NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Genetics;Lung;Physical Injury - Accidents and Adverse Effects;Precision Medicine

PROJECT_TERMS: Address;Adolescent;Adult;age difference;age effect;Animals;Architecture;assay development;biodosimetry;Biological Assay;Biological Markers;Biological Models;biomarker identification;Biostatistics Core;Blood;Blood specimen;Cessation of life;Complex;Coupled;Cytogenetics;Data;Decision Trees;Development;Devices;Disease Progression;Dose;Dose Rate;Event;Experimental Models;exposed human population;Exposure to;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;genetic signature;Goals;Human;improved;in vivo;Individual;irradiation;Knowledge;Late Effects;Lung;Lung Diseases;lung injury;Measures;metabolomics;Methodology;minimally invasive;Modeling;mouse model;Mus;Neutrons;nonhuman primate;Nuclear;Nuclear Accidents;old mice;Outcome;outcome prediction;Performance;Photons;predictive signature;Pulmonary Inflammation;Radiation;radiation effect;Radiation exposure;Radiation Injuries;Radiation Pneumonitis;reconstruction;response;senescent cell;survival prediction;Testing;Time;transcriptome sequencing;transcriptomics;transgenic suicide gene;urban area;Whole-Body Irradiation

PROJECT_TITLE: Radiation Biodosimetry using Gene Expression Signatures


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung;Physical Injury - Accidents and Adverse Effects;Precision Medicine

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: FORNACE, ALBERT J (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Affect;age effect;Animal Model;Animals;biodosimetry;Biological Assay;Biological Markers;Biological Models;biomarker identification;Biostatistics Core;Blinded;C57BL/6 Mouse;C57L/J Mouse;Cessation of life;Chest;cohort;Core Facility;Coupled;Cytogenetics;Data Set;Databases;Decision Trees;Development;Disease;Disease Progression;Dose;dose individualization;Dose Rate;Equilibrium;Event;experimental study;exposed human population;Exposure to;Extensive Radiation;Facility Designs;Gene Expression;Goals;Health;Human;Individual;Injury;interdisciplinary approach;irradiation;Late Effects;Late Radiation Injury;Link;Lung;Lung Diseases;lung injury;metabolomics;minimally invasive;Mus;Neutrons;old mice;Outcome;personalized predictions;Photons;predictive marker;predictive signature;programs;Pulmonary Inflammation;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Injuries;Radiation Pneumonitis;Radiation Tolerance;radiation-induced injury;reconstruction;Recovery;Research;response;Sampling;senescent cell;Serum;Signal Transduction;System;TBI Patients;Testing;Time;transcriptomics;Transgenes;Translations;Urine;Validation

PROJECT_TITLE: Rapid Non-invasive Radiation Biodosimetry through Metabolomics


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Cardiotoxicity is a serious side effect that occurs in up to a third of cancer patients receiving anthracycline chemotherapy. This project will utilize cell and animal models to define how interactions between cardiac innate immune responses and mitochondrial dysfunction contribute to the development and progression of anthracycline-induced cardiotoxicity. This research may therefore have a positive impact on public health by identifying new biomarkers for cardiotoxicity and/or illuminating novel therapeutic approaches to prevent or slow chemotherapy-related heart damage.

PI_NAMEs: WEST, ANDREW PHILLIP (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Acute;Adjuvant;Animal Model;Animals;Anthracycline;Antineoplastic Agents;Attenuated;Automobile Driving;biomarker identification;Cancer Patient;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;Cardiovascular Diseases;Cell Death;Cell model;Cells;Cessation of life;chemotherapy;Chronic;clinical application;combat;conditional knockout;coronary fibrosis;Defect;Development;DNA;DNA Damage;Doxorubicin;Echocardiography;Exhibits;experience;Failure;Female;Functional disorder;Gene Expression;Genes;Goals;Health;Heart;heart damage;Heart failure;Homeostasis;Human;human induced pluripotent stem cells;Image;Immune signaling;Impairment;in vivo;induced pluripotent stem cell derived cardiomyocytes;Inflammation;Inflammatory Response;innate immune mechanisms;innate immune pathways;Innate Immune Response;innovation;insight;Interferon alpha;Interferon Type I;interferon-alpha B;Interferons;Iron;Iron Overload;Kinetics;Knockout Mice;Left ventricular structure;Life;Link;Longitudinal Studies;male;Malignant Neoplasms;Mediating;Melanoma;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;Mus;Muscle Cells;Myelogenous;Myeloid Cells;myocardial damage;Myocardial dysfunction;novel;novel therapeutic intervention;Oxidative Stress;paracrine;Pathology;Pathway interactions;Patients;Population;predictive marker;Prevalence;prevent;Production;programs;Public Health;Reactive Oxygen Species;receptor;Receptor Signaling;Reporter;Research;response;Role;side effect;Signal Transduction;Source;Stimulator of Interferon Genes;synergism;Testing;Therapeutic;Time;Tissues;Toxic effect;transcriptome sequencing;Treatment-Related Cancer;tumor;Up-Regulation;Ventricular Remodeling;Work;Z-DNA Binding Protein

PROJECT_TITLE: Type I Interferon Responses in the Pathobiology of Anthracycline-induced Cardiotoxicity

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: Arlington

ORG_NAME: ISA ASSOCIATES, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE The goal of this project is to develop a patient-facing cervical cancer behavioral intervention (mNav) to help African American women identify and overcome barriers to cervical cancer care by providing health education and promoting self-efficacy, health literacy, and communication with healthcare providers. mNav-D, an integrated dashboard, will help lay navigators focus on issues they are best suited to handle (e.g., problems with insurance or transportation). The ultimate goal of this suite of products is to eliminate cervical cancer disparities among African American women.

PI_NAMEs: BILLINGS, DOUGLAS W (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Adherence;African American population;African American Women;Age;Attention;Behavior Therapy;Benchmarking;black patient;black women;Breast Cancer Prevention;cancer care;cancer health disparity;cancer prevention;Caring;Case Management;Cellular Phone;Cervical;Cervical Cancer Screening;Communication;Communities;Community Health Aides;Complex;Computer software;Consultations;dashboard;Data;design;Development;Devices;Diagnosis;Diagnostic;Disease;Disparity;Effectiveness;effectiveness evaluation;Electronic Health Record;Emotional;follow-up;Funding;Goals;Health education;health literacy;Health Personnel;Health Promotion and Education;Hispanic;Hysterectomy;improved;Incidence;Insurance;Intervention;Interview;Knowledge;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Marketing;Measures;Medical;member;Morbidity - disease rate;mortality;mortality disparity;National Cancer Institute;Not Hispanic or Latino;Online Systems;outreach;Participant;patient navigation;Patients;Performance;Phase;Pilot Projects;premalignant;product development;programs;prototype;Provider;Public Health;Randomized;Research;Resolution;Risk Assessment;screening;screening disparities;Screening for cancer;screening guidelines;Self Efficacy;Services;skills;socioeconomic disadvantage;success;Testing;Text Messaging;Time;tool;Transportation;treatment as usual;Trust;Tumor stage;Underserved Population;Uninsured;video delivery;White Women;Woman;Work

PROJECT_TITLE: Enhancing the Effectiveness of Community Health Workers to Reduce Cervical Cancer Disparities in African American Women


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Malaria elimination remains a global health priority, but as regions near elimination they are often “vulnerable” to re-introduction of malaria from areas nearby with high transmission and “receptive” as they have the right ecology to support transmission. Evidence is needed to design interventions to help pre-elimination settings reach the last mile of elimination. This proposal seeks to provide the evidence base to help develop the tools needed for control programs to face this challenge.

PI_NAMEs: JULIANO, JONATHAN J (contact);LIN, JESSICA ;NGASALA, BILLY

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Africa;Annual Reports;Anti-malarials;Area;Case Study;Clinical;Collaborations;Communities;Country;Culicidae;Data;design;Detection;Diagnostic tests;Disease Outbreaks;disease transmission;Ecology;evidence base;Face;Future;Genetic;genome sequencing;genome-wide;genomic data;Genomics;Genotype;global health;Goals;Health care facility;Health Priorities;High-Throughput Nucleotide Sequencing;Household;Human;identity by descent;indexing;Individual;Infection;Institution;International;Interruption;Intervention;Island;Legal patent;Link;Malaria;malaria transmission;Maps;Measures;Methods;migration;Modeling;Molecular;novel;Parasites;Pattern;Plasmodium falciparum;Policies;predictive modeling;prevent;Productivity;programs;Rapid diagnostics;Recording of previous events;Reporting;Research;Research Priority;Residual state;Resolution;response;Risk;Risk Factors;Route;Sampling;screening;Shapes;Site;Source;Spatial Distribution;Tanzania;targeted sequencing;therapy design;Time;tool;Transcend;transmission process;Travel;vector;vector control;Vulnerable Populations;whole genome;Zanzibar

PROJECT_TITLE: Importation and transmission of malaria in Zanzibar: a case study for elimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative  We will develop a DNA editing platform to eliminated mutant mtDNA (mitoARCUS) in human and mouse models. In addition, we will test a newly described base editing tool (DdCBE) to edit mitochondrial DNA in a mouse model.

