NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Neurosciences;Prevention;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE This project will advance our knowledge on 1) changes in the inner ear vestibular organs associated with viral infection induced balance dysfunction, 2) characterize and establish the Lassa Fever surrogate model ML29-infected mice to assess balance function changes, and 3) the effective timing and modality for treatment of balance dysfunction induced by a viral infection.

PI_NAMEs: MAKISHIMA, TOMOKO  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Acute;Acute Disease;Affect;Africa;Anatomy;Animal Model;Behavior;behavior change;behavior test;Behavioral;Blood Vessels;Brain;Brain Stem;Bypass;Chronic;Containment;Data;Diagnosis;Disease;Disease Progression;Dizziness;effective therapy;Environment;equilibration disorder;Equilibrium;Etiology;Exhibits;Eye Movements;Functional disorder;Goals;Head;Histologic;Histology;Histopathology;Human;human disease;human subject;Hyperbaric Oxygenation;Immune;Immune response;Immunosuppressive Agents;improved;Infection;innovation;Knowledge;Labyrinth;Labyrinthitis;Lassa Fever;Lassa virus;Light;Location;Maps;Mechanics;Mediating;Methods;Microscopy;Microtomy;Modality;Modeling;Molecular;mouse model;movement analysis;Mus;novel;Organ;otoconia;Outcome;Pathology;Performance;Phase;Phenotype;Population;prevent;Prevention;Procedures;Reflex action;response;Rotarod Performance Test;Sensorineural Hearing Loss;Sudden Hearing Loss;Survivors;Techniques;Testing;Time;Tissues;tool;Vestibular dysfunction;Vestibular inner ear;Vestibular Neuronitis;vestibular pathway;vestibular system;Viral Hemorrhagic Fevers;Virus;Virus Diseases

PROJECT_TITLE: Balance Dysfunction Induced by Lassa Virus Infection

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Genetics;Heart Disease;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE TANGO2 Deficiency Disorder (TDD) is a genetic condition associated with high mortality rates due to recalcitrant ventricular arrhythmias, unresponsive to standard antiarrhythmic therapy. Promising new data demonstrates B- vitamin supplementation can prevent and potentially treat arrhythmias in TDD, yet how B-vitamins impact the pathophysiology of TANGO2 Deficiency Disorder and the mechanism driving lethal ventricular arrhythmias remains unclear. This study proposes to assess B9, a component of B-vitamins, by combining clinical patient data, a mouse model, and patient-derived, induced pluripotent stem cells to investigate B9’s effectiveness in treating arrhythmias and to elucidate the mechanism of TDD-related arrhythmia development in this disease.

PI_NAMEs: MIYAKE, CHRISTINA YUMI (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Action Potentials;Acute;Animal Model;Animals;Anti-Arrhythmia Agents;Arrhythmia;Automobile Driving;autosome;Biological Models;Calcium;Cardiac;Cardiac Death;Cardiac Myocytes;Cell model;Cells;Child;Clinical;Clinical Data;clinically relevant;Cognitive;Data;Death Rate;Development;Diagnosis;Diet;Disease;Dose;drinking water;Effectiveness;Electrocardiogram;experience;Fasting;feeding;Folic Acid;folic acid supplementation;Functional disorder;Future;Gait;Genetic Diseases;Goals;Golgi Apparatus;Health;Heart;Heart Arrest;Heart failure;Homeostasis;Homologous Gene;Human;imaging study;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;infancy;Infusion procedures;insight;Intake;International;Interview;Investigation;Ion Channel;knock-down;Knockout Mice;Life;Maps;Metabolic;Modeling;mortality;mouse model;Mus;Mutation;Natural History;novel;Nutritional;Optics;Outcome;patch clamp;Patient Care;patient derived induced pluripotent stem cells;patient registry;Patients;Physicians;Predisposition;prevent;Prevention;Prospective Studies;protective effect;Proteins;Protocols documentation;Publishing;randomized, clinical trials;receptor;Recommendation;Recurrence;Regimen;Retrospective Studies;Role;Seizures;Speech;Supplementation;Telemetry;Testing;Therapeutic Intervention;Tissues;translational approach;translational study;unethical;uptake;Ventricular Arrhythmia;Ventricular Tachycardia;Vitamin B Complex;Vitamin B Deficiency;Vitamin Deficiency;Vitamins;Western Blotting;Work

PROJECT_TITLE: Investigation of Cardiac Arrhythmias in TANGO2 Disorder

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Nanotechnology

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative It is estimated that approximately 300 million people are infected with the hepatitis B virus (HBV), which is a largely incurable and lifelong infection that is responsible for >800,000 deaths annually, primarily due to severe symptoms including cirrhosis and liver cancer. Curative therapies for HBV are desperately needed but the lack of clinically relevant and affordable animal models for HBV have hindered the development of new therapies. In this proposal we will use our recently developed and affordable model for HBV to develop and evaluate novel curative gene therapies that target the HBV virus for elimination in infected cells.

PI_NAMEs: JEROME, KEITH R (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Affect;Animal Model;Animals;anti-hepatitis B;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Asian;Cells;Cessation of life;Chromatin;Chronic;Chronic Hepatitis B;Circular DNA;Cirrhosis;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complex;cost;COVID-19 vaccine;CRISPR/Cas technology;curative treatments;Data;delivery vehicle;Development;DNA;Dose;efficacy evaluation;efficacy testing;Enzymes;Evaluation;Event;experience;Gene Combinations;Gene Delivery;gene therapy;gene-editing approach;gene-targeted therapy;Genes;Genetic;Genome;genome integrity;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Genomics;genotoxicity;HBV Animal Model;Health;Hepatitis B;Hepatitis B Infection;Hepatitis B Virus;Hepatocyte;Hepatotoxicity;Human;humanized mouse;Immune response;Immunocompetent;immunogenicity;Immunotherapy;improved;In Vitro;in vivo;Infection;inhibitor;interest;lipid nanoparticle;Liver;Liver Failure;Longitudinal Studies;Malignant neoplasm of liver;Maximum Tolerated Dose;Mediating;Messenger RNA;Modeling;Monitor;mouse model;Mouse Strains;Mus;nanoparticle delivery;neurotoxicity;novel;novel strategies;novel therapeutics;nuclease;Persons;pgRNA;Pharmaceutical Preparations;Pongidae;Primary carcinoma of the liver cells;promoter;Publishing;Reporting;Reverse Transcriptase Inhibitors;Reverse Transcription;Risk;Safety;Simplexvirus;Study models;success;Symptoms;System;targeted nucleases;targeted treatment;Therapeutic;therapeutic development;therapeutic genome editing;Toxic effect;Transfection;Treatment Efficacy;Tupaiidae;Vaccines;vector;Viral;viral DNA;Viral Genes;Viremia;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: A new humanized mouse model to study HBV gene editing

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Pneumonia;Pneumonia and Influenza;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Having deciphered a clinical phenotype of impaired recovery in spinal cord injury (SCI) patients, we discover that a SCI-associated pneumonia (SCI-AP) induces propagated spinal injury manifesting as `infectious insult' – and with that, SCI-AP qualifies as causal, clinically relevant and targetable outcome-modifying factor causing injury/disrepair. Selecting a mechanistic approach supported by recent data from our lab, we will focus on one goal: Reveal novel targets to block or reverse SCI-AP-induced injury/disrepair. If successful, data from this grant proposal will inform the development of more effective non-antibiotic treatments for immune compromised SCI patients.

PI_NAMEs: SCHWAB, JAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;Acute Pneumonia;Adjuvant Therapy;Aging;Animals;antimicrobial;Applications Grants;Area;Axon;Bacteria;Bacterial Infections;Beds;Biological Assay;Blood;Blood capillaries;Blood Vessels;Cause of Death;Cells;Clinical;clinical phenotype;clinically relevant;comparison intervention;Contracts;Data;Deposition;Detection;Development;disability;Endothelium;Etiology;experimental study;feature detection;Functional disorder;Genetic Transcription;Goals;Hemorrhage;Hospitals;Hour;Immune;Immune Targeting;Immunity;immunogenic;Impairment;in vivo;Infection;Inflammatory;Injections;Injury;Innate Immune Response;insight;Interferon Type I;Interferons;Intervention;Iron;ITGAM gene;Knockout Mice;Label;Lesion;Letters;Localized Lesion;Locomotor Recovery;Macrophage;Mediating;Mediator;Medical;Microglia;Modeling;Molecular Target;monocyte;Mus;Myeloid Cells;nano;Nerve Degeneration;Nervous System Physiology;neuroinflammation;neurological recovery;Neurons;neuropathology;neuroprotection;neurotoxic;neurotoxicity;neurovascular;novel;novel strategies;Outcome;Parabiosis;pathogen;Pathologic;Pathology;Pathway interactions;Patients;Plasma;Pneumonia;Qualifying;Recovery;Recovery of Function;Risk;Role;Series;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Spinal;Spinal Cord;Spinal cord damage;Spinal cord injury;Spinal cord injury patients;Spinal Cord Lesions;Spinal Injections;Spinal Injuries;Streptococcus pneumoniae;targeted treatment;Testing;Three-Dimensional Imaging;Time;Tissues;Toxic effect;transcriptome;translational approach;treatment strategy;Viral;Virulent

PROJECT_TITLE: Protecting endogenous recovery from the "infectious insult" in Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Breast cancer is a leading cause of death in the U.S. and a major public health burden as one woman out of eight will receive a diagnosis in her lifetime. Large ‘omics’ studies that have been able to identify hundreds of breast cancer risk associated polymorphisms include women of mostly European ancestry even though preliminary evidence indicates that there is a clear benefit in studying genetically diverse samples. The goal of this study is to investigate the Latin American-specific genetic architecture of breast cancer overall and by distinct tumor subtypes, which are associated with differences in prognosis, and test predictive models that combine genetic and risk factor information accounting for variation by ancestry and geography.

