NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine

PI_NAMEs: HEDEKER, DONALD  (contact)

PROJECT_TERMS: Animal Experimentation;Animal Experiments;anti-cancer research;Basic Science;Bioinformatics;Biostatistics Core;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;Case Report Form;cellular engineering;Chicago;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Data Monitoring Committees;Code;Collaborations;Comprehensive Cancer Center;Core Facility;Data;Data Analyses;Data Collection;data management;data quality;Databases;Dedications;design;Development;Education;Educational process of instructing;Ensure;Epidemiologist;epigenomics;epitranscriptomics;Evaluation;Formulation;Funding;Generations;genome wide association study;Genomics;Goals;Grant;high dimensionality;imaging approach;Immunotherapy;improved;innovation;investigator training;Journals;Laboratories;Literature;Malignant Neoplasms;Manuscripts;Medical;Medicine;member;Methodology;Monitor;multidimensional data;novel;Observational Study;Oncology;Participant;Peer Review;Phase;Phase III Clinical Trials;Population Sciences;Positioning Attribute;precision medicine;precision oncology;Preparation;prevent;Process;prospective;Proteomics;protocol development;Protocols documentation;Publications;Randomized;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Review Committee;RNA Sequence Analysis;Safety;Sample Size;Schedule;Services;Source;Statistical Data Interpretation;statistics;Strategic Planning;success;Therapeutic;Translational Research;translational study;tumor immunology;tumor metabolism;Universities;Variant

PROJECT_TITLE: Biostatistics Core Facility


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: LANGAN, GEORGE PARSONS (contact)

PROJECT_TERMS: Adopted;Antibodies;Award;Biotechnology;Calibration;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;Cells;Cellular Assay;cellular engineering;Charge;Chicago;Clinical Trials;Color;Comprehensive Cancer Center;Consult;Consultations;Core Facility;cost;Coupled;Cytometry;Data;Decontamination;design;detector;Development;epigenomics;epitranscriptomics;experimental study;Flow Cytometry;Funding;Generations;Grant;Hour;Human;Human Resources;Hybridomas;Image;imaging approach;Immunotherapy;improved;innovation;instrument;instrumentation;Journals;Label;Lasers;Malignant Neoplasms;Measurement;Measures;Medicine;member;Mission;Monitor;Noise;novel;Peer Review;Performance;Phenotype;Positioning Attribute;precision medicine;precision oncology;Process;Property;Protocols documentation;Publications;Quality Control;quantum;Reagent;Research Personnel;Running;Sampling;Services;Sorting;Strategic Planning;success;synthetic polymer Bioplex;Technology;Therapeutic;Time;tool;Training;translational study;tumor immunology;tumor metabolism;United States National Institutes of Health;Universities

PROJECT_TITLE: Cytometry and Antibody Technology Facility

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PI_NAMEs: WICKREMA, AMITTHA  (contact)

PROJECT_TERMS: Accreditation;Automation;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;CD34 gene;Cell Therapy;Cells;cellular engineering;Cellular immunotherapy;Chicago;Clinical;Clinical Trials;Comprehensive Cancer Center;Consultations;cost;Cyclic GMP;Dendritic Cells;Development;Doctor of Philosophy;Dose;engineered T cells;epigenomics;epitranscriptomics;Equipment;Faculty;Fractionation;Funding;Future;Goals;Good Manufacturing Process;Grant;Human;imaging approach;Immunologic Monitoring;Immunotherapy;Industry;injection/infusion;innovation;Investigational New Drug Application;Investments;Knowledge;Laboratory Finding;Lentivirus Vector;Malignant Neoplasms;manufacture;manufacturing environment;manufacturing process;Medicine;meetings;member;Methodology;novel;Oncolytic;Oncolytic viruses;Patients;Pharmacologic Substance;Phase;Philanthropic Fund;precision medicine;precision oncology;Preparation;Principal Investigator;Procedures;Process;Production;Regulation;Reporting;Research Personnel;scale up;Services;Site;Source;Strategic Planning;success;T-Lymphocyte;Therapeutic;Therapy Clinical Trials;Translating;tumor immunology;tumor metabolism;Universities;vector

PROJECT_TITLE: Current Good Manufacturing Practice Facility


PI_NAMEs: GILAD, YOAV  (contact)

PROJECT_TERMS: Address;anti-cancer research;Biological Assay;Biological Models;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;cellular engineering;Chicago;Chromium;Clinical;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Consultations;Core Facility;cost;cost effective;Data;digital;DNA sequencing;Doctor of Philosophy;Education;Epigenetic Process;epigenomics;epitranscriptomics;Equipment;Faculty;Formalin;Freezing;Funding;Generations;Genomic approach;Genomics;Human Resources;imaging approach;Immunotherapy;improved;In Situ;innovation;Journals;Leadership;Learning;Malignant Neoplasms;Medicine;member;Methods;Modernization;multiple omics;nano-string;next generation sequencing;novel;Paraffin Embedding;Peer Review;Peer Review Grants;population based;Positioning Attribute;precision medicine;precision oncology;Publications;Reagent;Research;Research Personnel;Resolution;Resource Sharing;Services;single cell analysis;Speed;Strategic Planning;success;Techniques;Technology;Therapeutic;Tissue Sample;tool;Training and Education;training opportunity;transcriptomics;tumor immunology;tumor metabolism;Universities;Variant;webinar

PROJECT_TITLE: Genomics Core Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine

PI_NAMEs: GAJEWSKI, THOMAS F (contact)

PROJECT_TERMS: assay development;Bioinformatics;Biological;Biological Assay;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;cancer immunotherapy;Cancer Patient;Cells;cellular engineering;Chicago;Clinical;Clinical Cancer Center;Clinical Trials;Comprehensive Cancer Center;Consultations;Core Facility;Data;design;Development;DNA;Doctor of Philosophy;epigenomics;epitranscriptomics;Evaluation;fluorescence imaging;Funding;Future;Genomic Data Commons;Genomics;Germ Lines;Grant;Heart;Histologic;host neoplasm interaction;Human;imaging approach;Immune;Immune response;Immunity;Immunologic Markers;Immunologic Monitoring;Immunologics;Immunology procedure;Immunotherapeutic agent;Immunotherapy;Infrastructure;innovation;Intervention;Investigation;Journals;Laboratories;Leadership;Malignant Neoplasms;marine;Measures;Medicine;member;Methodology;microbiome sequencing;Mission;Molecular;novel;Outcome;Patients;Peer Review;Peer Review Grants;peripheral blood;pharmacodynamic biomarker;Positioning Attribute;precision medicine;precision oncology;Preparation;Prognostic Marker;programs;prospective;Publications;Quality Control;Research Design;Research Personnel;Sampling;Services;single-cell RNA sequencing;stool sample;Strategic Planning;success;Therapeutic;transcriptomics;tumor immunology;tumor metabolism;tumor microenvironment;Universities

PROJECT_TITLE: Human Immunologic Monitoring Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Precision Medicine

PI_NAMEs: LINGEN, MARK W. (contact)

PROJECT_TERMS: Acceleration;Accreditation;Administrator;American;anti-cancer research;Authorization documentation;Bar Codes;Basic Science;biobank;Biological Specimen Banks;Biological Specimen database;Blood;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer imaging;cancer therapy;candidate marker;Categories;cellular engineering;Chicago;Clinical;Clinical Research;Clinical Trials;Collection;college;Comprehensive Cancer Center;Consent;Data;Databases;Dedications;demographics;Detection;Diagnostic;diagnostic criteria;digital pathology;DNA;Ensure;epigenomics;epitranscriptomics;Evaluation;fabrication;Feces;Funding;Future;Grant;Health Insurance Portability and Accountability Act;Histology;Histopathologic Grade;Histopathology;Human;human tissue;Image Analysis;imaging approach;Immunohistochemistry;Immunotherapy;improved;In Situ Hybridization;Infrastructure;innovation;Institutional Review Boards;Joints;Journals;laser capture microdissection;Lesion;Link;Maintenance;Malignant Neoplasms;Management Information Systems;Medicine;meetings;member;Mission;Molecular;Nature;novel;novel therapeutics;Nucleic Acids;Online Systems;Pathologic;Pathologist;Pathology;Patients;Peer Review;Peripheral Blood Mononuclear Cell;Plasma;Population Research;Positioning Attribute;precision medicine;precision oncology;Preparation;Prevention;Process;programs;Protocols documentation;Publications;Publishing;Quality Control;quantitative imaging;Reporting;Research;Research Activity;Research Personnel;Saliva;Sampling;Serum;Services;Specimen;square foot;Strategic Planning;success;System;Therapeutic;Thinking;Time;Tissue Microarray;tissue resource;Tissue Sample;Tissues;Translational Research;tumor immunology;tumor metabolism;Universities;Urine

PROJECT_TITLE: Human Tissue Resource Center


NIH_SPENDING_CATS: Bioengineering;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy

PI_NAMEs: GLICK, BENJAMIN S (contact)

PROJECT_TERMS: Ablation;Address;Animals;Basic Cancer Research;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;Cells;cellular engineering;Chicago;Clinical Trials;Color;Comprehensive Cancer Center;Computer software;cost;Data;deep learning;Dimensions;Education;education resources;epigenomics;epitranscriptomics;Equipment;experience;Fluorescence;Fostering;Funding;Future;Generations;Goals;Grant;Image;Image Analysis;imaging approach;imaging capabilities;Imaging technology;Immunotherapy;improved;innovation;Institution;instrumentation;Journals;Laboratories;Laser Microscopy;Light;Lighting;Maintenance;Malignant Neoplasms;Manufacturer;Medicine;member;Methods;Microscope;microscopic imaging;Microscopy;Molecular;new technology;novel;Organ;Output;Peer Review;Physiological;Physiological Processes;precision medicine;precision oncology;Publications;Rain;Reporting;Research;Research Personnel;Resolution;Scanning;Services;Site;Slide;Speed;Strategic Planning;Structure;success;superresolution microscopy;System;Techniques;Technology;Testing;Therapeutic;tool;translational cancer research;tumor immunology;tumor metabolism;ultra high resolution;Universities;University resources

PROJECT_TITLE: Integrated Microscopy Facility


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: CHEN, CHIN-TU  (contact)

