ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The lens is a complex tissue whose proper development requires the precise spatiotemporal induction of differentiation-specific gene expression and of organelle removal from the central light path to create a transparent tissue whose function is to focus images on the retina. We discovered an essential role in both these processes for the signal transduction molecule PI3K. In this grant we propose studies that will define the mechanisms by which PI3Ks govern the expression of genes that are critical to acquisition of the lens fiber cell phenotype as well as the PI3K-dependent pathways that regulate the loss of organelles from the center of the lens to form an organelle free zone (OFZ).

PI_NAMEs: KANTOROW, MARC ;MENKO, A. SUE (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: AKT inhibition;AKT Signaling Pathway;Anterior;ATAC-seq;Autophagocytosis;Binding;Binding Sites;Biological Assay;Catalytic Domain;Cell Differentiation process;Cell Nucleus;Cell Physiology;cell type;Cells;Chick Embryo;Chromatin;Complex;Consensus;Crystallins;Cytoplasm;Development;DNA;DNA Binding;Down-Regulation;EPHA2 gene;Epithelial Cells;Epithelium;Event;Excision;Exhibits;Family;fiber cell;Funding;FYCO1 gene;Gene Expression;Gene Expression Profile;gene induction;Genes;Genome;genome-wide;Golgi Apparatus;Grant;High-Throughput RNA Sequencing;Image;Individual;Investigation;lens;Lens development;Lens Fiber;lens induction;lens transparency;Light;Link;Maps;Microdissection;Mitochondria;MLLT7 gene;Modeling;Nuclear;Nuclear Translocation;Nucleic Acid Regulatory Sequences;Organ;Organelles;Pathway interactions;Pattern;Phenotype;Phosphorylation;PI3K/AKT;PIK3CG gene;Play;Process;programs;Regulation;Retina;Role;Signal Induction;Signal Pathway;Signal Transduction;spatiotemporal;Tissues;transcription factor;transcriptome sequencing;Undifferentiated

PROJECT_TITLE: Regulatory role of PI3K signaling pathways in lens differentiation and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cancer vaccines offer the possibility of stimulating the immune system to provide sustained protection against tumor growth. The main goal of this proposal is to develop an all-in-one peptide vaccine delivery system that provides targeted antigen and adjuvant delivery to professional antigen presenting cells. We anticipate that the proposed research will lead to an anti-cancer peptide antigen delivery system that is ready for rapid translation, while elucidating important fundamental mechanism questions for peptide antigen delivery.

PI_NAMEs: PUN, SUZIE H. (contact);STAYTON, PATRICK S.

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Acceleration;Address;Adjuvant;Amino Acid Sequence;anti-cancer;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Binding;Bioinformatics;Biological Assay;Breast Cancer Model;cancer immunotherapy;cancer prevention;cancer therapy;cancer type;Cancer Vaccines;Cancerous;CAR T cell therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Chemistry;Clinical;clinical development;clinical efficacy;Clinical Trials;combat;controlled release;Cross Presentation;Cytosol;Dendritic cell activation;Dendritic Cells;density;design;efficacy evaluation;Endosomes;Engineering;Epitopes;ERBB2 gene;Evaluation;Excretory function;extracellular;Formulation;Goals;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;immunogenic;Immunologic Stimulation;Immunologics;Immunooncology;Immunosuppression;Immunotherapy;improved;In Situ;In Vitro;in vivo;innovation;Integrated Delivery Systems;interest;Intravenous;Kinetics;Lead;Ligands;lymph nodes;lymphatic vessel;Malignant Neoplasms;Mammary Neoplasms;manufacture;Mediating;Melanoma;Modeling;monomer;Mus;neoantigens;Nucleic Acids;Pathway interactions;peptide based vaccine;Peptide Vaccines;Peptides;polymerization;Polymers;Preclinical Testing;Predisposition;prevent;Prodrugs;prophylactic;Proteins;Recombinant Cytokines;Rejuvenation;Research;research clinical testing;resiquimod;Risk;Safety;Structure;subcutaneous;success;synergism;System;systemic toxicity;T cell response;T-Cell Activation;T-Lymphocyte Epitopes;Technology;Testing;Therapeutic;Time;Tissues;Toxic effect;trafficking;Transgenic Mice;Translations;tumor;Tumor Antigens;tumor growth;Vaccination;vaccine access;Vaccine Adjuvant;vaccine delivery;vaccine development;vaccine efficacy;vaccine formulation;Vaccines

PROJECT_TITLE: An integrated polymeric carrier for subunit cancer vaccines

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Stunted growth and development are leading risk factors in the global burden of disease, and if trends continue, the global community will fail to meet 2025 stunting targets established by the World Health Assembly by 27 million children. The Grandi Byen research offers not only the promise of insights into complex biological and psychosocial mechanisms, but feasible solutions to confront stunted growth and development. The intervention taps available resources with high impact potential – willing parents vested in their child’s development, affordable animal source foods for high quality nutrition, and WASH behaviors to mitigate urban infection risks. !

PI_NAMEs: IANNOTTI, LORA LYNN;KOHL, PATRICIA LYNN (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: 5 year old;acceptability and feasibility;Affect;Age Months;Animal Sources;Area;arm;Behavior;Behavioral;Biological;Biological Factors;Biological Markers;Biological Sciences;bone age;bone health;Brain;burden of illness;Cessation of life;Child;Child Behavior;Child Development;Child Nutrition;Child Rearing;Child Support;Childhood;Cognition;Cognitive;Communities;Complementary Feeding;Complex;Data;Development;diarrheal disease;Diet;Dietary Intervention;Disease;disorder risk;economic evaluation;Economic Factors;Economics;Ecuador;Effectiveness;egg;Emotional;Enrollment;Enteral;evidence base;experience;Face;Food;Growth;Growth and Development function;Haiti;Haitian;Height;Hygiene;Impairment;Infant;Infant Care;infection risk;insight;Intervention;Language;Language Development;Length;life span;Mediating;Methods;Mothers;Motor;multi-component intervention;National Institute of Child Health and Human Development;Nutrient;nutrition;Outcome;Parents;Pathway interactions;pediatric trauma;Personal Satisfaction;Pilot Projects;pilot test;Population;Poverty;primary outcome;psychoeducation;psychosocial;Randomized, Controlled Trials;Reproducibility;Research;Research Infrastructure;Resources;Risk Factors;Sanitation;Site;social;social factors;Social Sciences;standard care;Supplementation;Testing;traumatic stress;trend;Urban Community;Water;Work;World Health

PROJECT_TITLE: Supporting child growth and development through integrated, responsive parenting, nutrition and hygiene


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic short sleep is increasingly common in the United States and is a risk factor for the most common tauopathy, Alzheimer disease. We recently discovered that chronic short sleep hastens the temporal progression of tauopathy. The proposed studies will identify mechanisms underlying the sleep loss- induced progression of tauopathy and thereby reveal therapeutic targets to prevent sleep loss worsening of tauopathies, including Alzheimer disease.

PI_NAMEs: NAIDOO, NIRMALA NIRINJINI;VEASEY, SIGRID C (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Abbreviations;activating transcription factor;Acute;Alzheimer's Disease;Back;Behavioral;Biochemical;Brain region;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calmodulin;Calpain;CCAAT-Enhancer-Binding Proteins;Chronic;Developed Countries;effectiveness testing;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Feeds;Gliosis;GRP78 gene;Hippocampus;Human;Impairment;in vivo;in vivo calcium imaging;Injury;Inositol;knock-down;Mediating;Microinjections;Modeling;Modification;Molecular;Molecular Chaperones;mouse model;Mus;nerve injury;neurobehavioral;neuron loss;Neurons;older adult;Pathologic;Peptide Initiation Factors;pharmacologic;Phosphotransferases;Play;Predisposition;prevent;PRKR gene;protein kinase R;response;Rest;Risk Factors;Role;Sleep;Sleep Deprivation;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic target;Transgenic Mice;Transgenic Organisms;United States;Viral Vector;Wakefulness

PROJECT_TITLE: Cellular and Molecular Basis of Sleep Loss Neural Injury in Alzheimer Disease

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Tourette Syndrome

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The proposed project aims to test a new neurofeedback intervention for adolescents with Tourette Syndrome that trains them to control activity in a region of their brain believed to be involved in tic generation. The clinical efficacy of the intervention will be evaluated. We will also monitor how the intervention affects brain patterns to confirm that it is working in the expected manner and to explore its effects on brain networks.

PI_NAMEs: HAMPSON, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Adolescent;Adopted;Affect;Affective;Age;Area;association cortex;Attention;Basic Science;Behavior Therapy;Behavioral;Biological Psychiatry;Brain;Child;Chronic;Clinical;clinical application;clinical effect;clinical efficacy;Clinical Trials;Cognitive;cognitive task;Complex;Control Groups;Corpus striatum structure;Crossover Design;Cues;Data;design;Disease;Double-Blind Method;Down-Regulation;Electric Stimulation;Ensure;Evidence based treatment;experimental group;Feedback;follow-up;Forms Controls;frontier;Functional disorder;Functional Magnetic Resonance Imaging;Generations;Gilles de la Tourette syndrome;improved;interest;Intervention;intervention effect;Involuntary Movements;Learning;Manuals;Measures;mental imagery;Monitor;Morphologic artifacts;Motivation;Motor;Motor Activity;Movement;neural;neural circuit;Neurodevelopmental Disorder;neurofeedback;Participant;Patients;Pattern;Performance;Pharmaceutical Preparations;phenomenological models;Psyche structure;Publishing;Randomized;Relaxation;Reporting;Research Design;Rest;Running;Sensory;Severities;Signal Transduction;stress reduction;Structure;symptomatic improvement;Symptoms;Techniques;Testing;Time;Training;Treatment Efficacy;Up-Regulation;Visual

PROJECT_TITLE: Neurofeedback from the supplementary motor area for Tourette Syndrome


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The current opioid crisis highlights the major threat to public health posed by addictions, including those to nicotine, drugs, and alcohol. Research is needed to translate new basic and clinical advances into effective, sustainable, and accessible treatment in our communities. The NIDA Clinical Trials Network and the New York Node seek to fill this gap by using science to engage researchers, healthcare providers from primary care to specialty care, and policy makers in research to improve addiction treatments nationally.

