NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Biotechnology;Chronic Obstructive Pulmonary Disease;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative  This is a request to upgrade our energy integrating research CT scanner to a photon- counting system (Siemens NAEOTOM Alpha). The requested scanner is a paradigm shift in CT scanning, generating much more anatomic detail while allowing for simultaneously assessing both ventilation and perfusion together with signals of inflammation. Acquisition of this scanner will allow us to more accurately characterize structure to function relationships and to develop protocols which integrate this new technology into critical multi-center studies seeking to better understand COPD, Asthma and more recently long term COVID-19 in addition to allowing us to pursue our own investigations into lung disease etiology.

PI_NAMEs: HOFFMAN, ERIC ALFRED (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: analog;Arteries;Asthma;Characteristics;Chronic Obstructive Pulmonary Disease;Communities;Contrast Media;deep learning;design;Development;digital;Dose;Electronics;Gadolinium;Image;improved;Inflammation;Investigation;Krypton;Light;Location;Long COVID;Lung;Lung Diseases;Methodology;Morphologic artifacts;Multicenter Studies;Noise;Perfusion;Phenotype;photon-counting detector;Photons;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;Protocols documentation;Pulmonary Pathology;Radiology Specialty;Research;Resolution;Scanning;Signal Transduction;Thick;Tissues;transfer learning;Translational Research;Veins;ventilation;X-Ray Computed Tomography

PROJECT_TITLE: NAEOTOM Alpha Photon-Counting CT Scanner

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Endocrine Disruptors;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative/Relevance Per- and polyfluoroalkyl substances (PFAS) may predispose human beings to an elevated risk of developing coronary heart disease (CHD) through modulating blood lipoprotein subspecies that are particularly relevant to CHD etiology, although epidemiological studies that examine inter-relationships among PFAS, blood lipoprotein subspecies, and CHD risk are limited. The proposed research aims to narrow significant knowledge gaps by evaluating prospective associations of PFAS exposures with lipoprotein subspecies and CHD incidence in well-characterized cohort studies of free-living individuals. Data from this research will shed light on potential effects of PFAS on cardiovascular health and may inform policy-making processes for regulating the production and use of PFAS in the U.S.

PI_NAMEs: QI, QIBIN ;SUN, QI  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;anthropogenesis;apolipoprotein C-III;Apolipoprotein E;Apolipoproteins;Blood;blood lipid;blood lipoprotein;Blood specimen;cardiometabolism;Cardiovascular Diseases;cardiovascular health;case control;Cause of Death;Chemicals;cigarette smoking;cohort;Cohort Studies;Collection;Coronary heart disease;cost;Data;Deterioration;Diet;dietary;Dyslipidemias;Environmental Pollutants;Epidemiologist;epidemiology study;ethnic diversity;Ethnic Origin;Etiology;evidence base;excessive weight gain;experience;Exposure to;Follow-Up Studies;Genetic Predisposition to Disease;Goals;Health Professional;heart disease risk;Heterogeneity;High Density Lipoproteins;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Human;improved;Incidence;Individual;innovation;interest;Investigation;Knowledge;LDL Cholesterol Lipoproteins;Link;Lipids;lipoprotein cholesterol;Lipoproteins;Measures;Mediating;Meta-Analysis;Metabolism;Minority;modifiable risk;novel;Nurses' Health Study;Overweight;Participant;particle;Pathway interactions;perfluorooctane sulfonate;perfluorooctanoic acid;Pilot Projects;Policy Making;Poly-fluoroalkyl substances;Population;prevent;Process;Production;prospective;Prospective Studies;Race;Regulation;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Role;sedentary lifestyle;Smoking Behavior;study population;Time

PROJECT_TITLE: Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-K (02)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Genetics;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative  Sickle cell disease and beta-thalassemia are molecular disorders for which few molecular therapies exist. Gene therapy in humans has demonstrated that molecular treatments work, but gene editing/deletion is costly, complicated, and inaccessible. In this project, we will develop chemical biology tools to temporally control a key transcriptional regulator that has been the focus of gene therapy treatments, thereby providing a path to more accessible therapies.

PI_NAMEs: DASSAMA, LAURA  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Ablation;Adult;Affect;Affinity;Alternative Therapies;Anemia;Animals;Antibodies;Antibody Binding Sites;Autologous Transplantation;BCL11A gene;beta Thalassemia;Binding;Biology;bone;Bone Marrow;Bone Marrow Diseases;Cardiac;Caring;Cell membrane;Cell Surface Proteins;cell type;Cells;Chemicals;chronic pain;clinical care;Clinical Trials;Code;conditioning;cost;delivery vehicle;Development;Disease;drug development;Endocytosis;Endosomes;Engineering;Ensure;Erythrocytes;Erythroid Cells;Erythroid Progenitor Cells;Exhibits;FDA approved;fetal;Fetal Hemoglobin;Gene Silencing;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic study;Genetic Transcription;genetically modified cells;Glues;Goals;Hematological Disease;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemoglobin;Hemoglobin concentration result;Human;immunogenic;Impairment;improved;in vivo;Injections;Kinetics;Libraries;Ligands;Lipids;Liver;Lung;Macrophage;man;Mediating;Membrane;Modality;Molecular;Mutation;nanobodies;neuron development;novel therapeutics;Organ;oxygen transport;paralogous gene;Patients;Peptides;Perinatal mortality demographics;Persons;Pharmaceutical Preparations;Pharmacology;Procedures;Production;Program Description;Protac;protein degradation;Protein Fragment;protein phosphatase inhibitor-2;Proteins;Proteome;recruit;Reporting;Research;Role;Scheme;Sickle Cell Anemia;small molecule;Specificity;Spleen;success;Symptoms;System;targeted treatment;Technology;Therapeutic;Tissues;tool;transcription factor;Transcription Repressor;ubiquitin-protein ligase;Vertebral column;Work;Yin

PROJECT_TITLE: Chemical tools for modulating the fetal hemoglobin inducer BCL11A

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This shared instrument grant requests funds for a type of instrument that provides a rapid analysis of multiple characteristics of single cell suspensions. The requested instrument is a type of flow cytometer that can sort cell populations based on their expression of proteins that have been fluorescently tagged. It will be installed in a BSL3 facility where studies are performed on infectious pathogens that cause severe human disease. The requested equipment will empower researchers to enrich specific cell populations to use in subsequent assays in vitro or in vivo, providing critical insights into the function of cell subsets and their interactions in tissues infected with pathogenic viruses.

PI_NAMEs: HABERMAN, ANN M (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Aging;Biological Assay;Biological Sciences;Biomedical Research;biomedical resource;biosafety level 3 facility;Cell Culture Techniques;Cell Separation;Cells;Communicable Diseases;Contract Services;Dedications;Discipline;Equipment;Flow Cytometry;Fluorescence;Funding;Grant;Immune response;In Vitro;Institution;instrument;interest;Modeling;Paper;Phenotype;Process;repaired;Research;Research Personnel;sample fixation;Sampling;single-cell RNA sequencing;Technology;Universities;Vendor

PROJECT_TITLE: Cell sorting flow cytometer for BSL3 research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Involuntary weight gain or weight loss can lead to individuals becoming underweight, overweight, or obese, often indicating an inadequate response to acute health issues or the onset of chronic diseases. To comprehend the underlying causes and develop effective treatments, it is crucial to measure parameters such as energy expenditure and energy intake accurately. This can be achieved through the use of stable isotope tracer technology in combination with isotope ratio mass spectrometry, providing precise measurements for a comprehensive understanding of these phenomena. S10: Isotope Ratio Mass Spectrometer for UW Bioanalytical Isotope Ratio Laboratory

PI_NAMEs: RAVELLI, MICHELE N. (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Address;Advocate;Animals;Area;Biomedical Research;Body Composition;Chronic Disease;Communities;Coupled;Data;Data Reporting;Diet Records;doubly-labeled water;empowerment;energy balance;Energy Intake;Energy Metabolism;Ensure;equipment acquisition;Fostering;Funding;Generations;Goals;Health;Human;Hydrogen;innovation;insight;Institution;instrument;Investigation;Isotopes;Knowledge;Laboratories;Light;Malnutrition;Manufacturer;mass spectrometer;Measurement;Measures;meetings;Metabolic Pathway;Methods;Nutritional Science;Obesity;obesity prevention;operation;Oxygen;Patient Self-Report;Performance;Peripheral;Play;Predisposition;Publications;Questionnaires;repaired;Research;Research Personnel;Role;Sampling;Scientific Advances and Accomplishments;Services;Solid;stable isotope;Technology;United States National Institutes of Health

PROJECT_TITLE: DELTA Q Mass Spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The goal of this grant is to obtain funding to purchase a state-of-the-art image-guided small-animal irradiation device (Precision X-Rad Small Animal Radiation Therapy (SmART)+ Biological Irradiator (Precision X-Ray, Madison, CT) that will allow delivery of x-ray irradiation in a precise and accurate manner to specific tissues of small animals. This will replace our current small-animal irradiator which is nearing the end of its useful lifetime. This device is needed to study radiation biology and therapy in a clinically relevant manner in small animals and is essential to continue the highly productive, NIH-funded research projects that make up our User group.

PI_NAMEs: ROGERS, BUCK E. (contact)

PROJECT_TERMS: Anatomy;Animals;Biological;Biological Process;biological research;Biology;Cancer Biology;Clinical;clinical care;Computers;cone-beam computed tomography;Development;Devices;Disease;Dose Rate;Ensure;Funding;image guided;imaging system;in vivo;Institution;instrument;instrumentation;Location;Magnetic Resonance Imaging;meter;Minor;non-invasive imaging;operation;optical imaging;Photons;Physics;pre-clinical;Pre-Clinical Model;programs;Radiation;radiation delivery;Radiation Oncology;Radiobiology;Research;Research Personnel;Research Project Grants;Resolution;Roentgen Rays;Rotation;Safety;Source;System;Technology;Therapeutic;Therapeutic Intervention;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Purchase of an Image-Guided Small-Animal Irradiator

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: A 400 MHz NMR instrument system equipped with an efficient shielded superconducting magnet, a broadband probe, a 60 slot autosampler and a helium recovery system is proposed to be purchased by Colorado State University. The instrument will be operated and maintained in the University shared use Analytical Resources Core. This instrument provides important data that is used by NIH funded scientists to discover chemical matter used for application in human health such as providing new chemical tools for drug development and biological imaging.

PI_NAMEs: MCNALLY, ANDREW  (contact)

PROJECT_TERMS: Automation;Biological;Biology;Catalysis;Chemicals;Chemistry;Colorado;Computer software;Core Facility;Data Collection;design;Environment;Faculty;Funding;graduate student;Growth;Helium;Home;Image;Institution;instrument;Laboratories;nanoparticle;NMR Spectroscopy;Performance;Pharmaceutical Chemistry;Polymer Chemistry;Postdoctoral Fellow;programs;Recovery;Research;Research Personnel;Research Support;Resolution;Resources;Sampling;Science;Synthesis Chemistry;System;Technology;Time;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A 400MHz NMR Spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE We identified TROP2 as a highly promising and safe therapeutic target for CAR-NK therapy against pancreatic cancer based on extensive preclinical and IND-enabling studies. Here, we propose a Phase I/II clinical trial to test the safety and efficacy of TROP2-targeting CAR-NK cells in pancreatic ductal adenocarcinoma. In addition, we propose to develop the next-generation TROP2-targeting CAR-NK cells by silencing the metabolic checkpoint CREM to further enhance their potency and metabolic fitness.

PI_NAMEs: BASAR, RAFET  (contact);RAFEI, HIND ;REZVANI, KATY

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adoptive Transfer;aerobic glycolysis;Allogenic;Autologous;B lymphoid malignancy;B-Cell Lymphomas;biobank;Biopsy;cancer therapy;CAR T cell therapy;CASP9 gene;CD19 gene;Cell Therapy;Cells;cellular transduction;checkpoint inhibition;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Research;cost;Cryopreservation;Cyclic AMP Response Element;cytokine;Data;Dose;effective therapy;Effector Cell;Endowment;engineered NK cell;Event;Exhibits;FDA approved;first-in-human;fitness;Gene Deletion;Gene Modified;Generations;genetically modified cells;graft vs host disease;Hematologic Neoplasms;human study;immune checkpoint;Immune Targeting;Immunosuppression;improved outcome;In Vitro;in vitro Model;in vivo;innovation;Interleukin-15;intraperitoneal;Lactic acid;Lymphoid Cell;lymphoid neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;manufacturing cost;manufacturing process;Membrane Glycoproteins;Metabolic;metabolic fitness;mouse model;Multiple Myeloma;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;next generation;NK cell therapy;Normal tissue morphology;novel;novel strategies;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;peripheral blood;pharmacologic;Phase I/II Clinical Trial;point of care;Population;pre-clinical;Proliferating;Proteomics;Protocols documentation;Publishing;Reporting;Research;Resistance;response;Retroviral Vector;Safety;safety testing;Secondary to;Signal Transduction;Solid Neoplasm;Specificity;success;Surface Antigens;Survival Rate;T-Lymphocyte;Testing;therapeutic target;Time;Toxic effect;transcription factor;transcriptomics;Translations;trophoblast;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Umbilical Cord Blood

PROJECT_TITLE: TROP2-Directed CAR-NK Cells for the Immunotherapy of Pancreatic Cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Magnetic resonance spectroscopy (MRS) can measure the concentrations of chemicals in the brain. Computer modeling methods extract this information from the measured data, but different methods often deliver different results. This project seeks to develop new tools to capture this variability, to select the most appropriate modeling methods, and to describe the measurement uncertainty of MRS.

PI_NAMEs: OELTZSCHNER, GEORG  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Agreement;Algorithms;Antioxidants;Binding;Biochemical;Biological Markers;Brain;Brain Neoplasms;Cell Proliferation;Chemicals;Clinical;Clinical Research;clinical translation;Clinical Trials;Code;Communities;Computer Models;Computer software;Data;data acquisition;Data Analyses;Data Set;data-driven model;Development;Diagnosis;Disease;Face;Frequencies;Glioma;Goals;Grant;Health;Human;improved;in vivo;in vivo magnetic resonance spectroscopy;Individual;innovation;Isocitrate Dehydrogenase;Lipid Mobilization;macromolecule;Magnetic Resonance Spectroscopy;Markov chain Monte Carlo methodology;Mathematics;Measurement;Measures;Metabolic;Methods;Modeling;Monitor;Mutate;Mutation;Neurons;Neurotransmitters;Noise;novel;open source;Pathology;Patients;Pattern;Pharmaceutical Preparations;Play;Polynomial Models;Procedures;Protons;Qualifying;Reproducibility;Research;response;Role;Sampling;Scanning;Signal Transduction;software development;Surrogate Markers;synthetic data;Techniques;Testing;Time;tool;treatment response;Tumor Markers;Twin Multiple Birth;Uncertainty

PROJECT_TITLE: Model Selection for Magnetic Resonance Spectroscopy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


PHR: Project Narrative: The human body contains a great variety of tissues and cell types, which researchers must study under the microscope in order to understand their functions in health and disease. The requested Orion HT instrument features powerful optical technology that allows it to image up to 20 different color markers in a single automated scan, which will greatly expand our ability to identify multiple cell types within tissues and to visualize their interactions. The instrument will be installed in a core facility at Brigham and Women’s Hospital, where it will support a large community of NIH-funded researchers studying cancer, autoimmunity, inflammation, neurodegeneration and many other disorders.

PI_NAMEs: SANTAGATA, SANDRO  (contact)

PROJECT_TERMS: Algorithms;Antibodies;antibody conjugate;Autoimmunity;Brain;Cell Communication;cell type;Clinical Pathology;Collaborations;Color;Communities;Complex;computerized tools;Core Facility;Data;Data Set;Disease;Fluorescence;fluorescence imaging;fluorophore;Funding;Grant;Heterogeneity;Hospitals;Image;imaging system;Immunofluorescence Immunologic;Individual;Inflammation;Institution;instrument;Label;Lasers;Malignant Neoplasms;Measures;medical schools;Methods;Microscopy;Molecular;multiplexed imaging;Nerve Degeneration;new technology;novel;optical spectra;Research;Research Personnel;Research Support;Resolution;Scanning;Series;Slide;Specimen;Stains;Structure;Technology;Tissue imaging;Tissues;tool;tumor;United States National Institutes of Health;Visualization;Woman

PROJECT_TITLE: Orion: A novel platform for rapid multiplexed tissue imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE More than half of low-income older adults (LOA) have maladaptive fall risk appraisal (a discrepancy between perceived fall risk versus physiological fall risk), which is a known contributor to decreased physical activity and no published study has evaluated interventions to help shift LOA with maladaptive fall risk appraisal to its healthy counterpart—adaptive (realistic) fall risk appraisal. We developed a technology-based, individualized, in-home Physio-fEedback Exercise pRogram (PEER), which includes a) physio-feedback using a real-time portable innovative technology—the BTrackS Balance System; b) cognitive reframing based on a novel fall risk appraisal matrix; and c) peer-led exercise by focusing on balance and strength training. The purposes of this clustered randomized controlled trial study are thus to: 1) examine the effects of the technology-based PEER intervention on fall risk reduction, dynamic balance and accelerometer-based physical activity; 2) examine the effects of the PEER intervention on fall risk appraisal shifting and negative self-perceptions of aging; and 3) explore participants’ experiences with the PEER intervention and potential barriers to access and adoption of the technology-based PEER intervention to inform future research.

PI_NAMEs: THIAMWONG, LADDA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adoption;Aging;arm;Balance training;barrier to care;Categories;Cognitive;Collaborations;Communities;community living;comparison control;Control Groups;cost;Data;disability;Education;Effectiveness;Enrollment;Equilibrium;Exercise;exercise program;experience;Fall prevention;fall risk;falls;fear of falling;Feedback;follow-up;Goals;health organization;healthy aging;Home;home test;Hospitalization;implementation cost;improved;Independent Living;Injury;innovative technologies;Intention;Intervention;intervention effect;intervention program;Interview;Low income;Low Income Population;Mind;mind/body;moderate-to-vigorous physical activity;Motivation;novel;older adult;Outcome Measure;Participant;peer;Perception;Performance;personalized approach;Physical activity;Physiological;Pilot Projects;portability;prevent;Prevention program;programs;Psyche structure;Public Health;Publishing;racial diversity;Randomized, Controlled Trials;Reduce health disparities;Research;Resource-limited setting;Resources;Risk Reduction;Sampling;screening;sedentary;Self Perception;Single-Blind Study;strength training;Structure;System;Technology;technology intervention;technology platform;Time

PROJECT_TITLE: Optimizing a technology-based body and mind intervention to prevent falls and reduce health disparities in low-income populations


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Mitochondrial dysfunction, mitophagy deficits, and the hyperactivity of mitochondria-associated ER membranes (MAM) are early and causative events in the pathogenesis of Alzheimer's disease (AD). The aim of this proposal is to investigate the mechanism underlying the regulation of mitophagy/autophagy and MAM activity by mitochondrial CHCHD10 and to validate the protective role of CHCHD10 antagoNATs in AD pathogenesis in the brains of AD animal model and human neurons.

PI_NAMEs: LIU, TIAN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;abeta deposition;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;amyloid precursor protein processing;Animal Disease Models;APP-PS1;ATP Synthesis Pathway;attenuation;Autophagocytosis;Autophagosome;Behavioral;Binding;Brain;Cell Line;Cells;cohort;Crista ampullaris;Data;Deposition;Disease;DLG4 gene;DNA;Down-Regulation;Early Onset Alzheimer Disease;Endoplasmic Reticulum;Enzymes;Epigenetic Process;Event;Family;Fibroblasts;Functional disorder;Gene Expression;Generations;Genes;Genome Stability;Health;Human;Human Cell Line;Hyperactivity;hyperphosphorylated tau;Impairment;In Vitro;in vivo;insight;Investigation;Lesion;Location;Mediating;Membrane;membrane activity;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Mus;neuroinflammation;Neuronal Plasticity;Neurons;Nonsense Mutation;Nuclear;Oligonucleotides;overexpression;Oxidative Phosphorylation;Parkin;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;PINK1 gene;Play;Process;Production;protective effect;protein expression;Proteins;proteostasis;Reactive Oxygen Species;Recording of previous events;Regulation;Respiration;restoration;Role;secretase;Synapses;Synaptic plasticity;Synaptophysin;tau-1;Testing;Therapeutic;Transcript;Transfection;transgene expression;Wild Type Mouse

PROJECT_TITLE: Protective Role of Mitochondrial CHCHD10 in Alzheimer's Disease through MAM and Mitophagy Mechanisms.

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative As a nationally prominent freestanding medical school, the Medical College of Wisconsin is committed to enhancing and maintaining a regional structural biology resource to support NIH-funded critical research programs in inflammation, infectious diseases, cancer, kidney diseases, diabetes, digestive diseases, and cardiovascular disease. This proposal is to replace an obsolete single-crystal X-ray diffractometer housed at the Medical College of Wisconsin. The new state-of-the-art instrument will enhance the ability of researchers in Southeastern Wisconsin to determine structures of medically relevant proteins, driving biological discoveries and enabling the development of new therapies.

PI_NAMEs: PETERSON, FRANCIS C (contact)

PROJECT_TERMS: 18 year old;Acceleration;Advisory Committees;Anodes;Back;Biochemistry;Biology;Biomedical Research;Biomolecular Nuclear Magnetic Resonance;Chemicals;Collection;Communities;Computers;conflict resolution;Contract Services;Coronavirus;Cryoelectron Microscopy;Crystallization;Crystallography;Cytomegalovirus;Data;drug discovery;Ensure;Equipment;experience;Faculty;Fatty Acids;Funding;Future;human disease;Hybrids;Infrastructure;Institution;instrument;instrumentation;Investments;Ischemia;Liver diseases;Malignant Neoplasms;medical schools;Membrane;Mental disorders;Minor;non-alcoholic;Obesity;Online Systems;operation;Optics;Parkinson Disease;photon-counting detector;programs;Proteins;Recording of previous events;Research Personnel;Resource Sharing;Roentgen Rays;Rotation;Schedule;small molecule;Source;Structural Biologist;structural biology;synergism;System;tenure track;Therapeutic;Time;Training;United States;United States National Institutes of Health;Viral;Wages;Wisconsin;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Synergy-R Diffractometer for Southeastern Wisconsin


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Obesity phenotypes may be useful to guide selection of anti-obesity medications and endoscopic devices to enhance weight loss. Current weight loss lifestyle interventions are not tailored to the physiological and behavioral factors contributing to obesity, and the use of phenotypes to develop long-term lifestyle therapy recommendations for obesity has yet to be investigated. This proposal aims to examine the efficacy of a phenotype-tailored lifestyle intervention therapy for obesity.

PI_NAMEs: ACOSTA, ANDRES J (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;adult obesity;Anxiety;attenuation;Bariatrics;Behavior;Behavior Therapy;Behavioral;behavioral phenotyping;biomarker performance;Blinded;Body mass index;Body Weight Changes;Body Weight decreased;Calories;Chronic;Classification;clinical application;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;cohort;comparison intervention;Consumption;Counseling;Data;design;Devices;Diet;Disease;Eating;efficacy evaluation;emotional eating;Emotions;Endoscopy;energy balance;Energy Metabolism;evidence base;Functional disorder;Gastric Emptying;gastrointestinal;genetic variant;Goals;group intervention;Homeostasis;Hormones;Hour;Hunger;improved;individualized medicine;industry partner;Interval training;intervention program;Life Style;lifestyle intervention;Lifestyle Therapy;Long-Term Effects;Machine Learning;Maintenance;Methods;Names;novel marker;obese patients;Obesity;Obesity Epidemic;obesity treatment;Outcome;Participant;Pathogenesis;Patients;personalized approach;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Physiological;predicting response;predictive marker;preservation;Prevalence;Procedures;Prospective cohort;Proteins;Publishing;Radiation exposure;Radioisotopes;Randomized;randomized trial;randomized, clinical trials;Recommendation;Relapse;Reporting;Research;response;Rest;Rewards;Satiation;Supplementation;Testing;therapy design;Thinness;Time;trait;Validation;weight loss intervention;weight loss program

PROJECT_TITLE: Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE The proposed study will address the physiological importance of a tissue-to-tissue communication between the hypothalamus and white adipose tissue (WAT) in the regulation of aging and longevity in mammals. We have recently identified a specific subpopulation of neurons in a region called the dorsomedial hypothalamus (DMH). These specific neurons control WAT function, while WAT controls the activity of those neurons. The strength of this interesting feedback loop wanes over time, but why and how this feedback loop wanes over time remains unknown. In this research proposal, we will address this question and analyze how the functions of the DMH neurons and WAT deteriorate. The anticipated outcome of this study will advance our understanding of the systemic regulation of mammalian aging and longevity and provide a new possibility to develop an effective anti-aging intervention based on this critical tissue-to-tissue communication between the hypothalamus and WAT.

PI_NAMEs: IMAI, SHIN-ICHIRO  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Affect;Age;age related;aged;Aging;anti aging;Applications Grants;Cell Aging;Cell Nucleus;Cell Physiology;Cells;Communication;Cyclic GMP-Dependent Protein Kinases;Cytoplasm;Death Rate;Deterioration;Enzymes;extend lifespan;extracellular;extracellular vesicles;Feedback;Functional disorder;Genes;Genetic;Hypothalamic structure;Immune;Intervention;life span;Lipolysis;Longevity;Lymphoid Cell;Mammals;Mediating;MicroRNAs;model organism;Mus;Nervous System Physiology;Neurons;Niacinamide;Norepinephrine;old mice;Outcome;Outcome Study;Phenotype;Physiological;Play;Population;Regulation;Reporting;Research;Research Proposals;Role;Running;senescence associated secretory phenotype;senescent cell;Signal Transduction;Sympathetic Nervous System;Time;Tissues;Transplantation;Visceral

PROJECT_TITLE: The intertissue communication between the hypothalamus and adipose tissue for mammalian aging and longevity control

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Traumatic brain injury (TBI) is considered the “signature” injury of the recent US wartime conflicts, with approximately 15% of warfighters experiencing single or multiple mild TBIs (mTBI). PTSD is a frequent comorbidity in this population, with almost 35% of mTBI exposed Veterans reporting qualifying symptoms associated with their service in theater. The presenting symptomatology of PTSD (i.e., emotion dysregulation and cognitive deficits) may have an underlying basis in the biomechanical disruption by TBI of brain regions underlying emotional processing and memory. This same disruption may interfere with effective treatment. Animal models are necessary in order to unravel the effect of TBI on the brain circuitry underlying PTSD. We will therefore utilize high density electrophysiology (recordings) and stimulation in awake behaving rats and pigs to elucidate how TBI affects the circuitry underlying PTSD, the acquisition and extinction of PTSD-like behavioral phenotypes, and to develop a new neuromodulatory treatment for this co-morbidity.

PI_NAMEs: WOLF, JOHN ALLEN (contact)

PROJECT_TERMS: Affect;Amygdaloid structure;Animal Model;associated symptom;awake;Axon;axon injury;behavioral outcome;behavioral phenotyping;Biomechanics;brain circuitry;Brain region;Chronic;Clinical;Cognition;Cognitive deficits;cognitive function;cognitive task;cognitive testing;Communication;comorbidity;conditioned fear;Coupling;Data;Deep Brain Stimulation;density;Development;Diffuse;Diffuse Axonal Injury;Disabling;effective therapy;Electric Stimulation;Electrophysiology (science);emotion dysregulation;Emotional;Equilibrium;experience;Extinction;Failure;Family suidae;fear memory;forgetting;Fright;Functional disorder;Goals;Hippocampus;Human;Impaired cognition;improved;injured;Injury;insight;Intervention;Learning;Limbic System;Memory;mild traumatic brain injury;Modality;Modeling;Nerve Degeneration;network dysfunction;neural;neural circuit;neural network;neuromechanism;Neurons;neuropathology;neurophysiology;neuroregulation;Output;overexpression;Pathway interactions;Phase;Physiological;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Property;Qualifying;rational design;Rattus;Reporting;Research;response;Rodent;Role;Services;Site;Structure;symptomatology;System;targeted treatment;Testing;Time;Traumatic Brain Injury;Veterans;warfighter

PROJECT_TITLE: Neuromodulation as a Therapy for PTSD following Chronic TBI

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The Jackson Laboratory, in partnership with community college faculty across the state of Connecticut, proposes to develop a curriculum program to improve genetics and genomics literacy among community college students preparing to enter the biomedical research workforce. By targeting students training for entry-level professions and by developing online content modules, we seek to train a broad and diverse audience. Our content modules will expand students’ understanding of how human genomics intersects with healthcare, ultimately strengthening the future STEM workforce.

PI_NAMEs: BARTER, WILLIAM ;WOJISKI, SARAH  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adoption;animation;Area;Back;Biomedical Research;Biotechnology;Capital;career;Career Choice;college;Communities;community college;Connecticut;Country;curriculum development;design;Development;digital;direct application;Discipline of Nursing;Disparity population;E-learning;Education;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;effectiveness evaluation;Employment;Enrollment;ethical, legal, and social implication;Evaluation;Faculty;faculty community;Financial Support;Funding Opportunities;Future;Genetic;genetic testing;Genomic approach;Genomic medicine;genomic variation;Genomics;Goals;Health;health literacy;Healthcare;Hispanic-serving Institution;Human;human disease;human genomics;improved;Individual;Infrastructure;innovation;Institution;interactive multimedia;interest;Knowledge;Laboratories;Learning;Learning Module;Life;Link;literacy;Medical;Minority Groups;minority student;Minority-Serving Institution;National Human Genome Research Institute;Occupations;Participant;peer;personalized medicine;Positioning Attribute;programs;real world application;Research;Resources;response;Role;Science;Science, Technology, Engineering and Mathematics Education;skills;STEM career;Strategic vision;student training;Students;Surveys;System;Teacher Professional Development;The Jackson Laboratory;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;university student;uptake;usability;virtual;workforce needs;Workplace

PROJECT_TITLE: Genomics in Action

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J2)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE We are requesting funds for a QPatch II-48 automated patch clamp system, designed for acquiring high-fidelity patch clamp data at medium to high-throughput. The design of the QPatch II recording plates allows patch clamping of cell types not commonly used with automated patch clamp systems, such as primary immune cells and iPSC-derived neurons or cardiomyocytes. There is currently no such system available at NYU or within New York City. High-fidelity patch clamp recordings using this instrument will allow us to gain insight into the roles of ion channels across disciplines (pathology, cardiology, immunology and neuroscience) and will facilitate translational research at NYUGSOM and the NYU College of Dentistry in Lower Manhattan.

PI_NAMEs: SONG, SOOMIN CHRISTOPHER (contact)

PROJECT_TERMS: Basic Science;Businesses;Calcium;Cardiology;Cells;college;Contract Services;cost;Data;Dentistry;design;Electrophysiology (science);Enhancers;experience;Floor;Fluorides;Funding;Immune;Immunology;Individual;induced pluripotent stem cell derived cardiomyocytes;Institution;instrument;interest;Location;Maintenance;medical schools;Names;Neurons;Neurosciences;New York City;patch clamp;Pathology;Research Personnel;Research Support;Reservations;Science;seal;System;Time;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Automated Patch Clamp System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative This proposal develops `micro-capsule' technology to enable high-throughput screening and systematic mapping of cell-cell interactions, which are central to many diseases. The new tools developed here will significantly accelerate our ability to both gain quantitative insights into how cells interact with one another in health and disease, and to enable new platforms for therapeutic discovery of proteins that change cell signaling.

PI_NAMEs: KLEIN, ALLON MOSHE (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acceleration;Affinity;Agonist;antagonist;Antibodies;Bacteria;Behavior;Benchmarking;Biochemical;Biological Assay;biological research;capsule;Cell Adhesion;cell capsule;Cell Communication;cell fixation;cell growth;Cell Surface Receptors;cell type;Cells;Chemistry;cost;Cultured Cells;cytokine;Data;design;Development;digital;Disease;DNA;DNA Sequence;Elasticity;Environment;Enzymes;Evolution;Future;Goals;Grant;Health;high throughput analysis;high throughput screening;high throughput technology;Hydrogels;Image;Immune;insight;interest;Ions;Libraries;Ligands;Liquid substance;Maps;Methods;Microcapsules drug delivery system;Microfluidic Microchips;microfluidic technology;Microfluidics;Nanostructures;new technology;Organoids;Output;Peptides;Performance;Permeability;Polymers;Problem Solving;Property;Protein Secretion;Proteins;prototype;Rapid screening;receptor;Reporter;Reproducibility;Research;resilience;response;RNA;screening;Signal Transduction;single cell genomics;single molecule;small molecule;Solid;Sorting;Specificity;Stains;Structure;Surface;System;Technology;Testing;Therapeutic;Thinness;Time;tool;Validation;Variant

PROJECT_TITLE: Micro-capsule technology for high-throughput analyses of cell-cell interactions

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: Project Narrative The proposed work aims to elucidate the diverse set of activities employed by a class of viral proteins when degrading cellular factors to subvert the host’s immune defenses and enhance viral infectivity. The information obtained from this work will facilitate the design of new antiviral inhibitors for use in therapeutic control of HIV and other virus infections.

PI_NAMEs: XIONG, YONG  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: 3-Dimensional;Binding;Biochemical;Biophysics;Capsid Proteins;CD4 Positive T Lymphocytes;Cell Cycle Arrest;cellular targeting;Classification;cofactor;combat;Communities;Comparative Study;Complex;Cryoelectron Microscopy;Cyclophilin A;Cytidine Deaminase;Deamination;Degradation Pathway;design;Evolution;experimental study;factor A;Fluorescence;Goals;HIV;HIV-1;Host Defense Mechanism;Immune;Immune system;In Vitro;in vivo;Infection;inhibitor;insight;Integration Host Factors;Invaded;Knowledge;Mammals;Mediating;Methods;Molecular;multicatalytic endopeptidase complex;Mutagenesis;novel therapeutics;pathogen;Pathway interactions;Peptidylprolyl Isomerase;Phosphoric Monoester Hydrolases;PPP2R5A gene;Primate Lentiviruses;Protein Family;Protein Isoforms;Protein phosphatase;Proteins;reconstruction;recruit;Research;Research Design;Research Project Grants;Resolution;Reverse Transcription;Sheep;Spectrum Analysis;structural biology;Structure;System;Techniques;Therapeutic;tool;Transcript;transcription factor;Ubiquitin;ubiquitin-protein ligase;Validation;Viral;Viral Physiology;Viral Proteins;Virion;Virus Diseases;Virus Inhibitors;Virus Replication;Visna-maedi virus;Work;X-Ray Crystallography

PROJECT_TITLE: Multifaceted interactions between lentiviral Vif and host molecules for viral infectivity enhancement

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Fibrolamellar hepatocellular carcinoma (FLC) is a rare cancer of children and young adults that has no standard or effective treatment options. The overall goal of our project is to study a novel cancer treatment that targets the unique metabolism of FLC tumors, in combination with other treatments that work on the human immune system. We will test this treatment approach in FLC patients and also learn about the mechanisms of response with this approach using tumors from the patients as well as preclinical models.

PI_NAMEs: YARCHOAN, MARK  (contact)

PROJECT_TERMS: Acidosis;addiction;Adult;Affect;Amino Acids;Ammonia;antagonist;anti-PD-L1;anti-tumor immune response;Antimetabolites;Biological Markers;Biopsy;Biopsy Specimen;Blood;cancer therapy;Catalytic Domain;Cell Line;Cell Physiology;Child;Chimera organism;Cirrhosis;Clinical;Clinical Trials;Critical Pathways;Cyclic AMP-Dependent Protein Kinases;Cytometry;Data;Dependence;effective therapy;effector T cell;Evaluation;Event;Exons;Fibrolamellar Hepatocellular Carcinoma;Functional disorder;Generations;genomic signature;Glutamine;Goals;Hexosamines;Human;Image;Immune;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immune response;Immune system;Immunity;Immunosuppression;Immunotherapy;Impairment;in vivo;in vivo Model;Infiltration;Learning;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Molecular;mouse model;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;nucleotide metabolism;Nutrient Depletion;objective response rate;Oncogenic;Pathway interactions;Patients;PDL1 inhibitors;peripheral blood;pharmacologic;Phosphotransferases;Population;pre-clinical;Pre-Clinical Model;Primary Malignant Neoplasm of Liver;Prior Therapy;PRKACA gene;Process;Prodrugs;Production;Prognosis;Protein Inhibition;Proteins;Purines;rare cancer;Refractory;response;safety testing;Serum;Signal Transduction;small molecule inhibitor;Solid Neoplasm;standard care;Systemic Therapy;T cell response;T-Lymphocyte;Testing;Therapeutic Effect;Toxic effect;Transcript;transcriptome;Translating;treatment effect;tumor;Tumor Immunity;tumor microenvironment;Tumor-Associated Process;tumor-immune system interactions;Vaccines;Work;young adult

PROJECT_TITLE: Exploiting A Critical Vulnerability To Glutamine Antimetabolite Therapy in Fibrolamellar Hepatocellular Carcinoma (FLC)

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  This proposal offers ungated, quantitative myocardial perfusion magnetic resonance imaging for atrial fibrillation (AFIB) patients. The new data acquisition and processing methods will allow for improved identification and quantification of the amount of myocardial tissue at risk in patients with AFIB and coronary artery disease. Accurate identification of the myocardial tissue at risk helps in their treatment management.

PI_NAMEs: ADLURU, GANESH  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acceleration;Affect;American;Anatomy;Angiography;Area;Atrial Fibrillation;Benchmarking;Blood flow;Bolus Infusion;Breathing;Cardiac;cardiac magnetic resonance imaging;Clinical;Compensation;computerized data processing;Coronary;Coronary Arteriosclerosis;cost;cost estimate;Data;data acquisition;deep learning;Defect;Detection;Diagnostic;diagnostic accuracy;diagnostic tool;disease diagnosis;Electrocardiogram;Epidemic;Evaluation;Exclusion;experience;Healthcare;Healthcare Systems;Heart;heart motion;hemodynamics;Image;imaging modality;improved;Institution;Ionizing radiation;Ischemia;learning network;Lesion;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;millisecond;Modality;Motion;Myocardial;Myocardial perfusion;Myocardial tissue;Myocardium;novel;patient prognosis;patient subsets;Patients;Performance;Perfusion;perfusion imaging;Perfusion Weighted MRI;Phase;Pilot Projects;Positron-Emission Tomography;Protocols documentation;quantitative imaging;Radial;radiotracer;rapid technique;reconstruction;Regional Perfusion;Resolution;Risk;ROC Curve;Sampling;Scanning;Sensitivity and Specificity;Signal Transduction;single photon emission computed tomography;Slice;Specificity;success;Techniques;Technology;Time;tool;Visual;Vulnerable Populations;X-Ray Computed Tomography

PROJECT_TITLE: Improved detection of coronary artery disease in atrial fibrillation patients using ungated perfusion MRI methods

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Homeostatic plasticity stabilizes neural function throughout the lifespan. We will establish how failure of homeostatic plasticity contributes to the pathophysiology of a novel mouse model of Jordan’s syndrome, associated with severe intellectual disability.

PI_NAMEs: DAVIS, GRAEME W (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 3-Dimensional;Adult;Alleles;Antisense Technology;autism spectrum disorder;autosomal dominant mutation;Biochemical;Brain;Brain Diseases;Clinical;Data;Defect;design;Development;Drosophila genus;Electron Microscopy;Electrophysiology (science);Epilepsy;Etiology;experimental study;Failure;Functional disorder;Future;Genes;Genetic;Genetic Screening;Heterozygote;Hippocampus;Holoenzymes;Human;Impairment;insight;Integrin beta Chains;Integrins;Intellectual functioning disability;Jordan;Knock-out;Knockout Mice;Laboratories;life span;Link;loss of function;Mediating;Mental disorders;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Nervous System Disorder;Neurodevelopmental Disorder;neuronal excitability;Neurophysiology - biologic function;Neurotransmitter Receptor;neurotransmitter release;novel;novel therapeutic intervention;Pathology;Phenotype;Phosphoric Monoester Hydrolases;Physiological;Physiological Processes;postsynaptic;PPP2R5D gene;presynaptic;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;reconstruction;Regulation;Research;restoration;Rodent;severe intellectual disability;Severities;Signal Transduction;Structure;Synapses;Synaptic Transmission;Syndrome;System;Therapeutic

PROJECT_TITLE: Homeostatic plasticity in mouse models of Jordan's Syndrome

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: The Isothermal Titration Calorimeter will allow us to measure how well two molecules fit together. This information is of fundamental importance to many scientific projects at the University of Montana that seek to understand how the human body works at the molecular level and design new strategies and molecules for treating disease.

