ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The formation of new nerve populations within and around solid tumors plays an active role in cancer development, progression, and treatment resistance. In the proposed study, we will identify the exact neuronal mechanisms that support tumor progression by enabling oral cancer cells to evade immune surveillance. This new knowledge will position us to develop impactful, rational treatment approaches to address the neural signaling responsible for the suppressive modulation of immune system and reestablish healthy equilibrium of oral tissues.

PI_NAMEs: AMIT, MORAN  (contact);CALIN, GEORGE A.

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Ablation;Address;Adrenergic Agents;Afferent Neurons;Axon;Biological Models;Biometry;Breast;calin;Cancer Biology;cancer cell;cancer genetics;Cancer Patient;cancer therapy;candidate identification;Cell Physiology;cell type;Cells;Cellular biology;Cellular Structures;Clinical;Communication;Complex;Cues;Cytotoxic T-Lymphocytes;Data;Development;Environment;Epithelium;Equilibrium;Event;extracellular vesicles;functional genomics;functional plasticity;Genes;genetic approach;Genetically Engineered Mouse;Genomic approach;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Homeostasis;Human;Imaging Techniques;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune response;Immune signaling;Immune system;Immunologic Surveillance;Immunology;immunoregulation;Immunosuppression;Immunotherapy;improved;in vitro activity;Induced Neurons;Infiltration;Inflammatory Response;innovation;insight;Knowledge;malignant mouth neoplasm;Malignant Neoplasms;Mediating;MicroRNAs;Molecular;molecular imaging;mouse model;mouth squamous cell carcinoma;neoplastic cell;Nerve;Nerve Fibers;nerve supply;Nervous System;neural;Neurobiology;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neuroimmune;neuromechanism;neuron loss;Neurons;neuroregulation;neurotransmission;neurotransmitter release;new therapeutic target;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Oral;oral cavity epithelium;oral tissue;Outcome;Pancreas;paracrine;Pathology;Patients;PD-1 blockade;Peripheral Nervous System;Persons;pharmacologic;Play;Population;Positioning Attribute;Pre-Clinical Model;prevent;programs;Prostate;Proteins;Quality of life;recruit;Research;Research Personnel;Resistance;response;RNA;Role;Signal Induction;Signal Transduction;Solid Neoplasm;Stomach;success;T-Lymphocyte;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;Tissues;Transcript;Transcriptional Activation;transcriptomics;treatment response;treatment strategy;tumor;Tumor Biology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Subtype;Tumor-Derived;tumor-immune system interactions;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Harnessing the nervous system to overcome resistance to immunotherapy in oral cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: Project Narrative Cervical cancer incidence has increased among Puerto Rican women in recent years. This study will evaluate the impact of patient reminders, patient navigators, and self-collection on cervical cancer screening and follow- up care among Puerto Rican women. To inform the future broad-scale implementation of the effective approaches, we will also identify factors influencing the use of these strategies and determine their cost- effectiveness and budget impact.

PI_NAMEs: DESHMUKH, ASHISH A.;ORTIZ, ANA PATRICIA (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Age;arm;budget impact;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;cohort;Collection;Colposcopy;Communities;cost effective;cost effectiveness;Diagnosis;Diagnostic Reagent Kits;Disasters;Disparity;Distant;Early Diagnosis;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Eligibility Determination;Evaluation;Event;follow-up;Future;Goals;Government;Home;home test;Human Papillomavirus;Hybrids;Hysterectomy;implementation evaluation;implementation outcomes;improved;Incidence;Individual;interest;Intervention;Intervention Studies;Interview;Island;Knowledge;Low income;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;mathematical model;Medicaid;Medicare;Minority Women;models and simulation;Morbid Obesity;mortality;multi-component intervention;multidisciplinary;Natural History;Obesity;Pap smear;patient navigation;patient navigator;Patients;Population;Population Study;premalignant;President's Cancer Panel;Provider;Puerto Rican;Puerto Rico;Randomized, Controlled Trials;Recovery;Sampling;screening;screening participation;Screening Result;secondary analysis;secondary outcome;self testing;Site;Squamous intraepithelial lesion;success;Testing;Transportation;Treatment outcome;trend;United States;uptake;Visit;Woman;women's outcomes;women's treatment;Work;World Health Organization

PROJECT_TITLE: The effectiveness, cost-effectiveness, and budget impact of interventions to improve the delivery of cervical cancer screening in Puerto Rico.

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Harnessing a patient’s immune system to attack melanoma is remarkably successful. In one promising approach T cells are harvested directly from the patient’s tumor, expanded to very high numbers in the laboratory where they can be rejuvenated, and returned to the patient to fight their cancer. As this is only effective in approximately half of patients with advanced disease, here we develop a novel, safe and efficient method to further boost these tumor-reactive T cells by mRNA reprogramming.

PI_NAMEs: HURWITZ, MICHAEL E;KATZ, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acclimatization;Address;Adoptive Immunotherapy;advanced disease;Antitumor Response;Apoptotic;Back;Cell Differentiation process;cell mediated immune response;Cell Reprogramming;Cell Therapy;Cells;Clinical;Clinical Trials;cytokine;Cytolysis;Data;design;Dose;effector T cell;efficacy evaluation;Electroporation;Environment;experimental study;fighting;Fishes;Fluorescent in Situ Hybridization;Frequencies;Future;gene therapy;Generations;Genes;Goals;Harvest;humanized mouse;Image;Immune checkpoint inhibitor;Immune system;Immunologic Factors;Immunotherapy;improved;In complete remission;In Vitro;Individual;Infrastructure;Infusion procedures;Insertional Mutagenesis;instrument;Interleukin-2;Knowledge;Laboratories;Lesion;life span;Ligands;long term memory;Lymphocyte;Lymphocyte Activation;lymphocyte product;Malignant - descriptor;Malignant Neoplasms;manufacture;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;Memory;Messenger RNA;Metastatic Melanoma;Methods;mouse model;mRNA Expression;multidisciplinary;neoplastic cell;novel;objective response rate;Outcome;OX40;Pathway interactions;patient derived xenograft model;patient population;Patients;Phenotype;Population;Population Heterogeneity;Positioning Attribute;pre-clinical;Production;programs;Property;Proteins;Protocols documentation;Rejuvenation;Research;response;RNA;Safety;Sampling;single cell analysis;single-cell RNA sequencing;success;System;T cell receptor repertoire sequencing;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapy Clinical Trials;Time;TNFSF4 gene;transcriptomics;Transfection;Treatment Efficacy;tumor;Tumor Antigens;Tumor Expansion;tumor growth;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Variant;Work

PROJECT_TITLE: Enhancing Melanoma TIL Efficacy with Multifactor mRNA-Mediated T Cell Reprogramming


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Although diverse perspectives and expertise are needed to solve current, complex health problems, individuals from underrepresented racial/ethnic groups, disadvantaged backgrounds, and individuals with disabilities are significantly less likely to end up in science careers. Evidence suggests that targeted undergraduate research programs substantially improve persistence and conceptualization of a future career in research. This proposal continues an intensive summer research experience in the study of alcohol and related behavioral health outcomes for undergraduates from underrepresented groups in order to develop a pipeline for increasing diversity in biomedical and behavioral research.

PI_NAMEs: ADKINS, AMY ELIZABETH (contact);DICK, DANIELLE M

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Active Learning;addiction;Address;Advertising;Alcohol consumption;alcohol research;Alcohols;behavioral health;Behavioral Research;biobehavior;Biomedical Research;career;career development;Case Study;Complement;Complex;data management;Data Set;design;Development;disability;Disabled Persons;disadvantaged background;Educational workshop;Enrollment;Ethnic Population;experience;Faculty;faculty mentor;Fostering;Funding;Future;Genetic;Goals;graduate school;Graduation Rates;Health;improved;Individual;innovation;Interdisciplinary Study;Internships;Leadership;lectures;matriculation;Mentors;Mentorship;Modeling;next generation;Outcome;peer;peer coaching;Population;Positioning Attribute;posters;programs;Public Health;racial population;recruit;Registries;Research;research faculty;Research Methodology;Research Personnel;Research Training;responsible research conduct;Science;Secure;Site;skills;statistics;Structure;student participation;Students;substance use;success;summer program;summer research;Training;Translational Research;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;Virginia

PROJECT_TITLE: Guided Research Experiences and Applied Training (GREAT) in Alcohol Studies

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH MH134119 grant. The proposed combined molecular and cellular studies are within the scope of the parent grant. Our proposed study promises to contribute the overall understanding of the molecular mechanisms underlying the CNS adrenergic regulation of learning and memory.

PI_NAMEs: XIANG, YANG K (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adenylate Cyclase;Administrative Supplement;Adrenergic Agents;Arrestins;Attenuated;Biochemical;career;career development;Cell Nucleus;Central Nervous System Agents;Cyclic AMP;disadvantaged background;drug development;Ensure;Excision;experience;Fostering;G protein coupled receptor kinase;Gene Expression;Goals;Grant;Health;Learning;Memory;Mentors;Molecular;Molecular Probes;Nuclear;parent grant;pharmacologic;phosphoric diester hydrolase;Regulation;Request for Applications;Research;Role;Signal Transduction;Source;Testing;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Phosphodiesterases govern nuclear cAMP signaling for gene expression

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: Newark

ORG_DEPT: DENTISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Vital pulp treatment (VPT) is a minimally-invasive procedure carried out to conservatively manage deep caries, by controlling pulpitis and promoting repair, which preserves pulpal vitality. This proposal will determine the novel mechanisms of MMP13 in cases of advanced pulpitis as well as tertiary dentin formation. The knowledge leads to create novel techniques to therapeutically target biological processes in the damaged pulp.

