NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: CASPER, COREY  (contact)

PROJECT_TERMS: Antigen Targeting;Antigens;Binding;Biological;biophysical properties;Cells;Clinical;Cloning;Complement 4b;Complex;Data;delivery vehicle;design;DNA;Evaluation;Flow Cytometry;Formulation;Fred Hutchinson Cancer Research Center;Future;Genetic Transcription;Harvest;HIV;immunogenicity;In Vitro;in vivo evaluation;Liquid substance;manufacture;Membrane;Molecular Sieve Chromatography;nanoparticle;nanoparticle delivery;Nanostructures;particle;Phase I Clinical Trials;plasmid DNA;Process;product development;Production;Protocols documentation;Research;research and development;Ribonucleases;RNA;RNA amplification;RNA delivery;RNA replication;RNA vaccine;stability testing;structured lipid;Techniques;Technology;Testing;Transfection;vaccine evaluation;vaccine platform;Vaccine Production;Vaccines;Venezuelan Equine Encephalitis Virus;Western Blotting

PROJECT_TITLE: Scientific Core One


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PI_NAMEs: PANCERA, MARIE  (contact)

PROJECT_TERMS: Antibodies;Antibody Formation;Antibody Response;Antigens;B-Lymphocytes;Binding;Biochemical;Complement 4b;Complex;Cryoelectron Microscopy;Crystallization;Cyclic GMP;design;Electron Microscopy Facility;env Gene Products;env Glycoproteins;Enzyme-Linked Immunosorbent Assay;Epitopes;Germ Lines;Glycoproteins;HIV-1;HIV-1 vaccine;Human;Immunization;In Vitro;interest;Knock-in Mouse;Mammalian Cell;manufacture;Maps;Membrane;Messenger RNA;Methodology;Methods;Monoclonal Antibodies;nanoparticle;neutralizing antibody;Production;protein complex;Reagent;Recombinant Antibody;Recombinant Proteins;Recombinants;Resolution;response;RNA vaccine;Robot;Sarna;Structure;Universities;Vaccines;Validation;Washington;X-Ray Crystallography

PROJECT_TITLE: Scientific Core Two


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative / Public health relevance Novel strategies are needed to prevent or delay the onset of Alzheimer's disease (AD) and AD-related dementias (AD/ADRD). This project aims to study the association between the gut microbiome, an excellent modifiable risk factor, and early markers of AD/ADRD. Understanding this link could help develop microbiome-targeted therapies for AD/ADRD.

PI_NAMEs: FONGANG, BERNARD  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Address;Affect;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Anti-Inflammatory Agents;Applications Grants;Award;Bacteria;bacterial community;bacterial metabolism;Bacteroides;Biochemistry;Bioinformatics;Biology;Blood;Blood - brain barrier anatomy;Brain;brain health;career;Caring;Cause of Death;Central Nervous System;cerebral atrophy;Chronology;cohort;Collaborations;Communication;Data;Dementia;Dependence;Development;Diagnosis;Diet;Disease;drug development;endophenotype;Episodic memory;Escherichia;ethnic difference;Ethnic Origin;Ethnic Population;ethnoracial minority;Etiology;executive function;experience;fecal microbiota;Foundations;Framingham Heart Study;Functional disorder;Funding;Future;Genetic;Goals;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;high risk;Hispanic Populations;Human Microbiome;Individual;Inflammatory;Infrastructure;innovation;insight;interest;Learning;Link;lipidomics;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Neoplasms;Mass Spectrum Analysis;mathematical model;Measures;Memory;Mentored Research Scientist Development Award;Mentors;Metabolic;Metabolism;metabolome;metabolomics;Methods;microbial;microbial community;microbiome;microbiota;microbiota metabolites;microbiota-gut-brain axis;Microvascular Dysfunction;mild cognitive impairment;minority patient;Modeling;modifiable risk;multi-ethnic;Neurocognitive;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neuropsychology;new therapeutic target;Not Hispanic or Latino;novel;novel marker;novel strategies;Nutrient;Obesity;Outcome Measure;Pathogenicity;Pathology;Pharmaceutical Preparations;Physiology;Plasma;Population;population stratification;Populations at Risk;Prevalence;prevent;Prevotella;processing speed;public health relevance;Reporting;Research;response;Risk Factors;risk stratification;Role;sex;Sex Differences;Shigella;Signal Transduction;South Texas;structural biology;Structure;study population;systemic inflammatory response;targeted treatment;Testing;Texas;Therapeutic;Thinking;Time;visual memory;white matter

PROJECT_TITLE: Delineating the role of the gut microbiota and its derived metabolites in the development of dementia in multi-ethnic populations


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Kidney Disease;Neurosciences;Pediatric

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This research proposal is directly focused on improving the lives of children and adolescents with kidney disease. We will characterize the relationship between kidney disease biomarkers, quantitative neuroimaging correlates, and cognitive concerns observed in early pediatric chronic kidney disease (CKD) – prior to need for dialysis or transplant. The proposed research will directly evaluate the impact of CKD progression on cognition and the developing brain in order to identify disease-related risk factors, particularly those that are modifiable, that can be harnessed to mitigate cognitive risk.

PI_NAMEs: HARSHMAN, LYNDSAY ANNE (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Academic achievement;Acidosis;Address;Adolescent;Adult;Age;anatomic imaging;Attention;Awareness;Behavior;Behavior assessment;Biological Markers;Brain;brain abnormalities;brain magnetic resonance imaging;burden of illness;Cerebellar Cortex;Cerebellum;Child;Childhood;Chronic Kidney Failure;Cognition;Cognitive;cognitive performance;cohort;comparison control;congenital anomalies of the kidney;Corpus Callosum;Data;Dentate nucleus;Development;Dialysis procedure;Disease;Disease Progression;dosage;Etiology;executive function;frontal lobe;Glomerular Filtration Rate;Goals;Graduation Rates;gray matter;high school;Hypertension;Image;Impaired cognition;Impairment;improved;Intelligence;Kidney;Kidney Diseases;Laboratories;life span;Link;Magnetic Resonance Imaging;Measures;Metabolism;National Institute of Diabetes and Digestive and Kidney Diseases;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neuroimaging;novel;novel strategies;Outcome;Participant;Patient Care;Patients;pediatric patients;peer;Performance;Pontine structure;Population;Publishing;Quality of life;Regulation;Renal function;Research;Research Proposals;Rest;rho;Risk;Risk Factors;Role;School-Age Population;Severity of illness;Shapes;Signal Transduction;Structure;Testing;Transplantation;Underachievement;Underemployment;Uremia;Urinary tract;white matter

PROJECT_TITLE: Brain anatomical imaging and neurocognition in pediatric kidney disease (BRAIN KID)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: After heart attack the heart loses many muscle cells which leads to the loss of ability to bump blood to the rest of the body. The muscle cells in the heart are not able to regenerate themselves which made it difficult to treat such disease. Here we are developing new transient gene therapy approach to regenerate these muscle cells in the heart and make them able to heal the heart.

PI_NAMEs: MOHAMED, TAMER M A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Adenoviruses;Adult;Adverse effects;Area;Blood;Calcium;Cardiac;Cardiac Myocytes;CDC2 gene;CDK4 gene;Cell Cycle;Cell division;Cell Proliferation;cell type;Cells;clinical application;Clinical Trials;Contracts;cyclin B1;Cyclin D1;Cytokinesis;Data;Daughter;Disease;dosage;efficacy evaluation;efficacy testing;Electrophysiology (science);Event;Family suidae;first-in-human;Gene Expression Profile;gene therapy;Generations;healing;Heart;Heart failure;heart function;Hip region structure;Human;human old age (65+);improved;In Situ;In Vitro;in vivo;Infarction;Ischemia;Kidney;Lentivirus;Liver;Mediating;Methods;Modeling;mosaic analysis;mouse model;multicatalytic endopeptidase complex;Mus;Muscle Cells;muscle regeneration;Myocardial Infarction;Natural regeneration;Neurons;novel;novel strategies;Oncogenic;Organ;overexpression;Pancreas;Parents;Persons;porcine model;postmitotic;preclinical efficacy;Proliferating;Proliferation Marker;promoter;Property;protein degradation;Rattus;Recording of previous events;Reperfusion Therapy;Reporter;Rest;Rodent;Safety;safety study;Slice;Specificity;System;Technology;Testing;Therapeutic;Time;Tissues;tool;transcriptome sequencing;Transgenic Organisms;translational potential;Treatment Failure;Troponin T;tumorigenic

PROJECT_TITLE: Induction of Cardiomyocyte Proliferation via Transient Expression of Cell Cycle Factors as a Promising Therapy for Heart Failure

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


PI_NAMEs: STAMATATOS, LEONIDAS  (contact)

PROJECT_TERMS: Acceleration;Address;Adjuvant;Affinity;Antibodies;Antibody Response;Antigens;Autologous;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Bypass;Clinical Trials;Complement 4b;design;env Gene Products;Germ Lines;Goals;Grant;HIV-1;HIV-1 vaccine;Immunization;Immunization Schedule;improved;Light;manufacture;Membrane;Methodology;Modality;Monoclonal Antibodies;Mutate;nanoparticle;neutralizing antibody;Predisposition;prevent;Process;Production;Protein Secretion;Proteins;Recombinant Proteins;Recombinants;Reporting;research clinical testing;response;RNA;RNA amplification;RNA vaccine;self assembly;Somatic Mutation;Specificity;Vaccination;vaccination strategy;vaccine delivery;vaccine platform;Virus

PROJECT_TITLE: Scientific Project One


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: Project Narrative  The inexorable increase of cephalosporin resistance in N. gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, has severely limited treatment options and threatens a public health crisis. This application proposes to elucidate the molecular mechanisms of cephalosporin resistance conferred by mutations in N. gonorrhoeae penicillin-binding protein 2, with the hypothesis that mutations act by restricting protein dynamics. The long-term goal is to translate this information toward the design of new antimicrobials that overcome such mechanisms.

PI_NAMEs: DAVIES, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Active Sites;Acylation;Alleles;Antibiotic Resistance;Antibiotics;antimicrobial;Arthritis;Behavior;beta-Lactams;Binding;Biological Process;Cefixime;Ceftriaxone;Cell Wall;Cephalosporin Resistance;Cephalosporins;Complex;Contracts;design;Deuterium;Development;experimental study;Female;fitness;Goals;Gonorrhea;Growth;HIV;Hydrogen;Impairment;Individual;Infection;Infertility;Investigation;loss of function;Molecular;Molecular Conformation;molecular dynamics;Morphology;mosaic;Movement;mutant;Mutate;Mutation;Neisseria gonorrhoeae;Organism;Pelvic Inflammatory Disease;Penicillin Binding Protein 2;Peptides;Peptidoglycan;Peptidyltransferase;Predisposition;preservation;Process;Protein Dynamics;Proteins;Public Health;Reaction;Relaxation;Resistance;resistance mechanism;resistance mutation;resistant strain;Resolution;Risk;Role;Serine;sex;Sexually Transmitted Agents;Sexually Transmitted Diseases;Side;Structure;Translating;transmission process;Variant;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanism of cephalosporin resistance of N. gonorrhoeae conferred by mutated PBP2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-A(06)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Immunotherapy;Rheumatoid Arthritis

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Immune suppressive drugs have greatly improved the management of inflammatory joint disorders in children and adults, but increase the risk of serious infections and cancer. In contrast to generalized immunosuppression, this project aims to validate an immune modulating agent for expanding and restoring disease-protective immune cells called Treg to spare joints from damage. If successful, our approach has the potential to greatly improve disease control without further suppressing protective immune responses in patients.

PI_NAMEs: SHAH, NISARG J. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acids;Address;Adjuvant;Adult;Affect;anti-arthritic drug;Antiinflammatory Effect;Applications Grants;Arthritis;arthropathies;Autoantigens;autoimmune arthritis;Autoimmune Diseases;Autoimmunity;autoreactive T cell;autoreactivity;Biodegradation;Biodistribution;Bolus Infusion;CD4 Positive T Lymphocytes;Cells;Child;Chronic Childhood Arthritis;Circulation;Clinical;Disease;Disease remission;Disease-Modifying Second-Line Drugs;disorder control;Drug Delivery Systems;Effectiveness;effectiveness evaluation;Glycolates;Goals;Histopathology;Human;IL17 gene;Immune;immune function;immune modulating agents;Immune response;Immune system;Immunity;Immunize;Immunodeficient Mouse;immunoregulation;Immunosuppression;Impairment;improved;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;Injections;insight;Intra-Articular Injections;joint inflammation;joint injury;Joints;Knowledge;loss of function;Malignant Neoplasms;Maps;Mediating;Methods;Methotrexate;Modeling;Modification;mouse model;Mus;novel therapeutic intervention;Orphan;Ovalbumin;particle;Pathogenicity;Patients;Pharmaceutical Preparations;Phenotype;Polymers;prevent;Proteins;Radiolabeled;receptor;recruit;Regulatory T-Lymphocyte;Research;Rheumatoid Arthritis;Risk;Safety;Severity of illness;Systemic disease;T cell response;Technology;Testing;Therapeutic;Tissues;Toxic effect;Tretinoin

PROJECT_TITLE: Intra-Articular Drug Delivery Modulating Immune Cells in Inflammatory Joint Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(82)S]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative We and others have demonstrated a causal role for an upregulated Claudin-1 expression in promoting colorectal cancer (CRC) metastasis. Here we propose to develop a novel inhibitor for preclinical testing and determine the specificity, efficacy and molecular mechanism for inhibiting CRC.

PI_NAMEs: DHAWAN, PUNITA  (contact);HOPKINS, COREY R.

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: analog;Anoikis;anticancer activity;Applications Grants;Binding;Biochemical;Biology;Biometry;cancer cell;cancer therapy;Cell Line;Cells;Cessation of life;Chemicals;Chemoresistance;claudin-1 protein;Clinical Management;Clinical Research;cohort;colon cancer metastasis;colon cancer patients;colon cancer progression;Colon Carcinoma;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;colorectal cancer treatment;Colorectal Surgery;Complex;Crystallography;Data;design;Diabetic Nephropathy;Diagnosis;Diagnostic Neoplasm Staging;Disease Management;Disparate;Disseminated Malignant Neoplasm;Distant;Drug Kinetics;efficacy evaluation;Ephrins;Epitopes;Fluorouracil;Genetic;Genetically Engineered Mouse;Goals;gut homeostasis;Hepatitis C;improved;in silico;In Vitro;in vitro Model;in vivo evaluation;inhibitor;Invaded;Investigation;Knowledge;Laboratories;Libraries;Liver;Lung;Malignant Neoplasms;Mediating;metastatic colorectal;Microsomes;Modeling;Molecular;mortality;mouse model;Mus;mutant;Neoplasm Metastasis;Nonmetastatic;novel;novel therapeutics;Oncogenic;Organ;Organoids;Outcome;overexpression;Pathology;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmacologic Substance;Phenotype;Play;preclinical study;Preclinical Testing;Property;Protein Isoforms;Proteins;Proto-Oncogenes;Qualifying;receptor;Reporting;Resistance;Risk;Role;Sampling;Scientist;side effect;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;Specificity;src-Family Kinases;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;tool;Toxic effect;translational potential;tumor;tumor growth;tumor xenograft;v-src Oncogenes

PROJECT_TITLE: Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Targeted cancer therapies have the exciting potential to selectively kill malignant cells while sparing healthy tissues, as evidenced by their often remarkable upfront activity in patients. However, in nearly all patients, a subset of residual cancer cells survive therapy and later emerge to give rise to resistant disease that is very difficult to treat. In this proposal, we build on our recent discovery of unique biological processes related to cell death regulation and DNA repair that are activated in residual cancer cells, proposing mechanistic studies that will significantly expand our understanding of residual tumor biology while directly nominating therapeutic strategies to eliminate this critical tumor cell population.

PI_NAMEs: WOOD, KRIS C. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acute Myelocytic Leukemia;Animal Model;Area;ataxia telangiectasia mutated protein;ATM activation;Automobile Driving;Biological;Biological Process;Biology;BRAF gene;cancer cell;Cancer Model;Cancer Patient;cancer subtypes;cancer type;CASP3 gene;CASP7 gene;Caspase;caspase-activated deoxyribonuclease;Cell Death;Cell model;Cell Survival;Cells;Clinical;Combined Modality Therapy;Credentialing;Dependence;Disease Resistance;DNA Damage;DNA Double Strand Break;DNA Repair;DNA-dependent protein kinase;Double Strand Break Repair;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;Exhibits;FDA approved;FGFR2 gene;fitness;Foundations;gene-editing approach;Genetically Engineered Mouse;Genomics;Global Change;inhibitor;inhibitor therapy;interest;Link;loss of function mutation;Lung Adenocarcinoma;Lung Neoplasms;Melanoma;Molecular;mutant;neoplastic cell;Non-Small-Cell Lung Carcinoma;Oncogenes;Outcome;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Phosphotransferases;PIK3CA gene;Population;Progression-Free Survivals;Progressive Disease;Proliferating;Proteomics;Regulation;repaired;Residual Cancers;Residual Neoplasm;Residual state;response;restraint;Sampling;Signal Transduction;Specimen;targeted cancer therapy;targeted treatment;Therapeutic;therapeutic target;Tissues;translational potential;treatment response;tumor;Tumor Biology;Up-Regulation;Work

PROJECT_TITLE: Mechanism-based targeting of unique survival signaling in residual tumors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative  Amongst the neuronal populations implicated in sleep-wake control, the ventrolateral preoptic (VLPO) nucleus has emerged as a key sleep-promoting center. This project seeks to define the long-range and local cellular and circuit bases by which arousal and sleep-promoting afferent inputs to the VLPO contribute to behavioral and electrocortical sleep and arousal. Successful completion of the proposed studies may contribute to the development of new therapeutic and interventional strategies for a wide range of sleep and arousal disorders, including insomnia, hypersomnia and aging-related sleep disturbances.

PI_NAMEs: ARRIGONI, ELDA  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Affect;Afferent Pathways;aging related;Anatomy;Arousal;base;Behavior;Behavioral;Behavioral Model;Brain;brain circuitry;Brain Stem;Cells;cholinergic;cholinergic neuron;combinatorial;Data;Development;Disease;Disinhibition;drug development;Enterobacteria phage P1 Cre recombinase;Exhibits;Fiber;FLP recombinase;Galanin;Hypersomnias;Hypothalamic structure;In Vitro;in vivo;Influentials;insight;Interneurons;Intervention;Knowledge;Lateral;Lesion;Maps;Mediating;Methodology;Modeling;monoamine;Nervous System Disorder;neurochemistry;neuronal circuitry;Neurons;novel;novel therapeutics;Optics;optogenetics;Pathway interactions;Patients;Photometry;Population;postsynaptic neurons;preoptic nucleus;presynaptic;Process;Prosencephalon;Publishing;Regulation;Research;response;Role;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Sleeplessness;Slice;Source;Specificity;Synapses;Synaptic Potentials;Testing;Time;transmission process;Wakefulness;Work

PROJECT_TITLE: Neuronal Circuit Controlling Sleep-Promoting Ventrolateral Preoptic Neurons

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is one of the most common pediatric autoimmune diseases caused by complex interactions between genetic susceptibility loci and environmental factors. Despite identifying genetic regions associated with an increased T1D risk, many lack a testable gene or pathway to explain the risk for disease, and even validated variants have not been tested for cell type effects in the immune system. This proposal focuses on a promising gene associated with T1D and islet autoimmunity to understand the cell types responsible for diabetes progression when this genetic alteration is present.

PI_NAMEs: ALLENSPACH, ERIC J (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Adoptive Transfer;Affect;Affinity;Alleles;Animal Model;Animals;Antibodies;Antigen Presentation;Antigen Receptors;Antigens;Area;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;B-Lymphocytes;Biological;career;career development;CD8-Positive T-Lymphocytes;Cell Count;Cell Differentiation process;Cell Survival;cell type;Cells;Cellular biology;cellular targeting;Characteristics;Childhood;Clinical;Coculture Techniques;Code;comparison control;Complex;Coupled;CTLA4 gene;Cues;cytokine;Cytokine Receptors;Cytokine Signaling;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Progression;disorder risk;Effector Cell;Environmental Risk Factor;European;exhaust;exhaustion;experience;Flow Cytometry;Funding;Future;Gene Frequency;Genes;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic signature;Genetic study;Genetic Transcription;Genotype;Goals;Grant;Hour;Human;IL2RA gene;IL7 gene;Immune;Immune system;Immunology;Immunophenotyping;In Vitro;in vitro testing;in vivo;Incidence;Insulin-Dependent Diabetes Mellitus;insulitis;interest;Interferon Type II;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-15;Interleukin-2;interleukin-21;islet;islet autoimmunity;K-Series Research Career Programs;Link;Lymphopoiesis;Measures;Memory;Mentors;Mentorship;Modeling;Molecular;Monitor;monocyte;mouse model;Mus;Mutation;Myelogenous;Myelopoiesis;National Institute of Diabetes and Digestive and Kidney Diseases;Pancreas;Pathogenicity;Pathway interactions;pediatric department;peptide vaccination;Peptides;Peripheral;Phenotype;Physicians;Principal Investigator;professor;programs;Proliferating;Proteins;PTPN22 gene;Publications;rare variant;receptor;Receptor Signaling;Refractory;Reporter;Reporting;Research;response;Rheumatology;Risk;risk variant;Role;Sampling;Scientist;Shapes;Signal Transduction;stem cells;Structure of beta Cell of islet;Surface;Susceptibility Gene;T cell response;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;thymocyte;Tissues;transcription factor;Transgenic Model;translational approach;United States National Institutes of Health;Universities;Variant;Washington;Western Blotting;Work

PROJECT_TITLE: The role of SH2B3 in regulating CD8 T cells in Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Cell size is an important cellular property that is controlled by tying division to growth. We aim to determine the molecular mechanism cells use to measure their size so that growth can trigger proliferation in both budding yeast and mammalian cells.

PI_NAMEs: SKOTHEIM, JAN M (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: cancer therapy;Cell Cycle;Cell division;cell growth;Cell Physiology;Cell Size;cell type;Cells;Cellular Morphology;Cyclin-Dependent Kinases;Development;Disease;Genetic Transcription;genome editing;genome-wide;Goals;Growth;Human;Individual;Laboratories;Link;Mammalian Cell;mammalian genome;Measures;Molecular;novel;Proliferating;Property;Proteins;Resolution;Saccharomycetales;Technology;Time;Work;Yeasts

PROJECT_TITLE: Determining how cell growth triggers cell division

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Sleep Research;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Obstructive sleep apnea (OSA) is a growing and serious worldwide health problem with significant health and socioeconomic consequences. Poor adherence to continuous positive airway pressure (CPAP), the primary treatment option for OSA, is associated with increased morbidity, mortality, and health care costs, and has been a major obstacle in the effective management of OSA. This project addresses the critical need to improve CPAP adherence by refining and testing an innovative couple-focused mobile health intervention.

PI_NAMEs: YE, LICHUAN  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Adherence;Adopted;Affect;Age;Caring;Characteristics;Clinic;Clinical Trials;Continuous Positive Airway Pressure;Control Groups;coping;Couples;Data;demographics;Development;Diagnosis;Disease;Drowsiness;effective therapy;effectiveness evaluation;efficacy outcomes;Emotional;Evaluation;experience;Exposure to;Family;field study;Frequencies;Gender;Goals;group intervention;handheld mobile device;Health;Health Benefit;Health Care Costs;health economics;Health Professional;improved;Individual;innovation;Intervention;Interview;Life;Link;Maintenance;Measures;mHealth;mhealth interventions;Modeling;Morbidity - disease rate;mortality;Newly Diagnosed;Notification;Obstructive Sleep Apnea;Patients;Periodicals;pilot test;Play;Preparation;Problem Solving;Process;promoter;prototype;Qualitative Methods;Quality of life;Race;Randomized;Role;secondary outcome;Secure;Self Efficacy;Self Management;Sleep;Sleep disturbances;sleep quality;Snoring;social;socioeconomics;Standardization;Subgroup;success;Technology;Testing;tool;treatment adherence;treatment optimization;Treatment outcome;Update;Work

PROJECT_TITLE: OurSleepKit: A Couple-focused mHealth Tool to Support Adherence to CPAP Treatment

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: This proposal will advance our studies of the previous HL131872 program period by examining the role of serotonin receptor signaling and downstream events in the pathogenesis of degenerative mitral regurgitation. The proposed experiments will investigate serotonin related platelet activity in human and canine blood, and relate this mitral valve disease. The program will also study serotonin mechanisms in human mitral valve specimens collected under approved protocols.

PI_NAMEs: FERRARI, GIOVANNI ;LEVY, ROBERT J (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Adult;Affect;Agonist;Alpha Granule;Anabolism;antagonist;anti-depressive agents;aortic valve;Area;Aspirin;Blood;Blood Platelets;BMP4;Bone Marrow;Bone Marrow Ablation;Bone Marrow Transplantation;Canis familiaris;Carcinoid Tumor;CD34 gene;Cells;Childhood;Chronic;Clinical Pathology;coronary fibrosis;Cytoplasmic Granules;Diet;Disease;Disease Progression;Down-Regulation;Endothelial Cells;Endothelium;Event;Experimental Designs;experimental study;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Feasibility Studies;Flow Cytometry;Functional disorder;Gene Expression Profile;Heart Valve Diseases;Heart Valves;Homeostasis;Homing;HTR2A gene;Human;human old age (65+);human subject;In Vitro;inhibitor;interstitial cell;Maintenance;Measurement;Mediating;Mesenchymal;migration;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Multivariate Analysis;Mus;Neurotransmitters;Operative Surgical Procedures;Pathogenesis;Pathologic;Patients;personalized approach;Pharmaceutical Preparations;Phenotype;Platelet Activation;Population;Preventive treatment;Production;progenitor;programs;Proteomics;Protocols documentation;Quantitative Reverse Transcriptase PCR;receptor;Receptor Signaling;repaired;Research;restoration;reuptake;Role;Selective Serotonin Reuptake Inhibitor;Serotonin;serotonin receptor;serotonin transporter;Signal Transduction;single cell sequencing;Specimen;stem cells;Therapeutic;therapeutic target;Thick;Tissues;transcriptome;transcriptomics;Transforming Growth Factor beta;Tryptophan;Tryptophan 5-monooxygenase;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Serotonin Signaling in Mitral Valve Homeostasis, Maintenance and Restoration


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and to the NIAAA's mission because it employs novel approaches to investigate neuroimmune factors expressed by astrocytes (understudied brain cells that are essential for the proper functioning of the brain) in an animal model of alcohol dependence. The proposed studies will provide insights on how alterations in astrocytes result in increased inflammation leading to increased alcohol drinking. The aforementioned insights, obtained using and clinical genetically engineered animal models emerging “-omic” approaches in a cell-type specific manner (astrocytes), will provide new mechanistic and understanding of the impact of astrocytes in alcohol dependence andwill lead to therapeutic interventions that are not only specific for a given molecular target, but also for a given cellular target and, for this reason, safer.

PI_NAMEs: GUIZZETTI, MARINA  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Affect;Affinity Chromatography;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Alteplase;Amygdaloid structure;Animal Model;Area;Astrocytes;Attenuated;Automobile Driving;Biological Process;Brain;brain cell;Brain region;brain remodeling;Cell Nucleus;Cell Separation;cell type;cellular targeting;Chronic;Chronic Disease;Clinical;Data;Development;Disease;Down-Regulation;drinking;Ethanol;Extracellular Matrix;Female;Fluorescence;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;glial activation;Heterogeneity;immune activation;Immune response;Immunohistochemistry;Inflammation;insight;Intervention;knock-down;Lead;LoxP-flanked allele;male;Methods;Mission;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Neuroimmune;neuroinflammation;novel strategies;Nuclear;Nuclear RNA;Pathway Analysis;Phenotype;Plasminogen Activator;PLAT gene;Prefrontal Cortex;Procedures;promoter;Protein Biosynthesis;protein expression;Proteins;Proxy;Public Health;Research;response;Ribosomal Proteins;Ribosomes;RNA;sex;Sorting;Specificity;Synapses;Technology;Therapeutic;Therapeutic Intervention;transcriptome;transcriptome sequencing;Translating;Translations;translatome;Western Blotting

PROJECT_TITLE: 6/11 Astrocyte-specific changes and interventions in alcohol dependence


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

PHR: PROJECT NARRATIVE The probability of Mendelian inheritance currently limits the utility of rodents to understand complex genetic processes in embryonic development and disease and to effectively develop drugs and therapeutic approaches that translate well to humans. Such limitations could be overcome by CRISPR/Cas9-mediated gene conversion to increase the probability an animal will inherit a combination of desired alleles, which would reduce the cost, time, and number of animals required to understand and treat complex genetic diseases.

PI_NAMEs: COOPER, KIMBERLY LYNN (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Alleles;Alzheimer's Disease;Animal Model;Animals;Bacterial Artificial Chromosomes;Biological;Biological Process;Biomedical Research;Cells;Chromosomes;Clinical Data;Clinical Trials;Complex;Complex Genetic Trait;cost;CRISPR/Cas technology;Data;design;Development;Diabetes Mellitus;Disease;egg;Embryonic Development;Engineering;Ensure;Event;Female;Frequencies;Future;future implementation;Gene Conversion;Genes;Genetic;Genetic Diseases;genetic information;Genetic Processes;genomic locus;Genotype;Germ Lines;Goals;Guide RNA;Health;Heart Diseases;Heterozygote;Human;Human Development;human disease;Immunity;improved;Individual;Inherited;insight;Knowledge;Laboratories;Laboratory mice;Laboratory Rat;Learning;Link;Litter Size;loss of function;male;mathematical model;Mediating;Meiosis;Meiotic Prophase I;Metabolism;Modeling;Monophenol Monooxygenase;Mus;next generation;offspring;Oocytes;Outcomes Research;permissiveness;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;predictive modeling;Probability;Rattus;repaired;Research;Rodent;sex;sperm cell;Spermatocytes;Technology;technology development;Testing;Therapeutic;Time;tool;Transgenes;Transgenic Organisms;Translating;transmission process;Work

PROJECT_TITLE: Development of approaches to apply CRISPR/Cas9-mediated gene conversion to model complex genetic traits in mice

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Chronic kidney disease is characterized by damage to kidney cells, accumulation of immune cells such as macrophages, and development of kidney fibrosis. We propose to study how PU.1 signaling pathway regulates macrophage activation and development of chronic kidney disease. Results from our study could provide novel insights into macrophage activation and development of chronic kidney disease and could lead to novel therapeutic strategies for chronic kidney disease.

PI_NAMEs: WANG, YANLIN  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: American;CASP1 gene;Cells;ChIP-seq;Chronic;Chronic Kidney Failure;Development;Disease;Experimental Models;Family;Fibrosis;Genetic;Human;IL18 gene;Immune;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;insight;Kidney;kidney cell;Kidney Diseases;kidney fibrosis;knock-down;Knock-out;Liquid Chromatography;Macrophage;Macrophage Activation;marenostrin;Mediating;Modeling;Molecular;Myelogenous;Myeloid Cells;nephrogenesis;novel;novel therapeutic intervention;overexpression;Pathway interactions;Peptide Initiation Factors;pharmacologic;Pre-Clinical Model;prevent;Production;Proteomics;Public Health;Reaction;receptor;Regulation;renal damage;response;Role;Signal Pathway;tandem mass spectrometry;Testing;Therapeutic;treatment strategy

PROJECT_TITLE: Novel mechanisms of kidney inflammation and fibrosis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Neurosciences;Substance Misuse

PHR: Project Narrative Apremilast, a phosphodiesterase type 4 inhibitor and our most promising clinical target for reducing harmful alcohol drinking, has been shown to increase levels of the anti-inflammatory protein, interleukin 10, in the periphery. We investigate how anti-inflammatory signaling in the brain regulates binge-like drinking in mice that have been selectively bred to drink to intoxication. An overarching goal of this proposal is to identify and target anti-inflammatory processes in the brain to reduce drinking and restore alcohol-induced changes in anti- and pro-inflammatory signaling in the brain.

PI_NAMEs: OZBURN, ANGELA RENEE (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Acids;Alcohol consumption;alcohol use disorder;Alcohols;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Award;Behavior;Behavioral;Binding;binge drinking;Brain;Brain region;Breeding;Cells;ChIP-seq;Chronic;Clinical;Collaborations;Complement;cytokine;Darkness;drinking;Drug Screening;Equilibrium;Ethanol;experience;experimental study;Gene Expression;gene expression database;Gene Expression Profile;gene network;Genes;Genetic;Genetic Risk;Genotype;Glutamates;Goals;Heavy Drinking;Human;Immune;Immune signaling;Immune Targeting;Inflammatory;Informatics;inhibitor;Interleukin-10;interleukin-10 receptor;Intoxication;JAK1 gene;Measures;Microglia;Molecular;Molecular Profiling;Mus;Neuroimmune;neuronal excitability;Neurons;Nucleus Accumbens;overexpression;Pathway interactions;Pergolide;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;phosphoric diester hydrolase;Process;Proteins;Protocols documentation;Recording of previous events;Regulation;Research Personnel;Resources;Signal Pathway;Signal Transduction;STAT3 gene;Testing;transcriptome sequencing;transmission process

PROJECT_TITLE: 8/11 Targeting Anti-inflammatory Gene Expression in Binge-like Drinking


NIH_SPENDING_CATS: Genetics;Pediatric;Rehabilitation

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Scoliosis is one of the most common pediatric musculoskeletal disorders, causing disfigurement, psychosocial distress, and is associated with increased back and neurological pain later in life. The causes of these disorders of the spine are likely due to a variety of factors, yet little is known about the genetic factors and signaling pathways involved. This proposal will gain mechanistic insight into the regulation of spine development and homeostasis of important spine tissues through analysis of two signaling pathways, implicated by our characterization of several independent genetic animal models of scoliosis.

PI_NAMEs: GRAY, RYAN SCOTT (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Abate;Adhesions;Adolescent;Adult;Agreement;Alleles;Animal Genetics;Animal Model;Back;Biogenesis;Biological Process;Biomechanics;Cartilage;cartilage development;Cell Physiology;Cells;Chest;Child;Childhood;Collection;Complement;Coupled;Cyclic AMP;Cyclic AMP-Responsive DNA-Binding Protein;Data;Defect;Dense Connective Tissue;Development;Distress;Elements;Engineering;Environment;experimental study;Fibrocartilages;Funding;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;Genetic Processes;Genetic Screening;Genetic study;Goals;GTP-Binding Proteins;Heterogeneity;Homeostasis;Human;Human Genetics;Idiopathic scoliosis;INPPL1 gene;insight;intercalation;Intervertebral disc structure;Investigation;Knockout Mice;Knowledge;Life;Link;Modeling;Molecular;Molecular Genetics;Morphogenesis;Movement;Mus;Musculoskeletal;Musculoskeletal Diseases;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Natural History;Neurologic;notochord;novel;Nucleotides;Pain;Pathogenesis;Pathway interactions;Pattern;Perinatal;Phenotype;Phosphoric Monoester Hydrolases;Predisposition;programs;Property;protein activation;psychosocial;Publishing;Purinoceptor;Receptor Gene;Receptor Signaling;Regulation;Research;Role;scoliosis;screening;Severities;Signal Pathway;Signal Transduction;Signaling Protein;skeletal;skeletal dysplasia;Spinal Cord;Spinal Curvatures;Spinal Diseases;Structural defect;Susceptibility Gene;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Activation Domain;tripolyphosphate;Variant;vertebra body;Vertebral column;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Investigations of the molecular genetics and pathogenesis of scoliosis.

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Aging;Diabetes;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Mammalian aging is associated with the expansion and accumulation of fat tissue which hinders metabolic function and increases the incidence of premature death due to type 2 diabetes and cardiovascular disease. Cold temperatures can stimulate progenitor cells to form thermogenic beige fat which can boost metabolism to counteract uncontrolled fat accumulation and metabolic disease; however, the potential to create beige fat cells declines with age. Our application seeks to decipher how aging disrupts beige fat development with the goal to revive beige fat to promote healthy fat tissue and fuel metabolic fitness in aging humans.

PI_NAMEs: BERRY, DANIEL CARL (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Ablation;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Age;age related;age related changes;age related decline;aged;Aging;aging process;Agreement;Automobile Driving;Biochemical;Biogenesis;Blood Glucose;Blood Vessels;Body fat;Cardiovascular Diseases;Cell Aging;Cell Communication;Cells;Cessation of life;Clinical;clinical efficacy;cold temperature;combat;Communication;Consumption;desensitization;Deterioration;Development;extend lifespan;Failure;Fatty acid glycerol esters;Fostering;Functional disorder;Generations;Genetic;Genetic Models;Genetic Transcription;Glucose;Goals;Health;healthspan;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Immune;Immunologics;improved;Incidence;Interleukins;juvenile animal;Link;Longevity;Lymphoid Cell;Mammals;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic fitness;Metabolism;Methods;Modeling;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel therapeutics;obese patients;Obesity;Obesity Epidemic;old mice;Older Population;Output;Pathway interactions;pharmacologic;Phenotype;Physiological;Platelet-Derived Growth Factor beta Receptor;Population;premature;preservation;prevent;progenitor;Ramp;recruit;Rejuvenation;Research;response;Role;senescence;Signal Transduction;Signaling Molecule;Source;stem cell aging;stem cell function;stem cells;Testing;Therapeutic;thermal stress;Tissues;transcriptomics;Type 2 diabetic;Up-Regulation;young adult

PROJECT_TITLE: Deciphering age-dependent beige adipocyte failure

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE As part of the Integrative Neuroscience Initiative on Alcoholism (INIA) Consortium, this project will focus on epigenetic-related mechanisms involving the neuroimmune system that are affected by excessive ethanol exposure. In collaboration with other INIA investigators, we will use cutting-edge approaches such gene mutagenesis (i.e., CRISPR) and high-throughput sequencing to determine novel molecular mechanisms associated with the development of Alcohol Use Disorder (AUD).

PI_NAMEs: FARRIS, SEAN P (contact);HOMANICS, GREGG E.

PROJECT_TERMS: Affect;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol response;alcohol testing;alcohol use disorder;Alcoholism;Animal Behavior;Animals;behavior test;behavioral phenotyping;behavioral response;Biological Process;brain cell;Breeding;Candidate Disease Gene;Cell Nucleus;Cell Physiology;Cells;Central Nervous System;Chromatin;chromosome conformation capture;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Collection;Consumption;Development;Disease;Distant;Drug Addiction;Enhancers;Epigenetic Process;epigenetic regulation;Ethanol;experimental study;gene editing technology;Gene Expression;Gene Expression Regulation;Genes;genetic approach;Genetic Engineering;Genome;genome editing;genome-wide;Genomic approach;genomic locus;Genomic Segment;Genomics;Goals;Hi-C;High-Throughput Nucleotide Sequencing;High-Throughput RNA Sequencing;Human;Immune system;Immunity;In Vitro;in vitro Model;in vivo;Individual;inducible Cre;Knock-out;Knockout Mice;LoxP-flanked allele;Maps;Mediating;Microglia;Molecular;Molecular Target;mouse Cre recombinase;Mus;Mutagenesis;mutant;Mutant Strains Mice;Neuroimmune;Neuroimmune system;neuroinflammation;neuropsychiatric disorder;Neurosciences;novel;Nucleotides;Organism;Pathway interactions;Peripheral;preference;promoter;Proteins;Regulatory Element;Research;Research Personnel;Research Project Grants;response;RNA;Role;Signal Pathway;Signal Transduction;Space Perception;Structure;System;Tamoxifen;Techniques;Testing;Training;Transcript;transcriptome;Translating;Untranslated RNA;Validation

PROJECT_TITLE: 3/11 Epigenetic Regulation of Neuroimmune Pathways


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: There is an urgent need to develop interventions that will delay functional disability and improve the quality of life of our growing aging population. This work is expected to lead to a scalable compensation and lifestyle intervention to improve well-being and delay disability in individuals at risk for Alzheimer's disease and other disorders. This research is relevant to public health and NIH's mission as the results are expected to have an important positive impact on caregiver burden, health care costs and the functional independence of our aging population.

PI_NAMEs: SCHMITTER-EDGECOMBE, MAUREEN ;TOMASZEWSKI-FARIAS, SARAH E (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Activities of Daily Living;Adherence;Adoption;Aftercare;Age;aging population;Alzheimer's Disease;Alzheimer's disease risk;Behavior;Behavior monitoring;Behavior Therapy;Behavioral;Brain;brain health;Calendar;Caregiver Burden;Characteristics;Cognition;Cognitive;Collection;Compensation;Competence;Control Groups;cost;daily functioning;Data;Data Collection;dementia risk;design;Development;digital;digital applications;digital data;digital tool;disability;Disease;Education;Educational Intervention;Educational Materials;efficacy evaluation;Encapsulated;Ethnic Origin;ethnoracial;evidence base;executive function;Exercise;Exhibits;Feedback;follow-up;functional disability;functional improvement;functional independence;Future;Goals;Health;Health behavior;Health Care Costs;health care delivery;health literacy;Health Status;healthy aging;healthy lifestyle;Impaired cognition;improved;Individual;innovation;insight;instrumental activity of daily living;Interdisciplinary Study;Intervention;Interview;Knowledge;Life Style;Life Style Modification;lifestyle intervention;Machine Learning;machine learning algorithm;Maintenance;Measures;Medical;Memory;Methods;mild cognitive impairment;Mission;modifiable risk;Monitor;Motivation;Neuronal Plasticity;Neuropsychology;novel;older adult;Outcome;outcome prediction;Participant;Pattern;Personal Satisfaction;Persons;Physical activity;Physical Function;Pilot Projects;Population Heterogeneity;Populations at Risk;post intervention;Prediction of Response to Therapy;Prevalence;prevent;preventive intervention;primary outcome;promote resilience;Public Health;Quality of life;Race;Randomized;Randomized, Controlled Trials;Research;Research Design;Risk Reduction;secondary outcome;Self Determination;sex;Socioeconomic Status;stress management;Structure;success;support tools;Symptoms;System;Tablets;Technology;technology development;Testing;theories;therapy development;Time;tool;Training;Translations;treatment adherence;Treatment Effectiveness;Treatment Efficacy;Treatment outcome;treatment responders;United States National Institutes of Health;uptake;user-friendly;Work

PROJECT_TITLE: Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  The progressive loss of hair cells, the sensory receptors within the cochlea and vestibular system, results in irreversible deterioration of the auditory and vestibular functions. Our work has established that Hippo signaling serves as a major repressive mechanism preventing supporting cell-mediated hair cell regeneration in the mammalian inner ear. The pathway, therefore, represents a new therapeutic target for induction of hair cell regeneration, and the proposed work is directly relevant to the NIH’s mission to uncover new knowledge that will lead to better health for everyone.

PI_NAMEs: GNEDEVA, KSENIA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Address;Adult;Auditory;Auditory Brainstem Responses;Basic Science;Binding;Cell Cycle;Cell Cycle Progression;Cell division;Cell Maturation;Cell Proliferation;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Cochlea;Cyclin-Dependent Kinase Inhibitor;cyclin-dependent kinase inhibitor 1B;Data;Deterioration;Diphtheria Toxin;drug withdrawal;Dyes;Ear;Embryo;Enzymes;Epigenetic Process;Equilibrium;Evoked Potentials;experimental study;Fishes;Gene Activation;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Hair;hair cell regeneration;Hair Cells;Health;Hearing;Immunohistochemistry;In Vitro;in vitro regeneration;in vivo;in vivo regeneration;inhibitor;Injections;Injury;innovation;Knowledge;Label;Labyrinth;Link;Mammals;Measurement;Measures;Mediating;Methods;Mission;Mitotic;Molecular;Molecular Analysis;Monitor;multiple omics;Mus;Natural regeneration;Neonatal;new therapeutic target;Organ;Organ of Corti;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Population;postmitotic;postnatal;prevent;Process;progenitor;Proliferating;Receptor Gene;Recovery;Recovery of Function;Regimen;Repression;Research;Residual state;Resistance;restoration;RNA;Scanning Electron Microscopy;Sensory;Sensory Hair;Sensory Receptors;Signal Transduction;small molecule inhibitor;stem cells;Structure of posterior semicircular canal;Supporting Cell;synergism;Techniques;Testing;Therapeutic;Time;tool;Transcription Coactivator;United States National Institutes of Health;uptake;Utricle structure;Vertebrates;Vestibular function;Vestibular Hair Cells;vestibular system;Work;XCL1 gene

PROJECT_TITLE: Hippo-mediated control of growth and regeneration in the inner ear sensory organs

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cystic Fibrosis;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: This proposal describes a new metabolic imaging technology to image infection, using a mirror-image amino acid that is an essential component of the bacterial cell wall. A new radiotracer developed for positron emission tomography will be used to identify bacteria common in cystic fibrosis patients with the goal of better understanding and treating this disease.

PI_NAMEs: ENGEL, JOANNE N.;OHLIGER, MICHAEL ;WILSON, DAVID M (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acute;acute infection;Address;Adult;Alanine;Amino Acids;analog;Antibiotic Therapy;Antibiotics;Automation;Bacteria;Bacterial Antibiotic Resistance;Bronchoalveolar Lavage;Bronchoscopy;Cell Nucleus;Cell Wall;Cells;Chronic;chronic infection;Clinical;clinical application;clinical translation;Cystic Fibrosis;cystic fibrosis patients;Data;Detection;detection limit;Development;Diagnosis;Diagnostic Procedure;Disease;Drug resistance;enantiomer;fluorodeoxyglucose positron emission tomography;Future;Goals;Gram-Positive Bacteria;High Pressure Liquid Chromatography;Human body;Image;Imaging Device;imaging modality;Imaging Techniques;Imaging technology;Immune response;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Inflammatory;interest;Label;Laboratories;Lead;Libraries;liquid chromatography mass spectroscopy;Lung;Magnetic Resonance;Mammalian Cell;Metabolic;metabolic imaging;Metabolic Pathway;Methods;Microbial Biofilms;microbiome;mimicry;Modeling;Monitor;Morphology;mortality;mouse model;novel;Nuclear Magnetic Resonance;Organism;pathogen;pathogenic bacteria;Pathogenicity;Patients;Peptidoglycan;Performance;perpetrators;Phase;Physicians;Pneumonia;pneumonia treatment;Positron-Emission Tomography;Pre-Clinical Model;Process;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;Pulmonary Cystic Fibrosis;pulmonary function decline;radiochemical;radiologist;Radiopharmaceuticals;radiotracer;Reporting;Resistance;Saline;Science;Signal Transduction;Solid;Specificity;Sputum;Tissues;Tracer;treatment response;uptake;Work;X-Ray Computed Tomography

PROJECT_TITLE: Sensing living P. aeruginosa using D-alanine derived radiotracers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative: This proposal responds to PAR-21-360 by examining the feasibility and acceptability of a time restricted feeding intervention among obese older adults with mild cognitive impairment. This one-arm trial will also examine preliminary changes in cognitive and metabolic function.

PI_NAMEs: SMITH, PATRICK JOSEY (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: acceptability and feasibility;Acute;acylcarnitine;Address;Adherence;Adult;adult obesity;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Animals;arm;Behavioral;beta-Hydroxybutyrate;Brain;Caloric Restriction;Carbohydrates;Cerebrum;Clinical;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive performance;cognitive testing;Collection;comorbidity;Complex;Consumption;Diet Modification;dietary;Dietary Practices;Eating;Energy Supply;Energy-Generating Resources;Enrollment;executive function;Fasting;fatty acid oxidation;Feasibility Studies;flexibility;Future;Geriatrics;Glucose;glucose metabolism;Glycosylated hemoglobin A;Goals;high risk;Hour;Human;human old age (65+);Impaired cognition;Impairment;improved;Incidence;Individual;Insulin;Intervention;ketogenic diet;Ketones;Kynurenic Acid;late life;lifestyle intervention;Link;Measures;Memory;Metabolic;Metabolic dysfunction;Metabolic Marker;Metabolic stress;Metabolic syndrome;Metabolism;mild cognitive impairment;Molecular;Nonpharmacologic Therapy;novel;Obesity;older adult;Organ;Participant;Pattern;Physiology;Pilot Projects;portability;post intervention;preservation;Procedures;Protocols documentation;Qualifying;Randomized;Reporting;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Sampling;satisfaction;Somatomedins;Source;standard measure;Time;Time-restricted feeding;Tryptophan;United States;Variant;Work

PROJECT_TITLE: Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Our goal is to understand how the immune system organizes in tumors and affects their growth and survival. Because the system is so complex, classical methods of microscopy cannot image the full immune response. Here we develop and apply leading-edge tools that merge genomics and imaging to study tumor immunity.

PI_NAMEs: CHEN, FEI  (contact);WU, CATHERINE JU-YING

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adoptive Transfer;Affect;analytical tool;Antigen Targeting;Antigens;Attention;Automobile Driving;Biological;cancer infiltrating T cells;Cells;Clinical;Clinical Pathology;Clinical Protocols;Clone Cells;Cloning;Complex;computer infrastructure;Cues;Data;Detection;detection sensitivity;Development;disorder control;DNA;DNA sequencing;Epitopes;exhaust;Generations;Genetic Heterogeneity;Genetic Transcription;genome-wide;genomic tools;Genomics;Goals;Growth;Histologic;Human;Image;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;immunogenic;Immunotherapy;improved;In Situ;Infiltration;insight;Knowledge;Link;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Melanoma;Memory;Methods;Microscopy;Modeling;Molecular;Mus;Mutation;Nature;neoantigen vaccine;neoantigens;neoplastic cell;Outcome;overexpression;parallelization;Pattern;Peptide/MHC Complex;Phenotype;Population;Positioning Attribute;reconstruction;Renal Cell Carcinoma;Resolution;RNA;Role;Sampling;Science;Slide;Space Perception;spatial integration;spatial relationship;Specificity;Specimen;Stromal Cells;success;System;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;treatment response;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Tissue;Vaccines;Viral;Viral Antigens;Work

PROJECT_TITLE: Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(09)F]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

PHR: Project Narrative. Mother-infant interactions that are characterized by shared positive affect and mutually responsive behavior facilitate the development of infant emotional self-regulation via co-regulation of infant neural systems. However, growing evidence suggests that this process is disrupted when the mother experiences postpartum depression. The proposed study has the potential to elucidate how postpartum depression impacts infant emotional self-regulation and, further, may help identify a specific mechanism, mother-infant biobehavioral synchrony, that could be targeted in future interventions.

PI_NAMEs: HIPWELL, ALISON E;MORGAN, JUDITH K. (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Affect;Affective;Anterior;Behavior;Behavior Therapy;Behavioral;biobehavior;Brain;Brain region;caregiving;case control;Case/Control Studies;Child;Clinical;Code;Cognitive;Data;depressive symptoms;design;Development;Disease;early childhood;emotion dysregulation;emotion regulation;Emotional;Environment;experience;Family;Film;Future;Home;Home environment;Home visitation;improved;Infant;Infant Development;Informal Social Control;Intervention;Interview;Investigation;Joints;Knowledge;Lateral;Life;maternal depression;Measures;Medial;Mediating;Mental Depression;mentalization;Methods;Modeling;Mothers;Near-Infrared Spectroscopy;negative affect;neural;neuroimaging;Neurophysiology - biologic function;Parents;Pathway interactions;Physiological;Physiology;Play;portability;Positive Valence;Postpartum Depression;Postpartum Period;Prefrontal Cortex;preventive intervention;Process;prospective;Questionnaires;Recording of previous events;Recovery;recruit;Reporting;Research;response;Risk;Sampling;screening;Severities;Shapes;social;social cognition;stressor;System;Testing;tool;Visit;Woman

PROJECT_TITLE: Mother-Infant Biobehavioral Synchrony and Postpartum Depression

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed work is relevant to public health because it will help enhance our understanding of genome organization. Because we develop generalizable tools, we will also bring our methods and results to bear on a broad range of ongoing health related research. Thus, the proposed project is relevant to NIH’s mission that seeks to obtain fundamental knowledge that will help to improve human health.

PI_NAMEs: DUAN, ZHIJUN ;MA, JIAN  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Biological;Biological Assay;Biological Process;Biology;Catalogs;Cell Nucleus;cell type;Cells;Chromatin;Communities;Complex;computerized data processing;computerized tools;Computing Methodologies;Data;Data Analyses;data exploration;data imputation;data platform;Data Set;Data Sources;Development;Disease;diverse data;empowerment;epigenomics;Evaluation;Excision;Formulation;functional genomics;functional outcomes;Gene Expression;gene function;Genome;genomic data;Genomics;graph neural network;Health;Hematopoiesis;hematopoietic differentiation;Heterogeneity;Hi-C;Human;Image;imaging modality;improved;Individual;interactive visualization;Intuition;Knowledge;Maps;Methods;Mission;Modeling;multimodal data;multimodality;Outcome;Population;population based;predictive modeling;Public Health;Research;Research Personnel;Resolution;Resources;Role;self supervised learning;Series;simulation;single cell analysis;Structure;Technology;three dimensional structure;Tissues;tool;United States National Institutes of Health;user-friendly;Validation;Variant;Visualization;Work

PROJECT_TITLE: Computational methods for studying single-cell 3D genome

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Project Narrative The goal of this project is to develop a novel immunotherapeutic platform for maintenance of remission of high-risk malignancies. Specifically, we will establish a method for thymic generation of naïve CAR T cells, enabling the continuous (but reversible if needed) production of cancer-specific T cells with massive proliferative capacity. We anticipate that our approach will be safe, providing long-lived tumor immunosurveillance to prevent relapse of aggressive lethal malignancies, addressing a particular urgent need in pediatric and young adult patients where additional modalities promoting long-term tumor control could significantly improve survival.

PI_NAMEs: ZAKRZEWSKI, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Adoptive Cell Transfers;Affect;Affinity;Allogenic;Antigen Receptors;antigen-specific T cells;Antineoplastic Agents;Area;B-Lymphocytes;Biological;Biological Assay;Biological Models;Biology;Bioreactors;Bone Marrow;Bypass;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;Cause of Death;CD19 gene;CD28 gene;Cell Lineage;Cell Maintenance;cell motility;Cells;cellular engineering;cellular transduction;chemotherapy;Childhood;Childhood Acute Lymphocytic Leukemia;chimeric antigen receptor T cells;Clinical;clinical application;clinically relevant;conditioning;Consolidation Therapy;cytokine release syndrome;Data;design;Development;Disease remission;disorder control;engineered stem cells;Engraftment;Epithelium;exhaustion;Gene Expression;Gene Transfer;Generations;genetic manipulation;Goals;hematopoietic engraftment;Hematopoietic stem cells;high risk;Homing;Human;Human Activities;humanized mouse;image guided;Immunity;Immunologic Surveillance;Immunotherapeutic agent;improved;In Vitro;in vivo;Injections;innovation;intravenous administration;irradiation;Laboratories;leukemia/lymphoma;Longitudinal Studies;Maintenance;Malignant - descriptor;Malignant neoplasm of thymus;Malignant Neoplasms;manufacture;Mediating;Methods;minimally invasive;Modality;Modeling;Modern Medicine;Molecular;molecular targeted therapies;mouse model;Mus;neoplastic cell;novel;Outcome;overexpression;Pathway interactions;patient derived xenograft model;patient population;Patients;Peripheral;Phenotype;Pre-B Acute Lymphoblastic Leukemia;pre-clinical assessment;preclinical efficacy;preservation;Procedures;Production;Protocols documentation;Publishing;rational design;receptor;Relapse;relapse prevention;relapse risk;Remission Induction;Research;Risk Reduction;secondary lymphoid organ;self-renewal;Signal Transduction;single-cell RNA sequencing;Specificity;System;T cell differentiation;T cell reconstitution;T cell therapy;T-Cell Development;T-Cell Transformation;T-Lymphocyte;Technology;Testing;Thymus Gland;Time;Transfusion;transgene expression;translational immunology;translational study;tumor;Tumor Antigens;Tumor Burden;tumor specificity;Variant;young adult

PROJECT_TITLE: Harnessing the thymus for long-term tumor control with hematopoietic stem cell-derived naive CAR T cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This longitudinal observational study examines multiple levels of Structural Racism and Discrimination (SRD) including individual (both intrapersonal and interpersonal), neighborhood, institutional, and societal/policy and their associations with mental, physical, and behavioral health outcomes across the life course. Innovative mixed-methods (e.g., ecological momentary assessment, geographic information system data, community- based participatory approaches, biomarkers) are being used at two sites (Minnesota, Georgia), across two time points 18 months apart, with families from racially/ethnically and socioeconomically diverse households (n=927). Study findings will identify targets for intervening at multiple SRD levels to promote health equity.

PI_NAMEs: BERGE, JERICA M;FERTIG, ANGELA RICE (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Adolescence;Adult;Affect;African American;anxiety symptoms;behavioral health;Biological;Biological Markers;Black race;Blood Pressure;Body mass index;C-reactive protein;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;career development;Child;Childhood;Communities;community based participatory approach;cytokine;Data;depressive symptoms;design;Diet;Dietary intake;Discrimination;Ecological momentary assessment;Elements;ethnic diversity;Ethnic Origin;Event;Exposure to;Family;Geographic Information Systems;Geographic Locations;Glycosylated hemoglobin A;Health;health disparity;health equity;health equity promotion;Heart Rate;Hemoglobin C;High Density Lipoprotein Cholesterol;Hispanic;Household;Housing;Immigrant;Individual;innovation;Institution;Institutional Racism;Intervention;killings;Life Cycle Stages;Lipids;Longitudinal cohort study;Longitudinal Studies;Longitudinal, observational study;Measures;Mental Depression;Mental Health;Methods;Minnesota;Moods;multidisciplinary;Native Americans;negative mood;Neighborhoods;Outcome;Outcome Measure;Parents;Participant;perceived discrimination;perceived stress;Personal Satisfaction;Persons;Physical activity;physical conditioning;Police;Policies;Prevalence;prospective;Psyche structure;Public Assistance;Public Health;Race;racial diversity;racism;Refugees;Reporting;Research;Research Design;Research Personnel;Risk Factors;Rural;rural families;rural setting;Safety;Sampling;Schools;sedentary lifestyle;segregation;Site;socioeconomics;Source;Stress;Structural Racism;Surveys;therapy development;Time;Triglycerides;Unhealthy Diet;United States;urban setting;Voting;waist circumference;Well in self;Work

PROJECT_TITLE: Multi-level predictors of structural racism and discrimination and associations with health and well-being across the life course in diverse families


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Alzheimer’s disease is the sixth leading cause of death in the United States with no effective treatment, and the number of patients will triple by 2050. Inhibition of an enzyme called soluble epoxide hydrolase (sEH), which hydrolyzes endogenous largely beneficial epoxy fatty acid to proinflammatory dihydroxy fatty acid, alleviates Alzheimer’s pathological hallmarks and symptoms, like neuroinflammation, tauopathy, amyloidosis and, cognitive dysfunctions suggesting that sEH inhibitor is a rational therapeutic target. This project aims to develop a novel sEH inhibitor with high potency, significantly improved CNS drug-like properties, and CNS exposure to treat Alzheimer’s disease.

PI_NAMEs: LEE, KIN SING STEPHEN  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acids;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloidosis;analog;Animal Diseases;Animal Model;Binding;Biological;Biological Assay;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;candidate selection;Cause of Death;Chronic;clinical candidate;clinical development;cognitive function;Computer Models;Data;Dementia;design;Development;Disease;Dose;drug discovery;Drug Kinetics;Drug Targeting;effective therapy;efficacy evaluation;efficacy testing;Enzyme Inhibition;Enzymes;Epoxide hydrolase;experience;experimental study;Exposure to;Fatty Acids;Genetic;Goals;human old age (65+);Impaired cognition;improved;In Vitro;in vivo;Inflammatory;inhibitor;inhibitor therapy;Kinetics;Knock-out;Lead;lead candidate;Learning;Letters;Medical;Methodology;Modeling;Modification;multidisciplinary;Mus;nanomolar;Neurodegenerative Disorders;neuroinflammation;new therapeutic target;novel;Oral;Parkinson Disease;Pathogenesis;Pathologic;Patients;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacophore;physical property;Plasma;Population;pre-clinical;preclinical efficacy;preclinical study;Preclinical Testing;prevent;programs;Property;Quality of life;Rattus;Reporting;Research;research and development;residence;Series;Structure-Activity Relationship;Symptoms;System;Tauopathies;Testing;Therapeutic;therapeutic target;Time;tool;United States;vascular abnormality

PROJECT_TITLE: Development of soluble epoxide hydrolase inhibitors for the treatment of Alzheimer's disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the major cause of dementia and selectively affects certain brain cell types. However, current single-cell technology limits the ability to study this on a large scale across multiple omics, such as DNA, RNA, and protein. To fill this knowledge gap, we will develop and implement statistical methods that will leverage existing rich tissue-level and limited single-cell omics data, with the goals of increasing our understanding of cellular mechanisms underlying AD and informing future prevention and treatment strategies.

PI_NAMEs: MCKENNAN, CHRISTOPHER ;WANG, JIEBIAO  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Address;Affect;age acceleration;aging population;Alzheimer's Disease;Behavior;Biology;Brain;brain cell;Brain region;brain tissue;Cell Lineage;cell type;Cells;Cessation of life;Child;Clinical;cohort;Communities;Complement;Complex;Computational algorithm;Computer software;Computing Methodologies;cost;cost efficient;Data;Data Analyses;Data Set;Dementia;Dependence;Development;DNA;DNA Methylation;epigenome;Functional disorder;Future;Gene Expression;Genes;genome-wide;Genotype;Goals;high dimensionality;Human;improved;innovation;insight;Intervention;Knowledge;Late Onset Alzheimer Disease;Learning;Masks;Mediation;Medicine;Methods;Methylation;Multiomic Data;multiple omics;National Institute on Aging;novel;Parents;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Population;Prevention;Prevention strategy;Problem Solving;progressive neurodegeneration;Proteins;Proteome;Proteomics;Research;Resolution;RNA;Role;Sample Size;Sampling;Signal Transduction;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Solid;Specificity;Statistical Methods;Statistical Models;statistics;Techniques;Technology;Testing;Tissue Sample;Tissues;tool;transcriptome;treatment strategy;Variant

PROJECT_TITLE: Statistical methods for population-level cell-type-specific analyses of tissue omics data for Alzheimer's disease

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Vector-Borne Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE We found that hematopoietic stem cells accumulate ascorbate, which regulates stem cell function and suppresses myelopoiesis. We propose to test if ascorbate deficiency promotes the generation of inflammatory myeloid cells in steady state conditions and after plasmodium infection. We will test if increased myelopoiesis caused by ascorbate deficiency is deleterious in plasmodium infection.

PI_NAMEs: AGATHOCLEOUS, MICHALIS  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;adult stem cell;ascorbate;Ascorbic Acid;Bacteremia;Biological Assay;Blood Cells;Bone Marrow;Cell Lineage;Cell Separation;cell type;Cells;Clonal Expansion;cofactor;Communicable Diseases;COVID-19;cytokine;Data;Diet;Elderly;enzyme activity;Enzymes;Evolution;experimental study;Frequencies;Generations;Genetic Engineering;Gulo;gulonolactone;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;high risk;Human;human model;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;L-gulonolactone oxidase;leukemogenesis;loss of function mutation;Malaria;malaria infection;Measures;Mediating;metabolic profile;metabolome;metabolomics;Methods;Morbidity - disease rate;mortality;mortality risk;mouse model;Multipotent Stem Cells;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Nature;novel;Organism;Outcome;Oxidases;Parasites;Pathogenesis;Pathogenicity;Pathology;Persons;Phenotype;Physiological;Plasma;Plasmodium;Plasmodium chabaudi;Population;Primates;progenitor;Public Health;Regulation;response;Rodent;Role;sodium DEPENDENDENT vitamin C transporter 1;Spleen;stem;stem cell function;stem cells;Testing;Tissues;Transplantation;Variant;Vertebrates;Work

PROJECT_TITLE: The role of ascorbate in myelopoiesis and infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE As about a tenth of the population over 70 ages, a clonal population of mutated leukocytes, namely clonal hematopoiesis, arises that is typically benign in nature. Studies from our laboratory has shown that the outgrowth of these clonal populations, is linked to a casual role in the development of heart diseases. In our studies, we hope to fill the gap in knowledge by determining the mechanism behind this causal link in primary human models of clonal hematopoiesis.

PI_NAMEs: MITCHELL, SHANEICE R. (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Address;Age;age related;Aging;Alleles;Antibodies;Atherosclerosis;atherosclerosis risk;Benign;Biological Assay;Bone Marrow Cells;Cardiovascular Diseases;Cause of Death;CD34 gene;Cells;Chronic;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cytokine;Death Rate;Development;Disease;DNMT3a;Elderly;engineered stem cells;Engineering;Epigenetic Process;Exposure to;Gene Expression Profile;General Population;Genetic Polymorphism;Genetic Transcription;Genotype;Goals;Heart Diseases;Heart failure;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;high risk;Human;human model;humanized mouse;hypercholesterolemia;Hypertension;Imaging technology;Immunodeficient Mouse;in vivo;in vivo engraftment;Individual;Inflammation;Inflammatory;insight;interest;Interleukin 6 Receptor;Interleukin-6;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;leukemia;Leukocytes;Link;Lipopolysaccharides;loss of function mutation;Low-Density Lipoproteins;Macrophage;Measures;Mediating;Mentors;Minority Participation;Modeling;mortality;mouse model;Multiplexed Ion Beam Imaging;Mus;Mutate;Mutation;Myeloid Cells;Myocardial Infarction;Nature;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Pharmacologic Substance;Phase;Phenotype;Physiology;Population;Prevalence;Production;protective effect;Protein Isoforms;Protocols documentation;Public Health;Receptor Gene;Reporting;Research Personnel;Risk;Risk Factors;Role;Science;Signal Pathway;single-cell RNA sequencing;Stroke;Surface;System;transcriptome sequencing;transcriptomics;Transgenic Mice;Transplantation;Variant;Work

PROJECT_TITLE: Investigating the Pathological Features of Clonal Hematopoiesis-derived Macrophages


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Nutrition;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Necrotizing fasciitis (NF) is a consequence of bacterial infection characterized by extensive tissue destruction. NF is considered a medical emergency requiring hospitalization, systemic antibiotics and surgery to remove dead/dying tissues. Mortality of NF is extremely high and new therapies are required. In this study, we test whether changing metabolism in infected tissues provides resistance to tissue damage thereby reducing treatment costs and increasing survival rates.

PI_NAMEs: BENSINGER, STEVEN J (contact);SCUMPIA, PHILIP

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: advanced analytics;Affect;Antibiotics;Attenuated;Bacillus anthracis;Bacteria;Bacterial Infections;Binding;Biological Assay;Cell membrane;Cell Reprogramming;cell type;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Critical Pathways;Cytolysins;Cytoprotection;cytotoxicity;Data;Death Rate;Debridement;Dermis;design;Disease;Disease Progression;Eating;Effectiveness;Elements;Exotoxins;experimental group;Fascia;Fatty acid glycerol esters;Functional disorder;gain of function;Gene Expression;Genetic;Goals;Grant;Homeostasis;Hospitalization;Host Defense;Image;Immune;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Integration Host Factors;intradermal injection;Laboratories;Learning;Life;lipid metabolism;lipidomics;Lipids;Liver X Receptor;loss of function;Macrophage;Mass Spectrum Analysis;Measures;Mediating;Medical emergency;Membrane;Metabolic;Metabolic Pathway;Metabolism;Methodology;Microbe;microbial;Modeling;Molecular;monomer;Morbidity - disease rate;mortality;mouse model;Necrosis;Necrotizing fasciitis;neutrophil;new therapeutic target;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Permeability;Phagocytes;pharmacologic;Play;Process;Productivity;programs;protective effect;Proteins;Research Design;Resistance;Role;Sepsis;Signal Pathway;Signal Transduction;single cell sequencing;Skin;Skin Tissue;soft tissue;Soft Tissue Infections;Streptococcus pyogenes;Streptolysins;Survival Rate;Techniques;Testing;Therapeutic;Therapeutic Uses;Tissue Preservation;Tissues;Toxic effect;Toxin;transcriptomics;Treatment Cost;Vibrio vulnificus;Virulence;Virulence Factors;Work

PROJECT_TITLE: Targeting host lipid metabolism to limit tissue damage in necrotizing fasciitis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Immunization;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Mounting evidence links perturbations in early life host-microbiota interactions with increased susceptibility to immune-mediated diseases later in life, yet we lack a mechanistic understanding of how mutually beneficial relationships between gut bacteria and the neonatal immune system are formed. Building from our discovery that maternal antibodies, delivered via breastfeeding, are key regulators of intestinal homeostasis, this proposal seeks to define the cellular and molecular mechanisms by which maternal antibodies restrain aberrant immune responses to gut bacteria in early life. The resulting data will advance our understanding of the immunological processes that regulate nascent host-microbiota interactions, thereby aiding in our ability to manipulate mucosal immune responses in early life to promote long-term health.

PI_NAMEs: KOCH, MEGHAN ANNE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Adult;Animals;anti-microbial peptide;Antibodies;antigen binding;Antigen-Antibody Complex;Antigens;Area;B-Lymphocytes;Bacteria;Benign;Binding;Breast Feeding;CD4 Positive T Lymphocytes;cell type;Cells;Chemicals;chemokine;Colitis;commensal bacteria;commensal microbes;Complement Activation;Complement Receptor;Data;Dendritic Cells;Development;dietary;Disease;draining lymph node;Education;Equilibrium;Fc domain;Fc Receptor;feeding;Flow Cytometry;Food;Fostering;gastrointestinal epithelium;Goals;gut bacteria;gut inflammation;gut microbes;Health;Health Promotion;Helper-Inducer T-Lymphocyte;Homeostasis;host microbiota;host-microbe interactions;Human;Human Milk;Hypersensitivity;IgG1;IgG3;Immune;immune health;Immune response;Immune System Diseases;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;Infant;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;Ingestion;innovation;insight;intestinal homeostasis;Intestines;Knowledge;Lactobacillus;Lead;Life;Ligation;Link;Maternal antibody;Mediating;mesenteric lymph node;Metabolic dysfunction;microbiota;microbiota composition;microorganism antigen;Milk;Molecular;Morbidity - disease rate;Mothers;mouse model;Mucosal Immune Responses;Mucosal Immune System;Mucosal Immunity;Mucous body substance;Mucous Membrane;mutualism;Neonatal;neonatal immune system;neonatal immunity;neonate;neutralizing antibody;nutrition;offspring;Oral Administration;Ovalbumin;pathogen;Play;Predisposition;prevent;Process;Production;RANTES;receptor function;recruit;Research;resident commensals;response;restraint;Role;Severity of illness;Shapes;Signal Pathway;Signal Transduction;Site;Solid;Specificity;Structure of germinal center of lymph node;suckling;T cell response;Testing;Transgenic Mice;transmission process;Weaning;Work;wound;XCR1 gene

PROJECT_TITLE: Breastmilk antibodies regulate neonatal immunity to the microbiota

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Patients initiating hemodialysis for advanced kidney failure enter a period of profound risk for morbidity and mortality, they frequently present with marked hypervolemia, and often experience a rapid decline in urine output and residual renal function. Sacubitril/valsartan, a dual inhibitor of the renin-angiotensin system and the counter- regulatory vasoactive peptide system, is known to reduce signs and symptoms of congestion, and slow decline in renal function in patients with heart failure (compared with RAS inhibitors). Building on these data, our pilot randomized placebo-controlled clinical trial will evaluate the effect of sacubitril/valsartan on echocardiographic measures of hypervolemia, preservation of residual renal function, and key safety parameters in incident hemodialysis patients, and thereby inform the design of a larger multi-center study to evaluate hard clinical outcomes.

PI_NAMEs: MCCAUSLAND, FINNIAN R (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;adverse outcome;Angiotensin Receptor;Angiotensins;Biological;Blood Pressure;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;Clinical Trials;Clinical Trials Cooperative Group;clinically relevant;Creatinine;Data;Death Rate;design;Development;Diabetes Mellitus;Diameter;Double-Blind Method;Echocardiography;Event;evidence base;Exclusion;experience;Fibrosis;Fluid overload;Frequencies;functional decline;Functional disorder;Goals;Heart Atrium;Heart failure;Hemodialysis;hemodynamics;high risk;hyperkalemia;Hypertension;hypertensive;Hypotension;improved;indexing;Inferior vena cava structure;Inflammation;inhibitor;innovation;Kidney;Kidney Diseases;Kidney Failure;Left;Left atrial structure;Left Ventricular Mass;Maintenance;Measures;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;Neprilysin;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Outcome;Output;Patient Care;patient oriented;Patients;Peptides;Performance;Perfusion;pharmacologic;Phenotype;Physiological;Pilot Projects;pilot trial;Placebo Control;Placebos;Population;Potassium;Predisposition;preservation;pressure;pro-brain natriuretic peptide (1-76);Property;Randomized;randomized placebo controlled trial;randomized placebo-controlled clinical trial;Renal function;Renin-Angiotensin System;Reporting;Residual state;Risk;Safety;safety testing;saluretic;Serum;Signs and Symptoms;Stress;structural heart disease;symptomatic improvement;System;Testing;Therapeutic;Time;Ultrafiltration;United States;Urea;Urine;valsartan

PROJECT_TITLE: Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_CITY: Baltimore

ORG_NAME: SCANOGEN, INC.

ORG_STATE: MD

PHR: Project Narrative We propose the development of a novel sample-to-answer ID/AST test for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria directly on whole blood for the diagnosis of patients suspected of bloodstream infections.

PI_NAMEs: CELEDON, ALFREDO ANDRES (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acinetobacter baumannii;Agreement;Anti-microbial susceptibility;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Biological Assay;Blood;Blood Circulation;Blood specimen;Categories;Clinical;cost effective;Detection;detection limit;detection method;Development;Diagnosis;Diagnostic;diagnostic platform;effective therapy;Enterobacter;Escherichia coli;Goals;Hour;Incubated;instrument;Klebsiella pneumoniae;Liquid substance;Methods;microorganism;multiplex assay;novel;operation;Organism;pathogen;Patients;Performance;Pharmaceutical Preparations;Phenotype;Physicians;Predisposition;Process;Protocols documentation;prototype;Pseudomonas aeruginosa;Rapid diagnostics;rapid test;Reagent;Reference Standards;Resistance;Ribosomal RNA;Sampling;Sepsis;single molecule;Specificity;Staphylococcus aureus;System;targeted treatment;Techniques;Testing;Time;Whole Blood

PROJECT_TITLE: Rapid ID and AST Directly from Whole Blood Using Single Molecule Detection


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative Malassezia are lipid-dependent yeasts that are part of the normal commensal microbiome on human skin, and they are also associated with several skin diseases and implicated as playing a pathogenic role in Crohn's Disease, pancreatic cancer, and exacerbation of Cystic Fibrosis. In parallel, Candida auris has emerged globally as a human fungal pathogen that is frequently hospital-acquired and drug-resistant; this pathogen initially colonizes the skin and then causes systemic infections that are a significant cause of morbidity and mortality. This proposal aims to apply recently developed genomics and genetics resources (combined with models of host-pathogen and microbial interactions) to elucidate molecular mechanisms of Malassezia pathophysiology in dysbiosis of the skin microbiome as a risk factor for Candida auris colonization and infection and provide insights to advance diagnosis, treatment, and prevention approaches and thereby improve human health.

PI_NAMEs: HEITMAN, JOSEPH  (contact);LEIBUNDGUT-LANDMANN, SALOME

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Allergens;Animals;anti-fungal agents;Antibiotics;Atopic Dermatitis;Bacteria;Biology;Calcineurin;Candida;Candida auris;Clinical Pathology;commensal microbes;Complex;Consensus;Coupled;Crohn's disease;Cutaneous;Cystic Fibrosis;Data;Diagnosis;Diagnostic;Disease;Distal;Double Stranded RNA Virus;Double-Stranded RNA;drug action;Drug resistance;dysbiosis;Eczema;Evolution;Exclusion;Foundations;Functional disorder;fungus;Gastrointestinal tract structure;Gene Deletion;Generations;Genes;Genetic;genetic manipulation;genetic resource;genetic technology;Genetic Transcription;genome annotation;genome resource;Genomics;Goals;Growth;Health;Homeostasis;Hospitals;Human;Immune response;Immune system;Immune System Diseases;Immunity;improved;In Vitro;in vivo;in vivo Model;Infection;Infectious Skin Diseases;Inflammation;Inflammatory Response;insight;keratinocyte;Knowledge;Life Style;Link;Lipids;lipophilicity;Lung;Macrophage;Malassezia;Malignant neoplasm of pancreas;Mediating;Microbe;microbial host;Microbiology;microorganism interaction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;mycobiome;Nature;novel;Outcome;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;Patients;Pattern;Peptide Hydrolases;Phenotype;Play;Prevention approach;prognostic;Protein Secretion;Proteins;Proteomics;reference genome;resident commensals;response;Rhizobium radiobacter;Risk;Risk Factors;Role;Satellite RNA;Sepsis;Signal Transduction;Site;Skin;skin barrier;Skin colonization;skin disorder;skin microbiome;skin microbiota;STEM research;Systemic infection;Techniques;telomere;Testing;Tinea Versicolor;tool;transcriptome sequencing;Translations;tumor progression;Viral;viral RNA;Virulence;Virulence Factors;Virus;Yeasts

PROJECT_TITLE: Malassezia and Candida auris: skin microbiome dysbiosis and de-regulation of cutaneous homeostasis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PHR: Project Narrative  This application seeks to advance statistical methods for high-dimensional multiple disease mapping and boundary detection when the number of diseases and space-time coordinates can be massive. The proposal introduces new graphical process-based models for high-dimensional disease mapping while accounting for spatial misalignment when incorporating multi-source information from climate and other environmental factors, which will enrich epidemiologic analysis of diseases in relation to environmental, climate and socio-demographic factors.

PI_NAMEs: BANERJEE, SUDIPTO  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Algorithms;Area;Atlas of Cancer Mortality in the United States;Attention;Bayesian Analysis;Bayesian learning;Bayesian Method;Bayesian Modeling;cancer type;Censuses;Climate;Collection;Complex;Computer software;computerized;Computing Methodologies;County;Data;Data Scientist;Data Set;Databases;Dependence;Detection;Development;Dimensions;Disease;Disparate;Endowment;Environment;Environmental Pollutants;Environmental Risk Factor;Epidemiologic Methods;Epidemiologist;Epidemiology;Etiology;Exercise;Explosion;Funding;geographic difference;Geographic Information Systems;Geography;Graph;graphical user interface;Health;high dimensionality;High-dimensional Modeling;Incidence;innovation;interest;Internet;Learning;Link;Malignant Neoplasms;Maps;Markov chain Monte Carlo methodology;Methodology;Methods;Modeling;mortality;Mortality Map;National Cancer Institute;novel;Outcome;Prevalence;Process;Public Health;Publishing;Research Personnel;Resolution;Risk;Sample Size;sociodemographic factors;socioeconomics;Source;spatiotemporal;Statistical Computing;Statistical Methods;Statistical Models;statistics;Stochastic Processes;Technology;technology platform;Time;trend;user friendly software;web interface

PROJECT_TITLE: Bayesian Modeling and Inference for High-Dimensional Disease Mapping and Boundary Detection"