NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Rare Diseases

PI_NAMEs: MORGAN, ERIC  (contact)

PROJECT_TERMS: African American;Amyloidosis;Anatomy;Automobile Driving;Biological Markers;Blood;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiotoxicity;Cardiovascular system;Caring;Characteristics;Cicatrix;Clinical;clinical implementation;Clinical Research;Collaborations;Competence;Complex;Coronary;coronary fibrosis;Data;Development;Diabetes Mellitus;Diagnostic;Disease;District of Columbia;Drug usage;EFRAC;Etiology;Exercise;Female;follow-up;Functional disorder;Future;Gadolinium;Geographic Locations;Goals;Health;healthy volunteer;Heart;Heart Diseases;Heart failure;Hospitals;Hypertension;Hypertrophic Cardiomyopathy;Image;Infarction;Inflammation;Injury;insight;International;Ionizing radiation;Knowledge;Laboratories;Left Ventricular Function;Long-Term Effects;Lung;Magnetic Resonance;Magnetic Resonance Imaging;male;Malignant neoplasm of esophagus;Manuscripts;Measurement;Measures;Mechanics;meetings;metabolomics;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardial perfusion;Myocardial tissue;Myocarditis;National Heart, Lung, and Blood Institute;novel;Oncology;Organ;participant enrollment;patient population;Patients;Perfusion;Phenotype;Physiology;Positioning Attribute;preservation;pressure;Probability;Process;programs;Property;Proteomics;Protocols documentation;Publications;Radiation therapy;Research;Research Subjects;response;Rest;Sample Size;Stress;Stretching;System;Technical Expertise;Techniques;Testing;Tissues;treatment strategy;Washington;Work

PROJECT_TITLE: Technical development of cardiovascular Magnetic Resonance Imaging


ACTIVITY: ZIA

ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology

PI_NAMEs: KANTHI, YOGENDRA  (contact)

PROJECT_TERMS: Autoimmune;autoinflammatory;autoinflammatory diseases;bench to bedside;Blood Vessels;Cardiovascular system;Cause of Death;Clinical;clinical phenotype;Clinical Research;clinically relevant;Coagulation Process;Disease;early-career faculty;Fibrinolytic Agents;Functional disorder;Goals;Hematology;Human;Immune checkpoint inhibitor;In Vitro;Inflammasome;Inflammation;Inflammatory;Inherited;interest;Interleukin-1 beta;Investigation;Laboratories;Malignant Neoplasms;Mendelian disorder;Mentors;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;novel therapeutic intervention;Pathway interactions;patient population;Patients;Postdoctoral Fellow;pre-clinical;Process;Public Health;Risk;Role;Science;Signal Transduction;Stroke;Therapeutic;thromboinflammation;Thrombosis;thrombotic;tool;translational study;United States;Vascular Diseases;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: Human Translational Studies of Vascular Thrombosis and Inflammation


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PROJECT_TERMS: Acute;Animal Model;Anti-phospholipid Syndrome;Antiphospholipid Antibodies;Autoantibodies;Autoimmune;Binding Proteins;Biological Assay;Biological Markers;Blood;Blood Coagulation Disorders;Blood Vessels;Cells;Cessation of life;Clinic;Clinical;Clinical Trials;Coagulation Process;combat;convalescent plasma;coronavirus disease;coronavirus pandemic;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 test;Critical Illness;current pandemic;Cytoplasm;cytotoxic;defense response;Development;Disease;DNA;early-career faculty;Endothelium;Europe;extracellular;extracellular vesicles;Fibrin;fluidity;Foundations;future pandemic;Genetic Transcription;Height;high risk;Hospitalization;Hospitals;Host Defense;Human;human coronavirus;Immune;Immune response;Immunoglobulin G;improved;In Vitro;Individual;Inflammation;Inflammatory;Interruption;Investigation;Leukocyte L1 Antigen Complex;Lymphocyte;Measurement;Measures;Mentors;Mission;monocyte;Morbidity - disease rate;mortality;Myelogenous;National Heart, Lung, and Blood Institute;neutrophil;novel;novel therapeutics;Organ;Organ failure;Outcome;pandemic disease;participant enrollment;Pathologic;Patients;Perfusion;Phenotype;Phospholipids;Physiological;prospective;Public Health;Publishing;Reporting;Resolution;Resources;Respiratory Failure;response;Role;S100A8 gene;Sampling;SARS-CoV-2 infection;Sepsis;Serum;severe COVID-19;Signal Transduction;single-cell RNA sequencing;Study models;Surface;Testing;Therapeutic;therapeutic target;thromboinflammation;Thrombophilia;Thrombosis;thrombotic;Time;Tissues;Translating;translational study;United States National Institutes of Health;Variant;vascular bed;Vascular Diseases;Venous Thrombosis;Viremia;Virus Diseases;Work

PROJECT_TITLE: Unraveling Cytotoxic and Thrombotic Signals in COVID-19


NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

PI_NAMEs: MIZUNO, NAOKO  (contact)

PROJECT_TERMS: Actins;Affect;Axon;axon injury;axon regeneration;Axotomy;Behavior;Binding;Biochemical;Biological;biophysical techniques;Biophysics;Brain;Cell membrane;cell motility;Cell Physiology;Cell Shape;Cells;Central Nervous System;Communication;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Cytosol;Decision Making;Deterioration;Development;Distal;Elements;Endoplasmic Reticulum;Environment;Event;F-Actin;Filopodia;Focal Adhesions;Fostering;In Situ;In Vitro;Individual;insight;Integrins;interest;Length;Light Microscope;light microscopy;macromolecular assembly;Maintenance;Mediating;Membrane;Membrane Proteins;Methods;Microfilaments;Microtubules;migration;Mitochondria;Molecular;Molecular Analysis;Morphogenesis;Mus;Natural regeneration;Neoplasm Metastasis;Nerve Degeneration;Nervous System;neural network;Neurofibrillary Tangles;neuron regeneration;Neurons;Organelles;Pathologic;Pathway interactions;Pharmaceutical Preparations;Play;polarized cell;premature;Preparation;Process;Protein Biosynthesis;Proteins;receptor;reconstitution;Regulation;repaired;Resolution;response;Ribosomes;Role;secretory protein;Series;Shapes;Signal Pathway;Signal Transduction;Site;stem;Structure;Surface;Surveys;System;Talin;Testing;Thinness;Time;tumor growth;Validation;Vinculin;Visual

PROJECT_TITLE: Molecular organization of pathways governing cell-shape formation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

PI_NAMEs: THEIN, SWEE LAY  (contact)

PROJECT_TERMS: Acute;Acute Pain;Adenosine Triphosphate;Adverse effects;Affinity;Binding;Biological Availability;Blood;Blood Vessels;Cardiopulmonary;Clinical;Complication;Data;Deoxygenated Sickle Hemoglobin;diphosphoglycerate;Disease;Dose;Drug Kinetics;Drug Targeting;enzyme substrate;Enzymes;Erythrocytes;Evaluation;Event;Fetal Hemoglobin;Frequencies;functional status;Glutamine;Glycolysis;health related quality of life;Hemoglobin;Hemoglobin concentration result;Hospitalization;Human;hydroxyurea;improved;Membrane;Monitor;Oral;Organ;Oxygen;Pain;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;phase 1 study;Phase II Clinical Trials;Phase II/III Clinical Trial;Phosphoenolpyruvate;polymerization;Polymers;pre-clinical;prescription opioid;Process;Production;Publishing;Pyruvate;Pyruvate Kinase;pyruvate kinase deficiency;Reporting;response;Role;Safety;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;small molecule;Source;Supportive care;Symptoms;Syndrome;System;Testing;Thalassemia;therapeutic target

PROJECT_TITLE: Evaluation of the safety, tolerability, pharmacokinetics, and pharmacodynamics of long-term mitapivat dosing in subjects with stable sickle cell disease


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Acute;Autoantibodies;Blood Vessels;Clinic;Clinical;Clinical Research;Clinical Trials;clinically relevant;Coagulation Process;Critical Illness;Diagnostic;Disease;early-career faculty;Endothelium;extracellular;FDA approved;Future;Goals;Human;immune modulating agents;Immunobiology;innate immune function;insight;Mentors;Molecular;neutrophil;Outcome;Pathologic;Phenotype;Production;randomized, clinical trials;Research Personnel;Sampling;Signal Transduction;System;therapeutic target;thromboinflammation;translational study;United States National Institutes of Health

PROJECT_TITLE: Vascular Immunobiology Mechanistic and Translational Studies


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Organ Transplantation;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Transplantation

PI_NAMEs: AGBOR-ENOH, SEAN  (contact)

PROJECT_TERMS: Acute;Admixture;Algorithms;allograft rejection;Allografting;Antibodies;antibody-mediated rejection;Area;biobank;Biological Markers;Biopsy;Blood;Blood Cells;Bronchoscopy;Caring;Cause of Death;cell free DNA;Cells;Cessation of life;Characteristics;Chronic;Circulation;Clinical;Clinical Data;Clinical Research;Cohort Studies;Collection;Complement;COVID-19;Diagnosis;diagnostic tool;DNA;DNA Sequence;Drug Targeting;effective therapy;efficacy testing;Environment;FDA approved;Functional disorder;Generations;Genetic;Genome;Genomics;Goals;Graft Rejection;Heart Transplantation;Histopathology;Hospitals;Immunologics;improved;Infection;inhibitor;Injury;Interobserver Variability;Laboratories;Life;Liquid substance;lung allograft;Lung Diseases;Lung Transplantation;Mediating;Mediator;metropolitan;Mission;Molecular;Monitor;multiple omics;National Heart, Lung, and Blood Institute;Natural History;novel;novel diagnostics;Organ;Organ Transplantation;Outcome;participant enrollment;Pathway interactions;Patient Monitoring;patient population;Patient Recruitments;Patient risk;patient stratification;Patients;Performance;Phagocytes;Placebos;Plasma;post-transplant;Prevention;Principal Investigator;Process;programs;Publishing;pulmonary arterial hypertension;racial disparity;remote monitoring;Research;Research Infrastructure;response;Risk Factors;safety testing;sample collection;Sampling;Series;Site;Solid;SYK gene;targeted treatment;Testing;transplant centers;Transplant Recipients;Transplantation;Treatment Failure;Tyrosine Kinase Inhibitor;Waiting Lists

PROJECT_TITLE: Cell-free DNA to detect transplant rejection


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

PI_NAMEs: KEMPER, CLAUDIA  (contact)

PROJECT_TERMS: Acute;Area;Brain;brain cell;Cells;Complement;complement system;Disease;Experimental Autoimmune Encephalomyelitis;experimental study;Future;gene complementation;Health;Immune;in vivo;Infection;LoxP-flanked allele;Meningeal;Meninges;mouse model;Mouse Strains;Multiple Sclerosis;Mus;Nerve;neuroinflammation;neuron development;Peptides;Reporter;Research;Role;Serum;Severity of illness;System

PROJECT_TITLE: The complosome in meningeal health and disease


PI_NAMEs: REMALEY, ALAN THOMAS (contact)

PROJECT_TERMS: Apolipoproteins B;Biological Assay;Biological Markers;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cells;Cholestasis;Cholesterol;Clinical;Consensus;Development;Diagnosis;Dyslipidemias;Eligibility Determination;Equation;Event;Future;Genetic;Guidelines;High Density Lipoproteins;International;Kidney Diseases;lecithin cholesterol acyltransferase deficiency;Lipids;Lipoproteins;Low-Density Lipoproteins;Measures;Methods;Monitor;novel;particle;Patients;Plasma;Publishing;Recommendation;Testing;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Development and assessment of cardiovascular risk biomarkers


NIH_SPENDING_CATS: Genetics;Sleep Research

PI_NAMEs: HARBISON, SUSAN  (contact)

PROJECT_TERMS: Alzheimer's Disease;Breeding;Candidate Disease Gene;Cardiovascular Diseases;circadian;circadian pacemaker;Circadian Rhythms;Complex;Darkness;Data;disorder risk;DNA;Drosophila genus;Drosophila melanogaster;epidemiology study;falls;Female;fly;Gene Expression;gene network;Genes;Genetic;Genetic Polymorphism;genome wide association study;Genomics;Goals;Heritability;Hour;Human;Inbreeding;Light;male;Maps;markov model;Modeling;Mutation;Phenotype;Process;Publishing;Research;response;RNA;Role;Sampling;Sleep;Sleep Deprivation;Sleep Fragmentations;Testing;Time;trait;transcriptomics;Variant;Work

PROJECT_TITLE: Identification of polymorphic variants impacting sleep in Drosophila


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ROGER, VERONIQUE  (contact)

PROJECT_TERMS: Age;American Heart Association;Area;black men;Black race;black women;Cardiovascular Diseases;cardiovascular risk factor;Censuses;Circulation;Code;cohort;Cohort Studies;Communities;Commuting;Data;demographics;design;Enrollment;Epidemiology;experience;follow-up;Goals;hazard;Health behavior;health inequalities;Heart failure;Incidence;Inequity;Low income;Low Income Population;Medicaid;Medicare;meetings;men;Modeling;mortality;Oral;Outcome;Participant;Persons;population based;Primary Prevention;Prospective, cohort study;Publishing;Race;Risk;Rural;rural area;Rural Health;Rural Population;rurality;Services;sex;Socioeconomic Status;Southeastern United States;Standardization;study population;Testing;United States Centers for Medicare and Medicaid Services;Urban Population;White Women;Woman

PROJECT_TITLE: Rurality and Heart Failure: The Southern Community Cohort Study


PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Age;Alanine;Algorithms;American;American Heart Association;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;biobank;Blood Pressure;Body mass index;Books;Branched-Chain Amino Acids;Cardiovascular Diseases;Cessation of life;Characteristics;Chronic Obstructive Pulmonary Disease;Citrates;Clinic;Clinical;Clinical Data;clinical risk;cohort;Cohort Studies;Communities;Community Health;Complex;Congestive Heart Failure;Creatinine;Data;design;Diabetes Mellitus;Diagnosis;EFRAC;Electronic Health Record;Enrollment;Epidemiology;epidemiology study;Equipment and supply inventories;Evaluation;frailty;Glucose;Guidelines;hazard;Heart;Heart failure;High Density Lipoproteins;high risk;indexing;Individual;Insulin Resistance;Investigation;Isoleucine;Ketone Bodies;Leucine;Life Style;Lipoproteins;Malnutrition;Manuscripts;Measurement;Measures;meetings;Meta-Analysis;Metabolic;metabolomics;Methods;Mission;mortality;mortality risk;New York;novel;Nuclear Magnetic Resonance;Obesity;particle;Patients;Persons;Phenotype;Plasma;Population;Population Study;Preventive;prognostic;prognostic value;prospective;Publishing;Recommendation;Research;Risk;Risk Estimate;risk prediction;risk stratification;Sampling;sex;Smoking;Smoking Status;Societies;Stratification;Survival Rate;Syndrome;systemic inflammatory response;Testing;Therapeutic;Triglycerides;unsupervised learning;Valine;Woman;Work

PROJECT_TITLE: Heart failure Metabolomics: NMR studies


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence

PROJECT_TERMS: American Heart Association;angiogenesis;aptamer;Attenuated;biobank;Bioinformatics;Biological Markers;Books;Cardiology;Cessation of life;Characteristics;Chronic Kidney Insufficiency;Clinic;Clinical;Clinical Data;cohort;Collaborations;Communities;comorbidity;Complex;Confidence Intervals;Congestive Heart Failure;Data;design;effective therapy;EFRAC;Electronic Health Record;Epidemiology;epidemiology study;Equipment and supply inventories;Etiology;European;Foundations;Framingham Heart Study;Heart failure;imaging program;Immune response;Individual;Inflammation;Infrastructure;International;Ischemia;Kidney Diseases;Machine Learning;Manuscripts;Measurement;meetings;Meta-Analysis;mortality;mortality risk;novel;Pathway Analysis;Pathway interactions;Patients;Phenotype;Plasma Proteins;Play;Population Heterogeneity;Population Study;predictive signature;Preparation;prognostic;prognostic value;Proteins;proteomic signature;Proteomics;Renal function;Risk;risk stratification;Role;Sampling Studies;Societies;Syndrome;Technology;Therapeutic;Validation;Work

PROJECT_TITLE: Heart failure proteomics: an epidemiology study


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Social Determinants of Health

PROJECT_TERMS: Address;Age;aged;Anxiety;beneficiary;Black race;Caring;Cause of Death;Characteristics;Circulation;Clinical;Code;Communities;Cross-Sectional Studies;Disparity;Environment;Epidemic;Epidemiology;Ethnic Origin;Event;experience;health care availability;health disparity;Health Services Accessibility;Healthcare;Healthcare Systems;Heart failure;High Prevalence;human old age (65+);Hypertension;ICD-10-CM;Individual;insight;International Classification of Diseases;low socioeconomic status;male;Measures;men;middle age;military health system;Military Personnel;military service;Modeling;Modification;Morbidity - disease rate;mortality;Odds Ratio;Persons;Population;Post-Traumatic Stress Disorders;pre-clinical;Prevalence;Prevention;Proxy;Publishing;Race;Research;Risk Factors;sex;sex disparity;Smoking;sociodemographics;trend;Veterans;Woman

PROJECT_TITLE: Epidemiology of Heart Failure in a Universal Healthcare system


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Orphan Drug;Pain Research;Patient Safety;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: active comparator;Adult;Adverse event;Anemia;Bilirubin;Binding;Clinical;clinical efficacy;Data;design;Double-Blind Method;Drug Kinetics;Echocardiography;efficacy evaluation;Ensure;Erythrocytes;Erythropoietin;Fatigue;Functional disorder;Genes;Globin;Goals;Heme;Hemoglobin;Hemolysis;Hemolytic Anemia;Human;Hydration status;improved;Investigation;Laboratories;Lactate Dehydrogenase;Membrane;Modeling;Monitor;Multicenter Studies;Mutation;open label;Oxidative Stress;Oxygen;Pain;Patients;Pharmacodynamics;Phase;Placebo Control;Placebos;Play;polymerization;Polymers;Process;Proteins;Pyruvate Kinase;Quality of life;Questionnaires;Randomized;Reporting;Reticulocyte count;Role;Safety;Serious Adverse Event;Sickle Cell;Sickle Cell Anemia;sickling;Sleep;Solubility;Testing;therapeutic candidate;United States National Institutes of Health;Walking

PROJECT_TITLE: A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Mitapivat in Subjects With Sickle Cell Disease


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Hematology;Pain Research;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Abnormal Hemoglobins;Acute;Adopted;Affect;African American;African ancestry;Amino Acids;beta Globin;Biological Markers;Birth;Blood flow;Blood Vessels;Cardiovascular system;Cerebrum;Chest;Chronic;chronic pain;Clinical;clinical application;clinical center;Data;Devices;Disease;Echocardiography;endothelial dysfunction;Enrollment;Erythrocytes;Ethnic Origin;Evaluation;Exercise;Glutamic Acid;hemodynamics;Hemoglobin;hemoglobin AA;Hemoglobinopathies;Hemolysis;Hemolytic Anemia;Hypoxia;Impairment;Individual;Inflammation;Inherited;Kidney;Lead;life span;Literature;Malignant Breast Neoplasm;Measurement;Minority Groups;Monitor;muscle physiology;Near-Infrared Spectroscopy;Optics;Organ;Outcome;Outpatients;Participant;Patients;Physiological;point of care;Polymers;Protocols documentation;Recurrence;Reperfusion Injury;Reporting;research study;response;Science;screening;Shapes;Sickle Cell;Sickle Cell Anemia;sickling;Site;Structure;Techniques;Technology Assessment;Testing;tissue oxygenation;Tissues;United States;Valine;Variant;Vascular Diseases;Vascular Endothelium;vaso-occlusive crisis;vaso-occlusive pain;Visit;Walking

PROJECT_TITLE: Exploring Near Infrared Spectroscopy (NIRS) technologies for assessment of muscle physiology, tissue oxygenation, and blood flow in patients with Sickle Cell Disease (SCD


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Acute;Address;Adverse event;Amino Acid Substitution;Animal Disease Models;Animal Model;Animals;Anions;Anticoagulation;Band Cell;beta Globin;Biochemical;Biological Markers;Blood Platelets;Cardiovascular system;Cell membrane;Cell Physiology;Cellular Metabolic Process;Clinical;Coagulation Process;Complex;COVID-19;Data;design;Development;Disease;Dose;Enrollment;Erythrocyte Anion Exchange Protein 1;Erythrocytes;Event;Exhibits;experience;Exposure to;extracellular;Face;FDA approved;Frequencies;Functional disorder;Genes;Glutamic Acid;Goals;Hemoglobin;hemoglobin polymer;Hemolysis;Hemorrhage;Histones;Hypoxia;Idiopathic Thrombocytopenic Purpura;Immune;immunothrombosis;In Vitro;Incidence;Individual;Inflammatory;Institutional Review Boards;Kidney;Laboratories;life span;Lung;Mediator;Molecular;Monitor;mortality;Neurologic;neutrophil;Neutrophil Activation;novel;Oral;Oxygen;particle;Patients;phase 1 study;Phase I Clinical Trials;Phosphorylation;Phosphotransferases;Phosphotyrosine;Platelet Activation;Play;Positioning Attribute;Process;Production;Reactive Oxygen Species;Recurrence;Reperfusion Injury;research study;Risk;Role;Safety;safety assessment;Sampling;Serine Protease;Serious Adverse Event;Severities;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;Signal Pathway;Signs and Symptoms;Specific qualifier value;Stroke;Study Subject;SYK gene;symptomatology;thrombogenesis;thromboinflammation;Thrombophilia;Thrombosis;Time;time interval;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;United States National Institutes of Health;Valine;Vascular Diseases;vascular injury;vaso-occlusive crisis;Venous;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with stable sickle cell disease


NIH_SPENDING_CATS: Aging;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Lung;Prevention;Social Determinants of Health

PI_NAMEs: WONG, JASON  (contact)

PROJECT_TERMS: Aging;Air;American Heart Association;Androgens;Asthma;Atherosclerosis;atmospheric conditions;biobank;Bioinformatics;Biological;Biological Aging;candidate marker;Cardiovascular Diseases;case control;Characteristics;Chemical Exposure;chromosome X loss;chromosome Y loss;Chronic Disease;climate change;Communities;Cross-Sectional Studies;Data;data integration;Diagnostic;DNA Methylation;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Epidemiology;epidemiology study;Estradiol;European;exome sequencing;experience;Funding;Future;Genetic;Genetic Predisposition to Disease;Genets;Genome;Genomic Instability;Genotype;Geographic Locations;Goals;Gonadal Steroid Hormones;Heart;heart disease risk;Heart Diseases;Heart failure;high dimensionality;Human;interest;International;Journals;Length;Leukocytes;Lung Diseases;Measurement;Measures;Mediating;men;Metabolic;Methods;Modernization;Molecular;mosaic loss;Mosaicism;multiple omics;Mutagenesis;Mutation;National Heart, Lung, and Blood Institute;Non-Malignant;novel;Paper;Pathogenesis;Persons;Population;programs;Prospective cohort;Prospective, cohort study;Public Health;Publishing;regional difference;Research;Respiratory Disease;Retroelements;Risk;risk prediction;risk stratification;Role;Source;Special Population;telomere;translational potential;United Kingdom;Visit;Woman

PROJECT_TITLE: Biological mechanisms underlying the relationships between environmental exposures and risk of respiratory and cardiovascular diseases


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Lung;Orphan Drug;Pediatric;Pulmonary Hypertension;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: ELINOFF, JASON  (contact)

PROJECT_TERMS: Abbreviations;Adenylate Cyclase;Affect;Animals;Apoptosis;arteriole;Atrial Heart Septal Defects;Attenuated;autosome;blood glucose regulation;BMPR2 gene;Cardiac;cardiac magnetic resonance imaging;Catalytic Domain;caveolin 1;CD44 gene;Cell model;cell motility;Cell Proliferation;Cells;Child;Chronic;Chronic small plaque psoriasis;clinical center;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Congenital Heart Defects;Control Animal;Core Facility;Cre lox recombination system;CXCL10 gene;Defect;Development;Dideoxy Chain Termination DNA Sequencing;Distal;Dose;Endoplasmic Reticulum;Endothelial Cells;endothelial dysfunction;Endothelin-1;Endothelium;Enzymes;Exhibits;experimental study;Expression Profiling;Fibroblasts;G6PC3 gene;Gene Expression;Genetic;genome-wide;Glucose;glucose metabolism;glucose-6-phosphatase;Glucose-6-Phosphate;Glycogen Storage Disease Type I;Goals;heart function;Homeostasis;Human;Hydrolysis;Hypoxia;immunocytochemistry;Immunofluorescence Immunologic;Impairment;In Vitro;in vivo;Incidence;induced pluripotent stem cell;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Interferon Activation;Interferons;Investigation;Knock-out;Knockout Mice;Lesion;loss of function mutation;Lung;Malignant Neoplasms;Mediating;Membrane Glycoproteins;Metabolic;mimetics;Modeling;Molecular;Monocrotaline;mortality;mouse model;mRNA Expression;Mus;Mutation;National Heart, Lung, and Blood Institute;Neutropenia;neutrophil;new therapeutic target;NOS3 gene;novel therapeutics;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;PI3K/AKT;PIK3CG gene;Placebos;pre-clinical;Process;Production;programs;protein expression;Protein Isoforms;Proto-Oncogene Proteins c-akt;Protocols documentation;prototype;Psoriasis;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;pulmonary vascular cells;pulmonary vascular remodeling;Rattus;Reproducibility;Resistance;response;RNA Splicing;Role;Serum;Severe congenital neutropenia;Signal Transduction;sildenafil;Site;skin lesion;small molecule inhibitor;Stains;STAT1 gene;Structure;Structure of parenchyma of lung;SU 5416;Syndrome;System;Systolic Pressure;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tool;Transcript;Transgenic Mice;Translating;United States National Institutes of Health;Variant;Vascular remodeling;Vasodilator Agents;Ventricular;Western Blotting

PROJECT_TITLE: Cellular Models of PAH-Associated Molecular Defects as a Tool for Identifying New Therapeutic Targets


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Apoptosis;arteriole;Autopsy;Blood Coagulation Disorders;Blood Vessels;Cardiovascular Manifestation;Cardiovascular system;cell type;Cells;Cessation of life;COVID-19 patient;COVID-19 pneumonia;digital;Disease;Distal;Dose;Electron Microscopy;Endothelial Cells;Endothelium;experimental study;Hour;Human;Hypoxemic Respiratory Failure;In Situ Hybridization;In Vitro;Infection;Inflammatory Infiltrate;Injury;Lung;lung microvascular endothelial cells;Microscopy;Molecular;mortality;Multisystem Inflammatory Syndrome in Children;Mutation;novel coronavirus;NRP1 gene;Nucleocapsid;Organ;pandemic disease;particle;permissiveness;Proteins;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;Recombinants;RNA;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Secondary to;Shock;Stroke;Syndrome;systemic inflammatory response;Thrombus;TMPRSS2 gene;Transcript;transcriptomics;Variant;Vascular Endothelium;vascular inflammation;venous thromboembolism;Viral;viral RNA;Virus;Virus Replication

PROJECT_TITLE: Cellular and Molecular Consequences of SARS-CoV2 Infection in Pulmonary Vascular Endothelium


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

PROJECT_TERMS: Alleles;antagonist;Anti-Inflammatory Agents;Arteries;Autoimmune Diseases;autoinflammatory diseases;Binding;Biological Assay;Biotin;Biotinylation;Candidate Disease Gene;Cells;Cessation of life;Chemicals;Clinical;Complex;cytotoxicity;Data;Digestion;Disease;Dose;drug development;Drug Industry;Endothelium;experimental study;FDA approved;follow-up;Gene Expression;Gene Library;Gene Targeting;Genes;Genetic Transcription;genome-wide;Heart failure;high throughput screening;Human;improved;In Vitro;Incubated;Inflammation;Inflammatory;innovation;Knock-in;Left;Libraries;liquid chromatography mass spectrometry;luminescence;Lung;Measures;Mineralocorticoid Receptor;miniaturize;Molecular;multicatalytic endopeptidase complex;National Center for Advancing Translational Sciences;novel;novel therapeutics;Patients;Peptides;Pharmaceutical Preparations;Proliferating;protein complex;Proteins;Proteome;prototype;pulmonary arterial hypertension;pulmonary artery endothelial cell;pulmonary vascular cells;Reproducibility;right ventricular failure;RNA Interference;RNA interference screen;Safety;Sampling;screening;side effect;Small Interfering RNA;small molecule libraries;Spironolactone;Streptavidin;System;Testing;Therapeutic;Titrations;transcription factor TFIIH;Transfection;Ubiquitin;vascular inflammation;Xeroderma Pigmentosum

PROJECT_TITLE: Proteasomal Degradation of XPB as a Novel Mechanism for Treating Inflammation


NIH_SPENDING_CATS: Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Acute;Acute Pain;Affinity;ANXA5 gene;arm;Biological Markers;Blinded;Blood flow;Blood Vessels;brain magnetic resonance imaging;Cell Survival;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrum;Chronic;Clinical;Companions;Complication;Data;Disease;Dose;Double-Blind Method;Enrollment;Erythrocytes;Event;Flow Cytometry;Fluorescent Probes;follow-up;Frequencies;Glutamine;glycation;Half-Life;Hemoglobin concentration result;Hemolytic Anemia;Hospitalization;hydroxyurea;Hypoxia;imaging modality;Individual;insight;Institution;Label;Laboratories;Mass Spectrum Analysis;Measurement;Measures;metabolic rate;metabolomics;Methodology;muscle physiology;Near-Infrared Spectroscopy;Observational Study;open label;Organ;Osmosis;Oxygen;Oxygen Consumption;Pain;Pathway interactions;Patients;Phase;phase 1 study;Phosphatidylserines;Placebo Control;Placebos;Population;potential biomarker;prescription opioid;primary endpoint;Proteomics;Protocols documentation;Randomized;Reactive Oxygen Species;response;Role;Safety;Sample Size;Sampling;secondary endpoint;Sickle Cell;Sickle Cell Anemia;sickling;Supportive care;System;Technology;Testing;Time;time interval;tissue oxygenation;TNFRSF5 gene;trend;Tyrosine Phosphorylation;United States National Institutes of Health

PROJECT_TITLE: Observational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell Disease


PROJECT_TERMS: Area;Calendar;Cessation of life;Clinical;Clinical Data;Communities;Complex;Computerized Medical Record;Data;District of Columbia;Event;Funding;Goals;Heart failure;insight;Institutional Review Boards;Link;Manuals;Maryland;Measures;Molecular;mortality;multiple omics;Participant;Phase;Phenotype;Plasma;Population Heterogeneity;Population Sciences;Population-Based Registry;Prospective, cohort study;Records;recruit;Reporting;Site;Syndrome;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Multi Scale Phenotyping of Heart Failure in Diverse Populations


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Hematology;Human Genome

PI_NAMEs: LEVY, DANIEL  (contact)

PROJECT_TERMS: Address;adverse outcome;Affect;Age;age acceleration;age related;Alleles;Boston;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Chronic lung disease;Clinical;Clonal Expansion;Coronary Arteriosclerosis;Cross-Sectional Studies;Data;Data Analyses;Data Set;Disease;DNA;DNA Sequencing Facility;fitness;Framingham Heart Study;Frequencies;Gene Mutation;Genome;genome sequencing;Grant;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;heteroplasmy;Impairment;Inflammatory;insight;Ischemic Stroke;Jackson Heart Study;Knowledge;Link;Longitudinal Studies;Methods;Mitochondria;Mitochondrial DNA;mitochondrial genome;Molecular Profiling;mortality;mouse model;mutant;Mutate;Mutation;Nature;Nuclear;Observational Study;Participant;Phenotype;Production;programs;Risk;Risk Factors;Sampling;Signal Transduction;Somatic Mutation;Time;timeline;Trans-Omics for Precision Medicine;transcriptome sequencing;Universities;Vermont;Whole Blood;whole genome

PROJECT_TITLE: The Dynamic Genome


NIH_SPENDING_CATS: Clinical Research

PROJECT_TERMS: Affect;Anatomy;Biological Markers;Blood;Blood flow;Blood Vessels;Clinic;Clinical Data;constriction;Development;Diagnosis;Diagnostic Procedure;diagnostic value;Disease;Early Diagnosis;Environment;Goals;Health;Image;imaging approach;Imaging technology;improved;insight;Magnetic Resonance Imaging;Microvascular Dysfunction;Monitor;Near-Infrared Spectroscopy;novel;organ growth;patient population;Patients;Performance;Research;Role;sensor;sensor technology;Techniques;Therapeutic;therapeutic target;Time;tissue oxygenation;Tissues;Vascular Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Multi-Functional Assessment of Vascular Networks


ACTIVITY: ZIC

ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: INDIG, FRED  (contact)

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Aging;Binding;Brain;cannabinoid receptor;Cell Cycle Progression;Cell Membrane Proteins;Cell Nucleus;Cell Physiology;Cells;Cellular biology;cellular imaging;claudin-1 protein;Collaborations;Color;confocal imaging;Confocal Microscopy;Consult;Consultations;Core Facility;Cytoplasm;Cytoplasmic Structures;density;Development;Diagnosis;DNA;DNA biosynthesis;DNA Damage;Emerging Technologies;Endocrinology;Endocytosis;Epidermal Growth Factor Receptor;Equipment;Experimental Designs;experimental study;Extramural Activities;Family;filamin;Freezing;Genes;Glucocorticoid Receptor;GPR55 receptor;Histologic;Histology;Human;Image;Image Analysis;image processing;imaging facilities;imaging study;Imaging Techniques;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Intramural Research;Investigation;Islets of Langerhans;isopentane;Journals;Kinetics;Lasers;late endosome;Ligands;light microscopy;Lighting;Liquid substance;Lysosomes;Malignant Neoplasms;Maryland;Masks;Measures;Melanoma;Melanoma Cell;member;Metastatic Melanoma;Methodology;Methods;MicroRNAs;Microscope;Microscopy;Mission;Mitochondria;Mitosis;Modeling;Modification;Molecular Biology;Muscle;Muscle Mitochondria;National Institute of Biomedical Imaging and Bioengineering;Nature;Nitrogen;novel;Nuclear;Nuclear Protein;operation;Optics;Organelles;Paper;Patients;Peer Review;Phosphoric Monoester Hydrolases;Phosphorylation;Postdoctoral Fellow;protein complex;protein distribution;protein transport;Proteins;Protocols documentation;PTPRC gene;Publications;Publishing;ratiometric;Receptor Activation;receptor binding;Receptor Protein-Tyrosine Kinases;reconstruction;Reporting;Research;Research Personnel;Resolution;Resources;RNA;RNA-Binding Proteins;Sampling;sarcopenia;Scanning;Scientist;Services;Signal Transduction;Sorting;Specimen;src-Family Kinases;stress granule;structural biology;Structure;submicron;sugar;superresolution microscopy;syndecan;System;T-Cell Activation;T-Lymphocyte;Techniques;Technology;technology validation;Testing;Tight Junctions;Time;Tissue Sample;tool;trafficking;Training;tumorigenesis;ubiquitin ligase;ultra high resolution;United States National Institutes of Health;Universities

PROJECT_TITLE: NIA Confocal Imaging Facility


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

PI_NAMEs: FITZGERALD, TRACY  (contact)

PROJECT_TERMS: Alleles;Auditory;Auditory Brainstem Responses;Auditory Threshold;Biophysics;Calibration;cell regeneration;Cellular biology;cochlear development;Collaborations;Core Facility;Data;Data Analyses;Data Collection;design;Development;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Equipment;Evoked Potentials;Exercise;Experimental Designs;Exposure to;External auditory canal;gene therapy;Head Movements;hearing impairment;hearing screening;Hearing Tests;interest;investigator training;Laboratories;laboratory experience;laboratory experiment;Labyrinth;lectures;Maintenance;Measures;member;microphone;Military Personnel;Missense Mutation;Molecular Genetics;mouse model;Mus;Mutant Strains Mice;National Institute on Deafness and Other Communication Disorders;Nervous System;Nervous System Trauma;Neurosciences;noise exposure;Organ;otoacoustic emission;otoconia;ototoxicity;Outer Hair Cells;Patients;Pharmaceutical Preparations;Physiological;Physiology;Postdoctoral Fellow;Preparation;prevent hearing loss;programs;Protocols documentation;Psychiatry;Publications;remediation;Research;Research Institute;Research Personnel;response;restoration;Saccule and Utricle;Scientist;segregation;Sensory;Sensory Physiology;Services;sound;Sum;Techniques;Testing;Training;Vestibular Aqueduct;Vestibular dysfunction;Vestibular function;Vestibular Function Tests;vestibular system

PROJECT_TITLE: Mouse Auditory Testing Core Facility


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: PISZCZEK, GRZEGORZ  (contact)

PROJECT_TERMS: Affinity;Biological;biophysical properties;Biophysics;Categories;Collaborations;Communities;Consultations;Core Facility;detector;Development;DNA;Field Flow Fractionation;fluidity;Fluorescence;Hour;instrument;Kinetics;Laboratories;Lasers;Ligands;light scattering;luminescence;macromolecule;Measurement;Methods;Microfluidics;Mission;Molecular Conformation;Molecular Weight;nanoparticle;National Heart, Lung, and Blood Institute;Postdoctoral Fellow;Principal Investigator;Proteins;Reader;Refractive Indices;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Scanning;Scientist;Services;Shapes;stoichiometry;Students;System;Temperature;Thermodynamics;Titrations;Training;Twin Multiple Birth;United States National Institutes of Health;Workload;zeta potential

PROJECT_TITLE: Biophysics Core Facility


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PI_NAMEs: SWENSON, ROLF  (contact)

PROJECT_TERMS: Antibodies;Automation;Binding;Cells;Chemicals;Chemistry;clinical development;clinical imaging;Communities;Databases;Dendrimers;Development;Doctor of Philosophy;drug discovery;Drug Kinetics;experience;Goals;Image;imaging agent;imaging capabilities;imaging modality;imaging probe;imaging study;improved;inhibitor;innovation;interest;Intramural Research;Intramural Research Program;Journals;Knowledge;Label;Laboratories;Ligands;Link;Magnetic Resonance Imaging;meetings;metabolomics;Methods;molecular imaging;nanoparticle;National Heart, Lung, and Blood Institute;next generation;novel;operation;optical imaging;Peer Review;Peptides;Pharmaceutical Chemistry;Positron-Emission Tomography;posters;Problem Solving;Production;programs;protein degradation;Publications;Publishing;Radiolabeled;Reporting;Research;Research Personnel;Resources;scale up;Scientist;single photon emission computed tomography;small molecule;tool;Translations;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Chemistry and Synthesis Center (formerly IPDC)


PI_NAMEs: DAGUR, PRADEEP  (contact)

PROJECT_TERMS: advanced analytics;Apoptosis;Biological Assay;Cell Cycle;Cell Separation;Cells;chemokine;Complex;Consultations;Continuing Education;Core Facility;cost;cytokine;Cytometry;Data;Data Analyses;Development;Ensure;Equipment and supply inventories;experience;Experimental Designs;experimental study;Flow Cytometry;Goals;high dimensionality;Hour;Image;Immunoassay;Immunology;Immunology procedure;Immunophenotyping;instrument;instrumentation;Intramural Research;Intranet;Laboratories;Lymphocyte Subset;Manuscripts;Measurement;Methods;Mission;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;new technology;novel;operation;Policies;Quality Control;Recovery;Research;Research Personnel;Resources;Safety;Schedule;Science;Services;Site;Technical Expertise;Training;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Flow Cytometry Core Facility


PI_NAMEs: SYED, ZULFEQHAR  (contact)

PROJECT_TERMS: 3-Dimensional;Antigens;Biological;Cell Culture Techniques;Cells;chemical fixation;Core Facility;Cryoultramicrotomy;digital imaging;Dryness;Electron Microscope;Electron Microscopy;Equipment;Freeze Substitution;Freezing;Imaging Device;immunocytochemistry;Immunoperoxidase Technics;improved;Ions;Knowledge;Label;Learning;Light Microscope;light microscopy;Lipids;Membrane;Methods;Molecular Structure;Morphology;nanoGold;National Heart, Lung, and Blood Institute;Negative Staining;Organ;Organism;Polymers;Preparation;preservation;pressure;Property;Proteins;Research;Resolution;Sampling;Scanning;Scanning Electron Microscopy;Scientist;Services;Silver;Specimen;Structure;Surface;Techniques;tissue culture;Tissues;tomography;Training;Transmission Electron Microscopy;Vesicle

PROJECT_TITLE: Electron Microscopy Core


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: LIU, CHENGYU  (contact)

PROJECT_TERMS: Animal Model;Biological Assay;Biology;Clustered Regularly Interspaced Short Palindromic Repeats;Embryo;experimental study;Fertilization in Vitro;gene editing technology;Generations;Genes;Genetic Engineering;Genome engineering;human disease;human model;Knock-in Mouse;Knock-out;mature animal;Methods;Microinjections;Micromanipulation;Mission;mouse genome;mouse model;Mus;National Heart, Lung, and Blood Institute;Research Project Grants;Scientist;Services;stem cell differentiation;Technology;technology development;Teratoma;Time;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Viral Vector

PROJECT_TITLE: NHLBI Transgenic Core


NIH_SPENDING_CATS: Biomedical Imaging;Machine Learning and Artificial Intelligence

PI_NAMEs: COMBS, CHRISTIAN  (contact)

PROJECT_TERMS: 3-Dimensional;Cells;Cellular biology;Collaborations;Comb animal structure;Custom;Data Analyses;Dedications;deep learning;Development;Disease;Equipment;experience;experimental study;flexibility;Goals;Human Resources;Image;image processing;imaging capabilities;imaging modality;improved;instrument;intravital microscopy;light microscopy;Machine Learning;Methodology;Microscope;Microscopy;Mission;National Heart, Lung, and Blood Institute;operation;Paper;Persons;programs;Publishing;reconstruction;Research;Research Personnel;response;Services;Side;superresolution microscopy;Techniques;Tissues;Training;two photon microscopy;two-photon;ultra high resolution;United States National Institutes of Health;Work

PROJECT_TITLE: Light Microscopy Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PI_NAMEs: ZOU, JIZHONG  (contact)

PROJECT_TERMS: Acceleration;Affect;Alleles;Allogenic;Autologous;Basic Science;Bibliography;Binding;Biological Assay;Budgets;Cardiac Myocytes;CD34 gene;Cell Culture Techniques;Cell Line;Cells;Chronic;Collaborations;Collection;Consultations;Core Facility;cost;CRISPR/Cas technology;Deposition;Detection;differentiation protocol;Discipline;disease model;Drug Screening;Engraftment;Exhibits;Extramural Activities;Failure;Fee-for-Service Plans;Fibroblasts;Flow Cytometry;G-Banding;gene correction;Gene Deletion;Gene Dosage;gene editing technology;gene function;Gene Transfer Techniques;Generations;Genes;Genetic Fingerprintings;genetic manipulation;Goals;Hematopoietic stem cells;Histologic;human disease;human induced pluripotent stem cells;human pluripotent stem cell;immune cell infiltrate;Immunosuppression;improved;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;interest;Iodides;Karyotype determination procedure;Knock-in;knockout gene;Laboratory Research;Loss of Heterozygosity;Luciferases;Macaca mulatta;Mediating;Methods;Mutation;Mycoplasma;Myocardial Infarction;Myocardium;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;novel therapeutic intervention;Paper;Peripheral Blood Mononuclear Cell;Plasmids;pluripotency;Pluripotent Stem Cells;Point Mutation;Positron-Emission Tomography;Procedures;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;Reagent;Recovery;regenerative;Regenerative Medicine;Reporter;Reporter Genes;Research;Research Personnel;Sampling;Scientist;Services;Skin;Sodium;stem cell genes;Stem Cell Research;stem cell self renewal;stem cell technology;stem cells;symporter;Teratoma;Testing;Time;Training;Transplantation;United States National Institutes of Health

PROJECT_TITLE: NHLBI iPSC Core Facility


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Heart Disease;Rare Diseases

PI_NAMEs: SACK, MICHAEL  (contact)

PROJECT_TERMS: Angiography;Area;Blinded;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiovascular system;Carotid Artery Plaques;Chronic;Clinical;Clinical Research;clinical training;contrast enhanced;Coronary;Coronary Arteriosclerosis;detector;Development;Disease;Doctor of Medicine;Echocardiography;efficacy evaluation;Evaluation;Familial Hypercholesterolemia;Functional disorder;gadobutrol;Genes;Genetic;Heart;Hyperlipoproteinemia;Image;Image Analysis;image reconstruction;imaging detection;insight;International;Investigation;Ischemia;lipid disorder;Lipids;Lipoproteins;Magnetic Resonance Imaging;Metabolism;Microvascular Dysfunction;Mitral Valve;Mitral Valve Insufficiency;Myocardial dysfunction;Natural History;neovascularization;new technology;next generation;novel;open label;Operative Surgical Procedures;Outcome;Pathogenesis;Patients;prospective;Protocols documentation;Radiation;Radiation Dose Unit;randomized trial;Rare Diseases;rare genetic disorder;reconstruction;Registries;repaired;Reporting;Research;Research Personnel;Sickle Cell Anemia;Study Section;suburb;System;Techniques;Technology;Ultrasonography;Vascular System;volunteer;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cardiovascular Clinical Section Studies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology;Natural Products;Orphan Drug;Rare Diseases;Sickle Cell Disease

PI_NAMEs: LEE, DUCK-YEON  (contact)

PROJECT_TERMS: Acetic Acids;Acetyl-CoA C-Acetyltransferase;Adenosine Diphosphate Ribose;Amino Acids;amyloid formation;Anti-viral Agents;Antibody-drug conjugates;Arachidonic Acids;Betaine;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Blood;Budgets;Cells;Chemicals;Chromatography;Complex;conditioning;Consultations;Contracts;Data Analyses;Detection;Development;Dose;Drosophila genus;Dyes;Enzymes;Epigenetic Process;equipment training;fertility preservation;Fluorescence;gene therapy;genome editing;Glucosylceramides;glucosylsphingosine;Growth;Hematopoietic stem cells;High Pressure Liquid Chromatography;Human;instrumentation;Interferon Type I;ion source;isoquercetin;Kinesin;Label;Laboratories;Ligands;liquid chromatography mass spectrometry;Liver;Macrophage;Maintenance;Mass Spectrum Analysis;Measurement;Metals;Methods;Microtubules;Mitochondria;Modeling;monocyte;mouse model;Mus;National Heart, Lung, and Blood Institute;Nucleotides;Oligonucleotides;operation;Outcome;Peptides;Phase;Photometry;Physiological;placebo controlled trial;Plasma;Polyamines;Post-Translational Protein Processing;Protein Chemistry;protein purification;Proteins;Proto-Oncogene Protein c-kit;Publications;Quercetin;Randomized;Recombinant Proteins;repaired;Research Personnel;Residual state;Rest;Rhesus;Saliva;Sampling;Services;Sickle Cell Anemia;Site;small molecule;Solvents;Sputum;sterol O-acyltransferase 1;Streptavidin;Structure;System;Time;Transplantation;Vitamin E;Xenograft procedure

PROJECT_TITLE: Biochemistry Core


PI_NAMEs: LI, YUE-SHENG  (contact)

PROJECT_TERMS: Basic Science;ChIP-seq;Clinical Research;cost effectiveness;deep sequencing;DNA sequencing;DNA Sequencing Facility;Ensure;exome sequencing;flexibility;Funding;Genomics;Goals;instrument;Libraries;nanopore;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;next generation sequencing;Preparation;Quality Control;Research Personnel;sequencing platform;Services;single cell sequencing;Technology;Time;Training;transcriptome sequencing;United States National Institutes of Health

PROJECT_TITLE: DNA Sequencing Core


ACTIVITY: ZID

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Health Services;Heart Disease

PI_NAMEs: LEDERMAN, ROBERT J (contact)

PROJECT_TERMS: Aorta;aortic valve replacement;Back;Blood Vessels;Cardiac;Cardiology;cardiology service;cardiovascular emergency;Cardiovascular system;Caring;Catheterization;Catheters;Clinical;clinical center;Collaborations;Diagnostic;District of Columbia;Educational process of instructing;Heart;Hospitals;Hour;image guided;innovation;Inpatients;Intervention;Intramural Research;Medical center;medically necessary care;Medicine;Motivation;National Heart, Lung, and Blood Institute;non-invasive imaging;Nurses;Outpatients;Patients;Physicians;Procedures;programs;Protocols documentation;Reporting;Research;Research Personnel;Services;skills;Techniques;Therapeutic;Translating;Travel;United States National Institutes of Health;University Hospitals;Washington

PROJECT_TITLE: Diagnostic and interventional cardiovascular catheterization


PI_NAMEs: LEVINE, STEWART  (contact)

PROJECT_TERMS: Area;Biopsy;Bronchial Provocation Tests;Bronchoscopy;Cardiopulmonary;Certification;Childhood;Clinical;clinical center;Clinical Medicine;Clinical Protocols;Clinical Research;Clinical Services;clinical training;Cold Therapy;Complement component C4;Consult;Consultations;Credentialing;Critical Care;Education;Educational Curriculum;Electromagnetics;Electronics;Environment;Exercise Test;Exhalation;Fellowship;Fellowship Program;Guidelines;Intervention;Intramural Research;Joints;Laboratories;Lasers;Link;Lung;Maryland;Measurement;Medical center;Medicine;microendoscopy;Military Personnel;Modality;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;new technology;Nitric Oxide;Nurse Practitioners;Physician Assistants;Physiological;Physiology;programs;Protocols documentation;Provider;pulmonary function;recruit;Research;Research Personnel;Research Training;Residencies;Rotation;Schedule;Scientist;Services;Shunt Device;Testing;Therapeutic;Therapeutic Intervention;Training;Training Programs;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Walking

PROJECT_TITLE: Pulmonary clinical medicine: PFT lab, bronchoscopy, consultation services, and education


ACTIVITY: ZIG

PI_NAMEs: CLARK, TANNIA  (contact)

PROJECT_TERMS: Accreditation;American;Anesthesia and Analgesia;animal care;Animal Care and Use Committees;Animal Experimentation;Animal Husbandry;animal model development;animal resource;Animals;Area;Behavioral Research;Biomedical Research;Blood;Caring;Child;comparative;Complex;Consultations;Cryopreservation;Derivation procedure;Educational process of instructing;Educational workshop;environmental enrichment for laboratory animals;Floor;Health;Hour;instructor;investigator training;Laboratory Animal Science;Laboratory Animals;Medicine;member;Mentors;Methodology;Microsurgery;Mission;model development;Monitor;Mus;National Heart, Lung, and Blood Institute;Occupational activity of managing finances;Operative Surgical Procedures;outreach program;Phenotype;Postoperative Care;Preparation;programs;protocol development;Publications;radiological imaging;Research;Research Activity;research and development;Research Personnel;Research Support;Resources;Rodent;Services;skills;surgical service;Techniques;Telemetry;Testing;Tissue Banks;Training;Travel;treatment research;ultrasound;United States National Institutes of Health;Work

PROJECT_TITLE: NHLBI Animal Program Division


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SPRINGER, DANIELLE  (contact)

PROJECT_TERMS: Anesthetics;Animal Housing;Animals;Applications Grants;behavior observation;Behavioral;Blood Vessels;Body Composition;Calibration;Cardiac Catheterization Procedures;Caring;Complex;Computer software;Data;data acquisition;Dobutamine;Dose;Echocardiography;Electrocardiogram;Equipment;experience;Experimental Designs;follow-up;Fostering;Frequencies;Goals;Home;Hypoxia;implantation;Indirect Calorimetry;Infusion procedures;Intubation;Knowledge;Lead;Maintenance;Manuscripts;Methods;Modeling;Monitor;mouse model;Movement;Mus;Operative Surgical Procedures;Pharmaceutical Preparations;Phenotype;Physiological;Postbaccalaureate;Postdoctoral Fellow;posters;Preparation;Procedures;Process;programs;protocol development;Protocols documentation;Pulmonary function tests;Research Personnel;Research Support;Resources;Running;Scientist;Services;skills;Stress Tests;Students;System;Technical Expertise;Telemetry;Temperature;Testing;Training;ultrasound;United States National Institutes of Health

PROJECT_TITLE: Murine Phenotyping Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: OAKLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PUBLIC HEALTH INSTITUTE

ORG_STATE: CA

PI_NAMEs: YOUNG HOLT, BETHANY  (contact)

PROJECT_TERMS: Academia;Address;Anti-Infective Agents;Bacterial Vaginosis;Biotechnology;career;Chlamydia;clinical development;Collaborations;Communication;Contraceptive Agents;Contraceptive methods;Contracts;Databases;Development;Discipline;equity, diversity, and inclusion;Event;Funding Agency;Funding Opportunities;Future;Government;Health;HIV;Industry;interest;International;Investments;Knowledge;lectures;Maintenance;Marketing;meetings;Modality;National Institute of Child Health and Human Development;news;novel;outreach;pathogen;Persons;posters;pre-clinical;Prevention;product development;Property;Publications;Research;research and development;Research Personnel;Resources;Services;Technology;technology development;Travel;United States National Institutes of Health;Update;Vagina;webinar

PROJECT_TITLE: NICHD SERVICES: Multipurpose Prevention Technologies (MPT) DATABASE ACCESS AND MAINTENANCE for Contraceptive Research


ADMINISTERING_IC: AI

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung

PROJECT_TERMS: Agreement;Anti-viral Agents;Clinical Research;Clinical Trials;COVID-19;COVID-19 pandemic;COVID-19 patient;Emergency Situation;Evaluation;Funding;Immunomodulators;Infrastructure;Inpatients;interest;Investigational Drugs;medical countermeasure;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;point of care;Research;research study;respiratory;Respiratory Tract Infections;Site;Therapeutic;Vaccination;Veterans Health Administration;Viral

PROJECT_TITLE: VHA -FUNDING FOR SITE COORDINATION OF COVID-19 CLINICAL TRIALS


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: SHOFFSTALL, ANDREW  (contact)

PROJECT_TERMS: Acceleration;Anatomy;Area;Clinical;Computer Models;Cranial Nerves;Data;Data Analyses;data visualization;design;Development;Ensure;Evaluation;experience;Fiber;high resolution imaging;Human;Image;imaging modality;improved;interest;Length;Maps;morphometry;Nerve;Neuroanatomy;neuroregulation;novel;novel therapeutics;Operative Surgical Procedures;Phenotype;Positioning Attribute;Regulation;repository;Resolution;Safety;Sample Size;Site;Tissue Sample;tractography;Translating;vagus nerve stimulation;Vagus nerve structure;Validation;Viscera;Work

PROJECT_TITLE: RECONSTRUCTING VAGAL ANATOMY


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: MCGOVERN, MARK P (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: access disparities;addiction;Address;Adoption;Advocacy;Algorithmic Software;Articulation;Atmosphere;career networking;Categories;Characteristics;Chemistry;Collaborations;Communication;Communities;cost effectiveness;culturally appropriate intervention;Data Collection;Data Element;data infrastructure;data sharing;design;Development;Disease Management;Disparity;Dissemination and Implementation;dissemination science;Economics;Equity;Evaluation;evidence base;Evidence based intervention;experience;Eye;Faculty;Feedback;flexibility;Fostering;Foundations;Funding;Future;Goals;health care delivery;health care quality;health determinants;health disparity;health equity;health inequalities;Heart Research;Helping to End Addiction Long-term;Home;implementation determinants;implementation efforts;implementation research;implementation science;implementation tool;improved;Infrastructure;innovation;Intervention;Intervention Studies;Language;Lead;Leadership;lectures;Logistics;Machine Learning;machine learning model;Maintenance;Maps;marginalization;Measures;Mediation;meetings;member;Mentors;Mentorship;Methods;Modeling;Monitor;multidisciplinary;National Institute of Drug Abuse;National Institute of Mental Health;Needs Assessment;open data;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;organizational structure;overdose prevention;Pain;Pain management;Pain Research;parent grant;Persons;Policies;Policy Maker;Population;Prevention strategy;Process;Productivity;programs;Public Domains;Public Health;Publications;Qualifying;Quality Control;repository;Research;Research Institute;Research Personnel;Resource Sharing;Resources;response;Sampling;scale up;Science;service delivery;Services;social media;Speed;substance use;Substance Use Disorder;symposium;synergism;Taxonomy;tool;treatment research;treatment services;Underserved Population;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;unsupervised learning;Update;user-friendly;web portal;web site

PROJECT_TITLE: HD2A RASC-Administrative Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Poor postpartum health has implications for maternal mortality and infant outcomes. However, eligibility for pregnancy-related Medicaid ends after 60 days postpartum, leading to high rates of postpartum insurance loss. The proposed project evaluates how the Medicaid continuous coverage requirement during the public health emergency affected postpartum coverage, care, and infant care overall, by maternal race-ethnicity, and during various periods of the COVID-19 pandemic context, with implications for state postpartum Medicaid extensions under the American Rescue Plan.

PI_NAMEs: ELIASON, ERICA L (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Affect;American;Award;Birth;Black Populations;career;career development;Caring;Childbirth;Clinical;Contraceptive methods;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Databases;demographics;Department chair;Developed Countries;Development;Discipline of obstetrics;Disparity;disparity reduction;Eligibility Determination;Emergency Medicine;Epidemiology;ethnic disparity;Ethnic Origin;experience;Family;federal poverty level;Freezing;Future;Goals;Gynecology;Health;health care availability;health care disparity;health care service;health disparity;Health Insurance;health outcome disparity;Health Policy;Health Services;Health Services Accessibility;Healthcare;Healthcare promotion;Hispanic Populations;improved;Income;Individual;Infant;Infant Care;Infant Health;infant outcome;Insurance;interest;Link;Low income;Low Income Population;Maternal and Child Health;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Measures;Medicaid;Medicaid eligibility;Medicine;Mentors;Mentorship;Methods;National Institute of Child Health and Human Development;Outcome;pandemic disease;Pediatrics;people of color;Persons;Phase;Policies;poor health outcome;Population Study;postpartum care;Postpartum Depression;postpartum health;Postpartum Period;Pregnancy;Pregnancy loss;prevent;professor;public health emergency;Qualifying;Race;racial disparity;Research;Research Assistant;Research Personnel;Research Priority;Research Project Grants;response;Rhode Island;Risk;Severities;skills;Techniques;Testing;Time;Training;treatment effect;United States;Universities;Variant

PROJECT_TITLE: The Effects of the Medicaid Continuous Coverage Requirement during the Public Health Emergency on Postpartum Coverage and Maternal and Infant Care after Childbirth

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE HIV, cervical cancer and human papillomavirus (HPV) are interrelated health conditions with intersecting stigmas that may influence women’s uptake of prevention services. We will evaluate the effectiveness of a novel stigma-responsive service delivery model for HPV-based cervical cancer screening called “Elimisha HPV” among women in a high HIV-prevalence area of Kenya. If effective, this may serve as a new model for cervical cancer screening as well as a new paradigm for comprehensive, stigma-responsive service delivery packages for people living with HIV.

PI_NAMEs: HUCHKO, MEGAN J. (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Anti-Retroviral Agents;Area;Awareness;Biological;cancer risk;care outcomes;Caring;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Clinic;Collection;Communication;Communities;Community Health;County;Data;design;Diagnosis;Discrimination;Education;Educational Intervention;Educational Materials;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Epidemiology;Focus Groups;follow-up;Fright;Government;Health;Health care facility;Healthcare;HIV;HPV positive;Human Development;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation strategy;implementation/effectiveness;Individual;infection risk;Infrastructure;Institution;Intervention;Interview;Kenya;Language;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurement;Methods;Modeling;novel;Outcome;Outpatients;outreach;Pamphlets;Patient-Centered Care;peer;Perception;Persons;Prevalence;prevent;prevention service;programs;randomized, clinical trials;response;Risk;Risk Factors;screening;Screening for cancer;screening services;service delivery;Service delivery model;Sex Behavior;social stigma;Social support;standard of care;Stigmatization;success;synergism;Testing;Text Messaging;therapy design;tool;Training;treatment arm;uptake;volunteer;Woman;women's outcomes;Work;World Health Organization

PROJECT_TITLE: A stigma responsive service delivery model for HPV-based screening among women living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Patients with Hypersensitivity Pneumonitis experience poor health-related quality of life without access to interventions that target improvement in this outcome. The goal of this proposal is to develop and determine the feasibility and acceptability of a stakeholder-engaged behavioral and educational intervention to improve the health-related quality of life of patients with hypersensitivity pneumonitis. Findings from this innovative pilot randomized trial will lay the groundwork for a future, multi-site, randomized trial testing the effectiveness of the intervention developed here.

PI_NAMEs: ARONSON, KERRI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;American;Antigens;Anxiety;attentional control;Attitude;Behavior Therapy;Behavioral;Benchmarking;career;career development;Chest;Chronic Disease;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive Therapy;Collaborations;coping;design;Development;Development Plans;Disease;Education;Educational Intervention;Educational Materials;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;eHealth;evidence base;experience;Exposure to;Extrinsic allergic alveolitis;Feeling;fibrotic interstitial lung disease;Focus Groups;Foundational Skills;Foundations;Fright;Frustration;Future;Goals;Health;health administration;health related quality of life;Home environment;Hybrids;implementation evaluation;implementation outcomes;implementation science;improved;Infrastructure;innovation;instrument;International;Interstitial Lung Diseases;Intervention;Investigation;Knowledge;Knowledge acquisition;Learning;Life Style;Measures;Medicine;Mental Depression;Mentors;novel;Observational Study;Outcome;Outcomes Research;Participant;Patient Education;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patient-Focused Outcomes;Patients;peer;peer coaching;Peer Group;Persons;pilot test;preference;Protocols documentation;Psychometrics;Qualitative Research;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Design;Research Methodology;Research Personnel;retention rate;Review Literature;Sampling;Scientist;Self Efficacy;Site;skills;Social isolation;Societies;Source;Statistical Data Interpretation;Surveys;System;Testing;theories;therapy development;Thinness;Training;Uncertainty;Universities;Virginia;virtual;Visit;web site;Work

PROJECT_TITLE: Rise-HP: Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis; A Stakeholder Engaged Intervention to Improve Health-Related Quality of Life

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Craniofacial defects are among the most common of all congenital abnormalities. An embryonic population of cells called the neural crest gives rise to a significant portion of the craniofacial complex, including bone and cartilage of the face, pigment cells, and components of the peripheral nervous system. My work seeks to understand how a subfamily of transcription factors (SoxE) help the neural crest form the diversity of cell types in the face and how patient specific SOXE mutations cause Campomelic dysplasia and Waardenburg syndrome.

PI_NAMEs: SCHOCK, ELIZABETH (BETSY)  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: ATAC-seq;Biochemical;Biological Models;Biology;bone;Brightfield Microscopy;campomelic dysplasia;career;Cartilage;Cell Culture Techniques;cell type;Cells;Chick;Chimera organism;Chimeric Proteins;ChIP-seq;Chondrogenesis;Chromatin;clinically significant;Collaborations;Computer Analysis;Congenital Abnormality;Coupled;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;craniofacial disorder;Data Analyses;Defect;Development;developmental disease;directed differentiation;Disease;disease phenotype;DNA Binding Domain;Dominant-Negative Mutation;Embryo;Environment;Etiology;experience;experimental study;Face;Family;Future;gain of function;Gene Activation;Gene Family;Genes;Genetic Transcription;Genome;Genotype;Global Change;Goals;Heterogeneity;Human;Individual;insight;interest;Lead;Link;loss of function;malformation;Measurable;Mediating;melanocyte;Mentors;migration;model organism;Molecular;Morphology;Mutation;Neural Crest;Neural Crest Cell;neurodevelopment;Neuroglia;Neurons;novel;Patients;Peripheral;Peripheral Nervous System;Phase;Phenotype;Pigments;Play;Population;Postdoctoral Fellow;programs;Proteins;Research;Role;screening;SOX8 gene;Specificity;Stains;stem cell population;Syndrome;Tadpoles;Techniques;Tertiary Protein Structure;Time;transcription factor;transcriptome sequencing;Universities;Variant;Vertebrates;Waardenburg syndrome;Work;work-study;Xenopus;Xenopus laevis

PROJECT_TITLE: The Role of SoxE Transcription Factors in Neural Crest Cell Specialization


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rare Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: ANDREWS, JINSY ;BABU, SUMA ;BERRY, JAMES DALE (contact);PAGANONI, SABRINA ;SHEFNER, JEREMY M

PROGRAM_OFFICER_NAME: LYON, DINA MARIE

PROJECT_TERMS: Advocacy;Agreement;Alaska;ALS patients;Amyotrophic Lateral Sclerosis;Award;biobank;Biological Markers;Blood;Brain;Businesses;career;Caregivers;Cell Line;Cells;Clinic;Clinical;clinical center;Clinical Data;clinical investigation;Clinical Research;clinical research site;Clinical Trials;clinically relevant;cohort;Collaborations;Collection;Committee Members;Communication;Communities;community clinic;community engaged research;community engagement;Community Hospitals;community science;Complex;Conscious;Contracts;Critical Pathways;cultural competence;Data;Data Collection;Data Coordinating Center;data harmonization;data portal;data repository;Data Set;Databases;Dedications;design;digital;Digital biomarker;digital data;Disease;diversity and inclusion;Education;Education and Outreach;educational atmosphere;Electronics;empowerment;Enrollment;Ensure;Equity;equity, diversity, and inclusion;evidence base;experience;flexibility;Fostering;Foundations;Funding;Future;Gene Mutation;General Hospitals;Genes;Geography;Grant;Growth;Hawaii;health inequalities;high risk;Home;Human Resources;Image;imaging biomarker;Industry;Infrastructure;innovation;Institutional Review Boards;interest;Investigation;Knowledge;Lead;Leadership;Link;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Mediation;member;Mentorship;Monitor;multimodality;Neurologic;Neurosciences;Nonprofit Organizations;Observational Study;open data;operation;Outcome;Outcome Measure;outreach;Participant;patient engagement;Peripheral Blood Mononuclear Cell;Persons;Population;Population Heterogeneity;Private Practice;Procedures;prospective;Puerto Rico;Readiness;Recording of previous events;recruit;repository;Research;Research Institute;Research Methodology;Research Personnel;response;Risk;Running;Sampling;Scanning;Scholars Program;Science;Scientist;Shoulder;Site;skills;socioeconomic diversity;Socioeconomic Status;socioeconomics;Structure;success;Therapeutic;Time;Training;Training and Education;training opportunity;Underrepresented Populations;underserved area;United States National Institutes of Health;Universities;Vendor;virtual;Washington;Work

PROJECT_TITLE: Access for All in ALS (ALL ALS) East Clinical Coordinating Center


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Rural Health

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PI_NAMEs: BOWSER, ROBERT P (contact);HARMS, MATTHEW ;HARRIS, BRENT T;PHATNANI, HEMALI ;PROVENZANO, FRANK A;SHNEIDER, NEIL ALAN

PROJECT_TERMS: Acceleration;Advisory Committees;ALS patients;Amendment;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Annual Reports;Autopsy;biobank;Biological Markers;Blood;Brain;Budgets;Clinic;Clinic Visits;Clinical;clinical care;Clinical Data;clinical outcome measures;Clinical Research;clinical research site;Clinical Trials;Collaborations;Collection;Common Data Element;Communication;Communities;Community Care Networks;Contracts;Country;Critical Pathways;Data;data curation;data exchange;data integrity;data management;data modeling;data portal;data repository;data resource;Data Set;data sharing;data submission;Databases;Deposition;design;Development;Diagnosis;Digital biomarker;Disease;DNA Sequence Alteration;Documentation;drug development;Educational workshop;effective therapy;end stage disease;Ensure;Equipment and supply inventories;Ethics;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Failure;Family;Foundations;Funding;Funding Agency;Future;Generations;Genome;genome sequencing;genomic data;Geography;Goals;Grant;Healthcare;Home;Hospitals;human error;Human Resources;Image;Improve Access;improved;Individual;Industry;Infrastructure;Institutional Review Boards;International;Knowledge;Laboratories;Leadership;Life;lifetime risk;Link;Location;Longitudinal Studies;Magnetic Resonance Imaging;male;Manuals;Measures;meetings;member;Metadata;Methods;Modeling;Monitor;multimodality;Muscle;mutation carrier;National Institute of Neurological Disorders and Stroke;Natural History;Neurodegenerative Disorders;neuroimaging;Neurologic;New York;Nonprofit Organizations;novel;novel therapeutics;Online Systems;Onset of illness;operation;Outcome Measure;outreach;outreach program;Participant;participant enrollment;patient advocacy group;Patient Participation;Patients;Peer Review;Persons;Phase;Physicians;Population Heterogeneity;Procedures;Process;programs;Protocols documentation;public-private partnership;Quality Control;Race;Records;recruit;Reporting;repository;Request for Applications;Research;research and development;Research Personnel;Research Project Grants;research study;Respiratory physiology;response;Review Committee;Risk;Route;Rural;Rural Community;rural patients;Rural Population;Saliva;Sampling;Schedule;Science;Scientist;Shipping;Site;Specimen;Speech;Spinal Cord;Spirometry;Structure;Subjects Selections;success;Symptoms;System;Tissue Banks;Tissue Procurements;Tissue Sample;Tissues;tool;Training;Training Activity;transcriptome sequencing;transcriptomics;Translating;translational diagnostics;United States;United States National Institutes of Health;Vendor;Vial device;whole genome;women patients;Work

PROJECT_TITLE: Access for All in ALS (ALL ALS) West Clinical Coordinating Center


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: HADDEN-PERILLA, JODI A (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Anti-viral Agents;antiviral drug development;Awareness;Binding;Binding Sites;Biochemistry;Capsid;Capsid Proteins;Chemicals;Core Protein;design;dimer;drug development;Exhibits;fighting;Hepatitis B Virus;Hydrophobicity;inhibitor;Methods;Molecular Conformation;molecular dynamics;novel;Nuclear Export;Nucleosome Core Particle;Peptides;Pharmaceutical Preparations;Phase;Protein Conformation;Public Health;Shapes;small molecule;structural biology;Structure;Therapeutic;therapeutic target;Validation;Viral hepatitis;virology;virtual screening;Virus;Virus Diseases;Virus Inhibitors

PROJECT_TITLE: Molecular dynamics of the HBV capsid to advance the search for antivirals


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetic Testing;Genetics;Human Genome;Pediatric;Pregnancy;Prevention

ORG_DEPT: SURGERY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE The goal of this study is to generate supportive scientific evidence for strategies that will facilitate informed decision-making about PS&D by diverse populations of pregnant patients as early as possible in their prenatal care. By achieving the aims of this study, this study will meet the critical need to provide resources to patients as they consider a changing array of PS&D and post-diagnosis options that have significant implications for their health, their pregnancy, and their family. This study is significant for patient care as it will be a critical step toward establishing patient-centric strategies and resources that can effectively support evidence-based reproductive healthcare in an increasingly complex healthcare setting.

PI_NAMEs: FARRELL, RUTH  (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: abortion;Address;Affect;Birth;care delivery;cell free DNA;Child;Childhood;Clinical;Communities;Complex;Data;Decision Making;Development;Diagnosis;Diagnostic tests;Disparity;Education;Ensure;evidence base;experimental study;Face;Family;fetal;Foundations;Genetic Diseases;Genetic Screening;genetic testing;genome sciences;Genomics;Goals;Growth;Health;health care disparity;health care settings;Healthcare;high risk;improved outcome;Information Centers;innovation;interest;Intervention;Interview;Learning;Maternal-fetal medicine;Measures;Medical;Mendelian disorder;Nature;neonatal outcome;obstetric outcomes;Outcome;Outcome Study;Patient Care;patient oriented;Patient Preferences;patient-level barriers;Patients;Pediatrics;Policies;Policy Maker;Population Heterogeneity;Pregnancy;pregnant;prenatal;Prenatal care;Process;Provider;reproductive;Reproductive Health;Resources;response;Series;Services;Technology;Testing;Time;tool;Work

PROJECT_TITLE: Supporting pregnant patients as they face a changing landscape of prenatal genetic tests and post-diagnosis options


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PI_NAMEs: MOCHONA, BEREKET - (contact)

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Academy;Achievement;Address;Admission activity;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Applied Research;Award;Basic Science;Behavioral;Behavioral Research;Benchmarking;Bioinformatics;Biomedical Research;Biometry;Black Populations;Black race;California;cancer health disparity;Cancer health equity;career;Career Choice;career development;Caring;Clinical;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;cost;Data;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;education research;Educational Activities;Engineering;Ensure;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;Fellowship;Florida;Funding;Genomics;Goals;Government;graduate student;Grant;Health;health care disparity;Health Disparities Research;health equity;Health Professional;Healthcare Systems;higher education;Hispanic;Historically Black Colleges and Universities;Immersion;Impact evaluation;improved;Individual;Institution;interest;International;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Malignant Neoplasms;Manuscripts;medical schools;Medicine;meetings;Mentors;Mentorship;Minority Graduate Student;Minority Groups;minority trainee;Modeling;Monitor;multidisciplinary;Native American Tribe;Oncology;Outcome;Outcomes Research;Patients;peer;Pharmacy facility;Population;Population Research;Postbaccalaureate;Postdoctoral Fellow;posters;pre-clinical;pre-doctoral;Process;Program Evaluation;programs;Public Health;Publishing;Publishing Peer Reviews;Race;racial diversity;recruit;Research;Research Personnel;Research Training;response;Science;Scientist;Site;Structure;Students;success;Training;training opportunity;Training Programs;Training Support;Tribal group;undergraduate student;Underrepresented Minority;United States National Academy of Sciences;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: NARRATIVE: ADMINISTRATIVE CORE The Administrative Core will be the primary touchpoint of the center, facilitating interactions between the two  projects and three additional cores. The Administrative Core will also actively cultivate collaborations throughout  the consortium with assistance from the Outreach Core, particularly through administering Intra-Center and  Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while  enhancing diverse perspectives on this critical topic. Co-PDs Swanson and Canoll will provide the central  leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business,  administrative and scientific management of Center activities.

PI_NAMEs: SWANSON, KRISTIN R (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Administrator;Advisory Committees;Area;Authorization documentation;Award;Biopsy;Businesses;career;clinical imaging;Collaborations;Communication;Communities;Core Biopsy;Data;data access;data integration;data management;data sharing;Discipline;Educational workshop;Ensure;Evaluation;Faculty;Feedback;Funding;Glioma;Grant;Growth;Image;imaging facilities;Institution;interest;Leadership;Logistics;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Mathematics;Monitor;neuro-oncology;Office of Administrative Management;Oncology;outreach;Pathology;Patients;Phenotype;Pilot Projects;Process;programs;Publications;Radiology Specialty;recruit;Reproducibility;Resources;symposium;Systems Analysis;Systems Biology;Tissues;training opportunity;Visit;web site;Work

PROJECT_TITLE: MOSAIC: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

PHR: NARRATIVE: PROJECT 1: TARGETING GLIOMA TISSUE STATES Glioblastoma (GBM) biopsies are composed of not only molecularly aberrant malignant glioma cells but also a  sizeable abundance of non-malignant cells (including immune, astrocytes, oligodendrocytes, etc.). The goal of  this project is to find targetable cross-talk relationships between these cell compositional networks. Specifically,  we will quantify different cellular compositions in pre- and post- treatment tumors, investigate cross-talk between  the glioma cells and the microenvironmental other cell subpopulations, and, lastly, determine the impact of  targeting this crosstalk to shift the cell community composition into a more favorable/treatable state.

PI_NAMEs: TRAN, NHAN L (contact)

PROJECT_TERMS: Acute;Aftercare;anti-PD-L1;Astrocytes;Biological;Biopsy;Bone Marrow;Brain;cell behavior;cell community;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chemoresistance;Conditioned Culture Media;cytokine;Disease Progression;effective therapy;Endothelial Cells;Extracellular Matrix;Genomics;Glioblastoma;Glioma;Goals;Heterogeneity;Image;imaging facilities;Immune;Immunocompetent;Immunotherapy;In Vitro;in vivo;Infiltration;Inflammatory;insight;Interleukin-10;Interleukin-6;Ligands;Macrophage;Magnetic Resonance Imaging;male;Malignant Glioma;Mathematics;Mediating;member;Mesenchymal;Microglia;Modeling;Molecular;Mutation;Myeloid Cells;neoplastic cell;Neurons;Non-Malignant;novel therapeutic intervention;Oligodendroglia;Oncology;Patients;Pattern;Pericytes;Phenotype;Population;progenitor;radiological imaging;receptor;receptor expression;Receptor Inhibition;recruit;Regimen;Role;Sampling;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Slice;Systems Analysis;T-Lymphocyte;temozolomide;Testing;Therapeutic;therapy resistant;Tissues;TNF gene;transcriptome sequencing;Translations;treatment response;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor Necrosis Factor Receptor;tumor progression;Tumor Promotion;women patients;Xenograft Model

PROJECT_TITLE: MOSAIC: Targeting the Tissue State


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PHR: NARRATIVE: PROJECT 2: IMAGING THE DYNAMIC TISSUE STATE IN PATIENTS IN VIVO Magnetic resonance imaging (MRI) measures many different physical properties of the tissue which may be  correlated with the specific tumor behavior (e.g., proliferation, inflammation, angiogenesis) found in the limited  biopsies available per patient. This project will fuse readily available MRI to spatially localized biopsies to build  predictive models of cellular composition across the unsampled tumor (and brain) to track and validate cell composition changes to standard and immune therapies. Connecting these imaging changes to patient survival  will allow identification of clinically beneficial shifts in cellular cohabitation.

PROJECT_TERMS: Adult;angiogenesis;Automobile Driving;Biological Markers;Biopsy;Brain;Brain Neoplasms;Cell model;Cells;Clinical;clinical imaging;cohort;cost;Diagnosis;Disease;Disease Progression;Epidermal Growth Factor Receptor;Facility Accesses;Genomic Segment;Glioblastoma;Glioma;Guidelines;Human;human imaging;human tissue;Image;Image Analysis;imaging facilities;Immune;Immune response;Immune Targeting;Immunocompetent;Immunooncology;Immunotherapy;immunotherapy clinical trials;improved;in vivo;individual patient;individualized medicine;Inflammation;Inflammatory;Magnetic Resonance Imaging;Malignant - descriptor;Mathematics;Measures;Mediating;Modeling;Molecular;Monitor;Nature;neoplastic cell;noninvasive diagnosis;novel;Oncology;Outcome;patient safety;Patient-Focused Outcomes;Patients;Phenotype;physical property;Physiological;Population;predictive modeling;Primary Brain Neoplasms;Proliferating;quantitative imaging;radiomics;Recurrence;Residual Neoplasm;Resources;response;Sampling;Signal Transduction;standard of care;Study models;Systems Analysis;Therapeutic;Time;Tissue Model;Tissue Sample;Tissues;tool;Treatment Protocols;treatment response;tumor;tumor behavior;Work

PROJECT_TITLE: MOSAIC: Imaging Human Tissue State Dynamics In Vivo


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Precision Medicine;Rare Diseases

PHR: NARRATIVE: OUTREACH CORE Getting computational results into the clinic requires a broader understanding of the methods and general  principles by scientists, clinicians, and patients alike. Thus, the primary goal of the Outreach Core is to  disseminate knowledge of the iterative dialogue between mathematical oncology, cancer systems biology and  experimental and clinical oncology to students, colleagues, and the general public. To accomplish our goal, we  will train new cross-disciplinary scientists, inform the research community, engage with the general public, and  assess our outcomes.

PI_NAMEs: JACKSON, PAMELA ROSE (contact)

PROJECT_TERMS: Advocacy;Arizona;Awareness;Biological;Biological Sciences;Biology;Brain Neoplasms;Cancer Biology;cancer education;Cell Physiology;Clinic;Clinical;clinical imaging;Clinical Oncology;clinical translation;Collaborations;Communities;Complex;Computational Science;Consent;design;Discipline;Disease;Education and Outreach;Educational workshop;Engineering;Ensure;experience;Exposure to;Facebook;Family;Future;General Population;Genetic;Glioblastoma;Goals;graduate student;Image;imaging facilities;improved;individual patient;innovation;Institution;Internships;Journals;Knowledge;Language Development;large datasets;Malignant Neoplasms;mathematical learning;mathematical methods;mathematical model;Mathematics;Methodology;Methods;Modeling;neuro-oncology;next generation;novel strategies;Oncology;Outcome;Outcome Assessment;Output;outreach;outreach program;patient advocacy group;Patient Care;Patients;personalized medicine;Postdoctoral Fellow;programs;recruit;Research;Research Project Grants;Scientist;skills;social media;Social Network;Solid;Students;success;summer research;symposium;System;Systems Analysis;Systems Biology;Techniques;Tissues;tool;Training;Twitter;undergraduate student;Universities;Update;web site;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

PHR: NARRATIVE: BIOSPECIMEN CORE The Biospecimen Core will assist the Center through two specific aims: Aim 1) collect and store biopsies, Aim  2) run initial tissue characterization of immunohistochemistry and sequencing. The duties of the Biospecimen  Core Mayo Clinic Arizona (MCA) and Columbia University Medical Center (CUMC) and will support both projects.  The data generated by the Biospecimen Core will be transferred to the Data Integration and Computation Core,  where it will be stored, further processed including batch correction and atlas alignment, and integrated into  computational modeling tools.

PROJECT_TERMS: Academic Medical Centers;Aftercare;Arizona;Atlases;Biology;Biopsy;Cell Lineage;Cells;Clinic;Clinical;Complex;Computer Models;Consent;Data;data integration;Detection;Freezing;gene panel;Glioblastoma;Glioma;Goals;Histologic;Histology;Image;Image Guided Biopsy;imaging facilities;Immunohistochemistry;in vivo;machine learning model;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;mathematical model;Mathematics;Mission;Modeling;Molecular;Molecular Analysis;Oncogenes;Oncology;Operative Surgical Procedures;Paraffin Embedding;Pathology;Patients;Phenotype;Process;radiological imaging;recruit;RNA;Running;Sampling;Scanning;single cell sequencing;single-cell RNA sequencing;Site;Slide;Subgroup;System;Systems Analysis;Tissue imaging;tissue preparation;Tissue Stains;Tissues;tool;Training;transcriptome sequencing;treatment response;Validation

PROJECT_TITLE: MOSAIC: Biospecimen Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: NARRATIVE: DATA INTEGRATION AND COMPUTATION CORE The Data Integration and Computation Core will be central to our Mayo/Columbia CSBC Mathematical  Oncology Systems Analysis Imaging Center (MOSAIC), collecting the diverse data types and sources and providing infrastructure for data resource management of the large datasets relied upon and generated through  the center including those provided by the Biospecimen Core. The Data Integration and Computation Core will support both projects with its three aims: Aim 1) collect and store data across all sites, Aim 2) provide  reproducible bioinformatics workflows, and Aim 3) provide computational modeling tools and techniques.

PI_NAMEs: HAWKINS-DAARUD, ANDREA JEANINE (contact)

PROJECT_TERMS: Authorization documentation;Bioinformatics;Biopsy;Calibration;Cancer Patient;Clinical;Clinical Data;clinical imaging;Clinical Research;Code;Collection;Computer Models;Data;data access;data infrastructure;data integration;Data Management Resources;data sharing;Data Sources;demographics;digital;digital data;Disease;diverse data;Ensure;Generations;genomic data;Glioma;Histology;Home;Hybrids;Image;imaging facilities;imaging Segmentation;in vivo;Infrastructure;innovation;Institution;Institutional Review Boards;large datasets;Location;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of brain;Mathematics;Measurement;Mission;model development;Modeling;Molecular;Oncology;Online Systems;Outcome;Pathology;Patients;predictive modeling;Process;Reporting;repository;Reproducibility;Resources;response;Scanning;Secure;Services;sex as a biological variable;single-cell RNA sequencing;Site;Source;Specimen;Statistical Data Interpretation;Statistical Models;Structure;success;support tools;Systems Analysis;systems research;Techniques;Texture;Tissues;tool;tumor;Work

PROJECT_TITLE: MOSAIC: Data Integration and Computation Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative: Biomaterial-enhanced delivery of chemoimmunotherapies represents a promising strategy to safely target multiple immune resistance pathways and induce direct cytotoxic and immune-mediated tumor control. Here, we will identify and quantify changes in the MHC Class I peptide repertoire with cell-type resolution in a genetically engineered GBM mouse model upon treatment with chemoimmunotherapy regimens and correlate these changes with therapy immunomodulatory mechanisms and survival. MHC peptides upregulated after treatment will be used to develop targeted immunotherapies (e.g., genetically engineered T cells, peptide vaccines) that will significantly enhance the efficacy of chemoimmunotherapy.

PI_NAMEs: WHITE, FOREST M (contact)

PROJECT_TERMS: Address;Adhesives;Adjuvant;Affect;Aftercare;anti-tumor immune response;Antigen Targeting;Antigen-Presenting Cells;Antigens;Biocompatible Materials;Brain Neoplasms;Cell Therapy;cell transformation;cell type;Cells;chemotherapy;Complex;Contralateral;cytotoxic;design;Dinucleoside Phosphates;Doxorubicin;dynamical evolution;engineered T cells;Engineering;Evolution;Genetic Engineering;Genetically Engineered Mouse;Glioblastoma;Hydrogels;Immune;immune checkpoint blockade;immune resistance;Immune Targeting;Immuno-Chemotherapy;immunogenic;Immunologic Adjuvants;Immunologic Memory;immunomodulatory therapies;Immunophenotyping;immunoregulation;Immunotherapy;Implant;in situ vaccination;Injectable;interest;Kinetics;liquid chromatography mass spectrometry;Malignant neoplasm of brain;Mediating;Methods;MHC antigen;MHC Class I Genes;Modeling;mouse model;Mus;nanoparticle;neoplastic cell;Pathway interactions;patient prognosis;peptide I;Peptide Vaccines;Peptides;Periodicity;Regimen;Resistance;Resolution;response;STING agonists;Survival Rate;targeted treatment;Therapeutic;tumor;Tumor Antigens;tumor growth;vaccination strategy;Vaccines;Work

PROJECT_TITLE: Project 2:  Deciphering the Dynamic Evolution of the Tumor-Immune Interface


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project narrative: The importance of the proposed project is to understand the impact of heart failure in venous reflux, chronic venous insufficiency, and venous ulcers. In addition, we need to evaluate the safety of compression therapy in heart failure patients, and the role of compression stockings in preventing advanced venous disease.

PI_NAMEs: CIRES-DROUET, RAFAEL S. (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TITLE: The ROle of Compression StocKings in Heart Failure Patients

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]