PI_NAMEs: MCNEELY, JENNIFER  (contact);NUNES, EDWARD V.

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Academia;Academic Medical Centers;Accident and Emergency department;addiction;Address;Adoption;Advocacy;Alaska Native;Alcohols;American Indians;Ancillary Study;Area;Attention;Behavior Therapy;Buprenorphine;Caring;Cities;Clinic;Clinical;clinical care;Clinical Management;clinical research site;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Communities;community organizations;cost effective;Criminal Justice;Data;Data Analytics;Data Science;digital;digital intervention;digital treatment;Effectiveness;Electronic Health Record;Evidence based intervention;Funding;Future;Generations;Goals;Health;health care settings;health data;health economics;Health Personnel;Health system;Healthcare Systems;Helping to End Addiction Long-term;implementation facilitation;implementation science;improved;Individual;Infrastructure;Injections;innovation;interest;International;Intervention;Lead;Leadership;Long Island;Longterm Follow-up;Mainstreaming;Medical;medical specialties;Mental disorders;Mental Health;Mentors;Mentorship;metropolitan;Minority;Mission;Naltrexone;National Institute of Drug Abuse;New York;next generation;Nicotine;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;Patients;performance site;Pharmaceutical Preparations;Pharmacotherapy;Policies;Policy Maker;pre-exposure prophylaxis;precision medicine;predictive modeling;Prevention;Prevention trial;Primary Care;primary care provider;Provider;Public Health;Recording of previous events;Registries;Research;Research Personnel;Research Training;rural area;Schedule;Science;Scientist;Services;stimulant dependence;Structure;Surveys;technology intervention;telehealth;therapy development;Training;Training Programs;Translating;translational pipeline;Treatment outcome;treatment program;treatment research;treatment trial;United States National Institutes of Health;Update;virtual;Vision;Withdrawal;Woman;Work

PROJECT_TITLE: NIDA Clinical Trials Network: New York Node


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: FARMINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Traumatic brain injury remains a significant public health issue with diffuse axonal injury (DAI) as a primary contributor to patient morbidity, especially in pediatric populations. I will test the hypotheses that unmyelinated axon segments serve as initiating loci for DAI pathogenesis with the cytoskeletal protein spectrin contributing to secondary (delayed) axotomy and that neuroprotective strategies to preserve cytoskeletal integrity will improve outcomes. Integration of histology, behavioral studies, and advanced neuroimaging techniques will provide novel insights into DAI pathobiology and create a model that predicts injury severity and prognosticates post- traumatic recovery.

PI_NAMEs: KELLEY, BRIAN J. (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Advisory Committees;Affect;Algorithms;Antibodies;Axon;axon injury;Axotomy;behavioral outcome;behavioral study;Biomechanics;Calpain;calpastatin;career;Childhood;Clinical;Collaborations;Communities;Cytoskeletal Proteins;Cytoskeleton;Deformity;demographics;design;Development;Diffuse;Diffuse Axonal Injury;Diffuse Brain Injury;Doctor of Philosophy;effective therapy;effectiveness evaluation;Ensure;Environment;Event;Experimental Models;Fellowship;fluid percussion injury;Future;Genomics;Histologic;Histology;improved;improved outcome;Injury;insight;instructor;Knock-out;Knockout Mice;Mediating;Mentors;Methods;Microtubules;Mind;Molecular;Morbidity - disease rate;mouse model;Myelin;Nature;Nervous System Trauma;Neurobiology;neurofilament;neuroimaging;neuroinflammation;neuron loss;neuronal cell body;Neuronal Plasticity;Neurons;neuroprotection;neurosurgery;Nodal;novel;Outcome;overexpression;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Patients;Pennsylvania;Peptide Hydrolases;Physicians;Population;Positioning Attribute;predictive modeling;preservation;prevent;professor;prognostication;Program Development;Protein Biochemistry;Protein Subunits;Public Health;Ranvier's Nodes;Recovery;Rehabilitation therapy;Research;Research Personnel;Research Proposals;Residencies;Resources;response;Role;Scientist;Secondary to;Severities;Shapes;Site;Spectrin;Spinal;Structural Protein;success;Techniques;Testing;theories;Therapeutic;therapy design;Training Programs;Trauma;Traumatic Brain Injury;treatment strategy;Universities

PROJECT_TITLE: Molecular Mechanisms and Treatment of Diffuse Axonal Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Innate sensing of pathogens by dendritic cells (DCs) and subsequent DC-mediated priming of immune responses is critical to successful control of infections, yet may be subverted in autoimmune diseases and cancer. The proposed studies would provide novel molecular insights into the control of DC functions, facilitating future therapeutic approaches to above-mentioned diseases.

PI_NAMEs: REIZIS, BORIS  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Antigen Presentation;Architecture;ATAC-seq;Autoimmune Diseases;Binding;Binding Sites;Cell Differentiation process;Cell Physiology;cell type;Cells;Cellular biology;Chromatin;Chromatin Loop;Chromatin Modeling;chromosome conformation capture;Chromosome Structures;cohesin;Cross Presentation;CSPG6 gene;cytokine;Data;Dendritic Cells;Development;Disease;Enhancers;Epigenetic Process;Future;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Hi-C;Immune;Immune response;Impairment;In Vitro;in vitro Model;in vivo;Infection Control;insight;Interferon alpha;Interferon Type I;Interferons;Interleukin-12;Malignant Neoplasms;mammalian genome;Mediating;Mediator;migration;Modeling;Molecular;novel;Nucleic Acids;pathogen;Production;programs;promoter;protein complex;recruit;Regulation;response;Role;Sentinel;Site;Specific qualifier value;stem cells;Stimulus;T cell response;T-Lymphocyte;TCF7L2 gene;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing

PROJECT_TITLE: Chromatin architecture as a regulator of dendritic cell function


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Rare Diseases;Tuberculosis

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE In non-pandemic periods, tuberculosis (TB) is the leading killer from a curable infectious disease, while malnutrition, both undernutrition and poor nutrition leading to conditions such as diabetes mellitus, is the most important driver of TB disease globally. This Global Infectious Diseases Research Training Program (GIDRTP) aims to strengthen existing educational and research linkages with the University of Virginia and the Kilimanjaro Christian Medical University College/ Kilimanjaro Clinical Research Institute in Tanzania, to develop postdoctoral research leaders working in malnutrition and TB. Utilizing lessons learned from prior GIDRTPs at University of Virginia and harnessing the current infrastructure of funding from the National Institutes of Health, Bill and Melinda Gates Foundation, European and Developing Countries Trials Partnership, World Health Organization and the Danish Ministry of Foreign Affairs for TB and malnutrition research in Tanzania, we aim to support postdoctoral trainees' growth to junior scientists and content leaders that will compete for independent funding, set research agendas, make policy and benefit their communities in-line with the World Health Organization's End TB Strategy.

PI_NAMEs: HEYSELL, SCOTT K (contact);MPAGAMA, STELLAH GEORGE

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Africa;career;Caring;Categories;Cessation of life;Clinical Research;college;Communicable Diseases;Communication;Communities;COVID-19;design;Developing Countries;Diabetes Mellitus;Disease;doctoral student;Education;Emerging Communicable Diseases;European;experience;Faculty;Foundations;Funding;global health;Grant;Growth;Health;health equity;Infectious Diseases Research;Infrastructure;International;Lead;Leadership;Malnutrition;Medical;Mentors;minority health;Needs Assessment;nutrition;Policy Making;post-doctoral training;Postdoctoral Fellow;Poverty;Public Health;Reporting;Research;Research Institute;Research Training;Scientist;skills;Structure;Tanzania;Testing;Training;Training Programs;Tuberculosis;undergraduate student;United States National Institutes of Health;Universities;Virginia;World Health Organization;Writing

PROJECT_TITLE: Developing research leaders at the intersection of malnutrition and tuberculosis in Tanzania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Z(55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative Pigments produced by bacterial pathogens contribute to the virulence of the microorganism. Here we describe the discovery of and propose to elucidate the composition of an uncharacterized pigment of the human pathogen Streptococcus pyogenes (Group A Streptococcus). It is also our objective to identify genes involved in its biosynthesis and regulation, and how the pigment aids in bacterial fitness or pathogenesis. Our proposed work is likely to advance the understanding of how S. pyogenes survives in the body and may advance efforts to develop a successful vaccine against this pathogen.

