NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Bone-metastatic lesions will develop in approximately 65-75% of patients with metastatic breast cancer and are associated with high morbidity and mortality. Despite our limited understanding of how breast-to-bone metastases form, the recent emergence of metabolic adaptation as a critical factor in metastasis is a promising development. This work will fully examine the putative intrinsic and extrinsic mechanisms by which glutamine metabolism may promote breast-to-bone metastasis as well as the possibility of using pre-existing cancer therapies targeting glutamine metabolism to ameliorate bone metastatic burden in breast cancer.

PI_NAMEs: KARNO, BREELYN A (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 4T1;aggressive breast cancer;bone;Bone neoplasms;Breast;Breast Cancer Cell;Breast Cancer cell line;CASP3 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Cycle Inhibition;Cell Cycle Progression;Cells;checkpoint inhibition;Clinical;Coculture Techniques;CRISPR/Cas technology;Dasatinib;Data;Development;Endothelial Cells;Enzymes;Exhibits;Flow Cytometry;follow-up;functional loss;Gene Modified;Genes;Genetic;Glutamates;Glutaminase;Glutamine;Homing;In Vitro;in vivo;Injections;Knock-out;Knockout Mice;Link;Malignant Bone Neoplasm;Malignant Breast Neoplasm;MDA MB 231;Metabolic;Metabolism;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Nutritional;osteoblast differentiation;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteolysis;Osteolytic;overexpression;parathyroid hormone-related protein;Patients;pharmacologic;Phenotype;Population;Production;progenitor;Proteins;Quercetin;Research;senescence;senolytics;Signal Transduction;Stains;targeted cancer therapy;tartrate-resistant acid phosphatase;Testing;Therapeutic;Tissue Stains;Tissues;TNFSF11 gene;transcriptome sequencing;tumor;Tumor Burden;Up-Regulation;uptake;vector;Woman;Work

PROJECT_TITLE: Elucidating Glutamine Metabolism in Breast to Bone Metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Patient Safety

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Despite technological improvements and strategic initiatives (e.g., hospital outcomes reporting), major complications following general thoracic and adult cardiac surgery remain common, vary by hospital, increase the risk of mortality and add considerably to healthcare expenditures. Emerging data linking surgeon operative performance, encompassing technical and non-technical (e.g., communication, decision-making) skills, with patient outcomes after non-cardiac surgery reveals that surgical technical skills are necessary yet alone are insufficient for achieving high performance. This study, leveraging a partnership with a professional sport association (given their pioneering work in advancing data-driven performance parameters for athletes) and our expertise conducting real cardiothoracic surgery video-based ratings of operative performance, has the following aims: (1) Develop a multidomain cardiothoracic surgeon operative performance index; (2) Identify biomarkers associated with a surgeon’s operative performance; and (3) Qualitatively assess determinants of a surgeon’s optimal operative performance.

PI_NAMEs: DEARANI, JOSEPH A;LIKOSKY, DONALD S (contact);YULE, STEVEN

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Accounting;Adoption;Adult;Air;Anastomosis - action;Atrial Fibrillation;Awareness;Biological Markers;biomarker identification;Cardiac;Cardiac Surgery procedures;Cardiopulmonary Bypass;career;Chest;Clinical Research;Cognitive;cognitive load;cognitive task;Communication;Data;Data Analytics;Decision Making;Development;digital;digital technology;Discipline;emotion regulation;ergonomics;evidence base;Expenditure;Faculty;Fatigue;Goals;Health Expenditures;Heart Arrest;heart rate variability;high risk;Hospitals;Human;implementation research;improved;indexing;Inpatients;Internships;Interview;learning strategy;Link;Measures;Medical;Monitor;Morbidity - disease rate;mortality;mortality risk;Motion;Multicenter Studies;National Heart, Lung, and Blood Institute;operation;Operative Surgical Procedures;Outcome;Pain;Participant;Patient risk;Patient Self-Report;Patient-Focused Outcomes;Performance;Personal Satisfaction;Physiological;Physiology;Procedures;Program Development;Protocols documentation;Proxy;psychologic;Questionnaires;Reporting;Research Personnel;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;skills;Sports;Structure;Surgeon;surgery outcome;Taxonomy;Technical Expertise;Technology;Tennis;Time;tool;Training;unsupervised learning;Video Games;Work

PROJECT_TITLE: Surgeons as High-Performance Athletes: Applying Player Development Strategies from Professional Sport to Enhance Surgical Performance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research addresses a crucial gap in the understanding of two, interconnected crises among U.S. adolescents – intimate partner violence (IPV) and depression – by conducting longitudinal, person-centered analyses to identify distinct patterns of IPV experiences and depression symptom trajectories during the transition from mid-adolescence to young adulthood. Results will for the first time elucidate several key findings: 1) types and extent to which adolescents experience IPV; 2) longevity and degree to which adolescents who experience IPV also experience depression symptoms; 3) effect of adolescents’ IPV experiences on depression symptom trajectories into young adulthood; 4) how these findings contrast by sociodemographic and background indicators. Findings will identify adolescents with outreach needs for IPV and/or depression support, and precisely when the need is most dire.

PI_NAMEs: AKANDE, MORAYO  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Adult;Adverse effects;Affect;Age;aged;Aggressive behavior;Alcohol consumption;Anxiety;Centers for Disease Control and Prevention (U.S.);Child Behavior;child depression;Child Development;Child Health;coping mechanism;Cross-Sectional Studies;Data;Data Set;Depressed mood;depressive symptoms;Development;Education;emotional abuse;Epidemic;ethnic minority;Ethnic Origin;Etiology;Exhibits;experience;externalizing behavior;Feeling;Feeling hopeless;Feeling suicidal;Female;Funding;Future;gender minority;Health;Health Disparities Research;Heterogeneity;Household;improved;Impulsivity;Individual;individual variation;Intervention;intimate partner violence;Knowledge;Lesbian Gay Bisexual Transgender Queer;Life Cycle Stages;Link;Literature;Longevity;male;Measures;Mental Depression;Mental Health;Modeling;National Institute of Child Health and Human Development;National Institute of Mental Health;next generation;Outcome;outreach;Participant;Pattern;person centered;Personal Satisfaction;physical abuse;Play;Policies;Populations at Risk;post-traumatic stress;Predisposition;Prevalence;psychologic;Public Health;Race;racial minority;Reporting;Research;Research Priority;research study;Risk;Risk Factors;Sampling;Self-Injurious Behavior;Severities;sex;Sex Differences;Sex Orientation;Sexual abuse;sexual minority;single episode major depressive disorder;sociodemographics;Strategic Planning;Structure;Subgroup;substance use;Time;transition to adulthood;United States National Institutes of Health;Variant;verbal;Verbally abusive behavior;violence exposure;Withdrawal;Work;young adult

PROJECT_TITLE: Intimate Partner Violence and Depression Trajectories from mid-Adolescence to Young Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Disorders of gut-brain interaction (DGBIs) like irritable bowel syndrome (IBS) collectively affect around 15% of US adults. Patients suffering from DGBIs suffer significant disability and have few successful therapeutic options. Dietary modifications are the first line therapies and have been most successful at alleviating symptoms. One such dietary modification is the elimination of FODMAPs. FODMAPs are highly osmotically active, driving luminal volume shifts in the small bowel, but mechanistic understanding of osmotic signal transduction remains unclear, and how it affects cellular, multicellular, and systemic processes to alter GI physiology remains unknown. Our lab discovered a population of enteroendocrine cells (EECs) that sense non-nutritive stimuli such as mechanical force, thereby opening the door for EECs to be sensors of other non- nutritive stimuli, such as osmoles. In this proposal, we seek to uncover the role of EECs in sensing osmotic stimuli and how these pathways alter signal molecule release and GI motility. This knowledge may pinpoint targets for the treatment of DGBIs.

PI_NAMEs: BELLAMPALLI, SHREYA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adult;Affect;Anions;antagonist;Automobile Driving;Calcium;Calcium Signaling;Cell Communication;Cell model;Cells;cellular transduction;Chemicals;Cholecystokinin;Clinical;clinical training;clinically relevant;Collaborations;Colon;Cyclic AMP;Cytoplasm;Data;Diarrhea;Diet;Diet Modification;Dietary Component;disability;disorders of gut-brain interaction;Doctor of Philosophy;Eating;Electrophysiology (science);Enterochromaffin Cells;Enteroendocrine Cell;Environment;Epithelial Cells;Epithelium;Exhibits;Exposure to;extracellular;Fermentation;Food;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal Motility;Gastrointestinal Physiology;Gastrointestinal tract structure;ghrelin;glucagon-like peptide 1;Goals;Ingestion;innovation;insight;Irritable Bowel Syndrome;Kidney;Knowledge;L Cells;Learning;Literature;live cell imaging;Location;mechanical force;mechanical signal;Molecular;Monosaccharides;Motility;Mus;Neurotensin;Nutrient;Oligonucleotides;Oral;Organoids;Osmolalities;Osmolar Concentration;Osmosis;Pain;Pathway interactions;Patients;Physicians;Physiological;Physiology;Piezo 2 ion channel;polyol;Population;Process;Proteins;receptor;Receptor Activation;Receptor Cell;reduce symptoms;Regulation;Renal tubule structure;Research Activity;response;Role;Scientist;sensor;Sensory;Serotonin;Serum;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;skills;Small Intestines;Specific qualifier value;Speed;Stimulus;Stomach;Surgeon;Symptoms;Techniques;Testing;Therapeutic;Time;Training;Transgenic Organisms;Tubular formation;Visceral;Water;Work

PROJECT_TITLE: Mechanisms of osmosensing in GI enteroendocrine cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


PHR: PROJECT NARRATIVE Pleural mesothelial cells are often not included in the discussion of cells involved in lung injury and repair, largely because their role has yet to be thoroughly investigated. Intriguingly, these cells appear to be activated in both conditions. This project will study the involvement of pleural mesothelial cells in injury, repair, and regeneration and will investigate their direct impact on specific cell types in the lung to determine their contribution as pathogenic or reparative.

