NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Carriers of the APOE4 gene are at a significantly increased risk of developing Alzheimer’s disease (AD), and recent epidemiological studies have shown that APOE4 carriers who are infected with the herpes simplex virus 1 (HSV-1) have an even higher risk of AD. In order to investigate the potential synergy between APOE4 and HSV-1 in AD susceptibility, we will perform a series of experiments where APOE mice and cells are infected with HSV-1 for long periods of time, and the effects on memory and pathology are assessed. We will also test the effects of an antiviral medication to prevent these effects.

PI_NAMEs: CLIFFE, ANNA RUTH;NURIEL, TAL  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: acute infection;Address;Adult;Age;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Apolipoprotein E;apolipoprotein E-4;Automobile Driving;Bioinformatics;Biology;Brain;brain cell;Brain region;brain tissue;cell type;Cells;Cognitive;Cognitive deficits;cognitive function;cognitive performance;Collaborations;Data;Dementia;Development;Disease Progression;Disease susceptibility;DNA Primase;efficacy evaluation;Elderly;epidemiology study;Exhibits;experience;experimental study;follow-up;Future;gene network;Genes;Genotype;Gliosis;Goals;Health Care Costs;helicase;Herpes Simplex Infections;Herpesvirus 1;high risk;Hippocampus;human old age (65+);Immunology;Impaired cognition;In Vitro;in vitro Model;in vivo;Individual;Infection;Inflammatory;inhibitor;interest;Iron;late life;Late Onset Alzheimer Disease;latent infection;Literature;Long-Term Effects;Memory;Memory impairment;Modeling;Mus;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;novel therapeutic intervention;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Permeability;Persons;Physiological;Population;Positioning Attribute;prevent;Primary Infection;Protein Isoforms;Protocols documentation;Research;Resolution;Risk;Risk Factors;Role;Series;Simplexvirus;spatial memory;synergism;tau Proteins;Testing;Time;transcriptome sequencing;transcriptomics;translational study;Treatment Protocols;Viral

PROJECT_TITLE: Investigating the role of long-term latent herpes simplex virus infection on APOE4-associated Alzheimer's disease pathogenesis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Sleep Research

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative  The overall goal of this proposal is to obtain a better mechanistic understanding of resilience to aging at the molecular, cellular, organ, and systemic physiological levels in order to identify therapeutic targets. The public health significance relates to the ability to therapeutically enhance resilience to aging and age-related diseases in individuals predicted to be less resilient.

PI_NAMEs: LADIGES, WARREN C (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acute;Age;age related;age-related disease;Aging;aging related;Area;biological adaptation to stress;Biological Assay;Biometry;Biopsy;Body fat;Categories;Cells;Characteristics;chemotherapeutic agent;Classification;Clinical Research;Cutaneous;Cyclophosphamide;Data;design;Diabetes Mellitus;digital imaging;Ear;Evaluation;Funding;gene product;Geropathology;Goals;Grant;healing;Health;healthy aging;Heart Diseases;human old age (65+);Immunohistochemistry;Impaired cognition;Individual;individual variation;Insulin Resistance;Intervention;Investigation;Learning;Lesion;Life;luminescence;Lymphocyte;Malignant Neoplasms;Measures;Memory;Memory Loss;middle age;Molecular;Molecular Analysis;molecular imaging;Mus;Muscle;muscle form;nanoscale;neutrophil;old mice;Older Population;Organ;Parents;Pathologic;Pathway Analysis;Pathway interactions;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Physically Challenged;Physiological;pre-clinical;Predisposition;promote resilience;protective factors;Proteins;Public Health;Punch Biopsy;resilience;resilience in aging;Resistance;response;Rheumatoid Arthritis;Risk Factors;Sleep disturbances;Stress;Stressful Event;stressor;System;Therapeutic;therapeutic target;Thinness;tissue repair;Tissues;trait;transcriptome sequencing;transcriptomics;Trauma;wound;Wound models

PROJECT_TITLE: Physical resilience is a predictor of healthy aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Very little is known about immunological memory to COVID vaccines. The proposed study investigates how useful T cell memory is formed and maintained. These data will provide critically needed information on human T cell response to the new mRNA vaccines and uncover novel insights that may enable better immunization strategies in the future.

PI_NAMEs: SU, LAURA  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;Address;Antigens;Apoptosis;Attenuated;Benchmarking;Biological;CD4 Positive T Lymphocytes;Cells;Coronavirus Infections;COVID-19;COVID-19 vaccine;cross reactivity;cytokine;Data;Development;Disease Outbreaks;Dose;emerging pathogen;Event;experience;experimental study;Fine needle aspiration biopsy;fitness;flexibility;Future;Human;Immune;Immunity;Immunologic Memory;improved;Individual;Infrastructure;insight;Knowledge;Link;Longevity;lymph nodes;Maps;Memory;Modeling;Molecular;Mus;Mutate;Mutation;novel;novel coronavirus;Parents;pathogen;Peptide/MHC Complex;Peripheral;Population;preservation;Production;Property;protein aminoacid sequence;Proteins;recruit;Research;Resources;response;RNA vaccine;Shapes;social;T cell receptor repertoire sequencing;T cell response;T memory cell;T-cell diversity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;tool;ultrasound;Up-Regulation;Vaccination;vaccination strategy;vaccine platform;vaccine response;vaccine strategy;Vaccines;Variant;Viral;Virus;Work;Yellow Fever Vaccine;Yellow fever virus

PROJECT_TITLE: The impact of T cell selection on vaccine durability

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE In order to colonize and inhabit the human microbiome, both pathogenic and commensal microbes must adapt to withstand complex stressful conditions, such as oxygen and nutrient limitation. Investigation into how the interaction of stresses influence microbial evolution is important for a deeper understanding of the infectious disease process and can lead to future targets for antimicrobial therapies and novel approaches to disease prevention.

PI_NAMEs: BEHRINGER, MEGAN GRACE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project narrative Mitis group streptococci are recognized as causative agents of a variety of human diseases and have shown to be resistant to numerous antibiotics. This study aims to identify how cellular stress and immune responses contribute to bacterial recognition and clearance during infection. In addition, the study could potentially identify new target strategies to combat the action of these pathogens.

PI_NAMEs: VAN DER HOEVEN, RANSOME  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute suppurative arthritis due to bacteria;Address;Alveolar;Antibiotics;ATF2 gene;Bacteremia;Bacteria;Biochemical;biological adaptation to stress;Biological Models;Blood;Caenorhabditis elegans;Cancer Patient;Cardiac Myocytes;Cell Death;Cell Line;Cell Physiology;Cells;Cellular Stress;Cellulitis;Cessation of life;chemotherapy;Clinical;clinically significant;combat;community acquired pneumonia;cytotoxicity;Dedications;Development;Disease;Endocarditis;Epithelial Cells;Fibroblasts;Functional disorder;Genetic;Gingiva;Homeostasis;Human;human disease;Hydrogen Peroxide;Immune;immune activation;Immune response;Immunocompromised Host;Infection;Infective endocarditis;Ingestion;Innate Immune Response;Intestines;Invaded;Laboratories;Link;Lung;Macrophage;Mammals;Mediating;member;Metabolic;Metabolism;microorganism;model organism;Mus;Nematoda;novel;novel therapeutic intervention;opportunistic pathogen;oral bacteria;Oral cavity;Organism;Oropharyngeal;Oxidative Stress;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Post-Transcriptional Regulation;Predisposition;Production;Proteins;Regulation;Research Personnel;Resistance;response;Role;Sepsis;Signal Pathway;Stream;Streptococcus;Streptococcus mitis;Streptococcus oralis;Streptococcus pneumoniae;Stress Response Signaling;Testing;Therapeutic;Time;Tissues;transcription factor;Virulence Factors;Whole Organism;Work

PROJECT_TITLE: Pathogen-induced immune and stress responses mediated by bZIP transcription factors

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner violence, and police and other violence) and HIV-associated noncommunicable diseases (HIVNCD) in a population of sexual and gender minorities living with HIV/AIDS in Nigeria. It will provide critical data for informing the development of integrated, multilevel interventions intended to remediate disparities in HIVNCD and their outcomes among sexual and gender minorities in sub-Saharan Africa and other similar settings.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);DYER, TYPHANYE VIELKA;ROBINSON, RACHEL SULLIVAN

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Africa South of the Sahara;Blood;cardiometabolic risk;Caring;Chronic Obstructive Pulmonary Disease;cohort;Communities;Continuity of Patient Care;Data;Data Analyses;Development;deviant;Diabetes Mellitus;Discrimination;Disease;Disease Clusterings;Disease Outcome;Disparity;Dyslipidemias;Economics;experience;Exposure to;follow-up;gender minority group;Health behavior;health care availability;Heart;HIV;HIV risk;HIV/AIDS;Hypertension;indexing;Inequality;Inequity;Interdisciplinary Study;Intervention;Interview;intimate partner violence;Knowledge;Lead;life history;low and middle-income countries;Lung;Maryland;Measures;men who have sex with men;Mental Depression;Military Personnel;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Nigeria;Obesity;Outcome;Participant;perceived discrimination;Police;Policies;polysubstance use;poor health outcome;Population;Prevalence;programs;Public Health;remediation;Research;Research Personnel;Risk;Risk Factors;Sexual and Gender Minorities;sexual minority group;social;social capital;social norm;Social status;social stigma;Social support;Stigmatization;Stress;syndemic;Testing;Time;Universities;Victimization;Violence;Woman;Work

PROJECT_TITLE: Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: We lack sufficient data about the complex relationships between cancer and aging, leaving survivors and their oncology teams with insufficient evidence to guide chronic disease and cancer care. My cancer and aging laboratory will lead teams of basic, clinical and population science researchers to fill this gap by providing a mechanistic understanding of the role of aging processes in population health outcomes. We will use this paradigm to conduct human and animal studies to Identify and test aging mechanistically-based interventions that can support efforts to tailor clinical care for the growing cancer survivor population.