PI_NAMEs: DUTIL, JULIE ;FEJERMAN, LAURA  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Accounting;Address;Awareness;Breast Cancer Genetics;breast cancer genomics;Breast Cancer Patient;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;California;Cancer Etiology;Cause of Death;Cessation of life;clinical practice;Complement;Complex;Country;Data;Diagnosis;Disease;disorder subtype;DNA;Environment;ESR1 gene;European;European ancestry;Foundations;Future;gene environment interaction;Genes;Genetic;genetic analysis;genetic architecture;genetic association;Genetic Polymorphism;Genetic Risk;Genetic study;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Geography;Germ Lines;Germ-Line Mutation;Goals;Heterogeneity;Hispanic;Hispanic Populations;improved;Indigenous American;Individual;Knowledge;Laboratories;Latin America;Latin American;Latina;Latina Population;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;Modification;molecular subtypes;neoplasm resource;non-genetic;novel;polygenic risk score;Population;predictive modeling;Prevention;Prognosis;prognostic;prognostication;protective allele;Public Health;Public Health Practice;Quantitative Trait Loci;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Marker;risk prediction;risk prediction model;risk stratification;risk variant;RNA Sequences;Sample Size;Sampling;Susceptibility Gene;Technology;Testing;Texas;Tissue Model;Tissues;tool;transcriptome;transcriptomics;translational study;tumor;Tumor Subtype;United States;Variant;Woman;Work

PROJECT_TITLE: Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Genetics;Nutrition;Obesity;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Mutations in a gene called Lamin A and C, or LMNA is the most common single gene problem causing human lipodystrophy, a human disease characterized by fat loss and problems in glucose and lipid metabolism. Despite being discovered as a cause of familial partial lipodystrophy in 2001, the exact mechanisms leading to fat loss in patients with LMNA mutations have remained elusive. In this proposal, we will systematically evaluate the potential mechanisms that may cause fat loss in this condition, making use of our novel animal models as well as tissue, cells, and nuclei obtained from affected human patients.

PI_NAMEs: MACDOUGALD, ORMOND A (contact);ORAL, ELIF ARIOGLU

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Adolescence;Adult;Affect;Animal Model;Architecture;autosome;Biology;Blood Glucose;Brown Fat;Caloric Restriction;Cell Nucleus;Cells;Cellularity;Cessation of life;Characteristics;Chromatin;Chromosome Structures;Clinical;Cultured Cells;Data;Defect;Deposition;Development;Diabetes Mellitus;Disease;Environmental Risk Factor;Exhibits;Familial partial lipodystrophy;Fasting;Fatty acid glycerol esters;Fatty Liver;gain of function;Gene Expression;Genes;genetic variant;glucose metabolism;High Fat Diet;Histologic;Hormones;Human;Human Characteristics;human disease;Hyperglycemia;Hyperinsulinism;Impairment;Inflammation;Inflammatory;insight;Insulin;Insulin Resistance;Knock-in;Knock-in Mouse;Knowledge;lamin C;Lamin Type A;Leptin;Life;lipid biosynthesis;lipid metabolism;Lipids;Lipodystrophy;Liver;loss of function;Maintenance;Metabolic;Metabolic dysfunction;Modeling;Molecular;Morphology;mouse model;multiple omics;Mus;Musculoskeletal;Mutation;novel;Nuclear;Nuclear Lamin;Nuclear Structure;Obesity;overexpression;Parents;Pathogenicity;Pathologic;Pathology;patient population;Patients;Phenotype;postnatal;premature;prevent;Proteomics;Puberty;recruit;Research;Testing;therapeutic target;Time;Tissues;transcription factor;transcriptome sequencing;Transgenic Mice;Variant

PROJECT_TITLE: Mechanisms of adipocyte loss in laminopathy-induced lipodystrophy in mice and humans

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Hematology;Precision Medicine

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Adjuvant strategies to thrombolytic therapy are needed for the 275,000 patients that develop chronic deep vein thrombosis each year. In this renewal project, we will extend our work that combines image-guided histotripsy with thrombolytic drugs to engineer new instrumentation for customizable treatment zones based on the target pathology, address safety concerns, and develop personalized treatment schemes that counter changes in the composition of thrombus with age. Successful completion of these tasks will enable us to bridge the current gaps that limit deployment of histotripsy as an adjuvant to thrombolytic therapy into the clinic.

PI_NAMEs: BADER, KENNETH B. (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Ablation;Acute;Address;Adjuvant;Affect;Age;aged;Algorithms;American;American Heart Association;Animals;Automobile Driving;Blood Circulation;Blood Platelets;Blood Vessels;Chronic;Clinic;Clinical;Clinical Trials;Coagulation Process;Combined Modality Therapy;Data;Deep Vein Thrombosis;design;Development;Disease;effective therapy;Electronics;Elements;Engineering;Ensure;Fibrinolysis;Fibrinolytic Agents;Fluoroscopy;Geometry;Health Care Costs;hemodynamics;Hemoglobin;Heterogeneity;Hour;Human;Image;image guided;imaging biomarker;imaging probe;improved outcome;In Vitro;in vivo;Individual;individualized medicine;instrumentation;Interventional radiology;Length;Liver neoplasms;Measurement;Mechanics;Microfluidics;Monitor;Outcome;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Physiologic pulse;Platelet Activation;porcine model;Protocols documentation;prototype;Public Health;Recommendation;research clinical testing;Resistance;Rupture;Safety;safety assessment;Saline;Scheme;single-cell RNA sequencing;Societies;Source;Specimen;standard of care;Structure;System;Techniques;Testing;Therapeutic Embolization;Thrombolytic Therapy;Thrombosis;thrombotic;Thrombus;Time;Tissues;Transducers;transmission process;Treatment outcome;Treatment Protocols;treatment strategy;Ultrasonic Therapy;Ultrasonography;Update;Veins;Venous;Venous Thrombosis;Work

PROJECT_TITLE: Treatment of chronic venous thrombosis with histotripsy and thrombolytics

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE  The goal of this research is to better understand the cellular mechanisms responsible for leaky blood vessels in the lung. While normally forming a tight barrier, during severe infections or inflammation the cells lining these vessels can form gaps which allow fluid to leak into the airspaces of the lung causing respiratory failure and often death, a process called acute respiratory distress syndrome (ARDS). By studying the underlying mechanisms and regulation of this process we hope to identify possible targets for treatment of this condition.

PI_NAMEs: BELVITCH, PATRICK  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Actins;Acute Lung Injury;Acute Respiratory Distress Syndrome;Air;Alveolar;Amino Acids;Area;Binding;Biochemical;Biological Assay;Blood capillaries;Blood Vessels;Caring;Cell Fractionation;Cell Line;Cell membrane;cell motility;Cell Shape;Cell Surface Extensions;Cells;Cessation of life;Clinical;clinically relevant;Code;Critical Illness;Cytoskeleton;Dextrans;Disease;Edema;Electrical Resistance;EMS1 gene;Endothelial Cells;Endothelium;Floods;Functional disorder;Future;Generations;Genes;Genetic;genetic regulatory protein;genetic risk factor;genetic variant;Goals;Human;Hypoxemia;Image;Imaging Techniques;Immunofluorescence Microscopy;Immunoprecipitation;improved;Individual;Infection;Inflammation;Inflammatory;inhibitor;Injury;insight;interstitial;Isoleucine;knock-down;Knockout Mice;Knowledge;Lentivirus Vector;Link;Liquid substance;Lung;lung injury;Maintenance;Measurement;Measures;Membrane;Microfilaments;migration;Modeling;Monomeric GTP-Binding Proteins;mortality;Mus;Myosin Light Chain Kinase;Myosin Type I;new therapeutic target;novel;Outcome;overexpression;Pathologic;Patients;Peripheral;Permeability;Plasma Cells;polymerization;Polymers;preclinical study;prevent;Process;protein complex;Proteins;Recovery;Regulation;Research;Respiratory Failure;Respiratory Mechanics;Risk;Role;Signaling Molecule;siRNA delivery;Small Interfering RNA;Structure;Valine;Variant;Work

PROJECT_TITLE: CARMIL1 and Endothelial Barrier Function Regulation

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Motor and non-motor impairments are linked to falls and a poor quality of life in individuals with Parkinson's Disease (PD). However, the underlying mechanisms remain poorly understood, limiting the avenues for treatment. This proposal will use mobile brain imaging to precisely measure brain activity during a laboratory- based balance assessment. We will identify individual variations in impaired brain function and their relationship to the poorly understood perceptual-motor and cognitive-motor impairments responsible for poor balance in PD. The technique has the potential to advance more personalized diagnosis and treatment to reduce falls for individuals living with PD.

PI_NAMEs: BORICH, MICHAEL ROBERT;TING, LENA H (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Agonist;antagonist;Anterior;Area;Attenuated;attenuation;balance recovery;Behavior;Biological Markers;Brain;brain dysfunction;Brain imaging;cingulate cortex;Clinical;Cognition;Cognitive;Complex;Data;density;Disabling;Discrimination;Dopamine;Electrocardiogram;Electroencephalography;Electrophysiology (science);equilibration disorder;Equilibrium;falls;Feedback;Functional disorder;Functional impairment;functional outcomes;Funding;Goals;heart function;Impairment;improved;Individual;Individual Differences;individual variation;innovation;insight;Intervention;Laboratories;Levodopa;Link;Measures;Mediating;millisecond;Mobility decline;Modeling;Motion Perception;Motor;motor impairment;Motor output;motor symptom;Movement;Muscle;neural circuit;neuroimaging;Neuromechanics;neuromechanism;non-motor symptom;older adult;Outcome;Parkinson Disease;Participant;Pattern;Perception;personalized diagnostics;personalized medicine;personalized strategies;Pharmaceutical Preparations;Postural response;Posture;precision medicine;predictive modeling;prospective;Quality of life;Recording of previous events;response;Scientific Advances and Accomplishments;sensory integration;Series;Source;spatiotemporal;Stress Tests;Surface;Symptoms;Task Performances;Techniques;Testing;Time;Trail Making Test;treadmill;Work;young adult

PROJECT_TITLE: Neuromechanical modeling of postural responses: Cortical mechanisms of balance impairments in Parkinson's disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cachexia;Cancer;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: The proposal aims to investigate the interaction between tumors and host organisms to find new methods of treating cancer in the context of a ketogenic diet (KD), because KD induced reduction of tumor growth but shorter overall survival in two mouse models of cancer cachexia associated with interleukin-6 (IL-6). The mechanism of cancer cell ferroptosis and the host's inability to synthesize corticosterone during metabolic stress will be studied in the context of NADPH depletion secondary to KD-induced lipid peroxidation. The role of IL-6-induced anorexia and growth differentiation factor-15 (GDF-15)-induced anorexia as contributors to cachexia will also be examined, with the latter being elevated by oxidative stress in a KD.

