ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Dental caries is one of the most prevalent chronic diseases in the world and the oral bacterium Streptococcus mutans is the major etiological agent of this multifactorial disease. We recently discovered that S. mutans tolerates unusually high concentrations of zinc by utilizing the ZccE exporter and ZccR regulator pair. Because zinc can be safely delivered in high concentrations via oral healthcare products, a better understanding of the importance of ZccR to dental caries and determination of ZccR structure can help us devise new anti-caries therapies by specifically targeting S. mutans without damaging either host cells or disturbing the bacteria associated with oral health.

PI_NAMEs: PETERSON, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Amino Acids;Animals;anticaries;antimicrobial;ATP phosphohydrolase;Bacteria;Binding;Cadmium;Calculi;Caries prevention;Caring;Cells;Characteristics;Chronic;Chronic Disease;Cobalt;Collaborations;combat;Communicable Diseases;comparative efficacy;Computing Methodologies;coping;Copper;cost;Crystallography;demineralization;Dental caries;Dental Enamel;Dental Plaque;design;Development;Disease;Drug Targeting;druggable target;Educational workshop;Environment;Etiology;experimental study;extracellular;Floods;Functional disorder;Future;Genes;Genetic Transcription;Gingivitis;Glucans;Goals;Growth;Halitosis;Healthcare;Homeostasis;Immune system;immunoregulation;improved;In Vitro;in vivo;individualized medicine;Infection;Infective endocarditis;inhibitor;insight;Invaded;Iron;Knowledge;Lactic acid;Learning;Lesion;Life;Literature;Mammalian Cell;Manganese;Mediating;Medicine;Metalloproteins;Metals;Methodology;microbial;Microbial Biofilms;microbiota;Micronutrients;Modeling;Mutagenesis;Mutation;Names;novel therapeutics;Nutritional Immunity;Oral;oral bacteria;oral biofilm;Oral cavity;Oral health;Organism;Parents;pathogen;Pharmaceutical Chemistry;Play;Poisoning;Polymers;Positioning Attribute;Predisposition;prevent;Prevention;Process;programs;Property;protein function;Proteins;Rattus;Research;response;Role;Series;skills;small molecule inhibitor;Starvation;Streptococcus;Streptococcus mutans;Stress;Structure;Structure-Activity Relationship;student mentoring;Sucrose;Surface;System;Testing;Time;Tooth structure;tooth surface;Toxic effect;toxic metal;Trace metal;Training;Transcriptional Regulation;Treatment Cost;Virulence;Work;Writing;Zinc

PROJECT_TITLE: Determination of structure-function relationships and role in virulence of a MerR-type regulator that mediates zinc tolerance in Streptococcus mutans

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Mitosis is a pivotal point during which a cell divides and gives rise to two genetically identical daughter cells. However, transcriptional programs must also be transmitted to ensure cell identity is properly re-established with each cell division. This proposal will study the molecular mechanisms that allow cells to maintain and faithfully re-establish the proper magnitude of gene expression through mitosis towards understanding how cell fate and identity is encoded.

PI_NAMEs: OPRESCU, STEPHANIE NICOLE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Area;arm;Behavior;Binding;Binding Proteins;Binding Sites;Biological Assay;Candidate Disease Gene;CCAAT-Enhancer-Binding Proteins;Cell division;cell fate specification;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;Data;daughter cell;Deposition;Development;DNA Sequence;DNase I hypersensitive sites sequencing;Elements;Endoderm;Enhancers;Ensure;EP300 gene;Exclusion;GATA1 gene;GATA4 gene;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Histone H2B;histone modification;HNF4A gene;Human Cell Line;human embryonic stem cell;improved;Inherited;insight;Interphase;Knowledge;Liver;Maintenance;Measurement;Measures;Mediating;Memory;Methods;Mitosis;Mitotic;Mitotic Activity;Molecular;Mutagens;Physical condensation;preservation;Process;programs;promoter;Proteins;recruit;Regulatory Element;Research;Residual state;Resolution;Role;small molecule;Specific qualifier value;stem cells;TATA-Box Binding Protein;Therapeutic;Trans-Activators;transcription factor;transmission process

PROJECT_TITLE: The role of cis-regulatory elements in the inheritance of transcriptional memory through mitosis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Patient Safety;Prevention

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The University of Rochester Cancer Center National Cancer Institute Community Oncology Research Program Research Base is a legacy academic Research Base with 35+ years of continuous funding to conduct cancer control research and cancer care delivery research. Working within a large network of community oncology clinics across the United States, the goals of the Research Base and its community partners are to reduce cancer- and treatment-related symptoms and side effects by conducting research with cancer patients, survivors, and their caregivers.

PI_NAMEs: MORROW, GARY R;MUSTIAN, KAREN M. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Achievement;Age;American Society of Clinical Oncology;anti-cancer research;Award;base;Behavioral;Biological;Biological Markers;cancer care;Cancer Center;Cancer Control;Cancer Control Research;Cancer health equity;Cancer Patient;Cancer Survivor;care delivery;Caregivers;Caring;chemotherapy;Clinic;Clinical;Clinical Cancer Center;clinical care;Clinical Oncology;Clinical Research;Clinical Research Associate;Clinical Trials;Cluster randomized trial;Collection;Committee Members;Communities;Community Clinical Oncology Program;Community Networks;community partners;Conduct Clinical Trials;Data;data acquisition;design;Development;Enrollment;Epigenetic Process;Ethics;Ethnic Origin;Etiology;experience;Funding;Gender;gene therapy;Goals;Grant;health disparity;health equity;Health equity research;hormone therapy;human subject protection;Immunologics;Immunotherapy;improved;Individual;innovation;Innovative Therapy;Intervention;intervention delivery;investigator training;Journals;Knowledge;Leadership;Malignant Neoplasms;Manuscripts;Medical Oncologist;member;Mentors;Minority;Minority Groups;Modernization;Morbidity - disease rate;National Cancer Institute;Nature;NCI Center for Cancer Research;novel;Nurses;Oncologist;Oncology;Operative Surgical Procedures;Outcome;participant enrollment;Pathway interactions;Patient Care;Patients;Peer Review;Persons;Phase;Physicians;Physiological;Pilot Projects;Positioning Attribute;Prevalence;Procedures;Productivity;Program Development;programs;Prospective, cohort study;Protocols documentation;psychosocial;Publications;Publishing;Quality of Care;Race;Radiation Oncologist;Radiation therapy;Randomized;randomized, clinical trials;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Resources;Risk;Scientific Inquiry;Severities;Sex Orientation;side effect;Site;stem;Supportive care;Surgeon;Survivors;symptom science;Symptoms;System;system-level barriers;Testing;Toxic effect;Training;treatment guidelines;Treatment Side Effects;Treatment-related toxicity;Underserved Population;United States;Universities;virtual;Vision;Woman;Work

PROJECT_TITLE: URCC NCORP Research Base


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Infertility affects ~48.5 million couples worldwide, and half are due to male factors. This project aims to discover novel mechanisms underlying male reproduction regulated by mitochondrial dynamics. Study findings will provide critical insights into the poorly understood mitochondrial coordination during mammalian germ cell development and may critically inform novel strategies to treat impaired male fertility due to mitochondrial dysfunction.

PI_NAMEs: WANG, YUAN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acceleration;Adult;Affect;Architecture;Area;Biology;Cell Physiology;cell type;Cells;conditional knockout;Couples;Data;Development;Developmental Process;Equilibrium;Event;Fluorescence;Gene Modified;Germ Cells;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Impairment;In Vitro;Infertility;insight;Knockout Mice;male;male fertility;Male Infertility;Mammals;Metabolic;Metabolism;Mitochondria;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial fitness;mouse model;novel;novel strategies;Organelles;Output;Oxidative Phosphorylation;Pattern;Play;postnatal;Process;Reactive Oxygen Species;real time monitoring;Reproduction;Reproductive Medicine;Research;Respiration;Role;Series;Signal Transduction;Somatic Cell;sperm cell;sperm quality;Spermatogenesis;Spermatogonia;stem cell differentiation;stem cell self renewal;stem cells;Testing;Testis;Transplantation;Undifferentiated

PROJECT_TITLE: Mitochondrial dynamics in spermatogonial differentiation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Rural Health

ORG_CITY: SEATTLE

ORG_NAME: SWEDISH MEDICAL CENTER, FIRST HILL

ORG_STATE: WA

PHR: PROJECT NARRATIVE (RELEVANCE) The NCORP Community Site outlined in this continuation application comes from our experience building a multicenter infrastructure in the Western United States that excels in patient accrual and fosters new and close collaboration between investigators. We believe that our structure will accelerate the translation of knowledge gained from trials in cancer treatment, cancer control and prevention, cancer care delivery research, screening, and imaging into clinical practice and thereby enhance the science, the treatments, and the delivery of care to patients with cancer in community settings.

PI_NAMEs: CONLIN, ALISON K;DRESCHER, CHARLES  (contact);ZUCKERMAN, DAN SAYAM

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Address;Advocate;Aftercare;Agreement;Alaska;anti-cancer research;base;California;cancer care;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer therapy;care delivery;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;clinically significant;Collaborations;Collection;Communities;Community Clinical Oncology Program;community setting;Credentialing;data submission;demographics;Disparity;Ensure;Environment;evidence base;experience;feasibility trial;Fostering;Funding;Generations;Goals;health disparity;Idaho;Image;Improve Access;improved;Individual;Infrastructure;Institutional Review Boards;Knowledge;knowledge translation;Legal;Malignant Neoplasms;Medical center;Mentors;Minority Groups;Minority Participation;Montana;National Cancer Institute;next generation;Oregon;Organizational Efficiency;organizational structure;Patient-Focused Outcomes;Patients;Population Heterogeneity;Prevention;Procedures;Process;programs;quality assurance;Quality Control;Research;Research Personnel;research study;Resources;sample collection;Science;screening;Site;Structure;treatment center;trial design;trial enrollment;tumor;Underrepresented Populations;Underserved Population;United States;Washington;Work

PROJECT_TITLE: The Pacific Cancer Research Consortium (PCRC), an NCORP Community Site


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The goals of this project are to obtain preclinical data on the placental transfer of amenamevir and pritelivir and to assess the reproductive hazard of pritelivir in an animal model to determine the potential use of these novel antiherpesviral drugs for treatment of genital herpes in pregnancy.

PI_NAMEs: BRYANT, VALENTINA FOKINA (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: ABCB1 gene;Acute;Acyclovir;Affect;Age;alternative treatment;Animal Model;Birth;Cells;Cessation of life;Childbirth;Choriocarcinoma;clinical development;Congenital herpes simplex;conventional therapy;Data;Development;developmental toxicity;Disease Outbreaks;DNA Primase;drug distribution;Embryo;Endothelial Cells;experience;Experimental Models;Exposure to;fetal;Fetal safety;Fetus;genital herpes;Goals;hazard;helicase;Herpes Simplex Infections;Herpes zoster disease;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;Human Herpesvirus 2;Immunocompromised Host;In Vitro;Incidence;Individual;inhibitor;Investigation;Japan;lipophilicity;Lobule;Mediating;Membrane Transport Proteins;men;Molecular Weight;Morbidity - disease rate;mortality;Mothers;Mus;neonatal infection;neonate;Neurological disability;Newborn Infant;novel;novel therapeutics;nucleoside analog;Oryctolagus cuniculus;Patients;Perfusion;Perinatal transmission;Pharmaceutical Preparations;Pharmacotherapy;Phase II Clinical Trials;Phase III Clinical Trials;Placebos;Placenta;placental transfer;pre-clinical;Pregnancy;pregnant;Pregnant Women;prevent;Prodrugs;Recurrence;Reporting;reproductive;Resistance;response;Risk;Risk Reduction;Role;Safety;safety testing;Simplexvirus;standard care;Techniques;Therapeutic;Time;Tissues;Toxic effect;Toxicokinetics;transmission process;trophoblast;Umbilical vein;United States;valacyclovir;viral transmission;Virus Shedding;Woman;Work

PROJECT_TITLE: Human placental biodisposition of novel antiherpesviral drugs, amenamevir and pritelivir, using ex vivo and in vitro experimental models

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: DETROIT

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: NARRATIVE Compelling evidence indicates that the key to increasing lifespan equality is saving lives at ages below ~70 years. The ACHIEVE GREATER Center is designed to do just that by ameliorating cardiometabolic health disparities during early phases of pathogenesis in order to improve Black-White lifespan inequality in two uniquely comparable, densely populated, and severely affected cities: Detroit, MI, and Cleveland, OH.

PI_NAMEs: LEVY, PHILLIP DAVID (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Affect;Age;Archives;Area;Biological Specimen Banks;black patient;Black Populations;Black race;blood pressure elevation;built environment;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;career;Cause of Death;Censuses;Characteristics;Chronic;Cities;Clinical;cloud based;cohort;Collaborations;collaborative care;Communities;community engagement;Community Health Aides;Community Outreach;comorbidity;Coronary heart disease;cost effective;Data;Data Collection;data management;data warehouse;Databases;density;design;Development;disease disparity;Disparity;Diverse Workforce;Electronic Health Record;Ensure;Environment;epidemiology study;evidence base;Evidence based intervention;extend lifespan;Fostering;Future;Geographic Locations;Goals;Grant;health disparity;health inequalities;Health Services Accessibility;Health system;Heart;Heart Diseases;Heart failure;high risk population;Home;Hypertension;implementation intervention;improved;Incidence;Inequality;informatics tool;Infrastructure;Ingestion;Institution;Interruption;Intervention;Life;life span;Life Style;Location;Mentors;Methods;Michigan;Mobile Health Units;National Institute on Minority Health and Health Disparities;Ohio;outreach;Participant;Pathogenesis;Pathway interactions;Persons;Pharmacists;Phase;Pilot Projects;Policy Maker;Poverty Areas;Practical Robust Implementation and Sustainability Model;Prevention;programs;Public Health;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reduce health disparities;remediation;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Scientist;skills;Social Behavior;social health determinants;social vulnerability;Statistical Data Interpretation;System;Training;Universities;University Hospitals;virtual;Vision;Work

PROJECT_TITLE: ACHIEVE GreatER: Addressing Cardiometabolic Health Inequities by Early PreVEntion in the Great LakEs Region


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PROJECT_TERMS: Address;Adherence;Adult;Attention;Automobile Driving;Awareness;behavior change;Biometry;Black race;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chronic;Cities;Clinical;Clinical Pharmacy Service;Collection;Common Data Element;Communication;Data;data standards;design;Development;disease disparity;Disparity;Early Intervention;economic evaluation;effectiveness evaluation;Ensure;Epidemiology;Fostering;General Population;Geography;Goals;Grant;health economics;health inequalities;Health system;heart disease prevention;implementation science;improved;Informatics;innovation;Institution;Leadership;life span;Maps;Measures;middle age;Mind;Minority Groups;minority investigator;Monitor;mortality;multidisciplinary;next generation;nutrition;Oils;operation;Outcome;Persons;Physical activity;Prevention;Productivity;Program Evaluation;programs;recruit;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Risk Factors;Risk Reduction;Safety;Services;standardize measure;success;synergism;Training;Underrepresented Minority;United States National Institutes of Health;Universities;University Hospitals;urban setting;virtual

PROJECT_TITLE: ACHIEVE Administrative Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BADR, M.SAFWAN  (contact)

PROJECT_TERMS: Address;Advertising;Advisory Committees;Archives;Award;Biological Specimen Banks;Biometry;cardiometabolism;career;Career Mobility;Chronic Disease;Climate;cloud based;cohort;Collaborations;Communities;community engagement;Consultations;cost;Data;data warehouse;Development;Discipline;disease disparity;disorder prevention;Electronic Health Record;Epidemiology;Extramural Activities;forging;Fostering;Functional disorder;Funding;Funding Agency;Funding Opportunities;Goals;Grant;Health;health inequalities;Health system;implementation science;improved;Infrastructure;Ingestion;innovation;Institution;Institutional Review Boards;interest;Letters;life span;Measures;member;Mission;Monitor;Phase;Pilot Projects;Population;population health;Prevention;programs;Publications;Reduce health disparities;Research;Research Design;Research Personnel;research study;Resources;risk mitigation;Secure;skills;sound;success;Testing;Time;Training;Universities;University Hospitals;Vision

PROJECT_TITLE: ACHIEVE Investigator Development Core


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PI_NAMEs: ROSENBLAU, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Academic Medical Centers;Address;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Benchmarking;Brain;Calibration;Categories;Cells;Clinical;clinical practice;clinically relevant;Code;Cognitive;cognitive rigidity;Collaborations;computational neuroscience;computer framework;Computer Models;Decision Making;Dimensions;Disease;Doctor of Philosophy;Dorsal;Evaluation;Exhibits;expectation;experimental study;flexibility;Functional Magnetic Resonance Imaging;German population;Germany;Goals;Grain;Human;Impairment;improved;Individual;Individual Adjustment;individuals with autism spectrum disorder;interest;Knowledge;Learning;learning strategy;Medial;medical schools;mental state;mentalization;mid-career faculty;Modeling;National Institute of Mental Health;neural;Neurons;neuropsychiatric disorder;Neurosciences;New York;novel;Pattern;Personal Satisfaction;Personality;Personality Disorders;Population;preference;Prefrontal Cortex;Probability;professor;programs;Psychiatry;Psychology;recruit;Research;Research Domain Criteria;Research Proposals;Shapes;Side;Signal Transduction;Site;skills;social;Social Adjustment;social deficits;Social Environment;Social Functioning;Social Interaction;social learning;social neuroscience;social space;Specific qualifier value;Stereotyping;Structure;symptomatology;Symptoms;System;Testing;Uncertainty;Universities;Washington

PROJECT_TITLE: CRCNS US-German Research Proposal: Efficient representations of social knowledge structures for learning from a computational, neural and psychiatric perspective (RepSocKnow)


ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal seeks to shed light on the fundamental mechanisms by which proteins interact with each other in order to control the flow of regulatory information in the cell. The project uses yeast as a model system to study how protein domains recognize and bind to short peptide sequences in their interaction partners, which is central to the function of signaling proteins and protein modifying enzymes throughout eukaryotic biology, from yeast to humans. The resulting discoveries about the recognition rules and specificity determinants that control the binding of short peptide sequences will further our understanding of cellular regulation mechanisms relevant to human health and pathology, such as tissue differentiation, neoplastic growth, and drug design.

PI_NAMEs: PRYCIAK, PETER M (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 3-Dimensional;Affinity;Agreement;Benchmarking;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;Biology;Cell division;cell growth regulation;Cell Physiology;Cells;cost;Cyclin-Dependent Kinases;Cyclins;Data Set;Dependence;design;Disease;Docking;Drug Design;Enzymes;Event;experimental study;Family;flexibility;Goals;Growth;Health;high throughput screening;Human;human pathogen;In Vitro;in vivo;inhibitor;Knowledge;Left;Libraries;Link;Measures;Mediating;meter;Methodology;Methods;Molecular;Monitor;Multiprotein Complexes;mutation screening;Neoplasms;Normal Cell;novel;Pathology;Peptides;Phage Display;Pharmaceutical Preparations;Pharmacology;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;preference;protein aminoacid sequence;Protein Binding Domain;protein folding;protein protein interaction;Proteins;Proteome;Proxy;rapid technique;Regulation;Role;screening;Signaling Protein;Site;Specificity;Substrate Interaction;Surveys;Tertiary Protein Structure;Testing;Tissue Differentiation;tool;ubiquitin ligase;ubiquitin-protein ligase;Variant;Viral;Work;Yeasts

PROJECT_TITLE: Comprehensive Analysis of Peptide Motif Binding In Vivo

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: DAILEY, RHONDA K (contact)

PROJECT_TERMS: Address;Air Pollution;Area;building materials;cardiometabolism;cardiovascular health;Censuses;Chemicals;Chicago;Chronic;Cities;cohort;Collaborations;Communities;community academic partnership;community engaged research;community engagement;Community Health Aides;community involvement;community partners;Development;Education;Educational Curriculum;Ensure;Exposure to;falls;Focus Groups;Funding;Generations;Goals;health equity;health inequalities;implementation intervention;implementation process;implementation science;implicit bias;improved;Income;Industrialization;Inequity;Informed Consent;Infrastructure;Intervention;Jordan;Knowledge;Lead;Maintenance;maltreatment;marginalized community;Measures;Medical;Medically Underserved Area;member;Modeling;Monitor;Neighborhoods;Outcome;Outcome Study;Phase;Pilot Projects;poor health outcome;posters;Poverty;Preparation;Prevention;Process;programs;Recording of previous events;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Training;Resources;segregation;Services;Shapes;Site;skills;social health determinants;stressor;symposium;Training;Training and Infrastructure;Training Programs;Translations;underserved community;United States;United States Health Resources and Services Administration;Writing

PROJECT_TITLE: ACHIEVE Community Engagement Core


ED_INST_TYPE: PRIMATE CENTERS

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Maternal Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative: Rising rates of obesity and its complications in pregnancy may be contributing to escalating risk of obesity and chronic disease in the next generation of children. Recent research has shifted obesity management priorities to preconception weight loss, for which bariatric surgery is becoming increasingly more common in women with severe obesity. Findings from this study will provide much-needed evidence about the benefits and risks of preconception maternal weight loss in general, and specifically by achieving this weight loss after bariatric surgery, on long-term childhood health.

PI_NAMEs: BOONE-HEINONEN, JANNE ;PURNELL, JONATHAN Q. (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: 6 year old;absorption;Address;Adult;Affect;Age;Anemia;Animals;Anthropometry;bariatric surgery;Benefits and Risks;Birth;Birth Weight;Blood Pressure;blood pressure elevation;Body mass index;Body Weight;Body Weight decreased;Characteristics;Child;child bearing;Child Health;Childhood;Chronic Disease;Clinical Data;cohort;comorbidity;Conceptions;Control Groups;Cost Analysis;Costs and Benefits;Data;Data Set;disorder risk;ethnic diversity;Ethnic Minority Women;Female of child bearing age;fetal;Future;General Population;Gestational Age;Gestational Diabetes;gestational weight gain;Goals;Growth;Health;high risk;High Risk Woman;Human;Hypertension;improved;Infant;Interdisciplinary Study;interest;Intervention;Life Style;lifestyle intervention;Link;Literature;maternal obesity;maternal outcome;maternal risk;maternal weight;Mediating;Medical;Meta-Analysis;Metabolic;Micronutrients;Minority;Morbid Obesity;Mothers;neonatal outcome;next generation;Obesity;obesity management;obesity risk;obesity treatment;offspring;Operative Surgical Procedures;Oregon;Outcome;Outcome Study;Pathway interactions;Pharmaceutical Preparations;Population Heterogeneity;postnatal;Pregnancy;pregnancy disorder;pregnant;Pregnant Women;prenatal;prepregnancy;Prevalence;primary outcome;racial diversity;racial minority women;Reporting;Research;Risk;Role;Sample Size;Science;secondary outcome;Site;Small for Gestational Age Infant;study population;Subgroup;Universities;Weight;Weight Gain;Woman;Women's cohort

PROJECT_TITLE: Preconception obesity treatment: maternal bariatric surgery and long-term child health outcomes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BROOK, ROBERT DANIEL (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;Adoption;Adult;Advocate;Algorithms;American;Atherosclerosis;black patient;Black race;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care delivery;care systems;Caring;Chronic Kidney Failure;Cities;collaborative care;Communities;Community Health Aides;community partners;Cost Analysis;cost effectiveness;Coupled;COVID-19;Data;Death Rate;Disease;Disparity;Early treatment;Education;Effectiveness;Employment;Environment;Event;evidence base;Evidence based practice;Failure;Familiarity;Goals;Great Lakes Region;Guidelines;Health;health care availability;health disparity;Health education;health equity;health inequalities;health literacy;Health Services Accessibility;Heart;Heart Diseases;Heart failure;High Prevalence;Home;Hybrids;Hypertension;hypertension control;hypertensives;implementation/effectiveness;Improve Access;improved;Individual;Inequity;innovation;Intervention;Length;Life;Life Style;Link;Maintenance;Medical;Methods;mHealth;Mobile Health Units;Modeling;Morbidity - disease rate;mortality;neighborhood disadvantage;novel;Outcome;outreach;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Phase;Practical Robust Implementation and Sustainability Model;prevent;Prevention;primary outcome;Process;programs;Quasi-experiment;racial disparity;Research;Resources;Risk;Risk Factors;Role;social health determinants;social vulnerability;success;Target Populations;Testing;Time;United States;Urban Community;Vaccinated

PROJECT_TITLE: ACHIEVE P1 - HTN


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE The emergence of new technology/media forms has often been accompanied by panic over the likely societal and personal harms they might engender, especially with respect to developing youth. The proposed project seeks to inform our understanding of the particular precursors, correlates, and sequelae that may be linked to the escalating presence of smartphone and social media technologies in teens' lives, and to guide us in determining when these technology habits should, and should not, concern policy-makers and care-givers. The project will enact a multi-methodological cross-sequential longitudinal study to investigate the psychological and brain factors that predispose individuals of different ages to intensified use of smartphones and social media (SSM), and to explore the relationship that such habits may have with specific aspects of cognitive and brain development, psychosocial maturation, and everyday functioning.

PI_NAMEs: CHEIN, JASON M (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acceleration;adjudication;Adolescent;Adolescent and Young Adult;Age;American;Behavior;Behavioral;Biological Assay;Brain;Caring;Cellular Phone;Characteristics;Child;Cognitive;cohort;Data;Development;Diffusion;digital media;Ecological momentary assessment;emerging adult;Esthesia;Exercise;follow up assessment;Future;Growth;Habits;indexing;Individual;Individual Differences;information processing;insight;Investigation;Investments;Laboratories;Link;Literature;Longitudinal Studies;media use;mental function;Methodology;Methods;middle childhood;Modeling;Motivation;neuroimaging;new technology;Outcome;Panic;Pathway interactions;Patient Self-Report;Pattern;Performance;Personal Satisfaction;Phase;Policy Maker;Positioning Attribute;predictive modeling;Predisposing Factor;Process;prospective;psychologic;psychosocial;psychosocial development;Recruitment Activity;Research;reward processing;Rewards;Risk Taking;scaffold;Shapes;skeletal;skills;Sleep;social;social media;Technology;Teenagers;Testing;theories;Traction;Variant;Well in self;Work;young adult;Youth

PROJECT_TITLE: Origins and Outcomes of Smartphone and Social Media Habits Across Development

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: GENETICS

PHR: Narrative While genes are important, an equally important part of our genome is the sequence between genes that controls which genes are switched on or off in each cell of our body, and defects in these “genetic switches” are a major cause of common diseases such as diabetes and cancer. Revolutionary “single cell” methods are allowing scientists to study these genetic switches in thousands of single cells at once, and may lead to the identification of previously unknown types of cells, and to differences between people in the activity of their genetic switches. In this project, we will use a nematode worm as a simple genetic model on which these single cell methods can be improved and comprehensively tested, and get closer to understanding how different cell types arise.

PI_NAMEs: MURRAY, JOHN ISAAC (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 4D Imaging;Adopted;Alleles;Animals;Atlases;Auxins;Biological;Caenorhabditis;Caenorhabditis elegans;cell fate specification;Cell Lineage;Cell Physiology;cell type;Cells;Classification;comparative;CRISPR imaging;Data;Data Set;Defect;Development;Developmental Gene;Diabetes Mellitus;Disease;Embryo;Evolution;experience;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Models;Genetic study;Genetic Transcription;Genome;genome-wide;human tissue;Image;imaging approach;improved;Individual;insight;Malignant Neoplasms;Measures;Mesoderm Cell;Methods;model organism;Modeling;Molecular;Muscle;mutant;Nematoda;novel;Organism;Pattern;Persons;pharmacologic;Pharyngeal structure;progenitor;quantitative imaging;Regulator Genes;Resolution;RNA;Role;Scientist;single cell analysis;single molecule;single-cell RNA sequencing;Site;Specific qualifier value;Switch Genes;System;Testing;Tissues;transcriptome;Trees;Work

PROJECT_TITLE: Comparing cell types across mutants and species at single cell resolution

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Kidney Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LANFEAR, DAVID E (contact)

PROJECT_TERMS: Accounting;Address;Adult;Affect;black patient;Black Populations;Black race;Blood Pressure;blood pressure control;Brain natriuretic peptide;cardiometabolism;care delivery;Caring;Clinical;clinical care;Clinical Trials;collaborative care;Communities;Community Health Aides;community partners;comorbidity;contextual factors;cost;cost effectiveness;COVID-19 testing;Data;Death Rate;Diabetes Mellitus;Disease;Early Intervention;Echocardiography;effective therapy;Effectiveness;Employment;Environment;Event;follow-up;food insecurity;Glucose Transporter;Great Lakes Region;Guidelines;Health;health care availability;health care settings;health disparity;health equity;health inequalities;Health Services;Health Services Accessibility;Heart Abnormalities;Heart Diseases;Heart failure;heart function;Human;Hypertension;hypertensives;implementation barriers;improved;Incidence;Individual;inhibitor;innovation;Intervention;Kidney Diseases;kidney dysfunction;Length;Life;Life Style;Link;Low income;Maintenance;Medical;Methods;Mobile Health Units;neighborhood disadvantage;Neighborhoods;novel;Outcome;outreach;Participant;Patients;personalized intervention;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacotherapy;Phase;Physical activity;Population;Practical Robust Implementation and Sustainability Model;prevent;Prevention;primary outcome;programs;Protocols documentation;Randomized;randomized trial;Recommendation;Recording of previous events;recruit;Reduce health disparities;Renal function;Renin-Angiotensin System;Research;Resources;Risk;Risk Factors;screening;social;social health determinants;social vulnerability;Sodium;standardize guidelines;Target Populations;Testing;treatment optimization;urban setting;Vaccinated;Vaccination

PROJECT_TITLE: ACHIEVE P2 - HF


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Precision Medicine;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RAJAGOPALAN, SANJAY  (contact)

PROJECT_TERMS: Address;Adherence;Adoption;authority;Awareness;Behavioral;black men;black patient;Black Populations;Blood Pressure;built environment;Calcium;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;care coordination;Caring;Catchment Area;Cities;Collaborations;Communication;Communities;Community Health;Community Health Aides;Community Healthcare;community organizations;contextual factors;coronary artery calcium;Coronary heart disease;cost;cost effectiveness;Counseling;Detection;Diabetes Mellitus;Diet;Dimensions;Dose;Education;Effectiveness;effectiveness testing;empowerment;Enrollment;evidence base;experience;Geography;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;Health;health disparity;health inequalities;health outcome disparity;Health Personnel;Health Services Accessibility;Health Technology;healthspan;high risk;high risk population;Home;Home Blood Pressure Monitoring;Housing;Hypertension;improved;improved outcome;Individual;Intervention;intervention effect;Interview;Life;Life Expectancy;life span;Life Style;Life Style Modification;Link;Lipids;Low-Density Lipoproteins;Maintenance;Malignant Neoplasms;Managed Care;Measures;Medical;Mental Health;Methods;metropolitan;Modeling;Monitor;motivational enhancement therapy;multi-component intervention;multidisciplinary;Neighborhoods;novel;Nurses;Obesity;Outcome;outreach;Participant;Pathway Analysis;Pathway interactions;Patients;personalized approach;personalized screening;Pharmaceutical Preparations;Pharmacists;Pharmacotherapy;point of care;Population;Populations at Risk;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Precision Health;precision medicine;Prevention;Process;process evaluation;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Risk;Risk Assessment;Risk Factors;risk perception;scale up;screening;Screening procedure;screening program;Service delivery model;Site;Smoking;smoking cessation;social;social health determinants;Socioeconomic Status;success;Surveys;Technology;Testing;treatment risk;Trust;United States;Universities;University Hospitals;urban area;Urban Health;Visit;vulnerable community;Weight

PROJECT_TITLE: ACHIEVE P3 - CHD


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Disability Research;Hearing Loss;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The proposed research will help clarify the order of influence among emergent literacy constructs for preschoolers with hearing loss compared to preschoolers with normal hearing. These results will inform our theoretical understanding of the impact of hearing loss on emergent literacy development and may lead to the creation of effective interventions to improve literacy outcomes for children with hearing loss. This research is consistent with the mission of the NIDCD because it will help us understand literacy development for children with hearing loss and may lead to improved literacy outcomes for this population.

PI_NAMEs: GRIECO-CALUB, TINA M;INGVALSON, ERIN M (contact);PERRY, LYNN K;VANDAM, MARK

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Child;Child Development;childhood hearing loss;Clinical;Data;Development;effective intervention;elementary school;Future;Goals;hearing impairment;high school;improved;Instruction;Intervention;kindergarten;Knowledge;Language;literacy;Measures;Mission;Modeling;Morphology;National Institute on Deafness and Other Communication Disorders;normal hearing;Nursery Schools;Outcome;peer;phonological awareness;Population;Population Intervention;Preschool Child;programs;Reader;Reading;Research;skills;success;Suggestion;Testing;Theoretical model;theories;Vocabulary

PROJECT_TITLE: Literacy Development for Preschoolers with Hearing Loss

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE UNIVERSITY

PHR: The annual meeting of the American Auditory Society focuses on translating basic research in humans in order to improve the lives of people with hearing and balance problems. Support from NIH will enhance clinical and translational research by promoting synergy among basic scientists, clinicians including physicians and audiologists, and those working in industry in the areas of hearing and balance disorders. Highly successful aspects of the meeting include translational and interdisciplinary research sessions that stimulate thinking, interaction among attendees and promote new research collaborations, travel awards for students/residents to present their research, and career development sessions that provide opportunities for all attendees to enhance their career paths.

PI_NAMEs: PRIEVE, BETH A. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Achievement;Address;American;Applications Grants;Area;Audiology;Auditory;Award;Basic Science;career;Career Choice;career development;Clinical;clinical application;clinical practice;Clinical Research;Clinical Sciences;Collaborations;Data;design;Development;Discipline;Disease;Educational workshop;equilibration disorder;Equilibrium;Feedback;Fertilization;Financial Support;Fostering;Funding;Funding Mechanisms;Future;Goals;graduate student;Grant;Hearing;Hearing problem;Human;Human Resources;improved;Individual;Industry;innovation;Interdisciplinary Study;interest;Investments;Lead;lecturer;lectures;Life;Medical;meetings;member;Mentors;National Institute on Deafness and Other Communication Disorders;next generation;notch protein;Otolaryngology;Outcome;Participant;Persons;Physicians;Postdoctoral Fellow;posters;programs;Published Comment;Qualifying;Questionnaires;Research;research and development;Research Personnel;role model;Science;Scientist;Senior Scientist;Series;Societies;student mentoring;student participation;Students;Suggestion;Surveys;symposium;synergism;technological innovation;Technology;Thinking;Translating;Translational Research;Travel;United States National Institutes of Health;Update;vestibular system;web site;Work

PROJECT_TITLE: Building the Next Generation of Clinical Researchers - American Auditory Society

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative Developmental language disorder (DLD; AKA specific language impairment) results in poor academic and social outcomes and affects 7% of young school age children. Grammatical deficits are hallmarks of this disorder, though sound pattern learning (which emerges in infancy) underlies both grammatical and word learning difficulties experienced by these children. By linking sound pattern learning to both grammatical and word learning deficits, this research will potentially contribute to the earlier identification of children with DLD and also provide new avenues of treatment, and thus is consistent with the mission of the NIH.

PI_NAMEs: GOFFMAN, LISA  (contact)

PROJECT_TERMS: 6 year old;Acoustics;Adult;Affect;Age;Articulation;Automobile Driving;Child;Compensation;Cues;Data;Dependence;Development;Disease;Early identification;Educational process of instructing;experience;Family;Human;improved;infancy;Infant;Intervention;Judgment;Language;Language Development;Language Development Disorders;Learning;Learning Difficulty;Learning Disorders;lexical;lexical processing;Linguistics;Link;Mission;Morphology;novel;Pattern;peer;Performance;phonology;prevent;Production;prototype;Recording of previous events;Research;Rice;School-Age Population;Semantics;sequence learning;skills;Social outcome;sound;specific language impairment;Speech Sound;stem;Subcategory;Testing;Toddler;United States National Institutes of Health;Visual;Vocabulary;Voice;word learning;Work

PROJECT_TITLE: A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In Developmental Language Disorder


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The goal of this Academic-Industrial Partnerships project is to develop, validate, and clinically translate a multimodal intraoral imaging system for oral cancer detection and diagnosis in low resource settings (LRS). Successful completion of this project will lead to the transition of a multimodal intraoral imaging system enabled with deep learning image classification and deliver imperative capabilities to the dental professionals in LRS, significantly reducing the morbidity and mortality of oral cancer.

PI_NAMEs: LIANG, RONGGUANG  (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Accounting;Address;Adopted;Algorithms;Anatomy;Area;Arizona;Benign;Biopsy;California;Cancer Center;Cancer Detection;cancer diagnosis;cancer imaging;cancer prevention;Classification;classification algorithm;Clinical;clinical decision-making;clinical diagnostics;commercialization;cost;cost effective;deep learning;deep learning algorithm;Dental;design;Detection;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic tool;Disease Progression;Dysplasia;Early Diagnosis;Ensure;experience;Faucial pillar;flexibility;follow-up;Goals;Heterogeneity;high risk;Histopathology;Image;image processing;imaging probe;imaging system;Imaging Techniques;impression;improved;India;Individual;industry partner;Infrastructure;innovation;Institution;intraoral probe;Lesion;Light;Location;low and middle-income countries;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Maps;Medical;Methods;miniaturize;Modality;Morbidity - disease rate;mortality;Multimodal Imaging;multimodality;neural network;Nodal;Oncology;Optical Coherence Tomography;optical imaging;Oral;oral care;Oral cavity;Oral Diagnosis;oral dysplasia;oral lesion;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;Output;Participant;Performance;portability;prototype;recruit;Resolution;Resource-limited setting;response;Risk;rural area;Scanning;Schedule;screening;Screening for Oral Cancer;Sensitivity and Specificity;Site;Stage at Diagnosis;standard of care;Survival Rate;System;Systems Integration;Techniques;Technology;tongue root;Training;Translating;Translations;treatment planning;Triage;Universities;user-friendly;Work

PROJECT_TITLE: Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: The mission of the University of Arizona Cancer Center is to alleviate the burden of cancer on patients and families through scientific collaboration and translation; training and education; and bidirectional communication and interaction with the communities of our catchment and beyond.

PI_NAMEs: MERCHANT, JUANITA L. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Affect;Alaska Native;American Indians;anti-cancer research;Arizona;Biomedical Engineering;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Family;cancer health disparity;cancer imaging;Cancer Patient;cancer prevention;cancer research center director;cancer risk;Caring;Catchment Area;Clinical;clinical care;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communities;community engagement;Community Outreach;community partners;convict;Coordination and Collaboration;County;Decision Making;Development;Disparity;diversity and inclusion;Doctor of Philosophy;Education and Outreach;Ensure;Environment;Environmental Exposure;Family;fighting;Fostering;Funding;Funding Opportunities;Generations;Health;health assessment;Health Professional;Hispanic;Hispanic Populations;improved;Incidence;Individual;Inequity;Infrastructure;innovation;interdisciplinary collaboration;Intervention;Intervention Trial;Investments;Leadership;Malignant Neoplasms;member;Mentorship;Methods;Mexico;Mission;mortality;National Cancer Institute;Not Hispanic or Latino;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obesity;Outcome;patient oriented;Patients;Peer Review;Population;population health;prevent;Preventive;preventive intervention;Process;Productivity;programs;Provider;recruit;Research;Research Personnel;Resource Sharing;Resources;Risk Factors;Science;Scientist;screening;Screening for cancer;social;social health determinants;Source;Strategic Planning;Talents;Testing;Training;Training and Education;translational oncology;Translations;Trust;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;working group

PROJECT_TITLE: University of Arizona Cancer Center - Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BANKHEAD, TERI L (contact)

PROJECT_TERMS: anti-cancer research;Arizona;Award;Cancer Center;Cancer Center Support Grant;cancer research center director;Clinical Research;Collaborations;Collection;college;Communication;community engagement;Community Outreach;cost effective;Development;Educational Activities;Ensure;Evaluation;Extramural Activities;Funding;Goals;Grant;Human Resources;Information Technology;Institution;Knowledge;Leadership;meetings;member;Mission;National Cancer Institute;NCI Center for Cancer Research;operation;Operations Research;Play;Policies;Preparation;process improvement;programs;Reporting;Research;Research Infrastructure;Research Support;Resource Sharing;Role;Science;Scientific Advances and Accomplishments;Services;skills;Strategic Planning;symposium;Training and Education;Universities;Vision

PROJECT_TITLE: Administrative Core


PI_NAMEs: SCHWARTZ, JACOB C. (contact)

PROJECT_TERMS: Academia;American Society of Clinical Oncology;anti-cancer research;Appointment;Arizona;Award;Back;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Patient;career;career development;Catchment Area;Clinical Research;clinical training;Databases;Development;Diverse Workforce;Doctor of Philosophy;Educational Activities;Educational workshop;effectiveness measure;ethnic diversity;Extramural Activities;Faculty;Fellowship;Funding;Funding Mechanisms;Government;graduate student;Grant;Health Professional;high school;high school program;Individual;Industry;Institution;K-Series Research Career Programs;Learning;Learning Module;Malignant Neoplasms;Medical Students;meetings;member;Mentors;mid-career faculty;minority trainee;Mission;NCI Center for Cancer Research;next generation;Online Systems;operation;Outcome;Population Scientist Supplement (R25);Postbaccalaureate;Postdoctoral Fellow;prevent;programs;Publishing;racial diversity;recruit;Reporting;Research;Research Personnel;Research Training;Science;science teacher;Series;Site;skills;summer internship;symposium;tool;Training;Training and Education;Training Programs;Training Support;Translational Research;Travel;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Cancer Research Training & Education Coordination (CRTEC)


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Cancer cells rewire their metabolic programs to support tumor growth. We found that metabolic pathways to manage nutrient and redox stress are activated in pancreatic cancer, and that these may represent targetable vulnerabilities. This research proposal will study the mechanisms by which metabolic stress is regulated to define new drug targets and therapies for pancreatic cancer.

PI_NAMEs: LYSSIOTIS, COSTAS ANDREAS (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Anabolism;Apoptosis;Biological Assay;cancer cell;Cancer Etiology;Carbon;Cause of Death;Cell Death;Cells;Cessation of life;Chemicals;Clinical Treatment;Cysteine;Cysteine Metabolism Pathway;Data;Dependence;Diet;Disease;Drug Targeting;effective therapy;Environment;Enzymes;Equilibrium;Exhibits;experimental study;extracellular;Fibroblasts;Foundations;Genetic;Genetic Models;Genetic Techniques;Glutamates;Glutathione;Growth;Human;Immunotherapy;Impairment;In Vitro;in vivo;Incidence;inhibitor;insight;interest;Iron;knock-down;Knock-out;Lipid Peroxidation;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;metabolomics;Methods;mitochondrial metabolism;Modeling;mouse model;Mutation;NADP;new therapeutic target;novel therapeutic intervention;Nutrient;Oxaloacetates;Oxidation-Reduction;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pre-Clinical Model;Process;programs;Property;protective pathway;Reactive Oxygen Species;Regulation;Research Proposals;Resistance;Role;Safety;stable isotope;Stress;stressor;Sulfur;Survival Rate;Techniques;Testing;Therapeutic;three dimensional cell culture;Transaminases;translational potential;Translations;Treatment Efficacy;tumor;tumor growth;United States;uptake

PROJECT_TITLE: Targeting metabolic stress to induce pancreatic tumor cell death

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

PI_NAMEs: ELLIS, NATHAN A. (contact)

PROJECT_TERMS: Agonist;American Indians;androgen independent prostate cancer;Androgen Receptor;Area;Arizona;Award;base;Biological;Biological Markers;Biological Process;Bone Pain;Breast;Breast Cancer Patient;Businesses;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer initiation;cannabinoid receptor;Catchment Area;cell growth;Cell Proliferation;Cells;Cementation;Centrosome;Chelating Agents;Clinic;Clinical Oncology;clinical translation;Coculture Techniques;Collaborations;college;Colon Carcinoma;Combined Modality Therapy;Complex;Country;Defect;design;Development;Direct Costs;Disease;DNA Repair;Educational workshop;Epidermal Growth Factor Receptor;Estrogen Receptors;Ethnic Origin;Ethnic Population;Etiology;European;Faculty;Focus Groups;Fostering;Fumarate Hydratase;Funding;Future;gastrointestinal;gene environment interaction;Gene Expression;Genetic;Genomic Instability;Glycogen (Starch) Synthase;Goals;Grant;Helicobacter pylori;Hepatobiliary;High School Student;Hispanic;Immune;Immune Evasion;Immune system;innovation;Institution;Integrin alpha6beta1;inter-institutional;International;Invaded;Iron Chelation;Knowledge;Lead;Leadership;Legal patent;Link;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;mechanical drive;meetings;member;Mentors;Mentorship;Molecular;molecular subtypes;Mutation;National Cancer Institute;NCI-Designated Cancer Center;Neoplasm Metastasis;new therapeutic target;next generation;Normal Cell;novel therapeutics;oncology program;Organoids;Pathway interactions;Peer Review;Peptides;Phosphotransferases;physical property;Play;Population Heterogeneity;Process;programs;Prostate;protein TDP-43;Publications;racial population;recruit;Renal Carcinoma;Research;Research Personnel;Research Project Grants;Rest;RNA;Role;Science;social;Source;specific biomarkers;stress granule;survivorship;Testing;therapeutic biomarker;therapeutically effective;trafficking;Training;Translating;translational oncology;Translational Research;tumor;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Cancer Biology Program (CBP)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Forty years after the onset of the HIV/AIDS pandemic, still more than 2,000 people per day die of HIV globally. The virus is 100% fatal and, while there are medications that improve and prolong life, there are no cures and no vaccines. We are developing a new model organism that will transform research on the transmission of HIV- 1 and serve as a model for HIV-1 vaccine and cure development.

PI_NAMEs: SAWYER, SARA  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: acute infection;Animal Model;Animals;Antibodies;awake;Award;Binding;Biological Assay;Biological Models;Biology;Blood;Breeding;Bypass;Capsid;CCR5 gene;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;Characteristics;Clinical Trials;cofactor;cross-species transmission;Cyclophilins;design;Development;Diagnostic;Educational process of instructing;Engineering;Epitopes;Event;Future;Genome;Goals;Grant;HIV;HIV Genome;HIV Infections;HIV vaccine;HIV-1;HIV-1 vaccine;HIV-2;HIV/AIDS;Human;Human body;Immunity;Immunocompetent;improved;in vivo;Infection;insight;Integration Host Factors;Learning;Lentivirus;Life;Macaca;Minor;model organism;Modeling;Modification;Molecular;Monkeys;Mutation;National Institute of Drug Abuse;Night Monkey;pandemic disease;pathogen;Persons;Pharmaceutical Preparations;Physiological;Point Mutation;Primates;Reagent;receptor;Research;seroconversion;Serum;simian human immunodeficiency virus;T-Lymphocyte Epitopes;Testing;Time;tool;transmission process;vaccine development;Vaccines;Vertebral column;Viral Genome;viral transmission;Virus;virus host interaction;Virus Replication;Zoonoses

PROJECT_TITLE: Characterizing Host-Virus Interactions in a New HIV Model Organism

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: RELEVANCE Fetal organ development is an intensely physical process that requires coordinated signaling between developing tissues and their surrounding microenvironment to ensure maturation prior to birth. Defects in the timing of morphogenesis or differentiation result in suboptimal organ function and are associated with birth defects and chronic diseases later in life. Here we present a unique combination of experimental approaches to test the innovative hypothesis of a “mechanical clock” that controls the rates of lung, kidney, and pancreas development.

