NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Among patients with diabetes, 15% develop a foot ulcer, and 12-24% of individuals with a foot ulcer require amputation. This proposal seeks continuation of an established Clinical Research Unit (CRU) participating in the NIH Diabetic Foot Consortium (DFC). DFC conducts clinical research on Americans with diabetic foot ulcer (DFU) with the goal to improve care and minimize amputation.

PI_NAMEs: GORDILLO, GAYLE M;ROY, SASHWATI ;SEN, CHANDAN K (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Active Sites;Address;American;Amputation;Area;Award;biobank;Biological Markers;biomarker validation;c-myc Genes;care delivery;care providers;Caring;Clinical;clinical center;Clinical Research;clinical research site;Communication;cost;Darkness;Dedications;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Discipline;Enrollment;Ensure;Environment;Exclusion Criteria;experience;Extramural Activities;Foot Ulcer;Fostering;Funding;Goals;healing;Health;Health system;Home;Hospitals;Human Resources;improved;Indiana;Individual;Infrastructure;innovation;Institution;Interdisciplinary Education;Interdisciplinary Study;Leadership;medical schools;Methodist Church;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nomenclature;pandemic disease;Participant;patient oriented;patient population;Patient Recruitments;patient retention;Patient-Focused Outcomes;Patients;Performance;Podiatry;Procedures;Productivity;programs;Protocols documentation;Qualifying;Readiness;recruit;Recurrence;Resources;response;Rights;Safety;Schedule;Secure;Site;social health determinants;success;Time;Training;Translational Research;Travel;United States National Institutes of Health;Universities;Visit;Water;wound;wound care;wound healing

PROJECT_TITLE: Diabetic Foot Consortium Clinical Research Unit


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Genome mining of natural products from sequenced microbial genomes is a promising strategy to new human therapeutics. To increase our abilities in performing genome mining, this MIRA proposal will i) fundamentally understand the enzymology of biosynthetic enzymes that make natural products; and ii) develop more effective methods of mining with a particular emphasis on using resistance enzymes to prioritize biosynthetic pathways that may produce natural products of desired biological activities.

PI_NAMEs: TANG, YI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Area;bioactive natural products;Biological;Chemical Structure;Cyclization;Educational process of instructing;Enzymatic Biochemistry;enzyme activity;Enzymes;Family;Fungal natural products;Gene Cluster;Genome;Grant;Human;Investigation;Knowledge;Link;Metabolism;Methods;microbial genome;Microbial Genome Sequencing;Mining;Molds;Natural product discovery;Natural Products;Natural Resistance;Nature;Organism;Pathway interactions;programs;protein transport;Proteins;Renaissance;Research;Research Activity;Resistance;Resistance development;resistance gene;resistance mechanism;Structure;synthetic biology;Therapeutic;tool;Variant

PROJECT_TITLE: MIRA: Enzymology and Self-Resistance of Natural Product Biosynthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(07)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Acinetobacter baumannii has emerged as a bacterial pathogen of immense healthcare concern due to increases in frequency and severity of infection, combined with the organism’s ability to resist front-line antibiotics. A. baumannii antibiotic resistance is predominantly attributable to expression of members of its expansive repertoire of drug efflux pumps that extrude antibiotics from the cell. This project will develop broad spectrum efflux pump inhibitors (EPI) that reduce or eliminate the organism’s ability to efflux multiple classes of antibiotics.

PI_NAMEs: DUNMAN, PAUL M. (contact);FLAHERTY, DANIEL PATRICK

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Address;Adjuvant;Aminoglycosides;analog;antibiotic efflux;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;benzenesulfonamide;beta-Lactams;Biological;Biological Assay;Carbapenems;Cells;cellular targeting;Chemicals;Chemosensitization;Clinic;Clinical;Communicable Diseases;Compensation;Death Rate;design;Disease Outbreaks;Drug Efflux;Drug Kinetics;efflux pump;ESKAPE pathogens;Exhibits;extensive drug resistance;Failure;Family;Fluoroquinolones;Frequencies;Genetic;glycylcycline;Goals;Growth;Healthcare;high throughput screening;Human;improved;in vivo;in vivo evaluation;in vivo Model;Incidence;Infection;inhibitor;innovation;interest;Laboratories;lead optimization;Libraries;Mediating;member;Molecular;mouse model;Multi-Drug Resistance;Mutation;Organism;overexpression;pathogen;pathogenic bacteria;patient population;Patients;Pharmaceutical Chemistry;Phenotype;Physiological;Property;Pump;Reducing Agents;Reporting;Resistance;Resistance development;resistant strain;resistome;response;scaffold;screening;Septicemia;Series;Serum;Severities;small molecule;Societies;Structure;System;Systemic infection;Tetracyclines;Therapeutic Agents;tigecycline;Toxic effect;Translations;Up-Regulation;ventilator-associated pneumonia;World Health Organization

PROJECT_TITLE: Inhibitors of adaptive efflux mediated resistance in Acinetobacter baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(02)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Genetics;Nutrition

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Narrative This project aims to test the effect of follistatin (Fst)-induced white adipose browning on the regulation of lipoprotein homeostasis and progression of atherosclerosis. We will utilize various mouse models with targeted manipulation of Fst tissue and systemic levels to identify key targets of Fst and explore its therapeutic potential for the treatment dyslipidemia, atherosclerosis and related metabolic diseases.

PI_NAMEs: SINGH, RAJAN  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: 3T3-L1 Cells;Adipocytes;adiponectin;Adipose tissue;Adult;Animal Model;Antiatherogenic;Aorta;Applications Grants;Area;arginase;Arginine;Arterial Fatty Streak;Atherosclerosis;beta-adrenergic receptor;Cardiovascular Diseases;Cholesterol;Data;Data Correlations;Data Set;Dependovirus;Development;Diet;Drug Design;Dyslipidemias;Energy Metabolism;enzyme pathway;FGF21 gene;fibroblast growth factor 21;Follistatin;Gene Chips;Gene Expression;Generations;Genes;Genetic;genetic approach;genetic variant;Grant;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Homeostasis;Human;human subject;Hybrids;Immunoprecipitation;inhibitor;insight;Laboratories;LDL Cholesterol Lipoproteins;Lesion;lipid metabolism;lipidomics;lipoprotein cholesterol;Lipoproteins;Liver;Low Density Lipoprotein Receptor;LoxP-flanked allele;MAP Kinase Gene;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mus;Nonesterified Fatty Acids;NOS2A gene;novel;novel therapeutics;Ornithine;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Peptides;pharmacologic;Phenylalanine;Phosphorylation;Plasma;Play;programs;promoter;Property;Proprotein Convertases;protein expression;Proteins;Public Health;Publishing;Receptors, Adrenergic, beta-1;Regulation;Reporting;reverse cholesterol transport;RNA Sequence Analysis;Role;Signal Pathway;Signal Transduction;System;Testing;Therapeutic;therapeutic target;therapy design;Thermogenesis;Time;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Organisms;Triglycerides;uncoupling protein 1;Viral Vector;Work

PROJECT_TITLE: Follistatin regulation of energy and lipid metabolism during progression of atherosclerosis


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Genetics;Nanotechnology

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This proposal aims to elucidate the mechanisms of a viral DNA packaging motor by an integrated cryo-electron microscopy (cryo-EM) and computational approach and to leverage the gained knowledge to assemble a functional motor complex in a lipid membrane. The proposed research will provide a foundation for the design of antiviral drugs and for the fabrication of artificial nanomotors for diagnostics and drug delivery.

PI_NAMEs: CHENG, XIAOLIN  (contact);GUO, PEIXUAN

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adenosine Triphosphate;analog;Anti-viral Agents;Architecture;ATP phosphohydrolase;Bacteriophages;Biochemical;Biomimetics;Cell Physiology;Chemicals;Complex;crosslink;Cryoelectron Microscopy;Data;design;Development;Diagnostic;DNA;DNA Packaging;Drug Delivery Systems;ds-DNA;Energy-Generating Resources;Engineering;experimental study;fabrication;Fingerprint;Foundations;Free Energy;Future;Genome;Glean;Goals;Image Analysis;In Situ;In Vitro;Individual;insight;Knowledge;Link;Lipid Bilayers;Maps;Mechanics;Membrane Lipids;mimetics;Modeling;Molecular;Molecular Biology;Molecular Conformation;molecular dynamics;Motion;Motor;movie;mutant;nano;nanomedicine;Nanotechnology;Nature;operation;Proteins;Protocols documentation;reconstitution;Reporting;Research;Resolution;Rotation;simulation;single molecule;Specimen;stoichiometry;Structure;success;System;Techniques;Thermodynamics;Viral;viral DNA;Viral Genome;viral genomics;Viral Packaging;Work

PROJECT_TITLE: Dissect the molecular mechanism of a viral genome packaging motor by an integrated structural approach

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: AMHERST

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: To adapt to diverse environments, bacteria produce many different molecules that can also possess antibiotic, anticancer, or other important activities. We will examine how these molecules are made by a family of specialized proteins that utilize a remarkable assembly line architecture. Understanding the features that govern the activities of these proteins will provide new opportunities to discover and create new drug molecules.

PI_NAMEs: GULICK, ANDREW M (contact)

PROJECT_TERMS: Amino Acids;Anabolism;anti-cancer;Antibiotics;Architecture;Bacteria;beta-Lactams;Binding;Biochemical;Biological;Catalytic Domain;Cephalosporins;chemical reaction;Chemicals;Communication;Cyclosporins;Endowment;Enterobactin;Environment;Enzymes;Face;Family;Gene Cluster;human pathogen;Immunosuppressive Agents;Individual;Length;Messenger RNA;Microbe;Modification;Molecular;Molecular Conformation;Mutagens;mycobactins;natural product derivative;Natural Products;novel therapeutics;Nutrient;Organism;Penicillins;Peptide Antibiotics;peptide natural products;peptide synthase;Peptide Synthesis;Pharmaceutical Preparations;Pharmacologic Substance;Physical condensation;Play;Process;Property;Proteins;pyoverdin;Ribosomes;Role;Siderophores;Signal Transduction;small molecule;Structure;Tertiary Protein Structure;thioester;unnatural amino acids;Vancomycin;Virulence

PROJECT_TITLE: Structural Studies of Nonribosomal Peptide Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Our lab studies how G proteins within the cell are produced with the help of a set of chaperones called Ric-8 proteins and are activated by a class of cell membrane-spanning receptor molecules, called adhesion GPCRs that sense or adhere to neighboring cells or the mesh network that surrounds cells. Our proposed work will use cutting edge techniques to solve the structures of Ric-8 / G protein complexes in order to deduce the mechanism of how they help fold or produce G proteins. We recently worked with collaborators to solve the structure of self-activating adhesion GPCRs engaged with G proteins and from this, we propose a series of experiments using protein biochemistry, cell biology and genetic mouse models to determine the mechanisms of how adhesion GPCRs become activated.

