ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Today, for lack of appropriate technology there is scant information on how genetically defined neuron-types coordinate their collective dynamics across multiple brain areas. To break this barrier, we created the ‘Octopus’, a robotic imaging system comprising 4 or more mechanically articulated arms, each a two- photon microscope, for simultaneous imaging of neural activity in multiple deep or superficial brain areas of individual rodent or primate subjects. In this project, we will enhance and prepare the Octopus for widespread dissemination by: (1) upgrading the optics, so that each arm incorporates optogenetics and can perform dual-color two-photon imaging at video frame-rates across an 800-µm-wide field-of-view; (2) refining the mechanical design of the articulated arm to simplify its initial assembly for new users and improve its versatility; (3) working with 7 beta-tester labs to iteratively improve the performance and usability of the Octopus and to validate its capabilities as a groundbreaking new tool for imaging multi-area neural dynamics.

PI_NAMEs: SCHNITZER, MARK J (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Achievement;Address;Adoption;Anatomy;Animal Behavior;Animals;Area;arm;arm movement;Articular Range of Motion;Articulation;Auditory area;awake;Basal Ganglia;Behavior;Brain;BRAIN initiative;Brain region;Callithrix;cell type;Cells;Cerebellum;Cognitive;Color;Communities;Data;design;design,build,test;Development;dexterity;Distal;Endowment;Feedback;flexibility;Fluorescence;Freedom;Generations;Genetic;Head;Image;Imaging Device;imaging modality;imaging study;imaging system;Imaging Techniques;improved;Individual;Institution;Intuition;invention;kinematics;Lateral Geniculate Body;lens;Lighting;Location;manufacture;Mechanics;meter;Methods;microendoscope;Microscope;microscopic imaging;Microscopy;millimeter;miniaturize;Monitor;Motion;Motor;motor behavior;Motor Cortex;Mus;neural;neuroimaging;Neurons;Neurosciences;new technology;Octopus;open source;Operative Surgical Procedures;optical imaging;Optics;optogenetics;Performance;Population;Positioning Attribute;Preparation;Primates;Pulvinar structure;Readiness;Research;restraint;Robot;Robotics;Rodent;Role;Rotation;Route;Scanning;Sensory;Shipping;Site;superior colliculus Corpora quadrigemina;System;Techniques;Technology;Thalamic structure;Tissues;tool;two-photon;usability;Visible Radiation;Visual;Visual Cortex;Work

PROJECT_TITLE: A robotic multi-armed two-photon microscope for imaging neural interactions across multiple brain areas


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Hematology;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Blood cancers account for approximately 10% of all malignancies and allogeneic bone marrow transplantation (BMT) is a major curative therapy, but is limited by transplant related complications, predominantly graft-versus- host disease (GVHD) that is often fatal. The proposal will study and define rapidly testable therapeutic approaches to prevent GVHD based on preventing the initiation of disease (i.e. alloantigen presentation) rather than broad suppression of T cells in the late effector phase of disease, as is current practice. In this manner we will define new strategies to prevent the side effects of transplantation, whilst permitting the development of robust immunity to pathogens.

PI_NAMEs: HILL, GEOFFREY ROGER (contact);KOYAMA, MOTOKO

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute Graft Versus Host Disease;Adrenal Cortex Hormones;Affect;Alloantigen;Allogeneic Bone Marrow Transplantation;Antigen Presentation;Antigen-Presenting Cells;Antigens;Aplastic Anemia;ATAC-seq;Bone marrow failure;Bone Marrow Transplantation;Calcineurin inhibitor;CD4 Positive T Lymphocytes;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Cues;curative treatments;Cyclophosphamide;cytokine;Cytokine Receptors;Cytokine Signaling;Cytomegalovirus;Data;Death Rate;design;Development;Disease;Disease Outcome;Disparate;effective therapy;effector T cell;Epithelial Cells;Epithelium;Event;Flow Cytometry;gastrointestinal epithelium;Gastrointestinal tract structure;Generations;genetic manipulation;graft vs host disease;graft vs leukemia effect;Hematopoietic;Hematopoietic Neoplasms;ileum;Immune Cell Suppression;immune reconstitution;Immune response;Immunity;immunodeficiency;improved;Infection;Inflammation;Inflammatory;innovation;insight;Interruption;Intervention;intestinal epithelium;Intestines;leukemia;Life;Lymphocyte;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;MHC Class I Genes;MHC Class II Genes;Modeling;Molecular;mortality;mouse model;Mus;Natural Killer Cells;Non-Malignant;novel;novel therapeutic intervention;novel therapeutics;Opportunistic Infections;Outcome;pathogen;Pathogenicity;Pathway interactions;Patients;Peptide Initiation Factors;permissiveness;Phase;Population;post-transplant;pre-clinical;preclinical study;prevent;Prevention;Process;Proteins;Refractory;Resolution;response;RNA;Role;Sampling;sequencing platform;Severe Combined Immunodeficiency;side effect;Small Intestines;stem cells;Steroids;System;T cell differentiation;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Transplant Recipients;Transplantation;Work;XCR1 gene

PROJECT_TITLE: Preventing GVHD by inhibition of alloantigen presentation in the gut

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Martell project narrative (2-3 sentences) Technologies that enable the identification of which proteins reside in specific locations inside cells are critical for elucidating biological processes and disease states, including neurodegeneration, pathogenic infection, and cancer. One promising strategy to achieve this goal is proximity labeling (PL), but in order to enhance the sensitivity and specificity of proximal protein detection, improved PL catalysts are needed. We propose that hybrid biological-abiotic PL catalysts developed in our laboratory will enhance both sensitivity and specificity in spatially- resolved proteomic mapping, and we are employing these catalysts in neurons to benchmark their performance against existing methods and establish their broad utility as research tools.

PI_NAMEs: MARTELL, JEFFREY DANIEL (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Amino Acids;Benchmarking;Biological;Biological Process;Biotin;cancer cell;catalyst;Cells;Chemicals;Collaborations;Communities;Data Set;Detection;detection sensitivity;Development;Diffuse;Diffusion;Directed Molecular Evolution;Disease;DNA;Doctor of Philosophy;enzyme substrate;Enzymes;Exhibits;Genetic;Goals;Heme;Hybrids;improved;In Vitro;Infection;interest;Kinetics;Label;Laboratories;Length;Location;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Methodology;Methods;Molecular;nano;nanorod;Nanostructures;Nanotechnology;Nerve Degeneration;Neurons;novel;novel strategies;Pathogenicity;Performance;Peroxidases;phenoxy radical;protein function;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;Radial;Reaction;Research;Resolution;scaffold;Sensitivity and Specificity;Shapes;Site;Specificity;Structure;Surface;Synapses;Synaptic Cleft;synthetic construct;System;Technology;Tertiary Protein Structure;three dimensional structure;tool;Tyrosine

PROJECT_TITLE: Hybrid Biological-Abiotic Proximity Labeling Catalysts for Enhancing Spatially-Resolved Proteomics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: PATHOLOGY

PHR: Public Health Relevance/Narrative: . Alzheimer’s disease (AD) is one of the most prevalent and impactful diseases in the United States and throughout the developed world; currently there are limited therapeutic options available to treat AD. This project seeks to benefit public health by determining the mechanism by which the metabolite β-hydroxybutyrate modifies the pathogenesis of AD. The proposed work is expected to result in new information that can inform the development of new therapeutic strategies or treatments for AD.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA;REY, FEDERICO E;ULLAND, TYLER KENT (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acute;Address;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Antibodies;Apoptosis;Attenuated;Autopsy;Bacteria;Behavior;beta-Hydroxybutyrate;Biological Markers;Bone Marrow;Brain;brain metabolism;Brain region;brain tissue;Butyrates;C-terminal;CASP1 gene;Caspase;Central Nervous System;Cessation of life;Cognition;Cognitive;cognitive function;cohort;Communities;Data;Dementia;Deposition;Development;Diet;Diet Modification;Dietary Supplementation;Disease;disease model;Disease Progression;drinking water;Encephalitis;Feces;follow-up;Germ-Free;glial activation;Gliosis;Gnotobiotic;gut colonization;gut microbes;gut microbiome;gut microbiota;Human;human old age (65+);improved;in vivo;Individual;Inflammasome;Innate Immune Response;Innate Immune System;ketogenesis;ketogenic diet;Ketone Bodies;Ketones;Knowledge;Link;Liquid substance;Macrophage;Mediating;Memory impairment;Metabolic;Metabolism;Metagenomics;microbiome composition;Microglia;mouse model;Mus;Neurofibrillary Tangles;novel;novel strategies;novel therapeutic intervention;older adult;Pathogenesis;Pathology;Persons;Plasma;Play;prevent;Proteins;Public Health;public health relevance;receptor;recruit;Reporting;Research;Rodent;Role;Senile Plaques;success;Supplementation;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic development;Therapeutic Uses;therapy development;Tissues;United States;Wisconsin;Work

PROJECT_TITLE: ß-hydroxybutyrate inhibition of pathology in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunization;Immunotherapy;Nanotechnology;Natural Products;Skin Cancer;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Melanoma is the deadliest form of skin cancer and new treatments are needed to improve patient survival. Here we propose the development of therapeutic melanoma vaccines that train the immune system to recognize and destroy melanoma cells using my lab's unique mRNA delivery platform termed Tannic Acid Lipid Nanoparticles.

PI_NAMEs: FENTON, OWEN S (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Animals;Antigens;Antitumor Response;Benchmarking;BRAF gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;chemical property;Clinic;Clinical;cost;CTLA4 gene;Cytoplasm;Dendritic Cells;Dose;FDA approved;Formulation;gp100 Antigen;Growth;head-to-head comparison;Human;Immune checkpoint inhibitor;Immune system;immunogenicity;improved;In Vitro;in vivo;interest;lipid nanoparticle;lymph nodes;manufacturing cost;MEKs;Melanoma;Melanoma Cell;Melanoma Vaccine;melanoma-associated antigen;Messenger RNA;Metastatic Melanoma;mouse model;mRNA delivery;Mus;novel;Patients;Peptides;Pfizer-BioNTech COVID-19 vaccine;Population;Process;Production;programmed cell death protein 1;Property;RNA vaccine;Skin Cancer;Tannic Acid;targeted treatment;Therapeutic;therapeutic development;therapeutic vaccine;Toxic effect;Training;Transfection;treatment response;tumor;Tumor Antigens;Tumor Escape;Tumor Suppression;Tumor-Infiltrating Lymphocytes;uptake;vaccine formulation;virtual;Work

PROJECT_TITLE: Optimization of Tannic Acid Lipid Nanoparticles for a Therapeutic mRNA Vaccine Against Melanoma

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: BARNARD COLLEGE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research aims to discover how biophysical adaptation mechanisms that permit the retina to adapt its computational function contribute to neural encoding. These studies would help us to understand how the circuits of the brain, more generally, flexibly navigate their computational objectives. In elucidating part of the neural code that contributes to adaptable neural circuit function, this project will broadly benefit neuroscience and public health.

PI_NAMEs: GUTIERREZ, GABRIELLE JACQUELINE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Area;Biological;Biophysical Process;Biophysics;Brain;Brain Diseases;career development;cell type;Code;Compensation;Complex;Computer Models;Cone;design;Electrophysiology (science);Environment;experimental study;flexibility;ganglion cell;Goals;improved;Individual;Interdisciplinary Study;Knowledge;Light Adaptations;luminance;Medical;Mentors;Modeling;neural;neural circuit;Neurons;Neurophysiology - biologic function;Neurosciences;Pathway interactions;Phase;Photoreceptors;predictive modeling;Presynaptic Terminals;Process;Property;Public Health;receptive field;Research;response;Retina;Retinal Ganglion Cells;Rod;Role;Sensory;Signal Transduction;skills;spatiotemporal;Stimulus;targeted treatment;Technology;Testing;Training;Universities;Vision;Visual;Visual Cortex;Visual System;Washington;Work

PROJECT_TITLE: Effects of Local Adaptation on Parallel Pathway Circuit Computations in the Retina


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: EL PASO

ORG_DEPT: BIOLOGY

ORG_NAME: EL PASO COMMUNITY COLLEGE

ORG_STATE: TX

PHR: The Rise to the Challenge Bridge to Health and Bioinformatics Program will prepare El Paso Community College students to transfer to the University of Texas at El Paso with the skills to successfully graduate with a Baccalaureate degree in biomedical sciences. The program will prepare them to conduct research and with the skills to enter the Bioinformatics and Health Informatics workforce. Given the location on the US-Mexico Border region and the large percentage of Hispanic students enrolled at both institutions, the program will generate a cadre of diverse biomedical professionals with a vested interest, and the skills to contribute to the improvement of the quality of life on the border and the health of the nation.

PI_NAMEs: ALVAREZ, MARIA E (contact);DUARTE-GARDEA, MARIA O.

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Awareness;Bachelor's Degree;Bioinformatics;Biology;Biomedical Research;career;career awareness;career preparation;Chemistry;Collaborations;community college;Community Networks;computer science;data resource;Data Science;Degree Completion;disadvantaged student;Educational Curriculum;Equity;experience;Faculty;Funding;genome resource;Goals;Graduate Degree;Health;Health Sciences;Health Technology;Internships;Intervention;Knowledge;Mathematics;minority student;Mission;Pathway interactions;programs;Public Health Education;Public Health Informatics;Research;Research Training;Resources;Rest;Science;skills;Students;supplemental instruction;Talents;Texas;tool;transfer student;undergraduate research experience;Universities;university student

PROJECT_TITLE: Rise to the Challenge Bridge to Health Informatics and Bioinformatics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Microbiome;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Increased rates of obesity and diabetes parallels the increased pesticide usage in the United States, especially the use of glyphosate, to date, no study has comprehensively examined the impact of glyphosate exposure on the development of obesity and diabetes. The current work will determine if glyphosate impairs metabolic homeostasis, and if this is due to changes in the gut microbiota. These studies will help understand the impact of environmental exposures on host metabolism and could lead to more targeted therapeutic approaches to treat metabolic disease.

PI_NAMEs: DUCA, FRANK ANTHONY (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Adult;Affect;Agriculture;antagonist;Antibiotics;Bacteria;bacterial metabolism;bile acid metabolism;Bile Acids;blood glucose regulation;Chemicals;Chlorinated Hydrocarbons;Chronic;Complex;Coupled;Data;Development;Diabetes Mellitus;Disease;Dose;Economic Burden;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Impact;Enzymes;Exhibits;Exposure to;Female;Genetic;Germ-Free;Glucose;glyphosate;Goals;gut microbiome;gut microbiota;Health;Herbicides;High Fat Diet;Homeostasis;Human;impaired glucose tolerance;Impairment;Incidence;Industry;Insecticides;insight;Intestines;Knockout Mice;late life;Life;Link;male;Malignant Neoplasms;Mammalian Cell;Mammals;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;microbial;microbiota;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity development;obesity risk;obesity treatment;Pathway interactions;Pesticides;Physiological;Plants;Play;Prevalence;Rattus;receptor;Receptor Activation;Receptor Signaling;Regulation;Research;Rodent;Role;Roundup;Safety;shikimate;Signal Pathway;Signal Transduction;Small Intestines;social;targeted treatment;Testing;Time;United States;Weaning;Weight Gain;Work

PROJECT_TITLE: The Ability of Glyphosate to Impair Metabolic Homeostasis Via the Gut Microbiome and Metabolites

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: GALVESTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Dissecting the mechanisms of Quaking-regulated RNA processing Project Narrative: Gene expression controls nearly every biological process and is essential for life. The Quaking family of RNA binding proteins regulate diverse forms of RNA processing during development and their dysregulation can cause disease. This proposal will use the QKI5 isoform as a model RBP to dissect the fundamental regulatory mechanisms it uses to regulate RNA splicing, localization, and stability/decay to better understand how it influences global gene expression.

PI_NAMEs: FAGG, WILLIAM SAMUEL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Binding;Biochemical;Biological Process;Cell Extracts;Cells;Communities;Complex;Coupled;Data;Decision Making;Development;Disease;Drug Design;Family;Gene Expression;Genomics;Goals;graduate student;Heart Diseases;Homeostasis;Human;Individual;Knowledge;Laboratories;Life;Malignant Neoplasms;Mission;Modeling;Molecular;Molecular Genetics;mRNA Precursor;Mus;Postdoctoral Fellow;programs;Protein Isoforms;protein protein interaction;Regulation;Research;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Schizophrenia;Spliceosomes;Therapeutic;Tissue-Specific Gene Expression;Training;Transcript;transcriptome

PROJECT_TITLE: Dissecting the Mechanisms of Quaking-Regulated RNA Processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cancer immunotherapies have provided significant benefit for many cancer patients, but the treatment of tumors with low mutational burden that lack immune cell infiltration remains a major roadblock. To further expand immunotherapies to many more cancer types, the proposed project aims to validate a novel technology that improves tumor immunogenicity by enhancing the visibility of tumors to immune cells through RNA editing approaches.

PI_NAMEs: HUBBELL, JEFFREY A. (contact);ROSENTHAL, JOSHUA J.C.

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Abscopal effect;anti-PD-1;Antigen Targeting;Benchmarking;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer type;Catalytic Domain;Cells;cellular transduction;Clinical;Combined Modality Therapy;comparative efficacy;Complex;Data;Dependovirus;Development;Disease remission;Distant;DNA;DNA sequencing;DRADA2b protein;dsRNA adenosine deaminase;Engineering;Enzymes;Epitope spreading;Epitopes;Evaluation;Event;Flow Cytometry;Goals;Growth;Human;Hyperactivity;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune system;immunogenicity;Immunologics;Immunotherapy;improved;Infiltration;Injection of therapeutic agent;Injections;innovation;innovative technologies;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Measures;Melanoma;mouse model;Mus;Mutation;neoantigens;neoplastic cell;new technology;novel;Organoids;Outcome;patient subsets;Patients;Point Mutation;pre-clinical;preclinical efficacy;preclinical study;Primary Neoplasm;Process;Production;Proteins;Proteomics;Radiation therapy;Research;Research Project Grants;response;RNA Editing;Safety;Site;Solid Neoplasm;standard of care;T cell infiltration;T cell response;T-Lymphocyte;Technology;technology validation;Testing;therapeutic RNA;transcriptome;transcriptome sequencing;transcriptomic profiling;Translating;translation to humans;translational approach;translational potential;treatment strategy;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Suppression;Tumor-infiltrating immune cells;Vaccinated;Validation;Viral;Work

PROJECT_TITLE: Inducing Tumor Neoantigens Through RNA Editing for Cancer Immunotherapy


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The proposed research is relevant to NIH’s public health mission because it investigates how genetic factors and psychosocial stressors (i.e., spousal psychiatric disorders) come together to influence alcohol use disorder onset, remission, and relapse. Ultimately, it is hoped that the findings from this work will have implications for how spousal psychiatric disorders might be integrated as part of family-based preventive interventions to reduce the substantial social and personal costs associated with alcohol problems.

PI_NAMEs: SALVATORE, JESSICA E (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Affect;African ancestry;Alcohol abuse;Alcohol consumption;alcohol risk;alcohol use disorder;Alcohols;anti social;Antisocial Personality Disorder;Attention deficit hyperactivity disorder;Behavior;behavior influence;contagion;cost;Couples;Data;Data Analyses;Dependence;Diagnosis;Disease;Disease remission;Drug abuse;Drug Use Disorder;Environmental Risk Factor;Epidemiology;European ancestry;Family;Female;Funding;gene environment interaction;Generalized Anxiety Disorder;Genetic;Genetic Predisposition to Disease;Genetic study;genetics of alcoholism;genome wide association study;Genotype;Goals;Husband;Illicit Drugs;Individual;innovation;Knowledge;Major Depressive Disorder;marijuana use disorder;Marriage;member;Mental disorders;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nature;Nicotine Dependence;Onset of illness;Outcome;Phenotype;Post-Traumatic Stress Disorders;Predisposition;preventive intervention;psychosocial stressors;Psychotropic Drugs;Public Health;Recording of previous events;Relapse;Research;Sampling;sex;social;social genomics;social stress;Spouses;Stress;substance use;symptomatology;System;Testing;theories;transmission process;United States National Institutes of Health;Work

PROJECT_TITLE: A genetically informative approach to understanding the impact of spousal psychiatric disorders on alcohol use disorder onset, remission, and relapse

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Cost Effectiveness Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Influenza;Pneumonia and Influenza;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it will develop analytical decision models to optimize the use of non-pharmaceutical interventions with the objectives of minimizing the mortality and morbidity associated with COVID-19 while also minimizing the disutility and disruptions caused by these interventions. Such decision models could allow policymakers to contain the spread of SARS-CoV-2 while also normalizing the society to the greatest extend possible. Therefore, the proposed research is relevant to the NIH’s mission to improve population health.

PI_NAMEs: YAESOUBI, REZA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;adverse outcome;Affect;analytical tool;Benchmarking;Cessation of life;Clinical;Communicable Diseases;Communication;Consumption;cost;Cost Effectiveness Analysis;COVID-19;COVID-19 burden;COVID-19 pandemic;COVID-19 test;Data;Decision Modeling;design;economic disparity;Economics;Education;Effectiveness;epidemic response;epidemiologic data;Epidemiology;evidence base;experience;experimental study;Exposure to;Fatigue;Future;Geography;Health;Health Care Visit;health disparity;Health Insurance;Hospitalization;Immune response;Immunization;improved;income insurance;Influenza;Influenza A Virus, H1N1 Subtype;innovation;Interruption;Intervention;intervention cost;Lifting;marginalization;Masks;Measures;member;Mental Health;Methods;Mission;Modeling;Morbidity - disease rate;mortality;novel;Outcome;pandemic disease;pandemic influenza;pandemic response;pathogen exposure;Persons;Play;Policies;Policy Maker;Politics;Population;population health;predictive modeling;previous pandemic;programs;Public Health;Quality-Adjusted Life Years;Quarantine;Recommendation;Relaxation;Research;Role;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 positive;SARS-CoV-2 transmission;Schedule;school closure;Schools;seasonal influenza;social;Social Distance;Societies;sociodemographics;Source;Specific qualifier value;Structure;Substance Use Disorder;Target Populations;Time;tool;United States;United States National Institutes of Health;vaccine-induced immunity;Vaccines;Variant;Virus;Weight

PROJECT_TITLE: A decision tool to inform the optimal use of non-pharmaceutical interventions during the COVID-19 pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(91)S]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Mental Illness;Prevention;Telehealth;Tourette Syndrome

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Building on our pilot work, this randomized clinical trial (RCT) will test the efficacy of a novel, remotely delivered mindfulness-based group intervention for tics (MBIT) for reducing tic severity and improving common comorbid mental health conditions and quality of life. It will also examine the mechanism by which MBIT reduces tic severity and explore its long-term therapeutic benefit. As ~60% of adults with Tourette Syndrome and persistent tic disorders (collectively TS) do not respond to first-line treatments, MBIT may serve as the first new evidence-based non-pharmacological treatment for TS in over 10 years.

PI_NAMEs: MCGUIRE, JOSEPH  (contact);REESE, HANNAH ELIZABETH

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: 18 year old;Adult;Adverse effects;Aftercare;Anxiety;Attention deficit hyperactivity disorder;Awareness;Behavior Therapy;Childhood;Clinical Trials;comorbidity;comparative efficacy;Development;Disease remission;Distress;efficacious treatment;efficacy evaluation;efficacy testing;electronic data capture system;emotion regulation;Emotional;Esthesia;evidence base;Evidence based treatment;Exhibits;experience;FDA approved;follow up assessment;follow-up;Functional impairment;Gilles de la Tourette syndrome;group intervention;Health;Impairment;improved;Individual;Intervention;Learning Skill;Link;Masks;Meditation;Mental Depression;Mental Health;mindfulness;mindfulness intervention;Motor Tics;Nonpharmacologic Therapy;novel;Participant;Pathway interactions;Patients;Personal Satisfaction;Pharmaceutical Preparations;Pharmacotherapy;premonitory sensory phenomena;Provider;psychoeducation;Quality of life;Randomized;randomized, clinical trials;Recommendation;Relaxation Therapy;remote delivery;remote group;response;Secure;Severities;Stress;stress reduction;Supportive care;Symptoms;telehealth;Therapeutic;therapy outcome;Tic disorder;tic related;Training;treatment group;treatment trial;trial comparing;Vocal Tics;Work;Yoga

PROJECT_TITLE: Remote Delivery of a Mindfulness-Based Intervention for Tics


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The 1p/19q codeletion is a molecular hallmark of oligodendrogliomas. This proposal will capitalize on metabolic vulnerabilities induced by the 1p/19q codeletion for oligodendroglioma therapy and for non-invasive metabolic imaging of response to therapy. By pioneering the development of a genomically guided precision therapy and companion imaging biomarkers of treatment response, our studies have the potential to significantly improve outcomes and quality of life for oligodendroglioma patients.

PI_NAMEs: VISWANATH, PAVITHRA  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 19q;1p36;Adult;Anabolism;Astrocytes;Astrocytoma;Bioenergetics;Biological Assay;Biological Markers;Brain Neoplasms;brain tissue;Cancer Patient;Cells;Cessation of life;Chemotherapy and/or radiation;Chromosomes;Citric Acid Cycle;Classification;Clinic;Clinical;clinical translation;clinically relevant;Cognitive;Cognitive deficits;Colon Carcinoma;Combined Modality Therapy;Companions;Compensation;Deuterium;Development;Drug Kinetics;enolase;Enzymes;Genes;genetic signature;Genomic medicine;Genomics;Glioma;Glucose;glucose metabolism;Glycolysis;Goals;Growth;Human;Image;imaging biomarker;imaging modality;improved outcome;in vivo;inhibitor;innovation;Isocitrate Dehydrogenase;Label;Life;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;metabolic imaging;Metabolism;metabolomics;Modeling;Molecular;Molecular Genetics;Mus;mutant;Mutation;Neuroblastoma;non-invasive imaging;novel;novel therapeutics;oligodendroglioma;Oncology;Outcome;Oxidation-Reduction;Patients;Phosphoenolpyruvate;phosphoglycerate;precision medicine;Precision therapeutics;Primary Brain Neoplasms;Primates;Production;Proliferating;Protein Isoforms;pyruvate dehydrogenase;Quality of life;rational design;Recurrence;Reporting;response;Safety;Specificity;standard care;Testing;Therapeutic;Translating;Translations;treatment response;tumor

PROJECT_TITLE: Targeting metabolic vulnerabilities induced by the 1p19q codeletion in oligodendrogliomas


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: PROJECT NARRATIVE Epilepsy is a neurological condition with an increasing burden in many low- and middle income countries (LMICs). The chronicity of the disease, seizure complications, poorly controlled seizures, stigma, coexisting chronic diseases and social isolation negatively impact health related quality of life. This project will build upon promising pilot work and capacity building conducted in Uganda to further test a self-management program that has the potential to reduce epilepsy burden in Uganda and other LMICs.

PI_NAMEs: KADDUMUKASA, MARK  (contact);SAJATOVIC, MARTHA X

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Adherence;Adopted;Adverse effects;Affect;Africa South of the Sahara;age related;anti-epileptic agents;Anticonvulsants;Awareness;behavior change;Benchmarking;Biological Response Modifier Therapy;Brain;brain health;Cellular Phone;Characteristics;Chronic Disease;Clinical;Clinical Trials Design;Collaborations;comorbidity;comparative efficacy;Competence;Data;Education;Educational Curriculum;effectiveness/implementation design;efficacy evaluation;Ensure;Environment;Epilepsy;Evaluation;Event;evidence base;Face;Family;Fogarty International Center;follow-up;Frequencies;functional status;Future;Goals;Health;health related quality of life;Health Services Accessibility;help-seeking behavior;Hybrids;implementation design;implementation science;improved;Individual;Infrastructure;innovation;Intervention;life span;low and middle-income countries;medication compliance;Mental Depression;Mental Health;Methodology;Methods;mHealth;Monitor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurology;next generation;Outcome;Outcome Assessment;Participant;Patient Self-Report;Patients;Persons;Pilot Projects;primary outcome;Productivity;Proliferating;Promoting Action on Research Implementation in Health Services framework;prospective;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Research Personnel;Residencies;Resource-limited setting;Resources;response;Risk Factors;Rural;Sampling;scale up;secondary outcome;Seizures;Self Efficacy;Self Management;self-management program;sex;Site;Social isolation;social stigma;Social support;standard of care;Substance abuse problem;Symptoms;Testing;Text;Text Messaging;Training;treatment as usual;treatment response;Uganda;Well in self;Work;work-study;Writing

PROJECT_TITLE: Self-management Intervention for Reducing Epilepsy Burden among Ugandans with Epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(55)R]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Coronary artery calcium (CAC) testing provides a direct measure of an individual’s atherosclerotic burden that is robustly associated with cardiovascular disease risk and is recommended by national and international guidelines for the allocation of primary prevention medications. Currently, there is a lack of data on sex and race/ethnicity-specific CAC percentiles across the lifespan that is representative of the whole US population and there is no centralized website/resource to guide clinical interpretation of CAC scores. We will combine 10 datasets to create a harmonized CAC Synthetic Cohort Lifetime Pooling Project (CACSC-LPP) enabling calculation of sex and race/ethnicity CAC percentiles across the lifespan that will be translated into a website/app to serve as the definitive resource for interpretation of CAC scores.

PI_NAMEs: BLAHA, MICHAEL J;WHELTON, SEAMUS PAUL (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Adult;Agatston Score;Age;American;Asian population;Aspirin;biological age;Calcium;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cholesterol;Clinical;cohort;Collaborations;Companions;Consumption;Coronary Arteriosclerosis;coronary artery calcium;Data;data harmonization;Data Pooling;Data Set;data standards;Decision Making;emerging adult;Ensure;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Foundations;Future;Gender;Guidelines;human very old age (85+);improved;Individual;Infrastructure;innovation;Institution;International;Investments;life span;lifetime risk;Lipids;Literature;Location;Measures;middle age;mobile application;Modernization;multidisciplinary;National Heart, Lung, and Blood Institute;Older Population;Participant;Patient risk;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;point of care;Population;Positioning Attribute;premature atherosclerosis;Prevention Guidelines;Prevention therapy;Preventive;Primary Prevention;prototype;Race;racial diversity;racial minority;Recommendation;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Rural;sex;Source;South Asian;Techniques;Testing;Time;tool;Translating;treatment strategy;United States National Institutes of Health;web site

PROJECT_TITLE: Coronary artery calcium synthetic cohort and lifetime percentile project (CACSC-LPP)

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative We aim to gain a deep understanding of the mechanism by which certain types of immune cells support cancer development. Our study will directly guide the development of novel therapeutic strategies for cancer treatment.

PI_NAMEs: ZHANG, CHENGCHENG  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adaptor Signaling Protein;anti-cancer;anti-cancer therapeutic;Binding;Binding Proteins;Biological Assay;Biology;Blocking Antibodies;Breast Cancer Patient;cancer immunotherapeutics;cancer therapy;Cell Fate Control;Cell Reprogramming;checkpoint receptors;Data;Development;extracellular;Extracellular Protein;Family;Family member;Galectin 4;Goals;Human;Human Activities;humanized mouse;Immune;immune checkpoint;Immune response;immunoregulation;Immunosuppression;In Vitro;inhibiting antibody;inhibitor;innovation;Inositol;ITIM;leukemia treatment;Leukocytes;Ligand Binding;Ligands;Malignant Neoplasms;Maps;Mediating;member;Membrane Glycoproteins;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;myeloid leukemia cell;Myeloid-derived suppressor cells;novel;novel therapeutic intervention;Pathway interactions;Phase I Clinical Trials;Phosphoric Monoester Hydrolases;Population;Primates;Protein Tyrosine Phosphatase;Proteins;PTPN6 gene;receptor;receptor binding;recruit;Regulation;Reporter;Research;Role;Signal Pathway;Signal Transduction;Solid;STAT3 gene;Supporting Cell;Testing;TRAF2 gene;Transgenic Mice;Transgenic Organisms;tumor;tumor microenvironment;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Reprogramming myeloid cells to inhibit cancer development

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Emergency Care;Heart Disease;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Epinephrine is the primary medication used when treating patients suffering from a cardiac arrest despite developing evidence that epinephrine may make neurologic outcomes worse. The objective of this study is to test a new endovascular therapy that can improve perfusion to the heart and brain in patients who have suffered a cardiac arrest. The results from this study will provide a greater understanding of the effects of epinephrine on the brain in cardiac arrest as well as provide the data required to determine if clinical trials of this endovascular therapy are warranted in cardiac arrest victims.

PI_NAMEs: JOHNSON, MICHAEL AUSTIN (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Algorithms;Animals;Aorta;Automation;Biological Markers;Blood flow;Blood Pressure;blood pressure control;Blood Vessels;Brain;Cardiac;Cardiopulmonary Resuscitation;Caring;Case Series;Catheters;Cell Death;Cerebral Ischemia;cerebral ischemic injury;Cerebrovascular system;Cerebrum;Circulation;Clinical;Clinical Research;Clinical Trials;Coronary;coronary perfusion;Critical Care;Data;Descending aorta;Devices;Discipline of obstetrics;Distal;emergency settings;Epinephrine;Equipment;experimental study;Extracorporeal Membrane Oxygenation;femoral artery;Foundations;Future;Goals;health care settings;Heart;Heart Arrest;heart function;Heart Injuries;hemodynamics;Hemorrhage;Histologic;Histology;Hospitals;Hour;improved;improved outcome;innovation;interest;Intervention;ischemic injury;Laboratories;Lasers;magnetic resonance imaging biomarker;Measures;Methods;Modeling;Movement;myocardial injury;Nervous System Physiology;Neurologic;Neurological outcome;neuron loss;Neuronal Injury;novel therapeutics;Organ;organ injury;Output;Patients;Performance;Perfusion;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;Pilot Projects;porcine model;prevent;Public Health;rearrest;renal artery;Renal function;Research;research study;Resuscitation;Series;Shapes;Shock;standard of care;survival outcome;Technology;Testing;Tissues;Titrations;Transesophageal Echocardiography;Translational Research;translational study;Trauma;United States;Urine;vasoconstriction;Ventricular Fibrillation;Work

PROJECT_TITLE: Endovascular blood pressure targeting in cardiac arrest, a translational research study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Biologic drugs have transformed the treatments of a variety of diseases, including diabetes, cancer, and heart disease, but they require injection into the body since these molecules are too large to easily diffuse through the tissue walls. Even though local administration of drugs is becoming increasingly necessary to provide therapeutic efficacy, no research or tools exist on understanding the flow of fluid into tissue. In this proposal, we will develop a computational model capable of predicting macromolecule drug distributions in tissue following an injection and a clinically translatable injection system that optimizes and standardizes injections into heart and tumor tissue.

PI_NAMEs: ABRAMSON, ALEX  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Area;Biological;Blood Vessels;cancer cell;Caring;Characteristics;Circulation;clinical translation;Computer Models;cytokine;Diabetes Mellitus;Diffuse;Diffusion;Disease;drug distribution;Drug Implants;fluid flow;gastrointestinal;Generations;Health Professional;Healthcare Systems;Heart;Heart Diseases;Heart Neoplasms;Immunotherapy;Injections;interfacial;Length;macromolecule;Malignant Neoplasms;Manuals;Mechanics;meter;Modeling;Mucous Membrane;Muscle;Myocardial;Myocardial Infarction;Needles;Neoplasm Metastasis;Oral Administration;Penetration;Pharmaceutical Preparations;Physiological;pressure;prevent;Property;Pump;Research;side effect;Solid Neoplasm;Standardization;Subcutaneous Injections;success;System;Therapeutic Effect;Tissue Engineering;Tissues;tool;Treatment Efficacy;Tumor Tissue;uptake;wound healing

PROJECT_TITLE: Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

PHR: Project Narrative Initiatives such as the National Plan to Address Alzheimer's Disease (AD) call for greater attention to increasing enrollment into clinical trials and other clinical research; an outgrowth of the National Plan is the National Strategy for Recruitment and Participation in Alzheimer's Disease Clinical Research which enumerated four goals, one of which is focused specifically on the need to “build and improve research infrastructure of registries in order to recruit and retain more and more diverse qualified study participants.” The objective of this proposal is to develop, deploy, optimize and automate new website design/content, infrastructure and functionality to support and sustain online recruitment, engagement, and retention of adults interested in participating in AD-focused studies, creating a sustainable and enduring resource to researchers by building off of our successful Alzheimer's Prevention Registry (APR), an online registry launched in 2012 with >350,000 members, including ~90,000 enrolled in its GeneMatch (GM) program launched in 2015.

PI_NAMEs: LANGBAUM, JESSICA BROOKE (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Alzheimer disease prevention;Alzheimer's Disease;Attention;Caring;Clinical Research;Clinical Treatment;Clinical Trials;Communication;dashboard;Data;Databases;design;Electronic Mail;Eligibility Determination;eligible participant;Enrollment;Ensure;evidence base;experience;Feedback;Funding;Future;Goals;Grant;improved;Individual;Information Technology;Infrastructure;Institutional Review Boards;interest;Intervention;Medical;member;Methods;Monitor;Newsletter;older adult;online registry;Participant;Patient Recruitments;Persons;Population Heterogeneity;prevent;Prevention trial;Process;programs;Public Health;Qualifying;Questionnaires;recruit;Registries;Research;Research Infrastructure;Research Personnel;Resources;screening;Secure;Security;Site;Surveys;technology platform;Text Messaging;Time;Underrepresented Populations;United States;Update;web site

PROJECT_TITLE: Optimizing Research Infrastructure of Registries to Accelerate Participant Recruitment into Alzheimer's Focused Studies

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Hematology;Infectious Diseases;Sepsis;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Alcohol use disorder is reported in 1/8th critically ill patients. Sepsis kills more than 250,000 patients in the US each year and alcohol use disorder is independently associated with increased mortality with sepsis. Results from this research may improve our understanding of how alcohol consumption increases mortality in sepsis and develop novel therapies to treat sepsis.

PI_NAMEs: VACHHARAJANI, VIDULA  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acute;Adhesions;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Anti-Inflammatory Agents;Blood Vessels;Bone Marrow;Cell model;Cell Respiration;Cells;chemokine;Chronic;Citric Acid Cycle;Co-Immunoprecipitations;cohort;Coupling;Critical Illness;cytokine;Data;Enzymes;Ethanol;experimental study;Extravasation;Family;fatty acid oxidation;feeding;fitness;Functional disorder;Genetic;Genetic Transcription;Glucose;Glycolysis;Goals;Growth;healthy volunteer;Human;Immune;Immune response;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-10;Knock-out;Leukocytes;Lipopolysaccharides;loss of function;Macrophage;MAP Kinase Gene;Mass Spectrum Analysis;member;Membrane;Membrane Potentials;Metabolic;Metabolism;metabolomics;Microcirculation;Mitochondria;Molecular;Monitor;mortality;mouse model;Mus;Myelogenous;novel therapeutics;Obesity;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Peritoneal;Peritoneal Macrophages;Phagocytosis;pharmacologic;Phase;Phenotype;Plasma;polymicrobial sepsis;Post-Translational Protein Processing;Proteins;Reporting;Repression;Research;Respiration;response;Ribosomal RNA;Risk Factors;Role;Sepsis;septic patients;Sirtuins;Survivors;targeted treatment;Testing;therapeutic target;Tissues;translational potential

PROJECT_TITLE: Immuno-metabolic dysfunction in alcohol with sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Adult hippocampal neurogenesis is a unique form of brain plasticity important in certain forms of learning, memory and mood regulation; aspects of brain function that are dysregulated in fetal alcohol spectrum disorders (FASDs). Here, we will investigate adult neurogenesis as a therapeutic target in a mouse model of prenatal alcohol exposure, which may lead to new avenues for improving treatment in FASD.

PI_NAMEs: CUNNINGHAM, LEE ANNA (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adult;adult neurogenesis;Affect;alcohol exposure;Animal Experiments;anti-depressive agents;Behavior;Behavioral;behavioral response;Brain;Clinical;clinical diagnosis;Cognition;Cognitive;cognitive task;Complex;Data;design;Development;Discrimination;Discrimination Learning;drinking;Electrophysiology (science);emerging adult;Emotional;Environment;environmental enrichment for laboratory animals;Equation;Experimental Models;experimental study;Exposure to;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;flexibility;Fluoxetine;gain of function;Gene Expression;Genetic;Goals;granule cell;Hippocampus;House mice;Human;Immediate-Early Genes;Impairment;improved;indexing;Individual;Intellectual functioning disability;Intervention;Label;Laboratories;Learning;Life;Mediating;Memory;Mental Health;Methods;Modeling;mood regulation;Moods;Morphology;mouse model;Mus;Nervous System Disorder;Neuroanatomy;neurochemistry;neurogenesis;Neurological outcome;Neuronal Plasticity;Newborn Infant;Outcome;Pattern;Performance;pharmacologic;pre-clinical;progenitor;Publications;Rabies;Reporting;Research;response;Rodent Model;Role;Saccharin;stress resilience;Synapses;Testing;Therapeutic;therapeutic target;Training

PROJECT_TITLE: Network mechanisms of impaired adult hippocampal neurogenesis in a mouse model of prenatal alcohol exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Multiple myeloma (MM) is an incurable hematopoietic malignancy that progresses from benign monoclonal gammopathy precursor conditions. Oncogenic mutations in MM are similar to those found in the precursor conditions, and it is not clear what ultimately drives tumorigenesis. Understanding these mechanisms may lead to the development of therapeutic strategies to prevent cancer development in these patients.

PI_NAMEs: ANDERSEN, THOMAS LEVIN GEISER;DRAKE, MATTHEW T;WEIVODA, MEGAN M (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Ablation;Acute;Age;Aging;aging mechanism;Area;Automobile Driving;Benign;Benign Monoclonal Gammopathies;Biopsy;bone;Bone Marrow;Cell Aging;Cell Senescence Induction;cell transformation;Cells;Cellular Stress;Characteristics;Chromosome abnormality;Clinical Trials;Clonal Evolution;Data;Data Set;Development;Diagnosis;Disease Progression;DNA;DNA Transposable Elements;Evaluation;Exhibits;Gene Deletion;Gene Expression;Gene Mutation;Genes;Genetic;Genomic Instability;Goals;Growth;Hematologic Neoplasms;Hematopoietic Neoplasms;Human;Hybrids;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Interferons;Malignant Neoplasms;Mediating;Methylation;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;mouse model;Multiple Myeloma;Mus;Mutation;neoplastic cell;Nucleic Acids;Obesity;old mice;Oncogene Activation;Oncogenes;Oncogenic;Pathology;Patients;permissiveness;pharmacologic;Phenotype;Plasma Cell Neoplasm;Plasma Cells;Precancerous Conditions;premalignant;prevent;promoter;response;Risk Factors;RNA;Role;senescence;senescence associated secretory phenotype;senescent cell;Single-Stranded DNA;Stains;success;Techniques;Testing;therapeutic development;tool;Translating;tumor;tumorigenesis;tumorigenic;United States

PROJECT_TITLE: Role of senescence in multiple myeloma tumorigenesis


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The University of Colorado Anschutz Medical Campus Computational Bioscience Program (CPBS) is an independent, Ph.D.-granting and postdoctoral training program based in the University of Colorado School of Medicine, with a 20-year track record of innovative and effective training of pre- and post-doctoral fellows for research careers. We are a second-generation biomedical informatics teaching program, informed by the experience of the many training models that have come before us. Our program is designed to produce graduates with depth in both computational methods and biomedicine, an intimate familiarity with the science and technology that synergizes the two, and the skills necessary to pioneer novel computational approaches to significant biomedical questions.

PI_NAMEs: KECHRIS-MAYS, KATHERINA ;KRISHNAN, ARJUN  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Adopted;Awareness;Behavior;Bioethics;Biological Sciences;biomedical informatics;career;Categories;Clinical Research;Colorado;Communication;computer science;Computing Methodologies;Curiosities;design;Development;Discipline;Doctor of Philosophy;Education;Educational process of instructing;Ethics;experience;Familiarity;flexibility;Generations;Goals;Grant;Habits;high standard;improved;informatics training;innovation;insight;Knowledge;life-long learning;Medical;medical schools;Modeling;novel;novel strategies;Oral;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Research;Science;Scientist;Self Direction;skills;statistics;Structure;Students;synergism;Technology;Time;Training;Training Programs;Translational Research;Universities;Work;Writing

PROJECT_TITLE: Colorado Biomedical Informatics Training Program


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Behavioral weight loss interventions for obesity reliably result in weight loss and health benefits. However, the extent of weight loss they produce is typically limited to ~7–10% of total body weight and weight regain is common, limiting their ability to modify disease risk in a sustained manner. To address these limitations, the proposed research seeks novel mechanisms underlying the changes in appetite and metabolism that contribute to the occurrence of involuntary weight loss plateaus in free-living participants undergoing a behavioral weight loss intervention.

PI_NAMEs: NEUHOUSER, MARIAN L;SCHUR, ELLEN A (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adult;Behavior assessment;Behavior Therapy;Behavioral;Bioenergetics;Biological;Biology;Biopsy;Blood Cells;Blood specimen;Body Weight;Body Weight decreased;Brain;brain magnetic resonance imaging;Brain region;Clinical Research;Data;design;Desire for food;Diet;disorder risk;Eating;Eating Behavior;Energy Metabolism;experimental study;Fasting;Functional Magnetic Resonance Imaging;Future;Goals;Health;Health Benefit;Hormones;Human;human tissue;Impairment;improved;increased appetite;Indirect Calorimetry;Individual;innovation;Intervention;Investigation;Knowledge;Liquid substance;Literature;Maintenance;Measures;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Monitor;Motivation;multidisciplinary;Muscle;Neurologic;neurophysiology;novel;novel strategies;Obesity;Obesity associated disease;obesity treatment;Outcome;Outcome Assessment;Overweight;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;personalized approach;Phase;Phenotype;Physiological;Physiological Adaptation;Physiology;Pre-Clinical Model;Predictive Factor;real time monitoring;Reliability of Results;remote delivery;remote monitoring;Research;respiratory;response;Rest;Rewards;Satiation;Satiety Response;Skeletal Muscle;Specimen;Structure;Technology;Testing;Time;Tissue Sample;Tissues;Visit;Weight;weight loss intervention;weight maintenance;Work

PROJECT_TITLE: Physiological changes underlying the weight loss plateau in humans

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Kidney Disease;Precision Medicine

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The KPMP Kidney Tissue Atlas is a unique resource that will form the foundation for precision medicine for the kidney health community. Our tissue interrogation site has established the critical need for localizing molecules linked to metabolism at a spatial level to identify pathways critical for disease understanding. With the next phase of KPMP, we have added new expertise, improved spatial resolution, greater coverage and deep pathway interpretative ability to bring forth new biomarkers and support precision therapeutics.

PI_NAMEs: ALEXANDROV, THEODORE ;ANDERTON, CHRISTOPHER R;SHARMA, KUMAR  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Ablation;Acute Renal Failure with Renal Papillary Necrosis;Bioinformatics;Biological Markers;Biology;Cells;Chronic Kidney Failure;clinically relevant;cloud software;Collaborations;Community Health;COVID-19 impact;COVID-19 pandemic;Critical Pathways;Data;Data Collection;data integration;data management;data resource;data sharing;data visualization;Detection;Diabetic Nephropathy;Disease;Disease Progression;disorder subtype;drug metabolism;Equipment and supply inventories;European;experience;FAIR principles;Foundations;Funding;Genes;Goals;Health;high throughput analysis;Human;hypertensive;Image;improved;instrumentation;integration site;ionization;Kidney;kidney biopsy;Kidney Diseases;kidney metabolism;knowledge integration;Laboratories;Lasers;Link;lipidomics;Lipids;Maps;mass spectrometric imaging;medical schools;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;meter;Methods;Molecular;Molecular Biology;molecular imaging;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;optical imaging;Pacific Northwest;Pathology;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Polysaccharides;Positioning Attribute;precision medicine;Precision therapeutics;Probability;programs;Proteins;Resolution;Resources;Sampling;scale up;Sensitivity and Specificity;Site;Source;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Technology;Texas;Time;Tissue atlas;Tissues;Universities;Update;Visualization;Visualization software

PROJECT_TITLE: Spatial Multi-Omics to Profile Metabolic Pathways for Kidney Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Swallowing problems in Alzheimer’s disease cause significant health and quality of life issues. This translational research establishes whether tongue exercise started earlier or later in the disease process significantly improves swallowing function and changes AD-related pathology in tongue muscles and associated brain regions.

PI_NAMEs: CIUCCI, MICHELLE RENEE;CONNOR, NADINE P (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta oligomer;Address;Adherence;Affect;Age Months;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloidosis;Analysis of Covariance;Aspiration Pneumonia;Behavior;Behavioral;Behavioral Assay;behavioral impairment;Biochemistry;Bioenergetics;Biological;Biological Assay;Bite;Bolus Infusion;Brain;Brain Pathology;Brain region;Brain Stem;Caregiver Burden;Caring;Central Nervous System;Characteristics;Clinical;clinical practice;Clinical Protocols;Clinical Trials;clinically relevant;comorbidity;Controlled Study;cost;Data;Degenerative Disorder;Deglutition;Deglutition Disorders;design;Disease;Disease Progression;Early Intervention;Effectiveness;Evidence based treatment;Exercise;exercise intervention;Experimental Designs;Female;functional decline;Functional disorder;Future;Gliosis;Goals;Health;Healthcare Systems;High Prevalence;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;in vivo;Inflammation;inflammatory marker;innovation;insight;Intake;Intervention Studies;Knowledge;Laboratories;Link;Logistic Regressions;male;Mastication;Measures;microPET;Modeling;Morphology;Motor;Muscle;Muscle function;muscular structure;muscular system;neural;Neurobiology;neuroimaging;neuron loss;novel;Oral;Oropharyngeal;Outcome;Parkinson Disease;Pathologic;Pathology;Peripheral;Peripheral Nervous System;Personal Satisfaction;Persons;Phosphorylation;Physiological;Physiology;Polymerase Chain Reaction;Population;Positioning Attribute;pre-clinical;Preparation;Prevalence;prevent;Prevention;Process;Property;Quality of life;Randomized;Rattus;Rehabilitation therapy;Research;Signs and Symptoms;skeletal;Structure;System;tau Proteins;tau-1;Testing;Tissues;Tongue;Translating;translational approach;Translational Research;treatment optimization;Work

PROJECT_TITLE: Mechanisms of swallowing dysfunction and rescue in a translational rat model of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Alcohol intoxication leads to the impairment of cerebellar-dependent tasks, with those in the motor control domain attracting the most interest due to the potential dangers associated with impaired motor coordination. In chronic alcoholics alterations in cerebellar function persist in the absence of alcohol consumption, but, while the molecular mechanisms underlying the effects of acute alcohol exposure on cerebellar physiology have been extensively investigated, the effects of chronic alcohol exposure on the cerebellum is understudied. The experiments outlined in this K01 application tackle this long standing gap in the alcohol research field using a well-established mouse model of alcohol dependence combined with ex-vivo electrophysiology, dendrite and spine morphology analysis and epigenetic research methods.

PI_NAMEs: ZAMUDIO-BULCOCK, PAULA ANDREA (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;addiction;Adult;Affect;Aging;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcoholic Intoxication;Alcohols;Animal Model;Animals;Area;Behavioral;binge drinking;Brain;Brain region;career development;Cell Physiology;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Chemicals;Chronic;chronic alcohol ingestion;Confocal Microscopy;Consumption;Decision Making;Dendrites;Dendritic Spines;density;Dependence;Development;Diet;drinking;Electrophysiology (science);Enzymes;Epigenetic Process;Ethanol;Ethanol dependence;experience;experimental study;Exposure to;Female;Fiber;Foundations;functional adaptation;Functional disorder;Gene Expression;Genome;Histone Acetylation;histone methylation;histone modification;Human;Impairment;Institution;interest;Interneurons;Intoxication;Label;Laboratories;Lead;Learning;Lobular;Lobule;male;Manuscripts;Measures;Mentored Research Scientist Development Award;Mentors;Methodology;Midbrain structure;Modeling;Modification;Molecular;Morphology;motor control;motor impairment;mouse model;Mus;Neonatal;neuronal survival;Neurons;neurotransmission;Output;patch clamp;Physiology;prenatal;prenatal exposure;Preparation;Presynaptic Terminals;problem drinker;Process;Professional Competence;Proteins;Purkinje Cells;Reporting;Research;Research Methodology;Research Personnel;Rewards;Rodent;skills;Slice;Solid;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;therapeutic target;Time;Training;Training Activity;ultra high resolution;vapor;Vertebral column

PROJECT_TITLE: Functional, Structural and Epigenetic Modifications of Cerebellar Purkinje Neurons in Alcohol-Dependent Mice


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The triple-negative breast cancers (TNBCs) are highly aggressive and recurrent. Targeted therapy and combined chemo-immunotherapy have great potential to treat metastatic and heterogenous TNBCs. This project will develop and fully evaluate a humanized anti-CD276 antibody-drugs conjugate (Hu276-DualADC), which carries both highly potent payload to kill cancer cells and toll-like receptor agonist to activate effector immune cells in tumor microenvironment, and in combination with PD-1-targeted ADC for TNBCs treatment.

PI_NAMEs: CARSON, WILLIAM E.;LIU, XIAOGUANG MARGARET (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 4T1;Affinity;Agonist;angiogenesis;Animal Model;anti-cancer;anti-PD-1;anti-PD1 antibodies;Antibody-drug conjugates;Apoptosis;Binding;Biodistribution;Breast;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer subtypes;cancer therapy;CD276 gene;Cell Death;cell killing;Cells;chemotherapy;Circulation;Clinic;Clinical Trials;clinically relevant;Combined Modality Therapy;confocal imaging;CTLA4 gene;cytokine;cytotoxic;Cytotoxic Chemotherapy;cytotoxicity;Data;Development;Distant;dosage;Drug Kinetics;Drug resistance;effective therapy;effectiveness evaluation;efficacy study;Engineering;Evaluation;Event;Excision;Extracellular Domain;Flow Cytometry;Future;glycosylation;Goals;Heterogeneity;high dimensionality;Histopathology;Human;humanized mouse;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune checkpoint blockers;immune function;Immune Tolerance;Immuno-Chemotherapy;Immunocompetent;Immunohistochemistry;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Infiltration;innovation;Interferon Type II;Invaded;Investigation;Laboratories;Macrophage;Malignant Neoplasms;Maximum Tolerated Dose;MDA MB 231;Mediating;Medical;Membrane;Membrane Glycoproteins;Microtubules;Modeling;Monoclonal Antibodies;mouse model;Names;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Operative Surgical Procedures;optimal treatments;Organ;Pathology;patient derived xenograft model;Patients;pembrolizumab;Pharmaceutical Preparations;Pharmacotherapy;phase III trial;pre-clinical;pre-IND studies;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteomics;Quality of life;Radiation therapy;Receptor Activation;Recurrence;Refractory;Relapse;Resistance;response;restoration;Specificity;standard of care;Surface;Survival Rate;synergism;systemic toxicity;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Tissue Microarray;Tissues;TLR1 gene;TLR7 gene;TNF gene;Toll-like receptors;Toxic effect;Toxicology;Transcript;Translations;Treatment Efficacy;Treatment Protocols;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Dual-payload antibody-drug conjugate for chemo-immunotherapy of triple-negative breast cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the most cost-effective strategy to prevent new HIV infections, and more effective when combined with antiretroviral therapy (ART). We propose to use the Network for the Improvement of Addiction Treatment (NIATx) implementation strategy to scale-up OAT in three diverse Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan) and guided by the Exploration-Planning-Implementation-Sustainment (EPIS) framework. Understanding the trajectories of implementation and scale-up in this context may emerge through creating communities of practice, especially when cohesion and competence evolves, and may guide other healthcare delivery challenges in the region (e.g., HIV, TB); as well as build important regional expertise and understanding implementation trajectories should help support OAT program sustainability.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact);MADDEN, LYNN

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: addiction;Address;Adoption;Advocacy;AIDS prevention;antiretroviral therapy;Asian;Central Asia;Characteristics;Client;Clinic;clinical care;cohesion;Combined Modality Therapy;Community of Practice;Competence;contextual factors;cost effective;Country;Detection;Economics;Elements;Epidemic;Evidence based practice;experience;Goals;Growth;Health;Health Benefit;health care delivery;Health Policy;Health system;Healthcare;Healthcare Systems;HIV;HIV Infections;implementation barriers;implementation efforts;implementation strategy;improved;Injecting drug user;innovation;International;Kazakhstan;Kyrgyzstan;Learning;medication-assisted treatment;meetings;member;Modeling;Opioid;opioid agonist therapy;opioid epidemic;opioid use disorder;Outcome;Patients;Policies;Politics;Preparation;prevent;Primary Prevention;Process;Program Sustainability;programs;Provider;Public Health;Research;Resources;Route;scale up;Secondary Prevention;Sexual Partners;structural determinants;success;Tajikistan;Techniques;tool;Training;Ukraine;USSR;Viral

PROJECT_TITLE: Expanding Medication Assisted Therapies in Central Asia

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Our ability to predict disease in solid organs is markedly hampered by the clinical impracticability of routine biopsies for several organs. Here, we propose the use of a high dimensional atlas of circulating neutrophil transcriptomics as predictor of disease before signs and symptoms develop.

PI_NAMEs: OKWAN-DUODU, DERICK  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Abdomen;Abdominal Pain;Alzheimer's Disease;antimicrobial;Atlases;Award;Biopsy;Blood;Blood Cells;Blood Circulation;Brain;Brain imaging;Catalogs;cell injury;Cells;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;Circulation;Clinical;Code;Coronary Arteriosclerosis;Coupled;Cytometry;Detection;Diagnosis;Diagnostic;Digestion;dimensional analysis;Disease;disease model;Early Diagnosis;Early Intervention;early screening;Epitopes;Etiology;Eye;Fibrosis;flexibility;Foundations;Functional disorder;functional status;Gene Expression Profile;Genetic Screening;genetic testing;Genetic Transcription;genomic aberrations;Goals;Half-Life;Health;Heart;high dimensionality;Homeostasis;Human;human disease;Image;Immune;Immune response;improved;Individual;Infiltration;innovation;insight;Kidney;Laboratories;Link;Liver;Lung;Mediating;Memory;Modality;Modern Medicine;Morbidity - disease rate;mortality;Nephritis;Nephrosis;Nephrotic Syndrome;neutrophil;Neutrophil Infiltration;novel;Organ;Pancreas;Pathologic;Penetrance;Preventive measure;Proteins;Pulmonary Fibrosis;Pulmonary function tests;Reporter;residence;Respiratory Failure;Sampling;Scanning;screening;Sentinel;Signs and Symptoms;single-cell RNA sequencing;Solid;Stroke;Symptoms;System;Testing;Therapeutic Intervention;Time;Tissues;transcriptomics;United States

PROJECT_TITLE: High dimensional atlas of circulating neutrophils as reporters of solid organ functional status

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cardiovascular;Cerebrovascular;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Substance Misuse

ORG_CITY: SHREVEPORT

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Hong Sun, MD, PhD PROJECT NARRATIVE Light alcohol consumption not only lowers the occurrence of ischemic stroke but also improves the outcome of ischemic stroke in people with risk factors for cardiovascular disease. We aim to develop novel strategies for the prevention and treatment of ischemic stroke by uncovering how alcohol alters the occurrence and outcome of ischemic stroke. Studies planned in this renewal application will focus on light alcohol consumption-induced generation of new blood vessels and neurons in the brain.

PI_NAMEs: SUN, HONG  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Address;Adult;Alcohol consumption;alcohol exposure;Alcohols;American;angiogenesis;Blood Vessels;Brain;brain endothelial cell;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Central Nervous System;Cerebral Ischemia;Cerebrum;Chronic;clinical care;cognitive function;Dependovirus;deprivation;DNA Binding;Doctor of Philosophy;Generations;Genetic Suppression;Glucose;Goals;Grant;Human;improved;improved outcome;Incidence;Individual;Ischemic Stroke;KDR gene;Lifelong disability;Ligands;Light;light effects;man;Mediating;Middle Cerebral Artery Occlusion;Molecular;Mus;nerve stem cell;neurogenesis;Neurons;neuroprotection;novel strategies;Nuclear;Outcome;Oxygen;Persons;pharmacologic;PPAR gamma;prevent;Prevention strategy;Prognosis;Prostaglandin D2;Reperfusion Injury;Reperfusion Therapy;response;Risk;Risk Factors;Rodent;Signal Transduction;Stroke prevention;stroke therapy;Testing;Translating;Translations;Up-Regulation;VEGFA gene;Weight

PROJECT_TITLE: Light Alcohol Consumption and Ischemic Stroke

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Lung

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The goal of this project is to define mechanisms of immunity and pathogenesis of human metapneumovirus (HMPV), a leading cause of lung infections. We found that virulent strains of HMPV induce types I and III interferon, which exhibit discordant roles in protection and disease. The knowledge gained from these experiments will guide develop of therapeutics and vaccines for HMPV and will increase our understanding of how interactions between respiratory viruses and the immune system contribute to disease and protection.

PI_NAMEs: WILLIAMS, JOHN V. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: adaptive immune response;Address;Adult;Amino Acid Motifs;Amino Acids;Anti-viral Therapy;Asthma;Attenuated Vaccines;Automobile Driving;Biology;Blocking Antibodies;Cells;cellular targeting;Cessation of life;Child;Childhood;Chimera organism;chimeric gene;Chronic Obstructive Pulmonary Disease;Clinical;comorbidity;conditional knockout;Confocal Microscopy;cytokine;Data;defined contribution;Disease;early childhood;Epithelial Cells;Exhibits;experimental study;Family;Gene Modified;Genes;Genome;Goals;Health;HIV;Hospitalization;Human;Human Metapneumovirus;Hydrophobic Interactions;Hydrophobicity;IFNAR1 gene;Immune;Immune signaling;Immune system;Immunity;Immunobiology;In Vitro;in vivo;Individual;Infection;innate immune mechanisms;Interferon Suppression;Interferon Type I;Interferons;Interleukin-6;Knockout Mice;Knowledge;Life;Lower Respiratory Tract Infection;Lower respiratory tract structure;Lung;Lung infections;Mediating;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Natural Immunity;new therapeutic target;older adult;Paper;Paramyxovirus;Pathogenesis;Pathology;Patients;Persons;Phenotype;Phosphorylation;Pneumovirus;premature;Prevention;Proteins;Publishing;receptor;Research;Respiratory syncytial virus;respiratory virus;response;reverse genetics;Role;Shapes;Signal Transduction;STAT1 gene;STAT2 gene;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic vaccine;TNFRSF1A gene;tool;Transfection;Vaccines;Viral;Viral Proteins;Virulence;Virulent;Virus;Virus Replication;virus small hydrophobic protein;Work

PROJECT_TITLE: Host Determinants of Human Metapneumovirus Immunity and Pathogenesis

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Immunotherapies hold immense potential to provide cures for many cancers and metastatic disease, but the complexity of activating and sustaining anti-tumor immune responses will necessitate combinatorial treatment regimes and a better understanding of how the tumor microenvironment (TME) affects response. Here we develop a in vitro model of the tumor-immune circuit which allows precise control over spatial, molecular, cellular, and mechanical aspects of the TME that affect response to immunotherapy, and use it for both mechanistic studies as well as high-throughput predictive screening of immune therapies in a tumor- or patient- specific manner.

PI_NAMEs: SWARTZ, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Adverse event;Affect;anti-tumor immune response;Binding;Biological Models;Biomechanics;Breast Cancer Model;cancer immunotherapy;cancer type;cell killing;cell type;Cells;Characteristics;chemokine;Chemosensitization;chimeric antigen receptor T cells;Collaborations;Collagen;Combination immunotherapy;combinatorial;Communication;Complement;Complex;cost;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Development;Devices;Disease;draining lymph node;Engineering;Environment;Exclusion;Exhibits;experimental study;extracellular;Extracellular Matrix;Face;flexibility;Goals;high throughput screening;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;immunotoxicity;improved;In Situ;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;insight;interest;interstitial;Leukocytes;Lymph;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Malignant Neoplasms;Maps;Mechanics;Mediator;Melanoma;Metastasis Suppression;Minority;Modeling;Molecular;Morphology;mouse model;Mus;Nature;neoantigens;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;novel therapeutic intervention;Outcome;parallelization;Patients;Perfusion;personalized approach;Play;pre-clinical;Predictive Value;Primary Neoplasm;Process;Pump;response;Role;screening;Signal Transduction;spatial relationship;Stratification;System;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;tool;Transfection;tumor;tumor heterogeneity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Vascular Endothelial Growth Factor C

PROJECT_TITLE: Probing cellular, molecular and biomechanical barriers to immunotherapy in the tumor microenvironment with organotypic in vitro models of the tumor-lympho-immune interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DOYLESTOWN

ORG_NAME: FOX CHASE CHEMICAL DIVERSITY CENTER, INC

PHR: Alzheimer’s disease (AD) is the most common cause of mid- to late-life cognitive impairment and dementia, afflicting ~30 million people worldwide. TDP-43-associated AD (AD-TDP), also called Limbic-predominant Age- related TDP-43 Encephalopathy or LATE, is a recently recognized AD subtype that may be treatable with TDP- 43 targeted therapy. We are developing small molecule inhibitors of nucleic acid binding to TDP-43, which are also TDP-43 aggregation inhibitors, showing therapeutic-like effects in three biological models, to treat AD- TDP and related disorders.

PI_NAMEs: REITZ, ALLEN BERNARD (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Accounting;acronyms;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Amino Acids;Amyotrophic Lateral Sclerosis;Animal Model;aqueous;attributable risk;Binding;Binding Proteins;Biological Assay;Biological Models;Brain;Brain region;C-terminal;C9ORF72;Caco-2 Cells;Canis familiaris;Cell Line;Cells;Clinical;clinical development;clinical diagnosis;Clinical Trials;Crystallography;Cytochrome P450;cytotoxicity;Data Correlations;Dementia;Development;Disease;disorder subtype;DNA-Binding Proteins;Docking;Dose;Drosophila genus;Drug Industry;Encephalopathies;epidemiologic data;Evaluation;fluorodeoxyglucose positron emission tomography;Frontotemporal Lobar Degenerations;Genetic Transcription;Glycine;Half-Life;Human;human model;Image;imaging study;Impaired cognition;improved;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;Industry Standard;inhibitor;late life;Libraries;Ligand Binding;Ligands;light scattering;limbic-predominant age-related TDP-43 encephalopathy;Liver Microsomes;locomotor deficit;Mammalian Cell;Measures;Metabolic;Metabolic Marker;Modeling;Motor Neurons;mouse model;Mus;mutant;new chemical entity;novel;Nucleic Acid Binding;nucleic acid binding protein;nucleic acid inhibitor;older adult;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Penetration;Permeability;Persons;Pharmaceutical Preparations;Phase;Plasma;Plasma Proteins;Play;Polymorph;Positron-Emission Tomography;preclinical development;prevent;prion-like;promoter;Property;protein function;protein TDP-43;Proteins;Public Health;Rattus;Regulator Genes;response;Ribonucleotides;RNA Binding;Rodent;Roentgen Rays;Role;RRM1 gene;RRM2 gene;Safety;scale up;small molecule;small molecule inhibitor;Sodium Chloride;Solubility;Spliced Genes;stability testing;Statistical Data Interpretation;Syndrome;targeted treatment;TDP-43 aggregation;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Toxic effect;Toxicity Tests;Toxicology;Transfection;X-Ray Crystallography

PROJECT_TITLE: Therapeutics targeting TDP-43 to treat Alzheimer's disease and related disorders


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We propose to provide new evidence on the relationship between parental income and children's mental and physical health and well-being through the Y Combinator Research (YCR) Basic Income randomized controlled trial, which will randomly assign 1000 individuals to receive $1000 per month of supplemental income, with a control group receiving $50 per month, for three years. We will survey participants about their children's physical and mental health, development, prosocial behavior, stress, household environment, parental relationships, food security, expenditures on activities and enrichment, and access to and use of medical care. Our study will provide new, timely, and policy-relevant estimates on the impact of parental income on child health and well-being and the mechanisms through which this relationship operates.

PI_NAMEs: MILLER, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Accident and Emergency department;Achievement;Adult;Affect;Age;Aptitude Tests;Basic Science;Behavior;Caring;Child;Child Development;Child Health;Child Mental Health;Child Rearing;Child Welfare;Childhood;cognitive development;Conflict (Psychology);Control Groups;Data;Data Set;Development;Economics;Education;Educational Status;Emotional;Environment;Expenditure;experience;experimental study;Family;food security;genetic makeup;Health;Health Benefit;health disparity;health economics;health knowledge;Healthcare;Home environment;Hospitals;Household;Hyperactivity;inattention;Income;Individual;Inequality;intergenerational;Investments;Life;Life Cycle Stages;Life Expectancy;Low income;Measures;Medical;Mental Health;Modeling;Nature;Neighborhoods;Outcome;Parent-Child Relations;Parenting Education;Parents;Participant;Pathway interactions;Pattern;peer;Performance;Personal Satisfaction;physical conditioning;Policies;Policy Maker;Public Health;Quasi-experiment;Random Allocation;Randomized;Randomized, Controlled Trials;Research;Resources;Socioeconomic Status;Stress;Surveys;transmission process;treatment group

PROJECT_TITLE: Experimental Evidence on the Impact of Parental Income on Child Health and Well Being

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Contraception/Reproduction;Health Services;Infertility;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE One in eight women in the United States have infertility. In-vitro fertilization (IVF) is an effective treatment but can lead to high-risk twin, triplet, and higher-order multiple births. The proposed research is relevant to public health because it addresses unanswered questions about the impact of insurance coverage for IVF on the health of women and infants, and results from this study will provide patients, employers, and policymakers with actionable knowledge that will help them make evidence-based decisions about insurance coverage for IVF.

PI_NAMEs: DUPREE, JAMES M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adverse event;Affect;Age;age group;aged;Birth;Birth Rate;Categories;Childbirth;cost;Data;Disease;effective therapy;Embryo;Event;evidence base;Exclusion;experience;Fertilization in Vitro;Financial Hardship;financial incentive;Goals;Health;health care service utilization;Health Expenditures;Health Insurance;Health Policy;Healthcare Systems;Hemorrhage;high risk;hospital readmission;improved;Incentives;Incidence;Income;Infant;Infant Health;infant morbidity;infant morbidity/mortality;Infertility;infertility treatment;innovation;Insurance;Insurance Coverage;Knowledge;Left;Length of Stay;Maternal Age;Maternal Health;maternal morbidity;Mothers;multidisciplinary;Multiple Birth Offspring;Neonatal Intensive Care Units;novel strategies;Outcome;Patient Transfer;Patients;Perinatal;Policies;Policy Maker;Population;Premature Birth;psychologic;Public Health;Reporting;reproductive;Research;Research Personnel;Risk;Sampling;Serious Adverse Event;stem;Surveys;Testing;Time;Triplet Multiple Birth;Twin Multiple Birth;Uninsured Medical Expense;United States;Woman;Women's Health;women's outcomes;Work;young woman

PROJECT_TITLE: Quantifying the Impact of Insurance Coverage for IVF on Maternal and Infant Health

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Rehabilitation;Substance Misuse

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Narrative: Opioid Use Disorder (OUD) is a worsening problem, particularly in West Virginia, and current treatment methods are only about 50% effective. Deep Brain Stimulation (DBS) is a procedure that implants an electrical device in the brain and uses low electrical currents to change brain pathways. For this proposal, a DBS device will be placed in the reward center of the brain to evaluate the impact on OUD.

PI_NAMEs: REZAI, ALI R (contact)

PROGRAM_OFFICER_NAME: BROWNING, JENNY RAYE

PROJECT_TERMS: Basal Ganglia;Behavior;Brain;brain pathway;Brain region;Cessation of life;Clinical Trials;cohort;Combined Modality Therapy;craving;Data;Deep Brain Stimulation;Devices;Dopamine;economic impact;Elements;Evaluation;executive function;experience;Explosion;fluorodeoxyglucose positron emission tomography;frontal lobe;glucose metabolism;Goals;Healthcare Systems;high risk;Implant;implantation;Implantation procedure;improved;improved outcome;Individual;Informal Social Control;Institutional Review Boards;Internal Capsule;Intervention;Investigation;Leadership;life history;Measurement;Medical;medication-assisted treatment;Mental disorders;Methods;Modality;Monitor;mortality;mortality risk;Movement Disorders;neurobehavioral;neuroimaging;novel;Nucleus Accumbens;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Overdose;overdose death;overdose risk;Parkinson Disease;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;Population;Positron-Emission Tomography;Prefrontal Cortex;procedure cost;prospective;psychosocial;Raclopride;Randomized;randomized, controlled study;Refractory;Resources;response;reward circuitry;Rewards;Safety;safety and feasibility;safety study;safety testing;Secondary to;standard care;standard of care;success;Surgeon;Titrations;Treatment outcome;United States Food and Drug Administration;West Virginia

PROJECT_TITLE: Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed work is to chemically optimize the small molecule lead compounds and develop them as potential therapies against different Ebola viruses.

PI_NAMEs: RONG, LIJUN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: analog;Animal Model;Anti-viral Therapy;antiviral drug development;Binding;Biological Assay;Bundibugyo virus;Characteristics;Chemicals;Clinic;Complex;cost;Death Rate;Democratic Republic of the Congo;Dose;Drug Kinetics;Ebola;Ebola Hemorrhagic Fever;Ebola virus;efficacy evaluation;Estrogen Receptors;Exhibits;forest;Glycoproteins;Goals;GP2 gene;GTPBP1 gene;guinea pig model;Human;In Vitro;in vivo evaluation;Incidence;Infection;inhibitor;Lead;lead optimization;Libraries;Life;Ligands;Maximum Tolerated Dose;Mediating;Medical;Mus;nonhuman primate;novel;Pharmaceutical Preparations;pre-clinical;pre-IND studies;Prevalence;Property;prophylactic;remote location;Reporting;Research;Resolution;Reston Ebola virus;Route;Safety;scaffold;scale up;Selective Estrogen Receptor Modulators;Series;side effect;small molecule;small molecule inhibitor;small molecule libraries;Structure;Sudan;Tamoxifen;Therapeutic;therapeutic candidate;therapeutic target;therapeutically effective;Toremifene;Toxicokinetics;Viral;Viral Hemorrhagic Fevers;Viral Pathogenesis;Virus;Virus Diseases;Work;Zoonoses

PROJECT_TITLE: Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: We will conduct studies to better understand the function of atrial macrophages in order to advance our long- term translational goal to one day develop macrophage-targeted therapeutics as a new option for atrial remodeling, fibrosis and atrial fibrillation. We will study the role of macrophages in a new mouse model of atrial remodeling that combines clinical risk factors using different cell and gene depletion strategies in combination with single-cell RNA-sequencing. The acquired mouse data will finally undergo rigorous examination for translatability to humans using patient samples.

PI_NAMEs: HULSMANS, MAARTEN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Age;antagonist;Anticoagulation;Arrhythmia;Atrial Fibrillation;Atrial Function;Attenuated;Bone Marrow;Bone Marrow Transplantation;Brain;Cardiac;Cardiac Output;Cardiac Surgery procedures;Cardiovascular system;Cells;Clinical;clinical risk;clinically relevant;Coagulation Process;Collagen;combat;Complement;Computational Biology;Computing Methodologies;Data;Data Set;Deposition;Deterioration;Disease;Echocardiography;Elderly;Electrophysiology (science);Endothelium;experimental study;Fibroblasts;Fibrosis;gain of function;Gene Deletion;Generations;Genes;Genetic;Goals;Growth;Heart;Heart Atrium;Heart failure;hemodynamics;Heterogeneity;Histologic;Histology;Human;human disease;Hypertension;Immunology;immunomodulatory therapies;In Vitro;in vivo;Incidence;Inflammatory;insight;Intestines;Knock-out;Laboratories;Left;Left atrial structure;Left Ventricular Remodeling;Leukocytes;loss of function;Macrophage;Maps;Marrow;Mitral Valve Insufficiency;monocyte;mouse model;multiphoton microscopy;Mus;novel;Obesity;Operative Surgical Procedures;Optics;Organ;osteopontin;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Play;pre-clinical;Preparation;Publishing;recruit;Research;Rest;Risk Factors;Role;Sampling;Science;second harmonic;Signal Transduction;single-cell RNA sequencing;small molecule;source localization;Stroke;targeted treatment;Testing;Therapeutic;Therapeutic Embolization;therapeutic evaluation;Time;Tissues;Transgenic Mice;translational goal;Transplantation;Ventricular;Work

PROJECT_TITLE: Macrophage heterogeneity in atrial remodeling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]