NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: RENO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Relevance The University of Nevada, Reno and Truckee Meadows Community College, in partnership with the University of California, Berkeley, The University of California, Davis, the University of Michigan, and Stanford University, propose to increase the number of highly qualified neuroscientists from underrepresented backgrounds. To accomplish this, we will design and implement a rigorous undergraduate neuroscience training program that will prepare talented trainees from diverse backgrounds to enter into and succeed in PhD programs in the neurosciences.

PI_NAMEs: BERRYHILL, MARIAN E;MATHEW, DENNIS ;WEIERICH, MARIANN R (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Acceleration;Admission activity;Advisory Committees;Area;Biology;broadening participation research;California;community college;Critical Thinking;curriculum enhancement;design;Development;Development Plans;disability;disabled students;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Ethnic Origin;experience;Faculty;faculty support;First Generation College Students;follow-up;Funding;Goals;graduate school;Grant;hands on research;higher education;Hispanic-serving Institution;improved;Individual;innovation;Institution;interest;Knowledge;Lead;Leadership;Low income;matriculation;Measurable;Mentors;Methods;Michigan;mid-career faculty;National Institute of Neurological Disorders and Stroke;Neurosciences;Nevada;outreach;professor;Program Effectiveness;programs;Psychology;Qualifying;Race;racial population;Records;recruit;Research;Research Activity;Research Personnel;Research Training;Science;Services;skill acquisition;skills;skills training;socioeconomics;Structure;Students;summer research;Talents;Training;training opportunity;Training Programs;undergraduate education;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Writing

PROJECT_TITLE: BP-ENDURE at the University of Nevada


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Rare Diseases

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project narrative: This proposal will investigate molecular mechanisms of the origin of hypercholesterolemia of nephrotic syndrome and will identify the specific post translational profile of kidney-secreted PCSK9.

PI_NAMEs: CLEMENT, LIONEL CLAUDIUS (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Affinity;Amiloride;Animal Model;Antibodies;Archives;Biopsy;Blood Circulation;Breeding;cell cortex;Cell Line;Cell surface;Cells;Cholesterol;collecting tubule structure;comparison control;Confocal Microscopy;db/db mouse;Detection;Development;Diabetic Nephropathy;Diagnosis;Disease;Duct (organ) structure;epithelial Na+ channel;Family;Focal and Segmental Glomerulosclerosis;gain of function mutation;Gel;Glomerulonephritis;heart disease risk;Hepatic;Human;hypercholesterolemia;hypocholesterolemia;improved;Intestines;Kidney;kidney biopsy;Kidney Diseases;Link;Liver;Longitudinal Studies;Low Density Lipoprotein Receptor;Mass Spectrum Analysis;member;Membranous Glomerulonephritis;migration;Modeling;Molecular;Molecular Chaperones;Mus;Nephrosis;Nephrotic Syndrome;nephrotoxicity;Patient Care;Patient Selection;Patients;Pattern;Pharmaceutical Preparations;Phase;Phosphorylation;Plasma;Play;Post-Translational Protein Processing;prevent;Proprotein Convertases;protein expression;Protein Secretion;Proteins;Proteinuria;Puromycin Aminonucleoside;Rattus;Recombinants;Renal glomerular disease;Rodent;Rodent Model;Role;Sampling;Serine Protease;Serum;sialylation;Sodium;standard care;Subtilisins;Sulfate;Testing;Therapeutic;Tissues;two-dimensional;Urine

PROJECT_TITLE: Kidney PCSK9 in nephrotic syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Vaccine Related

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

ORG_STATE: MI

PHR: Project Narrative Vaccination safety is critical for individual and public health. Currently, vaccine trust is at an all-time low. The proposed ontology-based methods will provide important insights into the underlying mechanism of safety issues. Their development and applications to the VAERS dataset will contribute to public health by enabling earlier identification and prevention of potentially serious safety problems, reassuring the public that vaccines are safe, and recovering the public trust.

PI_NAMEs: ZHAO, LILI  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adverse event;Bayesian Method;Bayesian Modeling;Characteristics;Child;Clinical;Complementary Health;Complex;Computer software;Consensus;Data;data integrity;Data Set;Data Sources;Database Management Systems;Databases;Decision Theory;detection method;Development;Distributed Databases;Early Diagnosis;Early identification;Ensure;Epidemiologist;Evaluation;experience;Face;grandparent;graph theory;Health Personnel;Healthcare;improved;Individual;Informatics;Injury;insight;Interdisciplinary Study;Knowledge;Link;Manufacturer;Medical Dictionaries;medication safety;Methodology;Methods;Mining;Modeling;Modernization;Monitor;Ontology;Parents;Patients;Persons;Pharmacologic Substance;Population Surveillance;Predictive Value;Prevention;Public Health;public trust;Reporting;Research;Research Personnel;Resources;response;Running;Safety;Series;Serious Adverse Event;Signal Transduction;Site;skills;Structure;Surveillance Program;System;Time;tool;Trust;Vaccinated;Vaccination;vaccine adverse event;vaccine evaluation;vaccine safety;Vaccines;Validation;Visualization

PROJECT_TITLE: Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE All living cells must synthesize and maintain proteins to carry out biological functions, but microorganisms frequently face environments that lack the nutrients to do so – both in external environments and during infection of hosts. How do microbes manage to continue producing and maintaining proteins when nutritional resources are scarce? Our research answers this question by examining the critical role of protein-helping molecules, known as chaperones, in enabling pathogenic bacteria to adjust key cellular processes and survive even while starving for essential molecules.

PI_NAMEs: CHAN, CARISSA  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affinity;Anti-Bacterial Agents;Bacteria;Bacterial Drug Resistance;Bacterial Infections;Binding;Biochemical;biological adaptation to stress;Biological Process;burden of illness;Cell Physiology;Cells;Cytoplasm;Dependence;deprivation;Disease;Divalent Cations;Environment;Equilibrium;examination questions;experience;Face;falls;Gene Expression;Genes;Growth;Guanosine Triphosphate;Health;Human;human pathogen;Immune;improved;In Vitro;in vivo;Infection;Life;Macrophage;Maintenance;Mediating;Microbe;microbial;microorganism;Molecular;Molecular Chaperones;Nature;novel;Nucleotides;Nutrient;Nutritional;Organism;pathogen;pathogenic bacteria;pathogenic microbe;Pathway interactions;Phenotype;Physiological;polypeptide;Process;Proliferating;protein aggregation;Protein Biosynthesis;protein folding;Proteins;Proteomics;proteostasis;Repression;Research;Resources;response;Ribosomes;Role;Salmonella typhimurium;Specific qualifier value;Starvation;stem;Stress;System;Testing;Tissues;Translations;tripolyphosphate;Virulence;Work

PROJECT_TITLE: How Molecular Chaperones Promote Pathogen Survival During Starvation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: MEMPHIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The proposed project will develop and conduct a randomized clinical trial for weight loss, using Health IT – EHR patient portal in underserved populations (racial / ethnic minority populations, lower socioeconomic populations, rural populations). The results of the proposed project will help inform patients, healthcare providers, and public- and private-sector health plans on how to treat obesity in underserved populations in primary care settings using the Health IT - EHR patient portal which may prevent cancer.

PI_NAMEs: JOHNSON, KAREN C (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Address;Adult;adult obesity;Affect;Area;behavior change;Behavior Therapy;Behavioral;Body Weight Changes;Body Weight decreased;cancer risk;cancer type;clinical practice;Clinical Practice Guideline;Clinical Trials;Collaborations;Communities;comparison group;comparison intervention;cost effective;Diabetes Mellitus;Diet;Disease;Effectiveness;Electronic Health Record;Enrollment;ethnic minority;ethnic minority population;formative assessment;Funding;Goals;group intervention;Group Practice;Guidelines;Health;health care availability;health information technology;Health Personnel;health plan;Health Sciences;Healthcare Systems;healthy lifestyle;high risk;Incidence;innovation;Intervention;intervention refinement;Intervention Studies;lifestyle intervention;Low income;low socioeconomic status;Malignant Neoplasms;Managed Care;Medical;Methodist Church;Methods;Minority Groups;minority health;minority health disparity;Modeling;Obesity;Obesity associated cancer;obesity management;obesity risk;obesity treatment;Outcome;Overweight;Participant;patient health information;patient portal;Patients;Persons;Physical activity;Physicians;Population;Population Group;prevent;primary care setting;primary outcome;Private Sector;Protocols documentation;Public Sector;racial minority;racial minority population;Randomized;randomized, clinical trials;Recommendation;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Risk;Risk Factors;Risk Reduction;rural area;Rural Population;rural setting;Site;social;social health determinants;socioeconomics;success;Support System;System;Target Populations;Technology;technology intervention;Telephone;Tennessee;Testing;Time;tool;Touch sensation;Training;Translating;Underserved Population;United States;United States National Institutes of Health;Universities;uptake;urban area;urban setting;Weight Gain;weight loss intervention;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: Managing Obesity by Leveraging Health Information Technology to Lower Cancer Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(56)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Digestive Diseases;Health Services;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Microbiome;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the most common surgery for refractory ulcerative colitis and ulcerative colitis-related dysplasia, multiple complications can occur. Short and long-term complications include inflammatory conditions of the pouch such as acute and chronic pouchitis and Crohn’s-like disease of the pouch, each of which can require new medical treatments after surgery and can significantly impact the quality of life of individual patients. This mentored patient-oriented research career development project will generate evidence about the comparative effectiveness of therapies for the treatment of these inflammatory conditions of the pouch, will develop new IPAA-specific patient-reported assessments of pouch symptoms and quality of life, and will utilize precision medicine techniques including machine learning to identify patients at high-risk for developing chronic pouchitis.

