ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Lytic cell death is a self-protection mechanism against pathogen infection or even cancer, but its dysregulation also results in various inflammatory diseases and tissue injuries. Plasma membrane rupture is the cataclysmic step in lytic cell death that further propagates the inflammatory responses. NINJ1 is a newly identified protein to be responsible for carrying out plasma membrane rupture, but its working mechanism is not clear. Glycine is a widely used additive in various ex vivo organ preservation solutions during organ transplantation for its cytoprotection effect. Glycine cytoprotection is recently demonstrated to be a result of inhibiting plasma membrane rupture. Our proposed studies aim to understand the structural basis of NINJ1-mediated plasma membrane rupture and its inhibition by glycine treatment. This research will have the potential of identifying novel therapeutic targets for various inflammatory diseases and informing the development of better cell preservation strategies or agents.

PI_NAMEs: DAI, XINGHONG  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Apoptotic;Binding;Bone Marrow;Cell Adhesion;Cell Death;Cell membrane;Cells;Cryoelectron Microscopy;Cytoprotection;Cytoprotective Agent;Development;Disease;Event;extracellular;Glycine;Glycine Agents;Host Defense;Infection;Inflammatory;Inflammatory Response;Light;Link;Lytic;Macrophage;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Molecular;Necrosis;new therapeutic target;Organ Preservation Solutions;Organ Transplantation;pathogen;Pathologic;Pattern;Play;preservation;prevent;Process;Proteins;Research;Role;Rupture;Signal Transduction;Stimulus;Structure;Testing;tissue injury

PROJECT_TITLE: Molecular basis of plasma membrane rupture in lytic cell death and its inhibition by cytoprotective agent glycine

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PI_NAMEs: CARPTEN, JOHN D. (contact)

PROJECT_TERMS: Address;Administrator;Area;Behavior;Behavioral Sciences;Benchmarking;Budgets;California;cancer genome;cancer genomics;cancer health disparity;Cancer Patient;Clinical;Collaborations;colon cancer patients;Colorectal Cancer;Communication;Communities;Comprehensive Cancer Center;Conflict (Psychology);Consent;Data;Data Set;Development;Diagnosis;Enrollment;Ensure;Epidemiology;Evaluation;experience;Foundations;Genetic Counseling;Genetic study;Genome;genome sciences;genome sequencing;Genomics;Germ Lines;Goals;Hispanic;Human Resources;implementation strategy;improved;International;Latino;Latino Population;Lead;Leadership;Link;Malignant Neoplasms;member;Mission;Modeling;Molecular;Monitor;National Cancer Institute;Office of Administrative Management;Oncology;Online Systems;Outcome;patient engagement;patient population;Patient Recruitments;Patients;Policies;Population;Principal Investigator;Procedures;Process;Program Evaluation;programs;Publications;Research;Research Personnel;Scanning;Scientist;Strategic Planning;Structure;success;Supervision;System;Testing;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Type IV pili (T4P) are bacterial appendages that are critical for behaviors including DNA uptake during natural transformation, biofilm formation, twitching motility, protein secretion, and virulence. Using several model organisms with emphasis on Acinetobacter species, we will characterize the fundamental mechanisms driving T4P dynamics, regulation, and function. This work will lay the groundwork for developing new methods to control or hinder T4P and the broad behaviors they elicit in diverse bacterial pathogens.

PI_NAMEs: ELLISON, COURTNEY KATHLEEN (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acinetobacter;appendage;Automobile Driving;Bacteria;Bacterial Pili;Behavior;behavior influence;Behavioral;Biochemical;Biological Process;Biology;Biophysics;Caulobacter crescentus;Cell surface;Cells;Cellular biology;Comparative Biology;Cues;DNA;Environment;experience;extracellular;Genetic;Goals;insight;Intracellular Space;mechanical properties;Methods;Microbial Biofilms;model organism;Molecular;molecular mechanics;Molecular Motors;Motility;nanomachine;Output;pathogenic bacteria;Pattern;Physical environment;Physiological;Physiology;Pilum;protein function;Protein Secretion;protein structure;Regulation;Research Design;response;Signal Transduction;Stimulus;Structure;Surface;System;Techniques;tool development;uptake;Vibrio cholerae;Virulence;Work

PROJECT_TITLE: Molecular mechanisms of physical interactions between bacteria and their surroundings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LENZ, HEINZ JOSEF  (contact)

PROJECT_TERMS: Accounting;Acculturation;Address;advanced disease;Advocate;Age;Age Years;Benchmarking;Biological;Blood specimen;California;Cancer Burden;cancer genomics;Cancer Patient;cancer type;Caribbean Hispanic;Caring;Cessation of life;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collection;colon cancer patients;Colorectal Cancer;Communication;Consent;Country;Data;data registry;Development;Diagnosis;Disparity;Distant;driver mutation;early onset colorectal cancer;Education;effectiveness evaluation;epidemiologic data;ethnic minority population;Ethnic Population;exome;Family;follow-up;Formalin;Genetic;Genetic Counseling;Genetic Research;genome sequencing;genome-wide;Genomics;Health Services Accessibility;High Prevalence;Hispanic;Hispanic Populations;Immigration;improved;improved outcome;Incidence;Individual;Informed Consent;interest;Knowledge;Latino;Malignant Neoplasms;men;metastatic colorectal;Mexican;Minority Groups;Modeling;Molecular;Molecular Profiling;mortality;Mutation;neoplasm registry;novel;Oncogenes;Paraffin Embedding;Participant;patient engagement;patient population;Patients;Pattern;personalized approach;Play;Population;Population Heterogeneity;population stratification;precision medicine;preference;Process;Provider;Quality of Care;Race;Recording of previous events;recruit;Rectal Cancer;Recurrence;Reporting;Research;Research Personnel;research study;Resources;Risk;Role;sociodemographics;Subgroup;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;transcriptome sequencing;Trust;tumor;tumor diagnosis;Tumor Tissue;Underserved Population;Use Effectiveness;Whole Blood;whole genome;Woman

PROJECT_TITLE: Participant Engagement Unit


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurosciences;Opioids;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narrative We know very little about the relationship between HIV and endogenous retroviruses in the brain. We propose to use a combination of newly developed technologies to investigate the implications of narcotics on endogenous retroviruses expression in the context of HIV latency in primary human microglia cells.

PI_NAMEs: MULDER, LUBBERTUS C (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Affect;Anatomy;Autopsy;Base Pairing;Biology;Brain;brain tissue;cancer type;CD4 Positive T Lymphocytes;Cell Differentiation process;cell immortalization;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Conserved Sequence;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Set;deep sequencing;Detection;differential expression;DNA Transposable Elements;Elements;Endogenous Retroviruses;Epigenetic Process;Event;Exposure to;Gene Expression Profile;Genetic Transcription;Genome;Genomics;Goals;high reward;high risk;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Human Characteristics;Human Genome;Immune system;Immunology;In Situ Hybridization;Individual;induced pluripotent stem cell;Infection;innovation;insight;integration site;Investigation;Knowledge;Link;Maps;Mass Spectrum Analysis;Methodology;Microglia;Mission;Molecular;multidisciplinary;Narcotics;Nature;Opiate Addiction;Opioid;opioid exposure;Patients;Peptides;Persons;Phase;Phenotype;Play;Productivity;protein expression;proteogenomics;Proviruses;Recording of previous events;Reporter;Reporting;Resolution;Retrotransposon;Retrovirus Proteins;RNA;Role;Shapes;Site;Sorting;Source;Substance abuse problem;Substance Use Disorder;Technology;Testing;Therapeutic Agents;Time;Tissues;transcriptome sequencing;vector;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: HERV proteogenomics of narcotic-driven HIV latency


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biomedical Imaging;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE In preclinical studies, we demonstrate the efficacy of an IL-23 blocking strategy to improve alcohol-related liver damage. Here, we will clinically translate these findings by first testing the safety and tolerability of guselkumab, an FDA-approved anti-IL-23 antibody, in patients with alcohol-associated liver disease. We will also assess biomarkers for guselkumab target engagement as well as early biomarkers of treatment response.

PI_NAMEs: KISSELEVA, TATIANA ;LOOMBA, ROHIT  (contact);MORRIS, SHELDON ROBERT

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Adult;Adverse effects;Affect;alcohol abuse therapy;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Anti-Inflammatory Agents;Antibodies;Antibody Therapy;Autoimmune;Biological;Biological Markers;Blocking Antibodies;Cause of Death;Cells;chronic liver disease;Cirrhosis;Clinic;Clinical;clinical development;Clinical Research;clinical trial analysis;Clinical Trials;Collagen Type I;commercialization;complement C3 precursor;cytokine;density;Dose;Drug Kinetics;early detection biomarkers;Enrollment;Family;Fatty acid glycerol esters;Fatty Liver;FDA approved;Fibrosis;first-in-human;Functional disorder;Funding;Future;Hepatic;Hepatocyte;Human;IL17 gene;improved;Inflammation;Inflammatory;inhibitor;interleukin-23;Interleukin-6;Interleukins;lipid biosynthesis;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver inflammation;liver injury;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Mediating;Mediator;medication safety;member;Meta-Analysis;Monoclonal Antibodies;mRNA Expression;Mus;Myelogenous;Myeloid Cells;Myofibroblast;novel;Organ;Participant;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Phase I Clinical Trials;phase I trial;phase II trial;phase III trial;Population;pre-clinical;preclinical study;prevent;Primary carcinoma of the liver cells;Principal Investigator;Production;Proliferating;Protons;Psoriasis;Publishing;receptor;Recording of previous events;Regimen;Research Infrastructure;response;Role;Safety;safety assessment;safety testing;Sampling;Schedule;Serum;Serum Markers;Severity of illness;Signal Transduction;Steatohepatitis;success;Testing;Therapeutic;Translating;treatment response;trial design;United States;Work

PROJECT_TITLE: Novel IL-23 inhibitor for the treatment of alcohol associated liver disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Traumatic Head and Spine Injury

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Brain injury directly suppresses the immune system through release of soluble factors that disrupt thymic homeostasis and dampens responses of the peripheral immune system long term. The nervous system is also connected to the thymus though neuronal connections. In this proposal, we will determine the exact mechanisms of immunosuppression during neurological injuries and elucidate the contribution of innervation and soluble factors to the overall immune state with the hope to reverse this immunosuppression and help patients with neurological diseases.

PI_NAMEs: AYASOUFI, KATAYOUN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Affect;anti-tumor immune response;Antigens;Atrophic;Biochemical;Bone Marrow;Bone Marrow Transplantation;Brain;Brain Injuries;carcinogenesis;CD4 Positive T Lymphocytes;Cell Count;Cells;Central Nervous System;central nervous system injury;Central Nervous System Neoplasms;Central Nervous System Viral Diseases;Chemicals;Child;Chronic;Clinic;clinically relevant;cohort;combat;Data;Defect;Denervation;Ensure;Etiology;Failure;Fractionation;Glioblastoma;Glioma;Goals;Health;Homeostasis;Hospitals;Immune;Immune response;Immune system;Immunity;immunodeficiency;Immunological Models;Immunologics;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapy;in vitro Assay;Inflammation;Injury;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Maps;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Molecular Weight;Morbidity - disease rate;mortality;nerve supply;Nervous System;Nervous System control;Nervous System Disorder;Nervous System Trauma;Neuroimmune;neuroimmunology;Neurologic;Neurological Models;Neurology;Neurons;novel;novel therapeutics;Opportunistic Infections;Organ;Parabiosis;Pathway interactions;Patients;Peripheral;primary lymphoid organ;programs;Proteins;Publishing;Rabies virus;Research;response;Role;Seizures;Serum;Spleen;Sterility;Stroke;stroke patient;success;supportive environment;Systems Development;T cell reconstitution;T memory cell;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;thymus transplantation;Time;Traumatic Brain Injury;Viral Encephalitis;Work

PROJECT_TITLE: Nervous system control and regulation of the immune system following neurological insults

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research

PI_NAMEs: CRAIG, DAVID W (contact)

PROJECT_TERMS: Address;Area;Automation;Behavioral Sciences;Bioinformatics;California;Cancer Biology;cancer genome;cancer genomics;Clinical;Clinical Data;clinical sequencing;clinically relevant;Collaborations;Collection;colon cancer patients;Colorectal Cancer;Communication;Communities;Complement;Copy Number Polymorphism;Data;data communication;Data Set;data sharing;Dedications;Detection;Development;Diagnosis;DNA analysis;DNA Integration;DNA Methylation;DNA methylation profiling;Emerging Technologies;Ensure;Epidemiology;Event;exome sequencing;experience;Feedback;flexibility;Foundations;Funding Opportunities;Gene Mutation;Generations;Genes;Genetic Counseling;Genome;genome sequencing;genome-wide;Genomic Data Commons;genomic profiling;Genomics;Germ Lines;Goals;Guidelines;Hispanic;implementation strategy;improved;Knowledge;Latino;Lead;Leadership;Malignant Neoplasms;Measurement;medical schools;member;Mission;Molecular;mRNA sequencing;next generation sequencing;novel;Office of Administrative Management;Oncology;patient engagement;patient population;Patient Recruitments;Patients;Performance;Population;Predictive Value;Process;prognostic value;Program Evaluation;Psyche structure;Publications;Quality Control;Reporting;Reproducibility;Research;research clinical testing;Research Institute;Resources;Scanning;Scientist;Services;Specimen;Strategic Planning;Structure;Supervision;Transcript;transcriptome sequencing;translational genomics;tumor;tumor DNA;tumor exome;Universities;Untranslated RNA;Validation;Variant;variant detection;Vision;whole genome;Work

PROJECT_TITLE: Genome Characterization Unit


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science (TRS), serving as a central hub for the TRS research community, is a critical mechanism for providing the U.S. Food and Drug Administration's Center for Tobacco Products with the timely and targeted information it needs to carry out its regulatory activities. CASEL will contribute to this objective by providing scientific and logistical leadership and coordination; facilitating collaboration; providing expertise in measurement and analytic methods; strengthening the development of TRS careers; and playing a central and key role in dissemination of TRS research findings.

PI_NAMEs: MERMELSTEIN, ROBIN J.;STANTON, CASSANDRA A (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Acceleration;Achievement;Address;Adoption;Agreement;analytical method;Award;Behavior;career;career development;Centers for Disease Control and Prevention (U.S.);Collaborations;Communities;Complement;Consensus;Data;data sharing;Decision Making;Development;Directories;Discipline;Education;Ensure;Evaluation;evidence base;experience;Fostering;Funding;Goals;Grant;Health;Infrastructure;innovation;Institution;Leadership;Logistics;Marketing;Measurement;Measures;member;Mentorship;Methods;Mission;Play;Principal Investigator;Process;programs;Public Health;Research;Research Contracts;Research Personnel;Research Priority;Research Project Grants;Resource Development;Resources;response;Robin bird;Role;Science;Scientist;skills;special interest group;supportive environment;synergism;Time;Tobacco;tobacco products;tobacco regulatory science;Tobacco Surveillance;Training;U-Series Cooperative Agreements;United States Food and Drug Administration;United States National Institutes of Health;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R(50)R]


PI_NAMEs: ROSENTHAL, JEANNE  (contact)

PROJECT_TERMS: Acceleration;Address;Area;Collaborations;Communication;Communities;Community Networks;Data;Development;Ensure;Evaluation;experience;Funding;Goals;Group Structure;Infrastructure;Institution;Leadership;Learning;Logistics;meeting abstracts;meetings;multidisciplinary;Positioning Attribute;Procedures;Process;product development;programs;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Robin bird;Science;special interest group;Structure;Time;Tobacco;tobacco products;tobacco regulatory science;tool;Training;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science - Leadership and Logistics Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pain Research;Patient Safety;Primary Health Care;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: BUFFALO GROVE

ORG_NAME: BRIGHTOUTCOME INC.

ORG_STATE: IL

PHR: Project Narrative Chronic pain is associated with substantial suffering and other co-morbidities such as depression, insomnia, fatigue, lowered mobility, and worse quality-of-life. Most of the care of chronic pain patients occurs during hurried primary care visits with pharmacological treatments (e.g. opioids and medications) despite mixed evidence of efficacy and increased risk of potentially dangerous side effects, including addiction and death. Even when these treatments are effective in reducing pain, they may not improve mental and functional status. The need for easy access to evidence-based non-pharmacological treatment options that include patient information and skill building would be helpful to chronic pain patients. To address this need for non-pharmacological approaches to treating chronic pain, we propose developing the GEMINI platform to facilitate the delivery of online Integrative Medical Group Visits (IMGV) via video conferencing with evidence-based home practice and self-management tools covering such topics as mindfulness, mind-body practices, self-management of chronic pain, stress reduction, sleep, and nutrition. We hypothesize that the use of the GEMINI intervention would result in reduced pain impact, better pain-related patient outcomes, improved self-efficacy in pain management, and reduced pain medication use.

PI_NAMEs: GARDINER, PAULA MARIE;HAAS, NIINA M. (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: 2 arm randomized control trial;addiction;Address;Adherence;Adult;Affect;Analgesics;Anxiety;arm;base;Caring;Cessation of life;Chronic Care;chronic pain;chronic pain management;chronic pain patient;Clinical Research;Code;cohort;commercialization;Communities;comorbidity;Complementary Health;Computer software;Control Groups;COVID-19 pandemic;Dangerousness;design;Development;digital health;evidence base;Fast Healthcare Interoperability Resources;Fatigue;Feedback;Fees;functional status;Health Services;High Prevalence;Home;improved;innovation;Integrative Medicine;Internet;Intervention;low health literacy;Low income;Marketing;Measures;Medical;Medicare;Mental Depression;mental state;Mind;mind/body;mindfulness;Modeling;Monitor;Nonpharmacologic Therapy;nutrition;Office Visits;online delivery;Opioid;Pain;Pain management;pain outcome;pain reduction;pain self-management;pandemic disease;Patient Monitoring;Patient Self-Report;Patient-Focused Outcomes;patient-level barriers;Patients;peer;peer support;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;pilot test;Practice Management;preference;Preparation;prescription pain reliever;primary care visit;Privatization;product development;prototype;Provider;provider portal;Qualitative Methods;Quality of life;racial diversity;Randomized;Randomized, Controlled Trials;Research;Research Design;Research Personnel;response;Rewards;Risk;Role;Schedule;secondary analysis;Secure;Self Care;Self Efficacy;Self Management;side effect;skills;Sleep;Sleeplessness;Social Interaction;stress reduction;Support Groups;symptom self management;Symptoms;System;telehealth;Telephone;Testing;tool;Training;treatment arm;Update;usability;Videoconferencing;virtual;Visit;web platform

PROJECT_TITLE: GEMINI: Virtual Integrative Medical Group Visits  for Managing Chronic Pain


PI_NAMEs: STANTON, CASSANDRA A (contact)

PROJECT_TERMS: Address;Adoption;Area;Award;Budgets;Catalogs;Collaborations;Collection;Communities;Consensus;Consultations;Data Collection;data harmonization;Data Pooling;data repository;data sharing;Development;Electronic Nicotine Delivery Systems;Ensure;Evaluation;experience;Fostering;Funding;Funding Opportunities;Goals;Guidelines;Information Systems;innovation;Lead;Leadership;Logistics;Maps;Measures;member;Methodology;Methods;Mission;Nicotine Dependence;PhenX Toolkit;Population Assessment of Tobacco and Health;Positioning Attribute;Process;programs;Protocols documentation;Recommendation;repository;Research;Research Personnel;Research Priority;Research Project Grants;Resource Development;Resources;response;Role;Schedule;Science;scientific hub;special interest group;standard measure;Structure;Techniques;Terminology;Time;Tobacco;tobacco products;tobacco regulatory science;Tobacco Surveillance;Tobacco use;tool;Training;United States Food and Drug Administration;webinar;Work

PROJECT_TITLE: Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science - Analysis and Rapid Response Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: BAEZCONDE-GARBANATI, LOURDES A. (contact)

PROJECT_TERMS: Acculturation;Address;Area;Attitude;Belief;Biological;California;Cancer Etiology;cancer genomics;Cause of Death;Cessation of life;Client satisfaction;clinical trial participant;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Communication;community advisory board;Community Health Aides;Conflict (Psychology);Consent;County;Cross-Sectional Studies;Data;Data Analyses;Disparity;Education;Educational Assessment;empowerment;Enrollment;Evaluation;evidence base;Evolution;Exhibits;experimental study;Feedback;Focus Groups;follow-up;Fostering;Foundations;genetic counselor;Genomics;health literacy;Hispanic;Hospitals;improved;Informed Consent;Interviewer;Investigation;Knowledge;Language;Latino;Latino Population;literacy;Los Angeles;low socioeconomic status;Malignant Neoplasms;mathematical ability;Medical center;meetings;men;metastatic colorectal;Molecular;Newly Diagnosed;Oncologist;Participant;patient engagement;Patient Recruitments;Patient-Focused Outcomes;Patients;Population;primary outcome;Process;process optimization;Provider;psychological distress;Quality of Care;randomized trial;recruit;Research;Research Personnel;Role;secondary outcome;study population;Surveys;Survival Rate;Survivors;Testing;tool;treatment response;tumor;United States;virtual;Woman

PROJECT_TITLE: Engagement Optimization Unit


ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative – Overall Center There continues to be an urgent need for antiparkinsonian treatments that are more effective and have fewer side effects than those currently available. To address this need, the animal and human research of the proposed Center will focus on generating a more detailed understanding of the pathophysiology of Parkinson's disease, especially the poorly understood abnormalities of cortical activity in the parkinsonian state, and on using this knowledge to develop or optimize therapeutic approaches to Parkinson's disease. Apart from conducting highly collaborative and innovative research on Parkinson's disease, the Center will also train young investigators, and educate the public about Parkinson's disease research.

PI_NAMEs: WICHMANN, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Administrator;Affect;age group;Algorithmic Analysis;American;Anatomy;Animals;Area;Basal Ganglia;Basic Science;Behavior assessment;Behavior Control;biomedical referral center;Brain;career;Caregivers;catalyst;Cell Nucleus;Cells;Cerebral cortex;Clinic;Clinical;clinical care;Clinical Sciences;clinical translation;Collaborations;collaborative environment;Communication;Communities;Community Outreach;connectome;Corpus striatum structure;Data Analyses;data sharing;Deep Brain Stimulation;design;Development;Disease;Dopaminergic Agents;Education;Education and Outreach;Educational Activities;Electrocorticogram;Electroencephalography;Event;experience;experimental study;Fostering;Foundations;Functional disorder;Funding;General Population;Goals;Grant;Human;Human Resources;Image;in vivo;Information Centers;innovation;insight;Institution;interest;intervention effect;Journals;K-12 student;Knowledge;laboratory experience;Levodopa;Logistics;Mission;Modeling;Monkeys;Morphology;Motor;motor control;Motor Cortex;Movement Disorders;neural;Neurons;Neurosciences;nonhuman primate;outreach;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Patients;Pattern;Persons;Physiology;Population;Postdoctoral Fellow;Primates;programs;Recommendation;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Rodent;Role;science education;Scientist;Series;Services;side effect;Signal Transduction;Slice;Social Workers;Societies;statistical service;Structure;Students;symptom treatment;Synapses;Therapeutic;Therapeutic Intervention;Tissue Sample;Training;Translational Research;treatment optimization;Universities;virtual;voltage;web site;Work

PROJECT_TITLE: Morris K. Udall Centers of Excellence for Parkinson's Disease Research at Emory University


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Recent advances in biotechnology and computing are unlocking complex model systems including single-cell morphological profiling and large-scale virtual screening for pharmacology discovery. To get the most out of these complex model systems, my group develops machine learning and statistical methods to infer the causal mechanisms. Two projects that embody this work include modeling how spatial factors explain and confound cellular morphology and mapping bioactive chemical space to guide adaptive virtual screening.

PI_NAMEs: O'MEARA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Binding Sites;Biological;Biological Models;biological systems;Biotechnology;Cell Communication;Cell model;Cells;Cellular Morphology;Chemicals;Complex;cost;Cultured Cells;deep learning model;Development;drug discovery;Environment;Ethics;Failure;Fluorescent Dyes;high dimensionality;improved;Individual;interest;Learning;Libraries;Ligand Binding;Ligands;machine learning method;Maps;Methods;Microscope;Modeling;Molecular;Morphology;new technology;Organoids;Pharmacology;programs;Research;Research Personnel;response;Robotics;screening;Selection Bias;simulation;Statistical Data Interpretation;Statistical Methods;System;three dimensional cell culture;timeline;Training;Translations;virtual;virtual screening;Work

PROJECT_TITLE: Learning How to Give Casual Explanations for Large Scale Virtual and Morphological Pharmacology


PI_NAMEs: STROUP, ANDREA M (contact)

PROJECT_TERMS: Academia;Active Learning;Address;Area;career;Career Choice;career development;career networking;Collaborations;Communication;Communities;Competence;curriculum enhancement;Development;Education;education resources;Educational Curriculum;Ensure;Evaluation;Event;experience;Exposure to;Feedback;Fostering;Funding;Grant;Infrastructure;innovation;Institution;Interdisciplinary Study;Journals;Knowledge;knowledge base;Leadership;Logistics;meetings;Mentors;Mentorship;Persons;Positioning Attribute;Postdoctoral Fellow;programs;Research;Research Personnel;Research Priority;Research Project Grants;Resource Development;Resources;Role;Science;Scientist;Seasons;Series;skills;special interest group;Students;Tobacco;tobacco products;tobacco regulatory science;Training;United States Food and Drug Administration;United States National Institutes of Health;virtual;Vocational Guidance;web site;webinar;Work;Writing

PROJECT_TITLE: Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science - Career Enhancement Core


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE (Overall) The overall goal of the UMN Udall Center is to define the changes in brain circuitry that underlie motor and cognitive dysfunction in Parkinson’s disease and use this information to improve current and develop new deep brain stimulation therapeutic approaches. The UMN Udall Center will integrate neuroimaging, neurophysiology, and deep brain stimulation techniques to improve the lives of patients suffering from Parkinson’s disease.

PI_NAMEs: VITEK, JERROLD L (contact)

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Acute;Affect;Algorithms;Animals;Awareness;Basal Ganglia;Biological Markers;Biostatistics Core;Bradykinesia;brain circuitry;Brain region;Brain Stem;career;Caring;catalyst;Chronic;Clinical;Cognitive;cognitive function;cognitive impairment in Parkinson's;cohort;Communities;community engagement;Complement;Computer Models;Coupling;Data;data management;Data Management Resources;data quality;Databases;Deep Brain Stimulation;Development;Diffusion Magnetic Resonance Imaging;Dopa;Dyskinetic syndrome;Electrocorticogram;Electrophysiology (science);Equilibrium;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Gait;Gait abnormality;General Population;Globus Pallidus;Goals;Human;Image;implantation;improved;Individual;Infrastructure;insight;Lead;Leg;Levodopa;Location;Magnetic Resonance;Magnetic Resonance Imaging;Mediating;Midwestern United States;Minnesota;Modeling;Monitor;Motivation;Motor;Motor Cortex;motor disorder;motor symptom;MPTP model;MPTP non-human primate;multimodal data;National Institute of Neurological Disorders and Stroke;neural circuit;neuroimaging;neurophysiology;Neuropsychology;next generation;nonhuman primate;novel;Operating Rooms;Outcome;outreach;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patient Education;Patient Recruitments;Patients;Pattern;Physiological;Postoperative Period;Prefrontal Cortex;Property;Quality Control;Research;Research Personnel;Research Support;Resistance;Resolution;Rest;Role;sensor technology;Sensory;Severities;Site;statistical and machine learning;Structure of subthalamic nucleus;symposium;symptomatology;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Translations;treatment optimization;United States National Institutes of Health;Universities

PROJECT_TITLE: Circuit-based deep brain stimulation for Parkinson's disease


PROJECT_TERMS: Academic support;Administrator;Algorithmic Analysis;Applications Grants;Area;Awareness;Basal Ganglia;career;Caregivers;Clinic;Clinical;Collaborations;Communities;Community Outreach;Data;Dedications;Development;Education;Education and Outreach;Educational Activities;Educational process of instructing;Ensure;Event;Faculty;Financial Contribution;Fostering;Funding;graduate student;Grant;Group Meetings;Health Personnel;Human Resources;informal learning;Institution;Journals;Laboratories;Learning;lectures;medical schools;meetings;member;Mentors;Mission;Movement Disorders;Neurology;Neurosciences;neurosurgery;organizational structure;outreach;outreach program;Parkinson Disease;Participant;Patients;Persons;Postdoctoral Fellow;programs;Progress Reports;Recurrence;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Series;Services;student participation;Students;Support Groups;System;Technology;Tissue Sample;Training;Training Activity;Training and Education;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Vocational Guidance;web site;Work;Writing


PROJECT_TERMS: Acceleration;Area;authority;Collaborations;Communication;Communities;Data;Databases;Educational Materials;Educational workshop;Electronic Mail;Ensure;Evaluation;Event;experience;Exposure to;Feedback;Fostering;Funding;Funding Opportunities;Goals;improved;Information Dissemination;Infrastructure;innovation;journal article;Journals;Knowledge;Logistics;Manuscripts;meeting abstracts;meetings;Mission;news;novel;Occupations;Paper;Peer Review;Policies;Policy Maker;Positioning Attribute;Process;Publications;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Role;Science;Scientist;Secure;Series;Slide;social media;Source;symposium;System;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco Surveillance;tool;Training;United States Food and Drug Administration;Update;uptake;user-friendly;Visual;Visualization;web site;webinar;Work

PROJECT_TITLE: Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science - Dissemination Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative TBCK-encephaloneuronopathy is a recently described genetic disorder that causes intellectual disability, seizures, and weakness in children across the world. Most of the children affected to date are Puerto Rican and suffer progressive neurodegeneration that leads to premature death. Elucidating how the loss of the TBCK protein leads to neurodegeneration- particularly by examining the novel concept that RNA transport defects preferentially impair axonal mitochondria- may provide insight into the mechanisms underlying neurodegeneration regardless of age, and may help develop new therapies for this devastating disease.

PI_NAMEs: ORTIZ-GONZALEZ, XILMA R (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;Age;Amyotrophic Lateral Sclerosis;autosome;Award;Axon;Bioenergetics;Biological Assay;Cell Death;Cell Nucleus;Cessation of life;Child;Childhood;Complex;confocal imaging;Data;Defect;Developmental Delay Disorders;differential expression;Disease;Distal;Distant;DNA Sequence Alteration;Early Endosome;effective therapy;Encephalopathies;Endosomes;Environment;experimental study;Fibroblasts;Functional disorder;Genetic Diseases;Goals;Homeostasis;Human;Impairment;indexing;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Institution;Intellectual functioning disability;Knowledge;late endosome;Lead;Link;Lysosomes;Mediating;Membrane Potentials;Messenger RNA;Microfluidics;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Morphology;mRNA Translation;Mutation;NADP;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurologic;neuronal cell body;Neurons;new therapeutic target;novel;novel therapeutics;null mutation;Oxygen Consumption;Patients;Peptide Synthesis;Phenotype;Physicians;Physiological;Play;polypeptide;Population;Predisposition;premature;Production;programs;progressive neurodegeneration;Protein Biosynthesis;protein complex;Protein Import;Proteins;Proteome;Proteomics;Proxy;Public Health;Puerto Rican;Quality Control;rare genetic disorder;Reporter;Reporting;Research;respiratory;Ribosomes;RNA;RNA Transport;Role;Scientist;Seizures;Severities;single molecule;stem;Stress;superoxide dismutase 1;Testing;trafficking;Transcript;transcriptome;transcriptome sequencing;Translations;Visualization;Work

PROJECT_TITLE: Unraveling the Mechanisms of Neurodegeneration in TBCK Encephaloneuronopathy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Health Services;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PROJECT_TERMS: Accounting;Administrator;Advisory Committees;Advocacy;American;Basic Science;career;career development;catalyst;clinical care;cohort;Collaborations;collaborative environment;Communication;Communities;community engagement;Community Health;Community Outreach;conflict resolution;Decision Making;Deep Brain Stimulation;Development;digital;Doctor of Philosophy;Educational Status;Ensure;Facebook;Family;Foundations;General Population;Health;health care service organization;IACUC;Individual;Institution;Institutional Review Boards;Integrated Health Care Systems;Lead;Leadership;Life Cycle Stages;Mediating;meetings;Mentors;Mentorship;Minnesota;Mission;Monitor;National Institute of Neurological Disorders and Stroke;next generation;outreach;Parkinson Disease;Pathway interactions;Patients;Performance;Persons;Policies;posters;Program Development;Progress Reports;Publications;Regulation;Research;Research Personnel;Resource Allocation;Resources;Students;Support Groups;symposium;Translational Research;Translations;Twitter;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Administrative Core


PI_NAMEs: GALVAN, ADRIANA  (contact)

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Acute;Anatomy;Animal Experiments;Animal Model;Animals;Behavior;Behavior assessment;Behavioral;biocytin;Bioinformatics;Biometry;Brain;brain tissue;Caring;Cells;Chronic;Clinical;Conceptions;Consultations;Data;Data Analyses;data sharing;Denervation;digital imaging;Dopamine;Dose;Electrodes;Electrophysiology (science);Evaluation;experience;experimental analysis;Experimental Designs;experimental study;Feedback;Genes;Health Services Accessibility;Histologic;Histological Techniques;Histology;Human Resources;Image Analysis;Immunohistochemistry;Injections;instructor;Levodopa;light microscopy;Location;Macaca mulatta;Methods;Microscopy;Modeling;Monkeys;MPTP model;MPTP treatment;Mus;Nervous System Disorder;Neurotoxins;Opsin;optical fiber;optogenetics;Oxidopamine;Parkinson Disease;parkinsonian animal;Parkinsonian Disorders;parkinsonian non-human primate;Pattern;Penetration;Procedures;Process;professor;Proteins;Public Health Schools;reconstruction;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Risk;sensor;Services;Spinal;Standardization;Statistical Data Interpretation;statistical service;Techniques;Testing;Time;tissue processing;Tracer;transgene expression;Transgenes;Universities;Viral Vector;Virus;voltage

PROJECT_TITLE: Research Services Core


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: RENO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: The product of this research will immediately provide new, critical, and fundamental knowledge on the relative importance of mitochondrial fission adapter proteins for synaptic function. Furhter, this project will elucidate the reasons why dysfunction in the mitochondrial fission protein DRP1 is more severe than loss of mitochondrial fission adapters: we posit that DRP1 facilitates synaptic vesicle biogenesis, independent of its function in mitochondrial fission. Pursuit of this knowledge is important, as DRP1 has been identified as a therapeutic target to alleviate core causes of aging and neurodegenerative diseases such as Alzheimer’s Disease. The motivations for this project are to increase our basic science knowledge of synaptic function in the brain, and also enhance healthspan in populations increasingly subject to age-related neurological diseases.

PI_NAMEs: RENDEN, ROBERT B (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Adjuvant;Affect;age related;Aging;Alzheimer's Disease;Basic Science;Biogenesis;Biological Models;Brain;Cell membrane;Cell Physiology;Cell Survival;Cells;Cellular Stress;Chronic;Collaborations;Data;Defect;Development;Disease;Disease Progression;Dissection;Dynamin;Dynamin III;Electric Capacitance;Electron Microscopy;electron tomography;Electrophysiology (science);Embryo;Endocytosis;Environment;Excision;Excitatory Synapse;Fluorescence;Functional disorder;functional restoration;Gene Transfer Techniques;Glutamates;Goals;Health;healthspan;Homeostasis;Human;Huntington Disease;Impairment;Intervention;Investigation;Knowledge;light microscopy;loss of function;Measurement;Mediating;Membrane;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;Motivation;Mus;nanoscale;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neurotransmission;novel strategies;Organism;Outer Mitochondrial Membrane;Phenotype;Plasma;Play;Population;postnatal;Preparation;presynaptic;presynaptic neurons;Presynaptic Terminals;Process;Protein Isoforms;Proteins;Reactive Oxygen Species;reconstruction;recruit;Recycling;Regulation;Research;Research Personnel;Resolution;Respiration;response;Retrieval;Role;Route;Shapes;Site;Slice;Stress;stressor;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Testing;Therapeutic;therapeutic target;Time;Tissues;Viral;Work

PROJECT_TITLE: Dynamin-related protein 1 and mitochondrial fission adapters regulate presynaptic function

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: HAREL, NOAM  (contact)

PROJECT_TERMS: Algorithms;Anatomic Models;Anatomy;automated segmentation;Axon;Basal Ganglia;Basic Science;Brain;catalyst;Clinical;cognitive function;Collaborations;Complement;Data;Databases;Deep Brain Stimulation;deep learning algorithm;denoising;Development;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Doctor of Philosophy;Electrodes;Foundations;Functional Magnetic Resonance Imaging;Generations;Globus Pallidus;Goals;Guidelines;Head;Human;Image;image processing;imaging capabilities;Implant;implantation;improved;in vivo;Individual;insight;International;Lead;Location;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Methods;Minnesota;Modeling;Motor;MPTP model;MPTP non-human primate;National Institute of Neurological Disorders and Stroke;Neural Pathways;neuroimaging;Neurosurgical Procedures;nonhuman primate;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;patient subsets;Patients;predictive modeling;Predisposition;Prefrontal Cortex;Recommendation;Research;Resolution;Rest;Scanning;side effect;Site;Space Perception;Structure;Structure of subthalamic nucleus;System;Techniques;tool;tractography;Training;ultra high resolution;Universities;Visualization;white matter;Work;X-Ray Computed Tomography

PROJECT_TITLE: UMN Udall Imaging Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Disability Research;Health Services;Neurosciences;Physical Rehabilitation;Rehabilitation;Social Determinants of Health;Telehealth

PHR: Project Narrative The pandemic’s new normal has changed access to healthcare. This research is relevant to public health and NIHCD mission as identification of access to healthcare/telehealth for people with hand spasticity will inform policy, clinical practice, targeted prevention efforts, enhance lives and optimizing abilities for all.

PI_NAMEs: BHIMANI, ROZINA  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Behavioral;Brain Injuries;Caregiver Burden;Caring;Cerebral Palsy;clinical practice;Communities;Computer Literacy;Computer software;Computers;Coronavirus;COVID-19 impact;COVID-19 pandemic;Data;dexterity;disability;Disabled Persons;Electronics;Emotional;experience;Future;General Population;Goals;Hand;Health;health care availability;health care delivery;health literacy;Health Services;Health Technology;Healthcare;improved;Individual;Individuals with physical disabilities;innovation;insight;Institutionalization;instrumental activity of daily living;interest;Intervention;Interview;Learning;Life;literacy;Lived experience;Loneliness;Methods;Minnesota;Mission;Modeling;Movement;Multiple Sclerosis;Muscle;National Institute of Child Health and Human Development;Neurologic;Occupational Therapist;pandemic disease;pandemic impact;Paralysed;Personal Satisfaction;Persons;Physical Function;Physicians;Policies;Population;post stroke;Prevention;Principal Investigator;Psychological Impact;Public Health;Quality of life;recruit;Rehabilitation Nursing;Rehabilitation therapy;Research;Research Personnel;social;Socialization;societal costs;spasticity;Spinal cord injury;Statistical Data Interpretation;Stroke;Structure;Technology;telehealth;tool;United States National Institutes of Health;Upper Extremity;Veterans;Work

PROJECT_TITLE: Identifying healthcare and telehealth access for people with hand spasticity

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: FACTOR, STEWART A (contact)

PROJECT_TERMS: Advertising;Affect;Age;Alzheimer's Disease;Appointment;awake;Behavior assessment;behavior test;Behavioral;behavioral outcome;Brain;Clinic;Clinic Visits;Clinical;clinical center;Clinical Research;Cognitive;cognitive change;cognitive testing;cohort;Collaborations;Collection;Communication;Computer Models;Data;Data Collection;data management;Databases;Deep Brain Stimulation;Documentation;Electrocorticogram;Electroencephalography;Electrophysiology (science);Enrollment;Ensure;Evaluation;executive function;follow-up;Functional disorder;Goals;Human Resources;Implant;implantation;Implantation procedure;improved;Impulsivity;Individual;Internet;Laboratories;Lead;Logistics;Motor;Neurocognitive;Neuropsychological Tests;Neuropsychology;Operative Surgical Procedures;Outpatients;Parkinson Disease;Participant;participant enrollment;Patient Recruitments;patient retention;Patients;Play;Prefrontal Cortex;Process;programs;recruit;Recruitment Activity;Research;Research Activity;Research Personnel;response;retention rate;Role;Schedule;Series;Services;sex;Signal Transduction;social media;Source;Structure of subthalamic nucleus;Study Subject;Techniques;Test Result;Testing;Travel;Universities;Visit;Work

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Natural Products;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Rehabilitation;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Despite opioid use after surgery, many patients still suffer from uncontrolled pain, and postoperative opioid use is associated with short- and long-term harmful outcomes. In this multi-site, 2x2 factorial, double-blind, randomized controlled trial, participants will receive one of four combinations of placebo or cannabidiol (CBD) for one week prior to surgery together with CBD or placebo for 4 weeks following surgery. This study will be the largest and most rigorous trial to assess whether perioperative CBD reduces opioid consumption after surgery, as well as pain, anxiety, sleep disturbance, and inflammation.

PI_NAMEs: BOEHNKE, KEVIN FOXMAN;BRUMMETT, CHAD M (contact);GAGNIER, JOEL JOSEPH

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Acute Pain;addiction;Adverse event;Affect;Age;American;Analgesics;Animals;Anti-Anxiety Agents;Anti-Inflammatory Agents;Anxiety;anxiety reduction;Arthritis;Cannabidiol;Cannabinoids;Cessation of life;Childhood;Chronic;chronic pain;Client satisfaction;Clinical;Clinical Research;clinical trial protocol;Clinical Trials;Constipation;Controlled Clinical Trials;craving;design;Development;Dizziness;Dose;Double-Blind Method;Drug Kinetics;Epidiolex;Epilepsy;Flare;functional improvement;General Population;Good Manufacturing Process;Grant;Health Care Costs;Health system;Human;improved;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;Investigation;Investigational New Drug Application;Knee Osteoarthritis;knee replacement arthroplasty;Literature;Mediating;Medical;Meta-Analysis;Methodology;Modality;multimodality;Nausea;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;opioid exposure;Opioid Rotation;opioid sparing;opioid use;opioid use disorder;Outcome;Overdose;Pain;Pain management;pain reduction;Participant;Patients;Perioperative;Persons;Pharmaceutical Preparations;Placebo Control;Placebos;Postoperative Pain;Postoperative Period;postoperative recovery;pre-clinical;Pre-Clinical Model;preclinical study;primary outcome;Property;Randomized;Randomized, Controlled Trials;recruit;repaired;Reporting;Research;Research Design;Role;Rotator Cuff;Safety;Sample Size;secondary outcome;Severities;sex;side effect;Site;Sleep;Sleep disturbances;Source;Symptoms;systematic review;Testing;Tetrahydrocannabinol;Therapeutic Effect;Translating;United States;United States Food and Drug Administration

PROJECT_TITLE: Cannabidiol for postoperative Opioid Reduction in primary total Knee arthroplasty – a randomized, 2x2 factorial, double-blind, placebo-controlled clinical trial (The CORK trial)

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation;Telehealth

PI_NAMEs: EBERLY, LYNN E (contact)

PROJECT_TERMS: Address;Adverse event;Biological Markers;Biostatistics Core;career;career development;catalyst;Cellular Phone;Clinical;Clinical Data;Cognitive;Collaborations;Communication;Communities;Complex;Data;Data Analyses;Data Collection;data integration;data management;Data Management Resources;data pipeline;data quality;data sharing;Database Management Systems;Databases;Deep Brain Stimulation;design;Development;Dimensions;Disease;Education;Ensure;Ethics;follow-up;Fostering;Foundations;Functional disorder;Funding Opportunities;Human Resources;human subject;Image;Information Dissemination;innovation;insight;interest;Knowledge;Leadership;Logistics;Measures;Mentors;Mission;Modeling;Modernization;Monitor;Motor;motor disorder;multidimensional data;multiple data sources;National Institute of Neurological Disorders and Stroke;Neurocognitive;neurophysiology;novel;Outcome;Parkinson Disease;participant safety;Patients;Postdoctoral Fellow;programs;Quality Control;recruit;remote assessment;repository;Reproducibility;Research;research data dissemination;Research Design;Research Personnel;Research Priority;Resources;Retrieval;Safety;Secure;Services;statistical and machine learning;Students;Sum;symposium;Symptoms;System;Telemedicine;training project;web site;Work

PROJECT_TITLE: UMN Udall Biostatistics Core


PI_NAMEs: JAEGER, DIETER  (contact)

PROJECT_TERMS: Address;Area;Basal Ganglia;Behavior;Behavioral;behavioral study;Bilateral;Biophysics;Brain;cell cortex;cell type;Cells;Cervical spinal cord structure;Chronic;Closure by clamp;Color;Complex;Computer Models;Corpus striatum structure;Data;Dopamine;Electric Stimulation;Elements;expectation;experimental study;Food;Forelimb;Frequencies;Functional disorder;Future;Genetic;genetic manipulation;Globus Pallidus;Head;Human;Image;Impairment;Implant;Injections;Investigation;Label;Lesion;Link;locomotor tasks;median forebrain bundle;Mediating;Methods;Minority;Modeling;Motor;motor control;Motor Cortex;motor disorder;Motor output;motor symptom;mouse model;Movement;Mus;nerve supply;neural;Neuronal Dysfunction;Neurons;Outcome;Output;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Pathologic;Patients;Pattern;Performance;Population;Positioning Attribute;Preparation;Primates;Property;Protocols documentation;Pyramidal Tracts;Research;response;Rodent;Role;Signal Transduction;Silicon;Slice;Spinal Cord;Structure;Structure of subthalamic nucleus;Substantia nigra structure;Synapses;System;Task Performances;Universities;voltage;voltage clamp

PROJECT_TITLE: Cortical Connectivity and Activity Changes in Motor Preparation and Execution in 6-OHDA-Lesioned Mice


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Lung;Nutrition;Obesity

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Asthma among individuals who are overweight or obese tends to be more severe, possibly because of increased inflammation, insulin resistance, and elevated blood sugar. This project is piloting the use of metformin, a well-tolerated oral medication that treats these conditions, among individuals with elevated body mass index and asthma. This will allow us to determine if a major trial investigating the effect of metformin among patients with obesity-associated asthma is feasible and justified, which if successful, would represent a new treatment option to the millions of Americans with asthma and elevated body weight.

PI_NAMEs: MCCORMACK, MEREDITH C (contact);WU, TIANSHI DAVID

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adherence;adherence rate;Adipose tissue;Adopted;Adoption;Adult;airway hyperresponsiveness;Allergic;allergic airway inflammation;Allergic inflammation;American;American Lung Association;Animal Model;arm;Asthma;asthma exacerbation;asthmatic patient;atopy;Blood Glucose;Body mass index;Body Weight;Body Weight decreased;Characteristics;clinical care;Clinical Research;Clinical Trials;cohort;Collaborations;college;Confidence Intervals;Data;design;Diabetes Mellitus;Diagnosis;Disease;effective therapy;Enrollment;epidemiologic data;epidemiology study;experience;Futility;Glucose;Goals;Hyperinsulinism;improved;Individual;Inflammation;Insulin Resistance;Interleukin-6;Link;Macrophage;medication compliance;Medicine;member;Metabolic;Metabolic Diseases;Metabolic Marker;Metformin;Modality;Morbidity - disease rate;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;obese patients;obese person;Obesity;obesity-associated asthma;opportunity cost;Oral;Outcome;Overweight;Participant;patient oriented;Patients;people of color;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Physiological;Placebo Control;Population;pre-clinical;Prediabetes syndrome;primary outcome;pulmonary function;pulmonary function decline;Randomized;Recording of previous events;recruit;remote visit;Research Design;Research Methodology;Research Priority;Resistance;respiratory smooth muscle;Risk;Role;Safety;Site;success;Telemedicine;Testing;Titrations;translational study;Transportation;United States;Universities;virtual;Visit

PROJECT_TITLE: Metformin IN Asthma for overweight and obese individuals (MINA)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed research is aimed to determine whether insufficient energy production caused by an impairment of the Krebs cycle plays a role in methamphetamine use disorder. The project is relevant to the public health because there is no FDA-approved medication for methamphetamine use disorder while illicit use of methamphetamine and deaths from methamphetamine overdose are rising in the United States. Upon successful completion of the project, we will know whether a loss of function by three Krebs cycle enzymes leads to a deficit in neuronal energy in experimental rats with methamphetamine use disorder and whether upregulation of neuroprotective protein parkin can prevent relapse to methamphetamine use.

PI_NAMEs: MOSZCZYNSKA, ANNA  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;Addictive Behavior;Adenosine Triphosphate;alcohol use disorder;Alzheimer's Disease;Antioxidants;Area;attenuation;Behavior Therapy;Biogenesis;Brain;Cessation of life;Chronic;Citric Acid Cycle;Clinical Trials;Communities;Consumption;Country;craving;Data;Development;Disease;Dose;Down-Regulation;Drug Targeting;Drug usage;Energy Metabolism;Enzymes;FDA approved;Generations;Glutathione;Goals;Health;Height;high risk;Impairment;Individual;innovation;insight;Knock-out;Knowledge;Laboratories;loss of function;Maintenance;Mediating;Metabolic Pathway;Methamphetamine;methamphetamine exposure;Methamphetamine overdose;Methamphetamine relapse;methamphetamine use;Methamphetamine use disorder;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Motivation;multicatalytic endopeptidase complex;neurochemistry;Neurologic;Neurons;neuroprotection;neurotoxicity;new therapeutic target;novel;Nucleus Accumbens;opioid epidemic;opioid use disorder;Overdose;overexpression;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Parkin;Parkinson Disease;Participant;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Production;Property;Proteins;Proteomics;Public Health;Rattus;Relapse;relapse prevention;Reporting;Research;response;Rewards;Role;Self Administration;System;Testing;Therapeutic;Toxic effect;Transferase;translational impact;Ubiquitin;ubiquitin-protein ligase;United States;Up-Regulation;Work

PROJECT_TITLE: Investigating Parkin-mediated Neuronal Energy Maintenance in Methamphetamine Use Disorder

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: COOPER, SCOTT E (contact)

PROJECT_TERMS: Adverse event;Behavioral;Biological Markers;Biometry;Biostatistics Core;catalyst;Clinical;Clinical assessments;clinical center;Clinical Data;cohort;Collaborations;Common Data Element;Consent;Data;Data Element;Data Management Resources;Data Set;Dedications;Deep Brain Stimulation;Devices;Doctor of Philosophy;Dopa;Electrophysiology (science);Ensure;experience;follow-up;Future;Goals;Home;human subject;Image;Manufacturer;Marketing;Microelectrodes;Minnesota;Monitor;Motor;Movement Disorders;National Institute of Neurological Disorders and Stroke;Neurologic;Neuropsychology;Operating Rooms;Operative Surgical Procedures;Outcome;Parkinson Disease;participant enrollment;Patient Education;Patients;Physiological;Postoperative Period;programs;Protocols documentation;recruit;repository;Research;Resistance;Schedule;sensor technology;smartphone application;Standardization;success;Symptoms;Time;Universities;wearable device;Work

PROJECT_TITLE: UMN Udall Clinical Core


PROJECT_TERMS: Affect;Agreement;Algorithms;Anatomy;Area;Basal Ganglia;Biological Markers;Bradykinesia;Cells;Clinical;Cognition;Cognitive;cognitive function;Cortical Synchronization;Coupling;Decision Making;Deep Brain Stimulation;Development;Devices;Disease;effective therapy;Electrocorticogram;Electrophysiology (science);Frequencies;Functional disorder;Future;Globus Pallidus;Goals;High Frequency Oscillation;high resolution imaging;Imaging Techniques;improved;Individual;insight;Lead;Levodopa;Location;Maps;Microelectrodes;Motor;motor disorder;Movement;Neurodegenerative Disorders;Neurons;Outcome;Parkinson Disease;Pathologic;Patients;Pattern;Performance;Persons;Phase;Phenotype;Physiological;Play;Postoperative Period;Prefrontal Cortex;Preparation;Rest;Role;Sensory;Severities;Shapes;Short-Term Memory;Site;STN stimulation;Structure of subthalamic nucleus;Therapeutic

PROJECT_TITLE: Pathophysiology-based approaches to deep brain stimulation for Parkinson's disease


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hydrocephalus;Neurosciences;Patient Safety;Rare Diseases;Sleep Research

ORG_CITY: EVANSTON

ORG_NAME: RHAEOS, INC.

PHR: Long-term cerebrospinal fluid dynamics in patients with shunted hydrocephalus during sleep and while performing activities of daily living (ADL) are clinically and scientifically important to identify and diagnose shunt failure, identify underlying causes, and evaluate the success of surgical revision procedures. However, they remain largely unknown owing to a lack of a direct monitoring technology to noninvasively measure flow through shunts, especially through periods of sleep. In this proposal, Rhaeos will undertake quality-controlled product development (UG3 phase) of the first sensor capable of continuous flow measurements over extended periods (~1 week) in remote monitoring settings, followed by a n = 20 patient NSR-feasibility study (UH3 phase) to evaluate device performance and safety.

PI_NAMEs: WEBB, RICHARD CHAD (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Activities of Daily Living;Address;Admission activity;Affect;Ambulatory Monitoring;American;arm;Blinded;Brain;Cardiac;Caring;Catheters;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid flow;Cessation of life;Clinical;Clinical Data;Clinical Research;Clinical Trials Design;Coma;Computer software;cost estimate;Data;Data Set;design;Development;Development Plans;Device Safety;Devices;Diagnosis;Diagnostic;diagnostic tool;Distal;Drainage procedure;Emergency department visit;Ensure;Failure;Family;Fatigue;Feasibility Studies;fluid flow;Functional disorder;glymphatic system;Goals;Greater sac of peritoneum;Headache;Home;Hospitalization;Hospitals;Hour;Hydrocephalus;Implant;implantation;improved;Inpatients;insight;Institutional Review Boards;Intuition;Knowledge;Left;Length;Lethargies;Live Birth;Magnetic Resonance Imaging;manufacturability;manufacture;manufacturing run;Maps;Measurement;Measures;meetings;miniaturize;Monitor;Nature;Nausea;Neurologic;Operative Surgical Procedures;Outsourcing;Patient Care;Patients;Performance;Phase;Polysomnography;pressure;Procedures;product development;Protocols documentation;Psyche structure;remote monitoring;Research;Safety;Second Look Surgery;Seizures;sensor;Series;Shunt Device;Site;Skin;Sleep;sleep pattern;software development;Spottings;subcutaneous;success;Symptoms;System;Technology;Testing;tool;Tube;United States;Universities;usability;user-friendly;Ventricular;Washington;wearable device;wireless;wireless sensor;X-Ray Computed Tomography

PROJECT_TITLE: Development of wireless, wearable flow sensors for continuous, long-term tracking of cerebrospinal fluid dynamics in patients with hydrocephalus

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Address;Affect;Anatomy;Animal Model;Animals;Area;arm movement;Autopsy;Basal Ganglia;Behavior assessment;Behavioral;Benserazide;Bradykinesia;Brain;cell cortex;Cell Nucleus;Cervical spinal cord structure;Clinical;Clinical Treatment;Complex;Computer Models;Corpus striatum structure;Corticospinal Tracts;Data;Data Analyses;Deep Brain Stimulation;Dopamine;Dopamine Receptor;dopamine replacement therapy;Effectiveness;Electric Stimulation;Electrophysiology (science);experimental study;Family;Frequencies;Functional disorder;Genes;genetic approach;Human;human disease;Image;imaging study;information processing;Injections;Interneurons;Intervention;Levodopa;Link;Macaca mulatta;Monkeys;Motor;Motor Cortex;Motor Manifestations;Movement;MPTP Poisoning;Neurons;nonhuman primate;Opsin;Output;outreach;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Prediction of Response to Therapy;Primates;Protocols documentation;Publishing;Receptor Activation;Research;response;Rest;retrograde transport;Rodent;Service Statistics;Signs and Symptoms;Slice;Specific qualifier value;Standardization;Statistical Data Interpretation;STN stimulation;Structure;Structure of subthalamic nucleus;symptom treatment;Synaptic plasticity;Techniques;Thalamic structure;Universities;Virus;Work

PROJECT_TITLE: Parkinsonism-Related Changes in Activity of Cortical Projection Neurons in Monkeys


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative This application requests support to establish a new postbaccalaureate training program, the University of Oregon Program to Increase Resilience and Enhance Persistence in Biomedical Sciences (UO PREP Bio), to increase the number of students from underrepresented, underserved, and historically excluded within the biomedical sciences both within UO and nationwide. By offering intentional community building activities, individualized mentorship, engaging research experiences, and academic and professional development, UO PREP Bio aims to prepare students to be 1) competitive applicants for top biomedical PhD programs and 2) to succeed in a rigorous graduate training program, thereby increasing long-term retention and success of these scholars from underrepresented backgrounds. UO PREP Bio will empower students to achieve their academic and professional goals by using a multifaceted, mentored educational framework that allows students to build and develop core competencies in experimental knowledge and inquiry, professional skills, and scientific identity.

PI_NAMEs: BARBER, MATTHEW FREDERICK (contact);ROHLFS, RORI V

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: academic standard;Address;Admission activity;apprenticeship;aspirate;Biomedical Research;bridge program;career;Career Choice;Climate;cohesion;cohort;Collaborations;Communities;community building;Competence;Country;Creativeness;Data;Degree program;Demography;design;Development;Development Plans;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational Curriculum;Educational workshop;empowerment;Enrollment;Ensure;Environment;equity, diversity, and inclusion;Event;evidence base;Exclusion;experience;Experimental Designs;Faculty;Fostering;Funding;Goals;Graduate Education;Graduate Enrollment;graduate school;graduate student;Grant;Growth;Health;Individual;Institution;interest;Interview;Journals;Knowledge;Learning;Literature;meetings;Mentors;Mentorship;Methodology;Methods;Minority Groups;Mission;Modeling;Oregon;Participant;Pathway interactions;peer;Postbaccalaureate;Postdoctoral Fellow;Productivity;programs;promote resilience;Qualifying;Reading;recruit;Request for Applications;Research;Research Training;resilience;responsible research conduct;Schedule;Science;Scientist;Secure;Series;skills;Societies;Source;STEM field;Structure;Student Persistence;Students;success;summer program;Talents;Technical Expertise;Techniques;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Visit;Washington;Work;Writing

PROJECT_TITLE: UO PREP Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Digestive Diseases;Hematology;Pancreatic Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative This Liquid Biopsy Research Laboratory (LBRL) partnership team, led by PI Peter Kuhn (academic) and Co-I Rick Wenstrup (industry) of Epic Sciences, is advancing biologically informed liquid biopsy (LBx) technology to fill gaps in current clinical practice of early cancer assessment. The three scenarios addressed by the LBx are 1) peripheral blood LBx as a companion to mammography for the early assessment of breast cancer, 2) enhanced screening and diagnostic workup for pancreatic cancer through multi-omic capabilities to create a multi-modal LBx using peripheral blood and portal vein blood, and 3) a peripheral blood LBx as a substitute to bone marrow aspirate to diagnose myeloma precursor states and detect the transition to multiple myeloma to easily identify candidates for early treatment intervention.

PI_NAMEs: KUHN, PETER  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;Aqueous Humor;Ascites;automated algorithm;automated analysis;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Volume;Bone Marrow Aspiration;burden of illness;candidate identification;Cardiovascular system;Cells;Cerebrospinal Fluid;Clinical;clinical care;clinical implementation;clinical practice;clinically significant;cohort;Collaborations;Companions;Complement;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic Imaging;diagnostic strategy;Early treatment;Endoscopic Ultrasonography;Endothelium;Epithelium;Evolution;extracellular vesicles;FDA approved;Genomics;imaging platform;Immune;Immunofluorescence Immunologic;improved;Industry;Intervention;Laboratory Research;liquid biopsy;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammography;Mesenchymal;Metastatic breast cancer;Methods;Monoclonal gammopathy of uncertain significance;Morphology;multimodality;Multiple Myeloma;multiple omics;Neoplasm Circulating Cells;Newly Diagnosed;novel;pancreatic neoplasm;patient population;Patient Recruitments;Patients;peripheral blood;Plasma;Population;Portal vein structure;Procedures;prospective;Proteomics;Protocols documentation;Publishing;Research;Research Design;Research Project Grants;Resources;routine screening;Sampling;Science;screening;Screening procedure;Slide;Specificity;standard of care;technological innovation;Technology;technology validation;Testing;Time;tumor;Ultrasonography;Work

PROJECT_TITLE: Multi-modal Liquid Biopsy Early Assessment of Breast Cancer, Pancreatic Cancer, and Multiple Myeloma


PI_NAMEs: MACKINNON, COLUM D (contact)

PROJECT_TERMS: Activities of Daily Living;Adverse effects;Afferent Pathways;Anodes;Axon;Basal Ganglia;blood oxygen level dependent;Border Crossings;Bradykinesia;catalyst;Cathodes;Chronic;Clinical;Cognitive;Cognitive deficits;cognitive load;Computer Models;Corpus striatum structure;Deep Brain Stimulation;design;Disease;Disease Progression;dopamine replacement therapy;Dorsal;effective therapy;electric field;Electrical Stimulation of the Brain;experimental study;fall risk;falls;Freezing;Functional Magnetic Resonance Imaging;Gait;Gait abnormality;Globus Pallidus;Goals;Home environment;Impaired cognition;Impairment;Implant;improved;Individual;insight;Intervention;Lead;Leg;Levodopa;Location;Lower Extremity;Magnetic Resonance Imaging;Measures;Medial;Mediating;Monitor;Morbidity - disease rate;Motor;motor control;motor symptom;Movement;Musculoskeletal Equilibrium;neuroimaging;neurophysiology;nonhuman primate;novel;novel strategies;Parkinson Disease;Pathway interactions;Patients;Persons;Posture;posture instability;Quality of life;Research;Resistance;Rest;Severities;Signal Transduction;Site;Speech;Speech Intelligibility;STN stimulation;Structure of subthalamic nucleus;synergism;System;Upper Extremity;wearable device;wireless

PROJECT_TITLE: Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease


PI_NAMEs: SMITH, YOLAND  (contact)

PROJECT_TERMS: Address;Affect;Anatomy;Animal Model;Area;Axon;Basal Ganglia;Behavioral;Brain;Brain Stem;Cell Nucleus;Cells;Chronic;Complex;connectome;Corpus striatum structure;Data;Deafferentation procedure;Dendritic Spines;Dependovirus;Development;Disease;Dissection;dopaminergic neuron;Electron Microscopy;Electrons;Electrophysiology (science);experimental study;Face;Foundations;Functional disorder;Genetic;genetic approach;Glutamates;Goals;hippocampal pyramidal neuron;Image;Knowledge;Label;Laboratories;Light;Literature;Macaca mulatta;Maps;Methods;Microscopic;Midbrain structure;Modeling;Monkeys;Morphology;Motor;Motor Cortex;nerve supply;Neuronal Plasticity;Neurons;Neurotoxins;nonhuman primate;novel therapeutic intervention;Optics;Output;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathologic;Pathology;Patients;Pattern;Physiology;Population;Population Heterogeneity;Presynaptic Terminals;Prevalence;Primates;Property;Pyramidal Cells;Recombinant adeno-associated virus (rAAV);Research;Resolution;retrograde transport;Sampling;Scanning Electron Microscopy;Serotyping;Site;Source;Spinal Cord;Structure of subthalamic nucleus;Synapses;System;Techniques;Thalamic structure;Therapeutic;tool;Universities;Variant;vector;Vertebral column

PROJECT_TITLE: Connectome of Motor Corticofugal Neurons in Parkinsonian Monkeys


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE To effectively treat Alzheimer’s Disease (AD) in the future, it will be essential to diagnose it early, before massive loss of brain cells occurs. The retina, as an outgrowth of the brain, shows promise as a site for non- invasive and inexpensive detection of early AD pathological processes, providing a novel screening tool for at- risk populations. This proposal will provide a deep understanding of AD pathogenesis in the retina and the relationship to brain pathology, potentially identifying new therapeutic and diagnostic targets.

PI_NAMEs: KORONYO-HAMAOUI, MAYA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloidosis;astrogliosis;Autopsy;Axon;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Brain;brain cell;Brain Pathology;cell type;Cells;Cerebral Amyloid Angiopathy;Cerebrum;Clinical;Cognition;Cognitive;Cognitive deficits;cohort;Color;cranium;Data;Data Analyses;Data Science;Data Set;Dementia;Deposition;Development;Diagnosis;diagnostic strategy;Disease;Early Diagnosis;Early identification;effective intervention;Extravasation;Future;ganglion cell;glial activation;Gliosis;Goals;Grant;hippocampal atrophy;Human;Immunotherapy;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;insight;Lead;Link;Measures;Metabolic;Microglia;mild cognitive impairment;Mitochondria;Molecular;Molecular Profiling;Monitor;Morbidity - disease rate;mortality;mouse model;multimodal data;Multiomic Data;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;neurosensory;neurovascular;neurovascular unit;new therapeutic target;next generation;Non-Invasive Detection;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;optical imaging;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Pericytes;Phenotype;Photoreceptors;Platelet-Derived Growth Factor beta Receptor;Population;Populations at Risk;Positron-Emission Tomography;Process;protein oligomer;Proteomics;Research;resilience;Resolution;response;Retina;Retinal Diseases;retinal imaging;Screening procedure;Severities;Site;Spatial Distribution;Synapses;synaptic pruning;tau Proteins;Tauopathies;Tight Junctions;tool;transgenic model of alzheimer disease;uptake;validation studies;vascular abnormality;Vascular Diseases;Vision;Visualization;β-amyloid burden

PROJECT_TITLE: Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the Retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative In most rural areas of India, intervention for children with cleft lip and palate ends post-primary surgery and patients and their families accept poor speech outcomes as a consequence of the disorder. This is unfortunate as, many times, these speech problems are correctable via secondary surgery or speech therapy; however, the resources and professionals who provide these interventions are clustered in urban areas and those in rural regions are unaware that additional treatment is possible. We address this gap by developing an AI-based mHealth app to determine if a child with CLP would benefit from additional treatment to improve communication outcomes and to connect them with cleft-care teams in urban areas.

PI_NAMEs: BERISHA, VISAR ;SCHERER, NANCY J. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Age;Algorithms;American;Arizona;Artificial Intelligence;artificial intelligence algorithm;automated algorithm;burden of illness;Caring;Child;child services;China;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;Clinic;Clinical;Clinical Services;Collaborations;Communication;Community Health;Community Health Aides;Community Healthcare;craniofacial;Cues;Databases;design;Developed Countries;Development;disability;Disease;Education;Enrollment;Evaluation;experience;Family;Feedback;follow-up;Functional disorder;global health;Health Personnel;Health Services Accessibility;Hearing;Impairment;implementation study;Improve Access;improved;India;Intervention;Language;low and middle-income countries;Measures;Medical;Medical Research;mHealth;Mobile Health Application;multidisciplinary;Operative Surgical Procedures;Outcome;outreach;Parents;Pathologist;Patients;Performance;pharyngeal flap;post intervention;prediction algorithm;Process Assessment;Production;Protocols documentation;Quality of life;Questionnaires;recruit;Rehabilitation therapy;repaired;Reporting;Research Personnel;Resources;Rural;rural area;Rural Community;rural health clinic;Sampling;Services;skills;social;Speech;Speech Intelligibility;Speech Therapy;Statistical Data Interpretation;Surgical Flaps;Technology;tool;Training;Universities;urban area;usability;Validation;validation studies;Validity and Reliability;Work;World Health Organization

PROJECT_TITLE: Improving communication  outcomes in children with cleft palate in rural India


NIH_SPENDING_CATS: Arthritis;Neurosciences

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative The proposed research is relevant to public health because understanding how the brain processes incoming inflammatory signals during inflammation and arthritis and the degree to which it regulates the onset and progression of tissue damage is expected to guide the development of new types of treatments and diagnostics for inflammation by specifically targeting functional brain networks. Thus, the proposed work is pursuant to the NIH’s mission fostering basic, novel and creative discoveries and innovative research strategies in order to ultimately enhance health. 1

PI_NAMEs: CHAVAN, SANGEETA S.;TRACEY, KEVIN J (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Action Potentials;Afferent Neurons;Anxiety;Arthritis;bioelectronics;Biological;Brain;Brain Stem;cholinergic neuron;clinically relevant;Colitis;Communication;Creativeness;cytokine;Cytokine Signaling;Data;Deep Brain Stimulation;Development;Diabetes Mellitus;Diagnostic;Etiology;Exposure to;Fostering;Genetic;Genetic Techniques;Goals;Grant;Health;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Arthritis;Inflammatory Response;innovation;Interleukin-1;Ischemia;Maps;Mental Depression;Mission;Mus;Nerve;Nervous System;neural;neural circuit;neural network;Neuroimmunomodulation;Neurologic;Neurons;neurotransmission;Nociceptors;novel;novel therapeutics;optogenetics;Organ Transplantation;Output;Pathogenesis;Pathway interactions;Peripheral;Pharmacogenetics;Physiological;Play;Process;Production;Public Health;Reporting;Research;response;response to injury;Role;Sensory;Signal Transduction;Techniques;Tissues;TNF gene;Transcranial magnetic stimulation;Transgenic Mice;United States National Institutes of Health;Vagus nerve structure;Virus;Work

PROJECT_TITLE: Brain neural networks regulating inflammation

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: JOHNSON, MATTHEW DOUGLAS (contact)

PROJECT_TERMS: Affect;Algorithms;Attention;Attenuated;Basal Ganglia;Behavior;Behavioral;Brain;Cell Nucleus;Cells;Chronic;Clinical;Cognitive;Complement;Complex;Consumption;cost;Data;Data Analyses;Deep Brain Stimulation;Dimensions;disability;dopamine replacement therapy;Electrophysiology (science);Environment;Event;experimental study;Freezing;Frequencies;Gait;Gait abnormality;Globus Pallidus;Goals;Habenula;Human;improved;Lateral;Length;Levodopa;Maintenance;Maps;Medial;Methodology;Midbrain structure;Modeling;Moods;Motivation;Motor;motor control;motor symptom;Movement;MPTP treatment;neural;neural circuit;Neuroanatomy;Neurons;neurosurgery;nonhuman primate;noradrenergic;novel;Outcome;Output;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathologic;Pathway interactions;Pattern;Physiological;pre-clinical;Primates;Quality of life;Resistance;response;Rewards;Role;sensory stimulus;Signal Transduction;Specificity;stem;Stimulus;Structure;Structure of subthalamic nucleus;Surface;Testing;Thalamic Nuclei;Thalamic structure;Time;wireless

PROJECT_TITLE: Optimizing pallidofugal modulation of midbrain and thalamic nuclei for treating cognitive-motor signs of Parkinson's disease


NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Wnts are evolutionarily conserved ligands that signal at short range to regulate morphogenesis, cell fate and stem cell renewal. This application will provide a molecular understanding of the how Wnts are secreted from the endoplasmic reticulum to the cell surface by binding their dedicated transporter protein WLS. We have determined the atomic resolution structure of Wnt in complex with WLS, using cutting-edge single-particle cryo-electron microscopy and we propose to contribute additional structures as well as employ a range of biochemical and cell-based experiments to study how Wnts bind to WLS, are transported, and dissociate from WLS to reach their target cells for signaling.

PI_NAMEs: MANCIA, FILIPPO  (contact);VIRSHUP, DAVID M

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Adult;Affect;Autocrine Communication;Binding;Biochemical;Biological Assay;Carrier Proteins;Cell membrane;Cell surface;Cells;Chimera organism;Complex;Coupled;Cryoelectron Microscopy;Cysteine-Rich Domain;Data;Dedications;Destinations;Development;Diffusion;Dissociation;Endoplasmic Reticulum;exosome;experience;experimental study;Fab Immunoglobulins;Family;G-Protein-Coupled Receptors;glycosylation;Heterodimerization;Histidine;Homeostasis;Human;Hydrophobicity;In Vitro;inhibitor;insight;Intestinal Cancer;intestinal homeostasis;Intestines;Kidney;Lateral;Ligands;Lipid Bilayers;Lipids;Location;Membrane;Membrane Proteins;Membrane Transport Proteins;migration;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;Morphogenesis;Movement;Mutagenesis;palmitoleate;particle;Pattern;Polysaccharides;prevent;protein protein interaction;Proteins;Proteoglycan;Publishing;receptor;Resolution;Route;Signal Transduction;Site;stem cell division;stem cell niche;Structure;Surface;System;Technology;Testing;Tissues;Transferase;Transmembrane Domain

PROJECT_TITLE: Molecular Mechanisms of Wnt Transport


NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: MIOCINOVIC, SVJETLANA  (contact)

PROJECT_TERMS: Affect;Age;Area;Attention;Basal Ganglia;Behavior;behavior measurement;Behavioral;Behavioral inhibition;behavioral outcome;behavioral study;biophysical model;Biophysics;Brain;catalyst;Characteristics;Clinical;Clinical Research;Cognition;Cognitive;cognitive impairment in Parkinson's;Computer Models;Cues;Data;Deep Brain Stimulation;design;Devices;Disease;dopamine replacement therapy;electric field;Electrocorticogram;Electrodes;Electroencephalography;Electrophysiology (science);Emergency Situation;Evaluation;Evoked Potentials;executive function;experimental study;Frequencies;frontal lobe;Functional disorder;Gait;Impairment;Implant;implantation;Implantation procedure;improved;Impulsivity;Knowledge;Lateral;Lead;Levodopa;Location;Maps;Measurement;Measures;member;Methods;Motor;motor control;motor deficit;motor symptom;Movement;Neuropsychological Tests;Neuropsychology;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;patient oriented;patient subsets;Patients;Performance;Persons;Pharmaceutical Preparations;Physiology;Postoperative Period;predictive modeling;Prefrontal Cortex;Proactive Inhibition;Procedures;Process;Reactive Inhibition;recruit;Research;Resolution;response;Role;Sampling;Scalp structure;sex;side effect;Signal Transduction;STN stimulation;Structure of subthalamic nucleus;synergism;Task Performances;Testing;Universities

PROJECT_TITLE: “Cortical electrophysiology of response inhibition and implications for DBS therapy in patients


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Methamphetamine;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PEDIATRICS

PHR: UMN CTSI UM1 Project Narrative The University of Minnesota's Clinical and Translational Science Institute, together with its Partners and Collaborators, will find better, faster ways to bring scientific advances to real-world use. To do this, we will reduce research barriers, provide high-quality services for researchers, foster and train a diverse research workforce, broadly share findings, build sustainable relationships with our Minnesota communities, and more. This work, combined with our focus on health equity and impact, ultimately aims to make healthcare better for everyone.

PI_NAMEs: BLAZAR, BRUCE R (contact);CRAWFORD, PETER A;FAIR, DAMIEN A

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Academia;Academy;Acceleration;Achievement;Address;Adoption;Advocate;African American;anti-racism;Attention;Award;Bioinformatics;Biometry;Black race;career development;Child;Clinical Data;clinical implementation;Clinical Research;Clinical Sciences;cognitive function;Collaborations;Communities;community engaged research;community engagement;Community Health Aides;Community Medicine;community partnership;Contracts;cultural competence;Data;Data Collection;data management;data sharing;Databases;Decision Making;Development;Diverse Workforce;early childhood;Economics;Education;Electronic Health Record;Enrollment;Equity;equity, diversity, and inclusion;experience;Faculty;Fellowship;fetal methamphetamine exposure;Fostering;Guidelines;Health;health data;health equity;Health Information System;Health Policy;Health system;Healthcare;implementation science;improved;Incentives;Indigenous;Individual;Informatics;Information Systems;Informed Consent;Infrastructure;innovation;Institutional Racism;Investments;Knowledge;Latino;Leadership;Learning;Lesbian Gay Bisexual Transgender Queer;Link;Measures;Medical;Medicine;Mentored Clinical Scientist Development Program;Methodology;Methods;Minnesota;Modeling;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;novel;Nursery Schools;Participant;Pathway interactions;Patients;Personality Assessment;Population;Population Heterogeneity;Postdoctoral Fellow;Process;programs;Public Health Informatics;recruit;Research;research data dissemination;Research Design;Research Personnel;Research Support;research to practice;Resource Allocation;Resources;response;Rural Health;Rural health equity;satisfaction;Science;Scientific Advances and Accomplishments;Series;Services;skills;Strategic Planning;Structural Racism;success;Technology;Testing;tool;Training;Training Activity;Transcend;Translational Research;Translations;tribal Nation;Trust;Universities;Validation;Vietnamese;Work

PROJECT_TITLE: University of Minnesota Clinical and Translational Science Institute (UMN CTSI)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Chronic alcohol exposure leads to changes in RNA splicing process that can alter gene expression and contribute to negative affective states during alcohol withdrawal. The expression of the splicing factor PCBP1 is increased in the hippocampus of rats during withdrawal from chronic alcohol exposure and humans diagnosed with AUD. The proposed studies will focus on PCBP1 to elucidate mechanisms underlying alcohol-induced changes in RNA splicing and its relevance for negative affective states during withdrawal.

PI_NAMEs: CARVALHO, LUANA MARTINS  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Affect;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Alternative Splicing;Antibodies;Anxiety;anxiety-like behavior;Automobile Driving;Autopsy;Award;Behavior;behavior test;Behavioral;Big Data;Binding;Binding Proteins;Bioinformatics;Brain;Brain region;career development;Cell Physiology;Chronic;chronic alcohol ingestion;Complementary DNA;Complex;Darkness;Data;Data Science;design;Development;Diagnosis;Dorsal;drinking behavior;Environment;Ethanol;Ethics;Exclusion;Exons;experience;Extracellular Matrix Proteins;Future;Gene Delivery;Gene Expression;Genes;Genetic;genetic manipulation;Goals;Grant;Heavy Drinking;High-Throughput Nucleotide Sequencing;Hippocampus;Human;Immune response;Immunoprecipitation;Individual;innovation;insight;knock-down;Knowledge;Leadership;Learning;Length;Light;loss of function;male;Mediating;Mental Depression;Messenger RNA;Molecular;Morphogenesis;mRNA Expression;Nature;negative affect;Neural Conduction;neuroadaptation;neurogenesis;neuroinflammation;Neurons;neurotransmission;next generation sequencing;novel;Oral;overexpression;Phase;preference;Procedures;Process;Production;Protein Isoforms;Proteins;Rattus;Regulation;Research;research and development;Research Personnel;Ribonucleoproteins;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Signal Transduction;Site;skills;small hairpin RNA;Spliceosomes;success;Sucrose;Techniques;Testing;theories;tool;Training;Transcript;transcriptome sequencing;Translational Research;Untranslated RNA;Variant;Viral;Viral Vector;Withdrawal;Work;Writing

PROJECT_TITLE: RNA splicing regulation during alcohol withdrawal


PI_NAMEs: AMAN, JOSHUA E (contact)

PROJECT_TERMS: Address;Affect;Basal Ganglia;Bradykinesia;Brain;Brain region;catalyst;cohort;Computer Models;Data;Dedications;Deep Brain Stimulation;Development;Electric Stimulation;Electrocorticogram;Electrophysiology (science);Elements;Frequencies;Functional disorder;Generations;Globus Pallidus;Goals;high resolution imaging;Image;Implant;improved;Incidence;insight;Knowledge;Levodopa;Link;Location;Measures;Modeling;Motor;motor control;motor disorder;Motor Manifestations;neural;neural circuit;Neurons;neuroregulation;Parkinson Disease;Pathway interactions;Patients;Prefrontal Cortex;Process;Research;Resolution;response;Role;Severities;Structure of subthalamic nucleus;Techniques;Testing;theories;Time;time use;treatment optimization;Work

PROJECT_TITLE: Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural Control


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SOMERVILLE

ORG_NAME: FLUIDITY SOFTWARE, INC.

ORG_STATE: MA

PHR: Project Narrative The research conducted in this project will help to develop effective technologies for learning math and will provide a foundation for improving the STEM learning process ultimately benefiting not only those who have an aptitude for math but also for those who struggle to understand its basic principles.

PI_NAMEs: CARNEY, DONALD P (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Algebra;Aptitude;Award;Cognitive;Collaborations;Commercial grade;commercialization;Competence;Computer software;Country;Data;design;Development;Devices;Distance Learning;E-learning;Education;educational atmosphere;Educational process of instructing;Employee;Environment;Evaluation;fluidity;Foundations;Funding;Goals;graphical user interface;Hand;handheld mobile device;high school;improved;Institution;International;Investments;Learning;Legal patent;mathematical learning;Mathematics;Monitor;novel;Participant;peer;Performance;Phase;phase 2 testing;Play;Problem Solving;Process;programs;Reading;recruit;Reporting;Research;research and development;research study;Role;Science;skills;Small Business Innovation Research Grant;Students;Surveys;Tablet Computer;Tablets;teacher;Teacher Professional Development;Technology;timeline;touchscreen;United States;virtual;virtual classroom;Work;Workplace;Writing

PROJECT_TITLE: MTG: Math Team Games