NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE. Social bonds with friends and loved ones are critical to our physical and mental health; however, we currently lack a basic understanding of the neural circuits that underly this fundamental human behavior. In this study, we use cutting-edge spatial transcriptomics and circuit manipulations to understand how the hippocampus, a region critical for social memory, contributes to social attachment in the monogamous prairie vole. We will test the role of the social neuropeptide oxytocin in this region and uncover new signaling mechanisms underlying hippocampal regulation of behavior, ultimately driving us towards mechanistic therapies for numerous psychiatric disorders that are accompanied by the deterioration of social interactions.

PI_NAMEs: LONG, KIMBERLY LORRAINE PAGE (contact)

PROJECT_TERMS: Affective;Agonistic Behavior;antagonist;Area;Automobile Driving;Behavior;behavioral outcome;behavioral response;Binding;Bioinformatics;Biological Assay;BRAIN initiative;California;career development;cell type;Child;Complex;Deterioration;Development;Exhibits;Experimental Designs;Exposure to;Faculty;Female;Fluorescent in Situ Hybridization;Foundations;Friends;Goals;hippocampal subregions;Hippocampus;hormone regulation;Human;Image;Immediate-Early Genes;Individual;insight;Institution;Intervention;Link;loved ones;Maintenance;male;Maps;Mediating;Mediator;Memory;Mental disorders;Mental Health;Mentors;Mentorship;Microtus;model organism;Molecular;Molecular Profiling;Monitor;Mus;neural;neural circuit;Neuroendocrine Cell;neuromechanism;Neuromodulator Receptors;Neuropeptides;neuroregulation;Neurosecretory Systems;novel;Oxytocin;Oxytocin Receptor;Pair Bond;Parents;Partner in relationship;Pattern;Phase;physical conditioning;Physiology;Play;prairie vole;preference;receptor;receptor expression;receptor function;Receptor Signaling;Regulation;Research;research and development;Resource Development;response;Role;San Francisco;sex;Signal Transduction;single nucleus RNA-sequencing;social;social attachment;Social Behavior;social cognition;Social Interaction;Spatial Distribution;Steroid Receptors;System;Testing;tool;Training;transcriptomics;Universities;Vasopressin Receptor;Work

PROJECT_TITLE: Oxytocin receptor signaling modulates social attachment via hippocampal CA2/3 function


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Rare Diseases;Scleroderma

ORG_CITY: New York

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: Despite multiple clinical trials of immunosuppressive and anti-fibrotic agents, there are no FDA-approved drugs to treat the severe skin fibrosis caused by systemic sclerosis (SSc). Preliminary studies suggest there is a subset of patients who harbor activated fibroblasts and immune cells in their skin, and those patients may be most likely to benefit from immunosuppression. The overarching study goal is to unravel immune cell-fibroblast interactions in SSc and Very Early Onset of Systemic Sclerosis (VEDOSS) to map disease phases where treatment may be of most benefit, test a histology-derived model for classifying patients most likely to improve, and yield insights into the very earliest phases of SSc.

PI_NAMEs: LAKIN, KIMBERLY SHOWALTER (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Actins;Age;Antibodies;antifibrotic treatment;Autoantibodies;Autoimmune Diseases;B-Cell Activation;B-Lymphocytes;Bioinformatics;Biological;Biopsy Specimen;career;career development;Categories;CD34 gene;cell type;Cells;Classification;Clinical;Clinical Data;clinical examination;Clinical Research;Clinical Trials;clinically significant;Cluster Analysis;cohort;Collagen;Complex;Consensus;Contracture;Cutaneous;Cutaneous sclerosis;Cytometry;Data;Dermal;Dermatopathology;design;Diffuse;digital;Disease;early onset;FDA approved;Fibroblasts;Fibrosis;Fingers;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Genes;genetic signature;genetic variant;Goals;Guidelines;high risk;Histologic;Histology;Image;Immune;immune activation;Immunohistochemistry;Immunology;Immunosuppression;improved;indexing;Individual;individualized medicine;Infiltration;Inflammation;Inflammatory;insight;Institution;Interferon Type I;Interferons;K-Series Research Career Programs;Laboratories;longitudinal analysis;Machine Learning;machine learning method;Maps;Measures;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;Molecular;molecular phenotype;monocyte;Mononuclear;mortality risk;MS4A1 gene;Operative Surgical Procedures;Oranges;Organ;Outcome;Pain;Pathogenesis;Pathway interactions;Patient Care;patient oriented research;patient subsets;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Positioning Attribute;pre-clinical;Production;professor;Race;Recommendation;Research;Research Personnel;response;Rheumatism;Rhubarb food;Sampling;Services;Severities;sex;skills;Skin;skin biopsy;skin fibrosis;Smooth Muscle;Special Hospitals;Stromal Cells;success;Systemic Scleroderma;Testing;tool;Training;Training Programs;transcriptome sequencing;transcriptomics;Translational Research;trial enrollment;Up-Regulation;Visualization

PROJECT_TITLE: Discovering immune drivers of fibroblast polarization andrecovery in systemic sclerosis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Heart Disease;Lung;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative The incidence of acute pulmonary embolism is high (~400,000 cases per year), and residual shortness of breath (Post-PE Syndrome), primarily driven by deconditioning and anxiety, is common. This study will examine whether a specific, daily set of exercise instructions (by text or email) for 8 weeks can decrease disability after hospital discharge for acute pulmonary embolism. By studying this cost-effective intervention, we will learn whether a home-based rehabilitation program could reduce disability, improve quality of life, and decrease healthcare utilization (costs).

PI_NAMEs: LACHANT, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acceleration;Accelerometer;actigraphy;Acute;Address;Adherence;Anticoagulation;Anxiety;automated analysis;Award;Awareness;Behavioral;Biomedical Engineering;Biometry;Cardiac;Cardiac rehabilitation;Cardiology;career development;Caring;clinical care;clinical investigation;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Computer software;Control Groups;Convalescence;cost;cost effective;cost effective intervention;Counseling;Data;Data Set;Decentralization;deconditioning;design;Development;Diagnosis;Diagnostic tests;Digital biomarker;disability;Disease;Drops;Drug Industry;Dyspnea;Educational process of instructing;Electronic Mail;Electronics;Embolism;Enrollment;Ethnic Origin;European;Exclusion;Exercise;exercise program;exercise rehabilitation;Exercise Therapy;Feedback;follow-up;Foundations;frontier;Functional disorder;Funding;Goals;Guidelines;health care service utilization;Heart;Heart Diseases;Heart Rate;heart rate monitor;Home;Hospitalization;Hospitals;impaired functional status;improved;Incidence;Individual;Inpatients;insight;Instruction;Intervention;K-Series Research Career Programs;Label;Learning;Length of Stay;Location;Lung;Lung Diseases;Measures;Medical History;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;Morbidity - disease rate;Myocardial Infarction;novel;Outcome;Outcome Measure;pandemic disease;participant enrollment;Patient Outcomes Assessments;Patient Self-Report;Patients;Physical activity;Physical Capacity;Physicians;Physiological;Physiology;programs;Prospective Studies;Publishing;Pulmonary Embolism;Pulmonary Heart Disease;pulmonary vascular disorder;Quality of life;Questionnaires;Race;Randomized;Recommendation;recruit;rehabilitation strategy;Rehabilitation therapy;remote monitoring;Research;Research Personnel;Research Project Grants;research study;Residual state;response;Right Ventricular Dysfunction;Right Ventricular Function;Role;Safety;safety assessment;Scientist;secondary analysis;sedentary lifestyle;sex;Shortness of Breath;Societies;Socioeconomic Factors;symptomatic improvement;Syndrome;Technology;Testing;Text;Time;tool;Training;treatment response;United States National Institutes of Health;Universities;Walking;wearable device;Wrist

PROJECT_TITLE: Electronically Delivered Home Rehabilitation to Improve Symptoms and Activity After Pulmonary Embolism

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Overreliance on habit strategies can be driven by environmental factors, like stress exposure, or genetic disruptions, and contributes to a range of psychiatric conditions, including autism. However, the mechanisms by which stress promotes habit is unknown. This project will identify the cell-type- and subregion-specific effects and interactions of stress and autism-associated genetic alteration on the striatal circuitry that controls habits.

PI_NAMEs: GIOVANNIELLO, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 16p11.2;Amygdaloid structure;Animals;ASD patient;autism spectrum disorder;Behavior;Behavior Control;Behavior Therapy;behavioral phenotyping;Brain;Calcium;cell type;Cells;Characteristics;Chronic stress;Corpus striatum structure;Data;Data Analyses;Decision Making;Doctor of Philosophy;Dopamine D1 Receptor;Dorsal;Electrophysiology (science);endophenotype;Environment;Environmental Risk Factor;Equilibrium;Evaluation;Exposure to;Foundations;Funding;Future;gene environment interaction;Genes;Genetic;genetic manipulation;Goals;Habits;Human;Image;imaging approach;improved;in vivo;in vivo calcium imaging;insight;Knowledge;Learning;learning outcome;maladaptive behavior;Measures;Mentors;microdeletion;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;Mutation;neuromechanism;Neurons;open source;optogenetics;Outcome;Pathologic;Pathway interactions;Phase;Population;Postdoctoral Fellow;Predisposition;premature;programs;prospective;Research;Resolution;response;Rewards;Rodent;Role;skills;Slice;Stress;stress reduction;Synapses;synergism;System;Technical Expertise;Techniques;Technology;Testing;Therapeutic;Training;Work

PROJECT_TITLE: Revealing the neural mechanisms of amygdala-striatal control of stress-induced habits

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (05)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Infectious Diseases;Sepsis

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Sepsis is a major cause of death among immune-compromised cancer patients such as those undergoing chemotherapy. The proposed study investigates acupuncture, a novel modality in management of sepsis, for its role in reducing death or intensive care unit admission among those patients. This research can potentially give us a new tool for how we prevent and treat sepsis, a common treatment-related toxicity in cancer patients.

PI_NAMEs: DENG, GARY E (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Acupuncture Therapy;Admission activity;Adrenal Glands;Adult;American;Animal Model;Animals;Antibiotic Therapy;Biological Markers;Blinded;Cancer Patient;cancer survival;Caring;Catecholamines;Cause of Death;Cessation of life;chemotherapy;China;Clinical;clinical practice;common treatment;Consent;Critical Illness;cytokine;Data;Death Rate;Deterioration;Development;Dopamine;Epinephrine;Event;Health;hemodynamics;high risk;high risk population;Hospitalization;Hospitals;hypoperfusion;Immune;improved;improved outcome;Inflammation;Inflammatory;inflammatory marker;Informed Consent;Infusion procedures;innovation;Inpatients;Intensive Care Units;Interferon Type II;Interleukin-6;Intervention;intervention delivery;Intervention Studies;IV Fluid;Knowledge;Life;Measures;Mechanical ventilation;Mediating;Medical;Medicine;meetings;Meta-Analysis;Modality;Monitor;Morbidity - disease rate;mortality;multiorgan damage;Nature;Neurons;New York;Norepinephrine;novel;Organ;Outcome;Outcome Assessment;Patients;phase 3 study;phase II trial;Plasma;Population;prevent;primary endpoint;Production;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;recruit;Research;Risk;Role;Sample Size;screening;Sepsis;septic patients;Septic Shock;standard care;study population;systematic review;Tissues;TNF gene;tool;Translating;Treatment-related toxicity;Vasoconstrictor Agents

PROJECT_TITLE: Acupuncture to Improve Outcomes in Patients with Sepsis: a Randomized Controlled Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (O2)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative UNMC researchers are leaders in cancer, infection and inflammation, neuroscience, cardiovascular disease, and aging. Clinical expertise abounds with national recognition for primary care training, rural practice, and handling the toughest infectious diseases. In this proposal, our MD-PhD program seeks to create the Nebraska LEAD MSTP to train diverse, curious, and caring students to become physician scientists equipped with the clinical and research tools to change medicine.

PI_NAMEs: MOTT, JUSTIN L. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Medical Scientist Training Program at the University of Nebraska

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_DEPT: GENETICS

PHR: Project Narrative: This predoctoral training program is designed to train the next generation biomedical researchers, hence it is directly relevant to public health. The mission of this program is to address the critical need to equip experimental biologists with quantitative and analytical capabilities, effective communication, and leadership skills in the data-rich field of biomedical sciences. Trainees graduating from this program are expected to adopt well to the rapidly changing landscape of big data in experimental research and thrive well as biomedical scientists.

PI_NAMEs: DUDLEY, ANDREW T (contact);GUDA, CHITTIBABU

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Critical Analysis of Data-Rich Networks for Biomedical Scientists in Training.

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Infectious Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE We continue to lack vaccines for many pathogens of public health importance, including herpes simplex virus-2 (HSV-2), human immunodeficiency virus-1 (HIV-1), and tuberculosis (TB). In many infections of public health importance, the mucosal barrier is the portal of pathogen exposure, yet the regulation of mucosal immunity is incompletely understood. Completion of this proposal will provide insight into regulation of the anti-viral mucosal immune response and how pathogen clearance can be achieved while preserving barrier tissue integrity.

PI_NAMEs: VICK, SARAH C (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Biological Assay;Cell Maturation;cell motility;Cell Physiology;Cells;chemokine;Clinical;cytokine;Data;Dendritic Cells;Disease;draining lymph node;Flow Cytometry;HIV-1;HIV-2;Homeostasis;Homing;Human;Human Characteristics;Human Herpesvirus 2;Immune response;Immunity;Immunologic Memory;Immunology;immunopathology;immunoregulation;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Innate Immune System;insight;Killer Cells;Knowledge;Link;Location;Measures;Memory;Memory impairment;Migration Assay;mouse model;Mucosal Immune Responses;Mucosal Immunity;mucosal site;mucosal vaccine;Mucous Membrane;Mus;Natural Immunity;Nature;Outcome;pathogen;pathogen exposure;peripheral tolerance;Phenotype;Play;Population;preservation;Productivity;Public Health;Publishing;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Research;Residencies;response;Role;single-cell RNA sequencing;T-Cell Depletion;Tissues;Transcript;Tuberculosis;vaccine strategy;Vaccines;Vagina;Viral;Virus Diseases;Work

PROJECT_TITLE: Regulatory T cell coordination of the mucosal NK cell response during viral infection

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARATIVE Ascariasis (roundworm) is the most common helminth infection globally and causes severe life-long illness in children. In a non-native animal model, ascariasis leads to the development of chronic lung disease. This proposal will use a “One Health” approach to develop a novel, translational animal model to evaluate Ascaris- induced chronic lung disease in a native host.

PI_NAMEs: WEATHERHEAD, JILL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Abattoirs;Address;Adult;Affect;Anatomy;Animal Model;Area;Ascariasis;Ascaris;Ascaris lumbricoides;Ascaris suum;biomass fuel;Body Weight decreased;Cells;Child;Childhood;Chronic;Chronic lung disease;Clinical;Clinical Trials;Communities;Coughing;Cross Infection;cytokine;Data;design;Development;Disease Management;Domestic Pig;Dyspnea;Economics;egg;Environment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Family suidae;Flow Cytometry;hatching;Health;Healthcare;helminth infection;Helminths;Histopathology;Human;human disease;human model;IL17 gene;immune activation;Immune response;immune RNA;immunogenic;Immunologics;Immunology procedure;Immunotherapy;improved;Infection;infection rate;Ingestion;Interleukin-13;interleukin-22;Interleukin-4;Interleukin-5;Interleukin-6;Intervention;Intestines;Larva;Lesion;Life;Life Cycle Stages;Link;Liver;Livestock;low and middle-income countries;Lung;Lung Compliance;lung volume;migration;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nematoda;new therapeutic target;non-Native;novel;novel vaccines;Nursery Schools;Oral Ingestion;Organ;Parasites;Pathway interactions;Persons;Phase;Physiologic Monitoring;Physiology;porcine model;Poverty;prevent;preventive intervention;Public Policy;Pulmonary Emphysema;pulmonary function;Resolution;Resources;Respiratory Tract Infections;Risk Factors;School-Age Population;Structure;System;Technology;Therapeutic Intervention;transcriptome sequencing;Weight Gain

PROJECT_TITLE: Development of a novel translational porcine model of Ascaris-induced chronic lung disease.

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Primary Health Care;Rare Diseases;Tuberculosis

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: SOCIOS EN SALUD SUCURSAL PERU

PHR: This study aims to develop and evaluate new simple tools to facilitate decision-making by primary care physicians managing children and adolescents exposed to tuberculosis in low- and middle-income countries. Having these tools in places where there is no access to x-ray machines or there are not enough highly trained health personnel should make it possible to improve health care for these children and adolescents, preventing the appearance of new tuberculosis cases and reducing deaths.

PI_NAMEs: PUMA, DANIELA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 19 year old;9 year old;Adolescent;Adult;Age;Appearance;Artificial Intelligence;Bacteriology;Cause of Death;Cessation of life;Characteristics;Chest;Child;Child health care;Childhood;clinical decision-making;clinical risk;cohort;Cohort Studies;Communicable Diseases;Communities;computer aided detection;Computer software;Country;COVID-19;Data;Decision Making;demographics;Development;diagnostic tool;Disease;Disease Progression;Evaluation;Exposure to;Funding;Goals;Health;Health care facility;Health Personnel;Health Policy;health training;high risk;HIV Seronegativity;Home;Household;Image;improved;Incidence;indexing;Investigation;Knowledge;Lesion;low and middle-income countries;Medical History;Morbidity - disease rate;mortality;Nutritional;Patient Self-Report;Patients;Performance;Persons;Peru;Peruvian;Pharmaceutical Preparations;Population;Predisposition;prevent;Preventive therapy;Preventive treatment;Primary Care;Primary Care Physician;primary care setting;Primary Health Care;Radiologic Finding;Reading;Recommendation;Reference Standards;Research;research clinical testing;Rest;Risk;ROC Curve;Roentgen Rays;Sampling;screening;screening program;Sensitivity and Specificity;Severities;software systems;Symptoms;System;Test Result;Thoracic Radiography;tool;Tuberculosis;United States National Institutes of Health;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Tools to facilitate preventive therapy for children and adolescents in primary care.

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_DEPT: NUTRITION

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Less than a third of United States youth meet physical activity guidelines, with lower activity levels found among girls, racial minorities, and those living in rural areas. The proposed research aims to develop, tailor, and examine the impact of a tailored Boys & Girls Clubs (BGC) sport sampling and physical literacy intervention on rural girls’ physical activity levels. This work is significant in that addressing barriers to physical activity and sport via BGC can reduce gender, racial, and geographic disparities in youth activity levels.

PI_NAMEs: JOHNSON, ASHLEIGH MARIE (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: actigraphy;Address;Adolescent;Adult;Age;aged;Automobile Driving;boys;burnout;California;Childhood;Cognition;Collaborations;community engaged research;community intervention;Competence;County;culturally appropriate intervention;Development;Disparity;disparity reduction;Drops;Educational Curriculum;efficacy evaluation;efficacy trial;Elements;Ensure;Equity;Ethnic Origin;experience;Face;Family;feasibility testing;Feedback;Female Adolescents;fitness;Funding;Gender;gender disparity;geographic disparity;girls;Goals;Guidelines;healthy weight;Hispanic;Hispanic Populations;human centered design;Human Resources;ideation;implementation science;improved;Individual;innovation;Instruction;Intervention;intervention delivery;Interview;Knowledge;Leadership;Learning;learning strategy;Life Cycle Stages;literacy;Measures;meetings;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Modification;Muscle;Outcome;Parents;Phase;phase 1 designs;phase 2 designs;Physical activity;Population;programs;prototype;Race;racial disparity;racial minority;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Rural;rural area;Rural Population;rural setting;rurality;Sampling;Self Determination;Site;social;Sports;Stress;Structure;suburb;Testing;theories;therapy development;Training;Underserved Population;United States;Work;Youth;youth sports

PROJECT_TITLE: Development and feasibility testing of a Boys & Girls Clubs' sports intervention to promote physical activity in rural girls: Girls PLAY

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative:  Recent work has emphasized the importance of RPE metabolism in retinal function and health. However, little is known about the cell biology of mitochondria and its interaction with other organelles and cytoskeleton network in the RPE. The proposed study aims to employ state-of-the-art methods, including high-speed live-cell imaging to investigate how RPE mitochondrial dynamics and organelle interaction change in health and in disease.

PI_NAMEs: HULTGREN, NAN WU (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Academia;Actins;Address;Adopted;Advisory Committees;Affect;aged;Algorithmic Analysis;Behavior;Biological;Biological Assay;Biology;Blood;Blood capillaries;Blood Vessels;career;career development;Cell Communication;Cell Line;cell replacement therapy;Cells;Cellular biology;Choroid;Choroideremia;Collaborations;Custom;Cytoskeleton;Dependence;Deterioration;Disease;disease model;Ecosystem;Electron Microscopy;Energy-Generating Resources;Environment;Epithelial Physiology;Equilibrium;Etiology;Event;experience;Eye diseases;fatty acid oxidation;Foundations;Functional disorder;Future;Future Teacher;Genes;Genetic;Genus Hippocampus;Glucose;Glycolysis;Goals;Growth Factor;Health;Homeostasis;Human;Image;imaging approach;imaging modality;Impairment;induced pluripotent stem cell;insight;Ions;Knockout Mice;lipid metabolism;Lipids;live cell imaging;Mass Spectrum Analysis;Metabolic;Metabolism;Methods;Mission;Mitochondria;Modeling;Molecular;Molecular Motors;Morphology;Motility;Motor Activity;multi-photon;Mus;mutant;National Eye Institute;neuron loss;Neurons;new therapeutic target;novel;organ on a chip;Organelles;Organoids;Oxidative Phosphorylation;Pathogenesis;patient derived induced pluripotent stem cells;Perfusion;peroxisome;Phagocytes;Phagocytosis;Phagosomes;pharmacologic;Photoreceptors;Physiological;Positioning Attribute;Postdoctoral Fellow;preference;prevent;programs;Protocols documentation;Qualifying;Reporting;Research;Resources;Respiration;Retina;Retinal Degeneration;Role;Scientist;Signal Transduction;Site;Solid;Source;Speed;stable isotope;Structure of retinal pigment epithelium;Surface;Synapses;System;Testing;Time;tool;Training;ultra high resolution;Universities;Vision;Visualization;Water;Work

PROJECT_TITLE: Understanding how mitochondrial interaction with other organelles in the retinal pigment epithelium (RPE) affect its function in the outer retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Gulf War Veterans’ Illnesses (GWVI) is a multi-symptom illness that plagues a section of the veterans who were deployed during the Persian Gulf War named as Operation Desert Shield and Desert Storm. The veterans complain of a persistence of gastrointestinal disturbances, chronic fatigue, pain and cognitive defects that has been difficult to manage at the clinics. The goal of this clinical trial is to determine if a Butyrate formulation that consists of butyric acid as calcium and magnesium derivatives in a single oral capsule taken twice a day is effective in increasing the quality of life for veterans with GWI. The secondary outcome will focus on the drug's role in (a) restoring gut microbiome and virome (that have been found altered in GWI veterans),(b) decreasing gastrointestinal disturbances (constipation, diarrhea, pain) (c) decreasing chronic fatigue , (d) decreasing systemic inflammation such a blood levels of proinflammatory cytokines and (d) a decrease in neurocognitive deficiencies.

PI_NAMEs: CHATTERJEE, SAURABH  (contact);KLIMAS, NANCY GRACE;TUTEJA, ASHOK K

PROJECT_TERMS: 3-Dimensional;Anti-Inflammatory Agents;associated symptom;attenuation;Bacteria;bacteriome;Biological Markers;Blood;Boston;Butyrates;Butyric Acids;Calcium;capsule;Chronic;chronic pain;Cities;Clinic;clinical efficacy;clinical outcome measures;Clinical Research;Clinical Trials;Cognitive deficits;cognitive function;Complex;Constipation;Controlled Clinical Trials;Coughing;cytokine;Data;Diarrhea;Disease;Doctor of Medicine;Double-Blind Method;drug candidate;dysbiosis;efficacy evaluation;Encapsulated;enema administration;Exanthema;Exhibits;experience;Fatigue;Fermentation;Fibromyalgia;Food Additives;Formulation;Frequencies;Gastroenterologist;Gastroesophageal reflux disease;gastrointestinal;gastrointestinal function;General Population;Geography;Goals;Gulf War;Gulf War veteran;gut homeostasis;gut microbiome;gut microbiota;gut-brain axis;Health;HMGB1 gene;Home;host microbiome;IL6 gene;Illness impact;Impaired cognition;improved;improved outcome;Inflammatory;Intestinal permeability;Intestines;Irritable Bowel Syndrome;Laboratories;Link;Location;Magnesium;Measures;Medical center;mental function;Metabolism;Metagenomics;microbial;microbiome;microbiome alteration;microbiome analysis;microbiome signature;Molecular;mouse model;Names;Neurocognitive;neuroinflammation;Nutraceutical;Oral;Outcome;Outcome Measure;Pain;Participant;Patient Self-Report;Patients;Pattern;Peripheral;Persian Gulf;Persian Gulf Syndrome;Pharmaceutical Preparations;Pharmacology;Phase;Phase II Clinical Trials;Physical Function;Placebo Control;placebo group;Placebos;Population;preclinical study;primary endpoint;primary outcome;Pruritus;Pulmonary Inflammation;Quality of life;Questionnaires;Randomized;recruit;reduce symptoms;Research;Research Design;restoration;Role;Safety;safety testing;secondary endpoint;secondary outcome;Serum;Severities;Severity of illness;Site;Sleep;Sleep disturbances;Sodium Chloride;Symptoms;systemic inflammatory response;targeted treatment;Testing;Thyroid Gland;TNFRSF1A gene;treatment arm;treatment choice;treatment group;Treatment Protocols;Universities;Urine;Utah;Veterans;virome;Volatile Fatty Acids;Work

PROJECT_TITLE: Microbiome targeted oral butyrate therapy in Gulf War multisymptom illness


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This proposal is relevant to public health because, while many pathologies of amyotrophic lateral sclerosis (ALS) have long been studied, effective treatments remain elusive. Abnormalities in motoneuron excitability remain the most tightly linked to disease pathogenesis, yet both HYPER- and HYPO-excitability changes have been seen in motoneurons at various disease stages and in multiple lines of ALS mice. The proposed work will investigate how the under-studied hypo-excitability mechanisms contribute to the unstable MN environment, in order to fill an important gap in knowledge and verify a novel drug target for stabilization of motoneuron excitability and prevention of motoneuron death.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: 3-Dimensional;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Anatomy;Cell Death;Cell model;Cells;Cessation of life;Complex;Computer Models;Data;Dementia;Development;Disease;Drug Targeting;effective therapy;Electrophysiology (science);Environment;Event;excitotoxicity;Exhibits;experimental study;FDA approved;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Goals;Immunohistochemistry;Ion Channel;Knowledge;Kv2.1 channel;Life;Link;Measures;Mediating;Modeling;Motor Neurons;Mus;Muscle fasciculation;Nerve Degeneration;neurobiotin;neuronal excitability;Neurons;neuroprotection;new therapeutic target;novel;Paralysed;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Play;predictive modeling;prevent;Prevention;Property;Public Health;reconstruction;Regulation;Riluzole;Role;Severities;Spinal;Stains;Subcellular Anatomy;Symptoms;Testing;theories;therapeutic target;Western Blotting;Work

PROJECT_TITLE: Mechanisms Underlying Excitability Regulation of Motoneuron Types in ALS

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Chemical modifications to DNA impact biological function, and when they deviate from the norm, it can lead to disease. This study aims to develop biotechnological methods to precisely map these epigenetic DNA modifications under challenging scenarios, when either sample amount is limited or diverse modifications within a sample are clustered. These methods will advance our understanding of developmental biology and lay the groundwork for future applications in the study of disease progression.

PI_NAMEs: LOO, CHRISTIAN ETHAN (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Alleles;base;Benchmarking;Biological;Biological Process;Biology;Biotechnology;Biotin;bisulfite;bisulfite sequencing;career;cell type;Chemicals;Code;Coupled;Cytosine;Cytosine deaminase;Deaminase;Deamination;demethylation;Detection;Development;Developmental Biology;Disease;Disease Progression;DNA;DNA Modification Process;early embryonic stage;Embryonic Development;Engineering;Enzymes;Epigenetic Process;epigenome;Fellowship;FOXP3 gene;Future;Gene Activation;Gene Expression;Gene Silencing;Genome;Genomic DNA;Germ Cells;Goals;Hypermethylation;Immobilization;imprint;Individual;innovation;insight;Knockout Mice;Libraries;Link;mammalian genome;Maps;method development;Methods;Modification;Mus;Nature;Neurons;novel;Pathway interactions;Pennsylvania;Phase;Phenotype;Play;pluripotency;Positioning Attribute;preservation;prevent;Reaction;Regulatory T-Lymphocyte;Research;Resistance;Resolution;retention rate;Role;Sampling;Shapes;Solid;Structure of primordial sex cell;Substrate Specificity;Time;tool;Training;Universities;Validation;Work

PROJECT_TITLE: Advancing Epigenetic Sequencing Through Solid-Phase Enzymatic Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The COVID-19 pandemic has painfully demonstrated that K-12 school safety during a respiratory viral pandemic has a crucial role in community viral transmission control, children’s and teachers’ welfare, and optimal social functioning. With the overall objective of understanding K-12 school experience and safety strategies during the pandemic, we aim to identify and review the current research on the topic by performing a scoping review (Aim 1); to examine school stakeholder (individuals-level) and school administrative (institutional-level) perceptions, concerns, and experience through stakeholder longitudinal surveys (Aim 2A) and administrator interviews (Aim 2B); to examine the implementation outcomes of an institutional-level Bluetooth Digital Contact Tracing intervention through questionnaires and focus group interviews (Aim 3). With COVID-19 unlikely to vanish, and schools constantly threatened by respiratory viruses, the proposed study offers holistic insights into how to effectively keep schools safe during the current and future pandemics.

PI_NAMEs: LI, DAN  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Adherence;Administrator;Antibodies;Attitude;Behavior;Behavioral;Bluetooth;career;Case Study;Child;Clip;Code;Communities;community transmission;Connecticut;Contact Tracing;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 vaccination;Crowding;current pandemic;Data;data cleaning;Data Collection;design;Devices;digital;Doctor of Philosophy;Emergency Situation;Engineering;Environment;Equipment and supply inventories;Event;experience;Faculty;falls;Fatigue;Focus Groups;Foundations;Future;future pandemic;Goals;Group Interviews;high risk;high school;High School Student;Hospitals;Household;Human Resources;implementation evaluation;implementation outcomes;improved;Individual;Infection;Influenza;influenza virus vaccine;insight;Institution;Institutional Review Boards;Intervention;Interview;Knowledge;Literature;Longitudinal Surveys;Maps;member;Methods;Middle School Student;Nature;Nurses;operation;Output;Pain;pandemic disease;Parents;Participant;Perception;Performance;Persons;Phase;Physicians;Policies;policy recommendation;prevent outbreaks;Prevention;Preventive measure;Prisons;Privatization;Process;programs;Protocols documentation;Publishing;Questionnaires;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Relaxation;Research;respiratory;respiratory virus;response;Role;Safety;safety practice;SARS-CoV-2 transmission;satisfaction;school environment;Schools;Scientist;Series;Social Functioning;Social Interaction;Societies;Statistical Data Interpretation;Structure;Students;Surveys;teacher;Training;Transcript;Vaccination;vaccine hesitancy;Vaccines;Variant;Viral;viral outbreak;viral pandemic;viral transmission;Virus;welfare

PROJECT_TITLE: Enhancing K-12 School Safety During a Respiratory Viral Pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In light of unsettlingly high rates of adverse newborn outcomes – such as perinatal mortality, low birthweight, and preterm birth – in the United States, evidence-based approaches to improve maternity care are vital. Medicaid provider incentives for provision of immediate postpartum long-acting reversible contraception and antepartum fetal surveillance offer two potential strategies to enhance outcomes via improvements in birth spacing and early detection of fetal distress, respectively. In the absence of a robust evidence base, the proposed research will rigorously estimate the impact of each strategy on newborn outcomes to inform data- driven clinical practice around postpartum contraception and antepartum surveillance.

PI_NAMEs: VATSA, RAJET  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adoption;adverse outcome;Affect;antenatal;Area;Birth;Birth Intervals;Birth Rate;Caring;Cesarean section;Characteristics;Clinical;clinical practice;Clinical Skills;clinically relevant;Contraceptive methods;Data;Death Rate;Dedications;design;Discipline of obstetrics;Disparity;Early Diagnosis;Electronic Health Record;empowerment;Environment;Equity;ethnic minority;Ethnic Origin;Evaluation;evidence base;experience;Face;Fees;Fellowship;fetal;Fetal Death;Fetal Distress;Generations;geographic difference;Goals;Guidelines;Health;Health Care Costs;health data;Health Disparities Research;health disparity;Health Services Accessibility;healthy pregnancy;High Risk Woman;Hospitals;Image;improved;improved outcome;Incentives;Income;Individual;Inequity;Inpatients;Integrated Health Care Systems;Intervention;Left;Light;Live Birth;Location;Low Birth Weight Infant;Low income;low socioeconomic status;Machine Learning;machine learning method;Masks;Massachusetts;Medicaid;Mentorship;Methods;Modality;mortality;multidisciplinary;National Institute of Child Health and Human Development;neonatal health;Newborn Infant;Outcome;Patients;payment;Perinatal mortality demographics;Policies;Policy Analysis;Population;postpartum contraception;Postpartum Period;Pregnancy;Pregnancy Interval;Premature Birth;Prenatal care;Professional Organizations;programs;Provider;Quasi-experiment;Race;racial minority;Reproductive Health;Research;Research Priority;Risk;skill acquisition;Small for Gestational Age Infant;stillbirth;Subgroup;System;tool;Training;trend;United States;Variant;Veins;Vulnerable Populations;Woman

PROJECT_TITLE: Leveraging Causal Inference and Machine Learning Methods to Advance Evidence-Based Maternal Care and Improve Newborn Health Outcomes


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Myelin is essential for proper neuronal function and health, and disruption of myelin leads to neurological symptoms in diseases such as multiple sclerosis and peripheral neuropathies. Mounting evidence has demonstrated that the endocannabinoid system can serve as a potential target for future therapeutics, through its role in regulating myelination. This proposal will uncover the specific roles of the cannabinoid receptors in the biology of the cells that make myelin, using genetic and pharmacological approaches as well as innovative photopharmacological tools in zebrafish.

PI_NAMEs: MIRAMONTES, TANIA G (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 2-arachidonylglycerol;Affect;Agonist;Amides;anandamide;Animal Model;Axon;axonal degeneration;Binding;Calcium;cannabinoid receptor;Cannabinoids;Cell Lineage;Cell Physiology;Cells;Cellular biology;Cellular Membrane;Central Nervous System;CNR1 gene;CNR2 gene;covalent bond;CRISPR/Cas technology;Demyelinating Diseases;Demyelinations;Development;Dimensions;Disease;Dorsal;Endocannabinoids;endogenous cannabinoid system;Enzymes;Event;Experimental Genetics;fatty acid amide hydrolase;Fatty Acids;Foundations;Future;G protein-coupled inwardly-rectifying potassium channel;G-Protein-Coupled Receptors;Genetic;genetic analysis;genetic approach;genome editing;Genomics;glial cell development;GPR55 receptor;Health;Image;Impairment;in vivo;innovation;interest;Larva;Ligands;Light;Lipids;lipoprotein lipase;loss of function;Mediating;Membrane;Metabolic;Methods;Modeling;Molecular;Monoacylglycerol Lipases;Motility;Multiple Sclerosis;mutant;Myelin;Myelin Basic Proteins;myelination;NAPE-PLD;Nervous System;Nervous System Disorder;Neuroglia;Neurologic Symptoms;Neuronal Dysfunction;Neurons;neuroregulation;novel;oligodendrocyte lineage;oligodendrocyte myelination;oligodendrocyte progenitor;Oligodendroglia;Optics;palmidrol;Peripheral Nervous System;Peripheral Nervous System Diseases;pharmacologic;Physiological;precursor cell;prevent;protein expression;Proteins;Proteomics;Rattus;receptor;Receptor Activation;receptor expression;Receptor Signaling;reduce symptoms;remyelination;Resolution;Role;Schwann Cells;Series;Signal Transduction;small molecule;Spinal Cord;Symptoms;System;Testing;Therapeutic;Time;tool;tool development;Visualization;Zebrafish

PROJECT_TITLE: Investigating the role of cannabinoid receptors in oligodendrocyte development


ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: The proposed project is relevant to Veterans’ health by addressing two important conditions that affect Veterans: diabetes and viral infections. Existing research resources from the Million Veteran Program (MVP) will be used to identify relationships between genetic differences and risk of diabetes and infections. New information will be obtained from this existing genetic data that will help identify new factors related to diabetes and infections, including COVID-19. These data can then be used by other researchers in the future. This study will lead to new ways to understand risk for diabetes and infections in Veterans, and will inform future studies of new ways to prevent and treat these conditions.

PI_NAMEs: HULGAN, TODD M (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;Affect;Atlases;Bioenergetics;Clinical;Collaborations;Communicable Diseases;Complex;COVID-19;COVID-19 impact;Custom;Data;data resource;Data Set;defined contribution;Development;Diabetes Mellitus;diabetes risk;Disease;disorder risk;DNA;Dyslipidemias;experience;Future;gene environment interaction;Genes;Genetic;genetic association;genetic information;Genetic study;genetic variant;Genetic Variation;genome sequencing;Genotype;Health;High Density Lipoprotein Cholesterol;Hyperglycemia;Immune;immune activation;Immune response;Immunity;Infection;Inflammation;Innate Immune Response;innovation;interest;Interferon Type I;Interferons;Laboratories;Link;Measures;Metabolic;metabolic phenotype;Metabolism;Methods;Mitochondria;Mitochondrial DNA;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;Pathogenesis;Pathogenicity;phenome;Phenotype;precision medicine;prevent;programs;prototype;Regulation;Reporting;Research;Research Personnel;Resources;response;Risk;severe COVID-19;Signal Transduction;Subgroup;Variant;Veterans;Viral;Virus Diseases;whole genome;Work

PROJECT_TITLE: Defining the Contribution of Mitochondrial DNA to Viral Infectious Diseases, Type 2 Diabetes, and their Interactions


FUNDING_MECHANISM: OTHERS

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: This proposal is relevant to Veterans because it is the first study of a new treatment to help Veterans struggling with mild traumatic brain injury (mTBI), impulsivity and [suicidal ideation]. These three conditions have been shown to be linked [and all are associated with problems functioning]. First, this study will make sure the new treatment, intermittent theta burst stimulation (iTBS), which involves a high-powered magnet placed directly on the forehead, is safe and easy for Veterans to tolerate. Second, this project will also test to see if the treatment improves Veteran community functioning, [lessens suicidal ideation] and lessens impulsivity. Finally, Veterans enrolled in the study will get brain magnetic resonance imaging (MRI) before and after the treatment to determine how iTBS changes Veterans’ brain connectivity to make them function better. Completing this research will improve Veterans’ health through the development of a new treatment for impulsivity and suicidality following mTBI.

PI_NAMEs: AARONSON, ALEXANDRA LEIGH (contact)

PROJECT_TERMS: Address;Affect;Aftercare;Area;Behavior;Brain;Brain Injuries;brain magnetic resonance imaging;career;Caring;Cessation of life;Clinical;Clinical Trials;Communities;Data;Data Analyses;design;Development;Double-Blind Method;effective therapy;Elements;empowerment;Enrollment;Evidence based treatment;Exhibits;experience;Feeling suicidal;Forehead;Foundations;functional improvement;functional outcomes;Funding;Generations;Goals;Health;Image;improved;Impulsive Behavior;Impulsivity;Individual;innovation;K-Series Research Career Programs;Knowledge;knowledge base;Limbic System;Link;Magnetic Resonance Imaging;Mediating;Medical Records;Mental Depression;Mental Health;Mentors;Mentorship;mild traumatic brain injury;Mission;multidisciplinary;neural;neuroimaging;neurological rehabilitation;Neuronal Plasticity;neuropsychiatry;neuroregulation;novel;Occupational;Outcome;Pain;Participant;Persons;Physicians;Physiologic pulse;Pilot Projects;Play;Population;precision medicine;Prefrontal Cortex;prevent;Publishing;Randomized;rational design;Recording of previous events;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Project Grants;response;Rest;Risk;Risk Factors;Safety;safety and feasibility;safety testing;Sampling;Scientist;Self-Injurious Behavior;Serious Adverse Event;Side;skills;social;suicidal;Suicide;System;Testing;Therapeutic;therapy design;Training;Transcranial magnetic stimulation;treatment strategy;Veterans

PROJECT_TITLE: Neuromodulation for impulsivity and suicidality in Veterans with mildtraumatic brain injury and common co-occurring mental health conditions

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

PHR: Plant-based nitrates metabolize to bioactive nitrite and to putative capacity to enhance skeletal muscle mitochondrial respiration. We propose to study benefits of nitrate-rich beetroot juice to improve physical function in Veterans afflicted with long COVID. In a randomized, placebo- controlled trial, a two-week regimen of daily beetroot juice is used in combination with physical therapy. Trial endpoints include novel indices of fatigability and walking efficiency as well as peak oxygen utilization (VO2), VO2 at anaerobic threshold, 6-min walk distance, short physical performance battery, and pulmonary function. Skeletal muscle respiration is also assessed. Overall, this proposal is highly significant as it addresses a major Veteran healthcare challenge, and aligns with the Rehabilitation Research and Development’s mission to maximize Veterans’ functional independence, quality of life and participation in their lives and community.

PI_NAMEs: FORMAN, DANIEL E. (contact)

PROJECT_TERMS: acute COVID-19;Address;Adult;Aerobic;Amino Acids;Anaerobic Threshold;Arginine;Beverages;capsule;cardiorespiratory fitness;Chronic Obstructive Pulmonary Disease;Citrulline;Clinical;Communities;Consumption;COVID-19;COVID-19 impact;COVID-19 patient;Data;design;Diet;disability;Disease;efficacy study;Exercise;exercise regimen;Exertion;Fatigue;Foundations;functional decline;Functional disorder;functional independence;Health Care Costs;Healthcare;Healthcare Systems;Heart failure;hemodynamics;Hour;improved;indexing;Ingestion;innovation;Intervention;Investigational Drugs;Ischemia;Juice;Lead;Left;Long COVID;Measures;Mediating;Mission;Mitochondria;Muscle Mitochondria;Myalgia;Nitrates;Nitric Oxide;Nitrites;novel;older adult;Oxygen;Participant;patient population;Personal Satisfaction;Physical Function;Physical Performance;Physical therapy;Physiological;Placebos;Plants;post SARS-CoV-2 infection;Prevalence;primary endpoint;Principal Investigator;programs;pulmonary function;Pulmonary function tests;Quality of life;randomized placebo controlled trial;Randomized, Controlled Trials;Regimen;rehabilitation research;Rehabilitation therapy;Research;research and development;research study;Residual state;Respiration;Risk;SARS-CoV-2 infection;sedentary;Serology;Serum;Shortness of Breath;Signal Transduction;Signaling Molecule;Skeletal Muscle;Source;Standardization;Stress;Supplementation;Survivors;Symptoms;Therapeutic;Therapeutic Uses;United States Department of Veterans Affairs;Veterans;Walking;Work;young adult

PROJECT_TITLE: Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cystic Fibrosis;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Rare Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Enamel formation is a staged process principally involving secretory and maturation-stages, each associated with major changes in gene expression and cellular function, that results in an architecturally and mechanically complex hydroxyapatite-based bioceramic material devoid of most of the organic material that is essential in its making. Cellular activities that define the maturation-stage of amelogenesis include calcium, bicarbonate, chloride, proton and phosphate transport, and the strict control of intracellular and extracellular pH. This application seeks to fully understand the cellular activities that regulate and maintain an enamel extracellular matrix pH conducive to enamel mineralization.

PI_NAMEs: PAINE, MICHAEL LANSDELL (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Ameloblasts;Amelogenesis;Anions;Apical;apical membrane;Architecture;Bicarbonates;Binding;biomineralization;Calcium;Carrier Proteins;Cell Physiology;Cell Polarity;cell type;Cells;cellular microvillus;Chloride Ion;Chlorides;Clinic;Compensation;Complex;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Cytoskeleton;Data;Defect;Dental Enamel;Disease;Distal;Dysmorphology;Enamel Formation;Enamel Organ;Epithelial Cells;Event;extracellular;Extracellular Matrix;ezrin;F-Actin;Family member;Family suidae;Gene Expression;Gene Expression Regulation;Gene Family;Hydroxyapatites;In Vitro;in vivo;Inherited;inorganic phosphate;Inorganic Phosphate Transporter;Ion Channel;Ion Transport;Ions;Knockout Mice;Lateral;Link;Longevity;Maturation-Stage Ameloblast;Mechanics;member;Membrane;Messenger RNA;MicroRNAs;mineralization;Modeling;Morphology;Movement;Mus;mutant;Mutant Strains Mice;Nature;Pathology;Pathway interactions;prevent;Process;Proteins;Protons;Regulation;Reporting;Role;Site;Sodium;sodium-hydrogen exchanger regulatory factor;Time;Tissues;transcriptome

PROJECT_TITLE: Amelogenesis and Ion Transport

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Tuberous sclerosis complex (TSC) is a neurogenetic disorder with high rates of epilepsy and autism spectrum disorder due to dysregulation of the mechanistic target of rapamycin (mTOR) pathway. We have preliminary data suggesting that the transcription factor, EGR1, is down-regulated downstream of mTOR dysregulation in certain types of pyramidal neurons with loss of TSC2. We propose to characterize the mechanisms and consequences of this interaction in human neurons derived from induced pluripotent stem cells from patients with TSC, which will provide novel insight into the pathways underlying neurological symptoms in TSC. !

PI_NAMEs: WINDEN, KELLEN  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: activating transcription factor 3;Advisory Committees;Affect;Alleles;Animal Model;Applications Grants;Area;autism spectrum disorder;Bioinformatics;Boston;Brain;career;career development;Cell Differentiation process;Cell model;Child;Clinical Research;clinically relevant;Complex;Consensus;cortical tubers;Data;Development;Development Plans;Disease;Disinhibition;Dose;Down-Regulation;Electrophysiology (science);Engineering;Epilepsy;Excitatory Amino Acid Antagonists;extracellular;Foundations;FRAP1 gene;Functional disorder;Future;GABA Agonists;gamma-Aminobutyric Acid;Genes;Genetic Diseases;Genetic Models;Genotype;Glutamates;Goals;hippocampal pyramidal neuron;Human;Hyperactivity;Impairment;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Intellectual functioning disability;knock-down;Learning;Lentivirus;Measures;Mediating;Mentors;Modeling;Molecular;Molecular Biology;Monitor;multi-electrode arrays;Mutation;Nervous System Disorder;Neurocutaneous Syndromes;neurogenetics;Neurologic Symptoms;Neuronal Differentiation;Neurons;novel;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pediatric Hospitals;Phenotype;Phosphorylation;Phosphotransferases;Physicians;Physiology;Process;protein complex;Proteins;Proto-Oncogene Proteins c-akt;Repression;research and development;Research Personnel;Resistance;response;Role;Scientist;Signal Pathway;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Sirolimus;skills;Synapses;Syndrome;Techniques;Therapeutic Intervention;Time;Transactivation;transcription factor;Translational Research;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;Up-Regulation

PROJECT_TITLE: Molecular Mechanisms of Neuronal Hyperactivity in Tuberous Sclerosis Complex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Sex specific social interactions are a fundamental feature of the human experience and are crucial for individual and societal well-being. Moreover, several neuropsychiatric disorders such as Autism, Schizophrenia and Depression are characterized by sex differences in their prevalence, age of onset and severity. Understanding the molecular and neural circuit basis for the development and expression of behavioral sex- specificity is thus critical to understanding social behavior in normal and pathological contexts.

PI_NAMEs: BAMBAH-MUKKU, DHANANJAY  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Ablation;Age of Onset;Animals;antagonist;Architecture;autism spectrum disorder;Award;Behavior;Behavior Control;Behavioral;Brain;brain circuitry;Brain region;Cell Nucleus;cell type;Cells;Collaborations;critical period;Cues;Data;Development;Electrophysiology (science);Etiology;experience;experimental study;Female;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Transcription;Goals;Growth;Hormone Receptor;Hormones;Human;Hypothalamic structure;Impairment;In Situ;In Situ Hybridization;Individual;Knockout Mice;Laboratories;Libido;Link;male;Maps;Mediating;Mental Depression;Mental disorders;Methods;Modeling;Molecular;Mus;mutant;neural;neural circuit;neurodevelopment;neuromechanism;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;Neurosciences;novel;optogenetics;Output;patch clamp;Pathologic;Personal Satisfaction;Phase;Population;Positioning Attribute;Prevalence;Process;programs;Puberty;rabies viral tracing;Rabies virus;Research;response;Role;Schizophrenia;Sensory;Severities;sex;Sex Behavior;Sex Bias;Sex Differences;Sex Differentiation;sexual dimorphism;skills;Slice;social;Social Behavior;Social Interaction;Source;Specificity;Structure;Synapses;Synaptophysin;Tachykinin;Testing;tool;Training;Universities;Viral;virus genetics;Whole-Cell Recordings

PROJECT_TITLE: Development and function of a neural circuit underlying sex-specificity of social behaviors

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Relevance Statement. Insulin secretion is impaired in both major forms of diabetes, afflicting > 25 million Americans. This project investigates novel biochemical mechanisms of glucose-stimulated insulin secretion and potential therapeutic targets within those pathways.

PI_NAMEs: NEWGARD, CHRISTOPHER B (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: alpha ketoglutarate;American;Amino Acids;analog;B-Lymphocytes;Beta Cell;Biochemical;Biochemical Pathway;Biology;cancer cell;Cell membrane;Cell Physiology;Cells;Citrates;Citric Acid Cycle;Collaborations;Coupled;Diabetes Mellitus;Diazoxide;Disease;drug development;Endocrine;Engineering;exenatide;Exocytosis;experimental study;extracellular;global health;Glucagon;glucagon-like peptide 1;Glucose;glucose metabolism;Glutamine;glutaredoxin;Healthcare;hormonal signals;Human;human subject;Immune system;Impairment;Infusion procedures;Insulin;Insulin deficiency;insulin granule;insulin regulation;insulin secretion;interest;Investigation;islet;Islet Cell;Islets of Langerhans;Isocitrate Dehydrogenase;Isocitrates;Knock-out;Laboratories;Membrane;Membrane Potentials;Metabolic;Metabolic Pathway;Mitochondria;mitochondrial metabolism;Molecular;Mus;NADP;Non-Insulin-Dependent Diabetes Mellitus;novel;paracrine;Paracrine Communication;patch clamp;Pathway interactions;Patients;Peptide Hydrolases;Peptides;pharmacologic;Phase;Potassium Channel;preservation;Production;proglucagon;Proteins;public health relevance;Reaction;Reduced Glutathione;Regulation;Replacement Therapy;response;restoration;Rodent;Role;Secretory Vesicles;Signal Transduction;small molecule;Small Ubiquitin-Related Modifier Proteins;success;therapeutic target;type I and type II diabetes;voltage;Work

PROJECT_TITLE: Engineered Glucose Metabolism in Insulin Secreting Cells

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Sepsis

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Candida glabrata is the second major cause of candidemias owing in part to its ability to develop high level resistance to azole antifungal drugs. This application is focused on analyzing connections between the two major pathways for azole resistance.

PI_NAMEs: MOYE-ROWLEY, W SCOTT (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Alleles;anti-fungal agents;Aspergillus fumigatus;ATP-Binding Cassette Transporters;Attenuated;Automobile Driving;Azole resistance;Azoles;Biochemical;Biological Assay;C-terminal;Candida;Candida albicans;Candida glabrata;candidemia;Carrier Proteins;CDR1 gene;Cell membrane;Cell Nucleus;Cells;chromatin immunoprecipitation;Clinic;Collaborations;Complex;Coupled;crosslink;Data;DNA Binding;Drug Efflux;Drug resistance;efflux pump;Enzymes;Epitopes;Ergosterol;Exhibits;Fluconazole;gain of function;gain of function mutation;Gene Activation;Gene Expression;gene induction;Genes;genetic analysis;Genetic Transcription;Goals;Haploidy;High-Throughput Nucleotide Sequencing;Homologous Gene;Infection;insight;intermolecular interaction;Lanosterol;Lead;Link;Maps;Mass Spectrum Analysis;Mediating;Mediator;Molecular;mRNA Expression;multi drug transporter;Mutagenesis;mutant;Mutation;Organism;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Physiological;Polyenes;prevent;Production;Proteins;recruit;Regulation;Resistance;resistance allele;resistance mutation;response;Sepsis;Specificity;Sterols;Testing;transcription factor;Transcriptional Activation;Transcriptional Activation Domain;Transcriptional Regulation;transcriptome sequencing;Yeasts;Zinc Cluster

PROJECT_TITLE: Genetic analysis of pleiotropic drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Peripheral nerve diseases are very common and cause debilitating symptoms that include muscular weakness and atrophy, joint deformities, pain and sensory disturbances. We study the cells that form myelin in peripheral nerves, and showed that they need proteins called laminins, Rac1, Yap and Taz to myelinate. Here we seek to understand how these molecules work during myelination and if they are altered in human peripheral neuropathies, with the goal to promote re-myelination in patients.

PI_NAMEs: SIM, FRASER JAMES (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Axon;Binding;Biological Assay;Biopsy;Cadherins;cell behavior;Cell Communication;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cellular biology;Charcot-Marie-Tooth Disease;Complex;Data;debilitating symptom;Deformity;Demyelinating Diseases;Demyelinations;Development;disability;Disease;dosage;EGR2 gene;extracellular;Extracellular Matrix;Failure;Funding;Gene Dosage;Gene Expression;Genetic;Goals;Grant;Hereditary Motor and Sensory Neuropathy Type I;Hereditary neuropathy with liability to pressure palsies;Human;improved;in vivo;Joints;Laboratories;Laminin;Laminin Receptor;Libraries;Luciferases;Measures;mechanical signal;Mechanics;Mediating;Mediator;member;Modeling;Mus;Muscle Weakness;Muscular Atrophy;mutant;Myelin;myelination;Neuropathy;novel;overexpression;Pain;Pathway interactions;Patients;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenotype;PMP22 gene;Proteins;Rattus;remyelination;repaired;Research;rho GTP-Binding Proteins;Role;Schwann Cells;Sensory;Signal Pathway;Signal Transduction;small hairpin RNA;System;Testing;transcription factor;Work

PROJECT_TITLE: Laminin Receptors and Signals in Schwann Cells


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Advancements in neurotechnology are shaping the future of medical care for those suffering from neurological illness, disease, and injury. Unfortunately, it can take decades to bring such advances from the benchtop to the bedside in service of our Veterans. Translational success of implantable neurotechnology is constrained by the time, money, and personnel resources required to transition from benchtop demonstrations to preclinical and clinical evaluation of implanted medical devices. Development ecosystems are either highly flexible and necessitate significant redesigns before moving to final form; or highly specialized and prematurely limit the integration of new technologies. Here, we create an ideal solution that would provide maximal flexibility, simple integration of new components, and require minimal redesign for translation to preclinical and clinical studies. The central focus of this research program is to create a hardware and software platform that reduces the cost, time, and risk of device development, while maintaining component and design flexibility.

PI_NAMEs: BORTON, DAVID ALLENSON (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;Algorithm Design;Algorithms;American;Amplifiers;Architecture;bench to bedside;bioelectronics;Brain;Capital;Caring;Chronic;chronic pain;Clinical Research;Collaborations;Communication;Communities;Complex;Computer software;Computers;cost;Custom;Data;data acquisition;deep brain stimulator;density;design;Detection;Development;Device or Instrument Development;Devices;Disease;Drug Costs;Economic Burden;Ecosystem;Electrodes;Electronics;Electrophysiology (science);Evaluation;Feedback;first-in-human;flexibility;Future;Goals;Growth;Health Care Costs;Human Resources;human study;Implant;implantable device;improved;in vivo;Injury;innovation;instrument;Intellectual Property;Intervention;Investigation;Investments;Knowledge;Laws;Liquid substance;Logic;Longitudinal Studies;manufacture;Manufacturer;Marketing;Medical;Medical Device;medical implant;microchip;Mission;Nervous System;Nervous System Disorder;Nervous System Trauma;neural;Neurologic;Neurology;neuroregulation;Neurostimulation procedures of spinal cord tissue;neurotechnology;new technology;next generation;novel;novel therapeutics;Operating System;Parkinson Disease;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;pre-clinical;preclinical evaluation;preclinical study;premature;programs;Research;research and development;research clinical testing;Resources;restoration;Risk;Sensorimotor functions;Services;Shapes;Sheep;socioeconomics;Spinal;Spinal Cord;spinal cord and brain injury;Spinal cord injury;success;System;Technology;Telemetry;Testing;Textiles;Therapeutic;Thinness;Time;timeline;tool;Transistors;Translations;Tremor;United States Department of Veterans Affairs;United States Food and Drug Administration;Veterans;wireless;Writing

PROJECT_TITLE: Bridging bench to bedside with aneurotechnology cross-development platform

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Our goal is to improve music and speech perception for cochlear implant users. Presently, most cochlear implants discard the temporal fine structure of sound, which is information that is widely believed to contribute to both music and speech perception. The proposed work examines perceptual and physiological changes that occur once this information is provided to cochlear implant users in a clear and consistent manner.

PI_NAMEs: GOLDSWORTHY, RAYMOND L (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: Encoding Temporal Fine Structure for Cochlear Implants

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: Motor circuits such as corticospinal circuits are essential for skilled movement, and spinal interneurons mediate the information to motor neurons. In humans, interruption of motor circuits caused by spinal cord injury, stroke, or other disorders results in severe deficits in most fine motor skills. Therefore, understanding the cellular and molecular mechanisms underlying motor circuits including spinal interneurons will provide important information for developing new therapeutic avenues for addressing diseases and injuries related to motor or spinal circuits in humans.

PI_NAMEs: YOSHIDA, YUTAKA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 11 year old;Address;Affect;Anatomy;Axon;Behavior;Brain;Child;Complex;Cre driver;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Electromyography;Exhibits;expectation;Food;Forelimb;Goals;grasp;Human;Individual;Injury;Interneuron function;Interneurons;Interruption;Intervention;Knowledge;Lesion;Limb structure;Mammals;Maps;Mediating;Molecular;Motor;motor behavior;Motor Cortex;Motor disability;motor disorder;Motor Neurons;Motor Skills;Movement;Mus;Muscle;Neurons;novel;novel therapeutics;optogenetics;patch clamp;Pattern;Phase;presynaptic;Primates;Rabies virus;Research;Rodent;Role;sensory cortex;Shapes;Signal Transduction;skills;SLC17A8 gene;Spinal;Spinal Cord;Spinal cord injury;Spinal cord posterior horn;Stroke;Synapses;therapy design;Time;Virus

PROJECT_TITLE: Dissecting Spinal Interneuron Circuits to Control Skilled Movements

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Severe congenital heart defects like transposition of the great arteries are common birth defects requiring corrective newborn open heart surgery. With medical and surgical advancements, survival has improved for these children, though they continue to face significant neurodevelopmental challenges across the lifespan as a result of early abnormalities in the heart-brain connection. In this proposal we aim to understand the heart- brain connection beginning before birth and in the immediate newborn period in order to identify interventions that can optimize neurodevelopmental outcomes.

PI_NAMEs: PEYVANDI, SHABNAM  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adult;Affect;Aorta;Biological Markers;Birth;Brain;brain health;Brain Injuries;brain magnetic resonance imaging;Brain region;brain tissue;brain volume;Cardiac Surgery procedures;Cardiovascular Physiology;Cardiovascular system;cerebral hemodynamics;cerebral oxygenation;Cerebrovascular Circulation;Cerebrovascular Physiology;Cerebrum;CHD7 gene;Child;Closure by clamp;comparison control;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Coupled;d-transposition of the great arteries;Data;design;Development;Drops;Echocardiography;experience;fetal;Fetal Hemoglobin;Fetus;Future;Goals;Growth;Heart;Hematocrit procedure;Hour;improved;in utero;infancy;Intervention;Life;life span;Live Birth;Lung;Magnetic Resonance Imaging;Measures;Medical;Methods;motor impairment;Near-Infrared Spectroscopy;Neonatal;neonatal magnetic resonance imaging;neonate;Neurodevelopmental Impairment;neuroimaging;neuroprotection;Newborn Infant;Observational Study;operation;Operative Surgical Procedures;Outcome;Output;Oxygen;Participant;patient population;Patients;Perinatal;Physiological;Physiology;Placenta;Play;Population;Positioning Attribute;postnatal;Predisposition;Pregnancy;premature;prenatal;preterm newborn;primary outcome;programs;Pulmonary Vascular Resistance;rate of change;Research;restoration;Risk;risk mitigation;Role;Site;standard of care;Survivors;Testing;Third Pregnancy Trimester;Time;tissue oxygenation;Tissues;tool;Transposition of Great Vessels;ventilation;white matter injury

PROJECT_TITLE: The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD study

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The proposal seeks to understand mechanisms by which mutations in CACNA1 gene cause neurological disorders and to test the ability of novel, bioengineered molecules to correct the dysfunction.

PI_NAMEs: COLECRAFT, HENRY M. (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Behavioral Assay;Biological Assay;Biomedical Engineering;Biophysics;Cells;Classification;Clinical;clinically relevant;ClinVar;Closure by clamp;cohort;Collaborations;CRISPR/Cas technology;Data;Databases;de novo mutation;Development;Disease;effective therapy;efficacy evaluation;efficacy testing;Electrophysiology (science);Engineering;epileptic encephalopathies;Episodic ataxia;Etiology;falls;Familial Hemiplegic Migraine;Flow Cytometry;Functional disorder;functional group;gain of function;Generations;Genes;genome editing;GTP-Binding Proteins;Histology;human induced pluripotent stem cells;Image;Immunofluorescence Immunologic;in vivo;Individual;Induced Mutation;Induced pluripotent stem cell derived neurons;Inherited;innovation;Intellectual functioning disability;Ion Channel Gating;Ions;Karyotype determination procedure;Lentivirus Infections;loss of function;Microelectrodes;Modeling;Molecular;Morphology;mouse model;Mutation;nanobodies;Nervous System Disorder;neural network;neuron development;Neurons;neurotransmitter release;new therapeutic target;novel;novel therapeutics;P-Q type voltage-dependent calcium channel;Pathogenicity;Pathway Analysis;Patients;personalized approach;Physiological;Physiology;premature;presynaptic;Recombinants;Regulation;Resources;Scientist;screening;Slice;Terminator Codon;Testing;Therapeutic;tool;trafficking;Transfer RNA;Type 6 Spinocerebellar Ataxia;ubiquitin isopeptidase;Universities;variant of unknown significance;Vesicle;voltage

PROJECT_TITLE: Towards Novel Therapies for CACNA1A Neurological Disorders

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The ability to use sensory information to guide our actions is crucial for survival, yet we know remarkably little about the underlying brain mechanisms. This project aims to reveal a conceptual model for how sensory learning influences the activity of motor command circuits to guide behavior. These results will further our understanding of how learning influences the development of sensory-driven motor behaviors relevant in both health and disease.

PI_NAMEs: SIPPY, TANYA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Animals;Auditory;auditory discrimination;Basal Ganglia;Behavior;Behavior Control;Behavioral;Brain;Brain region;Calcium;cell type;Cells;Corpus striatum structure;Cues;Development;discrimination task;Disease;Dorsal;dorsal visual stream;experience;experimental study;Ganglia;Goals;Health;Image;in vivo;Learning;Link;Maps;Measures;Membrane Potentials;Methods;Modeling;Motor;Motor Activity;motor behavior;motor control;Motor output;Movement;Mus;neural;neuromechanism;Neurons;Output;Pathway interactions;Pattern;Play;Population;Population Dynamics;predictive modeling;Process;Property;Psychological reinforcement;recruit;response;Rewards;Role;Sensory;sensory input;sensory stimulus;Shapes;Site;Specific qualifier value;Synapses;Synaptic plasticity;Testing;Time;Training;Transgenic Organisms;Translating;two-photon;Whole-Cell Recordings;Work

PROJECT_TITLE: Sensory Plasticity in the Auditory Striatum as an Impetus for Action Control

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease;Patient Safety

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Of the 1.4 million annual visits to US emergency departments (EDs) for acute heart failure (AHF), nearly 90% lead to hospitalization, although many stable patients can be discharged from the ED and continue to recover at home. This proposal seeks to develop novel, patient-centered strategies to optimize hospitalization decisions for AHF, building upon extensive work to derive evidence-based clinical risk scores. My aims are to examine patient and clinician perspectives to better understand reasons for hospitalization, compare outcomes between low-risk patients who are hospitalized to those who are discharged from the ED, and pilot the implementation of a clinical decision support tool that encourages ED clinicians to perform comprehensive risk stratification for patients with AHF.

PI_NAMEs: KILARU, AUSTIN SRINIVAS (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;acute care;Address;Admission activity;Adoption;Adverse event;American;American Heart Association;Cardiology;Cardiovascular system;care delivery;career;career development;Caring;Characteristics;Clinical;Clinical Data;clinical decision support;clinical risk;college;cost;Data;Decision Making;Dedications;design;Development;Development Plans;Effectiveness;Electronic Health Record;Emergency Department patient;Emergency Department Physician;Emergency Medicine;Emergency Situation;Environment;Etiology;Evaluation;evidence base;experience;Funding;Goals;Guidelines;Health;Health Services;Health Services Accessibility;Heart failure;Home;Hospitalization;Hospitals;implementation evaluation;implementation science;implementation strategy;improved;improved outcome;Individual;innovation;Instruction;Interview;K-Series Research Career Programs;Lead;marginalized population;Medicine;Mentors;Mentorship;mortality risk;National Heart, Lung, and Blood Institute;novel;Outcome;Outcome Assessment;patient oriented;patient stratification;Patient-Focused Outcomes;Patients;Pennsylvania;Physicians;pragmatic intervention;Probability;Qualitative Methods;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;Resources;Retrospective cohort study;Risk;Risk Reduction;risk stratification;Self Care;Severities;skills;social;social health determinants;Structure;support tools;Techniques;Testing;tool;Training;Translations;treatment response;Universities;Visit;Work

PROJECT_TITLE: Implementing patient-centered strategies to optimize hospitalization decisions for emergency department patients with acute heart failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Social and economic stressors are increasingly recognized as important factors that shape the development of cardiovascular disease particularly among Latinos, who experience a disproportionate burden of these factors across the life course. However, the pathways through which social and economic stressors affect the biological pathways related to health disparities are not fully understood, particularly at the cellular level, and little research to date has examined how these factors impact cardiovascular markers early in the life course. We propose to address these gaps by examining how social and economic stressors experienced in childhood impact DNA methylation (e.g. DNA methylation age, genome-wide methylation) and mtDNA damage, among a diverse sample of Latino youth living in the US, as well as how these factors may impact their cardiometabolic health.

PI_NAMEs: ISASI, CARMEN R.;SUGLIA, SHAKIRA FRANCO (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Acceleration;Acculturation;Address;Adolescent;Adult;Affect;Age;Area;Behavioral;Biological;Biological Assay;Biological Process;Birth Place;Blood specimen;Buffers;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;caregiving;Child;Child Health;Childhood;Chronic;Chronic Disease;Chronic stress;cohort;Communities;Conflict (Psychology);Country;Data;Development;Diabetes Mellitus;Discrimination;DNA;DNA Damage;DNA Methylation;Economics;Environment;Epigenetic Process;epigenomics;ethnic identity;ethnic minority population;Ethnic Population;experience;Exposure to;Family;food insecurity;Genetic Transcription;genome wide methylation;Glucocorticoids;Health;health disparity;health disparity populations;High Prevalence;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hydrocortisone;Hypertension;Inflammation;Intervention;Latino;Latino Population;Life;Life Cycle Stages;Link;Lipids;Mendelian randomization;Mental Health;Methods;Methylation;Mitochondria;Mitochondrial DNA;Molecular;Nature;novel;Obesity;offspring;Outcome;Participant;Pathway interactions;Pattern;Physiological;Play;Policies;Poverty;Process;Race;racial population;Research;resilience;Resource Allocation;Risk;Role;Sampling;Shapes;Signal Transduction;Skin;social;Social Environment;social stress;social stressor;sociocultural determinant;Socioeconomic Status;socioeconomics;Stress;Stressful Event;stressor;Techniques;United States;Vulnerable Populations;Youth

PROJECT_TITLE: Social Stress, Epigenetics and Cardiometabolic Health Among Youth

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Neurosciences;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on characterizing poorly understood brain diseases caused by the immune system, known as autoimmune encephalopathies, through identification and validation of new antibodies as disease biomarkers. Once this work has been completed, these biomarkers have the potential to be informative in clinical practice for early diagnosis and immune treatment decisions, and disease mechanism research. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to reducing illness and disability.

PI_NAMEs: MCKEON, ANDREW  (contact)

PROJECT_TERMS: Acceleration;Address;Age;amphiphysin;Antibodies;Antigens;Ataxia;Autoimmune;Autoimmune Diseases of the Nervous System;Autoimmune encephalitis;Axon;Bacteriophages;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Brain Diseases;Cells;Cellular Assay;Cerebellar Ataxia;Characteristics;chemokine;Clinic;Clinical;clinical phenotype;clinical practice;Clinical/Radiologic;cohort;Complementary DNA;cytokine;Data;Degenerative Disorder;Diagnosis;disability;Disease;disease mechanisms study;Early Diagnosis;Early treatment;Encephalitis;Encephalopathies;Ethnic Origin;experience;Future;Goals;Health;Hippocampus;Human;IL8 gene;Immune;Immune system;Immunofluorescence Immunologic;Immunoglobulin G;Immunologics;Immunoprecipitation;Incidence;Indirect Fluorescent Antibody Technique;Indirect Immunofluorescence;Infectious Encephalitis;innovation;Investigation;Laboratories;Length;Libraries;Mass Spectrum Analysis;Methods;Mission;Molecular;Movement Disorders;Mus;neural;neuroimmunology;Neurologic;Neurological disability;Neurons;novel;novel marker;novel therapeutics;Nuclear;Ocular Motility Disorders;Outcome;Pathogenicity;Patients;Peptides;Phage ImmunoPrecipitation Sequencing;Phenotype;post-COVID-19;Prediction of Response to Therapy;Process;Protein Microchips;Proteins;Proteome;Public Health;Publishing;Radiology Specialty;Recombinant Proteins;Research;Research Personnel;screening;Serum;sex;specific biomarkers;Synapses;targeted treatment;Techniques;Testing;therapeutic development;Therapeutic Trials;Time;Tissues;Transfection;Translations;trial design;Undifferentiated;United States National Institutes of Health;Validation;Western Blotting;Work

PROJECT_TITLE: Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep Phenotyping

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Project Narrative: Novel deep learning frameworks for predicting nucleosome-binding proteins Nucleosome-binding proteins play an important role in development and organogenesis, but the experimental techniques used to identify them are insensitive, expensive or time consuming. This proposal aims to develop a novel two-stage transfer learning framework to predict these proteins by combining sequence and structural information. It will also implement a new transfer learning-continual learning framework that not only predicts the nucleosome binders in a species-specific manner, but also accommodates progressively available nucleosome- protein interaction data without forgetting previously learned knowledge.

PI_NAMEs: CUI, FENG  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Ablation;Amino Acid Sequence;Amino Acids;Area;base;Binding;Biomedical Research;Cell Differentiation process;Cells;Consumption;Data;Data Set;deep learning;design;Development;Dimensions;DNA;DNA Binding Domain;DNA-Binding Proteins;Embryonic Development;Evaluation;forgetting;Genome;Geometry;Grant;Graph;graph neural network;high dimensionality;HMGN Proteins;Homologous Protein;in silico;innovation;intermolecular interaction;Knowledge;Knowledge acquisition;knowledge base;Language;Learning;Learning Module;Literature;Measures;model building;Modeling;Modernization;Molecular Biology;Network-based;neural network;Neural Network Simulation;novel;Nucleosomes;Organogenesis;Performance;Plants;Play;predictive modeling;Process;protein aminoacid sequence;Protein Binding Domain;protein protein interaction;protein structure;Proteins;Publishing;Refractory;Research;RNA-Protein Interaction;Role;Rotation;self supervised learning;Speed;Structure;Techniques;three dimensional structure;Time;tool;Training;transcription factor;transfer learning;Translations;Update;Validation;vector

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_STATE: CA

PHR: Project Narrative We will develop and pilot test an online HIV stigma training in reducing stigmatizing attitudes and behaviors of nursing students in simulated clinical visits of patients live with or at-risk for HIV compared to an online HIV epidemiology training with no specific content on stigma. Our goal is to find an effective intervention to reduce stigma towards people at risk for HIV or living with HIV in Iran and other similar settings in the Middle East and other regions.

PI_NAMEs: MIRZAZADEH, ALI  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: adolescent health;AIDS prevention;antiretroviral therapy;arm;Attitude;Behavior;care systems;Caring;Case Study;Clinical;clinical encounter;Clinical Skills;clinical training;Code;Coupled;Data;Development;Diagnosis;Drug usage;Educational Intervention;effective intervention;effectiveness testing;Empathy;Epidemiology;experience;Feedback;field study;Frequencies;Friends;Future;Goals;Health care facility;Health Personnel;high risk;HIV;HIV diagnosis;Homophobia;Human immunodeficiency virus test;improved;Intervention;Interview;Iran;learned behavior;male;man;marginalization;Marriage;Maternal Health;Medical;men;Middle East;Needle Sharing;Nurses;Nursing Schools;Nursing Students;Participant;Patients;Persons;Pharmaceutical Preparations;Physician Assistants;Physicians;pilot test;Population;Populations at Risk;Random Allocation;Randomized;Randomized, Controlled Trials;Religious Belief;Reporting;Research;response;Risk;sex;Sexism;social culture;social stigma;Stigmatization;Students;testing services;tool;Training;Training Activity;Training Programs;Universities;Unsafe Sex;Video Recording;Visit;women patients

PROJECT_TITLE: Reducing stigmatizing attitudes and behaviors of nursing students in simulated clinical visits of patients living with HIV in Iran

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Relevance: Eukaryotic parasites such as N. fowleri, “the brain-eating amoeba”, are responsible for devastating central nervous system (CNS) infections. Lack of effective therapies results in nearly 100% fatality and novel clinical approaches are needed. There is evidence that the host immune response can slow or prevent fatal disease, and yet this fails in patients. We will determine how immune responses against extracellular parasites can be tuned for maximal efficacy within the CNS, while preserving neurological function. Using antibody isotype variants we will generate a clinically relevant understanding of how antibodies can be target CNS parasites for destruction and lay the groundwork for identifying potential immunotherapeutic options for treatment of CNS parasitic diseases.

PI_NAMEs: MOSEMAN, E. ASHLEY  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acanthamoeba;Amoeba genus;Animal Model;Antibodies;Antibody Response;Antibody Specificity;Antibody-Dependent Enhancement;Antibody-mediated protection;Antiparasitic Agents;Binding;Biological Assay;Brain;Cell surface;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cessation of life;Clinical;clinically relevant;Coculture Techniques;cohort;Complement;Data;Disease;Eating;effective therapy;Effector Cell;Engineering;Epitopes;Equilibrium;extracellular;Fostering;functional outcomes;Goals;Growth;Human;IgG1;Immune;immune activation;Immune response;Immunity;Immunoglobulin Class Switching;immunopathology;Immunotherapeutic agent;Immunotherapy;improved outcome;In Vitro;in vivo;Individual;Infection;Intervention;Intraventricular;intravital imaging;Invaded;Laboratories;Life Expectancy;Link;Mediating;Membrane Glycoproteins;Meningoencephalitis;Monoclonal Antibodies;Motility;mouse model;Mus;Naegleria;Naegleria fowleri;Nervous System Physiology;neuroprotection;neurotropic;neutralizing antibody;novel;novel therapeutic intervention;optimal treatments;Outcome;Parasites;Parasitic Diseases;Parasitic infection;passive antibodies;pathogen;Patients;Phenotype;Population;preservation;pressure;prevent;primary amebic meningoencephalitis;Proliferating;prophylactic;receptor;Recombinants;restraint;Specificity;Surface Antigens;Testing;Therapeutic;Therapeutic antibodies;Tissues;Treatment Efficacy;Vaccination;Variant

PROJECT_TITLE: Treatment of Primary Amoebic Meningoencephalitis via Modulation of Antibody Effector Functions

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Disability Research;Neurosciences;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Stroke is the leading cause of adult disability and no current treatments exist beyond physical therapy. This proposal explores the development of a biomaterial based therapy to promote recovery after stroke. The material promotes revascularization and synapse formation.

PI_NAMEs: SEGURA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adult;Area;Astrocytes;Axon;axon growth;Behavioral;Biocompatible Materials;Biomedical Engineering;Birth;Blood Vessels;Brain;Brain region;brain repair;brain tissue;Cells;Cerebral cortex;Clinical;clinical translation;Data;design;Development;disability;disability burden;Engineering;Environment;Experimental Designs;Formulation;Gel;Generations;Goals;Growth;Heparin;Human;Hyaluronic Acid;Hydrogels;Immune response;improved;in vivo;Infarction;Infiltration;inflammatory modulation;Inflammatory Response;Injectable;Injections;Integrin Binding;interest;Ischemic Stroke;Location;Mechanics;Medical;Monitor;Mus;nanoparticle;Natural regeneration;Necrosis;nerve stem cell;Neurologic;neurological rehabilitation;Neurons;new technology;novel therapeutics;particle;Physical Medicine;Physical therapy;Play;Population;Porosity;post stroke;programs;Proteins;Recovery;Repair Material;repaired;response;revascularization;RGD (sequence);Robotics;Role;scaffold;Signaling Molecule;Speed;stem cell biomarkers;stem cell differentiation;Stroke;Structure;Synapses;synaptogenesis;Technology;Therapeutic;Thrombospondin 1;Time;timeline;tissue repair;Tissues;Vascular Endothelial Growth Factors

PROJECT_TITLE: Biomaterials to promote synapse formation after stroke

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]