PI_NAMEs: MORAES, CARLOS TORRES (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Alanine-Specific tRNA;Architecture;base editing;base editor;Biological Sciences;Clinical;clinical practice;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Compensation;Cultured Cells;Cytosine;dimer;Disease;DNA;ds-DNA;endonuclease;Enzymes;established cell line;functional restoration;gene therapy;Genes;Goals;Grant;Guide RNA;heteroplasmy;Homing;Human;human model;Impairment;in vivo;in vivo Model;induced pluripotent stem cell;Leucine-Specific tRNA;Liver;MELAS Syndrome;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial gene replacement;Modeling;monomer;Motor Neurons;mouse model;Mus;Muscle;mutant;Mutate;Mutation;Names;Organoids;Oxidative Phosphorylation;Pathogenicity;Patients;Repetitive Sequence;Retina;Retinal Ganglion Cells;Structure;System;Testing;Thymidine;tool;transcription activator-like effector nucleases;Translating;Viral Packaging;Work

PROJECT_TITLE: Setting the Stage for Replacement of Mitochondrial Genes

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Immunotherapy

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Activated naïve T cells differentiate into memory and effector populations with unique functional and molecular profiles, which express the key inhibitory receptor programmed cell death protein 1 (PD-1) to limit excessive T cell-mediated autoreactivity. PD-1 is a prime immunotherapeutic target and despite its well-established role in immune tolerance, little is known about the molecular programs that support PD-1 inhibition under the prism of vast cellular and molecular diversity within the T cell population. The proposed research aims to dissect the PD-1 signalosome across the trajectory of diverse functional T cell states and to identify the cellular and molecular mediators of PD-1 responsivity.

PI_NAMEs: TOCHEVA, ANNA S (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Advanced Development;Affinity;Autoimmunity;Automobile Driving;autoreactivity;Bar Codes;Binding;Biology;Blocking Antibodies;Cancer Patient;Cellular biology;Clinical;Complex;Data;Dependence;Development;effector T cell;Etiology;Foundations;functional genomics;Generations;Genetic Transcription;Heterogeneity;Homeostasis;Human;Immune response;Immune Tolerance;Immunoassay;Immunotherapeutic agent;improved;Infection;Inflammatory;Knowledge;Ligands;Maintenance;Malignant Neoplasms;Mediating;Mediator;Memory;Molecular;Molecular Profiling;novel therapeutics;Pathway interactions;Patients;Pattern;Phenotype;phosphoproteomics;Phosphorylation;Population;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;receptor;Research;Resistance;Role;Shapes;Signal Transduction;single-cell RNA sequencing;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-cell diversity;T-cell inflamed;T-Lymphocyte;targeted treatment;Tissues;Toxic effect;tumor;Tumor Escape

PROJECT_TITLE: Molecular mechanisms underlying T cell resistance to PD-1 signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Of persons living with HIV, up to 90% have been infected with hepatitis B and up to 10% have chronic hepatitis B, but currently no cure is available. Using novel techniques and specimens, this proposal will provide data on the role of the humoral immune response including neutralizing antibodies in plasma, the B cell repertoire, and monoclonal antibodies in natural control of acute HBV and how these are affected by HIV. These data could lead to a functional cure for HBV in people with and without HIV.

PI_NAMEs: BAILEY, JUSTIN RICHARD (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acute Hepatitis;acute infection;Adult;Affect;Affinity;Antibodies;Antibody Formation;Antibody Response;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biological Assay;Biological Models;Blood;Cell Culture Techniques;Cell Separation;Characteristics;Chronic;Chronic Hepatitis B;chronic infection;Cirrhosis;co-infection;cohort;Cohort Studies;comparison control;Data;Development;Epitopes;Evolution;follow-up;Frequencies;Hepatitis B;Hepatitis B Antibodies;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;HepG2;HIV;HIV Antibodies;HIV Infections;HIV Seronegativity;HIV-1;Human;human subject;Immune response;Immunocompetent;Immunoglobulin Somatic Hypermutation;In Vitro;Infection;innovation;Knowledge;Length;Maps;Measures;men;Molecular;Monoclonal Antibodies;neutralizing antibody;next generation sequencing;novel;novel strategies;Outcome;Participant;Persons;Plasma;polyclonal antibody;Prevalence;Primary carcinoma of the liver cells;prospective;Recovery;Research;Resources;response;Risk;Role;Sampling;Sorting;Specimen;success;Surface Antigens;System;Techniques;Testing;Time;Translating;Viral;Virus Diseases;Visit

PROJECT_TITLE: Neutralizing antibody responses during natural control of acute hepatitis B with and without HIV-1 coinfection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biomedical Imaging;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Cannabis use is extremely common and associated with clinically-significant negative outcomes for a subset of users, yet it is not currently possible to predict who is at highest risk for cannabis-related harms at the individual level. The current proposal aims to identify a neural network predictive of problem cannabis use, and to characterize the development of this network both before and after cannabis use onset. Elucidating the neural basis of problem cannabis use will facilitate the development of novel prevention and early intervention efforts to mitigate potential cannabis-related harms for individuals at highest risk.

PI_NAMEs: LICHENSTEIN, SARAH D. (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 18 year old;addiction;Adolescence;Adolescent;Adult;Age;alcohol research;Award;Behavior;big-data science;Brain;brain based;brain research;Cannabis;cannabis administration;Child;Clinical;clinically significant;cognitive development;Collection;connectome;connectome based predictive modeling;Corpus striatum structure;Data;Data Analyses;Data Set;design;Development;Early Intervention;early life adversity;endogenous cannabinoid system;Exhibits;Exposure to;Family;Family history of;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;high risk;illicit drug use;improved;Individual;Individual Differences;insight;Intervention;Knowledge;Literature;Longitudinal Studies;Machine Learning;machine learning method;marijuana legalization;marijuana use;Mentorship;Methods;MRI Scans;multimodal neuroimaging;neural;neural network;neurobiological mechanism;neurodevelopment;neuroimaging;neuromechanism;novel;Outcome;Participant;Pattern;peer;Persons;Play;Populations at Risk;predictive modeling;Prevention;preventive intervention;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Risk;Risk Factors;Risk Marker;Role;Sampling;Scanning;Scientist;sex;skills;Specificity;Students;substance use;Time;Training;university student;Validation;Work

PROJECT_TITLE: Connectome-based neuromarkers of problem cannabis use

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Cleft palate with or without cleft lip (CP±L) is among the most common of all congenital conditions, and individuals with CP±L require interdisciplinary care from infancy through adulthood to improve speech, facial appearance, and physical and psychosocial health. However, it remains unknown which children with CP±L are at greatest risk for poor health and psychosocial outcomes, thus inhibiting efforts to develop and provide timely interventions to support health and well-being. This multi-site study will evaluate demographic, medical, and contextual factors associated with psychosocial and health outcomes over time in a large, diverse sample of young children born with CP±L who are enrolled in the Cleft Palate Registry/Research Outcomes Network study, with the goal of advancing clinical care and improving outcomes for this at-risk population.

PI_NAMEs: CRERAND, CANICE ELLEN (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 3 year old;Address;Adult;Affect;Age;Age Months;American;Appearance;Assessment tool;Behavioral;Birth;Body mass index;care outcomes;caregiver stress;Caregivers;Caring;Child;Child Health;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;Clinical;clinical care;cohort;comorbidity;contextual factors;cost;cost estimate;craniofacial;Cross-Sectional Studies;Data;Data Set;Demographic Factors;design;Diagnosis;effective intervention;Emotional;Enrollment;ethnic diversity;Ethnic Origin;evidence base;Exclusion;experience;Face;Family;Family Study;feeding;Future;Geography;Goals;Growth;Health;Health Care Costs;health related quality of life;Hispanic;Impairment;improved;improved outcome;Individual;infancy;Infant;innovation;Insurance;Intervention;Interview;Literature;Longitudinal Studies;Marital Status;Medicaid;Medical;Mental Health;Methodology;Methods;Minority;National Institute of Dental and Craniofacial Research;Operative Surgical Procedures;optimism;orofacial cleft;Outcome;Outcome Measure;Outcomes Research;Palate;palate repair;Perception;Personal Satisfaction;physical conditioning;Populations at Risk;postnatal;Predictive Factor;Problem behavior;prospective;Prospective Studies;protective factors;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Publishing;Quality of life;Race;racial diversity;Recommendation;Registries;Research Personnel;Risk;Risk Factors;Sample Size;Sampling;Services;Single Parent;Site;social;Social Problems;Social support;Speech;Standardization;Stress;Surveys;Time;treatment guidelines;Variant

PROJECT_TITLE: Health and Psychosocial Outcomes in Young Children with Cleft Palate


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

PHR: In this basic research proposal we will investigate how the mechanical forces across epithelial cell-cell junctions and the nucleus regulate the homeostasis of epithelial cells and tissues, including proliferation, migration, barrier function, and three-dimensional organization. A better understanding of these processes will provide insight into epithelial tissue development, homeostasis, and disease. Results from this study have the potential to identify new therapeutic targets for cancer, fibrosis, wound healing, and chronic inflammation.

PI_NAMEs: CONWAY, DANIEL E (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Actomyosin;Adherens Junction;Basic Science;Biosensor;Cell Adhesion;Cell Cycle;cell dimension;Cell Nucleus;Cell Proliferation;cell type;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Chromatin;Chronic;cohesion;Complex;Cytoskeleton;Desmosomes;Development;Disease;Duct (organ) structure;Epithelial Cells;Epithelial Physiology;epithelial to mesenchymal transition;Epithelium;experience;experimental study;Fibrosis;Fluorescence Resonance Energy Transfer;Functional disorder;Goals;Homeostasis;in vitro Model;in vivo;Inflammation;Inflammatory;insight;Intercellular Junctions;Malignant Neoplasms;Measures;mechanical force;Mechanical Stress;Mediator;Mesenchymal Stem Cells;migration;monolayer;Morphogenesis;mouse model;new therapeutic target;Nuclear;Nuclear Lamin;Nuclear Lamina;Nuclear Pore;Nuclear Pore Complex;Organ;Permeability;Process;Proliferating;Proteins;Research;Research Proposals;Role;Sepsis;stem cell differentiation;Structure;Tight Junctions;Tissues;Tube;tumor progression;Work;wound healing

PROJECT_TITLE: Cell junction and nuclear forces as mediators of epithelial cell homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Orphan Drug;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: New medications to treat viral diseases are urgently needed, particularly, for deadly viruses such as Dengue and Zika, which infect tens of millions of people annually. We will develop a new approach for the design of antiviral drugs that can be applied to both Dengue and Zika.

PI_NAMEs: WAGNER, CARSTON R. (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acute;Address;analog;Anhydrides;anti-hepatitis C;Anti-viral Agents;antiviral drug development;arboviral disease;Arboviruses;Australia;Autoimmune Diseases;Binding Proteins;Biodistribution;Biological Availability;Blood;Blood Transfusion;carboxylesterase;Carboxylic Acids;Cells;Cessation of life;Chemicals;Clinical;co-infection;Combined Modality Therapy;COVID-19 treatment;Culicidae;Data;Dengue;Dengue Hemorrhagic Fever;Dengue Infection;Dengue Shock Syndrome;Dengue Virus;design;Development;Disease;Disease Management;dosage;Dose;Drug or chemical Tissue Distribution;Epidemic;esterase;Ethers;European Union;FDA approved;Fever;Hepatitis C Therapy;Hepatitis C virus;Histidine;Hydrolysis;In Vitro;in vivo;interest;Intravenous;intravenous injection;Ions;Japan;Laboratories;Lead;Liver;Liver Circulation;Maternal-Fetal Transmission;Medical;Metabolism;Microcephaly;Modeling;mouse model;novel;novel strategies;nucleoside monophosphate;Nucleosides;Nucleotides;Oral;Periodicity;Permeability;Persons;Pharmaceutical Preparations;Phenols;phosphoramidate;Phosphorus;Plasma;preclinical evaluation;preclinical study;Probability;Process;Prodrugs;remdesivir;Reporting;Ribonucleosides;Ribose;Rodent;Rodent Diseases;SARS-CoV-2 infection;Series;severe COVID-19;Sexual Transmission;success;Sulfhydryl Compounds;Therapeutic;Toxic effect;transmission process;Vaccines;Viral;Viral hepatitis;Viral Physiology;Virus;Virus Diseases;Water;ZIKA;Zika Virus;ZIKV disease;ZIKV infection

PROJECT_TITLE: Anchimerically Activatable Anti-Zika/Dengue ProTides

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Better understanding by researchers and cancer care providers of the unique health needs of sexual and gender minority (SGM) individuals could markedly reduce cancer risk and/or improve experience along the cancer care continuum, from prevention to survivorship. In this project, we will establish and promote a foundational course to help prepare early-career researchers who are developing their research agendas to engage in cancer research relevant to SGM groups. This innovative course will provide an overview of knowledge gaps and challenges in SGM cancer research, strategies and resources to address these issues, and opportunities to network with researchers with shared interests who will serve as role models, mentors, and collaborators, thereby enhancing participants' understanding and abilities to successfully engage in SGM cancer research.

PI_NAMEs: CHANG, SHINE  (contact);SANCHEZ, NELSON FELIX

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: active method;Address;Advisory Committees;Advocacy;Advocate;American Society of Clinical Oncology;anti-cancer research;Area;Award;Awareness;Behavior Therapy;Behavioral Sciences;cancer care;Cancer Control;cancer diagnosis;cancer epidemiology;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;care providers;career;career development;Caring;Clinical;clinical care;Clinical Practice Guideline;Collaborations;Communities;community based participatory approach;comorbidity;Competence;Complement;Comprehensive Cancer Center;Continuity of Patient Care;COVID-19 pandemic;curriculum development;Data Collection;Dedications;design;Disparity;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;Educational workshop;eHealth;Epidemiology;evidence base;Evidence based intervention;experience;Exposure to;Face;Faculty;Fostering;gateway course;gender minority group;gender minority health;gender minority health disparity;gender minority health research;Goals;Health;health equity;Health Personnel;Health Professional;Healthcare;high risk behavior;improved;innovation;Institution;interest;Knowledge;Lead;Leadership;Learning;Malignant Neoplasms;Mentors;mHealth;minority patient;Modality;multidisciplinary;multimodality;Oncology;Outcome;outreach;Participant;patient engagement;Persons;Policies;Population Research;Positioning Attribute;Prevention;Process;Productivity;Professional Organizations;Provider;psychological distress;Publishing;recruit;Research;research and development;Research Methodology;Research Personnel;Resources;response;Risk;Risk Factors;role model;satisfaction;screening;Screening for cancer;Sexual and Gender Minorities;sexual minority group;Shapes;Site;Societies;success;survivorship;Teaching Method;tool;Training;Training and Education;Training Programs;Update

PROJECT_TITLE: Sexual and Gender Minority Cancer Curricular Advances for Research and Education (SGM Cancer CARE)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Chronic Pain;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Patient Safety;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Each year, millions of children experience significant pain and distress surrounding injury-related procedures in the emergency department (ED) and Latinx children may be particularly vulnerable to poor outcomes. This observational, longitudinal cohort study will assess sociocultural, psychological, environmental, and healthcare system factors associated procedural pain and distress and clinical, patient experience, and resource utilization outcome disparities in an ethnically diverse sample of children undergoing invasive injury-related procedures in the ED. Results will direct the development of effective, equitable interventions that reduce procedural pain and improve outcomes surrounding injury-related care in the ED in diverse pediatric populations.

PI_NAMEs: MARTIN, SARAH R (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 9 year old;Accident and Emergency department;Address;Adult;adverse outcome;Affect;Analgesics;Anxiety;Awareness;Behavioral;bone fracture repair;California;care costs;career development;Caring;Child;Child health care;Child Support;Childhood;Client satisfaction;Clinical;Clinical Research;Clinical Sciences;County;Critical Illness;Development;Dimensions;Disparity;Distress;effective therapy;Emergency department visit;Environment;Equity;ethnic disparity;ethnic diversity;Evaluation;experience;Future;General Population;Guidelines;Health;health care disparity;Health Disparities Research;Healthcare Systems;high risk;improved;improved outcome;Injury;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Latinx;Latinx population;Leadership;Length of Stay;Literature;long term recovery;Longitudinal cohort study;Medical;medical schools;Mentors;Mentorship;Methods;minority health;minority health disparity;multidisciplinary;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;Needles;neighborhood disadvantage;Operative Surgical Procedures;Oranges;Outcome;outcome disparities;Pain;Pain management;pain outcome;Patient-Centered Care;Patients;Pattern;pediatric emergency;Pediatric Hospitals;pediatric trauma;Pharmaceutical Preparations;Policies;Population;population health;Populations at Risk;prevent;procedural pain;Procedures;Productivity;professor;programs;Provider;psychologic;psychological outcomes;Recovery;Research;Research Ethics;Research Priority;Resources;Risk;Sampling;satisfaction;social culture;Social Values;sociocultural determinant;Statistical Models;Stress;Training;trait;Translational Research;treatment disparity;United States National Institutes of Health;Universities;Vulnerable Populations;Wait Time;Work

PROJECT_TITLE: Pain in children: clinical, patient experience, and resource utilization outcome disparities surrounding invasive emergency department procedures

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Genetics;Pediatric

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Signaling networks, encoded in genetic networks, underlie the normal development of embryos and can cause developmental abnormalities when disrupted. To cure diseases, we need to understand how genes control signaling networks at multiple scales, and how these networks drive cells to form coherent functional tissues and organs through the process of morphogenesis; this is not simple, as these signaling networks are complex and perturbations at the molecular level propagate in a very complex way to the embryo level. We propose to study how complex genetic and cellular signaling networks function by developing computational and biological models mimicking their behavior, and by probing natural systems with higher-order perturbative tools, hoping to understand their function and logic from subsequent changes at the morphogenetic level.

PI_NAMEs: MORSUT, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Behavior;Biological Models;Cells;Communication;Complex;Computer Models;Congenital Disorders;Defect;Development;Developmental Biology;Developmental Process;Disease;Dissection;Embryo;Embryonic Development;Environment;Event;Extracellular Matrix;Genes;Genetic;Growth;in vivo;insight;Light;Link;Logic;Mesoderm;Microfluidics;Modernization;Molecular;Morphogenesis;notch protein;Optics;optogenetics;Organ;Pathway interactions;Pattern;Periodicals;Population;Process;programs;Proteins;Resolution;reverse genetics;screening;Shapes;Signal Pathway;Signal Transduction;single cell sequencing;Somites;spatiotemporal;spine bone structure;System;Time;Tissues;tool

PROJECT_TITLE: Synthetic development: dissection of morphogenetic programs via reconstructive and perturbative approaches


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative New advances in the field of cancer immunology and genomics have transformed the way people are thinking about the importance of immunotherapy in cancer treatment; a remaining question of current immunotherapy is how the cancer cells and microenviroment immune cells evolve during therapy and how to increase the cancer patient response rate. Here, we propose to use novel single cell/genomics technologies to understand both the changes in cellular circuitry underlying malignancy initiation, progression, and transformation, and also the co- evolving changes in the tumor microenvironment. These aims will be pursued in the context of existing NCI-funded research programs in Translational Immunogenomics Laboratory directed by Dr. Catherine Wu at Dana-Farber Cancer Institute.

PI_NAMEs: LI, SHUQIANG  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Antigens;Biological Assay;cancer cell;cancer genomics;Cancer Patient;cancer therapy;cancer type;Cancer Vaccines;Cells;Dana-Farber Cancer Institute;Dedications;design;Detection;Development;Funding;Generations;genomic platform;Genomics;Genotype;Immune;Immunity;Immunogenomics;Immunotherapy;immunotherapy trials;insight;Investigation;Laboratories;Malignant Neoplasms;Membrane Proteins;Molecular;Monitor;neoplastic cell;novel;novel strategies;Pathway interactions;patient response;Persons;Population;pressure;programs;protein expression;Research;Resources;RNA;Sampling;single cell analysis;single cell genomics;T-cell receptor repertoire;Techniques;Technology;Thinking;transcriptome;transcriptome sequencing;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Single cell investigation of co-evolution in cancer cells and host cell immune microenvironment


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The HEAL Data2Action (D2A) Modeling and Economic Resource Center (MERC) will support the HEAL D2A Innovation Projects by providing expertise in simulation modeling and economic evaluation methods and will consult with the HEAL D2A Innovation Grant recipients on applying these methods and insights in their local implementation activities. The MERC will also conduct original research applying state-of-the-art economic and simulation modeling expertise to understand and address the overdose crisis. The MERC will support the application of health economics and modeling research to real-world decision making about services to prevent or treat opioid use disorder and pain, will further scientific innovation in the field, and will establish a paradigm for integrating health economics and modeling into substance use treatment and prevention policies at the system level.

PI_NAMEs: LINAS, BENJAMIN P.;MCCOLLISTER, KATHRYN E;SCHACKMAN, BRUCE R (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;Adoption;behavioral economics;Caring;Catalogs;chronic pain;Communities;Complex;Consult;Consultations;cost;Cost Analysis;cost outcomes;Costs and Benefits;Coupled;COVID-19 pandemic;Data;data infrastructure;data resource;data sharing;Decision Making;design;disease model;disorder risk;economic evaluation;Economics;Educational workshop;Epidemiology;Evidence based practice;experience;Funding;Grant;Harm Reduction;Health;health application;Health behavior;health care delivery;health care service utilization;health economics;Health Services Research;Health system;Helping to End Addiction Long-term;Hepatitis C virus;HIV;HIV/HCV;implementation intervention;implementation tool;improved;innovation;insight;Institution;Intervention;Investigation;Knowledge;Measurement;Measures;Methodology;Methods;Mission;Modeling;models and simulation;Monitor;National Institute of Drug Abuse;Natural History;novel;opioid use disorder;Outcome;Overdose;overdose prevention;Pain;payment;Persons;Policies;prevent;Prevention;Prevention strategy;Primary Prevention;programs;Province;Qualifying;real world application;Recovery Support;relative cost;Research;Research Personnel;Resources;service delivery;Services;substance use;Substance Use Disorder;substance use treatment;Support System;support tools;System;Techniques;tool;user-friendly;Visualization;Work

PROJECT_TITLE: HEAL Data2Action Modeling and Economic Resource Center


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Baylor Research Education Program in Neurosurgery Narrative The primary goal of this research education program is to provide neurosurgery residents with the opportunity to complete a cohesive, significant research project during their residency training. The program will mentor residents through the entire research process, from project conception to experimental design, data analysis and interpretation, to publication of results and finally to transitioning to a junior faculty position. This hands-on approach is the most effective way to prepare the next generation of young clinician scientists for a productive research career in neurosurgery.

PI_NAMEs: SHETH, SAMEER ANIL (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Basic Science;Cancer Education Grant Program;career;Clinical;Clinical Research;college;Conceptions;Data;Data Analyses;design;Development;Education Projects;education research;Educational Curriculum;empowerment;Ensure;Evaluation;Evidence based practice;experience;Experimental Designs;Faculty;flexibility;Foundations;Funding;Goals;improved;Individual;Institution;K-Series Research Career Programs;Medical center;medical schools;Medicine;Mentors;Mentorship;Motivation;National Institute of Neurological Disorders and Stroke;Neurosciences;Neurosurgeon;neurosurgery;next generation;Oral;Participant;Physicians;Positioning Attribute;Process;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;Residencies;Resources;responsible research conduct;Scientist;Structure;success;Supervision;Talents;Texas;Training;Training Programs;United States National Institutes of Health;Vocational Guidance;Writing


ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative There is a critical need for a new generation of prostate cancer biomarkers capable of accurately detecting aggressive cancers at a localized, curable stage. The overarching goal of this project is to selectively identify those patients with potentially lethal prostate cancers that stand to benefit from early definitive treatment, while preventing unnecessary testing, overdiagnosis, and subsequent overtreatment in the remaining population. To achieve this goal, we have assembled the Michigan-Vanderbilt University Medical Center EDRN Biomarker Characterization Center, which represents a multi-disciplinary team of accomplished academic and industry investigators committed to discovering, developing, and scaling clinical-grade assays for the early detection of aggressive forms of prostate cancer.

PI_NAMEs: CHINNAIYAN, ARUL M (contact);TOSOIAN, JEFFREY JOHN

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Academic Medical Centers;African American population;Alternative Splicing;Biological Assay;Biological Markers;biomarker validation;Biopsy;cancer biomarkers;Cancer Patient;Certification;circular RNA;Clinical;Clinical Treatment;clinically significant;cohort;Collaborations;commercialization;Communities;curative treatments;detection test;Development;Diagnosis;Diagnostic tests;Disease;early detection biomarkers;Early Detection Research Network;Early Diagnosis;ERG gene;Future;Gene Fusion;Generations;Goals;Guidelines;Health;health disparity;improved;Incidence;Indolent;Industry;industry partner;insertion/deletion mutation;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;men;Metastatic Prostate Cancer;Michigan;Minority Enrollment;Minority Groups;Mission;mortality;multidisciplinary;Mutation;New York;next generation;novel;novel diagnostics;novel marker;overtreatment;Pathology;Patients;Performance;personalized risk prediction;Population;Population Heterogeneity;Populations at Risk;prevent;Procedures;Prostate;Prostatic Diseases;PSA screening;Reproduction spores;Research;Research Design;Research Personnel;RNA Splicing;Running;Sampling;Screening for Prostate Cancer;shared decision making;specific biomarkers;Specificity;Standardization;Testing;Texas;Therapeutic Intervention;Time;TMPRSS2 gene;Transcript;transcriptome sequencing;transcriptomics;United States;Universities;Untranslated RNA;urinary;Urine;Validation;Variant;Virginia;Work

PROJECT_TITLE: Michigan-VUMC Biomarker Characterization Center


PI_NAMEs: CHINNAIYAN, ARUL M (contact)

PROJECT_TERMS: Academic Medical Centers;Administrator;Agreement;antigen test;Area;biobank;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biopsy;cancer biomarkers;circular RNA;Clinical;cohort;Collaborations;commercialization;Common Data Element;Communities;curative treatments;Data;Data Analyses;Data Coordinating Center;data sharing;data submission;detection test;Development;Diagnostic tests;Disease;Early Detection Research Network;Early Diagnosis;Ensure;ERG gene;Funding;Future;Gene Fusion;Goals;Guidelines;Health;improved;Industry;industry partner;Informed Consent;insertion/deletion mutation;Institution;Institutional Review Boards;Investigation;Knowledge;Laboratories;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;medical schools;meetings;Methods;Michigan;Mission;Monitor;multidisciplinary;Mutation;Network Infrastructure;next generation;novel;novel diagnostics;novel marker;Occupational activity of managing finances;operation;Pathology;personalized risk prediction;Populations at Risk;Principal Investigator;Procedures;programs;Progress Reports;Prostate;Prostatic Diseases;protocol development;PSA screening;Reporting;Research;Research Personnel;Resources;RNA Splicing;Sampling;screening;Screening for Prostate Cancer;serum PSA;shared decision making;specific biomarkers;Specimen;Standardization;Structure of base of prostate;success;Testing;Texas;TMPRSS2 gene;Transcript;transcriptome sequencing;transcriptomics;Translating;translational goal;Translations;Travel;Universities;University resources;Untranslated RNA;urinary;Urine;Validation;validation studies;Variant;Virginia;Vision;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative The proposed research is relevant to public health in that the discovery of novel models of radiation necrosis is expected to transform our understanding of the damaging effects of radiation and reveal novel avenues for prevention and/or treatment. Thus the proposed studies are relevant to the National Cancer Institute and it’s mission to support research to improve cancer treatment and rehabilitation.

PI_NAMEs: GROSSHANS, DAVID R (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-Dimensional;Adult;Adverse effects;Animal Model;Animals;Apoptosis;Area;Biological;Biological Factors;Biological Markers;Brain;brain cell;Brain Injuries;Brain Neoplasms;brain tissue;cancer cell;cancer rehabilitation;cancer therapy;Cancerous;Cell Death;cell injury;cell type;Cells;Cerebrum;Cessation of life;Characteristics;Childhood;Childhood Ependymoma;Clinical;Clinical Data;clinical practice;clinically relevant;Coculture Techniques;Cognitive;Cognitive deficits;combat;Cranial Irradiation;Data;Dependence;design;disease model;disorder control;Distal;Dose;Educational workshop;Effectiveness;Exposure to;Glioma;high risk;Human;human induced pluripotent stem cells;Image;imaging platform;improved;In Vitro;in vivo;in vivo Model;Incidence;Inflammatory;insight;Intensity modulated proton therapy;Intervention;Investigation;irradiation;Knowledge;Laboratories;Laboratory Study;Linear Energy Transfer;Link;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Medulloblastoma;Mission;Modality;Modeling;Molecular;National Cancer Institute;Necrosis;Necrosis Induction;Normal tissue morphology;novel;Organoids;Outcome;Paralysed;Pathway interactions;Patients;pediatric patients;pharmacologic;Photons;Planning Techniques;pre-clinical;predictive modeling;Preparation;Prevention;Process;proton beam;proton therapy;Protons;Public Health;Radiation;radiation effect;Radiation Injuries;Radiation necrosis;radiation response;radiation risk;Radiation therapy;Relative Biological Effectiveness;Research;Research Support;response;Reverse engineering;Rodent;Roentgen Rays;Role;Scanning;side effect;Signal Transduction;Survivors;Techniques;Tissues;Transgenic Animals;treatment planning;treatment response;Treatment Side Effects;tumor;Uncertainty

PROJECT_TITLE: Characterization of the cellular mechanisms of radiation induced brain necrosis for clinical intervention

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: Academic Medical Centers;Advanced Malignant Neoplasm;African American;Alternative Splicing;American;Biological Assay;Biological Markers;Biological Sciences;biomarker validation;Biopsy;cancer biomarkers;circular RNA;Clinical;clinical development;clinical sequencing;cohort;Collaborations;commercialization;Communities;curative treatments;Data;Death Rate;detection test;Development;Diagnosis;diagnostic biomarker;Diagnostic tests;Disease;DNA;Early Detection Research Network;Early Diagnosis;ERG gene;Expression Profiling;Formalin;fusion gene;Future;Gene Fusion;Guidelines;Health;health care economics;improved;In Situ Hybridization;Incidence;Individual;Industry;industry partner;insertion/deletion mutation;Knowledge;Laboratories;Libraries;Licensing;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;men;Michigan;Minority Groups;Mission;mortality;multidisciplinary;Mutation;New York;novel diagnostics;novel marker;Outcome;overtreatment;Paraffin Embedding;Pathology;personalized predictions;personalized risk prediction;Population;Populations at Risk;precision oncology;Procedures;Productivity;Prognosis;prognostic assays;programs;Prostate;prostate cancer risk;Prostatectomy;Prostatic Diseases;PSA screening;Research;RNA;RNA Splicing;Sampling;Screening for Prostate Cancer;Selection for Treatments;serum PSA;shared decision making;specific biomarkers;Spices;Standardization;success;Testing;Texas;Tissue Embedding;Tissues;TMPRSS2 gene;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;United States;Universities;Untranslated RNA;Urine;Validation;Variant;Virginia;Work

PROJECT_TITLE: Biomarker Developmental Laboratory


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE Organisms are variably sensitive or resistant to oxidative stress, and this is largely determined by differential stability of their proteomes and specialized protein adaptations. This research leverages structural systems biology, proteomics, machine learning, synthetic biology, and molecular and cellular experimentation in E. coli and human cells to elucidate the properties that distinguish protein sensitivity to oxidative stress, identify key protein dysfunctions leading to deleterious cellular phenotypes, and engineer proteins to confer increased robustness to stress. Results from these studies will expand our understanding of fine-resolution protein structure-function relationships, environmental impact on biological systems, and lay a foundation for development of diagnostics and therapeutics for disorders involving oxidative stress.

PI_NAMEs: CHANG, ROGER LARKEN (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 3-Dimensional;Aging;Bacteria;Binding;Biochemical Pathway;Biological Assay;biological systems;Cells;Cellular Stress;Conserved Sequence;Data Analyses;design;Diagnosis;diagnostic development;Disease;Engineering;Environmental Impact;enzyme activity;Escherichia coli;Foundations;Functional disorder;Future;genome-wide;Glyceraldehyde-3-Phosphate Dehydrogenases;Human;human disease;In Vitro;interest;Intervention;Lead;Machine Learning;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Molecular;Molecular and Cellular Biology;molecular modeling;Organism;Outcome;Outer Mitochondrial Membrane;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Phenotype;Property;Protein Engineering;protein function;protein structure;protein structure function;Proteins;Proteome;Proteomics;Radiation Toxicity;rational design;Reactive Oxygen Species;Recombinants;reconstruction;Research;Resistance;Resolution;simulation;Site;Stress;Structure-Activity Relationship;synthetic biology;Systems Biology;Technology;Testing;Theoretical model;Therapeutic;therapeutic development;Variant;Work

PROJECT_TITLE: Structural systems biology of microenvironmental oxidative stress and synthetic biology intervention


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: TOSOIAN, JEFFREY JOHN (contact)

PROJECT_TERMS: Academic Medical Centers;African American;African American population;antigen test;Biological Assay;Biological Markers;biomarker validation;Biopsy;cancer biomarkers;candidate marker;caucasian American;Certification;circular RNA;Clinical;clinical application;clinical diagnostics;clinically significant;cohort;Collaborations;commercialization;Communities;cost;COVID-19;curative treatments;Data;detection test;Development;Diagnosis;diagnostic platform;Diagnostic tests;diagnostic tool;Early Detection Research Network;Early Diagnosis;Early treatment;ERG gene;experience;Foundations;Future;Gene Fusion;Genes;Goals;Guidelines;Health;high risk;improved;Incidence;Industry;industry partner;insertion/deletion mutation;Institution;Laboratories;Laboratory Finding;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;men;Michigan;Mission;Molecular;molecular subtypes;mortality;multidisciplinary;Mutation;New York;next generation sequencing;novel;novel diagnostics;novel marker;Pathology;personalized risk prediction;Population;Populations at Risk;predictive modeling;Procedures;Prostate;Prostate-Specific Antigen;Prostatic Diseases;PSA screening;Quality Control;racial difference;Reproducibility;Research;research clinical testing;Resources;RNA Splicing;Role;Running;Sampling;serum PSA;shared decision making;specific biomarkers;Standardization;success;Testing;Texas;Tissues;TMPRSS2 gene;tool;Training;Transcript;transcriptome sequencing;transcriptomics;Translating;Translations;Underrepresented Populations;Universities;Untranslated RNA;urinary;Urine;Validation;Variant;Virginia;Work

PROJECT_TITLE: Biomarker Reference Laboratory


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BANDOLI, GRETCHEN E. (contact);MARIENFELD, CARLA B

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 14/24 The Healthy Brain & Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT SUMMARY/NARRATIVE Recent evidence from our groups raises the provocative possibility that pancreatic islets of patients with T1D, particularly at early stages of the disease, contain a significant number of ß cells that have lost insulin immunoreactivity. Using a novel technology for quantifying the presence of ß cell DNA (based on ß cell-specific methylation patterns), we have found that the pancreas of patients with T1D is enriched for cells that contain the unmistakable DNA methylation signature of ß cells, yet do not stain for insulin, as well as experiments using a genetically engineered mouse model for interferon-driven islet inflammation suggest that loss of insulin is associated with inflammatory cytokines. We propose to test the hypothesis that empty ß cells, lacking insulin, are present in patients with T1D; to determine the underlying molecular mechanisms; and to search for potential modulators of this response.

PI_NAMEs: SCHATZ, DESMOND ARTHUR (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Acceleration;Agonist;Autoantibodies;autoimmune pathogenesis;Autoimmunity;Automobile Driving;Beta Cell;Biological Assay;Biological Models;Biological Products;Blood Vessels;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Chromogranin A;cytokine;Cytometry;Data;Detection;Diabetes Mellitus;Disease;DNA;DNA Methylation;Down-Regulation;drug candidate;effective intervention;Endocrine;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;Extravasation;Functional disorder;GCG gene;Gene Expression;Genetic Transcription;Genetically Engineered Mouse;Hormones;Human;Hyperglycemia;Image;Immune;Immune system;Immunofluorescence Immunologic;Immunologics;immunoreactivity;improved;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;insight;Insulin;Insulin deficiency;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interferons;islet;Islet Cell;Islets of Langerhans;laser capture microdissection;Lesion;Lobular;Longevity;Lymphatic;Maps;Membrane Glycoproteins;Metabolic;Metabolic Pathway;Methods;Methylation;methylation pattern;mimetics;Modality;Modeling;Molecular;mouse model;Mus;mutant;mutant mouse model;Natural History;new technology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ Donor;Pancreas;Pathway interactions;Patients;Phenotype;Pilot Projects;Play;Process;Production;Proinsulin;Proteins;Quality of life;repository;Residencies;response;Role;Sampling;senescence;Signal Pathway;Signal Transduction;Slice;Stains;STAT5B gene;System;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutic evaluation;therapeutic target;Tissues;trafficking;transcriptome sequencing;type I and type II diabetes;WFS1 gene

PROJECT_TITLE: Survival and potential of insulin-deficient beta cells in type 1 diabetes


NIH_SPENDING_CATS: Biotechnology;Cancer;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Papillomaviruses cause medically important benign tumors in the nose, throat, genitalia, and eyes. The virus produces E6 and E7 oncoproteins that cause the tumors. This application has identified a new cellular target of the viral E6 oncoprotein common to both benign and malignant virus types.

PI_NAMEs: VANDE POL, SCOTT BRIAN (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adaptor Signaling Protein;Adrenergic Agents;Animals;Benign;Binding;Biological Assay;Biology;Cell Proliferation;Cells;cellular targeting;Cervical;comparative;Complex;Cutaneous;Data;derepression;Disease;Dissection;Distant;Epithelial Cells;Epithelioma;Eye;G-Protein-Coupled Receptors;Genetic;Genitalia;Goals;high risk;Human Papillomavirus;insight;keratinocyte;knock-down;Life;Life Cycle Stages;Location;Low risk HPV;Malignant - descriptor;Malignant Neoplasms;Measures;Medical;medical complication;Modality;model organism;mutant;Mutate;Normal Cell;Nose;novel;Oncogenic;Oncoproteins;Papilloma;Papillomavirus;Pathway interactions;PDZ protein;penis foreskin;Peptides;Pharyngeal structure;Process;Production;protein expression;Proteins;recruit;Recurrent respiratory papillomatosis;Risk;Role;Signal Pathway;Signal Transduction;Site;sodium-hydrogen exchanger regulatory factor;Squamous Cell Papillomas;Structure;Surface;Testing;Time;Tissues;TP53 gene;trait;transcription factor;tumor;tumorigenesis;UBE3A gene;ubiquitin ligase;Viral;Virus;WNT Signaling Pathway

PROJECT_TITLE: Papillomavirus E6 cellular targets

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The material properties of subcellular structures are inextricably connected with their biological functions, just as the material properties of blood and bone underlie their distinct physiological functions. The purpose of this research is to discover what protein sequence features and molecular interactions determine the material properties of a class of intracellular compartments called membraneless organelles, which can be liquid-like, gel- like, or a combination thereof. Our vision is to understand how the material properties of membraneless organelles underlie their normal biological functions and their contributions to neurodegeneration and other disease processes.

PI_NAMEs: SCHUSTER, BENJAMIN S (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Amino Acid Sequence;Binding;biological adaptation to stress;Biological Process;Biology;biophysical techniques;Biophysics;Biotechnology;Blood;bone;Cell Nucleolus;Cell Physiology;Cytoplasmic Granules;Development;Disease;Foundations;Gel;Gene Expression Regulation;Germ;Goals;Health;Link;Liquid substance;Measures;Membrane;Microscopy;Molecular;Mutagenesis;nanoparticle;Nanotechnology;Nerve Degeneration;Organelles;Pathology;Phase;Phase Transition;Physical condensation;Physiological;Process;Property;Protein Engineering;Proteins;Research;Rheology;Role;Solid;stress granule;Subcellular structure;targeted treatment;Toxic effect;Veins;Vision;Work

PROJECT_TITLE: Sequence determinants of membraneless organelle rheology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cardiovascular;Genetics;Heart Disease;Human Genome;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVES Although recent developments in anti-cancer treatments have improved cancer patients’ outcome, a significant number of cancer survivors are now suffering from heart failure that is caused by cancer treatments as adverse side effects. Doxorubicin, one of the most common chemotherapy drugs, is well known for its cardiotoxicity, but currently it is still difficult to predict who will develop doxorubicin-induced cardiotoxicity (DIC) and to prevent it. Here, we will make a platform to develop “cardioprotective” therapy against DIC using 3D cardiac microtissues as a surrogate to mimic patients’ hearts, which will significantly improve the risk assessment and risk reduction of DIC, and furthermore can be applied to other cancer treatment-related cardiotoxicities.

PI_NAMEs: RAJADAS, JAYAKUMAR ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Adherent Culture;African American;Anthracycline;anti-cancer treatment;Asian;Bar Codes;Biocompatible Materials;Bioinformatics;Biomedical Engineering;Breast Cancer Patient;Cancer Etiology;Cancer Patient;Cancer Survivor;cancer therapy;Candidate Disease Gene;candidate selection;candidate validation;Cardiac;Cardiac Myocytes;cardioprotection;Cardiotoxicity;Caucasians;Cell Communication;Cell Line;Cells;checkpoint therapy;Chemicals;chemotherapy;Clinic;Clinical;Clinical Oncology;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;CRISPR/Cas technology;Data;Development;Developmental Biology;Doxorubicin;drug candidate;Drug Delivery Systems;drug repurposing;drug use screening;Drug Utilization;endonuclease;Endothelial Cells;Engineering;ethnic diversity;experience;Feedback;Fibroblasts;Gene Targeting;Genes;genome-wide;Genomics;Goals;Guide RNA;Heart;Heart failure;high throughput screening;Hispanic;Human;human induced pluripotent stem cells;Immunotherapy;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;inhibitor therapy;Libraries;Malignant Neoplasms;Modeling;nanoparticle;Nanotechnology;Oncology;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;prevent;protective effect;Qi;Radiation therapy;recruit;Research;Resistance;Risk Assessment;Risk Reduction;RNA library;screening;side effect;Signal Transduction;stem cell biology;Technology;Testing;therapeutic candidate;therapeutic target;Tissues;Treatment Efficacy;Treatment-Related Cancer;Tungsten;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Cardioprotective Therapy for Doxorubicin Using iPSC Microtissue and CRISPR Screening

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Clinical Research;Data Science;Kidney Disease;Precision Medicine

PHR: LAY SUMMARY The overarching objective of the Kidney Mapping Atlas Project (KMAP) is to create and support the central data management, integration and dissemination platform for the Kidney Precision Medicine Project (KPMP). Our focus for KMAP will be centered around the key values established by us in the first funding cycle of KPMP: a collaborative environment committed to promoting participant safety and engagement, scientific rigor, and outreach to the global renal research community anchored in a concept of interdisciplinary team science necessary to drive disruptive advances in kidney precision medicine. For the second funding cycle our assembled team across ten leading US research institutions has expertise in 15 distinct knowledge domains to continue our uncompromising commitment to our patient partners co-leading our efforts to transform kidney disease research.

PI_NAMEs: HIMMELFARB, JONATHAN ;KRETZLER, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Anatomy;Atlases;Bioinformatics;Biometry;Biopsy;Cells;Chronic Kidney Failure;Clinical;cloud based;Collaborations;collaborative environment;Communities;Community Outreach;computerized data processing;Data;Data Analyses;data curation;Data Display;data dissemination;data integration;data management;data modeling;Data Set;Data Storage and Retrieval;data visualization;design;digital pathology;Dimensions;Disease;disorder subtype;Ecosystem;Ensure;Environment;equity, diversity, and inclusion;experience;FAIR principles;flexibility;Funding;Future;Generations;genomic data;Goals;Health;Human BioMolecular Atlas Program;indexing;Institution;interstitial;Joints;Kidney;Kidney Diseases;Knowledge;Lead;Leadership;Maps;Metadata;Michigan;Molecular;multimodal data;multimodality;nephrogenesis;Nephrology;new therapeutic target;Ontology;outreach;Participant;participant safety;Pathologist;Pathology;Pathway interactions;patient engagement;Patients;Phase;Philosophy;precision medicine;Process;Quality Control;recruit;Research;Research Personnel;research study;response;Risk;Role;Science;Services;Site;skills;social;software development;Stratification;Structure;structured data;Students;success;System;Systems Biology;Tissue atlas;Tissues;tool;Universities;Washington;website development

PROJECT_TITLE: KPMP Kidney Mapping and Atlas Project (KMAP)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: NARRATIVE Each adult human harbors hundreds of bacterial species in their intestine, but it is not clear how these species evolve competitive or cooperative relationships with one another, given the rapid and frequent mixing and redistribution of intestinal contents. We propose that bacteria adhere to certain types of food particles, and that this allows bacterial cells of different species to have sustained interactions with their co-adherent neighbors. We are using orally administered artificial food particles to uncover the bacterial genes required for this process and to generate a map of interacting bacterial species in the intestine.

PI_NAMEs: PATNODE, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Adhesions;Adult;Bacteria;Bacterial Adhesion;Bacterial Genes;Bacteroidetes;Binding;Cell Wall;Cells;Communicable Diseases;dietary;Exclusion;Family;Food;Generations;Gnotobiotic;gut microbes;gut microbiota;Heterogeneity;Immune System Diseases;in vivo;Intestinal Content;Intestines;Label;Libraries;Library Administration;magnetic beads;Maps;Measures;member;Metabolic Diseases;Microbe;microbial;microbial community;Mus;Mutagenesis;Mutation;Mutation Analysis;Oral Administration;particle;Phenotype;Plants;Polysaccharides;Positioning Attribute;prevent;Process;Proteins;Site;Specificity;Structure;Technology;Time

PROJECT_TITLE: Spatially Organized Bacterial Interaction Networks in the Gut Microbiota

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Comparative Effectiveness Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Sepsis

PHR: PROJECT NARRATIVE Combining a novel causal inference method with several statistical and machine-learning techniques, this New Innovator Award will develop and test a new study design for determining the causal effects of clinical interventions for sepsis in large-scale electronic health record data. If successful, this project will equip clinical sepsis researchers with a tool that uses a fundamentally different approach to causal effect estimation than current state-of-the-art methods, to reliably determine the effectiveness of clinical interventions for sepsis in routine care. This study design would constitute an important step towards providing more individualized care for sepsis because it would allow clinical researchers to take advantage of the large size of electronic health record data to establish how the effectiveness of different interventions for sepsis varies across highly granular patient subgroups defined by various combinations of sociodemographic and clinical characteristics.

PI_NAMEs: GELDSETZER, PASCAL  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Affect;age group;Area;Award;Caring;Cessation of life;Characteristics;Clinical;clinical care;clinical effect;Clinical effectiveness;Clinical Medicine;Clinical Research;Clinical Trials;comorbidity;Complement;Complex;Confounding Factors (Epidemiology);Data;Data Set;Diagnosis;Disadvantaged;Effectiveness;effectiveness evaluation;Electronic Health Record;Erythrocyte Transfusion;Exercise;feasibility testing;Foundations;Guidelines;health care settings;Hemoglobin;Heterogeneity;Household;improved;innovation;Intensive Care Units;interest;Intervention;intervention effect;Life;Machine Learning;Measurement;Measures;Medicine;method development;Methodology;Methods;Monitor;Nature;novel;novel strategies;Observational Study;Outcome;patient subsets;Patients;personalized care;population health;Postdoctoral Fellow;pressure;Probability;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Design;Research Personnel;routine care;screening;Sepsis;septic patients;Series;simulation;sociodemographics;statistical and machine learning;statistical learning;Subgroup;Surveys;Techniques;Testing;tool;treatment as usual;treatment effect;Uncertainty;United States;virtual;Work

PROJECT_TITLE: The impact of clinical interventions for sepsis in routine care and among detailed patient subgroups: A novel approach for causal effect estimation in electronic health record data


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: MIAMI

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE The enclosed new application is in response to NOT-DA-20-013 and will evaluate the drug-drug interactions among opioid abuse (morphine), medications to treat opioid use disorders (naltrexone), and medications for HIV prevention (Cabotegravir). Pharmacokinetic, pharmacodynamic, and toxicological interactions among the three classes of pharmaceuticals will be studied using mouse models and non-human primate systems.

PI_NAMEs: BUCH, SHILPA J.;EL-HAGE, NAZIRA  (contact);FLETCHER, COURTNEY V

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: absorption;Address;Adherence;AIDS prevention;Anti-Retroviral Agents;Antibodies;antinociception;antiretroviral therapy;aqueous;attenuation;Autopsy;Biological Availability;Biological Process;Blood;Blood Chemical Analysis;Blood specimen;Brain;CD34 gene;chronic pain;Clinical;comorbidity;Computer software;cost effective;Coupled;Data;Dose;drug clearance;Drug Interactions;Drug Kinetics;drug metabolism;Drug Regulations;Drug toxicity;Drug user;Enzyme-Linked Immunosorbent Assay;Enzymes;Epigenetic Process;epigenetic variation;Excretory function;Exhibits;experimental study;Failure;Fatigue;Feces;Female;Glucuronosyltransferase;Goals;Half-Life;Hepatotoxicity;Heroin;high risk;Histology;Histones;HIV;HIV Infections;humanized mouse;Illicit Drugs;Imaging Techniques;Immunohistochemistry;Inbred BALB C Mice;Individual;Infection;Inflammatory;inhibitor;Injections;insight;Integrase;ion mobility;Knowledge;liquid chromatography mass spectrometry;Macaca mulatta;male;Mass Spectrum Analysis;Measures;melting;Membrane;Metabolism;Modeling;Morphine;Morphology;mouse model;mRNA Expression;mu opioid receptors;Mus;Mutation;Naltrexone;nano;nephrotoxicity;nociceptive response;nonhuman primate;novel;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid misuse;Opioid Receptor;opioid use disorder;Oral;Pain management;Pain Measurement;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Plasma;Populations at Risk;prescription opioid;prescription opioid misuse;Prevention;Property;Prophylactic treatment;Publications;Publishing;Regimen;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Saline;Solubility;Substance Use Disorder;Suspensions;synergism;System;Tail;Testing;The Jackson Laboratory;Tissues;Toxic effect;Toxicology;United States;United States Food and Drug Administration;Uridine Diphosphate;Urine;Variant;Viral;Viral Load result;Western Blotting

PROJECT_TITLE: Title: Pharmacokinetic, pharmacodynamic , and toxicological interactions among  Opioids and Cabotegravir

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Macrophages and fibroblasts participate in many inflammatory processes that drive the development of human disease, such as inflammatory bowel diseases, fibrosis and cancer. We will employ a powerful bottom-up approach that reconstitutes the communication and interaction between macrophages and fibroblasts, to discovery how these two cell types impact immune functions collectively during tissue homeostasis and inflammation. This proposal aims to uncover the basic mechanisms of how macrophages function in tissues, which may ultimately allow us to program immune interactions to restore tissue homeostasis from disease.

PI_NAMEs: ZHOU, XU  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: base;Cell Communication;Cell Physiology;cell type;Cells;Cellular biology;chemical genetics;Communication;Communities;Data;Development;Disease;Fibroblasts;Fibrosis;genetic approach;Goals;Growth Factor;Homeostasis;human disease;Image;Immune;immune function;Immune response;Immunology;Immunology procedure;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;Knowledge;Label;Macrophage;Malignant Neoplasms;Methods;Molecular;Nature;Paracrine Communication;Population;Process;programs;Publishing;Reagent;receptor;reconstitution;Research;response;self assembly;Stromal Cells;System;Technology;therapeutic target;Tissues;tool;transcriptomic profiling;Vision

PROJECT_TITLE: Understanding Immune-Stromal Interactions in Tissue Homeostasis and Inflammation


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative The proposed study will test the effectiveness of our youth-designed, community-based intervention to address barriers to PrEP use faced by adolescent girls and young women in inequitable relationships and subject to intimate partner violence in Kenya. Combined with critical process data, these findings will fill a gap in the limited evidence base for interventions to expand PrEP uptake and adherence in this priority population and facilitate rapid translation from research to practice.

PI_NAMEs: ROBERTS, SARAH TYLER (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adherence;Affect;Africa South of the Sahara;African Women;Age;AIDS prevention;arm;Blood;Clinical Trials;Collaborations;Communities;community intervention;contextual factors;Country;County;Couples;Data;design;Diphosphates;Dryness;Education;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness trial;empowerment;Enrollment;Ensure;Event;evidence base;Evidence based intervention;experience;Female Adolescents;follow-up;Future;Gender;girls;Goals;Health;HIV;HIV Infections;implementation evaluation;implementation intervention;implementation process;Incidence;Individual;Inequality;Inequity;Infrastructure;Intervention;intervention effect;Interview;intimate partner violence;Kenya;male;Measures;Methods;Modeling;Oral;Outcome;Participant;Policies;Population;Positioning Attribute;post intervention;pragmatic study;pre-exposure prophylaxis;Prevalence;prevention service;preventive intervention;primary outcome;Process;process evaluation;prospective;Provider;provider intervention;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Reporting;research and development;Research Design;Research Personnel;research to practice;response;Risk;scale up;secondary outcome;Self Efficacy;Services;Severities;Site;social stigma;Spottings;Tenofovir;Testing;theories;therapy design;therapy development;Translational Research;treatment arm;uptake;ward;Woman;Work;young woman;Youth

PROJECT_TITLE: Tu'Washindi: A relationship-focused intervention to reduce GBV and increase PrEP uptake and adherence among Kenyan AGYW

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Nutrition;Obesity;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  We have developed a high-resolution, moment-to-moment assessment that quantifies vascular sensitivity to the sympathetic nervous system, which becomes highly dysfunctional in obesity-related hypertension. By comprehensively examining the role of hyperglycemia and hyperlipidemia on vascular function, and the extent to which pharmacological reductions in sympathetic nerve activity mitigate the pro-inflammatory phenotype of obesity, we will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the high prevalence of hypertension and cardiovascular disease in this population.

PI_NAMEs: HOLWERDA, SETH WILLIAM (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acceleration;adult obesity;Apoptosis;Ascorbic Acid;Attenuated;Blood Pressure;blood pressure reduction;blood pressure variability;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Chronic;Clinical;Clinical Research;Clonidine;COVID-19 patient;cytokine;Data;design;Development;Diuretics;Double-Blind Method;Dyslipidemias;effective therapy;Endothelial Cells;Glucose;glucose uptake;Goals;High Prevalence;Human;Hydrochlorothiazide;Hyperglycemia;Hyperinsulinism;Hyperlipidemia;Hypertension;Impairment;Individual;Inflammation;Inflammatory;inflammatory marker;Infusion procedures;innovation;insight;Insulin;Insulin Resistance;Interleukin-6;Intravenous infusion procedures;Lipids;Macrophage;Measures;Mediating;mortality;Muscle;Nerve;Norepinephrine;novel;novel strategies;novel therapeutic intervention;Obesity;obesity development;Obesity Related Hypertension;Oral;Outcome;Overweight;Oxidative Stress;Participant;pharmacologic;Phenotype;Pilot Projects;Placebo Control;Placebos;Population;post SARS-CoV-2 infection;Prospective Studies;Quality of life;Randomized;Reactive Oxygen Species;Research;Research Design;Resolution;response;Risk;Risk Factors;Role;Serum;Smooth Muscle Myocytes;Source;Sympathetic Nervous System;Testing;Thinness;TNF gene;translational study;Vascular Diseases;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;vasoconstriction

PROJECT_TITLE: Sympathetic-Vascular Dysfunction in Obesity-Related Hypertension

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ORG_CITY: Rockville

ORG_NAME: SOCIETY FOR DEVELOPMENTAL BIOLOGY

PHR: Unguez, G PROJECT NARRATIVE Choose Development! is the Society for Developmental Biology’s program to provide under- represented undergraduate students a research-intensive experience for two summers to complement their formal collegial education. Through continuous multilevel mentorship, hands- on laboratory experimentations, results presentation and meetings with leaders in the field the students will acquire knowledge, confidence and science identity. These approaches will contribute to broadening participation and retention of currently underrepresented populations in research areas of interest to the National Institute of Child Health and Human Development such as developmental, stem cell and regenerative biology, gene network and biomechanics in development.

PI_NAMEs: UNGUEZ, GRACIELA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Area;Atmosphere;Awareness;Biomechanics;broadening participation research;career;Cell Reprogramming;Cells;Communities;Complement;Computer Analysis;Development;Developmental Biology;disability;Disease;Doctor of Philosophy;Economically Deprived Population;Education;Etiology;Event;experience;Faculty;gene network;gene regulatory network;Goals;graduate school;graduate student;hands on research;Immersion;Infrastructure;Institution;interest;Knowledge acquisition;laboratory experiment;Laboratory Research;Laboratory Study;Leadership;literate;Manuscripts;medical schools;meetings;member;Mentors;Mentorship;Morphogenesis;National Institute of Child Health and Human Development;nuclear reprogramming;Organ;Organism;Organogenesis;Outcome;Participant;Positioning Attribute;Postdoctoral Fellow;Preparation;programs;Publications;regenerative biology;Research;role model;Science;Societies;socioeconomic disadvantage;stem cell biology;stem cells;student mentoring;Students;Systems Biology;Tissues;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Whole Organism

PROJECT_TITLE: Choose Development! to broaden participation of underrepresented undergraduates in developmental biology research

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ORG_CITY: NEW HAVEN

ORG_NAME: TEZCAT LABORATORIES LLC

PHR: Project Narrative: Tezcat Biosciences is an early-stage biotechnology company focused on developing innovative therapeutics to treat mutant RAS cancers. In this Phase II SBIR, Tezcat is further developing a proprietary monobody-MMAE conjugate for treatment of multiple myeloma.

PI_NAMEs: RAMIREZ, CRAIG PATRICK (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: acute toxicity;Affect;Affinity;Agreement;Animals;Antibodies;assay development;Binding Proteins;Biological;Biological Assay;Biological Products;Biological Sciences;biopharmaceutical industry;Biotechnology;cancer cell;Cell Line;Cell model;cell type;Cells;Characteristics;Clinic;Clinical Research;Clinical Trials;commercialization;cytotoxic;cytotoxicity;Development;Development Plans;Dose;drug candidate;Drug Delivery Systems;Drug Kinetics;Enzyme-Linked Immunosorbent Assay;Equus caballus;expectation;Extracellular Fluid;Extracellular Protein;FDA approved;Fibronectins;first-in-human;Future;Health;Hematologic Neoplasms;Human;in vivo;Incidence;Incubated;innovation;Lead;Licensing;liquid chromatography mass spectrometry;Liquid substance;Malignant Neoplasms;manufacture;meetings;Metabolic;method development;Methods;Morbidity - disease rate;mortality;Multiple Myeloma;mutant;Mutation;neoplastic cell;nonhuman primate;Normal Cell;novel;Nutrient;Patients;Penetration;Pharmaceutical Preparations;Phase;pre-clinical;pre-Investigational New Drug meeting;Process;programs;Proteasome Inhibitor;Proteins;Protocols documentation;Qualifying;RAS driven cancer;ras Oncogene;Rattus;Refractory;Relapse;relapse patients;Research Design;Research Personnel;Resistance;Resources;response;Rights;Risk;Safety;safety study;Serum;Shapes;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Solubility;solute;Sprague-Dawley Rats;success;Technology;Testing;Therapeutic;therapeutic development;therapeutically effective;Tissues;Toxic effect;Toxicology;tumor;uptake;Validation;Writing;Xenograft Model

PROJECT_TITLE: A novel monobody-drug conjugate to treat mutant Ras multiple myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(12)B]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative The intestine exerts the important function of maximizing nutrient uptake from the diet ingested during feeding periods. Maintenance of intestinal health requires the precise regulation of local immune responses against microbes and dietary components. However, there is a major gap in our understanding of how dietary-derived signals affect intestinal immune responses during feeding. Gut neurons have emerged as important regulators of intestinal immune responses, since they interact with immune cells and are quickly activated by the presence of food in the intestine. Our studies of how diet modulates gut neurons that control intestinal immunity are expected to uncover dietary and neuronal therapeutic targets to gut disturbances associated with dysregulation in immune responses, namely intestinal infections and inflammatory bowel disease.

PI_NAMEs: TALBOT, JHIMMY  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: absorption;Advanced Development;Affect;Animals;Area;Autonomic nervous system;Behavior;Biochemical;Biological;Biological Assay;Calcium;calcium indicator;Cell Physiology;Cells;Central Nervous System;circadian;clinically relevant;commensal microbes;Communicable Diseases;Complex;Computer Analysis;CRISPR/Cas technology;Detection;Development;Diet;Diet Modification;dietary;Dietary Component;dietary control;Dietary Fats;Dietary intake;Disease;Diurnal Rhythm;Eating;Engineering;Enteral;enteric infection;Enteric Nervous System;enteric pathogen;Fatty acid glycerol esters;feeding;Food;food consumption;Functional disorder;gastrointestinal;Genetic;genetic manipulation;Goals;Health;Homeostasis;Host Defense;host microbiota;Host resistance;Immune;Immune response;Immune system;Immunity;improved;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;Ingestion;innovation;insight;interest;intestinal barrier;Intestinal Content;Intestines;intravital imaging;Invaded;Irritable Bowel Syndrome;Knowledge;Lymphoid Cell;Maintenance;Measures;Mediating;Microbe;microbial;microorganism;Molecular;Molecular Profiling;mouse model;Nature;Neuroimmune;neuroimmunology;neuronal circuitry;Neurons;Nutrient;Nutritional;Pathway interactions;Physiological;Positioning Attribute;Predisposition;prevent;Proteins;Regulation;Reporter;Resistance to infection;response;Sensory;Signal Transduction;single cell genomics;Source;success;Technology;Therapeutic;therapeutic target;Time;tool;transmission process;uptake;Vasoactive Intestinal Peptide;Viral

PROJECT_TITLE: Mechanism of modulation of intestinal immune responses by dietary signals


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Risk-based cancer screening seeks to maximize the benefits and minimize the harms of screening, and to achieve these goals, cancer risk prediction models need to be translated into risk assessment tools that are meaningful and useful for the public and in clinical practice. However, a critical barrier to implementing risk- based screening is that many people reject that their risk estimate is true for them personally. Therefore, our goal is to understand the reasons for risk rejection, and identify methods for communicating personalized risk information that people can both understand and accept.

PI_NAMEs: SCHERER, LAURA D. (contact);WATERS, ERIKA A

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Affect;Age;American Cancer Society;Area;Assessment tool;Behavior;Behavioral;Breast Cancer Detection;Breast Cancer Risk Factor;Cancer Control;cancer risk;Cardiovascular Diseases;clinical application;clinical practice;cognitive interview;Colon;Communication;Communication Methods;Communities;Comprehension;Decision Making;Demographic Factors;Development;Diagnosis;Disease;distrust;Evaluation;experimental study;Family history of;Feedback;Fostering;Future;Goals;Guidelines;Harm Reduction;Health;Health Services;high risk;High Risk Woman;improved;Individual;individual patient;information seeking behavior;Interview;Knowledge;Longitudinal Studies;Longitudinal Surveys;Lung;Maintenance;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Medical History;Medicine;Nature;Outcome;Patient Care;patient screening;Patients;Persons;precision cancer prevention;precision medicine;precision oncology;Prevention;Preventive Medicine;Process;Process Assessment;Prostate;psychologic;Psychological Factors;Race;Randomized;Recommendation;Research;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Marker;risk minimization;risk prediction model;Risk Reduction;risk stratification;Sampling;Science;screening;Screening for cancer;screening guidelines;Surveys;tailored health care;Testing;theories;Translating;United States Preventative Services Task Force;Woman;Work

PROJECT_TITLE: Understanding and addressing rejection of personalized cancer risk information

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Cancer Genomics;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Radiation Oncology

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this proposal is to identify and study relevant patterns of post-irradiation morbidity and mortality in a controlled, well-defined NHP population, by collaborating and sharing data with qualified investigators. Data sharing and administrative oversight are designed to maximize use of the resource. The program will identify patterns of post-irradiation morbidity; identify characteristics of animals with differing radiation-induced disorders; assess late effects of prior mitigator treatment; and refine the cohort to balance age, sex, dose, and mitigator type.

PI_NAMEs: CLINE, J. MARK (contact)

PROGRAM_OFFICER_NAME: DICARLO-COHEN, ANDREA L

PROJECT_TERMS: Acute;Adolescent;Adult;Adverse effects;Age;Animals;Antibiotics;Atrophic;Autopsy;Biological Markers;Blood;Body Fluids;Bone Marrow;Brain;cancer therapy;Cardiac;Cataract;Characteristics;Chronic diarrhea;Chronic Kidney Failure;Clinical;clinical examination;Clinical Pathology;cohort;Collaborations;Communities;comorbidity;Data;Data Set;data sharing;design;Diabetes Mellitus;Disease;Distant;Dose;Epithelium;Equilibrium;exome sequencing;Failure;Female;Fibrosis;Functional disorder;Funding;Gastrointestinal Diseases;Gene Expression;Genes;Genetic;Genetic Markers;Genomics;Goals;Growth;Hematopoietic;Hematopoietic Cell Growth Factors;Hematopoietic Neoplasms;Human;Image;Immune;Immunophenotyping;Impaired cognition;Impairment;improved;Incidence;Inflammatory;inflammatory marker;Institution;interest;Interleukin-6;irradiation;Knowledge;Late Effects;Lesion;Long-Term Effects;Macaca mulatta;Macrophage;Magnetic Resonance Imaging;male;Measurement;Measures;Medical emergency;Mesenchymal Cell Neoplasm;Metabolic;Metabolic Diseases;microbiome;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Myocardial;Neoplasms;Nervous System Disorder;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Organ;Outcome;outreach;Pathology;Pathway interactions;Pattern;Phenotype;Phylogenetic Analysis;Population;programs;protective effect;Qualifying;Radiation;radiation adverse effect;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigator;radiation resistance;Recovery;Research Personnel;Resistance;Resources;response;Rodent;Sampling;Sarcoma;sex;Source;Supportive care;Survivors;Systemic disease;Time;Tissues;trait;Transforming Growth Factor beta;ultrasound;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: The Wake Forest Nonhuman Primate Radiation Survivor Cohort