FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: 8. Project Narrative The aim of this proposal is to determine how microglia, the central nervous system macrophages, contribute to disease progression in models of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). I will explore how loss of expression of a proinflammatory molecule, gasdermin-D, impacts survival and changes microglial immune responses in two discrete mouse models of ALS and FTD. This will further our understanding of how microglial reactivity impacts neuron health and potentially unveil novel druggable targets to ameliorate disease progression.

PI_NAMEs: GUNNER, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Age;Amyotrophic Lateral Sclerosis;Animals;Area;Arginine;Biology;Brain;brain parenchyma;C9ORF72;career;cell cortex;Cell Death;Central Nervous System;Cessation of life;Coculture Techniques;Collaborations;cytokine;Data;Development;Dipeptides;Disease;Disease associated microglia;disease model;Disease Progression;DNA Sequence Alteration;Dyes;experimental study;Exposure to;Flow Cytometry;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Expression Profile;genetic signature;Genetic Transcription;Genotype;glial activation;Gliosis;Glycine;Goals;Health;Heterogeneity;Human;Immune;immune function;Immune response;Immunology;Impaired cognition;In Vitro;Inflammasome;Inflammation;Inflammatory;Injections;Institution;Investigation;Link;Location;Macrophage;Mediating;Mentors;Metabolic;Metabolic stress;Microglia;Mitochondria;Modeling;Motor Cortex;Motor Neurons;mouse model;Mus;mutant;Mutation;Neonatal;Nerve Degeneration;neural circuit;Neurites;Neurobiology;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprotection;new therapeutic target;Onset of illness;overexpression;Paralysed;Pathology;Patients;Peripheral;Population;Positioning Attribute;Principal Investigator;Process;programs;Proline;protein expression;Protein Overexpression;protein TDP-43;Proteins;pup;response;Role;Severities;Severity of illness;single-cell RNA sequencing;skills;Spinal Cord;Stains;Stress;Superoxide Dismutase;survival outcome;Techniques;Testing;Time;Tissues;Training;transcriptomics;Transgenic Organisms;VDAC1 gene;Viral;Virus;Weaning;Work

PROJECT_TITLE: The role of gasdermins in microglial activation and neurodegeneration in ALS/FTD


ADMINISTERING_IC: FD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: INDIANA STATE DEPARTMENT OF HEALTH

ORG_STATE: IN

PHR: Project Narrative The Indiana Department of Health – Food Protection Division is committed to maintaining high regulatory program standards. The objectives outlined in this proposal will enable the division to not only meet, but exceed these standards by shifting program resources to a more preventive and collaborative approach to food safety regulation and illness prevention.

PI_NAMEs: YOUNG, JORDAN  (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, JENNIFER

PROJECT_TITLE: MFRPS Maintenance - Indiana Department of Health Food Protection Division


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Patient Safety

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: SOKOLL, LORI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Clinical;clinical trial protocol;Clinical Trials;Contractor;Contracts;Data;Data Management Resources;electronic data;Ensure;Funding;Future;improved;Individual;International;Laboratories;Licensing;Monitor;National Institute of Allergy and Infectious Disease;operation;patient safety;Protocols documentation;Readiness;Safety;Specific qualifier value;Test Result;Testing;Training;Work

PROJECT_TITLE: Patient Safety Monitoring in International Laboratories (SMILE)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ADMINISTRATION

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The short-term goal of this K99/R00 application is the development of the PI as an independent investigator skilled in the use of participatory systems science and community-engaged approaches to select and adapt an intervention, lung cancer prevention and risk reduction interventions, and intervention development and implementation science. The proposed research will select and adapt an intervention protocol to reduce lung cancer risk among Central Appalachian Kentucky women through a community-engaged process and will pilot test the selected intervention using a two-armed randomized controlled trial. The long-term goal is to reduce lung cancer disparities among Appalachian women and for the PI to become an independent researcher and expert in community-engaged intervention development for cancer risk reduction among Appalachian women.

PI_NAMEs: THOMPSON, JESSICA RUTH (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: 18 year old;Active Learning;Address;Appalachian Region;Area;Attitude;Awareness;Behavior;Behavior Therapy;Behavioral;Cancer Center;Cancer Etiology;cancer health disparity;Cancer Intervention;cancer risk;care giving burden;career development;Chronic Disease;Chronic stress;clinical center;Clinical Sciences;Communities;community center;community collaboration;community engaged approach;community engaged intervention;community engagement process;community partners;community-level factor;Coping Behavior;Country;County;Death Rate;Development;Development Plans;disorder prevention;disparities in women;Disproportionately impacts women;Economically Deprived Population;Effectiveness of Interventions;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Equity;Evidence based intervention;experience;falls;Farm;Funding;Future;Gender;geographic disparity;Goals;Health;health care availability;health disparity;health disparity populations;health economics;health equity;Health Technology;High Risk Woman;human centered design;implementation cost;implementation science;improved;Incidence;Individual;Insurance;Intervention;intervention mapping;intervention refinement;Intervention Studies;Intervention Trial;Kentucky;Knowledge;Literature;lung cancer prevention;Malignant neoplasm of lung;Malignant Neoplasms;men;Mentors;Mentorship;Methods;Mining;model building;Modeling;mortality;NCI-Designated Cancer Center;Needs Assessment;non-smoker;Participant;Passive Smoking;Perception;Persons;Phase;pilot test;Population;Postdoctoral Fellow;Poverty;Preventive;Preventive screening;Preventive service;primary care provider;Process;Protocols documentation;Psychosocial Factor;public policy on tobacco;Quality of life;Radon;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Risk Reduction;Rural;Rural Appalachia;Sample Size;satisfaction;Science;Scientist;Self Efficacy;Series;service providers;sex;skills;Smoking;social;socioeconomic disadvantage;socioeconomic disparity;Source;Specificity;Surveys;System;Targeted Research;therapy development;Training;training opportunity;Translational Research;Trust;United States National Institutes of Health;Universities;Water;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: Reducing Lung Cancer Risk among Appalachian Women Using Community‐Engaged Intervention Research


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Many cortical and subcortical brain regions work together to coordinate social emotional brain states. In this study we propose to build a model from experimental data that explains how these regions work together to generate aggression. We will test this model using established and emerging therapeutics utilized to treat aggression in the clinic, and we will develop new brain stimulation methodologies to regulate aggressive brain states uncovered by our model.

PI_NAMEs: CARLSON, DAVID E;DZIRASA, KAFUI  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Action Potentials;Address;Aggressive behavior;Agonist;Animals;Architecture;Atlases;Behavior;Behavior Control;Behavioral Paradigm;Biological;Blood;Brain;brain cell;Brain region;Catalogs;Cells;cellular targeting;Chemicals;Clinic;Communication;Complex;connectome;Cues;Data;designer receptors exclusively activated by designer drugs;Development;Dopamine;Electrodes;Emotional;emotional behavior;Emotions;Etiology;Experimental Models;experimental study;explainable artificial intelligence;Eye;free behavior;Functional Magnetic Resonance Imaging;Goals;Guanfacine;Habenula;Hour;Human;human subject;Hypothalamic structure;imaging study;Imaging Techniques;Implant;in vivo;Individual;information processing;instrument;Lateral;Learning;Link;Machine Learning;machine learning method;Mammals;Measures;Mediating;Methodology;Methods;millisecond;Modeling;Molecular;Monitor;Motor;multidisciplinary;Mus;Muscle;Music;network models;neural;neuroregulation;Neurosciences;Output;Oxytocin;Peptides;Physiological;Play;Prefrontal Cortex;Process;receptor;Research;Resolution;Rodent;Role;Sensorimotor functions;sensorimotor system;Serotonin;Signal Transduction;Site;Sleep;social;Social Network;spatial integration;spatiotemporal;Stream;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Viral;Vision;Work

PROJECT_TITLE: MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOLOGY

ORG_NAME: LEHIGH UNIVERSITY

PHR: Below is the Original Narrative to fill this Mandatory Field PROJECT NARRATIVE  Adaptive genome evolution has produced the remarkable diversity of life on Earth, yet it is also the process by which pathogens and cancers resist drug treatments and evade the immune system. High- throughput experimental evolution is a powerful and versatile technique that provides a way to test evolutionary theory in the laboratory with exquisite control over experimental parameters. By identifying the genes and pathways that respond to selective pressures, the proposed experiments will not only advance our understanding of the process of adaptive evolution but will lead to new mechanistic insights into how genetic variation produces the phenotypes on which selection acts.

PI_NAMEs: LANG, GREGORY I (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Antibiotic Resistance;Biological Assay;Biology;Complex;Cytoplasm;Environment;Evolution;experimental study;functional genomics;Future;gene environment interaction;Gene Pool;Generations;Genes;Genetic;Genetic Variation;Genome;Genotype;Health;Human;human pathogen;Immune Evasion;Immune system;insight;Knowledge;Laboratories;Life;Malignant Neoplasms;Methods;Mutation;Nuclear;pathogen;pathogenic virus;Pathway interactions;Pharmacotherapy;Phenotype;Planet Earth;Population;pressure;Process;purge;System;Techniques;Testing;theories;Time;tool;trait;Variant;Work;Yeasts

PROJECT_TITLE: Genetic interactions and the evolution of complex traits in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Digestive Diseases;Foodborne Illness;Rare Diseases;Social Determinants of Health

ORG_CITY: FORT MYERS

ORG_NAME: FLORIDA GULF COAST UNIVERSITY

ORG_STATE: FL

PI_NAMEs: PARSONS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Affect;Area;Calibration;Caribbean region;Cell Density;Cells;Ciguatera Poisoning;Ciguatoxins;Climate;climate change;climate impact;Communities;Computer Models;Consumption;contaminated fish;coral;Data;Dinophyceae;Disease;DNA sequencing;Ecology;economic impact;Ecosystem;Environment;environmental change;Environmental Impact;Event;extreme temperature;Florida;Food Webs;Frequencies;Gambierdiscus;Geography;Goals;Growth;Habitats;harmful algal blooms;Health protection;Incidence;Industry;innovation;Investigation;Island;Laboratory Study;Link;marine;member;migration;Modeling;models and simulation;Natural experiment;Pathway interactions;Pattern;Persons;Physiology;Population;Population Dynamics;Prevalence;Process;Public Health;Research;Research Project Grants;resilience;response;Risk;risk prediction;Sea;Seafood;Seasons;Sentinel;Site;Societies;spatiotemporal;Surface;Techniques;Temperature;thermal stress;tool;Toxic effect;Toxin;United States Virgin Islands;Water;Work

PROJECT_TITLE: Research Project 1


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Digestive Diseases;Foodborne Illness;Rare Diseases

PHR: Ciguatera fish poisoning (CFP) is a form of seafood poisoning that affects tens of thousands of people on an annual basis, and is expected to increase with climate change impacts. There is no practical way to screen seafood to safeguard for consumption, nor reliable diagnoses and treatment options for people afflicted with CFP. The Greater Caribbean Center for Ciguatera Research aims to identify the mechanisms of toxin production and transport into at-risk seafood, and to examine the mechanisms of toxicity on a cellular level, in order to better protect and treat people from this malady in an era of climate change processes.

