FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The goals of the Intellectual and Disabilities Research Center at Boston Children's Hospital and Harvard Medical School are threefold: support outstanding, trans-disciplinary research into the causes of neurodevelopmental disorders, train a diverse next generation of researchers in this field and most importantly develop new therapies for individuals and families affected with these disorders. The Center is composed of four scientific core facilities, each focused on a different level of investigation and complementing each other, ranging from genetics, cellular imaging, animal behavior and physiology to clinical trials.

PI_NAMEs: POMEROY, SCOTT LOREN;SAHIN, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Address;Advocacy;Affect;age group;Animal Behavior;Animal Model;Animals;Area;awake;base;Basic Science;behavior test;Behavioral;behavioral phenotyping;Biochemical;Bioinformatics;Biological Markers;Biological Models;Biology;Boston;Brain;Caliber;cellular imaging;Clinic;Clinical;clinical phenotype;Clinical Research;clinical translation;Clinical Trials;Collaborations;Collection;Communities;community engagement;Core Facility;Dedications;design;Development;developmental disease;Disability research;Discipline;Disease;disease model;drug discovery;Drug Screening;educational atmosphere;Effectiveness;Electroencephalography;Electrophysiology (science);Encapsulated;Etiology;Family;Fostering;Funding;Generations;Genes;Genetic;genetic analysis;genome editing;Genotype;Goals;Hospitals;Human;Image;Image Analysis;improved;In Vitro;in vivo;Individual;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;Investments;Laboratories;Leadership;lectures;Measures;medical schools;meetings;Mentors;model organism;Modeling;Modification;Molecular;Mus;neurobehavioral;Neurodevelopmental Disorder;Neurons;Neurosciences;next generation;next generation sequencing;non-genetic;novel;novel therapeutics;Organ;outreach;Pathogenesis;patient - derived stem cells;patient advocacy group;patient population;patient stratification;Patients;Pediatric Hospitals;Phenotype;Physiological;Physiology;pre-clinical;Prevention strategy;programs;recruit;Research;research facility;Research Personnel;Research Priority;Research Project Grants;Resources;Rodent;Role;Services;Side;stem cell model;stem cells;symposium;targeted treatment;Technology;technology development;technology validation;Therapeutic;tissue fixing;tool;Training;Training Programs;translational potential;Translational Research;Translations;treatment strategy;Underrepresented Minority;United States National Institutes of Health;Vision;Visualization;web site

PROJECT_TITLE: Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center


ADMINISTERING_IC: HD

ARRA_FUNDED: N

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: MA

PI_NAMEs: UMEMORI, HISASHI  (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;analysis pipeline;animal imaging;Animals;Array tomography;Attention;awake;Boston;Candidate Disease Gene;Cells;cellular imaging;Collaborations;Communities;Complex;Computer software;Consultations;Custom;Data;data acquisition;Data Analyses;design;Development;digital imaging;Disease;Education;Educational workshop;Equipment;Experimental Designs;experimental study;Fund Raising;Funding;Funding Agency;Future;Goals;Grant;Image;Image Analysis;imaging approach;imaging modality;Imaging Techniques;Imaging technology;In Vitro;in vivo;in vivo imaging;Individual;Institution;instrument;instrumentation;Intellectual and Developmental Disabilities Research Centers;Interdisciplinary Study;interest;Knowledge;Laboratories;Lasers;Maintenance;medical schools;member;Microscope;microscopic imaging;Microscopy;model organism;Monitor;multi-photon;multiphoton imaging;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neurologic;Neurology;Neurons;new technology;novel;optogenetics;Organ;Pathologic;Pediatric Hospitals;Play;Population;Privatization;Procedures;programs;Proteins;Quality Control;quantitative imaging;Reliability of Results;Reproducibility of Results;Research;Research Personnel;Resolution;Resource Allocation;Resources;Role;Sampling;Scanning;Services;Signal Transduction;Site;Statistical Data Interpretation;superresolution microscopy;System;Techniques;Technology;Time;tissue fixing;Training;Training Programs;ultra high resolution;United States National Institutes of Health;Vendor;Visualization;Work

PROJECT_TITLE: Cellular Imaging Core (CIC)


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: OWINGS MILLS

ORG_NAME: EMOCHA MOBILE HEALTH, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Methadone is an effective treatment for opioid use disorder (OUD) yet historically the care delivery model requires directly-observed therapy (DOT) at opioid treatment programs which is a barrier to clients. The pandemic initially exacerbated those challenges but ultimately led to the revision of regulations, paving the way for more flexible models of care. Our prior Phase I research demonstrated the feasibility, safety, and acceptability of an innovative mobile health platform to provide asynchronous, video DOT and to screen for symptoms of COVID-19 for patients treated for OUD with methadone; this proposal aims to test the implementation of video direct observe therapy (video-DOT) for methadone across a large, multisite OTP organization via a Hybrid Type 2 Effectiveness Implementation study with stepped wedge cluster randomized trial design.

PI_NAMEs: HALLGREN, KEVIN A.;SEIGUER, SEBASTIAN  (contact);TSUI, JUDITH

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: acceptability and feasibility;Calendar;care delivery;Caring;catalyst;Client;Clinic;Clinical;Cluster randomized trial;COVID-19 pandemic;COVID-19 patient;Data;design;Directly Observed Therapy;Dose;effective therapy;effectiveness/implementation study;Electronic Health Record;Evaluation;Event;Family;Feedback;flexibility;formative assessment;Funding;future implementation;Graduation Rates;Guidelines;handheld mobile device;Health Services Accessibility;Home;Hybrids;implementation facilitators;improved;Ingestion;innovation;Intervention;Interview;Medical;Methadone;methadone treatment;mHealth;Modeling;National Institute of Drug Abuse;Nurses;Observational Study;opioid epidemic;opioid treatment program;opioid use disorder;Outcome;pandemic disease;pandemic potential;Patient-Centered Care;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;post implementation;primary outcome;Professional counselor;Provider;Randomized;randomized trial;Regulation;Research;Risk;Safety;Sampling;secondary outcome;Secure;Service delivery model;Services;Site;smartphone application;support tools;Symptoms;Testing;Thinking;Time;Toxic effect;Training;Travel;treatment adherence;treatment duration;Treatment outcome;trial design;United States Substance Abuse and Mental Health Services Administration;Visit;Work

PROJECT_TITLE: Video observed therapy to enhance flexibility and reduce in-person visits for patients treated with methadone in a multi-site opioid treatment program


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: Project Narrative This proposal investigates how mRNAs with early stop codons are repressed. The proposal focuses on the biochemistry and requirements for effectors of the mRNA cleavage step, and the role that ribosomes and the protein UPF1 have in mRNA targeting. Results from this work will illuminate mechanisms of translation and mRNA degradation for a class of genetic mutations (early stop codons) present in a substantial fraction (~11%) of disease-causing alleles.

PI_NAMEs: ARRIBERE, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Alleles;Animals;ATP phosphohydrolase;Binding;Biochemical;Biochemical Reaction;Biochemistry;Caenorhabditis elegans;Cells;Complex;Confusion;CRISPR/Cas technology;Cryoelectron Microscopy;Dependence;design;Dimerization;Disease;disease-causing mutation;Dissociation;DNA Sequence Alteration;Event;experimental study;Funding;Genetic;Genetic Diseases;Genetic Variation;Goals;Heart;Hereditary Disease;Human;human disease;In Vitro;in vivo;Licensing;Maps;Mediating;Messenger RNA;Modeling;Molecular;mRNA Decay;mRNA Transcript Degradation;mutant;Mutation;nanopore;Nature;Nonsense Codon;nuclease;Pathway interactions;Phenotype;Phosphorylation;Point Mutation;premature;Process;Production;Protein Biosynthesis;protein degradation;Protein Truncation;Proteins;Reaction;recruit;Reporting;Repression;Ribosomes;RNA;RNA Binding;RNA Biochemistry;RNA Decay;RNA Helicase;Role;Signal Transduction;Site;structural biology;Structure;System;targeted treatment;Techniques;Terminator Codon;Testing;Therapeutic;transcriptome sequencing;Translations;Work

PROJECT_TITLE: Mechanisms of Translational Surveillance

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Neurosciences;Prevention;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE There are different types of non-bleeding strokes and identifying the correct cause of a stroke, for example a stroke secondary to heart disease, is critical in the proper treatment of patients. In many cases, a clear source of the stroke is not recognized and this may be due to inadequate evaluation of heart function. More advanced, focused imaging of the heart may provide the necessary information to critically guide future patient care, in order to prevent recurrent strokes and poor patient outcomes.

PI_NAMEs: JOHANSEN, MICHELLE C. (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Address;adjudication;anatomic imaging;Anatomy;Angiography;Anticoagulation;Aorta;aortic arch;Arrhythmia;Atherosclerosis;Atrial Fibrillation;auricular appendage;Blood Platelets;Cardiac;cardiovascular imaging;career;Cauliflower;Cessation of life;Clinical;clinical practice;Clinical Trials;cohort;computerized;Coronary;cost;Data;Death Rate;Development;Diagnosis;disability;Disease;Echocardiography;Electrocardiogram;embolic stroke;Endothelium;Enrollment;Evaluation;Evidence based treatment;Family;Functional disorder;functional outcomes;Funding;Future;Grant;Heart Atrium;Heart Diseases;heart function;heart imaging;high risk;hospital readmission;imaging biomarker;imaging modality;Imaging Techniques;improved;indexing;Individual;insight;Ischemic Stroke;Lead;Left;Left Atrial Function;Left atrial structure;Link;Longterm Follow-up;Measures;Mechanics;Methodology;Monitor;Outcome;Pathology;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;post stroke;prevent;Prevention;Preventive therapy;prospective;readmission rates;recruit;Recurrence;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Role;Science;Scientist;Secondary to;Shapes;skills;Source;Stroke;stroke outcome;stroke patient;stroke risk;stroke therapy;Structure;Tachyarrhythmias;Testing;Therapeutic;Thrombosis;tomography;Training;treatment strategy;Work;X-Ray Computed Tomography

PROJECT_TITLE: Defining the role of Atrial Cardiopathy and Subclinical Cardiac Disease in Acute Ischemic Stroke

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: At a time of unprecedented, forced migration coupled with limited access to mental health resources, this K01 application focuses on developing skills and knowledge needed to adapt, scale up and sustain community- based mental health prevention and care interventions for refugees across the displacement continuum. The proposed study will advance the field by integrating human-centered design and implementation science to adapt and deliver a multiple family group intervention that responds to the multi-level needs of refugees and has high likelihood of adoption, and impact. The candidate’s expertise in these methods will contribute to improving access to care for refugees and war-affected populations in the U.S. and globally with implications for U.S. military families as well as trauma-affected communities impacted by mental health disparities in the U.S. and globally.

PI_NAMEs: BUNN, MARY  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;Applied Skills;Area;care systems;career;Caring;Characteristics;Chicago;Child;Child Mental Health;clinical practice;Coffee;Collaborations;Communities;community collaboration;community empowerment;community organizations;community partners;community partnership;Community Practice;Community Services;community setting;Complex;Conflict (Psychology);coping;Country;Coupled;Data;Education;Effectiveness;Effectiveness of Interventions;effectiveness/implementation design;evidence base;Evidence based intervention;experience;Family;Family Relationship;Funding;Future;Goals;group intervention;health disparity;Health Resources;Health Services Accessibility;help-seeking behavior;Home;human centered design;hybrid type 1 design;implementation design;implementation evaluation;implementation science;Improve Access;Income;Individual;Intervention;Knowledge;Life Experience;low and middle-income countries;Mediating;men;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Methods;migration;military family;Modeling;multidisciplinary;National Institute of Mental Health;Outcome;Partnership Practice;peer;Personal Satisfaction;Pilot Projects;Population;practice setting;preference;Prevention;prevention service;preventive intervention;Process;programs;Provider;psychosocial;Randomized;Refugee Camp;Refugees;Research;Research Personnel;Research Priority;Research Project Grants;research study;Resources;Risk;Risk Factors;scale up;service organization;Service setting;Services;Shapes;skills;social;Social Network;social relationships;Stress and Coping;stressor;Structure;Syria;System;Testing;Time;tool;Training;Trauma;trauma exposure;trial design;Universities;uptake;urban area;usability;violence exposure;War;Woman;Work

PROJECT_TITLE: Leveraging Implementation Science and Design Methods to Sustain Community-Based Mental Health Services for Refugees

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Lung cancer screening with annual low-dose chest CT is effective at reducing lung cancer mortality in high-risk current and former smokers; however, the mortality benefits of screening may be limited by poor adherence to annual follow-up after negative or positive lung cancer screens. The proposed research will address this implementation gap by identifying barriers and facilitators to screening follow-up in community settings and adapting and evaluating evidence-based interventions to support screening follow-up at diverse community partner sites.

PI_NAMEs: TRIPLETTE, MATTHEW ADAM (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Achievement;Address;Adherence;adherence rate;arm;Black race;Cancer Etiology;care coordination;care systems;Caring;Cessation of life;chest computed tomography;Clinic;Clinical;clinical practice;Clinical Trials;Communities;community academic partnership;community partners;community setting;Comprehensive Cancer Center;Comprehensive Health Care;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data;Decentralization;Diagnosis;Disparate;Disparity;disparity reduction;Dose;Effectiveness;effectiveness evaluation;effectiveness measure;effectiveness/implementation trial;Elements;Eligibility Determination;Ensure;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnography;Evaluation;evidence base;Evidence based intervention;experience;follow-up;former smoker;Goals;Guidelines;Health Disparities Research;health disparity;high risk;Hispanic Populations;implementation evaluation;implementation framework;implementation intervention;improved;innovation;Intervention;intervention program;Interview;Knowledge;lung cancer screening;Maintenance;Malignant neoplasm of lung;Managed Care;Measures;mortality;Multicenter Studies;National Institute on Minority Health and Health Disparities;Observational Study;Pathway interactions;Patient Care;Patients;personalized approach;Population;Population Heterogeneity;pragmatic intervention;primary care provider;Process;programs;prospective;Provider;Race;racial disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reduce health disparities;Research;Resource-limited setting;routine screening;Rural;rural disparities;Rural Population;rurality;screening;Screening for cancer;screening program;Site;Socioeconomic Status;socioeconomics;Standardization;standardized care;Structure;System;Testing;therapy design;Translating;Translations;United States;United States National Institutes of Health;urban disparity;urban setting;Washington;Work

PROJECT_TITLE: Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cachexia;Cancer;Clinical Research;Digestive Diseases;Neurosciences;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PEDIATRICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Involuntary weight loss, anorexia, fatigue, and exercise intolerance are common in patients with cancer. New research demonstrates that these problems limit quality of life for many patients, and also are a significant contributor to risk of death. Our studies are designed to investigate the ways in which cancer leads to these disabling changes in behavior and metabolism to better understand how this might be treated.

PI_NAMEs: GROSSBERG, AARON  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acute;acute stress;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Animals;Anorexia;Atrophic;Attenuated;Behavior;Behavioral;behavioral phenotyping;behavioral response;biological adaptation to stress;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;cancer type;Cardiac;Cardiovascular system;Catabolism;Chronic;Chronic Disease;Chronic stress;clinical translation;Clinical Trials Design;Collaborations;Corticosterone;Corticotropin-Releasing Hormone;Data;Dedications;defined contribution;density;design;Disabling;Disease;Energy Metabolism;Evolution;exercise intolerance;Exhibits;experience;Fatigue;functional decline;Functional disorder;Genetic;Glucocorticoids;Goals;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impairment;Inflammatory;Intervention;Laboratories;Lethargies;Life;Malignant Neoplasms;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolic syndrome;Metabolism;Modeling;Morbidity - disease rate;mortality risk;Motivation;mouse model;Mus;Muscle;Muscular Atrophy;Nerve;Neuroendocrinology;neuroinflammation;Neurons;Neurosecretory Systems;Neurotransmitters;new therapeutic target;Norepinephrine;novel;novel therapeutics;Observational Study;Organ;Organism;Output;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathologic;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase II Clinical Trials;Phenotype;Physical Function;Physiological;Plasma;Pre-Clinical Model;Prevention;prospective;Quality of life;Reagent;Research;response;Role;Sick Role;Signal Transduction;Skeletal Muscle;Stress;Sympathetic Nervous System;synergism;Systemic disease;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Tissues;tumor;tumor growth;wasting

PROJECT_TITLE: PQ6: Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The training program “Convergent Graduate Training in Systems Biology at Yale” will prepare students to carry out cutting-edge biomedical research using a systems biology approach that will result in the enhancement of public health in the United States.

PI_NAMEs: MILLER-JENSEN, KATHRYN ;O'HERN, COREY  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Systems Biology;Training

PROJECT_TITLE: Convergent graduate training in systems biology at Yale

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Cancer;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: Project Narrative: Despite their lack of a fixed structure, disordered proteins have emerged as central drivers of biological function, with key roles in cell signaling, transcription, and genome organization, all of which contribute to diseases ranging from viral infections to cancer. Although clear examples in which disordered proteins are essential for disease progression exist, our understanding of the role of intrinsically disordered regions in disease etiology is limited. This proposal will study disordered protein-nucleic acid interactions in SARS-CoV-2 and in the context of cancer using a collection of single- molecule techniques.

PI_NAMEs: ALSTON, JHULLIAN JAMILLE (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 2019-nCoV;Adopted;Affinity;Anti-viral Agents;Apoptosis;Architecture;Award;Behavior;betacoronavirus;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;biophysical properties;biophysical techniques;Biophysics;Cancer Biology;cancer type;Cancerous;career;cell growth;Cell Physiology;Cells;Cessation of life;Charge;Chimeric Proteins;Chromosomal translocation;Collection;combat;Computational Technique;Coronavirus;Coronavirus nucleocapsid protein;COVID-19;COVID-19 pandemic;Development;dimer;Dimerization;Disease;Disease Outbreaks;Disease Progression;DNA Binding Domain;DNA Repair;Elements;Enhancers;Etiology;Event;Family;Fluorescence;fluorescence imaging;Fluorescence Spectroscopy;Functional disorder;Fusion Oncogene Proteins;Gene Expression;Genes;Genetic Transcription;Genome;genomic RNA;Grain;Human;improved;In Vitro;in vitro Assay;in vivo;insight;Intrinsic drive;Knowledge;Lead;Length;Malignant Neoplasms;Mediating;member;Microscopy;Middle East Respiratory Syndrome;Modeling;Molecular;Molecular Conformation;molecular imaging;molecular modeling;novel;Nucleic Acids;Nucleocapsid;Nucleocapsid Proteins;Oncogenes;Oncogenic;Output;Phase;Physical condensation;Play;Postdoctoral Fellow;Process;programs;Proliferating;protein function;Proteins;rational design;Regulation;Research;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Role;Severe Acute Respiratory Syndrome;Signal Transduction;simulation;single molecule;Site;Specificity;Spectrum Analysis;Structure;success;superresolution microscopy;Surface;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;transcription factor;Transcriptional Regulation;Viral Genome;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Single Molecule Biophysics of Intrinsically Disordered Proteins in Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Patient Safety

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Medicare’s Merit-based Incentive Payment System (MIPS) is a value-based payment model designed to improve healthcare value by adjusting clinician payments based on cost and quality measures, including recently introduced patient-reported outcome measures. This study aims to evaluate the impact of MIPS on heart failure care by determining the effect of routine patient-reported outcome assessment on heart failure quality of life, and evaluating the association between MIPS and heart failure therapy patterns, mortality and cost. These findings will impact heart failure treatment and patient outcomes by guiding policy-makers in the design of future value-based payment models.

PI_NAMEs: SANDHU, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adrenergic beta-Antagonists;Advisory Committees;Age;Award;Cardiac rehabilitation;Cardiovascular system;care outcomes;career;Caring;Cessation of life;Clinic;Clinic Visits;Clinical;clinical care;clinical decision-making;clinical practice;Clinical Trials;Collection;cost;Cost Measures;cost-effectiveness evaluation;Data;Data Collection;Data Set;Death Rate;design;Development;dosage;Effectiveness;Electronics;Enrollment;Ensure;evidence base;experience;Exposure to;Foundations;Funding;Future;Goals;Growth;Guidelines;health care quality;Health Policy;health related quality of life;Health Services;Healthcare;Heart failure;heart failure with reduced ejection fraction;hospital readmission;implementation evaluation;implementation trial;improved;improved outcome;incentive program;Incentives;Instruction;Interruption;Intervention;Knowledge;Lead;Learning;Measurement;Measures;Medicare;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modality;model design;Modeling;models and simulation;Morbidity - disease rate;mortality;Multicenter Trials;National Health Policy;Outcome;Outcome Assessment;Outcome Measure;Patient Care;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;payment;Performance;Pharmaceutical Preparations;Policy Analysis;Policy Maker;programs;Quality of Care;Quality of life;Randomized;randomized trial;Recommendation;Reporting;Research;Research Personnel;Resources;response;Sampling;Series;skills;Statistical Methods;statistics;Surveys;symposium;System;Testing;Time;tool;Training;treatment as usual;Treatment Failure;Treatment outcome;trend;United States;uptake;Work

PROJECT_TITLE: The Effect of Value-based Payment on Heart Failure Quality of Care (Value-HF)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Neurodegenerative;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Despite being the most common muscle disease after the age of 50, inclusion body myositis (IBM) remains of unclear etiology and refractory to any form of treatment, with almost all patients eventually becoming wheelchair dependent. Herein, we propose that the mitochondria play a primary role in IBM, and we plan on evaluating the mitochondrial function by a series of very innovative techniques. Our proposal has the potential to clarify underlying disease mechanisms, and identify new diagnostic tools and therapeutic targets.

PI_NAMEs: NADDAF, ELIE  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Age;Aging;aging related disease;Alzheimer's Disease;Antigens;ATP Synthesis Pathway;Autophagocytosis;Bioenergetics;Biogenesis;Biology;Biopsy;career development;CD8B1 gene;Cell Physiology;Cell Survival;Clinical Pathways;Clinical Trials;Coupling;cytochrome c oxidase;Data;Development Plans;diagnostic biomarker;diagnostic tool;Disease;Doctor of Philosophy;Electron Microscopy;Etiology;evidence base;Face;Failure;Fiber;Future;Genes;Goals;HLA Antigens;Immune;Immunotherapy;Impairment;Inclusion Body Myositis;Infiltration;Inflammatory;Inflammatory Infiltrate;innovation;insight;Institution;Laboratories;Link;Lipids;liquid chromatography mass spectrometry;Literature;male;Medicine;Mentors;Metabolic Pathway;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morphology;mRNA sequencing;multidisciplinary;Muscle;Myopathy;Myositis;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurologist;neuromuscular;new therapeutic target;novel;novel diagnostics;Organelles;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Play;Process;Production;protein aggregation;Protein Biosynthesis;Reactive Oxygen Species;Refractory;Research;Research Personnel;Respiration;Role;Sampling;Sarcoplasmic Reticulum;Scanning Electron Microscopy;Series;Sex Differences;Shapes;skills;stable isotope;Systems Biology;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic target;Training;transcriptomics;Translational Research;Vacuole;Wheelchairs;women subjects

PROJECT_TITLE: The Role of Mitochondria in Inclusion Body Myositis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Bone metastatic prostate cancer is currently incurable, and patients typically survive only 2-3 years after diagnosis. Standard of care androgen-targeted therapy drives cancer resistance and immune evasion, contributing to cancer recurrence. This proposal aims to utilize neutrophils, the most abundant bone immune cell, as a candidate target for enhancing current therapies through neutrophil-driven anti-tumor immune response.

PI_NAMEs: MATHEW, GRINU  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Aftercare;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Therapy;Androgens;antagonist;Anti-Inflammatory Agents;anti-tumor immune response;Antitumor Response;Biological Assay;bone;Bone Diseases;Bone Marrow;Bone neoplasms;Cancer Patient;cancer recurrence;carcinogenesis;Cells;ChIP-seq;clinical translation;Clinical Trials;Co-Immunoprecipitations;conditional knockout;cytokine;cytotoxic;Development;Diagnosis;diagnostic tool;Disease;Disease Progression;Dose;efficacious treatment;Enterobacteria phage P1 Cre recombinase;Environment;enzalutamide;first responder;fracture risk;functional group;Gene Expression;Generations;Genetic;Gonadotropin Hormone Releasing Hormone;Growth;high risk;Hormones;Immune;Immune Evasion;Immune response;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;inhibitor;knock-down;Knock-out;Knockout Mice;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;neutrophil;new therapeutic target;Nonmetastatic;novel;Outcome;Pain;Patient-Focused Outcomes;Patients;peripheral blood;Pilot Projects;pre-clinical;prevent;Prostate;prostate cancer metastasis;prostate cancer progression;Protein-Serine-Threonine Kinases;receptor;Receptor Signaling;Receptors, Adrenergic, beta-1;Regulation;Research;Research Design;Resistance;response;Role;Signal Transduction;Site;standard of care;Stanolone;targeted treatment;Testing;Testosterone;Therapeutic;therapy outcome;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;treatment group;tumor;tumor growth;tumor immunology

PROJECT_TITLE: Leveraging PMN immune response to overcome ADT resistance in bone metastatic prostate cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

PHR: Project Narrative  Dementia with Lewy bodies (DLB) is an aging disorder that can harm thinking, memory, movements, sleep, and behavior. Because it is difficult to diagnose DLB, particularly early in its disease course, many individuals with DLB experience long delays in receiving a diagnosis, which then delays interventions and causes significant caregiver burden. To address these delays, this study will investigate wearable technologies and standard clinical observations that together have the potential to improve the diagnosis of early DLB.

PI_NAMEs: TSUANG, DEBBY WEN (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;actigraphy;Address;Adverse effects;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Antipsychotic Agents;Behavior;Behavior monitoring;Behavioral;Biotechnology;Caregiver Burden;Caring;Clinical;Clinical assessments;clinical care;clinical diagnosis;Clinical Trials;Cognition;Cognitive;Consensus;Data;Dementia;Dementia with Lewy Bodies;Diagnosis;diagnostic criteria;diagnostic value;Discrimination;Disease;Disease Progression;Early Diagnosis;Ecological momentary assessment;efficacy evaluation;Engineering;Exclusion;experience;Exposure to;feasibility testing;Future;Impaired cognition;improved;Individual;informant;Infrastructure;Intervention;Measurement;Measures;Medical;medical specialties;Memory;Methods;mild cognitive impairment;Motor;Movement;Nature;new technology;novel;Patients;Pharmaceutical Preparations;Phase;Polysomnography;Population;predictive modeling;Prevention trial;Probability;rate of change;Research;Research Infrastructure;Research Personnel;Risk;risk prediction;Sleep;Symptoms;Syndrome;Thinking;Time;Treatment Efficacy;wearable data;wearable device;wearable sensor technology

PROJECT_TITLE: Use of wearable sensors to improve the early diagnosis of DLB


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PUBLIC HEALTH RELEVANCE Integrase (IN) Strand Transfer Inhibitors (INSTIs) are first-line therapeutics used to treat people living with HIV/AIDS, which work by blocking integration of viral DNA into host chromosomes through inhibition of the HIV intasome nucleoprotein assembly, but the emergence of IN variants resistant to INSTIs is becoming a greater clinical problem. This work will make use of structural biology and complementary enzymological, biophysical, virological, and computational approaches to define mechanisms of HIV drug resistance against the latest clinically used INSTIs, identify and characterize patterns and pathways through which clinically relevant resistance arises, synthesize potent third generation INSTIs based on the concept of substrate mimicry, and use our collective tools to mechanistically explain drug potency against viral resistant variants. The results of this work will improve our understanding of this important class of drugs used to treat people living with HIV, identify mechanisms, pathways, and patterns of clinically relevant resistance to INSTIs, and suggest specific guidelines for their rational improvement, thus providing realistic strategies for combatting drug resistance to HIV.

PI_NAMEs: LYUMKIS, DMITRY  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Active Sites;Address;Affect;analog;Anti-Retroviral Agents;antiretroviral therapy;Appearance;base;Binding;Biochemical;Biological Assay;Biophysics;Cell Culture Techniques;Chromatin;Chromosomes;Clinic;Clinical;Clinical Pathways;clinically relevant;Collaborations;Communities;Complement;Complex;Computer Models;Computing Methodologies;Cryoelectron Microscopy;Data;design;Development;Disease Progression;DNA;drug action;Drug resistance;Drug resistance pathway;Drug Targeting;Drug usage;effective therapy;Enzymes;experimental study;fighting;Foundations;Free Energy;Funding;Future;Generations;Guidelines;HIV;HIV drug resistance;HIV Integrase;HIV Integrase Inhibitors;HIV therapy;HIV-1;HIV/AIDS;human pathogen;improved;Individual;Infection;inhibitor;inhibitor therapy;insight;Integrase;interest;Kinetics;Lead;Measurement;Mediating;Methods;mimicry;mutant;Mutation;Naphthyridines;novel;Nucleoproteins;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;pre-clinical;preclinical evaluation;Prevention;Process;Productivity;prototype;public health relevance;Recording of previous events;Residual state;Resistance;Resistance development;resistance mechanism;response;Series;Spumavirus;structural biology;Structure;Techniques;Therapeutic;Therapeutic Uses;Thermodynamics;tool;treatment response;Variant;Viral;viral DNA;viral resistance;virology;Virus Integration;Virus Replication;Work

PROJECT_TITLE: Structural basis for activity of and resistance to HIV integrase inhibitors

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Vascular interventions used to treat severe atherosclerosis often fail due to the development of arterial restenosis secondary to neointimal hyperplasia. The overall goal of this proposal is to develop a novel, targeted, drug-releasing nanotherapeutic that will be administered intravenously yet localize specifically to the site of injury to prevent neointimal hyperplasia following vascular interventions in an atherosclerotic environment. Completion of these studies will position us well to start pre-IND meetings with the FDA to begin first-in-human testing with the ultimate goal to improve human health and disease.

PI_NAMEs: KIBBE, MELINA RAE (contact);STUPP, SAMUEL I

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Antioxidants;Apolipoprotein E;Arterial Fatty Streak;Arterial Injury;Arteries;Ascorbic Acid;Atherosclerosis;Balloon Angioplasty;Binding;Biodistribution;biomaterial compatibility;Biomedical Engineering;Blood;Blood Vessels;Cell Proliferation;Cessation of life;Clinical;clinical translation;Collagen;Development;Devices;Disease;Dose;Drug Kinetics;efficacy evaluation;Elements;Endothelial Cells;Endothelium;Environment;Exposure to;Familial Hypercholesterolemia;Family suidae;first-in-human;Funding;Goals;Health;Human;Hyperplasia;improved;Injections;injured;Injury;innovation;interest;Intervention;intravenous administration;Investigational Therapies;Laboratories;Modeling;Morbidity - disease rate;mortality;multimodality;nanofiber;nanotherapeutic;new technology;Nitric Oxide;novel;Oxidative Stress;peptide amphiphiles;Peptides;Pharmaceutical Preparations;porcine model;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;prevent;professor;Property;Rattus;Research;restenosis;restoration;revascularization;Safety;Secondary to;self assembly;Site;Specificity;Stents;success;Tail;targeted treatment;technology platform;Testing;Therapeutic;therapeutic target;Thinness;Thrombosis;Time;United States;United States National Institutes of Health;Urine;vascular injury;Veins;Vision

PROJECT_TITLE: Development of a multi-modal targeted nanotherapeutic to prevent restenosis in an atherosclerotic environment

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

PHR: Project Narrative Social deficits occur across a wide array of neuropsychiatric (NPD) and neurodevelopmental (NDD) disorders, persist over time, and contribute to poor outcomes and considerable public health costs. The Research Domain Criteria (RDoC) initiative operationalizes an initial set of basic, biologically meaningful components that underpin social functioning and can be used to better understand mechanisms behind social deficits seen across NPD/NDD and inform personalization of treatments. The proposed projects aims to refine and stringently validate a new quantitative comprehensive parent-report measure of key RDoC Social Processes constructs and subconstructs with the hope of unlocking etiological and treatment-oriented research in social deficits across NPD and NDD.

PI_NAMEs: HARDAN, ANTONIO  (contact);ULJAREVIC, MIRKO

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 3-Dimensional;Acceleration;Accounting;Adoption;Adult;Age;age group;aged;Assessment tool;autism spectrum disorder;autism symptoms;Brain;Calibration;Child;Clinical;clinical outcome measures;clinical practice;clinically relevant;Cognitive;Collection;Companions;computerized;Dedications;design;Development;Diagnosis;Diagnostic;diagnostic platform;Dimensions;Equation;Ethnic Origin;Etiology;Face;Feedback;Focus Groups;follow-up;Foundations;functional MRI scan;Future;Goals;Health Care Costs;Impairment;indexing;Individual;individualized medicine;Information Systems;Information Theory;instrument;Interview;Investigation;Language;Measures;mental state;Methodology;Methods;Modeling;Motivation;National Institute of Mental Health;neural network;neurobiological mechanism;Neurobiology;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;Outcome;Outcome Measure;Parents;Participant;Patient Outcomes Assessments;Perception;personalized medicine;Persons;Population;Process;Protocols documentation;Psychometrics;Public Health;Race;recruit;Reporting;Research;Research Domain Criteria;Research Personnel;response;Risk;Sampling;sex;social;social communication;social deficits;Social Functioning;Social Processes;Source;Standardization;Structure;Surveys;Testing;theories;Time;Translations;United States National Institutes of Health;Update;Youth

PROJECT_TITLE: Developing a Quantitative Assessment Tool for Characterizing Social Domains

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Drug-resistant tuberculosis (TB) remains an important threat to global public health. Early identification, at the critical juncture between outbreak and epidemic, can prevent disease and deaths due to drug-resistant TB infections. In this project, we use genetic data from TB infections and data on human mobility to advance new strategies for early detection and containment of emerging strains of drug-resistant TB.

PI_NAMEs: BROWN, TYLER STEVEN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;antimicrobial resistant infection;Award;Bayesian Analysis;Calibration;career;career development;Cellular Phone;Cessation of life;Cities;co-infection;Collection;Communicable Diseases;Computer Models;Containment;COVID-19;Data;Data Sources;Detection;Development;Disease;Disease Outbreaks;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Early Diagnosis;Early identification;Environment;Epidemic;Epidemiologist;Epidemiology;epidemiology study;Evaluation;Evolution;experience;Feedback;forging;Funding;Future;Genetic;Genetic Models;genetic signature;Genetic Variation;genomic data;genomic epidemiology;Geographic Locations;Geography;Goals;health care delivery;Health Services Accessibility;high risk;HIV;Household;Human;improved;Individual;Infection;Infectious Disease Epidemiology;infectious disease model;innovation;insight;interdisciplinary approach;Link;Location;Malaria;Maps;mathematical model;Mentors;Mentorship;Methods;microbial;microbial genomics;Migrant;Modeling;Movement;multiple data sources;Multiple drug resistant Mycobacteria Tuberculosis;Mycobacterium tuberculosis;new epidemic;novel;novel strategies;novel therapeutics;Pattern;Pharmaceutical Preparations;Physicians;Population;Population Genetics;Predisposition;prevent;Process;Public Health;public health relevance;public health research;Public Health Schools;Research;Research Activity;resistant strain;Rural;rural area;rural-urban migration;Sampling;Science;Scientist;skills;South Africa;spatial epidemiology;Specific qualifier value;surveillance strategy;Surveys;Testing;Training;Training Activity;transmission process;Tuberculosis;Uncertainty;United States National Institutes of Health;urban area;Widespread Disease;Work

PROJECT_TITLE: Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Post-Traumatic Stress Disorder (PTSD);Precision Medicine;Prevention;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose a novel digital phenotyping approach using deep learning to identify objective digital biomarkers from video-recorded interviews to predict posttraumatic stress disorder risk after Emergency Department (ED) discharge to better target early interventions and reduce delayed treatment. We will determine how candidate digital biomarkers that are designed for practical feasibility under the demanding acute care priorities in the ED add to the prognostic value of psychometric assessments and electronic health records. The proposal contributes to the NIMH’s mission aiming to “enable practical, scalable, and sustainable mental health screening and triage, and providing interventions at scale”.1

PI_NAMEs: SCHULTEBRAUCKS, KATHARINA  (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;acute stress;Admission activity;Biological;biological adaptation to stress;care systems;Caring;Cellular Phone;Charge;Chronic Post Traumatic Stress Disorder;Clinical;Clinical assessments;Clinical Data;clinical practice;clinically significant;Cognitive Therapy;cohort;Computer Vision Systems;Computing Methodologies;Consumption;cost;cost effective;COVID-19 pandemic;Data;deep learning;design;Devices;Diagnosis;Diagnostic;digital;Digital biomarker;digital measure;digital phenotyping;Disasters;Discharge Plannings;disorder risk;Early Intervention;Early treatment;Effectiveness;electronic health data;electronic health information;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency response;Emergency Situation;Emotions;Event;experience;Face;follow-up;Foundations;Future;gaze;Goals;handheld mobile device;Head Movements;health application;Health Care Costs;Healthcare Systems;high risk population;Hospitals;improved;instrument;Intervention;Interview;Life;longitudinal, prospective study;Measures;medical specialties;Medicine;Mental Depression;Mental Health;Mental Health Services;Mission;Modality;Morbidity - disease rate;multimodality;Mydriasis;National Institute of Mental Health;Natural Language Processing;Nature;neural;novel;Participant;Patient Admission;Patient Care;Patient Self-Report;Patients;Personal Satisfaction;Physiological;point of care;post-traumatic stress;Post-Traumatic Stress Disorders;predictive marker;predictive modeling;Predictive Value;Prevention;Prevention strategy;Privatization;Procedures;professional atmosphere;Prognosis;prognostic;prognostic model;prognostic performance;prognostic value;prognostication;Proxy;Psyche structure;psychologic;Psychometrics;Publishing;Reporting;Research;Research Project Grants;response;Risk;risk stratification;routine screening;screening;Severities;Speech;stress symptom;support tools;Survivors;Symptoms;Tablets;Taxes;telehealth;Testing;Time;Training;transfer learning;Trauma;trauma exposure;traumatic event;Triage;Video Recording;Videotape;Voice;Work

PROJECT_TITLE: Point-of-care prognostic modeling of PTSD risk after traumatic event exposure using digital biomarkers and clinical data from electronic health records in the emergency department setting (PREDICT)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PI_NAMEs: SMITH, NATHAN GRANT (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This K99/R00 application describes a mentoring strategy for Dr. Benjamin Freedman to gain the necessary aging biology, biomaterials, and drug delivery skill set to develop and evaluate a new cell delivery approach to augment tendon. With increased participation in recreational activities and sport, and a more active aging population, the incidence of acute and chronic tendon injuries is rising. In this project, we will develop and examine how biomaterials can dynamically recruit, expand, and release cells in vivo, which will yield improved cell delivery strategies for tendon injuries throughout aging and have broad applications to other tissues and disease states.

PI_NAMEs: FREEDMAN, BENJAMIN ROSS (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;achilles tendon;Acute;Adhesives;Adolescent;Adult;Affect;Age;age related;aged;Aging;aging population;American;Biocompatible Materials;Biology;Biology of Aging;Biomedical Engineering;career;cell age;cell growth;cell motility;Cell Proliferation;Cell Separation;Cell Therapy;Cells;Chronic;Cicatrix;clinically relevant;Collagen;Connective Tissue Diseases;Consumption;cost;design;Development;Disease;Doctor of Philosophy;Drug Delivery Systems;Engraftment;Environment;Enzymes;Exhibits;Faculty;Fatigue;Fiber;Functional disorder;Goals;healing;Homeostasis;Human;Hydrogels;Implant;improved;In Vitro;in vivo;Incidence;Individual;Infiltration;Injury;Insulin-Like Growth Factor I;Knowledge;Learning;Ligaments;Ligands;materials science;Mechanics;Mediating;Mentors;Methods;migration;Modeling;mouse model;Mucous body substance;Muscle;Musculoskeletal;musculoskeletal injury;National Research Service Awards;Natural regeneration;novel;novel strategies;Orthopedic Surgery;Orthopedics;Phase;Phenotype;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;programs;Proliferating;Property;Proteome;Recreation;recruit;repaired;Research;Research Personnel;Research Training;response;Rodent;Rodent Model;Role;scaffold;Scientist;scleraxis;senescence;Site;skills;slug;soft tissue;Sports;stem cells;Structure;success;Supporting Cell;Surface;Surgical Replantation;System;Technical Expertise;Techniques;Tendon Injuries;Tendon structure;Testing;Therapeutic;Time;Tissues;Training;viscoelasticity;Work

PROJECT_TITLE: Multifunctional tough adhesive hydrogels to recruit, expand, and deliver tendoncells during aging and injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEMSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the leading cause of death worldwide. The goal for the proposed research is to develop clinical-grade nanowired human isogenic cardiac organoids to treat cardiovascular disease.

PI_NAMEs: MEI, YING  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;Acute;Address;Allogenic;Animal Model;Animals;Attention;Bovine Serum Albumin;Cardiac;Cardiac Myocytes;cardiac repair;Cardiovascular Diseases;catalyst;Cause of Death;Cell Survival;Cells;Chemicals;Clinical;clinical development;clinical translation;Clinical Trials;Data;Development;Dissociation;Electric Conductivity;Endothelial Cells;Endothelium;Engraftment;fabrication;Family suidae;Female;Fibroblasts;functional improvement;functional restoration;Goals;Harvest;Heart;Heart Injuries;Human;human pluripotent stem cell;Immune;Implant;implantation;in vivo;Injections;innovation;Ischemia;Major Histocompatibility Complex;male;Methods;Modeling;Myocardial Infarction;Myocardial Reperfusion Injury;Myocardium;nanowire;Organoids;Pathologic;Patients;percutaneous coronary intervention;porcine model;Prognosis;Proteins;public health relevance;Rattus;Recovery of Function;Regenerative capacity;Reperfusion Injury;Reperfusion Therapy;Research;Risk;Silicon;Stromal Cells;Structure;System;Translating;Transplantation;Treatment Efficacy;Variant;Vascularization

PROJECT_TITLE: Nanowired human isogenic cardiac organoids to treat acute myocardial ischemia/reperfusion injuries


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Mental Health;Microbiome;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE One in three children in the US experience early life stress such as abuse, neglect, and household dysfunction, which puts them at greater risk of cardiovascular disease later in life. The gut microbiota are known to produce metabolites that mediate cardiovascular function. This project seeks to determine how early life stress induced changes in gut microbial composition and metabolic function leads to increased risk of cardiovascular disease.

PI_NAMEs: KEMP, KERI  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Aorta;arterial stiffness;Attenuated;Big Data;Bioinformatics;Biological Assay;blood pressure control;Blood Vessels;Butyrates;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cause of Death;Child;Chronic Disease;Chronic Kidney Failure;Clostridiaceae;Data;data integration;Development;Diet;disorder risk;dysbiosis;early experience;Early identification;Early Intervention;early life stress;Endogenous Factors;endothelial dysfunction;experience;Exposure to;Family;fatty acid supplementation;Fermentation;Functional disorder;Future;Goals;gut microbiota;Health;Household;Hypertension;Immune;Impairment;in vivo;Individual;Intervention;Knowledge;Lactobacillaceae;Life;Link;Machine Learning;maternal separation;Measurement;Measures;Mediating;Mediation;Mediator;Mental disorders;Metabolic;metabolomics;metagenomic sequencing;microbial;mouse model;mRNA Expression;multiple omics;Mus;neglect;neonate;Neurologic;novel;offspring;Pathway interactions;pediatric trauma;Peripheral Resistance;Phase;Phenotype;Play;Production;Propionates;protein expression;Publishing;receptor;receptor expression;Recording of previous events;Research;Risk;Risk Factors;Rodent Model;Role;single-cell RNA sequencing;skills;stress reduction;Stressful Event;Superoxides;Supplementation;System;Techniques;Testing;Time-restricted feeding;Tissues;United States;Vascular Diseases;Volatile Fatty Acids;Woman

PROJECT_TITLE: Early Life Stress and Cardiovascular Disease Risk: Identifying the Role of Microbial Metabolites

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Valley Fever

ORG_CITY: INDIANAPOLIS

ORG_NAME: MIRAVISTA DIAGNOSTICS, LLC

ORG_STATE: IN

PHR: Narrative. Coccidioidomycosis is a significant source of morbidity, mortality and cost within endemic regions. Disease presentation can range from asymptomatic to life threatening disseminated disease in immunocompromised individuals. It is also estimated that between 15%- 30% of community acquired pneumonia is attributable to coccidioidomycosis within endemic regions. Those on immunosuppressive therapies, such as those receiving organ transplants, are at risk for severe Coccidioides infections. The development of an ex vivo cytokine release assay has several potential benefits to aid in the diagnosis, management and distribution of coccidioidomycosis. It could be used to test for previous infection in populations or in individuals. This use could help establish prevalence in geographic areas and determining the measures to take before beginning immunosuppressive therapy. The test could also have prognostic value, as development of a lasting cellular immune response has been associated with positive outcomes. The presence or absence of an adaptive cellular immune response and the ability to reliably monitor it will be critical to the development and monitoring of individuals that will receive a future coccidioidomycosis vaccine.

PI_NAMEs: HOLBROOK, ERIC  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Academic Medical Centers;Acute;acute infection;Antibodies;Antifungal Therapy;Antigens;Area;arid land;Arizona;Biological Assay;Blood specimen;care costs;Caring;Cell Survival;Cellular Immunity;Characteristics;climate change;Clinical;clinical care;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;community acquired pneumonia;cost;cytokine;Data;Dedications;Delayed Hypersensitivity;desert fever;Detection;detection assay;Development;Diagnosis;Diagnostic;diagnostic development;Diagnostic tests;Disease;Epidemiology;Evaluation;fungus;Future;Geographic Locations;geographic population;Goals;Grant;Health Care Costs;high risk;Hour;Hypersensitivity skin testing;Immune response;Immunity;Immunocompromised Host;immunological status;immunosuppressed;Immunosuppression;Incidence;Individual;Infection;Interferons;Laboratories;latent infection;Life;Marketing;Measures;Methods;Monitor;Morbidity - disease rate;mortality;North America;novel;novel diagnostics;Occupations;Organ Transplantation;Outcome;pathogen;Patient Care;Patients;Performance;Persons;Phase;Physicians;Population;post-market;predictive modeling;Predictive Value;Prevalence;Preventive;prognostic;prognostic value;prototype;Public Health;Reaction;Recombinants;recruit;response;Risk;risk mitigation;risk stratification;ROC Curve;screening;Screening procedure;Serodiagnoses;Serology test;Serum;Shipping;Solid;Source;South America;Specificity;Standardization;stem cells;Stratification;Stress;T-Lymphocyte;Temperature;Testing;Therapeutic immunosuppression;tool;Travel;Tuberculosis;United States;Universities;vaccine trial;Vaccines;Whole Blood

PROJECT_TITLE: Development of Coccidioides Cytokine Release Assay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative We previously showed that normal plasma cells and cancerous multiple myeloma (MM) cells, have abundant, inefficient immunoglobulin synthesis and impaired protein degradation, resulting in accumulation of polyubiquitinated proteins and proteotoxic stress. We recently discovered that critical depletion of ubiquitin, a small protein necessary for both protein degradation and DNA repair, occurs during B lymphocyte differentiation. We hypothesize that functional ubiquitin depletion during B cell differentiation is a novel cancer-causing mechanism by impairing DNA repair, paving the way for development of innovative therapies in MM and potentially other cancers.

PI_NAMEs: BIANCHI, GIADA  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acceleration;Apoptosis;Articulation;B cell differentiation;B lymphoid malignancy;B-Lymphocytes;Biological Markers;Biology;Bone Marrow;Cancer Biology;Cancerous;career;Cell Death;Cell Survival;Cells;Cellular biology;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Data;design;Development;Disease;DNA;DNA analysis;DNA Damage;DNA Repair;DNA Sequence Alteration;driver mutation;Educational workshop;experimental study;Generations;Genetic;Genomic Instability;Genomics;Goals;Heavy-Chain Immunoglobulins;Hematologic Neoplasms;Immunoglobulins;Impairment;innovation;Innovative Therapy;International;Investigation;knock-down;Knock-out;Knowledge;Life;Link;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;meetings;Mentors;Modeling;Molecular;molecular targeted therapies;Monoclonal gammopathy of uncertain significance;mouse model;multicatalytic endopeptidase complex;Multiple Myeloma;Mutation;novel;novel therapeutics;Nuclear;Oncogenic;Oncology;Outcome;Pathogenesis;Pathologic;Physiological;plasma cell differentiation;Plasma Cells;Precancerous Conditions;Proliferating;Protein Biosynthesis;protein degradation;Proteins;Proteomics;proteotoxicity;Public Health;Publishing;Research;Research Personnel;response;Rest;Secondary to;small hairpin RNA;Stress;Structure of germinal center of lymph node;Technology;Testing;Tetracyclines;Time;Transfection;Transgenic Mice;Tumor Suppressor Genes;UBC gene;Ubiquitin;Western Blotting;Western World;Work

PROJECT_TITLE: Functional Consequences of Ubiquitin Depletion During B Lymphocyte Differentiation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Recent exciting developments in psychiatry and neuroscience hold great promise for our understanding of the causes and treatments for mental illness. However, a critical shortage of physician-scientists limits our ability to advance this science and translate discoveries into effective prevention and treatment strategies. This application seeks to continue support for a psychiatry residency research training program that aims to increase the number of physician-scientists conducting innovative and rigorous research on the causes and treatment of psychiatric disorders.

PI_NAMEs: TYRKA, AUDREY  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Advisory Committees;Area;Award;Basic Science;Behavior;Benchmarking;Big Data;Biological Psychiatry;Brain;Caliber;career;career development;Clinical;clinical training;Collaborations;complex data;Computerized Medical Record;curriculum development;Data;Data Set;Dedications;design;Development;didactic education;Doctor of Philosophy;Education;education planning;Education Projects;education research;Educational Curriculum;Environment;Equilibrium;experience;Feedback;Fellowship;Fostering;Functional disorder;Funding;Genomics;Goals;Grant;hands on research;Human;improved;innovation;International;Journals;Leadership;Manuscripts;Mental disorders;Mentors;Mission;mobile computing;mobile sensor;Molecular;Monitor;multidisciplinary;National Institute of Mental Health;Needs Assessment;neuroimaging;Neurons;neurophysiology;Neurosciences;next generation;Outcome;Physicians;Physiology;posters;Prevention;Prevention strategy;Productivity;programs;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;Publishing;Qualifying;Readiness;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Residencies;response;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;skills;social media;Source;success;symposium;Talents;Time;tool;Training;Training and Education;Training Programs;Translating;Travel;treatment strategy;Underrepresented Minority;Universities;Work;Writing

PROJECT_TITLE: Promoting Research Training During Psychiatry Residency


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative of CARE 2.0 This project will implement CARE 2.0, an extension of the ongoing CARE (Collaborative Approach for Asian Americans, Native Hawaiians & Pacific Islanders (AANHPI) Research and Education) registry, launched in October 2020 to improve representation of AANHPI groups in Alzheimer’s Disease and Related Disorders (ADRD), aging, and caregiving research. As a critical next step, CARE 2.0 will 1) strategically expand the registry in the US with emphasis to increase enrollment of AANHPI groups underrepresented in CARE 1.0 and examine registry participants’ research attitudes in participation in health research; 2) examine and develop methods to improve registry retention; and 3) optimize CARE registry participants’ inclusion in ADRD, aging, and caregiving research and examine the factors associated with research enrollment decisions by registry participants. To our knowledge, CARE is the only US multi- lingual registry with a focus on supporting ADRD, aging, and caregiving related research for AANHPI populations and will be uniquely positioned to improve representation of AANHPI groups in research while also advancing the science of recruitment and retention.

PI_NAMEs: GRILL, JOSHUA ;PARK, VAN MY TA (contact);TSOH, JANICE Y

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Achievement;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Asian Americans;Asian Indian;Asian population;Attitude;Behavioral;Biological;Biological Markers;Blood;Budgets;Caregivers;caregiving;caregiving research;Clinical Research;Clinical Trials;cohort;collaborative approach;Communities;community based participatory approach;comparative;Data Analyses;Data Set;Databases;dementia caregiving;dementia risk;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Enrollment;Ensure;Equity;Ethnic Origin;experience;Filipino;Focus Groups;Funding;Hawaiian;Health;health disparity;Heterogeneity;Image;improved;Individual;innovation;interest;Japanese;Koreans;Language;Learning;Life Style Modification;Lightning;Limited English Proficiency;Methods;Modality;Multilingualism;Native Hawaiian;Native Hawaiian or Other Pacific Islander;older adult;Outcome;outreach;Pacific Islander;Participant;Pattern;Persons;Population;Positioning Attribute;Procedures;prospective;R24;racial population;Recommendation;recruit;recruitment science;Registries;Reporting;Research;Research Design;retention rate;Risk Factors;Samoan;Sampling;screening;secondary analysis;social culture;socioeconomics;Source;Structure;Subgroup;Testing;Therapeutic;tool;treatment research;Underrepresented Populations;United States;United States National Institutes of Health;Vietnamese;willingness

PROJECT_TITLE: Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will determine the strength and duration of the immune responses induced by the SARS-CoV-2 vaccination of people with HIV infection (PWH) and develop a model based on clinical parameters to predict the vaccine immune responses. Such information will help health care experts develop proper public health policy decisions for prevention of COVID-19 disease.

PI_NAMEs: MAILLIARD, ROBBIE B;RINALDO, CHARLES R (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: 2019-nCoV;Affect;Anti-Retroviral Agents;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Authorization documentation;B-Lymphocytes;Biological Markers;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cells;Chronic;Clinical;cohort;Cohort Studies;comorbidity;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 prevention;COVID-19 vaccination;COVID-19 vaccine;cytokine;cytotoxic;Data;Data Set;design;Disease;Exhibits;Female;Genetic Transcription;Health;Health Policy;Healthcare;Hepatitis B Vaccination;HIV;HIV Infections;IgG1;IgG3;Immune;Immune response;Immune System Diseases;Immunity;Immunization;Immunocompetent;immunodeficiency;immunogenicity;Immunologic Markers;Individual;Inflammation;Influenza vaccination;Interferon Type II;Investigation;Long-Term Effects;Longitudinal Studies;Machine Learning;male;Measles;Measurable;Memory B-Lymphocyte;men;Modeling;Moderna COVID-19 vaccine;multiple omics;Natural Killer Cells;neutralizing antibody;Outcome;Participant;pathogen;Performance;Persons;Pfizer-BioNTech COVID-19 vaccine;Phase;Phenotype;predictive marker;Prevention;Public Health;Recommendation;Resources;response;RNA vaccine;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;Secondary Immunization;seroconversion;Serology;South African;success;T-Cell Activation;T-Lymphocyte;TNF gene;treatment trial;United States;Vaccinated;Vaccination;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;vector-based vaccine;Viral Vector;Woman

PROJECT_TITLE: Immune response to COVID-19 vaccine in HIV infected men and women

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Genetics;Heart Disease;Kidney Disease;Lupus;Mental Health;Prevention;Social Determinants of Health

PHR: Project Narrative Childhood abuse and trauma (early life stress) impacts disease and health later in life by increasing risk for cardiovascular disease (CVD) and autoimmunity. Systemic Lupus Erythamateous (SLE), an autoimmune disease, has high CVD burden and poor outcomes in patients with ELS. This project will examine the potential cause for increased CVD risk in ELS by examining the observed prevalence of macrophages, an immune cell mediator of vascular maintenance, and by examining CVD risk markers in conjunction with mitochondrial derived superoxide in a model of SLE with or without ELS exposure.

PI_NAMEs: KELLUM, CAILIN  (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Animals;Antinuclear Antibodies;Aorta;Aortic Diseases;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Blood;Blood Vessels;Bone Marrow;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Career Choice;Cells;Child Abuse;childhood adversity;comparison control;constriction;cytokine;Data;design;Development;Diagnosis;Dichloromethylene Diphosphonate;Disease;DNA Damage;ds-DNA;early life stress;Encapsulated;endothelial dysfunction;Endothelium;experience;experimental study;Exposure to;Flow Cytometry;Functional disorder;Goals;Health;Heart Diseases;High Prevalence;Hospitalization;Household;Hypertension;Immune;immune activation;Immunity;Immunoglobulin G;Immunology;Impairment;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Injections;insight;interest;Intervention;Investigation;Kidney;Knowledge;Life;Link;Lipopolysaccharides;Liposomes;Lupus;Lupus Nephritis;Macrophage;Macrophage Colony-Stimulating Factor;Maintenance;maternal separation;Measures;Mediating;Mediator;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;monocyte;mortality;mouse model;Mus;novel;Outcome;Oxidative Stress;Pathway interactions;Patients;pediatric trauma;Peritoneal Macrophages;Phenotype;Play;Population;pre-clinical;Prevalence;prevent;Prevention strategy;Pristane;Production;Proliferating;Protocols documentation;Relaxation;Reporting;response;Risk;Risk Factors;Risk Marker;Rodent Model;Role;Saline;Scheme;Severities;Severity of illness;Sexual abuse;skills;Stimulus;Superoxides;Systemic Lupus Erythematosus;Telemetry;Testing;Training;Training Support;transcriptome sequencing;Tunica Adventitia;Vascular Diseases;Verbally abusive behavior;Weaning

PROJECT_TITLE: Early Life Stress Promotes an Inflammatory Phenotype Leading to Vascular Impairment and Lupus Nephritis Severity


ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE Uncontrolled inflammation, arising from abnormal anti-inflammatory T lymphocytes (T regulatory cells, Tregs), is implicated in a lethal cardiopulmonary condition called pulmonary arterial hypertension (PAH). This proposal seeks to understand how genetic risk factors and environmental triggers provoke Treg defects in PAH. By testing whether restoring Treg immunity reverses established PAH in experimental models, this proposal provides the foundational science to guide the design of a novel cell-based therapy for this devastating disease.

PI_NAMEs: NICOLLS, MARK ROBERT (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Abnormal Cell;Address;Adoptive Transfer;Affect;Alveolar;Amphiregulin;Animals;Anti-Inflammatory Agents;attenuation;Autoimmune;Autoimmune Diseases;Autoimmunity;Blood Vessels;BMP6 gene;BMPR2 gene;bone morphogenetic protein receptors;Cardiopulmonary;Cell Death;Cell Lineage;Cell Maturation;cell motility;Cell Physiology;Cell Proliferation;Cell Therapy;Cells;Characteristics;Chemotaxis;Chronic;Clinical;Clinical Research;clinical translation;Clinical Trials;Coculture Techniques;Critical Pathways;Cues;Data;Defect;design;Development;Disease;disease model;Disease susceptibility;efficacy testing;Endothelial Cells;Endothelium;Engineering;Epidermal Growth Factor;Estrogen Receptors;Exhibits;Experimental Models;Female;Flow Cytometry;Functional disorder;Future;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic variant;genome editing;Grant;Growth;healing;Health;Histologic;Histology;Home;Homeostasis;Human;Hypertrophy;Immune;Immune response;Immunity;Immunologics;immunoregulation;Immunotherapy;improved;Inflammation;Inflammatory;Infusion procedures;Inherited;Injections;Injury;Interleukin-2;Label;Location;Lung;lung injury;lung vascular injury;male;Mediating;migration;Modeling;Molecular;mutant;Mutation;Natural regeneration;novel;Nude Rats;Phenotype;Play;pre-clinical;preclinical study;Predisposing Factor;Predisposition;prevent;Proliferating;Prostaglandins I;protective effect;Proteins;Protocols documentation;Publishing;pulmonary arterial hypertension;Pulmonary Hypertension;Pulmonary Inflammation;pulmonary vascular disorder;Rat Transgene;Rattus;receptor;Recombinants;Regulation;Regulatory T-Lymphocyte;restoration;Risk Factors;Role;Science;sex;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;synthetic biology;System;T cell differentiation;T cell therapy;T-Cell Development;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;Therapeutic;thymocyte;Thymus Gland;tissue regeneration;Tissues;Titrations;transcriptome;Transposase;vascular inflammation;vascular injury;Vascular remodeling;virulence gene

PROJECT_TITLE: Regulatory T Cells and Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health

PHR: PROJECT NARRATIVE Most patients with common cancers in the United States receive surgical care within health systems, but quality is inconsistent across system hub and spoke sites. This project will evaluate the effect of treatment in a health system hub or spoke on receipt of evidence-based surgical cancer care and will identify health system characteristics and strategies that are associated with system performance and consistency across sites. The product, an intervention map for system-level implementation of oncologic evidence, can be used by health systems to provide consistent, high-quality care across sites, increasing equity in cancer care delivery.

PI_NAMEs: BROMAN, KRISTY KUMMEROW (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adopted;Adoption;advanced analytics;Alabama;analytical method;Attention;Award;biomedical referral center;cancer care;cancer health disparity;Cancer Patient;cancer risk;cancer surgery;cancer therapy;care coordination;care delivery;care outcomes;Caring;Characteristics;Clinical;common treatment;Complement;Complex;Consultations;cost;Cutaneous Melanoma;Data;Data Science;Decentralization;Deimplementation;design;Dissemination and Implementation;effective therapy;Ensure;Equity;evidence base;Evidence based practice;Future;Goals;health care availability;health care delivery;health care disparity;Health care facility;health care service organization;Health Services;Health system;Hospitals;implementation science;implementation strategy;Improve Access;improved;ineffective therapies;Integrated Health Care Systems;Intervention;intervention mapping;Interview;Investments;Joints;Knowledge;Level of Evidence;Link;Location;Logic;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;medical specialties;Medicare;Mission;Modeling;multilevel analysis;Needs Assessment;novel;Operative Surgical Procedures;outcome disparities;Ownership;Patient-Focused Outcomes;Patients;Penetration;Performance;Population;Process;programs;Provider;Quality of Care;remote location;Research;Research Methodology;Research Personnel;Resources;Rural;Rural Population;Science;secondary analysis;Site;Solid Neoplasm;Structure;surgical risk;System;Theoretical model;therapy design;Training;treatment effect;United States;United States National Institutes of Health;Universities;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Leveraging Health Systems to Increase Implementation of Evidence-based Surgical Cancer Care


ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: OVERALL - NARRATIVE This P01 will use cell specific targeting approaches and cutting edge in vivo assessment techniques in preclinical mouse models— validated by biomarker measures in human subjects— to unravel the role(s) of reactive astrocytes in the pathophysiology of Alzheimer’s disease and related dementias.

PI_NAMEs: NORRIS, CHRISTOPHER MARK (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: ABCC9 gene;Address;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;Animals;Area;Astrocytes;Attention;Autopsy;Awareness;Back;Biochemical Pathway;Biological Markers;Biology;biomarker validation;Biometry;Blood Vessels;Brain;Brain Pathology;Categories;Cells;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;Communities;Complex;Consultations;CRSP3 gene;Data Analyses;data integration;data management;data pipeline;Dementia;design;Disease;disease phenotype;Electroencephalography;Electrophysiology (science);Functional disorder;Future;Gene Expression Profiling;Glutamate Transporter;Glutamates;Goals;Grant;hippocampal sclerosis;Human;human data;human subject;Imaging Techniques;Impaired cognition;Impairment;in vivo;Insulin Receptor;insulin signaling;Intervention;intravital imaging;Kentucky;knock-down;Leadership;limbic-predominant age-related TDP-43 encephalopathy;Liquid substance;Magnetic Resonance Imaging;Measures;Metabolic;Microelectrodes;Microglia;MMP9 gene;Modeling;mouse model;Mus;neural network;neurochemistry;neuroinflammation;Neurons;novel therapeutic intervention;overexpression;Pathologic;Pathology;Phenotype;Physiological;pre-clinical;pre-clinical research;Property;Receptor Signaling;Recording of previous events;Renaissance;Research;Resources;risk variant;Role;Signal Transduction;Statistical Data Interpretation;Structure;Techniques;Technology;Testing;Therapeutic;Time;Tissues;two photon microscopy;United States National Institutes of Health;Universities;vascular cognitive impairment and dementia

PROJECT_TITLE: Strategies for targeting astrocyte reactivity in Alzheimer's disease and related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;animal colony;Animals;Astrocytes;Behavioral;Breeding;Budgets;cohesion;Collaborations;data sharing;Electrophysiology (science);Endowment;Ensure;Faculty;Feedback;Fostering;Functional disorder;Funding;Future;Genotype;Health;IACUC;Infrastructure;Leadership;Learning;Maintenance;meetings;Memory;mouse model;Neurons;Nutritional Science;Pharmacology;Production;professor;Progress Reports;Protocols documentation;Reagent;Recombinants;Research;Research Personnel;Resources;Role;Route;Science;Services;Signal Transduction;Source;success;symposium;United States National Institutes of Health;Universities;University adminstration;Update;vascular cognitive impairment and dementia;Viral;welfare;Work

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SOMPOL, PRADOLDEJ  (contact)

PROJECT_TERMS: Acute;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animals;Astrocytes;Biological Assay;Biological Markers;Biometry;Blood flow;Blood Vessels;Brain;brain cell;brain metabolism;Brain region;cell type;Cells;Cephalic;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Chronic;cohesion;Consultations;Craniotomy;cranium;Data;Data Analyses;Data Collection;data management;Dementia;Electrophysiology (science);Ensure;experience;experimental study;Faculty;Gene Delivery;Goals;Human;Human Pathology;Human Resources;Image;Image-Guided Surgery;imaging facilities;Imaging Techniques;Impairment;implantation;in vivo;Injections;intravital imaging;Kentucky;knock-down;Laser Speckle Imaging;Magnetic Resonance Imaging;Metabolic;Metabolism;Methods;Microelectrodes;Microscopy;molecular pathology;Monitor;mouse model;Mus;neural network;neurochemistry;neuroinflammation;Neurons;novel;Operative Surgical Procedures;patch clamp;Pathology;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Preparation;preservation;Procedures;Process;Property;Protocols documentation;Research;Resources;Role;Services;Signal Pathway;Signal Transduction;Slice;Students;success;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Thinness;Training;two-photon;Universities;Vibrissae;Work

PROJECT_TITLE: Core B - Animal Vascular-Metabolic-Neural Network Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: NELSON, PETER T. (contact)

PROJECT_TERMS: 3-Dimensional;ABCC9 gene;Address;alpha synuclein;Alzheimer's disease related dementia;Amyloid beta-Protein;Anatomy;arteriole;Astrocytes;Astrocytosis;Automobile Driving;Autopsy;biobank;Biochemical;Biochemistry;Biological Assay;Biological Markers;biomarker identification;Blood capillaries;blood oxygen level dependent;Blood Vessels;Brain;Brodmann's area;CD34 gene;Cerebrospinal Fluid;cerebrovascular reactivity;Clinical;clinical diagnosis;clinical material;clinical outcome measures;Clinical Research;clinically relevant;Complement;Complex;Consultations;CRSP3 gene;Data;Data Management Resources;data modeling;data streams;Dementia;Diagnosis;Documentation;endophenotype;Enzyme-Linked Immunosorbent Assay;Experimental Models;experimental study;Fostering;Freezing;frontal lobe;Funding;Genotype;Glial Fibrillary Acidic Protein;gray matter;Hippocampus;Human;human data;human imaging;human subject;Image;Immunofluorescence Immunologic;in vivo;Infrastructure;Insulin Receptor;Label;Liquid substance;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;meetings;Metabolic;Methods;MMP9 gene;Molecular;Morphology;mouse model;multimodal data;Mus;Neocortex;Neurofibrillary Tangles;neuroimaging;neuropathology;Neuropsychology;Participant;Phenotype;Plasma;pre-clinical;protein TDP-43;Proteins;Research;Research Design;Resources;risk variant;Running;Sampling;sarkosyl;Senile Plaques;specific biomarkers;Structure;Syndrome;synergism;tau Proteins;Testing;Therapeutic Intervention;Tissues;Translating;Translational Research;Translations;Triton X100;United States National Institutes of Health;Urea;Western Blotting;white matter;Work

PROJECT_TITLE: Core C - Human Consultation-Biosamples-Biomarkers Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Brandon

ORG_NAME: LEFLORE TECHNOLOGIES, LLC

ORG_STATE: MS

PHR: Narrative.  Chronic renovascular disease can deteriorate renal function leading to chronic kidney disease and the need for dialysis, and it increases the risk of heart attacks, strokes, and death. Current treatment for renovascular disease involving renal angioplasty and stenting combined with anti-angiotensin agents and statins are ineffective in up to half of the patients. The goal of this Phase II STTR is to extend efficacy and safety studies completed in Phase I using a biopolymer-stabilized vascular endothelial growth factor to recover the kidney microvascular density and function, including performing cGMP manufacturing; GLP toxicology in rats, minipigs, and beagles; and extended efficacy testing in multiple chronic kidney disease models of varying etiology.

PI_NAMEs: BIDWELL, GENE LEFLORE (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: 3-Dimensional;Adverse effects;Affect;Affinity;Aging;angiogenesis;Angioplasty;Angiotensins;Animals;Architecture;Binding;Biological;Biological Assay;Biological Availability;biomaterial compatibility;Biomedical Engineering;Biopolymers;Blood Vessels;Breast Cancer Model;Canis familiaris;cardiovascular risk factor;Cardiovascular system;Carrier Proteins;Cessation of life;Chemistry;Chimeric Proteins;Chronic;Chronic Kidney Failure;Clinical;clinically relevant;cohort;density;Deterioration;Diabetes Mellitus;Dialysis procedure;Diet;Disease;disease model;Dose;Drug Carriers;Dyslipidemias;efficacy study;efficacy testing;Elastin;End stage renal failure;Endothelium;Engineering;Etiology;Funding;Future;General Population;Glomerular Filtration Rate;Goals;good laboratory practice;Good Manufacturing Process;Growth;Growth Factor;Half-Life;Health Care Costs;Histologic;Hospitalization;hospitalization rates;Human;Hypertension;immunogenicity;improved;in vivo;Injury to Kidney;Kidney;Kidney Diseases;kidney vascular structure;Laboratories;Lead;Life Expectancy;Link;manufacture;Marketing;Maximum Tolerated Dose;Mediating;Microcirculation;Miniature Swine;Modeling;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;Nature;novel;novel therapeutics;patient population;Patients;peptide drug;Pharmaceutical Preparations;Pharmacology Study;Phase;phase 1 study;phase 2 study;Plasma;polypeptide;porcine model;pre-clinical;Preclinical Testing;preclinical trial;Predisposition;Prevalence;Process;Production;Proteins;Protocols documentation;Quality Control;Rattus;Recombinants;Recovery;renal artery;Renal Artery Stenosis;Renal Blood Flow;renal damage;Renal function;Renal Vascular Disorder;Research Contracts;residence;Resolution;response;Risk;Rodent;Rodent Model;Safety;safety study;Serious Adverse Event;Severity of illness;side effect;Small Business Technology Transfer Research;small molecule;Stents;Stroke;Technology;Testing;Therapeutic;therapeutic angiogenesis;therapeutic development;therapeutic protein;Time;Tissues;Toxicity Tests;Toxicology;treatment arm;Treatment Efficacy;Treatment Protocols;Tubular formation;tumor growth;United States;Validation;Vascular Endothelial Growth Factors;VEGFA gene;Work;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Renal Therapeutic Angiogenesis Using the Novel Biologic ELP-VEGF


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: KATSUMATA, YURIKO  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;Animals;Astrocytes;Binding;Bioinformatics;biomedical imaging;Biometry;Biostatistical Methods;Biostatistics Core;Communication;Complex;Computers;Data;Data Analyses;Data Collection;data format;data harmonization;data integration;data integrity;data management;data quality;data repository;data reuse;Data Security;Data Set;data standards;Data Storage and Retrieval;data visualization;data warehouse;Database Management Systems;Deposition;design;Directories;Discipline;Educational workshop;Electrophysiology (science);Ensure;experimental study;FAIR principles;Foundations;Goals;Graph;Human;Individual;Interdisciplinary Study;Language;large scale data;Linux;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Manuscripts;member;metabolomics;Metadata;Methodology;Methods;Microelectrodes;Mission;Modeling;multi-photon;multidisciplinary;Perception;Persons;Phase;Play;Practice Management;predictive modeling;Procedures;Proteomics;Pythons;Quality Control;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Resources;Role;Secure;Series;Services;Standardization;Statistical Data Interpretation;statistics;Structure;success;synergism;System;Technology;Time;Training;transcriptomics;Writing

PROJECT_TITLE: Core D - Data Management and Statistics Core


PI_NAMEs: WILCOCK, DONNA M (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;aquaporin 4;arm;Astrocytes;Autopsy;awake;Basement membrane;Biochemical;Biological Markers;Blood Vessels;Brain;Brain region;candidate identification;candidate marker;Cerebral small vessel disease;Cerebrovascular Disorders;cerebrovascular reactivity;Collaborations;comorbidity;Complex;cytokine;Data;Dementia;digital;Dissociation;Dystroglycan;Dystrophin;Electrophysiology (science);Euthanasia;Gene Expression;Gene Expression Profile;Glutamate Transporter;Harvest;Hemorrhage;Histologic;Human;human tissue;Hyperhomocysteinemia;Image;Impaired cognition;Impairment;in vivo;Inflammatory;Insulin;Lasers;Magnetic Resonance Imaging;Matrix Metalloproteinases;Measurement;Measures;Mediating;Metabolic;Microelectrodes;Microscopy;MMP9 gene;Monocarboxylic Acid Transporters;mouse model;multimodality;Mus;Nerve Degeneration;Neuronal Dysfunction;Neurons;neurovascular coupling;novel;object recognition;Outcome Measure;overexpression;Pathology;Perfusion;Plasma;Potassium Channel;Predisposition;protein expression;Proteins;Radial;Regulation;Slice;syntrophin;Testing;Time;two-photon;vascular cognitive impairment and dementia;vascular injury;Water;water channel;water maze;Wild Type Mouse;Work

PROJECT_TITLE: Project 1 - Astrocytic end-feet and VCID


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Biotechnology;Endocrine Disruptors;Foodborne Illness;Genetics;Health Effects of Indoor Air Pollution;Human Genome;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Prenatal exposures to inorganic arsenic have been shown to modulate offspring lung function, but less is known about how early-life exposure to arsenic promotes respiratory diseases like asthma. This research will examine the effect of maternal arsenic exposures on placenta function and offspring lung development over the adult life course. The completion of this research will allow the field for a better understanding of the impact of environmental arsenic exposure on women and children’s health, that inform strategies to prevent or reduce adverse respiratory health in affected communities.

PI_NAMEs: TANG, WAN-YEE  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adult;adverse pregnancy outcome;Affect;airway hyperresponsiveness;Allergens;Allergic;allergic airway disease;Animal Model;Arsenic;Asthma;asthma model;Attenuated;bisulfite sequencing;Cells;Child;Child Development;Child Health;Communities;comparison control;Coupled;Decidua Basalis;Development;Disease susceptibility;DNA Methylation;Documentation;drinking water;early childhood;Early Intervention;early life exposure;Embryo;Environmental Impact;environmental stressor;epidemiology study;Epigenetic Process;epigenetic regulation;epigenomics;Exposure to;fetal;Fetal health;Fetal Lung;Food;Functional disorder;Generations;Genetic Transcription;Genome;Germ Cells;global health;Growth;Guidelines;Health;House Dust Mite Allergens;Human;Hypersensitivity;Immunologic Sensitization;improved;Individual;indoor allergen;Inflammation;Inflammatory Response;Inherited;insight;Intervention;Laboratory Study;laser capture microdissection;late life;Leukocytes;Life;Life Cycle Stages;Link;Lung;lung development;Maternal Exposure;Maternal Health;Measures;Mediating;Mediator;Messenger RNA;methylation pattern;methylome;MicroRNAs;Modification;Molecular;Mus;neonate;novel;offspring;Outcome;Oxidative Stress;Pathogenicity;Pathologic;Phenotype;Physiological;Placenta;Placentation;postnatal;Predisposition;Pregnancy;prenatal exposure;prevent;Production;programs;pulmonary function;Pulmonary Inflammation;Pyroglyphidae;Reactive Oxygen Species;Reporting;Research;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;Risk;Role;Safety;single nucleus RNA-sequencing;Stress;Structure;Testing;transcriptome sequencing;Woman;Work

PROJECT_TITLE: Impact of Maternal Arsenic Exposure on Offspring's Epigenetic Reprogramming of Allergic Airway Disease

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Diabetes;Neurodegenerative;Neurosciences

PI_NAMEs: THIBAULT, OLIVIER  (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;Age;aged;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;amyloid pathology;amyloidogenesis;arm;Astrocytes;Attention;Autopsy;Behavior;Bioenergetics;Biological;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;brain dysfunction;brain metabolism;cell type;Cells;cellular targeting;cerebrovascular;Classification;Clinic;Clinical;Cognition;cognitive function;Collaborations;Coupled;Coupling;Data;data management;Data Set;density;Disease;Electroencephalography;Electrophysiology (science);Elements;Environment;Erythrocytes;experience;experimental study;Female;Frequencies;Future;Gene Expression Regulation;Glial Fibrillary Acidic Protein;Glucose;glucose sensor;Glucose Transporter;glucose uptake;Goals;Head;Health;Hippocampus;Human;Image;Impairment;In Situ;in vivo;Injections;Insulin;Insulin deficiency;Insulin Receptor;insulin signaling;Intention;Investigation;knock-down;Knockout Mice;Knowledge;large datasets;Leadership;Learning;lens;Magnetic Resonance Spectroscopy;male;Measures;memory process;Metabolic;Metabolism;Microscopy;Modeling;mouse model;multi-electrode arrays;Mus;Nerve Degeneration;Neurons;neurovascular unit;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;overexpression;Pathway interactions;Physiology;Play;promoter;Protocols documentation;Radial;Receptor Signaling;Reporting;Resolution;Resource Sharing;Rest;rhodamine dextran;Rodent;Role;Sampling;Series;sex;Signal Transduction;Site;Slice;Somatosensory Cortex;Specimen;Surface;targeted treatment;tau Proteins;Testing;therapeutic target;Time;Translating;two-photon;vector;water maze;Work

PROJECT_TITLE: Project 2 - Astrocytic insulin signaling and AD