NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: Project narrative All blood cells arise from a common precursor called the hematopoietic stem cell (HSC) and HSC is able to differentiate into mature blood cells as well as to replenish the pool of HSCs. Clinically, HSCs are key for bone marrow transplantation for treating leukemia and other blood diseases. The overall goal of this project is to extend our understanding of how GSK3 regulates HSC function and improve HSC/bone marrow transplantation.

PI_NAMEs: HUANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Agonist;Alleles;Attenuated;Autophagocytosis;Biochemical;Biological Assay;Blood Cells;Bone Marrow;Bone Marrow Stem Cell Transplantation;Bone Marrow Transplantation;Cell Lineage;Clinical;Data;Daughter;Defect;Disease;Dysmyelopoietic Syndromes;exhaustion;Exhibits;fatty acid oxidation;Genes;Genetic;genetic approach;Glycogen Synthase Kinase 3;Goals;Hematological Disease;Hematology;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell expansion;Hematopoietic Stem Cell Research;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Impairment;improved;in vivo;inhibitor;insight;knock-down;Knock-out;Knowledge;Learning;leukemia;lipid metabolism;Lipids;loss of function;Mitochondria;Molecular;Mus;novel;Organelles;Pathway interactions;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phenotype;Phosphorylation;Play;Population;PPAR delta;preference;Preleukemia;Property;Protein Isoforms;Publishing;reconstitution;Regulation;Reporter;RNA Interference;Role;self-renewal;stem cell division;stem cell function;stem cell homeostasis;stem cells;stemness;System;Testing;Therapeutic;Transgenic Mice;Transplantation;Work

PROJECT_TITLE: The role of GSK3/PPAR-/mitophagy pathway in regulating hematopoia

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Depression;Frontotemporal Dementia (FTD);Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Dementia diagnoses are projected to rise exponentially in the next several decades, with the vast majority of patients developing neuropsychiatric symptoms that are burdensome and difficult to treat. One of the most challenging aspects of identifying the biological substrates contributing to symptoms in dementia is that one dementia syndrome can be caused by different postmortem pathologies. This study will examine associations between anatomic distributions of pathology and neuropsychiatric symptoms in primary progressive aphasia— a language-based dementia caused by multiple pathologies—with the goal of uncovering the putative substrates of neurodegeneration that may enhance diagnostic accuracy, predictions of future decline, and treatment approaches.

PI_NAMEs: KESZYCKI, RACHEL M (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affective Symptoms;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;Anatomy;Anterior;Anxiety;Aphasia;area striata;Atrophic;Autopsy;Behavior;Behavioral;Behavioral Symptoms;Bilateral;Biological;Biological Markers;biomedical referral center;Brain;brain behavior;Brain Pathology;Brain region;Caregivers;cerebral atrophy;Cerebrospinal Fluid;cingulate cortex;Clinical;Cognitive;Control Groups;Data;Dementia;Desire for food;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic criteria;digital;digital pathology;Disease;Disease Progression;Disinhibition;Distress;DNA-Binding Proteins;doctoral student;effective therapy;Environment;Etiology;experience;Family;Frontotemporal Lobar Degenerations;Future;Goals;Human;Impaired cognition;International;Knowledge;Language;Lead;Left;Mental Depression;Methods;Microglia;Microscopic;Moods;Motivation;multidisciplinary;Nerve Degeneration;neural network;Neuroanatomy;Neurobehavioral Manifestations;neurodegenerative dementia;neuroimaging;neuroinflammation;Neurons;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neuropsychology;Onset of illness;Participant;Pathologic;Pathology;Patients;Pattern;Persons;Phenotype;Positron-Emission Tomography;Prefrontal Cortex;Prevalence;Primary Progressive Aphasia;Process;Prognosis;Progressive Aphasias;protein TDP-43;psychiatric symptom;Psychoses;Public Health;Regulation;repetitive behavior;Research;response;Specimen;STEM field;Symptoms;Synapses;Syndrome;Tauopathies;Testing;Time;Training;translational scientist;Work

PROJECT_TITLE: Pathologic Substrates of Neuropsychiatric Symptoms in Aphasic Dementia


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE The dissemination of antibiotic resistance and the drying-up of antibiotic discovery pipelines threaten to increase morbidity from routine medical procedures and worsen the spread of infectious diseases. The proposed research aims to apply physical modeling to develop a fundamental, mechanistic understanding of how known antibiotics kill bacterial cells, and to harness this understanding using machine learning to discover unprecedented classes of antibiotics. This work is relevant to NIH’s public health mission because it will inform the clinical treatment of bacterial infections and offer new platforms for antibiotic discovery.

PI_NAMEs: WONG, FELIX  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;anti-fungal agents;Antibiotic Resistance;Antibiotics;Award;Bacterial Antibiotic Resistance;Bacterial Infections;bactericide;Biological;Biological Process;Biology;Biotechnology;career;Cell Death;Cell Death Induction;cell envelope;Cells;Cellular Structures;Chemical Structure;Chemicals;chemotherapy;Classification;Clinical;Clinical Treatment;clinically relevant;Communicable Diseases;computational platform;Computer Models;Cytoplasm;cytotoxicity;Data;Data Set;deep learning;deep neural network;Development;drug discovery;Drug Kinetics;Drug Targeting;Dryness;Escherichia coli;Experimental Models;experimental study;Fluorescence Microscopy;Fluoroquinolones;Genetic;Goals;graph neural network;Health;Health Care Costs;high throughput screening;Human;in silico;In Vitro;in vivo;Infection;infectious disease treatment;insight;Knock-out;Laboratories;laboratory experiment;Lead;Light;Machine Learning;Mass Spectrum Analysis;mathematical model;Measurement;Mechanics;Medical;Mentorship;Methods;Microfluidics;Microscopy;Mission;Modeling;Modification;Morbidity - disease rate;Multi-Drug Resistance;Mus;novel;novel antibiotic class;novel therapeutics;Optics;overexpression;Oxazolidinones;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;physical model;physical property;Prevention;Procedures;Property;prospective;Public Health;Research;Research Personnel;skills;small molecule libraries;Source;System;Systems Biology;Testing;Training;training data;United States National Institutes of Health;Work

PROJECT_TITLE: Physical Biology and Deep Learning for Antibiotic Resistance and Discovery

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: This discovery project will discover the physical forces dictating the native conformations of membrane proteins and their interactions with lipid bilayers. The knowledge gained from this research will contribute to the mechanisms of protein misfolding diseases, enable the rational design of therapeutics to modulate protein conformations, will be useful in the computational modeling of protein structures, and provides a biophysical and chemical basis for the design of proteins with novel functions.

PI_NAMEs: FLEMING, KAREN G. (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Biology;Biophysics;Catalysis;Chemicals;Computational algorithm;Computer Models;Databases;Disease;driving force;Equilibrium;Hydrogen Bonding;Investigation;Knowledge;Lipid Bilayers;Membrane Proteins;Modeling;Molecular;Molecular Conformation;novel;Phospholipids;Physical Chemistry;Protein Conformation;Protein Engineering;protein folding;protein misfolding;protein structure;Proteins;rational design;Research;simulation;Solvents;Structure;Therapeutic;Training;Vertebral column;Water

PROJECT_TITLE: Forces Driving Membrane Protein Folds


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Although genome-wide association studies have been predominantly focused on European populations in recent years, understudied populations such as the Native Hawaiians may provide genetic insights due to their unique population history and different disease incidence rates. The proposed research will provide genomic resources specific to the Native Hawaiian community to enable systematic genetic analysis in this population and reduce the barriers of future studies in other related populations.

PI_NAMEs: DINH, BRYAN LY (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Admixture;African American population;Alleles;American;Biotechnology;Cardiovascular Diseases;Characteristics;Chromosome Mapping;cohort;Communities;Complex;Cost efficiency;Data;design;Detection;Disease;disorder risk;Disparity;Drops;European;European ancestry;experience;Frequencies;Functional disorder;Future;Gene Frequency;Genetic;genetic analysis;genetic association;Genetic Markers;Genetic Recombination;genetic resource;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome resource;genome wide association study;Genomic Segment;Genomics;Genotype;Goals;Haplotypes;Hawaii;Hawaiian population;Health;High Prevalence;human disease;identity by descent;Immigration;improved;Incidence;Individual;insight;Investigation;Island;Latino;Linkage Disequilibrium;Maps;Methods;Minority Groups;Morphologic artifacts;Native Hawaiian;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Participant;Polynesian;Population;Population Genetics;Population Sizes;Process;Public Health;rare variant;Recording of previous events;Research;research and development;Research Design;Research Infrastructure;Resource Development;Resources;Risk;Risk Assessment;Sample Size;Scientist;Structure;Technology;Testing;theories;tool;trait;Underserved Population;Variant;Work

PROJECT_TITLE: Genomic resources and references for genetic investigation of an understudied population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative – Overall Osteoporosis is a major public health problem in our aging population. The over-arching goal of this center of research translation (CORT) is to understand how bone-building osteoporosis medications work in order to develop ‘next generation’ strategies to treat this disease. To accomplish this goal, we will apply cutting-edge methods to study the effects of such medications on key cell types in bone: stem cells and osteocytes.

