ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative Enterocutaneous fistula (ECF) is an abnormal connection between the bowel and skin. It can be associated with discharge of pus, feces, and stomach contents and can even lead to incontinence. The foul enteric contents act as a chemical irritant to the skin, leading to skin breakdown and predisposition to infection. The current treatment paradigm is unsuccessful; high fistula discharge, infection, and chronic inflammation lead to high failure and recurrence rates. We aim to offer a solution in the treatment of potentially fatal ECF using a minimally invasive blood derived biomaterial-based platform to occlude the fistulous tract using groundbreaking injectable shear- thinning biomaterials with anti-microbial and regenerative properties.

PI_NAMEs: KHADEMHOSSEINI, ALI ;OKLU, RAHMI  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: adhesive polymer;Adhesives;animal data;antimicrobial;Biocompatible Materials;Biological Markers;biomaterial compatibility;Biomedical Engineering;Blood;Blood Banks;Blood Platelets;Catheters;Chemicals;Chronic;Clinic;Clinical;Collaborations;Colon;Colorectal;Complex;Coupled;Creativeness;Data;Engineering;Ensure;Enteral;Enterocutaneous Fistula;Extravasation;Failure;Family suidae;Feces;Fibrin;Fistula;Fluoroscopy;follow-up;Formulation;Gel;Growth Factor;healing;Health Care Costs;Histology;Hydrogels;Image;image guided;Imaging technology;implantation;improved;In Vitro;in vitro testing;in vivo;in vivo Model;Incontinence;Infection;Inflammation;Injectable;Intensive Care Units;Intervention;Intestines;Intra-abdominal;Irritants;Lead;Literature;Magnetic Resonance Imaging;Malnutrition;mechanical properties;Medical;Mental Depression;microCT;minimally invasive;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;nano;Neck;Operative Surgical Procedures;Organ;Outcome Measure;Pain;Pancreatic enzyme;Patients;Peptide Hydrolases;Performance;Population;Postoperative Period;Pre-Clinical Model;Predisposition;prevent;Property;Proteins;Pus;Quality of life;Radiation;Rattus;Recurrence;regenerative;RNA;Rodent;Roentgen Rays;seal;Silicates;skills;Skin;Slide;Small Intestines;Stomach Content;subcutaneous;Surgeon;Surgical complication;Techniques;Testing;Therapeutic Effect;Thinness;Time;Tissues;transcriptome sequencing;Treatment Efficacy;ultrasound;Visit;wound care;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Healing enterocutaneous fistulas using bioengineered biomaterials

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hepatitis B virus (HBV) is a major human pathogen that replicates by reverse transcription of its pregenomic RNA within the viral capsid. HBV pregenomic RNA levels are regulated by the transcriptional coactivator, β-catenin, which also contributes to liver lobule zonation and hepatocellular carcinoma development. A detailed understanding of the mechanism by which β- catenin contributes to viral biosynthesis, hepatocyte metabolism and liver tumor initiation may permit the development of more effective antiviral and cancer therapies targeting the Wnt/β- catenin signal transduction pathway.

PI_NAMEs: MCLACHLAN, ALAN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: acute liver disease;Address;Anabolism;Animal Model;Anthelmintics;Anti-viral Therapy;antiviral drug development;APC gene;beta catenin;Biological Models;Capsid;Cell Culture Techniques;Cell Line;Cell Therapy;Cells;Cessation of life;Chronic;Chronic Hepatitis B;chronic liver disease;curative treatments;Data;Development;DNA Methylation;DNA-Directed DNA Polymerase;drug development;Drug resistance;Epigenetic Process;Evaluation;FDA approved;gene product;Gene Targeting;Genes;Genetic Transcription;glycogen synthase kinase 3 beta;Goals;Health;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;hepatoma cell;HepG2;histone modification;Human;human pathogen;in vivo;inhibitor;interest;knock-down;Liver;liver cancer model;Liver Cirrhosis;Liver neoplasms;Lobule;man;Mediating;Mediator;Metabolism;Modality;Molecular;mouse model;Mus;mutant;novel;Pathway interactions;Pharmaceutical Preparations;Phenotype;PI3K/AKT;polypeptide;Primary carcinoma of the liver cells;PTEN gene;Regulation;Resolution;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;Signal Transduction;Signal Transduction Pathway;Small Interfering RNA;Tamoxifen;targeted cancer therapy;targeted treatment;therapeutic target;Tissues;Transcription Coactivator;transcription factor;Transfection;Transgenic Mice;tumor;tumor initiation;Variant;Viral;Viral Genome;Viral Load result;Virus Diseases;Virus Replication

PROJECT_TITLE: Liver lobule zonation, hepatocellular carcinoma (HCC) and β-catenin mediated hepatitis B virus (HBV) biosynthesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is strongly associated with improved outcomes, thus the major challenges of NAC are (1) to bring each patient to pCR; and (2) to identify those who are at risk of metastatic recurrence in patients who do not achieve pCR. To this end, biomarkers for prediction of treatment response and accurate estimation of patients’ risk of early metastatic recurrence are needed to guide escalation or de-escalation of treatment in the neoadjuvant and adjuvant settings. In this proposed study, our overarching goal is to develop strategies for combining liquid biopsy (i.e., circulating tumor DNA) and MRI-based (i.e., functional tumor volume) measures of tumor burden to build robust predictors of response and metastatic recurrence, with the ultimate goal of improving outcomes in high-risk early breast cancer patients receiving NAC.

PI_NAMEs: LI, WEN ;MAGBANUA, MARK JESUS;VAN'T VEER, LAURA J (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adjuvant Study;Adjuvant Therapy;advanced disease;Biological Assay;Biological Markers;Blood;Breast;Breast Cancer Patient;Breast-Conserving Surgery;Cancer Burden;cancer subtypes;Characteristics;Clinical;Clinical Trials;cohort;companion diagnostics;Correlative Study;Data;deep sequencing;Detection;Diagnosis;diagnostic biomarker;Disease;Disease-Free Survival;Distant;DNA analysis;drug efficacy;Drug Evaluation;efficacy evaluation;Eligibility Determination;ERBB2 gene;experience;Exposure to;Functional Magnetic Resonance Imaging;Genetic Fingerprintings;Genomics;Goals;high risk;Hormone Receptor;Image;improved;improved outcome;In complete remission;Infrastructure;liquid biopsy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Measures;Metastatic to;Metastatic/Recurrent;Modality;Molecular;Monitor;multimodality;Mutation;Neoadjuvant Therapy;Nodal;novel therapeutics;Operative Surgical Procedures;Outcome;Pathologic;patient response;Patient risk;Patient-Focused Outcomes;Patients;Performance;phase II trial;predicting response;Prediction of Response to Therapy;predictive marker;predictive tools;primary endpoint;Primary Neoplasm;Probability;prognostic model;prognostic tool;prognostic value;Randomized;real time monitoring;Recurrence;relapse risk;Residual Cancers;Residual Neoplasm;response;Risk;Risk Assessment;Risk Marker;risk stratification;Serial Magnetic Resonance Imaging;standard of care;Testing;Therapeutic;Time;Toxic effect;treatment choice;Treatment outcome;treatment response;tumor;Tumor Burden;tumor DNA;Tumor Volume;Validation

PROJECT_TITLE: Strategy for combining circulating tumor DNA (ctDNA) and magnetic resonance imaging (MRI) measures of tumor burden for prediction of response and outcome in neoadjuvant-treated early breast cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative/Relevance To combat the growing diabetes epidemic, islet biologists are striving to develop therapies that preserve or replace lost pancreatic b-cell function and improve patients’ quality of life. To be successful, we must increase our knowledge of fundamental gene transcription and epigenetic mechanisms that drive the development and function of pancreatic b-cells. Completion of our studies will reveal how the Islet-1 transcription factor functionally interacts with the Rnf20 and/or Rnf40 ubiquitin ligases to impact histone modifications and subsequent gene expression governing mouse and human b-cell function.

PI_NAMEs: HUNTER, CHAD S (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adult;Affect;American;Architecture;Autoimmune;B-Cell Development;B-Lymphocytes;Biological Assay;blood glucose regulation;Cell Line;Cell Lineage;Cell Maturation;Cell Physiology;Cell Survival;Cells;Chromatin;chromatin remodeling;Code;combat;Complex;crosslink;Data;Data Set;Deposition;design;Development;Diabetes Mellitus;diabetic;Disease;Economic Burden;Economics;Embryo;endocrine pancreas development;Enhancers;Epidemic;Epigenetic Process;Essential Genes;expectation;experimental study;Functional disorder;functional loss;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Glucose;glucose tolerance;Goals;Healthcare;healthcare burden;Histone H2B;Histone H3;histone modification;Histones;homeodomain;Homo;Hormones;Human;humoral immunity deficiency;Hyperglycemia;Immunoprecipitation;improved;In Vitro;in vitro Assay;Individual;insight;Insulin;insulin regulation;insulin secretion;islet;Islet Cell;Islets of Langerhans;knock-down;Knockout Mice;Knowledge;Learning;lentiviral-mediated;LIM Domain;Link;Lysine;Mass Spectrum Analysis;Mediating;Messenger RNA;Methylation;Modeling;Modification;Monoubiquitination;mouse model;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;postnatal;preservation;Production;promoter;Property;Protein Binding Domain;Proteins;Publishing;Quality of life;recruit;Regulation;Reporting;Repression;Ring Finger Domain;Role;small hairpin RNA;SS DNA BP;Structure of beta Cell of islet;Therapeutic;therapy development;Transactivation;transcription factor;Transcriptional Activation;transcriptome;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: A novel link between gene regulation and histone modifications governing islet beta-cell development and function

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The chemotherapy gemcitabine is the most widely used agent in pancreatic cancer due to its well tolerated profile, even though treatment only marginally extends survival. We found that macrophages within pancreatic tumors facilitate resistance to gemcitabine by releasing metabolites that competitively inhibit gemcitabine cytotoxic activity. This research proposal will define how macrophages create and release these metabolites and then use this information to enhance the efficacy of this well-tolerated chemotherapy.

