NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Resident memory CD8 T cells (TRM) are crucial to the immune defense of the mucosal organs. However local mucosa signals that mediate TRM differentiation, function as well as their long-term maintenance are largely unexplored. This proposal aims to use a novel 3D vaginal epithelial organoid-CD8 T cell coculture system to interrogate the molecular nature of this epithelium-T cell interaction necessary for successful TRM differentiation.

PI_NAMEs: BEURA, LALIT K (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;antiviral immunity;Architecture;Automobile Driving;Biological Models;Biology;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Count;Cells;Cellular biology;Chemicals;Coculture Techniques;Communication;Complex;Cues;density;differentiation in vitro;Environment;Epithelial Cells;Epithelium;experimental study;female reproductive tract;female reproductive tract infection;Flow Cytometry;Gene Expression Profiling;Genetic;Genetic Screening;Genetic Transcription;Glean;Goals;Hand;high dimensionality;Human Herpesvirus 2;Immune;Immunologic Surveillance;improved;In Vitro;in vivo;Incubated;Infection;innovation;insight;Intrinsic factor;Investigation;Kinetics;Longevity;Maintenance;Mediating;Memory;Methods;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Nature;novel;Organ;Organoids;overexpression;pathogen;Pathogenicity;Pathway interactions;Phenotype;Positioning Attribute;Process;programs;reproductive;Retinoic Acid Receptor;RNA interference screen;Rodent Model;Role;RUNX3 gene;Sampling Biases;Shapes;Signal Transduction;Source;Specific qualifier value;Stratified Squamous Epithelium;Study models;System;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;transcription factor;Tretinoin;Vagina;vaginal mucosa;Viral;virtual;Virus Diseases;Women's Role;Work

PROJECT_TITLE: Interrogating mucosal resident memory CD8 T cell biology with 3D organoids

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative We hypothesize that generating consensus on the spectrum of clinical phenotypes of status epilepticus (SE) and building an NLP-based tool, using both structured and unstructured EHR data, to identify and classify SE is essential for the creation of SE registries, needed to conduct future comparative effectiveness and pragmatic trials of SE treatment. In Aim 1, we will apply an innovative sequential mixed methods approach, using (a) a modified Delphi method to establish consensus around labels to identify relevant information elements and (b) a discrete choice experiment method to identify time-evolving attributes of progression to RSE. In Aim 2, we will leverage unstructured EHR data from two large academic centers to fine-tune and apply multiple NLP- based machine-learning models, including Large Language Models, and compare their performance in identifying and extracting cases of SE and RSE.

PI_NAMEs: HAIDER, HIBA A (contact);ZAFAR, SAHAR F

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute myocardial infarction;acute stroke;Admission activity;Affect;appropriate dose;Brain;Caring;Categories;Cessation of life;Classification;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinical development;clinical heterogeneity;clinical phenotype;Code;Collaborations;comparative effectiveness study;comparative effectiveness trial;comparative trial;Complex;computerized data processing;Consensus;cost;Critical Care;Data;Data Scientist;data standards;Death Rate;Detection;Deterioration;Diagnosis;Diagnostic;Dimensions;Disability status;Early Diagnosis;early experience;effectiveness trial;Electroencephalography;Electronic Health Record;electronic structure;Elements;Emergency Situation;Epidemiology;Epilepsy;experimental study;Foundations;Future;high risk;high risk population;hospital readmission;Hospitalization;improved;Incidence;indexing;Individual;innovation;Inpatients;Instruction;Knowledge;Label;large language model;Length of Stay;Machine Learning;machine learning model;Measures;Methodology;Methods;Modeling;mortality;Natural History;Natural Language Processing;Neurologic;Neurological emergencies;Neurology;Neuronal Injury;Outcome;Patients;Performance;Persons;Pharmaceutical Preparations;Phenotype;Population;population based;pragmatic trial;predictive modeling;prevent;Prevention;Preventive;randomized trial;Refractory;Registries;Research Personnel;Resources;Risk;Seizures;Source;Status Epilepticus;Structure;structured data;support tools;Symptoms;targeted treatment;Text;Time;tool;United States;unstructured data

PROJECT_TITLE: Mixed Methods Framework to Facilitate Clinical Phenotyping and Surveillance of Status Epilepticus

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: NARRATIVE Our ability to develop effective therapeutics to treat human diseases is greatly aided by structural descriptions of macromolecules. However, preserving these isolated targets for structural study with one of the most popular methods for structure determination, cryo-electron microscopy, is a major bottleneck in our ability to understand the mechanisms underlying disease. This proposal aims to overhaul our approach to cryo-electron microscopy structure determination in order to overcome this bottleneck, ushering in a new era of structural biology.

PI_NAMEs: LANDER, GABRIEL C (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Developing graphene grids to overcome air-water-interface issues

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SAINT LOUIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The current proposal aims to examine the changes in the synaptic transcriptome of the primary- secondary sensory afferents structure occurring in the spinal cord during synaptic gain of function in neuropathic pain. Completion of this work will yield a comprehensive map of the transcriptomic changes that occur in the synapse during neuropathic pain and examine the factors that contribute to this highly polarized transcriptomic population. Targeting of those factors will yield new therapeutic avenues for neuropathic pain.

PI_NAMEs: FRANCOIS EP MOUTAL, LIBERTY  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Address;Affect;Afferent Neurons;Axon;beta Actin;Binding;Biological;Calcium Channel;Chronic;chronic neuropathic pain;chronic pain;cis acting element;Complex;Contralateral;Cytoplasmic Granules;Cytoskeleton;Data;Defect;Dendrites;Development;differential expression;Elements;Erinaceidae;Event;experimental study;G-Quartets;gain of function;Gene Expression;Genes;Guanine;Harvest;Hypersensitivity;Immunoprecipitation;in vivo;innovation;Insulin-Like Growth Factor II;Ipsilateral;Kinesin;Link;male;Maps;Mediating;Membrane;Messenger RNA;Metabolic;Metabotropic Glutamate Receptors;Modeling;Modification;Molecular;Motor;nerve injury;Neurites;Neurodegenerative Disorders;neuronal transport;Neurons;neuroprotection;Nociception;Nociceptors;novel therapeutics;Operative Surgical Procedures;Organelles;Outcome Study;Pain;painful neuropathy;Painless;Pathologic;Pattern;Peptides;Phase;Play;Population;Porifera;Proteins;Rattus;Reproducibility;Research;response;RNA;RNA Transport;RNA-Binding Proteins;Role;Sensory;sex;Side;Signal Transduction;Sodium Channel;spared nerve;Spinal Cord;Spinal cord posterior horn;Spinal nerve structure;Stimulus;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptosomes;Tactile;Testing;Therapeutic;Time;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;Work

PROJECT_TITLE: Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative  Brucella spp. are bacteria that cause a debilitating, flu-like disease in humans, and these bacteria are classified as Select Agents due to their potential use as biological weapons. Currently, no safe and effective vaccine exists to protect against human Brucella infection. The proposed research will define a novel small regulatory RNA pathway in Brucella that may be targeted for vaccine and/or therapeutic development.

PI_NAMEs: CASWELL, CLAYTON C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: abortion;Anabolism;Animal Model;Animals;Antibiotic Therapy;Antibiotics;attenuation;Bacteria;bacteria classification;Binding Sites;Biological Assay;Biology;bioweapon;Brucella;Brucella abortus;Brucellosis;Cell model;Cells;Chronic;combat;Critical Pathways;Cytoplasm;Data;Defect;deletion analysis;Development;Disease;Domestic Animals;Enzymes;experimental study;exposed human population;Exposure to;flu;Future;Gene Deletion;Genes;Genetic;Glean;Goals;Growth;Human;Immune;In Vitro;in vivo;Infection;Kinetics;Laboratories;Macrophage;Mediating;Messenger RNA;Modeling;mouse model;Mus;Mutation Analysis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;novel vaccines;Nucleotides;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptidoglycan;Phenotype;Physiological;Production;programs;Proteins;Recurrent disease;Regulatory Pathway;Relapse;Repression;Research;Ribosomes;RNA;RNA Binding;Small RNA;Sterility;System;Testing;Therapeutic;therapeutic development;Translational Repression;Translations;Treatment Protocols;vaccine development;vaccine strategy;Vaccines;Virulence;Wild Animals;Work

PROJECT_TITLE: Elucidating the regulatory mechanism of a Brucella-specific small RNA required for virulence

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Physical Activity

ORG_CITY: OXFORD

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: Project Narrative This project is relevant to public health because the detrimental effects of physical inactivity (PIA) during the initial years of life on adult health are vastly undervalued and unknown. Early life PIA during a key period of development may result in reduced muscle quality and function such that an adult who experiences early life PIA would have the muscular function and physical capacity equivalent to someone many years their senior – premature aging. This work would stress the importance of avoiding early-life PIA to minimize healthcare costs associated with losing physical function and quality of life with earlier development of frailty.

