ACTIVITY: ZID

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

PI_NAMEs: LEGGIO, LORENZO  (contact)

PROJECT_TERMS: Academia;Acute;addiction;Advanced Development;Advertisements;Agreement;Area;Baltimore;base;Basic Science;Behavioral;brain dysfunction;Care given by nurses;Caring;Certification;Chronic;Clinical;clinical care;Clinical Investigator;Clinical Research;clinical training;Clinical Trials Data Monitoring Committees;cognitive process;Collaborations;Communities;community engagement;Community Outreach;Contracts;Data Collection;data management;Dependence;Development;Education;Educational Materials;equity, diversity, and inclusion;Ethics;Experimental Psychology;Fortification;Fostering;Functional Imaging;Future Generations;Goals;Harm Reduction;Head;Health;health communication;health inequalities;Human;Human Resources;improved;Individual Differences;Infrastructure;innovation;Inpatients;Intervention;Intramural Research Program;Investigation;Joints;Laboratories;Leadership;Magnetic Resonance Imaging;Marketing;Maryland;Medical center;Medicine;member;Mentors;Methodology;Mobile Health Application;Molecular Genetics;Naloxone Training;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;neuroimaging;neuroregulation;Neurosciences;novel;Nurses;opioid overdose;Outpatients;outreach;Overdose reduction;Participant;Patient Care;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Physician Assistants;Policies;Population Study;pre-clinical;Private Sector;Procedures;Professional counselor;programs;protocol development;racial disparity;recruit;Regulatory Affairs;Relapse;Remunerations;Research;Research Personnel;Research Support;Resources;Role;Safety;Science;Scientist;screening;Services;Smoking;Specialist;Spectrum Analysis;Statistical Data Interpretation;structural imaging;Substance Use Disorder;Techniques;Telephone;tenure track;Time;Tissues;Training;Training and Education;Training Programs;Transcranial magnetic stimulation;Translational Research;Transportation;United States National Institutes of Health;Universities;Vendor;virtual reality;Vision

PROJECT_TITLE: Office of the Clinical Director


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Patient Safety;Social Determinants of Health;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Adherence;Adult;Advertising;aging brain;alcohol use disorder;Area;Baltimore;Biometry;Black race;Characteristics;Clinical;clinical care;Clinical Investigator;Clinical Research;Clinical Trials Data Monitoring Committees;co-infection;Cognitive;college;Communities;Community Outreach;comorbidity;Compensation;Consult;Contracts;Counseling;Cross-Sectional Studies;Data;Data Analyses;data management;Data Scientist;Decision Making;Dedications;deep learning;design;Development;digital phenotyping;Disease;Drug Addiction;Drug usage;Education;Emergency Care;emotion regulation;Environment;Esthesia;executive function;Head;Health Benefit;health disparity;Hepatitis C virus;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seropositivity;Home;Human;Human immunodeficiency virus test;human subject protection;Impaired cognition;improved;Impulsivity;Incidence;Individual;Infrastructure;inpatient service;Institutional Review Boards;Intramural Research Program;intravenous drug use;Laboratories;Learning;Left;Link;Liver diseases;Magnetic Resonance Imaging;male;Maryland;Medical;medication compliance;Medicine;meetings;men who have sex with men;metropolitan;Monitor;National Institute of Drug Abuse;Neighborhoods;neuroimaging;neuropsychopharmacology;Newly Diagnosed;novel;Outcome;outreach;Paper;Participant;participant safety;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacy facility;pre-exposure prophylaxis;Prefrontal Cortex;Preparation;Printing;programs;Psychoneuroendocrinology;Publications;Radiology Specialty;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Retirement;Risk;Risk Behaviors;Role;Safety;Sampling;screening;secondary analysis;Self-control as a personality trait;Services;Sexual and Gender Minorities;Spectrum Analysis;substance use;Substance Use Disorder;System;Technology;tenure track;Testing;Transcranial magnetic stimulation;Translational Research;transmission process;treatment research;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: NIDA IRP Clinical Core support of the NIDA IRP HIV Clinical Program


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PI_NAMEs: HALL, JANET  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Agreement;Area;Asthma;Autoimmunity;Callback;Cardiovascular Diseases;Centrifugation;Client satisfaction;Clinical;Clinical Protocols;Clinical Research;clinical research site;clinical training;Clinical Trials Database;cohort;Collaborations;Core Facility;COVID-19;COVID-19 pandemic effects;Development;DNA;DNA Damage;Drug Kinetics;drug testing;Education;Educational workshop;electronic health record system;Electronics;Endocrine;Endothelium;Enrollment;Environmental Exposure;Ethics;Follow-Up Studies;Generations;Genetic Polymorphism;Goals;Guidelines;Human;human coronavirus;Human Rights;Human Subject Research;Immunology;improved;Individual;Inflammation;injury and repair;Institution;Institutional Review Boards;Investigation;Lung Diseases;Malignant Neoplasms;Metabolic Diseases;Mission;Monitor;National Institute of Environmental Health Sciences;Neuroendocrinology;North Carolina;novel coronavirus;Nursing Research;operation;Participant;Patient Recruitments;Patients;Phenotype;Procedures;programs;protocol development;Protocols documentation;quality assurance;receptor;Registries;Regulation;Research;Research Design;Research Personnel;Research Project Grants;Sampling;SARS coronavirus;Scientist;Series;Services;Severe Acute Respiratory Syndrome;Specimen;Structure;Susceptibility Gene;symposium;System;tenure track;Testing;Training;Training and Education;Training Programs;Translational Research;translational scientist;translational study;United States National Institutes of Health;Universities;web site;welfare

PROJECT_TITLE: Program in Clinical Research, Clinical Support Services and Clinical Training


ACTIVITY: ZIG

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Prevention;Substance Misuse

PI_NAMEs: WILSON, QUENTIN  (contact)

PROJECT_TERMS: Accreditation;Adherence;Administrator;Analgesics;Anesthetics;animal care;Animal Care and Use Committees;Animal Experimentation;animal facility;Animal Feed;Animal Husbandry;Animal Technicians;Animal Welfare;Animals;Area;Breeding;care systems;Caring;clinical diagnostics;Communicable Diseases;Consult;Contractor;Contracts;disorder prevention;Early Diagnosis;Ensure;Equipment;Euthanasia;federal policy;Goals;Health;Housekeeping;Human Resources;Intramural Research Program;Laboratory Animals;Maintenance;Medical;member;Mission;Monitor;Morbidity - disease rate;Mus;National Institute of Drug Abuse;Parasites;Physical Examination;Policies;Policy Compliance;Production;programs;Protocols documentation;Quarantine;Rat Transgene;Rattus;Regulation;Reporting;Research;Research Support;Rodent;Schedule;Scientist;Services;Source;Techniques;Training;Transgenic Organisms;Veterinarians;Water

PROJECT_TITLE: Animal Care


NIH_SPENDING_CATS: Complementary and Integrative Health;Endocrine Disruptors;Estrogen;Infectious Diseases;Natural Products;Nutrition

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: KURTZ, DAVID  (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adverse effects;Affect;American;Animal Experimentation;Animal Feed;Animals;Annual Reports;Beds;Biological;Chemicals;Clinical;Collaborations;comparative;Coronavirus;Crowns;daidzein;Diet;Disease;Dryness;Ecosystem;Endocrine Disruptors;Environmental Exposure;Escherichia coli;Exposure to;Fatty acid glycerol esters;Female;Genistein;Goals;Health;health science research;irradiation;Laboratories;Laboratory Animal Science;Laboratory Study;Manuscripts;Mass Spectrum Analysis;Medicine;meetings;metabolomics;Methods;microorganism;Monitor;mouse genome;Multimedia;multiplex detection;Mus;Mycotoxins;National Institute of Environmental Health Sciences;Operon;Outcome Study;Oxidoreductase;pan-genome;pathogen;Pathogen detection;Physiological;Phytoestrogens;Poly-fluoroalkyl substances;programs;Publishing;quality assurance;reproductive development;Research;research study;response;Rodent;Shigella;Soil;Source;Sterilization;Students;summer internship;Support Groups;Testing;Toxic effect;United States Environmental Protection Agency;United States National Institutes of Health;Universities;Water;welfare;Zearalenone

PROJECT_TITLE: Physiological Effects of Natural or Contaminating Compounds in a Rodent's Microenvironment


PI_NAMEs: COBLE, DONDRAE  (contact)

PROJECT_TERMS: Accreditation;animal care;Animal Care and Use Committees;Animal Experimentation;animal imaging;Animals;Beds;behavioral phenotyping;Clinical;comparative;Consultations;Cryopreservation;Derivation procedure;disease diagnosis;Embryo Transfer;Ensure;Equipment and supply inventories;Food;Guidelines;Health;International;Intramural Research;Intramural Research Program;investigator training;Medicine;National Institute of Environmental Health Sciences;National Toxicology Program;Operative Surgical Procedures;Policies;programs;quality assurance;Research Personnel;Research Project Grants;Research Support;Rodent;Scientist;Services;United States Public Health Service;Water

PROJECT_TITLE: Animal Research Support


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Pain Research

PI_NAMEs: WEBB, DONNA  (contact)

PROJECT_TERMS: Analgesics;Anesthesia and Analgesia;Anesthetics;Animal Behavior;animal care;animal colony;Animal Experimentation;Animal Model;Animal Welfare;Animals;Behavior assessment;Behavioral Assay;Blood specimen;Bupivacaine;Buprenorphine;Collaborations;comparative;Distress;Dose;Goals;Health;Home;Image;imaging study;improved;Injectable;Intramural Research Program;Investigation;Laboratories;Manuals;Medicine;Metabolic;Methods;Modeling;mouse model;Mus;National Institute of Environmental Health Sciences;Operative Surgical Procedures;Pain;Pain management;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Physiological;Procedures;Rattus;Research;Research Personnel;Rodent;Rodent Model;skills;Splenectomy;Surgeon;Surgical Models;System;Techniques;Therapeutic;Tissues;Training;Triage;Veterinary Medicine;welfare;Work

PROJECT_TITLE: Animal Refinement for Laboratory Rodents


ACTIVITY: ZIH

NIH_SPENDING_CATS: Bioengineering;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Substance Misuse

PI_NAMEs: LIN, JIA LING  (contact)

PROJECT_TERMS: addiction;Area;Automatic Data Processing;Baltimore;Basic Science;Behavioral;Biological;biomedical informatics;Chemicals;Clinical;Clinical Decision Support Systems;Clinical Research;Collaborations;Computational Science;computer program;Computer Systems;computerized tools;cyber security;Data;data interoperability;data mining;Data Science;Databases;design;Ensure;Exposure to;Extramural Activities;Fostering;Goals;Guidelines;health data;Illicit Drugs;Informatics;Information Management;Information Systems;Information Technology;Infrastructure;Knowledge Discovery;Knowledge Management;Laboratories;Laws;Location;Medical;Medical Research;Methods;mHealth;National Institute of Drug Abuse;new technology;novel strategies;Nurses;Patient Recruitments;Pharmacy facility;Physicians;Policies;pre-clinical research;Procedures;programs;Psychosocial Stress;Recommendation;Regulation;Research;Research Personnel;Resources;Science;scientific computing;Secure;Services;Site;Specific qualifier value;support network;System;Systems Analysis;Techniques;telework;Time;Training;Work

PROJECT_TITLE: Scientific Computing & Informatics Core (SCIC)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PROJECT_TERMS: Adherence;aging brain;alcohol use disorder;Area;Automatic Data Processing;Basic Science;Behavioral;Big Data;Biological;biomedical informatics;Brain;Clinical;Clinical Research;Cognitive;Collaborations;Collection;comorbidity;Computational Science;computer program;computer science;Computer Systems;computerized tools;Consultations;Counseling;cyber security;Data;Data Collection;data communication;data management;data platform;Data Science;Data Set;design;digital phenotyping;Electronics;Ensure;Extramural Activities;Fostering;gender minority;Goals;Guidelines;Health Benefit;health data;Health protection;HIV;HIV Infections;HIV risk;HIV-associated neurocognitive disorder;Human immunodeficiency virus test;Image;Impaired cognition;improved;Incidence;Informatics;Information Management;Information Systems;Information Technology;Knowledge Management;Laws;Left;Maintenance;marijuana use;Medical Records;Medical Research;Methodology;Methods;Mission;Modeling;National Institute of Drug Abuse;neuroinflammation;neurotoxicity;new technology;novel;Outcome;Personally Identifiable Information;Persons;Pharmaceutical Preparations;Policies;pre-clinical;pre-clinical research;Prefrontal Cortex;Process;programs;Rat Transgene;Rattus;Recommendation;Regulation;Research;Research Personnel;Research Project Grants;Resources;Retrieval;Risk Behaviors;Rodent Model;scientific computing;Secure;Services;sexual minority men;Specific qualifier value;Substance Use Disorder;support network;System;Systems Analysis;Techniques;Time;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Scientific Computing & Informatics Core (SCIC) project support of high-priority HIV projects


ACTIVITY: ZII

ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

PI_NAMEs: HANSON, CHRISTOPHER  (contact)

PROJECT_TERMS: Bacteriology;Basic Science;biodefense;built environment;Certification;Clinical;Clinical Research;Communicable Diseases;COVID-19;Emerging Communicable Diseases;Goals;HIV/AIDS;Infectious Disease Immunology;Infectious Diseases Research;Infrastructure;Intramural Research;Laboratories;Maintenance;Mission;National Institute of Allergy and Infectious Disease;Principal Investigator;programs;Research;research facility;Research Priority;tenure track;tool;Translational Research;United States National Institutes of Health;virology;Vision

PROJECT_TITLE: Activation, Maintenance and Certification of Infectious Diseases Labs


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: TRENT, JEFFREY M. (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TITLE: Genome Characterization Unit


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PI_NAMEs: EVANS, JAY  (contact)

PROJECT_TERMS: Adjuvant;Antigens;Development;efficacy testing;Lead;Messenger RNA;Modeling;Mus;prevent;programs;Recombinant Proteins;Recombinants;Specific qualifier value;Tuberculosis;Tuberculosis Vaccines;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: Development of an Optimized Adjuvanted TB Vaccine


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Although lung cancer is the leading cause of cancer-related death in the United States, over 540,000 Americans survive with treatment, making it the fourth leading diagnosis among cancer survivors, a 20% increase in 2022. Lung cancer surveillance plays an important role in survivorship care through the detection of both recurrent disease and new, `second primary' lung cancer, monitoring of toxicity associated with adjuvant treatment, reinforcement of smoking cessation, and management of fear and anxiety over potential recurrence; yet only 26% of patients receive the guideline-recommended imaging and 39% are lost to all follow-up after lung cancer resection. This proposal seeks to leverage RETURNS, a telehealth lung cancer surveillance program, to develop and test a remote lung cancer surveillance approach, combining Patient Reported Outcome (PRO) and community chest computed tomography (CT) assessment, in a learning health system to improve adherence to recommended surveillance guidelines by reducing barriers and making care more efficient and effective for patients, providers, and the healthcare system.

PI_NAMEs: ODELL, DAVID D. (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Development and Implementation of the REmote Telehealth User-Reported caNcer Surveillance (RETURNS) Program for Lung Cancer

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DANA POINT

ORG_STATE: CA

PI_NAMEs: CARO, ELIAS  (contact)

PROJECT_TERMS: Address;Biomedical Technology;Businesses;Clinic;commercialization;Contracts;design;Development;Development Plans;Educational Curriculum;experience;Fostering;Funding;Grant;innovation;interest;Learning;learning strategy;Marketing;Medical Device;Mentors;Outcome Assessment;Process;programs;recruit;Research;Research Personnel;Services;Small Business Innovation Research Grant;Small Business Technology Transfer Research;tool;Training;Training Programs;Translations;United States National Institutes of Health

PROJECT_TITLE: CONCEPT TO CLINIC: COMMERCIALIZING INNOVATION (C3I) PROGRAM TRAINING


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Idiopathic Pulmonary Fibrosis (IPF) inflicts a significant healthcare burden and high rate of mortality in the U.S. As a rare polygenic disorder, however, IPF poses challenges to existing disease gene-mapping strategies due to the extensive locus heterogeneity and difficulty of assembling massive sample sizes typical of common polygenic disorders. This project aims to develop more effective gene-mapping methods for rare polygenic disorders such as IPF. Our approach combines network-based approaches with analysis of pleiotropy with gene expression, polygenic risk score and heterogeneity of comorbidity to map novel IPF genes using whole- exome-sequencing and genome-wide association data.

PI_NAMEs: CHUN, SUNG  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Accounting;Address;biobank;Biogenesis;Biological;Candidate Disease Gene;cell type;Cells;Chromosome Mapping;Clinic;cohort;comorbidity;Computing Methodologies;Data;Data Set;Death Rate;Development;Disease;disease heterogeneity;Disease Outcome;drug development;exome;exome sequencing;Gene Cluster;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;Genetic Heterogeneity;Genetic Risk;Genetic study;genome wide association study;Genotype;Goals;healthcare burden;Heterogeneity;high risk;Human Genetics;human old age (65+);idiopathic pulmonary fibrosis;Individual;Libraries;loss of function;Lysosomes;Maps;Medical;Mendelian disorder;Methods;Modeling;Mutation;network models;Network-based;novel;novel therapeutics;Participant;Pathway interactions;Patients;Pattern;Penetrance;phenomics;pleiotropism;polygenic risk score;Population;Positioning Attribute;Prevalence;Process;pulmonary function decline;Pulmonary Surfactants;Quantitative Trait Loci;Rare Diseases;rare variant;Rest;reverse genetics;Rheumatoid Arthritis;risk prediction;Sample Size;Sampling;Scientist;severe COVID-19;Signal Transduction;Statistical Models;Structure;System;Techniques;Telomere Maintenance;Testing;Time;Tissues;trait;Trans-Omics for Precision Medicine;Validation;Variant

PROJECT_TITLE: Computational Methods for Systems Genetic Analysis of Rare Polygenic Disorder

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Electronic Nicotine Delivery Systems;Hematology;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Collectively, the experiments presented in this application, some of which are translational in nature, address fundamental, epigenetic and mechanistic concerns regarding the cardiovascular health effects of paternal exposure to Electronic Nicotine Delivery Systems (ENDS), an increasingly popular forms of tobacco, namely e-waterpipes and e-cigarettes, by employing a systematic platelet function and related animal model and disease analysis approach. Results obtained from these studies should promote further smoking cessation, as well as lay down the foundation for understanding, and advancing policy and means for evidence-based therapeutic management, prevention and control efforts of tobacco- associated thrombosis-based disease states.

PI_NAMEs: KHASAWNEH, FADI T (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Adult;Animal Diseases;Animal Model;Automobile Driving;Awareness;Biology;Blood Cells;Blood Coagulation Factor;Blood Platelets;Cardiovascular Diseases;cardiovascular health;Cells;Child;clinically relevant;Coagulation Process;Conceptions;Data;Dependence;design;Development;developmental plasticity;Disease;Electronic cigarette;Electronic Nicotine Delivery Systems;Elements;Endothelial Cells;Environmental Risk Factor;Epigenetic Process;evidence base;experimental study;Exposure to;Fathers;Fetal Development;Foundations;Future;Goals;Growth;Health;Hemostatic function;histone modification;hookah;Inflammation;Knowledge;Life;Life Style;Maternal Health;Mediating;Nature;neutrophil;offspring;Onset of illness;Paternal Exposure;Pathogenesis;Phenotype;Placenta;Plasma;Platelet Activation;Platelet Count measurement;platelet function;Policies;Prevention;Public Health;response;Risk;Role;sex;Shapes;Smoke;Smoking;smoking cessation;sperm cell;Stimulus;System;Therapeutic;thrombogenesis;Thrombosis;Time;Tobacco;tobacco control;Tobacco Use Cessation;transcriptome;Untranslated RNA;Work

PROJECT_TITLE: The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis


NIH_SPENDING_CATS: Lung;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Our comprehensive analysis of the rare, but physiologically important pulmonary neuroendocrine cells, identified myriad combination of neuropeptides, neurotransmitters, receptors, and channel genes in individual pulmonary neuroendocrine cells (PNECs), indicating PNECs serve as sentinels to perceive multiple airway stimuli and express a variety of signals that regulate homeostasis. Achieving the aims of this proposal will identify the locations of cells expressing human PNEC peptides and hormones, their expression patterns in neuroendocrine stem cells, and their cellular targets in human tissue. This work is fundamental to developing new treatments and diagnostic strategies across the spectrum of pediatric and adult lung neuroendocrine diseases.

PI_NAMEs: KUO, CHRISTIN SUCHENG (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute;Adult;Afferent Neurons;airway obstruction;Anatomy;Asthma;Brain;Bronchial Tree;Bronchiolitis;cell motility;Cell Proliferation;cell transformation;Cells;cellular targeting;Childhood;Clinical;Clinical Research;Clonal Expansion;Color;combinatorial;Common Core;Coughing;Data;daughter cell;Defect;Development;Diagnosis;diagnostic strategy;Diffuse;Disease;Distal;Dyspnea;Epithelial Cells;epithelial injury;Epithelium;Exhibits;experimental study;Foundations;Future;Genes;genetic approach;Genetic Transcription;Goals;Heterogeneity;Homeostasis;Hormones;Human;human tissue;Hyperplasia;Hypoxemia;Hypoxia;Image;In Situ;In Situ Hybridization;in vivo;Individual;infancy;Injury;Interstitial Lung Diseases;Investigation;Label;Lesion;Ligands;Location;Lung;Lung Diseases;Lung Neuroendocrine Neoplasm;Maps;Measures;Mediating;Methods;Modeling;Molecular;Molecular Profiling;molecular subtypes;Monitor;mouse model;Mus;nerve supply;Neuroendocrine Cell;neuroendocrine differentiation;Neuropeptides;Neurosecretory Systems;Neurotransmitter Receptor;Neurotransmitters;novel diagnostics;novel therapeutic intervention;Pathologic;Patients;Pattern;Peptide Receptor;Peptides;Physiological;Population;Preneoplastic Conditions;programs;Proliferating;Pulmonary Edema;receptor;receptor expression;Regional Anatomy;repaired;Resolution;respiratory;Respiratory Disease;Respiratory physiology;Respiratory Signs and Symptoms;response to injury;Role;sensor;Sensory;Sentinel;Signal Transduction;single molecule;single-cell RNA sequencing;Site;Slice;stem cell expansion;stem cell population;stem cells;Stimulus;System;Testing;Three-Dimensional Imaging;Trachea;transcriptome;transcriptomics;United States;Visualization;Work

PROJECT_TITLE: Identifying and characterizing human pulmonary neuroendocrine stem cells and their diversity

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Genetics;Hematology

ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project narrative: This grant application proposes to study how histone deacetylase 1 (HDAC1), an important epigenetic regulator for eukaryotic gene transcription, controls erythropoiesis through regulating a key transcription factor, GATA-1.

PI_NAMEs: QIU, YI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acetylation;Adult;Affect;Alanine;Antineoplastic Agents;Applications Grants;Arginine;Attenuated;Binding;Cell Physiology;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Complex;Deacetylation;Defect;Development;differentiation in vitro;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Erythrocytes;Erythroid Cells;erythroid differentiation;Erythropoiesis;Fetal Hemoglobin;GATA1 gene;Gene Activation;Gene Expression;Gene Expression Profile;gene repression;Genes;genetic corepressor;Genetic Transcription;Genome;Globin;HDAC1 gene;HDAC4 gene;Hematopoiesis;Histone Deacetylase Inhibitor;In Vitro;insight;Knock-in Mouse;Lead;Learning;Lysine;Mediating;Megakaryocytes;mouse model;Mus;mutant;Mutation;novel;NuRD complex;programs;promoter;Proteins;Proteomics;recruit;Reporting;Repression;Role;Site;transcription factor;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: Epigenetic regulation of erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed research is relevant to public health because it will lead to the understanding of unexplored pathways of congenital heart disease (CHD) and the development of appropriate treatment for CHD. Identifying the cause of CHD will help mitigate the development of this genetic disease to build healthier lives for individuals born with CHD and the potential benefit of preventing CHD.

PI_NAMEs: LIN, JIUANN-HUEY IVY (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adult;Affect;Alleles;atrioventricular septal defect;Cardiac;Cardiac ablation;cardiogenesis;Cardiovascular system;Cell Lineage;cell motility;Cells;Chemicals;Clinical Management;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;conditional knockout;Congenital Abnormality;congenital heart abnormality;Congestive Heart Failure;Cre driver;Data;Defect;Development;Disease;disease model;disease phenotype;Dominant Genetic Conditions;Double Outlet Right Ventricle;Embryo;Ensure;Epidermal Growth Factor;Ethylnitrosourea;Exhibits;experimental study;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Heterogeneity;Genetic Predisposition to Disease;Genetic Screening;Heart;heart cell;heart disease prevention;Heart failure;Heterozygote;hindbrain;Human;human disease;implantation;In Vitro;in vivo;Inbred Mouse;Individual;insight;Knock-in Mouse;Knock-out;Knockout Mice;LDL-Receptor Related Protein 1;Lipoprotein Receptor;LoxP-flanked allele;Maps;Mesenchymal;migration;Missense Mutation;Molecular;Morbidity - disease rate;mortality;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;mutation screening;neonate;Neural Crest;Neural Crest Cell;Neural tube;Nitrosourea Compounds;novel;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pediatric Cardiac Genomics Consortium;Pediatric Hospitals;Penetrance;Phenotype;Population;prenatal;prevent;protein transport;Proteins;Public Health;receptor;recessive genetic trait;Recovery;Reporter;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Supporting Cell;targeted treatment;Time;trafficking;transcriptomic profiling;United States;Variant;Ventricular Septal Defects

PROJECT_TITLE: Multi-Lineage Modulation of cardiac neural crest cells during cardiac development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDD-Q(81)]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Lung;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sleep Research;Telehealth

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The underlying behavioral mechanisms that contribute to a higher likelihood of successful and sustainable increases in adherence and daily physical activity in chronic obstructive pulmonary disease (COPD) patients participating in pulmonary rehabilitation (PR) programs are not understood. We believe that modifiable habitual behavioral patterns play a significant mitigating role in slowing the progression of COPD symptoms. This project will bridge these mechanistic gaps in knowledge to allow us to better refine and individualize our novel home-based PR program to optimize improvements in physical activity and subsequent health benefits across the COPD population.

PI_NAMEs: FORTUNE, EMMA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adherence;Adult;Affect;aging population;Algorithms;Behavioral;Behavioral Mechanisms;Chronic Obstructive Pulmonary Disease;clinical diagnosis;clinical practice;Cognitive;comorbidity;Data;disability;Dyspnea;Effectiveness;Exercise;exercise intervention;Exhibits;Fatigue;Fortune;Goals;Health;Health Benefit;high risk;Home;improved;innovation;Intervention;Knowledge;Longitudinal Studies;Measurement;Measures;Mediation;middle age;Modification;Moods;negative mood;novel;Outcome;Participant;Patient Participation;Patients;Pattern;persistent symptom;Physical activity;Physical assessment;Physical Function;Play;Population;Prevalence;Process;programs;pulmonary rehabilitation;Quality of life;Randomized;Recommendation;reduce symptoms;remote monitoring;Role;sedentary;sedentary lifestyle;Self Efficacy;Sleep;sleep behavior;Sleep disturbances;sleep pattern;sleep quality;Stress;Surveys;Symptoms;telephone coaching;Time;Translating;treatment as usual;wearable sensor technology;Wrist

PROJECT_TITLE: The Impact of Underlying Behavioral Mechanisms on a Home-Based Pulmonary Rehabilitation Program

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Cardiovascular;Hypertension;Kidney Disease;Microbiome;Women's Health Research

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Hypertension is the number one risk factor for cardiovascular disease, which is the leading cause of death worldwide; salt-sensitive hypertensive patients have a 3-fold higher risk of developing cardiovascular disease. We know that the gut microbiota and the immune system are linked and play critical roles in salt-sensitive hypertension in males, but this is largely understudied in females. The present studies will address this significant knowledge gap in our understanding of sex differences in salt-sensitive hypertension by investigating previously unrecognized gut microbiota- and immune-related mechanisms in both salt-sensitive rats and human samples, aiding in the development of more effective, sex-specific therapeutics for the control of blood pressure and kidney disease.

PI_NAMEs: ABAIS-BATTAD, JUSTINE M (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Ablation;Address;American;Amines;Antibiotics;Bioenergetics;Biological;Blood Pressure;blood pressure control;blood pressure regulation;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Carnitine;Cause of Death;Cell Physiology;Choline;cohort;Colon;Correlative Study;cytokine;Dahl Hypertensive Rats;Data;Development;Disease;Disease Progression;Exhibits;Experimental Models;experimental study;fecal microbiota;Feces;Female;Fermentation;Fiber;Genetic;Grant;gut microbiota;high risk;Hormones;Human;Hypertension;hypertensive;Immune;Immune system;Immunity;immunoregulation;improved;Injury to Kidney;Intervention;Kidney;Kidney Diseases;Knowledge;Link;male;Mediating;Mediator;men;microbial;microbiota;microbiota composition;microbiota metabolites;Modeling;novel;novel therapeutics;Organ;Oxides;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Physiological;Play;Population;pre-clinical;Pre-Clinical Model;Premenopause;Production;Propionates;Rattus;renal damage;Research Design;Role;salt sensitive;salt sensitive hypertension;Sampling;Serum;Severities;Severity of illness;sex;Sex Differences;sexual dimorphism;Sodium Chloride;T cell infiltration;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Translating;translational study;Twin Multiple Birth;Twin Studies;Urine;Volatile Fatty Acids;Woman;women versus men;Women's study;Work

PROJECT_TITLE: Sex Differences in Gut Metabolite-Immune Interplay in Hypertension and Renal End-Organ Damage

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Prevention;Sleep Research;Stroke

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Most (70%) SAH participants in our prior study experienced sleep disturbance, thus, a tailored intervention focused on sleep self-management is a critical step for improving their health. This study has high potential for offering a cost-effective intervention that could be implemented on a large scale to improve sleep and quality of life in SAH survivors. If effective, our technology-based intervention may be easily translated to clinical practice for SAH survivors and could be easily modified for other at-risk clinical populations.

PI_NAMEs: BYUN, EEESEUNG  (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: acceptability and feasibility;Accounting;actigraphy;Address;Adult;Age;Age Years;Area;Beds;Behavior;Behavioral;behavioral sleep intervention;Biological;Caregivers;Caring;Chronic Disease;Clinic Visits;Clinical;clinical care;clinical practice;clinical risk;Cognitive;Cognitive deficits;cost effective intervention;cost estimate;daily functioning;Data;design;Development;digital;drinking;Drowsiness;Eating;Economics;effective intervention;Employment;Enrollment;Environment;Event;Exercise;exercise intensity;experience;falls;Fatigue;Friends;Frustration;Geography;handheld mobile device;Health;Health Personnel;Health Promotion;health training;Healthcare;High Prevalence;HIV;Human;human centered design;Impaired cognition;Impairment;improved;improvement on sleep;innovation;Internet;Intervention;intervention refinement;Interview;Knowledge;Life;Life Style;Literature;Measures;Mental Health;Methods;motor impairment;Outcome;Participant;Patient Self-Report;Patients;Performance at work;Personal Satisfaction;Persons;Phase;physical conditioning;Population;programs;Protocols documentation;Qualitative Methods;Quality of life;Randomized, Controlled Trials;Reduce health disparities;Relaxation;Reporting;Research;Research Personnel;Research Project Grants;Resources;routine screening;Self Management;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Social support;Specialist;Stroke;stroke survivor;Structure;Subarachnoid Hemorrhage;success;successful intervention;Survivors;Symptoms;System;Tablet Computer;Techniques;Technology;technology intervention;Testing;Time;Training;Translating;United States;usability;willingness;Work;years of life lost;young adult

PROJECT_TITLE: Technology-based Sleep Self-Management Intervention for Adults with Subarachnoid Hemorrhage

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Vascular injuries from endovascular procedures can cause smooth muscle cell dysfunction, leading to neointimal hyperplasia and ultimately stenosis. This project seeks to combat this by developing a lesion-targeted RNA nanotherapeutic, which delivers the transcripts of lncRNA CARMN to restore smooth muscle cell functions and reduce neointima formation. The insights gained from this study could pave the way for innovative strategies to treat stenotic vascular diseases and improve the outcome of medical interventions.

PI_NAMEs: WANG, MARK KUEI-CHUN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Address;American;Anastomosis - action;Angioplasty;antiproliferative drugs;Arteries;artery stenosis;Attenuated;Biodistribution;Biological Assay;Biological Process;Biomimetics;Blood flow;Blood Platelets;Blood Vessels;Cardiac;Cardiac ablation;Carotid Arteries;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Circulation;Clinical;combat;cytokine;Development;Disease;disease model;Dose;Drug Kinetics;Effectiveness;Enhancers;Ensure;Evaluation;Exposure to;Face;Foundations;Functional disorder;Gene Expression;gene function;Genes;Genetic;Genetic Transcription;Health;hemodynamics;Human;Hyperplasia;improved;improved mobility;improved outcome;In Vitro;in vivo;Inflammatory;injured;Injury;innovation;insight;Intervention;intravenous administration;Investigation;Knock-out;Lesion;Life;Link;Maintenance;Mediator;Medical;Membrane;Mesoderm;Messenger RNA;migration;Modeling;mouse model;Mus;Myopathy;nanoparticle;Nanotechnology;nanotherapeutic;neointima formation;novel strategies;Nuclear;Nuclear Localization Signal;Nuclear RNA;Operative Surgical Procedures;Outcome;overexpression;Pathologic;Peptides;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Phenotype;Play;post intervention;prevent;Procedures;Proliferating;Rattus;Regulation;Research;Research Project Grants;response;restenosis;restoration;RNA;Rodent;Role;Series;Site;Smooth Muscle;Smooth Muscle Myocytes;Solid;Stenosis;Stents;System;targeted delivery;Testing;Therapeutic;therapeutic RNA;Time;Tissues;Toxic effect;Toxicology;Transcript;transcriptome sequencing;Treatment Efficacy;Untranslated RNA;uptake;Vascular Diseases;vascular injury;Vascular Smooth Muscle;Vascular System;Wild Type Mouse

PROJECT_TITLE: Development of lesion-targeted lncRNA nanotherapeutic for vascular smooth muscle dysfunction

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Right ventricular failure is characterized by an increase in deposition of extracellular matrix (ECM) because of cardiac fibroblast differentiation into myofibroblasts. We have evidence showing that alternative polyadenylation (APA) events lead to global 3’UTR shortening of fibrosis genes allowing them to evade micro RNA regulation and thus increasing their translation. An understanding of how APA regulators enhance 3’UTR shortening of fibrotic mediators may lead to identification of a new therapeutic target in right ventricular failure.

PI_NAMEs: AMIRTHALINGAM THANDAVARAYAN, RAJARAJAN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3' Untranslated Regions;4 hydroxynonenal;adduct;aldehyde dehydrogenases;Aldehydes;Amino Acids;Attenuated;Binding Sites;Cardiac;Cardiovascular Diseases;Clinical;coronary fibrosis;Data;Deposition;design;Development;Down-Regulation;Enzymes;Etiology;Event;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Genes;Genetic;Impairment;improved;In Vitro;in vivo;knock-down;Lead;Length;Lipid Peroxidation;Mass Spectrum Analysis;Mediating;Mediator;Messenger RNA;MicroRNAs;Modeling;Molecular;molecular modeling;mortality;Mus;mutant;Myofibroblast;new therapeutic target;novel;Outcome;overexpression;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway Analysis;Patients;pharmacologic;Polyadenylation;Process;Production;protein expression;Proteins;Public Health;Pulmonary Hypertension;Pulmonary Vascular Resistance;Rattus;receptor;Regulation;Regulatory Element;Research;restoration;right ventricular failure;Right Ventricular Function;right ventricular remodeling;Role;Site;Site-Directed Mutagenesis;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;Transcript;Translations;Up-Regulation;Validation;Ventricular

PROJECT_TITLE: Alternative polyadenylation in Right Ventricular Fibrosis

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Human heart has limited capacity for regeneration and repair post heart attacks due to the low exchange rate in cardiomyocytes throughout life. It is largely unknown how adult cardiomyocytes may be induced to cell cycle reentry thus replenish the cellular loss during cardiovascular diseases. This research will define the roles of the previously uncharacterized factor C5ORF51/RIMOC1 and its novel regulatory function in cardiomyocyte homeostasis and heart function. This research is relevant to the public health because it will reveal a novel mechanism contributing to myocardial loss and heart failure. The proposed research is rele- vant to the NIH mission because it will promote fundamental understanding and potential mechanisms con- tributing to cardiomyocyte turnover and maturation thereby promoting disease prevention and treatment.

PI_NAMEs: LIU, RUYA  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acceleration;Address;Adult;Binding;Binding Sites;Bioenergetics;Biological;Biological Process;Biology;Birth;Calcium;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomegaly;Cardiovascular Diseases;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Line;Cell Maturation;Cell Nucleus;Cells;cofactor;Cytokinesis;Development;Dilated Cardiomyopathy;Diploidy;disorder prevention;DNA;DNA Binding;Endowment;Enhancers;Entropy;fetal;Functional disorder;gain of function;Gatekeeping;Gene Activation;Gene Expression;Genes;Genetic Transcription;Goals;Heart;heart dimension/size;Heart failure;heart function;Heart Injuries;Homeostasis;Human;Impairment;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Injury;innovation;interest;Knock-out;Knockout Mice;Knowledge;Life;loss of function;Mediating;Mission;Mitosis;Modality;Modeling;Molecular;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;Myocardial Infarction;Nature;Neonatal;neonatal mice;Nodal;novel;Nucleic Acid Regulatory Sequences;Pathway interactions;Pattern;Play;Ploidies;Population;postmitotic;Premature Mortality;prevent;primitive cell;programs;Proliferating;Proteins;Public Health;Recovery of Function;Regenerative capacity;regenerative therapy;Regulation;repaired;Research;Role;screening;Signal Transduction;Specific qualifier value;Testing;transcription factor;transcriptome sequencing;United States National Institutes of Health

PROJECT_TITLE: C5ORF51 - a Novel Regulator of Cardiomyocyte Function and Homeostasis


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Summary Cardiovascular disease is the leading cause of death in the United States with ventricular arrhythmias being a major source of morbidity and mortality in patients with structural heart disease. This proposal seeks to develop and investigate the role of non-invasive cardiac stereotactic body radiation therapy (cSBRT) for the treatment of patients with refractory lethal ventricular arrhythmias.

PI_NAMEs: TSCHABRUNN, CORY MICHAEL (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Anatomy;Animal Model;Animals;Anti-Arrhythmia Agents;Area;Arrhythmia;Body Surface;Cardiac;Cardiac ablation;Cardiac Electrophysiologic Techniques;cardiac magnetic resonance imaging;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cessation of life;Chronic;Cicatrix;Clinical;clinical efficacy;clinical practice;Clinical Research;clinically relevant;comparison control;Complex;Data;Disease;Dose;Electrocardiogram;Electrophysiology (science);Evaluation;experimental study;Failure;Family suidae;Fibrosis;follow-up;Follow-Up Studies;Foundations;Functional disorder;Future;Gap Junctions;Goals;Heart;Heart Diseases;heart function;High Prevalence;Human;Image;Implantable Defibrillators;Implantation procedure;improved;Incidence;Infarction;innovation;Left;Left Ventricular Ejection Fraction;Life;Longterm Follow-up;Magnetic Resonance Imaging;Maps;Measures;Molecular;Morbidity - disease rate;mortality;Myocardial Infarction;non-invasive imaging;novel therapeutics;Patient Selection;Patients;Pharmacotherapy;Photons;porcine model;preclinical study;prevent;Procedures;programs;Publishing;Radiation;Radiation Dose Unit;Radiation therapy;Reaction Time;Recurrence;Refractory;Registries;Resolution;response;Risk Reduction;Role;Series;Shock;Source;structural heart disease;Structure;success;sudden cardiac death;targeted treatment;Techniques;Technology;Time;Tissues;United States;Ventricular;Ventricular Arrhythmia;Ventricular End-Diastolic Volumes;Ventricular Fibrillation;Ventricular Tachycardia;voltage

PROJECT_TITLE: Determining the Mechanisms of Radiation Biomodulation of the Ventricular Tachycardia Arrhythmogenic Substate

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Projective Narrative Examining biopsychological mechanisms through which psychosocial stress contributes to poor cardiometabolic health in older Asian American immigrants is a critical area for public health, as cardiometabolic diseases are leading causes of death among Asian American immigrants. This study aims to investigate the psychosocial and cultural determinants of cardiometabolic health and key biopsychological processes underlying these relationships using a prospective design. Study results will inform future culturally- tailored public health interventions to promote cardiometabolic health for older Asian American immigrants.

PI_NAMEs: JIANG, YANPING  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acculturation;Address;Adult;Affect;aged;Area;Asian;Asian Americans;Blood Pressure;blood pressure elevation;Buffers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cause of Death;Cessation of life;Chinese;Chinese American;Data;Data Collection;design;Discrimination;Disease;Dyslipidemias;Ecological momentary assessment;effective intervention;Emotions;epidemiology study;experience;Female;follow-up;Future;Glycosylated hemoglobin A;Goals;Health;Heterogeneity;high risk;Hydrocortisone;Hypertension;Immigrant;indexing;Individual;insight;Intervention;Knowledge;Language;low socioeconomic status;marginalization;Measures;Mediation;metropolitan;Minority;Modeling;multilevel analysis;multimodality;Neighborhoods;New York;Non-Insulin-Dependent Diabetes Mellitus;novel;Older Population;Outcome;Participant;Pathway interactions;Penetration;personalized intervention;physical inactivity;Physiological;Population;Process;prospective;psychosocial;Psychosocial Stress;psychosocial stressors;Public Health;public health intervention;racism;Research;response;Risk Factors;Role;Saliva;Salivary;Sampling;sleep quality;social cohesion;social culture;social engagement;Social Interaction;Social isolation;Social support;sociocultural determinant;Stereotyping;Stress;Testing;Time;Treatment/Psychosocial Effects;Unhealthy Diet;United States National Institutes of Health;Work

PROJECT_TITLE: Psychosocial and cultural determinants of cardiometabolic health among older Chinese Americans

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: PROJECT NARRATIVE Heart failure in the presence of diabetes is common and deadly. While commonly thought of as occurring in the left side of the heart, right ventricular (RV) dysfunction is also present in diabetes and contributes to poor health outcomes. The purpose of this proposal is to identify the mechanisms of RV dysfunction in diabetes with the long-term goal of identifying new therapies for the failing RV.

PI_NAMEs: BRUNS, DANIELLE REULAND (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: antioxidant enzyme;Biology;Cardiomyopathies;Cardiovascular Diseases;CD36 Antigens;CD36 gene;Clinical;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Disease;fatty acid metabolism;Fatty Acids;functional decline;Functional disorder;Future;gain of function;Genetic;Genetic Models;glucose uptake;Goals;Heart;Heart failure;Impairment;improved;innovation;Insulin Resistance;Investigation;Left;Left Ventricular Dysfunction;Left Ventricular Function;Left ventricular structure;Link;loss of function;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;molecular phenotype;mortality;Myocardial;Myopathy;Needles;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;overexpression;oxidative damage;Oxidative Stress;Pathogenesis;Pathologic;Patient-Focused Outcomes;Patients;poor health outcome;Production;Public Health;Reactive Oxygen Species;Reporting;Research;Research Personnel;Resolution;response;Right Ventricular Dysfunction;Right Ventricular Function;right ventricular remodeling;Right ventricular structure;Side;Signal Transduction;SOD2 gene;Spirometry;Testing;Therapeutic;uptake;Ventricular;Ventricular Remodeling

PROJECT_TITLE: Mechanisms of right ventricular dysfunction in type 2 diabetes

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The primary goal of this application is to understand how a crucial family of cardiac voltage-activated cation channels sense membrane voltage, which will potentially lead to new targets of treatment for heart diseases especially arrhythmias. Using advanced electrophysiology and fluorescence imaging methods, our experiments will provide mechanistic insights into disease-associated mutations of this family of ion channels and strategies for cardiac arrhythmia therapy.

PI_NAMEs: DAI, GUCAN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Affect;Amino Acids;Arrhythmia;Atrial Fibrillation;Attention;Behavior;Binding;biophysical techniques;Bypass;Cardiac;Cardiomyopathies;Cations;Characteristics;Chemistry;comparative;Coupling;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;delayed rectifier potassium channel;Disease;electrical property;Electrocardiogram;Electrophysiology (science);Ethers;Exhibits;experimental study;Family;Fluorescence;Fluorescence Anisotropy;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fluorometry;Foundations;Frequencies;Genes;Goals;Heart;Heart Arrest;Heart Atrium;Heart Diseases;Heart failure;heart rhythm;Heterogeneity;Homo;Human;Human Cell Line;Hydrogen Bonding;imaging approach;imaging modality;improved;Inherited;insight;Ion Channel;Ion Channel Gating;Ions;Kinetics;Knowledge;Label;Lead;Link;Long QT Syndrome;Measurement;Measures;Mediating;member;Membrane;Methodology;Methods;Modeling;Molecular Computations;Molecular Conformation;molecular dynamics;Movement;Mutation;Myocardial;Nature;Pacemakers;patch clamp;Phase;Physiology;Play;Potassium Channel;Process;Recombinants;Risk;Role;sensor;Shapes;Signal Transduction;Sinoatrial Node;Site;Structure;sudden cardiac death;Syndrome;Techniques;Testing;Therapeutic;Time;Transition Elements;Translating;Ventricular Arrhythmia;voltage;voltage gated channel

PROJECT_TITLE: ELECTROMECHANICAL COUPLING AND DISEASE MECHANISMS OF MYOCARDIAL CNBD FAMILY CHANNELS

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Health Services;Heart Disease

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The proposed research is relevant to public health because it will clarify and strengthen the currently ambiguous treatment recommendations for guideline-directed medical therapies in heart failure with mid-range ejection fraction. As such, clinicians will then have clearer tools to reduce mortality for individuals with this phenotype of heart failure. Thus, the work proposed here is highly relevant to the part of the NHLBI’s mission to promote the treatment of heart disease and enhance the health of all individuals.

PI_NAMEs: WASFY, JASON HARMON (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;adjudication;Adrenergic beta-Antagonists;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;antagonist;Clinical;Clinical Data;Clinical Practice Guideline;Community Hospitals;comorbidity;comparative effectiveness;Comparative Effectiveness Research;Data;Data Aggregation;Defibrillators;Echocardiography;Economics;Effectiveness;EFRAC;Ensure;Frequencies;Future;Glucose;Goals;Guidelines;Health;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;Hospitals;Image;improved;Individual;Influentials;inhibitor;innovation;Left Ventricular Ejection Fraction;Link;Manuals;Mathematics;Measurement;Measures;Medical;Methods;Mineralocorticoid Receptor;Mission;mortality;multimodality;National Heart, Lung, and Blood Institute;Natural Language Processing;Needs Assessment;Neprilysin;novel;Observational Study;Outcome;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Population;Primary Prevention;prospective;Public Health;Recommendation;Registries;Reporting;Research;Resources;Scoring Method;Side;Sodium;Structure;Subgroup;symporter;Testing;Therapy trial;tool;treatment effect;Treatment Failure;treatment guidelines;treatment strategy;United States;Work

PROJECT_TITLE: Effectiveness of Therapies for Heart Failure with Mid-Range Ejection Fraction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DENTON

ORG_NAME: UNIVERSITY OF NORTH TEXAS

PHR: PROJECT NARRATIVES This study will develop a comprehensive human organoid-artificial intelligence (AI) system for assessing tyrosine kinase inhibitors (TKI)-induced cardiotoxicity, increasing the efficiency and accuracy of preclinical drug safety evaluation in both cardiovascular structure and function. The preliminary assessment results will redefine or suggest existing FDA-approved TKIs in clinical practice, and further extend the organoid-AI system’s applications in assessing new TKIs and other general drugs with potential cardiotoxicity concerns.

PI_NAMEs: YANG, HUAXIAO  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Action Potentials;Address;Animals;antitumor effect;Arrhythmia;Artificial Intelligence;artificial intelligence algorithm;Calcium;Cancer Patient;cancer therapy;Cardiac;Cardiotoxicity;cardiovascular effects;cardiovascular imaging;Cardiovascular Physiology;Cardiovascular system;Categories;Cell Line;Cell Survival;Cells;Cellular Structures;Classification;clinical application;clinical development;clinical diagnosis;clinical practice;Color;Congestive Heart Failure;Data;Data Analyses;Development;directed differentiation;Double-Blind Method;drug discovery;Drug Evaluation;Drug Industry;Drug toxicity;Evaluation;experimental study;Expert Systems;Failure;FDA approved;Fluorescence;fluorescence imaging;Functional disorder;Generations;generative adversarial network;generative artificial intelligence;Goals;Heart;Heart Abnormalities;Human;human model;human pluripotent stem cell;Hypertension;In Vitro;Individual;Ischemia;Label;large datasets;Left Ventricular Dysfunction;live cell imaging;machine learning algorithm;Malignant Neoplasms;Measurable;Measurement;Measures;medication safety;Molecular;Myocardial Infarction;network models;Nitric Oxide;novel;Organoids;Pattern;Pharmaceutical Preparations;Phenotype;pre-clinical;preclinical trial;Production;Property;Protein Tyrosine Kinase;Proteomics;Reactive Oxygen Species;Reporter;Reporter Genes;response;small molecule inhibitor;Specific qualifier value;Structure;System;Therapeutic;Toxic effect;Training;transcriptome sequencing;Tyrosine Kinase Inhibitor;Vascularization;Visualization

PROJECT_TITLE: Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI System

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Diabetics are more likely to have a stroke, have greater brain injury after ischemia, and have compromised recovery. Given that the principal cause of these outcomes in people with diabetes is vascular damage, a critical barrier to our progress in reducing morbidity and mortality is understanding how diabetes affects the integrity of the cerebral vasculature. We hypothesize that in diabetes, cerebrovascular O-GlcNAcylation, a post-translational modification that alters target protein function, activity, subcellular localization, and stability, is a novel and causal mechanism of the increased predisposition, aggravated neurovascular injury, and impaired recovery after stroke.

PI_NAMEs: MCCARTHY, CAMERON  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Ablation;Acute;Address;Affect;basilar artery;Behavior;behavior test;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;Brain Injuries;Brain Ischemia;Calcium;Cells;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Chronic;Cognitive;Cognitive deficits;cost;Coupled;Dependovirus;Diabetes Mellitus;diabetic;Disease;Dose;Endothelial Cells;Enzymes;Exposure to;Functional disorder;Functional impairment;Gene Expression;Glucose;High Fat Diet;Hospitalization;Hyperglycemia;Impairment;improved;In Vitro;in vivo;Infarction;Inflammatory;insight;Ischemia;Knock-out;Link;Literature;Measurement;Mechanics;Methods;middle cerebral artery;Middle Cerebral Artery Occlusion;migration;Modeling;Modification;Morbidity - disease rate;Morphology;mortality;Mus;neovascularization;neurovascular injury;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;O-GlcNAc transferase;Obesity;Outcome;Palmitates;parenchymal arterioles;Pathologic;Patients;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Permeability;Persons;post stroke;Post-Translational Protein Processing;Predisposition;Proliferating;protein expression;protein function;Proteins;Proteomics;Public Health;Recovery;Recovery of Function;repaired;Reporting;Research;Research Personnel;response;Role;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Streptozocin;Stress;Stroke;Stroke prevention;stroke recovery;stroke risk;Structure;Testing;therapeutic target;Vascular Diseases;Vascular Endothelium;Vascular Smooth Muscle

PROJECT_TITLE: Cerebrovascular O-GlcNAcylation Worsens Diabetes-associated Neurovascular Injury and Recovery Post-stroke


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative: Corneal pain is an important mechanism to detect injury or damage, leading to protective responses to limit injury if possible (tearing to remove a foreign object), initiate healing and protect the ocular surface required for clear vision. When maladaptive, corneal pain can be so debilitating as to limit daily function, dramatically reduce quality of life, and cause significant economic burden. The proposed research will elucidate the molecular, cellular, anatomical and neurobiological mechanisms of ocular pain and hypersensitivity including photoallodynia by investigating corneal nerves and their responses in non- human disease models of corneal surface injury/dry eye, allergic eye disease and migraine.

PI_NAMEs: MATYNIA, ANNA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Molecular, cellular, anatomical and neurobiological investigation of melanopsin-expressing corneal innervation, and its role in pain and photophobia


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: OVERALL The Vanderbilt-Ingram Cancer Center SPORE in Breast Cancer has made notable advancements across the spectrum of breast cancer research. With supplemental funding, our primary objective is to conduct collaborative and impactful translational research for those affected by or at risk of breast cancer. We propose to further our research on three translational projects, primarily targeting triple-negative breast cancer, with essential support from three cores: Pathology and Tissue Informatics, Biostatistics and Bioinformatics and Administrative and Engagement; and patient advocates, to ensure that we are inclusive of the patient perspective in meeting our goals.

PI_NAMEs: PARK, BEN HO;PIETENPOL, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Academic Medical Centers;Administrative Coordination;Advocate;Affect;Agonist;Animal Model;Animals;anti-cancer research;Antigen Presentation;Antigen Targeting;Atlases;Bioinformatics;Biometry;Blood specimen;Body Fluids;Breast;Breast Cancer Risk Factor;Cancer Center;Cell Line;CLIA certified;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;Communication;comparison control;Consent;Consult;Data;Data Analyses;data quality;data repository;Databases;Development;Diagnostic;Enrollment;Ensure;Epithelium;Evaluation;Experimental Designs;Fostering;Funding;gene panel;Genes;Genomics;Goals;Histology;Human Resources;Immune;Immunohistochemistry;immunoregulation;Immunotherapy;improved;improved outcome;Informatics;innovative technologies;International;Laboratories;liquid biopsy;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammary Neoplasms;Manuscripts;Medical;meetings;men;Methods;molecular diagnostics;Monitor;multidisciplinary;Mutation;Occupational activity of managing finances;Organoids;Pathologic;Pathology;Patient Participation;Patients;Policies;Process;Productivity;Prognostic Marker;programs;Protocols documentation;Publications;Quality Control;recruit;Regulation;Report (document);Reporting;repository;Reproduction spores;Research;research and development;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Sample Size;Services;Standardization;Tissues;tool;Training;Translational Research;translational study;treatment response;triple-negative invasive breast carcinoma;tumor;United States National Institutes of Health;Woman;Work;Writing

PROJECT_TITLE: SPORE in Breast Cancer


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: OVERALL NARRATIVE Lung cancer remains the leading cause of cancer-related deaths, with more than 1.6 million deaths/year globally. We plan to conduct translational and innovative research to enhance the efficacy of immunotherapy (project 1) and to develop novel molecularly targeted approaches to overcome resistance to treatment (projects 2 and 3) in lung cancer. The Emory Lung Cancer SPORE program brings together an outstanding and multi-disciplinary team of oncologists, immunologists, drug discovery experts, and translational researchers to address critical questions that will improve the outcome for patients with this lethal disease.

PI_NAMEs: FU, HAIAN ;RAMALINGAM, SURESH S (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Address;Administrative Supplement;anti-cancer;anti-cancer research;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;Area;artificial intelligence model;Award;B-Lymphocytes;Biological;biomedical informatics;Biometry;Cancer Etiology;Cancer Patient;cancer therapy;career;CD8-Positive T-Lymphocytes;Cessation of life;Circadian Dysregulation;clinical application;clinical efficacy;Collaborations;Combined Modality Therapy;Comprehensive Cancer Center;Contracts;COVID-19 pandemic;COVID-19 patient;COVID-19 vaccination;COVID-19 vaccine;Data;Dedications;Development;Diagnosis;Disease;Dose;drug discovery;Drug resistance;Epidermal Growth Factor Receptor;exhaustion;experience;flexibility;Funding;Health Sciences;Healthcare Systems;Hematology;Immune checkpoint inhibitor;Immunologic Factors;Immunologist;Immunotherapy;improved;improved outcome;innovation;insight;Institution;Interleukin-2;Journals;KRAS2 gene;Location;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncology;medical schools;member;Memory B-Lymphocyte;MERTK gene;Modernization;Molecular Target;molecular targeted therapies;mortality;multidisciplinary;mutant;Mutate;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncologist;Outcome;Pathology;patient population;Patient-Focused Outcomes;Patients;PD-1 blockade;pembrolizumab;Phenotype;Pilot Projects;Play;programmed cell death protein 1;programs;Property;prospective;Publishing;Recommendation;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;response;Risk Reduction;Role;Scientist;Secondary Immunization;severe COVID-19;Signal Transduction;Site;stem;stemness;STK11 gene;T cell response;T-Lymphocyte;targeted agent;targeted treatment;Testing;therapy resistant;translational goal;translational scientist;treatment and outcome;Treatment Efficacy;tumor;Universities;Work

PROJECT_TITLE: Administrative Supplement: Interim Funding for Emory Lung Cancer SPORE


PHR: PROJECT NARRATIVE This application is a Supplement to support the Vanderbilt-Ingram Cancer Center GI SPORE, which will continue to focus on colorectal cancer, the second leading cause of cancer-related deaths in the United States. We narrowly missed being funded on the A0 submission in September 2023. We are preparing our A1 submission for the imminent September 25, 2024 deadline and we are requesting funds to carry out crucial experiments to continue the trajectory of our 3 Projects and supporting Cores, as well as the salary support of key personnel.

PI_NAMEs: COFFEY, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: Award;Berlin;beta catenin;Bioinformatics;Biological;Biometry;Cancer Center;Cancer Etiology;Cell membrane;Cells;Cessation of life;Clinical;Clinical Trials;Colorectal Cancer;experimental study;Funding;Grant;Human;Human Resources;Institution;Jordan;Lead;Malignant neoplasm of gastrointestinal tract;molecular imaging;Mus;Pathology;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;Protac;Reproduction spores;Research Support;skills;Tissues;tumor initiation;United States;Update;Wages;WNT Signaling Pathway

PROJECT_TITLE: Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Latinos living in the 50 United States (US) have about 1.5 times the risk of Alzheimer’s disease as non-Latino whites with Puerto Ricans representing the Latino background with the highest prevalence of mild cognitive impairment and cardiovascular disease risk factors, both long associated with Alzheimer’s disease and related dementias (ADRD) risk. The overall research and training goals of this K01 center around investigating protective factors to promote healthy cognitive and brain aging in middle-aged and older Latinos (ages 45+) and expand work currently being conducted in the continental US to the US territory of Puerto Rico. Findings may inform the development of culturally-targeted interventions to support healthy cognitive and brain aging in Latinos, the largest racial/ethnic minority group in the US, with a particular focus on Puerto Ricans.

PI_NAMEs: ESTRELLA, MAYRA LORELL (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ancillary Study;Area;Body Composition;Body fat;Brain;brain health;brain magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Central American;Chronic Disease;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive reserve;cohort;Community Health;Cuban;Data;Death Rate;dementia risk;depressive symptoms;Development;Disparity;Disparity population;Dominican;Education;Epidemic;Epidemiology;epidemiology study;ethnic minority;ethnic minority population;Ethnic Origin;executive function;Exhibits;experience;Fatty acid glycerol esters;follow-up;Functional disorder;Funding;Goals;Health;health equity;Health Promotion;Health Sciences;healthy aging;High Prevalence;Hispanic Community Health Study/Study of Latinos;Household;human old age (65+);indexing;insight;Intervention;Investigation;Island;Knowledge;Latino;Latino Population;Magnetic Resonance Imaging;Maintenance;Measures;Memory;Mental Health;Mexican;middle age;mild cognitive impairment;National Heart, Lung, and Blood Institute;Neurocognitive;neuroimaging;Observational Study;Occupations;Participant;Persons;Population;Positioning Attribute;post-doctoral training;programs;protective factors;Protocols documentation;Psychosocial Assessment and Care;Puerto Rican;Puerto Rico;racial minority;racial minority population;Research;Research Personnel;resilience;Risk Factors;Schedule;skills;socioeconomic disadvantage;South American;Structure;Study of Latinos;Testing;theories;Training;trend;Underrepresented Populations;United States;Visit;Work

PROJECT_TITLE: Protective Factors of Cognitive Aging among Latinos in the 50 States and Puerto Rico

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb) is an exquisitely evolved, incredibly successful, and difficult to treat human pathogen that currently infects one-quarter of the world’s population. We discovered that during Mtb infection of macrophages, mitochondrial reactive oxygen species (ROS) licenses a necrotic cell death pathway that promotes hyperinflammation and poor disease outcomes. We predict that blocking this newly described cell death pathway may benefit tuberculosis patients with underlying genetics or conditions that are associated with ROS accumulation.

PI_NAMEs: PATRICK, KRISTIN LEIGH;WATSON, ROBERT OWEN (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acute;acute infection;Alleles;Anti-Bacterial Agents;Apoptosis;Cardiolipins;Catalogs;Cell Death;Cell membrane;cell type;Cells;Cellular biology;Cellular Membrane;Cellular Stress;chronic inflammatory disease;co-infection;comorbidity;Cytolysis;Data;Diabetes Mellitus;Disease;Disease Outcome;Equilibrium;experience;experimental study;Generations;Genes;Genetic;glutathione peroxidase;Goals;Heterogeneity;high risk;HIV;Human;human disease;human pathogen;immunogenic;Immunologics;immunopathology;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Intervention;Leprosy;Licensing;Link;Lipid Peroxidation;Lipids;LRRK2 gene;Lung;Macrophage;Malnutrition;Measures;Mediating;Mediator;member;Mitochondria;mitochondrial dysfunction;Modality;Modeling;mouse model;Mus;Mutation;Mycobacterium tuberculosis;Nature;Necrosis;Neutrophil Infiltration;novel;Outcome;Outer Mitochondrial Membrane;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phospholipids;Phosphorylation;Phosphotransferases;Play;Population;Predisposition;Production;Protein Biochemistry;Protein Family;Proteins;Reactive Oxygen Species;recruit;response;RIPK1 gene;RIPK3 gene;Role;Smoking;Stress;Testing;Therapeutic Intervention;Tuberculosis;tuberculosis immunity;VDAC1 gene;Vitamin K 3;Work

PROJECT_TITLE: Targeting mediators of oxidative stress to limit hyperinflammatory cell death modalities during Mycobacterium tuberculosis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-X(02)]


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

PI_NAMEs: VAZIRI, ASHKAN  (contact)

PROJECT_TERMS: Adipose tissue;Artificial Intelligence;biomedical imaging;Body Composition;Body mass index;Cancer Patient;Classification Scheme;Early identification;Food Aversion;imaging Segmentation;Interview;machine learning model;Malnutrition;Modeling;Muscle;novel;Phase;prototype;Questionnaires;screening;Skeletal Muscle;Small Business Innovation Research Grant;software development;tool;Validation;X-Ray Computed Tomography

PROJECT_TITLE: FY24 SBIR PHASE I TOPIC NO. 459 PROJECT TITLE: AN AUTOMATED SCREENING PLATFORM FOR EARLY IDENTIFICATION OF MALNUTRITION IN CANCER PATIENTS


ACTIVITY: ZIA

ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Microbiome;Neurosciences;Nutrition;Obesity;Prevention;Substance Misuse

PI_NAMEs: JOSEPH, PAULE  (contact)

PROJECT_TERMS: Address;Affect;Age;Area;Behavioral;Blood;chemokine;clinical center;cohort;comorbidity;cytokine;Data Analyses;design;Diet;Dietary Intervention;Eating;Eating Behavior;effective intervention;Enrollment;exosome;Food;food consumption;Fostering;gut microbiota;Hour;improved;Individual;individual variation;Inflammation;inflammatory marker;Institutional Review Boards;Intervention;Investigation;Measures;metropolitan;microbiome composition;microbiota;nasal microbiome;Neurons;Non obese;novel;obese person;Obesity;obesity development;obesity treatment;oral microbiome;Outcome Measure;Participant;pharmacologic;Plasma;prevent;Prevention;primary outcome;Public Health;recruit;Risk Factors;Risk Reduction;screening;secondary outcome;sex;Smell Perception;success;System;Taste Perception;Time;transcriptomics;Unhealthy Diet;United States National Institutes of Health;Variant;Visit;Washington

PROJECT_TITLE: Mechanisms Underlying Individual Variations of Taste and Smell in Obesity


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PROJECT_TERMS: Acute;Address;Adult;Affect;alcohol use disorder;Area;Auditory;behavior influence;Binge Eating;Black race;blood oxygenation level dependent response;Blood Pressure;Body mass index;brain reward regions;Calories;cardiometabolism;Chronic;Clinical;Clinical Protocols;Collaborations;Consummatory Behavior;Consumption;Controlled Environment;COVID-19 impact;Crossover Design;Cues;Desire for food;Diagnosis;Diet;Dietary intake;Disinhibition;Double-Blind Method;Eating;Eating Behavior;Eating Disorders;Esthesia;Exposure to;Food;Functional Magnetic Resonance Imaging;Genetic;Genetic Variation;Genomics;Goals;Health;High Fat Diet;Human;Hunger;Hylobates Genus;Hypertension;improved;Individual;individual variation;Inpatients;interest;International;Journals;Laboratories;lifestyle factors;Link;Literature;Measures;Metabolic Diseases;Metabolic syndrome;Metabolism;metabolomics;microbiome research;Modernization;Molecular;Motivation;multiple omics;multisensory;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Alcohol Abuse and Alcoholism;neural;Neurons;nutrition;Obesity;obesity risk;Outcome;Outpatients;Participant;Pathway interactions;Patient Self-Report;Perception;Persons;Phenotype;Physiological;Play;Population;preference;Process;Questionnaires;Randomized, Controlled Trials;Reporting;Research;response;retention rate;Rewards;Role;Sampling;satisfaction;Science;Sensory;sensory system;Shapes;Smell Perception;Sodium;Sodium Chloride;Stimulus;sugar;sweet taste perception;Taste Buds;Taste Perception;Taste preferences;taste system;transcriptomics;Translational Research;Variant;Waiting Lists;Weight

PROJECT_TITLE: Sensory Science and Metabolism; Molecular and Neuronal Mechanisms


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cannabinoid Research;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Endocannabinoid System Research;Genetics;Liver Disease;Nutrition;Obesity;Substance Misuse

PI_NAMEs: KUNOS, GEORGE  (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;adenylate kinase;Adipocytes;Alcohol consumption;Alcoholic Fatty Liver;Anabolism;antagonist;Biological;Biological Assay;Breeding;Carbohydrates;CB1 knockout;CD36 gene;Cell Line;Cells;Central obesity;Chronic;Cirrhosis;CNR1 gene;Code;Complementary DNA;conditional knockout;Desire for food;Development;Diabetic Nephropathy;Diet;diet-induced obesity;Disease;Endocannabinoids;endogenous cannabinoid system;Energy Intake;Energy Metabolism;Energy-Generating Resources;Enzymes;Excision;Exposure to;extracellular;Extrahepatic;fatty acid oxidation;fatty acid transport;Fatty Acids;fatty liver disease;Fibrosis;Food;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Glucose;Goals;Health;Hemorrhage;Hepatic;Hepatocyte;Heterozygote;High Fat Diet;Homeostasis;homologous recombination;Hybrids;in vivo;Incubated;Individual;interest;Knockout Mice;lipid metabolism;Liver;Luciferases;Manuscripts;marijuana use;Mediating;Metabolic syndrome;meter;Microinjections;Minor;Mitochondria;Modeling;Mus;Mutant Strains Mice;nano-string;Non obese;non-alcoholic fatty liver;Non-Insulin-Dependent Diabetes Mellitus;NOS2A gene;novel;Obese Mice;Obesity;offspring;Oleic Acids;Oxygen Consumption;Pathway interactions;Pattern;Peripheral;Phosphorylation;Play;prevent;Primary carcinoma of the liver cells;Probability;Process;programs;promoter;protein expression;Proteins;Pulmonary Fibrosis;receptor;Recombinants;Regulation;Reporter;Reporting;Resistance;Respiration;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Pathway;Signal Transduction;Site;skin fibrosis;Source;stable cell line;stem cells;Technology;Terminator Codon;Testing;Thinness;Threonine;Time;transcriptome sequencing;Transfection;Transgenic Organisms;translocase;Treatment Efficacy;Triglycerides;uptake;Weight Gain;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Endocannabinoids And Energy Homeostasis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: RAMCHANDANI, VIJAY ARJUN (contact)

PROJECT_TERMS: acute stress;addiction;Affect;Age;Agonist;Alcohol abuse;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol cue;alcohol effect;alcohol exposure;alcohol misuse;alcohol response;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Algorithms;Annual Reports;anxiety symptoms;bariatric surgery;Behavior;Behavior assessment;Behavioral;binge drinking;biobehavior;Biological Markers;Brain;Categories;Cholinergic Receptors;Classification;Clinical;Clinical Data;Clinical Pharmacology;Clinical Trials;Closure by clamp;Collaborations;Complement;Computer Assisted;Consumption;consumption measures;Coping Behavior;Coping Skills;COVID-19;COVID-19 pandemic effects;craving;Cues;Data;depressive symptoms;Development;Dimensions;disorder risk;Disparate;domain mapping;drinking;Drug Kinetics;emotional functioning;Enrollment;Etiology;executive function;Face;Family history of;flexibility;Fright;Functional Magnetic Resonance Imaging;Future;Genes;Genetic;genomic data;ghrelin;Goals;health disparity;hedonic;Height;Heterogeneity;Human;Image;image translation;imaging genetics;Impairment;improved;Impulsivity;incentive salience;Individual;Infusion procedures;insight;inter-individual variation;Intoxication;Intravenous;intravenous administration;Intravenous infusion procedures;Ketones;Laboratories;Link;Loneliness;Longitudinal Surveys;male;Measures;Mediator;Medicine;Mental Depression;Mental Health;Methodology;Methods;Modeling;mood symptom;Motivation;nalmefene;National Institute on Alcohol Abuse and Alcoholism;Natural History;negative affect;Negative Valence;neural;Neurobiology;Neuropsychology;Nicotinic Receptors;novel;novel therapeutics;Nucleus Accumbens;Occupations;Opioid Antagonist;Opioid Receptor;Outcome;pandemic disease;Paraosmias;Perception;Personal Satisfaction;personalized medicine;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phenotype;Physiological;Placebos;post-pandemic;preclinical study;Property;prospective;psychologic;Psychophysiology;Public Health;Publishing;Questionnaires;Receptor Gene;Recording of previous events;Reporting;Research;research clinical testing;Research Personnel;response;Rewards;Risk;Risk Factors;Role;Self Administration;Severities;sex;smoking cessation;social;social media;Stimulus;Stress;stressor;Structure;System;targeted treatment;Testing;Therapeutic;Time;transcriptomics;translational study;varenicline;Variant;Weight;Withdrawal;Work;young adult

PROJECT_TITLE: Alcohol Pharmacokinetics and Pharmacodynamics in Humans


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: HAMMOUD, DIMA A (contact)

PROJECT_TERMS: animal data;Blinded;Brain;Data Analyses;Exposure to;Functional disorder;Hand;HIV;HIV Infections;HIV Seronegativity;Human;Image;Infection;Institutional Review Boards;Manuscripts;Molecular;neuron loss;Neurotransmitters;Paper;Patient Recruitments;Patients;Positron-Emission Tomography;postsynaptic;presynaptic;Protocols documentation;Publishing;Rat Transgene;recruit;Scanning;socioeconomics;System;Thalamic structure;Update;uptake;Viral Proteins;Writing

PROJECT_TITLE: PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients


PROJECT_TERMS: 2019-nCoV;ACE2;Acids;Acute Lung Injury;Address;Affinity;Aftercare;Albumins;alveolar epithelium;animal imaging;Animal Model;Animals;aspirate;Binding;Binding Sites;Biological Assay;Blood;Bone Marrow;Brain;cecal ligation puncture;Cells;central nervous system injury;Characteristics;Collaborations;COVID-19;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Down-Regulation;Drug Kinetics;Ebola;Ebola virus;Endothelium;experimental study;Extravasation;Functional disorder;Genes;Goals;HIV;HIV Envelope Protein gp120;HIV Infections;Human;Image;imaging modality;improved;in vivo;in vivo imaging;Infection;K-18 conjugate;Knockout Mice;Label;Lassa;Lassa virus;Ligands;Lipopolysaccharides;Lung;lung injury;Magnetic Resonance Imaging;Manuscripts;Marburgvirus;Measurement;Mediating;Methods;microPET/CT;Modeling;Molecular Biology;molecular imaging;Molecular Target;mouse model;Mus;nanobodies;nanolabel;National Heart, Lung, and Blood Institute;natural antibodies;Nature;Nipah;Nipah Virus;non-invasive imaging;Organ;Pathology;Peripheral;Positron-Emission Tomography;Process;protective pathway;Proteins;Publications;Publishing;Pulmonary Pathology;Radiolabeled;receptor;Recombinants;research facility;Research Personnel;response;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Severities;Site;Spleen;Testing;Therapeutic Intervention;Tissues;tumor;Type II Epithelial Receptor Cell;Viral;Virus;Virus Diseases;Virus Replication;Wild Type Mouse;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Molecular imaging of viral infections


PI_NAMEs: WOOD, BRADFORD  (contact)

PROJECT_TERMS: Ablation;Address;Adopted;Adoption;Anatomy;Annual Reports;anti-cancer research;anti-cancer therapeutic;anti-cancer treatment;Antineoplastic Agents;Area;artery occlusion;Artificial Intelligence;artificial intelligence model;Augmented Reality;Automation;Beds;bench to bedside;Biological Markers;Biopsy;Bronchoscopy;cancer therapy;Caring;Catheters;Cellular Phone;checkpoint therapy;Chemoembolization;Clinic;Clinical;clinical center;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Clip;commercialization;Computer software;cone-beam computed tomography;cost effective;cost effectiveness;Data;design;Development;Device or Instrument Development;Devices;Diagnosis;Disease;Dose;Drug Combinations;Drug Delivery Systems;drug discovery;Drug Targeting;Electromagnetics;empowerment;Endoscopy;Engineering;Equipment;experience;falls;Feedback;first-in-human;Fluoroscopy;Focused Ultrasound Therapy;Future;Goals;Goggles;Grant;Heterogeneity;Human Resources;Image;image guided;image guided intervention;image guided therapy;image processing;Imaging Device;imaging modality;immune activation;Immunotherapy;improved;improved outcome;In Vitro;in vivo;instrumentation;Intervention;Interventional radiology;Intramural Research Program;Lasers;Liposomes;Liver;Localized Disease;Lung;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;Medical;Medical Device;Medicine;Metabolic;Methods;microwave electromagnetic radiation;Miniaturization;minimally invasive;Mission;Modality;Modeling;molecular targeted therapies;Monitor;Morphology;multi-component intervention;multidisciplinary;Multimodal Imaging;multimodality;Needles;Normal tissue morphology;novel;novel therapeutics;Oncology;Operating Rooms;Operative Surgical Procedures;Optics;Paper;Patients;personalized therapeutic;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Positioning Attribute;Positron-Emission Tomography;Pre-Clinical Model;precision drugs;Privatization;Procedures;Process;programs;Property;Prostate;Prostate Ablation;prostate biopsy;prototype;radio frequency;Radiofrequency Interstitial Ablation;Radiology Specialty;Rectum;Research;Resolution;Resources;Robotics;Route;Science;side effect;Site;Solid Neoplasm;Standardization;System;Systemic disease;targeted treatment;Techniques;Technology;Temperature;temporal measurement;Testing;Therapeutic;Therapeutic Agents;Therapeutic Embolization;Therapeutic Intervention;Thermal Ablation Therapy;Time;Tissues;tomography;tool;tool development;Toxic effect;Training Programs;Translating;translational potential;Translational Research;treatment planning;tumor;tumor ablation;tumor heterogeneity;ultrasound;United States National Institutes of Health;Urethra;validation studies;Vendor;Vision;Visualization;Work

PROJECT_TITLE: Navigation Tools for Image Guided Minimally invasive Therapies


PROJECT_TERMS: Ablation;Acceleration;adaptive immunity;Algorithms;Animals;Annual Reports;antitumor effect;Back;Benign;Biological;Bladder;Bladder irrigation procedure;Body Temperature;cancer immunotherapy;cancer therapy;Cancer Vaccines;Cell Death;checkpoint inhibition;Chemosensitization;chemotherapy;Child;Clinical;clinical application;clinical practice;clinical translation;Clinical Trials;Clinical Trials Design;cold temperature;comparative;Computer Simulation;Contrast Media;Cryosurgery;Dendritic Cells;Deposition;design;Detection;Development;Device or Instrument Development;Devices;dosimetry;Doxorubicin;Drug Delivery Systems;Drug Regulations;electric field;Electroporation;Emerging Technologies;Endothelial Cells;Engineering;Feedback;Finite Element Analysis;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Gel;Goals;Grant;Heating;Hyperthermia;Image;image guided;image-guided drug delivery;Immune;immune activation;Immune checkpoint inhibitor;immune modulating agents;immune resistance;Immune response;immune stimulant;Immune system;immunogenic;Immunologic Factors;Immunologic Stimulation;Immunomodulators;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Industry;Infrastructure;Injections;Institutional Review Boards;interdisciplinary approach;Investigation;Irrigation;Lasers;liposome vector;Liposomes;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;mathematical model;Mechanics;Medical center;Methods;Mitomycins;Modeling;multimodality;Mus;Muscle;nano;nanoDroplet;nanoparticle;Natural Immunity;neoplasm immunotherapy;new technology;non-invasive imaging;novel;Operative Surgical Procedures;Pathology;Patients;Perfusion;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Phase Transition;Physicians;Physiologic pulse;Polyvinyls;pre-clinical;Pre-Clinical Model;preclinical safety;preclinical study;programs;Prostate;Prostate Cancer therapy;Publishing;radio frequency;Radiosensitization;Research;Research Personnel;Risk;Robotics;Rodent;Safety;Saline;Solid Neoplasm;System;Technology;technology/technique;Temperature;Thermal Ablation Therapy;Thermometry;Time;Tissues;tool;translational potential;Translations;treatment optimization;treatment planning;tumor;Tumor Antigens;Tumor Tissue;Ultrasonic Therapy;ultrasound;ultrasound ablation;United States National Institutes of Health;Universities;Up-Regulation;Urology;Uterine Fibroids;vaccine delivery;Vaccines;Validation;vector;Visualization;Water;Work

PROJECT_TITLE: Image Guided Focused Ultrasound For Drug Delivery and Tissue Ablation


PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Address;Animals;Annual Reports;Antigen Presentation;Antineoplastic Agents;Artificial Intelligence;Atmosphere;Augmented Reality;automated segmentation;Automation;Award;Basic Science;bench to bedside;Biological Markers;Biomedical Engineering;Biopsy;cancer classification;cancer clinical trial;Cancer Patient;cancer therapy;Catheters;CCR;Cellular Phone;checkpoint inhibition;chemotherapy;Clinic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Trials;Clip;Collaborations;collaborative environment;combination cancer therapy;Communities;Computer software;Computers;Cooperative Research and Development Agreement;cost;cost effective;Data;Data Science;Data Scientist;Databases;deep learning;deep learning model;Detection;Development;Devices;Diagnosis;digital pathology;Discipline;Disease;Doctor of Philosophy;Dose;Down-Regulation;Drug Combinations;Drug Delivery Systems;drug discovery;Drug Modelings;Drug Targeting;Ecosystem;Education;education pathway;Electroporation;Emerging Technologies;Energy-Generating Resources;Engineering;Environment;Exposure to;Faculty;Family suidae;Fine needle aspiration biopsy;first-in-human;Fluoroscopy;Focused Ultrasound Therapy;Freezing;Gel;Goals;Goggles;Hepatitis;Human;Image;image guided;Image Guided Biopsy;image guided therapy;image processing;image-guided drug delivery;Imaging Device;imaging modality;imaging scientist;imaging system;Imaging technology;Immune;Immune checkpoint inhibitor;immune modulating agents;immune resistance;immunoregulation;Infusion procedures;Injections;innovation;Intervention;Interventional radiology;Intramural Research Program;Investigation;Kidney;Lasers;Light;Liposomes;Liver;Local Therapy;Localized Malignant Neoplasm;Location;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mechanics;Medical;Medical Oncology;Medicine;Mentors;Methods;Microspheres;microwave electromagnetic radiation;minimally invasive;Modeling;Molecular;Molecular Target;multidisciplinary;Multimodal Imaging;multimodality;nanoparticle;nanoscale;National Institute of Biomedical Imaging and Bioengineering;Needle biopsy procedure;Needles;new technology;novel;Oncologist;Oncology;Operative Surgical Procedures;Organ;Paint;pandemic disease;Pathology;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Physicians;Population;post-COVID-19;pre-clinical;precision drugs;Procedures;prognostication;programs;Prostate;prostate biopsy;Protocols documentation;Radiation;Radiation Oncology;radio frequency;radiologist;Radiology Specialty;Rectum;Reporting;Research;Research Personnel;Resources;Robotics;Saline;Science;Scientist;Screening for cancer;Signal Transduction;small molecule;software development;sound;Standardization;Structure of base of prostate;Students;Surgical Oncology;System;targeted treatment;Techniques;Technology;technology/technique;Testing;Therapeutic Embolization;Thermal Ablation Therapy;Thinness;Time;tool;Training;Training and Education;Translating;translational model;Translational Research;treatment planning;trial planning;tumor;tumor ablation;ultrasound;United States National Institutes of Health;Urethra;urologic;Urologic Oncology;vector;Vision;Visit;Visualization;Voice;web app;Woodchuck

PROJECT_TITLE: Interventional Oncology


PROJECT_TITLE: Imaging of fungal infections


PROJECT_TERMS: 3-Dimensional;3D Print;air filtration;Algorithms;Angiography;Antibodies;Artificial Intelligence;artificial intelligence model;Atelectasis;automated segmentation;Bacterial Pneumonia;Biological Markers;Biopsy;Bridge to Artificial Intelligence;cancer invasiveness;CCR;Cellular Phone;chest computed tomography;Classification;Clinical;clinical imaging;Clinical Trials;Coagulation Process;Collaborations;commercialization;Communicable Diseases;Communication;Computer software;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 patient;Critical Care;crosslink;Custom;Data;data curation;Data Science;Data Set;data sharing;deep learning;deep learning model;design;Detection;Development;Devices;Disease;disease classification;Disease Outbreaks;drug discovery;Epidemiology;Event;Extramural Activities;Family suidae;federated learning;flu;forging;fungal pneumonia;Future;generative artificial intelligence;generative models;Goals;health care settings;Healthcare;Hearing Tests;Home;Image;image guided therapy;image processing;in vivo;Industry;industry partner;Infection;influenza pneumonia;Institution;Institutional Review Boards;Interventional radiology;Investigation;Journals;Knowledge;large datasets;large language model;Learning;Licensing;Link;Liver;Lung;Lung Diseases;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Masks;Measures;Medical;Medical Imaging;Medical Research;medical specialties;Medicine;member;Methodology;Methods;migration;minimally invasive;Modality;Modeling;multidisciplinary;multimodal modeling;multimodality;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;Nature;nonhuman primate;novel;Organ;outcome prediction;Oxygen;Oxygen saturation measurement;pandemic disease;Pathway interactions;Patients;Pattern;Performance;Phenotype;point of care;post-COVID-19;Postoperative Period;Postpartum Period;pre-clinical;Pre-Clinical Model;Prevention;Privacy;Privatization;public-private partnership;Publications;Publishing;Reporting;Research;Research Personnel;Resources;response;Running;screening;Signal Transduction;skills;smartphone application;smartphone based device;Social Distance;social media;Source;Standardization;Starvation;Suggestion;Techniques;Testing;Text;The Cancer Imaging Archive;Thermal Ablation Therapy;Thoracic Radiography;tool;Training;transfer learning;Triage;tumor;United States National Institutes of Health;Vasculitis;Ventilator;Voice;wearable data;wearable device;web site;Weight;Work;working group;X-Ray Computed Tomography

PROJECT_TITLE: Artificial Intelligence in COVID-19, Procedural Medicine and Cancer