PI_NAMEs: WEIN, MARC NATHAN (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Acceleration;Accounting;Affect;aging population;Agonist;Anabolic Agents;Anabolism;Antibodies;Antibody Therapy;Bioinformatics;Biology;Biomechanics;bone;Bone Diseases;Bone Formation Stimulation;Bone Marrow;bone mass;Bone Matrix;Bone Resorption;cell type;Cells;Center for Translational Science Activities;Clinical;Clinical Research;Cloud Computing;college;Communication;Communities;computational platform;cortical bone;cost;Data;Data Set;Disease;Epidemiology;Equilibrium;experience;Flow Cytometry;Forteo;fracture risk;fragility fracture;Gene Modified;gene network;Genes;Genetic;Genetic Variation;Genomics;Goals;Hip Fractures;Histopathology;Human;human data;Human Genetics;improved;Infrastructure;innovation;Institution;International;Investigation;Knockout Mice;knowledge translation;London;Mediating;medical schools;Mesenchymal;Methods;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Profiling;Monoclonal Antibodies;mouse genetics;mouse model;multidisciplinary;Mus;next generation;novel;optimal treatments;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;parathyroid hormone (1-34);Parathyroid Hormone Receptor;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Population;Postmenopausal Osteoporosis;pre-clinical;Pre-Clinical Model;Process;progenitor;Public Health;Research;Research Personnel;response;Risk;Role;Sampling;side effect;single-cell RNA sequencing;skeletal;skeletal stem cell;stem cell biology;stem cells;Testing;Therapeutic;Time;transcriptome sequencing;transcriptomics;translational research program;treatment response;treatment strategy;Woman;Work

PROJECT_TITLE: Center of Research Translation on Osteoporosis Bone Anabolic Therapies


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Hypertension is a major cause of global mortality and a primary modifiable risk factor for renal, cardiovascular and cerebrovascular disease. The present studies will address a significant knowledge gap by directly assessing the mechanisms whereby immune cells lead to salt-sensitive hypertension and kidney damage. Results of this work will transform the understanding of immune mechanisms in salt-sensitive hypertension by utilizing novel animal models and approaches, revealing new paradigms, and providing insight with the potential to transform clinical/therapeutic approaches for the treatment of disease.

PI_NAMEs: MATTSON, DAVID L. (contact);POLICHNOWSKI, AARON JAMES

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Anesthesia procedures;Animal Experiments;Animal Model;Animals;Attenuated;Blood Pressure;blood pressure elevation;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Carnitine;CD4 Positive T Lymphocytes;Cells;Cerebrovascular Disorders;Clinical;Conscious;Consumption;Dahl Hypertensive Rats;Data;Development;Diet;Dietary Component;Dietary Proteins;Disease;Exhibits;experimental study;feeding;Free Radicals;Gene Expression;Glomerular Filtration Rate;Grain;gut microbiota;Health Benefit;Human;human disease;human model;Hypertension;hypertensive;hypertensives;Immune;immune activation;Immunity;Individual;Infiltration;Inflammation;insight;Kidney;Kidney Diseases;kidney vascular structure;Knowledge;Lead;Link;Mediating;Mediator;microbial;modifiable risk;mortality;NADPH Oxidase;novel;Organ;Patients;Phagocytes;Phenotype;Plant Proteins;Plasma;Play;Population;Production;Propionates;protein intake;Proteins;Publishing;Rattus;renal damage;Renal function;Resistant Hypertension;Risk Factors;Rodent Model;Role;salt sensitive;salt sensitive hypertension;Severity of illness;Sodium;Sodium Chloride;Source;T-Lymphocyte;Testing;Therapeutic;Vascular resistance;Work

PROJECT_TITLE: Gut Metabolites, T cells, and Salt-Sensitive Hypertension

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Osteoporosis

PHR: Project Narrative – Administrative Core The Administrative Core will support the scientific missions of this Center of Research Translation. To serve this function, the Administrative Core will provide key administrative and oversight support so CORT investigators can focus on collaborative translational science. In addition, the Administrative Core will oversee awarding pilot and feasibility grants to further enhance the scientific mission of the CORT.

PROJECT_TERMS: Acceleration;Advisory Committees;Anabolic Agents;Award;Bioinformatics;Biology;bone;Bone Formation Stimulation;Capsicum;catalyst;Center for Translational Science Activities;Clinical;college;Communication;Communities;Data;Development;Genomics;Goals;Grant;Human;Human Resources;improved;Infrastructure;Institution;inter-institutional;International;Journals;knowledge translation;Leadership;London;medical schools;meetings;Mission;Molecular Mechanisms of Action;multidisciplinary;Mus;novel therapeutic intervention;Osteoblasts;Osteocytes;Osteoporosis;Patient Recruitments;professor;progenitor;programs;Reporting;Research;Research Personnel;Resources;response;Role;Scientist;Series;skeletal;Structure;success;symposium;Teleconferences;Time;Trans-Omics for Precision Medicine;transcriptomics;Translational Research;translational research program;Travel;Visit;Work

PROJECT_TITLE: Admin Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Myotendinous junctions are susceptible to traumatic muscle injury and myotendinous rupture, and existing treatments for these injuries are not always effective. The proposed research directly addresses the major goal of the NIH: i.e. essential knowledge will be gained about specific injury conditions that will have an impact on the health of patients. The approaches developed here have direct relevance to treatment strategies, as iPSC-derived tissue implants are a real future possibility for these injury conditions.

PI_NAMEs: SUZUKI, MASATOSHI  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Anatomy;Biology;Biomedical Engineering;Biomimetics;bone;Cell Culture System;Cells;Coculture Techniques;Cues;Data;Development;effective therapy;Effectiveness;Engineering;Experimental Models;Extracellular Matrix;Future;Goals;Health;Human;human disease;human induced pluripotent stem cells;human tissue;Implant;implantation;in vitro Model;induced pluripotent stem cell;injured;Injury;injury and repair;insight;Knowledge;Laboratories;mechanical load;Mechanics;Methods;Modeling;Molecular;Muscle;muscle engineering;muscle progenitor cell;muscle repair;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal System;Natural regeneration;novel;Organ Model;Organoids;Pathology;Patients;Pattern;personalized medicine;Physiological;Predisposition;progenitor;Property;Publishing;Rattus;reconstruction;regenerative therapy;repaired;Research;Role;Rupture;scaffold;Signal Transduction;Signaling Molecule;Site;Skeletal Muscle;Societies;stem cell biology;stem cell derived tissues;stem cell model;stem cells;Stretching;Structure;Tendon Injuries;Tendon structure;Testing;tissue culture;Tissue Engineering;Tissues;transmission process;treatment strategy;two-dimensional;United States National Institutes of Health;Work

PROJECT_TITLE: Stem cell-based tissue engineering for myotendinous junction modeling and repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Independent of initial cause of injury, patients with acutely injured lungs are at increased risk of secondary bacterial lung infection, which prolongs recovery and increases mortality in these patients. We have developed a new approach for culturing bacteria in conditions which mimic the healthy and/or injured lung environment, providing an accurate and convenient way to investigate why the injured lung is more susceptible to secondary bacterial pneumonia. This project aims to determine which nutrients in injured lungs support the growth of pneumonia-associated bacteria, which will provide a scientific basis for the development of clinical interventions that prevent and treat lung infections and, ultimately, improve clinical outcomes for patients with acute lung injury.

PI_NAMEs: BAKER, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Lung Injury;Award;Bacteria;bacterial community;bacterial fitness;Bacterial Infections;Bacterial Pneumonia;Bioinformatics;Biological;Biological Assay;Blood-Air Barrier;Bronchoalveolar Lavage Fluid;Carbohydrates;Cessation of life;Clinical;clinical development;Coculture Techniques;Communication;Complement;Complication;Critical Illness;Data;Development;Disease;dysbiosis;Edema;Enabling Factors;Environment;Etiology;experimental study;fitness;Frequencies;Gene Expression;Gene Expression Profiling;Genes;Glucose;Goals;Growth;Health;host microbiome;Immune;Immunologics;Impairment;improved;In Vitro;injured;Injury;Intervention;Iron;Knock-out;Knowledge;Leadership;Liquid substance;Lung;Lung infections;lung injury;Mass Fragmentography;Metabolic Pathway;metabolomics;microbial;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;novel;novel strategies;Nutrient;Nutrient availability;Outcome;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patient-Focused Outcomes;Patients;Pneumonia;predict clinical outcome;Predisposition;prevent;Proteins;Pseudomonas aeruginosa;Recovery;Research;Research Personnel;respiratory;Respiratory Tract Infections;Risk;Saline;Secondary to;Serum;Shapes;skills;Staphylococcus aureus;System;targeted treatment;Testing;Tissue-Specific Gene Expression;Training;training opportunity;transcriptome sequencing;United States;uptake

PROJECT_TITLE: Determining the Injury-Associated Microbial Nutrients that Facilitate Secondary Bacterial Infection in Acutely Injured Lungs


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Human Genome;Osteoporosis;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Project Narrative – Bioinformatics Core The goal of this Bioinformatics Core is to support statistical and bioinformatics analyses to study the effects of osteoporosis anabolic therapies on osteoblast progenitors as well as osteocytes in clinical and pre-clinical studies. To accomplish this goal, we will perform computational analysis on single-cell RNA-seq and bulk RNA-seq obtained from post-menopausal women and female mice treated with either sclerostin inhibitor or PTH. We will then prioritize genes regulating bone formation via human genetic variation association analyses; and knockout mice with deeply skeletal phenotypes.

PI_NAMEs: HSU, YI-HSIANG  (contact)

PROJECT_TERMS: Adult;Affect;Anabolic Agents;Antibodies;Architecture;biobank;Bioinformatics;bioinformatics pipeline;Biological Process;Biology;Biopsy;bone;bone cell;Bone Density;Bone Marrow Aspiration;Bone structure;cell type;Cells;Center for Translational Science Activities;Clinical;clinical phenotype;Clinical Research;Cloud Computing;computational platform;Computer Analysis;Data;Data Analyses;Data Analytics;Data Collection;data management;data quality;Data Set;design;Development;Environment;FDA approved;Female;Femur;Forteo;Foundations;Fracture;fracture risk;Future;Gene Expression;Gene Expression Profile;Genes;genetic association;Genetic study;genetic variant;Genetic Variation;genome sequencing;Goals;Human;human data;Human Genetics;Human Genome;inhibitor;innovation;International;Knockout Mice;Late Effects;long bone;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Profiling;Morphology;Mouse Strains;Mus;National Heart, Lung, and Blood Institute;novel;Osteoblasts;Osteocalcin;Osteocytes;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Ovariectomy;parathyroid hormone (1-34);Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;phenotypic data;Physiologic pulse;Pilot Projects;Postmenopausal Osteoporosis;Postmenopause;pre-clinical;preclinical study;precursor cell;prevent;Process;progenitor;Quality Control;Reporting;Research Personnel;Research Project Grants;Resources;response;Sampling;side effect;single-cell RNA sequencing;skeletal;Skeleton;stem cell biology;Techniques;tibia;Time;time use;Trans-Omics for Precision Medicine;transcriptome;transcriptome sequencing;transcriptomics;treatment effect;treatment strategy;whole genome;Woman;women's treatment

PROJECT_TITLE: Bioinformatics Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MERCED

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: Project Narrative Circadian clocks provide an accurate internal representation of local time under a range of different physiological temperatures and cellular energy levels. However, the molecular mechanisms by which clocks compensate for such variations remain experimentally unresolved in any organism. Thus, the overall goal of this application is to fill these fundamentally important knowledge gaps and thereby significantly advance the field of chronobiology with a lasting impact.

PI_NAMEs: LIWANG, ANDY  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Temperature and metabolic compensation mechanisms in a circadian clock system

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: We have discovered that plasma-derived extracellular vesicles (EVs) isolated from people living with HIV (PLWH) recapitulate the effects of HIV positivity on the development of HIV-associated cardiovascular disease (CVD) and the potential EV-associated miRNAs (EV-miRs) that mediate this effect. In this proposal, we will use novel tailored EVs generated by genetic modification of bone marrow mesenchymal stromal cells to determine if targeting these candidate EV-miRs will abrogate the effects of HIV positivity in the CVS and characterize the underlying molecular mechanisms/pathways whereby EVs/TEVs effect atherogenesis.

PI_NAMEs: DONG, CHUNMING  (contact);DYKXHOORN, DEREK MICHAEL;JAYAWEERA, DUSHYANTHA ;WANG, LIYONG

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Acquired Immunodeficiency Syndrome;Adverse effects;Affect;age acceleration;antagonist;antiretroviral therapy;Apolipoprotein E;Apoptosis;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biological;Body Fluids;Bone Marrow;Bone Marrow Cells;candidate validation;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Pathology;Cardiovascular system;CD4 Lymphocyte Count;Cell Communication;Cell Separation;cell type;Cells;Chronic;clinical care;Data;Development;Distant;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Equilibrium;exosome;Exposure to;extracellular vesicles;Foundations;Genes;Genetic;Goals;Grant;high risk;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HMGA2 gene;Human;immune activation;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;Injury;injury and repair;latent HIV reservoir;Lipids;Liquid substance;lonely individuals;Mediating;Mediator;mesenchymal stromal cell;Messenger RNA;MicroRNAs;migration;Modification;Molecular;Morbidity - disease rate;mortality;Mus;nanosized;novel;overexpression;Pathway interactions;peripheral blood;Persons;Plasma;premature;Prevention strategy;Process;Proliferating;Proteins;Publishing;Quality of life;reconstitution;Regulation;Resistance;Role;Sampling;senescence;Small RNA;Smooth Muscle Myocytes;Solid;Testing;transcriptome;transcriptome sequencing;treatment strategy;Urine;Vascular Endothelial Cell;vascular injury;Vesicle;Viral;Viral Load result;virtual;Writing

PROJECT_TITLE: The role of extracellular vesicle-associated MicroRNAs in HIV-associated atherosclerosis

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chemoresistance in triple negative breast cancer (TNBC) leads to extremely poor patient outcomes and there are no approved targeted therapies with which to treat residual tumors that persist following chemotherapy. Based on our preliminary findings that TNBCs rely on mitochondrial metabolism to evade chemotherapy, we now aim to delineate the functional role of mitochondrial structural dynamics in TNBC metabolic adaptations and chemoresistance. Our long-term goal is to therapeutically target regulators of mitochondrial structure in chemo refractory TNBCs.

PI_NAMEs: ECHEVERRIA, GLORIA VITTONE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Chemotherapy;Adjuvant Therapy;Anthracycline;Automobile Driving;Biopsy;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Patient;Carbon;Cell Cycle;Cells;Cessation of life;Chemoresistance;chemotherapy;Data;Disease;Equilibrium;Face;Generations;Genetic;Goals;Guanosine Triphosphate Phosphohydrolases;high risk;Human;Immune system;Immunocompetent;improved;In Vitro;in vivo;inhibitor;insight;knock-down;Life;Machine Learning;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mathematics;Measures;Mediating;Medical Oncology;Metabolic;Metabolism;Mitochondria;mitochondrial genome;mitochondrial metabolism;mouse model;Mus;mutant;Neoadjuvant Therapy;neoplastic cell;novel;Oncogenic;Optic atrophy 1;Organelles;Organoids;Oxidative Phosphorylation;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Platinum;Play;Population;preference;Process;Protein Dynamics;Proteins;Recurrence;Refractory;Regulation;Residual Neoplasm;Residual state;response;Role;Scanning Electron Microscopy;Signal Pathway;Structure;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;therapy resistant;Tissue imaging;transcriptomics;Transmission Electron Microscopy;Transplantation;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor-immune system interactions;tumorigenic;Visualization

PROJECT_TITLE: Metabolic adaptation in residual triple negative breast cancer following chemotherapy

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Genetics;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Project Narrative – Project 1 The goal of this project is to understand the effects of osteoporosis anabolic therapies on osteoblast stem cells. To accomplish this goal, we will study stem cells isolated from humans and mice. We will apply targeted and unbiased approaches to understand how osteoporosis medications stimulate bone formation, and to understand why this bone anabolic effect can diminish over time.

PI_NAMEs: KRONENBERG, HENRY M. (contact)

PROJECT_TERMS: Accounting;Address;aged;aging population;Agonist;Anabolic Agents;Anabolism;Antibodies;antibody detection;Antibody Therapy;Antigens;Apoptosis;aspirate;Bioinformatics;Biopsy;bone;Bone Formation Stimulation;Bone Marrow;Bone Marrow Aspiration;bone mass;Bone Resorption;cell bank;Cell Separation;Cells;cellular targeting;Center for Translational Science Activities;Clinical;Clinical Research;Color;Complement;Core Biopsy;Data;Disease;Early treatment;Equilibrium;exhaustion;Female;Flow Cytometry;Forteo;Fracture;fracture risk;fragility fracture;Future;gene conservation;gene network;gene regulatory network;Goals;Heterogeneity;Hip Fractures;Human;Marrow;Mesenchymal;Modeling;Molecular;Molecular Target;Mus;next generation;novel;optimal treatments;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;Osteoporotic;osteoprogenitor cell;Parathyroid Hormone Receptor;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;Play;Population;Postmenopause;Pre-Clinical Model;Prevention;progenitor;Proliferating;prospective;Public Health;response;Role;Sampling;side effect;single-cell RNA sequencing;skeletal;skeletal stem cell;stem cell biology;stem cell expansion;stem cell population;stem cells;Stromal Cells;Subgroup;Surface;Testing;Time;transcriptomics;Translational Research;treatment effect;treatment response;Woman;women's treatment

PROJECT_TITLE: The role of osteoblast progenitors in response to bone anabolic agents


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Services;Hearing Loss;Patient Safety;Prevention;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative The role of hearing loss in health care outcomes such as delirium and health care utilization, possibly mediated via poor patient-provider communication and sensory deprivation pathways, is poorly understood. This study characterizes these associations in epidemiologic datasets and clinical samples and explores a low-cost, low- risk sustainable solution to address hearing loss in the inpatient setting. This Award lays the groundwork for large clinical trials that investigate systematically addressing hearing loss to improve health care outcomes and potential translation of research to improve patient-care for the millions of older adults with hearing loss.

PI_NAMEs: REED, NICHOLAS SALVATORE (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Admission activity;Adult;Aging;amplification device;Applications Grants;Atherosclerosis Risk in Communities;auditory stimulus;Award;beneficiary;Biometry;Brain;California;care outcomes;care seeking;career;Caring;Clinical;clinical practice;Clinical Research;Clinical Trials;cognitive load;Collaborations;Communication;Communication impairment;Confusion;cost;Data;Data Set;Dedications;Delirium;design;Development;Discipline of Nursing;Educational workshop;Environment;epidemiologic data;Epidemiology;epidemiology study;Equipment;Evaluation Research;experience;Faculty;Foundations;Funding;Gerontology;Goals;Head and Neck Surgery;Health;Health Care Costs;health care quality;health care service utilization;Health Policy;Health system;Healthcare;Healthcare Systems;Hearing;Hearing Aids;hearing impairment;hearing measurement;high risk;hospital readmission;Hospitalization;Hospitals;implementation measures;implementation science;improved;Incidence;Indiana;Inpatients;Instruction;Intervention;intervention program;Intervention Studies;Interview;K-Series Research Career Programs;Length of Stay;Link;Measurement;Measures;Mediating;Medical;medical schools;Medicare;Medicare claim;meetings;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;multidisciplinary;older adult;Otolaryngology;Outcome;Outcomes Research;Pamphlets;Pathway interactions;Patient Care;patient oriented;patient-clinician communication;Patients;Peripheral;Persons;pilot test;post implementation;Practice based research;Presbycusis;prevent;Prevention;Process;process evaluation;professor;programs;protective factors;Publications;Quality of Care;readmission rates;Research;responsible research conduct;Risk;Risk Factors;Role;Sampling;San Francisco;satisfaction;Schedule;screening;Screening procedure;screening program;secondary analysis;Sensory Deprivation;Shapes;Signal Transduction;skills;Societies;staff intervention;Surveys;theories;Time;tool;Training;translational potential;Translational Research;trial design;Universities;webinar;working group

PROJECT_TITLE: The Role of Hearing Loss in Health Care Outcomes.

