ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative The current proposal aims to determine the potential of mesenchymal stem cells from bone marrow, adipose tissue, and corneal limbus to differentiate in vitro into functionally active corneal endothelial cells, and the feasibility and efficacy of differentiated cell transplantation into the anterior chamber in vivo to restore corneal endothelial function. I propose a training plan that will allow me to achieve this goal through different biochemical and cellular techniques, and through in vitro, ex vivo, and in vivo models. If the in vivo phase demonstrates that differentiated cell transplantation is safe and effective, corroborating in vitro data, the treatment will be deemed worthy of further clinical investigation.

PI_NAMEs: ISLAM, MOHAMMAD MIRAZUL (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;adipose derived stem cell;Adipose tissue;Adult;Affect;Aging;Allogenic;Anabolism;Animals;anterior chamber;Aqueous Humor;Autologous;Award;beta catenin;Biochemical;biomaterial compatibility;Biomechanics;Blindness;bone marrow mesenchymal stem cell;Bulla;Bullous Keratopathy;career;Carpet;Cataract Extraction;CDKN2A gene;Cell Culture Techniques;Cell Cycle;Cell Density;Cell Differentiation process;cell injury;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Cellular biology;Cicatrix;Circulation;Clinical;clinical investigation;Clinical Trials;Coculture Techniques;Compensation;Complication;Cornea;Corneal Diseases;Corneal Endothelium;corneal epithelium;Corneal Stroma;Culture Media;Cyclin-Dependent Kinase Inhibitor;cyclin-dependent kinase inhibitor 1B;Data;Dehydration;density;design;Development;differentiation in vitro;Disease;disease model;Dislocations;Edema;Endothelial Cells;endothelial regeneration;Endothelium;Epithelial Cells;Epithelium;Evaluation;experimental study;Extracellular Matrix;Eye;Eye diseases;Failure;feasibility testing;first-in-human;Fuchs' Endothelial Dystrophy;Functional disorder;Functional Regeneration;functional restoration;Funding;Future;G1 Phase;gene therapy;Goals;Graft Rejection;Grant;Hereditary Disease;Homing;Human;Hydration status;Iatrogenesis;Immune;Immune response;improved;In Situ;In Vitro;in vivo;in vivo Model;Inflammatory Response;inhibitor;Injury;Keratoplasty;Lead;leadership development;limbal;Limbus Corneae;Liquid substance;Magnetic nanoparticles;Magnetic Resonance Imaging;Manuscripts;MAP Kinase Gene;materials science;mechanotransduction;member;Membrane;Mentors;Mesenchymal Differentiation;Mesenchymal Stem Cells;Modeling;Molecular;Molecular Biology;monolayer;multidisciplinary;Multipotent Stem Cells;nanoparticle;nerve stem cell;Neurons;Operative Surgical Procedures;Organ Culture Techniques;Oryctolagus cuniculus;Pathway interactions;Patients;Phase;Phenotype;PIK3CG gene;post-transplant;professor;Proliferating;Proteins;Pump;regeneration potential;Research;research faculty;Risk;Role;scaffold;Scientist;siRNA delivery;skills;Small Interfering RNA;Source;stem cell differentiation;stem cells;Stromal Cells;Structure of sinus venosus of sclera;Surface;Techniques;Testing;Therapeutic;three-dimensional modeling;Time;Tissue Engineering;Tissue Model;Training;Training Support;Transforming Growth Factor beta;Transplantation;tumor;Undifferentiated;United States National Institutes of Health;Visual impairment;Writing

PROJECT_TITLE: Mesenchymal Stem Cells can Restore and Maintain Corneal Endothelial Function


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Neurosciences;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: Gainesville

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MEDITRACE LLC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Neonatologists provide life-supporting care to babies born with difficult health conditions. In this proposal we will build an electronic tool to improve the quality of care and patient safety for these very fragile patients. Improved care is realized by providing a variety of clinical decision support tools to clinicians including: a continuous searchable stream of relevant data, smart thresholds and alarms, protocol support, shift-change hand-off support, and improved information visualization utilities that highlight critical changes in patient condition.

PI_NAMEs: CARNES, TONY CHRIS (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Adherence;Admission activity;Birth;Blood Pressure;Brain Injuries;care providers;Caring;Cerebrum;Clinical;clinical decision support;Clinical Practice Guideline;Clinical Research;Communication;Complex;Continuity of Patient Care;Data;Data Analyses;Data Collection;Data Display;data integration;Databases;design;Devices;effectiveness evaluation;Electronics;Environment;Equipment;Event;Evolution;experience;Feedback;Functional disorder;Future;Generations;Goals;Grant;Health;Health Status;Hospital Information Systems;Hypoxic-Ischemic Brain Injury;improved;improved outcome;Individual;information display;Intervention;Life Support Care;manufacture;Marketing;Measures;Medical Device;Modeling;Modification;Monitor;Morbidity - disease rate;multimodality;natural hypothermia;Neonatal;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonatal patient;neonate;neurodevelopment;neuroprotection;Newborn Infant;next generation;novel;Organ;Oxygen;Oxygen saturation measurement;Patient Care;Patient Monitoring;patient safety;Patients;Pattern;personalized approach;Phase;Physiological;Population;Predictive Value;prevent;Process;Protocols documentation;prototype;Publications;Quality of Care;remote monitoring;sensor;Severities;standard of care;Stream;success;support tools;Surveys;System;Techniques;Technology;Time;tool;Training;Treatment Effectiveness;trend;trend analysis;usability;Visualization;wireless

PROJECT_TITLE: Fast-Track Multimodal monitoring for neonatal neurocritical care


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE This study aims to evaluate child welfare policy and local factors to improve the wellbeing of pregnant people with substance use disorder and their infants. The study will include an evaluation of state-level Plan of Safe Care (POSC) policy, a quantitative assessment of how POSC has impacted infant outcomes and racial and ethnic disproportionality in infant foster placements, and a qualitative assessment of contextual barriers and facilitators of POSC implementation including which POSC elements may contribute to changes in racial and ethnic disproportionality.

PI_NAMEs: PATRICK, STEPHEN W (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: 1 year old;Accounting;addiction;Address;adverse outcome;Affect;age group;Alcohol consumption;Alcohols;Anthropology;Attention;battered child;Biometry;Birth;black women;care systems;Caregivers;Caring;Categories;Characteristics;Child;Child Abuse and Neglect;Child abuse prevention;Child Psychiatry;Child Welfare;Communities;Complex;Congresses;County;design;Diagnosis;Disparity;Drug usage;Effectiveness;Elements;Emergency department visit;Equity;Ethnic equity;Ethnic Origin;Evaluation;Family;federal policy;foster care;Fostering;Goals;Government;Harm Reduction;Health;health equity;illicit drug use;improved;improved outcome;Individual;Inequality;Infant;infant outcome;Injury;Intervention;Interview;Knowledge;Laws;Legal;Lived experience;maternal opioid use;Methodology;Mothers;multidisciplinary;Neonatal Abstinence Syndrome;Nonprofit Organizations;opioid epidemic;opioid use disorder;Outcome;Parents;Pediatrics;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical abuse;Policies;Policy Analysis;Policy Maker;postnatal;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Public Health;Publications;Race;racial disparity;Racial Equity;Regulation;Research;response;Services;Sexual abuse;Social Work;substance use;Substance Use Disorder;substance use treatment;Surveys;Syndrome;System;United States;White Women;Work

PROJECT_TITLE: Improving outcomes for substance-affected families in the child welfare system

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Nutrition;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Children with HIV-infection and those exposed to HIV without infection are at very high risk of becoming wasted (low weight-for-height or mid upper arm circumference). In the R21 phase of this grant, we propose to develop and test a novel mHealth intervention, called MAMMS-IYCF, that aims to facilitate the prevention and treatment of childhood wasting among these children. During the R33, we will then conduct a randomized clinical trial to establish the effectiveness of this novel intervention at improving child health outcomes.

PI_NAMEs: MEANS, ARIANNA RUBIN (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 2 year old;Acceleration;Address;adverse outcome;Age;Age Months;arm;Attitude;Behavioral;behavioral outcome;Breast Feeding;care seeking;care systems;caregiver education;Caregivers;Caring;Cessation of life;Child;Child Care;Child Health;Childhood;Clinic;clinical care;Complementary Feeding;Complex;Consumption;cost;Cost Analysis;cost effective intervention;cost effectiveness;design;Developmental Delay Disorders;Diagnosis;Diet;dietary;Early identification;Education;Effectiveness;effectiveness testing;empowerment;Enrollment;Exclusive Breastfeeding;Exposure to;Failure;Family;feeding;Feeds;follow-up;Food;Frequencies;Grant;Guidelines;health care availability;health care service;Health Personnel;Health system;Healthcare;Healthcare Systems;Height;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;Home;Hospitalization;implementation outcomes;improved;improved outcome;Incidence;incremental cost;Individual;Infant;Infection;Intention;Intervention;intervention delivery;Iron;Kenya;Knowledge;Life;Malnutrition;Measures;Medical;medical complication;Methods;mHealth;mhealth interventions;Monitor;Morbidity - disease rate;mortality;Mothers;novel;Nutritional;Nutritional Support;Opportunistic Infections;Outcome;Pathway interactions;Phase;phase III trial;Population;Predisposition;Prevalence;prevent;Prevention;Process;programs;Qualifying;Quasi-experiment;Randomized;randomized trial;randomized, clinical trials;Recommendation;Recovery;Reporting;response;Risk;Services;social stigma;standard of care;Surveys;System;Techniques;Testing;Text Messaging;Time;Trust;Underweight;Upper arm;vaccine response;wasting;Weight

PROJECT_TITLE: Developing a Two-way SMS Platform to Prevent and Treat Wasting Among HIV-infected and HIV-exposed Uninfected Children

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project narrative. Antibiotics are wonder drugs that have tamed bacterial infections over the past century. Unfortunately, pathogens are now becoming resistant to the best antibiotics used in clinical practice today. This project is aimed at identifying non-antibiotic strategies to prevent and treat bacterial infections. Successful execution of this project will add to the arsenal of tools we have to fight bacterial infections.

