NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative α-Synucleine aggregates into ﬁbrils in many neurodegenerative diseases such as Lewy body dementias (LBDs), multiple system atrophy (MSA), and Parkinson’s disease (PD). Understanding the molecular structure and dynamics of both the structured and unstructured parts of α-synuclein ﬁbrils will facilitate the development of new approaches to diagnose and treat these diseases.

PI_NAMEs: SIEMER, ANSGAR B (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Affinity;alpha synuclein;Alzheimer's disease related dementia;Amyloid;Amyloid Fibrils;Binding;Binding Sites;Biological Assay;Biological Markers;C-terminal;Cells;Chimera organism;Complex;Cryoelectron Microscopy;cytotoxicity;Data;Development;Diagnosis;Disease;Goals;Huntington gene;Learning;Lewy Bodies;Lewy Body Dementia;Link;Modeling;Molecular Chaperones;Molecular Conformation;molecular dynamics;molecular modeling;Molecular Structure;monomer;Multiple System Atrophy;Neurodegenerative Disorders;novel strategies;Parkinson Disease;Phosphorylation;Polymorph;Predisposition;Proteins;proteostasis;Research;Residual state;Resolution;solid state nuclear magnetic resonance;specific biomarkers;Structure;Surface;synucleinopathy;Testing;Therapeutic;Time;Toxic effect

PROJECT_TITLE: Intrinsically disordered domains of α-synuclein: effect of fibril formation and fibril polymorphs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-H (02)]


ADMINISTERING_IC: OH

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The 4th International Symposium to Advance Total Worker Health® will have a high public heath impact by meeting the national and international needs for increasing research and practice in Total Worker Health (TWH). We will meet this objective by hosting a TWH education planning workshop in the first project year to identify gaps and opportunities for TWH training and to inform the themes of the Symposium. Our primary objectives are to convene stakeholders across academia, industry, labor, and government to explore research and case studies in TWH, to establish partnerships and collaborations that advance TWH, and to build capacity by providing the necessary knowledge and skills to professionals, employers, workers, policymakers, community groups, and students.

PI_NAMEs: TENNEY, LILIANA  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Growing evidence suggests the cognitive symptoms underlying many psychiatric diseases, including substance use disorder, result from disruption to cue-reward memory. This project will reveal the function of 5 critical amygdala output pathways in cue-reward learning and decision making and, in so doing, reveal a circuit motif for cue-reward memory that will enable both basic and clinical advance.

PI_NAMEs: WASSUM, KATE M (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Amygdaloid structure;Association Learning;Behavior assessment;Brain;Brain region;Clinical;Cognitive;Corpus striatum structure;Coupled;Cues;Data;Decision Making;Desire for food;Dissection;Emotional;Environment;Event;expectation;Exposure to;Failure;Fiber;flexibility;Functional disorder;Funding;Future;Goals;innovation;Knowledge;Lateral;Learning;Maps;Medial;Mediating;Memory;memory encoding;memory process;Mental disorders;Modeling;Modernization;Monitor;Neurobehavioral Manifestations;neuronal circuitry;Neurons;Neurosciences;Nucleus Accumbens;optogenetics;Outcome;Output;Pathway interactions;Pattern;Photometry;Predictive Value;prospective;Psyche structure;Rewards;Stimulus;Substance Use Disorder;System;Testing;tool;Work

PROJECT_TITLE: Amygdala Output Circuitry in Reward Encoding, Expectation, and Decision Making

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Nutrition;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: We proposed a novel therapeutic treatment for diabetic retinopathy, a leading cause of vision loss in working adults. Our strategy uses direct ocular delivery of a new class of drugs that activate nuclear receptors present in most cells of the retina called Retinoid X Receptor (RXR) agonists. We will test if RXR agonists can delay or reverse diabetes-induced retinal damage and investigate the mechanism of RXR-based therapy at cellular and molecular levels.

PI_NAMEs: GORBATYUK, MARINA  (contact);GRANT, MARIA BARTOLOMEO;XU, QINGGUO

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;Agonist;Apoptosis;Area;bench to bedside;Binding;Biochemistry;Biological;Blindness;Blood capillaries;blood glucose regulation;Blood Vessels;Bone Marrow;Cell Culture Techniques;cell type;Cells;Cellular biology;Chronic;Complex;cytokine;db/db mouse;Defect;design;diabetes management;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Dose;Drug Delivery Systems;drug discovery;Drug Kinetics;Dyslipidemias;Elements;Encapsulated;Extravasation;Eyedrops;Fat-Restricted Diet;Fenofibrate;Formulation;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Glucose;Hepatomegaly;High Fat Diet;Human;Hyperglycemia;Hypertriglyceridemia;Hypothyroidism;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;innovation;interest;intravitreal injection;Lead;Leukostasis;lipid biosynthesis;lipid metabolism;lipidome;Lipids;Liver X Receptor;Mediating;Metabolism;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;neurovascular;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel drug class;novel therapeutics;Nuclear;Nuclear Receptors;Oral;Oral Administration;Outcome;particle;Particle Size;particle therapy;Pathogenesis;Pathologic;Pathology;Patients;Penetration;permissiveness;Pharmaceutical Preparations;Physiological;Play;prevent;Prevention;programs;receptor;Receptor Activation;receptor expression;Reducing Agents;repaired;Repression;Retina;retinal damage;Role;RXR;Safety;small molecule;Streptozocin;Structure of retinal pigment epithelium;systemic inflammatory response;targeted delivery;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;Transactivation;transcription factor;transcriptomics;Translational Research;Vascular Endothelium;Weight Gain

PROJECT_TITLE: RXR-based therapy for diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Nearly 70% of U.S. adults who smoke cigarettes want to stop smoking, but only 7.5% manage to maintain abstinence. Craving and negative emotions are major factors in lapses in abstinence. This application proposes to examine a novel and simple approach that can target both factors.

PI_NAMEs: TABIBNIA, GOLNAZ  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;addiction;Adult;Affect;Affective;Amygdaloid structure;Anterior;Arousal;Brain region;Cause of Death;Cessation of life;Cigarette;cigarette craving;cigarette smoke;cingulate cortex;Clinical;Clinical Trials;Cognitive;cognitive function;cognitive reserve;coping;Corpus striatum structure;craving;Cues;Data;Data Set;distraction;Distress;efficacy testing;emerging adult;emotion regulation;Emotional;emotional experience;Emotions;experience;Exposure to;Feeling;Fright;Functional Magnetic Resonance Imaging;Goals;Informal Social Control;Insula of Reil;Intervention;Label;Link;Los Angeles;man;Mediating;Methods;Names;negative affect;neural;neural correlate;Neural Pathways;neuromechanism;novel;Outcome;Participant;Patient Self-Report;Persons;Phobias;Prefrontal Cortex;prevent;psychologic;Recommendation;Regulation;Relapse;response;Rest;Rewards;Smoke;Smoking;smoking abstinence;smoking cessation;Stimulus;substance use;Substance Use Disorder;Techniques;Testing;Time;Tobacco smoking behavior;tool;verbal;Withdrawal;Woman;Work;Writing

PROJECT_TITLE: "Cue Labeling as a Tool to Regulate Craving During Abstinence from Smoking”.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (J1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Recent human neuroimaging studies have revealed systematic differences in how the brain represents perceptual experience versus memories of perceptual experience. In the proposed research, we will use innovative neuroimaging approaches to understand how the human brain transforms perceptual experience into memories. The research will provide fundamental insight into the nature of human memory and underlying neural mechanisms.

PI_NAMEs: KUHL, BRICE ALAN (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Algorithms;analytical method;Animal Model;Area;Basic Science;Behavior;behavior prediction;Behavioral;Brain;Brain region;cognitive neuroscience;Episodic memory;Event;Exhibits;experience;Functional Magnetic Resonance Imaging;Future;Goals;Health;Human;Human Characteristics;image processing;innovation;insight;Learning;Link;Maintenance;Measures;member;Memory;Methodology;Methods;model generalizability;Modeling;Natural Language Processing;neural;neuroimaging;neuromechanism;Noise;novel strategies;Outcome;Parietal;Parietal Lobe;Pattern;Perception;programs;Research;Sensory;sensory cortex;Short-Term Memory;simulation;spatial memory;Techniques;Testing;tool;Transcend;verbal

PROJECT_TITLE: Neural Transformations Linking Perception and Memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Maternal cardiovascular and hemodynamic adaptations during pregnancy are critical for accommodation of the developing embryo and fetus. Insufficient changes in cardiovascular function can lead to numerous pregnancy complications and represent a major risk for maternal and fetal health. We aim to develop a dynamical model of cardiovascular function in pregnancy that will serve as a tool to aid understanding of cardiovascular maladaptations in pregnancy and guide personalized therapeutic interventions.

PI_NAMEs: MYATT, LESLIE  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: anti-cancer research;Arthritis;Assessment tool;Autoimmune Diseases;Behavior;behavior prediction;Biomechanics;Blood flow;blood flow measurement;Blood Vessels;Calibration;cancer type;Cardiovascular Abnormalities;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular Physiology;Cardiovascular system;Characteristics;Data;Development;Diabetes Mellitus;Differential Equation;Disease;Doppler Ultrasound;Education;embryo/fetus;Equation;experimental study;fetal;Fetal health;Fetus;flexibility;Formulation;Future;genetic makeup;Growth and Development function;Hematological Disease;hemodynamics;Hypertension;hypertensive;in silico;Individual;innovation;insight;Intervention;Investigation;Kidney;Knowledge;Letters;Liquid substance;Magnetic Resonance Imaging;Maternal Health;maternal risk;mathematical model;Mathematical Model Simulation;Mathematics;Metabolic Diseases;model building;Modeling;Modification;Neurodegenerative Disorders;new therapeutic target;Normal Range;Nutrient;Organ;Outcome;Oxygen;Patients;Pattern;personalized medicine;personalized therapeutic;Phenotype;physiologic model;Physiological;Placenta;Placentation;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy hypertension;Publications;Regulation;response;Risk Assessment;Risk Factors;Role;sex;simulation;Statistical Models;Stroke;Surveys;synergism;System;Testing;Therapeutic Intervention;therapeutic target;Time;tool;tool development;treatment effect;ultrasound blood flow measurement;Uterus;Validation;virtual patient;Work

PROJECT_TITLE: Modeling cardiovascular function in pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science

ORG_CITY: WASHINGTON

ORG_NAME: GERONTOLOGICAL SOCIETY OF AMERICA

ORG_STATE: DC

PHR: PROJECT NARRATIVE The Biology of Aging program at the Gerontological Society of America (GSA) 2024 Seattle meeting is organized in accordance with the GSA’s mission to promote interactions between biologists and other scientists of diverse disciplines focused on aging, age-related disease and disability; and the social, psychological, and public policy impacts of an aging society. The goals of the Biology of Aging program are to (1) present cutting-edge advances in biology of aging research that provide new avenues for translation to human well-being and extension of healthy human lifespan and (2) to expand the diversity of scientists actively participating in biology of aging research. Our program shows that 31% of our speakers are early-stage investigators, 42% are women, and 29% are from underrepresented minority groups.

