ADMINISTERING_IC: DE

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Narrative Sjögren’s syndrome (SS), a chronic inflammatory autoimmune disease that affects ~ 4 million Americans, particularly women, is characterized by hyposalivation and dacryoadenitis with lymphocytic infiltration of salivary and lacrimal glands. Our research focuses on the cell surface receptors, P2X7 and P2Y2, for extracellular ATP, the chemical form of energy in a cell that when released from injured or diseased salivary and lacrimal gland tissue causes inflammation. The overall goal of these studies is to evaluate whether antagonism of the P2X7R and/or P2Y2R can protect the salivary and lacrimal glands from tissue damage in SS patients by investigating these novel signaling pathways in mouse models of SS.

PI_NAMEs: WEISMAN, GARY ANDREW (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Affect;Agonist;American;antagonist;Apoptosis;Archives;Artificial Saliva;Artificial Tears;Autoantibodies;Autoimmune Diseases;autoimmune exocrinopathy;Autoimmunity;Autologous;Bacterial Infections;Biopsy;Cadaver;cancer surgery;CD28 gene;cell injury;cell motility;Cell Separation;Cell surface;Cell Surface Receptors;Cells;Chemicals;Chronic;Clinical Trials;Coupled;Crohn's disease;cytokine;Dental caries;Deterioration;Development;Digestive System Disorders;Disease;Drainage procedure;Drops;Dry Eye Syndromes;Epithelial Cells;Epithelium;Exhibits;extracellular;eye dryness;Female;Fibrosis;Film;Fluids and Secretions;Functional disorder;Goals;GTP-Binding Proteins;Human;Hydration status;IL18 gene;Immune;Immune response;Immunomodulators;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;injured;innovation;Interferon Type II;Interleukin-1 beta;Interleukins;Ion Channel Gating;Knock-out;Lacrimal gland structure;Lupus;Lymphocyte;Lymphocytic Infiltrate;Lymphoma;Mediating;Minor;Minor salivary gland structure;mouse model;Mus;Muscarinic Acetylcholine Receptor;novel;Nucleotides;ocular pain;Ocular Pathology;ocular surface;Oral Pathology;P2Y2 receptor;Pathogenesis;Patients;Periodontitis;Phase;Play;preservation;prevent;Process;Production;Productivity;Proliferating;Quality of life;receptor;Receptor Activation;receptor expression;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Research;Residual state;Rheumatoid Arthritis;Role;Saliva;saliva secretion;Salivary Gland Diseases;Salivary Glands;Secondary to;Serum;Sialadenitis;Signal Pathway;Site;Sjogren's Syndrome;spatiotemporal;Submandibular gland;symptom management;Systemic Lupus Erythematosus;Testing;Throat Cancer;tissue degeneration;Tissues;Transgenic Organisms;Vision;Woman;Work;Xerophthalmia;Xerostomia;yeast infection

PROJECT_TITLE: Targeting P2 Receptors to Restore Salivary and Lacrimal Gland Function in Sjogren's Syndrome

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Many deaf children do not acquire age-appropriate spoken language even when they receive cochlear implants at early ages and have no other cognitive disabilities. This project investigates the real-time mechanisms of parent-child social interactions in deaf children with cochlear implants and how these interactions facilitate (or hinder) word learning and language outcomes. Because social interactions may be malleable, the knowledge gained from this project could lead to the development of novel intervention studies aimed at enhancing language development in deaf children who receive cochlear implants.

PI_NAMEs: HOUSTON, DEREK M (contact);YU, CHEN

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 5 year old;Accounting;Affect;Age;Attention;Auditory;Auditory Perception;auditory processing;Behavior;Child;Child Behavior;Child Rearing;Childhood;Chronology;Cochlear implant procedure;Cochlear Implants;cognitive disability;Collaborations;congenital deafness;Data;data streams;deaf;Development;Event;experience;Eye;Feedback;gaze;Hand;Head;implantation;infancy;insight;Intervention Studies;Joints;Knowledge;Language;Language Development;language outcome;Learning;learning outcome;Link;Matched Group;Measures;Mediating;Methods;Movement;multimodality;Names;normal hearing;novel;Parent-Child Relations;Parents;Participant;Pathway interactions;peer;Play;programs;Property;Research;Resolution;Risk Factors;Role;sensory input;Shapes;social;Social Interaction;social structure;sound;Speech Perception;System;Testing;Time;word learning;Work

PROJECT_TITLE: Parent-child interactions and word learning in young deaf children with cochlear implants


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer that is often driven by oncogenic alterations that are either not suitable for direct targeting or treatment resistance inevitably occurs. Squalene epoxidase (SQLE), an enzyme that controls cholesterol biosynthesis, is frequently overexpressed in NSCLC and is associated with poor prognosis. The goal of our application is to develop innovative strategies of combining SQLE and ATR/CHK1 inhibition to treat NSCLC, particularly against high-SQLE expressing subsets.

PI_NAMEs: ZHANG, JUNRAN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Affect;anti-cancer research;anti-fungal agents;antitumor effect;ataxia telangiectasia mutated protein;ATM function;Biological;biological adaptation to stress;Biological Assay;Ca(2+)-Calmodulin Dependent Protein Kinase;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer therapy;Cell Death;cell growth;Cell Line;Cell Survival;Cells;Cessation of life;CHEK1 gene;Cholesterol;cholesterol biosynthesis;cholesterol control;Cholesterol Homeostasis;Clinical;Clinical Trials;Complex;CRISPR/Cas technology;Cytogenetic Analysis;Data;Defect;Disease;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA Repair;DNA Repair Disorder;DNA replication fork;Drug Targeting;efficacy evaluation;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;epoxidase;Event;FDA approved;Fura-2;genome-wide;Goals;homologous recombination;Human;Immunotherapy;Impairment;improved;In Vitro;in vitro Assay;inhibitor;innovation;Interruption;knock-down;Lead;live cell imaging;loss of function;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;men;mouse model;Movement;multimodality;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;Oncogenic;overexpression;Pathway interactions;patient derived xenograft model;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;prevent;Prognosis;protein expression;Proteins;ratiometric;repaired;replication stress;Reporter;Reporting;response;Role;screening;Signal Transduction;small hairpin RNA;Squalene;synergism;synthetic lethal interaction;targeted treatment;Techniques;Testing;therapy resistant;treatment strategy;tumor growth;Woman

PROJECT_TITLE: Targeting cholesterol metabolism and replication stress response in cancer therapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: NARRATIVE PRPH2-associated disease phenotypes are complex and multifactorial, involving not just photoreceptors, as has historically been reasoned, but also secondary effects on the retinal pigment epithelium and retinal/choroidal vasculature. Understanding the mechanisms of these complicated disease phenotypes is absolutely critical for the development of treatments and for our understanding of disease mechanisms associated with other genes in which the primary defect is in photoreceptors but the disease phenotype affects multiple tissues. These studies use novel mouse models to directly address these issues in unique ways that are innovative and highly suited to our expertise and tools.

PI_NAMEs: AL-UBAIDI, MUAYYAD R;NAASH, MUNA I. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Animal Model;Apoptosis;Atrophic;Binding;Binding Sites;Biochemical;Biological;Biology;Blindness;Bypass;Cells;Cellular biology;Characteristics;Choroid;Choroidal Neovascularization;Clinical;clinical phenotype;combat;Complex;conditional knockout;Cone;cone-rod dystrophy;Data;Defect;Development;Disease;disease model;disease phenotype;disease-causing mutation;Dominant-Negative Mutation;Dose;effective therapy;Event;Exhibits;Funding;Fundus;gain of function;Generations;Genes;Genotype;Goals;Golgi Apparatus;Grant;Health;Heterogeneity;Image;Immune response;inherited retinal degeneration;innovation;Knock-in;Knock-in Mouse;Knowledge;Lead;Learning;Link;macula;Macular degeneration;Membrane Proteins;Methods;Modeling;Molecular;mouse model;Mutation;neovascularization;Neural Retina;novel;Organ;Outcome;Outcome Study;Oxidative Stress;Pathogenicity;Pathology;Pathway interactions;Patients;pattern dystrophies;peripherin;Phenotype;Photoreceptors;Play;Process;Property;Proteins;Proteomics;research clinical testing;Research Personnel;Resolution;Retina;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Rod;Rod Outer Segments;Role;Secondary to;Severities;skills;SNAP receptor;Structural defect;Structure;Structure of retinal pigment epithelium;syntaxin;targeted treatment;Technology;Therapeutic;therapeutic development;therapy development;Time;Tissues;tool;Toxic effect;trafficking;Vertebrate Photoreceptors;Work

PROJECT_TITLE: Mechanism of photoreceptor cell degeneration in animal models of retinal diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Anxiety disorders are the most common form of mental illness, can be highly impairing, and behaviors and brain changes that are precursors of anxiety disorders might start as early as birth. The goal of this study is to measure brain activity in newborn infants in response to sudden unexpected noises and test whether this brain activity predicts which infants are likely to develop problems with anxiety later in life. The results of this study are likely to assist in the early identification of children who might develop problems with anxiety and could lead to the design of interventions that lower the risk for developing anxiety.

PI_NAMEs: SYLVESTER, CHAD MICHAEL (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Address;Adult;Affect;Age;Anxiety;Anxiety Disorders;anxiety states;Attention;auditory stimulus;Behavior;behavior measurement;Behavioral;Behavioral inhibition;Birth;Brain;brain abnormalities;brain based;brain circuitry;Brain region;Child;Childhood;Coupled;Data;Development;early childhood;Early identification;Electroencephalography;Environment;Equipment and supply inventories;Exposure to;Familiarity;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Grant;high risk;high risk infant;Impairment;infancy;Infant;infant temperament;Knowledge;Life;Link;Magnetic Resonance Imaging;maternal anxiety;Measures;Mediating;Mental disorders;Mothers;Neonatal;neonatal brain;neonatal period;neonate;neural;Newborn Infant;Noise;novel;offspring;Pathway interactions;Pregnancy;Pregnant Women;prenatal;prevent;Prevention;preventive intervention;Preventive measure;Process;Public Health;Questionnaires;Reaction;recruit;response;Rest;Risk;risk prediction;Signal Transduction;Sleep;Stimulus;System;Temperament;Testing;therapy design;therapy development;Third Pregnancy Trimester;trait;treatment of anxiety disorders;Visit;Youth

PROJECT_TITLE: Neonatal Brain Activity and Risk for Anxiety Disorders in Early Childhood


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Transgender and nonbinary people continue to face incredibly high rates of mental health concerns, due largely to minority stress and discrimination, as well as inadequate access to affirming mental health services at most major hospitals in the United States. By assessing a large database of almost 10,000 transgender adults in the Bronx, NY, this study will explore disparities between transgender and non-transgender people’s access to quality mental health care, and will incorporate conextual information from in-depth interviews with transgender patients and affirming providers. This research will contribute to our fundamental understanding of ways healthcare systems reinforce mental health care disparities for transgender and nonbinary people, and will generate solutions to improve access to quality, affirming services at any site.

PI_NAMEs: BRESLOW, AARON S (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Administrator;Adult;advanced system;Advocate;Award;Behavioral;behavioral health;care delivery;care outcomes;Caring;Characteristics;cisgender;Clinic;Clinical Data;Clinical Skills;cohort;Collaborations;Congresses;contextual factors;Data;Data Analyses;data integration;Databases;Discrimination;Disparity;disparity reduction;Electronic Health Record;Exclusion;Exhibits;Face;Future;gender minority stress;Goals;Health;health care delivery;health care disparity;health care service;Health Personnel;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;Hospitals;Improve Access;improved;improved outcome;Individual;Inequity;innovation;insurance claims;Intervention;intervention mapping;Interview;Investigation;Learning;Life;Maps;Measures;Medical;Medical center;medically necessary care;Mental disorders;Mental Health;Mental Health Services;Methods;minority stress;National Institute of Mental Health;New York City;nonbinary;novel;Outcome;outreach;Patients;Persons;Policies;Politics;Population;Population Heterogeneity;Procedures;Provider;Psychological Stress;Reporting;Research;Research Personnel;resilience;Resources;Risk;Sampling;scale up;Service delivery model;Services;Site;social;social determinants;social health determinants;Strategic Planning;Suicide attempt;Surveys;System;Time;Training;transgender;United States;Visit

PROJECT_TITLE: Mapping Interventions to Reduce Mental Health Services Disparities among Transgender and Nonbinary Adults


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Fatty liver disease is closely associated with obesity and type-2 diabetes but without available effective drug therapies. This study investigates the mechanisms of Cullin-RING E3 ligases regulation of hepatic nutrient signaling and glucose and lipid metabolism in mouse models of obesity and fatty liver disease. In addition, this study will use pharmacological approaches to study if Cullin-RING E3 ligases can serve as potential therapeutic targets for treating lipid and glucose dysregulation in fatty liver disease and type-2 diabetes.

PI_NAMEs: LI, TIANGANG  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Affect;anti-cancer research;Attention;Attenuated;Body System;cancer therapy;Carbohydrates;Catalytic Domain;Cellular biology;Chronic;clinical application;Complex;constitutive expression;Cullin Proteins;Data;design;Development;Diabetes Mellitus;Disease;drug development;Drug Targeting;Dyslipidemias;Enzymes;Extrahepatic;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;fatty liver disease;Fructose;Functional disorder;Future;Gene Delivery;Genetic;Gluconeogenesis;Glucose;Glucose Clamp;glucose metabolism;Goals;Health;Hepatic;Hepatocyte;Homeostasis;Human;Hyperglycemia;Hyperinsulinism;Hypoglycemic Agents;Impairment;improved;In Vitro;in vivo;Individual;Inflammatory Response;inhibitor;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Knockout Mice;Knowledge;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver metabolism;Lysine;Mammalian Cell;Mediating;Metabolic;metabolic phenotype;Metabolism;Modeling;Molecular Biology;Molecular Target;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nutrient;Obese Mice;Obesity;Oncogenes;Pathogenicity;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phase;prevent;Process;Proteins;Proteomics;Publishing;receptor;recruit;Regulation;Research;Role;scaffold;Signal Transduction;Specificity;Techniques;Testing;Therapeutic;therapeutic target;Tissues;transcriptomics;Tumor Suppressor Proteins;ubiquitin ligase;Ubiquitin Like Proteins;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Novel Roles of Cullin-RING E3 Ligases in Liver Pathophysiology

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH STATEMENT This study on the role of Shear Stress and Endothelial Pathophysiology in Intracranial Atherosclerosis uses neuroimaging tests routinely performed in patients with symptomatic intracranial atherosclerosis to develop new insight on how mechanical forces on the vessel wall are associated with cellular changes that promote inflammation and clotting that may lead to stroke. These imaging and biological markers may create a new way to prevent such strokes, a leading cause of death and adult disability worldwide. These collaborative efforts that combine unique and established expertise are urgently needed to address the lack of proven invasive or noninvasive imaging tools or treatments for intracranial atherosclerosis and the unmet risk of recurrent stroke.

PI_NAMEs: HINMAN, JASON D;LIEBESKIND, DAVID SIGMUND (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adult;Affect;Anatomy;Angiography;Anti-Inflammatory Agents;arterial lesion;Arteries;atherogenesis;Atherosclerosis;Biological;Biological Assay;Biological Markers;Biology;Blood Vessels;Cause of Death;Cellular Morphology;cerebrovascular;Cerebrovascular Circulation;Clinical;Clinical Data;clinically relevant;Coagulation Process;Collaborations;Contralateral;Coupled;Data;data archive;Data Set;Diagnosis;Diagnostic Imaging;disability;Elements;Endothelium;Ethnic Population;experience;experimental study;Functional disorder;Future;Goals;Hazard Models;high risk;Image;image archival system;imaging biomarker;Imaging Device;Individual;Inflammation;Inflammatory;Influentials;innovation;insight;Intervention;Intracranial Atherosclerotic Disease;Ipsilateral;Ischemic Stroke;Knowledge;Leadership;Lesion;Link;Liquid substance;Maps;Measurement;Measures;mechanical force;Microscopy;Minority;Modeling;Morphology;neuroimaging;Neurological outcome;neurovascular;non-invasive imaging;novel;novel strategies;Outcome;particle;Patients;Physiology;Platelet aggregation;precision medicine;prevent;prospective;Public Health;Recurrence;Research;Risk;Role;scaffold;shear stress;Site;Source;Stroke;stroke risk;Testing;Therapeutic;therapeutic target;Thrombosis;thrombotic;Time;tool;translational therapeutics;trial enrollment;Vascular Cell Adhesion Molecule-1;Velocimetries;Work

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative: Surprising or startling events activate the locus coeruleus, a region of the brain that controls arousal and is thought to aid subsequent perception and discrimination through modulation of sensory processing in the cortex. This modulation of the cortex is normally beneficial, but it can become dysregulated in disorders such as insomnia, depression, anxiety, and post-traumatic stress disorder. By exploring the mechanisms through which arousal shapes sensory processing, we hope to better understand the normal and pathological roles of arousal and highlight novel targets for therapeutic interventions.

PI_NAMEs: JENKS, KYLE ROBERT (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Air;Animals;Anxiety;Arousal;Aversive Stimulus;Axon;Behavior;Behavioral;Brain;brain control;Brain region;Calcium;career;Computer Analysis;Contrast Sensitivity;Coupled;Data;Discrimination;discrimination task;Disease;Disinhibition;Electrophysiology (science);Environment;Equilibrium;Event;excitatory neuron;Fire - disasters;Future;Goals;Image;improved;inhibitory neuron;Lead;Learning;Link;locus ceruleus structure;Measures;Mediating;Mediator;Mental Depression;Modeling;Mus;Mydriasis;neuronal circuitry;neuronal patterning;Neurons;neuroregulation;new therapeutic target;next generation;Norepinephrine;optogenetics;Pathologic;Pattern;Perception;Performance;Physiological;Population;Post-Traumatic Stress Disorders;Process;Punishment;Research;Research Personnel;Research Project Grants;response;Rewards;Role;sensor;Sensory;sensory cortex;sensory discrimination;sensory input;Shapes;Signal Transduction;Sleeplessness;spatiotemporal;Stimulus;Study models;Techniques;Technology;Testing;Therapeutic Intervention;Training;two-photon;Vasoactive Intestinal Peptide;Visual Cortex;visual discrimination;visual information;visual learning;visual processing;visual stimulus;Water

PROJECT_TITLE: Visual cortex circuits mediating arousal and visual discrimination


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Cherenkov imaging of radiation therapy delivery allows a real time visual mapping of the surface radiation deposited by the beam in the patients tissue. Developments to use this signal quantitatively as a dose imaging tool are developed in this work, for applications in external beam radiotherapy.

PI_NAMEs: GLADSTONE, DAVID J.;JARVIS, LESLEY A;POGUE, BRIAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Accreditation;Advanced Development;animation;Archives;Area;base;Breast;Calibration;cherenkov imaging;Chronic;Clinical;Clinical Management;clinically relevant;commercialization;Complex;Core Grant;Data;Deposition;design;Development;Doctor of Philosophy;Dose;Dose Rate;dosimetry;Electrons;Embryo;Engineering;experience;Fatty acid glycerol esters;Funding;Geometry;Grant;Human;human imaging;human tissue;Image;Image Analysis;Imaging Device;imaging facilities;imaging system;Imaging technology;improved;innovation;Institution;Leadership;Legal patent;Light;Linear Accelerator Radiotherapy Systems;Maps;Medical;Medicine;Methodology;Methods;Noise;Norris Cotton Cancer Center;oncology program;optical imaging;Optics;Patient imaging;Patients;Physics;Physiologic pulse;Positioning Attribute;programs;Property;Protons;Publications;quantitative imaging;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;real-time images;Recording of previous events;Research;Research Project Grants;Resources;Role;Scanning;Schools;Science;Shapes;Signal Transduction;Skin;skin color;Somatotype;success;Surface;System;Techniques;Technology;technology development;technology platform;Testing;Therapeutic;Time;timeline;Tissues;tool;treatment center;treatment planning;Visual;visual map;Visualization;Work

PROJECT_TITLE: OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/LAY SUMMARY Poor intratumoral infiltration of adoptively transferred T cells is a critical barrier to clinical success in solid tumors. A unique genetic screen approach identified Adapter Protein 2 Associated Kinase 1 (AAK1) as a key regulator of T cell infiltration. A better understanding of the relationship between AAK1 and T cell migration will determine the therapeutic potential of targeting AAK1 in cancer immunotherapy, including CAR-T.

PI_NAMEs: ROGERS, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adaptor Signaling Protein;Adoptive Cell Transfers;Adoptive Transfer;B lymphoid malignancy;Binding;Biochemical;cancer immunotherapy;cell motility;Cell Signaling Process;Cell surface;Cells;chemokine;chemokine receptor;Chemotaxis;chimeric antigen receptor;chimeric antigen receptor T cells;Clathrin;Clinical;CXC chemokine receptor 3;CXCL10 gene;CXCR3 gene;cytotoxic;Data;design;Development;Dominant-Negative Mutation;Endocytic Vesicle;Endocytosis;Engineering;enhancer-binding protein AP-2;Evaluation;experimental study;Flow Cytometry;Gene Modified;Gene Mutation;Genes;Genetic;Genetic Screening;genome wide screen;Goals;Hela Cells;Human;Image;immune checkpoint;improved;In Vitro;in vivo;Individual;Infiltration;innovation;Knock-out;Knockout Mice;Ligands;Malignant Neoplasms;Measures;Mediating;Melanoma;Microscopy;migration;Modeling;Modification;Molecular;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;overexpression;pharmacologic;Phosphotransferases;Play;pre-clinical;Process;Proteins;receptor;receptor expression;Receptor Signaling;Regulation;Regulatory Pathway;Reporting;Role;Series;Sleeping Beauty;Solid Neoplasm;standard care;success;Surface;System;T cell infiltration;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;trafficking;translational potential;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor microenvironment;Xenograft procedure

PROJECT_TITLE: Aak1 to increase infiltration of adoptively transferred cells into solid tumors

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Genetic variants in the gene CRX can cause inherited retinal diseases that lead to vision loss and blindness, but many CRX genetic variants are uncharacterized. This proposal aims to apply Deep Mutational Scanning, a new technique for studying many genetic variants at the same time, to comprehensively identify genetic variants in CRX that cause disease. This work will produce a “look-up table” listing all possible variants in CRX by their functional activity and propensity to cause disease, and will be directly applicable to the diagnosis of patients with diseases caused by mutations of CRX.

PI_NAMEs: SHEPHERDSON, JAMES LEWIS (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Age of Onset;Benign;Biological Assay;Blindness;Catalogs;Cells;Classification;Clinical;Clinical Management;Clinical Research;clinical sequencing;ClinVar;cone-rod dystrophy;Databases;Decision Making;Defect;Diagnosis;Disease;experimental study;gene-targeted therapy;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genotype;Homeobox;Human;human disease;Human Genetics;Inherited;interest;Leber's amaurosis;Libraries;Location;loss of function;Measures;Molecular;multiplex assay;Mutation;mutation screening;Pathogenesis;Pathogenicity;patient variability;Patients;Phenotype;Photoreceptors;Proteins;recessive genetic trait;Reporter;Reporter Genes;Reporting;Retina;Retinal Diseases;Retinitis Pigmentosa;Severities;System;Techniques;Technology;Testing;Time;transcription factor;Translating;United States National Institutes of Health;Variant;variant of unknown significance;Vertebrate Photoreceptors;Vision;Work

PROJECT_TITLE: Multiplex functional assay of variant effect in the retinal transcription factor CRX

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Infertility;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative  Age-related conditions are among the most devastating and agonizing diseases worldwide, with age- related declines in fertility being among the earliest and most frequent of these conditions. My proposed research studies the mechanisms by which aging damages the germline of the planarian S. mediterranea, and determines how regeneration reverses this damage and restores the flatworms to youthful levels of fecundity. This research will help us understand why humans and other organisms are unable to reverse germline aging, and could lay the groundwork for new treatments that preserve and restore fertility even into advanced age.

PI_NAMEs: VERDESCA, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Affect;Age;age related;age related biomarkers;age related decline;age-related disease;aged;Aging;aging biomarker;aging reversal;asexual;Assisted Reproductive Technology;Biological Assay;Biological Models;capsule;Cell Differentiation process;cell regeneration;Cells;common symptom;cost;Couples;Data;Defect;Disease;Educational process of instructing;Elderly;Epigenetic Process;Exhibits;experience;experimental study;Female;female reproductive system;Fertility;fertility preservation;Fluorescent in Situ Hybridization;Gametogenesis;Genetic Markers;Germ;Germ Cells;Germ Lines;Goals;Gonadal structure;hallmarks of aging;Health Expenditures;Healthcare Systems;Hermaphroditism;Human;Impairment;improved;in vivo;Infertility;infertility treatment;insight;Learning;Life;life span;Literature;male;men;mitochondrial dysfunction;model organism;Molecular;molecular marker;Morbidity - disease rate;mortality;Natural Fertility;Natural regeneration;offspring;Oligospermia;Organism;Output;Ovarian;Ovary;overpopulation;Partner in relationship;pathological aging;Patient-Focused Outcomes;Phenotype;Physiological;Pilot Projects;Planarians;Platyhelminths;Play;Population;precursor cell;preservation;prevent;Process;Production;proteostasis;regenerative;Regenerative capacity;Rejuvenation;reproductive;Reproductive Process;reproductive senescence;Research;research study;Resistance;Role;senescence;single-cell RNA sequencing;Spermatids;Spermatogonia;Testis;Time;United States;Woman

PROJECT_TITLE: Reversal of Age-Associated Damage in the Planarian Germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Many bacteria are causal pathogens for infectious diseases with strong abilities to develop drug resistance, bypass immune system and adapt to different host environments, while other commensal bacteria play important roles at the interface of host metabolism and the immune system. We aim to develop methods that enable the multiscale mapping, functional characterization and exploitation of bacterial DNA methylation towards the discovery of novel mechanisms in individual bacteria and the mammalian gut microbiome.

PI_NAMEs: FANG, GANG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Adenine;Antibiotic Resistance;Bacteria;Bacterial DNA;Basic Science;Biological;Bypass;Cell Cycle Regulation;commensal bacteria;Communicable Diseases;Communities;Cytosine;Defense Mechanisms;Development;DNA Methylation;DNA Restriction-Modification Enzymes;drug resistance development;Environment;Epigenetic Process;epigenetic regulation;epigenome;Event;Gene Expression;Genome;Goals;gut microbiome;Heterogeneity;host-microbe interactions;Immune system;improved;Individual;innovation;insight;Invaded;Maps;Metabolism;Methods;Methylation;methylome;Microbial Biofilms;Microbiology;microbiome;new technology;novel;Nucleotides;Organism;pathogen;Play;programs;Research;Resolution;response;Role;single molecule real time sequencing;software development;symposium;Techniques;technology development;Virulence

PROJECT_TITLE: High Resolution Characterization of Bacterial Epigenomes and Microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Hypofunction of parvalbumin (PV)-positive inhibitory interneuron circuits and imbalanced excitation-inhibition (E-I) ratio in feedforward sensory pathways likely contribute to abnormal sensory processing, including tactile hypersensitivity, in Autism Spectrum Disorders (ASDs), but the source of PV circuit hypofunction, the molecular mechanisms involved, and the generalizability beyond feedforward circuits remains unclear. I will address these knowledge gaps by asking: (1) Does PV hypofunction arise from defective homeostatic plasticity within PV circuits, possibly related to a broad impairment of cellular homeostasis in ASD? (2) What transcriptional and translational mechanisms mediate PV circuit homeostasis, are these abnormal in ASDs, and can they be rescued by novel CRISPR-based strategies? (3) Do top-down feedback sensory projections exhibit abnormal PV inhibition? Answering these questions will provide fundamental new knowledge about the mechanisms and commonalities of PV circuit deficits in multiple genetic models of ASD, and may lead to new therapeutic approaches to normalize cortical circuit function across ASDs.

PI_NAMEs: MONDAY, HANNAH  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;autism spectrum disorder;Behavioral;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Defect;deprivation;Electrophysiology (science);ETV1 gene;Exhibits;Failure;Feedback;Functional disorder;Gene Expression;genetic approach;Genetic Models;Genetic Transcription;genome editing;Homeostasis;Human;Hypersensitivity;Impairment;In Vitro;in vivo;individuals with autism spectrum disorder;insight;Interneurons;Knowledge;Measurement;Measures;Mediating;Messenger RNA;Methods;model of autism spectrum disorder;Modeling;Molecular;Molecular Target;mouse model;Mus;Neurons;novel;novel therapeutic intervention;optogenetics;Parvalbumins;Pathway interactions;Phenotype;Physiological;Physiology;posttranscriptional;Potassium;Protein Biosynthesis;Proteins;Pyramidal Cells;Reporting;Sensory;sensory cortex;sensory feedback;sensory input;sensory stimulus;Signal Pathway;Site;Somatosensory Cortex;Source;Synapses;Tactile;Testing;Therapeutic;Therapeutic Intervention;Touch sensation;transcription factor;Translating;Vibrissae;voltage;Wild Type Mouse

PROJECT_TITLE: Physiological and molecular mechanisms of impaired PV circuit homeostasis in Autism mouse models

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Chagas disease is a major vector borne parasitic disease caused by the protozoan parasite Trypanosoma cruzi, and our long-term goal is to develop a human therapeutic vaccine, to improve the control of Chagas disease. We propose to evaluate the safety and efficacy of a therapeutic vaccine formulation against T. cruzi infection in naturally infected rhesus macaques, alone and in combination with a low dose benznidazole, in a non-inferiority trial design compared with conventional benznidazole treatment. This work will be a major step towards clinical trials, and ultimately will lead to improved patient care and control of this important disease.

PI_NAMEs: DUMONTEIL, ERIC  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;Adjuvant;Adverse effects;Adverse event;Aftercare;Americas;Antigens;Appearance;Benznidazole;Biological Markers;Blood;canine model;Canis familiaris;Cardiac;Cardiovascular system;Cessation of life;Chagas Disease;chagasic cardiomyopathy;Chronic;Chronic Phase;Clinical;clinical development;Clinical Trials;Comparison arm;coronary fibrosis;cost effective;design;disability-adjusted life years;Disease;Disease Progression;disorder control;Dose;Economics;efficacy outcomes;Electrocardiogram;Enrollment;Evaluation;Event;follow-up;Future;Gene Expression Profile;Goals;Heart Diseases;heart function;Human;Immune;immunogenic;improved;In Vitro;Infection;innovation;Interruption;Life;Longterm Follow-up;LY6E gene;Macaca;Macaca mulatta;Measures;Monitor;mortality;mouse model;Mus;Myocardial dysfunction;Nifurtimox;nonhuman primate;Parasites;Parasitic Diseases;Patient Care;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;placebo group;Placebos;preclinical study;preservation;Prevention;Preventive vaccine;Privatization;Proteins;Randomized;Recombinants;Reporting;response;Risk;Safety;secondary outcome;Testing;Therapeutic;therapeutic evaluation;therapeutic vaccine;Tissues;treatment comparison;Treatment Efficacy;treatment group;Treatment Protocols;treatment response;trial comparing;trial design;Trypanosoma cruzi;Ultrasonography;Vaccination;vaccine candidate;vaccine formulation;Vaccine Therapy;Vaccines;vector-borne;Work;years of life lost

PROJECT_TITLE: Non-inferiority trial of a therapeutic vaccine against Chagas disease in naturally-infected rhesus macaques

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Genetics;Nutrition;Sleep Research

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-ST. LOUIS

PHR: PROJECT NARRATIVE This proposed research investigates the interconnection between the circadian clock and lipid metabolism, and the results will advance fundamental knowledge underlying the molecular and signaling mechanisms that regulate clock function, lipid production, and stress responses. This work will provide novel insights into the molecular process leading to metabolic and physiological dysfunctions associated with clock misalignments and disruptions. This outcome is relevant to the part of NIH’s mission that pertains to fostering fundamental discoveries and innovative research strategies as a basis for ultimately improving human health.

PI_NAMEs: WANG, XUEMIN  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Affect;Amino Acids;Arabidopsis;Binding;biological adaptation to stress;Biological Assay;Biosensor;Cell model;Cell Nucleus;Cell Proliferation;Cells;chromatin immunoprecipitation;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Darkness;Data;data mining;day length;Disease;Environment;Enzymes;Eukaryota;experimental study;Feedback;Fostering;Functional disorder;Future;Gene Expression;Genes;Genetic Transcription;genome editing;Glycerolipid Metabolism Pathway;Goals;Health;Homeostasis;Human;Hypocotyl;improved;in vivo;innovation;insight;Knowledge;Lead;Light;Link;Lipid Binding;lipid mediator;lipid metabolism;lipidomics;Lipids;Liposomes;Location;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mission;model organism;Modeling;Molecular;Monitor;Mouse-ear Cress;Mutagenesis;mutant;Mutation;novel;Outcome;Output;Pathologic Processes;Pathway interactions;Phosphatidic Acid;Physiological;Physiology;Plants;Process;Production;Regulation;Regulator Genes;Research;response;Role;screening;Signal Transduction;Specificity;Surface Plasmon Resonance;Testing;transcription factor;United States National Institutes of Health;Work

PROJECT_TITLE: Unraveling the molecular connections that link circadian rhythms and lipid metabolism

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: The Research Innovation in NeuroScience Education for Underserved Populations (RISE UP) program will support our efforts to equip outstanding undergraduate students from diverse and/or under-privileged backgrounds with research, professional, and social-emotional skills to thrive in cutting-edge neuroscience graduate programs. RISE UP scholars will be engaged in a rigorous summer program in neuroscience that will not only allow them to strengthen their research and professional development skills but will also address socio-emotional and cultural issues that may be unique to them. This innovative approach allows us to intervene early on in the educational pipeline and arm our undergraduate scholars with the necessary tools to adjust to the diverse rigors of graduate school.

PI_NAMEs: REYES, TERESA M (contact);SOLOMON, MATIA B

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Advisory Committees;Affinity;arm;career;Career Choice;Climate;Cognition;college;Communication;Communities;Country;cultural competence;design;Development;Dimensions;Disadvantaged;disadvantaged student;Doctor's Degree;Education;educational atmosphere;Educational workshop;Emotional;Ensure;Epilepsy;Ethics;ethnic minority;Ethnic Origin;Event;experience;Face;faculty mentor;Fellowship;Female;Financial Support;Funding;Geography;Goals;graduate school;Human Resources;implicit bias;improved;innovation;Institution;interest;Investments;Laboratories;Lead;Learning;Logistics;Maintenance;Medicine;Mentors;Methods;minority student;National Institute of Neurological Disorders and Stroke;Neurodevelopmental Disorder;Neuroimmune;neuroprotection;Neurosciences;Neurosciences Research;notch protein;Pain;Population;Population Heterogeneity;Population Programs;Process;programs;Race;racial minority;Readiness;recruit;Research;Research Personnel;responsible research conduct;skill acquisition;skills;social;Social isolation;socioeconomics;Stress;stress management;Stroke;student retention;Students;success;summer program;summer research;Talents;Time Management;tool;Training;Traumatic Brain Injury;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative HIV-exposed infants are at higher risk of adverse birth outcomes such as stillbirth, preterm delivery, small size for gestational age, and neonatal death than HIV-unexposed infants, and untreated co-infection with chlamydia or gonorrhea during pregnancy contributes substantially to these adverse birth outcomes in sub-Saharan Africa, including in Botswana. The proposed research will first use computer simulation modeling to estimate the clinical and economic impacts of chlamydia and gonorrhea infection among pregnant women with HIV in Botswana. We will next evaluate the cost-effectiveness of antenatal chlamydia and gonorrhea screening to improve maternal health; reduce mother-to-child transmission of HIV, chlamydia, and gonorrhea; and prevent adverse birth outcomes in Botswana.

PI_NAMEs: DUGDALE, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adverse birth outcomes;Affect;Africa South of the Sahara;Aftercare;Alternative Therapies;antenatal;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Award;Awareness;Birth;Botswana;budget impact;Calibration;care systems;career;Child;Child Health;Chlamydia;Clinical;clinical care;co-infection;Collaborations;Communicable Diseases;Computer Simulation;Conjunctivitis;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost effectiveness research;cost-effectiveness evaluation;Data;Derivation procedure;economic evaluation;economic impact;Economics;Event;evidence base;experience;Foundations;Gestational Age;global health;Goals;Gonorrhea;Health Policy;high risk;HIV;improved;Income;Infant;Infection;Link;Literature;Low Birth Weight Infant;Maternal and Child Health;Maternal Health;Mentors;Mentorship;Methodology;Methods;Modeling;models and simulation;Molecular;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Mothers;multidisciplinary;multiple data sources;Neonatal;neonatal care;Neonatal Intensive Care;Neonatal Mortality;novel;Nucleic Acid Amplification Tests;obstetric care;Odds Ratio;Outcome;Perinatal;Perinatal Infection;Physicians;Pneumonia;point of care;Positioning Attribute;Postpartum Period;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prevent;Publishing;Recommendation;reproductive health intervention;Research;Research Personnel;Resource-limited setting;Risk;Risk Reduction;routine care;screening;screening program;Sensitivity and Specificity;Sepsis;Sexually Transmitted Diseases;Small for Gestational Age Infant;standard of care;stillbirth;Symptoms;Syphilis;Techniques;Testing;tool;Toxic effect;Training;Woman;Women's Health;women's outcomes;Women's prevalence;Work

PROJECT_TITLE: Modeling the Effects of HIV, Chlamydia, and Gonorrhea in Mother-Infant Pairs in Botswana.

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PHR: Project Narrative Autosomal Dominant Polycystic Kidney Disease (ADPKD) affects over 12 million people worldwide, typically resulting in kidney failure in the fourth to seventh decade of life. Disease severity is affected by the degree of functional loss of the Polycystin-1 protein encoded by the primary disease gene PKD1. Building on a successful approach in other fields and data supporting dramatic benefit from proof-of-concept studies increasing PKD1 expression, this proposal will evaluate the extent to which blockade of PKD1 upstream open reading frame (uORF) translation can quantitatively increase functional PKD1 expression in vitro and characterize the clinical importance of this intervention on reducing cyst burden in mouse models.

PI_NAMEs: BESSE, WHITNEY ELISE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 5' Untranslated Regions;abdominal distension;Affect;Alleles;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autosomal Dominant Polycystic Kidney;Bacterial Artificial Chromosomes;base editing;Cell Line;Cell surface;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cyst;Cystic kidney;Data;design;Disease;dosage;effective therapy;Endoplasmic Reticulum;Epithelium;Epitopes;FDA approved;functional loss;Funding;Genes;Genetic Transcription;genome editing;genome-wide;Genomics;Growth;Hepatic Cyst;Human;Human Cell Line;Impairment;In Vitro;in vivo;in vivo Model;Initiator Codon;Institution;interest;Intervention;Kidney;Kidney Failure;Life;Liquid substance;Liver;Location;Luciferases;Messenger RNA;Modeling;mouse model;Mus;mutant;Mutation;novel strategies;Open Reading Frames;Pain;Pathogenicity;patient subsets;Patients;Peptides;Persons;Phenotype;PKD1 gene;PKD2 gene;PKD2 protein;polycystic kidney disease 1 protein;pre-clinical therapy;preclinical evaluation;preclinical study;PRKCSH protein;Production;protein expression;Proteins;Publishing;Renal tubule structure;Renilla Luciferases;Reporter;Ribosomes;RNA;RNA Sequences;Severities;Severity of illness;Site;Structure;Testing;Therapeutic;Therapeutic Intervention;Transfection;Translating;Translation Initiation;translational potential;Translations;Western Blotting;Work

PROJECT_TITLE: Therapeutic rescue of Polycystin-1 protein expression by targeting PKD1 upstream open reading frames

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Women's Health Research

PHR: Project Narrative  Childhood internalizing problems predict future social, health, and academic impairment; the tremendous burden of internalizing problems is disproportionately borne by girls. The proposed study will use multimodal time series data to evaluate how parents respond emotionally and physiologically to their daughters’ expressions of dysphoria and anger, during discussions of experiences of sadness and/or worry. Moment-to-moment parent emotion socialization (ES) processes may be altered by girls’ internalizing problems, constituting maladaptive cycles that reinforce the unusually strong and persistent experience of dysphoria associated with internalizing problems; these ES processes can then be investigated as a prospective risk processes for the onset of internalizing disorders.

PI_NAMEs: SOMERS, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TITLE: Dynamic multimodal parent emotion socialization processes as risk processes for school-aged girls’ internalizing problems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE While emotional well-being (EWB) promotes positive health across the lifespan, little is known about how to best increase EWB in ways that lead to downstream improvements in health. The goal of this network is to develop research resources and foster a cohesive community of interdisciplinary scholars focused on discovering which aspects of EWB are most tightly linked to physical health, which interventions most effectively increase EWB, and the biobehavioral processes that explain how EWB impacts health. The network leadership team unites three major research institutions (UCSF, Harvard, UC Berkeley), bringing together the infrastructure and scientific expertise in measurement, intervention development, and dissemination, needed to advance the science of well-being and health.

PI_NAMEs: EPEL, ELISSA S. (contact);MENDES, WENDY BERRY

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Affect;Aging;Area;Autonomic nervous system;Basic Science;Behavior;Big Data;biobehavior;Biosensor;burden of chronic illness;burden of illness;Cell Physiology;Chronic Disease;Cohort Studies;Collaborations;Communities;Consensus;Country;Data;data resource;Development;digital;digital health;digital platform;Early Intervention;Educational workshop;Elements;Epidemiology;Evidence based practice;experience;Family Study;FarGo;Fostering;Funding;Goals;Happiness;Harm Reduction;Health;Health and Retirement Study;Health behavior;Health Professional;Health Sciences;healthspan;healthy aging;heart rate variability;hedonic;improved;Infrastructure;innovation;insight;Institution;interdisciplinary collaboration;Intervention;Intervention Studies;Leadership;Libraries;Life;life span;Link;Loneliness;Longevity;Measurement;Measures;Mediator;Medicine;Mental Health;Mentorship;Methodology;Modeling;novel;optimism;pandemic disease;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Physiological;Physiology;Pilot Projects;Play;population health;Prevention;Process;psychosocial;Recovery;repository;Research;research and development;Research Institute;Research Personnel;Resources;restoration;Role;satisfaction;Science;Scientist;Senior Scientist;Shapes;Sleep;social;sociodemographic group;Stress;summer research;symposium;Technology;Testing;Theoretical model;therapy development;Time;tool;Training;United States National Institutes of Health;Well in self

PROJECT_TITLE: Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being


NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE The enteric nervous system regulates intestinal motility and regulates local homeostatic functions. Defects in enteric nervous system development lead to debilitating conditions such as Hirschsprung disease, in which neurons are gone from regions of the gut, and those who suffer from this anomaly suffer from intestinal obstruction and/or severe constipation. This research proposal will enhance our knowledge of the fundamental genetic and cellular mechanisms that regulate early development of the neural progenitor cells that give rise to the enteric nervous system.

PI_NAMEs: URIBE, ROSA A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Affect;Agreement;Anterior;Biological Assay;Biological Models;Candidate Disease Gene;Cell Cycle;cell fate specification;Cells;Chagas Disease;Chromosome Mapping;Collecting Cell;Colon;Colonic Aganglionosis;Complex;Computer Models;confocal imaging;Congenital Megacolon;Constipation;Coupled;Data;Data Set;Defect;Destinations;Development;Distal;effective therapy;Embryo;Embryonic Development;Ensure;Enteral;Enteric Nervous System;enteric neuropathy;Environment;Equilibrium;Esophageal achalasia;Event;experimental study;Eye;Foundations;Future;Ganglia;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;genetic signature;Genetic Transcription;Genomics;Goals;gut colonization;Hindgut;Homeostasis;Hormone secretion;Human;Immigration;In Situ;in utero;in vivo;in vivo imaging;Infiltration;innovation;intestinal barrier;Intestinal Motility;Intestinal Obstruction;Knowledge;Lead;Length;loss of function;Mammals;Maps;migration;Mitosis;Mitotic;Modeling;Molecular;Muscle;nerve stem cell;Nervous System control;nervous system development;Nervous System Disorder;neural;neurodevelopment;neurogenesis;Neuroglia;neuron development;Neuronal Differentiation;neuronal patterning;Neurons;novel therapeutics;Optics;optogenetics;Pathway interactions;Pattern;Peristalsis;Play;Population;Positioning Attribute;Process;programs;Proliferating;Research;Research Proposals;Resolution;Role;Series;Signal Pathway;Signal Transduction;spatiotemporal;Speed;Stem Cell Development;stem cell differentiation;stem cell migration;stem cell population;stem cell proliferation;stem cells;System;Testing;Therapeutic Studies;Time;Tissue Engineering;Tissues;transcription factor;transcriptomics;translational therapeutics;Tretinoin;Tube;Water;Zebrafish

PROJECT_TITLE: Genetic and extrinsic mechanisms governing early enteric nervous system development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE High food motivation among children is trait-like and increases risks of unhealthy dietary intake and obesity. Scientific knowledge of how parenting can best support healthy eating habits and growth among children who are predisposed to overeating is surprisingly limited. This investigation will provide the first comprehensive evidence of supportive food parenting approaches for obesity prevention that address the needs of highly food motivated children.

PI_NAMEs: FISHER, JENNIFER ORLET (contact);HUGHES, SHERYL O

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Authoritarianism;Basic Behavioral Science;Basic Science;Behavioral Research;Black race;Body mass index;Caregivers;Child;Child Rearing;Consumption;design;Diet Habits;dietary;dietary excess;Dietary intake;Dimensions;Disparity;Eating;Eating Behavior;eating in absence of hunger;Ecological momentary assessment;elementary school;Equity;ethnic minority;evidence base;experience;Family;feeding;Food;Foundations;goal oriented behavior;Goals;Growth;Healthy Eating;Heritability;Hispanic;Hyperphagia;Individual Differences;Intake;Intervention;Investigation;Knowledge;Literature;Low income;Measures;Methods;motivated behavior;Motivation;Nursery Schools;Obesity;obesity prevention;obesity risk;Outcome;parental influence;Parents;Population;prevent;Prevention;Prevention Research;programs;Proliferating;prospective;Prospective cohort;racial minority;Recommendation;recruit;Reporting;Research;Risk;Role;saturated fat;Specificity;Structure;success;sugar;theories;Time;trait;Unhealthy Diet;Weight;Work

PROJECT_TITLE: Deconstructing food parenting approaches to obesity prevention for the highly food motivated child

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative There is an unmet need to understand the cellular processes co-opted during human coronavirus replication, with an emphasis on identifying mechanisms underlying severe disease and potential therapeutic targets. Our preliminary data demonstrate that the host protein IRE1α plays a critical role in SARS-CoV-2 replication and cytokine responses. This proposal aims to understand how IRE1α contributes to severe COVID-19, and determine whether IRE1α represents a prognostic marker and therapeutic target.

PI_NAMEs: FINK, SUSAN LEILANI (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Affect;Aging;Anti-Inflammatory Agents;Biogenesis;biological adaptation to stress;Cell Culture Techniques;Cell Physiology;cell type;chemical genetics;Clinical;comorbidity;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 risk;current pandemic;cytokine;Data;Diabetes Mellitus;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Etiology;Evaluation;experience;experimental study;Floods;Future;gene induction;Genetic;genetic approach;Human;human coronavirus;human disease;Hypertension;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;inhibitor;insight;Integration Host Factors;Investigation;Life Cycle Stages;Mediating;Medical;Membrane Fusion;Messenger RNA;Modeling;Molecular;Molecular Virology;mouse model;novel;nuclease;Obesity;pandemic virus;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Play;pre-clinical;Prediction of Response to Therapy;Process;Production;Prognostic Marker;Protein Biosynthesis;Proteins;response;Risk Factors;RNA;RNA replication;RNA Splicing;Role;SARS-CoV-2 infection;severe COVID-19;Severity of illness;Specificity;Specimen;Testing;Therapeutic Effect;therapeutic target;tool;transcription factor;Viral;Virion;virology;Virus Diseases;Virus Replication;Work;XBP1 gene

PROJECT_TITLE: Role of IRE1 Alpha in Coronavirus Infections

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dietary Supplements;Genetics;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Multifactorially inherited neural tube defects (NTDs) are common structural birth defect whose prevalence has been reduced, but not eliminated by folic acid supplementation. Recent work suggests that folic acid non- responsive NTDs may be the result of abnormal mitochondrial folate transport. Our proposed research program will provide the molecular, cellular and genetic relationships of multiple gene networks related to the etiology of folate responsive and resistant NTDs.

PI_NAMEs: FINNELL, RICHARD H.;LEI, YUNPING  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: beta catenin;Biochemical;Biological Assay;Carbon;Cell Line;Cell Physiology;Cells;Characteristics;cohort;Complex;Conceptions;Congenital Abnormality;CRISPR/Cas technology;Cyst;Cytoplasm;design;Developing Countries;Development;Embryo;Environmental Risk Factor;Etiology;Failure;Folic Acid;Folic acid fortification;folic acid supplementation;Formates;Frequencies;gene network;Genes;Genetic;Genetic Screening;genetic variant;Genotype;Glycine;Health Policy;Heterozygote;Human;In Vitro;in vivo;in vivo evaluation;Incidence;Inherited;insight;Intervention;Investigation;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Luciferases;malformation;Mammals;Measures;Mediating;metabolic profile;Metabolism;Mitochondria;Molecular;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Neural Tube Closure;Neural Tube Defects;neurodevelopment;Neuroepithelial;novel;Pathway interactions;Play;Population;Prevalence;prevent;Process;programs;Proteins;Publishing;receptor;Regulation;Reporter;Reporting;Research;Research Project Grants;Resistance;Respiration;response;Risk;Risk Reduction;Role;Serine;Serum;Signal Pathway;Signal Transduction;SLC19A1 gene;Structural Congenital Anomalies;Testing;Tetrahydrofolates;Transgenic Mice;uptake;Variant;Wild Type Mouse;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of Slc25a32 and Its Interaction with Lrp6 in the Etiology of Neural Tube Defects

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Despite strong gene regulatory mechanisms there are often large cell-to-cell differences in gene expression between genetically identical cells. We aim to study the molecular mechanisms that generate these cell-to-cell differences in gene expression. These mechanisms help diversify cell types during normal development, contribute to chemotherapeutic resistance of cancer cells, and can be harnessed to improve practical applications that require uniform outcomes among cells.

PI_NAMEs: COHEN, BARAK A (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Affinity;cancer cell;cell type;Cells;Chromatin;chromosomal location;Development;Disease;DNA Binding Domain;Ectopic Expression;Environment;Enzymes;Epigenetic Process;experimental study;Frequencies;Gene Expression;Genes;Genetic Transcription;Goals;improved;Location;Measures;Messenger RNA;Metabolic;Modeling;Molecular;Natural Selections;Outcome;Pattern;Positioning Attribute;practical application;Production;Property;Regulation;Reporter Genes;Source;therapy resistant;Time;transcription factor

PROJECT_TITLE: Molecular Properties of Transcription Factors that Control Cell-to-Cell Variability in Gene Expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Traumatic Head and Spine Injury

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Improving the care of AD and related dementias is a national challenge, which demands integrated multidisciplinary approaches. This CARE system may help to improve patients’ independence and, thus, quality of life. It also helps to address the challenge of increasing demand for care and shortage of care resources for AD and related dementias.

PI_NAMEs: ZHAO, XIAOPENG  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: 18 year old;Accounting;Address;Age;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Auditory;Biomedical Engineering;brain computer interface;Caregivers;Caring;Cognitive;cognitive rehabilitation;cognitive testing;Collaborations;Communication;computer science;deep learning;Dementia;dementia care;Diagnosis;Discipline of Nursing;Emotions;Epilepsy;Exclusion Criteria;Family;feeding;Gerontology;Hour;human old age (65+);humanoid robot;improved;inclusion criteria;innovation;instrumental activity of daily living;Intelligence;interdisciplinary approach;Learning;Medical;medical specialties;mental state;motor impairment;multimodality;neurophysiology;older adult;Patient Self-Report;Patients;Performance;Personal Satisfaction;Persons;Post-Traumatic Stress Disorders;pregnant;Preparation;Provider;Psychological reinforcement;Quality of life;Recording of previous events;recruit;Reporting;Resources;Robot;robot assistance;Robotics;Schizophrenia;self supervised learning;Societies;Stress;Substance abuse problem;System;Traumatic Brain Injury;United States;unsupervised learning;usability;Visual

PROJECT_TITLE: SCH: Robotic Caregiver to Comprehend, Assist, Relieve, and Evaluate for Patients with Alzheimer’s Disease (Robotic CARE for AD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Project Narrative The VA provides care for approximately 26% of individuals with SCI in the U.S. Treatment costs are 6.5 times higher than the cost of treatment of an average Veteran, and effective therapies for this disorder are lacking. This project aims to evaluate the efficacy of 3D printed biomimetic scaffold, loaded with human neural progenitor cells and implanted sub-acutely, in a long-term clinically relevant, non-human primate model of cervical spinal cord contusion.

PI_NAMEs: KOFFLER, YACOV  (contact);TUSZYNSKI, MARK H.

PROJECT_TERMS: 3-Dimensional;3D Print;Admission activity;Anatomy;Animals;Architecture;Award;Axon;axon growth;axon regeneration;biocompatible scaffold;biomaterial compatibility;Biomimetics;Caring;Cervical;Cervical spinal cord structure;Clinical;Clinical Trials;clinically relevant;Contusions;Corticospinal Tracts;Data;Development;Disease;effective therapy;efficacy evaluation;efficacy study;efficacy testing;Electrophysiology (science);Esthesia;Exercise;Feasibility Studies;Forelimb;functional improvement;functional outcomes;Future;Hand functions;hand rehabilitation;Hindlimb;Home;Hospital Records;Hospitalization;Human;Implant;improved;Individual;Injury;injury and repair;innovation;Lesion;Macaca mulatta;Magnetic Resonance Imaging;manufacture;Mission;Modeling;Monkeys;Motor;Natural regeneration;nerve stem cell;Nervous System Trauma;neural;Neurophysiology - biologic function;Neurosciences;nonhuman primate;Outcome;Patient Care;Perfusion;Primates;Printing;Recovery;Recovery of Function;Reporting;Robotics;Rodent;safety study;scaffold;scale up;Science;severe injury;Shapes;Site;Spinal Cord;Spinal Cord Contusions;Spinal cord damage;Spinal cord injury;Spinal cord injury patients;Spinal Cord transection injury;stem cell biology;stem cell survival;stem cell technology;stem cell therapy;stem cells;synaptogenesis;System;Technology;Time;Tissues;Treatment Cost;Vascularization;Veterans;Vision;Work

PROJECT_TITLE: SCI Consortium Study: 3D Printed Scaffolds for Primate Spinal Cord Injury Repair

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative Pyrazinamide is a cornerstone drug used in the treatment of tuberculosis due to its ability to shorten treatment times and reduce relapse rates. Unlike all other antitubercular drugs, pyrazinamide is only active against tubercle bacilli under specific environmental conditions in vitro and in vivo. The focus of this project is to understand the basis for conditional antitubercular action of pyrazinamide in order to develop new approaches for improving its therapeutic activity.

PI_NAMEs: BAUGHN, ANTHONY D (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: amidase;Animal Model;antimicrobial;Automobile Driving;Bacillus;biological adaptation to stress;cell envelope;Cells;Cellular Immunity;Chemosensitization;Clinical;Coenzyme A;Combined Modality Therapy;Development;Disease;drug action;drug discovery;Drug usage;Elements;Environment;Exposure to;Genes;Genetic Epistasis;Genetic Variation;Goals;HIV/AIDS;Human;Immune;Immunity;Impairment;improved;In Vitro;in vivo;Infection;Integration Host Factors;Interferon Type II;Investigation;Knowledge;Laboratory culture;loss of function mutation;Macrophage;Mediating;Metabolism;Microbe;Molecular;Molecular Biology;Mus;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;novel;novel strategies;Nude Mice;Nutrient;Other Genetics;Oxidative Stress;Oxygen;Phenotype;Population;Predisposition;Prodrugs;Pyrazinamide;Pyrazinamide resistance;pyrazinoic acid;Reactive Nitrogen Species;Reactive Oxygen Species;Recombinants;Regimen;Relapse;Resistance;resistance mutation;response;Rest;Role;Signal Transduction;small molecule;stressor;T cell response;T-Lymphocyte;Therapeutic;treatment duration;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Wild Type Mouse

PROJECT_TITLE: The impact of pyrazinamide on metabolism in Mycobacterium tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(02)M]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

PHR: Pain is a complex sensation realized by most individuals at some point in his or her lives and the opioid receptor pathway has been identified to be involved in the regulation of pain management. The goal of this research project is characterize the opioid G-protein coupled receptor (GPCR) N-terminal domains that are postulated to modify the opioid receptor functional response. The impact of the anticipated results on the medicinal chemistry and pain research fields could advance the existing paradigms for ligand design strategies for opioid receptor based therapeutics, GPCR based therapeutics, as well as provide novel tools to probe pain management.

PI_NAMEs: HASKELL-LUEVANO, CARRIE  (contact);PORTOGHESE, PHILIP S

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Address;Adverse effects;Affinity;Agonist;Amino Acids;Analgesics;antagonist;Aspirin;Basic Science;beta-arrestin;Binding;Biology;Bypass;Chemicals;Clinical;Communities;Complex;Constipation;Data;design;Development;Disease;DNA sequencing;Drug abuse;Drug Design;drug discovery;endogenous opioids;Esthesia;European;evidence base;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Heroin;Human;In Vitro;in vivo;in vivo evaluation;Individual;Knowledge;Ligands;Molecular;Molecular Probes;Molecular Target;Morphine;mu opioid receptors;N-terminal;Nausea;novel;novel therapeutics;Opioid;Opioid Peptide;Opioid Receptor;Outcome;Pain;Pain management;pain perception;Pain Research;painful neuropathy;Pathway interactions;peptide A;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Population;Predisposition;protein aminoacid sequence;Proteins;receptor;Receptor Activation;receptor function;recruit;Regulation;Research;Research Project Grants;response;Role;Sedation procedure;side effect;Signal Transduction;Single Nucleotide Polymorphism;standard of care;Structure;Tertiary Protein Structure;Test Result;Therapeutic;Therapeutic Agents;therapeutic development;tool;Ventilatory Depression

PROJECT_TITLE: Chemical biology of Peptide Regulation of Opioid Receptor Function

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Homelessness;Lung;Lung Cancer;Prevention;Recovery Support Services;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Tobacco use and homelessness are inter-connected public health risk factors that contribute to and exacerbate health disparities. The proposed research, which is a community-based trial of a voluntary smoke- free home intervention to formerly homeless adults in permanent supportive housing seeks to mitigate these disparities by increasing voluntary adoption of smoke-free homes and increasing access to smoking cessation services. The study will assess the intervention’s efficacy and cost-effectiveness, and evaluate its potential for scalability and sustainability.

PI_NAMEs: VIJAYARAGHAVAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Adopted;Adoption;Adult;Age;alcohol abstinence;Alcohol consumption;Area;arm;authority;Behavior;brief intervention;Cancer Etiology;cancer health disparity;Cardiovascular Diseases;Characteristics;Chronic;Chronic Disease;Cities;Cluster randomized trial;Communities;Conflict (Psychology);cost effective;cost effectiveness;cost-effectiveness evaluation;Counseling;Death Rate;disability;Disparity;disparity reduction;environmental tobacco smoke exposure;Equity;evidence base;experience;Financial Hardship;Food;food insecurity;General Population;Goals;Harm Reduction;Health;health disparity;Home;Homeless persons;Homelessness;Housing;Income;Individual;Intervention;Intervention Trial;Left;Link;Low income;Malignant Neoplasms;marginalization;Medical;Mental Health;mortality;multi-component intervention;Pathway interactions;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;Poverty;Property;Provider;Public Health;Public Housing;Randomized;Recording of previous events;Reporting;Research;Resources;Risk;Risk Factors;San Francisco;Services;Site;Smoke;Smoke-free home;smoke-free policy;Smoker;Smoking;smoking cessation;smoking restriction;social;social health determinants;Social Work;substance use;Substance Use Disorder;supported housing;Testing;Time;Tobacco;tobacco control;tobacco products;Tobacco use;Training;Treatment Efficacy;U.S. Department of Housing and Urban Development;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: A community-based trial of a voluntary smoke-free home intervention in permanent supportive housing for formerly homeless adults


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The goal of this work is to transform dysphonic voice quality assessment in clinical practice and in research by establishing new psychometric scales that accommodate sustained phonation and connected speech. The multidimensional scales will be designed and evaluated with the goals of high validity, reliability, sensitivity, specificity, and most importantly, the responsiveness to change. These methods also will support development of precise, reliable and automated computational models of voice quality perception.

PI_NAMEs: EDDINS, DAVID A. (contact);GILLESPIE, AMANDA I;SHRIVASTAV, RAHUL

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Aftercare;Assessment tool;Attention;Auditory;auditory processing;Clinical;Clinical assessments;clinical care;clinical outcome measures;clinical practice;Clinical Research;Collaborations;Complex;Computer Models;Computer software;Data;design;Development;Diagnosis;Dimensions;Disease;Dysphonia;Elements;Engineering;Evaluation;Goals;Hearing;Human;improved;Individual;innovation;Intuition;Investigation;Judgment;Knowledge;Laboratories;Laboratory Study;Link;mathematical model;Mathematics;Measurement;Measures;Methods;Modeling;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Nature;novel;Outcome;Outcome Measure;Output;Pathology;Patients;Perception;Phonation;Procedures;Property;Psychoacoustics;Psychometrics;Psychophysics;Research;research clinical testing;Research Methodology;Science;Scientific Advances and Accomplishments;Series;Severities;Signal Transduction;Specificity;Speech;standard of care;success;Techniques;Testing;theories;Time;tool;Translating;Translations;Treatment outcome;United States National Institutes of Health;Variant;Voice;Voice Disorders;Voice Quality;Weight;Work

PROJECT_TITLE: A Comprehensive Psychoacoustic Approach to Voice Quality Perception

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases

PHR: Project Narrative: This study will determine whether we can develop HIV-specific allogeneic chimeric antigen receptor (CAR) T cells capable of evading recipient allorejection and controlling HIV replication in the absence of ART towards a functional cure for HIV.

PI_NAMEs: BOUTWELL, CHRISTIAN L. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acceleration;Allogenic;allotransplant;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;Autologous;B-Cell Acute Lymphoblastic Leukemia;base editing;Berlin;Binding;cancer immunotherapy;CAR T cell therapy;Cardiovascular Diseases;CCR5 gene;CD19 gene;CD28 gene;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Cellular immunotherapy;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Clinical;Clinical Trials;Consumption;cost;Cytomegalovirus;Data;Development;Disease;Disease Progression;Disease remission;DNA;efficacy study;engineered T cells;Exhibits;Functional disorder;Generations;Genes;Genetic;Head;Hematopoietic Neoplasms;Heterogeneity;HIV;HIV Infections;HIV vaccine;Human;human disease;humanized mouse;Immune;Immune response;Immune system;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Individual;Infection;Inflammation;Infusion procedures;interest;Interruption;Junk DNA;Knowledge;London;Macaca mulatta;Malignant Neoplasms;manufacturing cost;Mediating;Modification;Morbidity - disease rate;mortality;mouse model;novel;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;Phenotype;prevent;Production;prophylactic;Resistance;response;SIV;Source;stem cells;success;T cell response;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;transcriptomics;tumor;Vaccination;Variant;vector induced;vector-based vaccine;Viral;Viral Load result;viral rebound;Viral reservoir;Virus

PROJECT_TITLE: Development of Allogeneic CAR T Cell Therapy for a Functional Cure of HIV Infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Incarcerated pregnant women experience numerous sociodemographic and behavioral risks, which can compromise their health and the health of their infants. The proposed project is likely to have high public health impact by identifying key facilitators and barriers to implementing pregnancy and postpartum support programs in prisons, and documenting the outcomes among incarcerated women who receive these services. The project is relevant to the NICHD’s mission to ensure that every person is born healthy and that women suffer no harmful effects from reproductive processes.

PI_NAMEs: SHLAFER, REBECCA J. (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Admission activity;Age;Behavioral;Birth;Birth Weight;Breast Feeding;Caregivers;Cesarean section;Child;Childbirth;Communities;Companions;Complex;contextual factors;cost effectiveness;Data;Effectiveness;efficacy evaluation;Evaluation;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Geography;Gestational Age;Goals;Health;health equity promotion;Health Professional;Health Services;Hospital Records;implementation barriers;implementation context;Imprisonment;improved;Infant;Intervention;Interview;Justice;Lactation;Length;Low income;Maternal Health;maternal outcome;Measurement;Methods;Minnesota;Mission;Modeling;National Institute of Child Health and Human Development;neonatal health;Neonatal Intensive Care Units;neonatal outcome;obstetrical complication;Outcome;Participant;Patient Self-Report;Persons;Pilot Projects;Population;postpartum care;Postpartum Depression;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Rate;pregnant;Pregnant Women;Premature Birth;Prenatal care;Prisons;Process;process evaluation;Program Description;programs;Public Health;Reduce health disparities;Reporting;reproductive;Reproductive Health;Reproductive Process;Research;Research Personnel;Risk;Sampling;satisfaction;Services;Site;Skin;Societies;sociodemographics;Structure;System;United States;Woman;Women's Group;Women's Health;Work

PROJECT_TITLE: Pregnancy and Postpartum Support Programs for Women in Prison: Maternal and Neonatal Outcomes

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the results will have immediate positive impact for children with neonatal seizures due to early brain injury, their families, and the providers who care for them. Through this study, we will take innovative steps to understand the multifaceted genetic contributors to epilepsy after neonatal seizures. The proposed research is directly relevant to the NIH mission, which calls for the development of methods to enhance health and reduce illness and disability, to seek fundamental knowledge about the brain and nervous system, and to use that knowledge to help all children to achieve their full potential through reduction of the burden of neurological disease.

PI_NAMEs: GLASS, HANNAH CRANLEY (contact);SHERR, ELLIOTT

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Accounting;acquired epilepsy;Acute;Address;Adult;Age;Ambulatory Care Facilities;Benchmarking;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Caring;Child;classification algorithm;Clinical;clinical care;Clinical Data;clinical risk;clinically relevant;Code;cohort;Collaborations;Copy Number Polymorphism;Coronary Arteriosclerosis;Counseling;Data;design;Diagnosis;disability;DNA;Electroencephalography;Enrollment;Epilepsy;Epileptogenesis;excitotoxicity;exome sequencing;Family;follow-up;Foundations;Funding;Genes;Genetic;Genetic Predisposition to Disease;genetic registry;Genetic Risk;genetic risk factor;genetic testing;Glass;Goals;Health;Hemorrhage;high risk;high risk population;Homeostasis;improved;Incidence;Inflammation;Inflammatory;Infrastructure;Inherited;innovation;intervention program;Intervention Studies;Intervention Trial;Investigation;Knowledge;Life;Link;Magnetic Resonance Imaging;Measures;method development;Microarray Analysis;Mission;Modeling;National Institute of Neurological Disorders and Stroke;Neonatal;neonatal seizure;neonate;Nervous System;Nervous System Disorder;Neurology;Neuronal Plasticity;Neurosciences Research;neurotransmitter transport;novel;novel strategies;Observational Study;offspring;Parents;Pathogenicity;Pathway interactions;patient population;Phenotype;Play;Post-Traumatic Epilepsy;predictive modeling;prevent;preventable epilepsy;Process;Provider;Public Health;recruit;Registries;Research;Research Design;Research Personnel;Research Priority;Risk;Risk Factors;risk prediction;Risk Reduction;Role;Sampling;Seizures;Single Nucleotide Polymorphism;Site;Stroke;Study models;Targeted Research;Technology;Test Result;Testing;therapy design;Training;Traumatic Brain Injury;United States National Institutes of Health;Untranslated RNA;Variant

PROJECT_TITLE: NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy)

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: PROJECT NARRATIVE This project with apply novel generalizable methods in algorithmic fairness to examine unfairness among African-Americans in a commonly used predictive algorithm at the Veterans Health Administration and develop approaches to mitigate it. This project will yield an algorithmically fair algorithm that will incorporate data related to social determinants of health into the predictive algorithm. The study will also examine the impact of mitigating algorithmic unfairness on expected African-American enrollment in VA clinical programs targeting high-risk Veterans.

PI_NAMEs: NAVATHE, AMOL S (contact)

PROJECT_TERMS: Adopted;adverse outcome;Affect;African American;African American population;Algorithms;analytical tool;Care given by nurses;Caring;Cessation of life;Characteristics;Clinical;clinical application;clinical care;Data;data warehouse;Enrollment;Equity;experience;Exposure to;Face;Funding;Future;Goals;Health;health care disparity;health care service;health information technology;high risk;Home;hospice environment;Hospitalization;housing instability;improved;Individual;inequitable distribution;innovation;Investigation;Investments;Laboratories;Methods;Mission;Modeling;mortality;Needs Assessment;novel;Outcome;Palliative Care;patient subsets;Patients;prediction algorithm;Predictive Analytics;predictive modeling;Primary Care;primary care clinician;programs;Psychosocial Stress;Race;racial bias;racial disparity;Reduce health disparities;Reporting;Research;Resource Allocation;Resources;Risk;risk prediction;risk prediction model;screening;Services;social health determinants;Structural Racism;Subgroup;Surveys;telehealth;Testing;transportation access;Veterans;Veterans Health Administration

PROJECT_TITLE: Racial Bias in a VA Algorithm for High-Risk Veterans

STUDY_SECTION_NAME: Social Determinants of Health[HS2A]


NIH_SPENDING_CATS: Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The incidence of metabolic diseases such as obesity and diabetes has risen to epidemic proportions. Poor muscle growth resulting from intrauterine growth restriction (IUGR) contributes to lifelong reductions in muscle mass (sarcopenia), obesity, and diabetes risk. This project will determine the molecular mechanisms responsible for reduced fetal skeletal muscle growth, so that nutritional strategies can be targeted to improve muscle growth in IUGR fetuses and neonates.

PI_NAMEs: BROWN, LAURA DAVIDSON (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Adult;Affect;Alanine;amino acid metabolism;Amino Acids;Animals;Body Composition;Body Weight;Brain;Branched-Chain Amino Acids;branched-chain-amino-acid transaminase;Catabolism;Cells;Citric Acid Cycle;comparison control;Data;Defect;design;Development;Diabetes Mellitus;diabetes risk;Dietary Intervention;disorder risk;Epidemic;Exposure to;falls;Fatty acid glycerol esters;fetal;Fetal Growth;Fetal Growth Retardation;Fetal Reduction;Fetal Sheep;Fetal Skeleton;Fetus;Gluconeogenesis;Glutamine;Goals;Growth;Growth Factor;Harvest;Hindlimb;Human;Hypertrophy;improved;Incidence;Incubated;Infusion procedures;innovation;Insulin;Insulin Resistance;Intramuscular;Isoleucine;Knowledge;Label;Leucine;life span;Metabolic Diseases;Metabolism;metabolomics;Molecular;Molecular Target;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle Proteins;Na(+)-K(+)-Exchanging ATPase;neonate;novel strategies;Nutrient;Nutritional;Obesity;obesity risk;Organ;perinatal period;Placental Insufficiency;Pregnancy;prevent;Production;programs;Protein Biosynthesis;protein expression;Proteins;Proteomics;Qualifying;reduced muscle mass;Regulation;Research;response;restoration;Risk;Role;Sarcolemma;sarcopenia;sarcopenic obesity;Serum;sheep model;Signal Transduction;skeletal muscle growth;solute;Starvation;targeted treatment;Techniques;Testing;Time;uptake;Valine;Weight

PROJECT_TITLE: Regulation of Fetal Skeletal Muscle Growth in IUGR


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Liver Disease;Vector-Borne Diseases

PHR: Project Narrative Zoonotic viruses such as Rift Valley fever virus (RVFV) can cause rare but deadly outbreaks among domesticated animals and human populations. Our proposed work will define critical host factors for virus entry and identify novel targets that will facilitate therapeutic development. Recent outbreaks and the emerging nature of the mosquito vectors for RVFV, coupled with a rising potential of misuse in the form of bioterrorism, underscore the importance of the proposed studies to global health.

PI_NAMEs: AMARASINGHE, GAYA K. (contact);HARTMAN, AMY L

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;Animal Model;Animals;Anti-viral Agents;Antibodies;antiviral drug development;Bar Codes;Binding;Biochemical;Biochemistry;Biological;Bioterrorism;Bunyaviridae;Category A pathogen;Cattle;CD209 gene;Cell Line;Cell Survival;cell type;Cells;Complement;conditional knockout;Country;Coupled;CRISPR screen;CRISPR/Cas technology;Culicidae;Data;design;Disease;Disease Outbreaks;Domestic Animals;Dose;Elements;Emerging Communicable Diseases;Encephalitis;Endogenous Factors;epidemic preparedness;Family;Gene Deletion;Genes;genome-wide;Genomics;Genus Phlebovirus;global health;glucose-regulated proteins;Glycoproteins;Guide RNA;Hamsters;Health;Heparitin Sulfate;hepatic necrosis;Hepatocyte;Human;Immunology;In Vitro;in vivo;Infection;innovation;Insecta;Integration Host Factors;interdisciplinary approach;International;Knock-out;Knockout Mice;Knowledge;LDL-Receptor Related Protein 1;Libraries;Ligands;Lipoprotein Receptor;Liver;Liver diseases;Livestock;loss of function;Low Density Lipoprotein Receptor;Macrophage;Methods;Molecular;Monkeys;mosquito-borne;mouse model;Mus;mutant;National Institute of Allergy and Infectious Disease;Nature;Neurons;new therapeutic target;North America;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Population;prevent;Productivity;programs;prophylactic;Proteins;Proteomics;Reagent;receptor;Receptor Cell;Research Personnel;Resource-limited setting;Resources;Retinal Vasculitis;Rift Valley fever virus;RNA Viruses;Role;Saudi Arabia;Sheep;socioeconomics;structural biology;Survivors;System;Textiles;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;tool;transmission process;Travel;Tropism;United States;Vaccines;Validation;vector mosquito;Viral;Viral Hemorrhagic Fevers;Viral Pathogenesis;virology;Virulent;Virus;Virus Diseases;Work;Zoonoses

PROJECT_TITLE: Identification and Characterization of Entry Factors Critical for Rift Valley Fever Virus Infection and Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Infectious Diseases;Sepsis

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Sepsis and ischemic myocardial infarction (MI) are two critical illnesses with very high mortality. The goal of this research program is to address a unique function of extracellular microRNA in innate immune activation, tissue inflammation, organ injury, and cardiac dysfunction in sepsis and cardiac ischemia. The research supported by this grant will improve our understanding of the mechanism and treatment of these diseases as well as miRNA biology.

PI_NAMEs: CHAO, WEI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Address;Animals;Attenuated;Biology;biotypes;Blood;Blood Coagulation Disorders;Cardiomyopathies;Clinical Data;Computational algorithm;Critical Illness;cytokine release syndrome;Disease;Etiology;extracellular;Genetic;Goals;Grant;Heart Injuries;Human;immune activation;improved;Infarction;Inflammation;Innate Immune Response;Ischemia;Mediating;MicroRNAs;Molecular;mortality;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;Natural Immunity;organ injury;Pathogenesis;Pathway interactions;Pattern;Plasma;programs;Reperfusion Therapy;Reporting;Research;Research Support;RNA;Role;Sepsis;septic;septic patients;Severities;Tissues;TLR7 gene;transcriptome sequencing;Uridine;Work

PROJECT_TITLE: Extracellular miRNAs, innate immunity, and critical illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Thousands of rare Variants of Uncertain Significance (VUS) exist in transmembrane proteins associated with Mendelian disease, representing a major challenge for genomic medicine. I will deploy integrative phenotyping methods in a large biobank and test the in vitro function of transmembrane variants at multiple levels of scale, from low to high-throughput. This work will establish a pipeline for reclassifying transmembrane VUS's to (likely) benign or pathogenic and result in the identification of many new disease-associated variants.

PI_NAMEs: GLAZER, ANDREW M. (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: American;Arrhythmia;Benign;biobank;Biological Assay;Biology;BMPR2 gene;Body System;California;Cardiac;career;career development;Cell surface;Cellular Assay;Classification;ClinVar;cohort;Collaborations;Collection;Coupled;Coupling;Data;Data Set;Databases;deafness;Deposition;Disease;disease phenotype;disease-causing mutation;DNA;Doctor of Philosophy;Electronic Health Record;experience;Failure;Fellowship;Flow Cytometry;follow-up;General Population;Genes;Genetic;genetic testing;Genomic medicine;Genomics;Genotype;Goals;Hemochromatosis;HFE gene;high throughput screening;Human;improved;In Vitro;in vitro Assay;in vitro testing;Individual;innovation;Integral Membrane Protein;Ion Channel;Lead;Libraries;Link;loss of function;Measures;Medical Genetics;medical schools;Membrane;Membrane Proteins;Mendelian disorder;Mentors;Methods;mutant;next generation sequencing;Organ;patch clamp;Pathogenicity;Patient Care;Patients;Phase;Phenotype;Postdoctoral Fellow;Property;protein protein interaction;Proteins;Proteome;Publishing;Pulmonary Hypertension;rare variant;receptor;Reporting;Research;Resources;Risk;RNA Splicing;Scoring Method;Signaling Protein;Surface;Survey Methodology;Symptoms;Testing;trafficking;Training;training opportunity;Universities;Validation;Variant;variant of unknown significance;Work

PROJECT_TITLE: A pipeline for identifying disease-causing variants in transmembrane proteins

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS