ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Lupus;Microbiome

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Intestinal pathobionts can exacerbate lupus pathogenesis; however, how the immune system mediates their pathogenic effects remains unknown. The proposed research will use mouse models to identify how the peripheral expansion of thymic pathobiont-specific T cells mediate bacterial exacerbation of lupus pathogenesis. These studies will increase our understanding in host-microbe interactions in the context of autoimmunity, which will improve therapeutic and prophylactic approaches for patients with lupus.

PI_NAMEs: ZEGARRA RUIZ, DANIEL FERNANDO (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: adaptive immune response;Adult;antigen-specific T cells;Antigens;Attention;Autoantigens;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Bacteria;Bacterial Translocation;career;career development;Cell Differentiation process;Cells;Chronic;Communication;Data;design;Development;Disease;disease model;Disease Progression;Doctor of Philosophy;dysbiosis;effector T cell;Ensure;Exhibits;Foundations;Generations;Goals;graduate school;Growth;gut inflammation;gut microbes;gut microbiota;host-microbe interactions;Immune response;Immune system;immunodeficiency;Immunology;improved;Individual;Inflammation;Inflammatory;innate immune pathways;Intestinal permeability;Intestines;Knowledge;Laboratories;Lactobacillus reuteri;Learning;Link;Liver;Lupus;lupus prone mice;Mediating;Memorial Sloan-Kettering Cancer Center;Mentors;mesenteric lymph node;microbial colonization;microbiota;Modeling;mouse model;Mus;Organ;pathobiont;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;post-doctoral training;Postdoctoral Fellow;Predisposition;Process;Production;programs;prophylactic;Regulation;Research;research and development;Research Institute;Research Personnel;Research Support;response;Role;Site;skills;Spleen;Supervision;synergism;systemic inflammatory response;Systemic Lupus Erythematosus;T cell response;T-Cell Development;T-Lymphocyte;Technical Expertise;Techniques;Testing;Therapeutic;Thymus Gland;Tissues;Training;Weaning;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of lupus pathogenesis through modulation of thymic development of pathobiont-specific T cells

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE A model has emerged showing that ectopic lipid accumulation is associated with loss of stem cell maintenance and tissue homeostasis with age. Elucidating mechanisms regulating ectopic lipid accumulation in stem cell niches will aid in the development of new strategies targeting stem cell-based regenerative therapies.

PI_NAMEs: DEMARCO, RAFAEL S (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Adult;adult stem cell;Affect;Age;age related;age related changes;age related decline;aged;Aging;Anabolism;Binding Proteins;Biological Models;cancer cell;Catabolism;cell age;cell behavior;Cell Count;Cell Maintenance;Cell Physiology;cell type;Cells;Cues;Data;Development;dietary;Dietary Supplementation;Drosophila genus;Drosophila melanogaster;Elements;Environment;Equilibrium;Experimental Designs;Family;Fatty Acids;fly;Functional disorder;Gene Expression;Generations;Genetic;genetic manipulation;germline stem cells;Goals;Homeostasis;Homologous Gene;Laboratories;Levocarnitine;Life;life span;lipid metabolism;Lipids;loss of function;Maintenance;male;Mediating;Metabolic;metabolic abnormality assessment;Metabolism;Mitochondria;Modeling;Molecular;Older Population;Organ;Pathway interactions;Play;Population;prevent;Process;Publishing;regenerative therapy;Regulation;Regulatory Element;Research;Research Assistant;Role;self-renewal;Signal Transduction;Sirolimus;Snails;stem;stem cell biology;stem cell function;stem cell niche;stem cell population;stem cells;Sterols;Supporting Cell;System;Testing;Testis;tissue regeneration;Tissues;tool;transcription factor;undergraduate research;undergraduate student;Universities;Work

PROJECT_TITLE: Metabolic regulation of the stem cell niche

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The cell-surface glypican Dally-like protein (Dlp) interacts with several secreted Wnts to modulate their extracellular availability for signaling, which is critical for tissue development and homeostasis; and aberrant Wnt availability and signaling are linked with tumorigenesis. In this proposal, I will integrate powerful genetic tools available in Drosophila with biochemical, proteomic, and imaging approaches to investigate how Dlp-mediated regulation of Wnt signaling is affected by proteolytic cleavage of Dlp my Matrix Metalloprotease2 (Mmp2) in developmental and tumorigenic contexts. Additionally, I will investigate previously unappreciated roles of Dlp in Wnt ligand production, availability, and signaling.

PI_NAMEs: WAGHMARE, INDRAYANI  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Actins;Adhesions;Affect;Behavior;Binding;Biochemical;Cancer cell line;Carcinoma;Cell Adhesion;cell behavior;Cell Proliferation;Cell Shape;Cell surface;cell type;Cells;Communication;Complex;Cytoskeleton;Data;Development;Distant;Drosophila genus;Ensure;Epithelium;Event;extracellular;Extracellular Space;fly;Genetic;Glypican;Growth;Homeostasis;imaging approach;Integral Membrane Protein;Investigation;Ligands;Link;Matrix Metalloproteinases;Mediating;Metalloproteases;migration;Modeling;Molecular;novel;Oogenesis;Organism;Output;paracrine;Paracrine Communication;Pathway interactions;Pattern;Phase;Production;Proteins;Proteolysis;Proteomics;Regulation;Reporting;Role;Signal Transduction;Source;Testing;Tissues;tool;tumor;tumor growth;Tumor Promotion;tumorigenesis;tumorigenic;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: Mechanisms of Wg/Wnt regulation by glypican Dlp


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: TULSA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TULSA

ORG_STATE: OK

PHR: The proposed research is relevant to human health because centrosome defects are associated with diseases such as primary microcephaly and cancer. Developing therapeutic or preventative interventions for any disease begins with gaining a fundamental understanding of disease-associated pathways at the level of basic science. Thus, the proposed research is relevant to the NIH’s mission of pursuing fundamental knowledge to reduce the burdens of illness.

PI_NAMEs: IYER, JYOTI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Basic Science;Biogenesis;Biological;Biological Models;Biology;burden of illness;Caenorhabditis elegans;Cells;Cellular biology;Centrioles;Centrosome;Chromosomes;Cilia;Clathrin;Clathrin Heavy Chains;Collaborations;Core Protein;Data;Daughter;Defect;Development;Disease;Dynamin;Endocytic Vesicle;Endocytosis;Ensure;Fracture;Functional disorder;Genetic;Goals;Health;Homeostasis;Human;Hybrids;Impairment;in vivo;in vivo Model;innovation;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;Membrane Proteins;Microcephaly;Microtubules;Mission;Mitotic spindle;Molecular;Molecular Biology Techniques;Mothers;Organelles;Pathway interactions;Phenocopy;Phosphotransferases;Play;preventive intervention;Process;protein transport;Proteins;recruit;Regulation;Research;Role;Testing;Therapeutic Intervention;trafficking;Training;undergraduate student;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Role of Vesicular Trafficking Proteins in Regulating Centrosomes


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative: The G-protein receptor GPR39 regulates zinc-based dyshomeostasis, a key marker of neurodegeneration of Alzheimer’s disease (AD). Positron Emission Tomography (PET) radiotracers that can image real-time GPR39 levels in AD brains are urgently needed to advance our understanding of the altered regulations and inform the development of new, effective AD therapeutics.

PI_NAMEs: SOLINGAPURAM SAI, KIRAN  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta oligomer;Active Sites;AD transgenic mice;Affect;Age;Agonist;alcohol use disorder;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animals;Anxiety Disorders;APP-PS1;Autopsy;Autoradiography;behavioral study;Binding;Biochemical Process;Biodistribution;Biological Assay;Brain;Brain region;brain tissue;Clinical;Cognitive;cognitive function;cognitive performance;Coupled;Data;Decision Making;Deposition;design;Development;Dissociation;Dose;Down-Regulation;Drug Kinetics;excitotoxicity;experience;Future;G-Protein-Coupled Receptors;GPR39 gene;GTP-Binding Proteins;Health;High Pressure Liquid Chromatography;Homeostasis;Human;hyperphosphorylated tau;Image;Imaging Device;imaging potential;imaging study;Impairment;improved;in vivo;in vivo imaging;Kinetics;Knock-out;Lead;Learning;Measures;Mediating;Memory;Mental Depression;Metabolic;Methods;Microtubules;Moods;mouse model;multidisciplinary;Mus;Nerve Degeneration;neuroinflammation;Neuronal Plasticity;Neurons;neuropathology;neuroprotection;neurotransmission;novel;novel therapeutics;Outcome;overexpression;Oxidative Stress;Pathogenesis;Pathway interactions;Penetration;Persons;Pharmaceutical Preparations;pharmacologic;Plasma;Positron-Emission Tomography;Property;protein expression;Protocols documentation;Pyrrolidines;radioligand;radiotracer;real-time images;receptor;Regulation;Reporting;Research;Rodent;Rodent Model;Role;sex;Signal Transduction;Specificity;Structure;Symptoms;tau-1;Techniques;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;tool;Transgenic Mice;Transgenic Organisms;uptake;Vascular Dementia;Vascular Diseases;Western Blotting;Wild Type Mouse;X-Ray Computed Tomography;Zinc

PROJECT_TITLE: Developing novel PET radioligands to image GPR39 in Alzheimer's Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: JACKSONVILLE

ORG_NAME: NEMOURS CHILDREN'S CLINIC

ORG_STATE: FL

PHR: Project Narrative We propose an observational study to be conducted as part of a new network of clinical centers and a coordinating center to be assembled, to further explore the impact of type 1 diabetes (T1D) on the brain in young children of racial/ethnic and socioeconomic diversity, studied shortly after the diagnosis of T1D, compared to age-matched nondiabetic controls. We will use sophisticated neurocognitive assessments, structural and functional brain imaging, psychosocial questionaries, social determinants of health and glucose data, as children get insulinized for the first time and many are transitioned by their providers to advanced insulin delivery (closed- loop) systems over 2-years. These studies will provide critical insight as to whether earlier intervention aimed to near-normalize blood glucose could have a positive impact in cognitive outcomes in children, an area of great contemporary importance.

PI_NAMEs: MAURAS, NELLY  (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 10 year old;4 year old;Age;Area;Artificial Endocrine Pancreas;Back;Bicarbonates;Biometry;Blood;Blood Glucose;Brain;brain behavior;Brain imaging;brain magnetic resonance imaging;Brain region;brain volume;Child;Clinical;clinical center;clinical infrastructure;Cognitive;cognitive function;cognitive task;cohort;Collection;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Development;diabetes control;diabetes distress;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diffusion;Early Intervention;ethnic discrimination;ethnic minority;Ethnic Origin;executive function;experience;Family;Food;Fright;Functional Magnetic Resonance Imaging;Funding Opportunities;Glucose;glucose sensor;glycemic control;Glycosylated hemoglobin A;gray matter;health data;Health Services Accessibility;Health Technology;Housing;Hyperglycemia;Hypoglycemia;improved;innovation;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Internet;Latino;Longitudinal, observational study;low socioeconomic status;Magnetic Resonance Imaging;Measures;Memory;Metabolic;Metabolic Control;Moods;Multicenter Studies;Multimodal Imaging;Neurocognitive;neurocognitive test;non-diabetic;Not Hispanic or Latino;Observational Study;Outcome;Oxygen;Parents;patient population;Patients;Perception;Performance;PhenX Toolkit;prepuberty;prevent;primary outcome;Principal Investigator;protective factors;prototype;Provider;psychosocial;Psychosocial Assessment and Care;Publishing;Quality of life;Questionnaires;Race;racial discrimination;racial diversity;racial minority;recruit;Reporting;Research;Research Design;Research Infrastructure;Rest;Risk Factors;Severities;sex;Short-Term Memory;Siblings;social health determinants;socioeconomic diversity;socioeconomics;Standardization;Structure;System;Technology;Testing;Time;United States National Institutes of Health;verbal;white matter;Work

PROJECT_TITLE: Cognitive, structural and functional impact of new onset type 1 diabetes on the brain of young children: Understanding risks and protective factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Prevention;Rare Diseases;Rehabilitation;Vaginal Cancer;Women's Health Research

ORG_CITY: CORVALLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Despite the high prevalence of sexual health concerns in cancer survivorship, these concerns often go unaddressed. This project is expected to prepare our team for the successful launch of a multisite pragmatic trial to evaluate whether the virtual Mindful After Cancer intervention can be integrated into routine cancer and improve sexual health outcomes for breast and gynecological cancer survivors. This can make a significant contribution toward improving equity in access to comprehensive sexual health services and reducing the burden of cancer for this population.

PI_NAMEs: GORMAN, JESSICA LYNN RICKARD (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Administrator;Adoption;Advocate;Affect;Attention;Body Image;Cancer Burden;cancer care;Cancer Intervention;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;care providers;Clinical;clinical practice;Communities;community based care;contextual factors;Data;Data Collection;data infrastructure;design;Dissemination and Implementation;Distress;effectiveness evaluation;effectiveness testing;Equity;Evaluation;Evidence based intervention;experience;Feasibility Studies;Foundations;Future;future implementation;General Population;Goals;Health;health care service;Health Services;High Prevalence;implementation intervention;improved;Individual;informant;Infrastructure;interest;Intervention;intervention delivery;Interview;intimate behavior;Knowledge;Life;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Methodology;Methods;mindfulness;mindfulness intervention;novel;Numbness;Oregon;Outcome;Pain;Patients;Persons;pilot trial;Population;pragmatic trial;Preparation;primary outcome;Procedures;Process;Protocols documentation;psychologic;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resources;retention rate;routine practice;Sampling;satisfaction;Self Efficacy;service delivery;Sex Functioning;Sexual Health;sexual health intervention;Shapes;Site;social;Supervision;Testing;Training;Translating;Translations;trial planning;Vagina;virtual;virtual delivery;Woman;Work

PROJECT_TITLE: Virtual Mindful After Cancer Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative The brain can alter skeletal muscle metabolism, increasing calories burned by prompting the muscle to generate heat, a process called thermogenesis. We have shown that exposing animals like rats and mice to the odor of a predator triggers muscle thermogenesis, and that this involves activation of a brain region that is important in both metabolic regulation and determining how an animal responds to predators. Here, we probe the role of a cellular fuel sensor as the key brain mechanism triggering muscle thermogenesis, with the ultimate goal of identifying targets to increase muscle thermogenesis and caloric expenditure to combat weight gain.

PI_NAMEs: NOVAK, COLLEEN M (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adipose tissue;Affect;Animals;Autonomic nervous system;Behavior;Bioinformatics;Body Weight decreased;Brain;brain pathway;Brain region;Brown Fat;Burn injury;Ca(2+)-Transporting ATPase;Calories;Cells;combat;Data;Endoplasmic Reticulum;energy balance;Energy Intake;Energy Metabolism;Expenditure;experience;Exposure to;Ferrets;fitness;Gastrocnemius Muscle;Goals;Health;Healthcare Systems;Hypothalamic structure;Immunofluorescence Immunologic;Implant;Individual;interest;Knowledge;Measures;Metabolic;Metabolic Pathway;Metabolism;Methods;Microinjections;Modeling;Mus;Muscle;Neural Pathways;neuromechanism;Neurons;Obesity;Odors;Outcome;Peripheral;Persons;pharmacologic;Phosphorylation;Phosphotransferases;Physical activity;Population;Prevention;Process;programs;Protein Dephosphorylation;Rattus;Reader;Regulation;Research;response;Role;satiety center;sensor;SF1;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;stem;Stimulus;Sympathetic Nervous System;Temperature;Testing;Therapeutic;Thermogenesis;Thinness;undergraduate student;Weight Gain;weight maintenance;Western Blotting

PROJECT_TITLE: Neural Mechanisms Underlying Central Induction of Skeletal Muscle Thermogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Persons with type 1 diabetes often have declines in cognitive function over time but the responsible mechanisms are not well understood. There is a growing evidence that the damage begins at diagnosis of diabetes and is especially severe with diabetic ketoacidosis and chronic hyperglycemia. In the proposed project, we will study risk factors for cognitive decline in a comprehensive, multi-center cohort of young children to find out how cognitive decline might be prevented.

PI_NAMEs: REWERS, MARIAN J (contact)

PROJECT_TERMS: Age;Biometry;Brain;Child;Childhood;Childhood diabetes;Chronic;clinical center;Clinical Research;cognitive function;cohort;Cohort Studies;Collaborations;Colorado;comorbidity;Data;Data Collection;Development;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Disease Management;Eligibility Determination;Enrollment;Ethnic Origin;experience;follow-up;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Hyperglycemia;Hypoglycemia;Impaired cognition;Impairment;Insulin-Dependent Diabetes Mellitus;Life;Long-Term Effects;Longitudinal cohort;Manuals;Measures;Medical Records;Modality;Neurocognitive;Newly Diagnosed;operation;Outcome;participant enrollment;Patients;Persons;Play;Policies;Population;prepuberty;prevent;prospective;protective factors;Protocols documentation;psychosocial;Quality of life;Race;Recurrence;Registries;Reporting;Research;Research Infrastructure;research study;Risk Factors;Role;sex;Socioeconomic Status;stem;study population;Testing;Time;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Determinants of Neurocognitive Complications in T1D


ADMINISTERING_IC: EY

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: MEMPHIS

ORG_NAME: TAVO BIOTHERAPEUTICS, INC

ORG_STATE: TN

PHR: Because elevated intraocular pressure (IOP) and IOP fluctuations are the primary risk factors for loss of visual field in glaucoma, the current standard of care for adult-onset glaucoma includes treatment with IOP-lowering medications that are typically delivered topically as eye drops because of their ease of use and the ability for a patient to receive treatment from the comfort of their home. The requirement for multiple daily dosings along with associated eye irritation in addition to orbital and systemic side effects noted in available medications, collectively contribute to the low patient adherence documented by many eye care specialists. To directly address this unmet clinical need to increase patient adherence, within these SBIR Phase 1 studies, we will optimize and evaluate the IOP-lowering properties and safety of a subconjunctival biodegradable electrospun depot containing PRG.

PI_NAMEs: JOHNSON, DIANNA AMMONS (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;Adult;Affect;Agreement;Area;Beds;biocompatible polymer;biodegradable polymer;Biodistribution;biomaterial compatibility;Biomedical Engineering;Blindness;capsule;Caring;Clinical;cost efficient;Data;Deposition;design;Development;Dose;Drops;Drug Delivery Systems;drug distribution;Dryness;Emulsions;Engineering;experience;Eye;Eyedrops;Family;FDA approved;Film;Foreign Bodies;Formulation;Glaucoma;Goals;Grant;Home;innovation;irritation;Liquid substance;Manuals;Marketing;Methods;nanofiber;novel;Outcome Study;Patient Compliance;Patients;Performance;Pharmaceutical Preparations;Phase;phase 1 study;Physiologic Intraocular Pressure;Physiological;Polymers;Positioning Attribute;pregabalin;preservation;Process;Property;Proteins;Reproducibility;Research;response;Risk Factors;Safety;Self Administration;Shapes;side effect;Small Business Innovation Research Grant;Solid;Specialist;spheroids;standard of care;Surface;System;Tablets;Technology;Testing;Therapeutic;therapy development;tool;Topical application;Vision;Visual Fields

PROJECT_TITLE: Development of a novel depot delivery system for a glaucoma therapeutic


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will contribute to fundamental knowledge about the nature of Developmental Language Disorder (DLD), specifically the mechanistic role of short-term verbal memory deficits. Specific outcomes may also hold implications for the differential diagnosis of individuals with DLD regardless of their language(s) and age.

PI_NAMEs: MCGREGOR, KARLA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Age;age related;Attention;attentional control;Categories;Child;Clinical Markers;Cognitive;Communication impairment;Complex;Comprehension;design;Development;Diagnostic;Differential Diagnosis;endophenotype;experience;experimental study;Foundations;Genes;Heart;Human;Individual;innovation;Knowledge;Laboratories;Language;Language Development;Language Development Disorders;Learning;Linguistics;long term memory;Maintenance;Measures;Memory;Memory impairment;Mission;Modeling;Motor;National Institute on Deafness and Other Communication Disorders;Nature;novel;Outcome;Pathway interactions;Pattern;peer;Performance;Phenotype;phonology;phrases;Population;Principal Component Analysis;Probability;rehearsal;Role;Semantics;Sensory;Short-Term Memory;simulation;skills;Specific qualifier value;Structure;sustained attention;System;Testing;theories;United States;verbal;Verbal Learning;visual search;Work

PROJECT_TITLE: Specifying the Short-term Verbal Memory Endophenotype for Developmental Language Disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety

ORG_CITY: OMAHA

ORG_NAME: SILICON CURES LLC

PHR: PROJECT NARRATIVE The objective of this STTR is to enhance ICU-CARE, a mobile app that promotes informal caregiver participation in patient care in the intensive care unit (ICU). Our solution is expected to improve the effectiveness of day-to-day informal caregiving, facilitate symptom assessment and management decisions, and support care communication for over 5 million ICU patients and their informal caregivers.

PI_NAMEs: HETLAND, BREANNA D (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: acceptability and feasibility;Address;application programming interface;attentional control;Beds;caregiver quality of life;Caregivers;Caring;Clinic;Clinical;Clinical Data;clinical practice;Clinical Trials;Collaborations;commercial application;commercialization;common symptom;Communication;Communities;cost;Data;Data Collection;Delirium;design;digital health;direct patient care;diversity and inclusion;Education;Educational process of instructing;Effectiveness;efficacy testing;Electronic Health Record;electronic health record system;Electronics;Elements;Environment;evidence base;experience;follow-up;Goals;graphical user interface;Health Personnel;Health system;Healthcare;Healthcare Systems;Hospitals;implementation barriers;improved;Incidence;industry partner;informal caregiver;informal caregiving;informal support;innovation;Institution;Intensive Care Units;Intervention;Language;Lead;Learning Module;Marketing;Medicine;Methods;mobile application;Morbidity - disease rate;mortality;Nebraska;Neurobehavioral Manifestations;Nonpharmacologic Therapy;Nurses;Outcome;Participant;Patient Admission;Patient Care;patient safety;Patient Self-Report;Patients;Phase;physical symptom;Practice Guidelines;Prevalence;Price;Provider;psychological symptom;Qualitative Methods;Randomized, Controlled Trials;Records;recruit;Sampling;Secure;Security;Severities;Silicon;simulation;Small Business Technology Transfer Research;Spanish;standard of care;symptom management;Symptoms;System;Testing;Time;tool;Translational Research;United States;uptake;usability;user centered design;virtual;Work

PROJECT_TITLE: ICU-CARE: An interactive mobile app to enhance the efficiency of daily informal caregiving in the intensive care unit


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE In this study, we will investigate prospective associations of neighborhood environment features (walkability, playability, transitability) with physical activity and weight status across multiple age groups. Findings will build on previous studies to provide stronger evidence to guide policy and practice around cardiovascular disease prevention and control.

PI_NAMEs: OYEYEMI, ADEWALE  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Address;Adolescence;Adolescent;Adult;Age;age group;age related;Area;Behavior;Birth;Body mass index;Buffers;built environment;Cardiovascular Diseases;cardiovascular disorder prevention;Child;Chronic Disease;Climate;college;Communication;Communities;Crime;Cross-Sectional Studies;Data;Data Analyses;data sharing;demographics;density;Development;disorder control;Education;Educational Status;Environment;Esthetics;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;Floor;follow up assessment;follow-up;Funding;Future;Habits;Health;Health Benefit;Height;Household;indexing;Individual;innovation;International;Investigation;land use;Leisures;life span;Life Style;Measures;Modeling;National Heart, Lung, and Blood Institute;neighborhood association;Neighborhoods;Not Hispanic or Latino;Obesity;older adult;Outcome;Parents;Participant;Patient Recruitments;Patient Self-Report;Physical activity;physical conditioning;physical inactivity;Policies;prospective;Prospective Studies;Race;racial population;Recommendation;Reporting;Research;Research Personnel;Retirement;Risk;Risk Factors;Safety;Sampling;Sampling Studies;secondary analysis;sex;Strenuous Exercise;study characteristics;supportive environment;Testing;Time;United States;United States National Institutes of Health;walkability;Weight;young adult

PROJECT_TITLE: Prospective associations between neighborhood environments and physical activity and weight status across age groups: secondary analyses combining 5 NIH studies

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE (No change from original, funded submission) E-cigarette use produces toxicants, is addictive, and is associated with future use of combustible tobacco among young adults. This project will address significant gaps in our understanding of the influence of e- cigarette advertisement features on young adults’ neurocognitive reactions as well as the perceptions and intentions of using e-cigarettes. It will also provide timely scientific evidence to inform tobacco regulatory decision-making in the areas of e-cigarette marketing influences and behavior.

PI_NAMEs: CHEN-SANKEY, JULIA CEN (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Adopted;Adult;Advertisements;Affect;Age;aged;Area;Arousal;Attention;Authorization documentation;Award;Behavior;Behavioral;behavioral and social science;biological sex;Cannabis;Cigar;Cigarette;cigarette advertising;cigarillos;Clinical Trials;Cognitive;combustible tobacco;comparative;Comparative Study;Compensation;Consent Forms;Control Groups;cost;Curiosities;Data;data de-identification;Decision Making;design;Development;Diameter;Electronic cigarette;electronic cigarette use;Electronic Mail;Eligibility Determination;Emerging Tobacco Products;Emotional;Enrollment;Environment;Exclusion;Expectancy;experience;experimental group;experimental study;Exposure to;Facial Expression;feature selection;Foundations;Friends;Funding;Future;Goals;Harm Reduction;heated tobacco products;Historical Demography;hookah;Image;inclusion criteria;Individual;Individual Differences;Influentials;innovation;Intention;interest;Intervention;Interview;Lead;Maps;marijuana vaping;Market Research;Marketing;Measures;Methods;Modeling;Names;Neurocognitive;Neurosciences;Outcome;Outcome Measure;parent project;Parental Leave;Participant;Perception;PhenX Toolkit;Policies;Policy Making;population health;power analysis;Predisposition;Preparation;prevent;Price;Procedures;Public Health;Pupil;Questionnaires;Randomized;Reaction;Recording of previous events;recruit;Regulation;Research;Research Methodology;response;Sample Size;Sampling;Sensory;Series;Smokeless Tobacco;social;sociodemographics;Statistical Data Interpretation;Stimulus;Surveys;Tail;Technology;Testing;Time;Time Study;timeline;Tobacco;tobacco advertising;tobacco exposure;tobacco products;tobacco regulation;Tobacco use;tobacco user;toxicant;trend;Update;uptake;visual tracking;willingness;Work;young adult

PROJECT_TITLE: Understanding the Influence of E-cigarette Advertisement Features


NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal supports Dr. Alex Herrera’s effort in his leadership of City of Hope Comprehensive Cancer Center’s (COHCCC’s) NCI-funded clinical trials network research as well as his national leadership of NCI-sponsored research. As a City of Hope clinical research leader, Dr. Herrera will facilitate the expansion and integration of the COHCCC clinical trials infrastructure with the goal of enhancing contributions to NCI clinical trials network research and improving the diversity of patients enrolled to NCI-sponsored trials at City of Hope. As a national leader in NCI-sponsored lymphoma research, Dr. Alex Herrera will continue to guide the cancer research agenda for patients with lymphoma, including designing and leading practice-changing clinical trials, and mentoring the next generation of NCI-sponsored clinical research leaders with the goal of reducing the burden of lymphoma and improving survival of patients with lymphoma in the United States.

PI_NAMEs: HERRERA, ALEX F. (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Adolescent;Adult;anti-cancer research;Automobile Driving;Award;Childhood;Cities;City of Hope Comprehensive Cancer Center;Clinical;Clinical Cancer Center;clinical center;Clinical Research;clinical trial enrollment;Clinical Trials;Clinical Trials Network;Collaborations;Comprehensive Cancer Center;design;Disease;equity, diversity, and inclusion;Funding;Goals;Hematology;Hodgkin Disease;improved;Infrastructure;Institution;Investigational Therapies;Lead;Leadership;Lymphoma;member;Mentors;multidisciplinary;National Cancer Institute;National Clinical Trials Network;next generation;Non-Hodgkin's Lymphoma;novel therapeutics;Outcome;Participant;participant enrollment;Patients;Physician Executives;Principal Investigator;programs;Research;Research Activity;Research Infrastructure;Research Personnel;Scientist;Southwest Oncology Group;Specialist;standard of care;translational medicine;trial enrollment;United States;working group;young adult

PROJECT_TITLE: Leading NCI Clinical Trials Network research nationally and at the City of Hope Comprehensive Cancer Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M1)]


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Narrative The UPR is an academic institution that provides undergraduate, graduate, and post-graduate training in core and allied disciplines of OSH. Most of the students that enroll in the IH Program are Natural Science graduates and engineers, all dominating disciplines allied to OSH. The industrial hygiene program provides students with an opportunity for high-quality and rigorous training, to improve the health, safety, and well-being of our nation’s workforce.

PI_NAMEs: DE OLIVEIRA-PIMENTA, ALUISIO C (contact)

PROGRAM_OFFICER_NAME: MAPLES, ELIZABETH

PROJECT_TITLE: University of Puerto Rico Caribbean Center for Professional Industrial Hygiene Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 DVN (03)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project aims to investigate how access to language in the real-world affects the development of language skills of children who are Deaf or Hard of Hearing. It also utilizes EEG to study neural language processing in noisy environments in this population. The study will enhance our understanding of behavioral and neural language development and will inform future interventions for children who are Deaf or Hard of Hearing.