PI_NAMEs: JANOWITZ, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 4 hydroxynonenal;Acceleration;adduct;Adrenal Glands;Anabolism;Anorexia;anti-cancer;Appetite Depressants;Area;Bilateral;Binding;Biochemical;Biological Assay;Biology;blood glucose regulation;Brain;Cachexia;Cancer Cachexia;cancer cell;cancer therapy;carcinogenesis;Cell Line;Cellular Stress;Cessation of life;Clinical Research;Clinical Trials;Colorectal Cancer;Combined Modality Therapy;Compensation;Complex;Corticosterone;Deceleration;Dependovirus;Detoxification Process;Development;Diet;Dietary Intervention;early onset;Eating;energy balance;Engineering;experimental study;Failure;feeding;Female;Food;FOS gene;GDF15 gene;Generations;Glucocorticoids;Glutathione;Goals;Growth;histological slides;Immunity;Impairment;Implant;improved;Injections;interest;Interleukin-6;ketogenesis;ketogenic diet;Knock-out;KPC model;Licensing;Light;Lipid Peroxidation;Lipid Peroxides;Lipids;Liver;male;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Medical;Medicine;Metabolic;Metabolic stress;Metabolism;metabolomics;Methods;morphogens;mouse model;Mus;NADP;neuronal circuitry;neuronal patterning;Neurons;novel therapeutic intervention;Nutrient;Nutritional;Organism;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;pancreatic cancer model;parabrachial nucleus;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phase I/II Clinical Trial;Physiologic pulse;Plasma;polyunsaturated fat;Polyunsaturated Fatty Acids;Population;preclinical study;Production;programs;receptor;receptor expression;Reduced Glutathione;Research;Role;Scientist;Secondary to;sex;Signal Transduction;Stains;Steroids;Structure of area postrema;System;Testing;Tetanus Toxin;Therapeutic;Tissues;transcriptomics;treatment strategy;tumor;tumor growth;tumor progression;Tumor Volume;Unsaturated Fatty Acids;Up-Regulation;Wasting Syndrome;Work

PROJECT_TITLE: Mechanism by which ketogenic diet uncouples tumor growth and overall survival

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our incredibly diverse cell types are all produced from a single genome template, and it is thought that the three dimensional packaging of the genome within the nucleus determines cell type specific gene function. Here we use the fruit fly model to understand how the neural progenitor genome organized the mechanisms by which this organization changes over time to regulate genes in the neurons. Results will provide new insights into a fundamental question on how different neural identities are generated during development.

PI_NAMEs: KOHWI, MINOREE  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Address;Animals;Applications Grants;Architecture;Binding;Biological;Biological Models;Birth Order;Brain;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Competence;Data;Development;Developmental Biology;Distal;Drosophila genus;Elements;Embryo;Embryonic Development;Event;fly;Gene Expression;gene function;gene interaction;Gene Order;gene repression;Genes;Genetic Transcription;Genome;genome-wide;genomic data;genomic profiling;Genomics;Grant;Heritability;Heterogeneity;High-Throughput Nucleotide Sequencing;in vivo;insight;Introns;Knowledge;Lamins;Liquid substance;Maintenance;Mammals;Maps;Mediating;Modeling;Molecular;mutant;nerve stem cell;neural;neuroblast;neurodevelopment;Neurons;novel;Nuclear;Nuclear Lamina;Nuclear Protein;Organizational Change;Phase;Physical condensation;Play;Polycomb;Population;Production;progenitor;programs;Property;Refractory;Regulation;Regulator Genes;Regulatory Element;Role;Specific qualifier value;stem cell function;Stereotyping;Structure;System;Testing;Time;Tissues;Trans-Activators;transcriptome sequencing;Validation

PROJECT_TITLE: Chromatin factor regulation of neuroblast progenitor genome dynamics

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: This proposal will focus on enrollment and follow up of participants in the NAFLD Database 3 (DB3) study and the VEDS clinical trial of the NIDDK NASH CRN and to perform ancillary studies leveraging these data- sets, with to obtain novel insights in to disease heterogeneity and transcriptomic drivers of disease progression.

PI_NAMEs: SANYAL, ARUN J (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acceleration;Address;Adult;age acceleration;Ancillary Study;Biological Markers;Biology;biomarker validation;Childhood;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;clinically significant;cohort;Cohort Studies;Collaborations;Collection;Data;data integration;data resource;Data Set;Databases;Development;Disease;disease heterogeneity;disease model;Disease Outcome;Disease Progression;Dose;economic determinant;effective therapy;Enrollment;Evolution;fibrogenesis;Fibrosis;follow-up;Funding;Future;Genes;Goals;health determinants;Health Services Accessibility;Histologic;improved;Individual;Inflammation;insight;Knowledge;Laboratories;Lead;Link;Liver;Liver diseases;Measurement;metabolic abnormality assessment;Metabolic dysfunction;metabolomics;Mission;Molecular;Morbidity - disease rate;mortality;Names;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Organ;Outcome;Outcome Assessment;Participant;Pathway interactions;Patients;personalized approach;Pharmaceutical Preparations;Play;Population;prospective;Proteomics;Protocols documentation;Publications;Publishing;Qualifying;recruit;Registries;Research Personnel;Resource-limited setting;Resources;response;retention rate;Role;Severities;Site;social determinants;Spleen;Steatohepatitis;Testing;therapeutic development;therapeutically effective;Time;transcriptomics;translational study;Universities;Validation;Virginia;Vitamin E;Work

PROJECT_TITLE: Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative. While the components of key morphogen signaling pathways have been identified, a systems-level understanding of how signaling activity propagates and creates fate patterns is lacking. Here we take advantage of novel live cell reporters and human stem cell-based patterning systems to combine quantitative experiments with mathematical modeling to understand how the paradigmatic Nodal/Lefty pathway shapes cells fates in the early embryo. The results will be fundamental to understanding early embryonic development and provide a foundation for advances in preventing birth defects and in regenerative medicine.

PI_NAMEs: WARMFLASH, ARYEH  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adopted;Affect;Attention;autocrine;Cell Line;Cell Physiology;Cell Shape;Cells;CFC1 gene;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Congenital Abnormality;Data;Defect;Development;Embryo;Embryonic Development;Epiblast;Experimental Models;experimental study;extracellular;Extracellular Protein;Family member;Feedback;Foundations;gain of function;Genes;Genetic Transcription;Germ Layers;Human;human pluripotent stem cell;human stem cells;Image;inhibitor;interest;Left;Ligands;loss of function;Mammals;Maps;mathematical model;Measures;Modeling;morphogens;Nodal;nodal protein;novel;overexpression;Pathway interactions;Pattern;Play;prevent;Proteins;Radial;receptor;receptor function;Regenerative Medicine;regenerative tissue;Reporter;Role;self organization;Shapes;Signal Pathway;Signal Transduction;Spatial Distribution;Specific qualifier value;System;Time;Tissue Model;tool;Transducers;Transforming Growth Factor beta;Visualization;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Visualization of extracellular morphogens to understand self-organized patterning


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PHR: Project Narrative The core signaling mechanisms that regulate basic cellular functions, such as cell division, metabolic homeostasis, and subcellular structural organization, tend to be highly conserved in all eukaryotes, whereas diverse mechanisms of intercellular communication have evolved to support different morphologies and lifestyles of different organisms. Investigation of signaling mechanisms in plant model systems is not only important for agriculture, food security, and ecosystem sustainability but also can inform medical research because many plant signaling components are conserved in humans and Apicomplexa which includes parasites responsible for serious human diseases, such as malaria and toxoplasmosis.

PI_NAMEs: WANG, ZHIYONG  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acclimatization;Affect;Agriculture;Animals;Apicomplexa;Arabidopsis;Biochemical;Biological;Biological Models;Carbon;Cell Communication;Cell Cycle;Cell Cycle Regulation;Cell division;Cell model;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Chemicals;Chlamydomonas;Complex;Cues;Cytokinesis;Development;developmental plasticity;drug development;Ecosystem;environmental adaptation;Eukaryota;Evolution;food security;Food Supply;Fucose;Gene Expression;Genetic;Genomics;glycosylation;Goals;Grant;Growth;Growth and Development function;Health;Homeostasis;Hormonal;Hormones;Human;human disease;Immune response;Immune signaling;Immunity;immunoregulation;improved;insight;Instruction;intercellular communication;Investigation;Label;Life Style;Link;Malaria;Maps;Mass Spectrum Analysis;Mediating;Medical Research;Meristem;Metabolic;Metabolism;Mitosis;Molecular;Morphogenesis;Morphology;Natural Immunity;Nutrient;organ growth;Organism;Parasites;Pathway interactions;Pattern;Personal Satisfaction;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;plant growth/development;Plant Model;Plants;Play;Post-Translational Protein Processing;Productivity;promote resilience;protein protein interaction;Proteins;Proteomics;receptor;Regulation;Research;Research Project Grants;Research Support;resilience;Resource Allocation;response;Role;Signal Pathway;Signal Transduction;Steroids;Stimulus;Stomas;structural biology;sugar;Sustainable Development;System;Technology;Toxoplasma;Toxoplasmosis;trafficking;Vascular Plant;Vesicle

PROJECT_TITLE: Genetic Biochemical Studies of Signaling in Growth and Acclimation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE During the previous grant period, we discovered how the human pathogen enterohemorrhagic Escherichia coli responds to mechanical cues in its environment by subcellular compartmentalisation of the transcriptional regulator GrlA, and showed the mechanistic basis of GrlA shuttling between inner membrane and cytoplasm in resting versus mechanically stimulated cells. The experiments described in this application will determine how another key EHEC virulence factor, Shiga toxin, is regulated by mechanical cues, and how the toxin facilitates EHEC colonization by modulating gut motility and displacement of the endogenous microbiota. This work will reveal a new regulatory mechanism for Shiga toxin-converting phage, and provide new insights as to the role of the toxin during host colonization.