PI_NAMEs: SHIMIZU, EMI  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acute;Address;Affect;AXIN2 gene;Back;Bacteria;Biological Process;Calcium;CCL2 gene;Cell Separation;Cells;Coculture Techniques;collagenase;collagenase 3;Collection;Complex;Crowns;cytokine;Data;Dental caries;Dental Pulp;Dentin;Dentin Formation;Dentinogenesis;Deposition;design;Differentiation Antigens;Down-Regulation;Endodontics;experimental study;Exposure to;Fusobacterium nucleatum;Goals;healing;Histology;Human;human tissue;Iatrogenesis;Immune;Immune response;Immunocompromised Host;Immunofluorescence Immunologic;Immunologics;in vivo;Incisor;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;Interferon Type II;Interleukin-1 beta;JUN gene;Knockout Mice;Knowledge;Link;LoxP-flanked allele;Macrophage;MAPK8 gene;Matrix Metalloproteinases;Mediator;mineralization;minimally invasive;MMP8 gene;Modeling;Molar tooth;Molecular;monocyte;Mus;Myeloid Cells;nestin protein;new therapeutic target;novel;novel strategies;novel therapeutics;Nude Mice;Odontoblasts;Outcome;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Play;Porphyromonas gingivalis;preservation;Preservation Technique;Procedures;Process;Publishing;Pulpitis;Quantitative Reverse Transcriptase PCR;Recombinants;regenerative;regenerative approach;Regenerative capacity;repaired;reparative process;response;Role;scaffold;seal;Silicates;Small Interfering RNA;sound;Tamoxifen;Techniques;Testing;therapeutic target;Tissue Model;Tissues;TNF gene;Tooth Injuries;Tooth structure;transcription factor;transcriptome sequencing;Translating;Trauma;Traumatic injury;WNT Signaling Pathway;wound healing

PROJECT_TITLE: The novel functions of matrix metalloproteinase 13 supporting dentin-pulp reparative processes

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative This project has the potential to identify, for the first time, a screening strategy for earlier detection of HPV-related oropharynx cancer in people living with HIV and without HIV, and to outline a screening algorithm for HPV-OPC that could be tested in a future clinical trial to determine efficacy.

PI_NAMEs: D'SOUZA, GYPSYAMBER ;FAKHRY, CAROLE  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Age;Algorithms;Anogenital cancer;Anogenital Human Papilloma Virus Infection;Antibodies;antibody detection;Biological Markers;biomarker identification;Blood;cancer diagnosis;Characteristics;Chronic;Clinical Trials;co-infection;cohort;comorbidity;Complement;cost;Detection;Disease;DNA;Early Diagnosis;efficacy evaluation;examination questions;financial toxicity;follow-up;Future;Gender;HIV;HPV oropharyngeal cancer;HPV screening;Human Papillomavirus;Human papillomavirus 16;Immune response;Immune system;Immunologics;Impairment;improved;Incidence;Individual;Infection;Knowledge;Learning;Malignant neoplasm of anus;Malignant Neoplasms;malignant oropharynx neoplasm;Medical;Mental Depression;Natural History;Oral;oral HPV;Oropharyngeal;Participant;Performance;Persons;Plasma;Population;Populations at Risk;Predictive Factor;Prevention strategy;prospective;Proteins;research clinical testing;Research Design;Risk;Risk Estimate;Risk Factors;Role;Running;Sampling;screening;Secondary Prevention;Secondary to;seroconversion;seropositive;specific biomarkers;Specificity;Suicide;Survivors;Testing;Time;Triage;tumor;tv watching;United States;Vaccines

PROJECT_TITLE: Earlier detection of HPV-related oropharynx cancer in people living with and without HIV


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: Princeton

ORG_DEPT: BIOLOGY

ORG_NAME: PRINCETON UNIVERSITY

PHR: All humans and other mammals acquire their gut bacterial communities throughout life from a variety of sources, including family, social contacts, and the external environment. Despite the significance for public health of transmission of gut bacteria, we do not understand the modes by which individual members of the gut microbiota are transmitted, and the genes that determine these transmission modes have not been discovered. The proposed work will combine methods from microbiology, animal experiments, and functional genomics to discover the transmission modes of the mouse gut microbiota and uncover the underlying genetics of bacterial transmission traits.

PI_NAMEs: MOELLER, ANDREW  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Animal Experiments;Bacteria;bacterial community;bacterial genetics;Bacterial Genome;base;Birth;Communities;Complement;Development;enteric pathogen;Environment;Evolution;Family;functional genomics;Generations;Genes;Genetic;Genetic Materials;genomic tools;Germ-Free;Gnotobiotic;gut bacteria;gut microbiota;Horizontal Disease Transmission;Human;Immune system;Individual;Inherited;innovation;insight;Knowledge;Life;Mammals;member;Metabolic;metagenome;Methods;Microbiology;Mothers;Mus;Neurosecretory Systems;novel strategies;Phenotype;Population;Public Health;Shapes;social contact;Social Interaction;Source;Symbiosis;System;trait;transmission process;transposon sequencing;Work

PROJECT_TITLE: Uncovering the modes and genetics of gut bacterial transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE An estimated 3.9 million fractures occur in the US with an annual economic burden of $116.9 billion in combined medical expenses and work loss. Management of pain arising from orthopedic fractures remains a challenge, as common analgesic medications either interfere with healing or possess potential for addiction. Completion of this proposal will establish a new therapeutic strategy for the care of pain due to orthopedic surgery and fractures.

PI_NAMEs: VARGHESE, SHYNI  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Acceleration;Acids;Acute Pain;addiction liability;Address;Adenosine;Adenosine A1 Receptor;Affect;Afferent Neurons;Agonist;Analgesics;Animals;antagonist;Appearance;Attenuated;Behavior;behavior test;Biocompatible Materials;Bone callus;bone fracture repair;Bone Injury;Brain-Derived Neurotrophic Factor;Buprenorphine;Caring;Central Nervous System;chronic pain;Clinical;conditional knockout;crosslink;Cyclic AMP;Data;Dependence;Development;Dinoprostone;Dissociation;Dose;Economic Burden;Environment;Esthesia;experimental study;extracellular;Facial Expression;Fracture;gait examination;Gel;Goals;Harvest;healing;Hyaluronic Acid;improved;In Vitro;in vivo;Injectable;Injury;Ion Channel;knock-down;Light;Locomotion;Matrix Metalloproteinases;Mechanics;Mediating;Medical Care Costs;Membrane Potentials;Microfluidic Microchips;Microfluidics;Mus;Nerve;neurite growth;Neurons;Neuropeptides;neurotrophic factor;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel therapeutic intervention;novel therapeutics;Opioid;Orthopedic Surgery;Orthopedics;Osteogenesis;Pain;Pain management;pain reduction;pain relief;pain sensitivity;Peripheral;Peripheral Nerves;Pharmaceutical Preparations;Prevalence;Production;Purinergic P1 Receptors;receptor;receptor expression;Receptor Signaling;Regulation;Role;scaffold;Sensory Receptors;Series;side effect;Signal Transduction;Site;skeletal;skeletal tissue;Small Interfering RNA;small molecule;Stains;Stimulus;success;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;tibia;Tibial Fractures;Tissues;transcriptome sequencing;transcriptomics;Trauma;TRPV1 gene;Weight-Bearing state;Work

PROJECT_TITLE: Modulation of local adenosine signaling to attenuate fracture pain


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Genetic defects in the cohesin complex member Stag2 are recurrently mutated in various human cancers and lead to disruption of tissue-specific gene expression through DNA looping. Using cutting-edge epigenomic techniques, primary patient samples, and a reversible in vivo Stag2 mouse, we will map Stag2-specific chromatin looping in hematopoietic stem and progenitor cells and functionally assess their contribution to the lineage fate and self-renewal. Using these techniques in combination with sequential mutagenesis of the AML driver mutations NPM1c and FLT3ITD, we will determine the effects of altered chromatin structure on leukemogenesis, the effects on therapeutic response, and the requirement of Stag2 for leukemia maintenance.

PI_NAMEs: VINY, AARON D (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Alleles;biobank;Biological Assay;Bone Marrow;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Loop;Chromatin Structure;cohesin;Complex;Dependence;driver mutation;Enhancers;Epigenetic Process;epigenomics;Event;FLT3 gene;FLT3 inhibition;Gene Expression;Genetic;Genetic Transcription;Hematopoietic;Hematopoietic stem cells;Hi-C;hip replacement arthroplasty;Human;In Vitro;in vivo;leukemia;leukemogenesis;Maintenance;Malignant Neoplasms;Maps;member;Menin;Modeling;molecular pathology;multiple omics;Mus;Mutagenesis;mutant;Mutate;Mutation;new therapeutic target;novel;Output;Patients;Phenocopy;Phenotype;Population;prevent;progenitor;recombinase;Recurrence;Regimen;restoration;Role;Sampling;Secondary acute myeloid leukemia;self-renewal;stem;stem cell population;stem cell self renewal;System;targeted treatment;Techniques;Therapeutic;Tissue-Specific Gene Expression;Transcriptional Regulation;transcriptome sequencing;treatment response;Validation

PROJECT_TITLE: The role of the cohesin complex in hematopoietic transformation and leukemia maintenance

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE While the human body is composed of ~200 different cell types and chronic diseases stem from dysfunction of multiple cells types in specific organs, most human environmental studies have overlooked such complexity. By capturing cell type-specific signals in easily obtainable biospecimens (i.e., standard blood draw) I propose to identify early biological responses to environmental exposures that are predictive of future health-related conditions, specifically of the effects of air pollution on accelerated brain aging—a primary focus of my laboratory. Due to the central roles that extracellular vesicles have in aging and chronic disease, this work will provide a model that can be applied to many other types of exposures and various chronic diseases.

PI_NAMEs: BACCARELLI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;Age;age related;age-related disease;Aging;aging brain;Air;Air Pollution;Award;Binding;Biological;Biological Markers;Biology;Blood;Blood Circulation;Blood specimen;Brain;brain health;bronchial epithelium;Cell Culture Techniques;cell type;Cells;Chronic Disease;Clinical;Clinical Data;Cognitive aging;cognitive function;Cohort Studies;Communication;Data;Data Science;Dementia;Dependence;Deterioration;Early identification;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;extracellular vesicles;flexibility;follow-up;Functional disorder;Funding;Future;Health;Human;Human body;Impaired cognition;In Vitro;Influentials;innovation;interest;Laboratories;Lead;Leadership;Life;Lung;Mediating;Membrane;Methods;MicroRNAs;Modeling;Molecular;nanosized;Nerve Degeneration;novel;Organ;Organoids;Outcome;Particulate;Pattern;Pollution;pre-clinical;prevent;Process;programs;Public Health;Publications;Research Personnel;response;Role;Route;Seminal;Series;Signal Transduction;Source;stem;Surface;System;Techniques;three dimensional cell culture;Time;tool;United States National Institutes of Health;vesicular release;Vision;Work

PROJECT_TITLE: Extracellular vesicles in Environmental Epidemiology Studies of Aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE During development, genetic patterning instructs tissues to form complex shapes that are crucial for proper function. Using whole-organ live imaging and approaches from physics, this study will analyze how gene expression patterns and cell-scale chirality govern tissue-scale mechanical forces to sculpt visceral organs.

PI_NAMEs: MITCHELL, NOAH PRENTICE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Ablation;Atlases;Biological Models;Biology;Calcium;cell behavior;Cell Shape;Cells;clinical application;Communities;Complex;computer framework;computerized tools;Congenital Abnormality;constriction;Cytoskeleton;Development;Developmental Biology;Doctor of Philosophy;driving behavior;driving force;Drosophila genus;Elasticity;Endoderm;Ensure;gene conservation;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Health;Heart;heart defect;Homeobox Genes;Human;Image;imaging modality;in silico;in vivo;Lasers;Learning;Left;Light;Link;malformation;Maps;Measures;mechanical force;Mechanical Stress;Mechanics;Mediating;Microscopy;Midgut;Modeling;Molecular Biology;Morbidity - disease rate;Morphogenesis;mortality;Muscle;mutant;novel;optogenetics;Organ;Organ Model;Pattern;Phase;physical model;Physics;Physiologic pulse;Postdoctoral Fellow;Process;programs;Regulator Genes;Research;Resolution;Role;Shapes;Signal Transduction;spatiotemporal;Structure;Techniques;Testing;Tissue imaging;Tissues;Training;Translating;Tube;Visceral;Visualization;Work

PROJECT_TITLE: Decoding the mechanical interactions between tissue layers sculpting organ shape

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The mission of the Harvard/MIT MD-PhD Program is to “train the next-generation of premier and diverse physician- scientist leaders” who embody the dual-calling to make a difference today by touching the life of a patient in need and make a difference tomorrow by achieving scientific breakthroughs that will change our world. By harnessing the educational, clinical, and scientific resources of Harvard Medical School, Harvard University, the Massachusetts Institute of Technology, and its world-class hospitals and affiliated institutes, we aim to provide our students with unparalleled depth and breadth of clinical and research opportunities supported by a profoundly caring and invested community of student colleagues, faculty mentors, and program staff. Our dynamic training program is based on a series of academic and integrative objectives, girded by principles of rigor, integrity, responsibility, self-evaluation, inclusivity, diversity, and empathy, with the ultimate goal of contributing to a much-needed, multidisciplinary MD-PhD workforce to serve the critical health care and biomedical technology needs of the United States and beyond.

PI_NAMEs: JONES, DAVID SHUMWAY;LEES, JACQUELINE A.;REID, ANDREA E;WALENSKY, LOREN DAVID (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Good quality sleep is essential for the beneficial and restorative effects of sleep, while sleep disturbances negatively impact our mental and physical health. The proposed study will reveal how the neural dynamics and functional connectivity of preoptic neurons with stress-regulatory noradrenergic neurons in the locus coeruleus and corticotropin-releasing hormone neurons in the paraventricular nucleus regulate the duration and quality of sleep after stress. The results will provide a comprehensive framework enhancing our understanding of the regulation of sleep when disturbed by stress and the benefits of improving sleep in attenuating stress-related cognitive symptoms.

PI_NAMEs: CHUNG, SHINJAE  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Animal Model;Arousal;Attenuated;Axon;Behavior;Cholecystokinin;Cognition;Cognitive;cognitive ability;Cognitive deficits;Corticotropin-Releasing Hormone;Deterioration;Dimensions;Electroencephalography;Exhibits;experimental study;Goals;Human;Hypothalamic structure;Image;Impaired cognition;Impairment;improved;improvement on sleep;insight;locus ceruleus structure;Mediating;Memory impairment;Mental Depression;Mental disorders;Mental Health;microendoscope;Mus;Nature;neural;neural circuit;Neurobehavioral Manifestations;Neurons;non rapid eye movement;noradrenergic;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;object recognition;Optics;optogenetics;paraventricular nucleus;patch clamp;Pathway interactions;Patients;Periodicity;Personal Satisfaction;physical conditioning;Physiological;Preoptic Areas;presynaptic;Psychosocial Stress;REM Sleep;Risk;Role;Sleep;sleep abnormalities;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep quantity;sleep regulation;Sleeplessness;social defeat;Stress;stress symptom;Therapeutic;Wakefulness

PROJECT_TITLE: Neural basis underlying the impact of stress on sleep

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Estrogen;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The mechanisms by autism spectrum disorder (ASD)-linked genes cause sex-specific differences in behavior and brain function are relatively unknown. We have discovered a female-specific dysfunction of neocortical circuits and sensory processing in mouse models of ASD caused deletion of Pten. The proposed work will determine the sex-specific brain mechanisms, focusing on metabotropic glutamate and Estrogen receptor α signaling, to understanding the interaction of sex and a high confidence ASD risk gene in regulation of brain function and sensory processing.

PI_NAMEs: HUBER, KIMBERLY M. (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Adolescent;Adult;Affect;antagonist;autism spectrum disorder;Behavior;Behavioral;Brain;Cell Size;chromosome 10 loss;Complex;Data;Dendrites;Development;Electroencephalography;ESR1 gene;Estrogens;Estrus;Excitatory Synapse;experimental study;Female;Functional disorder;Genes;Genetic;genetic manipulation;Germ Lines;Grant;hippocampal pyramidal neuron;human disease;Immunohistochemistry;in vivo;Ion Channel;Knockout Mice;Knowledge;Link;loss of function;male;Mediating;metabotropic glutamate receptor 5;Metabotropic Glutamate Receptors;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;neocortical;neuronal cell body;Neurons;Pathway interactions;pharmacologic;Phase;Phenotype;Property;Protein Biosynthesis;protein expression;Proteins;PTEN gene;Regulation;Rest;Ribosomes;risk variant;Role;Seizures;Sensory;sensory cortex;sensory stimulus;sex;Sex Differences;Sex Differentiation;sexual role;Signal Pathway;Signal Transduction;Social Behavior;Synapses;Synaptic Transmission;Testing;Transcript;Translations;Work

PROJECT_TITLE: Sex-specific mechanisms of cortical circuit dysfunction in a mouse ASD model


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Telehealth;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We propose to leverage widespread smartphone use in urban Ghana together with accessible technology adapted to the Ghanaian setting to overcome barriers to home blood pressure monitoring in pregnancy. The proposed study will adapt and measure feasibility and acceptability (R21 Phase) and evaluate adherence and clinical response (R33 Phase) of a Bluetooth blood pressure monitor and smartphone app-enhanced home blood pressure monitoring intervention among pregnant women in Ghana. Implementing home blood pressure monitoring in a low-and-middle-income country setting will provide a critical step toward frequent assessment of blood pressures, earlier diagnosis of hypertensive disorders of pregnancy, and prevention of serious maternal morbidity and mortality.

PI_NAMEs: LAWRENCE, EMMA RACHEL (contact);OPPONG, SAMUEL ANTWI

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Age;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;Bluetooth;Caring;Cellular Phone;Client satisfaction;Clinical;clinical risk;cognitive interview;Consensus;Country;Data;Discipline of obstetrics;Drops;Early Diagnosis;Eclampsia;Enrollment;Focus Groups;forgetting;Frequencies;Gestational Age;Ghana;Group Interviews;Gynecologist;Healthcare Systems;Home;Home Blood Pressure Monitoring;Hospitals;Hour;Hypertension;hypertensive factor;Income;Intervention;Language;literacy;low and middle-income countries;low health literacy;maternal morbidity;Maternal Mortality;mathematical ability;Measures;mhealth interventions;Midwife;Monitor;Morbidity - disease rate;mortality;Netherlands;Notification;novel;novel strategies;Nurses;Outcome;Participant;Patients;Phase;phrases;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;pregnancy related death;pregnant;Pregnant Women;Prenatal care;prevent;preventable death;Prevention;Production;programs;Prospective cohort;Protocols documentation;Provider;Recommendation;recruit;response;Safety;Seizures;Site;smartphone application;Stroke;Symptoms;System;Technology;Telephone;Testing;Time;Training;Woman;Work

PROJECT_TITLE: Adapting and evaluating smartphone app-enhanced home blood pressure monitoring among pregnant women in Ghana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (56)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Our project explores the intricate interplay of genomic instability and chromatin dynamics in C9orf72-associated ALS with frontotemporal dementia (C9-ALS/FTD). Through mapping cell-specific patterns of transposable element (TE) mobilization, elucidating the c-JUN/TE/cGAS/STING pathway activation, and investigating therapeutic interventions, we aim to shed light on the pathogenesis of C9-ALS/FTD and unveil potential treatment strategies. Ultimately, our endeavor seeks to unravel the mechanisms of neurodegeneration.

PI_NAMEs: PASINELLI, PIERA ;TRIZZINO, MARCO ;TROTTI, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Apoptosis;ATAC-seq;Atlases;Attenuated;Autophagocytosis;Autopsy;Binding;Brain;brain cell;brain tissue;C-terminal;C9ALS;C9ORF72;Cell Death;cell injury;Cell Line;Cell model;cell type;Cells;Cerebrum;Chromatin;Chromatin Remodeling Factor;Complex;Cytoplasm;data integration;derepression;Disease;DNA;DNA Transposable Elements;Drosophila genus;efficacy evaluation;familial Alzheimer disease;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genomic Instability;Genotype;holistic approach;Human;human tissue;Hybrids;Hyperactivity;Impairment;In Vitro;induced pluripotent stem cell;Inflammation;inhibitor;Innate Immune Response;insight;Investigation;JUN gene;Maps;Modeling;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neurotoxicity;novel;Organelles;Organoids;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Play;Process;Proteins;recruit;Relaxation;Reporting;Repression;Reverse Transcriptase Inhibitors;RNA;Role;single cell genomics;small molecule inhibitor;Stimulator of Interferon Genes;Therapeutic;Therapeutic Intervention;Time;Tissues;Transcription Coactivator;Transcription Factor AP-1;Treatment Efficacy;treatment strategy;Up-Regulation;wasting;Work

PROJECT_TITLE: Role of the TE-cGAS-STING pathway in C9orf72-ALS/FTD pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Latine sexual and gender minority (SGM) adolescents and young adults (AYA) have been shown to have worse mental, physical, and sexual health outcomes than non-SGM AYA, but research is lacking on the experiences of Latine SGM AYA who reside in rural settings who may have increased concerns around confidentiality and stigma in their communities. This research supplement adds additional quantitative and qualitative data collection with SGM AYA to an ongoing study that has been designed to examine the effects of multiple social determinants on sexual health in Latine AYA in an agricultural setting in California. The proposed research will fill a critical gap in literature regarding disparities in sexual health outcomes for Latine SGM AYA residing in rural areas and by deepening our understanding of structural factors that limit or promote sexual health in this population to ultimately increase Latine SGM AYA’s well-being and positive sexual health.

PI_NAMEs: MINNIS, ALEXANDRA M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 21 year old;Address;Adolescent;Adolescent and Young Adult;adult of color;Affect;Age;agricultural community;Agriculture;Area;Biological Testing;California;Caring;cohort;Cohort Studies;Communities;community engaged approach;community organizations;community partners;condoms;County;Data;Data Collection;dating violence;Decision Making;design;Development;Disparity;early adolescence;early sex initiation;emerging adult;emerging adulthood;Enrollment;Epidemic;experience;follow-up;Gender;gender minority group;gender minority youth;Geographic Locations;Goals;Health;Health Services;Homophobia;Inequity;Infection;infection rate;Infrastructure;interest;Intersex;Interview;Latinx;Lead;Lesbian Gay Bisexual Transgender Queer;Literature;Mental disorders;Mental Health;neglect;Outcome;Parents;Participant;perceived discrimination;Personal Satisfaction;Phase;physical conditioning;Population;Positioning Attribute;Pregnancy;prevent;programs;Public Health;Questionnaires;racism;recruit;Research;Rural;rural area;rural setting;Sampling;satisfaction;school district;Sexual and Gender Minorities;Sexual Health;sexual minority youth;sexual relationship;Sexuality;Sexually Transmitted Diseases;social;social culture;social determinants;social factors;social influence;social stigma;structural determinants;substance use;therapy development;Time;transition to adulthood;United States;Violence;young adult;Youth

PROJECT_TITLE: Social influences on sexual health among Latinx adolescents and emerging adults who identify as LGBTQ+ in an agricultural community

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Bioengineering;Lung;Nanotechnology

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: The proposed studies will elucidate the contribution of specific engineered nanomaterial properties that determine in vitro and in vivo toxicity, as well as provide mechanistic information to help develop therapeutic interventions to block their inflammation when inhaled. These results will also be used to help develop treatments to block inflammation caused by various particles including silicates. Finally, this information will be used to develop safer materials to protect workers and end users.

PI_NAMEs: HOLIAN, ANDRIJ  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Aerosols;Affect;Alveolar Macrophages;amphiphilicity;Animal Model;Applied Research;Asbestos;bafilomycin A;Biological;Biological Models;CASP1 gene;Cell Membrane Permeability;Cell Physiology;Cells;Characteristics;Charge;Chemistry;Cholesterol;commercial application;cytokine;cytotoxicity;design;Development;Disease;Dust;Engineering;Event;exposed human population;Exposure to;fundamental research;Goals;granite;hazard;Health;IL18 gene;Immune;In Vitro;in vivo;Industrialization;Inflammasome;Inflammation;Inflammatory;Inhalation;Injury;interest;Interleukin-1 beta;Knockout Mice;Knowledge;large-conductance calcium-activated potassium channels;Libraries;Lung Diseases;lysosome membrane;Lysosomes;Macrophage;Mediating;Membrane;metal oxide;Mitochondria;Modeling;nanoengineering;nanomaterials;Nanosphere;Nanotechnology;nanotoxicology;novel therapeutics;Occupational;Outcome;particle;particle exposure;Particle Size;Pathology;Pathway interactions;paxilline;Peptide Hydrolases;Phagolysosome;Phagosomes;Pharmaceutical Preparations;Phenotype;Preparation;prevent;Process;Property;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonary Pathology;Research;Resolution;response;Role;Signal Transduction;Silicates;Silicon Dioxide;Surface;Surface Properties;Systemic disease;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;titanium dioxide;Toxic effect;Uncertainty;Vesicle;water solubility;Wettability

PROJECT_TITLE: Role of particle surface functionalization in inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: WISTAR INSTITUTE

PHR: PROJECT NARRATIVE Glioblastoma is an incurable primary malignant brain cancer and is characterized by a profound immunosuppressive microenvironment which renders this cancer highly resistant to immunotherapy. The proposed studies will exert a profound effect in the field by dissecting targetable metabolic and molecular mechanisms regulating the function of tumor associated macrophages, which are instrumental for the maintenance of immunosuppressive state of glioblastoma. This mechanistic understanding will be critical to provide our clinical partners with novel therapeutic approaches to overcome immunosuppression and to enhance the efficacy of immunotherapy in GBM patients, which will be tested in subsequent clinical trials.

PI_NAMEs: VEGLIA, FILIPPO  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;Automobile Driving;Avidity;Binding;CAR T cell therapy;Cell Physiology;Cells;chimeric antigen receptor T cells;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Trials;Consumption;Data;Development;effective intervention;Endoplasmic Reticulum;endoplasmic reticulum stress;Epigenetic Process;Exhibits;Exposure to;gene induction;Genes;Genetic Transcription;Glioblastoma;Glioma;Glucose;glucose metabolism;Glycolysis;Goals;Histone Acetylation;Histones;Human;Hypoxia;Immune;Immunosuppression;immunosuppressive macrophages;Immunotherapy;improved;In Vitro;in vivo;Infiltration;innovation;Isotopes;Label;Link;Lysine;Macrophage;Maintenance;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediator;Metabolic;metabolomics;Microglia;Modification;Molecular;monocyte;multiple omics;Myeloid Cells;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Outcome;Patients;Phosphotransferases;Play;Production;programs;promoter;Regulation;Resistance;resistance mechanism;Role;sensor;Signal Transduction;SLC2A1 gene;Specimen;stressor;System;T cell therapy;Testing;Therapeutic;therapeutic evaluation;Tissues;Treatment Efficacy;tumor;Tumor Immunity;Tumor-associated macrophages;tumor-immune system interactions;Work

PROJECT_TITLE: Metabolic and molecular regulation of myeloid cell functions in brain cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: NARRATIVE This application is for a diversity supplement for Dr. Kayla Fike on the NIA funded DNA methylation in context: Racial inequities in social adversity and vulnerability to the health impact of air pollution (R01AG074887; PI Hicken) whose overall aims are to identify underlying DNA methylation mechanisms linking neighborhood segregation and ambient and industrial air pollution and social adversity to measures of healthy aging.

PI_NAMEs: HICKEN, MARGARET TAKAKO (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Adult;aging related;Air Pollution;Biological;Black race;Cardiovascular Diseases;Chemicals;Chronic;Chronic Disease;Diabetes Mellitus;Disease;DNA Methylation;early onset;effective intervention;Environmental Epidemiology;Environmental Exposure;Environmental Science;Epigenetic Process;Etiology;experience;Exposure to;Funding;Health;health inequalities;healthy aging;Hypertension;Impaired cognition;Industrialization;Inequity;Intervention;Knowledge;Link;Literature;Measures;methylation pattern;Neighborhoods;Outcome;Pathway interactions;Policies;Pollution;Race;racial determinant;racial disparity;Racial Segregation;Research;Resources;Risk;Role;segregation;Site;social;social adversity;Social Environment;social epidemiology;Social Sciences;social vulnerability;stressor

PROJECT_TITLE: DNA methylation in context: Racial inequities in social adversity and vulnerability to the health impact of air pollution - Diversity Supplement (Fike)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Social Determinants of Health;Transplantation

ORG_CITY: KANSAS CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE We propose a novel healthcare-community partnership between medical clinics and food banks, called Nutrition OUtReach In Systems of Healthcare (NOURISH), to address food insecurity (lack of consistent access to food) by directly delivering bags of food to patients in clinic. We will evaluate NOURISH in a multicenter randomized controlled trial in food insecure patients with hematologic malignancies receiving transplant and cellular therapy (TCT). We focus on this patient population because of their significant need – most relocate to a cancer center for their care, away from their home support network, and struggle with malnutrition, depression, and other adverse outcomes – and potential for long-term sustainability: bundled payments for TCT give health systems an incentive to support NOURISH and similar collaborations with food banks if we can demonstrate improved outcomes and lower healthcare costs.

PI_NAMEs: ARTHUR, ANNA E;SUNG, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Accounting;Address;Adoption;adverse outcome;Affect;American;Anorexia;Appointment;bundled payment;Cancer Center;care outcomes;Caregivers;Caring;Cell Therapy;Client satisfaction;Clinic;Clinical;Collaborations;Communities;community partnership;Complex;cost;cost outcomes;Cost Savings;Data;delivered meals;dietary;Dietitian;Economics;experience;Financial Support;Food;Food Assistance Programs;food insecurity;Funding;Health Care Costs;health care disparity;health care service organization;health care service utilization;Health Personnel;Health system;Healthcare;healthcare community;Healthcare Systems;Hematologic Neoplasms;high risk;Home;Hospitalization;Household;immune-related adverse events;Improve Access;improved;improved outcome;Incentives;Infection;Institution;intervention cost;Intravenous;Joints;Kansas;Length of Stay;Letters;Life;Link;Logistics;Malignant Neoplasms;Malnutrition;Medical;Medicine;member;Memorial Sloan-Kettering Cancer Center;Mental Depression;Mental Health;microbiome;Modeling;mortality;Multicenter Studies;Nausea;novel;Nurses;nutrition;Nutritional;Oncology;Outcome;outreach;patient population;Patient-Focused Outcomes;Patients;Pediatric Hematology;Persons;Pharmacy facility;Physicians;poor health outcome;Population;preference;prevent;primary endpoint;Procedures;programs;Randomized, Controlled Trials;Recommendation;Resources;side effect;social health determinants;social stigma;Social Workers;Source;success;support network;therapy outcome;Time;Total Parenteral Nutrition;transplantation therapy;Universities;Work

PROJECT_TITLE: Addressing Food Insecurity in Transplant and Cellular Therapy Patients with Healthcare-Community Partnerships

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (07)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Research suggests that synaptic activity and signaling can regulate social behavior that is essential to survive for many species. However, the links between synaptic regulation and social behavior are not completely understood. As δ-catenin is involved in the regulation of synaptic function and linked to autism, the proposed work will investigate the δ-catenin-mediated link of synaptic, cellular, and neural substrates to social behavior.

PI_NAMEs: KIM, SEONIL  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;AMPA Receptors;Animals;autism spectrum disorder;Cells;Data;delta-catenin;Disease;Ensure;Etiology;Excitatory Synapse;Family;Genes;Glutamates;Glycine;hippocampal pyramidal neuron;Human;Impairment;Interneurons;Knockout Mice;Link;Medial;Mediating;mouse model;Mus;Mutant Strains Mice;Mutation;neural;Neurons;Parvalbumins;Pathway interactions;Pattern;Periodicity;Persons;postsynaptic;Prefrontal Cortex;Psyche structure;Regulation;Research;Role;Serine;Signal Transduction;social;Social Behavior;Social Controls;social deficits;Social Interaction;Symptoms;Synapses;synaptic function;Work

PROJECT_TITLE: The roles of delta-catenin in social behavior


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Bereaving a drug overdose death is more common than ever before and this special grief is compounded by guilt, shame, stigma, isolation, and adverse substance use and mental health outcomes. In the proposed practice-research partnership, we aim to increase access to peer grief support for those bereaving an overdose death to help improve outcomes and mitigate downstream consequences that impact both the individual and the community.

PI_NAMEs: ATHEY, ALISON ;OSILLA, KAREN CHAN (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: acceptability and feasibility;Accidental Injury;Address;Adult;Affect;Area;Bereavement;Cessation of life;Characteristics;Collaborations;Communities;community organizations;community partners;coping;Data Collection;design;Disease;Drug Modelings;Drug usage;Drug user;effectiveness evaluation;Effectiveness of Interventions;empowerment;evidence base;experience;Face;Family;Family member;family support;Feeling suicidal;Friends;Grief reaction;Guilt;Health;help-seeking behavior;Helping to End Addiction Long-term;Homicide;Hour;improved;improved outcome;Individual;innovation;Intervention;intervention delivery;intervention refinement;Interview;Investigation;Knowledge;Left;Literature;Lived experience;loved ones;Major Depressive Disorder;Measures;Medical Examiners;Mental Depression;Mental Health;Modeling;Monitor;Morbidity - disease rate;mortality;neglect;non-drug;Notification;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;outreach;Overdose;overdose death;overdose risk;Participant;patient engagement;peer;peer support;Personal Satisfaction;Persons;Pharmaceutical Preparations;pilot test;Population;Post-Traumatic Stress Disorders;programs;Public Health;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Resources;response;Risk;Sampling;Science;Shame;social stigma;Speed;substance use;Substance Use Disorder;Suicide;Surveys;Testing;tool;Training;treatment as usual;trial comparing;United States National Institutes of Health

PROJECT_TITLE: Families left behind: Addressing prolonged grief and substance use disorders among people bereaved by drug overdose deaths

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (O1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The internal sensory nervous system maintains bodily homeostasis by monitoring the status of organs and controlling behavior and physiology. Using genetic tools to dissect neural circuits, I will determine the sensory properties and behavioral/physiological role of brainstem efferent pathways, focusing on neural control of appetite. This proposal will build a neuroanatomical and functional roadmap of the viscerosensory neural circuits in the brainstem, providing insights into developing targeted strategies for treating obesity, diabetes, eating disorders, and other diseases.

PI_NAMEs: RAN, CHEN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Anatomy;Animals;Anorexia;Atlases;Behavior;Behavior Control;Behavioral;Brain;Brain region;Brain Stem;Calcium;Cardiovascular Physiology;Cardiovascular system;Categories;Cell Nucleus;cell type;Code;Complex;conditioned place preference;Cues;Data;Desire for food;detection platform;Diabetes Mellitus;Digestive Physiology;Disease;Eating;Eating Disorders;Efferent Pathways;Emetics;Energy Metabolism;experimental study;Feedback;feeding;Feeding behaviors;flyer;Food;gastrointestinal;gastrointestinal system;Gastrointestinal tract structure;Genetic;genetic approach;Goals;Health;Homeostasis;Hormones;Hunger;Hypothalamic structure;Image;imaging platform;in vivo;in vivo calcium imaging;Individual;Inflammatory;Ingestion;insight;Intestines;Irritants;Label;Logic;Manuscripts;Maps;mechanical signal;Mediating;Metabolic;Metabolic Control;Metabolism;Monitor;Motor Neurons;Mus;Nature;Nausea;nerve supply;Nervous System;neural;neural circuit;Neuroanatomy;Neurons;neuroregulation;neurotransmission;novel;Nucleus solitarius;Nutrient;Obesity;optogenetics;Organ;paraventricular nucleus;Pathway interactions;Pattern;Peer Review;Perception;Physiological;Physiology;Play;Population;Postdoctoral Fellow;Process;Property;Research;respiratory;Respiratory physiology;Respiratory System;response;Role;Satiation;Scientist;segregation;Sensory;sensory system;Signal Transduction;Sorting;Specificity;Stimulus;Stomach;System;Taste aversion;Therapeutic;Time;tool;Toxin;transmission process;two-photon;Vagus nerve structure;Viral;virus genetics;Visceral;Visceral pain;Water consumption;Work

PROJECT_TITLE: Deconstructing brainstem circuits for visceral senses

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: GOODRICH, RAYMOND  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Blood;Clinical;Communicable Diseases;Contracts;COVID-19 vaccine;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;manufacture;pathogen;response;Safety;stability testing;Technology;Toxicology;vaccine development;Vaccines

PROJECT_TITLE: To Develop and Manufacture an Inactivated SARS-CoV-2 Vaccine Using Blood Pathogen Reduction Technology


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Biotechnology;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: These projects characterize the potential exposure to and potential health effects of fungal contamination in the built environment.

PROJECT_TERMS: Acoustics;Address;Aerosols;Agreement;air sampling;Aspergillus;Aspergillus fumigatus;B-Lymphocytes;Basidiomycota;Biological Markers;Brain;built environment;Cardiac;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Infiltration;Collaborations;Computers;Cryptococcus;Cryptococcus neoformans;cytokine;Data;Data Set;Development;Environment;exposed human population;Exposure to;fungus;Gene Modified;Genomics;Goals;Growth;Health;Health Hazards;Heart;heart function;human model;IL4 gene;Immune;Immunologics;Impairment;improved;Individual;indoor air;Indoor environment;Infiltration;Inflammatory;Inhalation;Inhalation Exposure;insight;Interleukin-13;Knowledge;Lung;Lung immune response;Lymphoid;Lymphoid Cell;Measures;Messenger RNA;Methodology;microbial;MicroRNAs;Mission;Modeling;Molds;mouse model;Mouse Strains;Mus;Mycotoxins;Myelogenous;National Institute of Environmental Health Sciences;Neurologic;Occupational;particle;Proteomics;Public Health;Pulmonary arterial remodeling;Reagent;Recovery;Reporting;respiratory;response;Role;Stachybotrys;System;systemic toxicity;T-Lymphocyte;Time;Tissues;Toxicology;Yeasts

PROJECT_TITLE: Murine Models of Repeated Fungal Inhalation Exposure


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Women are the fastest growing subgroup of United States Veterans and policy makers are cognizant of the demand on resources for the health and well-being of women Veterans. While some cancers that affect women, such as cervical and breast cancer, have seen a dramatic reduction in mortality due to advances in prevention and early detection, the cure rate for ovarian cancer has not changed in four decades and remains below 40%. The results of this project will lead to a better understanding of the microenvironmental changes that precede ovarian cancer initiation. Such information is necessary to develop strategies for ovarian cancer prevention and early detection, which are urgently needed in clinical practice.

PI_NAMEs: ORSULIC, SANDRA  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Atypia;Bioinformatics;Biological Markers;biomarker development;biomarker identification;BRCA1 gene;BRCA1 Mutation;cancer cell;Cancer Detection;cancer initiation;cancer prevention;Cancerous;CDC2 gene;Cell Cycle;Cell Death;Cell Death Induction;cell injury;Cell Polarity;Cell Proliferation;Cell Separation;Cell Survival;cell transformation;Cells;Characteristics;clinical practice;clinically relevant;Collection;convolutional neural network;curative treatments;Cytoprotection;Data;deep neural network;Development;DNA Damage;DNA Repair;DNA Sequence Alteration;early detection biomarkers;Early Diagnosis;early onset;Environment;Epithelium;Equilibrium;Event;Excision;Follicular Fluid;gene function;Genes;Genetic;genetic risk factor;Genomic Instability;Genotoxic Stress;Germ Lines;Growth Factor;Health Resources;high risk;Histologic;Hormonal Change;Hormones;Human;human induced pluripotent stem cells;Image;image processing;in vivo;induced pluripotent stem cell;inhibitor;Lesion;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Modeling;Molecular;Molecular Analysis;Morphology;mortality;mouse model;Mus;mutant;mutation carrier;neoplastic;Operative Surgical Procedures;Organoids;Outcome;ovarian cancer prevention;Ovarian Serous Adenocarcinoma;Ovary;overexpression;Ovulation;Pathway interactions;Patients;permissiveness;Personal Satisfaction;pharmacologic;Policy Maker;Populations at Risk;Postmenopause;Preclinical Testing;premalignant;prevent;Prevention;Process;Progesterone;Proliferating;PTEN gene;Research;Resources;response;Risk;Risk Reduction;Role;Sampling;screening;Screening for cancer;Secretory Cell;segregation;Signal Transduction;specific biomarkers;Specimen;spheroids;stem cell organoids;Stratification;Stress;Subgroup;survivin;Symptoms;Test Result;Testing;Therapeutic;tool;TP53 gene;transcriptome sequencing;transcriptomics;tumor growth;tumor initiation;Tumor Suppressor Genes;United States;Veterans;Woman

PROJECT_TITLE: Precancer Niche Formation in the Fallopian Tube


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Progressive aging is a major risk factor for developing degenerative retinal diseases, however molecular mechanisms that regulate cellular aging in the retina are poorly understood. This work seeks to use approaches that have been previously applied to studying retinal development and regeneration to uncover gene regulatory networks that control retinal aging and identify putative molecular targets that can induce retinal rejuvenation. This work will produce many broadly applicable datasets that will be both expand our understanding of retinal aging and central nervous system aging more generally. We anticipate that this work will provide great insight into the mechanisms controlling aging and identify potential targets for intervention to slow or reverse retinal aging and thus delay the onset of age-related blinding diseases.

PI_NAMEs: PALAZZO, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acceleration;Acute;adeno-associated viral vector;Age;Age of Onset;age related;age-related disease;Aging;aging clocks;aging gene;aging mechanism;aging process;Automobile Driving;Bioinformatics;biological age;Blindness;cell age;Cell Aging;Cell Physiology;cell type;Cells;Central Nervous System;Cessation of life;Characteristics;Chromatin;Chronology;Data;Data Set;Deceleration;Degenerative Disorder;Development;Disease;DNA Methylation;epigenetic clock;Epigenetic Process;epigenomics;Functional disorder;Gene Expression;gene network;gene regulatory network;Gene Targeting;human old age (65+);Individual;Inflammatory;Injury;insight;Intervention;Intervention Studies;life span;Light;Measures;Methylation;Molecular;Molecular Target;Muller's cell;multiple omics;Mus;N-Methylaspartate;Natural regeneration;neuron regeneration;Neurons;normal aging;Organism;Pathway Analysis;Pattern;Peripheral;Persons;Photoreceptors;prevent;Process;Recovery;Rejuvenation;Repression;Resolution;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;Risk;Risk Factors;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Testing;Therapeutic;tissue degeneration;Tissues;tool;transcription factor;transcriptomics;Vision;Work;Youth

PROJECT_TITLE: Identifying Molecular Mechanisms Regulating Retinal Aging


ORG_CITY: COLUMBIA

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: SC

PHR: Over the past 10 years, we have identified that a specific enzyme system that degrades structural proteins within the heart muscle is upregulated following a heart attack. This study will determine how interruption of this enzyme system by local injection of specifically designed molecules will improve heart structure and function following a heart attack. This study is the first to use these new local target approaches, which will provide specific treatment to the heart but not cause side-effects – a problem with medications that are given by mouth or injection. These studies will directly demonstrate the utility of a new strategy for preventing patients from developing heart failure. These results will set the stage for an entirely new treatment approach for patients suffering from heart failure after a heart attack.

PI_NAMEs: SPINALE, FRANCIS G (contact)

PROJECT_TERMS: Acceleration;Adverse event;Aging;Animals;Attenuated;attenuation;Biological;burden of illness;Catheters;Chemistry;Clinical;Clinical Trials;clinically relevant;controlled release;conventional therapy;Coupled;design;Development;Dose;Drug Delivery Systems;Engineering;Enzyme Inhibition;Enzymes;Event;experience;Extracellular Matrix;Failure;Family suidae;Feasibility Studies;Fibroblasts;Formulation;Funding;Gel;Heart;Heart failure;Heterogeneity;Hyaluronic Acid;Hydrogels;Image;improved;Inhibition of Matrix Metalloproteinases Pathway;Injections;Interruption;interstitial;Laboratories;Left;Left Ventricular Remodeling;Location;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Messenger RNA;Methods;Microdialysis;minimally invasive;Modeling;Myocardial;myocardial infarct sizing;Myocardial Infarction;Myocardium;Natural History;novel;novel therapeutic intervention;Oral cavity;Outcome;Pathway interactions;patient population;Patients;Pattern;Peptide Hydrolases;Peptides;Peptidyl-Dipeptidase A;Performance;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Population;pre-clinical;preclinical efficacy;predict clinical outcome;prevent;Process;prognostic;Protocols documentation;Pump;Regimen;Research;second harmonic;self assembly;Severities;side effect;small molecule;small molecule inhibitor;Specificity;Structural Protein;Structure;System;systemic barrier;targeted delivery;Techniques;Therapeutic;therapeutic target;Time;transdifferentiation;Translating;Ventricular

PROJECT_TITLE: Maladaptive Remodeling in Aging Myocardium


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Infertility;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Many cancer treatments are gonadotoxic and have a high likelihood of subsequent infertility, placing comprehensive fertility care at the forefront of quality care delivery to ensure that adolescent and young adult (AYA) patients are not disproportionately affected by their cancer experience. Understanding the multilevel influences across the cancer care continuum, including patient-, provider-, system-, and policy-level factors, is critical to effectively improve oncofertility care and create optimal long-term outcomes. My dissertation research will use cancer-registry data to characterize the fertility experiences of ethnically diverse AYAs and will qualitatively explore barriers/facilitators to guideline-concordant fertility discussions among cancer care providers, while my postdoctoral research will extend this work to investigate provider implementation and perceived actionability of fertility guidelines and insurer adherence to legislative mandates and barriers to covering fertility preservation through insurer perspectives.

PI_NAMEs: STAL, JULIA  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Affect;Age;American;American Society of Clinical Oncology;Area;Awareness;Biological;cancer care;Cancer Patient;Cancer Survivor;cancer therapy;care delivery;care providers;career;Caring;chemotherapy;Child;Clinical;clinical practice;Clinical Practice Guideline;Community Clinical Oncology Program;Comprehensive Cancer Center;Continuity of Patient Care;cost;Counseling;curative treatments;Data;data registry;Diagnosis;Disparity;Distress;Effectiveness;egg;Ensure;Equity;ethnic diversity;evidence base;Evidence based intervention;experience;Family Planning;Female;Fertility;fertility preservation;Future;Goals;Guidelines;health care service utilization;Health Insurance;Health Policy;Healthcare;Impairment;implementation barriers;implementation intervention;implementation science;improved;Infertility;Influentials;Insurance;Insurance Carriers;Insurance Coverage;Intervention;Intervention Studies;Knowledge;male;Malignant Neoplasms;Medical;Mentors;Minority;Modality;Modification;neoplasm registry;Not Hispanic or Latino;oncofertility;Oncologist;Outcome;Patient Care;Patients;Perception;Phase;Policies;Population;population based;Positioning Attribute;Postdoctoral Fellow;Practice Guidelines;practice setting;preservation;Prevalence;Provider;provider adherence;provider factors;Qualitative Research;Quality of Care;racial diversity;Radiation;Recommendation;Reporting;reproductive;Reproductive Medicine;reproductive outcome;Research;Research Methodology;Research Personnel;Research Priority;Resources;Risk;Sampling;SEER Program;Self Efficacy;Societies;sociodemographics;Specialist;sperm cell;Statutes and Laws;Survivors;System;Training;Translating;United States;uptake;Work

PROJECT_TITLE: Fertility legislation and unmet needs: Exploring intervenable barriers for quality oncofertility care among adolescent and young adult cancer patients


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE – Project 2  Women of minority race/ethnicity, lower income, lower education, and rural residence have limited access to  higher quality breast cancer screening and newer technologies that can detect more cancer and reduce  unnecessary diagnostic follow-up. The proposed study will comprehensively evaluate how targeted facility-  level changes, including the use of artificial intelligence for automated mammography interpretation, can  promote greater equity in breast cancer screening outcomes. This study will generate evidence to guide  practitioners and policymakers in optimizing the quality of care in cancer screening and reducing  the unequal  burden of cancer in our society.

PI_NAMEs: LEE, CHRISTOPH I (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Academy;Adherence;Adopted;Adoption;Advanced Malignant Neoplasm;Area;Artificial Intelligence;artificial intelligence algorithm;Attention;Automobile Driving;Benchmarking;black women;Breast;Breast Cancer Detection;Breast Cancer Surveillance Consortium;breast imaging;Cancer Burden;Cancer Detection;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer invasiveness;Caring;case control;clinical practice;cohort;Communities;cost;Data;design;Diagnosis;Diagnostic;Diffusion;Digital Breast Tomosynthesis;Digital Mammography;Disease;Disparity;dosimetry;Education;Enabling Factors;Equilibrium;Equity;ethnic minority;Ethnic Origin;Evaluation;experience;follow-up;General Population;health care delivery;health equity;health equity promotion;Health equity research;Image Analysis;image guided;imager;imaging facilities;Imaging technology;improved;Income;Individual;Inequity;innovation;Insurance;Intervention;Low income;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Medicine;models and simulation;Morbidity - disease rate;mortality;multilevel analysis;National Institute on Minority Health and Health Disparities;Neighborhoods;new technology;observational cohort study;Outcome;patient navigation;Performance;Policy Maker;Population;Quality of Care;racial minority;racial minority women;radiologist;Registries;Reporting;Research;Research Design;Resources;routine screening;Rural Population;rural residence;screening;screening disparities;Screening for cancer;Sensitivity and Specificity;Services;Site;social health determinants;Societies;structural determinants;Structural Racism;Technology;Time;tool;Training;underserved community;Underserved Population;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Project 2


PHR: PROJECT NARRATIVE – Overall This Program renewal will provide evidence to improve the equity and effectiveness of breast cancer screening and surveillance. We will create risk prediction tools that perform well for all racial and ethnic groups and examine factors that influence the quality of breast imaging across radiology facilities to identify opportunities to improve care. Our findings will provide timely information to inform decision making about the frequency and type of breast cancer screening and surveillance for women, healthcare providers, and policymakers.

PI_NAMEs: KERLIKOWSKE, KARLA M;MIGLIORETTI, DIANA L (contact);TOSTESON, ANNA N. A.

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;algorithmic bias;Artificial Intelligence;artificial intelligence algorithm;Attention;Biometry;Breast Cancer Detection;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;Breast Cancer survivor;breast imaging;Cancer Etiology;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer risk;care delivery;Caring;Cessation of life;Clinical;clinical risk;Communication Research;Communities;Community Practice;comparative effectiveness;Data;Data Collection;data management;Decision Making;Digital Breast Tomosynthesis;Disparity;Early Diagnosis;Education;Effectiveness;Equity;ethnic disparity;Ethnic Origin;Ethnic Population;evidence base;Failure;Frequencies;Funding;Future;General Population;Geography;Goals;Guidelines;Harm Reduction;health disparity;health equity;Health Personnel;high risk;High Risk Woman;Housing;Image;imaging facilities;Imaging technology;improved;Income;Individual;Inequity;Infrastructure;innovation;Intervention;Leadership;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Modeling;mortality;multidisciplinary;Neighborhoods;network models;Outcome;patient oriented;Performance;Play;Policies;Policy Maker;Population;population based;Population Heterogeneity;predictive tools;programs;prospective;Provider;Public Health;public health priorities;Qualitative Research;Race;racial disparity;racial population;Radiology Specialty;Registries;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Role;Science;screening;Services;social health determinants;sociodemographics;socioeconomics;Stage at Diagnosis;Structural Racism;surveillance imaging;surveillance strategy;System;Technology;Testing;training data;Translations;Underserved Population;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Advancing Equitable Risk-based Breast Cancer Screening and Surveillance in Community Practice


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Narrative (Overall) The Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Environmental Health Sciences Core Center provides infrastructural support for research, research translation, career development and training, and community engagement to address critical knowledge gaps of lifestage vulnerability to environmental exposures.

PI_NAMEs: DOLINOY, DANA  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Advocacy;Affect;Age;Aging;anti-racism;Articulation;Asthma;Award;career;career development;Child;Chronic Disease;climate change;climate impact;climate-related health;Clinical;Collaborations;Communities;community engagement;Complex;Conceptions;Core Facility;Coupled;Data Science;data to knowledge;Development;Discipline;Disease;Education;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;Epigenetic Process;Equity;equity, diversity, and inclusion;Etiology;experience;Exposure to;Fostering;Foundations;Future;Genetic Processes;Goals;Grant;Health;health determinants;health disparity;Health Promotion;health science research;Health Sciences;Human Biology;human disease;improved;Individual;Infant;innovation;Institution;Investigation;Knowledge;Leadership;Learning;Life;life span;member;Metabolic syndrome;Michigan;middle age;Mission;multiple omics;National Institute of Environmental Health Sciences;Neurodegenerative Disorders;next generation;novel;Outcome;Patients;Pilot Projects;Policies;population health;practical application;Predisposition;prenatal;present value;prevent;Program Development;programs;public health intervention;reproductive;Research;Research Activity;Research Personnel;Research Support;Resources;Role;Science;Scientist;Strategic Planning;Structure;Superfund;Toxicology;Training;Training Support;Translating;translational impact;Translational Research;Translations;Universities

PROJECT_TITLE: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Modified Public Health Relevance Section We propose to establish the Midwest Center for Cryo-Electron Tomography (MCCET) at the University of Wisconsin, Madison, a National Service Network Hub for Cryo-Electron Tomography. The MCCET will provide national and international access to state-of-the-art equipment and well-trained technical staff to support the growing need for cryo-ET of biomedically-relevant specimens from isolated macromolecules to tissue from organisms. The MCCET will enable researchers, inside and outside of the national network of service centers, to prepare specimens suitable for on-site cryo-ET data acquisition and data processing, and to train and cross-train in a broad-range of cryo-ET workflows.

PI_NAMEs: WRIGHT, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Administrator;Biochemistry;Biological Sciences;Carbon;Cell Culture Techniques;Complex;computer scientist;computerized data processing;Computers;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;data acquisition;Data Collection;Database Management Systems;Development;Devices;Discipline;Electron Microscope;Electron Microscopy;Ensure;Equipment;evaporation;experience;Fluorescence;Grant;Human Resources;Image;Image Analysis;image processing;improved;Individual;innovation;Institution;instrumentation;International;Ions;Laboratory culture;Light Microscope;macromolecule;materials science;member;Methods;Midwestern United States;Molecular Biology;operation;Organelles;Organism;Pattern;Postdoctoral Fellow;Preparation;preservation;pressure;public health relevance;Recording of previous events;recruit;Research;Research Personnel;Resources;Robot;Role;Sampling;Scanning;Services;Site;skills;small molecule;Specimen;Standardization;System;Teacher Professional Development;Technology;technology development;Tissues;Training;Training Activity;United States National Institutes of Health;Universities;Validation;virtual;Wisconsin

PROJECT_TITLE: The Midwest Center for Cryo-Electron Tomography


NIH_SPENDING_CATS: Aging

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PI_NAMEs: LITHGOW, GORDON J (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Administrator;Aging;Award;Biology of Aging;Breathing;California;career;Collaborations;Communication;Communication Methods;Communities;Country;Decision Making;design;Development;Faculty;Financial Support;Geroscientist;Goals;Human Resources;Infrastructure;innovation;Lead;Measures;Mentors;Modeling;next generation;operation;Outcome;outreach;Pilot Projects;Policies;Postdoctoral Fellow;Principal Investigator;programs;Published Comment;Reporting;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Project Grants;Resource Development;Resources;Services;Shock;Site Visit;Source;Specialist;Structure;Technology;Training;Training Activity;United States National Institutes of Health;Universities;verdin photosensitizer;webinar;Writing

PROJECT_TITLE: USC-Buck Institute Nathan Shock Admin Core


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative Hepatitis B virus (HBV) is a common cause of chronic liver diseases such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma, affecting 1.25 million people in the United States and 240 million worldwide. The overall goal of this application is to determine the importance and underlying molecular mechanisms of apolipoprotein E in HBV infection and morphogenesis. The outcomes of this application will provide novel targets for discovery and development of new classes of antiviral drugs towards elimination of chronic HBV infection.

PI_NAMEs: LUO, GUANGXIANG GEORGE (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Affect;Anti-viral Agents;Anti-viral Therapy;Antibodies;antiviral drug development;Apolipoprotein E;Binding;Biological Assay;Biology;Cell Culture System;Cell Culture Techniques;Cell Line;Cessation of life;Chronic;Chronic Hepatitis;Chronic Hepatitis B;chronic liver disease;Circular DNA;Cirrhosis;Clinical;Co-Immunoprecipitations;Cysteine;Data;Development;DNA Viruses;drug development;drug discovery;Electron Microscopy;env Gene Products;Family;Family member;Fibrosis;Genes;Genome;global health;Glucosamine;glycosylation;Glypican;Goals;Hepadnaviridae;Heparan Sulfate Proteoglycan;Heparin;Hepatitis B;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;Human;Immunologics;in vivo;Individual;Infection;Infectious hepatitides;inhibitor;Interferons;knock-down;Knock-out;Knowledge;LDL-Receptor Related Protein 1;Liver diseases;Low Density Lipoprotein Receptor;Maps;Mediating;Mediation;Molecular;Molecular Target;Monoclonal Antibodies;Morphogenesis;Mus;Mutagenesis;novel;nucleoside analog;Outcome;Patients;Persons;Phosphorylation;Physiological;Play;prevent;Primary carcinoma of the liver cells;Production;Proteins;proteoglycan core protein;prototype;Public Health;receptor;receptor binding;Risk;Role;Small Interfering RNA;Surface;Testing;Therapeutic;United States;Vaccines;Viral;Viral hepatitis;Virion;Virus;Virus Diseases;virus envelope;Virus Replication;World Health Organization

PROJECT_TITLE: Role of Human Apolipoprotein E in Hepatitis B Virus Infection andMorphogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The escalating drug overdose crisis in the US, exacerbated by the COVID-19 pandemic, disproportionately affects African American and American Indian/Alaska Native populations. The proposed project seeks to optimize harm reduction strategies through mathematical modeling and decision tools developed in collaboration with health departments and community stakeholders. By assessing the effectiveness and health equity outcomes of these interventions and tailoring strategies to local contexts in six jurisdictions, we aim to provide actionable insights to guide resource allocation and the implementation of evidence-based interventions to address the overdose epidemic.

PI_NAMEs: MARSHALL, BRANDON DAVID LEWIS;ZANG, XIAO  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: access disparities;Address;Adoption;Affect;African American;Alaska Native;Alaska Native population;American Indian Population;American Indians;Cessation of life;Collaborations;Communities;community partners;cost;cost effectiveness;Cost Effectiveness Analysis;Country;COVID-19 pandemic;Data;data resource;Death Rate;Decision Making;demographics;design;Detection;effectiveness evaluation;Ensure;Environment;Epidemic;Equity;ethnic disparity;Ethnic equity;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;Frequencies;Funding;Generations;Geography;Goals;Harm Reduction;harm reduction programs;Health;health equity;Helping to End Addiction Long-term;implementation science;implementation tool;improved;Individual;Infrastructure;innovation;insight;Intervention;Interview;Legal;Massachusetts;mathematical model;Minnesota;Missouri;Modeling;naloxone dispensing;National Institute of Drug Abuse;Nature;Nevada;New York City;novel;Opiate Addiction;Opioid;opioid misuse;opioid mortality;opioid overdose;Outcome;Output;Overdose;overdose death;overdose education;overdose prevention;Overdose reversal;Pharmaceutical Preparations;Policies;Policy Making;Prevention strategy;Process;programs;Public Health;Race;racial disparity;racial minority population;Research;Resource Allocation;resource guides;Resources;Rhode Island;scale up;Services;simulation;Speed;Statutes and Laws;Structure;success;support tools;Technology;Testing;Time;tool;United States Dept. of Health and Human Services;United States National Institutes of Health;Visualization;web based interface;web-based tool;Work

PROJECT_TITLE: Reversing Overdose Epidemics through Simulation, Collaboration, and Unified Efforts (RESCUE)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive obstructive lung disease caused by cigarette smoke exposure with few effective therapies. The role of mitochondrial dysfunction and cellular senescence, a state of cell arrest, in COPD pathogenesis remain unknown and an area of high scientific interest. This work will define how adenine nucleotide translocase (ANT2), a mitochondrial ADP/ATP translocase, influences mitochondrial dysfunction that drives cellular senescence and abnormal repair of the lung epithelium, thus opening the potential for ANT as a therapeutic target for COPD.

PI_NAMEs: KLIMENT, CORRINE R (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Abnormal Epithelial Cell;Adenine Nucleotide Translocase;airway obstruction;Alveolar;alveolar epithelium;Antioxidants;Area;Automobile Driving;bronchial epithelium;Cause of Death;Cell Aging;Cell Cycle Arrest;Cell Line;Cell Physiology;Cells;Cellular Metabolic Process;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Data;Disease Progression;DNA Damage;effective therapy;Epithelial Cells;epithelial repair;Equilibrium;Excision;exposure to cigarette smoke;gain of function;Gene Expression;Genus Hippocampus;Goals;Homeostasis;Human;improved;In Vitro;in vivo;in vivo Model;Inflammation;inhibitor;Injury;insight;interest;knock-down;Knock-out;Knockout Mice;Knowledge;loss of function;Lung;Lung Diseases;lung repair;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mouse model;Mus;NADH;novel;novel therapeutic intervention;Obstructive Lung Diseases;oncoprotein p21;Organoids;Outcome;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;prevent;Process;Production;progenitor;programs;Proliferating;Pulmonary Emphysema;Reactive Oxygen Species;repaired;Respiration;response;restoration;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Slice;stem cell function;stem cells;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;Transcriptional Regulation;United States;Work

PROJECT_TITLE: The Role of Adenine Nucleotide Translocase in Mitochondrial Dysfunction Associated Senescence in Chronic Obstructive Pulmonary Disease (COPD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Housing instability — a lack of stable, secure, and adequate housing that results from poverty and structural racism — is a major social determinant of health for HIV and one of the reasons for the striking lack of progress toward goals to end the HIV epidemic in the US. In this study, we will rigorously evaluate a potentially transformative city-level transitional housing program for people with HIV experiencing housing instability, leveraging lottery drawings from a waitlist to estimate causal effects and conducting an implementation evaluation. This approach could significantly impact both HIV- and non-HIV-related outcomes, and this study will provide critical evidence to policymakers at a time when many cities are considering housing support programs and various other anti-poverty interventions (e.g., guaranteed income).

PI_NAMEs: RICHTERMAN, AARON G (contact)

PROJECT_TERMS: Address;Affect;antiretroviral therapy;arm;behavioral economics;black men;Caring;Case Management;Cities;Collaborations;cost;Counseling;Data;Development;Disadvantaged;Discrimination;economic outcome;Economics;effectiveness/implementation hybrid;Employment;Enrollment;Epidemic;Evaluation;experience;food security;Funding;Future;gender minority health;Goals;Health;health care availability;health equity;health inequalities;Healthcare;Hispanic;HIV;HIV disparities;HIV Infections;HIV/AIDS;Homelessness;Housing;housing instability;implementation evaluation;implementation science;improved outcome;Incidence;Income;Inequity;innovation;insight;Intervention;Interview;Investments;Latino;lifetime risk;Long-Term Effects;Medical;meetings;men;Methodology;Methods;Modernization;multidisciplinary;Neighborhoods;novel;Outcome;Pathway interactions;payment;Personal Satisfaction;Persons;Pharmacy facility;Philadelphia;Policies;Policy Maker;Population;Positioning Attribute;Poverty;poverty reduction;Program Acceptability;programs;psychological distress;psychological outcomes;Public Health;Race;racial disparity;Research;Risk Reduction;scale up;screening;Secure;Security;Services;Sexual and Gender Minorities;social health determinants;social stigma;Social stratification;Spottings;Structural Racism;substance use;supported housing;Surveys;therapy adherence;Time;transitional housing;transmission process;treatment as prevention;United States Dept. of Health and Human Services;United States National Institutes of Health;uptake;Viral;Waiting Lists;Woman

PROJECT_TITLE: A Type 1 Hybrid Effectiveness-Implementation Evaluation of a City-Level Transitional Housing Program's Effects on Health, Economic, and Psychologic Outcomes Among People with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (50)]