ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: NIH SEPA Project Narrative The University of New Hampshire, in collaboration with faculty participants from the New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE), as well as school district and industry partners, propose an NIH Science Education Partnership Award to establish and advance NH CREATES the Future: the NH Collaborative for Regenerative Medicine Education and Training for Engineers and Scientists of the Future (hereafter, NH CREATES). This combination of stakeholder relationships and their activities, including teacher professional development and youth STEM projects, will establish an innovative ecosystem in New Hampshire that facilitates entry and retention of students in a biomedical education pipeline spanning middle school to higher education. This pipeline provides entry into the workforce critical to NH’s regenerative medicine, biofabrication and biotechnology needs, so that, in turn, this burgeoning industry can fulfill its potential to not only cure significant disease, but in time, evolve into that disruptive innovation that will transform medicine.

PI_NAMEs: AMATO-WIERDA, CARMELA  (contact);THOMAS, W KELLEY

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Administrator;Award;Awareness;biofabrication;Biology;Biomedical Research;Biotechnology;Career Choice;Cellular biology;Collaborations;Communities;Competence;Computing Methodologies;Dedications;Development;Disease;Ecosystem;Education;education pathway;Educational Curriculum;Educational process of instructing;Electronic Medical Records and Genomics Network;Employment;Engineering;Evolution;experience;Faculty;Future;Goals;high school;High School Faculty;higher education;Industry;industry partner;Infrastructure;innovation;Institution;junior high school;Laboratories;Learning;lens;Medical;Medicine;Mentors;Middle School Faculty;model organism;Molecular Biology;Molecular Structure;Natural regeneration;New Hampshire;Occupations;Organism;Outcome;Parents;Participant;Pathway interactions;peer coaching;programs;project-based learning;regenerative biology;Regenerative Medicine;Reporting;Research Personnel;Resources;responsible research conduct;school district;School Teachers;Schools;science education;Scientist;skills;Structure;student retention;Students;summer program;Talents;teacher;Teacher Professional Development;Time;Training;Training and Education;United States National Institutes of Health;Universities;Workforce Development;workforce needs;Youth

PROJECT_TITLE: NH CREATES the Future: The New Hampshire Collaborative for Regenerative Medicine Education and Training for Engineers and Scientists of the Future

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Colleges and universities across South Carolina have come together in the SC INBRE network to advance biomedical research by addressing the need for increased understanding of, and treatment options for, many human diseases while training the next generation of biomedical scientists. SC INBRE creates research training opportunities for undergraduate students at institutions across South Carolina and provides underrepresented minority and underprivileged students biomedical research experience aimed at promoting increased diversity in the biomedical workforce. With the changing demographics in our state and country, engaging a diverse undergraduate student population in biomedical research will ensure a well-educated workforce of physicians, scientists, health-care providers and other professionals prepared to address the current and future health care problems in America.

PI_NAMEs: GOLDSMITH, EDIE C (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Area;Award;Big Data;Biochemistry;Bioinformatics;bioinformatics tool;Biomedical Engineering;Biomedical Research;biomedical scientist;career;Cells;Collaborations;college;Country;demographics;Development;disadvantaged student;economic disparity;Educational workshop;Enrollment;Ensure;experience;Extramural Activities;Faculty;faculty support;Female;Fostering;Funding;Funding Opportunities;Future;Geographic Distribution;Geography;Goals;graduate school;Growth;Health;Health Personnel;Health Professional;Healthcare;High School Faculty;Historically Black Colleges and Universities;human disease;Industry;Institution;inter-institutional;interest;male;Medical;member;Mentors;Military Personnel;Modeling;Molecular Biology;Neurosciences;next generation;Occupations;outreach;outreach program;Paper;personalized medicine;Phase;Physicians;Pilot Projects;Population;Presbyterian Church;programs;Publications;Publishing;Regenerative Medicine;Research;Research Infrastructure;Research Project Grants;Research Training;role model;Schools;Scientist;Solid;Source;South Carolina;student training;Students;success;Teacher Professional Development;Time;Training;training opportunity;Translating;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved area;underserved students;Universities;university student;Woman;Work

PROJECT_TITLE: South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative  Loss of language function (aphasia) due to a stroke has an enormous impact on quality of life and mental health. While some individuals with post-stroke aphasia recover a great deal of their language function, many do not, and the factors leading to these differences in outcomes is not fully understood. In this study we will use network theory and dynamic functional connectivity analyses to better understand how (1) reorganization of connections in the brain and (2) differences in moment-to-moment fluctuations of brain connections lead to differences in language recovery outcomes.

PI_NAMEs: FALCONER, ISAAC B (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;Aftercare;Age;analytical tool;Aphasia;aphasia recovery;Basic Science;Boston;Brain;Brain Injuries;Brain region;career;Chronic;Chronic Phase;clinical practice;Communication;Computer Models;Data;Development;diagnostic biomarker;Experimental Designs;Fellowship;Functional Magnetic Resonance Imaging;Goals;Graph;graph theory;improved;Individual;insight;Language;language impairment;Language Therapy;Lead;Measurement;Measures;Mediating;Mental Health;Mentors;Modeling;Names;neuroimaging;Neuronal Plasticity;organizational structure;Outcome;Patients;Pattern;Persons;Physicians;post stroke;pre-doctoral;Prediction of Response to Therapy;Prognosis;Prognostic Marker;prognostication;Quality of life;Recovery;Rest;Scanning;Scientist;sex;Signal Transduction;Stroke;stroke patient;stroke recovery;stroke-induced aphasia;Structure-Activity Relationship;targeted treatment;Techniques;Testing;theories;Time;tool;Training;Treatment outcome;treatment response;Universities;Variant

PROJECT_TITLE: Dynamic functional network connectivity and neuroplasticity in post-stroke aphasia


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Area;Bioinformatics;Biomedical Research;career;career development;Collaborations;college;Communication;Development;Educational workshop;Effectiveness;Ensure;Environment;Evaluation;experience;Faculty;Fostering;Funding;Geographic Distribution;Goals;high school program;High School Student;Institution;Leadership;Logistics;member;Monitor;outreach;Participant;Phase;Pilot Projects;Play;Population;Presbyterian Church;Program Research Project Grants;programs;Research;Research Project Grants;Research Training;Role;science teacher;South Carolina;Structure;student training;Students;success;teacher;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved students;Universities;Work

PROJECT_TITLE: SC INBRE Administrative Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Tumors are often kept in check by the immune system, however, because tumors are made of our own tissue, this sometimes results in autoimmune reactions against our healthy tissue called paraneoplastic syndromes that are quite common and can affect the brain, with devastating consequences. This project examines the role of KIR and HLA in these complications, in the hope they can be stopped or prevented. This project is also important for cancer patients treated by immunotherapy, as these poorly understood complications often emerge as a result of these treatments.

PI_NAMEs: MIGNOT, EMMANUEL J (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;Aftercare;Age;Age of Onset;Alleles;amphiphysin;Antigens;Area;Autoantibodies;Autoimmune;B-Lymphocytes;Brain;cancer immunotherapy;Cancer Patient;Central Nervous System;Cerebellar Ataxia;Clinical;Clinical Data;CNTNAP1 gene;Communicable Diseases;Complement;Complex;Country;CSF1 gene;Data;Data Set;Databases;Demyelinating Diseases;Disease;DNA;dosage;Encephalitis;Ethnic Origin;Exclusion;Frequencies;Functional disorder;GEM gene;Gene Dosage;Gene Frequency;Gene Modified;Genes;Genetic;Genetic Polymorphism;genome wide association study;genome-wide;genome-wide analysis;Genotype;Haplotypes;Herpes encephalitis;Heterogeneity;Immune system;Immunotherapy;In Vitro;Lambert-Eaton Myasthenic Syndrome;LGI1 gene;Ligands;Limbic Encephalitis;Literature;Malignant Neoplasms;Mediating;Modeling;Multiple Sclerosis;Myasthenia Gravis;Narcolepsy;Natural Killer Cells;Nature;Nervous System Paraneoplastic Syndromes;Neuroimmune;neuroimmunology;Neurology;Neuromyelitis Optica;next generation sequencing;novel;Nucleotides;Outcome;Ovarian Teratoma;Paraneoplastic Syndromes;Parkinson Disease;Pathology;Peripheral Nervous System Diseases;Plasma;prevent;Rare Diseases;Reaction;Reporting;Research;Research Personnel;Resolution;Role;sample collection;Sample Size;Sampling;Serum;Severity of illness;sex;Signal Transduction;Single Nucleotide Polymorphism;Stiff-Person Syndrome;Stratification;Surface;Surveys;symptom cluster;Symptoms;Syndrome;T-Lymphocyte;Techniques;Testing;Tissues;treatment response;tumor;Tumor Immunity;Update;Work

PROJECT_TITLE: KIR and HLA effects in CNS paraneoplastic syndromes and related neuroimmune conditions


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Genetics;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PI_NAMEs: LASKIN, JEFFREY D (contact)

PROJECT_TERMS: Acceleration;adduct;Adenine;Alkylating Agents;Amifostine;Antibiotics;Apical;Apoptosis;ataxia telangiectasia mutated protein;ATM activation;ATR gene;Basal Cell;base;Basement membrane;Bulla;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Physiology;Cell Survival;Cells;Characteristics;CHEK1 gene;CHEK2 gene;chemical synthesis;Chemical Warfare;crosslink;Cytoprotection;cytotoxic;cytotoxicity;Dermal;Development;distinguished professor;DNA;DNA analysis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Modification Process;DNA Repair;DNA Repair Gene;DNA Replication Inhibition;DNA strand break;DNA-dependent protein kinase;DNA-PKcs;Doctor of Philosophy;Double Strand Break Repair;drug action;Drug Approval Processes;epidermis cell;Epigenetic Process;Exposure to;FDA approved;Fluoroquinolones;genetic regulatory protein;Genetic Transcription;genome integrity;genotoxicity;Goals;Grant;Guanine;H2AFX gene;histone modification;Human;Human Resources;in vivo;Investigation;keratinocyte;macromolecule;Mechlorethamine;Mediating;mid-career faculty;Modification;Mus;Mustard;Mustard Gas;Mutation;new therapeutic target;Nitrogen;novel;Nucleic Acids;Organophosphates;Pathway interactions;Pharmaceutical Preparations;Pharmacy Schools;Phosphorylation;Phosphotransferases;PIK3CG gene;Process;Prodrugs;Proliferating;Proteins;Public Health Schools;Radiation therapy;Reaction;recruit;repaired;replication factor A;Reporting;Research Project Grants;response;Role;sensor;Side;Signal Induction;Signal Pathway;Signal Transduction;Single-Stranded DNA;Site;Skin;Skin injury;Tail;Time;Tissues;Toxic effect;TP53 gene;Transcription Coactivator;Universities;Vesicants

PROJECT_TITLE: Research Project I - Vesicant-Induced Skin Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-B]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Human Genome

PI_NAMEs: VALAFAR, HOMAYOUN  (contact)

PROJECT_TERMS: Adopted;Area;Attention;Bioinformatics;bioinformatics tool;Biological Sciences;Biomedical Research;Collaborations;comparative genomics;Course Content;Custom;Data Analyses;data hosting;Data Storage and Retrieval;data warehouse;Dedications;Development;Discipline;distributed model;DNA Sequence Alteration;educational atmosphere;Educational Curriculum;Educational workshop;Experimental Designs;Extramural Activities;Faculty;faculty mentor;Feedback;Fostering;Foundations;Funding;Genome;Genomics;Goals;Grant;Growth;Human Resources;Infrastructure;Institution;Instruction;instrumentation;interest;Library Services;meetings;member;Methods;Modeling;Modernization;Molecular Biology;multidisciplinary;Nature;Online Systems;personalized medicine;Phase;Pilot Projects;Proteomics;recruit;Research;research facility;Research Personnel;Research Project Grants;Resources;Secure;Services;South Carolina;Structure;student training;Students;Tissue-Specific Gene Expression;tool;Training;transcriptome;undergraduate student;Visit;web site;Writing

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PROJECT_TERMS: Area;Award;base;Biochemistry;Bioinformatics;Biomedical Engineering;Biomedical Research;career;career development;Career Mobility;Cellular biology;Centers of Research Excellence;Collaborations;Communication;Counseling;Development;Educational workshop;Eligibility Determination;Ensure;Evaluation;experience;Faculty;Funding;Funding Opportunities;Goals;graduate student;Growth;Institution;interest;Leadership;member;mid-career faculty;Molecular Biology;Monitor;Nature;Neurosciences;outreach;Performance;Process;Program Research Project Grants;programs;Recommendation;Regenerative Medicine;Research;research and development;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Review Committee;South Carolina;stem;student training;Students;success;Teacher Professional Development;tenure track;Time;tool;Training;training opportunity;trend;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Developmental Research Project (DRP) Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PI_NAMEs: GORDON, MARION K (contact)

PROJECT_TERMS: Advanced Development;Basement membrane;Blindness;Bulla;cell motility;cell type;Cells;Chronic Disease;Collagen;Collagen Type XVII;Cornea;corneal epithelium;Corneal Injury;corneal regeneration;Cyclophilin A;Cyclosporine;Deposition;Doctor of Philosophy;Doxycycline;Drug usage;Dry Eye Syndromes;Emulsions;Endopeptidases;Epithelial Attachment;Epithelial Cells;epithelial injury;Epithelium;Excision;experimental study;Exposure to;Extracellular Matrix;Extracellular Space;Eye;eye dryness;FDA approved;Fibronectins;Fibrosis;Gelatinase B;Glycoproteins;Grant;hevin;Human;Immunosuppressive Agents;Impaired healing;Impaired wound healing;Individual;Inflammatory;Injury;Integrin alpha6beta4;Lead;Lesion;Ligands;Lipid Peroxidation;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechlorethamine;Mediating;MMP9 gene;Modeling;Mustard;Mustard Gas;nanomolar;Organ Culture Techniques;Oryctolagus cuniculus;Oxidants;Oxidative Stress;Oxidative Stress Induction;Oxytetracycline;Pathology;Peptide Hydrolases;Peptidylprolyl Isomerase;Pharmaceutical Preparations;pre-Investigational New Drug meeting;Process;Production;Proteins;Research Personnel;Research Project Grants;response to injury;Structure;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;TNF-alpha converting enzyme;Toxic effect;Universities;Up-Regulation;vapor;Vesicants;wound;wound bed;wound healing

PROJECT_TITLE: Research Project II - Vesicant-Induced Corneal Injury


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: In patients receiving deep brain stimulation for treatment of epilepsy the majority see significant improvement, but few actually achieve seizure freedom. These stimulators have many possible settings, but there is no systematic method of setting them and it is unlikely that they are providing the maximum possible benefit. This research will develop a process for selecting settings for deep brain stimulation treatment of epilepsy based on neural signals to improve efficacy of this therapy.

PI_NAMEs: MCGOVERN, ROBERT A (contact);NETOFF, THEODEN I

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Algorithms;Animal Model;Anterior;Binding;Biological Markers;biomarker discovery;biomarker validation;Cell Nucleus;Clinic;Clinical;Clinical Trials;Computer Analysis;Computer Models;Computers;Data;data streams;Deep Brain Stimulation;density;Development;diaries;Disease;efficacy trial;Epilepsy;epileptiform;Event;Excision;Freedom;Frequencies;Goals;Home;Implant;implantable device;improved;individualized medicine;innovation;Link;machine learning algorithm;Measurement;Measures;Medical;Mental Depression;Methods;Modeling;Monitor;neural;neural implant;neurotransmission;operation;Operative Surgical Procedures;Outcome;Pain;Parkinson Disease;Patients;Phase;Physicians;Physiologic pulse;Process;Randomized, Controlled Trials;Recommendation;Refractory;Research;response;safety and feasibility;Schedule;secondary outcome;Seizures;Signal Transduction;Stream;System;Testing;Thalamic structure;Time;Traumatic Brain Injury;Treatment Efficacy;Validation;verification and validation;wearable sensor technology;Width;Work

PROJECT_TITLE: Patient Specific Parameter Optimization of Thalamic Stimulation for Treatment of Epilepsy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE H3.3-G34R mutation occurs in 15% of pediatric high-grade gliomas (pHGGs), and due to a lack of proper in vivo models that fully recapitulate the genetic and histopathological features of pHGGs, no advanced therapy for this deadly disease has been developed in the last 3 decades. We have generated a genetically engineered mouse model with a conditional knock-in allele of the H3.3-G34R point mutation on the backdrop of ATRX- and Trp53- loss, which develop pHGGs exhibiting human H3.3-G34R mutant glioma features. In this study, we propose to elucidate the mechanisms by which H3.3-G34R mutation and ATRX deletion modulate cell fate switch in gliomagenesis, which would provide insights into developing novel therapeutic strategies for pHGGs and other cancers that frequently harbor H3.3 and ATRX mutations.

PI_NAMEs: HU, JIAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Age;Alleles;ATRX gene;Automobile Driving;Brain;Brain Neoplasms;Cells;Childhood Brain Neoplasm;Childhood Glioma;Deposition;Development;Diagnosis;Disease;effective therapy;Ensure;Epigenetic Process;epigenetic regulation;epigenome;Exhibits;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Genomic Instability;Glioma;Gliomagenesis;Goals;Histone H3.3;histone modification;Histones;Human;Impairment;in vivo Model;insight;Knock-in;Knowledge;loss of function mutation;Malignant Neoplasms;Mediator;Mitochondria;Molecular;Molecular Chaperones;mutant;Mutate;Mutation;neoplastic cell;nerve stem cell;neuroblast;neuron development;Neuronal Differentiation;Neurons;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;Patients;Pediatric Neoplasm;Point Mutation;Post-Translational Protein Processing;premalignant;prevent;Prognosis;Reactive Oxygen Species;Role;Shapes;Solid Neoplasm;Switch Genes;telomere;Testing;Therapeutic;therapeutic development;therapeutic target;tool;transcription factor;tumor;Tumor Promotion;United States;Up-Regulation

PROJECT_TITLE: Investigating the role of dysfunctional histone H3.3 in driving early neuronal development and pediatric high-grade gliomas

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: LASKIN, DEBRA L (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Advanced Development;Anti-Inflammatory Agents;Antibodies;bile acid metabolism;Bile Acids;blood glucose regulation;chemical threat;Chronic Disease;Chronic Lung Injury;cytokine;cytotoxic;Development;Doctor of Philosophy;drug development;Drug Targeting;Exposure to;Funding;gene product;Grant;Impaired wound healing;Impairment;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;insight;Lead;Ligands;Link;Lipids;Lung;lung injury;Macrophage;Macrophage Activation;Mechlorethamine;Mediating;Mediator;MicroRNAs;Morbidity - disease rate;mortality;Mustard;Mustard Gas;Nitric Oxide;NOS2A gene;novel;novel therapeutics;NR4A1 gene;Nuclear Receptors;Pathogenicity;Pathology;Pharmacologic Substance;Phenotype;Poisoning;Process;Production;Proteins;Pulmonary Fibrosis;Pulmonary Inflammation;Reactive Nitrogen Species;receptor;Research Personnel;Research Project Grants;Respiratory System;response;Signal Pathway;Signal Transduction;Testing;Therapeutic;therapy development;tissue injury;Tissues;TNF gene;Toxic effect;transcription factor;Universities;vesicant induced lung injury;Vesicants

PROJECT_TITLE: Research Project III - Vesicant-Induced Lung Injury


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Correlative measures of clinical tumor behavior for targeted, immune and cell based therapies in lung cancer are required for optimal treatment plans. A liquid biopsy of the lung using bronchoalveolar lavage (BAL) can augment tumor and blood immunogenomic profiling but pre-analytic variables will alter results. We propose experiments herein to standardize collection and processing of BAL for the immunogenomic profiling of lung cancer.

PI_NAMEs: HOUGHTON, A MCGARRY;NAIR, VISWAM SIVA (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Affect;aspirate;Attention;biobank;Biological Assay;Biological Markers;Biopsy;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cancer Biology;cancer biomarkers;cancer diagnosis;cancer genome;Cancer Patient;cancer therapy;Caring;Cell Culture Techniques;cell dimension;cell free DNA;Cell Therapy;cell type;Cells;Cellular Assay;Chest wall structure;Clinic;Clinical;clinical practice;Clinical Trials;clinically relevant;Collection;Companions;Cryopreservation;Cytology;Data;design;Detection;Diagnosis;Diagnostic;DNA;early phase clinical trial;Enrollment;Epidermal Growth Factor Receptor;exhaust;experimental study;Exposure to;first-in-human;Flow Cytometry;Fred Hutchinson Cancer Research Center;Genes;Genome;genome analysis;genomic profiling;Genomics;Goals;Health Care Costs;high dimensionality;Immune;Immunogenomics;Immunology;Immunophenotyping;Immunotherapy;improved;innovation;Integration Host Factors;Knowledge;Laboratories;Lavage;liquid biopsy;Liquid substance;Lung;Lung Adenocarcinoma;Lung Neoplasms;Lymphocyte;Malignant neoplasm of lung;Measures;Medicine;Methods;Modernization;Molecular;Molecular Analysis;Molecular Profiling;Morbidity - disease rate;mortality;Mutation;Needles;novel;Observational Study;optimal treatments;Outcome;patient population;Patients;Physicians;Plasma;Procedures;Proteins;Protocols documentation;Provider;Pulmonary Inflammation;Recovery;Reporting;Reproducibility;Research Personnel;research study;Resected;Sampling;Specialized Program of Research Excellence;specific biomarkers;Standardization;statistics;success;Survival Rate;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Techniques;Time;Tissue Sample;Tissues;tool;treatment planning;tumor;tumor behavior;Tumor Biology;tumor diagnostic;tumor heterogeneity;Tumor Markers;tumor microenvironment;Tumor Tissue;Tumor-Derived;Variant;Work

PROJECT_TITLE: Liquid biopsy of the lung to profile lung cancer


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SANTA CRUZ

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative: Many diseases are caused by inadequate protein synthesis at the right time and in the right place including major neurological disorders, cancers, cardiovascular disease, and autoimmune diseases. Understanding how this processes works is essential to understanding human disease and developing therapeutics. Therefore, this project aims to develop a molecular picture of the function and mechanisms by which a central regulatory hub, the elongation factor 2 kinase pathway, regulates protein synthesis.

PI_NAMEs: LOERCH, SARAH  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Autoimmune Diseases;Award;Binding;Biochemical;Biophysics;calmodulin-dependent protein kinase III;Cardiovascular Diseases;cell type;Cells;Cellular biology;Communicable Diseases;Cryoelectron Microscopy;Cues;Development;Disease;Homeostasis;human disease;In Situ;Location;Malignant Neoplasms;Messenger RNA;Molecular;mRNA Decay;mRNA Stability;mRNA Translation;Nervous System Disorder;Neurologic Dysfunctions;Neurons;Neurotransmitters;novel;particle;Pathway interactions;Peptide Elongation Factor 2;Phase;Phosphorylation;Process;programs;Protein Biosynthesis;Proteins;Regulation;Research;Research Project Grants;Ribosomes;Role;Signal Transduction;Site;Specificity;structural biology;Structural Models;Synapses;Testing;Therapeutic;therapeutic target;Time;Translational Regulation;Translational Repression;Translations;Work

PROJECT_TITLE: Molecular Mechanisms of Translation Regulation by the eEF2K Pathway

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Stress-related neuropeptides are thought to participate in the transition to alcohol dependence, in part through an upregulation in their receptor gene expression. This process may be different for the stress-related neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), which is highly expressed in the paraventricular nucleus of the thalamus, is dense in projections to the nucleus accumbens, and is known to act through several different PACAP receptor variants. This proposal aims to investigate the role of PACAP and its receptor variants in the transition to alcohol dependence, with the ultimate goal of informing the development of pharmacotherapies for the treatment of alcohol use disorder.

PI_NAMEs: CARPENTER, BRODY ALLEN (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Animals;Attention;attenuation;Behavioral;behavioral response;binge drinking;Brain;Cannulas;Cells;Chronic;combat;comparative;Consumption;Corticotropin-Releasing Hormone;Coupled;Data;Dependence;designer receptors exclusively activated by designer drugs;Development;drinking;Dynorphins;Ethanol;Ethanol dependence;Exhibits;experimental study;Gene Expression;Genetic;Glutamates;Goals;GTP-Binding Proteins;Heavy Drinking;Individual;Injections;Intake;knock-down;Limbic System;Measures;Microinjections;Modeling;motivated behavior;mRNA Expression;Mus;neurochemistry;Neurons;Neuropeptides;new therapeutic target;Nucleus Accumbens;Output;PACAP27;Pathway interactions;Peptides;Pharmacotherapy;pituitary adenylate cyclase activating polypeptide;Population;Process;Protein Isoforms;Publishing;Rattus;receptor;Receptor Gene;Recording of previous events;RNA;Role;Stress;Structure of paraventricular nucleus of thalamus;System;Testing;Time;Training;Up-Regulation;vapor;Variant

PROJECT_TITLE: Receptor variant-based changes in the role of PACAP in the nucleus accumbens during the transition to ethanol dependence


NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Phase separation has recently emerged as a fundamental mechanism for spatial and functional organization that does not require internal membrane-enclosed compartments in eukaryotic cells, but phase separation in bacterial cells remains poorly understood. This project will fully characterize the phase separation of the bacterial chromosome by connecting its mechanical behavior to its molecular properties and by defining the effect of phase separation on the structure, mobility, and accessibility of bacterial chromosomes. Our work will identify the mechanism of chromosomal phase separation and its role in the ability of bacteria to survive stressful environments, providing new targets for rationally designed antibiotics.

PI_NAMEs: BITEEN, JULIE  (contact);MEYER, ANNE SARA

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Ally;antibiotic design;Automobile Driving;Bacteria;Bacterial Chromosomes;Bacterial DNA;Bacterial Physiology;Behavior;Biochemical;Biochemistry;Biogenesis;cell injury;Cell Physiology;Cell Separation;Cell Survival;Cells;chemical property;chromatin immunoprecipitation;Chromosome Condensation;chromosome conformation capture;Chromosome Structures;Chromosomes;Complement;Complex;Cytoplasm;defined contribution;Diffuse;Diffusion;DNA;DNA Binding;DNA-Binding Proteins;DNA-Directed RNA Polymerase;Engineering;Environment;environmental change;Eukaryotic Cell;experimental study;Feedback;Genetic;genome-wide;genomic locus;Goals;Growth;Higher Order Chromatin Structure;Image;in silico;In Vitro;in vivo;innovation;Kinetics;Life;liquid crystal;Liquid substance;macromolecule;Maps;Measures;mechanical behavior;mechanical properties;Mediating;Membrane;Microscopy;Mobility decline;Modeling;Molecular;Motion;multidisciplinary;novel;Nucleic Acids;Organelles;Organism;Phase;Phase Transition;Physical condensation;physical property;Physiological;Process;Property;Proteins;Proteomics;rational design;Research;response;Rheology;Ribosomes;Role;single molecule;small molecule;Spatial Distribution;Spectrum Analysis;Starvation;Stress;Structure;superresolution imaging;superresolution microscopy;System;Testing;theories;Time;tool;Trees;viscoelasticity;Work

PROJECT_TITLE: Physicochemical properties driving membraneless organelle assembly in bacteria

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Proper gene expression is crucial for cellular differentiation, development, and disease. The goal of this proposal is to determine the molecular mechanisms underlying co-transcriptional gene expression regulation in human cells and during stem cell differentiation. Our findings will uncover novel layers of gene regulation that will set the path to develop new strategies to control gene expression with therapeutic benefits.

PI_NAMEs: FISZBEIN, ANA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Affect;Architecture;Cardiac;Cell Differentiation process;Cells;Chromatin;Code;Computer Analysis;computerized tools;Coupling;design;Development;Disease;Environment;Event;Exons;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Human;Hybrids;insight;Logic;Molecular;novel;Process;Production;promoter;Regulation;Research;RNA Processing;RNA Splicing;Role;Site;Spliceosomes;stem cell differentiation;Techniques;Therapeutic;Transcript;Transcriptional Regulation;transcriptome;Work

PROJECT_TITLE: Probing co-transcriptional gene regulatory logics in human transcriptomes


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Disability Research;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Prenatal Alcohol Exposure (PAE) is a common cause of fetal growth restriction, which is a known risk factor for brain disability. The proposed studies meet a significant need for mechanism-centered diagnostics and interventions for this important pregnancy complication due to PAE and other etiologies. The goals of these studies are consistent with the goals outlined in the 2017-2021 strategic plan of the National Institute of Alcohol Abuse and Alcoholism (NIAAA), to diagnose and to treat the consequences of alcohol use and misuse, including Fetal Alcohol Spectrum Disorders (FASD).

