ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Emotional arousal is fundamental to how we experience emotions, is highly susceptible to stress, and is a core dimension to affective-related psychopathologies (anxiety, depression, irritability), making it a key bio-behavioral target for investigations of transdiagnostic mechanisms underlying the development of these mental health problems. The current proposal aims to develop a straight-forward, developmentally-appropriate tool to measure phasic changes in arousal to provide a common metric that can be used across diverse ages, designs, and settings. The work in the proposal will measure an arousal task’s psychometric properties during pupillometry, autonomic responses (HR, SCR), and behavioral ratings, assess how these measures track affect-related psychopathology (anxiety, depression, irritability) during development, and identify associations between arousal-induced brain function and affect-related psychopathological symptoms during development.

PI_NAMEs: MILHAM, MICHAEL PETER;TOTTENHAM, NIM  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 20 year old;Address;Adult;Affect;Affective;Age;age difference;Anxiety;Arousal;Auditory;auditory stimulus;Behavior;Behavioral;biobehavior;Brain;cohort;Complex;Data;design;Development;Diagnostic;Dimensions;Disease;Ecological momentary assessment;Emotional;emotional functioning;Emotions;Etiology;experience;Family history of;Foundations;Galvanic Skin Response;Goals;habituation;Hand;Heart Rate;high risk;impression;Individual;Individual Differences;innovation;insight;Investigation;Learning;Life;Link;Measures;Mental Depression;mental development;Mental disorders;Mental Health;Nature;negative affect;neural correlate;neurobehavioral;Neurobiology;Nursery Schools;Pathologic;Pattern;Phase;phase change;Physiology;Play;predicting response;Predisposition;Property;Psychometrics;Psychopathology;psychosocial;Readiness;response;Risk;Role;Sampling;School-Age Population;Signal Transduction;Standardization;Stimulus;Stress;symptomatology;Symptoms;System;Testing;tool;Validity and Reliability;Work;young adult

PROJECT_TITLE: Emotional Arousal and its Neurobehavioral Associations during Development

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative The annual Translational Glycomics Symposium, hosted by the Versiti Blood Research Institute, is a vibrant platform for trainees and young investigators to present their groundbreaking research, network with peers and seasoned experts, and foster a diverse and inclusive scientific community. This symposium brings together leading researchers from around the world, fosters collaboration, and accelerates the translation of glycoscience discoveries into clinical practice. By showcasing the transformative potential of glycoscience research, the symposium aims to propel this field to the forefront of modern medicine, ultimately paving the way for novel treatments and empowering doctors to better serve their patients.

PI_NAMEs: HOFFMEISTER, KARIN MARIA (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TITLE: The Translational Glycomics Symposium

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative The University of Wisconsin Comprehensive Cancer Center (UWCCC), in collaboration with the National Clinical Trials Network (NCTN), seeks to bring innovative cancer treatment trials to the population of Wisconsin and its neighboring regions to reduce the burden of cancer. Through leadership in the NCTN Cooperative group program, the UWCCC faculty are working to design the next generation of genomically-directed clinical trials, as well as those that utilize advanced imaging techniques.

PI_NAMEs: BARROILHET, LISA M;BASCHNAGEL, ANDREW MICHAEL;WILKE, LEE GRAVATT (contact);WISINSKI, KARI BRAUN

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adjuvant;Advisory Committees;Advocacy;African American;alpelisib;Amendment;American College of Radiology Imaging Network;American College of Surgeons Oncology Group;Awareness;Breast Diseases;Cancer Burden;Cancer Center;Cancer Control;cancer education;cancer health disparity;Cancer Patient;cancer prevention;cancer therapy;career;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Colorectal;Communication;Communities;Cooperative Group Program;County;data management;Dedications;design;Development;Disease;Doctor of Pharmacy;Eastern Cooperative Oncology Group;Education;Eligibility Determination;Ensure;Faculty;FOLH1 gene;gastrointestinal;Genomics;Goals;Grant;Gynecologic Oncologist;Gynecologic Oncology;Gynecologic Oncology Group;Health;Hodgkin Disease;Human;Image;Imaging Techniques;improved;Infrastructure;innovation;Intake;interdisciplinary approach;interest;Kidney;Latino;Leadership;Lesbian Gay Bisexual Transgender Queer;Lung;Lymphoma;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mantle Cell Lymphoma;Medical Oncologist;Medical Oncology;meetings;member;Metastatic breast cancer;Minority Groups;minority patient;Mission;Modernization;multidisciplinary;National Clinical Trials Network;Native Americans;next generation;novel;older patient;Oncologist;Oncology;Outcome;outreach;patient navigator;Patients;Pharmacologic Substance;Pharmacy facility;Phase;phase 3 study;Phase II/III Clinical Trial;Phase III Clinical Trials;phase III trial;Population;Population Heterogeneity;precision medicine;Preparation;Prevention;Principal Investigator;programs;Protocols documentation;Published Comment;Radiation Oncologist;Radiation Oncology;Radiation Therapy Oncology Group;recruit;Relapse;Renal Cell Carcinoma;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Role;Specialist;Strategic Planning;Structure;Surgical Oncology;Symptoms;System;theranostics;timeline;Translational Research;treatment research;treatment trial;Underrepresented Minority;underserved community;Underserved Population;Universities;University of Wisconsin Comprehensive Cancer Center;urologic;Voice;ward;Wisconsin;Work;Writing

PROJECT_TITLE: National Clinical Trials Network Research at the University of Wisconsin


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: CANTU, EDWARD ;RIZI, RAHIM R (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Address;Affect;Alveolar;Antioxidants;Appearance;aspirate;Atelectasis;Biological Markers;Blood;Blood Vessels;Brain Death;Cessation of life;Charge;Clinical;clinically relevant;conditioning;Consensus;Death Rate;Defect;Development;Diagnostic;Diagnostic Imaging;Diagnostic Procedure;diagnostic value;Disease;Donor person;Edema;effectiveness testing;end of life;Ensure;Evaluation;Exclusion;Frustration;Functional Imaging;Goals;graft dysfunction;Harvest;hemodynamics;Homeostasis;Hospitalization;Human;Image;imaging biomarker;imaging modality;imaging platform;imaging system;improved;improved outcome;Individual;Inflammatory;inflammatory marker;injured;Injury;Intervention;Ischemia;Label;Lung;Lung Diseases;lung health;Lung Transplantation;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;metabolic imaging;metabolic rate;Metabolism;Methods;Modeling;Monitor;Nature;non-invasive imaging;novel;Organ;Organ Donor;Organ Preservation;Organ Procurements;Outcome;Oxidative Stress;Patients;Performance;Perfusion;Physiology;post-transplant;pre-clinical;preservation;protective effect;pulmonary function;Pyruvate;Rattus;Real-Time Systems;Recording of previous events;Reperfusion Injury;Reporting;Resources;response;Risk;Rodent;Roentgen Rays;Role;Structural defect;structural imaging;Structure;Structure of parenchyma of lung;surgery outcome;System;Techniques;temporal measurement;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Thick;Time;Tissues;tool;Translations;transplant model;Transplant Recipients;Transplantation;Transportation;treatment strategy;trend;Uncertainty;uptake;ventilation;Ventilator-induced lung injury;Visual;Visualization;Weight

PROJECT_TITLE: Using Advanced Imaging to Improve Ex Vivo Lung Perfusion

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative  The proposed research is relevant to public health because this project will study the biointerface properties of DNA-inspired Janus base biomaterials, determine their interactions with cells and tissues, and develop them for intracellular delivery of mRNA. Thus, the proposed research is relevant to the part of NIH’s mission that seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: CHEN, YUPENG  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Anti-Inflammatory Agents;Antibodies;articular cartilage;base;Base Pairing;Behavior;Binding;Biocompatible Materials;Biodistribution;Blood Circulation Time;Cartilage Diseases;Cells;Chemicals;Clinic;Computing Methodologies;Cytoplasm;delivery vehicle;design;disability;DNA;Effectiveness;Endocytosis;endosome membrane;Endosomes;experimental study;Family;Future;Genes;Goals;Health;immunogenicity;improved;in silico;In Vitro;in vivo;Industrialization;Infiltration;Intravenous;Kidney;Kidney Diseases;Knowledge;Life;lipid nanoparticle;Liver;Messenger RNA;Methodology;Methods;Mission;Modification;Molecular;mRNA delivery;Names;nanoparticle;Nanotubes;Nature;Neurofibrillary Tangles;novel;Organism;particle;Patients;Penetration;Pharmaceutical Preparations;Polyethylene Glycols;Polymers;Process;Property;Proteins;Public Health;Publishing;Research;response;RNA;RNA delivery;Rod;self assembly;Serum Proteins;Shapes;Side;small molecule;Small RNA;Surface;Technology;technology research and development;Testing;Therapeutic;therapeutic RNA;Tissues;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular Delivery

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cardiovascular;Genetic Testing;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Hypertrophic cardiomyopathy (HCM) is a highly heritable trait that affects up to 1:200 individuals and is a common cause of sudden cardiac death; yet causal variants are identified in a minority of patients, many tests return variants of uncertain significance (VUS), and genotype-phenotype data for established genes is insufficient to inform medical care. Harmonizing data from six large biobanks, we will use sequencing data and innovative approaches we have developed that leverage segments of the genome shared due to recent common ancestry to: 1) define the contribution and clinical effects of known HCM genes, 2) assess the pathogenicity of candidate HCM gene and VUS, and 3) discover novel HCM risk loci. These aims will fill important knowledge gaps in HCM clinical genetics, improve the yield and interpretation of HCM genetic testing, and inform gene- based precision care and screening.

PI_NAMEs: BELOW, JENNIFER ;WELLS, QUINN STANTON (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Affect;Age;Age of Onset;Alleles;Arrhythmia;barrier to care;biobank;Candidate Disease Gene;candidate identification;Cardiac;Cardiology;Cardiomyopathies;Caring;causal variant;Clinic;Clinical;clinical effect;Clinical Management;Clinical Research;clinically significant;cohort;Communities;Data;data harmonization;Data Set;defined contribution;Diagnosis;Disease;disease-causing mutation;Distant;DNA;England;Enrollment;Equilibrium;European ancestry;Future;Genes;Genetic;Genetic Research;genetic testing;Genetic Variation;genome wide association study;Genomic Segment;Genomics;Genotype;Goals;Guidelines;Health;Heritability;Heterogeneity;Human Genetics;Hypertrophic Cardiomyopathy;identity by descent;improved;Individual;Informatics;innovation;Intervention;Knowledge;Link;Literature;Maps;Medical;Medical Genetics;Methods;Minority;novel;Participant;Pathogenicity;Patient Care;Patients;Penetrance;personalized care;personalized screening;phenome;Phenotype;phenotypic data;Population;proband;rare variant;Recommendation;Relative Risks;Reporting;Research;Resources;Risk;risk stratification;risk variant;Sample Size;Sarcomeres;screening;Site;sudden cardiac death;Sudden Death;Testing;trait;Uncertainty;Variant;variant of unknown significance;Work

PROJECT_TITLE: Leveraging Large-Scale Biobanks to Discover and Define Rare Variant Effects in Hypertrophic Cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The skin is a barrier site that protects us from invading microbes such as pathogenic fungi, including the recently discovered drug-resistant pathogen Candida auris. Here we will define how specific pathogen pathways and virulence factors interplay with skin-resident immune cells, their positions, and signals, to ultimately limit infection.

PI_NAMEs: MOLOFSKY, ARI B;NOBLE, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Animals;Antimicrobial Resistance;Attention;Automobile Driving;Behavior;Binding;Biological Assay;Candida albicans;Candida auris;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell secretion;Cell surface;Cells;Clinical;Communicable Diseases;CRISPR/Cas technology;Defect;Dendritic Cells;Disease;Drug resistance;drug resistant pathogen;emerging pathogen;Engineering;Epithelial Cells;Exhibits;Fibroblasts;fitness;fungal genetics;Generations;genetic linkage;Goals;Hair;Hair follicle structure;Health;Human;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunology;improved;In Vitro;in vivo;Infection;Infection Control;insight;Integration Host Factors;Interferon Type II;Interferons;Invaded;Libraries;Lymphocyte;Mediator;Microbe;Modeling;Molecular;mouse model;Mus;Mutagens;mutant;Mutation;Natural Killer Cells;pathobiont;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Persons;Play;Positioning Attribute;Production;Protein Secretion;Proteins;quantitative imaging;recruit;response;Role;Sebaceous Glands;Signal Transduction;single-cell RNA sequencing;Site;Skin;Skin colonization;Source;success;Testing;Thick;Time;Tissues;transcription factor;transmission process;Virulence;Virulence Factors;Work

PROJECT_TITLE: Pathogen and immune-topographic mechanisms that underpin Candida auris skin colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Culturally-grounded interventions are based on local AIAN values and practices and are promising forms of substance use prevention for AIAN adolescents, yet there is a dearth of studies evaluating their impact. Native Spirit (NS) is a culturally-grounded after-school program that is led by traditional knowledge holders with each session focusing on a unique cultural value and activity. The purpose of this study is to: 1) identify core elements of the NS program, 2) identify and adapt culturally-appropriate assessment measures, and 3) evaluate the impact of participation in the NS program on AI adolescent substance use, cultural identity, self- esteem, and resilience; which will add to the small, yet growing body of work on the relationship between AIAN culture and health.

PI_NAMEs: HUNTER, AMANDA M (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: 16 year old;Adolescent;Adolescent Development;adolescent substance use;Advocate;after-school program;Age;Age Years;Alaska Native;Alcohol consumption;American Indians;Arizona;Attenuated;behavior change;behavioral health;boys;Cause of Death;Collaborations;Communities;community academic partnership;community advisory board;community based participatory research;community partners;Coping Behavior;Country;cultural values;Data;Data Collection;Death Rate;design;Development;disorder prevention;drug abuse prevention;Early Intervention;early onset drug use;effectiveness evaluation;Elderly;Elements;Ethnic Origin;Evaluation;Evidence based intervention;experience;Exposure to;Faculty;Feeling suicidal;girls;Goals;Ground Substance;Health;Health Promotion;High Prevalence;improved;Indian reservation;Indigenous;Individual;innovation;Intervention;Interview;Knowledge;Measurement;Measures;member;Mental Depression;Methods;Morbidity - disease rate;National Institute of Drug Abuse;native youth;Participant;participant interview;Patient Self-Report;Phase;Positioning Attribute;Prevalence;prevent;Prevention;Prevention program;preventive intervention;Primary Prevention;programs;protective factors;Public Health;Qualitative Evaluations;Quantitative Evaluations;racial population;recruit;reduced substance use;Research;Research Personnel;Reservations;resilience;Resources;Risk Behaviors;Rural;Sample Size;self esteem;self-reported depression;skills;social;Structure;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;success;Suicide;Surveys;tenure track;theories;Time;Training;tribal community;Update;Waiting Lists;Youth

PROJECT_TITLE: Native Spirit: Culturally-grounded substance use prevention for Indigenous adolescents


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_DEPT: PATHOLOGY

PI_NAMEs: MOLOFSKY, ARI B (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 3-Dimensional;Acute Brain Injuries;Adopted;Adoption;Aging;Astrocytes;Automobile Driving;Blood Vessels;Brain;Brain Injuries;Cells;Cellular biology;Central Nervous System;central nervous system injury;chemokine;Cicatrix;Contracts;cytokine;Data;Equilibrium;Exposure to;Fibroblasts;Foundations;Functional impairment;functional loss;Future;Generations;Genetic;Genetic Transcription;Goals;Grant;Health;Human;Immune;immune activation;immune cell infiltrate;Immunity;Immunology;immunoregulation;in vivo;Infiltration;Inflammation;Inflammatory;Injury;Integrins;Interleukin-1;Invaded;Ischemic Stroke;Lesion;Lymphocyte;Lymphoid;Macrophage;Mediating;Middle Cerebral Artery Occlusion;Modeling;monocyte;mouse model;Mus;Myelitis;Myofibroblast;Nervous System Physiology;Nervous System Trauma;neuropsychiatric disorder;Neurosciences;Nuclear;Organ;Pathologic;pathological aging;Pathway interactions;Positioning Attribute;Primates;profibrotic fibroblast;programs;Proliferating;quantitative imaging;Recovery;recruit;Regulation;repaired;response;response to brain injury;Role;Signal Transduction;Site;Source;Sterility;Stromal Cell-Derived Factor 1;Stromal Cells;Supporting Cell;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptomics;Transforming Growth Factor beta;Work;wound;wound healing

PROJECT_TITLE: Distinct early and late programs of fibroblast - immune crosstalk govern functional responses to brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-V (03)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Pediatric;Pregnancy;Rare Diseases;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative In the setting of pregnancy, infection with Ebola Virus (EBOV) resulting in the Ebola Virus Disease (EVD) leads to nearly 100% loss of the fetus or neonate, with or without the additional death of the mother. This proposal seeks to evaluate the tropism of EBOV within placental tissues, transmission of EBOV across the placenta to the fetus, as well as to define the role of cell surface receptors that may influence the tissues infected or timing of placental infection and transmission. The data from this project will ultimately help us understand the barrier role of the placenta during viral infections, but also will shed light on that pathogenesis of EVD in pregnancy in order to develop therapeutics or interventions to improve outcomes for mothers and their children.

PI_NAMEs: MAURY, WENDY JEAN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Africa;Amniotic Fluid;Antigens;Automobile Driving;Binding;Biology;C57BL/6 Mouse;Cell membrane;Cell surface;Cell Surface Receptors;cell type;Cells;Cessation of life;chemokine;Child;Chorionic villi;cytokine;Data;Dendritic Cells;early pregnancy;Ebola Hemorrhagic Fever;Ebola virus;emerging virus;Endosomes;Endothelium;epidemic virus;Epithelium;Evaluation;Event;Experimental Animal Model;experimental study;fetal;Fetal Death;Fetal Development;fetal loss;Fetal Tissues;Fetus;fetus cell;Fibroblasts;Filovirus;Germ Cells;Glycoproteins;Goals;Health;Human;human morbidity;human mortality;improved outcome;Infection;Innate Immune Response;Intervention;Kinetics;Knowledge;Laboratories;late endosome;Late pregnancy;Macrophage;Maternal Mortality;maternal outcome;Maternal-Fetal Transmission;Mediating;Meta-Analysis;Modeling;Mothers;mouse model;Mus;Myeloid Cells;Neonatal Mortality;neonate;Organ;Outcome;pandemic disease;Pathogenesis;phosphatidylserine receptor;Phosphatidylserines;Placenta;placental infection;placental trophoblasts;Play;Population;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;Process;Production;Productivity;receptor;Recombinants;RNA Viruses;Role;Route;Stains;Syncytiotrophoblast;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;tissue tropism;Tissues;transmission process;trophoblast;Tropism;Vertical Transmission;Vesicular stomatitis Indiana virus;Viral;Viral Antigens;Viral Hemorrhagic Fevers;Viral load measurement;viral outbreak;Viral Pathogenesis;viral RNA;viral transmission;Virion;Virus;Virus Diseases;Virus Replication;virus tropism;Woman;Work;Zaire Ebola virus;Zika Virus

PROJECT_TITLE: Identifying placental tissue tropism and cellular mechanisms of Ebola Virus transmission from mother to fetus in pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-L (02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Hematology;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sepsis;Vaccine Related

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PUBLIC HEALTH STATEMENT In this project, we propose to test therapeutic antibodies against Pseudomonas aeruginosa as novel strategy to fight against antimicrobial resistant infections caused by this bacterium. The work resulting from this project will shed light on the mechanism of function of a novel class of antibodies and establish proof of concept preclinical data for the use of anti-P. aeruginosa therapeutic antibodies. Altogether, this project is relevant to public health and the mission of the NIH as it will generate important knowledge to improve the lives of patients affected by this antibiotic resistant bacterium.

PI_NAMEs: BARBIER, MARIETTE  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Active Immunization;Address;Affect;Age;Antibiotics;Antibodies;Antibody Therapy;Antimicrobial Resistance;antimicrobial resistant infection;Bacteria;Bacterial Antibiotic Resistance;Binding;Cell Membrane Permeability;Cells;Cellular Membrane;Centers for Disease Control and Prevention (U.S.);Cessation of life;Classification;Clinical;clinical application;Communicable Diseases;Complement;cytokine release syndrome;Data;Development;efficacy evaluation;Endotoxins;fighting;Future;Generations;Goals;healthcare-associated infections;Human;Humoral Immunities;Immune;Immune Sera;Immune system;Immunocompromised Host;Immunotherapy;improved;In Vitro;in vivo;Individual;Infection;interest;Knowledge;Laboratories;Lipopolysaccharides;Membrane;Microbial Biofilms;Mission;Monoclonal Antibodies;Multi-Drug Resistance;multi-drug resistant pathogen;multidrug-resistant Pseudomonas aeruginosa;Multiple Bacterial Drug Resistance;Mus;novel;novel strategies;novel therapeutic intervention;Passive Immunization;pathogen;Patients;Pneumonia;pre-clinical;Pre-Clinical Model;prevent;Prevention;Production;prophylactic;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Research;Resistance;response;Role;Running;Sepsis;septic patients;Serotyping;Serum;standard of care;Surface;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic evaluation;United States National Institutes of Health;Vaccinated;Vaccination;vaccine-induced antibodies;Variant;Whole Cell Vaccine;Work;World Health Organization

PROJECT_TITLE: Development of anti-LPS therapeutic antibodies for the treatment of Pseudomonas aeruginosa infections

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOLOGY

PHR: Project Narrative This project is relevant to public health because the outcomes could lead to the identification of targets for therapies that are aimed at preventing the loss of skeletal muscle mass that occurs during a variety of conditions such as bed rest, cachexia, muscular dystrophies, myopathies, immobilization, and aging.

PI_NAMEs: HORNBERGER, TROY A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Aging;Bed rest;Biochemical;Biogenesis;Biopsy;Cachexia;Cell fusion;Cell Nucleus;Cell Proliferation;disorder prevention;Dissociation;Event;experimental study;Fiber;FRAP1 gene;Future;gene therapy;genetic corepressor;Genetic Transcription;Goals;Growth;Human;Hypertrophy;Immobilization;insight;Knockout Mice;LacZ Genes;Link;Maintenance;mechanical load;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Mediating;mimetics;Molecular;Mus;Muscle;muscle form;Muscle satellite cell;Muscular Dystrophies;mutant;Mutation;Myoblasts;Myopathy;novel;Outcome;Pathway interactions;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;prevent;Process;Protein Biosynthesis;Public Health;Quality of life;Regulation;Reporting;Research;resistance exercise;response;Ribosomes;Role;Sampling;Scaffolding Protein;Serine;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;targeted treatment;Testing;transcription factor;Transfection;Translating;Translations;TRIM Motif

PROJECT_TITLE: The Role of TRIM28 Phosphorylation in the Mechanical Regulation of Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Recent investigation into non-coding RNAs (ncRNAs) have revealed a wide range of key functions in both cellular and organismal processes. However, while the field has focused on identification of ncRNAs and molecular mechanisms, their diverse in vivo functions are only beginning to emerge. Therefore, this conference program was designed to reveal these essential functions of ncRNAs to fill this knowledge gap and to connect their modes of action with biological outcomes that promise new insights and potential opportunities for therapeutic development.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TITLE: Non-coding RNA Biology: New Roles & Diversity

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The proposed studies will elucidate the molecular mechanism of the MEIG1 complex in mammalian spermiogenesis and fertilization. The studies will for the first time dissect the functional relationships of a macromolecular complex in the manchette essential for spermiogenesis and establish an in vivo system to study IMT. In addition, the studies will also reveal a novel mechanism in spermatid chromatin remodeling for normal fertilization and embryogenesis.

PI_NAMEs: HAMMOUD, SAHER SUE;KELLY, CHRISTOPHER V;ZHANG, ZHIBING  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Amino Acids;Antigens;Binding;Cell Nucleus;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Chromosome Mapping;Comet Assay;comparative;Complex;contraceptive target;Cytoplasm;Defect;DNA Damage;driving force;Dynein ATPase;Embryonic Development;Failure;Fertilization;Flagella;Fluorescence;gene interaction;Genes;Genetic Materials;Genome;Germ Cells;Histones;in vivo;Injections;Intracytoplasmic Sperm Injections;Knock-in Mouse;Knock-out;Knockout Mice;Light;Macromolecular Complexes;male;Male Contraceptive Agents;Male Infertility;Mediating;Meiosis;Microtubules;Mitosis;Modeling;Molecular;Motor;mouse model;Mus;mutant mouse model;Mutant Strains Mice;Mutation;novel;Nuclear;Nuclear Proteins;Parkin;Pattern;Phase;Phenotype;Physical condensation;Play;Probability;Process;protein complex;protein transport;Proteins;Proteomics;recruit;Research;Role;sperm cell;Sperm Head;Sperm Tail;Sperm Transport;Spermatids;Spermatocytes;Spermatogenesis;Spermiogenesis;Structure;System;Testing;Time;Transport Process;Visualization;zygote

PROJECT_TITLE: The mechanisms of MEIG1 complex in mammalian spermiogenesis and fertilization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Sleep Research

ORG_DEPT: DERMATOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT / PROJECT NARRATIVE: The 2024 PASPCR Conference in New York City will bring together investigators studying pigmentary disorders including those disproportionately affecting persons with skin of color such as vitiligo, genetic pigmentation syndromes, and melanoma. The theme of the conference - “Where pigment cell research never sleeps” - is relevant to public health as the conference will disseminate the latest findings on the etiology, treatment, and prevention of disorders and malignancy of pigment cells. Through formal mentorship opportunities, the conference will foster the participation of young investigators, especially women and underrepresented minorities.

PI_NAMEs: ZIPPIN, JONATHAN HALE (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;Albinism;American;Americas;Animal Model;Area;Asian;Benign;Biology;career;Cells;Cellular biology;Chemistry;Clinical;Communities;Dedications;Development;Developmental Biology;Developmental Cell Biology;Disease;disorder prevention;Education;Ensure;equity, diversity, and inclusion;Etiology;European;experience;Faculty;Fostering;Foundations;Genetic;Genome;Genomics;Goals;Health;health disparity;Human;human tissue;Immunologist;Industry;interest;International;Japanese;Knowledge;Leadership;Light;Malignant - descriptor;Malignant Neoplasms;meetings;Melanins;melanocyte;Melanoma;member;Mentors;Mentorship;New York City;patient population;Patients;Persons;Photobiology;photoprotection;Pigmentation physiologic function;Pigments;Prevention;programs;Public Health;public health relevance;Research;Research Personnel;response;Role;Science;Scientist;skin color;skin disorder;Sleep;Societies;Spain;stem cell biology;Stimulus;Structure;Students;success;symposium;Syndrome;Underrepresented Minority;Vitiligo;Vocational Guidance;Woman

PROJECT_TITLE: The PanAmerican Society for Pigment Cell Research (PASPCR) 25th annual conference entitled "Where pigment cell research never sleeps"

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cancer;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE About 10-15% of prostate cancers have mutations in the SPOP gene, leading to altered androgen receptor signaling and increased sensitivity to therapies targeting this pathway, but other components of this pathway and their impact on prostate cancer development and treatment remain largely unknown. Our collaborative team has identified new upstream regulator and downstream effectors of this signaling pathway and developed novel strategies to target them, potentially successfully treating advanced cancers. Successful completion of this project will define key signaling pathways leading prostate cancer development and establish novel therapeutic approaches.

PI_NAMEs: BARBIERI, CHRISTOPHER E;ZHOU, PENGBO  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Androgen Receptor;androgen sensitive;Automobile Driving;Biological;Biological Markers;Biological Models;Biology;Cancer Biology;Cells;Characteristics;Chromatin;Clinical;Clinical Trials;clinically relevant;cofactor;Data;Dependence;Development;Disease;DNA Sequence Alteration;Elements;EP300 gene;Event;Foundations;G3BP1 gene;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Growth;Hand;Hormones;Human;human data;In Vitro;in vivo;in vivo Model;inhibitor;innovation;insight;Malignant neoplasm of prostate;Malignant Neoplasms;Missense Mutation;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;Mutation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;overexpression;Pathway interactions;Patients;pharmacologic;Phenocopy;Phenotype;Precision therapeutics;predictive marker;programs;Prostate;Prostate Cancer therapy;prostate carcinogenesis;rational design;receptor function;Receptor Signaling;Recurrence;Regimen;Regulation;Role;Sampling;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;standard of care;System;targeted treatment;Therapeutic;therapeutic target;therapy resistant;tool;translational study;treatment response;tumor;tumorigenesis;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Increasing evidence reveals that unhealthy diet induced metabolic disorders in mammals can be transmitted from father to offspring via sperm RNAs. Understanding of how sperm RNA and their modifications regulate offspring health through embryo development would potentially guide interventions to mitigate the risk of transgenerational transmission of diet-related disorders.

PI_NAMEs: CHEN, QI  (contact);MILSTONE, DAVID S;ZHOU, TONG

PROJECT_TERMS: Address;Adult;Adult Children;Aging;Biogenesis;Biological Process;Cell Lineage;Cell Nucleus;Cells;Code;Coin;Complex;Data;Detection;Development;Diet;dietary;Disease;DNA Sequence;Embryo;embryo cell;Embryonic Development;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Equilibrium;Event;Exhibits;experience;Fathers;Fetus;Funding;Future Generations;Genetic Transcription;Health;High Fat Diet;Inflammation;Injections;Inner Cell Mass;innovation;insight;intergenerational;Intervention;Late pregnancy;Mammals;Maps;Mass Spectrum Analysis;Measures;Mediating;Memory;Messenger RNA;Metabolic;Metabolic Diseases;metabolic phenotype;Methods;Methyltransferase;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;Mus;novel;Nuclear;offspring;Onset of illness;Outcome;Penetration;Phenotype;Placenta;Placentation;Pregnancy;preimplantation;prevent;Process;Regulation;Research;Research Personnel;Ribonucleoproteins;Ribosomal Biogenesis Pathway;Ribosomal RNA;Ribosomes;risk mitigation;RNA;RNA Binding;Role;sex;Shapes;Site;Small RNA;Specificity;sperm cell;Sperm Head;stem cell model;Stress;tool;trait;transcriptome sequencing;Transfer RNA;transmission process;Unhealthy Diet;United States National Institutes of Health;Untranslated RNA;Weight

PROJECT_TITLE: Sperm tsRNAs/rsRNAs and their RNA modifications in diet-induced epigenetic inheritance


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lymphatic Research;Neurosciences;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE West Nile virus (WNV) is an emerging mosquito-borne virus that globally causes annual epidemics of virus- induced encephalitis. We seek to build a comprehensive single cell atlas of WNV infection in the lymphatics and spleen to understand the targets of infection, cell dynamics, and how the virus disseminates throughout the host. Since there are no approved vaccines or specific antivirals to combat WNV, identifying the precise cellular targets of infection in the periphery could be leveraged engineer a targeted approach for restricting WNV infection.

PI_NAMEs: SUTHAR, MEHUL SHAMAL (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Alpha Virus;Anatomy;Anti-viral Agents;Anti-viral Response;Arboviruses;Atlases;Biological Assay;Brain;C57BL/6 Mouse;Cell Communication;cell type;Cells;cellular targeting;Cellular Tropism;Central Nervous System;Cervical;Color;combat;Critical Pathways;Dendritic Cells;Development;Dimensions;Disease;draining lymph node;Encephalitis;Engineering;epidemic virus;Event;Flavivirus;Flow Cytometry;Frequencies;Future;Gene Expression Profile;Genetic Transcription;genomic platform;Genomics;Heterogeneity;Human;Immune;immune cell infiltrate;Immune response;Immunocompetent;Immunology;in vivo;Infection;Infection prevention;Innate Immune Response;innovation;insight;interdisciplinary approach;interest;Investigation;keratinocyte;Location;lymph nodes;Lymphatic;Lymphoid Tissue;Macrophage;Measurement;Methodology;Methods;Modification;Molecular;Molecular Biology;mosquito-borne;Mosquito-Borne Encephalitis;mouse model;Myelogenous;Neurocognitive;Neurologic;Neurons;neurotropic;novel;Orthobunyavirus;Outcome;Pathogenesis;Pathway interactions;Peripheral;Phase;Population;Population Analysis;Protocols documentation;Resolution;response;RNA;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Skin;Spleen;Survivors;Systems Biology;targeted treatment;Techniques;Technology;tick-borne;tool;transcriptome;transcriptomics;type I interferon receptor;United States;Vaccines;Vector-transmitted infectious disease;Viral;Viral Pathogenesis;virology;Virus;Virus Diseases;Virus Replication;West Nile viral infection;West Nile virus;Zika Virus

PROJECT_TITLE: Defining West Nile virus infection of the lymphatics using single cell techniques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PI_NAMEs: DANCIK, VLADIMIR  (contact)

PROGRAM_OFFICER_NAME: BECK, TYLER

PROJECT_TERMS: Address;Advisory Committees;Binding;Biological;Biology;Cells;Chemicals;Communication;Complex;Data;data access;Data Analyses;data exploration;Data Set;data translator;Databases;Development;Discipline;Disease;diverse data;experience;experimental study;Face;Gene Expression;Genes;Genetic Code;genetic variant;interest;Knowledge;Methods;Modeling;Molecular;molecular scale;Names;novel therapeutics;outreach;Pathway interactions;Phenotype;Positioning Attribute;Post-Translational Protein Processing;Process;Production;protein protein interaction;Proteins;prototype;Provider;Research Personnel;Resources;Science;screening;side effect;small molecule;Source;Structure;Surface;System;Systems Biology;Terminology;Toxic effect;Translations;Vision;web-based tool

PROJECT_TITLE: A Translator Knowledge Provider for Systems Chemical Biology


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The adaptive mechanisms that enable pathogenic fungi to survive the environment-to-host transition and cause persistent human disease are not well understood. In the pathogenic fungus Cryptococcus deneoformans, we have discovered transposon mobilization as a significant cause of mutation during murine infection and in response to heat stress in culture, with the potential to enhance pathogenic traits or enable antifungal drug resistance. In this study, we seek to define the mechanism of stress-induced transposon mutagenesis in C. deneoformans and to determine whether this adaptive genetic strategy contributes to enhanced pathogenesis or drug resistance in disease-causing cryptococcal species during host infection.

PI_NAMEs: GUSA, ASIYA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Aneuploidy;anti-fungal agents;Area;Aspergillus;base;Biological Assay;Brain;Candida;causal variant;Cessation of life;Chemicals;Clinical;Cryptococcal Meningitis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Death Rate;Disease;DNA;DNA Insertion Elements;DNA Methylation;DNA Sequence Alteration;DNA Transposable Elements;DNA Transposons;drug isolation;Drug resistance;Elements;Environment;environmental stressor;Evolution;FK506;Flucytosine;Frequencies;Fungal Drug Resistance;fungus;Gene Expression;gene function;genetic approach;Genetic Variation;Genome;genome sequencing;genome-wide;Genomic DNA;Genomics;Goals;Growth;Heat Stress;Heat-Shock Response;High temperature of physical object;HIV/AIDS;Human;human disease;Immune;Immune system;Immunocompromised Host;In Vitro;in vivo;Induced Mutation;Infection;Inhalation;insertion/deletion mutation;Invertebrates;Life;Lung;Maps;Mediating;Meningitis;Modeling;Molecular Chaperones;mouse model;Movement;Mus;Mutagenesis;mutant;Mutation;Mycoses;next generation;novel;Organ;Organism;Oxidative Stress;Pathogenesis;pathogenic fungus;Pathogenicity;Patient-Focused Outcomes;Patients;Pharmacotherapy;Phenotype;Population;Recurrence;Relapse;Reporter;Reporter Genes;Reporting;Research;response;Retrotransposon;RNA Interference;Role;Serial Passage;Sirolimus;Site;Stress;System;Temperature;tool;trait;transposon/insertion element;Variant;Virulence;Waxes;whole genome;Yeast Model System;Yeasts

PROJECT_TITLE: Stress-induced transposon mobilization in the human fungal pathogen Cryptococcus

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE: Aberrations in epithelial barrier repair underlie multiple diseases, from IBD to CRC. Both microbes and dietary nutrients are implicated in disease pathogenesis; however, precise underlying mechanisms remain unknown. The proposed work will provide molecular and cellular insights into how gut bacteria promote tissue regeneration by regulating cellular vitamin A metabolism and T-cell responses.

PI_NAMEs: VAISHNAVA, SHIPRA  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: adaptive immunity;antigen processing;Applications Grants;Bacteria;Beta Carotene;Cell Death;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Colitis;Collaborations;commensal bacteria;comparison control;Cues;Data;Defect;Diet;dietary;Dietary Intervention;Disease;effector T cell;enteric infection;enteric pathogen;Enterocytes;Epithelial Cells;Epithelium;epithelium regeneration;Esters;Funding;Genes;gut bacteria;gut microbiome;gut microbiota;Health Promotion;Homeostasis;host microbiome;Immune;Immune response;Immunity;immunoregulation;Infection;infection burden;insight;Interferon Type II;interleukin-22;intestinal crypt;intestinal epithelium;Intestinal Mucosa;intestinal villi;Intestines;Investigation;Lymphocyte;Mediating;Metabolic;Metabolism;Microbe;microbial;microbial host;microbiome;microbiota;Micronutrients;Molecular;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Natural Immunity;Natural regeneration;novel;Nutrient;overexpression;pathogen;Pathogenesis;Pathway interactions;Physiology;Play;Predisposition;Process;Production;Proliferating;Regulation;repaired;Reporting;response;Role;Signal Transduction;Small Intestines;Source;stem cell niche;stem cells;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;tissue regeneration;Tissues;transcriptome sequencing;Tretinoin;uptake;Vitamin A;Vitamin K;Vitamins;Work

PROJECT_TITLE: Vitamin A metabolism at the host-microbiome interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Most adults worldwide are infected by EBV and KSHV. These viruses play complex co-factor roles in a variety of malignancies, including Burkitt, Hodgkin, post-transplant, T/NK and pleural effusion lymphoma, multicentric Castleman’s disease, Kaposi’s sarcoma, nasopharyngeal and gastric carcinoma. This conference will discuss recent advances in the KSHV and EBV fields, including host/virus interactions, immune responses to EBV/KSHV and opportunities for novel vaccine and therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Adult;Africa;American;Applications Grants;Asia;Autoimmunity;Biology;biopharmaceutical industry;Biotechnology;Boston;cancer therapy;Clinical;cofactor;Collaborations;Complex;cost;Data;data exchange;Development;Discipline;Disease;Educational workshop;Epidemiology;Europe;Fees;Fostering;Foundations;Funding;gammaherpesvirus;Gene Expression;Goals;Herpesviridae;HIV/AIDS;Hodgkin Disease;Human;human disease;Human Herpesvirus 4;Human Herpesvirus 8;Immune response;Individual;Infection;Infectious Agent;innovation;International;Joints;Kaposi Sarcoma;Knowledge;Lymphocryptovirus;Lymphoma;Malignant Neoplasms;meetings;member;Mission;Multicentric Angiofollicular Lymphoid Hyperplasia;Murine herpesvirus 68;Nasopharynx Carcinoma;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;North America;novel;novel therapeutic intervention;novel vaccines;Ohio;Oncogenic;Oral;Participant;Pathogenesis;Patients;Pharmacologic Substance;Play;Pleural effusion disorder;post-transplant;Postdoctoral Fellow;posters;pre-doctoral;Prevention strategy;reactivation from latency;Reagent;Request for Applications;Research;Research Personnel;Rhadinovirus;Rhesus;Role;Rotation;Saimiriine Herpesvirus 2;Site;Societies;Stomach Carcinoma;symposium;Therapeutic Intervention;Time;Travel;Underrepresented Minority;underserved area;United States National Institutes of Health;vaccination strategy;vaccine development;Viral Cancer;Viral Genes;Viral Pathogenesis;virology;Virus;Virus Diseases;Virus Latency;virus related cancer

PROJECT_TITLE: Epstein-Barr Virus/Kaposi Sarcoma Associated Herpesvirus 2024 Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-E (M1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE  Patient genome sequencing has revealed germline genetic variation in human DDX41 as one of the most frequent genomic alterations implicated in generating a predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). DDX41 encodes an RNA helicase that regulates RNA splicing, senses double- stranded DNA, operates in cGAS-Sting signaling pathway, and promotes innate immunity. We will innovate a system to discriminate benign from pathogenic DDX41 alleles, advance clinical genetic translation, and develop foundational studies on a novel connection between DDX41 and a kinase that regulates RNA splicing.

PI_NAMEs: BRESNICK, EMERY H (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;Alleles;Alternative Splicing;Benign;Biochemical;Biological;Biological Process;Biology;Bone marrow failure;cell type;Cells;Classification;Clinical;Clinical Data;disease-causing mutation;Disparate;DNA Sequence Alteration;ds-DNA;Dysmyelopoietic Syndromes;Erythroid;Erythroid Cells;Flow Cytometry;Foundations;Functional disorder;Future;Genetic;genetic variant;Genetic Variation;Genome engineering;genome sequencing;Genomic approach;Germ Lines;Hematology;Hematopoietic stem cells;Human;Immunology;innovation;insight;Introns;Investigation;Link;Logic;Logistic Regressions;loss of function;Machine Learning;Medical Genetics;Membrane Proteins;Messenger RNA;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;Natural Immunity;novel;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Predisposition;progenitor;Protein Isoforms;Proteins;Proteomics;RNA;RNA Helicase;RNA Splicing;Signal Pathway;Stimulator of Interferon Genes;STY kinase;Susceptibility Gene;System;Tertiary Protein Structure;Testing;training data;Transcript;transcriptome sequencing;transcriptomics;translational genetics;Untranslated RNA;Variant;variant of unknown significance

PROJECT_TITLE: Discriminating Pathogenic from Benign Alleles of Myelodysplastic Syndrome Predisposition Genes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Several recent genetic studies have implicated a protein called Par3 in Alzheimer’s disease (AD) and related tauopathies. We recently found in aging and AD brains, there is a loss of Par3, and forebrain loss of Par3 causes age-dependent cellular and cognitive defects similar to AD. Our proposed studies will further elucidate the signaling mechanisms of Par3 relevant to AD progression, which will shed light on the pathogenic mechanisms of AD and can potentially lead to novel therapeutic strategies.

PI_NAMEs: ZHANG, HUAYE  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;age related;age related changes;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Autophagocytosis;Autophagosome;Axon;Behavioral;beta secretase;beta-site APP cleaving enzyme 1;Binding;Binding Proteins;Biochemical;Biological Assay;Brain;Cell Polarity;Cognitive deficits;conditional knockout;Data;Defect;Dendrites;disease phenotype;Disease Progression;Epithelium;Exocytosis;Fluorescence Resonance Energy Transfer;Frequencies;Genes;Genetic study;Hippocampus;Human;Image;imaging approach;Imaging Techniques;Impaired cognition;in vivo;Knock-in;Knock-in Mouse;Link;Longevity;Malignant Neoplasms;Microtubule Bundle;Microtubules;middle age;Modeling;Molecular;molecular imaging;mouse model;Mus;mutant;Neurons;novel;novel therapeutic intervention;optogenetics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Permeability;phosphoproteomics;Prosencephalon;Proteins;Regulation;restoration;Risk Factors;risk variant;Role;Signal Transduction;stem cell division;superresolution imaging;Synapses;tau Proteins;Tauopathies;Testing;trafficking;Transmembrane Transport;Work

PROJECT_TITLE: Polarity dysregulation in Alzheimer’s disease

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Ethnic and racial sexual minority men from socioeconomic marginalization are disproportionately affected by HIV and HIV-related comorbidities. Efforts to mitigate risk in under-resourced communities remains a challenge. This proposal seeks to shift the traditional paradigm of patient education by using virtual technology to preemptively target interconnected HIV-related comorbidities uniquely affecting sexual minority men as a means to achieve health equity through prevention education and clinical/community-based, problem-solving research, which are NIMHD priority areas.

PI_NAMEs: KERSHAW, TRACE S;RAMOS, SILVIA RAQUEL  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Affect;Age;AIDS prevention;Area;Behavior Therapy;Behavioral;behavioral clinical trial;Bisexual;Black race;Blood Glucose;Blood Pressure;Blood Vessels;Body mass index;cancer risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;catalyst;Chest Pain;Cholesterol;Chronic;Chronic Disease;Clinical;clinical practice;clinical risk;Clinical Trials;Communities;comorbidity;control trial;Counseling;Data;Diet;Disadvantaged;Discrimination;Disparity;disparity gap;distrust;Educational process of instructing;efficacy evaluation;eHealth;Equity;Ethnic Origin;experience;Follow-Up Studies;Funding;Gays;gender minority group;General Population;Goals;Health;health equity;Heart;Heart Diseases;Heterosexuals;high risk men;HIV;HIV Infections;Homophobia;Hypertension;immune activation;improved;Incidence;Income;Individual;Inequity;Inflammation;innovation;Intervention;Intervention Studies;Latinx;LGBT Health;Literature;Malignant Neoplasms;marginalization;Medical;medically underserved population;Methods;Minority Groups;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;nicotine exposure;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patient Education;Patients;Persons;Physical activity;Policies;Population;Poverty;prevent;Prevention;Prevention education;Preventive screening;Problem Solving;process evaluation;Psyche structure;Quality of Care;Quality of life;Race;racism;Reporting;Research;Resources;Risk;Risk Factors;risk mitigation;risk sharing;Scientific Advances and Accomplishments;sexual minority group;sexual minority men;Sleep Deprivation;social determinants;social health determinants;social stigma;social stressor;Social support;socioeconomics;Structure;Technology;Testing;transphobia;United States National Institutes of Health;Violence;Viral Load result;virtual environment;virtual technology;Virtual Tool;Waiting Lists

PROJECT_TITLE: Theoretically Informed Behavioral Intervention to Enhance QOL and Prevent HIV-related Comorbidities in Ethnic and Racial Sexual Minority Men

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 IN (M1)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Members of the human microbiota have been shown to play an important role in cancer initiation and progression, but the underlying mechanisms remain largely unknown. Building on novel insights from published and preliminary studies in bacterial epigenetics, mammalian epigenetics, and cancer microbiome research, we propose that bacterial enzymes called DNA methyltransferases, which are abundant within the human microbiota, can drive colon cancer development by promoting bacterial virulence as well as modify the human cell genome. If successful, we will uncover a novel host-microbe interaction that could be targeted for disruption as a strategy to prevent or treat cancer

PI_NAMEs: JOHNSTON, CHRISTOPHER D (contact);TING, ANGELA H

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Animal Model;Antibiotics;ApcMin/+ mice;Bacteria;Bacterial DNA;Bacterial Genes;Biological Assay;cancer cell;cancer initiation;cancer prevention;carcinogenesis;Cell Culture Techniques;Cell Cycle;Cell model;Cells;Chemicals;Clinical;clinically relevant;Coculture Techniques;Collection;Colon;colon cancer cell line;Colon Carcinoma;Colorectal;Colorectal Adenocarcinoma;Colorectal Cancer;colorectal cancer prevention;Complex;Data;Defect;demethylation;design;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNA Modification Process;DNA Restriction-Modification Enzymes;Ectopic Expression;efficacy evaluation;Engineering;Enzymes;Epigenetic Process;epigenome;Epithelial Cells;Experimental Animal Model;experimental study;Fusobacterium nucleatum;gastrointestinal;Gene Expression;Gene Expression Regulation;Genetic;Genetic Engineering;Genetic Transcription;Genome;Genome Stability;Genomics;Growth;host colonization;host-microbe interactions;Human;human DNA;Human Genome;human microbiota;human pathogen;Hypermethylation;immunoregulation;In Vitro;in vivo;Individual;inhibitor;insight;Invaded;Knowledge;Lower Gastrointestinal Tract;Malignant Neoplasms;member;Metabolic;Methylation;methylome;Microbe;microbial;Microbial Biofilms;microbiome research;microbiota;microorganism;Modeling;Modification;mouse model;mutant;Names;Normal tissue morphology;novel;Nuclear;Oncogenes;Oncogenic;Oral;Oral cavity;oral microbiome;Organoids;pan-genome;pathogen;pathogenic bacteria;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Pre-Clinical Model;premalignant;prevent;Process;Proteins;Publishing;Research;Role;small molecule inhibitor;Specificity;Specimen;subcutaneous;System;Testing;therapeutic target;tool;transcriptome;tumor;Tumor Burden;tumor microbiota;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;Virulence;Work

PROJECT_TITLE: Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: The incorporation of genetics and genomics into medical care and the public domain raises new challenges for how we understand privacy and identity, concepts that have long been closely linked in American discourse. The Genetic Privacy and Identity in Community Settings (GetPreCiSe), an NHGRI Center of Excellence in Ethical, Legal, and Social Implications Research (CEER) will 1) characterize how social practices and genetic data access affect notions of genetic privacy and identity, 2) assess the impact of emerging laws and regulatory frameworks in the US and abroad, and 3) gauge how new technologies compromise but also uphold protections.

PI_NAMEs: CLAYTON, ELLEN WRIGHT;MALIN, BRADLEY A. (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Administrative Supplement;Advertising;Affect;Age;All of Us Research Program;American;Area;Artificial Intelligence;artificial intelligence model;Behavior;behavior influence;behavioral economics;Big Data;blockchain;California;Caring;Clinical;cohort;Communities;community setting;computerized data processing;Conceptions;Conflict (Psychology);Data;data access;Data Collection;data privacy;Data Protection;Data Security;data sharing;Deposition;design;Development;Electronic Health Record;Engineering;Environment;ethical, legal, and social implication;European Union;Family;Film;Gender;Genetic;Genetic Identity;genetic information;Genetic Models;Genetic Privacy;Genetic study;genetic testing;genomic data;Genomics;Growth;Health;Imagination;Individual;Infrastructure;innovation;insight;interest;International;Internet;Investigation;Knowledge;Law Enforcement;Laws;Legal;legal implication;Link;Literature;Marketing;Medical;meetings;Methods;minimal risk;multidisciplinary;multimodality;National Human Genome Research Institute;new technology;news;Newspapers;next generation;Participant;Perception;Persons;Policies;Privacy;Provider;Public Domains;Publications;Race;Radio;Regulation;Research;Research Personnel;Risk;Role;Services;sex;social;social media;Social Network;Social Sciences;Societies;Technology;Television;Testing;Time;Training;United States;United States National Institutes of Health;Use of New Techniques;Visual;Work

PROJECT_TITLE: Genetic Privacy and Identity in Community Settings: CEER Final Meeting Administrative Supplement


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Nanotechnology;Wound Healing and Care

ORG_CITY: NEWARK

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

PHR: Narrative This proposal aims to determine how phothothermal core@shell, cage and frame nanoparticles can affect virulent biofilms and prevent or treat infectious diseases. These unique anti-biofilm agents, which can be tailored in size and composition to yield different plasmonic properties, can effectively destroy the polymeric matrices of biofilms under illumination by NIR light and kill bacteria in less than a minute. The acquired knowledge is expected to have a profound impact on advancing public health and clinical therapies of biofilms.

PI_NAMEs: HAJFATHALIAN, MARYAM  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Ablation;Acceleration;Affect;Animal Model;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Architecture;Area;Award;Bacteria;Behavior;Binding;biomaterial compatibility;Bladder;Body Surface;Cardiovascular Diseases;career;career development;Cells;chemical property;Chemistry;chronic infection;Clinical;colloidal nanoparticle;Communicable Diseases;Competence;Complex;Contrast Media;Data;Dental Alloys;Dental caries;Dermatology;design;Development;Devices;Disease;disorder control;Drug Delivery Systems;Effectiveness;Elements;Engineering;Excision;experience;experimental study;Exposure to;extracellular;Extracellular Matrix;flexibility;fluorescence imaging;Formulation;Fostering;Generations;Goals;Heart Valves;Image;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Infection;Infectious Skin Diseases;innovation;irradiation;Knowledge acquisition;Laboratory Research;Lasers;Light;light effects;Lighting;Lung;Malignant Neoplasms;Mediating;medical implant;Mentors;metallicity;Metals;Methods;microbial;Microbial Biofilms;microorganism;Morphology;Mouth Diseases;multidisciplinary;nano;nanocage;nanocrystal;nanomaterials;nanomedicine;nanoparticle;nanoshell;Nanostructures;Nanotechnology;nanotherapeutic;New Agents;novel;oral infection;oral pathogen;Organ;Orthodontics;pathogen;Patients;Pennsylvania;Phase;photoacoustic imaging;photothermal therapy;physical property;plasmonics;Polymers;post-doctoral training;prevent;Process;Property;Public Health;Radiology Specialty;Reporting;Research;Research Activity;Research Proposals;Resolution;Resources;Rodent;Rodent Model;Safety;Scientist;Shapes;skills;Skin;skin disorder;Skin Tissue;soft tissue;Staphylococcus aureus;Streptococcus mutans;Structure;Surface;Techniques;Testing;Therapeutic;Therapeutic Studies;Thermal Ablation Therapy;time interval;Tissues;Tooth structure;Training;Training Programs;Transition Elements;Treatment Cost;Universities;Virulent;wound;wound healing;Wound Infection;Wound models;X-Ray Computed Tomography

PROJECT_TITLE: Anti-biofilm laser-mediated photothermal ablation via complex noble metal nanostructures


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We will create a subunit vaccine against SARS-CoV-2 that contains BcfA and alum as combination adjuvants and the SARS-CoV-2 Spike, M and N proteins as antigens. We will define the immune correlates of protection that elicit productive systemic and mucosal immune responses and provide long-lasting protection against SARS-CoV-2 infection.

PI_NAMEs: DEORA, RAJENDAR K;DUBEY, PURNIMA  (contact);OESTREICH, KENNETH JOSEPH

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Adjuvant;Adoptive Transfer;Adult;aluminum sulfate;Animal Model;Antibodies;Antibody Response;Antigens;Attenuated;Avidity;Blocking Antibodies;Bordetella;Bordetella pertussis;CD8B1 gene;Cell secretion;Cells;COVID-19 vaccine;cytokine;Data;Development;experimental study;factor A;Formulation;Generations;Helper-Inducer T-Lymphocyte;Human;Humoral Immunities;IL17 gene;Immune;Immune response;Immunity;Immunization;Immunoglobulin Class Switching;improved;Infection;Inflammatory;Interferon Type II;interleukin-21;Intramuscular;K-18 conjugate;Knockout Mice;Laboratories;Location;Lung;Mediating;Memory;Memory B-Lymphocyte;Mesocricetus auratus;Messenger RNA;Modeling;Mouse Strains;Mucosal Immune Responses;Mucosal Immunity;mucosal vaccination;mucosal vaccine;Mucous Membrane;Mus;Mutation;Mycobacterium tuberculosis;Nature;neutralizing antibody;Nose;novel;Nucleocapsid;parenteral administration;pathogen;pathogenic bacteria;pathogenic virus;Pathology;Phenotype;Play;Population;Production;Productivity;Property;protective efficacy;Proteins;Publishing;Regimen;respiratory;respiratory pathogen;Respiratory System;response;Role;Route;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Shapes;Structural Protein;Structure of germinal center of lymph node;Subunit Vaccines;T cell response;T memory cell;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Transgenic Organisms;translational impact;vaccination strategy;vaccine delivery;Vaccine Design;vaccine efficacy;vaccine-induced immunity;Vaccines;Variant;variants of concern;Viral;Viral Proteins;Work;Yersinia pestis

PROJECT_TITLE: Mucosal subunit vaccines against SARS CoV-2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (02)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: The proposed research is relevant to public health and the Veterans Health Administration because stroke and its associated direct and indirect costs are one of the top healthcare costs annually. Stroke is a life-altering event that causes varying amounts of functional impairment that requires complex, chronic disease management at both the system and individual level. Ensuring Veterans have access to appropriate rehabilitation services at the system level, and the development of tailored behavioral interventions to help promote disease self-management at the individual level, are two critical components of post-stroke function. This can have an outsized impact on long-term morbidity and quality of life. This research proposal seeks to create building blocks for interventions at the health system and individual levels to improve the complex, chronic disease management and function for older Veterans post-stroke.

PI_NAMEs: WADDELL, KIMBERLY  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;acute stroke;Address;Adherence;Age Years;Aging;Area;behavior change;Behavior Therapy;behavioral economics;Behavioral Sciences;care delivery;care outcomes;career;Caregivers;Caring;Characteristics;Chronic;Chronic Care;Chronic Disease;chronic neurologic disease;cohort;Communities;Community Healthcare;community reintegration;Complex;critical period;Data;Data Sources;Dependence;design;Development;Direct Costs;disability;Disease;Disease Management;efficacy testing;Enrollment;Ensure;Equipment and supply inventories;Evaluation;Event;Exclusion;exercise intervention;experience;Facilities and Administrative Costs;Foundations;Functional impairment;functional improvement;functional outcomes;functional status;Goals;Health;Health Care Costs;health care disparity;health care service utilization;Health Services Accessibility;Health system;Home;hospital readmission;human old age (65+);Impairment;improved;Individual;Individual Differences;innovation;Inpatients;insight;Intervention;Intervention Trial;Interview;intrinsic motivation;Life;Link;Long term disability;Long-Term Care;Medical;Medicare;Methodology;military veteran;Modeling;Morbidity - disease rate;Mortality Decline;Motivation;multidisciplinary;Needs Assessment;novel;nursing skill;Obesity;Outcome;Participant;Physical activity;pilot test;Population;post stroke;preference;prevent;primary outcome;Process;programs;Public Health;Quality of life;Quantitative Evaluations;Recording of previous events;Recovery;rehabilitation service;Rehabilitation therapy;remote intervention;remote technology;Research;Research Priority;Research Proposals;Residual state;Rural;Rural Health;Sampling;Self Care;Self Management;skills;Standardization;Stroke;Stroke prevention;stroke symptom;stroke therapy;Structure;System;therapy design;Training;Transportation;Veterans;Veterans Health Administration;wearable device;Work

PROJECT_TITLE: Enhancing function for Veterans post-stroke at the system and individual level

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Pediatric;Substance Misuse

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative – no change from original  Rates of cannabis use are rising across the US, yet little is known about its long-term effects, in part due to a lack of translationally relevant animal models of cannabis use. The goals of this proposal are to establish pharmacokinetic properties of ∆9-tetrahydrocannabinol following acute cannabis vapor delivery and test the feasibility of cannabis vapor self-administration in inbred and outbred strains of male and female mice during adolescence and adulthood.

PI_NAMEs: DELEVICH, KRISTEN MARIE;HAYASHI, KANAKO ;MCLAUGHLIN, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acute;addiction;Address;Adolescence;Adolescent;Adult;Age;alcohol and other drug;Animal Model;Animals;Behavior;Behavioral;Biological;Biological Factors;Brain;cannabimimetics;Cannabinoids;Cannabis;cannabis seeking;cannabis use behavior;Catheterization;cell type;Cells;Cognitive;Communities;Consumption;cost;Cues;Data;design;Discrimination;Dose;Drug Addiction;Drug Delivery Systems;Drug Exposure;Drug Kinetics;emotional behavior;Ensure;Ethanol Metabolism;Explosion;Exposure to;feasibility testing;Female;Fentanyl;fetal marijuana exposure;Formulation;Funding;Funding Opportunities;Future;Genetic;genetic manipulation;Genome;Goals;Human;Inbreeding;Inhalation;Injections;innovation;insight;Intake;interest;Intraperitoneal Injections;Intravenous;intravenous injection;Laboratories;Long-Term Effects;Lung;male;marijuana legalization;marijuana use;marijuana user;Measures;Methods;Modeling;Monitor;Motivation;mouse model;Mouse Strains;multidisciplinary;Mus;National Institute of Drug Abuse;Nicotine;novel;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physiological;Plants;Plasma;Population;pre-clinical;Pre-Clinical Model;Preparation;Property;Rattus;Recreation;Regimen;Reinforcement Schedule;Reproduction;Research Personnel;response;Rewards;Rodent;Rodent Model;Route;Self Administration;sex;Standardization;Study models;synthetic cannabinoid;Testing;Tetrahydrocannabinol;THC concentration;tool;Validation;vapor;vaporization

PROJECT_TITLE: Pharmacokinetic and motivational properties of vaporized cannabis in mice


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PUBLIC HEALTH NARRATIVE African American/Black (hereafter referred to as Black) adults with HIV/AIDS who smoke constitute a disparities group for poorer smoking cessation outcomes, mental health outcomes, and HIV disease outcomes. Such disparities experienced by this group are, in part, a consequence of the intersection of multiple structural and systemic societal prejudices resulting from HIV status (e.g., HIV stigma) and minority racial status (e.g., racial discrimination) that theoretically engenders increased exposure to interoceptive-stress symptoms (e.g., anxiety, stress, bodily sensations), which is associated with smoking as a means of acute emotion regulation (i.e., coping). To help address this public health issue, our team developed a culturally adapted, highly accessible, and integrated smartphone application that aims to increase smoking cessation, promote mental well-being, and improve HIV outcomes among Black adults with HIV/AIDS who smoke, which we now seek to test in a large-scale, nationwide trial.

PI_NAMEs: BUSINELLE, MICHAEL S.;GAREY, LORRA  (contact)

PROJECT_TERMS: Acute;Address;Adherence;Adult;Affective;African American;Aging;Anti-Anxiety Agents;Anti-Retroviral Agents;Anxiety;anxiety sensitivity;anxiety symptoms;Attenuated;barrier to care;Behavioral;behavioral health intervention;Biochemical;Black Populations;Black race;bodily sensation;Caring;Cellular Phone;Chronic Disease;cigarette smoke;cigarette smoking;Clinical;Collaborations;community clinic;comparison group;Complex;contextual factors;Control Groups;coping;Dangerousness;Data;depressive symptoms;Diagnostic;Discrimination;Disease;Disease Management;Disease Outcome;Disparity;Disparity population;Dissemination and Implementation;dissemination trial;Distress;Ecological momentary assessment;Education;effectiveness/implementation trial;emotion regulation;Emotional;Enrollment;Ensure;Esthesia;Ethnic Origin;Expectancy;experience;Exposure to;follow up assessment;Foundations;General Population;Goals;Health;health care availability;health care quality;health disparity;health disparity populations;health inequalities;HIV;HIV diagnosis;HIV disparities;HIV/AIDS;implementation trial;improved;information gathering;Intervention;intervention effect;Interview;Low income;member;Mental Depression;Mental Health;Methodology;Methods;mHealth;mhealth interventions;Mission;Modeling;Moods;Morbidity - disease rate;mortality;National Cancer Institute;nicotine replacement;novel strategies;Outcome;Participant;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Play;Population;Prejudice;primary endpoint;primary outcome;Process;programs;psychological distress;Public Health;Quality of life;Race;racial discrimination;racial minority;racial minority status;racism;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Reporting;Research;Resources;Risk;Risk Factors;Role;Rural;rural dwellers;Sampling;secondary endpoint;secondary outcome;side effect;smartphone application;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;social health determinants;social stigma;Stress;stress symptom;stressor;success;Target Populations;Testing;Therapeutic;treatment effect;United States National Institutes of Health;Urban Community;Visit;Well in self;Work

PROJECT_TITLE: A National Test of a Culturally Tailored mHealth Integrated Smoking Cessation and Mental Health Intervention for Black Adults with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE This application requests partial funding for the 2024 Pittsburgh International Lung Conference “From Smog to Social Equity: How the Exposome Shapes Our Respiratory Health.” Studying the exposome requires collaboration among diverse fields such as environmental epidemiology, toxicology, and basic science and represents both a timely and suitable topic for a multi-disciplinary conference on lung disease. The 2024 Pittsburgh International Lung Conference will provide a platform for investigators from various disciplines related to the exposome to share ideas, showcase technological innovations, and build collaborations.

PI_NAMEs: BON, JESSICA ;CHANDRA, DIVAY  (contact);WENZEL, SALLY E

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Affect;Aging;ambient air pollution;Asthma;Award;Basic Science;Behavior;Biological;career;Chronic Obstructive Pulmonary Disease;climate change;Clinical;clinical translation;Collaborations;collaborative environment;college;Colorado;Communities;design;Diet;Discipline;Disparity;Doctor of Philosophy;early-career faculty;Electronic cigarette;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Equity;Family;Funding;health equity promotion;Host Defense;Individual;Indoor Air Pollution;insight;Institution;International;Intervention;Ireland;life span;Low income;Lung;Lung Diseases;Malignant neoplasm of lung;Measures;Medical;Medicine;meetings;Metabolism;microbiome;Minority;multidisciplinary;Nursery Schools;Participant;Pathogenesis;Population;Postdoctoral Fellow;posters;precision medicine;Process;professor;programs;Provider;Public Health Schools;Pulmonary Fibrosis;Pulmonology;Request for Applications;Research Personnel;respiratory health;response;Scientific Advances and Accomplishments;Scientist;Shapes;Smog;Smoking;social;social health determinants;Students;Surgeon;symposium;technological innovation;Toxicology;Travel;Universities;Vulnerable Populations;Woman

PROJECT_TITLE: 2024 Pittsburgh International Lung Conference: From Smog to Social Equity: How the Exposome Shapes Our Respiratory Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE We developed and characterized a mouse model with a specific mutation in the long noncoding RNA Xist to study the functional consequences of impaired gene silencing by X-chromosome inactivation in vivo, and thereby established our premise that X-linked gene expression dosage controls formation of the junctional zone, the interface between the fetal and maternal tissue in the placenta. In this proposal, we follow up on these exciting findings by defining mechanisms underlying junctional zone dysplasia induced by altered X chromosome expression. We anticipate that insights gained from these studies will provide a better understanding of female- specific developmental disorders and suggest novel approaches to predict and treat placental dysplasias which often occur in human pregnancies.

PI_NAMEs: PLATH, KATHRIN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Affect;Alleles;Arteries;autosome;blastocyst;Blood Vessels;cell type;Cells;Chromatin;Compensation;Complex;Data;Defect;Development;developmental disease;Disease;DNA mapping;DNA Methylation;dosage;Dosage Compensation (Genetics);Dysplasia;early onset;Embryo;embryo cell;embryo tissue;Embryonic Development;Ensure;Epiblast;Epigenetic Process;experimental study;Female;fetal;Fetal Development;Fetus;follow-up;Gene Dosage;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Goals;Growth;Health;Heterochromatin;Histology;Human;Hybrid Cells;Hybrids;Impairment;implantation;imprint;In Vitro;in vivo;Inherited;insight;Invaded;Link;Maintenance;mortality;mouse development;mouse model;Mus;Mutation;novel strategies;Nutrient;Phenotype;Placenta;placental mammal;Placentation;Polycomb;Pre-Eclampsia;Pregnancy;Proteins;recruit;Regulation;Repression;Resolution;Role;single-cell RNA sequencing;somatic cell nuclear transfer;Testing;timeline;Tissues;transmission process;trophoblast;Untranslated RNA;Up-Regulation;Uterus;Work;X Chromosome;X Inactivation

PROJECT_TITLE: X chromosome dosage compensation and the regulation of the feto-maternal interface

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: NARRATIVE The proposed application is relevant to public health in that the annual meeting of the Society for Leukocyte Biology will bring established scientists and trainees together in seeking a better understanding of diseases that are caused by excessive or poorly regulated inflammation. The 57th meeting is committed to cultivating a diverse, equitable and inclusive scientific community, and to forging an international partnership between scientists in academia, industry and government in the pursuit of translating research into new medicines for clinical use.

PI_NAMEs: LEFORT, CRAIG THOMAS (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Academia;Acute Disease;adaptive immunity;Address;Autoimmunity;Award;Awareness;Basic Science;Biology;career;Career Choice;career development;career networking;cell type;Chronic Disease;Clinic;Clinical;Clinical Research;Coffee;Communicable Diseases;Communities;Data;design;Development;Disease;Disparity population;diversity and inclusion;Doctor of Philosophy;Educational workshop;Equilibrium;Equity;equity, diversity, and inclusion;Ethnic Origin;Event;experience;forging;Fostering;Functional disorder;Funding;Gender;Geography;Goals;Government;Health;Host Defense;human disease;Hypersensitivity;Immune response;Immune system;Immunity;immunodeficiency;Industry;Inflammation;Information Dissemination;innovation;interest;international partnership;Kentucky;Leukocytes;Mediating;medical schools;Medicine;meetings;Mentors;Michigan;Natural Immunity;next generation;novel therapeutic intervention;Oral;pathogen;posters;programs;Public Health;Race;Research;Research Personnel;Role;Scientific Societies;Scientist;Seminal;Societies;success;symposium;Tissues;Translating;Translations;Travel;tumor immunology;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: 57th Annual Meeting of the Society for Leukocyte Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE This diversity supplement will support the career goals of Dr. Joshuaa Allison-Burbank, a speech language pathologist researching quality of care for American Indian and Alaska Native (AI/AN) children with Communication Disorders. Using Individuals with Disabilities Education Act Part C early intervention (EI) service use data for AI/AN children in 6 states, Dr. Allison-Burbank's study will assess family, program, and community correlates of structural racism and discrimination at each step of the EI care system. An explanatory concurrent design with semi-structured interviews of AI/AN families and EI providers will be employed to explain and interpret the quantitative data findings; results will be used to determine strategies for improving EI service delivery to AI/AN children with CDs.

PI_NAMEs: CYCYK, LAUREN M.;ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Advocacy;Affect;Age;Alaska Native;American Indians;Arizona;Attitude;autism spectrum disorder;Belief;care systems;career;caregiver interventions;Caring;Characteristics;Child;Child Health;Child Support;Childhood;Communication;Communication impairment;Communities;cost;Data;Data Aggregation;design;Development;disability;Discrimination;Disparity;Dose;early childhood;early experience;Early identification;Early Intervention;Emotional;empowerment;Equity;Ethnic Population;Evaluation;experience;Family;Family health status;Florida;Fostering;Frequencies;Funding;Geographic Factor;Geography;Goals;Health;health inequalities;hearing impairment;Household;improved;Incidence;Indiana;Individuals with Disabilities Education Act;Inequity;Infant;Intervention;intervention program;Interview;Language;Language Development;Language Disorders;Link;marginalized community;Mediator;member;Mental Health;Methods;Minnesota;native youth;Navajo;Oregon;Outcome;parent project;Pathologist;Personal Satisfaction;Policies;programs;Provider;provider intervention;public health priorities;Pueblo Race;Quality of Care;racial population;racism;Reporting;Research;Research Methodology;Resources;Scientist;Self Efficacy;service delivery;service intervention;Services;skills;social;social culture;sociocultural determinant;sociodemographic factors;Source;Special Education;Speech;Speech Disorders;structural determinants;Structural Racism;Structure;System;Toddler;Trauma;tribal lands;US State

PROJECT_TITLE: Addressing Structural Disparities for Children with Early Communication Disorders (ASCEND)– Diversity Supplement


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE Functional electrical stimulation (FES) is a non-invasive and clinically-feasible technology that uses electrical stimulation to replace or enhance the function of weak or paralyzed muscles. This project will develop and test a new engineering technique to automatically control intensity delivered by FES systems by using new sensing technology (portable ultrasound) to track muscle performance and a new type of automatic controller (data- driven mathematical model that predicts fatigue). By conducting the first evaluation of this novel FES control system in stroke survivors who have footdrop, this work will take an important step toward the long-term goal of using FES to maximize walking function and reduce disability in people with stroke and other nervous system disorders.

PI_NAMEs: KESAR, TRISHA  (contact);SHARMA, NITIN

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Ankle;Behavior;Central Nervous System;Clinical;clinical development;Collaborations;Compensation;correctional system;Data;Data Engineering;data-driven model;design;Development;disability;Electric Stimulation;Engineering;Evaluation;experience;fall risk;Fatigue;Feedback;Foot-drop;functional electrical stimulation;Future;gain of function;Gait;Gait speed;Goals;grasp;high reward;high risk;Implant;improved;improved mobility;innovation;inter-institutional;kinematics;limb movement;mathematical model;Measures;Mobility decline;Modeling;Motion;Muscle;Muscle Fatigue;Muscle function;Nervous System Disorder;Neuronal Plasticity;neuropathology;neuroprosthesis;neurotransmission;novel;Paralysed;Paresis;Performance;Persons;Phase;portability;post stroke;predictive modeling;Reaction;rehabilitation technology;Research;research clinical testing;Resistance;response;safety and feasibility;Scientist;sensor technology;Signal Transduction;Spinal cord injury;Stroke;stroke hemiparesis;stroke survivor;System;Task Performances;Techniques;Technology;Testing;Therapeutic Effect;Time;treadmill;ultrasound;Walking;Work

PROJECT_TITLE: Innovative closed-loop functional electrical stimulation control system for augmenting post-stroke gait

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-G (05)]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: Factors provided to the egg by the mother drive development of the fertilized egg and early embryo, however, little is known about this maternal regulation in vertebrates. This study will identify a new factor that acts in regulating the cytoskeleton, giving competency to the vertebrate egg to proceed in embryonic development and has direct relevance to human reproductive success and female fertility.

PI_NAMEs: MULLINS, MARY C. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Actins;Alleles;Animals;Candidate Disease Gene;Cell Cycle;Cell membrane;Cell Size;Cells;Centrosome;chromosomal location;Competence;CRISPR/Cas technology;Cytoskeleton;Defect;Development;DNA;egg;Embryo;Embryonic Development;Ensure;Etiology;Event;female fertility;Fertility;Fertilization;fluorescence imaging;Future;gene function;Generations;Genes;Genome;genome sequencing;Hand;Haploidy;Human;Image;Induced Mutation;infertility treatment;Mammals;Measures;Meiosis;Metaphase;Microtubule-Organizing Center;Microtubules;Mitotic spindle;Molecular;Mothers;Mus;mutant;Names;Nature;novel;Oocytes;Oogenesis;Play;Ploidies;Process;Proteins;Proteome;Regulation;Reporter;reproductive success;Role;Siblings;Somatic Cell;spatiotemporal;Structure;Study models;Testing;Time;vertebrate embryos;Vertebrates;Vesicle;volcano;whole genome;Woman;Zebrafish;zygote

PROJECT_TITLE: Maternal regulation of microtubules in egg developmental competency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-M (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Borderline Personality Disorder (BPD) is a complex mental disorder associated with aggressive, suicidal, and self-injurious behaviors that often require intensive long-term treatment, resulting in significant treatment costs. Although BPD is associated with impaired decision-making, particularly in social and emotional contexts, little is known about the underlying decision processes and corresponding neural circuits, undermining progress in psychosocial and biological treatments. This supplement requests funds to complete data collection for the parent grant, which seeks to identify neurocomputational markers of impaired decision-making in young adults with BPD symptoms using functional neuroimaging, validated decision paradigms, and computational models based on Bayesian decision theory.

PI_NAMEs: HALLQUIST, MICHAEL NELSON (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: adaptive learning;Adolescence;Adult;Affect;Affective;Age;age related;age related changes;Aggressive behavior;Amygdaloid structure;Anger;Bayesian Method;Behavior;Behavioral;Biological Response Modifier Therapy;biomarker identification;Borderline Personality Disorder;Case/Control Studies;Cell Nucleus;Clinical;Cognitive;cognitive neuroscience;comparison control;Complex;Computer Models;Control Groups;Corpus striatum structure;Cues;Data;Data Collection;Decision Making;Decision Theory;Development;Diagnosis;emerging adult;Emotional;Emotions;Enrollment;Event;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Funding;General Population;Goals;Impairment;improved;Impulsivity;Individual;Informal Social Control;intimate behavior;Learning;Link;maladaptive behavior;Mental disorders;Modeling;Motivation;National Institute of Mental Health;neural;neural circuit;neurodevelopment;neuroimaging;Neurosciences;Neurosciences Research;Nucleus Accumbens;Outcome;parent grant;Participant;Pathway interactions;Personality;Phylogenetic Analysis;Prefrontal Cortex;Prevalence;Process;Psychiatry;Psychological reinforcement;psychosocial;Reaction;recruit;Regulation;Research;Resistance;Resolution;response;Rest;Role;Self-Injurious Behavior;Severities;sex;Signal Transduction;social;Social Anxiety Disorder;social influence;Specificity;Stimulus;Strategic Planning;suicidal;Suicide attempt;Symptoms;System;Testing;Treatment Cost;Work;young adult

PROJECT_TITLE: Neurocomputational mechanisms of impaired social decision-making in borderline personality


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Rare Diseases;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: 8. Project Narrative In Africa, meningitis ranks second among HIV/AIDS defining illnesses, contributing approximately 15- 20% of AIDS-related mortality. Historically, Cryptococcus and TB were the two most common causes of meningitis in Africa. However, with the widespread rollout of HIV therapy, the epidemiological landscape is likely shifting. This project aims to define the current epidemiology, validate novel diagnostic tests, and carry out a mechanistic proof-of-concept trial for a new antifungal drug to treat fungal meningitis.

PI_NAMEs: BOULWARE, DAVID R (contact);MEYA, DAVID BISAGAYA

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Adult;Africa;Age;Algorithms;Amphotericin;Amphotericin B;anti-fungal agents;Antigens;antiretroviral therapy;Azoles;Biological;Biological Assay;Central Nervous System Infections;Cessation of life;Clinical;Clinical Research;Clinical Trials;Consolidation Therapy;Coupled;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic assay;Diagnostic tests;diagnostic value;Dose;Enrollment;Epidemiology;Etiology;experience;Failure;Fluconazole;Fluconazole resistance;Flucytosine;follow-up;Fungal Meningitis;genetic signature;Goals;HIV;HIV anti-retroviral;HIV Infections;HIV Seropositivity;HIV therapy;HIV/AIDS;Immune response;immunodeficiency;improved;In Vitro;in vitro activity;in vivo;Incidence;Laboratories;lateral flow assay;Liposomes;Manuscripts;Meningeal Tuberculosis;Meningitis;molecular diagnostics;Morbidity - disease rate;mortality;Neurocognitive;Neurologic;Neurological disability;Neurological outcome;novel diagnostics;Oral;Outcome;Performance;Persons;Phase;point of care;Population;Productivity;Prophylactic treatment;prospective;Prospective cohort;Prospective, cohort study;Publishing;Randomized;Relapse;Research;standard of care;Sterilization;survival prediction;Testing;Tetrazoles;Therapeutic;Tuberculosis;Uganda;Whole Blood;Yeasts

PROJECT_TITLE: Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Major Depressive Disorder;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Economic choice – a behavior specifically disrupted in disorders such as frontotemporal dementia and major depression – entails the computation and comparison of subjective values. Previous work indicates that these operations rely on the orbitofrontal cortex (OFC). This project will examine how neuronal activity in OFC adapts to different behavioral conditions, for example when multiple options are available for choice, or when the motivational state of the subject changes. 1

PI_NAMEs: PADOA-SCHIOPPA, CAMILLO  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TITLE: THE ROLE OF PREFRONTAL REGIONS IN ECONOMIC CHOICE AND CHOICE-GUIDED BEHAVIOR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]