NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Rett Syndrome is a severe neurodevelopmental disorder caused by a mutation in the X-linked gene, MECP2, which encodes a chromatin-associated protein crucial for neuronal development. To develop a disease-specific treatment, we have identified an X-reactivating methodology that can restore endogenous MECP2 expression in the brain. In the 1st funding cycle, we achieved an in vivo proof-of-concept for phenotypic rescue in a disease-relevant animal model and now aim to complete PK/PD studies and identify development candidates.

PI_NAMEs: LEE, JEANNIE T (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: 3 year old;Affect;Age;Alleles;Animal Model;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;autism spectrum disorder;Beginning of Life;Behavioral;Brain;Cardiac;Cell model;Cells;Characteristics;Chromatin;Consumption;Data;Decitabine;Development;Disease;DNA Maintenance;DNA Methylation;DNA Methyltransferase Inhibitor;DNA Modification Methylases;Dose;Drug Industry;Female;Fibroblasts;Fragile X Syndrome;Functional disorder;Funding;Gene Mutation;gene product;gene therapy;Genes;Genetic;Genetic Diseases;girls;Goals;Heterozygote;Human;human induced pluripotent stem cells;in vivo;Incidence;Individual;Inherited;inhibitor;Injections;interest;Intervention;Investigation;Laboratories;lead candidate;Link;male;Mammalian Cell;Methodology;Methods;Methyl-CpG-Binding Protein 2;mouse model;Mus;mutant;Mutation;Nature;Nervous System Disorder;Neurodevelopmental Disorder;neuron development;Neurons;Nuclear Pore Complex;parent grant;Patients;Performance;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacotherapy;Phenotype;Physiological;protein expression;Proteins;prototype;Research;restoration;Rett Syndrome;Risk;RNA;Rodent;Schedule;Scientist;Seizures;Sleep Apnea Syndromes;small molecule inhibitor;standard of care;success;Survival Analysis;Symptoms;Syndrome;Technology;Testing;Toxicology;transcriptomics;treatment response;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Advancing an XIST ASO candidate for the treatment of Rett Syndrome

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: PROJECT NARRATIVE With the rising incidence of antibiotic resistance and the steady decline in the discovery of new antibiotics, there is a critical need for the development of strategies to preserve the efficacy of existing antibiotics. The objective of this application is to investigate the combination of antimicrobial blue light and antibiotics for a synergistically improved antimicrobial activity and/or for the preservation/potentiation of the potency of current antibiotics. If this strategy can be demonstrated to be both effective and safe, this research will address, at least partially, the serious problem of emerging antibiotic resistance by providing a much-needed innovative strategy.

PI_NAMEs: DAI, TIANHONG  (contact);HOOPER, DAVID C

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abscess;Address;Adjuvant;Animals;Antibiotic Resistance;antibiotic resistant infections;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Effect;Antimicrobial Resistance;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;beta-Lactam Resistance;beta-Lactamase;carcinogenicity;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;Cellular biology;Chemosensitization;Chinchilla (genus);Clinical;combat;Combating Antibiotic Resistant Bacteria;Combined Antibiotics;Combined Modality Therapy;Cutaneous;cytokine;Dangerousness;Development;DNA Damage;Drops;Drug Delivery Systems;Ear;efficacy evaluation;emerging antibiotic resistance;Exposure to;fluoroquinolone resistance;Future;Glycopeptides;Government;Health;Human;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;Individual;Infection;Inflammatory;Inflammatory Response;innovation;interstitial;invention;Levaquin;Light;Mediating;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Modeling;Multiple Bacterial Drug Resistance;Mus;Needles;new combination therapies;Nonpharmacologic Therapy;novel;novel therapeutics;Optics;Otorrhea;overexpression;Oxidative Stress;Penicillins;Persons;preservation;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;PUVA Photochemotherapy;Reaction;Reactive Oxygen Species;Regimen;Reporting;Research;research and development;Research Personnel;Resistance;Resistance development;safety study;Site;Sulfamethoxazole;Sum;Surface;synergism;Technology;Tissues;transcriptome;Treatment Efficacy;Tube;Tympanostomy;Up-Regulation;Virulence;wound healing

PROJECT_TITLE: Combination of Antimicrobial Blue Light and Antibiotics to Combat Multidrug-Resistant Bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: PROJECT NARRATIVE Remarkably, 25% of patients with fatty liver disease (FLD) are lean and compared to non-lean (overweight and obese) individuals with FLD, they have a two-fold increased risk of cardiovascular and liver-related mortality. Our goal is to understand convergent and divergent features of lean and non-lean FLD, by comparing associated clinical and genetic risk factors in those with and without substantial alcohol exposure in the VA Million Veteran Program (MVP). This project will assemble the largest ever multi-ancestry cohort of persons with and without FLD based on the application of Automatic Liver Attenuation Region-of-interest-based Measurement (ALARM), a deep learning tool to clinically obtained non-contrast abdominal CT scans. This work has the potential to substantially improve our understanding of the clinical and genetic drivers of FLD in a quarter of those affected. Given the large number of such patients within the VA health system and their increased mortality, this work has the potential to significantly impact the practice of clinical medicine.

PI_NAMEs: JUSTICE, AMY CAROLINE (contact)

PROJECT_TERMS: abdominal CT;Affect;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Area Under Curve;artificial intelligence method;Asian population;attenuation;Blinded;Body mass index;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Cirrhosis;Classification;Clinical;clinical care;Clinical Medicine;clinical practice;clinical risk;Code;cohort;cost effective;Data;deep learning;deep learning algorithm;demographics;Diabetes Mellitus;Diagnosis;Diagnostic;drinking;Dyslipidemias;Electronic Health Record;Event;Fatty Liver;fatty liver disease;Foundations;Funding;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic variant;genome wide association study;Genotype;Goals;Health system;Hepatology;high risk;Histologic;Histopathology;Hypertension;Image;improved;Individual;interest;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Liver Function Tests;Measurement;Medical Imaging;Mentorship;Metabolic;Metabolic dysfunction;Modeling;mortality;non-alcoholic;novel;novel therapeutics;Obesity;Outcome;Overweight;Patients;Performance;Persons;Phenotype;Phospholipase;Physicians;polysubstance use;Population;Populations at Risk;precision medicine;Prediabetes syndrome;programs;Radiology Specialty;Reporting;Research;Resources;Risk Factors;Scanning;Scientist;screening guidelines;Series;Single Nucleotide Polymorphism;Specificity;System;Testing;Thinness;tool;Transaminases;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Genetic Vulnerability for Sustained Multi-Substance Use in MVP

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 DEIR-W (01)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Early life exposures to neurotoxic metals may disrupt children’s sleep, which may be mediated by circulating extracellular vesicles and their microRNA and metabolite cargoes. We will study the relationship between extracellular vesicle cargo and sleep disruption during the first 10–12 years of life in a well-defined birth cohort. Our focus on early-life exposures has important implications—our study may inform stricter regulations for complex metal mixtures and will help direct public health interventions to specific time windows with high plasticity, i.e., prenatal and early life, when simple interventions could have long-lasting health benefits that impact the entire life course.

PI_NAMEs: BARUPAL, DINESH ;KUPSCO, ALLISON  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: 1 year old;12 year old;7 year old;Ablation;actigraphy;Adverse effects;Affect;Age;Animal Model;Arsenic;Behavior Disorders;Behavioral;Binding;biobank;Biological Markers;Biological Process;Biology;Biometry;Birth;Blood;Blood Circulation;Blood specimen;Brain;Cadmium;capsule;cardiometabolic risk;Cardiovascular system;causal model;Cell secretion;Cells;Chemicals;Child;Child Development;Childhood;circadian;Circadian Rhythms;Cities;Cognition Disorders;cognitive development;cohort;Data;Development;Distant;early childhood;early detection biomarkers;early life exposure;Emotional;Emotional disorder;Environment;Epigenetic Process;Exposure to;extracellular vesicles;Future;Growth;Health;Health Benefit;high risk;Human;human data;human study;implementation intervention;improved;In Vitro;in vivo;Individual;individualized prevention;Inductively Coupled Plasma Mass Spectrometry;infancy;innovation;Intervention;Investigation;Joints;Lasers;Lead;Learning Disorders;Life;Life Cycle Stages;Link;Liquid Chromatography;Longitudinal cohort;Longitudinal Studies;Manganese;Mass Spectrum Analysis;Measures;Mediating;Mediation;Membrane;Metabolic;Metabolic Diseases;metabolome;metabolomics;metal complex;Metal exposure;Metals;Mexico;MicroRNAs;modifiable risk;Molecular;neurotoxic;neurotoxicology;Neurotransmitters;novel;novel strategies;Obesity;Outcome;particle;Pathway Analysis;Pathway interactions;Pattern;Pediatrics;Performance;Phenotype;Physiological;Plasma;postnatal;postnatal period;Predisposition;Pregnancy;prenatal;prevent;public health intervention;recruit;Regulation;Regulatory Pathway;Research;Research Personnel;Resolution;Resources;Rest;Risk Factors;Role;Safety;Second Pregnancy Trimester;Signal Transduction;Sleep;sleep abnormalities;Sleep disturbances;sleep pattern;sleep quality;social stressor;Statistical Data Interpretation;Statistical Models;suprachiasmatic nucleus;System;Time;Tissues;Tooth structure;transcriptome;transcriptomics;transmission process;Trees;Vesicle;vesicle transport;vesicular release;Visit

PROJECT_TITLE: Metal Mixtures, MicroRNAs and Metabolomics in Extracellular Vesicles, and Early-life Programming of Childhood Sleep Patterns: A Longitudinal Study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: NARRATIVE This proposal will investigate the use of bacteriophage, which are viruses that infect and kill bacteria, to treat Mycobacterium abscessus (Mabs) infection. Using a preclinical model, we will study in vivo phage exposure (pharmacokinetics, PK) and its impact on Mabs infection (pharmacodynamics, PD) to build an in silico quantitative systems pharmacology (QSP) model that can be used to design effective phage dosing strategies.

PI_NAMEs: BRAUNSTEIN, MIRIAM S. (contact);RAO, GAURI G

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Address;Amikacin;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;bactericide;Bacteriophages;Bronchiectasis;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Combined Antibiotics;Combined Modality Therapy;Cystic Fibrosis;Data;design;Disease;Dose;Drug Kinetics;Drug resistance;drug resistant bacteria;Encapsulated;Environment;Exhibits;Formulation;Functional disorder;improved;in silico;In Vitro;in vivo;Individual;Infection;insight;Intravenous;Knowledge;liposomal formulation;Liposomes;Lung;Lung Diseases;Lung infections;Macrophage;Mammalian Cell;Modeling;mouse model;Mus;Mycobacterium abscessus;Mycobacterium Infections;non-tuberculosis mycobacteria;novel therapeutics;Outcome;Pathology;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacotherapy;Pre-Clinical Model;pulmonary function;Regimen;Respiratory physiology;Rifabutin;Route;small molecule;System;Therapeutic Uses;therapy outcome;Time;Translations;Virus

PROJECT_TITLE: In vivo assessment and optimization of phage PK/PD for the treatment of pulmonary Mycobacterium abscessus infection


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Over the last 5 years, we have finished a “first-in-human” clinical trial of an oncolytic viral immunotherapy in subjects with Glioblastoma (GBM) one of the most lethal cancers. We found that subject survival correlated with viral serology with biologic and immunologic evidence of significant immune activation. Coming back to the lab, we will study in mouse models of GBM if the pre-existent memory immune response to the injected oncolytic virus contributes to tumor rejection, as implied by our clinical trial findings.

PI_NAMEs: CHIOCCA, E. ANTONIO (contact);NAKASHIMA, HIROSHI

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: anti-cancer;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;Back;Biological;Brain Glioblastoma;Brain Neoplasms;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8B1 gene;Clinical Trials;Communicable Diseases;Contracts;cytokine;Cytomegalovirus;cytotoxic;cytotoxicity;Data;Effectiveness;Effector Cell;effector T cell;Evolution;exhaustion;Exposure to;Failure;FDA approved;first-in-human;Funding;Genetic;Glioblastoma;Granzyme;Herpesvirus 1;Human;Human Herpesvirus 4;IL18 gene;immune activation;Immune checkpoint inhibitor;Immune response;Immunity;Immunologic Memory;Immunologics;Immunotherapy;improved;Infiltration;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;Influenza;Injections;Interferon Type II;Interleukin-15;Knowledge;Lead;Malignant neoplasm of brain;Malignant Neoplasms;Memory;Modality;Molecular;mouse model;Mus;neoplasm immunotherapy;novel;Oncolytic;Oncolytic Immunotherapy;oncolytic virotherapy;Oncolytic viruses;Patients;Pattern;perforin;Phase;phase I trial;Phenotype;Population;Process;Proliferating;Reaction;Recovery;Recurrence;Registries;Reporting;Role;seroconversion;Serology;standard of care;success;T cell infiltration;T cell response;T memory cell;T-Lymphocyte;Testing;therapeutic target;transcriptomics;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;uptake;Viral;Viral Antigens;Virus;Virus Replication;Visit

PROJECT_TITLE: Oncolytic Virus Therapeutic Responses Occur from Changes in the Glioblastoma Immune Microenvironment

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Pediatric brain cancers are the most deadly of childhood cancers, and limited treatment options exist. We seek to identify new avenues for treatment by performing analysis of existing pediatric brain tumor datasets using novel approaches that will explore gene networks within these tumors and will interrogate how the tumors communicate with the normal brain around them. Additionally, we will leverage new data generated from the normal, developing human brain to compare and contrast with the tumor data in an effort to more carefully pinpoint how these tumors emerge and what strategies are likely to effectively treat these pediatric brain cancers.

PI_NAMEs: TEITELL, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Adult;Algorithms;Archives;Atlases;Biological;Brain;brain cell;BRAIN initiative;Brain Neoplasms;cancer cell;cancer cell differentiation;Cancer Center Support Grant;cancer diagnosis;cancer subtypes;Cell Communication;cell type;Cells;Characteristics;Chemotherapy and/or radiation;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;Childhood Malignant Brain Tumor;Communication;Communities;Data;data portal;Data Set;Deposition;Development;Diagnosis;Diffuse intrinsic pontine glioma;driver mutation;Etiology;First Pregnancy Trimester;Foundations;gene network;Generations;Genes;Genetic Transcription;Goals;Growth;Human;Human Development;Individual;Infiltration;informatics tool;innovation;insight;interest;Joints;Lead;Ligands;Link;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;meetings;Meta-Analysis;Methods;migration;Molecular;Molecular Profiling;molecular subtypes;Molecular Target;multiple omics;Mutation;Network-based;Neurosciences;new therapeutic target;Normal Cell;novel;novel strategies;novel therapeutics;Oncogenic;Outcome;Pathway interactions;Patients;preservation;Prognosis;programs;public repository;Publications;Publishing;Quality of life;receptor;Regulation;repository;Research;Resources;Rest;Second Pregnancy Trimester;Signal Transduction;single cell analysis;single-cell RNA sequencing;Therapeutic;therapeutic target;Time;tool;transcription factor;tumor;tumor growth;tumor progression;Tumor Promotion

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ORG_CITY: STONY BROOK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative The proposed project is relevant to public health because it will develop a pretargeting platform for precision nuclear medicine that will reduces the harmful radiation-related toxicity of antibody-based radiopharmaceuticals. The platform will be a robust, safe, and convenient alternative to standard approaches with antibody-based radiopharmaceuticals that is widely applicable to enhancing human health through precision medicine, which is directly applicable to the mission of the NIH.

PI_NAMEs: HOUGHTON, JACOB  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Adamantane;Affinity;Antibodies;antibody conjugate;Antigen Targeting;Binding;Biodistribution;Blood;Cancer Model;cancer therapy;Carcinoembryonic Antigen;Cells;Chelating Agents;Clinical;clinical translation;Colorectal;Data;design;Development;Discipline of Nuclear Medicine;Dose;Dose Limiting;dosimetry;Drug Kinetics;Effectiveness;efficacy evaluation;Elements;Equilibrium;Evaluation;experimental study;Frequencies;Future;Goals;Half-Life;Health;Hematopoietic;Human;human disease;Hydrocarbons;Image;image guided;imaging platform;improved;In Vitro;in vivo;Injections;innovation;irradiation;Isotopes;Label;Lead;lead candidate;Libraries;Linear Energy Transfer;LS174T colon cancer cell line;macromolecule;Malignant Neoplasms;Marrow;Methods;Mission;Molecular;Molecular Target;Monoclonal Antibodies;mouse model;Mus;next generation;nuclear imaging;Organ;Outcome;Pancreas;particle therapy;precision medicine;Public Health;Publications;Published Comment;Radiation;Radiation Dose Unit;Radiation Toxicity;Radioactivity;Radioimmunotherapy;Radioisotopes;Radiolabeled;radioligand;Radiology Specialty;Radionuclide therapy;Radiopharmaceuticals;receptor;Regimen;Safety;Serum;single photon emission computed tomography;small molecule;stoichiometry;Structure;subcutaneous;success;Technology;theranostics;Therapeutic;Therapeutic Index;Time;Tissues;Toxic effect;translational study;Treatment Efficacy;treatment planning;treatment response;tumor;Tumor Antigens;tumor growth;United States National Institutes of Health;uptake;Validation;vector;Xenograft Model

PROJECT_TITLE: Radiotheranostic host:guest pretargeting with Pb-203 and Pb-212

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Cells employ a number of different DNA repair pathways to tolerate chemical agents that damage their genomic DNA. Of particular importance is non-homologous end joining (NHEJ) which is the primary pathway in humans that rejoins DNA double strand breaks. This project employs advanced microscopy approaches to understand the mechanism by which the NHEJ pathway functions normally and how its inappropriate use contributes to cancer.

PI_NAMEs: LOPARO, JOSEPH J. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antigen Receptors;Back;Binding;Biochemical;Biological Models;C-terminal;Cell Death;Cell-Free System;Cells;Chemical Agents;Chromosomal Rearrangement;Chromosomal translocation;Chromosome Pairing;Chromosomes;Clinical;clinical prognosis;Color;Complex;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair Pathway;DNA-PKcs;Double Strand Break Repair;egg;Enzymes;experimental study;Failure;Fluorescence Resonance Energy Transfer;G22P1 gene;Genetic Diseases;Genetic Materials;Genome;Genomic DNA;Goals;Health;Human;imaging approach;immunodeficiency;inhibitor;insertion/deletion mutation;insight;Ionizing radiation;Laboratories;Lesion;Ligase;Ligation;Malignant Neoplasms;Measurement;Mediating;Microscopy;Molecular;Monitor;Mutagenesis;mutant;Nonhomologous DNA End Joining;novel;nuclease;Oncogenic;Outcome;paralogous gene;Pathway interactions;Physiological;Play;Polymerase;protein protein interaction;Proteins;Reaction;recruit;repaired;Reporting;Resistance;Role;single molecule;single-molecule FRET;Structure;Synapses;Tail;Testing;therapeutic development;Time;tumor;Visualization;Work;Xenopus laevis;XRCC4 gene

PROJECT_TITLE: Visualizing DNA break repair: single-molecule studies of non-homologous end joining

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: PORTLAND

ORG_DEPT: BIOLOGY

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: A new ultracentrifuge at Portland State University will replace non-functional ultracentrifuges. This will allow students and researchers to deepen their education and perform research activities that are important to understand virus evolution, life in space, cancer, and how microbes interact with each other. These research and education activities are currently not possible at Portland State University.

PI_NAMEs: STEDMAN, KENNETH MARK (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: 20 year old;Age;Aging;Bacteria;Biology;Biomedical Research;Biophysics;Capsid Proteins;career;Cellular biology;Chemistry;Dedications;DNA;DNA Repair;Education;Educational Activities;Exposure to;Failure;First Generation College Students;Future;Graduation Rates;hyperthermophile;improved;instrument;Isopycnic Centrifugation;Laboratories;Laboratory Research;Membrane Proteins;Microbiology;Microgravity;Minority Groups;Molecular Biology;mutant;Physics;Proteomics;Recombinants;Research;Research Activity;Research Personnel;retention rate;RNA Probes;stable isotope;Students;System;Techniques;undergraduate student;Universities;university student;user-friendly;Virus;Virus-like particle

PROJECT_TITLE: Ultracentrifuge

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN JUAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: Project Narrative This project seeks to obtain an electron paramagnetic resonance instrument to boost the research productivity and biomedical educational training in Puerto Rico focused on characterizing paramagnetic species related to human health. In the body, many biomolecules are paramagnetic and their direct study can help to understand abnormalities that can lead to disease, to the discovery of new drugs, or to design optimal delivery of therapeutics or diagnostic agents. The research team of this project has diverse specializations, which will be applied to create new biochemistry course laboratory experiences, develop MRI contrast agents, electronic devices, and metal- based anticancer drugs, and to better understand biomolecular interactions that regulate important proteins and the diseases of cancer, HIV-1, myocardial infarction, and Huntington’s.

PI_NAMEs: TINOCO, ARTHUR DAVID (contact)

PROJECT_TERMS: Biocompatible Materials;Biomedical Research;Biophysics;Budgets;career;CCL7 gene;Chemistry;college;Colon;Development;Disease Progression;Drug Delivery Systems;Drug Design;Economics;Education;Electron Spin Resonance Spectroscopy;Event;exhibitions;Faculty Workshop;Fostering;Funding;graduate student;insight;Institution;instrument;instrumentation;interdisciplinary collaboration;Ions;laboratory experience;Link;Medical;Molecular;Natural Disasters;Natural Sciences;Nuclear Magnetic Resonance;Organism;Participant;Pharmacology and Toxicology;Physiology;Productivity;programs;Protein Biochemistry;Proteomics;Puerto Rico;Research;Research Personnel;Resources;Science;Specificity;Spin Labels;Students;System;Techniques;Traineeship;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: Enhancing Biomedical Education and Research through the Acquisition of an Electron Paramagnetic Resonance Instrument


ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE: Overall cancer mortality has decreased in the U.S. owing in part to significant progress in novel cancer therapeutics designed around new discoveries of how to harness the body’s immune response to cancer. Unfortunately, not all individuals with cancer have benefited equitably from this success, such as Hispanic/Latino (H/L) patients, in whom disparities in cancer outcomes are rooted, in some respects, in the development of these novel therapeutics. This project enables an integrative analysis of demographic, and clinical data combined with multi-omics approaches using longitudinal blood samples and tumor tissue from H/L patients with breast cancer to identify novel differences in the tumor immune microenvironments which will inform specific cellular immune targets that could significantly improve clinical trial design targeted for H/L patients and affect eligibility criteria for approved immune therapies.

PI_NAMEs: ROUSSOS TORRES, EVANTHIA THEODOSIOU (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Adult;Affect;anti-cancer research;Antitumor Response;Applications Grants;Asian;Biological Factors;Biomedical Computing;Biomedical Engineering;Blood;Blood specimen;Breast Cancer Patient;cancer care;cancer clinical trial;Cancer Diagnostics;cancer health disparity;Cancer Patient;cell type;Cells;checkpoint inhibition;Circulation;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Combined Modality Therapy;Communities;Complex;Comprehensive Cancer Center;Computational Biology;Consent;Data;Data Set;data tools;Demographic Analyses;design;Development;Diagnosis;digital;Discipline;disorder risk;Disparate;Disparity;Eligibility Determination;Equity;Flow Cytometry;Foundations;Future;General Population;Generations;Goals;HDAC4 gene;high risk;Hispanic;Histone Deacetylase Inhibitor;Human Resources;Immune;Immune response;Immune Targeting;Immunity;Immunologics;Immunologist;Immunooncology;Immunosuppression;Immunotherapy;improved;Individual;Infiltration;insight;Investigation;Latino;Latino Population;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Minority Groups;Minority Participation;minority patient;Modeling;mortality;multiple omics;Myelogenous;Myeloid-derived suppressor cells;Not Hispanic or Latino;novel;novel marker;novel therapeutics;Organoids;Outcome;participant enrollment;Pathologist;Pathology;patient population;patient response;Patients;Physicians;Population;Population Sciences;programs;Publications;Race;racial population;rational design;recruit;Research;Research Personnel;Research Proposals;Resistance;response;Role;sample collection;Sampling;Scientist;social;social health determinants;Socioeconomic Factors;Specimen;Stratification;success;T cell response;T-Cell Activation;T-Lymphocyte;Therapeutic;tool;treatment response;tumor;Tumor Bank;tumor immunology;tumor microenvironment;Tumor Subtype;Tumor Tissue;tumor-immune system interactions;Underrepresented Minority;willingness;Work;young woman

PROJECT_TITLE: The role of immunosuppression in the tumor microenvironment in Hispanic/Latino patients with breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J1)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Adherence;Adult;Affect;American Association of Cancer Research;anti-cancer research;anti-tumor immune response;Benchmarking;Bioinformatics;Biological;Biological Factors;Blood specimen;breast cancer metastasis;Breast Cancer Patient;Breast Cancer survivor;Breast Oncology;breast surgery;cancer care;cancer clinical trial;cancer health disparity;Cancer Patient;Cancer Therapy Evaluation Program;Caring;Cells;Cellular biology;checkpoint inhibition;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Collection;Combined Modality Therapy;Communities;community advisory board;community partners;Complex;Computational Biology;Data;Demographic Analyses;design;Development;Diagnosis;Discipline;disorder risk;Eligibility Determination;Ensure;Epidemiology;Equity;Ethnic Origin;Evaluation;experience;Faculty;follow-up;Funding;Future;General Population;Generations;Goals;Grant;HDAC4 gene;high risk;Hispanic;Histone Deacetylase Inhibitor;Immune;Immune response;Immune Targeting;Immunologics;Immunosuppression;Immunotherapy;improved;Individual;Infiltration;insight;Interdisciplinary Study;ipilimumab;Knowledge;Latino;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;medical specialties;Mentors;Mentorship;Minority Groups;Minority Participation;minority patient;Molecular;Monitor;mortality;multiple omics;Myeloid-derived suppressor cells;Nivolumab;Not Hispanic or Latino;novel;novel therapeutics;Organoids;Outcome;outreach;Paper;participant enrollment;Pathology;patient population;Patients;phase II trial;Population Sciences;programs;Publications;Race;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resistance;response;Risk;Role;Science;Scientist;senior faculty;social;social health determinants;Socioeconomic Factors;Specimen;Strategic Planning;Stratification;success;T-Cell Activation;Therapeutic;timeline;Training;treatment response;triple-negative invasive breast carcinoma;tumor immunology;tumor microenvironment;Tumor Subtype;Tumor Tissue;tumor-immune system interactions;Underrepresented Minority;willingness;Work;young woman


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: adaptive immune response;Adult;advanced breast cancer;Affect;Age;Age Years;aggressive breast cancer;anti-cancer research;Antitumor Response;Archives;Automobile Driving;Biological Factors;Blood;Blood specimen;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer care;cancer clinical trial;cancer health disparity;Cancer Patient;cancer subtypes;Cell Proliferation;Cells;Cessation of life;checkpoint inhibition;Circulation;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Combined Modality Therapy;Complex;cytokine;Demographic Analyses;design;Development;Diagnosis;Disease;disorder risk;Dose;effector T cell;efficacy evaluation;Eligibility Determination;Epigenetic Process;Equity;ERBB2 gene;Flow Cytometry;Fresh Tissue;Gene Expression;General Population;Generations;HDAC4 gene;high risk;Hispanic;Histone Deacetylase Inhibitor;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune Targeting;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;Incidence;Individual;Infiltration;insight;ipilimumab;Knowledge;Laboratories;Latino;Latino Population;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Measurement;Measures;Mediating;Metastatic breast cancer;Minority Groups;Minority Participation;minority patient;mortality;mouse model;multiple omics;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Nivolumab;Not Hispanic or Latino;novel;novel therapeutics;Organoids;Outcome;participant enrollment;Patient Care;patient population;patient stratification;Patients;peripheral blood;Phase;Phase I Clinical Trials;phase II trial;Phenotype;preclinical study;Predisposition;Production;Protocols documentation;Publishing;Race;racial difference;racial population;Recommendation;recruit;Research;Resistance;response;Role;Scientist;Socioeconomic Factors;Solid Neoplasm;Specimen;statistics;Stratification;success;Suppressor-Effector T-Lymphocytes;Survival Rate;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technology;Therapeutic;Toxic effect;treatment response;tumor;tumor microenvironment;Tumor Subtype;Tumor Tissue;tumor-immune system interactions;Underrepresented Minority;willingness;Woman;Work;young woman


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Corneal collagen crosslinking (CXL) is a cutting-edge therapy for progressive eye disease such as keratoconus, resulting in increased corneal stiffness; however, there are currently no non-contact techniques that quantitatively map corneal anisotropic elastic moduli, making it difficult to build personalized treatment plans and evaluate outcomes. Leveraging results obtained in R01 EY026532, the goal of this project is to develop a non-contact, non-invasive clinical instrument for pre-operative characterization and evaluation of post- operative outcomes in CXL treatment of keratoconus in the cornea based on Optical Coherence Tomography and Elastography. We will simultaneously map geometric (thickness and shape) and elastic properties of the cornea in vivo starting with a CXL rabbit model, continuing in healthy volunteers, and finishing in keratoconus patients pre-operatively, immediately after surgery and longitudinally post-operatively.

PI_NAMEs: PELIVANOV, IVAN  (contact);SHEN, TUENG T

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Acoustics;Air;Astigmatism;Binding;biomechanical model;Biomechanics;chemical bond;Clinical;clinical application;Clinical Research;clinical translation;Collagen;Collagen Fiber;Collagen Fibril;Cornea;Corneal Topography;Coupled;crosslink;Data;Decision Making;Diagnostic;diagnostic criteria;Digestion;Disease Progression;Elasticity;elastography;Evaluation;Eye;Eye diseases;Family suidae;follow-up;Generations;Geometry;Goals;healthy volunteer;Human;human data;Human Volunteers;Image;in vivo;in vivo imaging system;individual patient;individualized medicine;innovation;instrument;invention;Keratoconus;Laser In Situ Keratomileusis;Lasers;Lateral;Maps;Measurement;Measures;mechanical behavior;Mechanics;Methods;minimally invasive;Modeling;Monitor;Morphologic artifacts;Motion;Myopia;Operative Surgical Procedures;Ophthalmologist;Optical Coherence Tomography;Oryctolagus cuniculus;Outcome;outcome prediction;Pathological Dilatation;Patients;personalized medicine;Physiological;Population;Postoperative Period;Procedures;Property;Protocols documentation;Race;reconstruction;Research;Resistance;Resolution;Riboflavin;Robot;Sampling;Shapes;slow potential;Structure;success;surgery outcome;System;Techniques;Testing;Thick;Thinness;Time;tool;treatment planning;ultrasound;Ultraviolet Rays;Vision

PROJECT_TITLE: Noncontact in vivo guidance of corneal collagen crosslinking therapy with optical coherence tomography and acoustic micro-tapping elastography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The public-health significance of the proposed work is an advance in our understanding of the efferent half of the auditory system, or the neurons that carry signals from the brain back to the inner ear. We will use physiological, psychophysical, emissions, and computational modeling strategies to test our hypothesis that the subcortical efferent system “sharpens” or clarifies the perceptions of complex sounds, such as speech. We will also test the impact of sensorineural hearing loss on the function of the efferent system. This work will lead to novel approaches to dynamically control amplification in assistive devices such as hearing aids.

PI_NAMEs: CARNEY, LAUREL H. (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Acoustics;Address;Affect;Algorithms;Anesthesia procedures;Animals;Auditory;auditory processing;Auditory system;awake;Back;Brain;Brain Stem;Cell Nucleus;Cochlea;Cochlear nucleus;Code;Complex;Computer Models;contrast enhanced;Data;design;Ear;Efferent Pathways;Ensure;extracellular;Feedback;Frequencies;Grant;Hearing Aids;hearing impairment;hidden hearing loss;Human;Individual;Inferior Colliculus;Inner Hair Cells;insight;Knowledge;Labyrinth;lens;Masks;Measurable;Measurement;Measures;Medial;Modeling;Nerve Fibers;neural;neural model;Neurons;neurophysiology;neuroregulation;Noise;normal hearing;novel;novel strategies;Oryctolagus cuniculus;otoacoustic emission;Outer Hair Cells;Output;Perception;Performance;Peripheral;Physiological;Population;predictive modeling;Property;Psychophysics;Public Health;Reflex action;Research Design;response;Retina;Role;Self-Help Devices;Sensorineural Hearing Loss;Shapes;Signal Transduction;sound;Speech;speech in noise;Speech Intelligibility;Speech Sound;Stimulus;Study models;System;Testing;theories;Time;trapezoid body;Variant;Vision;Work

PROJECT_TITLE: Auditory Processing of Complex Sounds

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hematopoietic stem cell transplantation is a potential cure for many life-threatening blood diseases but is frequently complicated by chronic graft-versus-host disease (cGVHD). Skin changes are the most common and earliest sign, with disease assessment requiring time-consuming specialist examination. We will validate artificial intelligence technology for the automatic staging and monitoring of cGVHD from patient photographs, which can improve clinical trials and patient outcomes by replacing in-person skin assessments. 1

PI_NAMEs: TKACZYK, ERIC R (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Academic Medical Centers;Allogenic;Area;Artificial Intelligence;Assessment tool;Benchmarking;Biological;Biological Markers;biomedical informatics;Body Surface Area;Cancer Center;care providers;Chest;chronic graft versus host disease;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Consensus Development;Consumption;cost;Cutaneous;Data;Data Science;Databases;Dermatologist;Dermatology;Disease;Erythema;Ethnic Origin;Evaluation;FDA approved;follow-up;Foundations;Gender;Goals;Hematological Disease;Hematopoietic Stem Cell Transplantation;Home;Human;Immune system;improved;improved outcome;leukemia;Life;Mayo Clinic Cancer Center;Measurement;Measures;Medical;Medical Imaging;Monitor;Morbidity - disease rate;mortality;mortality risk;novel;Observational Study;Patient Care;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;Persons;Phenotype;Photography;Procedures;prognostic value;prospective;Provider;quality assurance;Relapse;Reporting;research clinical testing;response;Severity of illness;sex;Sickle Cell Anemia;Skin;skin disorder;smartphone application;Specialist;Staging;standard of care;Stem cell transplant;Surface;Technology;Telemedicine;Testing;Therapeutic Studies;Time;Training;Transplantation;transplantation medicine;United States National Institutes of Health;Universities;Validation;Visualization;Work

PROJECT_TITLE: Artificial intelligence to estimate extent of cGVHD from patient photos

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rural Health;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Depression and anxiety during and after pregnancy are common medical complications contributing to a rising maternal mortality rate. Home visiting programs can offer evidence-based interventions to improve mental health outcomes for a vulnerable pregnant population; however, barriers remain to achieving the full potential of these interventions. Our work will explore the impact of context on the implementation of a mental health intervention to provide action-based and impactful data that focuses on the lived experiences of the diverse populations served by home visiting programs in Iowa and Indiana.

PI_NAMEs: FARO, ELISSA Z (contact);RYCKMAN, KELLI K.

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: academic standard;Address;Adoption;Adverse effects;adverse maternal outcomes;adverse outcome;Affect;antepartum depression;Anxiety;arm;Attenuated;Birth;Child;Childbirth;Client;Clinical;Cluster randomized trial;Cognitive Therapy;Communities;community advisory board;Community Health;contextual factors;Data;Death Rate;depressive symptoms;Diagnosis;Disparity;disparity reduction;Divorce;Dose;Education;effectiveness/implementation hybrid;Equity;Ethnic Origin;ethnographic method;evidence base;Evidence based intervention;Family;Florida;Focus Groups;formative assessment;Geography;Goals;Health Services Accessibility;Heterogeneity;Home;Home visitation;Impairment;implementation facilitation;implementation outcomes;implementation protocol;implementation strategy;improved;Indiana;Inequity;Infant;Infanticide;Insurance Coverage;Intervention;Interview;Iowa;Lactation;Left;Lived experience;Location;low socioeconomic status;Maternal and Child Health;Maternal Mortality;maternal outcome;Measures;Mediating;medical complication;Mental Depression;Mental disorders;Mental Health;Minority;Modeling;Mothers;Outcome;Participant;Patients;perceived stress;perinatal mental health;peripartum depression;Persons;Policy Maker;Population;Population Heterogeneity;post pregnancy;Postpartum Women;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;Prenatal care;Prevalence;programs;Public Health;Qualifying;Questionnaires;Race;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;Risk Factors;Rural;rural area;secondary outcome;Severities;Social Conditions;Social support;Socioeconomic Factors;Socioeconomic Status;Special Supplemental Nutrition Program for Women, Infants, and Children;Substance abuse problem;Suicide;teenage mother;Testing;uptake;Visit;Woman;Work

PROJECT_TITLE: Can an Evidence-Based Mental Health Intervention be Implemented into Preexisting Home Visiting Programs using Implementation Facilitation?

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite advances in our knowledge of the causes and risk factors associated with periodontitis, it remains widely prevalent. The total expenditure on treating and preventing periodontal diseases is estimated in billions of dollars. Determining microbial changes that lead of periodontitis progression or periodontal stability would better inform clinicians regarding diagnosis, prevention, treatment and monitoring.

PI_NAMEs: BITTINGER, KYLE ;TELES, FLAVIA ROCHA (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Affect;Aftercare;aging population;bacterial community;biobank;bioinformatics tool;Biological;Biological Markers;bone loss;Calibration;Cardiovascular Diseases;Clinical;Clinical Data;clinical practice;clinically relevant;comorbidity;Computational Biology;Consumption;cost;Coupled;cytokine;Data;Diagnosis;Disease Progression;dysbiosis;Environment;Event;Evolution;Expenditure;experience;Funding;Future;Generations;Genomics;Gingiva;Gingival Crevicular Fluid;Goals;Health Transition;host-microbe interactions;Human;Immune response;Immunologics;Immunology;improved;Individual;Infection;Inflammation;Inflammatory;insight;Intervention;Knowledge;Lead;Measures;Mediating;Mediator;Metabolic;metabolomics;microbial;Microbial Biofilms;microbial community;microbial host;microbial signature;Microbiology;microbiome;microbiome analysis;microbiome composition;microbiota;microorganism;Modeling;Monitor;multidisciplinary;multiple omics;National Institute of Dental and Craniofacial Research;Natural History;Participant;Pathogenesis;Patients;Periodontal Diseases;Periodontitis;Periodontium;Persons;Positioning Attribute;predictive modeling;prevent;Prevention;Prevention strategy;prospective;Prospective Studies;Resource Allocation;Respiratory Tract Infections;Risk;Risk Factors;Sampling;Shotgun Sequencing;Site;subgingival microbiome;Testing;Time;Tissues;tool;Tooth Loss;Tooth structure;Translational Research;treatment response;United States National Institutes of Health;Validation

PROJECT_TITLE: Defining Dysbiosis and Mechanisms of Periodontitis Progression and Stability

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Digestive Diseases;Genetics;Liver Disease;Lung;Orphan Drug;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative: Alpha-1-antitrypsin (AAT) deficiency (AATD) related chronic obstructive pulmonary disease (COPD) is an aging sensitive inherited disease with onset and progression resulting from misfolding of variant (mutant) forms of AAT in the endoplasmic reticulum (ER) leading to gain-of-toxic aggregation in the liver and subsequent loss-of- function of neutrophil elastase (NE) inhibitory activity in serum and lung tissue- triggering progressive liver and lung failure by mid-to-late decades of life. This proposal addresses how specific branches of the protein folding machinery (proteostasis) involving the unfolded protein response (UPR) ATF6 and IRE1/XBP1s signaling pathways can be manipulated by chemical activators to protect the patient from disease in response to the diverse AAT variants encoded in the genome of the world-wide population by combined chemical, experimental and computational Gaussian process (GP) regression machine learning tools. We hypothesize that ATF6 and IRE1/XBP1s signaling pathways can be used to develop a new class of AAT folding correctors for nearly the entire spectrum of the AAT variant patient population, providing new mechanistic insights into the role of AAT in human liver and lung health and disease.

PI_NAMEs: BALCH, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Affect;Age Years;Aging;Alleles;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Amyloidosis;ATF6 gene;Automobile Driving;Biology;Bronchiectasis;Cells;Cellular Stress;Cessation of life;Chemicals;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Pathways;Collaborations;Collection;cost;Data;design;Diagnosis;Disease;Disease Management;Disease Progression;drug development;effective therapy;Effectiveness;end stage disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Etiology;experimental study;FDA approved;Functional disorder;gain of function;Genetic;Genetic Diseases;genetic disorder diagnosis;genetic variant;Genome;Genotype;GRP78 gene;Health;Heat-Shock Proteins 70;Hepatocyte;Hereditary Disease;Human;improved;Individual;individual responsibility;Infusion procedures;Inherited;innovation;insight;Intervention;Leukocyte Elastase;Life;Link;Liver;Liver diseases;Liver Failure;loss of function;Lung;Lung Diseases;lung failure;lung health;Machine Learning;Maps;Medicine;Modeling;Molecular Chaperones;mutant;Mutation;novel therapeutic intervention;Output;paralogous gene;Pathology;patient population;Patients;Phenotype;Plasma;polymerization;Polymers;Population;Prize;Process;programs;Property;Protease Inhibitor;protein folding;protein misfolding;Proteins;proteostasis;Publications;Research;Research Personnel;Resolution;response;Role;sensor;Serum;Severity of illness;Signal Pathway;Signal Transduction;small molecule;Solid;Stress;Structure of parenchyma of lung;System;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Training;Transplantation;Trypsin;Variant;XBP1 gene

PROJECT_TITLE: Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Project Narrative The G4 next generation sequencing (NGS) platform will render state-of-the-art capacity to replace the existing expired /obsolete Affymetrix microarray GeneAtlas. The G4 NGS platform is urgently needed to propel biomedical research capacity on genetic elements of health disparities and training of faculty and students on NGS technologies.

PI_NAMEs: REAMS, ROMONIA RENEE (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Accreditation;Affect;Agriculture;Award;Bachelor's Degree;Biomedical Research;Cells;Classification;college;Complex;Computers and Advanced Instrumentation;Core Facility;cost;Disadvantaged;Disparity population;Doctor of Philosophy;Doctor's Degree;Education;Equipment;equipment acquisition;expiration;Faculty;flexibility;Florida;Funding;fungus;genome analysis;genome sequencing;Genomics;Goals;graduate student;Grant;higher education;Institution;instrument;instrumentation;interest;Laboratory Research;Marketing;Master of Science;Mechanics;Mentors;Microarray Analysis;microbiome;Minority Groups;minority health;minority health disparity;Molecular;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation sequencing;Notification;Pharmacologic Substance;Pharmacy facility;Phase;Phylogenetic Analysis;programs;Prokaryotic Cells;Request for Applications;Research;Research Activity;research facility;Research Personnel;Research Project Grants;Research Support;Research Training;research vision;Retirement;Running;Schools;Science;sequencing platform;Services;skills;Source;Students;System;Taxonomy;Technology;Time;Training;Underserved Population;Universities

PROJECT_TITLE: Singular Genomics ; G4 Sequencing Platform


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: NARRATIVE Skeletal muscle atrophy is a serious consequence of many diseases and conditions for which there are no effective pharmaceutical therapies. The E3 ubiquitin ligase, MuRF1, is associated with multiple forms of atrophy and deletion can lead to partial muscle sparing. Identification of the in vivo substrates targeted by MuRF1 for ubiquitylation is a critical next step in advancing our understanding of the mechanisms by which MuRF1 regulates skeletal muscle mass, and could lead to the identification of new therapeutic targets.

PI_NAMEs: BODINE, SUE C (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Affinity;Aging;Area;Atrophic;Cardiovascular Diseases;Coupled;Cytoplasm;Data;Denervation;Desmin;Deuterium Oxide;Disease;drug candidate;drug development;effective therapy;Electroporation;Fiber;Gastrocnemius Muscle;Glycylglycine;Hindlimb;Human;Immobilization;in vivo;insight;Intermediate Filament Proteins;Investigation;Kidney Failure;Knockout Mice;Knowledge;Label;Length;Link;Liquid Chromatography;Literature;Lysine;Malignant Neoplasms;Maps;Measures;Mediating;Modification;multicatalytic endopeptidase complex;Mus;Muscle;Muscle Fibers;muscle form;Muscular Atrophy;Nerve Degeneration;new therapeutic target;novel;Outcome;overexpression;Pharmacologic Substance;Plasmids;prevent;Prevention;Process;protein degradation;Proteins;Proteomics;Publications;Reporting;response;Rest;Rodent;Role;Sarcomeres;selective expression;Site;Skeletal Muscle;skeletal muscle wasting;Striated Muscles;tandem mass spectrometry;Testing;therapy development;Thick Filament;tibialis anterior muscle;Time;Transcriptional Regulation;Ubiquitin;ubiquitin-protein ligase;Up-Regulation;Validation

PROJECT_TITLE: MuRF1 substrates and mechanisms of skeletal muscle atrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Kidney Disease;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This project is designed to investigate how calcium build-up (calcification) in brain blood vessels produces injury to the brain. Calcified arteries have limited capacity to react normally (constrict and dilate) and this incapacity contributes to impairment of blood flow to the brain. We will delineate the extent of brain injury due to calcified blood vessels in autopsy human brain and in a mouse model by studying a high-risk population (chronic kidney disease in aging) and take the first steps to reduce brain vascular calcification with specific drug treatment.

PI_NAMEs: FISHER, MARK J (contact);LAU, WEI LING ;MAGAKI, SHINO D

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Adult;age related;aged;Aging;aging population;aging related disease;Area;Arteries;arteriole;Attention;Autopsy;Biometry;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain imaging;Brain Injuries;brain parenchyma;calcification;Calcium;cerebral microbleeds;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chronic Kidney Failure;clinical development;Cognition;Cognitive;cognitive performance;Complex;constriction;design;Disease;Elements;epidemiology study;experience;Functional disorder;Hemorrhage;high risk;high risk population;Human;human study;Hypertension;imaging study;Impaired cognition;Impairment;improved;Injury;insight;Intracranial Atherosclerotic Disease;Investigation;Ischemia;ischemic injury;Knowledge;Literature;Medial;Mediator;Microvascular Dysfunction;mouse model;Mus;Nephrology;Neurobiology;neuropathology;neurovascular;novel;Patients;Pattern;Pharmacotherapy;Pilot Projects;Population;prevent;Process;Publishing;Qualifying;Reaction;Research;Research Design;Risk Factors;Role;Role Concepts;Source;Stroke;stroke neurology;stroke risk;Study models;synergism;targeted therapy trials;targeted treatment;Therapeutic Trials;therapy design;Vascular calcification;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Diseases;vascular injury;Work

PROJECT_TITLE: Neurovascular Calcification: Consequences and Treatment

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative This project aims to refine and evaluate EXPO (EXecutive function Play Opportunities), a new caregiver- mediated intervention designed to support the development of executive function in children with Down syndrome. In this R61/33, we will continue the intervention development process by transforming EXPO into an adaptive intervention, with modifications for children who show greater degrees of developmental delay and who may respond more slowly to EXPO. We will then test the restructured EXPO adaptive intervention with a two- arm, Singly Randomized Trial that will evaluate the effectiveness of EXPO pathways.

PI_NAMEs: FIDLER, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: acceptability and feasibility;Accounting;adaptive intervention;Address;Age;arm;Behavioral;Caregivers;Child;Childhood;Clinical;Cognitive;cognitive reappraisal;Communities;community based participatory research;Data;design;Development;Developmental Delay Disorders;Down's Syndrome;early childhood;Early Intervention;effective intervention;Effectiveness;effectiveness evaluation;Elements;Employment;evidence base;executive function;Feedback;Focus Groups;follow-up;formative assessment;Foundations;Goals;Heterogeneity;Home;Individual;Individual Differences;infancy;Intervention;Italy;Laboratories;Language;life span;Linguistics;Measures;Mediating;Modification;Motor;Neuronal Plasticity;novel;novel therapeutics;Outcome;Outcome Measure;Participant;Pathway interactions;personalized approach;Phase;Phenotype;Pilot Projects;Play;Population;Preparation;primary caregiver;Process;programs;prototype;Proxy;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;response;Schools;Science;Self Determination;Shapes;skill acquisition;skills;social;standardize measure;Structure;Subgroup;Syndrome;Testing;Therapeutic Trials;therapy design;therapy development;trend;usability

PROJECT_TITLE: Executive Function Intervention for Young Children with Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE In collaboration with the Altino Ventura Foundation, RTI International will continue to evaluate the impact of severe congenital Zika syndrome (CZS) on the development and well-being of 187 children and their families as the children enter middle childhood and enroll in school, focusing on the evolution of structural features of CZS (brain, ocular, orthopedic), long-term medical, developmental and mental health outcomes for children and their families, and predictors of these outcomes. Through this research, we will better understand the natural history of CZS and any factors that may be associated with specific health outcomes, which will help inform and prepare the global community to better support children and families currently living with CZS, potential future cases of CZS, and children impacted by other conditions with similar clinical findings.

PI_NAMEs: VENTURA, CAMILA ;WHEELER, ANNE CAROLINE (contact)

PROJECT_TERMS: Address;Affect;behavioral outcome;Birth;bone imaging;Brain;Brain imaging;Brazil;Buffers;Case Study;Child;Child Development;Child Support;Childhood;Clinical;Clinical assessments;cohort;Collaborations;Communities;community based participatory approach;congenital zika syndrome;COVID-19 pandemic;Data;design;Development;Diagnosis;disability;Disease Outbreaks;early adolescence;early childhood;Electroencephalography;Endocrine;Enrollment;Environment;Environmental Risk Factor;Evolution;Family;Foundations;functional outcomes;Funding;Future;future outbreak;Growth;Health;Heart Rate;heart rate variability;Image;imaging study;improved;improved outcome;Incidence;Individual;infancy;innovation;International;Knowledge;Lesion;Longitudinal Studies;Magnetic Resonance Imaging;Mediation;Mediator;Medical;Mental Health;Metabolic;middle childhood;Modeling;Monitor;National Institute of Child Health and Human Development;Natural History;North Carolina;novel;ocular imaging;Orthopedics;Outcome;outcome prediction;participant retention;Pattern;Pelvis;Personal Satisfaction;Pituitary Gland;Positioning Attribute;prenatal exposure;Prognosis;prospective;Protocols documentation;Publications;Reporting;Research;Research Personnel;Retina;Risk Factors;Roentgen Rays;Sampling;Schools;Services;Severities;skeletal;skills;Standardization;statistics;Subgroup;sustained attention;Syndrome;Therapeutic Uses;Time;transmission process;Universities;Update;Vertebral column;viral transmission;Work;Zika Virus

PROJECT_TITLE: Clinical progression and predictors of outcomes in congenital Zika syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Diabetes;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: NARRATIVE This proposal will use novel MRI methodologies to investigate the multicomponent vascular, glymphatic and meningeal lymphatic cerebral waste clearance (CWC) systems in aged diabetic animals, with and without therapeutic intervention. Elucidation of the contributions among the component CWC systems will provide mechanistic insight into their roles in mediating cognitive dysfunction in the aged diabetic animal.

PI_NAMEs: JIANG, QUAN  (contact);ZHANG, LI

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Achievement;Adult;aged;Aging;Amyloid beta-Protein;Animals;aquaporin 4;Biological Markers;Blood Vessels;Brain;brain endothelial cell;brain magnetic resonance imaging;brain parenchyma;Cells;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Clinic;clinical translation;Cognitive;Cognitive deficits;cognitive function;cognitive recovery;Contrast Media;Data;Detection;detection sensitivity;diabetes management;Diabetes Mellitus;diabetic;Disease;Disease Outcome;Disease Progression;Drainage procedure;Elderly;Evaluation;exosome;extracellular vesicles;fluorescence imaging;glymphatic system;Image;imaging modality;Imaging Techniques;Immune;Impaired cognition;Impairment;improved;Individual;insight;intercellular communication;iron oxide;Lymphatic System;lymphatic vessel;Magnetic Resonance Imaging;Measurement;Mediating;Meningeal lymphatic system;Metabolic Clearance Rate;Metabolic Diseases;Methodology;Methods;MicroRNAs;middle age;Molecular;nanosized;Nervous System Disorder;Neurodegenerative Disorders;novel;novel strategies;Outcome;Pathway interactions;Patients;Play;Population;Predisposition;Rattus;Research;response;Role;Severities;superparamagnetism;System;Testing;Therapeutic Intervention;Translations;two-photon;Validation;Vascular Diseases;vascular factor;Vascular System;Venous;wasting

PROJECT_TITLE: Imaging cerebral waste clearance responses during exosome treatment of diabetes

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Prevention;Regenerative Medicine

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Coronary heart disease is the leading cause of death in the U.S, and patients have a high risk for cardiac arrhythmias after surviving a myocardial infarction. Spatial heterogeneity of sympathetic nerves, including denervation, is a major contributor to post-infarct cardiac arrhythmias. The studies proposed here will restore cardiac sympathetic nerves using novel therapeutics and will determine the diverse mechanisms by which reinnervation prevents arrhythmias and alters cardiac inflammation.

PI_NAMEs: HABECKER, BETH A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: A kinase anchoring protein;Acetylcholine;Adrenergic Receptor;American;Arrhythmia;Axon;beta-adrenergic receptor;Binding;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiac repair;Cause of Death;Cell membrane;Cells;Chemicals;Chondroitin Sulfate Proteoglycan;Cicatrix;Clinical Research;Coculture Techniques;Complex;Consensus;coronary artery occlusion;Coronary heart disease;Data;Denervation;DLG1 gene;Electrophysiology (science);Fluorescence Resonance Energy Transfer;Ganglionectomy;Genetic;Genetic Models;Heart;Heart Block;heart damage;heart function;Heterogeneity;high risk;Human;Image;Immune;Immune response;Infarction;Inflammation;Inflammatory;Injury;innovation;Intervention;Isoproterenol;Label;Life;Macrophage;Mass Spectrum Analysis;Methods;Muscle Cells;Myocardial Infarction;Myocarditis;Nerve;nerve supply;Neurons;neurotransmission;neurotrophic factor;noradrenergic;Norepinephrine;novel;novel therapeutics;Operative Surgical Procedures;Patients;Peripheral;Pharmaceutical Preparations;phosphodiesterase IV;Phosphoric Monoester Hydrolases;Post-Translational Protein Processing;Preparation;prevent;Process;Protein Tyrosine Phosphatase;Proteome;reinnervation;Risk;risk prediction;Role;Side;sigma receptors;Signal Transduction;Site;sudden cardiac death;Sulfate;Sympathectomy;Sympathetic Nervous System;Testing;Therapeutic;tool;transmission process;Ventricular Arrhythmia

PROJECT_TITLE: Neurotrophins and post-infarct plasticity in cardiac sympathetic neurons

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Narrative Treatment of schizophrenia with antipsychotics must be closely monitored to avoid side effects arising from excessive use of medication. We are developing a new PET radiotracer which can be used to determine a patient’s response to antipsychotic treatment. This will ultimately improve patient`s lives, and make a greater impact on drug therapy and management of psychosis.

PI_NAMEs: SUBBURAJU, SIVAN  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: accurate diagnosis;Affinity;Agonist;Amphetamines;Animal Model;antagonist;Antipsychotic Agents;atypical antipsychotic;Behavioral;Behavioral Model;behavioral study;Binding;Binding Proteins;Biodistribution;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain region;Chemistry;Chronic;Clinical;Clinical Research;Corpus striatum structure;cost;Data;density;Development;Diagnostic;Disease;Disease Management;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;dosage;Dose;Economic Burden;Ensure;Etiology;Evaluation;Experimental Designs;experimental study;Exposure to;Family;Fluorine;Formulation;Goals;Hepatocyte;Human;Image;imaging study;improved;in vivo;in vivo evaluation;Incidence;Investigational Drugs;Investigational New Drug Application;Label;Ligands;Macaca;Macaca mulatta;manufacture;Measures;Mental disability;mesolimbic system;Metabolic;Methods;microPET;Microsomes;Modeling;Monitor;Monkeys;Morbidity - disease rate;nanomolar;Nervous System;Neurotransmitters;nonhuman primate;Organ;Outcome;Parkinson Disease;patient response;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiological;Plasma;Plasma Proteins;Positron-Emission Tomography;pre-clinical;preclinical study;predictive marker;Prevalence;prevent;Prognosis;programs;Protocols documentation;Psychoses;psychotic;Public Health;Publishing;Radiolabeled;radiotracer;Rattus;receptor;receptor density;Receptor Down-Regulation;receptor downregulation;receptor function;reduce symptoms;Reproducibility;research clinical testing;Resistance;response;Rodent;Rodent Model;Safety;Schizophrenia;side effect;socioeconomics;Specificity;Stimulus;Symptoms;Tardive Dyskinesia;Testing;Therapeutic;Titrations;tool;Toxicology;Translations;transmission process;treatment response;Up-Regulation;Visualization

PROJECT_TITLE: Imaging the Functional State of the D2high Receptor in drug induced dopamine supersensitivity in schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Genetic diversity is a key factor underlying heterogenous disease states of tuberculosis. However, current mouse models fail to incorporate both genetic and phenotypic diversity. This proposal leverages diverse but reproducible Collaborative Cross mouse strains, bacterial reporters of infection and novel host-pathogen genetic mapping strategies to mechanistically define loci underlying disease tolerance. Overall, these novel and synergistic strategies will define new models of disease tolerance and set the roadmap for systematically interrogating host-pathogen genetic interactions underlying tuberculosis.

PI_NAMEs: SMITH, CLARE MARGARET (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: antimicrobial;Award;Body Weight decreased;Chromosome Mapping;Chronic;chronic infection;cohort;Data;design;Disease;disease model;Ensure;Exhibits;Failure;Genetic;Genetic Variation;Genotype;Human;Immune response;Immunity;Immunologics;Inbred Strains Mice;Infection;insight;Lung;Mediator;microbial;Modeling;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;novel;pathogen;Pathology;Pathway interactions;Phenotype;Predisposition;prevent;rational design;Reporter;Reproducibility;Resistance;Tissues;trait;Tuberculosis;tuberculosis immunity;Variant;Work

PROJECT_TITLE: Dissecting the genetic basis of protective immunity to tuberculosis in diverse hosts


PHR: NARRATIVE In the last few decades clinical radiation therapy (RT) technology has developed dramatically, with intensity modulated RT (IMRT) representing one of the most significant advances, however, these advancements have not translated to preclinical small animal RT, which largely resembles the state of clinical RT in the 1970s in terms of its use of simple circular/rectangular beam geometries, uniform beam intensities, and lack of high quality 3D target dose conformality. Consequently, small animal RT studies do not allow for accurate 3D dose targeting or simulate the radiobiological, radioimmunological, hypoxic and toxicity environment of modern human RT. The goal of this proposed project is to create a novel 3D printed compensator IMRT (3DPC-IMRT) system that is low cost, easy to implement, and can allow high mouse throughput.

PI_NAMEs: WIERSMA, RODNEY  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;3D Print;Abdomen;Address;Adoption;Advisory Committees;Algorithms;Anatomy;Animal Model;Animals;Area;Biological;Biomedical Research;Clinical;clinical implementation;Collimator;Complex;Conformal Radiotherapy;contrast enhanced;cost;cost effective;cost effectiveness;Databases;design;Development;Disease;Dose;Engineering;Environment;Equipment;Evaluation;Filament;Future;Gamma-H2AX;Geometry;Goals;Human;human disease;human subject;Hypoxia;Immunologics;improved;in vivo;Intensity-Modulated Radiotherapy;invention;Iodine;Maintenance;Mechanics;Methodology;Methods;model organism;Modernization;Monitor;Motor;mouse model;Mus;novel;Organ;Outcome;Pancreatic Ductal Adenocarcinoma;Performance;Plant Leaves;pre-clinical;pre-clinical research;Printing;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radio;Radiobiology;Reporting;Reproducibility;Research;Rotation;Scanning;Shapes;Site;Speed;Stains;Standardization;Study models;success;Survival Analysis;System;Techniques;Technology;Testing;Thick;Time;Tissues;Toxic effect;Training;Translating;Translations;treatment planning;Vertebral column;virtual

PROJECT_TITLE: Development of a 3D printed small animal intensity modulated radiation system


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Palliative Care;Physical Activity;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Individuals with Down syndrome (DS) experience premature aging and high rates of Alzheimer’s disease (AD) and associated declines in physical function which are associated with increased caregiver burden. Interventions to increase physical activity may improve or maintain physical function in aging adults with DS and reduce burden on their caregivers, who are often parents facing their own age-related functional declines. This project will adapt an evidence-based intervention developed for use in typically developed adults with AD which combines physical activity and caregiver training in behavioral symptom management to the needs of those with DS and evaluate the potential for the adapted intervention to improve functional and health parameters in adults with DS and reduce caregiver burden.

PI_NAMEs: MOSCONI, MATTHEW W;NOLLEN, NICOLE L (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Activities of Daily Living;Adoption;Adult;Age;age related;Aging;Alzheimer's Disease;Behavioral Symptoms;career;career development;Caregiver Burden;caregiver education;Caregivers;Cause of Death;Clinical Investigator;Clinical Research;Data;Dementia;dementia care;Development;disability;Down's Syndrome;efficacy evaluation;Evidence based intervention;exercise intervention;experience;functional decline;functional independence;Funding;Health;Home visitation;improved;Incidence;Individual;Institution;Intellectual functioning disability;Intervention;Knowledge;Life Expectancy;Maintenance;Mentors;Parents;Pathology;Physical activity;Physical Function;Physical Performance;Physiological;Premature aging syndrome;Prevalence;psychosocial;Public Health;Randomized;remote delivery;Research;Safety;Sampling;skills;symptom management;therapy design;Training;Training Support;Translational Research;United States National Institutes of Health;usability

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE To decrease symptom burden and maximize their quality of life, inflammatory bowel disease (IBD) patients need to master skills that facilitate self-management—the daily behaviors individuals must perform to keep their illness under control, minimize its impact on their physical health, and cope with comorbid or resulting psychological symptoms. In alignment with the National Institute of Health’s mission to improve people’s health and quality of life, this study proposes to develop an intervention that is designed to support patients with active IBD in self- management and improve their care, symptoms, and quality of life. This approach will provide insights for feasible and acceptable self-management interventions with adaptability to diverse IBD populations.

PI_NAMEs: COHEN-MEKELBURG, SHIRLEY ANN (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Abdominal Pain;acceptability and feasibility;Affect;American;Award;Behavior;Behavior Therapy;Behavioral;Biological;career;Caring;Characteristics;Chronic Disease;Clinic Visits;Clinical;Clinical Investigator;Clinical Management;Clinical Research;Clinical Trials;Cognitive Therapy;Collaborations;comorbidity;comparison intervention;coping;Data;Data Collection;design;Development;digital;digital delivery;Direct Costs;Disease;Disease Management;Doctor of Medicine;Drops;Drug Prescriptions;Education;efficacy study;efficacy trial;emotional distress;Enrollment;Environment;Evaluation;evidence base;Evidence based intervention;experience;feasibility trial;Feedback;Fostering;Foundations;Future;Gastroenterologist;Gastroenterology;gastrointestinal;Goals;Health;Healthcare;Hemorrhage;HIV;Hospitalization;Impact evaluation;improved;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Institution;Intervention;intervention delivery;intervention refinement;Intervention Studies;Interview;Knowledge;Low Back Pain;Mediator;medication compliance;Mentorship;Methods;Michigan;Mission;Modeling;Monitor;Motivation;Outcome;participant enrollment;participant retention;Patient Preferences;Patient-Focused Outcomes;Patients;Perception;Persons;physical conditioning;pilot test;pilot trial;Population;primary endpoint;Process;Production;Protocols documentation;psychologic;psychological symptom;psychosocial;Psychosocial Factor;Qualitative Methods;Quality of life;Randomized, Controlled Trials;Recording of previous events;Rectum;reduce symptoms;Reporting;Research;Research Personnel;Research Training;satisfaction;Self Management;skills;Structure;success;Symptom Burden;Symptoms;Target Populations;Testing;theories;therapy design;therapy development;Training;treatment as usual;treatment planning;United States National Institutes of Health;Universities

PROJECT_TITLE: Developing a Self-Management Intervention to Improve Health Outcomes for Patients with Inflammatory Bowel Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: NARRATIVE Short organ preservation time imposes severe constraints on transplantation, contributes to reduced organ availability and high discard rates, diminishes organ quality while exacerbating graft rejection, and limits the length and quality of life for transplant recipients. The overarching goal of this project is to develop means for organ preservation in cryogenic temperature, with a focus on the liver due to its high priority need. This project focuses on an innovative approach of creating more favorable conditions for cryopreservation by elevating the pressure surrounding the organ.

PI_NAMEs: RABIN, YOED  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute Liver Failure;Adverse effects;Amplifiers;Artificial Liver;Attention;authority;Behavior;Benchmarking;biobank;Biocompatible Materials;Biological Preservation;cell injury;Cell Transplantation;Communities;computerized tools;cryobiology;cryogenics;Cryopreservation;Cryoprotective Agents;Crystallization;Data;design;Development;Devices;Dialysis procedure;drug discovery;efficacy evaluation;Engineering;engineering design;Evaluation;Experimental Models;experimental study;Follow-Up Studies;Foundations;Freezing;Goals;Graft Rejection;Hepatocyte;Human;Ice;improved;Injury;innovation;Knowledge;left ventricular assist device;Length;Link;Literature;Liver;liver preservation;liver transplantation;Location;Methodology;Mission;Modeling;mortality;novel strategies;operation;Organ;organ allocation;Organ Donor;Organ Preservation;Organ Procurements;Organ Transplantation;Outcome;Patients;Perfusion;Physics;preservation;pressure;Process;Protocols documentation;Pump;Quality of life;Rattus;Regulation;Research Proposals;response;Risk;Running;Scientific Advances and Accomplishments;Services;Source;Specimen;System;Systems Analysis;Systems Integration;Technology;Temperature;Text;Time;Tissue Preservation;tool;Toxic effect;Toxicology;transplant model;Transplant Recipients;Transplantation;Uncertainty;United Network for Organ Sharing;Validation;Water;Work

PROJECT_TITLE: Developing pressure-modulated means for high-subzero liver preservation

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Severe Acute Respiratory Syndrome-associated Coronavirus 2 (SARS-CoV-2) infection is associated with a dysregulated cytokine response (a “cytokine storm”) that is thought to underlie severe disease. While the cell types, genes, and viral factors that initiate this aberrant response are incompletely understood, tools to investigate pulmonary alveolar cell type-specific phenotypes are also limited. To gain a deeper understanding of events precipitating the SARS-CoV-2-associated cytokine storm and other fundamental aspects of alveolar immune responses, we will establish innovative mouse models that integrate cell type-specific targeted gene editing with unbiased pooled CRISPR/Cas9 library screening approaches in both infected respiratory epithelial cells and alveolar macrophages in close proximity.

PI_NAMEs: ORVEDAHL, ANTHONY W (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Adenovirus Vector;Adenoviruses;airway epithelium;Alveolar;Alveolar Cell;Alveolar Macrophages;Alveolus;antagonist;Area;Autophagocytosis;Award;Biological Process;cell type;Cells;Complex;Coronavirus;COVID-19 cytokine storm;CRISPR library;cytokine;cytokine release syndrome;Cytosol;Degradation Pathway;Development;Disease;Dissection;Epithelial Cells;Event;functional genomics;Genes;Granulocyte-Macrophage Colony-Stimulating Factor;Human;Immune response;Immunity;In Vitro;in vivo;Incubators;Infection;Inflammation;Inflammatory Response;Injury;innovation;Intravenous;Libraries;Lung;Lysosomes;Membrane;Methods;Modeling;mouse model;Mus;Myeloid Cells;neonate;Nonstructural Protein;pathogen;Pathway interactions;Peptide Initiation Factors;Phenotype;Point Mutation;Population;Precipitating Factors;Predisposition;prevent;receptor;recombinant virus;reconstitution;respiratory;response;restraint;Role;SARS-CoV-2 infection;screening;Signal Transduction;Site;stem cells;Syndrome;System;Testing;Tissues;TNF gene;tool;Transgenic Organisms;United States National Institutes of Health;vector;Viral;Viral Pathogenesis

PROJECT_TITLE: Alveolus as Incubator: Functional Genomic Dissection of the Host Response to SARS-CoV-2 Infection.


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative IPUMS NHGIS data are advancing fundamental knowledge about health and population dynamics. NHGIS directly supports rigorous and reproducible research on health, disease, and development across the lifespan by simplifying access to the geographic census data that are essential for measuring key social determinants of health. NHGIS data provide the denominators required for the spatial analysis of epidemiological and demographic change; it is impossible to interpret the incidence of disease or death without knowing the population at risk.

PI_NAMEs: MANSON, STEVEN M.;SCHROEDER, JONATHAN P (contact);VAN RIPER, DAVID C

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: advanced system;Age;Alaska Native population;American;American Indian Population;application programming interface;Area;base;career;Censuses;Cessation of life;Characteristics;Code;Collection;Communities;Community Surveys;Confidence Intervals;Consult;cost;Data;data access;data infrastructure;Data Scientist;Data Set;data sharing;data standards;Database Management Systems;Databases;design;Development;Disclosure;Disease;Disparity;Distributed Systems;diverse data;Education;Epidemiology;Ethnic Origin;Funding;Geographic Information Systems;Geography;Goals;Health;Hour;improved;Incidence;Income;infant morbidity/mortality;innovation;Investments;Knowledge;life span;Link;Maps;maternal morbidity;Measurement;Measures;Metadata;metropolitan;mortality;National Institute of Child Health and Human Development;Neighborhoods;Noise;outreach;outreach program;Personal Satisfaction;Population;Population Database;Population Dynamics;population health;Population Research;Populations at Risk;privacy protection;Puerto Rico;Pythons;Race;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Scientist;Series;sex;Small-Area Study;social health determinants;socioeconomics;Source;spatiotemporal;Standardization;statistics;Surveys;System;systems research;terabyte;Time;tool;Training;Training Programs;Tribes;Uncertainty;virtual;web site;webinar

PROJECT_TITLE: National Spatiotemporal Population Research Infrastructure

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Obsessive Compulsive Disorder (OCD) is a chronic and debilitating psychiatric condition associated with functional impairment and decreased quality of life. Exposure and Response Prevention (ERP) is the gold standard behavioral treatment for OCD. However, few Veterans receive this treatment within the VHA. There is a lack of research evaluating barriers and facilitators to the implementation of ERP in VHA. With respect to the implementation of ERP, mixed-methods economic evaluations can aid stakeholders by evaluating whether implementing ERP is worth the investment in costs both quantitatively, through cost-effectiveness analysis, and qualitatively, via interviews with individuals who can provide context-specific information on the resources required for implementation. The parent trial to this supplement seeks to evaluate the effectiveness of ERP compared to a control condition, Stress Management Training (SMT), on Veteran functioning. The current supplement proposes to add a mixed-methods economic evaluation of ERP for OCD in Veterans.

PI_NAMEs: FLETCHER, TERRI LYNN (contact)

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;Affect;Algorithm Design;Algorithms;Anxiety;anxiety management;Behavior Therapy;burden of illness;career;Caring;Chronic;Clinic;clinical practice;compulsion;contextual factors;Continuity of Patient Care;cost;Cost Analysis;cost comparison;cost effective;cost effective intervention;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Data;data warehouse;Development;Disabilities experience;Disease;Distress;economic evaluation;Educational Intervention;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Evaluation;evidence base;Evidence based intervention;experience;Exposure to;Fright;Functional impairment;Funding;Future;Goals;Health;health care service;health related quality of life;Hybrids;Image;Impairment;implementation evaluation;implementation facilitators;implementation/effectiveness;incremental cost-effectiveness;Individual;Intervention;intervention cost;intervention delivery;Interview;Investments;K-Series Research Career Programs;Learning;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methods;microcosting;Modeling;Obsession;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Outcome;parent grant;parent project;Parents;Personnel Management;Population;preference;Prevalence;Prevention;primary outcome;Process;Provider;Psyche structure;Psychotherapy;Qualitative Evaluations;Qualitative Methods;Quality of life;Quality-Adjusted Life Years;Recording of previous events;Reporting;Research;Research Personnel;Resources;response;Risk;secondary outcome;stress management;Suicide attempt;Symptoms;telehealth;Thinking;Time;Training;Unemployment;Veterans;Veterans Health Administration;Wit;Work

PROJECT_TITLE: A Mixed-Methods Economic Evaluation of Exposure and Response Prevention in Veterans with Obsessive-Compulsive Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 DEIR-W (01)]


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: NARRATIVE Hypertension is the leading cause of cardiovascular diseases worldwide. This study aims to investigate the role of endothelial progranulin and its autocrine actions on regulating endothelial function and blood pressure. By using cutting-edge technology such as genetically modified mice, gain and loss-of-function experiments, and best methods to study vascular function and blood pressure, we are expecting to place progranulin as novel therapeutic target for cardiovascular diseases associated with hypertension.

PI_NAMEs: BRUDER, THIAGO  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adult;Affect;angiotensin hypertension;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Anti-Inflammatory Agents;autocrine;Autocrine Communication;Automobile Driving;Biological Availability;Biology;Blood Pressure;blood pressure control;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;cationic antimicrobial protein CAP 37;Cell Physiology;Characteristics;Clinical;Data;Development;Disease;Dose;Drops;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Experimental Models;experimental study;Functional disorder;Gatekeeping;Gene Modified;Genetic;Hypertension;hypertension treatment;hypertensive;In Vitro;in vivo;Knockout Mice;Knowledge;Length;loss of function;Mediating;Mesenteric Arteries;Mesentery;Methods;Modeling;Molecular;mouse model;Mus;NADPH Oxidase 1;Neurodegenerative Disorders;new therapeutic target;Nitric Oxide;novel;novel therapeutics;organ injury;Outcome;overexpression;oxidation;Patients;Peptidyl-Dipeptidase A;PGRN gene;pharmacologic;Predisposition;Production;Proteins;Publishing;Reactive Oxygen Species;receptor;Recombinants;Research;Role;Series;Stimulus;Technology;Testing;Therapeutic;tool;United States;Vascular Diseases;vascular injury;Vasodilation;Wild Type Mouse

PROJECT_TITLE: Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Narrative Our recent publications demonstrated that M1 macrophages play a crucial role in controlling both the infection and inflammatory responses. Our preliminary studies suggest that M1 macrophages are trained (have memory). We will test this hypothesis and potential therapeutic strategies that favor this response by in vivo analysis using a unique set of clinically relevant mouse models and viruses.

PI_NAMEs: GHIASI, HOMAYON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Acute;Adoptive Transfer;Affect;Anterior eyeball segment structure;Apoptosis;Autophagocytosis;CCL2 gene;CD8-Positive T-Lymphocytes;Cells;Characteristics;Chromatin;Chronic;clinically relevant;clinically significant;Complex;conditional knockout;Cornea;CXCL9 gene;Data;Disease;Disease Progression;Dose;Equilibrium;Exhibits;Eye;Eye Development;Eye diseases;Family;Funding;Gene Activation;Generations;Genes;Glycoproteins;Guanosine Triphosphate Phosphohydrolases;Herpes stromal keratitis;Herpesvirus 1;Homeostasis;Host Defense Mechanism;Immune;immune cell infiltrate;Immune response;Immunity;improved;In Vitro;in vivo;in vivo evaluation;Infection;Infiltration;Inflammation;Inflammatory Response;innovation;insight;Interferon Type II;Interleukin-15;latent infection;Longevity;Macrophage;Maintenance;Mediating;Memory;Modeling;Mononuclear;mouse model;Mouse Strains;multiple myeloma M Protein;Mus;novel;Pathogenesis;Pathologic;Phagocytes;Phagocytosis;Phenotype;Play;Population;prevent;Prevention;Primary Infection;Property;Publications;Publishing;reactivation from latency;Reporting;Resolution;response;Role;Series;Simplexvirus;Testing;Therapeutic;therapeutic target;Tissues;Training;Up-Regulation;Viral;Viral Load result;Virus;Virus Diseases;Virus Replication;Vision;Wild Type Mouse

PROJECT_TITLE: Role of Macrophages in control of Ocular HSV

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative: Antibiotic treatment failure is a major global public health threat. In addition to acquiring antibiotic resistance, bacteria can transiently reprogram their phenotype, which bolsters their ability to survive high-dose antibiotic treatment. This work will enhance our knowledge of how interactions with a host's microbiome impact bacterial responses and susceptibly to different classes of antibiotics, which can potentially improve our ability to treat recurrent infections.

PI_NAMEs: MOK, WENDY W.K. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Adjuvant;Aftercare;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Cells;chronic infection;Communities;Cues;Development;Dose;effective therapy;Environmental Risk Factor;Exposure to;Goals;host microbiome;improved;innovation;Knowledge;Maps;Mediating;metabolomics;microbiome;microorganism interaction;Modern Medicine;Molecular;novel;Outcome;pathogen;persistent bacteria;Pharmaceutical Preparations;Phenotype;Population;Predisposition;programs;Public Health;recurrent infection;Refractory;Resistance development;response;Staphylococcus aureus;Techniques;transcriptomics;Treatment Failure;Treatment Protocols;treatment strategy;Work

PROJECT_TITLE: Mapping polymicrobial interactions that modulate antibiotic persistence