NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE This proposal seeks to determine how bacteria sense and respond to changes in copper levels during urinary tract infection (UTI) and intestinal colonization. Copper levels increase in the urinary tract during infection as a protective mechanism against bacterial pathogens, yet the primary cause of UTIs, the bacteria called Escherichia coli have mechanisms to overcome copper stress and persist in the host. Our work will illuminate the pathways used by Escherichia coli to tolerate copper, opening new avenues for targeting bacterial copper detoxification mechanisms as a novel antimicrobial strategy.

PI_NAMEs: REASONER, SETH A (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;acute infection;Address;Adult;Aerobic;Affect;Anatomy;anti-microbial drug;Antibiotics;antimicrobial;Antimicrobial Resistance;Attenuated;Bacteria;Bacterial Infections;Biochemical;Bladder;career;Chronic;Copper;Data;Defect;Development;Drug Metabolic Detoxication;efflux pump;Escherichia coli;Excretory function;experience;fitness;Future;Genes;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Growth;gut colonization;Homeostasis;host colonization;Human;Immune response;Immunofluorescence Immunologic;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Infection;Infective cystitis;insight;Intestines;Knowledge;Laboratories;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Metals;Methods;Microscopy;Modeling;mouse model;Mus;mutant;novel;novel therapeutics;oxidation;Oxygen;pathogen;pathogenic bacteria;Pathway interactions;periplasm;prevent;Prevention;Prevention approach;protein-histidine kinase;Proteins;Recurrence;recurrent infection;Regulation;Research Personnel;respiratory;response;Role;Sampling;Shapes;Signal Transduction;skills;Source;spatiotemporal;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stress;System;Technical Expertise;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissue Sample;Toxic effect;toxic metal;transcription factor;Tropism;Urinary tract;Urinary tract infection;Urine;Uropathogen;Uropathogenic E. coli;Vagina;Virulence;Work

PROJECT_TITLE: Copper Sensing in Uropathogenic Escherichia coli


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Nutrition;Prevention;Vaccine Related

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Streptococcus pyogenes is a strict human pathogen that causes an estimated ~ 600 million cases of strep throat and 500,000 cases of invasive disease-related deaths worldwide. The proposed research is significant and relevant to the NIH mission because it is expected to elucidate the molecular details of GAS-host interactions and identify novel vaccine targets for disease prevention.

PI_NAMEs: KUMARASWAMI, MUTHIAH  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Abscess;Active Immunization;Affinity;Anatomy;Antibodies;Antigenic Variation;Antigens;Autoimmune;Binding;cell capsule;Cell membrane;Cell Wall;Cells;Cessation of life;Child;Coated vesicle;cross reactivity;Data;Development;Disease;disorder prevention;Engineering;Environment;extracellular;Face;Genetic Variation;Gram-Positive Bacteria;Growth;Healthcare;Heart Diseases;Human;human pathogen;human tissue;Immune;Immune response;Immunization;immunogenic;immunogenicity;Infection;Integration Host Factors;interdisciplinary approach;Leukocyte L1 Antigen Complex;Licensing;Masks;Mediating;Membrane;metal chelator;Metals;microbial;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Natural Immunity;neutrophil;nonhuman primate;novel;novel vaccines;nutrient deprivation;Nutritional;Oropharyngeal;pathogen;Pathogenesis;Peptidoglycan;Persons;Pharyngeal structure;Pharyngitis;prevent;prophylactic;protective efficacy;Proteins;Public Health;recruit;Research;Resistance;Rheumatic Heart Disease;Role;Safety;Serotyping;side effect;Site;Starvation;Streptococcal Infections;Streptococcal Vaccines;Streptococcus;Streptococcus pyogenes;Stress;Surface;System;Testing;Thick;Translational Research;United States National Institutes of Health;uptake;Vaccination;vaccination strategy;vaccine candidate;vaccine development;Vaccines;Vesicle;Virulence;Work;Zinc

PROJECT_TITLE: Molecular mechanism of streptococcal adaptation to host nutritional defenses

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Opioid abuse disorders are growing in prevalence, making models that can help predict individuals who are susceptible to substance abuse more critical than ever. Here we propose to model this heterogeneity by integrating rich behavioral data on emotionality, pain sensitivity, and motivated behaviors with neuroanatomical findings using advanced statistical approaches. Ultimately, these data can provide a highly translatable model of opioid abuse that reflects the heterogeneity of the disease.

PI_NAMEs: O'BRIEN, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;Acute Pain;addiction;Affective;Agonist;Anatomy;Anhedonia;Anxiety;Area;Automobile Driving;Behavior;behavior influence;behavior test;Behavioral;Behavioral Model;behavioral phenotyping;behavioral response;Brain;career;chronic pain;Collaborations;Communities;comorbidity;Complex;complex data;Consummatory Behavior;Coupled;Data;Data Set;designer receptors exclusively activated by designer drugs;Development;dimension reduction;Disease;disease heterogeneity;Dose;Emotional;Environment;Equilibrium;Experimental Designs;Faculty;Fellowship;Female;Fentanyl;foot;Foundations;Genetic;genetic manipulation;Glutamates;Goals;Grant;Habenula;Heterogeneity;Hyperactivity;Hypersensitivity;In Situ Hybridization;Individual;Individual Differences;Injections;interest;kappa opioid receptors;Lateral;Literature;male;Measures;Mechanics;Mediating;member;Mental Depression;Mental disorders;Mentorship;Methodology;Modeling;Molecular;molecular phenotype;motivated behavior;mRNA Expression;mu opioid receptors;Mus;Negative Valence;Neuroanatomy;neuromechanism;Neurons;Neurosciences;new therapeutic target;Nociception;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;Opioid Receptor;opioid use;opioid use disorder;Output;Pain;pain sensitivity;Pathway interactions;Phenotype;Population;Predisposition;preference;Prevalence;Prevention;Process;Psyche structure;Quantitative Reverse Transcriptase PCR;receptor expression;Recording of previous events;response;reward processing;Rewards;Risk;Risk Factors;Rodent;Role;sex;Shock;skills;statistics;Stress;Stressful Event;Structure;Students;Substance abuse problem;Substance Use Disorder;Sucrose;Techniques;Testing;Training;transcriptomics;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Molecular and Neuroanatomical Processes of Opioid addiction


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Primary aldosteronism (PA), although once considered a rare disease, is estimated to affect 5-10% of patients with hypertension. This illness is characterized by uncontrolled aldosterone production by cytochrome P450 11B2 (CYP11B2). Given the lack of current treatments and the high incidence of cardiovascular (heart failure, stroke, tachycardia…) events in patients with PA, it is pivotal to understand the reactions catalyzed by CYP11B2 to assist aid drug development.

PI_NAMEs: VALENTIN-GOYCO, JUAN JOSE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Adrenodoxin;Adverse effects;Affect;Aldosterone;Amino Acids;Analytical Chemistry;antagonist;Aryl Hydrocarbon Hydroxylases;Binding;Biological Assay;blood pressure control;blood pressure regulation;Cardiovascular system;Cells;Cellular Assay;Cessation of life;Cholesterol;Clinical Research;Complex;Corticosterone;Cortodoxone;Coupled;crosslink;CYP11B2 gene;Cytochrome P450;Deoxycorticosterone;Devices;Disease;Dissociation;Drug Design;drug development;Embryo;Enhancers;Enzyme Kinetics;Enzymes;Event;experimental study;Ferredoxin-NADP Reductase;Functional disorder;heart cell;Heart failure;high risk;Homeostasis;Hormones;Hydrocortisone;Hydroxylation;Hyperaldosteronism;Hypertension;Impairment;In Vitro;Incidence;inhibitor;Inner mitochondrial membrane;Isoenzymes;Kidney Failure;Kinetics;Knowledge;Length;Mass Spectrum Analysis;Mineralocorticoid Receptor;Mineralocorticoids;Mitochondria;Monitor;Mutation;Myocardial Infarction;nanodisk;Operative Surgical Procedures;Oxidases;oxidation;Oxidation-Reduction;Patients;Phospholipids;Physiologic pulse;Plague;Point Mutation;Production;Property;protein expression;Publishing;Rare Diseases;Rattus;Reaction;reconstitution;Renin-Angiotensin System;Research;Role;Secondary Hypertension;side effect;Sodium;Spironolactone;standard of care;Steroid biosynthesis;steroidogenic acute regulatory protein;Stroke;Structure;Tachycardia;Testing;Therapeutic;therapy design;Water

PROJECT_TITLE: Processivity and Catalytic Mechanism of Aldosterone Synthase


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed project will provide novel large-scale data on emerging workplace practices in the service sector related to surveillance and sanctioning, schedule unpredictability and constraint, and automation, and assess their implications for worker’s health and healthy aging. Our study will reveal how temporal dimensions of job quality differentially affect health across the life course and how social supports at the individual and macro levels may buffer any negative effects on health. The proposed data collection will take advantage of natural experiments at the local and company level that induce exogenous changes in job quality and thus build the evidence-base on the effects of emerging workplace practices on population health.

PI_NAMEs: HARKNETT, KRISTEN ;SCHNEIDER, DANNY  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Advertisements;Advertising;Affect;Age;American;Area;Automation;Buffers;caregiving;Cities;Conflict (Psychology);cost;Country;Data;Data Collection;Data Set;Data Sources;deprivation;design;Dimensions;Economic Conditions;Economics;Employee;evidence base;expectation;Exposure to;Facebook;Family;fast food;Fringe Benefit;Future;Health;Health behavior;healthy aging;human old age (65+);Individual;innovation;insight;Instagram;Knowledge;large scale data;Laws;Life;Life Cycle Stages;Link;Longitudinal Surveys;Measures;Mediation;Mental Health;Methods;Modeling;Natural experiment;new technology;novel;novel strategies;Occupations;Outcome;Personal Satisfaction;physical conditioning;Policies;Policy Maker;Policy Making;Population;population health;recruit;Research;Research Personnel;Role;safety net;Sampling;Schedule;Services;Shapes;Signal Transduction;social;social relationships;Social support;Social Work;Speed;Surveys;Target Populations;Testing;Time;Uncertainty;Variant;Wages;Woman;Work;Workplace

PROJECT_TITLE: Effects of Job Quality in the Service Sector on Health-Related Outcomes Across the Life Course

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: We propose a new paradigm to understand how cells assemble cytoplasmic anchoring and signaling complexes at sites in the body to which they adhere. Our newly developed methods will enable us to obtain a complete accounting of the contents of the modular building blocks of these adhesions and to use that information to understand how these adhesions can control processes such as the passage of white blood cells through the body, the clumping of platelets that leads to heart attack and stroke, and the health and behavior of the endothelial cells that line our blood vessels.

PI_NAMEs: GINSBERG, MARK HOWARD (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Accounting;Adhesions;Behavior;Binding Sites;Biochemical;Blood;Blood Platelets;Blood Vessels;Cell Adhesion;cell assembly;Cell Line;cell motility;Cells;Complex;Cytoplasm;Data;density;dynamical evolution;Endothelial Cells;experimental study;Family;Future;Health;Heterogeneity;Image;Integrins;Leukocytes;Ligation;member;Mesenchymal;Methods;Molecular;Myocardial Infarction;novel strategies;Output;physical state;Process;Proteins;Regulation;Resources;Rod;Signal Transduction;Site;Stroke;Structure;Talin;Testing;therapeutic target;Vinculin;Visualization

PROJECT_TITLE: Deconvoluting the Vascular Adhesome


ADMINISTERING_IC: AR

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Nanotechnology;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Duchenne Muscular Dystrophy (DMD) is a heritable and lethal muscle wasting disease with no cure at the present time. This project aims to investigate the pathological function of the PTEN protein in dystrophic muscles, and to explore the potential of treating DMD in an animal model through inhibiting PTEN using a novel nanoparticle targeted delivery system. Knowledge from the proposed work will lead to better understanding of pathogenesis of DMD and establish a new therapeutic strategy to treat DMD.

PI_NAMEs: KUANG, SHIHUAN  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Adult;Animal Model;Area;Cells;clinical development;clinical translation;Clinical Trials;Data;Degenerative Disorder;Development;Disease;Disease Progression;Drug Delivery Systems;Duchenne muscular dystrophy;Dystrophin;evidence base;experience;FBXO32 gene;Foundations;FRAP1 gene;Future;GDF8 gene;gene therapy;Generations;Genes;Growth;Growth Factor;Health;Heritability;Homologous Protein;Human;improved;in vivo;inhibitor;insight;Knock-out;knockout gene;Knockout Mice;Knowledge;Link;mdx mouse;Mediating;Membrane;Membrane Proteins;Modeling;Molecular;Motility;mouse model;Mus;Muscle;Muscle Cells;muscle degeneration;Muscle Development;Muscle function;muscle hypertrophy;muscle progenitor cell;Muscle Proteins;Muscle satellite cell;Muscular Atrophy;Muscular Dystrophies;Mutation;myogenesis;nanoparticle;nanoparticle delivery;nanoparticle drug;nanopolymer;Natural regeneration;new therapeutic target;notch protein;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;PAX7 gene;Pharmaceutical Preparations;pharmacologic;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphorylation Inhibition;PI3K/AKT;PIK3CG gene;pre-clinical;preclinical study;Protein Biosynthesis;protein degradation;Protein Dephosphorylation;Proteins;Proto-Oncogene Proteins c-akt;prototype;PTEN gene;Publishing;repaired;Research;Respiration;Respiratory Failure;Risk;Role;Safety;side effect;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Solid;Specificity;stem cell therapy;stem cells;System;targeted delivery;targeted treatment;Testing;Therapeutic;Time;Tissues;Transcription Coactivator;translatable strategy;Translating;Treatment Efficacy;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation;wasting;Wasting Syndrome;Work

PROJECT_TITLE: Targeting PTEN to ameliorate muscular dystrophy in a mouse model


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Identification of novel pathogenic factors that modulate fatty liver disease severity is of both basic science and clinical significance. This study aims to understand how altered sulfur amino acid metabolism contributes to liver fat accumulation and inflammation in fatty liver disease. In addition, this study investigates the mechanisms regulating hepatic sulfur amino acid metabolism and if they serve as potential therapeutic targets for treating fatty liver disease.

PI_NAMEs: LI, TIANGANG  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Alcoholic Liver Cirrhosis;amino acid metabolism;Animal Model;Attenuated;Automobile Driving;Basic Science;Bile Acids;Cholestasis;clinically significant;Coenzyme A;Complex;Cysteine;Cysteine dioxygenase;Defect;Diet;Enzymes;Essential Amino Acids;Etiology;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;fatty liver disease;Fibroblast Growth Factor;flexibility;Future;gain of function;Genetic;Glutathione;Goals;Hepatic;Hepatocyte;Homeostasis;Human;human model;Impairment;improved;Inflammation;Injury;insight;Knockout Mice;Knowledge;Link;lipid metabolism;Liver;Liver diseases;loss of function;Malignant neoplasm of liver;Mediating;Metabolic;Metabolism;Methionine;methionine adenosyltransferase;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Target;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nutrient;Organ;Output;Oxidative Stress;Pathogenicity;Physiological;Physiology;Predisposition;preservation;Regulation;Reporting;Role;Severities;Severity of illness;Signal Transduction;Stress;Sulfur;Sulfur Amino Acids;Taurine;Testing;Therapeutic Intervention;therapeutic target;transcription factor;Transgenic Mice;Up-Regulation;Virulence Factors

PROJECT_TITLE: Sulfur Amino Acid Metabolism and Regulation of Hepatic Metabolic Flexibility

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Infectious Diseases;Kidney Disease;Sepsis

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT Narrative: The dosing of drugs with a narrow therapeutic index in hemodynamically unstable patients, such as those on continuous renal replacement therapy (CRRT), is exceptionally challenging and necessitates a personalized approach tailored in real-time to each patient’s changing conditions. Building on our recent demonstrations of closed-loop feedback control over plasma drug levels in a living animal, we propose the development and validation of a first-in-class approach to performing real-time therapeutic drug monitoring of extracorporeal clearance in sepsis patients undergoing CRRT. This will enable the rapid, personalized adjustment of antibiotic dosing in grievously ill patients for whom the margin for therapeutic error is smallest.

PI_NAMEs: MOHAN, SUMIT  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adsorption;Amikacin;Aminoglycosides;Animals;Antibiotics;antimicrobial;appropriate dose;aptamer;awake;Binding;Binding Proteins;Biological Assay;Blood;Cessation of life;Clinical;clinical application;clinical trial readiness;Clinical Trials;Consensus;Critical Illness;Data;Death Rate;design;Development;Dialysis procedure;dosage;Dose;drug clearance;Drug Exposure;Drug Kinetics;Drug Monitoring;Ensure;Excision;experimental study;Feedback;Filtration;Frequencies;hemodynamics;Hospitals;Hour;improved outcome;In Vitro;in vitro Model;Incidence;Individual;individualized medicine;Infection;Inferior;Institutional Review Boards;Intensive Care Units;Kidney;Laboratories;Lead;Libraries;Life;Liquid substance;Measurement;Measures;Membrane;Metabolic Clearance Rate;Modality;Modeling;Monitor;Oligonucleotides;Outcome;Patient Monitoring;Patients;personalized approach;Pharmaceutical Preparations;Physiological;Physiology;Plasma;programs;Protocols documentation;rapid test;Rattus;receptor;Renal function;Renal Replacement Therapy;Research;Sampling;sensor;Sepsis;septic;septic patients;Serum;Side;small molecule;Technology;Therapeutic;Therapeutic Index;Time;Tobramycin;tool;Toxic effect;Translating;Validation;validation studies;Vancomycin;Variant;wasting;Whole Blood;Work

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Tuberculosis (TB) and HIV infection remain major global health challenges for which improved treatment options for cure are actively sought. Our recent research has revealed that immune suppressor cells in humans and animals act to prevent pathogen destruction, and we have developed novel drug-like agents to target and kill these suppressor cells. In this study, we will characterize the effects of suppressor cell depletion on the containment of TB and the reactivation of latent HIV—studies that could lead to improved therapies for both diseases.

PI_NAMEs: BISHAI, WILLIAM RAMSES (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acute;Address;Animals;Bacille Calmette-Guerin vaccination;Biological Products;cancer therapy;CD4 Positive T Lymphocytes;Cells;Chimeric Proteins;Chronic;Containment;Data;Denileukin Diftitox;Diphtheria Toxin;Disease;efficacy evaluation;FOXP3 gene;global health;Granuloma;HIV;HIV Infections;HIV/TB;Human;IL2 gene;IL2RA gene;IL4 gene;IL4R gene;Immunosuppressive Agents;Immunotherapy;improved;Indoles;ITGAM gene;Lung;Maintenance;Methods;Modeling;Mus;Mycobacterium tuberculosis;Myeloid-derived suppressor cells;Necrosis;novel;novel therapeutics;Oryctolagus cuniculus;pathogen;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacotherapy;Play;prevent;Process;Proliferating;reactivation from latency;Research;Role;single-cell RNA sequencing;Spleen;Suppressor-Effector T-Lymphocytes;System;Technology;translational applications;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis immunity;Vaccine Adjuvant;Virus Replication

PROJECT_TITLE: Targeted cell-depleting immunotherapy for TB and HIV

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This proposal investigates the mechanism by which human sinonasal epithelial cell production of the central complement component C3 drives inflammation associated with chronic rhinosinusitis. The overall goal is to utilize this information to design novel therapeutic strategies to treat sinusitis.

PI_NAMEs: ATKINSON, CARL ;MULLIGAN, JENNIFER KONOPA (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: adaptive immune response;airway epithelium;Allergic;Anatomy;autocrine;Carrier Proteins;Cell Culture System;Cell Line;Cell Physiology;cell type;Cells;Chronic;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Clinical Research;Clinical Trials;clinically relevant;Complement;Complement 3a;Complement Activation;complement C3 precursor;Complement Inactivators;complement pathway;complement system;conditional knockout;design;Development;Disease;early phase clinical trial;Epithelial Cells;Epithelium;extracellular;Functional disorder;Generations;Goals;Heart failure;Human;immune cell infiltrate;Immune System Diseases;In Vitro;inducible Cre;Inflammation;Inflammatory;Innate Immune Response;innovation;insight;Intercellular Fluid;Irritants;irritation;knockout animal;Laboratories;Location;Lymph;Mediating;Modeling;mouse Cre recombinase;mouse model;Mucositis;Mucous Membrane;Mus;Nasal Polyps;Nature;Nose;novel;novel strategies;novel therapeutic intervention;Outcome;Pathogenesis;Patients;Penetration;Play;pre-clinical;Production;Proteins;Quality of life;receptor;Recording of previous events;Regulation;Reporter;Reporting;Role;Serum;Severity of illness;Shapes;Signal Transduction;Sinus;Sinusitis;Source;Stimulus;success;Systemic Therapy;T-Lymphocyte;Tamoxifen;Testing;Therapeutic;Therapeutic Agents;Therapy Clinical Trials;Tissues;Tomatoes;tool;Topical application;translational study;tumor-immune system interactions

PROJECT_TITLE: Epithelial cell complement production in the pathogenesis of chronic rhinosinusitis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Pain Research;Prevention;Rheumatoid Arthritis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A critical need exists for non-pharmacologic interventions that improve outcomes in patients with chronic autoimmune conditions such as rheumatoid arthritis (RA). This study will leverage infrastructure and resources from an RO1-funded cohort to longitudinally examine the effects of psychological stress, stress resilience, and mindfulness on RA disease activity and symptom severity. These findings will provide mechanistic targets for mindfulness-based interventions in RA, and inform a pilot randomized controlled trial of mindfulness-based stress reduction (MBSR) for improving outcomes among people with chronic autoimmune conditions.

PI_NAMEs: PATTERSON, SARAH LYNN (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adverse event;Affect;American;Arthralgia;Autoimmune Diseases;Biological;Blood specimen;Cardiovascular Diseases;career development;Chronic;Chronic Disease;chronic pain;Clinical;Clinical assessments;Clinical Trials;cohort;Communities;Data;design;Disease;Disease Outcome;Disease-Modifying Second-Line Drugs;disorder risk;Enrollment;Equation;evidence base;experience;Fatigue;Feedback;Flare;Focus Groups;follow-up;Foundations;Frequencies;Funding;Future;Goals;Immune;improved;improved outcome;Inflammatory;Inflammatory Arthritis;Infrastructure;innovation;instrument;Intervention;intervention effect;intervention program;joint inflammation;K-Series Research Career Programs;Knowledge;Life;Longitudinal cohort study;Longitudinal Studies;Measures;Mediating;Medical;Medicine;Methods;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness-based stress reduction;Modeling;Nonpharmacologic Therapy;Outcome;Pain;Participant;Patient Outcomes Assessments;patient population;Patients;perceived stress;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Pilot Projects;pilot test;premature;Premature Mortality;Preparation;programs;prospective;Psychological Impact;Psychological Stress;Psychosocial Stress;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;resilience;resilience factor;resilience scale;Resources;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Sampling;Scientist;Severities;Severity of illness;side effect;Sleep disturbances;Standardization;Stress;stress management;stress reduction;stress resilience;Symptom Burden;Symptoms;systemic autoimmune disease;systemic inflammatory response;Testing;Therapeutic;Time;Training;treatment as usual;treatment strategy;United States

PROJECT_TITLE: Defining stress REsilience And Mindfulness Effects in Rheumatoid Arthritis (DREAMER)


ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Relevance to Public Health: TGF- ligands represents a diverse array of signaling molecules that have fundamental roles human biology and disease. In this proposal, we will characterize the molecular mechanisms of how ligands signal and how they are regulated. This information will provide mechanistic insight into the structure-function of TGF- ligands, augmenting efforts for therapeutic intervention.

PI_NAMEs: THOMPSON, THOMAS B (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Activins;antagonist;Apolipoproteins;Binding;Biogenesis;Biological Process;Cellular Assay;Collection;Complex;Coupled;dimer;Disparate;disulfide bond;Event;extracellular;Extracellular Protein;Growth Factor;Human Biology;human disease;In Vitro;insight;Laboratories;Ligands;Lipid Binding;Lipids;Lipoproteins;Mediating;Molecular;N-terminal;particle;protein phosphatase inhibitor-2;Public Health;receptor;Regulation;Research;Role;Shapes;Signal Transduction;Signaling Molecule;Structure;Therapeutic Intervention;Transforming Growth Factor beta;X-Ray Crystallography

PROJECT_TITLE: Structural/functional characterization of TGFβ superfamily signaling and regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Vaccine Related

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE In sub-Saharan Africa, nontyphoidal Salmonella (NTS) serovars Enteritidis and Typhimurium are major causes of invasive bacterial disease in children, and we have developed two promising NTS glycoconjugate vaccine candidates. In this application, I will apply systems vaccinology to uncover predictive molecular signatures of NTS glycoconjugate vaccine responsiveness, and additionally, I will define mechanistic humoral correlates of protection using infant mice (mimicking the target population for NTS vaccines). These findings will inform the development of serological assays to evaluate candidate NTS vaccines in clinical testing, which has implications for the design of upcoming efficacy trials in human infants.

PI_NAMEs: BALIBAN, SCOTT M. (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Adult;Africa South of the Sahara;Animal Model;Antibiotics;Antibodies;Antibody Response;Antibody-mediated protection;antimicrobial;Area;Award;Bacterial Infections;Bacterial Model;Bioinformatics;Biological Markers;career;career development;Chemicals;Child;Childhood;clinical development;cohort;Communicable Diseases;Complement;complex data;Computational Biology;Computer Analysis;Computer Models;Conjugate Vaccines;Data;data integration;Data Set;design;Development;Disease;Doctor of Philosophy;Early identification;efficacy trial;Elements;Ensure;Flagellin;Future;Gene Expression;Genetic Transcription;Glycoconjugates;Goals;Gram-Negative Bacteria;Human;Human Volunteers;Immune response;Immune Sera;Immunity;Immunization;immunogenic;Immunology;in vivo;infancy;Infant;Infection;insight;Investigation;Knowledge;Link;Machine Learning;machine learning algorithm;Macrophage;Measures;Mentored Research Scientist Development Award;Mentors;Metabolic;metabolomics;Modeling;Molecular;Molecular Profiling;monomer;Morbidity - disease rate;mortality;mouse model;Multiomic Data;Mus;Nature;non-typhoidal Salmonella;novel;O Antigens;Pathogenicity;Pathway interactions;Phenotype;Polysaccharides;Positioning Attribute;predictive modeling;predictive signature;Process;Program Development;Proteins;Public Health;rational design;Research;research clinical testing;Research Personnel;Resistance;response;Salmonella infections;Salmonella typhimurium;Salmonella Vaccines;seroconversion;Serology;Serology test;Serum;skills;success;Surface;System;Systemic infection;Target Populations;Training;transcriptomics;Vaccinated;Vaccination;vaccination outcome;vaccine candidate;vaccine development;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;vaccinology;Virulent

PROJECT_TITLE: Systems Vaccinology Approaches to Define and Predict Immunity in Response to Nontyphoidal Salmonella Conjugate Vaccines

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: Despite ongoing efforts to improve outcomes in heart failure (HF), a leading cause of mortality and elevated healthcare costs, 30-day HF readmission rates remain elevated and a quarter of these are preventable. Community health worker (CHW) care delivery has been shown to improve healthcare outcomes but inefficiency limits its scalability. Implementation of a 30-day digitally-enabled CHW intervention for HF patients may provide support for similar interventions in larger HF/cardiovascular populations by reducing 30-day readmissions and improving patient engagement.

PI_NAMEs: CARTER, JOCELYN ALEXANDRIA (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Affect;Area;Artificial Intelligence;Attention;Automobile Driving;barrier to care;Behavioral;behavioral and social science;Behavioral Sciences;Biometry;Biotechnology;Cardiovascular Diseases;Cardiovascular system;care delivery;care outcomes;career;Caring;Cellular Phone;Chronic Disease;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Communication;Community Health Aides;Community Healthcare;comorbidity;comparison intervention;Complex;cost;Data;design;Development;Diet;digital;digital data;digital platform;Disease;Disease Outcome;Early identification;Economics;Education;effective intervention;Effectiveness;Evaluation;experience;Fostering;General Practitioners;Goals;Health;Health Care Costs;health difference;Health Personnel;Heart failure;Heart Research;hospital readmission;Hospitalization;Hospitals;implementation research;improved;improved outcome;innovation;Inpatients;interdisciplinary approach;Intervention;Interview;Investigation;Knowledge;Literature;Medical;Medical Care Costs;Medicine;meetings;member;Mentorship;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel therapeutic intervention;Outcome;Patient Care;patient engagement;Patients;Persons;pilot trial;Pneumonia;Population;prevent;prototype;provider communication;Qualitative Methods;Qualitative Research;Randomized, Controlled Trials;readmission rates;Research;Research Personnel;Services;Singapore;skills;social;social factors;Social support;Socioeconomic Status;Strategic vision;Structure;Technology;technology intervention;Telemetry;Testing;therapy design;therapy development;Training;treatment as usual;United States;usability;Work

PROJECT_TITLE: Implementing a digitally-enabled community health worker intervention for patients with heart failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE  Community pharmacy is an underutilized location for identifying and engaging those who misuse opioid medications. Our highly experienced, interdisciplinary research team proposes the current powered randomized controlled trial across 14 community pharmacies to test the efficacy of the Brief Intervention-Medication Therapy Management intervention (BI-MTM). The establishment of the BI-MTM model will result in a major impact for addressing the opioid epidemic, preventing opioid use disorder and overdose, and safeguarding patient health in a novel community-based service setting.

PI_NAMEs: COCHRAN, GERALD T. (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: addiction;Address;Adverse event;American;Behavior;brief intervention;brief motivational intervention;causal model;Clinical;Collaborations;Communities;community based service;Community Pharmacy;Complex;Counseling;Data;drug misuse;Drug Monitoring;Drug Prescriptions;effectiveness trial;efficacy testing;efficacy trial;Eligibility Determination;Evaluation;Exhibits;experience;Feasibility Studies;Future;group intervention;Health;improved;Individual;instrument;integrated care;Interdisciplinary Study;Intervention;Knowledge;Link;Location;Measures;Medication Management;Mental Depression;Methods;Modeling;Monitor;multi-component intervention;multi-site trial;Naloxone;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Overdose;Pain;Participant;Pathway interactions;Patient Care;patient engagement;patient navigation;patient screening;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Pilot Projects;Population;post intervention;prescription opioid;prescription opioid misuse;prevent;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;response;Risk;satisfaction;screening;Service setting;Services;Signal Transduction;Single-Blind Study;Site;sociodemographics;Subgroup;Telephone;Time;tool;Toxicology;Training;Treatment Efficacy;treatment group;trend;US State;Utah

PROJECT_TITLE: Prescription Opioid Misuse: A Pharmacist-Led Intervention at Point of Service Efficacy Trial

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;Genetics;Prevention;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The current grant proposal uses novel genetically engineered mouse models to investigate how genetic changes in the digestive enzyme chymotrypsin increase susceptibility for pancreatitis, a progressive inflammatory disease of the pancreas. The underlying hypothesis is that chymotrypsin deficiency results in pancreatitis in the context of additional genetic or environmental risk factors. Results from this study can advance the development of novel therapeutic and preventive interventions for acute and chronic pancreatitis in humans.

PI_NAMEs: SAHIN-TOTH, MIKLOS  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: acute pancreatitis;Advanced Development;Age of Onset;alcohol exposure;Alcoholic Pancreatitis;Alcohols;Alleles;Applications Grants;C57BL/6 Mouse;C57BL/6N Mouse;chronic pancreatitis;chymotrypsin;chymotrypsin C;chymotrypsin inhibitor;Chymotrypsinogen;Development;Diet;Disease;Environmental Risk Factor;Enzymes;Exhibits;experimental study;Funding;Gene Dosage;Genes;Genetic Diseases;genetic manipulation;Genetic Models;Genetic Risk;genetic variant;Genetically Engineered Mouse;Genotype;Grant;hereditary pancreatitis;Heterozygote;High Prevalence;Hormonal;Human;Inflammatory;inhibitor;Liquid substance;loss of function;loss of function mutation;Loss of Heterozygosity;mesotrypsin;Modeling;mouse model;Mouse Strains;Mus;Mutation;Names;novel;novel therapeutic intervention;Onset of illness;Orthologous Gene;Other Genetics;Pancreas;Pancreatic Diseases;Pancreatitis;Patients;Play;Predisposition;preventive intervention;Property;Protein Isoforms;response;restoration;Risk;Risk Factors;risk variant;Role;Severities;Severity of illness;SPINK1 gene;synergism;Trypsin;Trypsin Inhibitors;Trypsinogen;Up-Regulation;Variant

PROJECT_TITLE: Chymotrypsin in pancreatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative. cGMP phosphodiesterases (PDE6 family) that are expressed in the rod and cone photoreceptor cells are the key effector enzymes in vision and depend on a specialized chaperone, aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), and the ubiquitous heat shock protein 90 (HSP90) for their maturation and activity. Mutations in PDE6 and AIPL1 underlie severe retinal diseases in humans, including retinitis pigmentosa, achromatopsia and Leber congenital amaurosis. We aim to elucidate the mechanisms underlying AIPL1/HSP90-assisted maturation of PDE6 to enable development of new therapeutic approaches for treating the visual disorders linked to PDE6 and AIPL1.

PI_NAMEs: ARTEMYEV, NIKOLAI O (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: achromatopsia;Animal Model;ARA9 protein;autosome;Binding Sites;Biochemical;Blindness;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;Child;Complex;Cone;Cyclic GMP;Cyclic Nucleotides;Data;Defect;design;Development;dimer;effective therapy;Ensure;Enzymes;Family;FK506 binding protein 5;Functional disorder;Genes;Goals;Health;Heat-Shock Proteins 90;Human;human model;in vivo;insight;Knock-out;Knockout Mice;Knowledge;Leber's amaurosis;Link;Mediating;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;mouse model;Mus;Mutation;Mutation Analysis;Night Blindness;novel therapeutic intervention;Outcome;Pathogenicity;Patients;Phenotype;phosphoric diester hydrolase;photoreceptor degeneration;Photoreceptors;Phototransduction;Play;programs;protein folding;Protein Isoforms;Proteins;Regulation;Research;Retina;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Rod;Role;Structure;System;Testing;Therapeutic;treatment strategy;Vertebrate Photoreceptors;Vision;Vision Disorders;Visual System

PROJECT_TITLE: Regulation of Retinal cGMP-Phosphodiesterases

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE (RELEVANCE) The design of new drugs to treat major mental disorders remains challenging and error-prone. This grant seeks to discover how drugs used for treating mental disorders bind to an modulate the activity of their receptor sites of action. Such information could be used to accelerate the discovery of new treatments for serious mental disorders such as schizophrenia and depression.

PI_NAMEs: ROTH, BRYAN L. (contact);SHOICHET, BRIAN K

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acceleration;Agonist;antagonist;Anxiety;Arrestins;atypical antipsychotic;autism spectrum disorder;Binding;Characteristics;Chemicals;Complex;Coupling;Cryoelectron Microscopy;design;Development;Disease;Docking;drug action;Drug Interactions;Drug Targeting;Drug usage;drug-like compound;Eating Disorders;Enzymes;Essential Drugs;Family;G-Protein-Coupled Receptors;Generations;Grant;GTP-Binding Proteins;HTR2A gene;Hydrophobicity;improved;innovation;insight;Investigation;Ion Channel;Libraries;Ligands;Membrane Proteins;Mental Depression;Mental disorders;Modeling;Molecular;Molecular Conformation;molecular modeling;Mutagenesis;neuropsychiatric disorder;new technology;novel;novel therapeutics;Obesity;Pattern;Pharmaceutical Preparations;Phosphorylation;programs;Property;Protein Isoforms;Psychoses;Psychotropic Drugs;receptor;receptor binding;Research;Resolution;RNA Editing;Schizophrenia;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2C;severe mental illness;Signal Transduction;Site;Site-Directed Mutagenesis;Sleep Disorders;small molecule libraries;Structure;Tail;Testing;tool;Transducers

PROJECT_TITLE: Molecular Details of Psychoactive Drug Actions

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Immunotherapy;Lymphatic Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Patients with autoimmune diseases such as multiple sclerosis would benefit from new therapies that prevent the immune system from attacking healthy tissue, without the immune-suppressive side effects of existing treatments. We have shown biomaterial depots deposited in lymph nodes - key tissues that determine how immune responses develop, promote selective tolerance during pre-clinical models of multiple sclerosis. In this project we will determine how these selective effects are induced and maintained across key immune populations - T and B cells - to generate knowledge that contributes to design of effective and selective MS immunotherapies.

PI_NAMEs: JEWELL, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Adopted;Adoptive Transfer;Aftercare;Antibodies;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Biocompatible Materials;biodegradable polymer;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;Central Nervous System;Chronic;Clinical;combat;controlled release;Cues;cytokine;Data;Deposition;design;Diffusion;Disease;Distant;draining lymph node;efficacy testing;Engineering;Environment;Equilibrium;Experimental Autoimmune Encephalomyelitis;Face;Family;Goals;Health Care Costs;Histology;Human;Humira;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;Immunocompromised Host;immunoengineering;Immunologics;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Infiltration;Inflammation;Inflammatory;Infusion procedures;injection/infusion;Injections;Interleukin-10;Kinetics;Knockout Mice;Knowledge;Link;lymph node microenvironment;lymph nodes;Magnetic Resonance Imaging;Maintenance;Memory;migration;Modeling;Monoclonal Antibodies;Multiple Sclerosis;multiple sclerosis treatment;Mus;Myelin;nanoparticle;Nanotechnology;Nature;Nerve Degeneration;Nervous System Physiology;neuroinflammation;novel therapeutics;Paralysed;particle;Pathogenicity;Patients;Peptides;Pharmaceutical Preparations;Play;polarized cell;Polymers;Population;Pre-Clinical Model;preclinical study;Preclinical Testing;prevent;Process;Production;programs;Regulatory T-Lymphocyte;remyelination;Reporter;response;Rest;Route;side effect;Signal Transduction;Sirolimus;Site;Societies;Specificity;Structure;Structure of germinal center of lymph node;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Tissues;TNF gene;transdifferentiation;Transgenic Organisms;Vaccines;Vision;Work

PROJECT_TITLE: Defining the induction and maintenance of myelin-specific tolerance in T cells and B cells using local lymph node depots

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cannabinoid Research;Cerebrovascular;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Natural Products;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Cannabis Products (THC,CBD) are widely used by HIV+ individuals; however, interactions between HIV, ART, cannabinoids and the endoCB system are poorly understood. Furthermore, the blood-brain barrier serves as a gatekeeper in regulating the delicate neuronal environment and its dysfunction is considered a hallmark of NeuroHIV. We propose to investigate how cannabis products alter important functions of the BBB (i.e. transport, immunological and physical barriers) and the implications on HIV neuroinflammation.

PI_NAMEs: PERSIDSKY, YURI  (contact);RAMIREZ, SERVIO HEYBERT

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Adhesions;Affect;Agonist;Animal Model;Antiinflammatory Effect;antiretroviral therapy;Aseptic Meningitis;ATP-Binding Cassette Transporters;Attenuated;beta catenin;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain endothelial cell;brain tissue;cannabinoid administration;cannabinoid receptor;Cannabinoids;Cannabis;CD44 gene;Cells;Cellular biology;Cerebral endothelium;cerebrovascular;Chronic;chronic pain;Clinical Research;CNR1 gene;CNR2 gene;Communities;Complex;cytokine;Drug Kinetics;Dwarfism;Encephalitis;Endocannabinoids;endogenous cannabinoid system;Endothelium;Environment;Enzymes;Evaluation;experience;experimental study;Functional disorder;Gatekeeping;Genes;HIV;HIV Infections;Human;humanized mouse;Immune;Immunologic Surveillance;Immunologics;immunoregulation;Impaired cognition;in vivo;increased appetite;indexing;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Inhalation Drug Administration;innovation;Kinetics;Macrophage;Maintenance;marijuana use;Mediating;Medical Marijuana;member;Microfluidic Microchips;microfluidic technology;Microfluidics;Microglia;migration;Modeling;Modernization;Molecular;Molecular Analysis;Molecular Weight;monocyte;mouse model;Nervous System Disorder;neural network;neuroAIDS;Neurocognitive;neuroinflammation;Neurons;neurovascular unit;novel;operation;Oral;Oral Administration;Outcome;Output;Pathology;Pathway interactions;Permeability;Persons;Pharmacodynamics;Physical assessment;Physiological;phytocannabinoid;PPAR gamma;pre-clinical;Pre-Clinical Model;Property;protein expression;Proteins;Proto-Oncogene Proteins c-akt;receptor;Receptor Signaling;Regulation;response;RNA;Role;Route;Seminal fluid;Signal Transduction;Stimulus;System;systemic inflammatory response;Technology;Tight Junctions;Tissue Engineering;tool;Tracer;Transcriptional Regulation;vaping THC;Vascular Cell Adhesion Molecule-1;Viral;Viremia;Virus;Virus Replication

PROJECT_TITLE: The role of cannabinoids in the regulation of the blood brain barrier in the context of NeuroHIV and anti-retroviral therapy


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The proposed research is relevant to public health because developing strategies to directly monitor calcium signaling and neurotransmitter release will significantly advance fundamental knowledge of how neurons communicate with each other. The contribution will be highly significant because dysregulation of Ca2+ signaling is a key early–stage process of neurodegeneration in age-related retinal degenerations, glaucoma, diabetic, and optic neuropathies. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: VAITHIANATHAN, THIRUMALINI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adult;age related;analog;Biological Models;Biology;Calcium Signaling;Cells;Central Nervous System;Communication;Complex;Computer Models;cytomatrix;Data;Defect;Development;diabetic;Diabetic Neuropathies;disability;Disease;Electron Microscopy;Electrophysiology (science);fluorescence imaging;Future;Glaucoma;Goals;Health system;Homeostasis;Human;Individual;Investigation;Kinetics;Knowledge;Laboratories;luminance;Measures;millisecond;Mission;Molecular;Molecular Target;Monitor;Nerve Degeneration;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;optic nerve disorder;Organelles;pharmacologic;Physiological;prevent;Process;programs;Property;Proteins;Public Health;rate of change;recruit;Regulation;Research;Retina;Retinal Degeneration;Retinal Diseases;ribbon synapse;Rod;Role;segregation;Sensory;Signal Transduction;Site;spatiotemporal;Speed;stem;Stimulus;Synapses;Synaptic Transmission;Synaptic Vesicles;Techniques;Testing;therapeutic development;Therapeutic Intervention;tool;transmission process;United States National Institutes of Health;Vesicle;Vision;visual control;visual information;visual stimulus;Visual System;voltage clamp

PROJECT_TITLE: Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Melanoma has an unusually high propensity to metastasize to the brain and these brain metastases have extremely poor prognosis and limited treatment options. In the brain microenvironment, melanoma cells are frequently found invading deep into the cortex by traveling along the perivascular surface of blood vessels and this vascular-tropic pattern of growth is associated with poor survival in melanoma patients. The experiments in this proposal will explore the contributions of a perivascular-induced TGFβ-PDGFRβ signaling axis and how this signaling cooperates with PTEN loss to sustain invasion and survival in the brain; insights into these mechanisms provide an opportunity to guide the development of unique vascular-directed strategies to prevent or treat brain metastases.

PI_NAMEs: WANG, SARAH C (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adhesions;Adopted;angiogenesis;ANXA5 gene;Apoptosis;Apoptotic;Attenuated;Autopsy;Biology;Blood Vessels;Brain;brain endothelial cell;Brain Injuries;cancer therapy;CASP3 gene;Cell Death;Cell Line;Cells;Cerebral endothelium;cerebrovascular;Cerebrovascular system;Cicatrix;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Data;Dependence;Development;differential expression;Disease;Drug resistance;Endothelial Cells;Endothelium;experimental study;field study;Genes;Goals;Growth;Human;Image;imaging platform;Immunotherapy;improved;In Vitro;in vivo;Injections;insight;intravital imaging;Invaded;Knock-out;Ligands;Malignant neoplasm of brain;MAP Kinase Gene;Measures;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Mentors;Mesenchymal;Metastatic malignant neoplasm to brain;Metastatic Melanoma;migration;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Morphology;mortality;Motility;mutant;Neoplasm Metastasis;neuronal survival;Neurons;neuroprotection;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Pattern;Pericytes;Phenotype;PI3K/AKT;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;prevent;Process;Production;Prognosis;Proliferating;protective factors;PTEN gene;quantitative imaging;Resistance;Risk;Rodent Model;Role;Sampling;Scientist;Serum;Signal Transduction;single-cell RNA sequencing;Slice;Stains;Surface;System;targeted treatment;Testing;therapeutic development;Transforming Growth Factor beta;Travel;treatment comparison;tumor;tumor microenvironment;Tumor Suppressor Proteins;Up-Regulation;Work

PROJECT_TITLE: Mechanisms of perivascular melanoma dispersal and survival in the brain


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: Treatments for atrial fibrillation, which affects ~6% of Americans who are 65 years of age and older, are limited by the suboptimal efficacy and toxicities of pharmaceuticals and radiofrequency ablation/surgery, and high rates of recurrence. We now apply innovative proximity labeling, novel mouse models, and groundbreaking cryo-EM high-resolution imaging and structural biology studies of the human recombinant RyR2 channel to elucidate mechanisms responsible for atrial arrhythmias and reduced contractility. Thus, the proposed research is relevant to public health and to the NIH mission to discover basic mechanisms underlying human disease.

PI_NAMEs: MARKS, ANDREW ROBERT;MARX, STEVEN O (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Adrenergic Agents;Adrenergic Agonists;Adrenergic beta-Agonists;Affect;Alanine;American;Amino Acids;Anterior;Arrhythmia;Arteries;ascorbate;Atrial Fibrillation;Binding Sites;Biotin;Cardiac Myocytes;Cardiomyopathies;catalase;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congestive Heart Failure;Coupling;Crossbreeding;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Cysteine;Development;Disinhibition;Dissection;Electrophysiology (science);FKBP1B gene;Forskolin;Funding;Goals;Heart;Heart Atrium;Heart failure;high resolution imaging;Human;human disease;human old age (65+);In Situ;in vivo;Inherited;inhibitor;innovation;insight;Ion Channel;Knock-in;Knock-in Mouse;Label;Lead;Left;Ligase;Ligation;Lipid Bilayers;Macromolecular Complexes;Maps;Mass Spectrum Analysis;Mediating;Membrane Potentials;Methods;Mission;Mitochondria;Molecular;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutate;Neighborhoods;novel;novel therapeutics;Operative Surgical Procedures;oxidation;Oxidative Stress;Pathogenesis;Pathologic;Patients;Peroxidases;Pharmacologic Substance;Phosphorylation;Phosphorylation Site;Physiological;Physiology;prevent;Protein Isoforms;Public Health;Radiofrequency Interstitial Ablation;Rattus;Reactive Oxygen Species;Recombinants;Recurrence;Regulation;Research;Resolution;Risk;Role;Ryanodine Receptor Calcium Release Channel;RyR1;Sampling;Sarcoplasmic Reticulum;Signal Pathway;Signal Transduction;Skeletal Muscle;Specificity;structural biology;Structure;Tacrolimus Binding Protein 1A;Testing;three dimensional structure;Toxic effect;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;voltage

PROJECT_TITLE: Exploring the Molecular Physiology of Atrial Fibrillation

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Bioengineering;Genetics

PHR: Narrative The correct segregation of the genomic material during cell division is an important process, which is fundamental to life, and any segregation error has severe implications for the organisms. By providing unique and novel information on the spindle structure and function, we will gain a better understanding of the forces and mechanisms involved in the process of chromosome segregation and ultimately healthy mitotic spindles. The data acquired in the frame of this proposal will be valuable to identify new therapeutic approaches and targets.

PI_NAMEs: REDEMANN, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3-Dimensional;Anaphase;Automobile Driving;Bundling;Cell division;Cells;chromosome movement;Chromosome Segregation;Chromosomes;Complement;Coupled;Data;daughter cell;Development;electron tomography;Failure;Generations;Genetic;genetic approach;Genomics;Goals;Growth;Guanine Nucleotide Exchange Factors;Health;Human;Individual;insight;Kinesin;Kinetochores;Length;Life;life span;Light;light microscopy;Malignant Neoplasms;mathematical model;Mathematical Model Simulation;Measurement;Metaphase Plate;Microscopic;Microtubule Bundle;Microtubule Polymerization;Microtubules;Mitosis;Mitotic spindle;Modeling;Molecular;Monitor;Motor;mutant;Nature;new therapeutic target;novel;novel therapeutic intervention;Optics;Organism;Pathway interactions;Play;Plus End of the Microtubule;polymerization;Polymers;Positioning Attribute;prevent;Process;Property;Proteins;Publications;recruit;Regulation;Research;Resolution;RNA Interference;Role;Running;segregation;Sister Chromatid;Slide;Solid;Source;Structure;System;targeted cancer therapy;Testing;Time;tomography;Visualization

PROJECT_TITLE: The role of microtubule dynamics in midzone driven chromosome segregation in anaphase

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE While Brain-Computer Interfaces (BCIs) have achieved remarkable progress over the last decade, the dexterity of current brain-controlled bionic hands is limited by a lack of understanding of (1) how posture and forces of the arm and hand are encoded in primary motor cortex and (2) how manual interactions with objects are encoded in primary somatosensory cortex during active control. To fill these gaps, we will characterize the sensorimotor representations of the limb during a variety of prehensile behaviors (reach, grasp, transport) and leverage these results to develop next-generation motor decoding and sensory encoding algorithms for brain-controlled bionic hands.

PI_NAMEs: COLLINGER, JENNIFER L.;GAUNT, ROBERT A;HATSOPOULOS, NICHOLAS G (contact);KAUFMAN, MATTHEW TYLER;MILLER, LEE

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;active control;Address;advanced analytics;Algorithms;Animals;Area;arm;arm movement;Artificial Arm;Behavior;Behavioral;Biomimetics;Bionics;Brain;brain computer interface;Clinical Trials;Code;Communication;Complex;Consensus;Cutaneous;Deafferentation procedure;design;Development;dexterity;Digit structure;dynamic system;Elbow;Event;Exclusion;experience;experimental study;Feedback;Funding;grasp;Hand;Hand functions;Human;improved;Individual;insight;kinematics;Limb Prosthesis;Limb structure;Manuals;Maps;Measures;microstimulation;Monitor;Monkeys;Motor;motor behavior;Motor Cortex;motor learning;Movement;neural;neuromechanism;neuronal patterning;Neurons;neuroprosthesis;next generation;nonhuman primate;novel;Participant;Play;Population;Posture;Research;response;restoration;Robotics;Role;Sensory;Shapes;Shoulder;Signal Transduction;Site;Skin;Somatosensory Cortex;Stimulus;success;Systems Analysis;Tactile;Techniques;Test Result;Texture;Time;Touch sensation;transmission process;United States National Institutes of Health;Wrist;wristband

PROJECT_TITLE: The interplay between kinematic and force representations in motor and somatosensory cortices during reaching, grasping, and object transport

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

PHR: The proposed resource will continue to provide state-of-the-art facilities with unique capabilities for muscle/fiber diffraction and macromolecular SAXS to the bio-medical and structural biology community. Through our fiber diffraction program, we hope to illuminate the mechanisms behind pathologies such as inherited cardiomyopathies, traumatic brain injury, and cancer metastasis. The SAXS program studies molecular complexes essential for cell function including those involved in human pathologies and can provide rational bases for drug design.

PI_NAMEs: IRVING, THOMAS C (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Advisory Committees;Aging;Amyloid;Automation;base;beamline;Biochemical;Biocompatible Materials;Biological;biological systems;Biology;biophysical properties;Biophysics;Biotechnology;Cardiomyopathies;Cell Physiology;Cells;Charge;Collaborations;Communities;community organizations;Complex;Computer software;computerized data processing;Connective Tissue;Data;data acquisition;Data Analyses;data quality;Dedications;Development;disease model;Drug Design;Educational workshop;Ensure;Equilibrium;Equipment;Evolution;experience;experimental study;Fiber;fibrous protein;Funding;Grant;Human Pathology;Illinois;Image;improved;Individual;Infrastructure;inherited cardiomyopathy;Instruction;instrumentation;interest;Laboratories;Leadership;Ligands;Light;macromolecule;Maintenance;Mission;Modification;Molecular;Molecular Biology;Molecular Sieve Chromatography;Muscle;Myocardium;National Center for Research Resources;National Institute of General Medical Sciences;Neoplasm Metastasis;Noise;Nucleic Acid Folding;Nucleic Acids;operation;outreach;Pathology;Persons;Photons;Physics;Physiological;Policies;prevent;Principal Investigator;Productivity;professor;programs;protein structure;Proteins;Publications;Radiation induced damage;Recruitment Activity;repaired;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Sampling;Scanning;Schedule;Science;Shapes;Signal Transduction;Site;Skeletal Muscle;Source;structural biology;Structure;Students;symposium;synchrotron radiation;Synchrotrons;System;Technology;Time;Tissue Sample;tool;Training;Training Activity;training opportunity;Traumatic Brain Injury;United States National Institutes of Health;Update;user-friendly;Visit;web site;X ray diffraction analysis

PROJECT_TITLE: The Biophysics Collaborative Access Team


PROJECT_TERMS: Accounting;Advisory Committees;Annual Reports;Award;beamline;Biohazardous Substance;Biological Sciences;Biophysics;Chicago;Collection;college;Containment of Biohazards;Contracts;Development;Documentation;Education and Outreach;Grant;Human Resources;Illinois;Laboratories;Maintenance;operation;Photons;Preparation;Procedures;programs;Reporting;Research;Resources;Safety;Schedule;Scheduling and Staffing;Science;Source;Synchrotrons;System;Technology;Time;United States National Institutes of Health

PROJECT_TITLE: The Biophysics Collaborative Access Team (Admin - Core)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-T]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Public Health Relevance Approximately 2 billion people worldwide are chronically infected with T. gondii and harbor tissue cysts in their organs and tissues, and thus are at risk of reactivation should their immune system decline. Existing drugs suffer from toxicity, allergic reactions and are unable to eliminate chronic infection. The proposed research will identify new drug candidates for eradicating chronic infection, including within the central nervous system.

PI_NAMEs: CHATTERJEE, ARNAB KUMAR;SIBLEY, L. DAVID (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Achievement;Acute;acute infection;Allergic Reaction;Amino Acyl-tRNA Synthetases;analog;Animal Model;Animals;azetidine;Biological Assay;Biological Availability;Brain;Cells;Central Nervous System;Central Nervous System Toxoplasmosis;chemical synthesis;Chemicals;chemotherapy;Chronic;chronic infection;Clinic;Clinical Research;congenital infection;Cyst;Data;design;Disease;drug candidate;Drug Kinetics;efficacy testing;Enzymes;Eye diseases;Fetal Development;Future;genetic approach;Genomic approach;Goals;Growth;high throughput screening;Human;immune function;Immune system;Immunity;Immunocompetent;Immunocompromised Host;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infant;Infection;Infection Control;inhibitor;Lead;Libraries;Malaria;Metabolic;meter;Methods;Modernization;Monitor;mouse model;nanomolar;novel therapeutics;Opportunistic Infections;opportunistic pathogen;Oral;Organ;Organic Chemistry;Parasites;Parasitic infection;Penetration;Periodicity;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;phenylalanine-tRNA;Placenta;Plasma;Plasmodium falciparum;pre-clinical;Pregnancy;Property;public health relevance;Pyrimethamine;Research;Resistance;Resistance development;Risk;Safety;scaffold;Series;small molecule inhibitor;small molecule libraries;South America;Structure-Activity Relationship;sulfa drug;Sulfadiazine;Teratogens;Testing;Tissues;Toxic effect;Toxoplasma gondii;toxoplasmic encephalitis;Toxoplasmosis

PROJECT_TITLE: Exploiting Diversity-Oriented Chemical Synthesis for Combating Chronic Parasitic Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-S(02)M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Bioengineering;Breast Cancer;Cancer;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Narrative We propose novel statistical tools to elucidate the clinical signiﬁcance of prognostic factors in breast cancer survival and to summarize the residual survival time after breast cancer recurrence. Through the application of the proposed methods, we expect to gain new knowledge about the progression of heterogeneous breast cancer, which will lead to better targeted therapies for patients and advances in breast cancer survival. While the proposed research focuses on breast cancer research, the proposed statistical methods will have a broad applicability for other chronic diseases.

PI_NAMEs: LEE, CHI HYUN  (contact)

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Accounting;Address;Androgen Receptor;anti-cancer research;Attention;breast cancer diagnosis;breast cancer progression;breast cancer survival;cancer recurrence;cancer subtypes;cancer survival;Cessation of life;Chronic Disease;Clinical;clinically significant;Collaborations;Complex;conditioning;Data;Development;Disease;epidemiology study;Event;Failure;flexibility;genetic risk factor;Goals;hazard;Hormonal Risk Factor;implementation facilitation;innovation;Knowledge;Life Expectancy;Life Style;Malignant Breast Neoplasm;Mean Survival Times;Measurement;Measures;Methodology;Methods;Modeling;novel;Nurses' Health Study;Outcome;Patients;Performance;Prognostic Factor;Prognostic Marker;prognostic value;Proportional Hazards Models;Prospective, cohort study;receptor expression;Receptor Signaling;Recurrence;Research;Research Personnel;Residual state;Risk Factors;Role;simulation;Statistical Data Interpretation;Statistical Methods;Structure;targeted treatment;Time;tool;Woman

PROJECT_TITLE: Statistical methods for breast cancer survival using the restricted mean survival time


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Hematology;Human Genome;Infectious Diseases;Sepsis

PHR: Narrative This project explores a novel mitochondria-derived nucleic acid component in cardiomyocytes, R-loop (termed as mtR-loop) which plays an important role not only for cardiomyocyte function but also for inflammation responses of immune cells after sepsis. This proposal incorporates 3D-epigenomic information to unveil the novel mechanism involved in aberrant pathological mtR-loop accumulation during septic cardiomyopathy and provides proof-of-principle that will enable precise engineering of transcription regulation in cardiovascular medicine.

PI_NAMEs: HUANG, WEI  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: 3-Dimensional;Adaptive Immune System;Alternative Therapies;Architecture;Automobile Driving;Binding;Cardiac Myocytes;Cardiomyopathies;cardioprotection;cardiovascular risk factor;Cardiovascular system;Cells;Chromatin;Chronic;Clinical;Clinical Research;Data;Defect;design;Disease Progression;DNA;DNA Methylation;Engineering;Enhancers;Epigenetic Process;epigenome;epigenome editing;epigenomics;experimental study;extracellular;Failure;Functional disorder;Future;Genetic;Genetic Transcription;Genome Mappings;Genomic Instability;Goals;Heart;heart damage;Heart Diseases;Heart failure;heart function;Hybrids;Immune;Immune response;Immune System Diseases;Immunity;Immunotherapy;improved;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;intercellular communication;Intervention;Knowledge;Life;Link;Macrophage;Mediating;Medicine;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitochondrial Matrix;Molecular;Monitor;Morbidity - disease rate;mortality;Mus;Myocardial dysfunction;Names;novel;novel therapeutic intervention;Nucleic Acids;Organ;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Pilot Projects;Play;preclinical study;prevent;Process;promoter;Recovery;Regulation;Reporter;response;RNA;Role;Sepsis;septic;septic patients;Signal Transduction;Signaling Molecule;Stress;Structure;Sumoylation Pathway;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Transcriptional Activation;Transcriptional Regulation;transmission process;Untranslated RNA;uptake

PROJECT_TITLE: Mitochondrial R-loop in sepsis-induced cardiomyopathy

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


PROJECT_TERMS: Access to Information;base;beamline;Biophysics;Collaborations;Communities;Data;Data Analyses;Data Collection;data reduction;Education and Outreach;Educational workshop;Effectiveness;experience;experimental study;Fiber;Goals;Growth;improved;Individual;information gathering;Institution;Internet;Manuals;Monitor;operation;outreach;outreach program;Persons;Photons;Process;Productivity;Property;prospective;recruit;Research;Research Personnel;Research Project Grants;Resources;Sampling;Science;Site;skills;Source;Speed;Techniques;Technology;Time;tool;Training;Training Programs;Underrepresented Populations;Visit;web page;web site

PROJECT_TITLE: The Biophysics Collaborative Access Team (User Training and Outreach)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: The majority of HIV infections occur at a mucosal surface, here we focus on oral transmission which is a worldwide issue. Our goal is to identify early interventions influencing oral transmission, utilizing the SIV- macaque model, that results in optimal virologic and immune outcomes. The long-term goal is to identify early therapeutic approaches for HIV infected individuals that improve immunological and disease outcomes following oral transmission, with potential implications for transmission at other mucosal sites.

PI_NAMEs: SATHER, D. NOAH;SMEDLEY, JEREMY V.;SODORA, DONALD L (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: adaptive immune response;Address;antiretroviral therapy;Breast Feeding;Collaborations;Consumption;Country;Data;design;Disease Outcome;draining lymph node;Dyes;Early identification;Early Intervention;epidemiology study;Event;experimental study;Future;Gastrointestinal tract structure;Goals;HIV;HIV Infections;HIV therapy;HIV vaccine;Hour;Human Milk;Immune;Immune response;Immunity;immunological intervention;Immunologics;improved;improved outcome;Individual;Indocyanine Green;Infant;Infant Health;Infection;Injections;innovation;insight;Interferons;Intervention;intraepithelial;Laboratories;Location;lymph nodes;Lymphatic;Lymphoid;Macaca;Macaca mulatta;Modeling;Morbidity - disease rate;mortality;Mothers;mucosal site;Mucous Membrane;National Institute of Dental and Craniofacial Research;novel;novel therapeutics;Operative Surgical Procedures;Oral;oral HIV;Oral mucous membrane structure;Outcome;penis;rectal mucosa;Rectum;Research;Resources;response;Risk;Route;Sampling;Seminal fluid;Site;SIV;SIV Vaccines;Specificity;Surface;Techniques;Therapeutic;therapeutic evaluation;therapy design;Tissues;transmission process;Vaccination;vaccine delivery;vaccine evaluation;Vaccines;Vagina;Viral;viral DNA;viral RNA;viral transmission;Virus;Virus Diseases;Virus Replication;Woman

PROJECT_TITLE: Influence of viral and immune interventions on early events following oral SIV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(90)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 20 year old;Acceleration;Address;Amyloid;Animal Model;Archives;Area;beamline;Biocompatible Materials;Biological;Biophysics;brain tissue;Collaborations;Communities;Complex;computer infrastructure;Computer software;Connective Tissue;Crystallography;Data;data acquisition;Data Analyses;data analysis pipeline;data infrastructure;data management;data quality;data quality/integrity;data reduction;detector;Diagnostic;Ensure;Equipment;experience;Experimental Designs;experimental study;Feedback;Fiber;fibrous protein;Funding;Hour;human disease;Image;imaging study;improved;Individual;Infrastructure;inherited cardiomyopathy;insight;instrument;instrumentation;International;Maintenance;Metadata;Modality;Modeling;Modernization;Molecular Structure;Muscle;Muscle Contraction;Muscle Proteins;muscular system;Myocardium;Neoplasm Metastasis;Network Infrastructure;Neurodegenerative Disorders;operation;Peer Review;Performance;Procedures;programs;Publications;Quality Control;Recording of previous events;Regulation;Reproducibility;Resource Development;Resources;Roentgen Rays;Sampling;Scanning;Schedule;Seminal;simulation;Site;Skeletal Muscle;Skin;software systems;Source;Striated Muscles;Structure;Synchrotrons;System;Technology;Time;Tissues;Training;Transgenic Animals;Traumatic Brain Injury;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: The Biophysics Collaborative Access Team Fiber Diffraction Core)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Adductor laryngeal dystonia (AdLD) is a disorder that causes uncontrolled spasms of the `vocal cords' during speech, causing severe speaking difficulty and a reduction in quality of life. Although the cause of the disorder is not fully understood and there are no treatments for AdLD that produce long-term benefits, our recent findings have discovered that AdLD is associated with a lack of neural inhibition that may be linked to the spasms. The current study builds on these findings to determine if repetitive transcranial magnetic stimulation (rTMS) is effective for increasing neural inhibition, enhancing voice function and improving quality of life for people with AdLD and other voice disorders or types of dystonias.

PI_NAMEs: KIMBERLEY, TERESA JACOBSON (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;Acoustics;Address;adduct;Affect;Age;Area;Auditory;Award;Body Regions;Brain;Characteristics;Clinical;clinical application;Clinical assessments;Clinical Research;Communication;Communication impairment;Cross-Over Studies;Data;Development;Disease;Dose;Double-Blind Method;Dystonia;Environment;Failure;Focal Dystonias;Frequencies;Functional disorder;General Hospitals;Goals;Grant;Hand;Health Occupations;healthcare burden;Hospitals;Impairment;improved;Individual;innovation;interdisciplinary approach;Interruption;Intervention;intervention effect;Investigation;Knowledge;Laryngeal Diseases;Laryngeal muscle structure;Larynx;Left;Limb Dystonia;Limb structure;Link;Massachusetts;Measures;Mentors;Methodology;Methods;Motor;Motor Cortex;Motor Evoked Potentials;Movement Disorders;Muscle;National Institute on Deafness and Other Communication Disorders;neural;Neural Inhibition;neuroimaging;Neurologic;neuromechanism;neurophysiology;neuroregulation;next generation;noninvasive brain stimulation;novel;Participant;patient oriented;Patients;Pattern;Persons;Phonation;Positioning Attribute;post intervention;pre-clinical;Principal Investigator;Production;Protocols documentation;Quality of life;Randomized;randomized, clinical trials;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;Research Personnel;Research Training;Resources;responders and non-responders;response;Running;safety and feasibility;Severities;Spasm;Spastic Dysphonias;Speech;Symptoms;synergism;Testing;Thyroarytenoid Muscle;Time;Training;training opportunity;Transcranial magnetic stimulation;Translating;Translational Research;Translations;treatment response;vocal cord;Voice;Voice Disorders;Work

PROJECT_TITLE: The effects of neural modulation on phonatory function in laryngeal dystonia

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative This project addresses a critical limitation in social communication rehabilitation for adults with traumatic brain injury, namely the lack of practical, valid, and person-centered clinical assessment tools. This project will address this need by integrating rehabilitation and communication theory with stakeholder perspectives to develop, refine, and evaluate the first social communication clinical assessment tools that are short, valid, and guide person-centered treatment. Valid, reliable, and person-centered social communication assessment is the first step to effective communication rehabilitation.

PI_NAMEs: BYOM, LINDSEY JACQUELYN (contact)

PROJECT_TERMS: Address;Adopted;Adult;Affect;Aphasia;Assessment tool;career development;Caregivers;Clinical;Clinical Assessment Tool;clinical decision-making;clinical implementation;cognitive interview;cohesion;Communication;Communication impairment;communication theory;Communication Tools;Communities;community living;cost;Data;Data Reporting;design;Development;Diagnosis;diagnostic tool;Emergency department visit;Ensure;Evaluation;experience;Facial Expression;Family;Family member;feasibility testing;Goals;health assessment;Impairment;implementation science;improved;Individual;Injury;Inpatients;Interview;K-Series Research Career Programs;Knowledge;Language;Length;Life;Linguistics;Literature;Measurement;Measures;Mediating;Methods;Motivation;National Institute on Deafness and Other Communication Disorders;non-verbal;Outcome;Outcome Measure;Participant;Pathologist;Patient Outcomes Assessments;Patients;person centered;prospective;Protocols documentation;Psychometrics;Qualitative Research;Quality of life;Questionnaire Designs;Questionnaires;recruit;Rehabilitation Centers;Rehabilitation therapy;Reporting;Research;research and development;research clinical testing;Research Methodology;response;Risk;Role;Sampling;Science;skills;social communication;social communication impairment;Social isolation;Speech;stakeholder perspectives;Structure;TBI Patients;Testing;theories;Time;tool;tool development;Training;Translating;Traumatic Brain Injury;treatment center;treatment effect;Treatment outcome;treatment planning;Unemployment;United States National Institutes of Health;Validity and Reliability;verbal;Work

PROJECT_TITLE: Development and Evaluation of a Clinical Assessment Tool of TBI-Related Social Communication


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The neural encoding for human bipedal walking is largely unknown, and yet is important for understanding the pathophysiology of gait disorders in Parkinson’s disease. Here, we study the neural control of gait in Parkinson’s patients already implanted with a novel neural stimulator that can wirelessly stream brain signals during gait in the laboratory and at home. Our proposal seeks to shed light on the mechanistic role of the motor cortical-basal ganglia network dynamic in regulating human walking.

PI_NAMEs: WANG, DORIS DU (contact)

PROJECT_TERMS: Accelerometer;Address;Affect;Basal Ganglia;Behavior;Bilateral;Brain;Brain Stem;Chronic;Complex;Coupling;Cues;Data;Deep Brain Stimulation;Devices;Disinhibition;Dopamine;Electrodes;Electroencephalography;Environment;Feedback;flexibility;Freezing;Frequencies;Functional disorder;Gait;Gait abnormality;Globus Pallidus;Goals;Home;Human;Implant;kinematics;Knowledge;Laboratories;Leg;Length;Limb structure;Locomotion;Measurement;Methodology;Methods;Modeling;Modification;Motion;Motor;Motor Cortex;Musculoskeletal Equilibrium;neural;neural network;neurophysiology;neuroregulation;novel;Output;Parkinson Disease;Pathway Analysis;Patients;Periodicals;Periodicity;Pharmaceutical Preparations;Phase;Positioning Attribute;Postural adjustments;Posture;recruit;Resolution;Role;Scalp structure;sensory feedback;Signal Transduction;Stream;Structure;Structure of subthalamic nucleus;System;Testing;theories;Therapeutic;Variant;Visual;Walking;wearable sensor technology;wireless

PROJECT_TITLE: Cortical basal ganglia network dynamics during human gait control

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Precision Medicine;Prescription Drug Misuse;Substance Misuse

PHR: The U.S. has declared a national public health emergency to combat the current opioid crisis that is causing over 30,000 deaths per year. This project uses new systems genetics approaches, open source genomic data and software, and a new type of hybrid rodent mapping panel to precisely define causal linkages between DNA variation and voluntary oxycodone intake. The results may lead to novel therapeutic targets for treating opioid use disorders.

PI_NAMEs: CHEN, HAO ;SHARP, BURT M (contact);WILLIAMS, ROBERT W.

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: abuse liability;Acceleration;addiction;Adult;Age;Analgesics;analysis pipeline;Animal Model;Anxiety;anxiety-like behavior;Artificial Intelligence;Behavior;Behavioral Model;behavioral phenotyping;Biological Assay;Brain;Brain region;Breeding;Candidate Disease Gene;candidate marker;Cessation of life;Chromatin;Chromosome Mapping;cofactor;cohort;combat;Complex;Computer software;connectome;Consumption;Copy Number Polymorphism;Cues;Data;Data Set;design;DNA;drug action;Drug Addiction;Drug Interactions;Drug Kinetics;Environment;epigenomics;Extinction;Family;forward genetics;Foundations;gene network;Genes;Genetic;genetic approach;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genomic data;Genomics;Genotype;Heritability;Hi-C;Human;Hybrids;Hyperalgesia;Immersion;improved;Inbred Strain;innovation;insertion/deletion mutation;insight;Intake;Letters;Libraries;Link;Mammals;Maps;Measures;Medial;Methods;Modeling;Molecular;Molecular Weight;Morphine;Motivation;multiple omics;National Institute of Drug Abuse;neurogenomics;new therapeutic target;novel;Nucleus Accumbens;open source;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid use disorder;Oral;Oxycodone;oxycodone self-administration;Pain;Pattern;Persons;Pharmaceutical Preparations;Phase;phenome;Phenotype;Play;pleiotropism;Population;pre-clinical;precision medicine;predictive modeling;Predisposition;Prefrontal Cortex;prescription opioid;Procedures;Protocols documentation;public health emergency;public repository;Quantitative Trait Loci;rat genome;Rat Genome Database;Rattus;Recombinant Inbred Strain;Reporting;Research Personnel;Resources;Retrotransposon;reverse genetics;Risk;Rodent;Role;Sample Size;Self Administration;sex;Site;Social Behavior;social deficits;Source;System;Tablets;Tail;Testing;trait;transcriptome;transcriptome sequencing;Twin Studies;Variant;Ventral Tegmental Area;virtual;Virulent;whole genome;Withdrawal

PROJECT_TITLE: Genetics of oxycodone intake in a hybrid rat diversity panel.


PI_NAMEs: CHAKRAVARTHY, SRINIVAS  (contact)

PROJECT_TERMS: Adopted;Automation;beamline;Behavior;Binding;Biochemical;Biocompatible Materials;Biological;biophysical tools;Biophysics;Blood capillaries;Categories;Cell Physiology;Cells;Coenzymes;Collaborations;Communities;Computer software;Data;data acquisition;Data Analyses;data analysis pipeline;Data Collection;Data Storage and Retrieval;design;detector;Development;Enzymes;Equilibrium;experimental study;Funding;Future;Heterogeneity;Human Resources;improved;instrument;instrumentation;interest;International;Ionic Strengths;Ligand Binding;light scattering;Liquid Chromatography;Liquid substance;macromolecule;Maintenance;Microfluidics;Midwestern United States;millisecond;Molecular Sieve Chromatography;multimodality;Network Infrastructure;Nucleic Acid Folding;open data;operation;Performance;Productivity;programs;Proteins;Publications;Radiation induced damage;Recommendation;Recording of previous events;Resource Development;Resources;Roentgen Rays;Sampling;Site;Software Tools;Structural Biologist;Synchrotrons;System;Technology;Time;time resolved data;United States National Institutes of Health;user friendly software

PROJECT_TITLE: The Biophysics Collaborative Access Team (SAXS Core)


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Neuroinvasive herpesviruses are the causative agents of a number of severe diseases including encephalitis, shingles, neonatal infections, and keratitis. The goal of these studies is to develop a working understanding of the unusual multi-step genome delivery mechanism of these viruses that supports their neuroinvasive properties. The long-term goal of this work is the development of advanced resources in the continuing efforts to develop antivirals, vaccines, and viral vectors for repair of in-borne genetic errors and treatment of nervous system associated cancers.

PI_NAMEs: PICKARD, GARY EDWARD;SAVAS, JEFFREY NICHOLAS;SMITH, GREGORY ALLAN (contact);SOLLARS, PATRICIA

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Advanced Development;Afferent Neurons;Alphaherpesvirinae;Animals;Anti-viral Agents;Axonal Transport;Binding;Binding Sites;Biological;Bite;Brain;Capsid;Cell Culture Techniques;Cell Nucleus;Cells;Cellular biology;Complex;Data;defined contribution;design;Disease;DNA Viruses;Dsh protein;Encephalitis;Event;Eye;Family;Family member;Gene Delivery;Genetic;Genome;Goals;Herpes zoster disease;Herpesviridae;Herpesvirus 1;Herpesvirus Type 3;Human Herpesvirus 2;human pathogen;Immunocompetent;in vivo;Individual;Infection;Integration Host Factors;Invaded;Keratitis;latent infection;Link;mad itch virus;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Medical;member;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;Mothers;Mutagenesis;neonatal infection;Nervous System;nervous system infection;neural;Neurons;neuroproteomics;neurovirulence;Newborn Infant;novel;Nuclear;Oncolytic;pathogen;Pattern;Peripheral;permissiveness;Phenotype;Phosphotransferases;Positioning Attribute;programs;Property;Protein Kinase;Proteins;Puncture procedure;recombinant virus;Recombinants;repaired;Resources;Rodent;Role;Simplexvirus;Synapses;Syringes;Technology;tissue tropism;Tracer;trait;Trauma;ubiquitin isopeptidase;Vaccines;Validation;Varicellovirus;vector;Viral;Viral Genome;Viral Vector;Virus;Virus Diseases;virus host interaction;WNT Signaling Pathway;Work

PROJECT_TITLE: Virus-host interactions governing alpha-herpesvirus genome delivery and neuroinvasion

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Toxoplasma gondii is a ubiquitous parasite that chronically infects up to 1/3 of the human population by persistently infecting neurons in the brain. Though asymptomatic in most, this persistence enables the reactivation of T. gondii in patients with acquired immune deficiencies, such as AIDS patients, in whom the infection can be deadly. This work seeks to use stem cell-derived human neurons to develop a molecular understanding of how T. gondii persists in this cell type, ultimately enabling the development of better, curative therapies for those with toxoplasmosis.

PI_NAMEs: CHURKO, JARED ;KOSHY, ANITA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Affect;Anti-viral Therapy;Antiparasitic Agents;antiretroviral therapy;Astrocytes;Benign;Brain;cell type;Cells;Central Nervous System Infections;Cessation of life;Chronic;chronic infection;Clinical;co-infection;Cognition;cognitive function;CRISPR interference;curative treatments;Cyst;cytokine;Data;Development;Disease;DsRed;Engineering;Focal Neurologic Deficits;Foundations;Genetic;Genetic Recombination;Goals;Grant;high reward;high risk;HIV;HIV/AIDS;Human;human pluripotent stem cell;Immune Evasion;Immune response;In Vitro;in vivo;Infection;infection rate;Interferon Type II;Invaded;knock-down;latent infection;Lesion;Mediating;Modeling;Molecular;mouse model;Mus;Neurologic;Neurologic Deficit;Neurons;Outcome;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Population;Populations at Risk;prevent;programs;Proteins;Protocols documentation;Reporter;response;Role;Seizures;STAT1 gene;stem cell biology;stem cells;Survivors;Technology;tool;Toxoplasma gondii;toxoplasmic encephalitis;Toxoplasmosis;Work

PROJECT_TITLE: Identifying human neuron IFN-γ dependent anti-Toxoplasma gondii responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


NIH_SPENDING_CATS: Bioengineering;Physical Activity

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE Muscle-generated force is transmitted to tendon across a specialized interface called the myotendinous junction (MTJ). The MTJ is susceptible to injury due to constant exposure of force during physical activity. The objective of this proposal is to identify how the extracellular matrix and mechanical loading establish and maintain the strong linkage between muscle and tendon as this knowledge will be essential for developing therapies to restore functionality to the damaged MTJ.

PI_NAMEs: CALVE, SARAH  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Amino Acids;Amino Acyl-tRNA Synthetases;Area;Articular Range of Motion;Benchmarking;bone;Cell Communication;cell type;Cells;Chemistry;clinical translation;Coculture Techniques;Collagen;comparison control;Complex;Confocal Microscopy;Connective Tissue;Connective Tissue Cells;course development;Data;defined contribution;Deposition;Development;differential expression;Disparate;effective therapy;Embryo;Embryonic Development;Engineering;Enterobacteria phage P1 Cre recombinase;Event;experience;extracellular;Extracellular Matrix;Extracellular Protein;Fibrin;Forelimb;functional restoration;Gel;genetic manipulation;Growth;Hindlimb Suspension;Immunohistochemistry;In Vitro;in vivo;Incubated;Individual;Injury;Knock-out;Knowledge;Label;Liquid Chromatography;macromolecule;mechanical force;mechanical load;Mechanics;Mediating;Membrane;Metabolic;Methods;Minor;Modeling;Morphology;Motility;mouse model;Movement;Mus;Muscle;Muscle Contraction;Musculoskeletal;Musculoskeletal System;Normal Range;optogenetics;Periodicity;periostin;Physical activity;Population;Predisposition;progenitor;Property;Protein Biosynthesis;Proteins;Proteome;Proteomics;Rodent Model;Role;Signal Transduction;Skeletal Muscle;skills;small hairpin RNA;Sports;stress reduction;Stretching;Structure;Supportive care;tandem mass spectrometry;Technology;Tenascin;Tendon structure;Testing;therapy development;Three-Dimensional Imaging;thrombospondin 4;Tissues;transmission process;Trauma;treadmill training;Virginia;Visualization;Work

PROJECT_TITLE: Extracellular integration of a cohesive myotendinous junction