNA;Sorting;Specificity;Squamous Cell Lung Carcinoma;Squamous Epithelium;Stimulus;Structure;Syncytiotrophoblast;T-Cell Receptor;Testing;thymocyte;Thymocyte Development;Tissues;transcriptome sequencing;Transfer RNA;Translations;Uterus;Viral

PROJECT_TITLE: Function and mechanism of EndoU

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Infectious Diseases;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Immune responses to checkpoint blockade therapy in patients with malignant melanoma depend upon self- renewing T cells. The goal of this project is to identify mechanisms that underlie the regulation these cells based on a novel immunotherapy to ultimately promote better long-term patient outcomes.

PI_NAMEs: BRADLEY, LINDA MAC PHERSON (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Aftercare;Animals;anti-PD-1;Antibodies;Antigens;Antitumor Response;Automobile Driving;Binding;Blood;Cancer Patient;CD8-Positive T-Lymphocytes;Cells;Characteristics;Chronic;Clinical;clinical translation;CTLA4 gene;Development;effector T cell;Epigenetic Process;exhaust;exhaustion;Frequencies;Generations;Genes;Genetic Transcription;Glycoproteins;Goals;Histologic;Histology;Homologous Gene;Human;Human Cloning;humanized mouse;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunotherapy;improved outcome;In Vitro;in vivo;Industry;Infection;Inflammation;Lead;Leukocytes;Ligands;Lymphocytic choriomeningitis virus;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;migration;Modeling;Monoclonal Antibodies;mouse model;Mus;neoplastic cell;novel;Outcome;P-Selectin;P-selectin ligand protein;Pathway interactions;patient response;patient subsets;Patient-Focused Outcomes;Patients;PD-1 blockade;Phenotype;predicting response;prevent;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;receptor;Regulation;Reporter;Resistance;response;Sampling;self renewing cell;self-renewal;Signal Transduction;stemness;synergism;T cell differentiation;T cell response;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;TCF Transcription Factor;Testing;Therapeutic;Time;Toxic effect;translational potential;treatment effect;tumor;tumor growth;tumor microenvironment;Up-Regulation;Virus Diseases

PROJECT_TITLE: Rewiring T cell exhaustion with immune checkpoint blockade therapy

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Over half a million U.S. patients have implantable pacemakers, with the prevalence of this procedure rising from 0.4 per 1,000 among persons ages 18-64 to 26 per 1,000 among those ages 75 or order. Despite advancements in implantable cardiac pacemaker technology over the past 5 decades, many implants, including leadless pacemakers, are still associated with lead-related complications. To ameliorate these limitations, we seek to develop the smallest (2 mm x 10 mm), lightweight (5 mg), and flexible bioelectronics that can be navigated in the tortuous cardiovascular anatomy for implantation into the anterior cardiac vein to stimulate electrical conduction and myocardial contraction.

PI_NAMEs: HSIAI, TZUNG K (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: absorption;Acute;Address;Age;aging population;Algorithms;Anatomy;Anterior;Biocompatible Materials;bioelectronics;biomaterial compatibility;Blood Vessels;Cardiac;cardiac implant;Cardiac pacemaker;Cardiac Tamponade;cardiac vein;Cardiovascular system;Catheters;Chronic;Clinical;Coagulation Process;Coronary sinus structure;Defect;design;Devices;electric impedance;Electric Stimulation;Electric Stimulation Therapy;Electrodes;Epicardium;Failure;Family suidae;flexibility;Food;Fracture;Funding;gastrointestinal;Heart;Hematoma;Human;Implant;implantation;in vivo;Incidence;Infection;Lead;light weight;Longevity;mechanical properties;meetings;Microbial Biofilms;microelectronics;minimally invasive;Modeling;Musculoskeletal;Myocardial;Myocardial Contraction;Myocardium;neural;Neurologic;Pacemakers;Patients;Perforation;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physiologic pulse;Pneumothorax;porcine model;Positioning Attribute;Prevalence;Procedures;radio frequency;response;Right ventricular structure;Safety;Series;Specific qualifier value;Stomach;Structure;subcutaneous;System;Technology;Testing;thrombotic;Tissues;Tubular formation;United States;United States Food and Drug Administration;urologic;Veins;Venous;Ventricular;wireless

PROJECT_TITLE: Intravascular Deployment of a Wirelessly Powered Micro-Pacer

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: MERCED

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: The pre-clinical studies outlined in this proposal have the potential to elucidate the role of endothelial cells and the blood vascular system in normal thymus function and during regeneration in ways that have not been previously possible through use of novel imaging methods and techniques for direct thymus evaluation. These techniques could be applied to a whole range of studies related to adaptive immunity including graft vs. host disease, age-related loss of thymic function, and cancer. The knowledge gained in this proposal may enable the development of improved therapies for treatment of hematologic malignancies and other cytotoxic therapies.

PI_NAMEs: SPENCER, JOEL A. (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Acute leukemia;Adaptive Immune System;adaptive immunity;Address;Adult;Affect;age related;Aging;Anatomy;Animals;Blood;Blood flow;Blood Vessels;BMP4;Bone Marrow;cell behavior;Cell Compartmentation;Cell surface;Cells;chemotherapy;Clinical Data;conditioning;cytotoxic;Cytotoxic Chemotherapy;Data;Data Set;Development;Diameter;Dose;Dysmyelopoietic Syndromes;Endothelial Cells;Engraftment;Evaluation;Flow Cytometry;Genes;graft vs host disease;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;hemodynamics;Heterogeneity;high resolution imaging;Image;imaging modality;imaging system;Imaging Techniques;Immune system;improved;in vivo;in vivo imaging;Infection;Injury;insight;intravital imaging;intravital microscopy;Investigation;Knowledge;Ligands;Lymphoma;Malignant Neoplasms;Methods;microendoscope;Microscopy;minimally invasive;Morbidity - disease rate;mortality;Multiple Myeloma;Mus;Natural regeneration;new therapeutic target;novel;novel imaging technique;Organ;Oxygen;Permeability;phosphorescence;Physiological;Physiology;preclinical study;preconditioning;progenitor;radioresistant;Recovery;recruit;regenerative;Regimen;Resolution;response;restoration;Role;single-cell RNA sequencing;Site;Sorting;stem cells;Stromal Cells;Structure;Structure of thymic cortex;success;Techniques;Testing;thymic regeneration;Thymus Gland;Time;Tissue Donors;tissue oxygenation;Tissues;tool;Transplantation;two photon microscopy;two-photon;Vascular Endothelial Cell;Vascular System;Whole-Body Irradiation;Work

PROJECT_TITLE: Understanding the role of the blood vascular system and endothelial cells in early thymus regeneration after cytotoxic treatments using novel intravital imaging techniques

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Mental Health;Pain Research;Palliative Care;Prevention;Sleep Research

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Insomnia and related symptoms (e.g., fatigue, distress, pain) that worsen insomnia are common, distressing, and persistent for patients in the hospital receiving high-dose chemotherapy for life-threatening hematologic cancer. Insomnia and symptom management during and following intensive inpatient treatment is urgently needed for this high-risk cancer population and represents a key NIH/NCI initiative; yet, this is a neglected area of research as there are limited insomnia and symptom management protocols that comprehensively address the challenging treatment course (i.e., inpatient, outpatient) and symptom demands (e.g., insomnia, fatigue, distress, pain) faced by hematologic cancer patients. A pilot randomized controlled trial will assess the feasibility, acceptability, engagement, and outcome patterns of a mindfulness-based insomnia and symptom management intervention bridging inpatient and outpatient settings to improve cancer morbidity in a vulnerable yet understudied cancer population.

