NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Clinical Research;Clinical Trials;Communicable Diseases;Consultations;Contractor;Control Groups;Data Analyses;Data Collection;Data Coordinating Center;data management;data quality;electronic data;Internet;Quality Control;Randomized;Research Design;Sample Size;Specimen;statistics;Stratification;System

PROJECT_TITLE: Statistical and Data Coordinating Center (SDCC) for Clinical Research in Infectious Diseases: SARS-CoV-2


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ROCKVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: THE EMMES COMPANY, LLC

ORG_STATE: MD

PI_NAMEs: EWELL, MARIAN  (contact)

PROJECT_TERMS: Clinical Research;Clinical Trials;Communicable Diseases;Consultations;Contractor;Control Groups;Data Analyses;Data Collection;Data Coordinating Center;data management;data quality;electronic data;Internet;Monkeypox;Quality Control;Randomized;Research Design;Sample Size;Specimen;statistics;Stratification;System

PROJECT_TITLE: Statistical and Data Coordinating Center (SDCC) for Clinical Research in Infectious Diseases: mpox


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Prevention

ORG_NAME: WESTAT, INC.

PI_NAMEs: MATHEW, SUNITHA  (contact)

PROJECT_TERMS: Address;Cessation of life;Contractor;Data Collection;data exchange;Data Linkages;data management;data repository;data submission;Databases;indexing;Institutional Review Boards;National Cancer Institute;neoplasm registry;Participant;participant retention;Process;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Screening for cancer;Telephone;United States Centers for Medicare and Medicaid Services;Update

PROJECT_TITLE: Support for the Central Data Collection Center (CDCC)


ADMINISTERING_IC: CK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: HADLEY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative The proposed project has great relevance to human health in that it seeks through applied research projects to advance progress across the six-state New England region in the prevention of bites, and suppression of populations, of ticks and other vectors that carry human disease agents. The research objective is to provide well-documented study findings regarding currently available technical approaches, emerging and novel technical approaches, methods involving host and/or habitat interventions, and approaches for heightening public acceptance and adherence, that public health practitioners and others can rely on in their work of combating vector-borne diseases in New England. The center’s other two objectives, training a new generation of medical entomologists and strengthening linkages and collaborative relationships with partners outside the academic community, are both of great relevance to human health in terms of growing the New England region’s human resource capacity to fight vector-borne diseases and growing a regional community of practice that includes state and local public health agencies.

PI_NAMEs: RICH, STEPHEN M (contact)

PROJECT_TITLE: CK22-005 New England Center of Excellence in Vector-Borne Diseases


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis that blocks the leg arteries and results in insufficient blood flow to the lower extremities. Limb ischemia from PAD is the most common disorder treated within the vascular surgical service of the Omaha Veterans Affairs Medical Center. PAD also accounts for one-third of the operations performed in the VA Medical Centers nationwide. The risk of mortality of veterans with PAD is substantial; nearly 30% of veterans with PAD died within 3.8 years of diagnosis. This project aims to establish the feasibility and acceptability of specially designed assistive shoes in patients with PAD and to determine if there are any potential benefits of using these shoes over standard shoes. These assistive shoes may enable patients to carry out desired activities of daily living with less pain and more physical activity. Increasing physical activity will decrease morbidity and mortality. If proven beneficial, our findings will lead to a novel and conservative rehabilitation protocol that directly benefits veterans nationwide.

PI_NAMEs: MYERS, SARA A (contact)

PROJECT_TERMS: absorption;Accelerometer;acceptability and feasibility;Activities of Daily Living;Acute;Adopted;analog;Ankle;Arteries;Atherosclerosis;Award;Biomechanics;Biopsy;Blood flow;Blood Vessels;carbon fiber;Cardiovascular Diseases;cardiovascular risk factor;claudication;Clinical Trials;Conduct Clinical Trials;Data;design;Diagnosis;Disease;Engineering;Exercise Therapy;Exertion;exoskeleton;Fatigue;Flexor;foot;functional independence;Gait abnormality;Gastrocnemius Muscle;Goals;implementation barriers;improved;improved mobility;instrument;Intermittent Claudication;Intervention;Interview;Ischemia;Leg;Length;limb ischemia;Lower Extremity;Measurement;Measures;mechanical properties;Medical center;Morbidity - disease rate;mortality;mortality risk;Muscle;Myalgia;Myopathy;Near-Infrared Spectroscopy;novel;novel therapeutic intervention;Older Population;operation;Orthotic Devices;Outcome;Pain;Pain in lower limb;Patient Care;Patient Preferences;Patients;Peripheral arterial disease;Physical activity;Pilot Projects;Population;Positioning Attribute;preference;pressure;Procedures;Protocols documentation;Quality of life;Questionnaires;Reaction;Recommendation;recruit;Rehabilitation therapy;Reporting;revascularization;sedentary;Self-Help Devices;sensor;Shoes;Specialist;standard care;Surgeon;surgical service;Symptoms;Testing;treadmill;Treadmill Tests;United States Department of Veterans Affairs;Veterans;Visual;walker;Walking;walking performance;Work

PROJECT_TITLE: Improving walking in peripheral artery disease using specially designed assistive shoes

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Lack of adherence to an exercise program is a major problem for older Veterans. Several fall prevention programs fail in the home setting due to lack of adherence. Exercise adherence is dependent on brain function among other factors. Magnetic stimulation of the front part of the brain improves brain function necessary for planning and following-through. [We propose a three-phase study in 106 sedentary older Veterans.] Everyone will be trained on use of the exergame, Nintendo Wii-Fit, that our team has found beneficial in improving balance and gait. They will be asked to exercise using Wii-Fit at home for 45 minutes daily five days/week for 12-weeks. [Those that exercise less than recommended dose and those that exercise adequately but have low executive function will receive either real or sham magnetic stimulation to the front part of their brain over ten sessions paired with exercise training.] All subjects will further complete 24-weeks of Wii-Fit home exercises. [Adherence, executive function, balance and gait, self-efficacy, delay discounting, and falls will be measured periodically.]

PI_NAMEs: PADALA, KALPANA P. (contact)

PROJECT_TERMS: Adherence;Attention;Behavior Control;Behavior Therapy;Biological;Brain;clinical practice;Cognitive;Communities;Complex;cost;Data;design;Diabetes Mellitus;discounting;Dose;Double-Blind Method;Equilibrium;evidence base;Executive Dysfunction;executive function;Exercise;exercise adherence;exercise program;exercise training;exergame;fall injury;Fall prevention;falls;fear of falling;flexibility;Gait;Home;Hospitalization;human old age (65+);improved;Incidence;Individual;Intervention;Knowledge;Learning;Link;Magnetism;Measures;Memory;Methods;Morbidity - disease rate;mortality;Motivation;Motor Cortex;neural network;neuroregulation;novel;older adult;Outcome Measure;Parkinson Disease;Patient Self-Report;Patients;performance tests;Phase;Pilot Projects;Placebos;post stroke;Prefrontal Cortex;Prevention program;primary outcome;problems and exercises;processing speed;programs;Psyche structure;Randomized;Recommendation;repetitive transcranial magnetic stimulation;response;Rewards;Role;Safety;safety assessment;Schedule;sedentary;Self Efficacy;Supervision;Techniques;Testing;Time;Training;translational study;Travel;treatment comparison;Veterans

PROJECT_TITLE: Neuromodulation for Exercise Adherence in Older Veterans

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: This project tests Brasthesis, a new product for women Veterans with upper limb loss. Brasthesis incorporates the harnessing straps that hold the prosthesis to the body into a heavy-duty sports bra. The position of the harnessing straps are individualized for each woman so that the prosthesis can be positioned for optimal contact between the prosthetic sensor and the residual limb. One woman who was unable to wear a traditional prosthesis reported that Brasthesis was comfortable and that she was able to wear her clothes over Brasthesis without feeling like a football player. We foresee Brasthesis being available as an adaptable sports bra that comes with a goodie bag of spare parts that can be used to customize Brasthesis. Brasthesis will be inexpensive so that Veterans can have more than one in a variety of colors. Brasthesis is machine washable.

PI_NAMEs: HECKMAN, JEFFREY T. (contact)

PROJECT_TERMS: 3-Dimensional;Accelerometer;Affect;Air Bags;Amputation;Anatomy;Area;arm;Arteries;Axilla;Blood flow;Breast;Case Series;Chest;Clinical Data;Clothing;Code;Color;Contusions;Custom;Cyst;Data;design;Exclusion Criteria;experience;Fat necrosis;Feedback;Feeling;Female;Future;Gender;Genetic Transcription;Goals;Hematoma;Hemorrhage;Hour;Human Milk;Hybrids;improved;inclusion criteria;Industry;Informed Consent;injured;Injury;interest;Interview;Legal patent;Length;limb amputation;limb loss;Limb Prosthesis;Limb structure;Link;Literature;Mammary Duct;Mammary Gland Parenchyma;Manufactured football;Maps;Names;neuromuscular;novel;Oils;open wound;Outcome;Outcome Measure;Participant;Patients;phenomenological models;Positioning Attribute;powered prosthesis;pressure;Procedures;Process;Prosthesis;Prosthesis Design;prosthesis fitting;prosthesis wearer;prosthetic alignment;prototype;Proxy;Reporting;Research;residual limb;Resources;satisfaction;Seat Belts;sensor;Shoulder;Side;Skin;Sports;Structure;Surface;Swelling;Technology;Technology Transfer;Telephone;Testing;theories;Thrombophlebitis;Time;tissue injury;Training;Trauma;Upper Extremity;Veins;Veterans;Voice;Woman;Writing

PROJECT_TITLE: Brasthesis Prototype for Women Veterans with Upper Limb Amputations


FUNDING_MECHANISM: OTHERS

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Mild traumatic brain injury (mTBI) is one of the most common conditions afflicting combat veterans. Though most individuals experience a full recovery after mTBI, a so-called “miserable minority” experience persistent symptoms of post-concussive syndrome (PCS), even after pursuing rehabilitative treatment. Growing evidence suggests that the presence of non-injury factors, such as mental illness, might cause PCS symptoms to persist. As such, genes that confer risk for conditions related to mTBI (such as posttraumatic stress disorder) could be used to predict mTBI outcomes and recovery. This proposed project will seek to identify the extent that genetic risk for related conditions predicts the persistence of PCS as well as outcomes from mTBI treatment. Identifying factors that could predict mTBI outcomes and recovery would have great utility for clinicians, as it would allow them to make more informed and personalized decisions about treatment recommendations.

PI_NAMEs: DISNER, SETH GORDON (contact)

PROJECT_TERMS: active duty;Address;Affect;Afghanistan;Alleles;Alzheimer's Disease;Attention deficit hyperactivity disorder;Biological Factors;Bipolar Disorder;Candidate Disease Gene;Caring;Categories;Childhood;Chronic;Clinic;Clinical;Cognitive;combat veteran;Communities;comorbidity;Complex;computerized;Craniocerebral Trauma;Data;Department of Defense;Development;Diagnosis;Disease;disorder risk;Education;Effectiveness;Environment;environmental stressor;Etiology;European ancestry;experience;Failure;falls;follow-up;gene environment interaction;Genes;Genetic;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;Genome;genome wide association study;genome-wide;Genotype;Health;Healthcare Systems;Impairment;improved;indexing;Individual;Injury;innovation;Intelligence;Intervention;Iraq;Light;Link;Literature;Major Depressive Disorder;Mental disorders;mild traumatic brain injury;Military Personnel;military veteran;Minority;Multiple Trauma;Nervous System Trauma;neural;Neurologic;Neurological status;Outcome;Outpatients;Parkinson Disease;Participant;Pattern;persistent symptom;Personal Satisfaction;personalized decision;personalized intervention;personalized predictions;Persons;Phase;phenome;Phenotype;phenotypic data;Physical Medicine;Physical Rehabilitation;Play;polygenic risk score;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;precision genetics;Prediction of Response to Therapy;Prevalence;psychiatric genomics;psychologic;Psychopathology;Quality of life;Recommendation;Recording of previous events;Records;Recovery;Recovery of Function;recruit;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation service;Rehabilitation therapy;rehabilitative care;Relative Risks;Research;Risk;risk variant;Role;Sampling;Schizophrenia;service member;Source;Sum;Symptoms;Syndrome;Testing;theories;Time;trait;Trauma;traumatic event;United States Dept. of Health and Human Services;Validation;Variant;Veterans;whole genome;Work;working group

PROJECT_TITLE: Exploring polygenic risk as a means for personalizing TBI rehabilitation

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Relevance of the Proposed Work to the VA Patient Care Mission. Hearing loss is among the top service- connected disabilities in Veterans. Hearing aids are the primary intervention for hearing loss. Half of the hearing aids dispensed in the VA are to Veterans who are receiving replacement amplification. Many Veterans would like their replacement hearing aids mailed to them, but they are required to travel to the clinic so that the fit of the hearing aid can be verified. There are standard fitting procedures, such as those used in infants and children, that use a coupler to simulate the patient's real ear to verify the hearing aid fitting. The results of this study should determine the efficacy of a coupler-based hearing-aid fitting protocol that would not require the Veteran to attend the fitting appointment, thereby contributing to improved Veteran-Centric care.

PI_NAMEs: QUINN, CANDICE MANNING (contact)

PROJECT_TERMS: active control;Address;Adult;Affect;Appointment;Audiology;Caring;Child;Client satisfaction;Clinic;cost;Coupling;Custom;Data;disability;Ear;efficacy evaluation;evidence base;experience;experimental study;External auditory canal;Frequencies;Hearing Aids;hearing impairment;Improve Access;improved;In Situ;Individual;Infant;Intervention;Logistics;Measurement;Measures;Methods;Minor;Mission;Modeling;Outcome;Outcome Assessment;Output;Participant;Patient Care;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Patients;Pilot Projects;Procedures;programs;Protocols documentation;Publishing;Reporting;Research;response;Sampling;service delivery;Services;standard of care;System;Testing;Time;Tinnitus;Travel;Tube;Variant;Vent;Veterans;Visit;Wait Time;Work

PROJECT_TITLE: Efficacy of a coupler-based fitting approach for experienced users receiving replacement hearing aids

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: There are over 1,600 major limb amputations to-date in military operations OEF, OIF, and OND (CRS Report). Additionally, in 2013 alone there were nearly 27,000 (QUERI) Veterans with spinal injuries (SCI) and related disorders cared for by Veterans Affairs who all stand to benefit directly from this project. This Merit Award project aims to build fundamental knowledge of how motor cortex (MI) controls voluntary, as well as stereotypic, lower limb movements, and then to design both a brain-spine interface leveraging a fully implanted hardware system combining wireless neural recording, stimulation, and motion capture technologies borrowed from industry and born from our laboratory, with the mathematical tools to explore use of a neuroprosthetic for therapeutic delivery of spinal stimulation. By establishing a robust understanding of the cortical control of hind limb movement, and piloting a fully implanted brain-spinal interface, we will have obtained the critical scientific information needed to advance toward a first-in-human study of a restorative BSI in Veterans with paraplegia.

PI_NAMEs: BORTON, DAVID ALLENSON (contact)

PROJECT_TERMS: Address;Affect;Amputation;Amputees;Animals;Area;Attention;Automobile Driving;Award;Axon;Behavior;Behavioral;Body mass index;Brain;brain control;brain machine interface;Breathing;Calibration;Caring;Classification;Clinical Research;clinical translation;Cortical Cord;Custom;Data;Data Set;design;Development;disabled;Disease;Economics;Electric Stimulation;Electrocorticogram;Electromyography;Electronics;Failure;feature extraction;first-in-human;flexibility;Follow-Up Studies;foot;functional restoration;Future;Gait;Health;Home;Hospital Costs;Human;human study;Implant;Individual;Industry;insight;instrument;Intention;Joints;kinematics;Knowledge;Laboratories;Lead;Leg;Life;limb amputation;limb loss;limb movement;Limb Prosthesis;Limb structure;Location;Locomotion;locomotor tasks;Lower Extremity;Macaca;Macaca mulatta;Malignant Neoplasms;Maps;Mathematics;Medical;Methods;Microelectrodes;military operation;military veteran;Modality;Modeling;Motion;Motor;motor control;Motor Cortex;motor rehabilitation;Movement;Muscle;Nervous System;Nervous System Trauma;neural;neural implant;Neurons;neuroprosthesis;Neurostimulation procedures of spinal cord tissue;neurotechnology;nonhuman primate;Palpable;Paraplegia;Pathway interactions;Pattern;Performance;Periodicity;Persons;Phase;Physiologic pulse;Play;Population;Positioning Attribute;pre-clinical;Primates;Process;Prosthesis;Publishing;Quality of life;Rehabilitation therapy;Reporting;Robotics;Role;Rotation;sensor;Signal Transduction;Silicon;social;spatiotemporal;Spinal;Spinal Cord;Spinal cord injury;Spinal Injuries;Stereotyping;System;Technology;technology platform;Therapeutic;Time;tool;Training;training data;Translations;transmission process;Trauma;treadmill;two-dimensional;United States;United States Department of Veterans Affairs;Upper Extremity;Upper limb movement;Validation;Vascular Diseases;Vertebral column;Veterans;Walking;wireless;wireless data transmission;Work

PROJECT_TITLE: The Role of M1 Leg Area in Volitional and Stereotyped Control of the Lower Limb

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The need for moral injury interventions is increasingly being recognized as a domain in Veteran care that must be addressed. Consequences of exposure to morally injurious events include risk for suicide, substance abuse, and refractory symptoms of PTSD and depression.1-5 Exposure to morally injurious events is also highly prevalent among Veterans.8-9 Thus, interventions addressing moral injury are crucial to helping Veterans build meaningful lives. Psychotherapies explicitly targeting moral injury and functional recovery associated with this construct are limited in VHA. The proposed study serves as a first step in addressing this gap in the literature through the development of a recovery-oriented, evidence-based treatment approach for moral injury among warzone Veterans who report functional impairments related to moral emotions. The proposed pilot study will evaluate the acceptability of this intervention and the feasibility of the design for a future study to test the treatment's capacity to improve patients' functioning.

PI_NAMEs: BARNES, SEAN ;BORGES, LAUREN  (contact)

PROJECT_TERMS: acceptability and feasibility;active control;Address;Aftercare;arm;authority;Behavior;Belief;Caring;Client satisfaction;Clinical;clinically significant;Cognition;community reintegration;Consent;Data;depressive symptoms;design;Development;Diagnostic;Disease;Distress;Dose;Educational process of instructing;efficacy study;efficacy testing;efficacy trial;Eligibility Determination;Emotions;Enrollment;Esthesia;Evaluation;Event;evidence base;Evidence based intervention;Evidence based treatment;experience;Exposure to;Feeling suicidal;follow up assessment;follow-up;Functional impairment;Future;Goals;high risk behavior;Impairment;improved;in vivo;Individual;Information Systems;injury recovery;interest;Intervention;Interview;Learning;Literature;Maintenance;Manuals;Measurement;Measures;Mental Depression;Military Personnel;military veteran;Moral injury;Morals;Nature;Outcome;Outcome Measure;Pain;Participant;Pathologic;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;Pilot Projects;Population;Post-Traumatic Stress Disorders;power analysis;provider adherence;psychologic;psychosocial;Psychotherapy;Questionnaires;Randomized;randomized controlled design;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;reduce symptoms;Refractory;rehabilitation research;Reporting;Research;research and development;Research Design;response;retention rate;Risk Factors;Sample Size;Self Care;Shame;skills;social;Social Functioning;social learning;Specific qualifier value;Spirituality;Structure;Substance abuse problem;substance use;suicidal behavior;suicidal risk;Symptoms;Syndrome;Testing;Thinking;Time;trial design;United States National Institutes of Health;Veterans;Visit;War;Work

PROJECT_TITLE: Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GALVESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Public Health Relevance: Our studies are designed to establish the spatiotemporal relationship between posttranslational modification of key DNA repair proteins during metabolic and inflammatory dysregulation in the brains of Huntington’s disease patients and mice. Defects in the posttranslational modification process of DNA repair proteins and lack of an endogenous metabolite in neuronal cells could play causal roles in the development of Huntington’s disease. Understanding the molecular mechanisms underlying this DNA repair pathway should facilitate the development of novel therapeutic strategies to prevent the onset or treatment of Huntington’s disease, that are causally linked to genomic instability.

PI_NAMEs: HAZRA, TAPAS K (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Age;age related;Animal Model;autosome;Biological;Brain;Brain Diseases;brain tissue;Cell Death;Cells;Cessation of life;Chromatin;Complex;Corpus striatum structure;Data;Defect;design;Development;differential expression;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Modification Process;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA Repair Pathway;DNA strand break;Double Strand Break Repair;Drosophila genus;Enzymes;experimental study;Fructose;Fructose-2,6-bisphosphatase;Genes;Genetic Transcription;Genome;genome wide association study;Genomic Instability;Glycolysis;Human;Huntington Disease;Huntington gene;Hyperactivity;IkappaB kinase;In Vitro;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Inherited;inhibitor;Knowledge;Link;Machado-Joseph Disease;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Modeling;Molecular;Movement;Multiprotein Complexes;Mus;mutant;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuroinflammation;neuron loss;Neurons;neuroprotection;neurotoxicity;Nonhomologous DNA End Joining;Normal Cell;novel;novel therapeutic intervention;Nuclear Extract;Outcome;overexpression;Participant;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phospho-Specific Antibodies;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;polyglutamine;Polynucleotide 5'-Hydroxyl-Kinase;Post-Translational Protein Processing;postmitotic;prevent;Proteins;public health relevance;Regulation;repaired;Reporting;Role;Serine;Site;spatiotemporal;Testing;Therapeutic Intervention;Toxic effect;transcriptome sequencing;Transgenic Organisms

PROJECT_TITLE: DNA double strand break repair deficiency and neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Stroke

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Childhood arterial ischemic stroke is a devastating disease with recurrence and many non-overlapping injury mechanisms compared to both perinatal or adult arterial ischemic stroke due to the age-related differences in the maturation of the CNS and the immune system; there are no treatments to ameliorate suffering and decrease the enormous cost to families and society. Thromboctomy can be beneficial, but can produce adverse effects if delayed. The proposed experimental studies aim to fill the gap in knowledge of safe timeline for thromboctomy to enhance long-term repair in affected children.

PI_NAMEs: VEXLER, ZINAIDA S (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;acute stroke;Adolescent;Adult;Adverse effects;Adverse event;Affect;Age;age difference;age related;Animal Model;aptamer;Attenuated;Beds;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Edema;Brain Injuries;brain repair;Caring;Case Series;CDK6-associated protein p18;cerebral arteriopathy;cerebral artery;Cerebral hemisphere hemorrhage;Cerebrum;Child;Childhood;Chronic;clinically relevant;Collaborations;cost;Dependence;Development;Disease;Disputes;DNA Binding;drug efficacy;Edema;effective therapy;efficacy evaluation;endovascular thrombectomy;evidence base;experimental study;extracellular;Extracellular Matrix;Extravasation;Family;Female;ferric chloride;Functional disorder;functional outcomes;Funding;Genes;Goals;Hemorrhage;Histologic;Hour;Human;Immune;Immune signaling;Immune system;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;Ischemia;Ischemic Stroke;Knowledge;Late Effects;Leukocyte Elastase;Leukocytes;Ligands;loss of function;Magnetic Resonance Imaging;male;Mechanics;Mediating;Methodology;Microcirculation;Middle Cerebral Artery Occlusion;mimetics;Modeling;monocyte;mouse model;multimodality;Mus;myelination;neuroinflammation;Neurological disability;neuroprotection;Neuroprotective Agents;neurovascular;neutrophil;novel;novel therapeutics;Outcome;Paint;Pattern;Perinatal;perinatal ischemic stroke;Peripheral;pharmacologic;Phenotype;Play;postnatal;protective effect;randomized, clinical trials;Rattus;Recurrence;repaired;Reperfusion Injury;Reperfusion Therapy;Risk;Role;Safety;Science;Selection Bias;Series;Signal Transduction;SIV;Societies;Stroke;stroke clinical trials;stroke model;Therapeutic Agents;Thrombectomy;Thrombotic Stroke;Thrombus;Time;timeline;TLR3 gene;TLR4 gene;transcriptome sequencing;uptake;Viral;women subjects;Work

PROJECT_TITLE: Childhood arterial ischemic stroke: role of TLR4-neutrophil axis in injury and hemorrhagic transformation

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Neurological diseases are associated with mutations in enzymes that add and remove a tag called ubiquitin to proteins in the cell. This project focuses on determining how the breakdown of interconnected activities of certain genes (the ubiquitin ligase RNF216 and the deubiquitinase OTUD4) lead to disruptions in neural functions associated with the human neurological disorder Gordon Holmes syndrome (GHS). Completion of this work will expand our understanding on how enzymes that add and remove ubiquitin tags work together to regulate neural functions and will further facilitate therapeutic targets for neurological conditions associated with ubiquitin disruption.

PI_NAMEs: MABB, ANGELA M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Ataxia;Atlases;Automobile Driving;autosome;Biological;Biological Assay;Biological Process;Biology;Breeding;Caring;cell growth regulation;Cell Physiology;Cells;cellular targeting;Chemicals;Code;Data;Dementia;Deubiquitination;Disease;Engineering;Enzymes;Estrus;Frontotemporal Lobar Degenerations;Functional disorder;gain of function;Genes;Genetic;Half-Life;Human;hypothalamic pituitary gonadal axis;Hypothalamic structure;Impairment;Individual;innovation;insight;Knock-out;Knockout Mice;Knowledge;Lead;Link;Mammals;Maps;Measures;Messenger RNA;Microglia;Modeling;Modification;mouse model;Mus;mutant;Mutate;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neuropathogenesis;Neurophysiology - biologic function;Neurosecretory Systems;new therapeutic target;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Periodicity;Phenotype;Post-Translational Protein Processing;Process;Proteins;Proteomics;reproductive;reproductive function;Role;Series;Signal Transduction;Site;Syndrome;Testing;therapeutic target;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Viral;Work

PROJECT_TITLE: Protein ubiquitination and deubiquitination in neurological disorders

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Infectious Diseases;Malaria;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Brain injury due to cerebral malaria (CM) contributes significantly to childhood death and disability in sub-Saharan Africa, but multiple therapeutic trails have failed to demonstrate approaches that improve outcomes. Our recent work has highlighted that, in addition to commonly accepted mechanisms of neurologic injury, abnormal cerebral blood flow and dysregulated metabolism are ubiquitous. This project aims to establish these as novel mechanisms of neurologic injury, identify putative metabolites, and develop clinically relevant endotypes that encompass the heterogeneity of this disease, necessary steps that lead to the utilization of targeted, mechanistic specific adjunctive therapeutic approaches.

PI_NAMEs: OBRIEN, NICOLE  (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Acute;Affect;Africa South of the Sahara;African;Amino Acids;Anti-malarials;Behavioral;Biological;Biological Availability;Biological Markers;Blood Flow Velocity;Blood Vessels;blood-brain barrier disruption;Brain Injuries;Case Fatality Rates;Categories;Cerebral Malaria;cerebral oxygenation;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Cessation of life;Child;Childhood;Clinical;clinical care;clinically relevant;Cluster Analysis;Cognitive;cohort;Convalescence;Coupled;Coupling;Data;Death Rate;Development;disability;Disease;disease heterogeneity;efficacious treatment;Epilepsy;Equation;Erythrocytes;Goals;improved;improved outcome;Individual;Injury;innovation;insight;Integration Host Factors;Ischemia;Laboratories;Left;Lipids;Machine Learning;Malaria;Measurement;Measures;Metabolic;Metabolic dysfunction;metabolic rate;Metabolism;metabolomics;Microvascular Dysfunction;mitochondrial dysfunction;Morbidity - disease rate;Morphology;mortality;motor deficit;Near-Infrared Spectroscopy;Nervous System Trauma;Neurologic;Neuropathogenesis;neuroregulation;neurovascular;novel;Outcome;outcome prediction;Oxygen;Oxygen Consumption;Parasites;Pathogenesis;Pathologic;Patients;Pattern;Peptides;Perfusion;Phase;Physiological;point of care;point of care testing;Population;portability;precision medicine;randomized, clinical trials;response;Risk;Shunt Device;Site;Survivors;Test Result;Testing;Therapeutic;therapeutic target;Time;Transcranial Doppler Ultrasonography;treatment response;Work

PROJECT_TITLE: Determining Mechanisms of Cerebral Blood Flow and Metabolism Derangements in Pediatric Cerebral Malaria (FLOW)

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Urologic Diseases

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: KING'S COLLEGE LONDON

ORG_ZIPCODE: WC2R 2LS

PI_NAMEs: KANTH, SHEEBA  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Advocate;Africa;African;African ancestry;anti-cancer research;Antibodies;biobank;Biological;Biological Tumor Markers;black patient;Black race;Blood;Blood specimen;Breast;British;Cancer Biology;cancer health disparity;Cell Communication;Cells;charity care;Clinical;cloud based;cohort;Collaborations;college;Communities;community engagement;Complex;computer framework;Consent;Data;Data Element;data repository;Databases;design;Development;digital;digital pathology;DNA;early onset;Ecosystem;Education;Education and Outreach;Environment;Environmental Exposure;Epigenetic Process;Equity;Flow Cytometry;Gene Expression;Genetic;genome sequencing;genomic data;Genomics;Geographic Locations;Geography;Germ Lines;health determinants;Health Surveys;Healthcare;Histologic;Immune;Immune response;Immunoassay;Immunologic Factors;Immunologics;Immunophenotyping;improved;Incidence;Inequality;Inequity;Informed Consent;insight;Intervention;Joints;Link;Lived experience;London;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Molecular;Natural Selections;Non-Malignant;Not Hispanic or Latino;novel;outcome disparities;outreach;Pancreas;pancreatic cancer patients;Pathogenicity;Pathologic;Pathologist;Patient advocacy;Patient Care;Patient Self-Report;Patients;Plasma;Policies;Policy Developments;Population;precision oncology;Predisposition;pressure;Primary Neoplasm;profiles in patients;Prostate;Race;racism;recruit;Refractory;Research;Research Personnel;Research Support;Resources;response;Sampling;Science;Scientist;Secure;Shapes;Site;social;social determinants;social factors;social health determinants;social influence;Specimen;Standardization;structural determinants;structural health determinants;Surveys;sustainability framework;Technology;Tissue Microarray;Tissues;tool;Touch sensation;transcriptomics;Translational Research;treatment and outcome;trial design;Trust;tumor;Tumor Biology;Tumor Tissue;Underserved Population;Universities;virtual;Vision;whole genome;Work

PROJECT_TITLE: C07 - Societal, Ancestry, Molecular and Biological Analyses of Inequalities: SAMBAI


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: FARMINGTON

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The superficial zone of articular cartilage is critical for synovial joint maintenance, but it remains poorly understood how superficial zone cells regulate this function or why they are susceptible to irreversible damage that leads to cartilage disease. This project will investigate roles of superficial zone cells using genetically modified mice and single-cell RNA sequencing to identify characteristics and describe mechanisms. The resulting information will prove useful to conceive and test effective strategies that target superficial zone cells for articular cartilage repair and prevention of further deterioration in congenital and acquired joint diseases.

PI_NAMEs: RUX, DANIELLE RENAE (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acute;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;age-related disease;Alleles;analytical tool;Antigens;arthropathies;articular cartilage;Articular Range of Motion;Biological;Biology;Candidate Disease Gene;career;cartilage development;Cartilage Diseases;cartilage repair;Cell Communication;Cell Count;Cell Death;Cell Lineage;Cell Physiology;Cell Proliferation;Cells;Cellular Assay;Cessation of life;Characteristics;Chondrocytes;Cilia;Clinical;confocal imaging;Data;Degenerative polyarthritis;Deterioration;Development;Diphtheria Toxin;Disease;Embryo;Embryonic Development;environmental change;experimental study;fibroblast growth factor 18;Foundations;Future;Gene Expression Profile;Gene Modified;Growth;Growth and Development function;Histology;Image;In Situ Hybridization;in vivo;Injury;insight;Intervention;Joint Capsule;joint function;Joints;Knee;Knowledge;Label;Lead;Life;Link;LoxP-flanked allele;Lubricants;Lubrication;Maintenance;mature animal;mechanical load;mechanical signal;Mechanics;Medial meniscus structure;mineralization;Modeling;mosaic;mouse model;Movement;Multiple Abnormalities;Mus;mutant;nanoindentation;nanomechanics;nanoscale;Neonatal;old mice;Pathologic;Pathology;Pattern;Perception;Phase;Phenotype;Population;postnatal;postnatal development;Predisposition;Prevention;progenitor;Proliferating;Property;Proteoglycan;Quality of life;Recovery;repaired;Reporter;Research;resilience;response;Role;Running;sedentary;Signal Transduction;single-cell RNA sequencing;skeletal movement;smoothened signaling pathway;Solid;stem cell population;Structure;subchondral bone;Synovial joint;targeted treatment;Testing;Therapeutic;Thinness;Time;Tissues;Tomatoes;transcriptome sequencing;Transgenic Organisms;translational medicine;Traumatic Arthropathy;Traumatic injury;Work

PROJECT_TITLE: Roles of the superficial zone in mature articular cartilage

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_DEPT: PEDIATRICS

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE – OVERALL The Universities, Hospitals and Community Organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Using the targeted resources of an IDeA-CTR Award, the Brown Institute for Translational Sciences, and a statewide consortium of collaborators, hospitals, universities, non-profit organizations and government agencies, will draw on the resources already developed in the NIH Institutional Development Award (IDeA) programs (core labs and faculty development programs) to enhance the Advance Clinical and Translational Research Program’s (Advance-CTR) ability to support clinical and translational research. We will serve as a bench-to-bedside research network and career development umbrella for the investigator community in affiliated institutions. In so doing, we will enhance patient-centered research and accelerate discoveries and health innovations to benefit our communities and to serve our State.

PI_NAMEs: ROUNDS, SHARON IRENE SMITH (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Area;Award;Basic Science;bench to bedside;Big Data;Biological;biomedical informatics;Biometry;career;career development;Caring;Clinical;clinical application;Clinical effectiveness;clinical infrastructure;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community engaged research;community engagement;Community Mental Health Services;community organizations;Community Outreach;Core Facility;cost;COVID-19;Data;demographics;Development;Discipline of Nursing;Education;Environment;Epidemiology;Evolution;Extramural Activities;Fostering;Funding;Funding Opportunities;Future;Goals;Government Agencies;Grant;Health;health care delivery;health disparity;health equity;Health Policy;Health Priorities;Health Services;Health system;Healthcare Systems;Home;hospital organization;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;laboratory development;life span;Mentors;Modeling;multidisciplinary;National Institute of General Medical Sciences;New England;Nonprofit Organizations;organizational structure;Outcome;patient oriented;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;prevent;Productivity;Program Development;Program Evaluation;programs;Protocols documentation;Public Health;Publications;Research;Research Design;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Resources;Rhode Island;Services;success;synergism;Teacher Professional Development;Testing;Training;Translating;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Universities;virtual;Vulnerable Populations

PROJECT_TITLE: Advance Clinical and Translational Research (Advance-CTR)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project narrative Infectious diarrhea and bacteremia remain serious public health concerns in children and immunocompromised adults, but the lack of animal models that accurately resemble the infection observed in these patients have limited our understanding of the disease. We propose the use of novel neonatal and immunodeficient mice to study the pathogenesis and immune response during enteric and systemic infection by Citrobacter rodentium and Salmonella enterica serovar Typhimurium. These studies have the potential for a major impact on the design of better strategies to treat these conditions in children and patients with impaired adaptive immunity.

PI_NAMEs: CABALLERO FLORES, GUSTAVO  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute;Acute Diarrhea;adaptive immunity;Adult;Affect;Animal Disease Models;Animal Model;Animals;Award;Bacteremia;Bacteria;bacterial genetics;Bioinformatics;Biological Assay;Candidate Disease Gene;career;career development;Cells;Child;Chronic;chronic infection;Citrobacter rodentium;clinically relevant;clinically significant;Communication;complement C2a;Cytometry;Data Analyses;design;Diarrhea;Disease;disease model;Disease Progression;Educational process of instructing;Enteral;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Environment;Escherichia coli EHEC;Faculty;Genes;Genetic;genome wide screen;Goals;Grant;gut colonization;Health;Host Defense;Human;human pathogen;Immune;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;immunodeficient mouse model;Immunoglobulin G;Immunoglobulins;Immunologic Memory;Immunology;Impairment;In Vitro;in vivo;Individual;Infant;Infection;Inflammation;Inflammatory;inflammatory milieu;insight;Institution;intestinal barrier;Intestinal Diseases;intestinal homeostasis;Intestines;Laboratories;Lead;Life Style;mature animal;Mentors;Michigan;microbial;Modeling;Morbidity - disease rate;mortality;mouse model;Mucosal Immune Responses;Mucosal Immunity;Mus;Mutant Strains Mice;Mutation;National Institute of Allergy and Infectious Disease;Neonatal;neonatal mice;neonate;novel;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;pediatric patients;Play;Positioning Attribute;Predisposition;Preparation;programs;protective effect;Public Health;pup;Qualifying;Research;research and development;Role;Salmonella;Salmonella typhimurium;Scientist;single-cell RNA sequencing;skills;Study models;Systemic disease;Systemic infection;Techniques;Technology;Testing;tissue repair;Training;transposon sequencing;Universities;Virulence;Virulence Factors

PROJECT_TITLE: Deciphering the pathogenesis of an enteric pathogen in neonatal and immunodeficient mice


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: ALTRUMED LLC

ORG_STATE: PA

PHR: NARRATIVE Overdose with opioids (drugs similar to morphine, such as heroin) causes subjects to stop breathing enough and suffocate. An antidote to opioid overdose, naloxone, is widely distributed, but it requires a bystander to identify a person overdosing, obtain naloxone, and inject it properly; all within < 5 minutes to prevent brain damage, and somewhat longer to prevent death. Therefore, we have invented the DOVE device, which is an armband that detects opioid overdose and automatically injects the antidote, and we will further develop and test it here.

PI_NAMEs: BRENNER, JACOB  (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Academia;Accelerometer;Antidotes;Asphyxia;Brain Injuries;Breathing;Cadaver;Cessation of life;Collaborations;deltoid muscle;Device Designs;Devices;Diagnosis;Epidemic;Event;Family suidae;Fatty acid glycerol esters;FDA approved;Freedom;Grant;healthy volunteer;Heroin;Hypoventilation;Hypoxemia;Hypoxia;Industry;Interview;invention;Marketing;Modeling;Morphine;Muscle;Naloxone;Obstructive Sleep Apnea;Opioid;opioid mortality;opioid overdose;opioid user;Overdose;Paper;Patients;Persons;Pharmaceutical Preparations;Physiologic pulse;Positioning Attribute;preference;prevent;Probability;prototype;Publishing;Pulse Oximetry;Reproducibility;Ring Finger Domain;Sales;sensor;Shapes;Shoulder;Skin;Sleep;Small Business Technology Transfer Research;Specific qualifier value;Structure;Technology;Testing

PROJECT_TITLE: The DOVE Device to Prevent Opioid Overdose Deaths: An Armband That Senses Overdose and Automatically Injects Naloxone


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Complementary and Integrative Health;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition

PHR: Project Narrative Identification of diet-dependent mechanisms of commensal bacterial immune modulation could provide insight into autoimmune diseases such as inflammatory bowel disease and multiple sclerosis. Our study aims to investigate diet-dependent microbial mechanisms of Th17 cell activation, their consequences on mouse models of inflammatory bowel disease and multiple sclerosis, and relevance to human autoimmunity. The successful completion of our studies will provide important insight into novel bacterial mechanisms of Th17 induction and will probe whether dietary manipulation of bacterial immune-modulation represents a potential intervention for autoimmune diseases.

PI_NAMEs: ALEXANDER, MARGARET ROSE (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Actinobacteria class;Address;Adhesions;Area;Arginine;Autoimmune Diseases;Autoimmune Process;Autoimmunity;Bacteria;Bacterial Genes;bacterial genetics;Bacterial Infections;beta-Hydroxybutyrate;Bifidobacterium;Cells;clinically relevant;Collaborations;Data;Development;Diet;dietary;Dietary Factors;dietary manipulation;Disease;disease model;empowerment;Environment;Enzymes;Fasting;Genetic Diseases;genetic manipulation;Genetic Research;Goals;Growth;gut bacteria;gut colonization;gut microbiome;gut microbiota;Health;Human;human disease;Human Microbiome;Immune;immune activation;Immune response;Immune system;Immunity;Immunologics;Immunology;immunoregulation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;insight;Institution;inter-individual variation;Intervention;Intestines;ketogenic diet;Ketone Bodies;Link;Mediating;member;Metabolism;metabolomics;Microbe;microbial;Microbiology;microbiome;microbiome alteration;microbiome composition;microbiome research;microbiota;microorganism;Microscopy;Modeling;mouse model;Multiple Sclerosis;multiple sclerosis patient;murine colitis;Mus;novel;Patients;Positioning Attribute;Postdoctoral Fellow;prevent;Production;programs;protective effect;protein intake;Research;research study;Role;Seminal;Severities;Severity of illness;skills;small molecule;Techniques;Terpenes;Training;Translational Research;Work

PROJECT_TITLE: Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SIOUX FALLS

ORG_NAME: CIRCLE CLINICAL, LLC

ORG_STATE: SD

PHR: Project Narrative This project seeks to advance equity in clinical trials by identifying and addressing barriers to clinical trial participation experienced by urban American Indians at a clinical research site embedded within an urban indian health clinic. The project will engage urban AI individuals and will be influenced by Indigenous cultural values of respect, relationship, responsibility, reciprocity and redistribution. The goal of this exploratory research project will be to identify barriers to participation in clinical trials of urban AI communities and to identify solutions to address those barriers through a trusted relationship with a community research worker.

PI_NAMEs: BARTHOLOW, LYNN  (contact)

PROGRAM_OFFICER_NAME: HSIEH, JULIE

PROJECT_TITLE: Identifying and addressing barriers to clinical trial participation of Urban American Indians by creating a community research worker role

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (01)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetics;Health Services;Heart Disease;Human Genome;Prevention;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

PHR: PROJECT NARRATIVE (unchanged from currently approved project) This project will develop a lab test to determine a person’s genetic risk for 6 common diseases. The test will then be used in a clinical trial to identify patients at high genetic risk for at least one of these diseases. This trial will study whether the genetic test helps primary care providers diagnose these diseases earlier.

PI_NAMEs: VASSY, JASON L (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: arm;Atrial Fibrillation;Belief;Clinical;Clinical Management;Clinical Trials;Colorectal Cancer;Coronary Arteriosclerosis;cost;Diagnosis;Disease;disease diagnosis;evidence base;Genetic Risk;genetic testing;Genotype;Health behavior;high risk;implementation outcomes;Knowledge;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;medication compliance;Non-Insulin-Dependent Diabetes Mellitus;Odds Ratio;Outcome;participant enrollment;Patients;Persons;point of care;polygenic risk score;pragmatic randomized trial;Primary Care;primary care provider;Provider;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;screening;Testing;Time;treatment as usual;usual care arm

PROJECT_TITLE: Pragmatic randomized trial of polygenic risk scoring for common diseases in primary care


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE There is no effective medical therapy that modifies the progression of calcific aortic valve disease (CAVD), which requires an undesirable surgical intervention. We have recently discovered that targeting cadherin-11 can prevent CAVD in preclinical mouse models. We propose that cadherin-11 is a robust target for developing a novel therapy for CAVD.

PI_NAMEs: MERRYMAN, WILLIAM D (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;age related;Age Years;alpha Actin;aortic valve disorder;Biological Markers;cadherin-11;Cardiovascular Diseases;Cell Communication;Cells;Clinical Trials;Development;Elderly;Future;Heart Valve Diseases;human old age (65+);interstitial cell;Intervention;Medical;mouse model;Myofibroblast;novel therapeutics;Operative Surgical Procedures;Pathology;Patients;Persons;pre-clinical;prevent;Smooth Muscle

PROJECT_TITLE: Cadherin-11 in calcific aortic valve disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PI_NAMEs: BIRNBAUM, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;Alanine;algorithm development;algorithm training;Algorithms;Antigen Presentation;Antigen Targeting;Antigens;Base Sequence;Benchmarking;Biochemical;Biology;cancer therapy;cancer type;Collection;combinatorial;Complex;Computer Models;Computing Methodologies;cross reactivity;cytotoxicity;Data;Data Collection;Data Set;design;Development;Engineering;Event;extend lifespan;Face;Feedback;Generations;Goals;Grant;Healthcare;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunodominant Antigens;Immunology;Immunotherapy;improved;insight;Institution;large scale data;Libraries;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;Methods;Modeling;Molecular;mouse model;Mutation;next generation;novel drug class;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;Physics;prediction algorithm;predictive modeling;Proxy;quantum;receptor binding;Research Personnel;Resolution;response;Scanning;single cell sequencing;Source;Specificity;structural biology;Structural Models;Structure;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;TCR Activation;Testing;Therapeutic;therapy design;tool;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Validation;Virus;Vision;Work;Yeasts

PROJECT_TITLE: MATCHMAKERS - Creating and training AI tools for TCR binding prediction and design


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

PHR: PROJECT NARRATIVE  The objective of this study is to determine the effect of Medicaid policy changes enacted in response to the COVID-19 pandemic for Marshallese COFA migrants. The study builds on the work done since Medicaid expansion to understand the effects of the policy change on Medicaid enrollment and healthcare utilization among Marshallese COFA migrants. Additionally, findings will be used to inform programmatic interventions to ensure equitable access to healthcare services for COFA migrants.

PI_NAMEs: ANDERSEN, JENNIFER AUDREY (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Effects of COVID-19 Related Medicaid Policy Changes in the Marshallese COFA Migrant Population

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE We aim to use a 2x2 factorial design to test an acceptable and feasible peer support evidence-based intervention (EBI)—peer health coaching—to determine the preliminary effectiveness of different implementation strategies, as well as the overall EBI, at promoting self-care behaviors and improving glycemic control among older adults with type 2 diabetes living in Appalachian Kentucky. The main components of the factorial design will be how peer coaches are selected for participants (self-selected vs matched) and frequency of contact with coach (once per week vs every 2 weeks). Guided by the Practical, Robust Implementation and Sustainability Model (PRISM), we will collect quantitative and qualitative data to assess PRISM domains and give context to both anticipated and unanticipated EBI adaptations.

PI_NAMEs: KRUSE-DIEHR, AARON ;SMALLS, BRITTANY L. (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;Appalachian Region;Behavior;Clinical;Clinical Trials;Communities;Community Health;cost;Data;design;diabetes self-management;Diagnosis;Dimensions;Disease;Education;Effectiveness;Emotional;Ensure;Environmental Risk Factor;Evidence based intervention;Familiarity;Feedback;Frequencies;General Population;glycemic control;Glycosylated hemoglobin A;Goals;Health;human old age (65+);implementation evaluation;implementation outcomes;implementation strategy;improved;Individual;Intervention;intervention cost;Kentucky;Literature;Measures;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Overutilization of Health Services;Participant;peer;peer coaching;peer support;post intervention;Practical Robust Implementation and Sustainability Model;Prevalence;primary outcome;Process;psychosocial;Psychosocial Factor;psychosocial outcome;Questionnaires;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Resources;response;Rural;Rural Appalachia;Rural Community;rural dwellers;rural residence;Self Care;service organization;skills;social;Social support;Source;Structure;Testing;trustworthiness;Vulnerable Populations

PROJECT_TITLE: Diversity Supplement for Courtney Ortz: Older Adults Using Social Support to Improve Self-Care (OASIS): Adaption, Implementation, and Feasibility of Peer Support for Older Adults with T2DM in Appalach

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative  Using mouse models carrying specific regional genomic changes associated with congenital human craniofacial disorders, this project will gain new understanding of genome structure and function crucial for craniofacial development. The new findings will lead to improvement in clinical diagnosis, medial assessment, genetic counseling, and treatment of patients with craniofacial and other developmental disorders.

PI_NAMEs: JIANG, RULANG  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 3-Dimensional;Adoption;Affect;Binding;Binding Sites;Caring;Cephalic;Chromosomes;Clinical;clinical diagnosis;Code;cohesin;Complex;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;Data;Defect;Development;developmental disease;Diagnostic;Disease;Distal;DNA;DNA Binding;Ectopic Expression;Elements;Embryo;Embryonic Development;Enhancers;Exhibits;Face;Family;Frontonasal dysplasia;Gene Expression Regulation;Gene Structure;Genes;Genetic Counseling;Genome;genome editing;genome sequencing;genomic data;Genomic Segment;Genomics;Heterozygote;Histones;homeodomain;Human;Human Genome;improved;in silico;insight;Intercistronic Region;Kidney;Link;Maps;Medial;Mediating;Medical;member;Mesenchyme;microdeletion;Modeling;Molecular;Molecular Diagnosis;mouse model;Mus;Neighborhoods;Neural Crest Cell;novel;Orbital separation excessive;orofacial;Pathogenicity;Patients;Pattern;Phenotype;prevent;promoter;Proteins;Reporting;Role;Structure;Syndrome;Tail;Technology;Testing;transcription factor;Transcriptional Regulation;Untranslated RNA;Variant;vertebrate genome;whole genome

PROJECT_TITLE: Genomic and Developmental Mechanisms of SIX2-Related Frontonasal Dysplasia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE As a court-ordered remedy to address years of consumer fraud, several major tobacco manufacturers are required to display “corrective statements” in about 220,000 tobacco retailers across the US between October 2023 – July 2025, which will inform consumers about the health risks of tobacco and the tobacco industry’s history of deception. This time-sensitive study will use a variety of research methods, including retailer audits, eye-tracking, and longitudinal surveys with adults and youth, to examine the implementation, reach, and impact of this unprecedented retail-based intervention. Study results can help inform future large-scale tobacco information dissemination efforts, as well as identify subpopulations who may benefit from supplemental health education programs or other services.

PI_NAMEs: GIOVENCO, DANIEL PHILIP;MERCINCAVAGE, MELISSA ;WACKOWSKI, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Accountability;Address;Adult;Affect;Age;Agreement;Attention;Attitude;Baseline Surveys;Behavior;Belief;Cessation of life;Characteristics;Cigarette;cigarette smoke;Code;commercialization;Communication;Communities;Contracts;court;Data Collection;Deception;Decision Making;demographics;density;Disease;Education;Exposure to;Eye;follow-up;Fraud;Funding;Future;Goals;Health;health communication;Health education;health equity;Image;Individual;Industry;Influentials;Information Dissemination;Intervention;intervention delivery;Justice;Knowledge;Laboratories;Legal;Litigation;Longitudinal Surveys;Malignant Neoplasms;manufacture;Manufacturer;Marketing;Measures;Methodology;Nature;Neighborhoods;New Jersey;New York City;Newspapers;Outcome;Patient Recruitments;Perception;Persons;Phase;premature;Prevalence;programs;Protocols documentation;Public Health;Recording of previous events;remediation;Reporting;Research;Research Methodology;response;Risk;Running;Sales;Sampling;Series;Services;Smoke;Smoking;Smoking Behavior;Stimulus;Surveys;Television;Text;Time;Tobacco;Tobacco Industry;Tobacco use;United States;US State;Variant;Visit;Visual;visual tracking;Youth

PROJECT_TITLE: Implementation, reach, and impact of court-ordered tobacco corrective statement postings at the point-of-sale

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-Z (57)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Intestinal parasites, including soil-transmitted helminths (STH), infect over 1.5 billion people worldwide, resulting in a massive global burden of disease. Mass drug administration (MDA) to at-risk populations is the cornerstone of the global strategy for controlling morbidity associated with STH infections; however, varied MDA program success indicates that re-infection from environmental reservoirs is common. This proposal leverages a novel, sensitive and specific molecular assay to detect STH DNA in large volumes of soil within a multi-country community- wide MDA randomized controlled trial to define, for the first time, the impact of an MDA intervention on soil reservoirs of STH, and to evaluate the potential for using soil STH DNA as a non-invasive surveillance tool to monitor human infection prevalence.

PI_NAMEs: AJJAMPUR, SITARA SWARNA RAO;IBIKOUNLÉ, MOUDACHIROU ;PICKERING, AMY J. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adherence;Affect;Area;Biological Assay;burden of illness;Collection;Communities;cost;cost comparison;cost effective;Country;COVID-19 pandemic;Data;Detection;detection method;Diagnostic;DNA;Effectiveness;egg;enteric pathogen;Epidemiology;Evaluation;Feces;field study;Foundations;Geography;helminth infection;Helminths;Home;Household;Human;Human Activities;improved;India;Individual;Infection;infection rate;infection risk;Infrastructure;Intervention;Intestinal parasite;Intestines;Laboratory Study;Location;Measurement;Methods;Modeling;Molecular;Molecular Analysis;Monitor;Morbidity - disease rate;novel;Only Child;Parents;Persons;Pharmaceutical Preparations;Population;Population Density;Populations at Risk;predictive modeling;Prevalence;prevent;Program Effectiveness;programs;Randomized, Controlled Trials;Recrudescences;Resources;Sampling;Sanitation;School-Age Population;Schools;Seasons;Site;Soil;soil sampling;Source;standard of care;stool sample;Study models;success;Surveillance Methods;Temperature;Testing;Time;tool;transmission process;Water;Water Supply

PROJECT_TITLE: Soil epidemiology: a new tool for environmental surveillance of soil-transmitted helminth infections in endemic settings.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Soil-transmitted helminth infections represents a significant global public health and economic burden. Therefore, there is an urgent need to improve our understanding of genetic and environmental modulators of type 2 cytokine-dependent immunity in order to identify novel preventative and therapeutic approaches for this group of infectious agents. Based on our new preliminary data, the focus of this proposal is to dissect the influence of diet-induced modulation of microbiota-derived metabolites in regulating type 2 cytokine responses and protective immunity to helminth infection.

PI_NAMEs: ARTIS, DAVID  (contact);GUO, CHUN-JUN

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: absorption;Acceleration;Acids;Address;Adoptive Cell Transfers;Allergic Disease;allergic response;Anemia;Antiinflammatory Effect;B-Lymphocytes;Bacteria;bile acid metabolism;Bile Acids;Biological;Biology;Blood Circulation;Brain;Cells;Chemicals;Cholic Acids;Chronic;cognitive function;Communicable Diseases;comparative;cytokine;Data;dehydroxylation;Deoxycholic Acid;Development;Diet;Dietary Component;Dietary Fiber;dietary requirement;Distant;Economic Burden;Economics;Environmental Risk Factor;eosinophil;Eosinophilia;Fermentation;Fiber;Gene Deletion;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Engineering;Germ-Free;Growth;helminth infection;Helminths;IgE;Immune;Immune response;Immunity;Immunoglobulin G;Immunologics;immunopathology;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;Individual;Indoles;Infection;infection rate;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Intestines;Inulin;Lymphoid Cell;Macrophage;Malnutrition;Mammalian Cell;Mediating;member;mesenchymal stromal cell;Metabolic;Metabolic Pathway;metabolomics;microbial;microbiota;microbiota composition;microbiota metabolites;mouse model;Mus;mutant;neglect;novel;overexpression;Parasites;Parasitic infection;Pathway interactions;Persons;Physiological;prevent;Production;Public Health;receptor;Regulation;response;Role;secondary metabolite;Site;Soil;Source;Stromal Cells;Testing;Th2 Cells;Therapeutic;Tissues;tool;transcriptional reprogramming;transcriptomics;transmission process;Volatile Fatty Acids

PROJECT_TITLE: Microbiota-derived metabolites and the regulation of host immunity and inflammation

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Infant Mortality;Lung;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE [from parent] Defective tracheal cartilage development leads to airway collapse during breathing, causing sudden death in infants. We will take genetic and molecular approaches to characterize how BMP signaling is well-orchestrated in directing the tracheal cartilage development. The outcome of the proposed studies will establish the knowledge base for practical therapeutic solutions.

PI_NAMEs: MISHINA, YUJI  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acceleration;Alternative Therapies;autosome;Breathing;Breeding;career development;Cartilage;cartilage development;Child;chondrodysplasia;Chondrogenesis;Death Rate;Disease;Erinaceidae;Esophagus;experimental study;extracellular;FK506;Funding;Genetic;Growth Factor;Healthcare;Impairment;Incidence;Infant Mortality;Knowledge;knowledge base;Lead;Ligands;Mesenchyme;Molecular;Mus;Mutant Strains Mice;Neonatal Mortality;novel;Online Mendelian Inheritance In Man;Operative Surgical Procedures;Outcome;parent grant;Parents;Patients;Pattern;pharmacologic;Play;prevent;Primitive foregut structure;Regulation;Resources;Role;Shapes;Signal Transduction;Structural defect;Sudden Death;Symptoms;Syndrome;Therapeutic;Tissues;Trachea;tracheomalacia

PROJECT_TITLE: Temporal regulation of BMP signaling in patterning the tracheal cartilage and pharmacological approaches to prevent tracheomalacia (DivSupp)


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Rehabilitation;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Although buprenorphine is an effective treatment for opioid use disorder (OUD), half of patients on buprenorphine return to drug use within six months. Ketamine is a medication that has shown promise as a treatment for psychiatric and substance use disorders, but it has not been tested in a full-scale clinical trial for patients with OUD on buprenorphine. Here we will conduct placebo-controlled trials of ketamine combined with Mindfulness-Oriented Recovery Enhancement, an evidence-based psychotherapy for OUD, to improve outcomes among treatment-resistant patients receiving buprenorphine.

PI_NAMEs: GARLAND, ERIC LEE (contact);NUNES, EDWARD V.

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: addiction;Adherence;Affect;alcohol use disorder;Anesthetics;antagonist;Attenuated;Awareness;Behavioral;Brain region;Buprenorphine;buprenorphine treatment;Clinic;Clinical Trials;Clinical Trials Network;Cocaine use disorder;cognitive control;Communities;community based treatment;Conduct Clinical Trials;Conscious;Controlled Study;Corpus striatum structure;Coupled;craving;cue reactivity;Data;design;Diphenhydramine;Disease;Distress;drug reward;Drug usage;effective therapy;efficacious treatment;efficacy testing;Ego;Electroencephalography;evidence base;experience;FDA approved;follow-up;Funding;glutamatergic signaling;Glutamates;Habits;Hallucinogens;illicit opioid;improved;improved outcome;indexing;Internal Medicine;Intervention;Intramuscular;Ketamine;Learning;Marketing;Mediating;medication for opioid use disorder;Mental Depression;mindfulness;Morbidity - disease rate;mortality;N-Methylaspartate;National Institute of Drug Abuse;neural;neuromechanism;Neuronal Plasticity;neurophysiology;novel;novel therapeutics;Opioid;opioid misuse;opioid use disorder;Outcome;overdose risk;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Placebo Control;placebo controlled trial;Placebo Effect;Placebos;prevent;primary outcome;Process;programs;psychiatric symptom;Psychiatric therapeutic procedure;Psychiatry;psychologic;Psychophysiology;Psychotherapy;Public Health;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;Relapse;relapse prevention;Research;Research Design;Resistance;response;reward processing;Rewards;Safety;Science;secondary outcome;Serious Adverse Event;Site;skills;standard care;Substance Use Disorder;synaptogenesis;Testing;Therapeutic;Training;treatment adherence;Treatment Efficacy;Treatment outcome;United States

PROJECT_TITLE: Targeting Treatment-Resistant OUD with Ketamine-Assisted Mindfulness-Oriented Recovery Enhancement

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-M (O1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Lung;Precision Medicine;Prevention;Rare Diseases;Sarcoidosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Sarcoidosis is systemic disease with a highly variable clinical presentation and disease course, and appears to have an increasing mortality rate. There are currently no reliable biomarkers to diagnose or predict disease severity/progression, which further complicates management. The aim of this work will be to use differentially expressed microRNAs and clinical characteristics followed longitudinally to create biomarkers that can improve clinical outcomes in individuals with sarcoidosis.

PI_NAMEs: LIN, NANCY WEIJIUN (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: accurate diagnostics;Address;Affect;Biological Markers;biomarker development;Biopsy;Bronchoalveolar Lavage;Caring;Cause of Death;Cells;Characteristics;Clinical;clinical care;clinical heterogeneity;Clinical Management;cohort;Cohort Studies;Complex;Data;Death Rate;Development;Diagnosis;diagnostic biomarker;Diagnostic Sensitivity;differential expression;Disease;Disease Progression;disorder control;Environment;Environmental Exposure;Epigenetic Process;Exclusion;Family;Foundations;Funding;Future;Genes;Genetic Predisposition to Disease;Genomic approach;genomic biomarker;Genomics;Goals;Grant;Granulomatous disease;Immune;Immune response;improved;Individual;Inflammatory;Interstitial Lung Diseases;Intuition;Linear Regressions;Longitudinal Studies;Lung;Lung Diseases;lung injury;Mediating;Methods;microRNA biomarkers;MicroRNAs;miRNA expression profiling;Morbidity - disease rate;mortality;next generation sequencing;Occupational;Organ;Outcome;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Physicians;Play;Process;Prognosis;Prognostic Marker;prognostication;Pulmonary Sarcoidosis;Race;Research;Research Design;Resolution;Respiratory Failure;Role;Sampling;Sarcoidosis;Scientist;Sensitivity and Specificity;Severity of illness;sex;skills;Statistical Data Interpretation;System;Systemic disease;Testing;Time;Tissues;Untranslated RNA;Validation;Work

PROJECT_TITLE: MicroRNA as Diagnostic and Prognostic Biomarkers in Sarcoidosis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative This document has not changed from the original submission and is not required by PA-23-189.

PI_NAMEs: PEREZ-EDGAR, KORALY E (contact);PERLMAN, SUSAN B

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TITLE: Understanding the Interplay between Parent and Child Contributions in Parent-Child Anxiety Transmission

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Opioids;Prevention;Stimulant Use and Misuse;Substance Misuse;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The combined opioid and stimulant use epidemic, is an escalating public health emergency with numerous biological and psychological drivers and consequences, which are amplified in people with HIV and other marginalized groups. This project seeks to test the ability of metformin, a widely used drug to treat diabetes for its ability to minimize the increased inflammation and dysregulated immune response that occur among people who inject drugs. The results from this project could provide a new modality to limit co-morbidities in these individuals and improve immune responses.

PI_NAMEs: EATON, ELLEN FLORENCE;KOBIE, JAMES J (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acceleration;Acute;Address;Aging;AIDS prevention;Animals;Antibodies;Antibody Response;antiretroviral therapy;Autoimmune Diseases;B-Lymphocytes;Behavior;Behavioral;Biological;C-reactive protein;Cardiovascular Diseases;Caring;Cell Physiology;Cells;Clinical;Clinical Trials;comorbidity;Complement;Development;Diabetes Mellitus;Drug Prescriptions;Drug usage;Effectiveness;Epidemic;FDA approved;Flow Cytometry;Future;Height;Hepatitis A;high risk;HIV;HIV Infections;HIV vaccine;Homeostasis;Human;Immune;Immune response;Immunity;Immunocompetence;Immunologics;immunopathology;improved;In Vitro;Individual;Infection;Inflammation;Inflammatory;Injecting drug user;injection drug use;insight;Intervention;Intoxication;Kidney Diseases;Liver diseases;Lymphocyte;Lymphocyte Function;marginalized population;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;Metformin;Modality;mTOR inhibition;Mucosal Immunity;Mucositis;Mucous Membrane;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;off-label use;Opioid;opioid epidemic;opioid use;Oral;Participant;pathogen;Pathogenesis;Persons;Pharmaceutical Preparations;Phenotype;Placebo Control;Placebos;Plasma;Pneumococcal vaccine;Population;Predisposition;primary endpoint;Proliferating;Proteomics;psychologic;public health emergency;Randomized;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;Recording of previous events;rectal mucosa;Rectum;Regulation;Resolution;response;restoration;Risk;Safety;Serology;Severities;Signal Transduction;Stimulant;stimulant use;substance use;System;systemic inflammatory response;Testing;therapy adherence;transcriptomics;vaccination outcome;vaccine development;vaccine response;Vaccines;Viral

PROJECT_TITLE: Assessment of metformin for restoration of immune homeostasis in HIV+ and HIV- individuals with a history of injection drug use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (A1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Mental Health;Neurosciences;Pediatric

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research will use two of the largest datasets on child and adolescent neurodevelopment in  existence to inform how puberty influences the development of the brain and emerging risk for mental illness.  Using measures of puberty and hormones, paired with multiple metrics of brain development, we will  disentangle the relationship between age, puberty, and hormone concentrations and brain development, and  establish how different measures of brain development interrelate across puberty. In addition, we will examine  the neurodevelopmental mechanisms that help explain why early puberty increases an individual’s risk for  mental health problems including depression and anxiety.

PI_NAMEs: BARCH, DEANNA ;SOMERVILLE, LEAH HELENE (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Age;Anxiety;Attention;Behavioral;Biological Assay;boys;Brain;Brain imaging;brain pathway;Child;Childhood;Clinical;cognitive development;cohort;connectome;Coupling;Data;data analysis pipeline;data modalities;Data Set;Development;emerging adult;Ensure;Ethnic Origin;Evaluation;Foundations;Funding;girls;Goals;Hormonal;Hormones;Human;human data;Individual;informant;Investigation;Link;Literature;Longitudinal cohort;Longitudinal Studies;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Methods;Modality;Modeling;multimodal modeling;multimodality;neurodevelopment;novel;Parents;Pathway interactions;Patient Self-Report;Process;Psychopathology;pubertal timing;Puberty;puberty transition;Race;Research;Risk;Sampling;Socioeconomic Status;Structure;Symptoms;System;Testing;Time;United States National Institutes of Health;Variant;Work;Youth

PROJECT_TITLE: Characterizing pubertal and age mechanisms of neurodevelopment and association with rising internalizing symptoms


ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Project Narrative Ménière disease, characterized by adult fluctuating asymmetric hearing loss associated with attack of vertigo is a debilitating disease for which the pathophysiology is still unknown. This collaborative effort aims to identify genetics variants of Ménière disease patients and their relation to transcriptomic and epigenetic regulation of the lateral wall. This project will allow us to gather preliminary data to investigate the pathogenesis of Ménière disease at the molecular level.

PI_NAMEs: STEYGER, PETER STEPHEN (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Adult;Affect;All of Us Research Program;Animals;asymmetric hearing loss;Atrophic;Auditory;Award;base;biobank;Biological Assay;Blood;Candidate Disease Gene;candidate identification;cell type;Cell Wall;Cells;Chromatin;Cochlea;Collaborations;Complex;Data;data integration;Data Set;Databases;Defect;Development;Diagnosis;Disease;Distal;Ear;Elements;Endolymph;Endolymphatic Hydrops;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;experience;experimental study;Faculty;Foundations;Functional disorder;Funding;Future;Genes;Genetic;genetic analysis;genetic architecture;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Goals;Health;health data;Hearing;hearing impairment;histone modification;Homeostasis;Hot Spot;Human;improved;Individual;Infrastructure;inner ear diseases;insight;Investigation;Knowledge;Labyrinth;Lateral;Lead;Learning;Ligaments;Link;Liquid substance;membranous labyrinth;Meniere's Disease;Modification;Molecular;mouse model;Mus;Mutation;Participant;Pathogenesis;Patients;Persons;Phase;Privatization;Production;progressive hearing loss;promoter;Quality of life;Regulation;Regulatory Element;Reporter;Research;Resources;Rickets;Science;single-cell RNA sequencing;Stria Vascularis;synergism;Temporal bone structure;Tinnitus;Tissue Banks;transcriptome;transcriptomics;translational scientist;United States;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Vascularization;Vertigo;vestibular system;whole genome

PROJECT_TITLE: The Translational Hearing Center


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PI_NAMEs: ELLEDGE, STEPHEN J (contact)

PROJECT_TERMS: Address;algorithm development;Algorithms;antigen binding;antigen detection;Antigen Presentation;Antigen Targeting;Antigens;Bar Codes;Binding;Biochemical;Biological;cancer therapy;cancer type;central tolerance;combinatorial;Computer Models;Computing Methodologies;Coupled;cytotoxicity;Data;Data Set;design;detection platform;Development;Education;Elements;Engineering;Epitopes;Event;extend lifespan;Face;Feedback;Generations;genotyped patients;Goals;Grant;high throughput screening;Human;human tissue;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologic Stimulation;Immunology;Immunology procedure;Immunotherapy;improved;In Vitro;in vivo;insight;Institution;large scale data;Libraries;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;Methods;Modeling;Molecular;mouse model;next generation;novel drug class;Patients;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;prediction algorithm;preservation;quantum;Recombinants;Research Personnel;response;screening;Sorting;Source;Specificity;structural biology;Structure;Synthetic Antigens;System;T cell reconstitution;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy design;Thymus Gland;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Validation;Vision;Work

PROJECT_TITLE: MATCHMAKERS: Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neck Pain;Neurosciences;Pain Research;Physical Activity

PHR: The proposed Administrative Supplement application aims to bolster the capabilities of Dr. Wren Burton, MPH, DC. This application targets a pivotal phase in Dr. Burton’s unique career trajectory, aiming to facilitate her progression to an independent clinician-researcher. The proposed activities of this Administrative Supplement, including sustained engagement in the parent trial and participation in complementary training opportunities, are designed to furnish Dr. Burton with essential proficiencies in clinical trial conduct, neuroimaging techniques, data analysis, and grant writing. These endeavors will position her for success in independent research pursuits.

PI_NAMEs: WAYNE, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Address;Administrative Supplement;Award;career;Caring;chiropracty;Chronic;chronic pain;Clinical Trials Design;Communities;Complementary Health;Conduct Clinical Trials;Data Analyses;Data Collection;data management;design;Development;experience;Funding;Future;Gait;Grant;hands-on learning;Health;Institutional Review Boards;Integrative Medicine;interest;Intervention;K-Series Research Career Programs;Manuscripts;member;Mentorship;Modality;Monitor;multimodality;National Center for Complementary and Integrative Health;Neck Pain;neuroimaging;Observational Study;older adult;Outcome Assessment;parent project;Parents;Participant;Patient Recruitments;Peer Review;Phase;Pilot Projects;Positioning Attribute;Process;Protocols documentation;Publishing;Research;Research Personnel;Safety;skills;study population;success;Tai Ji;Techniques;Time;Training;Training Activity;training opportunity;Treatment Protocols;Troglodytinae;United States National Institutes of Health;Writing

PROJECT_TITLE: Combined Chiropractic Care and Tai Chi for Chronic Non-Specific Neck Pain


ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Meiosis is a cell division program that is essential for the formation of both eggs and sperm and therefore critically important for human reproductive health. Errors during meiosis are a leading cause of miscarriages, infertility and birth defects such as Down syndrome in humans. This application will investigate the regulation of the synaptonemal complex, a structure required for promoting accurate meiotic chromosome segregation in most organisms from yeast to humans, thereby laying the foundation for the development of effective preventive strategies.

PI_NAMEs: COLAIACOVO, MONICA P (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;ASH1L gene;Biochemical;Caenorhabditis elegans;Cell division;Chromosome Pairing;Chromosome Segregation;Chromosomes;Congenital Abnormality;Conserved Sequence;Coupled;Cytology;Data;Deacetylation;Development;DNA Double Strand Break;Double Strand Break Repair;Down's Syndrome;egg;Ensure;Failure;Foundations;Funding;gene conservation;Genetic;Genetic Crossing Over;Genetic Recombination;Germ Lines;Goals;Health;Human;Infertility;insight;Link;Mediating;Meiosis;Meiotic Prophase I;Molecular;Molecular Structure;Molecular Target;N-terminal;Nematoda;novel;Organism;Positioning Attribute;Post-Translational Protein Processing;Prevention strategy;programs;Protein Acetylation;Proteins;Regulation;Reproductive Health;Role;sperm cell;Spontaneous abortion;Structure;Synaptonemal Complex;Yeasts

PROJECT_TITLE: Synaptonemal Complex Assembly and Function in Meiosis


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE  Mutations in the SHANK3 gene are a well-established risk factor for ASD. This proposal aims to delineate how SHANK3 deficiency causes cellular and molecular malfunctions that underlie abnormal neural circuitry and social and reward behaviors using two novel mouse models. These studies may lead to identifying novel therapeutic targets for treating social and reward deficits in ASD and other neuropsychiatric disorders.

PI_NAMEs: FOLKES, OAKLEIGH  (contact)

PROGRAM_OFFICER_NAME: O'NEILL, MEGHAN ELIZABETH

PROJECT_TERMS: autism spectrum disorder;Behavior;Behavioral;Behavioral Paradigm;Binding;Biological Assay;Bipolar Disorder;Calcium;Characteristics;Cues;Data;density;Dopamine D1 Receptor;Etiology;Exons;experimental study;Fragile X Syndrome;Functional disorder;Genes;Genetic;Goals;Image;Immunohistochemistry;in vivo;Investigation;Knock-out;Measures;metabotropic glutamate receptor 5;Methodology;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;neural circuit;Neurons;neuropsychiatric disorder;new therapeutic target;novel;Nucleus Accumbens;optogenetics;Point Mutation;Population;post-doctoral training;postsynaptic;preference;Proline-Rich Domain;Proteins;Psychological reinforcement;recruit;Research;Research Domain Criteria;Research Personnel;response;Rewards;Risk Factors;Role;scaffold;Scaffolding Protein;Schizophrenia;social;Social Behavior;social deficits;Social Interaction;Synapses;Techniques;Testing;Time;Western Blotting

PROJECT_TITLE: Investigations of Neuronal Ensembles and Shank3-Homer Scaffolds on Reward and Social Behavior in a Shank3 model of Autism


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative This research will improve our understanding of how, when, and in which contexts adolescents with mental health problems may inadvertently engage in digital dating abuse within their romantic relationships and, in turn, increase their mental health problems. This knowledge is essential for identifying intervention points to combat lifelong risk for mental health problems.

PI_NAMEs: HA, PHUONG THAO  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: abuse victim;Adolescent;adolescent mental health;Adverse effects;Age;Anxiety;Behavior;Black race;Cellular Phone;Characteristics;Code;Cognition;combat;Communication;Communication difficulty;Conflict (Psychology);contextual factors;Couples;Cues;cultural competence;Data;depressive symptoms;design;diaries;digital;digital communication;Distress;Ethnic Origin;Exhibits;experience;Feeling suicidal;Functional disorder;Future;harassment;High Prevalence;high risk;improved;Intervention;Jealousy;Knowledge;Latinx;Literature;Long-Term Effects;Longitudinal Studies;Measures;media use;Mental Health;Minor;Monitor;Nature;negative mood;non-verbal;Observational Study;Parents;Patient Self-Report;peer;peer support;Persons;Pilot Projects;pressure;prevent;Process;protective factors;racial identity;Research;response;Risk;Sampling;social culture;Social Environment;social media;Stress;Surveys;Technology;Text;Text Messaging;theories;Time

PROJECT_TITLE: Bidirectional effects between adolescent digital dating abuse dynamics and mental health

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (05)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Nanotechnology;Natural Products

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE This proposal seeks to develop a new data-driven structurally resolved approach to natural products discovery that will accelerate the development of bioactive small molecules. By searching for materials featuring structural scaffolds with established synthetic accessibility, and using those materials and machine learning to inspire more environmentally benign synthesis, the proposal will invert the normal workflow of natural products discovery and drug lead development which will be of high impact to human health outcomes.

PI_NAMEs: FOX, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Administrative Supplement;Analytical Chemistry;Benign;bioactive natural products;Biological;Biology;Centers of Research Excellence;Chemicals;Chemistry;clinical material;Collaborations;Complex;Data;Data Set;Delaware;Development;Disease;Electrodes;Environment;FDA approved;Foundations;Goals;Health;Heart;Human;human disease;In Vitro;in vivo;Industrialization;Influentials;Informatics;invention;Laboratories;Lead;Libraries;Machine Learning;Macromolecular Complexes;Mass Spectrum Analysis;Medicine;metabolomics;Metals;Methodology;Methods;Modification;Molecular;nanoparticle;Natural product discovery;Natural Products;Nevada;Nitrogen;novel;novel therapeutics;Organic Chemistry;Outcome;Outcomes Research;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Probability;prospective;quinoline;Reaction;Research;research clinical testing;Resources;scaffold;screening;small molecule;Source;Structure;Surveys;Sustainable Development;Therapeutic;Therapeutic Intervention;tool;Training;Universities

PROJECT_TITLE: Discovery of Chemical Probes and Therapeutic Leads, Phase II


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Center for Healthy Aging Behaviors and Longitudinal InvestigationS (CHABLIS) will promote research in the demography and economics of aging and assist junior scholars as they engage in this research domain. We draw on projects such as NSHAP and CCP to develop opportunities for scholars, both junior and senior, to collaborate on science and survey methods in a longitudinal context.

PI_NAMEs: MELTZER, DAVID O (contact);WAITE, LINDA J

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Aging;aging population;Area;Attention;Behavior;career development;Centers for Population Health;Chicago;Collaborations;Comprehensive Health Care;Data;Data Collection;Demographic Factors;Demography;design;Discipline;early-career faculty;Economic Factors;Economics;Evaluation;Future;Goals;Health;healthy aging;Individual;Influentials;Infrastructure;infrastructure development;innovation;Intervention Studies;Investigation;Joints;Lead;Life;Life Cycle Stages;Measurement;Medical;Medicine;member;Mentors;Methodology;Methods;next generation;Observational Study;older adult;Outcome;Persons;Physicians;Pilot Projects;Process;Productivity;Program Development;programs;Research;research and development;Research Support;Resources;Schools;Science;social;Social Sciences;Sociology;Survey Methodology;synergism;Universities

PROJECT_TITLE: Center for Healthy Aging Behaviors & Longitudinal InvestigationS (CHABLIS)