PI_NAMEs: KRACHLER, ANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acceleration;Adhesions;Affect;Bacteria;Bacterial Genes;Bacteriophages;Binding;Biochemical;blind;Cells;Chemicals;Clinical;Cues;Cytoplasm;Diarrhea;Dissociation;Enteric Nervous System;Enterocolitis;Enterocytes;Environment;Escherichia coli EHEC;Escherichia coli Infections;experimental study;Feedback;fitness;fluid flow;Gastrointestinal Motility;Gene Expression;gene induction;Genetic Transcription;Goals;Grant;gut microbiota;Hemolytic-Uremic Syndrome;host colonization;Human;human pathogen;imaging approach;in vivo;Infection;Ingestion;insight;Interphase Cell;Intestinal Motility;Intestines;Knowledge;Life Style;Liquid substance;Lytic;mechanical force;mechanical properties;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Mediating;member;Membrane;microbial;Microbial Biofilms;Microbiology;microbiota;Modeling;Molecular;Motility;novel;Organism;pathogenic bacteria;Pathogenicity Island;Pathway interactions;Phenotype;Physiology;Play;pressure;Production;Regulation;Regulatory Pathway;Research;response;Rest;Role;shear stress;Shiga Toxin;Shiga-Like Toxin II;SOS Response;Stimulus;Surface;System;Testing;Time;Toxin;Transcript;Transcription Coactivator;transmission process;Type III Secretion System Pathway;Variant;Virulence;Virulence Factors;virulence gene;Vomiting;Work;Zebrafish

PROJECT_TITLE: Mechanoregulation of EHEC virulence

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Proper synthesis, folding, modification, assembly, and quality control of collagen, the most abundant protein in the human body, is essential for the structure and function of diverse tissues, including bone, skin, cartilage, tendon, and more. Defects in collagen production underlie diverse, currently incurable diseases. This proposal (1) uses a comprehensive suite of in vitro and in vivo approaches to elucidate molecular mechanisms of collagen production, both how they work well and how they go awry, and (2) tests new, small molecule- based strategies for ameliorating disease-causing collagen proteostasis defects in state-of-the-art 3D tissue model systems, culminating in advances in fundamental understanding and new therapeutic approaches for the collagenopathies.

PI_NAMEs: SHOULDERS, MATTHEW DONALD (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animals;Attention;autosome;Basement membrane;Biochemical;Biochemistry;Biological Models;bone;Cartilage;Cells;Chemicals;Chronic stress;Clinical;Collagen;Collagen Diseases;Cystic Fibrosis;Data;Defect;Deposition;Disease;effective therapy;Endoplasmic Reticulum;expectation;Extracellular Matrix;Face;Failure;Foundations;Functional disorder;fundamental research;Funding;Genes;Genetic;Genetic Diseases;Health;Human;Human body;In Vitro;in vivo;Intervention;Knowledge;Lead;Lectin;Life;malformation;Missense Mutation;Modality;Modeling;Modification;Molecular;Molecular Chaperones;Mutation;Nature;Normal tissue morphology;novel therapeutic intervention;Other Genetics;palliative;Palliative Care;Pathologic;Pathway interactions;pharmacologic;Phenotype;Play;Polysaccharides;pre-clinical;Preclinical Testing;Process;Procollagen;Production;Property;protein aggregation;protein misfolding;Proteins;proteostasis;proteostasis loss;Quality Control;regenerative;Research;scaffold;screening;Skin;small molecule;Structure;Symptoms;System;targeted treatment;Tendon structure;Testing;Therapeutic;Tissue Model;Tissues;triple helix;Work

PROJECT_TITLE: Collagen Proteostasis in Health and Disease

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The prevalence of alcohol-associated liver disease (ALD) is increasing with little advancement in treatment options for patients besides transplantation for end-stage disease. Our lab has identified that macrophage migration inhibitory factor (Mif) is a critical contributor to ALD pathophysiology. The current proposal will define the tissue-specific roles of the Mif receptor Cd74 in ALD progression and create novel interference therapeutics against this inflammatory axis in ALD.

PI_NAMEs: POULSEN, KYLE  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;alcohol exposure;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Anti-Cytokine Therapy;Antisense Oligonucleotides;Area;Carbon Tetrachloride;Cell Death;Cells;Cellular Stress;Cessation of life;Chemosensitization;chronic liver disease;Cirrhosis;Complex;Custom;Data;defined contribution;design;Disease;Disease Progression;end stage disease;Epithelium;Ethanol;experience;Experimental Models;feeding;Fibrosis;Functional disorder;Funding;Gene Expression;Genetic Models;Glucocorticoids;Goals;Hepatic;Hepatitis;Hepatocyte;Human;Immune;improved;in vivo;Incidence;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Injury;Innate Immune Response;Knock-out;Laboratories;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver metabolism;liver transplantation;Macrophage;Measures;Mediating;Mediator;Migration Inhibitory Factor;Mitochondria;Modeling;Modification;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;novel;Pathway interactions;Patients;Phenotype;Play;Population;Prevalence;Primary carcinoma of the liver cells;programs;Publications;receptor;Research;Role;Signal Transduction;single-cell RNA sequencing;Source;Specificity;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tissue injury;Tissues;tool;trafficking;transcriptomics;Transplantation;Up-Regulation;Work

PROJECT_TITLE: Receptor Cd74 integrates meta-inflammation in alcohol-associated liver disease

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Sleep Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite apparently normal nighttime sleep. Diagnosis and treatment of IH are impeded by limited understanding of disease etiology. This proposal seeks to generate new insights into molecular and genetic mechanisms of hypersomnia using a cross-species approach informed by human genetics and genomics.

PI_NAMEs: CHESI, ALESSANDRA  (contact);KAYSER, MATTHEW S

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Arousal;Astrocytes;ATAC-seq;Back;behavior test;Behavioral;Biological;Biological Process;Brain;Candidate Disease Gene;candidate identification;candidate validation;causal variant;Cell Adhesion Molecules;cell type;Cells;Chromatin;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Data Set;Development;Diagnosis;Disease;Drosophila genus;Drosophila melanogaster;Drowsiness;Etiology;Excessive Daytime Sleepiness;Family history of;fly;gene discovery;Genes;Genetic;genetic manipulation;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genomic approach;genomic locus;Genomics;Goals;Heritability;Hi-C;Homologous Gene;Human Genetics;Human Genome;human genomics;human induced pluripotent stem cells;Hypersomnias;Idiopathic Hypersomnolence;imaging approach;Impaired cognition;Impairment;in vivo;induced pluripotent stem cell;insight;knock-down;Knock-out;knockout gene;Light;Link;Linkage Disequilibrium;loss of function;Maps;Methods;Modeling;Molecular;Morphology;Napping;Narcolepsy;Neurons;neuropeptide F;novel;novel strategies;Orthologous Gene;Pathway interactions;Patients;Phenotype;Population;Prevalence;Prevention;promoter;Quality of life;Regulatory Element;Reporting;Resolution;RNA Interference;Sentinel;Signal Transduction;Sleep;symptom management;Synapses;System;Testing;trait;Translations;Twin Multiple Birth;Twin Studies;Validation;Variant;Work;Zebrafish

PROJECT_TITLE: A cross-species approach to hypersomnia genetics informed by human GWAS

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Urinary tract infections (UTIs) are a major driver for antibiotic prescriptions worldwide, with Pseudomonas aeruginosa causing approximately three million infections a year, primarily in older individuals. While this number matches the number of wound and respiratory infections caused by the pathogen, there is very limited investigation on how Pseudomonas establishes infection in the urinary tract. In this work, we propose to leverage our recently collected uropathogenic Pseudomonas isolates – which differ genomically from strains that cause respiratory or wound infections – to determine the pathogenic cascade of Pseudomonas in the bladder and to elucidate how age may influence the ability of this pathogen to persist.

PI_NAMEs: HADJIFRANGISKOU, MARIA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: acute infection;Age;age effect;age related;aged;Aging;aging population;Anabolism;Antibiotics;Automobile Driving;Biology;Bladder;Bladder Tissue;C3H/HeN Mouse;Cells;cohort;Collaborations;Complex;Cystitis;cytokine;Cytosol;Data;Development;diagnostic tool;Elderly;Electrons;emerging pathogen;Energy Metabolism;Environment;Epithelial Cells;Epithelium;Escherichia coli;experimental study;Female;Genome;Genomics;Health;Human;Hypoxia;Immune;Immune response;In Vitro;in vivo;Infection;Infection Control;innovation;insight;Integration Host Factors;Invaded;Investigation;Kinetics;Klebsiella;Lung;Lung infections;male;Measures;Metabolism;Methodology;Microbial Biofilms;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;old mice;Older Population;Oxidation-Reduction;Oxygen Consumption;pathogen;pathogen genomics;Pathogenesis;Pathogenicity;Patients;Pigments;Population;prevent;priority pathogen;Production;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas Infections;Pyocyanine;Research;Respiration;respiratory;Respiratory Chain;Respiratory physiology;Respiratory Tract Infections;Series;Study models;Testing;Time;tissue culture;tissue/cell culture;tool;Tropism;Urinary tract;Urinary tract infection;Urine;Urologic Diseases;Uropathogen;Urothelial Cell;Variant;Work;World Health Organization;wound;Wound Infection

PROJECT_TITLE: Pseudomonas pathogenesis in the bladder


NIH_SPENDING_CATS: Kidney Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Our preliminary data identified potassium dysregulation with YAP silencing and KCa3.1 (intermediate- conductance calcium-activated potassium channel) as a key regulator of podocyte survival and a potential therapeutic target in progressive glomerular disease. The proposed research will advance the currently available knowledge of glomerular disease pathogenesis and serve as a platform for developing a novel therapeutic strategy for proteinuric kidney disease.