PI_NAMEs: GILBERT, RACHEL  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adult;Age;aging related disease;Alveolar;Alveolus;Area;Behavior;Bleomycin;Cell Lineage;cell motility;Cell Physiology;cell population study;cell type;Cells;Chemicals;chronic respiratory disease;Clinical;Coculture Techniques;Collecting Cell;Confusion;Data;Data Set;Deposition;Differentiation and Growth;Disease;Disease Progression;Distant;Environment;Epithelium;Equilibrium;Exclusion;experimental study;Fetal Development;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Genetic Transcription;Genomics;Goals;Growth;Human;idiopathic pulmonary fibrosis;improved;indium-bleomycin;injured;Injury;injury and repair;Invaded;Investigation;juvenile animal;knowledge base;Label;life span;Lobe;Location;Lung;Lung Capacity;lung development;Lung Diseases;lung injury;lung regeneration;lung repair;Mediation;Mediator;Mesenchyme;Mesothelial Cell;Mesothelium;migration;Modeling;mouse model;Mus;Myofibroblast;Natural regeneration;novel;Organ;Organoids;Pathogenicity;Pathway interactions;Play;Pleural;Pleural Mesothelial Cell;Pneumonectomy;Pulmonary Fibrosis;pulmonary function;receptor;recruit;regeneration model;regenerative;regenerative repair;repaired;Reporter;response;response to injury;Role;Signal Transduction;single-cell RNA sequencing;Site;Stains;Structure of parenchyma of lung;Surface;Techniques;Time;tissue injury;Tissue Model;tissue regeneration;tissue repair;Tissues;Visualization;WNT Signaling Pathway;Work

PROJECT_TITLE: The role of pleural mesothelium in lung injury, repair, and regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Twenty years after the World Trade Center (WTC) terrorist attack on September 11, 2001, there is a rapid increase in the number of diagnoses and mortality of women’s breast cancer and other cancers. To improve cancer surveillance and treatment for WTC cancers, we propose to conduct integrated analyses of cancer risk and mortality and associated risk factors in WTC survivors enrolled at the New York City Health and Hospitals WTC Environmental Health Center (NYC H+H WTC EHC), Williams Street Clinic and National Provider Network, three CDC/NIOSH-designated treatment and surveillance programs for exposed community members (i.e. survivors). We propose to integrate data on WTC exposures and other risk factors and test their associations with the breast cancer characteristics, and survival using individual-level patient exposure, clinical, outcome data available at the Survivor Data Center (SDC) which hosts the pan-cancer database.

PI_NAMEs: ARSLAN, ALAN A.;SHAO, YONGZHAO  (contact)

PROGRAM_OFFICER_NAME: YIIN, JAMES

PROJECT_TITLE: Integrated analysis of cancer risk and mortality in WTC survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 LEE (52)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_STATE: TN

PHR: PROJECT NARRATIVE We aim to construct a three-dimensional molecular atlas to study the progression trajectories of colorectal cancer (CRC) across different ages of onset. We will employ multimodal imaging technologies to characterize the genetic, transcriptomic, metabolomic, microbial, and architectural features of CRC. Our three-dimensional mapping of precancer-to-cancer transitions of each tumor category will elucidate cellular and molecular factors contributing to the rise of earlier onset of cancer.

PI_NAMEs: LAU, KEN S (contact);SPRAGGINS, JEFFREY M

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Advocate;age group;Age of Onset;analytical tool;anti-cancer research;Antibiotics;Architecture;Artificial Intelligence;Atlases;Biology;Biometry;cancer diagnosis;Cancer Etiology;Cancerous;carcinogenicity;Categories;Cells;Cellular Metabolic Process;Cessation of life;Clinical;Clonality;Colorectal;Colorectal Cancer;Communities;Copy Number Polymorphism;Data;Data Analyses;Data Coordinating Center;data integration;data modalities;Data Set;demographics;Detection;Diagnosis;Dimensions;early onset;early onset colorectal cancer;Ensure;Epidemiologist;Epidemiology;Exhibits;exome sequencing;Gastroenterologist;gastrointestinal epithelium;Genetic;genomic profiling;Goals;Health;Histologic;histological image;Human;Image;Imaging technology;Immunofluorescence Immunologic;Immunofluorescence Microscopy;improved;In Situ;Incidence;indexing;insight;Lead;Life Style;Machine Learning;Malignant Neoplasms;malignant state;Maps;mass spectrometric imaging;Measures;Metabolic;metabolomics;Microbe;microbial;microbiome;Microsatellite Instability;Microsatellite Repeats;microscopic imaging;Modality;Modeling;Molecular;molecular subtypes;Multimodal Imaging;multimodality;multiple omics;Mutation;Neighborhoods;nutrition;Obesity;Onset of illness;Outcome;Pathologist;Pathology;patient population;Patients;Population Heterogeneity;premalignant;Premalignant Cell;programs;Publications;Research;Research Personnel;Resected;Risk Factors;scaffold;screening;Signal Transduction;single-cell RNA sequencing;socioeconomics;Structure;success;Surgeon;System;Technology;three-dimensional visualization;Tissues;transcriptomics;tumor;tumor microenvironment;Tumor Subtype;tumor-immune system interactions;United States;Work

PROJECT_TITLE: A Multimodal 3D Atlas of Colorectal Cancer Across Ages of Onset

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: The proposed research will inves1gate brain circuits involved in ac1ve vision (circuits that link visual mo1on percep1on and gaze shi:s). This research should provide informa1on relevant to the treatment of disorders in which visual mo1on processing is compromised, such as dyslexia and schizophrenia and may provide insight into the use of eye tracking as a tool for medical diagnoses and/or eye movement disorders such as nystagmus, strabismus, and amblyopia.

PI_NAMEs: BOONE, HOWARD CHASE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: active vision;Address;Affect;Amblyopia;Animals;area striata;awake;Brain;Calcium Signaling;Cell Nucleus;cell type;Cells;Code;Darkness;Dendrites;Diagnosis;Disease;Dyslexia;Electron Microscopy;Enterobacteria phage P1 Cre recombinase;Environment;Exhibits;Eye Movements;Felis catus;Fiber Optics;Fluorescence;fluorescence imaging;Frequencies;gaze;Glutamates;Goals;Head;Image;In Vitro;in vivo;Individual;Injections;insight;Knowledge;Lasers;Light;Link;Medical;Methods;Modeling;Morphology;Motion;Movement;Mus;Neurons;Nose;Ocular Motility Disorders;Opsin;optogenetics;Parvalbumins;Pathologic Nystagmus;Pathway interactions;Pattern;Photic Stimulation;Physiologic pulse;preference;Presynaptic Terminals;Probability;Property;Protocols documentation;Pulvinar structure;rabies viral tracing;RBP4 gene;Reaction;Reflex action;Reporter;Research;response;Retina;Retinal Ganglion Cells;Role;Running;Saccades;Schizophrenia;Shapes;Signal Transduction;Simplexvirus;Source;Speed;Stimulus;Strabismus;Structure;Synapses;Testing;Thalamic structure;tool;two-photon;Viral;Virus;Vision;Visual;Visual Fields;Visual Motion;visual stimulus;visual tracking;Whole-Cell Recordings

PROJECT_TITLE: The Influence of the Pretectum on the Pulvinar Nucleus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


PHR: PROJECT NARRATIVE Modification of T cell metabolic pathways offers a unique way to treat inflammatory diseases. Mitochondrial fatty acid synthesis (mtFAS) is a metabolic pathway with little known about its function in T cells. This study will investigate the role of mtFAS gene Mecr in T cell function and metabolism to uncover new biology and a possible unique target to treat inflammatory diseases.

PI_NAMEs: STEINER, KAYLEE KRISTAL (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acyl Carrier Protein;aerobic glycolysis;Affect;Anti-Inflammatory Agents;Apoptosis;Autoimmune Diseases;Biogenesis;Biology;CD4 Positive T Lymphocytes;Cell Death;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Citric Acid Cycle;Coenzyme A;cofactor;conditional knockout;CRISPR screen;CRISPR/Cas technology;Data;Dependence;Disease;Disorder of neurometabolic regulation;Drosophila genus;effector T cell;Electron Transport;Enzymes;Essential Genes;experimental study;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fibroblasts;fitness;gene synthesis;Genes;Glycolysis;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Immune;Immunity;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interferon Type II;intraepithelial;Iron;iron metabolism;Ketoglutarate Dehydrogenase Complex;Knock-out;Knockout Mice;Lamina Propria;lipid metabolism;Lipids;long chain fatty acid;loss of function mutation;Lymphocyte;Malignant Neoplasms;Mediating;mesenteric lymph node;Metabolic;Metabolic Pathway;Mitochondria;Mitochondrial Diseases;mitochondrial metabolism;Modeling;Modification;Nerve Degeneration;novel strategies;overexpression;Oxidative Phosphorylation;Oxidoreductase;Pathway interactions;Patients;Play;Process;Production;programs;Proliferating;Proteins;Pulmonary Inflammation;Regulatory T-Lymphocyte;Respiration;respiratory;Role;Skeletal Myoblasts;Spleen;Sulfur;T cell differentiation;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Thioctic Acid

PROJECT_TITLE: Evaluating the role of Mecr and Mitochondrial Fatty Acid Synthesis in T cell Function and Metabolism

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The midbody is a microtubule rich organelle packed with proteins and enriched for specific RNAs required for proper cell division. This proposal will uncover mechanisms that regulate how those RNAs are localized to the MB, shedding light on this vital regulator of mitosis. This study focuses on experimental and computational approaches to identifying regulatory elements driving mRNAs to the MB, and the completion of this work will lead to novel insights into mechanisms of mRNA localization to other subcellular locations.

PI_NAMEs: VAETH, KATHERINE F (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: 3' Untranslated Regions;Aneuploidy;Automobile Driving;Biological Assay;Cell Cycle Progression;Cell division;cell type;Characteristics;CRISPR/Cas technology;Cytokinesis;Data;daughter cell;Defect;Development;Elements;Event;Excision;experimental study;Gene Expression;Gene Expression Regulation;Genomic Instability;Goals;insight;Laboratories;Light;Location;Machine Learning;Mediating;Messenger RNA;Microtubules;Mitosis;Mitotic;Modality;Molecular;molecular imaging;Neurons;novel;Organelles;physical separation;Play;polarized cell;Post-Transcriptional Regulation;predictive modeling;Process;Proteins;recruit;Regulatory Element;Reporter;RNA;RNA Transport;RNA-Binding Proteins;single molecule;Site;Structure;Techniques;Testing;Tissues;trafficking;Trans-Activators;Transcript;Translations;Work

PROJECT_TITLE: High-throughput experimental and computational identification of RNA elements that regulate trafficking to midbodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Type I interferon is a signaling molecule, produced and secreted upon a cell’s detection of virus, that creates an antiviral state in nearby cells to prevent further infection. AMOTL2 is a gene with no previously described antiviral role that appears to contribute to the type I interferon response against Zika virus. A better understanding of the mechanism and breadth of AMOTL2’s antiviral phenotype will improve our basic understanding of the type I interferon response against viruses.

PI_NAMEs: WILLCOX, ALEXANDRA CLAIBORNE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: A549;Adult;Affect;Americas;Anti-viral Response;Asian;Binding;Biological Assay;cell immortalization;Cell Line;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR library;cytokine;Data;Defect;Development;Disease;Disease Outbreaks;Epithelial Cells;Exhibits;experimental study;Feedback;fighting;Flavivirus;future outbreak;Genes;Genetic Techniques;Genetic Transcription;Guillain Barré Syndrome;Heterogeneity;Human;IFI6 gene;IFNAR1 gene;Immune response;Immunologic Factors;improved;Infection;innate immune pathways;Innate Immune Response;Innate Immune System;Integration Host Factors;interferon antagonist;Interferon Receptor;Interferon Type I;Interferons;Knock-out;knockout gene;Learning;Lung;Mediating;Mediation;Microcephaly;Modeling;Molecular Genetics;mosquito-borne;Natural Immunity;Nervous System Disorder;Neurologic;Neurological outcome;Newborn Infant;novel;novel therapeutics;Outcome;pathogen;Pathway interactions;Persons;Phenotype;Play;prevent;programs;Proteins;receptor;Reproducibility;response;Role;Screening Result;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;System;Testing;therapy development;Up-Regulation;Viral;viral detection;Viral Genes;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work;Zika Virus;ZIKV disease;ZIKV infection

PROJECT_TITLE: Characterizing host proteins that restrict Zika virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE A large body of evidence from epidemiological studies suggests that a significant contribution of environmental toxicants, such as World Trade Center (WTC) airborne particulate matter (PM) and heat stress (HS) are associated with poor cognitive health and elevated risk of Alzheimer's Disease (AD). Our proposed studies will characterize age-dependent cascades in response to WTC airborne PM and climate changes and will advance our understanding of gene-environment interactions in the late-onset Alzheimer's Disease (LOAD) mouse model relevant to WTC first responders.

PI_NAMEs: PASINETTI, GIULIO MARIA (contact)

PROJECT_TITLE: WTC Airborne Particulate and Climate Change as Risk Factors of Late-Onset Alzheimer's  Disease


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: WORCESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: NARRATIVE To enable development of fast and accurate brain and human body modeling methods and their transition to clinical practice via a dedicated computational conference on Brain and Human Body Modeling aligned with NIMH mission.

PI_NAMEs: MAKAROFF, SERGEY N (contact)

PROGRAM_OFFICER_NAME: MEZA-CERVERA, TATIANA

PROJECT_TERMS: 3-Dimensional;Acoustics;Alzheimer's Disease;Brain;Brain Neoplasms;Cephalic;clinical practice;Clinical Research;Computer Models;computerized tools;Computing Methodologies;cost;Dedications;Deep Brain Stimulation;design;Development;Diagnostic;Discipline;Distant;Dose;Dystonia;Educational workshop;effective therapy;electric field;Electric Stimulation;electrical potential;Electrodes;Electroencephalography;Electromagnetics;Employment;Essential Tremor;experience;Focused Ultrasound;Future;Head;Human;Human body;Implanted Electrodes;improved;Industrialization;Investigation;Learning;Link;magnetic field;Magnetic Resonance Imaging;Magnetism;Magnetoencephalography;Measurement;Measures;Mental Depression;Mental disorders;Methods;Mission;Modality;Modeling;Modernization;Monitor;National Institute of Mental Health;neurophysiology;neuroregulation;Neurosciences;noninvasive brain stimulation;Parkinson Disease;Pathologic;Patients;Persons;Physiologic pulse;portability;research clinical testing;Resolution;Safety;Scalp structure;side effect;Signal Transduction;standard care;success;symposium;Techniques;Technology;Training;training opportunity;Transcranial magnetic stimulation;Ultrasonic wave;Underrepresented Populations;Vision;voltage;Woman

PROJECT_TITLE: Brain and Human Body Modeling Conference (BHBM) – from Fast and Accurate Computational Modeling to Clinical Practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (C1)]


PHR: PROJECT NARRATIVE We propose “Microbiome Targeted Treatment of WTC- Lung Injury” to address fundamental gaps in knowledge in the potential of utilizing bacteriotherapy in treatment of WTC-related exposure and lung disease. We examine the role of RAGE and IL-17-related inflammatory pathways in a longitudinal cohort of firefighters who participated in our FIREHOUSE trial, and further develop murine models to test the utility of bacteriotherapy to mitigate World Trade Center Lung Injury.

PI_NAMEs: KWON, SOPHIA S (contact)


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Kidney Disease;Microbiome;Prevention;Sepsis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Acute kidney injury in sepsis is common, costly, and responsible for high mortality and long-term morbidity. In preliminary studies of experimental sepsis and hospitalized patients, we have discovered that the gut microbiome plays an important but poorly understood role in sepsis-associated acute kidney injury. This project aims to understand how the gut microbiome contributes to the pathogenesis of kidney injury in sepsis, which will help provide insights that may lead to advances in its prevention and treatment.

PI_NAMEs: WINNER, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Animal Model;Antibiotic Therapy;Antibiotics;Archives;Bacteria;bacterial community;biobank;Biological;biological heterogeneity;Biological Markers;Body Weight decreased;clinical heterogeneity;clinical practice;Clinical Research;clinically significant;cohort;Cohort Studies;Communities;Complication;Computerized Medical Record;cost;Creatinine;Critical Illness;Data;data repository;Development;Endotoxins;Experimental Designs;Experimental Models;experimental study;Exposure to;Family;Functional disorder;Germ-Free;Gnotobiotic;Goals;gut bacteria;gut microbiome;gut microbiota;Health Care Costs;Heterogeneity;Histology;Hospitalization;Human;Immune response;improved;Infection;Injury;Injury to Kidney;innovation;Inpatients;insight;intraperitoneal;Kidney;Knowledge;Laboratories;Life;Logistic Regressions;Matched Case-Control Study;Measurement;Measures;Mediating;Mediator;Methods;Michigan;microbial;microbial community;microbiome;microbiome composition;microbiota;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;new therapeutic target;Odds Ratio;Organ;Outcome;Pathogenesis;Patient risk;Patient-Focused Outcomes;Patients;Persons;Play;Prevalence;Prevention;Preventive treatment;Rectum;repository;Research;Research Design;Resources;response;Retrospective cohort study;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA;Role;Scientist;Sepsis;septic patients;Series;Serum;Severities;Source;Sterility;Swab;Syndrome;Techniques;Temperature;Testing;therapeutic target;Training;translational approach;Universities;Variant;Work

PROJECT_TITLE: A translational approach to interrogate the gut microbiome in sepsis-associated acute kidney injury

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative In this proposal we will test the hypothesis that T cell receptor ligation in the epidermis augments “fitness” of resident memory T cells through cell-intrinsic epigenetic modification thereby allowing for augmented persistence and effector function. We will also determine if stromal cells determine to size of the epidermal memory T cell niche. Both hypotheses will also be examined in the context of chronic antigen stimulation.

PI_NAMEs: KAPLAN, DANIEL H (contact);SINGH, HARINDER

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Alopecia Areata;antigen-specific T cells;Antigens;Antineoplastic Agents;autocrine;Autoimmune Diseases;Candidate Disease Gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;Chromatin;Chromatin Structure;Chronic;Complex;cytokine;Data;Development;Disease;Doxycycline;draining lymph node;E-Cadherin;effector T cell;Engineering;Epidermis;Epigenetic Process;epigenetic profiling;epigenomics;Epithelial Cells;fitness;flexibility;Genes;Genetic Transcription;Grant;Herpes Simplex Infections;Host Defense;Immigrant;Immune response;Immunologic Surveillance;in vivo;Infection;Infectious Skin Diseases;Inflammation;integrin beta6;Integrins;keratinocyte;Ligation;lymph nodes;Maintenance;Mediating;Melanoma;Melanoma Tumor;Memory;Modeling;Modification;Monoclonal Antibodies;multiple omics;Mus;Pathogenicity;Peptides;Pharmaceutical Preparations;Phase;Phenotype;Population;Positioning Attribute;Psoriasis;Reaction;recruit;residence;response;Rest;Role;Shapes;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;Skin;skin disorder;Skin Tissue;small molecule;Spleen;Stromal Cells;T cell differentiation;T cell response;T memory cell;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic target;tissue resident memory T cell;Tissues;Transactivation;Transforming Growth Factor beta;Transplantation;tumor;Tumor Antigens;Vaccinia virus;Virus Diseases;Vitiligo;X-linked mental retardation 9

PROJECT_TITLE: Intrinsic and Extrinsic factors regulating competition for active TGFb promote skin memory CD8 T cell fitness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Pediatric;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Recreational cannabis legalization (RCL) is swiftly expanding in the United States, but virtually nothing is known about its long-term effects. Our original grant suggested that adults living in RCL states used cannabis 20% more frequently within approximately five years of legalization, even after controlling for pre-legalization risk factors. This renewal project would examine whether elevated use persists and is associated with the development of psychosocial and physical health consequences approximately ten years after legalization.

PI_NAMEs: ELLINGSON, JARROD MARTIN (contact);RHEE, SOO H;VRIEZE, SCOTT IAN;WILSON, SYLIA

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Accounting;Address;Adolescence;Adult;Adverse effects;Affect;Alcohol abuse;Alcohol consumption;alcohol use disorder;Behavior;Behavior assessment;Benefits and Risks;Cannabis;Chronic;cohort;Colorado;Cross-Sectional Studies;Data;design;Economics;emerging adulthood;Environment;Environmental Risk Factor;Epidemiology;Grant;Health;Individual;Individual Differences;Legal;Link;Literature;Long-Term Effects;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;marijuana legalization;marijuana use;Marketing;Mental Health;Minnesota;Modeling;Natural experiment;Nature;novel;Outcome;Pain;Participant;Personality;physical conditioning;Policies;Policy Maker;Population;prospective;psychosocial;psychosocial development;Public Health;public health relevance;Public Opinion;Recreation;Reporting;Research Design;Risk;Risk Factors;risk perception;Sampling;Sleep;substance use;Symptoms;Testing;Treatment/Psychosocial Effects;Twin Multiple Birth;United States;Variant;virtual;young adult

PROJECT_TITLE: The Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin Cohorts

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The Cancer Moonshot Blue Ribbon Panel Report laid out a roadmap for accelerating cancer research and clinical application of findings, one of the necessary components being the generation of tumor atlases. We propose to combine our expertise in clinical oncology, cancer biology, omics, imaging, and bioinformatics to establish a research center that will create a molecular1y resolved spatial PCa atlas. This atlas will provide a unique resource and unprecedented opportunities for research and clinical communities to better understand the key transitions in PCa progression and the biologic underpinnings of PCa disparities among African American patients.

PI_NAMEs: CHEN, FENG ;DING, LI  (contact);FIELDS, RYAN C;PACHYNSKI, RUSSELL K.

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;African American;African American population;African ancestry;American;analysis pipeline;androgen deprivation therapy;androgen independent prostate cancer;anti-cancer research;Architecture;Archives;ATAC-seq;Atlases;Binding;Bioinformatics;Biological;Biological Assay;Biological Markers;Biopsy;Cancer Biology;Cancer Center;cancer health disparity;cancer imaging;Cancer Patient;cancer therapy;Castrate sensitive prostate cancer;Castration;cell type;Cells;Clinical;clinical application;Clinical Data;clinical imaging;Clinical Oncology;Clonality;Collaborations;Communities;computerized tools;Coupled;Data;Data Analyses;Data Coordinating Center;data integration;Data Set;data standards;Death Rate;deep learning;Deposition;Detection;Diffusion;Dimensions;Disparity;diverse data;Ecosystem;effective therapy;Evolution;exome sequencing;experience;FAIR principles;Fluorescence Microscopy;Fostering;Foundations;Future;Generations;Genes;Genome;Genomics;Goals;health disparity;Human;Image;imaging modality;Immune;improved;In Vitro;in vivo;Incidence;indexing;Indolent;Infrastructure;Investigation;Light;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medicine;member;men;Metastatic Prostate Cancer;Methodology;Molecular;molecular dynamics;Molecular Profiling;mortality;multidimensional data;multiple omics;Mutate;Mutation;Neighborhoods;Neoplasm Metastasis;novel;Operative Surgical Procedures;Optics;overtreatment;Pathway interactions;patient population;Patients;Phase;Policies;Positron-Emission Tomography;Probability;Process;prospective;prostate cancer progression;Prostatectomy;Prostatic Neoplasms;proteogenomics;Proteomics;reconstruction;relational database;Reporting;repository;Research;Research Personnel;Resistance;Resolution;Resources;Sampling;screening;single cell sequencing;single nucleus RNA-sequencing;spatial relationship;spatiotemporal;Specimen;spectrograph;Technology;technology platform;therapeutic target;Three-Dimensional Imaging;Time;Tissues;tool;transcriptome sequencing;transcriptomics;tumor;tumor microenvironment;Universities;Validation;Washington;Work

PROJECT_TITLE: Human Prostate Tumor Atlas Center


ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The development of effective therapies for the treatment of autoimmune diseases requires a lucid understanding of the mechanisms by which T cell responses to self-antigens are effectively controlled. Here, will perform a clonal analysis of naturally occurring "Tr1" cells, which are characterized by production of the immunosuppressive cytokine IL-10 and exhibit potent regulatory activity capable of preventing or stifling T cell- driven autoimmune reactions. Ultimately, these insights will be crucial for the development of new strategies to mobilize Tr1 cells for the treatment of human autoimmune disease.

PI_NAMEs: SAVAGE, PETER AIDAN (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adopted;anergy;Antigens;Area;Autoantigens;Autoimmune;Autoimmune Diseases;Biology;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Chronic;Clinical Treatment;Clonal Deletion;commensal microbes;cytokine;Data;Development;directed differentiation;effective therapy;Exhibits;FOXP3 gene;Functional disorder;Gene Expression Profile;Homeostasis;Human;Immune system;Immunologics;In Vitro;in vivo;Inflammation;insight;interest;Interleukin-10;Knowledge;Laboratory mice;Mediating;mouse model;Mus;Nature;Pathogenicity;Pattern;Peripheral;Phenotype;Population;Prevalence;prevent;Production;Reaction;Recurrence;Regulation;Regulatory T-Lymphocyte;Research;Seminal;Specific qualifier value;Specificity;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymus Gland;Tissues;transcriptome sequencing;Transgenic Mice;Wild Type Mouse

PROJECT_TITLE: Clonal analysis of naturally occurring IL-10-producing Tr1 cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_CITY: LITTLE ROCK

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative This project focuses on links between circulating glucose metabolism and age-related processes occurring in the cells in the brain that support the neurons. These studies will test the idea that these support cells lose some of their ability to move glucose from the circulation to the neurons, which contributes to the cognitive problems associated with aging and further exaggerated in Alzheimer’s disease. Ultimately, it is anticipated that this study will help us understand changes that occur during aging that make the elderly more vulnerable to disorders such as Alzheimer’s disease, and perhaps even the mental deterioration that sometimes occurs in diabetes.

PI_NAMEs: BARGER, STEVEN W (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;age effect;age related;age related decline;Age-associated memory impairment;age-related disease;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;Astrocytes;Attenuated;behavior test;Biological Assay;Blood Circulation;blood glucose regulation;Blood Vessels;Brain;brain parenchyma;brain tissue;Cell membrane;cell type;Cells;Cerebral cortex;Cerebrum;Chickens;Chronic;Circulation;Cognition;Cognitive;Compensation;conditional knockout;Defect;Dependence;Desire for food;Deterioration;Diabetes Mellitus;Disease;egg;Elderly;Elements;Endothelium;Energy Metabolism;Exhibits;Gene Modified;Genetic;Glucose;glucose metabolism;glucose tolerance;Glucose tolerance test;glucose transport;Glucose Transporter;GLUT-3 protein;Hippocampus;Human;Hyperglycemia;hyperphosphorylated tau;impaired glucose tolerance;Impairment;innovation;Insulin;Insulin Resistance;Interruption;Link;Memory;Memory impairment;Memory Loss;metabolic rate;Modification;Mus;Nerve Degeneration;Nervous System Physiology;Neurologic;Neurons;neurophysiology;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;Obesity;overexpression;Overweight;Pancreas;Performance;Peripheral;Phenotype;Physical activity;Play;Process;Protein Isoforms;Proteins;Psyche structure;Resolution;Role;SLC2A1 gene;spatial memory;Specimen;Supporting Cell;Surveys;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;trafficking;trait;uptake;Work

PROJECT_TITLE: Compromised function of a glial glucose transporter in aging and Alzheimer's disease


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Pathway damage from the brain to the spinal cord and brainstem leads to motor impairments in the upper limbs of individuals experiencing a one-sided stroke. This may result in the use of indirect motor pathways and greater output of the transmitter norepinephrine. Elevated norepinephrine heighten motoneuron excitability and increases the use of indirect motor pathways, exacerbating impairments. In this study, we explore the impact of a drug-induced reduction in norepinephrine on motoneuron excitability, the diminished use of indirect motor pathways, and the consequent improvement in functional use of the affected arm.

PI_NAMEs: DEWALD, JULIUS P (contact);YAO, JUN

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Affect;Animal Experimentation;Area;arm;arm paresis;Attenuated;Brain;Brain Injuries;Brain Stem;Chronic;chronic stroke;Clinical;Corticospinal Tracts;Coupling;Data;density;Diameter;Elbow;Electroencephalography;empowerment;experience;Fingers;Goals;Grant;Hand;hemiparetic stroke;Human;Hyperactivity;Impairment;improved;Individual;Intervention;Isometric Exercise;Joints;Kinetics;Knowledge;Lesion;Lifting;Link;locus ceruleus structure;Measurement;Measures;Methods;Mission;Monitor;Motor;motor behavior;Motor Cortex;motor disorder;motor impairment;Motor Neurons;Motor Pathways;Movement;Muscle;Muscle Hypertonia;Muscle relaxation phase;Muscle Weakness;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Nervous System;neural;Neuromodulator;neuronal excitability;Norepinephrine;novel;Outcome;Output;Pathway interactions;Performance;Pharmaceutical Preparations;Pharmacology;Placebos;post stroke;Quality of life;Ramp;Rehabilitation therapy;Research;response;Robot;Robotics;Role;Science;Shoulder;Signal Transduction;spasticity;Spinal;Spinal Cord;stretch reflex;Stretching;Stroke;stroke survivor;Surface;Survivors;synergism;Testing;theories;tizanidine;Torque;United States;Upper Extremity;Work;Wrist

PROJECT_TITLE: Effect of Neural Constraints on Movement in Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Our previous research suggests the differential adverse effects and quantitative chest CT imaging characteristics of the longitudinal lung function trajectories of the WTC workers, and markers suggesting early chronic disabling lung disease. We thus propose to test the use of added respiratory surveillance tools and explore functional markers of disease progression, explore alternate methods to investigate longitudinal functional trajectories, and novel spirometry calibration methods that might facilitate the implementation of spirometry in nonspecialized settings.

PI_NAMEs: DE LA HOZ, RAFAEL E. (contact)

PROJECT_TITLE: Enhancing Surveillance Spirometry of At-Risk Occupationally Exposed Populations


PHR: PROJECT NARRATIVE Cardio-renal vascular dysfunction is a serious global public health challenge and may be associated with gastroesophageal reflux disease (GERD) and environmental toxins including world trade center-particulate matter (WTC-PM) have great impact on these two end organ diseases. This project will explore cardiovascular and renal vascular dysfunction/injury due to WTC exposure in WTC exposed first responders (Fire Department of the City of New York) and in murine WTC-PM exposure, specifically the role of macrophages and transforming growth factor-beta in the pathophysiology of renal dysfunction/fibrosis will be assessed. Successful completion of this project may identify biologically relevant biomarkers of WTC-PM-induced cardio-renal vascular injury.

PI_NAMEs: VEERAPPAN, ARUL  (contact)

PROJECT_TITLE: World Trade Center Particulate Matter-Associated End Organ Dysfunction: Targeting Early Vascular Dysfunction and Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The  collective  burden  of  various  neurodegenerative  diseases  is  large,  yet  no  active  therapeutics  exist  to  effectively  slow  disease  onset  or  progression.  The  studies  proposed  in  this  application  will  allow  us  to  determine  the  molecular  and  cellular  mechanisms  through  which  ataxin- 1  regulates  oligodendroglial  differentiation  and  function,  and  will  elucidate  the  non- neuronal  contributions  to  neurodegenerative  diseases,  revealing  novel  potential  entry  points  for  therapeutic  intervention  in  disorders  associated  with  ataxin- 1  mutations  such  as  spinocerebellar  ataxia  type  1,  frontotemporal  dementia,  amyotrophic  lateral  sclerosis,  and  Alzheimer’s disease.

PI_NAMEs: LIM, JANGHOO  (contact)

PROJECT_TERMS: Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyotrophic Lateral Sclerosis;ataxin-1;Autopsy;Behavioral;behavioral impairment;Biochemical;Biological Assay;CAG repeat;Cell Line;Cell Lineage;cell type;Cells;Central Nervous System;Cerebellar Ataxia;Cerebellum;Code;Codon Nucleotides;cohort;Complex;Data;Dependence;Disease;Disease Progression;DNA Sequence Alteration;Event;Exons;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Gene Expression;genetic approach;Goals;high standard;Histologic;Human;human induced pluripotent stem cells;human tissue;Impairment;In Vitro;in vivo;insight;Interruption;Investigation;Knock-in Mouse;Knockout Mice;Length;loss of function;Modeling;Molecular;mouse genetics;Multiple Sclerosis;Mus;mutant;Mutation;Myelin;myelination;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Onset of illness;Pathogenesis;Pathologic;Phenotype;polyglutamine;Population;Process;Progressive Nonfluent Aphasias;Proteins;Purkinje Cells;Research;Risk;Role;Sampling;selective expression;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;sporadic amyotrophic lateral sclerosis;stem cell differentiation;stem cells;Therapeutic;Therapeutic Intervention;Time;Tissues;transcription factor;Trinucleotide Repeat Expansion;Type 1 Spinocerebellar Ataxia

PROJECT_TITLE: Investigation of the role of ATXN1 in oligodendroglia and neurodegenerative diseases

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

PHR: PROJECT NARRATIVE Hepatitis C is a widely prevalent bloodborne viral infection that may lead to chronic liver disease and accounts for an estimated 1.1 million annual global deaths. Within the last six years, direct acting antivirals have demonstrated high cure rates across all genotypes in 8 to 12 weeks of all-oral treatment; however, the lack of nucleic acid amplification tests available to outpatient clinics has hampered the ability to link patients to available treatment and confirm their viral suppression after treatment. We propose to develop and validate a point-of- care, pan-genomic Hepatitis C nucleic acid test that can provide results in less than 30 minutes and be used by untrained users in a wide range of outpatient clinical settings.

PI_NAMEs: POSNER, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: 2019-nCoV;Accounting;Adult;Aftercare;Ambulatory Care Facilities;Anti-viral Agents;antibody test;Archives;Biological Assay;Blood capillaries;blood fractionation;Blood specimen;Buffers;Cessation of life;Chemistry;Chronic Hepatitis C;chronic infection;chronic liver disease;Clinic;Clinical;Complex;cost;Custom;Cytolysis;Decentralization;design;Detection;Development;Devices;Diagnosis;diagnostic platform;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;Eligibility Determination;Enterobacteria phage MS2;epidemic virus;Equipment;experience;Fluorescence;follow-up;Genomics;Genotype;global health;Goals;Heating;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Viremia;Hepatitis C virus;Infection;Influenza;innovation;internal control;isothermal amplification;Laboratories;Link;Liver;Mechanics;Mediating;Medical center;Methods;miniaturize;Modeling;novel;novel strategies;Nucleic Acid Amplification Tests;Nucleic Acids;Optical Readers;Oral;Outcome;Outpatients;Paper;Patient Care;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;point of care;point of care testing;Polymerase;Preparation;Primary carcinoma of the liver cells;Process;programs;Protocols documentation;Qualifying;rapid diagnosis;rapid test;Reaction;Reader;rechargeable battery;recombinase;Reference Standards;Resources;Respiratory Disease;Reverse Transcription;Ribonucleases;RNA;RNA purification;RNA Viruses;Robotics;Running;Sampling;Solid;Technology;Test Result;Testing;therapeutically effective;Training;Translating;Translations;United States National Institutes of Health;Validation;validation studies;Venipunctures;Venous;Viral;viral detection;Viral hepatitis;viral RNA;Viremia;Virus Diseases;virus testing;Whole Blood;Work

PROJECT_TITLE: Point-of-care Nucleic Acid Amplification Test for pangenomic Hepatitis C diagnosis in outpatient clinics

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: An estimated 20,000 deaths each year are attributable to skin cancer. There is a major need to better understand the molecular evolution of skin neoplasia, and to address this need, we propose development of a pre-cancer atlas of skin cancer. Completion of these studies will reveal diagnostic and prognostic markers of progression and open new avenues of therapeutic intervention.

PI_NAMEs: BASTIAN, BORIS C.;SHAIN, ALAN HUNTER (contact);YEH, IWEI

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Acral Lentiginous Malignant Melanoma;Address;Adopted;Alleles;Antigens;Area;Atlases;B-Cell Antigen Receptor;B-Lymphocytes;Biological;Biological Assay;Biological Markers;Biotechnology;cancer care;Cancerous;cell type;Cells;Cessation of life;Charge;Classification;Clinical;clinical practice;Communities;Computer software;Custom;Darkness;Data;Data Analyses;Data Coordinating Center;Data Set;data sharing;Databases;Dedications;design;Development;Diagnosis;diagnostic accuracy;diagnostic algorithm;diagnostic biomarker;Disease;DNA sequencing;driver mutation;Environment;Epithelial Cells;Epithelium;Event;Evolution;exome;Funding;Gene Expression Profile;Generations;Genetic;genomic data;Genomics;Genotype;Goals;Growth;Human Resources;Immune;immune cell infiltrate;Immune system;Immunologic Surveillance;Immunologics;immunosuppressed;Immunotherapy;improved;Individual;insight;Institution;Interest Group;keratinocyte;Knowledge;laboratory experience;Lesion;Life;Malignant Neoplasms;malignant phenotype;Maps;melanocyte;Melanocytic Neoplasm;Melanoma;Messenger RNA;Modeling;Molecular;Molecular Evolution;Monitor;Mutation;neoantigens;Neoplasms;neoplastic;new therapeutic target;Organ;outreach;Patients;Persons;Phase;Pigments;predictive marker;premalignant;Process;Production;prognostic algorithm;Prognostic Marker;progression marker;Proteins;Proteomics;Research;Resolution;Resources;restraint;Role;Sampling;senescence;Series;Shapes;Skin;Skin Cancer;skin squamous cell carcinoma;Somatic Mutation;success;Surveys;T-Lymphocyte;Technology;Therapeutic;Therapeutic Intervention;Tissues;transcriptome sequencing;transcriptomics;Translations;tumor;tumorigenesis;United States;user-friendly;Work;World Health Organization

PROJECT_TITLE: Pre-cancer atlas of skin cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M3)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

PHR: Project Narrative There are strong correlations between the bacterial communities that grow in the digestive system (the gut microbiome) and immune responses in the lungs in settings of chronic diseases. However, we understand very little about how this gut-lung axis regulates responses to acute bacterial infections in the lungs. My studies will reveal how the gut microbiome promotes respiratory host defense lung-derived signals that stimulate homeostatic Th17 immunity.

PI_NAMEs: ORLOV, MARIKA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;acute infection;Address;Affect;Amoxicillin;Animal Model;Animals;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;Asthma;Autoimmune Diseases;bacterial community;Bacterial Infections;Bacterial Pneumonia;Calibration;Cell Count;Cells;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Colitis;Colorado;Cystic Fibrosis;Data;Diet;Digestive System Disorders;Distant;Environment;Epithelium;experience;gastrointestinal system;Goals;gut bacteria;gut microbiome;gut-lung axis;Helper-Inducer T-Lymphocyte;HIV;Host Defense;Human;IL17 gene;Immune;Immune response;Immunity;Immunology;Infection;Inflammation;Inflammatory Response;Interleukin-6;Intervention;Intestines;Investigation;Knockout Mice;Leukocytes;Life;Link;Literature;Long-Term Effects;Lung;Lymphocyte;Lymphocyte Biology;lymphocyte trafficking;Measures;Mediating;Mediator;Medical;Mentors;microbial homeostasis;microbiome;microbiome alteration;microbiome analysis;Molecular;mortality;Muc 2 protein;Mucins;Mucous body substance;Mucous Membrane;Mus;Natural Immunity;novel;Organ;pathogen;Persons;Phenotype;Pneumonia;Population;Positioning Attribute;Predisposition;Protein Isoforms;Regulation;Reporter;Research;respiratory;Respiratory Tract Infections;response;Rheumatism;Severities;Severity of illness;Signal Transduction;Staphylococcus aureus;Sterility;Structure of parenchyma of lung;Surface;Techniques;Testing;Tissues;Training;Universities;Wild Type Mouse

PROJECT_TITLE: Epithelial Contributions to Lung Immunity


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PHR: PROJECT NARRATIVE: Dysregulated cell-cell adhesion is a feature of many disease states, but how adhesive structures are dynamically regulated is less well understood. This project investigates how a central scaffolding component integrates chemical and mechanical signals to control the form and function of epithelial barriers.

PI_NAMEs: QUINN, JEANNE MARIE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Address;Adherens Junction;Adhesions;Adhesives;Adopted;afadin;alpha catenin;Apical;Binding;Binding Sites;Biochemical;Butterflies;Cadherins;Canis familiaris;career development;causal variant;Cell Line;Cell-Cell Adhesion;Cells;Cellular biology;Charge;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Couples;Cytoskeleton;Data;Development;Developmental Delay Disorders;Disease;Epithelial Attachment;Epithelial Cells;Epithelium;Excision;Eye;Eye diseases;F-Actin;F-actin-binding proteins;flexibility;fly;Forms Controls;Functional disorder;Future;Goals;Homeostasis;Hydrocephalus;Immunofluorescence Immunologic;In Vitro;in vivo;inhibitor;interest;Intervention;Intrinsic drive;kidney epithelial cell;Knock-out;knockout gene;Knockout Mice;Link;loss of function;Maintenance;Maps;mechanical signal;Mechanics;Membrane;Mentorship;Methods;microscopic imaging;Missense Mutation;Modeling;Modification;Molecular;Molecular Conformation;Morphogenesis;mouse model;Mus;mutant;Mutation;novel;Ophthalmology;organ growth;Pathway interactions;Pattern;Permeability;Phenocopy;Phenotype;Phospho-Specific Antibodies;Phosphorylation;Physicians;Post-Translational Protein Processing;postnatal;Proteins;quantitative imaging;recruit;Regulation;reinforcer;Research;scaffold;Scaffolding Protein;Scanning;Scheme;Scientist;Shapes;Signal Transduction;Site;skills;Structure;Testing;Tissues;Training;X-Ray Computed Tomography;Zonula Adherens

PROJECT_TITLE: Alpha-catenin phosphorylation is mechanosensitive and required for epithelial barrier structure-function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Mass drug administration (MDA) of azithromycin (AZ) for children under 5 has the potential to reduce infections and mortality. In recent years, MDA AZ is being widely implemented across sub-Saharan Africa; yet there is little evidence on how its benefit in reducing child morbidity and mortality may be affected by the routine administration of seasonal malaria chemoprevention (SMC) and by contextual and socioeconomic factors that may affect access to treatment. This study will use rigorous intervention research and epidemiologic methods to examine if the effect of mass AZ is modified by SMC, and distance from health facilities and community wealth (as it relates to access to treatment/antibiotic) and provide new evidence on whether administering MDA AZ with SMC, and for communities with less access to healthcare is more effective in improving outcomes.

PI_NAMEs: GEBREEGZIABHER, ELISABETH A (contact)

PROGRAM_OFFICER_NAME: MOYE, JACK

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;aged;Amodiaquine;Antibiotics;Antiparasitic Agents;Azithromycin;Biometry;Burkina Faso;care seeking;career;Censuses;Cessation of life;Chemoprevention;Child;Child Health;Child Mortality;Chloroquine;Clinic Visits;Clinical Treatment;Cluster randomized trial;Communicable Diseases;Communities;Competence;Data;Diagnosis;Diarrhea;Disease;disease transmission;Distant;Dysentery;Effectiveness;Epidemiologic Methods;Exposure to;Fever;Future;gastrointestinal infection;Goals;Health;health care availability;Health care facility;health care service utilization;Health Services Accessibility;Heterogeneity;Household;improved;improved outcome;Individual;Infection;Infectious Disease Epidemiology;insight;Intervention;Intervention Studies;Knowledge;Low Birth Weight Infant;Macrolides;Malaria;malaria infection;malaria transmission;Meningitis;Mentorship;Methodology;Methods;Mission;Morbidity - disease rate;mortality;multiple data sources;National Institute of Child Health and Human Development;Neighborhoods;Niger;Outcome;Pharmaceutical Preparations;placebo group;Placebos;Pneumonia;poor communities;Poverty;Pregnant Women;Premature Birth;Preschool Child;prevent;Primary Health Care;Principal Component Analysis;Productivity;programs;Pyrimethamine;Randomized;randomized trial;Research;Research Methodology;Research Personnel;residence;Resistance;Resources;Respiratory Tract Infections;Risk;scale up;Seasons;skills;social epidemiology;Socioeconomic Factors;Statistical Methods;Sulfadoxine;surveillance data;Training;Upper Respiratory Infections

PROJECT_TITLE: Heterogeneity of the effect of Azithromycin on morbidity and mortality among children in Burkina Faso

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Mutations in our genome often give cancer cells a fitness advantage to divide and survive uncontrollably, but, by virtue of their unique appearance in cancers, can also stimulate an anti-cancer immune response. The goal of this project is to dissect how the most common mutation in Epidermal Growth Factor Receptor, designated L858R, stimulates an anti-tumor immune response through activating T cells, key players of the immune system. Knowledge gained from this project will inform the development of wide-reaching, off-the-shelf immunotherapies for cancer patients.

PI_NAMEs: WANG, STEPHEN LEE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Accounting;adaptive immunity;Affect;anti-cancer;anti-tumor immune response;Antigen Presentation;antigen-specific T cells;Antigens;Antitumor Response;Appearance;Binding;Biological Assay;Blocking Antibodies;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;cell mediated immune response;Cells;Cellular Immunity;Characteristics;clinically relevant;Clonality;Complex;Coupled;cytotoxicity;Data;Development;driver mutation;Engraftment;Epidermal Growth Factor Receptor;exhaustion;exome sequencing;fitness;Flow Cytometry;Gene Fusion;Genetic;Genome;Germ Lines;Goals;Growth;HLA Antigens;Immune;immune checkpoint blockade;Immune response;Immune system;immunogenic;immunogenicity;Immunoprecipitation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;individual patient;insertion/deletion mutation;Interferon Type II;Knowledge;KRAS2 gene;liquid chromatography mass spectrometry;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;Mus;mutant;Mutation;neoantigens;Non-Small-Cell Lung Carcinoma;Oncogenes;Patients;Peptide Receptor;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Privatization;Process;Productivity;Proto-Oncogenes;Receptor Cell;Scientist;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Sorting;Specificity;Stains;T cell receptor repertoire sequencing;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Tissues;Titrations;tool;Training;tumor;Tumor Biology;tumor growth;Tumor Immunity;Work

PROJECT_TITLE: Defining features of the neoantigen-specific T cell response against a common EGFR mutation in lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


PHR: Project Narrative As the World Trade Center general responder cohort ages, the implementation of healthy aging interventions that target health priorities of WTC general responders becomes increasingly important. The goals of this study are to: (1) examine the implementation of an intervention to improve medication use in WTC general responders; and (2) identify health priorities of aging WTC general responders that can inform future efforts to support healthy aging in this population. This work will enable the timely development and implementation of interventions to promote healthy aging that take into account the unique structure of the WTC clinical center of excellence programs as well as the characteristics and needs of the WTC general responder population.

PI_NAMEs: HUNG, WILLIAM W.,MPH, MD (contact);KO, FRED CHAU-YANG

PROGRAM_OFFICER_NAME: YIIN, JAMES

PROJECT_TITLE: Promoting healthy aging and improving medication use in World Trade Center general responders

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 LEE (52)]


PHR: PROJECT NARRATIVE This project assesses how messaging about the tobacco product continuum of risk impacts adults who use combustible tobacco products (including those who have not yet been able to quit) and youth/young adults (those who have never used tobacco products and those who use non-combustible products). We will assess each audience's immediate response and receptivity to such messaging, psychophysiological effects highly predictive of behavior change, and immediate and longer-term (6-month) tobacco use behaviors using a series of six interconnected studies. This work has an adaptive and nimble design that will provide FDA with comprehensive, rigorous and organized evidence regarding message effects and effective message features for future public health communications.

PI_NAMEs: MORAN, MEGHAN BRIDGID (contact);TAN, ANDY SL

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Address;Adult;Age;Area;Attention;Behavior;behavior change;behavior prediction;Behavioral;behavioral economics;Biochemical;Cognitive;cognitive interview;Cohort Studies;Collaborations;combustible tobacco;Communication;Complement;Comprehension;Cross-Sectional Studies;Data;Depth Perception;design;Discipline;Ecological momentary assessment;Effectiveness;experimental study;Exposure to;Future;Goals;handheld mobile device;Harm Reduction;Health;health communication;health equity;insight;Laboratories;Life Cycle Stages;Long-Term Effects;Methodology;Nature;neuroimaging;Nicotine;Nicotine Dependence;Outcome;Patient Self-Report;Perception;Persuasive Communication;Population;prevent;Psychiatry;Psychophysiology;Public Health;Random Allocation;Randomized;Randomized, Controlled Trials;Relative Risks;Research;Research Design;Research Personnel;response;Risk;Sampling;Science;Series;Site;Smoker;Smoking;sound;Specific qualifier value;Subgroup;Surveys;Testing;theories;Theory of Change;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;visual tracking;Work;young adult;Youth

PROJECT_TITLE: From Perceptions to Behaviors: A Comprehensive Approach to Examine the Impact of Public Health Communication Messaging about the Continuum of Risk for Tobacco Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Although cannabis use for both therapeutic and recreational treatment of mental health concerns is increasing, especially among emerging adults, a research gap assessing the cognitive and psychobiological mechanisms underlying cannabis use behaviors following a traumatic event remains. Two important cognitive processes involved in cannabis use decision-making are inhibitory control and reward motivation. The proposed project utilizes a multi-modal approach (i.e., psychophysiology, behavioral tasks, ecological momentary assessment, computational modeling) to identify and isolate idiographic profiles of these decisional processes and develop longitudinal models of posttraumatic stress and cannabis use behavior in emerging adults.

PI_NAMEs: KARNICK, ALEKSANDR T (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Accident and Emergency department;Acute;Affect;Age;Anhedonia;Arousal;Attitude;Behavioral;Behavioral Model;behavioral response;biobehavior;Biosensor;Cannabis;cannabis use behavior;career;Choice Behavior;Clinical;Cognitive;cognitive process;Computer Models;Data;Decision Making;Development;Ecological momentary assessment;emerging adult;emerging adulthood;Emotional;Esthesia;Etiology;Event-Related Potentials;executive function;experience;Exposure to;follow-up;Frequencies;Future;Galvanic Skin Response;Goals;Heart Rate;hedonic;Impairment;Impulsivity;in vivo;Individual Differences;innovation;insight;Intervention;Knowledge;longitudinal analysis;Manuscripts;marijuana use;marijuana use disorder;marijuana user;Measurement;Measures;Mental Health;Methodology;Modeling;Motivation;multimodality;National Research Service Awards;novel;Organism;Outcome;Parameter Estimation;parent project;Parents;Participant;Patient Self-Report;Pattern;Physiological;Population;post-trauma;post-traumatic stress;Post-Traumatic Stress Disorders;post-traumatic symptoms;Predisposition;Preparation;prevent;Prevention;Procedures;Process;programs;Psychiatry;psychobiologic;Psychological Factors;Psychophysiology;Psychotherapy;Recommendation;Recreation;recruit;Reporting;Research;response;reward processing;Rewards;Sampling;skills;social culture;sociocultural determinant;Stimulus;stress reactivity;Symptoms;Therapeutic;Therapeutic Uses;Training;Training Programs;Trauma;trauma exposure;trauma symptom;traumatic event;traumatic stress;trend;wearable sensor technology;young adult

PROJECT_TITLE: Cannabis use, trauma, and self-regulatory cognitive processes: A multimodal study integrating biobehavioral markers and ecological assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: Early life sleep lays the foundation for the neural circuitry that facilitates affiliative behavior. This work will investigate how early life sleep disruption impacts the developmental trajectory of inhibition in brain regions involved in the display of affiliative behavior in the highly social prairie vole (Microtus ochrogaster). Finally, we directly probe a mechanism by testing whether an enriched sensory environment rescues impairments in circuit development and affiliative behavior induced by early life sleep disruption.

PI_NAMEs: MILMAN, NOAH EMERY POLLAK (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acceleration;adequate sleep;Adolescence;Adolescent;Adult;affiliative behavior;Animals;Appearance;autism spectrum disorder;autistic children;Behavior;Behavioral;behavioral impairment;Benchmarking;Brain;brain cell;Brain region;brain tissue;Cell Count;cell type;Cells;Clinical;comparison control;Complex;computerized tools;critical period;Cues;Data;Development;Disease;Environment;environmental enrichment for laboratory animals;Equilibrium;excitatory neuron;experience;Extracellular Matrix;Extracellular Structure;Familiarity;Female;Foundations;Goals;Home;Housing;Impairment;inhibitory neuron;insight;Interneurons;Laboratory mice;Laboratory Rat;Life;male;Manuals;Maps;Mediating;Microtus;Modeling;Molecular;Mus;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel;Pair Bond;Partner in relationship;Parvalbumins;Pathogenesis;Phenotype;postnatal;prairie vole;pre-clinical research;preference;Proxy;Randomized;Rattus;REM Sleep;Rodent;Role;Same-sex;Sensory;sensory cortex;sex;Shapes;Siblings;Side;Sleep;Sleep Deprivation;Sleep disturbances;sleep regulation;social;Social Behavior;Social Development;social engagement;Social Interaction;Somatosensory Cortex;Stains;Structure;Testing;Therapeutic;Time;timeline;Touch sensation;Weaning;Work

PROJECT_TITLE: Role of early-life sleep and sensory environment in shaping the development of affiliative behavior and PV-interneurons in the somatosensory cortex of the highly social prairie vole.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Somatic hypermutation and affinity maturation are critical parts of the development of highly specific antibodies in natural immune responses in addition to biomedical technology for development of new therapeutics. Agnathans (i.e., jawless vertebrates) and gnathostomes (i.e., jawed vertebrates) have functionally convergent but structurally divergent antibodies utilized and antigen receptors (antibodies) for the recognition of pathogens. The proposed research is relevant to public health because it will further our understanding of the flexibility and limitations of SHM-mediated diversification and affinity maturation of structurally very different but functionally very similar antigen receptors.

PI_NAMEs: CHEN, JESSICA WT (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: activation-induced cytidine deaminase;Adaptive Immune System;Affinity;Amino Acids;Antibodies;Antibody Diversity;antigen binding;Antigen Receptors;Antigens;Aptitude;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biomedical Technology;Biophysics;Biotechnology;Cell Lineage;Chickens;cost;Data;design;Development;Evolution;Exons;experimental study;Fc Receptor;flexibility;Genes;Genetic Variation;Goals;Homologous Gene;Immune response;Immunoglobulin Somatic Hypermutation;immunoglobulin structure;Immunoglobulins;Immunologic Receptors;in silico;In Vitro;in vivo;insight;Jaw;Lampreys;Leucine-Rich Repeat;Libraries;Life;Lymphocyte;lymphoid structures;Mammals;Mediating;Methods;Modeling;mouse model;Mus;Mutation;novel therapeutics;Outcome;pathogen;Pathogenicity;Play;Process;Property;protein expression;Proteins;Public Health;receptor;Research;Role;Specificity;Structure;Structure of germinal center of lymph node;technology development;Testing;Time;Translating;V(D)J Recombination;Variant;Vertebrates

PROJECT_TITLE: Structural and functional integrity of antigen receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE PancreasFest 2024 will benefit patients who deal with pancreatitis, pancreatic cancer, and other pancreatic disorders by providing a forum for leading experts in the field of pancreatology to present updates, discuss results of current research and inform clinical practice. No other conference focuses on these disorders from a translational research and clinical implications perspective. The meeting format encourages all attendees to participate in discussion related to providing the best possible clinical care.

PI_NAMEs: ABU-EL-HAIJA, MAISAM  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Academic Medical Centers;acute pancreatitis;Address;Advisory Committees;Area;Basic Science;bench to bedside;Biological Markers;career development;Caring;chronic pancreatitis;Clinical;clinical care;clinical center;clinical practice;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communities;Dedications;Digestive System Disorders;Discipline;Disease;Education;Elements;Epidemiologist;experimental study;Faculty;Fostering;Foundations;Goals;Guidelines;Human;Industry;innovation;interest;International;Junior Physician;Learning;Malignant neoplasm of pancreas;Medical;meetings;Methods;Mission;Molecular;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Ohio;Operative Surgical Procedures;Pancreas;Pancreatic Diseases;Pancreatitis;Pathologist;Patients;pediatrician;Physicians;programs;radiologist;Research;Research Personnel;Research Priority;Science;Scientist;Suggestion;Surgeon;Surgical Management;symposium;System;targeted treatment;Time;translational approach;Translational Research;Universities;Update;Work;working group

PROJECT_TITLE: PancreasFest 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (M3)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Degeneration of the stria vascularis within the inner ear leads to a major type of age-related hearing loss affecting hearing sensitivity and speech perception for many older adults. The proposed research will investigate how age-related changes in mitochondrial function within the stria vascularis impacts the inflammaging phenotype identified by cochlear macrophages. The results may highlight mitochondrial dysfunction as a key target aimed to ameliorate or slow the progression of chronic inflammation known to be associated with age-related hearing loss.

PI_NAMEs: JENKINS, TYREEK RAYSHAWN (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Affect;Age;age effect;age related;age related changes;Age related pathologies;age-related disease;aged;Aging;Area;Atrophic;Auditory;Auditory Brainstem Responses;Auditory Threshold;Automobile Driving;Bioenergetics;CBA/CaJ Mouse;cell age;Cells;cellular transduction;Chronic;Cochlea;combat;Communication;Cytoplasm;Data;density;design;Disease;Endolymph;Epithelium;experimental study;Functional disorder;Genetic;Hair Cells;Hearing;hearing impairment;Homeostasis;Human;Image;Immune;immune activation;Immunohistochemistry;Impairment;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Ions;Laboratories;Labyrinth;Lateral;Length;Liquid substance;Literature;LoxP-flanked allele;Macrophage;Macrophage Activation;Measures;Membrane Potentials;Metabolic;middle age;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Molecular Profiling;mouse model;Mus;Nature;Neurons;older adult;Outer Mitochondrial Membrane;Oxidative Stress;Pathologic;Pathology;Pattern;Permeability;Phenotype;potassium ion;Presbycusis;preservation;prevent;promoter;Quality Control;Quality of life;Reactive Oxygen Species;Research;Respiration;respiratory;Role;Sensory Hair;Signal Transduction;Site;Speech Perception;Stress;Stria Vascularis;superresolution microscopy;System;Testing;therapeutic development;therapeutic target;transcriptome;Vascularization;young adult

PROJECT_TITLE: Mitochondrial dysfunction as a promoter of stria vascularis degeneration and inflammation in metabolic presbyacusis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The axon initial segment is the site of action potential generation and requires high densities of voltage-gated ion channels to carry out this function. In contrast to other axon initial segment ion channels, it is unknown how Kv1 potassium channels are targeted to this subcellular domain. The goal of this project is to elucidate the molecular mechanisms by which Kv1 channels localize at the axon initial segment.

PI_NAMEs: PALFINI, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Action Potentials;Ankyrins;Antibodies;Axon;Binding;Biological Assay;Brain;career;Cell Culture Techniques;Cells;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Communication;Complex;conditional knockout;CRISPR/Cas technology;Critical Thinking;Cytoskeleton;Data;density;Development;Disease;Epitopes;experience;Experimental Designs;experimental study;Future;Generations;Genes;Goals;Health;In Vitro;in vivo;Injections;Ion Channel;Ion Channel Gating;knock-down;Knock-out;Knockout Mice;Link;Membrane Proteins;Mentorship;Modeling;Molecular;mouse model;Nature;Nervous System;Nervous System Physiology;neuronal excitability;Neurons;novel;Peripheral Nervous System;Play;Potassium;Potassium Channel;Production;protein complex;Proteins;Reagent;recruit;Research;Research Personnel;Research Project Grants;Role;Scaffolding Protein;SCN1A protein;Shapes;Site;skills;Sodium;Spectrin;Stains;Surface;Synapses;tool;Training;Transfection;voltage;Western Blotting;Work

PROJECT_TITLE: Molecular mechanisms of Kv1 channel localization at the axon initial segment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Over half of World Trade Center (WTC) exposed Fire Department of New York (FDNY) rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett’s Esophagus (BE) and subsequent esophageal cancer. There is diminished health-related quality of life and productivity associated with aerodigestive diseases such as GERD and BE. Our research will continue to leverage the longitudinally phenotyped WTC exposed cohort, identify/validate novel biomarkers of WTC-aerodigestive disease, develop novel, noninvasive disease phenotyping to promote early diagnosis of premalignant disease, and identify potential targeted therapeutics; goals that are in line with the James Zadroga 9/11 Health & Compensation Act.

PI_NAMEs: NOLAN, ANNA  (contact)

PROJECT_TITLE: Aerodigestive Disease in the World Trade Center Exposed FDNY Cohort: Validation of Biomarkers and Defining Risk to Tailor Therapy


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Asthma is one of the most common physical health conditions in World Trade Center (WTC) responders, affecting approximately one third of individuals and it is a major source of morbidity and poor quality of life. In this study we will enhance and adapt an evidence-based asthma self-management support model for WTC responders with asthma and conduct a pilot randomized controlled trial to determine feasibility and preliminary impact, in preparation for a fully powered trial.

PI_NAMEs: FEDERMAN, ALEX D;WISNIVESKY, JUAN P (contact)

PROJECT_TITLE: Comprehensive Self-Management Support for WTC Responders with Asthma


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE As a social determinant of health, language barriers put patients who speak a language other than English (LOE) at increased risk for worse health outcomes in critical care. Yet, there is a significant gap in the science regarding prevention of ICU delirium for LOE patients. The proposed study will address this gap by exploring facilitators and barriers to ICU delirium prevention care for LOE patients in the ICU by interviewing key stakeholders in ICU delirium prevention care. Findings from this study will contribute to developing interventions in ICU delirium prevention for linguistically diverse patients that will improve health equity for this population of underserved patients.

PI_NAMEs: AHRENS, EMILY  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Agitation;Area;Breathing;care delivery;care outcomes;career;Caring;Clinical Practice Guideline;Code;Communication;Communication Board;Communication Tools;Critical Care;critical care nursing;Critical Illness;Data;Delirium;design;Disparity;doctoral student;English Language;Equity;Evidence based intervention;Exclusion;experience;Family;Family member;Fellowship;Future;Goals;Health Care Costs;health disparity;health equity;health inequalities;Health Personnel;high risk;Hispanic;Hospital Costs;Immobilization;implementation fidelity;implementation framework;implementation measures;implementation science;implementation strategy;implementation study;improved;improved outcome;Incidence;Individual;Individual National Research Service Award;Inequity;Influentials;innovative technologies;Intensive Care Units;Intervention;Interview;Knowledge;Language;language outcome;Latino;Length of Stay;lens;Linguistics;Literature;Measures;Mechanical ventilation;Medical;Medical center;Medicine;member;Mentors;Methodology;Methods;Modeling;mortality risk;multimodality;National Institute of Nursing Research;Nurses;Nursing Research;Pain;Participant;Patient Admission;patient-clinician communication;Patients;Persons;poor health outcome;pre-doctoral;Prevalence;prevent;Prevention;Prevention strategy;programs;Questionnaires;Reduce health disparities;Research;Research Personnel;Research Training;responsible research conduct;Risk;Risk Reduction;School Nursing;Science;Scientist;Sedation procedure;skills;Sleep;social health determinants;Societies;Strategic Planning;Structure;Survivors;System;systematic review;Testing;Time;tool;Training;Underserved Population;Universities;usability;Vulnerable Populations;Washington;Work

PROJECT_TITLE: Examination of Health Disparities in ICU Delirium Prevention and Management for Patients Who Speak A Language Other Than English

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (05)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Narrative: This study will contribute to the mechanistic understanding of how HPV upregulation of MARCHF8 remodels the tissue/tumor microenvironment to promote HNSCC. Further, uncovering mechanisms of HPV immune evasion may help identify novel targets for immunotherapies that enhance current treatments for HPV+ HNSCC patients.

PI_NAMEs: VU, LEXI  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: anti-tumor immune response;Antigen Presentation;Antitumor Response;Autophagocytosis;Autophagosome;carcinogenesis;CD8-Positive T-Lymphocytes;cell killing;Cells;Cessation of life;checkpoint therapy;chemotherapy;chronic infection;Complex;Confocal Microscopy;CRISPR screen;Data;Degradation Pathway;Development;Disease Progression;Down-Regulation;Epidemic;exhaust;exhaustion;experience;FDA approved;Genes;Genetic;genome-wide;Head and Neck Squamous Cell Carcinoma;high risk;Histocompatibility Antigens Class I;HPV negative;HPV positive;HPV-negative head and neck cancer;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunologic Receptors;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;Impairment;Incidence;inhibition of autophagy;inhibitor;innovation;Knock-out;Link;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Membrane;membrane model;Modeling;Mus;neoplastic cell;novel;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;Papillomavirus;Pathway interactions;patient response;Patients;pharmacologic;pre-clinical;Process;Proteins;Radiation;receptor;recruit;risk variant;standard care;Surface;T-Lymphocyte;Testing;Tissue Model;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Up-Regulation

PROJECT_TITLE: Membrane Ubiquitin Ligase-Driven Immune Evasion in HPV+ Head and Neck Cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Lung diseases represent an enormous worldwide health burden and most share old age as their primary risk factor, yet age is rarely studied as a variable in the lab. Age negatively impacts the repair function of alveolar type 2 cells, the crucial cells that protect the gas exchange surface, but it is unclear why. This project will improve our understanding of the contribution of immune signals in the aging lung to the repair dysfunction of alveolar type 2 cells; knowledge crucial to understanding the causation of lung disease and developing more effective medical care in older adults.

PI_NAMEs: JENSEN, JAKE  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;adaptive immunity;Age;age related;age-related disease;aged;Aging;Alveolar;alveolar epithelium;Apoptotic;ATAC-seq;Biological Assay;Bleomycin;Blocking Antibodies;Blood capillaries;Caring;Cause of Death;cell growth;Cell Proliferation;cell regeneration;cell type;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Coculture Techniques;Complex;Confocal Microscopy;COVID-19/ARDS;cytokine;Cytoprotection;Data;Data Set;Disease;disease model;Distal;Effector Cell;Elderly;Epithelial Cells;Epithelium;Etiology;exhaustion;Exhibits;Exposure to;Flow Cytometry;Functional disorder;Future;Gases;Gene Expression Profile;Genes;Health;healthy aging;Homeostasis;Human;human old age (65+);Imaging Techniques;Immune;Immune response;Immune signaling;Impairment;improved;In Situ Hybridization;in vivo;Incidence;Individual;Infiltration;Inflammation Mediators;Influenza;Injury;injury and repair;Interferon Type II;Interstitial Lung Diseases;Knowledge;Life;Lung;Lung Diseases;lung injury;lung repair;Lymphocyte;Lymphocyte Depletion;Lymphocyte Subset;Mammalian Cell;Measures;Mediator;Medical;Modeling;Mus;Natural Immunity;Natural Killer Cells;Natural regeneration;neutralizing antibody;Nuclear RNA;old mice;older adult;Older Population;Organoids;overexpression;Paracrine Communication;Play;Population;Preventive care;Proteins;regeneration function;regenerative;Regenerative capacity;regenerative cell;repair function;repaired;Reporting;Repression;Risk Factors;RNA;Role;scaffold;self-renewal;Severity of illness;Signal Transduction;Site;Source;Stains;stem cell exhaustion;stem cell function;stem cell population;stem cells;Structure of parenchyma of lung;Surface;surfactant;Surveys;targeted treatment;Testing;Tissues;Transcription Coactivator;transcriptome sequencing;Work

PROJECT_TITLE: Mechanisms of regenerative decline in aged alveolar type 2 cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Psychosis;Serious Mental Illness;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Understanding the social and environmental determinants of mental health is a key objective for current clinical psychological research given the impact that such factors have on the emergence and maintenance of costly mental health disorders such as psychosis spectrum disorders. The proposed study will utilize an innovative multimethod approach combining census tract neighborhood databases, virtual neighborhood audits, ecological momentary assessment, geographical information science methodology, and virtual neighborhood visits by naïve raters to illuminate how neighborhood environmental factors contribute to momentary experiences of paranoid ideation and to examine whether these environments play an independent role in increasing paranoid ideation. Gaining understanding of how localized contextual factors contribute to momentary paranoid ideation is vital to accurately assessing psychosis spectrum symptomatology in the community and individually adapting community-based mental health treatments to maximize both short and long-term benefits.

PI_NAMEs: ORTH, RYAN  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adult;Area;Behavioral;Belief;Black race;career;Cellular Phone;Censuses;Characteristics;Clinical;clinically significant;Communities;contextual factors;cost;Crime;Data;Data Collection;Data Reporting;Databases;Delusions;deprivation;Diagnostic;disability;Disease;Ecological momentary assessment;Environment;Environmental Risk Factor;experience;Exposure to;Feeling;Foundations;Funding;Geography;Green space;ideation;Individual;individual response;Information Sciences;innovation;Intervention;Life;Literature;Maintenance;Measures;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Movement;National Institute of Mental Health;negative affect;Neighborhoods;novel strategies;Outcome;Participant;Patient Self-Report;Perception;Play;Prognosis;programs;psychologic;Psychopathology;Psychoses;public database;Publications;Quality of life;Recommendation;Reporting;Research;Research Personnel;research study;response;Risk Factors;Role;Sampling;Schizophrenia;Secondary to;skills;social;social deficits;social determinants;spatial epidemiology;Statistical Methods;symptomatology;Symptoms;Techniques;Time;tool;Training;United States National Institutes of Health;virtual;virtual visit;Visit

PROJECT_TITLE: Using Geocoded Data and Virtual Neighborhood Assessments to Understand the Impact of Neighborhood Environment on Momentary Paranoid Ideation in Psychosis