NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Multiple myeloma (MM) is a life-threatening plasma cell malignancy that is 2-3 times more common in African Americans, and is preceded by an asymptomatic stage called smoldering multiple myeloma (SMM) amenable to early therapy. We need to determine why MM occurs more frequently in blacks, identify new biomarkers that predict patients with SMM at high risk of progression, and develop a screening strategy to identify SMM in high risk populations.

PI_NAMEs: KUMAR, SHAJI KUNNATHU;RAJKUMAR, S VINCENT (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Affect;African American;African American population;Age;ancestry analysis;Biological Assay;biomarker identification;Black Populations;Cells;Cessation of life;Chromosome abnormality;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Cytogenetics;Detection;Diagnosis;Disease;DNA;DNA Sequence Alteration;DNA sequencing;Early Intervention;Early treatment;Eligibility Determination;Etiology;Family;First Degree Relative;Flow Cytometry;Genetic Determinism;Genomics;Genotype;Goals;Grant;high risk;high risk population;Immune;Immunoglobulins;improved;Incidence;insight;Institution;Laboratories;Lesion;Life;Malignant Neoplasms;Marrow;Mass Spectrum Analysis;Measurement;Measures;Molecular Abnormality;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;mortality;Multiple Myeloma;National Health and Nutrition Examination Survey;neoplastic cell;Newly Diagnosed;Organ;Patient Selection;Patients;Persons;Phase;Plasma Cells;population based;Predictive Factor;predictive marker;Predisposition;premalignant;Prevalence;Prevalence Study;prevent;Preventive treatment;progression marker;progression risk;Proteins;Race;racial difference;racial disparity;Research;Risk;Risk Estimate;Risk Factors;risk prediction;Sampling;screening;specific biomarkers;Symptoms;Therapeutic Intervention;Time;treatment strategy;Tumor Burden;tv watching

PROJECT_TITLE: Onset and biomarkers for progression of monoclonal gammopathies

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: KO, LINDA K. (contact)

PROJECT_TERMS: Address;Advocate;Age;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American;American Indians;Area;Articulation;Awareness;biological heterogeneity;Brain;care seeking;Caregivers;Caring;Characteristics;Clinic;Clinical;clinical heterogeneity;Clinical Trials;Cognitive;cognitive function;cohort;Collaborations;Color;Communities;community organizations;community partners;County;Dementia;dementia risk;Diagnosis;Dimensions;Disease;Disparity;Education;Education and Outreach;eligible participant;Ensure;Equitable healthcare;Ethnic Origin;Ethnic Population;Event;experience;Friends;General Population;Geography;Goals;Health;Health Promotion;HIV;human old age (65+);Impaired cognition;improved;Incidence;Individual;innovation;Journals;Knowledge;Latinx;Learning;low socioeconomic status;Malignant Neoplasms;Medical center;Memory;Mental Health;metropolitan;Minority;Mission;Modeling;native elder;Native-Born;Neighborhoods;Newsletter;Nonprofit Organizations;Not Hispanic or Latino;novel strategies;outreach;Participant;Patients;Persons;Population;Prevalence;prevent;Process;programs;Provider;Publications;Race;racial population;Readiness;Recommendation;recruit;Research;Research Personnel;Resources;Risk Factors;Science;sex;social;Social Functioning;social stigma;Stigmatization;Subgroup;Surveys;Target Populations;Tribes;Underrepresented Populations;Universities;urban Native American;Vietnamese;volunteer;Washington;web site;Wellness Center;Work

PROJECT_TITLE: Outreach, Recruitment, and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: GRABOWSKI, THOMAS J. (contact)

PROJECT_TERMS: Abbreviations;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Anatomy;Architecture;Archives;Automobile Driving;Autopsy;biological heterogeneity;Biological Markers;Blood;Brain;Brain region;cell repository;central database;Cerebral cortex;Characteristics;Classification;Clinic;Clinical;Cognition;Cognitive;cohort;Data;Data Analyses;data management;Data Science;Data Set;Dementia;Dimensions;education research;Enrollment;Ensure;Foundations;Funding;Genetic;Goals;Heterogeneity;human subject;Image;Image Analysis;imaging study;Impaired cognition;in vivo;Informatics;Letters;Link;Liquid substance;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;medical schools;Memory;molecular imaging;MRI Scans;multidisciplinary;National Institute on Aging;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neuroimaging;neuropathology;novel;outreach;Participant;Pathologic;Pattern;Phenotype;phenotypic data;Positron-Emission Tomography;Process;Quality Control;recruit;repository;Research;Research Personnel;resilience;Resources;Sampling;Source;Specificity;statistics;Structure;Tissue Sample;Universities;Washington;Wellness Center

PROJECT_TITLE: Imaging and Biomarker Core


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: RENO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Program Director/Principal Investigator (Last, First, Middle): Cobine, Caroline, A Project Narrative The lower esophageal sphincter (LES) provides an important barrier between the stomach and esophagus. Dysfunction of the LES produces either reflux of gastric contents and damage to the LES, or achalasia, the inability to relax the LES after swallowing, thus preventing food from entering the stomach. This project will investigate the cellular and molecular mechanisms of contractile tone in the LES with the hope that the new pathways investigated may help suggest novel therapies for medical treatment of gastric reflux or achalasia. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: COBINE, CAROLINE ANN (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Achalasia;Address;Animals;Antibodies;aspirate;Barrett Esophagus;Biochemical;Calcium;carcinogenesis;Cells;Chest;Chronic;CLCA2 gene;Complex;Coupled;Data;Defect;Deglutition;Development;Digestion;Distal;Drug usage;Equilibrium;Esophagus;experience;experimental study;Food;Foundations;Functional disorder;Future;Gene Expression;Generations;Genetic;Giant Cells;Human;Hypotensives;Image;Immunohistochemistry;Inferior esophageal sphincter structure;Inflammatory;Ingestion;interstitial cell;Interstitial Cell of Cajal;Investigation;Label;Macaca;Macaca fascicularis;Maintenance;Measurement;Mediating;Medical;Metabolic;Molecular;Monitor;Motility;motility disorder;mouse model;Mucous Membrane;Mus;Muscle;neural;Neurons;neuroregulation;neurotransmission;new therapeutic target;Nitric Oxide;Nitroxidergic Nerves;novel;novel therapeutics;Nutrient;optogenetics;Outcome;oxidative DNA damage;Pain;Paper;Pathway interactions;Patients;Phosphorylation;Physiological;preclinical study;prevent;Primates;Principal Investigator;Probability;Process;programs;protein expression;Reflex action;Reflux;Regulation;Relaxation;Resolution;Respiratory Diaphragm;Respiratory System;response;Role;Smooth Muscle Myocytes;Stomach;Stomach Content;Structure;Techniques;Transgenic Mice;voltage;ward

PROJECT_TITLE: Control of motility in the lower esophageal sphincter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Functional connectivity brain networks are a promising tool for the identification of biomarkers of adolescent psychopathology, yet heterogeneity between and within individuals limits the validity of inferences made from group-averaged, time-invariant networks. This project will examine the level of data aggregation (group, subgroup, or individual) and time scale (static or dynamic) of resting state connectivity networks necessary for valid individual-level inferences and use these findings to predict adolescent anxiety and depression. Findings will be critical to determining methods of estimating functional connectivity networks that are representative of individuals such that inferences made using them have improved potential for clinical translation.

PI_NAMEs: MATTONI, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 12 year old;Address;Adolescence;Adolescent;Anxiety;Applied Research;Behavioral;Biological Markers;biomarker identification;Brain;career;child depression;Clinical;clinical diagnosis;clinical translation;cognitive development;Collaborations;Control Groups;Data;Data Aggregation;Dependence;Depressed mood;Development;Diagnosis;Diffuse;Disease;Educational workshop;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;Goals;Health;Heterogeneity;imaging study;improved;Individual;Individual Differences;interest;Intervention;Life;Machine Learning;machine learning method;Mental Depression;Methods;Modeling;network models;neural;Neurobiology;Neurophysiology - biologic function;Neurosciences;Outcome;outcome prediction;Pattern;person centered;Persons;Process;Prognosis;Property;Psychopathology;Research;Research Activity;Research Personnel;Research Proposals;Resources;Rest;Rewards;Risk;Sample Size;Sampling;Scanning;societal costs;Subgroup;Testing;Time;tool;Training;trait;translational barrier;Work

PROJECT_TITLE: Between- and Within-Person Heterogeneity in Adolescent Resting State Networks: Associations with Internalizing Psychopathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: JOHANSSON, PATRIK LENNART (contact)

PROJECT_TERMS: Address;Alaska Native;Alaska Native population;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian Population;American Indians;Articulation;biological heterogeneity;Caregivers;Clinical;Code;Collaborations;Communities;community based participatory research;community involvement;Compensation;Congresses;Data;data sharing;design;Disparity;Disparity population;distrust;Educational workshop;effectiveness evaluation;Enrollment;Equity;expectation;experience;fly;Focus Groups;Funding;Goals;Government;Health;health disparity;Helicopter;Individual;informant;innovation;interest;Interview;Knowledge;Lead;Learning;Life Expectancy;Magnetic Resonance Imaging;Mass Media;member;Modeling;National Institute on Aging;native elder;Native-Born;neglect;neuroimaging;Participant;participant enrollment;Perception;Phase;Population;Poverty;programs;promoter;Protocols documentation;Publications;Qualitative Research;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resources;Rewards;Rural;rural Americans;Services;Time;Translating;tribal Nation;tribal organization;Tribal-academic partnership;Tribes;Universities;Washington;Work

PROJECT_TITLE: Native Research and Resource Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Injury to the spinal cord results in paralysis below the level of the injury, and current therapeutic strategies are ineffective at restoring function. In this proposal, we focus on strategies to attenuate the acute inflammatory response, and then to alter the environment in the chronic spinal cord injury in order to promote regeneration and restoration of function. At the chronic time point, we combine biomaterial bridges with microtubule stabilization to support the regeneration of motor tract through the injury with re-entry to the host tissue.

PI_NAMEs: ANDERSON, AILEEN J;CUMMINGS, BRIAN JOHN;SHEA, LONNIE D (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Anti-Inflammatory Agents;Architecture;Attenuated;Axon;axon growth;axon regeneration;behavior test;Behavioral Assay;Biocompatible Materials;Cell Death;Cervical spinal cord injury;Chronic;Clinic;combinatorial;Combined Modality Therapy;Complex;Contusions;Corticospinal Tracts;Cyst;Defect;Demyelinations;Environment;Epothilone B;functional restoration;Gene Delivery;gene therapy;Genes;Geometry;Goals;Growth;immunoregulation;Implant;implantation;In Situ;Individual;Inflammation;Inflammatory Response;Injury;innovation;Interleukin-10;Interleukin-10 Overexpression;Interleukin-4;Intervention;Lentivirus;Lesion;Leukocytes;Locomotor Recovery;Measures;Mediating;Microtubule Stabilization;Microtubules;Modeling;Modification;Motor;myelination;Natural regeneration;neural repair;neurodevelopment;Neurons;novel;Oligodendroglia;Paralysed;Patients;Penetration;pharmacologic;Pharmacologic Substance;prevent;Process;programs;Recovery;Recovery of Function;recruit;regenerative;Research;restoration;safe patient;Site;Spinal Cord;Spinal cord injury;spinal cord repair;spinal pathway;Structure;Synapses;synaptogenesis;Testing;Therapeutic;Therapeutic Intervention;Thoracic Injuries;Time;Tissues;Translations;Tube

PROJECT_TITLE: Multi-channeled Bridges for Promoting Chronic Spinal Cord Repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE Afro-Latinas may be disadvantaged in health outcomes due to the intersectionality of multiple minority identities and distinctive stressors of societal disadvantages, such as residential racial segregation, neighborhood deprivation, and prenatal care utilization. This study aims to use Florida Vital Statistics data to determine differences in pregnancy-related hypertension, pregnancy-related diabetes, preterm birth, and low birth weight among Afro-Latinas compared to mothers of other racial/ethnic identities. The findings from this study will provide important data on Afro-Latina-specific perinatal disparities.

PI_NAMEs: PARRA, ALEXA MERCEDES (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Adult;adverse birth outcomes;Age;Award;Birth;Birth Weight;Black Populations;Black race;black women;Body mass index;career;career development;Categories;Characteristics;Child;child bearing;Data;data management;delivery complications;deprivation;Development;Diabetes Mellitus;Disadvantaged;Discrimination;Disparity;ethnic identity;Ethnic Origin;Ethnic Population;experience;Fellowship;fighting;Florida;Foundations;Gestational Diabetes;Goals;Growth;Health;health disparity;health equity;health inequalities;Heterogeneity;Hispanic;Hispanic Populations;Hispanic Women;Hypertension;improved;Individual;Inequity;Infant;Infant Health;innovation;intersectionality;Intervention;Latina;Latina Population;Latino;Latino Population;Learning;Literature;Low Birth Weight Infant;low socioeconomic status;Maternal and Child Health;Maternal Health;maternal morbidity;maternal risk;Measures;Mentorship;Methodology;Minority;Mothers;neighborhood disadvantage;Neighborhoods;Nurses;Outcome;Perinatal;perinatal outcomes;Persons;Pre-Eclampsia;Pregnancy;Premature Birth;Prenatal care;prepregnancy;Race;racial disparity;racial population;Racial Segregation;racism;Registered nurse;reproductive;Research;research and development;Research Methodology;Research Personnel;residential segregation;Scientist;skills;skills training;skin color;Small for Gestational Age Infant;social health determinants;stressor;Subgroup;theories;Training;Translating;United States;Vital Statistics;Vulnerable Populations;White Women;Woman;women of color;women's outcomes;Work

PROJECT_TITLE: The Effects of Intersecting Identity and Social Determinants of Health on Afro-Latina Maternal Morbidity and Infant Birth Outcomes in Florida

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: ILIFF, JEFFREY J (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Animal Model;Award;Basic Science;Big Data;Bioinformatics;Biological;biological heterogeneity;Biological Markers;Brain;career;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;Competence;Correlation Studies;Data;Data Set;data sharing;Dementia;Development;Disease;Ecosystem;education research;Educational Curriculum;Educational workshop;Environment;Etiology;Faculty;Focus Groups;Fostering;Funding;Future;Genetic;Goals;Grant;Home;Human;Image;improved;Individual;innovation;Institution;interdisciplinary approach;Interest Group;Knowledge;Knowledge Portal;literacy;Medicine;meetings;Memory Loss;Mentors;Mentorship;Minority;multidisciplinary;Native American community;Native Hawaiian or Other Pacific Islander;Nerve Degeneration;neurobehavior;neuropathology;Neurosciences;outreach;Participant;Pathologic;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevention;programs;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Series;Structure;Technical Expertise;Teleconferences;Time;tool;Training;transcriptomics;Translating;Translational Research;Travel;Universities;Washington;working group

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The Populations Underrepresented in Mental illness Association Studies (PUMAS) Project will collect samples from 17,000 individuals with severe mental illness from across African and the Americas to create a total sample dataset of 183,000 from across Africa and the Americas. We will generate and analyze whole genome sequencing data on 40,000 schizophrenia patients, 40,000 bipolar patients and 40,000 controls to learn the similarities and differences of the genetic architecture of severe mental illness across diverse ancestries and environments.

PI_NAMEs: MULLE, JENNIFER GLADYS;PATO, CARLOS N (contact);PATO, MICHELE T

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;African;African ancestry;Americas;Area;Biological;Bipolar Disorder;bipolar patients;Code;Collaborations;Collection;Data;Data Set;data sharing;Disease;Environment;Ethnic Origin;European ancestry;exome;exome sequencing;Gene Frequency;Generations;Genes;Genetic;genetic architecture;Genetic Research;Genetic study;Genetic Variation;genome sequencing;Genotype;health care disparity;Individual;insight;International;knowledge base;Latin American;Latino;Latino Population;Learning;Maps;Medicine;Mental disorders;Meta-Analysis;Mutation;National Institute of Mental Health;Native American Ancestry;Native Americans;Outcome;Patients;Phenotype;polygenic risk score;Population;Population Control;Population Heterogeneity;psychiatric genomics;psychogenetics;Quality Control;rare variant;recruit;Reduce health disparities;Research Personnel;response;risk variant;Sample Size;Sampling;Sampling Studies;Schizophrenia;severe mental illness;Severities;Single Nucleotide Polymorphism;South Africa;South America;success;Underrepresented Populations;Variant;variant detection;whole genome

PROJECT_TITLE: 3/4 Powering Genetic Discovery for Severe Mental Illness in Latin American andAfrican Ancestries


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative The World Health Organization (WHO) recommends screening and prophylaxis for opportunistic infections (OIs) for people with advanced HIV disease (CD4<200 cells/µL) who are at high risk for OIs and death. The objective of this study is to evaluate point-of-care CD4 testing to improve survival in people with advanced HIV disease and evaluate an enhanced package of OI screening and prophylaxis to build on current WHO recommendations. The findings from this study will impact international HIV treatment guidelines on optimal management of persons with advanced HIV disease in order to decrease HIV-related mortality globally.

PI_NAMEs: RAJASINGHAM, RADHA  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Africa South of the Sahara;Antifungal Therapy;Antigens;antiretroviral therapy;Biological Assay;Blood;care seeking;Caring;CD4 Lymphocyte Count;Cells;Cessation of life;Clinic;Clinical;Clinical Trials;Cluster randomized trial;cost;Cost Analysis;cost effectiveness;cost-effectiveness evaluation;Coupled;Cryptococcal Meningitis;Cryptococcus;Data;Diagnostic;diagnostic screening;Disease;Flow Cytometry;Fluconazole;Funding;Guidelines;Health;Health Personnel;high risk;high risk population;HIV;Hospital Costs;Hospitals;immune reconstitution;improved;Infection;Inflammatory;International;isoniazid;lateral flow assay;Meningitis;mortality;novel;Opportunistic Infections;Performance;Persons;Plasma;point of care;point-of-care diagnostics;Prophylactic treatment;Randomized;randomized trial;Recommendation;Retrospective cohort;rifapentine;Risk;Scotland;screening;screening guidelines;Serum;Specificity;standard of care;Syndrome;Testing;Time;transmission process;treatment guidelines;Tuberculosis;tuberculosis treatment;Uganda;urinary;Venous;Visual;World Health Organization

PROJECT_TITLE: An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Genetics;Heart Disease;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Chronic heart failure is a leading cause of morbidity and mortality in the USA, and patients suffering from this disease have limited therapeutic options that include the surgical implantation of ventricular assist devices and heart transplants. Based on preliminary data I collected, I hypothesize that myocardial lactate production and consumption is integral to cardiac health, and quantifying and understanding this metabolism will uncover novel therapeutic targets to treat cardiac hypertrophy and heart failure.

PI_NAMEs: CLUNTUN, AHMAD A (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Adult;Affect;aorta constriction;Biochemistry;Bioenergetics;Biology;blood pump;Carbon;Cardiac;Cardiac health;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cells;Cellular Metabolic Process;Chemicals;Citric Acid Cycle;Clinical Research;Coenzyme A;Complex;Congestive Heart Failure;Consumption;Coupled;Cultured Cells;Cytoplasm;Data;defined contribution;Development;Disease;DNA Sequence Alteration;Environment;Environmental Risk Factor;Enzymes;Equilibrium;experimental study;extracellular;Generations;Genes;Genetic Models;Glucose;Glycolysis;Health;Heart;heart dimension/size;Heart failure;heart function;Heart Hypertrophy;Heart Transplantation;Heart-Assist Devices;histone modification;Histones;Homeostasis;Human;Hypertrophic Cardiomyopathy;Hypertrophy;implantation;Inherited;inhibitor;Intervention;Isotopes;left ventricular assist device;Left ventricular structure;Mentors;Metabolic;Metabolic Pathway;Metabolism;Methods;Mitochondria;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myocardial;Myocardium;new therapeutic target;non-histone protein;novel;novel therapeutic intervention;Operative Surgical Procedures;oxidation;Oxidative Phosphorylation;Pathogenicity;Pathologic;Patients;Pattern;Penetrance;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Positioning Attribute;Post-Translational Protein Processing;pressure;Process;Production;programs;Publishing;Pyruvate;Recovery;Regulation;Reporting;Research;response;Role;Signal Transduction;stable isotope;System;Systolic heart failure;Testing;Therapeutic;Tissue Sample;Tracer;transcriptomics;ventricular assist device;Waste Products;Work

PROJECT_TITLE: Impact and regulation of lactate metabolism in the heart

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The proposed research seeks to determine how diffusion of cardiac technology, specifically percutaneous coronary intervention (PCI), may differentially affect disadvantaged versus non-disadvantaged communities, through changing the types of patients that receive PCI and also the quality of care. This study is relevant to public health because it will provide local, state, and federal bodies with the empirical findings they need to better understand how to balance the benefits and costs of PCI across varying communities, ultimately to create data-driven solutions to the provision of cardiac technology that can both improve overall population health and narrow disparities among disadvantaged communities and individuals. This project is directly aligned with one of NHLBI's Enduring Principles to “innovate an evidence-based elimination of health inequities in the United States.”

PI_NAMEs: HSIA, RENEE YUEN-JAN (contact);SHEN, YU-CHU

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: access disparities;Acute myocardial infarction;Address;Admission activity;Adopted;Adverse event;adverse outcome;Affect;Area;Attention;Automobile Driving;Black race;built environment;California;Cardiac;Cardiology;Caring;Censuses;Certificate of Need;Clinical;Communities;Costs and Benefits;Credentialing;Data;Databases;design;Diffusion;Disadvantaged;Discrimination;Disparity;disparity gap;Disparity population;Environment;Equilibrium;Equity;ethnic minority;Ethnic Origin;evidence base;experience;federal policy;Goals;Growth;Health;health disparity;health disparity populations;health equity;health inequalities;Health Service Area;high risk;Hispanic;Hospitals;improved;Income;Individual;Infrastructure;innovation;Inpatients;Institution;Intervention;Legal;lens;Licensing;Lifting;Link;Literature;Low income;Low Income Population;Measures;Medical;Medicine;Modeling;mortality;National Heart, Lung, and Blood Institute;neighborhood disadvantage;New Jersey;Not Hispanic or Latino;Outcome;Outpatients;Pathway interactions;Patient Discharge;Patient risk;Patients;Pattern;percutaneous coronary intervention;Physicians;Policies;Policy Maker;population based;population health;Probability;profiles in patients;Public Health;Quality of Care;Race;racial minority;Registries;Regulation;Research;Resources;revascularization;Risk;Risk Adjustment;segregation;service intervention;Signal Transduction;social health determinants;Statutes and Laws;Structural Racism;System;Technology;technology intervention;Testing;trend;Uninsured;United States;United States National Institutes of Health;Unstable angina;Variant;willingness

PROJECT_TITLE: Expansion of Percutaneous Coronary Intervention in Outpatient and Inpatient Settings: Quantifying the Differential Impact Between Disadvantaged and Non-Disadvantaged Communities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Physical Injury - Accidents and Adverse Effects;Radiation Oncology;Rare Diseases;Regenerative Medicine

ORG_CITY: PASADENA

ORG_NAME: BCN BIOSCIENCES, LLC

PHR: PUBLIC HEALTH RELEVANCE: Excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in the United States. The American Cancer Society's estimates for the number of colorectal cancer cases in the United States for 2022 are: 106,180 new cases of colon cancer. 44,850 new cases of rectal cancer. According to Foundation Medicine (FM) it is estimate that KRAS mutation frequencies of approximately 50% exist in colorectal cancers. KRAS mutations are present in approximately 25% of all tumors, making them one of the most common gene mutations linked to cancer. They are frequent drivers in lung, colorectal and pancreatic cancers. KRAS drives 32% of lung cancers, 40% of colorectal cancers, and 85% to 90% of pancreatic cancer cases. Mutations G12C, G12D/V and G12/13R are some of the most common KRAS mutations but G12D and V dominate colorectal and pancreatic cancers which is the largest and what we are targeting in this proposal. This work involves breakthrough technology which can target hard to treat KRAS mutations such as G12D and G12V where there are no currently approved drugs to treat this deadly disease. It is estimated that for colorectal cancers alone, this research and finding may impact 30-40% of the colorectal cancer population equating up to ~ 60,000 people annually in the USA alone.

PI_NAMEs: NORRIS, ANDREW JOHN (contact);SAHA, SUBHRAJIT

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Acute;Affect;American Cancer Society;Ames Assay;animal rule;Animals;Anti-Inflammatory Agents;Antineoplastic Agents;Applications Grants;Biological Models;Biological Sciences;Body mass index;Bone Marrow;Bone Marrow Cells;Bone Marrow Involvement;cancer diagnosis;Cancerous;Carcinoma;CCL2 gene;Cell Death Induction;Cells;chemokine;Chemotherapy and/or radiation;Chromosome abnormality;Clinical;Colon Carcinoma;Colorectal Cancer;colorectal cancer treatment;Complex;Data;Data Reporting;design;Development;Disease;Dose;driver mutation;drug development;Epithelium;Equation;Exclusion;Exposure to;Foundations;Frequencies;gastrointestinal;gastrointestinal epithelium;Gene Mutation;Grant;Hematopoietic;Hematopoietic System;Human;immunoregulation;Inflammation;Inflammatory;inhibitor;Injury;intestinal epithelium;Intestines;Investigation;Ionizing radiation;irradiation;Knowledge;KRAS oncogenesis;KRAS2 gene;lead candidate;LGR5 gene;Ligands;Link;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;Modeling;mouse model;Mucous Membrane;mutant;Mutation;Myeloid Cells;Natural regeneration;neoplastic cell;Non-Small-Cell Lung Carcinoma;nonhuman primate;Normal tissue morphology;Nuclear Accidents;Oncogenic;Organoids;Oryctolagus cuniculus;overexpression;Paper;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phenotype;Phosphoric Monoester Hydrolases;Plasma;Play;Population;pre-clinical;pre-Investigational New Drug meeting;prevent;product development;Proteins;PTEN gene;public health relevance;Publishing;Radiation;Radiation Dose Unit;Radiation exposure;Radiation Injuries;radiation mitigation;Radiation Toxicity;radiation-induced injury;RAS Family Gene;recruit;Rectal Cancer;regeneration following injury;regenerative;regenerative therapy;repaired;Reporting;Research;Research Personnel;Resistance;resistance mechanism;Rodent;Role;Route;Safety;safety study;Schedule;Sepsis;Signal Transduction;Skin Cancer;Small Business Innovation Research Grant;stem cells;STEM field;subcutaneous;success;Syndrome;System;systemic inflammatory response;Technology;Testing;Therapeutic Index;timeline;Tissues;Toxic effect;Toxicology;tumor;Tumor Suppressor Proteins;United States;Up-Regulation;Validation;Whole-Body Irradiation;Work

PROJECT_TITLE: Mitigation of Radiation Induced Gastrointestinal Syndrome.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(11)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Patients with Hypersensitivity Pneumonitis experience poor health-related quality of life without access to interventions that target improvement in this outcome. The goal of this proposal is to develop and determine the feasibility and acceptability of a stakeholder-engaged behavioral and educational intervention to improve the health-related quality of life of patients with hypersensitivity pneumonitis. Findings from this innovative pilot randomized trial will lay the groundwork for a future, multi-site, randomized trial testing the effectiveness of the intervention developed here.

PI_NAMEs: ARONSON, KERRI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;American;Antigens;Anxiety;attentional control;Attitude;Behavior Therapy;Behavioral;Benchmarking;career;career development;Chest;Chronic Disease;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive Therapy;Collaborations;coping;design;Development;Development Plans;Disease;Education;Educational Intervention;Educational Materials;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;eHealth;evidence base;experience;Exposure to;Extrinsic allergic alveolitis;Feeling;fibrotic interstitial lung disease;Focus Groups;Foundational Skills;Foundations;Fright;Frustration;Future;Goals;Health;health administration;health related quality of life;Home environment;Hybrids;implementation evaluation;implementation outcomes;implementation science;improved;Infrastructure;innovation;instrument;International;Interstitial Lung Diseases;Intervention;Investigation;Knowledge;Knowledge acquisition;Learning;Life Style;Measures;Medicine;Mental Depression;Mentors;novel;Observational Study;Outcome;Outcomes Research;Participant;Patient Education;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patient-Focused Outcomes;Patients;peer;peer coaching;Peer Group;Persons;pilot test;preference;Protocols documentation;Psychometrics;Qualitative Research;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Design;Research Methodology;Research Personnel;retention rate;Review Literature;Sampling;Scientist;Self Efficacy;Site;skills;Social isolation;Societies;Source;Statistical Data Interpretation;Surveys;System;Testing;theories;therapy development;Thinness;Training;Uncertainty;Universities;Virginia;virtual;Visit;web site;Work

PROJECT_TITLE: Rise-HP: Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis; A Stakeholder Engaged Intervention to Improve Health-Related Quality of Life

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Genetics;Immunotherapy

PHR: Project Narrative Harnessing immune pathways to attack a diseased state, or immunotherapy, is a proven and powerful way to treat disease such as cancer. Yet, there are many natural checkpoints in place to prevent an aberrant immune response. Proposed studies are designed to identify and modulate innate immune checkpoints to reveal previously unsuspected ways to exploit innate immune pathways to treat disease.

PI_NAMEs: BASS, BRENDA L. (contact);ELDE, NELS C.;JACKMAN, JANE ELIZABETH;STETSON, DANIEL B

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: ADAR1;Affect;Animals;Anti-viral Response;arm;Autoimmune Diseases;Autoimmunity;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biological Process;Caenorhabditis elegans;Candidate Disease Gene;Cell Death;Cell Line;Cells;checkpoint modulation;Chemicals;Communicable Diseases;comparative;Conflict (Psychology);Deamination;design;Detection;Disease;Double-Stranded RNA;ds RNA-Binding Proteins;dsRNA adenosine deaminase;Engineering;Enzymes;Epitopes;Evaluation;Evolution;Experimental Models;experimental study;Family;Future;Genes;Genetic;Genome;Goals;Hand;Homologous Gene;Immune;immune function;Immune response;Immunity;Immunoprecipitation;Immunotherapy;In Vitro;innate immune checkpoint;innate immune pathways;Innate Immune Response;innovation;insight;Interferons;Intervention;Invaded;Invertebrates;Knowledge;Logic;Malignant Neoplasms;Mammalian Cell;Mammals;Masks;Mediating;Medical;member;model organism;Molecular;Molecular Biology;Monitor;Mus;Orthologous Gene;Outcome;Pathway interactions;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phylogenetic Analysis;Population;prevent;programs;Proteins;Recording of previous events;Reporting;response;RNA;RNA Interference;RNA-Directed RNA Polymerase;Role;Sampling;Scientist;sensor;Signal Transduction;Source;Specificity;Substrate Specificity;Testing;theories;therapy outcome;tripolyphosphate;tumor;tumorigenesis;Vertebrates;Viral;viral RNA;Virus;Work

PROJECT_TITLE: Unlocking evolutionarily latent immune functions for treating disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Lipids are molecular components of biological organisms and play a vital role in maintaining cellular functions. Dysregulated lipid metabolism has been recognized in the pathogenesis of a variety of diseases including many cancers, neurodegenerative disorders, cardiovascular disease, and diabetes. Thus, lipid analysis technology aimed at elucidation of full lipid composition and complete structures hold great promise for revealing disease mechanisms and providing new opportunities for disease diagnosis and treatments. The proposed research addresses the current deficit of such technologies through the development of a mass spectrometric probe equipped with novel microdroplet electrochemical methods for complete lipid structural analysis in complex biological samples.

PI_NAMEs: YAN, XIN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Address;Biological;Cardiac;Cardiovascular Diseases;Cell Physiology;Characteristics;Chemicals;Complex;Derivation procedure;Development;Diabetes Mellitus;Diabetic mouse;Diagnosis;Diagnostic;Disease;disease diagnosis;Geometry;Heart;Homeostasis;instrumentation;Ions;Isomerism;Length;lipid metabolism;lipid structure;lipidome;lipidomics;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;method development;Methods;Molecular;Neurodegenerative Disorders;new technology;next generation;novel;Organism;Outcome;Pathogenesis;Pathology;Physiological;pi bond;Play;Positioning Attribute;Prediabetes syndrome;programs;Reaction;Research;response;Role;Running;Sampling;Specificity;Structure;Structure-Activity Relationship;System;Technology;tool;Vision;voltage;western diet

PROJECT_TITLE: Panoptic electrochemical probe for next-generation mass spectrometry based-lipidomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Aging;Social Determinants of Health

ORG_CITY: MONTGOMERY

ORG_DEPT: BIOLOGY

ORG_NAME: ALABAMA STATE UNIVERSITY

ORG_STATE: AL

PHR: Project narrative: Prior reports have demonstrated that the engagement, capacity, and continuity approach has been effective in retaining and motivating students from underserved backgrounds in Medicine, Science, Technology, Engineering, and Math (MSTEM). The primary purpose of the proposed undergraduate research experience proposal is to encourage development of scientific research skills, students will be exposed to aging related educational and research preparation at Alabama State University (ASU), a Historically Black College and University, and research experience at the Auburn University, a major research University. This opportunity will enable students to interact with faculty, staff, graduate students, and postdoctoral fellows and enrich their education in aging related disciplines, and preparing them for graduate school.

PI_NAMEs: MISHRA, MANOJ K. (contact);SUPPIRAMANIAM, VISHNU D

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;African American student;Aging;aging related;aging related disease;Alabama;Ally;Basic Science;Bioethics;Biology;career;career development;Communities;design;Development;Development Plans;Diet;Discipline;Disease;disease disparity;Doctor of Philosophy;Education;Education Projects;Educational workshop;Ensure;Environment;experience;Exposure to;Faculty;Foundations;Funding Agency;Genetic;Goals;graduate school;graduate student;Health;health care availability;health disparity;Health Personnel;Historically Black Colleges and Universities;improved;Incidence;Institution;inter-institutional;Interdisciplinary Study;Knowledge;Leadership;Learning Module;Medical;Medicine;Mentors;Minority;multidisciplinary;organizational structure;Outcome;peer coaching;Population;Postbaccalaureate;Postdoctoral Fellow;Preparation;programs;Public Speaking;rapid growth;Readiness;recruit;Reporting;Research;Research Infrastructure;Research Project Grants;Research Training;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;skills;Social Behavior;Socioeconomic Factors;statistics;Student Selections;student training;Students;success;summer research;symposium;Training;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;underserved students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Alabama State University-Auburn University Partnership to Promote Diversity in Aging Research


NIH_SPENDING_CATS: Complementary and Integrative Health;Microbiome

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The human gut microbiome is intimately connected with health, with disruptions of its ecological composition associated with numerous diseases. Manipulations of the microbiome via fecal microbiome transplants, in which microbial strains derived from healthy donor stool are introduced to a patient's gut community, have been found to be effective treatments for some diseases but not all. This project will determine the evolutionary processes relevant for colonization and persistence of invading strains to a microbiome community, and in doing so will make contributions relevant both to the basic science of microbiome evolutionary dynamics as well as clinical treatment of microbiome–associated diseases

PI_NAMEs: GARUD, NANDITA  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Evolutionary Dynamics of the Human Gut Microbiome During Colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Hybrid dysfunction presents an unparalleled opportunity to understand how species diverge in key developmental processes, but despite the commonality and importance of hybrid dysfunction as a foundational process in diversification, we lack an understanding of the evolutionary drivers and genetic basis of most hybrid incompatibilities. I aim to dissect the evolutionary drivers and genetic basis of one of the most important, but understudied incidences of hybrid dysfunction in viviparous organisms- embryo inviability caused by inappropriate development of key nutritive tissues- by pairing quantitative and population genomics techniques with gene expression, epigenetics, and functional genetics approaches. This work will greatly enhance our understanding of if and how natural selection has shaped genome divergence between closely related species, and the consequences of this divergence for offspring health.

PI_NAMEs: COUGHLAN, JENNIFER M. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Candidate Disease Gene;candidate identification;Chromosome Mapping;Complex;Conflict (Psychology);Development;Developmental Process;Dissection;early onset;Embryo;Embryo Deaths;Epigenetic Process;epigenomics;Evolution;Functional disorder;Gene Expression;gene expression variation;Genes;Genetic;genetic approach;Genetic Models;genetic resource;Genetic study;Genome;genome resource;Genomic Imprinting;Genomics;Genotype;Health;Human;human disease;Hybrids;imprint;Inbreeding;Incidence;Knowledge;Mimulus;Molecular Genetics;Natural Selections;Nature;offspring;Organism;parental role;Parents;Pattern;Phenotype;Placenta;Plants;Play;Population;Process;reproductive;Resource Allocation;Role;Shapes;Source;stem;Study models;System;Techniques;Testing;Tissues;Transgenic Organisms;Work

PROJECT_TITLE: The Evolution of Genomic Imprinting and Strong Reproductive Isolation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Cannabis components, including non-psychoactive cannabidiol (CBD), ease pain and anxiety in people living with HIV infection and under antiretroviral treatment. In this program, we shall extend our preliminary findings from mice infected with chimeric HIV that CBD increases virus expression that in turn may exacerbate HIV neurocognitive impairment (HIV-NCI). In particular, we shall test the hypothesis that the effects of CBD upon HIV expression arise from its specific suppression of antiviral immune responses.

PI_NAMEs: BORJABAD, ALEJANDRA ;KELSCHENBACH, JENNIFER L;VOLSKY, DAVID J (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: adaptive immunity;Affect;antagonist;Anti-Inflammatory Agents;Anti-Retroviral Agents;Antigens;Antiinflammatory Effect;antiretroviral therapy;antiviral immunity;Anxiety;Apoptosis;Archives;Astrocytes;Basic Science;behavior test;Biochemical;Bioinformatics;Biological Assay;Brain;brain cell;Brain Diseases;brain dysfunction;brain tissue;Cannabidiol;Cannabinoids;Cannabis;CB2 knockout;Cell Lineage;Cell Separation;Cells;Chronic;chronic infection;CNR1 gene;CNR2 gene;Cognition Disorders;Critical Pathways;Detection;Disease;DNA;Dose;drug of abuse;Epigenetic Process;Evaluation;experience;Flow Cytometry;Frequencies;Gene Expression;Gene Expression Profiling;Genes;Hand;high risk;histone modification;HIV;HIV Infections;HIV Seropositivity;HIV-associated neurocognitive disorder;Hypermethylation;IL7 gene;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunologics;Immunosuppression;Impaired cognition;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Innate Immune Response;Interferon Receptor;Interferons;Joints;Knockout Mice;Learning;Lymphocyte;Macrophage;marijuana use;marijuana user;Measurement;Mediating;Medicine;Microglia;MicroRNAs;Modeling;Modification;Mononuclear;Mus;National NeuroAids Tissue Consortium;Neurocognitive Deficit;neuroinflammation;neuropathology;Neuropathy;Pain;pain relief;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phosphorylation;Poly I-C;Population;posttranscriptional;pre-clinical;pre-clinical research;programs;promoter;receptor;Research;Residual state;response;Role;Route;Science;Seminal fluid;Signal Pathway;single-cell RNA sequencing;Specificity;Stimulus;System;Systems Biology;Testing;Time;Tissues;transcriptome;transcriptome sequencing;transmission process;Viral;Virus

PROJECT_TITLE: Mechanism of Cannabidiol Effects on HIV Expression, Neuroinflammation, and HIV Cognitive Disease in Chronically-infected Immunocompetent Mice


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE We will use natural variation in fishes to identify genetic modifiers of disease and to discover of mechanisms by which some species are resilient to pathology. This data will be intersected with human genome wide association studies to study and generate animal models of human disease. The traits understudy have direct correlates to human disease, including skeletal, metabolic, and glomerular kidney disorders.

PI_NAMEs: DAANE, JACOB MICHAEL (contact)

PROJECT_TITLE: Phylogenomic mechanisms of trait evolution and resilience to disease

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: MIAMI

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Narrative  The goal of this research is to use Community-Based Participatory Research (CBPR) methods to develop and evaluate the acceptability, feasibility and preliminary evidence of efficacy of a culturally and developmentally adapted mindfulness-based intervention program for Latinx emerging adults engaging in Heavy Episodic Drinking (i.e., binge drinking). The proposed study has significant public health implications by contributing to translational efforts to reduce alcohol use-related disparities among Latinx emerging adults who would otherwise not seek treatment.

PI_NAMEs: HOSPITAL, MICHELLE MARIE (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;Adherence;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Attention;attentional control;behavioral health intervention;binge drinking;cohort;college;Communities;community based participatory research;contingency management;Criminal Justice;culturally appropriate intervention;Data;Development;Discrimination;Disparity;disparity reduction;drinking;Effectiveness;emerging adult;emotion regulation;Ensure;Epidemiology;ethnic minority;Ethnic Population;exercise intervention;experience;Female;Focus Groups;Foundations;Frequencies;Funding;Goals;Health;Health behavior;health disparity populations;health inequalities;Health Promotion;healthy lifestyle;Heavy Drinking;High Prevalence;high risk;High School Student;Hour;improved;Informal Social Control;informant;innovation;interest;Intervention;intervention program;intervention refinement;Interview;Latinx;Latinx population;Liver Cirrhosis;male;Methods;mindfulness;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Minority Groups;minority health disparity;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Personal Satisfaction;pilot trial;Population;Prevention;Process;programs;Protocols documentation;Public Health;racial minority;racial population;racism;Randomized;Recommendation;reduced alcohol use;Reporting;Research;Research Methodology;Resources;Risk;Sampling;Spanish;Stress;stress reduction;Structure;Substance Use Disorder;substance use treatment;Surface;System;Testing;Translations;treatment adherence;Underrepresented Minority;United States;Work;Yoga;Youth

PROJECT_TITLE: A Reinforced Mindfulness-Based Intervention to Reduce Problematic Drinking among Latinx Emerging Adults: Feasibility and Acceptability

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative  Parasitic protozoa are a major cause of global infectious diseases and thus, represent one of the most serious threats to public health. Among these are African trypanosomes, the causative agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent. Our proposed studies will provide an insight into control mechanisms of variant surface glycoprotein expression during the developmental program that leads to the establishment of infectious trypanosomes, which has the potential to expose new strategies to combat the diseases caused by these deadly parasites.

PI_NAMEs: TSCHUDI, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3' Splice Site;3' Untranslated Regions;Africa South of the Sahara;African;African Trypanosomiasis;Antigenic Variation;Biology;Blood;Blood Circulation;Cattle;Cells;Chronic;Code;combat;Communicable Diseases;Complex;coping;Development;differentiation in vitro;Disease;Dissection;Domestic Pig;Economic Development;Enhancers;Environment;Exposure to;Face;feeding;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;Human;Immune Evasion;In Vitro;inducible gene expression;Infection;Insect Vectors;insight;Instruction;Intercistronic Region;Investigation;Life;Life Cycle Stages;live cell imaging;Livestock;Membrane Glycoproteins;Messenger RNA;metacyclogenesis;Modeling;Molecular;Monitor;mRNA Expression;mRNA Precursor;mRNA Stability;nagana;news;novel;Output;Parasites;pathogen;Pharmaceutical Preparations;Play;Polyadenylation Pathway;Population;posttranscriptional;Production;programs;Proteins;Protozoa;Public Health;Regulation;Research;Resolution;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Salivary Glands;side effect;single-cell RNA sequencing;Site;Surface;System;telomere;Therapeutic;Time;time use;Tissues;Trans-Activators;Trans-Splicing;Transcript;transmission process;Trypanosoma;Trypanosoma brucei brucei;Tsetse Flies;Vaccines;Variant;vector;wasting

PROJECT_TITLE: Control of VSG pre-mRNA processing in infectious Trypanosoma brucei

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Opioids;Osteoarthritis;Pain Research;Patient Safety;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Chronic preoperative opioid use is associated with worse surgical outcomes in total knee arthroplasty. Tapering opioids preoperatively holds potential to improve outcomes for these patients, but high-quality evidence of efficacy is lacking, and the best approach to taper opioids in this setting is not known. This application will support an early-career investigator to develop and begin testing a preoperative opioid tapering intervention, which has the long-term potential to improve care in this very common operations.

PI_NAMEs: RIGGS, KEVIN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adherence;Adopted;Analgesics;Award;Behavior;behavior change;career;Caring;Characteristics;Chronic;chronic pain;Clinical;Clinical Pharmacists;clinical trial implementation;Clinical Trials;Clinical Trials Design;Complication;Control Groups;Data;Degenerative polyarthritis;Dependence;Dose;Education;education planning;Educational Curriculum;efficacy testing;efficacy trial;Evaluation;experience;functional restoration;functional status;Future;Goals;Health Services Research;Hyperalgesia;implementation outcomes;improved;improved outcome;Instruction;Intervention;K-Series Research Career Programs;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Literature;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;motivational enhancement therapy;multidisciplinary;non-cancer chronic pain;operation;Operative Surgical Procedures;Opioid;Opioid Receptor;opioid tapering;opioid use;Outcome;Outcome Assessment;Outcome Measure;Pain;Pain management;pain reduction;Participant;patient engagement;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Perioperative;Persons;Persuasive Communication;Pharmacists;Phase;Physicians;Pilot Projects;pilot trial;Positioning Attribute;post-operative rehabilitation;Postoperative Pain;Postoperative Period;Preparation;programs;Prospective Studies;Protocols documentation;Psychologist;Publishing;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Rehabilitation therapy;Replacement Arthroplasty;Research;Research Personnel;retention rate;Retrospective Studies;secondary outcome;skills;smoking cessation;surgery outcome;Telephone;Testing;therapy development;Training;Uncertainty;Visit

PROJECT_TITLE: Developing and Testing an Opioid Taper Intervention Before Total Knee Arthroplasty

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


PHR: PROJECT NARRATIVE Heart failure (HF) afflicts 6.5 million US adults and is associated with significant morbidity and mortality. Reverse remodeling and recovery of cardiac function has been reported in ~15% of patients with advanced HF. Fatty acid metabolism and more specifically sphingolipids play a pivotal role in the pathogenesis of HF. Understanding the factors and mechanisms associating FA metabolism with cardiac recovery could lead to the development of novel personalized therapies to improve outcomes in the greater HF population.

PI_NAMEs: TSELIOU, ELENI  (contact)

PROJECT_TERMS: Address;Adult;Affect;Amino Acids;Animal Model;Apoptosis;Area;Attention;Award;Basic Science;Binding Sites;Biochemical;Biology;Carbohydrates;Cardiac;Cardiac Myocytes;Cardiology;Cardiomyopathies;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career;career development;Cause of Death;Cell Aging;cell growth;cell motility;Cell Physiology;Cell Proliferation;Cellular biology;Ceramide glucosyltransferase;Ceramides;Cities;Clinical;Clinical Research;cohort;Collaborations;coping;Coupled;Data;Dependovirus;Development;Development Plans;Devices;Disease;Doctor of Philosophy;economic impact;Endocytosis;Environment;Equilibrium;Evaluation;Extramural Activities;Faculty;fatty acid metabolism;Fatty Acids;Fibrosis;flexibility;functional improvement;Funding;gene conservation;Gene Expression;Genes;Genetic Models;Glycolysis;glycosylation;Goals;hands-on learning;Health Sciences;Heart failure;heart function;Heart Hypertrophy;Histology;Human;Hypertrophy;Impairment;implantation;improved;improved outcome;In Vitro;Inflammation;insight;Insulin Resistance;Intracellular Transport;Junior Physician;Laboratories;left ventricular assist device;Link;lipidomics;Lipids;Liver;Mass Spectrum Analysis;Mediating;medical specialties;Mentors;Metabolic;metabolic phenotype;Metabolism;metabolomics;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;Myocardial tissue;Myocardium;novel;novel therapeutic intervention;novel therapeutics;overexpression;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathway interactions;Patients;personalized medicine;Phenotype;physician-scientist training program;Play;Population;prevent;Production;promoter;Publications;Pump;Recording of previous events;Records;Recovery;Reporting;Research;Research Ethics;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;response;Role;RXR;Scientist;Serum;Sodium Chloride;Source;Sphingolipids;Sphingomyelins;Sphingosine;Structure;Subgroup;symposium;Testing;Therapeutic Intervention;Time;Tissues;Training;Transcription Alteration;transcription factor;Transcriptional Regulation;transcriptomics;Transgenic Animals;Transgenic Model;Universities;Utah;Ventricular;Vocational Guidance;Writing

PROJECT_TITLE: The Role of Glycosyl Ceramides in Heart Failure and Recovery

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

PHR: Project Narrative Owing to the significant clinical and societal burden of pediatric FS and the lack of evidence-based treatment approaches, new strategies are needed for addressing pediatric FS that utilize novel treatment targets. This study will assess the feasibility of a multi-site trial assessing Retraining and Control Therapy (ReACT) for pediatric FS in preparation for a subsequent, fully powered efficacy trial.

PI_NAMEs: FOBIAN, AARON D (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: 18 year old;adaptive intervention;Address;Adherence;Adolescence;Adult;Aftercare;Alabama;Anxiety;arm;Awareness;Behavioral;behavioral clinical trial;Benchmarking;Child;Childhood;Clinic;Clinical;Clinical Treatment;Clinical Trials;clinically significant;Code;Cognitive;Cognitive Therapy;college;common symptom;Conscious;Data;Diagnosis;diaries;Dimensions;E-learning;effective therapy;efficacy trial;Electroencephalography;emerging adult;Enrollment;Epilepsy;Evidence based treatment;experience;Family;Family member;follow up assessment;follow-up;Frequencies;Fright;Functional Imaging;Future;Goals;Habits;Hearing;imaging study;improved;Individual;Intervention;Measures;medical schools;Medicine;meetings;mind/body;mindfulness;Moods;multi-site trial;Nervous System Disorder;novel;Parents;Participant;Patients;Pediatric Hospitals;Persons;Placebos;Preparation;prevent;Provider;Publishing;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;response;Schools;Seizures;Selective Serotonin Reuptake Inhibitor;Site;standard care;standard of care;Supportive care;Symptoms;targeted treatment;Techniques;Texas;Time;Training;transition to adulthood;treatment planning;Treatment Side Effects;Unconscious State;Universities;Videotape;web platform;web-based intervention;Work

PROJECT_TITLE: A multi-site feasibility clinical trial of Retraining and Control Therapy (ReACT), a mind and body treatment for pediatric functional seizures


NIH_SPENDING_CATS: Genetics

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE: mRNA localization has classically been studied in the context of embryology and neurobiology, but recent genome-wide assays have now determined that mRNA localization is a general feature of cell biology impacting many unexplored aspects of cellular regulation. The proposed project will elucidate novel mechanisms of mRNA localization and determine their impacts on protein production and development. By innovating high-resolution and genome-wide technologies, the project will leverage Caenorhabditis elegans as a robust model system for linking molecular mRNA dynamics to embryogenesis.

PI_NAMEs: OSBORNE NISHIMURA, ERIN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Biological Assay;Biological Models;Caenorhabditis elegans;Cell Differentiation process;cell growth regulation;Cell Shape;Cells;Cellular biology;Complex;Cytoplasm;Cytoplasmic Granules;Cytoskeleton;Databases;Development;Disease;Embryo;Embryology;Embryonic Development;Ensure;Exhibits;Family;Fertility;Funding;Gene Expression;Genetic Transcription;genome-wide;Genomics;Germ Lines;Human;innovation;Link;Locales;Malignant Neoplasms;Maternal Messenger RNA;member;Membrane;Messenger RNA;Modeling;Molecular;nano;Neurobiology;novel;Organism;Pattern;Phase;Physical condensation;Post-Transcriptional Regulation;Production;programs;Proteins;Regulation;Research;Resolution;RNA-Binding Proteins;Shapes;Signal Transduction;Specificity;Subcellular structure;Sum;Technology;Transcript;transcriptome;Translating;Translations;Work

PROJECT_TITLE: mRNA regulation, localization, and dynamics in C. elegans embryogenesis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The research project Transforming Kidney Care in the Emergency Department (ED) using Artificial Intel- ligence Driven Clinical Decision Support is to determine best-practice methods for incorporating artificial intelligence (AI)-derived insights into emergency care delivery. This investigation will use the iterative develop- ment and evaluation of an AI-driven clinical decision support (CDS) system to prevent or mitigate acute kidney injury (AKI) as a reference use-case. The proposed research aims to increase our understanding of human-AI interactions in the emergency care setting through the development and evaluation of a novel AI-driven deci- sion support system for kidney disease.

PI_NAMEs: HINSON, JEREMIAH STEPHEN (contact);KLEIN, EILI YA'AKOV

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Transforming Kidney Care in the Emergency Department using Artificial Intelligence Driven Clinical Decision Support

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Nearly one in four Veterans (1.6 million individuals) receiving care from the Veterans Health Administration has diabetes. The treatment of diabetic complications is integral to Veteran health care. There is growing evidence that the bone is negatively affected by diabetes. People with type 2 diabetes have a higher risk of hip fracture, worse fracture healing, and higher rates of death following fracture. Because of the serious consequences of osteoporosis and fracture, it is critical to understand the mechanisms of diabetic bone disease. Diabetes alters the fat within the bone marrow and may play a role in diabetic bone disease. Understanding how marrow fat affects the bones will provide insight into the mechanisms of diabetic bone disease and could lead to targeted preventive and therapeutic treatments. Further, this research will shape future investigations into diabetic bone disease and osteoporosis.

PI_NAMEs: KIM, TIFFANY YOUNGUN (contact)

PROJECT_TERMS: Address;Adipocytes;adult obesity;Affect;Anti-diabetic Drugs;bariatric surgery;Behavior;Biometry;bone;Bone Density;Bone Diseases;bone fracture repair;bone health;bone imaging;Bone Marrow;bone mass;bone quality;bone turnover;Caring;Cell Count;Clinical Investigator;Clinical Research;clinical translation;Complication;Complications of Diabetes Mellitus;Data;Death Rate;design;Diabetes Mellitus;diabetic bone disease;Differentiated Gene;Dual-Energy X-Ray Absorptiometry;economic cost;effective therapy;Enrollment;Epidemiology;experience;falls;Fatty acid glycerol esters;Flow Cytometry;Fracture;fracture risk;Funding;Future;Gastric Bypass;Gene Expression;glycemic control;Glycosylated hemoglobin A;Goals;Health;Healthcare;high risk;Hip Fractures;imaging modality;Impairment;improved;Individual;insight;Investigation;K-Series Research Career Programs;laboratory experience;Link;lipid biosynthesis;lipid metabolism;Magnetic Resonance Spectroscopy;Marrow;Measures;Medical;Medical Care Costs;Mentors;Mentorship;Mesenchymal Stem Cells;Metabolic;Metabolism;Methods;mortality risk;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteoporosis;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Physicians;Play;Porosity;Positioning Attribute;Postoperative Complications;Postoperative Period;preservation;Prevalence;Preventive;progenitor;programs;Prospective Studies;Prospective, cohort study;Radial;Radiology Specialty;Reporting;Research;Research Design;Research Personnel;Resolution;Role;Serum;Shapes;Site;skeletal;Skeleton;skills;spine bone structure;stem cells;Therapeutic;tibia;Trabecular Bone Score;Training;Unsaturated Fats;Veterans;Veterans Health Administration;X-Ray Computed Tomography

PROJECT_TITLE: Bone marrow fat and skeletal health in type 2 diabetes


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Memory T-cells are strongly implicated in the pathogenesis of Crohn’s disease (CD). We find that tissue resident memory (TRM) T-cells, a recently described population of memory T-cells, exhibiting a pathogenic profile are enriched in active CD. This proposal will define a role for CD4+ TRM in the pathogenesis of CD, which may lead to novel therapeutic targets in the treatment of CD.

PI_NAMEs: BISHU, SHRINIVAS  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Antigens;Biological Products;Biometry;Caring;Case Series;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;ChIP-seq;Chronic;Clinical Management;cohort;Colitis;comparison control;Crohn's disease;cytokine;Data;Dendritic Cells;Disease;Disease Outcome;Disease remission;drug development;dysbiosis;Economic Burden;economic cost;effective therapy;enteric dysbiosis;Exhibits;Genes;Gnotobiotic;Goals;gut dysbiosis;gut microbiota;Immune response;Immunohistochemistry;imprint;in vitro Assay;in vivo;Inflammatory;Interleukin-1 beta;Interleukin-10;Interleukin-15;interleukin-23;Intestines;knock-down;Link;Maintenance;Medical;Methods;microbial;microbiota;Morbidity - disease rate;Mucous Membrane;Mus;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Population;Production;Prognostic Marker;receptor;Recurrent disease;Regulation;Reporting;Residencies;RNA Interference;Role;Signal Pathway;Site;Small Interfering RNA;Source;Sphingosine-1-Phosphate Receptor;T cell therapy;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tissue resident memory T cell;Tissues;trafficking;Training;Transcription Repressor;Transcriptional Regulation;translational study;Up-Regulation;Validation;Zinc Fingers

PROJECT_TITLE: CD4+ Tissue resident memory T-cells in Crohnâs Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Cyclin-dependent kinase 6 (CDK6) is highly expressed in T-cell acute lymphoblastic leukemia. This study will explore the novel regulatory function of CDK6 in leukemia cell dissemination, an important contributor to patient relapse, morbidity and mortality. Our work may suggest novel therapeutic strategies for leukemia patients and develop a new prognostic marker for T-cell leukemia.

PI_NAMEs: WANG, HAIZHEN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute T Cell Leukemia;antagonist;anti-PD-L1;Antibodies;Apoptosis;Binding;Blood Platelets;c-myc Genes;cancer cell;cancer invasiveness;Cell Line;Cell Nucleus;Cell Proliferation;Cells;chemokine receptor;Clinical;cohort;Correlative Study;CXCR4 Receptors;Cyclin D1;cyclin D3;cyclin-dependent kinase 6;Cytoplasm;Disease Progression;Enzymes;Genetic Transcription;Glycolysis;Goals;Human;Immune Evasion;Immunohistochemistry;In Vitro;in vivo;Infiltration;inhibitor;Invaded;Isoenzymes;knock-down;Laboratories;leukemia;leukemia treatment;leukemia/lymphoma;Leukemic Cell;Malignant Neoplasms;Measures;Mediating;mimetics;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;mutant;Mutate;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Nuclear Translocation;Organ;overexpression;Patients;Phosphorylation;Phosphotransferases;Play;pre-clinical;preclinical study;prevent;Prognosis;prognostic;prognostic assays;Prognostic Marker;prognostic value;programmed cell death ligand 1;Promoter Regions;Protein Isoforms;Proteins;Pyruvate Kinase;Reactive Oxygen Species;relapse patients;Role;Site;Stains;Survival Rate;T-Cell Leukemia;T-Cell Lymphoma;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;translational study;Treatment Efficacy;Treatment Failure;treatment strategy;Work

PROJECT_TITLE: Novel functions of CDK6 in T-cell leukemia progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Rehabilitation;Social Determinants of Health;Stroke;Telehealth

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Elevated levels of sedentary behavior are prominent and persistent among stroke survivors and associated with poor cardiovascular and cardiometabolic health outcomes which elevate the risk for recurrent stroke. Engaging key stakeholders to adapt a promising post-stroke sedentary behavior intervention for remote delivery using telehealth will expand its potential reach. Further, findings from the pilot randomized controlled trial will enable future efficacy trials to advance the development of interventions that can reduce sedentary behavior to improve health outcomes after stroke.

PI_NAMEs: KRINGLE, EMILY  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acceleration;Acute;Adopted;Adult;Advanced Development;American;attentional control;Behavior;behavior change;Behavioral;behavioral clinical trial;Benchmarking;cardiometabolism;Cardiovascular system;care providers;career development;Chronic;Chronic Obstructive Pulmonary Disease;Chronic Phase;chronic stroke;Client satisfaction;clinical outcome measures;Cognitive;Collaborations;comorbidity;Control Groups;COVID-19 pandemic;Data;Data Collection;design;Development;Development Plans;Diabetes Mellitus;disability;effective intervention;efficacy trial;Elements;Ensure;Environment;Environmental Risk Factor;EuroQOL;experience;feasibility testing;Future;Goals;Health;Health behavior;Health Promotion;health related quality of life;Heart Diseases;Home;Hour;Hypertension;Impaired cognition;Impairment;improved;Intervention;Interview;Knowledge;Kringles;Leadership;Learning;lifestyle intervention;Measurement;Mediator;Medical;Mental Depression;Mentors;Mentorship;Methods;Modeling;Monitor;Motor;Neurological disability;Outcome;Participant;patient oriented research;Personal Satisfaction;Persons;physical impairment;Pilot Projects;poor health outcome;Positioning Attribute;post stroke;Preparation;Problem Solving;Procedures;Process;programs;Protocols documentation;Qualitative Research;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrence;Rehabilitation therapy;remote delivery;remote intervention;Research;Research Methodology;Research Personnel;Residual state;Risk;Role;Sampling;Schedule;Science;sedentary lifestyle;Self Assessment;Self Efficacy;Senior Scientist;Sensory;Severities;sex;skills;social;social influence;Social support;Stroke;stroke risk;stroke survivor;telehealth;telerehabilitation;tertiary prevention;Testing;theories;therapy design;therapy development;Time;Training;Transportation;Treatment Protocols;Underserved Population;videoconference;Vision;Work

PROJECT_TITLE: teleABLE: Adapting a Behavioral Activation-Based Intervention to Reduce Post-Stroke Sedentary Behavior Using Telehealth

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Kidney Disease;Patient Safety;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: ENDOTHEIA, INC.

ORG_STATE: TN

PHR: Narrative: Public Health Relevance Of the 3.5 million Americans who suffer from kidney stones each year, 230,000 have large stone volumes that require either invasive surgery, or long-duration endoscopy which incurs high complication rates. To remove stones faster, we propose a new device that transforms almost instantaneously from an endoscope to a steer- able catheter with a large open lumen for suctioning out stone fragments. Success in this research will re- duce operation times, improve stone-free rates, and make many more patients candidates for minimally invasive ureteroscopy.

PI_NAMEs: GAFFORD, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TITLE: Breaking the Scope Port Size Barrier: A New Kind of Endoscope that Removes Large Kidney Stones Rapidly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(90)B]


ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Our gut microbes have many well-established effects on our health, but many of the most common gut microbes are only distantly related to typical laboratory model organisms. The proposed research develops quantitative, data-rich approaches to understand how these microbes grow, behave, and interact in different environments. In the future, this line of research could both improve our ability to interpret case-control studies of the microbiome, and lead to more precise, safer therapies that target our microbiome to improve health.

PI_NAMEs: BRADLEY, PATRICK JOSEPH (contact)

PROJECT_TITLE: Interrogating function, regulation, and interactions in a clade of prevalent human gut microbes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Using data drawn from the Adolescent Behavior and Cognitive Development (ABCD) study, this longitudinal study will examine the individual and joint contributions of adverse childhood events and community environments (ACEs) and genetic variation in delay discounting (DD) on the development of DD and subsequent substance use. The proposed study will be one of the most comprehensive investigations of the contextual and genetic determinants of the unfolding of DD across the adolescent years. Findings have the potential to inform the development of novel preventions and interventions aimed at improving DD and negative sequelae.

PI_NAMEs: FELTON, JULIA W;MAHER, BRION S;RABINOWITZ, JILL ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Acceleration;Acute;Address;Adolescence;Adolescent;Adolescent Behavior;Adult;adverse childhood events;Age;aged;alcohol use disorder;Behavior;Child;Child Development;Childhood;Choice Behavior;Chronic;Clinical;cognitive development;Communities;cost effective;COVID-19;COVID-19 pandemic;critical developmental period;Data;Decision Making;Development;Dimensions;Disadvantaged;discounting;Environment;environmental stressor;Etiology;executive function;experience;Exposure to;externalizing behavior;Frequencies;Future;Genetic;Genetic Determinism;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Health;health goals;health inequalities;Heritability;improved;Individual;insight;Intervention;Investigation;Joints;Length;life span;Link;Literature;longitudinal dataset;Longitudinal Studies;Measures;Mediating;meetings;Mission;Modeling;modifiable risk;National Institute of Drug Abuse;novel;Outcome;Pathway interactions;Pattern;PhenX Toolkit;polygenic risk score;Poverty;preference;Prevention;Prevention approach;Process;Public Health;reduced substance use;repository;Research;Resources;Rewards;Risk;Risk Behaviors;Risk Factors;Sampling;Severities;Shapes;socioeconomic disadvantage;Structure;substance misuse;substance use;Substance Use Disorder;substance use prevention;Sum;Symptoms;System;Taxes;Testing;Time;timeline;trait;Trauma;trauma exposure;Youth

PROJECT_TITLE: An Examination of the Joint Contributions of Socioeconomic Disadvantage, Genetics, and COVID-19 on the Development of Delay Discounting and Substance Use Across Adolescence


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed project seeks to establish a new ultrasensitive detection system and obtain reliable exosomal biomarkers for the early detection of type 1 diabetes. To address current technological barriers in exosome biology, the project will create an innovative integrated system on a chip for the high throughput screening, identification, and detection of islet-derived exosomal markers in type 1 diabetes.

PI_NAMEs: GAGLIA, JASON ;GUO, FENG ;LEE, LUKE P. (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acoustics;Address;Affect;American;Autoimmune;Autoimmune Diseases;Benchmarking;Beta Cell;Biological Assay;Biological Markers;Biology;biomarker discovery;Cells;Clinical;Clinical Trials;Detection;detection platform;Development;Devices;Diabetes Mellitus;Diagnosis;Disease;DNA;early detection biomarkers;Early Diagnosis;Electronics;Engineering;Environment;exosome;experimental study;Expert Systems;extracellular vesicles;Functional disorder;Genetic Markers;high throughput screening;Hour;improved;Inflammation;innovation;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;Intervention;islet;islet cell antibody;Islets of Langerhans;Label;Machine Learning;MALDI-TOF Mass Spectrometry;Membrane;Membrane Proteins;Metabolic Marker;Methods;Microfluidics;microRNA biomarkers;MicroRNAs;Monitor;Nature;Nucleic Acids;Optics;Outcome;Pancreatectomy;Patients;Persons;Phase;photonics;Plasma;pre-clinical;protein biomarkers;Proteins;Research Personnel;response biomarker;RNA;Sampling;sensor;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Standardization;Structure of beta Cell of islet;System;Systems Analysis;Systems Integration;Technology;treatment response;United States;Work

PROJECT_TITLE: Early detection of type 1 diabetes via Exosome Technology with Optoelectronics Lab-on-chip: EXTOL


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Relative to their heterosexual peers, sexual minority women are at heightened risk of developing an eating disorder, which has the highest mortality rate of all psychiatric illnesses. The limited knowledge pertaining to the unique risk factors that contribute to eating disorders among sexual minority women prevents intervention efforts from effectively reducing eating disorder risk in this population and has limited the community resources to rectify the disparity. In partnership with community stakeholders, this proposal will identify salient social and environmental risk factors that contribute to eating disorder behaviors in diverse sexual minority women, which will inform targeted interventions and community resources to diminish disparities in this group.

PI_NAMEs: SIMONE, MELISSA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Affect;Age;Appearance;Award;Behavior;Behavior Disorders;career;career development;case control;Case/Control Studies;clinical development;cognitive interview;Communities;community advisory board;community engaged research;community engagement;community partners;Data;Data Collection;Data Set;Death Rate;decision research;design;diaries;Discrimination;disorder prevention;disorder risk;Disparity;Eating Disorders;Ecological momentary assessment;Emotions;Environmental Risk Factor;ethnic diversity;ethnic identity;Ethnic Origin;Event;experience;Foundations;Funding;gender minority group;Goals;Guidelines;Health;Health Disparities Research;health equity;Health equity research;Heterogeneity;Heterosexuals;high risk;Homophobia;improved;Individual;innovation;Intervention;Knowledge;Lesbian;Link;Literature;Lived experience;Measures;member;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Minority;minority stress;Modeling;multidisciplinary;novel;Outcome;Pathway interactions;Pattern;peer;perceived discrimination;Phase;Population;Population Surveillance;Positioning Attribute;pressure;prevent;Prevention;Prevention Guidelines;Process;programs;Property;Protocols documentation;Psychometrics;queer;Race;racial disparity;racial diversity;racial identity;Reduce health disparities;reduced food intake;Research;Research Methodology;Research Personnel;research study;Resource-limited setting;Resources;response;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Secure;Sex Behavior;sexual identity;sexual minority;sexual minority community;sexual minority group;sexual minority health;sexual minority men;sexual minority women;Shapes;social;social culture;social factors;Social support;Stress;stressor;Structure;Subgroup;Symptoms;Testing;Thinking;Time;tool;Training;treatment guidelines;United States National Institutes of Health;Woman;young adult

PROJECT_TITLE: Population-Specific Eating Disorder Risk Factors in Sexual Minority Women


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative The proposed research is relevant to public health because it focuses on defining mechanisms of how the Kaposi's sarcoma-associated herpesvirus (KSHV) maintains latency in tumor cells. Because latency control is fundamental to the viral life cycle, our research significantly impacts studies in AIDS-defining malignancies caused by KSHV including primary effusion lymphoma.

PI_NAMEs: MANZANO, MARK  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;B lymphoid malignancy;B-Cell Lymphomas;Binding;Biology;Cell Line;Cell Survival;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Data;DNA biosynthesis;Epigenetic Process;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Genome;Goals;Hand;histone modification;HIV/AIDS;Human Herpesvirus 8;Kaposi Sarcoma;knock-down;latent gene expression;Left;Length;Life Cycle Stages;Lymphoma;Lymphoma cell;Lytic;Lytic Phase;lytic replication;Maintenance;Malignant Neoplasms;Modeling;Mutation;neoplastic cell;Oncogenic;Patients;primary effusion lymphoma;programs;Proliferating;Proteins;Public Health;reactivation from latency;recruit;Replication Origin;Research;RNA;RNA replication;Role;Site;Transcript;transcriptome;transcriptome sequencing;tumor;Untranslated RNA;Viral;viral DNA;Viral Genes;Viral Genome;Virus;Virus Latency;Work

PROJECT_TITLE: Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Infectious Diseases;Liver Disease;Microbiome;Substance Misuse

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Alcoholic Hepatitis (AH) is a severe inflammatory disease that causes significant mortality among patients with Alcohol-related liver disease. In this project, we will investigate how the innate immune system and the micro- and myco-biome interact via a family of genes called the C-type lectin receptors (CTLs) to increase inflammation and disease severity among AH patients. The results of this project will expand our understanding of CTLs and immune surveillance, and provide new therapeutic targets for treatment of AH.

PI_NAMEs: KIM, ADAM  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acute;Address;Affect;Agonist;Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;ATAC-seq;Bacteria;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Blood;Blood Circulation;C Type Lectin Receptors;C-Type Lectins;career development;CD14 gene;Cell membrane;cell type;Cells;Chromatin;Chromatin Structure;chronic alcohol ingestion;Circulation;Clinical;Clinical Immunology;Complement;cytokine;Data;data analysis pipeline;dectin 1;Dedications;Dendritic Cells;Development Plans;Disease;disease phenotype;Disease Progression;Elements;Ethanol Metabolism;experimental study;Extravasation;Faculty;Family;FCGR3B gene;Focus Groups;Functional disorder;Fungal Components;fungus;Future;Gene Cluster;Gene Expression;Gene Expression Regulation;Gene Family;Genes;Genetic Transcription;Genome;Gram-Negative Bacteria;gut microbes;gut microbiome;gut microbiota;Hypersensitivity;Immune;Immune response;Immune system;Immunologic Surveillance;immunological diversity;Immunology;immunoregulation;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;inflammatory modulation;Innate Immune Response;Innate Immune System;Leadership;Learning;Lectin Receptors;Ligands;Lipopolysaccharides;Liver;liver inflammation;liver injury;machine learning algorithm;Measurement;Measures;Mediating;member;Mentors;Microbe;microbial;microbial products;microorganism interaction;Molecular;Monitor;monocyte;Morbidity - disease rate;mortality;mouse dectin-2;mouse model;mycobiome;Myelogenous;new therapeutic target;particle;pathogen;pathogenic bacteria;pathogenic fungus;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Positioning Attribute;Postdoctoral Fellow;prevent;receptor expression;Receptor Gene;Receptor Signaling;Regulation;Research;response;Ribosomal RNA;Role;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;skills;Stimulus;Technology;Testing;therapeutic target;TLR4 gene;Toll-like receptors;tool;transcription factor;Transcriptional Regulation;Transposase;Up-Regulation;Variant;Virus;Work

PROJECT_TITLE: C-Type Lectins and Immune Surveillance in ALD

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Opioids;Pain Research;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: For unknown reasons, women suffer from many pain conditions to a greater degree than men. Our studies propose to identify a stress-related neuroendocrine link to changes in nociceptors providing a basis for female- selective pain syndromes. These studies may unravel mechanisms for therapeutic interventions allowing improved therapy of functional pain syndromes in women.

PI_NAMEs: NAVRATILOVA, EDITA ;NEUGEBAUER, VOLKER ;PORRECA, FRANK  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: acute stress;Afferent Neurons;Age;Agonist;allodynia;Anatomy;Animals;Antibodies;behavioral study;Biological;Brain region;central sensitization;chronic pain;Chronic stress;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;dopaminergic neuron;Down-Regulation;Dynorphins;Electrophysiology (science);Equilibrium;Event;experience;Female;Fibromyalgia;Frequencies;Future;ganglion cell;Genetic;genetic manipulation;Genetic Transcription;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;imaging study;improved;Injury;innovation;Irritable Bowel Syndrome;Irritants;kappa opioid receptors;Knowledge;lactotroph;Link;male;Mediating;men;Migraine;Modeling;Mus;neural;neuroadaptation;neurochemistry;Neurosecretory Systems;Nociception;Nociceptors;novel;Opioid;Opioid agonist;Opioid Antagonist;overexpression;Pain;Pain Disorder;Pain Free;Pathologic;Patients;Peripheral;Persistent pain;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phase;Physiological;Physiology;Pituitary Gland;pre-clinical;Prevalence;prevent;Prevention;Prolactin;Prolactin Receptor;Protein Isoforms;Receptor Activation;receptor expression;Receptor Signaling;reproductive;restraint stress;Risk;risk prediction;Rodent;Rodent Model;Role;selective expression;sexual dimorphism;Signal Transduction;Spinal Ganglia;Stimulus;Stress;Structure of nucleus infundibularis hypothalami;Structure of trigeminal ganglion;Synapses;Syndrome;Temporomandibular Joint Disorders;Testing;Therapeutic Intervention;triptans;TRPA channel;Woman;Women's prevalence;women's treatment

PROJECT_TITLE: A prolactin-mediated neuroendocrine link between stress-induced latent sensitization and female-selective pain

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: RELEVANCE (See instructions): The present project constitutes a multidisciplinary effort combining cutting-edge experimental and  computational techniques to elucidate the impact that evolution has on the neural circuit mechanisms  contributing to learning. Understanding the neural basis of learning will have implications for human  health, as several mental illnesses, such as schizophrenia, parkinson and autism, have been associated  with the altered use of priors.

PI_NAMEs: JAZAYERI, MEHRDAD  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Acceleration;Animal Behavior;Animals;Area;autism spectrum disorder;Behavior;Behavioral;Brain;Cognition;Cognitive;cognitive task;Computational Technique;Corpus striatum structure;Decision Making;Development;Endowment;Environment;Event;Evolution;Exhibits;experimental study;fitness;Goals;Health;Human;Instruction;Laboratories;Learning;learning network;Mental disorders;Modeling;multidisciplinary;Nature;neural;neural circuit;Neural Network Simulation;neuromechanism;Neuronal Plasticity;next generation;optogenetics;Outcome;Parkinson Disease;Performance;Population;prevent;Process;programs;Rattus;recurrent neural network;Rewards;Role;scaffold;Schizophrenia;Shapes;Site;Source;statistics;Synaptic plasticity;System;Testing;Ticks;tool;Training;Work

PROJECT_TITLE: CRCNS: Circuit mechanisms of priors and learning during decision making