PROJECT_TERMS: Abdominal Pain;Affect;Alabama;bioaccumulation;Bradycardia;Caribbean region;Cell Wall;Cells;Cellular biology;Ciguatera Poisoning;Ciguatoxins;climate change;Communities;community engagement;Consumption;contaminated fish;coral;Coupled;Detection;Development;Diagnosis;Diarrhea;Dinophyceae;Disease;Disease Outbreaks;Dysesthesias;economic impact;Educational Activities;Event;experience;exposed human population;Exposure to;Fisheries;Fishes;Florida;Flowers;Food Webs;Frequencies;Future;Gambierdiscus;gastrointestinal symptom;genotoxicity;Geography;Goals;Growth;gulf coast;High temperature of physical object;Hypotension;Institution;Ion Channel Gating;Island;Laboratories;Link;Lipids;Louisiana;Malignant Neoplasms;marine;Measures;Medical;Membrane;Metabolic Biotransformation;Metabolism;Mexico;Molecular;mortality;Movement;Muscle;Myalgia;Nature;Nausea;Nerve;Nerve Tissue;Neurologic Signs;Neurologic Symptoms;neuronal excitability;Neurotoxins;novel;Oceanography;organizational structure;Output;Permeability;Persons;Physiological;Play;Prevention;Process;Production;Pruritus;Public Health;Puerto Rico;Recreation;Research;Research Project Grants;response;Rest;Risk;Role;Science;Scientist;Sea;Seafood;seafood poisoning;Secure;sodium ion;Stress;Surface;Symptoms;synergism;Temperature;Testing;Tetrodotoxin;Texas;toxic algae;Toxic effect;Toxin;Translating;United States;United States Virgin Islands;Universities;voltage;Vomiting;Vulnerable Populations;Water;Work


ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Our studies will reveal how immune receptors recognize and respond to viral infections; understanding their fundamental biochemical properties will pave ways to develop new antivirals, vaccine adjuvants, immune activators. Our research will provide the mechanisms of enzymes that transcribe and replicate the human mitochondrial DNA whose maintenance is vital for energy production. This foundational knowledge will provide the basis to discover treatments for mitochondrial related diseases caused by malfunctions of these enzymes.

PI_NAMEs: PATEL, SMITA S (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Anti-viral Agents;ATP phosphohydrolase;Bacteriophage T7;Binding Proteins;Biochemical;Biochemical Reaction;Biological Assay;biophysical techniques;Coupled;Cryoelectron Microscopy;Defect;Development;Disease;DNA;DNA biosynthesis;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;enzyme mechanism;Enzymes;first responder;Genetic Transcription;Goals;helicase;Human;immune activator;Immune response;Immunologic Receptors;In Vitro;kinetic model;Kinetics;Knowledge;Maintenance;Malignant Neoplasms;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial RNA;Modeling;Molecular;Natural Immunity;Nucleic Acids;pathogen;Pattern;Polymerase;Process;Production;Property;Reaction;receptor;reconstitution;Regulation;Research;RNA;RNA Virus Infections;Role;Signal Transduction;single molecule;Structure;therapy development;transcription factor;Transcription Initiation;Vaccine Adjuvant;Viral;Viral Genome;viral RNA;Virus Diseases;Virus Replication;Work;Yeasts

PROJECT_TITLE: Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity.


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative This application seeks to continue long-standing support for the UCSD Medical Scientist (M.D./Ph.D.) Training Program (MSTP), which combines both M.D. (through an Integrated Scientific Curriculum in the UCSD School of Medicine) and Ph.D. training in areas of the biomedical sciences, including cellular and molecular biology, neuroscience, and bioengineering. Excellent trainees are recruited throughout the United States and graduates typically pursue careers as academic physician scientists. This MSTP has evolved through not only expanding research opportunities and support at UCSD and affiliated institutions (Salk Institute for Biological Sciences and the Scripps Research Institute) but also growing a pool of diverse, high quality applicants and faculty.

PI_NAMEs: CHI, NEIL C;INSEL, PAUL A (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative In this supplement application, we are requesting funds to purchase a Monolith X (Nano Temper Technologies) microscale thermophoresis instrument. This equipment will be used to determine the binding affinity (KD) in various protein-protein, protein-nucleic acid, and protein-small molecule interactions, which is critical in the proposed structural studies of viral replication and invasion.

PI_NAMEs: AIHARA, HIDEKI  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affinity;Antibodies;antiviral drug development;Area;Binding;Cells;Chromosomes;Complex;Coronavirus;Coronavirus spike protein;Emerging Technologies;Equipment;Exoribonucleases;Funding;Gene Delivery;gene therapy;Genome;Health;Human;human pathogen;Human T-Cell Leukemia Viruses;instrument;Integration Host Factors;interest;Invaded;Laboratories;Life Cycle Stages;Molecular;nano;novel;Nucleic Acids;programs;Proteins;receptor binding;Receptor Inhibition;Research;Retroviridae;RNA;Role;Rous sarcoma virus;small molecule;structural biology;Techniques;Technology;Thermodynamics;tool;Viral;Viral Genome;Viral Reverse Transcription;Virus;Virus Replication

PROJECT_TITLE: Structural studies of viral replication and invasion


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MENLO PARK

ORG_NAME: VCREATE, INC.

PI_NAMEs: CHEN, BINBIN  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Algorithms;Alleles;antigen binding;Antigens;Atlases;Autoantigens;Award;Bar Codes;bioinformatics pipeline;CD8-Positive T-Lymphocytes;cell killing;Cell Line;Cells;Cellular Assay;Child;Childhood Acute Myeloid Leukemia;combat;comparison control;Complex;Data;Databases;Diagnosis;DNA;drug candidate;Engineering;Ensure;experimental study;flexibility;Genomics;HLA-A1 Antigen;HLA-A2 Antigen;HLA-A3 Antigen;Human;In Vitro;Interferon Type II;K-562;lentivirally transduced;Lentivirus;leukemia relapse;Libraries;Ligands;Literature;Machine Learning;MAGEA3 gene;Malignant Neoplasms;Measures;Membrane;Methods;MHC antigen;Mining;Mutation;Myeloid Cells;novel;nuclear factors of activated T-cells;Patients;Peptides;preferentially expressed antigen in melanoma;promoter;Property;Proteins;red fluorescent protein;Reporter;Resolution;screening;single cell analysis;single cell sequencing;Small Business Innovation Research Grant;Sorting;statistics;stem cell technology;success;Surface;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Tissues;Validation;Viral Antigens

PROJECT_TITLE: CONCEPT SBIR - T-CELL RECEPTORS FOR TREATING PEDIATRIC ACUTE MYELOID LEUKEMIA


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE (R35 GM124824) Acidic environment is crucial for the function of many intracellular organelles, and is also one of the pathological hallmarks of various diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. This proposed research program will focus on a new family of acid receptor: how its activity is regulated and what role it plays in physiology and disease.

PI_NAMEs: QIU, ZHAOZHU  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acidosis;Acids;Animals;Anions;Area;Biology;Calcium Channel;Cell Death Induction;cell injury;Cell Volumes;Cells;Cerebral Ischemia;Chloride Channels;Chlorides;Cryoelectron Microscopy;Cystic Fibrosis;Disease;Drug Targeting;Electrophysiology (science);Environment;Epilepsy;Family;Fluids and Secretions;Functional disorder;functional genomics;Funding;Genetic Diseases;Goals;imaging genetics;In Vitro;in vivo;Infection;Inflammation;interdisciplinary approach;Ion Channel;Ions;Ischemic Brain Injury;Knockout Mice;Malignant Neoplasms;Mediating;Membrane Proteins;Molecular;Molecular Conformation;mouse genetics;Mutagenesis;Myocardial Ischemia;Myotonia;novel;Organelles;patch clamp;Pathologic;Pathway interactions;Physiological;Physiology;Play;Potassium Channel;programs;Protons;receptor;Regulation;Research;RNA interference screen;Role;Sodium Channel;Stroke;structural biology;Swelling;Time

PROJECT_TITLE: Molecular Identity and Physiological Function of Novel Chloride Channels


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Project Narrative Faithful segregation of chromosomes underlies genome integrity in all organisms. My R01GM141242 project aims to identify the mechanisms by which broadly conserved structural maintenance of chromosomes (SMC) complexes organize and compact replicated chromosomes in the cell. In this supplement proposal, I am requesting funds to purchase an AKTA pure 25 M Chromatography System and necessary accessories to perform in vitro biochemical experiments proposed in Aim 2.