PI_NAMEs: BARNES, EDWARD  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Address;Affect;Anastomosis - action;Anti-Tumor Necrosis Factor Therapy;Anus;Area;Award;Big Data;Biological Response Modifier Therapy;candidate selection;career;career development;Chronic;Clinical;clinical care;Clinical Data;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;cognitive interview;Colectomy;Colitis;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;Counseling;Crohn's disease;Crowding;Curative Surgery;Data;design;Development;Development Plans;Diagnosis;Disease;Dysplasia;Educational workshop;effectiveness research;effectiveness study;Ensure;Environment;Epidemiology;experience;Faculty;fecal microbiome;Foundations;Frequencies;Funding;Future;gastrointestinal;Goals;high risk;higher education;Ileal Reservoirs;improved;indexing;individual patient;Inflammatory;Inflammatory Bowel Diseases;Institution;instrument;interest;K-Series Research Career Programs;Knowledge;Laboratories;Machine Learning;machine learning method;Medical;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;microbiota;Modeling;Multiomic Data;North Carolina;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Outcome Assessment;outcome prediction;Patient Care;patient oriented research;Patient Outcomes Assessments;Patients;Peer Review;Population;Positioning Attribute;Pouchitis;precision medicine;Prediction of Response to Therapy;predictive signature;Prevention strategy;Privatization;Productivity;prospective;Prospective cohort;Qualitative Research;Quality of life;Refractory;Registries;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;response;Restorative Proctocolectomy;Risk;Risk Factors;Scientist;skills;Structure;Symptom Burden;Symptoms;Techniques;Time;TNF gene;tool;Training;Translational Research;Treatment Protocols;treatment strategy;Ulcerative Colitis;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative Colitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Aging;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE: This proposal is designed to uncover the role of neutrophils in the decline in vaccine efficacy against Streptococcus pneumoniae with age and identify which extracellular adenosine signaling pathways that boost protection in the elderly.

PI_NAMEs: SIMMONS, SHAUNNA  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Academia;Adenosine;Adenosine A1 Receptor;Adult;Affect;Age;age related;age related changes;age related decline;aged;Aging;Anti-Bacterial Agents;Antibacterial Response;Antibodies;antimicrobial;Bacteria;bacterial community;bactericide;booster vaccine;career;cell injury;Cell surface;Cells;Cellular biology;Cessation of life;community acquired pneumonia;Complement;Complement Receptor;Cytoplasmic Granules;Data;Defect;Deposition;design;Elderly;Environment;Exposure to;extracellular;Fc Receptor;Future;Goals;Gram-Positive Bacteria;Host Defense;Host resistance;Human;human old age (65+);Immune;immune function;Immune response;Immune Sera;immune system function;Immunize;Immunology;immunosenescence;Impairment;improved;Infection;Innate Immune System;Knowledge;MAP Kinase Gene;MAPK3 gene;Mediating;medical schools;Mentors;Microscopy;Mus;neutrophil;old mice;Opsonin;pathogen;Pathway interactions;Phagocytosis;Phagosomes;Pneumococcal conjugate vaccine;Pneumococcal Infections;Pneumococcal vaccine;Predisposition;Prevnar;Production;Purinergic P1 Receptors;Qualifying;receptor;Receptor Signaling;recruit;Research;Research Training;Resistance;Resources;response;Role;Science;Signal Pathway;Signal Transduction;Streptococcus pneumoniae;Surface;Technical Expertise;Techniques;Testing;therapeutic target;Time;Training;transcriptome sequencing;Universities;uptake;Vaccinated;Vaccination;vaccine efficacy;Vaccines;Vulnerable Populations;Work

PROJECT_TITLE: The role of A1 adenosine receptor signaling in the decline of S. pneumoniae killing by neutrophils in vaccinated aged hosts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative  The proposed research seeks to improve the safety and efficacy of implantable cardiovascular devices by establishing an autologous endothelium on the blood-contacting surface. This will minimize the risks of thrombosis and embolism while eliminating the need for anticoagulation therapy and the need for autologous vessel harvest during coronary bypass surgery. The proposed approach represents a novel combination of regenerative engineering and molecular modulation that may have broad applications throughout medicine.

PI_NAMEs: TEFFT, BRANDON J (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Address;adverse outcome;Animal Model;Anticoagulation;Area;Autologous;Biocompatible Materials;Biological;biomaterial compatibility;Blood;Blood flow;Bypass;carcinoembryonic antigen-related cell adhesion molecules;Cardiovascular Diseases;Cardiovascular system;Cell Adhesion;cell behavior;Cell Physiology;Cells;Circulation;Clinical;clinically relevant;Coronary;Coronary Artery Bypass;Coronary heart disease;cost;CRISPR/Cas technology;Data;design;Development;Devices;Diameter;Embolism;Endothelial Cells;Endothelium;Engineering;Environment;Exposure to;Family suidae;Gene Activation;Gene Expression Profile;Generations;Genes;Goals;Harvest;Health;Heart Diseases;Heart Valves;hemocompatibility;hemodynamics;Hyperplasia;Implant;implantable device;implantation;improved;Individual;Inflammation;Inflammatory Response;insight;knock-down;Legal patent;Life;Liquid substance;Maintenance;Mediating;Medicine;Mission;Molecular;Molecular Target;Morbidity - disease rate;nanoscale;National Heart, Lung, and Blood Institute;novel;Operative Surgical Procedures;Outcome;overexpression;patient safety;Patients;Performance;Phenotype;Physiological;Population;Positioning Attribute;Pre-Clinical Model;Productivity;rational design;Regenerative engineering;Regenerative Medicine;Regulation;Research;Risk;risk minimization;Safety;shear stress;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Small Interfering RNA;Stents;Surface;Testing;Thrombosis;Tissue Engineering;TNF gene;transcriptome;transcriptome sequencing;transcriptomics;Vascular Diseases;Vascular Graft;Veins

PROJECT_TITLE: Transcriptomics of adherent endothelial cells for improved endothelialization of small-diameter vascular grafts

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE While being critical for protection from respiratory viral infection, lung resident memory T cells (Trm) wane with time; though the cause of this waning remains unclear. Our lab and others have demonstrated that this waning strongly correlates with the loss of heterosubtypic immunity to influenza A virus (IAV), indicating a critical importance for a more detailed understanding of Trm biology. The proposed study dissects the cause of IAV- specific lung Trm waning through functional, transcriptomic, and metabolic studies of T cell biology and defines vaccination strategies to re-invigorate this critical population of cells through innovative and clinically relevant mRNA-based vaccine platforms.

PI_NAMEs: HASSERT, MARIAH A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Antigen-Presenting Cells;Antigens;Benchmarking;Biology;CD8-Positive T-Lymphocytes;Cell Maintenance;Cell Separation;cell type;Cells;Cellular biology;Cessation of life;clinically relevant;cross immunity;cross reactivity;cytokine;design;Development;differential expression;Epitopes;Exposure to;fatty acid metabolism;Formulation;Generations;Genes;Goals;Health;Hemagglutinin;Hospitalization;Human;Humoral Immunities;Immunity;Immunization;Immunologics;Inactivated Vaccines;Infection;Influenza;Influenza A virus;influenza virus vaccine;innovation;intestinal epithelium;Intramuscular;Intrinsic factor;Knowledge;lipid nanoparticle;Longevity;Lung;Maintenance;Mediating;Memory;Messenger RNA;Metabolic;metabolic abnormality assessment;migration;Molecular;mouse model;Neuraminidase;neutralizing antibody;novel;pandemic influenza;pandemic potential;pathogen;pathogenic virus;Peripheral;Play;Population;Public Health;rational design;Recurrence;respiratory virus;RNA vaccine;Role;Route;seasonal influenza;Seasons;Skin;Spleen;Structure of parenchyma of lung;success;Surface Antigens;T memory cell;T-Lymphocyte;Testing;Time;tissue resident memory T cell;Tissues;Transcend;transcriptomics;Transforming Growth Factor beta;universal influenza vaccine;Vaccination;vaccination strategy;vaccine access;vaccine platform;Vaccines;Viral;Viral Respiratory Tract Infection

PROJECT_TITLE: Antiviral lung resident memory T cell maintenance and reinvigoration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Streptococcus pyogenes causes many diseases and is a leader of infectious morbidity and mortality responsible for >500,000 annual deaths. This project how one of its proteases regulates bacterial virulence mechanisms that lead to toxic shock syndrome and invasive infections like necrotizing fasciitis. Advancing our understanding of this process will give new therapeutic strategies to treat antibiotic-refectory severe disease.

PI_NAMEs: LAROCK, CHRISTOPHER N (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute;Acute Pharyngitis;Agonist;Antibiotics;Antimicrobial Resistance;Automobile Driving;Bacteremia;Bacteria;Binding;Biochemical;biochemical tools;capsule;cathelicidin antimicrobial peptide;Cell surface;Cell Surface Proteins;Cell Wall;Cessation of life;Childhood;Coronavirus;cytokine;Data;Detection;Development;Disease;Environment;Event;Feedback;Gene Expression Regulation;Genetic;Glomerulonephritis;Goals;Homeostasis;Host Defense;Human;human pathogen;Immune;Immune System Diseases;Impetigo;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Integration Host Factors;Interleukin-1 beta;Lead;Link;Mediating;Microbe;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;multiple myeloma M Protein;mutant;National Institute of Allergy and Infectious Disease;Necrotizing fasciitis;neutrophil;novel;novel therapeutic intervention;pathogen;Pathogenesis;Pathologic;Pathology;Peptide Hydrolases;Peptides;Pharyngeal structure;Pharyngitis;Population;prevent;Prevention;Process;Production;prophylactic;protein function;Proteins;Proteolysis;Public Health;Regulation of Proteolysis;Repression;Research;Resistance;response;Rheumatic Fever;Rheumatic Heart Disease;Role;Scarlet Fever;Signal Transduction;Site;Streptococcus;Streptococcus pyogenes;Sum;Surface;System;Therapeutic;therapeutic target;therapeutically effective;Time;tool;Toxic Shock Syndrome;Vaccines;Virulence;Virulence Factors

PROJECT_TITLE: Proteolytic regulation of the Streptococcus pyogenes cell surface

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE This work seeks to understand the molecular mechanisms of retinal photoreceptor protein compartmentalization. Retinal degeneration and blindness may be caused by improper delivery of proteins to specialized regions within photoreceptors, the light detecting cells in our eyes. Understanding the mechanisms that control photoreceptor construction, and what goes wrong with this process in blinding diseases, will help find new therapies to extend or restore vision.

PI_NAMEs: CALVERT, PETER DEANE (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;analytical ultracentrifugation;Apical;arrestin 1;Arrestins;Automobile Driving;Biochemical;Biological;Biophysical Process;biophysical properties;Blindness;Cells;Charge;cilium biogenesis;Cone;Cytoplasm;Darkness;Defect;design;Disease;driving force;Dyes;electric field;Electrostatics;Exclusion;Eye;Feedback;Fluorescence;Fluorescence Anisotropy;fluorescence imaging;Fluorescence Microscopy;Functional disorder;Functional Imaging;Funding;gene-editing approach;Goals;Homo;Hydrophobicity;imaging approach;Imaging Device;In Vitro;in vivo;insight;Knowledge;Light;Lipid Binding;Lipids;Location;Maps;Measures;Membrane;Membrane Proteins;Microscopy;Modification;Molecular;Molecular Chaperones;Neurons;novel;novel therapeutics;Photons;photoreceptor degeneration;Photoreceptors;Phototransduction;physical separation;Preparation;Process;Property;protein distribution;protein folding;protein transport;Proteins;Reporting;Resolution;response;Retina;Retinal Degeneration;Retinal Photoreceptors;retinal rods;Rod;Role;segregation;sight restoration;Signal Transduction;Signal Transduction Pathway;Slice;Surface;Synapses;Time;trafficking;Transgenic Organisms;transmission process;Vertebrate Photoreceptors;Vision;Visual;visual dysfunction;Visual impairment;voltage;Work;Xenopus

PROJECT_TITLE: Mechanisms of photoreceptor protein transport and compartmentalization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(02)M]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative A central goal of our research program is to develop new platforms for the late-stage functionalization of small molecules and biomolecules. In recent years, these efforts have focused on the application of photoredox catalysis as a uniquely enabling paradigm in synthetic chemistry. Our aim is to harness this visible light-driven catalytic platform to (1) enable facile and efficient access to biologically active compounds of high interest and (2) expand the current toolbox for biological studies at the molecular level.

PI_NAMEs: MACMILLAN, DAVID W (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Photoredox Catalysis Applications in Organometallics and Chemical Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE. T follicular helper cells (Tfh) are required to generate long-lasting antibody responses, which confer long-term protection to respiratory viruses. Thus, understanding how Tfh cell responses are created and maintained will allow us to design more efficient vaccines to pathogens such influenza virus, which is responsible for an average of 35,000 deaths annually in the US and has the potential of trigger world-wide pandemics. This proposal will define the mechanisms implicated in the generation of “high-quality” Tfh cell responses.

PI_NAMEs: RANDALL, TROY D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Achievement;Adjuvant;Affect;Agreement;Antibodies;Antibody Response;Antibody-mediated protection;B cell differentiation;B-Lymphocytes;CD4 Positive T Lymphocytes;Cell Communication;Cells;Cessation of life;ChIP-seq;Collaborations;Communicable Diseases;cytokine;Data;design;Development;disability;Environment;Equilibrium;experimental study;Generations;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;Home;Homeostasis;human pathogen;Immune response;Immunity;Impairment;improved;Individual;Infection;Influenza;influenza infection;influenzavirus;Interferon Type II;Interleukin-12;Interleukin-4;Interleukin-6;Knowledge;Lung;Maintenance;Mediating;Memory;Memory B-Lymphocyte;Molecular;Mutate;Outcome;Output;pandemic disease;pathogen;plasma cell differentiation;Plasma Cells;Play;Population;prevent;Production;programs;Property;prophylactic;Public Health;Reaction;Recording of previous events;respiratory virus;response;Role;Scheme;Shapes;Signal Transduction;single-cell RNA sequencing;STAT1 gene;STAT6 gene;Structure of germinal center of lymph node;Testing;Time;transcriptome sequencing;Vaccination;vaccination strategy;vaccine efficacy;Vaccines

PROJECT_TITLE: Functional Implications of Tfh Cell Heterogeneity after Infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The diagnosis of HCC and assessment of its response to treatment rely primarily on imaging biomarkers which have replaced tissue-based measures. Recent studies demonstrate significant limitations of standard-of-care imaging paradigms for: (i) distinguishing HCCs from other tumors commonly observed in the liver, (ii) informing on the molecular and cellular biology required to facilitate treatment stratification and (iii) assessing treatment response. The development of the functional imaging strategies required to address these deficiencies has been limited by the absence of methodologies that can tailor imaging probe selection to the relevant HCC biology as well as a dearth of representative animal models. Using genome editing and metabolomics, our laboratory has demonstrated fundamental enzymatic dependencies of HCC cells to be promising imaging targets for diagnosis and treatment response assessment using Dynamic Nuclear Polarization 13Carbon Magnetic Resonance Spectroscopic Imaging, a novel and emerging imaging technology. The proposed project will build on this prior work to assess the accuracy of this technology for diagnosing and characterizing HCC and for treatment response assessment using unique translational animal models developed in our laboratory.

PI_NAMEs: GADE, TERENCE P (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Achievement;Address;aerobic glycolysis;Aftercare;Alanine;anatomic imaging;Animal Model;Arterial Embolization;Ascorbic Acid;BAY 54-9085;Biology;cancer cell;Cancer Etiology;cancer imaging;Carbon;Cell Survival;Clinic;clinical application;clinical imaging;Clinical Trials;Common Neoplasm;contrast enhanced;Data;Dehydroascorbic Acid;Dependence;Detection;detection sensitivity;Development;Diagnosis;diagnostic accuracy;Disease;Functional Imaging;genome editing;Glucose;Image;imaging biomarker;imaging probe;Imaging technology;improved;in vivo;Inferior;Ischemia;Laboratories;Lactate Dehydrogenase;Life Expectancy;Liver;liver cancer model;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Epithelial Cell;Malignant Neoplasms;Measurement;Measures;Metabolic;metabolic imaging;Metabolism;metabolomics;Methodology;Methods;Molecular and Cellular Biology;molecular imaging;mortality;NADP;novel;Nuclear;Oxidation-Reduction;Oxidoreductase;Pathologic;patient prognosis;Patients;Physiologic pulse;Positron-Emission Tomography;Primary carcinoma of the liver cells;Prognosis;Pyruvate;Pyruvate Metabolism Pathway;Recurrence;Reproducibility;Residual Neoplasm;Residual state;Resolution;response;Selection for Treatments;Sensitivity and Specificity;Shunt Device;Signal Transduction;Specificity;spectroscopic imaging;standard of care;Stress;targeted imaging;targeted treatment;Technology;Testing;Therapeutic;Time;Tissues;Translating;treatment response;treatment stratification;tumor;Tumor Burden;tumorigenesis;United States;uptake;Work

PROJECT_TITLE: Dynamic Nuclear Polarization MR Spectroscopic Imaging for Diagnosis and Treatment Response Assessment in Hepatocellular Carcinoma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Group 2 innate lymphoid cells (ILC2) and eosinophils are both innate immune cells. This study is proposed to test a direct role of ILC2 in post-MI (myocardial infarction) cardiac function by regulating the development and function of eosinophils.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute myocardial infarction;Adipocytes;Adipose tissue;Adoptive Transfer;Allergic;Apoptosis;arginase;atherogenesis;Basic Science;Blood;Blood Circulation;Bone Marrow;Bone Marrow Transplantation;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cause of Death;Cell Death;Cell Physiology;Cells;Clinical Research;conditional knockout;coronary fibrosis;Coronary heart disease;cytokine;Cytoprotection;Dendritic Cells;Development;Diphtheria Toxin;eosinophil;Eosinophil cationic protein;Event;Female;Fibroblasts;Fibrosis;Granulocyte-Macrophage Colony-Stimulating Factor;Heart;Heart Block;Heart failure;heart function;Heart Injuries;Human;IL2 gene;IL3 Gene;IL4 gene;IL5 gene;Immune;improved;In Vitro;Inflammation;Interleukin-10;Interleukin-13;ischemic injury;Lipids;Lymphocyte;Lymphoid Cell;male;Mediating;Mediator;migration;Molecular;mortality;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Obesity;obesity development;Orthologous Gene;Parasitic infection;Patients;Play;Population;Prevalence;programmed cell death protein 1;Protein Biosynthesis;protein expression;Recombinants;recruit;Regulatory T-Lymphocyte;Reporting;Residual state;response;Risk;Risk Factors;Role;Sex Differences;Site;success;Testing;Wild Type Mouse

PROJECT_TITLE: Role of group 2 innate lymphoid cells in myocardial infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative  The goal of this research is to determine the operating modes of sensorimotor circuits during the detection and processing of sensory stimuli, and how these circuits mediate appropriate orienting responses to novel or meaningful stimuli. Such basic knowledge is vital to understand how the brain mediates normal behavior and has direct relevance to many neurological and psychiatric disorders, such as sensory neglect syndromes, learning disabilities, Parkinson’s disorders, and others.

PI_NAMEs: CASTRO-ALAMANCOS, MANUEL A (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acute;Address;Animals;Behavior;Behavioral;Brain;brain tissue;Cre driver;designer receptors exclusively activated by designer drugs;Detection;Disease;Electrophysiology (science);Environment;Exploratory Behavior;external ear auricle;Eye;Fingers;Goals;habituation;Head;Histology;information processing;Knowledge;Learning Disabilities;Limb structure;Mediating;Mental disorders;Methods;Motor;Movement;Nervous System Disorder;neural;neural circuit;Neurons;novel;operation;optogenetics;Parkinson Disease;Pathway interactions;Pharmacology;Population;Positioning Attribute;Process;Research;response;Rodent;Role;sensor;Sensory;Sensory Neglects;sensory stimulus;Slice;Stimulus;Syndrome;Testing;Vibrissae;vigilance

PROJECT_TITLE: Sensory pathways for stimulus detection during behavior


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative (Overall, Sil and Dandekar) The proposed studies will use a broad range of approaches to understand the virulence mechanisms utilized by Coccidioides and the varied host response to this ubiquitous fungal infection. These studies will lead to the characterization of molecules and pathways at the Coccidioides host-pathogen interface, and have broad implications for closing diagnostic and therapeutic gaps for Valley Fever.