PI_NAMEs: D'ANTONIO, PATRICIA M (contact);LEBRASSEUR, NATHAN K

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;age-related disease;Aging;aging mechanism;aging related;aging related disease;American;Applications Grants;Award;behavioral and social science;Biological;Biological Aging;Biological Sciences;Biology;Biology of Aging;career;Cities;clinical care;Collaborations;Communication;Communities;Data;Dedications;disability;Discipline;Education;Educational workshop;Elderly;Ensure;Equilibrium;Evaluation;experience;Exposure to;Faculty;Feedback;Female;Funding;Gender;Geography;Geriatrics;Gerontology;Goals;Grant;hallmarks of aging;Health;Health Professional;Health Sciences;Hearing;high standard;Human;improved;innovation;interest;Intervention;Leadership;life span;Medical;meetings;member;Mentorship;Minority;Minority Groups;Mission;Modeling;National Institute on Aging;novel;Oral;parity;Personal Satisfaction;Policies;Postdoctoral Fellow;posters;programs;psychologic;psychological aspect of aging;Psychologist;Public Health;Public Policy;Recording of previous events;recruit;Request for Proposals;Research;Research Personnel;Respondent;Schedule;Science;Scientific Advances and Accomplishments;Scientific Societies;Scientist;Series;social;Social Sciences;Societies;sociologist;Sociology;student participation;Students;success;symposium;Talents;translation to humans;translational applications;translational goal;translational potential;Travel;Underrepresented Minority;Underrepresented Populations;virtual;Woman;Work

PROJECT_TITLE: Biological Science Program at The Gerontological Society of America's 2024 Annual Scientific Meeting

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: CE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Despite the known association between the quality of participant relational engagement with service providers and clinical outcomes, limited studies have examined caregiver Relational Responsiveness (RR) as a mechanism to achieve maltreatment prevention program outcomes. Using a realist-informed mixed method approach, this study will examine RR’s role in mediating the effects of a community-based maltreatment prevention program, the Family Success Network (FSN) on protective factors against maltreatment and the contexts within which RR’s mediation effects are activated or inhibited. This study will advance the Healthy People 2030 priority area of injury and violence prevention by building the base for the science of caregiver engagement in maltreatment prevention programs and thereby advancing the knowledge of innovative strategies for the prevention of violence.

PI_NAMEs: MOON, DEBORAH J. (contact)

PROJECT_TITLE: CE23-003 - Caregiver Relational Responsiveness (RR): An Understudied Fidelity Construct as a Mechanism to Increase Protective Factors Against Maltreatment.


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative - Overall The Cincinnati Rheumatic Diseases Resource Center will promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children. This will be done by coordinating resources and core services as well as promoting interdivisional, interdepartmental, and national collaborations.

PI_NAMEs: KOTTYAN, LEAH CLAIRE (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Adult;Animal Model;Area;Autoimmune;Autoimmune Diseases;Autoimmunity;autoinflammation;Basic Science;Bioinformatics;Biological;Biomedical Research;career;Caring;Categories;Cells;Cellular biology;Center Core Grants;Child;Childhood;Chronic Childhood Arthritis;Clinical;Clinical Trials;Collaborations;Communities;comorbidity;cost;data submission;Development;Diagnosis;Disease;Doctor of Philosophy;Education;Educational workshop;Equipment;Etiology;expectation;Faculty;falls;Fostering;Functional disorder;functional genomics;Funding;Funding Opportunities;Genetic;Genomics;Goals;Grant;Growth;Health;Immune;Immunobiology;improved;Individual;Inflammation;Inflammatory;Infrastructure;innovation;insight;Institution;interdisciplinary approach;interdisciplinary collaboration;International;Investigation;Investments;Knowledge;Laboratories;Laboratory Finding;lectures;Medical;Medical center;Medical Research;Medicine;member;Methods;Modeling;Molecular Biology;Morbidity - disease rate;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathology;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;pediatric rheumatic diseases;Phenotype;Pilot Projects;prevent;Process;programs;Protocols documentation;recruit;Research;Research Infrastructure;Research Personnel;Resources;Rheumatism;Rheumatology;Scholars Program;Services;Societies;symposium;Systemic Lupus Erythematosus;Techniques;Technology;Tissue Banks;tool;Translating;Translational Research;translational study;Underrepresented Populations;United States National Institutes of Health;visiting scholar;Work


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PROJECT_TERMS: Advisory Committees;Autoimmune Diseases;Autoimmune Process;Autoimmunity;Childhood;Clinic;Communities;Complement;cost;design;Doctor of Medicine;Doctor of Philosophy;Documentation;Education;Evaluation;Expenditure;experience;Faculty;Fellowship;Financial Support;Funding;Goals;Grant;Health;Human Resources;Individual;Inflammation;innovation;Institution;Leadership;Learning;lectures;Medical Research;member;Monitor;new technology;novel;Office of Administrative Management;operation;organizational structure;pediatric rheumatic diseases;Physician Executives;Physicians;Preparation;programs;Progress Reports;Research;Research Personnel;Research Support;Resources;Rheumatism;rheumatologist;Rheumatology;Scholars Program;Series;Services;Strategic Planning;Structure;success;synergism;Technology;Testing;Thinking;Training;Training Programs;Travel;visiting scholar;Work

PROJECT_TITLE: Admin Core


PI_NAMEs: SCHULERT, GRANT SANFORD (contact)

PROJECT_TERMS: Acceleration;Advanced Development;Aliquot;Arthritis;biobank;Biological;Biological Markers;Biopsy;Bone Marrow;Bronchoalveolar Lavage;career;Cells;Child;Childhood;Chromatin;Collection;Communities;cost;Cost Savings;Coupled;Data;Data Mart;design;Development;Disease;DNA;Ensure;Epigenetic Process;experience;family burden;flexibility;Fostering;functional genomics;Funding;Future;Genetic study;Genomic approach;Goals;Health;Human Resources;Immunologics;improved;Individual;Industry;Infrastructure;infrastructure development;innovation;Institution;investigator-initiated translational research;kidney biopsy;Laboratories;Leadership;Liquid substance;Longevity;Longitudinal Studies;Mononuclear;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;North America;novel therapeutics;Onset of illness;Patients;pediatric rheumatic diseases;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Prevention;Procedures;Process;Proteins;protocol development;Registries;Replacement Arthroplasty;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rheumatism;Rheumatology;RNA;sample collection;Sampling;Scientist;Secure;Serum;single cell analysis;Site;Specimen;Strategic Planning;Structure;Structure of parenchyma of lung;Synovial Fluid;System;Time;Tissue Banks;Tissue Sample;Tissues;Training;Translational Research;ultrasound;United States;Urine;Whole Blood

PROJECT_TITLE: Tissue Repository Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WEIRAUCH, MATTHEW TYSON (contact)

PROJECT_TERMS: Address;Affect;Allergic Disease;American;analysis pipeline;ATAC-seq;Autoimmune;base;Binding;Bioinformatics;bioinformatics pipeline;Biological Assay;Biomedical Research;Blood;Cells;ChIP-seq;Chromatin;Chromatin Loop;Code;Collaborations;Collection;Communities;Complex;Computational Technique;Computer software;computerized tools;Consult;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Data Analytics;data centers;data integration;data management;data repository;Data Set;Data Storage and Retrieval;Databases;deep learning;Deposition;design;diagnostic strategy;Disease;DNA;Emerging Technologies;Epigenetic Process;experience;Experimental Designs;experimental study;Flow Cytometry;Functional disorder;functional genomics;Gene Expression;Gene Expression Regulation;Genetic;genetic variant;genome sequencing;genomic data;Genomics;Genotype;Goals;high dimensionality;Immunologist;Immunophenotyping;Inflammatory;Informatics;innovation;insight;Institution;Knowledge;large datasets;Longitudinal Studies;Measures;Medical;Medical center;member;Metadata;metadata standards;Methodology;Methods;Modeling;Modernization;Molecular;Molecular Disease;multidimensional data;novel;Nucleic Acid Binding;Pediatric Hospitals;Phenotype;polygenic risk score;Prevention strategy;Process;Proteins;Proteomics;public database;Publishing;Quality Control;Records;Reproducibility;Research;Research Personnel;Research Support;Resources;Rheumatism;RNA;RNA Sequences;RNA-Binding Proteins;Sampling;Services;single-cell RNA sequencing;System;Therapeutic;Tissue Banks;Tissue Sample;Tissue-Specific Gene Expression;tool;transcription factor;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;variant of interest;virtual;whole genome;wiki

PROJECT_TITLE: Bioinformatics and Modeling Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome

PROJECT_TERMS: Acceleration;Affinity;Alleles;Animal Model;ATAC-seq;Autoimmune;autoinflammatory;Automobile Driving;base;Binding;Biological Assay;Biological Process;Board Certification;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Loop;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical assessments;Clinical Management;Collaborations;Communities;Complex;Consultations;cost;deep sequencing;Development;Disease;disease model;DNA;DNA Sequence;DNA sequencing;Doctor of Philosophy;Electrophoretic Mobility Shift Assay;Enhancers;Epidemiology;Etiology;experimental study;Family;functional genomics;Genes;Genetic;genetic association;genetic regulatory protein;Genetic Risk;Genetic study;Genetic Transcription;genetic variant;genome-wide;Genomic approach;genomic data;Genomics;Genotype;histone modification;Histones;Immune;Immune System Diseases;Immunoprecipitation;Individual;Inflammatory;Infrastructure;innovation;insight;Investigation;Libraries;Luciferases;Measures;Medical center;Molecular;Molecular Biology;molecular diagnostics;novel therapeutic intervention;Pathogenesis;Pathologist;Pathology;Patients;Pediatric Hospitals;pediatric rheumatic diseases;Peer Review;Phenotype;Physicians;Plasmids;polygenic risk score;Population;Precipitation;Preparation;Productivity;promoter;Proteins;Protocols documentation;Publications;Reagent;Regulation;Reporter;Research;Research Design;Research Personnel;Research Project Grants;Resources;Rheumatism;risk variant;RNA;Role;Scientist;screening;Services;single-cell RNA sequencing;System;Technical Expertise;Technology;Time;tissue preparation;Tissue Sample;Tissues;tool;transcriptome sequencing;transcriptomics;Transfection;Translations