PROJECT_TERMS: Anatomy;animal imaging;Animals;base;Biological;bioluminescence imaging;Breast;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;cancer therapy;cellular engineering;Chicago;clinical application;clinical translation;Clinical Trials;Collaborations;Colorectal Cancer;Comprehensive Cancer Center;Contrast Media;cost effectiveness;Cyclotrons;Detection;Development;Diagnosis;diffusion weighted;epigenomics;epitranscriptomics;Equipment;ex vivo imaging;experimental study;fluorescence imaging;Funding;Goals;Grant;Head and Neck Cancer;Image;image reconstruction;imaging approach;imaging capabilities;imaging modality;Imaging Techniques;Imaging technology;Immunotherapy;improved;in vivo imaging;innovation;Journals;Lung;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Measurement;Medicine;member;microPET;Modality;molecular imaging;Monitor;novel;optical imaging;Organ;outreach;Ovarian;Peer Review;Positioning Attribute;Positron-Emission Tomography;precision medicine;precision oncology;Preparation;Prostate;Protocols documentation;Publications;Radiolabeled;Recommendation;Reporting;Research;Research Personnel;Resources;Services;single photon emission computed tomography;Specimen;spectrograph;Spectrum Analysis;Strategic Planning;success;synergism;Technical Expertise;Therapeutic;Three-Dimensional Image;Tissue imaging;Tracer;translational applications;tumor immunology;tumor metabolism;ultrasound;Universities;Work

PROJECT_TITLE: Integrated Small Animal Imaging Research Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: MACLEOD, KAY F (contact)

PROJECT_TERMS: Address;animal model development;animal resource;Animals;anti-cancer research;Bacterial Artificial Chromosomes;blastocyst;Breeding;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;Cancer Model;Cell Culture Techniques;Cells;cellular engineering;Chicago;Chimera organism;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Comprehensive Cancer Center;cost effective;CRISPR/Cas technology;Custom;Derivation procedure;design;design and construction;Development;DNA;Educational workshop;Embryo;embryonic stem cell;Ensure;epigenomics;epitranscriptomics;Exclusion;Funding;Future;gene editing technology;Gene Targeting;Generations;Genetically Engineered Mouse;Genotype;Grant;Human Resources;imaging approach;Immunotherapy;Individual;Injections;innovation;Journals;Literature;Maintenance;Malignant Neoplasms;Medicine;member;Modeling;mouse model;Mouse Strains;Mus;Mutation;new technology;novel;novel strategies;Ownership;pathogen;Patients;Peer Review;Positioning Attribute;precision medicine;precision oncology;pregnant;Preparation;Production;Publications;Reporting;Research;Research Personnel;Resource Sharing;Service delivery model;Services;Site;skills;Southern Blotting;stem;Strategic Planning;success;Techniques;Technology;Therapeutic;Training;Transgenes;Transgenic Mice;Transgenic Mouse Facility;Transgenic Organisms;tumor immunology;tumor metabolism;Universities;vector

PROJECT_TITLE: Transgenic Mouse Facility


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: OVERALL: Targeting Cellular Senescence to Extend Healthspan—NARRATIVE In this Program Project Grant renewal application (Targeting Cellular Senescence to Extend Healthspan), our overall goal is to build a firm foundation of multidisciplinary discovery science in cellular senescence that leads to a pipeline of therapeutic strategies that slow or prevent age-associated diseases. Using a highly integrated approach across 3 Projects and 4 Cores, our work aims to provide fundamental insights into the mechanisms of cellular senescence and aging across bone, muscle, and brain; understand potential communications between these tissues in driving age-related dysfunction; and develop new drugs targeting cellular senescence and benefitting multiple aging tissues simultaneously.

PI_NAMEs: KHOSLA, SUNDEEP ;LEBRASSEUR, NATHAN K (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Adipose tissue;age related;age-related disease;Aging;aging brain;aging related;Applications Grants;Automobile Driving;Award;Behavior;bone;bone aging;Brain;CDKN2A gene;Cell Aging;cell type;Cells;cellular targeting;Clinic;Clinical Trials;Communication;Data;drug development;drug discovery;Engineering;Foundations;Functional disorder;Funding;Genetic Models;Geroscience;Goals;Grant;healthspan;in vivo;Individual;innovation;innovative technologies;insight;Institution;Intervention;K-Series Research Career Programs;Lead;Measures;Mediator;Minnesota;Molecular;molecular phenotype;mouse model;multidisciplinary;multiple omics;Muscle;muscle aging;new therapeutic target;next generation;novel;old mice;Organ;pharmacologic;Phenotype;Population;prevent;Principal Investigator;Productivity;Program Research Project Grants;programs;Property;Publications;Qualifying;Research;Research Activity;Research Project Grants;Role;Science;senescence;senescent cell;senolytics;senomorphic;Senotherapeutic;Skeletal Muscle;small molecule;Structure;success;Sum;Systems Biology;Therapeutic;Tissues;tool;Transgenic Model;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (J2)]


NIH_SPENDING_CATS: Aging;Biotechnology;Machine Learning and Artificial Intelligence

PI_NAMEs: LEBRASSEUR, NATHAN K (contact)

PROJECT_TERMS: Address;Adipose tissue;Administrative Coordination;age related;age-related disease;Aging;aging brain;aging mechanism;Applications Grants;Bioinformatics;Biology;Biology of Aging;Biometry;bone;Brain;Cell Aging;Cells;cellular targeting;Clinic;Clinical Trials;Collaborations;Communication;Data;data management;data sharing;deep learning;Dimensions;drug development;drug discovery;Ensure;experience;Foundations;Functional disorder;Funding;Genes;Genetic;Genetic Models;Geroscience;Goals;Grant;healthspan;Individual;Infrastructure;innovation;insight;Intervention;K-Series Research Career Programs;Leadership;Mediator;Methodology;Methods;Modeling;molecular phenotype;mouse model;multidisciplinary;Muscle;muscle aging;novel;novel strategies;Organ;pharmacologic;Positioning Attribute;prevent;Productivity;Program Research Project Grants;Publications;Qualifying;Recording of previous events;Research;Research Activity;Research Personnel;Resource Sharing;Role;Sampling;Science;senescence;Senotherapeutic;single cell analysis;skeletal;Skeletal Muscle;Structure;synergism;System;Systems Biology;Talents;Therapeutic;Tissues

PROJECT_TITLE: Core A - Administrative and Systems Biology of Aging Core (ASBC)


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

PI_NAMEs: MONROE, DAVID G (contact)

PROJECT_TERMS: Accounting;Age;age related;aged;Aging;aging related;Applications Grants;Archives;Biological Products;bone;Brain;Breeding;C57BL/6N Mouse;CDKN2A gene;Cell Aging;Cells;cellular targeting;Chronic Disease;cognitive testing;Cre driver;Data;Data Element;data management;data quality;Data Security;data standards;Development;Disease;Ensure;experimental study;frailty;Functional disorder;Funding;Gene Deletion;Genes;Genetic;Genetic Models;Goals;Grant;Health;healthspan;Human;in vitro testing;in vivo;in vivo evaluation;Individual;inducible Cre;Information Technology;innovation;interest;LoxP-flanked allele;Mediating;Methods;Modeling;Molecular;mouse genetics;mouse model;Mus;Muscle;novel;old mice;Pathologic;Pathway interactions;pharmacologic;Phenotype;Physiological;Productivity;Program Research Project Grants;Records;Risk Factors;Role;sample collection;Schedule;senescence;senolytics;Serum;Tamoxifen;Testing;Tissue Harvesting;Tissue Sample;Tissues;tool;tumor;tumorigenesis;Wild Type Mouse;Work

PROJECT_TITLE: Core B - Common Mouse Models Core (CMMC)


PI_NAMEs: ROBBINS, PAUL D. (contact)

PROJECT_TERMS: Ablation;Acceleration;age acceleration;age related;Age related comorbidities;age-related disease;aged;Aging;aging brain;analog;Apoptosis;Apoptotic;BCL2 gene;Biodistribution;Bioinformatics;Biological Assay;Biology of Aging;Biomedical Research;CDKN2A gene;Cell Aging;Cell Death;Cell Line;cell type;Cells;cellular targeting;Clinical;clinically relevant;Collaborations;combinatorial;Complex;Cyclin-Dependent Kinase Inhibitor 2A;Data;Drug Combinations;drug development;drug discovery;Drug Targeting;Drug usage;efficacy testing;Epigenetic Process;Family member;FDA approved;fisetin;Foundations;Functional disorder;Funding;Genetic;Goals;Health;Health Benefit;Health Sciences;healthspan;improved;in vivo evaluation;Induction of Apoptosis;Lead;Libraries;Lipids;Machine Learning;Measures;medical schools;Medicine;member;Metabolism;MicroRNAs;Minnesota;Modeling;Morbidity - disease rate;mouse model;multidisciplinary;Natural Products;Nerve Degeneration;normal aging;novel;old mice;Organ;Osteoporosis;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;prevent;Probability;Program Research Project Grants;Publishing;Reporter Genes;Rodent;Role;sarcopenia;Science;screening;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Senotherapeutic;single-cell RNA sequencing;Site;skeletal;skeletal muscle wasting;Specificity;standardize measure;Testing;Texas;Therapeutic;Tissues;Transgenic Organisms;Universities;Zoledronic Acid

PROJECT_TITLE: Core C - Drug Discovery and Development Core (DDDC)


PI_NAMEs: PASSOS, JOAO  (contact)

PROJECT_TERMS: age-related disease;aged;Aging;aging related;Algorithms;analytical tool;Animal Model;Biological Assay;Biological Process;bone;Brain;CDKN2A gene;Cell Aging;Cell Communication;Cell Nucleus;cell type;Cells;Cellular Assay;cellular targeting;Characteristics;Clinic;Collaborations;Complement;Complex;computerized tools;Cytometry;Data;Data Analyses;data integration;drivers of aging;Environment;Exhibits;Extracellular Space;Funding;Gene Expression;Genetic Complementation Test;Goals;healthspan;Heterogeneity;Image;image registration;imaging modality;imaging platform;imaging system;Imaging Techniques;Immune;Immunofluorescence Immunologic;In Situ;innovation;insight;Intervention;Knowledge;Maps;Messenger RNA;Methods;Modality;Molecular;molecular phenotype;multiple omics;multiplexed imaging;Mus;novel;Phenotype;Proteins;Proteome;proteomic signature;Proteomics;recruit;Research;Resolution;senescence;senescent cell;Senotherapeutic;Senotherapy;single cell technology;single nucleus RNA-sequencing;Skeletal Muscle;Source;Space Perception;Spatial Distribution;Technology;telomere;Tissues;tool;transcriptome;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: Core D - Senescence Molecular Phenotyping Core (SMPC)


PI_NAMEs: KHOSLA, SUNDEEP  (contact)

PROJECT_TERMS: Address;Adipocytes;age related;Age-Related Bone Loss;Aging;aging brain;analytical tool;AP20187;bone;bone aging;Bone Marrow;Brain;brain cell;brain dysfunction;CDKN2A gene;Cell Aging;Cells;cellular targeting;Complement 2;Cytometry;efficacy testing;extracellular vesicles;Gene Deletion;Genetic;genetic approach;Genetic Models;healthspan;human old age (65+);Image;in vivo;innovation;insight;Intervention;LOX gene;LoxP-flanked allele;Mediating;Mediator;Modeling;Molecular;molecular phenotype;mouse model;Mus;Muscle;muscle aging;Muscle Cells;novel;old mice;Osteoblasts;Osteocytes;pharmacologic;Phenotype;Population;prevent;Program Research Project Grants;Proteomics;Protocols documentation;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single-cell RNA sequencing;skeletal;Systems Biology;Tamoxifen;Testing;Time;Tissues;tool;Transgenes;tumor;Work

PROJECT_TITLE: Project 1 - Cellular Senescence and Bone Aging


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Sarcopenia

PROJECT_TERMS: Acute;age related;age related changes;age-related disease;Aging;aging brain;Apoptosis;Biopsy;bone;Brain;CDKN2A gene;Cell Aging;Cell Separation;Cells;cellular targeting;Chronology;Collaborations;Communication;Computational Biology;Coupled;Cytometry;Data;design;DNA Damage;Elderly;Exercise;exercise training;Exhibits;Female;Foundations;Functional disorder;Funding;Gene Expression Profile;Genetic;Genetic Models;Geroscience;Goals;healthspan;Heterogeneity;Histologic;HMGB1 gene;Human;Image;In Vitro;in vivo;Individual;Injury;innovation;insight;interest;Intervention;LoxP-flanked allele;Magnetism;male;Measures;Mediator;Messenger RNA;Metabolic;Molecular;molecular phenotype;mouse model;multidisciplinary;Mus;Muscle;muscle aging;muscle regeneration;next generation;novel;Nuclear;old mice;older men;older women;Organ;Performance;pharmacologic;Phenotype;Physical Function;Population;Positioning Attribute;postmitotic;prevent;progenitor;programs;promoter;Property;Protac;Proteins;Publishing;Regulation;Research;response;Role;Safety;safety testing;Science;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Senotherapeutic;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;skeletal muscle wasting;small molecule;Systems Biology;Tamoxifen;telomere;Testing;Therapeutic;Tissues;tool;trait;transcriptome sequencing

PROJECT_TITLE: Project 2 - Cellular Senescence and Skeletal Muscle Aging


PI_NAMEs: JURK, DIANA  (contact)

PROJECT_TERMS: Age;age effect;age related;Age-associated memory impairment;Aging;aging brain;aging hippocampus;Automobile Driving;Blood - brain barrier anatomy;blood-brain barrier permeabilization;bone;Brain;brain cell;CDKN2A gene;Cell Aging;cell type;Cells;cellular targeting;Chronic;Cognition;cognitive function;Collaborations;Communication;Computational Biology;Cytometry;Data;drug candidate;efficacy testing;Encephalitis;Endothelial Cells;frailty;Funding;Genetic;Goals;healthspan;healthy aging;Hemorrhage;Heterogeneity;Hippocampus;Image;Impaired cognition;improved;In Situ;In Vitro;innovation;insight;interest;Intervention;Investigation;LOX gene;LoxP-flanked allele;Mediating;Messenger RNA;Microglia;molecular phenotype;mouse model;multiple omics;Mus;Muscle;Musculoskeletal;neuroinflammation;novel;old mice;oligodendrocyte progenitor;Oligodendroglia;Organ;Pericytes;Pharmaceutical Preparations;pharmacologic;Physiological;Play;precursor cell;Process;Proteins;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Senotherapeutic;Senotherapy;single nucleus RNA-sequencing;Skeletal Muscle;small molecule;Systems Biology;Tamoxifen;Technology;Testing;Tissues;Transgenic Mice

PROJECT_TITLE: Project 3 - Cellular Senescence and Brain Aging


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE (OVERALL) Autoimmune endocrinopathies affects a large number of Americans- ~20 million are affected by thyroiditis, and 1.45 million are affected by Type 1 Diabetes. Despite this, immunotherapies are not the first-line treatment for this immune-mediated condition, and autoimmune endocrinopathies have not been a focus of previous ACEs. This proposal will define immune mechanisms that drive long-term autoimmunity seen in autoimmune endocrinopathies that will lead to identification of targets for new immunotherapies to benefit patients.

PI_NAMEs: SU, MAUREEN A (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Address;Adrenal gland hypofunction;Adverse event;Affect;Agreement;American;anti-PD-1;Arthritis;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmune Process;Autoimmunity;BCL6 gene;biobank;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Central Nervous System;Chronic;Clinic;Critical Pathways;Data;Demyelinating Diseases;Development;differential expression;Disease;Disease Progression;druggable target;Endocrine;Endocrinology;Ensure;Epigenetic Process;Etiology;FDA approved;Female;Funding;Genes;Genetic Transcription;Goals;Hashimoto Disease;Hormone secretion;Hormones;Hydrocortisone;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune Targeting;immune-related adverse events;Immunologist;Immunotherapeutic agent;Immunotherapy;Individual;Inflammatory;Infrastructure;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Link;male;Malignant Neoplasms;Mediating;multidisciplinary;Multiple Sclerosis;Newly Diagnosed;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Physiological;Pilot Projects;preservation;progenitor;programs;Psoriasis;Regulation;Research Personnel;restoration;Role;self-renewal;Sex Bias;Sex Differences;sexual dimorphism;side effect;standard of care;stem;System;T-Lymphocyte;tertiary lymphoid organ;Therapeutic Intervention;Thyroid Hormones;Thyroiditis;Tissues;transcription factor;Virus Diseases;Work

PROJECT_TITLE: Identifying new immunotherapeutic targets for endocrine autoimmunity.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (J1)]


NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

PROJECT_TERMS: Accountability;Autoimmune;Autoimmunity;Clinical Research;Collaborations;Communication;conflict resolution;Endocrine;Ensure;experience;Goals;Immunology;Immunotherapeutic agent;Infrastructure;innovation;Lead;Leadership;meetings;Mission;National Institute of Allergy and Infectious Disease;Organization administrative structures;organizational structure;outreach;Patients;Performance;Policies;Procedures;Productivity;programs;Publications;Records;Reporting;Research;Resources;Role;Services;synergism;System;timeline;United States National Institutes of Health

PROJECT_TITLE: UCLA ACE Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Immunotherapy;Infectious Diseases;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: BUTTE, MANISH J (contact)

PROJECT_TERMS: antagonist;Antigens;antiviral immunity;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;autoimmune pathogenesis;Autoimmune Responses;Autoimmunity;BCL6 gene;Beta Cell;Biological;Biological Assay;blood glucose regulation;CD8-Positive T-Lymphocytes;Cells;Chromatin;Chronic;Chronic Disease;chronic infection;Clinical;Competence;CRISPR/Cas technology;cytotoxic;Data;Development;Disease;Effector Cell;effector T cell;Endocrine;Epigenetic Process;epigenetic regulation;Face;Failure;Gene Expression;Genes;Genetic Transcription;genome editing;Goals;Guillain Barré Syndrome;Hashimoto Disease;Hormone secretion;Hormones;Human;Immune;Immune response;Immunotherapeutic agent;Immunotherapy;Impairment;Infection;Infiltration;Insulin;Insulin-Dependent Diabetes Mellitus;Interruption;Mediating;Mediator;Memory;Modeling;Molecular;mouse model;multiple omics;Mus;Myelin;new therapeutic target;novel therapeutic intervention;Onset of illness;Pathogenicity;Pathway interactions;Patients;peripheral blood;Peripheral Nervous System Diseases;Physiological;Play;Population;prevent;progenitor;Proliferating;Regimen;Residual state;Resources;Role;self-renewal;small molecule inhibitor;stem;stem cell population;stem cell self renewal;stem cells;Symptoms;T cell response;T-Cell Activation;Testing;Therapeutic;Thyroid Gland;Thyroid Hormones;Tissues;transcription factor;translational potential;Virus Diseases

PROJECT_TITLE: Mediators of chronicity in autoimmune endocrinopathies.


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: LECHNER, MELISSA G (contact)

PROJECT_TERMS: Acceleration;Affect;anti-PD1 therapy;antigen-specific T cells;Antigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;autoreactive T cell;B-Lymphocytes;BLR1 gene;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Cellular Structures;checkpoint inhibition;checkpoint therapy;Chronic;Clonal Expansion;Collection;comparison control;CXCL13 gene;CXCR6 gene;cytotoxic CD8 T cells;cytotoxicity;Data;Development;differential expression;Disease;Disease Progression;druggable target;Endocrine;Evaluation;Genes;Gland;Goals;Granzyme;Hashimoto Disease;Helper-Inducer T-Lymphocyte;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunotherapeutic agent;Immunotherapy;Individual;Indolent;insight;Interferon Type II;interleukin-21;Joints;longitudinal analysis;loss of function;Lung;Mediating;Memory;Methods;mouse model;Organ;Pancreas;Patients;Peripheral;Pituitary Gland;Play;progenitor;programmed cell death protein 1;Reporting;response;Role;single-cell RNA sequencing;Specimen;stem;T-Lymphocyte;targeted treatment;Techniques;tertiary lymphoid organ;Testing;therapeutic target;Thyroid Gland;Thyroiditis;Time;Tissues;trafficking;transcription factor;transcriptomics;tumor;Tumor Immunity;Virus Diseases

PROJECT_TITLE: Immune cell states in endocrine immune related adverse events (IRAEs)


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PROJECT_TERMS: Adrenal Glands;Affect;Androgens;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;autoimmune thyroid disease;Autoimmunity;Blood Glucose;Cancer Model;Cardiovascular system;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Chromosomes;Data;Death Rate;Development;Diabetes Mellitus;diabetic;Disease;Disproportionately impacts women;Effector Cell;effector T cell;Endocrine;Estrogens;Event;Female;Gene Dosage;Genes;Gonadal Steroid Hormones;Hashimoto Disease;Hormones;Human;Immunotherapeutic agent;Incidence;Insulin-Dependent Diabetes Mellitus;Klinefelter's Syndrome;Knowledge;Lead;Link;male;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;new therapeutic target;Non obese;Outcome;overexpression;Patients;personalized therapeutic;Phenotype;Pilot Projects;Play;Ploidies;Predisposition;Prevalence;prevent;progenitor;Reporting;restraint;Role;Sampling;Severities;sex;Sex Bias;Sex Chromosomes;Sex Differences;sex disparity;Signal Transduction;stem;stem cell differentiation;stem cells;stemness;T cell differentiation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptome sequencing;Viral;women versus men;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Determinants of sex disparities in autoimmune endocrinopathies.


ADMINISTERING_IC: FD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Project Narrative This FDA Vet-LIRN Cooperative Agreement Program will strengthen collaborative efforts among Federal, State and local resources to promote animal health and increase food safety and security efforts. This program will bolster laboratory testing by advancing methodologies used to detect animal food for adulterants and contaminants, protecting both food and companion animals and public health.

PI_NAMEs: SWINFORD, AMY  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: FDA Veterinary Laboratory Investigation and Response Network Cooperative Agreement Program


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BROOKINGS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: Project Narrative This goal of this application is to enhance the veterinary diagnostic capacity and capabilities of Animal Disease Research and Diagnostic Laboratory (ADRDL), South Dakota in support of improving the national food safety system. This project will allow ADRDL to participate in Veterinary Laboratory Investigation and Response Network (Vet-LIRN). Through this program, ADRDL will serve as a regional sequencing lab and also will perform diagnostic testing as required by Vet-LIRN.

PI_NAMEs: RUESCH, LAURA  (contact)

PROJECT_TITLE: Strengthening national food safety system by improving veterinary diagnostics


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative: The VDL will support the Vet-LIRN through participation in FDA/Vet-LIRN sample analysis in the event of an animal food/feed contamination event, providing analytical data to FDA for potential regulatory use, and participation in additional projects, i.e. method development and validation as determined and directed by the VPO. The VDL will maintain its infrastructure for diagnosis of bacterial contamination in order to provide this support.

PI_NAMEs: NAIKARE, HEMANT K (contact)

PROJECT_TITLE: UMN VDL Infrastructure Support to Build and Support Capacity to Respond to Animal Foodborne Outbreaks


ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Vet-LIRN Project Narrative- Feb., 2022 The Oregon Veterinary Diagnostic Laboratory (OVDL) wishes to continue its collaboration with the Food and Drug Administration Veterinary Laboratory Investigation and Response Network (Vet-LIRN) wherein the OVDL will provide sample analysis, analytical data for regulatory use, and support for small scale method development and validation. These veterinary diagnostic testing activities support the Vet-LIRN’s objectives of facilitating early detection of animal food/drug adulteration or contamination as a component of the FDA’s overall responsibilities in these endeavors. Surveillance and testing for feed contamination in our animal populations promotes public health by protecting our nation’s food supply as well and our companion animals.

PI_NAMEs: TORNQUIST, SUSAN J (contact)

PROJECT_TITLE: Vet-LIRN


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Virus-associated malignancies may account for an estimated 15 percent of all human cancers worldwide, which represents a significant component of the global cancer burden. Both HIV and EBV have documented associations with a number of malignancies and people living with HIV are at a higher risk of developing cancer despite antiretroviral treatments. This study aims to identify and characterize novel interactions between exogenous viral factors and endogenous retroviral oncogenes that play an essential role in virus-associated cancers.

PI_NAMEs: MARSTON, JEZ LIM (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;antiretroviral therapy;B-Lymphocytes;Cancer Burden;carcinogenesis;CD4 Positive T Lymphocytes;Cell Line;Cells;checkpoint inhibition;co-infection;cohort;Data;Data Set;Development;differential expression;DNA Sequence Alteration;DNA Transposable Elements;Elements;Endogenous Retroviruses;enhancing factor;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Evolution;extracellular;Family;Freezing;gene product;Genes;genetic element;Genetic Transcription;Genome;genomic locus;Goals;Hematologic Neoplasms;Herpesviridae;high risk;Highly Active Antiretroviral Therapy;HIV;HIV Infections;Human;Human Genome;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immunity;Immunocompetent;Immunosuppression;In Vitro;in vitro Model;in vivo;infected B cell;Infection;Integration Host Factors;Kaposi Sarcoma;knock-down;large cell Diffuse non-Hodgkin's lymphoma;Lentivirus Vector;Literature;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;Membrane;Modeling;Molecular;mortality;multiple omics;Non-Hodgkin's Lymphoma;novel;Nuclear;Oncogenes;Oncogenic;Oncogenic Viruses;Oncoproteins;overexpression;Pathogenicity;Patients;Persons;Play;Population;premalignant;Process;protein expression;Proteins;Renal Cell Carcinoma;Research;Retroelements;Role;Sampling;Signal Pathway;Signal Transduction;single cell sequencing;targeted treatment;Testing;Therapeutic;Tissues;tool;Transactivation;Transcript;transcriptome sequencing;transcriptomics;translational impact;tumor microenvironment;Tumor Tissue;tumorigenesis;tumorigenic;Variant;Viral;Virus;Virus Diseases;Virus Latency;virus related cancer;Work

PROJECT_TITLE: Identifying Endogenous Retroviral Factors in Viral Lymphomagenesis


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Diabetes;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This study is timely as its findings have the potential to address the concerns recently raised regarding the lack of clarity on managing pregnant women with blood pressure levels in the ranges of lower thresholds according to the 2017 American College of Cardiology/American Heart Association guidelines. The findings may also inform early clinical triage strategies and risk stratification of women with combinations of blood pressure categories in pregnancy and comorbid obesity and diabetes. The public health consequences of this study are enormous, given that the pregnancy and postpartum periods significantly impact long-term health of both women and their offspring.

PI_NAMEs: ZHU, YEYI  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Address;Admission activity;Affect;Agreement;American;American College of Obstetricians and Gynecologists;American Heart Association;Anti-Hypertensive Agents;Blood Pressure;blood pressure reduction;California;Cardiology;cardiovascular risk factor;Cardiovascular system;care systems;Categories;Cesarean section;Chronic;Clinical;clinical care;Clinical Data;Clinical Management;Cohort Studies;college;comorbidity;Comprehensive Health Care;Computerized Medical Record;Data;Diabetes Mellitus;Diagnosis;Diastolic blood pressure;Eclampsia;electronic medical record system;ethnic minority;fetal;fetus nutrition;Guidelines;Health;Hospitalization;Hypertension;hypertensive;Impairment;improved;Individual;Integrated Health Care Systems;intrapartum;Joints;Knowledge;Lead;Life;Malnutrition;Maternal complication;maternal morbidity;Maternal Mortality;Measurement;Measures;Monitor;Morbidity - disease rate;Neonatal;Neonatal Intensive Care Units;Newly Diagnosed;Obesity;offspring;Outcome;Overnutrition;Patients;Perfusion;Perinatal;personalized care;Pharmaceutical Preparations;Population;population based;Positioning Attribute;post pregnancy;postpartum care;postpartum complications;postpartum outcome;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Rate;pregnant;Pregnant Women;Premature Birth;prenatal;Public Health;racial minority;Recommendation;Research;Risk;risk stratification;severe maternal morbidity;Small for Gestational Age Infant;Time;Triage;Uncertainty;Weight;Woman;Women's Group

PROJECT_TITLE: Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum Complications

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Transmissible vaccines are being widely considered to control zoonotic diseases in animal populations, including Ebola, Marburg, Sin Nombre hantavirus, and rabies. However, before transmissible vaccines are introduced, the benefits and risks must be considered. This study will provide the first empirical estimate of how well a transmissible vaccine spreads, and it will determine whether adverse evolution has occurred due to the widespread use of a transmissible vaccine, or if not, whether it is likely to occur.

PI_NAMEs: KENNEDY, DAVID  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animal Diseases;Animals;Attenuated Vaccines;Benefits and Risks;Birds;Case Study;cohort;Communicable Diseases;Disease;Domestic Fowls;Ebola;Ecology;Economics;Evolution;experimental study;Farm;Genes;genetic evolution;Genetic Recombination;genome sequencing;Herd Immunity;Knowledge;Livestock;Marburgvirus;Marek Disease;Modeling;Oncogenic;pathogen;Population;Production;Rabies;Risk;Sin Nombre virus;surveillance study;Time;tool;transmission process;unvaccinated;Vaccinated;Vaccination;Vaccines;viral transmission;Virulence;Virulent;Virus;Virus Diseases;whole genome;Work;Zoonoses

PROJECT_TITLE: US-UK Collab: The consequences of transmissible vaccines on disease ecology and pathogen evolution: Marek's disease virus as a case study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(55)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_DEPT: SURGERY

PHR: Triple negative breast cancer (TNBC) has a propensity for high rates of metastasis compared to non- TNBC. Yet there are no effective targeted therapies to combat this aggressive disease. Using integrated pharmacological and genetic approaches, we will delineate novel copper signaling metabolic pathways for the development of novel therapeutic strategies against TNBC.

PI_NAMEs: MITTAL, VIVEK  (contact);VAHDAT, LINDA THERESA

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Affect;amine oxidase;Animal Model;anti-cancer therapeutic;Architecture;Atomic Force Microscopy;Binding;Bioenergetics;Biological Markers;breast cancer metastasis;Breast Cancer Patient;cancer cell;Cells;Chelating Agents;Clinical;Clinical Trials;clinically significant;cofactor;Collagen;combat;complex IV;Copper;crosslink;Deposition;Development;Disease;Distal;effective therapy;Enzymes;ERBB2 gene;Exhibits;Extracellular Matrix;FRAP1 gene;Future;Genetic;genetic approach;genetic manipulation;Glycolysis;Goals;high risk;Human;human data;hypocupremia;Impairment;Invaded;Investigation;Link;LOXL2 gene;Lung;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;metalloenzyme;Metals;Metastatic/Recurrent;Mitochondria;Modality;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oral;Organ;Outcome;Pathway interactions;patient subsets;Patients;pharmacologic;Phase;Phase II Clinical Trials;Phenotype;Population;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;programs;Progression-Free Survivals;Protein-Lysine 6-Oxidase;Proteins;randomized trial;randomized, clinical trials;Reporting;response;response biomarker;Role;Sampling;second harmonic generation imaging;Serum;Signal Transduction;stem cells;targeted treatment;Testing;tetrathiomolybdate;Therapeutic;Therapeutic Agents;thiomolybdate;Trace Elements;triple-negative invasive breast carcinoma;Tumor Angiogenesis;tumor microenvironment;Tumor Promotion;uptake;Work

PROJECT_TITLE: Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative The immune system in the uterus is required to fight infection while at the same time maintaining the pregnancy and protecting the pregnant person and the fetus. As pregnancy progresses, the immune system evolves to accommodate the unique needs of the pregnancy which changes over the course of gestation. This proposal aims to define the immune programs activated in response to infection with the ultimate goal of identifying novel diagnostic and therapeutic strategies to improve pregnancy outcomes.

PI_NAMEs: NOBLE, KRISTEN NICOLE (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Academic Medical Centers;Acute;Anti-Inflammatory Agents;Bacterial Infections;career;career development;CD80 gene;Cells;Chronic disability;Chronic Disease;Clinical;Collaborations;cytokine;Cytometry;Data;Depressed mood;Diagnostic;diagnostic biomarker;Diphtheria Toxin;Embryo;Environment;Evolution;Faculty;fetal;Fetal health;Fetal Membranes;Fetus;fighting;First Pregnancy Trimester;first responder;Genetic;Genetic Transcription;Gestational Age;Goals;High-Risk Pregnancy;Host Defense;Human;IL8 gene;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunofluorescence Immunologic;Immunologics;improved;In Situ;Infection;Inflammatory;Innate Immune Response;Innate Immune System;instructor;Interleukin-6;intraamniotic infection;K-Series Research Career Programs;Knowledge;Literature;Macrophage;Maternal and Child Health;Maternal-Fetal Exchange;Mentors;Mentorship;Modeling;monocyte;mouse model;multidisciplinary;Mus;Natural Immunity;Nature;Neonatology;next generation sequencing;novel diagnostics;novel therapeutic intervention;offspring;Organ;Outcome;pathogen;Pathologic;Persons;Phenotype;Physicians;Placenta;placental membrane;Placentation;Population;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;Preventive;programs;PTPRC gene;Publications;recruit;reproductive;Reproductive Immunology;Research;Resolution;Resource Sharing;response;Role;Running;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;skills;stillbirth;Streptococcal Infections;Streptococcus Group B;Surface;Systems Biology;Techniques;Technology;Testing;Therapeutic;Third Pregnancy Trimester;Time;Tissues;TNF gene;Training;Transgenic Organisms;Uterus;Vagina

PROJECT_TITLE: Gestation Dependent Immune Response to Group B Streptococcus Infection During Pregnancy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative: Effective tissue repair requires the delivery of immunomodulatory and reparative cues in a spatially and temporally controlled manner. Using bone regeneration as a model, this proposal aims to develop functionally engineered extracellular vesicles (FEEs) and deliver them in a spatially and temporally controlled manner using 3D printing technology. Successful completion of this work will result in the development of a technique that can be used to control inflammation and enhance tissue repair bone as well as other organ systems.

PI_NAMEs: COOPER, LYNDON F;GAJENDRAREDDY, PRAVEEN ;RAVINDRAN, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;3D Print;Activities of Daily Living;Address;Alginates;Anti-Inflammatory Agents;Architecture;Area;Binding;Biological Assay;Biological Models;Biology;bioprinting;BMP2 gene;Body System;Calvaria;Cartilage;Cells;Chronic;clinical translation;Complex;controlled release;craniofacial;craniofacial tissue;crosslink;Cues;cytokine;Defect;Dental;Development;Disease;Dose;Encapsulated;Engineering;Equilibrium;Event;Extracellular Matrix;extracellular vesicles;Genes;Goals;Growth Factor;Health;Histology;Hybrids;Hydrogels;Immunology;immunoregulation;Impairment;improved;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Injury;Ink;Kinetics;Knowledge;Laboratories;Macrophage;MADH7 gene;Measurement;Mediator;Mesenchymal Stem Cells;MMP2 gene;Modeling;monomer;Muscle;Musculoskeletal;Musculoskeletal System;Natural regeneration;Nerve;novel strategies;paracrine;Pathway interactions;Peptides;Phase;Play;Polymers;precision medicine;prevent;Printing;Process;Production;Property;protein expression;Rattus;recruit;regenerative;Regenerative Medicine;Regenerative pathway;repaired;Reporter;Role;scaffold;Signal Transduction;Site;spatiotemporal;Specific qualifier value;stem cell exosomes;stem cell therapy;stem cells;Structure;System;Techniques;Technology;technology platform;Testing;Therapeutic;Time;tissue injury;tissue regeneration;tissue repair;Tissues;tool;Work

PROJECT_TITLE: 3D Encapsulation, Bioprinting and Controlled Delivery of Functionally Engineered EVs (FEEs)

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The primary objective of this project is to provide analytical chemistry support to the FDA-CVM VetLIRN program to assure safe and contaminant-free animal feeds and animal-derived human foods and to assist in case diagnostic, surveillance, emergency response and recovery exercises as the need arises. The Toxicology Section of CAHFS has been an active participant in VetLIRN since its inception.

PI_NAMEs: POPPENGA, ROBERT HOWARD (contact)

PROJECT_TITLE: CAHFS Toxicology VetLIRN support


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Public Health Significance Pets are these days “members” of the modern family. As such, they share intimate contact with the people in the household. Veterinary diagnostic laboratories must be prepared to support public health efforts to improve human health through a One Health approach. Health is at the nexus of people, animals, and the environment.

PI_NAMEs: VELAYUDHAN, BINU  (contact)

PROJECT_TITLE: One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food


ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Microbial or chemical contamination of food or drugs poses a significant risk to both public and animal health and the laboratory testing supported by the Vet-LIRN program creates a mechanism for early detection of contaminated or adulterated animal feed or drugs. The network provides support for the required response capacity in the event of food- or drug- related animal injury or illness. Vet-LIRN directly supports national food safety and security through established protocols that coordinate efficient reporting to FDA and ensure a process to support rapid notification of appropriate public or animal health officials in a case of an emergency.

PI_NAMEs: DODD, KIMBERLY  (contact)

PROJECT_TITLE: Michigan State University VDL VetLRN 2022


ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative This FDA Vet-LIRN Cooperative Agreement Program will strengthen the overall food safety system in the USA. The agreement will increase CVMDL's capacity to detect animal health threats, including feed-born-related illnesses. These threats can affect animals raised for human consumption or companion animals that may have a detrimental impact on public health.

PI_NAMEs: RISATTI, GUILLERMO ROBERTO (contact)

PROJECT_TITLE: Vet-LIRN: Improving infrastructure and response capabilities at the Connecticut Veterinary Medical Diagnostic Laboratory


ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative: Through a collaboration with the FDA’s Veterinary Laboratory Investigation and Response Network (Vet-LIRN), the Louisiana Animal Disease Diagnostic Laboratory will work toward the common mission of promoting human and animal health by expanding our diagnostic capabilities and capacity for routine and emergency response. The continued support of laboratories in this network is crucial for strengthening national food safety by providing rapid detection and response in a large-scale outbreak or emergency event.

PI_NAMEs: ROY, ALMA  (contact)

PROJECT_TITLE: CVM VetLIRN Veterinary Dagnostic Laboratory Program (U18)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Infectious Diseases;Lung;Microbiome;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Microbial membrane vesicles are an important source of microbial metabolites that can influence human health and disease. Research into the factors that modulate their formation is in its infancy, and we need research to characterize how dietary agents like alcohol influence their pathogenic potential. This research may uncover new mechanisms of host-microbe interaction that could serve as targets for future therapeutic strategies.

PI_NAMEs: VILLAGELIU, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Accounting;Address;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;Bacteria;Bacterial Antibiotic Resistance;Bacterial Pneumonia;Biological;Cells;Chemicals;Chronic;Cirrhosis;Clostridium;cytokine;Data;Development;dietary;disability-adjusted life years;Disease;dysbiosis;effector T cell;Epithelium;Ethanol;Excretory function;Frequencies;Functional disorder;Future;Gastrointestinal tract structure;Goals;Growth;gut microbes;gut microbiota;Health;Host Defense;host-microbe interactions;Human;improved;In Vitro;Individual;Indoles;infancy;Infection;Inflammation;Inflammatory;insight;Interleukin-1;Interleukin-6;Intestines;Klebsiella pneumoniae;Lung;Lung immune response;Malignant Neoplasms;Mediating;Membrane;Membrane Potentials;metabolomics;microbial;microbiota;microbiota composition;Morbidity - disease rate;mortality;Mucosal Immunity;Mucous Membrane;Mus;novel;novel therapeutics;pathogen;Pathogenesis;Pathogenicity;Predisposition;Property;Proteomics;Research;Respiratory System;Respiratory Tract Infections;Risk;Role;Source;stool sample;Streptococcus pneumoniae;Stress;Substance Use Disorder;Testing;Therapeutic;Therapeutic Intervention;tissue injury;TNF gene;Tryptophan;Vesicle;years of life lost

PROJECT_TITLE: The role of alcohol-associated microbiota membrane vesicles in mucosal immunity


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARATIVE Colorado State University Veterinary Diagnostic Laboratory Participation in the  FDA Veterinary Laboratory Investigation and Response Network The Colorado State University Veterinary Diagnostic Laboratory is a state of the art, high-capacity diagnostic laboratory that has the capability of fulfilling the goals of the Vet-LIRN program. The CSUVDL can provide full veterinary diagnostic testing services for the Vet-LIRN program and will work with the program to investigate cases and contribute to the overall mission of the program.

PI_NAMEs: PABILONIA, KRISTY  (contact)

PROJECT_TITLE: CVM Vet-LIRN Veterinary DiagnosticLaboratory Program (U18) Clinical TrialsNot Allowed


ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: The FDA Vet-LIRN Veterinary Diagnostic Laboratory Program enables, nationwide, the analyses of animal diagnostic samples and animal food/drug products. The Program fills a gap for the FDA Office of Regulatory Affairs (ORA) regarding veterinary diagnostic samples that greatly facilitates early detection of and response to animal food/drug adulteration and contamination events. Through the Vet- LIRN program, FDA leverages the expertise of a national system of university, state and federal veterinary diagnostic laboratories to provide additional capacity and capability, obtain veterinary diagnostic information critical to ORA response, and strengthen the overall national food safety system.

PI_NAMEs: SNEKVIK, KEVIN ROY (contact)

PROJECT_TITLE: FDA Veterinary Laboratory Investigation and Response Network Cooperative Agreement Program-WA


ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative The Vet-LIRN program adds a unique component to FDA investigations and testing programs, by directly examining veterinary diagnostic samples to facilitate early detection of animal food and drug adulteration or contamination. The previous outbreak of Salmonella infantis in humans from commercial pet food, and melamine in dog food as well as infant formula directly highlight the importance of effective screening of animal food and tissues to prevent disease in humans. Virginia Tech Animal Laboratory Services (ViTALS) is fully accredited by the AAVLD, a member of NAHLN, and has been a member of the FDA CVM Vet-LIRN community since 2012, and has experience and expertise in testing clinical samples and can provide technical skill and support for ongoing outbreak testing.

PI_NAMEs: LAHMERS, KEVIN K (contact)

PROJECT_TITLE: CVM Vet-LIRN Veterinary Laboratory Diagnostic Program (U18)


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE A first-tier laboratory member of the Veterinary Laboratory Investigation and Response Network (Vet- LIRN) and also a non-cooperative agreement member of the Food Emergency Response Network (FERN) since 2005, the PADLS New Bolton Center Laboratory at the University of Pennsylvania provides comprehensive veterinary diagnostic services to the Commonwealth of Pennsylvania and the surrounding region, making it an ideal part of the Veterinary Laboratory Investigation and Response Network. Our diagnostic samples for toxicology, microbiology, molecular diagnostics, and pathology testing are most commonly submitted by veterinarians, but other clients include food animal producers, various government agencies, and veterinary diagnostic laboratories in other states that lack toxicology sections. Some analyses are requested as part of normal surveillance activities or routine necropsies, while others are associated with cases of excessive, unexpected, or otherwise unexplainable animal losses or illness that may potentially pose a risk to animal health and/or animal or human food safety.

PI_NAMEs: MURPHY, LISA  (contact)

PROJECT_TITLE: Animal and Animal Food Diagnostic Sample Analysis in Support of FDA Vet-LIRN Activities and Investigations


ORG_CITY: MISSISSIPPI STATE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative The purpose of this proposal is to provide increased sample analyses for the FDA-Vet-LIRN in the event of animal food or drug related illnesses or other large-scale animal food/feed emergency events requiring surge capacity testing of implicated diagnostic or animal food samples. This work will also provide increased capacity for Federal or State surveillance assignments and will be used to implement standardized analysis results through the usage of standardized methods, equipment platforms, analytical worksheets, and electronic reporting.

PI_NAMEs: PULIDO-LANDINEZ, MARTHA  (contact)

PROJECT_TITLE: Using MVRDL to increase the FDA Vet-LRN sample analysis capacity during animal food/feed emergency events


PHR: Project Narrative The objective this proposal is to provide infrastructure for sample analysis and surge capacity to the VetLIRN in the event of animal food or drug related emergency or as needed by the VetLIRN program. The funding will also be used for maintaining trained personnel and quality control procedures and for the proficiency testing procedures as appropriate.

PI_NAMEs: BANGOURA, BERIT  (contact)

PROJECT_TITLE: TVDIL Infrastructure for CVM VET-LRN Veterinary Diagnostic Laboratory Program


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Romano 2022 Project Narrative The FDA Vet-LIRN Cooperative Agreement Program will strengthen the nation's food safety system by increasing capacity and expanding capabilities to detect adulterated livestock feeds and pet foods. Contaminated livestock feeds could affect animals raised for human consumption, either via excessive tissue residues or animal losses. Many ingredients used in companion animal foods are also used in human food products, and contamination of these ingredients could also affect humans.

PI_NAMEs: ROMANO, MEGAN C (contact)

PROJECT_TITLE: FDA Vet-LIRN Veterinary Diagnostic Laboratory Cooperative Agreement Program funding to increase sample analysis in the event of animal food or drug related illness


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_STATE: IL

PHR: Project Narrative High grade serous ovarian cancer (HGSOC) has a dismal prognosis, largely attributed to late diagnosis and poor responses to standard of care treatment. It is therefore essential to better understand the mechanisms of HGSOC development in order to identify potential strategies for early intervention, particularly in high-risk patients. In this proposal, we outline a series of experiments exploring the relationship between norepinephrine signaling and fallopian tube derived high grade serous cancer spread to the ovary in hopes of developing a new strategy to prevent or delay the development of HGSOC, ultimately improving clinical outcomes.

PI_NAMEs: BERGSTEN, TOVA  (contact)

PROJECT_TERMS: Address;Adrenergic Agents;Adrenergic beta-Antagonists;advanced disease;Adverse effects;Anabolism;antagonist;beta-2 Adrenergic Receptors;beta-adrenergic receptor;Cancer Biology;Cancer Patient;Cells;Chemicals;Chemoprevention;Clinical;Clinical Management;clinical practice;Coculture Techniques;Communication;cost;CRISPR/Cas technology;Cues;Data;Development;Diagnosis;Disease;Disease Progression;Distant Metastasis;drug repurposing;Early Intervention;Epithelial Cells;Epithelium;Event;expectation;experimental study;FDA approved;Goals;high risk;Human;Immunotherapy;improved;improved outcome;inhibitor;insight;Invaded;Lesion;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;malignant phenotype;Mammalian Oviducts;mass spectrometric imaging;Mediator;migration;Molecular;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Norepinephrine;novel strategies;Osteonectin;Outcome;Ovarian;ovarian neoplasm;Ovary;overexpression;paracrine;Pathway interactions;Patient Care;Patients;Peritoneal;Pharmaceutical Preparations;pharmacologic;Physicians;PI3K/AKT;precision medicine;prevent;Production;Prognosis;Propranolol;Radiation therapy;receptor;Refractory;Regulation;release factor;response;Rest;Role;Scientist;Series;Serous;Signal Transduction;small hairpin RNA;Soil;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard of care;System;Techniques;Testing;Time;TP53 gene;Training;Translating;tumor;tumor progression;Tumor Promoters;Tumor Suppressor Proteins;tumorigenic;Up-Regulation;Woman;Xenograft procedure

PROJECT_TITLE: Regulation of primary metastasis in high grade serous ovarian cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Lung;Neurosciences;Pain Research;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Children who are critically ill and receiving mechanical ventilation are at increased risks for experiencing high levels of stress and pain, which negatively impacts immediate and long-term health. The current standard of care for treating stress and pain is to provide analgesic and sedative medications, which are associated with increased risk of delirium and posttraumatic stress disorder. This randomized crossover trial will compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit, to identify the key components of a music listening intervention and explore its mechanism of action, i.e., the biological pathway through which music listening decreases stress and pain.

PI_NAMEs: JARVIS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: acceptability and feasibility;Acute;Adrenal Glands;Adult;Affect;aged;Analgesics;Area;Autonomic nervous system;beta-Endorphin;Biological;Biological Markers;Brain;career;career development;Caregivers;Certification;Child;Childhood;clinical implementation;Clinical Trials;cohort;Credentialing;Critical Care;Critical Illness;Critically ill children;Cross-Over Trials;Data;Delirium;design;Dopamine;dosage;efficacy evaluation;efficacy testing;Electrocardiogram;Elements;experience;Family;Focus Groups;Frequencies;Functional impairment;Funding;Future;Goals;Graph;Group Interviews;Health;Heart Rate;heart rate variability;Hour;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immobilization;Impaired cognition;Impairment;implementation barriers;improved;individual response;Inflammation;Intensive Care;Interleukin-6;Intervention;Interview;Intubation;Knowledge acquisition;Linear Regressions;Measurement;Measures;Mechanical ventilation;Mediating;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modeling;Monitor;multidisciplinary;Music;Narcotics;neurochemistry;Nonpharmacologic Therapy;Outcome;Pain;pain symptom;Participant;Pathway interactions;Patients;Pediatric Intensive Care Units;pediatric patients;Pediatrics;Periodicity;Personal Satisfaction;Pharmaceutical Preparations;Pharmacy facility;Physical Medicine;Physical Rehabilitation;Physics;Physiological;Physiology;Pilot Projects;Pituitary Gland;Post-Traumatic Stress Disorders;preference;prevent;professor;programs;prospective;Randomized;remediation;Research;research and development;Research Personnel;Respiration;respiratory;Respiratory Failure;Rewards;Risk;Safety;Saliva;Sampling;Science;Sedation procedure;sedative;Series;skills;sound;standard of care;Stress;stress reduction;stress symptom;Stressful Event;Structure;survivorship;Swab;Syndrome;Testing;therapy development;Time;Titrations;Training;treatment as usual;United States National Institutes of Health;Universities;Variant;vibration

PROJECT_TITLE: Music listening interventions for children receiving mechanical ventilation: A mechanistic trial

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mechanistic studies of uterine vascular adaptations to normal and abnormal pregnancies hold a great promise for identifying new management approaches and therapeutic interventions to treat and or even to prevent hypertension-related pregnancy disorders such as preeclampsia. This RO1 application aims to fill a knowledge gap on a physiological and pathophysiological role of new uterine vasodilator system hydrogen sulfide (H2S) in uterine hemodynamic regulation in hope for exploring therapeutic potential of H2S in preeclampsia.

PI_NAMEs: CHEN, DONGBAO  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Anabolism;angiogenesis;Animal Model;Animals;Arteries;Bathing;Biochemical;Biopsy;Blood flow;Blood Vessels;Cardiovascular system;Clinical Trials;Coculture Techniques;Coupled;Cystathionine;Cysteine;Data;Endothelial Cells;Endothelium;Enzymes;Estrogens;Family;Fetal Growth Retardation;Fetus;Functional disorder;Genetic Transcription;hemodynamics;high risk;Human;Hydrogen Sulfide;Hypertension;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;infancy;Knowledge;Lyase;Mediating;Mediator;Methods;Modeling;Molecular;multidisciplinary;Myography;Myometrial;myometrium;Nitric Oxide;normotensive;novel;Nutrient;Organ;Ovariectomy;overexpression;Oxides;Oxygen;pharmacologic;Physiological;Play;Potassium Channel;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy health;pregnant;Pregnant Women;pressure;prevent;Production;Productivity;Rattus;Regulation;Reporting;Research;Role;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;tool;translational approach;ultrasound;Up-Regulation;Uterus;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vasodilation;Vasodilator Agents;Woman;Work

PROJECT_TITLE: H2S and Uterine Vasodilation in Pregnancy and Preeclampsia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE We aim to increase the efficacy of lung cancer screening with low dose computed tomography (LDCT) by developing methods to accurately predict risk of lung cancer and/or progressive obstructive lung disease at the time of screening. Our approach will focus on objective biomarkers: LDCT derived radiomic biomarkers of lung structure and an epigenetic biomarker of smoking exposure.

PI_NAMEs: SIEREN, JESSICA C (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Accounting;Adult;Affect;airway obstruction;American;American College of Radiology Imaging Network;American Lung Association;automated segmentation;Benign;Biological Assay;Biological Markers;cancer epidemiology;cancer risk;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chest;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoking;Cities;Clinic;Clinical;Clinical Data;clinical diagnosis;cohort;Computational algorithm;computed tomography screening;Computers;CYP1A1 gene;Data;Diagnostic Imaging;Diagnostic tests;digital;Disease Progression;DNA;DNA Methylation;Early Diagnosis;Early treatment;Eligibility Determination;epigenetic marker;Epigenetic Process;Exposure to;former smoker;Grant;Heterogeneity;High Resolution Computed Tomography;Image;image processing;improved;interest;Lesion;Lobar;low dose computed tomography;Lung;lung cancer screening;Lung Diseases;Lung nodule;Machine Learning;machine learning classification;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;meetings;Methods;Methylation;methylation testing;Modeling;mortality;Nodule;Obstructive Lung Diseases;Outcome;Patient Self-Report;Performance;Persons;Population;predictive modeling;Predictive Value;Predisposition;prevent;prospective;Pulmonary Emphysema;Radiation exposure;Radiology Specialty;radiomics;Reporting;repository;Research;Research Subjects;Risk;Risk Factors;risk prediction;risk prediction model;Sampling;screening;Screening for cancer;Shapes;shared decision making;Smoking;Smoking Cessation Intervention;smoking exposure;Smoking History;Structure;Structure of parenchyma of lung;Testing;Texture;Thoracic Radiography;Tobacco;tobacco control;tobacco exposure;Tobacco use;trial enrollment;tv watching;United States Department of Veterans Affairs;Universities;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Lung cancer screening efficacy enhanced through radiomic and epigenetic biomarkers

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Ataxia Telangiectasia;Cancer;Genetics;Immunotherapy;Neurodegenerative;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: DERMATOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE In this project, we propose to examine a novel hypothesis that inhibition of the DNA double strand break response gene ATM can improve cancer immunotherapy and radiotherapy. If our hypothesis is proven correct, it will lead to better strategies for cancer therapy. Therefore, our study is highly relevant to public health.

PI_NAMEs: LI, FANG ;ZHANG, JENNIFER YUNYAN  (contact);ZHONG, XIAOPING

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Abscopal effect;anti-cancer research;anti-PD1 therapy;Antibodies;ataxia telangiectasia mutated protein;ATM deficient;ATM gene;Biogenesis;Biological;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;checkpoint therapy;clinical trial readiness;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Communities;Consensus;Data;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA-PKcs;Down-Regulation;experimental study;Face;Genetic;Genomic approach;Goals;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune signaling;Immunotherapy;improved;in vivo;Inflammatory;inhibitor;insight;Interferon Type I;Knock-out;knockout gene;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;Minority;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Mus;Mutation;Natural Immunity;neoplastic cell;novel;novel strategies;Outcome;pancreatic cancer model;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Play;Public Health;Radiation therapy;Radiation Tolerance;response;restraint;Role;Signal Pathway;small molecule inhibitor;Source;Stimulator of Interferon Genes;synergism;T memory cell;T-Lymphocyte;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Targeting ATM to boost systemic effects of radiotherapy and immunotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Communication and quality of life are greatly impaired by the loss of intelligibility that accompanies motor speech disorders such as Parkinson’s disease, cerebral palsy, and amyotrophic lateral sclerosis. The proposed studies refine a well-studied mechanism of speech learning, sensorimotor adaptation, to maximize its effects on intelligibility. By directly increasing vowel distinctiveness in speakers, and by characterising mechanisms underlying the variability, generalization, and retention of learning, this project takes the first steps to translate sensorimotor adaptation into a clinical tool for improving the efficacy of spoken communication.

PI_NAMEs: NIZIOLEK, CAROLINE  (contact);PARRELL, BENJAMIN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Amyotrophic Lateral Sclerosis;Apraxia;Attention;Auditory;auditory feedback;Awareness;Behavior;Behavior Control;Behavior Therapy;Behavioral;Brain;Brain Diseases;Brain Injuries;Categories;Cerebral Palsy;Characteristics;Clinical;clinical application;clinical practice;Clinical Research;clinically relevant;Cognitive;Communication;Complex;Conscious;Data;Development;Disease;Dysarthria;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;evidence base;experience;experimental study;Feedback;Foundations;Future;Impairment;improved;Individual;ineffective therapies;inter-individual variation;Intervention;Learning;life span;Limb structure;Link;Mental Depression;Motor;motor learning;Movement;Neurobiology;neuroimaging;Neurologic;neuroregulation;novel;Parkinson Disease;Pathway interactions;patient population;Patients;Perception;Persons;Population;Production;Quality of life;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Research;respiratory;Role;Sensory;Social isolation;Speech;Speech Disorders;Speech Intelligibility;Testing;Time;tool;Training;Transcranial magnetic stimulation;transfer learning;Translating;treatment optimization;Work

PROJECT_TITLE: Establishing the clinical utility of sensorimotor adaptation for speech rehabilitation

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSCIENCES

ORG_STATE: PA

PHR: Many neurological impairments cause localized damage to movement-related brain regions (e.g. motor neuron degeneration in ALS, or the areas surrounding an infarction following a stroke). Despite such damage, motor abilities often recover, or even persist without immediate deficit, owing to poorly understood compensatory changes amongst neural circuits distributed across unaffected parts of the brain. In this project, I will develop a platform for monitoring neuronal activity in multiple descending pathways that control brainstem orofacial circuits (in cortex, the superior colliculus, and the medulla itself) in order to determine the principles by which these pathways normally operate during movement—as well as how they adapt following brain damage in order to maintain stable motor output.

PI_NAMEs: MACHADO, TIMOTHY ALOYSIUS (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Advisory Committees;Aging;Amyotrophic Lateral Sclerosis;Anger;Animals;Area;Arousal;Automobile Driving;Behavior;Behavioral;Behavioral Assay;Brain;Brain Injuries;Brain region;Brain Stem;Cell Nucleus;Chronic;Chronic Brain Injury;Communities;comparative;Compensation;Degenerative Disorder;Disease;Dorsal;Electrophysiology (science);Ensure;experience;experimental study;Face;Faculty;Fright;Future;Generations;Goals;Image;Impairment;Individual;Infarction;Injury;Learning;Lesion;Link;Logic;Measures;Memory;Mentors;Mentorship;Methods;Monitor;Motor;motor behavior;Motor Cortex;motor neuron degeneration;Motor Neurons;Motor output;Motor Pathways;mouse model;Movement;Mus;Nervous System;neural;neural circuit;Neurologic;Neurons;optogenetics;orofacial;Pathway interactions;Phase;Play;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Pyramidal Tracts;recruit;Red nucleus structure;Reflex action;Research;Rewards;Role;Sensory;Signal Transduction;Stroke;Structure;superior colliculus Corpora quadrigemina;System;Technology;tenure track;Thirst;Training;Universities;Use of New Techniques;Water;Work

PROJECT_TITLE: Brainwide Computations Underlying Future Action Plans

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Chemical Biological Discovery of Lipid Virulence Factors in Major Bacterial Pathogens As contrasted with ubiquitous bacteria in the environment, certain bacteria acquire virulence factors that allow them to infect and cause disease in humans. Using a new system for rapidly detecting all ionizable lipids in the major Gram negative enteric and mycobacterial pathogens, we will discover the particular lipids that promote virulence to allow new approaches to treat infectious disease.

PI_NAMEs: MOODY, DAVID BRANCH (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acceleration;Address;Autophagocytosis;Bacteria;Bacterial Chromosomes;Biological;Biological Process;Biology;Catalogs;Cell model;Cells;Cellular Assay;Chemical Structure;chemical synthesis;Chemicals;Chromosome Mapping;Communicable Diseases;comparative;comparative genomics;Cord Factors;Data;Databases;Detection;Development;Diagnosis;Disease;Enteral;Environment;Evolution;experience;experimental study;Feedback;Foamy Macrophage;forward genetics;Functional disorder;Gene Deletion;gene discovery;gene function;Gene Modified;Generations;Genes;genetic approach;Genomics;Genus Mycobacterium;Gram-Negative Bacteria;Hour;Human;Immune response;Immunologic Receptors;in vivo;Infection;Infectious Diseases Research;inhibitor;insight;invention;Laboratories;Link;lipidome;lipidomics;Lipids;Literature;Location;Lysosomes;Macrophage;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;metabolomics;Methods;Modernization;Molecular;Mus;mycobacterial;Mycobacterium tuberculosis;Names;Nature;novel strategies;Nucleosides;Nutrient;Organism;overexpression;pathogen;pathogenic bacteria;Patients;Phenotype;Phospholipids;prenyl;Process;Production;Proteins;Proteomics;rapid detection;receptor;response;reverse genetics;Role;Salmonella;Salmonella enterica;Salmonella typhi;Science;selective expression;Signal Transduction;Study Section;success;System;T cell response;Testing;tool;Transcript;transcriptomics;translational study;Virulence;Virulence Factors;Virulent;Whole Organism

PROJECT_TITLE: Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial Pathogens

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

ORG_CITY: MANHATTAN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE  The goal of our project is to understand the mechanisms by which muscle sensory neurons contribute to exaggerated increases in sympathetic nervous system activity and blood pressure during exercise in cardiovascular disease. The experiments are significant because an exaggerated increase in sympathetic nerve activity results in vasoconstriction of the coronary and peripheral vasculature which leads to reduced exercise capacity and inadequate oxygen delivery to the heart and other tissues. Increasing our understanding of the mechanisms that cause the exaggerated increase in sympathetic nerve activity during physical stress may lead to the development of novel treatment options for cardiovascular disease patients.

PI_NAMEs: COPP, STEVEN W (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Adverse event;Afferent Neurons;Animal Experiments;Animals;Biological;Blood Pressure;Calcium;Calcium Signaling;Cardiac;Cardiovascular Diseases;Cardiovascular system;Chronic;Conscious;Contracts;coronary vasoconstriction;Cyclic AMP;Data;Development;Diameter;Disease;Electrophysiology (science);Ensure;Event;Exercise;exercise capacity;exercise intolerance;Exertion;experimental study;Feedback;femoral artery;Goals;Health;Heart;high risk;Hindlimb;Hour;Hypersensitivity;Inflammatory;innovation;inorganic phosphate;Inositol;insight;Investigation;Ischemia;Laboratories;Ligation;limb ischemia;Literature;mechanical force;Mechanics;mechanotransduction;Modeling;Molecular;Muscle;Myocardial Infarction;Nature;Nerve;novel;Oxygen;pain model;pain signal;Patients;Peripheral;Peripheral arterial disease;Phosphorylation;Play;Population Group;Pre-Clinical Model;Protein Kinase C;Proteins;Publications;Rattus;receptor;Receptor Signaling;Reflex action;Reflex control;Risk;Role;Sensory;Signal Pathway;Signal Transduction;Skeletal Muscle;Stress;Stroke;Sympathetic Nervous System;Techniques;Testing;Tissues

PROJECT_TITLE: Signaling pathways regulating mechanoreflex sensitization in cardiovascular disease

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE One potential mechanism that contributes to impairment in fragile X syndrome and the FMR1 premutation is autonomic nervous system (ANS) dysfunction. While ANS dysfunction has been linked to impairment, research has not examined the presence, onset, developmental trajectory, or developmental consequences of ANS dysfunction or the role of molecular-genetic factors. This project addresses these critical gaps and will have tremendous impact by greatly expanding information on the mechanistic underpinnings, biological pathways, and timing of symptom progression, which is essential to identify targets and timing of treatment to reduce symptom severity in fragile X syndrome and the FMR1 premutation.

PI_NAMEs: ROBERTS, JANE E (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Address;Adult;Adult women;Affect;Age;Anxiety;Arousal;autism spectrum disorder;autism symptoms;Autonomic nervous system;Behavior;Behavioral;Biological;CGG repeat;Child;Data;Development;Dimensions;experience;Female;FMR1 gene;FMR1 Premutation;Fragile X Premutation;Fragile X Syndrome;Functional disorder;General Population;Genetic;Genetic Variation;heart function;Heart Rate;Impairment;improved;indexing;Individual;infancy;Infant;Inherited;Intellectual functioning disability;interest;Intervention;Knowledge;Learning;Length;Life;Link;male;Measures;Messenger RNA;Molecular Genetics;Mutation;Outcome;Pathway interactions;Persons;Phenotype;Physiological;prospective;reduce symptoms;Research;respiratory;response;Risk;Role;Sensory;sensory stimulus;Severities;Sinus Arrhythmia;skills;social communication;social communication impairment;Symptoms;Time;Work

PROJECT_TITLE: Autonomic and Sensory Dysfunctions in FMR1 Conditions: Development, Mechanisms and Consequences

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Allosteric integrase inhibitors are a promising class of antiretroviral drug compounds. Herein we will elucidate the mechanism of allosteric integrase inhibitor drug action in part focusing on the host cell factor LEDGF, and characterize new complexes between integrase and host factors with the goal to define new targets for future drug development.

PI_NAMEs: ENGELMAN, ALAN N. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Active Sites;Address;Allosteric Site;Anti-Retroviral Agents;antiretroviral therapy;antiviral drug development;Applications Grants;Binding;Binding Proteins;Binding Sites;Biochemical;burden of illness;Capsid;Catalytic Domain;Categories;Cells;Clinic;Clinical;clinical development;Coin;Color;comparative;Competence;Complex;Dedications;Development;dimer;Disease;DNA;DNA Integration;drug action;Drug Compounding;drug development;Drug resistance;Drug Targeting;Enzyme Inhibition;Enzymes;Formulation;Funding;Future;Generations;Genes;Genetic Transcription;Goals;Grant;Growth Factor;HIV;HIV vaccine;HIV-1;HIV-1 integrase;HIV/AIDS;Image;In Vitro;Incidence;Infection;inhibitor;Integrase;Integrase Inhibitors;Integration Host Factors;Learning;lens epithelium-derived growth factor;meetings;Morphogenesis;mortality;mutant;Mutation;novel;Output;Paper;particle;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Phenocopy;pleiotropism;pre-clinical;pre-exposure prophylaxis;Property;Proviruses;Publications;pyridine;quinoline;Recommendation;Regimen;Research;Resistance;Reverse Transcriptase Inhibitors;Ribonucleoproteins;Role;Seminal;Structure;success;thienopyridine;transcriptional coactivator p75;viral DNA;Virion;Virus;virus host interaction;Work;young adult

PROJECT_TITLE: Biochemical Mechanism of HIV DNA Integration


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Cardiovascular disease is common and contributes to the morbidity and mortality of our patients. The longterm goal and the clinical significance of this proposal are to define the initial factors that govern the stem cell/progenitors to promote the formation of new vessels in response to injury or disease. The results from these studies will serve as an important platform for therapeutic initiatives focused on cardiovascular disease.

PI_NAMEs: GARRY, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adult;Affect;Algorithms;American;Applications Grants;ATAC-seq;Binding;Bioinformatics;Biological Assay;Biology;Biotechnology;Blood;Blood Vessels;Bypass;Cardiac;cardiac regeneration;cardiac repair;Cardiovascular Diseases;Cardiovascular system;Caring;Cellular biology;ChIP-seq;Chromatin;Chronic;clinically significant;Communication;conditional knockout;Coronary Artery Bypass;Data;Development;Diabetes Mellitus;Disease;Dissection;DNA;Embryo;Embryonic Development;Endothelium;Engineering;Fibroblasts;Future;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Models;Genetic Transcription;Goals;Heart Injuries;Hematopoietic;In Vitro;in vivo;Incidence;Inflammatory;Injury;innovation;knock-down;Knockout Mice;limb amputation;Machine Learning;Maps;Mediating;Medical;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;Morbidity - disease rate;Morphogenesis;mortality;mouse model;Mus;mutant;Natural regeneration;Nature;neovascularization;novel;novel therapeutics;Nucleosomes;Obesity;Pathway interactions;Patients;Peripheral arterial disease;progenitor;programs;Publications;Publishing;recruit;Regulator Genes;Research;response to injury;revascularization surgery;Role;single-cell RNA sequencing;SMARCA4 gene;SMARCA5 gene;Societies;Specific qualifier value;stem cells;TAL2 gene;Therapeutic;Therapeutic Intervention;transcription factor;Vascular Diseases

PROJECT_TITLE: Cardiovascular regeneration and pioneer factors

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Pulmonary Fibrosis is a fatal interstitial lung disease with a median survival of 3-5 years, accounting for ~45,000 deaths/ year in the United States. Currently there are no effective therapies and lung transplantation remains the only option to improve lung function and improve quality of life and survival. Understanding the mechanisms that initiate and promote fibrosis will aid in developing novel therapeutics to block or reverse this disease.

PI_NAMEs: TATA, PURUSHOTHAMA RAO  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Ablation;Accounting;Address;Alveolar;Alveolar Cell;alveolar epithelium;alveolar homeostasis;Biological Assay;Cell Fate Control;Cells;Cessation of life;Clinical;clinically relevant;Coculture Techniques;Communication;Coupled;Data;design;Disease;Ectopic Expression;effective therapy;Epithelial Cells;epithelial injury;Equilibrium;Experimental Models;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;Future;Gases;Genetic;Genetic Transcription;genome wide association study;Goals;Histologic;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Injury;injury and repair;Interstitial Lung Diseases;Ligands;loss of function;Lung;lung regeneration;Lung Transplantation;Maps;Mediating;Mesenchymal;Modeling;Molecular;mouse model;Mus;Myofibroblast;Natural regeneration;novel;novel therapeutics;Outcome;Pathogenesis;Pathologic;PDGFA gene;PDGFRA gene;pharmacologic;Population;prevent;programs;Proliferating;Pulmonary Fibrosis;pulmonary function;Quality of life;receptor;Recurrence;Regenerative Medicine;response;RUNX1 gene;Serum;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Slice;Specimen;Testing;Therapeutic;therapeutic development;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Transforming Growth Factor beta;United States;Work

PROJECT_TITLE: Cellular crosstalk and molecular mechanisms in the initiation and progression of pulmonary fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


PHR: PROJECT NARRATIVE The N-glycan branching pathway controls immunity and inflammation by controlling turnover rates of proteins on the surface of T cells. However, which proteins are regulated in this manner, and how this pathway promotes expression of some proteins while inhibiting expression of others is unknown. We propose using a quantitative proteomic approach to analyze all surface proteins simultaneously and to examine the hypothesis that these extracellular glycans cooperate with intracellular endocytosis machinery to differentially regulate cell- surface protein turnover.

PI_NAMEs: MKHIKIAN, HAIK  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Anti-Inflammatory Agents;Asparagine;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;CD4 Positive T Lymphocytes;CD8B1 gene;Cell membrane;Cell Physiology;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cellular biology;Clathrin;Complex;Coupled;crosslink;CTLA4 gene;Data;Diagnostic;Endocytosis;Endocytosis Pathway;Endoplasmic Reticulum;Enzymes;Epitopes;extracellular;Face;Family;Galactose Binding Lectin;Glycoproteins;glycosylation;Goals;Immunity;immunoregulation;Individual;Inflammation;Inflammatory;insight;Knowledge;knowledgebase;Lectin;Letters;Mannose;Mass Spectrum Analysis;Measures;Mediating;Membrane;Membrane Proteins;Mentors;Methodology;Methods;Modeling;Molecular;Monosaccharides;Mutagenesis;N-acetyllactosamine;novel strategies;Outcome;Pathway interactions;Physiological;Polysaccharides;protein degradation;protein expression;Protein Secretion;Proteins;Proteome;Proteomics;receptor;receptor expression;Receptor Signaling;Recycling;Regulation;response;Rest;Role;Structure;Surface;T cell regulation;T-Cell Activation;T-Cell Development;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapeutically effective;virtual

PROJECT_TITLE: Differential regulation of T cell plasma membrane proteins by N-glycan branching and clathrin-mediated endocytosis