ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is a highly aggressive and deadly brain tumor, with current treatment strategies ineffective and highly debilitating. The proposed research aims to investigate the role of targeting multiple phagocytosis checkpoints expressed in GBM as a novel therapeutic approach using a newly developed bispecific CD47-B2m antibody. The results generated from the proposal will enhance our understanding of tumor immune escape and provide a novel therapeutic strategy for treating GBM as well as other malignant tumors.

PI_NAMEs: JIANG, WEN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adaptive immunity;Adult;Affect;Anti-CD47;anti-tumor immune response;Antibodies;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Antitumor Response;beta-2 Microglobulin;Binding;Bispecific Antibodies;blood-brain barrier crossing;blood-brain tumor barrier;Bone Marrow;Brain;Brain Neoplasms;cancer immunotherapy;CD47 gene;cell killing;Cell Separation;Cell surface;Cells;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collection;Colorectal Cancer;Colorectal Neoplasms;Combined Modality Therapy;conventional therapy;Critical Pathways;Cross-Priming;Cyclic GMP;Cytosol;Cytotoxic T-Lymphocytes;Data;Detection;Development;Disease;DNA Sequence Alteration;Eating;Effectiveness;efficacy evaluation;Ensure;Feedback;Glioblastoma;Glioma;Goals;Human;human model;Hybrids;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immunotherapeutic agent;improved;In Vitro;in vivo;Individual;Inflammatory;innate immune checkpoint;Innate Immune Response;innate immune sensing;Interferon Type I;Investigation;Kinetics;Knock-out;knockout animal;Lead;Leukocytes;Ligands;Macrophage;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mammary Neoplasms;Mediating;Microglia;Molecular;mouse model;Mus;Natural Immunity;neoplastic cell;novel;novel therapeutic intervention;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Phagocytes;Phagocytosis;Phagosomes;Play;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;Probability;Process;Production;Radiation;receptor;Receptor Signaling;reconstitution;Regimen;Research;Resistance;response;Role;Signal Transduction;spatiotemporal;standard care;Stimulator of Interferon Genes;success;T cell response;T-Lymphocyte;Therapeutic;Therapeutic antibodies;Therapeutic Effect;therapeutic target;Time;Toll-like receptors;treatment response;treatment strategy;tumor;tumor DNA;Tumor Escape;tumor growth;Tumor Immunity;Tumor Promotion

PROJECT_TITLE: Therapeutic targeting of multiple glioblastoma phagocytosis checkpoints using a novel bispecific antibody

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance Statement: Poly-substituted arenes and heteroarenes are ubiquitous in pharmaceuticals and approved drugs; however, the efficiency of using conventional approaches to access these structural motifs remains to be improved. The outlined proposal aims to enable new efficient catalytic methods for direct preparation of poly-substituted arenes and heteroarenes from readily available feedstocks. Success of the proposed research would significantly expedite the synthesis of complex aromatic molecules, which, in turn, would ultimately accelerate drug discovery.

PI_NAMEs: DONG, GUANGBIN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Directions in Palladium/Norbornene Cooperative-Renewal

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative  Retinal degeneration is the most common cause of untreatable blindness world- wide. The research proposed here will test hypotheses about how dying photoreceptors interact with resident immune cells, which help to remove debris and dying cells and can also secrete neurotrophic factors to support tissue repair and recovery. The ultimate goal of the work is to be able to delay or prevent photoreceptor degeneration through manipulation of the early immune response.

PI_NAMEs: BURNS, MARIE E (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: adaptive optics scanning laser ophthalmoscopy;Apoptosis;ARRB1 gene;Biochemical;Blindness;cell behavior;cell motility;Cell Proliferation;cell type;Cells;Cellular Stress;Destinations;Disease;Early Diagnosis;Evolution;extracellular;Extravasation;Flow Cytometry;Gene Expression;gene replacement therapy;Genetic;glial activation;Goals;Heterogeneity;Homeostasis;Hour;human disease;Image;imaging approach;Immune;immune activation;Immune response;Immunohistochemistry;improved;In Situ Hybridization;in vivo;in vivo imaging;Individual;Infiltration;Inflammatory;Invaded;Investigational Therapies;Ion Channel;Label;Lasers;life span;Light;Macrophage;Maps;Membrane;Methodology;Methods;Microglia;migration;Modeling;Molecular;Molecular Profiling;Monitor;monocyte;Nature;Nerve Degeneration;Neuronal Injury;Neurons;neuroprotection;neurotrophic factor;Phagocytosis;Phase;Phenotype;photoreceptor degeneration;Photoreceptors;Physiologic pulse;Play;Population;Population Heterogeneity;prevent;Process;programs;Proliferating;Property;protein expression;Proteins;receptor;Recovery;recruit;Research;Resolution;response;Retina;retina blood vessel structure;Retinal Degeneration;retinal imaging;Role;Schedule;Signal Transduction;single-cell RNA sequencing;stem cells;Stress;Supporting Cell;Symptoms;Techniques;Testing;Time;tissue repair;Tissues;Validation;Visual impairment;Work

PROJECT_TITLE: Microglial Activation during Photoreceptor Degeneration

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  Many human diseases are caused by genetic mutations or aberrant protein-protein interactions and challenging to treat with current drugs. This project aims to overcome a fundamental problem in drug delivery and develop a new class of drugs (i.e., intracellular biologics) to treat previously undruggable diseases.

PI_NAMEs: PEI, DEHUA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Affect;Area;Bacterial Toxins;Binding;Biological Products;Cell membrane;Cells;cellular targeting;Chemicals;Cytosol;Development;Disease;DNA Sequence Alteration;Drug Delivery Systems;Drug Targeting;Endosomes;Engineering;Enzymes;extracellular;FDA approved;G-Protein-Coupled Receptors;Genetic Diseases;Goals;Human;human disease;Human Genetics;improved;In Vitro;in vivo;Investigation;Knowledge;Mammalian Cell;Membrane;Modality;Monoclonal Antibodies;novel;novel drug class;Penetration;Peptides;Periodicity;Permeability;Pharmaceutical Preparations;Pharmacological Treatment;Population;Property;protein protein interaction;Protein Secretion;Proteins;Research;small molecule;Therapeutic;tool;tumor specificity;Tumor Tissue;uptake

PROJECT_TITLE: Development of cell-permeable peptides and proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Project Narrative: Relevance to Public Health Many mental diseases, including Alzheimer’s disease and Huntington’s disease, are thought to be caused by failures in neuronal intracellular signaling related to learning and memory. This project will improve our understanding of the operational principles of intracellular signaling in neurons and thus is expected to provide new insights into the mechanisms underlying these mental diseases and new therapeutic strategies for them.

PI_NAMEs: YASUDA, RYOHEI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Actins;Alzheimer's Disease;Animals;awake;behavioral plasticity;Brain;Cytoskeleton;Dendritic Spines;Disease;Event;Failure;genome editing;Huntington Disease;Image;Imaging Techniques;improved;innovative technologies;insight;Lead;Learning;Measures;Mediating;Membrane;Memory;Molecular;Neurons;novel therapeutic intervention;Optics;optogenetics;Pattern;postsynaptic;Process;Proteins;Psyche structure;Public Health;Shapes;Signal Pathway;Signal Transduction;Slice;spatiotemporal;Synapses;Synaptic plasticity;Technology;Time;tool;Vertebral column

PROJECT_TITLE: Neuronal Intracellular Signaling Underlying Synaptic, Circuit and Behavioral Plasticity


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Inequity in addictions and their treatment are ubiquitous threats to health and society; a global pandemic and large social movements (e.g., #BlackLivesMatter) have highlighted negative impacts of racism and discrimination for addictions and centered “structures” (e.g., policies and systems like education, housing, criminal justice, and healthcare which reinforce inequality) as the root cause of inequities, though these are grossly understudied. A new generation of addictions health services scholars trained in traditional health services and addictions content/methodology, as well as anti-racism and fields that can alter structures that reinforce inequity (e.g., policy and implementation science), is needed to address equity challenges rooted in structures. The University of Washington (UW) is a leader in addictions research, anti-racist pedagogy and research methods, policy, and implementation science and well-positioned to address the training needs of next- generation addictions scholars; thus, the UW’s Department of Health Systems and Population and Division of General Internal Medicine seek NIDA funding to found the Training in Equity and Structural Solutions in Addictions (TESSA) to prepare 11 pre- and post-doctoral scholars to be future leaders in structural solutions to inequity in addictions and their treatment via a specialized curriculum, mentored research opportunities, experience developing research career training plans, and iterative evaluation with support from both internal and external expert advisory committees.

PI_NAMEs: CHANDER, GEETANJALI ;TSUI, JUDITH ;WILLIAMS, EMILY CATERINA (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Equity;Training

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The NU-THRIVE T32 program will train postdoctoral fellows in research methods in HIV, mental health, and SGM health across the Translational Science Spectrum. Fellows will engage in a rigorous training program in which they will: 1) specialize and gain depth of knowledge in two Translational Science Skill Domains (i.e., Quantitative Methods, Qualitative Methods, Interventions & Trials, Implementation Science) through mentored research with a primary and secondary mentor; and 2) gain breadth of knowledge in all four domains through a formal training curriculum. NU-THRIVE will place fellows at the forefront of translational science in HIV and SGM health, with the ultimate goal of more rapidly moving basic science discoveries to efficacious interventions and onward toward implementation.

PI_NAMEs: NEWCOMB, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: gender minority health;HIV;Sexual and Gender Minorities;Training Programs;Translational Research

PROJECT_TITLE: Training Program in Translational Science, HIV, and Sexual and Gender Minority Health


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Approximately 20 million Americans have evidence for advanced chronic kidney disease (CKD), and more than 570,000 patients have kidney failure (end-stage kidney disease [ESKD]), the latter accounting for 7% of Medicare expenditures, approximately $35 billion. African American CKD patients in the United States are four times more likely than white patients to progress to ESRD, and variants in a single gene (APOL1) explain much of this increased risk. We propose to use cell biology, live-cell imaging, and proteomic data analysis tools to determine how the variants change APOL1’s function to cause kidney diseases.

PI_NAMEs: MADHAVAN, SETHU MADHAVAN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Accounting;Address;Affect;African American;African American population;African ancestry;Age;American;Amino Acid Sequence;APOL1 gene;Apolipoproteins;Attenuated;Autophagosome;Binding;Biochemical;bioinformatics tool;Biological;biological adaptation to stress;Biological Models;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Chronic Kidney Failure;clinically significant;Co-Immunoprecipitations;Confocal Microscopy;Cytoplasm;Cytoskeleton;cytotoxicity;Data;Data Analyses;Defect;design;Development;Diagnosis;Dialysis procedure;Disease;disease diagnosis;disease phenotype;Disease Progression;End stage renal failure;Endosomes;Event;Expenditure;experimental study;Focal and Segmental Glomerulosclerosis;Follow-Up Studies;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genotype;glomerulosclerosis;Goals;Graft Survival;High Density Lipoprotein Cholesterol;Human;human imaging;Image;Immune;immune activation;Immune System Diseases;Immunofluorescence Microscopy;Immunologic Factors;Immunologic Tests;in silico;Individual;Interferon Type II;Interleukin-1 beta;Investigation;Kidney;Kidney Diseases;Kidney Failure;knock-down;Knowledge;Lead;Learning;live cell imaging;Location;Mass Spectrum Analysis;Measures;Mediating;Medicare;Membrane Fusion;minority patient;Modeling;models and simulation;Molecular;NMR Spectroscopy;non-diabetic;novel strategies;novel therapeutic intervention;Pathogenesis;Pathologic;Pathway interactions;patient population;Patients;Pattern;Persons;Physicians;Physiological;podocyte;Population;Prevalence;Prevention;Protein Conformation;Protein Family;Proteins;Proteinuria;Proteomics;Public Health;public health relevance;Publishing;recruit;response;Risk;risk variant;Role;Scientist;Secondary to;skills;SNAP receptor;stable cell line;Stimulus;Structure;Testing;three dimensional structure;TNF gene;tool;trafficking;Transgenic Mice;United States;Variant;Vesicle

PROJECT_TITLE: Apolipoprotein L1 Interaction with SNARE Proteins in the Pathogenesis of Chronic Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PUBLIC HEALTH STATEMENT This mid-career investigator award in patient-oriented research will help establish the candidate’s mentorship and career development, allowing the candidate to investigate prodromal markers of neurodegeneration in age-related dementing disorders characterized by alpha-synuclein pathology. There is a need to identify prodromal states before patients have clinical symptoms of dementia and parkinsonism, ensuring greater likelihood that clinical interventions will modify disease progression. This research will provide important information in developing new quantitative measurements of degeneration in patients with prodromal, and clinically manifest, Lewy Body disorders, while allowing the candidate time to foster the development of mentees pursuing patient-oriented research.

PI_NAMEs: CLAASSEN, DANIEL OLIVER (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Age;age related;age related neurodegeneration;alpha synuclein;Alzheimer's disease related dementia;Anatomy;Atlases;Award;Behavior;Biodistribution;Biological;Biological Assay;biomarker development;Brain;brain abnormalities;brain iron;Brain region;Brain Stem;brain tissue;career;career development;Clinical;Clinical assessments;clinical biomarkers;clinical diagnosis;clinical investigation;Clinical Research;Complement;Contrast Media;Data;demented;Dementia;Dementia with Lewy Bodies;Deposition;design;Development;Development Plans;Diagnosis;Disease;disease model;Disease Progression;Dopamine;Early Diagnosis;Ensure;Exhibits;experience;Faculty;Fostering;Goals;Growth;high resolution imaging;high risk;Hippocampus;Human;hyposmia;Image;imaging biomarker;imaging modality;Imaging Techniques;improved;in vivo;insight;Institution;interest;Intervention;Iron;K-Series Research Career Programs;Lewy Bodies;Lewy Body Disease;locus ceruleus structure;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mentors;Mentorship;Methods;Midcareer Investigator Award in Patient-Oriented Research;motor symptom;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologist;neuromelanin;Noise;Norepinephrine;novel;Outcome;oxidation;Parkinson Disease;Parkinsonian Disorders;pars compacta;Participant;participant enrollment;Pathologic;Pathology;patient oriented research;patient population;Patients;Phenotype;Physicians;Pigments;Population;predictive modeling;Predisposition;programs;Public Health;Pure Autonomic Failures;Rare Diseases;recruit;REM Sleep Behavior Disorder;Research;Research Methodology;Research Personnel;Resolution;Resources;Risk;Scientist;Severities;sex;Signal Transduction;Spatial Distribution;Stratification;Structure;Substantia nigra structure;Symptoms;synucleinopathy;Techniques;Testing;Therapeutic;therapeutic effectiveness;Time;Tissues;Training;ultra high resolution

PROJECT_TITLE: Expanding Mentorship and Neuroimaging Expertise in Patient-Oriented Studies of Brain, Behavior, and Age-Related Dementias

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Alzheimer’s disease is the 6th leading cause of death in the United States and is expect to triple by 2050. Individuals with Alzheimer’s disease suffer from sleep disturbances and sleep disorders are associated with an increased risk for Alzheimer’s disease. Since sleep/wake cycles are a dynamic interplay between metabolism and neuronal activity, the goal of this project is to understand how changes in metabolism impact the relationship between sleep and Alzheimer’s disease and whether metabolic dysfunction is a novel therapeutic target for treating Alzheimer’s disease and sleep.

PI_NAMEs: MACAULEY-RAMBACH, SHANNON L (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acute;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;beta amyloid pathology;Biosensor;Blood Glucose;blood glucose regulation;Brain;Cause of Death;Cerebrum;Chronic;Coupled;diabetic;Electroencephalography;euglycemia;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;Goals;Hippocampus;Human;Hyperglycemia;Hypoglycemia;Impairment;Individual;Insulin Resistance;Intervention;Lead;Maintenance;Measures;Metabolic;Metabolic dysfunction;Metabolism;Metformin;Modeling;mouse model;Mus;Nerve Degeneration;neuronal metabolism;Neurons;new therapeutic target;novel;Pathogenesis;Pathology;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;preservation;prevent;Process;Production;response;restoration;Rodent Model;Role;Sleep;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Wake Cycle;synergism;tau aggregation;tau function;tau Proteins;United States;Wakefulness;Wild Type Mouse;Work

PROJECT_TITLE: The metabolic interplay of sleep and Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Narrative Due to recent advances in imaging technologies, we can “see” brain in action. My dissertation project is aimed at understanding the signals generated by one of the most widely used brain imaging technologies – functional magnetic resonance imaging – in terms of the underlying microscopic activity of brain’s neurons and communication between neurons and cerebral blood vessels. This scientific knowledge will contribute to understanding of mechanisms regulating cerebral blood flow.

PI_NAMEs: DORAN, PATRICK  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Animal Model;Animals;Anterior;Area;awake;Behavioral;Biological;Blood;Blood flow;blood oxygen level dependent;blood oxygenation level dependent imaging;blood oxygenation level dependent response;Blood Vessels;Brain;Brain imaging;brain research;Calcium;career;cell type;Cerebral cortex;Cerebrovascular Circulation;Cerebrovascular system;Communication;Complex;Conscious;constriction;contrast imaging;Data;Dependence;Development;Devices;diagnostic tool;Emotions;Engineering;experimental study;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Head;hemodynamics;Hemoglobin;Human;Image;Imaging technology;in vivo;Induced Neurons;inhibitory neuron;insight;interest;Knowledge;knowledge base;Lateral;magnetic field;Magnetic Resonance Imaging;Magnetism;Measurement;Medical Research;Microscopic;Mind;Molecular;Monitor;Motor Cortex;Mus;neural;Neurons;neuropeptide Y;Neurosciences;non-invasive imaging;optical imager;optical imaging;Optics;optogenetics;Oxygen;Pathway interactions;Pharmacology;Physiological;Population;Process;Property;Protocols documentation;Publications;receptor;Research Personnel;response;Rest;Role;sensor;Side;Signal Transduction;Signaling Molecule;Somatosensory Cortex;Stimulus;Techniques;Technology;tool;Translating;two-photon;vasoconstriction;Vasodilation;voltage;Water

PROJECT_TITLE: Simultaneous Optical Voltage Imaging and fMRI in Behaving Mice


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Kidney Disease;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Regeneration of kidney cells is an important part of recovery from many types of kidney injury but how regeneration is controlled is poorly understood. This project will study how Pax2 and Pax8, two similar proteins that are produced in kidney cells as they regenerate, control recovery after kidney injury. This project will generate a new understanding of Pax2 and Pax8 function that will help develop new therapies for kidney injury and chronic kidney disease and will provide the principle investigator with training and mentorship needed to establish an independent research career studying kidney regeneration.

PI_NAMEs: BEAMISH, JEFFREY ALAN (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Animal Model;Animals;Area;Biocompatible Materials;Bioinformatics;Biology;career;cell regeneration;Cells;Chromatin;Chronic Kidney Failure;Clinical;Clinical Skills;Complement;Complex;Data;Development;differential expression;DNA Binding;DNA Binding Domain;Educational workshop;Engineering;Ensure;Epigenetic Process;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;epithelium regeneration;experience;experimental study;Failure;Female;Genes;Genetic;Genetic Transcription;Goals;histone methyltransferase;histone modification;Homologous Protein;Impairment;Injury;Injury to Kidney;insight;Kidney;kidney cell;Kidney Diseases;Link;Measures;Mediating;Mentorship;Mitosis;Modeling;Modification;Molecular;Molecular Genetics;mosaic;Mus;mutant;Natural regeneration;Nature;nephrogenesis;Nephrology;novel diagnostics;novel therapeutics;Outcome;Pathway interactions;Patients;Phenotype;Physiology;Population;Process;programs;Proliferating;Proteins;rational design;Recovery;recruit;regenerative biology;Regenerative Medicine;Regenerative pathway;renal epithelium;Reperfusion Injury;Reporter;Research;Research Personnel;single cell analysis;Site;symposium;System;Testing;Training;Training Activity;transcriptome;Transgenic Animals;Tubular formation;Work

PROJECT_TITLE: Molecular genetic mechanisms of renal cell regeneration


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: This project will advance understanding how to breach antibiotic permeability barriers of Gram- negative pathogens during infections. Functional interactions between active efflux of antibiotics and their permeation across bacterial and host membranes will be analyzed using both empirical and computational approaches.

PI_NAMEs: ZGURSKAYA, HELEN I (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;antibiotic efflux;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Infections;Bacterial Physiology;Biophysics;Burkholderia;Bypass;Cell Communication;cell envelope;Cell membrane;Cell Physiology;Cells;Cellular Membrane;chemical property;Chemical Structure;Clinical;Data;Development;Diffusion;drug development;drug discovery;Drug Transport;efflux pump;emerging antibiotic resistance;Event;experience;Fortification;Funding;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Infection;Invaded;kinetic model;Laboratories;Link;Lipid A;Membrane;metabolomics;Methods;Modeling;Modification;Molecular;novel therapeutics;pathogen;Penetration;Permeability;Pharmaceutical Preparations;Physiological;Physiological Processes;Property;Pseudomonas aeruginosa;Pump;Research Personnel;Resistance;resistance mechanism;response;Signal Transduction;Structure;Structure-Activity Relationship;success;Testing;tool;transcriptome sequencing;uptake;virtual

PROJECT_TITLE: Permeability barriers of Gram-negative pathogens and approaches to bypass them

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Violence alters the life course of far too many adolescents and disproportionately impacts minoritized youth in neighborhoods burdened by structural inequities and high rates of community violence. Through a community- partnered cluster-randomized trial, we propose to refine and evaluate Forging Hopeful Futures, a youth empowerment intervention that combines economic justice content from job readiness training, racial and gender justice content from gender-transformative programming, and leadership building as a novel multi-level violence prevention intervention. Results expected to emerge from this rigorous effectiveness and implementation evaluation will expand our repertoire of effective interventions to address racial, and gender, and economic inequities and reduce youth violence.

PI_NAMEs: CULYBA, ALISON J. (contact)

PROJECT_TITLE: CE-22-005 Forging Hopeful Futures: A Racial and Gender-Justice Program to Reduce Youth Violence


ORG_CITY: WORCESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative This application is aimed at comparing a time-limited multicomponent linkage and treatment approach called “Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking (MISSION) to a linkage only Peer Support Intervention specifically for individuals with co-occurring substance use and mental health disorders given that they often have poor treatment engagement and other behavioral health outcomes. This study will include a 3-year, Hybrid Type 1 Randomized Controlled Trial among 208 patients that will also examine treatment mechanisms and sustainability.

PI_NAMEs: GABA, AYORKOR ;SMELSON, DAVID A (contact)

PROJECT_TITLE: Supporting Treatment Access and Recovery through Linkage and Support (STAR-LS)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Infectious Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: CD8+ T lymphocytes are essential players in mounting protective cellular immune responses against pathogenic antigens and malignantly transformed cells. The transcription factor Tcf1 has critical roles in regulating the recall response by memory CD8+ T cells and enhancing functional restoration of exhausted CD8+ T cells. The proposed studies will provide rationales for utilizing Tcf1 and its downstream pathways to promote recall response and rectify T cell exhaustion to improve viral and cancer immunity.

PI_NAMEs: XUE, HAI-HUI  (contact);ZANG, CHONGZHI

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 3-Dimensional;Acute;acute infection;Affect;antigen challenge;Antigens;ATAC-seq;BLR1 gene;cancer immunotherapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle;cell transformation;Cells;Chromatin;Chromatin Loop;Chronic;chronic infection;cofactor;Communicable Diseases;cytotoxic;cytotoxic CD8 T cells;Dissection;DNase I hypersensitive sites sequencing;Ectopic Expression;Enhancers;Environment;Epigenetic Process;exhaust;exhaustion;Exhibits;Functional disorder;functional restoration;Funding;gain of function;Generations;Genetic Transcription;Genome;Glycolysis Induction;Glycolysis Pathway;Goals;Hi-C;Histone Deacetylase;immune checkpoint blockade;Immune response;Impairment;improved;Infection;insight;Knowledge;Link;Malignant - descriptor;Malignant Neoplasms;Mature T-Lymphocyte;Memory;Modeling;Modification;Molecular;Nature;neoplastic cell;Output;pathogen;Pathogenicity;Pathway interactions;Phase;Phenotype;pre-clinical;Preventive vaccine;programs;Progress Reports;Proliferating;promoter;Research;response;Rest;Role;self-renewal;SELL gene;stem;stem cells;stemness;success;Systems Biology;T cell differentiation;T cell response;T cell transcription factor 1;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Thymocyte Development;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;tumor;Tumor Immunity;Vaccines;Viral;Virus Diseases

PROJECT_TITLE: Tcf1 programs CD8 T cell responses to enhance viral and cancer immunity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


PHR: Project Narrative Rigorous evaluation of the KATR linkage strategy has the potential to inform and enhance public health policy, such as enhancing state ATR programs to address SUD health disparities experienced by individuals in underserved areas with incomes at or below the 200% poverty level, individuals with prior criminal-justice involvement, veterans, and pregnant and parenting populations, with illicit SUD, which are all the unique characteristics of the KATR study population. As individuals with illicit SUD and these specific demographic characteristics are not unique to the geographic region of Kentucky, we believe that, if results are significant, they may be generalizable to populations with those characteristics in other states. One aspect of the KATR linkage strategy evaluation that will be crucial is determining RSS utilization and RSS combinations that are associated with long-term recovery capital and recovery maintenance success.

PI_NAMEs: BUNN, TERRY LEE (contact)

PROJECT_TITLE: RFA-CE-22-010 Evaluation of Kentucky Access to Recovery Linkage Strategy


PHR: This study will examine, via a cluster-randomized controlled trial in 20 neighborhoods with concentrated disadvantage in Pittsburgh, Pennsylvania, the effectiveness of a community resiliency collective efficacy intervention. Using a community-partnered participatory approach, this study will assess an innovative approach to address community violence by engaging community members in dialogue on child and youth thriving and consensus organizing to build collective efficacy. This will be the first rigorous evaluation of a community-designed, community-centered collective efficacy intervention intended to increase individual and neighborhood levels of collective efficacy, protective factors that are expected to reduce multiple forms of violence.

PI_NAMEs: MILLER, ELIZABETH  (contact)

PROJECT_TITLE: CE22-013 A community-centered collective efficacy intervention for prevention of community violence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Pharmacological and genetic evidence in three Alzheimer's disease (AD) mouse models suggests that the enzyme neutral sphingomyelinase 2 (nSMase2) plays a significant role in the etiology of the disease, however there are no inhibitors to test this hypothesis in clinical trials. Utilizing a high- throughput screening campaign we identified DPTIP, the first nM human nSMase inhibitor; however DPTIP has a short half- life (t1/2< 0.5h) and poor oral availability (F<5%) hampering its clinical use, and chemical modifications (~200 analogs synthesized by our group) have not led to substantial improvements. Given its significant clinical potential, we propose to synthesize and evaluate dendrimer nanoparticle conjugated-DPTIP for their ability to deliver DPTIP to brain and provide efficacy and safety in two established mouse models of AD.

PI_NAMEs: RAIS, RANA  (contact);RANGARAMANUJAM, KANNAN

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta synthesis;Address;Adrenoleukodystrophy;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;American;analog;Animal Model;Animals;arm;Biochemical;Biodistribution;Biogenesis;Biological Assay;Biological Availability;Biological Markers;Body Weight;Brain;Brain imaging;Brain Injuries;brain volume;Cells;Ceramides;Cerebrum;chemical stability;Chemicals;Chemistry;Childhood;Chronic;Circulation;Clinical;Clinical Chemistry;clinical translation;Clinical Trials;Cognition;Cognitive;cohort;Collaborations;cyanine dye 5;Data;Dendrimers;Disease;Disease Progression;Dose;drug discovery;Drug Kinetics;efficacy testing;Enzymes;esterase;Etiology;Exhibits;exosome;experience;Experimental Models;extracellular vesicles;Fluorescence Spectroscopy;Future;Generations;Genetic;Half-Life;high throughput analysis;high throughput screening;Histologic;Histology;Human;human old age (65+);Hydrolysis;Hydroxyl Radical;improved;In Vitro;in vivo;inhibitor;Kinetics;Label;Ligands;liquid chromatography mass spectrometry;Liquid substance;Mediating;Membrane;Metabolic;meter;Methods;Microglia;Minor;Modification;mouse model;multidisciplinary;Mus;N-Methylaspartate;nanoparticle;National Center for Advancing Translational Sciences;near infrared dye;neural network;Neuroglia;neuroinflammation;neuron loss;novel;novel therapeutic intervention;Oral;Oxidative Stress;Pathologic;Penetration;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase I Clinical Trials;Phenols;Plasma;Play;Production;Property;Proteins;Radial;reduce symptoms;response;RNA;Role;Safety;Senile Plaques;Signaling Molecule;Slice;Source;Sphingomyelinase;Sphingomyelins;Stimulus;Stomach;Synapses;tau Proteins;Testing;Therapeutic;therapeutic target;Time;treatment duration;Up-Regulation;uptake;vesicular release;water maze;Western Blotting;Work

PROJECT_TITLE: Dendrimer-conjugated nSMase2 inhibitor as a novel therapeutic approach for Alzheimer's Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


ORG_CITY: ATLANTA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Multifaceted strategies are needed to stem the tide of the drug overdose crisis, linking vulnerable individuals to recovery resources and helping them to build recovery capital. In this Hybrid Type 1 effectiveness-implementation trial implementing peer recovery coaches both in-person and via telemedicine at a large, urban level 1 trauma center, investigators will study the process of peer recovery coach implementation and patient- and community-oriented outcomes resulting from the program. Results will inform other EDs considering their own peer recovery coach program, including rapidly scalable telemedicine- based programs.

PI_NAMEs: CARPENTER, JOSEPH  (contact)

PROJECT_TITLE: CE-22-010 Linking Individuals Needing Care for Substance Use Disorders in Urban Emergency Departments to Peer coaches (LINCS UP)


NIH_SPENDING_CATS: Aging;Clinical Research;Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The elderly are more susceptible to an episode of acute kidney injury and subsequent development of chronic kidney disease. The purpose of this study is to explore the mechanisms underlying the decreased repair response in aging kidney after injury with a specific focus on the role of tubular senescence and decreased proliferative capacity as a possible driver of failed repair. Gaining insight into the cause for lack of reparative capacity in the aging kidney will point the way towards new therapeutic targets and interventions for this critically important clinical problem. !

PI_NAMEs: CHANG-PANESSO, MONICA  (contact)

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Advisory Committees;age group;age-related disease;aged;Aging;aging population;Alzheimer's Disease;American;Apoptosis;Atrophic;Attention;Biology of Aging;biomarker panel;career;career development;CDKN2A gene;Cell Aging;Cell Cycle Arrest;cell dedifferentiation;Cell Proliferation;Cells;Censuses;Chronic Kidney Failure;Clinical;clinically relevant;Communities;Data;Defect;Development;Elderly;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;experience;Fatal Outcome;Fibrosis;FOXM1 gene;Gene Expression Profile;Goals;human old age (65+);Impairment;In Vitro;in vivo;Incidence;injured;Injury;Injury to Kidney;insight;interest;Kidney;Knock-in Mouse;Label;Laboratories;Medical;member;Mentorship;Molecular;Morphology;Mus;Natural regeneration;Nephrology;new therapeutic target;novel;old mice;Organ;overexpression;Parkinson Disease;Pathogenesis;Persons;Phenotype;Physicians;Population;Predisposition;prevent;profibrotic cytokine;Proliferating;Recording of previous events;Recovery;Regenerative response;repaired;reparative capacity;Reporting;Repression;Resources;response;Risk;Risk Factors;Role;Scientist;senescence;senescent cell;Site;Techniques;Testing;Therapeutic Intervention;Time;Training;Training Programs;transcription factor;trend;Tubular formation;United States;Universities;Washington;World Health Organization

PROJECT_TITLE: Tubular senescence and proliferative capacity of the aging kidney


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Artemisinin-based combination therapies are the primary treatment for malaria, but rapidly evolving resistance and poor drug exposure in children with and without HIV threatens treatment efficacy. A deeper understanding of parasite and drug dynamics is needed to truly optimize treatment regimens. This proposal will leverage clinical samples from a randomized PK/PD study in HIV-uninfected and HIV-infected children to study parasite dynamics after treatment, the relationship between drug exposure and drug resistance, and the impact of HIV infection on these parameters.

PI_NAMEs: GOODWIN, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Africa;Africa South of the Sahara;Aftercare;Anti-malarials;Anti-Retroviral Agents;antiretroviral therapy;artemether;Artemisinins;asexual;benflumetol;Biological Assay;Bite;Blood;career;Cessation of life;Child;Child Development;Clinical;co-infection;Combination Drug Therapy;Combined Modality Therapy;Coupled;Data;deep sequencing;density;design;Detection;Development;Disadvantaged;Doctor of Philosophy;Dose;Drug Exposure;Drug Kinetics;Drug resistance;drug-sensitive;Early Diagnosis;efavirenz;Equilibrium;Fellowship;follow-up;Future;Genetic study;Genotype;global health;Goals;Haplotypes;Health;HIV;HIV Infections;HIV-infected adolescents;improved;in vivo;Individual;Infection;infectious disease treatment;Intervention;Investigation;Liver;Malaria;Measures;Microsatellite Repeats;Microscopic;Microscopy;Molecular;Molecular Biology;Monitor;Morbidity - disease rate;mortality;Mutation;Nature;Parasite resistance;Parasitemia;Parasites;Parents;Pathogenesis;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacology;Physicians;Population;Predisposition;Pregnant Women;Prevention;Prophylactic treatment;Randomized;randomized, clinical trials;Recurrence;recurrent infection;Regimen;Relapse;Research;Residual state;Resistance;Resolution;Risk;Risk Reduction;risk selection;RNA;Safety;Sampling;Scientist;Southeastern Asia;Techniques;Therapeutic;therapy resistant;Training;transmission process;Treatment Efficacy;treatment optimization;Treatment outcome;Treatment Protocols;Uganda;Virus Diseases

PROJECT_TITLE: High-resolution malaria parasite and drug dynamics in the context of antimalarial treatment and drug resistance selection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE (RELEVENCE) Conjunctivitis results in significant economic burden worldwide and can result in long-term vision impairment and severe systemic complications in children. This project takes advantage of international collaborations and recent advances in genomic technologies to enhance our understanding of conjunctivitis epidemics globally by identifying the pathogens involved, characterizing the evolution of pathogen genomes across time and space, and defining the immune responses to these infections. The results of this study will improve prevention methods and help to curtail spread, thus reducing the burden on cost and human ocular health.

PI_NAMEs: DOAN, THUY A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Absenteeism at work;acquired immunity;Acute contagious conjunctivitis;Address;Adenoviruses;Adult;age group;Animals;Antibiotic Resistance;Area;Azithromycin;Bacteria;Biological;care providers;Cessation of life;Child;Childhood;Clinical;co-infection;Collaborations;Conjunctivitis;Cornea;cost;Country;deep sequencing;Detection;Diagnostic;Diagnostic tests;Disease;Disease Outbreaks;Economic Burden;economic impact;Education;emerging pathogen;Epidemic;Epidemiology;Etiology;Evaluation;Evolution;Foundations;fungus;Future;future epidemic;Gastroenteritis;Gene Expression Profile;Genome;Genomics;Geographic Locations;Goals;Guidelines;Health;Healthcare;Hospitalization;Human;Immune response;improved;improved outcome;Infection;Infectious Agent;Infrastructure;International;Internet;Intervention;large datasets;Metagenomics;Methods;Molecular Diagnostic Techniques;Natural Disasters;Organism;Outcome;pathogen;pathogen genome;Pathogenesis;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pattern;Population;Population Surveillance;prevent;Prevention;Quarantine;Reporting;respiratory;respiratory distress syndrome;sample collection;Sampling;Schools;Seasons;Sentinel Surveillance;Site;Social Network;socioeconomics;Swab;targeted treatment;Technology;Time;transmission process;trend;United States;Vaccination;vaccine development;Virus;Visual impairment;Wages

PROJECT_TITLE: Seasonal Conjunctivitis Outbreak Reporting for Prevention and Improved Outcomes (SCORPIO)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE Craniofacial bone defects occur due to trauma, congenital abnormalities, and during the course of surgical treatments for stroke and cancer. Clinically-available technologies for craniofacial reconstruction are non- regenerative while current tissue engineering efforts rely on biomaterials with poor mechanical strength and in vitro expansion of stem cells that limit surgical practicality. The proposed research will develop an innovative composite biomaterial that can be used off-the-shelf, that passively promote implant integration and structural stability, and that actively accelerates biological processes that improve bone regeneration.

PI_NAMEs: HARLEY, BRENDAN A. (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Acceleration;Address;Affect;Anisotropy;Architecture;Autologous;Biocompatible Materials;Biological Process;Biophysics;Blood Vessels;bone;Bone Injury;Bone Marrow;bone morphogenetic protein receptors;Bone Regeneration;Calvaria;Clinical;Collagen;collagen scaffold;Complex;Complication;Congenital Abnormality;cost;craniofacial;craniofacial bone;cranium;Data;Defect;defined contribution;Deposition;design;Dose;Endothelial Cells;Failure;Family;Glycoproteins;Gold;healing;Histologic;Implant;improved;In Vitro;in vivo;in vivo regeneration;inhibitor;innovation;Invaded;Malignant Neoplasms;mechanical properties;Mechanics;mechanotransduction;Mesenchymal Stem Cells;Methods;millimeter;mineralization;Modeling;morphogens;Natural regeneration;Nature;Operative Surgical Procedures;Oryctolagus cuniculus;Osteoclasts;Osteogenesis;osteogenic;osteoprogenitor cell;Performance;Phenotype;Polymers;Population;Porosity;pre-clinical;Printing;Process;process improvement;Production;Proliferating;Property;prototype;Receptor Signaling;reconstruction;Reconstructive Surgical Procedures;recruit;regeneration potential;regenerative;regenerative healing;regenerative therapy;repaired;Research;sample fixation;scaffold;Shapes;Signal Transduction;stem;stem cell expansion;stem cells;stroke therapy;Structure;Technology;Time;Tissue Engineering;Trauma;Tumor necrosis factor receptor 11b;Vascular remodeling;Work

PROJECT_TITLE: Mineralized collagen composite to accelerate craniofacial bone regeneration

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Aging

PHR: Project Narrative Training the next generation of clinician-investigators in Patient-Oriented Aging Research is essential to improving care for the growing population of vulnerable older adults. Thoughtful approaches that combine the best of research training alongside close understanding of clinical issues can produce a cadre of investigators who are well-equipped to advance research in this critical area.

PI_NAMEs: SMITH, ALEXANDER KELIIMOEANU (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Geriatrics;Research Training

PROJECT_TITLE: Research Training in Geriatric Medicine


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: We will leverage our institution’s multi-disciplinary and experienced investigator base, our prior success in leading collaborative and single-site randomized clinical trials (RCTs) and mechanistic studies, and our access to a large population of urban, disadvantaged, and largely minority youth with asthma to create the District of Columbia’s Childhood Asthma in Urban Settings Clinical Research Center (DC CAUSE-CRC). It will implement network-wide research studies and conduct a highly innovative, pilot, mechanistic, non-therapeutic RCT of single-dose anti-IgE therapy (omalizumab) in the fall season in highly exacerbation-prone urban children (Omalizumab Before Onset of Exacerbations - OBOE). Over three fall seasons, OBOE will randomize at least 100 youth aged 6-17 years with persistent asthma, high levels of allergy, and a recent asthma exacerbation to omalizumab or placebo during a fall upper respiratory infection and will collect nasal secretions and blood during those infections to characterize the interaction between the host’s and microbiome’s response.

PI_NAMEs: SHEEHAN, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: aged;Allergens;Allergic;allergic response;anti-IgE;Asthma;asthma exacerbation;asthma prevention;atopy;Bacteria;base;Basic Science;Bioinformatics;Biometry;Blood;Caring;Child;Childhood Asthma;Clinical;Clinical Data;Clinical Research;Computational Biology;cost;cytokine;Data;data management;Disadvantaged;Disease;District of Columbia;Dose;Ecosystem;Epidemic;Event;experience;falls;Fostering;Future;healthy volunteer;high risk;Hour;Hypersensitivity;Immune response;Immunology;improved;Infection;Inflammatory Response;Infrastructure;inner city;innovation;Institution;Institutional Review Boards;Interferon alpha;Intervention;Investigational Drugs;Laboratories;Leadership;metatranscriptome;Microbe;microbiome;minority children;Modeling;Molecular;Moraxella;Morbidity - disease rate;multidisciplinary;multiple omics;nasal microbiome;next generation;Nose;Obesity;Observational Study;omalizumab;Oral;Outcome;Participant;participant retention;Patients;Pharmacy facility;Placebos;prevent;Production;Protocols documentation;Randomized;randomized, clinical trials;recruit;Research;Research Personnel;Research Project Grants;research study;respiratory microbiome;Respiratory Tract Infections;response;Rhinovirus;Risk;Role;Sampling;Schools;Seasons;Secure;Serum;Severities;Site;Streptococcus;Subcutaneous Injections;success;System;Time;transcriptome;transcriptome sequencing;transcriptomics;Up-Regulation;Upper Respiratory Infections;urban children;Urban Community;Urban Population;urban setting;Viral;Virus;Virus Diseases;Wheezing;Work;Youth

PROJECT_TITLE: District of Columbia Childhood Asthma in Urban Settings - Clinical Research Center


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative: The goals of this application are: 1) identify miRNA differentially expressed in amygdala and subgenual anterior cingulate cortex between subjects with BPD and matched neurotypical controls in a large discovery and replication samples of BPD (N=300 and N=100, respectively); 2) uncover the genetic mechanisms by which genome-wide significant polymorphisms from GWAS of BPD affect miRNA expression in these two brain regions; 3) test the functional effect of a selected set of miRNA in mouse models to investigate BPD-like behavioral measures.

PI_NAMEs: VLADIMIROV, VLADIMIR IVANOV (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Affect;Age of Onset;Amygdaloid structure;Anhedonia;Anterior;anti social;Anxiety;Autopsy;Behavior;behavior measurement;Behavioral;behavioral study;Bioinformatics;Biological;Bipolar Disorder;Blood Pressure;Body Temperature;Brain;Brain region;brain tissue;cingulate cortex;Clinical;cost;cost effective;Data;data integration;Data Set;design;detection platform;Diagnosis;differential expression;Disease;disorder risk;Electrocardiogram;Etiology;experience;Functional disorder;Gene Targeting;Generations;Genetic;genetic architecture;genetic association;Genetic Polymorphism;genetic variant;genome resource;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Heart Rate;Hyperactivity;Injections;Knowledge;Limbic System;Lithium;Measures;Mental Depression;Mental disorders;MicroRNAs;miRNA expression profiling;Molecular;Mood stabilizers;mouse model;Mus;Nerve Degeneration;neurobiological mechanism;Neurobiology;neuropathology;neuropsychiatric disorder;Patients;Phenotype;Physiological;Physiology;Play;Prevalence;Protocols documentation;psychiatric genomics;Public Health;Publishing;Quantitative Trait Loci;Research;Risk;risk variant;Rodent;Role;Sample Size;Sampling;Science;Secondary to;Series;severe mental illness;Signal Transduction;skills;Teenagers;Testing;transcriptome sequencing;translational approach;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: Translational Approach to Studying miRNA functions in sACC and amygdala in patients with BPD

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal is aimed to determine if a systems geroscience approach can be leveraged to identify potential synergy among age-delaying strategies, which when given alone, can delay pathology and symptoms in mouse models of AD. As such, we will use several approaches to characterize established and emerging strategies on major aging pillars, including proteostasis, inflammation, metabolism, and macromolecular damage in relevant brain regions, along with omics datasets to build a systems view of aging pillars and AD. Based upon these data, we will use our systems approach to predict possible synergistic effects in silico among these strategies and this model will then be validated in vivo as compared to controls and each intervention alone, thereby demonstrating the potential utility of systems geroscience to identify novel treatment strategies for AD.

PI_NAMEs: HUFFMAN, DEREK MAJOR (contact);TU, ZHIDONG

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Age;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloidosis;Animals;Appearance;Biological Aging;Biological Models;Blood;Brain region;burden of illness;Caloric Restriction;Chronic Disease;Cognition;combinatorial;comparative;comparison control;Complex;Data;Data Set;design;Disease;Disease Progression;Etiology;Exercise;Female;Formulation;gene network;gene regulatory network;Genes;Genomics;geroprotector;Geroscience;hallmarks of aging;healthspan;Hippocampus;Histone Deacetylase Inhibitor;human disease;improved;in silico;in vivo;in vivo evaluation;Inflammation;Insulin-Like Growth Factor I;Intermittent fasting;Intervention;Late Onset Alzheimer Disease;life span;male;Metabolism;Modeling;mouse model;multiscale data;Mus;novel;Onset of illness;Pathology;Pathway Analysis;Pathway interactions;Peripheral;Phenotype;Plasma;Pre-Clinical Model;Prefrontal Cortex;presenilin-1;preservation;prevent;Probability;proteostasis;rate of aging;Regulatory Pathway;response;Risk Factors;Sex Differences;Signal Transduction;Sirolimus;Spermidine;Support System;Symptoms;synergism;System;Systems Analysis;Tauopathies;Testing;Tissues;transcriptome sequencing;transcriptomics;Translating;treatment strategy;Validation

PROJECT_TITLE: A systems approach for identifying geroprotector synergy in Alzheimer’s disease


ORG_DEPT: BIOCHEMISTRY

PHR: Public Health Relevancy Statement/Project Narrative Lifestyle and career changes in the Western world have lead to couples putting off childbearing until later in life. Not only is time to conception delayed in older men, but it is increasingly clear that children of older men are at increased risk for certain neurodevelopmental diseases. Here, we propose to thorouhgly investigate the effects of advanced age on the male reproductive tract, focusing not only on the testis but also on understudied male reproductive tissues of relevance to fertility including the epididymis and seminal vesicle. We will also investigate changes in behavior and metabolism in offspring of older males, and will characterize the changes in the sperm epigenome that might explain these changes. These studies will be of great importance for understanding how male reproductive function changes with age.

PI_NAMEs: RANDO, OLIVER J (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Address;Adult;Affect;age effect;Age Months;age related changes;Aging;aging process;animal old age;Animals;Behavior;Behavioral;behavioral phenotyping;Caloric Restriction;career;Cell Physiology;cell type;Cells;Child;child bearing;Conceptions;Country;Couples;Cytosine;Data Set;Development;Disease;disorder risk;Elderly;Epididymis;Epigenetic Process;epigenome;epigenomics;experimental study;father role;Female;Fertility;Follow-Up Studies;Foundations;Future;Future Generations;Genes;Genetic Transcription;genome-wide analysis;genomic platform;Germ Lines;Goals;Health;Histologic;Histones;Human;Inbred Mouse;Individual;innovation;Intervention;juvenile animal;Lead;Life;Life Style;male;Measurement;Metabolic;metabolic phenotype;Metabolism;Methylation;Modeling;Molecular;Mouse Strains;Mus;Mutation;neurodevelopment;Neurodevelopmental Disorder;neuropsychiatric disorder;next generation;offspring;older men;Partner in relationship;Paternal Age;Phenotype;Population;Pre-implantation Embryo Development;Prevalence;Prostate;Public Health;reproductive;Reproductive Biology;reproductive function;reproductive tract;Resolution;Risk;RNA;Seminal Vesicles;single cell genomics;single-cell RNA sequencing;sperm cell;Surveys;Testis;Therapeutic;Time;Tissues;trait;transcriptome sequencing;transmission process;United States;Western World;zygote

PROJECT_TITLE: Effects of paternal aging on male reproductive biology and on future generations

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_NAME: DNASTAR, INC.

ORG_STATE: WI

PHR: Antibodies are invaluable biotechnology tools for diagnosing and treating human diseases; they have been used to detect drugs, toxins, hormones, or pathogens; perform tissue typing; suppress organ transplant rejection; and therapeutically treat viral infections, cancer, and autoimmune diseases. In this project, we will develop a pipeline to replace a large portion of costly, time-consuming experimental work required today in antibody drug discovery with a software pipeline based on improvement in and integration of protein structure prediction, protein-protein docking and protein engineering tools we currently provide to the market. Our proposed pipeline will be poised to accelerate antibody drug development and reduce costs of antibody drug discovery by 80 – 90%, literally revolutionizing the way antibody discovery and development is performed by biotech and pharmaceutical companies and third-party contract research organizations.