PROJECT_TITLE: Functional Genomics Core


PI_NAMEs: THORNTON, SHERRY L (contact)

PROJECT_TERMS: Address;antigen-specific T cells;Apoptosis;Area;Arthritis;Autoimmune Diseases;Autoimmune Process;autoimmune rheumatologic disease;autoinflammatory;autoinflammatory diseases;Bioinformatics;Biological;Biology;Calibration;Cell Cycle;Cell Proliferation;Cell Separation;Cell surface;cell type;Cells;Cellular biology;Child;Childhood;Chronic Childhood Arthritis;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;cost;Data;Data Analyses;data cleaning;data management;Data Storage and Retrieval;Dendritic Cells;design;Detection;Development;Disease;Equipment;Experimental Designs;Flow Cytometry;Functional disorder;functional genomics;Gene Expression;Gene Expression Profiling;Genetic Transcription;genome editing;Goals;Health Services Accessibility;high dimensionality;Human Resources;Image Cytometry;Immune;Immune response;Immune system;Immunologics;Immunophenotyping;Individual;Inflammation Mediators;Inflammatory;instrument;Joints;Juvenile Dermatomyositis;Lasers;Lymphocyte;Macrophage;Maintenance;Methodology;Modeling;monocyte;novel;novel therapeutic intervention;Pathologic;Pathway interactions;pediatric rheumatic diseases;Phenotype;Ploidies;Population;Procedures;Process;Protein Secretion;Proteins;Proteomics;Quality Control;release of sequestered calcium ion into cytoplasm;Reporter;Reproducibility;Research;Research Personnel;Resources;Rheumatism;Rheumatoid Arthritis;Rheumatology;RNA;Sampling;Services;Signal Transduction;single cell analysis;single cell genomics;single cell proteins;Sorting;Stains;Synovial Fluid;Systemic Lupus Erythematosus;Technical Expertise;Techniques;Technology;Tissues;Training;transcriptome sequencing;transcriptomics;voltage

PROJECT_TITLE: Integrative Cell Phenotyping Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Viral reservoir cells persist despite suppressive antiretroviral therapy and represent the major barrier to a cure of HIV-1 infection. This application focuses on a multidimensional longitudinal analysis of viral reservoir cells in blood and tissues, using novel next-generation sequencing and histologic analysis techniques.

PI_NAMEs: ESTES, JACOB D;LICHTERFELD, MATHIAS  (contact);VANDEKERCKHOVE, LINOS

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;acute infection;Anatomy;antiretroviral therapy;Autologous;Behavior;Biological Assay;biophysical properties;Blood;CCR5 gene;CD4 Positive T Lymphocytes;Cell Physiology;Cell Proliferation;Cells;Cellular Assay;Chromatin;chromosomal location;Clinical;Clone Cells;cohort;design;Development;Diagnosis;Dimensions;Disease;Disease remission;DNA;DNA Methylation;Environment;Epigenetic Process;Evaluation;Evolution;Future;Gene Expression Profile;genetic pedigree;Genetic Transcription;Genome;genome analysis;Genomic DNA;Heterogeneity;Histologic;histone modification;HIV;HIV-1;Human;Image;Immune;Immune response;Immunologics;Individual;Infection;integration site;Interruption;Intervention;Lead;Location;longitudinal analysis;Lymphoid Tissue;Mediating;Medical;Microanatomy;Molecular;Monitor;next generation sequencing;novel;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physiology;Population;Positioning Attribute;Predisposition;Process;Proliferating;prospective;Proviruses;Reporting;Residual state;Resistance;RNA;Sampling;Selection for Treatments;Shapes;Shock;Signal Transduction;Stem cell transplant;Stimulus;Structure;Surface;Techniques;Technology;Testing;therapeutic target;Time;Tissue Sample;Tissues;Viral;Viral Genes;viral rebound;Viral reservoir;Viremia;Work

PROJECT_TITLE: Selection and Evolution of HIV-1 reservoir cells in blood and tissues

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Asthma is the third leading cause for hospitalization in children and the leading cause of school absenteeism in the United States and minority children living in low-income communities have an increased burden of asthma. Effective interventions require a multi-level approach and successful implementation requires engaging community stakeholders to develop sustainable systems of care that reach high-risk children where “they live, learn, and play”. Asthma CHAMPS will implement a school- based multi-level intervention that has high potential to reduce asthma morbidity among Baltimore City children and to serve as a model approach that can be adapted to similar urban centers to eliminate asthma disparities.

PI_NAMEs: EAKIN, MICHELLE NUTTALL (contact);MCCORMACK, MEREDITH C

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Absenteeism;Administrator;Adoption;Adrenal Cortex Hormones;Advisory Committees;Asthma;asthma inhaler;Baltimore;care systems;Caring;Child;Childhood;Cities;Collaborations;Communities;community engagement;Community Health Aides;Community Healthcare;community intervention;community setting;Control Groups;design;Directly Observed Therapy;Disparity;Education;effective intervention;Effectiveness;effectiveness evaluation;elementary school;Emergency department visit;Enrollment;Ensure;evidence base;Family;Feedback;Foundations;Goals;Health;health care service utilization;health disparity;Health Personnel;high risk;Home;Hospitalization;Human Resources;implementation evaluation;implementation strategy;improved;Intervention;intervention mapping;intervention program;Interview;Knowledge;Learning;Link;literacy;Location;Low income;Medicaid;Medical;member;minority children;Modeling;Morbidity - disease rate;multidisciplinary;Needs Assessment;Oral;organizational readiness;Outcome;Parents;pediatrician;Penetration;Pharmaceutical Preparations;Phase;Play;Policies;Population;pragmatic trial;Prevalence;programs;Qualitative Methods;Recommendation;Recording of previous events;Risk;satisfaction;school health;Schools;Self Management;Structure;success;successful intervention;teacher;Trust;United States;urban children;Urban Community;Waiting Lists

PROJECT_TITLE: Implementation of Asthma Community Home and School Management Program (Asthma CHAMPS)


ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Overall PPG Narrative: Molecular mechanisms of filoviral-host interactions Ebola virus and Marburg virus are important emerging pathogens with significant potential to impact global public health. Host-viral interactions contribute to disease course and dictate the impact of infection but are incompletely defined for filoviruses. We will address this gap through a multidisciplinary approach that will identify, validate, and characterize filoviral proteins and associated host factors to shed light on critical interactions that drive viral replication and new therapeutic targets.

PI_NAMEs: AMARASINGHE, GAYA K. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Academia;Actins;Address;Antibodies;Antibody Therapy;Biochemical;Biochemistry;Biological;Biological Assay;Biology;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Computer Assisted;conditional knockout;Containment;Cryoelectron Microscopy;Data;data complexity;data sharing;Development;Disease;Disease Outbreaks;Distant;Ebola virus;Emerging Communicable Diseases;emerging pathogen;Ensure;Evaluation;experience;Family;Family member;Filoviridae Infections;Filovirus;Funding;Genetic;Genetic Transcription;Goals;Growth;human disease;Immune response;Immunology;in vivo;Industry;Infection;innovation;insight;Integration Host Factors;interdisciplinary approach;Knockout Mice;Knowledge;Laboratories;Learning;Maps;Marburg Virus Disease;Marburgvirus;Mass Spectrum Analysis;medical countermeasure;Methods;Modeling;Molecular;mouse model;Mutation;new therapeutic target;novel;novel therapeutic intervention;Nucleocapsid;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;Periodicals;Phenotype;Physical condensation;Play;Predisposition;Productivity;Program Research Project Grants;Progress Reports;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteomics;Public Health;Publications;Reagent;Records;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA Processing;Rodent;Role;Scientist;Set protein;structural biology;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tomography;training opportunity;Transgenic Organisms;Vaccines;Viral;Viral Proteins;Virion;virology;Virus;Virus Assembly;Virus Diseases;Virus Replication;Virus-like particle;Work;Zoonoses

PROJECT_TITLE: Molecular Mechanisms of Filoviral-host Interactions


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

PROJECT_TERMS: Actins;Animal Experiments;Antibodies;Antibody Formation;Applications Grants;Binding;Biochemical;Biochemistry;biodefense;Biological Models;Budgets;Cell Culture Techniques;Cell Line;Cells;Cellular biology;cloud based;Communication;Conflict of Interest;conflict resolution;Containment;Data;data access;data dissemination;data infrastructure;data management;data sharing;Databases;Decision Making;defined contribution;Development;Documentation;Ebola virus;Ensure;Equipment and supply inventories;Evaluation;experimental study;Filoviridae Infections;Filovirus;Genetic Materials;global health;Goals;In Situ;Infection;Information Dissemination;insight;Integration Host Factors;Intellectual Property;Knock-out;Lead;Leadership;Life Cycle Stages;Marburgvirus;meetings;member;Mission;Molecular;Molecular Biology;Monitor;multidisciplinary;Mus;new therapeutic target;novel;Nucleic Acids;Office of Administrative Management;Online Systems;pathogen;Performance;Policies;Preparation;Program Research Project Grants;programs;Progress Reports;protein complex;Proteins;Proteomics;Publications;Reagent;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;RNA Processing;Role;Safety;Scientific Advances and Accomplishments;Scientist;Secure;Set protein;Site;synergism;Teleconferences;Training;training opportunity;Travel;United States National Institutes of Health;Viral;virology;virtual;virus genetics;Virus Replication;web site;website development;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Rare Diseases

PI_NAMEs: LEUNG, DAISY W (contact)

PROJECT_TERMS: A549;Address;Antibodies;antibody engineering;Antibody Formation;Antibody Specificity;Antigens;antiviral drug development;Biochemical;Biological Assay;Case Fatality Rates;Category A pathogen;Cell Culture Techniques;Cell Line;cell type;Cells;Collaborations;Communities;Complex;conditional knockout;Consultations;Deposition;Development;DNA;Ebola;Ebola virus;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;experimental study;Filovirus;flexibility;Funding;Generations;Genes;Genome;Genome engineering;Goals;Hela Cells;Human;Hybridomas;Immune Evasion;Immune system;Immunize;Immunofluorescence Immunologic;Immunoglobulin G;Immunoprecipitation;In Vitro;induced pluripotent stem cell;Infection;Injections;innovation;Integration Host Factors;Knock-out;knockout animal;Knockout Mice;Leadership;Luciferases;Marburgvirus;Methods;Mission;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;National Institute of Allergy and Infectious Disease;nonhuman primate;Pathogenesis;Pathway interactions;Peptide antibodies;Phage Display;Phosphorylation;Polymerase;Positioning Attribute;Post-Translational Protein Processing;protein protein interaction;Proteins;Reagent;Recombinants;Research Project Grants;Resources;Role;Standardization;synthetic antibodies;System;Technology;Transgenic Animals;Vaccines;Validation;Viral;Viral Antibodies;Viral Proteins;Virus;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Antibody and Reagent Development Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: DAVEY, ROBERT A (contact)

PROJECT_TERMS: 129 Mouse;Address;Amino Acids;Animal Disease Models;Antibodies;automated assessment;Behavior;biosafety level 4 facility;Blood;Boston;Buffers;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoelectron Microscopy;design;Disease;disease model;Disease Outcome;disorder control;Ebola virus;Emerging Communicable Diseases;Ensure;Evaluation;Filoviridae Infections;Filovirus;forest;Genetic Complementation Test;Genetic Transcription;Genome;GRP94;Histologic;Human Resources;Image Analysis;Immunoprecipitation;Impact evaluation;in vivo;Infection;Infectious Diseases Research;inhibitor;innovation;insight;Integration Host Factors;Kinetics;knock-down;Knock-out;knockout animal;knockout gene;Knockout Mice;Liver;Marburgvirus;Measures;Methods;microscopic imaging;Microscopy;Modeling;Molecular;Molecular Biology;mouse model;Mouse Strains;Mus;mutant;novel;novel virus;Nucleic Acids;Outcome Measure;overexpression;pathogen;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Process;Production;programs;protein complex;protein expression;protein function;Proteins;Publications;Reagent;recombinant virus;Recombinants;repository;Research Project Grants;Resources;reverse genetics;RNA;Rodent;Role;Science;Severities;Small Interfering RNA;small molecule inhibitor;Source;Stains;stem;Structure;Subcellular structure;success;Sudan;Symptoms;System;targeted treatment;Techniques;Testing;therapy development;Training;Transcriptional Regulation;Transgenic Animals;Transgenic Mice;Transgenic Organisms;trizol;Ubiquitination;Universities;Viral;Viral Antigens;viral detection;Viral load measurement;Viral Proteins;viral RNA;Virion;Virus;Virus Diseases;Western Blotting;Work;X-Ray Crystallography

PROJECT_TITLE: High Biocontainment (BSL4/ABSL4) core for replication competent virus work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

PROJECT_TERMS: Actins;Address;Africa;Anti-viral Agents;Biochemical;Biochemistry;Biology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Complex;Core Protein;COVID-19 pandemic;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Data;Development;Disease;Disease Outbreaks;Ebola virus;enzyme activity;Event;Family;Filovirus;Genetic Transcription;Genome;global health;Health;Human;Hybrids;Immune;Immune response;Infection;innovation;insight;Integration Host Factors;Knowledge;Length;Low-Density Lipoproteins;Marburgvirus;Mass Spectrum Analysis;Methods;Molecular;multidisciplinary;multiple omics;Nature;novel;nuclease;Nucleocapsid;Nucleocapsid Proteins;Nucleoproteins;Open Reading Frames;particle;Pathway interactions;Physical condensation;Play;Polymerase;Positioning Attribute;Post-Translational Protein Processing;Process;Productivity;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteomics;Publications;Publishing;receptor;Regulation;Research Personnel;Research Project Grants;Resolution;Resources;RNA;RNA chemical synthesis;RNA-Directed RNA Polymerase;Roentgen Rays;Role;Signal Transduction;Small Interfering RNA;structural biology;Structure;Therapeutic;therapeutic target;Time;tool;vaccine candidate;Viral;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Biochemical and structural mechanisms at the filoviral-host interface


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

ORG_STATE: MI

PHR: Project Narrative The research in this application will first characterize the delayed and progressive emergence of CTE- and psychiatric-like pathologies in a humanized mouse model of repetitive mild TBI. TBI is a major health problem among Veterans and its negative effects are amplified by numerous co-morbid conditions that are known to follow this injury to include cognitive dysfunction, alterations in vision and sleep and psychiatric conditions. An effective treatment for TBI is not available so we will also test new mechanistic-based therapies to protect against the chronic pathologies associated with TBI. Work in this application is aimed at BLRD and VA ORD research objectives to increase the understanding of chronic injury to the brain with emphasis on the long-term effects of co-occurring conditions, and to test new treatments for these conditions.

PI_NAMEs: ANGOA-PEREZ, MARIANA  (contact);KUHN, DONALD M

PROJECT_TERMS: Ablation;Acetylation;Acute;Afghanistan;Anxiety;Appearance;Astrocytes;Autopsy;Behavior Disorders;Behavioral;behavioral outcome;Brain;Chronic;chronic traumatic encephalopathy;Clinical;Clinical Trials;clinically significant;Cognitive deficits;combat zone;comorbidity;Complex;cost;Craniocerebral Trauma;CSF1R gene;Data;Deacetylation;Development;Disease;effective therapy;Enzymes;Equilibrium;experimental study;Exposure to;Frequencies;Functional disorder;glial activation;Gliosis;Goals;HDAC6 gene;Head;head impact;Health;Healthcare;Histone Deacetylase Inhibitor;Human;humanized mouse;Impaired cognition;Individual;Inflammation;inhibitor;Injury;Iraq;Lead;Long-Term Effects;Macrophage Colony-Stimulating Factor Receptor;Medical;Mental Depression;Mental disorders;Microglia;Microtubules;mild traumatic brain injury;Military Personnel;military service;military veteran;Mission;Modeling;Modification;Motion;mouse model;Mus;Nature;Nerve Degeneration;neuroinflammation;Neurological outcome;Neurons;neuropathology;novel;novel therapeutics;Outcome;outcome forecast;Parkinson Disease;Pathologic;Pathology;Phosphorylation;prevent;Prevention;Publishing;Research;service member;Sleep;Sleep Disorders;Suicide;Symptoms;tau Proteins;tau-1;Tauopathies;TBI treatment;Testing;Therapeutic Intervention;Time;Traumatic Brain Injury;treatment duration;Veterans;virtual;Vision;white matter;Work

PROJECT_TITLE: Delayed and Progressive Emergence of CTE- and Psychiatric-like Pathologies after Repetitive Mild TBI


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: The number of new traumatic brain injury (TBI) cases for U.S. Military forces has more than doubled in the last five years and will continue to grow. TBI increases impulsivity and the risk for suicidality. Moreover, impulsivity is a risk factor for suicide. This proposal is part of a Collaborative Merit Award for TBI application that will investigate the mechanisms by which TBI enhances suicidality in Veterans. This specific application will test the hypothesis that neuroinflammation and degeneration of serotonergic neurons in the raphe nucleus leads to increased impulsivity in an animal model of TBI. This work extends previous results showing that serotonin is important for decision-making and pontine neurons in proximity to serotonergic neurons degenerate after TBI. The predicted results will identify a key mechanism by which TBI enhances impulsivity and suicide risk, allowing for therapeutic targeting to ultimately benefit Veterans quality of life.

PI_NAMEs: BECK, KEVIN D. (contact)

PROJECT_TERMS: Acoustics;Anatomy;Animal Model;Animals;Antiinflammatory Effect;Area;Attenuated;Award;behavior test;Behavioral;Biological Markers;Blood;Brain;Brain Concussion;Brain region;Brain Stem;brain tissue;Cell Nucleus;Chronic;Cognitive;Data;Decision Making;discounting;Drug abuse;Evaluation;Female;fluid percussion injury;Fluoxetine;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gene Expression;Gene Expression Profiling;Human;human imaging;Image;immunoreactivity;Impulsive Behavior;Impulsivity;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Lateral;Lead;Link;Liquid substance;male;Measures;Mental Depression;mild traumatic brain injury;Military Personnel;Modeling;Motor;Nerve Degeneration;neural circuit;Neurobiology;neuroinflammation;Neurons;novel;nucleus reticularis;Pathologic;Percussion;Pontine structure;preference;prevent;Procedures;Process;Quality of life;raphe nuclei;Rattus;Recording of previous events;Research;response;Rewards;Risk Factors;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;Sex Differences;Site;Social isolation;Startle Reaction;Stress;suicidal;suicidal behavior;suicidal risk;Suicide;Symptoms;Synapses;Testing;therapeutic target;Time;trait;Traumatic Brain Injury;Veterans;Work

PROJECT_TITLE: CTBI: Traumatic brain injury-induced inflammation effects on cognitive evaluations and response inhibition: Mechanisms of increased risk for suicidality


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PHR: EASTER Application identifier 1161104 Project Narrative We propose to adapt, apply, and evaluate two emerging technologies: a) artificial intelligence (AI) supported spectroscopic detection of high-risk human papillomavirus (hrHPV) in urine for cervical cancer screening and b) AI supported cervical image interpretation for diagnosis and treatment guidance. Together these will represent a fluent, user-friendly and affordable system for cervical cancer screening, diagnosis and treatment selection (ablation or excision) specifically for low and middle income countries (LMICs). Our team comprising of clinicians experienced in conducting field trials in LMICs, internationally recognized inventors in cervical precancer treatment technologies, biomedical engineers in spectroscopy, AI software developers and molecular biologists will work together on an existing spectroscope and device prototype to deliver a comprehensive AI-based solution to cervical cancer screening and treatment in LMICs.

