NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  To treat wounds that won’t heal for patients with Recessive Dystrophic Epidermolysis Bullosa, we have developed induced pluripotent cell (iPS)-cell derived, scaleable induced skin composites (iSC) and find that TFAP2 and GRHL2-dependent regulate surface ectoderm signaling, with reciprocal GATA3-Gibbin dependent mesodermal signaling controlling surface ectoderm stratification and graftable iSCs. Using newly developed reagents, we will dissect the spatial and temporal TFAP2-GRHL2 driven early surface ectoderm commitment and elucidate the mechanism of Gibbin-dependent mesoderm regulation of epidermal stratification, with successful completion providing deep mechanistic insights into multi-lineage tissue differentiation, provide disease-relevant mechanistic insights into surface ectoderm- related developing tissues, and establish a detailed epigenetic characterization that enables development of our novel cell therapy for a previously untreatable genetic skin disorder.

PI_NAMEs: ORO, ANTHONY E (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;Binding;Binding Sites;Biological Markers;Cell Line;Cell Nucleus;Cell Therapy;Cells;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cyclic GMP;Data;Data Commons;Databases;Dermis;Development;Disease;DNA Methylation;Ectoderm;Enhancers;enhancing factor;Epidermolysis Bullosa Dystrophica;epigenetic memory;Epigenetic Process;Epithelium;Excision;flexibility;Fluorescence;GATA3 gene;gene network;Genetic;healing;Human;improved;In Vitro;in vivo;induced pluripotent stem cell;insight;keratinocyte;Knowledge;Maintenance;manufacture;Maps;Mediating;melanocyte;Mesoderm;morphogens;multiple omics;Mus;mutant;Mutant Strains Mice;novel;Output;Patients;Pattern;Performance;prevent;Process;programs;promoter;Proteins;Reagent;Regulation;response;rho GTP-Binding Proteins;Signal Pathway;Signal Transduction;Skin;skin disorder;Stratification;Stratification Factors;Surface;Surface Ectoderm;Syndrome;System;TFAP2A gene;Tissue Differentiation;Tissues;trafficking;transcription factor;Work;wound treatment

PROJECT_TITLE: Chromatin Dynamics During Epithelial Commitment

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Hypertension is a key risk factor for the development of cerebral small vessel disease, the foremost source of vascular cognitive impairment, the second most common cause of dementia after Alzheimer’s disease. Given the prevalence of hypertension rises from 46% of U.S. adults aged 20-44 to >78% of U.S. adults above the age of 65 and that hypertension incidence increases dramatically post-menopause in there is a critical public health need for a greater understanding of the mechanistic link(s) between sex, age-dependent hypertension and vascular cognitive impairment. Our collaborative research strategy, which is directly aligned with NIA Stratetgic Goals that address Alzheimer's disease and its related dementias, will define the sex dependent mechanistic sequelae of events and underlying neural dysfunction that is associated with age-dependent hypertension-driven vascular cognitive impairment and potentially identify new therapeutic targets and approaches for the treatment age-dependent hypertension-driven vascular cognitive impairment.

PI_NAMEs: FARB, DAVID H;WAINFORD, RICHARD DAVID (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Address;Adult;age related;aged;Aging;Alzheimer's Disease;Angiotensin II Type 1 Receptor Blockers;antagonist;Attenuated;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Pressure;blood pressure reduction;blood pressure regulation;Cardiovascular system;Cerebral small vessel disease;Cerebrum;Clinical;Cognition;cognitive function;cost of dementia;Data;Dementia;design;Development;Electrophysiology (science);Event;Exhibits;Female;female sex hormone;Functional disorder;Goals;Gonadal Hormones;healthy aging;Hemorrhage;Hippocampus;human old age (65+);Hypertension;hypertensive;Impaired cognition;improved;Incidence;innovation;insight;Link;Maintenance;male;mild cognitive impairment;Modeling;multidisciplinary;neural circuit;Neurocognitive;neuroinflammation;Neuronal Dysfunction;Neurons;neuroprotection;neuroregulation;Neurosciences;new therapeutic target;normal aging;novel;Outcome;Ovariectomy;paraventricular nucleus;Play;Postmenopause;Prevalence;Public Health;Rattus;Receptor, Angiotensin, Type 1;Research;Risk Factors;Rodent;Role;sex;Source;Specialist;Sprague-Dawley Rats;Testing;Vascular Cognitive Impairment;vascular injury;Woman

PROJECT_TITLE: Age-related Hypertension and Vascular Cognitive Impairment


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Binge alcohol consumption poses a major public health burden in the U.S., leading to increased rates of mortality and other pathophysiologies, such as anxiety and depression. The proposed work will examine how repeated cycles of binge-like alcohol drinking dysregulate serotonin signaling in a discrete neural circuit, which may drive future binge alcohol intake and contribute to negative health outcomes. This may lead to the identification of more effective therapeutic strategies for the treatment of alcohol use disorder.

PI_NAMEs: PINA, MELANIE M (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Anxiety;Award;binge drinking;Brain;career;Cells;Chronic;Classification;Complex;Confocal Microscopy;Death Rate;Development;Electrophysiology (science);experience;experimental study;Fluorescent in Situ Hybridization;Fostering;Functional disorder;Future;gamma-Aminobutyric Acid;Grant;Health;hippocampal pyramidal neuron;Impairment;Individual;Intake;Interneurons;Knowledge;Measures;Mental Depression;Mentors;Molecular;mRNA Expression;Mus;nerve supply;neural circuit;Neurons;novel;Outcome;Parents;Parvalbumins;patch clamp;Pattern;Phase;Population;Postdoctoral Fellow;Public Health;Pyramidal Cells;Receptor Signaling;Reporter;Research;Risk;Role;Series;Serotonin;serotonin receptor;Serotonin Receptor 5-HT1A;Signal Transduction;Site;Somatostatin;Synaptic Transmission;System;Techniques;therapeutically effective;Training;treatment strategy;Work

PROJECT_TITLE: Alcohol-Induced Alterations in Orbitofrontal Cortex Serotonin Signaling

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative This project will build a data repository for bone tissue studies that will be an open and free resource for the research community. In doing so, this repository will provide advanced ways to research the regulation of bone tissue ultimately leading to better ways to treat different human skeletal diseases.