PI_NAMEs: REIDY, PAUL TIMOTHY (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;active control;Address;Adult;Age;age acceleration;Aging;aging process;Area;Attenuated;Biomedical Research;Body System;bone;career;career development;Child;Childhood;Chronic Disease;clinical practice;Collagen;Collection;comparison control;critical period;Data;Data Analyses;Development;disorder risk;early experience;emerging adult;Epidemic;Equation;Equilibrium;experience;experimental study;Exposure to;Extracellular Matrix;Female;frailty;functional decline;Gene Expression;graduate student;Growth;Hand Strength;Health;Health Care Costs;Hindlimb Suspension;Human;Immunofluorescence Immunologic;Impairment;in vivo evaluation;Influentials;innovation;Investigation;Knowledge;Laboratories;Life;Life Cycle Stages;life span;Link;Longevity;loss of function;Macrophage;male;Malnutrition;Measures;Medicine;Mentors;Metabolic;Metabolic dysfunction;Metabolism;Methods;middle age;Modeling;mortality;Mus;Muscle;Muscle Development;Muscle function;Muscular Atrophy;neuromuscular;neuromuscular function;novel;old mice;pandemic disease;performance tests;Phenotype;Physical activity;Physical Capacity;Physical Function;physical inactivity;Physical Performance;Population;postnatal;postnatal development;postnatal period;premature;Premature aging syndrome;Premature Mortality;Production;programs;Public Health;Quality of life;reduced muscle mass;reduced muscle strength;Regulation;research data dissemination;Research Methodology;Research Personnel;Rodent;Running;sarcopenia;sedentary;Severities;Skeletal Muscle;skeletal muscle wasting;Stress;Structure;Students;Techniques;Testing;Tissues;Training;Translational Research;undergraduate student;Universities;Weaning;Weight;Work;Youth

PROJECT_TITLE: Influence of early life physical inactivity during a key period of postnatal development on adult muscle quality – from matrix to mortality

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-Q (80)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Despite recent associations with γδ T cell infiltration and better outcome in different human tumors, the immunobiology of this T cell subset, and its potential as a platform for immunotherapies against cancer, remains elusive. The studies proposed in this application have the potential to exert a profound effect in the field of cancer immunotherapy by demonstrating that a subset of γδ T cells, which is more resilient to loss of effector activity at solid tumor beds, is a superior platform for novel Car T cell therapies against tumors that have so far remain stubbornly refractory to cellular therapies. The insight derived from these studies will provide a mechanistic rationale for novel clinical trials, designed to overcome the hitherto insurmountable challenge of controlling epithelial malignancies using cellular therapies, thus advancing towards the cure of one of the most devastating malignancies.

PI_NAMEs: CONEJO-GARCIA, JOSE R (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Address;Adipose tissue;Agonist;Allogenic;Autologous;Beds;Binding;butyrophilin;cancer immunotherapy;CAR T cell therapy;Carcinoma;CD8-Positive T-Lymphocytes;CD94 Antigen;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical Trials;combat;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;design;Down-Regulation;Effectiveness;effector T cell;Epithelium;Evolution;exhaustion;experimental study;Extended Family;Family;Fatty Acids;Funding;Grant;Heterogeneity;Human;IL7R gene;Immunobiology;Immunotherapeutic agent;Immunotherapy;in vivo;infancy;Infiltration;insight;Interleukin-2;Knowledge;Lipids;Lymphocyte;Lymphoma;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;member;Membrane Glycoproteins;Metabolic;Molecular;mouse model;Mus;neoplastic cell;novel;Outcome;Peripheral;Phenotype;pressure;Production;programmed cell death protein 1;Recombinants;Refractory;Repression;resilience;response;Role;RUNX3 gene;Signal Transduction;Solid;Solid Neoplasm;stemness;T cell infiltration;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;TCR Activation;Testing;Thermogenesis;transcription factor;Transgenic Model;tumor;Tumor Immunity;Tumor-Infiltrating Lymphocytes;Umbilical Cord Blood;γδ T cells

PROJECT_TITLE: Crosstalk between butyrophilins and gamma delta T cells in human cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative As first-generation, low-income, and racial/ethnic minority students have improved their access to higher education, nutrition insecurity in US campuses has increased and threatens their academic success and well- being. College food pantries have been the most common solution but only offer short-term emergency relief, and stigma has prevented their use. To provide a longer-term evidence-based approach that honors students' choices and dignity, this research will inform the development of an adaptable campus mobile market model that consistently provides access to healthy food and promotes healthy eating.

PI_NAMEs: LEONE, LUCIA A (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Address;Behavior;Cluster randomized trial;college;Consumption;cooking;design;Development;Diabetes Mellitus;Diet;dietary;Discrimination;Disease;Disparity;dosage;Education;effectiveness research;efficacy research;Eligibility Determination;Emergency Situation;Enrollment;Environment;Equity;ethnic minority;Evaluation;evidence base;Exclusion;experience;Face;First Generation College Students;Focus Groups;Food;Food Access;food insecurity;Fright;fruits and vegetables;Future;Generations;Goals;Graduation Rates;Health;health disparity;Health Food;Health Promotion;Healthy Eating;High School Student;higher education;Hour;Household;Hunger;Hyperlipidemia;Hypertension;implementation research;implementation science;improved;Individual;Inferior;innovation;Institution;Intake;Intervention;Interview;Judgment;Location;Low income;Marketing;Mental Depression;Mental Health;Methods;minority student;Modeling;Monitor;Needs Assessment;New York;nutrition;Nutrition Assessment;Nutritional;Outcome;Pattern;Performance;Personal Satisfaction;physical conditioning;pilot test;Population;pre-pandemic;Pre-Post Tests;prevent;Price;programs;Quasi-experiment;racial minority;Recommendation;Reporting;Research;retention rate;Security;Series;Shame;social stigma;Structure;Students;success;Surveys;symposium;System;Testing;Training;underserved community;United States;Universities;university student;Weight Gain;work-study

PROJECT_TITLE: Adapting the Veggie Van mobile market intervention to address disparities in nutrition security among college students

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative This R03 proposal addresses a critical public health need by identifying and validating an objective, efficient, and sensitive metric for tracking social communication outcomes in a particularly vulnerable population – autistic adolescents transitioning to adulthood. To achieve this goal, we will employ cutting-edge computational linguistics techniques to analyze the precise ways in which a person’s social conversation skills improve over time as they participate in a long-term, comprehensive intervention program to learn new social communication skills. This proposal has high public health relevance because it aims to identify specific speech and language markers that will allow us to customize and optimize treatment efforts to match the unique needs of each adolescent on the autism spectrum and then rapidly, objectively, and comprehensively evaluate their ongoing response to intervention.

PI_NAMEs: PARISH-MORRIS, JULIA ;VERNON, TY WESTON (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;adolescent with autism spectrum disorder;aged;Anxiety;autism spectrum disorder;autistic;biomarker identification;Clinical;clinical care;clinical outcome measures;clinical practice;clinical predictors;Clinical Trials;cohort;Collection;Computational Linguistics;Computing Methodologies;Confusion;Consumption;Data;Data Set;design;Development;Diagnosis;Dimensions;Employment;Female;follow-up;Foundations;Friends;Funding;Future;Goals;group intervention;Growth;Heterogeneity;Human;implementation intervention;impression;improved;Individual;individuals with autism spectrum disorder;innovation;insight;Intake;interest;Intervention;intervention program;Knowledge;Language;Learning;Linguistics;longitudinal dataset;Love;male;Measures;Mental Depression;Modeling;Monitor;National Institute on Deafness and Other Communication Disorders;Outcome;Outcome Assessment;Outcome Measure;Output;Parents;Participant;Patient Self-Report;Pattern;personalized approach;personalized intervention;Persons;Phenotype;Pilot Projects;post intervention;precision medicine;predictive marker;Prevention approach;Process;prospective;Protocols documentation;Public Health;public health relevance;Publishing;Quality of life;Randomized, Controlled Trials;Readiness;repetitive behavior;Research;research study;response;Same-sex;Sampling;Services;sex;skills;social;social communication;social expectations;Social Interaction;social interventions;social skills;Social support;Speech;Standardization;Strategic Planning;Subgroup;success;suicidal;Techniques;Teenagers;Testing;Time;transition to adulthood;Treatment Efficacy;treatment optimization;Unemployment;Video Recording;Vulnerable Populations;Waiting Lists;Youth

PROJECT_TITLE: Computational Linguistics for Autism-related Social Skills: Assessment for Characterization and Therapy (CLASS-ACT)

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The COVID-19 pandemic has disproportionately affected African Americans (AA) and sickle cell disease (SCD), a life-threatening condition primarily affecting AA, has magnified the impact of COVID-19 in AA community. This study will identify the risk factors, both biological and social, for adverse outcomes of COVID-19 in SCD people and characterize the features of long-COVID, a serious post-COVID sequela, in SCD population. Collectively, these discoveries will help develop risk-stratified clinical pathways to prevent adverse outcomes of high-risk SCD patients.

PI_NAMEs: SHARATHKUMAR, ANJALI ALATKAR (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Acute;acute COVID-19;Address;adverse outcome;Affect;African American;African American population;Age;Algorithms;Anti-viral Agents;Anti-viral Therapy;Biological;Biosocial;Cardiovascular Diseases;Cessation of life;Characteristics;Clinical;Clinical Pathways;clinical practice;clinical risk;Cluster Analysis;Code;cohort;Cohort Studies;Communities;comorbidity;comparison group;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 sequelae;COVID-19 severity;COVID-19 surveillance;COVID-19 test;COVID-19 therapeutics;COVID-19 treatment;Data;data integration;data quality;data registry;Databases;Diagnosis;Disease;Early Intervention;Electronic Health Record;Endemic Diseases;Epidemiology;Equitable healthcare;Ethnic Origin;evidence base;Future;Gender;General Population;Geographic Locations;Goals;Health;health disparity;health equity;health management;Health Policy;Healthcare Systems;Heterogeneity;high risk;Hispanic Populations;Human;improved;indexing;Individual;individual patient;Infection;Insurance;Interdisciplinary Study;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Knowledge;Life;Long COVID;long term consequences of COVID-19;Machine Learning;machine learning method;Measures;Medical;Minority Groups;Morbidity - disease rate;mortality;Multivariate Analysis;National Institute on Minority Health and Health Disparities;novel;Ontology;Outcome;outcome disparities;pandemic disease;Patients;Persons;Phase;Phenotype;Policy Making;Population;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;Prevalence;prevent;previous pandemic;privacy preservation;Proxy;Public Health;Public Policy;Race;Records;Registries;Relative Risks;Reporting;repository;Research;Research Design;Risk;Risk Factors;Risk Reduction;risk stratification;Rural;rural area;Sample Size;SARS-CoV-2 positive;severe COVID-19;sex;Sickle Cell Anemia;social;social health determinants;social vulnerability;Statistical Methods;Strategic vision;Therapeutic;treatment stratification;trend;United States National Institutes of Health;unsupervised learning;Vaccination;Vaccines;Variant;Viral

PROJECT_TITLE: Epidemiology and Biosocial risk factors for adverse outcomes of COVID-19 in people with sickle cell disease : Analyses of national COVID surveillance registry

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project narrative The proposed research aims to develop a new specimen platform comprised of tailored, chemically modified graphene grids to enhance the efficiency of cryo-EM sample preparation. This novel technology will accelerate protein structure elucidation in biochemistry and structural biology, providing invaluable insights into understanding of diseases and biological functions.