PI_NAMEs: FISHER, HANNAH M (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adherence;Anxiety;Area;Arousal;Behavior;Behavior Therapy;Behavioral;Behavioral Sciences;Cancer Patient;cancer therapy;Caring;Circadian Rhythms;Clinical Trials Design;Data;design;Disease;Disease Outcome;Disease remission;Distress;Doctor of Philosophy;Dose;Ear;Education;Educational process of instructing;Environment;experience;Fatigue;Fellowship;Future;Goals;Hematologic Neoplasms;High Dose Chemotherapy;High-Risk Cancer;Home;Hospitalization;Hospitals;Impairment;improved;improvement on sleep;Inflammation;Inpatients;Intervention;Interview;Life;Malignant Neoplasms;Masks;Medical Device;Mentorship;mindfulness;mindfulness intervention;mindfulness meditation;mobile application;Modeling;Morbidity - disease rate;neglect;Outcome;Outpatients;Pain;pain symptom;Participant;Patient Discharge;patient population;Patients;Pattern;Pharmaceutical Preparations;Phase;Physiological Processes;poor sleep;Population;post intervention;Precipitating Factors;preference;primary outcome;Procedures;professor;Protocols documentation;Psychiatry;psychosocial;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;satisfaction;Schedule;secondary outcome;Self Efficacy;Sequential Multiple Assignment Randomized Trial;Severities;skills;Sleep;Sleep disturbances;sleep quality;Sleeplessness;Statistical Methods;Stimulus;success;Symptom Burden;symptom management;symptom self management;Symptoms;telehealth;Testing;therapy development;tool;Training;treatment as usual;Treatment Protocols;treatment strategy;trial design;understudied cancer;United States National Institutes of Health;Work

PROJECT_TITLE: Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Maternal Health;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative At the height of the 2015-2016 epidemic in Brazil, there were an estimated 50 cases of CZS per 1000 live births (1:200), equal to the incidence of all other birth defects combined. Longitudinal studies of babies born to ZIKV- infected mothers have reported that motor deficits, cognitive defects, and learning retardation may appear later in life, even if the babies were asymptomatic at birth. This project aims to develop a ZIKV vaccine that provides effective protection against transplacental transmission of ZIKV.

PI_NAMEs: SHRESTA, SUJAN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Allogenic;Antibodies;Antibody Response;Antibody titer measurement;Antibody-Dependent Enhancement;Antigens;ATAC-seq;Biology;Birth;Brazil;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Child;Cognitive deficits;Collaborations;Congenital Abnormality;congenital zika syndrome;Cytoprotection;Data;Dengue Vaccine;Dengue Virus;design;Enzyme-Linked Immunosorbent Assay;Epidemic;Exhibits;Exposure to;Female;fetal;Fetal Weight;Fetus;Flavivirus;Genomics;Goals;Granzyme;Haplotypes;Height;Histopathology;Human;Humoral Immunities;Immune response;Immunity;Immunization;improved;in utero;Inbred BALB C Mice;Incidence;Individual;Infection;insight;Learning;Life;Live Birth;Longitudinal Studies;male;maternal serum;Maternal-Fetal Exchange;Maternal-Fetal Transmission;Mediating;Membrane;Modeling;Molecular Profiling;Mothers;motor deficit;mouse model;Mus;neonate;Neurodevelopmental Impairment;Neutralization Tests;neutralizing antibody;Nonstructural Protein;novel;novel strategies;OX40;Pathogenesis;Pathology;Pathway interactions;perforin;Persons;Placenta;Pregnancy;pregnant;Pregnant Women;Protocols documentation;Public Health;Publishing;Replicon;Reporting;Risk Factors;RNA vaccine;Role;Safety;Serum;severe COVID-19;single-cell RNA sequencing;T cell response;T-Cell Depletion;T-Lymphocyte;Testing;Tissues;TNF gene;transmission process;Vaccinated;vaccination protocol;Vaccine Antigen;vaccine development;vaccine efficacy;vaccine-induced immunity;Vaccines;Viral;Viral Load result;Virus Diseases;virus host interaction;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: A novel strategy for vaccine-induced protection against maternal-to-fetal transmission of Zika virus

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  East Africa (EA) has, historically, contributed minimally to the conditions that exacerbate climate change (CC), yet the region is one of the most vulnerable to the effects of CC and related extreme weather events (EWEs), and this has implications for vulnerable communities' health and well-being in the region. The goal of the Anga Center for Climate Justice, Health Equity, and Community Well-being is to improve climate justice, health equity, and community well-being by exploring climate-related health and well-being and interventions to strengthen them through building transdisciplinary research capacity and fostering sustained community engagement and empowerment in climate vulnerable communities and marginalized populations. The Center will bring funding for CC and health research directly into a region that has been historically underfinanced and expected to experience worse health impacts from CC and expands capabilities of climate vulnerable communities to be engaged with, guide, and co-produce CC and health research, climate adaptive strategies, and interventions that minimize vulnerability to CC and improve overall health and well-being.

PI_NAMEs: NDETEI, DAVID MUSYIMI;WINTER, SAMANTHA C. (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adverse effects;Affect;Africa;Alcohol abuse;Biometry;career;Child;Climate;climate adaptation;climate change;climate crisis;climate impact;climate science;climate variability;climate zone;climate-related health;Communities;community based participatory research;Community Developments;community empowerment;community engaged research;community engagement;Community Health;community partnership;Conflict (Psychology);coping;Country;Data;Data Collection;disability;Disease;Droughts;Drug abuse;Ensure;environmental change;Environmental Engineering technology;Environmental Science;Equity;Ethics;Event;Exclusion;experience;Exposure to;extreme temperature;extreme weather;Face;Feeling suicidal;Floods;Fostering;Fright;Funding;Gender;Goals;Grief reaction;Health;health equity;health inequalities;Health Sciences;Heart;Heat Waves;improved;Infrastructure;Intervention;Investments;Justice;Knowledge;Land Tenure;Legal;Literature;low income country;marginalization;marginalized population;Mental Health;Methodology;mortality;Outcome;Pathway interactions;Personal Satisfaction;Persons;Policy Maker;Politics;Positioning Attribute;Poverty;Precipitation;Predisposition;Psychiatry;Public Health;Rain;Recording of previous events;Research;Research Personnel;Research Priority;Research Project Grants;Science;Scientist;Seasons;Services;skills;social;Social Work;System;systems research;Technical Expertise;Training;trend;Violence;vulnerable community;Woman;Work

PROJECT_TITLE: Anga Center for Climate Justice, Health Equity, and Community Wellbeing


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MUSYIMI, CHRISTINE WAYUA (contact)

PROJECT_TITLE: Anga Center Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PI_NAMEs: WINTER, SAMANTHA C. (contact)

PROJECT_TERMS: Accounting;Acute;Adverse effects;Affect;Africa;Area;burden of illness;Climate;climate change;climate data;climate variability;climate-related health;Communication Methods;Communities;community engaged research;community engagement;community intervention;Conflict (Psychology);coping;cost;Country;Data;Data Collection;Depressive disorder;Development;Droughts;Economics;environmental change;Event;Exclusion;experience;Exposure to;extreme temperature;extreme weather;Face;farmer;Farming Community;Feeling suicidal;Floods;Foundations;Frequencies;Fright;Future;Geography;Grief reaction;hazard;Health;health equity;Heat Waves;Hour;Household;improved;Interpersonal Violence;Intervention;intimate partner violence;Justice;Kenya;Land Tenure;Legal;low income country;marginalization;Measures;Mental disorders;Mental Health;meteorological data;Outcome;Participant;Pathway interactions;Personal Satisfaction;Persons;Politics;Population;Poverty;Precipitation;Predisposition;Prevalence;prevent;Psychosocial Stress;Rain;Randomized;Randomized, Controlled Trials;Readiness;Reporting;Research;Research Project Grants;Seasons;Services;social;Suicide attempt;Surveys;System;Tanzania;Telephone;Temperature;Testing;Text;trend;Uganda;vector;Violence;vulnerable community;Weather;weather stations;Well in self;Woman;years lived with disability

PROJECT_TITLE: Investigating pathways between climate and mental health and wellbeing and development and testing of localized, impact-based early warning systems for climate vulnerable communities in East Africa


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MUHANGUZI, FLORENCE KYOHEIRWE (contact)

PROJECT_TERMS: Adaptation research;Address;Affect;Africa;African;Climate;climate adaptation;climate change;climate crisis;climate zone;climate-related health;Clinical;Collaborations;Communities;community based participatory research;community center;community empowerment;community engagement;Community Health Aides;community partnership;community research;Conscious;Country;Data;design;digital;Disabled Children;Disabled Persons;Economics;Education;Educational process of instructing;Employment Opportunities;empowerment;Ensure;environmental change;Equity;Event;evidence base;extreme temperature;extreme weather;Familiarity;Farming Community;Feedback;Fostering;Gender;global health;Goals;Government;hazard;Health;health equity;Health Sciences;Household;improved;Individual;Institution;Intervention;Justice;Kenya;marginalized population;meetings;member;Mission;Outcome;Personal Satisfaction;Philosophy;Policies;Policy Developments;Policy Maker;Population;Positioning Attribute;Precipitation;Process;Program Development;Reporting;Research;research and development;Research Design;Research Ethics;Research Methodology;Research Project Grants;Resources;Services;success;Supervision;Surveys;symposium;System;Tanzania;theories;tool;Training;Translating;Translations;Uganda;Voice;vulnerable community;Wages;weather stations;women with disabilities;Work

PROJECT_TITLE: Anga Center Community Collaborative Core


PI_NAMEs: MUITA, RICHARD R (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;Africa;Attention;Belief;career;Climate;climate adaptation;climate change;climate crisis;climate data;climate impact;climate science;climate variability;climate zone;climate-related health;cohort;Collaborations;Communities;coping;cost;Data;data management;Dedications;disability;doctoral student;Educational workshop;Ensure;Equity;Extramural Activities;farmer;Fellowship;Fostering;Funding;Future;Goals;hands on research;Health;health equity;Health Sciences;improved;Indigenous;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Justice;Knowledge;knowledge integration;Learning;low income country;marginalized population;member;Mentorship;Modernization;Monitor;multidisciplinary;Nature;Pathway interactions;Personal Satisfaction;Persons;Pilot Projects;Population;Predisposition;Production;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Science;Scientist;skills;Source;Textiles;Training;Training Programs;Universities;usability;vulnerable community;Vulnerable Populations;Weather;weather stations;Woman;Work;Youth

PROJECT_TITLE: Anga Center Capacity Building Core


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: Lower extremity peripheral artery disease (PAD) impacts over 200 million patients worldwide and is associated with high morbidity and mortality. The results of the multinational LEADER-PAD trial (1000 US participants) will provide the first evidence regarding the role of the anti-inflammatory drug colchicine in the treatment of PAD.

PI_NAMEs: PATEL, MANESH R (contact);RYMER, JENNIFER

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acute;Address;Adherence;Advocate;Affect;American;Amputation;Anti-Inflammatory Agents;Atherosclerosis;Black American;Blood Vessels;C-reactive protein;Canada;Cardiovascular system;Caring;Cessation of life;Chronic;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Colchicine;Coronary Arteriosclerosis;Coronary heart disease;cost;cost effectiveness;Country;Creatinine;Creativeness;Data Coordinating Center;Data Sources;Diagnosis;Diarrhea;Disease;Dose;Double-Blind Method;efficacy evaluation;Enrollment;Ethnic Origin;EuroQOL;Event;experience;FDA approved;follow-up;functional status;Funding;gastrointestinal;Guidelines;Health;health difference;health related quality of life;Hospitalization;implementation research;improved;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;innovation;Inpatients;International;Intervention;Ischemia;Leadership;limb ischemia;Limb structure;Lipids;Lower Extremity;Malignant Neoplasms;Measurement;Measures;Medical;medication compliance;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nausea and Vomiting;novel diagnostics;novel therapeutic intervention;Outcome;Outcome Study;pandemic disease;Participant;Pathogenesis;Patient Care;Patients;Peripheral arterial disease;Pharmaceutical Preparations;Placebo Control;Placebos;Population;population health;prevent;primary endpoint;Quality of life;Race;Randomized;Research Institute;Research Personnel;Residual state;revascularization;Risk;Risk Reduction;Role;Safety;safety outcomes;secondary endpoint;sex;Site;Specific qualifier value;Strategic vision;Stroke;Subgroup;symptom treatment;systematic review;Telephone;Testing;Thromboembolism;Toxic effect;Travel;trial design;United States;Venous;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: 1/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (M1)]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: Over the past decades, healthcare systems face significant challenges to meet the needs of an aging population due to progressive debility, functional decline and chronic diseases development. While there is a growing appreciation of the potential impact of mTOR inhibitors on slowing aging processes, preventing chronic disease and prolonging healthy lifespan, a major challenge in developing clinical trials to establish the clinical efficacy of mTOR inhibitors is the absence of pharmacokinetics (PK) and pharmacodynamics (PD) data in older adults. The proposed study will provide the foundation for future clinical trials assessing the role of mTOR inhibitors on aging related indications.

PI_NAMEs: DUNN, ALLISON ;SHU, YAN ;TIMOFTE, IRINA  (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: absorption;Age;age difference;age related;Aging;aging biomarker;aging population;aging process;aging related;beneficiary;Bioenergetics;Biological Assay;Biological Markers;Blood specimen;C-reactive protein;care costs;Characteristics;Chronic Disease;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;cost estimate;Data;Debility;design;Development;disability;Dose;Drug Exposure;Drug Kinetics;Effectiveness;Enzyme-Linked Immunosorbent Assay;Epidemiologist;Erythrocyte Sedimentation Rate;Excretory function;experience;Face;follow-up;Foundations;frailty;functional decline;Functional disorder;Future;Geriatrics;Gerontology;Goals;Health;Healthcare Systems;healthspan;healthy volunteer;human old age (65+);Immunosuppression;Impairment;improved;In Vitro;indexing;individual patient;Investigation;Knowledge;Measurement;Measures;Medicare;Metabolism;Methods;Mitochondria;model development;Modeling;Molecular;mTOR Inhibitor;multidisciplinary;novel therapeutic intervention;older adult;Organ;Oxygen Consumption;Participant;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;phenotypic biomarker;Plasma;Population;pre-clinical;preclinical evaluation;Predisposition;prevent;Process;Public Health;Quality of life;Randomized;Research;research clinical testing;response;response biomarker;Role;Science;SDZ RAD;senescence associated secretory phenotype;Shapes;Sirolimus;Techniques;Therapeutic Intervention;Time;tool;Transplant Recipients;Transplantation;treatment duration;treatment response

PROJECT_TITLE: Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M2)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

PI_NAMEs: BANGDIWALA, SHRIKANT I;BOSCH, JACKIE ;EIKELBOOM, JOHN ;VEMULAPALLI, SREEKANTH  (contact)

PROJECT_TERMS: Acute;Address;Adherence;Advocate;Amputation;Anti-Inflammatory Agents;Blood Pressure Monitors;Blood Vessels;C-reactive protein;Canada;Cardiovascular system;Cessation of life;Chronic;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Colchicine;Collaborations;Collection;Companions;Coronary heart disease;cost effectiveness;Creativeness;Data;Data Collection;Data Coordinating Center;data integrity;data management;Data Reporting;data sharing;Data Sources;Diarrhea;Disease;Dose;Double-Blind Method;efficacy evaluation;electronic data;Enrollment;Ethnic Origin;EuroQOL;Event;experience;follow-up;functional status;gastrointestinal;Guidelines;Health;health difference;health related quality of life;Hospitalization;implementation research;improved;indexing;Individual;Infection;Inflammation;inflammatory marker;Infrastructure;innovation;International;Intervention;Ischemia;Leadership;limb ischemia;Limb structure;Lower Extremity;Malignant Neoplasms;Measures;Medical;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nausea and Vomiting;novel diagnostics;novel therapeutic intervention;Outcome;pandemic disease;Participant;Patient Care;Patients;Peripheral arterial disease;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Population;population health;Preparation;prevent;primary endpoint;Procedures;Process;protocol development;Publications;Qualifying;Quality Control;Quality of life;Race;Randomized;randomized placebo controlled trial;Reporting;Research Design;Research Institute;Research Personnel;Residual state;revascularization;Risk;Risk Reduction;Role;Safety;safety outcomes;secondary endpoint;sex;Site;Specific qualifier value;Statistical Data Interpretation;Strategic vision;Stroke;Subgroup;symptom treatment;System;systematic review;Telephone;Testing;Thromboembolism;tool;Toxic effect;Training;Travel;trial design;Venous;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: 2/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)


PHR: PROJECT NARRATIVE Immunotherapy has revolutionized cancer treatment, though a significant proportion of tumors are refractory to treatment or ultimately acquire resistance. Therefore, there is an unmet clinical need to develop new immunomodulatory drugs that can enhance the efficacy of immunotherapy in cancer treatment. A potent and selective SUV39H1 inhibitor could lead to a safe and effective therapeutic approach to augment immunotherapy responses, as well as promote stand-alone antitumor responses, through the unique mechanism of induced viral mimicry, undoubtedly leading to a significant reduction in disease mortality.

PI_NAMEs: OLSON, STEVEN H;SERGIENKO, EDUARD A.;SPRUCK, CHARLES H. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: analog;anti-tumor drug;Antitumor Response;Binding;Binding Sites;Biochemical;Biological Assay;cancer cell;Cancer Cell Growth;Cancer Model;Cancer Patient;cancer therapy;Cells;checkpoint therapy;Chemicals;Chromatin;Clinical;clinical development;Complex;cytotoxic;Data;design;Development;Disease;DNA replication fork;Dose;Drug Design;Dryness;Endogenous Retroviruses;Enzymes;Epigenetic Process;Exhibits;Fluorescence Resonance Energy Transfer;Gene Silencing;Genetic Transcription;Goals;high throughput screening;histone methyltransferase;immune modulating agents;Immune response;Immune system;Immunologics;Immunomodulators;Immunooncology;immunoregulation;Immunotherapy;in vivo;Infiltration;inhibitor;Interferons;Lead;Ligand Binding;Mediating;mimicry;mortality;Mus;Natural Killer Cells;Nivolumab;Normal Cell;novel;novel strategies;novel therapeutic intervention;Pathway interactions;pembrolizumab;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Powder dose form;pre-clinical;preclinical study;Property;Readiness;Refractory;refractory cancer;Regulatory Pathway;replication stress;Research;Resistance;response;Retrotransposon;Robotics;scaffold;Series;Signal Transduction;small molecule libraries;Structure;synergism;Testing;Therapeutic;therapeutically effective;tumor;Viral;Virus

PROJECT_TITLE: Discovery of Potent Selective Inhibitors of the Histone Methyltransferase SUV39H1 for the Treatment of Cancer

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: 3D imaging is rapidly replacing 2D planar images in radiology. We aim to create a model with radiologist-like vision that learns to best search and scroll through 3D volumes. The model can be used to identify inefficiencies in radiologists' search/scroll strategies and mitigate search errors, and as a tool to evaluate and optimize the quality of 3D medical imaging technology.

PI_NAMEs: ECKSTEIN, MIGUEL PATRICIO (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Adopted;Adoption;Anatomy;Architecture;Area;Back;Behavior;Benign;Binding;Breast Microcalcification;Clinic;Clinical;clinical imaging;Clinical Trials;Collaborations;cost;Data;Databases;Death Rate;deep neural network;Detection;Development;diagnostic accuracy;digital;Digital Breast Tomosynthesis;Disease;Early Diagnosis;Evaluation;Eye Movements;Feedback;gaze;Goals;Health system;Human;human model;Image;image processing;Imaging technology;improved;Industry;Learning;Lesion;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Measures;Medical Imaging;Modeling;Modernization;new technology;Noise;Pathology;Pattern;Pennsylvania;Performance;Peripheral;pre-trained transformer;Procedures;programs;Protocols documentation;Psychological reinforcement;radiation mitigation;radiologist;Radiology Specialty;Reading;Research Personnel;sample fixation;Scanning;Shapes;Signal Transduction;Slice;Source;spatiotemporal;Techniques;Technology;theories;Three Dimensional Medical Imaging;Three-Dimensional Image;Three-Dimensional Imaging;tool;Training;United States Food and Drug Administration;Universities;virtual clinical trial;virtual imaging;Vision;vision science;visual processing;visual search;Work

PROJECT_TITLE: Visual Search in 3D Medical Images

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-P (03)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

PHR: This VHA Career Development Award will ensure Dr. Hayes’s expertise in translating knowledge gained from electronic health record (EHR) data and predictive analytics (e.g., predicting the future probability of an outcome for individuals) into interventions that increase Veterans’ retention in medication treatment for opioid use disorder (MOUD; e.g., buprenorphine). His specific training areas span the spectrum of learning advanced methods for working with EHR data, how to develop computer-based tools, and how to test the effectiveness of new interventions. Dr. Hayes will apply this new knowledge to (a) develop a mathematical model that will continuously assess Veterans’ risk of discontinuing MOUD, (b) create a computer-delivered clinical tool that provides clinicians with information (i.e., patient-specific likelihood risk, patient-specific risk factors for discontinuing MOUD, and treatment guidelines, when indicated) on Veterans’ risk of discontinuing MOUD, and (c) test the feasibility/acceptability of the clinical tool among VHA providers who are prescribing buprenorphine.

PI_NAMEs: HAYES, COREY J (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Area;arm;Artificial Intelligence;artificial intelligence method;Automobile Driving;Big Data;Big Data Methods;big-data science;Buprenorphine;Businesses;care systems;career;Caring;Clinical;clinical decision support;comorbidity;Computers;Counseling;Data;Data Analytics;Data Science;data warehouse;design;Diagnosis;Discrimination;Dose;Drug usage;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;Enrollment;Ensure;experience;Feasibility Studies;feasibility testing;feedforward neural network;Focus Groups;follow-up;Frequencies;Future;Guidelines;Health Services Accessibility;Healthcare;high risk;Homogeneously Staining Region;Hybrids;illicit drug use;implementation science;improved;improved outcome;Individual;Informatics;innovation;Intelligence;interest;Intervention;K-Series Research Career Programs;Knowledge;Learning;Logistic Regressions;machine learning method;mathematical model;Measures;medical specialties;medication for opioid use disorder;Mental Health;Methadone;Methodology;Methods;military veteran;Modeling;modifiable risk;Monitor;mortality;Naltrexone;neural network;operation;Opioid;opioid overdose;opioid use disorder;Outcome;Overdose;overdose risk;Pain;Pain management;Patients;peer support;Persons;Pharmaceutical Preparations;Pharmacy facility;pilot test;pilot trial;Predictive Analytics;predictive modeling;prevent;Primary Care;Probability;Provider;random forest;Randomized, Controlled Trials;Reporting;Research;Research Priority;Resources;Risk;Risk Factors;Sampling;Services;Site;skills;standard of care;statistics;Substance Use Disorder;Suicide;support tools;Techniques;Testing;Time;tool;Training;Translating;treatment guidelines;treatment planning;usability;Veterans;Visit;waiver

PROJECT_TITLE: Data to Clinical Action: Using Predictive Analytics to Improve Care of Veterans with Opioid Use Disorder

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: LEEDS

ORG_NAME: NORTHAMPTON VA MEDICAL CENTER

ORG_STATE: MA

PHR: Over the past two decades, an increasing number of Veterans have used VA maternity benefits for their pregnancy care. As part of the VA maternity care benefit, Veterans are provided a maternity care coordinator (MCC) to aid in their navigation of health care services both inside and outside of the VA during their pregnancies. While the MCC program offers support to women during pregnancy, racial and ethnic disparities remain in delivery outcomes and in pregnancy, labor, and delivery support among Veterans. This study examines the impact of the social determinants of health among Veterans’ of color enrolled in VA maternity care and who also had a cesarean delivery. We will use these findings to inform a pilot intervention that seeks to enhance the MCC model with doula services in effort to provide continuous pregnancy support for Veterans at the greatest risk for cesarean delivery.

PI_NAMEs: MATTOCKS, KRISTIN M. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;attenuation;Behavioral;Birth;black women;care coordination;Caring;Cesarean section;Childbirth;Chronic stress;Clinical;Color;Communities;Congresses;cost;Data;Development;Discipline of obstetrics;Discrimination;Disparate;Disparity;disparity reduction;Education;Educational process of instructing;Enrollment;Ensure;ethnic disparity;ethnic minority;Ethnic Minority Women;experience;feasibility testing;Frequencies;Future;Grant;Health;health care availability;health care service;health disparity;health equity;Hospitals;implementation outcomes;improved;Individual;Inequality;Influentials;innovation;Institution;Intervention;Interview;Investigation;Leadership;Link;Maternal Health;maternal stress;Medical;Methodology;Methods;Modeling;Not Hispanic or Latino;novel;Obstetric Delivery;Outcome;Perinatal;perinatal outcomes;perinatal period;postpartum care;Postpartum Period;Poverty;preference;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal;Prenatal care;Proctor framework;programs;Public Health;Quality of Care;Quality-Adjusted Life Years;racial disparity;racial minority;racial minority women;racism;Repeat Cesarean Section;Research;Risk;Risk Factors;Role;Self Efficacy;Services;social;social determinants;social health determinants;Statutes and Laws;Structure;Surveys;United States;United States Department of Veterans Affairs;Vaginal delivery procedure;Veterans;Visit;White Women;Woman;women of color;Women's Health Services;Work

PROJECT_TITLE: Engaging Veterans in Developing an Intervention to Address Racial Disparities in Cesarean Sections

STUDY_SECTION_NAME: Social Determinants of Health[HS2A]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE High cholesterol is a cardinal risk factor for cardiovascular disease, the leading cause of death worldwide. Inhibition of Angiopoietin-like protein 3 (ANGPTL3) has emerged as a therapeutic target for lowering cholesterol, especially among patients with the underdiagnosed and undertreated condition familial hypercholesterolemia (FH), but this protein’s role in modulating low-density lipoprotein cholesterol (LDL) metabolism is incompletely understood. The proposed studies aim to describe the effects of total ANGPTL3 deficiency on hepatic lipid regulation and lipoprotein assembly, thereby delineating the mechanisms by which drugs inhibiting ANGPTL3 lower LDL independently of the LDL receptor (LDLR).

PI_NAMEs: BURKS, KENDALL HELENE (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Affect;Alleles;Angiopoietins;Apolipoproteins B;blood lipoprotein;cancer cell;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cause of Death;Cell Culture System;Cell Culture Techniques;Cell secretion;Cells;Characteristics;Chemicals;Cholesterol;Cholesterol Homeostasis;Circulation;Clinical;Clinical Trials;collaborative environment;Coronary Arteriosclerosis;CRISPR/Cas technology;Culture Media;Data;derepression;Diagnosis;disorder risk;drug development;Dyslipidemias;early onset;Elements;experimental study;Familial Hypercholesterolemia;FDA approved;Fellowship;Follow-Up Studies;Future;Genes;Genetic;genome editing;Goals;Hepatic;Hepatocyte;HepG2;Homeostasis;Human;human induced pluripotent stem cells;human monoclonal antibodies;human subject;Hyperlipidemia;hypolipidemia;Impairment;improved;induced pluripotent stem cell;inhibiting antibody;insight;ion mobility;Kinetics;Knock-out;Knowledge;Label;LDL Cholesterol Lipoproteins;Lipase;lipid metabolism;lipidomics;Lipids;Lipolysis;Lipoproteins;Liver;loss of function;Loss of Heterozygosity;Mass Spectrum Analysis;Measures;Metabolism;Modeling;Molecular;Monoclonal Antibodies;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Participant;particle;Particle Size;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiologic pulse;Plasma;Play;pluripotent stem cell differentiation;Population;prevent;Production;Protein Secretion;Proteins;Publishing;Radiolabeled;Reagent;receptor;receptor function;Recommendation;Refractory;Regulation;Research;Research Personnel;Research Priority;Resources;reuptake;Risk;Risk Factors;Role;Strategic Planning;System;Testing;Therapeutic;therapeutic target;Training;transcriptome sequencing;treatment response;Triglycerides;uptake;Variant;Very low density lipoprotein;Work

PROJECT_TITLE: Effects of Genetic ANGPTL3 Deficiency on Hepatic Lipid Regulation and Lipoprotein Production


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Suicide is a national public health problem that disproportionately affects Veterans. However, the toll associated with suicide goes way beyond the death of an individual. This study addresses the problems that it is unknown how many Veterans need intervention following exposure to suicide, what types of problems should be addressed and what intervention approaches might be most beneficial. The primary objective of this study is to describe the health and functional outcomes of suicide exposure among a cohort of Veterans at particularly high risk for suicide and of priority for VA suicide prevention strategies – post-9/11 Veterans transitioning to civilian life. Our second objective is to elucidate the reasons some Veterans develop persistent problems following suicide exposure while others do not. This study starts with quantitative (which is the priority of the study) followed by qualitative data collection and analysis to explain and expand the quantitative findings. Findings can inform strategies to support Veterans affected by a suicide loss.

PI_NAMEs: SAYER, NINA A. (contact)

PROJECT_TERMS: Address;Affect;Alaska Native;American Indians;Attention;Buffers;Cessation of life;Characteristics;cohort;combat;comparison group;Data;Data Analyses;Data Collection;Death Rate;Diagnosis;Disease;effective therapy;Enrollment;Ethnic Origin;experience;Exposure to;Feeling suicidal;Foundations;functional outcomes;Grief reaction;healing;Health;health assessment;health care service;health care service utilization;Healthcare;high risk;Impairment;Individual;informal support;innovation;interest;Intervention;Interview;Knowledge;Lead;Life;Mental disorders;Mental Health;Methodology;Methods;Military Personnel;Outcome;Outcome Assessment;Pattern;Persons;Population;post 9/11;Post-Traumatic Stress Disorders;Prevalence;prevent;Prevention strategy;primary outcome;Probability;Probability Samples;Public Health;Race;racial diversity;racial minority;racial population;Recording of previous events;reducing suicide;Reporting;Research;research and development;Respondent;Risk;Risk Factors;Sample Size;Sampling;service member;service utilization;sex;Sex Differences;Social Functioning;social stigma;Social support;Sudden Death;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Surveys;Target Populations;therapy development;Time;Trauma;Veterans;virtual;Woman;Work

PROJECT_TITLE: Exposure to Suicide Among Post 9/11 Veterans: Prevalence, Correlates and Treatment Needs

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Lack of social connection—especially loneliness—is a common and powerful contributor to suicidal ideation, suicide attempts, functional decline, and even death. The COVID-19 pandemic and its long aftermath amplify risk for loneliness, health problems, and suicide as well as other causes of mortality. A population of particular concern is older adults and patients with medical or psychiatric problems who have limited engagement in treatment. Caring Contacts is an evidence-based suicide prevention intervention that can potentially help. In this project, we will conduct a clinical trial of an adaptation of Caring Contacts tailored to older Veterans who miss their VA healthcare appointments. This project will help advance scientific understanding of how, and in what ways, Caring Contacts works. It will also evaluate a timely, pragmatic, low-cost, and scalable intervention with applicability to post-pandemic treatment engagement and future disasters.

PI_NAMEs: TEO, ALAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;Age;Aging;Ambulatory Care;Appointment;Area;arm;care outcomes;Caring;Cessation of life;Clinical;Clinical Trials;comparison control;Control Groups;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;dashboard;Data;Diagnosis;Disasters;effectiveness evaluation;evidence base;experience;Feeling suicidal;follow-up;functional decline;Funding;Future;future implementation;Gender;Grant;Health;Health Resources;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Individual;innovation;Intervention;intervention refinement;Loneliness;Medical;Mental Health;Mental Health Services;Methodology;mortality;Nonpharmacologic Therapy;novel;older adult;older patient;Outcome;Outpatients;outreach;Overdose;pandemic disease;patient population;Patient Self-Report;Patients;peer;peer support;Pharmaceutical Preparations;Population;post-pandemic;pragmatic trial;Prevention strategy;preventive intervention;primary care visit;psychiatric comorbidity;Randomized, Controlled Trials;recruit;research and development;Resources;response;Risk;Scientific Advances and Accomplishments;Site;social;social health determinants;Social isolation;Social support;sociodemographics;Socioeconomic Status;Specialist;Suicide;Suicide attempt;Suicide prevention;suicide rate;Survival Analysis;Testing;Time;treatment arm;treatment as usual;treatment response;Trust;usual care arm;Veterans;whole health;Work

PROJECT_TITLE: Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

PHR: Over 40% of Veterans have obesity, a condition associated with multiple comorbidities and high healthcare costs. While lifestyle interventions addressing dietary change and physical activity produce clinically significant weight loss, many individuals experience weight regain due to decreased adherence to these changes. In this two-arm, randomized trial, Veterans with obesity and a cohabitating adult support person will be randomized to participate in a virtual weight loss intervention based on the VA’s MOVE! program with or without their support person. Those who participate with their partner will learn and practice communication and support skills. We predict that the dyadic intervention will result in greater weight loss, improved social support, and enhanced quality of life at 72 weeks compared to the patient-focused intervention. If effective, the support intervention will contribute to the identification and implementation of successful, evidence-based approaches to reduce the prevalence of obesity and associated comorbidities among Veterans.

PI_NAMEs: VOILS, CORRINE IONE (contact)

PROJECT_TERMS: Address;Adherence;Adult;arm;Behavior Therapy;Behavioral;Body Weight decreased;Cholesterol;Chronic Disease;Clinical;Clinical Trials;clinically significant;Cognitive;Collaborations;Communication;comorbidity;Counseling;Couples Therapy;dietary;Dietary intake;Early Intervention;Educational Curriculum;Educational process of instructing;efficacy evaluation;evidence base;Exercise;Expectancy;experience;Feeling;Future;future implementation;Goals;Health;Health behavior change;Health Care Costs;Health Services Research;Home;implementation evaluation;implementation outcomes;improved;indexing;Individual;innovation;insight;Intervention;intervention effect;Interview;Joints;Learning;Life Style;lifestyle intervention;Maintenance;Mediating;Mediator;Medical;Methodology;Motivation;Obesity;Outcome;Participant;Patient-Focused Outcomes;Patients;Perception;Persons;Physical activity;Prevalence;primary care practice;primary endpoint;primary outcome;Problem Solving;programs;Quality of life;Randomized;randomized trial;research and development;Risk Factors;secondary outcome;skills;Social Environment;Social Network;Social support;Spouses;success;Surveys;symposium;technology platform;theories;Thinking;Time;treatment as usual;two-arm trial;United States Department of Veterans Affairs;Veterans;virtual;virtual healthcare;virtual technology;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: Collaborate2Lose: Collaborating with romantic and non-romantic support persons to improve long-term weight loss

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Pain is a pervasive condition that affects millions of people worldwide. Spinal projection neurons in the superficial laminae of the dorsal horn transmit the ascending pain signal from the spinal cord into the brain; however, the circuitry and functions of output neurons remain incompletely understood. In this proposal, I will characterize the anatomy, functional response properties, and behavioral role of spinal projection neurons to examine their specific roles in nociception.

PI_NAMEs: BLEIMEISTER, ISABEL  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Affective;Anatomy;Behavior;Behavior monitoring;Behavioral;Behavioral Assay;behavioral response;Bilateral;Biological Assay;Brain;Calcium;career;Cell Nucleus;cell type;cellular targeting;chronic pain;Clinical;clinical research site;Contralateral;Data;designer receptors exclusively activated by designer drugs;detector;Development;dorsal horn;efficacy evaluation;experimental study;Future;Genetic;genetic manipulation;Goals;Image;improved outcome;Intervention;Ipsilateral;Knowledge;Laser Scanning Confocal Microscopy;Mediating;Mentors;midbrain central gray substance;Modeling;neural circuit;neuronal patterning;Neurons;neurotransmission;new therapeutic target;Nociception;novel;Optics;Output;Pain;Pain management;pain signal;parabrachial nucleus;Pathway interactions;Patient-Focused Outcomes;Pattern;Persons;Physicians;Play;Population;Preparation;Property;Quality of life;Research Personnel;response;Role;Scientist;Side;Signal Transduction;somatosensory;Spinal;Spinal Cord;Stimulus;Structure;Technical Expertise;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;tool;Training;transmission process;two-photon;Viral;virtual

PROJECT_TITLE: Understanding the functional anatomy of nociceptive spinal output neurons


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Cardiovascular;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: Project Narrative Hispanic/Latino/a persons with multiple sclerosis (H-pwMS) have worse disease trajectories and outcomes and increased mortality compared to their non-Hispanic counterparts. This project seeks to understand what and how healthcare related social determinants of health and medical comorbidities impact critical MS-related outcomes, namely accelerated brain aging and disability, in adult H-pwMS. Such knowledge will lay the foundation for culturally sensitive interventions and healthcare policy changes.

PI_NAMEs: ROMÁN, CRISTINA A. F. (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Acceleration;Adult;Age;age related changes;aging brain;Applications Grants;barrier to care;Biological Markers;Brain;brain health;Brain imaging;brain volume;cardiovascular risk factor;Cardiovascular system;career;Chronology;Clinical;Communities;comorbidity;complement C2a;Data;Dementia;design;Development;disability;Disability Evaluation;Disease;Disease Progression;Disparity;Doctor of Philosophy;Early Intervention;Ensure;Equitable healthcare;ethnic diversity;experience;Foundations;functional outcomes;Goals;health care availability;health disparity;health management;Health Policy;Healthcare;Healthcare Systems;high risk;Hispanic;Hispanic Populations;improve minority health;Individual;Infrastructure;Intervention;Investigation;Knowledge;Latino;Lived experience;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Maintenance;Manuscripts;Measures;Medical;Mentorship;Methods;Minority Groups;Mission;Modeling;mortality;Multiple Sclerosis;multiple sclerosis patient;National Institute on Minority Health and Health Disparities;Nerve Degeneration;Nervous System Disorder;Neurologic;Neuropsychology;Not Hispanic or Latino;offspring;Outcome;Participant;Persons;Population;Populations at Risk;premature;Prognosis;Psychologist;psychosocial stressors;racial diversity;recruit;Reduce health disparities;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;skills;social health determinants;Societal Factors;Societies;Spanish;stem;Stress;Training;Universities;virtual;Work;Writing

PROJECT_TITLE: Barriers to Healthcare and Cardiovascular Risk Influences on Accelerated Brain Aging and Disability in Hispanic Persons with Multiple Sclerosis


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: This study examines two novel ways to improve functioning and recovery among Veterans with serious mental illness (SMI). It will assess the effectiveness of established psychosocial interventions based on cognitive- behavioral therapy (CBT) and stand-alone social skills training (SST) when delivered by Peer Specialists— Veterans with SMI trained to use their own experience and recovery to help other Veterans with SMI. The project will compare outcomes of Veterans with SMI receiving one of three treatments: Cognitive Behavioral Social Skills Training-Peer (CBSST-Peer), stand-alone Social Skills Training-Peer (SST-Peer), or a peer-led, manualized goal setting group. This work is responsive to national calls for Veterans with SMI to receive support that is evidence-based, improves functioning (not just symptoms), and is tailored to individual needs. If successful, CBSST or SST could be adopted by the 1100 Peer Specialists working in VA, greatly increasing the delivery of evidence-based services to these Veterans.

PI_NAMEs: CHINMAN, MATTHEW  (contact);GRANHOLM, ERIC L

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;Advocate;arm;Attitude;Audiotape;Behavioral;Caring;Categories;Clinical;Code;Cognitive;cognitive skill;cognitive testing;Cognitive Therapy;Collaborations;Communication;cost;Data;Education;Educational Curriculum;Educational process of instructing;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness trial;evidence base;experience;Focus Groups;follow-up;Foundations;functional improvement;Future;future implementation;Goals;Healthcare;Healthcare Systems;Homelessness;hospital bed;Hour;Hybrids;Impairment;implementation barriers;implementation determinants;implementation evaluation;implementation facilitators;improved;improved outcome;Independent Living;Individual;innovation;Intercept;Intervention;Interview;Knowledge;Letters;Licensing;Manuals;Measures;Medical center;Mental Health;Methods;novel;Outcome;Outcome Study;Participant;Patient-Focused Outcomes;Patients;peer;peer support;Perception;Persons;Pharmaceutical Preparations;post intervention;primary outcome;programs;psychosocial;psychosocial rehabilitation;Quality of life;Randomized;Recovery;recruit;Rehabilitation therapy;Research;response;Role;Sampling;Schizophrenia;Services;severe mental illness;Severities;Site;skills;skills training;social communication;Social Functioning;social skills;Socialization;Specialist;standard care;standardize measure;Strategic Planning;Structure;Supervision;Surveys;Symptoms;Techniques;Testing;Text;theories;Thinking;Time;Training;treatment arm;treatment effect;Update;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills Training


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Post 9/11 Veterans who enroll in VA health care frequently present with suicidal ideation and/or recent suicidal behavior. Most of these Veterans are not screened that day, and their risk goes undetected. Studies show that screening for suicide risk, and associated mental health factors, can lead to early detection and referral to effective treatment thereby decreasing suicide risk. Many studies also show that technology can improve screening efforts. Building off 7 years of prior work, in this trial we will evaluate an innovative VHA technology, eScreening, to improve rate and speed of suicide risk screening and referral to mental health care compared to current screening methods used by transition care managers. This study will also evaluate a strategy designed to help programs implement eScreening in new sites. The results of the study could help identify best practices for screening in suicide prevention for Post-9/11Veterans enrolling in VHA and provide information on how best to implement technology-based screening into clinical care programs.

PI_NAMEs: PITTMAN, JAMES  (contact)

PROJECT_TERMS: Address;Adoption;alcohol use disorder;Alcohols;Area;Caring;Case Manager;Clinical;clinical care;comparative;Computer software;cost;Data;Depressive disorder;design;Detection;Diagnosis;Diffusion;Documentation;Early Diagnosis;Early identification;Educational workshop;effective therapy;Effectiveness;effectiveness evaluation;effectiveness research;Electronics;Enrollment;Evaluation;Evidence based practice;Feedback;Feeling suicidal;Goals;Health;Health system;Healthcare;Homogeneously Staining Region;Hybrids;implementation efforts;implementation research;implementation science;implementation strategy;improved;innovation;Intervention;Interview;Maintenance;Managed Care;Managed Care Programs;Manuals;Medical Records;Mental Depression;Mental disorders;Mental Health;Mental Health Associations;Mental Health Services;Methodology;Methods;military veteran;Names;Online Systems;Outcome;Paper;Patients;Performance;Phase;Pilot Projects;Positioning Attribute;post 9/11;post intervention;Post-Traumatic Stress Disorders;Practical Robust Implementation and Sustainability Model;pragmatic trial;Process;process improvement;programs;Questionnaires;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;research to practice;response;Risk;scale up;screening;screening program;Site;Speed;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptoms;System;Technology;Testing;Time;Training;user centered design;verbal;Veterans;web-based assessment;Work

PROJECT_TITLE: Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Not Required

PI_NAMEs: POGODA, TERRI K. (contact)

PROJECT_TERMS: disability payment;Post-Traumatic Stress Disorders;Services;Veterans;Work

PROJECT_TITLE: Does Protecting Service-Connected Disability Income Motivate Return to Work in Veterans with TBI and PTSD?

STUDY_SECTION_NAME: Innovation Initiative 2[HSN2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Social behavior deficits are common features of myriad psychiatric illnesses known to have roots in early development, including autism, schizophrenia and anxiety. Yet, there is little understanding of the ontogeny of social behavior in typically developing individuals. The proposedstudies are aimed towards dissecting the neural circuitry supporting flexible social behavior in typical and perturbed development.

PI_NAMEs: OPENDAK, MAYA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adaptive Behaviors;Adult;Age;age related;Amygdaloid structure;Animals;Anxiety;Area;autism spectrum disorder;Award;Behavior;behavior test;Behavioral;behavioral response;Brain;career;career development;Complex;Coupling;Data;Development;Development Plans;developmental neurobiology;dopaminergic neuron;effective therapy;Electrophysiology (science);ex vivo imaging;Exhibits;Fiber;flexibility;Food;Foundations;Frequencies;Goals;Growth;Imaging Techniques;Individual;Infant;Infant Behavior;innovation;insertion/deletion mutation;Laboratory Research;Lead;Life;Literature;Measures;Mental disorders;Mentors;Methodology;nerve supply;neural;neural circuit;neural network;neurobehavioral;Neurobiology;neurodevelopment;Neuronal Plasticity;neurophysiology;Neurophysiology - biologic function;Optics;optogenetics;Partner in relationship;Pathology;peer;pharmacologic;Phase;Photometry;postnatal;prevent;pup;Rattus;receptor;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Rodent;Role;Schizophrenia;skills;social;Social Behavior;Social Behavior Disorders;social bias;Social Development;Social Interaction;spatiotemporal;Stress;System;Techniques;Testing;Time;tool;Training;Trauma;Ventral Tegmental Area;Weaning;Work

PROJECT_TITLE: Neurobiology of Social Behavior: Circuit Analysis in Early Life

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS