ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Non-alcoholic fatty liver disease (NAFLD) is a new condition that has become the most common chronic liver disease in the world and a main cause of liver cirrhosis, liver failure and liver cancer . Obesity and diabetes, conditions that are very common among Veterans are the main risk factors for NAFLD. T herefore, the burden of NAFLD and its complications among Veterans is substantial. However, most VA patients with NAFLD are undiagnosed and untreated, and their care is not consistent with practice guidelines. Our NAFLD Clinical Care Pathway (NCCP) intervention seeks to close this major gap in the care of Veterans by automatically id entifying patients at risk of NAFLD, calculating their risk scores of having severe NAFLD, and educating the primary care providers on the diagnosis and treatment of NAFLD. This clinical trial will test the benefit of this NCCP intervention against usual care in increasing the rates of NAFLD diagnosis as well as referral to and enrollment in appropriate treatment. The study will also identify barriers and promotors of future NCCP implementation.

PI_NAMEs: EL-SERAG, HASHEM B (contact);GODWIN, KYLER M.

PROJECT_TERMS: acceptability and feasibility;accurate diagnosis;Address;Adopted;Adoption;Adult;Affect;Alcohols;Algorithms;Benign;Biological Markers;Body Weight decreased;Cardiovascular Diseases;care outcomes;Caring;Characteristics;chronic liver disease;Cirrhosis;Clinical;clinical care;Clinical Trials;Cluster randomized trial;compare effectiveness;comparison intervention;Consensus;Control Groups;Data;design;Diabetes Mellitus;Diagnosis;Disease;disease diagnosis;Disease Management;Disease stratification;disorder risk;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Electronics;Eligibility Determination;Enrollment;Ensure;Equilibrium;Equity;Evaluation;evidence base;Face;Fatty Liver;Feedback;Fibrosis;Focus Groups;formative assessment;Foundations;Future;future implementation;Guidelines;Health Services Accessibility;Hepatology;high risk;implementation determinants;Improve Access;improved;Incidence;Individual;innovation;integrated care;International;Intervention;intervention effect;Interview;Life Style;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver transplantation;Malignant neoplasm of liver;Medical center;medical specialties;member;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multi-component intervention;multiple chronic conditions;non-alcoholic fatty liver disease;Obesity;Outcome;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Performance;personalized care;Persons;Pharmaceutical Preparations;Physical activity;Practice Guidelines;Prevalence;Prevention;Primary carcinoma of the liver cells;Primary Care;primary care clinic;primary care patient;primary care practice;primary care provider;primary care setting;primary outcome;Process;promoter;prospective test;Provider;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Risk;Risk Factors;risk stratification;screening;secondary outcome;Severities;Severity of illness;Steatohepatitis;Structure;Techniques;Testing;treatment as usual;treatment center;United States;United States Department of Veterans Affairs;Veterans;weight loss program;Work;working group

PROJECT_TITLE: Testing the Effectiveness of NAFLD Clinical Care Pathway in VA Primary Care

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Non-pharmacological, accessible chronic pain treatment options are urgently needed for Veterans. This proposed project will provide at-home access to an evidence-based chronic pain treatment using and online acceptance and commitment therapy-based intervention for improving pain-related functioning and quality of life. According to the 2022-2028 Strategic Plan, the VA has also committed to translating and leveraging innovation to inform the development of pain management treatments. Thus, our project will fill a substantial gap in VHA pain services by evaluating a remotely-delivered chronic pain treatment, Veteran Acceptance and Commitment Therapy for Chronic Pain (VACT-CP) using a fully-powered, multisite efficacy trial (total n=200).

PI_NAMEs: REILLY, ERIN  (contact)

PROJECT_TERMS: active control;Address;Adult;Affect;Aftercare;Anxiety;arm;Award;behavior change;Behavior Therapy;Buffers;Caring;Chronic;chronic pain;chronic pain management;Cladribine;Clinic;comorbidity;Data;Development;Diagnosis;Diagnostic;digital intervention;Distress;Effectiveness;efficacious treatment;efficacy evaluation;efficacy trial;Evaluation;evidence base;Evidence based intervention;Facial Pain;Family member;Family Relationship;flexibility;follow-up;functional improvement;functional outcomes;Funding;General Population;Health;Heart Diseases;Home;Hospitals;Impairment;improved;innovation;Intervention;Life;Mediating;medical specialties;Mental Depression;Mental Health;mindfulness;mortality;online intervention;opioid mortality;Outcome;Pain;Pain Clinics;Pain interference;Pain management;pain model;pain self-management;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;Primary Care;primary outcome;Process;psychologic;Quality of life;Randomized;Rehabilitation therapy;remote delivery;Reporting;Research;research and development;satisfaction;Schedule;Schools;screening;Self Management;self-management program;Services;Severities;Site;Social support;Strategic Planning;Symptoms;Technology;Therapeutic;Therapeutic Intervention;Time;Training;Translating;Transportation;Treatment Step;trial comparing;usability;user centered design;Veterans;virtual;virtual coach;Work

PROJECT_TITLE: Assessing the Efficacy of an Acceptance-Based Digital Intervention to Improve Functioning for Veterans with Chronic Pain

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The ability to produce right words while speaking can become impaired in certain neurological conditions, or when brain areas that are critical for word production are disrupted during surgical treatment for medication- resistant epilepsy or brain tumors. Tests and techniques to diagnose impairment and to identify and protect critical language sites in the brain have been developed in English; however, we are currently unable to provide this same level of care to the numerous Spanish speakers who require neurological diagnosis and brain surgery. This project will develop and validate these language measures and techniques in Spanish to bring the level of clinical care on par with that provided for native English speakers.

PI_NAMEs: HAMBERGER, MARLA J (contact);SCHEVON, CATHERINE A

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: accurate diagnosis;Address;Affect;Age;Area;Auditory;bilingualism;Brain;Brain Mapping;Brain Neoplasms;brain surgery;Caring;Cerebral Dominance;Classification;Clinical;clinical care;clinical predictors;clinically relevant;cost;curative treatments;Data Set;Development;Diagnosis;Diagnostic;Disparity;Electric Stimulation;Epilepsy;ethnic disparity;Evaluation;Excision;Failure;frontal lobe;Functional disorder;Goals;Handedness;health care disparity;high risk;Impairment;improved;individual patient;Intractable Epilepsy;Knowledge;Language;Language Tests;Left;Lesion;Linguistics;Location;Maps;Measures;Modality;Names;Nervous System Disorder;Neurobehavioral Manifestations;neuroimaging;Neurologic;Neuropsychological Tests;Neurosciences;novel;Occupational;Operative Surgical Procedures;Patients;Performance;Pharmaceutical Preparations;Play;Population;Postoperative Period;Predictive Factor;Predictive Value;preservation;Procedures;Process;Production;racial disparity;Research;Resistance;Risk;Role;Seizures;Site;social;Spanish;Spanish/English;Standardization;Stimulus;success;Surgical margins;Symptoms;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Testing;tool;Translating;verbal;Visual;Vocabulary;Work

PROJECT_TITLE: Development of Culturally Appropriate Spanish Language Tests for Neuropsychological Assessment and Brain Mapping

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: OTHERS

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Nonsuicidal self-injury (NSSI) is the intentional destruction of one’s body tissue without suicidal intent and includes methods such as cutting, burning, or scratching oneself. Although NSSI is different from behaviors that have suicidal intent, NSSI is a risk factor for future suicide attempts. Individuals report engaging in NSSI for a variety of reasons such as emotion regulation (e.g., to feel less angry) or for interpersonal reasons (e.g., to end an argument). NSSI is common among Veterans but there are few effective treatments. The proposed study would develop a psychotherapy treatment specifically for Veterans with the aim of reducing NSSI. This treatment will also include mobile technology to allow for tracking of NSSI behaviors outside of therapy sessions. Knowledge generated by this research could be used to improve treatment options for Veterans engaging in NSSI and prevent Veteran suicide.

PI_NAMEs: HALVERSON, TATE F (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Anger;arm;Behavior;Borderline Personality Disorder;brief intervention;career;Clinical;clinical care;clinical center;Clinical Investigator;Clinical Trials;Clinical Trials Design;cohort;Conduct Clinical Trials;contextual factors;Data;design;Development;Distress;Ecological momentary assessment;Education;effective therapy;efficacy testing;emotion regulation;evidence base;experience;follow-up;functional improvement;Funding;Future;General Population;Goals;Guidelines;High Prevalence;high risk behavior;Impairment;improved;in vivo;Individual;individualized medicine;Intervention;Intervention Trial;Investigator-Initiated Research;Knowledge;Manuals;Measures;men;Mental disorders;Mental Health Services;Mentorship;Methodology;Methods;mobile computing;Modeling;Modification;multilevel analysis;non-suicidal self injury;Postdoctoral Fellow;Prevalence;prevent;primary outcome;programs;Protocols documentation;psychosocial;Psychotherapy;Quality of Care;Randomized;Randomized, Controlled Trials;Recovery;rehabilitation research;Reporting;Research;Research Activity;research and development;Research Personnel;Risk;Risk Factors;Safety;Self Direction;Self-Injurious Behavior;skill acquisition;Statistical Models;suicidal;suicidal behavior;Suicide;Suicide attempt;Symptoms;Therapeutic;therapy development;Tissues;Training;Training Activity;treatment as usual;Treatment Efficacy;Veterans;Violence;Woman;Women's prevalence

PROJECT_TITLE: A Brief Intervention to Reduce Nonsuicidal Self-Injury and Improve Functioning in Veterans

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: GENOME INFORMATICS  December 6 - 9, 2023 LAY NARRATIVE  The explosion of genomic information in the past decade poses an enormous challenge to computational biologists in how to manage this information and render it meaningful and useful. Without intense discussion of a variety of different approaches to handling this information to ensure that it can be applied across diverse species, systems and scales, the data is in danger of being isolated in virtual silos where it is much less useful. The Cold Spring Harbor Laboratory conference on Genome Informatics will focus on the provision and use of large scale genomic data and annotations. Genomic resources provide the fundamental descriptions of an increasing array of organisms at the molecular level. The goal of the series is to explore both the latest provision of these resources, and perhaps most importantly, their use as engines of biological discovery. This ranges from the storage of data and their associated data models, to the design of effective algorithms to uncover non- obvious aspects of these datasets, to ontologies to concisely describe biological information, and software systems to support curation, visualization, and exploration.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Algorithms;American;Area;Asian;Bioinformatics;Biological;biological systems;Biology;career;Communities;comparative;computer scientist;Data;data modeling;Data Set;Data Storage and Retrieval;database design;design;Development;digital;Discipline;Disease remission;Ensure;Environment;European;Expert Systems;Explosion;Faculty;Family;Fostering;Genome;genome analysis;genome annotation;genome database;Genome engineering;genome resource;genome sciences;genome-wide;genomic data;Genomics;Geography;Goals;graduate student;Hybrids;Image;Industrialization;Informatics;Information Management;Information Systems;interest;International;Joints;Laboratories;lectures;Length of Stay;meetings;member;microbial;Molecular;Molecular Biology;next generation;novel;Ontology;Oral;Organism;Participant;Pathogenesis;peer;Play;Postdoctoral Fellow;posters;Publications;Published Comment;Research;Research Institute;Research Personnel;Resources;Schedule;Science;Scientist;Seasons;Senior Scientist;Series;skills;Software Engineering;software systems;success;symposium;System;tool;Travel;Trust;Underrepresented Minority;virtual;Visualization;Woman;Work

PROJECT_TITLE: CSHL 2023 Genome Informatics Conference

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: This CDA-1 aims to advance the measurement of reintegration difficulty and clarify who is at greatest risk of reintegration difficulty and subsequent suicidal thoughts and behavior. Results from Aim 1 can be used to identify Veterans with life role and community reintegration challenges in research and clinical settings. Results from Aim 2 can be used to inform the development of interventions aimed at promoting positive functional outcomes for transitioning Veterans. Results from Aim 3 can be used to inform suicide prevention efforts for Veterans who are in the process of transitioning out of the military.

PI_NAMEs: GREENE, ASHLEY L. (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Age;Attention;Award;Clinical;Communities;community reintegration;Data;Data Analyses;data repository;Data Set;Development;Discrimination;DSM-V;empowerment;Equation;Evaluation;Event;Face;Factor Analysis;Feeling;Feeling suicidal;Foundations;functional outcomes;Future;Goals;Growth;Healthcare;high risk;Home;improved;Individual;Individual Differences;innovation;insight;interest;Intervention;Investigation;Life;longitudinal design;Longitudinal Studies;Meaning and purpose;Measurement;Measures;Mental Depression;Mentors;Mentorship;Methodology;Military Personnel;Modeling;Outcome;peer;Personality;Personality Disorders;Persons;Post-Traumatic Stress Disorders;prevent;Prevention Research;Process;Program Evaluation;programs;Property;Psychology;Psychometrics;Psychopathology;Questionnaires;Recommendation;Rehabilitation therapy;repository;Research;response;Risk;Role;Sampling;service member;Services;Societies;Statistical Data Interpretation;stressor;Structure;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;System;theories;Therapeutic Intervention;therapy development;Thinking;Time;Training;Veterans;Work

PROJECT_TITLE: Measurement and Prediction of Reintegration Difficulty and Suicide Risk During the Military to Civilian Transition Period


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Age Related Macular Degeneration (AMD) is the leading cause of vision loss among Veterans aged 50 years and older. AMD also adversely affects mortality, physical and cognitive functioning, and activities of daily living. To address the lack of cures or accessible treatments, based on significant preliminary data, we propose to test the impact of a proven exercise intervention, a 6-month, synchronous, online group stationary bicycling (spinning) regimen, on visual, cognitive, and physical outcomes in Veterans with AMD. This an accessible, low-cost intervention that can be easily scalable to other VA centers to improve visual and functional capacity for Veterans with AMD who are at high risk for comorbidities.

PI_NAMEs: BOATRIGHT, JEFFREY H;NOCERA, JOE ROBERT (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Aerobic Exercise;Affect;Age;age related changes;Age related macular degeneration;aged;Aging;Angiography;Animals;Area;Bicycling;Blindness;Blood Vessels;Brain-Derived Neurotrophic Factor;burden of illness;clinically significant;Cognitive;cognitive function;comorbidity;Contrast Sensitivity;Control Groups;cytokine;Dark Adaptation;Darkness;Data;digital;disability;Equilibrium;executive function;Exercise;exercise intervention;exercise training;Family;functional improvement;Health;Health Services Accessibility;Healthcare Systems;high risk;Home;human subject;improved;improved mobility;indexing;Intervention;intervention cost;Legal Blindness;legally blind;luminance;MicroRNAs;military veteran;Modernization;Morphology;mortality;mouse model;multi-site trial;neuroprotection;Neuropsychology;Neurotrophic Tyrosine Kinase Receptor Type 2;new technology;older adult;Optical Coherence Tomography;Outcome;Outcome Assessment;pandemic disease;patient population;Patient Self-Report;Performance;Personal Satisfaction;Physical Function;pilot trial;preservation;Prevalence;primary outcome;Procedures;programs;Quality of life;Questionnaires;Randomized, Controlled Trials;Receptor Activation;Regimen;Rehabilitation therapy;remote delivery;Retina;Retinal Degeneration;retinal neuron;Rodent Model;secondary outcome;Serum;Social isolation;Stretching;Structure;Study Subject;Technology;telehealth;Testing;Time;Veterans;Videoconferencing;virtual;virtual healthcare;Vision;Visual;Visual Acuity;Visual impairment;Work

PROJECT_TITLE: The Active AMD Study to Improve Function in Veterans with Age Related Macular Degeneration

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Symptoms of moral injury (guilt, shame, self-isolation) are common in Veterans being treated for posttraumatic stress disorder (PTSD) or substance use disorder (SUD) and current treatments do not always improve these symptoms. Moral injury is also considered a risk factor for suicidal thoughts and behaviors. Moral injury symptoms overlap with symptoms of PTSD but they are not the same problem. Mental Health Clinician / Chaplain Collaboration (MC3) was developed with Veteran, mental health clinician, and chaplain input to address moral injury symptoms. MC3 uses VA chaplains to facilitate forgiveness and community reintegration with a community group of the Veterans’ choosing. The proposed study will examine the feasibility and acceptability of the MC3 intervention from the perspectives of Veterans, mental health clinicians, chaplains, and members of community groups. Results from this study will be used to inform a larger future study. To our knowledge this is the only moral injury intervention that directly supports community reintegration.

PI_NAMEs: PYNE, JEFFREY M. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;arm;attentional control;Audience Research;Behavioral;Belief;Biological;care coordination;Caring;Chaplain;Characteristics;Child;Clergy;Clinic;Clinical;Collaborations;combat zone;common symptom;Communities;Community Mental Health Services;community organizations;community reintegration;comorbidity;Data;Diagnosis;diagnostic criteria;Distress;Electronic Health Record;Eligibility Determination;Event;evidence base;expectation;experience;Exposure to;Family;Feeling suicidal;forgiveness;formative assessment;Future;Goals;Guilt;Health Status;Healthcare Systems;improved;innovation;Interdisciplinary Study;Intervention;Knowledge;Learning;learning community;Legal;long term recovery;medical specialties;member;Mental Health;Mental Health Services;Methodology;Methods;military operation;Military Personnel;military service;military veteran;Moral injury;Morals;Outcome Measure;Patients;Pilot Projects;Population;Positioning Attribute;post implementation;Post-Traumatic Stress Disorders;prevent;Prevention;primary outcome;Procedures;Process;Professional counselor;psychologic;Psychotherapy;Publishing;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;Religion;Reporting;Research Design;Research Methodology;Research Priority;Residual state;Resources;Risk Factors;Role;Services;Shame;Site;Social Impacts;Social isolation;Spiritual care;Spirituality;stem;Substance Use Disorder;substance use treatment;suicidal behavior;suicidal risk;Suicide;Suicide attempt;symptomatic improvement;Symptoms;Time;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Mental Health Clinician/Chaplain Collaboration (MC3): A Pilot Study

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: One in 10 Veterans have an alcohol use disorder. However, few Veterans receive evidenced-based psychosocial interventions or medications to treat alcohol use disorder. Barriers to receiving these treatments include long wait times, stigma, and long distances from treatment facilities. Even fewer Veterans receive psychosocial and medication interventions together, despite clinical practice guidelines recommending both and evidence of better outcomes. Expanding access to these treatments in primary care is a VA priority but delivering psychosocial interventions is difficult in this setting, and medication is often the only option. Smartphone apps that deliver alcohol interventions may improve drinking outcomes and ensure Veterans can receive both treatments in primary care. This study will determine whether medications and an app for alcohol use problems offered to Veterans in primary care results in improved drinking outcomes, compared to Veterans receiving medications only. Study data will inform how to spread the app across the VA nationally.

PI_NAMEs: HAWKINS, ERIC  (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Affect;Age;Alcohol abuse;alcohol abuse therapy;alcohol availability;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol monitoring;alcohol use disorder;Alcohols;arm;Awareness;barrier to care;care systems;Caring;Cellular Phone;Clinic;Clinical;clinical care;Clinical Management;Clinical Pharmacists;Clinical Practice Guideline;Cohort Studies;Combination Medication;Computerized Medical Record;contextual factors;cost;Data;design;Development;Diagnosis;drinking;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Enrollment;Ensure;evidence base;follow-up;Goals;Guidelines;health care settings;Health Services Accessibility;Healthcare;Heavy Drinking;high risk;Hybrids;implementation strategy;Improve Access;improved;Individual;innovation;Intervention;Interview;medical specialties;meetings;Mental Health;Methodology;Minority Groups;mobile application;mobile computing;Morbidity - disease rate;mortality;Motivation;operation;Outcome;Participant;Patient Self-Report;Patients;Pattern;personalized strategies;Pharmaceutical Preparations;pharmacy benefit;Pharmacy facility;Pilot Projects;Practice Guidelines;Primary Care;primary care patient;primary outcome;process evaluation;psychosocial;Quality of Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Risk;satisfaction;scale up;Schedule;secondary outcome;Self Management;Services;Site;smartphone application;social stigma;Specialist;Strategic Planning;Substance Use Disorder;Suicide prevention;support network;Training;United States;United States Department of Veterans Affairs;usability;Veterans;Wait Time;Work

PROJECT_TITLE: Combining a Smartphone App with Medications to Manage Heavy Drinking


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Psychosocial stress can profoundly impact bi-directional communication between the immune system and brain. Here, we propose to study how stress mobilizes the innate immune system to increase blood brain barrier permeability and promote deficits in both social and non-social reward/reinforcement by directly regulating neuronal activity in brain reward regions such as the nucleus accumbens.

PI_NAMEs: RUSSO, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Affect;avoidance behavior;Behavior;Behavioral;Bioinformatics;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Bone Marrow;Brain;brain circuitry;Brain region;brain reward regions;Cell Communication;cell type;Cells;Central Nervous System;Chronic;Chronic stress;Circulation;Communication;Complex;cytokine;Data;Development;Disabling;Dopamine;Endopeptidases;Exhibits;Extracellular Matrix;Extracellular Space;Female;Frequencies;Gene Expression;Genes;Goals;high dimensionality;Human;Immune;immune activation;Immune response;Immune system;Immunologic Factors;Impairment;in vivo;individual response;Infiltration;Inflammatory;Innate Immune System;insight;Leukocytes;Link;male;Matrix Metalloproteinases;Mediating;Mediator;Mental disorders;Molecular;monocyte;Motivation;Mus;Myelogenous;Myeloid Cells;Nervous System Physiology;Neuroimmune;Neuroimmunomodulation;Neurons;neurophysiology;Neutrophil Collagenase;new therapeutic target;novel;Nucleus Accumbens;Outcome;Pathway interactions;Penetration;perceived stress;Peripheral;Phenotype;Physiology;Plasma;Play;Predisposition;prevent;Proliferating;Proteins;Proxy;Psychological reinforcement;Psychosocial Stress;Publishing;receptor;resilience;Rewards;Role;single-cell RNA sequencing;social;Social Behavior;social defeat;Stress;stress disorder;Testing;Tissues;tool;trafficking;Work

PROJECT_TITLE: ROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITY

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Fifteen thousand Veterans are hospitalized with stroke related diagnoses each year. Approximately half are left with permanent and significant disability of their shoulder, arm, and hand, including extreme weakness and abnormal muscle activity. Thus far, rehabilitation therapy has resulted in limited gains. Efforts to use the shoulder often result in unintentional muscle contractions through the rest of the arm making functional use even more challenging, leading to a pattern of disuse. One solution is to support the shoulder and hand with a combination of two exoskeletons to compensate for the weakness and minimize these abnormal muscle contractions. Supporting the shoulder with a wearable device is novel and necessary to regain maximal range of motion and function after stroke. Once realized, it is hoped that the combination of these two wearable devices named, Shoulder-Hand Active-Passive Exoskeleton (SHAPE) can support the Veteran in his or her activities of daily living, encourage the use of their affected arm, and ultimately improve function and quality of life.

PI_NAMEs: KOPKE, JOSEPH VICTOR (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Air;Area;arm;Articular Range of Motion;Chronic;Clinic;Clinical;Compensation;Confusion;cost;Decision Making;design;Development;Device Designs;Device or Instrument Development;Devices;Diagnosis;disability;Doctor of Philosophy;efficacy study;Elbow;Engineering;exoskeleton;exoskeleton device;experience;Feedback;Force of Gravity;Functional impairment;functional improvement;Goals;grasp;Hand;Hand functions;hand rehabilitation;Hospitalization;Hybrids;Impairment;improved;Individual;insight;Institution;Intuition;Knowledge;Left;Lifting;Limb structure;Long term disability;loss of function;Machine Learning;Measures;Mentors;Mentorship;Motion;motor control;Movement;Muscle;Muscle Contraction;Names;Neurologic;Neurosciences;novel;open source;operation;Orthotic Devices;Outcome;Participant;Patients;Pattern;Pattern Recognition;Phase;post stroke;prototype;Quality of life;Rehabilitation therapy;Research;Rest;Robot;Robotics;Role;Scheme;Scientist;Secondary to;Self-Help Devices;Shoulder;standard of care;Stroke;stroke rehabilitation;stroke survivor;success;System;Technology;Tendon structure;Testing;Therapeutic Intervention;Time;Training;Universities;Upper Extremity;usability;Veterans;Veterans Health Administration;wearable device;Weight;Work;Wrist;wrist function

PROJECT_TITLE: Development and initial testing of a shoulder-hand active-passive exoskeleton (SHAPE) to assist individuals with chronic upper-extremity impairments after stroke.

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Childhood and adolescence comprise a vulnerable period for the developing brain, and long-term exposure to early life stress (ELS) causes distinct neurobiological changes that persist throughout the lifespan. The present study uses PET-MR imaging to test an ELS-induced model of anhedonia in major depressive disorder that is driven by threat- and reward-related neuroinflammatory mediators. It is critical to clarify the pathophysiological mechanisms by which ELS confers risk for psychopathology to hasten the development of mechanism- informed interventions to prevent or reduce negative health outcomes.

PI_NAMEs: PHILLIPS, RACHEL DEANNA (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Adolescence;Adult;Age;Amygdaloid structure;Anhedonia;Autopsy;Binding Proteins;Brain;Brain region;Childhood;clinically significant;depressive symptoms;Development;Diagnostic;diagnostic criteria;early life adversity;early life stress;Exposure to;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Gene Expression;Goals;Grant;Health;Human;human imaging;imaging study;Immune;indexing;Individual;Inflammation;Inflammatory;Innate Immune System;Intervention;Knowledge;life span;Link;Major Depressive Disorder;Measures;Mediating;Mediation;Mediator;Mental disorders;Microglia;Modeling;Motivation;National Institute of Mental Health;neural;neural circuit;Neurobiology;neuroinflammation;Outcome;Parents;Pathway interactions;Patients;Peripheral;peripheral blood;Phenotype;pleasure;Positron-Emission Tomography;Prefrontal Cortex;prevent;Process;protein expression;Proteins;Psychopathology;radioligand;Research;reward processing;Rewards;Risk;Severities;Stress;Stressful Event;Symptoms;Testing;Tissues;Ventral Striatum;vigilance;Work

PROJECT_TITLE: Neuroinflammation as a Mechanism Linking Early Life Stress, Altered Functional Connectivity, and Anhedonia in Major Depression


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: As most cellular energy is generated by mitochondria, perhaps it is not surprising that about 1 in 5000 children will develop mitochondrial disease. This proposal focuses on a protein component of mitochondrial membranes, the ADP/ATP carrier, that is indispensable for energy production by mitochondria and which participates in a number of evolutionarily conserved physical interactions that are dependent on a single phospholipid, cardiolipin, only found in mitochondrial membranes. Several mutations in the ADP/ATP carrier cause heart and muscle disease and alterations in the normal metabolism of the phospholipid cardiolipin, which may result in defective ADP/ATP carrier assembly and/or function, have been documented in numerous distinct cardiomyopathies.

PI_NAMEs: CLAYPOOL, STEVEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Adenine Nucleotide Translocase;Binding;Binding Sites;Biochemical;Bioenergetics;Biology;Biophysics;Cardiolipins;Cardiomyopathies;Cardiovascular Diseases;Cause of Death;Cell model;Child;clinically relevant;Co-Immunoprecipitations;Complement;Complex;complex IV;Computer Analysis;crosslink;Dependence;Detergents;dimer;Disease;Electron Transport Complex III;Engineering;Enzymes;Family;Functional impairment;Genes;Goals;Health;Heart Diseases;Human;Individual;inhibitor;insight;Knowledge;Link;Lipids;Mammals;Mediating;Membrane;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial fitness;Mitochondrial Matrix;mitochondrial membrane;Modeling;Molecular;Molecular Conformation;molecular modeling;Multiprotein Complexes;mutant;Mutation;Myopathy;novel;Oxidative Phosphorylation;Pathogenicity;Pediatric Cardiomyopathy;Phospholipid Metabolism;Phospholipids;Positioning Attribute;Production;protein complex;protein function;Protein Isoforms;protein protein interaction;Proteins;Proteomics;rational design;respiratory;Role;Saccharomyces cerevisiae;Series;SLC25A4 gene;SLC25A5 gene;Structure;Testing;thermostability;United States;unnatural amino acids;Yeasts

PROJECT_TITLE: An intimate and multifaceted partnership: cardiolipin and the mitochondrial ADP/ATP carrier


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Eye Disease and Disorders of Vision;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Regenerative Medicine

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARATIVE Decreasing inflammation in the heart after heart attack (myocardial infarction) has shown promise at improving heart function and reducing adverse cardiovascular events in patients with heart failure. While systemic immunomodulation has shown promise to reduce myocardial inflammation and promote tissue healing, the efficacy of this potentially transformative approach remains limited by inefficient delivery to heart, off-target effects, and pleiotropic and sometimes paradoxical responses that prevents application for chronic heart failure. This project will address these shortcomings by utilizing a novel cell therapy platform to (i) enable sustained cell survival and delivery of secretory proteins to the heart, (ii) understand how this changes heart immune populations to promote heart tissue repair, and (iii) translate therapy in a clinically relevant fashion to a large animal model of heart failure.

PI_NAMEs: GHANTA, RAVI K (contact)

PROJECT_TERMS: absorption;Acute myocardial infarction;Affect;Alginates;anakinra;angiogenesis;Animal Model;AP 1903 reagent;Apoptotic;Biodistribution;Biological;Biological Assay;biomaterial compatibility;Biotechnology;capsule;Cardiac;Cardiovascular system;CASP9 gene;Catheters;Cause of Death;cell capsule;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Chronic;Cicatrix;Clinical;clinical translation;clinically relevant;Combined Modality Therapy;Congestive Heart Failure;Contact Inhibition;cytokine;cytokine therapy;Cytometry;design;Dose;Encapsulated;Endothelial Cells;Endothelium;Engineering;Event;Family suidae;Fibroblasts;Fibrosis;Formulation;healing;Heart;Heart failure;heart function;Histology;Human;Hydrogels;Image;Immune;Immune Evasion;Immune response;Immune system;Immunomodulators;immunomodulatory strategy;immunoregulation;Immunosuppression;Implant;implantation;improved;improved outcome;In Situ;in vivo;Individual;Industrialization;Infarction;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;insight;Interleukin-1;Interleukin-10;ischemic cardiomyopathy;Leukocytes;Link;local drug delivery;Macrophage;Magnetic Resonance Imaging;Measures;Modeling;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;nonhuman primate;novel;novel strategies;paracrine;Pathologic;Patients;Pericardial body location;Phenotype;Physiological;Population;porcine model;Pre-Clinical Model;Preclinical Testing;prevent;Proteins;Rattus;Recovery of Function;Regulatory T-Lymphocyte;repaired;response;retina implantation;Route;Safety;secretory protein;single-cell RNA sequencing;small molecule;Structure of retinal pigment epithelium;subcutaneous;success;System;Testing;Therapeutic;Time;tissue repair;Tissues;Titrations;Toxic effect;Translating;Translations;Ventricular Function;Ventricular Remodeling;Work

PROJECT_TITLE: Cell Based Immunomodulation to Promote Post-Infarct Myocardial Repair

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Despite being a powerful approach for investigating mechanisms of human disease, mosaic analysis is difficult to apply to a large number of existing genetic resources in Drosophila with available methods. This project will develop tools for a new mosaic technique to enable mosaic analysis with existing genetic resources for systematic gene-function analysis, genome-wide genetic screens, and tissue- specific analysis of natural variants. Mosaic screens will be conducted in neurons and epithelial cells using this technique to search for genomic deletions that harbor genes important for diseases in neuronal and epithelial tissues.

PI_NAMEs: HAN, CHUN  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Advisory Committees;Animals;arm;Biology;cell type;Cells;Cellular biology;Centromere;Chromosome Arm;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;CRISPR/Cas technology;Crossover Design;Defect;Development;Developmental Biology;Disease;disease mechanisms study;Drosophila genus;Drosophila melanogaster;Effectiveness;Epithelial Cells;Epithelium;Essential Genes;experimental study;Feedback;flexibility;Future;gene function;Gene Transfer Techniques;Genes;Genetic;Genetic Crossing Over;genetic manipulation;Genetic Recombination;genetic resource;Genetic Screening;genome-wide;Germ Lines;Goals;Guide RNA;Health;Heritability;Heterozygote;human disease;innovation;interest;Label;Libraries;marker transgenes;Methods;model organism;Modification;Molecular;Morphogenesis;Morphology;mosaic;mosaic analysis;mutant;Mutation;Nerve Degeneration;Nervous System;neurodevelopment;Neurons;novel;novel strategies;Organism;Plasmids;Play;Population;precursor cell;prevent;Reagent;repository;Research;Resolution;Resources;Screening Result;Sequence Deletion;Series;Site;somatosensory;System;Techniques;Tissue Microarray;Tissues;tool;Transgenes;Variant;Visualization;whole genome

PROJECT_TITLE: MAGIC tools for genome-wide mosaic analysis with existing Drosophila resources

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative The aim of this application is to understand the molecular mechanism of the piRNA pathway, which represses genomic parasites known as transposable elements and controls host gene expression. Transposon repression is critical in germ cells, where the failure of piRNA-mediated repression leads to sterility and has also been linked to aging and cancer. Investigation of the molecular mechanism of the piRNA pathway is of great importance to our understanding of control of transposons and host genes in health and disease and will provide the basis for directing piRNAs to new targets for use them in research and therapy.

PI_NAMEs: ARAVIN, ALEXEI A. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adopted;Affect;Aging;Animals;Anti-viral Response;Arginine;Binding;Biogenesis;Biomedical Research;Cell Line;Cell membrane;Cell Nucleus;Chromatin;Complex;Cytoplasm;Deposition;Development;Disease;DNA Transposable Elements;Drosophila genus;egg;Embryonic Development;Environment;Eukaryotic Cell;Failure;Fertility;fly;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genome Stability;genomic locus;Genomic Segment;Genomics;Germ Cells;Germ Lines;Health;Histone Code;In Vitro;Investigation;Link;Liquid substance;Maintenance;Malignant Neoplasms;Mediating;member;Membrane;Methylation;MicroRNAs;Modeling;Modification;Molecular;Mothers;Mus;Oogenesis;Organelles;Parasites;Pathway interactions;Phase;Physical condensation;piRNA;Play;Post-Translational Protein Processing;Process;Production;Protein Family;Protein Region;Proteins;recruit;Regulation;Repression;Research;Rest;RNA;RNA Interference;Role;Scaffolding Protein;sex determination;Signal Transduction;Small Interfering RNA;Specific qualifier value;Sterility;System;Therapeutic;tool;Transcript;transmission process;Untranslated RNA;Work

PROJECT_TITLE: Molecular mechanism of the piRNA biogenesis

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Cancer;Hearing Loss;Neurosciences

ORG_CITY: San Diego

ORG_NAME: TING THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE The work in this proposal focuses on further development of TT001 to protect from cisplatin- induced hearing loss, an anticancer drug that leaves 40-60% of the treated cancer patients with high frequency hearing loss. If successful, this proposal will allow Ting Therapeutics to initiate conversations with pharmaceutical companies for the manufacturing and commercialization of TT001, for its use as a standard otoprotective component of cisplatin-based therapies.

PI_NAMEs: HUANG, YUNLONG  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Aftercare;Animal Model;Animals;anticancer activity;Antineoplastic Agents;Antioxidants;Audiology;Auditory;Auditory Brainstem Responses;authority;Award;Blood;Cancer cell line;Cancer Patient;cancer therapy;Cavia;CDK2 gene;Cell Death Induction;Cell Line;Chemicals;China;Cisplatin;cisplatin induced hearing loss;Clinical;Clinical Treatment;Clinical Trials;Cochlea;commercial application;commercialization;Contracts;Data;design;Detection;Development;Dose;Drug Kinetics;Drug usage;Ear;efficacy study;Europe;experience;experimental study;Freedom;Future;Glutathione Metabolism Pathway;Goals;good laboratory practice;guinea pig model;Hair Cells;healthy volunteer;hearing impairment;hearing loss treatment;hearing preservation;Hearing Protection;High Pressure Liquid Chromatography;high throughput screening;High-Frequency Hearing Loss;Hong Kong;Human;Immunohistochemistry;in vitro activity;in vivo;inhibitor;International;Investigational Drugs;Japan;Knowledge;Labyrinth;Legal patent;Licensing;Malignant neoplasm of testis;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Measures;Mediation;Methods;Morphology;mouse model;Mus;neoplastic cell;New Drug Approvals;Observational Study;Oral;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Patients;Perilymph;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 1 study;preclinical trial;prevent;prevent hearing loss;Procedures;Protocols documentation;Publishing;Quality of life;Regimen;research clinical testing;Research Contracts;Rights;Rodent Model;safety and feasibility;Saint Jude Children's Research Hospital;Small Business Innovation Research Grant;Sodium Chloride;sodium thiosulfate;technological innovation;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Toxicology;tumor;tumor xenograft;United States Food and Drug Administration;vitamin metabolism;webinar;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: CDK2 inhibitors for protecting hearing loss


NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: KAY, STEVE A (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Molecular Mechanisms in the Arabidopsis Circadian Clock

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Narrative This Veterinary Student Research Training program (VSRTP) at Texas A&M University addresses a critical national need for veterinarians in biomedical research. Veterinarians have a unique understanding of health and disease at the organismal level of a variety of animal species, and increased numbers of veterinarians in research would alleviate this national shortage. Our evolving T35 programmatic goal is to stimulate veterinary students to consider a veterinary career in biomedical research by providing them with rich, immersive summer training experiences under the direction of NIH-funded mentors in robust biomedical research programs. In this T35 renewal, we will both facilitate novice trainees to discover research as an exciting career option, as well as further develop the research and scientific communication skillsets of trainees with previous research experience and help to solidify their interest and commitment to a veterinary career in biomedical research.

PI_NAMEs: GADDY, DANA  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Advisory Committees;Animal Model;Attention;base;biodefense;Biomedical Research;Cardiovascular Diseases;career;Chronic;Collaborations;Communication;Comparative Biology;Development;Diabetes Mellitus;dietary;Disease;Environment;Evaluation;experience;Extramural Activities;fetal;Funding;Goals;Health;Health Professional;health training;Hour;Human;Individual;Institution;interest;journal article;Laboratories;Manuscripts;Medical Students;Mentors;National Research Council;Oral;Positioning Attribute;posters;pre-clinical;Preparation;Primates;programs;Qualifying;recruit;Reporting;Research;Research Methodology;Research Project Grants;Research Training;responsible research conduct;skills;Source;Students;success;summer program;symposium;Texas;Toxin;Training;Training Programs;Translational Research;United States National Academy of Sciences;United States National Institutes of Health;Universities;Vaccines;Veterinarians;Veterinary Medicine;Wages;Zoonoses

PROJECT_TITLE: Veterinary Medical Student Research Training


ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal focuses on the structure and function of metal ion receptors that translate fluctuations in zinc concentration into changes in cellular processes. These metalloprotein studies will characterize the fundamental zinc-receptor proteins that control cell cycle progression. This proposal will also develop emerging physiochemical methods and new chemical probes to characterize the zinc fluxes that ultimately govern cellular growth and division.

PI_NAMEs: O'HALLORAN, THOMAS V (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: absorption;Affinity;anaphase-promoting complex;Antibodies;APC2 gene;Binding;Binding Sites;Biochemical;Biochemistry;Biological Models;biophysical techniques;Cancer Biology;Catalysis;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell growth;Cell Physiology;Cells;Chemicals;cofactor;Communication;Complex;Data;Development;Diffusion;Disease;egg;Embryo;emission spectroscopy;Environment;Enzymes;Event;experimental study;Fertilization;Funding;genetic regulatory protein;Genetic Transcription;Goals;Homologous Gene;Hour;Human;Immune response;Immunology;in vivo;innovation;Inorganic Chemistry;insulin secretion;interdisciplinary approach;Invertebrates;Ions;Kinetics;Laboratories;Life;Light;live cell imaging;Locales;Location;Mammalian Cell;Manganese;Maps;Mass Spectrum Analysis;Mediating;Mediator;Meiosis;Metabolic;Metalloproteins;Metals;Methodology;Methods;Microscopy;Mitosis;Mitotic;Modeling;Molecular;Molecular Conformation;Movement;Mus;Neurobiology;Neurons;novel;oocyte maturation;Pathway interactions;Periodicity;Phosphorylation;Physiology;Play;Process;protein structure;Proteins;Protocols documentation;Rana;Reaction;Reagent;receptor;reconstitution;Regulation;response;Rest;Roentgen Rays;Role;sensor;Series;Signal Transduction;Site;Somatic Cell;Spectrum Analysis;Structure;Structure-Activity Relationship;success;System;Techniques;Tertiary Protein Structure;Testing;Thermodynamics;tool;trafficking;transcription factor;Translating;ubiquitin ligase;Zinc

PROJECT_TITLE: Regulatory Roles of Zinc Fluxes in Metalloprotein Occupancy and Cell Cycle Progression

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lymphatic Research;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Breast cancer, the most common cancer in women, often metastasizes to nearby lymph nodes. A biopsy marker is placed in a metastatic lymph node for later ultrasound localization and surgical removal, but in a significant number of cases ultrasound detection of the marker can fail to locate the proper lymph node, so better markers are needed for improved treatment outcomes. Successful completion of this project will yield markers that 1) are conspicuous on ultrasound, and 2) do not migrate from the site of implantation.

PI_NAMEs: LEE, CHRISTINE U.;URBAN, MATTHEW WILLIAM (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;3D Print;absorption;Address;Adhesions;Affect;Animal Model;arm;Axilla;Axillary Lymph Node Dissection;Axillary lymph node group;Biopsy;Breast;Breast biopsy;Breast Cancer Patient;Breast Cancer Treatment;cancer recurrence;cancer therapy;candidate marker;Caring;Characteristics;Chemicals;chemotherapy;Clinical;clinical practice;Clinical Trials;Color;comparative;cost;Data;design;Detection;Development;Dissection;Doppler Ultrasound;efficacy testing;Engineering;Excision;Family suidae;Goals;Growth;Health Care Costs;Image;imaging modality;Implant;implantation;improved;In complete remission;Kidney Calculi;Location;Longevity;lymph nodes;Lymphedema;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;manufacture;materials science;Measurement;Medicine;Methods;microCT;migration;Monitor;Morbidity - disease rate;Morphologic artifacts;Morphology;multidisciplinary;Neoadjuvant Therapy;Neoplasm Metastasis;Operative Surgical Procedures;Optics;Outcome;Pathologic;Patients;Phase I Clinical Trials;Physics;Play;Polymethyl Methacrylate;porcine model;Positive Axillary Lymph Node;Positive Lymph Node;preservation;Procedures;Process;Radiation therapy;Radiology Specialty;recruit;Research;Research Project Grants;Resistance;Retrieval;Role;Safety;safety assessment;Scanning;Scanning Electron Microscopy;Sentinel Lymph Node;side effect;signal processing;Site;Specificity;standard of care;Surface;Surgeon;Surgical Mesh;Surgical Oncology;Systemic Therapy;Testing;Time;Tissues;Translating;Treatment outcome;Ultrasonography;ultrasound;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Development of an ultrasound detectable, migration-resistant biopsy marker for improving care in patients with breast cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Neural stimulation is a tool to probe neural circuits and recover functionality after brain damage. Current probes stimulate sparse, distributed neural populations. This proposal details an innovative wireless in vivo stimulation technology that will enable precise neural circuit probing with an improved chronic tissue interface.

PI_NAMEs: KOZAI, TAKASHI DANIEL YOSHIDA (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Subcellular Wireless Axons for in vivo Localized Neuronal Excitation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative In addition to containing the blueprints for proteins, mRNAs also contain sequences called 3′UTRs. We found that 3′UTRs can change protein functions by allowing assembly of new protein complexes. Here we describe a systematic approach to identify 3′UTR-dependent functions for large sets of genes.

PI_NAMEs: MAYR, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Binding Proteins;Cell Death;Cells;Code;CRISPR/Cas technology;Cytoplasmic Granules;Cytosol;Development;Elements;Engineering;Environment;Genes;Goals;Length;Mediating;Membrane;Messenger RNA;Methods;migration;Organelles;Phase;Post-Translational Protein Processing;protein aggregation;Protein Biosynthesis;protein complex;protein function;Protein Isoforms;protein protein interaction;Proteins;recruit;Regulation;Research;Role;scaffold;Therapeutic;Transcript;Translating;Translations;Untranslated Regions

PROJECT_TITLE: Regulation of protein multi-functionality by 3 UTRs

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE We recently identified a novel subnuclear structure that controls alternative RNA splicing and gene co-regulation in the heart. This proposal will reveal how mutations leading to severe heart disease affect the organization and activity of this structure, and will identify new factors that are essential for its function. This work will clarify the molecular mechanisms that connect alterations in nuclear sub-compartmentalization to heart development and reveal novel molecular targets for therapeutic intervention in cardiac disease.

PI_NAMEs: MURRY, CHARLES E (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Action Potentials;Adherent Culture;Adult;Affect;Alternative Splicing;Amino Acids;Architecture;Area;Arrhythmia;Binding Sites;Biochemical;Biogenesis;Biophysical Process;biophysical properties;Biophysics;Biotinylation;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardiogenesis;Cardiomyopathies;Cells;Chromatin;Chromatin Structure;Chromosomes;cofactor;Collaborations;connectin;CRISPR/Cas technology;Data;Deoxyribonucleases;Development;Dilated Cardiomyopathy;Disease;Dissection;Electrophysiology (science);Engineering;experimental study;Functional disorder;Gene Expression;Genes;Genetic Transcription;genome editing;genome-wide;genomic locus;Goals;Hand;Heart;Heart Diseases;Heart failure;heart function;Hi-C;Human;human pluripotent stem cell;Image;imaging modality;in vivo;insight;L-Type Calcium Channels;Laboratories;Left;Link;Liquid substance;loss of function;Membrane;membrane assembly;Messenger RNA;Methods;Modeling;Molecular;molecular dynamics;molecular targeted therapies;mRNA Precursor;multiple omics;Muscle;Muscle Proteins;mutant;Mutation;Myocardial;new therapeutic target;novel;Nuclear;Oligonucleotides;Onset of illness;Pathogenesis;Pathogenicity;Patients;Phase;Phenotype;Physical condensation;Physiological;Play;Property;Protein Isoforms;Proteins;Regulation;release of sequestered calcium ion into cytoplasm;Reporter;RNA;RNA Binding;RNA Splicing;Role;Sampling;scaffold;Spliced Genes;Structure;superresolution microscopy;Testing;Therapeutic Intervention;therapeutic target;tool;Work

PROJECT_TITLE: Function, composition, and mechanism of RNA splicing factories in cardiomyopathy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project addresses the challenge of caring for patients with a class of lung disease called idiopathic pulmonary fibrosis, which has short survival and few therapeutic options. Our group has developed a new radiotracer that can be used in a positron emission tomography (PET) scan to image specific inflammatory cells called CCR2+ monocytes that are considered to be pathogenic in pulmonary fibrosis. Proposed studies will use mouse models of lung fibrosis to assess molecular therapies that blocks CCR2 cells to determine if the response can be monitored by CCR2-PET and in patients with pulmonary fibrosis, to substantiate the relationship between the CCR2-PET imaging and the population of CCR2+ cells in fibrotic lungs.

PI_NAMEs: BRODY, STEVEN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Animal Model;antagonist;antifibrotic treatment;Attenuated;Biological Markers;Biopsy;Bleomycin;bone cell;Bone Marrow;Cells;cellular imaging;Cessation of life;chemokine receptor;chest computed tomography;Clinical;clinical effect;Cytometry;Data;Detection;Development;Diagnosis;Diagnostic;Disease;dosimetry;Fibrosis;fibrotic lung;fibrotic lung disease;first-in-human;Fostering;Gene Expression;Genetic;High Resolution Computed Tomography;Human;human disease;idiopathic pulmonary fibrosis;Image;image guided;imaging study;Immune;indium-bleomycin;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Interleukins;interstitial;Interstitial Lung Diseases;irradiation;Knockout Mice;Location;Lung;lung development;Lung Diseases;lung injury;Lung Transplantation;Macrophage;Mediating;Mediator;Modeling;Molecular;molecular imaging;molecular marker;Molecular Target;molecular targeted therapies;Monitor;monocyte;mouse model;multidisciplinary;Mus;Nature;nintedanib;non-invasive monitor;Outcome;Pathogenicity;Pathologic;Pathway interactions;Patient Care;Patient imaging;Patient Monitoring;Patients;Pattern;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Phase 0/1 Trial;Phenotype;Pirfenidone;Population;Positron-Emission Tomography;Prediction of Response to Therapy;Process;profibrotic cytokine;Profibrotic signal;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Radiation;radiotracer;Reporter;Reproducibility;response;Risk;Role;safety study;Severities;Signal Transduction;Sorting;Specificity;Structure of parenchyma of lung;Subgroup;targeted treatment;Testing;Therapeutic;Transcript;transcriptome sequencing;Transplantation;treatment response;uptake;X-Ray Computed Tomography

PROJECT_TITLE: Molecular Imaging CCR2 Lung Inflammation and Fibrosis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Sleep Research

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Memories are highly dependent upon the context in which they are embedded, yet neurocognitive models of human sleep consolidation downplay the role of context and focus instead on the reactivation (or “replay”) of individual, isolated memory traces. This proposal will disentangle the roles of individual memories and generalized contexts in sleep-related reactivation using functional MRI, EEG and behavioral methods for sleep manipulation, thereby creating a unified framework linking the context-memory literature, the nonhuman replay literature, and the human reactivation literature. The possibility of reinstating context during sleep will be exploited to weaken memories reactivated in a suppression context, providing evidence for the translational nature of the developed framework and possibly paving the way toward non-invasive memory-altering interventions for healthy and clinical populations.

PI_NAMEs: SCHECHTMAN-DRAYMAN, EITAN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Animals;Applied Research;arm;Auditory;Award;Basic Science;Behavior;Behavior Control;Behavioral;Biological Sciences;Brain;California;career;Clinical;clinically relevant;Cognition;Complement;Comprehension;Computer Models;Computing Methodologies;Cues;Data;Data Analyses;Decision Making;Dependence;design;Development;Dimensions;Electroencephalography;Electrophysiology (science);Event;experience;experimental study;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Hippocampus;Human;human model;improved;Individual;Infrastructure;Intervention;Learning;Life;Link;Literature;machine learning algorithm;Memory;memory consolidation;memory process;Mental disorders;Mental Health;Mentors;Methods;Modeling;Molds;Monitor;Multivariate Analysis;Nature;Network-based;neural;neural patterning;Neurobiology;Neurocognitive;Neurons;novel;Odors;outreach;Participant;Pattern;Personal Satisfaction;Phase;Play;Population;Post-Traumatic Stress Disorders;Process;Prognosis;Research;Retrieval;Role;Schools;Semantics;skills;Sleep;sound;spatiotemporal;Stimulus;Symptoms;Techniques;Testing;Training;Training Support;Trauma;Universities;Vacuum;Work

PROJECT_TITLE: The role of context in sleep-related memory reactivation in humans


NIH_SPENDING_CATS: Disability Research;Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Human;Traumatic Head and Spine Injury

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Many neurological conditions disrupt connections between surviving neurons. The regeneration of axons has the potential to provide functional neurological recovery, without requiring “new” cells from transplantation or from neurogenesis. Unfortunately, the CNS of adult mammals, as compared to the peripheral nervous system or nervous system of other organisms, has extremely limited capacity for axon regeneration. We have developed screening methods to identify those genes limiting the repair of axons in the mammalian CNS. We will evaluate regeneration-limiting genes using model organisms, biochemical methods and translational models of traumatic spinal cord injury.

PI_NAMEs: STRITTMATTER, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Axon;axon growth;axon regeneration;axonal sprouting;Biochemical;Bioinformatics;Bladder;Cell Transplantation;Development;disability;Future;Gene Deletion;Genes;genome-wide;Human;Individual;injury recovery;Intestines;Locomotion;Mammals;Medical;Methods;model organism;Movement;Natural regeneration;Nematoda;Nervous System;neural repair;neurogenesis;Neurologic;Neurologic Deficit;neurological recovery;neuronal survival;Neurons;novel therapeutics;Organism;Pathway interactions;Patients;Peripheral Nervous System;pharmacologic;Phosphoric Monoester Hydrolases;Pre-Clinical Model;prevent;receptor;Recovery;repaired;Role;screening;small hairpin RNA;Spinal cord injury;Testing;therapeutic development;translational model;Translational Research;Wheelchairs

PROJECT_TITLE: Genome-Wide Discovery and Translational Research for Neural Repair


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The studies proposed in this application will have a direct beneficial effect on the health of millions of people worldwide who are infected with or at risk for HIV, tuberculosis and hepatitis B, transforming the health of people with these infections. The clinical research conducted by the ACTG will lead to significantly reducing morbidity and mortality, particularly among populations disproportionately affected by HIV/AIDS.

PI_NAMEs: CURRIER, JUDITH S. (contact);ERON, JOSEPH J

PROGRAM_OFFICER_NAME: OJUMU, AKINLOLU O

PROJECT_TERMS: active method;acute infection;Address;Affect;aging related;AIDS clinical trial group;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Area;Behavioral;Biological Markers;Blood;burden of illness;California;Cardiovascular system;chronic infection;Clinical;Clinical Research;Clinical Trials;Collaborations;collaboratory;Communication;community engagement;community involvement;comorbidity;comparative efficacy;Conduct Clinical Trials;Data Coordinating Center;design;Development;Disease;Disease remission;Drug resistance in tuberculosis;drug-sensitive;efficacy trial;Epidemic;Evaluation;Funding;Goals;Health;Hepatitis B;Hepatitis B Virus;HIV;HIV Infections;HIV/AIDS;Immune;Immunologics;improved;Industry Collaboration;Infection;Infrastructure;innovation;International;Intervention;Knowledge;Laboratories;Leadership;Los Angeles;Maintenance;Mental Health;Metabolic;Morbidity - disease rate;mortality;multidisciplinary;Multidrug-Resistant Tuberculosis;Neurologic;neutralizing antibody;novel;Obesity;Occupational activity of managing finances;operation;Persons;Phase;Population;prevent;Prevention;Prevention and Treatment of Opportunistic Infection;protocol development;Protocols documentation;Publishing;Regimen;Research;Research Personnel;Resources;Risk;Science;social;Specimen;statistics;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic vaccine;Tissues;Training;treatment guidelines;Tuberculosis;Universities;Virus Diseases

PROJECT_TITLE: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Tauopathies are devastating neurodegenerative diseases that impair cognition, memory, movement, strength, and vision. There are no cures, and all tauopathy diseases are fatal. There is a critical need to identify ways to treat tauopathy patients and to prevent functional debilitation arising from tauopathy neurodegenerations. In this VA Merit award, we test an exciting, new strategy to treat tauopathy by enhancing EIF2AK3/PERK signaling, based on our prior findings that this pathway significantly increased risk for developing tauopathy neurodegenerations when defective in patients. We will evaluate neurologic outcomes and survival in preclinical animal models after genetic or chemical EIF2AK3/PERK activation. We will also characterize new small molecule EIF2AK3/PERK chemicals as potential drugs to combat tauopathy. Our studies will benefit Veterans by identifying new drug treatments to maintain healthy brain function and prevent neurodegeneration especially those carrying genetic risk factors.

PI_NAMEs: LIN, JONATHAN  (contact)

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Animals;Award;behavior test;Biochemical;biological adaptation to stress;Biological Availability;blast exposure;blood-brain barrier crossing;Brain;Brain Pathology;Brain region;Cell Death Induction;Cells;Cellular Assay;Chemicals;chronic traumatic encephalopathy;Cognition;Cognitive;combat;Control Groups;Craniocerebral Trauma;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Disease;Dose;Drug Screening;Drug Targeting;Elderly;endoplasmic reticulum stress;Equilibrium;experimental group;experimental study;FDA approved;functional decline;Funding;Genetic;Genetic Enhancement;genetic risk factor;Human;Huntington Disease;Impaired cognition;Impairment;improved;In Vitro;Injury;Intellectual Property;life span;Locomotion;Measures;Memory;Mission;Modeling;Morbidity - disease rate;mouse model;Movement;Mus;Mutant Strains Mice;Nerve Degeneration;Nervous Mouse;Nervous System;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurological outcome;Neurons;novel;novel therapeutics;Onset of illness;Oral;Outcome;Oxidative Stress Induction;Pathologic;Pathology;Pathway interactions;Patients;PERK kinase;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phenotype;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphotransferases;pre-clinical;precision medicine;preclinical development;preclinical study;preservation;prevent;Process;Property;protein aggregation;protein misfolding;protein structure;Reducing Agents;Regulation;Resources;response;Risk;risk variant;Signal Transduction;small molecule;small molecule libraries;stem cells;Stress;Stress Response Signaling;survival outcome;tau Proteins;Tauopathies;Testing;Therapeutic;tool;Translating;Treatment Protocols;Variant;Veterans;Veterans Health Administration;Vision

PROJECT_TITLE: Endoplasmic Reticulum Stress in Neurodegeneration

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health as it will provide optimized tools for mobile assessment of cognitive information processing in clinical and nonclinical populations, over time, and with greater ecological validity. The project is relevant to NIMH's mission to understand the mechanisms of complex brain disorders as it will provide tools for understanding dynamic variations in cognitive information processing of threat and how these are related to psychiatric symptoms.

PI_NAMEs: GERMINE, LAURA THI (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;Address;Anxiety;Attention;Benchmarking;Brain Diseases;Characteristics;Clinical;Cognition;Cognitive;cognitive change;cognitive testing;cohort;college;Communities;Complex;Controlled Environment;design;Development;Devices;digital;Dimensions;Ecological momentary assessment;Environment;experience;field study;follow-up;Frequencies;Fright;germine;Goals;handheld mobile device;Hospitals;Hour;improved;Individual;information processing;Infrastructure;innovation;Investigation;Laboratories;Link;Literature;Measures;Medicine;Mental disorders;Mental Health;Mission;Monitor;National Institute of Mental Health;Outcome;Participant;Patient Self-Report;Performance;performance based measurement;Persons;Phenotype;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Procedures;Property;psychiatric symptom;Psychiatric therapeutic procedure;Psychometrics;Psychopathology;Psychoses;Public Health;recruit;Reporting;Reproducibility;Research;Research Design;Research Domain Criteria;Resources;Role;Sampling;Science;Self Administration;smartphone based assessment;sociodemographics;Specific qualifier value;Stimulus;Symptoms;Testing;Time;tool;trait;Validation;validation studies;Variant;Work

PROJECT_TITLE: Mobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal Assessment

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The goal of this proposal is to synthesize, characterize and assess discrete luminescent lanthanide complexes for the targeted, activatable optical imaging of cancer by in situ excitation of luminescence by Cherenkov radiation produced by positron emitting radioisotopes.

PI_NAMEs: BOROS, ESZTER  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Affinity;analog;Bilateral;Binding;Biodistribution;Biological;biomaterial compatibility;Bombesin;Bombesin Receptor;cancer cell;cancer heterogeneity;cancer imaging;cancer therapy;Carcinoma in Situ;Cells;Characteristics;Charge;Chemicals;Cherenkov Radiation;chromophore;Clinical;clinical imaging;Complex;design;detection limit;Diagnosis;Disease;Disease Marker;Dose;Drug Kinetics;Dyes;Embryo;Energy Transfer;Europium;Evaluation;Excision;Exhibits;fluorodeoxyglucose;fluorophore;FOLH1 gene;Generations;Goals;Hepatic;Human;imaging probe;imaging study;improved;In Situ;In Vitro;in vivo;in vivo imaging;in vivo optical imaging;interest;Investigation;Ions;Isotopes;kidney cell;Lanthanoid Series Elements;lipophilicity;LNCaP;luminescence;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Modeling;Mole the mammal;Molecular;Monitor;multiplexed imaging;Mus;Nature;Operative Surgical Procedures;optical imaging;Optics;particle;PC3 cell line;polypeptide;Positron;Positron-Emission Tomography;precision medicine;preclinical imaging;prevent;Property;prostate cancer cell line;quantum;Radioactive;Radioisotopes;Radiolabeled;radiotracer;Signal Transduction;Source;Technology;Terbium;Tissues;Toxic effect;treatment response;tumor;Tumor Markers;tumor xenograft;uptake;Urea;Visualization;Visualization software;Water;water solubility

PROJECT_TITLE: Cherenkov luminescence mediated excitation of discrete lanthanide optical probes

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative It is poorly understood how tumor killing capacity of CD8+ T cells (CTLs) is affected by tumor metabolism in the tumor microenvironment. We will explore the cellular and molecular mechanisms by which CTL-tumor killing potency is affected by amino acid circuits in tumor cells and demonstrate how tumor stiffness is involved into this process. The proposal will provide an opportunity to take our understanding of the cross-talk between CTLs and tumor cells to a new level of mechanism and application.

PI_NAMEs: ZOU, WEIPING  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Aerobic;aerobic glycolysis;Affect;Air Movements;amino acid metabolism;Amino Acid Transporter;Amino Acids;Attention;Biological;Biomechanics;Breast Cancer Cell;cancer cell;cancer genetics;cancer stem cell;cancer therapy;CD8-Positive T-Lymphocytes;cell killing;Cell membrane;Cell Proliferation;Cells;Characteristics;Chemoresistance;Cytoplasmic Granules;cytotoxic;cytotoxic CD8 T cells;Data;Development;DNA Sequence Alteration;Effector Cell;effector T cell;Elasticity;empowerment;Epigenetic Process;Event;FOXP3 gene;Genetic;Glutamine;Goals;Granzyme;Human;Hypoxia;imaging system;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immune response;Immune system;Immunity;Immunologic Sensitization;Immunologics;Immunology;Immunotherapeutic agent;Immunotherapy;Impairment;interdisciplinary approach;Interferons;laser tweezer;Link;Lytic;Malignant Neoplasms;mass spectrometric imaging;Measurement;Mechanics;Mediating;Mediator;Membrane;Metabolic;Metabolism;Microscope;migration;Molecular;Mus;Mutation;Myeloid-derived suppressor cells;Myosin Type II;Nature;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;Oncology;optic tweezer;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;perforin;Phenotype;Predisposition;Process;Regulation;Regulatory T-Lymphocyte;Research;Resistance;resistance mechanism;Role;Scanning Probe Microscopes;Signal Pathway;Solid Neoplasm;Spectrometry, Mass, Electrospray Ionization;stem-like cell;stemness;T-Lymphocyte;Techniques;Testing;Tissues;tool;trafficking;tumor;Tumor Immunity;tumor initiation;tumor metabolism;tumor microenvironment;uptake;Warburg Effect

PROJECT_TITLE: CTL-killing capacity and cancer stiffness in cancer immunity and therapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Chemical damage to DNA occurs frequently and blocks the progression of the replisome, the multiprotein complex responsible for replicating chromosomes. Translesion synthesis is an error-prone DNA damage tolerance pathway that directly bypasses DNA lesions, resolving these dangerous replication blocks. This project uses advanced single-molecule microscopy approaches along with biochemical and genetic assays to determine the mechanism and regulation of translesion synthesis.

PI_NAMEs: LOPARO, JOSEPH J. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Ablation;Acceleration;Affect;Antibiotic Resistance;Antimicrobial Resistance;Binding;Binding Sites;Biochemical;Biological Assay;Bypass;C-terminal;Cell Death;Cells;Chemicals;chromosome replication;Closure by clamp;Complex;Dangerousness;Data;Development;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Polymerase II;DNA Polymerase III;DNA replication fork;Double Strand Break Repair;Escherichia coli;Event;Exclusion;Filament;Fluorescence Resonance Energy Transfer;Funding;Genetic;genetic approach;Genome Stability;Genomic Instability;Hand;helicase;Image;In Vitro;Kinetics;Left;Length;Lesion;Mediating;Methyl Methanesulfonate;Microscopy;Molecular;Molecular Conformation;molecular imaging;Multiprotein Complexes;Mutagenesis;mutant;Pathway interactions;Play;Polymerase;Property;Proteins;reconstitution;recruit;Regulation;repaired;Resolution;Role;Signal Transduction;single molecule;single-molecule FRET;Single-Stranded DNA;Site;Source;stoichiometry;Surface;Tail;Testing;tumor progression;Work

PROJECT_TITLE: Regulation of translesion synthesis by the bacterial replisome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Women's Health Research

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE South Africa has the world’s largest HIV treatment program and the second highest TB incidence, with TB the leading cause of death. The overall Stellenbosch Clinical Trials Unit objective is to collaboratively design and implement high-impact clinical research that will result in safe, patient- and-family-centered, effective prevention, treatment and remission of HIV and related comorbidities, and TB prevention, diagnosis, and treatment, across all age groups.

PI_NAMEs: BARNABAS, SHAUN ;HESSELING, ANNEKE CATHARINA (contact)

PROGRAM_OFFICER_NAME: SOUTHARD, COURTNEY MEAGAN

PROJECT_TERMS: Address;Adjuvant;Adolescent;Adult;Age;age group;aged;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Anti-retroviral resistance;antiretroviral therapy;Antitubercular Agents;Area;aspirate;bactericide;Biological Markers;Biopsy;Breast Feeding;Bronchial Lavages;Cardiovascular Diseases;Cause of Death;Cerebrospinal Fluid;Child;Clinical Research;clinical research site;Clinical Trials Unit;co-infection;Collaborations;comorbidity;Competence;Country;Critical Illness;Cytomegalovirus;design;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Disease remission;Drug Interactions;Drug Kinetics;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Drug user;Family;family support;Formulation;Foundations;Hepatitis;Hepatitis B;high risk population;HIV;HIV Seronegativity;HIV Seropositivity;HIV vaccine;HIV Vaccine Trials Network;HIV-exposed uninfected infant;HIV-infected adolescents;HIV/TB;Hospitalization;Image;immunogenicity;Immunology;Incidence;Infant;Infectious Agent;interest;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Kaposi Sarcoma;Kidney Diseases;Laboratories;Lead;Liver diseases;Low Birth Weight Infant;Lung;Lung Diseases;lung health;lymph nodes;lymphadenopathy;Lymphoma;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Medical;men who have sex with men;Meningeal Tuberculosis;Mental Health;Microbiology;Modality;Neurocognitive Deficit;neurodevelopment;neutralizing antibody;novel;novel vaccines;Nuclear Pore Complex;Patients;Persons;Pharmaceutical Preparations;Phase;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;Predisposition;pregnant;Pregnant Women;Premature Infant;prevent;Prevention;Protocols documentation;Pulmonary Tuberculosis;Regimen;Research;Research Priority;Resistance;Risk;Safety;safety study;Sampling;sex;Site;South Africa;Special Population;Sputum;Structure of parenchyma of lung;System;Target Populations;Technology;Therapeutic Research;transgender;treatment adherence;treatment program;Treatment Protocols;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;Tuberculosis Vaccines;Universities;vaccine candidate;vaccine trial;Vertical Disease Transmission;Woman;Youth

PROJECT_TITLE: Stellenbosch University Clinical Trials Unit


PHR: Project Narrative Selective oxidation of organic molecules represents one of the key reaction classes available for the synthesis and discovery of pharmaceutical intermediates and therapeutic agents. The research outlined in this proposal will develop a broad range of new oxidation methods that achieve selective formation of new carbon-carbon and carbon-heteroatom bonds.

PI_NAMEs: STAHL, SHANNON S (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Catalytic Oxidations for Pharmaceutical Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Physical Activity;Prevention

PHR: RELEVANCE TO PUBLIC HEALTH Patients are almost universally advised to exercise and lower cholesterol to reduce cardiovascular disease, including calcium deposits in the arteries, which increase the risk of morbidity and mortality. Paradoxically, both elite endurance athleticism and use of statin-class drugs are associated with increased coronary artery calcification. Thus, it is essential to determine the mechanism of this increase and whether the increase in calcium deposition occurs in a manner that increases or decreases risk of rupture.

PI_NAMEs: DEMER, LINDA L. (contact);TINTUT, YIN

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Aorta;Area;Arteries;biomechanical test;Blood Vessels;Bone Growth;calcification;Calcium;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Catheters;Cholesterol;Clinical;Clinical Research;coronary artery calcification;coronary plaque;density;Deposition;Diet;Dose;Equilibrium;Event;Exercise;exercise capacity;experience;Face;Female;Fluorides;Genetic Models;Genetic Transcription;genome wide screen;Health Status;Heterozygote;high risk;Hormone Antagonists;Hormone Receptor;Human;Hyperlipidemia;Immunohistochemistry;improved;in vivo;Individual;Injections;Label;Lesion;Link;male;Measures;Mechanics;Minerals;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;novel;nuclear imaging;Parathyroid Hormone Receptor;parathyroid hormone-related protein;Parathyroidectomy;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Physical activity;Porosity;Positron-Emission Tomography;predictive modeling;PTH gene;Public Health;Receptor Activation;receptor expression;Regimen;Regulation;Research;response;Risk;Role;Rupture;sedentary;sensor;Serum;sex;Signal Transduction;Smooth Muscle Myocytes;Strenuous Exercise;Stress;structural imaging;Surface;Surgical Models;Testing;Tissues;transcriptome;treadmill;Up-Regulation;uptake;Vascular calcification;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative While inflammation is critical for elimination of different microbial insults such as bacteria, viruses and fungi, unwarranted inflammation such as in the case of autoinflammatory and auto-immune diseases is a cause of severe morbidity and mortality. We have discovered that auto-reactive CD4 T cells have the capacity to activate the innate immune system, independent of microbial recognition, to produce inflammatory cytokines and chemokines that cause tissue destruction and pathology. In this proposal, we intend to study the exact molecular mechanisms by which effector and effector memory CD4 T cells cause innate inflammation so that specific molecules can be targeted for therapy against auto-immunity and other T cell driven inflammatory diseases.

PI_NAMEs: PASARE, CHANDRASHEKHAR  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;arm;ataxia telangiectasia mutated protein;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;autoinflammatory diseases;Automobile Driving;autoreactive T cell;autoreactivity;B-Lymphocytes;Bacteria;Bypass;CASP8 gene;CD4 Positive T Lymphocytes;Cell Communication;Cell Lineage;Cells;chemokine;Clinical Treatment;Clonal Expansion;Code;Cues;cytokine;cytokine release syndrome;Data;Dendritic Cells;Disease;DNA Damage;effector T cell;Event;fungus;Gene Expression Profile;Generations;Genes;IL1R1 gene;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;insight;Instruction;Interferons;Intestines;Invaded;Investigation;Joints;Kidney;Ligands;Lymphoid Tissue;Macrophage;member;Memory;memory CD4 T lymphocyte;microbial;Molecular;Morbidity - disease rate;mortality;Mutation;Myeloid Cells;Natural Immunity;Nature;novel;Nuclear;Organ;Outcome;Pancreas;pathogen;Pathologic;Pathology;Pathway interactions;Pattern recognition receptor;Peptide/MHC Complex;Peptides;Play;Population;Process;Production;programs;receptor;Receptor Activation;Regulation;response;Role;secondary lymphoid organ;sensor;Signal Transduction;Skin;Stimulator of Interferon Genes;Surface;Syndrome;T memory cell;T-Cell Activation;T-Lymphocyte;targeted treatment;terminally differentiated effector memory (TEM) T cells;Tissues;TNF gene;TNFRSF5 gene;Toxin;transmission process;Tumor Necrosis Factor Receptor;Up-Regulation;Uric Acid;Virus;Work

PROJECT_TITLE: Innate mechanisms of regulation of Th17 responses


ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Narrative (Overall) We will establish the San Antonio-based Coccidioidomycosis Collaborative Research Center at San Antonio (SA-CCRC). This Center includes three Research Projects to conduct basic, translational and clinical research in the field of coccidioidomycosis, two technical Cores to bring novel technologies to this field, and an Administrative core to coordinate all activities in this program and support and mentor junior investigators and those who are new to the field of coccidioidomycosis. The Center creates a cohesive infrastructure to support integrated and highly synergistic research with a focus on development of antifungal drugs and vaccines against coccidioidomycosis which are urgently needed.

PI_NAMEs: HUNG, CHIUNG-YU  (contact);LOPEZ-RIBOT, JOSE L.

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;anti-fungal agents;Antibiotic Resistance;Area;arid land;Arizona;Azole resistance;Basic Science;Bioinformatics;California;career development;Cells;Clinical;Clinical Research;clinically significant;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Communities;Data;desert fever;design;Development;Disease Outcome;drug development;Drug Screening;Ensure;Evaluation;experience;Funding;Genomics;Geographic Locations;Goals;Health;Health Care Costs;high throughput screening;Immunity;Immunocompromised Host;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Individual;industry partner;Infection;Infrastructure;Institution;instrumentation;Investigator-Initiated Research;Knowledge;Libraries;Lung;Medical;member;Mentors;Messenger RNA;Modeling;Morbidity - disease rate;Mycoses;new technology;next generation;novel;Office of Administrative Management;operation;Persons;Pharmaceutical Preparations;Predisposition;Prevention;programs;Research;research and development;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Site;Southwestern United States;Structure;Talents;Technical Expertise;Techniques;Technology;Testing;The science of Mycology;Therapeutic;therapeutic development;Time;Training;translational pipeline;Translational Research;Treatment outcome;United States;Vaccines;vector-based vaccine

PROJECT_TITLE: SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE (Public Relevance Statement) The basic science of embryo development is important for understanding and preventing congenital disorders in humans. Many aspects of animal development are conserved between species as different as humans and flies, but occasionally even key regulators for the same developmental process differ between closely related species. The goal of this project is to understand how embryos of different fly species adopted unrelated genes for axis specification and anterior pattern formation.

PI_NAMEs: SCHMIDT-OTT, URS C (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Adopted;Affinity;Animals;Anopheles Genus;Anterior;ATAC-seq;Automobile Driving;Basic Science;Binding;Binding Proteins;Binding Sites;C2H2 Zinc Finger;ChIP-seq;Chironomus Genus;Chironomus thummi;Chromatin;chromatin immunoprecipitation;Closure by clamp;Co-Immunoprecipitations;Congenital Disorders;cost;CRISPR/Cas technology;Culicidae;Custom;Deposition;Development;Developmental Biology;Developmental Gene;developmental plasticity;Developmental Process;Diptera;Disease;DNA;DNA Binding Domain;Drosophila genus;Drosophila melanogaster;egg;Embryo;Embryonic Development;Epigenetic Process;Epitopes;Evolution;experimental study;Expression Profiling;Family;fly;Funding;gastrulation;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Gene Targeting;Genes;Genetic;Genetic Transcription;Genetic Variation;Goals;Homeobox Genes;homeodomain;Human;Immune Sera;In Situ Hybridization;in vivo;Injections;Insecta;knock-down;Knowledge;Laboratories;Laboratory Study;Light;Maternal Messenger RNA;Measures;Mediating;Messenger RNA;model organism;Modeling;morphogens;Morphology;mRNA Stability;mRNA Translation;Mutagenesis;Ontology;Organism;Orthologous Gene;Outcome;Pattern;Pattern Formation;Pilot Projects;Positioning Attribute;prevent;Process;Progress Reports;Property;Psychodinae;Research;Ribonucleoproteins;RNA;RNA Interference;RNA-Binding Proteins;Role;Soldier;Source;Specific qualifier value;Specificity;System;Testing;Transcript;transcription factor;transcriptome;Variant;Weight;Zinc Fingers

PROJECT_TITLE: Genetic variation and function of body axis determinants in midges and other flies

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PI_NAMEs: HUNG, CHIUNG-YU  (contact)

PROJECT_TERMS: Accountability;Achievement;Advisory Committees;career;Coccidioidomycosis;data submission;design;Development;Ensure;Extramural Activities;Funding;Goals;Grant;improved;Individual;Institution;Intervention;Leadership;Measures;meetings;Mentors;Mission;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;operation;Outcome;Performance;Preparation;Process;Program Development;programs;Progress Reports;Recommendation;Regulation;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resource Allocation;Resources;Scientist;Structure;Supervision;synergism;therapeutic development;Update;Vaccines;Work

PROJECT_TITLE: SA-CCRC Administrative Core


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Lowering of LDL cholesterol is critical to reduce the risk of heart attacks. PCSK9 is a plasma protein that regulates the LDL receptor in the liver, and its inhibition causes extreme LDL cholesterol lowering and reduces cardiovascular risk. In the first cycle of our grant we discovered that PCSK9 binds to some lipoproteins and that PCSK9-inhibiting antibodies raise plasma PCSK9 levels. These observations set the stage for our new plan of work, which aims at understanding common factors affecting residence time and function of plasma PCSK9 and how these can be exploited to develop new diagnostics or therapeutic leads.

PI_NAMEs: PAMIR, NATHALIE  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acceleration;Affect;Affinity;Antibodies;Apolipoproteins B;Binding;Biological;Biology;Blocking Antibodies;cardiovascular risk factor;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Circulation;Data;Dedications;Diagnostic tests;diagnostic tool;drug development;Event;extracellular;Generations;glycosylation;Grant;Half-Life;Hepatic;Hour;Human;hypercholesterolemia;Impairment;improved;In Vitro;inhibiting antibody;Injections;innovation;Intervention;Investigation;Kinetics;Knowledge;LDL Cholesterol Lipoproteins;Length;Lipoprotein (a);Lipoproteins;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Marketing;Mediating;Metabolic;Metabolic Clearance Rate;Modeling;Modification;Molecular;Monoclonal Antibodies;mouse model;Mus;Mutation;Myocardial Infarction;N-Glycosylation Site;novel;novel diagnostics;novel therapeutics;Output;Paper;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Plasma;Plasma Proteins;Play;Post-Translational Protein Processing;preservation;Production;Productivity;programs;Proprotein Convertases;Protein Degradation Induction;protein function;Proteins;Proteolysis;Regulation;Reporting;Research;residence;response;Risk Reduction;Role;Site;Solid;Subtilisins;success;System;Therapeutic Monoclonal Antibodies;therapeutic target;Time;Work

PROJECT_TITLE: Functional and structural correlates of PCSK9 association with lipoproteins

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Vaccine Related;Valley Fever

PI_NAMEs: LOPEZ-RIBOT, JOSE L. (contact)

PROJECT_TERMS: Academia;Amphotericin B;anti-fungal agents;Antifungal Therapy;Azoles;biocontainment facility;biosafety level 3 facility;cell injury;Cell Membrane Permeability;Cell Wall;Central Nervous System Infections;Clinical;clinically significant;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Communities;cost;Cytology;density;Development;Disease;drug candidate;drug development;drug discovery;Drug Screening;Equipment;Flow Cytometry;Fluconazole;Formulation;fungus;Genomic DNA;Goals;Growth;high throughput screening;Hyphae;Image;Immunotherapeutic agent;in vivo evaluation;Industry;insight;Laboratories;Life;Lung infections;Medical;Methodology;Methods;microorganism;Modeling;Modernization;Mycoses;novel;novel therapeutics;Organism;Outcome;pathogen;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacotherapy;Polyenes;Positioning Attribute;Predisposition;Protocols documentation;Refractory Disease;Research Personnel;Resistance;screening;Services;small molecule libraries;System;Techniques;Testing;The science of Mycology;Therapeutic;therapeutic development;Time;tool;Toxic effect;vaccine candidate;Vaccines;virtual;Work

PROJECT_TITLE: BSL3 Drug Screening Core