PI_NAMEs: HUGHES, TRAVIS SHANE (contact)

PROJECT_TERMS: Adverse effects;Affect;Affinity;Algorithms;Area;Bacteria;Binding;Binding Sites;Borrelia burgdorferi;cofactor;Communities;Data;design;Drug Receptors;enthalpy;Entropy;Family;Fluorescence;Fluorescence Anisotropy;Funding;genetic information;Health;instrument;Label;Ligands;Lyme Disease;Measurement;Measures;Mediating;Methods;Minor;Modeling;Molecular Conformation;Montana;Mus;mutant;Mutation;next generation;Nuclear Receptors;Pharmaceutical Preparations;Prevalence;Probability;Protein Conformation;Proteins;receptor binding;Research;RNA;RNA Binding;Surface;Surface Plasmon Resonance;Temperature;Testing;Titrations;transcription factor;United States National Institutes of Health;Universities;Water;Work

PROJECT_TITLE: Isothermal Titration Calorimeter


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Prevention;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The proposed study is relevant to public health as it examines the mechanistic-basis of calcific aortic stenosis; a prevalent disease observed in up to 35% of the population, including children suffering the congenital aortic valve malformation, Bicuspid Aortic Valve disease. The planned research has the potential to improve patient outcome by understanding the contributions to disease pathogenesis that can be used to improve early diagnosis and better predict those at risk.

PI_NAMEs: LADISA, JOHN FRANK;LINCOLN, JOY  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Accounting;Address;Adolescent;Affect;Age;Aorta;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;bicuspid aortic valve;Biomechanics;Birth;Blood flow;calcification;Calcium;Cardiac;Cessation of life;Child;Clinical;Clinical Management;cohort;Computer Models;Data;Deposition;Development;Diagnostic;Disease;Early Diagnosis;Early identification;early onset;effective therapy;Elderly;Endothelial Cells;Endothelium;Exhibits;Exposure to;Functional disorder;Gene Expression;Genes;Heart Valve Diseases;high risk;high risk population;Human;human model;improved;insight;interstitial cell;Intervention;Lead;Left;Liquid substance;malformation;Mechanics;mechanotransduction;Methods;molecular phenotype;mortality;mouse model;Mus;novel;Obstruction;old mice;Onset of illness;Operative Surgical Procedures;osteogenic;Outcome;outcome prediction;Outcome Study;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Periodicals;Phenotype;Population;premature;prevent;Procedures;Process;Production;programs;Public Health;Purinoceptor;receptor;Recommendation;Reporting;Research;Risk;Risk Assessment;Risk Factors;Severities;shear stress;Signal Pathway;Signal Transduction;simulation;stem;Stenosis;Stress;Structure;Surface;Symptoms;Testing;Therapeutic;therapeutic target;Time;transcriptomics;treatment strategy;young adult

PROJECT_TITLE: Bicuspid Aortic Valve Biomechanics and Calcification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-R (02)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Allergic diseases afflict 40% of the United States population, but it is unknown how allergens activate dendritic cells which are required for the initiation of allergic immune responses. A research program will be undertaken to study the neuroimmune interactions that endow sensory neurons with the ability to detect allergens, and how sensory neurons and dendritic cells interact to promote the activation of the allergic immune response. These studies will provide fundamental basic immunological insights into how allergic disease is initiated and will lay the foundation to develop novel therapeutic strategies to prevent and treat allergic diseases.

PI_NAMEs: SOKOL, CAROLINE LAUREN (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: adaptive immune response;Afferent Neurons;Allergens;Allergic;Allergic Disease;Antigens;B-Lymphocytes;Bacteria;Basophils;CCR8 gene;Cell Communication;Cell Maturation;cell motility;Cell Physiology;Cells;Cellular Immunology;Cellular Neurobiology;chronic itch;Cutaneous;Data;Dendritic cell activation;Dendritic Cells;Dermal;Dermis;Detection;Development;Disease;draining lymph node;Endowment;environmental allergen;experience;Foundations;fungus;Gene Modified;Goals;Health;IgE;Immune;immune activation;Immune response;Immune system;Immunity;Immunization;Immunologics;improved;In Vitro;in vivo;Innate Immune Response;Innate Immune System;insight;Interleukin-4;Laboratories;Licensing;Lymphoid Cell;mast cell;migration;Mus;Nervous System;Neuroimmune;Neurons;Neuropeptides;neurotransmitter release;novel;novel therapeutic intervention;novel therapeutics;pain sensation;Papain;Papaya;Pathway interactions;Patients;Peptide Hydrolases;Play;Population;Prevalence;prevent;Production;programs;Pruritus;release factor;Research;response;Role;sensor;Sensory;Signal Transduction;Skin;Substance P;T-Lymphocyte;Testing;Th2 Cells;therapeutic development;tool;TRPV1 gene;United States;Venoms

PROJECT_TITLE: Neuroimmune Control of Allergic Immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: KANSAS CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Since 2011, the Kansas University Medical Center's Genomics Core has supported sequencing experiments directed at understanding the genetic basis of disease for more than 200 investigators across 27 states and 45 institutions. Acquiring an Illumina NovaSeq X Plus Sequencing System will provide higher quality data, faster turnaround, improved data output, and significantly reduced costs for our Major and Minor users who currently hold over $87M in total NIH funding aimed at improving human health.

PI_NAMEs: SMITH, PETER G (contact)

PROJECT_TERMS: Alzheimer's Disease;Award;base;Bioinformatics;Cancer Center;Cells;Centers of Research Excellence;Chromium;Clinical Research;cost;Coupled;Data Analyses;data management;data quality;Development;Disadvantaged;DNA;DNA Sequencing Facility;Ensure;frontier;Funding;Future;Gene Chips;Genomics;Grant;Health;improved;Infrastructure;Institution;instrument;Kansas;Library Automation;Medical center;Midwestern United States;Minor;Mission;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;next generation sequencing;operation;Polycystic Kidney Diseases;programs;quality assurance;Research;Research Personnel;robotic system;Savings;Services;Synthesis Chemistry;System;Technology;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: NovaSeq X Plus Sequencing System


NIH_SPENDING_CATS: Coronaviruses

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE Founded in 2010, the Human Immune Profiling Consortium (HIPC) has successfully brought together independent research centers to identify immune signatures associated with the outcomes of vaccinations and infections in humans. We propose to develop a HIPC Coordinating Center (HCC) that supports the HIPC network by providing a centralized Portal and Knowledgebase to facilitate data analysis and visualization, and to promote collaborations across the network by organizing subcommittees and cross-HIPC analysis projects.

PI_NAMEs: KLEINSTEIN, STEVEN H.;PETERS, BJOERN  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adopted;Area;Awareness;base;Biological Assay;centralized portal;Clinical;clinical phenotype;Clinical Research;Collaborations;Communication;Communities;Conflict of Interest;Coupled;Data;Data Analyses;Data Coordinating Center;data portal;data sharing;data standards;data visualization;Decision Making;Dedications;Development;Ensure;Expenditure;experience;FAIR principles;Familiarity;Fostering;Funding;Funding Opportunities;Grant;Human;Human Activities;Human Characteristics;Immune;Immune response;Immunology;improved;Infection;Infrastructure;Institution;International;Investments;Knowledge;knowledgebase;Lead;Learning;Life;Measures;meetings;Methods;Modeling;National Institute of Allergy and Infectious Disease;operation;organizational structure;outreach program;Procedures;Process;programs;promoter;Publications;Reporting;Request for Applications;Research;Running;social media;Standardization;success;System;Teleconferences;Time;timeline;tool;Twitter;Update;Vaccination;vaccination outcome;Visualization;web site;Work

PROJECT_TITLE: HIPC Data Coordinating Center


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Genetics;Human Genome

ORG_DEPT: GENETICS

PHR: Project Narrative Genetics and genomics are expanding into biomedical research and healthcare, so it is essential that all levels of the research and clinical workforce have some knowledge regarding these topics to ensure that this expansion is done in an inclusive and ethical way. Given the relatively high prevalence of many genetic conditions (e.g., familial hypercholesterolemia, breast cancer, sickle cell disease, etc.), establishing a knowledge-base for the wide applicability of genetics and genomics to the general public will facilitate integration of these topics into research to benefit health outcomes. We will create and freely share genomics learning modules (GEMs) enabling entry-level training and certificate programs to add genetics and genomics education to their curricula so that their graduates will be able to use, apply and disseminate this knowledge.

PI_NAMEs: APPLEGATE, CAROLYN D (contact)

PROJECT_TERMS: Adult;Advisory Committees;animation;Area;Attention;Baltimore;Biology;Biomedical Research;Cardiovascular system;certificate program;Child Health;Cities;Clinical;Collaborations;Communities;community college;Community Health Aides;cost;County;Dedications;demographics;design;Discipline;E-learning;Education;Educational Curriculum;Educational Models;Educational Status;Enrollment;Equity;Ethics;experience;Faculty;Familial Hypercholesterolemia;Feedback;Funding;General Population;Genetic;Genetic Diseases;Genomics;Goals;Health Benefit;health inequalities;Healthcare;High Prevalence;improved;Inequity;instructor;International;Journals;Knowledge;knowledgebase;Laboratories;laboratory curriculum;Lead;Learning;Learning Module;lectures;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;medical specialties;Medicine;meetings;neonatal health;Occupations;online delivery;Outcome;Pamphlets;Participant;Patient Self-Report;Professional Organizations;Program Development;programs;Protocols documentation;Public Health;Publishing;Reproductive Health;Research;responsible research conduct;Role;Science;Sickle Cell Anemia;Site;skills;Slide;social media;Students;Surveys;theories;Training;Training Programs;Trust;Underserved Population;United States National Institutes of Health;Variant;web site;Work;Workforce Development;workforce needs

PROJECT_TITLE: Education Modules to Boost DiveRsity And InCrease Equity in Genomics (EMBRACE Genomics)


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Illumination of many biomolecules produces a characteristic optical signature. These signatures provide valuable information on the three-dimensional structure of the biomolecule, including how structural changes enable biomolecular function, and how mutations or other modifications affect function. Purchase of the proposed instrument will enable University of Notre Dame researchers to measure these optical signatures as part of a broader effort to understand the molecular details of a wide variety of biological processes, including protein folding and aggregation, bacterial pathogenesis, and cancer mechanisms.

PI_NAMEs: CLARK, PATRICIA LOUISE (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Binding;Biological Process;biophysical tools;Biophysics;Caring;Catalysis;catalyst;Chemicals;Circular Dichroism;Circular Dichroism Spectroscopy;Computers;Core Facility;design;Detection;Development;Employment;Equipment;Fluorescence;Fluorescent Dyes;Funding;Goals;improved;Inferior;instrument;instrumentation;life span;Ligands;Maintenance;Modernization;Molecular;Molecular Structure;NIH Program Announcements;Nitrogen;Nucleic Acids;Optical Instrument;Optics;Pharmaceutical Preparations;Productivity;Property;Protein Conformation;Proteins;purge;Research;Research Infrastructure;response;Scientist;small molecule;Structure;Supervision;Techniques;Temperature;Universities

PROJECT_TITLE: Upgraded circular dichroism spectropolarimeter for Notre Dame Biophysics Instrumentation Core Facility


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: SAINT JOSEPH MERCY HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project, to increase NCI clinical trials capacity, within the Michigan Cancer Research Consortium (MCRC)-National Community Oncology Research Program, will be the first to be completed by a Clinician Scientist (Elie Dib, MD, MS, FACP) who works with patients and families in a community setting. Nationally, the majority of cancer care is delivered in the community setting, making it essential to have representation from this type of research leader. Outside of MCRC, significant impact will also be felt by the Alliance Research Base and NCI, due to Dr. Dib’s deep contributions to clinical trials protocols, committees, and initiatives focused on immuno-oncology, precision oncology, and prevention and symptom intervention.

PI_NAMEs: DIB, ELIE G (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Academic Medical Centers;Adopted;anti-cancer research;Area;base;Cancer Biology;cancer care;Caring;clinical trial enrollment;clinical trial protocol;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Community Healthcare;community setting;Development;Educational process of instructing;Enrollment;experience;Faculty;Family;Funding;Genomics;Health;Health system;Hospitals;Immunooncology;improved;Intervention;Joint Ventures;Knowledge;Lead;lecturer;Medical Oncologist;Medicine;member;Michigan;Minority Groups;Oncologist;Oncology;patient population;patient screening;Patients;phase I trial;precision oncology;Prevention;Productivity;programs;Protocols documentation;Qualifying;Research;Research Personnel;Safety;Scientist;Site;skills;Symptoms;Therapeutic;Time;tool;Underserved Population;Universities;Urogenital Cancer;Work

PROJECT_TITLE: Research Capacity Building by a Clinician Scientist within the Michigan Cancer Research Consortium- National Community Oncology Research Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J1)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Nutrition;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE  Although pancreatic ductal adenocarcinoma (PDAC) can alter the mRNA translation efficiency (mTE) of codons in response to severe nutrient-depleted environments to selectively synthesize proteins required for adaptation and tumorigenesis, we still do not understand the pathways that regulate this process in human cancers. This proposal aims to decipher the signaling cascades and mechanisms that regulate the mRNA translation efficiencies of Ser codons upon Ser-starvation, and to target these pathways during PDAC tumorigenesis. The findings from this work will have a profound impact on our fundamental understanding of the pathways and mechanisms that regulate the mTE of Ser codons, identify a therapeutic vulnerability in the adaptation to Ser-starvation in PDAC, and can greatly shift our perception of the effects of codon regulatory pathways in human health and disease.

PI_NAMEs: BANH, ROBERT SINGHUNG (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Amino Acids;beta-2 Microglobulin;biochemical model;Biological Assay;Biological Models;Biology;Breast;Cancer Patient;Candidate Disease Gene;Cell Cycle;Cell Cycle Arrest;Cell surface;Cells;Charge;Codon Nucleotides;Complex;CRISPR screen;Cyclin-Dependent Kinases;deprivation;Diet;dietary;dietary restriction;Disease;Environment;Enzymes;Genes;Genetic Diseases;Genetic Transcription;Glycine;Growth;Health;Human;Human Genetics;Hypoxia;Immune;Immunocompetent;immunodeficiency;Immunofluorescence Immunologic;Impairment;improved outcome;Initiator Codon;insight;Intellectual functioning disability;Intervention;KPC model;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Malignant Neoplasms;Measures;Melanoma;molecular modeling;mouse model;mRNA Translation;Mus;mutant;Mutation;Nerve;Nerve Growth Factors;nerve supply;novel therapeutic intervention;novel therapeutics;Nuclear;Nutrient;Nutrient Depletion;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Perception;Perfusion;Phosphorylation;preference;prevent;Process;Production;Prognosis;Protein Biosynthesis;Proteins;Proteome;Proteomics;Regulation;Regulatory Pathway;Reporter;Research;Resistance;response;ribosome profiling;Role;Serine;serine-tRNA;Signal Pathway;Signal Transduction;Spatial Distribution;Starvation;Therapeutic;Transfer RNA;Translation Initiation;tRNA Precursor;tumor;tumor ablation;Tumor Burden;tumorigenesis;Western Blotting;whole genome;Work

PROJECT_TITLE: Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The proposed UHPLC-MS/MS instrumentation will provide our lab with much needed bioanalytical capacity and capability to aid in our quest to discover the molecular underpinnings of human disease in the pediatric patient. Our lab supports basic and clinical researchers working in the fields of microbiology, microbiome, and infectious disease, childhood obesity, inflammatory disorders (MIS-C in COVID-19 Infection) and gastroenterology and hepatology disorders – the basic and clinical research that we support has a direct impact on the lives of the patients that we serve.

PI_NAMEs: HORVATH, THOMAS DONALD (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Basic Science;Cardiology;Child;Childhood;Clinical Research;Consumption;Discipline of obstetrics;Funding;Gastroenterology;Growth;Gynecology;Hepatology;High Pressure Liquid Chromatography;Hospital Departments;Hybrids;innovation;instrument;instrumentation;Laboratories;Marketing;mass spectrometer;Mass Spectrum Analysis;Medical center;Medicine;metabolomics;microbiome;Nephrology;nutrition;Patient Care;Pediatric Hospitals;pediatric patients;Pediatrics;Proteomics;Research Personnel;Sampling;Series;small molecule;System;tandem mass spectrometry;Texas;Translational Research;translational research program;United States National Institutes of Health

PROJECT_TITLE: ACQUISITION OF A QTRAP 7500 HYBRID QQQ/LIT MASS SPECTROMETER FOR PEDIATRIC TRANSLATIONAL RESEARCH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE: High Throughput Screening (HTS) employs advanced automation to test very large and diverse compound libraries for finding novel chemical modulators that serve as the basis for early-stage drug discovery. HTS workflow architecture must orchestrate the use of multiple instrumental components (i.e., dispensers, incubators, plate readers…) in concert with one another to complete parallel screens in support of an HTS drug discovery campaign. Requested are replacement dispensers that automate the bulk reagent dispensation into assay plates since the present units are obsolete having reached “End of Support” for equipment hardware and software operating systems.

PI_NAMEs: SCAMPAVIA, LOUIS DANIEL (contact)

PROJECT_TERMS: Architecture;Basic Science;Biological Assay;Buffers;Cells;Communicable Diseases;Communities;Computer software;Detection;Devices;Drops;drug discovery;Drug Screening;Engineering;Ensure;Faculty;Florida;Funding;Future;Generations;high throughput screening;Informatics;innovation;instrument;Interruption;loss of function;miniaturize;Operating System;operation;Preparation;programs;Proteins;Reagent;Research;Research Institute;screening;Security;Services;Source;System;Technology;Time;Translational Research;United States National Institutes of Health;Virus Diseases

PROJECT_TITLE: BioRaptr Replacement Dispensers to Support High Throughput Screening


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative: The differentiation process of lung alveolar epithelial type 2 (AT2) cells into alveolar epithelial type 1 (AT1) cells plays an essential role in the repair and regeneration of alveolar epithelium following injury. Therefore, it is important to gain insights into the mechanisms governing this cellular differentiation. This project aims to explore the mechanistic role of mitochondrial calcium uptake in regulating metabolic dynamics, which influence chromatin structure and gene expression during the transition from AT2 to AT1 cells.

PI_NAMEs: TIAN, YING  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Affect;Aging;alpha ketoglutarate;alveolar epithelium;Bacterial Pneumonia;Biological Models;Biology;Calcium;Cell Differentiation process;Cells;Chromatin Structure;chronic respiratory disease;Citric Acid Cycle;clinically relevant;Cytoplasm;Defect;demethylation;design;Development;Effector Cell;Elderly;Epigenetic Process;epithelial repair;epithelium regeneration;feeding;Gene Expression;Genes;Genome;Glutaminase;Histone H3;histone methylation;histone modification;Histones;Homeostasis;inhibitor;Injury;insight;Link;Lung;lung injury;lung repair;Lysine;Mediating;Metabolic;Metabolism;metabolomics;Methylation;Mitochondria;Mitochondrial Matrix;Molecular;mouse model;multidisciplinary;mutant mouse model;Natural regeneration;novel therapeutic intervention;Oxidoreductase;pharmacologic;Play;Population;Process;Production;programs;Proliferating;Psychological reinforcement;Reaction;repaired;Role;scaffold;Signal Transduction;stem cells;Succinates;Supplementation;Testing;Therapeutic;therapeutically effective;tissue regeneration;Tissues;uptake

PROJECT_TITLE: Elucidating the contribution of mitochondrial calcium uptake to lung epithelial regeneration

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative State-of-the-Art Preclinical PET/CT Imaging System Yale University PET Center This proposal aims to provide a state-of-the-art preclinical imaging instrument for combined Positron Emission Tomography (PET) and Computed Tomography (CT) research studies. PET/CT imaging is used to detect and quantify biochemical processes and physiological functions in the living body across broad applications of oncology, cardiology, psychiatry, neurology, metabolic disorders, and inflammation. Addition of a new preclinical PET/CT system to replace an end-of-life PET-only system will allow us to leverage the Center's expertise in radiochemistry and quantitative PET imaging to support exciting research studying new mechanisms for the diagnosis and therapy of human disease.

PI_NAMEs: NORMANDIN, MARC DAVID (contact)

PROJECT_TERMS: Area;Biochemical Process;Biological;biomedical imaging;Birds;Canis familiaris;Cardiac;Cardiology;Characteristics;Core Facility;Data;Dedications;Development;Diagnosis;end of life;Exhibits;Funding;Goals;high resolution imaging;Human;human disease;Image;imaging system;improved;Inflammation;instrument;instrumentation;Internal Medicine;Measurement;Metabolic Diseases;Methods;Motion;Mus;Neurology;Neurosciences;nonhuman primate;novel;Oncology;Oryctolagus cuniculus;Physiological;Positron-Emission Tomography;pre-clinical;preclinical imaging;Psychiatry;Public Health;radiological imaging;Radiopharmaceuticals;Rattus;Research;Research Personnel;research study;Resolution;respiratory;Speed;System;Tracer;United States National Institutes of Health;Universities;whole body imaging;X-Ray Computed Tomography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE This research will explain how societal stressors experienced from early childhood into young adulthood affect Latinx youth’s mental health. Using an integrated data analysis approach, investigators will pool data from five longitudinal Latinx cohort studies spanning 2010-2026 to follow 2,515 Latinx youth and mothers from youth’s age 2 to 22. Knowledge about Latinx youth’s mental health trajectories within a context of societal stressors and modifiable family stress processes and adaptive factors will inform effective Latinx mental health interventions.

PI_NAMEs: CALZADA, ESTHER J;CAUGHY, MARGARET O;ROCHE, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Address;Affect;Age;Anxiety;biological sex;Censuses;Characteristics;Child;Child Rearing;Cohort Studies;cost effective;course development;COVID-19;COVID-19 pandemic;Data;Data Aggregation;Data Analyses;data integration;Data Pooling;Data Set;Depressed mood;Development;Distal;early childhood;early experience;Early identification;Economics;Equation;ethnic discrimination;ethnic identity;Ethnic Origin;Event;experience;Exposure to;Family;Feeling hopeless;Goals;Health;Heterogeneity;High School Student;Immigrant;Immigration;Individual;Informal Social Control;Intervention;Knowledge;Latinx;Latinx population;Life Cycle Stages;life span;Light;Link;Longitudinal cohort study;marginalization;marginalized population;maternal depression;Measurement;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Modeling;Mothers;multilevel analysis;National Institute of Mental Health;National origin;Nature;Neighborhoods;pandemic disease;Parents;Pathway interactions;Perception;Policies;Population;preventive intervention;Process;Race;Recording of previous events;Reporting;Research;Research Personnel;response;Sampling;sex;Shapes;Signal Transduction;social;Social Problems;Socialization;sociodemographics;socioeconomic disadvantage;Strategic Planning;Stress;stress management;stressor;Surgeon;Surveys;Symptoms;theories;Twitter;young adult;Youth

PROJECT_TITLE: Societal stressors, adaptive factors, and developmental timing: Influences on Latinx mental health from early childhood through young adulthood

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases;Pediatric

ORG_STATE: MA

PHR: Neutrophils are immune cells that are critical for containing and clearing an infection, yet they have the capacity to damage tissue and contribute to microclot formation if over activated. Neutrophils may play an important role in pathogenesis of Long COVID. Here, we aim to define neutrophil phenotypes with single-cell RNA sequencing and test neutrophil functionality and contributions to microclot formation in order to define the role of the neutrophil in pediatric Long COVID. Our goal is to unveil novel strategies for diagnosing and treating Long COVID with the goal of improving health outcomes in these children.

PI_NAMEs: YONKER, LAEL  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Adult;Affect;antagonist;Antigen-Antibody Complex;Antigens;Automobile Driving;Biological Assay;Blood;Blood Platelets;Blood Vessels;Cells;Cessation of life;chemokine;Chest Pain;Child;Childhood;Circulation;Clinical Treatment;Clinical Trials;Coagulation Process;COVID-19 patient;Diagnosis;Diagnostic;Disease;Dyspnea;effective therapy;Employment;Fatigue;Funding;Future;gastrointestinal;Gene Cluster;Gene Expression;Gene Expression Profile;Gene set enrichment analysis;Goals;Health;Health Care Costs;Immune;Immunoglobulin A;improved;In Vitro;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Intervention;Intestinal permeability;Link;Measures;Microfluidics;migration;Mucous Membrane;Multisystem Inflammatory Syndrome in Children;neutrophil;Neutrophil Activation;novel strategies;Orthostatic tachycardia;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Performance;Permeability;Phagocytosis;Phenotype;Plasma;Play;Population;post-COVID-19;programs;Proteins;Proteomics;receptor;Reporting;Role;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;Schools;single-cell RNA sequencing;Source;Stomach;Subgroup;Symptoms;Syndrome;Technology;Testing;Therapeutic;Tissues;transcriptome sequencing;zonulin

PROJECT_TITLE: Defining neutrophil pathobiology in pediatric Long COVID

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: To reduce the high toll of global deaths and morbidity caused by infectious diseases, we will generate and use new kinds of information about disease causing organisms. We will perform genomic, transcriptomic and functional research on viral, bacterial, fungal, and vector-borne pathogens under a Genomic Center for Infectious Diseases to identify new threats and targets for treatment, inform clinical treatment of disease, and support public health initiatives to monitor and respond effectively to infectious diseases outbreaks.

PI_NAMEs: BIRREN, BRUCE W.;NEAFSEY, DANIEL E (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Antimicrobial Resistance;Arboviruses;bacterial resistance;base editing;Biological Models;burden of illness;Candida auris;carbapenem resistance;Cessation of life;Chromosome Mapping;Clinical;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;collaborative approach;combat;Communicable Diseases;Communities;CRISPR interference;Cryptococcus neoformans;Data;design;Diagnostic;Disease;Disease Outbreaks;Ebola;effective intervention;efficacious intervention;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;empowerment;Epidemic;experience;filaria;gene function;Generations;Genetic Variation;Genomic approach;Genomic Centers for Infectious Diseases;genomic data;genomic epidemiology;Genomics;Guyana;Human;Immune;improved;Infectious disease threat;Infectious Diseases Research;innovation;Intervention;invention;Knowledge;Malaria;malaria infection;Measures;Metagenomics;Methods;microbial genomics;Molecular;Monitor;Morbidity - disease rate;Neisseria gonorrhoeae;novel;Organism;pandemic disease;Parasitic Diseases;pathogen;Patients;Pharmaceutical Preparations;Phenotype;Plasmids;Population;Population Surveillance;Practice Management;pressure;priority pathogen;Pseudomonas aeruginosa;Public Health;Records;Research;Research Personnel;Research Project Grants;Resistance;resistance factors;resistance gene;response;Sampling;Scientist;single-cell RNA sequencing;Societies;spillover event;synergism;System;Technology;technology development;Testing;Therapeutic;therapeutic target;Time;tool;transcriptomics;transmission process;Vaccines;vector;vector-borne pathogen;Vector-transmitted infectious disease;Viral;viral epidemic;viral outbreak;Virulence;virulence gene;virus genetics;ZIKA

PROJECT_TITLE: Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MFH-M (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Social Determinants of Health

PI_NAMEs: NEAFSEY, DANIEL E (contact)

PROJECT_TERMS: Address;Bioinformatics;broadening participation research;Collaborations;collaborative approach;combat;Communicable Diseases;Communication;Communities;Community Health;Complex;Computer Analysis;cost efficient;Data;data management;data sharing;Disease Outbreaks;Education and Outreach;Educational workshop;Emergency response;Emerging Communicable Diseases;emerging pathogen;Ensure;Epidemic;Exclusion;experience;flexibility;Future;genome sciences;Genomic Centers for Infectious Diseases;Genomics;Goals;improved;Individual;Industry;Infectious Diseases Research;innovation;Laboratories;Leadership;marginalization;marginalized community;meetings;member;Methods;minority undergraduate;Mission;Monitor;National Institute of Allergy and Infectious Disease;organizational structure;outreach;outreach program;Performance;Pilot Projects;Practice Management;Process;programs;Public Health;public health priorities;Reporting;Research;Research Project Grants;Research Support;Research Training;Resources;Scientist;Services;Site Visit;success;Technology;technology research and development;Teleconferences;timeline;Training;transcriptomics;Visit;Work

PROJECT_TITLE: Admin Core: integrating innovative genomic science for infectious disease


PI_NAMEs: PARK, DANIEL JOHN (contact)

PROJECT_TERMS: Address;Algorithms;Bacteria;bioinformatics pipeline;Biology;Cells;Cloud Computing;combat;Communicable Diseases;Communities;cost;Cost efficiency;Data;data management;data sharing;design;Diagnostic;emerging pathogen;empowerment;experience;Fee-for-Service Plans;Fungal Genes;fungus;Gene Expression;gene function;Generations;Genomic approach;genomic data;Genomics;Graph;Health;High-Throughput Nucleotide Sequencing;Human;Hybrids;improved;Infectious Diseases Research;Infrastructure;innovation;insight;Institution;Laboratories;Libraries;Machine Learning;Methodology;Methods;microbial;Mission;novel;Nucleic Acids;pan-genome;Parasites;Physiological Adaptation;portability;Positioning Attribute;Protocols documentation;Publishing;Research;Research Personnel;Resolution;Resources;Sampling;scale up;Scientific Advances and Accomplishments;Services;Signal Transduction;single-cell RNA sequencing;System;technological innovation;Technology;Time;Tissues;tool;transcriptome sequencing;transcriptomics;variant detection;vector;Virus;Work

PROJECT_TITLE: Technology and Data Core: enabling innovative data generation and analytics for infectious disease research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: SABETI, PARDIS CHRISTINE (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African;analytical method;analytical tool;Bayesian Method;Biological Assay;Circulation;Clinical;combat;Communicable Diseases;Community Health;cost;COVID-19 pandemic;Data;Data Set;design;Detection;Development;Diagnostic;diagnostic assay;Disease;Disease Outbreaks;disease transmission;Ebola;emerging pathogen;Environment;epidemic potential;Epidemiology;Etiology;Evolution;experience;Future;future outbreak;Genetic Variation;genome resource;genome sciences;genomic data;genomic epidemiology;Genomics;Genotype;Goals;Human;human disease;Immune system;immunogenicity;improved;In Vitro;innovation;insight;Intervention;Knowledge;Machine Learning;metagenomic sequencing;Metagenomics;Methods;Modeling;Mutation;novel diagnostics;Outcome;pathogen;pathogen genomics;Phenotype;Phylogenetic Analysis;Policies;Population Genetics;Public Health;Public Health Practice;Recording of previous events;Research;Resources;Sampling;Signal Transduction;Societies;Speed;Therapeutic;tool;transcriptomics;Translating;transmission process;Vaccine Design;vaccine efficacy;Vaccines;vector;Viral;viral detection;viral epidemic;viral fitness;Viral Genome;viral genomics;viral outbreak;viral transmission;Virus;Virus Diseases;virus genetics;Work

PROJECT_TITLE: Viral genomics: comprehensive detection, transmission inference, and functional characterization


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections

PI_NAMEs: EARL, ASHLEE MIRIAM (contact)

PROJECT_TERMS: Algorithm Design;Anatomy;Antibiotic Resistance;Antibiotics;Antibody Repertoire;Antigens;Attention;Automobile Driving;Bacterial Infections;Bacterial RNA;Bioinformatics;carbapenem resistance;carbapenem resistant Enterobacterales;carbapenemase;Cells;Chronic;Clinical;Clinical Data;cohort;Collaborations;Collection;combat;Communicable Diseases;Communities;Computational algorithm;computerized tools;Computing Methodologies;Data;data framework;data integration;data resource;Data Set;Development;Diagnosis;differential expression;DNA;Drug resistance;emerging pathogen;empowerment;Environment;Epidemiology;Frequencies;Future;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Gonorrhea;Graph;Health;Heterogeneity;Horizontal Gene Transfer;Human;Hybrids;Hydrolysis;Immune;Immune response;Immune system;Immunity;improved;Individual;Infection;Infection Control;innovation;insight;Intervention;Investigation;Knowledge;Length;Measures;Mediating;Medical;Methodology;Methods;Molecular;molecular diagnostics;mucosal site;multidisciplinary;multiple omics;Neisseria gonorrhoeae;novel;Nursing Homes;Outcome;pan-genome;pathogen;pathogenic bacteria;Patients;Persons;Phase;Plasmids;Play;Population;Positioning Attribute;pressure;prevent;Prophylactic treatment;Protocols documentation;Pseudomonas;Pseudomonas aeruginosa;Public Health;reproductive organ;Research;Resistance;resistance factors;resistance gene;resistance mechanism;response;RNA;Role;Route;Sampling;Sepsis;Serum;Site;Specimen;Techniques;Technology;Testing;Therapeutic Intervention;Time;tool;transcriptome;transcriptome sequencing;transcriptomics;transmission process;vaccine development;Variant;VDAC1 gene;Virulence;Virulence Factors;virulence gene

PROJECT_TITLE: Bacterial genomics: multiscale investigation of host adaptation, unexplained resistance and plasmid dynamics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: CUOMO, CHRISTINA A (contact)

PROJECT_TERMS: Address;Animal Model;anti-fungal agents;Antifungal Therapy;Atlases;Bar Codes;Biological;Biology;brain tissue;Candida;Candida auris;capsule;Cells;Chromosome Mapping;Classification;Clinical;Clinical Research;cohort;combat;CRISPR interference;Cryptococcus;Cryptococcus neoformans;Data;Development;Disease Outbreaks;Disease Progression;Distant;Drug Exposure;Drug resistance;Drug Targeting;Drug usage;effective therapy;emerging pathogen;Environment;Essential Genes;Exhibits;experimental study;Exposure to;Fungal Drug Resistance;fungus;Gene Expression;gene function;Genes;Genetic;Genetic study;Genetic Transcription;Genome;genome wide association study;Genomic approach;genomic data;Genomic Segment;Genomics;Genotype;Goals;Granuloma;Growth;Health;Heterogeneity;High temperature of physical object;Human;Immune response;Immunocompromised Host;In Vitro;Individual;Infection;Intervention;knock-down;Laboratories;Libraries;Lung;Lung infections;Maps;Measures;Metadata;Methods;Monitor;mortality;Multi-Drug Resistance;Mus;new technology;pathogen;Pathogenesis;pathogenic fungus;Pharmacotherapy;Phenotype;phenotypic data;Population;Property;Reporting;Repression;Resistance;response;Sampling;Sepsis;Severities;Severity of illness;single cell sequencing;single-cell RNA sequencing;Sodium Chloride;Stress;Structure of parenchyma of lung;synergism;System;Technology;Temperature;Testing;tool;Transcript;transcriptomics;treatment strategy;Variant;Virulence;Virulent;whole genome;Work;World Health Organization

PROJECT_TITLE: Fungal genomics: population and systematic studies to map determinants of virulence, unique biology, and drug resistance


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Aedes;Americas;Arboviruses;Arthropod Vectors;authority;Award;Awareness;base editing;Biological;Biological Assay;Biology;CD147 antigen;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collaborations;combat;Country;Culex (Genus);Culicidae;Data Collection;data integration;Detection;Development;Diagnosis;Disease;disease transmission;drug sensitivity;efficacy study;emerging pathogen;Engineering;epidemiologic data;Epidemiology;Erythrocytes;Evaluation;experience;filaria;Filarial Elephantiases;Future;Genetic;Genetic Polymorphism;Genomic approach;Genomic Centers for Infectious Diseases;genomic data;genomic epidemiology;Genomics;Goals;Guatemala;Guyana;Health;Honduras;Human;human migration;Infection;innovation;Intervention;Invaded;Libraries;Ligands;Localized Disease;Malaria;malaria infection;malaria transmission;Maps;Measures;Mesoamerican;metagenomic sequencing;Methodology;Molecular;new therapeutic target;novel;novel virus;Panama;parasite genome;parasite invasion;Parasites;pathogen;Peptides;Phage Display;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium vivax;Population;pressure;Prevalence;prevent;protective effect;Proteome;receptor;Research Personnel;Residual state;Salivary Glands;Salivary Proteins;Sampling;seropositive;serosurvey;South American;Specimen;Surveys;Testing;therapeutic development;therapeutic target;therapy development;Time;tool;transcriptomics;transmission process;vaccine efficacy;Vaccines;vector;vector-borne pathogen;Vector-transmitted infectious disease;Vertebrate Viruses;Viral;Viral Vector;Virus;Work;World Health Organization;ZIKA

PROJECT_TITLE: Parasite and vector genomics: advancing intervention development, disease elimination strategy, and elimination campaign evaluation


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SHREVEPORT

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE Changes in endothelial cell function, which are the main lining layer of cells within the vessel wall, occur secondary to disturbed arterial blood flow, resulting in a process called endothelial to mesenchymal transition (EndMT). In severe atherosclerosis, and its subsequent clinical complications, such as heart attack, EndMT plays a fundamental role by promoting inflammation, yet the mechanism of EndMT formation secondary to disturbed blood flow is largely unknown. Our research identifies the interleukin-1 receptor activated kinase (IRAK1) as a novel regulator in d-flow-induced EndMT and understanding the mechanism whereby IRAK1 alters endothelial function may provide novel therapeutic targets to limit atherosclerosis and its complications in patients with heart diseases.

PI_NAMEs: ALFAIDI, MABRUKA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acute myocardial infarction;Anti-Inflammatory Agents;Antibodies;Arterial Fatty Streak;Atherosclerosis;Blood;Blood flow;Blood Vessels;Bypass;Cardiovascular system;CCL2 gene;Cell Physiology;cell type;Cells;Cessation of life;Clinical;clinically relevant;Coronary Arteriosclerosis;CRISPR/Cas technology;cytokine;Data;Death Rate;Development;Diet;Disease;disorder risk;Endothelial Cells;Endothelium;feeding;Gene Silencing;Genes;genome wide association study;Heart Diseases;Human;human disease;IL8 gene;Immune;Immune response;Immunoprecipitation;Immunosuppression;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Interleukin Activation;Interleukin-1;Interleukin-1 beta;Interleukin-1 Receptors;Interleukin-6;IRAK1 gene;IRAK4 gene;Knockout Mice;Knowledge;Lesion;Leukocytes;Ligation;Link;Lipids;Maps;Mass Spectrum Analysis;Measures;Mediating;Mesenchymal;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myocardial Infarction;new therapeutic target;novel;Outcome Study;overexpression;Pathogenesis;Patients;percutaneous coronary intervention;Phenotype;Phosphotransferases;plaque lesion;Play;prevent;Process;Protein Kinase;Publishing;Quality of life;Receptor Signaling;recruit;Research;response;Role;Rupture;Scaffolding Protein;Secondary to;Severity of illness;Signal Pathway;Signal Transduction;Site;Sudden Death;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Thick;Thrombosis;transcription factor;transcriptome sequencing;Transfection;treatment strategy;vector;western diet;White Blood Cell Count procedure;Work

PROJECT_TITLE: IL-1R1 in Endothelial-to-Mesenchymal Activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (02)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: DURHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Temporomandibular disorder (TMD), characterized by mechanical pain and masticatory allodynia, is the most common form of orofacial pain and negatively impact patients’ quality of life. In this project, we aim to identify and validate if and how LPA/LPAR signaling contributes to TMD pain. Success of this project may open new doors for development of safe and effective methods to prevent and treat TMD pain.

PI_NAMEs: CHEN, YONG  (contact);NACKLEY, ANDREA G

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: addiction liability;Afferent Neurons;allodynia;Anatomy;Animal Model;animal pain;animal tissue;Anterior;Attenuated;Chronic;chronic painful condition;Clinical;clinically relevant;clinically significant;conditional knockout;Connective Tissue;Data;Development;Electrophysiology (science);Etiology;experimental study;Freund's Adjuvant;Goals;Human;human tissue;Injury;Ion Channel;joint inflammation;Joints;Knock-out;Laboratories;Ligation;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Masseter Muscle;Masticatory muscles;mechanical drive;mechanical stimulus;Mechanics;Mediating;Methods;mouse model;multidisciplinary;Mus;Neurons;novel;Oral cavity;Orofacial Pain;Pain;Pain intensity;Pain Measurement;pain reduction;painful neuropathy;Patients;pharmacologic;Pharmacotherapy;Piezo 2 ion channel;Plasma;prevent;Quality of life;receptor;receptor expression;Receptor Signaling;response;Safety;sex;side effect;Signal Transduction;Structure of trigeminal ganglion;success;Synovial Fluid;Temporomandibular Joint;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Tendon structure;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;TMD treatment;Transducers;Translations;Validation;Work

PROJECT_TITLE: Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Z (55)]