PI_NAMEs: BASU, PARTHA  (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Ablation;Acetic Acids;algorithm training;Algorithmic Analysis;anti-cancer research;Artificial Intelligence;artificial intelligence algorithm;biobank;Biomedical Engineering;Blood Vessels;Cervical;Cervical Cancer Screening;Cervix Neoplasms;Cervix Uteri;Characteristics;Clinic;Collaborations;college;Colposcopy;Computer Analysis;Computer software;Cost Analysis;cost comparison;Data Collection;Decision Making;Delaware;design;Detection;Devices;Diagnosis;Discipline;Discrimination;Disease;Eligibility Determination;Emerging Technologies;Engineering;ergonomics;Europe;Evaluation;evidence base;Evolution;Excision;experience;Expert Opinion;Expert Systems;Feedback;field study;Health Sciences;Histology;Histopathology;HIV;HPV positive;HPV screening;HPV-High Risk;Human Papillomavirus;Image;Image Analysis;Imaging Device;improved;India;Industry;industry partner;infrared spectroscopy;innovation;International;International Agency for Research on Cancer;Lesion;light emission;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicine;Methods;Modeling;Molecular;mortality;Names;novel;Pattern;Penetration;Performance;Phase;Pilot Projects;point of care;Point of Care Technology;premalignant;prospective;prototype;recruit;Research;Resolution;Sampling;screening;Selection for Treatments;Sensitivity and Specificity;Signal Transduction;spectrograph;spectroscope;Spectrum Analysis;standard of care;Stream;Structure;Support System;System;Techniques;Technology;Testing;Thailand;Training;Triage;Universities;uptake;Urine;user-friendly;Vagina;Validation;vector;Visual;Visualization;Woman;Work;Zimbabwe

PROJECT_TITLE: A novel, one stop, affordable, point of care and artificial intelligence supported system of screening, triage and treatment selection for cervical cancer and precancer in the LMICs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

PI_NAMEs: BASLER, CHRISTOPHER F (contact)

PROJECT_TERMS: Address;Affect;alpha Karyopherins;Antioxidants;Binding;Biological Assay;Biophysics;Cells;Containment;CRISPR/Cas technology;Cytoprotection;Data;Dependence;Disease;Ebola virus;emerging virus;Exhibits;Family;Filovirus;Genes;Genetic Transcription;Goals;Growth;Homologous Gene;Infection;Integration Host Factors;Interferons;Knock-out;Knowledge;Length;Marburgvirus;Mediating;member;MGP gene;Modeling;Modification;Molecular;mutant;Mutation;novel;Nuclear Family;Nuclear Import;Nucleocapsid;Nucleoproteins;Outcome;overexpression;Pathogenesis;Pathway interactions;Peptides;Play;Production;Property;Protein Truncation;Proteins;recombinant virus;Recombinants;Regulation;Reporting;Research Project Grants;response;RNA;RNA analysis;RNA chemical synthesis;RNA Processing;RNA-Protein Interaction;Role;Signal Transduction;Small Interfering RNA;stem;Structure;success;System;Testing;tool;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;Transfection;TRIP10 gene;Viral;viral RNA;Viral Structural Proteins;Virion;Virus;Virus Diseases;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

PROJECT_TERMS: Actins;Address;Affect;Affinity Chromatography;Algorithms;Antibodies;Behavior;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Cell Differentiation process;Cell Physiology;cell type;Cells;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;complex data;Computational algorithm;Computer Models;CRISPR/Cas technology;Data;Data Set;Databases;Disease;domain mapping;Ebola virus;Evaluation;Filoviridae Infections;Filovirus;Fluorescence;follow-up;forest;Genes;Genetic;Genetic Transcription;genome-wide;Inclusion Bodies;Infection;insight;Integration Host Factors;knock-down;knockout gene;Knowledge;large datasets;link protein;Liver;Mass Spectrum Analysis;Measures;Microscopy;Modeling;Molecular;monocyte;mutant;network models;Network-based;novel;Ontology;Optics;Outcome;Outcome Measure;overexpression;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Phosphorylation;Play;Post-Translational Protein Processing;Predisposition;Prize;Probability;Production;protein complex;protein expression;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Records;Regulation;Research Project Grants;Resolution;risk mitigation;RNA;RNA chemical synthesis;RNA Processing;Role;Scheme;screening;Set protein;Small Interfering RNA;Stains;Sumoylation Pathway;synergism;System;Systems Biology;Techniques;Testing;therapy design;tool;Translations;Ubiquitin;Viral;Viral Proteins;viral RNA;Virus;Virus Assembly;Virus Diseases;Virus Replication;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: Roles of host factor protein subnetworks in regulating steps of filovirus infection


ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE  Persistent bloodstream infections are life-threatening emergencies that pose significant challenges to effective treatment. A disease mystery is central to these infections: the causative pathogen is susceptible to antimicrobials in laboratory testing—but not in the human being. Persistent bloodstream infections caused by Staphylococcus aureus and Candida albicans are increasingly common, but there are few therapeutic options and patients frequently succumb. In this U19 Center, we will use state-of-the-art technologies in synergistic research to understand the host-pathogen interactions driving persistence. In turn, these data will be analyzed using powerful computational methods to detect hidden patterns within large complex datasets. As a result, new approaches to identify and treat high risk patients can be developed and applied to improve and save lives. These goals are ideally aligned with priorities of the National Institutes of Health and Centers for Disease Control & Prevention.

PI_NAMEs: YEAMAN, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: KWON, KEEHWAN

PROJECT_TERMS: Acceleration;Address;Algorithms;anti-fungal agents;Anti-Infective Agents;anti-microbial drug;anti-microbial tolerance;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antigens;antimicrobial;Automobile Driving;Bacteremia;biobank;Bioinformatics;Blood;Blood Circulation;Candida;Candida albicans;candidemia;cell injury;Centers for Disease Control and Prevention (U.S.);Chromosomal Rearrangement;chronic infection;Clinical;Communicable Diseases;complex data;Computer Models;Computing Methodologies;cytokine;Data;data management;Data Set;Detection;Diagnostic;Disease;Disseminated candidiasis;DNA Methylation;effective therapy;Emergency Situation;epigenetic memory;Epigenetic Process;epigenome;epigenomics;Etiology;Experimental Models;Fungemia;Gene Expression;Gene Rearrangement;Genetic;Genotype;Goals;Healthcare;Hematogenous;high risk;Hospital Mortality;Human;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunologic Memory;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;innate immune mechanisms;innovation;insight;Intensive Care Units;Intervention;Laboratories;Laboratory Study;Length of Stay;Libraries;Life;Macrophage;Mediating;Memory;methicillin resistant Staphylococcus aureus;Methods;methylomics;Microbial Biofilms;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;neutrophil;Nosocomial Infections;novel;novel strategies;Organ;Outcome;pathogen;Pathogenesis;Patients;Pattern;Pattern recognition receptor;pharmacologic;Phenotype;prediction algorithm;predictive modeling;Predisposition;prevent;Process;Productivity;programs;prospective;prototype;Receptor Signaling;Refractory;Research;Research Project Grants;Resistance;response;Risk;screening;Sepsis;sex;Specificity;Staphylococcus aureus;STAT protein;STAT1 protein;Stress;Study models;success;synergism;System;Systems Biology;Technology;Testing;Therapeutic;therapeutic candidate;Tissues;Training;Translating;United States National Institutes of Health;vaccine strategy;Variant;Virulence;Work

PROJECT_TITLE: Systems Epigenomics of Persistent Bloodstream Infection


PROJECT_TERMS: Academic Medical Centers;Accounting;Achievement;Administrator;Area;Benchmarking;Bioinformatics;Budgets;career;career development;clinical application;Collaborations;Communicable Diseases;Communication;Communities;Computer Models;Computer software;Consultations;cost effective;data dissemination;data management;data sharing;Dedications;design;Development;digital;Discipline;Education;Educational workshop;Ensure;Environment;Epigenetic Process;epigenomics;Equity;equity, diversity, and inclusion;Evaluation;Faculty;FAIR principles;Funding;Goals;Grant;Human Resources;improved;Infrastructure;innovation;International;Intranet;Investigation;Journals;Learning;Life;Manuscripts;Medical;Medical center;meetings;Mining;Modeling;Molecular Medicine;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;Network Infrastructure;novel;Outcome;outreach;pathogen;peer networks;Performance;Policies;Postdoctoral Fellow;predictive modeling;Process;programs;prospective;Publishing;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Sepsis;Services;skills;Students;success;symposium;synergism;System;Systems Biology;Technology;Teleconferences;Time;timeline;translational applications;translational potential;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Prisons concentrate people who inject drugs and people living with HIV, especially in the Commonwealth of Independent States of the former Soviet Union, where the HIV epidemic and drug injectors and their sexual partners remains volatile. Introducing and expanding an evidence-based HIV prevention strategy like opioid substitution therapy within the prisons in a legal, political, and cultural context is fraught with barriers that involve the client, prison staff and the criminal justice infrastructure. Implementation science strategies are effective approaches to study and promote intervention effectiveness that simultaneously works to overcome barriers at each level.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adoption;AIDS prevention;brief intervention;Caring;Central Asia;Client;Collaborations;Commonwealth of Independent States;Communities;community setting;Country;Criminal Justice;Eastern Europe;Educational process of instructing;Effectiveness of Interventions;Ensure;Epidemic;Europe;Evaluation;Evaluation Research;evidence base;Evidence based practice;Foundations;Goals;Health;Health Benefit;Healthcare;High Prevalence;HIV;HIV Infections;Human Rights;implementation science;Imprisonment;improved;Incidence;Individual;Infrastructure;Injecting drug user;innovation;insight;Institutionalized Persons;International;Intervention;Intervention Studies;Justice;Kyrgyzstan;Learning;Legal;Link;Modeling;Moldova;mortality;next generation;opioid agonist therapy;Opioid replacement therapy;opioid use;opioid use disorder;Outcome;Performance;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Policies;Politics;Prevalence;prevent;Prevention strategy;Primary Care;primary care clinic;Prisons;probation;process improvement;Psychiatric therapeutic procedure;Public Health;Research;research and development;Research Personnel;Research Training;routine care;Safety;scale up;screening, brief intervention, referral, and treatment;service delivery;Services;Sexual Partners;Site;skills;success;syndemic;System;Tajikistan;therapy development;tool;Training;transmission process;Ukraine;United States Health Resources and Services Administration;uptake;US State;USSR;Volatilization;Work

PROJECT_TITLE: Prison Interventions and HIV Prevention Collaboration

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


PHR: There is an opioid crisis in the U.S. with significantly increasing mortality risk associated with chronic prescription opioid medication use. Chronic prescription opioid use also increases the risk for sleep apnea and the risk for death in those with both sleep apnea and opioid medication use. However, the exact pathways by which opioids promote sleep apnea remain unknown. There are limited therapies for this disorder. Our research will elucidate the mechanisms by which chronic prescription opioids users develop sleep apnea and will also determine whether oxygen or acetazolamide will reduce or eliminate opioid-related sleep apnea via different pathways. A cumulative effect of our research will fulfil our long-term goal of using novel alternative therapies to alleviate sleep apnea and its associated life-threatening complications in Veterans.