PI_NAMEs: MANDELBLATT, JEANNE  (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Acceleration;Advocate;age acceleration;Aging;aging process;Animals;Area;Automobile Driving;Award;Black race;cancer care;cancer health disparity;Cancer Survivor;Cancer Survivorship;career;Caring;Cell Aging;clinical care;clinically relevant;cohort;Cohort Studies;Collaborations;Complex;Data;demographics;Discipline;Disease;Disparity;drivers of aging;Environment;Epigenetic Process;ethnic minority;Ethnic Origin;Exposure to;Funding;Gene Expression;Geroscience;Goals;health determinants;health disparity;health inequalities;Hispanic;Human;human old age (65+);Inflammatory;Infrastructure;insight;Institution;intersectionality;Intervention;Knowledge;Laboratories;Lead;Machine Learning;Malignant Neoplasms;Mediation;Methods;Minority;Modeling;Mutation;novel;Oncology;Outcome;Pathway interactions;Policies;Population;Population Sciences;pre-clinical;Pre-Clinical Model;programs;Public Health;Quality of life;Race;racial minority;Research;Research Personnel;Risk;Role;Scientist;Signal Transduction;simulation;social health determinants;Stress;success;Survivors;survivorship;Testing;transcriptomics;Transducers;Translating;United States National Institutes of Health;virtual;Vision

PROJECT_TITLE: Investigations CONNECTing Cancer and Aging (I-CONNECT)


NIH_SPENDING_CATS: Aging;Genetics;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Aging causes a loss of skeletal muscle mass and function (sarcopenia). The goal of this project is to explore how the hundreds nuclei within skeletal myofibers maintain muscle size and function, and mechanisms by which this becomes dysregulated during aging.

PI_NAMEs: MILLAY, DOUGLAS PAUL (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Accounting;Adult;age acceleration;aged;Aging;Atrophic;Biological Phenomena;Breathing;Cell fusion;Cell Nucleus;Cell Size;Cells;Chronic;combat;Compensation;Cytoplasm;Data;Development;Elderly;Exhibits;functional loss;Gene Dosage;Gene Expression Profile;Genetic;Genetic Transcription;Giant Cells;Goals;Growth;Health;healthspan;Homeostasis;insight;Knowledge;life span;Link;Maintenance;Metabolism;Modeling;Molecular;Morphology;mouse model;Movement;multiple omics;Mus;Muscle;muscle aging;muscle form;Muscle function;muscle progenitor cell;Muscle satellite cell;Muscular Atrophy;novel;novel therapeutic intervention;Nuclear;Output;Physiological;Population;precursor cell;premature;preservation;Prevalence;Process;Regulation;resilience;Role;sarcopenia;senescence;single nucleus RNA-sequencing;skeletal;Skeletal Muscle;skeletal muscle wasting;System;Technology;Testing;Titrations;tool;Transcriptional Activation;Transcriptional Regulation

PROJECT_TITLE: Myonuclear dynamics during skeletal muscle aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The risk of assigning an inaccurate diagnosis of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) is high among older Chinese Americans due to language barriers and cultural differences. Although the English and Spanish versions of the National Alzheimer’s Coordinating Center’s Uniform Data Set assessment battery have been successfully created and utilized for AD/ADRD research, the battery is not available in Chinese languages, despite being the third most spoken languages in the US. The availability of appropriate cultural/linguistic test batteries and corresponding normative data will yield more accurate interpretation and diagnosis of AD/ADRD for older Chinese Americans, which can lead to improved health equity and reduced disease/treatment disparities in this underrepresented group.

PI_NAMEs: LI, CLARA  (contact);TEE, BOON LEAD

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Adult;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Assessment tool;bilingualism;brain magnetic resonance imaging;California;Chinese;Chinese American;Clinical assessments;Cognition;Cognitive;Cognitive deficits;cognitive performance;cohort;Communities;community advisory board;cost;Data;Data Set;Databases;Dementia;Detection;Development;Diagnosis;diagnostic accuracy;Disease;Educational Status;Enrollment;equity, diversity, and inclusion;ethnic minority;Evaluation;Funding;Future;Geography;Goals;Health;health equity;high risk;improved;Individual;Instruction;Language;Linguistics;Magnetic Resonance Imaging;medical schools;Minority Health Research;multidisciplinary;neural correlate;Neuroanatomy;neuroimaging;neuromechanism;Neuropsychology;Not Hispanic or Latino;novel;older adult;outreach program;Participant;Population;prognostication;programs;Psychometrics;Publishing;racial minority;Records;recruit;Reporting;Research;Risk;Sampling;San Francisco;Scientist;Site;sociodemographics;Spanish/English;Standardization;Testing;Translations;treatment disparity;Underrepresented Populations;Underserved Population;Universities;Update;Work;Writing

PROJECT_TITLE: Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation study

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The Yale-murine Tissue Mapping Center project aims to use high-throughput, high-resolution single-cell and spatial omics technologies to characterize senescent cell heterogeneity with special emphasis on the immune cells in various tissues. This data resource will advance the understanding of senescent cells, their biomarkers and mechanism of aging.

PI_NAMEs: DIXIT, VISHWA DEEP (contact);MONTGOMERY, RUTH R

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;aged;Aging;aging mechanism;Agreement;analysis pipeline;Anti-Inflammatory Agents;Antibodies;B-Lymphocytes;Biological;Biological Markers;Biology;biomarker identification;Biomedical Engineering;Bone Marrow;CCL2 gene;CCL3 gene;Cell Aging;Cell Cycle Arrest;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Chronic;Classification;Communities;Complement 3d;Complex;cytokine;Data;Data Analytics;data resource;Dedications;Dimensions;Environment;experience;exposed human population;Fibroblasts;Fostering;functional decline;Generations;genome-wide;Geroscience;Growth Factor;Hematopoietic;Heterogeneity;HMGB1 gene;Homeostasis;Human;Human Resources;IL8 gene;Image;Immune;Immune system;Immunologics;Immunologist;Immunophenotyping;Inflammation;Inflammatory;Informatics;Interleukin-1 beta;Interleukin-6;Iron;Label;Leukocytes;Light;Lipolysis;Lymphoid Tissue;Macrophage;Maps;Measures;Mesentery;Messenger RNA;Metabolism;Microscopy;Molecular;mouse model;multidisciplinary;multiple omics;multiplexed imaging;Mus;Natural Killer Cells;Normal tissue morphology;Organ;pathogen;pathogen exposure;Pathologist;Peripheral Blood Mononuclear Cell;Phenotype;programs;Proliferating;Property;Proteins;PTPRC gene;Reporter;Research;Resolution;response;senescence;senescence associated secretory phenotype;senescent cell;single cell analysis;single cell proteins;Sorting;Specimen;Spleen;synergism;T memory cell;Technology;Testing;Thymic epithelial cell;Thymus Gland;tissue injury;tissue mapping;Tissues;TNF gene;transcriptomics;Translating

PROJECT_TITLE: Yale Murine-TMC on Immune Cell Senescence Derived Inflammation


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: MONTGOMERY, RUTH R (contact)

PROJECT_TERMS: Address;Advanced Development;Advisory Committees;Aging;Atlases;Biological;Biology of Aging;Cell Aging;Collection;Communication;Communities;Consult;Consultations;Controlled Environment;cost effective;Data;Data Analyses;Data Analytics;Data Coordinating Center;data sharing;Data Storage and Retrieval;data visualization;Decision Making;Development;Ensure;experience;Funding;Future;Generations;genetic manipulation;Geroscience;Goals;Human;Immune;Immunologics;immunosenescence;Inflammaging;Inflammation;innovation;Institution;Intellectual Property;Intramural Research Program;Investigation;Kinetics;Laboratory mice;life span;Lymphoid;Maps;meetings;Metabolic;Monitor;mouse model;Mouse Strains;Mus;new technology;novel;Organ;Participant;Pilot Projects;Procedures;Progress Reports;Publications;Quality Control;Reagent;Research;Research Personnel;Research Project Grants;Research Training;Resolution;Resources;Role;senescent cell;Site;specific biomarkers;Specimen;Standardization;success;synergism;Technology;tissue mapping;Tissues;tool;Transgenic Mice;United States National Institutes of Health;Visualization software

PROJECT_TITLE: Core A: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-M]


PI_NAMEs: FAN, RONG  (contact)

PROJECT_TERMS: 3-Dimensional;Adipose tissue;aged;Aging;Agreement;Animal Model;Area;Atlases;Biological;Biological Assay;Biological Markers;Biology of Aging;Biomedical Engineering;Bone Marrow;Breathing;Categories;Cell Aging;Cell Lineage;cell type;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Collaborations;Computational Biology;Cytometry;Devices;Disease;Environment;Evaluation;exposed human population;Fluorescence;genome-wide;Goals;Hematopoietic;Heterogeneity;Human;Image;Immune;Immune system;Immunobiology;immunosenescence;In Situ;in vivo;Inflammation;Inflammatory;interest;Investigation;Iron;Label;Light;Lymphoid;Macrophage;Maps;Measures;Mesentery;Messenger RNA;Microscopy;Modality;Modeling;Molecular;molecular imaging;Motivation;mouse model;multiple omics;multiplexed imaging;Mus;nano-string;novel;novel marker;Organ;pathogen exposure;Peripheral Blood Mononuclear Cell;Process;Production;Proteins;PTPRC gene;Reporter;Reproducibility;Research;Resolution;RNA analysis;Sampling;Scanning;senescence;senescence associated secretory phenotype;senescent cell;single cell analysis;Slide;Sorting;spatial integration;Specimen;Speed;Spleen;Standardization;Stromal Cells;synergism;System;Techniques;Technology;Thymic epithelial cell;Thymus Gland;Tissue atlas;tissue mapping;Tissues;tool;Training;transcriptome

PROJECT_TITLE: Core B - Biological Analysis


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Mental Health;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed study will establish the feasibility and acceptability of a dyadic mind-body intervention, “Recovering Together after Cardiac Arrest (RT-CA).” RT-CA aims to improve emotional distress and quality life in cardiac arrest survivors and their informal caregivers (i.e., family or friends who provide the majority of support), which is an under- resourced population that experiences chronic distress (40-61%). RT-CA has the potential to improve cardiac arrest survivorship for survivors and their caregivers by teaching mind-body skills and providing necessary resources to navigate survivorship challenges.

PI_NAMEs: PRESCIUTTI, ALEXANDER MATTIA (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;American;Anoxia;arm;Artificial Heart;Brain;Brain Injuries;career;Caregivers;Caring;Cessation of life;Characteristics;Chronic;Circulation;Clinical;Clinical Psychology;Clinical Trials;Cognitive;Cognitive Therapy;Coma;Complementary Health;Complex;coping;Critical Care;Critical Illness;Data;deprivation;Development;Dialectical behavior therapy;Distress;diversity and equity;Educational process of instructing;Educational workshop;Emergency Medicine;emotional distress;emotional symptom;Enrollment;Environment;evidence base;experience;Family;feasibility testing;Feedback;Focus Groups;Friends;Funding;Future;General Hospitals;Goals;Health;health equity;Heart;Heart Arrest;Hospitals;improved;informal caregiver;Injury;Institution;Integrative Medicine;Intensive Care Units;Intervention;intervention refinement;Interview;Link;Massachusetts;Meaning and purpose;Medical;medical schools;Meditation;meetings;member;Mentors;Mentorship;Methodology;Methods;Mind;Mind-Body Intervention;mind/body;mindfulness;mindfulness-based stress reduction;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;National Center for Advancing Translational Sciences;National Center for Complementary and Integrative Health;Neurobehavioral Manifestations;neurological recovery;Numbness;Outcome;Outcomes Research;Oxygen;Participant;Patients;physical symptom;Physicians;Physiologic pulse;Population;pre-doctoral;prevent;Process;programs;psychoeducation;Psychologist;Psychotherapy;Qualitative Methods;Quality of life;randomized, clinical trials;Recommendation;recruit;Recurrence;Relaxation;Research;Research Personnel;Research Priority;resilience;Resources;response;Resuscitation;Risk;satisfaction;Services;Site;skills;Social support;standard of care;Strategic Planning;Stroke;Structure;success;Support Groups;Survivors;survivorship;Testing;therapy development;TNFSF15 gene;Training;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: Recovering Together after Cardiac Arrest: A dyadic mind-body intervention for emotional distress in cardiac arrest survivors and their informal caregivers


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE The tobacco use burden in Lebanon is exceptionally high: 35% of adults are current cigarette smokers and 39% are current waterpipe smokers. The evidence for smoking cessation interventions comes primarily from high-income countries and they have rarely been tested in low-resource settings. The objective of this proposal is to evaluate the comparative effectiveness of promising multi-component interventions for implementing evidence-based cessation treatment in Lebanon’s national system of primary healthcare centers.

PI_NAMEs: NAKKASH, RIMA ;SALLOUM, RAMZI GEORGE (contact)

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Abstinence;Address;Administrator;Adoption;Adult;American;arm;Behavioral;brief advice;Cancer Control;cancer prevention;Carbon Monoxide;Cigarette Smoker;Clinic;comparative effectiveness;contextual factors;cost;cost effective;cost effectiveness;Counseling;Country;design;dissemination science;effectiveness testing;evidence base;Exploration, Preparation, Implementation, and Sustainment;Female;Focus Groups;follow-up;Fostering;Goals;Health Personnel;Health system;health training;hookah;Hybrids;implementation determinants;implementation evaluation;implementation process;implementation science;implementation/effectiveness;Incidence;Income;Infrastructure;Institution;interest;Intervention;Interview;Lebanon;low and middle-income countries;male;Malignant neoplasm of lung;Measures;Medical center;Mediterranean Region;Methods;Modeling;Morbidity - disease rate;mortality;multi-component intervention;nicotine replacement;Patient Self-Report;Patients;Persons;Pharmacotherapy;Population;Prevalence;Primary Care;primary care patient;primary care setting;Primary Health Care;primary health center;programs;Protocols documentation;Provider;Public Health;public health relevance;randomized trial;Recommendation;reduce tobacco use;Research;Resource-limited setting;Resources;safety net;Services;Smoke;Smoker;smoking cessation;Smoking Cessation Intervention;standard care;success;Surveys;System;Telephone;Testing;Tobacco;Tobacco Dependence;Tobacco use;treatment program;trial comparing;Universities;World Health Organization

PROJECT_TITLE: Phone Enabled Implementation of Cessation Support (PHOENICS)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KLUGER, YUVAL  (contact)

PROJECT_TERMS: Algorithms;Atlases;Basic Science;Bioinformatics;Biological;Biological Markers;biomarker identification;biomarker signature;biomarker validation;Catalogs;Cell Aging;cell type;Cells;Clinical Research;Communities;Computer Analysis;computer infrastructure;computerized data processing;Core Facility;Data;Data Analyses;data analysis pipeline;Data Coordinating Center;data integration;data management;data modeling;data resource;Data Set;data sharing;data standards;Data Storage and Retrieval;data visualization;Databases;Deposition;design;Development;Environment;Fatty acid glycerol esters;feature selection;Generations;Genomics;Geroscience;Goals;graphical user interface;high dimensionality;Histology;Image;Immune;Inflammation;Informatics;informatics infrastructure;interoperability;Ligands;Link;Lymphoid Tissue;Maps;Measures;member;Metadata;Methodology;Methods;Mission;Modality;Molecular;mouse model;multidimensional data;multimodal data;multiple omics;Mus;next generation;Online Systems;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;Process;Proteomics;Protocols documentation;quality assurance;receptor;Sampling;senescence;senescent cell;software development;Spleen;Statistical Data Interpretation;Stromal Cells;System;Thymus Gland;Tissue Sample;Tissue Stains;Tissues;tool;transcriptome sequencing;transcriptomics;Translational Research;United States National Institutes of Health;Validation;Visualization software;web portal;Work

PROJECT_TITLE: Core C


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Children living in rural regions of the United States (US) have reduced access to medical care and few chances to participate in research. This project will address this problem by working in collaboration with a group of pediatric researchers to develop and conduct research studies that improve general knowledge of diseases common in children in rural areas, such as asthma, opioid addiction, and obesity. By enhancing the research skills of junior researchers and supporting research interactions with communities, this project will increase research participation and enhance the health of children living in rural regions of the US.

PI_NAMEs: PERRY, TAMARA TAYLOR (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: 18 year old;Abbreviations;Academy;Acceleration;Affect;Airway Disease;Area;Arkansas;Asthma;Award;Biomedical Research;Caring;Centers of Research Excellence;Child;Child Development;Child Health;Child health care;child services;Childhood;Clinical;Clinical and Translational Science Awards;clinical care;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;college;Communities;community advisory board;community engagement;Community Health Aides;community partnership;Competence;Data;Development;Diabetes Mellitus;Digestive System Disorders;Disease;Economics;Education;Enrollment;Ensure;Environmental Science;experience;Faculty;Funding;Future;Generations;gestational weight gain;Grant;Health;health disparity;Healthcare Systems;improved;innovation;Institution;Institutional Review Boards;Kidney Diseases;Knowledge;Leadership;Link;Medical;Mentors;Mission;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal Abstinence Syndrome;neurodevelopment;Obesity;obesity-associated asthma;operation;Opiate Addiction;Out-Migrations;Outcome;outreach;Patient-Focused Outcomes;pediatric department;Pediatric Hospitals;pediatric pharmacology;Perinatal;Population;postnatal;prenatal;programs;Public Health;Puerto Rico;Research;Research Institute;Research Personnel;research study;Research Support;Resource-limited setting;Resources;Rural;rural area;Rural Community;Science;Scientist;Site;skills;success;telehealth;Telemedicine;tertiary care;Testing;tool;Translational Research;treatment arm;treatment as usual;United States;United States National Institutes of Health;Universities;Veterans;Vitamin D supplementation;Vulnerable Populations;Work

PROJECT_TITLE: Arkansas ECHO ISPCTN Site (AREIS)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE African-American women have disturbingly high rates of CHD relative to women of other racial/ethnic backgrounds, and sleep disturbance is hypothesized to be an important driver of this excess risk. Yet the determinants of sleep disturbance in African-American women remain poorly understood. The goal of the proposed research is to determine whether and how “shifting,” a commonly described, but understudied phenomenon with high relevance for African-American women, might be associated with sleep disturbance and elevated CHD risk in this group.

PI_NAMEs: LEWIS, TENÉ T (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: actigraphy;Affect;African American;African American Women;aged;Attention;Behavior;Biological Markers;Blood Glucose;Blood Pressure;Body mass index;cardiometabolic risk;Cessation of life;Chronic;Coronary heart disease;Data;Depressed mood;design;Development;diaries;disability;Discrimination;Emotional;Ethnic Origin;Ethnic Population;experience;Financial Hardship;follow-up;Goals;Health;heart disease risk;improvement on sleep;Intervention;Knowledge;Measures;Mediating;men;middle age;Midlife women;negative affect;novel;Pattern;poor sleep;Population;Poverty;Process;programs;prospective;psychologic;psychosocial;Psychosocial Stress;Questionnaires;Race;racial population;Religion;Reporting;Research;resilience factor;Risk;Risk Reduction;Self Care;self-compassion;Services;Sleep;Sleep disturbances;sleep quality;social culture;Social Interaction;Societies;Socioeconomic Status;Speech;Stress;stressor;vigilance;Vulnerable Populations;Woman;Women Status;Women's Group

PROJECT_TITLE: Sociocultural Shifting, Sleep and Cardiometabolic Risk in African-American Women

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Nanotechnology;Orphan Drug;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Multiple myeloma is a cancer of bone marrow plasma cells that remains virtually incurable, partly to interactions with the bone marrow microenvironment, which promote colonization, progression, and survival of myeloma cells. During the F99 phase, I will develop biomaterials-based strategies to deliver nucleic acids to the bone marrow microenvironment, as a novel form of multiple myeloma therapy, to disrupt interactions between myeloma cells and the bone marrow. For the K00 phase, I propose to study cell-cell interactions in the tumor immune microenvironment that promote myeloma progression and drug resistance employing high-dimensional single-cell approaches and tissue-engineered models, to ultimately uncover novel therapeutic targets.

PI_NAMEs: FIGUEROA-ESPADA, CHRISTIAN GABRIEL (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: adhesion receptor;Adhesions;Antineoplastic Agents;Antitumor Response;aptamer;Architecture;ATAC-seq;Big Data;Binding;Biocompatible Materials;Bioinformatics;Biomedical Engineering;Blood Circulation;Bone Marrow;Bortezomib;Cancer Biology;cancer drug resistance;cancer therapy;Cell Adhesion;Cell Communication;Cells;Cessation of life;Chemistry;Clinic;Clinical;clinical translation;Complex;Custom;Cyclophilin A;design;Development;Disease;dosage;Drug Delivery Systems;Drug resistance;E-Selectin;effective therapy;Encapsulated;Endothelial Cells;Endothelium;Engineering;Formulation;Funding;Gene Silencing;Genetic Transcription;Goals;Hematologic Neoplasms;high dimensionality;Histology;Homing;Hybrids;improved;In Vitro;in vitro Assay;in vivo;innovation;Knowledge;Laboratories;Laboratory Research;Libraries;Ligands;Lipids;Malignant Bone Marrow Neoplasm;Malignant Neoplasms;Mechanics;Membrane;Mentors;Messenger RNA;Methods;Microfluidics;migration;Migration Assay;Modality;Modeling;Multiple Myeloma;Mus;nanoparticle;Nanotechnology;Neoplasm Metastasis;new therapeutic target;novel;nucleic acid delivery;Nucleic Acids;Patients;Pennsylvania;Phase;Plasma Cells;Polyethylene Glycols;Polymers;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Property;Proteasome Inhibitor;Research;Research Project Grants;Resistance;Resistance development;RNA Interference Therapy;RNA Sequences;screening;siRNA delivery;skills;Small Interfering RNA;small molecule;Specificity;Surface;targeted delivery;Technology;Testing;Therapeutic;therapeutic nanoparticles;therapeutic RNA;therapeutic siRNA;therapeutic target;three-dimensional modeling;Tissue Engineering;Training;transcriptome sequencing;Translating;tumor;Tumor Biology;Tumor Burden;tumor microenvironment;tumor progression;tumor-immune system interactions;United States;United States National Institutes of Health;Universities;virtual;whole body imaging;Work;Xenograft Model

PROJECT_TITLE: Engineering Biomaterials to Modulate the Bone Marrow Microenvironment in Multiple Myeloma


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative  Stroke is a leading cause of death and disability, and accounts for more than 5.5 million deaths each year worldwide. The ability to noninvasively image brain oxygenation in these patients is a critical unmet need that will help stratify patients for emerging therapies. This project develops novel MRI methods to quantify brain tissue oxygenation, and enhances these measurements with simultaneous [15O]-oxygen PET on a hybrid PET/MRI scanner. PET/MRI also is optimally leveraged to assess oxygen metabolism dynamics that support functional brain connections at rest. Our study will provide innovative, accessible imaging tools to understand altered cerebral oxygen metabolism in cerebrovascular patients and how it relates to brain network dysfunction.

PI_NAMEs: FAN, AUDREY PEIWEN (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Algorithms;Area;arterial spin labeling;Biological Markers;biophysical model;Blood capillaries;blood oxygen level dependent;Blood Vessels;Brain;Brain imaging;brain magnetic resonance imaging;Brain scan;brain tissue;Calibration;Cause of Death;cerebral oxygenation;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Cessation of life;Clinical;clinical application;Communities;Complex;Consumption;Data;deoxyhemoglobin;Development;Dictionary;disability;Disease;Fingerprint;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Gases;gray matter;hemodynamics;Human;human imaging;Hybrids;Image;imaging approach;imaging biomarker;Imaging Device;Impairment;improved;in vivo;innovation;Intracranial Arterial Stenosis;Joints;kinetic model;Kinetics;Knowledge;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Metabolic;metabolic rate;Metabolism;Methods;Modality;Modeling;Molecular;Monitor;MRI Scans;network dysfunction;neuroimaging;Neurologic;neuroprotection;Neurosciences;non-invasive imaging;novel;novel imaging technique;Outcome;Output;Oxygen;Oxygen Consumption;Participant;Pathologic;Pathology;patient stratification;Patients;Pattern;Perfusion;Phase;Physiological;Physiology;Positron-Emission Tomography;Predisposition;radiotracer;reconstruction;Reference Standards;Resolution;Rest;revascularization;Sampling;Scanning;Signal Transduction;simulation;Site;Specificity;Stenosis;Stroke;stroke risk;success;System;Time;tissue oxygenation;Tissues;tool;Tracer;Translations;Validation;Veins;Water;Work

PROJECT_TITLE: Imaging of human brain oxygenation and oxygen metabolism dynamics


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The COVID-19 pandemic is caused by the Sars-CoV-2 coronavirus that has infected over 40 million people worldwide, has resulted in >210,000 deaths in the U.S., and is expected to cost the U.S. health care system $8 trillion. The primary goal of the proposed research is to define the mechanisms by which dysregulation of the blood clotting system mediates severe COVID-19 disease. This research program is highly relevant to public health because it will foster creative discoveries for targeting clotting factors to develop improved therapies for treating Sars-CoV-2-infected patients to reduce COVID-19 morbidity and mortality.

PI_NAMEs: FLICK, MATTHEW J. (contact);GRALINSKI, LISA ;WOLBERG, ALISA S.

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;Alveolar;Automobile Driving;Autopsy;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Vessels;Body System;C-reactive protein;Capsid Proteins;Cell surface;Cessation of life;Clinical;Clinical Management;Coagulation Process;Coronavirus;coronavirus disease;Coronavirus Infections;coronavirus receptor;cost;Coupling;COVID-19;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;Creativeness;cytokine release syndrome;Data;Deposition;Disease;Disparity;Engineering;experience;Fibrin;Fibrin fragment D;Fibrinogen;Fibrosis;Fostering;Functional disorder;Goals;Healthcare Systems;Hematology;Hemorrhage;Hemostatic Agents;Human;human coronavirus;Hypoxia;Immune response;Immunologics;improved;Individual;Infection;Inflammatory;inflammatory marker;Inflammatory Response;insight;Integration Host Factors;Interleukin-6;Knowledge;Leukocytes;Link;Lung;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Mutation;novel;novel coronavirus;Organ;Organ failure;Outcome;Pathogenicity;Pathology;patient response;patient variability;Patient-Focused Outcomes;Patients;Persons;Plasminogen;programs;Public Health;Pulmonary Edema;Pulmonary Inflammation;reduce symptoms;Reporting;Research;severe COVID-19;Structure of parenchyma of lung;Surface;Symptoms;System;systemic inflammatory response;Testing;Thrombophilia;Thrombosis;Tissues;tool;translational potential;Translations;trigger point;Viral Proteins;Virus;Virus Replication

PROJECT_TITLE: Mechanisms linking the plasminogen/fibrinogen axis to the pathogenesis of COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The oligomerization of amyloid proteins/peptides majorly contributes to the development of some dementia diseases such as Alzheimer's disease, which is associated to the oligomerization of amyloid-β peptides and tau protein. Inhibiting the amyloid oligomerization and eliminating the toxic amyloid oligomers will prevent the disease development.

PI_NAMEs: MAN, VIET HOANG (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;abeta oligomer;Abeta synthesis;Academy;Acetylcholine;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid formation;Amyloid Proteins;Artificial Intelligence;Authorization documentation;base;Biological Assay;Brain;career;career development;Cells;Characteristics;Clinical Trials;Computers;Computing Methodologies;data access;Data Analyses;data resource;Dementia;design;Development;Development Plans;Disease;Dissociation;Doctor of Philosophy;Drug Compounding;Drug Screening;Education;Environment;Equipment;experimental study;Faculty;Fellowship;fighting;Focused Ultrasound;Focused Ultrasound Therapy;Frequencies;Goals;Grant;Huntington Disease;improved;In Vitro;inhibitor;injured;innovation;insight;Kinetics;Lasers;Leadership;Learning;Light;Machine Learning;man;member;Mentors;Methods;Molecular;molecular dynamics;molecular scale;monomer;Multicenter Studies;Natural Compound;Natural Products;Neurodegenerative Disorders;Neurons;novel;Outcome;Parkinson Disease;Pathologic;Pathologic Processes;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy Schools;Phototherapy;Physical therapy;Physics;Polishes;Postdoctoral Fellow;prevent;Prevention;Process;Program Development;protein aggregation;Protocols documentation;Radiation;rational design;Research;Research Activity;Research Personnel;Research Proposals;Resources;Schools;Science;Scientist;Side;Signal Transduction;simulation;skills;small molecule;Statistical Data Interpretation;Statistical Methods;Structure;Symptoms;System;targeted treatment;tau aggregation;tau Proteins;Testing;therapeutically effective;Training;Training Activity;treatment optimization;Ultrasonic wave;ultrasound;Universities;Validation;virtual;virtual screening

PROJECT_TITLE: Development of novel computational protocols to study amyloid oligomerization

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative This study is important to public health as it will be perhaps the first study to rigorously test a network-based intervention designed to increase cervical cancer (CC) screening and treatment in sub-Saharan Africa by empowering women who have been screened for CC to be critical change agents for CC screening among women in their social network. In settings of high HPV and CC prevalence such as Uganda, where virtually every family is touched by someone living with cervical cancer risk, successfully mobilizing screened women to be advocates for CC screening and treatment could have a significant impact in the fight to control CC. The study will also assess the ability of diverse clinics to integrate, implement and sustain the intervention over time.

PI_NAMEs: BOGART, LAURA M;WAGNER, GLENN JOHN (contact);WANYENZE, RHODA KITTI

PROJECT_TERMS: Acetic Acids;Adoption;advanced disease;Advanced Malignant Neoplasm;Advocacy;Advocate;Africa South of the Sahara;Cancer Advocacy;Cancer Control;Cancer Etiology;cancer prevention;cancer risk;Caring;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Client;Clinic;Clinical;Collaborations;comparison control;cost;cost-effectiveness evaluation;Country;Data;Development;Diffusion;Effectiveness;effectiveness/implementation trial;empowerment;Enrollment;Ensure;Equipment;Evaluation;evidence base;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Family;fighting;follow-up;Fright;Funding;Government;group intervention;Human Papillomavirus;Hybrids;implementation framework;implementation outcomes;implementation science;implementation strategy;Incidence;Income;indexing;innovation;Intervention;intervention effect;Interview;Knowledge;Lesion;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediator;medically necessary care;member;Methods;Motivation;multidisciplinary;Network-based;operation;Participant;Patients;peer;peer support;Periodicals;Phase;Positioning Attribute;premalignant;Preparation;Prevalence;prevent;Privatization;Provider;provider-level barriers;Public Health;Radiation therapy;Ramp;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;remediation;Reporting;Research Design;response;Rural;rural area;screening;Screening for cancer;screening services;Site;social influence;Social Network;social stigma;Structure;Supervision;Telephone;Testing;theories;therapy design;Time;Touch sensation;Training;treatment as usual;Uganda;uptake;urban area;virtual;Visual;Waiting Lists;Woman;Women's mortality

PROJECT_TITLE: A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention in Uganda


NIH_SPENDING_CATS: Aging;Assistive Technology;Atherosclerosis;Bioengineering;Cardiovascular;Diabetes;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Intervention of many cardiovascular diseases requires bypassing or replacing blood vessels. The current gold standard is the autograft, which causes donor site morbidity and often has limited supplies. The goal of this project is to test a redesigned biodegradable synthetic graft that can transform into an artery-like conduit in situ in preclinical animal models.

PI_NAMEs: TZENG, EDITH ;WANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acceleration;Address;Affect;age effect;aged;Aging;Animal Model;Architecture;Arteries;Arteriovenous fistula;artery occlusion;Atherosclerosis;Autologous;Autologous Transplantation;Automobile Driving;biodegradable scaffold;Biological;Bioreactors;Blood flow;Blood Vessels;Bypass;Caliber;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;cell motility;Cells;Clinical;clinical translation;comorbidity;controlled release;Coronary;cost;cytokine;Data;Deposition;design;Development;Devices;Diabetes Mellitus;diabetic;Diameter;effectiveness evaluation;Elasticity;elastomeric;Elastomers;Elderly;endothelial stem cell;Extracellular Matrix;Fiber;Goals;graft failure;graft function;Harvest;Human;Immune response;Impairment;Implant;improved;In Situ;infection risk;Infiltration;Inflammation;insight;Interleukin-10;Intervention;Kidney Failure;Knee;Knowledge;Limb structure;Modeling;Morbidity - disease rate;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Operative Surgical Procedures;Pathology;patient population;Patients;Performance;pre-clinical;Process;Property;Proteins;Rattus;reconstruction;Research;Rodent;Route;scaffold;Sheep;Site;Source;Speed;Sprague-Dawley Rats;stem cell population;Stromal Cells;Systemic disease;Technology;Testing;Tissues;Vascular Graft;Vein graft;wound healing

PROJECT_TITLE: Elastic, Degradable Vascular Grafts with Helical Microfibers

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Blood disorders that exhibit overproduction of blood components develop upon the acquisition of genetic mutations in genes such as CALR and result in disease states called myeloproliferative neoplasms (MPN). A major gap in our understanding of treating patients with MPN is the patient-to-patient variable outcome, including therapy-resistance to treatments such as interferon-alfa. Here, by applying novel tools that can sequence many genes in individual cells (`single-cell sequencing') on patient samples and mouse models, we seek to uncover the mechanisms of therapy-resistance.

PI_NAMEs: MULLALLY, ANN ;NAM, SEUNG HA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Binding;Biological Assay;Blood;Bone Marrow Aspiration;CD34 gene;CEBPA gene;Cell Nucleus;cell type;Cells;Chemicals;Chromatin;Clinical;Clonal Hematopoietic Stem Cell;cohort;Coupled;Data;Development;Disease;Disease remission;DNA Sequence Alteration;DNMT3a;effective therapy;Equilibrium;Exhibits;fitness;Genes;Genotype;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell expansion;Hematopoietic stem cells;Human;Immunophenotyping;in vivo;Individual;Induced Mutation;innovation;insight;Interferon alpha;JAK2 gene;Link;Lymphoid;Measures;Mediating;Megakaryocytes;Methods;Modeling;Molecular;monocyte;morphogens;mouse model;multiple omics;mutant;Mutate;Mutation;mutational status;Myelogenous;Myeloproliferative disease;neoplastic;novel;novel therapeutic intervention;Outcome;Pathology;Pathway interactions;patient subsets;patient variability;Patients;Production;progenitor;programs;Proteins;Recombinant Interferon Alfa;Resistance;response;Role;Sampling;Shapes;single cell sequencing;single nucleus RNA-sequencing;stem;stem cells;therapy resistant;tool;transcription factor;transcriptome;transcriptome sequencing;Tumor Burden;Up-Regulation

PROJECT_TITLE: Elucidating Mechanisms of Therapy-Resistance to Interferon-alfa in Myeloproliferative Neoplasm Stem Cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Dilated cardiomyopathy (DCM), a complex cardiac disease is a leading cause of heart failure. The emergence of induced pluripotent stem cell (iPSC) technology offers an experimental human-based model to predict and model individual disease manifestations. The goal of this project is to study the underlying mechanisms of DCM by investigating the intricate crosstalk between cardiomyocytes and endothelial cells using bioengineering tools and next generation sequencing. Results from this work could potentially lead to new strategies that could lower morbidity and mortality, but also improve the management of DCM patients.

PI_NAMEs: SAYED, NAZISH  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;ATAC-seq;Attention;Biomedical Engineering;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cardiovascular Physiology;Cell Communication;Cell Line;cell type;Cells;Chromatin;Chromosome Mapping;Coculture Techniques;Collaborations;Communication;Complex;Computational Biology;CRISPR/Cas technology;Data;Dilated Cardiomyopathy;Disease;Endothelial Cells;endothelial dysfunction;env Gene Products;Environment;experimental study;familial dilated cardiomyopathy;Family;Functional disorder;Gene Deletion;Gene Expression;gene regulatory network;Genes;genome editing;Genomic DNA;Genotype;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Transplantation;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;insight;interdisciplinary approach;Kinetics;knock-down;Knowledge;lamin C;Lamin Type A;Ligands;loss of function;Lovastatin;Machine Learning;mechanical properties;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;next generation sequencing;novel;Nuclear Envelope;Oligonucleotides;Organ;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;Positioning Attribute;promoter;receptor;Research Proposals;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Site;sound;stem cell biology;Technology;Tissue Engineering;tool;transcription factor;translational medicine;Translational Research;Variant;Wing;Work;Zebrafish

PROJECT_TITLE: Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Cancer;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma (NHL), continues to be a leading cause of cancer-related death in HIV-infected individuals. Notably, those with DLBCLs that are infected with the opportunistic cancer-causing Epstein-Barr virus (EBV) suffer from worse overall survival compared to their EBV-negative counterparts – highlighting the importance of focusing on EBV-associated factors and pathways. In this application, we address how EBV rewires cellular DNA repair to make DLBCLs vulnerable to innovative synthetic lethal therapies with the ultimate goals of developing clinically actionable signatures to predict therapeutic responsiveness of individual tumors and improving outcomes for those with EBV+ HIV-DLBCL.

PI_NAMEs: BHADURI-MCINTOSH, SUMITA  (contact);MCINTOSH, MICHAEL T

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;antiretroviral therapy;Area;B-Lymphocytes;brca gene;cancer cell;Cancer cell line;Cancer Etiology;cancer specimen resource;Cell Line;Cell Proliferation;cell transformation;Cells;Cessation of life;Cicatrix;clinical risk;clinically actionable;Data Set;Dependence;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA-Directed DNA Polymerase;Double Strand Break Repair;drug action;Ensure;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Exhibits;FDA approved;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genome;genome-wide;Goals;Herpesviridae;high risk;HIV;homologous recombination;Human;Human Herpesvirus 4;Immunocompromised Host;Impairment;improved outcome;in vivo;in vivo Model;Individual;inhibitor;innovation;insight;Investigation;Janus kinase;large cell Diffuse non-Hodgkin's lymphoma;Link;lymphoblastoid cell line;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;multiple omics;Mutation;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;Oncogenic;Oncogenic Viruses;Oncoproteins;Pathway interactions;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;predicting response;predictive marker;predictive signature;Predisposition;Process;Proliferating;Property;Regimen;repaired;Research;response;S phase;Shapes;Stat3 protein;targeted agent;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Transcript;transcription factor;transforming virus;Translating;tumor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Alcohol use is a common risk factor for both HIV acquisition and poor uptake and use of effective biomedical HIV prevention options, including pre- and post-exposure prophylaxis, in sub-Saharan Africa. Moving HIV services out of health facilities and into community settings is a key innovation that has increased reach and engagement in HIV testing and treatment services, but remains underdeveloped for biomedical HIV prevention services. This K24 award will support Dr. Chamie by providing him protected time to mentor early career researchers with an interest in patient-oriented research at the intersection of HIV prevention and alcohol use, including community-based HIV prevention for adults at alcohol drinking venues, in East Africa.

PI_NAMEs: CHAMIE, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: 2019-nCoV;Address;Adherence;Adult;Africa;Africa South of the Sahara;African;AIDS prevention;Alcohol abuse;Alcohol consumption;alcohol misuse;Alcohols;arm;Attention;Award;Awareness;California;career;career development;Caring;Clinic;Clinical Trials;Collaborations;Communicable Diseases;Communities;community intervention;community setting;Community Trial;Consumption;cost;Counseling;Country;drinking;Educational workshop;Effectiveness;experience;Facility Accesses;Faculty;female sex worker;Future;Goals;health care availability;Health care facility;Health Personnel;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV/TB;Hot Spot;human centered design;Human immunodeficiency virus test;implementation framework;implementation outcomes;improved;Incidence;Infrastructure;innovation;interest;Intervention;intervention delivery;Interview;Kenya;Measures;Medical;Medical Research;Medicine;member;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;novel;outreach;patient oriented;patient oriented research;Perception;person centered;Persons;Physicians;pilot test;pilot trial;Play;Population;postdoctoral investigator;pre-doctoral;pre-exposure prophylaxis;preference;Prevalence;Prevention;Prevention approach;prevention effectiveness;Prevention Research;prevention service;preventive intervention;primary outcome;programs;Prophylactic treatment;prototype;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Risk;Risk Factors;Role;Rural;San Francisco;service delivery;Services;sex;Site;social stigma;Surveys;testing services;therapy development;Time;Training;transactional sex;transmission process;treatment services;Uganda;Universities;Unsafe Sex;uptake;Viral;Work

PROJECT_TITLE: Mentorship in patient-oriented research to optimize community-based HIV prevention for adults at high-risk of HIV at alcohol drinking venues in East Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

PHR: Health Relevance/Narrative: There is growing evidence that cellular senescence plays a critical role in the pathogenesis of chronic liver diseases. Our studies will dissect the role of the activin A/p15INK4b axis in inducing senescence and how it impacts chronic liver disease progression. Uncovering mechanism(s) and identifying essential mediators of hepatocyte senescence will provide fundamental new information for developing novel therapeutic strategies to halt progression of chronic liver diseases.

PI_NAMEs: OERTEL, MICHAEL  (contact);RAEMAN, REBEN

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: activin A;Alcoholic Liver Diseases;Animal Model;antagonist;autocrine;Automobile Driving;beta-Galactosidase;bile duct;Cell Aging;Cell Cycle Arrest;Cells;Chemicals;chemokine;chronic liver disease;Cirrhosis;Clinical;clinically relevant;comparative;Confocal Microscopy;cytokine;Data;Disease Progression;DNA Damage;experience;experimental study;Fibrosis;Functional disorder;Genes;Growth;Growth Factor;Health;Hepatic;Hepatocyte;Hepatocyte transplantation;Human;Immune;immune cell infiltrate;Immunology;Impairment;In Vitro;in vivo;Inflammation;inhibitor;insight;Investigation;Knowledge;laser capture microdissection;Ligation;Light;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Mediating;Mediator;Metabolic;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;Oncogene Activation;overexpression;paracrine;Paracrine Communication;Pathogenesis;Pathology;Patients;Peptide Hydrolases;permissiveness;Phenotype;Play;Population;prevent;Publishing;Rattus;Reporting;Reproducibility;response;Rodent;Rodent Model;Role;senescence;senescence associated secretory phenotype;senescent cell;Stimulus;System;telomere;Testing;Therapeutic;Thioacetamide;Tissues;transcriptome sequencing;transplant model;vector induced

PROJECT_TITLE: Blocking hepatocyte senescence as a novel therapeutic strategy for chronic liver diseases

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Voltage-gated calcium ion channels are the gatekeepers that sit at the junction of the peripheral and central nervous systems. Our research is focused on the importance of these channels in normal and abnormal pain. We hope to generate new strategies to mitigate some forms of chronic pain experienced by millions of people.

PI_NAMEs: LIPSCOMBE, DIANE  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: access restrictions;Address;Afferent Neurons;Architecture;Behavior;Behavioral;Binding;Binding Proteins;bisulfite sequencing;Brain;Calcium;Calcium Channel;Calcium Signaling;Capsaicin;CCCTC-binding factor;Cell Line;Cells;Central Nervous System;Chromatin;chronic pain;chronic painful condition;Collaborations;defined contribution;Detection;Disease;DNMT3a;Enzymes;Epigenetic Process;Event;Exons;experience;experimental study;Functional disorder;Gatekeeping;Gene Chips;Genes;Genetic;genetic approach;Glutamates;healing;Hypersensitivity;improved;in vivo;in vivo calcium imaging;in vivo imaging;Inflammation;Injury;Investigation;Ion Channel;Link;Location;Maintenance;Mammalian Cell;Measures;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;Messenger RNA;Methodology;Methods;Methylation;Modeling;Molecular;Morphine;Mouse Strains;mRNA Precursor;Nerve;Nerve Endings;nerve injury;Nervous System;Neurons;Neurosciences;neurotransmission;Nociception;Nociceptors;novel;optogenetics;P-Q type voltage-dependent calcium channel;Pain;pain model;pain perception;Pattern;Peripheral;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System;Persons;pharmacologic;Pharmacology;presynaptic;Process;Property;Protein Isoforms;Proteins;Research;response;RNA;RNA Splicing;Role;Sensory;sensory system;Signal Transduction;Site;Skin;Specificity;Spinal cord posterior horn;Stimulus;Substance P;Synapses;synaptic function;Testing;tissue injury;Touch sensation;transmission process;treatment strategy;United States;voltage;Zinc Fingers

PROJECT_TITLE: Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Patient Safety;Pediatric;Rural Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Consent, assent, and decision-making are regularly encountered in the clinical and research settings but can be stymied in youth and adults with Down syndrome (DS) because of their intellectual disabilities, their receptive and expressive communication differences, and their providers' and potential research partners' limited expertise in the self-efficacy arena. This national patient-centered study seeks input from a diverse group of people with DS and caregivers on the use of multi-media materials to promote understanding/ appreciation of study purpose, procedures, risks/benefits and will be complemented by discussions surrounding decision-making involvement.

PI_NAMEs: KELLY, ANDREA BRIDGET (contact);MILLER, VICTORIA ALLISON

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adult;Advocate;Age;Area;Benefits and Risks;Caregivers;Child;Child Development;Chronic;Clinical;Clinical Research;clinical trial readiness;cognitive ability;cohort;Collaborations;Communication;Communication Barriers;Comprehension;Consent;Country;Creativeness;Data;Decision Making;decision research;demographics;design;Development;digital applications;disability;Disparity;Down's Syndrome;Education;Educational Materials;Elements;Enrollment;Ethnic Origin;Exclusion;experience;Faculty;Family;Family Research;Feedback;Fostering;Friends;Geographic Locations;Health;Home;human subject protection;Human Subject Research;Individual;Informed Consent;Infrastructure;Intellectual functioning disability;interest;Intervention;Interview;Investigation;Learning;life span;Limited English Proficiency;Medical;Methodology;Modeling;Morals;multidisciplinary;Multimedia;Neurocognitive Deficit;Paper;Parents;Participant;patient oriented;Patient Outcomes Assessments;Patients;Pediatric Hospitals;Performance;Persons;Philadelphia;Population Heterogeneity;Procedures;Process;process optimization;programs;Protocols documentation;Provider;Questionnaires;Race;recruit;Regulation;Research;Research Institute;Research Methodology;Research Personnel;Risk;Role;Rural;rural environment;Sampling;Self Efficacy;Services;Sleep;Sleep Apnea Syndromes;social;Spanish;Structure;Techniques;Testing;Text;tool;Training;Translating;Translations;trial comparing;Update;urban setting;verbal;virtual;Visual;Voice;Vulnerable Populations;web app;Work;Writing;young adult;Youth

PROJECT_TITLE: Leveraging E-education to Advance Assent and Decision-Making Involvement in Down Syndrome


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Assistive Technology;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Osteoarthritis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Every year, nearly 400,000 Americans rupture their anterior cruciate ligament and more than half of them develop post-traumatic osteoarthritis (PTOA) within 15 years. By objectively capturing movement during both natural environment ambulation and physical therapy, the proposed research will inform the development of more effective rehabilitation therapies assisted by wearable technology and computer vision/machine learning, promising to halt PTOA and extend the lifespan of natural joints.

PI_NAMEs: HALILAJ, ENI  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Age;Algorithms;American;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Arthritis;auditory feedback;Biofeedback Training;Biological Markers;Biomechanics;Body mass index;Caring;Cartilage;Cellular Phone;Characteristics;Clinic;clinical care;clinical translation;Clinical Trials;Computer Vision Systems;computerized tools;Data;Development;Devices;Digital biomarker;Early treatment;Environment;Exercise;Exhibits;extend lifespan;Failure;Feedback;flexibility;Future;Gait;gait examination;gait rehabilitation;gait symmetry;Goals;haptic feedback;haptics;Health;Health Technology;High Prevalence;Home;improved;individualized medicine;Injury;innovation;Joints;Knowledge;Laboratories;Laboratory Research;light weight;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Measures;Modernization;Monitor;Movement;multimodality;Operative Surgical Procedures;Orthopedics;Patients;Performance;personalized intervention;Physical assessment;Physical therapy;portability;post-operative rehabilitation;Postoperative Period;Prevention;Primary Prevention;Radiology Specialty;Reconstructive Surgical Procedures;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;restoration;Risk;Role;Rupture;sensor;sex;skin patch;SMART health;Sports;Structure;System;Techniques;Technology;Thigh structure;Time;Traumatic Arthropathy;Travel;Vertebral column;Vision;visual feedback;Wearable Computer;wearable data;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Digital Biomarkers of Post-traumatic Osteoarthritis: Toward Precision Rehabilitation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our effort would address key existing knowledge gaps in global psychosis-risk research, and provide insights into ethnic heterogeneity of clinical outcomes in high risk youth. By building capacity in clinical, MRI and EEG research in Kenya, we will facilitate sub-Saharan Africa joining future international research efforts.

PI_NAMEs: MAMAH, DANIEL  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adolescent and Young Adult;Affective Symptoms;Africa;Africa South of the Sahara;African;aged;Asia;Attenuated;Auditory;Australia;behavioral outcome;Biological Markers;Bipolar Disorder;blood oxygenation level dependent imaging;Brain;brain behavior;Brain Diseases;brain magnetic resonance imaging;Brain Mapping;Clinical;clinical effect;clinical heterogeneity;clinical high risk for psychosis;clinical risk;Clinical Trials;clinically relevant;Cognition;Cognitive deficits;cohort;Computer software;Country;Data;Delusions;Development;diagnostic strategy;Diffusion;Early identification;early psychosis;Early treatment;effective therapy;Electroencephalography;Electrophysiology (science);EP300 gene;equipment acquisition;Ethnic Origin;Ethnic Population;Europe;experience;frontal lobe;functional decline;Functional impairment;functional improvement;Functional Magnetic Resonance Imaging;Funding;Future;Genetic;Goals;Hallucinations;healthy volunteer;Heterogeneity;high risk;high risk population;Human Resources;Hydrocortisone;Image;imaging capabilities;Individual;Infrastructure;insight;International;Intervention;Kenya;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Maps;Measures;Methods;multimodality;Nerve Degeneration;neuroimaging;North America;Oceania;Outcome;Outcome Study;Participant;Pathogenicity;Patients;personalized medicine;Persons;Population;predictive marker;Prognostic Marker;Psychopathology;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Research;Research Training;Risk Reduction;risk variant;Sampling;Schizoaffective Disorders;Schizophrenia;Site;Slice;Structure;Syndrome;Testing;Thinness;Time;Training;Training and Infrastructure;United States National Institutes of Health;Variant;Work;Youth

PROJECT_TITLE: Clinical and Biomarker-Based Trajectories of Psychosis-Risk Populations in Kenya


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_DEPT: NEUROSURGERY

PHR: Narrative Diet-induced obesity (DIO) is the most common form of obesity in humans. This research project will test a novel concept that truncated TrkB receptors (TrkB.T) in astrocytes play a critical role in the development of DIO. Our studies will likely show that attenuating TrkB.T-mediated Ca2+ signals in astrocytes can be a novel and effective strategy for therapeutic interventions of DIO.

PI_NAMEs: XU, BAOJI  (contact);YANG, YUNLEI

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Age;antagonist;Astrocytes;astrogliosis;attenuation;Axon;Binding;Brain;Brain region;Brain-Derived Neurotrophic Factor;Ca(2+)-Transporting ATPase;Cell membrane;Cells;conditional knockout;density;Development;diet-induced obesity;Dimerization;energy balance;Energy Intake;Energy Metabolism;excitotoxicity;experimental study;Fat-Restricted Diet;feeding;Gene Deletion;Glutamates;Growth;High Fat Diet;Homeostasis;Human;Hyperactivity;Hyperphagia;Hypothalamic structure;Impairment;Injections;Inositol;ITPR1 gene;knock-down;Knock-out;Knockout Mice;Lead;Length;Measures;Mediating;Minor;Morbid Obesity;Morphology;Mus;Mutation;Nerve Degeneration;neuron development;neuronal survival;Neurons;neurotoxic;neurotransmission;Neurotransmitters;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;NTRK2 gene;Nutritional;Nutritional Support;Obesity;obesity prevention;Phosphotransferases;Play;prevent;Process;Protein Isoforms;receptor;Reducing diet;Regulation;Reporting;Research Project Grants;Resistance;response;rho GTP-Binding Proteins;RNA Splicing;Role;Signal Pathway;Signal Transduction;Site;Slice;Structure;Structure of nucleus infundibularis hypothalami;Synapses;Synaptic Cleft;Synaptic Transmission;Testing;Therapeutic Intervention;transmission process;tripolyphosphate;Tropomyosin;Tyrosine Kinase Domain;uptake;Variant

PROJECT_TITLE: Astrocytic regulation of energy balance on high-fat diet

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Our ability to precisely target human disease relies on knowing what genes in what cells are dysregulated, yet current approaches using bulk tissue often lack cell-type information. We will develop innovative methods to identify disease-associated gene-cell pairs by integrating large-scale molecular data of patient and cell cohorts. The proposed approaches can be applied across human diseases to find new diagnostic markers and treatment targets.

PI_NAMEs: HUANG, KUAN-LIN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Affect;Algorithms;Automobile Driving;Biological;causal variant;Cell Separation;cell type;Cells;Chromosome Mapping;cohort;Complex;Data;design;Development;diagnostic biomarker;diagnostic strategy;Disease;disease phenotype;DNA sequencing;empowerment;epigenome;epigenomics;Etiology;Foundations;gene discovery;Genes;genetic variant;genome wide association study;Genomics;human disease;innovation;Investigation;large scale data;Masks;Methods;molecular scale;multiple omics;novel diagnostics;Patients;Population;programs;Proteome;Research;Signal Transduction;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translating;treatment strategy

PROJECT_TITLE: Integrative Approaches for Identifying Causal Gene-Cell Type Pairs of Complex Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Insufficient sleep is a prevalent health issue that is associated with metabolic, psychiatric, and neurodegenerative diseases and disorders among others. Understanding the role of different types of brain cells in the regulation of sleep and wakefulness is fundamental to understanding the cellular and molecular basis of normal and disordered sleep. This proposal focuses on identifying how non-neuronal brain cells (i.e. astrocytes) interact with neurons to regulate sleep need.

PI_NAMEs: INGIOSI, ASHLEY MIRANDA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Address;Architecture;arm;Arousal;Astrocytes;awake;Behavior;Biological;Brain;brain cell;BRAIN initiative;Calcium;Calcium Signaling;cell type;Cells;Cognition;Connexins;Disease;Electric Stimulation;Electroencephalography;Electromyography;Event;Feedback;Frequencies;frontal lobe;Future;Gap Junctions;Goals;Health;Homeostasis;Image;Impairment;in vivo calcium imaging;innovation;Investigation;Link;link protein;Liquid Chromatography;locus ceruleus structure;Measures;Mediating;Mental disorders;Metabolic;Metabolic Diseases;Methods;Microscope;Molecular;Monitor;multimodality;Mus;Mutant Strains Mice;Neurodegenerative Disorders;Neuroglia;Neurons;neurotransmission;Neurotransmitters;non rapid eye movement;Norepinephrine;optogenetics;Pathway interactions;Performance;Phosphoproteins;Phosphorylation;Physiological;poor sleep;Post-Translational Protein Processing;Process;Proteins;Proteomics;receptor;Recovery;Regulation;response;Rest;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Protein;Sleep;sleep abnormalities;Sleep Deprivation;Sleep Disorders;sleep physiology;sleep regulation;Slow-Wave Sleep;Synapses;System;tandem mass spectrometry;Testing;theories;Time;United States;Wakefulness;Wild Type Mouse

PROJECT_TITLE: Dissecting the role of neuronal-astroglial interactions in sleep homeostasis


NIH_SPENDING_CATS: Asthma;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Despite a strong evidence-base for the efficacy of asthma care intervention programs in reducing asthma morbidity among low-income minority children, gaps remain in our understanding of how best to translate and scale up these efficacious interventions into sustainable, broad-based programs that reduce known asthma health disparities. This proposal seeks to evaluate the implementation of a multi-level Head Start education program identify innovative methods for implementation and sustainability in low resource settings by partnering with YMCA Maryland Head Start programs.

PI_NAMEs: EAKIN, MICHELLE NUTTALL (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Address;Adherence;Adoption;Adrenal Cortex Hormones;Agreement;Asthma;Baltimore;care coordination;Caring;Characteristics;Child;Child Development;Child Welfare;Cities;Communities;community organizations;Consolidated Framework for Implementation Research;County;Data;design;Education;effective intervention;Effectiveness;efficacious intervention;Evaluation;evidence base;Evidence based intervention;Evidence based program;Family;Focus Groups;Frequencies;Government Agencies;Guidelines;Head Start Program;Health;health care service utilization;health disparity;Human Resources;implementation determinants;implementation evaluation;implementation facilitators;implementation outcomes;implementation process;implementation strategy;improved;Individual;innovation;integrated care;Intervention;intervention mapping;intervention program;Knowledge;Learning;Link;Low income;Maryland;Measures;Medical;Methods;minority children;Morbidity - disease rate;Nursery Schools;Oral;organizational readiness;Outcome;Penetration;Pharmaceutical Preparations;Phase;physical conditioning;primary care provider;Program Sustainability;programs;Provider;Research;Resource-limited setting;Resources;Risk;satisfaction;scale up;Schools;screening;Self Efficacy;Self Management;Services;Site;success;Surveys;Symptoms;systematic review;Theory of Change;Training;Training and Education;Translating;Variant

PROJECT_TITLE: Implementation of a multilevel program to reduce asthma symptoms in urban preschoolers


NIH_SPENDING_CATS: Natural Products

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This proposal outlines plans for the development of new methods and general strategies for chemical synthesis of complex, bioactive organic compounds. The results from this endeavor will produce new synthesis “tools” that will enable medicinal chemists in academia, government labs, and the pharmaceutical industry to more easily access intricate molecules that are needed for biomedical studies and for the development of pharmaceutical drugs. The challenging projects that will be examined will provide excellent problem-solving skills and training in synthetic organic chemistry for graduate students and postdoctoral associates and prepare them for careers in biomedical fields.

PI_NAMEs: RAWAL, VIRESH H. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Academia;Address;Alkaloids;bioactive natural products;Biological Testing;career;Catalysis;Cations;chemical synthesis;Chemistry;Claisen rearrangement;Communities;Complex;cycloaddition;Cycloheptanes;design;Development;Development Plans;drug development;Drug Industry;Family;Funding;Goals;Government;graduate student;Indole Alkaloids;Indoles;indoline;innovation;interest;Investigation;Medicine;member;Methodology;Methods;Natural Products;novel;Organic Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;Postdoctoral Fellow;Preparation;Problem Solving;Process;programs;Reaction;Research;Route;screening;Skeleton;skills;Structure;tool;Training;undergraduate student;Work

PROJECT_TITLE: New Methods and Strategies for the Concise Synthesis of Complex Indole Alkaloids

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The aims of the project are: 1) to continue the ongoing studies of the current Gastroparesis Clinical Research Consortium into the new funding period and 2) to assess the efficacy of balloon dilation of the pylorus in patients with gastroparesis and functional dyspepsia defined by measures of gastric myoelectrical activity, accommodation, antro-pyloric pressure and pyloric distensibility. Understanding subtypes of gastroparesis and functional dyspepsia based on gastric pathophysiology will improve selection of patients and treatment outcomes for patients with gastroparesis and functional dyspepsia.

PI_NAMEs: MOSHIREE, BAHARAK  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Aftercare;Antral;associated symptom;Balloon Dilatation;Biological Specimen Banks;Biopsy;Buspirone;Characteristics;Clinical;clinical center;Clinical Research;cohort;Collection;Databases;Diagnostic;Disease;double-blind placebo controlled trial;Dyspepsia;Dysthymic Disorder;early satiety;efficacy evaluation;Endoscopy;Etiology;follow-up;Functional disorder;Funding;Gastric Emptying;Gastroparesis;Genetic;GPR4 gene;improved;improved outcome;Interstitial Cell of Cajal;Laboratory Study;Measures;Mission;Molecular;Motility;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;neuromuscular;Operative Surgical Procedures;optimal treatments;Oral;Pathogenesis;Pathologic;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Physiological;Physiology;Placebo Control;Placebos;pressure;Protocols documentation;Pyloric sphincter structure;pyloroplasty;Pylorus;Questionnaires;Randomized;reduce symptoms;Registries;response;Role;Safety;Satiation;Single-Blind Study;Site;Sphincter;Stomach;symptom treatment;Symptoms;Testing;Therapeutic;Thick;treatment comparison;Treatment outcome;Visit;volunteer;Water

PROJECT_TITLE: Exploration of Subtypes of Gastroparesis and Gastroparesis-like Symptoms based on Physiological Testing


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Most research to date has focused on transcriptional, epigenetic, electrophysiological and morphological adaptations within neurons to understand drug addiction and relapse. The experiments described in this proposal seek to elucidate important changes occurring in a less well-studied cell type, the astrocyte, and are supported by my recent data that demonstrate a dynamic role for astrocytes within the brain reward circuitry during heroin relapse. The proposed research will address the mechanisms by which astroglial plasticity is triggered by and associates with the local circuitry to attenuate cue-induced heroin seeking and provide me with training in techniques required to more clearly define the role of astrocytes in shaping neural signaling during drug relapse.

PI_NAMEs: KRUYER, ANNA K (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;Actin-Binding Protein;ADRBK1 gene;Animal Model;Astrocytes;Attenuated;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Brain;cell type;Cells;Chronic;Clinical;Complement Receptor;Confocal Microscopy;Corpus striatum structure;Cues;Data;Diffusion;Dissection;Dopamine;Dopamine D1 Receptor;Drug Addiction;drug craving;drug relapse;drug seeking behavior;Drug usage;effective therapy;Electrophysiology (science);Epigenetic Process;Event;experience;experimental study;Exposure to;Extinction;extracellular;ezrin;Fiber;G protein coupled receptor kinase;Genetic Transcription;Glutamate Transporter;glutamatergic signaling;Glutamates;Goals;Halorhodopsins;Heroin;heroin use;Homeostasis;Human;in vivo;insight;knock-down;Label;Link;link protein;Literature;Measures;Mediating;Membrane;Morphology;Motility;motivated behavior;neural;neural circuit;neural model;neuroadaptation;Neurons;neuropsychiatric disorder;neurotransmission;novel;Nucleus Accumbens;Opioid;Opsin;optogenetics;Outcome;Output;Pathway interactions;Peripheral;Pharmaceutical Preparations;Phosphorylation;Photometry;Physiology;Population;postsynaptic;Pre-Clinical Model;Process;Production;prolonged abstinence;protein expression;Proteins;Publishing;Rattus;Relapse;Research;response;reward circuitry;Rewards;Role;selective expression;Self Administration;sensor;Shapes;short hairpin RNA delivery;Signal Transduction;small hairpin RNA;Sucrose;Surface;Synapses;Synaptic Transmission;Techniques;Time;tool;tool development;Training;Transgenic Organisms;transmission process;uptake;Viral;Withdrawal;Work

PROJECT_TITLE: Circuit-Selective Astroglial Plasticity During Opioid Relapse

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Project Narrative Cancer immunotherapies are often focused on activating of engineering a subset of T cells that exhibit selective recognition of Class I or Class II tumor neoantigens. We propose to develop an integrated nanotech, biomolecular engineering, and microtech suite of tools towards identifying and characterizing CD4+ and CD8+ T cell responses against neoantigen, with a focus on those neoantigens that have the potential to be presented by every cancer cell in a tumor. The proposed methodology, as well as data set, will be of high value to the fundamental and clinical immuno-oncology communities.

PI_NAMEs: HEATH, JAMES R. (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Algorithms;alpha-beta T-Cell Receptor;Antigen Presentation;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;Artificial nanoparticles;Binding;Blood;Bypass;cancer cell;cancer immunotherapy;CCNE1 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clinic;Clinical;Clone Cells;colon cancer patients;Community Clinical Oncology Program;cost;Cost Savings;COVID-19 patient;current pandemic;Data;Data Set;design;design and construction;Disadvantaged;Engineering;Exhibits;Funding;Genes;Genetic Engineering;Grant;Haplotypes;Heart;Histocompatibility Antigens Class II;Immunooncology;Immunotherapy;Infusion procedures;innovation;invention;KRAS2 gene;Length;Libraries;Malignant neoplasm of ovary;Methodology;Methods;MHC Class II Genes;microchip;mutant;Mutate;Mutation;nano;Nanotechnology;neoantigens;Oncogenes;pandemic disease;Patients;Peptides;Peripheral Blood Mononuclear Cell;Population;prediction algorithm;Preparation;Protein Engineering;Proteins;Protocols documentation;public database;Reagent;Reporting;Resources;Specificity;T cell response;T cell therapy;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;Time;tool;TP53 gene;Transfection;tumor;Tumor Antigens;Validation;Work

PROJECT_TITLE: Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The goal of this project is to improve the understanding of how antibodies associated with a dangerous clotting condition called heparin-induced thrombocytopenia/thrombosis (HIT) cause the complications seen in this disease. Insights gained from this work are expected to lead to the development of better ways to diagnose and treat HIT.

PI_NAMEs: PADMANABHAN, ANAND  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: accurate diagnosis;Affect;Alpha Granule;American Society of Hematology;Antibodies;Anticoagulant therapy;Anticoagulants;Anticoagulation;Antigens;Area;Benign;Binding;Biochemical;Biological Assay;Blood Platelets;Blood specimen;Cessation of life;Characteristics;Chondroitin Sulfate A;Chondroitin Sulfates;Chromatography;Coagulation Process;Complex;Dangerousness;Data;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;Disease;drug candidate;Early Diagnosis;Environment;Enzyme-Linked Immunosorbent Assay;Epidemic;Evaluation;Event;Functional disorder;Generations;Goals;Hemorrhage;Heparin;Heparin Binding;heparin-induced thrombocytopenia;Heterogeneity;Hospitals;improved;In Vitro;in vivo;Incubated;inhibitor;innovation;insight;Institution;Laboratories;Length;Life;Mediating;Methods;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;murine monoclonal antibody;new therapeutic target;novel;novel strategies;Outcome;P-Selectin;Pathogenesis;Pathogenicity;Pathway interactions;Patients;PF4 Gene;Platelet Activation;prevent;Proteins;rapid diagnosis;Research;Research Infrastructure;Research Personnel;Risk;Sampling;Serology;Serotonin;Specificity;Sulfate;Surface;Syndrome;Testing;Therapeutic;Thrombin;Thrombocytopenia;Thrombosis;Time;Whole Blood;Work

PROJECT_TITLE: New approaches to the pathophysiology, diagnosis and management of heparin-induced thrombocytopenia