PI_NAMEs: NELSON, CELESTE M (contact)

PROJECT_TERMS: Adult;Animals;Asthma;Biochemical;Biology;Birth;Cells;Chronic Disease;circadian pacemaker;Complement;Congenital Abnormality;Coupled;Coupling;Defect;design;Development;Diffusion;Disease;Distant;Embryo;Embryonic Development;Ensure;Environment;Epithelium;Event;extracellular;fetal;Fetal Development;Fetus;Frequencies;Genetic Transcription;Human;Image;innovation;Kidney Failure;Knockout Mice;Life;Liquid substance;Lung;lung development;mechanical force;Mechanics;Microfluidics;Modeling;Molecular;Morphogenesis;mouse model;Muscle Contraction;nephrogenesis;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Organ;organ growth;organ on a chip;pancreas development;Patients;Periodicals;physical process;premature;pressure;Process;Proliferating;Proteomics;Pulmonary Emphysema;Reporter;Sampling;Segmentation Clock Pathway;Signal Pathway;Signal Transduction;Smooth Muscle;stem cell differentiation;Stereotyping;Stimulus;Testing;Time;Tissues;transcriptomics;Transgenic Organisms;transmission process;Work;zygote

PROJECT_TITLE: Mechanical Clocks During Fetal Development


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Vaccine Related

PI_NAMEs: BEA, JENNIFER WRIGHT (contact)

PROJECT_TERMS: Address;Adopted;Aftercare;American Indians;anti-cancer research;Area;Arizona;Award;base;Behavioral;Biological Markers;Biomedical Engineering;Breast;Breast Cancer survivor;Broccoli - dietary;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Control Research;Cancer Control Research Program;Cancer Detection;cancer health disparity;Cancer health equity;cancer imaging;cancer prevention;cancer risk;Carcinogens;Caregivers;Catchment Area;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;Clinical Trials Network;Collaborations;Country;Detection;Development;Direct Costs;Dissemination and Implementation;dissemination science;DNA Methylation;Dose;Drug Metabolic Detoxication;early phase clinical trial;Environment;evidence base;exercise physiologist;fire fighter;Funding;Future;Goals;Grant;Guidelines;Health;Health Promotion;Hispanic Populations;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;imaging system;Imaging technology;implementation science;improved;improved outcome;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;investigator-initiated trial;Latina;Lead;Legal patent;Malignant Neoplasms;Melanoma;member;methylation pattern;Microscope;Mission;National Cancer Institute;National Cancer Program;neoplasm registry;non-invasive imaging;Not Hispanic or Latino;novel;novel strategies;novel therapeutic intervention;Occupational Malignant Neoplasm;Organizational Policy;Participant;Peer Review;Policies;Population;preadolescence;Preventive;preventive intervention;programs;psychosocial;Publications;Recording of previous events;recruit;Renal Carcinoma;Reporting;Research;Resource Sharing;Risk Factors;Scientist;Screening for cancer;Series;Site;skin cancer prevention;Source;Statutes and Laws;Structure;Survivors;symptom management;System;Tobacco Use Cessation;Tobacco-Associated Carcinogen;United States National Institutes of Health;Universities;Vaccination;wasting;working group;World Health Organization;X-Ray Computed Tomography

PROJECT_TITLE: Cancer Prevention and Control Program (CPCP)


PI_NAMEs: NAWROCKI, STEFFAN T (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;afamelanotide;Animal Model;Arizona;arm;Autophagocytosis;Award;base;Biochemistry;Biological Markers;biomarker driven;bone;Bone Marrow Transplantation;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer therapy;Catchment Area;Cell model;Chemoprevention;Clinic;Clinical;clinical application;clinical development;clinical efficacy;Clinical Oncology;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;Collaborations;Conduct Clinical Trials;Country;design;Detection;Development;Diagnosis;Direct Costs;Disease;Doctor of Philosophy;Dronabinol;drug development;drug discovery;efficacy testing;Engineering;Enrollment;Evaluation;FDA approved;functional genomics;Funding;Glioblastoma;Goals;graft vs host disease;Grant;Head and Neck Cancer;Human;human subject;Image;imaging approach;imaging biomarker;imaging modality;inhibitor;innovation;Institution;instrumentation;inter-institutional;Intervention;invention;investigator-initiated trial;Iron;Laboratories;Lead;lead optimization;Legal patent;Malignant Neoplasms;Medical Oncologist;member;Metastatic breast cancer;Mission;Monoclonal Antibodies;Names;National Cancer Institute;NCI-Designated Cancer Center;New Agents;new therapeutic target;Nitric Oxide;novel;Oncogenic;oncology program;Opiate Addiction;Pain management;Patients;Peer Review;Pharmaceutical Preparations;Population;prevent;Program Development;programs;Publications;Radiation therapy;Scientist;Signal Transduction;Skin;Source;Structure;Systemic Therapy;therapeutic development;Tissues;Translating;translational clinical trial;translational oncology;translational pipeline;Translational Research;translational scientist;translational therapeutics;Translational trial;Translations;treatment trial;tumor;United States National Institutes of Health;Universities;UV Mutagenesis;working group

PROJECT_TITLE: Clinical and Translational Oncology Program (CTOP)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This implementation science study utilizes the multiphase optimization strategy (the MOST framework) to comprehensively optimize and evalulate implementation strategies to improve PrEP adherence among young women (≤24 years) at high risk for HIV acquisition in South Africa. The design (1) leverages existing programmatic data and interventions along with the strategic collection of de novo data to inform implementation adjustments intended to promote PrEP uptake, adherence and persistence, then (2) optimizes the existing interventions through modifications of actor/intensity/duration, evaluating the overall effectiveness of these approaches in two short-duration cluster randomized trials embedded within the existing program infrastructure. Finally, population effectiveness and cost-effectiveness of the implementation strategies will be estimated through tranmission modeling to inform PrEP scale-up for women in South Africa.

PI_NAMEs: SCHWARTZ, SHEREE RENAE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adoption;Advertising;Age;aged;AIDS prevention;Awareness;Behavioral;Biological;Caring;cluster randomized design;Cluster randomized trial;Collection;Communities;condoms;cost;cost effectiveness;Cost Effectiveness Analysis;Country;Couples;critical period;Data;design;economic evaluation;Effectiveness;empowerment;Epidemic;Epidemiologist;experience;Family;Female Adolescents;female sex worker;Friends;Funding;Generations;Goals;Government;Health;health literacy;Health Personnel;Heterosexuals;high risk;High Risk Woman;HIV;HIV risk;HIV/TB;Human immunodeficiency virus test;implementation science;implementation strategy;improved;Incidence;Individual;Infection;Infrastructure;interest;Interruption;Intervention;marginalization;mathematical model;Mathematics;Measures;Methods;Modeling;Modification;multiphase optimization strategy;Nonprofit Organizations;Outcome;peer;peer support;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevent;Prevention;prevention effectiveness;programs;Provider;Province;recruit;relative cost;relative effectiveness;Research Design;response;Rewards;Risk;scale up;Scientist;Self Efficacy;sexual risk behavior;side effect;Site;social influence;social media;social stigma;Social support;South Africa;South African;Southern Africa;Time;Time Series Analysis;tool;transmission process;uptake;Validation;Woman;Work;young woman

PROJECT_TITLE: Optimizing PrEP implementation and effectiveness among women at high risk for HIV acquisition in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Skin Cancer;Social Determinants of Health

PI_NAMEs: YELLOWHAIR, MONICA  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Alaska Native;American Indian community;American Indians;Area;Arizona;Awareness;bilingualism;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Caring;Catchment Area;Centers for Disease Control and Prevention (U.S.);clinical care;Clinical Services;Clinical Trials;Collaborations;Communities;community advisory board;community center;community engagement;Community Health Education;Community Outreach;community partnership;Country;County;Disparity;Disparity population;Doctor of Philosophy;Education and Outreach;Elderly;Environmental Exposure;experience;Fostering;Foundations;frontier;Funding;Future;gastrointestinal;Genitourinary system;Goals;Grant;health assessment;Health Sciences;Health Services;Health Services Accessibility;Hispanic;Hispanic Populations;innovation;Institution;Knowledge;Lead;Leadership;Link;Logic;Lung;Malignant Neoplasms;Measurable;Medical;meetings;Melanoma;member;Mexico;Minority;Modeling;Monitor;NCI Center for Cancer Research;outreach;patient population;Persons;Policies;policy recommendation;Population;population health;Population Heterogeneity;programs;Recording of previous events;recruit;Research;retiree;Rural;Screening for cancer;Skin Cancer;Strategic Planning;synergism;tool;tribal Nation;Underrepresented Minority;Universities;virtual;Voice;Walking;Work

PROJECT_TITLE: Community Outreach and Engagement (COE)


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Endocannabinoid System Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: PROJECT NARRATIVE Identifying factors that contribute to risk or resilience for long-term post-traumatic distress is a pressing public health problem, particularly for urban racial minorities who are at high risk and experience significant chronic socioenvironmental stress. This work seeks to identify whether dysregulation in emotion regulation neural circuitry two weeks following trauma predicts PTSD and other post-trauma symptom twelve months later among urban Black adults. Moreover, we will examine how environmental risk (e.g., discrimination) and protective factors (e.g., neighborhood cohesino) in the months following trauma impact neurobiological stress systems and how this interplay impacts neural health and risk for chronic distress. These data will advance our understanding of both socioenvironmental and neurobiological factors associated with vulnerability to specific trauma-related pathology and provide an important step toward identifying appropriate early interventions in the wake of trauma.