PI_NAMEs: BRITTON, ROBERT A (contact);LEMON, KATHERINE PAIGE;MARESSO, ANTHONY W;PATRAS, KATY

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Active Sites;Address;antagonist;Anti-Bacterial Agents;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriophages;beneficial microorganism;Benign;Biology;Cause of Death;Cessation of life;Chemical Structure;Chemicals;Chronic;Clinic;Clinical;clinical practice;Clinical Trials;Clostridium difficile;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Communities;Complex;COVID-19 pandemic;Development;Disease;Drug resistance;drug resistant pathogen;Ecology;Effectiveness;emerging pathogen;Environment;Enzymes;Equilibrium;ESKAPE pathogens;experience;Failure;fecal transplantation;fighting;Gastrointestinal tract structure;Genes;Genetic;Genitourinary system;gut colonization;Health;high risk;high risk population;Horizontal Gene Transfer;Human;Incentives;Individual;Infection;Infection prevention;innovation;Intestines;Learning;Life;Measures;methicillin resistant Staphylococcus aureus;Methods;microbial;microbial community;microbiome;microbiome therapeutics;microbiota;microbiota composition;Modeling;Modern Medicine;mucosal site;Mucous Membrane;Mutation;Nasal Epithelium;nasal microbiota;Nature;Nose;novel;novel therapeutics;Occupations;Organoids;Outcome;pandemic disease;pathobiont;pathogen;pathogenic bacteria;pathogenic Escherichia coli;Patients;Pharmaceutical Preparations;Planet Earth;pre-clinical;pressure;prevent;Prevention strategy;Process;programs;Property;prophylactic;Public Health;Recording of previous events;repository;Research;Resistance;Resistance development;resistant strain;Resistant Streptococcus pneumoniae;Scientist;Surface;synergism;Testing;Therapeutic;tool;transmission process;Transplantation;Uncertainty;urgent and serious threat;Vaccines;Validation;viral pandemic;Virus;Work

PROJECT_TITLE: Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention

PI_NAMEs: LEMON, KATHERINE PAIGE (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Affect;Air;Antibiotic Resistance;Apoptotic;attenuation;Bacteria;Bacterial Antibiotic Resistance;Bacteriophages;Benign;Biological Assay;Cell Culture Techniques;Cessation of life;Child;Clinical Trials;Coculture Techniques;Collection;colonization resistance;Colony-forming units;combat;Combating Antibiotic Resistant Bacteria;Communities;Corynebacterium;cytokine;Data;Epithelium;experience;fluorescein isothiocyanate dextran;Genome;Growth;Human;Immune response;improved;In Vitro;Infection;Infection prevention;innovation;Invaded;Knowledge;Liquid substance;Lytic;metabolomics;Methods;microbial;microbiome;microbiota;microbiota composition;Microscopy;Molecular;Mucous Membrane;Nasal Epithelium;nasal microbiome;nasal microbiota;nasal swab;Nose;Organoids;Outcome;pathobiont;Permeability;Persons;Physiology;Population;pre-clinical;Predisposition;prevent;Production;repaired;Reporting;Reproducibility;Resistance;response;Risk;Sampling;Serotyping;Shapes;Source;Staphylococcus aureus;Streptococcus pneumoniae;Surface;System;Testing;Therapeutic;Tight Junctions;tissue derived stem cell;Topical Antibiotic;transcriptomics;transmission process;Vaccines;Validation;Virulence

PROJECT_TITLE: Nasal Microbial Consortia Combat Antibiotic-Resistant Bacteria


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Although preterm birth is the leading cause of neurodevelopmental disorders, preterm infants are less likely than their term-age peers to receive human milk, which is recommended by the American Academy of Pediatrics to promote optimal neurodevelopmental outcomes. This novel research will explore how maternal postnatal stress may affect lactation/feeding outcomes for preterm infants in the K99 phase and use a biological systems approach in the R00 phase to elucidate how human milk and preterm infant gut composition may be altered by maternal stress in ways that impair neurodevelopment, with the goal of improving neurodevelopmental outcomes for this vulnerable population. The proposed work will assist in identification of targets for psychosocial intervention and supplementation of mother, milk, or infant to enhance the bioactive qualities of human milk and reduce the incidence of neurobehavioral disorders, thereby improving the health of preterm infants.

PI_NAMEs: NAGEL, EMILY M (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Academy;Affect;Age;American;Anxiety;auditory stimulus;Award;bacterial community;Biological;biological systems;Birth;Brain;Breast Feeding;career;career development;Caring;Characteristics;Choline;Clinical;cognitive function;Collection;Community Health;Computerized Medical Record;Data;Development;disability;Documentation;donor milk;Economic Burden;Electroencephalography;Electrophysiology (science);enhancing factor;Environment;Epidemiology;Event-Related Potentials;evidence base;experience;extreme prematurity;Fatty Acids;feeding;Future;Goals;Health;Hospitalization;Human Milk;human milk oligosaccharides;Hydrocortisone;Immune;Impairment;improved;Incidence;Infant;infant gut microbiome;Intervention;Lactation;Learning;Linear Regressions;Live Birth;maternal stress;Measurement;Measures;Medical;Mental Depression;Metabolic;metabolome;metabolomics;Metagenomics;microbial;microbiome;Milk;milk production;Minnesota;Modeling;Mothers;multiple omics;National Institute of Child Health and Human Development;Neonatal Intensive Care Units;neurobehavioral;neurobehavioral disorder;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;novel;nutrition;Nutritional;nutritional supplementation;Outcome;Pathway interactions;Pediatrics;peer;perceived stress;Phase;Physiology;postnatal;Pregnancy;Premature Birth;Premature Infant;Protocols documentation;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;Public Health Schools;Recommendation;Records;recruit;Research;resilience;response;Salivary;Science;Services;Severities;Signal Transduction;skills;sociodemographics;stool sample;Stress;Stressful Event;stressor;Supplementation;Techniques;Testing;therapy design;Time;tool;Training;Tryptophan;Tyrosine;Universities;Variant;Visual Cortex;Visual evoked cortical potential;Vulnerable Populations;Work

PROJECT_TITLE: Maternal Stress, Human Milk Composition, and Neurodevelopmental and Feeding Outcomes


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: HARTERT, TINA V (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acute;Age;age related;airway epithelium;Anti-viral Response;Asthma;asthma prevention;Biological;Biological Process;Birth;Candidate Disease Gene;Cell Differentiation process;Cellular Metabolic Process;Characteristics;Child;Childhood;Childhood Asthma;chronic respiratory disease;complex data;Data;Data Set;design;Development;Developmental Process;Disease;Disease Pathway;DNA Methylation;early childhood;Epithelial Cells;Epithelium;Etiology;experimental study;Funding;Genes;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genomic locus;Human;Hypersensitivity;Immune response;In Vitro;in vitro Model;Individual;individual variation;infancy;Infant;infant infection;Infection;Laboratories;Life;Lower Respiratory Tract Infection;Mediation;Mediator;Metabolic;Metabolism;metabolomics;Modeling;Morbidity - disease rate;mouse model;nasal microbiome;Nose;novel;Outcome;Pathway interactions;Phenotype;Play;Predisposition;Prevention;Process;programs;Publishing;Randomized;Recurrence;respiratory health;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Role;Series;sex;Sex Differences;Testing;Time;transcriptomics;Variant;Viral;Wheezing

PROJECT_TITLE: RSV and asthma: Defining host and exposure variation on disease development


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The multipotent neural crest cell population contributes to a wide range of derivatives including most of the craniofacial skeleton and dental tissue, and their aberrant development results in numerous human congenital defects including Mowat-Wilson Syndrome. These experiments will demonstrate precisely how ZEB2 regulates human neural crest cell formation, differentiation, and the Mowat-Wilson Syndrome pathology by coupling pluripotent stem cells with the development of a novel organoid model of human tooth formation. This project is relevant to the mission of NIDCR because the expected results will advance our understanding of the molecular underpinnings of this understudied pathology, and provide a unique platform from which to further explore molecular and environmental influences on human craniofacial and dental development.

PI_NAMEs: CHARNEY, REBEKAH  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;ATAC-seq;Binding;career;Cartilage;Cell model;Cephalic;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;Congenital Abnormality;Coupling;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;de novo mutation;Defect;Dental;Development;Diagnostic;Disease;embryo cell;Epigenetic Process;Epithelial Cells;epithelial to mesenchymal transition;experimental study;Face;Failure;Gene Expression;gene regulatory network;Genes;genetic corepressor;genome-wide;Genotype;Heterozygote;Human;human embryonic stem cell;human model;Human Pathology;improved;Individual;induced pluripotent stem cell;insight;Intellectual functioning disability;Investigation;Mediating;Methods;migration;Mission;Modeling;Molecular;Mowat-Wilson syndrome;multipotent cell;mutant;Mutation;National Institute of Dental and Craniofacial Research;Nervous System;Neural Crest;Neural Crest Cell;neural plate;novel;NuRD complex;Odontogenesis;oral cavity epithelium;Organ;Organoids;osteoblast differentiation;Osteoblasts;Pathology;Pathway interactions;Patients;Phase;Phenotype;Pilot Projects;Pluripotent Stem Cells;Population;Process;Protein Truncation;Protocols documentation;rare condition;receptor;recruit;Regulation;Repression;Role;Severities;Signal Transduction;Skeleton;Smad Proteins;Testing;Therapeutic;Time;Tissues;tool;Tooth Abnormalities;Tooth structure;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomics;Vertebrates;Work

PROJECT_TITLE: The role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PI_NAMEs: LEVY, PHILLIP DAVID (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TITLE: ACHIEVE GreatER: Addressing Cardiometabolic Health Inequities by Early PreVEntion in the Great LakEs Region


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: CHICAGO

ORG_NAME: ASIAN HEALTH COALITION OF ILLINOIS

ORG_STATE: IL

PI_NAMEs: RANDAL, FORNESSA T (contact)

PROGRAM_OFFICER_NAME: JAMES, SHEILA LENETTE

PROJECT_TERMS: All of Us Research Program

PROJECT_TITLE: AHC's National Strategy- All of Us Research Program


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The research proposed here will systematically quantify the effects of craniofacial transcription factor dosage changes on molecular, cellular, and morphological phenotypes. This work will provide: (1) mechanisms underlying sensitivity to transcription factor dosage in normal-range and disease-associated variation, (2) insights into the specific facial phenotypes observed in a range of craniofacial syndromes, and (3) basic insights into the mechanisms of transcription-factor mediated regulation. Finally, by driving forward our understanding of craniofacial variation and disease, the proposed research will nominate key genes and pathways that one day could inform disease prediction and/or therapeutic development.

PI_NAMEs: NAQVI, SAHIN  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Advisory Committees;Alleles;ATAC-seq;Automobile Driving;Binding;Biological;Biological Assay;brain shape;Buffers;career;career development;cell motility;Cephalic;Characteristics;Chemicals;Chromatin;Cleft Palate;Communities;Complex;Congenital Abnormality;craniofacial;craniofacial development;craniofacial disorder;Data;Data Set;deep learning;Defect;Development;Developmental Gene;Developmental Process;Disease;disorder risk;dosage;Dose;Educational workshop;embryo cell;Ensure;Environment;experience;Face;Faculty;Feedback;functional genomics;Gene Dosage;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;genome editing;genome wide association study;genome-wide;Goals;Grant;Human;human embryonic stem cell;Human Genetics;In Vitro;Individual;insight;Jaw;knock-down;Knock-out;Learning;Machine Learning;Mandible;Maps;Measurement;Mediating;Mentors;model building;Modeling;Molecular;Morphology;mouse genetics;MSX1 gene;Mutation;Nature;Neural Crest Cell;Normal Range;novel;Occupations;Pathway interactions;PAX3 gene;Phase;Phenotype;Pierre Robin Syndrome;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;predictive modeling;progenitor;programs;Proliferating;Proteins;Publications;Publishing;Rare Diseases;rare variant;Regulation;Regulator Genes;Regulatory Element;Reporter;Research;Resources;response;risk prediction;Role;Skeleton;skills;student mentoring;success;symposium;Syndrome;System;Systems Biology;Testing;TFAP2B gene;therapeutic candidate;therapeutic development;tool;Training;trait;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;TWIST1 gene;Untranslated RNA;Variant;Work;Writing

PROJECT_TITLE: Mapping and prediction of quantitative transcription factor dosage effects to understand variation in craniofacial morphology and disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The HCI Training Hub will contribute to the science of cancer health disparities (CHD) and promote the development of competitive, underrepresented cancer and CHD investigators. HCI and member program partners will increase dialogue, fuel collaborations, spur innovation, enhance diversity training, and positively impact cancer care in underserved communities.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: cancer care;cancer health disparity;Cancer Science;career;career development;career networking;Collaborations;Comprehensive Cancer Center;Development;Education and Outreach;Effectiveness;evidence base;Health Disparities Research;Health Promotion;Health Service Area;Huntsman Cancer Institute at the University of Utah;Idaho;innovation;Malignant Neoplasms;member;Monitor;Montana;Nevada;next generation;Productivity;programs;recruit;Research;Research Personnel;success;Training;underserved community;Utah;Wyoming

PROJECT_TITLE: Strengthening Research, Training and Outreach Capacity in Huntsman Cancer Institute's Mountain West Service Area


ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative: Coronaviruses can emerge from wildlife reservoirs and infect humans resulting in outbreaks of pneumonia, as we are experiencing with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We want to identify how coronaviruses evade the early warning system of the immune response. These studies will teach us how coronaviruses slip under the radar of our immune defenses and cause disease.

PI_NAMEs: BAKER, SUSAN C. (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Address;Animals;antagonist;Antibodies;antiviral drug development;betacoronavirus;Cells;Chicago;Circulation;Complex;Coronavirus;Coronavirus Infections;Cryoelectron Microscopy;Disease;Disease Outbreaks;Doctor of Philosophy;Double-Stranded RNA;Educational process of instructing;Endoribonucleases;Enterocytes;Excision;experience;Family;Generations;Goals;Human;Immune;Immune response;Individual;Innate Immune Response;Interferometry;Interferon Activation;interferon antagonist;Interferons;Kinetics;Knowledge;Macrophage;Measures;medical schools;Membrane;Mus;mutant;Mutation;novel coronavirus;pandemic disease;Pathogenesis;Pathogenicity;Pattern recognition receptor;Pneumonia;preference;Process;Proteins;replicase;Reporting;response;reverse genetics;RNA;RNA Viruses;Role;SARS-CoV-2 infection;Structure;Universities;Uridine;Vaccines;Viral;Viral Proteins;viral RNA;Virulence Factors;Virus;Virus Replication

PROJECT_TITLE: Investigating Interferon Antagonists in Delaying Innate Immune Responses to SARS-CoV-2


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: NARRATIVE Pharmaceutical drugs have reduced mortality and morbidity across all areas of medicine; however, key challenges such as undesirable side effects, poor efficacy, and the need for frequent administration or complex administration routes limit their ability to have even more pronounced impact on patient welfare. The projects described within this proposal seek to overcome these challenges by developing injectable drug delivery platforms that can precisely control pharmacokinetics, reduce the frequency at which drug needs to be readministered, deliver biologics in their bioactive form, and enable multi-drug therapies that match dynamic patient needs. To achieve these goals, we will develop surface-eroding biomaterials that protect the encapsulated payload in combination with advanced fabrication methods that define microparticle geometry— and thus the release of drugs encapsulated in surface-eroding materials—to rationally design injectable particles that are compatible with a broad array of drug classes and exhibit predictable release kinetics.

PI_NAMEs: MCHUGH, KEVIN JAMES (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3D Print;absorption;Acute;Area;Behavior;Biocompatible Materials;Biological;Biological Products;Chemistry;Chronic;Chronic Disease;Clinical;Complex;controlled release;Disease;Dose;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Dryness;Encapsulated;Exclusion;Excretory function;Exhibits;fabrication;FDA approved;Formulation;Frequencies;Geometry;Goals;Half-Life;Health Care Costs;Hydrophobicity;improved;Injectable;interest;Kinetics;manufacture;Medicine;Methods;model design;Morbidity - disease rate;mortality;multi-photon;nanofabrication;next generation;particle;Patient Compliance;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Pharmacy (field);Polymers;prevent;rational design;Regimen;Route;Running;Safety;side effect;Site;Structure;Structure-Activity Relationship;Surface;System;Therapeutic;therapy duration;Water;welfare

PROJECT_TITLE: Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PI_NAMEs: GORAN, MICHAEL ISAAC (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Diabetes prevention intervention for Latinos  combining smartphone continuous glucose monitoring and narrative video clips


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Massey Cancer Center (MCC) is to reduce the state cancer burden for all Virginians by addressing the confluence between biological, social, and policy drivers through high-impact, cutting-edge research; person-centered care across the continuum, from prevention through survivorship; community integration; and training the next generation of community-centric researchers and healthcare professionals. The core of this mission has been supported by the National Cancer Institute’s Cancer Center Support Grant (CCSG) since 1975, and the MCC is seeking renewal of this award for another five years. The CCSG supports efforts across the MCC senior and programmatic leadership; administration; community outreach and engagement; cancer research training and education coordination; promotion of center-wide diversity, equity, and inclusion; shared resource support and management; clinical research infrastructure; and developmental funding to supporting team-based, transdisciplinary research strategies focused on well-defined, catchment area priorities.

PI_NAMEs: WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Academia;Academic Medical Centers;Address;African American;Algorithms;anti-cancer research;Appointment;Area;authority;Award;Basic Science;Behavioral;Biological;Biometry;Black race;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Cancer Survivorship;cancer therapy;career development;Caring;Catchment Area;Charge;Cities;Clinical;clinical implementation;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;college;Communities;Community Clinical Oncology Program;community engagement;Community Integration;Community Outreach;County;Crime;data acquisition;Data Analyses;Death Rate;Development;Developmental Therapeutics Program;Disparity;driving behavior;Education;Education and Outreach;electronic medical record system;Ensure;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Excess Mortality;Faculty;Flow Cytometry;Fostering;Funding;Geography;Goals;Growth;Health;health disparity;Health equity research;Health Policy;Health Professional;Health Promotion;Health system;Home;Hot Spot;Housing;improved;Incidence;Individual;innovation;Institution;Intervention;Intervention Trial;Investments;Knockout Mice;Leadership;lipidomics;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;medically underserved;member;Mentors;metabolomics;Methodology;Microscopy;Mid-Atlantic Region;Minority;Mission;Modeling;multidisciplinary;National Cancer Institute;neighborhood disadvantage;next generation;Obesity;Outcome;Patient Care;Peer Review;person centered;Policies;Population Sciences;Positioning Attribute;Poverty;Prevention;Prevention approach;Primary Care;Production;Productivity;programs;Publications;Race;racial minority;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Rural;rural area;Schools;Science;Scientist;Screening for cancer;Services;Smoking;smoking-related cancer;social;social health determinants;socioeconomic diversity;socioeconomics;Specialist;Speed;Strategic Planning;Students;success;survivorship;Technology;Tissues;Tobacco;Training;Training and Education;Transgenic Organisms;Translations;Underrepresented Minority;underserved area;United States Health Resources and Services Administration;Universities;Virginia;Vision

PROJECT_TITLE: TRAINING NAVIGATOR CCSG SUPPLEMENT

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE This project seeks to develop small-molecule antagonists of the K-RAS oncogene to inhibit tumor growth in cancer. The project is relevant to public health because small molecules that emerge from this work may lead to therapeutic agents for treatment of patients with pancreatic, lung, and colon cancer. The project is relevant to the NIH’s mission as it has the potential to reduce mortality due to range of cancers driven by aberrant K-RAS signaling.

PI_NAMEs: MEROUEH, SAMY  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: adduct;Affinity;Amino Acids;antagonist;Binding;Binding Sites;Biochemical;Biological;Biological Assay;cancer cell;Cancer cell line;Cell Proliferation;Cell Survival;Cells;Cellular biology;cheminformatics;Clinical Trials;Codon Nucleotides;Collection;Colon Carcinoma;Colorectal;Colorectal Cancer;Communities;Computing Methodologies;covalent bond;Cysteine;Data;design;Development;Event;experience;Fluorescence;Fluorides;Goals;GTP Binding;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;inhibitor;KRAS2 gene;lead optimization;Libraries;Ligands;liquid chromatography mass spectrometry;Lung Adenocarcinoma;Lysine;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Methods;Mission;mortality;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;Nucleotides;Oncogenes;Oncogenic;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pharmaceutical Preparations;Phosphorylation;Positioning Attribute;Proliferating;Proteins;Public Health;RAS driven tumor;Ras Inhibitor;Reaction;reaction rate;Reporting;Resolution;Roentgen Rays;screening;Serine;Signal Transduction;Site;small molecule;small molecule inhibitor;Solubility;Son;structural biology;Structure;Testing;Therapeutic;Therapeutic Agents;therapeutic development;three dimensional structure;Threonine;Time;tumor;tumor growth;Tyrosine;United States National Institutes of Health;Western Blotting;Work;X-Ray Crystallography

PROJECT_TITLE: A Fragment-Based Strategy for K-RAS Covalent Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Infectious Diseases;Patient Safety;Sepsis

ORG_CITY: HERSHEY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Sepsis is a global epidemic with a high disease burden, although clinicians caring for septic patients are unable to distinguish between septic patients who will rapidly recover and those who will develop a prolonged disease course marked by significant morbidity and mortality. This is partly due to our incomplete understanding of the complex underlying immune responses in sepsis as well as our inability to translate research findings into information that is useful to clinicians. This research will contribute to the development of novel techniques that will help clinicians to get individualized results about their patients’ immune responses, to guide their decisions about whether immune-adjuvant therapy may be appropriate for each patient.

PI_NAMEs: BONAVIA, ANTHONY S (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Academic Medical Centers;Acute;Adjuvant Therapy;Affect;Biological Assay;burden of illness;cancer therapy;Caring;Cell Separation;Cells;Cessation of life;Chronic;chronic infection;Clinical;clinical care;clinical predictors;Clinical Research;clinical risk;Complex;Critical Illness;cytokine;Data;Development;Disease;Epidemic;Functional disorder;Goals;Health Care Costs;Human;human model;Iatrogenesis;Immune;Immune response;Immune System Diseases;Immune Tolerance;Immunologic Adjuvants;Immunologics;in vitro Model;Inflammation;Measurement;Medical;metabolomics;Microfluidics;Morbidity - disease rate;mortality;Myeloid Cells;Myeloid-derived suppressor cells;National Institute of General Medical Sciences;novel;Operative Surgical Procedures;participant enrollment;Patients;Peripheral Blood Mononuclear Cell;Phenotype;point of care testing;Pre-Clinical Model;Preclinical Testing;prognostic;prognostic value;prospective;recruit;Research;Research Priority;response;secondary infection;Secondary to;Sepsis;septic patients;Syndrome;Techniques;tertiary care;Testing;theories;Tissues;tool;transcriptomics;Translating;trial enrollment;Whole Blood

PROJECT_TITLE: Integration of Immunologic Phenotyping with Computational Approaches to Predict Clinical Trajectory in Septic Patients


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Vaccine Related

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Residents of correctional facilities are disproportionately at risk of developing and dying of COVID-19. To mitigate the spread of SARS-CoV-2, Departments of Correction have instituted prevention measures including vaccine campaigns, social distancing, and mass screening. Through this proposal, we seek to derive an evidence base for these prevention measures and develop an adaptive intervention simulation model to identify scenarios when prevention measure modification is justified.

PI_NAMEs: LIND, MARGARET  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Active Learning;adaptive intervention;Advisory Committees;Affect;Award;burden of illness;Calibration;career;combat;Communicable Diseases;Communities;community burden;community-level factor;Complex;Connecticut;Contracts;Coupled;COVID-19;COVID-19 burden;COVID-19 mortality;COVID-19 prevention;COVID-19 risk;COVID-19 test;COVID-19 vaccination;Data;Development;discrete time;Disease;disease transmission;disorder control;Effectiveness;effectiveness evaluation;effectiveness testing;Epidemiologist;Epidemiology;Evaluation;evidence base;experience;feasibility testing;flexibility;Funding;Future;Goals;Government;Growth;hazard;Hazard Models;health disparity;Herd Immunity;high risk;Hospitalization;Household;improved;Individual;Infection;Infection Control;infection risk;Intervention;Jail;Knowledge;Left;marginalized population;Mass Screening;Measurable;Measures;Mentors;Methodology;Methods;microbial disease;model development;Modeling;models and simulation;Modification;Nature;novel;Output;Persons;Phase;Policies;Policy Maker;Population;Predisposition;prevent outbreaks;prevention effectiveness;Prevention Measures;Prevention strategy;Prisons;programs;Protocols documentation;Public Health Schools;Research;Respiratory Tract Infections;Risk;Risk Reduction;Role;SARS-CoV-2 infection;SARS-CoV-2 transmission;Scientist;simulation;skills;Social Distance;Social Network;Structure;symptomatic COVID-19;Testing;Time;Training;Training Programs;transmission process;treatment effect;United States;unvaccinated;Vaccinated;Vaccination;Vaccinee;Vaccines;Validation;Variant;Viral;Vulnerable Populations

PROJECT_TITLE: Identifying and evaluating prevention strategies for COVID-19 in correctional facilities

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH We have developed a minimally invasive approach to determine the expression of DNA damage response (DDR) biomarkers in human PBMCs (from whole blood sample). In this proposal, we will analytically validate the Luminex multiplexed assay which uses the multi-analyte platform (xMAP) technology (UH2 phase) and then establish clinical validity by using biospecimens from the Fox Chase Cancer Center Biosample Repository Facility and from two clinical studies in locally advanced rectal cancer (UH3 phase). The ultimate goal of this research is to utilize the blood-based DDR biomarkers to guide patient stratification for treatment in the setting of locally advanced rectal cancer and potentially other cancers in the future.

PI_NAMEs: ARORA, SANJEEVANI  (contact);MEYER, JOSHUA E.

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Academic Medical Centers;Adjuvant;assay development;Basic Science;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker validation;Blinded;Blood;Blood specimen;Calibration;Cancer Center;cancer clinical trial;Cancer Patient;candidate marker;candidate validation;cell immortalization;Cell Line;Cells;Characteristics;CHEK1 gene;CHEK2 gene;chemoradiation;Chemotherapy-Oncologic Procedure;Clinical;clinical development;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;clinically actionable;Collaborations;cross reactivity;Cryopreservation;detection limit;Disease-Free Survival;DNA Damage;Evaluation;Exhibits;experience;Fox Chase Cancer Center;Funding;Future;Gamma-H2AX;Goals;Healthcare Systems;Human;Immunoassay;Immunofluorescence Immunologic;improved;In complete remission;Laboratories;lead candidate;Malignant Neoplasms;MDM2 gene;minimally invasive;Modality;monocyte;multidisciplinary;multiplex assay;Neoadjuvant Study;Neoadjuvant Therapy;Newly Diagnosed;novel therapeutic intervention;Operative Surgical Procedures;Pathologic;Pathology;Patient Care;patient population;patient stratification;Patients;Performance;peripheral blood;Phase;Phosphorylation;predicting response;predictive marker;Primary Neoplasm;Proteins;Public Health;quantitative imaging;Radiation therapy;Reagent;Rectal Cancer;Rectum;Reproducibility;Research;Research Design;Research Personnel;response;response biomarker;Sampling;segregation;Sensitivity and Specificity;Signal Transduction;Specimen;standard of care;Standardization;Surrogate Endpoint;Technology;Testing;TP53 gene;translational study;treatment response;treatment stratification;Validation;Variant;Whole Blood;Work

PROJECT_TITLE: Validation of blood-based predictive biomarkers of therapeutic response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative The efforts outlined will collect and analyze 9,500 PBMCs and 10,000 PAXgene RNA samples, which will allow for novel studies of genetic and immune factors contributing to disease. This data will enrich our database, inform precision medicine approaches, and improve health outcomes for these underrepresented groups.

PI_NAMEs: ANDERSON, GARNET L. (contact);CHAN, KWUN CHUEN GARY ;FLOYD, JAMES S;KAPLAN, ROBERT C

PROGRAM_OFFICER_NAME: SANTOS, STEPHANIE

PROJECT_TERMS: Adaptive Immune System;Address;Adipocytes;Administrative Supplement;Asian Americans;B-Lymphocytes;biobank;bioinformatics tool;Biologic Characteristic;Biological Assay;Biological Markers;Biomedical Research;Biotechnology;Blood;Blood specimen;blood-based biomarker;Cardiac Myocytes;cardiometabolism;CD3 Antigens;Cell Physiology;cell repository;cell type;Cells;Chronic Disease;Clinical;Clinical Data;cohort;Collection;Communities;cost;Data;Data Compromising;data integration;data quality;Databases;Development;Disease;Disparity;Ensure;Estimation Techniques;Face;field study;Flow Cytometry;Future;Gene Expression;Gene Expression Profile;Genetic study;genomic data;Genomics;Health;health disparity;Hepatocyte;Immune;immune function;Immune response;Immune system;Immunologic Factors;improved;Individual;induced pluripotent stem cell;Innate Immune System;insight;Intervention;Investigation;Longitudinal cohort study;Measurement;Measures;Mental Health;Meta-Analysis;Methods;Molecular;monocyte;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;Native Hawaiian or Other Pacific Islander;novel;Observational Study;Organ;Outcome;Pacific Islander;Participant;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Population;Population Characteristics;precision medicine;Predisposition;preservation;Process;programs;Protocols documentation;repository;Research;response;RNA;Role;Sampling;Services;Signal Transduction;single cell sequencing;Source;Specimen;Standardization;Stimulus;T-Lymphocyte;therapeutic target;Trans-Omics for Precision Medicine;transcriptomics;Tube;Underrepresented Populations;Whole Blood

PROJECT_TITLE: Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) Administrative Supplement for PBMCs and RNA PaxGene


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This grant application will evaluate a novel role of the antioxidant protein peroxiredoxin 6 in the regulation of cellular respiration and a new non-apoptotic cell death pathway. The results of this effort will increase our understanding of basic biochemical pathways that underlie cellular homeostasis and are dysregulated in several pathophysiological conditions.

PI_NAMEs: VAZQUEZ MEDINA, JOSE P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute Lung Injury;Acylation;Acyltransferase;Affect;analytical tool;Antioxidants;Applications Grants;Biochemical Pathway;Biological Assay;Biology;carcinogenesis;Catalytic Domain;Cell Death;cell growth regulation;Cell membrane;Cell Respiration;Cells;Central Nervous System Diseases;Chronic;Cystine;Data;Degenerative Disorder;Disease;Enzymes;Equilibrium;extracellular;Future;Gene Expression Profile;glutathione peroxidase;Homeostasis;Hydrogen Peroxide;Hypoxia;Imaging Techniques;Inflammation;interest;Iron;Ischemia;Lysophosphatidylcholines;Maintenance;Male Infertility;Mediator;Mitochondria;mitochondrial metabolism;Morphology;Mus;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidation-Reduction;oxygen toxicity;Pathway interactions;peroxiredoxin;Phospholipase A2;Phospholipids;Physiological;Point Mutation;Prevention strategy;Proteins;Regulation;repair enzyme;Reperfusion Injury;Respiration;Retinal Diseases;Role;Stroke;Three-Dimensional Imaging;translational approach;Traumatic Brain Injury;uptake

PROJECT_TITLE: The Biology of Peroxiredoxin 6

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: HS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: The overarching goal of our proposal is to revolutionize mental health intervention by providing a model for evidence-based digital health intervention (DHI) to enhance and sustain mental health treatment for children with Attention Deficit Hyperactivity Disorder (ADHD). Our DHI uses Patient-Centered Digital Healthcare Technologies to promote co-regulation (child/parent), capture patient data, support efficient healthcare delivery, enhance patient engagement, and facilitate shared decision-making, thereby improving access to timely and targeted mental health intervention for children at risk for poor outcomes.

PI_NAMEs: LAKES, KIMBERLEY DAWN (contact)

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: Digital Health Intervention for Children with ADHD: Improving Mental Health Intervention, Patient Experiences, and Outcomes

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: RELEVANCE Pharmacy-based models of care can close a critical implementation gap in delivering HIV testing and PrEP to priority populations affected by the HIV epidemic. Utilizing well-established implementation science frameworks, this study will examine key determinants, strategies, and mechanisms of implementing rapid HIV testing and PrEP initiation in community pharmacy settings, with the goal of maximizing the program’s acceptability, feasibility, appropriateness, and reach. The research will provide key implementation data for an adaptable pharmacy-based HIV testing and PrEP initiation model that can reduce health inequities and expand access to these evidence-based practices in communities affected by HIV.

PI_NAMEs: COLLMAN, RONALD G (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;AIDS prevention;Area;Black Populations;Caring;Chronic Disease;Cities;Clinic;clinical trial implementation;college;Communities;Community Pharmacy;community setting;condoms;Consolidated Framework for Implementation Research;Counseling;County;Data;Development;Diagnosis;Diagnostic Reagent Kits;Drops;Educational Curriculum;effectiveness clinical trial;effectiveness/implementation hybrid;efficacy testing;Eligibility Determination;Epidemic;Equity;ethnic disparity;Evaluation;Event;evidence base;Evidence based practice;experience;Focus Groups;Funding;Future;Goals;Health;health care delivery;health equity;health inequalities;Health Services;HIV;HIV Infections;Human immunodeficiency virus test;implementation barriers;implementation determinants;implementation evaluation;implementation facilitators;implementation framework;implementation intervention;implementation outcomes;Implementation readiness;implementation strategy;Individual;Injectable;insight;Intervention;Interview;Latinx population;Laws;medical specialties;Methods;Modeling;Neighborhoods;Online Systems;Oral;Outcome;Patient Compliance;Pennsylvania;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Phase;Philadelphia;Population;Population Heterogeneity;Positioning Attribute;Practice Guidelines;pre-exposure prophylaxis;prevent;Process;Proctor framework;Program Acceptability;programs;Public Health;racial disparity;Recommendation;Reduce health disparities;Research;Risk Factors;Saints;Science;screening;self testing;service delivery;Services;Site;success;Surveys;tool;Treatment Efficacy;Trust;Universities;uptake;urban area;Work

PROJECT_TITLE: Penn - Center for AIDS Research


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative  This supplement project extension is designed to strengthen research, training, and outreach by the Fred & Pamela Buffett Cancer Center with the goal of training predoctoral, postdoctoral, and early-stage faculty scholars from American Indian, Hispanic, rural, and financially disadvantaged populations, which are often overlapping populations within Nebraska. This project extension will focus on guiding diverse scholars into the pathway of cancer-related research training, optimizing their professional development and networking skills, and facilitating the advancement of these scholars through NCI workforce opportunities. In addition, during this project extension we will prepare to monitor the scholars’ success as they advance in their careers in cancer research and clinical care, and we will conduct evaluations of the training activities’ outcomes, complete project reports, and disseminate the knowledge gained from this project on best practices in mentoring these scholars.

PI_NAMEs: SWEASY, JOANN B. (contact)

PROJECT_TERMS: Address;Administrative Supplement;Agreement;American Indians;anti-cancer research;Back;Cancer Burden;cancer care;Cancer Center;cancer education;cancer health disparity;career;Career Choice;Career Exploration;Catchment Area;Categories;Clinical Cancer Center;clinical care;Communities;demographics;design;Development;disadvantaged background;disadvantaged student;Disparity;Disparity population;Education;education research;Educational workshop;ethnic minority;Evaluation;Faculty;Fees;Funding;Goals;Grant;Health;Healthcare;high school;Hispanic;innovation;Institution;interest;junior high school;Knowledge;Laboratories;Learning;Malignant Neoplasms;Medical center;Medicine;member;Mentors;Mission;Monitor;National Cancer Institute;Nebraska;Outcome;outreach;Pathway interactions;patient oriented;Policies;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Privacy;Procedures;programs;Publications;racial minority;Readiness;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Rural;Scholarship;Science;Services;Site;skills;success;symposium;Targeted Research;Training;Training Activity;Training and Education;translational cancer research;underrepresented minority student;United States National Institutes of Health;Universities;university student;Work;Writing

PROJECT_TITLE: Buffett Cancer Center Supplement to Strengthen Research, Training, and Outreach


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: RUDGE, THOMAS  (contact)

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;product development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task V01: Administrative Support for Evaluation and Testing Services (ETS) for Vaccines and other Biologics for Infectious Diseases


ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

PI_NAMEs: PENNY, BRIAN  (contact)

PROJECT_TERMS: analytical method;Chemistry;Clinical Trials;Contractor;Cyclic GMP;Development;Evaluation;manufacture;National Center for Advancing Translational Sciences;preclinical safety;Process;Qualifying;Reference Standards;Reporting;Route;Scheme;Technology Transfer

PROJECT_TITLE: CHEMISTRY, MANUFACTURING, AND CONTROLS (CMC) DEVELOPMENT OF NCGC00413972 FOR PRECLINICAL SAFETY EVALUATION AND CLINICAL TRIAL


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: INTEGRATED LABORATORY SYSTEMS, LLC

ORG_STATE: NC

PHR: This contract provides supports the activities of the Division of Translational Toxicology (DTT) hazard identification activities (i.e., evaluating the harmful effects of various chemicals or physical agents) targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents of public health concern.

PI_NAMEs: GEORGETTE, HILL  (contact)

PROJECT_TERMS: Adverse effects;Apoptosis;Autopsy;Cell Proliferation;Cellular biology;Chemicals;Consult;Contracts;Data;Development;developmental toxicity;disorder prevention;DNA;DNA sequencing;Electron Microscopy;Ensure;Environmental Exposure;Evaluation;Exposure to;Genotype;Government;Hazard Identification;Histology;Immunohistochemistry;immunotoxicity;In Situ;In Situ Hybridization;Journals;Laboratories;Laboratory Animal Medicine;Malignant Neoplasms;Manuscripts;Molecular Biology;molecular pathology;Morphology;National Institute of Environmental Health Sciences;National Toxicology Program;Pathology;Peer Review;Preparation;Procedures;Process;Public Health;Publications;Reporting;reproductive toxicity;Research Design;Research Personnel;research study;RNA;Services;Slide;Specimen;Stains;Support Contracts;System;Techniques;Time;Tissues;Toxic effect;Toxicology;Training;working group

PROJECT_TITLE: Pathology Peer Review and Pathology Support for the DNTP and DIR at NIEHS (Integrated Laboratory Systems an Inotiv Company)


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: OVERALL - PROJECT NARRATIVE The programs of the SCERC impact occupational health and safety in three ways: Our graduates contribute directly to worker safety and health through their employment as professionals in the field and many go on to assume leadership positions in business and various state and federal agencies. Our research contributes to longer term improvements in worker health through improved understanding of workplace exposures, health effects, and their control. Our Outreach and Continuing Education Programs facilitate the translation of research results into actual occupational and public health and safety practice.

PI_NAMEs: JONES, RACHAEL MARY (contact)

PROJECT_TITLE: Southern California Education and Research Center


ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative: Overall PUBLIC HEALTH RELEVANCE: The Harvard Chan ERC plays a vital role in the New England region as well as the nation in providing interdisciplinary education and training for graduate-level professions in key disciplines of occupational health and safety. This work is complemented by continuing education and outreach efforts in these key disciplines. The Center produces researchers and practitioners vital to maintaining workplace health and safety.

PI_NAMEs: CHRISTIANI, DAVID C (contact)

PROJECT_TITLE: Harvard TH Chan Education and Research Center for Occupational Safety and Health


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE – JOHNS HOPKINS ERC OVERALL Situated in the largest, most highly ranked school of public health in the world, the multidisciplinary Johns Hopkins Education and Research Center for Occupational Safety and Health prepares occupational safety and health professionals in the areas of research, education, practice, and policy development, and provides outreach and continuing education in occupational safety and health. Since its establishment in 1977, the Johns Hopkins ERC has evolved in response to changing demands in the field, as well as to scientific and technological advances that impact occupational safety and health practice, research, and education, while retaining steadfastly its commitment to an integrated, interdisciplinary approach to training researchers and practitioners. The Center addresses ongoing and emerging issues, thereby building the national capacity to provide care, set policy, design and manage safety and health programs, and conduct research to further the National Occupational Research Agenda and advance the body of knowledge in this field—and as the only ERC in federal region III, which includes Maryland, Washington, D.C., Virginia, West Virginia, Delaware, and Pennsylvania —we are dedicated to meeting regional as well as national and international needs, and our center’s Outreach and Continuing Education efforts serve hundreds of organizations each year within our region alone, including private-sector businesses, nonprofit and academic organizations, local, state, and federal government agencies, and the military.

PI_NAMEs: RAMACHANDRAN, GURUMURTHY  (contact)

PROJECT_TITLE: Johns Hopkins Education and Research Center for Occupational Safety and Health (JHU ERC)


ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative RMCOEH’s training, research training, Continuing Education, and Outreach directly align with the mission and goals of the National Institute of Occupational Safety and Health. The center with this application aims to further its significant positive impact on worker health and safety in the Department of Human Health Services’ Region 8 and beyond.

PI_NAMEs: HEGMANN, KURT  (contact)

PROJECT_TITLE: Rocky Mountain Center for Occupational and Enviromental Health


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Chronic Pain;Nanotechnology;Pain Research;Regenerative Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: CURER INC

PHR: Narrative The life quality of bone metastasis patients is extremely poor as metastasized tumor cells frequently fragilize the bone, causing intolerable pain and immobility. Currently, there is no effective treatment in the clinic to cure bone metastasis. To solve this important medical problem, we will develop next-generation cement material that can deliver anti-cancer drugs and restore the bone health of cancer patients to recover their lives.

PI_NAMEs: JANG, HAE LIN  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Address;aging population;American;anti-cancer;Antineoplastic Agents;Antitumor Drug Screening Assays;Area;Binding;biomaterial compatibility;bone;bone cell;Bone Cements;Bone Growth;bone health;Bone Pain;Bone Regeneration;Bone Substitutes;Bone Tissue;calcium phosphate;cancer cell;Cancer Etiology;Cancer Patient;Cementation;Cessation of life;Clinic;Clinical;commercialization;Data;developmental toxicity;Disseminated Malignant Neoplasm;Dose;Drug Delivery Systems;Drug toxicity;effective therapy;efficacy testing;Engineering;experience;FDA approved;Food and Drug Administration Drug Approval;Formulation;Fracture;healing;Health;high risk;Hospitals;Human;Human body;Hydroxyapatites;Immobilization;implant material;In Vitro;in vivo;in vivo Model;Injectable;innovation;invention;Licensing;Life;Malignant Neoplasms;manufacture;Mechanics;Medical;Medical Device;medical schools;meetings;Metastatic Neoplasm to the Bone;Methods;mid-career faculty;mimetics;mineralization;Minerals;minimally invasive;Mission;monomer;mortality;Movement;nanomedicine;nanoparticle;Neoplasm Metastasis;next generation;Notification;novel;Organ;Osteoclasts;Osteogenesis;Osteolysis;Osteolytic;Osteoporosis;Paget's Disease;Pain;pain reduction;particle;Particle Size;Pathway interactions;Patients;Pharmaceutical Preparations;Plexiglass;polymerization;Polymers;Polymethyl Methacrylate;Positioning Attribute;pre-clinical;Preclinical Testing;Preparation;prevent;Process;Production;professor;programs;prototype;Quality of life;Recovery Support;Regenerative capacity;reproductive;Research;Risk Assessment;scale up;Serious Adverse Event;side effect;Site;Small Business Technology Transfer Research;Standardization;Sterilization;Surface;System;systemic toxicity;targeted treatment;Technology;Therapeutic;Time;Toxic effect;Translating;Translations;tumor progression;United States National Institutes of Health;Validation;Woman

PROJECT_TITLE: Next generation anti-cancer drugdelivering cement for bone metastasis patients


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases;Stomach Cancer

ORG_CITY: Boston

ORG_NAME: COLLAGEN MEDICAL, LLC

PHR: Project Narrative Gastric cancer (GCa) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. The prognosis of patients with advanced GCa is poor with a median survival of 12-14 months even with combination chemotherapy. To address this unmet clinical need Collagen Medical is developing an image- guided therapy tool targeting the fibrin in the extracellular matrix of gastric tumors.

PI_NAMEs: HUMBLET, VALERIE  (contact)

PROJECT_TERMS: 90Y;Address;advanced disease;Beta Particle;Binding;Biodistribution;Blood Proteins;Cancer Etiology;Cancer Patient;Cessation of life;Clinical;clinical translation;Collagen;Combination Drug Therapy;Control Groups;Copper;Cyclic GMP;Cyclic Peptides;Data;Deposition;Derivation procedure;Detection;dosage;Dose;dosimetry;Drug Kinetics;Extracellular Matrix;Extravasation;Fibrin;Frequencies;Gastric Tissue;Histologic;Human;human model;Image;image guided therapy;Immunohistochemistry;improved;Injections;Kinetics;Legal patent;Licensing;Magnetic Resonance Imaging;Malignant Neoplasms;malignant stomach neoplasm;Measures;Medical;Methods;mouse model;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;Organ;Outcome;patient derived xenograft model;patient prognosis;Patients;Peptides;Phase;Positron-Emission Tomography;Prevalence;Prognosis;Radiation therapy;Radiolabeled;Rattus;response biomarker;Rodent;Safety;Signal Transduction;Specificity;Stomach Neoplasms;Targeted Radiotherapy;targeted treatment;theranostics;Therapeutic Effect;therapeutic target;Thrombus;Time;Tissue Microarray;Tissues;tool;Toxic effect;translational therapeutics;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;tumor;tumor growth;tumor microenvironment;uptake

PROJECT_TITLE: Theranostic for gastric cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(11)B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative: Coronaviruses can emerge from wildlife reservoirs and infect humans resulting in outbreaks of pneumonia, as we are experiencing with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We want to identify how coronaviruses evade the early warning system of the immune response. These studies will teach us how coronaviruses slip under the radar of our immune defenses and cause disease.

PI_NAMEs: BAKER, SUSAN C. (contact)

PROJECT_TITLE: Investigating Interferon Antagonists in Delaying Innate Immune Responses to SARS-CoV-2


NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Cancer Genomics;Clinical Research;Diabetes;Genetics;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Breastfeeding provides substantial protection against subsequent metabolic disease for mothers with obesity and/or diabetes and their babies, yet these women are at increased risk of inadequate milk production. The aims of this project will be to investigate the effects of maternal metabolic hormones on mammary development and function using cells derived from human milk and complementary in vivo and in vitro mouse models. Studies will be performed at a top tier program in lactation research and will identify interventional opportunities to improve lactation outcomes in an effort to decrease long-term metabolic risks for both mothers and their children.

PI_NAMEs: MARTIN CARLI, JAYNE FRANCES (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: adipokines;adiponectin;Affect;Animal Model;Apoptosis;Area;Automobile Driving;Biology;Body mass index;Breast biopsy;Breast Epithelial Cells;Breast Feeding;cardiometabolism;Cell Differentiation process;Cell Maintenance;Cell Physiology;Cell Separation;Cells;Child;Data;Development;Diabetes Mellitus;diet-induced obesity;Ensure;epidemiological model;epithelial stem cell;Equilibrium;Ethics;Exclusion;Failure;Fasting;Flow Cytometry;FRAP1 gene;Functional disorder;Future;Generations;Gestational Diabetes;Gland;Goals;health of the mother;High Fat Diet;High Risk Woman;Hormones;Human;Human Milk;human RNA sequencing;Human Subject Research;Hyperinsulinism;Immune;Impairment;improved;In Vitro;in vitro Model;in vivo;innovation;INSR gene;Insulin;Insulin Receptor;Insulin Resistance;insulin secretion;insulin signaling;intergenerational;Intervention;Investigation;knock-down;Knock-out;Lactation;lactation period;lactogenesis;Leptin;Life;Link;Liquid substance;mammary;Mammary gland;maternal diabetes;maternal obesity;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic hormone;Metabolism;Milk;milk fat globule;milk production;milk supply;Modeling;Molecular;Mothers;mouse model;Mus;Myoepithelial cell;Obese Mice;Obesity;Outcome;Pathway interactions;Performance;Phase;Phosphorylation;Physiological;Physiology;Play;Population;Postpartum Period;Pregnancy;Pregnancy in Diabetics;premature;progenitor;programs;Prolactin;protein activation;Proto-Oncogene Proteins c-akt;Recording of previous events;Research;Resistance;Risk;Role;Secretory Cell;Signal Transduction;single-cell RNA sequencing;Socioeconomic Factors;Study models;success;Technology;Tissues;Training;transcriptome sequencing;Woman;women's outcomes;Work

PROJECT_TITLE: Harnessing Cells from Human Milk; Linking Lactation to Metabolism


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PI_NAMEs: OBASI, EZEMENARI M (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TITLE: Evaluating Telemedicine  Related Opioid Use Disorder (OUD) Services in Underserved Populations: A Comparison  of Waiver and Post-waiver Periods


PROJECT_TITLE: Pilot proof of concept exploring longitudinal links between minority stress, stress physiology dysregulation, and drug use in sexual minority adults


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative The overall goal of this Center is to uncover and define the mechanisms by which epithelial genes contribute to the development, persistence, progression, remission, and resolution of allergic disorders so that effective strategies can be developed to prevent the onset and/or halt the progression of allergic disease.

PI_NAMEs: KHURANA HERSHEY, GURJIT K. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affect;Allergic;Allergic Disease;Allergic inflammation;allergic response;Atopic Dermatitis;Basic Science;Black race;Cellular biology;Child;Childhood Asthma;comorbidity;Data;Data Analyses;data integration;design;Development;Disease;Disease Progression;Disease remission;Doctor of Medicine;Doctor of Philosophy;Educational workshop;empowerment;Environment;epidemiology study;Epithelial Cells;Epithelium;Foundations;Funding;Genes;Goals;Heterogeneity;Homeostasis;Hypersensitivity;IgE;Individual;Inflammatory;Infrastructure;insight;Knowledge;Life;Longitudinal cohort;Molecular;novel;Organ;Pathogenesis;Pathway interactions;Pediatric Hospitals;Peptide Hydrolases;Phenotype;Play;Population;prevent;Prevention strategy;Principal Investigator;prospective;Protease Inhibitor;racial difference;receptor;Regulation;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Serine Proteinase Inhibitors;Skin;Surface;Testing;Therapeutic;therapy development;Tissues;Transcription Repressor;Translational Research;treatment strategy;United States National Institutes of Health;virtual

PROJECT_TITLE: Epithelial Genes in Allergic Inflammation


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Agreement;Allergic;Allergic Disease;Allergic inflammation;Asthma;Atopic Dermatitis;Award;Budgets;Child;Communication;Communication Programs;Cost Savings;Data Analyses;data integration;Dedications;Disease;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Expenditure;Funding;Funding Opportunities;Genes;Goals;Infrastructure;Institution;member;Monitor;National Institute of Allergy and Infectious Disease;Notification;Policies;Procedures;programs;Progress Reports;Regulatory Affairs;Reporting;Research;Research Personnel;Resources;Role;Structure;timeline;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Estrogen;Genetics;Immunotherapy;Lupus;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Loss-of-function of the Src-family kinase Lyn is associated with systemic lupus erythematosus (SLE), an auto- immune disease that is 10x more common in women than in men. We have discovered that the shorter isoform of Lyn (LynB) has a dominant function in maintaining immune balance in mice, whereas the longer isoform (LynA) confers specific protection to females. With the long-term goal of modulating the pro-inflammatory and pro-ho- meostatic functions of Lyn for potential therapies, we propose to define the unique signaling functions and sex- specific regulation of the two Lyn isoforms.

PI_NAMEs: FREEDMAN, TANYA S. (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Accounting;Adoptive Transfer;antagonist;antimicrobial;Autoimmune Diseases;Autoimmunity;Automobile Driving;Autophagocytosis;B-Lymphocytes;Cell membrane;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Confocal Microscopy;cytokine;Data;Dendritic Cells;Disease;Dose;Environment;Equilibrium;Estrogen Receptors;Estrogens;experimental study;Female;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;Homeostasis;hormonal signals;Human;Imiquimod;Immune;immunomodulatory therapies;immunoregulation;Immunosuppression;Inflammatory;ITAM;ITIM;Knock-out;Link;loss of function;Lupus;Macrophage;male;Maps;Mediating;Mediator;men;Modeling;monocyte;mouse model;Mus;Myeloid Cells;novel;novel therapeutics;Oligonucleotides;Ovariectomy;Oxygen;Pathway interactions;Pattern;Phagocytosis;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Pristane;Production;Progesterone;protein complex;Protein Isoforms;Proteins;Proteomics;Publishing;Reagent;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Rheumatology;RNA Splicing;Role;Second Messenger Systems;Series;sex;sexual dimorphism;Signal Pathway;Signal Transduction;Specificity;src-Family Kinases;Systemic Lupus Erythematosus;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;tool;Up-Regulation;Woman

PROJECT_TITLE: Functions of LynA and LynB kinases in dendritic-cell pro-inflammatory signaling and lupus


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Silicosis and asbestosis are progressive scarring diseases of the lungs caused by inhalation of silica and asbestos, respectively. Effective therapies are limited due to our incomplete understanding of the mechanisms that initiate and perpetuate the disease; however, scarring is thought to arise from impaired regeneration of the lung after injury. The objective of this application is to identify the specific mechanisms by which normal regeneration is impaired and promotes scarring in silicosis and asbestosis, thus identifying novel therapeutic targets.

PI_NAMEs: ZEMANS, RACHEL LYNNE (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Adopted;Alveolar;alveolar epithelium;Alveolus;Architecture;Asbestos;Asbestosis;Automobile Driving;Bleomycin;Cell Culture System;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Differentiation process;Cells;Cicatrix;Coculture Techniques;Data;Defect;Deposition;Development;Disease;Dust;effective therapy;endoplasmic reticulum stress;Epithelial Cell Proliferation;Epithelial Cells;epithelium regeneration;Feedback;Fibroblasts;Fibrosis;fibrotic lung disease;Genetic Markers;genetic signature;Goals;Human;human disease;idiopathic pulmonary fibrosis;impaired capacity;Impairment;Inhalation;Injury;Keratin;knockout gene;Knockout Mice;Lung;Lung Diseases;lung injury;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;new therapeutic target;novel;novel therapeutics;Organ;Pathogenesis;Patients;Phenotype;Positioning Attribute;prevent;Process;Proliferating;Pulmonary Fibrosis;regenerative;Resolution;Respiratory Failure;response;restoration;senescence;Signal Pathway;Signal Transduction;Silicon Dioxide;Silicosis;SOX4 gene;stem cells;Structure;Structure of parenchyma of lung;Testing;Time;transcriptome;Transforming Growth Factor beta;Transitional Cell;Work

PROJECT_TITLE: Mechanisms of Impaired Epithelial Regeneration and Fibrosis After Silica Dust Inhalation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-E(03)]


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative Exposure to fine particulate air pollution (PM2.5) is a leading cause of cardiovascular disease, respiratory disease, and premature death. This research will investigate potential links between PM2.5 composition, its ability to promote oxidative stress in the body, and its short-term and long-term health effects on a national scale. Results of this research should provide actionable insight into air pollution health effects and could provide policymakers with a more efficient means to protect public health.

PI_NAMEs: VOLCKENS, JOHN  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acidity;Acute;Acute myocardial infarction;Affect;Air Pollution;Asthma;Attention;Back;Biological Availability;burden of illness;Cardiometabolic Disease;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular health;Cells;Cessation of life;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;Cities;Classification;climate change;cohort;Cohort Studies;Communities;Complex Mixtures;Congestive Heart Failure;cost;Cost Measures;Cross-Over Studies;Data;demographics;Diameter;environmental justice;epidemiology study;Ethnic Origin;Ethnic Population;experience;Exposure disparity;Exposure to;fine particles;follow-up;Future;Geography;Guidelines;Health;Individual;insight;Intervention;Link;Location;Longitudinal Studies;low socioeconomic status;Malignant neoplasm of lung;Measurement;Measures;Medicare;Metals;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;Myocardial Ischemia;novel;Outcome;Oxidation-Reduction;Oxidative Stress;Participant;particle;Particulate;Persons;Policy Maker;Population;population health;premature;prospective;Public Health;Race;racial difference;racial population;Reaction;Research;Respiratory Disease;respiratory health;response;Risk;Risk Assessment;Risk Factors;Sampling;Shapes;Site;Socioeconomic Status;Source;Sulfur;Technology;Time;Tissues;Toxic effect;Trace Elements;Transition Elements;Variant

PROJECT_TITLE: PM2.5 Metals, Oxidative Potential, Exposure, and Risk Assessment (PM OPERA): A National Morbidity and Mortality Study

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Fluoride exposure is ubiquitous and has been associated with impaired neurodevelopment in children. Adolescence is an understudied life stage during which profound brain remodeling and behavioral development may be influenced by early life environmental factors such as fluoride. Leveraging the novel tooth biomarker, this will be the first study to assess longitudinal fluoride exposure starting in utero on neurodevelopment and brain structure in childhood and adolescence.

PI_NAMEs: BRUNST, KELLY J (contact);MARTINEZ, MAURO

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 12 year old;Address;Adolescence;Aggressive behavior;Amygdaloid structure;Animals;Anxiety;Apatites;Attention deficit hyperactivity disorder;Behavior;Behavioral;Biological Markers;Birth;Brain;brain remodeling;brain volume;calcification;Canada;Chemicals;Child;Childhood;cingulate gyrus;Cognition;Cognitive;cohort;Communities;cost effective;Data;deciduous tooth;Dental caries;Developed Countries;Development;early childhood;Elements;Emotions;Environment;Environmental Risk Factor;evidence base;Exposure to;Fluorides;follow-up;Food;gray matter;Growth;Histologic;Human;Hyperactivity;Impaired cognition;Impairment;improved;in utero;Intelligence;interest;Investigation;Knowledge;knowledge base;Life;Link;Magnetic Resonance Imaging;Maps;Measures;Mental Depression;Mexico;Modeling;neurobehavior;neurobehavioral;neurodevelopment;neuroimaging;neurotoxicity;novel;Obesity;Outcome;Participant;Policies;Population;postnatal;prenatal;prevent;preventive intervention;Process;Property;Public Health;Recording of previous events;repository;Reproducibility;Research;Research Design;Resolution;Resources;Role;Sampling;social stressor;Sodium Chloride;Spottings;Structure;Symptoms;Time;Tissues;tool;Tooth structure;United States;Urine;validation studies;Water;Water fluoridation;white matter;Work

PROJECT_TITLE: Longitudinal Impact of Fluoride on Neurodevelopment and Neuroimaging Outcomes During Childhood and Adolescence in the United States and Mexico

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Electronic Nicotine Delivery Systems;Neurodegenerative;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Tobacco;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Electronic cigarettes are a major risk factor that contributes to the vascular contributions to cognitive impairment and dementia. The purpose of this project is to determine the mechanisms by which electronic cigarettes through direct exposure or during in-utero maternal exposure contributed to aortic and cerebrovascular dysfunction and cognitive decline.

PI_NAMEs: CHANTLER, PAUL D (contact);OLFERT, I. MARK

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acceleration;Address;Adult;Aerosols;Affect;Age;Age Months;age related decline;Allopurinol;ameroid;Animal Model;Animals;Aorta;Area;Behavioral;behavioral outcome;Blood;Blood Vessels;Brain;Breathing;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Chronic;Cigarette;cigarette smoking;Circulation;Cognitive;cognitive function;combustible cigarette;Controlled Environment;Coupled;Critical Pathways;Data;Development;Devices;Disease;disorder risk;Dose;Electronic cigarette;electronic cigarette use;electronic liquid;Endothelial Cells;Endothelium;Environment;Environmental Exposure;Etiology;experimental study;FDA approved;febuxostat;Female;Foundations;Functional disorder;Generations;Goals;Health;Hepatic;Hepatocyte;High Prevalence;Human;Hydrogen Peroxide;hypoperfusion;Impaired cognition;Impairment;improved;in utero;interest;Knockout Mice;Life;Link;Liver;loss of function;male;Maternal Exposure;maternal vaping;Measures;Mediating;Mediator;Molecular;Monitor;mouse model;Mus;Neurobiology;never smoker;novel;offspring;old mice;Operative Surgical Procedures;Outcome;Oxidants;Pathogenesis;Pathologic;Pathology;Pathway interactions;Perinatal Exposure;Pharmaceutical Preparations;pharmacologic;Phenotype;Plasma;Play;Positioning Attribute;pre-clinical;Pregnancy;prenatal exposure;Prevalence;Production;Relative Risks;reproductive;Research;Resolution;Risk Factors;Rodent;Role;Safety;Smoker;Smoking;Source;Stenosis;Stress;Superoxides;System;Technical Expertise;Technology;Testing;Therapeutic;Time;Tissues;Toxic effect;United States National Institutes of Health;vaping;vascular bed;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;Woman;Work;Xanthine Oxidase;XDH gene;young adult;Youth

PROJECT_TITLE: Xanthine oxidase mediates the vascular dysfunction with direct and in-utero electronic cigarette exposure

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Healthy cells have numerous safeguards to slow or halt replication when faced with DNA damage or other forms of cellular stress. Many cancers, however, have the remarkable ability to tolerate high levels of DNA damage and other replication challenges imposed by environmental and endogenous agents, often at the cost of more mutations. Understanding the mechanisms by which cancer cells can accumulate mutations and become drug resistant may ultimately lead to new therapeutic approaches to this disease.

PI_NAMEs: CIMPRICH, KARLENE A (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Adopted;Affect;anti-cancer treatment;ATP phosphohydrolase;ATPase Domain;Binding;biological adaptation to stress;Biological Assay;Bypass;cancer cell;cancer initiation;Catalytic Domain;Cell Line;Cell Proliferation;cell type;Cells;Cellular Stress;chemotherapeutic agent;chemotherapy;cost;crosslink;Cytoprotection;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA fiber assay;DNA lesion;DNA replication fork;DNA-Directed DNA Polymerase;Drug resistance;egg;Electron Microscopy;Endogenous Factors;Ensure;Enzymes;Event;Exhibits;experimental study;Failure;Family;first responder;Genetic;Genetic Transcription;Genome Stability;Genomic Instability;Goals;helicase;Heritability;Impairment;In Vitro;insight;lens;Malignant Neoplasms;Maps;Mediating;Methods;Molecular;molecular imaging;Mutagenesis;mutant;Mutation;next generation;novel;novel therapeutic intervention;Organism;Oxidative Stress;Phenotype;Polymerase;Predisposition;prevent;Process;Proliferating;Proteins;Proteomics;Reactive Oxygen Species;Regulation;repaired;replication stress;Resistance;response;Role;sensor;single molecule;Stress;Structure;Testing;transcription factor;translocase;tumor progression;Tumor Suppressor Proteins;tumorigenesis;ubiquitin ligase;ubiquitin-protein ligase;Xenopus

PROJECT_TITLE: Regulation of the DNA damage Response

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: CORVALLIS

ORG_DEPT: BIOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Climate change is a major global health threat, particularly in low- and middle-income countries. The proposed research will establish a global climate-health study to assess the direct and indirect impacts of climate-driven exposures on human health using an existing global prospective cohort study. In addition, it will develop a framework for building resilience to climate change impacts on health in low-resource settings.

PI_NAMEs: HYSTAD, PERRY W (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Adult;Air Pollution;analytical method;Award;Chronic;Chronic Disease;Climate;climate change;climate disaster;climate impact;climate-related exposures;climate-related health;cohort;Communities;community-level factor;Complex;Country;Cross-Over Studies;Crossover Design;Data;Data Analyses;Data Collection;Data Set;Disasters;Disease;Droughts;Epidemiology;epidemiology study;Event;evidence base;experience;Exposure to;extreme temperature;extreme weather;Floods;Focus Groups;follow-up;Frequencies;Funding;Future;global health;Grant;hazard;Health;Health Policy;Health Surveys;Hospitalization;Household;HRK gene;Human;Incidence;Income;Individual;Infrastructure;Link;low and middle-income countries;meteorological data;Methods;modifiable risk;mortality;Outcome;Participant;Pathway interactions;Pattern;promote resilience;prospective;Prospective cohort;Prospective, cohort study;Rain;Research;Research Design;Research Personnel;resilience;resilience factor;Resource-limited setting;Resources;Risk Factors;Rural;Rural Community;Seasons;Surveys;Survival Analysis;United States National Institutes of Health

PROJECT_TITLE: PURE-Climate: Identifying and Adapting to Climate Change as a Modifiable Risk Factor for Human Health

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE:  Pyramidal neurons in the primary visual cortex (V1) undergo dynamic plasticity changes throughout visual associative learning. This proposal will define which learning events drive differential plastic changes in V1 and how learning or V1 activity shape cortico-cortical functional connectivity. We expect our findings to provide important insight into the behavioral underpinnings of V1 and cortico-cortical plasticity throughout learning.

PI_NAMEs: BATCHELOR, HANNAH MARIE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Plasticity of cortical networks during learning


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative Cancer health education can utilize digital media to inform. To address cancer disparities among Indigenous sexual and gender minority populations, health film approaches will be adapted to co- create between a cancer center health communications team, medical illustrators, and Two-Spirit and Indigenous LGBTQ+ influencers to increase cancer-based awareness.

PI_NAMEs: JOHNSON, CANDACE S (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Attitude;Awareness;Behavior;Cancer Center;cancer health disparity;cancer prevention;Colorectal Cancer;Communication;Communities;community advisory board;community based practice;community engagement;Community Health;Community Health Education;Community Outreach;digital media;digital repositories;Educational Models;Event;Film;gender minority community;gender minority group;gender minority health;Goals;Grant;Health;health care delivery;health communication;Health education;Imagery;Indigenous;indigenous community;intertribal;Knowledge;Language;Lesbian Gay Bisexual Transgender Queer;Malignant neoplasm of liver;Malignant Neoplasms;Medical;Modeling;NCI-Designated Cancer Center;outreach;Prevention;Resources;screening;Screening for cancer;Sexual and Gender Minorities;sexual minority group;social media;Societies;Surveys;System;Transportation;two spirit;Update

PROJECT_TITLE: Two-Spirit Films in Indigenous Cancer Health


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal is designed to establish an interdisciplinary training program in clinical pain research at Mass General  Brigham (MGB) in Boston. The long-term goal is to expand the number, diversity, and collaborative network of clinical  pain researchers, advancing our understanding of pain and our ability to effectively manage pain without opioid  medications. This program offers interdisciplinary mentorship and training in clinical pain research by bringing together a  diverse group of mentors from an array of backgrounds, including Psychology, Neurology, Neuroscience, Psychiatry,  Epidemiology to promote innovative solutions for pain management and improve patient care by providing high-quality  training to future leaders in clinical pain research.

PI_NAMEs: EDWARDS, ROBERT R (contact);SCHREIBER, KRISTIN

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Address;Boston;career;Chronic;clinical pain;Clinical Research;cohort;comorbidity;Dedications;design;Disabled Persons;disadvantaged background;effective intervention;Enrollment;Epidemiology;Ethnic Population;experience;Foundations;Funding;Future;Goals;health equity;improved;Individual;innovation;Learning;life span;Mentors;Mentorship;Neurology;Neurosciences;next generation;non-opioid analgesic;Nonpharmacologic Therapy;Pain;pain chronification;Pain management;Pain Research;Patient Care;peer coaching;Pharmacological Treatment;Positioning Attribute;Postdoctoral Fellow;prevent;Process;programs;Psychiatry;Psychology;racial population;Records;recruit;Research;Research Personnel;Research Training;responsible research conduct;social health determinants;Solid;Time;Training;Training Programs;Universities

PROJECT_TITLE: Mass General Brigham Interdisciplinary Clinical Pain Research Training Program