PI_NAMEs: WANG, XINDAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Administrative Supplement;Bacteria;Biochemical;Biological Assay;Cell Cycle;Cells;Chromatography;chromosome replication;Chromosome Segregation;Chromosome Structures;Chromosomes;Complex;condensin;Cytology;DNA;Equipment;experimental study;Funding;Genetic;genome integrity;Goals;Grant;Human;In Vitro;Maintenance;Methods;Molecular;Organism;parent grant;protein protein interaction;protein purification;Proteins;Research;segregation;System

PROJECT_TITLE: How bacterial SMC complexes organize chromosomes

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Gene Therapy;Genetics;Health Services;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed and refractory hematologic malignancies; however, the immunologic impact and risk for infections and mortality following treatment have not been well-characterized. This Career Development Award focuses on applying advanced clinical epidemiology and simulation modeling to understand the immunologic impact of CAR T-cell therapy. Our overall objective is to identify predictive risk factors and cost-effective screening methods to allow for risk stratification, protocols for immunologic monitoring, and initiation of earlier interventions to mitigate the risk for morbidity and mortality and improve quality of life.

PI_NAMEs: BARMETTLER, SARA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adult;Age;Antibodies;B cell therapy;B-Lymphocytes;Bayesian Analysis;Biometry;cancer diagnosis;CAR T cell therapy;career;career development;CD19 gene;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical epidemiology;Clinical Research;clinical risk;clinically significant;cohort;Communicable Diseases;comorbidity;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Coupled;cytokine release syndrome;Data;Development;Diagnosis;Dose;Early identification;Early Intervention;Education;Environment;Epidemiology;experience;FDA approved;Frequencies;Future;General Hospitals;Goals;Health;Health Care Costs;Healthcare Systems;Hematologic Neoplasms;high risk;Hypersensitivity;hypogammaglobulinemia;Immune;Immune System Diseases;immunodeficiency;Immunoglobulins;Immunologic Monitoring;Immunologics;Immunology;Immunomodulators;Immunophenotyping;improved;improved outcome;Infection;infection risk;instructor;International;Intervention;K-Series Research Career Programs;Knowledge;Leadership;Life;longitudinal analysis;Lymphopenia;Malignant - descriptor;Malignant Neoplasms;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;Outcome;Outcome Measure;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Pediatric cohort;Peripheral;Physicians;Population;Productivity;professor;prospective;Protocols documentation;Quality of life;Questionnaires;receptor;Recommendation;Refractory;Relapse;Replacement Therapy;Research;Research Personnel;Research Proposals;Research Training;responsible research conduct;Retrospective cohort;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;risk stratification;rituximab;Scientist;screening;Serum;Severities;sex;skills;success;Surface Antigens;Techniques;therapeutic target;Training;Training Programs;tumor;Tx receptor;Work

PROJECT_TITLE: Modeling Risk for Hypogammaglobulinemia, Infections, and Mortality with Chimeric Antigen Receptor (CAR) T-cell Therapy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Precision Medicine

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The accumulation of hidden genetic variants over generations potentially represents a mechanism by which complex multigenic traits can be suddenly revealed in response to environmental challenge. This proposal aims to use the natural case of eye variation in the blind cavefish, Astyanax mexicanus, as a model for vertebrate cryptic variation. By leveraging the strength of systematic analysis in the zebrafish, we will dissect out the specific molecular mechanism by which the chaperone molecule, Hsp90, buffers cryptic variants that contributed to the evolution of eye-loss in the Astyanax cavefish.

PI_NAMEs: GRUNWALD, HANNAH ARIEL (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Acceleration;Acute;Affect;Age;Alleles;blind;Body System;Buffers;Candidate Disease Gene;Chromatin;Client;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Disease;Dominant-Negative Mutation;Electric Capacitance;Environment;Evolution;Experimental Designs;experimental study;Eye;Eye Development;Eye diseases;Family;Fishes;fly;Foundations;Generations;Genes;Genetic;Genetic Counseling;Genetic Determinism;Genetic Diseases;Genetic Models;Genetic Screening;genetic variant;Genetic Variation;genomic data;Genomic Segment;genomic variation;Genomics;Genotype;Heritability;HSP 90 inhibition;in vivo;Individual;inhibitor;insight;Knock-out;knockout gene;Laboratories;lens;Life Cycle Stages;Mediating;Modeling;Molecular;Molecular Chaperones;Morphology;mutant;Mutation;novel;Pathway interactions;Penetrance;personalized medicine;Phase;Phenotype;Phosphotransferases;Plants;Population;precision genetics;Predisposition;Prevalence;Proteins;Proteomics;proteotoxicity;Recording of previous events;Research;response;Role;Running;sample fixation;Severities;Signal Transduction;Speed;Stereotyping;Stress;success;Surface;System;teleost;Testing;Tissues;tool;Training;trait;Transducers;Variant;Water;Work;Yeasts;Zebrafish

PROJECT_TITLE: Unraveling the role of molecular capacitors that obscure cryptic genetic variation in Astyanax mexicanus during the evolution of eye loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (MK)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Post-translational modifications of histones and transcription factors are critical to gene function and misregulated in several diseases. We are developing chemical strategies to investigate the biophysical and biochemical effects of histone sumoylation and p53 methylation in human chromatin. Our studies will reveal new mechanisms underlying chromatin regulation and provide new therapeutic targets in diseases arising from its misregulation.

PI_NAMEs: CHATTERJEE, CHAMPAK  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Administrative Supplement;Amino Acids;Biochemical;Biophysics;Chemicals;Chromatin;Coupling;design;Disease;Ensure;Excision;Fiber Optics;Freedom;gene function;histone modification;Histones;Human;Malignant Neoplasms;Manuals;Methylation;microwave electromagnetic radiation;Modification;Monitor;Neoplasms;new therapeutic target;novel;Pathway interactions;Peptide Fragments;Peptide Synthesis;Peptides;Phase;Post-Translational Protein Processing;Reaction;Regulation;seal;Site;Solid;Sumoylation Pathway;Temperature;TP53 gene;transcription factor;wasting

PROJECT_TITLE: Chemical strategies to investigate biochemical crosstalk in human chromatin


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Patients with inherited bone marrow failure syndromes have significant morbidity and mortality due to complications of aplasia and myelodysplasia. These patients have no curative options other than hematopoietic stem cell transplant and no proven medical therapies are available. This proposal aims to determine which patients with inherited bone marrow failure will develop hematopoietic complications and identify a specific therapeutic target for these disorders.

PI_NAMEs: KENNEDY, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Academic Training;Address;Alleles;Architecture;Award;Bar Codes;Binding;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Boston;Bypass;Cancer Hospital;career development;Catalysis;Cells;Cellular Stress;Childhood;Clinical;Clonal Evolution;cohort;Computational Biology;curative treatments;Data;Defect;design;Development Plans;Diagnosis;Disease;DNA;DNA sequencing;Dysmyelopoietic Syndromes;Excision;experimental study;Fibroblasts;fitness;Functional disorder;Gene Dosage;Genes;Genetic Predisposition to Disease;genetic risk factor;genomic data;Genomics;Genotype;Germ Lines;Grant;Guanosine Triphosphate Phosphohydrolases;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Immunophenotyping;improved;in vitro Model;Inherited;Inherited bone marrow failure;innovation;insight;Institution;Laboratories;Lead;Leadership;Location;loss of function;loss of function mutation;Marrow;Mediating;Medical;medical schools;Mentors;Missense Mutation;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;new therapeutic target;novel;Outcome;Pathway interactions;Patients;Pediatric Hospitals;Phenotype;Physicians;Predisposition;Prognosis;Proteins;Proteomics;rational design;Recurrence;Reporting;Research;Ribosomes;Sampling;Scientist;Shwachman-Diamond syndrome;skills;Somatic Mutation;Stress;Syndrome;Testing;Therapeutic;therapeutic target;Time;TP53 gene;Training;Translating;Translations;treatment strategy;Writing;young adult

PROJECT_TITLE: Insights from somatic genomics lead to novel therapeutic targets in inherited bone marrow failure syndromes: Shwachman-Diamond Syndrome as a model

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Anastasis is a newly discovered cell recovery phenomenon that enables dying cells to survive by reversing the apoptotic cell death process. The mechanisms and consequences of anastasis remain unclear. By developing a biosensor to detect anastasis in live animals, and identifying key regulators of anastasis, our project will develop critical tools and knowledge to study the physiological, pathological, and therapeutic implications of anastasis.

PI_NAMEs: TANG, HO LAM  (contact)

PROJECT_TERMS: Animals;Apoptosis;Apoptotic;Biosensor;Brain Injuries;cancer cell;Cancer cell line;cancer survival;cancer therapy;Cardiac Myocytes;Cell Death;Cell Death Induction;Cell Death Process;Cell Differentiation process;Cell Survival;Cells;Cessation of life;clinically relevant;confocal imaging;Cytoprotection;Drosophila genus;efficacy evaluation;egg;Embryonic Development;Exhibits;Foundations;Genes;Genetic;Heart failure;Homeostasis;Human;In Vitro;in vivo;insight;Knowledge;Label;Mammalian Cell;Molecular;Morphology;mouse model;Mus;Neurons;novel;novel therapeutic intervention;Pathologic;pharmacologic;Physiological;Play;Post-Translational Protein Processing;preservation;Proteins;Proteomics;Rattus;Recovery;Recurrence;Recurrent disease;Regulation;Role;stable cell line;System;targeted agent;Testing;Therapeutic;therapeutic target;Tissues;tool;Xenograft procedure

PROJECT_TITLE: Anastasis: A Novel Cell Survival Mechanism


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pain Research;Prevention;Serious Mental Illness;Suicide

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Rising suicide fatality rates in the US underscore the need to identify novel and effective therapeutic targets for suicide risk, beyond existing monoamine-focused treatments such as antidepressants. Evidence suggests that glutamatergic neurotransmission is important to the pathophysiology of suicide. This project will assess alterations in brain glutamatergic signaling both at rest and during task-related activity in depressed individuals at risk for suicidal behavior.

PI_NAMEs: HERZOG, SARAH  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adaptive Behaviors;Affect;Affective;Amino Acid Neurotransmitters;anti-depressive agents;Attention;Attenuated;Autopsy;base;Behavior;behavioral response;Biomedical Engineering;Brain;Brain region;Cessation of life;clinical risk;Cognition;Cognitive;cognitive task;Collaborations;Complex;Depressed mood;design;Development;Ecological momentary assessment;emotion dysregulation;Etiology;Evaluation;Executive Dysfunction;executive function;Exhibits;experience;Fatality rate;Feeling suicidal;Functional disorder;Genetic;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Growth;healthy volunteer;Hydrocortisone;Image;in vivo;in vivo magnetic resonance spectroscopy;Individual;innovation;Ketamine;Learning;Length;Life;Link;Magnetic Resonance Spectroscopy;Measurement;Measures;Mediating;Mental Depression;Metabolic;monoamine;mood symptom;Moods;N-Methylaspartate;negative affect;neurochemistry;Neurocognitive;neurotransmission;novel;Pain;Pain Threshold;Participant;Pathogenesis;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiological;Population;Prefrontal Cortex;premature;Protons;receptor function;Recording of previous events;Regulation;Reporting;Research;Research Design;response;Rest;Risk;Risk Factors;Role;Salivary;Scanning;Signal Transduction;spectroscopic imaging;Spectrum Analysis;Stress;stress reactivity;stressor;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Synaptic plasticity;Therapeutic;therapeutic target;therapeutically effective;Time;transmission process;United States;Volunteer Group;Work

PROJECT_TITLE: Resting and Dynamic Brain Glutamate by MRS In Vivo: Relation to Suicidal Behavior

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative All living organisms produce and release small extracellular vesicles. In humans, they have been implicated in cell-to-cell communication and pathological conditions such as neurodegenerative and cardiovascular diseases and cancer progression. This project seeks to acquire a device to measure size, amount, and surface properties of extracellular vesicles and other types of small nanoparticles. The device is a critical tool for researchers using the presence of extracellular vesicles as a diagnostic indicator for disease and co-opting extracellular vesicles or synthetic nanoparticles to deliver therapeutics.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: bioimaging;Bone Marrow Cells;cancer cell;Cardiovascular Diseases;Cell Communication;Cells;Complement;Core Facility;Delaware;Devices;Diagnostic;Disease;Disease Progression;Drug Delivery Systems;Drug usage;Electron Microscopy;Ensure;extracellular vesicles;Fee-for-Service Plans;Flow Cytometry;Human;imaging facilities;Individual;Investments;Measures;nanoparticle;nanovesicle;Neurodegenerative Disorders;Organism;parent grant;particle;pathogenic microbe;Pathologic;Peptides;Research Personnel;Research Support;Running;Sampling;Scientist;Services;Surface Properties;Systems Analysis;Technology;Therapeutic;tool;Training;tumor progression;Universities;Vesicle;vesicular release;Virus;Virus-like particle;zeta potential

PROJECT_TITLE: Delaware INBRE


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Opioids;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Substance Misuse;Substance Misuse Prevention

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE There is an urgent need to develop an effective universal overdose prevention intervention for youth given rising overdose deaths for youth, and the risks associated with fentanyl and other emerging drugs in the drug supply. Primary care providers provide anticipatory guidance for injury prevention to youth as part of annual physical exams and are therefore well positioned to deliver a universal overdose prevention intervention. An effective universal overdose prevention intervention will directly benefit youth by decreasing their risk, and will benefit public health generally as they will be more prepared to recognize and respond to others who have an overdose.

PI_NAMEs: BAGLEY, SARAH M (contact);YULE, AMY

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adolescent and Young Adult;Adolescent Risk Behavior;adolescent substance use;Adult;Age;aged;arm;Awareness;Behavioral;Benzodiazepines;Boston;Cessation of life;Childhood;Collaborations;Communities;community advisory board;community engagement;Conduct Clinical Trials;Control Groups;cost effective;Counseling;Data;Death Rate;design;Development;Drowning;Drug usage;efficacy evaluation;Ensure;evidence base;Exclusion Criteria;experience;Exposure to;Family;Family Practice;Fentanyl;Firearms;follow-up;group intervention;Health Benefit;health care settings;Health Personnel;Home;improved;Individual;Injury;injury prevention;Intervention;Knowledge;Learning;manufacture;Measures;Medical center;Modeling;Motivation;Naloxone;novel;opioid use;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;pediatrician;Pharmaceutical Preparations;pill;pilot trial;polysubstance use;Positioning Attribute;Prevention;Prevention education;preventive intervention;Primary Care;primary care provider;primary care setting;primary outcome;Procedures;Provider;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Readiness;Recommendation;Recording of previous events;response;Risk;Risk Reduction;Safety;Science;secondary outcome;skills;standard of care;Stimulant;Testing;therapy development;Time;Translating;Treatment Efficacy;trial design;Trust;United States;years of life lost;Youth

PROJECT_TITLE: A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: This is a request for an equipment supplement on award R35GM142763.

PI_NAMEs: DU, KE  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: Administrative Supplement for a Basic 3D-microfabrication System with Piezo 100 microns - MicroFAB-3D.B


NIH_SPENDING_CATS: Natural Products

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative  Our study will investigate the structure and function of emerging PLP-dependent enzymes, discover new PLP-dependent enzymes through genome mining, and elucidate the natural product biosynthetic pathways involving PLP-dependent enzymes with potential novel functions. Our work will not only increase our knowledge of PLP enzymology, but also expand the biocatalytic toolbox for the biocatalytic synthesis of pharmaceutically important noncanonical amino acid building blocks.

PI_NAMEs: HAI, YANG  (contact)

PROJECT_TERMS: Amines;Amino Acids;aminoacid biosynthesis;bioactive natural products;Biology;Carbon;Cell Physiology;Chemicals;Complex;Data;Enzymatic Biochemistry;Enzymes;Family;frontier;Funding;Genome;Goals;Investigation;Knowledge;Laboratories;Metabolism;Mining;Natural Products;Nature;non-Native;novel;parent grant;Pathway interactions;Pharmacologic Substance;Play;programs;Research;Role;Specificity;Structure;Substrate Specificity;Therapeutic;tool;Work

PROJECT_TITLE: Understanding the specificity and non-native catalytic activity of PLP-dependent enzymes


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding the mechanisms that regulate eukaryotic proteasome assembly, which is critical in many diseases. Once such knowledge is established, there is the potential for a significant advance in new therapies for patients targeting the proteasome. Thus, the current interdisciplinary proposal is relevant to the part of the NIH’s mission that pertains to reducing illness.

PI_NAMEs: LAGUNES, LEONILA  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: 26S proteasome;Alzheimer's Disease;Behavior;Binding;Biochemistry;Biological Models;Biological Sciences;Cell Communication;Cell Survival;Cells;clinical application;Complex;Computational Biology;Data;Development;Disease;dynamic system;Environment;Eukaryota;Eukaryotic Cell;Event;experimental analysis;Feedback;Fellowship;Future;Gene Expression;Goals;Growth;Health;human disease;inhibitor;innovation;Innovative Therapy;insight;Institution;Investigation;Kinetics;Knowledge;Lead;Malignant Neoplasms;MAP Kinase Gene;mathematical model;Mediating;Mentors;Methods;Mission;model organism;Modeling;Molecular Chaperones;Molecular Conformation;Molecular Machines;multicatalytic endopeptidase complex;novel;novel therapeutics;Nucleosome Core Particle;Outcome;particle;Pathway interactions;Patients;Phase;Phosphorylation;Phosphorylation Site;Phosphotransferases;Positioning Attribute;Post-Translational Protein Processing;Process;Proteins;proteostasis;Public Health;Regulation;Research;Research Personnel;response;Signal Transduction;Site;System;Testing;Theoretical model;Training;transcription factor;Transcription Initiation;Translating;Translations;United States National Institutes of Health;Update;Yeasts

PROJECT_TITLE: Understanding eukaryotic proteasome assembly regulation


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: Comorbid Childhood Apraxia of Speech (CAS), a motor speech disorder affecting speech movement planning, may be one factor limiting the ability of some minimally verbal children with autism to acquire spoken language. This project aims to identify a cohort of minimally verbal children who meet criteria for autism and CAS and, using kinematic analysis of speech, to quantify how CAS affects speech movement consistency and precision. The relationship of speech movement parameters, intelligibility, and signs of CAS will be investigated in order to identify movements that are both disordered and intelligibility-reducing. These procedures will be used to create a set of mono- and bisyllabic stimuli, unique to each participant, that can reveal whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.

PI_NAMEs: CHENAUSKY, KAREN V (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Affect;Age;Aggressive behavior;Area;Auditory;autism spectrum disorder;autistic children;Characteristics;Child;Clinical;clinical practice;Clinical Research;clinical translation;cohort;comorbidity;Cues;Data;Development;Developmental apraxia;Diagnosis;Disease;effectiveness evaluation;experimental study;Face;Goals;Impairment;improved;innovation;Intervention;Investigation;kinematics;Language;language outcome;Leadership;Mentorship;Methods;minimally verbal;Motor;motor control;motor learning;Movement;movement analysis;Movement Disorders;neuromuscular;novel;Outcome Measure;Output;Participant;phonology;Population;Procedures;Production;Research;Self-Injurious Behavior;Series;Severities;Speech;Speech Disorders;Speech Intelligibility;Stimulus;System;Tactile;Target Populations;targeted treatment;Testing;Training;Work

PROJECT_TITLE: Identifying and Treating Childhood Apraxia of Speech in Minimally Verbal Children with Autism

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Narrative During the critical search for drugs to treat COVID-19 patients, it’s important to select drugs with maximum antiviral efficacy and minimal side-effects. Using a combination of computer modeling and animal studies, we will test the potential for COVID-19 therapies to cause hearing loss; a side-effect of many drugs not often detected during clinical trials. Our goal is to help develop safer COVID-19 therapies.

PI_NAMEs: COFFIN, ALLISON B (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Adult;Animals;anti-viral efficacy;Auditory;Azithromycin;Biological Assay;Biometry;Blood;Case Study;Categories;Cause of Death;Chemical Structure;Clinical;Clinical Trials;Cochlea;combat;Computer Models;computer scientist;cost;COVID-19;COVID-19 patient;COVID-19 screening;COVID-19 therapeutics;COVID-19 treatment;cytotoxic;cytotoxicity;Data;Data Set;Databases;Detection;Development;Disease;drug candidate;Drug Combinations;drug development;Drug usage;experimental study;FDA approved;feature selection;Goals;Hair Cells;hearing impairment;Hearing Tests;Human;Human Resources;Hydroxychloroquine;Immune response;Immune system;in silico;In Vitro;in vivo;Individual;Infection;Inner Hair Cells;innovation;Intervention;Ivermectin;Labyrinth;lateral line;Life;Link;Machine Learning;machine learning model;Methods;Modeling;Molecular;Monitor;Morphology;novel;novel therapeutics;older patient;Organ;otoprotectant;ototoxicity;ototoxin;pandemic disease;Patient Monitoring;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Physiological;Physiology;Positioning Attribute;pre-clinical;Preclinical Testing;preservation;Principal Component Analysis;Public Health;Publishing;rapid detection;Rattus;Reporting;Research;research clinical testing;response;Risk;Ritonavir;screening;Sensory;Sensory Hair;severe COVID-19;side effect;Stavudine;Supporting Cell;Synapses;System;systemic inflammatory response;Testing;Therapeutic;Therapeutic Uses;Toxic effect;training data;Treatment Efficacy;Vaccination;Work;Zebrafish

PROJECT_TITLE: Determining the ototoxic potential of COVID-19 therapeutics using machine learning and in vivo approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Childhood obesity is a major public health concern, particularly among Latino and Black children, who experience a disproportionate burden, compared to white children. The proposed research is focused on understanding the impacts of vertical microbiome transmission on childhood overweight and obesity outcomes in Latino and Black populations. Understanding the role that vertical microbiome transmission plays in the development of childhood obesity may have far-reaching public health implications and is critical for developing novel interventions and therapies to prevent childhood obesity.

PI_NAMEs: HOLZHAUSEN, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: 2 year old;3 year old;Adipose tissue;Advisory Committees;African American;Age Months;American;Antibiotics;beta diversity;Bioinformatics;Birth;Black Populations;Black race;Body mass index;Body System;Breast Feeding;career;Cesarean section;Child;Childhood;Circulation;cohort;Complement;Data;design;Development;Diet;Ensure;Environment;Etiology;Event;experience;fecal metabolome;Food;Genes;Goals;Growth;gut microbes;gut microbiome;Human Milk;improved;infancy;Infant;infant gut microbiome;Inflammation;Instruction;Intervention;Investigation;Knowledge;Late pregnancy;Latino;Latino Population;Life;Life Cycle Stages;Link;Longitudinal Studies;maternal microbiome;maternal weight;Measures;Metabolic;metabolome;metabolomics;metagenomic sequencing;Microbe;microbiome;microbiome alteration;microbiome analysis;Mothers;Multiomic Data;multiple omics;novel;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;overweight child;Pathway Analysis;Pathway interactions;Pattern;phenotypic data;Play;Positioning Attribute;Postpartum Period;Pregnancy;Premature Birth;prepregnancy;prevent;Prevention strategy;Production;prospective;Public Health;R24;rapid growth;Research;Research Personnel;Resources;Ribosomal RNA;Risk;Role;skills;social culture;Solid;stool sample;Subgroup;Techniques;therapeutic target;Time;Training;transmission process;Vagina;Vaginal delivery procedure;Vertical Transmission;Visit;Weight;Weight Gain;Work

PROJECT_TITLE: Vertical Microbiome Transmission: Implications for Infant Growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Nager syndrome (OMIM#154400) is a developmental disorder characterized by hypoplasia of the facial bones and a variety of limb defects. Mutations in the SF3B4 gene, which encodes a protein involved in the maturation of pre-mRNA, is a major cause for Nager syndrome. In this application I propose to gain novel insights into the mechanisms underlying Nager syndrome craniofacial defects through in vivo and in vitro modeling of the disease, and carry that knowledge over to the modeling of other craniofacial disorders to determine if there is a common root cause.

PI_NAMEs: GRIFFIN, CASEY  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;Animals;Apoptosis;Apoptotic;Automobile Driving;Binding;Biological;Biological Process;Bone structure;Candidate Disease Gene;candidate validation;Categories;Cell Death;Cell Line;Cell Migration Pathway;cell motility;cell type;Cells;Cephalic;Chondrocytes;Classification;Cleft Palate;Clinical;Collaborations;Complex;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;craniofacial disorder;craniofacial microsomia;CRISPR/Cas technology;Data;Defect;Development;developmental disease;Disease;disease model;Embryo;Event;experience;experimental study;face bone structure;gain of function;Gene Expression;Genes;Genetic Transcription;Head;human embryonic stem cell;immunocytochemistry;In Situ Hybridization;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;insight;Introns;Joining Exons;knock-down;Knowledge;Limb structure;loss of function;Maintenance;malformation;Mandibulofacial Dysostosis;Mediating;melanocyte;Messenger RNA;Micrognathism;Modeling;Molecular;mRNA Precursor;mutant;Mutation;Nager syndrome;Neural Crest;Neural Crest Cell;Neuronal Differentiation;Neurons;novel;Online Mendelian Inheritance In Man;Ontology;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;Phenotype;premature;Production;protein function;Proteins;Quantitative Reverse Transcriptase PCR;Radial;rare condition;RNA;RNA Splicing;Role;Skeleton;Small Interfering RNA;Specificity;Spliceosomes;stem cells;Syndrome;Testing;Thumb structure;Tissues;transcriptome sequencing;transcriptomics;Translating;Variant;Work;Xenopus

PROJECT_TITLE: Deciphering the underlying mechanisms of craniofacial spliceosomopathies

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Nutrition;Obesity;Sepsis

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative While obesity accounts for over 50% of septic surgical patients and is independently associated with 90-day mortality, the mechanism underlying how obesity modulates sepsis outcomes is lacking, particularly in surgical patients. This proposal will integrate mechanistic in vitro studies with sophisticated murine modeling of obesity and intra-abdominal sepsis to provide crucial data on possible therapeutic targets to mitigate the disparities in mortality between obese and non-obese septic surgical patients. This proposal has the potential to deliver fundamental insight into disease regulation and novel therapeutics to optimize sepsis management in a highly relevant clinical patient population.

PI_NAMEs: JALILVAND, ANAHITA  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Adipocytes;Adipose tissue;Admission activity;Applications Grants;Area;Award;bactericide;bariatric surgery;Basic Science;Behavior;Biology;career development;cecal ligation puncture;Cell Communication;Cells;Chemotaxis;clinically relevant;comorbidity;Data;Development Plans;diet-induced obesity;Disease;Disparity;disparity reduction;Doctor of Philosophy;Down-Regulation;Event;extracellular vesicles;Foundations;Funding;Gene Targeting;Goals;Harvest;High Fat Diet;Human;Immune;immune function;Immunologics;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;insight;Institution;Intensive Care Units;interdisciplinary approach;Intra-abdominal;K-Series Research Career Programs;Knock-out;Laboratories;live cell imaging;Mediating;Mediator;Mentors;Mentorship;Metabolic;microRNA delivery;MicroRNAs;migration;Modeling;mortality;mortality disparity;mouse model;Mus;neutrophil;new technology;Non obese;novel;novel therapeutics;Obese Mice;obese patients;Obesity;Operative Surgical Procedures;Outcome;pathogen;Pathway interactions;patient population;Patients;Peripheral;pharmacologic;Phosphatidylinositols;Phosphotransferases;Prevalence;Production;Reactive Oxygen Species;Regulation;Research;research and development;Research Proposals;Resources;response;Role;Scientist;Sepsis;septic;septic patients;success;Surgeon;Techniques;Technology;Testing;therapeutic target;Thinness;Time;Training;transcriptomic profiling;Transfection;Transgenic Organisms;Up-Regulation;Visceral

PROJECT_TITLE: The impact of obesity on neutrophil swarming in septic surgical patients

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative Protein arginylation is increasingly recognized as a global biological regulator essential for physiological processes, including angiogenesis, embryogenesis, aging, and cell migration. ATE1 is the sole enzyme responsible for protein arginylation and has recently been implicated in human cancers and neurodegenerative diseases, but its catalytic mechanism and regulation remain poorly understood. This project aims to understand the structural, catalytic, and regulatory mechanisms of protein arginylation, which may lead to new therapeutic strategies for preventing the development and progression of Parkinson’s disease and Metastatic Cancer.

PI_NAMEs: ZHANG, YI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Aging;Amino Acids;Aminoacylation;angiogenesis;Arginine;Autophagocytosis;Autophagosome;Biochemical;Biological;biological adaptation to stress;biophysical techniques;cell motility;Cell Physiology;Cells;cofactor;Degradation Pathway;Development;Disseminated Malignant Neoplasm;Embryonic Development;Enzymes;Event;Human;In Vitro;Kinetics;Knowledge;macromolecule;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Modeling;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;novel therapeutic intervention;Nutrient;Parkinson Disease;Pathway interactions;Patients;Physiological Processes;Polyubiquitination;Post-Translational Protein Processing;prevent;Protein Biosynthesis;protein degradation;Proteins;Reaction;Regulation;Research;Ribosomes;Role;Shapes;Site;Skin Cancer;Stress;Transfer RNA;Transfer RNA Aminoacylation;Transferase;Translations;Ubiquitination

PROJECT_TITLE: Arginyl-tRNA beyond translation: mechanism and regulation of protein arginylation


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE The LetA family of lipid transporters are conserved across Gram-negative and certain eukaryotes, such as Plasmodium falciparum. However, the cellular role of this protein family remains unclear. This research proposal aims to elucidate the structure and function of LetA proteins from various species, providing valuable insights into the cellular role of a conserved mechanism of lipid transport.

PI_NAMEs: SANTAROSSA, CRISTINA  (contact)

PROJECT_TERMS: Address;aqueous;Architecture;Award;Bacteria;bacterial genetics;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Blood;career;career development;Cell membrane;Cell Physiology;Cells;Cellular Assay;Cellular biology;Chloroplasts;Code;Communication;Communities;Complex;Cryoelectron Microscopy;Detergents;Development Plans;Environment;Escherichia coli;Escherichia coli Proteins;Essential Genes;Eukaryota;Faculty;Family;Fatty Acids;Genes;Genetic;Goals;Gram-Negative Bacteria;Grant;Home;Hydrophobicity;insight;Klebsiella pneumoniae;Life;lipid transport;lipidomics;Lipids;Malaria;marine;Mass Spectrum Analysis;Mediating;member;Membrane;Mentors;Microbiology;Missense Mutation;Mitochondria;Movement;multidisciplinary;mutant;Organelles;Outcome;outreach;Parasites;Pathway interactions;periplasm;Permeability;Phase;Physiological;Plasmodium falciparum;Plastids;Positioning Attribute;post-doctoral training;Principal Investigator;Process;Professional Competence;programs;Protein Family;Proteins;recruit;Research;research and development;Research Proposals;Resistance;Resolution;Role;Science;skills;structural biology;Structure;student retention;Substrate Specificity;System;Techniques;tenure track;Testing;therapeutic target;Training;Underrepresented Students;Universities;Variant;Writing

PROJECT_TITLE: Structure and function of the LetA lipid transport family across bacteria and eukaryotes


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Pediatric;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Underage Drinking

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance Statement Project Narrative: Adolescents with a chronic medical condition (A-CMC) have high rates of risky drinking and drug use and account for the majority of pediatric inpatient hospitalizations. However, A-CMCs are not routinely screened for alcohol use in pediatric inpatient settings, highlighting a major missed opportunity. This mentored research proposal will facilitate the implementation of SBIRT in inpatient units within a large urban pediatric hospital, while providing preliminary data to inform the development of a highly scalable approach that can be used in pediatric hospitals across the country.

PI_NAMEs: SUMMERSETT WILLIAMS, FAITH  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Accident and Emergency department;Accidents;Activities of Daily Living;Acute;Address;Administrator;Admission activity;Adolescent;adolescent alcohol and drug use;adolescent health;Adoption;Age;aged;alcohol and other drug;Alcohol consumption;alcohol screening;alcohol use initiation;Alcohols;Area;arm;behavioral health;Biological Models;career;career development;Caregivers;Caring;Cessation of life;Chicago;Childhood;Chronic;Clinical;cohort;Collaborations;Complex;Country;Data;design;Development;Development Plans;Diagnosis;Disease;disorder control;drinking;Drug usage;Early Intervention;effectiveness outcome;effectiveness/implementation trial;Electronic Health Record;Emergency department visit;Equity;Ethics;evidence base;experience;Family;field study;Foundations;Funding;Goals;Health;Health Services;Health system;Healthcare Systems;high risk drinking;Hospitalization;Hospitals;Human;Hybrids;implementation determinants;implementation evaluation;implementation facilitation;implementation facilitators;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;Information Technology;inpatient service;Inpatients;Intervention;Knowledge;Learning;Medical;medical attention;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;misuse of prescription only drugs;Outcome;Parents;Patients;pediatric emergency;Pediatric Hospitals;Performance;Pharmaceutical Preparations;Population;prevent;primary outcome;Process;Public Health;public health relevance;Recommendation;Research;research and development;Research Proposals;Risk;Scientist;screening;screening, brief intervention, referral, and treatment;secondary outcome;Specific qualifier value;Taxonomy;Techniques;Testing;theories;Time;Training;underage drinking;United States;United States Agency for Healthcare Research and Quality;uptake;usability;Work

PROJECT_TITLE: Adaptation and Implementation of SBIRT for Adolescents with Chronic Medical Conditions Hospitalized in Pediatric Inpatient Units

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Reducing the incidence of devastating birth defects requires a mechanistic understanding of cell signaling and force transmission in developing tissues. My lab uses Drosophila to investigate force generation by the actomyosin cytoskeleton and its regulation within cells and across tissues. These studies will provide insight into the interplay between contractile signaling and force generation, providing a framework for understanding emergent tissue shapes.

PI_NAMEs: MARTIN, ADAM CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Actomyosin;Affect;Behavior;Biological;cell behavior;Cells;Complex;Congenital Abnormality;Cytoplasm;Cytoskeleton;Development;Drosophila genus;Engineering;Epithelium;Exhibits;gastrulation;Generations;Germ Lines;Goals;Guanosine Triphosphate Phosphohydrolases;Incidence;insight;Link;Mathematics;Mechanics;member;Molecular;Morphogenesis;Movement;multidisciplinary;Oocytes;Oogenesis;Pattern;Physiologic pulse;Regulation;Research;response;rho GTP-Binding Proteins;rho GTPase-activating protein;Role;Shapes;Signal Pathway;Signal Transduction;Supporting Cell;Tissues;transmission process;Visualization;Work

PROJECT_TITLE: Tissue morphogenesis: From signals to forces


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative It is estimated that 10-25% of human embryos have the wrong number of chromosomes, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of mistakes generated when female reproductive cells (oocytes) divide, yet surprisingly little is known about the mechanisms that underlie the vulnerability of oocytes to these errors. This project seeks to gain insight into this important question, focusing on the assembly and stabilization of a structure called the spindle that mediates the segregation of chromosomes during cell division.

PI_NAMEs: WIGNALL, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Admin Supp: Mechanisms of Acentrosomal Spindle Assembly and Stability during Oocyte Meiosis


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: OVERALL NARRATIVE Cardiovascular, kidney and metabolic diseases are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. This is a critical area for research development in Mississippi in view of the emerging opportunities to develop a comprehensive, multidisciplinary research center at UMMC that focuses on these major causes of mortality and morbidity. This proposal represents a plan for continued development, via Phase 3 COBRE funding, of a unique, Cardiorenal and Metabolic Diseases Research Center (CMDRC) that is dedicated to improving lives through research, discovery, innovation, and translation to prevent and reduce death and disability from cardiorenal and metabolic diseases.

PI_NAMEs: HALL, JOHN E (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Area;Basic Science;Biomedical Research;Book Chapters;Books;Cardiorenal syndrome;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Centers of Research Excellence;Cessation of life;Clinical;clinical center;Clinical Research;Collaborations;Complex;Core Facility;Coronary Arteriosclerosis;Dedications;Development;Diabetes Mellitus;disability;Discipline;Disease;Education;Ensure;Equipment;Extramural Activities;Faculty;Fostering;Funding;Grant;Healthcare Systems;High Prevalence;Hypertension;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Kidney Diseases;kidney dysfunction;Laboratory Research;Link;Mentors;Metabolic Diseases;minority investigator;Mississippi;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel therapeutic intervention;Obesity;Paper;Phase;Pilot Projects;Population;Population Research;Postdoctoral Fellow;prevent;Productivity;programs;Publishing;recruit;Renal function;Research;research and development;Research Infrastructure;Research Personnel;Resources;Scientist;Services;Stroke;student training;success;Training;Training Programs;Translational Research;Translations;Underrepresented Minority;United States;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: No changes being proposed.

PI_NAMEs: PATEL, MAULIK R (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: mitochondrial genome;mutant

PROJECT_TITLE: Mechanisms of mutant mitochondrial genome modulation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Gene Therapy;Genetics;Mucopolysaccharidoses (MPS);Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative: It has been a major unmet medical need for the development of efficient brain delivery across the blood-brain barrier with wide distribution of the therapeutic macromolecules to many types of brain cells in treating a wide variety of neurological diseases. The goal of this project is to develop a novel platform with advanced brain delivery of therapeutic proteins by coalescing in vivo epigenetic alteration of microRNA with targeted gene transfer and restricted transgene expression for improved CNS treatment of Hurler syndrome, a neurologic lysosomal storage disease (nLSD). Such therapeutic approach would have significant and broad application across many other nLSDs or neurological diseases.

PI_NAMEs: PAN, DAO  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: adeno-associated viral vector;Adult;Allogenic;Blood - brain barrier anatomy;Brain;brain cell;brain endothelial cell;caspase 14;Cell Therapy;cerebral microvasculature;Childhood;Data;Development;Disease;DNA cassette;Drug Delivery Systems;enzyme replacement therapy;enzyme therapy;Enzymes;Epigenetic Process;Erythroid;Frequencies;Functional disorder;Future;Gene Modified;Gene Transfer;Genes;Goals;Hematopoietic Stem Cell Transplantation;Hereditary Disease;Human;IGF Type 2 Receptor;IGF2 gene;IGF2R gene;improved;in vivo;Inherited;inhibitor;Knock-out;L-Iduronidase;Live Birth;Luciferases;Lysosomal Storage Diseases;Lysosomes;macromolecule;Mediating;Medical;Megakaryocytes;Metabolic;MicroRNAs;Modification;mouse model;Mucopolysaccharidosis I;Mucopolysaccharidosis I H;Mus;Mutagenesis;Nerve;Nervous System Disorder;Neurologic;novel;novel strategies;Pathway interactions;Patients;Penetration;Play;Porifera;postnatal period;preclinical evaluation;receptor;Reporter;Role;Severities;Site;System;Therapeutic;therapeutic enzyme;therapeutic protein;trafficking;transgene expression;Vascular Endothelial Cell;Viral Vector

PROJECT_TITLE: Advancing CNS drug delivery via epigenetic modulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

PHR: Project Narrative This project will construct a consensus atlas of cell types in the mammalian entorhinal cortex, a region critical for memory and navigation and vulnerable to pathology. It leverages advanced single nucleus multiomic sequencing and spatial transcriptomics to elucidate the composition and molecular evolution of cell types across 14 species, including humans and diverse model organisms. Jessie Puckett will receive comprehensive computational and biological training in this multi-disciplinary effort, enhancing the project with detailed analyses of evolutionary changes and contributing to a broader understanding of brain function and disease susceptibility.

PI_NAMEs: LEIN, ED  (contact);ZENG, HONGKUI

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Adaptive Behaviors;Alzheimer's Disease;Architecture;ATAC-seq;Atlases;Bioinformatics;Biological;Biology;Brain;career;Cell Nucleus;cell type;Chromatin;Cognition Disorders;cognitive function;Communication;Computer Analysis;Consensus;Data Analyses;Dedications;design;Development;Disease susceptibility;Education;Educational workshop;Ensure;entorhinal cortex;Episodic memory;Evolution;experience;Fostering;Gene Expression Profile;Genetic;Genomics;Growth;Hippocampus;Human;innovation;insight;Mammals;meetings;Memory;memory retrieval;Mentorship;model organism;Molecular;Molecular Evolution;multidisciplinary;multiple omics;Neocortex;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurons;Neurosciences;novel;Pathology;Pathway interactions;Play;Positioning Attribute;Process;Research;Role;Science;Scientist;single cell genomics;single nucleus RNA-sequencing;skills;Structure;symposium;Technology;Training;Training Programs;transcriptomics;trend;way finding

PROJECT_TITLE: Evolutionary Pathways of Memory: Multiomic Analysis of the Entorhinal Cortex across Mammals.


NIH_SPENDING_CATS: Nutrition

ORG_CITY: PITTSBURGH

ORG_NAME: DUQUESNE UNIVERSITY

PHR: Project Narrative Membrane homeostasis is a fundamental aspect of cell function and requires the coordinated control of multiple metabolic activities, including phospholipases involved in lipid turnover and acyltransferases involved in lipid synthesis and remodeling. Defects in membrane lipid homeostasis can contribute to the development of many diseases, including obesity, diabetes, and cancer. The proposed studies characterize a novel acyltransferase and its affect on membrane homeostasis and cell physiology. The requested Sapphire FL Biomolecular Imager provides enhanced capabilities for the performance of research essential to the grant.

PI_NAMEs: VOGT, JANA L (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acyl Coenzyme A;acyl group;Acylation;Acyltransferase;Affect;Amino Acids;Candida albicans;Catalysis;Cell Physiology;Cells;Cellular Membrane;Conversion disorder;Cytidine Diphosphate Choline;deacylation;Defect;Development;Diabetes Mellitus;Disease;Enzymes;Eukaryotic Cell;Exhibits;fluidity;Genetic Transcription;Grant;Growth;Homeostasis;Homologous Gene;imager;Laboratories;Lecithin;Lipids;Malignant Neoplasms;Medical;Membrane;Membrane Lipids;Metabolic;Metabolism;Methylation;Mutagenesis;mutant;novel;Obesity;Organism;pathogenic fungus;Pathway interactions;Performance;Phase;Phenotype;Phospholipase;Phospholipids;Property;Protein Family;Proteins;Publishing;Regulation;Research;response;Role;Route;Saccharomyces cerevisiae;Sapphire;Second Messenger Systems;Signal Pathway;Stress;Temperature;Transacylase;Vertebrates;Virulence

PROJECT_TITLE: Novel Aspects of Phosphatidylcholine Metabolism


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Public Health Relevance. In this proposal I will characterize mechanisms of regulation and induced stabilization of the oncogenic Myc family transcription factors, specifically the stabilizing influence of Aurora Kinase A (AurA). These AurA-Myc in- teractions and other regulatory protein interactions will be structurally characterized and probed in cancerous cellular environments to determine their physiological relevance. These studies will serve as a basis for under- standing the mechanisms governing Myc dysregulation, responsible for 30% of all cancers.

PI_NAMEs: DUNLEAVY, KATIE M. (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Affinity;anti-cancer;aurora kinase A;Behavior;Binding;Binding Sites;Biological;Biological Assay;Biophysics;c-myc Genes;cancer therapy;cancer type;Cancerous;cell growth;Cell Proliferation;Cells;Complex;Cryoelectron Microscopy;design;Disease;Distal;Docking;Drug Targeting;Electron Spin Resonance Spectroscopy;Environment;experience;experimental study;Faculty;Family;Family member;Fluorescence;Fluorescence Anisotropy;Fluorescence Resonance Energy Transfer;Foundations;Future;Gel Chromatography;genetic regulatory protein;Genetic Transcription;Immunoprecipitation;In Vitro;inhibitor;Institution;Kinetics;Label;Length;Life Cycle Stages;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Methodology;Mutation;MYC Family Genes;MYC Family Protein;N Domain;Nature;Neuroblastoma;novel;novel therapeutic intervention;Oncogenic;overexpression;Pattern;Phosphorylation;Phosphotransferases;Physiological;Play;Post-Translational Protein Processing;prevent;Process;programs;Protein Binding Domain;protein protein interaction;Protein-Serine-Threonine Kinases;Proteins;public health relevance;Regulation;Research;Role;Site;SKP Cullin F-Box Protein Ligases;small cell lung carcinoma;Spin Labels;structural biology;Structure;Surface;Techniques;tenure track;Therapeutic Intervention;therapeutic target;Time;time use;Tissues;Training;Transactivation;transcription factor;Transcriptional Regulation;tumorigenesis;Ubiquitin;ubiquitin ligase;Ubiquitin-mediated Proteolysis Pathway;Ubiquitination;Work;X-Ray Crystallography

PROJECT_TITLE: Defining Mechanisms Governing Myc Stability and its Modulation by Aurora Kinase A


ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT NARRATIVE  Beyond their traditionally known roles as carriers and regulators of genetic information, nucleic acids have auspiciously emerged as versatile therapies for taking advantage of cellular pathways to drive the sensing, targeting, and silencing of a variety of diseases. With MIRA support, we will explore additional nanotechnology- based therapeutic options that enlist a biocompatible nucleic acid-encoded platform (SMART NANPs) for the controlled immunostimulation and modulation of therapeutic responses. This research program aims to advance the envisioned technology towards personalized medicine and aid in addressing top public health challenges in the U.S. as they relate to cancer (through vaccines and immunotherapies), cardiovascular diseases (through regulated coagulation), and drug overdose and safety (through the biodegradable nature of the platform and its functional regulation).

PI_NAMEs: AFONIN, KIRILL A (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Architecture;Biodistribution;Biological;biomaterial compatibility;Biopolymers;cancer cell;Cardiovascular Diseases;cell behavior;Cell Physiology;Cell Reprogramming;Cells;Clinical;clinical application;Coagulation Process;Code;Communicable Diseases;data platform;Dendritic Cells;Diagnosis;disability;Disease;Drug Delivery Systems;Formulation;Funding;genetic information;Goals;Health Personnel;Human;Immune;Immune response;Immunologic Stimulation;Immunologics;Immunology;Immunotherapy;interdisciplinary approach;Interferons;Knowledge;Learning;Life;Machine Learning;Malignant Neoplasms;Modality;Molecular;monocyte;nanoparticle;Nanotechnology;Nature;next generation;Nucleic Acids;Overdose;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;prevent;Principal Investigator;programs;Property;Public Health;Regulation;Reproducibility;Research;Role;Safety;self assembly;Signal Transduction;Source;Specific qualifier value;Structure-Activity Relationship;Technology;Therapeutic;therapeutic nanoparticles;therapy outcome;Thrombin;Toxic effect;translational oncology;Translations;treatment response;Vaccines;Work

PROJECT_TITLE: MIRA supplement


ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: We seek to determine how myosin V motors choose the correct organelle cargoes, and deposit them at their new destinations. Mutations in myosin V underlie diseases in the brain, skin pigmentation and the digestive tract. Thus, insights into myosin V regulation, may provide insights into how to treat some of these diseases.

PI_NAMEs: WEISMAN, LOIS S (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Regulation of myosin V interaction with cargo-Equipment Supplement


NIH_SPENDING_CATS: Genetics;Human Genome;Microbiome

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative As residents of the human body and the biosphere, microbial communities perform essential metabolic processes for maintaining human health. At present we do not understand how the genomic structure of microbial communities, and the environment in which they reside, gives rise to their emergent metabolic processes. With to goal of ultimately designing and controlling communities of microbes to improve human health, this project aims to discover the principles governing how environmental variation impacts the metabolism of microbial collectives.

PI_NAMEs: KUEHN, SEPPE  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Environmental modulation of metabolic function in microbial communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The high tissue penetrability of ultrasound (US) waves presents untapped and exciting opportunities for accessing structures throughout the mammalian brain. In this supplement to our RF1 project, we will further advance methods pioneered in our labs to extend the depth penetration and resolution of optoacoustic imaging to support whole-brain functional imaging of distributed neuronal activity in scattering tissue, with a focus on the olfactory bulb in awake, behaving animals. These developments would break new ground in the field of brain function in large mammalian brains.

PI_NAMEs: CAMPBELL, ROBERT E.;RAZANSKY, DANIEL ;SHOHAM, SHY  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TITLE: High-resolution bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals - Diversity Supplement


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Suicide is a complex, devastating public health concern with interrelated issues of a lack of adequate available treatments, and limited understanding of the underlying pathophysiology. FDA-approved for the treatment of treatment-resistant depression (TRD), repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation intervention that has both immense therapeutic potential and a conceivable role in elucidating the pathophysiology of disease in multiple other psychiatric conditions, including suicide. The purpose of this project is to demonstrate the anti-suicidal efficacy of a new rTMS treatment paradigm (bilateral accelerated theta burst stimulation; [bilateral aTBS]) and enhance our understanding of the neurophysiological signature and treatment targets for individuals with TRD and suicidal ideation using combined TMS and electroencephalography (TMS-EEG), with the ultimate public health and patient care goals of reducing the morbidity and mortality of suicide.

PI_NAMEs: WEISSMAN, CORY R (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Adult;Aftercare;anti-depressive agents;Bilateral;Biological;Brain region;career development;Cerebral Dominance;Clinical;clinical effect;clinical efficacy;Clinical Trials;combat;completed suicide;Complex;Department chair;Diagnosis;Disease;Double-Blind Method;efficacious treatment;electric field;Electroencephalography;experience;FDA approved;Feeling suicidal;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Goals;Grant;Health;Healthcare;improved;indexing;Individual;innovation;Inpatients;Intervention;Investigation;Knowledge;Left;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mediating;Mental disorders;Mentors;Modeling;Morbidity - disease rate;neural circuit;Neurobiology;neuroimaging;Neuronavigation;neurophysiology;neuroregulation;neurotransmission;noninvasive brain stimulation;novel;novel strategies;Outcome;Paper;Participant;Patient Care;Patient Recruitments;Patients;Physician Executives;Physicians;Placebos;potential biomarker;Prefrontal Cortex;preventive intervention;programs;Protocols documentation;Psychiatry;Public Health;Publishing;Randomized;recruit;reducing suicide;repetitive transcranial magnetic stimulation;Research;Resistance;response biomarker;Risk Factors;Role;Sampling;Scientist;Signal Transduction;skills;standard care;suicidal;Suicide;suicide mortality;Suicide prevention;suicide rate;System;Techniques;Technology;temporal measurement;Testing;Therapeutic;tool;Transcranial magnetic stimulation;treatment arm;treatment duration;treatment group;Treatment Protocols;treatment response;treatment-resistant depression;trend;Work

PROJECT_TITLE: Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (06)]


NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative/Abstract Heterocycles and strained rings are valuable motifs in pharmaceuticals and natural products, thus highlighting the need for unique ways to access them. The K99 phase will establish the first total syntheses of azetidine- containing metabolites that affect biofilm and pigment production in the pathogenic bacterium P. aeruginosa; the R00 phase will center on development of distinctive methods to access multifunctional chemical building blocks. This project is relevant to the NIH’s mission because 1) in the short-term, it will expand fundamental knowledge in the synthesis of bioactive natural products and pharmaceutically relevant motifs, and 2) in the long-term, findings from biological studies of molecules in the K99 phase could lead to new anti-virulence treatments for those infected with P. aeruginosa, and methods in the R00 phase could aid in rapid access to pharmaceuticals.

PI_NAMEs: DORN, STANNA  (contact)

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Affect;Alkylation;azetidine;Behavior;bioactive natural products;Biological;Biological Process;Biomimetics;Carbamates;career;Chemicals;Complex;Creativeness;Cyclization;cystic fibrosis patients;Development;divinyl sulfone;experience;Future;Health;Human;Industry;interest;Ions;Knowledge;Mediating;member;Metals;Methods;Microbial Biofilms;Mission;Modernization;Molecular;Natural Products;novel;novel strategies;Organic Chemistry;Organometallic Chemistry;oxidation;Oxidation-Reduction;pathogenic bacteria;Periodicity;pharmacologic;Pharmacologic Substance;Phase;Pigments;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pyridones;Pyrrolidines;quorum sensing;Reaction;Research;research and development;Route;scaffold;success;System;Testing;Training;Translating;United States National Institutes of Health;Variant;Virulence;Work

PROJECT_TITLE: Access to Strained Rings and Heterocycles: Applications in the Synthesis of Bacterial Metabolites and Chemical Building Blocks


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Narrative Protection of DNA against damages and errors are integral to maintaining genomic stability. Defects in DNA metabolic processes that replicate and repair the genome lead to genetic instability and chromosomal rearrangements causing cancers, aging, and inherited disorders. Replication Protein A is central to coordinating almost all DNA replication and repair processes in the cell and our work focuses on deciphering the underlying molecular mechanisms which can be exploited to develop novel chemotherapeutics.

PI_NAMEs: ANTONY, EDWIN  (contact)

PROJECT_TERMS: Address;Adopted;Affinity;Aging;Amino Acids;Architecture;Binding;Biochemical;Biophysics;Cancer Etiology;Cells;Chromosomal Rearrangement;Complex;Defect;dexterity;Dissociation;DNA;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA damage checkpoint;DNA Maintenance;DNA metabolism;DNA Repair;DNA Repair Pathway;ds-DNA;Enzymes;flexibility;Fluorescence;Gatekeeping;Genetic;Genetic Recombination;Genome;genome integrity;Genome Stability;Goals;Hereditary Disease;Individual;Investigation;Kinetics;Knowledge;Label;Lead;Length;Metabolic;Metabolism;Modeling;Molecular;novel;Nucleosomes;Pathway interactions;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Process;Property;protein function;Proteins;recruit;repaired;replication factor A;Replication-Associated Process;Role;Single-Stranded DNA;Site;Specificity;telomere;Telomere Maintenance;Therapeutic;Thermodynamics;tool;Work

PROJECT_TITLE: Coordination of DNA Metabolism by Replication Protein A


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: The product of this research will immediately provide new, critical, and fundamental knowledge on the relative importance of mitochondrial fission adapter proteins for synaptic function. Furhter, this project will elucidate the reasons why dysfunction in the mitochondrial fission protein DRP1 is more severe than loss of mitochondrial fission adapters: we posit that DRP1 facilitates synaptic vesicle biogenesis, independent of its function in mitochondrial fission. Pursuit of this knowledge is important, as DRP1 has been identified as a therapeutic target to alleviate core causes of aging and neurodegenerative diseases such as Alzheimer’s Disease. The motivations for this project are to increase our basic science knowledge of synaptic function in the brain, and also enhance healthspan in populations increasingly subject to age-related neurological diseases.

PI_NAMEs: RENDEN, ROBERT B (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adaptor Signaling Protein;Affect;age related;Aging;Alzheimer's Disease;Basic Science;Biogenesis;Biological Models;Brain;Cell membrane;Cell Survival;Cellular Stress;Collaborations;Defect;Disease;Disease Progression;Dissection;Dynamin;Electron Microscopy;Electrophysiology (science);Endocytosis;Environment;Excitatory Synapse;Functional disorder;functional restoration;Gene Transfer Techniques;Glutamates;Goals;healthspan;Homeostasis;Huntington Disease;Intervention;Knowledge;light microscopy;Mediating;Membrane;Mitochondria;mitochondrial dysfunction;Motivation;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurotransmission;novel strategies;Outer Mitochondrial Membrane;Phenotype;Population;presynaptic;presynaptic neurons;Presynaptic Terminals;Protein Isoforms;Proteins;Recycling;Research;Research Personnel;Resolution;Respiration;response;Retrieval;Role;Route;stressor;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Testing;Therapeutic;therapeutic target;Time;Viral

PROJECT_TITLE: Dynamin-related protein 1 and mitochondrial fission adapters regulate presynaptic function

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative Large datasets in biological studies are often stored in Cloud repositories and analyzed by fast cloud computing built on Python programs. Many biology students and biomedical researchers may be unprepared for the coding demands of using these tools. We propose to build a module to train scientists to code in Python so that they can use advanced tools to interpret complex biological data sets.

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Administrative Supplement;Award;Bioinformatics;bioinformatics pipeline;Biological;Biology;Biomedical Research;cloud based;Cloud Computing;cloud platform;Code;Complex;cost effectiveness;Data;data access;Data Analyses;data pipeline;Data Science;Data Set;data sharing;Data Sources;Data Storage and Retrieval;Educational Curriculum;Educational process of instructing;Educational workshop;Exercise;Face;Faculty;FAIR principles;Foundations;Funding;Goals;graduate student;Idaho;improved;Individual;innovation;large datasets;large scale data;Learning;Learning Module;Measures;National Institute of General Medical Sciences;novel;Parents;Process;Programming Languages;programs;Protocols documentation;Pythons;repository;Research;Research Personnel;Resources;Running;Scientist;skills;Speed;Students;Testing;tool;Training;undergraduate student;United States National Institutes of Health;Update;Vocabulary

PROJECT_TITLE: Idaho INBRE Program- Cloud-Based Learning Modules


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

PHR: Aging and Parkinson's disease (PD). Aging is the primary risk factor for PD. Despite reported success with neurotrophic or neuroprotective therapeutic drugs or cell replacement therapies in animal models of PD, none have led to a clinically effective treatment avenue, curing all aspects of the disease complex. Inflammation in the brain, in particular, activation of microglia has been increasingly associated with the ongoing pathogenesis of PD. Aging impacts immune cell phenotype, reducing the efficacy some therapeutics. We have identified exosomes derived from human adipose derived stem cells as a potent modulator of inflammation. Exosomes are an ideal vector for delivery of neuroprotective agents because of their unique ability to home to tissues, and their increased stability compared to un-encapsulated RNA. This project seeks to establish exosomes as a therapeutic alternative for PD.

PI_NAMEs: BICKFORD, PAULA C (contact)

PROJECT_TERMS: adipose derived stem cell;Age;aged;Aging;aging related disease;alpha synuclein;Animal Model;animal old age;Anti-Inflammatory Agents;Area;Binding;Biological Process;Brain;Brain Injuries;cell age;Cell Line;cell motility;cell replacement therapy;Cell Survival;cell transformation;Cells;Clinical;Complex;CX3CL1 gene;Data;delivery vehicle;design;Disease;disease model;Disease Progression;DNA Sequence Alteration;Dopaminergic Cell;effective therapy;Environment;Epilepsy;exosome;Exposure to;Gene Expression;Genomics;Home;Human;Immune;immune function;Immunoprecipitation;immunoregulation;Inflammation;innate immune function;Innate Immune System;juvenile animal;MALAT1 gene;Mass Spectrum Analysis;Mediating;Membrane;microchip;Microglia;Mitochondria;Modeling;Molecular;Natural regeneration;Neurodegenerative Disorders;Neuroglia;Neurons;neuroprotection;Neuroprotective Agents;Onset of illness;Oxidative Stress;Oxidopamine;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Phagocytosis;Pharmaceutical Preparations;Phenotype;promote resilience;Proteins;Proteomics;Publishing;Rattus;Reporting;response;Risk Factors;RNA;Role;stem cell exosomes;success;Therapeutic;Tissues;tool;Toxic effect;transcriptomic profiling;transcriptomics;Untranslated RNA;Vesicle

PROJECT_TITLE: Role of Inflammation and Oxidative Stress in Parkinson's Disease