PI_NAMEs: DANDEKAR, SATYA ;SIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acute;anti-fungal agents;Antibodies;Antigens;Automobile Driving;Behavior;Biological Markers;Biological Products;Biology;Blood;California;cell type;Cells;Cerebrospinal Fluid;Chronic;chronic infection;Clinical;Coccidioides;Coccidioidomycosis;Collaborations;Communication;Cytometry;Data Analyses;data integration;Data Set;desert fever;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Drug Screening;eosinophil;experimental study;Foundations;Fungal Antigens;fungus;Future;Genetic Transcription;Goals;Growth;Human;Immune;Immune response;Immune system;Immune System Diseases;immunological diversity;Infection;laboratory experiment;Learning;Lung nodule;Macrophage;Medical;Meningitis;Metabolic;metabolomics;microbial;Modeling;Molecular;Molecular Profiling;Molecular Target;mouse model;multidisciplinary;Mus;mutant;Mycoses;Nature;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;permissiveness;Pharmaceutical Preparations;Research;response;Role;Sampling;single-cell RNA sequencing;small molecule;sound;Source;Surveys;T cell response;technological innovation;Technology;Testing;The science of Mycology;Therapeutic;therapeutic development;Time;Transcript;transcriptome;transcriptomics;Treatment Failure;Virulence;Virulence Factors

PROJECT_TITLE: Molecules and Pathways at the Coccidioides Host-Pathogen Interface


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: SIL, ANITA  (contact)

PROJECT_TERMS: Area;Arizona;Basic Science;Biological Models;Biology;Chronic;Clinical;Clinical Investigator;Coccidioides;Coccidioidomycosis;Collaborations;combat;Communicable Diseases;Core Facility;Cytometry;Data;Development;Diagnostic;Disease Progression;Elements;Ensure;Feedback;Fostering;Funding;fungus;Genetic;Goals;Immune response;Immunology;Infection;infectious meningitis;insight;Leadership;meetings;member;Meningitis;Mentors;Metabolic;Metagenomics;Microbiology;Molecular Biology;Mucosal Immunity;mutant;Neurologist;next generation sequencing;novel;Occupational activity of managing finances;Participant;pathogen;Pathogenesis;Pathway interactions;Patient Care;Patients;Persons;Physicians;Productivity;programs;recruit;Research;Research Personnel;Sampling;Scientist;Seasons;single-cell RNA sequencing;Subgroup;success;synergism;Technology;Teleconferences;The science of Mycology;Therapeutic;transcriptomics;Universities;Vaccine Design;Virulence

PROJECT_TITLE: Administrative core


ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE: CLC transporters control molecular processes indispensable to normal function of many tissues in diverse organisms including humans. This project aims at characterizing the molecular mechanism of these transport proteins, thereby providing a framework to understand CLC malfunction in several pathophysiological conditions such as neurological disorders, hypertension, and diseases of kidney, muscle, and bone.

PI_NAMEs: MADUKE, MERRITT C (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Active Biological Transport;Affect;Anions;antiporter;Behavior;Binding;Biological Assay;biophysical techniques;bone;Carrier Proteins;Cations;Chloride Channels;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Crystallography;Data;design;Electrons;Event;extracellular;Family;Homologous Gene;Human;Hydration status;Hypertension;Ion Channel;Ion Transport;Ions;Kidney Diseases;Kinetics;Knowledge;Measurement;Methodology;Modeling;Molecular;Molecular Conformation;Monitor;Movement;Muscle;mutant;Mutation;Nervous System Disorder;Organism;Pathway interactions;Play;Process;Protein Conformation;Protein Region;Proteins;Protons;public health relevance;Pump;Resolution;Role;Secondary to;Side;simulation;Spectrum Analysis;Structure;Testing;Tissues;Variant;Water;water channel

PROJECT_TITLE: Mechanisms of CLC Transporters and Channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: BARKER, BRIDGET MARIE (contact)

PROJECT_TERMS: Affect;Algorithms;Antigens;Applied Genetics;Bioinformatics;Biological Assay;Candidate Disease Gene;candidate identification;Cell Culture Techniques;Cells;Centers for Disease Control and Prevention (U.S.);Clustered Regularly Interspaced Short Palindromic Repeats;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Coculture Techniques;Complex;cost;CRISPR/Cas technology;Data;Data Analyses;Defect;desert fever;Development;Diagnostic;Disease;Disease Outcome;Engineering;experience;experimental study;Fungal Drug Resistance;Gene Deletion;gene function;Gene Targeting;Genes;Genetic;genetic approach;Genetic Transcription;genome analysis;genome wide association study;Goals;Human;Immune;improved;In Vitro;in vitro Assay;Incidence;Infection;insight;interest;Label;Laboratories;Lead;Length of Stay;Macrophage;Marketing;Methodology;Modeling;Morphology;mouse model;Mus;mutant;novel;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Pattern;Phase;Phenotype;Plasmids;Play;programs;promoter;Proteins;Reporting;Research;Research Proposals;reverse genetics;Role;Sister;Technology;Testing;Therapeutic;Time;tool;trait;Transcript;vaccine development;Vaccines;Virulence;Virulence Factors;Visualization software;Work

PROJECT_TITLE: CRISPR and Virulence Core


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Aspergillus section Fumigati is a group of closely related species that vary considerably in their pathogenicity; whereas A. fumigatus is a major human pathogen and a few other species are also pathogenic, most species in the section are not pathogenic. To understand the observed variation in pathogenicity, our project will examine multiple biological and chemical traits known to influence pathogenicity in a comprehensive set of Aspergillus section Fumigati species and strains that span the pathogenicity spectrum. The results of our project will yield insights into the evolution of the traits and genetic elements important for Aspergillus pathogenicity and, more generally, into the evolution of fungal virulence.

PI_NAMEs: ROKAS, ANTONIS  (contact)

PROJECT_TERMS: Aspergillosis;Aspergillus;Aspergillus fumigatus;Biological;Body Temperature;Chemicals;Clinical;Code;combat;Death Rate;Disease;DNA;Ecology;emerging pathogen;Engineering;Environment;Evolution;experimental study;fungus;Generations;Genes;Genetic;Genetic Determinism;genetic element;Genetic Transcription;Genetic Variation;Genome;genome-wide;Genomics;Growth;Hospitals;Human;Human body;human disease;human morbidity;human mortality;human pathogen;Hybrids;immunosuppressed;In Situ;In Vitro;in vivo;Infection;innovation;insight;Link;Measures;Medical;model organism;Modeling;mouse model;novel;Nucleic Acid Regulatory Sequences;Organism;overexpression;pathogen;pathogenic fungus;Pathogenicity;Pathway interactions;Phenotype;Phylogeny;Production;Protein Analysis;Resources;response;secondary metabolite;Specificity;stem;Stress;Taxonomy;Testing;The science of Mycology;trait;transcriptomics;Untranslated RNA;Variant;Virulence

PROJECT_TITLE: Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relatives

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

PI_NAMEs: THOMPSON, GEORGE RICHARD (contact)

PROJECT_TERMS: anti-fungal agents;Antigens;base;biobank;Bioinformatics;Biological Assay;biomarker identification;Biometry;biosignature;Blood specimen;California;candidate identification;Caring;Catchment Area;Center for Translational Science Activities;Clinic;Clinical;clinical care;Clinical Data;Clinical Management;Clinical Research;Clinical Sciences;Clinical Trials;Coccidioides;Coccidioidomycosis;Collaborations;Collection;Communicable Diseases;Communities;Computerized Medical Record;Conduct Clinical Trials;Consent;Data;Data Coordinating Center;Data Set;Databases;desert fever;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;diagnostic tool;Disease;Drug Industry;empowerment;Enrollment;Evaluation;exome sequencing;experience;Genomics;Health;Human;Immune;Incidence;Infection;Infrastructure;Internal Medicine;Intervention;Investigation;Laboratories;Lead;Life;Link;Lung infections;Medical History;Metabolic;metabolomics;Molecular;Monitor;Morbidity - disease rate;mortality;novel diagnostics;Outcome;Participant;participant enrollment;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmacy facility;Play;Predisposition;preservation;Procedures;programs;Public Health;Pulmonology;radiological imaging;Reagent;repository;Research;Research Personnel;research study;Research Support;Resources;response;Retrieval;Role;sample collection;Sampling;Serodiagnoses;Serology;Serum;Severity of illness;Source;Technology;Therapeutic;transcriptomics;Translational Research;Treatment outcome;United States National Institutes of Health;Validation;validation studies;Vulnerable Populations;Work

PROJECT_TITLE: Clinical and Diagnostics Core


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Headaches;Migraine;Neurosciences;Pain Research;Pediatric;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Migraine is more prevalent in females and individuals with a family history of migraine however, who will develop migraine is as yet unknown. This study aims to identify the factors which predict migraine onset and the changes preceding or following migraine onset in girls. The results of this study will facilitate the development of early preventive strategies and personalized medicine for migraine.

PI_NAMEs: NAHMAN-AVERBUCH, HADAS  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Adolescence;Adolescent;Age;Amygdaloid structure;Biological Assay;Childhood;chronic pain;chronic painful condition;cingulate cortex;conditioned pain modulation;Control Groups;cost;Data;Development;Diagnosis;Early identification;Exclusion;experience;Family history of;Female;Female Adolescents;follow-up;Frequencies;Functional disorder;functional MRI scan;girls;Headache;Healthcare Systems;High Prevalence;high risk;Hormonal;Hormonal Change;Individual;Injury;Investigation;Measurement;meetings;Menarche;Middle frontal gyrus structure;Migraine;migraine treatment;Modeling;neural;novel;Operative Surgical Procedures;Pain;pain sensitivity;Pain Threshold;Participant;Patients;personalized medicine;precision medicine;Predictive Factor;pressure;Prevalence;Prevention;Prevention strategy;Procedures;Psychophysics;Puberty;recruit;response;Risk;Risk Factors;Sensory;sex;Specialist;Testing;Testosterone;Time;Visit;Women's prevalence

PROJECT_TITLE: Migraine Onset in Adolescent Girls

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Migraine is highly prevalent and debilitating, considered a major public health concern, and its underlying pathobiology is not well understood. We propose to dissect a novel underlying mechanism, involving the production of reactive nitroxidative species, and their downstream alterations to glutamatergic signaling and neuroinflammatory mechanisms, which mediate nociceptive migraine-like responses. We will validate A3AR agonists as a solution for the treatment of migraine, by modulating these underlying molecular mechanisms, addressing this significant socioeconomic problem.