PI_NAMEs: CAMPBELL, KIRK N (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Actins;Acute;Albuminuria;Architecture;Biopsy;Calcium Signaling;Calcium-Activated Potassium Channel;Cell Differentiation process;Cellular Morphology;chromatin immunoprecipitation;clinical development;clinically relevant;Complex;Cytoplasm;Cytoskeleton;Data;Disease;disease model;Disease Progression;efficacy testing;Focal Adhesions;Focal and Segmental Glomerulosclerosis;Gene Expression;Genes;glomerular filtration;Goals;Health;Homeostasis;Human;in vivo;in vivo evaluation;in vivo Model;inhibitor;Injury;Kidney;Kidney Diseases;knock-down;Knowledge;Left;Mediating;Modeling;Molecular;Mus;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Ontology;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Chemistry;pharmacologic;Phosphorylation;Phosphotransferases;podocyte;Potassium;Potassium Channel;Predisposition;protein expression;Purinoceptor;rational design;Regulation;Renal glomerular disease;Repression;Research;Role;Signal Pathway;Signal Transduction;Site;Testing;therapeutic development;therapeutic target;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Hippo-YAP in podocyte health and disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: NARRATIVE Animals exhibit a suite of behavioral changes known as sickness behaviors during infectious conditions. The purpose of this application is to elucidate the neural circuits in the brain impacted by sickness to alter behaviors. Successful completion of this application will provide new insights into the neuroimmune interactions adopted by animals to cope with infection and how such a strategy, when dysregulated, can potentially lead to neurological disorders whose causes are rooted in immune activation.

PI_NAMEs: CHOI, GLORIA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adaptive Behaviors;Adopted;Affect;Anatomy;Animal Behavior;Animals;antagonist;Automobile Driving;Behavior;Behavioral;Binding;Blood - brain barrier anatomy;Brain;Brain region;cell type;Cells;Central Nervous System;Communities;coping;cytokine;Cytokine Receptors;Data;Disease;dorsal raphe nucleus;Exhibits;feeding;Feeding behaviors;Food;Generations;Genetic;IL1R1 gene;Immune;immune activation;Immune response;Immune system;in vivo;Infection;Inflammation;Inflammatory;insight;Interleukin-1 beta;Interleukin-1 Receptors;Knock-in Mouse;Knowledge;Literature;Locomotion;Maps;Mediating;Methods;Modification;Molecular;Monitor;Motivation;Nervous System;Nervous System Disorder;neural;neural circuit;Neuroimmune;neuromechanism;Neuromodulator;neuronal circuitry;Neurons;Neurosciences;novel therapeutics;Nutrient;Nutrient availability;pathogen;Pathogenicity;Peripheral;Permeability;Physical activity;Play;Population;Proteins;receptor;receptor expression;Regulation;Research;response;Rest;Role;Sensory;Signal Pathway;Signaling Molecule;social;Social Interaction;Social isolation;System;Testing;Visualization

PROJECT_TITLE: Elucidating neural mechanisms underlying sickness behaviors


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: NARRATIVE This project is to assess the impact of urban greenspaces on community health. For this assessment, we acquired health data from individuals living in a low-to-middle income neighborhoods in Louisville, KY before and after planting a large number of mature trees and shrubs in the area. We have also acquired data on air pollution, before and after the planting. We now plan to study the long-term impact of this intervention on community health and the levels of air pollution in the neighborhoods.

PI_NAMEs: BHATNAGAR, ARUNI  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Air Pollutants;Air Pollution;Ancillary Study;Area;arterial stiffness;Biological Markers;Biomass;Blood;cardiovascular disorder risk;cardiovascular health;Characteristics;climate change;Clinical Data;Clinical Trials;cohort;Communities;community engagement;Community Health;Cost-Benefit Analysis;criteria air pollutant;Data;Data Set;Databases;Development;Ecosystem;efficacy trial;Ensure;Environment;Environmental Exposure;Environmental Impact;environmental intervention;epidemiologic data;Evaluation;evidence base;Exposure to;follow-up;Follow-Up Studies;foot;Green space;Hair;Health;health assessment;health data;Health Policy;Health Promotion;Heart;Human;Imagery;Immunity;implementation facilitators;Income;Individual;insight;Interruption;Intervention;intervention effect;Link;Long-Term Effects;Longitudinal Studies;Maps;Measures;member;Monitor;Nature;Neighborhoods;Noise;Observational Study;Outcome;Ozone;Persons;Phase;Physiological Processes;Plants;Pollution;Population;psychologic;psychosocial;Public Health;Questionnaires;racial diversity;Research Design;Resolution;Sampling;Scanning;secondary analysis;Selection Criteria;Series;Services;social;Stress;systemic inflammatory response;Temperature;Testing;Time;Trees;ultrafine particle;Urine;volatile organic compound;Work

PROJECT_TITLE: Urban Greenness and Cardiovascular Health

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful skin alterations in the skin-fold areas leading to low quality of life, with racial and sex disparities. However, the pathogenesis of HS and contributing factors to the disease disparities are poorly understood. The overall goal of this project is to define the genetic contributors to HS risk using whole-genome sequencing and functional genomics, which may uncover the pathogenesis of HS, leading to new therapeutic targets and treatments for HS patients.

PI_NAMEs: ADRIANTO, INDRA ;MI, QING-SHENG  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Abscess;admixture mapping;Affect;African American;African American population;American;Area;Autoimmune Diseases;Black race;Blood;Blood Cells;Caring;cell type;Cells;Chronic;Chronic Disease;chronic inflammatory skin;Cicatrix;cohort;comorbidity;Cytometry;Data;Data Set;Dermatologic;Development;differential expression;disease disparity;Disease remission;Disparity;ethnic difference;Ethnic Origin;Ethnic Population;experience;Female;functional genomics;Gene Expression;General Population;Genes;Genetic;genetic resource;Genetic Risk;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide;genomic locus;Germ Lines;Goals;Hair follicle structure;Health;Hidradenitis Suppurativa;Hispanic;Immune;Immunologist;improved;Individual;Inflammation;Inflammatory;insight;Knowledge;Latino;Latino Population;Link;male;Maps;Membrane Proteins;Meta-Analysis;Molecular Target;monocyte;multi-racial;multiple omics;new therapeutic target;Nodule;Pain;Pathogenesis;Patients;Phase;Plasma;Plasma Proteins;Population;Predisposition;Prevalence;Procedures;protein expression;Proteins;Proteome;Proteomics;psychologic;Publishing;Quality of life;Quantitative Trait Loci;Race;racial difference;racial disparity;racial diversity;racial population;rare variant;Recurrence;Research;Risk;risk variant;Sample Size;Severities;Severity of illness;sex;Sex Differences;sex disparity;single-cell RNA sequencing;Sinus;Site;Skin;skin disorder;Testing;therapeutic development;Therapeutic Intervention;Time;Validation;Variant;whole genome

PROJECT_TITLE: Whole genome sequencing analysis of hidradenitis suppurativa

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Heart Disease;Hematology;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: NARRATIVE Tissue factor pathway inhibitor (TFPI) is a protein that prevents blood from clotting. This proposal will examine basic biochemical interactions between TFPI, other blood clotting proteins, and proteins in the extracellular matrix and how these interactions modulate disease development in animal model systems. The results will be important for developing new treatments for thrombotic and bleeding diseases.

PI_NAMEs: MAST, ALAN E (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Adult;Affect;Affinity;angiogenesis;Animal Model;Anticoagulants;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Biological Process;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Brain Pathology;C-terminal;Cardiac;cerebrovascular;Coagulation Process;Collagen;Collagen Type VI;Complex;coronary fibrosis;Data;Defect;Development;Disease;Echocardiography;Embryo;Embryonic Development;Endothelial Cells;Endothelial Growth Factors;Endothelium;Estrogens;experimental study;Extracellular Matrix;factor V Leiden;feeding;Fertility Agents;Fetal Development;Fibrosis;Functional disorder;Funding;Generations;Growth Factor;Heart;heart function;Hemorrhage;Hemostatic function;Heparin;Histology;Human;human disease;In Situ;Infiltration;inhibitor;innovation;irradiation;Kinetics;Knockout Mice;Laboratories;Labyrinth;Location;Measurement;Measures;Mediating;Metalloproteases;Modeling;mouse model;Mus;novel therapeutic intervention;Oral Contraceptives;PGF gene;Physiological;Placenta;Placentation;Plasma;Platelet Activation;pregnant;prevent;Process;Production;Protein Isoforms;Proteins;Publishing;response;Role;Signal Pathway;Signal Transduction;Spontaneous abortion;Surface;TFPI;Thrombin;Thromboplastin;Thrombosis;thrombotic;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transplantation;Variant;Vascular Diseases;Vascular Endothelial Growth Factors;vascular injury;Woman

PROJECT_TITLE: Characterization of an isoform specific anticoagulant function of TFPI-alpha

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Aging;Kidney Disease;Prevention

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: The proposed studies will determine if the nuclear hormone receptors which are highly expressed and regulated in the kidney, the estrogen related receptors (ERRs), play an important role in treating and preventing age- related kidney disease. We propose that: (1) decreased expression of ERRα or ERRγ accelerates age-related kidney diseases, whereas increased expression of ERRα or ERRγ slows age-related kidney disease (Specific Aim 1); (2) ERRs modulate age-related kidney disease by inhibiting the increased synthesis and accumulation of ceramides and glycosphingolipids (Specific Aim 2); (3) ERRs modulate age-related kidney disease by inhibiting proinflammatory immune cells (Specific Aim 3).

PI_NAMEs: LEVI, MOSHE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Adult;Age;age acceleration;age related;Age related comorbidities;age related decline;Aging;Agonist;Albumins;Caloric Restriction;CCL2 gene;Cells;Ceramide glucosyltransferase;Ceramides;Chronic Kidney Failure;Crossbreeding;dihydroceramide desaturase;Elderly;ERR1 protein;Estrogen Therapy;estrogen-related receptor;Excretory function;Glucosylceramides;Glycosphingolipids;Health;human old age (65+);Hypertension;Immune;immunoregulation;Impairment;Individual;Inflammation;Inflammatory;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Knowledge;LCN2 gene;lipidomics;Lipids;LoxP-flanked allele;Mass Spectrum Analysis;Measures;Metabolic syndrome;Microscopy;mimetics;Mitochondria;Mus;novel;NPHS2 protein;Nuclear Hormone Receptors;old mice;overexpression;Pathology;Play;podocyte;Population;Populations at Risk;prevent;Prevention strategy;receptor;Regulation;Renal function;Renal tubule structure;Resolution;Role;spectroscopic imaging;Sphingolipids;Sphingomyelins;Testing;treatment strategy;Tubular formation;urinary

PROJECT_TITLE: Role of Estrogen Related Receptors in Age Related Kidney Disease


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis

PHR: The most basic function of skin is to protect tissue from the environment. This protection is due to a permeability barrier that is critically dependent on a type of fatty substance called ceramide. Many skin diseases are due to a loss of ceramide. This project is to discover how the correct kinds of ceramides are made to maintain skin barrier function.

PI_NAMEs: COWART, LAUREN ASHLEY;PALLER, AMY S;WATTENBERG, BRIAN W. (contact)

PROJECT_TITLE: Sphingolipid Biosynthesis in the Healthy and Diseased Epidermal Barrier


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This proposal is relevant to US public health since cancer remains the leading cause of disease related death in childhood in the US. In addition, while approximately 80% of patients diagnosed with cancer today will be cured of their original disease, few of these survivors will have a normal lifespan and most will experience secondary diseases and disabilities as a result of the toxic cancer therapies they receive. The proposed research is highly relevant to the NIH mission, as it seeks to discover new scientific principles and develop new immunotherapies for the treatment of children’s cancers, which will also provide generalizable knowledge regarding optimal approaches to develop immunotherapies for low mutational burden cancers occurring in other populations.

PI_NAMEs: MACKALL, CRYSTAL  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Area;base editing;Biology;Cancer Burden;Cancer Center;cancer therapy;Cell Therapy;cellular engineering;Cellular Immunology;Cessation of life;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Country;CRISPR screen;cytotoxic;design;Diagnosis;disability;Disease;Ecosystem;Engineering;experience;Gene Delivery;Immune Evasion;immune resistance;immunoengineering;Immunotherapy;improved;in vivo;Income;Infrastructure;knockout gene;Knowledge;Laboratories;Late Effects;life span;Malignant Childhood Neoplasm;Malignant Neoplasms;manufacture;Mission;Molecular Immunology;Mutagenesis;Mutation;next generation;novel strategies;Patients;Pediatric Oncology;Pharmaceutical Preparations;Population;programs;Property;Protein Engineering;protein expression;Proteins;Public Health;Quality of life;Regimen;Research;RNA;Safety;Second Primary Neoplasms;standard care;Survivors;synthetic biology;synthetic protein;T-Lymphocyte;targeted treatment;Technology;Therapeutic;therapeutic development;Toxic effect;Translations;tumor microenvironment;United States National Institutes of Health;Universities;Viral;Work;Yeasts

PROJECT_TITLE: Next Generation Immunotherapies for Pediatric Cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Services;Human Genome

PHR: Translating genomic discoveries into clinical practice is vital but riddled with challenges - slow adoption of guidelines, lack of diversity in studies, inadequate reimbursement policies, and more. By integrating world-class scientific expertise in genomics with success in learning healthcare system implementation and internationally recognized high quality coordination capability, Vanderbilt University Medical Center (VUMC) will create a unified, genomics-enabled, learning healthcare system (gLHS) Network. We will facilitate project selection and optimization, establish a shared technical gLHS architecture, adapt and tailor to meet various local contexts, and build trust through authentic partner engagement enabling the next frontier in precision medicine by making genomics a more readily accessible component of routine care.

PI_NAMEs: AUDET, CAROLYN ;PETERSON, JOSEPH F. (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Academic Medical Centers;Accountability;Adopted;Adoption;adverse drug reaction;Affect;Architecture;barrier to care;Caring;Clinical;Clinical Informatics;clinical practice;clinical research site;cohesion;Collaborations;Communication;Communities;Community of Practice;Complex;cost;Data;Data Collection;data exchange;data modeling;Dedications;design;Diagnostic;empowerment;Enrollment;Ensure;Environment;Evaluation;Event;evidence base;Evolution;experience;Family;flexibility;Fostering;frontier;Generations;Genetic Risk;genetic testing;Genome;Genomic medicine;Genomics;Goals;Guidelines;Health;health care availability;Health system;Healthcare;Healthcare Systems;Home;Human;Human Genome;implementation facilitation;implementation tool;improved;Informatics;Infrastructure;innovation;International;interoperability;Intervention;intervention refinement;Knowledge;Laboratories;Learning;Maps;Measures;Medical center;Medicine;Methodology;Methods;Modification;Molecular;Monitor;National Human Genome Research Institute;operation;Outcome;Outcome Measure;Patient Care;Patients;phenome;Policies;Practice Guidelines;precision medicine;prevent;Procedures;programs;protocol development;Protocols documentation;Provider;Randomized, Controlled Trials;Reporting;Research;Research Design;Resources;Role;routine care;Security;Serious Adverse Event;Site;Standardization;success;successful intervention;support network;Surveys;system architecture;Testing;Training;Translating;translational genomics;Trust;Variant;Work;Writing

PROJECT_TITLE: Coordination for Demonstrating Real-world Advancement in Genomics Operations Network (DRAGON)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative: Liver fibrosis is a major health concern. We will develop rapid and inexpensive paper-based diagnostics for diagnosing liver fibrosis for point of care use.

PI_NAMEs: ROTELLO, VINCENT M. (contact)

PROJECT_TERMS: Acceleration;Achievement;Affinity;analytical tool;Antibodies;Area Under Curve;Automobile Driving;Binding Proteins;Biological Markers;biomarker identification;Biopsy;Cessation of life;Chemicals;chemotherapy;Cirrhosis;Clinical;clinically relevant;Complex;Complex Mixtures;Computer Models;computerized tools;Data Analyses;design;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;diagnostic value;Disease;Early Diagnosis;economic impact;Elements;Engineering;experience;fabrication;Feedback;Fibrosis;Fluorescence Resonance Energy Transfer;Foundations;Funding;Generations;Goals;Health;Immobilization;improved;insight;Investigation;Laboratories;Lateral;Life Style;Liquid substance;Liver;Liver diseases;Liver Fibrosis;liver injury;Machine Learning;Mechanics;Modeling;Monitor;Morbidity - disease rate;mortality;nanosensors;Nose;Outcome;Output;Paper;Pathologic;Patient-Focused Outcomes;Patients;point of care;point-of-care diagnostics;Point-of-Care Systems;Polymers;premature;Process;Proteins;Proteomics;prototype;rapid diagnosis;Receiver Operating Characteristics;Research;response;Sampling;sensor;Serum;specific biomarkers;Spottings;Staging;Statistical Methods;Surface;Symptoms;System;targeted treatment;Technology;Testing;Tongue;tool;Translating;Validation;Whole Blood;Wisconsin;Work

PROJECT_TITLE: Point of Care Diagnostics for Liver Disease using Fluorescent Nanosensors

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Inner ear disorders, such as hearing loss and dizziness, are often caused by degeneration of the sensory cells and neurons that relay information to the brain. We have discovered a new way to produce human inner ear cells in a culture dish. In this study, we will iteratively redesign and reformat the inner ear cells to make them more useful for testing drug or gene therapies that could regenerate a patient’s inner ear after damage.

PI_NAMEs: KOEHLER, KARL RUSSELL (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Actins;Address;Anterior;Antisense Oligonucleotides;Biological Assay;Blindness;bone;Brain;Calcium;Cell Communication;Cell Physiology;Cell Separation;Cells;Chemicals;Cochlea;Complex;Custom;Data;deafness;design;design and construction;Development;Developmental Biology;directed differentiation;Disease;disease model;Dizziness;Dorsal;drug discovery;drug testing;Ectoderm;Embryo;Engineering;Environment;Epithelial Cells;Epithelial cyst;epithelial stem cell;Epithelium;Equilibrium;experimental study;fetal;Fetal Development;Fostering;Foundations;Functional disorder;Funding;Future;gene therapy;Genetic;genetic variant;genomic data;Goals;Hair;Hair Cells;Hand;Hearing;hearing impairment;Heterogeneity;Human;Human Characteristics;human pluripotent stem cell;human tissue;Image;improved;In Vitro;induced pluripotent stem cell;inner ear development;inner ear diseases;innovation;Labyrinth;Letters;live cell imaging;Measures;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Mesoderm;Methods;Modeling;Modification;Monitor;Morphogenesis;mutant;MYO7A gene;Natural regeneration;Nature;neural;Neuroglia;Neurons;Organoids;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phase;Production;Protocols documentation;regenerative;Reproducibility;Research;Research Proposals;self assembly;Sensory;Sensory Hair;SHH gene;Signal Transduction;single cell genomics;Stains;Standardization;Study models;System;Technology;Testing;Therapeutic;therapeutic evaluation;three dimensional cell culture;Time;Tissue Microarray;Tissues;Tretinoin;Tube;Tubular formation;Usher Syndrome Type 1;vestibular system

PROJECT_TITLE: Engineering multi-lineage inner ear organoids

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project narrative Gastrointestinal nematode parasites (aka Soil-transmitted helminths, hookworms, whipworms, roundworms) are amongst the most prevalent and disease-causing parasites on earth for humans and animals, with infection leading to malnutrition, adverse pregnancy outcomes, low worker productivity, and permanent growth stunting and cognitive impairment. Very few drugs are approved to treat them, and those that are used are prone to parasite resistance and have inadequate efficacy. To meet the WHO recommended Target Product Profile for new anthelmintics, we will increase Bacillus thuringiensis (Bt) crystal (Cry) protein anthelmintic efficacy by developing effective fit for purpose formulations to improve gastric resistance and by employing two evolutionary strategies used in nature to improve Cry protein efficacy, namely (1) synergistic protein combinations and (2) synergistic swapping of domains between Cry proteins, with the eventual aim of performing safety studies of our lead Cry protein anthelmintic for clinical advancement.

PI_NAMEs: AROIAN, RAFFI V (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Accounting;Adult;adverse pregnancy outcome;Albendazole;Alleles;Amino Acids;Ancylostoma (genus);Anemia;Animals;Anthelmintics;Ascaris;Ascaris suum;Award;Bacillus subtilis;Bacillus thuringiensis;Bacteria;Canis familiaris;Caring;Child;Clinic;Clinical;Clinical Trials;Collaborations;combat;cost;Development;Digestion;disability-adjusted life years;Disease;Disease Vectors;Dose;Drug resistance;Education;efficacy testing;Engineering;Equus caballus;experimental study;Family suidae;first-in-human;Food;Formulation;Foundations;Future;gastrointestinal;Goals;Growth;Guidelines;Haemonchus;Hamsters;Hand;Helminths;Hookworms;Human;hybrid protein;Hybrids;Immune response;Impaired cognition;improved;improved outcome;In Vitro;in vitro Bioassay;in vitro testing;in vivo;in vivo evaluation;Income;Industrialization;Industry Collaboration;Infection;Insecta;Insecticides;Ivermectin;Japanese;Lead;lead candidate;Malnutrition;Measures;Medical;Milk;Modeling;Morbidity - disease rate;Multi-Drug Resistance;Mus;Nature;Necator;Nematoda;next generation;Oral Administration;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Physical Fitness;physical impairment;Planet Earth;preclinical study;Pregnant Women;Production;Productivity;productivity loss;Proteins;Recommendation;Resistance;Rodent;Rodent Model;Safety;safety study;Sheep;Sodium Bicarbonate;Soil;Stomach;synergism;System;Testing;Toxicology;Transgenic Organisms;transmission process;Trichuris;Validation;Variant;Vertebrates;Work;World Health Organization

PROJECT_TITLE: B. thuringiensis crystal proteins as powerful next-generation anthelmintics

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE About 50% of children with developmental language disorder at school entry will exhibit persistent language disorder. The early family context of children reared in poverty may influence children's risk for persistent language disorder. We test the Family Stress Model for its applicability to linking early family context to risk for persistent language disorder among children with early language difficulties.

PI_NAMEs: JUSTICE, LAURA M. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 4 year old;5 year old;9 year old;Address;Affect;Age;Attention;caregiver depression;Caregivers;Characteristics;Child;Child Language;Child Rearing;Conflict (Psychology);Data;Depressed mood;design;Development;Developmental Disabilities;Dimensions;Disparity;early childhood;Early Diagnosis;Early Intervention;Economics;Educational Status;Environment;epidemiology study;Exhibits;experience;Family;Funding;Genetic Markers;Goals;Growth;health disparity;Home;improved;Income;Individual;Interpersonal Relations;Justice;Knowledge;Language;Language Development;Language Development Disorders;Language disability;Language Disorders;language impairment;language outcome;Life;Linguistics;Link;Longitudinal Studies;Low income;low socioeconomic status;maternal depression;Measurement;Measures;Mental Health;Modeling;Parents;Pathway interactions;Phase;Poverty;Predisposition;pressure;Prognosis;prognostic indicator;psychological distress;Reading;Reading Disabilities;representation theory;Research;Research Design;Risk;Role;Sampling;Schools;Severities;skills;socioeconomic disparity;Socioeconomic Status;Specific qualifier value;Stress;Testing;theories;Work

PROJECT_TITLE: SES-Related disparities in early language development and child risk for developmental language disorder (Phase 2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because sickle cell disease (SCD) is a life-threatening blood disorder that affects millions of people worldwide, causing debilitating effects from acute painful episodes to chronic organ dysfunction, limiting quality of life and expectancy. We have identified that complement activation can drive acute chest syndrome (ACS), a major complication of SCD with high morbidity and mortality. In this proposal, we will identify mechanisms and treatment options for ACS using a multi-faceted approach of animal models, microfluidics and human samples to predict, prevent and treat ACS in SCD.

PI_NAMEs: CHONAT, SATHEESH  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Acceleration;Acute;acute chest syndrome;Address;Adhesions;Admission activity;Affect;Alternative Complement Pathway;Animal Model;Antibiotics;Attenuated;blood vessel occlusion;Cause of Death;Cell Adhesion;Cell Aggregation;Cells;Cessation of life;Chronic;Clinical;cobra venom factor;cohort;Complement;Complement Activation;complement C3 precursor;Complement Factor B;complement pathway;Complication;Correlative Study;Data;design;Development;effectiveness evaluation;efficacy testing;Endothelial Cells;Endothelium;Erythrocyte Transfusion;Erythrocytes;Exhibits;Expectancy;extracellular;Flow Cytometry;Functional disorder;Future;Genetic Models;Hematological Disease;Heme;Hemin;Hemolysis;Hemolysis Induction;Hemolytic Anemia;high dimensionality;Hospitalization;Human;human data;improved;in vitro Assay;in vivo;inhibitor;Injections;Injury;innovation;insight;Intensive Care;Intensive Care Units;Intervention;Knowledge;Life;Measures;Mediating;Microfluidics;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Nature;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel strategies;novel therapeutics;Organ;Oxygen;Oxygen Therapy Care;P-Selectin;Pain;Pathogenesis;Pathway interactions;Patient Selection;Patients;Persons;pharmacologic;Phenotype;Plasma;Play;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Process;Public Health;Publishing;Quality of life;Recurrence;Regulatory Pathway;Research;Role;Sampling;Sickle Cell;Sickle Cell Anemia;sickling;Supportive care;Testing;Therapeutic Agents;Therapeutic Intervention;therapeutic target;therapy development;TLR4 gene;Toll-like receptors;tool;translational study;Work

PROJECT_TITLE: Complement in the Pathogenesis of Acute Chest Syndrome


ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will uncover mechanisms underlying the func- tioning during acoustic communication learning of a key auditory processing stream between Core and second- ary auditory cortical fields. Elucidating the normal operation of this system for perception and learning of com- municative sounds in complex soundscapes will be important in implicating mechanisms that may fail in auditory processing disorders, social disorders with auditory dysfunctions, age-related hearing loss and temporal lobe strokes.

PI_NAMEs: LIU, ROBERT C (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Adult;Adult women;Animal Communication;Animal Model;Animals;Association Learning;Auditory;Auditory area;Auditory Perceptual Disorders;auditory processing;Auditory system;Behavior;behavior test;Behavioral;behavioral phenotyping;behavioral response;Brain;Caring;Categories;cell type;Code;Collaborations;Communication;communication behavior;Complex;Data;Detection;Discrimination;Dissection;Electrophysiology (science);Enhancers;Evolution;experience;Exposure to;Goals;Grouping;Head;Hearing;Hearing problem;Human;human old age (65+);improved;in vivo;insight;Knowledge;Language;Lateral;Learning;Link;Location;Mammals;Mediating;Mediator;Modeling;Molecular;Mus;neural;neuroethology;Neuronal Plasticity;Neurons;Noise;novel;Operant Conditioning;operation;optogenetics;Perception;Population;Presbycusis;Process;Public Health;pup;Research;response;Retrieval;Rewards;Role;Semantics;sensory neuroscience;Signal Transduction;Site;social;social communication;social deficits;Social Interaction;social learning;social neuroscience;Sorbus;sound;Speech Sound;Stimulus;Stream;Stroke;Study models;success;System;Temporal Lobe;therapeutic target;tool;Training;Ultrasonics;Viral;Vocabulary;vocalization

PROJECT_TITLE: Functional approach to communication sound processing in mouse auditory cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

PHR: Project Narrative Round 5 (R5) of the National Social Life, Health, and Aging Project (NSHAP) will continue its legacy as a nationally representative, longitudinal study of U.S. older adults focused on the links between social, cognitive, mental, and physical health trajectories. This fifth round will produce high-quality, longitudinal data that includes a fifth wave of data for Cohort 1, a third wave for Cohort 2, and a first wave for a new Cohort 3 (born 1966-80), as well as a restructured and refreshed sample which will provide better representation of Black and Hispanic older adults. R5 retains and expands measures of cognition and AD/ADRD, activity and sleep, polypharmacy, frailty, inflammation, and cardiovascular and metabolic risk, providing the scientific community, clinicians, policymakers, and the public with a valuable resource to examine the social determinants of health disparities within and between ethnoracial groups, across cohorts, and within dyads.

PI_NAMEs: WAITE, LINDA J (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Accelerometer;Adult;Affect;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Archives;Baby Booms;Biological;Biological Assay;Biological Markers;Black race;Cardiovascular system;clinical diagnosis;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Cohort Analysis;Cohort Studies;Collaborations;Communities;Complex;COVID-19;COVID-19 pandemic;Cross-Sectional Studies;Data;design;Discrimination;Disease;distributed data;end of life;ethnoracial;experience;follow-up;Follow-Up Studies;frailty;Hand Strength;Health;health disparity;Health Policy;Hearing Tests;high risk;Hispanic;Immigrant;Immigration;Individual;Inflammation;innovation;Interview;Language;Leukocytes;Life;life span;Link;longitudinal analysis;longitudinal dataset;Longitudinal Studies;Measures;media use;Medical;Mental Health;Metabolic;Michigan;mortality;mortality risk;novel;older adult;Periodicity;Persons;Pharmaceutical Preparations;Physical activity;physical conditioning;Physical Function;Physical Performance;Plasma;Policy Maker;Polypharmacy;Population;post gamma-globulins;Predictive Factor;Process;Protocols documentation;racism;rate of change;recruit;Renal function;repository;Research Personnel;Resources;Respondent;Risk;Sampling;screening;Sensory;Serum;Sleep;social;social engagement;social factors;social health determinants;social media;Social Network;social relationships;Social support;Social Well-Being;Spouses;Structural Models;Subgroup;Surveys;Time;Universities;Venous blood sampling;Walking;Whole Blood;Work;Wrist

PROJECT_TITLE: National Social Life, Health, and Aging Project: Round 5

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE: ACJ injuries are quite common among young athletes engaged in contact sports. In cases where the injury is significant and cannot heal by itself, surgical repair is necessary. The focus of this project is to evaluate the efficacy of recent surgical techniques that more completely and less invasively reconstruct the ACJ's soft tissue. The goal is to determine if these techniques can provide optimal shoulder motion, strength, and soft-tissue health over time while minimizing surgical invasiveness. The outcomes of this research will be valuable in identifying the most effective treatment for ACJ injuries, highlighting the limitations of existing techniques, and suggesting ways to improve surgical methods in the future. Ultimately, this will lead to better patient care and recovery after ACJ injury.

PI_NAMEs: ZANDIYEH, PAYAM  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acromioclavicular joint;Address;adduct;adverse outcome;Anatomy;Area;articular cartilage;Articular Range of Motion;Attention;Biomechanics;bone;Categories;clavicle;Clinical;clinically relevant;cohort;Cohort Studies;Complex;Complication;contact sports;Contralateral;Data;Development;Doctor of Medicine;effective therapy;Effectiveness;efficacy evaluation;falls;fracture risk;Future;Goals;healing;Health;Image;imaging study;improved;Inferior;injured;Injury;Joint Capsule;joint injury;Joint Instability;Joint repair;Joint structure of shoulder region;Joints;kinematics;Ligaments;Link;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Mechanics;Methods;Modernization;Motion;Musculoskeletal;Operative Surgical Procedures;Outcome;Outcomes Research;Pathology;Patient Care;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;predictive modeling;Procedures;Recommendation;reconstruction;Reconstructive Surgical Procedures;Recovery;repaired;Research;Risk;Roentgen Rays;Role;Rotator Cuff;sample fixation;Shoulder;shoulder injury;Side;Site;soft tissue;Sports Medicine;standard care;Structure;Subcategory;success;surgery outcome;Suture Techniques;Techniques;Testing;Time;time use;tissue degeneration;tool

PROJECT_TITLE: Multicenter, longitudinal study of acromioclavicular joint reconstruction techniques for restoring shoulder complex biomechanics and soft tissue health

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: MH

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Depression;Mental Health;Neurosciences;Stimulant Use and Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Communication between nerve cells in the brain is largely dependent upon neurotransmitters, including dopamine, serotonin and norepinephrine, being secreted from one nerve cell and activating receptors on adjacent nerve cells. Many important therapeutic agents, including drugs for depression, anxiety and attention deficit conditions, target membrane protein transporters that remove, or ‘uptake,’ these neurotransmitters. The research in this grant is focused on understanding how these transporters work and how important therapeutic drugs, as well as illicit agents, bind to the transporters and modify their structure and activity.

PI_NAMEs: GOUAUX, JAMES E (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Affect;Affinity;Allosteric Site;Amphetamines;anti-depressive agents;Anxiety;Applications Grants;Attention deficit hyperactivity disorder;Attentional deficit;Behavior;Binding;Binding Sites;Biochemical;Biogenic Amine Neurotransmitters;Biogenic Amines;biophysical analysis;Biophysical Process;biophysical techniques;Brain;Carrier Proteins;Cells;Chemical Synapse;Chemicals;Cocaine;Communication;computer studies;Computing Methodologies;Coupled;Coupling;Cryoelectron Microscopy;Crystallization;Desire for food;Detection;Development;Disease;Dopamine;dopamine transporter;Electron Spin Resonance Spectroscopy;Engineering;Equilibrium;Excision;Extracellular Space;Foundations;Functional disorder;Genes;Goals;Grant;Health;Human;Image;inhibitor;insight;interest;Ions;Isomerism;Ligands;Membrane Proteins;Membrane Transport Proteins;Mental Depression;Methamphetamine;Methods;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;monomer;Moods;Movement;Mutation;Names;Natural Selections;Nervous System Disorder;Nervous System Physiology;Neurologic;Neurons;neurotransmission;neurotransmitter release;neurotransmitter transport;Neurotransmitters;Norepinephrine;novel;Parkinson Disease;particle;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphorylation;Phosphorylation Site;Play;Post-Translational Protein Processing;postsynaptic;Potassium;presynaptic neurons;Process;protein expression;psychostimulant;Pump;receptor;Research;Resolution;Ritalin;Role;Selective Serotonin Reuptake Inhibitor;Serotonin;serotonin transporter;Signal Transduction;Site;small molecule;small molecule therapeutics;Sodium;Specificity;Structure;symporter;Synapses;Synaptic Cleft;targeted treatment;Therapeutic;Therapeutic Agents;Transmembrane Transport;uptake;Work;Zinc

PROJECT_TITLE: Structure and Function of Neurotransmitter Transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PUBLIC HEALTH RELEVANCE The proposed research investigates how hippocampal and frontoparietal function the human brain undergoes qualitative changes during adolescence, leading to improvements in memory and reasoning abilities during emerging adulthood. A growing body of empirical work has shown that difficulties with memory and reasoning in development are associated with poor academic outcomes, as well as with several mental health disorders with developmental onsets, including affective disorders and schizophrenia. Isolating the neural mechanisms that underlie changes in memory and reasoning ability during adolescence may thus help identify markers of atypical development and contribute to interventions that may improve both cognitive and academic outcomes.

PI_NAMEs: PRESTON, ALISON R (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;age related;age related changes;Award;Behavior;biomarker identification;Brain;Child;Childhood;Code;Cognitive;cognitive development;cohort;Complex;Computer Models;Data;Decision Making;design;Development;Dimensions;early adolescence;emerging adulthood;Event;experience;flexibility;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;high dimensionality;Hippocampus;Human;improved;Individual;Influentials;information organization;Intervention;Knowledge;Knowledge acquisition;Lateral;Learning;Life;longitudinal design;Mediating;Mediation;Memory;Mental disorders;Mood Disorders;neural;neuromechanism;novel;Outcome;Parietal Lobe;Participant;Prefrontal Cortex;preservation;Process;public health relevance;Reading;Research;Resolution;Retrieval;Sampling;Schizophrenia;Structure;System;Techniques;Testing;theories;Time;Work

PROJECT_TITLE: Hippocampal and frontoparietal mechanisms for knowledge acquisition and inference

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Rates of cannabis misuse are rising among young people, underscoring a need to identify modifiable risk factors for cannabis misuse in this age group. Sleep appears to be just such a risk factor, but cannabis-sleep relationships remain poorly understood. This project will examine sleep and circadian rhythms during cannabis use and discontinuation to better understand sleep/circadian-related mechanisms contributing to cannabis misuse.

PI_NAMEs: HASLER, BRANT P. (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;actigraphy;Acute;Adolescent and Young Adult;Affect;Age;age group;Beds;Cannabis;cannabis administration;cannabis withdrawal;Characteristics;Chronic;circadian;Circadian Rhythms;contingency management;Control Groups;Development;disorder prevention;Dose;drug testing;Electroencephalography;emerging adult;emerging adulthood;falls;Female;High Prevalence;Home;Hour;Human;Individual;innovation;Laboratories;Light;Lighting;male;marijuana use;marijuana use disorder;Measures;Melatonin;Methods;modifiable risk;Monitor;novel;Participant;Patient Self-Report;Persons;Phase;Photophobia;Photosensitivity;Physiological;Polysomnography;preference;Procedures;prospective;Protocols documentation;Public Health;Publishing;Pupil;Reporting;Research;response;Retina;Risk;Risk Factors;Rodent;Saliva;Sampling;sex;Sex Differences;Sleep;sleep onset;sleep physiology;Sleeplessness;Slow-Wave Sleep;Symptoms;Testing;Tetrahydrocannabinol;Urine;Visit;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Cannabis effects on sleep, circadian rhythms, and light sensitivity in young people

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The benefit of effective and less invasive therapies that can replace invasive surgical procedures and enhance treatment outcomes for glioblastoma multiforme (GBM) patients is significant. Biomaterial formulations providing steady and prolonged release over several months of highly effective tumor homing killer cells known as neural stem cells (NSCs), and the use of a non-invasive dosing method known as focused ultrasound (FUS) to deliver NSCs systemically and across the blood brain barrier (BBB) can potentially increase efficacy outcomes to GBM treatment regimen and transform the GBM treatment landscape. The overarching goal of this proposal is to develop and evaluate a new treatment modality that combines a biodegradable and highly tunable biomaterial scaffold and non-invasive FUS to enhance delivery of NSCs to tumor cells and to curb the treatment of GBM.

PI_NAMEs: BENHABBOUR, SOUMYA RAHIMA (contact);DAYTON, PAUL A;HINGTGEN, SHAWN

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Address;allergic response;anti-cancer;Biocompatible Materials;Biodistribution;bioscaffold;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;cancer cell;Cells;cellular engineering;Characteristics;chemoradiation;Chitosan;Clinical;clinical development;combinatorial;Combined Modality Therapy;cytotoxic;delivery vehicle;density;design;Development;Diagnosis;Dimensions;Disease;Distant;Dose;Drug Delivery Systems;efficacy evaluation;efficacy outcomes;Engineering;Enhancement Technology;Evaluation;Excision;Extravasation;Focused Ultrasound;Focused Ultrasound Therapy;Formulation;Fostering;Glioblastoma;Goals;Health Benefit;Home;Homing;hydrogel scaffold;Hydrogels;Improve Access;improved;In Situ;in vivo;Injectable;Injections;innovation;Killer Cells;Malignant neoplasm of brain;manufacturing process;Marketing;Mediating;Methods;Microbubbles;migration;minimally invasive;Modality;mouse model;Nature;neoplastic cell;nerve stem cell;neuro-oncology;novel;novel therapeutic intervention;Operative Surgical Procedures;Patients;pre-clinical;Pre-Clinical Model;Process;Property;Proteins;Public Health;rational design;Recurrence;Recurrent tumor;Regimen;Research Personnel;Residual Neoplasm;Residual state;Resolution;response;Route;Safety;scaffold;self-renewal;spatiotemporal;stem cell therapy;Surgical incisions;Surgically-Created Resection Cavity;survival outcome;Technology;Testing;Therapeutic;Time;TNFSF10 gene;Toxic effect;treatment optimization;Treatment outcome;Treatment Protocols;tumor;Variant

PROJECT_TITLE: Enhanced Delivery of Cytotoxic Neural Stem Cells for Treatment of Glioblastoma Multiforme Using an Innovative In-situ Thermogelling Hydrogel and Focused Ultrasound

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]