PI_NAMEs: MAYE, PETER  (contact);ROWE, DAVID W.;SHIN, DONG-GUK

PROGRAM_OFFICER_NAME: SRINATH, ASUR R

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Archives;Asia;Back;Biological Assay;Biology;bone;Bone Tissue;Communities;computer infrastructure;computer scientist;Computers;Coupled;Data;data access;Data Collection;data ingestion;data interoperability;data repository;Data Set;Data Sources;database design;Database Management Systems;Databases;design;Development;Development Plans;digital;Educational workshop;Ensure;Europe;experience;FAIR principles;Genotype;Goals;High Performance Computing;Human;human disease;human model;Individual;Ingestion;innovation;insight;International;interoperability;meetings;member;Metadata;Methods;mindfulness;multidisciplinary;Mutant Strains Mice;natural language;North America;online repository;Ontology;Patients;Phenotype;phenotypic data;Privacy;Process;Regulation;repository;Research;Research Personnel;Resource Development;Resources;Rodent;Running;Sampling;Secure;Security Measures;skeletal;skeletal disorder;System;Talents;Technology;Testing;Therapeutic;Time;user-friendly;web portal;web site;Work;working group

PROJECT_TITLE: Archiving and Sharing Skeletal Phenotyping Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Lung;Pain Research;Physical Activity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: This study seeks to discover the reason why patients with long COVID suffer from persistent chest pain symptoms. Using advanced magnetic resonance imaging (MRI), this study will determine: (a) whether MRI accurately and precisely detects blockage in small blood vessels supplying oxygen to the heart in long COVID patients; (b) whether the said blockage is the cause of persistent chest pain symptoms in long COVID patients; (c) whether the said blockage resolves better with medicine. Our findings will inform future clinical trials aimed at preventing and/or reversing persistent chest pain caused by long COVID.

PI_NAMEs: KIM, DANIEL  (contact);LEE, DANIEL CHING-HAO

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: acute COVID-19;Age;Americans with Disabilities Act;Arrhythmia;asymptomatic COVID-19;Biological Markers;Blood;Blood flow;Blood Vessels;Breathing;Cardiac;Cardiopulmonary;Cardiovascular Abnormalities;cardiovascular health;Cardiovascular system;Chest Pain;Chronic;Cicatrix;Classification;Clinical;Clinical Trials;Contrast Media;Control Groups;Coronary;Coronary Arteriosclerosis;cost;COVID-19;COVID-19 patient;COVID-19 survivors;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic tests;Diffuse;disability;Endothelium;Enrollment;Ethnic Origin;exercise capacity;exercise intolerance;Exercise Test;extracellular;Fibrosis;Functional disorder;Funding;Future;Gadolinium;Grant;Healthcare;Heart;Heart Diseases;heart imaging;hemodynamics;Image;imaging facilities;imaging modality;improved;indexing;Inflammation;Injury;Ionizing radiation;Ischemia;Knowledge;Left Ventricular Ejection Fraction;Long COVID;Lung;Magnetic Resonance;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Matched Case-Control Study;Measures;Medical Imaging;Medicine;Microvascular Dysfunction;Modality;Myocardial;Myocardial perfusion;Oxygen;pain patient;pain symptom;parent project;Patients;Perfusion;perfusion imaging;Pericardial body location;persistent symptom;Positioning Attribute;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;Protocols documentation;pulmonary function;Race;Radioactive Tracers;Recording of previous events;Resources;Risk Factors;SARS-CoV-2 infection;Severities;sex;Stress;Symptoms;Testing;Time;tomography;United States National Institutes of Health;Vaccines

PROJECT_TITLE: Diversity Supplement: Quantitative Detection of Coronary Microvascular Dysfunction in Long COVID Patients using a Comprehensive, Rapid, Free-Breathing Cardiovascular MRI


NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Coronaviruses;Genetics;Human Genome;Lung;Organ Transplantation;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Fibrosis;Rare Diseases;Transplantation

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  The tremendous diversity across lung diseases is well acknowledged but coarsely defined. Leveraging recent advancements in single cell and spatial transcriptomic technologies, we will fulfill the mission of LungMAP phase III by conducting direct cross-disease comparisons at the single cell resolution. We expect that the datasets that we will generate and make publicly available will seed paradigm-shifting studies by the collective research community to uncover high resolution disease-specific mechanisms.

PI_NAMEs: SUN, XIN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Allografting;Alveolar;Alveolar Cell;Alveolus;ATAC-seq;Biology;Biopsy;Bronchi;Bronchiolitis Obliterans;Bronchopulmonary Dysplasia;cell community;Cell Nucleus;cell type;Cells;Characteristics;Childhood;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Communities;Computational Biology;Data;Data Set;Development;Dimensions;Disease;Elastin;epigenomics;Etiology;Exhibits;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;Fluorescent in Situ Hybridization;Functional disorder;Gases;Human;idiopathic pulmonary fibrosis;Immune;Ischemia;Lesion;Lung;lung allograft;Lung Diseases;Lung Transplantation;Maps;mechanical force;mechanical signal;Mesothelium;Mission;Monitor;multimodality;multiple omics;Mus;Myofibroblast;Natural regeneration;Nature;Nerve Endings;Neuroendocrine Cell;Neuroimmune;Nomenclature;Operative Surgical Procedures;Organoids;Pathogenesis;Pathogenicity;Pathology;Pattern;Phase;Pleura;Pleural;post-COVID-19;post-transplant;premature;prevent;progenitor;Protocols documentation;Publishing;Pulmonary Fibrosis;Pulmonology;Reaction;recruit;Research;Resolution;resource guides;Sampling;SARS-CoV-2 infection;severe COVID-19;Signal Transduction;single cell technology;Slice;Smoking;Surface;symposium;Syndrome;technological innovation;Technology;Testing;Time;Tissue Procurements;transcriptome sequencing;transcriptomics;Transitional Cell;Transitional Epithelium;Visit;Writing

PROJECT_TITLE: Cross-Disease Multi-Modality Mapping of the Human Lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Public Health Relevance Statement We will employ a mixed methods approach to evaluate potential paradigm-shifting approaches to xylazine testing and assessment of associations between xylazine exposure and skin and soft tissue infection rates while also assessing the context surrounding risks, outcomes, and willingness to be treated. Through multiple testing modalities and longitudinal assessments, our proposed study will provide an enhanced understanding of xylazine exposure over an extended timeframe and more precise measures of association with SSTIs. In addition, we will conduct qualitative interviews with people who have experienced SSTIs to better assess the context surrounding xylazine exposure, other risk factors, and SSTIs.