PI_NAMEs: AKERMAN, SIMON  (contact);SALVEMINI, DANIELA

PROJECT_TERMS: Acceleration;Acute;Address;Adenosine A3 Receptor;Adult;Affect;Agonist;Analgesic Overuse Headaches;antagonist;Attenuated;attenuation;Behavioral;behavioral outcome;Biochemical;Biochemical Pathway;Blood Platelets;Cephalic;Chronic;chronic pain management;Clinic;Clinical Research;clinical translation;Clinical Trials;comparison control;Cutaneous;cytokine;Data;Development;Disease;Dose;Electrophysiology (science);Family;Female;genetic approach;glutamatergic signaling;Glutamates;Goals;Headache;Headache Disorders;Hypersensitivity;Inflammasome;Inflammation;Inflammatory;insight;interdisciplinary approach;Interleukin-1;Investigation;Knockout Mice;Link;male;marenostrin;Measures;Mediating;Medical;Migraine;migraine treatment;Modeling;Modification;Molecular;Molecular Target;Monoclonal Antibodies;Neuroglia;neuroinflammation;neuronal excitability;Neurons;Neuropharmacology;neurotransmission;new therapeutic target;Nociception;nociceptive response;non-opioid analgesic;novel;novel therapeutic intervention;novel therapeutics;Opioid;Outcome;Pain;pain model;pain relief;painful neuropathy;Pathway interactions;Patients;Peripheral;Peroxonitrite;Persistent pain;pharmacologic;Pharmacology;Pilot Projects;Population;Post-Translational Protein Processing;Pre-Clinical Model;Preventive;Process;Production;Proteins;Public Health;Publishing;receptor;Receptor Activation;Reporting;response;Rodent;Rodent Model;Role;Safety;Serum;Signal Transduction;socioeconomics;somatosensory;Specificity;Spinal;Structure of trigeminal ganglion;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;Translations;Treatment Efficacy;Trigeminal Nuclei;Trigeminal System;triptans;Work

PROJECT_TITLE: Molecular basis for adenosine A3 receptor agonists in the treatment of migraine

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Valley Fever

PROJECT_TERMS: Acceleration;Affect;Area;Arizona;Biology;California;Candidate Disease Gene;candidate identification;Carbon Dioxide;Cells;Central America;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;density;Development;Diagnostic;Disease;Disease Progression;Dissection;DNA Sequence;drug discovery;drug repurposing;Drug Screening;Event;experience;fungus;gene discovery;gene function;Genes;Genetic;Genome;genome wide association study;genome wide screen;Genomics;Germination;Growth;Growth and Development function;High temperature of physical object;Hospital Costs;Immune;Immunocompetent;Incidence;Incubated;Individual;Infection;Inhalation;Laboratories;Libraries;Lung;Mediating;Methods;Molecular;Mutagenesis;mutant;Nature;new therapeutic target;novel;novel therapeutic intervention;nuclear division;Organism;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Population;Process;Proteomics;Public Health;Publishing;Reproduction spores;Resolution;Role;Rupture;Scientist;Site;small molecule;Soil;Source;South America;System;Temperature;Testing;therapeutic candidate;tool;trait;transcription factor;transcriptomics;Variant;Virulence;virulence gene;Work

PROJECT_TITLE: Virulence gene discovery in Coccidioides


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE. Inflammasomes are protein assemblies inside host cells that detect the presence of microbial pathogens including Gram-negative bacteria to alert the immune response. This proposal focuses on a new group of host immune proteins - the Guanylate Binding Proteins (GBPs) – that tailor the “non-canonical” inflammasome response specifically against Gram-negative bacteria such as Salmonella that are a major cause of food-borne gastroenteritis and blood-borne sepsis in U.S. intensive care units. Our efforts will uncover how GBPs control the “non-canonical” inflammasome that provides a conceptual framework for therapies aimed at treating life- threatening Gram-negative infections and sepsis.

PI_NAMEs: MACMICKING, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Acute;Bacteria;Bacterial Infections;Binding Proteins;Biochemical;Capsid Proteins;Caspase;Cell Death;Cell membrane;Cell Wall;Cells;Chromosomes;Coatomer Protein;Complex;CRISPR/Cas technology;cytokine;Dependence;design;Detection;Engineering;Event;experimental study;Family;Family member;foodborne;gain of function;Gastroenteritis;Gene Cluster;Genes;Genome engineering;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;gram-negative sepsis;Grant;Guanosine Triphosphate Phosphohydrolases;guanylate;Host Defense;Human;human disease;Immune;Immune response;Immune system;Immunity;In Vitro;in vivo;Individual;Infection;Inflammasome;insight;Integration Host Factors;Intensive Care Units;Knockout Mice;Lesion;Life;Lipopolysaccharides;loss of function;Lytic;Macromolecular Complexes;Macrophage;member;Membrane;microbial products;Modeling;Molecular;Mus;mutant;Natural Immunity;Outcome;Output;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathway interactions;Population;prevent;Process;Property;protein complex;Protein Deficiency;Proteins;reconstitution;recruit;response;Role;Salmonella;Salmonella typhimurium;sensor;Sensory;Sepsis;Signal Transduction;Surface;Testing;Therapeutic;Tissues;trafficking;Variant;VDAC1 gene

PROJECT_TITLE: GBPs as new inflammasome regulators during mammalian host defense


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The proposed studies will not only elucidate the fundamental mechanisms that regulate retina cell number, but also provide general insights into how cell number is determined in other organs during animal development and how aberrant regulation of this process could lead to tissue atrophy or hyperplasia. Such insights may facilitate the therapeutic interventions of relevant human diseases, including diseases of the retina.

PI_NAMEs: PAN, DUOJIA  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Actomyosin;Animals;Area;Atrophic;Biochemical;cancer cell;Cell Count;Cell Differentiation process;Cell Nucleus;cell type;Cells;cellular transduction;combinatorial;Communities;Complex;compound eye;Cytoskeleton;Development;Developmental Biology;DNA Binding;Drosophila eye;Drosophila genus;Exclusion;Experimental Models;Eye;Eye Development;Family;Fatty acid glycerol esters;fly;gene repression;Genes;Genetic;Genetic Epistasis;Genetic Screening;Genetic Transcription;Goals;Grant;Growth;histone methyltransferase;human disease;Hyperplasia;in vivo;insight;Laboratories;Link;Mammals;Mediating;Modeling;Molecular;mutant;Mutation;mutation screening;Myosin Type II;Natural Immunity;Neurofibromin 2;novel;Oncoproteins;Organ;Organ Size;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Process;programs;Protein Dephosphorylation;Proteins;receptor;recruit;Regulation;Research;Retina;Retinal Diseases;Role;Signal Transduction;Specific qualifier value;Spectrin;stem cell biology;Testing;Therapeutic Intervention;Tissues;transcription factor;Transcription Repressor;Tumor Suppressor Proteins;Zinc Fingers

PROJECT_TITLE: Control of Cell Number in Developing Retina

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Valley Fever

PROJECT_TERMS: adaptive immune response;Antibodies;Area;Bacteriophages;Biopsy Specimen;Blood;Blood specimen;Bone Marrow;California;Cancer Patient;cell type;Cells;Central Nervous System Diseases;Cerebrospinal Fluid;Chronic;chronic infection;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coccidioides;Coccidioides immitis;Coccidioidomycosis;Collaborations;community acquired pneumonia;Complex;Cytometry;Data;desert fever;Development;Diagnostic;diagnostic biomarker;diagnostic development;Disease;Disease Outcome;Elements;Epitope Mapping;Etiology;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Granulomatous;Human;Immune;Immune response;immunogenic;In Vitro;Infection;infectious meningitis;Infrastructure;insight;interest;Learning;Letters;Libraries;Lung;Lung nodule;Macrophage;Meningitis;microbial;microbial genome;Modeling;Molecular;Molecular Profiling;Mus;mutant;Neurologist;next generation;Nodule;pathogen;pathogenic fungus;Pathology;Pathway interactions;Patients;Peptides;Phage Display;Population;Proteome;Reaction;Research Personnel;Resolution;Resources;response;Sampling;Serology;Serum;single-cell RNA sequencing;Structure of parenchyma of lung;success;targeted treatment;Technology;Testing;Therapeutic;transcriptomics;Tumor Tissue;Vaccine Design;Variant;Virulence

PROJECT_TITLE: Molecular and cellular analysis of host response to Cocci


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Endocrine Disruptors;Genetics;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: WOODS HOLE

ORG_NAME: WOODS HOLE OCEANOGRAPHIC INSTITUTION

PHR: Project Narrative The proposed research investigates the impact of early life exposure to environmental chemicals on the immune cells in the brain. Altered function of the immune cells early in life has been associated with increased risk of development of various neuropsychiatric and neurodegenerative diseases. Using imaging, genetic and behavioral approaches, the results of this research will provide fundmental knowledge about the effects of early life exposure to contaminants on the immune cells in the brain and the potential long-term consequences of neuroinflammation early in life.

PI_NAMEs: ALURU, NEELAKANTESWAR  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adolescent;Adult;adult neurogenesis;Affect;Agonist;Animal Model;Anxiety;Anxiety Disorders;anxiety-like behavior;anxiety-related disorders;Aryl Hydrocarbon Receptor;Behavioral;behavioral phenotyping;Biological Models;Brain;Cell Culture System;Cell Physiology;Cells;Cellular Morphology;Central Nervous System;cognitive process;confocal imaging;Country;Defect;Development;Dioxins;Disease;DNA Methylation;DNA methylation profiling;early life exposure;Embryo;Emotional Stress;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epigenetic Process;experience;Exposure to;Foundations;Functional disorder;Future;Gene Expression;Genetic;Genetic Predisposition to Disease;Genetic Transcription;glial activation;Image;Immune;immune function;Immune response;Immunity;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Knowledge;Learning;Life;Ligands;Macrophage;Measures;Memory;Mental Depression;Mental disorders;Microglia;model organism;Modeling;Molecular;Morbidity - disease rate;Morphology;Nervous System Disorder;neurobehavior;neurobehavioral;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic;Neurons;neuropsychiatric disorder;neuropsychiatry;Pathogenesis;Phagocytes;physiologic stressor;Physiological;Play;Polychlorinated Biphenyls;Predisposition;Pregnancy;prevent;Production;Public Health;Regulation;Research;response;Risk;Risk Factors;RNA methylation;Role;Schizophrenia;Schools;single-cell RNA sequencing;Stress;synaptic pruning;Testing;Time;transcription factor;Transgenic Organisms;United States;Zebrafish

PROJECT_TITLE: Investigating the role of neuroinflammation in environmental exposure-induced anxiety disorders

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Valley Fever

PI_NAMEs: DANDEKAR, SATYA  (contact)

PROJECT_TERMS: Acute;Antibodies;Bacterial Infections;Biological Markers;biosignature;Blood specimen;Body Fluids;Cell Physiology;Cerebrospinal Fluid;Chronic lung disease;Clinical;Clinical assessments;clinical care;Coccidioides;Coccidioidomycosis;cohort;Data;Data Analyses;Databases;desert fever;Development;Diagnostic;Disease;Disease Outcome;Disease Progression;Disease susceptibility;Enrollment;Eosinophilia;Epitope Mapping;experience;Failure;Future;Goals;high risk;Immune;Immune response;Immune System Diseases;Immunity;Immunologics;Impairment;In Vitro;in vivo;Individual;Infection;Integration Host Factors;Interdisciplinary Study;Investigation;Knowledge;Laboratories;lung development;Lung Diseases;Macrophage;Maps;Measurement;Measures;Meningitis;Metabolic;Metabolic dysfunction;Metabolic Pathway;metabolomics;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;mutant;Newly Diagnosed;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Persons;process evaluation;prognostic;Prospective Studies;Pulmonary Pathology;repository;research clinical testing;Resources;Role;sample collection;Sampling;Severities;Severity of illness;Stream;Symptoms;T cell response;targeted treatment;Therapeutic;therapeutic target;transcriptomics;Treatment Failure;Virus Diseases

PROJECT_TITLE: Immune and metabolic correlates of Coccidioides disease spectrum and outcomes


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative Paraganglioma and pheochromocytoma are rare cancers that can run in families and can spread and kill patients. We are studying the unusual errors in gene recipes that cause these tumors. The current project uses a method to identify additional gene recipes required only by the tumor cells as clues to possible new therapies.

PI_NAMEs: MAHER, LOUIS JAMES (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Address;Allografting;Alzheimer's Disease;Automobile Driving;Bar Codes;Breast Cancer Cell;Candidate Disease Gene;candidate identification;cell growth;Cell Line;Cell model;cell type;Cells;Chromaffin Cells;Citric Acid Cycle;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR screen;Data Analyses;deep sequencing;Defect;demethylation;Diabetes Mellitus;Dioxygenases;Disease;DNA;Electron Transport;Enzymes;ESR1 gene;Estrogen Receptor 2;experimental study;Family;Gastrointestinal Stromal Tumors;Gene Expression;gene repression;Gene Targeting;Genes;genome-wide;Genomic DNA;Growth;Guide RNA;Heart Diseases;Hereditary Paraganglioma;Histones;hormone therapy;Hypoxia;Inherited;insight;knock-down;Lethal Genes;Link;Malignant Neoplasms;Measures;Metabolic;Methods;Mitochondria;Modeling;Molecular;molecular pathology;Monitor;Mus;Mutation;neoplastic cell;neuroendocrine cancer;novel;novel therapeutics;Paraganglioma;Pathologic;Pathway interactions;Patients;Pheochromocytoma;Positioning Attribute;Pre-Clinical Model;promoter;rare cancer;Recipe;Renal Carcinoma;Resistance;RNA library;Running;screening;Signal Transduction;Succinate Dehydrogenase;Succinates;Synthetic Genes;targeted treatment;Testing;Therapeutic;Time;Tissues;Transcription Repressor;tumor;Tumor Suppressor Genes;tumorigenesis;Validation;Work

PROJECT_TITLE: Genome-wide synthetic lethal screening for vulnerabilities in a cell model of succinate dehydrogenase-loss paraganglioma


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Despite collaborative national trials of multimodal therapy and chemotherapy intensification, the outcome for patients with advanced stage rhabdomyosarcoma (RMS) has not improved in two decades. We have identified a cancer-driving factor, to which RMS cells are addicted. In this application, we propose the systematic investigation of targeting this factor as a novel approach against RMS.

PI_NAMEs: LI, HUI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 20 year old;absorption;Adolescent and Young Adult;Alveolar;Alveolar Rhabdomyosarcoma;Animals;Automobile Driving;Avil;Biological Assay;Biological Availability;Biological Markers;Breeding;Cell Death;Cell Line;cell motility;Cell Proliferation;Cells;chemotherapy;Childhood;Collection;Combined Modality Therapy;Cytoskeleton;Data;Development;Disease;Drug Kinetics;efficacy evaluation;efficacy testing;F-Actin;Fibroblasts;follow-up;FOXM1 gene;Gene Fusion;Gene Knock-Out Model;Gene Silencing;Genes;Genetically Engineered Mouse;Goals;Histology;Housekeeping Gene;Housing;In Vitro;in vitro testing;in vivo;inhibitor;Injections;Intravenous;Investigation;Knockout Mice;Knowledge;Lead;Malignant Childhood Neoplasm;Malignant Neoplasms;Mesenchymal Stem Cells;Metabolism;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Development;mutant;nanomolar;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenes;Oncogenic;Oral;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Preparations;pharmacodynamic biomarker;Phenocopy;Planet Mars;Predisposition;Prognosis;Property;Proteins;Rhabdomyosarcoma;RNA;RNA Interference;Role;Safety;Sarcoma;screening;Series;small hairpin RNA;small molecule;small molecule inhibitor;soft tissue;Solubility;targeted treatment;Testing;Tetanus Helper Peptide;therapeutic biomarker;therapeutic target;therapeutically effective;Tissues;transcriptome;Transgenic Mice;Transgenic Organisms;tumorigenesis;tumorigenic;virtual;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting AVIL, a novel oncogene in rhabdomyosarcoma


ORG_STATE: CT

PHR: PROJECT NARRATIVE  This project is developing a fundamental understanding of the coupled transfers of electrons and protons, chemical processes that are ubiquitous in biology. Detailed studies of various model systems will provide insights into a range of biochemical processes that are important to the proper functioning of our cellular machinery.

PI_NAMEs: MAYER, JAMES M (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Affect;Anthracenes;Antioxidants;base;Behavior;Biochemical Process;Biochemical Reaction;Bioenergetics;Biological Models;biological systems;Biology;Carbon;Catalysis;chemical reaction;Chemicals;cofactor;Coupled;Electron Transport;Electrons;Enzymes;experimental study;Family;Free Energy;Histidine;Hydrogen;Hydrogen Bonding;insight;Location;metalloenzyme;Nature;novel strategies;Organic Chemistry;oxidation;Oxidation-Reduction;Oxidoreductase;particle;Phenols;Photosynthesis;photosystem II;Process;Property;Protons;pyridine;Reaction;Reactive Oxygen Species;Research;Respiration;Ribonucleotide Reductase;Site;Surface;System;Transition Elements;Tyrosine;Vitamin B 12

PROJECT_TITLE: Coupled Transfers of Electrons and Protons

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project focuses on the modeling and incorporation of protein three-dimensional structures across the human proteome to further our ability to describe disease-related protein-protein interaction networks in tissue- and tumor-specific contexts. These structure-informed networks will reveal mechanistic insights regarding cellular processes underlying human diseases ranging from cancer to those resulting from viral and bacterial infection. Our results will also provide hypotheses regarding drugs that can target proteins in these networks.

PI_NAMEs: HONIG, BARRY H (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Algorithms;Area;Bacterial Infections;Biological;Biology;Biomedical Research;Cell Line;Cell Physiology;Cells;Chemicals;Databases;Development;Disease;druggable target;Generations;Genes;Genetic;Genome;genome-wide;genomic data;Goals;Human;human disease;Individual;insight;Link;link protein;machine learning method;Malignant Neoplasms;Maps;Methodology;Methods;Modeling;Molecular;novel;Nucleic Acids;pathogenic bacteria;Patients;Pharmaceutical Preparations;Pharmacotherapy;Protein Analysis;protein function;protein protein interaction;protein structure;protein structure prediction;Proteins;Proteome;Research;Resources;small molecule;software development;Software Tools;structural biology;Structure;Systems Biology;three dimensional structure;Tissues;tool;tumor;Virus;Virus Diseases;Vision;Work

PROJECT_TITLE: Genome-wide structure-based analysis of protein-protein interactions and networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Hypertension

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative HIV is a chronic disease in which patients, even those well-treated, are at increased risk for heart disease when compared to the general population. Two hormones called aldosterone and brain natriuretic peptide (BNP), which have been shown to be abnormal in HIV, may be associated with inflammation as well as early changes in structure and function of the heart. This study is being conducted to evaluate whether therapies to block aldosterone and increase BNP levels may reduce the burden and progression of heart failure—an important public health issue to improve cardiovascular health.

PI_NAMEs: SRINIVASA, SUMAN  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Affect;Aldosterone;Angiotensin II Receptor;Angiotensin Receptor;antagonist;Attention;Biological Markers;Blood Vessels;Brain natriuretic peptide;Cardiac;cardiac magnetic resonance imaging;cardiometabolism;Cardiomyopathies;cardioprotection;cardiovascular health;Cardiovascular system;Chronic;Chronic Disease;Clinical;coronary fibrosis;Coupled;Data;Deposition;Development;Disease;disease model;Echocardiography;EFRAC;Endocrinology;extracellular;Failure;Fatty acid glycerol esters;FDA approved;Fibroblasts;Fibrosis;Functional disorder;GDF15 gene;General Population;Health;Heart;Heart Atrium;heart disease risk;Heart Diseases;Heart failure;heart function;HIV;Hormonal;Hormones;Hypertrophy;Image;Imaging Techniques;immune activation;Immunologics;Impairment;improved;indexing;Individual;Inflammation;Inflammatory;inhibitor;insight;Insulin Resistance;Knowledge;Left;Left Ventricular Ejection Fraction;Left Ventricular Hypertrophy;Left ventricular structure;Link;Liver;Macrophage Activation;Measures;Mediator;Metabolic;Metabolic Diseases;monocyte;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;myocardial damage;Myocardial dysfunction;Myocardium;Natriuresis;Natriuretic Peptides;Neprilysin;novel;novel therapeutics;patient population;Patients;permissiveness;Persons;pharmacologic;Phenotype;Physiological;Physiology;Placebos;Population;Populations at Risk;preservation;pressure;Prevalence;Proliferating;Public Health;Randomized, Controlled Trials;Relaxation;Renin-Angiotensin-Aldosterone System;Research Personnel;Risk;Science;Structure;sudden cardiac death;System;systemic inflammatory response;Testing;Therapeutic;Time;Tissue Inhibitor of Metalloproteinase-1;tissue injury;treatment strategy;valsartan;Vasodilation;Ventricular Remodeling;Visceral

PROJECT_TITLE: Avoiding (Heart) Failure: Physiologic-Based Targeting of the RAAS to Treat Subclinical HFpEF among PWH

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Influenza infection is a recurring public health burden and the need for better vaccines with that induce universal coverage is clear. To achieve this, basic studies of immunity to influenza in the lung are necessary. Lung residing CD8+ T cells targeting conserved antigens can provide potent, strain transcending immunity against influenza and our long-term goal is to understand how to generate and maintain these protective T cells.

