NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Expanding access to take home naloxone, a medication used to reverse an opioid overdose death, is a critical step in ensuring equity in available evidence-based practices to address the opioid epidemic. The proposed research will contribute to advancement of implementation strategies focused on equity and sustainability, by addressing the contextual needs of underserved communities through refinement of evidence-based programs. This proposal aligns closely with NIDA’s strategic goal to “increase strategic partnership with the community to improve dissemination and implementation of evidence-based research findings into policy and practice.”

PI_NAMEs: WAGNER, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adoption;Adverse event;Australia;Awareness;built environment;career;career development;Communities;community partners;cost;COVID-19 pandemic;Data;design;Development Plans;Disparity;Dissemination and Implementation;effective intervention;Effectiveness;Ensure;Epidemic;Equity;Europe;Evaluation;Event;evidence base;Evidence based practice;Evidence based program;experience;Funding;Future;Geography;Goals;Harm Reduction;Health system;high risk;Home;implementation barriers;implementation cost;implementation strategy;improved;Individual;innovation;interest;Intervention;Interview;Life;Location;low socioeconomic status;Maintenance;member;Mentors;Modeling;Naloxone;naloxone dispensing;National Institute of Drug Abuse;Needle-Exchange Programs;Opioid Antagonist;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid user;Outcome;overdose death;Overdose reduction;Overdose reversal;Pharmaceutical Preparations;Physical environment;Policies;Population;Populations at Risk;Practical Robust Implementation and Sustainability Model;pragmatic randomized trial;pragmatic trial;Privacy;programs;Public Health;Qualitative Evaluations;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Project Grants;Resource-limited setting;Risk;Rural;Rural Community;Safety;Secure;Services;skills;Social Environment;substance use;Surveys;Target Populations;Testing;tool;Training;underserved community;Underserved Population;United States;uptake;Urban Community;usability;user centered design;Work;young adult

PROJECT_TITLE: Vending machine Naloxone Distribution for Your community (VENDY):  Increasing reach and implementation of naloxone distribution

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This research project challenges the current concept of age-related macular degeneration (AMD), the leading cause of severe vision loss in the developed world. Demonstrating that a specific neovascular subtype of AMD actually prevents disease progression in the sense of an intrinsic “rescue mechanism” would not only provide essential information for currently tested treatment approaches but also provide a rationale for new therapeutic strategies in AMD to prevent vision loss.

PI_NAMEs: FLECKENSTEIN, MONIKA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age related macular degeneration;Angiography;Area;Artificial Intelligence;Biological;Biological Markers;Biological Products;Blindness;Clinical;Clinical Research;cohort;Consumption;Data;data integration;Data Set;Development;Dimensions;Disease Progression;Event;Excision;Exhibits;Exudate;Exudative age-related macular degeneration;Eye;Fibrosis;Fundus;Future;Goals;improved;in vivo;Intervention;Letters;macula;Membrane;Morphology;neovascular;neovascularization;Non-Invasive Detection;Nonexudative age-related macular degeneration;novel therapeutic intervention;Optical Coherence Tomography;Pathologist;Patients;Perimetry;personalized medicine;photoreceptor degeneration;Photoreceptors;predictive modeling;preservation;prevent;Procedures;Process;professor;Prognosis;Property;prospective;protective effect;Protocols documentation;Research Personnel;Research Project Grants;Resolution;response;Retina;retinal imaging;Role;Structure;Structure of retinal pigment epithelium;supervised learning;Testing;Therapeutic;Thinking;Time;Tissues;Vascular Endothelial Growth Factors;Vision;Visualization

PROJECT_TITLE: The Impact of Non-Exudative Type 1 Macular Neovascularization (MNV) on Age-related Macular Degeneration (AMD) Progression

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: DAVIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: The proposed research is relevant to public health because 10% of all infants worldwide are born prematurely, and these infants are especially susceptible to bacterial infection, inflammation and, ultimately, tissue injury that can lead to death. The proposed study opens a new line of investigation focused on the role of maternal inflammation in the high susceptibility of premature infants to intestinal injury. Thus, the proposed experiments are relevant to the NIH mission of developing fundamental knowledge that will help to protect and improve human health by deepening our understanding of the processes of human growth and development.

PI_NAMEs: MCELROY, STEVEN JAMES (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;Address;adverse outcome;Bacteria;Bacterial Infections;Beds;Biology;Body System;Cell Density;Cell Differentiation process;Cell Physiology;Cellular biology;Cellular Morphology;Cessation of life;Chronic;clinically relevant;conditional knockout;Critical Pathways;cytokine;Data;density;Development;Event;experimental study;Exposure to;Family member;fetal;Fetus;Functional disorder;Genetic;Goals;Growth and Development function;Health;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Infant;Inflammation;Inflammatory;Injury;innovation;Interferons;Interleukin-6;Intervention;intestinal epithelium;intestinal injury;Intestines;intraamniotic infection;Invaded;Investigation;Knockout Mice;Knowledge;Medical;Mission;Modeling;Morbidity - disease rate;Mus;Necrotizing Enterocolitis;neonatal morbidity;Neonatal Mortality;Normal tissue morphology;novel;offspring;Organoids;Outcome;Paneth Cells;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Placenta;postnatal;Predisposition;Pregnancy;premature;Premature Birth;Premature Infant;Premature Mortality;prenatal exposure;prevent;Prevention strategy;Process;Production;Public Health;Publishing;Quality of life;recruit;Research;restoration;Risk;Role;Secondary to;Secretory Cell;Serum;Signal Pathway;Signal Transduction;Site;Source;STAT1 protein;STAT3 gene;Sterility;targeted treatment;Techniques;Testing;tissue injury;Tissues;transcription factor;United States National Institutes of Health

PROJECT_TITLE: Effect of fetal exposure to maternal inflammation on offspring Paneth cell development and homeostasis

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

ORG_CITY: Newark

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our study will identify a novel regulatory system that responses the altered nutrients to provide the better function in the heart. In this project, we will focus on lysine acetyltransferase 6A and its posttranslational modification by ketone body in order to identify new therapeutic strategies for the treatment of patients with heart failure.

PI_NAMEs: NAKAMURA, MICHINARI  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Anabolism;Attenuated;Binding;Biological Assay;Biological Process;Calories;Carbohydrates;Cardiac;Cardiac Myocytes;cardioprotection;Cell Nucleus;Clinical;deprivation;Diet;Dietary Component;Epigenetic Process;experimental study;Fasting;Fatty Acids;Future;Gene Delivery;Genomics;Glucose;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Histones;Homeostasis;Human;Hydroxybutyrates;Hypertrophy;improved;In Vitro;in vivo;Induced Cardiomyocytes;Intake;Intervention;Ketone Bodies;Knock-in Mouse;Life;Ligation;Lysine;Mammals;Mediating;Molecular;Molecular Conformation;Morphology;mTOR inhibition;Mus;mutant;Myocardial;novel;novel therapeutic intervention;Nutrient;Oral Ingestion;oxidation;Oxygen Consumption;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacologic Actions;Phenylephrine;Phosphorylation;Post-Translational Protein Processing;pressure;Primary Prevention;Production;Protein Biosynthesis;protein protein interaction;Proteomics;Regulation;Resistance;response;Role;Secondary Prevention;Signal Transduction;Source;System;Testing;Therapeutic;therapeutic target;treatment strategy;Up-Regulation

PROJECT_TITLE: Lysine Acetyltransferase 6A in Health and Cardiac Diseases

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Tetherin is a cellular factor that inhibits the detachment of virus particles from infected cells, which in turn increases the sensitivity of virus-infected cells to elimination by antibodies. The proposed studies will provide fundamental insights into the synergy between tetherin and antibodies important to the development of more effective antibody-based therapies and vaccines to combat HIV-1.

PI_NAMEs: EVANS, DAVID T (contact)

PROGRAM_OFFICER_NAME: D'SOUZA, PATRICIA D

PROJECT_TERMS: adaptive immunity;Address;Affect;AIDS prevention;Alanine;Amino Acid Sequence;Amino Acids;Animal Model;Animals;antagonist;Anti-Retroviral Agents;Antibodies;Antibody Response;antibody test;Antibody Therapy;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Binding;CD4 Positive T Lymphocytes;Cell Line;Cell surface;Cells;combat;Development;Doxycycline;Drug Design;Engineering;Epitopes;experimental study;Fc domain;HIV;HIV-1;HIV-2;Human;Immunologics;improved;in vivo;inducible gene expression;Infection;insight;Integral Membrane Protein;Interferons;Intravenous infusion procedures;Link;Macaca;Macaca mulatta;Macrophage;Mediating;mutant;Mutation;Natural Immunity;nef Genes;nef Protein;neutrophil;nonhuman primate;novel;Pathogenesis;Phagocytes;Phagocytosis;Positioning Attribute;Predisposition;prevent;Proteins;receptor;receptor binding;Resistance;Serine;SIV;Specificity;Surface;synergism;Testing;Therapeutic;Up-Regulation;uptake;Vaccines;Viral;Viral Genome;Viral Load result;Viral Pathogenesis;Viral Physiology;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Tethering lentiviral restriction to Fc-mediated antibody responses

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Physical Activity

ORG_CITY: LEXINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Exercise-based programs for hip osteoarthritis (OA) lack scientific evidence and are ineffective in conservatively treating hip OA. Current experimental protocols are unable to precisely assess the underlying pathomechanism of hip extensor dysfunction that is associated with abnormal hip joint mechanics, hip pain and cartilage breakdown during exercise in hip OA. This study will lead to the development of a novel, multi-modal experimental platform, consisting of magnetic resonance imaging, muscle-function assessment, musculoskeletal simulations and biochemical biomarkers, which will be used to assess the pathomechanism and corresponding effects of hip extensor dysfunction during aerobic exercise in patients with symptomatic hip OA.

PI_NAMEs: SAMAAN, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Advisory Committees;Aerobic Exercise;Age;age related;Aging;aging population;aging related;Area;Biochemical;Biological Markers;Biomechanics;Biometry;career;Cartilage;Cartilage Matrix;Chronic;chronic pain patient;Clinical;comparison control;Data;Degenerative polyarthritis;Development;Disease;Disease Progression;Exercise;exercise intervention;exercise program;Exhibits;Extensor;Fibrosis;Functional disorder;gait rehabilitation;Goals;Health;Hip Joint;Hip Osteoarthritis;Hip Pain;Hip region structure;Image;improved;innovation;insight;Intervention;joint loading;Knee Osteoarthritis;Knowledge;Literature;Magnetic Resonance Imaging;mammalian COMP;Measures;Mechanical Stress;Mechanics;Mentored Research Scientist Development Award;multidisciplinary;multimodality;Muscle;Muscle function;muscle physiology;Musculoskeletal;novel;novel imaging technique;older adult;Pain;Patient Self-Report;Patients;Physical therapy;Population;preservation;Principal Investigator;programs;prospective;Protocols documentation;Recommendation;Research;Research Personnel;Resources;Serum;simulation;skills;Stress Tests;symptom treatment;Techniques;Therapeutic;Torque;Total Hip Replacement;Training;United States;Work

PROJECT_TITLE: Quantifying the Mechanism and Impact of Hip Extensor Muscle Dysfunction During Aerobic Exercise in Hip Osteoarthritis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Microbiome;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE One of the reasons that explains the high mortality of pancreatic cancer and the lack of responses to most therapies is the fact that the immune system is inactive around this tumor. In this grant we aim to characterize how gut bacteria can trigger immune responses that maintain an immunosuppressive environment which favors tumor growth and resistance to therapies. We plan to study the mechanisms implicated in these events, which include epithelial regulation of immune checkpoint molecules and recruitment of neutrophils, and to target IL-17 to turn pancreatic cancer into a tumor sensitive to immunotherapy.

PI_NAMEs: MCALLISTER, FLORENCIA  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Antibiotics;Apoptosis;Blocking Antibodies;Cancer Etiology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;chronic pancreatitis;Circulation;Clinic;Colon Carcinoma;Complex;CRISPR/Cas technology;cytokine;Data;design;Development;Disease;Distant;Environment;Epithelial Cells;Epithelium;Event;FDA approved;fecal transplantation;Generations;Genetic;Genetically Engineered Mouse;Goals;Grant;gut bacteria;gut microbes;Host Defense;Human;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;in vivo;Incidence;Inflammatory;inhibitor;innovation;Interleukin Receptor;Interleukins;Intervention;Knowledge;Laboratory Finding;Learning;Lesion;Link;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Methods;microbial;Modality;Modeling;Monoclonal Antibodies;mortality;Mus;Myeloid Cells;neutrophil;Neutrophil Infiltration;novel;Oncogenic;Outcome;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic tumorigenesis;pathogen;Patients;pharmacologic;Play;Preclinical Testing;premalignant;prevent;Preventive;Process;receptor;recruit;Regulation;Reporting;Resistance;response;Risk Factors;Role;Serum;Signal Transduction;Source;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy resistant;tool;transcriptome sequencing;Translating;Transplantation;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;tumorigenesis;tumorigenic;VTCN1 gene

PROJECT_TITLE: Dissecting the source and mechanisms of IL-17-mediated modulation of pancreatic tumorigenesis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Preserving the integrity of white matter tracts (WMTs) during brain tumor surgery is necessary to maintain function and achieve the best clinical outcomes, but the absence of a clear boundary between WMTs and tumor tissue poses a significant challenge for the neurosurgeon in preserving WMTs. State-of-the-art technologies to image WMTs such as magnetic resonance imaging tractography are limited in helping surgeons preserve the integrity of WMTs, but fluorescence guided surgery (FGS), a surgical tool used to see brain tumors in different colors, provides immediate, direct visualization of tumor tissue during surgery, and has the potential to address the limitations seen with tractography. In the proposed studies, we will develop a FGS strategy by discovering a WMT-specific fluorescent probe to visualize WMTs during surgery, with the long-term goal of dramatically improving surgical outcomes by creating the first in vivo intraoperative WMT imaging technology.

PI_NAMEs: VALDES QUEVEDO, PABLO ANDRES (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Algorithms;Blood - brain barrier anatomy;Brain;Brain Edema;Brain imaging;Brain Neoplasms;brain tissue;Characteristics;Clinical;clinical translation;Color;comparative;contrast imaging;Contrast Media;Data;Development;Diagnostic;Excision;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fluorescent Probes;fluorophore;functional improvement;functional outcomes;Future;Glioma;Goals;histological stains;Histology;Histopathology;Image;image guided;imaging study;Imaging technology;Immunohistochemistry;improved;in vivo;in vivo fluorescence;Injury;Intervention;lead candidate;Libraries;Light;Location;Magnetic Resonance Imaging;Methodology;Modeling;Nerve;Neurosurgeon;novel;Operative Surgical Procedures;Outcome;Patients;Pattern;Performance;Persons;pharmacokinetics and pharmacodynamics;Pre-Clinical Model;preclinical study;preservation;Primary Brain Neoplasms;Quality of life;reconstruction;Reporting;Resolution;Rodent;Rodent Model;Series;Signal Transduction;small molecule;Specificity;stroke model;Surgeon;surgery outcome;Technology;Time;tool;tractography;tumor;Tumor Tissue;United States;Validation;Visualization;white matter

PROJECT_TITLE: White matter tract-specific near-infrared fluorescence probes for in vivo fluorescence guided white matter tractography


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Methamphetamine;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Telehealth

ORG_CITY: ELKRIDGE

ORG_NAME: EVON MEDICS, LLC

ORG_STATE: MD

PHR: NARRATIVE The proposed study will develop a sustainable, scalable, and patient-centered mobile health combinatorial product, Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR), comprised of (1) a patient-facing culturally-adapted digital-chemosensory platform for treatment of substance use disorders, sensors for acquisition of objective physiological measures of substance intoxication and withdrawal, and an application for running and interpreting these sensory acquisition programs; and (2) a provider-facing web portal, for substance use disorder treatment in socially-disadvantaged minority populations. The proposal will optimize a Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR) platform for socially disadvantaged minority populations and will evaluate the effectiveness for remote treatment of opioid use disorder, cocaine use disorder and alcohol use disorder in medically underserved populations. Accomplishment of the Aims will lead to a commercially ready product that seamlessly links patients and providers, provides effective novel treatment for stimulant use disorder, and improves remote management of SUD in digitally challenged populations.

PI_NAMEs: NWAOKOBIA, CHARLES CHIEDU (contact);NWULIA, EVARISTUS A;SETH, SUMEET

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Abstinence;active control;Address;Adoption;Adult;African American;African American population;Agonist;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Animal Model;artificial intelligence algorithm;Behavior;Beta-caryophyllene;Cellular Phone;Clinic;Clinical;cloud based;Cocaine;cocaine use;Cocaine use disorder;combinatorial;Communities;community clinic;comorbidity;computerized;Costs and Benefits;COVID-19 pandemic;craving;Custom;Data;Defect;design;Development;Devices;digital;digital solutions;digital treatment;Disadvantaged minority;Disease;Disparity population;Dopamine;dosage;Dose;Drug Controls;Drug usage;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;efficacy study;Emergency Situation;Epidemic;Evaluation;Exclusion;Failure;Feedback;Food;Funding;Future;Health;health care service;Health Insurance Portability and Accountability Act;Health Status;Heart Rate;Hispanic Americans;illiteracy;illiterate;improved;Inequity;Infrastructure;innovation;Instruction;instrument;Intake;Internet;Intervention;Intoxication;Language;Link;Machine Learning;marginalization;Maryland;Measures;Mediating;medically underserved population;medication-assisted treatment;men who have sex with men;Methamphetamine;Methamphetamine use disorder;mHealth;Midbrain structure;Minority;Minority Groups;mobile computing;Modeling;Monitor;neighborhood disadvantage;neuroregulation;non-drug;novel;Olfactory Cortex;operation;Opioid;opioid agonist therapy;opioid use disorder;opioid user;opioid withdrawal;Outcome;Overdose;patient oriented;patient population;patient portal;Patient Transfer;Patients;Pharmaceutical Preparations;Phase;phase III trial;Physicians;Physiological;Pilot Projects;Population;portability;product development;programs;Provider;psychologic;Psychophysics;Pulse Rates;randomized trial;Records;Relapse;remote delivery;Remote management;remote therapy;Research;Rewards;Running;Secure;sensor;Sensory;Services;sexual minority group;Signs and Symptoms;Site;Skin;Small Business Innovation Research Grant;social disparities;Social Distance;Social isolation;Social status;Stimulant;stimulant use;stimulant use disorder;substance use;Substance Use Disorder;substance use treatment;Testing;Text;Therapeutic;therapeutic opioid;therapeutically effective;Training;treatment as usual;Treatment outcome;underserved community;Universities;Virus Diseases;Visual;Voice;Washington;web portal;wireless fidelity;Withdrawal

PROJECT_TITLE: The Development and Evaluation of Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Although 24 million Americans suffer from one of the 80 different types of autoimmune disease, the underlying causes are not well understood, and accurate diagnosis can be difficult. Leukocytes are essential immune components that should protect the body against foreign invaders, however dysregulation can instead lead to autoimmune diseases. We aim to uncover the regulation mechanisms and characterize the functions of transmembrane receptors that are highly expressed on the leukocyte surface to provide a blueprint for the rational design of highly-specific therapeutics for autoimmune diseases.

PI_NAMEs: CAMPBELL, MELODY G (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: accurate diagnosis;Adhesions;American;Antibodies;Autoimmune;Autoimmune Diseases;Binding Proteins;Biochemical;Biophysics;Cardiac;Cell Communication;Cell membrane;cell motility;Cell surface;Cells;Communicable Diseases;Complex;copolymer;Cryoelectron Microscopy;Cytoplasm;design;drug development;Environment;experimental study;Extravasation;Goals;Immune;insight;Integral Membrane Protein;Integrin Binding;Integrins;Lead;Leukocytes;Ligand Binding;Ligands;Link;maleic acid;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;method development;Methods;migration;mimetics;Molecular;Molecular Conformation;Mutate;nanodisk;next generation;Phagocytosis;Polymers;Pulmonary Pathology;rational design;receptor;Regulation;Resolution;Role;side effect;Signal Transduction;Specificity;Styrenes;Surface;System;Talin;Therapeutic;therapeutic target;Work

PROJECT_TITLE: The Molecular Basis for Integrin-Mediated Bidirectional Signaling

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Release of neuromodulators, such as serotonin (5-HT), have profound effects on neural circuits and behavior and change following chronic stress. Here, we propose to dissect the selective cellular and circuit effects of a neuromodulator, 5-HT, on specific neuronal subtypes within the lateral habenula (LHb) in vitro and in vivo in mice. Furthermore, following chronic stress we will examine how a common treatment for depression (administration of selective serotonin reuptake inhibitors (SSRIs)) modifies the temporal dynamics of 5-HT and effects neuronal activity in the LHb in vivo to understand how activity of specific LHb neuron-types change and effect behavior.

PI_NAMEs: WALLACE, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Action Potentials;Acute;Affect;Anhedonia;anti-depressive agents;Arousal;Axon;Behavior;Behavioral;behavioral phenotyping;Brain;Brain region;Calcium;cell type;Cells;Chronic stress;cognitive process;Color;common treatment;Data;differential expression;Disease;Dopamine;Electrophysiology (science);Emotional;Exhibits;Fire - disasters;fluorophore;Foundations;G-Protein-Coupled Receptors;Genes;Habenula;Head;hindbrain;Human;Hyperactivity;improved;In Vitro;in vivo;in vivo evaluation;Individual;Ion Channel;Lateral;Learning;Link;Longitudinal Studies;Major Depressive Disorder;Measures;Mediator;memory process;Mental Depression;Mental disorders;Methods;Midbrain structure;motivated behavior;motor control;Mus;Nervous System Disorder;neural circuit;Neuromodulator;neuronal circuitry;Neurons;Norepinephrine;Optics;Outcome;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Prosencephalon;Psychiatric therapeutic procedure;Psychological reinforcement;receptor;Reporting;Rodent Model;Selective Serotonin Reuptake Inhibitor;sensor;Serotonin;serotonin receptor;spatiotemporal;Stress;Structure;Synapses;Synaptic Transmission;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;transcriptome;transcriptomics;Work

PROJECT_TITLE: Serotonergic modulation of the circuits and cell-types of the lateral habenula

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Parkinson’s disease and other movement disorders are devastating disorders that disrupt quality of life for individuals and their families. This predoctoral program involving Interdisciplinary Training in Movement Disorders and Neurorestoration (MDNR) is designed to help build a group of rigorously trained, scientifically competent and innovative young scientists who can make a difference in the lives of individuals with movement disorders by advancing research in etiology and treatment of movement disorders.

PI_NAMEs: ARMSTRONG, MELISSA JO;VAILLANCOURT, DAVID E (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative MRI, and particularly diffusion MRI, is the best imaging method to distinguish healthy prostate from potentially lethal cancer, but because it uses hardware that is built into the MRI scanner, these images have lower signal overall, and not all cancers are visible. We propose a new kind of hardware, a wand placed between the legs during scanning, that will dramatically increase both the signal and contrast in diffusion MRI, improving image quality and making cancers easier to find and monitor. This hardware will improve the imaging of prostate cancers, so that doctors reliably know what they're dealing with, which will reduce both underdiagnosis and overtreatment of this disease.

PI_NAMEs: GALIANA, GIGI  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3D Print;Adopted;Anatomy;Biopsy;Brain;Breast;Clinical;clinical practice;Clinical Trials;clinically significant;connectome;Consensus;cost;Custom;Data;design;Devices;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Epithelium;Erectile dysfunction;Future;Geometry;Gleason Grade for Prostate Cancer;high resolution imaging;Histologic;Histopathology;Human;Image;Image Analysis;imaging modality;improved;in vivo;Incontinence;innovation;interest;invention;Leg;Lesion;lifetime risk;Liver;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;men;Methods;Monitor;Noise;non-invasive imaging;Organ;Outcome;overtreatment;Pathology;Patient imaging;patient population;Patients;Performance;Physiologic pulse;Population;portability;Positioning Attribute;premature;Prostate;prostate cancer risk;prostate lesions;Prostatectomy;prototype;Radical Prostatectomy;radiologist;Reader;Reproducibility;Research;Safety;Scanning;Sensitivity and Specificity;Signal Transduction;simulation;Slice;Specific qualifier value;Technology;Time;Tissues;Work

PROJECT_TITLE: Inside-Out Nonlinear Gradients to Improve Diffusion MRI


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Genomics research is predominantly conducted in homogenous populations of European-descent, limiting the generalizability of genomic findings and hindering the identification of biological pathways underlying disease and the development of equitable tools for the translation of findings to human health for minority populations. Using existing data, this proposal will comprehensively model the interaction of both global and local ancestry with genetic and non-genetic risk factors in admixed populations, who have increased genetic heterogeneity both within and between groups. By drawing upon genetic epidemiology, statistical genetics, and population genetics, the resulting catalog of human ancestry’s role on the genetic underpinnings of disease will better inform methodological development and the application of genomic medicine to bridge existing health inequities.

PI_NAMEs: WOJCIK, GENEVIEVE LIANNE (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;Admixture;Awareness;Biological;Biomedical Research;Catalogs;clinical translation;cohort;Communities;Data;Development;Disease;Environment;Epidemiology;Equity;European;Evaluation;Future;gene environment interaction;Gene Frequency;Genes;Genetic;genetic epidemiology;Genetic Heterogeneity;genetic variant;Genome;genome wide association study;genome-wide;Genomic medicine;Genomics;Haplotypes;Health;health inequalities;Human;Individual;Investigation;Linkage Disequilibrium;method development;Methodology;Minority Groups;minority health;Modeling;next generation;non-genetic;Pathway interactions;Pattern;pleiotropism;polygenic risk score;Population;Population Genetics;portability;Prevalence;programs;Publishing;Research;research and development;Research Design;Risk;Risk Assessment;Risk Factors;Role;statistics;study characteristics;Sum;tool;trait;Translations;Variant;variant of interest

PROJECT_TITLE: The influence of genetic ancestry and population-specific epidemiology on the transferability of genomic findings to diverse and admixed populations


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Public Health Relevance Statement (Project Narrative)  While long-acting antiretroviral therapy (ART) is effective, its pharmacology in the real world, where patient management problems have emerged, is unclear. This application will address this gap and develop new real-time and point-of-care measurements of drug concentrations in PWH receiving long-acting ART.

PI_NAMEs: ANDERSON, PETER L. (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Address;AIDS prevention;Aliquot;antiretroviral therapy;Appointment;Archives;Biological Assay;Blood;Caring;Categories;Classification;Clinic;clinical care;Collection;Colorado;Communicable Diseases;Controlled Clinical Trials;Data;Development;Devices;Dose;drug classification;Drug Kinetics;empowerment;Enrollment;experience;FDA approved;Formulation;Frequencies;Future;Goals;Grant;Group Practice;healthcare burden;HIV;HIV Infections;HIV therapy;Home;Influentials;Infrastructure;Injectable;Injections;innovation;Knowledge;Laboratories;Learning;Longitudinal cohort;mass spectrometer;Mass Spectrum Analysis;Measurement;Mind;Modality;models and simulation;Monitor;novel;Participant;Patient Care;Patients;personalized strategies;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;point of care;point of care testing;pre-exposure prophylaxis;Prevention;Provider;public health relevance;resistance mutation;Risk Factors;sample collection;Sampling;Stream;success;Technology;Testing;Time;Translating;Universities;Validation;Vision;Visit

PROJECT_TITLE: A platform for monitoring the efficacy and optimal dosing of long-acting ART

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Dry mouth is the frequent side effect of medications, which impairing the cholinergic stimulation of saliva secretion can lead to dry mouth, dental caries, soft tissue damage, and problems with speaking and swallowing. While the saliva secretion is very sensitive to these anticholinergic medications showing a significantly increased usage among adults, information on the oral health side effects is minimal. We propose to assess the salivary secretion and oral health outcomes in dental patients taking anticholinergic medications and explore the role of genetic variations of drug-metabolizing enzymes in the development of dry mouth.

PI_NAMEs: ARANY, SZILVIA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Affinity;Age;age effect;aging population;Alleles;antagonist;Anti-Cholinergics;anti-depressive agents;Appointment;Australia;Biological Assay;Blood;Chemosensitization;cholinergic;Cholinergic Agents;Cholinergic Receptors;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;curative treatments;CYP2C19 gene;CYP2D6 gene;Cytochrome P450;Cytochromes;Data;Deglutition;Delirium;Dementia;Dental;Dental caries;design;Development;DNA;DNA analysis;double-blind placebo controlled trial;drug metabolism;Drug Prescriptions;Dryness;Dyskinetic syndrome;early screening;Elderly;Enzymes;Equipment and supply inventories;Europe;Feeling;Frequencies;Future;Genetic;Genetic Markers;Genetic Polymorphism;genetic variant;Genetic Variation;genotyped patients;Goals;Health;high risk;human old age (65+);Impaired cognition;Impairment;Individual Differences;Infection;Intake;inter-individual variation;Investigation;Liver;Mastication;Measurement;Measures;Memory impairment;Metabolic;middle age;Minor salivary gland structure;Monitor;Mucous Membrane;Muscarinic Acetylcholine Receptor;Muscarinics;Neurologic;neuroregulation;neurotransmission;North America;Oral;Oral cavity;Oral health;Oral Health Impact Profile;Organ;Outcome;Parasympathetic Nervous System;Patients;Peripheral;personalized medicine;Pharmaceutical Preparations;pharmacogenetic variants;Pharmacogenetics;Phenotype;point of care;point of care testing;Polypharmacy;Population;Predisposition;Prevalence;Prevention;Property;Prophylactic treatment;prospective;Prospective, cohort study;Psychoses;Quality of life;Questionnaires;Randomized;receptor;recruit;Reporting;Research;Risk;risk prediction;Role;Saliva;saliva secretion;Salivary;Salivary Glands;screening;Serum;Severities;side effect;Signal Transduction;soft tissue;Spasmolytics;Surveys;Symptoms;Testing;Tooth Loss;Toxic effect;treatment strategy;Upper Respiratory Infections;Upper respiratory tract;urinary;Visit;Xerostomia

PROJECT_TITLE: Impact of Anticholinergic Medication on Salivary Function; Exploring Potential Genetic Markers for Dry Mouth

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Services;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because liver cirrhosis affects a large segment of the elderly population with high mortality and high risk for decompensation requiring resource-intensive care, yet little knowledge exists about disease progression and risk prediction. We use a large population based dataset, Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN), which captures the electronic health records (EHR) from nine health systems from 2011-present (incl. academic center, county, VA and private), catching most of the diverse patient population in a large metropolitan area, namely ~160,000 patients with liver cirrhosis. With a strong analytical and clinical team we will use traditional and machine learning techniques to study disease progression and risk prediction in older patients with cirrhosis.

PI_NAMEs: LADNER, DANIELA P (contact);MEHROTRA, SANJAY

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: adjudication;Affect;Area;Ascites;Attention;black patient;Black race;Caring;Cause of Death;Cessation of life;Chicago;Cirrhosis;Clinical;cost;County;Data;data repository;Data Set;Debility;deep learning;Development;Diagnosis;disability;disease model;Disease Progression;disorder risk;Elderly;Electronic Health Record;end stage liver disease;Epidemiology;epidemiology study;Event;Gastrointestinal Hemorrhage;Graph;Health system;Hepatic Encephalopathy;high risk;Hospitalization;improved outcome;Infection;Inpatients;Insurance;Intensive Care;Intervention;Knowledge;Life Experience;Liver;Liver Cirrhosis;Machine Learning;Medical;metropolitan;Modeling;mortality;mortality risk;novel;older adult;older patient;Older Population;organ allocation;Outcomes Research;patient population;Patient Representative;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Persons;Population;population based;predictive modeling;Primary carcinoma of the liver cells;Privatization;Probability;Public Health;Race;Research;Resources;Risk;Risk Estimate;Risk Marker;risk prediction;Risk Reduction;Sampling;Sampling Biases;Socioeconomic Factors;Subgroup;Techniques;Time;Transplantation;United Network for Organ Sharing;United States;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;Work;young adult

PROJECT_TITLE: LIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: Narrative Using data obtained with electrophysiological recordings spanning multiple spatial scales in humans and non- human primates, coupled with advanced data analyses, we are developing a detailed computational model of the brain’s driving and modulatory circuits, and their hallmark neuronal oscillatory dynamics. These “dynamic circuit motifs” support distinct functions, that integrate auditory processing with other critical functions including selective attention, motor operations, and memory recall. We will use the model and experimental data to better understand the brain and the characteristic neuronal deficits underlying a variety of brain diseases. We will utilize model-based neuromodulation in order to causally verify the function of identified circuits and neuronal activity patterns. These precisely targeted neuromodulation methods could be used in the future to restore intricate balances of neuronal oscillatory dynamics that are disrupted in hearing disorders, as well as in neuropsychiatric conditions.

PI_NAMEs: BICKEL, STEPHAN ;NEYMOTIN, SAMUEL A;O'CONNELL, MONICA NOELLE (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Action Potentials;Anatomy;Animal Model;Area;Attention;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;Automobile Driving;Behavior;Behavioral;Brain;Brain Diseases;Cells;Characteristics;Clinical;Communities;Complex;Computer Models;Coupled;Cues;Data;Data Analyses;data analysis pipeline;Data Collection;Decision Making;design;Electric Stimulation;Electrical Stimulation of the Brain;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Environment;Epilepsy;experimental study;Eye Movements;Fingerprint;Functional disorder;Future;goal oriented behavior;Goals;Hearing;Hearing problem;Human;Implant;improved;Link;Location;Maps;Measures;memory recall;Methods;Modeling;Motivation;Motor;Movement;multimodality;multisensory;neural;neuronal circuitry;Neurons;neurophysiology;neuropsychiatry;neuroregulation;Neurosciences;nonhuman primate;operation;Operative Surgical Procedures;Patients;Pattern;Performance;Periodicity;Physiological Processes;Play;predictive modeling;Primates;Probability;Process;Property;response;Rodent;Role;Saccades;Sampling;selective attention;Sensory;Signal Transduction;Site;Study models;success;Support System;System;Testing;Thalamic structure;Translating;Translations;transmission process;ultra high resolution;Visual;Visual attention;visual stimulus;Waxes

PROJECT_TITLE: Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Narrative While the majority of genes in a genome are dispensable, a relatively small number of genes are essential under any circumstance and are generally seen as rigid genetic components, consequently making them excellent antimicrobial targets. Preliminary work has shown that many essential genes can lose their essentiality depending on the genetic background, making them evolvable. Here we determine what makes an essential gene evolvable, we test whether evolvable essentiality is predictable, what the phenotypic and mechanistic consequences are (especially for cell wall synthesis), whether there are fitness costs and/or adaptability changes and, importantly, we apply our newly found knowledge to design a proof-of-principle gene-targeting drug screen.

PI_NAMEs: ROSCH, JASON W. (contact);ROSCONI, FEDERICO ANTONIO

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Affect;Anabolism;antimicrobial;Bacterial Genome;Behavior;Biological;Buffers;Categories;Cell division;Cell Wall;Cellular Morphology;Clinical;Comparative Genomic Analysis;comparative genomics;cost;CRISPR interference;Data;design;Drug Screening;Engineering;Environment;Essential Genes;Evolution;fitness;fluidity;Foundations;gene function;Gene Targeting;Gene Transfer;Genes;Genetic;Genetic Variation;Genome;genome sequencing;genome-wide;genomic data;genomic tools;Genomics;Knock-out;Knowledge;large datasets;Liquid substance;Machine Learning;machine learning model;Maps;Microscopy;Mutation;network architecture;novel;Organism;pan-genome;pathogenic bacteria;Pathway Analysis;Pathway interactions;Phenotype;Process;Rest;Role;Sampling;Streptococcus pneumoniae;Stress;Testing;tool;transposon sequencing;Virulence;whole genome;Work

PROJECT_TITLE: Evolvable essentiality in the pan-genome of Streptococcus pneumoniae and its mechanistic and evolutionary consequences

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurodegenerative;Neurosciences;Substance Misuse;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Women are more vulnerable than men to many of the consequences of alcohol use including neurodegeneration and impaired neurocognitive function which lead to poorer treatment outcomes. The proposed differences multimodal training and research will identify sex in the molecular and neural mechanisms of neurodegeneration in alcohol use disorder using imaging — positron emission tomography and diffusion tensor magnetic resonance imaging. provide the candidate with the expertise necessary to This project will identify sex differences in alcohol-induced markers of neurodegeneration (i.e., microglia and white matter) that lead to neurocognitive impairments to identify promising translational treatment targets.

PI_NAMEs: ZAKINIAEIZ, YASMIN  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Abstinence;addiction;Address;Age;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol use disorder;Alcohols;Archives;Area;Axon;axon injury;Binding;Biometry;Brain;brain cell;Brain imaging;career;Cerebellum;cerebral atrophy;Clinical;collaborative environment;connectome;Corpus Callosum;Data;Data Analyses;Data Collection;Data Set;Demyelinations;design;Diffusion;Disease;Educational workshop;executive function;experience;Female;Fiber;Functional disorder;Goals;Growth;Hippocampus;Human;Image;imaging modality;imaging study;Impairment;improved;in vivo;Individual;innovation;Magnetic Resonance Imaging;male;Measures;medical schools;Memory impairment;men;Mentored Research Scientist Development Award;Mentors;Microglia;Modeling;Molecular;MRI Scans;Multimodal Imaging;multimodal neuroimaging;multimodality;Nerve Degeneration;Neurobiology;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuroimaging;neuromechanism;Neurosciences;novel;Outcomes Research;Pattern;Play;Positron-Emission Tomography;Pre-Clinical Model;Prefrontal Cortex;Productivity;programs;Proteins;Publications;radiotracer;Recovery;Research;Research Personnel;restoration;Role;Sampling;Scientist;sex;sex as a biological variable;Sex Differences;Short-Term Memory;skills;Smoking;Structure;Supervision;symposium;theories;Time;Training;Training Programs;Treatment outcome;United States;white matter;Woman

PROJECT_TITLE: Sex Differences in Alcohol Use Disorder Neurodegeneration using Multimodal PET and DTI Neuroimaging

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Relevance Statement: Acute myeloid leukemia (AML) is the second most common childhood leukemia and has a dismal prognosis. For over 40 years AML chemotherapy has changed little with the continued reliance on ara-C, daunorubicin and etoposide as frontline agents. The proposed research seeks to prepare a sound scientific rationale to incorporate prognostic gene expression scores into the risk stratification of AML patients and revealing additional layers of the molecular basis of AML prognosis to guide the development of more effective treatments for AML.