PI_NAMEs: TALL, GREGORY GORDON (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: ADGR1 gene;Adhesions;Agonist;Biochemical;Biological;Blood;Blood Platelets;Cell Adhesion;Cell membrane;cell type;Cells;Cellular biology;Complex;Disease;Dissociation;Drosophila genus;Elements;Event;experimental study;extracellular;Extracellular Matrix;Family;Family member;G-Protein-Coupled Receptors;Genetic;Goals;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Guanine Nucleotides;Heterotrimeric GTP-Binding Proteins;in vivo;Investigation;Ligands;member;Molecular Chaperones;mouse model;Protein Biochemistry;protein complex;Proteins;receptor;response;Series;Signal Transduction;Specificity;Structure;Substrate Specificity;Sum;System;Techniques;Transmembrane Domain;Work

PROJECT_TITLE: Investigation of Adhesion GPCR and Ric-8 protein control of heterotrimeric G proteins

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Sensory processing provides an opportunity for us to understand how neural circuits represent information from the external world, but we know relatively little about how non-sensory internal factors such as arousal, spontaneous movements, and cognition can alter the perception of stimuli. This research proposal will reveal the influence of these non-sensory factors on the primary visual thalamus during active visual perceptual behavior. The overall outcomes of this proposal will underscore a need for the field to take into account how internal factors such as arousal, task-engagement, and visual spatial attention impact early visual signaling before reaching cortex.

PI_NAMEs: PEELMAN, KAYLA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Accounting;Animals;area striata;Arousal;Attention;attentional modulation;Automobile Driving;awake;Behavior;behavior prediction;Behavioral;behavioral outcome;Brain;Brain region;Cognition;Cognitive;Data;Detection;Diameter;Dissociation;Dorsal;Drowsiness;Electrophysiology (science);Environment;experimental study;extracellular;Face;Frequencies;Head;improved;in vivo;Investigation;Knowledge;Lateral Geniculate Body;Linear Models;Measures;Methods;Monitor;Motor Activity;Movement;Mus;Mydriasis;neural;neural circuit;Neurons;Neurosciences;novel;Outcome;Perception;Performance;Population;Property;Pupil;Research Proposals;response;Retina;Running;segregation;Sensory;sensory cortex;sensory input;sensory system;Signal Transduction;Speed;Stimulus;System;Testing;Thalamic structure;Training;Visual;visual information;visual processing;visual stimulus;Visuospatial;Work

PROJECT_TITLE: The impact of behavioral state and spatial attention on sensory responses in the primary visual thalamus


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Up to half of adults will experience a traumatic event in their lifetimes and up to half of patients seeking treatment for substance use disorders have PTSD, and these individuals have worse treatment outcomes for both conditions. Opioid use disorder (OUD) is a common sequela following trauma and is highly comorbid with PTSD. Here we aim to test the overarching hypothesis that following a traumatic event, the opioid system becomes dysregulated in the bed nucleus of the stria terminalis leading to heightened anxiety and risk for opioid use disorder.

PI_NAMEs: ROSAS-VIDAL, LUIS EDUARDO (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: addiction;Adult;Amygdaloid structure;Anatomy;Anti-Anxiety Agents;Anxiety;anxiety reduction;anxiety states;avoidance behavior;Behavior;Behavioral Model;Behavioral Sciences;Biological;Biological Assay;Calcium;career;career development;Cells;Chronic;comorbidity;coping;Data;Data Analyses;design;Development;Development Plans;Disease;Electrophysiology (science);emotional distress;endogenous opioids;Ensure;Environment;Etiology;experience;Experimental Designs;experimental study;Exposure to;Freezing;Fright;Future;gamma-Aminobutyric Acid;genetic approach;Hypothalamic structure;Image;in vivo;Individual;Infusion procedures;insight;Knowledge;Laboratory Finding;Lateral;Link;Mediating;member;Mental disorders;Mentors;Methods;Morphine;mu opioid receptors;mu receptors;Mus;Negative Reinforcements;neural;neural circuit;Neurobiology;Neurons;North Carolina;novel;Odors;Opioid;opioid misuse;opioid use;opioid use disorder;optogenetics;Output;Patients;Physicians;Post-Traumatic Stress Disorders;professor;Psychiatry;Receptor Activation;Receptor Signaling;recruit;Regulation;Research;Resources;response;Risk;Role;Scientist;Self Medication;Signal Transduction;Slice;Stress;stress reactivity;stress related disorder;Structure of terminal stria nuclei of preoptic region;Substance Use Disorder;substance use treatment;Symptoms;Synapses;System;tenure track;Testing;Thinking;Time;Training;transmission process;Trauma;traumatic event;traumatic stress;Treatment outcome;Universities;Viral;Vulnerable Populations

PROJECT_TITLE: Opioid-BNST interactions in the regulation of trauma-induced anxiety states

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The purpose and objectives of the training program proposed for continued support remain the same: to prepare bioengineers for an impactful career in orthopaedic research as part of a focused program leading to the Ph.D. degree in Bioengineering. Training a diverse cohort of bioengineers side-by-side with orthopaedic surgeons and life scientists, will continue to foster an environment conducive to research and education in the orthopaedic arena. Indeed, this has been the formula that has been very successful in our training program thus far and, in today's complex and interdisciplinary research world, this approach is more essential than ever.

PI_NAMEs: MAUCK, ROBERT L;SOSLOWSKY, LOUIS J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Training Program in Musculoskeletal Research


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative High-risk neuroblastoma is characterized by amplifying the MYCN gene and deleting the 1p36 (D1p36) region of chromosome one, which houses multiple tumor suppressors. This proposal will test the hypothesis that the INTS11 protein is a potentially novel target in high-risk neuroblastoma. To that end, we will utilize a combination of INTS11 knockdown and small molecule inhibitors to determine if neuroblastoma cells are uniquely dependent on INTS11 for viability.

PI_NAMEs: WAGNER, ERIC J (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: 1p36;Anabolism;Biological;Cell Line;Cell Proliferation;Cells;Child;Chromosomes;Code;Complex;Coupled;Data;Dependence;design;Diagnosis;Down-Regulation;druggable target;Endoribonucleases;FDA approved;Gene Expression;Genes;Genetic Transcription;Genomics;high risk;high throughput screening;Infant;inhibitor;knock-down;Laboratories;Malignant Neoplasms;Measures;member;Molecular;mRNA Precursor;Mutation;MYCN gene;Neuroblastoma;neuroblastoma cell;new therapeutic target;Normal Cell;novel;Output;patient prognosis;Pharmaceutical Preparations;pharmacologic;Precision Run-On Sequencing;Property;Proteins;Reagent;Recycling;Reporter;Research;Research Project Grants;RNA;RNA Polymerase II;RNA Processing;RNA Splicing;Role;small hairpin RNA;small molecule;small molecule inhibitor;Spliceosomes;Survival Rate;System;Testing;Toxic effect;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumorigenicity;United States;virtual

PROJECT_TITLE: Probing INTS11 as a novel target in neuroblastoma


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a complex genetic disease caused by genetic and environmental factors. Genome- wide association studies have identified hundreds of small genome sequence changes—called DNA sequence variants—that are associated with increased risk of developing T2D, but how these variants affect the ability of pancreatic cells to respond to stress is unknown. This project will assess how T2D-associated variants impact the ability of pancreatic cells to respond to stress related to the burdens of making and secreting insulin, and the findings are expected to broadly enhance our understanding of how T2D-associated variants affect sensitivity to other forms of cellular stress and promote T2D.

PI_NAMEs: BHUIYAN, REDWAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3-Dimensional;Affect;ANXA5 gene;ATAC-seq;Beta Cell;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biological Process;Blood Glucose;blood glucose regulation;career;Cell Death;Cell Nucleus;Cell Physiology;Cell Survival;cell type;Cells;cellular resilience;Cellular Stress;Cessation of life;Chemicals;Chromatin;CISH gene;Clinical Skills;collaborative environment;Color;Communication;Complex;Coupled;CRISPR/Cas technology;Data;Data Analyses;Development Plans;Disease;DNA Sequence;doctoral student;Electrophoretic Mobility Shift Assay;endoplasmic reticulum stress;Environmental Risk Factor;environmental stressor;epigenome editing;Etiology;European;Exhibits;experience;Exposure to;Failure;Fellowship;Fluorescein-5-isothiocyanate;Fluorescence-Activated Cell Sorting;Functional disorder;functional genomics;Future;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Diseases;Genetic Risk;Genetic study;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;genome-wide;Genomic medicine;Genomics;Goals;Health;Hi-C;Human;in vivo;innovation;Insulin;Insulin Resistance;insulin secretion;islet;Islet Cell;Islets of Langerhans;Knowledge;Link;Maps;Measures;Mediating;Mentors;Meta-Analysis;Metabolic;Molecular;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pancreas;Pathway interactions;Patients;Phase;Phenotype;Physicians;physiologic stressor;Physiology;Positioning Attribute;precision genomic medicine;Process;programs;promoter;Proteins;Publishing;Quantitative Trait Loci;Regulatory Element;Reporter;Research;response;Risk;risk variant;Role;Scientist;sensor;Signal Transduction;Single Nucleotide Polymorphism;skills;Stains;Stress;stress resilience;Techniques;Testing;Thapsigargin;The Jackson Laboratory;Time;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;Tunicamycin;Untranslated RNA;Variant;Work

PROJECT_TITLE: Dissecting the roles of type 2 diabetes-associated variants and effector genes in islet endoplasmic reticulum stress response


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The project will test the effect of a drug that is already approved for human use in animal models of stroke. The drug increases the levels of a compound in brain that protects against brain injury after stroke using multiple mechanisms of action. If the results are positive, the drug can be advanced rapidly for testing in human clinical trials and approval for use in stroke patients.

PI_NAMEs: ALKAYED, NABIL J (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Acute;Aneurysmal Subarachnoid Hemorrhages;Animal Model;Arachidonic Acids;Award;Blinded;Brain;Brain hemorrhage;Brain Injuries;Cerebral Ischemia;Clinical Trials;Critical Illness;Cytochrome P450;Cytochromes;Cytoprotection;Diabetes Mellitus;diabetic;Dose;efficacy testing;efficacy validation;Eicosanoids;Enzymes;Epoxide hydrolase;experience;Experimental Designs;FDA approved;Female;functional improvement;functional outcomes;gain of function mutation;Gene Deletion;genetic association;Goals;Human;Hydrolase;Hypertension;improved;improved outcome;in vivo;Infarction;Inflammation;inhibitor;Ischemic Brain Injury;Ischemic Stroke;lipid mediator;Lipoxygenase;loss of function mutation;male;meeting abstracts;meetings;Membrane;Metabolism;Middle Cerebral Artery Occlusion;Modeling;Mus;National Institute of Neurological Disorders and Stroke;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;old mice;Oral Administration;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Phase Ib Clinical Trial;Phospholipids;Physiological;Platelet aggregation;Play;post stroke;pre-clinical assessment;programs;Progress Reports;Prostaglandin-Endoperoxide Synthase;Protocols documentation;Publications;Randomized;Reperfusion Injury;Research Contracts;Risk;Rodent;Role;Safety;Science;Signaling Molecule;Site;Solubility;Stroke;stroke model;stroke outcome;stroke patient;stroke risk;Subarachnoid Hemorrhage;Testing;Therapeutic;timeline;translational study;trend;Update;Validation;Vasodilation;Work;young adult

PROJECT_TITLE: Soluble Epoxide Hydrolase Inhibitor GSK2256294 for Acute Ischemic Stroke


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Hereditary Hemorrhagic Telangiectasia (HHT) is a debilitating genetic disorder characterized by enlarged, leaky small vessels (telangiectasias) and inappropriate, fragile connections between arteries and veins called arteriovenous malformations (AVMs), which can rupture leading to aneurysms, stroke and even death. There is an urgent need to develop disease-modifying interventions that could prevent, stabilize, or even normalize AVMs because there are no drugs for effective treatment in HHT patients, while invasive surgical procedures pose inherent risks. Our studies use established and novel HHT animal models, pharmacological approaches, and molecular-based methods to uncover the mechanistic signaling cascades involved in AVM pathogenesis and identify new drug targets for the therapeutic design and treatment of HHT.

PI_NAMEs: MARAMBAUD, PHILIPPE ;MEADOWS, STRYDER MEDOAH (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: activin receptor-like kinase 1;Affect;Anemia;Aneurysm;Angiogenic Factor;Angiopoietin-2;Angiopoietins;Animal Model;Arteries;Arteriovenous malformation;Blood;Blood Vessels;Brain;causal variant;Cell model;Cessation of life;chemokine;Complex;CXCR4 gene;Data;Defect;design;Development;Disease;druggable target;effective therapy;Endoglin;Endothelial Cells;Exhibits;FDA approved;FOXO1A gene;FRAP1 gene;gain of function;Gene Deletion;gene repression;Genetic;Genetic Diseases;Genetic Transcription;Hemorrhage;Hereditary hemorrhagic telangiectasia;imaging modality;inhibitor;Intervention;Laboratories;Ligands;Link;Liver;loss of function;loss of function mutation;Loss of Heterozygosity;Lung;Mediating;Metabolic;Methods;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Operative Surgical Procedures;Organ;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;PIK3CG gene;Positioning Attribute;prevent;Process;Proteins;Proteomics;receptor;Repression;Retinal Diseases;Risk;Rupture;Signal Pathway;Signal Repression;Signal Transduction;Stroke;targeted treatment;Telangiectasis;Testing;therapeutic target;TIE-2 Receptor;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptomics;Transforming Growth Factor beta;vascular bed;Veins;Work

PROJECT_TITLE: Angiopoietin-2 Signaling Targeted Therapeutics for Arteriovenous Malformations

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Impaired juxtacrine signaling implicates many developmental defects and diseases including cancer, multiple sclerosis, and lymphoma, and neurodegenerative diseases, and thus understanding of the spatiotemporal dynamics of juxtacrine signaling including Notch and Neuroligin will not only provide important insights in the molecular mechanisms of the pathogenic processes, but also be beneficial for diagnostic and therapeutic purposes.

PI_NAMEs: JUN, YOUNG-WOOK  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Atomic Force Microscopy;Binding;Cell Communication;Cells;Chemicals;Cues;Defect;Detection;Development;Diagnostic;Diffusion;Disease;Event;Immune;Impairment;Individual;insight;intercellular communication;Investigation;Knowledge;Lymphoma;Magnetism;Malignant Neoplasms;mechanical properties;mechanical signal;mechanotransduction;Mediating;Molecular;Monitor;Multiple Sclerosis;Nanotechnology;nanotechnology platform;Neurodegenerative Disorders;new technology;notch protein;Pathogenicity;Process;Property;protein protein interaction;Quantum Dots;receptor;Reporting;response;Signal Transduction;Signaling Protein;single molecule;spatiotemporal;stem;synaptic function;synaptogenesis;Technology;technology platform;Therapeutic;Tissues;tool

PROJECT_TITLE: Spatiotemporal interrogation of molecular mechanobiololgy at the cell-cell interface with nanotechnology tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Prevention;Rehabilitation

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative How infants learn to progress from spontaneous and seemingly disorganized movements into goal-directed and refined motor skills is unknown. Until we understand how to promote successful infant learning, we cannot design optimal early intervention for infants with or at risk of neuromotor developmental disabilities. The objectives of this project are to 1) determine the relationship between error rate and the development of reaching skill in infants with typical development, 2) identify individual and environmental factors related to the development of skilled reaching in infants with typical development, 3) identify patterns of concurrent brain activity that differentiate between spontaneous arm movements, early reaching attempts, and skilled reaches in infants with typical development, and 4) identify patterns of concurrent brain activity that differentiate between spontaneous arm movements, early reaching attempts, and skilled reaches in infants at high risk for cerebral palsy.

PI_NAMEs: SMITH, BETH A (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Age;Age Months;Age of Onset;arm;arm movement;Behavior;Bilateral;Biomedical Engineering;Biometry;Brain;Caregivers;Cerebral Palsy;Characteristics;Classification;Code;Cognitive;cognitive development;Data;Data Analyses;Data Sources;design;Development;Developmental Disabilities;Early Intervention;Eating;Education;Electroencephalography;Eligibility Determination;Environmental Risk Factor;experience;Goals;high risk;Home;Impairment;improved;Individual;infancy;Infant;Infant Development;Intervention;intervention program;Learning;Learning Skill;limb movement;Link;Longitudinal Studies;Measures;Methods;Motor;motor behavior;motor control;motor learning;Motor Skills;Movement;neural;Nursery Schools;nutrition;Outcome;Parents;Parietal;Pattern;Pediatric Neurology;Pediatrics;Perception;Population;Predictive Factor;preference;Process;Research;Rest;Risk;School-Age Population;skill acquisition;skills;Sleep;Source;source localization;theories;Therapeutic Intervention;Work

PROJECT_TITLE: Emergence of arm reaching behavior and lateralization of motor control in infancy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital with the objective to establish and build a comprehensive and sustainable resource to support the growth of pediatric sleep, circadian rhythms, and mental health research while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The proposed COBRE Center will be the first and only NIH-funded research center in the country to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. Extending the reach and accelerating the growth of a cadre of clinical scientists with multidisciplinary training and with the infrastructure to support advancement to independent research careers shows great promise to improve the health and well-being of children and adolescents and their families.

PI_NAMEs: CARSKADON, MARY A (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 17q12;Acceleration;Adolescence;Adolescent;adolescent mental health;Adolescent Psychiatry;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;career;Career Mobility;Centers of Research Excellence;Characteristics;Child;Child Mental Health;Child Psychiatry;Child Welfare;Childhood;Chronobiology;circadian;circadian pacemaker;Circadian Rhythms;Clinical;clinical care;Cognitive;Collection;Complex;Computer software;Consultations;Copy Number Polymorphism;Core Facility;Country;Data;Databases;design;Development;Diagnostic;DNA copy number;Doctor of Philosophy;Drowsiness;DSM-V;Early Intervention;Epidemiologist;Evaluation;Faculty;Family;Feeling suicidal;Functional Magnetic Resonance Imaging;Funding;Genes;Goals;Green space;Growth;Health;health assessment;Heart;Home;Hospitals;Impaired cognition;improved;Incidence;Infrastructure;Institution;instrumentation;knowledge base;Laboratories;Leadership;life span;Link;Maintenance;Measures;Memory;Mental disorders;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Nature;neuropsychiatric disorder;neuropsychiatry;neuropsychopharmacology;Occupational activity of managing finances;Participant;Pathway interactions;Phenotype;Pilot Projects;preventive intervention;programs;Psychiatrist;psychobiology;Psychologist;recruit;Research;Research Methodology;Research Personnel;Resources;Rhode Island;rumination;Schizophrenia;Schools;Science;Scientist;Self Assessment;Sleep;sleep behavior;Sleep disturbances;sleep health;sleep pattern;social;Structure;suicidal act;suicidal risk;sustainable resource;Technology;theories;therapeutic target;Training;United States National Institutes of Health;Vulnerable Populations;Work;Youth

PROJECT_TITLE: COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences;Pediatric;Sleep Research

PROJECT_TERMS: Adolescent;adolescent mental health;Advisory Committees;apprenticeship;Behavioral;Biomedical Research;career;Centers of Research Excellence;Child;Child health care;Childhood;circadian;Circadian Rhythms;Clinical;Clinical Services;Collaborations;Consultations;diversity and inclusion;Educational workshop;Effectiveness;Environment;Evaluation;Event;Family;field study;Funding;Goals;Growth;Health;Heart;Hospitals;Leadership;lens;life span;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Mission;Neurodevelopmental Disorder;Participant;Personal Satisfaction;Persons;Pilot Projects;Process;programs;Psychiatric Hospitals;psychobiology;Research;Research Personnel;Role;Running;Science;Scientist;Series;Sleep;Sleep disturbances;Structure;success;sustainable resource;symposium;Training;Training Activity;Training Programs;Travel;United States;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In this proposal the PI will study patients with Idiopathic Hypogonadotropic Hypogonadism (IHH), an inherited disease of delayed puberty and infertility for which the genetic etiology remains to be fully characterized. In this training grant the PI will define the role of copy number variants (variants that lead to loss or gain of genetic material) in IHH and will be trained in human genetics and clinical investigation. Successful execution of this proposal will fill critical gaps in our understanding of the genetic control of human reproduction and will enable the PI to develop into an independent investigator.

PI_NAMEs: STAMOU, MARIA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Age;Algorithms;Amenorrhea;Architecture;Area;Award;Base Pairing;biobank;Biological Factors;Biology;Cardiovascular system;career;Cells;Center for Translational Science Activities;Centers for Disease Control and Prevention (U.S.);Chronic;clinical investigation;Clinical Investigator;Code;cohort;Complex;Copy Number Polymorphism;Data;Databases;Defect;defined contribution;Delayed Puberty;Detection;Diabetes Mellitus;Diagnostic;Disease;Enrollment;Environment;Exhibits;exome sequencing;Fellowship;Fertility;gene discovery;General Hospitals;Genes;Genetic;genetic architecture;Genetic Materials;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genomic DNA;Genomic medicine;Genomics;Genotype;Goals;Gonadotropin Hormone Releasing Hormone;Grant;Health;Hereditary Disease;Heritability;Heterozygote;Hospitals;Hot flushes;Human;human disease;Human Genetics;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;improved;Incidence;Individual;induced pluripotent stem cell;Infertility;Inherited;insight;Investigation;K-Series Research Career Programs;Link;Malignant - descriptor;Massachusetts;meetings;men;Mendelian disorder;Menopause;Mentors;Mentorship;Molecular;Names;National Institute of Child Health and Human Development;Neurons;Neuropeptides;Neurosecretory Systems;neurotransmission;new therapeutic target;next generation sequencing;novel;Obesity;Pathogenesis;Pathway interactions;Patients;phenome;phenomics;Phenotype;Physicians;Polycystic Ovary Syndrome;Population;Population Genetics;Precocious Puberty;Predisposition;Prevalence;Proteins;rare genetic disorder;rare mendelian disorder;Reproduction;reproductive;Reproductive Biology;Reproductive Endocrinology;Reproductive Medicine;reproductive system disorder;Research;Research Personnel;Research Proposals;Resources;Role;Scientist;Single Nucleotide Polymorphism;skill acquisition;study population;Technology;tool;Training;translational impact;Untranslated RNA;Validation;Variant;Woman;Work

PROJECT_TITLE: Deciphering the Role of Copy Number Variants in Neuroendocrine Disorders of Infertility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: Atlanta

ORG_NAME: GEORGIA STATE DEPARTMENTOF PUBLIC HEALTH

PHR: Project Narrative The Georgia Pregnancy Risk Assessment Monitoring System (PRAMS) Project will continue to collect population-based data on women’s attitudes, experiences, and behaviors before, during, and shortly after delivering a live birth in Georgia. Mothers will be contacted by mail, phone and web (when it becomes available). The information gained from this surveillance system will be used to identify risk factors and disparities in adverse birth outcomes, determine maternal and child health priorities, develop and evaluate programmatic interventions, and inform policies that will improve the health of mothers and infants in Georgia.

PI_NAMEs: JOHNSTON, SABRINA  (contact)

PROJECT_TITLE: RFA-DP-21-001 Georgia Pregnancy Risk Assessment Monitoring System (PRAMS) Project


ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE OFFICE OF PUBLIC HEALTH

PHR: CDC-RFA-DP-21-001 Louisiana PRAMS Application Project Narrative:  Louisiana Pregnancy Risk Assessment Monitoring System (PRAMS) is an ongoing, population-based risk factor surveillance system designed to describe maternal behaviors and experiences that occur before, during, and immediately following pregnancy. The program is administered by the Louisiana Department of Health, Bureau of Family Health in conjunction with the Centers for Disease Control and Prevention (CDC). Information collected by Louisiana PRAMS is used by health professionals, policy makers, and researchers to develop and modify programs and policies designed to improve the health of mothers and infants. Louisiana PRAMS provides both quantitative and qualitative data on:   Factors that influence pregnancy outcomes, including health insurance status, chronic  conditions, pregnancy intention, contraceptive use, prenatal care, alcohol use, tobacco  use, physical abuse, and life stress   Mothers’ experience of pregnancy complications, including hypertension, diabetes and hospitalizations   Maternal experiences and behaviors after the baby is born, including depression,  maternity leave experiences, breastfeeding, contraceptive use, tobacco and alcohol use,  and safe infant sleep practices 1

PI_NAMEs: PIERCE, DIONKA  (contact)

PROJECT_TITLE: DP21-001 Louisiana Pregnancy Risk Assessment Monitoring System Application


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: PROJECT NARRATIVE Molecular linkers of the nucleus to the cytoskeleton transmit forces between the cell microenvironment and the genome. They are frequently mutated or dysregulated in cancer, and some of these changes have been proposed to be cancer drivers through unknown mechanisms. Here a multidisciplinary team will combine molecular biology, cell biology, and physical-science based approaches to address this fundamental question.

PI_NAMEs: LELE, TANMAY P. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Binding;Biology;Breast Cancer Cell;breast cancer progression;Cancer Biology;cancer cell;cancer invasiveness;Carcinoma;cell behavior;cell motility;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Choristoma;Chromatin;Complex;Computer Models;Coupled;Cytoskeletal Modeling;Cytoskeleton;Data;Data Set;Development;driver mutation;Engineering;env Gene Products;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Functional disorder;Gene Abnormality;Gene Expression;Generations;Genes;Genome;genome-wide;Heterochromatin;insight;Knowledge;Learning;Left;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Measures;mechanical force;Mechanical Stress;Mechanics;member;Membrane;migration;Molecular;Molecular Biology;multidisciplinary;Mutate;Mutation;Normal Cell;novel strategies;Nuclear;Nuclear Envelope;Nuclear Lamina;Nuclear Structure;Pathogenesis;Phenotype;physical science;Positioning Attribute;protein complex;Proteins;response;Role;sensor;Stress;Structure;System;transmission process;virtual

PROJECT_TITLE: Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmittedby the LINC Complex


ORG_CITY: BALTIMORE

ORG_NAME: MARYLAND STATE DEPARTMENT OF HEALTH

ORG_STATE: MD

PHR: Project Narrative The Pregnancy Risk Assessment Monitoring System or PRAMS is a Centers for Disease Control and Prevention (CDC) supported surveillance initiative that works with state health departments to collect state-specific, population-based data on maternal attitudes and experiences before, during, and shortly after pregnancy. This population-based data provides a rich source of information, some not otherwise available, for maternal and child health programs and policy.

PI_NAMEs: CHOO, SHELLY  (contact)

PROJECT_TITLE: DP-21-001 Maryland Pregnancy Risk Assessment Monitoring System (PRAMS)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Sleep Research

PI_NAMEs: WOLFF, JENNIFER CHRISTINE (contact)

PROJECT_TERMS: Achievement;Address;Adolescent;adolescent mental health;advanced system;Area;Articulation;Behavioral;biobank;Biological Markers;Blood specimen;Catalogs;Centers of Research Excellence;central database;Child;Child Care;Child Mental Health;Childhood;Circadian Rhythms;clinical care;Clinical Research;cognitive testing;Collection;Computers;Concept Formation;Consultations;Data;Data Analyses;Data Collection;data harmonization;data integration;data management;data repository;data resource;data streams;Databases;design;Development;Educational workshop;electronic medical record system;eligible participant;Emergency medical service;Emerging Technologies;Ensure;epigenetic variation;Ethics;evidence base;experience;Family;Genetic Variation;Goals;Guidelines;Harvest;health assessment;Health Insurance Portability and Accountability Act;Hormones;Hospitals;Immunologic Markers;informant;Infrastructure;innovation;Knowledge;Laboratories;Libraries;Licensing;Link;Measurement;Measures;Medical Records;Mental disorders;Mental Health;Mentors;Methods;microbiome;mobile application;Monitor;multidisciplinary;multimodality;National Institute of Mental Health;open data;Participant;Patient Self-Report;Pediatric Research;Practice based research;Practice Guidelines;Procedures;Process;programs;Protocols documentation;psychobiology;psychologic;Publications;Reporting;repository;Reproducibility;Research;Research Domain Criteria;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Resources;Rhode Island;saliva sample;Sampling;Science;secondary analysis;Secure;service providers;Services;Shipping;Sleep;sleep health;Spanish/English;stool sample;sustainable resource;Symptoms;System;Techniques;Technology;Training;Trust;United States National Institutes of Health;Update;Vendor;web app;Work

PROJECT_TITLE: Pediatric Biopsychology Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Kidney Disease;Lung;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ADDIS ABABA

ORG_COUNTRY: ETHIOPIA

ORG_FIPS: ET

ORG_NAME: ADDIS ABABA UNIVERSITY

PHR: PROJECT NARRATIVE The primary focus of the proposed research is air pollution, with sub-studies focused on exposure assessment and air pollution impacts on lung function, blood pressure, and cognitive development, as well as a study focused on occupational heat stress. The research will take place at three leading universities in East Africa: Addis Ababa University in Addis Ababa, Ethiopia; Makerere University in Kampala, Uganda, and University of Nairobi in Nairobi, Kenya. The portfolio of studies in the proposed research solidifies and expands work begun in the first funding cycle of the Eastern Africa GEOHealth Hub, and will provide excellent opportunities for the trainees at each institution, as described in the linked GEOHealth Research Training proposal.

PI_NAMEs: BERHANE, KIROS T;JACK, DARBY ;KUMIE, ABERA TAKELE (contact);SIMANE, BELAY

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Accounting;Address;adverse outcome;Africa;African;air monitoring;Air Pollution;air pollution control;ambient air pollution;Awareness;Blood Pressure;burden of illness;Capital;Cessation of life;Child;Child Health;Chronic Kidney Failure;Cities;climate change;cognitive development;cohort;Collaborations;Collection;Country;Data;Data Collection;development policy;disorder risk;Eastern Africa;Environment;Environmental Health;Environmental Illness;Environmental Monitoring;Environmental Policy;Epidemiology;epidemiology study;Ethiopia;evidence base;Exposure to;extreme heat;Face;fine particles;Foundations;Funding;global environment;Goals;Health;Heat Stress;Hospital Mortality;Household;Income;Inequity;Infrastructure;Injury;Institution;interest;Investments;Kenya;Link;low and middle-income countries;low income country;lung development;Measures;Mentors;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;Needs Assessment;Neurocognitive;Occupational;Occupational Exposure;Occupational Health;Pilot Projects;Policies;Population Characteristics;premature;Productivity;programs;Psychometrics;Public Health;pulmonary function;Records;Renal function;Reproductive Health;Request for Applications;Research;Research Design;Research Personnel;Research Training;Resolution;respiratory health;Respiratory Signs and Symptoms;response;Risk;Risk Factors;Sampling Studies;Series;Shapes;Site;Source;spatiotemporal;Structure;success;Testing;Time;Training;Training Programs;Translations;Uganda;Universities;Woman;women's reproductive health;Work;Workplace

PROJECT_TITLE: Global Environmental and Occupational Health Research and Training for Eastern Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Novel strategies aimed at reinvigorating anti-tumor immune responses have shown promise for the treatment of cancer, but the majority of patients have only minimal or transient responses to these treatments. We have hypothesized that aberrant T-cell metabolism limits anti-tumor T-cell responses and have identified redox imbalance as a critical regulator of T-cell immunity in experimental systems as well as in primary patient samples. The proposed research will test the importance of oxidative stress as a driver of intratumoral T-cell dysfunction and determine whether metabolically rewiring T-cells to enhance redox homeostasis represents a broadly applicable strategy for improving immune responses in cancer.

PI_NAMEs: VARDHANA, SANTOSHA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acetylcysteine;Affect;Amino Acids;anti-PD1 therapy;anti-tumor immune response;Antigens;Antioxidants;Bioenergetics;Biological Markers;Biological Models;Biological Response Modifiers;Biopsy;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer infiltrating T cells;cancer subtypes;cancer therapy;career;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Characteristics;chromatin modification;chromatin remodeling;Chronic;Citric Acid Cycle;clinical training;Cysteine;cytotoxic;Data;Defect;demethylation;DNA;effector T cell;engineered T cells;Environment;Epigenetic Process;Excretory function;exhaustion;experience;Exposure to;Face;Failure;Functional disorder;Funding;Gene Expression;Generations;Genetic;Glucose;Glutamine;Glutathione;Half-Life;Histones;Homeostasis;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immune Targeting;Immunity;Immunology;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;in vivo;in vivo Model;Institution;International;Investigation;Laboratories;Lymphoma;Malignant Neoplasms;MAP2K1 gene;Measures;Medical Oncology;MEKs;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Metabolism;Methyltransferase;Minority;mouse model;Mus;Non-Essential Amino Acid;novel;novel strategies;Nucleotide Biosynthesis;nucleotide metabolism;Nutrient;Nutrient availability;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patients;pharmacologic;Physicians;Positioning Attribute;programs;Proliferating;Reaction;Reactive Oxygen Species;Research;Research Personnel;response;Sampling;Scientist;Services;Signal Transduction;Stress;synergism;System;T cell response;T cell therapy;T-Cell Proliferation;T-Lymphocyte;Testing;Training;treatment response;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;uptake;Waste Products

PROJECT_TITLE: Investigating altered T-cell metabolism during chronic antigen encounter

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research

PI_NAMEs: BARKER, DAVID HEATON (contact)

PROJECT_TERMS: actigraphy;Address;adolescent mental health;apprenticeship;Beds;Calibration;Centers of Research Excellence;Child;Child Mental Health;Childhood;circadian;Circadian Rhythms;complex data;Computer software;computerized data processing;Consultations;contextual factors;Data;data acquisition;data quality;Data Storage and Retrieval;Databases;Development;diaries;Drowsiness;Goals;Grant;Health Insurance Portability and Accountability Act;Hospitals;human subject;Infrastructure;innovation;Institutional Review Boards;Instruction;instrument;instrumentation;interest;International;Laboratories;Language;Libraries;Light;Lighting;Measurement;Measures;Mental Health;Methodology;Methods;Monitor;multidisciplinary;multimodality;novel;Phase;Physiology;Polysomnography;population health;pressure;Process;programs;Protocols documentation;quality assurance;Quality Control;Recommendation;Recording of previous events;Research;Research Design;Research Personnel;Research Support;Resources;Science;Services;Sleep;sleep behavior;sleep regulation;social;Staging;Structure;Surveys;syntax;theories;time use;Training;training opportunity;Training Programs;Visual;wearable device;working group

PROJECT_TITLE: Sleep and Circadian Methods (SCM) Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Natural Products

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Chronic low-grade inflammation, a hallmark of advancing age termed inflammaging, has been implicated in metabolic dysfunction. Increased senescent burden in both solid organs (i.e.; liver, adipose tissue) and immune cells, also known as immunosenescence, likely contribute to inflammaging, but the interplay between the two, the mechanisms governing these processes and how they lead to metabolic dysfunction are poorly understood. Here, we seek to elucidate whether cellular senescence per se, immune cell recruitment/accumulation and the associated tissue inflammation, or both underlie age-related metabolic dysfunction.

PI_NAMEs: LESNIEWSKI, LISA A (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Adaptive Immune System;Adipocytes;Adipose tissue;Age;age effect;age related;age related changes;age-related disease;Aging;Antibodies;Cell Aging;Cell Cycle Arrest;cell injury;Cells;chemokine;Chronic;cytokine;Dasatinib;Data;DNA Damage;Elderly;Functional disorder;Glucose Intolerance;Hepatocyte;Homeostasis;Immune;immunosenescence;Impairment;improved;Inflammaging;Inflammation;Inflammation Mediators;Injections;Insulin Resistance;lipid metabolism;Liver;LoxP-flanked allele;Macrophage;Mature T-Lymphocyte;Mediating;Metabolic;Metabolic dysfunction;Metabolism;middle age;Modeling;Mus;novel;old mice;Organ;Outcome;Oxidative Stress;Pharmaceutical Preparations;Phenotype;Process;Proteins;Quercetin;recruit;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Solid;stressor;systemic inflammatory response;T cell therapy;T-Cell Depletion;T-Lymphocyte;Tamoxifen;telomere;Tissues;Toxin;Visceral

PROJECT_TITLE: Tissue senescence and age-associated metabolic dysfunction: the role of immune cell mediated inflammation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Violence Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE The high prevalence of violence (i.e. intimate partner violence, child abuse, community violence) experienced by people living with HIV (PLWH) and its negative impact on HIV-related health outcomes underscore the need for systematic violence screening and intervention to be incorporated into HIV care services. To help resource- limited Ryan White HIV Clinics (RWCs) and AIDS Service Organizations (ASOs) at the heart of the United States HIV epidemic prioritize the forms of violence on which they should dedicate screening and support services, we first assess the relative impact of the different forms of violence on retention in HIV care and HIV viral suppression. Next, we explore the preferences of key stakeholders (i.e. PLWH, HIV care providers and staff at RWCs and ASOs) for violence screening and support service provision/referral to ultimately inform evidence- based violence screening protocols and a proof-of-concept violence support model that leverages existing local RWC and ASO infrastructure to address psychosocial consequences of violence.

PI_NAMEs: KALOKHE, AMEETA SHIVDAS;SALES, JESSICA A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Administrator;Adopted;Adoption;Advocacy;assault;Awareness;Blood;care outcomes;care providers;care systems;Caring;Categories;Cessation of life;Child;Child Abuse;cis-female;Clinic;Clinical;clinically relevant;Communities;community partners;community violence;Conservatism;Continuity of Patient Care;Counseling;Data;Dedications;Development;Dimensions;Eligibility Determination;Ensure;Epidemic;evidence base;experience;Funding;Future;Gender;hate crimes;Health;Heart;High Prevalence;HIV;HIV Infections;Homophobia;implementation science;Individual;informant;Infrastructure;innovation;insight;Interpersonal Violence;Intervention;Interview;intimate partner violence;Legal;Link;Measurement;Medical;men;Mental Health;Methods;Modeling;Outcome;Participant;Patient Preferences;Patients;Persons;Pharmacotherapy;Phase;Poverty;preference;primary care setting;Process;programs;Provider;psychosocial;racism;Recording of previous events;Research;Resources;response;Sampling;screening;service organization;Service provision;Services;sex;Sexual abuse;Shelter facility;Site;social;social determinants;Southeastern United States;Structure;Surveys;Survivors;System;Time;transgender;transphobia;Trauma;Treatment/Psychosocial Effects;United States;Violence;violent crime;Viral;Viral Load result;Visit;Woman;Work

PROJECT_TITLE: An implementation science study of violence screening practices among Ryan White-funded sites in the Southeastern United States


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This proposal will identify the circuit mechanisms that coordinate learning across networks of neurons, filling a critical gap in our understanding how future behavior is guided by past outcomes. These mechanisms may be relevant for addressing numerous cognitive disorders by identifying targets for highly selective intervention to adjust learning in brain networks.

PI_NAMEs: KERLIN, AARON MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Action Potentials;Address;Anatomy;Apical;Area;Behavior;behavior change;Behavior Control;Behavioral;behavioral outcome;Biological Models;Biological Neural Networks;Brain;Calcium;Calcium Spikes;Cells;Code;Cognition Disorders;Complex;Computer Models;Custom;Data;Dendrites;Elements;Event;experience;experimental study;Feedback;frontal lobe;Future;Generations;Glutamates;Image;improved;in vivo;Individual;inhibitory neuron;insight;Intervention;Knowledge;Laboratories;Learning;Learning Skill;Machine Learning;machine learning algorithm;Maps;Measures;Microscope;Modeling;Modification;Monitor;Motor;Motor Cortex;multi-photon;Mus;Nervous System;Neurons;novel;Optics;optogenetics;Outcome;Output;Performance;Phase;Play;Population;Positioning Attribute;Process;Publishing;Recurrence;response;Role;segregation;Sensory;sensory cortex;sensory feedback;Short-Term Memory;signal processing;Signal Transduction;Source;Synapses;Techniques;Testing;Thalamic structure;theories;transmission process;two-photon;Weight;Work

PROJECT_TITLE: A dendritic nexus in the circuits that coordinate learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Prevention;Skin Cancer

ORG_CITY: BIRMINGHAM

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE. Preventive options to combat non-melanoma skin cancer (NMSC) are very limited. The new rexinoids developed here will be nontoxic and highly effective in preventing NMSC. These agents will have strong potential to translate into potent clinical candidates for prospective trials against NMSC.

PI_NAMEs: ATIGADDA, VENKATRAM REDDY (contact)

PROGRAM_OFFICER_NAME: MALONE, WINFRED F

PROJECT_TERMS: Acidity;Adverse effects;Agonist;alitretinoin;American Cancer Society;analog;Animals;Apoptosis;Basal cell carcinoma;Bexarotene;Binding;Biological Availability;Biological Markers;biophysical analysis;Calorimetry;Cancer Biology;cancer chemoprevention;cancer diagnosis;Cancer Model;cancer type;Carbon;Carboxylic Acids;Cause of Death;Cell Respiration;Chemopreventive Agent;Chronic;Clinical;clinical candidate;clinical development;combat;Complex;Cutaneous Lymphoproliferative Disorder;Data;design;Development;Disease;Dose;Drug Kinetics;Economic Burden;Emotional;Evaluation;experimental study;FDA approved;Fluorine;Genetic Transcription;Grant;Half-Life;Halogens;high risk;Homo;Human;human model;Hydrogen;Hyperlipidemia;Immune;Immunity;improved;In Vitro;Individual;Inflammation;Inflammatory;innovation;Investigation;Isotretinoin;Laboratories;Ligand Binding;Lipids;lipophilicity;Liver X Receptor;Malignant Epithelial Cell;Malignant Neoplasms;Measures;member;Metabolic;metabolic profile;Modeling;Modification;Molecular Conformation;mouse model;Nitrogen;non-compliance;novel;Nuclear Receptors;Oral;organ transplant recipient;Parents;Peptides;Pharmaceutical Preparations;pharmacologic;phase 1 study;Play;Polyenes;Population;pre-clinical;preclinical development;preclinical evaluation;prevent;Prevention;Prevention strategy;Preventive;Proliferating;Property;prospective;Proteins;receptor;recruit;Research Personnel;Retinoic Acid Receptor;Retinoids;Roentgen Rays;Role;RXR;Safety;Serum;side effect;Skin;skin cancer prevention;Skin Carcinogenesis;Skin Carcinoma;skin lesion;small molecule;Solid;Squamous cell carcinoma;Structure;Surface;Tetralones;time interval;tissue biomarkers;Titrations;Toxic effect;Translating;Translations;Tretinoin;UVB induced;water solubility;X-Ray Crystallography

PROJECT_TITLE: Development of Potent and non-toxic rexinoids to prevent non-melanoma skin cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative  HSE is a life-threatening viral infection of the CNS. In some children, forebrain HSE is caused by inborn errors of TLR3-, IFN-a/b or -l-mediated CNS-intrinsic immunity, whereas in others, brainstem HSE is caused by inborn errors of DBR1-dependent RNA lariat metabolism, which probably disrupts CNS-intrinsic immunity by TLR3- and IFN-independent mechanisms. We aim to study the CNS-, tissue-, and cell-intrinsic basis of forebrain and brainstem HSE in two complementary ways: (i) we will analyze TLR3, IFN responses and HSV-1 infection in iPSC-derived olfactory and cortical neurons, and other CNS cells including microglial cells, from patients carrying known and novel genetic etiologies of forebrain HSE, (ii) we will analyze lariat accumulation and HSV-1 infection in TG and brainstem neurons derived from DBR1-deficient patient iPSCs. These studies should enable us to analyze in greater depth and breadth the cellular basis of human CNS- intrinsic immunity to HSV-1 and the pathogenesis of HSE.

PI_NAMEs: CASANOVA, JEAN-LAURENT  (contact);ZHANG, SHEN-YING

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;Agonist;astrocyte progenitor;Astrocytes;Benign;Biological;Brain Stem;Cell Line;Cells;Central Nervous System;Central Nervous System Viral Diseases;Child;Childhood;Clinical;Coculture Techniques;Complication;Country;CRISPR/Cas technology;Data;Defect;Development;disease model;Dissection;Encephalitis;Fibroblasts;Generations;Genes;Genetic;Genetic Predisposition to Disease;Hereditary Disease;Herpes encephalitis;Herpes Simplex Infections;Herpesvirus 1;Human;human induced pluripotent stem cells;IFNAR1 gene;Immune response;Immunity;Immunology;Impairment;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Infection;Infectious Agent;innovation;Interdisciplinary Study;Interferon alpha;Interferon Type II;Interferon-beta;Interferons;IRF3 gene;Knock-in;knockout gene;Lesion;Leukocytes;Life;Mediating;Messenger RNA;Metabolism;Microglia;Molecular;mRNA Precursor;Mutate;Mutation;nerve stem cell;Neurology;Neurons;novel;olfactory bulb;olfactory sensory neurons;oligodendrocyte progenitor;Oligodendroglia;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pediatrics;Peripheral Nervous System;pluripotent stem cell differentiation;Primary Infection;Probability;Production;programs;Prosencephalon;Protocols documentation;Recombinants;response;RIPK1 gene;RIPK3 gene;RNA;RNA Splicing;Role;Signal Transduction;STAT1 gene;stem cell biology;Structure of trigeminal ganglion;System;TBK1 gene;Testing;Tissues;TLR3 gene;TNF receptor-associated factor 3;Trigeminal nerve structure;Trigeminal System;United States National Institutes of Health;Viral Encephalitis;virology

PROJECT_TITLE: Molecular and Cellular Dissection of the Pathogenesis of Herpes Simplex Encephalitis with iPSC-Derived CNS and PNS Cells


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Nutrition;Substance Misuse

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research will contribute to the fundamental knowledge of how neural circuits can undergo modulation to drive adaptive behavioral responses to account for changes in their external environment. My work focuses on how these shifts in neuromodulation can affect memory processing circuits and lead to changes in the acquisition and retrieval of memories. This becomes particularly important when it comes to drugs of abuse, specifically alcohol, and my work will highlight mechanisms by which an animal’s internal state can affect memory processing for drugs of abuse.

PI_NAMEs: NUNEZ, KAVIN MILCIADES (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: addiction;Affect;alcohol memory;alcohol response;Alcoholic Intoxication;Alcohols;analytical method;Animals;Arousal;Award;Behavior;Behavioral;behavioral response;Calcium;career;conditioning;Confocal Microscopy;craving;Cues;Data Analyses;Data Set;Development;Disease;Dose;Drosophila genus;Drosophila melanogaster;Drug abuse;drug of abuse;Ensure;Environment;experimental study;Fellowship;fly;Food deprivation (experimental);Genetic;Grant;Image;Imaging Techniques;Immunohistochemistry;in vivo calcium imaging;Institution;interest;Intoxication;Invertebrates;Knowledge;large scale data;large-scale imaging data;Mediating;Memory;memory acquisition;memory process;memory retrieval;Methods;Monitor;Moods;multisensory;Mushroom Bodies;neural;neural circuit;Neurons;neuroregulation;Neurosciences;neurotransmission;Norepinephrine;Nutritional;Octopamine;Odors;Olfactory Pathways;olfactory stimulus;Output;Phase;Physiological;Postdoctoral Fellow;postsynaptic;preference;Process;Relapse;Research;Research Personnel;Research Project Grants;Resources;response;Retrieval;reward circuitry;Rewards;Satiation;Sensory;sensory integration;signal processing;skill acquisition;skills;Stains;Stimulus;Stress;Synapses;System;Testing;Training;visual stimulus;Visualization;Work;Writing

PROJECT_TITLE: Integration of Olfactory and Visual Stimuli for Navigation in Drosophila


ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE The mitochondrial metabolic enzyme glutaminase (GLS) has been implicated in diverse pathological conditions ranging from neurodegeneration to cancer, and an allosteric GLS inhibitor is currently being evaluated in several clinical trials. The studies proposed here are aimed at defining the molecular mechanisms underlying a new regulatory process we have identified, whereby the bioactive phospholipid phosphatidic acid (PA) binds and potently activates GLS even in the presence of clinical GLS inhibitors, thus rendering these drugs ineffective. Knowledge gained from this project will shed new light on the physiological regulation of glutamine metabolism, and will determine whether suppression of mitochondrial PA signaling can overcome the problem of resistance to GLS-targeted therapies.

PI_NAMEs: LUKEY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acids;alpha ketoglutarate;Amino Acids;Aminobutyric Acids;Ammonium;Anabolism;Antioxidants;Arginine;base;Binding;Binding Proteins;Binding Sites;Biological Process;biophysical properties;Brain;Carbon;Cells;Charge;Chemicals;Chemistry;Clinical;Clinical Treatment;Clinical Trials;Collaborations;Data;deamidation;Diglycerides;DNA;Endowment;enzyme activity;Enzymes;Epigenetic Process;excitotoxicity;Family member;Fatty Acids;Gastrointestinal tract structure;Genes;Genetic;GLS2 gene;Glutamates;Glutaminase;Glutamine;Glutathione;Glycerol;Glycerophospholipids;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Head;Health;Hematologic Neoplasms;Histones;Homeostasis;Human;Human Pathology;Hydrolysis;In Vitro;in vitro activity;Inborn Errors of Metabolism;inhibitor;Inner mitochondrial membrane;inorganic phosphate;Kidney;Knowledge;Laboratories;Lecithin;Length;Lipids;Liver;Lysine;lysophosphatidic acid;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Membrane;Metabolic;Metabolism;Metabolite Interaction;Mitochondria;Molecular;Mutation;Nature;neonatal encephalopathy;Nerve Degeneration;neural;Neurotransmitters;Nitrogen;Nutrient;Pathologic;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphatidic Acid;Phospholipase;Phospholipase D;phospholipase D2;Phospholipids;phosphomonoester;Phosphoric Monoester Hydrolases;Phosphorus;Phosphotransferases;Physiological;Physiological Processes;Physiology;Plasma;Process;Proteins;Reaction;Recombinants;Recording of previous events;Regulation;Reporting;Research;Resistance;Resistance development;resistance mechanism;Role;Shapes;Signal Transduction;Site;Solid;Source;Specificity;Structure-Activity Relationship;Tail;targeted treatment;Testing;tool;Treatment Efficacy;unsaturated bonds;Vertebral column

PROJECT_TITLE: Defining the role of phosphatidic acid as an allosteric regulator of mitochondrial glutaminase

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: Rochester

ORG_NAME: EMMYON, INC.

PHR: PROJECT NARRATIVE In patients who suffer from cancer, muscle wasting is very common and has devastating consequences, including reduced quality of life and overall health, interference with cancer treatment, increased complications from cancer treatment, and reduced survival. Unfortunately, right now, we do not have any medicines to help prevent or treat muscle wasting in patients suffering from cancer. To help address this issue, we propose a Phase II SBIR study to investigate and develop new and promising potential medicines for cancer-induced muscle wasting.

PI_NAMEs: ADAMS, CHRISTOPHER M;EBERT, SCOTT MATTHEW (contact);JUDGE, ANDREW ROBERT;JUDGE, SARAH M;TALLEY, JOHN JEFFREY

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acids;Address;Advanced Development;Advanced Malignant Neoplasm;Adverse effects;Affect;Age;Animals;Apple;Atrophic;C26 tumor;Cancer Cachexia;cancer complication;Cancer Model;Cancer Patient;cancer therapy;carcinogenesis;Cell model;Chemicals;Chemistry;Clinical;clinical development;Clinical Research;commercialization;Cultured Cells;design;Development;Dose;FDA approved;Fruit;Goals;Health;Herb;Human;improved;in vivo;innovation;KPC model;Lead;Legal patent;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medicine;mortality;mouse model;mRNA Expression;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;Natural Compound;novel;novel therapeutics;Oral;Outcome;pancreatic cancer model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Physical Function;Physiological;Pre-Clinical Model;prevent;programs;Property;Quality of life;response;Safety;Scientific Advances and Accomplishments;Series;sex;Skeletal Muscle;skeletal muscle wasting;Small Business Innovation Research Grant;Structure-Activity Relationship;success;Syndrome;Testing;Tissues;tumor;tumor growth;ursolic acid;Work

PROJECT_TITLE: Development of novel therapeutics for cancer cachexia


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative This is a multidisciplinary, highly collaborative proposal that combines next-generation sequencing with state- of-the-art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this proposal are to identify gene variants that are associated with compulsive alcohol use, alcohol tolerance and response to FDA approved medications using genome-wide association studies (GWAS) in behaviorally characterized heterogeneous stock rats, and to establish a data/tissue repository accessible to all researchers to study the cellular and molecular mechanisms of alcohol addiction. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of compulsive alcohol use in males and females, and create a unique data/tissue repository that will facilitate follow-up and replication studies.

PI_NAMEs: DE GUGLIELMO, GIORDANO  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;addiction;Adrenal Glands;Alcohol abuse;alcohol abuse therapy;alcohol availability;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Anatomy;Animal Model;animal tissue;Animals;Basic Science;Behavior;Behavioral;biobank;Biochemical;Biological;Blood;Blood specimen;Brain;Cell Culture Techniques;Cells;Cessation of life;Chronic;Communities;cost;Cryopreservation;Data;Data Set;Development;drinking;Environment;Epigenetic Process;Family Study;FDA approved;Female;follow-up;Follow-Up Studies;Freezing;Funding;Gene Expression;Generations;Genes;Genetic;Genetic Recombination;Genetic study;genetic variant;genome wide association study;Genotype;Goals;Haplotypes;Heritability;Histocompatibility;Human Genome;Hyperalgesia;Inbred Strains Rats;Individual;Individual Differences;induced pluripotent stem cell;Infrastructure;interdisciplinary approach;Kidney;Liver;longitudinal analysis;male;Maps;Measures;Mental disorders;Methods;Modeling;Molecular;multidisciplinary;Mus;National Institute of Drug Abuse;Neuroanatomy;neurobiological mechanism;new therapeutic target;next generation sequencing;novel;Ovary;Perfusion;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenotype;preclinical trial;premature;Protocols documentation;Quantitative Reverse Transcriptase PCR;Quinine;Rattus;Relapse;Research Personnel;research study;Resolution;Resources;response;Sampling;screening;screening program;Self Administration;Spleen;Standardization;standardize measure;Substance abuse problem;Substance Addiction;Technology;Testing;Testis;Tissue Banks;Tissue Preservation;Tissue Sample;Tissues;trait;Translational Research;Twin Studies;United States National Institutes of Health;vapor;Variant;Western Blotting;Withdrawal

PROJECT_TITLE: Identification of Genetic Variants that Influence Compulsive Alcohol Intake in Outbred Rats

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Sleep Research

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

PI_NAMEs: RIGHI, GIULIA  (contact)

PROJECT_TERMS: actigraphy;Address;Adolescent;adolescent mental health;Age;Anxiety;anxiety treatment;Behavior Therapy;Centers of Research Excellence;Child;childhood anxiety;Circadian Rhythms;Clinical;Cognitive Therapy;Computers;Disease remission;Electroencephalography;Extinction;Fright;Galvanic Skin Response;Impairment;improved;indexing;innovation;Knowledge;Learning;learning extinction;Link;Measurement;Measures;Methodology;Methods;novel;Obsessive-Compulsive Disorder;Outcome;outpatient programs;Patient Self-Report;Psychophysiology;Reporting;Research;response;Role;Sampling;Sleep;Sleep Disorders;Sleep disturbances;sleep quantity;Symptoms;Testing;Therapeutic;Time;Work;Youth

PROJECT_TITLE: Sleep and Fear Extinction Learning among Adolescents with Anxiety or OCD


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: KINGSVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

PHR: PROJECT NARRATIVE Glioblastoma stem-like cancer cells are believed to contribute to poor prognosis and high motility rates of glioma patients. Therefore, our novel strategies to specifically target the glioblastoma stem-like populations for elimination could have great clinical impact.

PI_NAMEs: SUNG, CHANG KYOO (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Adult;Automobile Driving;Binding;Biological Assay;Brain Neoplasms;Breast Carcinoma;cancer cell;cancer recurrence;Candidate Disease Gene;Cell Line;Cells;Chimeric Proteins;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Complex;CpG Islands;CRISPR/Cas technology;Death Rate;Development;Diagnosis;Disease Progression;DNA Methylation;Engineering;experimental study;Flow Cytometry;Gene Expression;Generations;Genes;Genetic Transcription;Glioblastoma;Glioma;glioma cell line;Goals;Human;Hypermethylation;innovation;Investigation;Knock-out;Maintenance;Malignant Neoplasms;Measures;Mediating;Methylation;Methyltransferase;Motility;mutant;novel;novel strategies;novel therapeutic intervention;Ovarian Carcinoma;Pancreatic carcinoma;Pathologic;Pathway interactions;Patients;Population;Prognosis;promoter;Property;Prostate carcinoma;Proteins;pyrosequencing;Recurrent tumor;Reporting;Repression;Role;self-renewal;Serum;spheroids;stem;stem cell biomarkers;stem cells;stem-like cell;stemness;Technology;Testing;Therapeutic;therapy resistant;Time;transcription factor;transcriptome sequencing;tumor;tumor initiation;vector;Western Blotting;World Health Organization

PROJECT_TITLE: Collaborative Activities of the Key Transcription Factors in Glioblastoma Stem-like Cancer Cells


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Systemic sclerosis (SSc) is a life-altering autoimmune disease that is overrepresented in Veterans due to service-related exposures. It has a progressive and mostly devastating course, with the highest mortality of all rheumatologic diseases. Although SSc affects many organs of the body, hardening of the skin is the most common and distinct feature and a primary cause of disability and decreased quality of life. Importantly, skin changes guide treatment. Recently, promising new therapies have emerged for SSc, but clinical trials of these therapies are hampered by the lack of reliable ways to measure the complexities of skin changes. To tackle this important clinical challenge, we propose a handheld device, the Myoton, that noninvasively and rapidly measures many mechanical attributes of the skin. We will rigorously validate the Myoton as a practical and objective tool to aid with SSc staging and evaluation in Veterans with this debilitating disease.

PI_NAMEs: TKACZYK, ERIC R (contact)

PROJECT_TERMS: Address;Affect;Agreement;Autoimmune Diseases;Benzene;Biological Markers;Biopsy;Caring;Cellular Phone;chronic graft versus host disease;Classification;Clinical;Clinical assessments;clinical phenotype;Clinical Trials;cohort;contaminated water;Cutaneous;Cutaneous sclerosis;Dermal;Devices;diagnostic biomarker;disability;Disease;Disease Marker;Disease Progression;Early Intervention;Edema;Enrollment;Evaluation;Evolution;Frequencies;graft vs host disease;handheld equipment;Histologic;Histology;Image Analysis;Impairment;improved;insight;instrument;Interobserver Variability;Life;Link;Lung;Lung Diseases;Machine Learning;Measurement;Measures;Mechanics;Morbidity - disease rate;mortality;Multi-site clinical study;novel therapeutics;Organ;Outcome Measure;Pathology;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Predictive Value;primary outcome;Protocols documentation;Provider;Quality of life;Reproducibility;response;Rheumatism;Scleroderma;Services;Severities;Severity of illness;Skin;skin biopsy;skin disorder;skin fibrosis;Staging;Standardization;Structure;subcutaneous;systemic autoimmune disease;Systemic Scleroderma;Testing;Therapy Clinical Trials;Thick;Time;Tissue Model;Tissues;tool;treatment response;Ultrasonography;ultrasound;user-friendly;Validation;Veterans

PROJECT_TITLE: Quantitative assessment of cutaneous systemic sclerosis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


FUNDING_MECHANISM: OTHERS

PHR: Project Narrative: Dr. Rhoades is an active VA investigator whose work seeks to identify novel therapeutic approaches to treating cancer induced bone diseases. Her current projects seek to target novel interactions between bone marrow macrophages and tumor cells using immune therapies in combination with tumor targeted therapies to reduce tumor growth, bone destruction, and bone marrow complications. These studies will impact Veteran populations, which have higher rates of invasive and metastatic tumors and lower survival rates, by identifying effective and less toxic therapies for patients with bone metastatic tumors including breast, head and neck cancer, and prostate cancer (which all impact Veteran disproportionately).

PI_NAMEs: RHOADES (STERLING), JULIE A (contact)

PROJECT_TERMS: Academic Medical Centers;Animal Model;anti-cancer research;anti-tumor immune response;Arkansas;Award;Biocompatible Materials;Biology;Biomedical Engineering;bone;Bone Diseases;Bone Marrow;Bone marrow failure;Breast;cancer therapy;carcinogenesis;career;Cause of Death;Cell Differentiation process;Cell Physiology;Cell secretion;Clinical;Collaborations;controlled release;curative treatments;cytokine;Dedications;Diagnosis;Disease;Disease-Free Survival;Drug Combinations;Environment;Ephrins;experience;Fracture;Funding;Funding Agency;Genetic Transcription;Goals;Grant;Growth Factor;Head and Neck Cancer;Homeostasis;Immune;Immune response;Immunologic Stimulation;Immunotherapy;improved;inhibitor;Innate Bone Remodeling;Interleukin-4;Journals;Laboratories;Macrophage;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;mechanical signal;Mediating;meetings;Mesenchymal Stem Cells;Metastatic breast cancer;Metastatic Neoplasm to the Bone;military veteran;Minerals;Molecular Target;monocyte;Multiple Myeloma;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;nano;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel;novel strategies;novel therapeutic intervention;Oncology;Osteoclasts;outcome prediction;parathyroid hormone-related protein;Patients;Pharmacodynamics;Pluripotent Stem Cells;Population;preclinical study;precursor cell;prevent;Production;Publications;Publishing;Quality of life;Regulation;Research;Research Personnel;response;Role;Scientist;side effect;Signal Transduction;Site;Skeleton;small molecule inhibitor;Societies;stem cell niche;Survival Rate;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic nanoparticles;transcription factor;Transforming Growth Factor beta;Translating;Trauma;tumor;tumor growth;Tumor-associated macrophages;United States National Institutes of Health;Universities;Veterans;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Infectious Diseases;Microbiome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: SURGERY

PHR: Project Narrative Biofilms are organized structures that allow microbes to shape their local environment in ways that provide optimal nutrients and protection to the microbial community. This proposal will evaluate the role of specific microbial proteins, glucosyl transferases, in generating multi-species biofilms and stabilizing colonies of bacteria that promote amphetamine use disorder.

PI_NAMEs: CARTER, ANGELA MICHELLE (contact);VELU, SADANANDAN E.

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: abuse liability;Aerobic;Affect;Amphetamine Abuse;amphetamine use;Amphetamines;Anaerobic Bacteria;Animal Model;Antibiotics;Attention Deficit Disorder;Bacteria;Bacterial Adhesins;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;behavioral response;Biochemical;Biological;Biological Assay;Biological Models;Biology;Brain;Butyrates;Cell membrane;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chemicals;Cocaine;Coculture Techniques;Communication;comorbidity;Complex;conditioned place preference;Cytoplasm;Data;Dental caries;Disease;Dopamine;dopamine transporter;Drosophila genus;Drosophila melanogaster;drug of abuse;Drug Targeting;dysbiosis;Electrophysiology (science);Environment;Enzymes;Etiology;experimental study;extracellular;Extracellular Matrix;Fusobacteria;Fusobacterium nucleatum;Gene Expression Profile;genetic approach;Gingivitis;Glucans;gram negative anaerobic rods;Growth;Histone Deacetylase Inhibitor;host colonization;Human;Human Microbiome;Immune response;Immunofluorescence Immunologic;In Vitro;in vivo;Intervention;Laboratories;Libido;Link;Locomotion;Measures;member;Membrane Proteins;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;Modeling;Molecular;Mus;National Institute of Drug Abuse;Nature;neuropsychiatric disorder;neurotransmission;novel;Nutrient;Opioid;organizational structure;overdose death;Pathogenesis;Pathway interactions;Periodontal Diseases;Pharmaceutical Preparations;pharmacologic;Physiological;polymicrobial biofilm;preference;presynaptic neurons;Property;Proteins;psychostimulant;Publishing;Quantitative Reverse Transcriptase PCR;response;Rewards;Rodent;Role;Science;Shapes;small molecule;Specificity;Stains;stem;Stimulant;Streptococcus mutans;Substance Use Disorder;Synapses;Techniques;Testing;transcriptome sequencing;Transferase;Translating;Up-Regulation;uptake;Work

PROJECT_TITLE: Microbial Biofilms as Regulators of Amphetamine Use Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-N (O1)]


NIH_SPENDING_CATS: Aging;Cancer;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Peripheral Neuropathy;Prevention;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE Older adults make up the largest proportion of cancer survivors. They are at the highest risk of poor medication-related outcomes. It is imperative that we determine the effect of age on centralized pain, quantify its management, and improve upon the care of older adult cancer survivors with pain.

PI_NAMEs: SMITH, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acetaminophen;Age;age effect;Age Years;Aging;American;Analgesics;cancer diagnosis;Cancer Survivor;Cancer Survivorship;cancer therapy;career;Caring;Categories;Central Nervous System;central pain;chronic pain;Classification;Clinical Decision Support Systems;clinical decision-making;Clinical Pharmacists;clinically relevant;Code;Complex;Data;Databases;Decision Making;design;Development;Diagnosis;Etiology;experience;Functional disorder;Future;Geriatrics;Goals;Guidelines;high risk;human old age (65+);improved;improved outcome;Individual;innovation;Interview;Knowledge;large datasets;Malignant Neoplasms;Mediating;Medicare;Mentors;Methods;multiple chronic conditions;Neuropathy;Nociception;older adult;Older Population;Oncologist;Opioid;opioid use;oral pain;Outcome;Outcomes Research;Pain;Pain management;Palliative Care;Participant;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physiological;Population;Practice Management;prescription opioid;Prevalence;Process;programs;Provider;Recommendation;Research;research clinical testing;Research Personnel;Research Project Grants;responsible research conduct;Risk;Scientist;Societies;survivorship;Testing;Training;United States;Work

PROJECT_TITLE: Centralized Pain Management In Older Adult Cancer Survivors

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Precision Medicine;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because, by contributing to characterize the neuroaffective and neurocognitive mechanisms that moderate individual responses to transcranial magnetic stimulation, it is the necessary preliminary step to develop personalized neuromodulation treatments for substance use disor- ders. Hence, this project is relevant to the NIDA Behavioral and Cognitive Neuroscience Branch mission of identifying the neurobiological mechanisms driving drug use disorders and guide treatment strategies.

PI_NAMEs: KYPRIOTAKIS, GEORGE ;VERSACE, FRANCESCO  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acceleration;Automobile Driving;Bayesian Method;Behavioral;Calibration;Clinical;Clinical Trials;clinically significant;cognitive control;cognitive neuroscience;Cues;Data;Development;Disease;drug craving;Drug usage;Drug Use Disorder;Electroencephalography;Enrollment;executive function;FDA approved;Future;Goals;improved;incentive salience;Individual;Individual Differences;individual response;Intervention;Knowledge;Measures;Methods;Mission;Modeling;National Institute of Drug Abuse;neural;neural network;neurobehavioral;neurobiological mechanism;Neurobiology;Neurocognitive;neuroregulation;Neurosciences Research;nicotine cue;nicotine self-administration;Outcome;Pharmaceutical Preparations;Phase;phase II trial;Phenotype;precision neuromodulation;Prefrontal Cortex;primary outcome;Probability;prognostic;Psychophysiology;Public Health;repetitive transcranial magnetic stimulation;Research;response;Rewards;Safety;Sample Size;Smoker;smoking relapse;stem;Structure;Substance Use Disorder;substance use treatment;success;Techniques;Testing;Therapeutic;Transcranial magnetic stimulation;treatment effect;Treatment outcome;treatment response;treatment strategy

PROJECT_TITLE: Bayesian neurobehavioral phenotyping: from mechanism identification to personalized neuromodulation treatments

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Pediatric;Physical Activity;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because, for youth with chronic kidney disease (CKD), cardiovascular disease (CVD) is a leading cause of morbidity and early mortality. Children and adolescents with Chronic Kidney Disease (CKD) are significantly less active than their peers, but effective strategies to promote physical activity and the extent to which physical activity and muscle strength mitigate CVD complications in this population are unknown. Supported by a multidisciplinary team with expertise in pediatric patient-oriented research, measurement of physical activity, and the use of digital technology to promote healthy behaviors, this award will 1) identify optimal intervention components to increase physical activity and 2) quantify the relationships between physical activity, muscle strength and CVD, in youth with CKD.

PI_NAMEs: KOGON, AMY  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Accelerometer;Address;Adolescent;Adult;aged;Award;Behavior;Behavior Therapy;Behavioral;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;Cessation of life;Child;Childhood;Chronic Kidney Failure;Clinical;clinical care;Clinical Trials;Clinical Trials Design;Cohort Studies;Conduct Clinical Trials;Data;Data Analyses;Diet;digital;digital technology;Echocardiography;effectiveness testing;efficacy testing;Engineering;Environment;Epidemiology;Event;Exercise;exercise intervention;Experimental Designs;Feedback;financial incentive;follow-up;Functional disorder;Funding;Goals;Hand;Hand Strength;Health;Health behavior;Health behavior change;health determinants;Health Promotion;Heart Abnormalities;Home;Improve Access;improved;indexing;innovation;Intervention;Intervention Studies;Isometric Exercise;Knowledge;Left Ventricular Hypertrophy;Left Ventricular Mass;Longevity;Measurement;Measures;Mentors;Mentorship;moderate-to-vigorous physical activity;Morbidity - disease rate;mortality;multidisciplinary;multiphase optimization strategy;muscle strength;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Neurocognitive;novel;novel marker;Obesity;Outcome;Participant;patient oriented research;Patient Self-Report;Pediatric Hospitals;pediatric patients;peer;Pennsylvania;Performance;Philadelphia;Physical activity;physical inactivity;Pilot Projects;Population;Positioning Attribute;post intervention;primary outcome;Proxy;psychosocial;Public Health;Quality of life;Randomized;reduced muscle strength;remote patient monitoring;Research;Research Activity;Research Personnel;Resources;Running;Science;secondary outcome;skills;Strategic Planning;Structure;Technology;Theory of Change;therapeutic target;Time;tool;Training;trial design;United States National Institutes of Health;Universities;Visit;web platform;Youth

PROJECT_TITLE: Physical Activity and Muscle Strength in Pediatric CKD

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]