NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Opioids;Pain Research;Patient Safety

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for first-line therapy of many conditions, but allergy over-reporting and lack of reaction clarification may lead to unnecessary avoidance of NSAIDs and increased use of second line, more costly, and/or less effective treatments. Our study aims to determine how NSAID allergy labeling influences alternative medication prescribing and patient clinical outcomes, and to identify predictors for true NSAID-induced allergic hypersensitivity. This work will inform the development of new evidence-based approaches to risk stratify and target previously overlooked populations for allergy intervention, allowing delabeling and providing safer management and improving the care of drug-allergic patients.

PI_NAMEs: LI, LILY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: acute coronary syndrome;Acute Pain;Adverse effects;Adverse reactions;Affect;Allergic;Anaphylaxis;Angioneurotic Edema;Anxiety;Aspirin;Award;Biological;Biostatistical Methods;Boston;Cardiovascular system;career;Caring;chronic back pain;chronic pain;Clinical;Clinical Data;clinical epidemiology;Clinical Informatics;Clinical Investigator;Clinical Research;cohort;comorbidity;Coronary heart disease;cost;Data;Data Set;Databases;Development;Disease;Dose;Drug Hypersensitivity;Drug Prescriptions;effective therapy;Electronic Health Record;Environment;Epidemiology;epidemiology study;Evaluation;Event;evidence base;experience;Female;gastrointestinal;Goals;Health;Heart Diseases;Hemorrhage;high risk;high risk population;Hospitals;Hypersensitivity;improved;Informatics;insight;Integrated Health Care Systems;Intervention;Label;large datasets;longitudinal analysis;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Natural History;nephrotoxicity;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opioid;opioid use;opioid use disorder;Outcome;Pain;Patient Care;patient oriented;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;Postoperative Pain;Postoperative Period;prescription opioid;Protocols documentation;Reaction;Recommendation;Regimen;Regression Analysis;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;Resources;Rest;rheumatologist;Risk;Risk Factors;risk stratification;sex;side effect;skills;Specialist;Survival Analysis;Therapeutic Uses;Time;Training;United States;United States National Institutes of Health;Urticaria;Vocational Guidance;Woman;Work

PROJECT_TITLE: Clinical Impact and Epidemiology of Nonsteroidal Anti-inflammatory Drug Allergies

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Firearms Research;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it focuses on the testing of a theoretically grounded intervention to train clinicians in firearm safety counseling behaviors to prevent firearm-related injury, the leading cause of death in children aged 1-19 years. The research will provide foundational data regarding the use of automated virtual reality simulation as a deliberate practice training platform to support clinicians’ skills with the potential for broad dissemination. Thus, the proposed mentored research is relevant to NIH’s mission to support research to prevent firearm violence and reduce the related deaths, injuries, and trauma.

PI_NAMEs: REAL, FRANCIS  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 3-Dimensional;Address;Adolescent;Adult;aged;Area;Artificial Intelligence;automated intervention;Automation;Behavior;behavior change;Behavioral;career;Caregivers;case control;Cause of Death;Cessation of life;Child;Childhood;Clinical Trials;Communication;community engagement;community organizations;Control Groups;Counseling;Data;design;Development;Devices;Education;effectiveness/implementation trial;efficacy testing;efficacy trial;Environment;Evaluation;evidence base;Evidence based practice;experience;Family;Feedback;firearm access;Firearms;Focus Groups;formative assessment;Future;Goals;Gun injury;gun violence;Guns;handgun;Household;Human;implementation evaluation;implementation framework;implementation outcomes;implementation science;Injury;innovation;Institution;interest;Intervention;Intervention Trial;K-18 conjugate;Knowledge;Measures;Medical center;Medical Education;medical schools;Mentors;Mentorship;Methods;Michigan;Mission;Morbidity - disease rate;mortality;Outcome;patient population;Patients;Pediatric Hospitals;Pediatrics;Population;prevent;Prevention;Prevention Research;primary care clinic;process evaluation;prototype;Public Health;Quasi-experiment;Reporting;Research;Research Activity;Research Personnel;Research Support;Resources;Risk;Risk Factors;Safety;Secure;self-directed learning;simulation;Site;skills;Standardization;Structure;Techniques;technology intervention;Testing;Theory of Change;Time;Training;Training Programs;Trauma;United States;United States National Institutes of Health;Universities;usability;virtual;virtual reality;virtual reality intervention;virtual reality simulation;Visit;Work;Writing;Youth

PROJECT_TITLE: An Automated Virtual Reality Intervention to Enhance Firearm Safety Counseling in Pediatrics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (51)]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

ORG_STATE: MD

PHR: Project Narrative Tracking recovery and rehabilitation following distal radius fracture (DRF) open reduction and internal fixation (ORIF) is difficult since many outcome tools like patient-reported outcome measures (PROMs), functional tests, and accelerometers have limited patient-specific granularity. The application of machine learning (ML) algorithms to accelerometry analysis represents an appealing option that can achieve convenient and accurate tracking of patient-specific functional return following DRF ORIF. To improve patient-centered DRF care, this study will evaluate the value of PROMs in describing upper extremity functional use, use ML algorithms to analyze home accelerometry data to track recovery, and use early post-surgical accelerometry data to predict long-term outcomes.

PI_NAMEs: GILADI, AVIRAM MOSHE (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Affect;Algorithm Design;algorithm training;Algorithmic Analysis;Amputees;arm;Articular Range of Motion;bone fracture repair;Caring;Categories;Classification;Controlled Environment;Data;Decision Making;deep learning algorithm;Distal;Environment;Evaluation;Fracture;functional status;Goals;Hand;Home;Human;improved;Incidence;Individual;individual patient;innovation;insight;instrument;Limb structure;long term recovery;Machine Learning;machine learning algorithm;machine learning model;Manuals;Measures;Methods;Michigan;Modeling;Motor;Motor Skills;Movement;novel;Office Visits;older women;Open Fractures;Outcome;Outcome Measure;Participant;Patient observation;patient oriented;Patient Outcomes Assessments;Patients;Performance;Phase;Postoperative Care;Postoperative Period;postoperative recovery;Process;Provider;Published Comment;Questionnaires;Radius Fractures;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Reporting;Risk;sample fixation;Series;Standardization;stroke patient;Surgical Management;Task Performances;Testing;tool;Training;treatment comparison;Upper Extremity;Upper Extremity Fracture;Video Recording;wearable device;Work;Wrist

PROJECT_TITLE: Algorithmic Analyses of Accelerometry Data to Capture Meaningful Upper Extremity Use and Recovery Following Distal Radius Fracture Repair

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: This study begins to address a critical need for interventions that reduce both problem substance use (PSU) and HIV risk behavior among MSM. Given that many MSM seek HIV testing in LGBT community agencies, interventions delivered at these agencies in the context of HIV testing have the potential to reach large numbers of MSM, help them reflect on their use of drugs and alcohol, and help link those with PSU to substance abuse treatment. If proven efficacious in a future RCT, implementation of these intervention in such agencies will help address a key contributor to HIV risk behavior and infection as well as reduce drug and alcohol use among MSM, who are disproportionately affected by HIV and substance use.

PI_NAMEs: BALAN, IVAN C (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;Address;Administrative Supplement;Affect;Agreement;AIDS prevention;Alcohol consumption;Alcohols;animation;Argentina;Balan;Behavior;brief intervention;Caring;Client;Communities;Community Health;community partners;County;Data;design;Drug usage;Early Intervention;Effectiveness;efficacy trial;Electronics;Ethnic Origin;Europe;experience;Florida;Frequencies;Funding;Future;General Population;Goals;Health;Heavy Drinking;high risk;HIV;HIV risk;Human immunodeficiency virus test;illicit drug use;implementation barriers;implementation intervention;Individual;individualized feedback;Infection;Intervention;intervention program;Intervention Trial;Interview;Language;Latin America;Lesbian Gay Bisexual Transgender;Link;men who have sex with men;Mental Health;Motivation;Names;Participant;Persons;Pilot Projects;Population;Postpartum Women;preventive intervention;Process;programs;Psittacidae;Race;reduced substance use;Research;Resources;response;Risk Behaviors;Sampling;screening and brief intervention;screening guidelines;screening, brief intervention, referral, and treatment;Services;sexual risk behavior;Site;Substance abuse problem;substance abuse treatment;substance use;Substance Use Disorder;Taboo;Testing;Time;Training;United States Substance Abuse and Mental Health Services Administration;uptake;Visit;Work

PROJECT_TITLE: Adaptation of the Reflexiones Electronic Screening and Brief Intervention for U.S. MSM Seeking HIV Testing.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The proposal aims to study a non-canonical role in the viral etiology of T1D, specifically the mechanisms associated with viral entry, Ca2+-flux, induction of ER stress and how they contribute to the generation of neoantigens, that can further accelerate the loss of tolerance to b cells. These studies are of great importance and relevance to T1D as they will further define the mechanisms responsible for progression of T1D in individuals genetically predisposed to autoimmunity. Such mechanistic studies are necessary to understand how a known environmental trigger can contribute to the biological processes leading to the generation of autoantigens and better educate us in the design of therapeutic strategies to prevent these processes.

PI_NAMEs: PIGANELLI, JON D (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acceleration;Affect;amidation;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autoreactivity;B-Lymphocytes;Beta Cell;Binding;Biological Process;Calcium;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell mediated immune response;Cell Physiology;Cells;Coxsackie B Viruses;Data;deamidation;design;Diabetes Mellitus;diabetes pathogenesis;diabetic patient;Disease;endocrine pancreas development;Endoplasmic Reticulum;endoplasmic reticulum stress;Enterovirus;Enterovirus Infections;Environmental Risk Factor;Enzymes;Epitopes;Etiology;Event;Failure;Family member;Frequencies;Functional disorder;Generations;Genetic Predisposition to Disease;Gut Mucosa;Human;Immune;Immune Tolerance;immunogenic;immunogenicity;In Vitro;in vivo;Inbred NOD Mice;Individual;Infection;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Islets of Langerhans;lymph nodes;Mediating;Methodology;Modification;Mucositis;Mus;neoantigens;novel;Onset of illness;Organ Donor;Pancreas;Pathogenesis;Pathology;Patients;Peptides;peripheral tolerance;Physiological;Post-Translational Protein Processing;prevent;Process;Proteins;Publishing;Role;Self Tolerance;Specificity;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transglutaminase 2;type I diabetic;Viral;Virus Diseases;Visualization;Work

PROJECT_TITLE: Examining the Role of CVB in the Generation of Beta Cell Neoantigens and Targeted Approaches at Therapeutic Intervention


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: No PHR

PI_NAMEs: CARRASQUILLO, OLVEEN ;COLON, VIVIAN  (contact);MAYS, MARY HELEN

PROGRAM_OFFICER_NAME: ALFARANO, ALEXANDRIA SKYE

PROJECT_TERMS: Health Disparities Research;Latino;Precision Health;precision medicine

PROJECT_TITLE: NATIONAL LATINO NETWORK (NLN) FOR PRECISION MEDICINE AND HEALTH DISPARITIES RESEARCH


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Neurodegenerative;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Despite being the most common muscle disease after the age of 50, inclusion body myositis (IBM) remains of unclear etiology and refractory to any form of treatment, with almost all patients eventually becoming wheelchair dependent. Herein, we propose that the mitochondria play a primary role in IBM, and we plan on evaluating the mitochondrial function by a series of very innovative techniques. Our proposal has the potential to clarify underlying disease mechanisms, and identify new diagnostic tools and therapeutic targets.

PI_NAMEs: NADDAF, ELIE  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Age;Aging;aging related disease;Alzheimer's Disease;Antigens;ATP Synthesis Pathway;Autophagocytosis;Bioenergetics;Biogenesis;Biology;Biopsy;career development;CD8B1 gene;Cell Physiology;Cell Survival;Clinical Pathways;Clinical Trials;Coupling;cytochrome c oxidase;Data;Development Plans;diagnostic biomarker;diagnostic tool;Disease;Doctor of Philosophy;Electron Microscopy;Etiology;evidence base;Face;Failure;Fiber;Future;Genes;Goals;HLA Antigens;Immune;Immunotherapy;Impairment;Inclusion Body Myositis;Infiltration;Inflammatory;Inflammatory Infiltrate;innovation;insight;Institution;Laboratories;Link;Lipids;liquid chromatography mass spectrometry;Literature;male;Medicine;Mentors;Metabolic Pathway;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morphology;mRNA sequencing;multidisciplinary;Muscle;Myopathy;Myositis;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurologist;neuromuscular;new therapeutic target;novel;novel diagnostics;Organelles;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Play;Process;Production;protein aggregation;Protein Biosynthesis;Reactive Oxygen Species;Refractory;Research;Research Personnel;Respiration;Role;Sampling;Sarcoplasmic Reticulum;Scanning Electron Microscopy;Series;Sex Differences;Shapes;skills;stable isotope;Systems Biology;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic target;Training;transcriptomics;Translational Research;Vacuole;Wheelchairs;women subjects

PROJECT_TITLE: The Role of Mitochondria in Inclusion Body Myositis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: LEXINGTON

ORG_NAME: AMERICAN BOARD OF FAMILY MEDICINE, INC.

ORG_STATE: KY

PHR: PROJECT NARRATIVE Guidelines for treating diseases are an important way that primary care providers learn about new research. However, it takes too long for guidelines to be adopted into practice, which harms patients. We will build tools to help create more impactful guidelines and to support educational outreach on guideline updates.

PI_NAMEs: HENDRIX, NATHANIEL DAVID (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Prediction of Practice Change in Primary Care Following Guideline Updates

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

PHR: In response to severe respiratory infections like influenza and SARS-CoV-2, a mediator of inflammation called HMGB1 is released from dying cells and leads to the “cytokine storm” associated with disease progression. Our novel inducible platform produces an inhibitor of HMGB1 in response to inflammation that is expected to counteract disease and be broadly applicable against many different inflammatory agents.

PI_NAMEs: BLANCO, JORGE C (contact);VOGEL, STEFANIE N.

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adenovirus Vector;Adenoviruses;Agonist;Animal Model;antagonist;Bacterial Infections;Biological Markers;cell injury;Cells;Cessation of life;chemokine;clinically relevant;Cotton Rats;COVID-19 cytokine storm;COVID-19 pandemic;cytokine;cytokine release syndrome;Data;Dengue Virus;Development;Dimerization;Disease;Disease Progression;Ebola virus;efficacy testing;Engineering;Experimental Animal Model;Family;Gene Expression;Goals;HMGB1 gene;Homeostasis;Hospitalization;Human;human disease;human pathogen;Immune response;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;Inflammatory Response;Influenza;influenza infection;influenza virus strain;inhibitor;Injury;Innate Immune Response;innovation;insight;Intervention;Life;Ligands;Lipopolysaccharides;Lung;Mediating;Mediator;microorganism interaction;Molecular;mouse model;Multiple Organ Failure;Mus;novel;novel strategies;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Phase;pre-clinical;Predisposition;Process;Production;prototype;Publishing;Pulmonary Inflammation;receptor;Reporting;Research;Resolution;Respiratory Disease;Respiratory Tract Infections;respiratory virus;response;Rodent Model;SARS-CoV-2 exposure;SARS-CoV-2 infection;Sepsis;Severity of illness;Sigmodon;Signal Pathway;Signal Transduction;Small Business Technology Transfer Research;small molecule;Sterility;Structure;Symptoms;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;TLR4 gene;Toll-like receptors;tool;translational therapeutics;Treatment Efficacy;Viral;Virus;Work

PROJECT_TITLE: Inducible HMGB1 antagonist for viral-induced acute lung injury.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Federally qualified health centers (FQHC) need assistance with creating a work environment where their workforce thrives. We aim to shift the current clinical practice of FQHC’s leadership and management of provider and staff well-being towards a systems-based approach driven by leadership engagement and support using multi-level, multi-method assessments.

PI_NAMEs: SCHWATKA, NATALIE VIRGINIA (contact)

PROJECT_TITLE: Organizational strategies to support community health center well-being

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Rehabilitation;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Individuals with serious mental illness (SMI) experience unconscionable disparities in health and longevity, which are exacerbated by social isolation and loneliness. The objective of this career development award is to build the foundation for a unique program of research focused on how behavioral mechanisms of action (social interaction and activity engagement) can reduce social isolation among people with SMI through targeted, co-designed environmental modifications in community mental health centers. This will be achieved through an innovative, stepwise, mixed- methods research plan integrated with world-class mentorship and training in: (1) socio-spatial methods (GIS, social network analysis, and ecological momentary assessment); (2) theory interlinking environmental design, behavior and health; and (3) intervention co-design based on community-based participatory research principles.

PI_NAMEs: AGNER, JOY  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;American;Architecture;Area;Attention;Beds;Behavior;Behavioral;Behavioral Mechanisms;Bipolar Disorder;built environment;career;Clinical;Communities;community based participatory research;Community Mental Health Centers;contextual factors;cost;Data;Data Reporting;design;Development;Dose;Ecological momentary assessment;effectiveness study;Empirical Research;Environment;environmental adaptation;environmental intervention;Epidemic;experience;feasibility testing;Focus Groups;Fostering;Foundations;Frequencies;Future;General Population;Goals;Hawaii;Health;health disparity;Human;improved;Individual;innovation;interest;Intervention;Interview;K-Series Research Career Programs;Knowledge;Link;Loneliness;Longevity;Major Depressive Disorder;Measures;member;Mental Health;Mentored Clinical Scientist Development Program;Mentorship;Methodology;Methods;Modeling;Modification;mortality;multilevel analysis;National Institute of Mental Health;novel;Occupational Therapist;Outcome;Participant;Pathway Analysis;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Population;Prevalence;Process;programs;protocol development;Protocols documentation;Psychologist;Psychoses;psychosocial rehabilitation;Public Health;Recovery;Rehabilitation Centers;Reporting;Research;Research Methodology;Research Support;Schizophrenia;Scholarship;Science;Services;severe mental illness;Severities;Site;social;Social Behavior;Social Interaction;Social isolation;Social Network;Social Sciences;Social support;Structure;Surgeon;Surveys;Testing;theories;therapy development;Time;timeline;Training;United States National Institutes of Health;Variant;Visualization;Work

PROJECT_TITLE: Designing belonging: Advancing science on environmental modifications to foster activity engagement and social connection among individuals with serious mental illness

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Herpes simplex virus type 2 (HSV-2) is one of the most significant factors fueling the global HIV epidemic and coinfection is associated with higher HIV plasma viral loads and increased rates of HIV transmission. The goal of this application is to identify the mechanisms by defining the transcriptional responses to HSV-2 in HIV-infected individuals using primary cells and genital skin biopsies obtained during HSV-2 recurrences and to determine how these responses promote HIV replication. The results obtained will have broad implications and accelerate the development of strategies for HIV eradication.

PI_NAMEs: HEROLD, BETSY C. (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Acceleration;Affect;Anti-viral Therapy;antiretroviral therapy;APOCEC3G gene;ATAC-seq;Bar Codes;biobank;Biological;Biological Models;Biopsy;CD4 Positive T Lymphocytes;Cell Line;Cell model;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;co-infection;Coculture Techniques;Complex;CRISPR/Cas technology;Development;Disease Outbreaks;Disease Progression;Epidemic;epidemiology study;Epigenetic Process;epigenetic silencing;Epithelial Cells;Foundations;Frequencies;Gene Expression;Genetic Transcription;genital herpes;Genitalia;Goals;Histones;HIV;HIV Infections;HIV Long Terminal Repeat;HIV Seronegativity;HIV-1;Human Herpesvirus 2;Immune;Immunofluorescence Immunologic;In Situ;Individual;Infection;knock-down;Knock-out;Lesion;Link;lonely individuals;Maintenance;MALAT1 gene;Maps;Mediating;Messenger RNA;Modeling;Molecular;Mucous Membrane;novel strategies;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Plasma;Polycomb;prevent;Productivity;protein expression;Proteins;Proteomics;recruit;Recurrence;Repression;Resolution;response;Risk;Role;Simplexvirus;single-cell RNA sequencing;Site;Skin;skin biopsy;syndemic;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Testing;Time;Tissues;TNF gene;Transcript;transcriptome;transcriptome sequencing;transmission process;Untranslated RNA;Viral;Viral Load result;Viremia;Virus Diseases;Virus Replication

PROJECT_TITLE: Mechanisms Underlying the HIV-HSV-2 Syndemic

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE/RELEVANCE Deregulation of cullin–RING ubiquitin ligase (CRL) complexes contributes broadly to human disease, including cancer, infectious diseases, sleep disorders, metabolic diseases, degenerative neurologic disorders, etc. Notably, thalidomide and other imids, which repurpose specific cellular CRL complexes to degrade neo-substrates, have shown clinical success. The major goal of our research is to determine how CRL complexes control essential biological processes at the cellular and organismal levels, revealing yet unknown mechanisms and new therapeutic strategies for a wide range of human diseases.

PI_NAMEs: PAGANO, MICHELE  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Area;Autophagocytosis;Biochemical;Biological;Biological Process;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cell Proliferation Regulation;Cells;circadian pacemaker;Clinical;Communicable Diseases;Complex;Cullin Proteins;Dimensions;DNA Damage;DNA Repair;Enzymes;Etiology;field study;Genetic;Goals;human disease;immune modulating agents;in vivo evaluation;insight;interdisciplinary approach;interest;Laboratories;Life;Light;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Metabolic Diseases;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;New Territories;novel therapeutic intervention;Oncology;Play;Process;Proliferating;Proteomics;Regulation;Research;response;Role;Signal Transduction;Signal Transduction Pathway;Sleep Disorders;success;System;Thalidomide;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Regulation of the cell proliferation by CRL ubiquitin ligases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are overlapping but distinct conditions that are both associated with significant impairment and a lower quality of life, on average. This study will use cutting-edge neuroimaging and data science approaches to investigate key but understudied brain circuitry in these conditions: the reward system. Results will significantly inform our understanding of the neural mechanisms underlying ASD and ADHD and will ultimately contribute to the development of more personalized treatments.

PI_NAMEs: LAWRENCE, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Age;analytical method;Area;associated symptom;Attention deficit hyperactivity disorder;Autism diagnostic;autism spectrum disorder;autism symptoms;Behavior;Biology;Brain;brain circuitry;Brain region;Clinical;cognitive control;Communication;comorbidity;Complex;Data;Data Science;Data Set;data-driven model;Decision Making;Development;Diagnosis;Diagnostic;Dimensions;Disease;Dopamine;Exhibits;explainable machine learning;Functional Magnetic Resonance Imaging;Heterogeneity;Impairment;improved;Individual;Individual Differences;Investigation;Knowledge;Lead;life span;Link;Machine Learning;machine learning method;Mental disorders;Mentorship;Methods;Motivation;National Institute of Mental Health;neural;neural circuit;Neurodevelopmental Disorder;neuroimaging;neuromechanism;novel;Pathway Analysis;Pattern;personalized medicine;Pharmaceutical Preparations;Population;Positioning Attribute;precision medicine;Productivity;Property;Puberty;Quality of life;Research;Research Personnel;Rest;reward circuitry;Rewards;Role;Sample Size;Sampling;sex;social;social communication;Source;Statistical Models;Stimulus;Strategic Planning;Structure;Symptoms;System;Testing;theories;Training;Translational Research;Work

PROJECT_TITLE: Neural Substrates of Autism and ADHD: Reward Circuitry Connectivity and Individual Differences

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NeuroTech Harbor (NTH) led by Johns Hopkins and Howard Universities will gather innovators, expert mentors, and resource providers to accelerate the development of highly promising solutions to improve neurological health for all. To address the lack of women and under-represented minority innovators, it will create the nation's first incubator ecosystem with an Equitech philosophy - the belief that diversity of teams, leadership, and perspectives is a force multiplier to fuel innovation producing solutions accessible to all communities.

PI_NAMEs: ETIENNE-CUMMINGS, RALPH ;MANAYE, KEBRETEN F;NWULIA, EVARISTUS A;SARMA, SRIDEVI V. (contact);THAKOR, NITISH VYOMESH;YAZDI, YOUSEPH

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TITLE: NeuroTech Harbor: Our nation's first equitech ecosystem for neuromedical technologies


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: THAKOR, NITISH VYOMESH (contact)

PROJECT_TITLE: Resource Subawards Core


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Emergency Care;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: Portsmouth

ORG_NAME: PIROUETTE MEDICAL

ORG_STATE: NH

PHR: Project Narrative The opioid crisis has touched every state in America, with 106,000 Americans dying of opioid overdose in 2022. Naloxone is a frontline life-saving measure that has significantly decreased mortality from opioid overdose; however, too often it must be administered by untrained laypersons under situations of extreme duress – which studies show leads to misuse, accidents, wasted doses, and tragic consequences. Pirouette has designed a novel, low-cost, and intuitively easy-to-operate auto-injector called REZQGO that even an untrained bystander could use to deliver a lifesaving dose of Naloxone safely and quickly.

PI_NAMEs: CULLINANE, CONOR R (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Accidents;Address;Administrative Supplement;Ambulances;American;Attention;Award;Benchmarking;Caregivers;cold temperature;Comparative Study;conditioning;cost;Data;design;Development;Devices;Dose;Drug abuse;drug efficacy;Drug Kinetics;Emergency medical service;emergency service responder;Environment;Equipment;ergonomics;Excision;experience;Feedback;Freezing;Frequencies;Funding;Glean;Hand;Height;Hospitals;Human;improved;In Vitro;Individual;Injections;Injury;Instruction;Intramuscular;Intuition;Label;Laceration;Life;Marketing;Measures;Mechanics;Medical;Medical Staff;meetings;Methods;Movement;Naloxone;naloxone dosing;Needles;Needlestick Injuries;Nose;Notification;novel;Opiate Addiction;Opioid;Opioid Antagonist;opioid epidemic;opioid mortality;opioid overdose;overdose death;parent project;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phase;portability;Predisposition;Regimen;Research;research study;Risk;risk minimization;Safety;Shapes;statistics;Stress;System;Temperature;Testing;Time;Torque;Touch sensation;Training;Treatment Protocols;Update;usability;User Compliance;user-friendly;Ventilatory Depression;Visual;wasting;Work

PROJECT_TITLE: A Rugged, Reliable, Portable, Safe, and Simple Naloxone HCl Auto-Injector forLife-Saving Treatment of Opioid Overdose


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Cancer;Diabetes;Osteoarthritis;Wound Healing and Care

ORG_CITY: Irvine

ORG_NAME: SYNTR HEALTH TECHNOLOGIES, LLC

PHR: Project Narrative Automation is key for usability in a clinical setting to help reduce user interaction, provide repeatability and reproducibility, and maintain cleanliness. This project will automate an FDA-registered system for microsizing autologous adipose tissue for the use in regenerative medicine, as well as for dissociating tumor tissue into single cells for cancer diagnostics. This project will provide a valuable role in developing a fully automated system for the use in multiple medical procedures in the regenerative medicine field.

PI_NAMEs: ZOBI, AHMED NABIL (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: Adipose tissue;Adoption;aging population;Animal Model;Autologous;Automation;Back;brain tissue;cancer cell;Cancer Diagnostics;Cells;Clinical;Clinical Data;Dedications;Degenerative polyarthritis;Devices;diabetic;Diabetic Foot Ulcer;diabetic ulcer;Dissociation;experience;Grant;Growth;healing;Health Technology;Heterogeneity;Human;Individual;Injections;Intra-Articular Injections;Kidney Neoplasms;Knee joint;Knee Osteoarthritis;Liver;Malignant Neoplasms;Mammary Gland Parenchyma;Marketing;Medical;Microfluidics;Modality;North America;Obesity;Patients;Phase;Population;Procedures;Process;Regenerative Medicine;Reproducibility;Role;single cell analysis;Small Business Innovation Research Grant;System;Technology;technology platform;tissue processing;Tissues;Translating;Tumor Tissue;usability;wound closure

PROJECT_TITLE: Device Automation of an FDA-cleared CD-Microfluidic Platform for Rapid Tissue Microsizing


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE There is currently no therapy that can prevent the development of epilepsy after brain trauma. Here we propose to test the efficacy of a novel compound, and determine its efficacy and tolerability in an animal model of posttraumatic epilepsy, in a setting that resembles the clinical practice of care of people with severe traumatic brain injury. We also aim to identify and validate novel biomarkers that can predict who will develop epilepsy and who may respond to a treatment that can prevent epilepsy, in hope that this may accelerate and optimize future efforts to develop new antiepileptogenic therapies.

