ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE Large disparities in the number of underrepresented students pursuing careers in biomedical science still exist. The Monell Science Apprenticeship Program (MSAP) 2.0 strives to positively influence the science career decisions of students from underrepresented backgrounds who represent different genders, economic strata, races, ethnicities, and physical and mental abilities. By completing the work outlined in this proposal, we will both foster diversity in biomedical research and inspire and prepare the next generation of scientists to make meaningful contributions to the field.

PI_NAMEs: MAINLAND, JOEL D (contact);PARMA, VALENTINA

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Adult;Affect;Affinity;Ageusia;Analytical Chemistry;Animal Experimentation;Animals;apprenticeship;Area;Award;Bachelor's Degree;Biomedical Research;biomedical scientist;career;Career Choice;Censuses;Chemicals;cohort;college;Communication;COVID-19;Creativeness;disadvantaged student;Discipline;Disparity;Economics;Educational Curriculum;Educational process of instructing;efficacy evaluation;Electrophysiology (science);Ensure;equity, diversity, and inclusion;Ethics;Ethnic Origin;Evaluation;Event;Exhibits;experience;Faculty;Family;Fostering;Friends;Future;Gender;General Population;Genetic;Goals;Growth;Health;high school;High School Student;Human;improved;Inequality;innovation;insight;Institution;Instruction;International;Interview;Investments;lectures;Letters;Master of Science;matriculation;meetings;member;Mentors;Mentorship;Methods;Mission;Molecular Biology;Monitor;next generation;Oral;outreach;Participant;peer;Personal Satisfaction;Philadelphia;Population;Positioning Attribute;Postdoctoral Fellow;postgraduate education;prevent;Process;Program Evaluation;programs;Psyche structure;Psychophysics;Public Speaking;Race;Recording of previous events;recruit;Reduce health disparities;Research;Research Activity;Research Training;responsible research conduct;Running;Science;Scientific Advances and Accomplishments;Scientist;Sensory;skills;Smell Perception;Sorbus;Structure;Student recruitment;Students;success;Surveys;symposium;Taste Perception;teacher;Testing;Time;Training;undergraduate education;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: Monell Science Apprenticeship Program: Inspiring Biomedical Careers In Underrepresented Undergraduates

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (46)]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The goal of this project is to evaluate a new method by the subconjunctival injection of DSP nanoparticles for treating nitrogen mustard (NM)-induced corneal injury. Therapeutic interventions to treat NM-induced ocular injury has not been identified yet, which highlights the need to develop new treatment options for vesicants- induced corneal injury. The sustained releasing DSP-PLA-NP could be effective in preventing corneal NV, corneal ulceration, corneal opacity, suppressing inflammatory and angiogenic markers after NM exposure.

PI_NAMEs: XU, QINGGUO  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;allograft rejection;analog;Animals;autoimmune uveitis;Biological Availability;Biological Markers;Blindness;Bulla;Chemical Agents;chemical threat;Chemical Warfare;Chronic;clinical translation;Cornea;corneal allograft;Corneal edema;Corneal Injury;Corneal Neovascularization;Corneal Opacity;Corneal Ulcer;Development;Dexamethasone;Dose;Doxycycline;Drops;drug release profile;early onset;effective therapy;efficacy evaluation;efficacy study;Exhibits;Exposure to;Eye;Eye Infections;Eye Injuries;Eyedrops;FDA approved;fighting;Formulation;Frequencies;Future;Glycolates;Goals;Health;Human;hydroxypropyl-beta-cyclodextrin;improved;In Vitro;Inflammation;Inflammatory;Injections;Injury;Lung;Mechlorethamine;Methods;Methylcellulose;Modeling;Molecular;Morbidity - disease rate;Mustard Gas;nanoparticle;novel;novel strategies;Oryctolagus cuniculus;particle;Patient Compliance;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Poison;poly(lactic acid);prevent;Prevention;Rattus;Relapse;Reporting;retinal toxicity;severe injury;side effect;Skin;sodium phosphate;standard of care;Study models;Testing;Therapeutic;Therapeutic Intervention;Time;Topical application;Treatment Efficacy;Tween 80;Ulcer;United States National Institutes of Health;Vesicants;Water;wound healing

PROJECT_TITLE: DSP nanoparticles for treating nitrogen mustard induced corneal injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (54)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: ORLANDO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative While enzyme-linked immunosorbent assay (ELISA) is widely used in clinical laboratories for disease biomarker screening and quantification, substantially improving their limit of detection without adding complexity has been a grand challenge. The proposed research aims to overcome this challenge by developing a unique signal generation system for ELISA. If successful, this work will significantly advance ELISA technology, enabling it to detect biomarkers at minute concentrations.

PI_NAMEs: XIA, XIAOHU  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Antibodies;Benchmarking;Biological;Biological Assay;Biological Markers;Biosensing Techniques;Blood;Blood specimen;Buffers;cancer biomarkers;Cancer Model;Carcinoembryonic Antigen;Chemicals;Clinical;clinical diagnostics;Color;Complex;cost;Data;design;Detection;detection assay;detection limit;detection sensitivity;Devices;Diagnostic Reagent Kits;diagnostic technologies;Dimensions;Disease;disease model;Elements;Ensure;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;Exhibits;expectation;Generations;Horseradish Peroxidase;Human;improved;in-vitro diagnostics;innovation;Label;Laboratories;Life;Measures;milliliter;Modeling;nano;nanoparticle;novel;Oxytocin;Patients;peptide hormone;Performance;Peroxidases;Polymers;Preparation;Procedures;programs;Prostate-Specific Antigen;protein biomarkers;Reaction;Recovery;Reporting;Reproducibility;Research;screening;Screening for cancer;Signal Transduction;stability testing;Structure;success;Surface;System;Techniques;Technology;Testing;translational impact;Variant;Work

PROJECT_TITLE: Improving ELISA Technology using Ultra-efficient Peroxidase Mimics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This project will digitize the 1960 full-count Census and use the resulting microdata to complete the largest longitudinal data infrastructure in the United States. The new data resource will enable health scientists to use information on early-life and mid-life experiences—such as parental economic status, childhood environmental exposures, public policy, social institutions, neighborhood characteristics, housing conditions—to investigate of the health, well-being, and mortality of Americans over their lives and through generations.

PI_NAMEs: ALEXANDER, JOSEPH T. (contact);GENADEK, KATHERINE R

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Affect;Aging;American;Audience Research;Behavioral;Biological;Censuses;Characteristics;Child;Childhood;Communities;Data;data centers;Data Collection;Data Files;data infrastructure;data resource;Data Set;Demography;Development;Documentation;Economics;Education;Environment;Environmental Exposure;experience;functional status;Funding;Generations;Geography;Goals;Handwriting;Health;Healthcare;Household;Housing;Individual;Infrastructure;innovation;Institution;Investigation;Investments;late life;Life;Life Cycle Stages;Life Experience;Link;Location;longitudinal analysis;Longitudinal Studies;Medicaid;Mental Depression;Metadata;Methods;middle age;Modernization;mortality;Neighborhoods;Optics;Outcome;Personal Satisfaction;Policies;Population;population based;population health;Process;Public Policy;Recording of previous events;Records;Reproductive Health;Research;Research Personnel;Research Priority;residence;Resources;Respondent;Retirement;Sampling;Scientist;Series;social;social factors;Social outcome;Street Address;Surveys;System;Techniques;Technology;United States;Work;World War II

PROJECT_TITLE: New cross-sectional and longitudinal data for the study of aging:  1960 full-count U.S. Census

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Microbiome;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Previous reports demonstrated an aberrant accumulation of oral microbes in the gut of patients with colorectal cancer (CRC). However, how this ectopic gut colonization by oral microbes occurs and how this event with affects the pathogenesis of CRC remain poorly understood. This project will elucidate the mechanisms by which oral microbes colonize the gut and promote the development of CRC.

PI_NAMEs: KAMADA, NOBUHIKO  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Address;Affect;Bacteria;Biological;Biology;Cancer Etiology;Cancer Model;cancer therapy;Cessation of life;Chronic;cohort;Cohort Studies;Colitis associated colorectal cancer;Colon;colon cancer patients;colon tumorigenesis;Colorectal Cancer;colorectal cancer prevention;colorectal cancer treatment;Data;Development;dextran sulfate sodium induced colitis;Diet;disease phenotype;Distal;Early Diagnosis;Epithelium;Escherichia coli;Event;experimental study;fitness;Gastrointestinal Diseases;Gastrointestinal tract structure;genotoxicity;Goals;gut colonization;Human;Inflammation;Inherited;innovation;insight;Knowledge;Life Style;Microbe;microbial;microbiome research;Molecular;Morbidity - disease rate;mortality;mouse model;novel strategies;novel therapeutics;Oral;oral bacteria;Oral cavity;oral streptococci;pathobiont;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Periodontal Diseases;Periodontitis;Prevalence;prevent;Prevention;Reporting;Research;Risk;Risk Factors;Role;Testing;tumorigenesis;United States

PROJECT_TITLE: The oral-gut axis in colorectal cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The plasma levels of the blood clotting protein, Von Willebrand Factor, contribute to an individual’s risk of both bleeding or abnormal blood clotting. Most of the variation of plasma von Willebrand Factor levels in humans is determined by genetic variants. This project uses up to date synthetic DNA techniques to determine the effect of mutations in the VWF gene and loss of function in other secretory pathway genes on plasma VWF levels.