PI_NAMEs: CHOWDHURI, SUSMITA  (contact)

PROJECT_TERMS: Accounting;Acetazolamide;Acute;Adopted;Adult;adverse outcome;Air;Airway Resistance;Alternative Therapies;Animals;Apnea;Arousal;Binding;Breathing;Carbon;Carbon Dioxide;Catheters;Central Sleep Apnea;cerebrovascular;Chemoreceptors;Chronic;chronic pain;Clinic;comparison control;Continuous Positive Airway Pressure;Country;Databases;Development;Disease;Doppler Ultrasound;effective therapy;Emergency Situation;Epidemic;experimental study;genioglossus muscle;Goals;Government;Health;Human;Hypercapnia;Hyperoxia;Hypoventilation;Hypoxia;Individual;innovation;Intervention;Life;Measures;Mediating;mortality;mortality risk;non rapid eye movement;non-opioid analgesic;novel;Opioid;Opioid Analgesics;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid user;Oral;Overdose;overdose death;Oxides;Oxygen;Oxygen Therapy Care;Pathway interactions;Personal Satisfaction;personalized medicine;Pharmaceutical Preparations;Placebos;Plants;Play;Population;preBotzinger complex;prescription opioid;pressure;Reporting;Research;respiratory;response;Risk;Risk Factors;Sampling;Sleep;Sleep Apnea Syndromes;Sleep Disorders Therapy;therapy development;Toxic effect;United States;ventilation;Veterans;Wakefulness

PROJECT_TITLE: Targeting Chemoreceptor Control of Breathing during Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Sepsis

PHR: IMMUNOMIC AND EPIGENOMICS CORE (IEC) PROJECT NARRATIVE Candida albicans candidemia (CAC) is the most common invasive fungal species in hospital settings worldwide. Similarly, methicillin-resistant strains of Staphylococcus aureus (MRSA) can cause invasive and life-threatening infections despite treatment with standard anti-infective therapies. The proposal aims to understand the epigenetic changes in patients infected by MRSA or CAC and the immunologic functions shaping antibiotic- persistent from resolving outcomes. The IEP will provide technical and scientific support in designing and implementing the assays to measure epigenomic and transcriptomic profiles along with immune cells in patients infected by MRSA or CAC.

PI_NAMEs: CAPPELLETTI, MONICA  (contact)

PROJECT_TERMS: adaptive immune response;Anti-Infective Agents;Antibiotics;Area;Bioinformatics;Biological Assay;bisulfite sequencing;Blood;Candida;Candida albicans;candidemia;Cell Culture Techniques;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Consensus Sequence;cost;Data;Data Analyses;data exchange;data management;Data Set;design;Development;disease model;DNA;DNA Methylation;DNA-Protein Interaction;Enhancers;Ensure;Epigenetic Process;epigenome;epigenomics;experimental study;Gene Expression Profile;Generations;Genetic;Genome;Genotype;Goals;Grant;Hospitals;Immune;immune function;Immune response;Immunoassay;immunological diversity;Immunophenotyping;In Vitro;Infection;Innate Immune Response;innovation;interest;Leadership;Libraries;Life;Macrophage;Measures;methicillin resistant Staphylococcus aureus;Microbe;mouse model;next generation sequencing;Outcome;Patient-Focused Outcomes;Patients;Performance;Phenotype;Plasma;Preparation;programs;Protocols documentation;Publishing;Reagent;Research;Research Project Grants;Research Support;Role;Sampling;Sepsis;Services;Shapes;Standardization;System;Technical Expertise;Techniques;Technology;Testing;transcriptome;transcriptome sequencing;transcriptomics;whole genome

PROJECT_TITLE: Immunomics Research Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Hematology;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD);Sepsis

PHR: BDM CORE NARRATIVE The primary functions of the Bioinformatic and Data Management (BDM) Core are to provide 1) data management, 2) bioinformatic and 3) biostatistical analysis support to all the Projects and Cores of this program. The Core is required for proper analysis of data generated within each project, for networking of data across projects for complex analyses by the Computational & Predictive Modeling Core (CPM), and for ensuring the NIH-funded research data is findable, accessible, interoperable, and reusable (i.e., the FAIR principles). Services will be provided in the following areas:  · Data monitoring and management.  · Database infrastructure and storage.  · Data upload into public domain repositories.  · Development and implementation of bioinformatics tools and software to create a central data  processing platform of high throughput biological data.  · Selection of study populations using judicious matching algorithms for enhanced reproducibility of  results and mitigation of confounded conclusions.  · Biostatistical design and standard analysis of project studies.  · Assistance with manuscript preparation.  · Education and career development.

PI_NAMEs: GJERTSON, DAVID  (contact)

PROJECT_TERMS: Address;Algorithms;Area;ATAC-seq;Bioinformatics;bioinformatics tool;Biological;Biometry;bisulfite sequencing;career;career development;Categories;Classification;Collaborations;Complex Analysis;Computer Models;Computer software;computerized data processing;Computers;Data;data access;Data Analyses;data infrastructure;data integration;data management;data quality;data repository;Data Security;Data Set;data sharing;Data Storage and Retrieval;data structure;Databases;design;Development;dimension reduction;Education;Ensure;Epigenetic Process;epigenomics;FAIR principles;falls;Funding;Genes;Goals;Grant;Human Resources;Infection;Infrastructure;Macrophage;Manuscripts;meetings;Metadata;Methodology;Methylation;Modeling;Monitor;Periodicals;Population;predictive modeling;Preparation;Process;programs;Progress Reports;promoter;Public Domains;Quality Control;reference genome;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Personnel;response;Retrieval;Running;Sampling;Sepsis;Services;single-cell RNA sequencing;Site;Statistical Data Interpretation;Statistical Methods;study population;Survival Analysis;System;Systems Biology;Techniques;transcriptome;transcriptome sequencing;United States National Institutes of Health;whole genome;Work

PROJECT_TITLE: Data Management & Bioformatics Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Skin Cancer

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Combined radiation and checkpoint treatment has shown clinical potential for advanced malignancies including melanoma, however, responses outside the radiation field (abscopal effect) still occur in only a minority of patients. This proposal may provide important insight into a novel mechanism for anti-cancer T cell stimulation which is less toxic and has higher local and distant response rates than current approaches. In addition, it may lead to a re-evaluation of the need for and benefit of surgical removal of the tumor-draining lymph nodes.

PI_NAMEs: BUCHWALD, ZACHARY SCOTT (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Abscopal effect;Adjuvant;anti-cancer;anti-PD-1;antigen-specific T cells;arm;Biometry;CD8-Positive T-Lymphocytes;CD8B1 gene;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;cost;Data;Dendritic Cells;Diagnosis;Diphtheria Toxin;diphtheria toxin receptor;Distant;draining lymph node;Effector Cell;Enrollment;Evaluation;Excision;exhaust;exhaustion;first-in-human;Flow Cytometry;Foundations;Genetic Transcription;Goals;high risk;human study;immune checkpoint blockade;Immunofluorescence Immunologic;Immunologics;immunostimulatory therapy;Impairment;improved;improved outcome;innovation;insight;irradiation;ITGAX gene;Knock-in;lymph nodes;Malignant Neoplasms;Measurement;Mediating;Mediator;Melanoma;Melanoma patient;Methods;Minority;Modeling;mouse model;Mus;Neoadjuvant Therapy;Newly Diagnosed;novel;Outcome;Patients;Peptide/MHC Complex;Phenotype;Pilot Projects;pre-clinical;preclinical study;Primary Neoplasm;Prognosis;programmed cell death protein 1;Proliferating;promoter;Radiation;Radiation-Induced Change;Randomized;receptor expression;response;Role;Sampling;single-cell RNA sequencing;Sorting;standard of care;stem;survival outcome;synergism;T cell infiltration;T cell response;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;Toxic effect;Training;transcriptome sequencing;treatment comparison;tumor;Tumor Immunity;Unresectable

PROJECT_TITLE: The role of stem-like CD8 T-cells in the abscopal response

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Recruiting the immune system to recognize and attack tumors is a promising way to treat a wide range of malignancies. However, only a small portion of the cancer cell surfaces can be recognized by immune cells as cancerous. The goals of this proposal are to identify molecular features exclusive to malignant cells and develop tools to mount an antitumoral immune response against them.

PI_NAMEs: YAO, ZI  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Affinity;Alleles;Alternative Splicing;anti-tumor immune response;Antibodies;antibody engineering;Antigen Presentation;Antitumor Response;arm;Autoimmune;Benchmarking;Biological;Biological Assay;Biological Products;BRAF gene;cancer cell;Cancer cell line;cancer type;Cancerous;Cell Line;Cell model;Cell surface;cell transformation;Cells;chimeric antigen receptor;Complex;Cultured Cells;Cytotoxic T-Lymphocytes;Data;Databases;design;Development;Disease;disease model;driver mutation;Engineering;Epidermal Growth Factor Receptor;Epitopes;Foundations;Future;Generations;Genetic Transcription;Goals;HLA Antigens;humanized mouse;Immune;Immune response;Immune system;Immunologic Surveillance;Immunotherapy;In Vitro;in vivo;Individual;inhibitor;insight;interest;Intervention;Investigation;KRAS2 gene;Malignant Neoplasms;Maps;Mass Spectrum Analysis;MEKs;Membrane Proteins;Modality;Molecular;mouse model;Mutate;Mutation;neoantigens;Non-Small-Cell Lung Carcinoma;novel;Oncogene Activation;Oncogenes;Oncogenic;Oncoproteins;overexpression;Parents;patient population;Patients;Peptides;Phage Display;Phenotype;prostate cancer cell line;Protein Databases;Proteins;Proteolysis;Proteome;Reagent;Recombinant Antibody;Recovery;recruit;Research;RNA Splicing;Safety;Sampling;Shapes;Signal Pathway;Signal Transduction;Specificity;Surveys;SwissProt;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapeutic target;tool;Transcript;tumor;tumor eradication;Tumor Immunity;Tumor Specific Peptide;tumorigenesis;vector control;Work

PROJECT_TITLE: Mapping tumor specific immunopeptidome for antibody-based targeted therapy


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Sepsis

PHR: PROJECT NARRATIVE Staphylococcus aureus and Candida albicans are both organisms that are commonly found on healthy individuals without causing problems but lead to deadly infections in some. The Computational & Predictive Modeling Core will lead the development of new computational algorithms for pattern matching across datasets, to identify commonalities across different types of measurements and between both types of infections. Doing so will improve our ability to predict the outcome of infection and our understanding of how these infections become life-threatening.