PI_NAMEs: FEDERLE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acetyltransferase;Acute;Air;Anabolism;Antibiotic Therapy;antimicrobial;Bacteria;bacterial fitness;Carotenoids;Cell Density;cell killing;Cells;Chemicals;Chromatography;Circulation;Clinical;Color;cytotoxic;dehydrogenation;environmental stressor;Enzymes;Event;Exposure to;Exudate;fitness;Gene Family;Genes;Genetic Screening;glycosylation;glycosyltransferase;Growth;Hand;Human;human pathogen;Hyperpigmentation;Immune;Infection;Inflammatory;Laboratories;Ligase;Lipids;Literature;Macrophage;Methods;microorganism;Mutagenesis;mutant;Nasopharynx;Neutrophil Infiltration;new therapeutic target;Nuclear Magnetic Resonance;Operon;Oranges;Organism;Oxidative Stress;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pharyngeal structure;Phenotype;Pigments;Polyenes;Production;Property;Pseudomonas aeruginosa;Reactive Oxygen Species;Recurrence;Regulation;Respiratory Burst;Serotyping;Skin;Skin colonization;Staphylococcus aureus;Streptococcus Group B;Streptococcus pyogenes;Stress;stressor;Structure;Testing;Tonsil;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Discovery of a pigment produced by Streptococcus pyogenes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-D(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Brain tissues or plasma samples from patients and mice with Alzheimer’s disease (AD) contain increased levels of mast cells (MCs), MC activator IgE, IgE receptor FcεR1, and MC activation products. Our preliminary studies demonstrated that MC-deficiency or inhibition with an over-the-counter human anti-allergy drug Zaditor® improved AD-like pathologies and memory loss in mice. This proposal will test the hypothesis that MCs play a direct role in AD pathogenesis and the human anti-allergy drugs may have therapeutic potential in AD patients.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta deposition;activation product;Adoptive Transfer;Affect;allergic response;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;Anti-Allergic Agents;anti-IgE;Antibodies;antibody detection;Antibody Therapy;Astrocytes;Behavior;behavior test;Binding;Bispecific Antibodies;Blood - brain barrier anatomy;blood-brain barrier permeabilization;brain endothelial cell;brain tissue;Cause of Death;Cd68;Cell surface;Cells;cerebral amyloidosis;Cerebral cortex;chemokine;Chymase;Clinical;Cognitive;cytokine;Data;Dementia;Deposition;disability;Disease;Disease Progression;Dose;drug withdrawal;Elderly;Endothelial Cells;Engineering;Enzyme-Linked Immunosorbent Assay;Event;extracellular;Extravasation;Fc Receptor;Genetic;Goals;Hippocampus;Histamine;Human;Hypersensitivity;IgE;IgE Receptors;IL6 gene;Imaging Techniques;Impaired cognition;improved;In Vitro;Infiltration;Inflammatory;inhibitor;Interferon Type II;Link;mass spectrometric imaging;mast cell;Memory Loss;Metabolism;Microglia;Mus;neuron loss;Neurons;neurotoxic;Non-Prescription Drugs;novel therapeutics;omalizumab;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;Phagocytes;pharmacologic;Plasma;Play;prevent;Production;Proto-Oncogene Protein c-kit;reconstitution;Role;Sampling;Senile Plaques;Site;Source;Stains;Synapses;T-Lymphocyte;Techniques;Technology;Testing;TFRC gene;Thalamic structure;Therapeutic;therapeutic evaluation;Tissue Extracts;TNF gene;Treatment Efficacy;Tryptase;Water;Xolair

PROJECT_TITLE: Role of Mast cells in Alzheimer's Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Activity;Prevention;Rehabilitation;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: Chronic pain is a prevalent and difficult-to-treat problem for at least half of all persons receiving opioid agonist therapy (OAT) for opioid use disorder – i.e., buprenorphine/ naloxone (BUP) or methadone maintenance treatment (MMT). Hatha yoga may be a useful and attractive adjunctive treatment for pain in OAT patients that could serve to decrease suffering related to pain as well as decrease risk of relapse and improve quality of life.. In this project, we propose to study various potential intervention components, with the goal of create an optimized yoga intervention package that can be tested in the next step in this line of research, which is fully- powered efficacy trial with the primary outcome of reduced life interference due to pain.

PI_NAMEs: STEIN, MICHAEL D;UEBELACKER, LISA A (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Behavior Therapy;Behavioral;Benchmarking;chronic pain;chronic pain management;Clinic;Clinical Trials;craving;Data;Decision Making;design;disability;dosage;Dose;efficacy evaluation;efficacy trial;Enrollment;Evaluation;experimental study;financial incentive;follow up assessment;Funding;Future;Goals;Health behavior change;Health education;Home;Human;Illicit Drugs;improved;indexing;instructor;Intervention;intrinsic motivation;Life;Literature;Maintenance;Manuals;Measures;meetings;Mental disorders;methadone treatment;mindfulness intervention;Modeling;multiphase optimization strategy;National Center for Complementary and Integrative Health;NIH Program Announcements;Opioid;opioid agonist therapy;opioid misuse;opioid use disorder;Outcome;Pain;Pain interference;Pain management;pain reduction;pain-related disability;Participant;Patient Recruitments;Patients;Persons;Pharmacological Treatment;Phase;pilot trial;Population;Preparation;prevent;primary outcome;Procedures;Quality of life;Randomized;recruit;Relapse;relapse risk;Reporting;Research;Research Design;Research Personnel;Risk Factors;Running;Schedule;Serious Adverse Event;Severities;Site;Suboxone;substance misuse;substance use;teacher;Testing;Text Messaging;Theory of Change;Time;Training;treatment adherence;Work;Yoga

PROJECT_TITLE: Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Relevance to Public Health (2-3 sentences): Annually, approximately 1 in 12,500 Americans are newly diagnosed with acute myeloid leukemia (AML) and over 12,000 die from the disease. The overall survival rate of AML patients is below 25% for adults and 70% for children and these poor outcomes are largely due to high rates of resistance to the current standard of care treatments and disease relapse. The aim of this proposal is to identify the molecular underpinnings of AML pathogenesis and therapy resistance to develop more effective therapeutic strategies.

PI_NAMEs: SYKES, STEPHEN MATTHEW (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: activating transcription factor 3;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult;Affect;American;Biochemical Pathway;Carbon;Catabolism;Cell Cycle;Cell Differentiation process;cell growth;Cell Physiology;Cell Proliferation;Cells;Chemicals;chemotherapy;Child;Data;dietary;dietary restriction;Differentiation and Growth;Disease;Disease Progression;DNA biosynthesis;effective therapy;Effectiveness;Enzymes;experimental study;FLT3 gene;Foundations;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genetically Engineered Mouse;Goals;Hematopoiesis;Hematopoietic Neoplasms;Human;improved;In Vitro;in vivo;inhibitor;insight;Karyotype;leukemia;leukemogenesis;Liposomes;LoxP-flanked allele;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;nanoparticle;Newly Diagnosed;Non-Essential Amino Acid;novel therapeutic intervention;Onset of illness;Outcome;overexpression;Pathogenesis;patient derived xenograft model;Patients;pharmacologic;Play;Positioning Attribute;posttranscriptional;programs;Proliferating;protein expression;Proteins;Proteomics;Public Health;Purines;Recurrent disease;Reporting;Resistance;RNA;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serine;Shunt Device;small hairpin RNA;standard of care;Supplementation;Supporting Cell;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Tissues;transcription factor;transcriptome sequencing;transcriptomics;treatment strategy;tumor;Work

PROJECT_TITLE: Determining the Role and Targeting potential of Serine Metabolism in aggressive sub-types of Acute Myeloid Leukemia

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Precision Medicine;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: Project Narrative Annual lung cancer screening and tobacco treatment are pillars of cancer prevention and control yet are often not provided by physicians or received by patients in primary care settings. New evidence suggests that personalized risk feedback including a patient's genetic and clinical information could highlight the benefits of these practices and engage physicians and patients in improved care. This study will test the impact of a genetically-informed intervention on physicians' ordering and patients' completion of lung cancer screening and tobacco treatment in primary care.

PI_NAMEs: CHEN, LI-SHIUN ;RAMSEY, ALEX TAYLOR (contact)

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: Accounting;Address;Adult;African American;African American population;aged;arm;Behavior;behavior change;Behavioral Mechanisms;cancer care;Cancer Control;cancer prevention;cancer risk;Caring;Cause of Death;cigarette smoking;Clinical;Cognitive;Communication Tools;Consensus;Continuity of Patient Care;Data;design;efficacious treatment;Eligibility Determination;Environment;evidence base;Feedback;former smoker;Genetic;genetic information;Genetic Risk;genome-wide;Genomics;Goals;Guidelines;health disparity populations;improved;Incidence;individualized prevention;innovation;Institution;Intervention;low dose computed tomography;lung basal segment;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;medically underserved;Meta-Analysis;mortality;motivated behavior;multidisciplinary;Nature;novel;Outcome;patient oriented;Patients;Perception;Pharmacotherapy;Physicians;Population;preventable death;Prevention strategy;Primary Care;Primary Care Physician;primary care setting;primary outcome;Randomized;Randomized, Controlled Trials;Recommendation;Research;Risk;Risk Reduction Behavior;screening;Screening for cancer;secondary outcome;Signal Transduction;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Smoking History;social;Source;Strategic Planning;success;support tools;Testing;theories;therapy development;Tobacco;tool;treatment as usual;Underserved Population;uptake;Work

PROJECT_TITLE: Precision prevention strategy to increase uptake and engagement in lung cancer screening and smoking cessation treatment

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Aging;Biotechnology;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Respiratory syncytial virus (RSV) is a significant pathogen for elderly populations, but despite decades of effort, no vaccine exists to protect this or any population from RSV infections. This project will develop a novel RSV vaccine candidate for the elderly using cotton rats as a surrogate human model. The results of the study will provide new information about elderly immune responses to RSV and vaccines and key data to support planning for clinical trials of the vaccine safety and efficacy in the elderly.

PI_NAMEs: MORRISON, TRUDY G. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Adjuvant;Adult;Affinity;Age;Aging;Animal Model;Animals;Antibodies;Antibody titer measurement;Avidity;Birds;Bone Marrow;Cessation of life;Clinical Trials;Core Protein;Cotton Rats;Data;design;Developed Countries;Development;Dose;Elderly;experience;experimental study;Failure;Goals;GTP-Binding Proteins;Hospitalization;Human;human model;Immune response;Immunization;Immunize;Immunologics;immunosenescence;Influenza;influenzavirus;Memory;Memory B-Lymphocyte;memory recall;Modeling;Mus;neutralizing antibody;Newcastle disease virus;novel;novel vaccines;novel virus;offspring;pathogen;Plasma Cells;Population;population health;Preparation;Proteins;Protocols documentation;prototype;Public Health;Reporting;Reproducibility;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory syncytial virus RSV F proteins;Respiratory Syncytial Virus Vaccines;response;Route;Serum;Testing;vaccination protocol;vaccine candidate;Vaccine Clinical Trial;vaccine efficacy;vaccine safety;Vaccines;Viral Proteins;Virus-like particle

PROJECT_TITLE: Development of an RSV vaccine for the elderly

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Diverse cancers can now be treated by modulating the immune system to recognize and destroy tumor cells. However, only subsets of patients respond to such immunotherapies and tumors often progress despite these efforts. Here, we use a new method to grow tumors alongside invading immune cells as 3-dimensional “patient- derived organoids” (PDOs) to understand and improve cancer immunotherapy.

PI_NAMEs: KUO, CALVIN J (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adoptive Cell Transfers;Adoptive Transfer;Aftercare;Air;air treatment;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1;anti-PD1 therapy;anti-tumor immune response;Antigens;Autologous;B-Lymphocytes;Biopsy;Bioreactors;cancer immunotherapy;cell killing;Cells;Cellular immunotherapy;checkpoint inhibition;chimeric antigen receptor T cells;Clinical;clinical decision-making;clinical efficacy;Coculture Techniques;cohort;Complex;cytotoxicity;Data;Detection;Development;Epithelium;Equilibrium;exhaust;Exhibits;follow-up;Human;human model;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunologic Surveillance;Immunological Models;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro activity;in vitro Model;in vivo;inhibitor therapy;Interleukin-2;Invaded;Ligands;Liquid substance;Macrophage;Malignant Neoplasms;Melanoma;Melanoma Tumor;Methods;Modeling;mouse model;Mus;Natural Killer Cells;Nature;neoplastic cell;network models;next generation;Nodal;novel;Organoids;Outcome;patient response;patient subsets;Patients;Peptides;peripheral blood;Phosphoric Monoester Hydrolases;Population;predictive marker;preservation;Primary Neoplasm;programmed cell death ligand 1;programmed cell death protein 1;Progressive Disease;prospective;Protein Dephosphorylation;receptor;Receptor Inhibition;reconstitution;recruit;Resistance;Resolution;response;restraint;Sampling;single-cell RNA sequencing;skin biopsy;Skin Malignancy;skin squamous cell carcinoma;success;System;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Therapeutic antibodies;Time;TNFRSF5 gene;treatment trial;trial comparing;tumor;Tumor Antigens;Tumor Cell Line;Tumor Escape;tumor immunology;tumor progression;tumor specificity;Tumor-Derived;Tumor-Infiltrating Lymphocytes;tumorigenesis

PROJECT_TITLE: Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Narrative In mice, evidence suggests that allergic disease may protect from death due to a respiratory viral infection. Using mouse and human approaches, this proposal will identify mechanistic pathways that provide protection, with the ultimate goal of developing a therapeutic to prevent death from respiratory viral infections.

PI_NAMEs: GRAYSON, MITCHELL H (contact)

PROJECT_TERMS: 2019-nCoV;5 year old;Adoptive Transfer;Air;airway epithelium;airway hyperresponsiveness;Allergic Disease;Antibodies;Asthma;atopy;Caring;CD14 gene;Cell Culture Techniques;Cell Physiology;Cells;Cellular Infiltrate;Cessation of life;Child;Cytoprotection;Data;Death Rate;Dendritic Cells;Development;Disease;Dose;Elderly;eosinophil;Epithelial Cells;experimental study;Future;gene product;Genetic Transcription;Goals;Green Fluorescent Proteins;Hematopoietic;Homeostasis;Hospitalization;Hospitalized Child;Human;human data;human old age (65+);IL4 gene;Impairment;In Vitro;in vivo;infancy;Infant;Infection;Inflammatory;Influenza;Interferons;Interleukin-13;ITGAX gene;Liquid substance;Lung;Macrophage Activation;Mediating;Medical;Metabolic;Metaplasia;Mitochondria;Modeling;Monoclonal Antibodies;monocyte;mortality;mouse model;Mucous body substance;Mus;Neuregulin 1;novel strategies;Outpatients;Para-Influenza Virus Type 1;parainfluenza virus;pathogenic virus;Pathway interactions;peripheral blood;prevent;Process;Production;protective effect;Publications;Pyroglyphidae;receptor;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Role;SARS-CoV-2 infection;Sendai virus;Severities;single-cell RNA sequencing;Sorting;Stress;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Therapeutic Studies;Tight Junctions;Translating;TSLP gene;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;Visit

PROJECT_TITLE: Pre-Existing Atopy and Respiratory Viral Infections

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PHR: Relevance Whereas most technology development related to T cells derives from study of peptide antigens, human T cells broadly respond to mycobacterial lipids that are displayed on the surface of CD1 proteins. Further, recent studies show that CD1-reactive T cell responses occur broadly in humans and use T cell receptors that are similar among patients. Here we propose to determine the mechanisms of lipid recognition by T cells during tuberculosis infection to identify lipids that can be used for diagnosis and treatment needed to contain the worldwide TB epidemic, which killed more than one million people last year.

PI_NAMEs: MOODY, DAVID BRANCH (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Animal Model;antigen binding;Antigen Presentation;Antigens;autoreactive T cell;Bacterial Antigens;Binding;Biological Assay;Carbohydrates;Cavia;cell type;Clone Cells;cohort;cytokine;Data;Diagnosis;Disease;Epidemic;Epitopes;Gene Expression Profiling;Genes;genome-wide;Genotype;glucose mycolate;Glycolipids;Goals;Host Defense;Human;human disease;Human Genome;Immune system;Immunodiagnostics;Immunogenetics;Immunologics;Immunotherapy;In Vitro;Inbreeding;Individual;Infection;innovation;inorganic phosphate;Left;Lipids;Lung;Major Histocompatibility Complex;Maps;Measures;Membrane;Methods;Modeling;Monoclonal Antibodies;Mutation;mycobacterial;Mycobacterium tuberculosis;Nature;New Guinea;pathogen;Patients;Pattern;Peptides;Persons;Phospholipids;Population;protein complex;Proteins;Publications;Publishing;Reagent;Receptor Activation;receptor binding;Research;response;Role;Side;Structure;Study models;success;Surface;System;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;TCR Activation;technology development;Testing;Time;tool;Translating;Tuberculosis;tuberculosis treatment;Vaccines;Work

PROJECT_TITLE: T cell responses to CD1-restricted lipids in tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(90)S]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Complementary and Integrative Health;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Genetics;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE We have found that maternal folic acid supplementation via intraperitoneal injection rescues cleft palate phenotype in a mouse model. The proposed studies will elucidate the minimum dose and embryonic developmental window for folic acid treatment, as well as the cellular and molecular mechanism of the rescue. Our long-term goal is to build upon these findings and identify therapeutic strategies for early intervention to reduce the incidence of cleft palate.

PI_NAMEs: SAADI, IRFAN  (contact);TRAN, PAMELA VIVIAN

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Actins;Actomyosin;Affect;Alleles;Binding;Birth;cell growth regulation;Cell Proliferation;Cells;cleft lip and palate;Cleft Palate;Coiled-Coil Domain;Complex;Congenital Abnormality;Craniofacial Abnormalities;Cytoskeleton;Data;Defect;Development;dietary;dosage;Dose;Early Intervention;Embryo;Environment;Environmental Risk Factor;Etiology;experimental study;F-Actin;Female;Folic Acid;folic acid supplementation;Future;Genetic;Goals;Growth;Hour;Human;improved;in utero;Incidence;innovation;insight;Intake;Intervention;Intervention Studies;intraperitoneal;Intraperitoneal Injections;Knock-in;Knowledge;Mediating;Mesenchyme;Methodology;Methods;Microtubules;Modeling;Molecular;Molecular Target;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myosin Type II;Neural Tube Closure;Neural Tube Defects;non-muscle myosin;novel;orofacial cleft;palatal shelves;Palate;palatogenesis;Patients;Phenotype;phosphoproteomics;pregnant;prevent;Process;Proteomics;Scaffolding Protein;Smoking;Source;Specific qualifier value;Stains;Syndrome;System;Therapeutic;Three-dimensional analysis;Time;Tissues;translational potential

PROJECT_TITLE: In utero rescue of cleft palate using maternal administration of folic acid


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: This research is of high public health relevance because of the sizable population of adolescents with epilepsy at high risk for lifelong impairments in executive functioning (i.e., skills necessary for goal-directed and complex activities, including problem-solving, initiating, monitoring, organization, planning, self-regulation and working memory) and quality of life. We will test Epilepsy Journey, a multicomponent treatment program with web- based modules and telehealth visits, which is designed to equip adolescents (ages 13-17) with epilepsy with problem-solving skills to manage their executive function challenges. This work is relevant to the NIND’s mission to help all people live longer, healthier lives and will ultimately reduce health disparities and improve access to psychosocial care.

PI_NAMEs: MODI, AVANI C (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Address;Adolescent;Adult;adverse outcome;Affect;Aftercare;Age;arm;Attention deficit hyperactivity disorder;Behavior;Behavioral;behavioral health;behavioral health intervention;Behavioral Symptoms;Childhood;childhood epilepsy;Client satisfaction;Clinical;Cognition;Combined Modality Therapy;comorbidity;Complex;depressive symptoms;design;efficacy evaluation;eHealth;Epilepsy;Evaluation;Evidence based intervention;Executive Dysfunction;executive function;Focus Groups;Goals;high risk;high risk population;high-risk adolescents;Impairment;Improve Access;improved;indexing;Individual;Informal Social Control;informant;innovation;Intervention;Learning;Learning Module;Long-Term Effects;Maintenance;Measures;Mental Depression;Methods;Mission;Monitor;neglect;neurobehavioral;Neurologic;Online Systems;Outcome;Parents;Participant;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;pilot trial;Play;Population;Prevalence;prevent;Problem Solving;Process;Psychosocial Assessment and Care;public health relevance;Quality of life;racial diversity;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Reduce health disparities;Reporting;Research;Risk;Role;Sampling;Seizures;Short-Term Memory;side effect;Site;skills;social;social relationships;Statistical Data Interpretation;success;teacher;Teenagers;telehealth;Testing;treatment as usual;treatment comparison;treatment program;United States;United States National Institutes of Health;Visit;Vulnerable Populations;Work;Youth

PROJECT_TITLE: A Phase 3 clinical trial of an e-health behavioral intervention to improve executive functioning in adolescents with epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-G (62)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunization;Immunotherapy;Women's Health Research

ORG_CITY: ALBANY

ORG_NAME: ALBANY COLLEGE OF PHARMACY

PHR: We are proposing to create new miniaturized sampling devices that are specifically designed for measurement of drugs at their site of action. The proposed microextraction-based techniques will be used to analyze antibody drugs in the body (and tumors), alleviating the need for blood draws and biopsies. This research will expand our understanding of medicinal drugs and will facilitate the correct determination of therapeutic drug doses – ultimately increasing the safety of medication for all age groups.

PI_NAMEs: MUSTEATA, FLORIN MARCEL (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Accident and Emergency department;Adverse effects;Affinity;age group;Aliquot;analytical tool;Animal Experiments;Animal Model;Animals;Antibodies;Apoptosis;Binding;biocompatible polymer;Biological Markers;Biology;biomaterial compatibility;Biopsy;Blood;Blood specimen;Body Fluids;Buffers;C57BL/6 Mouse;Calibration;cancer cell;Cardiac;Cause of Death;Cell Culture Techniques;Chromatography;Clinical;cost;Data;design;detection limit;Development;Devices;Diffusion;Disease;Dose;drug development;drug distribution;Drug Kinetics;Drug Monitoring;Drug Targeting;Electrolytes;Ethical Issues;evaporation;Extracellular Fluid;Fc Receptor;flexibility;Fluid Balance;Freedom;Harvest;Health;Health Personnel;Healthcare;Human;Hydrophobicity;Immune checkpoint inhibitor;Immune response;Implant;improved;In Vitro;in vivo;in vivo evaluation;innovation;Intercellular Fluid;interest;Investigation;Kinetics;Knock-in;Laboratories;Laboratory Animals;Ligands;liquid biopsy;Liquid substance;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Medical;medication safety;Medicine;Metals;method development;Methodology;Methods;Microdialysis;miniaturize;Modeling;Modernization;Molecular;Monitor;Movement;Mus;Neoplasms;neoplastic cell;novel strategies;novel therapeutics;Organism;Osmosis;Outcome;overexpression;Pathway interactions;Patients;pembrolizumab;Performance;Perfusion;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phase;Plasma;point of care;portability;Power Sources;pre-clinical;precision medicine;predict clinical outcome;preservation;prevent;Procedures;Process;programmed cell death ligand 1;Pump;receptor;receptor binding;Recombinants;Reproducibility;Research;Research Design;Research Personnel;response;Risk;sample collection;Sampling;Site;small molecule;Solid;Specificity;Standardization;Surface;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Therapeutic antibodies;Thinness;Time;Tissue Sample;Tissues;tool;triple-negative invasive breast carcinoma;Tube;tumor;tumorigenesis;Validation;Woman;Work

PROJECT_TITLE: Solid Phase Microextraction as a New Tool for Quantifying Antibody Drugs in Breast Cancer and Building PK-PD models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: KENT

ORG_DEPT: BIOLOGY

ORG_NAME: KENT STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The public health burden of short and long-term hypoxia exposure can be significant, particularly in regions where large populations live at high altitudes. Understanding the genetic basis of acute and chronic hypoxia could lead to the development of new treatments and interventions to improve public health outcomes related to hypoxia exposure. Using birds from the Himalayas that are residing in their “native” altitude and those that will be experimentally exposed to “non-native” altitudes, we will quantify changes in physiological traits and their genomic/transcriptomic signatures, that can directly contribute to the mechanistic understanding of the underlying genetic basis of acute and chronic hypoxia.

PI_NAMEs: LAMICHHANEY, SANGEET  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Acclimatization;Acute;Affect;Altitude;Animal Model;Birds;career;Carrying Capacities;Chronic;clinically relevant;comparative;comparative genomics;coping;Data;Development;differential expression;Disease;drug development;Drug Targeting;effective therapy;Exhibits;experience;experimental study;Exposure to;Financial Support;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic architecture;Genetic Drift;Genetic Variation;Genomic Segment;Genomics;Goals;Health;Hematology;Hemoglobin;Human;Hypoxia;Hypoxia-Inducible Factor Pathway;improved;Individual;innovation;insight;Intervention;Measures;Migrant;Molecular;Mutation;non-Native;Organ;Organism;Outcome;Oxygen;Personal Satisfaction;Phenotype;Physiological;Physiology;Play;Population;Preventive measure;Public Health;Qualifying;Regulation;Regulatory Pathway;Research;Resources;response;Risk Factors;Role;Study models;System;Testing;Time;Tissues;trait;transcriptome;transcriptomics;Transplantation;trend;undergraduate student;Variant;Visit;Work

PROJECT_TITLE: Molecular insights into acute and chronic hypoxia tolerance: Investigating mechanisms of short-term plasticity and long-term genetic adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (80)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative SE-CoAST provides a large, capable, integrated clinical trials network throughout South Carolina, eastern Georgia, and western North Carolina encompassing the “buckle” of the US Stroke Belt. The SE-CoAST network brings research opportunities to communities at highest risk, yet often underrepresented in stroke clinical trials. Successful Stroke Net clinical trials conducted in SE-CoAST will provide insights into the generalizability of successful therapies.

PI_NAMEs: HOLMSTEDT, CHRISTINE ;TURAN, TANYA N (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Academic Medical Centers;Acceleration;Acute;Adult;Black Populations;Black race;care delivery;career;career development;Caring;Childhood stroke;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Conduct Clinical Trials;Cone;Country;Data Collection;Death Rate;Education;Educational Activities;educational atmosphere;Enrollment;Ensure;experience;Funding;Geography;Goals;Health;health care availability;Health Services Accessibility;Healthcare Systems;Heart;high risk;improved;Infrastructure;insight;Interdisciplinary Study;Label;Lead;Leadership;Learning;Medical;Medical center;medical specialties;member;Mentors;Mentorship;Neurologic;next generation;North Carolina;outreach;Participant;Population;Population Heterogeneity;Prevention;prisma;recruit;Rehabilitation therapy;Research;Research Personnel;Research Proposals;response;Role;Rural;Scientist;Services;Site;South Carolina;Stroke;Stroke Belt;stroke clinical trials;stroke education;stroke incidence;stroke risk;stroke trials;StrokeNet trials;success;supportive environment;Teacher Professional Development;tertiary care;Training;translational scientist;United States;Universities

PROJECT_TITLE: Southeast Collaborative Alliance for Stroke Trials (SE-CoAST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;Human Genome;Nutrition;Precision Medicine;Prevention;Women's Health Research

PHR: Project Narrative This Pathway to Independence Award will apply a multi-omics approach, building on the unique design and rich dietary and biomarker data in the Nurses’ Health Studies to comprehensively evaluate the relationship between chronic inflammation and breast cancer risk. The proposed research project will provide novel insight into inflammatory pathways and specific proteins that will serve as the critical first steps for future development of risk biomarkers and therapeutic targets for preventing ER-negative breast cancer. The project also has the potential to inform more effective and precision dietary approaches for the prevention of breast cancer, and particularly aggressive breast tumor subtypes.

PI_NAMEs: ROMANOS-NANCLARES, ANDREA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acylcarnitine;Address;Adherence;advanced analytics;Award;Bioinformatics;Biological;Biological Assay;Biological Markers;biological specimen archives;Blood specimen;Breast Cancer Prevention;Breast Cancer Risk Factor;breast pathology;C-reactive protein;cancer epidemiology;Cancer Etiology;cancer prevention;career;Chemopreventive Agent;Cholesterol Esters;Chronic;Data;Data Sources;design;Development;Diagnostic;Diet;dietary;dietary approach;Dietary Factors;Dietary Practices;Dimensions;Disease;Environment;Epidemiology;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptors;Etiology;experience;Food;Foundations;Functional disorder;Future;Gene Expression;Goals;high dimensionality;high risk;hormone therapy;Hospitals;Immune response;indexing;Inflammation;Inflammatory;innovation;insight;Interleukin-6;Knowledge acquisition;Life Style;lifestyle factors;Longitudinal cohort;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measures;Mentors;metabolome;metabolomics;Methodology;Methods;Multiomic Data;multiple omics;novel;Nurses' Health Study;nutritional epidemiology;Nutritional Study;Obesity;Pathogenicity;Pathology;Pathway interactions;Pattern;Plasma;Play;Positioning Attribute;post-doctoral training;precision nutrition;prevent;Prevention strategy;Prognosis;Proliferating;prospective;Proteins;Proteome;proteomic signature;Proteomics;receptor expression;Research;Research Design;Research Personnel;Research Project Grants;research vision;Resources;Risk;Risk Factors;Role;Sample Size;skills;Solid;Specimen;Strategic Planning;System;Techniques;Technology;Testing;therapeutic target;TNFRSF1A gene;Training;transcriptomics;tumor;Tumor Subtype;Tumor Tissue;United States National Institutes of Health;Up-Regulation;Woman;Work

PROJECT_TITLE: A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: While mutations of LRRK2 are the most common genetic cause of Parkinson's disease (PD), the unmutated form of LRRK2 also seems to play an important role in the neurodegeneration that characterizes typical non-genetic PD. The toxicity of LRRK2 mutations appears to be related to overactivity of this enzyme, and it is unclear how LRRK2 becomes over-activated in non-genetic PD. This project is designed to determine (i) how unmutated LRRK2 gets activated, (ii) where in the cell this occurs and (iii) how this leads to neurotoxicity.

PI_NAMEs: GREENAMYRE, J TIMOTHY (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 4 hydroxynonenal;Accounting;Address;Alanine;Automobile Driving;autosome;Brain Pathology;brain tissue;Cells;Chloroquine;Complex;Consensus;Curcumin;Cysteine;design;dihydroethidium;Disease;Dopamine;dopaminergic neuron;enzyme activity;experimental study;Genetic;Genetic Risk;Human;Hydrogen Peroxide;Idiopathic Parkinson Disease;in vivo;Ionophores;kinase inhibitor;Knock-out;Link;LRRK2 gene;Microglia;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Monovalent Cations;Morphology;mutant;Mutate;Mutation;Nerve Degeneration;Neurons;neurotoxicity;non-genetic;novel;novel therapeutic intervention;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Paraquat;Parkinson Disease;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phosphotransferases;physiologic stressor;Play;prevent;Prevention;Process;Production;Protein Import;Proteins;Rattus;receptor;Regulation;Reporting;Research Personnel;response;Risk Factors;risk variant;Rodent Model;Role;Rotenone;Signal Transduction;Specificity;Stress;stressor;Substantia nigra structure;tool;Toxic effect;toxicant;trafficking;Trichloroethylene;Variant

PROJECT_TITLE: LRRK2 and oxidative stress in Parkinson’s disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hematology;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EL PASO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE Hematopoiesis is the formation of all the cellular components of the blood, and while much is known regarding mechanisms regulating blood cell development, the role of G0/G1 switch gene 2 (G0S2) in normal hematopoiesis remains unknown. Our data suggests that G0S2 is involved in commitment of hematopoietic stem and progenitor cells toward the myeloid lineage. Understanding the role of G0S2 in regulating lipid and energy metabolism during normal hematopoiesis will inform strategies to harness this molecular pathway for treatment of pathologic conditions like metabolic diseases and cancer.

PI_NAMEs: EIRING, ANNA MARIE (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acyltransferase;Adipocytes;Adipose tissue;Admission activity;American diet;Apoptosis;Binding;Blood;Blood Cells;bone cell;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell;career;Cell Cycle;Cell Physiology;Cells;Chronic;cytokine;Data;Defect;design;Development;diet-induced obesity;Disease;Doctor of Philosophy;Ectopic Expression;Education;energy balance;Energy Metabolism;Enzymes;experimental study;fatty acid oxidation;fitness;Flow Cytometry;Future;Goals;graduate student;Granulocyte Colony-Stimulating Factor;Health;Health Sciences;Heart Diseases;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;hematopoietic differentiation;hematopoietic stem cell differentiation;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Hepatocyte;High Fat Diet;Hispanic;Hispanic-serving Institution;Homeostasis;human disease;Hypertension;Immune;in vivo;Individual;Inflammation;Inflammatory;inhibitor;Insulin Resistance;Interleukin-6;Knockout Mice;Knowledge;Laboratories;Lactation;Life;light microscopy;Link;Lipase;lipid metabolism;lipidomics;Lipids;Lipolysis;Liver;Location;lysophosphatidic acid;Macrophage;Malignant Neoplasms;Marrow;Metabolic;Metabolic Diseases;Metabolic syndrome;metabolomics;Mexico;minority children;minority student;Molecular;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;neutrophil;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel therapeutics;Obese Mice;obese person;Obesity;obesity prevention;Occupations;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathway interactions;peripheral blood;Phenotype;Population;Prevalence;Process;Production;programs;Proteins;reconstitution;Red Marrow;Regulation;Research;Research Assistant;response;Risk;Rodent Model;Role;Stains;Students;Switch Genes;Testing;Texas;Thermogenesis;Tissues;TNF gene;training opportunity;Transferase;Triglycerides;United States;Universities;Weight;women versus men

PROJECT_TITLE: G0S2 and lipid metabolism in the regulation of hematopoietic development

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lymphatic Research;Orphan Drug;Precision Medicine;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE The Multicenter International Durability and Safety of Sirolimus in LAM (MIDAS) Registry (NCT02432560) has collected longitudinal data across the United States for about five years on approximately 400 patients with lymphangioleiomyomatosis (LAM), a progressive rare lung disease that occurs primarily in women. The major gaps hindering meaningful progress in LAM include our inability to reliably predict and identify the patients who are at increased risk of disease progression and the lack of a disease-specific patient-reported outcome measure that informs us of items that are most relevant to LAM patients. We seek to empower patients to be at the center of clinical decision making and therapeutic drug discovery in LAM by using the MIDAS data to validate and refine a: 1) risk score calculator that helps predict future risk of lung function decline and response to treatment, and 2) LAM-specific clinical outcome assessment measure that enables the design of patient-centered trials.

PI_NAMEs: GUPTA, NISHANT  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Aftercare;Award;Clinic;Clinical;clinical center;clinical decision-making;clinical outcome assessment;cohort;Consensus;Coughing;Data;Decision Aid;Decision Making;design;Detection;Development;Disease;Disease Progression;disorder risk;drug discovery;Dyspnea;effective therapy;empowerment;Enrollment;European;Evaluation;Fatigue;Female;follow-up;Fostering;FRAP1 gene;Funding;Future;Genes;health assessment;health related quality of life;Health Status;improved;Individual;instrument;inter-individual variation;International;Length;Lung;Lung Diseases;Lung Lymphangioleiomyomatosis;Lymphangioleiomyomatosis;Measurement;Measures;Medicine;Methods;Modeling;Mutation;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;Natural History;Nature;novel;novel therapeutics;optimal treatments;Outcome;Outcome Measure;outcome prediction;Pathway interactions;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;personalized medicine;phase III trial;Physiological;Physiology;prediction algorithm;predictive modeling;predictive tools;primary endpoint;prognostic;prognostication;progression risk;Property;prototype;Publishing;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Quality of life;Quality of Life Assessment;Regimen;Registries;Remission Induction;Reporting;Resources;Respiratory Failure;response;Risk;Safety;Signal Transduction;Sirolimus;Site;Symptoms;System;Testing;Therapeutic;Therapeutic Trials;Time;tool;treatment effect;treatment optimization;treatment response;treatment trial;trend;Tuberous Sclerosis;United States;Validation;Well in self;Woman;Work

PROJECT_TITLE: Patient centered outcome measures and prediction tools in lymphangioleiomyomatosis

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Regenerative Medicine;Rural Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MACON

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: Relevance to Public Health: Mesenchymal Stromal Cell-based cellular therapy is being tested for various inflammatory disorders including Inflammatory Bowel Diseases (IBD). The present study of characterizing novel mesenchymal stromal cells will lead to cellular therapy with enhanced potency and sustained efficacy for the management of IBD complications.

PI_NAMEs: CHINNADURAI, RAGHAVAN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abscess;adipose derived stem cell;Adipose tissue;Adopted;Affect;Allogenic;Anal Fistula;Anatomy;Anus;Area;Autologous;Award;Biological Assay;Biopsy;Bone Marrow;Cell Aging;cell dimension;Cell Therapy;Cells;Characteristics;chemokine;Child health care;Clinical;clinical care;collaboratory;comparative;Complex;Complication;Consensus;Country;Crohn's disease;Cryopreservation;Cues;Degenerative Disorder;Development;Disease;Doctor of Medicine;Environment;Europe;Exposure to;Fibrin Tissue Adhesive;Future;Generations;Goals;gut inflammation;Human;ileum;Immune;Immunology;immunoregulation;Immunosuppression;Impairment;improved;Individual;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Interferon Type II;Investigation;Laboratories;Location;Lymphoid;Managed Care;manufacture;manufacturing technology;Marrow;Mediating;medical schools;Mesenchymal;Mesenchymal Stem Cells;mesenchymal stromal cell;Mission;Molecular;Nature;novel;Organoids;pathogen;Patients;Pattern;Pharmacologic Substance;Phase;phase III trial;Phenotype;Physicians;pre-clinical research;Procedures;programs;Property;Public Health;Publications;Publishing;Quality of life;Rectum;regenerative;regenerative approach;Regenerative Medicine;regenerative therapy;Research;response;RNA;rural area;rural healthcare;Safety;Science;side effect;single-cell RNA sequencing;stem;stem cell function;stem cell population;stem cell therapy;Stromal Cells;Students;success;System;Technology;Testing;Therapy Clinical Trials;Tissues;transcriptome;treatment response;underserved area;Universities;university student;Variant;Visit

PROJECT_TITLE: Investigation of Human Gut-Derived Mesenchymal Stem Cells for Cellular Therapy

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AKRON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF AKRON

PHR: PROJECT NARRATIVE This research project is aimed at developing a 3D cardiac tissue model with adult heart like physiological properties, which will significantly advance the fields of human cardiotoxicity screening, disease modeling and new treatment development for patients with cardiovascular diseases. Specifically, this research investigates the effects of vascularization, cardiac extracellular matrix and mechanical stimulation on the maturation of cardiomyocytes derived from induced pluripotent stem cells. The results of this project will lead to a novel engineered cardiac tissue consisting of three major cardiac cell types and vascularized cardiac extracellular matrix with the unique advantages of high cell density and functional maturation.

PI_NAMEs: ZHANG, GE  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Affect;Biocompatible Materials;Biological Models;Bioreactors;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac tissue engineering;Cardiotoxicity;Cardiovascular Diseases;Cell Culture Techniques;Cell Density;cell type;Cells;Cellular Morphology;Control Groups;Custom;density;Development;Disadvantaged;disease model;drug development;drug testing;Endothelial Cells;Engineering;experience;Extracellular Matrix;fabrication;fetal;Fibrin;Fibroblasts;Film;Genetic;Goals;Harvest;Heart;Heart Diseases;heart function;Human;Human Engineering;human induced pluripotent stem cells;Hydrogels;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Knowledge;Legal patent;Mechanical Stimulation;Methods;monolayer;Myocardium;novel;novel therapeutics;Outcome;Pathologic;Patients;pharmacologic;Phenotype;Physiological;Play;pre-clinical;Property;regenerative therapy;Research;Research Infrastructure;Research Project Grants;response;Role;screening;spheroids;stem cells;Surface;synergism;Technology;Testing;therapy development;Tissue Engineering;Tissue Model;Tissues;Training;Tube;Underrepresented Students;Universities;Vascularization

PROJECT_TITLE: Maturation Strategies for Engineered Human Cardiac Microtissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-D (80)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Emergency Care;Neurosciences;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stroke

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Florida Regional Coordinating Center for the NINDS Stroke Trials Network The Florida Regional Coordinating Center encompasses a wide regional network of experienced investigators and hospitals across Florida that will enroll a diverse population into clinical studies within the NIH Stroke Trial Network. It will provide access to unique research resources in the areas of preclinical stroke, stem cells, human genomics, and biorepositories that can be leveraged across the network. Through its educational and research opportunities, it will train and enhance the careers of the next generation of stroke clinician scientists and research experts to preserve and expand stroke research expertise.

PI_NAMEs: ROMANO, JOSE G (contact)

PROJECT_TERMS: Acceleration;Acute;acute stroke;Address;Agreement;Animal Model;Area;biobank;Blood Vessels;Brain;career;Caring;Clinical;Clinical Research;clinical trial implementation;Clinical Trials;Collaborations;community setting;Conduct Clinical Trials;Data Coordinating Center;demographics;design;Development;Disparity;Dissemination and Implementation;Education;education resources;Eligibility Determination;Emergency medical service;Emergency Medicine;Enrollment;Ensure;ethnic diversity;experience;Fellowship;Florida;Funding;Future;Genomics;Geography;Goals;Hispanic Populations;Hospitals;human genomics;Immersion;improved outcome;Individual;Infrastructure;Institution;Institutional Review Boards;Intervention;Knowledge;medical schools;member;Mentors;Minority;Mission;Multicenter Studies;multidisciplinary;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;neurological rehabilitation;Neurology;Neurosciences;neurosurgery;next generation;novel;operation;Participant;participant enrollment;patient population;Pediatric Hospitals;Pediatric Neurology;Phase;Policies;Population Heterogeneity;Positioning Attribute;post stroke;pre-clinical;preservation;prevent;Prevention;Privatization;Process;programs;Rare Diseases;Recovery;recruit;Registries;Rehabilitation therapy;Research;research and development;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Scientist;Secondary Prevention;Site;skills;stem cells;Stroke;Stroke Belt;stroke model;stroke therapy;stroke trials;StrokeNet trials;Structure;success;tool;Training;Training Programs;Translating;Translational Research;translational scientist;trial enrollment;United States National Institutes of Health;Universities;Work;working group


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative- Intracerebral hemorrhage (ICH) is a devastating disease in our society, which currently has no validated treatment paradigm leading to improved clinical function. This project will attempt to validate surrogate objective biomarkers on currently, commercially available MRI sequences, to better understand the natural history of ICH in terms of iron- mediated neurotoxicity from 7-10 days to 6 months. This project has immense translational significance as such surrogate markers are lacking and the results will better inform future trials examining novel treatment paradigms to prove their efficacy in ICH.

PI_NAMEs: CHAUDHARY, NEERAJ  (contact);PANDEY, ADITYA S

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Affect;Animal Model;Animals;Anisotropy;Biological Markers;Brain;brain iron;brain tissue;cerebral atrophy;Cerebral Edema;Cerebral hemisphere hemorrhage;Cerebrum;Chronic Phase;Clinical;Clinical Trials;Coagulation Process;Contralateral;Cytolysis;Data;Deferoxamine;Diffusion Magnetic Resonance Imaging;Disease;Edema;Encephalomalacia;Erythrocytes;Evaluation;Family suidae;Fiber;functional improvement;Future;Grant;Health;Hematoma;Hemolysis;Hemorrhage;Histology;Human;image guided;improved;Inflammation;Inflammatory Response;Injury;innovation;Intravenous;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Iron Overload;Lobar;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Mechanics;Mediating;Modeling;mortality;Natural History;Nervous System Physiology;neuron loss;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Patient Recruitments;Patients;pharmacologic;Phase;pre-clinical;Prognosis;prognostication;Recovery;Reporting;Severity of illness;Societies;Surrogate Markers;Techniques;Testing;Therapeutic;Time;Tissues;Variant;white matter;white matter injury;Work

PROJECT_TITLE: Human Intracerebral Hemorrhage: Impact of Hematoma Size, Hemolysis and Iron Overload on Edema and White Matter Survival by MRI

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SPRINGFIELD

ORG_NAME: WESTERN NEW ENGLAND UNIVERSITY

PHR: Project Narrative (3 sentences) High-risk Neuroblastoma (HRNB) is a childhood cancer. The majority of patients with HRNB have tumors that continue to return after numerous treatments. This project will investigate the mechanisms that underlie HRNB tumor recurrence and a novel therapeutic approach to treat relapsed HRNB.

PI_NAMEs: KOOMOA, DANA-LYNN TAKEKO (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Adverse effects;anti-cancer research;Apoptosis;Apoptotic;Attenuated;Autophagocytosis;Biology;Calcium;Calcium Channel;Calcium Signaling;calcium uniporter;Cancer Patient;cancer therapy;Cell Death;Cells;Cephalic;Chemoresistance;Combined Modality Therapy;Complex;cytotoxic;Data;Data Analyses;Dedications;Development;Disease;Disease Progression;Dose;driving force;effective therapy;Electrophysiology (science);experience;Goals;graduate student;high risk;Image;improved;Induction of Apoptosis;inhibition of autophagy;Inhibition of Cell Proliferation;inhibitor;innovation;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentors;Minority Groups;Mitochondria;Nervous System Disorder;Neuroblastoma;neuroblastoma cell;next generation;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Organelles;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Physiological Processes;Play;prevent;Process;Recurrent tumor;Relapse;Research Personnel;Resistance;response;Role;Signal Transduction;targeted treatment;teacher;Testing;Therapeutic;therapy resistant;Time;Tissues;Training;tumor;undergraduate student;Underrepresented Minority;uptake;Work

PROJECT_TITLE: Manipulating Aberrant Calcium Signaling to Target Relapsed High-Risk Neuroblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (81)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Prenatal metal exposures are consistently linked with altered child growth and development, and placental dysfunction is central to these effects. We propose the first study on the impact of metals on the placenta N6- methyladenosine (m6A) epitranscriptome, the ensuing effects on the placental proteome, and child birth outcomes and growth trajectories. Our focus on the placenta—an extraembryonic tissue that is key to early-life programming—will lead to novel insight into the mechanisms governing the effects of prenatal metal exposure and may uncover new molecular targets and biomarkers for treatment and prevention.

PI_NAMEs: KUPSCO, ALLISON  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Adult;Age;Arsenic;Biological;Biological Assay;Biological Markers;Birth;Birth length;Birth Weight;Black race;Body mass index;Cadmium;Cellular Metabolic Process;Child;Child Health;Childbirth;Childhood;cohort;Communities;Data;design;Development;Diet;Education;embryo tissue;epitranscriptome;epitranscriptomics;Exposure to;Fetal Development;Fetus;follow-up;Functional disorder;Gene Expression;Growth;Growth and Development function;Head circumference;Health;Heating;Height;Hispanic;hispanic community;Impairment;in utero;indexing;Inflammation;Inflammatory;innovation;insight;Investigation;Lead;Length;Life;Link;Low Birth Weight Infant;Low income;Low Income Population;Manganese;Maternal Exposure;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolism;metal complex;Metal exposure;metal poisoning;Metals;Modification;Molecular;molecular marker;Molecular Target;Mothers;Names;New York City;novel;Nutrient;Oils;Outcome;Oxidative Stress;Paint;Pathology;Placenta;Placentation;Population;Post-Transcriptional RNA Processing;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;pregnant;prenatal;Prevention;Process;protein biomarkers;protein expression;Proteins;Proteome;Proteomics;Reader;response;Rice;Risk;Risk Assessment;RNA, Messenger, Splicing;Role;Sampling;Selenium;Siblings;Small for Gestational Age Infant;socioeconomics;Soil;Source;Testing;Therapeutic;therapeutic development;Tissues;toxic metal;Toxicant exposure;Transcript;Translations;Urban Community;Waste Products;Weight;Work;Zinc

PROJECT_TITLE: The placental epitranscriptome as a novel mechanism behind prenatal metal mixture exposures and child growth and development

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-S (R1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Millions of people are already at risk of mortality and other adverse health outcomes due to heat stress. The risks are inequitably distributed, with low-income people facing the greatest risks of illness and death due to cardiovascular disease, respiratory infection, respiratory disease, chronic kidney disease, diabetes, and respiratory infections; heat stress can also result in adverse pregnancy outcomes and poor mental health. Without accurately quantifying personal heat stress and evaluating the relative impact of various risk factors, interventions to equitably reduce heat stress on a population level may be ineffective or inefficient. This study will assess personal heat stress in informal settlements in Dhaka, Bangladesh among individuals without access to air conditioning to characterize heat stress, identify housing types associated with heat stress, and evaluate interventions to reduce heat stress indoors.

PI_NAMEs: KWONG, LAURA HSI (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: acceptability and feasibility;Adult;Adverse effects;adverse pregnancy outcome;Affect;Age;Air Conditioning;Asia;Bangladesh;behavior change;Biological Markers;Blood Pressure;Capital;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cessation of life;Characteristics;Chronic Kidney Failure;chronic respiratory disease;climate change;Communities;comorbidity;cost;cost effective;cost effective intervention;cost effectiveness;Country;Death Rate;design;Diabetes Mellitus;disability-adjusted life years;Disease;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Elderly;Equity;Event;experience;experimental study;extreme heat;Face;Fatigue;Frequencies;Gender;Goals;Health;health equity;health inequalities;Heart Rate;Heat Stress;Heterogeneity;high risk;Home;home test;Household;Housing;Hypertension;Income;Individual;Inequity;Infrastructure;Intervention;intervention cost;Iron;Kidney;Low income;Low Income Population;Lower Respiratory Tract Infection;Mental Health;model building;Modeling;Modification;Morbidity - disease rate;mortality;mortality risk;Needles;Occupations;Outcome;Patient Self-Report;Persons;Phase;Population;predictive modeling;pregnant;prevent;primary outcome;Productivity;Randomized, Controlled Trials;Recommendation;Research;respiratory;Respiratory Disease;Respiratory Tract Infections;Risk;Risk Factors;secondary outcome;Severities;sex;Slum;Subgroup;Technology;Temperature;Testing;Variant;Vulnerable Populations

PROJECT_TITLE: Understanding heat stress and adverse health outcomes in vulnerable populations in Bangladesh: Can we move the needle by designing low-cost, feasible and culturally acceptable interventions?


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Having formerly received a one year G13 Award stretched over a second year as no- cost-extension (2014-2016), the PI now proposes to complete the book “Glial Cell Biology: An Historical Perspective” started a decade ago. As Editor and author responsible for most of this novel historical work written from scratch with 22 other contributors, she needs another year of support to finish the 24 chapters and complete production of this 2- volume book.

PI_NAMEs: BOULLERNE, ANNE ISABELLE (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Applications Grants;Artificial Intelligence;Award;Books;cell type;Cellular biology;Computers;Consensus;Consumption;cost;digital;Explosion;First Name;Funding;Goals;Humanities;Iceberg;insight;Letters;Literature;Manuscripts;Mediation;Microglia;Mind;Morphologic artifacts;neglect;Nerve;Nervous System;Nervous System Disorder;Neuroglia;Neurons;Neurosciences;novel;Portraits;Production;Public Domains;Publishing;Recording of previous events;Request for Applications;Research;Role;Shoulder;Source;Stretching;Time;Translating;Update;Work;Writing

PROJECT_TITLE: Completing Glial Cell Biology: A Historical perspective

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-P (02)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW ORLEANS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Advanced age and cigarette smoking (CS) are the top non-genetic risk factors for age-related macular degeneration (AMD). The extent that aging and CS drive mitochondrial dysfunction and variable RPE phenotypes is still unclear, representing significant scientific knowledge gap in the field. This proposal will characterize the cellular and molecular features of disease-causing subtypes in RPE cells, including epithelial mesenchymal transition (EMT), senescence, and cell death, and link those with the severity of mitochondrial dysfunction associated with aging and CS in both animal models and human AMD samples.

PI_NAMEs: HANDA, JAMES T;WANG, SHUSHENG  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age;Age related macular degeneration;age-related disease;Aging;Animal Model;Antioxidants;Biogenesis;biological adaptation to stress;Cell Cycle Arrest;Cell Death;Cells;Cessation of life;Chronic;cigarette smoke;cigarette smoking;Data;Disease;Elderly;Epithelium;FRAP1 gene;Functional disorder;Goals;Heterogeneity;Human;Impairment;Injury;Knowledge;Link;Malignant Neoplasms;Measures;Mediating;Mesenchymal;Metabolic stress;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mTOR Signaling Pathway;Mus;Nicotinamide Mononucleotide;non-genetic;non-smoker;Nonexudative age-related macular degeneration;Nuclear;Oxidative Stress;Pathogenicity;Pathologic;Pathology;Peripheral;Phenotype;Phosphoric Monoester Hydrolases;Physical condensation;Physiological;PINK1 gene;preservation;prevent;Process;programs;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;Reporting;response;retinal rods;Risk;Risk Factors;Sampling;senescence;senescent cell;Severities;Signal Transduction;Small Nuclear RNA;Smoker;Smoking;Stress;Structure of retinal pigment epithelium;Subgroup;Testing;therapeutic target;tissue degeneration;tissue stress;transcriptome;Variant;Virulence Factors;Visualization

PROJECT_TITLE: Does age/stress-induced mitochondrial dysfunction induce variations in RPE phenotype in AMD?

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The Fanconi Anemia protein, FANCV/REV7, cooperates in several DNA repair functions including crosslink repair, DSB repair, and telomere maintenance. The D’Andrea laboratory has recently demonstrated that FANCV/REV7 binds to the CHAMP1 complex, a heterochromatic complex consisting of CHAMP1, POGZ, and HP1a. This grant will evaluate the role of this protein complex in DNA repair and its requirement in telomere length maintenance in human tumor cells with the ALT pathway.

PI_NAMEs: D'ANDREA, ALAN D. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acceleration;Adopted;Alleles;Binding;Binding Proteins;Characteristics;Chromosomal Instability;Chromosomes;Clinical;Complex;crosslink;diagnostic tool;Disease;DNA crosslink;DNA Repair;DNA Repair Gene;drug sensitivity;established cell line;Excision;Fanconi anemia protein;Fanconi Anemia-BRCA Pathway;Fanconi's Anemia;Genes;Germ Lines;Grant;Heterochromatin;Heterozygote;homologous recombination;Human;hydroxyurea;Inherited;Intellectual functioning disability;Kinetochores;knock-down;Laboratories;Length;Malignant Neoplasms;Microtubules;Molecular;Molecular Conformation;Mutation;neoplastic cell;Nonhomologous DNA End Joining;novel diagnostics;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Lymphocyte;Phenotype;Process;protein complex;Proteins;recombinational repair;recruit;Regulation;repair function;repaired;Role;Seat Belts;senescence;Site;Structure;Syndrome;targeted cancer therapy;Telomerase;telomere;Telomere Length Maintenance;Telomere Maintenance;Telomere Pathway;Telomere Shortening;tumor;Zinc Fingers

PROJECT_TITLE: Molecular Pathogenesis of Fanconi Anemia

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: WELLESLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WELLESLEY COLLEGE

PHR: PROJECT NARRATIVE  High-throughput sequencing experiments can provide information about gene expression in human pathogens during infection, but existing computational methods for processing the information are insufficient. In this project, computational tools and methods will be developed for analyzing high-throughput sequencing data, and these new methods will be evaluated on data collected from various bacterial organisms. More broadly, the computational infrastructure developed in this project will serve as a resource to biological and medical researchers studying myriad bacteria that are human pathogens.

PI_NAMEs: TJADEN, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithmic Analysis;Algorithms;annotation  system;Area;Bacteria;Bacterial Genome;Bacterial RNA;Biological;biological research;Cells;Clip;Code;comparative genomics;Complement;Computer Analysis;computer infrastructure;computerized data processing;computerized tools;Computing Methodologies;Data;Data Analyses;data integration;Data Set;deep sequencing;design;Escherichia coli;experimental study;Family;Gene Expression;Genes;Genetic Transcription;Genome;genome browser;Goals;heterogenous data;high throughput analysis;High-Throughput Nucleotide Sequencing;human pathogen;improved;Individual;Infection;informatics tool;information processing;Maps;Medical;Medical Research;Messenger RNA;Methods;Modeling;novel;novel strategies;Open Reading Frames;Operon;Organism;Overlapping Genes;Performance;Process;Proteins;rapid growth;reference genome;Regulation;Research Personnel;research study;Resolution;Resources;RNA;RNA Splicing;Running;single-cell RNA sequencing;Small RNA;Streptococcus pyogenes;support tools;System;Systems Analysis;Technology;Testing;Time;Tissue-Specific Gene Expression;tool;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA;user-friendly;Visualization

PROJECT_TITLE: System and Methods for Analysis of Bacterial Transcriptomes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Project Narrative Our overall objective is to unravel T cell development throughout a bat's lifespan, leading to long-term viral suppression via adaptive immunity. Fundamentally, T cells arise from the bone marrow, they then migrate to thymus where they develop into naïve T cells, that circulate in peripheral tissues and blood - where they act as 'sentinels cells’ (e.g., CD4+ helper, CD8+ cytotoxic) that suppress viral infection. However, after 100 years of anatomical study in bats, the role of the thymus in T cell development has not been described, nor has how T cell development occurs in the thymus or other lymphoid organ, which is the fundamental tenet of T cell immunology.

PI_NAMEs: THOMPSON, CODY WELFORD;WHITE III, RICHARD ALLEN (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adaptive Immune System;adaptive immunity;Address;Adolescent;Adult;Age;age related;American;analytical tool;Anatomy;Animals;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Response;Antibodies;Antibody Repertoire;antiviral immunity;B-Cell Activation;B-Cell Development;Biology;Black Box;Blood;Bone Marrow;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Maturation;Cells;Cessation of life;Chiroptera;Clinical;Coronavirus;COVID-19 pandemic;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Development;Ebola;experience;fighting;Flow Cytometry;Fluorescence;Genes;Genetic Recombination;Goals;Health;Henipavirus;Histologic;Histology;Home;Image;Immune;Immune system;immune system function;Immunity;Immunohistochemistry;Immunologic Memory;Immunologics;Immunology;Immunotherapy;In Situ Hybridization;Infection;insight;Knowledge;Laboratories;life span;Link;Location;lymph nodes;lymphatic duct;lymphoid organ;Lymphoid Tissue;Mammals;Marburgvirus;Measures;Mediating;Messenger RNA;Methods;migration;Molecular;multiple omics;Museums;next generation;Nipah;Organ;Organism;pathogen;pathogenic virus;Pathogenicity;Pathology;Peripheral;Pharmaceutical Preparations;Planet Earth;Predisposition;primary lymphoid organ;Process;programs;Rabies;Reagent;Regulation;Research;response;RNA Viruses;Role;Scientist;secondary lymphoid organ;Sentinel;Severe Acute Respiratory Syndrome;sex;sexual dimorphism;single molecule;single-cell RNA sequencing;Site;Specialist;Specimen;Spleen;stem cells;Structure;Symptoms;T cell receptor repertoire sequencing;T-Cell Development;T-cell receptor repertoire;T-Lymphocyte;Techniques;Testing;Thymus Gland;Tissues;Training;Training and Education;transcriptome sequencing;undergraduate student;Vaccines;Viral;virology;Virus;Virus Diseases;Visualization software;voucher;Work;X-Ray Computed Tomography

PROJECT_TITLE: BITE (Bat Immunology Training and Education) - an undergraduate experiential program for developing the next generation of One Health scientists

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]