PI_NAMEs: BLATTNER, FREDERICK R (contact);LANDRY, CHARLES F

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Affinity;Algebra;algorithm development;Algorithms;Antibodies;Antibody Affinity;Antibody Binding Sites;Antigen Targeting;Antigen-Antibody Complex;Antigens;Artificial Intelligence;Autoimmune Diseases;Avidity;B-Lymphocyte Epitopes;Binding;Bioinformatics;Biotechnology;blind;Carrier Proteins;Charge;Chemicals;Chinese Hamster Ovary Cell;Client;Cloud Computing;complex modeling;Computer Assisted;Computer software;Consumption;cost;Critiques;cross reacting material 197;Data;design;Detection;Development;Diagnosis;Disease;Dissociation;DNA;Docking;drug development;drug discovery;Drug Industry;drug testing;Epitopes;Event;experimental study;flexibility;G-Protein-Coupled Receptors;Genetic Recombination;Germ Lines;Goals;Health;high throughput screening;Histocompatibility Testing;Hormones;Human;human disease;Immune system;Immunoglobulin Fragments;improved;in silico;In Vitro;Individual;Interferometry;kinematics;Kinetics;Laboratories;Libraries;Malignant Neoplasms;Marketing;mathematical methods;Mathematics;Measures;mechanical force;Medical;Methods;Minor;Modeling;Molecular;Molecular Conformation;molecular mechanics;Monoclonal Antibodies;Mutation;nanomolar;novel therapeutics;organ transplant rejection;Parents;particle;pathogen;Pharmacologic Substance;Phase;Physics;predictive modeling;Process;Property;Protein Engineering;Protein Region;protein structure prediction;Proteins;Recording of previous events;Research Contracts;Research Personnel;response;Running;SARS-CoV-2 spike protein;screening;Screening Result;Services;Shapes;simulation;Site;Specificity;Speed;Structure;success;Surface;System;Techniques;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Time;tool;Toxin;Training;Translating;Variant;virtual;virtual screening;Virus Diseases;Visualization;wasting;Western Blotting;Work

PROJECT_TITLE: Rapid structure-based software to enhance antibody affinity and developability for high-throughput screening: Aiming toward total in silico design of antibodies


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Orphan Drug;Patient Safety;Prevention;Rare Diseases

ORG_CITY: Columbia

ORG_NAME: INTRALYTIX, INC.

PHR: PROJECT NARRATIVE We anticipate that our novel phage-based preparation (ShigActive™) will reduce the risk of diseases due to consuming foods or water contaminated with Shigella spp. This approach is expected to have a significant positive public health impact in reducing worldwide morbidity and mortality due to Shigella infections of which there are ~125 million worldwide cases of shigellosis and ~14,000 deaths annually, the majority in children under the age of 5. Moreover, success of our studies is likely to lead to the development of other phage-based products for many other gastrointestinal diseases of bacterial etiology, including those having epidemic potential (e.g., cholera).

PI_NAMEs: CHEN, WILBUR H.;FRASER, CLAIRE M.;KOTLOFF, KAREN L.;SULAKVELIDZE, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Age;Antibiotic Resistance;Antibiotics;Bacterial Infections;Bacteriophages;beneficial microorganism;Bioinformatics;Biological Products;Blood;Cessation of life;Child;Cholera;Clinical;clinical application;Clinical Trials;Communicable Diseases;contaminated water;Control Groups;Cyclic GMP;Data;data management;Death Rate;Developing Countries;Development;Development Plans;Diarrhea;Diarrheagenic E. coli;Digestive System Disorders;Disease;Disease Outbreaks;disorder risk;Dose;Double-Blind Method;efficacy evaluation;efficacy trial;Ensure;enteric pathogen;epidemic potential;Etiology;Evaluation;FDA approved;fecal microbiome;Feces;Fever;follow-up;Food;food consumption;Food Contamination;Gastrointestinal Agents;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;Good Clinical Practice;Guidelines;gut microbiota;Human;human morbidity;human mortality;Incidence;Infection;innovation;Inpatients;Institutional Review Boards;Lactoferrin;Legal;Lytic;manufacture;Maryland;Measures;Medical;Medical center;medical schools;microbiome;microbiota;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;Mucosal Immune Responses;Nausea;New York;next generation sequencing;novel;Oral Administration;Outpatients;pathogenic bacteria;Phase;phase I trial;Placebo Control;Placebos;pre-Investigational New Drug meeting;Preparation;Prevalence;prevent;Process;Protocols documentation;Public Health;Randomized;Regulation;Research;resistant Shigella;resistant strain;Resources;Risk Reduction;Safety;safety assessment;Series;Serious Adverse Event;Severities;Sexual Transmission;Shigella;Shigella flexneri;Shigella Infections;Signs and Symptoms;success;Techniques;technology platform;tool;Treatment Protocols;Universities;vaccine development;Vaccines;Vibrio cholerae

PROJECT_TITLE: Bacteriophage-based approach for managing Shigella infections


NIH_SPENDING_CATS: Asthma;Genetics;Lung;Nutrition

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Failure of Treg cell function in suppressing TH2 responses correlates with the onset and progression of allergic airway disease. In this application, we aim to elucidate the fundamental mechanisms by which Treg cells integrate immune signaling and cellular metabolism to ensure Treg cell function in preventing allergic airway inflammation. Insights gained from this application may manifest therapeutic opportunities for the treatment of allergic airway disease.

PI_NAMEs: YANG, KAI  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;Adoptive Immunotherapy;Affect;Airway Disease;airway hyperresponsiveness;Allergic;allergic airway disease;allergic airway inflammation;Allergic inflammation;allergic response;American;Anabolism;Antigens;Asthma;CD4 Positive T Lymphocytes;Cell Physiology;Cell Reprogramming;Cells;Cellular Metabolic Process;Chronic;cytokine;Cytoplasm;Development;Disease;Economic Burden;Ensure;enzyme biosynthesis;Enzymes;eosinophil;Failure;fatty acid biosynthesis;fatty acid metabolism;fatty acid oxidation;FOXP3 gene;Functional disorder;Genetic Transcription;Health;Homeostasis;IgE;Immune signaling;Immune System Diseases;Immunity;Impairment;improved;Infiltration;Inflammation;Inflammatory;insight;IRF4 gene;Link;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Lung;Mediating;Membrane;Metabolic;Metabolism;mouse model;Mus;Nuclear;Nuclear Translocation;Nutrient;Pathway interactions;Physiological;Predisposition;Prevalence;prevent;Process;Production;programs;Proliferating;Pulmonary Inflammation;Pyroglyphidae;receptor;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;response;restraint;Role;Signal Pathway;Signal Transduction;Specific qualifier value;STK11 gene;T-Lymphocyte;Testing;Th2 Cells;Therapeutic;therapeutic target;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;Triglycerides;Unsaturated Fatty Acids

PROJECT_TITLE: Transcriptional and metabolic regulation of Treg cell specification for the control of allergic airway disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE The human microbiome is known to regulate host immune system function, but the mechanisms underlying this relationship are incompletely understood. This proposal will identify causal associations between microbial derived metabolites and human immune system function in health, autoimmunity, allergy, and infectious disease. Uncovering these host-microbiome circuits may inform the development of therapeutics to treat immune-mediated disease.

PI_NAMEs: GRAHAM, DANIEL BARTHOLOMEW;XAVIER, RAMNIK J (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Agonist;Allergic Disease;Anatomy;Antigen Receptors;Antigens;Autoimmune;Autoimmune Diseases;Autoimmunity;cell behavior;Cell Differentiation process;Cells;Chemicals;commensal microbes;Communicable Diseases;conditioning;Consensus;Cues;cytokine;Dendritic Cells;desensitization;Digestion;Disease;Ecosystem;Epigenetic Process;Epithelium;Evolution;Exposure to;Fractionation;G-Protein-Coupled Receptors;Gene Cluster;Genetic;Glycolipids;GPR35 gene;Health;host microbiome;Human;Human Microbiome;Hypersensitivity;Immune;immune function;Immune response;immune system function;Immunity;Immunologic Receptors;immunoregulation;Inflammatory;innate immune pathways;Innate Immune Response;innovation;Libraries;Ligands;Lymphocyte;Machine Learning;Maps;Mediating;Metabolic;Metagenomics;Microbe;microbial;microbiome;Molecular;Nature;novel;Nutrient;pathogen;Pathology;Pathway interactions;Patients;peripheral tolerance;Physiological;receptor;Reporter;resilience;response;Role;Shapes;Signal Transduction;small molecule;Symbiosis;T cell differentiation;therapeutic development;Training;transmission process;uptake;Xenobiotics

PROJECT_TITLE: Identification and Characterization of Microbial Metabolites in Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(57)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: PROJECT NARRATIVE There is ample evidence that parental substance use is a significant risk factor for adolescent substance use and there are a number of potential parenting-related mediators which explain this relationship. This study will advance our understanding of the intergenerational transmission of substance use through novel methodological developments which support the use of multiple informant data in statistical mediation analyses. Findings have the potential to contribute to developmental theory as well as family-based preventive interventions.

PI_NAMEs: GEORGESON, ALEXIS RAE (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Address;Adolescent;adolescent alcohol and drug use;adolescent substance use;Alcohol consumption;Behavior;Behavior assessment;Behavior monitoring;Child Rearing;Complex;Data;Data Set;design;Development;Discipline;Drug usage;Evaluation Methodology;Failure;Family;Fellowship;Generations;improved;Individual;informant;intergenerational;Intervention;Measurement;Measures;Mediating;Mediation;Mediator;Methodology;Methods;Modeling;Monitor;National Institute of Drug Abuse;National Research Service Awards;novel;Outcome;Parameter Estimation;parental monitoring;parental role;Parents;Performance;Prevention;Prevention program;preventive intervention;Procedures;Process;programs;Psychometrics;Reporter;Reporting;Research;research data dissemination;Research Personnel;response;Risk;Risk Factors;Role;Science;Scoring Method;simulation;Source;substance use;Testing;theories;Training;transmission process;Work

PROJECT_TITLE: Advancing measurement and scoring methods for testing mediation models of substance use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Sepsis;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHARLESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The goals of our research program are to gain a deep understanding of the mechanisms behind pericyte activation, subsequent pericyte loss, and their impact on cerebrovascular dysfunction in sepsis-induced cognitive impairment and to develop novel targeted treatment to sepsis-associated encephalopathies.