PI_NAMEs: DESCH, KARL C (contact);KRETZ, COLIN

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Anabolism;Automobile Driving;biological adaptation to stress;Biological Assay;Biology;Blood;Blood coagulation;Blood Coagulation Disorders;candidate identification;Cell Line;Cell model;Cell secretion;Cells;Chemicals;Circulation;Clinical;clinical diagnostics;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Confocal Microscopy;CRISPR screen;CRISPR/Cas technology;Data;Databases;Defect;Diagnosis;Disease;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Equilibrium;exome;experience;functional genomics;Funding;gene network;Gene Targeting;Genes;Genetic;genetic variant;genome sequencing;genome wide association study;genomic locus;glycosylation;Golgi Apparatus;Half-Life;Hemorrhage;Hemostatic function;Heritability;Human;improved;In Vitro;Individual;Inherited;innovation;Investigation;Ischemic Stroke;Knowledge;Label;Laboratories;Libraries;Link;loss of function;Maps;Metabolic Clearance Rate;Minority;Molecular;Molecular Chaperones;Molecular Genetics;molecular sequence database;Mutagenesis;Mutation;mutation screening;Myocardial Infarction;National Heart, Lung, and Blood Institute;Pathway interactions;Patients;Phenotype;Plasma;Population;programs;Proteins;Quality Control;Recording of previous events;Reporter;Research Personnel;Risk;Role;Science;Stroke;synthetic construct;System;Techniques;Testing;therapeutic target;Thrombosis;Transgenes;treatment response;Uncertainty;validation studies;Variant;variant of unknown significance;Vascular Diseases;Venous;venous thromboembolism;von Willebrand Disease;von Willebrand Factor;whole genome

PROJECT_TITLE: The Molecular Genetics of Von Willebrand Factor Secretion

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  We will implement the use of student health care professionals in the role of ‘clinical TAs’ in four required undergraduate biomedical design courses as well as develop training for student health professionals on design thinking and the work of biomedical engineers. By reversing the default approach of immersing BME students in health care settings, we expect to accelerate the development of design skills including how they gain understanding and insight from user interactions throughout the design process. We ground our approach in research on collaborative design to increase the skills of multiple stakeholder groups to effectively engage in team-based biomedical design that leads to better needs and solution identification. 2

PI_NAMEs: FERNANDEZ, TODD  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Address;Anesthesiology;Biomedical Engineering;Clinical;Collaborations;Data;design;Development;Documentation;Education;education research;Educational Curriculum;Educational process of instructing;Engineering;engineering design;Ensure;Environment;Evaluation;Exercise;experience;Funding;Future;Grant;health care settings;Health Occupations;Health Personnel;Health Professional;Healthcare;Immersion;improved;information gathering;innovation;insight;interdisciplinary collaboration;interest;Joints;Knowledge;Leadership;Learning;Medical;medical schools;Medical Students;Modeling;Nature;Peer Group;Perception;Physical therapy;Population;Preparation;Problem Solving;Process;programs;Research;Research Technics;Role;secondary outcome;skills;Social Perception;Source;student training;Students;Thinking;Time;Training;undergraduate student;user centered design;Work

PROJECT_TITLE: Immersing student health professionals in BME design classrooms

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (J1)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Olfactory networks are implicated in a number of neurological diseases including Alzheimer’s, Parkinson’s and epilepsy. Furthermore, SARS-CoV-2 has recently been identified inside piriform cortex of primates infected with COVID, and has been shown to impact olfactory cortical networks with human piriform cortex, a major focus of this grant. The research proposed in this grant aims to determine electrophysiological properties of networks involved in encoding features of odor stimuli, which will lead to better understanding of the brain areas involved in these neurological diseases.

PI_NAMEs: ZELANO, CHRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: 2019-nCoV;Alzheimer's Disease;Animals;Anterior;Area;Behavioral Paradigm;Brain;Chemical Structure;Chemicals;Chemistry;Code;Collection;dalton;Data;Disease;Dissociation;Electrophysiology (science);Environment;Epilepsy;Evolution;experimental study;free behavior;Frequencies;Grant;High Frequency Oscillation;Human;Human Activities;Implant;Link;Maps;Measures;Molecular;Molecular Structure;Names;Nervous System Disorder;neural;neural correlate;Neurodegenerative Disorders;novel;Odors;olfactory bulb;Olfactory Cortex;olfactory nuclei;Olfactory Pathways;Parkinson Disease;Perception;physical property;piriform cortex;Primates;Property;Proxy;Psychophysics;Research;Research Personnel;response;Rest;Rodent;SARS-CoV-2 infection;Scheme;sensory system;Smell Perception;Stimulus;Work

PROJECT_TITLE: Electrophysiological representations of odor in the human brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-T (02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

PHR: NARRATIVE Dr. Yu Wang and his colleagues use both animal models and resected human tissues to study the cellular and molecular mechanisms of mTORopathies-related epilepsy (e.g., focal cortical dysplasia type II), how the overexpression of complement component C3 disrupts the balance of excitation and inhibition, and whether C3 inhibition can modify disease progression and improve seizure outcomes.

PI_NAMEs: WANG, YU  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Amino Acids;Animal Model;Animals;Anticonvulsants;Architecture;Astrocytes;Astrocytosis;Biochemistry;Cell Lineage;cell type;Child;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complement Activation;complement C3 precursor;Cortical Dysplasia;Cortical Malformation;Data;Development;Disease;Disease Progression;Electrophysiology (science);Epilepsy;Epileptogenesis;Equilibrium;Evolution;excitatory neuron;Exhibits;Experimental Animal Model;experimental study;FRAP1 gene;Frequencies;Functional disorder;Genes;genetic approach;genetic manipulation;Gliosis;Growth Factor;hemimegalencephaly;Human;human tissue;Image;Impairment;improved;in vivo;inhibitor;Inhibitory Synapse;insight;Internal Ribosome Entry Site;Interneurons;Intractable Epilepsy;Investigation;Knock-in Mouse;Knowledge;Logic;LoxP-flanked allele;Mediating;Membrane;Microglia;Molecular;Molecular Genetics;Molecular Profiling;mTORopathies;Mutagenesis;mutant;Mutation;Neuronal Injury;Neurons;neurotoxic;novel;Oligodendroglia;Outcome;overexpression;Pathology;Pathway interactions;Patients;Phagocytosis;Population;precision medicine;Progressive Disease;Property;Resected;Role;Seizures;Signal Transduction;Somatic Mutation;Source;spatiotemporal;Specificity;Synapses;Technology;Testing;Time;Tissues;transcriptome sequencing;Treatment Failure

PROJECT_TITLE: Decoding the cellular and molecular mechanisms of epileptogenesis and disease progression in mTORopathies

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: Neurodevelopmental disorders, including microcephaly and autism, as well as neurodegenerative diseases, including Alzheimer’s, and cancer result in significant human suffering and impose significant annual costs on the US health care system and society as a whole. This proposal seeks to understand how diet influences neural stem cell proliferation decisions during development. Neural stem cells are the cells that make all the neurons in the brain.

PI_NAMEs: SIEGRIST, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;autism spectrum disorder;Award;Behavior;Brain;career development;Cell division;cell type;Cells;Complex;Consumption;cost;Cues;Dependence;Development;Diet;dietary;Disease;doctoral student;Drosophila melanogaster;Genetic;Goals;Healthcare Systems;Human;insight;Intrinsic factor;Location;Malignant Neoplasms;mature animal;Microcephaly;model organism;Molecular;Morphology;National Research Service Awards;nerve stem cell;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuroregulation;Nutrient;Nutrient availability;parent project;Pathway interactions;Population Heterogeneity;programs;Proliferating;Research;single cell sequencing;Societies;stem cell proliferation;Stem Cell Research;Students;Techniques;Time;Training;Work

PROJECT_TITLE: Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative  NMR spectroscopy provides a means to identify, observe, and study the interactions of molecules important to human health. The proposed acquisition of a new spectrometer at Vanderbilt University will support researchers in the chemical and biochemical sciences who are working to identify natural products, advance drug candidates, understand the toxicity of chemotherapeutics, and develop molecular probes. This new instrument will modernize NMR infrastructure on campus and assist in training a new generation of chemists and chemical biologists.

PI_NAMEs: SCHLEY, NATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 20 year old;Air;Biochemical;Catalysis;Cell Nucleus;Chemicals;cohort;Electronics;empowerment;experimental study;Gases;Health;Heteronuclear NMR;Human;Individual;instrument;instrumentation;Life;Maintenance;Modernization;Motivation;Natural product discovery;next generation;NMR Spectroscopy;Positioning Attribute;programs;Protons;Recording of previous events;Research;Research Personnel;Research Support;Sampling;Science;Services;small molecule;Techniques;Temperature;Time;tool;Tube;two-dimensional;Universities;Walking

PROJECT_TITLE: Acquisition of a 400 MHz NMR Spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Neurosciences;Patient Safety;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: To investigate the rapidly advancing ketamine landscape, this study will integrate data on 1) prescribing,  medical use, and misuse, 2) recreational use, and 3) population-level data on availability and adverse events  including poisonings and death. This will include monitoring of ketamine prescribing practices, availability via  legal and illegal channels, and drug diversion, with additional focus on patterns of illicit use among high-risk  populations. Results will inform policy to curb availability, as well as prevention, treatment, and harm reduction  efforts.

PI_NAMEs: PALAMAR, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: Address;Adult;Adverse effects;Adverse event;Advertising;Area;Asia;Behavioral;Biological Testing;Cannabis;Cessation of life;Characteristics;Clinic;Clinic Visits;Clinical;college;cost;Curiosities;Dancing;Data;data integration;Data Sources;Dissociative Anesthetics;drug efficacy;Drug usage;enantiomer;epidemiology study;Event;experience;Exposure to;FDA approved;Fentanyl;fentanyl analog;Festival;Harm Reduction;high risk;high risk population;Home;Hour;Iatrogenesis;Individual;Internet;Ketamine;Label;Legal;Link;Medical;Medical Staff;Mental Depression;Mental Health;Monitor;Morbidity - disease rate;mortality;multidisciplinary;New York City;nonmedical use;off-label use;Office Visits;Online Systems;Opioid;Outcome;Overdose;Participant;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;Physicians;Poisoning;Policies;Population;Populations at Risk;Prevalence;Prevention;Psychiatry;Recreation;Reporting;Risk;Safety;saliva sample;salivary assay;Sampling;Seizures;Severities;side effect;Surveys;Testing;theories;Time;Toxicology;treatment-resistant depression;trend;university student;Visit;web site;Work

PROJECT_TITLE: Investigating the Ketamine Landscape: Availability, Medical and Recreational Use, and Effects

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE It is well-established that dysregulation of dopamine, noradrenaline, and serotonin signaling underlies many neurological and neuropsychiatric disorders, but there are fundamental gaps in the understanding of the mechanisms that control the release of these chemicals in the brain and how these chemicals signal at the level of synapses. The proposed research is relevant to public health because our incomplete understanding of the ion channels and circuits affected by dopamine, noradrenaline, and serotonin represents a key barrier to treating neuropsychiatric disorders (including cocaine use disorder), which currently lack efficacious therapeutics.