PI_NAMEs: HE, MAGGIE  (contact)

PROJECT_TITLE: Graphene covalent grids for single-particle cryo-EM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Impaired intramembranous bone regeneration can lead to failure of orhopaedic or dental implants or delayed fracture healing. The underlying mechanisms contributing to intramembranous bone regeneration remain unclear. This project will elucidate the underlying molecular basis with important translational implications for patients that undergo orthopaedic or dental procedures.

PI_NAMEs: KO, FRANK  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;Actins;Address;Allogenic;angiogenesis;Autologous;Biomimetics;blood vessel development;Blood Vessels;bone;bone fracture repair;Bone Marrow Ablation;bone mass;Bone Regeneration;Cell Separation;Cells;Clinical;Collagen Type I;conventional therapy;Data;Defect;Dental;Dental Care;Dental Implants;Distraction Osteogenesis;Emerging Technologies;Endothelial Cells;endothelial stem cell;Endothelium;Exhibits;Failure;Future;Gene Expression;Goals;healing;Hematoma;Image;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;Implantation procedure;Inflammation;insight;Intervention Studies;intramembranous bone;Invaded;Knowledge;Label;Lead;Light;Marrow;Mesenchymal;Microscopy;Molecular;Mus;neglect;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Orthopedic Procedures;Orthopedics;osseointegrated implant;Osteoblasts;osteoprogenitor cell;Outcome;Pathway interactions;Patients;Procedures;Process;protein expression;Recovery;regeneration model;Replacement Arthroplasty;Role;Signal Pathway;Smooth Muscle;Spatial Distribution;spatiotemporal;success;Therapeutic;Thick;Time;tissue regeneration;Tissues;tomography;vasculogenesis;Vasculogenic;Western Blotting

PROJECT_TITLE: Examining endothelial cell and its plasticity in intramembranous bone regeneration

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: WILMINGTON

ORG_NAME: UNIVERSITY OF NORTH CAROLINA WILMINGTON

PHR: PROJECT NARRATIVE Development of an animal model of symbolic processes has broad relevance for public health. A successful model will permit translational research on the role of learned symbolic associations in the acquisition, maintenance and relapse of substance use and other mental health disorders. Thus, the research is relevant to NIH’s mission that emphasizes gaining knowledge to enhance health and prevent illness.

PI_NAMEs: BRUCE, KATHERINE ELY (contact);GALIZIO, JOSEPH MARK

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Animal Model;animal model development;Animals;Association Learning;Basic Science;Behavior;Categories;Columbidae;Complex;Conditioned Reflex;Cues;Desire for food;Development;Disabled Persons;Discrimination;Elements;experience;experimental study;Exposure to;Health;Human;Knowledge;Laboratories;Learning;Maintenance;Mediating;member;Memory;Mental disorders;Mission;Modeling;Morphine;novel;Odors;olfactory stimulus;Pharmaceutical Preparations;preference;prevent;Procedures;Process;Property;public health relevance;Rattus;Recording of previous events;Relapse;Research;response;Rewards;Role;Sea Lions;Semantics;Stimulus;substance use;Substance Use Disorder;substance use treatment;Testing;Training;translational potential;Translational Research;United States National Institutes of Health;verbal;Wit

PROJECT_TITLE: Transfer of function across equivalence classes: Implications for substance use

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences;Pediatric;Urologic Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Lower urinary tract (LUT) dysfunction and the conditions (i.e., disorders of urination) underlying them affect ~20% of school-aged children and >40% of adults over 40 years old, and there are known sex differences in terms of LUT condition prevalence rates and symptom score at presentation. Current understanding of the pathophysiology of sex differences in LUT dysfunction is limited by the lack of appropriate animal models in which males and females can be compared to each other. The proposed research will define sex-specific effects of chronic social defeat stress in mice on change in urination pattern, determine the impact of sex hormones on development of LUT dysfunction, and potentially lay the groundwork for a future where sex-specific assessment of treatment of LUT dysfunction is possible.

PI_NAMEs: VAN BATAVIA, JASON PHILIP (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adult;Affect;Age;Animal Model;Anxiety;Basic Science;Behavioral Assay;Birth;Bladder;Brain;Brain region;Brain Stem;bullying;Cell Nucleus;Child;Chronic;Clinical;Clinical Sciences;Collaborations;Communication;comorbidity;Corticosterone;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRF receptor type 1;Data;desensitization;Development;Diagnosis;Disease;Ensure;Estrogen Receptors;Etiology;Excision;Exposure to;Feeling;Female;Fluorescent in Situ Hybridization;Functional disorder;Future;Gonadal Hormones;Gonadal Steroid Hormones;Grant;Growth;Histology;hormonal signals;Hormones;hypothalamic-pituitary-adrenal axis;improved;Knowledge;Laboratories;Link;Lower urinary tract;lower urinary tract symptoms;male;Measures;Mental Depression;Mental disorders;Mentors;Modeling;Mus;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;Neurohormones;Neurons;Neuropeptides;neuropsychiatry;novel;Obstruction;optogenetics;Outcome;Overactive Bladder;Pattern;personalized medicine;Phenotype;Population;Predisposition;Prevalence;Prevention;Psychological Stress;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Publishing;Quality of life;receptor;receptor expression;reduce symptoms;Research;resilience;response;RNA;Rodent;Role;School-Age Population;Schools;sex;Sex Differences;sex variable;sexual dimorphism;skills;social defeat;social stress;stem;Stress;Symptoms;Testing;Urination;Urologist;Urology;Work;young adult

PROJECT_TITLE: Bladder Voiding After Stress Defeat Stress: Impact of Sex and Gonadal Hormones

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE We are proposing to carry out a 2B compounds DNA-encoded library screen with four kinase targets that are validated for contraception and cancer and that are understudied. These targets would greatly benefit from the availability of potent and selective allosteric inhibitors to probe biology and to provide chemical matter for drug discovery explorations.

PI_NAMEs: GEORG, GUNDA I. (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: Binding;Binding Sites;Biochemical;Biological Assay;Biology;Biophysics;Cancer cell line;cancer therapy;CDK2 gene;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Computer Assisted;Contraceptive Agents;Contraceptive methods;Cyclin-Dependent Kinase Inhibitor;Cyclins;Development;Disease;DNA;drug discovery;Drug Targeting;druggable target;Elements;FDA approved;Female;Female Contraceptive Agents;Goals;Grant;Immobilization;In Vitro;inhibitor;kinase inhibitor;Laboratories;Letters;Libraries;magnetic beads;male;Male Contraceptive Agents;Malignant Neoplasms;Measurement;Molecular Conformation;novel;Pharmaceutical Preparations;Pharmacologic Substance;Phosphotransferases;Property;Protein Inhibition;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Receptor Protein-Tyrosine Kinases;Research;screening;Serine;side effect;Site;sperm cell;Sperm Motility;targeted treatment;Technology;Testing;Testis;Time;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Validation

PROJECT_TITLE: DEL Screening Campaign for Contraceptive and Cancer Targets

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Asthma;Lung;Pediatric

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Creatine kinase (CK) is a protein that plays a vital role in cellular energy. Recently, we observed for the first time that blood levels of CK are decreased in childhood asthma and that children with asthma who have low CK are at increased risk of having persistence of disease into adult life. This R21 application will use data from multiple epidemiological cohorts to characterize the role of CK in blood and in the lungs in children and adults with asthma.

PI_NAMEs: GUERRA, STEFANO  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 6 year old;Accounting;Address;Adult;airway epithelium;airway hyperresponsiveness;allergic airway disease;Asthma;asthmatic;biobank;Biological Assay;Birth;Blood;Buffers;Child;Childhood;Childhood Asthma;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Circulation;CKB gene;Clinical Markers;cohort;Creatine;Creatine Kinase;Data;Disease;Elements;Enzymes;Epidemiology;Epithelial Cells;experimental study;Future;Gene Expression;Homeostasis;Impairment;improved;Individual;Inflammation;International;Isoenzymes;Knowledge;Letters;Life;Link;long-term sequelae;Lung;Measurement;Mitochondria;Morbidity - disease rate;mortality;mouse model;Mucins;Mus;Myocardial Infarction;Natural History;novel therapeutic intervention;Participant;pharmacologic;Phase;Phosphocreatine;Play;population based;predictive marker;Predisposition;protective factors;Protein Isoforms;Proteins;Puberty;pulmonary function;Pyroglyphidae;Reaction;Reporting;resilience;Resolution;Risk;risk stratification;Role;School-Age Population;Serum;Severities;Symptoms;Time;Tissues;Validation;Whole Blood

PROJECT_TITLE: Creatine Kinase in the Natural History of Asthma

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: PROJECT NARRATIVE  Homologous recombination DNA repair is critical for repairing DNA damage induced by genotoxic carcinogens. Defective DNA repair leads to carcinogenesis. This study will examine the role of Polδ4, an important mediator of this DNA repair process, in lung carcinogenesis induced by well-established lung carcinogens.

PI_NAMEs: LEE, MARIETTA Y.;XU, DAZHONG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Agar;airborne carcinogen;Animals;Benzo(a)pyrene;Biological Assay;Cancer Etiology;Cancer Prevention Intervention;carcinogenesis;carcinogenicity;Carcinogens;Catalytic Domain;Cell Cycle;cell growth;Cell Line;Cell model;Cell Physiology;cell transformation;Cells;Cessation of life;chromium hexavalent ion;Chronic;Defect;DNA Adducts;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Polymerase III;DNA Repair;Dose;driving force;Elements;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;Event;Excision Repair;experience;Exposure to;Future;Genes;Genomic DNA;genotoxicity;Goals;Hallmark Cell;homologous recombination;Human;in vivo;in vivo Model;Ketones;Knock-out;Knockout Mice;Laboratories;Lung;lung cancer cell;lung cancer prevention;lung carcinogenesis;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediator;Modeling;Molecular;Molecular Abnormality;mouse model;Mus;Mutation;Neoplastic Cell Transformation;Nicotine;Nitrosamines;novel;Nude Mice;Occupational;Pathologic;Pathway interactions;Play;Process;Regulation;repaired;Research;response;Role;Route;S phase;subcutaneous;System;Testing;Therapeutic;Therapeutic Intervention;Time;TNFRSF5 gene;tool;tumor;tumor DNA;tumorigenesis;ubiquitin ligase;ubiquitin-protein ligase;Urethane;Validation;Wild Type Mouse;Work;Xenograft Model Antitumor Assays;Yeasts

PROJECT_TITLE: The role of DNA Polymerase Delta 4 in Lung Carcinogenesis Induced by Genotoxic Carcinogens

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cellular senescence has recently been found to play a critical role in the pathogenesis of Alzheimer’s disease (AD), but the underlying mechanism is not clear. This project will dissect the roles of two major senescence pathways in the development of AD cellular pathologies using induced pluripotent stem cell-based AD models. The research will provide new insight into senescence’s role in AD and the impact of aging on AD pathogenesis.

PI_NAMEs: ZHANG, HONG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Apoptosis;Astrocytes;beta amyloid pathology;Biological Markers;Brain;brain cell;Cell Aging;cell type;Cells;cellular pathology;Cerebrum;Characteristics;Cognition;Cognitive deficits;CRISPR interference;Development;Disease;disease model;DNA Damage;Endosomes;Endothelial Cells;Fibroblasts;Functional disorder;Genetic;Goals;Heterogeneity;Human;human induced pluripotent stem cells;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inducible gene expression;insight;Mediating;Memory;Microglia;Molecular;mouse model;Nerve Degeneration;Neuronal Differentiation;Neurons;oligodendrocyte progenitor;Organoids;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;pharmacologic;Physiological;Play;Population;postmitotic;prevent;programs;Proliferating;protein complex;Regulation;Research;Resources;response;Retinoblastoma Protein;Role;senescence;senescent cell;Signal Transduction;stem cells;Stimulus;System;tau Proteins;tau-1;Tauopathies;telomere;Telomeric Repeat Binding Protein 2;tool;TP53 gene;transcriptomics;Variant

PROJECT_TITLE: Dissecting the impact of senescence pathways on the cellular pathogenesis of Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Although aberrant PARP1 activation is linked to many neurodegenerative disorders (e.g., C9orf72-mediated amyotrophic lateral sclerosis and frontotemporal dementia or C9orf72-ALS/FTD), how protein Poly-ADP- ribosylation (PARylation) signaling contributes to the pathogenesis of these dementias is poorly understood. In this proposal, we will develop a multiplexed proteomic approach for the global, quantitative and site-specific characterization of the Asp-/Glu-PARylated proteome in C9orf72-ALS/FTD. Combined with functional studies, we will elucidate how deregulated protein PARylation events cause neurodegeneration in C9orf72-ALS/FTD.

PI_NAMEs: SUN, SHUYING ;YU, YONGHAO  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;ADP ribosylation;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Bar Codes;Binding;Binding Proteins;Biochemical;Bioinformatics;bioinformatics tool;biological adaptation to stress;Biological Assay;Biological Markers;Biological Process;Biology;brain dysfunction;brca gene;c9FTD/ALS;C9ORF72;cell type;Cells;Cellular biology;Cellular Stress;Cerebellar Ataxia;Cessation of life;Chemicals;Collaborations;Data;data access;data dissemination;Data Set;Databases;Defect;Dementia;Derivation procedure;design;Dipeptides;Disease;DNA;DNA Damage;DNA Repair;enzyme substrate;Enzymes;Event;experience;experimental study;Expression Profiling;Family;FDA approved;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic;genetic approach;Genotoxic Stress;Heterogeneous-Nuclear Ribonucleoproteins;Human;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;inhibitor;instrument;Label;Link;Malignant Neoplasms;Mediating;Messenger RNA;Metabolism;Methods;Modeling;Motor Neurons;Mutate;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;Neurons;novel strategies;Nuclear Protein;Output;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Peptides;pharmacologic;Phase Transition;Physical condensation;Poly(ADP-ribose) Polymerases;Polymers;Post-Translational Protein Processing;Preparation;protein aggregation;protein expression;Proteins;Proteome;Proteomics;Publishing;response;RNA;Role;Sampling;self assembly;Series;side effect;Signal Transduction;Signaling Protein;Site;Stress;System;Technology;Time;Traumatic Brain Injury;user-friendly;Variant;virtual;Visualization;web portal;Work

PROJECT_TITLE: Multiplexed Quantification of the Protein Poly-ADP-Ribosylation Landscape in C9ORF72-ALS/FTD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (80)]


ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: This project will characterize and optimize a novel time and cost saving toolkit that allows simple, rapid, and robust activation of gene expression in the widely used model organism C. elegans, bringing new capabilities to systematically test the effect of gene activation in a broad range of biological problems. These capabilities will be employed to search for novel genes whose activation promotes healthy aging and increases lifespan, an important task unmet by existing tools. When complete, our work will broaden our general understanding of the genetic mechanisms that participate in aging and will identify novel potential targets for anti-aging drugs and therapies. 1

PI_NAMEs: APFELD, JAVIER  (contact);LEVINE, EREL

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age acceleration;age-related disease;Aging;aging related disease;anti aging;anti aging drug;Bacteria;Biological;C. elegans genome;Caenorhabditis elegans;Candidate Disease Gene;candidate selection;Code;Collaborations;Communities;Cost Savings;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Development;Disease;Escherichia coli;extend lifespan;feeding;Foundations;Gene Activation;gene conservation;Gene Expression;gene function;Gene Mutation;Genes;Genetic;genetic approach;Genome;genome-wide;Goals;Guide RNA;Health;healthy aging;Human;innovation;insight;interest;Intervention;Joints;knock-down;Knowledge;Libraries;life span;Link;Longevity;Maintenance;Metabolism;model organism;Molecular Biology;Nematoda;Neurons;novel;novel strategies;novel therapeutics;Organism;overexpression;Plasmids;prevent;Process;Promoter Regions;prospective;Proteins;Reagent;Regulation;Repression;Research;resilience;resilience in aging;Risk Factors;RNA Interference;Role;stress resilience;Systems Biology;Technology;Testing;Time;Tissues;tool;Transcriptional Activation Domain;Work

PROJECT_TITLE: Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative: The overall goal of the research outlined in this grant application is to better define the mechanisms by which airway mucosal irritation is transduced into airway defensive reflexes such as cough and bronchospasm. We will focus specifically on the role of the brush cells in the airway epithelium and on the actions of the transmitters and mediators released by brush cells.

PI_NAMEs: CANNING, BRENDAN J (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accounting;Acetylcholine;Acids;Acute Disease;afferent nerve;Afferent Neurons;Air;airway epithelium;airway surface liquid;Allergens;Anatomy;Applications Grants;associated symptom;Autacoids;Belief;Bronchial Spasm;Brush Cell;Carbon Dioxide;carbonate dehydratase;Cavia;Cell Communication;cell type;Cells;Cellular biology;cholinergic;chronic respiratory disease;Coughing;Disease;effective therapy;Electrophysiology (science);Experimental Designs;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Extracellular Matrix Proteins;Functional disorder;Future;Gases;Goals;Human;Immune;in situ imaging;Infection;Inflammatory;innovation;Interoception;Ion Channel;Irritants;irritation;Knowledge;Laboratories;Legal patent;Location;Lung;Lung Diseases;Mammals;Mediator;Molecular;Mucous body substance;Mucous Membrane;Mus;Nerve;Neurons;novel;Optics;pathogen;Patients;Peripheral;pharmacologic;Physiological;preservation;Productivity;Property;pulmonary function;Reaction;receptor;Receptor Cell;Reflex action;Research;Research Proposals;Respiratory Disease;Respiratory Mucosa;respiratory reflex;Respiratory Signs and Symptoms;response;Role;Sensory;Signal Transduction;Structure;Submucosa;System;targeted treatment;Taste Buds;Techniques;Testing;Tongue;transcriptome sequencing;Transgenic Organisms;transmission process;Work of Breathing

PROJECT_TITLE: Interoceptive functions of airway brush cells

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: MIAMI

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The proposed research aims to understand and discover the biological factors of health disparities in lung cancer between African Americans and European Americans at the multi-omics level. An explainable artificial intelligence-based computational framework will be developed using a cooperative game theory-based machine learning approach, first, to identify patient-specific tumor heterogeneity or disparity information, second, to identify cohort-specific disparity information, and third, to discover disparity between two cohorts. The developed tool will help decipher the race- and sex-specific risk factors such as African American Males, European American Males, African American Females, European American Females, etc., which will guide better treatment strategy, thus, benefitting humanity.

PI_NAMEs: MONDAL, ANANDA MOHAN (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: African American;African American population;African American Women;American;Biological Factors;Businesses;cancer health disparity;cancer type;Cessation of life;cigarette smoking;Classification;cohort;Communities;Complex;computer framework;computerized tools;Copy Number Polymorphism;Death Rate;design;Development;Disease;Disparity;DNA Methylation;epidemiology study;Epigenetic Process;epigenomics;Ethnic Origin;European;exome sequencing;explainable artificial intelligence;Female;Game Theory;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Markers;genetic risk factor;genome wide association study;Genomics;Goals;health disparity;Heterogeneity;Humanities;improved;Incidence;Individual;individual patient;innovation;Label;Location;Lung Adenocarcinoma;Machine Learning;machine learning framework;male;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Medical;Modeling;mortality;mRNA Expression;Multiomic Data;multiple omics;Mutation;Outcome;overexpression;Patients;personalized approach;population based;Population Study;precision medicine;Predisposition;profiles in patients;Property;Race;rational design;Reduce health disparities;Renal Carcinoma;Research;Risk;Risk Factors;risk variant;Sampling;sex;Smoking;specific biomarkers;Squamous Cell Lung Carcinoma;Structure of parenchyma of lung;Testing;Therapeutic;Tissue-Specific Gene Expression;tool;transcriptome;transcriptomics;treatment strategy;trend;tumor;tumor heterogeneity;United States;Work

PROJECT_TITLE: Explainable AI-Based Multi-Omics Analysis of Lung Cancer Health Disparity

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE How does Merkel cell polyomavirus (MCPyV) infect most children and young adults, and remain quiescent for decades, but then re-emerge as an active infection to be transmitted to other individuals years later? During MCPyV reactivation, mutations may occur that drive the virus to cause Merkel cell carcinoma, one of the most severe skin cancers, in susceptible people. Understanding MCPyV quiescence and replication is critical to developing therapeutic and preventive measures for this cancer virus.

PI_NAMEs: CHANG, YUAN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Automobile Driving;B-Lymphocytes;Binding;Binding Proteins;Binding Sites;Biological Assay;Cell Cycle;Cell Cycle Stage;Cells;Child;Chronic;chronic infection;combinatorial;CRISPR library;CRISPR screen;Disease;DNA;DNA biosynthesis;DNA Integration;DNA Tumor Viruses;Early Gene Transcriptions;Elements;Ensure;Episome;Equilibrium;F Box Domain;Feedback;Gene Expression Profile;General Population;Genetic Transcription;Genome;helicase;Herpesviridae;Human;Iatrogenesis;Immune;immune clearance;Immune system;Immunocompromised Host;Immunologic Surveillance;Immunosuppression;In Situ;Individual;Infection;Interruption;Kinetics;Knock-out;knockout gene;Laboratories;Large T Antigen;Late Gene Transcriptions;Life Cycle Stages;live cell imaging;Lytic;Malignant Neoplasms;Maps;Measurement;Mediating;Merkel cell carcinoma;Merkel Cells;MicroRNAs;Molecular;Monitor;mutant;Mutation;new technology;novel;Oncoproteins;Patients;Persons;Polyomavirus;Polyomavirus Infections;Predisposition;Preventive measure;promoter;Proteins;reactivation from latency;recruit;Regulation;Replication Initiation;Reporter;Research;Retroviridae;Role;screening;single cell technology;single molecule;Site;Skin Cancer;System;targeted treatment;Therapeutic;transcription factor;Transcriptional Regulation;transmission process;ubiquitin-protein ligase;Viral;viral DNA;Viral Genome;viral transmission;virology;Virus;Virus Activation;Virus Diseases;Virus Latency;Virus Replication;Visualization;young adult

PROJECT_TITLE: Mechanism For Merkel Cell Polyomavirus Persistence

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: This project seeks to provide a deeper understanding of the brain renin-angiotensin system in the progression of Alzheimer's disease (AD) pathology and contribution of high blood pressure to AD risk. This project holds the potential to unveil new therapeutic possibilities for the prevention or delay of AD onset and progression.

PI_NAMEs: MARVAR, PAUL J;NEMES, PETER  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Address;advanced analytics;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Angiotensin II;Angiotensins;Anti-Hypertensive Agents;Area;Behavioral;bioinformatics tool;Biological;biological systems;Blood - brain barrier anatomy;Blood Pressure;Blood Pressure Monitors;blood pressure regulation;Brain;Brain region;Cardiovascular Diseases;Cardiovascular system;Cognition;Cognitive;comorbidity;Data;Data Analyses;Dementia;dementia risk;Detection;Diabetes Mellitus;Disease;Disease Progression;Disease susceptibility;Disparity;early onset;Early Onset Alzheimer Disease;effective therapy;Endocrine system;Equilibrium;experimental group;Face;Female;Generations;genome wide association study;Gliosis;Hippocampus;Hormonal;Human;hyperphosphorylated tau;Hypertension;Impaired cognition;improved;Individual;Individual Differences;insight;Investigation;Knowledge;Late Onset Alzheimer Disease;Link;male;Mass Spectrum Analysis;Measures;Mediating;Mediator;Memory;Metabolic;model design;Molecular;mouse model;Mouse Strains;multidimensional data;Mus;Mutation;neurobiological mechanism;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;Neuropeptides;novel;novel therapeutics;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Predisposition;prevent;Prevention;Process;Renin-Angiotensin System;Research;resilience;Risk;Risk Factors;Risk Reduction;Rodent;Role;Senile Plaques;sex;Statistical Data Interpretation;Symptoms;System;technological innovation;Technology;Testing;Therapeutic;tool;Transgenes;United States;women versus men

PROJECT_TITLE: Microanalytical Peptide-Peptidase Profiling of the Brain Renin-Angiotensin System in a Genetically Diverse Alzheimer's Disease Mouse Model

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Post-acute sequelae of COVID-19 (PASC), also known as “long COVID”, poses a significant burden on global health systems. In the current project, using hiPSC-based 2-D microglia and 3-D organoid models, we aim to identify brain-specific responses to SARS-CoV-2 that likely contribute to neurological sequelae caused by PASC. Our study will provide novel insight into how different SARS-CoV-2 strains affect microglia function including microglia-neuronal crosstalk, and facilitate the identification of druggable targets for treatment of PASC.

PI_NAMEs: LECHER, JULIA C.;WEN, ZHEXING  (contact)

PROGRAM_OFFICER_NAME: SAWAKI-ADAMS, LUMY

PROJECT_TERMS: 2019-nCoV;3-Dimensional;acute COVID-19;Address;Affect;aging related;Animal Model;ATAC-seq;Autopsy;Biological Markers;Brain;brain fog;brain tissue;Calcium;Cell Line;Cell Physiology;Cells;Central Nervous System;Cessation of life;Characteristics;Cholesterol Homeostasis;clinically relevant;Communication;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;cytokine;Data;Development;drug development;druggable target;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;experience;experimental study;Fatigue;Fatty Acids;FDA approved;Functional disorder;Funding;Future;Gene Cluster;Genes;Genetic Transcription;glial activation;global health;Goals;gray matter;Health system;Homeostasis;Human;human induced pluripotent stem cells;Image;Immune;Immune response;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vitro Model;Incidence;induced pluripotent stem cell;induced pluripotent stem cell technology;Infection;Inflammasome;Inflammatory;Inflammatory Response;innovation;insight;Interferons;Knowledge;Least-Squares Analysis;Long COVID;Maintenance;Mediating;Medical center;Mental disorders;Metabolic;Metabolic Pathway;metabolomics;Microglia;Modeling;Molecular;molecular marker;Morbidity - disease rate;Morphology;mortality;multi-electrode arrays;Multiomic Data;multiple omics;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurologic;Neurologic Effect;Neurologic Symptoms;neuron loss;Neurons;novel;Organoids;Oxidative Phosphorylation;Pathogenicity;Patients;Phagocytes;Pharmaceutical Preparations;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Preventive measure;Production;Proteins;psychiatric symptom;response;Role;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 variant;severe COVID-19;single nucleus RNA-sequencing;stem cell technology;Symptoms;TNF gene;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Vaccination;Variant;Viral;Virion;Washington

PROJECT_TITLE: Leveraging iPSC technology to understand neuro-immune responses to SARS-CoV-2 variants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (57)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: NARRATIVE Policies that restrict immigrants’ access to health and other services can erode both mental and physical well- being. We propose to conduct a novel data linkage to analyze how such policies and immigration enforcement associate with measures of diet and obesity for children of Mexican immigrants using nationally-representative data collected across 10+ years. Findings from this study will advance our understanding of the multiple levels of influence that immigration policy climates can impact children of Mexican immigrants, and may in part explain why this important and growing group faces a higher burden of obesity than their non-Hispanic White peers.

PI_NAMEs: FERNANDEZ-RHODES, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 18 year old;Acculturation;Adolescent;Adoption;Affect;Age;Area;biobehavior;Body mass index;Child;Child Behavior;Child Health;Child Welfare;Childhood;Cities;Climate;Communities;comorbidity;Country;County;COVID-19 pandemic;Data;Data Linkages;data resource;Data Set;Destinations;Development;Diet;Diet Modification;dietary;Dietary Intervention;Discrimination;Disparity;Documentation;Employment;Exclusion;experience;Exposure to;Face;Family;Family health status;Fright;Goals;Grant;Health;Health Care Seeking Behavior;health care service utilization;healthy weight;higher education;Hospitalization;Immigrant;Immigrant family;Immigration;interest;Law Enforcement;Laws;Life;Life Style;Link;longitudinal analysis;male;Measures;Methods;Mexican;Mexican Americans;Mexico;Modeling;National Health and Nutrition Examination Survey;National Institute of Child Health and Human Development;North Carolina;Not Hispanic or Latino;novel;Obesity;obesity in children;obesogenic;Overweight;Parents;peer;Personal Satisfaction;Policies;Population;Population Study;Pregnancy Outcome;primary outcome;programs;Psyche structure;Psychosocial Assessment and Care;Psychosocial Stress;psychosocial stressors;Public Health;public health intervention;Quasi-experiment;Research;Secure;Services;sex;Shapes;social stigma;Stress;stressor;structural determinants;Time;United States;Vulnerable Populations;Weight;weight maintenance;welfare;Work;young adult

PROJECT_TITLE: Immigration Policies, Dietary Acculturation, and Childhood Obesity.

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This project will investigate the role that cognitive health plays in socioeconomic success and wellbeing during the transition from adolescence to early adulthood using data from the Study of the Tsunami Aftermath and Recovery (STAR), a 15-year panel study of coastal communities, households, and individuals in Aceh and North Sumatra on the island of Sumatra in Indonesia, who were at risk of exposure to the 2004 Indian Ocean earthquake and tsunami and representative of the pre-disaster population, as well as a specially-designed subcomponent of STAR, the Extended Assessment of Biomarkers and Cognition (EABC), which involves two- rounds of longitudinal data of a 25% randomly-selected subsample of STAR respondents that includes a tablet-based approach to precisely measuring seven different cognitive skills using game-like tasks adapted for the setting from widely-used assessments. In contrast to previous studies of cognitive functioning and socioeconomic outcomes, which have largely focused on broader, higher-level measures of cognition in high- income countries, this project uses these innovative data to provide evidence on domain-specific cognitive skills founded in neuroscience for a population-representative sample in a developing country. We will also use the richness of the STAR data to examine the role of parental and family background characteristics in the association between cognition and early adult outcomes and will leverage the unanticipated nature of the tsunami to examine the role of a large unanticipated natural disaster in moderating those relationships.

PI_NAMEs: INGWERSEN, NICHOLAS S (contact)

PROJECT_TERMS: 8 year old;acetone hydrazone;Address;Adolescence;Adopted;Adult;Adverse event;Attitude;Behavior;Biological Markers;Characteristics;Child;Childhood;Cognition;Cognitive;cognitive development;cognitive function;cognitive performance;cognitive skill;cognitive task;Collaborations;Communities;Country;Data;design;Developing Countries;Dimensions;Disasters;Earthquakes;economic outcome;Education;emerging adult;Environmental Risk Factor;executive function;Exposure to;Family;family building;Fertility;follow-up;Foundations;Genetic;Goals;Health;Household;Household Consumptions;Income;Indian Ocean;Individual;Indonesia;innovation;insight;Intelligence;Investments;Island;Life;Link;Liquid substance;Longitudinal Studies;Longitudinal Surveys;Marketing;Marriage;Measures;Modeling;Natural Disasters;Nature;Neurosciences;novel;Occupations;Outcome;parental role;Performance;Personal Satisfaction;Play;Population;Prospective Studies;Random Allocation;reconstruction;Recovery;Research;Resource-limited setting;Resources;Respondent;Risk;Role;Sampling;Shapes;Shock;Siblings;socioeconomics;success;Sumatra;Surveys;Tablets;Time;transition to adulthood;Tsunami;Variant;young adult

PROJECT_TITLE: Cognitive performance following a natural disaster and demographic and socioeconomic outcomes


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: FORDHAM UNIVERSITY

PHR: Narrative Brain disorders including the most frequent mental disorders, anxiety and depression, show significant sex bias in prevalence and severity. The major factors that cause brain sex differences are gonadal hormones (estrogen and progesterone in women; testosterone in men) and sex chromosomes (XX in women; XY in men). By decoding female-specific X chromosome plasticity in the brain, induced by ovarian hormones, this study will open new, sex- and gender-informed avenues for treatments, with important implications for women’s brain health.

PI_NAMEs: KUNDAKOVIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 3-Dimensional;Address;Adult women;Alleles;Animals;Anxiety;Anxiety Disorders;anxiety-related behavior;autosome;Behavior;Behavior Control;behavior test;Behavioral;Bioinformatics;Biological Assay;Biology;Brain;Brain Diseases;brain health;brain shape;Breathing;C57BL/6 Mouse;Cells;Chromosomes;Data;Data Analyses;Development;disorder risk;Dosage Compensation (Genetics);Dose;Ensure;Environment;epigenomics;estrogenic;Estrogens;Estrous Cycle;Female;Gender;Gene Dosage;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Models;Genome;Genomics;Global Change;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Heterozygote;Hi-C;Hippocampus;Hormonal;Hormones;insight;Link;male;men;Mental Depression;Mental disorders;Mental Health;Modeling;Molecular Conformation;mouse genetics;mouse model;Mus;mutant;Mutant Strains Mice;Neuroendocrinology;Neurons;neuropsychiatric disorder;novel;Ovarian Cycles;Ovarian hormone;Partner in relationship;Periodicity;Phase;Ploidies;Positioning Attribute;Prevalence;Progesterone;Regulation;Repression;reproductive hormone;Research;response;Risk;Role;Scientist;Severities;sex;Sex Bias;Sex Chromosomes;Sex Differences;Somatic Cell;Structure;Testing;Testosterone;Tissues;tool;transcriptome sequencing;Woman;X Chromosome;X Inactivation

PROJECT_TITLE: Decoding the X-chromosome Dynamics in the Adult Female Brain

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Diabetic kidney disease (DKD) is the leading cause of ESRD in the USA with increasing prevalence at an alarming rate worldwide, and there are no known cures to prevent its progression. We have identified a new risk variant that controls the oxidation state of cells in the kidney in DKD susceptible mice, and plan to develop a new precision medicine therapeutic strategy. The proposed studies will uncovered XOR promoter orthologue variants in humans associated with significant risk for DKD, and provide new avenues for more effective and precise therapies for patients at risk and living with this disease.

PI_NAMEs: DAEHN, ILSE SOFIA (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;aged;Aging;Albuminuria;Animals;base editing;Binding Sites;biobank;Blood Glucose;C57BL/6 Mouse;Cardiovascular Diseases;cardiovascular risk factor;Cells;Chromosome Mapping;Chromosomes;cis acting element;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Complications of Diabetes Mellitus;curative treatments;Data;DBA/2 Mouse;design;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetic patient;Disease;Disease Progression;Disease Resistance;Disease susceptibility;disorder risk;DNA;DNA Damage;DNA Double Strand Break;End stage renal failure;Endothelial Cells;Endothelium;Environment;Experimental Models;Focal and Segmental Glomerulosclerosis;Functional disorder;Future;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Risk;genome editing;genome-wide;genomic locus;glomerular endothelium;high risk;Human;Human Genetics;in vitro testing;in vivo;Inbred Mouse;Inbred Strains Mice;Inbreeding;Injury;Injury to Kidney;insight;Kidney;Kidney Diseases;Kidney Failure;Knock-in;Lead;Lesion;Mediating;Mitochondria;Mitochondrial DNA;Molecular;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutation;novel therapeutics;Nucleic Acid Regulatory Sequences;Organelles;oxidation;Oxidative Stress;Oxidoreductase;oxidoreductase inhibitor;Pathogenesis;Patients;Phenotype;podocyte;Positioning Attribute;precision medicine;Predisposition;Prevalence;prevent;prime editing;prime editor;Production;promoter;Publishing;Quantitative Trait Loci;Reactive Oxygen Species;Recombinants;Regulation;Resistance;Risk;risk variant;Rodent Model;Role;small molecule inhibitor;Source;Stress;targeted treatment;Technology;Therapeutic;transcription factor;United States;Uric Acid;Variant;Work;XDH gene

PROJECT_TITLE: Genetic risk and molecular characterization of Diabetic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Sleep Research;Suicide

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Sleep depth, intensity and integrity are important contributors to optimal health that, when disrupted, can escalate vulnerability to mood and behavioral problems in youth. We propose to study the impact of abnormal developmental trajectories of the sleeping brain with psychopathology in young adulthood by leveraging data from a 15-year longitudinal study of a unique cohort of children from the general population recruited for a prior R01. Findings from this study will inform novel biomarkers for clinical trials that aim at improving the pathophysiology and long-term prognosis of diverse forms of psychopathology across the life span by targeting the sleeping brain.

PI_NAMEs: FANG, JIDONG ;FERNANDEZ-MENDOZA, JULIO  (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 20 year old;Address;Adolescence;Adolescent;Age;age related;aged;Anatomy;Anterior;anti-depressive agents;Attention;Attention deficit hyperactivity disorder;Biological;Biological Markers;Brain;Child;Childhood;Clinical;Clinical Trials;cohort;comorbidity;critical period;Data;density;Development;Diagnostic;Disease;Disease susceptibility;Electroencephalography;externalizing behavior;Feasibility Studies;Feeling suicidal;Female;follow-up;Functional disorder;General Population;Grain;Health;high reward;Impairment;improved;Learning Disorders;Life;life span;Longitudinal Studies;male;Measures;Mental disorders;Mental Health;Minority;Moods;myelination;National Institute of Mental Health;neural;neuroimaging;neurophysiology;novel;novel marker;Odds Ratio;Outcome;Patient Self-Report;Phase;Physiological;Play;population based;Population Study;primary outcome;Problem behavior;Prognosis;Psychopathology;Psychoses;Puberty;recruit;Research Personnel;Research Priority;Risk;Risk Factors;Role;Severities;sex;Sex Differences;Short-Term Memory;Signal Transduction;Sleep;Sleep disturbances;sleep spindle;Stimulant;suicidal;Suicide attempt;Symptoms;synaptic pruning;Testing;young adult;Youth

PROJECT_TITLE: Developmental Trajectories of Sleep EEG Biomarkers and Risk of Psychopathology Through Young Adulthood

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it aims to study competitive interactions between the commensal bacterium Dolosigranulum pigrum and the pathobiont Staphylococcus aureus to identify novel and specific anti-S. aureus metabolites. This research will address the urgent need for therapeutics to combat drug- resistant S. aureus infections, while minimizing disruption to the endogenous nasal microbiome caused by traditional antibiotics.

PI_NAMEs: STUBBENDIECK, REED M (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Adult;Alleles;Animals;Anterior nares;Antibiotics;antimicrobial;Bacteria;bacterial genetics;Biological Assay;Biology;candidate identification;Chemicals;Child;chronic rhinosinusitis;Coculture Techniques;combat;commensal bacteria;commensal microbes;Complement;Development;DNA;Drug resistance;ear infection;Electroporation;Environment;expectation;experience;Future;Gene Cluster;Genes;Genetic;genetic manipulation;Genome;Goals;Growth;Habitats;Health;Health Care Costs;Heart;Human;In Vitro;in vivo;ineffective therapies;Infection;innovation;interest;Laboratories;lactic acid bacteria;Lead;Life;Link;Mass Spectrum Analysis;Mediating;Methicillin;methicillin resistant Staphylococcus aureus;Methods;microbiome;microbiome research;Mining;Modeling;Molecular;multi-drug resistant pathogen;mutant;Nasal cavity;nasal microbiome;nasal swab;Natural Products Chemistry;NMR Spectroscopy;Nose;novel;novel therapeutics;Opportunistic Infections;opportunistic pathogen;Organism;pathobiont;pathogenic bacteria;Patients;Peptides;Persons;Phylogenetic Analysis;Plasmids;Polyethylene Glycols;Population;Positioning Attribute;prevent;Production;Public Health;Recurrence;Reporting;Research;Research Personnel;Resistance;Resource-limited setting;Respiratory Tract Infections;Ribosomes;Risk Factors;Role;secondary infection;secondary metabolite;Sepsis;Skin;Specimen;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;Stress;Structure;System;Testing;Therapeutic;tool;United States;Upper respiratory tract;uptake;Vancomycin;Vancomycin Resistance;Vancomycin-resistant S. aureus;Work

PROJECT_TITLE: Identification of Anti-Staphylococcus aureus Metabolites Produced by Dolosigranulum pigrum from the Human Nose

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Abdominal aortic aneurysms occur when the wall of the aorta becomes weakened causing the aorta to grow and eventually rupture. We intend to study the effect of photodynamic therapy (PDT) on aortic aneurysms to identify if PDT can slow aneurysm growth.

PI_NAMEs: OSKOWITZ, ADAM  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Abdominal Aortic Aneurysm;Affinity;Aneurysm;Aorta;Aortic Aneurysm;Blood Vessels;Cause of Death;Cell Physiology;Cells;Chronic;Clinical;Collagen;Collagen Fiber;crosslink;Data;Death Rate;Deceleration;design;Development;Disease;Dyes;Elastin;Enzymes;Event;Extracellular Matrix;Extracellular Matrix Degradation;Extracellular Matrix Proteins;Gene Expression;Growth;high risk;Human;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;Immunosuppression;Inflammation;Inflammatory;inflammatory milieu;inhibitor;insight;Light;Malignant Neoplasms;Mediating;Medical;Metalloproteases;Methylene blue;Molecular Analysis;mouse model;Mus;Operative Surgical Procedures;Pathway interactions;Patients;Peptide Hydrolases;Photosensitizing Agents;Physiological;Proliferating;protective effect;protein degradation;Proteins;Protocols documentation;PUVA Photochemotherapy;repaired;Resistance;Rupture;Secondary to;Testing;Therapeutic;Time;Tissues;transcriptome;Tunica Adventitia;vascular inflammation

PROJECT_TITLE: Photodynamic Therapy for Aortic Aneurysms

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Public Health Statement Traumatic brain injury (TBI), even in its mildest form, can lead to long-lasting disability and cognitive dysfunction. The neural mechanisms underlying TBI-associated memory dysfunction have not been fully delineated nor are effective strategies to improve learning and memory available. The present proposal will investigate if stimulation of sharp wave-ripples in the hippocampus can be used to improve hippocampus-dependent memory after TBI.

PI_NAMEs: DASH, PRAMOD K (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Air;Animals;antagonist;awake;Bilateral;Blast Injuries;Brain Injuries;Brain region;Clinical Research;Consensus;Data;Decision Making;disability;Dorsal;Dose;Event;experience;Experimental Models;experimental study;extracellular;Female;Fire - disasters;fluid percussion injury;Frequencies;functional improvement;Head;High Frequency Oscillation;high reward;high risk;hippocampal pyramidal neuron;Hippocampus;Human;hypocretin;Immobilization;Impaired cognition;Impairment;Implant;Implanted Electrodes;improved;improved outcome;Injury;Interneurons;Knowledge;Lateral;Learning;Location;long term memory;male;Memory;memory consolidation;Memory impairment;memory retention;mild traumatic brain injury;neural;neural circuit;neuromechanism;neuron loss;Neuronal Plasticity;neuronal survival;Neurons;non rapid eye movement;novel;optogenetics;orexin 1 receptor;Patients;Pattern;Persons;pharmacologic;Phase;Play;prevent;Process;Property;Public Health;Quality of life;Rattus;Recovery;Recurrence;Reporting;Research;Research Personnel;Risk;Role;Severities;sham surgery;Short-Term Memory;Signal Transduction;Sleep;social;Sprague-Dawley Rats;Stimulus;System;Testing;Time;Training;Traumatic Brain Injury

PROJECT_TITLE: Sharp wave ripple stimulation as a potential strategy to enhance memory after TBI

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is a critical need for noninvasive and robust endometriosis detection technologies. Although exhaled breath-based endometriosis detection can offer those advantages, primarily due to the lack of sensitivity and reliability of existing engineered gas sensors, exhaled breath-based disease diagnosis has not been implemented in clinical settings. In this proposal, we systematically validate and quantify the performance of our novel olfactory neuron-based gas sensor for early and robust detection of endometriosis using 2-D cell cultures, 3-D organoids, and in a mouse model of endometrisois.

PI_NAMEs: FAZLEABAS, ASGERALLY T. (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Animals;Biological;Biological Markers;Biomedical Engineering;Biosensing Techniques;Biosensor;Blood;Brain;brain based;cancer biomarkers;Cancer Detection;Canis familiaris;Cell Culture Techniques;Cell Line;Cells;Cellular Metabolic Process;Chemicals;Chronic;chronic pelvic pain;Classification;Clinical;cost;Coupled;Coupling;D Cells;Data Analyses;Detection;Devices;Diagnosis;diagnosis standard;diagnostic tool;Disease;disease diagnosis;Disease Progression;Dysmenorrhea;Dyspareunia;Early Diagnosis;electronic nose;Emotional;Endometrial;endometriosis;Engineering;Estrogens;Etiology;Exhalation;Financial Hardship;Gases;Goals;Growth;Healthcare Systems;Heterogeneity;Histologic;Human;Image;In Vitro;in vivo;Infertility;Inflammatory;innovation;Insecta;Laparoscopic Surgical Procedures;Lesion;Link;Lobe;locust;malignant mouth neoplasm;Malignant Neoplasms;Mass Fragmentography;Metabolic;Metabolism;Methodology;mouse model;Mus;neural;neural circuit;Neurons;Non-Invasive Detection;non-invasive system;noninvasive diagnosis;Nose;novel;novel strategies;Olfactory Pathways;olfactory sensory neurons;Organoids;pain symptom;Pathogenesis;Patients;Pelvis;Performance;portability;Publishing;Quality of life;reproductive;Research;response;Sampling;screening;Sensitivity and Specificity;sensor;sensor technology;Sensory;sensory system;Smell Perception;spheroids;surgical risk;Symptoms;Techniques;Technology;Testing;Time;Tissues;tool;United States;urinary;Urine;Uterus;volatile organic compound;Woman;Work

PROJECT_TITLE: Noninvasive and early detection of endometriosis using a biological neural circuit-based novel gas sensor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (95)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MILFORD

ORG_NAME: INSTANOSIS, INC.

ORG_STATE: DE

PHR: Xylazine is a synthetic non-opioid alpha2-adrenergic agonist that has contributed increasingly to overdose deaths in the United States in recent years. We propose to develop and commercialize the first regulatory approved diagnostic device for rapid xylazine detection, using our patent pending InstaStrip technology. The resources developed in this proposal will serve as a blueprint to allow us to quickly modify the technology for other analytes and respond rapidly to emerging drug threats.

PI_NAMEs: WANG, PING ;XIA, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Address;Adrenergic Agonists;Affect;analog;Antibodies;Caring;Clinical;commercialization;Contracts;Data;design;Detection;detection sensitivity;Development;Devices;Diagnostic Equipment;Diagnostic Procedure;diagnostic screening;drug testing;Drug Use Disorder;Drug user;Emergency medical service;Enrollment;Epidemic;Epidemiology;Fentanyl;fentanyl use;head-to-head comparison;Human;Human Resources;Illicit Drugs;Individual;Instruction;Legal patent;manufacture;Manufacturer;Mass Spectrum Analysis;Medical;meetings;Mental Depression;mental state;Methods;Monoclonal Antibodies;Naloxone;non-opioid analgesic;opioid overdose;Overdose;overdose death;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Powder dose form;premature;prevent;programs;prototype;Public Health;Publishing;Rapid diagnostics;Rapid screening;rapid test;Regulatory Pathway;Research Design;Residual state;Resources;Sampling;screening;skin ulcer;synthetic drug;System;Technology;technology platform;test strip;Testing;Tranquilizing Agents;United States;Urine;usability;Validation;validation studies;verification and validation;waiver;Withdrawal;Work;Xylazine

PROJECT_TITLE: Addressing Emerging Drug Threats with InstaStrip Rapid Tests

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: NARRATIVE  “Dietary fructose and NASH/HCC progression”  The rapid rise of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) has correlated with has a corresponding increase in the prevalence of hepatocellular carcinoma (HCC). Dietary fructose is thought to be a major risk factor for NASH→HCC progression but the mechanisms linking dietary fructose to inflammation-dependent HCC progression are entirely unknown. This project seeks to investigate a highly novel mechanistic pathway that links dietary fructose consumption to inflammation-dependent HCC progression and will explore novel therapeutic approaches with which to target.

PI_NAMEs: MITCHELL, ROBERT A;SONG, MING  (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Automobile Driving;Blood;Consumption;Coupled;Data;Development;dietary;Enzymes;Epithelial Cells;Exhibits;Fatty acid glycerol esters;Fructose;fructose-1-phosphate;gastrointestinal system;Gene Deletion;Genetic Transcription;Glucose;Goals;Hypochromic anemia;Hypoxia;Hypoxia Inducible Factor;Inflammation;Inflammatory;inhibitor;intestinal epithelium;Intestines;Iron;iron absorption;Iron Chelating Agents;Iron Chelation;iron deficiency;Ketohexokinase;Link;Liver;Liver diseases;liver inflammation;Luciferases;Measures;Mediating;Metabolic;Mitochondria;Modeling;Mus;neutrophil;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Oxygen;Pathologic;Pathology;Pathway interactions;pharmacologic;Phosphoenolpyruvate;Physiological;Plasma;Prevalence;Primary carcinoma of the liver cells;Procollagen-Proline Dioxygenase;Proteins;Pyruvate;pyruvate carrier;Pyruvate Kinase;Reporter;Research Design;Risk Factors;SLC11A2 gene;small molecule inhibitor;stem;Streptozocin;systemic inflammatory response;Testing;therapeutic target;Therapeutically Targetable;tumorigenic;villin;western diet;Work

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE In this project we will develop and test innovative health information technology (IT) tools that support an outpatient geriatrics care Age-Friendly Learning Healthcare System with a point of care clinical decision support system that leverages patient generated health data (PGHD) and electronic health record (EHR) data reports that support Age-Friendly Health System care. The interoperable tools will be adaptable to additional healthcare systems using any EHR system and will incorporate data directly from patient reports using a patient generated data mobile application and EHR data to support clinicians and patients in shared decisions about age-friendly care. This work will support the emerging evidence base for Age-Friendly Health System care and specifically address the gap in knowledge and implementation of age-friendly approaches in geriatrics outpatient clinics.

PI_NAMEs: BUTLER, JORIE MICHAELA (contact);KAWAMOTO, KENSAKU

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: An Age-Friendly Learning Healthcare System: A Transformative Digital Solution for Geriatrics Clinics

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE To add genomic sequencing into public health newborn screening (NBS) in a way that maximizes benefits (e.g., access to life-saving treatments) and minimizes harm (e.g., treating healthy babies unnecessarily), NBS needs a way to determine for which genes babies should be screened. This project will use the experience of newborn sequencing researchers in combination with the public, parents, patients, and health professionals to identify gene selection criteria to guide ethical and appropriate decision-making on how to select genes to screen. The resulting gene selection criteria will reflect diverse perspectives and provide NBS with much needed guidance.

PI_NAMEs: PEAY, HOLLY LANDRUM (contact)

PROGRAM_OFFICER_NAME: JOSE, SHEETHAL

PROJECT_TERMS: Address;Adult;Advisory Committees;Advocate;Age of Onset;Agreement;Area;Behavioral Research;Beneficence;Benefits and Risks;Child;Child Welfare;Communities;community partners;Complex;Consensus;cost;Data;Decision Making;Ensure;Equilibrium;Equity;ethical, legal, and social implication;Ethics;experience;Future;future implementation;Genes;Genetic Diseases;Genomics;Guidelines;Harm Reduction;Health Professional;Individual;innovation;interest;Intervention;Interview;Life;Literature;Medical;member;multidisciplinary;Neonatal;neonatal health;Neonatal Screening;Newborn Infant;Outcome;Output;Parents;Patients;Penetrance;Pilot Projects;population based;preference;Process;professional partner;Public Health;Published Comment;Publishing;Recommendation;Reporting;Research;Research Personnel;research study;Respondent;Scanning;Science;screening;screening program;Selection Criteria;social;Source;Technology;Time;trustworthiness;United States;Update;uptake;Variant;Videoconferencing

PROJECT_TITLE: Gene Selection for Newborn Sequencing Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Regenerative Medicine;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Narrative The interactions of the brain and immune system are important in Alzheimer’s disease and other pathologies, yet are challenging to understand due to the limitations of animal models and very limited human cell culture models. Here we will develop an innovative, tissue engineered model of the communication between the human brain, meninges, and brain-draining lymph nodes. We will use this system to replicate neuroimmune outcomes in normal physiology and Alzheimer’s Disease, thus creating a platform for future study of neuro-inflammatory disease mechanisms and human-based drug testing.

PI_NAMEs: MUNSON, JENNIFER M (contact);POMPANO, REBECCA R

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Affect;Age;aged;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Animal Model;Antigens;Area;B-Lymphocytes;Back;Benchmarking;Biological Models;Biomimetics;Blood - brain barrier anatomy;Brain;brain circuitry;Brain Drains;brain tissue;CD8-Positive T-Lymphocytes;Cell Culture Techniques;cell motility;Cell secretion;Cells;Cervical lymph node group;Chemicals;Circulation;cohort;Communication;Complex;Cues;cytokine;Data;Development;Devices;Disease;Disease Progression;Drainage procedure;draining lymph node;drug testing;Elements;Encephalitis;Engineering;Ensure;Event;flexibility;fluid flow;Force of Gravity;Foundations;Frequencies;Future;glymphatic system;Housing;Human;human data;human model;immune function;Immune system;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Inflammatory;innovation;interstitial;Laboratories;Link;Liquid substance;lymph node microenvironment;Lymph Node Tissue;lymph nodes;Lymphatic;lymphatic drainage;Lymphatic System;Lymphocyte;Lymphoid;Malignant neoplasm of brain;Meningeal lymphatic system;Meninges;Microfluidic Microchips;Microfluidics;Microglia;microphysiology system;migration;Modeling;Motility;mouse model;Multiple Sclerosis;Mus;Mutation;Nerve Degeneration;nerve stem cell;Nervous System;Neuroglia;Neuroimmune;neuroimmunology;neuroinflammation;Neurons;next generation;novel;Onset of illness;Organ;organ on a chip;Outcome;Pathogenesis;Pathologic;Pathology;Patient Representative;Patients;Permeability;Pharmaceutical Preparations;Phenotype;Physiology;Process;programs;Proteins;Pump;recruit;Reporting;Research;response;Role;sex;Signal Transduction;Source;Stimulus;Structure;Superficial Cervical Lymph Node;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;Technology;Testing;three dimensional cell culture;tissue culture;Tissue Engineering;Tissue Microarray;Tissues;TNF gene;trafficking;trend;Tube;user-friendly;Variant;wasting;Work

PROJECT_TITLE: A microphysiological model of the brain-lymphatic system in Alzheimer's disease

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative:  During retinal development, progenitor cells show dramatic changes in their ability to proliferate and generate specific cell types, a process which is known as temporal patterning. We have recently identified many genes that are dynamically expressed in progenitors during retinal development. We plan to test whether and how they regulate temporal patterning during development and determine whether they can induce mature retinal glial cells to reprogram into progenitor cells that generate early-born neuronal cell types such as retinal ganglion cells and cone photoreceptor receptors. These studies have the potential to form the basis for effective for cell-based therapies aimed at restoring vision in degenerative blinding diseases such as macular degeneration and glaucoma.

PI_NAMEs: BLACKSHAW, SETH  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adult;Affect;Amacrine Cells;ATAC-seq;Blindness;Cell Cycle Progression;Cell Therapy;cell type;Cells;Chromatin;Competence;constitutive expression;Development;Developmental Course;directed differentiation;Disease;Electroporation;Family;gain of function;Gene Expression;gene function;gene regulatory network;gene repression;Genes;Glaucoma;Histologic;horizontal cell;improved;in vivo;loss of function;Macular degeneration;Molecular;Molecular Conformation;Muller's cell;multiple omics;mutant;Neuroepithelial Cells;neurogenesis;Neuroglia;Neurons;NFIA gene;notch protein;overexpression;Pathway interactions;Pattern;Phenotype;Predictive Factor;Process;progenitor;programs;Proliferating;receptor;Retina;Retinal Cone;Retinal Ganglion Cells;retinal progenitor cell;Rod;Role;sight restoration;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;stem cells;Techniques;Testing;Time;transcription factor;transcription regulatory network;Viral

PROJECT_TITLE: Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]