NIH_SPENDING_CATS: Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The goal of our Program is to elucidate the molecular mechanisms by which human cytomegalovirus (HCMV) recruits and controls host DNA damage responses to ensure the fidelity of the viral genome. Importantly, this work will define the mechanisms by which HCMV evolves antiviral resistance. Despite advances in diagnostics and therapeutics, HCMV remains a major life-threatening complication following solid organ or stem cell transplantation.

PI_NAMEs: BOSCO, GIOVANNI ;GOODRUM, FELICIA D (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Anti-viral resistance;Anti-viral Therapy;antiviral nucleoside analog;Architecture;Biological Models;Biology;Bypass;Cells;Chemicals;Chromatin;Chromosome Fragile Sites;Complex;Complication;Cytomegalovirus;Data;Diagnostic;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;Double Stranded DNA Virus;Elements;Ensure;Event;Evolution;Family;FANCD2 protein;Ganciclovir;Genetic Recombination;Genome;genome integrity;Genome Stability;Genomic Instability;Goals;Guanine + Cytosine Composition;Hematopoietic;Herpesviridae;Human;Immunocompromised Host;Infection;inhibitor;insight;Integration Host Factors;knock-down;Lesion;Life;Life Cycle Stages;Mammalian Cell;Mediating;Molecular;novel;Nuclear;Nucleosides;Organ;Pathway interactions;Polymerase;Process;programs;Proteins;Publishing;reactivation from latency;recruit;Recruitment Activity;Repair Complex;repaired;Resistance;response;Risk;Role;Single Nucleotide Polymorphism;Single-Stranded DNA;Site;Solid;Stem cell transplant;Therapeutic;Transplant Recipients;ubiquitin isopeptidase;Viral;Viral Drug Resistance;Viral Genome;viral genomics;Viral Pathogenesis;Virus;virus host interaction;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Host DNA repair pathways in human cytomegalovirus replication

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: REDDY, RAVINDER  (contact)

PROJECT_TERMS: Advanced Technology Center;Basic Science;Biomedical Research;biomedical scientist;Clinical;Clinical Research;cloud storage;Communication;Communities;Computer software;Country;Dedications;Development;Disclosure;Educational workshop;Environment;Faculty;Goals;Human Resources;Imaging technology;improved;Individual;innovation;Knowledge;Learning;lectures;Legal patent;Manuals;meetings;member;metabolic imaging;next generation;Optics;Patient Care;Peer Review;precision medicine;programs;Publications;Radiology Specialty;Research;Research Personnel;Research Project Grants;Resources;Scientist;Series;skills;social media;Students;symposium;System;Technology;technology training;Training;Translations;Videoconferencing;web site

PROJECT_TITLE: CAMIPM-Tech-Training-Dissem


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Microbial communities relevant for human health are often dense, spatially structured, and interact both chemically and physically, for example by releasing toxins to prevent infection by external colonizing pathogens and building localized pressure to penetrate soft tissues. Our work will reveal the impact of mechanics and microbial antagonism on the evolutionary trajectories of microbial communities and will help us understand how spatial constraints impose selective pressures that lead to the increased invasiveness of microbial infections. By investigating the factors required for the successful replacement of a microbial strain by an invading antagonist, our results will help design better strategies for microbiome engineering and microbial replacement therapies.

PI_NAMEs: GIOMETTO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Evolutionary dynamics of dense, spatially structured, and antagonistic microbial populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Neuroinvasive herpesviruses are the causative agents of a number of severe diseases including encephalitis, shingles, neonatal infections, and keratitis. The goal of these studies it to develop a working understanding of the neuroinvasive properties of these viruses with the expectation that the research will lead to new resources in the continuing effort to develop antivirals, vaccines, and viral vectors for repair of in-borne genetic errors and treatment of nervous system associated cancers.

PI_NAMEs: SMITH, GREGORY ALLAN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Afferent Neurons;Alphaherpesvirinae;Anti-viral Agents;Axon;Axonal Transport;Binding;Binding Sites;Brain;Capsid;Cell Nucleus;Cells;Centrosome;Complex;design;Disease;DNA Viruses;Dynein ATPase;Encephalitis;expectation;Experimental Designs;Eye;Family;Family member;Gene Delivery;Genetic;Genome;Goals;Herpes zoster disease;Herpesviridae;Herpesvirus 1;Herpesvirus Type 3;Human Herpesvirus 2;human pathogen;Immunocompetent;Infection;Injections;Invaded;Keratitis;Kinesin;latent infection;mad itch virus;Malignant Neoplasms;Maps;member;Microtubules;Modeling;Morbidity - disease rate;mortality;Mothers;Motion;Motor;Mutation;neonatal infection;Nervous System;neural;Neuroglia;Neurons;Newborn Infant;Nuclear Pore;Oncolytic;pathogen;Pattern;Peripheral;Production;programs;Property;Proteins;recruit;repaired;Research;Resources;Role;Simplexvirus;Site;Structure;Synapses;Technology;tissue tropism;Tracer;trafficking;trait;Trauma;ubiquitin-protein ligase;Ubiquitination;Vaccines;Varicellovirus;vector;Viral;Viral Genome;Viral Vector;Virion;Virus;Virus Diseases

PROJECT_TITLE: ALPHA-HERPESVIRUS TRANSPORT IN AXONS

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Rare Diseases

ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Peroxisomes and lipid droplets (LDs) are organelles generated in the subdomains of the endoplasmic reticulum (ER) membrane. The proposed research seeks to characterize the ER subdomains using yeasts and mammalian cell culture to identify the proteins and lipids essential for the formation of nascent peroxisomes and LDs. This work will have implications for neurological disorders associated with peroxisome function as well as metabolic diseases of improper LD storage including lipodystrophy, fatty liver and type 2 diabetes.

PI_NAMEs: JOSHI, AMIT  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Binding;Biogenesis;C2 Domain;Cell Culture Techniques;Cells;Cellular biology;Defect;Disease;Endoplasmic Reticulum;Eukaryota;Eukaryotic Cell;Family;Fatty Liver;fatty liver disease;Functional disorder;Goals;Integral Membrane Protein;Intracellular Membranes;Life;Lipids;Lipodystrophy;Mammalian Cell;Medical;Membrane;Metabolic Diseases;Mitochondria;Morphology;Nervous System Disorder;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Envelope;Organelles;peroxisome;Play;Proteins;Research;Role;Saccharomyces cerevisiae;Testing;therapeutic target;Vesicle;Work;Yeasts;Zellweger Syndrome

PROJECT_TITLE: MECHANISMS OF ORGANELLE BIOGENESIS AT THE ENDOPLASMIC RETICULUM SUBDOMAINS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE Reduced positive affect is a core symptom of stress-related psychiatric disorders, including depression and PTSD, where incidence is higher among females, and current treatments are not as effective as they need to be. Recently, we demonstrated that real-world experiential diversity – exploring new, varied, and different places – predicts increased real-world positive affect, and that this relationship is supported by the strength of hippocampal-nucleus accumbens interactions–a stress susceptible circuit responsible for assigning reward value to novelty. This project will expand this finding in a large sample to define the mechanisms of the complex behavior of experiential diversity to test whether specific types of experiential diversity are most effective at driving affective change, identify the biological mechanisms supporting these effects, and determine whether experiential diversity causes changes in positive affect to improve treatment of anhedonia.

PI_NAMEs: HELLER, AARON S (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Affect;Affective;Age;Anhedonia;anti-depressive agents;Automobile Driving;avoidance behavior;Behavior;Biological;Brain;Businesses;Censuses;Chronic stress;Clinical;Clinical Trials;Complex;Data;Depressed mood;depressive symptoms;design;Dimensions;disability;Disease;effective intervention;Emotions;Ethnic Origin;Exercise;experience;Exploratory Behavior;Female;Functional Magnetic Resonance Imaging;Gender;Geography;Green space;Hippocampus;Human;improved;Incidence;Individual;Injections;Intervention;Link;Location;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Methods;mortality risk;negative affect;Neighborhoods;neural;neural circuit;neural network;neuroimaging;neuromechanism;Nucleus Accumbens;Oceans;Pathway interactions;Patients;Population Density;positive emotional state;Post-Traumatic Stress Disorders;pre-clinical;preclinical study;Predisposition;Property;Race;Recording of previous events;Recovery;Recreation;recruit;Rest;Restaurants;Rewards;Role;Sampling;Science;Severities;Social Interaction;sociodemographics;Stress;stress symptom;Suicide;Symptoms;Testing;therapy development;Travel;Treatment Efficacy;Treatment Failure;Unemployment;Variant;Visit;Work

PROJECT_TITLE: Mapping links between real-world diversity, positive emotion, and neural dynamics in anhedonia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: UROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Our goal is to elucidate the pathways through which county-level structural racism influences hypertension and its risk factors among 30,000+ Black and White participants in counties across the US from the REasons for Geographic and Racial Differences in Stroke (REGARDS) longitudinal cohort. Building on our research using our novel multi-domain measure of structural racism, this multilevel analysis will quantify the contribution of structural racism to hypertension risk factors, morbidity, and severity, and estimate hypertension healthcare costs that could be saved if structural racism was eliminated. This work will provide evidence for structural racism as a fundamental cause of persistent Black-White hypertension disparities and has the potential to impact policy decisions that can reduce hypertension disparities by addressing structural racism.

PI_NAMEs: DEAN, LORRAINE TIERA (contact);DOUGHERTY, GEOFFREY

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accounting;Address;Adult;Affect;African American;Alcohol consumption;American;Behavior;Behavioral;Biological Markers;Black American;Black Populations;Black race;Body mass index;C-reactive protein;cardiometabolism;Cardiovascular system;cationic antimicrobial protein CAP 37;Cholesterol;clinical epidemiology;cohort;cost;County;Criminal Justice;Cross-Sectional Studies;Data;Diet;Dimensions;Disparity;early onset;Education;Employment;Epidemiology;Equation;Exposure to;fasting glucose;Geography;Goals;Health;Health Care Costs;health care quality;health data;health disparity;health economics;Health Expenditures;Healthcare;high body mass index;Hospitals;Housing;Hypertension;Incidence;Individual;Inflammation;Inflammatory;Intervention;Journals;Leadership;Left;Life Cycle Stages;Link;Lipids;Longitudinal cohort;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Medicare claim;Modeling;Morbidity - disease rate;multilevel analysis;Myocardial Infarction;news;novel;Obesity;Observational Study;Paper;Participant;Pathway interactions;Physical activity;Physiological;Policies;Prevalence;Preventive Medicine;programs;Psychosocial Stress;Publications;Publishing;Race;racial disparity;racism;Reasons for Geographic And Racial Differences in Stroke;Renal function;Reporting;Research;Research Personnel;residential segregation;Resources;response;Risk Factors;Role;Severities;sex;social;social epidemiology;societal costs;Societies;Stress;stressor;Structural Racism;Tobacco use;Translating;Triglycerides;United States;waist circumference;Work

PROJECT_TITLE: Examining the Impact, Pathways, and Cost of County-Level Structural Racism on Hypertension Disparities in Black and White US Adults


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This proposal seeks to elucidate the immune-suppressive mechanism of FGL1, a novel LAG-3 functional ligand, on the regulation of T cell responses in the tumor microenvironment and explore its prognostic value in cancer immunotherapy. We will also characterize a series of new antibodies targeting LAG-3 that differentially block either or both FGL1/MHC-II ligands, both functionally and structurally, and explore better approaches targeting the LAG-3 pathway in the control of tumor immunity for clinical application. The successful completion of our proposed studies will provide important insights into FGL1/LAG-3 cancer immunobiology and suggest new approaches for next-generation cancer immunotherapies.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Ablation;Activated Lymphocyte;Affect;Affinity;Animal Model;anti-CTLA4;anti-PD-1;anti-PD-1/PD-L1;Antibodies;antigen-specific T cells;Binding;Binding Sites;Biochemical;Biological Assay;Biological Markers;Biological Products;Biology;Blocking Antibodies;Blood;Blood Circulation;cancer cell;cancer immunobiology;cancer immunotherapy;Cancer Patient;carcinogenesis;CD4 Positive T Lymphocytes;CD8B1 gene;checkpoint receptors;chemokine;Circulation;Clinical;clinical application;Clinical Trials;cohort;Cryoelectron Microscopy;cytokine;Data;design;Dose;Epitopes;experience;Fibrinogen;Fostering;Future;Genes;Genetic;genome-wide;Hepatocyte;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;Human;Hybridomas;Immune;immune cell checkpoints;immune checkpoint;immune checkpoint blockade;immune function;Immunity;Immunosuppression;Immunotherapy;In Vitro;in vivo;Individual;innovation;insight;Knowledge;KRAS oncogenesis;Lead;Licensing;Ligands;Liver;Lung Adenocarcinoma;Malignant Neoplasms;Maps;Mediating;Melanoma;Modeling;Monoclonal Antibodies;Mus;Mutation;next generation;Nivolumab;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel strategies;overexpression;Pathway interactions;patient biomarkers;patient response;patient stratification;Patients;PD-1/PD-L1;Phase II/III Trial;Plasma;predicting response;predictive marker;prognostic value;programmed cell death protein 1;programs;Proliferating;Protein Secretion;Proteins;receptor;Resistance;response;Role;Series;Shapes;Signal Transduction;System;T cell regulation;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Transplantation;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Tissue;tumor xenograft;Up-Regulation;X-Ray Crystallography

PROJECT_TITLE: Elucidating the Role of Cancer-Associated FGL1 in Tumor Immunity and Developing FGL1-Guided Anti-LAG-3 Cancer Immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative  There is an ongoing substance abuse epidemic in western society. Synthetic psychoactive agents are among the newest, most popular, and least understood of the abused substances. This work focuses on the development of a new platform to understand bath salts and related agents to define novel therapeutic targets to treat toxicity and episodic lethality.

PI_NAMEs: SCHIEFER, ISAAC T (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Adult;Adverse effects;Affinity;Affinity Chromatography;Alkynes;analog;Azides;bath salts;Behavioral;Behavioral Paradigm;behavioral response;Binding;Binding Proteins;Bioinformatics;Biological Assay;biological systems;Biology;Biotin;Brain;Cardiac Myocytes;cathinone;cell immortalization;Cell Line;Chemicals;Chemistry;Databases;design;Development;Disease;Drug Exposure;Drug Targeting;Drug toxicity;ecstasy;efficacy evaluation;Epidemic;experimental study;fluorophore;Funding;Future;Gel;Generations;Goals;Grant;Heart;Hepatic;HepG2;In Vitro;in vivo;innovation;insight;Internet;Investments;Kilogram;knock-down;Label;Lead;Learning;Libraries;Liver;Measures;Mediating;Mental Health;Modeling;Molecular;Molecular Target;monoamine;National Institute of Drug Abuse;neurobehavioral;Neurons;Neurotransmitters;new therapeutic target;novel;Pathway Analysis;Pathway interactions;PC12 Cells;Pharmaceutical Preparations;Phenethylamines;Phenotype;Photoaffinity Labels;Proteins;Proteomics;Psychotropic Drugs;Rattus;receptor;receptor binding;Research;Route;Sales;Side;Site;small molecule;Societies;Stable Isotope Labeling;stimulant abuse;Structure;Structure-Activity Relationship;Substance abuse problem;Synaptosomes;System;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;United States;uptake;Variant;Visit;Visualization;Work;Youth;Zebrafish

PROJECT_TITLE: Cross platform analysis of drug targets and toxicity of bath salts

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Somatosensory neurons innervating the tongue contribute to numerous perceptual qualities, including texture of food and location of gustatory stimuli. Understanding their role in normal function is the first step in determining how they might be repaired when disrupted (peripheral neuropathies and/or burning mouth syndrome).

PI_NAMEs: BREZA, JOSEPH MICHAEL;KRIMM, ROBIN FRANCES (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Afferent Neurons;Amyloid beta-Protein;Anatomy;Attention;awake;Behavior;Binding Proteins;Brain Stem;Burning Mouth Syndrome;C Fiber;Cell Nucleus;Central Nervous System;Characteristics;Code;Cream;Data;Electrophysiology (science);Epithelium;Esthesia;experience;experimental study;feeding;Fiber;Food;Fungiform Papilla;Gene Expression;Genes;Genetic;Genetic Identity;Genetic Markers;Goals;Housing;Image;Lateral;Light;Liquid substance;Location;mechanical stimulus;Mechanoreceptors;Mediating;Modality;Mucous Membrane;multimodality;multisensory;Mus;Nerve Growth Factor Receptors;nerve supply;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 3;olfactory stimulus;optogenetics;Oral;Oral cavity;oral sensory;Organ;Parvalbumins;Perception;Peripheral;Peripheral Nervous System Diseases;postsynaptic neurons;Potato;Property;Proprioceptor;receptive field;repaired;Research;response;Rodent;Role;Sensory;Skin;Smell Perception;somatosensory;Stimulus;Structure;Structure of trigeminal ganglion;Surface;Synapses;Taste Buds;Taste Perception;taste stimuli;Temperature;Testing;Texture;Thermoreceptors;Tongue;tongue papilla;tool;Touch sensation;Trigeminal Nuclei;Trigeminal System;Viral

PROJECT_TITLE: The fungiform papilla as a multi-sensory end-organ

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project will test whether metformin, a drug currently approved to treat diabetes, can be safely used to improve the response to antibiotic treatment of non-diabetic TB in patients with HIV. We predict that metformin will speed up the response to antibiotics and prevent lung damage that afflicts half of all patients who are cured of TB. Positive results from this clinical trial could change the way that TB is treated around the world.

PI_NAMEs: KORNFELD, HARDY  (contact);SINGHAL, AMIT ;WALLIS, ROBERT S

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;Address;adenylate kinase;Adoption;Adverse event;Aerosols;Anti-diabetic Drugs;Antibiotic Therapy;Antibiotics;antimicrobial;antiretroviral therapy;Antitubercular Agents;Autophagocytosis;Biological;Biological Assay;biosignature;Cause of Death;Cavia;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cells;Cessation of life;Clinical;Clinical Data;clinical research site;Clinical Trials;co-infection;cohort;Complement;cost;Data;Diabetes Mellitus;diabetic;double-blind placebo controlled trial;drug discovery;Drug Kinetics;Drug resistance;Future;gastrointestinal;gastrointestinal symptom;Gene Expression;Goals;Growth;HIV;HIV Infections;HIV/TB;Host Defense;Human;Immune;immune reconstitution;Immune response;Immunity;Immunologics;immunoregulation;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;inflammatory modulation;insight;Lung;lung injury;lung preservation;Macrophage;Measures;Mediating;Metabolic;Metformin;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Participant;pathogen;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase III trial;Placebo Control;pre-clinical;preclinical study;prevent;primary endpoint;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Tuberculosis;Quality of life;Questionnaires;radiological imaging;Randomized;Regimen;respiratory;respiratory health;response;Risk;Safety;Sampling;secondary endpoint;Severities;Signal Pathway;Signal Transduction;South Africa;Speed;Sputum;standard care;Sterilization;Symptoms;Syndrome;T cell response;T memory cell;Testing;Therapy trial;Time;Toxic effect;transcriptomics;Treatment Efficacy;trial design;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Viral Load result;Vulnerable Populations;Whole Blood

PROJECT_TITLE: Trial of Metformin for TB/HIV Host-directed Therapy


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative  Chlamydia species are obligate intracellular bacteria that are leading causes of ocular, genital, and respiratory infections in humans. This grant seeks to understand how Chlamydia survives within the hostile intracellular environment.

PI_NAMEs: ENGEL, JOANNE N. (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affinity;Affinity Chromatography;Animal Model;Antibiotics;Bacteria;Binding;Biochemistry;Biological Assay;Biology;Cell membrane;Cells;cellubrevin;Cellular biology;Chlamydia;Chlamydia trachomatis;Complex;cost effective;Data;Data Set;Defect;Developing Countries;Disease;Early Endosome;Endosomes;Environment;Epitopes;experimental study;Eye Infections;Family;Genetic;genital infection;Grant;Human;human disease;In Vitro;induced pluripotent stem cell;Infection;insight;Knowledge;late endosome;Life Cycle Stages;Lipids;Liposomes;live cell microscopy;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Microbe;Microscopy;Mining;Modeling;Molecular;mouse model;Multiprotein Complexes;multitask;mutant;novel;obligate intracellular parasite;Organelles;pathogen;Pathogenesis;Pathway interactions;peptidomimetics;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;Process;Production;protein complex;protein function;protein purification;protein transport;Proteins;Recurrence;reproductive tract;Respiratory Tract Infections;RNA Interference;Role;scaffold;Scaffolding Protein;SNAP receptor;sorting nexins;Structure;syntaxin;Testing;trafficking;Transfection;Type III Secretion System Pathway;Vaccines;Variant;Vesicle;Virulence

PROJECT_TITLE: Dissecting the role of the Inclusion membrane protein IncE, a master multi-tasking scaffolding protein, in the pathogenesis of Chlamydia trachomatis infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-W(80)]


ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Age-related hearing loss is one of the most common conditions in the elderly. Many genetic factors causing hearing loss have been identified, but many more remain to be identified; and our lack of knowledge about the mechanisms by which they cause hearing loss is a barrier that must be overcome if we are to develop methods for preventing (or reversing) age-related hearing loss. This project will develop computational tools that will greatly accelerate the pace of genetic discovery for hearing loss and will characterize the mechanism by which genetic factors cause spontaneous hearing loss in multiple inbred mouse strains.

PI_NAMEs: PELTZ, GARY A (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Ablation;Acceleration;Alleles;Artificial Intelligence enhanced;Auditory;Auditory system;Candidate Disease Gene;candidate identification;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;computational pipelines;computerized tools;Data;Databases;DNA Sequence Alteration;Ear;Elderly;Engineering;Environment;Evaluation;Exons;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic effector;genetic variant;Genome;Genome engineering;genome wide association study;Genomics;Goals;Health;hearing impairment;Homologous Gene;Human;Human Genetics;improved;Inbred Strain;Inbred Strains Mice;Individual;interest;Knock-in;Knock-in Mouse;Knock-out;Knowledge;Laboratory mice;Methods;model organism;Modeling;Morphology;mouse genetics;mouse genome;mouse model;Mus;Mutation;Noise-Induced Hearing Loss;novel;Phenotype;Presbycusis;prevent;Probability;Resources;Series;Shapes;Stretching;trait;Variant

PROJECT_TITLE: AI-based genetic discovery for hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Infectious Diseases;Lung;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: People with HIV (PWH) are facing increased morbidity and mortality due to non-infectious heart, lung, blood, and sleep (HLBS) disorders with many unanswered questions in the current era including the role of emerging risk factors such as COVID-19, newer antiretroviral therapy (ART) medications, non-traditional risk factors such as social determinants of health, and the increasingly complex interactions of HLBS conditions with each other. This proposal builds on the large, diverse CNICS cohort of PWH with comprehensive clinical data, specimens, and sociobehavioral measures to study understudied important HLBS conditions such as obstructive sleep apnea, as well as to study evolving risk factors for other conditions such as myocardial infarction, stroke, atrial fibrillation, and venous thromboembolism. New and timely knowledge about the increasing complexity of HLBS conditions among PWH including screening, risk factors, and complex interactions of HLBS conditions with each other and other syndemic conditions will inform clinical decision-making and improve understanding of the mechanisms that increase the frequency of HLBS diseases and risk of poor outcomes in PWH in current clinical care.

PI_NAMEs: CRANE, HEIDI M. (contact);CROTHERS, KRISTINA ANNE;DELANEY, JOSEPH AUSTIN

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Address;adjudication;Admission activity;Affect;Aging;aging population;Alcohol consumption;Anemia;antiretroviral therapy;Atrial Fibrillation;behavior measurement;Behavioral;Blood;Cardiovascular Diseases;care outcomes;Caring;Cessation of life;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;Clinical Data;clinical decision-making;clinically relevant;Coagulation Process;cocaine use;cohort;Cohort Studies;Communities;Complex;COVID-19;COVID-19 complications;Development;Diabetes Mellitus;Disease;Early treatment;Environmental Risk Factor;Event;experience;Frequencies;Funding;gender diverse;Grant;Heart;Heart Diseases;Hematological Disease;High Prevalence;high risk;HIV;Home;Homelessness;Hospitalization;Housing;housing instability;Hypertension;Imprisonment;improved;Incidence;Individual;Inflammatory;inflammatory marker;instrument;interest;Intubation;Knowledge;lifestyle factors;Link;Lung;Lung Diseases;machine learning model;marginalization;Mental Depression;monocyte;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;Obstructive Sleep Apnea;Outcome;Oxygen;Pathway interactions;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Physical activity;Population;Poverty;Prevalence;Protocols documentation;racial diversity;Regimen;Resources;Risk;Risk Factors;Role;rurality;SARS-CoV-2 infection;screening;Screening procedure;Sepsis;Severities;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Social Behavior;social factors;social health determinants;Social Interaction;social stigma;Social support;socioeconomics;Specimen;Standardization;Stroke;Structural Models;substance use;syndemic;System;targeted treatment;Testing;thrombotic complications;transgender women;vaping;venous thromboembolism;Viremia;Work

PROJECT_TITLE: Links between Cardiovascular disease, Lung disease, and Obstructive sleep apnea in HIV: Understanding complex patients

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Basic science, translational, and clinical research in Otolaryngology – Head and Neck Surgery is making remarkable advances that affect the way we treat patients. Herein, we propose to implement a research training program designed to cultivate clinician-scientists. The ultimate long-term goal of this program is to train the next generation of clinician-scientists who will improve human health by combining scientific discovery with clinical care.

PI_NAMEs: OGHALAI, JOHN S (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Advisory Committees;Affect;Applications Grants;Attitude;Basic Science;bench to bedside;Benchmarking;Board Certification;California;career;Career Choice;Categories;Charge;Clinical;clinical care;Clinical Research;clinical translation;cohort;Data;Dedications;design;Development;Disease;educational atmosphere;Educational process of instructing;equity, diversity, and inclusion;Ethnic Population;Evaluation;experience;Extramural Activities;Faculty;faculty mentor;Feedback;Fellowship;Functional disorder;Funding;Future Generations;Goals;Grant;Head and Neck Surgery;Health;Health Benefit;Human;Human Biology;human disease;improved;Individual;Institution;interest;Journals;Knowledge;Life;Manuscripts;Measures;Medical Students;Medicine;member;Mentors;Mentorship;Methodology;Monitor;next generation;Nursing Faculty;Otolaryngology;Patient Care;Patients;Performance;Persons;Philosophy;Positioning Attribute;Process;programs;Publications;racial population;recruit;Research;Research Activity;Research Personnel;Research Proposals;Research Training;Residencies;Resources;Scientist;Secure;Series;Speed;Structure;success;Surgeon;Surveys;Time;Tissue Sample;tool;Training;Training Programs;Translating;translational approach;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Writing

PROJECT_TITLE: Otolaryngology Clinician-Scientist Training Program


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Data Science;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Exposure to outdoor air pollution is a risk factor for “accelerated” aging and Alzheimer’s disease, but very few studies have used neuroimaging to define the mechanistic underpinnings of these relationships. This proposal will address this gap through a new environmental working group within the ENIGMA consortium. This will be the first international study to assess how AP 1) affects the structural integrity of the CAN in older adults across geographically diverse datasets, 2) interacts with biopsychosocial factors to influence heterogeneity in AD risk within the aging brain, and 3) influences brain integrity across the life course.

PI_NAMEs: SALMINEN, LAUREN E. (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Address;Adolescence;Adverse effects;Affect;Age;age acceleration;age effect;age related;Aging;aging brain;Air;Air Pollution;Alzheimer's Disease;Alzheimer's disease risk;ambient air pollution;Ammonium;Anisotropy;apolipoprotein E-4;Architecture;Area;Biological;biological adaptation to stress;biopsychosocial factor;Brain;brain abnormalities;brain health;Brain Injuries;Brain region;brain shape;Brain Stem;Carbon Black;Chemicals;Child;Chronic;Circulation;cohort;Country;data harmonization;Data Science;Data Set;design;Detection;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Distress;diverse data;Dust;Environment;Epidemiology;Exposure to;fine particles;Genetic;Genotype;Geography;gray matter;Health;Heterogeneity;high dimensionality;Hippocampus;immune function;Income;Individual;Infrastructure;Insula of Reil;International;Investigation;Knowledge;large scale data;Life;Life Cycle Stages;life span;Literature;Machine Learning;Magnetic Resonance Imaging;Maps;Meta-Analysis;Methods;Modeling;Morphology;multidisciplinary;Nerve Degeneration;neuroimaging;neuroinflammation;Neurosciences;neurotoxic;neurotoxicity;Nitrates;Nitrogen Dioxide;older adult;Outcome;Oxidative Stress;Participant;Pathologic;Pathway interactions;Pattern;pollutant;Population;pre-clinical;Predisposition;Psyche structure;Radial;Reflex action;Reproducibility;Research;Respiration;response;Risk;Risk Factors;Sampling;Sea;sex;Sodium Chloride;Statistical Models;stressor;Structure;Sulfate;Surface;System;Thick;Training;white matter;working group

PROJECT_TITLE: Worldwide Mapping of Air Pollution Exposure Patterns on Aging Brain Health

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE TSCORE LIFT will create a community linkage among 5 health systems, 5 universities, and 5 school districts to develop and test a series of 3 educational interventions along the Kansas Health and Biosciences Career Pathway. The community linkages will empower 25 teacher partners to deliver educational content and real life experiences in the health care industry for 1,400 students. This novel health and bioscience program will create educational and workforce pathways for students underrepresented in the health care industry and address critical workforce shortages in the state in the immediate future.

PI_NAMEs: ALONSO LUACES, MARIA  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Active Learning;Address;Award;Biological Sciences;Biology;Biomedical Research;career;Career Choice;Career Exploration;Collaborations;Communities;Community Networks;community partnership;community-centered;design;Development;Diverse Workforce;Education;education access;Educational Curriculum;Educational Intervention;Educational process of instructing;empowerment;Ethnic Origin;experience;Faculty;Future;Geography;Grant;Health;Health Care Sector;health disparity;Health Sciences;Health system;Healthcare;Healthcare Industry;high school;High School Faculty;High School Student;higher education;improved;Industry;industry partner;Inequity;innovation;interest;Intervention;Kansas;Knowledge;Learning;learning materials;Life Experience;Lifting;Link;member;Mind;Minority;Modeling;novel;Pathway interactions;peer coaching;Persons;Population;Population Heterogeneity;programs;Race;real world application;Research;Resources;Rural;school district;School Teachers;Schools;Science;science education;Series;Site;skills;sociodemographics;Structure;Students;summer program;symposium;System;teacher;teacher community;Testing;Training;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;virtual;Work;workforce needs;Workplace

PROJECT_TITLE: Teachers and Students for Community-Oriented Research and Education:  Linking Industry Partners, Faculty, and Teachers (TSCORE LIFT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: BROOKLYN

ORG_DEPT: PSYCHIATRY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: This project will address important challenges of understanding deficits in structural and functional brain networks underlying the transition from regular drinking to Alcohol Use Disorder (AUD) by investigating multidomain measures of brain function—structural/density-weighted/functional Magnetic Resonance Imaging (s/d/fMRI) longitudinal electrophysiological (EEG, Event Related Potential/Oscillation (ERP/ERO)) and neurocognitive data in a genetically informative enriched high risk diverse adolescent and young adult prospective study sample, now entering the understudied age of emerging adulthood to midlife. With the use of novel analytic methods to leverage this unique high risk longitudinal multimodal dataset, with data from before and after the initiation of drinking behaviors, this study will elucidate reciprocal relationships among genomic and other risk/protective factors (e.g., COVID-19 related traumatic stress), sex differences and the role of vulnerabilities in neural circuits in the transitions to AUD with utility in prevention and treatment initiatives.

PI_NAMEs: KAMARAJAN, CHELLA ;MEYERS, JACQUELYN LEIGH;PANDEY, ASHWINI K;PORJESZ, BERNICE  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Adolescent and Young Adult;Adult Children;Affect;Affective;Age;age effect;Alcohol consumption;alcohol risk;alcohol use disorder;alcohol use initiation;analytical method;Anatomy;Anisotropy;Behavior;binge drinking;Brain;brain volume;Cannabis;career;cingulate cortex;Clinical Data;Cognitive;cognitive task;comorbidity;Complement;Corpus striatum structure;COVID-19;COVID-19 pandemic;COVID-19 stress;COVID-19 susceptibility;Data;Data Collection;density;Development;developmental disease;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;disorder risk;drinking;drinking behavior;DSM-V;Electroencephalography;Electrophysiology (science);emerging adulthood;Emotional;Epidemic;Ethnic Origin;Event-Related Potentials;executive function;Exhibits;Family;Family history of;Fiber;Functional impairment;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Gambling;Genetic;genetics of alcoholism;genome wide association study;Genomics;high risk;high risk drinking;high risk population;Hippocampus;Impairment;Individual;Inferior frontal gyrus;Insula of Reil;Joints;life span;Literature;Machine Learning;machine learning method;Measures;Mental Depression;Mental disorders;Methods;middle age;Modeling;multimodal data;multimodality;neural;neural circuit;neural network;neuroadaptation;Neurocognitive;neurogenomics;Neuropsychology;Nicotine;novel;Nucleus Accumbens;offspring;Pattern;polygenic risk score;Prevention;prospective;Prospective Studies;protective factors;Protocols documentation;Race;Recording of previous events;Recovery;resilience;response;Rest;reward processing;Rewards;Risk;Risk Factors;Role;Sampling;Sampling Studies;serial imaging;sex;Sex Differences;Social Environment;Specificity;substance use;temporal measurement;Thick;Time;trait;traumatic stress;white matter;Work;young adult

PROJECT_TITLE: Brain Function and Neurogenomic influences on AUD risk and resilience.

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative It is poorly understood how Tregs are affected by tumor metabolism in the tumor microenvironment. We will explore the molecular mechanisms of Treg apoptosis, energy circuits, and the metabolism-associated suppressive mode of action of Tregs. The proposal will provide an opportunity to take our understanding of Treg biology in the tumor to a new level of mechanism and application.

PI_NAMEs: ZOU, WEIPING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Active Immunization;Address;Adenosine;Affect;Antigen-Presenting Cells;antigen-specific T cells;Apoptosis;Apoptotic;Behavior;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Cell Communication;Cell Physiology;Cells;Cellular biology;checkpoint therapy;Clinical;clinical predictors;Clinical Research;Colon Carcinoma;Data;Dendritic Cells;design;Development;disease model;effector T cell;empowerment;Exhibits;Family;FOXP3 gene;Glucose;Glycolysis;Homeostasis;Human;Immune;Immune response;Immunity;immunogenicity;Immunosuppression;Immunotherapy;Impairment;improved;Ligands;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;MC38;Mediating;Melanoma;Memory;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Monoclonal Antibodies;Mus;Myelogenous;Myeloid Cells;Nature;Necrosis;novel;Nutrient;Oxidative Stress;oxidized lipid;Oxygen;Pathway interactions;PD-L1 blockade;Phagocytosis;Phenotype;potassium ion;practical application;Procollagen-Proline Dioxygenase;Production;programmed cell death ligand 1;Proteins;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;response;Signal Transduction;stem;success;Surface;T memory cell;T-Cell Activation;T-Lymphocyte;Technology;Testing;trafficking;Translational Research;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;Warburg Effect;Work;Zinc

PROJECT_TITLE: Regulatory T cells in cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The US Food and Drug Administration is considering reducing nicotine levels in cigarettes so that they are nonaddictive, which could have long-term implications for vulnerable populations that are disproportionately harmed by smoking. This study will use simulation modeling methods to conduct health and economic impact analysis of a reduced nicotine cigarette policy for two vulnerable populations; people with major depression and socioeconomically disadvantaged women of reproductive age. The policy will furthermore be assessed in the context of e-cigarette use and a potential illicit market for normal nicotine cigarettes.

PI_NAMEs: TAM, JAMIE PEARL (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Adult;Adverse effects;Affect;Age;Award;Behavioral;behavioral economics;behavioral health;behavioral pharmacology;behavioral response;career;Caring;Cessation of life;Cigarette;cigarette smoking;Clinical Trials;cost;Cost Effectiveness Analysis;Cost Savings;Data;disability;disadvantaged women;Drug usage;economic cost;economic evaluation;economic impact;Economic Models;economic outcome;Educational Status;Electronic cigarette;electronic cigarette use;Enrollment;Environment;Funding;General Population;Health;Health Benefit;Health Care Costs;Health Expenditures;Infant Health;Infant Mortality;Lead;Low Birth Weight Infant;low nicotine content cigarette;Major Depressive Disorder;Marketing;Maternal Health;Medical;Medical Care Costs;Medicine;member;Mental Depression;Mental Health;Mentors;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;National Health Interview Survey;Neurobiology;Nicotine;Nicotine Dependence;Outcome;Persons;Policies;Population;Pregnancy;Pregnant Women;premature;Premature Birth;Productivity;productivity loss;programs;Public Health;Regulation;reproductive;Reproductive Health;Research;Research Personnel;response;Risk;Risk Factors;Science;Scientist;Secure;skills;Small for Gestational Age Infant;Smoke;Smoker;Smoking;smoking cessation;smoking during pregnancy;smoking initiation;smoking-related disease;social factors;societal costs;Societies;socioeconomic disadvantage;Socioeconomic Status;success;Sudden infant death syndrome;Surveys;Tobacco;tobacco regulatory science;Training;United States Food and Drug Administration;United States National Institutes of Health;Vulnerable Populations;Woman

PROJECT_TITLE: Health and economic impact analysis of a reduced nicotine cigarette policy on vulnerable populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative The CEBH Training Program will continue to provide in-depth and interdisciplinary training in the hearing sciences that prepares individuals to advance discovery and innovation at the interface of basic science and medicine. More complete knowledge of auditory system function promises both to solve some of the most perplexing and devastating problems of human health, and to design pioneering methodologies, systems, and devices that will transform how we live.

PI_NAMEs: CARR, CATHERINE EMILY;GOUPELL, MATTHEW J. (contact)

PROJECT_TERMS: Biology;comparative;Hearing

PROJECT_TITLE: Comparative and Evolutionary Biology of Hearing


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Vaccines are urgently needed to prevent genital herpes and treat people already infected. We developed an nucleoside-modified mRNA vaccine candidate to prevent genital herpes that will enter phase 1 human trials in December 2022. In this renewal application, we propose using serum samples from mice and guinea pigs collected during the prior grant cycle to define the immune correlates of protection for the prevention vaccine, and to immunize mice and guinea pigs with nucleoside-modified mRNA antigens to develop a vaccine for treating genital herpes.

PI_NAMEs: FRIEDMAN, HARVEY MICHAEL (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acyclovir;Address;Affect;Animal Model;Anti-viral Agents;Anti-viral Therapy;Antibodies;Antibody Response;antibody test;antibody-dependent cell cytotoxicity;Antigens;Binding;Biological Assay;Biosensor;Blocking Antibodies;Capsid;Cavia;CD8-Positive T-Lymphocytes;Cells;Clinical;Complement;Complement 3b;Complement Activation;Complex;detection assay;Disease Outbreaks;DNA;efficacy study;Encapsulated;Epitope Mapping;Epitopes;experimental study;Failure;Fc domain;Female;Frequencies;Funding;Future;GD2 Binding;genital herpes;Genitalia;Glycoproteins;Goals;Grant;Herpesvirus 1;Herpesvirus Type 3;high standard;HSV glycoprotein C;Human;Human Herpesvirus 2;Immune;Immune Evasion;Immune response;Immunization;Immunize;Immunocompromised Host;Immunoglobulin G;Immunotherapy;Individual;Infection;Infection prevention;inhibiting antibody;interest;latent infection;Lesion;lipid nanoparticle;male;Measures;Mediating;Messenger RNA;Monoclonal Antibodies;mouse model;mRNA lipid nano particle vaccine;Mus;Nucleosides;Outcome;Persons;Phase;phase I trial;pre-clinical;prevent;Prevention;Preventive vaccine;primary endpoint;prophylactic;Receptor Cell;Recurrence;resistance mutation;response;Risk;Risk Marker;RNA vaccine;Sampling;Schedule;Serum;Site;success;T cell response;Technology;Therapeutic Studies;therapeutic vaccine;therapeutically effective;transmission process;vaccine candidate;vaccine development;vaccine efficacy;vaccine formulation;Vaccine Production;vaccine-induced immunity;Vaccines;valacyclovir;Viral Physiology;Virus;Virus Receptors

PROJECT_TITLE: Nucleoside-modified mRNA vaccine for prevention and treatment of genital herpes

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Aging;Bioengineering;Breast Cancer;Cancer;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Theobjective of this proposal is toprovide novel statistical models that can incorporate patient heterogeneity in a personalized, dynamic manner leading to a more accurate risk prediction scheme. The proposed project, although motivated by, but not limited to, breast cancer, willbe applicable to a broad range of applications from preventionto treatment and survivorship.

PI_NAMEs: JIANG, SHU  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Algorithms;Area;Breast Cancer Risk Factor;Cancer Burden;Cancer Control;cancer diagnosis;cancer risk;Chronic;Chronic Kidney Failure;Classification;Code;Computer software;Coronary heart disease;Data;Disease;Evaluation;Eye diseases;Future;Genomics;Health;Heterogeneity;Hormone use;improved;Individual;innovation;Life;Life Cycle Stages;Lifting;Malignant Breast Neoplasm;Mammography;Measures;Methodology;Methods;Modeling;novel;Nurses' Health Study;Obesity;Oncology;open source;Outcome;Patients;Pattern;Performance;personalized risk prediction;Population;Population Sciences;Positioning Attribute;Postmenopause;precision oncology;predictive modeling;Premenopause;Prevention;Principal Component Analysis;Prognosis;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction;risk prediction model;ROC Curve;Scheme;simulation;Statistical Models;survivorship;Time;tool;trend;Update;user-friendly;Validation;women's diagnosis;Work

PROJECT_TITLE: Dynamic prediction incorporating time-varying covariates for the onset of breast cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE The direct care workforce – which includes personal care aides, nursing assistants, and home health aides – is the largest occupation serving people living with dementia, but there is little research to guide evaluation and refinement of workforce-related policies and programs that affect their supply, demand, training, skills, and collaboration with other healthcare professionals. The AWARD Network will offer programs and activities to create a strong community of researchers engaged in research on the direct care workforce and its role in care for people living with dementia.

PI_NAMEs: SPETZ, JOANNE E. (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Assisted Living Facilities;care systems;career;Caring;Collaborations;college;Communities;community living;community setting;comparative;Data;Data Set;Dementia;dementia care;Discipline;Discipline of Nursing;Economics;Educational workshop;Employment;Ensure;Evaluation;evidence base;Family;Friends;Funding;Growth;health care service organization;health disparity populations;Health Professional;Healthcare;Home Health Agency;Home Health Aides;Household;Infrastructure;Institution;Interdisciplinary Study;Internships;Investigation;Measurement;Medicine;meetings;Mentors;Neurodegenerative Disorders;Nurses;Nursing Homes;Occupations;Outcome;Participant;payment;Persons;Play;Policies;Population Heterogeneity;programs;Public Health;Reduce health disparities;Regulation;Research;Research Personnel;Research Support;Residential Treatment;Resources;Role;Safety;Self Care;Services;Skilled Nursing Facilities;skills;Social Workers;Sociology;Speed;Stage Grouping;statistics;System;theories;Training;Underrepresented Populations;United States;virtual;Wages;webinar;Work

PROJECT_TITLE: Advancing Workforce Analysis and Research for Dementia (AWARD) Network


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Nearly 30% of people recovering from critical illness experience respiratory infections, tracheobronchitis, while weaning from the mechanical ventilator. Despite how common these infections are, we do not understand the long-term impact on recovery, why some people are more susceptible to the infections, or the airway bacterial dynamics during infection. Understanding the natural history and host-pathogen biology of tracheobronchitis during chronic critical illness will improve our ability to develop better diagnostics and more personalized treatments for tracheobronchitis.

PI_NAMEs: ZEMKE, ANNA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;acute care;Admission activity;airway inflammation;American;Antibiotic Resistance;Antibiotics;aspirate;Bacteria;Bacterial Infections;Biology;Blood;Carbon;Chronic;Clinical;clinical predictors;Cluster Analysis;cohort;Critical Illness;cytokine;Data;Data Set;Development;Diagnosis;Diagnostic;Elements;emerging pathogen;Environment;Event;Excision;experience;Financial cost;Functional disorder;Future;Goals;Growth;health care service utilization;Healthcare Systems;hospital care;Host Defense;improved;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Intervention;Intervention Studies;Invaded;Kinetics;Knowledge;Longitudinal cohort;Measurement;Measures;Metagenomics;Metals;microbiome;Micronutrients;Modeling;mortality;Mucosal Immunity;Mucous Membrane;Mutation;Natural History;Nested Case-Control Study;Nutrient;Nutritional;Organism;Outcome;Participant;pathogen;pathogenic bacteria;Pathogenicity;Patients;personalized medicine;Persons;Phase;Phenotype;Pneumonia;Population;Predisposition;primary outcome;Public Health;Quality of life;radiological imaging;Recovery;Registries;Research Infrastructure;respiratory;Respiratory Tract Infections;respiratory virus;Risk;secondary outcome;Shotgun Sequencing;Source;Sputum;Symptoms;systemic inflammatory response;Testing;Time;Trachea;Tracheostomy procedure;Ventilator;Ventilator Weaning;Virus Diseases

PROJECT_TITLE: Tracheobronchitis in the Critically Ill

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: We propose studies of methods for activating and controlling the functions of a class of specialized lymphocytes known as invariant Natural Killer T (iNKT) cells. The proposed work is strongly focused on understanding the signals that regulate immune responses by these cells, with the overarching goal of developing new approaches for immunotherapy of cancer.

PI_NAMEs: PORCELLI, STEVEN A (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acceleration;adaptive immune response;Address;alpha-galactosylceramide;anergy;anti-CTLA4;anti-PD-L1 antibodies;anti-tumor agent;anti-tumor immune response;Antibodies;anticancer activity;Antigen Presentation;Antigens;antitumor effect;Area;Attention;Biological;Biology;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;CD276 gene;Cell Culture Techniques;cell type;Cells;Cellular biology;Cellular immunotherapy;clinical development;clinical translation;Clinical Trials;clinically relevant;Complex;cost;CTLA4 blockade;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;design;Development;Engineering;Exposure to;Funding;Galactosylceramides;Glycolipids;Goals;Grant;Half-Life;Human;human model;humanized mouse;immune checkpoint;immune checkpoint blockade;Immune response;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;improved;in vivo;in vivo evaluation;Innate Immune Response;Ligands;Lipids;Lymphocyte;Malignant Neoplasms;Methods;MHC Class I Genes;migration;Modality;Modeling;mouse model;Movement;Mus;neoplasm immunotherapy;novel;novel strategies;Outcome;Phase;pre-clinical;Production;programmed cell death protein 1;Proliferating;Protein Engineering;Proteins;Publishing;Regimen;Role;Scaffolding Protein;screening;Signal Transduction;Solubility;Structure;success;synergism;Synthesis Chemistry;T cell anergy;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Toxic effect;translational study;tumor;VTCN1 gene;Work

PROJECT_TITLE: Precision Targeting of CD1-Restricted iNKT Cells for Cancer Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative.  We will identify the global transcriptional network, which is utilized by pulmonary microvascular endothelial cells to regulate lung remodeling and fibrogenesis. Focusing on FOXF1, a key endothelial anti-fibrotic transcription factor, we will determine novel molecular mechanisms through which FOXF1 inhibits the re- programming of normal endothelial cells into fibrosis-associated endothelial cells. We will test the efficacy of nanoparticle based FOXF1 gene therapy to treat lung fibrosis in mouse models. The outcomes from proposed studies are expected to have a positive impact on the development of new therapies for IPF patients.

PI_NAMEs: KALIN, TANYA  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Attention;Bleomycin;Blood capillaries;Blood Vessels;Breast;Cell Reprogramming;Cell Survival;cell type;Cells;Chest;Chronic;Chronic Lung Injury;Collagen;Data;Deposition;Development;Disease;DNA;efficacy testing;Endothelial Cells;endothelial dysfunction;Endothelium;Epithelial Cells;epithelial injury;Epithelium;Family;FDA approved;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;FOXF1 gene;gene therapy;Genes;Genetic;Genetic Transcription;Goals;Hepatocyte;Human;Hypoxia;idiopathic pulmonary fibrosis;Immune;improved;Inflammation;Inflammation Mediators;Inflammatory;injured;Injury;innovation;Interstitial Lung Diseases;irradiation;Kidney;Lung;Lung fibrogenesis;lung injury;lung microvascular endothelial cells;lung repair;Macrophage;Mediator;Modeling;Molecular;mouse model;Mus;Myofibroblast;nanoparticle;nanoparticle delivery;nintedanib;novel;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Outcome;overexpression;paracrine;Pathogenesis;Pathologic Neovascularization;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pirfenidone;Play;prevent;Process;programs;promoter;Pulmonary Fibrosis;Pulmonary Inflammation;recruit;Regulation;repaired;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;System;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;vascular injury;Vascular remodeling;vector

PROJECT_TITLE: Role of lung endothelial cells during fibrotic lung remodeling

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Relevance to Public Health By defining the mechanisms of PALB2 and the BRCA1-PALB2-BRCA2 pathway in the DNA damage response and tumor suppression, this study will advance our understanding of hereditary breast cancer development and tumor cell vulnerabilities. Results from this study may inform the rational design of novel approaches for the prevention and better treatment of the cancers. Insights from this study may also apply to other, hereditary or sporadic cancers associated with DNA damage, and therefore have broader implications.

PI_NAMEs: XIA, BING  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Alleles;Behavior;Binding;BRCA1 gene;BRCA2 gene;BRCA3 gene;Breast;Breast Cancer Risk Factor;Breast Epithelial Cells;cancer cell;cancer risk;cancer therapy;Cell Cycle;Cell Cycle Checkpoint;Cell division;Cell Proliferation;Cell Survival;Cells;Chromatin;Chromosomes;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Defect;Development;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Event;Fanconi's Anemia;Female Breast Carcinoma;follow-up;Genes;Genetic;Genetic Counseling;Genome Stability;Genomic Instability;Germ Lines;Germ-Line Mutation;Hereditary Breast Carcinoma;homologous recombination;Human;In Vitro;in vivo;Inherited;innovation;insight;Knock-in;Knock-out;Learning;lifetime risk;Link;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;malignant stomach neoplasm;Mammary gland;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;Modeling;Molecular;Morphogenesis;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;neoplastic cell;novel strategies;Oncogenes;Oncogenic;Organoids;Ovarian;PALB2 gene;Pancreas;Pathway interactions;phosphoproteomics;Phosphorylation;Play;PLK1 gene;Population Study;precision genetics;precision medicine;prevent;Prevention approach;Process;Prognosis;Proliferating;Prostate;protein function;Proteins;Proteomics;Public Health;RAD52 gene;rational design;recruit;repaired;Residual state;response;Role;Testing;Time;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Role of PALB2 in the DNA Damage Response and Cancer Suppression

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: NARRATIVE Skeletal muscle is unusual in that the functional cell (the contractile myofiber) is formed by fusion of hundreds (in mice) to thousands (in humans) of individual myocytes. To become a myocyte capable of fusion, a myoblast must commit to never proliferating again, so there are adverse consequences for the animal if cells differentiate too slowly, too quickly, or without enough other myocytes nearby that they can fuse with. Our work suggests a contact-mediated mechanism by which a differentiated myocyte can signal to surrounding myoblasts that it has differentiated and is available for fusion, which promotes differentiation in those myoblasts, which then differentiate and signal to their neighbors, and so on, leading to rapid and coordinated differentiation of the whole population.

PI_NAMEs: CORNELISON, DAWN D (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Adhesions;Adult;adverse outcome;Animals;Binding;Biology;Birth;Cell Culture Techniques;Cell Differentiation process;Cell membrane;Cell Physiology;Cell surface;Cells;Cephalic;Communities;Data;density;Development;Developmental Process;Differentiation Antigens;differentiation in vitro;Embryo;Eph Family Receptors;Ephrin-A5;Ephrins;Epigenetic Process;Exhibits;experimental study;Exposure to;Extracellular Domain;fetal;Fiber;Genetic Transcription;Giant Cells;Hindlimb;Human;Hypertrophy;In Vitro;in vivo;in vivo regeneration;Individual;Injury;innovation;insight;Lead;Life;Ligands;Link;Maps;Mediating;Mediator;member;Membrane;Modeling;Molecular;Mus;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;muscle form;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;muscle strength;Myoblasts;myogenesis;Myogenin;Natural regeneration;Neural Tube Closure;Phenotype;Population;postnatal;precursor cell;prevent;Process;Proliferating;protein protein interaction;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Regenerative Medicine;Resistance;retinal axon;Role;Serum;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Skeletal Muscle;stem cell expansion;Surface;Testing;Tissue Differentiation;Tissue Engineering;Tissues;transcription factor;translational applications;Vertebrates;Work

PROJECT_TITLE: EphA7 promotes contact-dependent myogenesis


ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: PUBLIC HEALTH NARRATIVE The aging and rural populations of northern New England suffer from numerous chronic health issues, including cancer, obesity, diabetes, cardiovascular disease, and substance abuse. The Northern New England Clinical and Translational Research Network, which includes healthcare, educational and research institutions in Maine, Vermont, and New Hampshire, has helped build a foundation for clinical and translational research in the tri-state region. In this renewal application, our goal is to strengthen our network of clinical and translational research through a learning infrastructure that is supported by the principles of diversity, inclusion, and equity, for the benefit of all residents in our region.

PI_NAMEs: ROSEN, CLIFFORD JAMES (contact);STEIN, GARY S.

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Aging;American;Area;Atherosclerosis;Award;Biometry;Cardiovascular Diseases;career;Centers of Research Excellence;Chronic;Clinical Data;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Collaborations;Communication;Communities;community based research;community engagement;Community Health;community involvement;Community Outreach;Coupled;COVID-19;COVID-19 pandemic;Cultural Diversity;Data;Development;Diabetes Mellitus;Disease;Education;Environment;Epidemiology;equity, diversity, and inclusion;Evaluation;Extramural Activities;Faculty;flexibility;food insecurity;Foundations;Funding;Funding Mechanisms;Goals;Governing Board;Grant;Health;health communication;health difference;health disparity;health equity;Healthcare;HPV vaccine hesitancy;Human Resources;Immigrant;improved;Infrastructure;innovation;Institution;Leadership;Learning;learning progression;Link;Maine;Malignant Neoplasms;Mentors;Mentorship;Modeling;Native American population;Native Americans;New England;New Hampshire;novel;novel strategies;Obesity;Opiate Addiction;Opioid;Passamaquoddy;Patient Care;patient oriented;Peer Review;Penobscot;Pilot Projects;Play;Population;Populations at Risk;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;practice-based research network;Predisposition;Primary Care;primary care practice;programs;Public Health;Publications;Registries;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Reservations;Resource Sharing;Resources;Role;Rural;Rural Health;Rural Population;rurality;Services;Site;Substance abuse problem;Substance Use Disorder;suburban communities;technical report;Technology;telehealth;Toxic Environmental Substances;Training;Training Programs;Translational Research;Tribes;underserved community;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Urban Population;urban underserved;Vermont


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: ROSEN, CLIFFORD JAMES (contact)

PROJECT_TERMS: addiction;Address;Advocate;Affect;biomedical informatics;career development;Chronic Disease;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Collaborations;collaborative environment;college;Communities;community engagement;Community Health;Community Outreach;COVID-19;COVID-19 pandemic;Development;disorder prevention;educational atmosphere;Educational Curriculum;equity, diversity, and inclusion;Evaluation;Financial Support;Fostering;Funding;Goals;Governing Board;Health;health care delivery;Health Care Research;health disparity;health inequalities;Health Personnel;Healthcare;Hospitals;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Lead;Leadership;Maine;Medical center;Medicine;member;Mentors;Mission;Modeling;New England;New Hampshire;Outcome;outreach;pandemic disease;Performance;Physicians;population health;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;practice-based research network;Prevention;Primary Health Care;Process;programs;Research;Research Infrastructure;Research Personnel;Resources;Rural;rural area;Rural Community;rural dwellers;Rural Health;rural healthcare;Rural Population;Scientist;Services;Structure;support network;survivorship;Training;Translational Research;translational scientist;underserved community;Universities;Urban Population;urban underserved;Vermont;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

PI_NAMEs: LUEBBERS, KIMBERLY  (contact)

PROJECT_TERMS: acute care;Attention;care outcomes;career;career development;career networking;Centers of Research Excellence;Clinical;Clinical Investigator;Clinical Research;clinical translation;cohort;Collaborations;Communities;Community Health;Community Healthcare;Data Scientist;Development;Education;equity, diversity, and inclusion;experience;Extramural Activities;falls;Funding;Health;health disparity;Healthcare;Hybrids;Improve Access;improved;innovation;inter-institutional;Internet;K-Series Research Career Programs;Knowledge;Laboratory Scientists;Leadership;Maine;Medical Students;Mentors;Mentorship;Needs Assessment;Neighborhood Health Center;New England;New Hampshire;Outcome;Phase;pilot test;practice-based research network;primary care clinic;primary care practice;programs;Research;research and development;Research Infrastructure;Research Personnel;Resources;rural disparities;Schedule;Scholars Program;Scholarship;Science;skills;social health determinants;success;symposium;Testing;Time;Training;Training and Education;Training Programs;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Universities;Vermont;Vocational Guidance

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Immunization;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Despite decades of significant progress, cancer is still one of the leading causes of death worldwide. We discovered that an antibody that binds to the G protein-coupled receptor, GPR160, has a direct anti-cancer effect against human colon cancer and triple negative breast cancer cells and greatly increases the effect of the cytotoxins, oxaliplatin and cisplatin. Our goal is to develop a human monoclonal anti-GPR160 antibody suitable for testing in patients.

PI_NAMEs: SALVEMINI, DANIELA  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Affinity;Affinity Chromatography;Alloys;Amino Acid Sequence;anti-cancer;anti-cancer treatment;Antibodies;Antibody Therapy;Avidity;Binding;Biological Assay;Biological Products;Breast;Breast Cancer Cell;Breast Cancer cell line;cancer cell;Cancer cell line;cancer therapy;Cause of Death;Cell Culture Techniques;Cell Line;Cell Survival;Cells;Chemosensitization;Cisplatin;Clinical;clinical effect;clinical efficacy;clinical predictors;Colon;colon cancer cell line;Colon Carcinoma;Combined Modality Therapy;cytotoxic;Cytotoxin;Data;Development;Dose;Dose Limiting;Elements;Esophagus;experimental study;extracellular;Flow Cytometry;G-Protein-Coupled Receptors;Genes;Goals;Human;Human Cell Line;human monoclonal antibodies;Hybridomas;Immunize;Immunodeficient Mouse;improved;In Vitro;in vitro Model;in vivo;Keyhole Limpet Hemocyanin;Ligands;Light;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;MDA MB 231;Measures;Mediating;Modeling;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;neoplastic cell;Oryctolagus cuniculus;overexpression;oxaliplatin;Paclitaxel;Patients;pharmacologic;polyclonal antibody;programs;Prostate;Publications;receptor;response;Role;scale up;side effect;small molecule;Stomach;success;SW480;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapy development;Toxic effect;Transgenic Mice;Translating;Trastuzumab;Treatment-Related Cancer;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;Uncertainty;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: GPR160 antibody development for cancer treatment


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Rural Health;Social Determinants of Health

PI_NAMEs: SANTANGELO, SUSAN L (contact)

PROJECT_TERMS: Acceleration;Adopted;American;analytical method;analytical tool;Artificial Intelligence;Biometry;career;Clinical;Clinical Investigator;Clinical Research;Collaborations;collaborative environment;college;community engaged approach;community engagement;Community Outreach;computer infrastructure;Computer software;dashboard;Data;data access;data infrastructure;Data Science;data sharing;data warehouse;design;Development;Discipline;Education;Education and Outreach;educational atmosphere;Elements;Epidemiology;Ethics;Food;Fostering;Funding;Goals;Health;health care service organization;Homelessness;human disease;human model;Human Resources;Immigrant;improved;innovation;Institution;inter-institutional;interest;Investments;Link;Machine Learning;Maine;Medicine;Mentorship;Methodology;Methods;Mission;Modeling;multidisciplinary;Native American population;New England;New Hampshire;Opioid;outreach;Post-Acute Sequelae of SARS-CoV-2 Infection;predictive modeling;Research;Research Design;Research Personnel;Resources;Rural;Sampling;Scientist;Services;Statistical Methods;statistics;success;Survey Methodology;Technology;tool;Training;Translational Research;Underserved Population;Universities;Vermont;Vulnerable Populations;web interface;Work

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Genomic instability underlies many human diseases. This project will investigate the role of the conserved HELLS ATP dependent chromatin remodelers in regulation of DNA repair and genome stability. Understanding chromatin-based regulation of genome stability is critically important to advance understanding of the molecular events leading to genome instability, and ultimately to facilitate development of new approaches in disease prevention, diagnosis and treatment.

PI_NAMEs: CZAJA, WIOLETTA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Alkylating Agents;Alkylation;Area;base;Biological Assay;Cause of Death;Cell Death;Cell Survival;Cells;Centromere;Chromatin;chromatin remodeling;Chromosomal Breaks;Chromosomal Rearrangement;Chromosome abnormality;Cytoprotection;Data;Development;Diagnosis;Disease;disorder prevention;DNA;DNA Alkylation;DNA Damage;DNA Methylation;DNA Repair;DNA Repair Pathway;DNA replication fork;epigenomics;Etiology;Eukaryota;Event;Exhibits;Exposure to;Gametogenesis;Genetic;Genome;Genome Stability;genome-wide;Genomic approach;Genomic Instability;genomic locus;Genomics;Genotoxic Stress;Goals;HELLS gene;Heterochromatin;Human;human disease;Hypersensitivity;Immune system;immunodeficiency;immunodeficiency-centromeric instability-facial anomalies syndrome;Immunofluorescence Immunologic;Immunologic Deficiency Syndromes;insight;Knowledge;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;member;Metabolism;model organism;Modeling;Molecular;Mus;Mutagens;mutant;Mutation;Neurospora;Neurospora crassa;Nonhomologous DNA End Joining;novel;novel strategies;Organism;Pathway interactions;Phenotype;Play;prevent;Proteins;Proteomics;Regulation;repaired;Reporter;Research;response;Role;Toxic effect

PROJECT_TITLE: Role of HELLS chromatin remodeler in genome maintenance

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: CARNEY, JAN KIRK (contact)

PROJECT_TERMS: Address;Adoption;Area;Basic Science;Chronic Disease;Clinical;clinical practice;Clinical Research;clinical research site;Collaborations;Communication;Communities;community based research;community engaged approach;community engaged research;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community partnership;Community Practice;community research;COVID-19;Development;Disparity;diversity and inclusion;Education;Environment;Equity;experience;Face;Federally Qualified Health Center;fighting;Goals;Health;health care service organization;health disparity;health equity;health equity promotion;health inequalities;improved;Individual;innovation;interest;Investigation;learning community;Link;Maine;member;New England;New Hampshire;news;Outcome;Patient Representative;Persons;Pilot Projects;Population;Practice based research;practice-based research network;Process;programs;Public Health;Reduce health disparities;Research;Research Personnel;Research Priority;Research Project Grants;Rural;Rural Community;Rural Health;rural healthcare;Rural Hospitals;Science;social determinants;social health determinants;Structure;Students;success;System;Targeted Research;Training;translational pipeline;Translational Research;Translations;Trust;Vermont;Vision;Work

PROJECT_TITLE: Community Engagement and Outreach Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the spectrum of neurodevelopmental outcomes for children exposed to Zika-virus in utero is not known at school age and this knowledge is necessary to inform primary and sub-specialty medical providers, educational systems, and public health policy. This knowledge can also improve preparedness for future infectious outbreaks that can affect the developing brain. The proposed research is relevant to NIH's mission because it aims to enhance the lives of children and optimize abilities for all.

PI_NAMEs: MULKEY, SARAH BETH (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 7 year old;Affect;Age;Age Months;Assessment tool;authority;Award;Behavior;Birth;Brain;brain abnormalities;brain magnetic resonance imaging;Brazil;care providers;Caribbean region;Caring;Centers for Disease Control and Prevention (U.S.);Cephalic;Child;Child Development;Child Health;Childhood;Clinical;cohort;Collaborations;Colombia;Colombian;Communicable Diseases;comparison control;Complex;congenital zika syndrome;Congresses;Data;Dedications;design;Development;Developmental Delay Disorders;Disease Outbreaks;Education;Educational Intervention;Emigrations;Epidemic;Evaluation;executive function;Family;fetal;follow-up;Future;Goals;Guidelines;Health Policy;Hearing;hearing impairment;human old age (65+);Image;improved;in utero;Individual;infancy;Infant;Injury;innovation;International;Intervention;Knowledge;Life;Location;Magnetic Resonance Imaging;Manuscripts;Measures;Medical;Mission;Mothers;Motor;multimodality;Neonatal;neurodevelopment;Neurodevelopmental Impairment;neuroimaging;Neurologic;Neurological outcome;Neuropsychology;novel;Outcome;Pediatric Neurology;Perinatal Exposure;Phenotype;postnatal;Pregnancy;Pregnant Women;prenatal;prenatal exposure;programs;Provider;Public Health;Published Comment;Publishing;quantitative imaging;Questionnaires;radiologist;Readiness;Research;Rest;Risk;School-Age Population;Shapes;Structure;System;Testing;Travel;ultrasound;United States;United States National Institutes of Health;United States Virgin Islands;Vascular Diseases;Visual impairment;Washington;Work;ZIKA;Zika Virus;ZIKV exposure;ZIKV infection

PROJECT_TITLE: Childhood Outcome After In Utero ZIKV Exposure

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Rural Health

PI_NAMEs: CARR, FRANCES E. (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Archives;Articulation;Biological;Biomedical Research;Cardiovascular Diseases;career development;Cells;cellular imaging;Centers of Research Excellence;Clinical;clinical investigation;Clinical Research;Collaborations;Communication;community engagement;Community Outreach;Complex;Computer Models;Core Facility;cost;COVID-19 testing;Credentialing;Data;Data Collection;data management;design;Development;Diagnostic;Disease;Education;Emerging Technologies;Environment;epidemiology study;epigenomics;equity, diversity, and inclusion;Experimental Designs;Fostering;Funding;Future;Genomics;Goals;Health;health care delivery;healthcare community;Imaging technology;Industry;Informatics;Information Systems;Infrastructure;innovation;innovative technologies;Institution;instrumentation;interdisciplinary collaboration;Leadership;lipidomics;Malignant Neoplasms;meetings;Mentors;Methods;Mission;Modeling;molecular diagnostics;mouse model;multiple data types;multiple omics;New England;new technology;novel;novel strategies;outreach;Persons;Phenotype;Physicians;Play;practice-based research network;precision medicine;preclinical study;Preparation;Price;Private Sector;Process;programs;Proteomics;Public Health;Reproducibility of Results;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Role;Rural;Rural Population;Science;Scientist;Secure;Services;Specificity;statistics;Substance abuse problem;success;Systems Biology;Teacher Professional Development;Technology;Tissues;Training;Training and Education;transcriptomics;Translating;translational goal;translational impact;Translational Research;United States National Institutes of Health;virtual;webinar

PROJECT_TITLE: Translational Research Technologies Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: JOLY, BRENDA MORISSETTE (contact)

PROJECT_TERMS: Award;Bioinformatics;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Collection;Communication;Communities;community based research;Community Health;Data;Data Collection;Data Management Resources;Decision Making;design;Development;digital;Education;Enrollment;Ensure;Environment;Epidemiology;Evaluation;Familiarity;flexibility;Fostering;Funding;Goals;Guidelines;Health;implementation efforts;improved;Individual;informant;Infrastructure;innovation;Institution;Institutional Review Boards;Interview;Lead;Leadership;Learning;Logic;Maine;Maps;Measures;meetings;member;Methods;Mission;Modeling;Monitor;multidisciplinary;New England;New Hampshire;Notification;Outcome;peer learning;Performance;Persons;population health;prevention evaluation;Process;programs;Research;Research Design;Research Infrastructure;Research Personnel;rural area;Science;Services;success;Surveys;System;Techniques;tool;Translating;translational potential;Translational Research;Vermont;virtual;Visual;Visualization

PROJECT_TITLE: Tracking and Evaluation Core


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention

PHR: PROJECT NARRATIVE Chronic lung disease is thought to originate from the most distal airspaces, but clinical measures such as spirometry and CT are unable to probe these regions directly. In this ancillary study to the NHLBI-funded Lung Health Cohort, we will use hyperpolarized 129Xe MRI to assess alveolar structure and function in young adults at the ages of peak lung health. In doing so, we aim to determine the structural basis for low normal lung function and unexplained respiratory symptoms that may be the precursors to chronic lung disease.

PI_NAMEs: NIEDBALSKI, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Acceleration;Age;Air;Alveolar;Alveolar Duct;American Lung Association;Ancillary Study;associated symptom;base;Blood capillaries;Caring;Cessation of life;Chronic;Chronic lung disease;Clinical;Clinical Markers;Clinical Research;cohort;Cohort Studies;common symptom;Complement;Coughing;Data;Defect;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disease;Distal;Dyspnea;Environmental Exposure;fitness;Foundations;Funding;Future;Gases;Goals;Image;Imaging Techniques;Impairment;in vivo;Individual;insight;Investigation;Ionizing radiation;Life;Link;Long COVID;Lung;Lung Diseases;lung health;lung injury;Magnetic Resonance Imaging;Maps;Measurable;Measurement;Measures;Membrane;Modeling;multi-site trial;Nasal Epithelium;National Heart, Lung, and Blood Institute;novel imaging technique;older adult;Oranges;Outcome;Outcome Study;palliation;Parents;Participant;Patients;Physiological;poor health outcome;Population;Populations at Risk;Predisposition;Prevention;Process;Protocols documentation;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Gas Exchange;Recommendation;Recording of previous events;Regimen;Research Personnel;respiratory;respiratory imaging;Respiratory Signs and Symptoms;Risk Factors;Site;Smoker;Social Behavior;Spirometry;Sputum;Structural defect;structural determinants;Structure;symptomatology;Symptoms;targeted treatment;Techniques;Testing;Therapeutic Intervention;transcriptome;ventilation;Wheezing;Work;X-Ray Computed Tomography;Xenon;young adult

PROJECT_TITLE: Hyperpolarized 129Xe MRI to identify structural determinants of low lung function and respiratory symptoms in young adults from the Lung Health Cohort

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: NADEAU, JOSEPH H. (contact)

PROJECT_TERMS: Acceleration;Address;analytical method;Applications Grants;Award;barrier to care;behavioral health;Biometry;career;Chronic Disease;Clinical;Clinical Investigator;Clinical Research;Collaborations;Communities;community collaboration;community engagement;Community Outreach;community partners;Consultations;COVID-19;COVID-19 pandemic;Data Analyses;design;Development;Discipline;Disease;diversity and inclusion;Early Diagnosis;Ensure;Epidemiology;equity, diversity, and inclusion;experience;Extramural Activities;Face;Funding;Goals;Grant;Health;health care availability;health care delivery;health communication;health disparity;health inequalities;Health Services;Healthcare;IACUC;improved;Incentives;Institution;Institutional Review Boards;interdisciplinary collaboration;Intervention;investigator training;Leadership;Maine;meetings;Mentors;Mentorship;New England;Newsletter;Opiate Addiction;Outcome;Passamaquoddy;Phase;Physicians;Pilot Projects;Practice based research;practice-based research network;Prevention;Primary Care Physician;Process;programs;prospective;Public Health;public health research;Publications;recruit;Research;Research Design;Research Personnel;Research Support;Resources;rural area;Rural Community;Rural Health;rural underserved;Scientist;social media;Study Section;success;survivorship;Technology;Time;Translational Research;translational scientist;translational study;Translations;Tribes;underserved community;Universities;Urban Community;web site;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The major genetic contribution of the human leukocyte antigen (HLA) region to disease risk has been recognized for nearly fifty years, with hundreds of associations observed in autoimmunity, infectious disease, cancer, and major drug-hypersensitivities. Because of its pivotal role in the immune response to pathogens, we expect that HLA variation will also be found to play a role in SARS-CoV-2 infection and/or COVID-19 outcomes. Here, we will examine the association of HLA and other nearby genes with COVID-19 disease outcomes and explore the molecular basis for these associations.

PI_NAMEs: HOLLENBACH, JILL ALLISON (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;6p21;Alleles;Antibodies;antigen binding;Antigen Presentation;Antigenic Variation;Autoimmunity;B-Lymphocytes;Big Data;Bioinformatics;Biology;Blood;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Chromosomes;citizen science;Clinical;Clinical Data;cohort;Communicable Diseases;Coupled;Coupling;COVID-19;COVID-19 patient;Custom;cytokine;Data;data resource;Data Set;deep sequencing;Disease;Disease Outcome;disorder risk;donor stem cell;Drug Hypersensitivity;Elements;Epidemiology;Epitopes;Fostering;Genes;Genetic;Genomic Segment;Genomics;Genotype;Goals;Health;Health system;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;HLA Antigens;Human;Human Genome;Immune;immune activation;Immune response;Immune system;Immunity;Immunogenetics;Immunologics;Immunology;Immunotherapy;Infection;innovation;insight;Investigation;Laboratories;Link;longitudinal analysis;Lung;Major Histocompatibility Complex;Malignant Neoplasms;Maps;Marrow;Medical;Methods;mobile computing;Molecular;Molecular Biology;Nature;next generation sequencing;novel;Nucleoproteins;Outcome;pathogen;Patients;Peptides;Phenotype;Population Genetics;programs;Proteins;Proteomics;Registries;repository;Resolution;Resources;response;Risk Factors;Role;Sample Size;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;smartphone application;Specificity;Symptoms;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Untranslated RNA;vaccine development;Validation;Variant;Virus Diseases;volunteer

PROJECT_TITLE: MHC Variation in Host Response to SARS-CoV2 and COVID-19 Outcomes

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE The circadian rhythm orchestrates critical physiological functions at the molecular, cell, and organismal levels. While degradation of the circadian rhythm is known to be associated with aging and believed to contribute to Alzheimer's and other age-related diseases, the underlying molecular mechanisms remain poorly characterized. This project aims to develop and apply powerful computational tools to investigate circadian patterns of gene activity in older adults, with the goal of enabling personalized circadian medicine for an aging population.

PI_NAMEs: BRAUN, ROSEMARY  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Address;Affect;age related changes;age-related disease;Aging;aging population;Alzheimer's Disease;Alzheimer's disease risk;Articulation;Behavioral;Biochemical;Blood;Blood specimen;Cells;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Clinic;Complex;computerized tools;Coupled;Data;data imputation;Data Set;Dementia;Development;Diagnostic;Disease;dynamic system;Elderly;Ensure;Epidemiology;Exhibits;flexibility;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Health;healthy aging;Hour;Human;innovation;Link;machine learning algorithm;Medicine;Metadata;Methods;Molecular;Nerve Degeneration;new technology;Noise;novel;older adult;Older Population;Output;Patients;Pattern;Persons;Phase;Phenotype;Physiological;Process;Public Health;reconstruction;Repression;response;Sampling;Series;Shapes;Signal Transduction;Sleep disturbances;Systems Theory;Technology;Testing;therapeutic target;Time;Tissues;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;United States;Variant;Work;young adult

PROJECT_TITLE: Reconstructing the temporal landscape of gene regulation in aging