PI_NAMEs: LAMBA, JATINDER K. (contact);POUNDS, STANLEY BARRETT

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acceleration;Achievement;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Adult Acute Myeloblastic Leukemia;Ara-C;Azacitidine;Biological;Book Chapters;cancer genomics;Cell Line;chemotherapy;Childhood;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Clinical;clinical practice;Clinical Trials;clinically significant;cohort;Collaborations;Combination Drug Therapy;CRISPR/Cas technology;Custom;Data;Daunorubicin;Decitabine;demethylation;Development;Diagnosis;Disease;Disease Resistance;DNMT3B gene;effective therapy;Enrollment;Environment;epigenomics;Etoposide;Evaluation;Exposure to;Failure;Florida;Foundations;Funding;Gene Expression;Genes;Genetic Transcription;genome wide association study;genome wide methylation;Genomics;In Vitro;innovation;International;Knock-out;Legal patent;leukemia treatment;Leukemic Cell;leukemic stem cell;Methods;Methylation;Molecular;molecular domain;novel;older patient;Outcome;Patients;Pediatric Oncology;Pediatric Oncology Group;pediatric patients;Pharmaceutical Preparations;Pharmacogenetics;Pharmacology;Procedures;Productivity;Prognosis;prognostic;Prognostic Factor;prospective;Publications;Qualifying;Randomized;Rare Diseases;Recurrent disease;Research;Research Personnel;Resistance;risk stratification;Saint Jude Children's Research Hospital;Sample Size;Sampling;Site;sound;Statistical Methods;success;symposium;transcriptomics;Translating;Translational Research;Translations;Universities;Validation;Variant;Vertebral column

PROJECT_TITLE: Genomics of AML Prognosis

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative  Discovering mechanisms to enhance adult brain function is of utmost importance when devising therapeutics to recover and refine normal brain function later in life. We found that temporarily depriving vision leads to recovery of plasticity in the adult auditory cortex, which can benefit auditory function. In this proposal, we aim to determine the mechanisms that allow recovery of adult brain plasticity, and whether temporary visual deprivation improves auditory performance in adults.

PI_NAMEs: KANOLD, PATRICK O;LEE, HEY-KYOUNG  (contact)

PROJECT_TERMS: Adult;Affect;Area;Auditory;Auditory area;auditory processing;auditory thalamus;Automobile Driving;Behavior;Behavioral;behavioral outcome;Blindness;Brain;Cell Nucleus;Cells;Chemosensitization;Cochlear Implants;critical period;Data;Detection;Development;discrimination task;Disinhibition;Environment;Excitatory Synapse;experience;Feedback;Hearing;Image;improved;in vivo;information processing;Injury;insight;Lateral;Life;Mediating;Modality;Mus;Nerve Degeneration;Neurons;Neurophysiology - biologic function;novel;Operative Surgical Procedures;Organ;Patients;Performance;Peripheral;Population;postnatal development;Prognosis;Publishing;receptive field;Recovery;Recovery of Function;Regulation;Reporting;Research;response;Role;Sensory;Signal Transduction;sound;Source;speech recognition;Stimulus;Stroke;success;Synapses;Testing;Thalamic structure;Therapeutic;therapy development;Time;Tinnitus;two-photon;Vision;Visual;visual deprivation;Visually Impaired Persons;vocalization;Work

PROJECT_TITLE: Cross-modal enhancement of auditory plasticity and performance in adults


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: The major proteins found in the human eye lens are called crystallins and they become extensively modified during aging and cataract formation. These modifications include oxidation and a spontaneous chemical change, called deamidation. Our long-term goal is to determine how these modifications cause structural changes in the crystallins that lead to the large light scattering aggregates found in cataracts in order to intervene in the aggregation process and slow cataract formation.

PI_NAMEs: LAMPI, KIRSTEN JEANNE (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Age;Age of Onset;age related;aged;Aging;amyloid fibril formation;Antioxidants;biophysical properties;Cataract;Cell Nucleus;Chemicals;crosslink;Crystalline Lens;Crystallins;Data;deamidation;Deuterium;Development;dimer;Dimerization;Disease;Distant;disulfide bond;Disulfides;Environment;Etiology;experimental study;gamma-Crystallins;Glutamine;Glutathione;Goals;Grant;Human;Hydrogen;In Vitro;in vivo;insight;ion mobility;Laboratories;Lead;lens;light scattering;Link;Mass Spectrum Analysis;Mediating;Methods;model development;Modification;molecular modeling;non-Native;Nuclear;oxidation;Pathway interactions;peptide A;Pharmaceutical Preparations;Post-Translational Protein Processing;Predisposition;Process;protein aggregation;Protein Dynamics;Proteins;Reporting;Resolution;response;Structure;Testing;therapeutic development;Work

PROJECT_TITLE: Aggregation of Deamidated Crystallins as a Major Cause of Cataracts

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative: Regulation of stem cell self-renewal is critical for tissue homeostasis and disease development and the goal of this project is to understand the collaborative role of HOTTIP/β-catenin-HOXA9/PRMT1 axis in hematopoietic stem cell (HSC) regulation and early pathogenesis of AML. Our proposal will characterize the function of individual components and their crosstalk along the axis in regulating hematopoietic self-renewal. The studies will provide novel mechanistic insights and potential therapeutic targets for modulating hematopoietic self- renewal.

PI_NAMEs: ERIC, SO ;HUANG, SUMING  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;beta catenin;Binding;Biochemical;Biological;Bone marrow failure;cancer stem cell;Cell Line;Cells;cohesin;cohesion;Complement;Complex;Degenerative Disorder;design;Development;Disease;DNA Damage;DNA Repair;DNA Repair Pathway;Enhancers;Epigenetic Process;Future;gain of function;gene regulatory network;Genetic;Genetic Transcription;Genome;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic gene;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeodomain Proteins;Homeostasis;HOXA9 gene;Human;Individual;insight;Knock-in Mouse;leukemic stem cell;Link;loss of function;Malignant - descriptor;Malignant Neoplasms;malignant phenotype;Mediating;Mediator;Molecular;Molecular Analysis;Mus;Natural regeneration;novel;NURF;Oncogenic;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Play;Population;Premature aging syndrome;programs;promoter;Property;protein function;Protein-Arginine N-Methyltransferase;Proteins;Regulation;Repair Complex;repair function;Reporting;response;Role;RUNX1 gene;self-renewal;small molecule inhibitor;Stat5 protein;stem cell self renewal;stem cells;success;Techniques;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;transcription factor;Transcriptional Regulation;Translating;Untranslated RNA;Validation;WNT Signaling Pathway

PROJECT_TITLE: Role of HOTTIP/beta-catenin-HOXA9/PRMT1 axis in hematopoietic and leukemic stem cells

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Brain Disorders;Depression;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE During development, individual neurons extend highly branched neurites that innervate the surrounding territory with minimal overlap to form appropriate synaptic connections. Failure to establish proper neural networks has been linked to neurodevelopmental and neuropsychiatric disorders, including Autism Spectrum Disorder, Schizophrenia and Major Depressive Disorder. Our proposal will investigate the molecular mechanisms by which the protocadherin gene cluster contributes to neural circuit formation during development and may provide new insights into disease mechanisms, motivating the development of new therapeutic interventions.

PI_NAMEs: MANIATIS, THOMAS P (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;autism spectrum disorder;Axon;Behavior;Brain;Cell membrane;Cell surface;cell type;Cells;Data;Defect;Development;Disease;Dopamine;dopaminergic neuron;Ensure;Exons;Failure;Family;Fright;Gene Cluster;Gene Deletion;Gene Expression Regulation;Genes;Genetic Transcription;GTP-Binding Proteins;Human;Immunoglobulin Constant Region;in vivo;Individual;insight;Label;Laboratories;Link;Logic;Major Depressive Disorder;Mammals;Mediating;Mental Depression;Methods;Midbrain structure;Molecular;Mus;neural;neural circuit;neural network;Neurites;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;Neurons;neuropsychiatric disorder;neuroregulation;novel;novel therapeutic intervention;olfactory sensory neurons;Pattern;Phenotype;Physiological;prevent;Process;Protein Isoforms;Proteins;receptive field;Regulation;response;Rewards;RNA Splicing;Role;Schizophrenia;self organization;Serotonin;Shapes;Signal Pathway;Signal Transduction;Sister;Structure;Surveys;Synapses;transcriptomics;Vulnerable Populations;Work

PROJECT_TITLE: The role of the clustered protocadherins in neural circuit formation and implications for neurodevelopmental disorders


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Imaging mass spectrometry is a powerful technology that enables the visualization of biochemical processes directly in tissue specimens. Especially when this technology is used to study lipids and metabolites, many compounds with similar chemical structures are present that can obscure these analyses. Our lab proposes to develop novel instrumentation and gas-phase reactions to better differentiate and identify these compounds so as to more accurately determine their unique cellular functions in a wide variety of biomedical research settings, such as in studies of diabetes, infectious disease, cancer, and drug pharmacology.

PI_NAMEs: PRENTICE, BOONE M. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Affect;Amines;Amino Acids;Biochemical;Biochemical Pathway;Biochemical Process;Biological;Biological Process;Biomedical Research;Cell Physiology;Cells;Chemical Structure;Chemicals;Chemistry;Choline;Chromatography;Clinical;Communicable Diseases;Complex Mixtures;design;Detection;detection limit;detector;Development;Diabetes Mellitus;experimental study;Failure;Fatty Acids;flexibility;Functional disorder;functional group;Gases;Generations;Goals;Head;Image;imaging approach;imaging modality;improved;In Situ;Individual;instrument;instrumentation;interest;Ions;Isomerism;Kinetics;Label;Lecithin;lipidomics;Lipids;Malignant Neoplasms;Maps;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;metabolomics;Methodology;Methods;microscopic imaging;Modification;Molecular;molecular imaging;molecular mass;novel;Peptides;Performance;Pharmaceutical Preparations;Pharmacology;Phase;Phosphatidylethanolamine;Phosphatidylserines;pi bond;Play;Positioning Attribute;prevent;Proteomics;Reaction;Reagent;Reproducibility;Resolution;Resources;Role;Sampling;Scanning;Series;Signal Transduction;Site;small molecule;Spatial Distribution;Specificity;Specimen;Speed;Sphingomyelins;Surface;tandem mass spectrometry;Technology;Time;Tissue imaging;Tissue Sample;Tissues;tool;treatment strategy;Visualization

PROJECT_TITLE: Imaging mass spectrometry at isomeric chemical resolution using gas phase ion/ion reactions

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Age-related macular degeneration (AMD), the most common cause of blindness among the elderly, is characterized by retinal pigment epithelium (RPE) cells that are morphologically heterogeneous and with various degrees of dysfunction and degeneration. RPE cells, that are critical for photoreceptor functioning and survival, have very high energy demands and are exposed to very high stress and in fact, RPE mitochondrial dysfunction and impaired stress response have been implicated in AMD. This proposal will study how Pink1 mediated mitophagic impairment recruits Nrf2 stress response pathway genes to induce EMT and affect RPE structure and function in AMD, which can lead to novel therapies for dry AMD based on Pink1 and Nrf2 pathways.

PI_NAMEs: DATTA, SAYANTAN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Age related macular degeneration;animal facility;Animal Model;Antioxidants;Archives;Area;biological adaptation to stress;Biology;Blindness;career;Cause of Death;Cell Death;Cell Line;Cell Nucleus;Cell Survival;cell type;Cells;Cellular biology;Cellular Morphology;Cessation of life;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complement;CRISPR/Cas technology;Defect;Doctor of Philosophy;Dryness;effective therapy;Elderly;Environment;epithelial to mesenchymal transition;Epithelium;Evaluation;Excision;experimental study;Exposure to;Failure;Functional disorder;Gene Expression;Gene Modified;Gene Transfer;Genes;Heterogeneity;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vivo;induced pluripotent stem cell;innovation;Invaded;knock-down;Knock-out;Knockout Mice;Learning;Mediating;Mentors;Mentorship;Mesenchymal;migration;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Genetics;Morphology;mouse model;Mouse Strains;multidisciplinary;Mus;mutant;new therapeutic target;Nonexudative age-related macular degeneration;novel;novel therapeutics;Nuclear Translocation;Oxidative Stress;Pathway interactions;Patients;Phase;Phenotype;Photoreceptors;PIK3CG gene;PINK1 gene;Predisposition;recruit;Rejuvenation;Research;Resistance;Resources;response;Retina;Role;Sampling;Scientist;Shapes;Signal Induction;Signal Transduction;stem cell biology;stem cells;Stress;Structure;Structure of retinal pigment epithelium;targeted treatment;Techniques;Technology;Testing;tissue degeneration;Training;transcriptome;transcriptome sequencing

PROJECT_TITLE: Mitochondrial retrograde signaling in RPE heterogeneity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Currently, there is no effective treatment that can prevent or reverse the cognitive function impairment in Alzheimer's disease. This project will examine the biology of MG53, a tissue repair gene, in neuroprotection. Our findings with the dual function of MG53 in tissue repair and anti-inflammation shall provide novel means to mitigate neurodegeneration associated with the progression of Alzheimer's disease.

PI_NAMEs: MA, JIANJIE  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Abeta synthesis;Address;Adverse effects;Age Months;age related;age related neurodegeneration;age related neuroinflammation;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;amyloid formation;Animal Model;Animals;Anti-Inflammatory Agents;Biochemical;Biology;Blood - brain barrier anatomy;Blood Circulation;Brain;Brain Injuries;Cell membrane;Cerebrospinal Fluid;chemokine;Chronic;Circulation;Clinical;Clinical Course of Disease;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive function;Collaborations;controlled cortical impact;cytokine;Data;Deterioration;Disease Progression;Dose;Doxycycline;effective therapy;Experimental Designs;Family suidae;Free Radicals;gene repair;Genes;Goals;healthspan;Heart failure;Hippocampus;Human;Imaging Device;Impaired cognition;Impairment;Inflammation;Inflammatory;Injury;Innate Immune System;innovation;insight;Interleukin-1 beta;Interleukin-6;intravenous administration;Knock-in Mouse;Link;Lipopolysaccharides;live cell imaging;Maintenance;member;Memory impairment;Messenger RNA;Microglia;Moderate Exercise;mouse model;Mus;nano-string;Nerve Degeneration;neural;Neurofibrillary Tangles;neuroinflammation;Neurologic;neuron loss;Neuronal Injury;Neurons;neurophysiology;neuroprotection;neurotoxicity;novel;Ohio;old mice;Organ;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Pathway interactions;Physiology;Pilot Projects;Play;porcine model;preservation;prevent;Production;promoter;Protein Family;Proteins;Publications;Rattus;Recombinants;repaired;Research;Resistance;response;Rodent;Role;Safety;Senile Plaques;Signal Transduction;Skeletal Muscle;slow potential;Stress;Testing;Therapeutic;Therapeutic Agents;tissue repair;Tissues;Toxic effect;Transgenic Mice;Translating;Traumatic Brain Injury;TRIM Gene;Universities

PROJECT_TITLE: Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Motile cilia are microtubule-based organelles that produce a driving force for cellular locomotion and extracellular fluid flow. In humans, paralyzed or dyskinetic cilia can lead to infertility, chronic respiratory disease, and laterality abnormalities. This project aims to reveal the detailed structures of the multiple dynein motors that power ciliary motility, helping to identify key aspects of their assembly and function that could be targeted for novel therapies of cilia dysfunction.

PI_NAMEs: BROWN, ALAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;arm;ATP phosphohydrolase;Binding;Biochemical;Bos taurus;Calcium;Cattle;Cerebrospinal Fluid;Chemicals;Chlamydomonas;Chlamydomonas reinhardtii;Chronic;chronic respiratory disease;Cilia;ciliopathy;Cilium Microtubule;cilium motility;Classification;Complex;Cryoelectron Microscopy;Data;Diagnosis;Docking;driving force;Dynein ATPase;Elements;Embryonic Development;Etiology;Evolution;Extracellular Fluid;Family;Fertility;Flagella;fluid flow;Frequencies;Functional disorder;Genetic study;Handedness;Hereditary Disease;Human;Infertility;insight;Location;Locomotion;Mastigophora;Mechanics;Methods;Microtubules;model organism;Molecular;Motility;Motor;Movement;Mucous body substance;Mutagenesis;Mutation;Natural Immunity;Neonatal Respiratory Distress;new therapeutic target;Nucleotides;Oocytes;Organelles;Organism;Paralysed;particle;Pattern;Periodicals;Periodicity;Physiology;Play;Positioning Attribute;Power stroke;preservation;Radial;Rationalization;Regulation;Resolution;respiratory;Respiratory Tract Infections;response;Role;Speed;sperm cell;Structure;targeted treatment;Video Microscopy;Work

PROJECT_TITLE: Structural characterization of single, double and triple-headed axonemal dyneins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_DEPT: GENETICS

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This proposed research is relevant to the mission of the NIH because uncovering the underlying mechanisms linking energy/nutritional intake and pathology will provide novel therapeutics to both prevent and cure multiple age-onset diseases, which represent ever growing burdens to public health.

PI_NAMEs: MAIR, WILLIAM B (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 5'-AMP-activated protein kinase;Afferent Neurons;Age of Onset;age-related disease;Aging;Amino Acids;Animal Model;Biological Models;Body Size;Caenorhabditis elegans;cell type;Cells;Centenarian;Chronic;Chronic Disease;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;cost;Coupled;CREB1 gene;Data;Defect;defined contribution;Developmental Delay Disorders;Diagnosis;Diet;Diet therapy;dietary;dietary restriction;Disease Resistance;Distal;Eating;Elderly;Energy Metabolism;extend lifespan;Fasting;fitness;FRAP1 gene;Funding;gene-editing approach;Geroscience;Goals;Growth;healthspan;healthy aging;human old age (65+);hypoxia inducible factor 1;Immunity;Impairment;Intake;Life;life span;Link;Longevity;Macronutrients Nutrition;Malnutrition;Mediating;Mediator;Metabolic;Metformin;Methods;Mission;Mitochondria;mitochondrial metabolism;Molecular;Molecular Target;Morbidity - disease rate;neural;Neurons;Neurotransmitters;novel therapeutics;Nutrient;Nutritional;Octopamine;OmpR protein;Onset of illness;Organelles;Outcome;Output;Pathology;Pathway interactions;Pattern;Peripheral;peroxisome;Phosphorylation;Physiological;pleiotropism;prevent;Public Health;Regulation;Reproduction;reproductive;Research;response;Risk Factors;RNA Splicing;Role;sensor;side effect;Signal Transduction;SIRT1 gene;Sirtuins;SKI gene;System;Testing;Therapeutic;therapeutic target;Tissues;Transcription Coactivator;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Mechanisms Specific to the Beneficial Effects of Dietary Restriction

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Every 2-4 weeks, the outer layer of our skin, the epidermis, completely turns over and replaces itself, a finely tuned differentiation process that requires the precise regulation of gene expression by chromatin modifying enzymes. Any disruption of this well orchestrated process can drive the development of epidermal skin cancers, which collectively outnumber all other human cancers combined. This project will define the mechanisms through which dysfunction of chromatin modifiers can promote the initiation of cancer in the epidermis, so that we may ultimately harness the great potential of epigenetics-based therapies for skin disease in the future.

PI_NAMEs: CAPELL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Actinic keratosis;Aging;Area;Biological Models;cancer initiation;carcinogenesis;Cell Count;Cell Physiology;Cells;chemical carcinogenesis;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Clinical;Data;data integration;Development;dimethylbenzanthracene;Disease;Economic Burden;Economics;Enhancers;Enzymes;Epidermis;Epigenetic Process;epigenetic therapy;epigenome;epigenome editing;Epithelium;Functional disorder;Future;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome-wide;histone demethylase;Histone H3;histone methylation;histone methyltransferase;histone modification;Homeostasis;Human;human disease;human model;In Vitro;in vivo;Incidence;Individual;innovation;KDM1A gene;Keratin;Knock-in;Link;loss of function;Lysine;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;Methylation;Modeling;mouse model;Mus;Mutation;Neoplasms;novel therapeutics;overexpression;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;premalignant;prevent;Prevention strategy;Preventive;Process;Proliferating;Public Health;Regulation;Reporting;Repression;restoration;Role;Sampling;Skin;skin barrier;Skin Cancer;skin disorder;skin squamous cell carcinoma;sun damage;Technology;Testing;Therapeutic;transcription factor;transcriptome sequencing;Transgenic Mice;virtual

PROJECT_TITLE: Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE: This grant trains future leaders in cardiovascular disease prevention by providing rigorous training in epidemiology, biostatistics and related disciplines. The program benefits from the depth and breadth of courses, expertise, and research studies at Johns Hopkins. The faculty and training emphasize innovative methods and multidisciplinary work with an emphasis on prevention and decreasing disparities.

PI_NAMEs: SELVIN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TITLE: Cardiovascular Epidemiology Institutional Training

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative In order to improve quality of life and reduce societal costs of mental illness, there is a need to identify modifiable risk factors that contribute to increased vulnerability in order to inform new prevention and treatment programs. The current project is the first longitudinal study to examine how prenatal and childhood air pollution exposure impacts 1) neuroimaging biomarkers of corticolimbic circuitry involved in emotional processing and 2) subsequent risk of internalizing and externalizing psychopathology during the early adolescent period. By addressing these questions in a large, sociodemographic and geographic diverse sample of ~11,800 children across the U.S., findings from this study hold great promise for the potential to impact environmental health policy as well as identify early neuroimaging biomarkers of risk as potential targets for early intervention.

PI_NAMEs: HERTING, MEGAN MARIE (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;Adult;Affect;Affective;Age;Age of Onset;Aggressive behavior;Air Pollution;ambient air pollution;Amygdaloid structure;Anterior;Anxiety;anxiety symptoms;Attention deficit hyperactivity disorder;Axon;Behavior;Behavioral;behavioral impairment;Biological;blood oxygen level dependent;Brain;brain dysfunction;Brain region;Child;Childhood;Chronic;Cities;cognitive development;cohort;Data;Dendrites;density;depressive symptoms;design;Development;Diagnosis;Diagnostic;Diagnostic and Statistical Manual of Mental Disorders;diagnostic criteria;Dimensions;Disease;early adolescence;Early identification;Early Intervention;Emotional;emotional stimulus;Emotions;Enrollment;Environmental Health;Environmental Impact;Epidemiology;Exposure to;fine particles;follow-up;Functional Magnetic Resonance Imaging;Geography;gray matter;health data;Health Policy;Household Air Pollution;Human;improved;Individual;Inhalation Toxicology;interest;Intervention;Knowledge;Link;Literature;Long-Term Effects;Longitudinal Studies;Measures;Mediation;Mental Depression;Mental disorders;Mental Health;Methodology;modifiable risk;Morphology;multi-ethnic;multimodal neuroimaging;neural;neural circuit;Neurites;neurodevelopment;neuroimaging;neuroimaging marker;neurophysiology;neurotoxic;neurotoxicology;Neurotoxins;Nitrogen Dioxide;novel;Ozone;Patient Self-Report;Policies;pollutant;Population;postnatal;pre-clinical;prenatal;Prevention;Prevention program;Problem behavior;Psychopathology;Quality of life;Regulation;Research;Risk;Risk Factors;Role;Sampling;Signal Transduction;societal costs;sociodemographics;Stimulus;Structure;Testing;Time;Toxicology;treatment program;urban area;Visit;white matter

PROJECT_TITLE: The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Children who are HIV-exposed yet uninfected experience increased risk of infectious morbidity, mortality, poorer growth, neurobehavioral delays and deficits, and altered cardiometabolic health compared with children born to women without HIV. To understand the short- and long-term health of this rapidly expanding and large population, we will establish a cohort of 1,575 child-caregiver pairs in Botswana, a high burden HIV setting. We will enroll and follow 1,100 children who are HIV-exposed uninfected and 475 children HIV-unexposed uninfected ranging in age from birth to 17 years.

PI_NAMEs: JAO, JENNIFER ;MAKHEMA, JOSEPH MOEKETSI;POWIS, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 10 year old;15 year old;17 year old;3 year old;Acquired Immunodeficiency Syndrome;Adolescent;Adoption;Adverse effects;Africa South of the Sahara;Age;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;Biological;Birth;blood pressure elevation;Body mass index;Botswana;Breast;cardiometabolic risk;cardiometabolism;Caregivers;Central obesity;Cessation of life;Child;cohort;comparison group;Complex;Country;Data;data harmonization;Databases;Discipline of obstetrics;Disparity;Dyslipidemias;efavirenz;Enrollment;Epidemic;Epidemiologic Methods;experience;Exposure to;feeding;Frequencies;Future;Growth;Health;health disparity;Health Policy;Heterogeneity;High Prevalence;high risk;HIV;Home;immune activation;Impaired fasting glycaemia;improved;in utero;Individual;Infant;Infant Health;innovation;Insulin Resistance;Intervention;Intervention Trial;Life Cycle Stages;Link;low and middle-income countries;Maternal Health;Metabolic;Monitor;Morbidity - disease rate;mortality;neurobehavioral;Newborn Infant;Outcome;Participant;Passive Immunity;Pharmaceutical Preparations;Population;Pregnancy;Pregnant Women;prenatal exposure;Prophylactic treatment;Protease Inhibitor;Public Health;recruit;Regimen;Reporting;Research;Research Infrastructure;response;Risk;Risk Factors;Safety;School-Age Population;Seminal;sex;social;socioeconomics;Structure;therapy design;Treatment Protocols;Woman;Work;Youth

PROJECT_TITLE: FLOURISH - Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescent who are HIV Exposed Uninfected


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This is a new U01 application to establish a Clinical Center (CC) for a prospective multiethnic HFpEF cohort from California central valley for multiscale novel deep phenotyping analyses. Our proposed study promises to contribute both technically and conceptually to the overall understanding of the molecular mechanisms underlying the heterogenous disease in HFpEF.

PI_NAMEs: CADEIRAS, MARTIN ;CHIAMVIMONVAT, NIPAVAN  (contact);LOPEZ, JAVIER ENRIQUE

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Age;aging population;aging related disease;Agriculture;Area;Atrial Fibrillation;biomedical referral center;Blood flow;California;Cardiovascular Diseases;Cardiovascular system;career development;Catchment Area;Center for Translational Science Activities;Chronic Kidney Failure;Classification;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;cohort;college;community clinic;Community Hospitals;comorbidity;Complex;connectome;Coronary Arteriosclerosis;Country;Coupled;Data;Data Science;Data Set;Development;Diabetes Mellitus;Disease;EFRAC;electronic data;Electronic Health Record;Engineering;Enrollment;Environmental Science;Event;functional status;Funding;Genomics;Growth;Health Technology;Heart;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;Hypertension;Image;Incidence;indexing;Inflammation;Inflammatory;innovation;insight;Latino;Latino Population;Learning;Machine Learning;medical schools;Metabolic;Metabolic syndrome;metabolomics;mHealth;microbiome;Mining;minority communities;Molecular;Molecular Analysis;molecular targeted therapies;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;multiple omics;next generation;novel;Obesity;Organ;Participant;participant enrollment;patient engagement;patient population;Patients;Phase;phenomics;Phenotype;phrases;Plug-in;Population;Population Heterogeneity;Positron-Emission Tomography;preservation;programs;Progressive Disease;prospective;Proteomics;protocol development;Pulmonary Hypertension;Quality of life;Records;recruit;remote monitoring;Research;Research Institute;Research Personnel;Role;sex;skill acquisition;Source;Syndrome;Testing;Text;text searching;Therapeutic;United States;United States National Institutes of Health;Variant;web portal

PROJECT_TITLE: A prospective multiethnic HFpEF cohort from California's Central Valley


ORG_CITY: CHARLESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH The goal of the proposed project is the development of computational models for design and testing of novel nanoparticles for targeted drug delivery to cancerous tumors. If successful, the proposed computer models will enable the systemic evaluation of nanoparticles not possible with other experimental methods and may result in more efficient nanoparticle-based cancer therapies.

PI_NAMEs: HAEMMERICH, DIETER  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Animal Model;Animals;Anthracycline;Cancer Model;cancer therapy;Cancerous;Cardiac;Cells;chemotherapy;Clinical Trials;Complex;Computer Models;contrast enhanced;Data Set;design;Development;Dose;Drug Delivery Systems;drug distribution;Drug Targeting;Encapsulated;Evaluation;fluorescence imaging;Goals;health goals;Human;imaging modality;imaging study;improved;in vivo;in vivo imaging;in vivo Model;individualized medicine;innovation;Kinetics;Libraries;Light;Liposomes;Magnetic Resonance Imaging;Maps;mathematical model;Measures;Methods;model design;Modeling;Mus;nanoparticle;nanoparticle drug;nanopolymer;novel;novel therapeutics;Parameter Estimation;Patients;Perfusion;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physiology;Plasma;preclinical evaluation;predictive modeling;Property;Public Health;Reproducibility;Research Personnel;response;System;Testing;Therapeutic;Therapeutic Effect;Three-Dimensional Imaging;Tissues;Toxic effect;translational impact;Treatment Efficacy;treatment optimization;treatment planning;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;uptake;Validation;Vascular Permeabilities;virtual

PROJECT_TITLE: Computational model of targeted drug delivery

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Homologous recombination maintains genomic stability by providing high-fidelity repair of DNA double-stranded breaks and other types of complex DNA damage such as interstrand crosslinks. This DNA repair pathway has dual significance for cancer as genetic defects in recombination increase cancer predisposition and as the types of DNA damages it targets are induced by common DNA damage-inducing modalities in cancer treatment. The proposed work will contribute to an improved mechanistic understanding of recombinational DNA repair, which will also benefit novel personalized treatment approaches targeting recombination-deficient tumors.

PI_NAMEs: HEYER, WOLF-DIETRICH  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Abbreviations;anti-tumor agent;ATRX gene;Base Pairing;Biochemical;Biological;Biological Assay;Breast;cancer predisposition;cancer therapy;cancer type;Cells;Central Nervous System Neoplasms;Complex;crosslink;Cruciform DNA;Data;Defect;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;Drug Targeting;Enzymes;Event;Funding;Genetic;genetic approach;Genetic Recombination;Genome Stability;Genomic Instability;Goals;Homologous Gene;homologous recombination;Human;improved;In Vitro;insight;Invaded;Ionizing radiation;Lead;Length;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;Mediating;Metabolism;Modality;Modeling;Molecular;Motor;Mutation;novel;novel therapeutic intervention;Nucleotides;Outcome;Pathway interactions;personalized medicine;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Process;Proteins;Quality Control;RAD54L gene;Reaction;reconstitution;RECQL5 gene;Regulation;Research;Resolution;Role;Saccharomyces cerevisiae;Saccharomycetales;single molecule;Sister Chromatid Exchange;Structure;targeted treatment;Technology;Testing;Therapeutic;Time;Topoisomerase;tumor;Work;Yeasts

PROJECT_TITLE: Recombinational Mechanisms of DNA Repair

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: The proposed program will train predoctoral students at the University of California, Irvine in a broad array of disciplines related to virus-host interactions. The program provides a research- based setting that includes formal coursework, seminar programs, research symposia, training in the handling of DNA and RNA viruses, training in the responsible conduct of research, and original laboratory research. This comprehensive training is intended to equip Ph.D. students with the necessary intellectual and research tools required for their future health-related careers in biotechnology, academia (including teaching), the pharmaceutical industry, public health, and related disciplines.

PI_NAMEs: SEMLER, BERT L (contact);SHI, YONGSHENG

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Training Programs;virus host interaction

PROJECT_TITLE: Virus-host interactions: a multi-scale training program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE We will develop novel informatic methods to support continuous genomic reanalysis for patients with non- diagnostic exome/genome sequencing. These methods will enable the interoperability of computable phenotypes with existing phenotype-genotype association knowledge, automate genomic reinterpretation with up-to-date and diversity-aware phenotype and genotype (allele frequency) knowledge, and improve the accuracy, efficiency, and effectiveness of genomic diagnostics across diverse populations to reduce genomic health disparities.

PI_NAMEs: CHUNG, WENDY K;WANG, KAI ;WENG, CHUNHUA  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Age;Algorithms;Awareness;base;Case Study;Categories;Child;Clinical;clinical phenotype;clinical practice;clinical sequencing;Code;computable phenotypes;cost;cost effectiveness;Data;Databases;design;Development;Diagnosis;Diagnostic;digital phenotyping;Disease;disease phenotype;Disparity;Documentation;Effectiveness;Electronic Health Record;Ensure;Equity;Evolution;exome;exome sequencing;Face;Gene Frequency;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;genetic variant;genome sequencing;Genomic medicine;Genomics;Genotype;Germ-Line Mutation;Goals;Grain;health disparity;Healthcare;Healthcare Systems;improved;Individual;Informatics;innovation;insight;Institution;interoperability;KBG syndrome;Knowledge;knowledge graph;Laboratories;Learning;Literature;Manuals;Medical center;Medical Records;Methodology;Methods;multimodality;Natural Language Processing;Natural Language Processing pipeline;novel;open source tool;patient population;Patients;Pediatric Hospitals;Performance;phenome;Phenotype;Philadelphia;Physicians;Population;Population Heterogeneity;portability;precision medicine;Public Health;Publishing;Rare Diseases;Research;Retrieval;routine screening;Severities;Signal Transduction;Somatic Mutation;Source;Specialist;Structure;Symptoms;Syndrome;TAF1 gene;Testing;Time;tool;tv watching;Underrepresented Populations;Underserved Population;Universities;Variant;Walking;Work;World Health

PROJECT_TITLE: Fair Phenotype Annotation and Genomic Reinterpretation


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PHR: Narrative Clostridioides difficile infection (CDI) is the most common hospital acquired infection in the US and has been designated by CDC as one of the five antimicrobial resistance most “Urgent Threats” to public health. Failure of antibiotics to cure CDI we hypothesize is due to an immune response of patients to CDI that causes more harm than good. We propose to test if treatment can be improved by blocking the damaging immune response.

PI_NAMEs: PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Adoptive Transfer;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Bacteria;Biometry;CCR5 gene;CD4 Positive T Lymphocytes;Cells;Cessation of life;chemokine;Clinic;Clinical;Clostridium difficile;Colon;commensal bacteria;Communication;cytokine;Data;dextran sulfate sodium induced colitis;Disease;Ensure;enteric infection;Environment;Failure;fecal transplantation;Foundations;Frequencies;Gnotobiotic;gut microbiota;Human;IL17 gene;Immune;Immune response;Immunity;Immunology;Immunotherapy;improved;Infection;Infection prevention;Inflammation;Inflammatory Bowel Diseases;innovation;interleukin-23;Interleukin-6;Intestines;Knock-out;Knockout Mice;Leukocyte L1 Antigen Complex;Mediating;mesenteric lymph node;Microbe;microbiota;mortality;mouse model;Mucous Membrane;Mus;Nature;Neutralization Tests;neutralizing monoclonal antibodies;neutrophil;North America;Nosocomial Infections;Oligonucleotides;Pathology;patient response;Patients;peripheral blood;Population;Predisposition;prevent;programs;Proliferating;Public Health;Publishing;RANTES;receptor;recruit;Recurrence;recurrent infection;Relapse;relapse risk;Research;Research Personnel;Resolution;response;risk prediction;Role;Severities;Sodium Dextran Sulfate;success;T-Cell Depletion;Testing;Tissues;United States;Universities;Virginia;Work

PROJECT_TITLE: Role of Th17 in Severe and Recurrent C. difficile Infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: There are few effective therapeutic options for lung cancers that lack activating mutations in actionable receptor tyrosine kinases, and there is an urgent need to develop a better understanding of the biological basis of lung cancer growth and metastasis. On the basis of the preliminary results presented here, we postulate that lung cancer growth and metastasis is driven by a novel secretory pathway activated by TP53 mutations and mediated by a therapeutically actionable Golgi protein, Golgi reassembly and adhesion protein 55 kD (GRASP55). If proven true, these findings would advance our understanding of the mechanisms of lung cancer progression and may lead to new treatment strategies designed to target secretion in cancer.

PI_NAMEs: KURIE, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acceleration;Adenocarcinoma Cell;Adhesions;angiogenesis;antagonist;Autophagocytosis;Autophagosome;Binding Proteins;Binding Sites;Biogenesis;Biological;Body part;Bypass;cancer cell;Cancer Patient;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Clinical;cohort;Complex;Conditioned Culture Media;Dedications;design;Development;Docking;Ectopic Expression;Endoplasmic Reticulum;Environment;Enzymes;Genetic;Golgi Apparatus;GOLPH3 gene;GORASP2 gene;Growth;Human;Hydrophobicity;Immunosuppression;improved;inhibitor;insight;Knowledge;KRASG12D;Length;liquid chromatography mass spectrometry;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;metastatic process;Molecular;mouse model;Mus;mutant;Mutation;N-terminal;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenes;Pathway interactions;Peptide Signal Sequences;Peptide Transport;Pharmaceutical Preparations;pharmacologic;PIK4CB gene;Play;Primary Neoplasm;Process;programs;Property;protein complex;Protein Secretion;protein transport;Proteins;Receptor Protein-Tyrosine Kinases;Regulatory Pathway;Sampling;small hairpin RNA;small molecule;Stress;Surface;Testing;Therapeutic;therapeutically effective;therapy design;Tissues;tool;TP53 gene;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;tumorigenic;Vesicle;vesicle transport

PROJECT_TITLE: A pro-metastatic secretory pathway activated by p53 loss in lung cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]