PI_NAMEs: CHAMBERS, CHRISTINA  (contact);LAURENT, LOUISE CHANG;MIRANDA, RAJESH C

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Affect;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol misuse;Alcoholism;Alcohols;Biological;Birth;Brain;C-reactive protein;Cell Culture Techniques;Cell Line;Cells;Child;Chorionic villi;Circulation;cohort;cytokine;Cytokine Network Pathway;Data;Defect;Developmental Disabilities;Diagnosis;Diagnostic;disability;Drug or chemical Tissue Distribution;Endocrine;Epithelium;Ethanol;Etiology;Exhibits;Exposure to;extracellular;extracellular vesicles;Family;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Growth;Fetal Growth Retardation;Functional disorder;Gene Expression;Goals;Growth;Head circumference;Height;Human;Human Cell Line;Infant;inhibitor;Injections;innovation;Intervention;Invaded;Link;Lipoproteins;Long term disability;Measures;Mediating;Mediator;Mesenchymal;MicroRNAs;mimetics;Mothers;mouse model;Mus;nonhuman primate;novel;Outcome;Outcome Study;particle;Pathology;Pathway interactions;Placenta;Placental Insufficiency;placental trophoblasts;Placentation;Plasma;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;prenatal exposure;prevent;Process;Qualifying;receptor;recruit;Research Personnel;response;Review Literature;Risk Factors;Rodent;Role;Sampling;School-Age Population;Second Messenger Systems;Second Pregnancy Trimester;Signal Transduction;skills;Spontaneous abortion;Strategic Planning;Subgroup;Testing;transcriptomics;translational potential;trophoblast;Ukraine;Ultrasonography;Vascular Endothelial Growth Factors;Weight;Woman

PROJECT_TITLE: Maternal mediators of fetal growth restriction linked to prenatal alcohol exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Unstructured (free-text) clinical notes in electronic health record (EHR) systems contain valuable phenotypic, genomic, and other data needed to support cancer research ranging from identification of rare cancer cohorts to data abstraction. These notes remain underutilized, in part, because of the complexity of accessing and extracting details from the unstructured data. EMERSE (The Electronic Medical Record Search Engine), an easy-to-use, mature, information retrieval software system that is being used or implemented at research institutions across the nation, simplifies this process. The aims of this proposal are to develop novel, valuable, user-prioritized features to extend the power and reach of EMERSE, including incorporating Natural Language Processing (NLP) capabilities.

PI_NAMEs: HANAUER, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Address;Administrator;anti-cancer research;application programming interface;base;Behavioral;Cancer Center;Clinical;Clinical Research;cohort;Communities;Computer software;Computerized Medical Record;Consensus;Country;Data;data standards;data visualization;design;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease Progression;Electronic Health Record;electronic health record system;empowerment;Exclusion;experience;Family;Feedback;Funding;Future;Genomics;Goals;Grant;Hand;health determinants;Human Resources;improved;indexing;individual patient;Information Retrieval;Information Retrieval Systems;innovation;Institution;Interview;Knowledge;Lead;Leadership;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;meetings;Michigan;Mothers;Multi-Institutional Clinical Trial;Names;Natural Language Processing;novel;Ontology;operation;optical character recognition;Outcome;Pain;Pathology Report;Patients;Peer Review;Perception;Phenotype;Process;programs;rare cancer;Recording of previous events;Recurrence;Research;Research Personnel;Review Literature;Running;Scanning;search engine;Secure;Security;Semantics;Services;Site;social;social health determinants;Social Network;software systems;Structure;Surveys;System;systems research;Targeted Research;Technology;Testing;Text;text searching;timeline;tool;Toxic effect;translational cancer research;treatment response;Trust;Tumor Markers;Uncertainty;Unified Medical Language System;Universities;unstructured data;Work

PROJECT_TITLE: Extending the Capabilities and Reach of EMERSE in Support of Cancer Research


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Optical imaging allows for biological processes to be visualized in real time, providing key information on mechanisms of disease; however, its utility has been limited due to the low penetration of light through tissue. This proposal uses a special type of light (shortwave infrared) that passes through skin and tissue to allow for optical imaging in mammals. Through the development of new contrast agents, we will illuminate biology in relevant models of human disease.

PI_NAMEs: SLETTEN, ELLEN MAY (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: absorption;Animal Model;Animals;arm;Basic Science;Biological;Biological Process;Biology;biomaterial compatibility;Biopsy;cancer imaging;Cells;chromophore;Clinical;clinical application;clinical diagnostics;clinically relevant;Collaborations;Color;Contrast Media;copolymer;Custom;Detection;Development;Disease;Electromagnetics;Engineering;Environment;Excision;experimental group;experimental study;fluorophore;Formulation;Foundations;Free Energy;Gel;Goals;Grant;Human;human disease;human model;Image;Imaging Techniques;improved;in vivo;Injections;Integrins;Label;Laboratories;Lasers;Lead;Learning;Light;light scattering;Lymph;Lymph Node Mapping;lymph nodes;lymphatic drainage;lymphatic imaging;Lymphatic System;Malignant Neoplasms;Mammals;Measures;Metastatic Neoplasm to Lymph Nodes;Methods;Micelles;millimeter;Modification;Molecular;multiplexed imaging;Mus;Neoplasm Metastasis;Noise;Operative Surgical Procedures;optical imaging;Organic Chemistry;Organism;Penetration;Performance;Periodicity;Polymers;Property;real-time images;Reporting;Resolution;scaffold;Sentinel;Sentinel Lymph Node Mapping;Sepharose;Short Waves;Shortwave Infrared Imaging;Signal Transduction;Site;Skin;small molecule;System;Tail;Testing;theories;Time;Tissues;Toxic effect;tumor;Variant;Visualization;Water;Work

PROJECT_TITLE: Biocompatible fluorophores for shortwave infrared imaging

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Disease;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Our transdisciplinary study is the largest and most comprehensive study on environmental exposures and the underlying mechanisms driving NAFLD risk and NAFLD progression that result in health disparities in Latino children. We will integrate state-of-the-art omics signatures using data science approaches to identify robust molecular profiles that are associated with NAFLD across different disease progression stages. Findings will contribute evidence to inform precision prevention strategies for NAFLD in high-risk populations.

PI_NAMEs: AUNG, TUN (MAX) M;CHATZI, VAIA LIDA  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;Air Pollution;Animal Model;Automobile Driving;Behavior;Behavioral;Biological;Biological Markers;Blood;burden of illness;California;Chemicals;Child;Childhood;chronic liver disease;Cirrhosis;Clinical;Clinical Data;Cluster Analysis;Communities;Complex;Cross-Sectional Studies;Data;data integration;Data Science;Detection;dietary;Disease;disease phenotype;Disease Progression;disorder risk;Early identification;Endocrine Disruptors;Enrollment;Environment;Environmental Exposure;Environmental Pollutants;Enzymes;Epidemiology;Epigenetic Process;epigenomics;Ethnic Population;Etiology;experience;Exposure to;Extrahepatic;Family;Fatty acid glycerol esters;fatty liver disease;Feces;Fibrosis;follow-up;Funding;Genetic Predisposition to Disease;Genomics;Goals;Health;health data;health disparity;Hepatic;hepatocyte injury;high dimensionality;High Prevalence;high risk;high risk population;Human;imaging modality;improved;individualized prevention;Industrial Waste;Inflammation;innovation;insight;Investigation;Latino;Latino Population;Life Style;lifestyle factors;Lipids;Liver;liver injury;liver transplantation;Los Angeles;low socioeconomic status;Magnetic Resonance Imaging;Measurement;Measures;Mediation;Metabolic;metabolomics;metagenomic sequencing;Methodology;Methods;microbiome;Minority Groups;modifiable risk;Molecular;Molecular Profiling;Morbidity - disease rate;multidisciplinary;Multiomic Data;multiple omics;Neighborhoods;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;obesity in children;Pathology;Pathway interactions;Pediatric Hospitals;pediatric non-alcoholic fatty liver disease;Pesticides;phenotypic data;Physiological;Plasticizers;pollutant;Population;Prevalence;Prevention approach;Prevention strategy;Proteomics;Public Health;Questionnaires;racial population;recruit;Research;Research Design;Resources;response;Risk;Risk Factors;Sample Size;Severity of illness;social;social factors;social health determinants;Social status;specific biomarkers;Specimen;Subgroup;tool;Toxic Environmental Substances;toxic metal;toxicant;transcriptomics;trend;Underserved Population;Unhealthy Diet;Urine;Youth

PROJECT_TITLE: Longitudinal integration of environmental exposures, omics, and childhood NAFLD (LEON) Study


NIH_SPENDING_CATS: Natural Products

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The goal of this proposal is the development of small molecules that can control actin dynamics with light. Such molecules could serve as useful probes to study the actin cytoskeleton and form the basis of a new class of precision chemotherapeutics.

PI_NAMEs: TRAUNER, DIRK HARTWIG (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Actins;Alkynes;Allosteric Site;analog;Azides;azobenzene;Binding;Biological;blebbistatin;Cancer cell line;Cardiac;cell motility;Cell Physiology;Cells;Cellular biology;Chemicals;Clinical;Collaborations;Communities;Complex;Cryoelectron Microscopy;Cytochalasin D;Cytochalasins;Cytoskeleton;cytotoxic;Darkness;design;Development;Docking;Drug Targeting;Elongation Factor;F-Actin;Filament;Financial cost;G Actin;Glues;Goals;Grant;Halogens;Hela Cells;high throughput screening;Human;improved;in silico;inhibitor;jasplakinolide;Label;latrunculin A;latrunculin B;Length;Light;Location;Marine Toxins;Microglia;Molecular;Molecular Motors;monomer;Motor;Myosin S-2;Myosin Type II;Natural Products;Neoplasm Metastasis;Neurons;Oligodendroglia;Optics;Organelles;Parents;Pathway interactions;pharmacokinetics and pharmacodynamics;Play;Polymers;Porifera;programs;Property;Proteins;rational design;redshift;Roentgen Rays;Role;Running;small molecule;stem;Structural Biologist;structural biology;Structure;Structure-Activity Relationship;temporal measurement;Therapeutic;tool;Toxin;Tubulin;vasodilator-stimulated phosphoprotein;Visible Radiation;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Optical Control of the Actin Cytoskeleton


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Infant Mortality;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research will identify novel indicators of neonatal intestinal development and health that will enable the development of predictive algorithms to identify very preterm infants who would benefit from precision- nutrition guided interventions to prevent and treat feeding intolerance and intestinal disease.

PI_NAMEs: CHAPKIN, ROBERT STEPHEN;DONOVAN, SHARON MARIE (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Abdomen;Affect;analytical method;Antibiotics;artificial neural network;Benign;Biological Markers;biomarker identification;Caring;Cells;Characteristics;Clinical;clinical care;clinical predictors;clinically relevant;Data;Development;Developmental Biology;Diagnosis;Diet;dietary;Disease;disorder risk;early detection biomarkers;Early Diagnosis;Enteral;Enteral Feeding;Enteral Nutrition;evidence base;Exhibits;extreme prematurity;fecal microbiota;feeding;Functional disorder;gastrointestinal;gastrointestinal sign;gastrointestinal symptom;Gene Expression;Genes;Gestational Age;Growth;gut microbiome;Health;high risk;Hospitalization;host microbiome;Immune;improved;Infant;Infant Health;Inflammatory;insight;Intervention;Intestinal Diseases;intestinal injury;intestinal maturation;Intestinal Mucosa;Intestines;Ischemia;ischemic injury;Life;machine learning algorithm;Measures;medical complication;Metabolic;metabolome;metagenome;Methodology;microbial;microbiome;microbiome signature;Mucous Membrane;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;neonatal period;Neurocognitive;Normal Range;novel;novel marker;nutrition;Nutritional;Nutritional Support;Outcome;Pathologic;Pathology;Physiological;Physiology;precision medicine;precision nutrition;prediction algorithm;Premature Infant;prevent;Process;Prospective cohort;Recommendation;Research;response;Risk;Risk Factors;Route;Symptoms;Testing;Time;tool;transcriptome

PROJECT_TITLE: Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Obesity;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Metastasis is the leading cause of death in patients with advanced breast cancer and increases in frequency with obesity; however, the underlying mechanisms that cause breast cancer metastasis remain unclear. By iteratively coupling computer simulations, experiments, and advanced omics approaches, the proposed studies will improve understanding of how obesity-dependent changes in breast adipose tissue mechanical properties regulate breast cancer invasion and metastasis and link these changes to targetable cellular mechanisms. The generated new insights have the potential to decrease breast cancer burden associated with the obesity epidemic in the U.S.

PI_NAMEs: FISCHBACH, CLAUDIA  (contact);O'HERN, COREY

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;advanced breast cancer;Affect;Biochemical;Bioinformatics;biological systems;Biology;biophysical properties;Breast;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;Calibration;Cancer Burden;Cancer Prognosis;Cause of Death;Cell Culture Techniques;Cells;clinically relevant;Coculture Techniques;Computer Models;Computer Simulation;computer studies;Computing Methodologies;Coupled;Couples;Coupling;Data;Data Set;Deposition;Disparity;effective therapy;Elements;Engineering;experimental study;Extracellular Matrix;Frequencies;Gene Expression Profile;Genetic;genetic signature;Histologic;Histology;Human;improved;in vivo;Inflammatory;insight;interstitial;Invaded;Ligands;Link;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;mechanical properties;Mechanics;Methods;Modeling;Molecular;Motility;mouse model;Myofibroblast;Neoplasm Metastasis;neoplastic cell;novel;obese patients;obese person;Obesity;Obesity Epidemic;particle;Pathogenesis;Pathologic;patient prognosis;Patients;Phenotype;physical property;Play;Prevalence;Process;Prognosis;Property;receptor;risk prediction;RNA;Role;Sampling;Shapes;simulation;Specimen;Technology;Testing;Thinness;Time;Tissues;transcriptome sequencing;transcriptomics;transdifferentiation;Transgenic Mice;tumor;Tumor Cell Invasion;tumor metabolism;Tumor Promotion;Visualization;Work

PROJECT_TITLE: Mechanical properties of adipose tissue and its effect on breast cancer

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Chronic Kidney Disease (CKD) is a common, complex condition associated with many complications and high mortality that disproportionately affects African American and Hispanic communities. As part of the Multi-omics in Health and Disease consortium, we will establish a CKD Disease Study Site to evaluate if multi-omic approaches can improve precision medicine and promote equity in CKD care in ancestrally diverse populations.

PI_NAMEs: KIRYLUK, KRZYSZTOF  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African American;African American population;African ancestry;Anemia;APOL1 gene;Blood;Bone Diseases;burden of illness;Cardiovascular Diseases;Caring;Chronic;Chronic Kidney Failure;Classification;Clinical;clinical care;cohort;comorbidity;Complex;cost;Data;design;Diabetes Mellitus;Diagnosis;Disease;disorder control;disorder risk;disorder subtype;Disparity;Economic Factors;Economics;Education;Electrolytes;Ensure;Environment;Environmental Exposure;Environmental Monitoring;Epidemiology;epidemiology study;Epigenetic Process;Equity;Ethics;Etiology;Exclusion;experience;Exposure to;Filtration;Frequencies;Genetic;genetic predictors;genetic risk factor;Genetic study;genetic testing;Genomics;Glomerular Filtration Rate;Goals;Health;health equity promotion;Heritability;high risk;high throughput technology;Hispanic;hispanic community;Hispanic Populations;Histologic;Human Genetics;Immune;Immune System Diseases;improved;Individual;Injury;Injury to Kidney;innovation;Intervention Studies;kidney biopsy;Kidney Diseases;kidney dysfunction;Lead;Leadership;Life;Lupus;Malignant Neoplasms;Metabolic dysfunction;Metabolism;metabolomics;Methods;Minority;Minority Groups;Mission;Molecular;Molecular Disease;molecular marker;molecular subtypes;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Nephrology;nephrotoxicity;non-diabetic;novel;Outcome;outreach;Participant;Patients;Pattern;Phenotype;Play;pollutant;Population Heterogeneity;Positioning Attribute;precision medicine;Prevalence;prospective;Prospective cohort;Prospective Studies;Proteomics;Protocols documentation;Public Health;recruit;Renal function;Reproducibility of Results;Research;Research Design;Risk;risk variant;Role;Science;Site;social;social factors;social health determinants;Socioeconomic Factors;Standardization;statistics;stressor;support network;Systemic disease;Toxic Environmental Substances;Toxicant exposure;transcriptomics;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Urine;Work

PROJECT_TITLE: Multi-Omics for Chronic Kidney Disease


ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Center of Biomedical Research Excellence (COBRE) for Stress, Trauma, and Resilience (STAR) will serve as the only research center in Rhode Island focused on stress, trauma, and resilience. The STAR COBRE will catalyze the development of promising, early career faculty to emerge as leading, independently- funded investigators conducting transformative research in stress, trauma, and resilience. Capacity and infrastructure created by the STAR COBRE will establish The Miriam Hospital as a vibrant regional and national hub for faculty development, transformative research focused on: isolating and disentangling biological and behavioral mechanisms of risk and resilience following exposure to stress, trauma and adversity during sensitive periods of development, with ecologically-valid in vivo measurements leading to novel and actionable intervention targets to improve health.

PI_NAMEs: STROUD, LAURA R (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;Adult;adverse childhood events;Adverse event;Affective;American;Behavioral;Behavioral Mechanisms;Biological;Biological Markers;Cardiovascular Diseases;career;Centers of Research Excellence;Child;Child Abuse and Neglect;Child Sexual Abuse;Childhood;childhood adversity;Chronic Obstructive Pulmonary Disease;community advisory board;community partnership;Data;data management;deprivation;Development;Diet;Dimensions;Disease;Doctor of Philosophy;Documentation;early childhood;early life adversity;early-career faculty;Education;emotion regulation;Ethics;ethnic minority;Evaluation;executive function;experience;experimental study;Exposure to;Faculty;faculty mentor;Faculty Recruitment;food insecurity;Funding;Goals;Health;Hospitals;human subject;Hypertension;improved;in vivo;Inflammatory;Infrastructure;innovation;Intervention;Laboratories;Lead;Leadership;Life Cycle Stages;life span;Link;maltreatment;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Metabolic;Methods;Minority Groups;multidisciplinary;neglect;next generation;novel;Obesity;Outcome;pediatric trauma;perinatal outcomes;Phase;physical conditioning;Pilot Projects;poor health outcome;Population Heterogeneity;Poverty;Pregnancy;pregnancy disorder;programs;racial minority;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;resilience;resilience research;Resources;Rhode Island;Risk;Sampling;Science;Scientist;statistics;Strategic Planning;Stress;stress reactivity;stressor;substance use;Symptoms;Teacher Professional Development;Technology;Time;Training;Trauma;Trauma Research;Underrepresented Minority;United States National Institutes of Health;Vulnerable Populations;Weight Gain;young adult

PROJECT_TITLE: COBRE for Stress, Trauma and Resilience (STAR)


NIH_SPENDING_CATS: Nutrition

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  The importance of proper regulation of cell growth and energy homeostasis to human health is underscored by the association of many disease states with altered energy states, including diabetes, cancer, and neurological diseases. Therefore, it is the goal of this work to resolve the controversial role of mTORC1 inhibition caused by AMPK activation in regulating the gene expression, autophagy, and lipid synthesis involved in cellular metabolic reprogramming. Understanding the basic principles of how mTORC1 inhibition supports AMPK’s ability to reprogram metabolism and restore energy homeostasis provides conceptual advances for understanding these key mediators of cellular metabolism and offers mechanistic insight into how dysregulation of these pathways can lead to metabolic dysfunction and disease to allow us to identify new therapeutic strategies for treatment of metabolically-linked human disease.

PI_NAMEs: VAN NOSTRAND, JEANINE L (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 5'-AMP-activated protein kinase;Alanine;Autophagocytosis;Biochemical;cell growth;cell growth regulation;Cell Physiology;Cells;Complex;Diabetes Mellitus;Disease;energy balance;Energy consumption;Environment;experimental study;Failure;FRAP1 gene;functional genomics;Gene Expression;Genetic Transcription;Goals;Growth;Health;Homeostasis;Human;human disease;innovation;insight;Knowledge;Laboratories;Link;Lipids;Malignant Neoplasms;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Nervous System Disorder;novel;novel therapeutic intervention;Nutrient;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Process;programs;Protein Synthesis Inhibition;Regulation;Research;Role;Serine;Signal Pathway;Signal Transduction;Stress;Tissues;treatment strategy;Work

PROJECT_TITLE: The functional role of mTORC1 regulation by AMPK in cellular metabolic reprogramming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric

PROJECT_TERMS: Adolescent;Adult;Advisory Committees;Behavioral;Budgets;career development;Centers of Research Excellence;Child;childhood adversity;Collaborations;Communication;Communities;community advisory board;Data;Development Plans;Education;Educational workshop;Effectiveness;Ensure;Ethnic Population;Evaluation;experience;Exposure to;Faculty;Feedback;fetal;Fostering;Funding;Grant;Hospitals;human subject;improved;Individual;Infant;Infrastructure;innovation;Institution;International;Intervention;Lead;Leadership;meetings;member;Mentors;Mentorship;Methods;Minority Groups;Mission;Molecular;Neurobiology;next generation;novel;Outcome;Pilot Projects;programs;Psychiatrist;puberty transition;racial population;Recording of previous events;recruit;Regulation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;resilience;resilience research;Resources;Rhode Island;Risk;Risk Marker;Science;Series;Services;Social Work;State Government;Stress;stress management;success;symposium;Technology;Training Programs;Trauma;Trauma Research;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;visiting scholar;Vulnerable Populations;Writing

PROJECT_TITLE: Core A:  Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE  Diffuse-Large-B-cell-lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma and remains incurable in ~30% of patients. Coding-genome sequencing efforts identified several genes/pathways altered in this disease, including new potential therapeutic targets; however, the non-coding genome of DLBCL remains largely unexplored. This proposal builds on our recent discovery of a highly pervasive, pathogenetically relevant mutational mechanism targeting super-enhancers in DLBCL that is likely to significantly influence the current understanding of the somatic genetic landscape of this disease, by identifying novel mechanisms of dysregulation for known oncogenes, as well as new dysregulated genes and pathways, with implications for precision classification and therapeutic targeting of DLBCL.

PI_NAMEs: DALLA-FAVERA, RICCARDO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: B-Cell NonHodgkins Lymphoma;B-Lymphocytes;BCL2 gene;BCL6 gene;Binding;CAR T cell therapy;cell growth;Cells;Cellular biology;Classification;Clinical;Code;CRISPR correction;CRISPR/Cas technology;CXCR4 gene;Disease;Down-Regulation;Enhancers;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Glucocorticoid Receptor;Goals;Impairment;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphomagenesis;Mutate;Mutation;Nature;new therapeutic target;novel;NR3C1 gene;Oncogenes;Oncogenic;Pathogenesis;Pathway interactions;Patients;Phenotype;PRDM1 gene;prevent;programs;Proto-Oncogenes;Recurrence;Research;Role;Site;Steroid Receptors;Taxonomy;therapeutic target;Transcription Repressor;tumor heterogeneity;Untranslated RNA

PROJECT_TITLE: From pathogenesis to new therapeutic targets in diffuse large B cell lymphoma


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BOCK, BETH C (contact)

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Applications Grants;Behavior;Behavioral;Biological;career development;Centers of Research Excellence;Collection;complex data;Computer software;computerized data processing;Computers;Data;data cleaning;Data Collection;data harmonization;data integration;data management;Data Management Resources;data pipeline;data repository;data sharing;design;Development;Devices;digital phenotyping;Educational workshop;electronic data;Emerging Technologies;Ensure;Equipment;experience;Faculty;Faculty Recruitment;Fertilization;Fostering;Future;Goals;Health;Health Professional;Hospitals;human subject;Infrastructure;innovation;innovative technologies;Intervention;Intervention Studies;Knowledge;Laboratory Study;longitudinal analysis;Measurement;Measures;member;Metadata;Methodology;Methods;Modeling;new technology;novel;novel strategies;Observational Study;Outcome;Physiological;Pilot Projects;Policy Maker;Procedures;Public Health;Publications;Qualitative Methods;Quality Control;Records;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Research Training;resilience;Resources;response;Rhode Island;Scientific Advances and Accomplishments;Secure;Services;Statistical Data Interpretation;statistics;Stress;supportive environment;sustainable resource;technological innovation;Technology;technology validation;temporal measurement;Time;tool;Training;Trauma;visual tracking;Vulnerable Populations;Work;working group

PROJECT_TITLE: Core B:  Technology, Assessment, Data, and Analysis Core


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Spina bifida (SB), a breech in the spine through which nerve roots protrude, causes a spectrum of disabilities associated with permanent and irreversible neurological damage, and arises from a complex interaction of multiple changes or variants in the genes that converge to predispose to the condition. We will use advanced DNA sequencing, computation methods and biological validation of effects on gene function to analyze specific gene and gene combination mutations with the greatest influence on the disorder, and illuminate how these genes interact to cause SB. This will be essential research toward seeking new ways to prevent SB from occurring and to improve the lives of those affected by this birth defect.

PI_NAMEs: FINNELL, RICHARD H.;ROSS, MARGARET ELIZABETH (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Adhesions;Admixture;Affect;Apical;Binding Sites;Biological;Biological Process;Biological Testing;Brain;Breeding;Candidate Disease Gene;Caring;case control;Case/Control Studies;cell type;Cells;Cellular biology;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohesin;cohort;Collaborations;comparison control;Complex;Computational Biology;computerized tools;Computing Methodologies;Congenital Abnormality;constriction;Copy Number Polymorphism;Couples;CRISPR/Cas technology;Data;de novo mutation;disability;Disease;disorder risk;DNA sequencing;effective therapy;Embryo;Enhancers;Environmental Risk Factor;Equilibrium;Etiology;Evaluation;Event;Exons;Failure;Family;Family Study;Folic Acid;folic acid supplementation;Food Supply;Fortification;Frequencies;frontier;Gene Combinations;Gene Expression;gene function;gene interaction;Genes;Genetic;Genetic Epistasis;Genetic Predisposition to Disease;Genetic Risk;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome analysis;genome editing;Genomic approach;Genomic Segment;Genomics;Goals;Hand;Heterozygote;Histologic;Human;human embryonic stem cell;Human Genome;human model;human stem cells;Impairment;improved;In Vitro;in vitro Model;in vitro testing;in vivo;Individual;induced pluripotent stem cell;Inherited;innovation;insight;intrauterine environment;learning strategy;Machine Learning;Maps;MAX gene;Meningomyelocele;Methods;Modeling;Molecular;mouse model;multiple datasets;Mus;Mutagens;Mutation;Natural Immunity;Nerve;Nervous System Trauma;network models;Neural tube;Neural Tube Closure;Neural Tube Defects;novel;novel strategies;Organogenesis;Organoids;Parents;Pathogenesis;Pathway interactions;Patients;Pattern;Population;Population Control;precision medicine;Pregnancy;prevent;Prevention;Proliferating;Proteins;Publishing;rare variant;Research;Risk;Risk Assessment;Sampling;Sampling Biases;Selection Bias;self organization;Sequence Analysis;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;Spinal Dysraphism;stem cell proliferation;Structural defect;System;Systems Biology;Technology;Testing;three dimensional structure;TP53 gene;transcription factor;transcriptome;translation to humans;transmission process;Untranslated RNA;Validation;Variant;Vertebral column;whole genome

PROJECT_TITLE: Understanding Genetic Complexity in Spina Bifida

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Patient Safety;Pediatric;Social Determinants of Health

PI_NAMEs: PARADE, STEPHANIE HART (contact)

PROJECT_TERMS: Address;Adult;Behavioral;biobehavior;Biological;Centers of Research Excellence;Child;Childhood;childhood adversity;Clinical;clinically significant;Communities;community partners;community partnership;Competence;Data;Development;disadvantaged background;Discrimination;Disease;Documentation;Economic Factors;Educational workshop;Environment;equity, diversity, and inclusion;Ethics;ethnic minority;experience;Exposure to;Faculty;Goals;Health;Hospitals;human subject;human subject protection;Individual;Infrastructure;innovation;life span;Local Government;Maintenance;marginalization;marginalized population;Medical;Mental Health;neighborhood disadvantage;Outcome;physical conditioning;Population;Population Heterogeneity;Poverty;racial minority;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;resilience;Resources;Risk;Risk Factors;Services;Sexual and Gender Minorities;social stigma;Socioeconomic Status;State Government;Stress;structural determinants;success;Symptoms;Training;Trauma;Underserved Population;Vulnerable Populations;Work

PROJECT_TITLE: Core C: Community Collaborative Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LANCASTER

ORG_NAME: SIMULATIONS PLUS, INC.

PHR: Development and validation of a workflow to conduct virtual bioequivalence studies using PBBM-PBPK models. – Specific Aims The proposed project will utilize state-of-the-art physiologically based biopharmaceutics model (PBBM) and physiologically based pharmacokinetic (PBPK) modeling to develop and validate a workflow to conduct virtual bioequivalence studies. This project will support the FDA in its assessment of generic drug products. The first objective of this proposal will be to validate the ability of two PBBM-PBPK modeling platforms, GastroPlus© and PK-SIM©, to predict inter- and intrasubject variability. Then, the second objective of this proposal will be to develop and validate a workflow for designing and performing a reliable virtual bioequivalence study using PBBM-PBPK models, validated for their intended purpose, to detect formulation differences between the reference standard product and a prospective generic drug product that may impact the bioequivalence outcome.

PI_NAMEs: MARTINS, FREDERICO SEVERINO (contact)

PROGRAM_OFFICER_NAME: TSAKALOZOU, ELEFTHERI


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research;Youth Violence

PI_NAMEs: VERGARA-LOPEZ, CHRYSTAL  (contact)

PROJECT_TERMS: 17 year old;Adaptive Behaviors;adaptive intervention;Adolescence;Adolescent;Adult;Affective;Age;Aggressive behavior;Anger;Anxiety;anxious;attentional bias;career;Caregivers;Case Study;Centers of Research Excellence;Child;Child Abuse and Neglect;child protective service;childhood adversity;Chronic;Clinical;clinical diagnostics;Cognition;Cognitive;cognitive control;cognitive process;Data;Depressed mood;deprivation;design;Development;Diagnostic;Dimensions;early childhood;early life adversity;Ecological momentary assessment;emerging adult;emerging adulthood;emotion regulation;emotional abuse;emotional neglect;emotional stimulus;Emotions;Environment;Executive Dysfunction;executive function;experience;Exposure to;falls;flexibility;follow-up;forging;Funding;Health;health assessment;in vivo;informant;Infrastructure;Intervention;Interview;Laboratories;Lead;Learning;Life;Link;Longitudinal Studies;maltreatment;Measures;Mediating;Memory;Mental Depression;Mental disorders;Mental Health;Methods;middle childhood;Modeling;mood symptom;Moods;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;personalized medicine;Persons;Phase;physical abuse;physical neglect;prevent;Process;Protocols documentation;Psychological reinforcement;Psychopathology;Punishment;Recording of previous events;recruit;Recurrence;Regulation;Reporting;Research;Research Project Grants;resilience;resilience factor;Rewards;Risk;Risk Factors;Role;Sampling;Severities;Sexual abuse;Shapes;Stimulus;Stress;substance use;Symptoms;synergism;System;Technology;technology development;Testing;theories;Thinking;Time;Trauma;Visit;Visual;visual tracking;young adult

PROJECT_TITLE: Project 1:  Childhood Maltreatment, Repetitive Negative Thinking, and Mental Health in Adolescence: A 12-Year Longitudinal Study


ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Structural variants (SVs) have been difficult to detect with conventional DNA sequencing methods, however, they are associated with complex phenotypes. The proposed research will develop a new generation of computational tools that take advantage of cutting-edge DNA and RNA sequencing technologies to characterize and phase SVs from a large population of samples. This effort is expected to have a major impact in the understanding of complex diseases.

PI_NAMEs: ZHOU, XIN  (contact)

PROJECT_TERMS: Algorithms;Area;Base Pairing;Complex;computerized tools;Copy Number Polymorphism;Data;Data Set;design;Detection;Development;Diploidy;Disease;DNA sequencing;Etiology;Generations;Genetic;Genetic Predisposition to Disease;Genetic Variation;genome wide association study;genome-wide;Genomics;Haplotypes;Hereditary Disease;High-Throughput Nucleotide Sequencing;Human Genome;improved;Individual;insight;Link;Linkage Disequilibrium Mapping;Malignant Neoplasms;Maps;Methods;Patients;Pattern;Phase;Phenotype;Population;Population Control;Research;Risk;Sampling;single-cell RNA sequencing;Technology;Third Generation Sequencing;tool;transcriptome sequencing;Variant;whole genome

PROJECT_TITLE: Detecting structural variants in a large population of samples through high-throughput sequencing data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE There is strong evidence to support a syndemic of depression, anxiety disorder, alcohol use disorder, hypertension, and HIV. In the proposed study, we will use a syndemic approach to adapt Medly Uganda- a mobile health platform developed and tested by our team- to address this syndemic using evidence-based strategies. We will use a human-centered design approach to develop Syndemic-Adapted Medly Uganda (SAMU), will conduct a clinical trial to assess its effectiveness at improving key mental health care cascade outcomes among patients living with HIV and hypertension in Uganda, and use mixed methods to evaluate engagement with SAMU.

PI_NAMEs: NAKASUJJA, NOELINE ;SCHWARTZ, JEREMY IAN (contact);SSINABULYA, ISAAC

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Africa South of the Sahara;alcohol use disorder;Algorithms;Anxiety;Anxiety Disorders;arm;Attention;Biological;Biosocial;Blood Pressure;Cardiovascular Diseases;Caregivers;Caring;Cellular Phone;Chronic;Clinic;Clinical;Clinical Trials;Collaborations;comorbidity;Complex;dashboard;Data;Detection;Diagnosis;digital platform;Disease;Dose;Economics;Effectiveness;effectiveness evaluation;Enrollment;Environment;Epidemic;Event;evidence base;Evidence based intervention;Face;Funding;General Population;Goals;Government;Government Officials;Health Personnel;Health Priorities;Health Services Accessibility;healthcare burden;Heart failure;HIV;human centered design;Hybrids;Hypertension;implementation measures;implementation science;implementation strategy;implementation study;implementation trial;improved;Individual;Infrastructure;innovation;instrument;Intervention;Interview;Life;Link;low and middle-income countries;Measures;medication compliance;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;mHealth;mhealth interventions;Mobile Health Application;multidisciplinary;National Institute of Mental Health;novel;Outcome;Participant;patient engagement;Patients;Penetration;Persons;Phase;pilot trial;Poverty;Prevalence;primary outcome;Privatization;Process;programs;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduce symptoms;Research;screening;secondary outcome;Self Care;service delivery;Severities;Shock;Site;social factors;Social Interaction;social stigma;standard of care;Stigmatization;syndemic;tailored messaging;Telephone;Testing;Text;Uganda;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: An mHealth implementation strategy to address the syndemic of mental illness, hypertension, and HIV in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHI-H(56)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Childhood Obesity;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: EVANS, E. WHITNEY  (contact)

PROJECT_TERMS: Address;Adherence;adipokines;adiponectin;Adipose tissue;Adult;adverse childhood events;Affect;Age;age group;American;Anemia;Animal Model;Anxiety;anxiety symptoms;Asthma;Behavior;Biological;Biological Markers;blood glucose regulation;Blood specimen;Body mass index;C-reactive protein;Calories;career;caregiver stress;Caregivers;Centers of Research Excellence;Child;Child Health;Childhood;childhood adversity;Chronic Disease;Collection;Communities;cytokine;depressive symptoms;Diet;dietary;Disadvantaged;disorder risk;Eligibility Determination;Energy consumption;excessive weight gain;experience;Exposure to;Fasting;Fatty acid glycerol esters;Food;food insecurity;Food Services;Foundations;Glucose;glucose metabolism;Glycosylated hemoglobin A;Health;health disparity;Healthy Eating;Hour;Household;Hydrocortisone;Impairment;Impulsivity;indexing;Inflammation;Inflammatory;Insulin;Insulin Resistance;Interleukin-6;Intervention;Leptin;Lipids;Low income;Malnutrition;maternal depression;Measures;Mediating;Mental Depression;Mental Health;Metabolic syndrome;Minority;Moods;Nature;Newsletter;novel;Nutrient;nutrition;Obesity;obesity in children;Outcome;Overweight;Participant;physical conditioning;Poverty;prevent;Prevention;Price;primary endpoint;Problem behavior;programs;prospective;Prospective Studies;Proteins;Qualifying;Randomized;recruit;Research;resilience;Resources;Rhode Island;Risk;Role;Schools;Secure;service programs;social health determinants;Stress;stress symptom;sugar;Testing;Time;Training;Trauma;Unhealthy Diet;United States;United States Department of Agriculture;Weight Gain;Woman;Work;Youth

PROJECT_TITLE: Project 3:  Isolating food insecurity to understand childhood health outcomes and biological mechanisms of risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Anal cancer is particularly high among certain groups; health disparity further contributes to this high risk among minorities. The proposed research will examine performance of emerging screening methods for aHSIL (precancerous condition of anal cancer) among minorities with a high risk of anal cancer, as well as characterize DNA methylation, immunologic response, and social determinants associated with aHSIL, most likely to progress to cancer. Findings will provide much-needed evidence for anal cancer screening strategies to reduce health disparities, improve screening outcomes, and decrease the incidence of anal cancer among high-risk minorities.

PI_NAMEs: FLOWERS, LISA C. (contact);ROSA-CUNHA, ISABELLA ;XIAO, CANHUA

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: advanced disease;African Caribbean;Anus;ASCL1 gene;Biological Markers;biomarker identification;Biopsy;black men;Black Populations;burden of illness;cancer invasiveness;cancer risk;carcinogenesis;Caribbean region;Caring;Cells;Central America;Cervical;chronic infection;Clinical;Consumption;cost;Cytology;Data;design;Development;Diagnosis;Discrimination;Disease;Disparity;disparity reduction;DNA Methylation;Dysplasia;Early Diagnosis;Environment;Epigenetic Process;ethnic diversity;evidence base;Expert Opinion;food insecurity;Goals;Guidelines;Health;health disparity;high risk;high risk population;High Risk Woman;HIV;housing instability;HPV-High Risk;Human papilloma virus infection;Immune;Immune response;Immune Targeting;immunological intervention;Immunologics;immunoregulation;Immunotherapeutic agent;improved;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;Latino Population;Latinx;Lesion;Literature;Longitudinal Studies;Malignant - descriptor;Malignant neoplasm of anus;Malignant Neoplasms;Measures;men who have sex with men;men who have sex with men and women;Methods;Methylation;methylation biomarker;Minority;Minority Groups;Minority Men;Minority Women;mortality;Neighborhoods;Oncogenic;Outcome;overtreatment;Patient Triage;Patients;Performance;Persons;Play;Population Heterogeneity;Poverty;Precancerous Conditions;Prevalence;racial disparity;Recommendation;recruit;Reduce health disparities;Research;Resolution;Risk;Risk Factors;risk stratification;Role;Sample Size;Sampling;screening;Screening for cancer;screening guidelines;Sensitivity and Specificity;side effect;Site;social determinants;social health determinants;South America;Squamous intraepithelial lesion;Stimulus;Time;Translating;tumor progression;tumor-immune system interactions;Universities;Viral;Vulva;Woman

PROJECT_TITLE: Screening strategies and social determinants of health among people with high risk of anal cancer

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative The proposed research is relevant to public health because it proposes a novel digital health solution to address the major challenges of crowding, delays in care, and disparities in emergency care in the United States. The proposed solution will use advanced predictive analytics and patient electronic health record data to prioritize patient needs and acuity more optimally at the time of patient arrival to the emergency department. The proposed research is relevant to AHRQ’s mission of producing evidence to make healthcare safer, higher quality, and more equitable.

PI_NAMEs: SAX, DANA  (contact)

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Improving safety and quality of emergency care using machine learning-based clinical decision support at triage

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: AYALA, NINA KARLSEN (contact)

PROJECT_TERMS: acceptability and feasibility;Anxiety;Birth;Caring;Centers of Research Excellence;diagnostic strategy;digital;Economic Burden;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;Equity;experience;Health;Health Benefit;health equity;improved;Individual;innovation;Maternal Health;Medical;Mental Depression;Mental Health;mindfulness;mindfulness intervention;Minority Groups;Needles;optimism;Outcome;Participant;Perinatal;perinatal health;Persons;Population;Post-Traumatic Stress Disorders;Postpartum Period;Pregnancy;pregnant;Prevention;Psychopathology;Randomized;randomized, clinical trials;Reduce health disparities;resilience;resilience factor;Risk;Role;routine care;social;Stress;Telephone;Trauma;trial comparing;Underserved Population

PROJECT_TITLE: Mindfulness, Optimism and Resilience for Perinatal Health and Equity (MORPHE) Trial


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JENNINGS MATHIS, KAREN  (contact)

PROJECT_TERMS: acceptability and feasibility;Adolescent;aged;Black race;Centers of Research Excellence;Data;Diagnosis;Disadvantaged;Discrimination;Eating;Eating Behavior;Ecological momentary assessment;Emotional;emotional functioning;experience;Focus Groups;Health;health care disparity;health determinants;insight;intersectionality;Intervention;Link;Lived experience;marginalized population;Mental disorders;Mental Health;Mental Health Services;negative affect;perceived discrimination;Physical Function;Protocols documentation;psychologic;racial discrimination;recruit;resilience;Risk;Risk Behaviors;Screening procedure;social;Stress;stressor;substance use;Surveys;Testing;Theoretical model;Trauma;Youth

PROJECT_TITLE: Perceived Discrimination, Intersection of Identities, and Health Risk Behaviors in Black Adolescents


ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Despite ample evidence supporting physician diversification as a mechanism for reducing health disparities, diversity remains elusive at all levels in surgery. The inability to recruit and/or retain a diverse surgeon workforce is a direct result of lack of inclusion in the surgical training environment. The proposed research seeks to understand and leverage organizational culture to improve inclusion in surgical residency programs; with input from experts and key stakeholders, we will develop and contextually adapt interventions that target organizational policies and practices (rather than individual beliefs or skills) to enhance inclusion.

PI_NAMEs: HU, YUE-YUNG  (contact)

PROGRAM_OFFICER_NAME: WYATT, DERRICK

PROJECT_TITLE: Improving Inclusion in Surgical Residency to Advance Workforce Diversity and Health Equity

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: CHARLESTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE Retained Foreign Objects (RFOs) are one of the most well recognized and persistent patient safety problems, with an estimated 3000-50,000 RFOs per year, and an 80% morbidity rate. The Retained Foreign Object Reduction and Mitigation (ReFORM) patient safety learning laboratory will explore the causes of and solutions to RFOs using a systems engineering approach, which will initiate the most fundamental reappraisal of the causes of and solutions to RFOs for more than 20 years.

PI_NAMEs: CATCHPOLE, KEN  (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Functional precision oncology has the potential to revolutionize treatment options for cancer patients by providing much needed new approaches to identify the correct therapy for individual patients. Most patients with melanoma, a deadly skin cancer, are treated with one of two very different therapeutic options – either of which cure many patients, but neither of which work on all patients, making melanoma an ideal model system in which to develop and demonstrate functional approaches. We propose to engineer a prototype technology that analyzes small biopsies of living tumors to predict which melanoma patients will respond to which therapy, to help address the burden of melanoma and to provide a novel, functional approach that can be extended to other cancers in the future.

PI_NAMEs: JUDSON-TORRES, ROBERT LAIRD;ZANGLE, THOMAS ANDREW (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adoption;analytical method;Animal Model;Animals;Area;Behavior;Benchmarking;Biocompatible Materials;Biological Models;Biopsy;Cancer Intervention;Cancer Patient;cancer risk;cancer type;Caring;Cell Line;Cells;cellular imaging;Cessation of life;Characteristics;checkpoint inhibition;checkpoint therapy;Classification;Clinical;clinical care;clinical decision-making;clinical translation;Clinical Trials;clinically actionable;Clonal Expansion;Coupled;Darkness;Data;Data Analyses;Decision Making;density;Development;Disease Resistance;Distal;Drug resistance;Engineering;Epigenetic Process;Exposure to;Flow Cytometry;Fluorescence;Fluorescent Antibody Technique;Future;genetic signature;Goals;Heterogeneity;Human;Image;Immunotherapy;improved;in vivo;Individual;individual patient;Intervention;Kinetics;Label;light scattering;Longterm Follow-up;machine learning classifier;Malignant Neoplasms;Measurement;Measures;Melanoma;Melanoma Cell;Melanoma patient;Melanosomes;Methods;Microscopy;Modification;Molecular Profiling;Monitor;Morphology;Multimodal Imaging;multimodality;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel strategies;Organelles;patient derived xenograft model;Patient-Focused Outcomes;Patients;Performance;personalized approach;Phase;Phenotype;Population;Population Heterogeneity;pre-clinical;Pre-Clinical Model;precision medicine;precision oncology;predictive test;prevent;Primary Neoplasm;programs;prospective;prototype;Punch Biopsy;quantitative imaging;Receiver Operating Characteristics;Reporter;research clinical testing;Resistance;Resolution;response;Sampling;Selection for Treatments;Series;Skin Cancer;Specimen;Speed;standard of care;stem;stem-like cell;success;Surface;survival prediction;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic candidate;therapy resistant;transcriptomics;Translating;Translations;tumor;tumor progression;Validation;Visualization;Work

PROJECT_TITLE: Development and Pre-Clinical Validation of Quantitative Imaging of Cell State Kinetics (QuICK) for Functional Precision Oncology

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research;Social Determinants of Health;Sudden Infant Death Syndrome;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Substantial racial and socioeconomic disparities persist in Sudden and Unexpected Infant Deaths (SUID); SUIDs are preventable with greater adherence to safe infant sleep guidelines. Our team's safe sleep video education program, called TodaysBabyTM, delivered through text messages in the first 2 months after birth to 1600 mothers across the US, was effective at eliminating racial and economic disparities in maternal adherence to safe sleep education (1R01HD072815). We therefore propose a cluster randomized trial to test implementation and effectiveness of "high touch" and "low touch" strategies to sign up mothers into the TodaysBabyTM program at 20 US hospitals in counties with high rates of SUID; this study will inform wide-scale dissemination of TodaysBabyTM, and subsequent adherence to safe sleep practices and reduction of SUID in communities with historically high SUID rates.

PI_NAMEs: COLSON, EVE R;MOON, RACHEL Y (contact);PARKER, MARGARET GRAHAM KEMPER

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Academy;Accidental Injury;Address;Adherence;Alaska Native;American;American Indians;Attention;Back to Sleep;Beds;Birth;Black race;Cessation of life;Cluster randomized trial;Code;Communities;cost;County;Crossover Design;Data;Death Rate;Decision Making;Disparity;Dissemination and Implementation;economic disparity;Education;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation study;effectiveness/implementation trial;Electronic Mail;Eligibility Determination;Environment;Equity;Ethnic Origin;Ethnic Population;Future;Guidelines;Health;health organization;Healthcare Systems;Hospitalization;Hospitals;Hybrids;implementation outcomes;implementation research;implementation strategy;implementation/effectiveness;Income;Infant;Infant Care;Infant Mortality;Informed Consent;Infrastructure;Insurance;Intervention;Location;Low Income Population;Medicaid;member;Modeling;Mothers;National Institute of Child Health and Human Development;Pacifier Use;Parents;Pediatrics;Penetration;Policies;postneonatal mortality;Postpartum Period;preventable death;Proctor framework;program costs;programs;Public Health;Race;racial disparity;racial population;Randomized;Randomized, Controlled Trials;recruit;Research Personnel;Resources;Risk Reduction;Sleep;sleep position;Social Marketing;social media;socioeconomic disparity;socioeconomics;Strategic Planning;study population;success;Sudden infant death syndrome;supine sleep;Techniques;Testing;Text Messaging;Time;Touch sensation;Training;Translating;video delivery;Work

PROJECT_TITLE: Get Social Media and Risk-Reduction Training (GET SMART)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The microbiome is related to a vast range of disorders and conditions, yet our limited understanding of how microbes interact with each other, with host genomics, and with disease outcomes poses a serious barrier to translation. Within the context of three of the largest and richest microbiome profiling studies, this proposal seeks to develop statistical and computational approaches to enhance the mapping of these critical relations. The knowledge gained from our methods offers the potential to improve etiology and also drive the development of new therapies, particularly as the microbiome is modifiable.

PI_NAMEs: WU, MICHAEL CHIAO-AN (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Area;Automobile Driving;Back;burden of illness;cancer immunotherapy;Cardiovascular Diseases;Clinical;cohort;Computer software;computerized tools;Data;Detection;Development;Diabetes Mellitus;dimension reduction;Disease;Disease Outcome;Ensure;Etiology;Failure;flexibility;Genetic;genetic variant;Genomics;gut microbiome;Heterogeneity;Human;Human Microbiome;improved;Individual;Infection;instrument;Intervention;Joints;Knowledge;Link;Literature;Lung;Malignant Neoplasms;Maps;Mendelian randomization;Methodology;Methods;Microbe;microbial;microbiome;Modeling;Neurodegenerative Disorders;novel;novel therapeutics;open source;Outcome;Patients;Pregnancy;preventive intervention;Process;Quantitative Trait Loci;rare variant;Research Personnel;risk mitigation;Risk Reduction;Role;Sample Size;Scientific Advances and Accomplishments;Statistical Methods;success;Taxon;Taxonomy;Testing;Therapeutic Intervention;tool;translational barrier;user friendly software;vaginal microbiome;Work

PROJECT_TITLE: Statistical Methods for Enhanced Mapping of Microbiome Relationships

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]