PI_NAMEs: BADOVINAC, VLADIMIR P;HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Antigens;Biology;C-Type Lectins;CD8-Positive T-Lymphocytes;Cells;Cellular Immunology;Cytoprotection;Data;Development;Disease;Exhibits;extend lifespan;female reproductive tract;Generations;genetic approach;Goals;Health;Human;imaging approach;Immunity;improved;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;insight;Integrins;Intestines;Knowledge;Laboratories;Longevity;Lung;Lymphoid;Lymphoid Tissue;Maintenance;Mediastinal lymph node group;Membrane;Memory;Metabolic;Molecular;mouse model;Mus;neutralizing antibody;pandemic potential;Paper;Parabiosis;Play;Population;Principal Investigator;programs;Public Health;Recurrence;Reporting;Resistance;Role;seasonal influenza;Skin;Structure of parenchyma of lung;Symptoms;T-Lymphocyte;Time;Tissues;trait;Transcend;transcriptome;two-photon;Universal Coverage;universal influenza vaccine;Vaccines;Viral;Viral Proteins;Work

PROJECT_TITLE: Memory CD8 T cell localization and protection from influenza


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Nanotechnology;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Nanopore adaptive sampling will provide affordable, mobile sequencing for surveillance of tick vectors, rodent reservoirs, and tick-borne pathogens. We will test NAS for diagnostic accuracy (sensitivity, specificity, and threshold of detection), test for detection of a variety of in vitro grown DNA and RNA-based pathogens, differentiate closely related pathogen species and strains, develop and ground truth protocols for field testing on wild ticks and rodents from a well-characterized region, and comprehensively field test the methods and protocols in a region predicted to have the one of the highest densities of emerging rodent-associated zoonoses in the US.

PI_NAMEs: LARSEN, PETER A;OLIVER, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Anaplasma phagocytophilum;Arthropod Vectors;Arthropods;Bacteria;Bar Codes;bioinformatics pipeline;Biological;Black-legged Tick;Borrelia;Borrelia burgdorferi;Borrelia mayonii;Collection;Communities;Complementary DNA;Computer software;cost effective;Coupled;Data;Decision Making;Detection;detection test;Diagnostic;diagnostic accuracy;Disease;Disease Outbreaks;Disease Surveillance;disease transmission;DNA;Early Diagnosis;effective intervention;emerging pathogen;Eukaryota;experience;exposed human population;field study;Future;Genome;Geography;Goals;In Vitro;Incidence;Individual;Infrastructure;Internet;Kansas;Laboratories;Location;Lyme Disease;Maintenance;Maps;Measures;Metagenomics;metatranscriptomics;Methods;microorganism;Minnesota;mitochondrial genome;Molecular;Monitor;Morphology;multidisciplinary;nanopore;next generation;next generation sequencing;novel;Nucleic Acids;Nucleotides;Organism;pathogen;Pathogen detection;Pathogenicity;Peromyscus;Phylogenetic Analysis;Play;Population;portability;predictive modeling;Protocols documentation;Protozoa;Provider;Public Health;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Viruses;Rodent;Role;Sampling;Sea;skills;Source;Specific qualifier value;Specificity;Surveillance Methods;System;Technical Expertise;Techniques;Technology;Testing;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;Time;time use;tool;Training;Uncertainty;United States;Variant;vector;vector tick;vector-borne pathogen;Vector-transmitted infectious disease;Virus;Virus Diseases;Zoonoses

PROJECT_TITLE: New tools for tick-borne pathogen surveillance

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Genetic studies in human populations have found that the gene known as ABCA7 may bear on whether individuals develop Alzheimer’s disease (AD) or not. The purpose of this project is to determine biochemical functions of this gene. Longer term, the investigators would like to use the knowledge gained about how ABCA7 affects AD to develop a therapy against the disease.

PI_NAMEs: LYSSENKO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;African ancestry;Age;Age Years;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animals;Architecture;Astrocytes;ATP-binding cassette transport;Biochemical;Brain;Cell membrane;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Chromosome 21;comparative;Data;Dementia;Dimensions;Disease;Down's Syndrome;Early Onset Familial Alzheimer's Disease;Electrospray Ionization;Engineering;Etiology;European ancestry;Exhibits;extracellular;gene function;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;genome wide association study;Glioblastoma;Healthcare Systems;high density lipoprotein-1;High Density Lipoproteins;Hippocampus;Human;Individual;Induced pluripotent stem cell derived neurons;Investigation;Knowledge;Label;Late Onset Alzheimer Disease;Lecithin;Link;lipid metabolism;lipidomics;Lipids;Longevity;loss of function;loss of function mutation;Mass Spectrum Analysis;Measures;Mediating;Mediator;member;Metabolic;Microglia;mouse model;Nerve Degeneration;neural;Neuroblastoma;neuron loss;Neurons;Parietal Lobe;particle;Pathogenesis;Pathologic;Pathology;Performance;Phospholipids;Phosphotransferases;Physiology;Population;preference;Productivity;Proteins;Publishing;Radioactive;Research Personnel;Risk;Role;Shotguns;Specificity;tau Proteins;Testing;Thin Layer Chromatography;Tissues;Trisomy;Variant

PROJECT_TITLE: Specificity of ABCA7-mediated lipid efflux and its effects on intracellular lipid metabolism in neural cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE In this project, we will develop a new statistical framework to integrate genomic and transcriptomic data to define gene signatures that recapitulate the downstream oncogenic pathways underlying driver genomic aberrations in cancer. This framework will be utilized to perform secondary data analysis using a vast amount of existing cancer data generated from previous studies. Accomplishment of this project will lead to a comprehensive list of cancer-specific gene signatures and prediction models that can be used to stratify patients for directing personalized treatment in multiple cancer types, especially early-stage lung cancer.

PI_NAMEs: CHENG, CHAO  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: actionable mutation;Acute Myelocytic Leukemia;Basic Cancer Research;Biological Assay;Biological Markers;Breast;cancer genomics;Cancer Patient;Cancer Prognosis;cancer type;Clinical;clinical application;clinical phenotype;clinical predictive model;cohort;Collection;Communities;computer framework;Computer software;Data;Data Analyses;Data Set;design;Development;Disease;driver mutation;Drug Targeting;Effectiveness;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Estrogen receptor positive;Event;Frequencies;Gene Deletion;Gene Expression;Gene Expression Alteration;Gene Expression Profile;Genes;genetic signature;genomic aberrations;genomic biomarker;Genomics;Glioblastoma;Goals;immune cell infiltrate;Immunotherapy;improved;innovation;interest;Joints;Link;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;Metadata;Methods;Modeling;Mutate;Mutation;mutational status;Names;Non-Small-Cell Lung Carcinoma;Oncogenic;oncotype;Output;Pathway interactions;patient biomarkers;patient prognosis;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;personalized cancer therapy;personalized medicine;Pilot Projects;precision oncology;predict clinical outcome;predictive modeling;Probability;prognostic;prototype;Recurrence;Research;Resources;response;Risk;Sampling;Somatic Mutation;Source Code;targeted treatment;The Cancer Genome Atlas;Therapeutic;tool;TP53 gene;transcriptome sequencing;transcriptomics;Transfusion;Translating;translational cancer research;Treatment Efficacy;tumor;tumor progression;Work

PROJECT_TITLE: An innovative integrated computational framework using gene signatures for patient stratification

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE … Adult patients with heart and lung failure are sometimes supported with temporary mechanical support called extracorporeal membrane oxygenation (ECMO) and its use has increased dramatically in the United States over the last 10 years. Although ECMO is a life-saving intervention for patients, a potential complication is acute brain injury. We will examine whether ECMO causes the production of blood clots that lodge in the brain and cause stroke and whether too much oxygen may contribute to injury in this proposal and understanding these risks may enable us to suggest changes to treatment that can be tested in future studies.

PI_NAMEs: CHO, SUNG-MIN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Acute Brain Injuries;Address;Adult;Anticoagulation;Automobile Driving;Award;Biometry;Blood;Blood Cells;Blood coagulation;blood damage;Blood gas;Brain;Brain hemorrhage;Brain Injuries;Cannulations;Cardiac Surgery procedures;Cardiopulmonary Resuscitation;career;career development;Caring;Cerebral Emboli;Cerebrovascular Circulation;Cerebrum;Clinical Investigator;Clinical Trials;Clinical Trials Design;Coagulation Process;Collaborations;Complication;coronavirus pandemic;COVID-19;Critical Care;Critical Illness;Data;Data Science;Devices;Echocardiography;Embolism;experience;Exposure to;Extracorporeal Membrane Oxygenation;Frequencies;Funding;Future;Goals;Grant;Guidelines;Heart Arrest;Heart failure;Hospitals;Hour;Hyperoxia;Hypoxic-Ischemic Brain Injury;improved;Injury;Interdisciplinary Study;interest;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;left ventricular assist device;Life;lung failure;mechanical circulatory support;Mechanics;Mentors;Methodology;Methods;modifiable risk;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Nervous System Trauma;Neurologic;Neurological outcome;Neurology;neurophysiology;novel;novel coronavirus;Outcome;Oxygen;Oxygen Therapy Care;oxygen toxicity;Oxygenators;Partial Pressure;patient oriented;Patients;Perfusion;Physiology;Platelet aggregation;prevent;Production;prospective;Prospective Studies;Pump;Recommendation;Refractory;Reperfusion Injury;Reperfusion Therapy;Research;respiratory;Respiratory Failure;restoration;Risk;Risk Factors;Risk Reduction;Running;Scientist;Severities;Shock;Side;Signal Transduction;Stroke;Testing;Thrombophilia;Thrombosis;Thrombus;Tissues;Training;Transcranial Doppler Ultrasonography;Trauma;United States;United States National Institutes of Health;Venous;World Health Organization

PROJECT_TITLE: CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Seizure freedom is an elusive goal for the vast majority of the 1,000,000 Americans with drug-resistant epilepsy, yet pursuit of seizure freedom dominates epilepsy care and can overshadow other important determinants of quality of life (e.g. mental health or cognitive function). In this study, we will develop and test a mobile health tool for patients with drug-resistant epilepsy to facilitate communication of patient priorities to providers and thereby improve clinical outcomes. This work will advance a more patient-centered approach to the care of patients with neurologic disease.