PI_NAMEs: MEYER, AARON SAMUEL (contact)

PROJECT_TERMS: 3-Dimensional;Age;Antibiotics;Biological Models;Candida albicans;Clinical;cohort;Cohort Studies;Collaborations;Communities;Computational algorithm;Computer Models;Coupled;cytokine;Data;data integration;data modeling;Data Set;Development;dimension reduction;dynamic system;effective therapy;Effectiveness;Epigenetic Process;epigenomics;Experimental Models;Gene Expression;Genes;Genetic;Genetic Transcription;Healthcare;Human;Immune Evasion;Immune response;immunodeficiency;Immunologics;improved;In Vitro;Individual;individual patient;Infection;Lead;Life;Longitudinal Studies;Machine Learning;Measurement;methicillin resistant Staphylococcus aureus;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Profiling;mortality;mouse model;Multiomic Data;Mus;Natural Immunity;Nature;Noise;novel;Organism;Outcome;outcome prediction;pathogen;Pattern;permissiveness;Pharmaceutical Preparations;Phenotype;Physiological Processes;predictive modeling;primary outcome;Principal Component Analysis;Property;Proteomics;Research Personnel;response;Sampling;Sepsis;Series;sex;Staphylococcus aureus;System;Systems Analysis;Techniques;Technology;Testing;Time;tool;Training;transcriptome sequencing;transcriptomics;Treatment outcome;Variant;Visualization;Work

PROJECT_TITLE: Computational Modeling Core


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pulmonary Fibrosis

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Pulmonary fibrosis represents a global clinical burden that affects over 5,00,000 people and can occur as a result of chemical injury, chronic disease, or respiratory infection. This project aims to establish a spatiotemporal atlas of the cellular subtypes, interaction networks, and matrix architectures that mediate pathological progression of pulmonary fibrosis as well as post-fibrotic repair, including mesenchymal subpopulations. This systems-level analysis of pulmonary fibrosis will help identify novel targets for both clinical prognosis and therapeutic development.

PI_NAMEs: GUO, JASON LIWEI (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Affect;Architecture;Atlases;biocomputing;Bioinformatics;Biological;Biological Models;Biophysics;Breathing;Cell Communication;Cells;cellular targeting;Chemical Injury;Chronic;Chronic Disease;Clinical;clinical prognosis;clinically relevant;computational atlas;Computer Models;COVID-19;Data;Deposition;Diagnosis;Epigenetic Process;epigenomics;Evolution;Extracellular Matrix;Fibroblasts;Fibrosis;Genetic Transcription;Goals;Heterogeneity;Histologic;Human;idiopathic pulmonary fibrosis;immunoregulation;in vivo;indium-bleomycin;Individual;Influenza;interstitial;Kinetics;lens;Linear Regressions;Link;Location;Lung;lung repair;Machine Learning;machine learning algorithm;machine learning model;Macrophage;Mediating;Mediator;Mesenchymal;Metadata;Modeling;Molecular Target;mouse model;multiple omics;Mus;Neighborhoods;novel;Organ;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Persons;Phenotype;Play;Population;Prognosis;Proteins;Pulmonary Fibrosis;Regression Analysis;repaired;Resolution;Respiratory Tract Infections;RNA;Role;Science;single-cell RNA sequencing;Slice;spatiotemporal;Specimen;survival prediction;System;Systemic Scleroderma;Techniques;therapeutic development;Time;Tissue-Specific Gene Expression;Tissues;transcriptomics;Validation;Variant

PROJECT_TITLE: Spatiotemporal Atlas of Cellular Networks and Ultrastructural States Mediating the Progression and Resolution of Pulmonary Fibrosis


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Hematology;Immunization;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE The overall goal of the proposed study is to better understand the molecular pathogenesis of immune thrombotic thrombocytopenic purpura (iTTP) using various biochemical, molecular and cellular biological tools, and animal models, as well as iTTP patients. The project will focus on identifying the structural signatures and mechanism of action of human monoclonal IgG antibodies isolated through single B cell Ig sequencing, and uncovering the potential role of ANKRD26/36 gene family in the zebrafish and murine models of iTTP. We believe that the results of the proposed study may change how we manage patients with iTTP in the future.

PI_NAMEs: ZHENG, X. LONG  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: 5' Untranslated Regions;Acute;ADAMTS;Adrenal Cortex Hormones;Agglutination;Allosteric Regulation;Animal Model;Antibodies;Ants;arteriole;Autoantibodies;Autoantibody binding;B-Lymphocytes;Biochemical;Biological;Biological Process;biophysical techniques;Blood;Blood capillaries;Blood Platelets;Cessation of life;Chromium;Clonality;Code;complementarity-determining region 3;Disease;Disease remission;Disintegrins;Elements;Endothelial Cells;Endothelium;Evolution;experience;Family;Flow Cytometry;Future;gain of function;Gene Family;Generations;Genetic;Genomics;Goals;Hematological Disease;Hematopoiesis;Hemolytic Anemia;Hemostatic Agents;Hepatic Stellate Cell;Human;human monoclonal antibodies;Immune;Immunoglobulin G;Immunoglobulin Variable Region;Immunoglobulins;Immunological Models;Immunologics;Inflammation;Inflammatory Response;Inherited;Knowledge;loss of function;Mass Spectrum Analysis;Mediating;Megakaryocytopoieses;member;Memory B-Lymphocyte;Metalloproteases;Molecular;Molecular Profiling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mutation;nanobodies;novel;novel therapeutic intervention;organ injury;Outcome;Pathogenesis;Pathology;Patients;Phenotype;Plasma;Plasmapheresis;Production;Protein Family;Proteome;Publishing;Reagent;Refractory Disease;rituximab;Role;sequencing platform;standard of care;Stream;Structure;Testing;Therapeutic Intervention;Thrombocytopenia;Thrombocytopenic Purpura;thrombogenesis;Thrombosis;Thrombospondins;thrombotic;Thrombotic Thrombocytopenic Purpura;Thrombus;tool;V(D)J Recombination;von Willebrand Factor;Zebrafish

PROJECT_TITLE: Pathogenesis of thrombotic microangiopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease

PHR: Narrative NLRP6 Inflammasome has been reported to play dual roles in defense against pathogen evasion and promoting autoinflammatory syndromes resulting from excessive signaling. Fine-tuning the NLRP6 inflammasome activity through essential cellular processes remains poorly understood, which is critical for homeostasis of NLRP6-expressing tissues. This proposal will investigate the role of nuclear import receptors in the regulation of NLRP6 inflammasome activity.

PI_NAMEs: SHEN, CHEN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Adaptor Signaling Protein;Affect;American;autoinflammatory;Binding;Biochemical;Biochemistry;Biological Assay;Biology;CASP1 gene;Caspase;Cell Death;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Chronic Disease;chronic inflammatory disease;Co-Immunoprecipitations;Colon;Complex;Crohn's disease;Cryoelectron Microscopy;cytokine;Cytosol;dextran sulfate sodium induced colitis;Disease;Double-Stranded RNA;Drug Targeting;Event;experimental study;Gastrointestinal tract structure;Homeostasis;Host Defense;Hyperactivity;IL18 gene;Image;Immune;Importins;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;Interferons;Interleukins;Intestines;Leucine-Rich Repeat;Light;Link;Liquid substance;Liver;Mass Spectrum Analysis;Mediating;meter;Molecular;Molecular Machines;Monitor;Mus;mutant;Mutation;novel;Nuclear Import;Nuclear Translocation;nucleocytoplasmic transport;Nucleotides;Outcome;pathogen;Phase;Plants;Play;polymerization;Polymers;prevent;Process;Production;Protein Family;Proteins;Publishing;receptor;recruit;Regulation;Reporting;response;RNA-Binding Proteins;Role;scaffold;sensor;Signal Induction;Signal Transduction;Signaling Protein;Structure;Syndrome;targeted treatment;Testing;Therapeutic Intervention;tissue injury;Tissues;tool;transcription factor;transport inhibitor;Ulcerative Colitis;VDAC1 gene;Viral;Virus;Virus Diseases;Western Blotting

PROJECT_TITLE: Elucidating the novel mechanism of importins in NLRP6 inflammasome regulation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Prevention;Sepsis

PHR: PROJECT NARRATIVE  Persistent bloodstream infections caused by Staphylococcus aureus are life-threatening emergencies that are increasingly common. An essential unanswered question is at the root of these infections: the pathogen is susceptible to antibiotics in laboratory testing—but not in the human being. There are few therapeutic options in these cases and patients frequently succumb. In this research, we will use state-of-the-art technologies in systems-based research to understand the host-pathogen interactions driving persistence. Powerful computational methods will be used to detect hidden patterns within large complex datasets. As a result, new approaches to identify and treat high risk patients will be discovered and applied to improve and save lives. These goals ideally align to National Institutes of Health priorities.

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Anti-Infective Agents;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Automobile Driving;Bacteremia;Bioinformatics;Biological Assay;Blood;Blood Circulation;Cessation of life;Characteristics;chronic infection;Clinical;Clinical Trials;cohort;comparative;complex data;Computing Methodologies;Cross-Priming;cytokine;Data;Data Set;design;Diagnostic;Dimensions;DNA;DNA Methylation;DNA Modification Methylases;Emergency Situation;Epigenetic Process;epigenomics;Equation;Etiology;experience;Experimental Models;Foundations;Gene Deletion;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genome sequencing;Genotype;Goals;Health Priorities;Hematogenous;high risk;Human;human DNA;Immune;Immune response;Immunity;Immunologic Memory;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Infection;inhibitor;innovation;insight;Interleukin-10;Intervention;Kidney;Knowledge;Laboratories;Life;Macrophage;male;Maps;Mediating;Memory;methicillin resistant Staphylococcus aureus;Methods;Methylation;Methyltransferase;Microbial Biofilms;Molecular;multi-drug resistant pathogen;Mus;neutrophil;novel;novel strategies;Organism;Outcome;pathogen;Patients;Pattern;Phagosomes;pharmacologic;Phenotype;Predisposition;prevent;priority pathogen;Production;protective efficacy;Rag1 Mouse;Refractory;Regimen;Research;resistance gene;Sepsis;sex;Shapes;single molecule real time sequencing;Specific qualifier value;Spleen;Staphylococcus aureus;Staphylococcus aureus infection;Stress;success;synergism;System;Systems Biology;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;translatable strategy;Translating;United States National Institutes of Health;Vaccination;vaccine strategy;Vaccines;Vancomycin;Variant;Virulence;virulence gene;whole genome

PROJECT_TITLE: Epigenomic Mechanisms & Contextual Immunity in Persistent MRSA Bacteremia


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

PHR: Over the last two decades, the field of IDD has become increasingly interdisciplinary, biobehavioral, and translational. The Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities has historically provided a unique venue for the exposition and discussion of the latest biobehavioral research findings, methods, and theoretical frameworks in IDD research. The conference has held a key place in the development of the IDD field. It has launched new interdisciplinary collaborations relevant to IDD, has nurtured and supported the careers of a diverse pool of junior researchers working in IDD, and has been the most critical venue for the bringing constructs and findings from basic science disciplines to the IDD research community. Ultimately, the conference shapes the biobehavioral scientific agenda of the IDD field and accelerates efforts to translate research results into innovative programs of treatment and prevention that will improve the lives of people with IDD and their families.

PI_NAMEs: COLOMBO, JOHN A. (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Acceleration;Address;American;American Psychological Association;Applied Research;Attention;Award;Basic Science;Behavioral Sciences;biobehavior;Bite;career;career development;Child Development;Cities;Collaborations;college;Communication;Communities;comorbidity;cost;design;Development;disability;Disability research;Discipline;Disease;early-career faculty;Empirical Research;Ensure;Ethics;experience;Exposure to;Extramural Activities;Family;field study;Fostering;Funding;Goals;graduate student;Grant;improved;improved outcome;Individual;innovation;Intellectual functioning disability;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Kansas;Leadership;lectures;Location;Medicine;meetings;Mentors;Methodology;Methods;Modeling;National Institute of Child Health and Human Development;Neurobiology;next generation;Participant;Persons;Policies;Postdoctoral Fellow;posters;pre-clinical;Prevention;Productivity;programs;Recording of previous events;Reproducibility;Research;Research Personnel;Resource Development;Resource Sharing;responsible research conduct;Science;Scientist;Senior Scientist;Services;Shapes;Site;skills;Societies;Students;symposium;theories;Therapeutic;therapy design;Time;Training;Translating;translational neuroscience;Translational Research;Travel;treatment program;Underrepresented Populations;Universities;Voting;Work

PROJECT_TITLE: Gatlinburg Conference on Research in ID/DD

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Human gammaherpesviruses establish life-long infection in their host by latently infecting resting memory B- cells, however, the mechanism of how this cellular reservoir is established and maintained remains unclear. Polo-like kinase 1 (PLK1) is an important kinase involved in cell cycle control, which we recently discovered to have a critical role in both initiation of γ-herpesviruses latency and survival of viral-infected cells. Further dissection of PLK1’s role in regulation of γ−herpesviruses reservoirs will be valuable for devising therapies that can completely eliminate the pathogens and, in turn, prevent any related malignancies.

PI_NAMEs: SANTOSO, NETTY G (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Activated B-Lymphocyte;Activated Lymphocyte;Address;Affect;AIDS-Related Lymphoma;Anti-viral Agents;Apoptosis;Attenuated;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;biological adaptation to stress;Burkitt Lymphoma;Cancer Etiology;cancer therapy;carcinogenesis;CD4 Positive T Lymphocytes;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell Proliferation;Cell Survival;Cells;Cellular Tropism;Cessation of life;Chemicals;Chromatin;chronic infection;Clinical Trials;co-infection;Development;Dissection;DNA Damage;Double Stranded DNA Virus;Drug Combinations;effective therapy;Epstein-Barr Virus latency;Etiology;feasibility testing;gammaherpesvirus;Herpesviridae;Herpesviridae Infections;HIV;HIV Infections;HIV Seropositivity;HIV-1;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune signaling;Immunocompromised Host;immunodeficiency;Individual;infected B cell;Infection;Infectious Agent;Inhibition of Cell Proliferation;inhibitor;Investigation;Kaposi Sarcoma;kinase inhibitor;knock-down;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;latent infection;Life;Link;Lymphocyte;Lymphoid Cell;Lymphoma;Lymphoproliferative Disorders;lytic replication;M cell;Maintenance;Malignant Neoplasms;Mediating;Memory B-Lymphocyte;Molecular;Molecular Target;Nasopharynx Carcinoma;nef Protein;neoplastic cell;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;Nuclear;Oncogenic;Oncolytic;Organ Transplantation;overexpression;Oxidative Stress;pathogen;Patients;Persons;Phosphotransferases;Play;PLK1 gene;polo-like kinase kinase 1;Post-Translational Protein Processing;Predisposition;prevent;primary effusion lymphoma;Primary Infection;Process;Production;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogenes;Regimen;Regulation;Reporting;Research;response;Rest;Risk;Risk Factors;Role;Serine;Shock;Signal Transduction;Soft Tissue Neoplasms;Specific qualifier value;Stomach Carcinoma;Stress;Sumoylation Pathway;T-Lymphocyte;targeted cancer therapy;Therapeutic;TP53 gene;tumorigenesis;Viral;Viral Proteins;Viral reservoir;Virus;Virus Activation;Virus Diseases;Virus Latency;virus related cancer

PROJECT_TITLE: (PQ4) Role of HIV-induced PLK1 Activation in Regulation of gamma-Herpesvirus Reservoirs in Lymphocytes


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Prevention;Sepsis

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Acinetobacter baumannii is one of the few types of bacteria that has become resistant to every antibiotic available. New treatments are desperately needed, since the death rate from these infections that are resistant to all antibiotics is high, and no new antibiotics that can kill A. baumannii are in development. The purpose of the current grant is to use the immune system to treat these infections using a vaccine made up of special proteins called antibodies.

PI_NAMEs: SPELLBERG, BRAD J (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Adoption;Amino Acid Sequence;Anti-Bacterial Agents;Antibiotic susceptibility;Antibiotics;Antibodies;Bacteremia;Bacteria;bacterial resistance;Binding;Biological Assay;Blood;capsule;Cells;Cessation of life;China;CLIA certified;Clinical;clinical development;Clinical Microbiology;Clinical Trials;Collection;cytokine;Death Rate;Developed Countries;Development;Dose;Drug resistance;efficacy evaluation;Ensure;Europe;Evaluation;Exposure to;Future;Goals;Grant;Health Care Costs;high throughput screening;HL60;Human;Immune system;improved outcome;In Vitro;in vivo;in vivo evaluation;Individual;Infection;infection rate;Inflammatory Response;International;Laboratories;Lead;lead candidate;Leukocytes;Lung infections;Macrophage;Manuals;manufacturing cost;Mediating;Modeling;Multivariate Analysis;Mus;news;novel;operation;Outcome;Passive Immunization;pathogen;Patients;Phase;Phase I Clinical Trials;Plasma;pneumonia model;preclinical development;Predisposition;prevent;Progress Reports;Proteins;rapid test;Regimen;Reporting;research clinical testing;Resistance;Sepsis;Serum;South America;Southeastern Asia;statistics;Surrogate Markers;Surveys;synergism;Taiwan;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Time;Toxic effect;Translations;uptake;Vaccines;virtual;Work

PROJECT_TITLE: MAb Passive Vaccination against Acinetobacter baumannii

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative There is an acute shortage of well-trained MD and PhD investigators performing high impact cardiovascular research to combat the burden of cardiovascular disease. The University of Pennsylvania Cardiovascular Institute’s training program in cardiovascular biology and medicine is uniquely positioned to prepare MD and PhD postdoctoral trainees for successful careers in cardiovascular biomedical science. Our aim is to equip the next generation of cardiovascular scientists with the latest tools to improve cardiovascular health.

PI_NAMEs: CAPPOLA, THOMAS P. (contact);KELLY, DANIEL PATRICK

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TITLE: Training Program in Cardiovascular Biology and Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The effects of music on memory in naturalistic settings are not yet well understood. In this  project, we aim to study how memory for films is affected by the presence or absence of the film  score and whether these effects can be measured neurally. This work will help develop new  neural measures of music-evoked episodic memory as well as expand our understanding of music's  effect on memory under natural conditions.

PI_NAMEs: WILLIAMS, JAMAL A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Area;Award;Back;Basic Science;Behavior;Behavioral;Behavioral Paradigm;Brain;Chronology;Clinical;cognitive neuroscience;Comprehension;Control Groups;Cues;Data;Distant;Electroencephalography;Episodic memory;Event;experience;experimental study;Film;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Goals;Hearing;Human;improved;Infant;insight;Investigation;Knowledge;Label;Learning;learning algorithm;Life;Machine Learning;markov model;Measures;Memory;Memory impairment;memory recall;memory retrieval;Mind;Modernization;movie;Music;neural;Neurosciences;novel;Participant;Patient Recruitments;Performance;Phase;Play;Population;portability;Postdoctoral Fellow;preservation;Recurrence;Research;Research Project Grants;Retrieval;Role;Running;Sensory;Shapes;skill acquisition;sound;Specific qualifier value;Stimulus;Structure;Techniques;Testing;theories;Time;unsupervised learning;Work

PROJECT_TITLE: The effects of film music on neural activity in higher-order brain areas and comprehension for the film narrative