PI_NAMEs: GANTZ, STEPHANIE C. (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: 2-arachidonylglycerol;Action Potentials;Adrenergic Receptor;Affect;Antioxidants;ascorbate;Behavioral Assay;Brain;Calcium;Calcium Channel;Central Nervous System;chemical release;Chemicals;Cocaine;cocaine exposure;cocaine related behaviors;Cocaine use disorder;conditioned place preference;Coupled;Coupling;Cyclic AMP-Dependent Protein Kinases;Cysteine;Data;density;Development;disulfide bond;Dopamine;dopaminergic neuron;Dorsal;dorsal raphe nucleus;efficacious treatment;Electrophysiology (science);Etiology;extracellular;Fire - disasters;fluorescence imaging;Foundations;Future;G-Protein-Coupled Receptors;Generations;Glutamate Receptor;Glutamates;GTP-Binding Proteins;Hyperactivity;Image;in vivo;Individual;Ion Channel;Ions;Knock-out;Knowledge;Long-Term Depression;Long-Term Potentiation;Maintenance;Mediating;Membrane Potentials;metabotropic glutamate receptor type 1;Metabotropic Glutamate Receptors;Metals;Midbrain structure;Molecular;monoamine;Mus;Mutate;Nervous System Disorder;neuronal excitability;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurotransmitters;noradrenergic;Norepinephrine;novel;novel therapeutics;Orphan;Outcome;Oxidants;Oxidation-Reduction;pharmacologic;Pharmacology;Phosphatidylinositol 4,5-Diphosphate;Phospholipase C;Physiological;Play;postsynaptic;Proteins;Protons;Public Health;receptor;Receptor Gene;Reducing Agents;Regulation;Research;Resolution;response;Rest;Role;Second Messenger Systems;Serotonin;Side;Signal Transduction;Signaling Protein;Slice;Substance Use Disorder;Sulfhydryl Compounds;Synapses;Synaptic plasticity;System;Therapeutic;tool;Transition Elements;Vertebral column;voltage;Wild Type Mouse;Zinc

PROJECT_TITLE: Regulation of monoamine neurons by delta glutamate receptors

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: NARRATIVE The Center for Lung Biology and Disease was established through a Phase I Center of Biomedical Research Excellence award. Our Phase I proposal, aimed at providing Promising Junior Investigators (PJIs) an environment that maximizes their potential to contribute to advances in lung disease research, was successful in launching 6 new scientists in independent research careers. This Phase II proposal will continue programs established in Phase I, with an overarching goal of promoting research to unravel life-threatening respiratory diseases.

PI_NAMEs: CORMIER, STEPHANIA A;DUGAS, TAMMY R (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Advisory Committees;Air;Animals;Asthma;Award;Bioinformatics;Biology;Biomedical Research;career;Cell Nucleus;Cell Separation;Cells;Centers of Research Excellence;chemical release;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cigarette;cohort;Collaborations;Communicable Diseases;Communities;Complex;COVID-19 pandemic effects;Data;design;Development;Diabetes Mellitus;Disease;disease model;e-cigarette aerosols;Economic Development;Enhancement Technology;Environment;Environmental Exposure;experience;Extramural Activities;faculty research;Flow Cytometry;Fostering;Funding;Generations;Goals;Grant;Growth;Health;Healthcare;Human;Image;Immune;Immune response;Immunology;immunopathology;improved;Individual;Infection;Inhalation;Inhalation Exposure;Inhalation Toxicology;insight;Institution;Interdisciplinary Study;interest;International;Laboratory Animal Production and Facilities;Leadership;Life;Louisiana;Low Birth Weight Infant;low socioeconomic status;Lung;Lung Diseases;Mentors;Molecular and Cellular Biology;next generation sequencing;novel;Obesity;Pathogenesis;Pathway interactions;Personal Satisfaction;Phase;Pilot Projects;pollutant;Population;Positioning Attribute;prevent;Production;Productivity;programs;Public Health Informatics;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Respiratory Disease;Scientist;Series;Soil;Solid;Stimulus;Strategic Planning;Structure;Techniques;Therapeutic Agents;United States National Institutes of Health;Veterinary Medicine;Veterinary Schools;Viral;wasting;Water;Work

PROJECT_TITLE: Center for Lung Biology and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Lung

PI_NAMEs: DUGAS, TAMMY R (contact)

PROJECT_TERMS: Acute Lung Injury;Advisory Committees;Animals;Applications Grants;Asthma;Award;Biology;career;career development;Cellular biology;Centers of Research Excellence;Cigarette;Collaborations;college;Communities;comparative;Data;Development;Disease;e-cigarette aerosols;education research;Educational workshop;Ensure;Evaluation;Faculty;Fostering;Funding;Goals;Grant;immunopathology;improved;Infection;Infrastructure;Inhalation;instrumentation;Investments;Knowledge;Laboratories;Laboratory Research;Life;Louisiana;Lung;Lung infections;Mediating;Mentors;Mission;Molecular Biology;Outcome;Phase;Pilot Projects;Play;Positioning Attribute;Productivity;programs;Publications;Records;recruit;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Respiratory Disease;responsible research conduct;Role;Schools;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;stem;Stimulus;Structure;success;symposium;Technology;Training;undergraduate student;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools;Viral;web site;Work;Writing

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Lung

PI_NAMEs: YOSHIMURA, MASAMI  (contact)

PROJECT_TERMS: Acute Lung Injury;airway inflammation;Allergens;Animal Model;Award;Biology;Biomedical Research;Board Certification;Body Fluids;Breeding;Bronchoalveolar Lavage Fluid;Cell Culture Techniques;Cell Separation;Cells;Centers of Research Excellence;chemokine;Cigarette;Collaborations;Communities;Complex;Computer software;Consult;Consultations;Containment of Biohazards;Contract Services;cytokine;Data;Development;Disease;e-cigarette aerosols;Educational workshop;Ensure;Enterobacteria phage P1 Cre recombinase;Enzyme-Linked Immunosorbent Assay;Equipment;Evaluation;experience;Experimental Designs;Extrinsic asthma;Faculty;Faculty Recruitment;Flow Cytometry;Funding;Future;Genetic Engineering;Genotype;Goals;graduate student;Grant;Heart Rate;Histologic;Human Resources;Immune;Immunohistochemistry;Immunologic Techniques;Immunologics;Immunology;immunopathology;improved;In Situ Hybridization;in vitro Model;Inbred Mouse;Infection;Inflammation;Influenza;Institution;instrumentation;Knock-out;Laboratories;laser capture microdissection;lectures;Lesion;Life;Louisiana;Lung;Lung Diseases;Maintenance;Measurement;Measures;member;Microbe;Molecular;morphometry;Mus;operation;Organ;Outcome;Pathogenesis;Pathologic;Pathologist;Peer Review;Phase;Physiological;Pilot Projects;Postdoctoral Fellow;Productivity;programs;Publications;pulmonary function;Pulmonary function tests;Pulse Oximetry;Reagent;recruit;repaired;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Respiratory Disease;Secure;Serum;Services;Signal Transduction;Stains;Standardization;Stimulus;Students;success;Technical Expertise;Techniques;Temperature;tissue preparation;toxicant;Training;Transgenic Mice;Transgenic Organisms;Tuberculosis;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Pulmonary Immunopathology Core (PIP)


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Lung

ORG_DEPT: PATHOLOGY

PI_NAMEs: KOUSOULAS, KONSTANTIN G (contact)

PROJECT_TERMS: Acute Lung Injury;Address;Adopted;animal imaging;Antibody Formation;Bioinformatics;Biological;Biological Assay;Biology;Biometry;Biotechnology;Cells;Cellular biology;Centers of Research Excellence;Collaborations;Complex;Computers and Advanced Instrumentation;Confocal Microscopy;Core Facility;CRISPR/Cas technology;Data;Data Analyses;Development;Disease;Disease Outcome;Education;Electron Microscopy;Equipment;Experimental Designs;experimental study;Extrinsic asthma;Faculty;Faculty Recruitment;Fee-for-Service Plans;Funding;Gene Expression;Genomics;Genus Hippocampus;Human Resources;Immunofluorescence Microscopy;Immunologics;Immunology;improved;in vivo;Influenza;instrumentation;interest;Laboratories;light microscopy;Louisiana;Lung;Lung Diseases;Measurement;Measures;meetings;Mentors;Methodology;Methods;Microscopy;Molecular;Molecular Biology;Molecular Medicine;Monoclonal Antibodies;nano-string;new technology;Pathogenesis;Phage Display;Phase;Productivity;protein expression;protein purification;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Reagent;Research;Research Personnel;Research Project Grants;Resources;Reverse Transcriptase Polymerase Chain Reaction;Services;single cell sequencing;Students;success;Surface Plasmon Resonance;Techniques;Technology;Time;Tissue Sample;tissue/cell culture;Training;transcriptome sequencing;transcriptomics;Tuberculosis;United States National Institutes of Health;Update;Vendor;Veterinary Medicine;Veterinary Schools;Viral Vector

PROJECT_TITLE: Molecular and Cell Biology Core (MCBC)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Electronic Nicotine Delivery Systems;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Social Determinants of Health;Tobacco

PI_NAMEs: NOEL, ALEXANDRA  (contact)

PROJECT_TERMS: Address;Aerosols;Air;Air Pollutants;alveolar destruction;ambient air pollution;Animals;Area;Bacterial Pneumonia;Biological Assay;Biology;Blood;Bone Marrow Cells;carbapenem resistance;Cell Line;Cells;Centers of Research Excellence;Communicable Diseases;Computer Assisted;Data;Development;Disease;e-cigarette aerosols;Educational workshop;Electronic cigarette;Environment;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Equipment;experience;experimental study;exposure route;Exposure to;Funding;Future;Goals;graduate student;Hand;Human;immune function;In Vitro;in vitro Model;in vivo;Indoor Air Pollution;Infection;Infectious Agent;infectious disease model;Influenza A virus;influenzavirus;Inhalation;Inhalation Exposure;insight;Klebsiella pneumoniae;Life;Liquid substance;Lung;Lung Diseases;Lung infections;lung injury;Macrophage;Measurement;methicillin resistant Staphylococcus aureus;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;neutrophil;novel;Outcome;Particulate Matter;pathogen;Pathogenesis;Performance;Phase;Physiological;pollutant;Positioning Attribute;Postdoctoral Fellow;Predisposition;Principal Investigator;Prognosis;Public Health;Pulmonary function tests;Regulation;Research;Research Personnel;Research Support;resistant Klebsiella pneumoniae;Respiration;respiratory;Respiratory Disease;Respiratory Tract Infections;Risk;Science;second-hand cigarette smoke;Severities;simulation;Stimulus;Streptococcus pneumoniae;Structure of parenchyma of lung;System;Technology;Toxic effect;toxicant;Training;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Inhalation & Infection Core (IIC)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Rare Diseases

PI_NAMEs: BEAVERS, WILLIAM NORRIS (contact)

PROJECT_TERMS: Age;Amino Acids;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;antioxidant enzyme;Bacteremia;Bacterial Infections;Bacterial Physiology;Beavers;Biology;cell killing;Cell Survival;Cells;Cessation of life;Chemistry;Coculture Techniques;community setting;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Development;Diagnosis;Disease;Environment;Enzymes;Exhibits;Foundations;Future;Genetic Diseases;Genus staphylococcus;Human;Hydrogen Peroxide;Immune system;improved;Infection;Infectious Skin Diseases;Inflammation;Lactams;Life Expectancy;Lung;Lung infections;lung injury;methicillin resistant Staphylococcus aureus;Methionine;methionine sulfoxide;methionine sulfoxide reductase;Minor;mortality;Mucous body substance;Mus;neutrophil;Neutrophil Infiltration;Nosocomial Infections;novel therapeutics;Organism;Outcome;Oxidants;oxidation;oxidative damage;Oxidative Stress;Oxidoreductase;pathogen;Pathogenesis;Pathway interactions;Patients;Peroxidases;Physiology;Pneumonia;Population;Predisposition;Prevalence;prevent;Process;Production;protein profiling;Proteins;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;repaired;Resistance;resistant strain;Respiratory Burst;response;Role;Savings;Sepsis;small molecule;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Substrate Specificity;Sulfhydryl Compounds;Superoxides;System;Testing;Therapeutic;United States;Virulence;Virulence Factors

PROJECT_TITLE: Methionine sulfoxide reductases and Staphylococcus aureus pathogenesis in the cystic fibrosis lung


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: CHEN, CHEN  (contact)

PROJECT_TERMS: Adhesions;Affect;Antibiotic Resistance;Antigen-Antibody Complex;Asthma;Bacterial Toxins;Binding;Binding Sites;Biology;Blocking Antibodies;Bronchoalveolar Lavage Fluid;Cell Adhesion;Cell Adhesion Molecules;Cell Line;Cell model;cell motility;Cell surface;Cellular biology;Centers of Research Excellence;clinical risk;Clustered Regularly Interspaced Short Palindromic Repeats;CSF3 gene;cytokine;Data;Death Rate;Dedications;defined contribution;design;Disease;Environment;Equilibrium;Etiology;Family member;Fostering;Genus staphylococcus;glycosylation;Goals;high risk;HL-60 Cells;host colonization;Host Defense;Human;Immune Evasion;Immune system;immunopathology;in vitro activity;in vivo;Individual;Infection;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;Inhalation;inhibiting antibody;insight;Integrins;Intensive Care;Intensive Care Units;Interleukin-6;Invaded;Knock-out;Lipids;Lung;Lung infections;Mediating;migration;Molecular;Molecular Biology;Molecular Conformation;Molecular Disease;Motility;mouse model;Mus;neutrophil;Neutrophil Infiltration;novel therapeutics;Null Lymphocytes;opportunistic pathogen;pandemic influenza;pathogen;Pathogenesis;Pathogenicity;Patients;Phase;Pneumonia;pneumonia model;pneumonia treatment;Polysaccharides;Prevalence;Protein Family;Proteins;Recombinants;Reporting;Rest;sialyl Lewis a;sialyl Lewis x;Signaling Molecule;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;Superantigens;System;Testing;Tissues;Toxin;United States;Vaccines;ventilator-associated pneumonia

PROJECT_TITLE: How S. aureus protein SSL11 inhibits neutrophil migration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Obesity;Pneumonia and Influenza

PI_NAMEs: CAROSSINO, MARIANO  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Adipocytes;Affect;Air;airway epithelium;Alveolar;alveolar epithelium;Automobile Driving;Biological;Biological Models;Biology;cell injury;Cells;Chronic;Clinical;clinically relevant;combat;comorbidity;Complex;Conditioned Culture Media;Coronavirus;Coronavirus Infections;COVID-19;defined contribution;Development;diabetic;Disease;Disease Outcome;Dissection;Elements;Epithelium;evidence base;Exposure to;Future;General Population;Goals;high risk;Human;Immune;Immune response;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Response;Influentials;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;innovation;Intensive Care;Intervention;Knowledge;Leptin;leptin receptor;Leptin resistance;Life;Liquid substance;Lung;Lung Diseases;lung injury;Macrophage;Metabolic;Metabolic Diseases;Modeling;Morbid Obesity;mouse model;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;obese person;Obesity;Outcome;Overweight;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;permissiveness;Persons;Population;Populations at Risk;Predisposition;Prevalence;Public Health;pulmonary function;Receptor Signaling;Research;respiratory;respiratory virus;response;Risk;Role;SARS-CoV-2 infection;severe COVID-19;Shapes;Signal Pathway;Signal Transduction;Small Interfering RNA;STAT3 gene;Structure of parenchyma of lung;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tissue culture;tool;Viral;Viral Respiratory Tract Infection;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: The role of adipocyte-drive inflammation and leptin pathway in pulmonary viral infections caused by SARS-CoV-2 and influenza A viruses


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Pulmonary Fibrosis

PI_NAMEs: ABUAITA, BASEL HANNA (contact)

PROJECT_TERMS: Acute;acute infection;Address;Air Pollutants;Alveolar;alveolar epithelium;Anatomy;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Asthma;Autoimmune Diseases;bactericide;biological adaptation to stress;Biology;cancer cell;catalase;Cell Physiology;Cells;Cellular Stress;cellular targeting;Chronic;Chronic Disease;chronic inflammatory disease;cytokine;Data;design;Development;Dinoprostone;Disease;Disease Outcome;Disease Progression;disorder control;Drug Metabolic Detoxication;Drug resistance;drug resistant pathogen;Economic Burden;endoplasmic reticulum stress;Ensure;Enzymes;epithelial to mesenchymal transition;experimental study;Exposure to;extracellular;Fostering;Gases;Generations;Genetic;Goals;Health care facility;Host Defense;Human;idiopathic pulmonary fibrosis;Immune;immune cell infiltrate;Immune response;Immune signaling;immunomodulatory strategy;immunoregulation;Immunotherapy;in vivo;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;Inhalation;inhibitor;innate immune function;innovation;Inositol;insight;Interleukin-1 beta;Interleukin-6;interstitial;Investigation;Kinetics;KRAS2 gene;Link;Lipids;lipoxin A4;Lung;lung development;Lung Diseases;Lung infections;Macrophage;Mediating;methicillin resistant Staphylococcus aureus;microbial;Mitochondria;Modeling;Monitor;Morbidity - disease rate;multi-drug resistant pathogen;Mus;Myelogenous;neutrophil;new therapeutic target;Nosocomial Infections;Organ;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Phagocytosis;pharmacologic;Pneumonia;Positioning Attribute;Production;Protein Deficiency;Publishing;Pulmonary Fibrosis;Pulmonary Pathology;Reactive Oxygen Species;Regulation;Resolution;Respiratory Disease;response;Role;sensor;Sepsis;Signal Pathway;Signal Transduction;Site;Skin;skin abscess;Staphylococcus aureus infection;Stress;subcutaneous;System;Testing;Therapeutic;Tissues;TNF gene;Toxic Environmental Substances;Transgenic Mice;TXNIP gene;United States;United States National Institutes of Health;Vancomycin Resistance;Work

PROJECT_TITLE: Regulation of Pulmonary Host Defenses by the Endoplasmic Reticulum Stress Sensor IRE1α


NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Microbiome;Nutrition;Sleep Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative  The population of older individuals is increasing at a faster pace than all other age groups. Nevertheless, the quality of life and ‘healthy aging’ (i.e., freedom from chronic diseases and good functioning at individual and group levels) may be as, if not more important, than the number of years added to our lifespan, for both individuals and society. This makes it essential to understand the mechanism and identify factors contributing towards healthy aging. Here we will examine the role of abnormal time of eating (a common lifestyle factor that affects circadian rhythm) in accelerating aging by modulating intestinal barrier damage, microbiota dysbiosis, gut leakiness and pancreas damage. Microbial signaling networks and their interaction with host biological rhythms as targetable mechanisms involved in aging will be studied. Findings from these experiments will identify intervenable mechanisms to prevent organ damage by age.

PI_NAMEs: BISHEHSARI, FARAZ  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Address;Affect;Age;age acceleration;age group;age-related disease;Aging;aging mechanism;aging population;aging process;aging related;aging related disease;Animals;anti aging;Bacterial Translocation;Biological;Biological Rhythm;carcinogenesis;Chronic;Chronic Disease;circadian;Circadian Dysregulation;Circadian Rhythms;cohort;Collection;Cues;Data;Deposition;Diabetes Mellitus;Diet;dysbiosis;Eating;Elderly;epidemiology study;Epithelium;Etiology;experience;experimental study;Exposure to;Fatty acid glycerol esters;Food;Freedom;Functional disorder;Future;Genetic;gut inflammation;gut microbiome;gut microbiota;healthy aging;Homeostasis;host microbiome;Human;Impairment;Individual;Infiltration;Inflammaging;Inflammation;Injury;insight;Insulin Resistance;insulin secretion;Intervention;intestinal barrier;intestinal injury;Intestines;Knowledge;Leaky Gut;life span;Life Style;lifestyle factors;Link;Malignant Neoplasms;Mediating;Microbe;microbial;microbiome;microbiota;Modernization;multiorgan injury;Mus;novel;Older Population;Organ;organ injury;Organoids;Pancreas;Pancreatic Injury;Pathology;Pathway interactions;Peripheral;Phenotype;Physiology;prevent;prophylactic;Proxy;Quality of life;resilience;resilience in aging;response;Risk;Role;Signal Transduction;Societies;Surface;System;systemic inflammatory response;Time;Work

PROJECT_TITLE: Impact of Circadian-Microbiome Interaction on the Gut-Pancreas Axis in Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology

ORG_CITY: Aurora

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE We are requesting funds to purchase an Zeiss LSM 980 2p ready microscope system, to replace a -10 year old heavily used microscope system within the Advanced Light Microcopy core at the University of Colorado Anschutz medical campus. This system will enable the continued use of vital microscopy capabilities that are required by >140 NIH-funded investigators, which is represented by the innovative research performed by major and minor users. The ALMC is well placed to maximize the use of this system based on our extensive experience working with advanced microscope systems, highly skilled staff, knowledgeable faculty and strong institutional support.

PI_NAMEs: BENNINGER, RICHARD KP (contact)

PROJECT_TERMS: Aging;Budgets;Colorado;Confocal Microscopy;Contract Services;Coupling;detection sensitivity;detector;Discipline;Doctor of Philosophy;fluorescence lifetime imaging;Funding;imaging system;Institution;instrument;Lasers;light microscopy;Manufacturer;Measurement;Medical;medical schools;Microscope;Microscopy;Minor;multi-photon;neurotechnology;Performance;Photons;Principal Investigator;Research;Resolution;Sampling;Sapphire;Shapes;Speed;System;Technology;Testing;two photon microscopy;two-photon;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Inverted multi-photon confocal microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Orphan Drug;Pain Research;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: CLEVELAND

ORG_NAME: BIOCHIP LABS, INC.

ORG_STATE: OH

PHR: PROJECT NARRATIVE The goal of this project is to establish the manufacturability, analytical validation, and clinical utility of the OcclusionChip in providing comprehensive functional characterization of red cell biorheological properties and assessment of patient-specific response to emerging targeted and curative therapies in sickle cell disease. With this Administrative Supplements to Promote Diversity, our goal is to provide a mentorship, advising, and a unique research experience to Ms. Madeleine Tincher. This opportunity will prepare her for a future career as a successful translational researcher and entrepreneur.

PI_NAMEs: FEDERICI, CHIARA  (contact);GURKAN, UMUT A.

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: acute chest syndrome;Address;Adhesiveness;Administrative Supplement;Antisickling Agents;autosome;Biological Assay;Blood capillaries;Blood Vessels;Businesses;capillary bed;career;Cell Adhesion;Clinical;clinical efficacy;commercialization;comorbidity;companion diagnostics;Contracts;conventional therapy;curative treatments;design;Devices;diagnostic assay;Disease;Engineering;Erythrocytes;experience;Future;gene therapy;Goals;Healthcare;Hematological Disease;Hemoglobin;improved;In Vitro;indexing;Inherited;manufacturability;manufacture;Manufacturer;manufacturing process;Measures;Mediating;Medical Technology;Mentorship;microfluidic technology;Microfluidics;Morbidity - disease rate;Morphology;mortality;novel;Organ failure;Pain;Pathologic;patient response;Perfusion;Pharmaceutical Preparations;Phase;Physiologic arteriovenous anastomosis;Play;Population;Property;Quality Control;Research;research and development;Role;Scientist;Sickle Cell Anemia;Side;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Standardization;Stroke;targeted treatment;Translating;translational scientist;Treatment Efficacy;underserved community;Validation

PROJECT_TITLE: Microfluidic Technology for Concurrent Assessment of Red Blood Cell Adhesion and Deformability (Administrative Supplement)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Lung;Pediatric

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Over 200,000 children have a 911 Emergency Medical Services (EMS) activation for respiratory distress each year, most of whom have acute wheezing. Early treatment in the prehospital setting could more rapidly relieve respiratory distress symptoms, prevent hypoxia, reduce invasive interventions, and reduce the need to be hospitalized, thereby facilitating earlier return to normal daily activities. This proposal is for a pilot trial that implements ipratropium and dexamethasone into a prehospital treatment bundle for children with acute wheezing.

PI_NAMEs: HANSEN, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 2 year old;911 call;acceptability and feasibility;Accident and Emergency department;Acute;Address;Admission activity;Adrenal Cortex Hormones;Advisory Committees;aged;Albuterol;Applied Research;Area;Asthma;care systems;Child;Child health care;Childhood Asthma;Clinical;Clinical Trials;Community Hospitals;Data;design;Dexamethasone;Diagnosis;Early treatment;Effectiveness;Emergency Care;Emergency medical service;Emergency Situation;Ensure;Environment;evidence base;Feasibility Studies;Feedback;Goals;Health;hospital admission rate;Hospitalization;Hospitals;Hybrids;Hypoxia;implementation evaluation;implementation intervention;improved;Inhalation;innovation;interest;Intervention;Intravenous;Ipratropium;Methods;Methylprednisolone;metropolitan;Modeling;Needles;neglect;Oral;Oral Administration;Outcome;Outcome Measure;Paramedical Personnel;participant enrollment;Patient-Focused Outcomes;Patients;pediatric emergency;Pediatric Research;Pharmaceutical Preparations;Phenotype;Pilot Projects;pilot trial;Pre-hospital setting;Pre-hospitalization care;prevent;Protocols documentation;Provider;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Research;Research Infrastructure;Resources;respiratory;Respiratory distress;Respiratory Signs and Symptoms;Safety;service organization;service providers;Signs and Symptoms;Site;standard of care;Structure;study population;Surveys;Symptoms;System;Time;Training;Treatment Protocols;treatment risk;treatment services;United States National Institutes of Health;Wheezing

PROJECT_TITLE: Treating Respiratory Emergencies in Children (T-RECS) Feasibility Study

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: FARMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative We will conduct a double-blind randomized crossover efficacy trial of in-home air filtration for near highway homes lacking mechanical air handling systems. Our main health endpoints will be hsCRP and peripheral blood pressure. Air monitoring in a subset of homes will include particle number count (ultrafine particles) and PM2.5.

PI_NAMEs: BRUGGE, DOUG  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acceleration;Adult;Affect;Air;air filter;air filtration;air monitoring;Air Pollution;Airborne Particulate Matter;Animals;Area;arterial stiffness;Atherosclerosis;Biological;Biological Markers;Blinded;Blood Pressure;blood pressure reduction;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Chemicals;Chronic;Cities;Clinical;Coagulation Process;community based participatory research;community intervention;comparison intervention;Country;Cross-Over Trials;Data;design;Diastolic blood pressure;Double-Blind Method;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;efficacy trial;endothelial dysfunction;Enrollment;Epidemiology;Evaluation;exhaust;experience;Exposure to;Fibrin fragment D;Filtration;fine particles;Future;Goals;Health;Health Benefit;high efficiency particulate air filter;Home;Hour;Household;Human;improved;indoor air;Inflammation;inflammatory marker;innovation;Intention;Intervention;Intervention Studies;Intervention Trial;Literature;Los Angeles;Low income;Marketing;Measures;Mechanical ventilation;Mechanics;metabolome;Morbidity - disease rate;mortality;Motor Vehicles;Myocardial Infarction;Observational Study;Outcome;Participant;particle;Particulate;Particulate Matter;Pathway interactions;peripheral blood;Pilot Projects;Plasma;Policies;pollutant;Pollution;pressure;Pulse Pressure;Randomized;Research;Research Design;research study;respiratory;response;Risk;Risk Reduction;Schools;Series;Social Sciences;Source;Surveys;System;Systolic Pressure;Testing;Toxicology;traffic-related air pollution;ultrafine particle;urban area;Work

PROJECT_TITLE: HAFTRAP-Home Air Filtration for Traffic-Related Air Pollution

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: PROJECT NARRATIVE The Wadsworth Center’s Human Health Exposure Analysis Resource (WC-HHEAR) will capitalize on Wadsworth’s strengths and extensive capabilities as a world class public health laboratory and research institute by providing NIH-funded researchers with access to state-of-the-art analytical facilities. Collaborations with NIH- funded researchers via HHEAR will leverage access to Wadsworth’s analytical expertise to provide high quality, accurate, measurements for a broad range of environmental contaminants in human biospecimens with the broader goal of advancing knowledge of environmental health issues at all life stages.

PI_NAMEs: KANNAN, KURUNTHACHALAM ;PARSONS, PATRICK J. (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Adipose tissue;Amniotic Fluid;Biological;Biological Assay;Biological Markers;Biological Monitoring;Blood;bone;Chemicals;Client;Collaborations;Collection;Communication;Consult;Consultations;cost;Coupled;Data;data exchange;data harmonization;data quality;Data Reporting;detection limit;Development;Dryness;Ensure;Environmental Exposure;Environmental Health;Environmental Pollutants;environmental stressor;epidemiology study;experience;Follicular Fluid;Funding;Goals;Guidelines;Hair;Health;Heart;high standard;Human;Human Milk;human old age (65+);improved;Individual;Infrastructure;instrumentation;interest;International;Knowledge;Laboratories;laboratory experience;Laboratory Study;Leadership;Life;Liquid substance;Measurement;Measures;Meconium;Methodology;Methods;Mission;Nail plate;novel;novel strategies;operation;Paper;Periodicals;Phase;Placenta;pollutant;population survey;Procedures;Production;programs;prospective;Provider;Public Health;Publications;Publishing;Recommendation;Research Design;Research Institute;Research Personnel;Research Project Grants;Resource Development;Resources;Sampling;Schedule;Seminal Plasma;Shipping;Specimen;Spottings;success;symposium;Techniques;Testing;Tissues;Tooth structure;Trace Elements;Umbilical cord structure;United States National Institutes of Health;Work

PROJECT_TITLE: Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)


PI_NAMEs: PARSONS, PATRICK J. (contact)

PROJECT_TERMS: Agreement;analytical method;assay development;Benchmarking;Biological Monitoring;Child Health;Child Support;Client;Collaborations;collaborative environment;Communication;computerized data processing;Data;data centers;data exchange;Data Files;data management;data quality;Data Reporting;Development;digital media;Documentation;Ensure;Environmental Exposure;Environmental Health;Evaluation;Funding;Goals;Grant;Health;Human;Human Resources;improved;Institution;Institutional Review Boards;Joints;Laboratories;Leadership;meetings;New York;operation;organizational structure;outreach;Personnel Management;Policies;Positioning Attribute;Procedures;Productivity;Progress Reports;Protocols documentation;Quality Control;Recommendation;recruit;Reporting;Research;Research Personnel;Resources;Route;sample collection;Sampling;Schedule;Self Assessment;Services;Shipping;Specimen;success;Surveys;symposium;System;Teleconferences;Test Result;Trace Elements;Training;Travel;United States National Institutes of Health;Update;Vertebral column;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE. The experiments in this proposal will examine the functions of memory B cells that live in the lung and respond to influenza infection and compare them with memory B cells that live at systemic sites. We will also determine how various vaccination strategies enhance or impair the formation of memory B cells in the lung, experiments that are critically important for understanding how and when vaccines should be administered in the respiratory tract.

PI_NAMEs: RANDALL, TROY D (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Affinity;Anti-Inflammatory Agents;Antibodies;Antibody Formation;Antigens;Antiinflammatory Effect;antiviral immunity;B Cell Proliferation;B-Lymphocytes;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;combat;cytokine;Effector Cell;experimental study;flu;Future;Generations;Helper-Inducer T-Lymphocyte;Immunoglobulin Class Switching;Impairment;Individual;Infection;Infection prevention;Inflammation;Inflammatory;Influenza;influenza infection;influenza virus strain;Interleukin-10;Interleukin-6;Ligands;Longevity;Lung;lymphoid organ;Lymphoid Tissue;Maintenance;Mediating;Memory B-Lymphocyte;mutant;neutralizing antibody;novel;pathogen;Peripheral;Phenotype;Population;Proliferating;Property;protective effect;Proteins;Pulmonary Inflammation;pulmonary vaccination;Reaction;repaired;Respiratory System;response;self-renewal;Site;Specificity;stem cell population;T-Lymphocyte;Tissues;TNFSF4 gene;TNFSF5 gene;Tumor Necrosis Factor-Beta;Vaccinated;vaccination strategy;Vaccines;Virus;Work

PROJECT_TITLE: Protective functions of influenza-specific lung-resident memory B cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Some adolescents are especially susceptible to peer influence, which predicts their engagement in substance use. The study of neural networks, and how connectivity within and between these neural networks changes over adolescence, will offer important insights into why some adolescents are especially susceptible to peers and most at risk for substance use onset.

PI_NAMEs: LINDQUIST, KRISTEN ANN;TELZER, EVA HAIMO (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;adolescent substance use;Affective;affective neuroscience;Age;Alcohols;Awareness;Behavior;Biological;Brain;cohort;Complex;critical developmental period;Data;Development;Drug usage;early adolescence;Environment;executive function;Exposure to;Feeling;Friends;Functional Imaging;Funding;Health;high school;Individual;Individual Differences;innovation;insight;Intervention;life span;longitudinal design;maladaptive behavior;Marijuana;Measures;mentalization;Morbidity - disease rate;mortality;Motivation;neural;neural correlate;neural network;Neurobiology;neuroimaging;Neurosciences;Opioid;Patient Self-Report;peer;peer influence;Perception;Performance;Predisposition;pressure;Prevention;Process;prospective;protective factors;psychologic;Psychopathology;Punishment;Reporting;Research;resilience;Rewards;Risk;Risk Behaviors;Sampling;social;Social Environment;social influence;Social Psychology;Socialization;Substance abuse problem;Substance Addiction;substance use;successful intervention;System;Theoretical model;Thinking;Time;Tobacco;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Neurobiological susceptibility to peer influence and drug use in adolescence

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Genetics;Human Genome;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE We test fundamental ideas about how the circadian clock modulates skin regeneration and aging and how these processes are affected by time of feeding. Skin aging causes skin fragility and delayed wound healing, a common cause of chronic wounds in the elderly, which poses a major public health problem in the aging population. This work may lead to new ideas about how to maintain skin strength and regenerative ability into old age.

PI_NAMEs: ANDERSEN, BOGI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Abbreviations;Acceleration;adult stem cell;Affect;Age;age related;Aging;aging population;Animals;ARNTL gene;Binding;Cell Cycle;Cell Cycle Progression;Cell Cycle Stage;cell injury;Cell Respiration;Cells;Chromatin;chronic wound;Chronology;Circadian desynchrony;circadian pacemaker;Complement;Data;Dietary Intervention;Diurnal Rhythm;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA Sequence Alteration;DNA sequencing;Eating;Elderly;Environment;epidermal stem cell;Epidermis;epithelial stem cell;Epithelium;Excision Repair;Exhibits;feeding;feeding schedule;fluorescence lifetime imaging;Frequencies;Functional disorder;Funding;Gene Expression;Genes;Genomic approach;Grant;Growth;Hair;Health;Homeostasis;human old age (65+);Impaired wound healing;in vivo;innovation;insight;Interferons;Intrinsic factor;keratinocyte;life span;Liver;Mediating;Metabolic;metabolic imaging;Metabolism;Modeling;Mus;Mutate;Mutation;Organ;Oxidation-Reduction;oxidative DNA damage;Oxidative Phosphorylation;Peripheral;Phase;Process;Public Health;Reactive Oxygen Species;regeneration function;regenerative;Regulation;response;Role;S phase;single-cell RNA sequencing;Skin;Skin Aging;skin regeneration;stem cell aging;stem cell function;stem cell proliferation;stem cells;Sun Exposure;suprachiasmatic nucleus;System;Testing;Time;Time-restricted feeding;Tissues;transcriptome;UVB induced;Work;Xeroderma Pigmentosum Complementation Group A;XPA gene

PROJECT_TITLE: Circadian Clock Regulation in Skin

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: OVERALL- Narrative Older adults are disproportionally sensitive to infection and also suffer from elevated levels of cancer and of certain types of autoimmunity. A decline in immune function decisively contributes to this vulnerability, and a decline in T cell function and maintenance is responsible for much of that decline. This Program is designed to continue to significantly contribute to fundamental knowledge of T cell aging, but more importantly to yield one or more combined interventions that improve immune defense against infection in aged mouse models, paving the way for interventions to improve T cell immunity and healthspan in older humans, providing also for substantial health care and overall economy savings and benefits.

PI_NAMEs: NIKOLICH, JANKO Z. (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 2019-nCoV;Address;Affect;Age;age related;age related changes;aged;Aging;animal tissue;Archives;Autoimmune Diseases;Autoimmunity;Bone Marrow;Cell Aging;Cell Count;Cell Maintenance;Cell Physiology;Cell Survival;Cells;central tolerance;Communicable Diseases;Communication;comparative;COVID-19 pandemic;Data Science;data sharing;Defect;design;Deterioration;Dissection;Economic Burden;Economics;effective intervention;Elderly;Elements;Event;experience;Failure;Gene Expression Profiling;Genetic Models;Goals;Health;Healthcare;healthspan;high throughput analysis;Human;Immune;immune function;Immune response;Immune system;immune system function;Immunity;Immunologics;immunosenescence;Impairment;improved;Individual;Infection;Infectious Agent;Informatics;Injury;Intervention;Knowledge;Laboratories;Length;Life;life span;lymph nodes;lymphoid organ;Maintenance;Malignant Neoplasms;Modality;Molecular;Monitor;mortality;mouse model;Mus;Natural regeneration;neoplastic cell;novel;old mice;older adult;Output;Pathway interactions;Peripheral;peripheral lymphoid organ;Phenotype;Pre-Clinical Model;primary lymphoid organ;Process;Production;programs;Quality of life;Reagent;Regenerative capacity;Rejuvenation;Research;response;Role;Sampling;Savings;Science;secondary lymphoid organ;Self Tolerance;Signal Transduction;Societies;Spleen;Standardization;Statistical Data Interpretation;success;synergism;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;timeline;Translating;Translations;Virus

PROJECT_TITLE: Thymic and Peripheral Aspects of T Cell Aging and Rejuvenation


NIH_SPENDING_CATS: Aging

PROJECT_TITLE: Scientific Integration and Administration


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LAFLEUR, BONNIE  (contact)

PROJECT_TERMS: Address;Aging;Algorithms;Benchmarking;Bioconductor;Bioinformatics;Biological;Biometry;Categories;Cell Aging;Cells;Code;Collaborations;Computational Biology;cyber infrastructure;Data;Data Analyses;data and analysis portal;data harmonization;data integration;data management;Data Provenance;data quality;data repository;Data Science Core;Data Set;design;Development;differential expression;Documentation;Ensure;Environment;experimental analysis;Experimental Designs;experimental study;Flow Cytometry;Formulation;Fostering;Goals;high throughput technology;Human;Immune;Immune response;improved;In Vitro;Infrastructure;Knowledge Management;Maps;Measures;Metadata;method development;Methodology;Methods;Modernization;multimodality;Mus;novel;Pathway Analysis;Performance;Peripheral;programs;Rejuvenation;repository;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Role;Sample Size;Scientist;single cell analysis;single-cell RNA sequencing;sound;Specialist;Standardization;Statistical Computing;Statistical Methods;statistics;Structure;T-Lymphocyte;Technology;Testing;Thymus Gland;tool;Update;Viral;web based interface;Work

PROJECT_TITLE: Data Sciences Core


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: HALE, LAURA P. (contact)

PROJECT_TERMS: Acceleration;Age;age associated immune deficiency;age related;age related changes;aged;Aging;Architecture;biobank;Biological Assay;Biology;Board Certification;Cell Aging;Cell Line;Cell Separation;Collection;Consultations;Cryopreservation;Cryopreserved Tissue;Cryoultramicrotomy;Custom;Data;Data Science Core;Defect;Development;Dimethyl Sulfoxide;Ensure;Flow Cytometry;Formalin;Foundations;Freezing;Gene Expression;Gene Expression Profiling;Goals;Histologic;Histology;Human;human tissue;Image;Immune;improved;Individual;Infection;innovation;Leadership;life span;lymph nodes;Maintenance;Malignant Neoplasms;Methodology;Methods;Modernization;Molecular;Molecular Analysis;Monitor;morphometry;mouse model;Mus;older adult;Output;Paraffin Embedding;Pathology;Pathway interactions;Peripheral;preservation;Production;programs;Quality Control;Rejuvenation;Research Project Grants;RNA analysis;Sampling;secondary lymphoid organ;Services;sex;single-cell RNA sequencing;Specific qualifier value;Specimen;Stromal Cells;synergism;T-Lymphocyte;therapeutic target;Thymic epithelial cell;Thymic Tissue;thymocyte;Thymus Gland;Tissue Donors;Tissue Embedding;Tissues;Translations;Vaccines;Work

PROJECT_TITLE: Human Target Verification and Thymic Function Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative The University of North Carolina at Chapel Hill Intensive Summer Research Training in Emergency Medicine (ISTEM) program will allow eight medical students per year to experience public health and medical research first-hand in topics related to emergency medicine and patient care of the heart, lungs, and blood. This program will provide the opportunity to gain relevant experience and insight into the research field directly under well-published, grant-funded mentors while maintaining strict guidelines and expectations. The value of this program will be immeasurable as ISTEM will influence the future direction of upcoming physician researchers early in their academic career.

PI_NAMEs: BRICE, JANE ;MEYER, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Administrator;Advisory Committees;American Heart Association;Area;Blood;Blood Coagulation Disorders;cardiovascular health;career;Clinical Research;Competence;Development;Education;Emergency Medicine;Environment;Epidemiology;experience;Exposure to;Female;Foundations;Funding;Goals;Health Services;Heart;Hematological Disease;improved;interest;Journals;Lung;lung health;Manuscripts;Medical Students;meetings;Mentors;Methods;National Heart, Lung, and Blood Institute;North Carolina;Outcome;Peer Review;Physicians;Positioning Attribute;posters;Process;Productivity;Program Evaluation;programs;Publications;Publishing;recruit;Reproducibility;Research;Research Design;Research Ethics;Research Institute;Research Project Grants;Research Training;Scientist;Self Efficacy;Self Perception;Students;success;summer research;Training;training opportunity;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Writing


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

PI_NAMEs: UHRLAUB, JENNIFER L. (contact)

PROJECT_TERMS: adaptive immunity;Age;Aging;animal resource;Animals;Antibodies;Application procedure;Arizona;arm;B-Lymphocytes;Biological Assay;Biological Models;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cell Maintenance;Cell Physiology;Cellularity;Central Nervous System;central tolerance;Combined Modality Therapy;Communicable Diseases;Competence;Cost Savings;Data;Data Analyses;Data Collection;Dedications;efficacy evaluation;Elderly;Emigrant;Ensure;Failure;Female;functional improvement;Generations;Goals;Human;Human Resources;Immune;immune function;Immune response;Immune system;Immunity;Immunology procedure;improved;in vivo evaluation;Intervention;Knowledge;Laboratories;Listeria monocytogenes;lymph nodes;Maintenance;male;Measures;Mediating;member;Modeling;Monitor;Morbidity - disease rate;mortality;Mus;old mice;older adult;Other Genetics;Output;Ovalbumin;Ovum;pathogen;Peripheral;Point Mutation;pre-clinical;Predisposition;Procedures;Production;programs;Protocols documentation;Quality Control;Reagent;Rejuvenation;Reporting;Research;Resolution;response;sample collection;secondary lymphoid organ;Services;Specimen Handling;Spleen;T cell reconstitution;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Thymus Gland;Training;Translating;Translations;Universities;Vaccines;Variant;Virus Diseases;West Nile viral infection;West Nile virus

PROJECT_TITLE: Human Translation and Verification


NIH_SPENDING_CATS: Aging;Regenerative Medicine

PI_NAMEs: DUDAKOV, JARROD  (contact)

PROJECT_TERMS: Accounting;Acute;Adrenal Cortex Hormones;Age;age related;age related changes;age related decline;aged;Aging;Antigens;Apoptosis;BMP4;cancer therapy;Cell Aging;Cell Compartmentation;Cell Death;Cell Physiology;Cells;chemotherapy;Chronic;Clinical;Collaborations;Complex;conditioning;Data;Data Set;Defect;Detection;Effectiveness;Endothelial Cells;Epithelium;Equilibrium;G-Protein-Coupled Receptors;Generations;Goals;GPR39 gene;Hematopoietic;Hematopoietic Stem Cell Transplantation;Immune;immune function;Immunity;immunogenic cell death;improved;Infection;Inflammatory;Injury;interleukin-22;interleukin-23;Intervention;Ionizing radiation;juvenile animal;life span;Lymphoid Cell;Lymphopenia;Malignant - descriptor;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;notch protein;novel;old mice;older patient;Pathway interactions;Patients;Pattern;Peripheral;Population Heterogeneity;preclinical study;Production;programs;Puberty;Purinergic P2 Receptors;Radiation therapy;regenerative;Regenerative capacity;Regenerative response;regenerative therapy;Regulation;Rejuvenation;Relapse;repaired;reparative capacity;response;Role;sex;Sex Differences;Shock;Signal Transduction;single cell sequencing;Stimulus;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thymic epithelial cell;thymic regeneration;Thymus Gland;Tissues;Transplantation;Work;Zinc

PROJECT_TITLE: Response of aged thymus to injury and rejuvenation signals


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: EHRLICH, LAUREN ILYSE RICHIE (contact)

PROJECT_TERMS: Adult;Age;age related;age related changes;age related decline;Aging;Antigen-Presenting Cells;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Avidity;Biological Assay;Bone Marrow;Cell Aging;Cell Compartmentation;Cell Physiology;Cells;Cellularity;central tolerance;Data;Data Set;Defect;Development;fetal;Frequencies;functional restoration;Gene Expression Profiling;Generations;Genetic;Goals;Health;Hematopoiesis;Hematopoietic;Human;Image;imaging approach;immune function;Immune response;Immunity;Impairment;improved;Incidence;life span;Ligands;Lymphoid;Lymphopoiesis;Maintenance;Malignant Neoplasms;Mediator;middle age;Molecular;Morbidity - disease rate;mouse model;Mus;notch protein;Output;pathogen;Peripheral;Predisposition;prevent;Process;Production;progenitor;programs;Regulatory T-Lymphocyte;Rejuvenation;response;Role;Sex Bias;Signal Transduction;Slice;stem cell differentiation;stem cell niche;stem cells;Stromal Cells;Structure;T cell response;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;thymocyte;Thymus Gland;Tumor Antigens;two-photon;vaccine immunogenicity;Vaccines

PROJECT_TITLE: Role of the microenvironment in regulating early stages of thymic involution and central tolerance


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE To dissect the functional roles of distinct neuron-types in animal perception and behavior, targeted recording techniques that operate at the physiologically relevant spatiotemporal scales should complement current approaches of functional manipulation. Here, we propose to use our new suite of genetically encoded fluorescent voltage indicators for concurrent, high-speed, multipopulation recordings to understand the role of distinct visual cortical interneuron-types in attentional modulation of sensory processing during visually guided behavior. Our proposed work will enable real-time comparisons of the voltage dynamics among and between distinct interneuronal ensembles that contribute to visual gain modulation and establish multipopulation voltage imaging as the preferred method to reveal these interactions at cellular-resolution and millisecond timescales.

PI_NAMEs: KANNAN, MADHUVANTHI  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Voltage dynamics of distinct cortical ensembles in visually guided behavior


PROJECT_TERMS: Adoptive Transfer;Affect;Age;age related;age related changes;aged;Aging;aging related;Atrophic;Blood;BMP4;C57BL/6 Mouse;candidate identification;capsule;catalase;CCL19 gene;CCL21 gene;Cell Aging;Cell Maintenance;cell type;Cells;Cellular biology;Cellularity;Chronology;Coculture Techniques;Collaborations;Complex;Cyclin D1;Dasatinib;Data;Defect;Deterioration;draining lymph node;Endothelial Cells;Exhibits;Exposure to;Family;Family member;fisetin;functional improvement;GDF8 gene;Genetic;GPR39 gene;Homeostasis;Human;IL7 gene;Image;Immigration;Immune;immune function;Immunity;immunosenescence;Impairment;implantation;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Informatics;Interleukin-13;Intervention;keratin 5;Kidney;Lead;Life;lymph nodes;Lymphatic;Lymphoid Cell;lymphoid organ;Maintenance;Messenger RNA;Mitochondria;Molecular;Molecular Target;mouse model;Mus;Natural regeneration;Neonatal;older adult;Operative Surgical Procedures;Organism;Oxidative Stress;Pathway interactions;Peripheral;Population;pre-clinical;Production;programs;promoter;Proteins;Quercetin;Rejuvenation;response;Reticular Cell;Role;secondary lymphoid organ;Secondary to;senescent cell;senolytics;Signal Transduction;single-cell RNA sequencing;Skin;Stromal Cells;Structure;Supplementation;T-Lymphocyte;Testing;Thymus Gland;Time;TNF gene;Transforming Growth Factor beta;Transgenic Mice;Tumor Necrosis Factor Receptor;Work

PROJECT_TITLE: Peripheral T cell maintenance defects with aging


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Homologous recombination is a DNA repair pathway, which plays crucial roles in genetic disorders, cancer and aging, thus, inhibitors of homologous recombination are expected to be more lethal to rapidly growing cancers than to more slowly growing healthy cells. As a first step towards developing targeted therapies that can be used to modulate homologous recombination it is essential to understand the basic biochemical properties of the proteins involved and more fully define their impact on DNA metabolism. To help extend our understanding homologous recombination we have developed a powerful new experimental platform based on state–of–the–art optical microscopy that allows us to address questions in biomedical research that cannot be tackled with more traditional experimental approaches.

PI_NAMEs: GREENE, ERIC C (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Affect;Aging;BARD1 gene;Biochemical;Biomedical Research;BRCA1 gene;Cancer Biology;cancer cell;cancer therapy;Cells;Chromosomal Rearrangement;Chromosomes;Clinical;cofactor;Complex;Defect;Dependence;design;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;DNA metabolism;DNA Repair Pathway;DNA replication fork;DNA strand break;Eukaryota;Eukaryotic Cell;Exhibits;Funding;Future;Genetic Diseases;genetic information;Genetic Recombination;genetic regulatory protein;genome integrity;Genome Stability;Goals;Health;helicase;Homologous Gene;homologous recombination;Human;Human Biology;human disease;Human Genome;Hydrolysis;Individual;inhibitor;insight;Link;Malignant Neoplasms;Mediating;Microscopy;Molecular;Molecular Motors;Mutation;new technology;nucleic acid metabolism;Nucleic Acids;Nucleoproteins;nucleoside triphosphate;Optics;Outcome;p53-binding protein 1;paralogous gene;Pathway interactions;Patients;Play;Predisposition;Premature aging syndrome;presynaptic;prevent;Process;Property;protein complex;Proteins;RAD52 gene;Reaction;recombinase;Recovery;RECQL5 gene;Regulation;repaired;Research;Role;Saccharomyces cerevisiae;single molecule;Single-Stranded DNA;Source;Specificity;Syndrome;targeted treatment;Testing;therapeutic development;time use;tool;Visualization;Work

PROJECT_TITLE: Helicase regulation during homologous recombination

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Disturbance of the normal rhythm of the heart is a common ailment, especially among the elderly, and these life-threatening cardiac arrhythmias are treated by antiarrhythmic drugs. In this project, we will determine the structure of the cardiac sodium and calcium channels, which initiate the heartbeat, analyze the structures of their different functional states, image antiarrhythmic drugs in their sites of action on sodium and calcium channels, and elucidate the structural changes caused by mutations in these ion channels that induce life-threatening arrhythmias. Our results will help to understand the normal function of sodium and calcium channels, their dysfunction in arrhythmias, and the ability of antiarrhythmic drugs to terminate and prevent cardiac arrhythmias, with important implications for discovery of next-generation antiarrhythmic drugs with greater safety and efficacy.

PI_NAMEs: ZHENG, NING  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Affinity;antagonist;Anti-Arrhythmia Agents;Arrhythmia;Binding;Brugada syndrome;Calcium;Calcium Channel;Cardiac;Cardiac Myocytes;Cells;Clinical;Complex;Coupling;crosslink;Cryoelectron Microscopy;Cytosol;Dependence;design;Dihydropyridines;Dilated Cardiomyopathy;Disulfides;drug action;Drug Receptors;Drug usage;Elderly;Functional disorder;heart rhythm;Image;improved;Inherited;insight;Ion Channel;Ions;Learning;Length;Life;Lipid Bilayers;Lipids;Long QT Syndrome;Maps;Membrane Potentials;Methods;Modeling;Molecular;Molecular Conformation;Molecular Target;Mutation;next generation;Pathogenicity;Pharmaceutical Preparations;phenylalkylamine;prevent;Prevention;receptor;reconstitution;Resolution;Rest;Role;Safety;sensor;Side;Site;Sodium;Sodium Channel;Specificity;Structure;Surface;Timothy syndrome;voltage;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Basis for Antiarrhythmic Drug Action

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project will develop a control system for wearable artificial lung systems aimed at reducing suffering and significantly improving the quality of life for tens of thousands of Americans with end stage lung disease who currently have no other treatment option.

PI_NAMEs: POTKAY, JOSEPH ALLEN (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Affect;Age;Air;Air Movements;Alkalosis;American;Anesthesia procedures;Animal Model;Animal Testing;Animals;artificial lung;awake;Blood;Carbon Dioxide;Cattle;Cessation of life;Chest;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;comorbidity;Compensation;Computer software;design;Development;Devices;Disease;Dysbarism;Dyspnea;Engineering;Etiology;Excision;exhaust;Extracorporeal Circulation;first-in-human;Future;Gases;Goals;healing;Hip region structure;Home;Hour;Human;Hypocapnia;improved;In Vitro;in vivo;Injury;innovation;laptop;Life;Lung;Lung Diseases;lung injury;Lung Transplantation;Mechanical ventilation;Metabolic;Methods;Mind;miniaturize;miniaturized device;Monitor;operation;Patients;Performance;Physical Rehabilitation;Physical therapy;Physiology;Population;portability;Prosthesis;prototype;pulmonary function;Pump;Quality of life;Recording of previous events;Recovery;Rehabilitation therapy;Research;respiratory;Respiratory Failure;Rest;Risk;sensor;sheep model;System;Technology;technology development;Testing;Transplantation;United States National Institutes of Health;Ventilator;Volutrauma;Waiting Lists;Water;wearable device

PROJECT_TITLE: Smart, wearable artificial lung system

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Our laboratory studies the structures and mechanisms of site-specific enzymes that act on DNA and RNA targets, and further employs protein engineering to develop novel protein folds and functions and to challenge our understanding of protein form and function. We will renew and expand our research mission by pursuing three new directions that will expand upon our approaches for such studies. We will answer basic questions surrounding the evolution, recognition mechanisms and engineerability of sequence-specific microbial RNA endonucleases and eukaryotic retrotransposons and will address the unsolved problem of accurately designing highly polar biomolecular interfaces achieve the balance of affinity, specificity and reversibility found in many biomolecular interactions.

PI_NAMEs: STODDARD, BARRY L. (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Biophysical and structural studies of protein and enzyme mechanism, evolution, and engineering

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative Deaf children learning American Sign Language (ASL) perceive both language input and information about the world through the visual modality, so they must learn to divide and allocate their visual attention between people and objects in order to learn new words. In the proposed project we will investigate how the timing of parent input relative to child attention supports word learning, and how deaf children learn to divide and allocate their visual attention to learn new words. Findings from this project will inform parents, teachers, and early intervention specialists working with deaf children by documenting optimal strategies to support word learning.

PI_NAMEs: LIEBERMAN, AMY MICHELLE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adult;Age;American Sign Language;Attention;Auditory;Behavior;Behavioral;Benchmarking;Child;Cues;Data Set;deaf;Development;diagnostic tool;Early Intervention;Evaluation;Event;experience;experimental study;Family;Frequencies;gaze;Goals;Head;Hearing;Individual Differences;innovation;insight;Intervention;joint attention;Label;Language;Language Development;language processing;Learning;Linguistics;literacy;Maps;Modality;Nature;novel;Outcome;parallel processing;Parent-Child Relations;Parents;Pattern;Persons;Play;Population;Process;Risk;Role;Sensory;Sign Language;Signal Transduction;skills;Specialist;Structure;sustained attention;teacher;Technology;Testing;theories;Time;Visual;Visual attention;visual information;visual tracking;Vocabulary;word learning;Work

PROJECT_TITLE: Development of Gaze Control for Integration of Language and Visual Information in Deaf Children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: There is an ever increasing need to develop better tools to facilitate the management of controversial cystic pancreatic lesions detected incidentally by imaging. We propose to use a new analytical technique (DEST) to study circulating extracellular vesicles (EV) in patients with incidentally detected intraductal papillary mucinous neoplasms (IPMN), precancerous lesions of the pancreas. This will allow us to discover the make-up of EV in clinical specimen, facilitate the management of controversial lesions and detect individuals with high likelihood of malignant progression. The ultrasenstive vesicle detection method has the potential to transform early pancreatic cancer research and clinical practice.

PI_NAMEs: WEISSLEDER, MD, PHD, RALPH  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Age;anti-cancer research;Assessment tool;biobank;Biological Markers;biomarker signature;biomarker validation;Blinded;cancer biomarkers;cancer cell;Carcinoma;Clinical;Clinical Management;clinical practice;Clinical Trials;cost;Cyst Fluid;Cystic Neoplasm;Data;Detection;detection limit;detection method;digital;Disease;Dysplasia;Early Diagnosis;Emerging Technologies;Enzyme-Linked Immunosorbent Assay;Evaluation;extracellular vesicles;Frequencies;Future;Goals;Guidelines;High grade dysplasia;high risk;Image;Imaging technology;improved;Incidental Findings;Individual;innovation;Laboratories;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of pancreas;Measurement;Methods;Mucinous Neoplasm;new technology;novel marker;Pancreas;Pancreatic Cyst;Pancreatic cystic neoplasia;pancreatic neoplasm;Pancreatitis;Papillary;Pathway interactions;Patients;Periodicals;peripheral blood;Plasma;point of care;premalignant;prospective;protein biomarkers;Proteins;Recommendation;Resolution;Risk Assessment;Sampling;Screening for cancer;Source;Specimen;Surface;Techniques;Technology;technology validation;Testing;Time;tool;Training;tumor progression;Ultracentrifugation;Validation;Vesicle

PROJECT_TITLE: Ultrasenstive vesicle analysis in precancerous pancreatic neoplasm (IPMN)

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: In all vertebrate embryos, the neural crest gives rise to the sensory, autonomic and enteric nervous system, craniofacial skeleton and melanocytes of the skin. Not only does the neural crest have the capacity to form an amazing number of embryonic cell types, but also neural crest stem cells persist in adult tissue. For example, a population of these cells, called Schwann cell precursors, have been found closely associated with peripheral nerves and are present throughout the body, where they have been shown to differentiate into various derivatives including neurons, glia and pigment cells. Because neural crest cells are involved in a variety of birth defects such as Hirschsprung's disease, cleft palate and various types of cancers, like neuroblastoma, melanoma and pheochromocytoma, the results of this proposal regarding neural crest cell diversification across vertebrates will provide important understanding of the normal development of these cells that can later lead to disease states.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Amaze;Autonomic nervous system;Brain;cancer type;Cartilage;cell type;Cells;Cephalic;Cleft Palate;Congenital Abnormality;Congenital Megacolon;craniofacial;Development;Disease;embryo cell;Enhancers;Enteric Nervous System;Evolution;Ganglia;Genes;Genetic Enhancer Element;Genetic Transcription;Head;Homologous Gene;invention;Jaw;Lampreys;Lead;melanocyte;Melanoma;neural;Neural Crest;Neural Crest Cell;Neuroblastoma;Neuroglia;Neurons;novel;Nucleic Acid Regulatory Sequences;Peripheral;Peripheral Nerves;Pheochromocytoma;Pigments;Play;Population;Predatory Behavior;Reporter;Role;Schwann Cells;Sensory;Skeleton;Skin;stem cells;Testing;Tissues;transcription factor;vertebrate embryos;Vertebrates;Zebrafish

PROJECT_TITLE: Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolution