NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: Project Narrative: Community Engagement Core The METALS SRP Community Engagement Core links Native American community members exposed to hazardous substances in uranium mine wastes to the METALS environmental and biomedical projects that aim to reduce exposures through innovative remediation methods, biospecimen collections and biomonitoring to ascertain exposures, and community participation in ongoing federal and tribal Superfund remedial action decisions. CEC seeks to reduce health risks of exposures to mixed-metal mining wastes in other parts of the Western U.S. by sponsoring webinars in Indigenous Science that will emphasize for the national SRP network a place-based, participatory approach to the vexing and widespread problem of cleaning up large-volume metal-laden wastes.

PI_NAMEs: SHUEY, CHRISTOPHER L (contact)

PROJECT_TERMS: Address;Affect;Agriculture;Air;Airborne Particulate Matter;Area;Arsenic;authority;Back;Biological Monitoring;Biological Sciences;Biomedical Research;Certification;citizen science;Clinical;Clinical Trials;Collaborations;Collection;Communities;community empowerment;community engagement;Community Health;community involvement;Community Participation;community partners;Consent;Consumption;Custom;Data;Decision Making;design;Development;DNA Repair;Dust;Education;Educational workshop;empowerment;Environmental Science;experience;exposed human population;exposure pathway;Exposure to;Farm;farmer;Food;Food Supply;forging;Formulation;Funding;fungus;Goals;hazard;Hazardous Substances;Health;health data;Health Surveys;Human;Immune;Impairment;Indigenous;Information Centers;Infrastructure;Ingestion;Inhalation;innovation;International;Intervention;Knowledge;land use;Language;Laws;Link;Lung;Malignant Neoplasms;Measures;Medial;member;Metal exposure;metal poisoning;Metals;Methods;Mining;Modeling;Monitor;National Institute of Environmental Health Sciences;Native American community;Navajo;next generation;Online Systems;Participant;participant enrollment;particle;Particulate Matter;Pathway interactions;Pattern;Phase;Plants;Play;Policies;Prevention strategy;Process;programs;Pueblo Race;Radioisotopes;Recording of previous events;recruit;Regulation;remediation;Research;Research Personnel;Research Project Grants;Resources;respiratory;respiratory health;restoration;Risk;Risk Reduction;Role;Safety;Science;Scientist;Signal Recognition Particle;Site;Soil;Source;Stream;Students;submicron;Superfund;synergism;Systemic disease;Thinking;Toxic effect;Trace metal;Training;Translational Research;tribal lands;Tribes;uptake;Uranium;Vanadium;virtual;wasting;Water;water quality;weather stations;webinar;Work;Zinc

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative – Data Management and Analysis Core (DMAC) The Data Management and Analysis Core (DMAC) has direct public health relevance as it will provide analysis support for the UNM METALS research projects, and perform comprehensive assessments of environmental exposure profiles to search for disease risk factors. The DMAC will also develop integrative modeling of the environmental and biological research data to detect unique exposure profiles for risk classification and disease prevention. It will also provide valid data and scientific conclusions that can be translated to inform intervention strategies with the ultimate goal to improve community health.

PI_NAMEs: LUO, LI  (contact)

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Air;Autoimmune Diseases;Basic Science;Bayesian Method;Behavior;Biological Markers;biological research;Biometry;Biostatistical Methods;Characteristics;Chemicals;Chronic;Classification;Collaborations;Communities;community engagement;Community Health;Complex;Complex Analysis;Contracts;Data;Data Analyses;Data Analytics;Data Collection;data integration;data interoperability;data management;data quality;data repository;data reuse;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;Diabetes Mellitus;Disease;disorder prevention;disorder risk;diverse data;Documentation;Education;Educational workshop;Elements;Ensure;Environmental Exposure;Environmental Health;environmental health disparity;Etiology;experience;Exposure to;Faculty;FAIR principles;Food;Fostering;Generations;Goals;gut microbiome;Health;Health Disparities Research;high dimensionality;Hypertension;Immune;Immune response;improved;Infrastructure;Ingestion;Inhalation;innovation;interactive visualization;Interdisciplinary Study;Intervention;Joints;Kidney Diseases;large datasets;lectures;Life Style;Link;Machine Learning;Manuscripts;Mediating;member;Metadata;metal complex;Metal exposure;metal poisoning;Metals;Methodology;Methods;microbiome;Modeling;Modernization;Monitor;multidisciplinary;Native American community;Navajo;novel;Outcome;Participant;Pathway interactions;Phase;population health;Population Study;Positioning Attribute;Practice Management;Prevention strategy;Process;Productivity;programs;Protocols documentation;Psychosocial Stress;public health relevance;quality assurance;Quality Control;Regulation;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Risk;Risk Factors;Role;Safety;Sample Size;Scientist;Security;Socioeconomic Status;sound;Source;Standardization;Statistical Data Interpretation;Statistical Methods;Statistical Models;Superfund;System;Techniques;tool;Toxic effect;Toxicant exposure;Training;Training Activity;Translating;Translational Research;tribal lands;Uranium;wasting;Water;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative / Lay Language Description Pathogens that cause diarrheal disease account for an immense global public health burden, primarily among young children in low-resource settings. The use of antibodies to study the epidemiology of diarrhea-causing pathogens has potential to improve our measurement of pathogen transmission in research and surveillance. This project will advance the epidemiologic methods used to measure diarrhea-causing pathogen exposure at the population level, by completing the first comprehensive study that pairs antibody-based and stool-based measures of infection among a birth cohort living across a rural-urban gradient in Ecuador.

PI_NAMEs: ARNOLD, BENJAMIN F (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 2019-nCoV;Address;Age;Antibodies;antibody detection;Antibody Response;Antigens;Arboviruses;Benchmarking;Biological Assay;Birth;Blood;Blood Tests;burden of illness;Campylobacter jejuni;Characteristics;Child;Clinical;cognitive development;cohort;Complement;Cross Infection;Cross-Sectional Studies;Cryptosporidium parvum;Data;demographics;Dengue;design;Diarrhea;diarrheal disease;Disease;Ecuador;Enrollment;Entamoeba histolytica;Enteral;enteric infection;enteric pathogen;enterotoxigenic Escherichia coli;Environment;Epidemiologic Methods;Epidemiology;epidemiology study;Failure;Feces;Frequencies;Funding;Giardia;Goals;Growth;gut microbiome;Heterogeneity;HIV;Immunoglobulin A;Immunoglobulin G;improved;Incidence;Infant Mortality;Infection;insight;Kinetics;Language;Legal patent;Longitudinal cohort;Longitudinal Studies;Machine Learning;Malaria;Measurement;Measures;Methods;Modeling;Molecular;Monitor;multiplex assay;National Institute of Allergy and Infectious Disease;Nature;Newborn Infant;Norovirus;pathogen;pathogen exposure;Population;population based;Population Density;Public Health;public health intervention;Recording of previous events;Research;Resolution;Resource-limited setting;response;Rural;Salmonella enterica;Sampling;Series;Serology;serosurveillance;serosurvey;Serum;Site;Source;Specimen;stool sample;Surveys;Testing;Time;tool;transmission process;urban area;Urbanization;Variant;Visit

PROJECT_TITLE: Enteric Pathogen Force of Infection among Children using Serology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PHR: NARRATIVE The Research Experience and Training Coordination Core (RETCC) of the UNM METALS Center has been established to coordinate graduate and postdoctoral level cross-disciplinary research experiences and training in fields related to biomedical research and environmental science and engineering research. The RETCC is designed to address gaps in the interdisciplinary training experiences of the various academic departments at UNM to give our trainees broader perspectives of their work in the context of our regional environmental health issues.

PI_NAMEs: CAMPEN, MATTHEW J (contact)

PROJECT_TERMS: Address;base;Biological Sciences;Biomedical Research;career;career development;Communication;Communities;community engagement;Cultural Sensitivity;curriculum development;design;Development;Development Plans;Discipline;Discipline of Nursing;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Ensure;Environmental Engineering technology;Environmental Health;Environmental Science;Evaluation;experience;Faculty;Feedback;Future;global environment;Health;Health Sciences;Indigenous;indigenous community;innovation;Institution;Interdisciplinary Study;International;Journals;Knowledge;laboratory experience;Leadership;Learning;Link;medical schools;meetings;member;Mentors;Metal exposure;metal poisoning;Metals;Minority;Modality;Modeling;Native American community;Native Americans;next generation;Oral;Pharmacy facility;Phase;physical science;Play;population health;Postdoctoral Fellow;Process;programs;Qualifying;Reporting;Research;Research Personnel;Research Training;Resources;Role;science education;science teacher;Scientific Advances and Accomplishments;Series;skill acquisition;Superfund;symposium;timeline;tool development;Training;Travel;tribal community;tribal lands;undergraduate student;Underrepresented Minority;Work;Writing


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Catalytic fragment-based C‒C coupling reactions enable the preparation and diversification of candidate pharmaceutical compounds that help prevent and treat disease. The proposed research will improve synthetic methods to prepare and diversify pharmaceutical compounds by accessing new reaction paradigms, i.e., the interfacial design of electrocatalysts, to selectively introduce C(sp3)–C(sp3) bonds.

PI_NAMEs: WUTTIG, ANNA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Exploiting Interfacial Design for the Electrocatalytic Construction of C-C bonds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Health Services;Human Genome;Pain Research;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to public health because it focuses on ethical and social implications of medical genomics for patients with rare diseases. Using in-depth, mix-methods research, this work will develop concrete, pragmatic communication strategies that can improve care for patients with rare genetic disorders. Therefore, the project is relevant to NHGRI’s mission because it pertains to analyzing the impact of genomics on society.

PI_NAMEs: HALVERSON, COLIN MICHAEL EGENBERGER (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Academy;Address;Affect;Anthropology;Area;Automobile Driving;Award;career;Caring;Clinical;clinical diagnosis;clinical encounter;cohort;Communication;Communication Research;Complex;Coupled;Dangerousness;Data;Data Analyses;design;Diagnosis;Diagnostic;Disabling;Disease;distrust;Ehlers-Danlos Syndrome;Emotional;ethical, legal, and social implication;Ethics;Event;experience;Face;Failure;Feeling;Foundations;Funding;Genes;Genetic;Genetic Research;Genomic medicine;Genomics;Goals;Health;Healthcare;Hereditary Disease;Impairment;improved;Indiana;innovation;insight;Intervention;Intervention Studies;Interview;Judgment;Legitimacy;Measures;Medical;Medical Genetics;Medical Research;medical schools;medical specialist;Mentored Research Scientist Development Award;Methods;Mission;Molecular;Molecular Diagnosis;Musculoskeletal Pain;National Human Genome Research Institute;Outcome;Pain intensity;pain patient;pain reduction;Patient Care;patient population;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;Patients;Perception;persistent symptom;Play;Population;Positioning Attribute;Primary Care;programs;Provider;psychologic;Public Health;Quality of Care;Rare Diseases;rare genetic disorder;Registries;Reporting;Research;Research Ethics;Research Methodology;Research Personnel;Rheumatology;Role;Scientist;Site;skills;social;social implication;Societies;sound;Surveys;Testing;Training;Universities;Validation;Work;working group

PROJECT_TITLE: Improving Care for Rare Genetic Diseases: Patient-Provider Communication and Patient Validation in the Ehlers-Danlos Syndromes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SEIR-E(80)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: TOLEDO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Drug resistance and minimal residual disease in triple-negative breast cancer (TNBC) leads to aggressive tumors and metastasis leading to many fatalities. Altered tumor protein profile in TNBC contributes to therapy resistance in the clinic. The proposal outlines a strategy to identify the mechanisms through which eIF4A1 might facilitate drug resistance program in TNBC Finally, we outline strategies to overcome chemoresistance by co-targeting eIF4A1 and its downstream translational targets in breast cancer stem-like cells (BCSCs) and bulk tumor cells in metastatic TNBC.

PI_NAMEs: RAMAN, DAYANIDHI  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 4T1;ABCB1 gene;ABCC1 gene;ABCG2 gene;Adjuvant Chemotherapy;aldehyde dehydrogenases;Allografting;Anthracycline;Apoptosis;ATP-Binding Cassette Transporters;Breast Cancer Cell;Breast Cancer Patient;CD44 gene;Cell Survival;Cells;Chemoresistance;Clinic;Clinical;Combined Modality Therapy;Cyclin D1;cyclin D3;Data;Disease;Distant Metastasis;Drug resistance;Drug Targeting;efficacy evaluation;Eukaryotic Initiation Factors;Fractionation;Goals;helicase;Human;Immune Evasion;immunodeficiency;immunoregulation;Immunotherapy;improved;In complete remission;in silico;In Vitro;in vivo;insight;Invaded;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;MCL1 gene;Mediating;Messenger RNA;Modeling;Molecular;mortality;mouse model;Mus;mutant;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenic;Outcome;Pathologic;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;phase I trial;Platinum;pluripotency;Poly(ADP-ribose) Polymerase Inhibitor;Polyribosomes;Population;pre-clinical;programs;Proliferating;Property;Protein Biosynthesis;Proteins;Regulation;Relapse;Residual Neoplasm;Resistance;Rho-associated kinase;Role;self-renewal;stem-like cell;stemness;Structure;Survival Rate;survivin;targeted treatment;taxane;Tetanus Helper Peptide;therapy resistant;Tissue Microarray;transcription factor;Translating;Treatment Failure;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor initiation;tumorigenesis;Up-Regulation

PROJECT_TITLE: Targeting eIF4A1 in drug-resistant breast cancer stem-like cells

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sleep Research;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Increasing physical activity and sleep during pregnancy may help mitigate risk for adverse pregnancy outcomes in overweight and obese pregnant women. How the interdependent relationships between physical activity, sedentary behavior, and sleep within a 24-hour movement framework during pregnancy affect risk for altered maternal metabolic profile and subsequent childhood obesity risk in infants remains unclear. This project will guide development of clinical and public health recommendations and interventions for 24-hour movement during pregnancy by studying the impact of 24-hour movement profiles on maternal metabolic profile and childhood obesity risk factors.

PI_NAMEs: BADON, SYLVIA E (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accelerometer;adiponectin;adverse pregnancy outcome;Affect;aged;Award;Behavior;Biological Markers;Birth Weight;cardiometabolic risk;Child;clinical development;cohort;critical period;Data;Data Analyses;Data Collection;Development;Devices;diabetes risk;early detection biomarkers;early pregnancy;Epidemiology;Exposure to;Funding;General Population;Gestational Age;Gestational Diabetes;Glucose;glucose tolerance;Goals;Growth;Guidelines;Health;high risk population;Hour;improved;in utero;Individual;Infant;innovation;Insulin;Insulin Resistance;Intervention;Investigation;Late pregnancy;Leptin;Lipids;maternal obesity;Measurement;Measures;Mentors;Mentorship;Metabolic;metabolic profile;Movement;Nature;newborn adiposity;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overnutrition;Overweight;Pathway interactions;Pattern;Perinatal;perinatal outcomes;Phase;Physical activity;Physiology;Polysomnography;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal exposure;prevent;Public Health;Recommendation;recruit;reproductive;Research;Research Activity;Research Personnel;research study;Risk;Risk Factors;risk mitigation;Role;sedentary lifestyle;skills;Sleep;sleep behavior;sleep physiology;Time;Training;Training Activity;United States;vigorous intensity;Weight;Woman;Work

PROJECT_TITLE: Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Precision Medicine;Prevention

ORG_CITY: CHARLESTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Olfactory dysfunction (OD) occurs in the majority of elderly adults and is often unrecognized. It has been shown to have significant impacts upon patient health and mortality, thus improved understanding of how OD occurs in individual subjects and its progression is sorely needed. Future treatments to prevent or reverse OD in aging adults will depend upon improved understanding of mechanisms by which it occurs and its impact upon patient health.

PI_NAMEs: SCHLOSSER, RODNEY JON (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adult;Affect;Age;Age Years;Aging;analog;Anatomy;Anosmia;Area;Biological Markers;Body Weight Changes;central gray matter;Characteristics;Classification;Clinical;clinical phenotype;clinically relevant;Cognition;cognitive function;cognitive testing;comorbidity;cooking;cribriform plate;Data;Demographic Factors;demographics;Desire for food;Diagnostic;diagnostic development;Dimensions;Disease;Elderly;Elements;Endoscopy;Enrollment;Food;Functional disorder;Funding;Future;Health;Health Surveys;hearing impairment;Hygiene;Impairment;improved;Individual;insight;interest;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;Mental Depression;Methodology;Methods;Modeling;Moods;mortality;Mucous body substance;Nasal cavity;National Institute on Deafness and Other Communication Disorders;Natural History;neuroepithelium;nutrition;older adult;Older Population;Olfactory dysfunction;Olfactory Nerve;Olfactory Pathways;olfactory receptor;Outcome Measure;Pathology;Patient Outcomes Assessments;Patients;Peripheral;personalized medicine;Persons;Phenotype;Population;population health;Predictive Factor;prevent;Prognostic Factor;prospective;Prospective, cohort study;Proteins;Protocols documentation;Psychophysics;psychosocial;Quality of life;Radiology Specialty;Reporting;Research;Research Design;Safety;screening;sex;Site;Smell Perception;Social Interaction;Social isolation;specific biomarkers;Strategic Planning;Structure;Techniques;Testing;Therapeutic;Time;Variant;Visual;white matter

PROJECT_TITLE: Olfactory Dysfunction in Aging Adults

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE COVID-19 vaccines have been inequitably distributed and uptake has lagged especially in underserved communities necessitating culturally relevant and linguistically appropriate, dynamic, and scalable strategies for immediate and long-term success of COVID-19 vaccine uptake and pandemic mitigation. Addressing COVID-19 vaccine uptake behaviors offers an opportunity to concurrently improve engagement in other preventive health behaviors that are important public health priorities (e.g., diabetes management, cancer screenings, recommended adult vaccines). We propose to co-refine, test, and scale a multicomponent health program to address the multi-level barriers to vaccine uptake and engagement in primary and secondary preventative healthcare in immigrant, refugee, Latino, and Black, Indigenous People of Color (BIPOC) communities in San Diego.

PI_NAMEs: RABIN, ADRIENN BORSIKA ;STADNICK, NICOLE A (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Action Research;Address;Adoption;Adult;Appointment;Appointments and Schedules;Behavior;Black, Indigenous, People of Color;Border Community;care coordination;care outcomes;Clinic;colorectal cancer screening;Combined Vaccines;Communicable Diseases;Communities;community engagement;Community Healthcare;community partners;community-centered;Complex;Country;COVID-19;COVID-19 disparity;COVID-19 testing;COVID-19 vaccination;COVID-19 vaccine;Data;diabetes management;Disparity;driving force;Effectiveness;effectiveness outcome;Elements;enhanced care;Ethnic Origin;Evaluation;experience;FDA approved;Federally Qualified Health Center;Goals;Health;Health behavior;health care availability;health communication;health disparity;health equity;health literacy;Healthy People 2020;Hybrids;Immigrant;Immunization;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation/effectiveness;improved;Individual;Inequity;Influenza vaccination;innovation;Institution;Knowledge;Latino;Learning;Linguistics;long-standing disparities;low and middle-income countries;Low income;Maintenance;Mammography;Methods;Mexico;mHealth;mobile computing;Morbidity - disease rate;mortality;outreach;pandemic response;Persons;post implementation;Practical Robust Implementation and Sustainability Model;prevent;Preventive;Preventive care;Preventive healthcare;Process;programs;Public Health;public health priorities;RADx Underserved Populations;Recommendation;Refugees;Reporting;Research Personnel;Resources;SARS-CoV-2 infection;Schedule;Scientist;screening;Screening for cancer;Sequential Multiple Assignment Randomized Trial;Services;Social Change;social health determinants;success;Surveys;Technology;Testing;Text;Text Messaging;Thinking;trial design;Trust;underserved community;uptake;Vaccination;vaccine acceptance;vaccine distribution;vaccine hesitancy;Vaccines;Voice;Work

PROJECT_TITLE: Scaling and Sustaining COVID-19 Vaccination through Meaningful Community Engagement and Care Coordination for Underserved Communities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Bacterial ligand-induced murine vasculitis, coronary arteritis and myocarditis is highly dependent of NLRP3 inflammasome activation and bioactive IL-1β release. Here, we will characterize the immune cells infiltrating the inflamed tissues and investigate how the modulation of Sirtuin-1 activity could prevent the vascular innate immune responses leading to vascular inflammation and injury. We will also decipher the immune mechanisms by which Sirtuin-1 may lessen the inflammatory response by blocking the NLRP3 inflammasome response and the autophagy/mitophagy axis.

PI_NAMEs: NOVAL RIVAS, MAGALI  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acute;Adult;anakinra;antagonist;Antigen-Antibody Complex;Atherosclerosis;Autophagocytosis;Bacteria;Blood Vessels;cardioprotection;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Case Study;Cell Wall;Cells;Child;Childhood;Chronic;Clinical Trials;Coronary;Coronary Aneurysm;coronary arteritis;coronary fibrosis;Data;Deacetylase;Development;Disease;Etiology;experimental study;Fever;gene discovery;Gene Expression;Genetic;HDAC4 gene;Heart;Heart Diseases;high risk;Histologic;Human;IL1R1 gene;Immune;immune cell infiltrate;Immune response;Immunoglobulin G;Immunologics;Impairment;improved;In Vitro;Incidence;infection risk;Infectious Agent;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory Response;Innate Immune Response;insight;Interleukin-1;Interleukin-1 beta;Intravenous Immunoglobulins;Lactobacillus casei;Lesion;Ligands;Mediating;mitochondrial autophagy;Modeling;Molecular;Molecular Mimicry;Monoclonal Antibodies;mouse model;Mucocutaneous Lymph Node Syndrome;Mus;Myocardial Infarction;Myocardial Ischemia;Myocarditis;novel;novel therapeutics;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Play;Prediction of Response to Therapy;prevent;Prevention;Process;Production;protective effect;Recycling;Resistance;response;Risk;Role;Signal Transduction;SIRT1 gene;stem;Superantigens;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Tissues;transcriptome;translational potential;vascular inflammation;vascular injury;Vascular remodeling;Vasculitis;Whole Blood

PROJECT_TITLE: Targeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed work is relevant to public health and to the mission of the NICHD to improve child and adolescent health, and reduce disparities in care. Although most children receive emergency care in general emergency departments (EDs), national studies have shown that pediatric preparedness is low. Presence of a pediatric emergency care coordinator (PECC) is associated with increased preparedness, but limited data are available to assess the association between PECC status, quality of care and outcomes for children. This work will address this knowledge gap to identify actionable strategies to improve care for children receiving care in general EDs.

PI_NAMEs: SAMUELS-KALOW, MARGARET EMILY (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;administrative database;Admission activity;adolescent health;Affect;care outcomes;Caring;Case Mixes;Characteristics;Child;Child Care;Child Health;Childhood;Clinical;Data;Databases;Disparity;disparity reduction;Emergency Care;Emergency department visit;Emergency Medicine;emergency settings;Ensure;Equipment;Equipment and supply inventories;Ethnic Origin;Evidence based intervention;experience;Face;Geography;Goals;Grant;Health Care Costs;health care disparity;health disparity;Health Services Research;Hospital Mortality;Hospitals;Image;implementation determinants;improved;improved outcome;Individual;Inpatients;Insurance;Insurance Coverage;interest;Interview;Investigation;Knowledge;Link;Measures;Mediator;medical specialties;member;Minority;Mission;mortality;multilevel analysis;National Institute of Child Health and Human Development;Nurses;Outcome;Patients;pediatric emergency;Pediatric Hospitals;pediatric patients;Physicians;Policies;Population;Process;process improvement;Public Health;Quality of Care;Race;Readiness;Reduce health disparities;Research;Resources;Role;social;Strategic Planning;System;Training;Travel;United States;United States Agency for Healthcare Research and Quality;Variant;Visit;Work

PROJECT_TITLE: Role of individual and hospital factors in quality of care for children in EDs

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative (3 sentences): We have developed a research network of pediatric critical care physicians across 5 academic centers to enroll 370 children in a Phase III double-masked placebo-controlled randomized trial of high-dose AZM [20 mg/kg (IV) x 3 days] to test the overarching hypothesis that administration of AZM during acute, RSV-induced respiratory failure be beneficial. We will test whether high-dose AZM administration will result in 1. decreased length of hospital stay, duration of ICU stay and duration of oxygen therapy, 2. decreased number of wheezing episodes and time to first wheeze 12 months post-acute infection, and 3. whether nasal markers of matrix metalloproteinase-9 driven lung inflammation will be decreased in patients receiving AZM, and predictive of outcome. A positive result from this trial will represent a paradigm shift in the management of severe RSV infection, as the first successful treatment for acute and post-RSV related respiratory exacerbation and has the potential to identify novel biomarkers of disease outcome.

PI_NAMEs: KONG, MICHELE  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Academy;Acute;acute infection;Acute respiratory failure;Admission activity;Age;Airway Disease;American;Anti-Inflammatory Agents;Antibiotics;Applications Grants;Arrhythmia;aspirate;Azithromycin;biomarker identification;Bronchiolitis;burden of illness;Cannulas;Cessation of life;Child;Child Health;Childhood;Chronic;Clinical;Continuous Positive Airway Pressure;cost;Critical Care;Data;Disease Outcome;Dose;Double-Blind Method;Drug usage;effective intervention;Effectiveness;effectiveness evaluation;Electrocardiogram;endotracheal;Enrollment;Exclusion Criteria;Future;Gelatinase B;Guidelines;Heart Diseases;Heart Rate;Home;Hospitalization;Human;IL8 gene;Immune response;immunoregulation;inclusion criteria;infant morbidity;Inflammatory;Injury;Length;Length of Stay;Leukocyte Elastase;Lung;Lung Diseases;Macrolides;Masks;Measurement;Measures;Mechanical ventilation;Mediating;millisecond;mouse model;Nose;novel marker;Outcome;outcome prediction;Oxygen Therapy Care;participant enrollment;Pathway interactions;Patients;Pediatrics;Peptide Hydrolases;Phase;Physicians;Placebo Control;Placebos;Pneumonia;Positive-Pressure Respiration;Primary Infection;Public Health;Pulmonary Inflammation;Pyloric Stenosis;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recording of previous events;Recovery;Research;respiratory;Respiratory Failure;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Safety;Secondary to;Severity of illness;Suction;Supportive care;System;Techniques;Testing;therapeutic target;Time;Tissue Inhibitor of Metalloproteinase-1;Tissue Inhibitor of Metalloproteinases;ventilation;Viral;Viral Load result;Viral Pathogenesis;Virus Diseases;Virus Replication;Wheezing;Work

PROJECT_TITLE: A Phase III Randomized Controlled Trial of Azithromycin for RSV-induced Respiratory Failure in Children

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Kidney Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Empagliflozin, a novel diabetic medication that targets the kidney, has recently been shown to improve cardiovascular survival in diabetic and non-diabetic patients with minimal to moderate kidney dysfunction. We will examine if empagliflozin is safe in patients with end-stage kidney disease on chronic dialysis. If our study shows that empagliflozin is safe and is well tolerated in dialysis patients, it will encourage future studies to evaluate its efficacy to reduce heart failure risk and improve survival in dialysis patients and provide a new potential therapeutic option.

PI_NAMEs: CHO, MONIQUE EUN HEE (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: absorption;Accounting;active method;Adherence;arm;Arrhythmia;Bioenergetics;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Clinical;Clinical Trials;Complication;coronary fibrosis;Data;Death Rate;Development;Diabetes Mellitus;diabetic;Diagnosis;Dialysis patients;Dialysis procedure;Disease;Dose;Double-Blind Method;Drug Kinetics;effective intervention;Electrophysiology (science);End stage renal failure;Equilibrium;Exclusion;Fibrosis;Functional disorder;Future;General Population;Glucose;Glycosuria;Heart;Heart failure;Hemodialysis;Homeostasis;Hospitalization;Hypoglycemia;Hypoglycemic Agents;Impairment;improved;inhibitor;Insulin Resistance;Kidney;kidney dysfunction;Kidney Failure;Knowledge;Left Ventricular Hypertrophy;Mediating;Metabolic;Mission;Mitochondria;mortality;Multi-Institutional Clinical Trial;Myocardial;Myocardium;National Institute of Diabetes and Digestive and Kidney Diseases;Natriuresis;Nephrons;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Participant;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;Placebo Control;Placebos;Population;prevent;Procedures;Proximal Kidney Tubules;Questionnaires;Randomized;randomized, clinical trials;recruit;Reducing Agents;Renal function;response;Risk;Safety;Sodium;Sodium-Hydrogen Antiporter;sudden cardiac death;Sudden Death;symporter;Therapeutic;translational impact;treatment group;Ventricular

PROJECT_TITLE: Safety, tolerability, and feasibility of empagliflozin therapy in dialysis-dependent ESKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health

ORG_CITY: BETHLEHEM

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: Aggression varies substantially between different people, and extreme levels of aggression have negative consequences for individuals and society. This proposal will leverage genetic tools and resources in an emerging model system to investigate the genetic and neuronal basis of variability in aggression. Elucidating the genetic architecture underlying differences in aggression in natural populations will help establish why individual differences in social behaviors manifest, which could lead to long term solutions for treatment and management.

PI_NAMEs: KOWALKO, JOHANNA E. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Aggressive behavior;base;Behavior;Behavioral;Biological Models;blind;Candidate Disease Gene;Chromosome Mapping;Complex;Evolution;Fishes;Genetic;genetic architecture;genetic variant;Genetic Variation;genome resource;Goals;Human;Individual;Individual Differences;insight;Laboratories;Methods;Mexican;model organism;Molecular;Morphology;Natural Selections;neuromechanism;Neurons;Organism;Persons;Physiological;Population;programs;Research;Resources;Role;Social Behavior;Societies;Surface;System;Testing;tool;trait

PROJECT_TITLE: Evolutionary approaches to identify genetic architecture regulating aggression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative: This project will utilize microglia and cerebral organoids derived from induced pluripotent stem cells to study how HIV causes inflammation and neuronal damage in the brain, leading to HIV-associated neurocognitive disorders (HAND). Signaling pathways that result in inflammation following HIV infection of microglia will be a focus of investigation. The mechanisms underlying the adverse effects of methamphetamine on the HIV- infected brain will defined in this model system.

PI_NAMEs: SPEARMAN, PAUL W. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;acute infection;Adverse effects;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;antiretroviral therapy;Astrocytes;Autopsy;Biological Models;Brain;brain cell;cell injury;Cell surface;cell type;Cells;Central Nervous System Diseases;Cerebrum;Chronic;chronic infection;Clinical Research;comorbidity;crosslink;cytokine;defined contribution;Development;Electrophysiology (science);Evaluation;experimental study;Functional disorder;glial activation;Health;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Immunofluorescence Microscopy;Individual;induced pluripotent stem cell;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;Investigation;Knock-out;knockout gene;life span;Measures;Mediating;Methamphetamine;methamphetamine effect;methamphetamine exposure;methamphetamine use;Microelectrodes;Microglia;Modeling;Molecular;Morbidity - disease rate;Multiple Sclerosis;Myeloid Cells;neural;Neurocognitive Deficit;neurocognitive disorder;neuroinflammation;Neuronal Dysfunction;Neurons;NF-kappa B;Organoids;particle;Pathogenesis;Pathway interactions;Persons;Play;Process;Production;recruit;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SIV;Source;src-Family Kinases;Stimulant;Study models;SYK gene;Testing;Time;transcriptome sequencing;Tyrosine Kinase Inhibitor;Viral;Viral Proteins;Viral reservoir

PROJECT_TITLE: Modeling HIV and methamphetamine-induced neuroinflammation in cerebral organoids


ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE This project examines epigenetic control of gene regulation and chromatin organization that differ between maternally and paternally inherited DNA within offspring. It will also investigate the functions of genes with parent-specific expression, with direct implications for understanding the basic biology underlying human imprinted disorders.

PI_NAMEs: WHIPPLE, AMANDA JOY (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;Alleles;Angelman Syndrome;Biological Models;Biological Process;Biology;Cell Physiology;cell type;Chemicals;Chromatin;Chromatin Structure;Chromosomes;Complementary RNA;Development;Disease;Disease susceptibility;DNA;Epigenetic Process;experience;experimental study;Future;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genome;Genomic Imprinting;Growth;Human;imprint;Individual;Inherited;Ligation;Metabolic;Modification;Molecular;neurodevelopment;Neuronal Differentiation;offspring;Organism;parental influence;Parents;Pathway interactions;Physiological;Play;Prader-Willi Syndrome;RNA;Role;Scientist;Small Nucleolar RNA;Symptoms;Tissues;tool;transcriptomics;Untranslated RNA;Work

PROJECT_TITLE: Investigating molecular mechanisms and cellular functions of genomic imprinting

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Programmed cell death signaling pathways are integral components of the host response to infection, yet how they contribute to inflammation during sepsis remains incompletely defined. This program aims to define mechanisms by which cell death signaling pathways contribute to septic inflammation and inflammatory dysregulation, thereby identifying therapeutic targets and strategies for a lethal and highly prevalent disease process.

PI_NAMEs: LYONS, JOHN DANIEL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Animals;Antibiotics;Apoptosis;beneficiary;Biological Assay;Cell Death;Cell Death Signaling Process;Cell Fate Control;Cells;Clinical;cost;Critical Illness;Data;Disease;experimental study;Healthcare Systems;Homeostasis;Host Defense;Human;Human Cell Line;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;insight;Invaded;Knowledge;Measures;Medicare;Modernization;novel therapeutic intervention;Organ failure;pathogen;Pathway interactions;Patients;Persons;Process;programs;Proteins;Public Health;response;Sampling;Sepsis;septic;Signal Pathway;Stimulus;Supportive care;targeted treatment;Techniques;therapeutic target;Tissues;United States

PROJECT_TITLE: Cell death proteins as inflammatory mediators in sepsis

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The parasympathetic nervous system controls heart rate and this is perturbed in many heart diseases, including heart failure, arrhythmia after myocardial infarction, cardiac sudden death, and cardiac autonomic neuropathy (CAN) in diabetes. Parasympathetic control of the heart (e.g., heart rate variability) is a robust indicator of cardiac health and predictor of mortality and morbidity, though the neurobiological basis of this control is only partly known. A better understanding of the parasympathetic cells, circuitry, and signals which control heart rate will reveal novel therapeutic targets and strategies for treating heart diseases.

PI_NAMEs: CAMPBELL, JOHN N (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Address;Anatomy;Anus;Arrhythmia;Atlases;Autonomic nervous system;autonomic neuropathy;Axon;Back;Baroreflex;biomarker validation;Blood Pressure;blood pressure elevation;Breathing;Bronchoconstriction;Cardiac;Cardiac health;Cardiovascular Diseases;Cells;Chest;Chronic;Circulation;Classification;Contracts;Cranial Nerves;Data;Deglutition;Diabetes Mellitus;Esophagus;Ganglia;Gene Expression;Genes;Genetic;Genetic Markers;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Rate;heart rate variability;Heterogeneity;hindbrain;Home;Human;Hypertension;Image;Implant;infection risk;insight;Label;Larynx;Learning;Lung;Maps;Measures;Mediating;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Motor Neurons;mouse model;Mus;Muscle;Myocardial Infarction;Nature;Nerve;Nervous System control;neural circuit;Neurobiology;Neurons;Neuropeptide Gene;new therapeutic target;novel marker;nucleus ambiguus;Operative Surgical Procedures;Optics;optogenetics;Organ;Output;Parasympathetic Nervous System;Pharyngeal structure;Physiological;Play;pre-clinical;Proteins;pulmonary function;Rabies;Receptor Gene;Reflex action;Research;Research Proposals;Resources;response;Rest;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Smooth Muscle;Specificity;Striated Muscles;sudden cardiac death;Synapses;Taxonomy;Therapeutic Intervention;therapeutic target;Trachea;transcriptomics;Transgenic Mice;vagus nerve stimulation;Vagus nerve structure;vector;Viral Vector

PROJECT_TITLE: Molecular and Functional Taxonomy of Cardiovagal Neurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Heart Disease;Human Genome;Physical Activity;Precision Medicine;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) is a critical public health issue characterize by heterogeneous pathologic mechanisms that contribute to symptoms and poor outcomes across several different subgroups of patients. Understanding to the heterogeneous nature of HFpEF, randomized trials have been unable to identify pharmacological therapies that improve symptoms or clinical outcomes in patients with HFpEF on a large scale. The goal of the current proposal is to establish a large cohort of deeply phenotyped patients with HF to help with better understanding differential mechanisms of adverse outcomes in patients with HFpEF and identifying subgroups of patients that are likely to benefit from targeted therapy.

PI_NAMEs: CHIRINOS MEDINA, JULIO ALONSO (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Abdomen;Accelerometer;adjudication;Adult;adverse outcome;Aerobic;Affect;Anxiety;Aorta;arterial tonometry;Bicycling;biobank;Bioinformatics;bioinformatics tool;Biopsy;Blood;Blood specimen;Blood Vessels;Body Composition;Body measure procedure;Cardiac;Cardiopulmonary;Cardiovascular system;Cessation of life;Characteristics;Cine Magnetic Resonance Imaging;Clinical;clinical center;Clinical Data;cohort;Collection;Communities;Coupled;Coupling;Data;Data Collection;Detection;disorder subtype;Doppler Echocardiography;Echocardiography;Economic Burden;EFRAC;electric impedance;Electronic Health Record;endophenotype;Ergometry;Exercise;Exercise Test;Fatty acid glycerol esters;Fibrosis;follow-up;functional status;Gases;Goals;Heart;Heart Atrium;Heart failure;Heterogeneity;Hip region structure;Home;Home Blood Pressure Monitoring;Hospitalization;Human;Hypertension;Hypertrophy;in vivo;Individual;innovation;Left;Left Ventricular Mass;Liver;Magnetic Resonance Imaging;Maps;Measures;member;Mental Depression;metabolomics;Methods;MicroRNAs;molecular phenotype;Monitor;multiple omics;myocardial biopsy;Myocardial Infarction;Myocardial tissue;Nature;neurocognitive test;next generation;novel strategies;Outcome;Participant;participant enrollment;Pathogenicity;Pathologic;patient oriented;Patient Outcomes Assessments;patient subsets;Patients;Pericardial body location;pharmacologic;phase II trial;phenome;phenomics;Phenotype;phenotypic data;Physical activity;Plasma;Polysomnography;Population Control;preservation;pressure;Process;prospective;Prospective cohort;Proteomics;Protocols documentation;Public Health;Pulmonary function tests;Pump;Quality of life;randomized trial;randomized, clinical trials;Recording of previous events;Research;Research Personnel;Rest;Sampling;Skeletal Muscle;Sleep;social;social health determinants;socioeconomics;Stroke;subcutaneous;Supination;symptomatic improvement;Symptoms;targeted treatment;Techniques;therapeutically effective;Tissues;transcriptome sequencing;treatment response;urinary;Urine;Vascular resistance;Venous;Ventricular;Visceral;Work

PROJECT_TITLE: HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE The objective of this study is to improve the performance of lung cancer screening by optimizing the management of screen-detected pulmonary nodules. To do this, we will develop a simulation model, the Multi- Racial and Ethnic Lung Cancer Model (MELCAM), to perform comparative effectiveness and cost- effectiveness analyses to identify optimal nodule management algorithm(s). Our results will reduce harms from false-positive findings and maximize benefits from lung cancer early cancer detection by computed tomography screening.

PI_NAMEs: KONG, CHUNG YIN  (contact);SIGEL, KEITH MAGNUS;WISNIVESKY, JUAN P

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Age;Algorithms;American;Behavior;Biopsy;British;burden of illness;Cancer Control;Cancer Etiology;Cancer Intervention and Surveillance Modeling Network;Cancer Model;cancer risk;Cessation of life;Characteristics;Chest;Clinical Data;Clinical Trials;clinically significant;comorbidity;comparative effectiveness;computed tomography screening;cost;cost effectiveness;Cost Effectiveness Analysis;Costs and Benefits;diagnostic accuracy;Disparity;Eligibility Determination;Enrollment;Equilibrium;ethnic diversity;Ethnic Origin;Ethnic Population;Evaluation;follow-up;Goals;Growth;Guidelines;Harm Reduction;Image;Impact evaluation;improved;innovation;Life Expectancy;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;men;Minority;Minority Groups;Modeling;models and simulation;mortality;mortality risk;multi-racial;Natural History;Nodule;novel;Outcome;Participant;Patients;Pattern;Performance;personalized approach;personalized management;Policies;Population;Population Heterogeneity;Procedures;programs;Protocols documentation;Quality of life;Quality-Adjusted Life Years;Race;racial diversity;racial population;Recommendation;Registries;Risk;Sampling;screening;Screening for cancer;screening guidelines;sex;Smoking;Smoking History;Societies;Structure;Techniques;Testing;tool;Woman

PROJECT_TITLE: Optimizing Lung Cancer Screening Nodule Evaluation

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE Wolbachia bacteria are the most common endosymbionts in nature. Vector-control groups are attempting to establish pathogen-blocking Wolbachia strains in mosquito populations to reduce the transmission of human diseases, particularly dengue and Zika. This research will identify and evaluate the mechanisms that govern the spread and maintenance of Wolbachia in host populations.

PI_NAMEs: COOPER, BRANDON S. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: The evolutionary genetics and genomics of Wolbachia effects on host physiology


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Cardiovascular disease is the leading cause of death worldwide. The Translational Cardiovascular Research and Entrepreneurship Training Program is focused on training the next generation of PhD scientists to be capable of both making discoveries in the molecular mechanisms of cardiovascular disease and leading research programs to guide the translation of those discoveries into effective therapies that can be applied in clinical medicine. This training program will therefore contribute to accelerating the translation of laboratory discoveries into clinical therapies that directly impact our ability to improve treatment of human cardiovascular disease.

PI_NAMEs: MICHELE, DANIEL E (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TITLE: Training Program in Translational Cardiovascular Research and Entrepreneurship

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: PROJECT NARRATIVE Public Health Relevance: The volume of biomedical research literature and data, and electronic health records is exploding exponentially, making it almost impossible for investigators to query such almost infinite information for new connections that might exploited to improve human health. This application proposes to develop a next generation artificial intelligence-based program to rapidly and efficiently query biomedical and health record information for new, unexplored connections between HIV infection and substanses of abuse comorbidities. These new connections will furthermore be prioritized for those connections that might already have a potential treatment, called drug repurposing.

PI_NAMEs: SAFRO, ILYA ;SHTUTMAN, MICHAEL  (contact);SUTTON, SHAWN SCOTT;WYATT, MICHAEL D.

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Accidents;Acquired Immunodeficiency Syndrome;Age;Algorithms;Amphetamines;Animals;antiretroviral therapy;Artificial Intelligence;artificial intelligence algorithm;Biological;Biomedical Research;candidate selection;Caring;Clinical;clinical development;Clinical Trials;Cocaine;Cognitive;Cognitive deficits;comorbidity;Data;Data Analyses;Data Set;deep learning model;Development;Dimensions;Disease;drug candidate;Drug Combinations;Drug Modelings;drug of abuse;drug repurposing;Drug Side Effects;Electronic Health Record;experience;Explosion;Gene Expression;gene interaction;Generations;Genes;Goals;Health;health record;Health Status;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV Seropositivity;HIV-1;Human;improved;Individual;Infrastructure;inquiry-based learning;Intelligence;Knowledge;Knowledge Discovery;life span;Literature;Machine Learning;machine learning algorithm;Manuals;Medical;Memory Loss;Mining;Modeling;mortality;multiple data sources;network informatics;neuroAIDS;Neurocognitive Deficit;Neurologic Effect;Neurons;neurotoxic;neurotoxicity;next generation;novel;Opioid;Outcome;Overdose;Pathology;Patients;peer;Persons;Pharmaceutical Preparations;Population;prevent;programs;PubChem;public health relevance;Quality of life;Research;Research Personnel;Severities;Signal Transduction;small molecule;Substance of Abuse;Substance Use Disorder;Suicide;System;Testing;text searching;tool;Triage;United States Department of Veterans Affairs;Validation;Veterans;Work;World Health Organization

PROJECT_TITLE: Knowledge discovery and machine learning to elucidate the mechanisms of HIV activity and interaction with substance use disorder


NIH_SPENDING_CATS: Clinical Research;Genetics;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project narrative The proposed research is relevant globally to public health because each year injury is a leading cause of over four million deaths, and over half of survivors suffer from organ failure. Platelets contribute to the pathobiology of organ failure through thromboinflammation, and in many diseases characterized by organ failure, studying the platelet transcriptome has improved mechanistic understandings and driven exploration of platelet-based therapeutics. Platelets are anucleate and lack RNA synthesis, providing the cleanest transcriptomic view of RNA modification in human biology; thus, this proposal seeks to re-imagine how we understand, measure, and intervene on early alterations in platelets after injury by focusing on the platelet transcriptome to 1) identify novel molecular biomarkers and preventative targets of development of organ failure after injury, and 2) innovate our understanding of physiologically driven RNA modification through the ideal anucleate biology of platelets under the optimal acute physiologic changes of injury.

PI_NAMEs: KORNBLITH, LUCY ZUMWINKLE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Address;Area;Award;Basic Science;Biological Models;Biological Process;Biology;Blood Platelets;Caring;Cause of Death;Cessation of life;clinically relevant;Development;Disease;disease diagnosis;Early identification;Early treatment;Foundations;Functional disorder;Genetic Transcription;Health;high risk;Human Biology;improved;in vitro Model;in vivo Model;Infrastructure;injured;Injury;injury burden;innovation;K-Series Research Career Programs;Knowledge;Measures;Megakaryocytes;Mentors;Methods;Mission;Modification;molecular marker;Morbidity - disease rate;mortality;National Institute of General Medical Sciences;next generation sequencing;novel;Organ failure;organ growth;Patients;pharmacologic;Physiological;Physiology;platelet function;prevent;Prevention;Public Health;Research;research clinical testing;Research Personnel;Resolution;ribosome profiling;RNA;Sampling;Science;Scientist;severe injury;Signal Transduction;Site-Directed Mutagenesis;Surgeon;Survivors;Testing;Therapeutic;thromboinflammation;transcriptome;transcriptomics;Transgenic Organisms;translational study;Trauma

PROJECT_TITLE: The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) is common, its mechanisms are not well understood, and there are few proven treatments; this problem will be addressed by HeartShare. Our Wake Forest Atrium HeartShare Clinical Center will contribute thought leadership and data from our existing cohorts and trials, and deeply phenotype 250 HFpEF patients plus control participants according to a comprehensive state-of-the art protocol designed to understand cardiac, vascular, and extra-cardiac factors contributing to HFpEF.

PI_NAMEs: KITZMAN, DALANE W (contact)

PROJECT_TERMS: Abdomen;Acceleration;actigraphy;Address;Adipose tissue;Age;Aging;Aorta;Artificial Intelligence;bioinformatics tool;Biological;Biological Markers;Biopsy;Blood;Blood Vessels;Body Composition;Brain;Cardiac;cardiac magnetic resonance imaging;career;Clinical;clinical center;Cognition;cohort;Collaborations;comorbidity;Complement;Consensus;Consent;Control Groups;Creativeness;Data;data repository;deep learning;design;Development;Diabetes Mellitus;DNA;Educational workshop;EFRAC;Electrocardiogram;Electronic Health Record;Enrollment;Ensure;Evidence based treatment;experience;frailty;Functional disorder;Funding;Future;gender diversity;Genetic Materials;Goals;Health;Health system;Heart;Heart Atrium;Heart failure;Heterogeneity;Hypertension;Image;innovation;insight;Institution;International;Intervention;Lead;Leadership;Lung;Machine Learning;Mental Depression;microbiome;Mitochondria;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Muscle;new therapeutic target;novel;Obesity;Outcome;Paper;Participant;Pathogenesis;Patient Recruitments;Patients;Phase;Phenotype;Physical activity;Plasma;Population Heterogeneity;Population Study;preservation;Prevalence;primary outcome;Prognosis;programs;prospective;Protocols documentation;Qualifying;Quality of life;racial diversity;randomized trial;Recommendation;recruit;Reporting;Research Personnel;Research Priority;Resources;response;retention rate;Sampling;Seminal;Serum;signal processing;Signal Transduction;Skeletal Muscle;Specimen;Structure;success;Syndrome;Techniques;Testing;therapeutic target;Thigh structure;Tissue Sample;United States National Institutes of Health;Visit;Work


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative In the human body, rhythms of metabolism play an essential role in maintaining normal function. Disrupting these rhythms can contribute to many types of disease, including diabetes, cancer, and aging. However, the effect that metabolic rhythms have on cells is still not fully understood. This study will investigate how changing metabolic rhythms can activate or deactivate certain genes, helping us to understand the connection between these rhythms and disease.

PI_NAMEs: ALBECK, JOHN G. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Aging;Autophagocytosis;Biological Assay;cell growth;cell growth regulation;Cells;Chronic Disease;Diabetes Mellitus;Disease;drug sensitivity;FOXO3A gene;Gene Expression;Genes;Genetic Transcription;Human body;inducible gene expression;Inflammation;inhibitor;Kinetics;Lysosomes;Malignant Neoplasms;mathematical model;Measures;Metabolic;Metabolic stress;Metabolism;Metformin;Methods;Modeling;novel strategies;pharmacologic;Play;Process;programs;Reporter;response;Role;senescence;Stress;Systems Biology;Testing;transcription factor;transcriptome;Translations;Work

PROJECT_TITLE: Control of gene expression by dynamic metabolic oscillations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: PROJECT NARRATIVE Pulmonary nodules (PNs) are detected via computed tomography (CT) in approximately 2 million adults in the U.S. each year, but the current diagnostic process for PN evaluation and management results in delayed cancer diagnoses and unnecessary invasive biopsy procedures among individuals with benign diagnoses. Existing clinical malignancy risk prediction models provide only modest diagnostic accuracy, but radiomics- based computer-aided diagnosis (CAD) tools, which synthesize quantitative features from CT imaging data to predict cancer risk, may help clinicians estimate PN malignancy risk more accurately. This proposal will evaluate the clinical utility, clinical effectiveness, and cost-effectiveness of a CAD-based risk stratification strategy for PN evaluation and management, with the goal of optimizing the PN diagnostic process to improve patient outcomes.

PI_NAMEs: KIM, ROGER YEON-KYU (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adult;Advisory Committees;Agreement;Award;base;Benign;Biometry;Biopsy;cancer care;Cancer Center;cancer diagnosis;cancer risk;career;career development;Classification;Clinic;Clinical;Clinical effectiveness;Clinical Management;Clinical Oncology;clinical practice;Clinical Research;clinical risk;Clinical Trials;Clinical Trials Design;clinically significant;cohort;collaborative environment;comparative effectiveness trial;Complex;Computer-Assisted Diagnosis;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Data;Development Plans;Diagnosis;Diagnostic;diagnostic accuracy;Early Diagnosis;Effectiveness;effectiveness evaluation;Epidemiology;Evaluation;experience;Eye;Face;Financial Support;Goals;Human;Image;improved;indexing;Individual;innovation;Institution;Intervention;K-Series Research Career Programs;Knowledge;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Mentors;Mentorship;Methods;Modeling;multidisciplinary;new technology;novel;Outcome;participant enrollment;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;Physicians;Positioning Attribute;Postdoctoral Fellow;primary outcome;Probability;Procedures;Process;Publishing;Pulmonary Challenge;Pulmonology;Quality-Adjusted Life Years;radiomics;randomized, clinical trials;Research;research clinical testing;Research Personnel;Research Training;Retrospective cohort;Retrospective cohort study;Risk;Risk Estimate;risk prediction model;risk stratification;Scientist;serial imaging;skill acquisition;supportive environment;Testing;Thoracic Oncology;Time;tool;Training;treatment as usual;Universities;uptake;Use Effectiveness;Vision;X-Ray Computed Tomography

PROJECT_TITLE: Assessment of a Radiomics-Based Computer-Aided Diagnosis Tool for Cancer Risk Stratification of Pulmonary Nodules

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Heart Disease - Coronary Heart Disease;Infertility;Neurosciences;Prevention;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: NARRATIVE Hypothalamic amenorrhea (HA) occurs during reproductive years and results in ovulatory dysfunction, anovulation and infertility which can be prolonged from months to years and is characterized by varying combinations of psychosocial stress, anxiety, high levels of physical activity and/or weight loss. Data from our group indicates that one-third of women with HA (mean age: 27 yrs) have preclinical CVD measured noninvasively as vascular dysfunction and vascular inflammation. Our application will study HA as a marker of fertility status for cardiovascular health and perform dense-phenotyping using remote patient monitoring and patient reported outcomes to determine which HA phenotype are related to preclinical CVD and inflammation, and expand our analyses to a large population cohort with 30-year CVD risk factors and CVD event follow-up.

PI_NAMEs: SHUFELT, CHRISANDRA LEE (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;adjudication;Adrenal Gland Hyperfunction;Age;Amenorrhea;Anovulation;Anxiety;Biological Markers;Blood Vessels;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cause of Death;Chronic Kidney Failure;Clinical;clinical care;cohort;Complex;Coronary Angiography;Coronary Arteriosclerosis;Coronary heart disease;cytokine;Data;design;Development;Diet Records;direct application;Disease;Disease Progression;Early identification;Energy Intake;Epidemic;Evaluation;Event;Fertility;fitbit;follow-up;Funding;Funding Opportunities;Future;Glucose;Goals;Health;health disparities in women;Health Personnel;High Risk Woman;hormone therapy;Hormones;Hypothalamic structure;Hypothyroidism;improved;indexing;Infertility;Inflammation;innovation;Intervention Trial;Ischemia;Left;Leptin;Life;life span;Low Prevalence;Measures;Mediating;Menstrual cycle;Menstruation Disturbances;Monitor;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;neurocognitive disorder;Neurosecretory Systems;Nurses' Health Study;nutrition;Organ;Outcome;ovarian dysfunction;Patient Outcomes Assessments;Patients;Pattern;Peripheral;Phenotype;Physical activity;Polycystic Ovary Syndrome;Population;Population Study;pre-clinical;premature;Premenopause;Prevention strategy;Preventive;Preventive care;Prospective, cohort study;Psychosocial Stress;Questionnaires;reactive hyperemia;recruit;Registries;remote patient monitoring;Reporting;reproductive;Reproductive Endocrinology;Reproductive system;Research;Risk Factors;Stroke;Syndrome;Translating;Vascular Diseases;vascular inflammation;Woman;Women's Health;Women's mortality;Women's study;young woman

PROJECT_TITLE: Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Patient Safety;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Allogeneic Human MEsenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome (HLHS): a Phase IIb Clinical Trial (ELPIS) requires a Data Coordinating Center (DCC) for project coordination, administration, data management, and biostatistical support. ELPIS is designed to determine the efficacy of mesenchymal stem cell (MSC) treatment in HLHS patients undergoing the stage II operation for HLHS by determining the improvement of right ventricular function as measured by the diastolic mass indexed on cardiac magnetic resonance imaging (CMRI). When the DCC fulfills its requirements in collaboration with the Clinical Coordinating Center (CCC), we will be able to answer this important research question to determine the efficacy of MSC's for a primary endpoint with clinical relevance to this HLHS patient population.

PI_NAMEs: LAI, DEJIAN  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Adherence;adherence rate;Adverse event;adverse event monitoring;Allogenic;Anastomosis - action;Ancillary Study;Annual Reports;authority;Big Data Methods;Biometry;Budgets;cardiac magnetic resonance imaging;Case Report Form;Certification;Child;Clinical;clinical center;Clinical Management;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically relevant;Collaborations;Collection;Common Data Element;Communication;Communities;Consultations;Data;Data Analytics;Data Collection;Data Coordinating Center;data management;data repository;Data Set;Databases;design;Development;Documentation;efficacy evaluation;electronic data;electronic data capture system;Electronics;Enrollment;Ensure;Evaluation;Event;follow-up;Fontan Procedure;Goals;Human;Hypoplastic Left Heart Syndrome;improved;indexing;Infant;Information Dissemination;Injections;Institutional Review Boards;Insurance;Laboratories;Licensing;Logistics;Manuals;Measures;meetings;Mesenchymal Stem Cells;Monitor;National Heart, Lung, and Blood Institute;operation;Participant;Patient Care;patient population;Patients;payment;Performance;Phase;Policies;primary endpoint;Procedures;Process;Protocols documentation;Publications;Quality Control;recruit;Reporting;Research;Research Design;Research Personnel;Right Ventricular Function;Safety;Schedule;Secure;Statistical Data Interpretation;stem cell therapy;symposium;System;Time;timeline;Validation;Ventricular;Visit;Voting;web site;Work;working group

PROJECT_TITLE: The Allogeneic Human Mesenchymal Stem Cell (MSCs) injection in Patients with Hypoplastic Left Heart Sydrome: A Phase IIb Clinical Trial (ELPIS)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We propose a training program in human and translational immunology. The program is designed to provide the skill set necessary to train the next generation of translational investigators in immunologic approaches in order to advance therapeutic techniques and improve our understanding of the human immune system.

PI_NAMEs: CRAFT, JOSEPH EDGAR;HEROLD, KEVAN C (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Human and Translational Immunology Training Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE/RELEVANCE The incidence of KSHV infection and associated disease in the developing and developed world will continue to grow as KSHV transmission spreads and the population becomes immunodeficient due to HIV-1 infection or iatrogenic agents associated with organ transplantation. Unfortunately, despite the gains documented with anti- retroviral therapy to inhibit progression to AIDS, KSHV-associated disease is still widespread, implying more effective therapies are required to stem the incidence of disease. The results from the proposed studies utilizing the well-studied and characterized nonhuman primate (NHP) model should help elucidate the roles of viral factors involved in infection, persistence and disease.

PI_NAMEs: WONG, SCOTT W (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: acquired immunodeficiency;Acute;acute infection;adaptive immune response;Address;Affect;Animal Model;Animals;antiretroviral therapy;B-Lymphocytes;Biological;Cessation of life;chronic autoimmune disease;chronic infection;Clinical;co-infection;Color;Data;Diarrhea;Disease;effective therapy;Engineering;Etiology;experimental study;Fibromatoses;Flow Cytometry;Gene Expression;Gene Expression Profile;Genome;Goals;Hepatitis;Herpesviridae Infections;HIV;HIV-1;Homologous Gene;Human;Human Herpesvirus 8;Hyperplasia;Iatrogenesis;Immune response;Immunocompetent;immunodeficiency;Immunologics;In Vitro;in vivo;in vivo Model;Incidence;Infection;Innate Immune Response;insight;Integration Host Factors;Interferons;Intestines;Kaposi Sarcoma;Kinetics;lymph nodes;Lymphoproliferative Disorders;Macaca mulatta;macromolecule;Maintenance;Malignant Neoplasms;Measures;Mediating;MicroRNAs;Modeling;Molecular;Molecular Analysis;Multicentric Angiofollicular Lymphoid Hyperplasia;Mutation;nano-string;Non-Hodgkin's Lymphoma;nonhuman primate;Nonsense Mutation;novel;Open Reading Frames;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patients;peripheral blood;Phenotype;Play;Population;Predisposition;Primates;Property;Proteins;recombinant virus;Recombinants;repaired;Research Personnel;Research Project Grants;Respiratory Disease;response;Retroperitoneal Space;Rhadinovirus;Rhesus;Role;Saliva;Sampling;Scientist;Series;single cell sequencing;single-cell RNA sequencing;SIV;stem;Syndrome;Technology;transcriptome sequencing;transmission process;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Load result;Viral Pathogenesis;Virus;Virus Diseases

PROJECT_TITLE: Rhesus HHV-8 homologue in AIDS-related malignancies

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative The aim of this application is to understand the biological impacts of small RNAs in establishing epigenetic states. Small RNAs regulate gene expression on several levels and they impact disease states ranging from cancer to neurodegeneration. They also serve as tools for understanding normal and aberrant biological processes and will perhaps transform clinical practice by serving as the basis for a new generation of therapeutic agents.

PI_NAMEs: FEJES TOTH, KATALIN  (contact)

PROJECT_TERMS: Adult;Animals;Binding;Binding Proteins;Biochemical;Biogenesis;Biological;Biological Process;Biology;Cell Differentiation process;Cell Nucleus;cell type;Chromatin;Chromatin Remodeling Factor;Chromatin Structure;clinical practice;Complex;Cytoplasm;Deposition;Development;Disease;DNA Damage;DNA Transposable Elements;egg;Embryo;Embryonic Development;Ensure;Epigenetic Process;experimental study;Fertility;fly;Gametogenesis;Gene Expression;gene repression;Gene Silencing;Generations;genetic approach;Genetic Transcription;Genome;genome integrity;Genome Stability;Genomics;Germ Cells;Germ Lines;Goals;Gonadal structure;Heterochromatin;histone methyltransferase;Human;Image;Individual;individualized medicine;Knowledge;Ligase;Link;Maintenance;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;Multiprotein Complexes;Nerve Degeneration;neuronal cell body;next generation;Nuclear;nuclease;Oogenesis;Pathway interactions;piRNA;Play;Post-Translational Protein Processing;prevent;Process;Proteins;Proteomics;recruit;Regulation;Reporter;Repression;RNA;Role;Selfish Genes;Signal Transduction;Site;Small RNA;Small Ubiquitin-Related Modifier Proteins;Somatic Cell;Specific qualifier value;Sterility;Structure of primordial sex cell;Sumoylation Pathway;System;targeted treatment;Testing;Therapeutic Agents;tool;Transcript;transgenerational epigenetic inheritance;transmission process;treatment strategy;ubiquitin-protein ligase;Untranslated RNA;Work

PROJECT_TITLE: Understanding the mechanism of Piwi-induced transcriptional silencing

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Nutrition;Patient Safety;Prevention

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Oral immunotherapy (OIT) is a promising treatment for food allergy; however, it may cause gastrointestinal side effects including eosinophilic esophagitis (EoE). The overall goal of the proposed research is to understand the mechanisms underlying the gastrointestinal side effects of OIT. We will pursue this goal by studying eosinophil and other immune responses in the blood and the esophagus during a clinical trial of dupilumab with milk OIT, which may help us improve treatments for food allergy and better understand the pathogenesis of EoE.

PI_NAMEs: WRIGHT, BENJAMIN L. (contact)

PROJECT_TERMS: Acceleration;Address;Adverse effects;Allergic;Allergic Disease;Allergy to peanuts;Antibodies;Applications Grants;Arizona;Asthma;Atopic Dermatitis;Award;Basal Cell Hyperplasia;Basic Science;Bioethics;Biological Markers;Biology;Biometry;Blood;career;career development;Caring;CCL26 gene;Cell Adhesion Molecules;Cellular Immunology;Characteristics;Chemotactic Factors;Chronic;Clinic;Clinical;Clinical Immunology;clinical practice;Clinical Research;Clinical Trials;Collaborations;cytokine;Data;desensitization;design;Development;Diagnosis;Disease;double-blind placebo controlled trial;Edema;Endoscopic Biopsy;Environment;eosinophil;Eosinophilia;Eosinophilic Esophagitis;Eosinophilic Gastrointestinal Disease;eosinophilic inflammation;Epithelium;Esophagus;Event;experience;Exposure to;Extracellular Space;FDA approved;Food;food antigen;Food Hypersensitivity;Functional disorder;Funding;gastrointestinal;gastrointestinal symptom;Goals;Health;Hour;Hypersensitivity;Iatrogenesis;IgE;Immune response;Immune Tolerance;Immunity;Immunologics;Immunology;immunotherapy clinical trials;improved;Individual;insight;Interleukin-13;Interleukin-4;International;Internships;Knowledge;Lead;Life;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Milk;Milk Hypersensitivity;minimally invasive;Monitor;Nose;novel;oral immunotherapy;Outcome;Parents;Pathogenesis;Patient Care;patient oriented research;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;placebo controlled trial;Placebos;polyposis;Predisposition;prevent;Production;professor;programs;prospective;Proteomics;Randomized;Request for Applications;Research;Research Design;Research Personnel;Research Proposals;Research Technics;Research Training;response;Risk;Safety;Sampling;side effect;Signal Transduction;skill acquisition;skills;Symptoms;Testing;Th2 Cells;Tissues;Training;Translating;Translational Research;treatment strategy;United States National Institutes of Health;Universities;Vascular Cell Adhesion Molecule-1

PROJECT_TITLE: Mechanisms of adverse gastrointestinal events during oral immunotherapy


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite the fact that a substantial number of children struggle with reading comprehension (RC), and that schools prominently focus on having adequate RC for various types of texts, including stories and informational text, there is scant knowledge about the neurocognitive correlates of RC for different text types, or how readers process texts for optimal RC. This project aims to determine which brain networks are: (1) differentially linked to various text types and reader profiles and (2) predict optimal RC outcomes in children ages 10-12. Our ultimate goal is to understand the best way for children to learn new information through reading so that we can better understand how to effectively individualize instruction in a way that maximizes academic success and prevents academic failure.

PI_NAMEs: CUTTING, LAURIE E (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Neural Correlates of Discourse Processing in Adolescents


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Centrosomes are structures inside cells that nucleate and organize long fibers called microtubules, which attach to DNA and separate it during embryo development and stem cell divisions. This proposal will determine how centrosomes assemble, generate thousands of microtubules, and resist microtubule-mediated forces without suffering mechanical failure. The long-term goal is to identify the molecular and material causes of disorders caused by centrosome dysregulation, such as microcephaly, primary dwarfism, and various cancers.

PI_NAMEs: WOODRUFF, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Molecular, material, and structural design principles of centrosomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: Convergent evidence from animal and human studies have strongly implicated functional perturbations in the subgenual anterior cingulate cortex (sgACC) in depression. However, it is not known how dysfunction within specific sub-circuits of this heterogenous structure map to specific depression-related symptom domains. To address this gap, we propose a rigorous translational neuroscience study to define the distinct circuit-specific mechanisms of anhedonia and anxiety in humans with depression, building upon work in non-human primates, and converging human evidence from our laboratories.

PI_NAMEs: MURROUGH, JAMES WARREN (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Address;Adult;Aftercare;analog;Anhedonia;Animals;Anterior;Anxiety;Area;Arousal;Behavior assessment;Behavioral;Brodmann's area;Callithrix;cingulate cortex;Clinical assessments;clinical heterogeneity;Development;Diagnostic;digital health;Disabling;Disease;Dose;Enrollment;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Glutamates;Goals;Health;hedonic;Hour;Human;improved;Incentives;Individual;Intravenous;Intravenous infusion procedures;Ketamine;Knowledge;Laboratories;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measurement;Measures;Mental Depression;Mental disorders;neural;neural circuit;NMDA receptor antagonist;nonhuman primate;Participant;Patient Self-Report;Peripheral;personalized medicine;Pharmaceutical Preparations;Placebos;Primates;Public Health;Randomized;response;Rest;reuptake;reward processing;Rewards;Role;Saline;Stimulus;Structure;Symptoms;Techniques;Therapeutic;Time;translational neuroscience;Work

PROJECT_TITLE: Neural Circuit-Specific Mechanisms of Ketamine's Effect on Anhedonia and Anxiety in Depression Using Ultra-High Field 7-Tesla MRI

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Nutrition

PHR: Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and Metabolism PROJECT NARRATIVE The transition metal copper (Cu), which is acquired as a dietary nutrient, contributes to the balance between cell proliferation and cell death that is essential for life. An emerging paradigm in nutrient sensing and protein regulation, termed metalloallostery, whereby protein activity is controlled by Cu at non-catalytic sites has expanded the contribution of Cu to signaling events and enabled therapeutic exploitation of Cu-dependent disease associated cellular processes. This proposal will build on this new and clinically relevant signaling paradigm by delineating molecular and cellular mechanisms that underlie Cu-dependent adaptations to nutrient scarcity that are critical for sustaining energy balance for survival under physiological conditions and in diseases settings.

PI_NAMEs: BRADY, DONITA C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Amino Acids;Applications Grants;Area;Autophagocytosis;Binding;Biogenesis;Biology;Carbohydrates;Cell Death;Cell Physiology;Cell Proliferation;clinically relevant;cofactor;Copper;detection of nutrient;Development;dietary;Disease;energy balance;Ensure;Enzymes;Equilibrium;Event;flexibility;Homeostasis;Knowledge;Life;lipid metabolism;Lipids;MAP2K1 gene;Mediating;Mediator;Metabolic;Metabolism;Mitochondria;Molecular;novel;Nutrient;Oxidation-Reduction;Oxygen;Phenotype;phosphoric diester hydrolase;Phosphotransferases;Physiological;Physiology;Protein Kinase;Proteins;Recycling;Regulation;Research;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Stress;Therapeutic;therapeutic target;Transition Elements


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE The Northwestern investigators patient-centered and priority and established integrate proposed Cardiovascular Research Training in Nigeria (CeRTIN) program is a collaboration between  University and University of Abuja in Nigeria. The program will build capacity among Nigerian  to lead multi-disciplinary cardiovascular implementation research studies, clinica trials, and  outcomes research studies across the lifespan that are aligned with national (Nigeria, NIH)  international (UN Sustainable Development Goals, WHO Best Buys for Noncommunicable Diseases)  areas. The program will leverage existing investments by the NIH at both institutions to foster timely  relevan research using a contemporary, adult-learning theory-based approach that will strengthen  collaborations between researchers at University of Abuja and Northwestern University and  into broader research networks.  l t

PI_NAMEs: HIRSCHHORN, LISA  (contact);HUFFMAN, MARK D;OJJI, DIKE BEVIS

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cessation of life;Clinical;Clinical Trials;Collaborations;Communities;Country;Data;Degree program;design;Disease;disorder control;disorder prevention;doctoral student;Educational Curriculum;Educational process of instructing;Educational workshop;evidence base;experience;Face;Faculty;Funding;Generations;Goals;Grant;implementation science;improved;Individual;Intervention;life span;Master of Science;Mentors;Mentorship;multidisciplinary;Nigeria;Nigerian;novel;Outcome;Outcomes Research;Participant;Patient-Centered Care;Patient-Focused Outcomes;Population;Postdoctoral Fellow;Prevention;primary care setting;programs;Public Health;Recommendation;Research;Research Methodology;Research Personnel;Research Training;skills;symposium;Teaching Hospitals;Training;Training Programs;United States National Institutes of Health;Universities

PROJECT_TITLE: Cardiovascular Research Training In Nigeria (CeRTIN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Although oxygenated lipids play critical roles in health and disease, the biological significance of many oxygenated lipid remains incomplete. This project presents an innovative basic research program to investigate the signaling machinery that regulates the synthesis and function of bioactive lipids. Deciphering the function of novel signaling lipids will provide valuable insight into the initiation and progression of a broad range of diseases.

PI_NAMEs: TOURDOT, BENJAMIN ERIC (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: 12-HETE;Address;Anabolism;Arachidonate 12-Lipoxygenase;Arachidonic Acids;Basic Science;Biological;Biological Models;Biological Process;Biology;Blood Platelets;Cardiovascular Diseases;Cells;Clinic;Clinical;clinically relevant;Coagulation Process;Consensus;Cytochrome P450;Detection;Disease;disease diagnosis;Genes;Goals;Health;Human;Individual;Inflammation;innovation;insight;Knowledge;lipidomics;Lipids;Lipoxygenase;Malignant Neoplasms;Megakaryocytes;Mixed Function Oxygenases;Modeling;nanomolar;novel;novel therapeutic intervention;Pattern;Play;Polyunsaturated Fatty Acids;Prognosis;programs;Prostaglandin-Endoperoxide Synthase;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;tool;Translations;tumor progression

PROJECT_TITLE: Mechanisms regulating the biosynthesis and signaling of oxylipins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Extremely high-throughput mapping of protein, RNA, and chromatin interactions in health and disease  Project narrative This project will develop extremely high-throughput technologies and companion bioinformatics tools for mapping diverse types of molecular interactions at the genomic scale. I will identify protein-protein, RNA-protein and RNA- chromatin changes at whole-genome scale in diabetes related vascular complications, specifically in hyperglycemia and chronic inflammation-induced irreversible alterations vascular endothelial cells. I anticipate that these technologies and their enabled discoveries will contribute to and inspire transformative changes in the study of Diabetes, Endocrinology, and Metabolic Diseases.

PI_NAMEs: ZHONG, SHENG  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Binding;bioinformatics tool;Blood Vessels;catalyst;cell type;Cells;Chromatin;Chronic;Companions;Diabetes Mellitus;diabetic ulcer;diabetic wound healing;Disease;DNA;Endocrinology;Endothelial Cells;endothelial dysfunction;Gene Expression;Genome Mappings;genome-wide;Genomics;Health;high throughput technology;Hyperglycemia;Inflammation;Maps;Metabolic Diseases;Molecular;molecular scale;Proteins;Research;RNA;Role;System;Technology;Time;Vascular Endothelial Cell;whole genome


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Antibody dependent cellular cytotoxicity (ADCC) partially protects exposed infants from acquiring neutralization-resistant HIV-1 from their chronically infected mothers and it decreases infected infant mortality. This proposal will investigate ADCC selection pressure during mother to child transmission and estimate ADCC impact on level of infected cells and inflammation in infected infants. We will identify the ADCC antibodies that influence mother to child transmission and characterize their properties, which may highlight novel avenues for future vaccine strategies.

PI_NAMEs: SAGAR, MANISH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Animal Model;Antibodies;Antibody Specificity;antibody-dependent cell cytotoxicity;antiretroviral therapy;Autologous;Birth;Blood;Breast Feeding;Cells;Characteristics;Chronic;Clinical Trials;cohort;Data;Epitopes;exposed human population;Exposure to;Future;Generations;Genetic Transcription;HIV;HIV-1;Human;Human Milk;Immunoglobulin Somatic Hypermutation;Immunologic Factors;Immunotherapy;improved;Individual;Infant;infant infection;Infant Mortality;Infection;Inflammation;inflammatory marker;Infusion procedures;insight;Integration Host Factors;Investigation;Maternal antibody;Mediating;Methodology;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mothers;neutralizing antibody;novel;passive antibodies;Plasma;Population;Predisposition;Pregnancy;pressure;prevent;Prevention trial;Property;Residual state;Resistance;resistant strain;response;RNA;Role;Sampling;Susceptibility Gene;synergism;T-Lymphocyte;Techniques;Testing;transmission blocking;transmission process;vaccine strategy;Vaccines;Variant;Vertical Disease Transmission;Viral;viral transmission;Viremia;Virus;virus characteristic;Work

PROJECT_TITLE: Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


ORG_NAME: SOUTHERN METHODIST UNIVERSITY

PHR: PROJECT NARRATIVE Quality control pathways that maintain the integrity of biological entities at different levels, including single molecules, complexes, and organelles, are important for the pathogenesis and pathophysiology of a wide range of human diseases. Little is known about whether and how these quality control pathways crosstalk with each other in response to pathological changes. This project is designed to characterize the interaction of different quality control pathways and understand how their defects contribute to disease pathogenesis.

PI_NAMEs: WU, ZHIHAO  (contact)

PROJECT_TERMS: Adopted;Animal Model;Biological;biological adaptation to stress;Biology;biomacromolecule;Cells;Cellular Stress;Communication;Complex;Defect;design;Development;Disease;Dissociation;Eukaryotic Cell;Functional disorder;Genome;Goals;human disease;Impairment;insight;Intervention;Knowledge;Link;Macromolecular Complexes;Messenger RNA;Methodology;Mitochondria;Mitochondrial Proteins;Molecular;Monitor;novel;Nuclear;Organelles;Pathogenesis;Pathologic;Pathway interactions;Peptides;Proteins;Quality Control;repaired;Research;response;Ribosomes;Role;Signal Pathway;single molecule;Stress;Structure;System;Tissues;Translations;unpublished works;Work

PROJECT_TITLE: Decipher the Organization of a Multilayered Cellular Quality Control Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]