PI_NAMEs: DEROON-CASSINI, TERRI A.;LARSON, CHRISTINE L (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Accident and Emergency department;Acute;Adult;adverse outcome;Affect;African American;allostatic load;Amygdaloid structure;Anxiety;Arousal;Behavioral;Biological;biological adaptation to stress;Biological Markers;Black American;Black race;Brain;brain health;Child Abuse and Neglect;Chronic;Chronic Post Traumatic Stress Disorder;community advisory board;community violence;Complement;culturally appropriate intervention;cytokine;Data;deprivation;Disadvantaged;Discrimination;Distress;Early identification;Early Intervention;emotion regulation;Endocannabinoids;Environmental Risk Factor;ethnic minority;ethnic minority population;Event;experience;Exposure to;Goals;Health;high risk;Hospitals;Image;improved;indexing;Individual;Inflammatory;innovation;intersectionality;Intervention;Knowledge;Light;Link;Machine Learning;Measures;medical schools;Mental Depression;Mental disorders;Mental Health;minority stress;Nature;Neighborhoods;neural;neural circuit;neurobehavioral;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Outcome;Pathology;Patient Self-Report;pediatric trauma;physical conditioning;Play;Population;post-trauma;Post-Traumatic Stress Disorders;Predictive Factor;predictive marker;preventive intervention;Process;Prognosis;protective factors;Public Health;Quality of life;Race;racial minority;racial minority population;Recording of previous events;Recovery;recruit;Regulation;Research;resilience;resilience factor;Resources;Risk;Risk Factors;Risk Marker;risk prediction;Role;Sampling;Sensitivity and Specificity;Social Environment;socioenvironmental factor;Specific qualifier value;Stress;stress management;stressor;suicidal risk;Survivors;Symptoms;System;Trauma;trauma exposure;trauma symptom;United States;urban setting;violence exposure;Visit;Wisconsin;Work

PROJECT_TITLE: Risk and Resilience in Urban Black American Acute Trauma Survivors

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


PROJECT_TERMS: Arizona;Award;Biomedical Engineering;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer imaging;Catchment Area;Clinical;Clinical Trials;County;Development;Disease;Ensure;Environment;Fostering;Funding;Future;gastrointestinal;Genitourinary system;Goals;Hepatobiliary;high reward;high risk;Image;interdisciplinary collaboration;Interventional Imaging;investigator-initiated trial;Investments;Lung;Malignant Neoplasms;Melanoma;member;Mission;novel;novel therapeutic intervention;Peer Review;Philanthropic Fund;Pilot Projects;Population;preventive intervention;Process;Publications;Research;Research Personnel;Strategic Planning;tool;Universities

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Pediatric;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Recent population-based studies established that teen drivers with ADHD have 30%−40% higher risk of being involved in a motor vehicle crash—the leading cause of death for US teens. This project is designed to identify the specific factors—both within and outside the immediate vehicle environment—that explain why crash risk is elevated for teen drivers with ADHD. The knowledge generated from this project will lead to the development of interventions and programs for teens with ADHD that aim to optimize their safety as independent drivers.

PI_NAMEs: CURRY, ALLISON ELIZABETH (contact);KLAUER, SHEILA

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Accelerometer;Address;Adolescence;Adolescent;adverse outcome;aged;Alcohol consumption;Attention deficit hyperactivity disorder;Automobile Driving;Behavior;behavioral outcome;Cause of Death;Cellular Phone;Childhood;cohort;Complement;Data;data warehouse;design;Disease;Disruptive Behavior Disorder;Distal;driving behavior;driving performance;driving safety;Ecological momentary assessment;Economics;Environment;Event;evidence base;Executive Dysfunction;executive function;Eye;Family;Foundations;Goals;high risk;Impairment;Individual;innovation;Intervention;kinematics;Knowledge;Learning;Licensing;Licensure;Link;Longitudinal Studies;Measurement;Measures;Methods;Modernization;modifiable risk;Monitor;Outcome;Parents;Participant;Patient Self-Report;Pattern;Performance;Persons;Pharmaceutical Preparations;Phase;Policies;Population Study;Prevalence;programs;Prospective, cohort study;Records;recruit;Research;Research Design;Resources;Risk;Risk Factors;risky driving;Safety;Seat Belts;skills;social;Societies;Speed;Stimulant;Subgroup;Surveys;System;Technology;teen drivers;Teenagers;Text;therapy development;Time;unsafe driving;Vehicle crash;Work;Young driver

PROJECT_TITLE: Longitudinal study of adverse driving outcomes among adolescents with ADHD

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Affect;anti-cancer research;Appointment;Area;Arizona;Autoimmunity;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer research center director;cancer risk;Caregivers;Caring;Catchment Area;Cellular biology;Clinical Research;Collaborations;college;Communities;community advisory board;community engagement;Community Outreach;convict;County;Dimensions;disparity elimination;diversity and inclusion;DNA Biochemistry;DNA Repair;Doctor of Philosophy;Endowment;Evaluation;Family;Female;fighting;Fostering;Funding;Generations;Genetic;Goals;Health;Health Personnel;Health Professional;improved;Inequity;innovation;Institution;interdisciplinary collaboration;International;Leadership;Malignant Neoplasms;Measures;Medical center;meetings;member;Mission;Modification;Molecular Medicine;Monitor;NCI-Designated Cancer Center;Outcome;Patients;Population;Process;professor;programs;Provider;Research;Research Personnel;Resource Sharing;Role;Science;Scientist;Secure;social;Source;Strategic Planning;Strategic vision;success;Talents;timeline;Training;Training and Education;Trust;Universities;Vision;Vulnerable Populations

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention

PI_NAMEs: HSU, CHARLES C (contact)

PROJECT_TERMS: Age;Arizona;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Communication;community engagement;Community Outreach;community partners;Conduct Clinical Trials;COVID-19 pandemic;Data;data integrity;data management;Data Management Resources;Development;Enrollment;Ensure;ethnic minority;Faculty;Female;frontier;Future;Good Clinical Practice;Hispanic;human old age (65+);improved;Individual;Industry;Information Management;Infrastructure;Institution;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;Leadership;Life Cycle Stages;life span;Malignant Neoplasms;member;Minority;Minority Participation;Monitor;National Clinical Trials Network;Nursing Research;Participant;patient safety;Peer Review;Performance;Policies;process improvement;Progress Reports;Protocols documentation;quality assurance;racial minority;real time monitoring;recruit;Reporting;Research;Research Personnel;Risk;risk minimization;Safety;Serious Adverse Event;Services;Strategic Planning;Suspensions;System;Technology;Training;Training and Education;treatment trial;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management (CPDM)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative Training in the successful completion of cutting edge biomedical cancer research, combined with engendering a deep appreciation for clinical aspects of cancer, are necessary to train the future leaders in cancer research in the United States.

PI_NAMEs: GARDINI, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Basic Cancer Research;Training Programs

PROJECT_TITLE: Training Program in Basic Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Cancer affects all populations; certain groups, including those in rural communities, are more at risk than others.[1, 2] Rural patients face disadvantages in accessing specialty care and cite geographic barriers as a frequent reason for not enrolling in studies.[5] The University of Kansas Cancer Center – Midwest Cancer Alliance Rural NCORP (KUCC-MCA Rural NCORP) will decrease barriers, expand access to trials, and enhance infrastructure in the local rural community.

PI_NAMEs: DOOLITTLE, GARY C. (contact);SHARMA, PRIYANKA

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: access disparities;Address;Affect;Area;base;cancer care;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;Cancer health equity;cancer prevention;care delivery;Caring;Clinical Research;Clinical Trials;Communities;Community Clinical Oncology Program;data quality;Diagnosis;Disadvantaged;Disparity;experience;Face;Funding;geographic barrier;Geography;Goals;Health;Health Personnel;Healthcare;high standard;Home;Hospitals;Human;human old age (65+);human subject protection;Infrastructure;Institution;Insurance Coverage;Kansas;Leadership;Localized Malignant Neoplasm;Low income;low socioeconomic status;Malignant Neoplasms;medical specialties;member;Midwestern United States;Minority;Missouri;Oncology;outreach;patient-level barriers;Patients;Population;Population Group;Positioning Attribute;practice-based research network;Prevention;Prevention Research;Primary Care;primary care practice;primary care provider;primary care setting;Process;Productivity;programs;Provider;racial minority;Recording of previous events;Research;Research Personnel;Risk;Risk Factors;Running;Rural;rural area;Rural Community;rural dwellers;rural healthcare;rural patients;Rural Population;rural setting;Site;Southwest Oncology Group;Structure;Subgroup;suburb;Telemedicine;Training;underserved community;Universities;urban area;weight loss intervention

PROJECT_TITLE: The University of Kansas Cancer Center's- MCA Rural NCORP


PI_NAMEs: GELMANN, EDWARD P (contact)

PROJECT_TERMS: anti-cancer research;Arizona;authority;Cancer Center;Cancer Center Support Grant;cancer prevention;Clinical Research;Data;data integrity;Disease;Ensure;expedited review;Feasibility Studies;Feedback;Goals;human subject;Malignant Neoplasms;Mission;Monitor;multidisciplinary;National Cancer Institute;NCI Center for Cancer Research;Oncologist;Outcome Study;Peer Review;Population;Process;Protocols documentation;Recommendation;Research;research study;Review Committee;Risk;Safety;Scientist;sound;Specialist;Structure;System;therapeutic development;Universities

PROJECT_TITLE: Protocol Review and Monitoring System (PRMS)


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: CHOW, H-H. SHERRY (contact)

PROJECT_TERMS: Advisory Committees;Analytical Chemistry;Applications Grants;Arizona;Basic Science;bioactive food component;Biochemistry;Biological;Biological Assay;Biological Availability;Biological Markers;Biometry;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer initiation;cancer prevention;cancer risk;cancer therapy;Carcinogen exposure;carcinogenesis;Carcinogens;Chemistry;Chemoprevention;Clinical Research;Clinical Trials;Collaborations;Computer software;Consultations;cost effective;Data;Data Analyses;design;Development;Disease Progression;Doctor of Philosophy;Drug Kinetics;Drug or chemical Tissue Distribution;Education;Elements;Ensure;Environmental Risk Factor;experience;Funding;Goals;Grant;Hour;innovation;instrument;instrumentation;Knowledge;lifestyle factors;lipidomics;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Medicine;member;Metabolic;metabolomics;method development;Methodology;Methods;novel;novel therapeutic intervention;Nutrient;Nutritional Science;Pharmacodynamics;population based;Preclinical Drug Development;preclinical evaluation;Preparation;Preventive;preventive intervention;Productivity;professor;programs;Protocols documentation;Publications;recruit;repository;Research;Research Assistant;research clinical testing;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Sampling;Services;small molecule;Specimen;Surveys;Therapeutic;Therapeutic Intervention;timeline;Tissues;Training;Translational Research;Universities;Work

PROJECT_TITLE: Analytical Chemistry Shared Resource (ACSR)


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Our long-term goal is to understand how cell death takes place during normal animal development and disease. We uncovered a novel cell death process in the nematode C. elegans with similarities to normal and disease-related cell death in humans, and aim to understand the details of this novel killing mechanism. Our studies may, therefore, provide in-roads towards understanding and, perhaps, treatment of degenerative human diseases.

PI_NAMEs: SHAHAM, SHAI  (contact)

PROJECT_TERMS: Adult;Animals;Apoptosis;Apoptotic;apoptotic protease-activating factor 1;Autophagocytosis;axonal degeneration;Axotomy;Binding;biological adaptation to stress;Caenorhabditis elegans;CASP3 gene;CASP9 gene;Caspase;Cell Death;Cell Death Process;Cell Nucleus;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Characteristics;Chromatin;chromatin modification;Complex;Cullin Proteins;Cytoplasm;Cytoplasmic Organelle;demethylation;Development;Disease;Distal;DNA;DNA Methylation;Enzymes;gene induction;Genes;Genetic;Genetic study;genome-wide;Glutamine;Goals;heat shock transcription factor;Heat-Shock Response;histone methylation;Histones;Homologous Gene;Human;human disease;Incubated;kinase inhibitor;Mammalian Cell;Mammals;Mediating;methionine adenosyltransferase;Methyltransferase;Mitogen-Activated Protein Kinase Kinases;Modeling;Molecular;Molecular Genetics;morphological criteria;Morphology;mouse development;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Necrosis;Nematoda;Nerve Degeneration;novel;Nuclear;nuclease;Pathway interactions;Patients;Peptide Hydrolases;Physical condensation;Play;polyglutamine;Prevalence;Process;programs;Proteins;Regulation;Role;Staurosporine;Swelling;System;Tertiary Protein Structure;Testing;tool;transcription factor;UBE2D2 gene;Ubiquitin;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Vertebrates;WNT Signaling Pathway

PROJECT_TITLE: Linker cell death regulation in C. elegans

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Prevention;Rural Health;Telehealth

PROJECT_TERMS: actigraphy;Address;Alcohol consumption;American Indians;anti-cancer research;Applications Grants;Area;Arizona;Automobile Driving;Behavior;Behavior assessment;behavior measurement;Behavior Therapy;Behavioral;Behavioral Research;Body Composition;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer prevention;Catchment Area;comorbidity;Comprehensive Cancer Center;Computer software;Consultations;Continuity of Patient Care;Data;Development;Diet;digital health;digital technology;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Education;eHealth;Electronic Mail;Ensure;Equipment;evidence base;Food;frontier;Future;Goals;graduate student;Health;health assessment;Health behavior;Health Promotion Sciences;high standard;Hispanic Populations;Human Resources;Incidence;innovation;instrument;Intervention;Intervention Studies;investigator training;Life Style;Malignant Neoplasms;Measurement;Measures;member;Methods;mHealth;mid-career faculty;multimodality;National Cancer Institute;next generation;Obesity;Outcome;Output;Peer Review;Physical activity;population health;professor;programs;Publications;Quality Control;Quality of life;Questionnaires;Recurrence;Research;Research Assistant;Research Design;Research Methodology;Research Personnel;Research Training;Resource Sharing;Resources;Risk Factors;Rural;Scientist;Screening for cancer;Services;Sleep;Source;Students;Survivors;symptom management;System;Technology;Telephone;Text Messaging;Tobacco use;Training;Training and Education;undergraduate research;Universities;UV Radiation Exposure;Vaccination;Work

PROJECT_TITLE: Behavioral Measurement and Interventions Shared Resource (BMISR)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PI_NAMEs: ROE, DENISE J (contact)

PROJECT_TERMS: Address;Algorithm Design;algorithm development;Animals;anti-cancer research;Applications Grants;Arizona;Artificial Intelligence;Bioinformatics;Bioinformatics Shared Resource;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer genomics;Clinical;Clinical Cancer Center;Clinical Investigator;Clinical Protocols;Clinical Research;clinical training;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Cluster randomized trial;Collaborations;Collection;Computer software;Conceptions;cost effective;Data;Data Analyses;data integration;data integrity;data management;data modeling;Data Science;design;Doctor of Philosophy;Education;Educational workshop;Ensure;experience;Faculty;Funding;Genetic;Genomics;Goals;Human Resources;Individual;innovation;Institution;investigator-initiated trial;Laboratory Research;Machine Learning;Manuscripts;member;Mentors;Monitor;multidimensional data;Multiomic Data;NCI Center for Cancer Research;next generation;novel;Pathway Analysis;Patient Outcomes Assessments;Peer Review;Population Research;Preparation;programs;protocol development;Protocols documentation;Public Health Schools;Publications;Qualifying;recruit;Reporting;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Review Committee;safety study;Sample Size;Services;Statistical Computing;Statistical Data Interpretation;Structure;Students;Survival Analysis;Techniques;Training;Training and Education;Translational Research;Translations;Universities

PROJECT_TITLE: Biostatistics and Bioinformatics Shared Resource (BBSR)


ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE STATEMENT: Cancer immunotherapy is revolutionizing the treatment of cancer, however, less than half of patients treated with immunotherapy experience a response or long-term remission. Recent discoveries suggest that the outcomes from cancer immunotherapies depend on complex interactions among the tumor, host immune system and microbiome. The complexity of this interaction presents a challenging task and a huge unmet need in the education of cancer researchers, because research in this area requires synthesis across multiple disciplines: cancer biology, immunology, microbiology, statistics and bioinformatics. This proposal fills a gap in the education of the cancer researcher and will help train a work force with the knowledge and skills needed to advance interdisciplinary research in cancer immunotherapy.

PI_NAMEs: CHAN, CLIBURN C;GRANEK, JOSHUA AARON;OWZAR, KOUROS  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;anti-cancer research;Area;Bioinformatics;bioinformatics pipeline;Biological Assay;Biology;Cancer Biology;cancer education;cancer genomics;cancer immunotherapy;cancer therapy;Communities;Complex;complex data;Coupled;Data;data integration;Data Set;design;Discipline;Disease remission;Education;Educational Materials;Educational process of instructing;Elements;experience;Experimental Designs;experimental study;Faculty;Future;graduate student;high throughput analysis;High-Throughput Nucleotide Sequencing;human data;Immune system;Immunology;Immunophenotyping;Immunotherapy;improved;Institution;Interdisciplinary Study;interest;Knowledge;Learning;learning materials;learning outcome;Malignant Neoplasms;Methodology;Methods;microbial community;Microbiology;microbiome;microbiome analysis;microbiome sequencing;Modernization;Mus;online resource;Outcome;Participant;patient engagement;Patients;Postdoctoral Fellow;Process;Productivity;Reproducibility;Research;Research Personnel;research study;response;satisfaction;Scientist;Series;single-cell RNA sequencing;skills;Statistical Methods;statistics;Structure;Students;T-cell receptor repertoire;technological innovation;Technology;Time;tool;Training;Training Programs;tumor;tumor immunology;Work

PROJECT_TITLE: Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: WARFEL, NOEL ANDREW (contact)

PROJECT_TERMS: Animals;anti-cancer research;Applications Grants;Arizona;Breeding;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Model;cancer prevention;Clinical Oncology;Consult;Consultations;cost;Cryopreservation;Derivation procedure;design;Development;Doctor of Philosophy;drug testing;Education;Embryo;embryo cryopreservation;Ensure;Equipment;Fertilization in Vitro;Funding;Generations;Genetic;Genetic Engineering;Genetic Models for Cancer;Genetically Engineered Mouse;Genotype;Goals;good laboratory practice;IACUC;Immunocompromised Host;Immunodeficient Mouse;improved;in vivo;in vivo Model;Injections;innovation;Intervention;Maintenance;Malignant Neoplasms;Measures;member;Methods;Modeling;Modification;Mouse Strains;Mus;Neoplasm Metastasis;neoplastic cell;novel anticancer drug;Operative Surgical Procedures;Organ;Pathologic;patient derived xenograft model;Peer Review;Primary Neoplasm;Production;Productivity;programs;Protocols documentation;Publications;Qualifying;Quality Control;Rattus;Reproducibility;Research;research and development;Research Design;Research Personnel;Resource Sharing;response;Rodent;Rodent Model;Scheme;Secure;Services;Solid Neoplasm;sperm cryopreservation;Students;Surgical complication;Techniques;Testing;tissue preparation;tissue processing;Tissues;Training;translational oncology;treatment response;tumor;tumorigenesis;Universities;vector;Work;Xenograft procedure

PROJECT_TITLE: Experimental Mouse Shared Resource (EMSR)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Addictions are arguably the most costly conditions to society. Thus, investigations into new and improved treatments for addictions are of vital importance. This proposal seeks support to train early career investigators at the junior faculty level for training as clinician scientists investigating drug addiction, with a focus on treatment development.

PI_NAMEs: O'MALLEY, STEPHANIE S;POTENZA, MARC N (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: addiction;Behavior Therapy;career;clinical investigation;Clinical Research;clinical training;Development;Drug abuse;Drug Addiction;early-career faculty;Evaluation;Exploratory/Developmental Grant;Faculty;Funding;Generations;Goals;Health Services Research;Individual;innovation;interest;Learning;medical schools;member;Mentorship;Molecular Neurobiology;multidisciplinary;Pharmacological Treatment;Phase;pre-clinical;programs;Psychiatry;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Scientist;skills;Substance abuse problem;therapy development;Training;Training Programs;Translational Research;virtual;Work

PROJECT_TITLE: Clinician Scientist Training Program (CSTP)