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetic Testing;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE Recently, the Scz Exome Meta-Analysis (SCHEMA) Consortium has identified genes with ultra-rare coding variants that each confer substantial risk for Scz, hypothesized to be in part by loss of protein expression. The PI, Dr. Pan Li, has extensive experience with gene editing and induced pluripotent stem cells, including development of an improved method for seamless introduction and removal of mutations, and proposes to test the effects of these mutations in edited human iPS cells. We hypothesize that understanding the cellular phenotypes and altered signaling pathways evoked by the SCHEMA mutations will clarify the cellular pathogenesis of subtypes of schizophrenia, and provide potential therapeutic targets.

PI_NAMEs: LI, PAN  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Affect;Autopsy;Biological Assay;Brain;Cell Line;Cells;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Code;comparison control;Complex;Copy Number Polymorphism;CUL1 gene;Development;Diagnostic;Disease;electrical property;Electrophysiology (science);Excision;excitatory neuron;exome;experience;experimental study;Future;Gene Expression;gene function;Generations;Genes;Genetic;genetic architecture;Genetic Engineering;genetic risk factor;genetic variant;Genotype;HERC1 gene;homologous recombination;human female;human induced pluripotent stem cells;improved;Individual;induced pluripotent stem cell;Interdisciplinary Study;Karyotype determination procedure;knock-down;Length;Location;loss of function;Major Mental Illness;male;Meta-Analysis;Methods;Microscopy;multi-electrode arrays;mutant;Mutate;Mutation;Mutation Analysis;N-terminal;Neurites;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;new therapeutic target;novel strategies;overexpression;patch clamp;Pathogenesis;Pathway interactions;Phenotype;pluripotency;Point Mutation;polygenic risk score;protein aggregation;protein expression;Protein Truncation;Proteins;Proteome;Proteomics;proteostasis;rare variant;Research;Risk;Schizophrenia;Signal Pathway;Signal Transduction;Structure;Synapses;System;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Functional characterization of schizophrenia rare variants using genetically engineered human iPSCs


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: The brain cancer glioblastoma (GBM) contains invasive cells that contribute to recurrence after surgery and chemoradiation. We have discovered a pathway involving the phosphatase PTP- PEST that drives GBM cell invasion and we will develop new strategies to target it for therapy.

PI_NAMEs: MCCARTY, JOSEPH H (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Amino Acid Motifs;Angiogenesis Inhibitors;BCAR1 gene;bevacizumab;Biochemical;Brain;Brain Neoplasms;cancer cell;Cell Culture System;cell growth;Cell Proliferation;Cells;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cullin Proteins;Data;Data Correlations;effective therapy;Equilibrium;Event;Excision;experimental study;fluorescence imaging;Focal Adhesions;gene-editing approach;Genetic;genetic approach;Genetically Engineered Mouse;Glioblastoma;Glioma;Gliomagenesis;Growth;Human;in vivo Model;inducible gene expression;inhibitor;Invaded;Lesion;Ligase;Link;live cell imaging;Malignant - descriptor;Malignant neoplasm of brain;Mediating;Modality;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mutate;neoplastic cell;Oncogenes;Operative Surgical Procedures;Outcome;Pathway interactions;patient response;Patients;Pattern;Pest Control;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Population;pre-clinical;protein complex;Protein Dephosphorylation;protein expression;Protein Tyrosine Phosphatase;Proteins;Proteomics;PTPN12 gene;recruit;Recurrence;Recurrent tumor;Refractory;Reporting;Resected;Resistance;Resolution;Role;Sampling;Scaffolding Protein;Signal Pathway;Signal Transduction;Signaling Protein;Site;System;temozolomide;Tertiary Protein Structure;Testing;treatment response;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Tyrosine;Ubiquitin;Ubiquitination;valosin-containing protein

PROJECT_TITLE: Analyzing Adhesion and Signaling Functions for PTPN12 in Invasive Glioma Cells

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: NARRATIVE Atrial fibrillation (AF) is the most common heart rhythm disturbance seen in the clinic and is a major cause of morbidity and mortality. Current treatments for AF are inadequate and are marred by dangerous side effects. Here, we will utilize protein engineering approaches to provide proof of concept for the design of new therapeutic modalities that are safe and effective in stopping AF and restoring normal sinus rhythm.

PI_NAMEs: JALIFE, JOSE S;NOUJAIM, SAMI FOUAD (contact);TENG, MICHAEL N

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acetylcholine;Action Potentials;Address;Affect;Amino Acids;Anti-Arrhythmia Agents;Arrhythmia;Atrial Fibrillation;Avidity;Biological;Biomedical Engineering;Cardiac;Cells;Chimera organism;Chimeric Proteins;Chronic;Clinic;Clinical;Dangerousness;Data;design;Development;Electrophysiology (science);epigenomics;European;experimental study;Frequencies;Genomics;Goals;Heart;Heart Atrium;Heart Diseases;heart rhythm;Human;Idiopathic Thrombocytopenic Purpura;Immunoglobulin Fragments;Immunoglobulin G;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;Ion Channel;Length;Libraries;Link;Maps;Modality;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Muscle Cells;mutant;Mutation;Myopathy;next generation;novel;novel therapeutics;old mice;Optics;patch clamp;Peptides;peptidomimetics;Perfusion;Pharmacotherapy;porcine model;Potassium;Prevalence;prevent;Protein Engineering;Protein Fragment;Proteomics;Refractory;Rodent;Safety;side effect;Sinus;Specificity;structural determinants;Structure;synthetic peptide;Testing;Therapeutic;Therapeutic Effect;Thrombopoietin;Variant;Venoms;Ventricular;Yeasts

PROJECT_TITLE: Peptibodies As Novel Therapies in Atrial Fibrillation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Police officers frequently interact with individuals with serious mental illnesses (SMI), as well as those experiencing suicidality or psychiatric crisis, either during a crisis response, or during routine patrol duties. They need specialized skills to safely and effectively manage these interactions, and the 40-hour Crisis Intervention Team (CIT) mental health training is the premier approach that has been implemented in thousands of U.S. communities; yet, a randomized, controlled trial has never been conducted to assess its effectiveness on officers’ skills and behaviors. A rigorous, multi-site trial that thoroughly assesses the impact of CIT training on officers’ actual verbal crisis de-escalation skills and non-verbal physical behavior, their use of procedural justice, and their disposition-related decision-making will inform decision-makers in jurisdictions across the country on how best to prepare officers to effectively play their role in the mental health crisis system (when needed) and to divert individuals from the criminal justice system whenever possible.

PI_NAMEs: COMPTON, MICHAEL T (contact);WATSON, AMY C

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Area;arm;Attitude;Behavior;Behavior Control;Blinded;body position;Caring;Characteristics;collaborative approach;Communities;Country;Criminal Justice;Crisis Intervention;Data;Decision Making;demographics;design;Effectiveness;effectiveness evaluation;efficacy evaluation;experience;experimental study;Exposure to;Familiarity;first responder;Funding;Geographic Locations;Health;health training;Hour;improved;Individual;interest;Justice;Knowledge;Law Enforcement;Link;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mental Health Services;Modeling;Motivation;multi-site trial;National Institute of Mental Health;Nature;non-verbal;Outcome;Pathway interactions;Patient Self-Report;peer;Performance;Persons;Play;Police;Police officer;Preventive service;primary outcome;Quasi-experiment;Randomized;Randomized, Controlled Trials;Research;response;Role;secondary outcome;Self Efficacy;Services;severe mental illness;Site;skills;Specialist;Standardization;suicidal;System;Testing;Time;Training;verbal;Work

PROJECT_TITLE: A Randomized, Controlled Trial of Crisis Intervention Team (CIT) Mental Health Training for Police Officers


NIH_SPENDING_CATS: Aging;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Osteoporosis is treated with two classes of drugs: Anti-resorptives (bisphosphonates, Prolia®) or anabolics, and their sequential or combined use. Anabolics include PTH (Forteo®) and sclerostin antibody (Scl-Ab, Evenity®). Both increase BMD and reduce fracture risk but have limitations and their activity wanes over time. Understanding their anabolic action and the waning over time will help identify novel drugs. This application focuses on the role of osteocytes, the most abundant cells, embedded deep in bone, and “orchestrators” of bone remodeling and mass, in mediating the effects of PTH1-34 and Scl-Ab in humans and mice.

PI_NAMEs: BARON, ROLAND E (contact)

PROJECT_TERMS: Address;Affect;analog;Antibodies;Behavior;Bioinformatics;Biology;Biopsy Specimen;bisphosphonate;bone;Bone Diseases;bone fragility;Bone Marrow;bone mass;Bone remodeling;cell behavior;Cells;Center for Translational Science Activities;Data;Deposition;Forteo;fracture risk;Gene Expression;Goals;Homeostasis;Human;Imaging Techniques;improved;Injections;Investigation;Link;Mediating;Methods;microCT;Modeling;Molecular;Morphology;mouse model;Mus;new therapeutic target;novel;novel therapeutics;Osteocytes;Osteoporosis;Osteoporotic;osteoprogenitor cell;Outcome;parathyroid hormone (1-34);parathyroid hormone-related protein;Pathway interactions;Pharmaceutical Preparations;Play;Postmenopause;preclinical study;Preparation;prevent;Process;receptor;Regulation;Research;response;Role;Safety;Sampling;skeletal;skeletal stem cell;Skeleton;Source;Testing;Therapeutic;Three-dimensional analysis;Time;TNFSF11 gene;transcriptome;transcriptome sequencing;treatment response;treatment strategy;ultra high resolution;Woman

PROJECT_TITLE: The role of the osteocyte in responses to osteoporosis anabolic treatment in humans and mice


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PI_NAMEs: ANDERSON, DAVID J (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Address;Adult;Arousal;base;Behavior;Biogenic Amines;Biological Assay;Brain;Calcium;candidate identification;Cells;conditioning;Courtship;Data;Decision Making;Dopamine;Drosophila genus;Emotions;Enzymes;experimental study;Fluorescent in Situ Hybridization;FOS gene;Genetic;Genetic Models;Goals;Grant;Homologous Gene;Image;Immediate-Early Genes;In Situ Hybridization;Insecta;Interneurons;Label;Learning;Link;male;Mediating;model organism;Morphology;Motivation;Mushroom Bodies;Nature;Negative Valence;neural circuit;neurobiological mechanism;Neuromodulator;Neurons;neuropeptide F;Neuropeptides;neuroregulation;Neurotransmitters;Norepinephrine;Octopamine;Odors;optogenetics;Phylogeny;Play;Population;Positive Valence;preference;psychostimulant;Publications;response;Rewards;Rodent;Role;Self Administration;social;Social Behavior;Social Controls;Stimulus;System;Techniques;Testing;Time

PROJECT_TITLE: Imaging neuromodulation in the brain

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Although tremendous progress has been made in treatment modalities of acute myeloid leukemia (AML),  there is the necessity to improve and develop novel therapeutic approaches. Recently, we have  identified that DNA polymerase theta (Polθ) is a key player in a novel DNA repair pathway that is  essential for the proliferation of leukemia cells, but expendable in normal cells.  Selective inhibitors of Polθ have been identified in our laboratories. We aim to  develop a drug-like Polθ inhibitor that will selectively kill AML cells, while sparing  healthy cells.

PI_NAMEs: POMERANTZ, RICHARD T;SKORSKI, TOMASZ  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;AML1-ETO fusion protein;Biochemical;Biological Assay;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;cBioPortal;CD34 gene;Cells;chemotherapy;Cisplatin;Clinical Trials;cohort;CRISPR/Cas technology;Cytotoxic agent;Data;Databases;design;Development;Disease remission;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA-Directed DNA Polymerase;Dominant-Negative Mutation;Double Strand Break Repair;Drug Kinetics;Drug Targeting;FLT3 gene;Gene Expression;Gene Mutation;Genes;Genetic;Genotoxic Stress;high throughput screening;homologous recombination;homologous recombination deficiency;improved;In Vitro;Individual;Induced Mutation;Infection;inhibitor;Knock-out;Laboratories;Left;leukemia;Leukemic Cell;leukemic stem cell;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Messenger RNA;MLL-AF9;Modality;Modeling;Mus;mutant;Mutate;Mutation;Mutation Analysis;neoplastic cell;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;older patient;PALB2 gene;paralogous gene;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;prevent;Prognosis;Proliferating;Proteins;RAD52 gene;Relapse;replication stress;Reporting;Resistance;response;Role;Sampling;small hairpin RNA;small molecule inhibitor;Solid Neoplasm;standard care;Stem cell transplant;Structure;success;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic evaluation;tool;Toxic effect;tumor;Tyrosine Kinase Inhibitor;Western Blotting;Xenograft procedure

PROJECT_TITLE: PolQ as a novel therapeutic target in AML

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Even though respiratory coronavirus disease 2019 (COVID-19) vaccines are currently available, therapeutics for treatments are still very valuable to combat SARS-CoV-2. More importantly, SARS-CoV-2 keeps making various mutants with higher infection rates than previous ones, threatening public health. We propose a novel therapeutic approach to selectively target SARS-CoV-2 infected and susceptible cells and inhibit virus replication using advanced exosomes carrying innovative and selective MMP14 as a potential therapeutic.

PI_NAMEs: HAN, KYUYEON  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;ACE2;Anti-viral Agents;antiviral drug development;Binding;Biochemistry;Biophysics;biosafety level 3 facility;Catalytic Domain;Cell Physiology;Cells;Chymase;Clinical;combat;Cornea;Coughing;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 treatment;COVID-19 vaccine;current pandemic;Development;Disinfectants;Drug Targeting;effectiveness evaluation;engineered exosomes;Engineering;Exhibits;exosome;experience;experimental study;Extracellular Matrix;Eye;Family;Goals;Hand;improved;In Vitro;infection rate;influenzavirus;innovation;Kinetics;Location;Masks;Matrix Metalloproteinases;Mediating;member;Mesenchymal Stem Cells;Middle East Respiratory Syndrome Coronavirus;MMP14 gene;Molecular Biology;Molecular Biology Techniques;Molecular Virology;mutant;Nonstructural Protein;Nose;novel;novel therapeutic intervention;novel therapeutics;Oral cavity;overexpression;Papain;particle;Peptide Hydrolases;Peptides;Persons;Polyproteins;Predisposition;Process;Proteins;Public Health;Reporting;Research;respiratory;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 protease;SARS-CoV-2 spike protein;Site;Specificity;stem cell exosomes;Surface;Techniques;Testing;Therapeutic;Therapeutic Agents;transmission process;Vero Cells;Viral;virology;Virus;Virus Replication;Work;wound healing

PROJECT_TITLE: Development of MMP14-laden exosomes as a novel anti-SARS-CoV-2 therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  The U.S. blood supply is at risk due to the presence of emerging infectious diseases and reduced donation rates. In order to preserve the blood supply and protect the population, this application seeks to develop novel oxygen carrying solutions consisting of monodisperse, structurally well-defined recombinant polymerized hemoglobins that are safe and efficacious by screening these materials using an animal model with similar antioxidant status to humans.

PI_NAMEs: BUEHLER, PAUL WERNER;PALMER, ANDRE FRANCIS (contact);WOOD, DAVID W

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Animal Model;Animals;Antioxidants;Arteriosclerosis;Biocompatible Materials;biophysical techniques;Biotechnology;Blood;Blood Preservation;Blood Vessels;Blood Volume;Cardiac;Cattle;Cavia;Chemicals;Circulation;Clinical;Clinical Trials;Complex;Complex Mixtures;design;design and construction;Development;Diameter;Diet;dimer;Dose;Drug Kinetics;Electron Spin Resonance Spectroscopy;Emerging Communicable Diseases;endothelial dysfunction;Endothelium;Engineering;Enzymes;Erythrocytes;Event;Exhibits;Extravasation;Fatty acid glycerol esters;femoral artery;Generations;Glutaral;Goals;Hemoglobin;hemoglobin polymer;Hemorrhage;Heterogeneity;High Fat Diet;Human;hypertensive;Image;Impairment;Individual;Injury;innovation;intein;Laboratories;Light;manufacture;Measures;Membrane;Methods;Modeling;Modification;Molecular;molecular size;Molecular Weight;monomer;mutant;Myocardial Infarction;Nanostructures;Nitric Oxide;nonalcoholic steatohepatitis;novel;oxidative damage;Oxidative Stress Induction;Oxygen;Oxygen saturation measurement;oxygen transport;Phase III Clinical Trials;physical property;Physiological;Plasma;Polymers;Population;preclinical trial;primary endpoint;Proteins;Recombinants;Regulation;repaired;Reporting;Research;response;Reticuloendothelial System;Risk;RNA Splicing;Role;Sampling;screening;side effect;Signal Transduction;Structure;Sucrose;survival outcome;Systemic hypertension;Testing;Therapeutic;tissue injury;tissue oxygenation;Tissues;Toxic effect;Trans-Splicing;Transfusion;transfusion medicine;Translating;Ultrafiltration;Vascular blood supply;vascular injury;Vascular Permeabilities;vasoconstriction;Whole Blood Exchange Transfusion;Work

PROJECT_TITLE: Engineering a novel biomaterial for oxygen transport applications

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: Overall Indiana Alcohol Research Center (IARC) Binge and high-intensity drinking (BHID) are highly prevalent and constitute risk factors for developing an alcohol use disorder (AUD). The Indiana Alcohol Research Center (IARC) has a 34-year history of studying how responses to alcohol and genetic factors contribute to the risk of developing an alcohol use disorder. For this next 5-year period of study, the IARC plans a coordinated set of interdisciplinary studies of heritable brain and behavioral mechanisms that contribute to BHID.

PI_NAMEs: KAREKEN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Acute;Affect;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol research;alcohol response;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Experimentation;Animal Model;Animals;Automobile Driving;behavior influence;Behavioral;Behavioral Genetics;Behavioral inhibition;Behavioral Mechanisms;Brain;brain circuitry;breath alcohol measurement;Breeding;Collaborations;Communities;Computer Models;Consumption;Corpus striatum structure;Data;Development;Discipline;disorder risk;drinking;drinking behavior;Family;Family history of;Foundations;Genetic;Genetic Determinism;Glutamates;Goals;Health Personnel;Heritability;high intensity drinking;Human;human model;Inbred Strains Mice;Indiana;Individual;Information Dissemination;Inherited;insight;Insula of Reil;Intake;Interdisciplinary Study;Intoxication;Judgment;Knowledge;Medial;Mediating;multidisciplinary;Mus;neural;neurobiological mechanism;Neurobiology;neuroimaging;Neurosciences;Nucleus Accumbens;Pathway Analysis;Personality Traits;pharmacokinetic model;Policy Maker;Positioning Attribute;pre-clinical;preference;Prefrontal Cortex;prevent;Prevention;Production;rate of change;Rattus;Recording of previous events;Regulation;Research;Research Personnel;Rewards;Risk;Risk Factors;Rodent;Schools;Science;Self Administration;Services;Structure;tool;Work

PROJECT_TITLE: Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

PROJECT_TERMS: Alcohol consumption;alcohol exposure;alcohol research;alcohol response;Alcohols;Applications Grants;Budgets;Collaborations;Communities;Complex;Development;Educational workshop;Fostering;Genetic Determinism;Goals;graduate student;Grant;Indiana;Information Dissemination;Leadership;Link;Medical;Medical Students;Medicine;Mission;National Institute on Alcohol Abuse and Alcoholism;Neurology;Neurosciences;Occupational activity of managing finances;Outcome;Participant;Patients;Postdoctoral Fellow;programs;recruit;Research;Research Personnel;Resources;Schools;Science;Source;symposium;synergism;Universities;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Narrative Zika virus (ZIKV) is a re-emerging mosquito-borne Flavivirus that recently caused an outbreak in the Americas. The establishment of ZIKV transmission cycle in tropical/sub-tropical regions that are endemic to other close-related flaviviruses such as Dengue virus (DENV) has raised concerns, mainly by their cross-immunological interactions and the implications of this for development of severe clinical manifestations like Guillain-Barre Syndrome and the Congenital Zika Syndrome. Few is known about consequences of the immunological interaction between those viruses. This project aims to identify correlates of protection or pathogenesis in the complex immunological interactions between DENV and ZIKV using non- human primates as a model. Results from the work proposed here will have a huge impact in the ZIKV and DENV vaccines design and in the way we approach the diagnosis of these viral diseases and anticipate the epidemiological behavior during DENV or ZIKV epidemics in population with previous heterologous immunity.