PI_NAMEs: HILL, CHLOE E (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: acceptability and feasibility;American;Anticonvulsants;Caring;Clinic;Clinic Visits;Clinical;Clinical Trials;Clinical Trials Design;cognitive function;Communication;Communication Tools;comparison control;Data Analyses;Data Collection;design;Development;Effectiveness;Effectiveness of Interventions;Epilepsy;Foundations;Freedom;Future;Goals;Health Policy;Health Priorities;Health Services Research;improved;improved outcome;Individual;individual patient;innovation;instrument;Intractable Epilepsy;Measures;Mental Health;Mentorship;Methods;mHealth;Michigan;multidisciplinary;Nervous System Disorder;Neurology;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;Patients;preference;primary outcome;Process Measure;programs;prospective;Provider;Qualitative Methods;Quality of life;Randomized, Controlled Trials;Research;Research Personnel;secondary outcome;Seizures;Tablets;Testing;tool;Training;Universities;usability;user centered design;Work

PROJECT_TITLE: Optimizing Care for Patients with Drug-Resistant Epilepsy


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Hypertension is a major risk factor for heart disease, and this increased risk remains even if blood pressure is controlled. This proposal investigates the hypothesis that, in hypertension, excess activation of the mineralocorticoid receptor leads to two processes contributing to this excess risk: 1) impaired delivery of oxygen to the heart; and 2) impaired ability of the heart to generate mechanical energy and perform cardiac work. A clinical study using a mineralocorticoid receptor blocker will be performed to test this hypothesis.

PI_NAMEs: ADLER, GAIL KURR (contact);DI CARLI, MARCELO F

PROGRAM_OFFICER_NAME: SCHUM, PAULA

PROJECT_TERMS: Address;Aftercare;Albuminuria;Aldosterone;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;antagonist;Anti-Hypertensive Agents;Blood flow;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Cardiac;cardiovascular risk factor;Cardiovascular system;Chlorthalidone;Chronic;Clinical;Clinical Research;Coronary;Coupling;Diuretics;Echocardiography;Enalapril;Enzyme Inhibition;eplerenone;experimental study;Foundations;Functional disorder;Goals;Guidelines;Heart;Heart Abnormalities;Heart Diseases;heart function;Human;Hypertension;hypertension treatment;hypertensive;Impairment;improved;Individual;Knowledge;Left Ventricular Hypertrophy;mechanical energy;men;Microvascular Dysfunction;Mineralocorticoid Receptor;Morbidity - disease rate;mortality;Myocardial;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Oxygen;Oxygen Consumption;Participant;Patients;Peptidyl-Dipeptidase A;PET/CT scan;Placebos;Positron-Emission Tomography;Potassium;prevent;primary outcome;Process;Randomized;receptor;Recommendation;recruit;Relaxation;Rest;Risk;Risk Factors;Role;Stress;Structure;Testing;thiazide;Tissues;vascular abnormality;Woman;Work

PROJECT_TITLE: Mineralocorticoid receptor, coronary microvascular function, and cardiac efficiency in hypertension

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Methylmercury (MeHg) is a potent neurotoxin in both the developing and mature central nervous system with apparent indiscriminate disruption of multiple homeostatic pathways and evidence of latent and persistence and latent effects long after exposure has subsided. Here we seek to identify and understand persistent and latent effects of MeHg toxicity on biological pathways impacted by MeHg toxicity. We aim to determine if it is formally possible that latent neurotoxicity can be stopped before neurological signs appear or that established persistent effects that continue long after exposure has ceased could be reversed.

PI_NAMEs: ASCHNER, MICHAEL  (contact);BOWMAN, AARON B

PROJECT_TERMS: Address;adverse outcome;Affect;Antioxidants;Behavioral;behavioral outcome;Biological;Biological Models;Bread;Caenorhabditis elegans;Calcium;Cellular Stress;Central Nervous System;Classification;Consumption;Controlled Study;Coupled;Data;Degenerative Disorder;design;Development;developmental disease;Dose;Environmental Risk Factor;experimental study;exposed human population;Exposure to;Faeroe Islands;Fluorescence-Activated Cell Sorting;Functional disorder;Gene Expression Profiling;Genetic;genetic manipulation;Genetic Variation;Glutamates;Goals;Growth;healthy aging;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;Impairment;Incidence;Individual;Induced Neurons;Induced pluripotent stem cell derived neurons;innovative technologies;Iraq;Metabolic;Methylmercury Compounds;methylmercury exposure;mitochondrial dysfunction;Modeling;Molecular;Molecular Target;Morbidity - disease rate;Names;Nervous System Physiology;Nervous System Trauma;neural;Neurologic Signs;Neurological Models;Neurons;neuroprotection;neuropsychiatry;neurotoxic;neurotoxicity;Neurotoxins;New Zealand;novel;Outcome;Outcome Measure;Oxidation-Reduction;Oxidative Stress;Pathologic;Pathway interactions;Patients;Pattern;pharmacologic;pleiotropism;Predisposition;prevent;Process;Proteins;proteostasis;Quality Control;Research;Research Project Grants;Resources;response;Role;Severities;Seychelles;Signal Transduction;single-cell RNA sequencing;stem cell model;success;Symptoms;Synapses;System;Testing;Therapeutic;Toxic effect;Toxicology;transcriptome sequencing;Work

PROJECT_TITLE: Mechanisms of Methylmercury Induced Neuronal Toxicity


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The highly adaptive ability to reduce responses to familiar, predictable stressors, termed habituation, is disrupted in several psychiatric disorders. Our work in adult rats shows that elevations in the expression and activity of the hypothalamic orexins disrupt habituation but whether orexin actions help to explain why adolescent animals do not habituate has not been studied. This proposal seeks to understand if elevations in orexin activity we observed in adolescent rats underlies their lack of ability to habituate.

PI_NAMEs: BHATNAGAR, SEEMA  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: acute stress;Adolescence;Adolescent;Adrenal Glands;Adult;Adult women;age difference;Animals;base;Behavior;behavioral habituation;Cell Density;Cells;Chronic stress;Cognitive;Complex;Corticosterone;Data;DDX6 gene;designer receptors exclusively activated by designer drugs;Environment;Etiology;Exhibits;experimental study;Exposure to;Female;Female Adolescents;Genetic;Glucocorticoid Receptor;Glucocorticoids;habituation;Human;hypocretin;Hypothalamic structure;improved;insight;knock-down;Lead;male;Male Adolescents;Mediating;Mental disorders;Messenger RNA;Modeling;Neurobiology;Neurons;Neurosecretory Systems;neurotransmission;orexin 1 receptor;Pituitary Gland;Post-Traumatic Stress Disorders;prepro-orexin;Prevention;promoter;Rattus;receptor;receptor binding;Regulation;response;restraint;Rodent;Role;Sex Differences;Site;Small Interfering RNA;ST5 gene;Stimulus;Stress;stressor;Technology;Testing;Thalamic structure;Viral;Work

PROJECT_TITLE: Orexins actions in adolescence

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Many preclinical studies using transplanted tumor models demonstrate that radiotherapy can synergize with immune checkpoint inhibitors to generate systemic immune responses. However, clinical trials have shown that only a small percentage of patients respond well to dual therapies. This proposal is relevant to public health because it will characterize both the mechanisms through which radiation overcomes resistance to immune checkpoint inhibitors, as well as the immune system's responses to upregulated neoantigen presentation after radiotherapy. Knowledge gained from this project may reveal novel targets for enhancing responses to immunotherapy in both sarcomas and other cancer types, and, thus, contributes to the NCI's mission to alleviate the burden of cancer in patients.

PI_NAMEs: SU, CHANG  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: anti-CTLA4;anti-PD-1;anti-PD1 therapy;Antibodies;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;antitumor effect;Antitumor Response;Autophagocytosis;Bacterial Infections;Cancer Burden;cancer cell;Cancer Patient;cancer therapy;cancer type;cell killing;Cells;Clinical;Clinical Trials;Complex;CRISPR screen;cytokine;Cytotoxic T-Lymphocytes;Data;Distant Metastasis;Down-Regulation;Flow Cytometry;Genes;Genetically Engineered Mouse;genome-wide;Glycoproteins;Goals;Histocompatibility;Histocompatibility Antigens Class I;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immune response;Immune system;Immunologic Sensitization;Immunotherapy;improved;in vivo;innovation;insight;Ionizing radiation;Knowledge;Local Therapy;Lymphocytic choriomeningitis virus;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Membrane;Messenger RNA;Mission;Modeling;mouse model;Mus;neoantigens;Neoplasm Metastasis;Neoplasm Transplantation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel strategies;objective response rate;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;Phase II Clinical Trials;Play;Population;preclinical study;protein expression;Proteins;Public Health;Radiation;Radiation therapy;receptor;recombinase;Recurrence;Regimen;Regulation;Regulatory Pathway;Research;Research Personnel;Resistance;response;Role;Sarcoma;Soft tissue sarcoma;Solid Neoplasm;Surface;synergism;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;TP53 gene;transcriptome sequencing;Transplantation;tumor;Tumor Antigens;Up-Regulation;Viral Antigens;Work

PROJECT_TITLE: Dissecting the Role of Radiation in Regulation of MHC-I and Neoantigen Presentation