PI_NAMEs: AGOSTON, DENES V.;COLES, LISA D;DUNCAN, DOMINIQUE ;GALANOPOULOU, ARISTEA S (contact);MAZARATI, ANDREY M;O'BRIEN, TERENCE JOHN;STABA, RICHARD

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;acquired epilepsy;Acute;Advisory Committees;Advocate;Anatomy;Animal Model;Anticonvulsants;Antiepileptogenic;Autophagocytosis;Axon;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker selection;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Brain Pathology;Calcium-Binding Proteins;California;candidate marker;Caring;Cell Death;Cessation of life;Classification;Clinical;clinical practice;Collaborations;college;Corpus Callosum;Data;Deposition;design;Development;Discriminant Analysis;Disease;Double-Blind Method;early detection biomarkers;Early Post-Traumatic Seizures;Early treatment;efficacy testing;Electroencephalography;Epilepsy;Epileptogenesis;experience;External Capsule;fluid percussion injury;Free Radicals;functional outcomes;Funding;Future;Glial Fibrillary Acidic Protein;Guidelines;Health Services;Hemorrhage;High Frequency Oscillation;high standard;histological stains;HMGB1 gene;Image;improved;in vivo;Inflammatory;Injury;Interferon Type II;Interleukin-1 beta;International;Intervention;Investigation;Iron;Iron Chelation;Isoenzymes;Laboratories;Lateral;Learning;Levetiracetam;Link;Machine Learning;Magnetic Resonance Imaging;Medicine;Memory;Metabolic;Minnesota;Modeling;Modification;Molecular;Monitor;Motor;multimodality;National Institute of Neurological Disorders and Stroke;Neuroglia;neuroimaging;Neurons;novel;novel marker;Oxidative Stress;Pathologic;Pathology;Patients;Peripheral;Persons;pharmacokinetic model;Physiological;Plasma;Populations at Risk;Post-Traumatic Epilepsy;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Predictive Value;prevent;primary endpoint;Process;prophylactic;protein biomarkers;Randomized;Rattus;Recovery of Function;Research;Risk;Risk Factors;Seizures;Site;standard of care;synergism;tau Proteins;tau-1;Testing;Therapeutic;Time;Tissues;Translational Research;Traumatic Brain Injury;treatment response;ubiquitin C-terminal hydrolase;Universities;University Health Services;Visuospatial

PROJECT_TITLE: Translational Platform for Epilepsy Therapy and Biomarker Discovery


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: There is currently no effective treatment for motor neuron (MN) disorders in part due to a lack of understanding of the molecular mechanisms that allow distinct MN subtypes to acquire and maintain their function-defining properties. We recently identified several evolutionarily conserved regulatory factors (e.g., UNC-3, BNC-1, PBRM-1) that control MN subtype development and function, and the proposed research will employ cutting-edge methods to illuminate their molecular mechanism of action. Completion of these experiments will advance our understanding of how MNs become and remain functional, aiming to provide key insights into the etiology, diagnosis or treatment of MN disorders.

PI_NAMEs: KRATSIOS, PASCHALIS  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Activator Appliances;Adult;Amyotrophic Lateral Sclerosis;Auxins;Basic Science;Binding;Binding Sites;Biological Models;Brain Stem;Caenorhabditis elegans;Cell Adhesion Molecules;cell type;Cells;cholinergic;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Code;CRISPR/Cas technology;Data;Defect;Development;Developmental Delay Disorders;Diagnosis;differential expression;Disease;Ectopic Expression;effective therapy;Embryo;Endowment;Ensure;Etiology;Event;experimental study;fly;Genes;Genetic Models;Genetic Screening;Genetic Transcription;genome-wide;Goals;Human;Human Pathology;Individual;insight;Ion Channel;knock-down;Lead;Life;Light;Locomotion;Maintenance;Membrane;Methods;model organism;Molecular;Molecular Mechanisms of Action;Morphology;Motor;motor control;motor neuron development;Motor Neuron Disease;motor neuron function;Motor Neurons;Mus;Mutate;Mutation;Nematoda;Nerve;Nervous System;Neurons;Neuropeptides;Neurotransmitter Receptor;Orthologous Gene;Outcome;Predisposition;prevent;Property;Proteins;receptor;Repression;Research;Role;Secure;Spinal;Spinal Cord;Spinal Muscular Atrophy;Syndrome;System;Testing;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Molecular mechanisms of motor neuron terminal identity

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Loss of neurons that produce the neuromodulatory neurotransmitter acetylcholine in the basal forebrain are correlated with cognitive decline in Lewy Body Dementia, and loss of these neurons is predictive of patients with Parkinson’s Disease developing Parkinson’s Disease Dementia. This project aims to understand how loss of acetylcholine release or signaling in mouse models of Lewy Body Dementia lead to cortical dysfunction and subsequent cognitive decline. The successful completion of this project will not only lead to a better understanding of how cortical dysfunction leads to cognitive decline, but will also lead to a better understanding of how to leverage cholinergic signaling for novel therapeutics in Lewy Body Dementia.

PI_NAMEs: MOEHLE, MARK S (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;alpha synuclein;Alzheimer's Disease;Anatomy;Animal Model;Attention;Basal Cell;basal forebrain;Behavioral;Brain;Brain region;Cell Nucleus;Cells;cholinergic;Cognition;Cognitive;comparison control;Data;Data Correlations;Dementia;Dementia with Lewy Bodies;designer receptors exclusively activated by designer drugs;Electrophysiology (science);Executive Dysfunction;executive function;experimental study;flexibility;Functional disorder;Glutamates;hippocampal pyramidal neuron;Impaired cognition;Impairment;insight;Lead;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Link;Long-Term Depression;Measures;Medial;Modeling;mouse model;Mus;Muscarinic Acetylcholine Receptor;Nervous System Disorder;neuron loss;neuronal circuitry;neuronal excitability;Neurons;neuroregulation;Neurotransmitters;Nicotinic Receptors;novel therapeutic intervention;novel therapeutics;Output;Parkinson Disease;Parkinson's Dementia;Pathologic;Patients;pharmacologic;postsynaptic;pre-formed fibril;Prefrontal Cortex;presynaptic;Property;Pyramidal Cells;receptor;Regulation;Role;Series;Signal Transduction;Source;Symptoms;Synapses;Synaptic plasticity;synucleinopathy;System;Testing

PROJECT_TITLE: Cholinergic Mechanisms in Lewy Body Dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Focal cortical dysplasia (FCD) is a common cortical malformation associated with medically refractory epilepsy and most frequently caused by variants in subunits of the GATOR1 complex (a negative regulator of mTOR): DEPDC5, NPRL3, and NPRL2. The least studied of these variants is NPRL2 and in this proposal we aim to define the pathophysiological consequences of Nprl2 KO in vivo and in vitro. Using a mouse model of FCD we will define the morphological and functional changes that occur due to Nprl2 KO-induced mTOR pathway hyperactivation as well as investigate the transcriptomic changes that occur downstream of mTORC1 that may produce MCD and seizures.

PI_NAMEs: IFFLAND, PHILIP HENRY (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;AKT3 gene;Amino Acids;Animals;Architecture;autism spectrum disorder;Binding;Biological Assay;brain malformation;brain tissue;Cell Aggregation;cell cortex;Cell Size;cell type;Cells;Cellular Morphology;Cerebral cortex;Childhood Neurological Disorder;Complex;Cortical Dysplasia;Cortical Malformation;CRISPR/Cas technology;Defect;Dendrites;Dependence;Development;Developmental Delay Disorders;differential expression;Disease;Dissociation;EIF4EBP1 gene;Electroencephalography;Electroporation;Ephrin-A5;Epilepsy;experimental study;Fluorescence;FRAP1 gene;Future;Genes;genetic variant;Growth;Harvest;Image;Image Cytometry;Immunochemistry;immunocytochemistry;in utero;In Vitro;in vivo;Individual;Intellectual functioning disability;Intractable Epilepsy;Knowledge;Lesion;Link;Lysosomes;Manuals;Measurement;Medical;Modeling;Monitor;Morphology;mouse model;mTOR Inhibitor;mTORopathies;Mus;Neurodevelopmental Disorder;neuronal cell body;Neurons;new therapeutic target;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;PIK3CG gene;Plasmids;pre-clinical;Precision therapeutics;preclinical study;Process;Protein Subunits;Proteins;Proto-Oncogene Proteins c-akt;pup;Regulator Genes;Resected;Resistance;response;Role;Seizures;Signal Transduction;single nucleus RNA-sequencing;Sirolimus;Somatic Mutation;Specimen;Starvation;STAT3 gene;Structure;Testing;transcriptome;transcriptomics;TSC2 gene;Variant;Western Blotting

PROJECT_TITLE: The role of NPRL2 loss in focal cortical dysplasia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Developing disease-modifying therapies for neurodegenerative diseases is notoriously diﬃcult and is exacerbated by the lack of accurate statistical models to identify the optimal time for intervention. Here, we will use ﬁve longitudinal datasets of Huntington disease, a genetic neurodegenerative disease, to propose new statistical strategies to accurately estimate the disease course. These strategies can be used to help researchers identify when an experimental therapy could best modify the disease course, and help design a well-powered clinical trial to test that therapy.

PI_NAMEs: GARCIA, TANYA PAMELA (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Area;Behavioral;clinical diagnosis;Clinical Trials;Clinical Trials Design;Cognitive;cohort;Data;Data Set;design;Disease;Drops;Enrollment;Funding;Genetic;Huntington Disease;improved;Intervention;Investigational Therapies;Joints;Lead;longitudinal dataset;Measurement;Measures;Methods;model building;Modeling;Modification;Motor;Neurodegenerative Disorders;neuroimaging;open source;Patients;prevent;Research Personnel;Science;Scientist;semiparametric;Source Code;Statistical Models;Symptoms;Testing;theories;Time;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Developing a Robust and Efficient Strategy for Censored Covariates to Improve Clinical Trial Design for Neurodegenerative Diseases

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative In the central nervous system, the activation of NMDA (N-methyl-D glutamate) receptors produces electrical currents that are essential for brain functions such as cognition, learning, and memory. Excess electrical currents cause cellular loss in stroke, brain and spinal cord injuries, and age-related diseases such as Alzheimer’s and Parkinson’s. In this project we will study how the internal parts of the receptor move during activation and how prospective drugs or clinically identified mutations alter these motions, to gain the basic knowledge that will enable the design of more effective therapeutic approaches for the many neurological conditions involving NMDA receptors.

PI_NAMEs: POPESCU, GABRIELA K (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Affect;age related;age-related disease;Alzheimer's Disease;atomic interactions;Brain;Calcium;causal variant;Central Nervous System;Chronic;Clinical;Cognition;Conscious;desensitization;design;Diagnosis;Disease;Genetic;genetic variant;Grain;Kinetics;Knowledge;Learning;Measurement;Mediating;Memory;Modeling;Molecular;Molecular Conformation;molecular dynamics;Motion;Mutation;N-Methyl-D-Aspartate Receptors;N-methyl-D-glutamate;N-Methylaspartate;Neurologic;Neurons;neuropsychiatric disorder;Output;Parkinson Disease;Pathology;Patients;Pattern;Pharmaceutical Preparations;Physiology;programs;prospective;Reaction;receptor;Receptor Activation;release of sequestered calcium ion into cytoplasm;Research;small molecule;spinal cord and brain injury;Stroke;Structure;Synapses;Testing;Therapeutic;therapeutic target;therapeutically effective;Thermodynamics;transmission process;Variant

PROJECT_TITLE: Molecular Physiology of NMDA Receptors


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Opioids;Pain Research

ORG_CITY: SAN DIEGO

ORG_NAME: NAVEGA THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Due to the lack of efficacious alternative treatment options, chronic pain is often treated with opioids despite the risk of addiction and side effects. With the advent of gene therapy, it is now possible to specifically target pain pathways at the molecular level. The goal of this study is to further develop and evaluate the efficacy and safety of a non-addictive, alternative analgesic that can epigenetically repress expression of NaV1.7, a sodium channel that is important for sensing pain.

PI_NAMEs: ALEMAN GUILLEN, FERNANDO  (contact);MORENO, ANA MARIA

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: addiction;Affect;alternative treatment;Analgesics;animal efficacy;Animal Model;animal safety;Antibodies;Binding;Biological Assay;Burning Pain;cancer survival;Cell Line;Cells;cellular transduction;Chromatography;chronic pain;chronic pain management;clinical development;Clinical Trials;Congenital Pain Insensitivity;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;density;Dependovirus;design;Development;Diabetes Mellitus;Disease;DNA;dosage;Dose;drug development;Drug Kinetics;Economic Burden;efficacious treatment;efficacy evaluation;Elderly;Engineering;Epigenetic Process;epigenome;Erythromelalgia;Evaluation;Failure;Feasibility Studies;gain of function mutation;gene therapy;Genome;Goals;Guide RNA;Harvest;healing;Human;Human Cell Line;improved;In Vitro;induced pluripotent stem cell;innovation;interest;lead candidate;lead optimization;Libraries;Limb structure;loss of function;manufacture;Methods;Molecular;Molecular Conformation;Mus;Mutation;Neurons;nonhuman primate;novel;novel therapeutics;Opioid;opioid epidemic;Organ;Pain;Pain management;pain reduction;pain relief;Pathway interactions;Patients;Peptides;Persistent pain;Persons;Pharmaceutical Preparations;Phase;Plasmids;Population;pre-clinical;prescription opioid;Prevalence;promoter;Proteins;Quality of life;rational design;Reagent;Repression;response;restraint;Risk;RNA;Safety;safety study;screening;side effect;small molecule inhibitor;Societies;socioeconomics;Sodium Channel;Specificity;Spinal Ganglia;Survival Rate;System;Testing;Therapeutic;Time;Toxic effect;Toxicology;Transcription Repressor;Transfection;transgene expression;Transgenes;Translating;Tropism;Variant;Zinc Fingers

PROJECT_TITLE: Preclinical optimization of a gene therapy for erythromelalgia and chronic pain

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Nanotechnology;Neurosciences;Stroke

ORG_CITY: SAINT LOUIS

ORG_NAME: UNANDUP, LLC

ORG_STATE: MO

PHR: There are more than 700,000 annual acute ischemic stroke (AIS) events in the US which result in nearly 150,000 deaths, making AIS the fifth leading cause of death and the leading cause of neurological disability. Although thrombectomy is the standard of care for those diagnosed with a treatable large vessel occlusion in the anterior circulation, improvements in thrombolysis are needed given that most AIS events are not amenable to thrombectomy. UNandUP (short for “Unmet Needs and Underserved Populations”) has invented a safe and effective nanoparticle-based magnetic thrombolysis platform which can be applied to nearly all AIS victims.

PI_NAMEs: CREIGHTON, FRANCIS MILTON (contact);DERDEYN, COLIN PIETER

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: 3D Print;absorption;Acceleration;Acute;Alteplase;Ambulances;American;Animal Model;Animals;Anterior;Biodistribution;Biological;Biological Assay;biomaterial compatibility;Blood;Blood coagulation;Blood flow;Brain;Caring;Cause of Death;Cessation of life;Circulation;Coagulation Process;cost;Custom;Cyclic GMP;Cytolysis;Data Set;Deterioration;Development;Diagnosis;Diffusion;disability;Dose;Drug Kinetics;Economic Burden;efficacy study;Eligibility Determination;Embolism;Ensure;Family suidae;FDA approved;Fibrinogen;Fibrinolytic Agents;Goals;Half-Life;hemodynamics;Hemorrhage;Hospitals;Hour;Human;improved;In Vitro;in vivo;Infusion procedures;invention;Iron;iron oxide;Ischemic Stroke;Knowledge;Location;Magnetic nanoparticles;Magnetism;Marketing;Measures;Mechanics;meetings;Metabolism;Methods;millimeter;Modeling;Morphology;nanoparticle;Neurological disability;Neurological outcome;novel;Organ;Palliative Care;Pathway interactions;Patient Transfer;Patients;Performance;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Plasma;portability;prevent;Procedures;Process;programs;prototype;Publishing;Rattus;Reaction;Reperfusion Therapy;Resolution;response;Risk;Rodent;Safety;safety assessment;safety study;Sex Distribution;Silicon Dioxide;Speed;standard of care;Stroke;stroke event;stroke intervention;stroke outcome;stroke therapy;stroke victims;success;Surface;System;Techniques;Technology;Thrombectomy;thrombolysis;Time;tool;Underserved Population;United States

PROJECT_TITLE: Low-Dose Magneto-Thrombolysis to Expand Stroke Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

PHR: Project Narrative This proposal will explore the role of mitochondria and oxidative stress in astrogliosis associated with acquired epilepsy. The major goal is to investigate the role of mitochondrial redox processes in initiating seizure-induced astrogliosis. The studies can have a sustained impact on the field and result in novel metabolism-based therapies to control neuroinflammation in epilepsy.

PI_NAMEs: PATEL, MANISHA N (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Adult;Antioxidants;Astrocytes;astrogliosis;Award;Bioenergetics;Brain;Brain Injuries;Calcium;calmodulin-dependent protein kinase II;Cell Death;Chronic;clinical application;comorbidity;Convulsants;Cysteine;cytokine;Deacetylase;Embryo;Epilepsy;Functional disorder;Generations;Glial Fibrillary Acidic Protein;Glucose;Goals;Image;Impaired cognition;In Vitro;in vivo;Inflammation;Injury;innovation;kainate;Laboratories;Literature;Mass Spectrum Analysis;Mediator;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Modification;mouse model;mRNA Expression;Mus;mutant;neuroinflammation;neuronal excitability;Neurons;Neurotransmitters;novel;novel therapeutics;Oxidants;Oxidation-Reduction;Oxidative Stress;Pilocarpine;Post-Translational Protein Processing;Process;Prosencephalon;protein expression;Proteins;Reactive Oxygen Species;Regulation;Role;Seizures;Sirtuins;Site;SOD2 gene;Status Epilepticus;Testing;therapeutic target;tool;two-photon;Up-Regulation

PROJECT_TITLE: Mitochondrial Mechanisms of Astrogliosis in Epilesy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Hematology;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative The proposed study investigates how cerebral aneurysm treatment outcome can be predicted through computer simulations. Typical simulations do not account for clotting factors in the blood, which are important in determining which treatments succeed and which fail. We will incorporate these aspects into computer simulations and validate them with an animal model of cerebral aneurysms for cerebral aneurysm treatment outcome prediction. This project has an impact on public health by improving the prevention of hemorrhagic stroke from aneurysm rupture and improving treatment.

PI_NAMEs: LEVITT, MICHAEL ROBERT (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Aftercare;Aneurysm;Animal Model;Animals;Area;Attention;Biological;Blood;Blood Coagulation Factor;Blood flow;Blood Platelets;blood product;Blood Vessels;Brain hemorrhage;Cerebral Aneurysm;cerebral hemodynamics;Clinical;clinical predictors;cohort;Computer Models;Computer Simulation;Decision Making;Devices;direct application;Environment;experience;Failure;Feasibility Studies;Foundations;Funding;Goals;healing;hemodynamics;Histologic;Histology;holistic approach;Human;improved;In Vitro;in vivo;innovation;insight;Liquid substance;Methodology;Methods;Modeling;novel;Oryctolagus cuniculus;Outcome;outcome prediction;particle;Patients;Platelet aggregation;predict clinical outcome;Prevalence;Prevention;Prognosis;Public Health;Radiology Specialty;Recording of previous events;Recurrence;Research;residence;Retreatment;Risk;Role;Rupture;Ruptured Aneurysm;shear stress;simulation;Stents;success;Therapeutic Embolization;Thrombosis;Thrombus;Time;Tissues;Treatment Failure;Treatment outcome;treatment risk;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Computational modeling of platelets and thrombosis in cerebral aneurysm treatment

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: Project Narrative Despite much effort to identify mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration dementia (FTLD or FTD), effective treatments remain elusive. Motoneuron (MN) excitability dysfunction is tightly linked to disease pathology, yet to date, excitability dysregulation has not been examined in the recent rNLS8 mouse model, which recapitulates pathologic TDP43 inclusions seen in MNs in >90% of ALS patients and in FTD patients. This proposal is relevant to public health because it will examine excitability dysregulation in this highly relevant model of ALS/FTD.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ALS patients;Amygdaloid structure;Amyotrophic Lateral Sclerosis;Animal Model;Area;Automobile Driving;Brain;Cessation of life;cholinergic;comorbidity;Compensation;Conflict (Psychology);Corpus striatum structure;Data;Dementia;Disease;DNA-Binding Proteins;Down-Regulation;Drug Targeting;effective therapy;Electrophysiology (science);Event;Exhibits;FDA approved;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Grant;Hippocampus;Hyperactivity;Immunohistochemistry;Individual;Ion Channel;Knowledge;Kv2.1 channel;Life;Link;Measures;Modeling;Motor Neurons;mouse model;Mus;Muscle fasciculation;mutant;Mutation;neuron loss;neuronal excitability;Neurons;neuroprotection;new therapeutic target;novel;Paralysed;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;protein TDP-43;Public Health;Reporting;Research;response;Riluzole;Role;Severities;Spinal;Spinal Cord;Superoxide Dismutase;Symptoms;Synapses;synaptic function;TDP-43 aggregation;Western Blotting

PROJECT_TITLE: Excitability dysfunction mechanisms underlying the TDP43-dependent ALS and FTD pathogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

PHR: Public Health Relevance Statement Mental health disorders often involve disruptions of neuromodulatory systems. While oxytocin signaling has been implicated in autism, schizophrenia and other brain disorders, we know little about where and when oxytocin is released within the brain, or how it affects the circuits that regulate socio-spatial behaviors. Here, we take a multidisciplinary team approach to the synaptic, neuronal and circuit effects of oxytocin and the fundamental mechanisms by which this modulator affects parental care, adult social behavior, and cognitive function.

PI_NAMEs: TSIEN, RICHARD W (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Achievement;Adult;Affect;animal data;Animals;Area;autism spectrum disorder;Behavior;Behavior Control;Behavioral;Biological;Biophysics;Brain;Brain Diseases;BRAIN initiative;Brain region;career development;Caring;Central Nervous System;Child Rearing;cognitive function;Collaborations;commune;Communication;Communities;comparative;Complex;Computer Models;Core Facility;Crying;data curation;Data Science;Data Science Core;Decision Making;Development;Ecosystem;Ensure;Environment;experience;Extramural Activities;fitness;flexibility;Fostering;functional outcomes;Funding;Goals;Hippocampus;Hormones;Human;Hypothalamic structure;Image;improved;in vivo;Individual;Infant;innovation;interdisciplinary approach;Interdisciplinary Study;interest;Investments;Ion Channel;Knowledge;Lateral;Lead;Learning;life span;Literature;Mediating;medical schools;member;Memory;Mental disorders;Mentors;Methods;Molecular;multidisciplinary;Mus;neural;neural circuit;neuronal excitability;Neuronal Plasticity;Neurons;Neuropeptides;neuroregulation;next generation;offspring;Output;Oxytocin;Oxytocin Receptor;Pattern;peptide hormone;Peripheral;Physiological;Physiological Processes;Population;Postdoctoral Fellow;Property;public health relevance;Reagent;Reporting;repository;Reproduction;Research Personnel;Research Project Grants;Schizophrenia;selective attention;Signal Transduction;social;Social Behavior;social deficits;Social Dominance;Social Hierarchy;Social Interaction;social learning;Social Network;social relationships;sound;Source;Spatial Behavior;spatiotemporal;Stimulus;Structure;Students;success;supportive environment;Synapses;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;theories;Therapeutic;tool;Training;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: Oxytocin Modulation of Neural Circuit Function and Behavior


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Myelin is essential for rapid nerve signaling and its loss in diseases like multiple sclerosis or after injury causes severe disability in patients. We propose to harness innovative tools and methods we developed to increase our fundamental understanding of how myelin forms normally during vertebrate central nervous system development, using both in vivo and primary cell culture approaches. These studies will contribute knowledge toward our ultimate goal of promoting remyelination in patients to reduce the burden of neurological diseases.

PI_NAMEs: ZUCHERO, JOHN B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Automobile Driving;Axon;cell fixing;cell motility;Cells;Cellular biology;Central Nervous System;Chronic;comparison control;Compensation;conditional knockout;Cytoskeleton;Data;Demyelinating Diseases;Development;disability;Disease;Dissection;Dorsal;Electron Microscopy;Foundations;Future;Genes;Genetic;Goals;Growth Cones;Image;Impairment;in vivo;Injections;Injury;innovation;jasplakinolide;Knowledge;Light;light microscopy;live cell imaging;Measures;Mediating;Membrane;Methods;Microfilaments;Microscopy;Modeling;Morphology;multidisciplinary;Multiple Sclerosis;Multiple Sclerosis Lesions;Mus;Myelin;Myelin Sheath;myelination;Neonatal;neonatal mice;nervous system development;Nervous System Disorder;neuronal growth;Neurons;neurotransmission;novel;Oligodendroglia;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phenotype;Positioning Attribute;prevent;Primary Cell Cultures;Process;promoter;Proteins;PTEN gene;remyelination;Reporter;Research;Resolution;Role;Specificity;Spinal Cord;Stains;superresolution microscopy;Techniques;Testing;Time;Tissues;tool;translational study;Vertebrates;Viral

PROJECT_TITLE: How Does Actin Disassembly Drive Myelin Wrapping?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The most common cause of idiopathic and familial Parkinson’s disease, an adult onset movement neurodegenerative disorder, are mutations in leucine-rich repeat kinase 2 (LRRK2). The overarching goal of this proposal is to understand the underlying mechanisms of mitochondrial DNA damage, a shared phenotype between LRRK2-associated and idiopathic PD. It is hoped that cellular pathways involved in maintaining mitochondrial genome integrity will reveal potential new therapeutic strategies to treat this devastating disease.

PI_NAMEs: SANDERS, LAURIE H (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Adult;age related neurodegeneration;alpha synuclein;ataxia telangiectasia mutated protein;ATM activation;ATM function;Automobile Driving;Autopsy;Biochemical;Bioenergetics;Biological;brain tissue;Cell Death;Data;Defect;Dependence;Development;Disease;disease model;Disease Progression;DNA Damage;DNA lesion;DNA Repair;DNA Sequence Alteration;dopaminergic neuron;Dose;Etiology;Exposure to;Fibroblasts;Foundations;Functional disorder;Genetic;genome integrity;Goals;Health;Homeostasis;Human;human induced pluripotent stem cells;Idiopathic Parkinson Disease;Impairment;in vivo;induced pluripotent stem cell;insight;Investigation;kinase inhibitor;Knowledge;Link;LRRK2 gene;Mediating;member;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Modeling;Molecular;Movement;Movement Disorders;Mus;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;neurotoxic;novel;novel therapeutic intervention;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Preclinical Testing;Proteins;Publishing;Reactive Oxygen Species;repaired;Reporting;response;Role;Signal Transduction;Techniques;Testing;Therapeutic;therapeutic target;toxicant;trafficking;Translating

PROJECT_TITLE: Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The human brain has approximately equal numbers of glia cells and neurons, and interactions between these cells are essential for all nervous system functions. Impaired glia-neuron interactions underlie many neurological diseases including Alzheimer’s disease, Autism, epilepsy and may contribute to age-related neural decline. To understand glial contribution to nervous system health, aging and disease, we will dissect glia-neuron interactions with exquisite speed and molecular resolution in vivo by using a powerful genetic model we recently established.

PI_NAMEs: SINGHVI, AAKANKSHA  (contact)

PROJECT_TERMS: Address;Age;age related;age related decline;Aging;Alzheimer's Disease;Animal Behavior;Animals;autism spectrum disorder;Binding;Biological Assay;Brain;Caenorhabditis elegans;Cell Shape;cell type;Cells;Cellular biology;cellular imaging;Code;combinatorial;connectome;Cues;Dendritic Spines;Disease;disease model;Dissection;Environment;Epilepsy;Functional Imaging;Future;Genes;Genetic;Genetic Models;Genomics;Goals;Health;Health system;Hermaphroditism;Human;Impairment;in vivo;Individual;information processing;Instruction;Interneurons;Kinetics;Learning;life span;Logic;Maps;Memory;Modeling;Molecular;Monitor;mutant;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neuroglia;Neurons;Neurophysiology - biologic function;novel;Parkinson Disease;Pathway interactions;Perception;Property;Protein Biochemistry;proteostasis;Reproducibility;Research;Resolution;Role;Sensory;sex;Shapes;Site;Specific qualifier value;Specificity;Speed;Study models;System;Techniques;Testing;tool

PROJECT_TITLE: Molecular dissection of glia-neuron interactions


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The diversity, population size, and health challenges of metropolitan Houston provides an ideal setting for a NIMHD Research Centers in Minority Institutions (RCMI). The University of Houston (UH) proposes to establish the Helping Everyone Achieve a LifeTime of Health (HEALTH) Center for Addictions Research and Cancer Prevention to advance institutional infrastructure to pursue cutting-edge health-equity science. Investing in health-equity science has the potential to save lives and improve the overall quality and length of life for some of our most vulnerable populations.

PI_NAMEs: BEECH, BETTINA M. (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Acceleration;addiction;Address;Administrator;Area;Asian;Asian Americans;Biometry;Black race;cancer prevention;career;Chronic Disease;Collaborations;college;Communicable Diseases;Communities;community advisory board;community engaged research;community engagement;community research;Competence;cost effective;Data;data management;Degree program;design;Development;Diagnosis;Disparity;Early Diagnosis;Educational Materials;Educational workshop;Equity;Ethics;ethnic diversity;Formulation;Funding;Grant;Health;Health Disparities Research;health disparity;health equity;Health Sciences;Hispanic-serving Institution;improved;Infrastructure;innovation;Institution;Intervention;Investments;Laboratories;Latinx;lectures;Location;Longevity;Malignant Neoplasms;marginalized community;member;Mentors;metropolitan;minority health;minority health disparity;Minority Health Research;Minority-Serving Institution;Mission;National Institute on Minority Health and Health Disparities;Native Americans;novel;Outcome;Pacific Island Americans;Paper;Peer Review;Policies;Population Sizes;Postdoctoral Fellow;prevent;Prevention;Prevention strategy;Process;Productivity;professor;programs;Public Health;Public Health Informatics;Publications;Research;research faculty;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;Scientist;Secure;Self Efficacy;Series;Services;success;Support Groups;Techniques;Technology Transfer;Training;Trust;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;vulnerable community;Vulnerable Populations

PROJECT_TITLE: HEALTH Center for Addictions Research and Cancer Prevention


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The hypothalamic hypocretin (Hcrt) neurons play a central role in integrating sensory and physiological information to tune arousal-related behavioral states, and deficiencies in these circuitries contribute to a variety of neuropsychiatric disorders. In this collaboration between researchers studying arousal-related behavioral states and BRAIN tool developers we will utilize novel interventional tools for changing neural circuit dynamics to elucidate the hierarchical organization of Hcrt circuits with respect to arousal and reward. Our exploratory studies will drive translational progress toward optimization of treatments and potential novel therapeutic opportunities in substance abuse, eating and panic disorders, cognitive disruption and emotion-related disorders, while at the same time addressing basic questions of neural circuit function underlying behavior relevant to both NINDS and NIMH.

PI_NAMEs: DE LECEA, LUIS ;HOCHGESCHWENDER, UTE H (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Acute;Address;Arousal;Award;Behavior;Behavioral;Biomedical Research;career;career development;Cognitive;Collaborations;Data;Data Analyses;Disease;Dissection;Eating Disorders;efficacy evaluation;efficacy testing;Electrophysiology (science);Emotions;Ensure;experience;experimental study;extracellular;Fostering;Foundations;Future;Goals;hypocretin;Hypothalamic structure;in vivo;Injections;interest;Intervention;Lateral;locus ceruleus structure;meetings;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;neural circuit;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;novel;novel strategies;novel therapeutics;Panic Disorder;parent grant;parent project;Phase;Physiological;Play;postsynaptic;Research;Research Personnel;Research Training;Rewards;Role;sensory integration;Solid;Substance abuse problem;System;Time;tool;Training;translational progress;treatment optimization

PROJECT_TITLE: Functional circuit dissection of the Hcrt system - Diversity Supplement Kennedy


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Emphysema;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Pulmonary Fibrosis

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Chronic obstructive pulmonary disease (COPD) and emphysema are, jointly, the fourth leading cause of death in the United States and third leading cause globally. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study found that emphysema measured quantitatively on computed tomography (CT) is common and morbid among older adults in the general population; however, standard measures underestimate the complexity of the disease. In this renewal, we hypothesize that machine-learned CT emphysema subtypes are distinct, have different causes and prognoses, and that distinguishing pathological emphysema from that resulting from normal aging with help the prevention and treatment of COPD and emphysema.

PI_NAMEs: BARR, R GRAHAM (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Age;aging population;ambient air pollution;Benign;Black Populations;Blood;Blood Cells;causal variant;Cause of Death;cell type;Cells;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Copper;Data;Diffuse;Disease;disorder subtype;Dust;Elderly;Endothelium;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epithelial Cells;Epithelium;Ethnic Origin;Ethnic Population;Evaluation;Gene Expression;Gene Expression Profile;General Population;Genetic Risk;genomic locus;Genomics;Hair follicle structure;heart function;Hospitalization;idiopathic pulmonary fibrosis;innovation;insight;Lung;Machine Learning;Measures;men;Methods;Minority;Molecular Analysis;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Nasal Epithelium;non-smoker;normal aging;Nose;novel;Occupational Exposure;older adult;Oxygen;ozone exposure;Participant;Pathologic;Phenotype;Physiology;population based;Prevalence;Prevention;Prognosis;Pulmonary Emphysema;Pulmonary Fibrosis;Quantitative Trait Loci;Race;racial population;Reproducibility;Respiratory Disease;Risk;Risk Factors;Sampling;Scanning;Senility;sex;Smoker;Smoking;Smoking History;Spirometry;standard measure;Testing;Tetraodontidae;Therapeutic;transcriptome sequencing;United States;unsupervised learning;Vascular Diseases;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Precision phenotyping of emphysema in the elderly: the MESA Lung Study

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Cannabis use and schizophrenia are closely linked – individuals at genetic risk for schizophrenia are more likely to use cannabis, which intensifies their symptoms, while cannabis users are at increased risk for the development of schizophrenia. This project will seek to disentangle these relationships by examining how the brain receptors for cannabis are altered by schizophrenia and by cannabis use. Together, these findings can provide insights into the specific types of interventions that may benefit these patient populations, and aid in the identification of novel treatments.

PI_NAMEs: CHOU, SHINN-YI  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Abnormal Cell;Acute;Autopsy;Biology;Biometry;Brain;brain tissue;Brodmann's area;Cannabis;cell cortex;CNR1 gene;cohort;comorbidity;comparison control;Complex;Confocal Microscopy;Data Set;design;Development;Diagnosis;Dose;Drug usage;Equilibrium;Female;Functional disorder;Funding;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Gene Transfer;General Population;Genetic;Genetic Risk;Glutamates;Homologous Gene;Human;Immunohistochemistry;Impairment;in vivo;Individual;Infusion procedures;insight;Intervention;Intravenous;knock-down;Knowledge;Label;Learning;Ligands;Link;male;marijuana use;marijuana user;Mass Spectrum Analysis;Mediating;Memory impairment;Mendelian randomization;novel;overexpression;Pathology;patient population;Patient-Focused Outcomes;pharmacologic;Phosphopeptides;phosphoproteomics;Phosphorylation;Pilot Projects;preclinical study;Prefrontal Cortex;Presynaptic Terminals;Prognosis;programs;Rattus;receptor;receptor expression;Receptor Signaling;recreational drug use;Research;Risk;risk sharing;RNA;Rodent;Role;Saline;Sampling;Schizophrenia;schizophrenia risk;Self Administration;sex;Short-Term Memory;Signal Transduction;skills;symptomatic improvement;Symptoms;Testing;Tetrahydrocannabinol;THC exposure;Therapeutic;Training;Translating;translational study;United States National Institutes of Health;vector control;Viral

PROJECT_TITLE: Terminal type-specific cannabinoid CB1 receptor alterations in schizophrenia and cannabis use

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Youth overdose deaths have continued to climb in recent years. Effective, evidence-based overdose prevention interventions have primarily been developed and implemented for adults and there is a significant gap in our understanding of how youth understand overdose risk and effective strategies to reduce their risk. We will engage adolescents and young adults, parents, youth providers, pharmacists, and people who use drugs to generate timely knowledge to guide future intervention development and adaptation to reduce youth overdose risk.

PI_NAMEs: BAGLEY, SARAH M (contact);GREEN, TRACI C

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Adolescent;adolescent alcohol and drug use;Adolescent and Young Adult;adolescent drug use;Adolescent Risk Behavior;adolescent substance use;Adult;Age;age group;Antidotes;Articulation;Awareness;Behavior;Cessation of life;Communities;community engagement;community partners;cost effective;Data;Decision Making;demographics;design;Drug toxicity;Drug usage;Drug user;Educational Materials;Effectiveness;empowerment;evidence base;Evidence based intervention;falls;Family;Family member;Fatality rate;Fentanyl;fentanyl test;fentanyl use;Focus Groups;Future;Goals;Harm Reduction;HIV;Home;insight;Intervention Studies;Interview;Knowledge;Life;Location;Marketing;Massachusetts;Measures;Methods;Morality;Naloxone;naloxone dispensing;Nurses;opiate tolerance;Opioid;opioid overdose;Overdose;overdose death;overdose education;overdose prevention;Overdose reduction;overdose risk;Parents;Pattern;Perception;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;pill;Prevalence;Prevention education;Prevention strategy;preventive intervention;protective behavior;Provider;Public Health;Qualitative Methods;recruit;Research;response;Rhode Island;Risk;Risk Behaviors;Risk Factors;risk mitigation;risk perception;Safety;Series;Services;Shapes;skills;social media;Social Workers;substance use;Surveys;synthetic opioid;test strip;Testing;theories;therapy development;Time;tool;trend;Trust;United States;uptake;Visualization;Xylazine;young adult;Youth

PROJECT_TITLE: The Youth Empowerment Study (YES)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-E (O1)]


NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: STONY BROOK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE Opioid analgesics are commonly used by HIV/AIDS patients for pain control, but their chronic use may lead to paradoxical pain. This project will help us improve the understanding of the underlying pathogenic mechanism and facilitate the development of effective intervention.

PI_NAMEs: TANG, SHAO-JUN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Animal Experiments;Anti-Retroviral Agents;Astrocytes;Atlases;behavior test;Cell Nucleus;cell type;Cells;Chronic;conditional knockout;Control Animal;cytokine;Data;Development;dorsal horn;dosage;effective intervention;Experimental Designs;Genes;glial activation;Glial Fibrillary Acidic Protein;HIV;HIV Envelope Protein gp120;HIV-1;HIV/AIDS;Hyperalgesia;improved;Inflammasome;inhibitor;Interleukin-1 beta;Intraperitoneal Injections;Intrathecal Injections;ITGAM gene;Knock-out;Knockout Mice;Macrophage;Maps;Measures;Microglia;Molecular;Morphine;mu opioid receptors;Mus;neural circuit;neuroinflammation;Neurons;neurotransmission;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;Pain;Pain management;pain model;pain processing;Pathogenesis;Pathogenicity;Patients;Pattern;Phenotype;Play;Posterior Horn Cells;postsynaptic;Protein Secretion;receptor;Role;side effect;Signal Transduction;Signaling Protein;Spinal;Spinal Cord;Spinal cord posterior horn;Synaptic plasticity;Testing;transcriptome sequencing;Work

PROJECT_TITLE: The spinal cell atlas of opioid-targeted inflammasomes in the HIV pain model: mechanism and pathogenic role

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative: C-C Bond formation is central to chemical synthesis. We have pioneered a broad, new family of metal-catalyzed carbonyl reductive couplings that exploit feedstock pronucleophiles in combination with safe, inexpensive feedstock reductants (H2, 2-PrOH, HCO2H), and related H2-autotransfer processes (ROH = reductant & proelectrophile) that directly convert lower alcohols to higher alcohols. In the proposed funding period, this reactivity pattern will be extended to couplings of α-olefins and C-X pronucleophiles, the use of amine proelectrophiles, the formation of quaternary stereocenters and use of base metal catalysts.

PI_NAMEs: KRISCHE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Catalytic C-C Bond Forming Hydrogenations

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Pediatric;Rehabilitation;Substance Misuse;Therapeutic Cannabinoid Research;Underage Drinking

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Most adolescents in treatment for alcohol use disorder and co-occurring disorders (AUD+CODs) use cannabis, yet little is known about the impact cannabis use has on AUD+COD treatment processes and outcomes. Consistent with NIAAA’s strategic plan to improve AUD+COD treatment, this K23 will use mixed methods to prioritize and understand adolescents’ experiences using cannabis in the context of community-based treatment for AUD+CODs, elucidate the dynamic effects of cannabis on treatment processes as they unfold when adolescents are using cannabis in their natural environments, and provide preliminary data on cannabis- related predictors of longer-term AUD+COD treatment outcomes. Results will inform productive and meaningful cannabis-related targets for AUD+COD treatment and inform models of addressing polysubstance use in treatment.

PI_NAMEs: WYCOFF, ANDREA M. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Abstinence;addiction;Address;Adolescent;Adolescent marijuana use;adolescents with alcohol use disorders;Adult;Affect;Aftercare;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol use disorder;Alcohols;Ambulatory Care;Area;Cannabis;cannabis cue;Career Mobility;Caring;Clinical Research;Clinical Trials;Communities;community based care;community based treatment;craving;Data;Development;dual diagnosis;Ecological momentary assessment;Environment;Equation;experience;Feedback;follow-up;Funding;Future;Grain;high risk;improved;inclusion criteria;Individual;interest;Intervention;Interview;Link;Literature;Lived experience;Longitudinal Surveys;Maintenance;marijuana use;marijuana use disorder;Mediator;Mental disorders;Mentorship;Methods;Modeling;Motivation;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;neglect;Outcome;outpatient programs;Participant;peer;Perception;Persons;polysubstance use;Population;Prevalence;Process;Productivity;Protocols documentation;recruit;Research;Research Methodology;Risk;Risk Factors;Sampling;Science;Statistical Models;Strategic Planning;Structure;substance use;substance use treatment;Surveys;Symptoms;Testing;Time;Training;Treatment outcome;underage drinking;Youth

PROJECT_TITLE: Effects of cannabis use on community-based alcohol treatment outcomes in adolescents

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Breast cancer survivors are the largest group of cancer survivors and are at high risk for unemployment, especially health disparity populations, leading to financial toxicity and poor health outcomes. Despite the numerous benefits of employment for cancer survivors, cancer-related fatigue and cognitive impairment are common barriers to working; these barriers can be alleviated with physical activity, but discrimination and accessibility to exercise opportunities often experienced by Black cancer survivors living in the rural south can adversely impact these outcomes. This study proposes an innovative approach to explore the relationship between physical activity and work disparities, and the impact of fatigue, cognitive limitations, discrimination, and accessibility to exercise opportunities, and gain preliminary information to develop a future intervention targeting physical activity and work-life barriers in breast cancer survivors at risk of unemployment and physical inactivity.

PI_NAMEs: ALLEN, JAIMI LOUISE (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adherence;Adverse event;adverse outcome;African American;Area;Arkansas;Attention;behavioral health;behavioral outcome;Behavioral Research;Black race;black women;Breast Cancer survivor;cancer diagnosis;cancer health disparity;Cancer Intervention;Cancer Survivor;Cancer Survivorship;cancer therapy;Career Mobility;Cognition;Cognitive;cohort;Communities;Community Health;Coupled;Data;Discrimination;Disparity;Educational Status;Elements;Employment;Environment;Equation;ethnic minority;Exercise;experience;Fatigue;fighting;financial toxicity;Foundations;Future;Goals;hands-on learning;Health;Health behavior and outcomes;health disparity populations;health inequalities;Health Insurance;High Prevalence;high risk;Hour;Impaired cognition;improved;Income;Individual;innovation;Intervention;Interview;Life;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediation;Mediator;Mentors;Modeling;National Institute on Minority Health and Health Disparities;Outcome;perceived discrimination;Performance at work;Physical activity;physical inactivity;poor health outcome;Population;programs;Qualitative Research;Quality of life;Race;racial minority;Recording of previous events;Recovery;Reduce health disparities;Research;Research Personnel;Risk;Role;Rural;rural area;Rural Community;rural dwellers;rural underserved;Security;skills;Social Behavior;social health determinants;socioeconomic disadvantage;Structure;survivorship;therapy design;Time;Training;training opportunity;treatment adherence;Unemployment;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Explaining the potential role of physical activity in employment disparities after breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Compared to non-Hispanic White women, Black women have a 41% higher mortality rate and experience worse psychosocial outcomes, including greater psychological distress and lower health related quality of life (HRQOL). Aligned with the NINR’s research lenses of health equity and social determinants of health, the proposed study will examine the feasibility, acceptability, and preliminary efficacy of a collaboratively and iteratively designed and refined peer-led support intervention to reduce psychological distress and improve HRQOL among Black breast cancer survivors. Findings will lay the groundwork to test the intervention’s efficacy in a fully powered randomized controlled trial (RCT).

PI_NAMEs: GORMLEY, MAURADE  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: acceptability and feasibility;Address;anti-cancer research;arm;Behavior;Belief;Biological;Black race;black women;Breast Cancer survivor;cancer care;cancer survivorship care;Cessation of life;Chaplain;Characteristics;Client satisfaction;Clinical Trials Design;Collaborations;Communities;community advisory board;community engagement;comparison control;coping;Data;Death Rate;design;Detection;Development;Discrimination;Disease;Disparity;Distress;Education;efficacy testing;Emotional;Equity;Event;experience;Exposure to;Financial Hardship;Focus Groups;Funding;Future;Genetic Transcription;Goals;Health;health disparity;health equity;health inequalities;health related quality of life;Healthcare;improved;Income;Individual;Intervention;intervention delivery;intervention refinement;Interview;iterative design;Knowledge;Life;Life Cycle Stages;Lived experience;Malignant Breast Neoplasm;Manuals;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;motivational enhancement therapy;Neighborhoods;Not Hispanic or Latino;Nurses;Oncology Nurse;Online Systems;Participant;peer;peer support;Phase;post-traumatic stress;Poverty;protective factors;psychological distress;Psychosocial Assessment and Care;psychosocial outcome;racial discrimination;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;resilience;retention rate;Role;Sample Size;Sampling;Scientist;screening;Secure;Sexual Health;Shapes;Signal Transduction;skills;social health determinants;social stigma;Social support;Social Workers;Spirituality;Stress;Support Groups;Supportive care;Testing;therapy development;Thermometers;Training;Training Support;Trauma;Treatment Efficacy;White Women;willingness;Work

PROJECT_TITLE: Peer-Led Support Intervention for Black Breast Cancer Survivors

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (90)]