PI_NAMEs: LYSSIOTIS, COSTAS ANDREAS (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Anabolism;Bypass;cancer cell;Cancer Etiology;cell type;Cells;Cessation of life;Chemoresistance;chemotherapeutic agent;chemotherapy;clinic ready;clinical application;Clinical Treatment;Communication;cytotoxic;Data;Deoxycytidine;Deoxycytidine Kinase;Diagnosis;Disease;Drug Delivery Systems;Drug Metabolic Detoxication;effective therapy;Evolution;Fibroblasts;Future;gemcitabine;Generations;Human;Immune;Immunocompetent;Impairment;in vivo;Incidence;Infiltration;inhibitor;insight;interstitial;Isotopes;Label;Liquid substance;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Modeling;Molecular;mouse model;novel;Nucleic Acids;nucleoside analog;Nucleosides;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Play;predicting response;Process;Prodrugs;Production;Property;Publishing;Pyrimidine Nucleosides;Reaction;Reporting;Research Proposals;Resistance;response;Role;Scheme;Signal Pathway;Signal Transduction;standard of care;Survival Rate;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapy resistant;Thick;three dimensional cell culture;Toxic effect;Translations;tumor;Tumor-associated macrophages;United States;uptake;Vascularization

PROJECT_TITLE: Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative: The goal of this project is to understand the role of HOTTIP mediated aberrant R-loops in CTCF boundary function, leukemic TAD formation, and pathogenesis of AML. Our studies will unveil the mechanisms by which HOTTIP lncRNA and CTCF boundary fine-tune WNT/β-catenin target TAD formation and transcription to modulate HSC behavior and leukemogenesis. Our project will define novel function of R-loops in lncRNA mediated CTCF boundary activity and AML genome organization.

PI_NAMEs: HUANG, SUMING  (contact);XU, MINGJIANG

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;beta catenin;Binding;Binding Sites;Biological;cell behavior;Cell Line;ChIP-seq;Chromatin;chromatin isolation by RNA purification sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;cohesion;Collaborations;Data;Data Set;Disease;DNA;Enhancers;Epigenetic Process;Gene Expression Profile;Gene Mutation;Genetic Transcription;Genome;genomic locus;Genomics;Goals;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hi-C;Homeobox Genes;Hybrids;improved;leukemia;leukemic transformation;leukemogenesis;Mediating;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mutation;novel;Output;overexpression;Pathogenesis;programs;promoter;Regulation;RNA;RNA immunoprecipitation sequencing;Role;Sampling;Site;Structure;success;Testing;Transcriptional Regulation;transcriptome sequencing;transgene expression;Transgenic Organisms;Untranslated RNA;Work

PROJECT_TITLE: Role of lncRNA mediated R-loops in CTCF boundary function and AML genome organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-H(02)M]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative  Obesity is important risk factors in pathogenesis of skeletal muscle insulin resistance and type 2 diabetes. However, the mechanisms by which Western diet and associated activation of the renin angiotensin– aldosterone system promote metabolic syndrome are poorly understood. Understanding the biochemical pathways leading to the muscle insulin resistance and diabetes should provide new strategies in diabetes prevention.

PI_NAMEs: JIA, GUANGHONG  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipocytes;Aldosterone;arteriole;Biochemical Pathway;blood glucose regulation;Blood Vessels;Carbohydrates;CD36 gene;Cell membrane;Cells;Consumption;Data;Deposition;Diabetes Mellitus;Diabetes prevention;Diet;Disease;Docking;early detection biomarkers;Early Diagnosis;Endothelial Cells;Endothelium;Enhancers;exosome;Fatty acid glycerol esters;Fatty Acids;Functional disorder;Gene Expression;glucose metabolism;High Fat Diet;hormone regulation;Impairment;In Vitro;in vivo;Insulin;Insulin Resistance;insulin sensitivity;intercellular communication;lipid metabolism;Lipids;Macrophage;Maintenance;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;MicroRNAs;Mineralocorticoid Receptor;Modeling;Multivesicular Body;Mus;Muscle;Muscle Fibers;Muscle function;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Organ;palmitoylation;paracrine;Pathogenesis;Physiological;Plasma;Prevention;promoter;Protein Family;Proteins;Receptor Activation;Receptor Cell;receptor expression;Receptor Signaling;recruit;Renin-Angiotensin-Aldosterone System;response;Risk Factors;Role;saturated fat;Signal Induction;Signal Transduction;Skeletal Development;Skeletal Muscle;skeletal muscle metabolism;sugar;Tissues;trafficking;Transcription Factor AP-1;translocase;uptake;Vascular blood supply;Vascular Endothelial Cell;vascular endothelial dysfunction;western diet;Work

PROJECT_TITLE: Endothelial mineralocorticoid receptors in diet-induced skeletal muscle insulin resistance

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Disturbances in the assembly and disassembly of RNA granules has recently emerged as the key defect underlying common neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). This project seeks to understand the molecular basis of RNA granule assembly and how this process is disturbed in disease. These insights will be used to guide therapeutic intervention for ALS and related degenerative diseases.

PI_NAMEs: TAYLOR, JOSEPH PAUL (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;base;Cytoplasm;Cytoplasmic Granules;Cytoplasmic Inclusion;Defect;Degenerative Disorder;Deposition;Disease;Frontotemporal Dementia;Gene Expression;Genes;Inclusion Bodies;insight;Molecular;Mutation;Myopathy;Nervous System Disorder;Neurodegenerative Disorders;Pathogenesis;Pathologic;Process;programs;Proteins;Research;RNA;RNA metabolism;RNA-Binding Proteins;Role;Therapeutic Intervention

PROJECT_TITLE: Dynamic RNA-protein assemblies and neurological disease


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Incisional hernia (IH) persists as an unsolved major surgical health problem with a significant prevalence, insufficient treatments, broad stakeholder impact, diverse risk factors, and challenging epidemiology. Our proposal addresses barriers to IH prevention through multi-source clinical data designed to elucidate and discover key mechanistic drivers of hernia and enable development of performance-optimized, user-informed, parsimonious, specialty-specific models for use within a clinical decision support mobile user interface (CDS-MUI) that will be tested to identify strategies for widespread implementation. This work will lead to a broad, significant, and sustained impact on the field, catalyzing a major pivot towards hernia prevention and enabling precise risk prediction for surgery patients.

PI_NAMEs: FISCHER, JOHN PATRICK (contact)

PROJECT_TERMS: Abdomen;acceptability and feasibility;Address;Adoption;Affect;Algorithms;Behavior;behavior change;Biological Factors;Biomechanics;Caring;Clinical;clinical care;Clinical Data;clinical decision support;clinical practice;clinical translation;Code;Consensus;Data;Data Set;Data Sources;Databases;Decision Making;design;Development;Diagnostic;Dissemination and Implementation;diverse data;Economic Burden;Effectiveness;effectiveness trial;Electronic Health Record;Enabling Factors;Epidemiology;Evidence based intervention;Expenditure;Feedback;Focus Groups;follow-up;Future;future implementation;Genetic Diseases;Health;Healthcare;Hernia;Housing;implementation protocol;implementation science;implementation strategy;improved;improved outcome;Informed Consent;innovation;interdisciplinary collaboration;Intervention;Knowledge;Laboratories;Link;Machine Learning;Measurable;Measures;medical specialties;Methods;Mission;Modeling;Natural Language Processing;Nutritional;Operative Surgical Procedures;Outcome;patient population;Patients;Performance;Perioperative;personalized predictions;Physiological;Pilot Projects;portability;pragmatic implementation;predictive modeling;Prevalence;Prevention;prophylactic;Provider;Qualitative Methods;repaired;Reporting;Research;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Software Engineering;Source;stakeholder perspectives;supervised learning;Surgeon;surgery outcome;Surgical incisions;Techniques;Testing;United States National Institutes of Health;usability;Validation;Variant;virtual;Work

PROJECT_TITLE: Improving surgical outcomes through optimized hernia prediction

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Violence Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Due to physical harms suffered because of persecution in their home countries, asylum-seekers and refugees have significantly high rates of traumatic brain injury (TBI), leading to cognitive impairment that is a substantial source of morbidity for affected individuals, their families, and society. This career development award will adapt and evaluate the first ever cognitive rehabilitation intervention that is culturally tailored, trauma-informed, and delivered by community health workers using video-based telemedicine to address the unique needs of asylum-seekers and refugees.

PI_NAMEs: SAADI, ALTAF  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Advisory Committees;Affect;Agreement;Alzheimer's Disease;Area;arm;Attention;Award;barrier to care;Behavioral Model;Brain Concussion;brain health;Bypass;career;Caring;Client satisfaction;Clinical;Clinical Research;Clinical Trials Design;Cognitive;cognitive rehabilitation;Communities;community engaged approach;community engaged intervention;Community Health Aides;cost;Country;court;dementia risk;design;disability;Disabling;Disparity;disparity reduction;Economic Burden;Effectiveness;effectiveness trial;Employment;Enhancement Technology;Epidemiology;Equity;ethnic health disparity;ethnic minority;Evaluation;evidence base;executive function;Exercise;experience;Facilities and Administrative Costs;Family;Feedback;Focus Groups;Foundations;Future;Health;health care delivery;health care disparity;health disparity;health disparity populations;health equity;health equity promotion;Healthcare;Heterogeneity;high risk;Home;Immigration;Impaired cognition;improved;Individual;information gathering;Institute of Medicine (U.S.);Interpersonal Violence;Intervention;intervention delivery;intervention refinement;Interview;K-Series Research Career Programs;Legal;Linguistics;low and middle-income countries;marginalized population;medical specialties;Memory;Mentorship;Methods;mild traumatic brain injury;Modeling;Morbidity - disease rate;multidisciplinary;National Institute of Neurological Disorders and Stroke;Neurobehavioral Manifestations;Neurologist;neuropsychiatry;Outcome;Participant;Patients;Perception;Persons;Population;Post-Concussion Syndrome;preference;Prevalence;primary outcome;Procedures;psychoeducation;Questionnaires;racial disparity;racial minority;randomized trial;Recommendation;Refugees;Rehabilitation therapy;Reporting;Research;Research Methodology;Research Personnel;Research Proposals;Sampling;satisfaction;secondary outcome;skills;social stigma;Societies;Source;Spanish/English;Strategic Planning;Surveys;Symptoms;System;Technology;Telemedicine;Testing;Therapeutic Intervention;Therapeutic Studies;Time;Torture;Training;translational model;Transportation;Trauma;trauma exposure;Traumatic Brain Injury;Trust;Underserved Population;United States National Institutes of Health;Variant;Veterans;Violence;Visual;Vulnerable Populations;Waiting Lists;War;Work

PROJECT_TITLE: A Culturally-Adapted, Trauma-Informed Cognitive Rehabilitation Intervention for Asylum-Seekers and Refugees with Traumatic Brain Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Certain proteins can regulate cancer and development by regulating gene expression on chromatin. This project will study a fundamental biophysical property of an important protein that is critical in regulating gene expression in cancer and stem cell development. Results from this work will provide important mechanistic insights into how this fundamental property protects us from cancer and also supports development.

PI_NAMEs: JIANG, HAO  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Binding;Biochemical;Biological;Biological Assay;Biological Process;biophysical analysis;biophysical properties;Biophysics;Cancer Biology;cancer cell;Cancer Cell Growth;Cell Differentiation process;Cells;Chimeric Proteins;ChIP-seq;Chromatin;chromatin modification;Core Protein;CRISPR/Cas technology;demethylation;Development;Developmental Process;Disease;embryonic stem cell;Engineering;Enhancers;EP300 gene;Gene Expression;Genes;Genetic Transcription;genome editing;Genomics;Histones;Homologous Gene;Human;Impairment;In Vitro;insight;Kabuki Make-Up Syndrome;Liquid substance;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;Missense Mutation;Molecular;Mouse Embryonic Stem Cells;mutant;Mutate;Mutation;neoplastic cell;Neurodevelopmental Disorder;novel;Patients;Phase;Physical condensation;Physiological;Process;programs;Property;Protein Dynamics;protein purification;Proteins;Publications;reconstitution;recruit;Regulation;RNA Splicing;Role;Stem Cell Development;stem cell differentiation;System;Transcription Initiation Site;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Variant;Work;Y Chromosome

PROJECT_TITLE: Role of UTX condensation in chromatin regulation

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

PHR: NARRATIVE: PUBLIC HEALTH IMPACT Epilepsy affects 1 in 100 people with most patients opting not to undergo potentially curative surgical intervention because of the invasiveness of open brain surgery. Making matters worse, 1% of all epilepsy patients (500,000 worldwide – each year!) will die suddenly for unexplained reasons, and even for those who live, 30% will face continual seizures because all available drugs will fail for them. This project focuses on providing a minimally invasive way to achieve the benefits of surgery without opening the skull, through use of a steerable needle delivered through the patient's cheek, with thermal therapy delivered to the brain and monitored in real time using MR imaging.

PI_NAMEs: BARTH, ERIC JOHN (contact);WEBSTER, ROBERT JAMES

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3D Print;Ablation;Address;Affect;Amaze;Anatomy;Brain;brain surgery;Cadaver;Cessation of life;Cheek structure;Clinical;clinical translation;Collaborations;Craniotomy;cranium;Curative Surgery;curative treatments;design;design and construction;Diagnosis;Disadvantaged;Disease;Dose;Effectiveness;Electrodes;Ensure;Environment;Epilepsy;Excision;experimental study;Face;Feedback;foramen ovale;Freedom;Geometry;High Prevalence;Hippocampus;Hour;Image;image guided;Imaging Techniques;industry partner;innovation;Intervention;Knowledge;Lasers;Letters;Life;Magnetic Resonance Imaging;Mechanics;Medical Imaging;Methods;minimally invasive;Monitor;Morbidity - disease rate;Movement;multidisciplinary;Needles;novel;Operative Surgical Procedures;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;Postoperative Period;Prevalence;Procedures;Protocols documentation;Public Health;Research;Research Personnel;Risk;Robot;robotic system;Robotics;Route;Safety;Scanning;Seizures;Shapes;skull base;success;Surgeon;System;Systems Integration;Technology;Temperature;Temporal Lobe Epilepsy;Thermal Ablation Therapy;Thermometry;Time;time use;Tissues;United States;Validation;Variant;Work

PROJECT_TITLE: An MRI-Guided Steerable Needle to Replace Open Brain Surgery for Epilepsy Patients


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative We have identified a role for the heat shock protein (HSP) receptor CD91 in initiation of immune responses against nascent, emerging tumors. These immune responses are central for immunosurveillance of cancer, a concept proposed over a hundred years ago. In this proposal we aim to examine the interaction of CD91 with its ligands, the HSPs, on hematopoietic cells in situ as the mechanism that leads to productive anti-tumor immune responses. By understanding this immunological pathway we will solve an outstanding question that is central to cancer immunology and also be better able to predict individuals that have poor CD91 function and are more susceptibility to developing cancer.

PI_NAMEs: BINDER, ROBERT J (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Adoptive Transfer;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Automobile Driving;Binding Proteins;Cells;Chemicals;Clinical;conditional knockout;Cross Presentation;Cross-Priming;cytokine;Data;Dendritic Cells;Development;Event;Evolution;Foundations;Generations;Genetic Polymorphism;Heat shock proteins;Hematopoietic;HIV;Human;Immune;Immune response;Immune system;Immunity;Immunologic Surveillance;Immunologics;Immunology;In Situ;Individual;insight;Knockout Mice;Knowledge;Laboratories;Lead;Ligands;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;Modeling;Molecular;Molecular Chaperones;Mus;Mutation;Natural Killer Cells;neoantigens;NK Cell Activation;novel;Outcome;Pathway interactions;Peptides;Population;Positioning Attribute;Predisposition;prevent;Productivity;prognostic;Publishing;Qualifying;receptor;Research;Resistance;response;Role;Shapes;Signal Transduction;Stimulus;T cell response;T-Lymphocyte;tool;tumor;Tumor Antigens;Tumor Escape;tumor immunology;Tumor-Derived;Vaccination;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: CD91 and cancer immunosurveillance

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Data Science

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative This UCSF training grant (DaTABASE) will provide training in advanced data analytics to predoctoral researchers studying behavioral and social determinants of health. The program is a collaboration between the UCSF Department of Epidemiology and Biostatistics, Bakar Computational Health Sciences Institute, and the Center for Health and Community. Unique strengths of the program include 1) a focus on health disparities; 2) exceptional clinical and population data sources; and 3) integrating advanced machine learning methods into causal frameworks for actionable results.

PI_NAMEs: BROWN, WILLIAM  (contact);GLYMOUR, MEDELLENA MARIA;HSWEN, YULIN ;PRATHER, ARIC ANDREW

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: behavioral and social science;Data Science;Databases;Health;programs;Research;Training

PROJECT_TITLE: UCSF Data Science Training to Advance Behavioral and Social Science Expertise for Health Research (DaTABASE) Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed project aims to provide the first systematic functional characterization of a novel category of genomic features, translated small Open Reading Frames. This research is relevant to public health because new functional annotations at these regions of the human genome will bring clarification to the coding and non- coding classification of the human transcriptome, which will be useful in interpreting molecular mechanisms and predicting functional impacts of genetic variants linked to these loci.

PI_NAMEs: WANG, SIDNEY  (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: 5' Untranslated Regions;Active Sites;Amino Acids;Area;Biological;Biological Process;Biology;Biomedical Research;Catalogs;Categories;Cell Culture Techniques;Cell Survival;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Codon Nucleotides;Computing Methodologies;CRISPR library;CRISPR screen;Culture Media;Data;design;DNA Sequence;Dropout;Drosophila genus;Evaluation;Event;Evolution;experimental study;fitness;follow-up;Foundations;Frequencies;functional genomics;Future;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Screening;Genetic study;genetic variant;Genome;genome annotation;genome wide association study;genome-wide;genomic data;Genomic Segment;Genomics;Goals;Guide RNA;Human;Human Genome;improved;Initiator Codon;Learning;Link;Literature;loss of function;lymphoblastoid cell line;Macaca mulatta;Maps;Mass Spectrum Analysis;Medicine;Mendelian disorder;Messenger RNA;Methods;Modernization;Molecular;Molecular Weight;Mus;muscle physiology;Natural Selections;novel;Open Reading Frames;Pan Genus;Pathway interactions;Pattern;Peptides;Periodicity;Play;Preparation;Primates;Production;programs;Proteins;Proteomics;Protocols documentation;Public Health;Research;Research Design;reverse genetics;ribosome profiling;Ribosomes;Role;Sampling;Sequence Alignment;Shotguns;Signal Transduction;Skeletal Muscle;tandem mass spectrometry;Testing;Transcript;transcriptome;Translating;Translations;Untranslated Regions;Untranslated RNA;Vertebrates

PROJECT_TITLE: Expanding the known coding genome: identifying biological function for novel tORFs

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Appendiceal adenocarcinoma (AA) is a rare orphan malignancy for which there is a great lack of both clinical trials data and molecular understanding to guide treatment. In this project we will develop a working knowledge base of the genetic alterations that underlie this disease, and pursue development of actionable genetic tests to guide critical AA treatment decisions.

PI_NAMEs: MILLER, LANCE DAVID (contact);VOTANOPOULOS, KONSTANTINOS

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adenocarcinoma;Anatomy;Appendix Adenocarcinoma;Behavior;Biological;Biopsy;Cancer Patient;Characteristics;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Classification;Clinical;clinical application;Clinical Data;Clinical Management;clinical translation;Clinical Trials;cohort;Colon Carcinoma;comparative;Custom;Data;design;Development;Disease;DNA Sequence Alteration;Drug resistance;Drug Screening;drug sensitivity;drug testing;drug-sensitive;effective therapy;Eligibility Determination;Exclusion;Exhibits;experience;Future;Gene Expression;Gene Mutation;Genes;Genetic;genetic testing;genomic data;Genotype;Goals;Greater sac of peritoneum;Guidelines;high risk;hospice environment;Hyperthermia;improved;Institution;Intervention;intraperitoneal therapy;Knowledge;knowledge base;Left;Literature;Malignant neoplasm of appendix;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Modeling;Molecular;molecular subtypes;Morbidity - disease rate;mortality;Mutation;Nodule;novel;Oncogenic;Operative Surgical Procedures;Organoids;Orphan;Outcome;palliative chemotherapy;Pathway interactions;Patients;personalized medicine;personalized strategies;Pharmaceutical Preparations;Phenotype;prognostic;Prognostic Marker;prognostic model;prospective;Publishing;Recurrence;Reporting;Research;Resolution;response;Role;Sampling;Series;Specimen;survival prediction;Survivors;Target Populations;targeted exome sequencing;Testing;Therapeutic;therapy outcome;Tissues;Training;Transcription Alteration;Translating;translational potential;treatment choice;treatment response;tumor;Tumor Debulking;Unresectable;Validation;Work

PROJECT_TITLE: Establishing the Repertoire of Actionable Alterations in Appendiceal Adenocarcinoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: PROJECT NARRATIVE: One-in-four adults hospitalized for community-acquired pneumonia experience an adverse cardiac event. This is, in part, the result of Streptococcus pneumoniae invasion of cardiomyocytes. Herein, we determine how glucose limitation experienced by intracellular pneumococci enhances their production of cytotoxic pneumolysin and hydrogen peroxide; together resulting in cardiomyocyte death.

PI_NAMEs: ORIHUELA, CARLOS J (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acetates;acetyl phosphate;Adult;Adverse event;Antibodies;Antioxidants;Area;Arrhythmia;Attenuated;Autopsy;Bacteremia;Blood;Blood Circulation;Carbon;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;Cell Death;cell killing;Cell membrane;Cells;Cessation of life;clinical epidemiology;community acquired pneumonia;cytotoxic;Disease;Drops;Enzymes;epidemiology study;Event;experience;experimental study;Formates;Gene Expression;Genes;Glucose;Glucose-6-Phosphate;Goals;Gram-Positive Bacteria;Gram-Positive Cocci;Heart;heart damage;Heart failure;Heart Injuries;Hospitalization;Human;Hydrogen Peroxide;In Vitro;in vivo;Individual;Inflammatory;Invaded;Ions;Learning;Lesion;Link;Metabolic;Metabolism;Microbial Biofilms;mortality;Mus;mutant;Mutation;Myocardial;Myocardial Infarction;Myocardium;nonhuman primate;oxidative damage;Passive Immunization;Pathogenesis;Pneumococcal Infections;Pneumonia;Process;Production;programs;prototype;Pyruvate;Pyruvate Metabolism Pathway;Pyruvate Oxidase;Research;Risk Factors;Role;Sampling;Seminal;Streptococcus;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;targeted treatment;tempol;Testing;Therapeutic Intervention;Toxin;transcriptome sequencing;uptake;Virulence;Work

PROJECT_TITLE: Cardiac microlesion formation during invasive pneumococcal disease

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The goal of this this application is to determine the functions of the trypanosome RNA binding protein, DRBD18, in controlling alternative polyadenylation and cell phenotype. DRBD18 is essential in both human and insect stage T. brucei, and conserved in kinetoplastid parasites. The proposed studies will significantly increase our mechanistic understanding of this essential protein in these medically and economically important parasites.

PI_NAMEs: READ, LAURIE K. (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Adverse effects;Affect;Africa South of the Sahara;African Trypanosomiasis;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological;Biological Process;Biology;Cells;Cis-Acting Sequence;Complement;Data Set;Development;Disease;economic impact;Economics;Elements;Epidemic;Exclusion;Exhibits;fexinidazole;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Markers;Genetic Transcription;Goals;Health;Heterogeneity;Human;Infection;Insecta;insertion/deletion mutation;insight;knock-down;Knowledge;Leishmania;Link;Livestock;Mediating;Medical;Messenger RNA;nagana;nanopore;neglect;new therapeutic target;novel;Open Reading Frames;Oral;Parasites;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Poly A;Polyadenylation;Population;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;prevent;Proteins;Regulation;Relapse;RNA;RNA Binding;RNA Interference;RNA-Binding Proteins;Role;single-cell RNA sequencing;Site;Spliced Leader Sequences;Testing;Trans-Splicing;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Translations;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Variant;vector-borne

PROJECT_TITLE: Alternative polyadenylation regulation in Trypanosoma brucei

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE We have uncovered a new functional link between the ARID1A chromatin remodeler and the process of mRNA translation elongation important for urothelial cell maintenance and cancer pathogenesis. This discovery is clinically significant, as ARID1A-deficient cancers are exquisitely sensitive to inhibition of translation elongation initiation. Our goal is to definitively investigate the functional link between chromatin remodeling and protein synthesis control, as well as determine the therapeutic implications of targeting this interface.

PI_NAMEs: HSIEH, ANDREW CALEB (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Animal Model;ARID1A gene;Biology;Bladder;cancer genome;Cancer Patient;carcinogenesis;Cell Maintenance;cell transformation;Chromatin;chromatin protein;chromatin remodeling;clinical application;clinically significant;Complex;Conflict (Psychology);Coupled;Data;Disease;DNA Damage;Elongation Factor;Epithelial Cells;Epithelial Physiology;Epithelium;fitness;Gene Expression;Genes;Genetic;Genetic Transcription;genome sequencing;Genotype;Goals;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;Laboratories;Link;loss of function mutation;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Messenger RNA;Modality;Modeling;Molecular;mouse model;mRNA Translation;Mus;Mutate;Mutation;Natural History;novel;novel therapeutic intervention;Nucleotides;Oncogenic;Organoids;parity;Pathogenesis;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peptide Elongation Factor 2;pharmacologic;Phenotype;polysome profiling;Population;precision medicine;prevent;Process;Production;prognostic;programs;Proliferating;Protein Biosynthesis;Proteins;PTEN gene;Regulation;Research;response;restoration;restraint;Specimen;System;Therapeutic;TP53 gene;Transcript;transcriptome;translational impact;Translational Repression;Translations;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Urothelial Cell;Urothelium;Work

PROJECT_TITLE: Transcriptional-translational conflict in bladder epithelial homeostasis and cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Failure of the functionally mature state of insulin-secreting beta cells in the pancreas (sometimes called beta cell de-differentiation) under conditions of obesity and insulin resistance leads to diabetes. Recent evidences support a hypothesis that five new genetic regulators control the functionally mature beta cell state. The goals of this application are to elucidate the mechanism(s) by which these five regulators control mature beta cell state and to identify strategies to manipulate their expression or activity as means to prevent beta cell failure in diabetics.

PI_NAMEs: BLUM, BARAK  (contact)

PROJECT_TERMS: Adult;Affect;autoimmune pathogenesis;Behavior;Beta Cell;Biological Process;blood glucose regulation;cell dedifferentiation;Cell Maturation;Cell Physiology;Chronic stress;Collaborations;Consensus;Coupled;data platform;Data Set;Development;Diabetes Mellitus;diabetic;diabetogenic;Disease;environmental stressor;Etiology;Failure;Functional disorder;functional restoration;Gene Expression;gene therapy;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;In Vitro;in vivo;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Maps;Metabolic stress;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pancreas;Peripheral;pharmacologic;Phenotype;postnatal development;predictive modeling;prevent;Process;Reporting;Signal Pathway;stem cells;Stress;System;Testing;transcriptome sequencing;type I and type II diabetes

PROJECT_TITLE: Genetic control of mature beta cell function and identity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Interstitial lung diseases (ILDs) including idiopathic and other forms of pulmonary fibrosis are a major and growing medical burden. Fibrosis progression in these diseases is driven by the persistent activation of fibroblasts; understanding how fibroblasts become activated and then locked in fibrogenic states is central to the development more effective therapies for fibrotic ILDs. The proposed studies will test the role and regulation of the transcription factor Runx1 in fibrogenic cell activation and memory in mouse models and human tissue, potentially identifying a novel targetable mechanism underlying fibrotic ILD progression.

PI_NAMEs: TSCHUMPERLIN, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: ATAC-seq;Atomic Force Microscopy;Attenuated;Binding;Biochemical;Biomechanics;Bleomycin;Cell Separation;Cells;ChIP-seq;Chromatin;Collagen;Data;Data Set;Deposition;Development;Disease;Disease Progression;DNA Binding;effective therapy;Elements;Epithelium;Exhibits;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;Genes;Genetic Transcription;genomic locus;Hematopoietic;Homeostasis;Human;human disease;human tissue;In Situ;in vivo;Injury;Interstitial Lung Diseases;knock-down;Label;Link;Location;Lung;lung injury;mechanical signal;Mechanics;Medical;Memory;Mesenchymal;Mesenchyme;microscopic imaging;Modeling;mouse model;Mus;novel;Play;Population;programs;protein expression;Publishing;Pulmonary Fibrosis;Regulation;Resolution;response;restoration;RNA Interference;Role;Signal Transduction;single-cell RNA sequencing;Slice;small molecule;Sorting;Structure of parenchyma of lung;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transforming Growth Factor beta;Translating;Work;wound healing

PROJECT_TITLE: Fibrogenic activation and memory in the lung mesenchyme

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Diabetes;Nutrition;Prevention

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project narrative The research described in the current proposal is highly pertinent to public health because the discovery of factors that restore and/or prevent conversion to hyperglycemia will provide new therapeutic targets to ameliorate pre-diabetes. The current research proposal and the knowledge gained and mechanical details dissected fits the purview of NIDDK’s mission to reduce burden of diabetes.

PI_NAMEs: THURMOND, DEBBIE C (contact);VELUTHAKAL, RAJAKRISHNAN

PROJECT_TERMS: Acute;Apoptosis;Beta Cell;Blood Glucose;blood glucose regulation;cardiovascular risk factor;Cell model;Cell Physiology;Cell surface;cell type;Cells;Circulation;Cities;Data;Defect;Development;Diabetes Mellitus;diabetogenic;Diet;Disease;Environment;Epidemic;Event;Exposure to;F-Actin;Failure;Fasting;Fatty acid glycerol esters;Functional disorder;Funding;Glucose;Glucose Intolerance;glucose uptake;GLUT 4 protein;Goals;Health;High Fat Diet;Human;human tissue;Hyperglycemia;impaired glucose tolerance;improved;in vivo;innovation;Institution;Insulin;insulin granule;Insulin Resistance;insulin secretion;insulin sensitivity;Intake;Intervention;islet;knock-down;Knock-out;Knowledge;Link;Mechanics;Mediating;Mission;Mitochondria;mitochondrial dysfunction;Molecular;mortality;mouse model;Mus;Muscle Fibers;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;p21 activated kinase;Pathway interactions;Peripheral;Persons;Population;Prediabetes syndrome;Predisposition;prevent;Prevention;Process;Proteins;Public Health;Research;Research Proposals;Role;Sampling;Secretory Cell;Signal Pathway;Signal Transduction;Skeletal Muscle;Stimulus;Stress;Stroke;Structure;Structure of beta Cell of islet;Testing;Therapeutic;therapeutic target;Tissues;tool;Translations;Vesicle;Work

PROJECT_TITLE: Targeting an atypical signaling hub to restore and protect whole body glucose homeostasis


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The co-assembly of two synaptic nanoscopic structures that release and restore neurotransmitters is at the core of information processing in the brain and is altered in psychiatric disorders. This proposal investigates the pathways that co-assemble these essential machineries. This provides fundamental insights into information processing and into pathways affected in brain disease.

PI_NAMEs: EMPERADOR MELERO, JAVIER  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Affect;Amino Acid Sequence;amphiphysin;Binding;Biological Assay;Brain;Brain Diseases;Cell Line;Cell membrane;Cells;Clathrin Adaptors;Data;Dynamin;Dynamin I;Electrons;Electrophysiology (science);Endocytosis;Engineering;Ensure;Enzymes;Excitatory Synapse;experience;experimental study;Genes;Goals;Grant;in vivo;information processing;Inhibitory Synapse;insight;Invertebrates;Knock-out;Knockout Mice;Knowledge;Learning;Liquid substance;Literature;Measures;Mediating;Mental disorders;Methodology;Modeling;Molecular;mutant;Mutation;nano;nanoscale;Neurons;Neurotransmitters;Pathway interactions;Phase;Phenotype;PHluorin;Physical condensation;Positioning Attribute;postsynaptic;presynaptic;presynaptic neurons;Property;Proteins;reconstitution;recruit;Recruitment Activity;Role;scaffold;Signal Transduction;Site;skills;Solid;Structure;superresolution microscopy;Synapses;Synaptic Potentials;Synaptic Receptors;Synaptic Transmission;Synaptic Vesicles;Testing;tool;Training;transmission process;Vertebrates;Vesicle;vesicular release;Visualization;Work

PROJECT_TITLE: Molecular Mechanisms for Co‐Assembly of Endocytic and Exocytic Machineries at a Synapse

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed project will test an innovative intervention that integrates financial coaching into a smoking cessation program for low-income smokers. Study results will address large gaps in knowledge about how to reduce tobacco use among low-income adults, with emphases on applying socio-contextual theory and behavioral economic theory to target financial stress, delay discounting, and attention as barriers to quitting in this highly vulnerable population.

PI_NAMEs: ROGERS, ERIN  (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;Adult;arm;Attention;behavioral economics;Biochemical;Budgets;Cognitive;compare effectiveness;comparison intervention;coping mechanism;cost;cost comparison;cost effectiveness;cost estimate;Counseling;Data;design;discounting;economic determinant;effectiveness testing;Eligibility Determination;empowerment;Enrollment;experience;Face;Financial Hardship;follow-up;Funding;Goals;group intervention;Health;Health Benefit;health care settings;improved;Income;income disparities;innovation;Intervention;intervention participants;Investigation;Knowledge;Link;long term abstinence;Low income;Low Income Population;Motivation;nicotine replacement;novel;Outcome;Outcome Assessment;Participant;Patient Self-Report;Persons;primary outcome;programs;Randomized;Randomized, Controlled Trials;recruit;reduce tobacco use;Reporting;safety net;satisfaction;Services;Smoke;Smoker;Smoking;smoking cessation;social;success;Surveys;Testing;theories;Tobacco;Tobacco use;Tobacco Use Cessation;treatment arm;treatment as usual;Treatment Efficacy;usual care arm;Vulnerable Populations

PROJECT_TITLE: A behavioral economic intervention for low-income smokers

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Genetics;Infectious Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE Catheter-associated urinary tract infections (CAUTIs) are the most common cause of hospital- associated infections and can result in severe disease and increased mortality. This proposal seeks to define the host-pathogen interactions, and specifically the contribution of the virulence factor urease, that facilitate CAUTI caused by Staphylococcus aureus in catheterized individuals. Additionally, this research will provide the platform for the career development of a young investigator focused on translating basic science research in host-pathogen interactions, molecular microbiology, and novel drug development into clinically useful interventions to improve patient care.

PI_NAMEs: WALKER, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 2-hydroxypyridine;Accounting;Affect;Age;age effect;age group;Aging;Ammonium;Bacteremia;Bacteria;Basic Science;Binding;Binding Sites;Bioinformatics;Bladder;Blood;burden of illness;Carbon;Carbon Dioxide;career development;catheter associated UTI;Catheterization;Catheters;Chronic;Clinical;clinically relevant;Collection;Complex;Data;Development;Disease;drug development;Elderly;Environment;Enzyme Inhibition;Enzyme Kinetics;Enzymes;Epithelium;Equipment Malfunction;Escherichia coli;Exhibits;Genetic;Genetic Transcription;Genomics;Genus staphylococcus;Gram-Positive Cocci;Health Sciences;Healthcare Systems;high risk;Holoenzymes;Hospitals;Hydrolysis;implantable device;improved;In Vitro;Incontinence;Individual;Infection;infection rate;infection risk;Inflammation;insight;interdisciplinary approach;Intervention;irritation;life span;lonely individuals;Medical center;Medical Device;Methicillin Resistance;Microbial Biofilms;Microbial Genetics;Microbiology;Modeling;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Multi-Drug Resistance;Mus;Mutation;Neurogenic Bladder;Nosocomial Infections;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Operon;Organ;pathogen;Pathogenicity;Patient Care;Patients;Population;Pre-Clinical Model;Predisposition;Prevention strategy;programs;Proteins;Proteus mirabilis;Quality of life;Recombinants;Regulatory Element;Regulon;Reporting;Research;Research Personnel;Role;Shock;Signal Transduction;Single Nucleotide Polymorphism;small molecule;Stains;Staphylococcus aureus;Surface;Symptoms;Testing;Texas;Training;Translating;translational scientist;Translations;treatment strategy;Universities;Urea;Urease;urinary;Urinary tract;Urinary tract infection;Urine;Uropathogen;Virulence;Virulence Factors

PROJECT_TITLE: Defining Host-pathogen Interactions in CAUTI to Guide Novel Drug Development

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE MLL-rearrangement (MLL-r) affects about 10% acute leukemia patients and is associated with poor prognosis. This proposal has immediate clinical relevance in developing a more advanced treatment to MLL-r leukemias, and will contribute to a broader understanding of how the dynamic epigenetic networks control oncogene expression in cancers and therapeutic responses. The technology developed in this project will facilitate functional domain discovery for future targeted therapies.

PI_NAMEs: CHEN, CHUN-WEI DAVID (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acetylation;Achievement;Acute leukemia;Affect;Animals;Arginine;Binding;Biochemical;Bromodomain;cancer type;Cell Line;Cells;chromatin modification;Classification;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Combined Modality Therapy;Complex;CRISPR library;CRISPR screen;drug discovery;Elements;Epigenetic Process;Future;Gene Expression;Gene Expression Regulation;Gene Rearrangement;Genes;Genetic;genetic approach;Genetic Screening;genome-wide;Goals;Histone Acetylation;histone acetyltransferase;Histone Deacetylation;Histone H3;histone methylation;Histones;Human;improved;in vivo;Infant Leukemia;inhibitor;innovation;insight;Lead;Left;leukemia;leukemogenesis;Lysine;Maintenance;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;MLL gene;MLL-AF9;MLL-rearranged leukemia;Monitor;multiple omics;Nature;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Pharmacologic Substance;Phase I Clinical Trials;Positioning Attribute;pre-clinical;Prognosis;programs;protein folding;Proteins;Publishing;Reader;recruit;Regimen;Reporting;Research;response;Role;SAGA;Scanning;Signal Transduction;SIRT1 gene;Surface;Survival Rate;Tail;targeted treatment;Technology;Therapeutic;Toxic effect;Transcriptional Activation;treatment response;Work;World Health Organization

PROJECT_TITLE: Mechanism and therapeutic opportunities of targeting the Tudor domain


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: We will identify a fundamental mechanism that determines the distance between origins of DNA replication in human cells. This mechanism is a key determinant of genome stability and the rate of cell division, and accordingly it is a key determinant of therapeutic response in the medical and radiation oncology clinic.

PI_NAMEs: BAKKENIST, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: adaptive immune response;Attenuated;Binding;Binding Proteins;cancer cell;Cancer Model;CD8-Positive T-Lymphocytes;CDC2 gene;CDC7 gene;Cell division;Cell Lineage;Cell Nucleus;Cells;CHEK1 gene;Chromosomal Instability;Chromosome 1;Chromosomes;Clinic;Clinical Trials;Complement;Conformal Radiotherapy;Data;DNA biosynthesis;DNA Damage;DNA replication fork;DNA replication origin;Eukaryota;Fire - disasters;Fluorescence;Fluorescence Resonance Energy Transfer;Genome;Genome Stability;Half-Life;helicase;Human;Human Chromosomes;Human Genome;Immune response;Immunotherapy;In Vitro;in vivo;innovation;insight;Irradiated tumor;kinase inhibitor;Length;Licensing;lymph nodes;Medical Oncology;Molecular;Molecular Conformation;mouse model;Mus;Normal Cell;novel;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Proliferating;Protein phosphatase;Radiation;Radiation Oncology;radiation response;Regulation;Replication Initiation;Replication Origin;Replicon;Reporter;Reporting;Role;S phase;Signal Transduction;Stress;superresolution microscopy;T-Lymphocyte;Testing;Time;treatment response;tumor

PROJECT_TITLE: DNA damage signaling to dormant origins of replication

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Services;Nutrition;Prevention;Telehealth

PHR: PROJECT NARRATIVE Receiving a diagnosis of prediabetes does not always result in developing diabetes. Substantial reduction in the risk of developing diabetes can be made through lifestyle changes, like adopting a healthier diet and increased physical activity; however, for older people access to support systems for achieving a healthy weight and exercise program can be restricted. Our study examines ways to increase access for older adults to support a healthy lifestyle.

PI_NAMEs: BEASLEY, JEANNETTE MICHELE (contact);CHODOSH, JOSHUA

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Adult;Age;American;arm;behavior change;Body Weight decreased;Clinic;Clinical;Communities;compare effectiveness;Consolidated Framework for Implementation Research;cost;Cost Analysis;COVID-19 pandemic;Data;Dentition;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Diagnosis;Diet;digital;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation study;Elderly;Electronic Health Record;Eligibility Determination;evidence base;Evidence based intervention;exercise intervention;exercise program;experience;Faculty;Federally Qualified Health Center;follow-up;Future;Geriatrics;Glycosylated hemoglobin A;Goals;good diet;Group Practice;Health;health care settings;Healthcare;healthy lifestyle;healthy weight;hearing impairment;Hospitalization;Hospitals;human old age (65+);implementation barriers;implementation cost;implementation evaluation;implementation framework;implementation outcomes;implementation study;Incidence;Individual;informant;Institution;Intervention;intervention program;Interview;Length of Stay;Life Style;lifestyle intervention;Measures;Medicare;Methodology;Monitor;older adult;Older Population;Outcome;Outcome Assessment;Participant;Patients;Persons;Physical activity;Policies;Population;Prediabetes syndrome;prevent;Prevention strategy;primary outcome;Private Practice;Process;programs;Public Health;Qualifying;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Risk;Risk Reduction;rural setting;secondary outcome;Self Efficacy;Seminal;Social support;Support System;systemic barrier;Technology;telehealth;theories;Time;tool;Travel;treatment as usual;trial design;Visit;Visual impairment;Weight;Weights and Measures;Work

PROJECT_TITLE: BRinging the Diabetes Prevention Program to GEriatric Populations (BRIDGE)

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Pediatric;Prevention;Rare Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Mutations in the gene that encodes the type I ryanodine receptor (RYR1) in skeletal muscle are the most common causes of malignant hyperthermia susceptibility (MHS) and environmental heat stroke (EHS). For unknown reasons, families with RYR1 mutations display variability in penetrance, expressivity, and genetic discordance. This project will define the molecular mechanisms that underlie variability in MHS/EHS penetrance, expressivity, sex-bias, and genetic discordance, as well as provide new information on the complex interplay of environment and genetics in these disorders.

PI_NAMEs: DIRKSEN, ROBERT T;DOWLING, JAMES J;HAMILTON, SUSAN L (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Age;Body Temperature;Caffeine;Cause of Death;Cessation of life;Clinical;Complex;Coupling;Dantrolene;Data;Development;Disease;DNA Methylation;Dominant-Negative Mutation;effective therapy;Environment;Epigenetic Process;epigenome;Event;Exercise;Exhibits;Exposure to;Family;Fatty-acid synthase;Feedback;Female;Fever;Frequencies;Genes;Genetic;Glycolysis;Goals;Heat Stress Disorders;Heat Stroke;Heritability;Heterozygote;Human;Incidence;Individual;inhibitor;intergenerational;Life Experience;Macromolecular Complexes;male;Malignant hyperpyrexia due to anesthesia;Measures;Mediating;Metabolic;metabolomics;Military Personnel;Modification;Molecular;mouse model;Mus;muscle form;Mutation;novel strategies;offspring;Operative Surgical Procedures;Outcome;Partner in relationship;Pathogenicity;Patients;pediatric patients;Penetrance;Predisposition;prevent;Prevention;Production;protein expression;Proteins;Reporting;response;Role;Ryanodine Receptor Calcium Release Channel;RyR1;Sarcoplasmic Reticulum;Serum;Severities;sex;Sex Bias;Skeletal Muscle;skeletal muscle metabolism;Teenagers;Temperature;Testing;Thermogenesis;transgenerational epigenetic inheritance;transmission process;Variant;young adult

PROJECT_TITLE: Environmental and Epigenetic Modifiers of Susceptibility to Malignant Hyperthermia and Environmental Heat Stroke


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Acute myeloid leukemia (AML) is a devastating blood cancer with limited therapeutic options. Relapse is the main cause of treatment failure, most likely due to the persistence of tumor precursor cells (leukemia initiating/stem cells) that are resistant to current treatments. It remains a critical challenge to develop effective therapeutics to eradicate these cells. The project proposed in this application seeks to target the metabolic vulnerability of these cells through inhibition of PTPMT1 that plays an important role in cell energy production. If successful, this effort may lead to a novel strategy to deplete these root cells in AML.

PI_NAMEs: QU, CHENG-KUI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Agonist;Animals;Antibiotics;Bioenergetics;cancer cell;CDKN1C gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Death Induction;Cells;Characteristics;conditional knockout;Cytosol;Data;dental agent;Development;DNA Damage;experience;Fermentation;FLT3 gene;Glucose;Glycolysis;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;human model;Impairment;inhibitor;Knock-out;Knockout Mice;leukemia;leukemia initiating cell;leukemic stem cell;Local Anti-Infective Agents;Maintenance;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;MLL-AF9;Modeling;Molecular;mouse genetics;Mus;neoplastic cell;novel;novel strategies;Oncogenes;Outcome;oxidation;Oxidative Phosphorylation;Patients;Pharmaceutical Preparations;pharmacologic;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Play;Population;Positioning Attribute;PPAR gamma;precursor cell;Predisposition;Process;Production;Proliferating;Property;PTEN gene;Pyruvate;pyruvate carrier;Reactive Oxygen Species;Relapse;Research;Resistance;response;Role;rosiglitazone;self-renewal;Stem Cell Development;stem cells;Stress;Structure;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutically effective;Treatment Failure;tumor;tumor metabolism;Type 2 diabetic;uptake;Warburg Effect;Xenograft Model

PROJECT_TITLE: Targeting leukemic stem cells in acute myeloid leukemia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Maternal Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Vaccine Related;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The HIV Centers for Underrepresented Populations in Research Clinical Trials Unit (CURE CTU) will be comprised of six highly experienced research sites located at Texas Children’s Hospital, Baylor College of Medicine in Houston, TX, Ann & Robert H. Lurie Children’s Hospital of Chicago, IL, Northwestern University, St. Jude Children’s Research Hospital and the University of Tennessee Health Science Center in Memphis, TN, University of Miami, Holtz Children’s Hospital, Miami, FL, Children’s National Medical Center in Washington, DC, and the University of California, San Diego, CA; each located in an area targeted by the U.S. initiative to end the HIV epidemic. The CURE CTU is the only unit specifically focused on research in pregnant women, women, children, adolescents and young adults less than 25 years in the continental U.S. funded through NIAID. The Specific Aims of the CURE CTU address many of the targeted high priority areas of the 4 NIAID proposed Networks.

PI_NAMEs: SPECTOR, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent woman;Affect;Age;age acceleration;aging related disease;AIDS clinical trial group;Anti-Retroviral Agents;anti-viral efficacy;Area;Behavioral;Biological;California;Cardiovascular Diseases;Characteristics;Chicago;Child;Childhood;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Unit;co-infection;college;comorbidity;County;design;Disease remission;District of Columbia;Drug Combinations;drug distribution;Early identification;Enrollment;Epidemic;ethnic difference;ethnic diversity;ethnic minority;Evaluation;experience;Fetal Development;Funding;Geographic Locations;Health Benefit;Health Sciences;Hepatitis B;Hepatitis B Virus;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-infected adolescents;Hormonal Change;Immune response;Immune system;improved;Infant;Infant Health;Infection;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Licensure;Maternal Health;Medical center;medication safety;Medicine;Mental disorders;Mental Health;Metabolic;Methods;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;Neurologic;Neuropsychology;neutralizing antibody;novel;Nutritional;Obesity;older adult;Opiate Addiction;Outcome;Pediatric Hospitals;Persons;Physiological;Population;Postpartum Women;pre-exposure prophylaxis;Pregnancy;Pregnant Women;prevent;Prevention;Prevention strategy;Principal Investigator;Quality of life;Race;racial difference;racial minority;recruit;Research;response;Risk;Safety;Saint Jude Children's Research Hospital;Sexually Transmitted Diseases;Site;social;System;Target Populations;Technology;Tennessee;Texas;therapy design;transmission process;Underrepresented Populations;Universities;user-friendly;Vaccination;Viral;Virus Diseases;Washington;Woman;young adult;Youth


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma and encompasses molecular subtypes with contrasting biology and clinical outcome. Conventional chemo- and immuno-therapy combinations fail to cure approximately 40% of DLBCL patients, and this relapsed/refractory population has a very poor prognosis. Investigating the molecular drivers of poor outcome and how these may be targeted with rational therapeutic strategies is likely to improve the outcome of these patients and have a substantial impact on public health.

PI_NAMEs: GREEN, MICHAEL RICHARD (contact)

PROJECT_TERMS: 18q;activated B cell like;anergy;Automobile Driving;B-Cell Antigen Receptor;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;Biology;Bromodomains and extra-terminal domain inhibitor;Cell Death;Cell Line;Cells;Chromosome 18;Chromosome Arm;Chronic;Clinical;clinical heterogeneity;Combination immunotherapy;Complex;Development;Disease;DNA copy number;Down-Regulation;Event;Genes;Genetic;Genus Mentha;Hematopoietic Stem Cell Transplantation;Immunoglobulins;Immunophenotyping;improved outcome;Inhibition of Apoptosis;inhibitor;Investigation;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Lymphomagenesis;Malignant - descriptor;Measures;Mediating;Molecular;molecular marker;molecular phenotype;molecular subtypes;Monitor;mouse model;Mus;mutant;Mutation;MYC gene;Non-Hodgkin's Lymphoma;novel;Oncogenes;Oncogenic;Outcome;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Play;Population;pre-clinical;Pre-Clinical Model;precision medicine;prevent;Prognosis;Property;Proteins;Public Health;receptor expression;Receptor Signaling;Recurrence;Refractory;Relapse;resistance mechanism;risk stratification;rituximab;Role;Signal Transduction;single-cell RNA sequencing;Structure of germinal center of lymph node;Subgroup;synergism;TCF7L2 gene;Testing;Therapeutic;therapeutic target;tositumomab;transcription factor;Transgenic Mice;tumor;Work

PROJECT_TITLE: Functional characterization and rational therapeutic targeting of 18q DNA copy number gains in diffuse large B-cell lymphoma


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative People are exposed to per- and polyfluoroalkyl substances daily from multiple sources. Epidemiological studies show an association between serum PFAS concentrations and lower bone density in both children and adults. Here, we investigate a new in vivo model to study the mechanism through which PFAS impair bone health.

PI_NAMEs: SCHLEZINGER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adolescent;Adult;Adult women;Adverse effects;Age;aging population;American;American diet;Attention;Biochemical;Biological;Blood;bone;bone cell;Bone Density;bone health;bone loss;bone metabolism;bone quality;Carboxylic Acids;Cell Physiology;cell type;Chemical Exposure;Chemistry;Child;constitutive androstane receptor;consumer product;contaminated drinking water;Data;Databases;defined contribution;Detection;Diagnosis;Diet;drinking water;Eating;epidemiologic data;Epidemiology;epidemiology study;Estrogen Receptors;Ethers;Etiology;experience;experimental study;exposed human population;Exposure to;Female;Food;Foundations;fracture risk;Genotype;Health;healthy aging;Histologic;Homeostasis;Human;immune system function;Impairment;improved;In Vitro;in vivo evaluation;in vivo Model;Industrialization;Investigation;Knockout Mice;Life;life span;Light;lipid metabolism;Lipids;Liver;Long-Term Effects;male;mathematical model;Measures;men;Mental Health;Metabolic;Modeling;Monitor;mortality;Mus;National Health and Nutrition Examination Survey;Natural regeneration;Nature;novel;Nuclear Receptors;Occupational Exposure;old mice;Osteoblasts;Osteoclasts;Osteoporosis;osteoporosis with pathological fracture;Pathway interactions;perfluorooctanoic acid;Perinatal;Persons;Phenotype;physical conditioning;Play;Poly-fluoroalkyl substances;Population;Positioning Attribute;PPAR alpha;pregnane X receptor;Process;Public Health;Quality of life;Receptor Signaling;Reporting;Research;Risk;Role;Sampling;Serum;Source;Structure;Sulfonic Acids;Testing;Therapeutic Effect;Tissues;Toxic Environmental Substances;toxicant interaction;transcriptome;transcriptomics;Wild Type Mouse;Woman;women's outcomes

PROJECT_TITLE: Investigating the Perturbation of Bone Health by Per/Polyfluoroalkyl Substances

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative This proposal studies a protease-activated receptor, named PAR2, as an unexpectedly important regulator of metabolism that significantly impacts fatty liver, cholesterol and sugar metabolic pathways. Here, we provide a path to understanding the mechanistic basis of PAR2 in regulating liver metabolism and the validation of PAR2 as a novel point of therapeutic intervention.

PI_NAMEs: KULIOPULOS, ATHAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: ADD-1 protein;Adipose tissue;Affect;American;antagonist;Applications Grants;beta-arrestin;Biochemical;blood glucose regulation;Body Weight decreased;Carbon;Cell membrane;cell type;Cholesterol;Cholesterol Homeostasis;Cirrhosis;Clinical Data;Coagulation Process;cohort;Consumption;Coupled;Cross-Sectional Studies;Data;diabetic;diet-induced obesity;Dyslipidemias;effective therapy;Etiology;Extracellular Domain;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibrosis;G-Protein-Coupled Receptors;Glucose;Glucose Transporter;GLUT-2 protein;Glycogen;glycogenesis;Goals;GTP-Binding Proteins;Hepatic;Hepatocyte;Homeostasis;Human;hypercholesterolemia;Hypertriglyceridemia;In Vitro;in vivo;Inflammation;Insulin;Insulin Resistance;Intestines;Knock-out;Knockout Mice;Kupffer Cells;LDL Cholesterol Lipoproteins;Ligands;Link;lipid metabolism;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver metabolism;liver transplantation;Macrophage;MAP Kinase Gene;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;Modeling;mortality;mouse model;Mus;N-terminal;Names;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obese Mice;Obesity;Obesity Epidemic;PAR-1 Receptor;PAR-2 Receptor;Pathogenesis;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Pilot Projects;Plasma;Primary carcinoma of the liver cells;protein expression;Proteinase-Activated Receptors;Proto-Oncogene Proteins c-akt;Ramp;receptor;release of sequestered calcium ion into cytoplasm;resistance mechanism;reverse cholesterol transport;Role;Signal Pathway;Signal Transduction;Site;Specimen;SRE-2 binding protein;sugar;Surface;Technology;Testing;Therapeutic Intervention;Thinness;Tissues;Trypsin;United States National Institutes of Health;Validation;Visceral

PROJECT_TITLE: Metabolic Reprogramming by Protease-activated Receptor 2

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: BOZEMAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative  This project addresses a critical gap in knowledge regarding the prospective role of social connectedness in shaping health for the Blackfeet American Indian community, a health disparity population. The findings from this longitudinal investigation will elucidate biopsychosocial pathways which may connect social connectedness to health-relevant outcomes in the Blackfeet community. This knowledge will inform future health interventions for the Blackfeet community and AI communities with similar values and health disparities.

PI_NAMEs: JOHN-HENDERSON, NEHA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Alcohol consumption;American Indian community;American Indian Population;American Indians;anxiety symptoms;assessment application;Biological Markers;biopsychosocial;Blackfeet;Blood;Blood Pressure;Blood specimen;C-reactive protein;Cardiometabolic Disease;Cardiovascular Diseases;Cellular Phone;Childhood;Chronic Disease;Communities;County;Cross-Sectional Studies;cultural health;cultural values;cytokine;Data Collection;depressive symptoms;Diabetes Mellitus;Disease;disorder risk;Ecological momentary assessment;Environment;experience;Fasting;Future;Generalized Anxiety Disorder;Glucose;Glycosylated hemoglobin A;Goals;Growth;Health;Health Disparities Research;health disparity;health disparity populations;High Density Lipoprotein Cholesterol;Hypertension;improved;improvement on sleep;Incidence;indexing;Inflammatory;inflammatory marker;Insulin;Interleukin-1;Intervention;Investigation;Knowledge;Left;Life Expectancy;Loneliness;Longitudinal Studies;low density lipoprotein triglyceride;Measurement;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;mobile application;Modeling;Monitor;Montana;Not Hispanic or Latino;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Patients;Pattern;perceived discrimination;Pharmaceutical Preparations;physical conditioning;Pittsburgh Sleep Quality Index;poor sleep;prospective;Publications;Questionnaires;racial population;Recording of previous events;Reporting;Research;Reservations;resilience factor;Rest;Risk;Risk Factors;Role;Shapes;Sleep;sleep quality;Smoking Status;social;social implication;Social Interaction;Social Network;TNF gene;Trauma;Vulnerable Populations;waist circumference;Work;Wrist

PROJECT_TITLE: Social Connectedness and Health in the Blackfeet Community: An Investigation of Biopsychosocial Mediators


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Anti-insulin B cells (AIBCs) create type 1 diabetes (T1D) liability, yet the processes by which AIBCs acquire insulin-binding B cell receptors and expand early in human T1D are not clear. To address this knowledge deficit, we will determine AIBC phenotypic and B cell receptor attributes, and how they change as pre- symptomatic T1D TrialNet participants progress towards diabetes. These studies are required to enable future investigation of AIBC changes as sensitive biomarkers to predict diabetes onset and identify favorable clinical trial responses.

PI_NAMEs: BONAMI, RACHEL H (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Address;Affinity;analysis pipeline;antigen binding;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;Avidity;B cell clonality;B cell differentiation;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;B-Lymphocytes;Beta Cell;Binding;biobank;Biological Assay;Biological Markers;Blood;Blood Volume;candidate identification;Cell Death;Cell Differentiation process;Cell secretion;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Clinical;Clinical Trials;Clonal Evolution;Clonal Expansion;Coal;Code;Dangerousness;Data;defined contribution;Detection;Diabetes Mellitus;Disease;Disease Progression;Early identification;Epitope Mapping;Epitopes;Event;experimental study;Future;Germ Lines;glucose tolerance;Goals;Heterogeneity;Human;human monoclonal antibodies;Hybridomas;IA-2 protein;Immune response;Immune signaling;Immune Targeting;Immune Tolerance;Immunoglobulin Genes;Immunoglobulin-Secreting Cells;Immunoglobulins;immunological intervention;impaired glucose tolerance;inclusion criteria;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Investigation;Investigational Therapies;islet;islet cell antibody;Islets of Langerhans;Knowledge;Lymphoma;Maps;Measures;Memory;Memory B-Lymphocyte;molecular sequence database;Monitor;Mus;Mutate;Mutation;Participant;Pathogenicity;Pathologic;Pathway interactions;Patients;peripheral blood;Phenotype;Population;predictive marker;prevent;Process;Production;Recombinants;relapse prediction;research clinical testing;response;Risk;Role;Sampling;screening;Sequence Analysis;Serinus;Shapes;Signal Transduction;single cell analysis;Sorting;Specificity;Structure of germinal center of lymph node;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Time;Visit

PROJECT_TITLE: The Origins of Human Anti-Insulin B Lymphocytes in Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The majority of human neurological and psychiatric disorders involve impairment in learning and memory. This research program delves into the process of memory formation, with a focus on the brain mechanisms that mediate forgetting, how the brain organizes memories, and the roles for genes that suppress memory formation. The knowledge obtained from these studies will provide new information that may lead to diagnostics or therapies for brain disorders.

PI_NAMEs: DAVIS, RONALD L (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Area;Arousal;Behavioral;Biology;Brain;brain disorder therapy;cellular imaging;Code;Cognition;Cues;design;Diagnostic;Experimental Genetics;flexibility;forgetting;gene function;Genes;Genetic Screening;Human;imaging genetics;Impairment;innovation;insight;Knowledge;Learning;Logic;long term memory;Mediating;Medical;Memory;memory process;Mental disorders;MicroRNAs;Molecular;Molecular Biology;Molecular Genetics;Nervous System Disorder;neuron component;Neurons;Neurosciences;novel;Phase;Process;programs;Property;Proteins;Research;response;Rewards;Role;Sensory;Signal Transduction;Sleep;stem;Suppressor Genes;System;Visualization

PROJECT_TITLE: Biology of memory


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: The proposal addresses molecular mechanisms behind sexual dimorphism of autoimmune diseases and the role that commensal microorganisms play in it.

PI_NAMEs: CHERVONSKY, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Adopted;Adverse reactions;Affect;Androgen Receptor;Animals;Antigens;Area;Attenuated;Autoimmune Diseases;Autoimmune Process;Autoimmunity;Bone Marrow;Breeding;cell type;Cells;commensal microbes;Computing Methodologies;Data;Development;diabetic;Disease;Disease Progression;Environmental Risk Factor;Evolution;experimental study;feeding;Female;Fetus;flexibility;Foundations;Future;Gene Expression;Gene Expression Regulation;Gene Modified;Genetic Drift;Genetic Models;Germ-Free;Gnotobiotic;Goals;Gonadal Steroid Hormones;Hormonal;hormone regulation;Hormones;Immune;Immune signaling;Immune system;imprint;Infection;Insulin-Dependent Diabetes Mellitus;Interferon Type II;male;Mediating;Microbe;microbial;microbiota;microorganism;Modeling;Molecular;Mothers;Multiple Sclerosis;Mus;Myeloid Cells;Non obese;Organism;Pathway interactions;Phosphoric Monoester Hydrolases;Play;Pregnancy;Prevalence;prevent;Process;Property;Receptor Signaling;Regulation;Research;Resistance;Role;Scleroderma;sex;Sex Bias;Sex Chromosomes;sexual dimorphism;Signal Transduction;Sjogren's Syndrome;Systemic Lupus Erythematosus;Systems Development;T-cell receptor repertoire;T-Lymphocyte;Testing;Thymus Gland;Time;timeline;transcription factor;Vaccination

PROJECT_TITLE: Host's and microbiota's contribution to sexual dimorphism of autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-D(02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Endocrine Disruptors;Infertility;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: This work will greatly improve our understanding about how phthalates cause early reproductive aging in females. In turn, this work will set the foundation for the identification and development of novel targets for the treatment of phthalate-induced diseases, including early reproductive aging.

PI_NAMEs: FLAWS, JODI A. (contact);NOWAK, ROMANA A.;RAETZMAN, LORI T

PROJECT_TERMS: Acceleration;Acute;Adhesives;Adult;Age;Aging;angiogenesis;antagonist;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;B-Lymphocytes;Binding;Biological Assay;cardiovascular disorder risk;CD4 Positive T Lymphocytes;Cell Aging;Cell Count;Cells;Cessation of life;Characteristics;Childbirth;Chronic;consumer product;Curcumin;cytokine;Data;Defoaming Agents;Delayed Childbearing;Development;diminished ovarian reserve;Disadvantaged;Disease;Dose;early experience;early onset;Endocrine Disruptors;Environment;environmental chemical;epidemiology study;experience;exposed human population;Exposure to;Female;female reproductive system;Fertility;Fibrosis;Follicle Stimulating Hormone;Foundations;Gene Expression;Gene Expression Profiling;Greater sac of peritoneum;Growth;Health;Hormones;human tissue;Hypothalamic structure;IL8 gene;Immune;Immunohistochemistry;improved;Infertility;Inflammasome;Inflammation;Inflammatory;inhibin B;Interferons;Interleukin-10;Interleukin-6;ITGAM gene;KISS1 gene;Lubricants;Macrophage;Medical Device;men;Menopausal Symptom;Mental Depression;mono-(2-ethylhexyl)phthalate;Mus;Natural Killer Cells;novel;Osteoporosis;Ovarian Follicle;Ovary;Pathway interactions;Peritoneal Macrophages;personal care products;Pesticides;phthalates;Physiological;Pituitary Gland;Play;Population;Premature Menopause;Proliferating;protein expression;Public Health;Publishing;RANTES;Reporter;Reproduction;reproductive;Reproductive Health;reproductive longevity;reproductive senescence;Risk;Role;Serum;Signal Pathway;Solvents;subfertility;System;T-Lymphocyte;Testing;Time;Tissues;Uterus;Woman;Women's Health;Wood material;Work

PROJECT_TITLE: Phthalate Exposure and Female Reproductive Aging

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rare Diseases;Social Determinants of Health;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Hanson’s disease (HD), more commonly known as leprosy, is a zoonotic infection in the United States. Transmission to humans by blood-feeding arthropods (insects and ticks) has long been suspected. This project seeks to examine the interaction between Mycobacterium leprae and vector ticks to better understand the ecology of this ancient disease.

PI_NAMEs: MACALUSO, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Amblyomma;Anxiety;Area;Arthropod Vectors;Arthropods;Bacteria;Biological;Biology;Blood;California;Case Study;Cell Culture Techniques;Cells;Country;Data;Data Set;Development;Diagnosis;disability;Disease;Ecology;Environment;Epidemiology;Etiology;Family Dasypodidae;feeding;field survey;Florida;Genetic Transcription;Goals;Hawaii;health care availability;help-seeking behavior;Horizontal Disease Transmission;Human;In Vitro;in vivo;in vivo Model;Indigenous;Individual;Infection;Insecta;Laboratories;Leprosy;Louisiana;mycobacterial;Mycobacterium leprae;New York;Newly Diagnosed;novel;Organism;pathogen;pathogenic bacteria;Patients;Persons;Publishing;Punishment;Recording of previous events;Reporting;Research;Resources;Role;Route;Skin;social stigma;Socioeconomic Status;Source;Stigmatization;System;Testing;Texas;tick feeding;tick saliva;Ticks;Time;Transcript;transcriptome;transcriptome sequencing;transmission process;Travel;United States;vector;vector competence;vector tick;Virulence;Vulnerable Populations;Zoonoses

PROJECT_TITLE: Exploiting the arthropod vector: novel mechanisms of Mycobacterium leprae transmission

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PHR: Project Narrative Autism affects the brain’s capacity to interpret and respond to social information, including human faces. This study will advance our understanding of how early brain development associated with visual face learning in the first two years of life relates to social ability in autism. Our developmental neurobiological approach has potential to provide a novel biomarker of a specific and foundational social skill, which could in turn inform early detection and intervention.

PI_NAMEs: CASCIO, CARISSA J (contact);MCGUGIN, RANKIN W

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 5 year old;Adult;Affect;Age;Age Months;Algorithms;Anatomy;Anterior;Anterolateral;association cortex;Autism Diagnosis;autism spectrum disorder;awake;Behavior;Behavioral;Bilateral;Brain;Brain region;Calibration;Caregivers;Characteristics;Clinical;collateral sulcus;Data;Data Set;Development;Diagnosis;Diagnostic;Early Diagnosis;Early identification;Early Intervention;Equipment and supply inventories;Exhibits;experience;Exposure to;Face;face perception;Face Processing;Foundations;Functional Magnetic Resonance Imaging;fusiform face area;Fusiform gyrus;Growth;Handedness;high risk;high risk infant;Human;Impairment;Individual;individuals with autism spectrum disorder;Infant;Lead;Learning;learning ability;Left;Life;Link;Location;Longitudinal Studies;Measures;Minor;Morphology;morphometry;MRI Scans;myelination;neural;Neurobiology;novel marker;Outcome;Pervasive Development Disorder;Positioning Attribute;predicting response;prenatal;Property;Publishing;rate of change;repetitive behavior;Resources;response;Risk;Sampling;Scanning;Sensory;Severities;social;Social Behavior;social cognition;social communication;Social Functioning;social skills;Social skills development;Socialization;Specific qualifier value;Specificity;Structure;Surface;Symptoms;System;Temporal Lobe;Testing;Thick;Third Pregnancy Trimester;timeline;Toddler;ventral visual stream;Visual;Visual System;Work

PROJECT_TITLE: Development of brain structure supporting face learning in infants at risk for autism

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Standard-of-care prostate cancer treatments targeting the androgen receptor transcription factor exert selective pressures that can lead to the emergence of lineage plasticity phenotypes that are difficult to treat and poorly-understood. This proposal seeks to understand the role and therapeutic potential of a stem cell transcription factor that is up-regulated by prostate cancer treatments and promotes early events in prostate cancer lineage plasticity. We will test the efficacy of blocking this stem cell transcription factor, as well as inhibiting its downstream targets, to treat, prevent, or reverse the emergence of lineage plasticity in prostate cancer.

PI_NAMEs: DEHM, SCOTT M. (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: abiraterone;addiction;advanced disease;advanced prostate cancer;Affinity;Anchorage-Independent Growth;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;antagonist;Automobile Driving;Basal Cell;Benign;Biology;Biopsy;Castration;Cell Line;Cell Lineage;cell type;Cells;Cessation of life;ChIP-seq;Chromatin;Classification;Clinical;clinical development;Clinical Trials;Data;Data Set;Development;Disease;drug sensitivity;effective therapy;efficacy testing;Endocrine;enzalutamide;Epithelial Cells;Epithelium;ERBB2 gene;Event;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Genomic approach;Genomics;Growth;hormone therapy;In Vitro;in vivo;inhibitor;knock-down;Knockout Mice;Ligands;male;Malignant neoplasm of prostate;Malignant Neoplasms;migration;Modeling;Neurosecretory Systems;novel therapeutic intervention;Oncogenes;Oncogenic;Organoids;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pressure;prevent;Prevention;Process;programs;Prostate;prostate cancer cell;Prostate Cancer therapy;Prostatic Neoplasms;Recurrence;Resistance;Resistance development;Role;spatiotemporal;Specific qualifier value;Stains;standard of care;Stanolone;stem cells;Stress;synergism;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic evaluation;therapeutic target;therapeutically effective;therapy resistant;Tissues;transcription factor;transcriptome sequencing;treatment strategy;tumor;Tumor Biology;Tumor Suppressor Proteins;United States;Up-Regulation

PROJECT_TITLE: Targeting early events in prostate cancer lineage plasticity