ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE This study responds to Notice of Special Interest (NOSI): Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (NOT-MD-21-014 ) and the need to increase HIV testing and PEP/PrEP use among African-American or Black gay, bisexual, same gender-loving or other MSM (henceforth Black MSM). In response, we propose a study to test the effectiveness of a multilevel and multicomponent HIV prevention intervention that combines evidence-based, individual-, interpersonal- (peer) and community-level components, built around a CBO-delivered PEP/PrEP navigation program in Central Brooklyn (a geographic hotspot in NYC), to increase primary outcomes of past 3-month HIV testing and PEP/PrEP uptake over 18 months. The findings from this study will have important implications for HIV prevention uptake in key populations and as they can be integrated into existing dissemination efforts.

PI_NAMEs: BOND, KEOSHA TARHESHIA;FRYE, VICTORIA  (contact);KELVIN, ELIZABETH A;KOFFLER, ELISE ADELE;ZHANG, HONGBIN

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acceleration;Adherence;Affect;African American;aged;AIDS prevention;Anxiety;Area;barrier to testing;Behavior;Bisexual;black men who have sex with men;Black Populations;Black race;Cognitive;Collaborations;Communities;community consultation;community organizations;coping;Cox Proportional Hazards Models;design;Discrimination;Dissemination and Implementation;effectiveness testing;Eligibility Determination;Empirical Research;empowerment;Enrollment;Epidemic;evidence base;experience;Exposure to;Feedback;Feeling;Focus Groups;four-arm study;Fright;Fumarates;Gays;Gender;Geography;high risk;HIV;HIV Infections;HIV/AIDS;Homophobia;Human immunodeficiency virus test;Immunoassay;implementation framework;Individual;interest;internalized stigma;Interruption;Intervention;intervention mapping;Interview;Lateral;Length;Love;Manuals;Measures;Media Campaign;Medical;Medical Records;men;men who have sex with men;Methods;metropolitan;Modeling;Motivation;multi-component intervention;Navigation System;Newly Diagnosed;novel;Outcome;Patient Self-Report;Persons;Pharmaceutical Preparations;point of care testing;Population;pre-exposure prophylaxis;Prevention;preventive intervention;primary outcome;Printed Media;Printing;program dissemination;programs;Quasi-experiment;racism;Randomized;Recommendation;recruit;Research;Resistance;response;secondary outcome;Self Care;Self Efficacy;self testing;Series;service providers;Services;side effect;skills;social;social media;social stigma;Social support;standard of care;Tenofovir;Testing;Time;Training;United States;uptake;urban area;urban dwelling;Urine;usability;Visual

PROJECT_TITLE: Estimating the Impact of a Multilevel, Multicomponent Intervention to Increase Uptake of HIV Testing and Biomedical HIV Prevention among African-American/Black Gay, Bisexual and Same-gender Loving Men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CHENEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: EASTERN WASHINGTON UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Defects of the inosine triphosphate pyrophosphohydrolase (ITPA) protein can complicate treatment of certain life-threatening conditions, and severe defects can result in a deadly infantile encephalopathy, DEE 35. We aim to discover a molecule that can bind to ITPA variants and reverse these defects using computational and biochemical methods to screen a virtual and physical library of 300,000 drug-like molecules. By identifying a molecule that can interact with ITPA to restore proper ITPA function, we aim to provide the groundwork for the development of a drug that can reduce negative outcomes for patients with ITPA defects.

PI_NAMEs: BURGIS, NICHOLAS EARL (contact);HOUNDONOUGBO, YAO ATHANASE

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Adopted;Affect;Affinity;alpha helix;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Catalysis;Cell Physiology;Clinical;clinically relevant;Collaborations;Complex;Computer Models;Computer Simulation;Data;Defect;design;Development;Disease;Docking;drug discovery;drug-like compound;Effectiveness;Encephalopathies;enzyme activity;Enzyme Kinetics;Enzymes;epileptic encephalopathies;experience;experimental study;flexibility;Funding;Goals;Health;High Pressure Liquid Chromatography;high throughput screening;Human;in silico;Individual;infancy;innovation;Inosine;inosine triphosphatase;insight;Kinetics;Lead;Libraries;Life;Ligand Binding;Ligands;Lobe;Malignant Neoplasms;Methods;Molecular;molecular dynamics;mutant;Mutation;Nucleic Acids;nucleoside triphosphate;Outcome;Patient-Focused Outcomes;Patients;personalized approach;Pharmaceutical Preparations;Pharmacologic Substance;protein folding;Proteins;Publications;Rare Diseases;Reaction;Research;Research Personnel;Resource Sharing;Ribavirin;Role;screening;simulation;small molecule;small molecule libraries;Testing;thiopurine;tool;TRANCE protein;tripolyphosphate;undergraduate student;United States National Institutes of Health;Universities;Variant;virtual;virtual screening;Washington;Work

PROJECT_TITLE: Computational and biochemical screening for the discovery of molecules that stabilize ITPA clinical variants

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases

PROJECT_TERMS: Basic Science;Family Dasypodidae;Leprosy;Production;Reagent;Research;Research Support

PROJECT_TITLE: Leprosy Research Support in Armadillos


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORTH LIBERTY

ORG_NAME: JMI LABORATORIES

ORG_STATE: IA

PI_NAMEs: HUBAND, MICHAEL  (contact)

PROJECT_TERMS: Advanced Development;Anti-Bacterial Agents;Antibiotic Resistance;Bacteria;Bacterial Antibiotic Resistance;Biological Assay;combat;Contracts;Development;In Vitro;in vitro testing;Maintenance;pathogenic bacteria;screening;therapeutic development;Toxin

PROJECT_TITLE: Task A24: In Vitro Screening for Antibacterial Activity Against Bacterial Pathogens


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: JACKSON, REBECCA  (contact)

PROJECT_TERMS: Aging;Ancillary Study;Cardiovascular Diseases;Cardiovascular system;Classification;cohort;Data;Discipline;epidemiology study;Event;follow-up;Funding;Goals;innovation;Knowledge;Life;Modification;National Heart, Lung, and Blood Institute;older women;Participant;platform-independent;power analysis;Prevention trial;Qualifying;Quality of life;Research;Research Personnel;resilience;Resources;sample collection;Women's Health

PROJECT_TITLE: THE PURPOSE OF THIS MODIFICATION IS TO DE-OBLIGATE NHLBI FUNDING AND OBLIGATE NCI FUNDING.


PROJECT_TERMS: Aging;Ancillary Study;Cardiovascular Diseases;Cardiovascular system;Classification;cohort;Contracts;Data;Discipline;epidemiology study;Event;follow-up;Funding;Goals;innovation;Knowledge;Life;older women;Participant;platform-independent;power analysis;Prevention trial;Qualifying;Quality of life;Research;Research Personnel;resilience;Resources;sample collection;Women's Health

PROJECT_TITLE: WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Physical Activity;Pregnancy;Sleep Research;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: Biochemical Markers;Biological Specimen Banks;Birth;Blood;Body Weight;Cardiovascular Diseases;cohort;Denmark;Development;Diabetes Mellitus;Diet;Exercise;Genetic;Gestational Diabetes;Life Style;lifestyle factors;Maternal Health;Medical;Non-Insulin-Dependent Diabetes Mellitus;Nurses' Health Study;Participant;Pregnancy Complications;Pregnancy Histories;repository;Risk;Saliva;Services;Sleep;Specimen;Structure of nail of toe;Urine;Woman;Women's Health

PROJECT_TITLE: REPOSITORY SERVICES FOR DIABETES AND WOMEN'S HEALTH STUDY (DWH) SPECIMENS


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: ALS is a fatal neuromuscular disease. Most patients die within 5 years of disease onset. Veterans are twice as likely to be diagnosed with ALS as the general population. Despite intensive research efforts, there is no effective cure for ALS. Therefore, there is a dire need to develop novel and effective approaches to combat ALS. We will investigate the novel mechanism of intestinal dysfunction and dysbiosis in ALS and explore therapeutic targets for ALS by restoring healthy microbiome and intestinal homeostasis. Fulfillment of the studies will bring novel concepts to the ALS research and have significant translational implications for developing new therapeutic strategies for ALS in VA population and improving veterans' care. The proposed studies are, therefore, relevant to the VA patients as well as the general patient population.

PI_NAMEs: SUN, JUN  (contact)

PROJECT_TERMS: Address;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Autonomic nervous system;Bacteria;Bacteroidetes;Biochemical;Biological;Brain;Butyrates;Caring;Central Nervous System;Central Nervous System Diseases;Cessation of life;clinically relevant;combat;Communication;Complex;design;Diagnosis;Disease;Disease Progression;dysbiosis;Engineering;Enteric Nervous System;Environment;Epithelial Attachment;Evaluation;Experimental Animal Model;Experimental Models;FDA approved;fecal transplantation;feeding;Firmicutes;Functional disorder;Future;gastrointestinal;General Population;Goals;gut health;gut inflammation;gut microbiome;Health;Histopathology;host-microbe interactions;Human;Immune system;improved;innovation;intestinal barrier;intestinal homeostasis;Intestinal permeability;Intestines;Leaky Gut;life span;Link;microbial homeostasis;microbiome;Military Personnel;military veteran;Modeling;Molecular;motor neuron function;Motor Neurons;mouse model;Mus;Muscular Atrophy;Nervous System Disorder;neuromuscular;Neuromuscular Diseases;neuromuscular function;Neurons;neuroprotection;Neurosecretory Systems;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Onset of illness;oral microbiome;overexpression;Parkinson Disease;Pathogenesis;patient population;Patients;peace;Performance;Pharmaceutical Preparations;Physiological;Play;Population;preservation;Prevention;Probiotics;Production;protein TDP-43;Protocols documentation;Publications;Quality of life;Research;Riluzole;Risk;Risk Assessment;Role;Services;Spinal Cord;stem cells;Structure;System;Therapeutic;Therapeutic Effect;therapeutic target;Time;tool;Transgenic Animals;Veterans;War;Wild Type Mouse

PROJECT_TITLE: Microbiome and intestinal barrier in ALS therapy


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Childhood Injury;Congenital Structural Anomalies;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Brachial plexus birth injury, the most common nerve injury in children, is a traumatic injury occurring at birth that causes muscle paralysis, abnormal growth of the shoulder bones, and lifelong impairment of arm function. Almost nothing is known about the timing and drivers of changes to bone from altered passive mechanical loading from short muscles, reduced functional loading, and direct nerve injury effects following brachial plexus injury occurring at birth. The proposed work will significantly advance understanding of how deformity develops and persists, and ultimately enable more effective and consistent treatments – addressing both muscle and bone – for brachial plexus birth injury and other perinatal neuromuscular injuries.

PI_NAMEs: COLE, JACQUELINE H;SAUL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Activities of Daily Living;Address;Affect;arm;arm function;Articular Range of Motion;Automobile Driving;Biological;biomechanical engineering;Birth;Birth trauma;bone;Bone Development;bone geometry;Bone Growth;Bone structure;Brachial plexus structure;Categories;Child;Childhood Injury;Clinical;clinical decision-making;Complex;Computer Models;Computer Simulation;Consensus;Contracts;Contracture;critical period;Deformity;Denervation;Deposition;Development;Diameter;Engineering;Environment;Family;FGF2 gene;Forearm;Foundations;Future;Growth;Growth and Development function;Growth Factor;humerus;Impairment;improved;Individual;Injury;innovation;Insulin-Like Growth Factor I;joint loading;Joints;Knowledge;Limb structure;Location;loss of function;mechanical load;Mechanics;Metabolism;Minerals;Modeling;multidisciplinary;Muscle;Muscle Development;muscular structure;Musculoskeletal;Natural regeneration;nerve damage;nerve injury;neural;Neuromechanics;neuromuscular;Operative Surgical Procedures;Orthopedic Surgery;Osteogenesis;Osteotomy;Outcome;Paralysed;Perinatal;postnatal;postnatal period;Posture;preference;Public Health;Quality of life;Radial;rapid growth;Rattus;reduced muscle mass;Reporting;Research;Research Design;Rodent Model;Role;scapula;Shoulder;Signal Transduction;skeletal;Stimulus;Structure;Surgical Disarticulation;timeline;Tissues;Traumatic injury;Weight-Bearing state;Work

PROJECT_TITLE: Development and Persistence of Tissue-Level Musculoskeletal Deformity Following Brachial Plexus Birth Injury

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project narrative There is strong interest in utilizing oxytocin as a therapeutic for psychiatric disorders, yet the neural circuits underlying oxytocin action are poorly defined. The proposed experiments use rodent models to examine oxytocin neural circuits that mediate social anxiety and social approach.

PI_NAMEs: TRAINOR, BRIAN C (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Affect;Agonist;Animals;antagonist;Antisense Oligonucleotides;Anxiety Disorders;authority;Behavior;Behavioral;behavioral study;Bioinformatics;Brain region;California;Cells;Characteristics;Coupling;Data;Data Set;Development;Dose;Electrophysiology (science);experimental study;Female;GTP-Binding Proteins;Human;Hypothalamic structure;Impairment;Individual;Infusion procedures;innovation;insight;interest;male;Mediating;men;Mental disorders;mesolimbic system;Modeling;Molecular;Molecular Analysis;molecular phenotype;multidisciplinary;Mus;neural circuit;Neurons;Neuropeptides;novel;novel therapeutic intervention;Nucleus Accumbens;Oxytocin;Oxytocin Receptor;paraventricular nucleus;Participant;Pathway interactions;Performance;Pharmacology Study;Phenotype;Physiological;Population;Potassium Channel;receptor coupling;reduce symptoms;Reporting;Research;response;Rodent Model;Schools;sex;Sex Differences;Signal Pathway;Signal Transduction Pathway;single cell analysis;single-cell RNA sequencing;skills;social;social anxiety;Social Anxiety Disorder;Social Behavior;Social Controls;social defeat;Social Environment;Social Interaction;Social Phobia;social relationships;social stress;Stress;Structure of terminal stria nuclei of preoptic region;System;Testing;Therapeutic;therapeutic target;tool;Transcript;United States;vigilance;Viral;Viral Vector;Virus;Visualization;Woman;women versus men;Women's prevalence;Work

PROJECT_TITLE: Oxytocin-dependent circuits of social approach and vigilance

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN MATEO

ORG_NAME: REVAGENIX, INC.

PI_NAMEs: CIRZ, RYAN  (contact)

PROJECT_TERMS: Acinetobacter;Advanced Development;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;Pseudomonas aeruginosa;research and development;Research Support;safety assessment;Staphylococcus aureus;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Antibiotic Resistant Bacteria


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: HIV/AIDS;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: FERNANDO, RESHAN  (contact)

PROJECT_TERMS: abacavir;Adverse effects;Biological;cardiovascular health;Cardiovascular system;Chemicals;Chemistry;Contracts;cost;Data;Development;disorder prevention;Dose;dose information;Environmental Exposure;Evaluation;Exposure to;Formulation;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;Individual;Isomerism;Lamivudine;Metabolism;National Toxicology Program;Outcome;Preparation;Process;programs;public health research;Raloxifene;Reporting;Research;Risk Assessment;Risk Factors;Sampling;Series;Services;Sodium;sodium arsenite;sound;Specific qualifier value;Sulfate;Testing;Thallium;Toluene;Toxic effect;Toxicity Tests;Toxicology

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (General Chemistry Support and Contract Administration)


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Natural Products;Prevention

PROJECT_TERMS: Adverse effects;analytical method;Biological;Botanical dietary supplements;Cardiovascular system;Chemicals;Chemistry;Contracts;Development;disorder prevention;Dose;dose information;Environmental Exposure;Environmental Pollutants;Evaluation;Exposure to;Gas Chromatography;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;Individual;Mass Spectrum Analysis;Measures;Methods;Monitor;Monoterpenes;National Toxicology Program;Outcome;Pilot Projects;Population;Process;programs;Property;public health research;Reporting;Research;Resolution;Risk Assessment;Risk Factors;Sampling;Services;sound;Specific qualifier value;Testing;Therapeutic;Toxic effect;Toxicity Tests;Toxicology;Work

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (Chemistry Support for Cardiovascular Toxicology Studies)


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Adverse effects;Alcohols;aqueous;Biological;Chemicals;Chemistry;Contractor;Contracts;Development;disorder prevention;Dose;dose information;Environment;Environmental Exposure;Environmental Pollutants;Evaluation;Exposure to;Film;Fire - disasters;Formulation;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;improved;Individual;Liver;Military Personnel;National Toxicology Program;Outcome;Oxides;perfluorohexane;Plasma;Process;programs;public health research;Reporting;Research;Risk Assessment;Risk Factors;Rodent;Sampling;Services;sound;Specific qualifier value;Sulfonamides;Sulfonic Acids;surface coating;Surface Tension;Testing;Toxic effect;Toxicity Tests;Toxicology;Urine;Water

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (Poly- and perfluorinated substances , PFAS)


NIH_SPENDING_CATS: Natural Products;Prevention

PROJECT_TERMS: Adverse effects;Animals;Chemicals;Chemistry;Contracts;Development;disorder prevention;Dose;Environmental Exposure;Evaluation;Exposure to;Formulation;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;Individual;Materials Testing;Methods;Modeling;Monoterpenes;National Toxicology Program;Oral;Outcome;Process;programs;public health research;Reporting;Research;Risk Assessment;Risk Factors;Rodent;Sampling;Services;sound;Specific qualifier value;Testing;Tissues;Toxic effect;Toxicity Tests;Toxicokinetics;Toxicology

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (Monoterpenes)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions. Upon successful completion of the proposed research, we expect our contribution to be development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Our findings may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes.

PI_NAMEs: DAVIS, KATHRYN ADAMIAK (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Anatomy;Biological Markers;Biomedical Engineering;Brain;Brain region;Clinical;clinical care;Clinical Data;Collaborations;computational neuroscience;connectome;Coupling;Data;Development;Devices;Diagnostic tests;Diffusion Magnetic Resonance Imaging;Disease;Electrodes;Electroencephalography;Epilepsy;Evaluation;Functional Magnetic Resonance Imaging;Goals;Graph;Image;imaging biomarker;Imaging Device;Implant;implantation;improved;individual patient;innovation;Intervention;Intractable Epilepsy;Lasers;Lesion;Limbic System;Magnetic Resonance Imaging;Maps;Measures;Medical;Medicine;Methods;Morbidity - disease rate;multimodal data;Multimodal Imaging;Network-based;neuroimaging;neuroimaging marker;Neurology;neurosurgery;non-invasive imaging;novel;novel therapeutics;open source;Operative Surgical Procedures;Outcome;Partial Epilepsies;Patients;Pattern;Pennsylvania;personalized strategies;Persons;Pharmaceutical Preparations;predictive modeling;Procedures;professional atmosphere;Property;Public Health;Research;Resistance;Rest;Risk Reduction;Sampling;Sampling Errors;Seizures;South Carolina;spatiotemporal;Stereotyping;Structure;surgery outcome;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Translating;United States;Universities;Work

PROJECT_TITLE: Optimized Intracranial EEG Targeting in Focal Epilepsy based upon Neuroimaging Connectomics

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PI_NAMEs: WIEBEN, ERIC D (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Agreement;Area;bead chip;bioinformatics resource;Bioinformatics Shared Resource;Biological Sciences;bisulfite sequencing;Charge;Clinic;community center;Comprehensive Cancer Center;Consultations;Contracts;cost effective;Data;Dedications;deep sequencing;Development;DNA;Education;Ensure;Equipment;Event;exome;Funding;Gene Chips;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene function;Gene Structure;Genes;genome analysis;Genomics;Genotype;Goals;Grant;Human Resources;Institution;instrument;instrumentation;knock-down;Libraries;Mayo Clinic Cancer Center;member;Methylation;next generation sequencing;Nucleic acid sequencing;Peer Review;Price;Procedures;Process;Production;programs;Protocols documentation;Provider;Publications;Reagent;Research Personnel;Resource Sharing;Resources;RNA;RNA Interference;Sampling;Services;single molecule real time sequencing;Site;Specialist;Structure;System;Technical Expertise;Technology;technology development;technology platform;Time;timeline;Training;Transcript;Validation;whole genome

PROJECT_TITLE: Genome Analysis Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KOCHER, JEAN-PIERRE A (contact)

PROJECT_TERMS: analytical method;Area;Arizona;Attention;biobank;Bioinformatics;Bioinformatics Shared Resource;Biological;Biostatistics Shared Resource;Breast;Breeding;Cancer Center Support Grant;Categories;Clinic;Clinical Research;Code;Collaborations;commercial application;Communities;Comprehensive Cancer Center;computer cluster;Data;data access;data exchange;data management;Data Set;Data Sources;design;Development;Ensure;experience;Faculty;Florida;Funding;genome analysis;genomic data;Genomics;Genotype-Tissue Expression Project;Grant;Hematologic Neoplasms;Human Resources;improved;Infrastructure;Institution;Investments;Lead;Licensing;Lymphoma;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Methods;Mission;Multiple Myeloma;novel;open source;operation;Ovarian;Pancreas;Pathway Analysis;Pathway interactions;Positioning Attribute;Process;programs;Publications;Publishing;Quality Control;Research;Research Personnel;Resource Sharing;Resources;Review Literature;secondary analysis;Services;Site;Techniques;The Cancer Genome Atlas;tool;Update;Variant;Visualization;web portal;Woman;Work

PROJECT_TITLE: Bioinformatics Shared Resource


NIH_SPENDING_CATS: Cancer

PI_NAMEs: DUECK, AMYLOU CONSTANCE (contact)

PROJECT_TERMS: anti-cancer research;Area;Arizona;Authorship;Basic Science;bench to bedside;Biostatistics Shared Resource;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;Caregivers;Charge;Clinical;clinical trial protocol;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Comprehensive Cancer Center;Data;Data Analyses;Data Collection;data management;data quality;Data Set;database design;Development;Disease;Doctor of Philosophy;education research;Ensure;epidemiology study;Faculty;Family;Fostering;Funding;Future;Genetic;genetic epidemiology;Genomics;Grant;Health;high dimensionality;Human Resources;Institution;instrument;Intervention;Leadership;Malignant Neoplasms;Manuscripts;Mayo Clinic Cancer Center;Measurement;meetings;member;Methods;Modeling;Molecular Epidemiology;Monitor;multidimensional data;NCI Center for Cancer Research;Observational Study;Outcome;Patient Education;Patient Outcomes Assessments;Peer Review;Pilot Projects;Population;Population Sciences;precision medicine clinical trials;Preparation;Procedures;Productivity;programs;Protocols documentation;psychosocial;public education;Publications;Quality Control;Quality of life;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;Review Committee;Sample Size;Services;Site;Statistical Data Interpretation;success;Surrogate Endpoint;Techniques;Testing;tool;Translational Research;United States National Institutes of Health;Wages;Work;Writing

PROJECT_TITLE: Biostatistics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: KAUFMANN, SCOTT H (contact)

PROJECT_TERMS: Address;Adjuvant;Affect;Alleles;anti-cancer treatment;Antineoplastic Agents;Apoptotic;Area;Aromatase Inhibitors;Basic Science;BCL2 gene;Binding;Biochemical;Bioinformatics;Biological;Biometry;BRCA1 gene;BRCA2 gene;Breast Cancer Cell;breast cancer metastasis;cancer cell;career;CDK4 gene;Cell Proliferation;Cell Survival;Cells;Chemopreventive Agent;chemotherapy;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Combination immunotherapy;Comprehensive Cancer Center;Disease;DNA Damage;DNA Repair;DNA Repair Pathway;Doctor of Philosophy;Drug Kinetics;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;effective therapy;epithelial to mesenchymal transition;ERBB2 gene;Erinaceidae;Estrogen Receptors;Evaluable Disease;Family member;first-in-human;Floxuridine;Funding;Future;gemcitabine;Genetic;genome analysis;genome wide association study;Genomics;Goals;Grant;Hematopoietic;Hormonal;Immunologics;Immunooncology;improved;In Situ;Individual Differences;inhibitor;insight;Investigation;Investigational Therapies;Joints;Journals;Lung Adenocarcinoma;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Mentorship;Metabolic;Microscopy;mimetics;mitochondrial creatine kinase;Mutation;neoplastic;neoplastic cell;new therapeutic target;NOTCH3 gene;novel;novel anticancer drug;Oncogenic;Organ;Ovarian;Pathology;Pathway interactions;Patients;Peer Review;Pharmacogenetics;pharmacologic;Pharmacology;Pharmacy facility;phase 2 testing;phase I trial;phase II trial;Phosphotransferases;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Preclinical Drug Development;programs;Proliferating;Property;Protein Kinase;Proteomics;Proteomics Shared Resource;Publications;Publishing;Reagent;Research;research clinical testing;Research Personnel;Resistance;Resource Sharing;Resources;response;Running;Safety;safety assessment;Sampling;Selective Estrogen Receptor Modulators;Signal Pathway;Signal Transduction;Signal Transduction Inhibitor;Single Nucleotide Polymorphism;Site;small molecule therapeutics;Source;Tamoxifen;targeted treatment;Testing;Toxic effect;Translational Research;Translations;Tumor Suppressor Proteins;ubiquitin isopeptidase;Validation;Variant;Women's trial;Work

PROJECT_TITLE: Experimental Therapeutics Program


PI_NAMEs: KNUTSON, KEITH L. (contact)

PROJECT_TERMS: Alleles;Antibodies;Antibody Therapy;antigen-specific T cells;Antigens;Arizona;Basic Science;Behavior;Cancer Family;cancer immunobiology;cancer immunotherapy;cancer prevention;cancer recurrence;cancer therapy;Cancer Vaccines;Clinic;Clinical;clinical application;Clinical Trials;Collaborations;college;combat;Communities;Comprehensive Cancer Center;Dedications;Development;Direct Costs;Doctor of Philosophy;early phase clinical trial;Endowment;Ensure;Environment;experience;Extramural Activities;Family;Florida;Fostering;Funding;Future;Genes;Genetic Determinism;Goals;Grant;Grant Review;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;immune system function;Immunity;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Inflammation;innovation;insight;Journals;Knowledge;Malignant neoplasm of ovary;Malignant Neoplasms;Mayo Clinic Cancer Center;Medicine;Melanoma;member;Minnesota;Molecular;mortality;next generation;novel;novel therapeutics;Paper;particle;Patients;PD-1/PD-L1;Peer Review;Peer Review Grants;Peptides;prevent;Productivity;professor;programs;Publications;Publishing;Recruitment Activity;Regulation;Research Personnel;response;Science;Series;Site;standard of care;T-Lymphocyte;Teacher Professional Development;Testing;Therapeutic;Translational Research;Translations;treatment strategy;tumor immunology;vaccine development;vaccine trial;Viral Cancer;Virus;Woman;Work

PROJECT_TITLE: Cancer Immunology and Immunotherapy Program


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Microbiome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: BEKAII-SAAB, TANIOS  (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Area;Award;base;Basic Science;Cancer Center Support Grant;cancer diagnosis;Cancer Research Project;Catchment Area;Cessation of life;Clinic;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;design;Development;Diagnosis;Disease;Early Diagnosis;effective therapy;Evaluation;Faculty;Funding;Germ-Free;Goals;Grant;gut microbiome;healthcare burden;Hepatobiliary;improved;Incidence;individualized medicine;Infrastructure;innovation;insight;Institution;Investigation;Journals;Knowledge;Literature;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Mentors;Mentorship;metabolomics;microbiome;Mission;multidisciplinary;Mus;new therapeutic target;novel;novel marker;novel strategies;Outcome;Outcomes Research;Pathogenesis;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;predictive marker;Prevention;Prognostic Marker;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;Site;Stratification;Talents;Testing;therapy outcome;Translational Research;tumor microbiome;tumor microenvironment;United States National Institutes of Health;Work

PROJECT_TITLE: Gastrointestinal Cancer Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: ANSELL, STEPHEN M (contact)

PROJECT_TERMS: Achievement;Area;Arizona;Basic Science;biobank;Biometry;Bortezomib;Cancer Survivorship;Caring;Catchment Area;Categories;Cellular biology;Chronic Lymphocytic Leukemia;Clinic;Clinical;clinical care;clinical database;Clinical Drug Development;Clinical Investigator;Clinical Trials;Collaborations;Comprehensive Cancer Center;Disease;Drug Approval;Drug Targeting;Education;Enrollment;Ensure;Epidemiology;Florida;Foundations;Funding;Genes;Genetic;genetic epidemiology;genetic risk assessment;genome wide association study;Genomics;Goals;Grant;Hematologic Neoplasms;Hodgkin Disease;Immunologics;Individual;Institution;Investigation;Investigational Therapies;Laboratories;Large-Cell Lymphomas;Leadership;leukemia/lymphoma;Link;Literature;Lymphoma;Malignant Neoplasms;Mayo Clinic Cancer Center;meetings;member;Mentors;Molecular Biology;Multiple Myeloma;Myeloproliferative disease;National Cancer Institute;new therapeutic target;Nivolumab;novel;novel therapeutics;Output;Patient Care;Patients;Peer Review;Pharmacy facility;Population;Productivity;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Sampling;Science;Scientist;Signal Transduction;Societies;survivorship;Susceptibility Gene;Testing;Therapeutic Clinical Trial;tool;Translating;Translational Research;Virus

PROJECT_TITLE: Hematologic Malignancies Program


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

PI_NAMEs: SARKARIA, JANN N. (contact)

PROJECT_TERMS: Adult;Adverse effects;Area;Arizona;base;biobank;Bioinformatics;Biological Markers;Biometry;Brain;Brain Neoplasms;Burn injury;Cancer Center;Cancer Center Support Grant;cancer initiation;Cell Culture Techniques;Childhood;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;Comprehensive Cancer Center;Consent;Country;Cranial Irradiation;Dedications;Development;Disease;Environment;Epidemiology;experience;Faculty;Florida;Funding;Genetic Transduction;genomic locus;Genomics;Glioma;Gliomagenesis;Goals;Grant;Growth;Image;imaging biomarker;improved;Institution;Intensity modulated proton therapy;Intervention;Investigation;Journals;Laboratories;Leadership;Malignant neoplasm of brain;Manuscripts;mathematical model;Mayo Clinic Cancer Center;Medical Oncology;member;Minnesota;Molecular Biology;neuro-oncology;neuropathology;Neurosciences;Neurosurgeon;neurosurgery;Neurosurgical Procedures;novel therapeutic intervention;novel therapeutics;Oncologist;Oncology;Operative Surgical Procedures;Pain;Pathogenicity;Pathology;patient derived xenograft model;patient population;patient registry;Patients;Peer Review;personalized therapeutic;Pharmacology;physical science;Physicians;Population;Positioning Attribute;Positron-Emission Tomography;predictive marker;Primary Brain Neoplasms;Productivity;Prognosis;Program Development;programs;Proteomics;Proton Radiation;Publications;Publishing;Quality of life;Quality of Life Assessment;Quinones;R24;Radiation Oncologist;Radiation Oncology;Radiation therapy;recruit;reduce symptoms;Research;research and development;Resource Sharing;Resources;response;response biomarker;Scanning;Scientist;Seminal;Senior Scientist;Signal Transduction;Site;Specimen;stem-like cell;Surveys;Symptoms;Technology;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;translational research program;translational scientist;translational study;tumor;Tumor Bank;Tumor Biology;Tumor Cell Invasion;tumor growth;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Neuro-Oncology Program


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

PI_NAMEs: LOPRINZI, CHARLES L (contact)

PROJECT_TERMS: Acceleration;Adopted;Area;Biological Assay;Biometry;cancer care;Cancer Control;Cancer Control Research;cancer diagnosis;cancer prevention;cancer risk;Cancer Vaccines;Caring;Chemoprevention;Chemopreventive Agent;Clinic;Clinical;clinical practice;Clinical Research;Collaborations;Communities;Complement;Comprehensive Cancer Center;design;Development Plans;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;Ensure;Foundations;Funding;genetic epidemiology;genetic risk assessment;genome analysis;Goals;Grant;Health Policy;Imaging technology;improved;Incidence;innovation;Intervention;Investigation;Lead;Leadership;Life;liquid biopsy;Malignant Neoplasms;meetings;member;Neoplasms;Nicotine;novel;Organ;Peer Review;Pharmacy facility;Population Sciences;programs;Public Health;Publications;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;Risk Management;Risk Reduction;Schedule;Science;screening;Screening for cancer;Structure;survivorship;symptom management;Symptoms;tobacco control;tobacco exposure;Tobacco Use Cessation;Translations;tumor

PROJECT_TITLE: Cancer Prevention and Control


PI_NAMEs: CERHAN, JAMES R (contact)

PROJECT_TERMS: Acceleration;Address;Back;Bioinformatics;Biological Markers;Biology;Biometry;Breast;cancer epidemiology;Cancer Etiology;Cancer Prognosis;Cancer Survivorship;case control;Clinic;Cohort Studies;Collaborations;Colon;Comprehensive Cancer Center;Descriptive Epidemiology;design;Development;Epidemiologic Methods;Epidemiology;epidemiology study;Etiology;evidence base;Family;Funding;gene environment interaction;Genetic;genetic analysis;genetic epidemiology;genetic risk assessment;Genomics;Goals;Grant;Heterogeneity;Human;improved;Informatics;innovation;Integration Host Factors;Leadership;lifestyle factors;Literature;Lung;Malignant Neoplasms;Medical;Medical Informatics;member;Methods;Molecular;Molecular Analysis;Molecular Biology;Molecular Epidemiology;Molecular Epidemiology of Cancer;multidisciplinary;new technology;non-genetic;novel;Ovarian;Pancreas;Peer Review;Phenotype;Population;Precancerous Conditions;Prevention strategy;Primary Prevention;Prognosis;Prognostic Factor;programs;Prostate;Publications;Research;Research Design;Resolution;Resource Sharing;Risk Factors;risk stratification;Secondary Prevention;Serum;Statistical Methods;survivorship;Techniques;tertiary prevention;Translations;tumor;Tumor Markers

PROJECT_TITLE: Genetic Epidemiology and Risk Assessment Program


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: WILLMAN, CHERYL LYNN (contact)

PROJECT_TERMS: Advisory Committees;Advocate;anti-cancer research;Area;Arizona;Basic Science;cancer health disparity;Catchment Area;Characteristics;Clinic;Clinical Research;community advisory board;Community Outreach;Comprehensive Cancer Center;Education;education research;Environment;Evaluation;Family member;Florida;Fostering;Funding;Grant;Health system;Infrastructure;inter-institutional;Leadership;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Midwestern United States;NCI Center for Cancer Research;organizational structure;Patients;Population Sciences;Process;programs;Research;Research Activity;Resources;Role;Site;Strategic Planning;Training;Translational Research;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: NOWAKOWSKI, GRZEGORZ STANISLAW (contact)

PROJECT_TERMS: Address;Adverse event;Affect;Arizona;cancer clinical trial;Case Report Form;Catchment Area;cell growth;Cell Therapy;Child;chimeric antigen receptor T cells;Clinic;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collection;Complex;Comprehensive Cancer Center;Conduct Clinical Trials;Consent Forms;Data;Data Collection;data management;data quality;data quality/integrity;demographics;Development;Disease;Enrollment;Ensure;ethnic minority population;Florida;Funding;Grant;Growth;Health system;Immune checkpoint inhibitor;improved;Individual;Information Management;innovation;Institution;Institutional Policy;Institutional Review Boards;Intervention;Intervention Studies;Maintenance;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Midwestern United States;Minor;Minority;Monitor;novel;Office Management;Operations Research;participant safety;patient safety;Physician Executives;Police;Process;programs;Protocols documentation;racial minority;Recommendation;Records;Regulation;Reporting;Research Design;Research Personnel;Research Subjects;response;Rural Population;Safety;Services;Standardization;System;targeted treatment;Therapeutic;Time;Toxic effect;Training;trend;Underrepresented Populations;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: RELEVANCE (See instructions):  This project can lead to theoretical and experimental advances that will enhance our understanding of  epigenetic regulation in biological systems with broad implications in developmental biology and medicine.  The proposed framework provides the flexibility to test new mathematical theory and experimental  techniques, an aspect that transcends project specific objectives.

PI_NAMEs: BLERIS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adopted;Attention;Behavior;Benchmarking;biological systems;Calibration;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Analysis;computer framework;Coupled;CRISPR library;Custom;Data;design;Development;Developmental Biology;DNA cassette;Engineering;Epigenetic Process;epigenetic regulation;epigenetic silencing;experimental study;Feedback;flexibility;Gene Expression;gene regulatory network;Genes;Genetic Transcription;genome editing;Human;Human Cell Line;hybrid gene;in silico;Individual;inhibitor;Instruction;integrated circuit;Joints;Kinetics;Libraries;mathematical analysis;mathematical model;mathematical theory;Mathematics;Measurement;Medicine;Messenger RNA;Methodology;Methods;Modality;Modeling;models and simulation;Molecular and Cellular Biology;mRNA Expression;National Institute of General Medical Sciences;Phase Transition;Population;Population Statistics;predictive modeling;Property;protein expression;Proteins;Regulation;Relaxation;Research;response;single cell proteins;single molecule;Sorting;Stochastic Processes;synthetic biology;Techniques;Testing;theories;Time;Transcend

PROJECT_TITLE: DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-X (BM)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE (See instructions): Developing novel mathematical machinery to build simplified yet precise models towards learning and control of dynamic networks is imperative in biology. The research on developing lossless compression of intricate state-space representations of large-scale dynamic networks will create a new mathematical paradigm in data-rich biology. The findings may have profound implications for addressing timing-related disorders, including prevention and treatment of insomnias, shift-work disorder, seasonal affective disorder, and jetlag.

PI_NAMEs: LI, JR-SHIN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;animal old age;Animals;Area;Behavior;Biological;Biological Process;Biology;Body Temperature;Brain;Cell Cycle;Cells;chemical reaction;Chemistry;circadian;circadian biology;circadian pacemaker;Complex;Coupled;Coupling;Cues;Data;design;Disease;dynamic system;Eating;Economics;Engineering;environmental change;Epidemic;Event;Exhibits;Experimental Designs;Feedback;Formulation;gamma-Aminobutyric Acid;Gene Expression;Generations;Genetic Transcription;Genotype;Goals;Growth;Guidelines;Heterogeneity;Human;Hypothalamic structure;in silico;Individual;insight;Instruction;interest;Jet Lag Syndrome;juvenile animal;kernel methods;Label;Laws;Learning;learning network;learning strategy;Light;Mathematics;Measurement;Measures;Metabolism;Methods;Modeling;Motor Activity;National Institute of General Medical Sciences;Nature;network models;Neurons;Neurosciences;Nonlinear Dynamics;novel;Organism;Output;Pattern;Phase;Physiology;Population;Prevention;Process;Property;Protocols documentation;Recovery;Research;Research Personnel;Science;Seasonal Affective Disorder;Shapes;shift work;Shift-Work Sleep Disorder;Signal Transduction;Sleep;Sleep Fragmentations;sleep pattern;sleep syndrome;Sleeplessness;Social Network;social unrest;Societies;Space Models;Structure;suprachiasmatic nucleus;System;Techniques;Temperature;theories;tool;Translating;Translations;Uncertainty;Validation

PROJECT_TITLE: DMS/NIGMS 2: Moment Kernel Machines for Decoding Complexity in Dynamic Biological Networks


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE . Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with a very poor prognosis for patients who are diagnosed with relapsed or refractory (r/r) disease. Here we propose to test a promising treatment approach combining a clinical stage intravenously administered oncolytic Vesicular stomatitis virus (VSV) with a novel dually targeted checkpoint inhibitor (ONIx) in dogs with r/r DLBCL, to guide clinical development of this novel combination therapy for patients with r/r DLBCL. Detailed analyses to characterize the impact of combination therapy on the DLBCL tumor architecture and comparison of features of tumor microenvironment in responding versus nonresponding dogs will allow us to identify potential, clinically actionable biomarkers of response.

PI_NAMEs: MODIANO, JAIME F.;NAIK, SHRUTHI  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Agitation;anti-tumor immune response;Antigen Presentation;Architecture;Biological;biomarker identification;cancer heterogeneity;Canis familiaris;Cells;Chemotherapy-Oncologic Procedure;Clinic;Clinical;clinical development;Clinical Research;clinically actionable;cohort;Combined Modality Therapy;companion animal;comparative;Correlative Study;Cytolysis;Data;design;Diagnosis;Dose;Engineering;Gene Expression Profiling;Genomics;Heterogeneity;Hodgkin Disease;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;insight;Institution;Intravenous;intravenous administration;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Macrophage;Malignant Neoplasms;Measures;Mediating;Methods;Minnesota;Modeling;Mus;Mutation;nano-string;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Oncology;oncolytic Vesicular Stomatitis Virus;Oncolytic viruses;Outcome;Pathology;patient prognosis;patient response;Patients;Peptides;Phagocytosis;pre-clinical;Prognosis;prospective;Recurrent disease;Refractory;refractory cancer;Refractory Disease;Regimen;Relapse;Resistance;Resources;responders and non-responders;response;response biomarker;Safety;Sampling;single cell sequencing;Specimen;survival outcome;Systemic Therapy;T cell response;T-Lymphocyte;Testing;Therapeutic;tool;Toxic effect;Translations;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Vesicular stomatitis Indiana virus;Viral;virus development

PROJECT_TITLE: Translation of a novel combination therapy approach for non-Hodgkin lymphoma


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obesity and excessive fat consumption increase the risk of pancreatic cancer, but how they contribute to tumor development is not completely understood. In this proposal, we aim to determine how dietary fatty acids directly modulate pancreatic lipid composition to drive the formation of one of the most lethal and incurable cancers. Results from this study may lead to novel targeted dietary and pharmacologic strategies for the prevention of pancreatic cancer and possibly other obesity-driven cancers.

PI_NAMEs: MUZUMDAR, MANDAR DEEPAK (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: 3-Dimensional;Acceleration;Acinar Cell;Adipose tissue;Albumins;Binding;cancer care;Cancer Etiology;Cell Culture System;Cell model;Cells;Cessation of life;cohort;conditional knockout;Consumption;Country;Cultured Cells;Data;Development;Diet;Diet Research;dietary;dietary approach;dietary excess;Dietary Fats;Dietary Fatty Acid;driving force;Duct (organ) structure;Ductal Epithelial Cell;experimental study;FASN gene;Fatty acid glycerol esters;Fatty Acids;feeding;Genes;Genetic;Genetic Models;Genetically Engineered Mouse;Goals;Health;High Fat Diet;Histologic;Human;human disease;In Vitro;in vitro Model;in vivo;inhibitor;Intake;Integration Host Factors;Isotopes;Knock-out;KRAS oncogenesis;Link;Lipase;lipid metabolism;lipidomics;Lipids;long chain fatty acid;Lysophospholipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane;Metabolic;Metaplasia;Methods;Modeling;Monounsaturated Fatty Acids;Mus;non-genetic;Nonesterified Fatty Acids;novel;Obesity;Oleic Acids;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Pathway interactions;pharmacologic;Phospholipids;Plasma;Population;premalignant;Prevalence;Prevention strategy;Process;Production;Radioactive;Radioisotopes;receptor;Risk;Side;Source;Supplementation;Survival Rate;Testing;Time;Tissues;Tracer;tumor;tumor progression;tumorigenesis;tumorigenic;United States;Up-Regulation;uptake;Variant;Work

PROJECT_TITLE: Dietary fatty acids drive pancreatic cancer development

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Leukemia remains difficult to treat, indicating an urgent need to develop new therapeutic strategies; thus, the overarching goal of the proposed research is to explore leukemia metabolism and develop novel biomarkers and therapeutic strategies. Our preliminary data demonstrates that specific metabolic pathways driving serine biosynthesis are increased in leukemia; these reflect vulnerabilities that we can develop imaging biomarkers to target. Our proposed work will facilitate future patient-specific treatment planning and novel experimental strategies for cancer treatment.

PI_NAMEs: KESHARI, KAYVAN R (contact);KHARAS, MICHAEL

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Anabolism;Automobile Driving;Biological Markers;cancer therapy;Carbohydrates;Carbon;Cell Compartmentation;cell growth;Cell Line;Cells;Cellular Metabolic Process;chemotherapy;Clinical;Collaborations;Companions;Complex;Data;dehydroascorbate;Dependence;design;Development;Diet;Disease;Environment;Enzyme Inhibition;Enzymes;FLT3 gene;Future;Genetic;Genetic Variation;Glucose;Glutamine;Glycolysis;Goals;Hematopoietic;Heterogeneity;Human;human cord blood CD34+ cell;Image;imaging approach;imaging biomarker;in vivo;individualized medicine;innovation;insight;Isocitrate Dehydrogenase;Isotopes;Knowledge;leukemia;leukemic stem cell;Link;Lipids;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;mass spectrometric imaging;Measures;Mediating;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;MLL-AF9;Modeling;Motivation;Mus;Mutation;Myeloid Leukemia;new therapeutic target;novel;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient;Organism;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphoglycerate dehydrogenase;programs;Publishing;Pyruvate;Relapse;Research;Resistance;response;Role;Sampling;Science;Serine;Sorting;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem cell biology;stem cells;stemness;stress state;Therapeutic;therapeutic development;therapy resistant;tool;Translating;treatment planning;treatment response;tumor metabolism;Visualization;Work

PROJECT_TITLE: Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


PHR: NARRATIVE This project will investigate the use of proton pencil beam scanning (PBS) to deliver FLASH enhanced radiotherapy. The approach will examine the complex interplay between spatio-temporal beam parameters and FLASH, optimization algorithms for modeling biological effects and treatment planning, and development of FLASH specific methods for ultra-fast dose monitoring, robotic positioning, image guidance, and quality assurance. The goal is to further optimize the FLASH effect by PBS machine tuning and FLASH delivery with existing clinical proton accelerator technology.

PI_NAMEs: WIERSMA, RODNEY  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Algorithms;Animal Experiments;Animals;beamline;Biological;Biological Models;Biology;Blood capillaries;Canis familiaris;Clinical;clinical implementation;Complex;Computer software;design;Development;Diffusion;Dose;Dose Rate;Ensure;experience;experimental study;Future;Gamma Rays;Goals;image guided;instrumentation;Investigation;Ions;irradiation;Linear Energy Transfer;Location;Measurement;Measures;Methodology;Methods;Modeling;Modernization;Monitor;Mus;Nature;Normal tissue morphology;Outcome;Outcome Measure;Outcome Study;Overdose;Oxygen;particle;particle beam;Patients;Phase I Clinical Trials;Physiologic pulse;Plug-in;Positioning Attribute;preclinical study;prevent;Procedures;proton therapy;Protons;quality assurance;Radiation;Radiation therapy;Radiobiology;Reactive Oxygen Species;Research;Resolution;Robotics;Safety;Scanning;spatial temporal variation;spatiotemporal;Speed;Structure;success;System;Tail;Techniques;Technology;Testing;Time;Tissues;tool;translational study;Translations;transmission process;treatment planning;tumor;Validation;Variant;Vascular blood supply;Vendor

PROJECT_TITLE: Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Lymphatic Research;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Durable antitumor immunity requires presentation of tumor antigens by professional antigen presenting cells (APCs) for priming of antitumor T cell responses, but APC function is repressed in the immunosuppressive tumor microenvironment. This project will decipher the mechanisms of the unique immune stimulation provided by recombinant poliovirus, resulting from non-lethal infection and pro-inflammatory activation of APCs. The significance of this research is the potential to achieve significant clinical benefits for cancer patients by reinstating tumor immune surveillance.

PI_NAMEs: GROMEIER, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adoptive Transfer;Antigen-Presenting Cells;Antigens;antitumor effect;Attenuated;Autopsy;Brain;Brunhilde Virus;cancer immunotherapy;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cells;Cervical lymph node group;Chemotaxis;Clinical;Clinical Trials;Cross Presentation;Cytoplasm;cytotoxic;Dendritic cell activation;Dendritic Cells;Disease;Double-Stranded RNA;Engineering;Focal Infection;gastrointestinal;Glioblastoma;Glioma;glymphatic system;Human;Human poliovirus;IFIH1;Immune;immune checkpoint blockade;Immunity;Immunologic Stimulation;Immunologic Surveillance;Immunology;Immunotherapy;imprint;In Vitro;in vivo;Infection;Infiltration;Inflammatory;Injections;insight;Interferon Type I;Interferons;Internal Ribosome Entry Site;Investigation;ITGAM gene;ITGAX gene;lymph nodes;Lymphatic System;lymphoid structures;Lymphoid Tissue;Macaca;Macrophage;Malignant Neoplasms;Mediating;Melanoma;migration;Modeling;Mononuclear;Mus;Myelogenous;Myeloid Cells;Natural Killer Cells;Necrosis;Nodal;Non-Malignant;Normal Cell;Oral;Outcome;Pan Genus;pathogen;Pathogenicity;patient subsets;Patients;Pattern;Pattern recognition receptor;Peripheral;Phagocytes;radiological imaging;Reaction;Receptor Signaling;Recombinants;recruit;Recurrence;Reporting;Repression;Research;Resistance;Resolution;response;Rhinovirus;RNA Viruses;Role;safety study;Schedule;sensor;Signal Transduction;Site;Slice;spatiotemporal;Spleen;Stimulus;T cell response;T-Lymphocyte;TAP1 gene;Testing;trafficking;translational study;Tropism;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Vaccines;Viral;Virulence;Virus;Widespread Disease

PROJECT_TITLE: Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE We seek to design a potent dual action immunostimulatory nanoparticle that reprograms and activates the innate immune cells because these cells recruit systemic immunity. Such approach can facilitate an antitumor immune response leading to tumor rejection and prevention of disease relapse.

PI_NAMEs: KARATHANASIS, EFSTATHIOS  (contact);WANG, LI LILY

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adverse event;Agonist;anti-tumor immune response;cancer immunotherapy;Cells;cytotoxic CD8 T cells;design;Disease;disorder prevention;Disseminated Malignant Neoplasm;dosage;Ensure;environmental enrichment for laboratory animals;Frequencies;Gene Activation;Genes;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;Immunoglobulin Domain;Immunologic Memory;Immunotherapy;in vivo;innovation;Lipids;lymphocyte trafficking;Malignant Neoplasms;Mediating;Melanoma;Metastatic breast cancer;Metastatic/Recurrent;Methods;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;Natural Immunity;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Operative Surgical Procedures;Patients;programmed cell death protein 1;programs;Proteins;recruit;recurrence prevention;Recurrent disease;Recurrent tumor;Resistance;response;Safety;side effect;siRNA delivery;Small Interfering RNA;Solid Neoplasm;stem;Suppressor-Effector T-Lymphocytes;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;Treatment Efficacy;tumor;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor Volume;tumor-immune system interactions;uptake

PROJECT_TITLE: Dual action immunostimulatory nanoparticles for treatment of aggressive cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative While some patients with pancreatic cancer are living longer, additional approaches, including combinatorial therapies against new targets are needed. Therefore, we propose to investigate a validated therapeutic target, Redox factor-1 (Ref-1), alone and in combinations that selectively kill the tumor by impinging on critical pathways the tumor is using to survive. After advancing the first-generation Ref-1 inhibitor (APX3330) to a phase I clinical trial in adult patients, we have identified next generation Ref-1 inhibitors, a strategy to screen for patients that have sensitivity to Ref-1 inhibition, and molecular targets that are likely to synergize with Ref-1 inhibition.

PI_NAMEs: FISHEL, MELISSA L.;KELLEY, MARK R. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Adult;advanced disease;analog;Bioinformatics;cancer cell;candidate selection;carbonate dehydratase;Cell Line;Cell Proliferation;Cells;Characteristics;Citric Acid Cycle;Clinical;clinical development;Clinical Trials;Coculture Techniques;combinatorial;Combined Modality Therapy;Critical Pathways;Data;design;Development;Disease;disorder control;Dose;Drug Combinations;Drug resistance;Enzymes;Evaluation;Future;Gene Expression;Generations;Genes;Genetic Transcription;Growth;Hypoxia;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Investigational Drugs;knock-down;Lead;lead candidate;lead optimization;Malignant neoplasm of pancreas;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Mitochondria;Molecular Target;Mus;Neoplasm Metastasis;next generation;novel;novel therapeutics;nutrient deprivation;Organoids;Outcome;Oxidation-Reduction;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;patient derived xenograft model;patient screening;Patients;personalized approach;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Play;pre-clinical;preclinical development;programs;Proliferating;Reaction;Resistance;resistance mechanism;response;Role;Signal Transduction;Signaling Protein;Solid Neoplasm;spheroids;synergism;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;Toxic effect;transcription factor;Treatment Efficacy;Triage;trial design;tumor;tumor growth;tumor metabolism;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer


NIH_SPENDING_CATS: Cancer;Genetics;Radiation Oncology

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE. Chromosomal-breaking agents (i.e. clastogens), including ionizing radiation, remain a cornerstone of cancer therapy; nevertheless, their efficacy could be improved by inhibiting the repair of chromosomal breaks in cancer cells. Indeed, inhibitors of the DNA-dependent protein kinase catalytic subunit (DNAPKcs) are being developed for this approach; but to identify the ideal contexts for using such inhibitors, it is critical to understand the role of DNAPKcs in chromosomal break repair. Thus, our proposed studies to elucidate the mechanisms of DNAPKcs function during chromosomal break repair will support the mission of the NIH to improve cancer treatments and patient outcomes.

PI_NAMEs: STARK, JEREMY MICHAEL (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Binding;Biological Assay;Biological Markers;biomarker development;cancer cell;cancer therapy;Cells;Chromosomal Breaks;Chromosomes;clastogen;Clinical Trials;Code;cofactor;Combined Modality Therapy;Complex;Data;Defect;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA replication fork;DNA-dependent protein kinase;DNA-PKcs;Double Strand Break Repair;Ensure;Event;experimental study;G22P1 gene;Genetic;Genome;Genome Stability;Genomic Instability;Human;improved;inhibitor;innovation;insertion/deletion mutation;insight;Ionizing radiation;kinase inhibitor;Laboratories;Lasers;Ligase;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Mission;Modeling;mutant;Mutation;Nonhomologous DNA End Joining;novel;nuclease;Outcome;Pathway interactions;Patient-Focused Outcomes;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;PRKDC gene;PTEN gene;radiation resistance;Radiation therapy;recruit;Regulation;repaired;replication stress;Reporting;Resistance;response;response biomarker;Ribosomal RNA;RNA Processing;Role;scaffold;Series;Signal Transduction;Site;synergism;Technology;Testing;therapeutic target;Time;Treatment outcome;Treatment Protocols;treatment strategy;tumor;Tumor Suppressor Proteins;United States National Institutes of Health;V(D)J Recombination;XRCC4 gene;XRCC5 gene

PROJECT_TITLE: Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Because blood cancers are exquisitely sensitive to radiation, targeted radiation delivery via radioimmunotherapy (radionuclides stably linked to target-specific antibodies) has gained interest with a commensurate increase in radioimmunotherapy clinical trials. Although clinical efficacy has been observed in stand-alone radioimmunotherapy for cancers, or as part of conditioning regimens prior to allogeneic hematopoietic stem cell transplantation, how the normal bone marrow niche differentially responds radioimmunotherapy compared to conventional approaches is not well-understood, limiting potential interventions to mitigate the negative effects from radiation to the marrow. This proposal will address current limitations and identify how to modulate specific bone marrow niche alterations for desired clinical goals by identifying how the hematopoietic stem cells, vascular endothelial cells and stromal cells in the bone marrow niche respond to radioimmunotherapy with an alpha- emitter (astatine-211), beta-emitter (yttrium-90), or X-ray radiation, as gauged by stem cell functional assays, architecture restructuring using microscopy, and differential gene expression from RNA sequence analysis.

PI_NAMEs: OROZCO, JOHNNIE JOSE (contact);TERMINI, CHRISTINA MARIE

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;90Y;Acceleration;Acute leukemia;Address;Allogenic;Antibodies;Architecture;Area;Astatine;Bioinformatics;Biological Assay;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell Transplantation;cadherin 5;Cancer Patient;cancer radioimmunotherapy;cancer therapy;Cell Compartmentation;Cell surface;Cells;Cessation of life;Characteristics;Chemotherapy and/or radiation;Clinical;clinical efficacy;Clinical Trials;conditioning;confocal imaging;Confocal Microscopy;Coupled;Data;Diameter;Endothelial Cells;Erythrocytes;experimental study;Exposure to;Femur;fibroglycan;Flow Cytometry;Frequencies;Future;Gene Expression Profile;Genetic Transcription;Goals;Grant;Half-Life;Harvest;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hour;Image;improved;in vivo;interest;Intervention;irradiation;Knowledge;Length;leptin receptor;leukemia;Leukocytes;Link;Maps;Marrow;Measures;microscopic imaging;Microscopy;Molecular;Multiple Myeloma;Mus;Myelogenous;Natural regeneration;new therapeutic target;Organ;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PECAM1 gene;Perfusion;physical model;Population;Proliferating;Provider;PTPRC gene;Radiation;radiation delivery;radiation effect;Radiation exposure;Radiation Injuries;Radiation therapy;Radiation Toxicity;Radioactive Elements;Radioimmunotherapy;Radioisotopes;Radionuclide therapy;Recovery;Regimen;repaired;Reporting;Residual state;response;Risk;RNA Sequence Analysis;Roentgen Rays;Role;self renewing cell;self-renewal;Signal Transduction;Source;stem cell function;stem cell proliferation;stem cells;Stromal Cells;Structure;Supporting Cell;Surface;System;Systemic Therapy;Technology;Thick;Time;Tissue-Specific Gene Expression;tool;Toxic effect;Traction;transcriptome sequencing;Transplantation;Vascular Endothelial Cell;x-ray irradiation

PROJECT_TITLE: Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations


NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: PISCATAWAY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: RELEVANCE (See instructions): The rapid advancement of machine learning has fundamentally transformed the field of biology and medicine. In this proposal, we will develop new interpretable statistical methodology to advance medical genetic. The methods developed could revolutionize biology with Al and machine learning assistance, and provide foundational perspectives to blend the computational sciences and biomedical research.

PI_NAMEs: WANG, SIJIAN ;XIE, MINGE ;XING, JINCHUAN ;XU, MIN  (contact)

PROJECT_TERMS: Bioinformatics;Biology;Biomedical Research;Candidate Disease Gene;Cell Physiology;Communities;Complex;Computational Science;Data;Data Science;Development;Disease;Evolution;flexibility;gene discovery;gene interaction;Gene Mutation;gene network;Genes;Genetic;Genetic Predisposition to Disease;Genetic Research;Goals;Growth;Information Networks;innovation;Instruction;laboratory experiment;Machine Learning;Medical Genetics;Medicine;Methodology;Methods;Modeling;National Institute of General Medical Sciences;network models;novel;Pathway Analysis;Pathway interactions;Patients;Process;Research;Sampling;Structure;Time;Uncertainty;Work

PROJECT_TITLE: DMS/NIGMS 1: Disease gene discovery by Markovian gene network

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-A (BM)]


NIH_SPENDING_CATS: Bioengineering;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: RELEVANCE (See instructions): Cell growth, division, and fate selection are fundamental mechanisms across biological systems, and a quantitative understanding of stem cell dynamics in Ceratopteris has the potential to provide insight into animals and humans. This knowledge can eventually support the development of stem cell-based approaches to treat human disease or regenerate damaged human tissue. The mathematical methods and code built in this project will be a transferrable tool for learning cell behavior from data in other systems.

PI_NAMEs: VOLKENING, ALEXANDRIA  (contact);ZHOU, YUN

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Animals;Binding;biological systems;Building Codes;cell behavior;Cell Count;Cell division;cell growth;Cell model;Cell Nucleus;Cell Shape;Cells;Cellular Structures;Chemicals;Collaborations;confocal imaging;Coupling;Data;Defect;Development;Disease;Equation;Experimental Designs;experimental study;Feedback;Ferns;Functional disorder;Genetic;Goals;Growth;Heart;high risk;Hormones;Human;human disease;human tissue;Hybrids;Image;in silico;in vivo;Individual;insight;Instruction;interdisciplinary approach;Knowledge;Learning;learning strategy;live cell imaging;mathematical methods;mathematical model;Mechanics;Meristem;Methodology;Methods;model design;Modeling;Molecular;Morphology;Motion;multi-scale modeling;Natural regeneration;notch protein;Organ;Organism;particle;Plants;predictive modeling;Regulatory Pathway;Reproduction;Research;Resolution;Role;Series;Shapes;Signaling Molecule;spatiotemporal;stem cell based approach;Stem Cell Development;stem cells;Structure;System;Testing;Tissues;tool;Work

PROJECT_TITLE: A bio-math approach to elucidate stem cell dynamics in Ceratopteris gametophytes


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: RELEVANCE (See instructions): The proposed statistical methods will generate valuable insights into how a microbe interacts with other microbes, its host, and the environment. These insights could deepen our understanding of how the microbiome affects human health or the environment, and ultimately could lead to the development of microbiome-directed interventions aimed at improving health status.

PI_NAMEs: LEE, JU HEE  (contact)

PROJECT_TERMS: Address;Affect;Bayesian Method;Bayesian Modeling;Benchmarking;Big Data;Biological;Biological Process;Collaborations;Complex;Computational algorithm;Data;Data Analyses;data integration;data repository;Data Set;Dependence;Development;diagnostic tool;Disease Management;Ensure;Environment;Environmental Risk Factor;Evolution;flexibility;Formulation;Foundations;Health;health management;Health Status;high dimensionality;High-Throughput Nucleotide Sequencing;Human;Human Microbiome;improved;innovation;insight;Instruction;Integration Host Factors;Intervention;Joints;Knowledge;Letters;Los Angeles;Methodology;Methods;Microbe;microbial;microbial community;microbiome;microbiome research;microbiome sequencing;microorganism interaction;Modeling;Monitor;multidimensional data;Multiomic Data;multiple omics;National Institute of General Medical Sciences;Noise;novel;Process;Property;Research;Role;Sample Size;Sampling;semiparametric;Signal Transduction;Statistical Methods;Structure;Techniques;Time;tool;Uncertainty;United States National Institutes of Health;user friendly software;Validation;vector

PROJECT_TITLE: DMS/NIGMS 2: Bayesian Statistical Methods for Comprehensive Inferences on Microbial Community Dynamics Using High-Throughput Sequencing Data


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: UTRECHT

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: PRINSES MAXIMA VOOR KINDERONCOLOGIE, BV

PI_NAMEs: WIENKE, JUDITH  (contact)

PROJECT_TERMS: Affinity;age group;Antineoplastic Agents;aspirate;Binding;Boston;Brain;CAR T cell therapy;CD276 gene;Cell Physiology;Chemicals;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;clinical implementation;clinical translation;Clinical Trials;clinically relevant;Combination immunotherapy;CRISPR/Cas technology;Cytostatics;Dependence;design;Development;Disease;Drug Controls;drug development;Drug Targeting;drug testing;early phase clinical trial;engineered T cells;Engineering;Ependymoma;Equilibrium;Evaluation;Ewings sarcoma;exhaustion;Functional disorder;Funding;Glioma;immune modulating agents;immunoregulation;improved;inhibitor;innovation;insight;Interphase Cell;Intervention;Investigation;Legal patent;lenalidomide;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Methods;Modeling;mortality;Neuroblastoma;novel;Oncogenic;Oncoproteins;orphan nuclear receptor ROR-gamma;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physiologic pulse;pre-clinical;Printing;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;receptor expression;receptor function;Receptor Signaling;Recovery;Regulation;Research Personnel;Resistance;resistance mechanism;Rest;Risk;screening;Solid;Solid Neoplasm;structural biology;success;Survival Rate;synovial sarcoma;T-Lymphocyte;Technology;Thalidomide;Therapeutic;translational potential;tumor;Tumor Biology;tumor growth;ubiquitin-protein ligase;Zinc Fingers

PROJECT_TITLE: PROTECT - Harnessing PROTEin degradation for Advanced Childhood Tumors


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This study will identify multi-level (e.g., individual, household, neighborhood, school/community) correlates and consequences of food insecurity in households (n=627) with racially/ethnically diverse children ages 5-16. Using mixed-methods (e.g., ecological momentary assessment (EMA), biomarkers, Geographical Information Services (GIS) data, focus groups), this study will examine when and how cardiometabolic risk emerges from food insecurity in childhood, mechanisms/pathways between food insecurity and cardiometabolic health, and multi-level factors that buffer against or exacerbate food insecurity to inform multi-sector interventions.

PI_NAMEs: BERGE, JERICA M (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;Age;Biological Markers;Body Composition;Body fat;Body measure procedure;Buffers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Child;Child Behavior;Child Health;Child Rearing;Childhood;cohort;Communities;community organizations;community setting;coping;COVID-19;COVID-19 pandemic effects;cytokine;Data;design;Development;Diet;dietary;Disparity;Ecological momentary assessment;economic impact;Environment;ethnic diversity;experience;Exposure to;Family;feeding;Focus Groups;Food;food environment;food insecurity;Functional disorder;Future;Geography;Health;Health behavior;Health Personnel;Healthcare;Household;Hydrocortisone;improved;Individual;Inflammation;Information Services;innovation;Intervention;Knowledge;Life;longitudinal, prospective study;Low income;Measurement;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Methodology;Methods;Morbidity - disease rate;mortality;Neighborhoods;nutrition;Obesity;obesity in children;obesity risk;Oxidative Stress;pandemic disease;Parenting Education;Parents;Pathway interactions;Personal Satisfaction;Physical activity;Physiology;Policies;Policy Developments;prevent;Price;prospective;Prospective Studies;protective factors;Puberty;Public Health;racial diversity;Resources;Risk;Risk Factors;Role;Schools;Science;Secure;Severities;Sleep;Staging;Stress;Stressful Event;Structural Racism;Surveys;therapy development;Time

PROJECT_TITLE: Examining Pathways Between Food Insecurity and Cardiometabolic Health in Diverse Children and Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Binge drinking is common among young adults and is related to many negative health outcomes including blackouts, risky sex, drunk driving, alcohol use disorder, and liver disease. The proposed study will compare behavioral and neural processing of alcohol and non-alcohol cues in a single sensory modality (vision) with that of cues presented in multiple sensory modalities (vision, touch, and smell) with varying degrees of realistic appearance (images, virtual reality, real objects). Given that most alcohol cues in daily life are experienced across multiple senses simultaneously, results of this research will provide a better understanding of the relation between alcohol cue processing and craving, and will inform development of more effective programs for decreasing young adult risky drinking behavior.

PI_NAMEs: FEDOROVSKAYA, ELENA ;HOUSTON, REBECCA J (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: 3-Dimensional;3D virtual reality;Acute;Addictive Behavior;Address;Age;aged;Alcohol abuse;Alcohol consumption;alcohol craving;alcohol cue;alcohol effect;alcohol response;alcohol use disorder;Alcohols;Appearance;Area;Behavior;Behavioral;binge drinker;binge drinking;biobehavior;Chronic;craving;cue reactivity;Cues;Development;drinking behavior;Drunk driving;Effectiveness;Electrophysiology (science);Environment;Event-Related Potentials;experience;Exposure to;Extinction;Goals;Health;high risk drinking;Image;improved;innovation;insight;Intervention;Learning;Life Experience;Liver diseases;Modality;multisensory;Nature;neural;Neurocognitive;novel;novel strategies;Outcome;Participant;Patient Self-Report;Pattern;Persons;programs;Public Health;Reaction Time;recruit;Reporting;Research;response;Risk;sample fixation;Sensory;sex;simulation;Smell Perception;social;Stimulus;Tactile;Technology;therapy development;Time;Touch sensation;two-dimensional;undergraduate student;vehicular accident;virtual reality;virtual reality environment;virtual reality simulation;Vision;Visual;Work;young adult

PROJECT_TITLE: Multisensory Processing of Alcohol Cues in Young Adult Binge Drinkers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal describes a research program with the major objective of identifying processes that show promise during high pressure activation, by systematic scanning of a broad range of reactions by theoretical and experimental means; to use calculations to determine whether the reactions would be stimulated by HHP and then experimentally confirm the results.

PI_NAMEs: TOROK, BELA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Acetaminophen;Affect;Analgesics;Aspirin;Atmosphere;Benzodiazepines;catalyst;Classification;Data;Data Analyses;drug candidate;Drug Industry;drug synthesis;Equipment;experimental study;Food Industry;Funding;Future;Goals;Hydrazones;Hydrostatic Pressure;improved;improved outcome;in silico;Industrialization;Investigation;Methods;Organic Synthesis;Pharmacologic Substance;pressure;Process;programs;Protocols documentation;Pyrazoles;Reaction;Reaction Time;Research;scale up;Scanning;screening;Solvents;Technology;Temperature;Testing;text searching;theories;Time

PROJECT_TITLE: Green Synthesis of Building Blocks and APIs by High Hydrostatic Pressure-initiated Synthesis

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Climate-Related Exposures and Conditions

ORG_CITY: UNIVERSITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative This research aims to unravel the sophisticated mechanisms by which the 70-kilodalton heat shock protein (HSP70) influences cellular stress responses and disease pathways through its interaction with carbohydrates and calcium/calmodulin. By exploring HSP70’s structural features and their impact on cellular functions using Arabidopsis as a model system, the project will contribute significantly to our fundamental understanding of protein homeostasis and its role in health and disease. Ultimately, the insights gained could lead to the development of novel therapeutic strategies aimed at modulating HSP70 pathways, offering the potential to enhance health, extend life, and mitigate various illnesses.

PI_NAMEs: QIU, YONGJIAN  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Affinity Chromatography;analog;angiogenesis;Animals;Arabidopsis;ATP phosphohydrolase;base;Binding;biological adaptation to stress;Biological Markers;Biological Models;biological research;Breast Cancer Cell;Calcium;Calcium Binding;Calmodulin;Cancer Biology;Carbohydrates;Cardiovascular Diseases;Cell Physiology;Cellular Stress;Characteristics;Client;clinical application;Communicable Diseases;Complex;Coupled;Cytoplasm;Defense Mechanisms;Development;Disease;Disease Pathway;Effectiveness;Exhibits;extracellular;Extracellular Space;Family;glycosylation;Goals;Health;Heat shock proteins;Heat Stress;Heat-Shock Proteins 70;Human;human disease;Human Pathology;Hydroxyproline;Immune response;immunoregulation;improved;in vivo;innovation;insight;interest;Investigation;Label;Lectin;Life;Life Cycle Stages;Link;Malignant Neoplasms;Mammals;Mediating;Metabolic Pathway;Methods;Missense Mutation;Mission;Modeling;Molecular Chaperones;Molecular Target;Mutation;Nature;Neoplasm Metastasis;Nerve Degeneration;novel;novel therapeutic intervention;Nucleotides;Nutritional;operation;Organism;Pathogenesis;Pathology;Pathway interactions;Peptides;Physiological;Plants;Play;Positioning Attribute;Post-Translational Protein Processing;Property;protein folding;Protein Glycosylation;Protein Isoforms;Proteins;proteostasis;Reader;Recombinants;Regulation;Research;resilience;response;Role;Signal Transduction;Specificity;Stress;stress resilience;stress tolerance;Structure-Activity Relationship;System;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;therapy development

PROJECT_TITLE: Regulation of HSP70 function during heat stress tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (81)]


ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Fluid build-up in the lungs is a severe medical condition seen in such conditions as heart failure and can make it difficult to breath and lead to death. We believe that the tension sensed in the cells lining the blood vessels of the lungs is an important contributor to this condition. The research in this proposal will help us understand how this tension leads to excess fluid in the lungs and hopefully lead to better treatments for patients with congestive heart failure.

PI_NAMEs: KOMAROVA, YULIA A (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Adherens Junction;Blood capillaries;Blood Vessels;cadherin 5;Cell Line;Cell membrane;Cessation of life;Congestive Heart Failure;Data;Edema;Endocytosis;Endothelial Cells;Endothelium;Exposure to;Failure;Fluid Balance;Goals;Health;Heart failure;Host Defense;Hydrostatic Pressure;Lead;Left;Link;Liquid substance;Lung;lung failure;mechanical force;Mediating;Medical;Microvascular Permeability;migration;new therapeutic target;Patients;Permeability;Phosphorylation;Piezo 1 ion channel;pressure;Proteins;Pulmonary Edema;Research;response;Role;Signal Pathway;Signal Transduction;Stress;Time

PROJECT_TITLE: Programming of PMN host-defense function during transendothelial migration. Research supplement to promote diversity in health-related research

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Digestive Diseases;Food Allergies;Infectious Diseases;Nutrition;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The syndrome of delayed anaphylaxis to red meat is common across a large area of the southeast and the ability to identify cases by measuring IgE antibodies to alpha-gal is central to preventing further episodes. The studies described here are designed to provide further understanding about the role of ticks bites in instigating and promoting the sensitization that forms the basis of this novel form of food allergy. The recent preliminary evidence about a connection with coronary artery disease suggests that this form of sensitization may have major public health significance beyond urticaria and anaphylaxis.

PI_NAMEs: PLATTS-MILLS, THOMAS A. (contact);WILSON, JEFFREY M

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Allergic Disease;alpha-gal syndrome;Amblyomma;Anaphylaxis;Antibodies;Antibody Response;Area;Biological;Biological Products;Blood Vessels;Cardiovascular Surgical Procedures;Cattle;Clinical;Cohort Studies;Collaborations;Communities;Coronary Arteriosclerosis;Country;design;Disease;Epidemiology;Etiology;Failure;Family suidae;Food Hypersensitivity;galactosyl-(1-3)galactose;Goals;IgE;Immunoglobulin G;Immunologics;Immunology;implantation;Individual;Inflammatory;longitudinal, prospective study;Measures;Meat;Natural History;novel;Oligosaccharides;Parents;Patients;prevent;prospective;Public Health;Recording of previous events;Research;Risk;Role;Serum;Syndrome;tick bite;Ticks;Time;Urticaria

PROJECT_TITLE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE The identification of genes involved in proper development and function of the reproductive system is essential to inform medical efforts that support reproductive health. We approach this challenge by taking advantage of a surging model organism in studies of regenerative biology, the planarian Schmidtea mediterranea. Due to the ease of functional genetic analysis by RNA-interference in these organisms, the shared conserved processes involved in germ cell development with vertebrates, and their exceptional ability to continuously regenerate their entire reproductive system from pluripotent stem cells, this approach will reveal genetic components required for proper development and function of sperm and eggs.

PI_NAMEs: ROUHANA, LABIB  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3' Untranslated Regions;Address;Adult;Anatomy;Animals;Award;Biochemical;Biology;Boston;Caenorhabditis elegans;Cell Differentiation process;Cell Nucleus;Cells;Cilia;Cleavage And Polyadenylation Specificity Factor;Clinical;cofactor;Contraceptive Agents;CPE-binding protein;Creativeness;Cytoplasm;Data;Development;Developmental Process;Double-Stranded RNA;Drosophila melanogaster;egg;Embryonic Development;Ensure;Environment;Event;experience;experimental analysis;experimental study;falls;feeding;Female;fly;Gametogenesis;gene discovery;Gene Expression;gene function;Genes;Genetic;genetic analysis;Genetic Screening;Germ Cells;Germ Lines;germline stem cells;Goals;Gonadal structure;Individual;Infertility;insight;knock-down;Knowledge;KRP protein;Maintenance;male;Mammals;Massachusetts;Mediating;Medical;Messenger RNA;model organism;Modeling;Molecular;Molecular Biology;molecular marker;mRNA Precursor;mRNA Stability;mRNA Translation;Mus;Natural regeneration;Nematoda;neuronal cell body;Nuclear;Organism;Orthologous Gene;Outcome;Ovary;Pathology;Pathway interactions;Phenotype;Planarians;Platyhelminths;Play;Pluripotent Stem Cells;Polyadenylation;Post-Transcriptional Regulation;Postembryonic;Process;Production;Productivity;programs;Protein Isoforms;Proteins;Protocols documentation;Publishing;recruit;regenerative biology;Regenerative research;Regulation;Reproductive Biology;reproductive function;Reproductive Health;Reproductive system;Research;Research Personnel;RNA Interference;Role;Secure;sex;Shapes;Signal Transduction;Site;Specific qualifier value;sperm cell;sperm function;Sperm Head;Spermiogenesis;Stem Cell Development;Stem Cell Research;student participation;Students;Testis;Tissues;Totipotent;transcription termination;transcriptomics;undergraduate research experience;undergraduate student;Universities;Vertebrates;virtual;Work;zygote

PROJECT_TITLE: Discovery of germline genes and regulatory networks in planarians


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MERCED

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: Project Narrative Dysfunctions in motor protein-based transport are a common and early hallmark in many diseases, notably neurodegeneration. This project examines a crucial molecular mechanism that could underlie dysfunctions in motor protein function. Findings could pave the way for future therapeutics to mitigate dysfunctions early in disease progression.

PI_NAMEs: XU, JING  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Aging;Binding;Binding Sites;Biological Assay;career;Cell Physiology;Cell Survival;Cells;Cholesterol;computational platform;Data;density;Detection;detection method;Diffuse;Diffusion;Disease;Disease Progression;environmental enrichment for laboratory animals;Eukaryotic Cell;fluidity;Functional disorder;Funding;Future;Goals;improved;In Vitro;in vitro Assay;in vivo;insight;Institution;Intracellular Transport;Investigation;Kinesin;Kinetics;Knowledge;Lasers;Link;Lipids;Liquid substance;Manuscripts;mathematical model;Measures;Membrane;Membrane Fluidity;Membrane Lipids;Microtubule Polymerization;Microtubules;Modeling;models and simulation;Molecular;Motor;Nature;Nerve Degeneration;optic trap;optical traps;Peer Review;Physiological;Positioning Attribute;Preparation;Probability;Process;Productivity;Property;protein function;Proteins;Publications;Regulation;Research;Science;Scientific Advances and Accomplishments;simulation;Spatial Distribution;Surface;tau Proteins;temporal measurement;Testing;Therapeutic;therapeutic target;Time;tool;Transmembrane Transport;two-dimensional;undergraduate student;Work

PROJECT_TITLE: Determining the impact of cargo membrane fluidity on motor protein function

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Kidney Disease;Patient Safety

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Kidney disease is common in patients with heart failure and associated with increased risk of death, heart problems, and hospitalizations. It is important to identify biomarkers that can be easily tested from the blood that are associated with worsening kidney disease and death in patients with heart failure to understand (a) who is at risk for these adverse outcomes and (b) the mechanisms behind kidney disease in heart failure. This study will test certain biomarkers – cystatin C, creatinine, soluble suppression of tumorigenicity 2, and galectin-3 – to see if they are associated with kidney disease and other adverse outcomes in patients with heart failure.

PI_NAMEs: HEDAYATI, SUSAN  (contact);ROEHM, BETHANY

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: adverse outcome;Aldosterone Antagonists;Biological Markers;biomarker identification;Blood;Blood Tests;Cardiovascular system;Cause of Death;Cessation of life;Chronic Kidney Failure;Clinical;clinical decision-making;clinical practice;cohort;Complex;conventional therapy;Creatinine;Data;data registry;Data Set;Disease Progression;EFRAC;Eligibility Determination;Equation;Evaluation;Event;Functional disorder;Future;Galectin 3;Glomerular Filtration Rate;Goals;hazard;Heart;Heart Arrest;Heart failure;heart failure with reduced ejection fraction;heart function;heart preservation;Heart Transplantation;high risk;Hospitalization;implantation;interest;Kidney;Kidney Diseases;Knowledge;left ventricular assist device;Left Ventricular Hypertrophy;Life;Measurable;Measurement;Measures;Mediating;Modeling;mortality;mortality risk;National Heart, Lung, and Blood Institute;novel;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Population;post gamma-globulins;preservation;Prognostic Marker;prognostication;programs;prospective;Registries;renal damage;Renal function;Risk;Sample Size;Sampling;sarcopenia;Serum;Side;Specimen;standard of care;study population;Testing;Tumorigenicity;ventricular assist device

PROJECT_TITLE: Blood Biomarkers Associated with Adverse Outcomes in Heart Failure