PI_NAMEs: SARIOL, CARLOS A (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adult;Americas;Animal Model;Animals;Antibody-Dependent Enhancement;Antigen-Antibody Complex;Area;B-Lymphocytes;Behavior;Breeding;Caribbean region;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Immunity;Child;Clinical;Complement;congenital zika syndrome;cross immunity;cross reactivity;Cross-Priming;cytokine;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;design;Development;Diagnosis;Diagnostic Procedure;Disease Outbreaks;Epidemic;Epidemiology;Experimental Designs;experimental group;experimental study;Exposure to;Flavivirus;Guillain Barré Syndrome;Herd Immunity;Human;Immune;Immune response;Immune Sera;Immune system;Immunity;Immunocompetent;immunodeficiency;Immunodeficient Mouse;immunodeficient mouse model;Immunologics;immunoregulation;In Vitro;in vivo;Inbreeding;Infection;Inflammatory;Link;Macaca;Macaca mulatta;Mediating;Modeling;mosquito-borne;MS4A1 gene;Newborn Infant;nonhuman primate;Outcome;pathogen;Pathogenesis;Play;Population;Pregnancy;prevent;Primary Infection;Primates;protective effect;Publications;Research;response;Role;secondary infection;secondary outcome;Series;Serology;severe dengue;System;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Time;time interval;tool;transmission process;Vaccine Design;Viral;Viremia;Virus;Virus Diseases;Virus Replication;Work;ZIKA;Zika Virus;Zika virus vaccine;ZIKV disease;ZIKV infection

PROJECT_TITLE: Dengue-Zika: Correlates of Cross-Protection in Non-Human Primates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-C(02)]


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal will allow us to understand how blood-forming stem cells function in an organism. The knowledge gained from these studies will allow us to understand how stem cell function can be controlled and how it is affected in conditions such as aging or bone marrow transplantation.

PI_NAMEs: CAMARGO, FERNANDO  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Affect;Age;aged;Aging;aging population;aging process;Apical;Automobile Driving;Bar Codes;Behavior;Biological;Biological Assay;Biology;Blood;Bone Marrow Transplantation;cell behavior;Cell Lineage;Cells;Chromatin;clinically relevant;Clonal Expansion;Coupled;Data;Disease;Dissection;epigenomics;functional outcomes;Funding;Genetic;genetic approach;Genetic Transcription;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;Heterogeneity;Human;Impairment;In Situ;Individual;insight;Interdisciplinary Study;Knowledge;Label;Lentivirus;Link;Maintenance;Marrow;Measurement;Modeling;Molecular;Mus;Natural regeneration;novel;Organism;Outcome;Output;Physiological;Physiology;Population;premalignant;prevent;Process;progenitor;Property;Regulation;Research;Resolution;single cell ATAC-seq;single-cell RNA sequencing;Source;stem;stem cell function;stem cell population;stem cells;System;Testing;Time;tool;transcription factor;transcriptomics;Transplantation;Work

PROJECT_TITLE: Molecular regulation of native hematopoiesis

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Aging is a major risk factor in many chronic diseases, including cancer and heart disease. Due to the rapidly increasing population of individuals over the age of 65 in the U.S., there is an urgent need to better understand the molecular drivers of aging in order to delay or prevent the onset of these age-related diseases. My proposal aims to use replicatively aged Saccharomyces cerevisiae (budding yeast) as a model organism for studying the initiating events of aging, specifically the role of DNA double-strand breaks and age-dependent depletion of chromatin factors in genomic instability.

PI_NAMEs: POWER, LINDSEY N. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;Age of Onset;age related;age related changes;age-related disease;aged;Aging;Cardiovascular Diseases;cell age;Cell Nucleus;Cells;Centromere;ChIP-seq;Chromatin;Chromosomal Instability;chromosome loss;Chronic Disease;cohesin;Collaborations;Coupled;Diabetes Mellitus;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Maintenance;DNA Repair;DNA Repair Enzymes;DNA replication fork;Dose;Double Strand Break Repair;Doxycycline;drivers of aging;Elderly;Etiology;Event;experimental study;Frequencies;Gamma-H2AX;gel electrophoresis;Genetic Models;Genetic Transcription;Genome;genome integrity;Genome Stability;genome-wide;Genomic Instability;Goals;hallmarks of aging;healthspan;Heart Diseases;helicase;human old age (65+);Individual;inducible gene expression;insight;Laboratories;Lesion;life span;Link;Location;Magnetism;Malignant Neoplasms;Maps;Methods;Methyl Methanesulfonate;model organism;Modeling;Molecular;Nature;novel;Nuclear;Nuclear Proteins;overexpression;Phenotype;Population;prevent;Proteins;Proteomics;Protocols documentation;Publishing;Pulsed-Field Gel Electrophoresis;repair enzyme;repaired;Ribosomal DNA;Risk Factors;RNA Polymerase I;Role;Saccharomyces cerevisiae;Saccharomycetales;Site;Stress;System;Testing;Time;tool;Topoisomerase;Topoisomerase II;Topoisomerase Inhibitors;Type I DNA Topoisomerases;Work;yeast genome;Yeasts

PROJECT_TITLE: Aging induced DNA double-strand break analysis in yeast


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: GRAHAME, NICHOLAS JOSEPH (contact)

PROJECT_TERMS: Abstinence;addiction;Address;Affect;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol effect;alcohol preferring mice;alcohol research;alcohol response;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;animal colony;Animal Model;Animals;Behavior;Behavioral;Blood;Blood alcohol level measurement;Breeding;Characteristics;Clinical Treatment;Consumption;cost;Dependence;Development;Disparate;drinking;drinking behavior;drug testing;Environment;Environmental Risk Factor;Ethanol;Ethanol dependence;experience;Family;Fees;Food deprivation (experimental);Funding;Genetic;Genetic Determinism;genetic pedigree;Genetic Predisposition to Disease;Genetic study;Goals;Heavy Drinking;high intensity drinking;Inbreeding;Indiana;Individual;Intake;Logistics;Maintenance;medical schools;Modeling;molecular targeted therapies;Mus;Nature;neural circuit;Neurobiology;operation;Outcome;pharmacologic;Phenotype;Physiological;Positioning Attribute;pre-clinical;preference;Prevention;Problem Solving;Procedures;Production;Public Health;Qualifying;Rattus;Recording of previous events;Relapse;Research;Research Personnel;resilience;Resistance;Resources;Risk;Rodent;Running;Schools;Science;screening;Services;Substance abuse problem;substance use;Symptoms;Therapeutic;Time;Training;Universities;vapor;Wistar Rats;Work

PROJECT_TITLE: Animal Production Core


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Infectious Diseases;Mental Health;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Program Director/Principal Investigator: Kendler, Kenneth S Project Narrative – This project seeks to clarify etiologic pathways to aggregate drug abuse and opiate abuse more specifically. To accomplish this goal, we will utilize a unique and growing set of epidemiological resources available in the country of Sweden and a range of advanced statistical modeling methods. The resulting findings will be relevant to the US and other developed countries, with potential impacts on drug abuse prevention, treatment and policy.

PI_NAMEs: KENDLER, KENNETH SEEDMAN (contact);SUNDQUIST, JAN O

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Achievement;adverse childhood events;Affect;Age;Calibration;Characteristics;Clinical;college;Communicable Diseases;Communities;Community Services;comorbidity;Complex;contagion;Country;COVID-19;Data;Data Sources;Developed Countries;Development;Diagnosis;disorder risk;Divorce;Drug abuse;drug abuse prevention;Drug Evaluation;Drug Use Disorder;Environment;Environmental Risk Factor;epidemiological model;Epidemiology;Etiology;Family;Funding;gene environment interaction;Genetic;genetic epidemiology;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Geographic Information Systems;Geography;Goals;high risk;high school;Iatrogenesis;Imprisonment;improved;Individual;Influenza;information framework;Injury;innovation;Institution;Interpersonal Violence;Joints;Laboratories;Link;Low Back Pain;Marriage;Measles;men;Methods;military service;model development;Modeling;models and simulation;National Institute of Drug Abuse;Natural experiment;Nature;Neighborhoods;Onset of illness;opioid abuse;opioid use disorder;Pain;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacoepidemiology;Phase;Phenotype;Policies;Population;Post-Traumatic Stress Disorders;prescription opioid;Prevention;Principal Investigator;Productivity;programs;progression risk;protective effect;protective factors;psychiatric comorbidity;Public Health;Recurrence;Registries;Research;resilience;Resources;Risk;Role;Sampling;SARS-CoV-2 exposure;Schools;Severities;social;Social Distance;social epidemiology;social influence;Source;Spouses;Statistical Models;stress related disorder;Stressful Event;Students;Sweden;Syndrome;synthetic construct;synthetic data;tool;transmission process;traumatic event;Universities;Virginia;Woman;Work;Workplace

PROJECT_TITLE: Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE This research will provide critical new knowledge to our understanding of the receptors underlying neuromodulatory influences on circuits in primary visual cortex. In particular, this research will determine if there are differences in magnocellular vs parvocellular pathways in early processing by dopamine D2 or serotonin 5-HT2A receptors, and if center-surround mechanisms as a function of stimulus size, orientation, or contrast are modulated by D2 or 5-HT2A. The outcomes of this research will strengthen our understanding of neuromodulatory mechanisms in visual processing, and provide key insights into why some schizophrenic patients develop changes in early visual processing and see improvements with antipsychotic medications.