PI_NAMEs: FAN, HONGKUAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Animal Model;Antisense Oligonucleotides;Apoptosis;Autopsy;Blood - brain barrier anatomy;Blood Vessels;Brain;brain pericytes;brain tissue;CASP1 gene;Cells;Cerebrovascular Circulation;Cerebrovascular Disorders;comparison control;Cytometry;Development;Encephalopathies;Exhibits;Extravasation;FLI1 gene;FLI1 Transcription Factor;Goals;Hippocampus;Image;Impaired cognition;Impaired health;improved;Inflammation Mediators;Inflammatory;Knockout Mice;Laboratories;Memory impairment;Mental Health;monocyte;Mus;neuroinflammation;Neuronal Dysfunction;neurovascular unit;novel;Pathologic;Patients;Pericytes;Persons;Play;Production;programs;recruit;Reporting;Research;response;Role;Sepsis;septic patients;single nucleus RNA-sequencing;Survivors;targeted treatment;treatment strategy;Vascular Cognitive Impairment;Vascular Diseases

PROJECT_TITLE: The Role of Pericytes in the Vascular Dysfunction of Sepsis


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Crisis stabilization centers (CSCs) provide a less costly and more comfortable alternative to Emergency Department care for individuals with acute suicidal crises. With demand for crisis alternatives growing, effective interventions designed and tested for CSCs are urgently needed to realize their life-saving potential. This study adapts and tests the effectiveness of a crisis recovery and follow-up intervention that seeks to reduce suicide risk by strengthening interpersonal connections.

PI_NAMEs: LOCKMAN, JENNIFER ;PISANI, ANTHONY R (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Adherence;Administrator;Ambulatory Care;Caring;Cessation of life;Client;Code;cohort;Communities;cost;Data;design;effective intervention;effectiveness testing;effectiveness trial;Emergency Care;feasibility testing;Feeling suicidal;follow-up;Funding;Growth;Health Services Accessibility;Healthcare;hospital readmission;Human Resources;Individual;Inpatients;Intervention;intervention delivery;intervention effect;Investments;Life;Light;Mainstreaming;Manuals;Mental Health;Modeling;novel;Patients;Philosophy;pilot test;pilot trial;Psychiatric therapeutic procedure;Psychological reinforcement;psychosocial;Randomized;randomized trial;Recovery;reducing suicide;Research;Resources;Safety;satisfaction;Services;social;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Telephone;telephone coaching;Testing;Text;theories;therapy design;Training;trial readiness

PROJECT_TITLE: Pilot Effectiveness Trial of THRIVE in Crisis Stabilization Centers: Promoting Connection, Recovery, and Treatment Linkage after Suicide Crisis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The studies proposed in this project will elucidate the molecular mechanisms underlying the action of the gaseous signaling molecule, hydrogen sulfide, in the brain during normal conditions and in Alzheimer's disease. Signaling pathways regulated by hydrogen sulfide, which confer neuroprotection will be identified with a view to develop novel therapeutics for Alzheimer's disease.

PI_NAMEs: PAUL, BINDU  (contact)

PROJECT_TERMS: 3-Mercaptopyruvate sulfurtransferase;3xTg-AD mouse;Affect;Age;age related neurodegeneration;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amino Acids;Antioxidants;Behavior;behavior test;biological adaptation to stress;Biological Assay;biomarker development;Brain;Brain region;Cell Line;Cell Physiology;Cells;Central Nervous System;Cystathionine;Cystathionine beta-Synthase;Cysteine;Cysteine Desulfhydrase;Cysteine Metabolism Pathway;Development;dimedone;Disease;enzyme activity;Enzymes;Equilibrium;Generations;Glutathione;Goals;Hippocampus;Huntington Disease;Hydrogen Sulfide;Immunohistochemistry;Impairment;Inflammation;interest;Learning;Lyase;Maintenance;Maps;Mediating;Memory;Metabolism;Methods;Mitochondria;Modification;Molecular;Monitor;Motor;mouse model;multidisciplinary;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;neurotransmission;Nitric Oxide;novel therapeutics;nuclear factor-erythroid 2;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Pathology;Pathway interactions;Physiological;Physiological Processes;Post-Translational Protein Processing;Precision therapeutics;prevent;Prodrugs;Production;Proteins;Regulation;Research Personnel;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;SKIL gene;sulfhydration;Supplementation;Testing;therapeutic target;Wild Type Mouse

PROJECT_TITLE: Neuroprotective actions of cystathionine g-lyase through gasotransmitter hydrogen sulfide signaling

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

PHR: Narrative We propose a study of whether certain neurodevelopmental disorders – autism, attention-deficit hyperactive disorder, and intellectual disability – may increase risk of later life neurodegenerative disorders such as dementia, Parkinson’s disease, and amyotrophic lateral sclerosis. This study will generate knowledge critical to understanding aging in persons with neurodevelopmental disorders.

PI_NAMEs: LEE, BRIAN KANE (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Affect;age acceleration;Age of Onset;Aging;aging clocks;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyotrophic Lateral Sclerosis;Attention deficit hyperactivity disorder;autism spectrum disorder;biobank;Brain region;burden of illness;Cardiometabolic Disease;Cessation of life;Child;cognitive function;cognitive reserve;cohort;Country;Data;Dementia;dementia risk;Denmark;Development;Disease;Epidemiology;epidemiology study;epigenetic clock;Family;Family history of;follow-up;General Population;Genes;Genetic;genome wide association study;Genotype;hazard;high risk;human old age (65+);individuals with autism spectrum disorder;Intellectual functioning disability;Intervention;Knowledge;late life;Link;Mediator;Mendelian randomization;Molecular;mortality;Natural History;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurodevelopmental effect;older adult;Onset of illness;Parkinson Disease;Persons;Phenotype;Physical activity;Physical Function;polygenic risk score;Population;Prevalence;Process;Prospective cohort;Recording of previous events;Risk;Risk Factors;risk mitigation;Sweden;Tissues

PROJECT_TITLE: LEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders Study


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The objectives of this study are to: (1) determine the individual- and neighborhood-level outcomes associated with implementation of overdose prevention centers (OPCs) in New York City and Rhode Island; and (2) to examine the role that the local context, including neighborhood, program models, operating procedures and costs, play in shaping the impact of OPCs. This research will provide urgently needed evidence on the potential benefits and unintended consequences of a novel harm reduction strategy to address the overdose crisis in the United States.

PI_NAMEs: CERDA, MAGDALENA  (contact);MARSHALL, BRANDON DAVID LEWIS

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Accident and Emergency department;Accidents;Acute;Address;Affect;Authorization documentation;Businesses;Censuses;Cities;Client;Clinic;cohort;Communities;community center;community engaged research;comparative;Consumption;Control Groups;cost;cost effectiveness;Cost Effectiveness Analysis;Cost Savings;Country;Criminal Justice;Data;Data Set;Data Sources;Disease;drug market;Drug usage;Drug user;Economic Conditions;Economics;Education;Effectiveness;effectiveness study;Environment;ethnographic method;Ethnography;Evaluation;Event;Evidence based treatment;experience;Fatality rate;Future;Harm Reduction;Health;Health Priorities;Health Services;Healthcare;Hepatitis C;HIV;Hospitals;Human Resources;improved;Individual;Infective endocarditis;innovation;International;Intervention;Interview;Legal;Link;Location;Measures;Medicaid;Medical;Methods;microcosting;Modeling;models and simulation;mortality;multidisciplinary;Municipal Government;Needle Sharing;Needle-Exchange Programs;Neighborhoods;New York City;Noise;novel;Outcome;Outcome Measure;Overdose;overdose death;overdose prevention;Participant;peer;Persons;Pharmaceutical Preparations;Physical environment;Play;Police;Policies;Prevention program;Procedures;Program Effectiveness;programs;Property;prospective;Prospective cohort;Public Health;public health emergency;Qualitative Methods;Records;recovery services;referral services;Research;response;Rhode Island;Risk;Role;Safety;Service delivery model;Services;Shapes;Site;Skin Tissue;social;Social Identification;Social Policies;Social Work;Soft Tissue Infections;Statutes and Laws;Sterility;Substance Use Disorder;Supervision;System;Time;Training;treatment services;United States;United States Dept. of Health and Human Services

PROJECT_TITLE: A comparative evaluation of overdose prevention programs in New York City and Rhode Island


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Vascular surgery is expected to see a workforce shortfall in the future. This T35 program will expose medical students to vascular surgery and the research that informs it. The aim is to meet the needs of our aging population, satisfying the strategic vision of NHLBI including understanding human biology, reducing human disease, developing workforce and resources, and advancing translational research.

PI_NAMEs: SACHDEV, ULKA  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: aging population;Biological Process;Biology;Biomedical Engineering;Blood;Blood Vessels;Cardiology;Career Choice;Clinical;clinical conference;Clinical Research;Data Science;Development;Disease;Education;experience;Exposure to;Faculty;frontier;Funding;Future;Goals;Health;health difference;Heart;Human Biology;human disease;implementation research;improved;Individual Differences;Institute of Medicine (U.S.);Laboratory Research;lectures;Lung;Manuscripts;medical schools;Medical Students;Medicine;Mentors;Mentorship;Mission;National Heart, Lung, and Blood Institute;novel diagnostics;novel therapeutic intervention;Operative Surgical Procedures;Outcomes Research;Population;prevent;programs;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Research Project Grants;resilience;Resources;Sleep;Strategic vision;Students;summer research;Translational Research;Travel;treatment response;Universities;Vascular Diseases;Work

PROJECT_TITLE: Summer Research in Vascular Surgery (SRVS)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The majority of patients with neuroendocrine tumors (NETs) ultimately die from metastatic disease due to the lack of effective therapies, necessitating a better understanding of mechanisms promoting NET progression and metastasis to guide the development of improved targeted treatments. Proposed studies test our hypothesis that the RABL6A-PP2A pathway is a critical driver of NET progression (including metastasis) and response to targeted therapies. This work addresses a major gap in NET research, builds upon an emerging anticancer strategy of pharmacological reactivation of PP2A, and may have broad cancer relevance beyond NETs given the importance of RABL6A and PP2A in other tumor types.

PI_NAMEs: NARLA, GOUTHAM ;QUELLE, DAWN E (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;advanced disease;Affect;angiogenesis;anti-cancer;Automobile Driving;c-myc Genes;cancer therapy;Cell Cycle;Cell model;Cell Proliferation;Cell Survival;Clinical;Combined Modality Therapy;Data;Dependence;Development;Disease;effective therapy;efficacy evaluation;Event;experimental study;FRAP1 gene;Genetic;Growth;Guanosine Triphosphate Phosphohydrolases;Half-Life;Holoenzymes;Human;improved;In Vitro;in vivo;Incidence;inhibitor;insight;Invaded;Islet Cell Tumor;Knowledge;Malignant Neoplasms;Measures;migration;Molecular;Molecular Analysis;mouse model;mTOR Inhibitor;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Tumors;novel strategies;novel therapeutics;Oncogenic;Oncoproteins;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phase;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Population;Progression-Free Survivals;Proliferating;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;RB1 gene;Receptor Protein-Tyrosine Kinases;Regulation;Research;Resources;response;Role;Signal Transduction;small molecule;targeted treatment;Testing;Therapeutic;tumor;Tumor Cell Migration;tumor growth;tumor progression;Tumor Suppressor Proteins;Validation;Work

PROJECT_TITLE: Role of RABL6A-PP2A in neuroendocrine tumors

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Substance use disorders remain a pressing problem in this country and the interdisciplinary training program proposed here address that problem by preparing individuals with the skills necessary to advance knowledge of the behavioral, neurobiological and pharmacological effects of drug and alcohol abuse. This knowledge is central to the development of treatments for those who are suffering from substance use disorders and for the prevention of this disease in others.

PI_NAMEs: CARELLI, REGINA M (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: addiction;pre-doctoral;Science;Training

PROJECT_TITLE: Predoctoral Training in Addiction Science


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Prevention;Skin Cancer

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: NARRATIVE Nonmelanoma skin cancer, which includes squamous cell carcinoma (SCC), is the most common cancer diagnosed in the United States. SCC usually develop from premalignant precursors, providing an opportunity for intervention to prevent malignant disease and metastatic progression. This research will delineate aberrant prosurvival signaling pathways in skin cancer cells in order to develop candidate agents to disrupt this signaling. Successful completion of this work is anticipated to lead to novel approaches for the prevention and treatment of skin cancer.

PI_NAMEs: HANSEN, LAURA A (contact)

PROGRAM_OFFICER_NAME: PARNES, HOWARD L

PROJECT_TERMS: Actinic keratosis;anti-cancer;Apoptosis;Apoptotic;Benign;Binding;cancer cell;cancer diagnosis;Cancer Model;cancer therapy;Carrier Proteins;CDC25A gene;Cell Death Induction;cell killing;Cell Nucleus;Cells;Cessation of life;Client;Clinical Treatment;Clinical Trials;Cytoplasm;Data;Death Rate;Dependence;design;Development;Dimerization;Disease;Dose;efficacy evaluation;Excision;experimental study;Exportins;Gene Deletion;Genes;Genetic;Growth;Health Care Costs;Heterodimerization;Human;Immunocompromised Host;immunosuppressed;improved;in silico;Incidence;inhibitor;Intervention;Investigation;Knockout Mice;Lead;Lesion;Libraries;Malignant - descriptor;Malignant Epithelial Cell;Malignant Keratinocyte;Malignant Neoplasms;Malignant Squamous Cell;Metastatic/Recurrent;Minor;molecular dynamics;Mus;novel;novel strategies;Nuclear;nucleocytoplasmic transport;Oncogenic;Operative Surgical Procedures;organ transplant recipient;overexpression;Pathway interactions;Patients;Penetration;Peptides;Population;premalignant;prevent;Prevention;Prevention approach;Procedures;Proteins;Proto-Oncogene Proteins c-akt;PTPRJ gene;Regulation;Research;Scaffolding Protein;side effect;Signal Pathway;Signal Transduction;Signaling Protein;Skin;Skin Cancer;skin cancer prevention;Skin Carcinogenesis;Skin Carcinoma;Skin Neoplasms;Solid;Squamous cell carcinoma;Survival Rate;survivin;targeted agent;Testing;Toxic effect;Translating;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;ultraviolet;ultraviolet irradiation;United States;UV Radiation Exposure;Work;Xenograft procedure

PROJECT_TITLE: Targeting aberrant anti-apoptotic signaling for prevention of skin cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Narrative The high prevalence of alcohol use disorders (AUD) and other mental disorders causes severe socioeconomic stress for patients, families, and society. Despite identifying many genetic risk factors from human studies, effective therapeutics are limited due to a lack of understanding of the AUD pathophysiology. This proposal aims to understand neuroimmune interactions in a human neural model and examine how ethanol and individual (poly)genetic background affects these interactions; therefore, results derived from this study will guide the development of novel therapeutics for AUD.

PI_NAMEs: PANG, ZHIPING P. (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;alcohol effect;alcohol exposure;alcohol use disorder;Architecture;Astrocytes;ATAC-seq;Behavior;Biochemistry;Biological Models;Brain;Brain Diseases;cell type;Cells;Characteristics;Chromatin;Chronic;Coculture Techniques;Code;Collection;Communities;Complex;cytokine;Data;data integration;Development;disorder risk;Electrophysiology (science);Environmental Risk Factor;Epigenetic Process;Ethanol;Family;Foundations;Functional disorder;functional genomics;Funding;Gene Expression;gene network;Genes;Genetic;genetic makeup;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome-wide analysis;genomic data;Genomics;High Prevalence;Human;Human Genetics;human induced pluripotent stem cells;Image;Impairment;In Vitro;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Inflammasome;insight;Knowledge;Link;live cell imaging;Measures;Mediating;Mental disorders;Microglia;Minor;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;Mus;Nature;neural;neural circuit;neural model;neurogenesis;Neuroglia;Neuroimmune;neuroinflammation;Neurons;neuropsychiatric disorder;novel therapeutics;Opioid;Organoids;Pathogenicity;Pathway interactions;Patients;Phenotype;polygenic risk score;Process;Proteins;Reproducibility;Research;Resolution;Resources;response;Risk;risk variant;Role;sex;single-cell RNA sequencing;Societies;socioeconomics;stem;Stress;Study models;synaptic function;Synaptic Transmission;System;Testing;therapeutically effective;transcriptomics;Untranslated RNA;Variant

PROJECT_TITLE: Cellular and genomic mechanisms of the impact of ethanol on human neural model

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Spinal cord injury is a leading cause of paralysis in the United States with limited treatment options. Astrocytes influence injury outcome after spinal cord injury and therefore present an attractive cellular target for repair strategies. This proposed research will determine location specific functions of reactive astrocytes in the injured spinal cord to provide the basis for an astrocyte-targeted approach to promote neural recovery and reduce human disability.

PI_NAMEs: CHEN, MEIFAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Abbreviations;Area;Astrocytes;astrogliosis;Attenuated;Axon;axon growth;axonal degeneration;axonal sprouting;Cells;cellular targeting;central nervous system injury;Chest;Chronic;Cicatrix;Corticospinal Tracts;Data;Diffuse;disability;Distal;Functional disorder;Genetic;genetic manipulation;Glial Fibrillary Acidic Protein;Goals;Hindlimb;Human;in vivo;Injury;injury and repair;injury recovery;insight;Knock-out;Knowledge;Lateral;Lesion;Leucine Zippers;Location;Macrophage;Macrophage Colony-Stimulating Factor;Maintenance;Mediating;Microglia;Microinjections;Modeling;Molecular;monocyte;Motor;Mus;neural;neural repair;novel;Outcome;overexpression;Paralysed;Pathologic;Pathology;Pathway interactions;Phenotype;Phosphotransferases;Primary Lesion;Proliferating;promoter;Reaction;Recovery;Regulation;repair strategy;repaired;Repression;Research;response to injury;restoration;Role;Sensory;Site;Spinal;Spinal Cord;Spinal cord injury;spinal cord repair;Tamoxifen;targeted treatment;Testing;Therapeutic;Tissues;tool;Translating;translational approach;Traumatic CNS injury;United States;Work

PROJECT_TITLE: Functional Diversity of Reactive Astrocytes in Spinal Cord Repair

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative We aim to develop highly effective AAV vectors for noninvasive gene delivery to the nervous system and to validate their use for treating CNS injuries in adult mammals.

PI_NAMEs: LI, SHUXIN  (contact)

PROJECT_TERMS: adeno-associated viral vector;Adult;Age;age related decline;Alzheimer's Disease;Astrocytes;Axon;axon growth;axon regeneration;Biomedical Engineering;Blood - brain barrier anatomy;blood-brain barrier crossing;c-myc Genes;Capsid;Capsid Proteins;Cd68;Cells;cellular transduction;Central Nervous System Diseases;central nervous system injury;Chimeric Proteins;Chondroitin Sulfate Proteoglycan;Cicatrix;Clinical;design;effective therapy;Effectiveness;Engineering;Evaluation;Failure;Gene Delivery;Gene Targeting;Genes;Glial Fibrillary Acidic Protein;Growth;Growth Inhibitors;improved;in vivo;Induced Neurons;inhibitor;Injections;Intravenous;intravenous injection;Invaded;Locomotor Recovery;Mammals;Mediating;Microglia;MicroRNAs;Molecular Target;Motor;Mouse Strains;Mus;Mutagenesis;Natural regeneration;Nervous System;Nervous System Disorder;Nervous System Trauma;neural;neuronal growth;Neurons;Neurosciences;Neurosciences Research;novel;Oligodendroglia;Pathway interactions;Penetration;Peptides;Pericytes;Population;Probability;promoter;Protein Tyrosine Phosphatase;PTEN gene;receptor;receptor function;Recovery;Recovery of Function;regenerative;regenerative approach;regenerative therapy;repaired;Research Personnel;Rodent;Signal Transduction;SOX11 gene;Spinal cord injury;Synapsins;Technology;technology validation;tool;transduction efficiency;Transduction Gene;transgene expression;Transgenic Mice;Translating;Tropism;Up-Regulation;vector;Viral Vector;Virus;Wild Type Mouse

PROJECT_TITLE: Bioengineering of highly effective AAV vectors for noninvasive gene delivery to the nervous system

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]