ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: FAIRFIELD

ORG_NAME: FAIRFIELD UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The overall goal of this proposal is to identify the influence of healthcare coordination on the association between autism spectrum disorder (ASD) and parent health and stress using a more robust, comprehensive assessment of ASD severity that includes co-occurring conditions, ASD complexity. Further, the role of healthcare coordination will be evaluated in the context of geographic and sociodemographic factors to identify disparities in healthcare access among marginalized and underserved populations. Our central hypothesis is that the degree to which care coordination affects the relationship between ASD complexity and parent outcomes will vary according to sociodemographic factors (i.e., race/ethnicity, rural/urban areas, HPSAs).

PI_NAMEs: PARKER, MICHELE LEANN (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Academy;Accountability;Adverse effects;Affect;Age;American;Area;autism spectrum disorder;autism symptoms;autistic children;Behavioral;care coordination;caregiving;Caring;Child;Child Health;Child health care;Child Rearing;Collaborations;Communication;Communities;Complex;Data;Data Set;Developmental Disabilities;Diagnosis;Disparity;Equation;Ethnic Origin;Exclusion;Factor Analysis;Frequencies;Geographic Factor;Geographic Locations;Geography;Goals;Health;health care availability;health care delivery;health care disparity;health data;health equity;health equity promotion;Health Personnel;health plan;Health Professional;health professional shortage areas;Health Services Administration;Healthcare;Inequity;Investments;Invisible disability;marginalized population;Measurement;Mediation;Medicaid eligibility;Medicaid services;Medical;Mental Health;Mental Health Services;model of autism spectrum disorder;Modeling;Neurodevelopmental Disability;Outcome;Parents;Pediatrics;Personal Satisfaction;Prevalence;Primary Care;primary care provider;Property;Protocols documentation;Provider;Qualifying;Race;Reporting;response;Role;Rural;Sampling;service coordination;Services;Severities;Social isolation;social stigma;sociodemographic factors;sociodemographics;Standardization;Statutes and Laws;Stress;Surveys;Testing;Underserved Population;United States Dept. of Health and Human Services;United States Health Resources and Services Administration;urban area;Variant

PROJECT_TITLE: Autism Complexity and Parental Wellbeing: The Role of Care Coordination in Promoting Health Equity

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Racial and Ethnic Minority Health Research

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This project aims to evaluate racial differences in melatonin concentrations and signaling in human kidney tissue. In addition, racial differences in the density of mitochondria in kidney tissue and the expression of melatonin receptors in these mitochondria will be quantified.

PI_NAMEs: BRUNETTI, LUIGI  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;African American population;African American Women;Antibiotics;Antioxidants;Binding;Biodistribution;Biological;Biological Assay;Cells;Circadian Rhythms;Clinical;Data;density;Development;Disparity;Doctor of Philosophy;Educational workshop;Enrollment;Event;exposed human population;Exposure to;Funding;Gene Expression Profiling;Genetic Transcription;Goals;Grant;Health;Hospitalization;Human;Human body;immune function;Injury to Kidney;Kidney;Knowledge;Maintenance;Measures;Mediating;Melatonin;Melatonin Receptors;Membrane Potentials;Mentors;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Molecular;Molecular Biology;Molecular Biology Techniques;nephrotoxicity;novel marker;nuclear factor-erythroid 2;Nuclear Receptors;Oxidative Stress;parent grant;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Piperacillin-Tazobactam;Placebos;Plasma;post gamma-globulins;pre-clinical;preclinical study;preservation;prospective;Protons;Proximal Kidney Tubules;Qualifying;racial difference;Randomized;Randomized, Controlled Trials;receptor;receptor expression;Receptor, Melatonin, MT2;Research;Research Project Grants;Resources;response;Risk;Risk Reduction;Role;Safety;Serum;Signal Transduction;Source;Stress;Students;targeted biomarker;Techniques;Testing;Time;Tissues;toxicant;Toxicology;Training;transcriptomics;urinary;Urine;Vancomycin;Whole Blood;Work

PROJECT_TITLE: Racial differences in MT1/MT2 receptor expression in human kidneys


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Emergency Care;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Patient Safety;Sepsis

ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Septic shock is the most severe manifestation of sepsis and has a mortality rate above 40%. Unfortunately, existing sepsis research is limited by poorly understood variation and heterogeneity within septic shock patient populations. This study innovatively combines electronic health record and genetic data to improve the care of critically ill Emergency Department patients with septic shock, and addresses disparities in racial representation present in prior research.

PI_NAMEs: BLACK, LAUREN PAGE (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Accident and Emergency department;Address;advanced analytics;analytical method;biobank;biomedical informatics;black patient;career development;Characteristics;Classification;Clinical;clinical decision support;clinical translation;clinically relevant;cost;Critical Care;Critical Illness;Data;Data Science;Data Set;Death Rate;design;Disparity;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Medicine;Enrollment;experience;Genes;Genetic;Genetic Polymorphism;Heterogeneity;Hospitals;Hypotension;implementation science;improved;innovation;insight;K-Series Research Career Programs;Liquid substance;Mentors;Mentorship;Methods;Modeling;mortality;novel;Outcome;patient population;Patients;Pharmacogenetics;Pharmacogenomics;Phenotype;Public Health;Race;racial disparity;Refractory;Research;Research Personnel;research study;response;Resuscitation;risk variant;safety net;Sampling;Sepsis;septic patients;Septic Shock;Shock;Single Nucleotide Polymorphism;skills;Training and Education;treatment response;unsupervised learning;Variant;Vasoconstrictor Agents;Work

PROJECT_TITLE: Informing the Emergency Care of Septic Shock Patients: A Novel Application of Data-Driven Analytics

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: NARRATIVE The proposed research aims to understand how the EPHA2 cell surface receptor integrates both mechanical and biochemical cues from the tumor microenvironment to regulate tumor progression and metastasis via its canonical and non-canonical signaling mechanisms in cancer cells. Results from this research could lead to new approaches to inhibit tumor metastasis.

PI_NAMEs: PASQUALE, ELENA B (contact);YANG, JING

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Biochemical;Biological Assay;Breast Cancer Cell;breast cancer progression;cancer cell;cancer invasiveness;Cell Surface Receptors;Cues;EPHA2 gene;EphA2 Receptor;Epithelium;Extracellular Matrix;in vivo;Invaded;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;mechanical force;Mechanics;mechanotransduction;Mesenchymal;Neoplasm Metastasis;novel strategies;Play;Receptor Signaling;Research;response;Role;Signal Transduction;three dimensional cell culture;tumor;Tumor Cell Invasion;tumor microenvironment;tumor progression;Xenograft Model

PROJECT_TITLE: EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: Prenatal alcohol and anxiety: an ontogenetic role for CRF Prenatal exposure to alcohol differential affects anxiety across the lifespan and increases ethanol consumption, yet the neurobiological underpinnings are not well understood. The corticotropin- releasing factor (CRF) system is heavily involved in regulating anxiety and ethanol intake through its actions in the medial central amygdala (CeM) and is disrupted by prenatal exposure to alcohol. This proposal will examine prenatal alcohol-induced adaptations in the CRF system within the CeM across ontogeny to determine how dynamic changes in this system contribute to fluctuations in anxiety-like behaviors and ethanol intake.

PI_NAMEs: DIAZ, MARVIN RAFAEL (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Acute;Adolescent;adolescent alcohol exposure;adolescent offspring;Adult;Adult women;Affect;Age;age related;Agonist;Alcohol abuse;alcohol abuse during pregnancy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety-like behavior;anxiety-related behavior;Behavior;Behavioral;Blood;Brain;Brain region;Cells;Central Medial Thalamic Nucleus;Child;Childhood;Corticotropin-Releasing Hormone;Coupling;Data;Development;Electrophysiology (science);Emotional;epidemiologic data;Ethanol;Exposure to;Female;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;gamma-Aminobutyric Acid;Growth;GTP-Binding Proteins;Human;Impairment;In Vitro;in vivo;Individual;Infusion procedures;innovation;Investigation;Life;life span;Long-Term Effects;male;Male Adolescents;Marble;Measures;Medial;Mediating;Messenger RNA;Microinjections;Modeling;neurobiological mechanism;Neurobiology;neurogenesis;neuromechanism;novel;novel therapeutic intervention;offspring;Pathway interactions;Pattern;Phase;Phenotype;Population;preference;Pregnancy;prenatal;Prevalence;Proxy;Rattus;receptor;Risk Taking;Role;sex;Sex Differences;showing emotion;Signal Transduction;Site;Stress;Structure;Synapses;Syndrome;System;Testing;Time;transmission process;vapor

PROJECT_TITLE: Prenatal Alcohol and Anxiety: An Ontogenetic Role for CRF

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Our proposal for Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next- Generation Human Neuroimaging Research and Beyond (REACH for BRAIN) will utilize community engagement with Black and Latinx stakeholder networks, to co-create evidence-based solutions and ethical guidance to expand the inclusiveness of participation in NIH BRAIN research and human neuroimaging studies more broadly. Utilizing a stakeholder network, Outcome Map, and Theory of Change (ToC) already established in pilot work, and initially targeting recruitment for research with the BRAIN Initiative supported Connectome 2.0 project, community members, neuroscientists, and neuroethics experts will co-develop and implement a targeted, community-led and participant-centered deliverables to increase the participation of underrepresented and minoritized groups in neuroimaging research. Given the fraught history of scientific racism and biological essentialism in brain science, Aim 1 efforts to create appropriately diverse participation in neuroimaging will be accompanied by the Aim 2’s creation of Working Group consensus guidance and applied tools to guide neuroimaging researchers on how to measure and report on participants’ sociodemographic identifiers.

PI_NAMEs: HUANG, SUSIE YI;JACKSON, JONATHAN DAVID;SHEN, FRANCIS X (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Anatomy;Behavior;Biological;Black race;Boston;Brain;Brain imaging;BRAIN initiative;brain research;Categories;clinical application;Cognition;Communities;community engaged research;community engagement;Community Health;connectome;Consensus;Data;Data Element;Data Set;data sharing;Decision Aid;Dedications;demographics;Development;Disease;diversity and inclusion;Education;Enrollment;essentialism;Ethics;Ethnic Origin;Evaluation;Event;evidence base;Foundations;Funding;Genetic;Glean;Goals;Guidelines;Health;health equity;Human;Human Resources;Imaging technology;implementation framework;improved;Individual;Informed Consent;innovative neurotechnologies;interest;Intervention;Joints;Journals;Justice;Latinx;Learning;Literature;Magnetic Resonance Imaging;Maps;Measures;member;minority communities;Minority Groups;Modeling;neural;neuroethics;neuroimaging;Neuronal Plasticity;Neurosciences;Neurosciences Research;neurotechnology;next generation;novel;Outcome;Ownership;Participant;Pathway interactions;Population Heterogeneity;Process;Professional Organizations;Publications;Race;racism;Recording of previous events;recruit;Reporting;repository;Research;Research Personnel;Research Project Grants;Sampling;Science;Shapes;sociodemographics;Speed;Structure;symposium;Technology;technology development;technology validation;Theory of Change;Tissues;tool;Underrepresented Populations;United States National Institutes of Health;Variant;web site;Work;working group

PROJECT_TITLE: Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ALACHUA

ORG_NAME: NANOTHERAPEUTICS, INC.

ORG_STATE: FL

PI_NAMEs: TOMIC, MILAN  (contact)

PROJECT_TERMS: Advanced Development;biodefense;candidate selection;Chemistry;Clinical assessments;Communicable Diseases;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;medical countermeasure;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Advanced Development of Medical Countermeasures for Infectious Diseases


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

PHR: Development of therapy for spinal cord injury

PI_NAMEs: BARNES, KEITH  (contact)

PROJECT_TERMS: absorption;Alzheimer's Disease;Area;Biological Assay;Chemistry;computational chemistry;Computer Assisted;Contractor;Contracts;design;Drug Compounding;drug discovery;Enzymes;Excretory function;In Vitro;Logistics;Metabolism;National Institute of Neurological Disorders and Stroke;novel;novel therapeutics;Parents;Performance;Performance at work;Pharmaceutical Chemistry;Phase;pre-clinical;programs;Services;Shipping;small molecule;Spinal cord injury;Structure-Activity Relationship;therapeutic development;therapy development;Toxicology;United States National Institutes of Health;Work

PROJECT_TITLE: MCSP - EXPLORATORY CHEMISTRY (EC)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Human Genome;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Many anticancer drugs have adverse effects on the heart and vascular system, making cancer survivors vulnerable to cardiovascular decline. By studying drug-induced changes in gene expression in cardiac organoids, I will identify specific cell types, genes, and alleles that are important for cardiotoxicity risk. Identification of risk factors and biomarkers may ultimately allow clinicians to provide cancer patients with safer and more effective treatment options.

PI_NAMEs: MCINTIRE, ERIK  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acute;Adverse effects;Affect;Alleles;Anthracycline;anti-cancer treatment;Antineoplastic Agents;Arrhythmia;bevacizumab;Biological Markers;Biological Models;Blood Vessels;Cancer Patient;Cancer Survivor;cancer therapy;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Catalogs;Cell Culture Techniques;Cell Differentiation process;Cell Line;cell type;Cells;Cessation of life;Classification;clinical phenotype;Data;differentiation protocol;Disease;disorder risk;Doxorubicin;Drug usage;effective therapy;Embryoid bodies;Endoderm;Endothelial Cells;Environment;experimental study;Fibroblasts;Fluorouracil;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic architecture;Genetic Transcription;genetic variant;Genotype;genotyped patients;Heart;Heart failure;Heritability;Hypertension;improved;Individual;individual patient;induced pluripotent stem cell;inter-individual variation;Intuition;Long-Term Effects;Malignant Neoplasms;Maps;Measures;Mediating;Mesoderm Cell;Modeling;Morbidity - disease rate;mortality;Neural Crest Cell;novel;Oncology;Organoids;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Predisposition;premature;Primitive foregut structure;Procedures;Reporting;Reproducibility;response;Risk;Risk Factors;Sample Size;Sampling;side effect;single-cell RNA sequencing;stem cells;Supporting Cell;Symptoms;System;Testing;Time;Tissues;Toxic effect;trait;Transcript;transcriptomics;Treatment Protocols;Variant;Vascular Endothelial Cell;Vascular System;Work

PROJECT_TITLE: Single-Cell RNA Sequencing of Cardiac Organoids to Determine the Genetic Basis for Cell-Specific Responses to Anticancer Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: CORVALLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: RELEVANCE (See instructions): Optimizing the dose of epilepsy medication to suppress seizures and minimize side effects can be an ongoing struggle. Although knowing the drug's level in the body would be expected to help guide dosing, laboratory measurement of drug levels in blood is inconvenient and slow. We propose to create and validate a device that could be used by a patient to measure (using chemical sensing and Al) the drug level in their saliva in order to rapidly find their optimal dosing plan and improve their quality of life.

PI_NAMEs: FU, ELAIN ;JOHNSTON, MATTHEW L;RAMSEY, STEPHEN A. (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;Anticonvulsants;Biological Assay;Blood;Blood specimen;Caregivers;Chemicals;Chronic;Clinical;computerized tools;Data Science;Devices;Disease;Dose;Drug Kinetics;Drug Monitoring;drug testing;Electrochemistry;Electronics;Ensure;Epilepsy;Equity;Feedback;Home;improved;innovation;Instruction;Knowledge;Laboratories;Machine Learning;Measurement;Measures;microelectronics;Mission;National Institute of Biomedical Imaging and Bioengineering;non-invasive system;Patients;personalized therapeutic;Persons;Pharmaceutical Preparations;pharmacokinetic model;precision drugs;Quality of life;Reporting;Research;Research Project Grants;Saliva;Salivary;Sampling;Science;Seizures;side effect;student training;System;Systems Development;Systems Integration;technology development;Testing;Time;Titrations;tool;Variant

PROJECT_TITLE: SCH: Toward a smart, home-use system for noninvasive, personalized monitoring of drug levels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


NIH_SPENDING_CATS: Clinical Research;Data Science;Patient Safety;Pediatric;Prevention

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: UNIVERSITY OF BOTSWANA

PHR: Public Health Relevance Statement This research explores the ethical, legal, and policy issues of using electronic health records and linking genomic data in African pediatric research. The findings will inform policies and practices to protect children and improve ethical data use in African healthcare advancements.

PI_NAMEs: KYOBE, SAMUEL ;RETSHABILE, GAONE  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Administrative Supplement;Adult;adverse outcome;Africa;African;Age;Agreement;Bioethical Issues;Bioethics;Botswana;Caring;Child;Child Health;Child Welfare;Childhood;Cognitive;Collaborations;Collection;Communities;Complex;complex data;Consent;Country;Data;data anonymization;Data Collection;data complexity;Data Linkages;Data Science;data sharing;Development;Discipline;Electronic Health Record;Ensure;Ethics;evidence base;evidence based guidelines;experience;experimental study;Funding;Future;genomic data;Genomics;Health;health record;Healthcare;HIV;improved;Informed Consent;innovation;insight;instrument;Interview;Knowledge;Legal;legal implication;Link;Medical Research;Methodology;Methods;Multiomic Data;Nature;non-genomic;Outcome;Parental Consent;parental involvement;Parents;Participant;Patients;pediatric human immunodeficiency virus;Pediatric Research;Pediatrics;personalized intervention;Phenotype;Policies;policy implication;Policy Maker;Population;preference;Privacy;Process;programs;public health relevance;Recommendation;Research;Research Design;Research Personnel;Research Support;risk prediction;Safety;Scientific Advances and Accomplishments;Security;stem;Structure;Subgroup;Surveys;Uganda

PROJECT_TITLE: DSpace: Utilizing Data Science to Predict and Improve Health Outcomes in Pediatric HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Cystic Fibrosis;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: public health relevance as it relates to the mission of NHLBI, as cystic fibrosis  (CF) is a degenerative lung disease prominent in children that leads to decreased quality of life and  reduced life expectancy. The development of a smart sensor system that noninvasively monitors  CF-induced pulmonary exacerbations (PEx) in real-time will enable at-home testing solutions, lower  healthcare costs, reduce misdiagnosis/overtreatment, and improve clinical outcomes for CF patients.

PI_NAMEs: AGARWAL, MANGILAL  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: accurate diagnosis;Address;Affect;Antibiotics;Artificial Intelligence;Basic Science;Biological Markers;biomarker identification;biomarker panel;Biometry;biosignature;Biotechnology;Bluetooth;Body Weight decreased;Breath Tests;candidate marker;Caregivers;Cellular Phone;Chemistry;Child;children with cystic fibrosis;Clinic;Clinical;Collaborations;Communication;computing resources;cost;Coughing;Cystic Fibrosis;cystic fibrosis patients;Data;Data Collection;design;Detection;Development;Devices;Diagnosis;diagnostic development;Discipline;Engineering;Ensure;Equipment;Exhalation;experience;Family;frontier;Genetic Diseases;Goals;Health;Health Care Costs;Heart Diseases;Home;home test;improved;Instruction;Interdisciplinary Study;interest;Intravenous;Knowledge;Laboratories;Life Expectancy;Lung;Lung Diseases;Machine Learning;machine learning algorithm;Mass Fragmentography;Medical;Medicine;Metabolic Pathway;Mission;Monitor;nanosensors;National Heart, Lung, and Blood Institute;non-invasive monitor;non-invasive system;novel marker;Outcome;overtreatment;Patients;Persons;point of care;Production;prototype;Public Health;Public Health Informatics;public health relevance;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;Qualifying;Quality of life;Recovery;remote diagnosis;Research;Research Activity;research clinical testing;Research Support;Resolution;Resources;Sampling;sensor;Severities;smart device;smartphone application;Sputum;Statistical Data Interpretation;Symptoms;System;Technology;Testing;Time;Translating;transmission process;treatment response;United States;user-friendly;volatile organic compound;wireless communication

PROJECT_TITLE: SCH: Smart Breath- based Diagnosis of Pulmonary Exacerbations in Children with Cystic Fibrosis through Machine Learning: Towards Noninvasive Health Monitoring in Real-Time


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Hematology;Nanotechnology;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research;Wound Healing and Care

ORG_CITY: LAS VEGAS

ORG_NAME: FIBROPLATE, INC.

ORG_STATE: NV

PHR: PROJECT NARRATIVE Radiotherapy disrupts the physiological process of wound healing. Impaired wound healing in oncologic patients undergoing radiotherapy after surgery is associated with chronic ulceration, infections, and surgical morbidity. Fibroplate is developing a new biological treatment that could be safely and easily administered to accelerate wound healing in irradiated breast cancer patients.

PI_NAMEs: YEN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: Acceleration;Acute;Adjuvant Radiotherapy;Adverse effects;Affect;Albumins;Animal Model;Animals;Anthracycline;Biological;Biological Products;Biological Response Modifier Therapy;Biopsy;Blood Platelets;Blood Vessels;Body Weight;Bone Marrow;Bone Marrow Cells;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Cancer Treatment;Cancer Model;Cancer Remission;cancer therapy;Carboplatin;CD34 gene;Cells;chemotherapy;Chronic;chronic ulcer;chronic wound;Clinical;Clinical Management;clinical practice;Coagulation Process;Combined Modality Therapy;Control Groups;cytokine;Dose;Drug Interactions;Effectiveness;efficacy validation;endothelial stem cell;Environment;Evaluation;experience;Extravasation;Fibrinogen;Fibroblasts;healing;Health;Hemorrhage;Hemostatic function;histological studies;Hospital Costs;Human;hyperbaric chamber;Immunocompromised Host;Impaired wound healing;improved;In Vitro;Infection;Inflammatory;Injectable;innovation;Intravenous;Intravenous infusion procedures;intravenous injection;irradiation;Knowledge;Label;Legal patent;Life;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammaplasty;Marketing;Mastectomy;Metastatic breast cancer;Methods;Miniature Swine;Modeling;Monitor;Morbidity - disease rate;Mus;Nanosphere;neovascularization;operation;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;PECAM1 gene;Pericytes;Pharmaceutical Preparations;Phase;Physiological Processes;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Procedures;Process;Production;Quality of life;Radiation;Radiation induced damage;Radiation therapy;Radiodermatitis;Rattus;re-epithelialization;Recurrence;Residual Neoplasm;revascularization;Risk;Safety;Saline;side effect;Site;Skin injury;skin lesion;skin ulcer;Small Business Innovation Research Grant;soft tissue;Solid Neoplasm;stem cells;Supportive care;Surgical wound;Survival Rate;Therapeutic Uses;Time;tissue regeneration;Transfusion;tumor;tumor microenvironment;Ulcer;Validation;Work;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Fibrinogen-coated albumin nanospheres for mitigation of irradiation-induced wound healing impairment in breast cancer patients.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Cancer is a frequent diagnosis in the emergency department (ED); ED cancer diagnoses are more common among racial minorities and low-income patients and result in poor outcomes, including lower survival. Evidence about emergency diagnosis of lung cancer in the United States (U.S.), and how to prevent it from occurring, is limited. This supplement will generate much needed evidence about emergency diagnosis of lung cancer, focusing on associations and outcomes among patients with chronic obstructive pulmonary disease, and predictors of survival to help identify modifiable drivers of disparities in patients with the poorest prognoses.

PI_NAMEs: THOMPSON, CAROLINE AVERY (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;Affect;African American;beneficiary;cancer diagnosis;cancer epidemiology;Cancer Patient;cancer risk;cancer therapy;Cause of Death;Characteristics;Chronic Obstructive Pulmonary Disease;comorbidity;Critical Care;Data;Development;Diagnosis;Diagnostic Neoplasm Staging;Disadvantaged;Disparity;Emergency department visit;Emergency Situation;Ethnic Origin;frailty;Funding;Grant;Guidelines;health care service;health care service utilization;Health Services Research;Instruction;Link;Low income;low socioeconomic status;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;Medicine;Newly Diagnosed;Outcome;parent grant;Patients;Population Study;Positioning Attribute;Postdoctoral Fellow;prevent;Prognosis;Publications;Race;racial minority;Research Personnel;SEER Program;Severities;Severity of illness;skills;Smoking;smoking-related disease;Socioeconomic Status;socioeconomics;Stage at Diagnosis;survival prediction;Time;Training;United States

PROJECT_TITLE: Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities - Diversity Supplement


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Excessive alcohol use contributes to a wide range of negative health outcomes, including accidents, violence, alcohol dependence, and cardiovascular disease. Existing interventions to reduce alcohol use may not be appropriate for TNB people, both due to inapplicable and potentially unacceptable content (e.g., gender- specific drinking guidelines) and because they do not address anti-TNB stigma as a key determinant of alcohol use in this population. Relationship-focused interventions have the potential to jointly address alcohol use and co-occurring depression/anxiety symptoms in TNB people by reducing adverse relationship experiences (e.g., intimate partner violence) that result from stigma—and leveraging supportive romantic relationships as a buffer against the effects of stigma.

PI_NAMEs: MURCHISON, GABRIEL R (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Accidents;Address;Adult;Advocacy;Affect;Alcohol consumption;Alcohol dependence;alcohol intervention;Alcohols;Anxiety;anxiety symptoms;arm;Attenuated;Buffers;Cardiovascular Diseases;career;Clinical;Communities;community engaged intervention;community engagement;Data;Data Collection;Data Set;design;Development;diaries;Discrimination;drinking;Educational workshop;efficacy trial;Epidemiologist;Epidemiology;Evaluation;experience;Factor Analysis;Feasibility Studies;Feedback;Future;Gender;Goals;Guidelines;Health;improved;Intervention;Interview;intimate partner violence;Link;Measurement;Measures;Mediating;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Modeling;motivational enhancement therapy;nonbinary;online intervention;Outcome;Performance;Persons;Phase;Population;Process;Property;prospective;prototype;Psychometrics;Qualitative Methods;Qualitative Research;reduced alcohol use;Reporting;Research;Risk Factors;Role;satisfaction;Scientist;Series;Sexual and Gender Minorities;Shapes;Social Identification;social stigma;sound;Structure;Surveys;technology intervention;technology validation;Testing;therapy development;Training;transgender;usability;Violence;violence victimization;Work;young adult;young adult alcohol use

PROJECT_TITLE: Stigma,Romantic Relationships, and Alcohol Use Among Transgender and Nonbinary Young Adults

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

PHR: NARRATIVE Randomized controlled trials demonstrated a reduction in lung cancer mortality with annual lung cancer screening with low dose computed tomography, yet real-world populations eligible for and undergoing lung cancer screening differ substantially from trial populations. By leveraging data from a randomized controlled trial and multiple real-world data sources, the proposed study will evaluate the benefits and harms of lung cancer screening in clinical practice settings with a focus on optimizing internal and external validity by applying novel causal inference methodologies. The proposed research is consistent with the Cancer Moonshot Initiative of the National Cancer Institute, which issued a call to action on cancer screening and early detection in February 2022.

PI_NAMEs: HENDERSON, LOUISE ;LUND, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adherence;Affect;Behavioral;Behavioral Risk Factor Surveillance System;Breast Cancer Detection;cancer therapy;Characteristics;clinical practice;Clinical Trials;colon cancer screening;Communication;cost;Data;Data Set;Data Sources;Decision Aid;Decision Making;design;Development;Diagnostic Procedure;Early Diagnosis;Effectiveness;Eligibility Determination;Equilibrium;evidence base;Female;follow-up;General Population;human old age (65+);improved;Individual;Intervention;intervention effect;Left;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medicare claim;Methodology;Methods;mortality;National Cancer Institute;National Health Interview Survey;North Carolina;novel;Observational Study;Outcome;Outcome Assessment;Patients;Pattern;Policy Maker;Population;Population Characteristics;practice setting;Procedures;Provider;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Registries;Research;Research Personnel;Risk Factors;routine screening;Sampling;screening;Screening for cancer;screening guidelines;screening program;Selection Bias;Selection for Treatments;shared decision making;Smoking;Subgroup;Surveys;Time;tool;trial enrollment;United States Preventative Services Task Force;Update;uptake;Work

PROJECT_TITLE: Applying causal inference methods to improve estimation of the real-world benefits and harms of lung cancer screening - NCI Diversity Supplement

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: LI, SHUO  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Algorithms;Area;Artificial Intelligence;Assessment tool;Atherosclerosis;Awareness;Biomedical Engineering;Biomedical Research;Blood Pressure;blood pressure control;Blood Tests;Calcium;Calibration;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Clinical;clinical practice;clinical predictors;Clinical Research;clinical risk;computer science;Contrast Media;Coronary;coronary calcium scoring;cost;Cost of Illness;Data Science;Data Set;Demographic Factors;Dependence;Development;Discrimination;diverse data;Event;Fatty acid glycerol esters;Feedback;Fingerprint;Foundations;Guidelines;Health;Health Personnel;Healthcare Systems;heart dimension/size;Heart failure;high risk;Image;Image Analysis;image processing;improved;insight;Instruction;Knowledge;Label;Learning;learning strategy;Literature;Machine Learning;Measurement;Modeling;multitask;Myocardial Infarction;novel;Outcome;Pathogenesis;Patient Care;Patients;Play;predictive modeling;Prevention strategy;Preventive therapy;Race;Radiation;Recommendation;Reproducibility;Research;Research Personnel;Residual state;responsible artificial intelligence;Risk;Risk Assessment;risk prediction;risk prediction model;Role;Science;screening program;sex;SMART health;social;Socioeconomic Status;Specific qualifier value;Standardization;Stroke;Subgroup;Techniques;Time;transfer learning;Trust;trustworthiness;Uncertainty;usability;user-friendly;Validation;Vascular calcification;Work;X-Ray Computed Tomography

PROJECT_TITLE: SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction


NIH_SPENDING_CATS: Bioengineering;Cancer;Lung;Lung Cancer

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: NARRATIVE Darwinian evolution drives the emergence of resistance to targeted therapy in cancer. We propose to use results from our in vitro evolutionary game assay to parameterize a computer model to allow us to predict 3-dimensional dynamics on clinically relevant timescales. Further, we will extend our assay to function in vivo, allowing the community to test mathematically derived evolutionary therapy hypotheses in preclinical models.

PI_NAMEs: MARUSYK, ANDRIY ;SCOTT, JACOB GARDINIER (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;abiraterone;actionable mutation;Address;anti-cancer research;Antibiotic Resistance;Automobile Driving;Biological;Biological Assay;Biological Process;Biology;Cancer Model;cancer therapy;Clinic;Clinical;Clinical Medicine;clinical translation;Clinical Trials;clinically relevant;Code;Communities;Complex;Computer Models;Data;design;Disease;Ecosystem;Epidermal Growth Factor Receptor;Evolution;Exhibits;experience;Extinction;Favorable Clinical Outcome;Fisheries;Game Theory;Generations;Genes;Glean;Grain;Growth;Heterogeneity;in silico;In Vitro;in vitro Model;in vivo;inhibitor;insight;interdisciplinary approach;Intuition;invention;Life;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Mathematics;Measurement;Measures;Methods;Modeling;multi-scale modeling;mutant;Mutation;neoplastic cell;New Agents;next generation;Non-Small-Cell Lung Carcinoma;novel;pathogen;Patients;Pesticides;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;physical science;Population;Population Heterogeneity;Pre-Clinical Model;pressure;Process;Protein Tyrosine Kinase;Proteins;Qualitative Methods;Race;Refractory;Relapse;Research;Resistance;response;Role;spatiotemporal;success;System;targeted cancer therapy;targeted treatment;Testing;Theoretical model;Theoretical Studies;theories;Therapeutic;Therapeutic Intervention;therapy design;Time;tool;Translating;trial design;tumor;two-dimensional;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Teenage Pregnancy;Women's Health Research

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Adolescent females detained or on probation in juvenile justice settings present with a unique health risk profile, including elevated risk of unplanned pregnancy, substance use, HIV/STI infection, and the overlapping risk of substance-exposed pregnancy. This study will test the efficacy of a targeted bundled prevention intervention for this vulnerable population, many of whom are ethnic minorities disproportionately at risk.

PI_NAMEs: PARRISH, DANIELLE ELIZABETH (contact);VON STERNBERG, KIRK

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Address;Adolescent;adolescent woman;Adult women;Affect;Alcohol consumption;alcohol exposure;alcohol risk;alcohol risk reduction;Alcohols;Behavior;behavior change;Behavior Therapy;Behavioral;Cognitive;Communities;Conceptions;condoms;consistent condom use;Criminal Justice;design;Development;Diversion Program;efficacy evaluation;efficacy testing;efficacy trial;ethnic minority;Ethnic Origin;Female;Female Adolescents;Female of child bearing age;follow-up;Gender;Goals;Health;Health behavior change;high risk;High Risk Woman;HIV;improved;Individual;Infection;infection risk;Informal Social Control;Intervention;Journals;Justice;juvenile justice system;Low Prevalence;male;Marijuana;marijuana cessation;marijuana use;Mediating;Mediator;Minority;Mobile Health Application;Motivation;motivational enhancement therapy;Nature;nicotine use;peer;Pilot Projects;Population;post intervention;Pregnancy;pregnant;prevent;preventive intervention;probation;Process;programs;Public Health;Race;racial diversity;racial population;Readiness;Recording of previous events;reduced alcohol use;Reporting;Research;Risk;Risk Behaviors;Risk Reduction;Services;sexual risk behavior;sexually active;Sexually Transmitted Diseases;skills;societal costs;standard care;substance use;substance use prevention;Teenagers;Testing;Theoretical model;therapy design;Time;Tobacco;Underserved Population;unintended pregnancy;Vulnerable Populations;web site;Woman;Work;young woman;Youth

PROJECT_TITLE: CHOICES-TEEN: Efficacy of a Bundled Risk Reduction Intervention for Juvenile Justice Females

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Cerebral edema is the deadliest consequence of traumatic brain injury (TBI), but current therapeutic interventions are only modestly successful – likely because our understanding of the basic mechanisms underlying edema remain incomplete. If successful, our results could prompt a reassessment of how we treat TBI related edema, with a focus on treating excitability as well as swelling after the event. Moreover, our studies will provide the basis for rational approaches for targeted treatments during the critical hours and days following TBI.

PI_NAMEs: POKAM, PUNAM ADHIK (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Affect;Alcian Blue;Anions;Astrocytes;Biophysics;Blood Vessels;Brain Injuries;Cations;Cause of Death;cell type;Cells;Cerebral Edema;chloride-cotransporter potassium;Chlorides;Clinical;Complex;controlled cortical impact;Data;Development;Down-Regulation;Drug Targeting;Edema;Electric Capacitance;Elements;Equilibrium;Event;extracellular;Extracellular Matrix;Failure;Female;GABA Receptor;Gel;Gelatinase B;Genetic;genetic manipulation;Glutamates;Goals;Histological Techniques;Homeostasis;Hour;Image;Impairment;in vivo;in vivo two-photon imaging;Injury;insight;Intervention;Label;Link;male;Matrix Metalloproteinases;Mediating;Mediator;Membrane;Membrane Potentials;mild traumatic brain injury;Monitor;Morbidity - disease rate;mortality;Movement;Mus;neuronal excitability;Neurons;novel;Outcome;Pattern;Population;Potassium;Predisposition;Process;protective effect;Publishing;Receptor Activation;Recovery;Regulation;Resistance;Resolution;response;reuptake;Role;Seizures;severe injury;Sex Differences;Shapes;Stains;success;Swelling;synaptic inhibition;Testing;Therapeutic Intervention;therapeutic target;Time;tool;transmission process;Traumatic Brain Injury;two photon microscopy;two-photon;Up-Regulation;Water;Water Movements;Whole-Cell Recordings;Work

PROJECT_TITLE: The dynamic balance between neuronal volume and chloride handling in network excitability after traumatic brain injury

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: PEDIATRICS

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE – OVERALL The Universities, Hospitals and Community Organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Using the targeted resources of an IDeA-CTR Award, the Brown Institute for Translational Sciences, and a statewide consortium of collaborators, hospitals, universities, non-profit organizations and government agencies, will draw on the resources already developed in the NIH Institutional Development Award (IDeA) programs (core labs and faculty development programs) to enhance the Advance Clinical and Translational Research Program’s (Advance-CTR) ability to support clinical and translational research. We will serve as a bench-to-bedside research network and career development umbrella for the investigator community in affiliated institutions. In so doing, we will enhance patient-centered research and accelerate discoveries and health innovations to benefit our communities and to serve our State.

PI_NAMEs: ROUNDS, SHARON IRENE SMITH (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Area;Award;Basic Science;bench to bedside;Big Data;Biological;biomedical informatics;Biometry;career;career development;Caring;Clinical;clinical application;Clinical effectiveness;clinical infrastructure;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community engaged research;community engagement;Community Mental Health Services;community organizations;Community Outreach;Core Facility;cost;COVID-19;Data;demographics;Development;Discipline of Nursing;Education;Environment;Epidemiology;Evolution;Extramural Activities;Fostering;Funding;Funding Opportunities;Future;Goals;Government Agencies;Grant;Health;health care delivery;health disparity;health equity;Health Policy;Health Priorities;Health Sciences;Health Services;Health system;Healthcare Systems;Home;hospital organization;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;laboratory development;life span;Mentors;Modeling;multidisciplinary;National Institute of General Medical Sciences;New England;Nonprofit Organizations;organizational structure;Outcome;patient oriented;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;prevent;Productivity;Program Development;Program Evaluation;programs;Protocols documentation;Public Health;Publications;Research;Research Design;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Resources;Rhode Island;Services;success;synergism;Teacher Professional Development;Testing;Training;Translating;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Universities;virtual;Vulnerable Populations

PROJECT_TITLE: Advance Clinical and Translational Research (Advance-CTR): Pragmatic Acceleration of Community-Engaged Education for Data-Driven Health Sciences (PACE-DHS)


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Schizophrenia

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

PHR: PROJECT NARRATIVE This project will investigate how the brain uses rules to guide our behavior. Rules define how we should act in a given situation and so disrupting one’s ability to learn and follow rules carries significant social and economic costs for many neuropsychiatric and neurodegenerative diseases, including schizophrenia. Our work will provide insight into the neural mechanisms of rule-based behavior, providing the foundation for a better understanding of these diseases.

PI_NAMEs: BUSCHMAN, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Neural Mechanisms of Rule-Based Behavior


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Food Allergies;Genetics;Human Genome;Prevention

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Allergic disorders including food allergy, hay fever, eczema, and asthma, affect approximately 25% of people in industrialized countries and can cause life threatening reactions. Genetic differences among individuals account for about half of the risk of allergy; identifying the underlaying genes and biological pathways could suggest new strategies to treat and prevent allergy. Whereas the genetics of allergy has largely been studied in cell lines, we will pioneer an approach to study allergy at the single cell level in heterogenous human pathology specimens encompassing diverse clinical subtypes.

PI_NAMEs: KASOWSKI, MAYA  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Affect;Allergens;Allergic;Allergy to peanuts;Asthma;Autopsy;biobank;Biological;Biological Assay;Biology;Blood;Blood specimen;Catalogs;Caucasians;causal variant;Cell Line;cell type;Cells;Child;clinical subtypes;Complex;Developed Countries;Disease;Eczema;Environmental Risk Factor;Etiology;follow-up;Food Hypersensitivity;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Risk;genetic variant;Genome;genome wide association study;genomic locus;Genotype-Tissue Expression Project;Hay fever;Heritability;Human;human disease;Human Pathology;Human Resources;human tissue;Hypersensitivity;Incidence;Individual;innovation;Life;Link;Maps;Mediator;Methods;Molecular;multiple omics;Nature;Pathway interactions;Patients;Persons;Play;Population;prevent;Reaction;Risk;risk variant;Role;Schools;Specimen;Stimulus;Tissues;Untranslated RNA;Work;World Health

PROJECT_TITLE: A single cell pooling framework for deciphering the regulatory wiring of allergy in pathophysiologic contexts


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Much has been learned about neural circuitry and function; however, we still lack a fundamental understanding of how neural activity drives complex behavior and how naturalistic environments influence long-term neural activity. To address this, we will design, implement, and share an innovative neuro-behavioral recording and real-time processing platform that integrates complex behavioral measures with months-long, uninterrupted, wireless neural imaging across a colony of animals living uninterrupted in large, naturalistic environments. Collected data will span learning, recall, sleep, social behavior, and aging and will be shared openly and in real-time through a novel collaborative data sharing framework.

PI_NAMEs: AHARONI, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Address;Aging;Animals;Basic Science;Behavior;behavior measurement;Behavioral;Brain;Cells;Cognitive;Communities;Complex;computer framework;Computer software;computerized tools;Data;Data Set;data sharing;Databases;design;Devices;Disease;Educational workshop;Environment;environmental enrichment for laboratory animals;experimental study;Generations;Hippocampus;imaging capabilities;innovation;insight;Investigation;Learning;Maps;Microscope;Nervous System Disorder;neural;neural circuit;neurobehavioral;neuroimaging;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;novel;novel strategies;open source;Process;Resolution;Sleep;Social Behavior;Techniques;Technology;Time;tool;Transgenic Mice;web site;Weight;wireless

PROJECT_TITLE: Developing long-term neuro-behavioral recording and real-time processing platforms for naturally behaving animals


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative: Shifting Suicide Prevention Paradigms: Looking Beyond Clinical Settings The goal of this research is to shift the paradigm of suicide prevention research by prioritizing social determinants through broad, but strategic, partnerships with industries outside of mental health care. By transforming psychological autopsy methodology into social autopsy and surveying and interviewing individuals who work in industries dealing with the depths of life disruption (i.e., family law, mortgage foreclosure, and unemployment processing), this project challenges the status quo of suicide prevention research that is anchored in clinical environments. This unconventional path through non-mental health industries is the chance to bring new perspectives and novel ideas for better, richer, novel data to inform suicide prevention strategies.

PI_NAMEs: BLOSNICH, JOHN RUDOLPH (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Autopsy;Cessation of life;Client;Clinical;Coupled;COVID-19 pandemic;Data;Detection;Distress;Divorce;Employee;Environment;Epidemic;experience;Family;Feeling suicidal;Financial Hardship;Foreclosure;Funding Mechanisms;Goals;Health;Health Sciences;Healthcare;housing instability;Individual;Industry;Intervention;Interview;Intuition;invention;Job loss;Knowledge;Laws;Legal;Life;Medical Care Costs;Mental Health;Mental Health Services;Methodology;Nature;novel;novel strategies;Occupational;Persons;Populations at Risk;Prevention;Prevention Research;Prevention strategy;preventive intervention;Production;Productivity;psychologic;Psychopathology;Public Health;public health research;Qualifying;Research;Research Personnel;Risk;Services;social;social determinants;stem;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Testing;Thinking;Training;Unemployment;Work


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Crucial to the wiring of neural circuits is the expression of sufficient Protocadherin (Pcdh) protein isoform diversity such that essentially every neuron in the brain is uniquely barcoded at its surface and therefore capable to self-recognize and self-avoid. This proposal aims to develop novel genomic, genetic and biochemical approaches to test a new model of Pcdh RNA splicing mechanism. The findings from this work will provide general principles of gene expression regulation of Pcdh genes and more broadly in vivo.

PI_NAMEs: CANZIO, DANIELE  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: 3-Dimensional;Architecture;autism spectrum disorder;Bar Codes;Biochemical;Brain;Brain Diseases;Cells;Complex;design;DNA;Ensure;essays;Exons;Gene Cluster;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;Genomics;in vivo;Individual;Mammals;Mediating;Messenger RNA;Modeling;mRNA Precursor;Nervous System Disorder;neural circuit;Neurons;Neurosciences;novel;Process;Property;Protein Isoforms;Reaction;RNA;RNA Processing;RNA Splicing;Role;Schizophrenia;Surface;technological innovation;Testing;tool;Trans-Splicing;Work

PROJECT_TITLE: How do neurons recognize self from non-self?


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Temporal processing is central to cognition and behavior, and it has been hypothesized that memory deficits in Alzheimer’s disease and Schizophrenia result from disrupted temporal coordination and temporal processing within the brain. However, the neural mechanisms that underlie the brain’s ability to encode time remain largely unknown. This proposal will address the question of how the brain perceives and stores memories of temporal duration on the scales of seconds and minutes by leveraging cutting-edge optical imaging techniques in order to monitor and manipulate neural activity as mice engage in virtual-reality based timing behaviors.

PI_NAMEs: HEYS, JAMES GERARD (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Alzheimer's Disease;Anterior;awake;Axon;Behavior;Behavioral;Behavioral Paradigm;Brain;Brain region;cingulate cortex;circadian;Code;Cognition;cognitive neuroscience;Complex;Dendrites;entorhinal cortex;Event;experience;Functional Imaging;Future;Hour;Image;Imaging Techniques;Individual;Laboratories;Learning;Medial;Memory;Memory impairment;Methods;millisecond;Modeling;Monitor;Mus;Nervous System Physiology;neural;neural circuit;neuromechanism;Neurons;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;Population;Positioning Attribute;Process;Publishing;Resolution;Schizophrenia;Signal Transduction;Synapses;System;Testing;Time;time interval;virtual reality;Work

PROJECT_TITLE: Uncovering the neural circuit and synaptic mechanisms underlying interval timing


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: We work at the intersection of neuroscience and epigenetics which explores how our experiences and environment changes transcription of our genes. We seek to uncover the transcriptional signature encoding a memory within a neuron and how this is influenced by epigenetic mechanisms. Through this work, we hope to understand how the world around us influences gene regulation in the brain to allow us to learn, adapt, and become the people we are today.

PI_NAMEs: KORB, ERICA MEGAN (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affect;Behavior;Biochemical;Biology;Brain;Cells;Chromatin;Complex;Cues;Disease;DNA;Environment;Epigenetic Process;epigenome;experience;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Histones;in vivo;Label;Lead;Learning;Maintenance;Maps;Memory;Mental disorders;Methods;Molecular;mouse model;Nervous System;Neurologic;Neuronal Dysfunction;Neurons;Neurosciences;novel;Persons;Post-Traumatic Stress Disorders;programs;Proteins;recruit;Regulation;response;Reversal Learning;Signal Transduction;single nucleus RNA-sequencing;Structure;Techniques;tool;Transcription Process;Transcriptional Regulation;Work

PROJECT_TITLE: The epigenetic encoding of learning and memory


NIH_SPENDING_CATS: Data Science;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative A large number of gene mutations that are associated with disease risk have been identified for diverse diseases. Hypotheses about how these mutations confer disease risk and their effects on cells and tissues are needed in order to prioritize therapeutic targets for intervention. This study proposes computational frameworks for identifying gene mutations that affect cellular behaviors of individual human cells, therefore enabling prioritization of therapeutic targets.

PI_NAMEs: QUON, GERALD  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Behavior;Biological Assay;cell behavior;cell type;Cells;computer framework;data integration;deep learning;Development;Disease;Disease Progression;disorder risk;Electrophysiology (science);Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genetic;genetic association;Genetic Risk;Genetic Variation;Genotype;Goals;Human;Individual;Intervention;Link;Manuals;Measurement;Measures;Mediating;Mediation;Mental disorders;Modeling;Molecular;Morphology;multimodal data;multimodal modeling;Mutation;Neurodevelopmental Disorder;Neurons;Organ;Pattern;Phenotype;response;Risk;skills;therapeutic target;Tissues

PROJECT_TITLE: Linking genetics to cellular behavior and disease via multimodal data integration


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The major challenge in understanding how the brain functions is the lack of knowledge and tools in tackling neuron-glial interactions. The project aims to develop a method to profile critical molecules that mediate neuron- glial communications in vivo with the spatiotemporal precision. We will apply this method in oligodendrocytes and axons to understand the molecular mechanisms governing axon ensheathment and myelination selectivity.

PI_NAMEs: SUN, LU  (contact)

PROJECT_TERMS: Axon;Biology;Brain;brain cell;Cell Communication;Cell surface;Cells;Central Nervous System;Code;Communication;CRISPR screen;design;Development;Dissection;Genetic;genome-wide;Human;Immune;in vivo;Knowledge;Label;Malignant Neoplasms;Mediating;Methods;Molecular;Mouse Strains;Myelin;myelination;Nervous System Physiology;Neuroglia;Neuroimmune;Neurons;novel;Oligodendroglia;Proteomics;Reagent;single-cell RNA sequencing;spatiotemporal;Surface;System;tool;Transgenic Mice;Visualization;Work

PROJECT_TITLE: Molecular and genetic decoding of neuron-glial interactions


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Patient Safety;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: PROJECT NARRATIVE Airway protective disorders are a prevalent and progressive consequence of Parkinson’s Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD, yet many patients with PD do not access specialized services to address these critical deficits, especially individuals from historically marginalized groups. As an administrative supplement to our parent award R01 NS126319-01, we will utilize an embedded mixed methods design, in which we will use qualitative data to (1) understand how participants experience EMST and CST treatment both in-person and via telehealth and (2) explain quantitative treatment outcomes. In alignment with NIH, NINDS, and HERN priorities, the goal of this work is to improve person- centered, accessible, and equitable care to improve the health and well-being of persons with Parkinson’s disease – an area of public health need.

PI_NAMEs: TROCHE, MICHELLE S (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Administrative Supplement;Affect;Area;Aspiration Pneumonia;Black Populations;Caring;Cause of Death;Cities;Clinical Research;Coughing;Data;Deglutition;Deglutition Disorders;deprivation;design;Disadvantaged;Disease;Disparity;Disparity population;disparity reduction;Ensure;Equity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Functional disorder;Future;Geography;Goals;Health;health care disparity;health inequalities;Health Services Accessibility;Healthcare;Hispanic Populations;implementation facilitation;Improve Access;improved;indexing;Individual;Intervention;Interview;Invaded;Laboratories;Life;Literature;Maintenance;marginalized population;Measures;medical specialties;Methodology;Methods;Minority Groups;Modeling;Modification;muscle strength;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Outcome;parent project;Parkinson Disease;Participant;Patients;Peak Expiratory Flow Rate;person centered;Personal Satisfaction;Persons;Population;pressure;Public Health;Quality of life;racial minority;racial minority population;racial population;rehabilitation service;Rehabilitation therapy;rural area;satisfaction;Service delivery model;Services;skills training;strength training;Structure;targeted treatment;telehealth;treatment adherence;treatment comparison;Treatment outcome;Underrepresented Populations;United States;United States National Institutes of Health;uptake;urban dwelling;Work

PROJECT_TITLE: Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-Person and Telehealth Service Delivery Models

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Prevention;Radiation Oncology;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PI_NAMEs: CHEN, CHAO  (contact);PRASANNA, PRATEEK

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;angiogenesis;anti-cancer research;Architecture;Biology;Black Box;Breast;Breast Cancer Patient;breast imaging;cancer recurrence;cancer risk;Clinical;clinical predictors;Collaborations;Communities;Complex;computer scientist;Data;Data Analyses;Descriptor;Development;Discipline;Early Diagnosis;Early treatment;effectiveness evaluation;Event;Glass;Grain;high risk;Image;imaging informatics;improved;insight;Instruction;Intuition;Learning;learning ability;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Methodology;Methods;Modeling;Modification;multidisciplinary;Neurosciences;novel;Outcome;predictive modeling;preservation;Prognosis;Quality of life;radiation response;Radiation therapy;Radiology Specialty;radiomics;Research;Research Personnel;response;Scanning;screening;Structure;Techniques;The Cancer Imaging Archive;Three-Dimensional Image;Three-Dimensional Imaging;Tissues;Training;Treatment Effectiveness;treatment response;Uncertainty;Visualization;Women's Health;Work

PROJECT_TITLE: SCH: Topological Methods for Breast Tissue Quantification


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The tectorial membrane plays an important role in the inner ear by stimulating hair cells in order to transduce sound. We have recently discovered a mutation in TECTB, which encodes an important organizing protein in the tectorial membrane which causes hearing loss in humans. We propose to investigate the effects of this mutation on the tectorial membrane through a mouse model to better understand its pathology and potential treatments, as well as supplement critical data towards establishing TECTB as a human deafness gene.

PI_NAMEs: HALE, EVAN BROWN (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Actins;Alleles;Animal Model;Animals;Auditory;Auditory Brainstem Responses;Auditory Threshold;autosome;cell type;Cells;Cochlea;Cochlear nucleus;cohort;Coupled;Data;Data Collection;deafness;design;Development;disulfide bond;Drops;Environment;Evaluation;Exhibits;Exposure to;Extracellular Matrix;Family;Fiber;Functional disorder;Future;Genes;Goals;Hair;Hair Cells;Hearing;hearing impairment;Hearing Tests;Heterozygote;Histologic;Homology Modeling;Human;insight;Investigation;Knock-in Mouse;Labyrinth;Measurement;mechanotransduction;Modeling;Motility;mouse model;Mus;mutant;Mutation;Nicaraguan;Noise;noise exposure;noise trauma;Organ of Corti;otoacoustic emission;Otolithic Membrane;Outer Hair Cells;Pathology;Patients;Phenotype;Physiological;Play;Point Mutation;predictive modeling;Predisposition;Process;progressive hearing loss;protein structure;Proteins;resilience;Resolution;Role;Sensory;Sensory Hair;Signal Transduction;sound;Structure;tectorial membrane;Testing;Therapeutic;transmission process;Variant;Wild Type Mouse;X-Ray Crystallography

PROJECT_TITLE: Effects of the TECTB-C225Y Variant in the Inner Ear

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (15)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE We utilize an innovative multimodal neuroimaging approach to better understand how sleep disturbances and brain networks that regulate emotion may underlie the clinically distressing and economically relevant problem of neuropsychiatric symptoms in those with mild cognitive impairment and Alzheimer’s dementia. The findings will provide a foundation for developing sleep based, mechanism-focused preventative strategies and treatments for neuropsychiatric symptoms in Alzheimer’s dementia that are personalized for the individual.

PI_NAMEs: GOLDSTEIN-PIEKARSKI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Agitation;Alzheimer's Disease;Alzheimer's disease patient;Amygdaloid structure;Anxiety;Area;arm;Behavior Therapy;Behavioral;Behavioral Symptoms;Belief;Biological Assay;Brain;brain dysfunction;Clinical;Cognitive Therapy;density;Development;Distress;Education;Electroencephalography;emotion regulation;emotional distress;emotional experience;Emotions;Equipment and supply inventories;experience;Foundations;Generations;high risk;Impairment;improved;improvement on sleep;Individual;innovation;Intervention;Maintenance;Mediating;Mental Depression;Methodology;Methods;mild cognitive impairment;Modeling;multimodal neuroimaging;neuropsychiatric symptom;neuropsychiatry;Participant;Patient Self-Report;Patients;Physiological;Prefrontal Cortex;Prevention strategy;Preventive treatment;Randomized;reduce symptoms;Sampling;Sleep;Sleep disturbances;sleep health;sleep pattern;Sleeplessness;Stimulus;symptomatic improvement;targeted treatment;Testing

PROJECT_TITLE: Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE (from Parent Grant) Calcium signaling helps maintain normal cellular functions, but pathogens, including intestinal viruses like rotavirus, reprogram normal cellular calcium pathways to commandeer cellular machinery for their replication, which results in potentially life-threatening diseases like diarrhea. We recently discovered that rotavirus infection triggers long-distance signaling that also increases calcium in surrounding uninfected cells in the gut. This proposal investigates how this long-distance calcium signal is involved in host responses to rotavirus-induced damage but also exploited by rotavirus to increase its replication and spread.

PI_NAMEs: HYSER, JOSEPH M. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acute;Anti-viral Therapy;arms race;Binding;Biological Response Modifiers;Calcium;Calcium Signaling;Cell Physiology;Cells;cellular targeting;Cessation of life;Child;Chlorides;Data;Diarrhea;Disease;Endoplasmic Reticulum;Enteral;enteric pathogen;Epithelium;Fluids and Secretions;Gastroenteritis;Immune response;insight;Intestines;Life;Link;MAP Kinase Gene;Mediating;Nonstructural Protein;novel;paracrine;parent grant;pathogen;Pathogenesis;Pathway interactions;programs;purinoceptor P2Y1;Recombinants;response;Rotavirus;Rotavirus Infections;Serotonin;Signal Pathway;Signal Transduction;stem cell biomarkers;Testing;Training;Viral;Virus;Virus Replication

PROJECT_TITLE: Training Supplement in Enteric Virus Exploitation of Calcium Signaling

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PI_NAMEs: PARDE, NATALIE  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Address;Advocate;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Brain;Classification;Clinical;Cognitive;cognitive testing;cohort;commune;cost;cost effective;Data;Dementia;design;Detection;Disease;Early Diagnosis;Early identification;Economics;Elements;Engineering;Ensure;Equity;experience;explainable artificial intelligence;feature extraction;forging;frontal lobe;Genetic Transcription;Goals;Health;health assessment;health care disparity;health care settings;Healthcare;Healthcare Systems;Human;Impaired cognition;Impairment;improved;Individual;innovation;insight;Instruction;Knowledge;Language;large language model;Learning;lexical;Linguistics;medial temporal lobe;Methods;mild cognitive impairment;Modeling;Multilingualism;Natural Language Processing;novel;Outcome;Output;Pathologic;Pathway interactions;Pattern;Performance;Phase;pre-clinical;prodromal Alzheimer's disease;prompt engineering;Quality of life;Recommendation;Research;Resources;responsible artificial intelligence;Sampling;screening;Screening procedure;Semantics;Severity of illness;Societies;Speech;stem;Structure;Techniques;Testing;Time;Work

PROJECT_TITLE: SCH: Fair and Interpretable Prediction of Alzheimer's Disease and MCI using LLMs


ORG_DEPT: NEUROSURGERY

PHR: NARRATIVE – Overall The UCLA Brain Cancer SPORE will support research into new and innovative strategies to diagnose and treat brain cancer, particularly focusing on innovative ways to overcome the problem of treatment-induced resistance to current therapies (i.e., immunotherapy, chemo/drug therapy, and radiation therapy resistance). Despite many different treatment approaches, the five-year survival rate for glioblastoma (WHO grade IV) patients remains dismal, and there are still no definitive cures for this disease. Thus, the proposed research is of relevance to public health, as there is clearly an unmet need for patients with this type of cancer and continued investigations into novel therapeutic approaches for brain cancer are desperately needed.

PI_NAMEs: LIAU, LINDA M (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Active Immunotherapy;Acute;Address;anti-cancer research;Apoptosis;Apoptotic;Area;Awareness;Basic Science;Biochemistry;Bioinformatics;Biological Markers;Biomedical Engineering;Biometry;Brain;Brain Neoplasms;Cancer Patient;cancer type;career;career development;Cell Death;Cell Nucleus;Cells;Clinical;clinical care;Clinical Research;Combination immunotherapy;Combined Modality Therapy;Companions;CSF1R gene;data management;design;Development;Diagnosis;Discipline;Disease;Endocrinology;Equilibrium;Fostering;Funding;Future;Glioblastoma;Glioma;Goals;Grant;Head and Neck Surgery;Human;human capital;Human Genetics;Image;Immune Evasion;immune resistance;Immunology;Immunotherapeutic agent;Immunotherapy;improved;Industry;Infrastructure;innovation;Institution;International;Investigation;Laboratories;Leadership;Magnetic Resonance Imaging;Malignant neoplasm of brain;Medicine;Metabolism;Microbiology;Molecular Genetics;multidisciplinary;neoplastic cell;neuroimaging;Neurosciences;new technology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Paper;Pathology;Patients;Pediatrics;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Physicians;Positron-Emission Tomography;pre-clinical;Prognosis;programmed cell death protein 1;programs;Psychiatry;Public Health;Publishing;Radiation;Radiation Oncology;Radiation therapy;Radiology Specialty;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Scientist;Specimen;stem cells;Survival Rate;Talents;Technology;Testing;therapy development;therapy resistant;translational approach;Translational Research;translational research program;tumor diagnosis;tumor microenvironment;United States National Institutes of Health;Vaccination;Work

PROJECT_TITLE: Investigating Mechanisms of Adaptive Immune Resistance to Combination Immunotherapy within the Glioblastoma Microenvironment


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Suicide

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: RELEVANCE (See instructions): This study will lead to the creation and evaluation of an innovative approach for delivering clinical common factors and micro-skills experiential training to lay and paraprofessional mental healthcare providers. Results from this study are likely to generalize to and inform the evolution of many online mental health services and offline mental health support settings, including, for example, training for volunteers staffing suicide hotlines, social workers, and nurses.

PI_NAMEs: SWARTZ, HOLLY A;YANG, DIYI ;ZHU, HAIYI  (contact)

PROJECT_TERMS: Address;Anxiety;Attention deficit hyperactivity disorder;Caring;Client;Clinical;Cognitive;Consensus;cost;Cost Savings;Counseling;design;disparity reduction;Educational process of instructing;Empathy;Environment;Evaluation;evidence base;Evolution;Feedback;Feeling;formative assessment;generative artificial intelligence;Goals;Hallucinations;health care availability;Health Personnel;Health Professional;health training;Healthcare;Human;human-in-the-loop;improved;Individual;innovation;Instruction;interest;Intervention;iterative design;Knowledge;large language model;Licensing;Low income;Measures;Mental Depression;Mental Health;Mental Health Services;mental training;Methods;Modeling;Monitor;Nurses;Occupations;Outcome;Participant;participant retention;peer;people of color;Play;Professional counselor;Protocols documentation;Provider;psychologic;Psychotherapy;recruit;Research;Research Personnel;Research Project Grants;Resistance;Role;satisfaction;Services;Site;skills;Social Workers;Standardization;Stress;suicidal;suicide hotline;System;Technology;Text;Training;Trust;usability;virtual patient;volunteer;Vulnerable Populations;Youth

PROJECT_TITLE: SCH: Training Mental Health Supporters with Virtual Patients and Automated Feedback


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The proposed research will develop a principled, scalable, and reproducible approach for rigorous and timely evaluation of the safety and effectiveness of generic drug-device combinations compared to brand-name reference products using large longitudinal healthcare datasets. We will demonstrate this approach for generating multi-phase actionable real-world evidence in 2-3 use cases, including description of utilization patterns, evaluation of comparative effects, and systematic screening for unsuspected safety issues. This project will provide the Food and Drug Administration with a reusable framework and set of tools for generating real-world evidence to evaluate complex generic drugs in the post-marketing setting.

PI_NAMEs: FELDMAN, WILLIAM BRAND (contact);WANG, SHIRLEY

PROGRAM_OFFICER_NAME: CLERMAN, ANDREW

PROJECT_TITLE: The Safety of Switching Between Complex Branded and Generic Drugs: Developing a Semi-Automated Sequential Surveillance System Using Tree-Based Scan Statistics

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (04)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Epidemiological evidence shows that women represent a particularly vulnerable population in Substance Use Disorder, and preclinical studies have demonstrated a significant sex difference in reward processing and motivated behavior in female subjects. Acetylcholine released from cholinergic (ChAT) interneurons in the nucleus accumbens (NAc) acting through pentameric nicotinic acetylcholine receptors (nAChRs), is a potent regulator of dopamine release underlying reward processing in the NAc. In this proposal I will determine both the subunits of nAChRs modulating sex differences in reward processing and behavior as well as the circuit and cell-type specific regulation of dopamine release within the local NAc circuit by ChAT interneuron modulation of nAChR activity.

PI_NAMEs: BRADY, LILLIAN J. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acetylcholine;Advisory Committees;Behavior;Behavioral;behavioral pharmacology;behavioral response;Biological Factors;Brain;Brain Diseases;cell type;Cells;cholinergic;Chronic;Consumption;Cues;Data;Development;Doctor of Philosophy;Dopamine;drug of abuse;efficacious treatment;Electrophysiology (science);Epidemiology;Exhibits;experience;Female;Fiber;Functional disorder;gamma-Aminobutyric Acid;Goals;high risk;Human;in vivo;interest;Interneurons;Intervention;Laboratories;Learning;Link;male;Mediating;Mediation;Mediator;meetings;men;mesolimbic system;motivated behavior;Motivation;Mus;Nervous System Disorder;neural circuit;neuromechanism;neuroregulation;neurotransmission;Nicotinic Receptors;Nucleus Accumbens;Optics;optogenetics;Pattern;Periodicity;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Photometry;Physiology;Play;Population;Postdoctoral Fellow;postsynaptic;preclinical study;Predisposition;presynaptic;Process;professor;Psychological reinforcement;Publications;receptor;Recurrence;Regulation;Research;Research Personnel;Research Training;response;reward circuitry;reward processing;Rewards;Risk;Rodent Model;Role;Running;Scanning;Self Administration;sensor;sex;Sex Differences;Shapes;Signal Transduction;Site;skills;Slice;Substance Use Disorder;substance use treatment;Sucrose;Synaptic Transmission;Syndrome;Techniques;Testing;Training;Ventral Tegmental Area;Vulnerable Populations;Woman;women subjects;Work

PROJECT_TITLE: Sex differences in cholinergic regulation of nicotinic acetylcholine receptor modulation of local nucleus accumbens circuitry underlying motivation


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: AIDS-associated cryptococcosis continues to ravage communities impacted by high HIV transmission rates, causing 15% of AIDS-associated mortality. Our work investigates the molecular mechanisms by which C. neoformans, among the millions of species of fungi, is able to adapt to the host environment, coping with the stresses it encounters. We have identified pathways required for agility in stress adaptation, and will investigate how they promote stress adaptation, cooperate with other pathways, and how conserved these responses are across diverse clinical isolates from people with AIDS-associated cryptococcosis as well as environmental isolates from the same region.

PI_NAMEs: PANEPINTO, JOHN C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Area;biological adaptation to stress;Clinical;Collection;Communities;Cryptococcosis;Cryptococcus neoformans;Cytoplasm;Data;Defect;Environment;Excision;fungus;Future;Genome;HIV;Investigation;lonely individuals;Messenger RNA;Mitochondria;Molecular;mortality;mRNA Decay;Nonsense-Mediated Decay;Outcome;Output;Oxidative Stress;p38 Mitogen Activated Protein Kinase;pathogen;pathogenic fungus;Pathway interactions;Persons;Phenotype;Phosphotransferases;posttranscriptional;Process;Quality Control;Reactive Oxygen Species;Regulation;Regulatory Pathway;Regulon;Resources;response;Ribosomes;Role;Stress;Stress and Coping;Temperature;Therapeutic Intervention;transcription factor;Translating;Translation Initiation;Translational Regulation;Translations;translatome;transmission process;Virulence;Work;Yeast Model System

PROJECT_TITLE: Supplement to: Stress Responsive Reprogramming of Translating mRNA Pools in C. neoformans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Diversity Supplement on Funded Grant RF1 AG084134 “Biomarkers to Track Effective Interventions That Delay Dementia Onset In Participants of the "Risk Reduction for Alzheimer's Disease (rrAD)" Trial” Project Narrative: This proposed supplement aims to identify sex differences in immune dysregulation and inflammatory cytokines in subjects with cardiovascular risk factors (i.e hypertension and dyslipidemia) and at risk for Alzheimer’s disease and related dementias (ADRD) and determine if an effective lifestyle intervention will delay the development of dementia. Additionally, this project will help refine the fluid biomarkers and distinguish between males and females with high risk for ADRD, consequently improving diagnosis and drug development for Alzheimer’s disease and related dementias.

PI_NAMEs: GERMAN, DWIGHT C.;STOWE, ANN MARIE (contact);ZHANG, RONG ;ZHU, DAVID C

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adult;Aerobic Exercise;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anti-Inflammatory Agents;Biological Markers;Biometry;Blood Pressure;Brain Pathology;Cardiovascular Diseases;cardiovascular risk factor;career;career development;Cells;Clinical Trials;Cognitive;cognitive function;cohort;cytokine;Data Analyses;Data Collection;Dementia;dementia risk;Development;Development Plans;Diagnosis;Doctor of Medicine;Doctor of Philosophy;drug development;Dyslipidemias;effective intervention;Ensure;Etiology;Experimental Designs;Female;FGF2 gene;Fibrinogen;Foundations;Funding;Future;Goals;Grant;Health;high risk;Human;Hypertension;Immune;Immune system;Immunophenotyping;improved;Incidence;Inflammation;Inflammatory;Injury;Intervention;Learning;lifestyle intervention;Lipids;Liquid substance;male;Manuscripts;Mediating;Mentors;Mentorship;older adult;Outcome;Participant;Pathogenesis;Peripheral;Peripheral Blood Mononuclear Cell;pharmacologic;Plasma;Risk Reduction;Role;sex;Sex Differences;specific biomarkers;Subgroup;systemic inflammatory response;tau Proteins;Testing;Training;vascular cognitive impairment and dementia;Vascular Endothelial Growth Factor D;vascular risk factor;Women's prevalence;Writing

PROJECT_TITLE: Diversity Supplement for Jenny Lutshumba


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE All cells must regulate genes in order to divide, differentiate and die. This proposal employs cutting-edge genomic techniques to better understand how single cells use MYC-network transcription factors to make these decisions in stem cell pluripotency. The results will inform our basic understanding of how cells divide and differentiate in mammalian development and ultimately help understand how these proteins can deregulate cellular growth during cancer.

PI_NAMEs: RAMANI, VIJAY  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Atlases;cell growth;Cells;chemical genetics;Chemicals;Chromatin;computerized tools;Decision Making;Development;Dissection;dosage;Dose;embryonic stem cell;epigenome;experimental study;Genes;Genetic Transcription;Genome;Genomics;Health;Helix-Turn-Helix Motifs;Homeostasis;in vivo;insight;Leucine Zippers;Link;Malignant Neoplasms;Maps;Metabolism;Methods;novel;Output;Play;pluripotency;Proliferating;protein degradation;Proteins;Publishing;Role;screening;Seminal;single-cell RNA sequencing;Stem cell pluripotency;Techniques;transcription factor;transcriptomics

PROJECT_TITLE: SINGLE-CELL CHEMICAL TRANSCRIPTOMIC DISSECTION OF AN ESSENTIAL TRANSCRIPTION FACTOR NETWORK


ADMINISTERING_IC: ES

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Social Determinants of Health

ORG_CITY: BETHLEHEM

ORG_NAME: LEHIGH UNIVERSITY

PHR: RELEVANCE (See instructions): Pennsylvania Asthma-COPD Syndromic Surveillance (PASS) meets the urgent public health needs of our citizens by building a nimble data analytic system capable of parsing out the emergent (i.e., air pollution-attributable) from the legacy (i.e., systemic built environment, access, and socioeconomic disparity) risks of lower respiratory infection, asthma, and COPD, referred to herein as chronic respiratory syndrome (CRS). We will clarify how Pennsylvania's recurrent air pollution episodes and erratic weather patterns contribute to 'outbreaks' of lower respiratory infections in children and asthma and COPD outbreaks in all age groups within specific geographic locations. Our system will meet the needs of Pennsylvania citizens and healthcare managers by detecting, warning, and anticipating air pollution-associated outbreaks of CRS exacerbation cases in emergency room visits and hospitalization.

PI_NAMEs: CHOI, HYUNOK  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Accounting;Acute;age group;Air;Air Pollutants;Air Pollution;ambient air pollution;Asthma;attributable risk;built environment;Case Manager;Censuses;Child;Childhood;Chronic;Chronic Obstructive Pulmonary Disease;Cities;Clinical;comorbidity;Country;Data;Data Analytics;data streams;Development;Disadvantaged;Disease Outbreaks;Disparity;Emergency department visit;empowerment;Environment;environmental justice;Environmental Pollution;Environmental Risk Factor;Environmental Wind;Event;Excess Mortality;extreme weather;fine particles;Fossil Fuels;Geographic Locations;Goals;Health;health care settings;Healthcare;high risk;Hispanic;Hospitalization;Humidity;Infrastructure;innovation;Instruction;Low income;Lower Respiratory Tract Infection;Maps;Meteorological Factors;metropolitan;Nature;Neighborhoods;Nitrogen Dioxide;novel;Obesity;outbreak prediction;Overweight;Ozone;Particulate Matter;Patients;Pennsylvania;Persons;pollutant;Population;Poverty;Predisposition;Provider;Public Health;Recurrence;Resources;respiratory;respiratory health;Risk;Risk Factors;screening;second-hand cigarette smoke;Shapes;social;social adversity;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;Speed;stressor;Syndrome;syndromic surveillance;System;Temperature;Testing;Time;trend;Visualization;Vulnerable Populations;weather patterns;years of life lost

PROJECT_TITLE: SCH: Pennsylvania Asthma-COPD Syndromic Surveillance (PASS)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PI_NAMEs: WANG, JIAN-XUN  (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Artificial Intelligence enhanced;Bayesian learning;Blood;Blood flow;Cardiovascular Diseases;cardiovascular health;Cardiovascular Models;Cardiovascular Physiology;Cardiovascular system;Caring;Cause of Death;Clinical;clinical imaging;Collaborations;combat;Complex;Computational Geometry;computational platform;Computer Models;cost;Data;data reduction;deep learning;design;Device Designs;Diagnosis;diagnostic tool;disability;Functional disorder;Geometry;Goals;Graph;Health;Health Professional;Healthcare;Heart;Heart Diseases;Hematological Disease;hemodynamics;human error;Image;imaging Segmentation;improved;innovation;insight;Instruction;Knowledge;Laws;Life;Liquid substance;Lung;Lung Diseases;Machine Learning;Manuals;Maps;Medical Imaging;Methodology;Mission;Modeling;models and simulation;Nature;neural;neural network;novel;novel strategies;Operative Surgical Procedures;Patients;Pattern;Physics;predictive modeling;pressure;Prevention;Process;Prognosis;programs;Public Health;reconstruction;Research;response;risk stratification;Selection for Treatments;shear stress;simulation;spatiotemporal;stem;Stress;Structure;Techniques;Technology;Time;treatment strategy;trustworthiness;Uncertainty;United States National Institutes of Health;Visual;Visualization;Visualization software

PROJECT_TITLE: SCH: Efficient Image-based Hemodynamic Modeling via Physics-integrated Bayesian Deep Learning


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Not needed for this submission.

PI_NAMEs: ESCOBAR HOYOS, LUISA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Malignant neoplasm of pancreas;mutant;RNA Splicing

PROJECT_TITLE: Understanding and targeting mutant splicing factors in pancreatic cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]