PI_NAMEs: GALVIN, VERONICA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affinity;Agonist;Anatomy;antagonist;Antipsychotic Agents;area striata;atypical antipsychotic;Autoradiography;Binding;Cells;Chemicals;Cholinergic Receptors;Clinical;Contrast Sensitivity;Data;density;Dependence;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;dopamine system;Drug Delivery Systems;Drug Prescriptions;Drug Targeting;Electrodes;Electrophysiology (science);Etiology;excitatory neuron;Exhibits;experimental study;extrastriate visual cortex;Family;Follow-Up Studies;Frequencies;Hallucinogens;HTR2A gene;improved;Individual;information processing;inhibitory neuron;insight;Iontophoresis;Knowledge;Lateral Geniculate Body;Literature;magnocellular;Measures;Mediating;Mental disorders;Messenger RNA;Motion;nerve supply;Nervous System Disorder;neural;Neuromodulator;Neurons;neuroregulation;Norepinephrine Receptors;Outcomes Research;parvocellular;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Primates;receptor;receptor expression;Reporting;Research;Resources;response;Retina;Role;Schizophrenia;Serotonergic System;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Transduction;Site;Source;Stimulus;symptomatic improvement;Symptoms;Testing;Thalamic structure;Time;Visual;visual information;Visual Pathways;visual processing

PROJECT_TITLE: Probing D2 and 5HT-2A mechanisms in early visual processing in V1


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Pediatric;Substance Misuse;Underage Drinking

PI_NAMEs: YODER, KARMEN K (contact)

PROJECT_TERMS: addiction;Address;Adolescent;Alcohol consumption;alcohol research;alcohol response;alcohol use disorder;Alcohols;Area;Basic Science;Catchment Area;Cessation of life;clinical practice;Clinical Research;Clinical Trials;Collaborations;collaborative environment;Data;Dentistry;Development;Discipline of Nursing;Doctor of Philosophy;drinking;Engineering;experience;Extramural Activities;Faculty;flexibility;Funding;Funding Mechanisms;Genetic Determinism;Goals;Grant;hazardous drinking;Human;Indiana;Informatics;Interruption;Learning;medical schools;meetings;Mentors;Methods;National Institute on Alcohol Abuse and Alcoholism;novel;novel strategies;Outcome;Participant;Pilot Projects;Policies;pre-clinical;premature;Preparation;Prevention strategy;Process;programs;Publications;Research;Research Personnel;Resources;Rodent Model;Schools;Science;Secure;success;Translating;treatment strategy;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot Core


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Of the approximately five million deaths in children younger than five years in 2018, half were attributable to infectious causes while malnutrition is the underlying contributing factor in nearly one half of all child deaths globally. The Ethiopia Infectious Disease Research Training Program, proposed by the Harvard T.H. Chan School of Public Health and Addis Continental Institute of Public Health, will harness scientific knowledge and skills to enhance prevention, treatment and control of pediatric infectious diseases causing major morbidity and mortality in Ethiopia and develop stronger capacity related to nutrition given its central role in the incidence and severity of infection. Through doctoral and postdoctoral fellowships, intensive short courses, and scientific symposia, this training program aims to train a critical mass of public health researchers to carry out successful research in pediatric infectious diseases and nutrition in Ethiopia.

PI_NAMEs: BERHANE, YEMANE ;FAWZI, WAFAIE W (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acute respiratory infection;Advisory Committees;Area;Award;Boston;Career Mobility;Charge;Child;Childhood;Clinical Trials;Collaborations;Communicable Diseases;Communities;Data Analyses;Development;diarrheal disease;Educational process of instructing;Educational Status;Epidemiologic Methods;epidemiology study;Equilibrium;Ethiopia;experience;Exposure to;Faculty;Fellowship;Funding;Goals;Health Personnel;Health Professional;Health Services;Institution;Instruction;Malnutrition;Manuscripts;Mentors;Morbidity - disease rate;mortality;nutrition;Nutritional Study;operation;Operations Research;Participant;Policy Maker;Postdoctoral Fellow;Prevention;Principal Investigator;programs;Public Health;Research;Research Design;Research Personnel;Research Proposals;Research Training;Series;skills;Structure;Students;symposium;Training;training opportunity;Training Programs;Universities;Work

PROJECT_TITLE: Ethiopia Global Infectious Diseases Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The CNBD family of ion channels control the electrical excitability in the brain and the heart, and defects in these channels cause many human disorders. Our long-term goal is to understand how these channels work at the molecular level so that we can better understand their role in the physiology of the brain and heart.

PI_NAMEs: ZAGOTTA, WILLIAM N (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Allosteric Regulation;Binding;Biology;Brain;Cell membrane;Cells;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Data;Defect;Dependence;Disease;experimental study;Family;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fluorometry;Four-dimensional;Goals;Heart;Human;Ion Channel;Ions;Ligands;Maps;Measures;member;Methods;Molecular;Molecular Conformation;Molecular Machines;Molecular Structure;Neurotransmitters;patch clamp;Physiology;Proteins;Resolution;response;Role;Second Messenger Systems;Site;small molecule;Stimulus;Time;voltage;Work

PROJECT_TITLE: Structural energetics of voltage- and ligand-dependent gating in ion channels


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE  Autism spectrum disorder is associated with language delays in young children. We seek to understand the condi- tions underlying successful language learning in order to inform innovative interventions that are most likely to promote language skills in this population.

PI_NAMEs: ARUNACHALAM, SUDHA  (contact);LUYSTER, RHIANNON JANET

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 5 year old;Address;Adult;Age;autism spectrum disorder;autistic children;Behavior;Characteristics;Child;Clinical Research;Control Groups;Development;Education;Educational process of instructing;experimental study;Hour;individuals with autism spectrum disorder;innovation;Instruction;Intervention;Investigation;joint attention;Knowledge;Label;Language;Language Delays;Language Development;Language Disorders;language impairment;Learning;Linguistics;Link;Measures;non-verbal;novel;Nursery Schools;Outcome;outcome prediction;Pattern;Performance;Play;Population;pressure;Procedures;Productivity;Research;Role;Sampling;Severities;skills;social;social communication;social communication impairment;Social Interaction;social skills;success;successful intervention;Testing;therapy design;Videoconferencing;visual tracking;Vocabulary;word learning;Work

PROJECT_TITLE: Learning new words from overhearing in children with ASD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

PI_NAMEs: CYDERS, MELISSA A (contact)

PROJECT_TERMS: addiction;adolescent substance use;Advocacy;alcohol availability;alcohol behavior;Alcohol consumption;alcohol research;alcohol response;alcohol use disorder;Alcohols;Awareness;Behavior;Caring;Client;Collaborations;Communities;community based participatory research;Community Health Education;community organizations;community partners;community partnership;Development;Disease;disorder prevention;drinking behavior;Education;Educational Materials;evidence base;Family member;Funding;Genetic Determinism;Goals;health disparity;Health Personnel;Healthcare;high intensity drinking;Hospitals;improved;improved outcome;Indiana;Information Dissemination;Institution;Intervention;Knowledge;Legal;Mental Health;Outcome;outreach;Patients;Policies;Prevalence;Prevention;Prevention program;Process;Professional counselor;programs;Provider;Research;research data dissemination;Research Personnel;Resources;Risk;Risk Factors;school district;School Nursing;Schools;Science;Services;substance use;substance use prevention;teacher;Training;Training Programs;treatment center;underage drinking;underserved community;Underserved Population;web site;Work;Youth

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A crucial component of healthy and expressive vocalization is a fundamental frequency (pitch) range that can provide ample prosody in speech and melodic range in singing. Humans and non-human mammals and birds exhibit considerable variety in vocal fold design to accommodate pitch ranges necessary for survival and social interactions. Here we explore the properties of the vocal ligament, a layer of vocal fold tissue often referred to as the vocal ”cord”, which we will show to be responsible for an extended pitch range and stability in vocalization.

PI_NAMEs: TITZE, INGO R (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: The Role of the Vocal Ligament in Vocalization


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The ability to target challenging intracellular proteins and protein-protein interactions – "drugging the undruggable" – is a primary challenge in medicinal chemistry today. Membrane permeable macrocyclic peptides (MCPs) inspired by natural products offer a new paradigm for tackling these difficult targets. The proposed program will continue nearly two decades of basic science pioneered in my lab toward understanding and predicting the drug-like properties of MCPs, with the ultimate goal of developing a general platform for lead discovery against undruggable intracellular targets.

PI_NAMEs: LOKEY, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: absorption;Address;analytical tool;Antibodies;Basic Science;Behavior;Cell Membrane Permeability;Cells;Chemicals;Chromatography;Development;DNA;Drug Kinetics;Geometry;Goals;inhibitor;Lead;Libraries;lipophilicity;liver metabolism;Medicine;member;Membrane;Metabolism;Natural Products;Nature;next generation sequencing;novel;Oral;Peptides;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Positioning Attribute;programs;Property;protein protein interaction;Proteins;Research;scaffold;Side;Specificity;Technology;Vertebral column

PROJECT_TITLE: Advancing the basic science of membrane permeability in macrocyclic peptides


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Mutations in the mTOR pathway gene KPTN are associated with an enlarged brain, autism spectrum disorder, intellectual disability, and epilepsy. This application will investigate both in vitro and in vivo models of KPTN loss to study the effects of KPTN on brain development and develop an approach for a clinical trial to treat patients with KPTN loss.

PI_NAMEs: CRINO, PETER B (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 19q13.32;Abnormal Cell;Adult;Affect;Age;AKT3 gene;Amaze;Amino Acids;Amish;autism spectrum disorder;autosome;Biological Assay;Biological Models;Birth;Brain;Brain imaging;brain overgrowth;brain size;Caring;cell motility;Cell Proliferation;Cell Size;Cellular Morphology;Child;Clinic;Clinical;clinical center;Clinical Data;Clinical Trials;cohort;Collaborations;college;Communities;Complex;CRISPR/Cas technology;Data;Databases;Dedications;Development;Developmental Delay Disorders;Diagnostic;Electroencephalography;Enrollment;Epilepsy;epileptiform;Exhibits;Family;FRAP1 gene;General Population;Genes;Genome;Genotype;Germ-Line Mutation;global developmental delay;Growth;Head circumference;hemimegalencephaly;Histopathology;Hospitals;Human;In Vitro;in vivo;in vivo Model;Individual;infancy;inhibitor;Intellectual functioning disability;International;Intervention;Investigation;Laboratories;Life;Link;loss of function;Magnetic Resonance Imaging;Measurement;Medical;Medicine;Megalencephaly;Modeling;Motility;mouse model;Mouse Strains;mTOR inhibition;Mus;Muscle hypotonia;Mutation;nerve stem cell;neuroimaging;Neurologic;Neurons;neuropathology;Neuropsychological Tests;non-verbal;Ohio;Operative Surgical Procedures;Parents;Pathogenicity;Pathway interactions;Patients;Pennsylvania;Phenotype;Plant Leaves;Play;Polyhydramnios, megalencephaly, and symptomatic epilepsy;Population;postnatal;prevent;Proliferating;prospective;protein complex;PTEN gene;Refractory;Registries;Research;response;Role;Running;Seizures;Signal Transduction;Sirolimus;Specialist;Syndrome;therapeutic target;Thick;Variant

PROJECT_TITLE: KPTN Loss and Megalencephaly: mTOR Activation as Therapeutic Target

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: LAPISH, CHRISTOPHER COURT (contact)

PROJECT_TERMS: addiction;Alcohol consumption;alcohol research;alcohol response;alcohol use disorder;Alcohols;Area;ARHGEF5 gene;Articulation;Artificial Intelligence;Behavioral;Biophysics;Brain;Complement;Computer Models;Data;Data Analyses;Data Set;dynamic system;Electrophysiology (science);experience;Functional Magnetic Resonance Imaging;Genetic Determinism;Goals;Heritability;high intensity drinking;Human;Impairment;Indiana;insight;Lead;Link;Measures;Modeling;multidimensional data;NCAM1 gene;Network-based;neural;neural circuit;Neurobiology;Neurophysiology - biologic function;novel;novel strategies;Pathology;Pathway Analysis;Population;Population Analysis;Predisposition;Prosencephalon;Research;Risk;Rodent;Services;Signal Transduction;Source;Statistical Data Interpretation;synergism;System;Techniques;Testing;translational potential;Translations;virtual;Work

PROJECT_TITLE: Network Analysis and Computational Modeling Core


NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_NAME: NEW YORK BLOOD CENTER

PHR: Project Narrative The studies proposed in this application focuses on a subset of white blood cells, called monocytes in patients with sickle cell disease and how they participate in the control of the immune response to transfusions and disease complications including pain crisis. Knowledge gained from these studies will help identify immune signatures of patients most likely to benefit from tailored selection of blood products for transfusions and aid in the development of new therapies to treat key sickle cell disease complications including pain crisis.

PI_NAMEs: YAZDANBAKHSH, KARINA  (contact)

PROJECT_TERMS: Affect;Alloimmunization;Area;Biological Models;blood product;cell type;Cells;Chronic;Clinical;Development;Disease;Drug Metabolic Detoxication;Endothelium;Enzymes;Event;Experimental Models;Functional disorder;Goals;Heme;heme oxygenase-1;Hemolysis;human model;Immune;Immune response;In Vitro;in vivo;Inflammatory;Innate Immune Response;interest;Isoantibodies;Knowledge;Laboratories;Leukocytes;Life;Mission;Molecular;monocyte;mouse model;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Pain;Pathway interactions;patient population;Patients;prevent;programs;protective pathway;Reaction;Research;Role;Sampling;Sickle Cell;Sickle Cell Anemia;therapeutic target;Transfusion

PROJECT_TITLE: Immune Pathophysiology of Sickle Cell Disease


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This program will establish the IMSD@Brown T32 Program as the institutional Integration Hub for broadening graduate diversity across multiple STEM Ph.D. programs to create a critical mass of outstanding and diverse research scientists, scholars and educators. IMSD@Brown will: a) develop the academic, co-curricular scaffolds around participating trainees, b) build an institutional culture of increased diversity and inclusion across all STEM disciplines, c) support interdisciplinary training and d) strengthen mentoring, advising and professional development practices across all programs. IMSD@Brown will drive and sustain improvements in compositional diversity, in institutional climate, and in culture change by preparing scholars skilled and equipped to join the U.S. scientific biomedical workforce to advance human health and knowledge, and track progress using formative and summative evaluations.

PI_NAMEs: DE GRAFFENRIED, CHRISTOPHER LUIS;DELANEY, SARAH ;HARRINGTON, ELIZABETH O (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: PLAWECKI, MARTIN H. (contact)

PROJECT_TERMS: Acute;Affect;Alcohol consumption;alcohol effect;alcohol related problem;alcohol research;alcohol response;alcohol use disorder;Alcoholism;Alcohols;Animal Model;Anterior;Area;Attention;Behavior;Behavior Control;binge drinking;Biological;Blood alcohol level measurement;Brain;cingulate cortex;Closure by clamp;cognitive control;Consumption;Corpus striatum structure;Dangerousness;Data;density;Dorsal;drinking;Electrophysiology (science);experience;Family history of;Genetic;Genetic Determinism;Genetic Risk;Goals;Health;Heritability;high intensity drinking;high risk drinking;Hour;improved;Impulsivity;Indiana;Insula of Reil;Intake;Intervention;Intravenous;Investigation;Laboratories;Life;Measures;men;mental state;Modeling;Motivation;negative affect;neural circuit;Neurobiology;neuroimaging;neuroregulation;novel;Participant;Pattern;Persons;Phenotype;Pre-Clinical Model;Prevention;rate of change;Recording of previous events;Reproducibility;Research;response;Rest;reward circuitry;Rewards;Risk;risk variant;Self Administration;Sensory;sex;Signal Transduction;Speed;success;Sucrose;sweet taste perception;Techniques;Time;translational study;Ventral Striatum;Woman;Work

PROJECT_TITLE: Binge & High-Intensity Drinking: Rate, Acute Tolerance, and Salience


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Epigenetic alterations including heterochromatin changes are important for cancer development as well as tumor suppression, but the mechanisms remain unclear. The current project focuses on a novel suppressor of Ras, CRIF, which may provide an inroad leading to understanding how oncogenic Ras reorganizes chromatin to induce cell proliferation and how heterochromatin formation functions in epigenetic tumor suppression. Understanding how CRIF regulates heterochromatin and counteracts oncogenic signals to resist tumorigenesis may lead to novel epigenetic cancer therapeutics.

PI_NAMEs: LI, WILLIS X (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Attention;Binding;Binding Sites;Biogenesis;Cell Aging;Cell Proliferation;Chromatin;chromatin modification;Chromatin Structure;Development;Drosophila genus;Epigenetic Process;epigenetic regulation;Event;fly;Future;Gene Expression;Gene Expression Regulation;Gene Silencing;Genetic;Genetic Transcription;Genomic DNA;Genomics;Goals;Growth;Heterochromatin;Histone H3;histone methyltransferase;histone modification;Histones;Homologous Gene;Human;Hypermethylation;Inhibition of Cell Proliferation;Investigation;Knowledge;Lysine;Malignant Neoplasms;Mediating;Methods;Methylation;Mitosis;Molecular;Mutation;novel;Oncogenic;Oncoproteins;Organ;Organ Size;Organism;Output;overexpression;Pathway interactions;Play;Proliferating;Proteins;RAS inhibition;recruit;Regulation;Reporting;Research;Resistance;response;restraint;RNA Interference;Role;Sequence Homology;Signal Transduction;Small RNA;System;Therapeutic;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA

PROJECT_TITLE: Functions of a novel suppressor of oncogenic Ras


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: 8. PROJECT NARRATIVE Regulated cellular protein production, which plays a critical role in numerous biological processes vital for human health (such as normal cell growth, development, learning, memory and proper response to environ- mental stress) is disrupted in many human diseases, including cancer, diabetes, and viral infections, resulting in significant alterations in protein accumulation. Our studies use human cytomegalovirus (HCMV) as a power- ful model to investigate the complex cellular circuitry that properly regulates protein production. A comprehensive picture of how protein production is controlled could contribute to new strategies of treating many human diseases including those caused by HCMV, which despite being innocuous in most healthy individuals causes severe disease in those whose immune systems are not functioning properly (including transplant recipients along with AIDS patients) and is the leading viral cause of birth defects in newborns.

PI_NAMEs: MOHR, IAN J (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Attenuated;Binding;biological adaptation to stress;Biological Models;Biological Process;Biology;Bone Marrow;Bypass;cell growth;Cells;Chronic;Complex;Congenital Abnormality;Cytomegalovirus;Cytomegalovirus Infections;Data;design;Development;Diabetes Mellitus;Disease;endoplasmic reticulum stress;Environment;Family member;Fostering;FRAP1 gene;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Health;Herpesviridae;Human;human disease;Immune response;Immune system;Immunocompromised Host;Individual;Infection;insight;Investigation;Knowledge;Learning;Malignant Neoplasms;Memory;Messenger RNA;Modeling;Molecular;mRNA Translation;mutant;Newborn Infant;Normal Cell;opportunistic pathogen;organ transplant recipient;Organism;Patients;Peptide Initiation Factors;Phosphorylation;Physiological;Play;polyadenylated messenger RNA;Polyribosomes;Production;Protein Biosynthesis;Proteins;recruit;Regulation;Reproduction;response;Ribosomes;RNA Cap-Binding Proteins;Role;Shapes;Solid;Stress;Testing;Therapeutic;Therapeutic Intervention;Translation Initiation;Translations;Transplant Recipients;vaccine development;vaccine strategy;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Control of Translation in Herpesvirus Infected Cells - Resubmission - 1

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]