PI_NAMEs: BENITEZ, CARLOS R (contact)

PROJECT_TERMS: Acoustics;Adult;Affect;Age;aged;Area;Auditory;Behavioral;behavioral outcome;Brain;Caregivers;Child;Clinical;Cochlear Implants;Cognitive;cognitive skill;Comprehension;Control Groups;critical period;Cross-Sectional Studies;Cues;deaf;design;Development;effectiveness evaluation;Electroencephalography;Environment;executive function;experience;experimental study;Exposure to;Face;feasibility testing;Friends;Future;Goals;hard of hearing;Hearing;Hearing Aids;Heterogeneity;high risk;Home;improved;indexing;innovation;interest;Intervention;Knowledge;Laboratories;Language;Language Delays;Language Development;language processing;Longitudinal Studies;Masks;Measures;Methodology;Methods;Modeling;neural;neurodevelopment;neuromechanism;neurophysiology;Noise;novel;Nursery Schools;Outcome;Outcome Measure;Pattern;phonology;Population;Preschool Child;recruit;Regression Analysis;Research;Resources;response;Risk;Semantics;Signal Transduction;skills;socioeconomics;sound;Speech;speech in noise;Technology;Testing;tool;Work

PROJECT_TITLE: Assessing Access to Language in the Real-World and Neural Language Processing in Preschoolers who are Deaf or Hard of Hearing

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE This project will identify novel viruses in hematophagous arthropods largely neglected by virus metagenomics. Viruses that replicate in human and vertebrate animal cells will be isolated and characterized. The importance of proactive virus discovery and characterization cannot be understated because it allows effective detection, prevention, control, and treatment practices to be developed before virus spillover events occur.

PI_NAMEs: BLITVICH, BRADLEY J (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Aliquot;Animal Experiments;Applications Grants;Arboviruses;arthropod-borne;Arthropods;Bioinformatics;bioinformatics pipeline;Biological Assay;blind;Blood;Cell Line;Cells;Chironomus thummi;Codon Nucleotides;Collection;combat;Culicidae;Data;design;Destinations;Detection;diagnostic assay;Dinucleoside Phosphates;Ecology;Evolution;experimental study;feeding;Fleas;Frequencies;Future;Goals;Health;High-Throughput Nucleotide Sequencing;Human;human pathogen;In Vitro;in vivo;Incidence;Infection;insight;Invertebrates;Kinetics;Medical;Metagenomics;Methods;Mexico;neglect;nonhuman primate;North America;novel;novel virus;pathogenic virus;Phenotype;Phlebotominae;Phylogenetic Analysis;Plaque Assay;Population;Predisposition;preference;Prevention;Public Health;Quantitative Reverse Transcriptase PCR;Research Design;Risk Assessment;RNA;RNA Viruses;Satellite Viruses;Serology;Seroprevalences;Simuliidae;spillover event;Testing;Ticks;United States;vector;Vertebrates;Viral;viral transmission;virome;Virulence;Virulent;Virus;Virus Replication

PROJECT_TITLE: Defining the virosphere of neglected hematophagous arthropods

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Endocrine Disruptors;Estrogen;Nutrition;Obesity;Women's Health Research

ORG_CITY: SPRINGFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED

ORG_STATE: IL

PHR: PROJECT NARRATIVE Human and animal populations are increasingly exposed to toxic environmental chemicals as a result of living in a heavily industrialized world. Human exposure to dioxins causes both sleep and metabolic disturbances, including increased risk of type II diabetes and metabolic syndrome. This proposal examines the novel hypothesis that dioxins exert their action through aryl hydrocarbon receptor-mediated uncoupling of homeostatic regulation of organismic circadian rhythms.

PI_NAMEs: TISCHKAU, SHELLEY A (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Ablation;adipokines;Adipose tissue;Affect;Agonist;Animals;anthropogenesis;ARNTL gene;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Award;Behavior;Behavioral;Binding;Biological;Blood Glucose;Body Burden;Body Composition;career preparation;Chronic;Chronic Disease;Chronically Ill;Chronotherapy;circadian;circadian behavioral rhythms;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;combat;Cytochrome P450;cytokine;Detection;Development;Diabetes Mellitus;Diabetic mouse;Diet;diet-induced obesity;Dioxins;Eating;Energy Metabolism;environmental chemical;Enzymes;Estrogen Antagonists;Estrogen Metabolism;Estrogen Receptors;Estrogens;exposed human population;Exposure to;Fatty Liver;feeding;Female;food surveillance;Foundations;Functional disorder;Genes;Genetic Transcription;Germ Lines;glucose metabolism;glucose tolerance;graduate student;Grant;Health;Healthcare Systems;Heart Diseases;High Fat Diet;Homeostasis;Hour;Human;In Vitro;Industrialization;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Life Expectancy;Ligands;lipid biosynthesis;Lipolysis;lipophilicity;Liver;Malignant Neoplasms;Measures;Mediating;Medical Students;Mental Depression;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;Modernization;Molecular;molecular clock;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Obesity associated disease;Organ;Ovariectomy;pandemic disease;Periodicity;Phase;Population;Receptor Activation;Receptor Cross-Talk;Regulation;response;Risk;Science;sex;Sex Differences;Signal Transduction;Sleep;Societies;Stains;targeted treatment;Testing;Therapeutic;Time;Time-restricted feeding;Training;Transcription Coactivator;transcription factor;Transcription Process;translational study;Triglycerides;uncoupling protein 1;undergraduate student;Weight Gain;Work;Xenobiotics

PROJECT_TITLE: Aryl hydrocarbon receptor regulation of energy metabolism


NIH_SPENDING_CATS: Data Science;Diabetes;Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE Capitalizing on the pre-existing infrastructure for multi-site analysis and study coordination at the University of Colorado Anschutz Medical Campus, the investigative team will establish the Subtyping Core for Research on the Etiology of Type 2 Diabetes (SCORE-T2D) biostatistics research center. SCORE-T2D will work with the Cohort Sites and NIDDK to employ multi-level, multi-dimensional approaches to characterize heterogeneity in type 2 diabetes in the Consortium. Establishment of SCORE-T2D and completion of the proposed goals will result in a broadly applicable framework for identifying type 2 diabetes subtypes and forge new research opportunities for effective precision interventions to prevent, reroute the clinical course, and optimize long-term prognosis of type 2 diabetes in diverse populations.

PI_NAMEs: KECHRIS-MAYS, KATHERINA  (contact);LANGE, LESLIE A;PERNG, WEI ;YANG, IVANA V

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Age;Algorithms;Behavior;Behavioral;Beta Cell;Biometry;blood glucose regulation;Body mass index;Categories;Cell Physiology;Chronic Disease;Clinical;Clinical Data;clinically relevant;cohort;Collection;Colorado;Communities;comorbidity;Complex;Complications of Diabetes Mellitus;Computer software;computerized data processing;Consensus;Data;Data Analyses;Data Element;data harmonization;data modeling;data sharing;data standards;data submission;Development;Diabetes autoantibodies;diabetes risk;diabetic;Diagnosis;Dimensions;Disease;disorder risk;Ethnic Origin;Etiology;European;experience;FAIR principles;Family;fasting glucose;forging;Functional disorder;Generations;Glycosylated hemoglobin A;Goals;Health;Heterogeneity;high dimensionality;improved;Individual;Infrastructure;innovation;Institution;Insulin;Insulin Resistance;large datasets;Lead;Life course epidemiology;Logistics;Measures;Medical;meetings;Methodology;Methods;Molecular;Monitor;mortality;multilevel analysis;multimodal data;multiple data types;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Non-Insulin-Dependent Diabetes Mellitus;outreach;personalized intervention;Persons;Phenotype;Physiological;Population;Population Heterogeneity;Prediabetes syndrome;prevent;Prevention strategy;Process Assessment;Prognosis;Protocols documentation;Race;recruit;Registries;repository;Research;Resources;response;Risk Factors;Route;Sample Size;Schedule;Shapes;Site;Skin;social;social factors;social health determinants;social structure;sociodemographics;Subgroup;Tissues;treatment response;treatment strategy;Universities;Variant;Visualization;Work

PROJECT_TITLE: Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Effects of Indoor Air Pollution;Immunotherapy;Lung

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE T helper type 2 tissue-resident memory cells (Th2-Trm) are key drivers of allergic asthma due to their persistence in the airways and amnestic responses upon local allergen re-exposure. FoxP3+ regulatory T cells (Tregs) are potent suppressors of allergic inflammation. This proposal explores the possibility that allergen- specific tissue resident (r) Tregs in the lung are particularly effective at suppressing allergic inflammation due to their positioning in a unique niche alongside Th2-Trm through shared chemokine receptor systems.

PI_NAMEs: NELSON, RYAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adoptive Transfer;Advisory Committees;Affect;airborne allergen;airway hyperresponsiveness;Allergens;Allergic;Allergic Disease;Allergic inflammation;Asthma;asthma model;Award;Bioinformatics;Biological Response Modifiers;Boston;Candidate Disease Gene;career development;CCL1 gene;CCL8 gene;CCR8 gene;Cell Maintenance;Cell Separation;Cells;Cellular biology;chemokine;chemokine receptor;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;CRISPR/Cas technology;CXCR6 gene;Data;Development Plans;Disease;disease model;effective therapy;eosinophil;Exposure to;Extrinsic asthma;FOXP3 gene;Funding;Gene Expression Profile;General Hospitals;Genes;Genetic Transcription;genome editing;Goals;Homeostasis;human disease;Immunology;immunoregulation;in vivo;Inflammation;Inflammatory;Inhalation;Interleukin-13;Kinetics;Knowledge;Ligands;Lung;Maintenance;Maps;Massachusetts;Mediating;Memory;Mentors;Mentorship;Metaplasia;Microscopy;Modeling;mouse model;mucosal site;Mucous body substance;Mus;novel;novel therapeutics;Parabiosis;Pediatric Hospitals;Peptides;Phase;Phenotype;Positioning Attribute;programs;Pyroglyphidae;recruit;Regulatory T-Lymphocyte;Reporter;Research;Research Methodology;Research Personnel;Residencies;Resolution;response;Role;single-cell RNA sequencing;skills;Structure of parenchyma of lung;System;Systems Biology;T cell differentiation;T-Lymphocyte;Testing;Th2 Cells;Therapeutic;tissue resident memory T cell;Tissues;Training;transcriptomics;Transgenic Organisms;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Lung resident Treg suppression of Th2 resident memory T cells in allergicasthma

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: PHILADELPHIA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The University of Pennsylvania (UPENN) Occupational & Environmental Medicine (OEM) Train- in-Place Residency, in existence since 1997, remains the largest civilian OEM program in the United States. The program has 165 alumni/graduates and has been supported by NIOSH since program inception. The UPENN OEM Residency has successfully achieved all stated objectives during the prior project periods and intends to continue our efforts towards education and training of OEM physicians.

PI_NAMEs: SAVUL, SAJJAD A (contact)

PROJECT_TITLE: Training the Next Generation of Occupational and Environmental Physicians


ORG_CITY: LOS ANGELES

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative This proposal is relevant to human health because it seeks to elucidate mechanisms of how key processes of protein import and bioenergetics in the mitochondrion are regulated in the yeast model system, and conserved in mammals, that will translate into a better understanding of the molecular basis of a subset of mitochondrial diseases. This project is relevant to NIH’s mission and the mission of the NIGMS because it seeks fundamental knowledge about cellular processes that has the potential for development of strategies for the treatment of mitochondrial disorders.

PI_NAMEs: DABIR, DEEPA VINAY (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Binding;Binding Sites;Bioenergetics;Biogenesis;Biological Models;career;Carrier Proteins;Cell Nucleus;Cell Physiology;Cell Respiration;Cells;Cellular Stress;Chemistry;Client;Complex;Core Protein;Coupled;Cysteine;cysteine rich protein;Cytoplasm;Data;Defect;Deficiency Diseases;Destinations;Development;Disease;disulfide bond;disulfide bond reduction;Disulfides;Electron Transport;Exposure to;Ferredoxin;functional restoration;Funding;Genes;Goals;graduate school;Grant;Health;Homeostasis;Human;in vivo;innovation;insight;Institution;Investigation;Knowledge;Lead;link protein;Mammals;Mediating;Medical;Membrane;Mission;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Myopathies;Mitochondrial Proteins;Modification;Molecular;Mutation;National Institute of General Medical Sciences;novel;Organelles;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Physiologic pulse;Physiological;Physiology;Play;Positioning Attribute;Process;Production;protein function;Protein Import;Protein translocation;Proteins;Proteome;Public Health;Publishing;Reaction;Reactive Oxygen Species;Regulation;Reperfusion Injury;Research;Respiration;respiratory;Respiratory Chain;respiratory protein;Role;Saccharomyces cerevisiae;Saccharomycetales;Science;Series;Side;Structure;Sulfhydryl Compounds;System;Testing;Therapeutic;Thermodynamics;Translating;translocase;treatment strategy;TXN gene;undergraduate student;United States National Institutes of Health;Variant;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Aim32, a multi-faceted redox protein, in mitochondrial biogenesis


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative/Public Health Relevance We will develop novel computational methods that model gene regulatory activity in individual genomes, with important translational implications for genetic association studies of human disease.

PI_NAMEs: GAMAZON, ERIC R;MOHAMMADI, PEJMAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Alleles;analysis pipeline;Architecture;Atlases;Awareness;biobank;Biological;Biological Assay;Chromosome Mapping;Code;Communities;Computational Technique;Computing Methodologies;Data;Data Set;Development;Disease;Disease susceptibility;disorder risk;dosage;Ensure;European ancestry;Gene Dosage;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Determinism;Genetic Models;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomics;Genotype;Genotype-Tissue Expression Project;Haplotypes;Heterogeneity;human disease;improved;Individual;Joints;Lead;Maps;Mediating;Methods;Modeling;Molecular;multi-ethnic;novel;Penetrance;phenome;Phenotype;Population;Population Heterogeneity;Protein Isoforms;Proteins;public health relevance;Regulation;Research Personnel;Resolution;Resources;Sampling;Scientist;segregation;Signal Transduction;Statistical Methods;Testing;Tissues;tool;trait;Transcript;transcriptome;Variant;virtual

PROJECT_TITLE: Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populations

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative: Dr. Akhil Chawla has demonstrated long-term commitment to the support of NCI sponsored studies within at Northwestern and nationally through his service and leadership within the Alliance for Clinical Trials in Oncology (Alliance) and the National Cancer Institute (NCI). Dr. Chawla has focused goals to design and implement novel and practice changing clinical trials through Alliance, increase his impact within the NCI, lead integration to enhance infrastructural expansion to community cancer sites to reach underserved populations at Northwestern, and provide formalized mentorship to early career investigators. Together with his experience, leadership, and dedication, Dr. Chawla will serve as a lifelong supporter of the NCI clinical trials program at an institutional and national level.

PI_NAMEs: CHAWLA, AKHIL  (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Advocate;cancer site;career;Chicago;Clinical;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Country;Dedications;design;Development;Disease;Enrollment;experience;Faculty;Geography;Goals;Grant;Health;Health system;Illinois;Infrastructure;Institution;Lead;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;Mentors;Mentorship;National Cancer Institute;North America;novel;Oncology;Play;Population Heterogeneity;Positioning Attribute;Principal Investigator;programs;protocol development;Protocols documentation;Quality Control;Race;Research;Research Personnel;Role;Science;Services;Site;success;Surgical Oncologist;Underserved Population;Universities

PROJECT_TITLE: National and Institutional Leadership and Support of NCI-Sponsored Clinical Trial Research as a Surgical Oncologist


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: 8. Project Narrative  Stress-related neuropsychiatric disorders including anxiety disorders and depression represent a significant public health problem, however the underlying neural causes of these disorders are poorly understood. The research outlined in this proposal will provide a detailed understanding of circuit and cellular mechanisms by which stress-related neuropsychiatric disorder models (anxiety and depression) are enhanced after social isolation during the critical period of adolescence. These studies will identify novel targets for the discovery of more effective treatments and interventions for these debilitating disorders.

PI_NAMEs: LUKKES, JODI L (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Adverse effects;Adverse event;Amygdaloid structure;Animals;antagonist;Anxiety;Anxiety Disorders;Attenuated;Aversive Stimulus;Behavior;behavioral response;biological adaptation to stress;Brain;Cells;Childhood;Coping Behavior;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRF receptor type 2;critical period;current pandemic;Data;Depressive disorder;Development;disability;Disease;disease model;dorsal raphe nucleus;effective intervention;effective therapy;Electrophysiology (science);enhancing factor;Event;Exhibits;experience;FOS gene;Functional disorder;Glutamates;in vivo;Lead;Learned Helplessness;Life;Long-Term Effects;Major Depressive Disorder;male;Measures;Mediating;Mental Depression;Mental disorders;mental function;Mental Health;Molecular;Mood Disorders;mRNA Expression;nano-string;National Institute of Mental Health;Negative Valence;nerve supply;neural;neural circuit;neuromechanism;neuronal circuitry;neuronal excitability;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;optogenetics;Output;peer;postnatal;Prefrontal Cortex;Prevalence;Property;Prosencephalon;Public Health;Publishing;Rattus;receptor expression;Regulation;Reporting;Research;Research Domain Criteria;resilience;response;Risk;Risk Factors;Role;Serotonergic System;Serotonin;Signal Transduction;Slice;social;Social Interaction;Social isolation;Socialization;Stress;stressor;Structure of terminal stria nuclei of preoptic region;Synapses;System;United States

PROJECT_TITLE: Long-term effects of adolescent social isolation on the interactions between CRF and serotonergic systems

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: NEW ROCHELLE

ORG_NAME: QUA, INC.

ORG_STATE: NY

PHR: PPAL® PHASE II PROJECT NARRATIVE Toileting injuries have detrimental effects on older adults and individuals with mobility disability; new, easy-to- use technologies that enable more efficient and safer toilet transfers are desperately needed. This Phase II project continues the development and testing of a novel bedside commode (the “PPAL®”) that enables care recipients to transfer themselves onto a commode to toilet, rather than wait for caregiver lift assistance. The PPAL® uniquely engages the transfer skill of care recipients to manage their own transfer onto a commode. In so doing, it advances the clinical science of fall prevention and (by reducing the manual labor required for toileting assistance), safe patient handling and mobility.

PI_NAMEs: GRAHAM, MARGARET ELLEN (contact)

PROJECT_TERMS: Adult;Adverse event;Age;aged;Aging;Algorithms;Area;arm;Articular Range of Motion;base;Beds;care recipients;Caregiver Burden;Caregivers;Caring;Clinical;clinical decision support;Clinical Sciences;Community Participation;cost;Data;design;Development;Devices;Diameter;Engineering;Equipment;Evaluation;fall injury;Fall prevention;fall risk;falls;fear of falling;Feedback;Formal caregiver;Goals;Guidelines;Health;Height;Home;Hospitals;improved;Incidence;Individual;Individuals with physical disabilities;informal caregiver;Injury;innovation;Institution;Interview;iterative design;Legal patent;Lifting;Location;Manuals;manufacturability;Mechanics;Methods;Mobility disability;Motor;Movement;novel;nursing skill;older adult;Older Population;operation;Outcome;Patient Transfer;Patients;Persons;Phase;phase 1 study;phase 2 study;Populations at Risk;Positioning Attribute;Posture;preservation;Production;prototype;Published Comment;Quality of life;Rehabilitation therapy;residence;Resort;Risk;Risk Reduction;safe patient;Self Efficacy;skills;Small Business Innovation Research Grant;Surface;System;Technology;Testing;tool;United States National Institutes of Health;usability;Weight;Wheelchair user;Wheelchairs;Work;Workers' Compensation

PROJECT_TITLE: Development and Evaluation of the PPAL Bedside Commode for Safe Independent Toileting Transfers


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE We will conduct a phase II clinical trial of a novel targeted therapy combination in specific genomic subsets of two types of thyroid cancer: recurrent and/or metastatic differentiated thyroid carcinoma that does not respond to radioiodine and anaplastic thyroid cancer. To expeditiously determine the most effective use of this combination, we will assess the correlation of clinical findings with molecular analyses of biopsy tissues collected before and during treatment to identify the most promising ways this combination works against thyroid cancer. In differentiated thyroid cancer, we will also examine the potential of this combination to restore sensitivity to radioidine.

PI_NAMEs: HO, ALAN L. (contact)

PROGRAM_OFFICER_NAME: WEIR, NARGUES

PROJECT_TITLE: Phase II trial of avutometinib plus defactinib in RAF dimer-driven thyroid cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-S (01)]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The Sunshine Education and Research Center focuses on interdisciplinary training of occupational safety and health professionals, training in evidence-based practice and research, continuing education and outreach. The home base for the ERC is in the University of South Florida College of Public Health and offers programs collaboratively with the USF Colleges Nursing and Arts and Sciences, with Embry-Riddle Aeronautical University (ERAU) (Daytona Beach FL) and with the University of Central Florida (UCF) (Orlando FL). The academic programs are Occupational Health Nursing, Occupational Health Psychology, and Health Safety and Environment (HSE) at USF plus Occupational Safety Management from ERAU and Targeted Research Training at UCF; while we have phased out the industrial hygiene and occupational medicine training programs, we propose to add the DrPH in occupational health, safety and wellness and an MPH/Certificate program in social marketing.

PI_NAMEs: MARSHALL, JENNIFER  (contact)

PROJECT_TITLE: Sunshine Education and Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 EHG (05)]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Currently there are not enough people trained in occupational safety and health to protect the US workforce, particularly those trained in industrial hygiene practice and research. The University of Oklahoma Health Sciences Center offers an ABET-accredited Master of Science degree in Industrial Hygiene and Environmental Health Sciences and a PhD degree in Occupational and Environmental Health that prepare students to anticipate, recognize, evaluate, and control occupational hazards. The training project grant will provide tuition and stipend support to attract students of diverse technical and cultural backgrounds into the occupational safety and health professional workforce, and prepare a new generation of industrial hygiene faculty and researchers.

PI_NAMEs: FLOYD, EVAN LEE (contact)

PROJECT_TITLE: Great Plains Training for Industrial Hygiene Practice and Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Disability Research;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Individuals with hearing loss often have trouble pinpointing the location of an audible sound source, particularly in noisy environments, but the reason for this is unknown. This project is to determine whether this localization deficit is reflected in an early stage of how the brain processes sound.

PI_NAMEs: DAY, MITCHELL LEE (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Acoustics;Adult;Anesthesia procedures;Animal Model;Area;Auditory;Auditory Brainstem Responses;auditory pathway;awake;Behavior;behavior measurement;Behavioral;Binaural;Brain;Brain Stem;Cell Count;Cell Nucleus;Chronic;clinically relevant;Cochlea;Code;cohort;Comprehension;Confocal Microscopy;Cues;Data;Data Collection;Environment;Exhibits;experimental study;Exposure to;Food;food restriction;Frequencies;Funding;Goals;Hair Cells;Head;Hearing;hearing impairment;hearing range;Human;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Impairment;Implant;Individual;Inferior;Inferior Colliculus;Inner Hair Cells;Lead;Location;Loudness;Measures;Midbrain structure;Nerve Fibers;neural;Neurons;Neurophysiology - biologic function;Noise;Noise-Induced Hearing Loss;normal hearing;novel;Operant Conditioning;Oryctolagus cuniculus;Outer Hair Cells;Pattern;Performance;permanent hearing loss;Physiological;Population;Process;Reporting;response;Rewards;Sensorineural Hearing Loss;sound;Sound Localization;Source;Speech;Stains;Stimulus;Synapses;Techniques;Testing;Time;Training;transmission process

PROJECT_TITLE: Effect of Sensorineural Hearing Loss on the Neural Coding of Spatial Hearing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Anorexia nervosa is a severe psychiatric illness with high mortality but uncertain underlying pathophysiology, and no biological treatments have been approved. In this application, we will establish a novel neurobiological target in individuals with anorexia nervosa and propose new treatment interventions that involve diet and brain glucose metabolism to normalize altered eating and their relationship with body weight and shape.

PI_NAMEs: FRANK, GUIDO KW (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acids;Anorexia Nervosa;Anxiety;anxiety reduction;Behavior;behavior measurement;Behavioral;Biological;Biological Response Modifier Therapy;Blood;body dissatisfaction;Body fat;Body Size;Body Weight;Brain;burden of illness;Carbohydrates;Cells;Cerebrum;Characteristics;Clinical;Clinical assessments;Cognitive;cohort;comparison control;Control Groups;Death Rate;Dependence;Development;Diet;Dietary Intervention;Disease;Distress;Dose;Eating;Eating Disorders;Emaciation;Emotional;emotional symptom;Endocrinology;energy efficiency;Energy Metabolism;Energy-Generating Resources;Etiology;Excess Mortality;experience;Fatty acid glycerol esters;Fatty Acids;Feeling;fluorodeoxyglucose;food restriction;Fright;frontal lobe;Functional disorder;functional outcomes;Genetic study;Glucose;glucose metabolism;Goals;Homeostasis;Impairment;improved;Individual;Inflammatory;inflammatory marker;Intervention;ketogenic diet;Ketone Bodies;Ketones;Ketosis;Lead;Link;Maintenance;Measurement;Measures;meetings;Mental disorders;Metabolic;Metabolic Diseases;Metabolic Marker;Metabolic Pathway;metabolic rate;Metabolism;Middle frontal gyrus structure;Mitochondria;Modeling;Moods;mortality;Neurobehavioral Manifestations;Neurobiology;Neurologic;Neurotransmitters;novel;Overweight;Oxidative Stress;Participant;Phase;Positron-Emission Tomography;Process;Psychopathology;Recovery;recruit;reduce symptoms;reduced food intake;relapse risk;Reporting;Research;response;restraint;retention rate;reward circuitry;Risk Factors;Safety;Sampling;severe psychiatric disorder;Shapes;Signal Transduction;social;Starvation;Stress;symptomatic improvement;System;Therapeutic;Therapeutic Use Study;trait;Translating;Treatment Cost;uptake;Weight;Weight Gain;weight restoration

PROJECT_TITLE: Ketogenic Diet in Weight Recovered Anorexia Nervosa to Target Metabolism and Normalize Persistent Eating Disorder Psychopathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (03)]


ADMINISTERING_IC: HS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Each year, roughly 600,000 patients served in U.S. trauma centers develop posttraumatic stress disorder or depression after traumatic injury, but few receive mental health follow-up care. The Trauma Resilience and Recovery Program is a sustainable, stepped-care model that has addressed the mental health needs of over 8,000 patients in four Level I-II trauma centers and is being adopted by 8 additional trauma centers in the Carolinas. This study will examine the effectiveness and implementation of TRRP with a diverse sample of 350 patients served at The George Washington University hospital.

PI_NAMEs: RUGGIERO, KENNETH J (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Testing a Scalable Model of Care to Improve Patients’ Access to Mental Health Services after Traumatic Injury

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Prevention;Rare Diseases

ORG_CITY: PROVO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative  Forward genetic screens have been one of the most prolific sources for identifying genes underlying human disease, especially birth defects. We are using CRISPR technology to rapidly screen gene mutations that affect heart development. We are then characterizing their effects and studying their mechanisms of action.

PI_NAMEs: HILL, JONATHON T (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: accurate diagnosis;Acute;Adoption;Affect;Alleles;Amaze;Animals;Area;Automobile Driving;Calcium;Calcium Signaling;Candidate Disease Gene;candidate identification;Cardiac;cardiogenesis;causal variant;Cell Count;Cells;Chemicals;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Abnormality;Congenital Heart Defects;CRISPR library;CRISPR screen;CRISPR/Cas technology;Dedications;Defect;Development;Developmental Biology;Developmental Process;Diagnosis;disability;Education;Embryo;Embryonic Development;Embryonic Heart;Ethylnitrosourea;Etiology;Exhibits;Exocytosis;expectation;experience;Experimental Designs;experimental study;Fluorescence;Future;gene discovery;Gene Mutation;Gene Targeting;Generations;Genes;Genetic Screening;Genetic screening method;Genetic Transcription;Genome;Grant;Heart;Heart Atrium;High-Throughput Nucleotide Sequencing;Human;human disease;improved;Injections;Institution;interest;Ligands;malformation;Measures;Mentorship;Methods;model organism;Modernization;Morphogenesis;Morphology;Mutagenesis;mutant;Mutate;Mutation;novel;Pathway interactions;Phenotype;programs;Proteins;Rapid screening;Research;Resources;Role;Science;screening;Screening Result;Signal Transduction;skills;Source;Speed;Students;System;Tail;Testing;Time;Tissues;transgene expression;undergraduate student;Underrepresented Populations;United States;Ventricular;vesicle transport;Width;Work;Zebrafish

PROJECT_TITLE: Developing a CRISPR-based forward-genetic screening method in embryonic zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Program Director/Principal Investigator (Last, First, Middle): Reed, Rustin J. Project Narrative Americans spend a major part of their adult lives in the workplace and increasingly, the adverse effects of workplace conditions, exposures, and stressors on workers’ health are being recognized. This academic Training Program addresses this public health issue through our goal of training qualified masters-level industrial hygienists - front line professionals engaged in the primary prevention of occupational injury and illness - with a special focus on the recruiting of minority student trainees. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: REED, RUSTIN JAMES (contact)

PROJECT_TITLE: Occupational Safety and Health Training Project Grants


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_NAME: SAINT JOSEPH'S UNIVERSITY

PHR: Project Narrative: Cell polarity and migration are critical life-long process required for developmental processes and homeostatic maintenance, as well as during the body’s response to external insults and disease states including wound-healing and tumor metastasis. The prior funded cycle identified a key mechanistic signaling pathway responsible for driving changes in cell architecture. The goals of the next funding cycle build upon these discoveries and new hypotheses that will determine how this signaling pathway coordinates the cellular machinery required for directed migration.

PI_NAMEs: MYERS, KENNETH ALBERT (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Architecture;Award;Behavior;Biological Process;Blood Vessels;cell motility;Cell Polarity;Cell Shape;Cells;Centrosome;Complex;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Developmental Process;directional cell;Disease;Endothelial Cells;experimental study;Family;Fluorescence Microscopy;Focal Adhesions;Funding;Future;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Health;Heart Diseases;Heart Neoplasms;immunocytochemistry;Investigation;Knowledge;Link;live cell imaging;Maintenance;Measurement;Measures;Mediating;Membrane;Microfilaments;Microscopy;Microtubule Polymerization;Microtubule-Associated Proteins;Microtubules;migration;MMP14 gene;Molecular Motors;Monomeric GTP-Binding Proteins;Movement;Myosin ATPase;Myosin Type II;Neoplasm Metastasis;optogenetics;Outcome;Peripheral;polarized cell;Process;Protein Family;Proteins;Publishing;recruit;Regulation;Research Design;Research Personnel;Resolution;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Stress Fibers;System;Testing;Traction;trafficking;tumor;undergraduate student;Work;wound healing

PROJECT_TITLE: Control of cell polarity and migration by non-centrosomal microtubules


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Type I diabetes (T1D) is linked to the gut microbiota, yet the underlying mechanism remains unclear. The proposed research investigates how T cell response to commensal microbes contributes to T1D and the potential use of gut immune responses as cellular biomarkers for disease prediction. Data generated from this study will provide fundamental knowledge on the underlying pathology in T1D and may uncover new biomarkers for early disease.

PI_NAMEs: NAJI, ALI ;SU, LAURA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Bacterial Antigens;Biological Markers;Blood;Budgets;CD4 Positive T Lymphocytes;Cell Communication;Cell Separation;Cellular Stress;Child;Clinical;clinical diagnosis;Collaborations;commensal bacteria;commensal microbes;cost;cross reactivity;Data;diabetes pathogenesis;Disease;Disease Progression;Donor person;Duodenum;early detection biomarkers;Early Diagnosis;Early Intervention;Environment;Environmental Risk Factor;Exhibits;exposed human population;Genetic;genetic signature;Goals;gut microbiota;Homeostasis;Human;Immune;Immune response;Individual;insight;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intestines;islet autoimmunity;Islets of Langerhans;Knowledge;Lamina Propria;Life;Link;Lymphocyte;Maps;Microbe;microbial;microbial composition;microorganism antigen;Molecular Mimicry;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Onset of illness;Organ Transplantation;Pancreas;Pathology;Patients;Pattern;Pennsylvania;Peptide/MHC Complex;peripheral blood;Peripheral Blood Mononuclear Cell;Physiological;predictive signature;Predictive Value;programs;Property;Recommendation;Reporting;Research;Resources;response;Risk;risk stratification;Sequence Analysis;Signal Transduction;Site;Specificity;T cell differentiation;T cell response;T-cell receptor repertoire;T-Lymphocyte;Testing;Text;Tissues;translational goal;Universities;Viral Antigens

PROJECT_TITLE: From Gut to Blood: Dissecting the mechanisms of CD4+ T cell pathology in islet autoimmunity across tissue environments.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M2)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Lung;Lymphatic Research;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative Our laboratory studies how estrogen modules immunity to promote progression of a rare and devastating lung disease found almost exclusively in women called lymphangioleiomyomatosis (LAM). In human patients and in animal models, estrogen promotes progression of LAM; however, estrogen does not only directly stimulate LAM cells - instead, it also enhances neutrophil production and activation and inhibits T cells, both of which lead to LAM progression. Understanding these mechanisms will apply not only to LAM but to many other cancers.

PI_NAMEs: HAMMES, STEPHEN R. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Air;Androgens;Animal Model;Aromatase Inhibitors;Attenuated;Autoimmunity;Biological Markers;Biology;Bone Marrow;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cell surface;Cells;Coculture Techniques;Communicable Diseases;Contraceptive methods;Cyst;cytokine;Data;Disease;Enzymes;ESR1 gene;Estradiol;Estrogens;Female;Genes;Genetic;Genomics;Growth;Hormones;Human;human RNA sequencing;immune function;Immune response;Immune system;Immunity;immunoregulation;In Vitro;in vivo;Inflammatory;interest;Invaded;Knock-in;Knock-out;Knockout Mice;Knowledge;Laboratories;Laboratory Study;Lesion;Leukocyte Elastase;Life;Lung;lung colonization;Lung Diseases;Lung Lymphangioleiomyomatosis;Lung Transplantation;Lymphangioleiomyomatosis;Malignant Neoplasms;Mediating;melanocyte;Metastatic Neoplasm to the Lung;migration;Modeling;mouse model;Mus;Mutation;Myometrial;myometrium;Natural Immunity;Nature;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;neutrophil;Nodule;non-genomic;novel;novel marker;Null Lymphocytes;Oral;Ovariectomy;Patients;Physiology;Plasma;Postmenopause;Pregnancy;Production;Puberty;Publishing;pulmonary function;Rare Diseases;Reporting;response;Role;Serum;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Steroids;Suppressor-Effector T-Lymphocytes;Surface;T-Cell Activation;T-Lymphocyte;therapeutic target;Tissue Sample;Tissues;transcriptome sequencing;Transplant Recipients;TSC1 gene;TSC2 gene;Tuberous Sclerosis;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-Derived;Uterus;Woman;Work

PROJECT_TITLE: Examining Sexual Dimorphisms:  The Role of Estradiol Signaling in Modulating Immunity

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

PHR: PROJECT NARRATIVE Validated patient-reported outcome measures (PROMs) can quantify knee osteoarthritis (OA) symptoms but clinicians lack guidelines to interpret PROMs in individual patient care. We will define PROM interpretation guidelines for pain and physical function in knee OA patients in primary and specialty care, including patients recovering from TKR. PROM interpretation guidelines will be tailored to demographic and comorbidity profiles to serve diverse patients.

PI_NAMEs: FRANKLIN, PATRICIA D (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Adopted;Adoption;Adult;Aftercare;Age;Arthritis;Cardiopulmonary;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical;clinical care;Clinical Research;clinically relevant;Cognition;Cognitive;cohort;comorbidity;Data;Degenerative polyarthritis;Demographic Factors;design;Electronic Health Record;Emotional;Ethnic Origin;Evaluation;Feasibility Studies;Funding;Future;future implementation;Guidelines;Health;Health system;improved;Individual;Individual Adjustment;individual patient;Knee Osteoarthritis;knee replacement arthroplasty;Knowledge;Medical;medical specialties;men;Modeling;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Obesity;Operative Surgical Procedures;Orthopedics;osteoarthritis pain;Outcome;Outcome Measure;Pain;Pain management;Pain Measurement;Patient Care;Patient Outcomes Assessments;Patients;Persons;Physical Function;Physical therapy;Primary Care;Professional Organizations;prospective;provider adoption;Psychometrics;Race;radiological imaging;Regulation;Rehabilitation therapy;Reporting;Research;Research Personnel;Roentgen Rays;Sampling;Severities;sex;Site;social factors;sociodemographic factors;Standardization;Subgroup;Surgeon;Symptoms;Technology;Testing;Time;tool;United States Centers for Medicare and Medicaid Services;Western Ontario and McMaster Universities Arthritis Index;Woman

PROJECT_TITLE: Clinical Interpretation of PROMs in Care of Knee Osteoarthritis and TJR

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Decades of exciting progress in gene-based treatments for inherited retinal diseases (IRDs) have led to dozens of promising clinical trials with gene augmentation therapy. For the subset of severe binocular congenital blinding conditions called LCA, the greatest benefit is likely to be in children before the window of brain plasticity closes. This research plan is designed to perform a clinical trial using innovative outcome measures in adolescents with LCA5, and develop novel outcomes to evaluate efficacy in young children taking part in future trials.

PI_NAMEs: ALEMAN, TOMAS S (contact)

PROGRAM_OFFICER_NAME: XU, LEI

PROJECT_TITLE: Gene Therapy for LCA5-Assocated Inherited Retinal Degeneration: Extension to Pediatric Cohorts


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Rare Diseases

ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Henry, Michael F. Project Narrative This proposed research seeks to better understand the causes of mitochondrial disorders; a group of diverse diseases that includes cancer, infertility, diabetes, heart disease, blindness, deafness and neurodegenerative diseases. The yeast model organism will be used to study a feature of mitochondrial genome expression conserved in humans. This information is necessary for discovering the underlying causes of mitochondrial disorders and may help identify potential therapies that could prevent, or even reverse, mitochondrial diseases.

PI_NAMEs: HENRY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Alleles;Antibiotics;Bacterial Infections;Binding;Biochemical;Biogenesis;Biological Assay;Blindness;cancer biomarkers;Cells;Characteristics;Client;Clinical;clinically significant;Complex;crosslink;Cytoplasm;Data;deafness;Dedications;Defect;Degenerative Disorder;Diabetes Mellitus;Disease;Docking;Energy Metabolism;experimental study;Gene Modified;Goals;Heart Diseases;Human;Hypertrophic Cardiomyopathy;in vivo;Individual;infancy;Infertility;innovation;insight;Leigh Disease;Macromolecular Complexes;Malignant Neoplasms;Maps;Membrane;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Mitochondrial Matrix;model organism;Modeling;Molecular;Molecular Chaperones;Molecular Structure;mutant;Mutation;N-terminal;Nature;Neurodegenerative Disorders;Nuclear;Organism;Orthologous Gene;overexpression;Oxidative Phosphorylation Deficiency;Pathway interactions;Patients;Physiological;prevent;Process;Production;Prognosis;Property;protein protein interaction;Protein Subunits;Proteins;Reactive Oxygen Species;Reporting;Research;Respiratory Chain;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;Role;Saccharomyces cerevisiae;scaffold;Sensorineural Hearing Loss;Side;side effect;Site;Small RNA;Structure;targeted cancer therapy;Tissues;tumor progression;Yeast Model System;yeast protein;Yeasts

PROJECT_TITLE: Chaperoning Preassembly Modules for Mitochondrial Ribosome Assembly


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposed research aims to investigate the prevalence of cardiometabolic medication substitution and its potential long-term health outcomes among older adults in the transition from acute hospitals to skilled nursing facilities (SNFs). Leveraging a novel nationwide SNF electronic health record linked to Medicare data will provide a comprehensive investigation of this prevalent practice. The evidence generated from this work can offer better guidance for clinicians and healthcare systems on safe medication management within post-acute care settings.

PI_NAMEs: PARK, CHAN MI  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;acute care;Acute myocardial infarction;Address;Affect;Agonist;Angiotensin Receptor;Angiotensins;Anticoagulants;Applications Grants;Award;beneficiary;cardiometabolism;Cardiovascular system;career development;Caring;Cause of Death;Characteristics;Chronic Disease;Clinical;Clinical Trials;clinically significant;cost;Data;Databases;Dementia;Diabetes Mellitus;Dipeptidyl Peptidases;Disease Outcome;Electronic Health Record;Ensure;Epidemiology;Event;experience;Formularies;frailty;Frequencies;Geriatrics;GLP-I receptor;glucagon-like peptide 1;Glucose;Health;Health Services Research;Healthcare Systems;Heart failure;High Prevalence;Home;hospital care;Hospitals;inhibitor;innovation;Inpatients;interest;Investigation;K-Series Research Career Programs;Knowledge;Link;Location;Long-Term Care;Long-Term Effects;Longitudinal Studies;Medicare;Medicare claim;medication administration;Medication Management;Mentorship;Neprilysin;neuropsychiatry;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Polypharmacy;Predisposition;Prevalence;Principal Investigator;Process;programs;Provider;Records;Regimen;Renin;Research;Research Personnel;Resolution;Site;Skilled Nursing Facilities;Sodium;Stroke;Sulfonylurea Compounds;symporter;Testing;Training;Work

PROJECT_TITLE: Epidemiology and Long-Term Effect of Cardiometabolic Medication Substitution during Post-acute Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: In our previous research, we discovered neurons in the brain that produce the unpleasant quality of pain. Here, we have assembled a multidisciplinary team to launch a drug discovery program. Our goal is to develop molecules that can act on act these neurons and produce a novel type of painkiller that can treat pain emotional suffering across all pain types.

PI_NAMEs: AUBE, JEFFREY ;SCHERRER, GREGORY  (contact);SCHNITZER, MARK J

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;addiction;Affective;Amygdaloid structure;Analgesics;antinociception;Behavior;beta-arrestin;Binding;Biochemistry;Bioinformatics;Biological Assay;Biology;Brain;brain pathway;Catalogs;Cerebral cortex;Characteristics;clinically relevant;cocaine self-administration;commercialization;conditional knockout;Cryoelectron Microscopy;Dangerousness;designer receptors exclusively activated by designer drugs;Dimensions;Docking;drug development;drug discovery;Drug Industry;drug seeking behavior;efficacy study;efficacy testing;Electrophysiology (science);Emotional;Etiology;experience;Funding;G-Protein-Coupled Receptors;Goals;Histologic;Human;Human Genome;human tissue;imaging modality;in silico;in vivo;Intellectual Property;Knockout Mice;Libraries;Ligands;Machine Learning;Mediating;Medicine;Methods;Motivation;mouse genetics;mouse model;mu opioid receptors;multidisciplinary;Mus;Nature;neural;neural circuit;Neurons;Neurotensin Receptors;non-opioid analgesic;novel;Opioid;Opioid Analgesics;Outcome Measure;Pain;pain behavior;pain model;pain perception;Pain quality;pain reduction;pain relief;painful neuropathy;patient advocacy group;Patient Representative;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physicians;Positioning Attribute;positive allosteric modulator;Positron-Emission Tomography;Postoperative Period;programs;Property;Proteins;Reporting;Research;Resolution;Rodent;Science;side effect;Signal Transduction;single-cell RNA sequencing;Slice;small molecule;Standardization;Structure;Techniques;Testing;tool;transcriptomics;Translations;Ventilatory Depression;Work

PROJECT_TITLE: Developing small molecules to engage an analgesic GPCR in pain unpleasantness neural circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (18)]


PI_NAMEs: SCHERRER, GREGORY  (contact)

PROJECT_TERMS: Achievement;Address;Analgesics;Basic Science;clinical translation;Collaborations;collaborative environment;Communication;Communities;data management;data sharing;Diverse Workforce;drug development;Ensure;experience;field study;Fostering;Funding;G-Protein-Coupled Receptors;General Population;Goals;graduate student;Grant;Guidelines;Helping to End Addiction Long-term;Human Resources;Infrastructure;Institution;Interdisciplinary Communication;Interdisciplinary Study;International;Lead;Leadership;Liquid substance;meetings;Mentorship;Monitor;multidisciplinary;Nature;neural circuit;Office of Administrative Management;organizational structure;Pain;Policies;Postdoctoral Fellow;Productivity;programs;Progress Reports;recruit;Reporting;Research;Resources;small molecule;success;symposium;Training;undergraduate student;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Chronic Pain;Data Science;Neurosciences;Pain Research

PI_NAMEs: SCHNITZER, MARK J (contact)

PROJECT_TERMS: Address;Adopted;Analgesics;Area;Back Pain;Code;Collaborations;Common Data Element;Consultations;Data;Data Aggregation;Data Analyses;Data Collection;Data Discovery;data harmonization;data hub;data management;data repository;data reuse;Data Science;Data Set;data sharing;data submission;Deposition;drug development;drug discovery;Drug Kinetics;Ensure;experience;FAIR principles;G-Protein-Coupled Receptors;Generations;Helping to End Addiction Long-term;Human Resources;implementation tool;Individual;Infrastructure;Institution;Knowledge;large datasets;Leadership;Letters;Life Cycle Stages;Metadata;multidisciplinary;Nature;neural;neural circuit;Neurosciences;operation;Outcome Measure;Pain;petabyte;Pharmaceutical Chemistry;Pharmacodynamics;Pharmacology;Policies;preservation;programs;Protocols documentation;Publications;Qualifying;quality assurance;Reporting;repository;Research;small molecule;Specialist;Staging;Standardization;success;Technology;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PROJECT_TERMS: Acute;Addictive Behavior;Affective;Age;Agonist;Amygdaloid structure;Analgesics;analog;Animal Model;antinociception;Anxiety;arrestin 2;Arrestin Beta 1;Attention;Behavior;Behavioral;beta-arrestin;Bioinformatics;Biological Assay;Biology;Body part;Brain;BRAIN initiative;calcification;Catalogs;Cells;Censuses;Chronic;chronic neuropathic pain;chronic pain;Clinical;clinically relevant;comparative;designer receptors exclusively activated by designer drugs;Development;Dimensions;Dose;Dose Limiting;Drug Prescriptions;Drug usage;Electrophysiology (science);Evaluation;Excision;experimental study;G-Protein-Coupled Receptors;Genes;Genetic Diseases;Genetic Transcription;GNAQ gene;Human;human tissue;Hypotension;Image;Knockout Mice;Knowledge;Label;Ligands;LoxP-flanked allele;male;Mechanics;Methods;Modality;Motivation;motor impairment;mouse genetics;mouse model;Mus;natural hypothermia;neural circuit;neuronal excitability;Neurons;Neuropathy;Neurotensin;Neurotensin Receptors;new therapeutic target;Nociception;novel;Operative Surgical Procedures;osteoarthritis pain;Outcome Measure;Pain;pain behavior;pain model;pain reduction;pain score;Peptide Fragments;Peripheral;positive allosteric modulator;Postoperative Period;Process;Property;Reflex action;Reporting;Research;Resources;Rewards;Rodent;Science;sex;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;small molecule;Source;spontaneous pain;Stimulus;Testing;therapeutic target;Tissues;tool;transcriptomics;translational medicine;translational potential;Translational Research;Translations;United States National Institutes of Health;Validation;validation studies;Visceral pain;Withdrawal;Work

PROJECT_TITLE: Validation of Therapeutic Target and Underlying Biology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

PROJECT_TERMS: Acute;addiction;Affective;Analgesics;analytical method;Anesthetics;Animal Model;antinociception;Area;Behavior;behavioral outcome;Brain;Cells;Cerebral cortex;cingulate cortex;Classification;clinically relevant;Conscious;Consensus;cranium;Cre-LoxP;Data;Development;drug discovery;drug efficacy;efficacy study;experience;Experimental Designs;fluorescence microscope;G-Protein-Coupled Receptors;Genetic Techniques;Human;Image;imaging modality;improved;in vivo;in vivo imaging;Individual;innovation;invention;Machine Learning;machine learning method;machine learning pipeline;Manuals;meetings;Methods;Microscope;Modeling;Motivation;Motor;mouse genetics;mouse model;Mus;Names;Nature;Neocortex;neural;neural circuit;neuroimaging;Neurons;Neurosciences;Nociception;novel;Optics;Outcome Measure;Pain;pain behavior;Pain quality;Pain Research;painful neuropathy;Pattern;Postoperative Period;pre-clinical;public-private partnership;Recommendation;Reporting;Reproducibility;Research;response;Rodent;Safety;Sensory;Shapes;small molecule;Somatosensory Cortex;Source;Standardization;System;Technology;Testing;translational clinical trial;Unconscious State;United States Food and Drug Administration;Validation;working group

PROJECT_TITLE: Development and Validation of Animal Models and/or Outcome Measures


PROJECT_TERMS: Action Potentials;Affinity;Agonist;Allosteric Site;Analgesics;analog;Arrestins;assay development;beta-arrestin;Binding;Biochemistry;Biological Assay;Bioluminescence;Brain;Cells;Characteristics;Closure by clamp;Complex;Data;Development;Disease;DNA;Docking;Drug Kinetics;Electrophysiology (science);Energy Transfer;Enterobacteria phage P1 Cre recombinase;Environment;experience;Frequencies;G-Protein-Coupled Receptors;Genes;Growth;GTP-Binding Proteins;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Individual;Ion Channel;Label;Libraries;Ligand Binding;Ligands;Membrane Potentials;Molecular Weight;Mus;Nature;neural circuit;neuronal excitability;Neurons;novel;Pain;patch clamp;permissiveness;Pharmaceutical Chemistry;physical property;Physiological;positive allosteric modulator;Property;Protein Subunits;rational design;receptor expression;red fluorescent protein;Reporter;Reporting;Research;scaffold;Science;screening;Signal Pathway;Signal Transduction;Site;Slice;small molecule;Structure;success;System;Testing;Visual;voltage

PROJECT_TITLE: Assay Development, Screening and Early Optimization