PI_NAMEs: SHRESTHA, SHIKHAR  (contact);STOPKA, THOMAS J

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: Adverse effects;Affect;Allergic Reaction;Area;Awareness;Biometry;Blood flow;Care given by nurses;Case Study;Communicable Diseases;Communities;comorbidity;Complex;Cox Proportional Hazards Models;Data;Drug Adulterations;drug testing;Drug usage;drug use behavior;Drug user;Evaluation;Evaluation of Risk Factors;Excipients;experience;Exposure to;Fentanyl;Frequencies;Goals;Habits;Harm Reduction;Health;Healthcare;high risk;Housing;Hygiene;Illicit Drugs;illicit opioid;improved;Incidence;Individual;Infection;infection rate;infection risk;Infectious Disease Epidemiology;Infectious Skin Diseases;Injecting drug user;Injections;interest;Intervention;Interview;Laboratories;Massachusetts;Measurement;Measures;Mediating;Methods;Modality;Modeling;Morbidity - disease rate;mortality;Necrosis;Needle Sharing;novel;Opioid;Outcome;Overdose;overdose death;Patient Self-Report;Patients;Perception;Periodicals;Persons;Pharmaceutical Preparations;Phenothiazines;prospective;protective effect;protective factors;psychosocial outcome;public health relevance;Publishing;Qualitative Evaluations;Qualitative Research;recruit;Regimen;Reporting;Research;Risk;Risk Factors;risk mitigation;Risk Reduction;Sampling;Sedation procedure;Site;skills;skin lesion;skin ulcer;Soft Tissue Infections;Specimen;substance use;Syringes;test strip;Testing;Time;Tissues;United States National Institutes of Health;Urine;Variant;vasoconstriction;willingness;wound care;Xylazine

PROJECT_TITLE: Examination of Xylazine Exposure and the Risk of Skin and Soft Tissue Infections in People Who Inject Drugs

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Ovarian Cancer;Patient Safety;Rare Diseases;Rehabilitation;Uterine Cancer;Vaginal Cancer;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Patients with advanced ovarian and uterine cancer experience severe functional decline from symptomatic burden. The choice of treatment and timing is predominantly age-based and dependent upon subjective assessments by surgeons, and the balance of over- and under-treatment in prolonging survival against the harms of aggressive surgery and chemotherapy may be better achieved through objective frailty assessments. This study proposes to utilize an existing research infrastructure to objectively assess physical frailty and deeply characterize its quantitative associations with treatment side effects, functional recovery, and quality of life to ultimately improve the ability of our field to assess these risks and make treatment decisions that align with outcomes important to older adults.

PI_NAMEs: CHAM, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Abdomen;Acceleration;Adult;advanced disease;Adverse event;Age;aggressive therapy;Aging;Albumins;Algorithms;Ascites;Award;Cancer Center;cancer diagnosis;Cancer Patient;Caring;chemotherapy;Chronic;Chronology;cohort;Cohort Studies;Data;Data Set;Databases;Death Rate;Decision Making;Dedications;Diagnosis;Disease;Dose;Elderly;Ensure;Equilibrium;evidence base;Excision;Exclusion;experience;Fatigue;Foundations;frailty;functional decline;functional independence;Future;Gait speed;Geriatrics;Goals;Guidelines;Gynecologic Oncology;Hand;Hand Strength;high risk;Home;Hypoalbuminemia;improved;innovation;Intestines;Intra-abdominal;Liver;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malnutrition;Measures;Mentorship;Modeling;Muscular Atrophy;Newly Diagnosed;novel;older adult;older women;Operative Surgical Procedures;Outcome;overtreatment;patient oriented;patient population;Patient-Focused Outcomes;Patients;Perioperative;Perioperative complication;perioperative morbidity;Physical assessment;physical inactivity;Physicians;Physiological;Population;Postoperative Period;postoperative recovery;Predictive Value;Procedures;prospective;Prospective Studies;Proxy;Quality of life;Quality of Life Assessment;randomized trial;Recommendation;Recovery of Function;Reporting;Research;Research Infrastructure;Research Personnel;Risk;Risk Assessment;risk prediction;Scientist;screening;Splenectomy;Surgeon;survival outcome;Symptom Burden;tool;treatment choice;Treatment Side Effects;Uterine Cancer;Variant;Work

PROJECT_TITLE: Promoting gynecologic cancer patients with frailty to achieve functional recovery cohort study (PROOF Cohort Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: MAYWOOD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE The formation of a new memory requires a rapid increase in the synthesis of messenger RNAs via the process of gene transcription in the brain, and many of the molecular processes underlying gene transcription regulation are disrupted in cognitive disorders. Rapidly inducible gene transcription requires a set of factors that regulate a poised, ready for activation, state within the nucleus, but how this poise is established has not been investigated in neurons. This project will examine the molecular players that regulate the poised state before, during, and after neuronal stimulation to understand whether they influence the capacity of the brain to form memories.

PI_NAMEs: GREER, CELESTE BRITTANY (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Alzheimer's Disease;Animal Behavior;Animals;Behavior;behavior test;Behavioral;Binding;Biochemical;Biological Assay;Brain;Brain Diseases;brain dysfunction;Calcium;Calcium Channel;Calcium Signaling;career;Cell Nucleus;cell type;Cells;Co-Immunoprecipitations;Cognition Disorders;cognitive process;Complex;Confocal Microscopy;Data;Dependence;Dependovirus;Dissociation;Environment;Enzymes;Event;experimental study;Faculty;Fluorescent in Situ Hybridization;Gene Activation;Gene Expression;gene induction;Genes;Genetic Transcription;Grant;Hexamethylene Bisacetamide;Hippocampus;Hour;Human;Immediate-Early Genes;immunocytochemistry;Impairment;In Situ Hybridization;inducible gene expression;Intellectual functioning disability;K-Series Research Career Programs;knock-down;Learning;Length;Link;Mammals;Memory;Mentors;Messenger RNA;Molecular;Mood Disorders;Mus;Neurons;novel;Nuclear;Operative Surgical Procedures;overexpression;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Positive Transcriptional Elongation Factor B;Process;Processed Genes;promoter;protein complex;Protein Dephosphorylation;Proteins;Refractory;Regulation;Research Support;response;RNA;RNA Polymerase II;Role;Schedule;Signal Pathway;Signal Transduction;skills;Stimulus;Testing;therapeutic target;Time;timeline;Training;Transcript;Transcription Elongation;Transcription Initiation;Transcriptional Regulation;Translations;Writing

PROJECT_TITLE: Molecular Regulation of a Transcriptionally Poised State in Neurons and its Role in Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The type IV collagens are fundamental basement membranes components. They are encoded by 6 genes (COL4A1-COL4A6) that form three heterotrimers – a1a1a2(IV), a3a4a5(IV), and a5a5a6(IV). Mutations in five of the six genes cause life threatening nephropathies. We will develop novel genetic tools enabling unprecedented ability to study their deposition, turnover, and biochemical properties.

PI_NAMEs: GOULD, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Address;Adult;Affinity Chromatography;Aging;Alleles;Apoptosis;Basement membrane;Binding;Biochemical;Biological Process;Biology;biophysical properties;Blood - brain barrier anatomy;Calmodulin;cell behavior;cell type;Cells;Characteristics;Chronic;COL4A6 gene;Collagen;Collagen Type IV;conditional knockout;Cryopreservation;Deposition;Development;Disease;Disease Pathway;Distal;Embryonic Development;Extracellular Matrix;Filtration;Fluorescence Microscopy;Genes;Genetic;Genetic Recombination;glomerular basement membrane;Glomerular capsule structure;glomerular function;Goals;Hereditary nephritis;Homeostasis;Impairment;in vivo;inducible Cre;Inherited;insight;Kidney;Kidney Diseases;Knock-out;Label;Life;Mediating;Methods;migration;Molecular;monomer;mouse model;Mouse Strains;Mus;Mutation;novel;Organ;Organogenesis;Pathologic;Pathology;Peptides;Physiological;Placenta;postnatal;Proliferating;Property;Protein Isoforms;Proteins;Pulmonary alveolar structure;Research;Research Design;Research Personnel;Resources;Role;Signal Transduction;spatiotemporal;sperm cell;Tamoxifen;Testing;Time;Tissues;tool;transcriptomics;Validation;Visualization

PROJECT_TITLE: Development of novel genetic tools for the study of type IV collagens

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The Maui wildfires of 2023 had devastating consequences, exacerbating pre-existing health and socioeconomic disparities among the island's diverse residents. Our research endeavors to comprehensively examine the multifaceted impacts of this disaster, collecting both social and biological data. This study aims to guide informed recovery strategies, highlight health implications, and emphasize the need for resilience planning in the face of potential future calamities.

PI_NAMEs: JUAREZ, RUBEN  (contact);MAUNAKEA, ALIKA KEOLAOKALANI

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Affect;Air;American;Annual Reports;Area;Aromatic Polycyclic Hydrocarbons;Asian Americans;binge drinking;Biological;Biological Markers;Blood Pressure;Body mass index;cardiovascular health;Cells;Chronic Disease;Classification;climate change;climate impact;cohort;Cohort Studies;Collection;Communities;Community Health;community organizations;Data;Diabetes Mellitus;Diet;Disasters;dissemination strategy;Educational Status;Environmental Hazards;Ethnic Origin;Ethnic Population;evidence base;Exposure to;Feces;Filipino;Filipino American;Food;Foundations;Future;Geography;Government;ground water;Guidelines;Hawaii;hazard;Health;Health behavior and outcomes;health data;health disparity;health economics;health inequalities;Health Status;Healthcare;Heavy Metals;High Prevalence;Hispanic;Hispanic Populations;Housing;Individual;Inequity;insight;Institution;Intervention;Island;Knowledge;Latino Population;longitudinal analysis;Measures;Mental Health;Minority Groups;minority health;Modeling;Monitor;multi-ethnic;multidisciplinary;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Natural Disasters;Neighborhoods;Not Hispanic or Latino;Obesity;Occupations;Outcome;Participant;Particulate Matter;Personal Satisfaction;physical conditioning;Physical environment;Policies;Policy Maker;Policy Making;Population;Population Heterogeneity;Poverty;Prevalence;promote resilience;psychologic;Public Health;Race;Readiness;Recommendation;Recovery;Recovery Support;recruit;Research;Research Design;resilience;Resource Allocation;Resources;respiratory health;Risk Factors;Saliva;Sampling;sedentary lifestyle;sex;Signal Transduction;Smoke;Smoking;smoking cessation;social;social media;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;Spirometry;Stress;Subgroup;Surveys;Time;tool;toxicant;Toxicant exposure;Trust;Urine;Visit;volatile organic compound;web site;Wildfire

PROJECT_TITLE: The Maui Wildfire Exposure Cohort Study on Community Health and Resilience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-H (57)]


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PI_NAMEs: D'AMICO, ELIZABETH J. (contact);JOHNSON, CARRIE

PROGRAM_OFFICER_NAME: SMITH, JACLYN D'ANNE

PROJECT_TERMS: Acceleration;Acute Pain;Address;Adult;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;animation;Applications Grants;Award;behavioral and social science;behavioral health;California;Caring;chronic pain;Clinical Trials;Collaborations;Communication;Communities;community based participatory research;community based research;community engaged research;community engagement;community organizations;community partners;Consultations;County;Creativeness;Cultural Sensitivity;Dancing;Data;Data Analyses;Data Collection;data dissemination;data management;Decision Making;design;Development;Discipline;Documentation;Educational Curriculum;effective intervention;Elderly;Ensure;Epidemic;Epidemiology;Ethics;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;Eye;Face;Family;Film;flexibility;Focus Groups;Foundations;Friends;Funding;Geography;Goals;Grant;Health;Health Promotion;Helping to End Addiction Long-term;Improve Access;improved;Indigenous;Information Dissemination;innovation;insight;Intervention;Interview;Knowledge;Language;Lead;Learning;Letters;Linguistics;Location;Logistics;Love;Mediation;member;Mental Health;Methodology;Methods;Modeling;Motivation;motivational enhancement therapy;Native American community;Native American population;Native Americans;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Overdose;Pain;Pain management;Parents;participant retention;patient engagement;Patient Recruitments;Patient-Focused Outcomes;peer;peer support;Personal Satisfaction;Persons;Pharmaceutical Preparations;Platinum;Policy Maker;Population;Positioning Attribute;Productivity;Program Sustainability;programs;Protocols documentation;Public Health;public health emergency;Publications;Publishing;randomized, clinical trials;Randomized, Controlled Trials;Readability;Readiness;Recovery;recruit;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Reservations;Resources;Science;Scientist;Secure;Services;Site;Sleep;sleep health;Social Impacts;social network intervention;Speed;statistics;stimulant use disorder;substance use;success;Suicide prevention;Surveys;therapy design;Thinking;Time;tool;Training;Trauma;Tribes;unethical;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;urban Native American;urban setting;video chat;Voice;web site;Wellness Center;Work;Writing;Youth

PROJECT_TITLE: Partnering to Achieve Wellness for Native Americans through Indigenous Knowledge (PAWNIK)

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Kidney Disease;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE To fuel malignant proliferation, cancer cells require a continuous supply of metabolic building blocks, and yet some tumors arise following genetic disruption of critical metabolic pathways, including the tricarboxylic acid (TCA) cycle. How tumors cope with impaired TCA cycle activity—and whether the pathways that compensate for TCA cycle disruption can be targeted—remains largely unknown. The goal of this proposal is to test the hypothesis that ATP citrate lyase (ACL) activity compensates for impaired TCA cycle function in renal cell carcinoma and to determine whether targeting alternative metabolic pathways provides a novel strategy to treat a subset of tumors with defective TCA cycle function.

PI_NAMEs: XIE, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adopted;Anabolism;Aspartate;ATP Citrate (pro-S)-Lyase;cancer cell;Cancer cell line;cancer predisposition;career;cell growth;Cell Line;Cell Proliferation;Cell Survival;cell type;Cells;Citric Acid Cycle;Clear cell renal cell carcinoma;clinical training;Compensation;coping;Critical Pathways;Data;Dependence;Development;Effectiveness;Enzymes;experimental study;Fumarate Hydratase;Fumarate Hydratase Deficiency;Functional disorder;Generations;Genes;Genetic;Germ Lines;Germ-Line Mutation;Goals;Growth;Human;Hyperactivity;Hypoxia;Hypoxia Inducible Factor;Impairment;In Vitro;in vivo;Inherited;inhibitor;Laboratories;Lead;Light;loss of function mutation;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Mediating;Memorial Sloan-Kettering Cancer Center;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;neoplastic cell;Neuroendocrine Tumors;novel strategies;nucleotide metabolism;Output;Oxaloacetates;Pathway interactions;Patients;pharmacologic;Physicians;Predisposition;Production;Proliferating;Protein Biosynthesis;pyruvate dehydrogenase;reconstitution;Renal Cell Carcinoma;Route;Scientist;Signal Transduction;Source;Succinate Dehydrogenase;Supporting Cell;Syndrome;targeted cancer therapy;Testing;Therapeutic;Tissues;tool;Training;tumor;tumor growth;tumor metabolism;Tumor Suppressor Proteins;tumor xenograft;VHL gene;Work

PROJECT_TITLE: Metabolic vulnerabilities in cancers with impaired TCA cycle activity


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Common chronic pain syndromes, such as fibromyalgia and temporomandibular disorder, constitute one of our nation’s most significant healthcare problems, yet are ineffectively treated because the underlying molecular mechanisms remain largely unknown. We hypothesize that these conditions are driven by catecholamine activation of beta-adrenergic receptor 3 and subsequent dysregulation in microRNA 374 which regulates the expression of genes important for pain and inflammation. Therefore, this proposal applies diverse methodologies in a clinically-relevant animal model in order to (1) define the relationship between beta-3 adrenergic receptor activation, microRNA 374, and complimentary mRNA expression with regards to cell type and sex, and (2) test the hypothesis that altered levels of miRNA 374 in mice directly contributes to pain.

PI_NAMEs: HERNANDEZ, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Agonist;American;Analgesics;Androgens;Animal Model;antagonist;Aromatase Inhibitors;Binding;Biological Assay;Career Mobility;Case/Control Studies;Catechol O-Methyltransferase;Catecholamines;Cell Line;cell type;Cells;Chronic;chronic pain;Chronic pain syndrome;Clinical;clinically relevant;collaborative environment;CRK gene;cytokine;Data;Development;Dose;Down-Regulation;enhancing factor;Environmental Risk Factor;Enzymes;Epigenetic Process;Estrogens;Etiology;Exhibits;Exposure to;Female;Fibromyalgia;Fostering;Functional disorder;Gene Expression;Genes;Genetic;genetic variant;Genotype;Gonadal Steroid Hormones;Healthcare;HIF1A gene;Immune;immune function;Immune response;Immune signaling;improved;In Vitro;in vivo;Incubated;Individual;Inflammation;Link;Luciferases;male;Measures;Mediating;Mediator;Messenger RNA;Metabolism;Methodology;Methods;MicroRNAs;Modeling;Molecular;mouse model;mRNA Expression;Mus;Nerve;Nervous System Physiology;Neuroglia;neuronal excitability;Neurons;Norepinephrine;novel;overexpression;Pain;pain behavior;Pain Measurement;Pathology;Patients;Peripheral;Persistent pain;pharmacologic;Plasma;Play;pre-clinical;prevent;Production;Proteins;Quality of life;Receptor Activation;Receptors, Adrenergic, beta-3;Regulation;Reporter;Reporting;Risk;RNA;Role;sex;Sex Differences;Signal Transduction;Site;Spinal Cord;Stress;Stressful Event;supportive environment;System;Techniques;Temporomandibular Joint Disorders;Testing;TGFBR2 gene;therapeutic miRNA;Tissues;Training;transcriptome sequencing;Universities;Untranslated RNA;Variant;Vehicle crash;Visualization;Work

PROJECT_TITLE: MicroRNA 374 as an Epigenetic Regulator of Chronic Pain


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE We have recently identified adenine as a key metabolite that regulates cardiac repair. However, the mechanisms of adenine generation and downstream effects are unknown. Using mouse models and analysis of GWAS, we investigate the molecular and genetic regulation of adenine generation and downstream effects in heart repair.

PI_NAMEs: DEB, ARJUN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Adenine;Adenosine;Anabolism;Animals;Apoptotic;Area;Attenuated;base;Biochemical;Biochemical Reaction;Cardiac;Cardiac Myocytes;cardiac repair;Cardiomyopathies;Cardiovascular system;causal variant;Cell Death;Cell membrane;Cell Physiology;Cells;Cicatrix;clinical investigation;Collaborations;Computational Biology;Consumption;CRISPR screen;CRISPR/Cas technology;Data;Data Set;Defect;Development;Dilatation - action;Diphosphates;ecto-nucleotidase;Enzymes;Etiology;experimental study;extracellular;Fibrosis;gain of function;gene-editing approach;Generations;Genes;Genetic;Genetic Engineering;genome wide association study;genome-wide;Goals;healing;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;hemodynamics;Human;human population genetics;humanized monoclonal antibodies;Impairment;Infarction;Inflammatory;Injury;Investments;ischemic injury;Journals;loss of function;LoxP-flanked allele;Medicine;Metabolic;Metabolism;metabolomics;Methionine;Molecular;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;novel;Nucleotidases;nucleotide metabolism;Orthologous Gene;Pathway interactions;pharmacologic;Pharmacologic Substance;phosphoric diester hydrolase;Phosphorylases;Physiological;Physiology;plasma cell membrane glycoprotein PC-1;Play;Population Genetics;Protein Engineering;Proteins;Purine Nucleosides;Pyrimidine;pyrophosphatase;Regulation;repaired;Research;response;response to injury;Rest;Role;Secondary to;Single Nucleotide Polymorphism;Suggestion;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Tissues;trait;Ventricular;Ventricular Remodeling;wound healing

PROJECT_TITLE: Adenine metabolism in cardiac repair

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: MEMPHIS

ORG_NAME: TAVO BIOTHERAPEUTICS, INC

ORG_STATE: TN

PHR: Because elevated intraocular pressure (IOP) and IOP fluctuations are the primary risk factors for loss of visual field in glaucoma, the current standard of care for adult-onset glaucoma includes treatment with IOP-lowering medications that are typically delivered topically as eye drops because of their ease of use and the ability for a patient to receive treatment from the comfort of their home. The requirement for multiple daily dosings along with associated eye irritation in addition to orbital and systemic side effects noted in available medications, collectively contribute to the low patient adherence documented by many eye care specialists. To directly address this unmet clinical need to increase patient adherence, within these SBIR Phase 1 studies, we will optimize and evaluate the IOP-lowering properties and safety of a subconjunctival biodegradable electrospun depot containing PRG.

PI_NAMEs: JOHNSON, DIANNA AMMONS (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;Adult;Affect;Agreement;Area;Beds;biocompatible polymer;biodegradable polymer;Biodistribution;biomaterial compatibility;Biomedical Engineering;Blindness;capsule;Caring;Clinical;cost efficient;Data;Deposition;design;Development;Dose;Drops;Drug Delivery Systems;drug distribution;Dryness;Emulsions;Engineering;experience;Eye;Eyedrops;Family;FDA approved;Film;Foreign Bodies;Formulation;Glaucoma;Goals;Grant;Home;innovation;irritation;Liquid substance;Manuals;Marketing;Methods;nanofiber;novel;Outcome Study;Patient Compliance;Patients;Performance;Pharmaceutical Preparations;Phase;phase 1 study;Physiologic Intraocular Pressure;Physiological;Polymers;Positioning Attribute;pregabalin;preservation;Process;Property;Proteins;Reproducibility;Research;response;Risk Factors;Safety;Self Administration;Shapes;side effect;Small Business Innovation Research Grant;Solid;Specialist;spheroids;standard of care;Surface;System;Tablets;Technology;Testing;Therapeutic;therapy development;tool;Topical application;Vision;Visual Fields

PROJECT_TITLE: Development of a novel depot delivery system for a glaucoma therapeutic


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Multiple myeloma constitutes 12-13% of hematologic malignancies in the US and is a significant problem in our aging veteran population, especially those exposed to Agent Orange. Nearly half of patients with myeloma have an associated kidney dysfunction and at least one large study found that reversibility of renal function was a more important prognostic factor than response to chemotherapy. The present application proposes to address gaps in knowledge in defining the role of immunoglobulin free light chains in the progression of kidney injury. The specific focus will be on the interaction of free light chains with the proximal tubule and the generation of kidney fibrosis in the setting of multiple myeloma. !

PI_NAMEs: SANDERS, PAUL W. (contact)

PROJECT_TERMS: Address;Affect;African American;agent orange;Aging;Binding;Cells;Cellular biology;chemotherapy;Chronic Kidney Failure;Clinical;clinical practice;clinically relevant;complementarity-determining region 3;Creatinine;Cyclization;Development;Disease;Distal;Elements;Environment;Epidemiology;Epithelial Cells;Epithelium;Epitopes;Event;Excision;experimental study;Exposure to;Generations;Glycoproteins;Goals;Growth Factor;Hematologic Neoplasms;High Prevalence;Hydrogen Peroxide;Hydrophobicity;Immunoglobulins;improved outcome;In Vitro;in vivo;in vivo Model;Incidence;Incubated;Inflammatory;Injury to Kidney;Interleukins;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;kidney fibrosis;Knowledge;Laboratories;Lesion;Light;Light Chain Deposition Disease;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;military veteran;Modernization;Molecular Weight;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;Nephrons;nephrotoxicity;novel;novel strategies;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Patients;Peptide Hydrolases;Peptides;Plasma Cells;Play;Predisposition;premalignant;Production;Prognosis;Prognostic Factor;Proteins;Proteolysis;Reaction;Recovery of Function;Renal function;Renal Replacement Therapy;Resistance;response;Rodent Model;Role;Series;Serum;Signal Transduction;Site;STAT1 protein;Structure;Therapeutic;therapy design;Time;Transforming Growth Factor beta;Tryptophan;Tubular formation;UMOD gene;Veterans;Work

PROJECT_TITLE: Low Molecular Weight Protein Nephrotoxicity


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: This bench-to-bedside pilot study evaluates the safety of a novel medical technology, LANT (Laser-Activated NanoTherapy), for treating a type of skin cancer called cutaneous squamous cell carcinoma (cSCC). Veterans have a high risk for this type of skin cancer due to extensive exposures during the line of duty to the sun and chemical warfare agents like Agent Blue and Lewisite. This project is of significant interest because Veterans with difficult-to-treat cancer facing poor clinical outcomes could greatly benefit from LANT. This new cancer treatment may address the unmet need for a local and minimally invasive alternative to radiation when surgery is not a viable option.

PI_NAMEs: GREEN, HADIYAH-NICOLE  (contact)

PROJECT_TERMS: 3D ultrasound;Address;Age;Appearance;Area;Arsenic;bench to bedside;Biodistribution;Biological;Biopsy;Burn injury;cancer therapy;Cell Death;Cell Death Induction;Cell Therapy;Cessation of life;Chemical Warfare Agents;Cicatrix;Clinical;comorbidity;Connective Tissue;Control Groups;Data;Dermis;design;Diagnosis;digital;Domestic Pig;Dose;effective therapy;Effectiveness;Ensure;Epidermis;Evaluation;Excision;first-in-human;Generations;Hematology;high risk;Histologic;Histology;Histopathology;Human;Image;immunosuppressed;In Vitro;in vivo;Individual;Inductively Coupled Plasma Mass Spectrometry;Infection;Injections;Injury;innovation;insight;Institutional Review Boards;interest;Lasers;lewisite;Local anesthesia;Malignant Neoplasms;Measures;Medical Technology;melanocyte;Melanoma;Methods;micrography;minimally invasive;Modeling;Mohs Surgery;Morphology;mouse model;Mus;nanoGold;nanoparticle;nanorod;nanotherapy;Neoplasm Metastasis;new technology;novel;Operative Surgical Procedures;Outcome;Output;Pain;pharmacokinetics and pharmacodynamics;Photography;Pilot Projects;porcine model;Process;Prognosis;Publications;Publishing;Radiation;recruit;Recurrence;Research Design;Risk;Safety;safety assessment;Serology;side effect;Site;Skin;Skin Cancer;skin healing;skin squamous cell carcinoma;Squamous cell carcinoma;standard of care;subcutaneous;Subcutaneous Tissue;Surface;Technology;Testing;the sun;therapeutically effective;therapy outcome;Thermal Ablation Therapy;Thermography;Time;Tissues;Toxic effect;Translating;tumor;Ulcer;Ultrasonography;Ultraviolet Rays;United States;Veterans;Work;Xenograft procedure

PROJECT_TITLE: Safety Assessment of Laser Activated NanoTherapy (LANT) as a Potential Treatment for Veterans with Cutaneous Squamous Cell Carcinomas


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Patients with post-traumatic stress disorder (PTSD) exhibit co-morbid alcohol use disorder (AUD) at far greater rates than the general population, but we have no effective therapies for these diseases when they present simultaneously. In Veteran populations the relationship between AUD and PTSD is even more prevalent as 63% of Veterans diagnosed with AUD are co-diagnosed with PTSD. Fibroblast growth factor 21 (FGF21) is a secreted endocrine molecule that signals to the brain to decrease alcohol consumption and genetic variation in genes encoding FGF21 and its receptor, β-klotho, are associated with increased alcohol consumption in humans. More recently we have observed that FGF21 also increases fear memory following chronic alcohol consumption in mice and propose to investigate how FGF21 signaling in the brain influences both alcohol consumption and fear to provide new therapeutic targets to treat Veterans suffering from both PTSD and AUD.

PI_NAMEs: FLIPPO, KYLE HARRINGTON (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;alcohol comorbidity;Alcohol consumption;alcohol response;alcohol use disorder;Alcohols;Amygdaloid structure;Brain;Calcium;career;career development;Chronic;chronic alcohol ingestion;Clinical;conditioned fear;Cues;Data;design;Development Plans;Diagnosis;Disease;effective therapy;Emotional;Endocrine;Exhibits;experience;experimental study;Extinction;Faculty;fear memory;Feedback;fibroblast growth factor 21;Fright;Funding;General Population;Genes;Genetic Variation;genomic locus;Goals;Healthcare;Heavy Drinking;Homeostasis;Hormones;Human;Image;Impairment;improved;in vivo calcium imaging;Knowledge;Leadership;Learning;Liver;Medical Records;Mentors;Mentorship;Metabolic;military veteran;Mus;neural;Neural Pathways;Neurons;new therapeutic target;Nucleus Accumbens;optogenetics;Patients;Population;Population Projection;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;preference;Property;receptor;Regulation;Research;Research Personnel;response;Rewards;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;symposium;Symptoms;Techniques;tenure track;Training;United States;Veterans;Writing

PROJECT_TITLE: Endocrine regulation of alcohol consumption and fear learning


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The proposed research is relevant to Veteran health because it focuses on innovative ways to electronically measure frailty and multimorbidity in older Veterans with multiple myeloma using data from the integrated national VA health system. This work will lead to tools for VA oncologists to identify age-related vulnerabilities that can inform decision making regarding intensity and type of initial treatment for myeloma. Moreover, these electronic measures will allow VA investigators to study the safety and effectiveness of current and future myeloma treatment regimens as they are applied to older Veterans with frailty and multimorbidity. The proposed research seeks to combine geriatric measures with cancer-specific measures toward better individualizing care for older Veterans, intersecting the missions of the VA Geriatrics Research Education and Clinical Centers (GRECC) and the National VA Precision Oncology Program.

PI_NAMEs: DUMONTIER, CLARK WILLIAM (contact)

PROJECT_TITLE: Integration of Geriatric Measures Alongside Disease-Based Measures to Advance Precision Oncology for Older Veterans with Multiple Myeloma


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Mutational processes that underlie human cancer leave mutational signatures identifiable by whole genome sequencing. Precision Oncology aims to target these underlying mutational processes. Seminal work by the Sanger Institute has identified mutational patterns, including single and doublet base pair substitutions, indels, and copy number alterations, and structural variants, that are indicative of defects in DNA replication and repair, mutagen exposures, and enzymatic modification of DNA. These mutational signatures could be prognostic or predictive. Determining if these mutational signatures predict treatment response in Veterans could provide expanded therapeutic indications for larger numbers of Veterans. At a fundamental level, whether the mutational signatures identified in civilian tumors are found in tumors from United States Veterans and whether novel signatures might develop due to war-time exposures is unknown. Identification of these novel mutational signatures may reveal new therapeutic targets and inform preventative measures to reduce exposure risk.

PI_NAMEs: KELLEY, MICHAEL J;MAXWELL, KARA N (contact);PYARAJAN, SAIJU

PROJECT_TERMS: Aneuploidy;base;Base Pairing;Biological Markers;BRAF gene;brca gene;cancer genome;cancer genomics;Cancer Patient;carcinogenicity;Caring;Catalogs;Characteristics;Chromosomal Instability;chromothripsis;Clinical;clinical sequencing;clinical translation;Clinical Trials;cohort;Copy Number Polymorphism;Coupling;Data;data repository;Databases;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Modification Process;DNA Repair;DNA Repair Disorder;DNA Sequence Alteration;Environmental Exposure;Epidermal Growth Factor Receptor;European;Event;exome sequencing;Fingerprint;Future;gastrointestinal;Gastrointestinal tract structure;Genetic;Genitourinary system;Genome;genome sequencing;Genomics;homologous recombination;Human;improved;Individual;insertion/deletion mutation;Knowledge;Loss of Heterozygosity;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Microsatellite Instability;military veteran;Minority;Modeling;Molecular;Mutagens;Mutation;National Cancer Institute;new therapeutic target;novel;Oncogenic;oncology program;Pathologic;Pathway interactions;Patient Selection;Patients;Pattern;Phenotype;precision oncology;Prediction of Response to Therapy;predictive marker;predictive signature;Preventive measure;Process;prognostic;prognostication;programs;Prostatic Neoplasms;Publishing;Resources;Risk;Sampling;Screening for cancer;Selection for Treatments;Seminal;Services;Single base substitution;Specimen;standard of care;success;targeted sequencing;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;time use;Tissues;treatment response;tumor;tumor DNA;tumor growth;Tumor Markers;United Kingdom;United States;United States Department of Veterans Affairs;Urothelium;Variant;Veterans;whole genome;Work

PROJECT_TITLE: Mutational processes underlying tumor development in United States Veterans


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Rare Diseases;Wound Healing and Care

PHR: Cell adhesion structures called desmosomes provide tissues with mechanical stability and coordinate many aspects of cell function. Disruption of desmosomes leads to blistering diseases of the skin and cardiomyopathies. Our work will increase our understanding of how desmosomes organize the cell and localize and control translational pathways. These studies are expected to yield novel insights into how desmosomes and skin respond to both wounding and autoimmune blistering diseases.

PI_NAMEs: LECHLER, TERRY H (contact)

PROJECT_TERMS: Acute;Address;Adhesions;Affect;Amino Acyl-tRNA Synthetases;Antibodies;Antibody Therapy;Autoimmune;Autoimmune Diseases;Bacterial Infections;Binding;Biology;Biotinylation;Bulla;Cardiomyopathies;Cell Adhesion;cell cortex;Cell Physiology;Cell-Cell Adhesion;Cells;Clinical;Cytoskeletal Filaments;Cytoskeleton;Data;Defect;Desmosomes;Disease;Dysplasia;Elements;Elongation Factor;Epidermis;Epithelium;Gene Expression;Genetic Diseases;Goals;Heart;imaging approach;insight;Intermediate Filaments;keratinocyte;Life;Link;Mechanics;Mediating;Messenger RNA;MicroRNAs;Mitochondria;Mitochondrial Proteins;Molecular;mRNA Translation;novel;Pathogenicity;Pathology;Pathway interactions;Pemphigus;Pemphigus Vulgaris;Peptide Initiation Factors;phosphoproteomics;Phosphorylation;Physiology;posttranscriptional;Process;Proteins;Proteomics;recruit;response;Ribosomal Proteins;RNA-Induced Silencing Complex;Role;sensor;Signal Transduction;single molecule;Site;Skin;skin disorder;Structure;Tissues;Transcript;Transducers;Translational Regulation;Translations;Work;wound;wound healing

PROJECT_TITLE: Roles for desmsomes in mRNA localization and translational regulation


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Palliative Care;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: Project Narrative This Cycle 2 renewal proposal directly addresses the public health concerns regarding health equity for underserved and vulnerable populations such as rural children and adolescents with serious illness. Its results will represent a continuation of our Cycle 1 evaluation of a health policy intervention on pediatric end-of-life outcomes and will provide evidence on the effectiveness of a policy modification (i.e., transitional care regulations) to improve functioning, resource use, and spending among children and adolescents receiving hospice and medical care simultaneously.

PI_NAMEs: LINDLEY, LISA C. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Admission activity;Adolescent;adverse outcome;Affect;Affordable Care Act;Ambulatory Care;Applications Grants;Area;Back;beneficiary;care fragmentation;care outcomes;Caring;Cessation of life;Characteristics;Child;Child Health;Child health care;Child health equity;Childhood;Cognitive;cohort;Communities;Complex;cost;County;Data;Data Science;Data Set;Disadvantaged;Disparity population;Effectiveness;Eligibility Determination;Emergency department visit;Emotional;end of life;end of life care;end of life outcomes;Environment;Evaluation;Expenditure;Family;functional improvement;Funding;Goals;Health;Health Benefit;health care availability;health care settings;health equity;health management;Health Policy;Health Priorities;Health Professional;Healthcare;healthcare burden;Healthcare Systems;high risk;hospice environment;hospice utilization;Impairment;improved;Individual;innovation;Inpatients;insight;Intervention;Knowledge;Life;Link;machine learning method;Mediating;Mediation;Medicaid;Medical;Modeling;Modification;multidisciplinary;Natural experiment;Neighborhoods;Nurses;Outcome;Palliative Care;Pathway interactions;Pharmacists;Physicians;Policies;Population;Primary Care;Productivity;programs;Provider;Public Health;Qualifying;Regulation;Reporting;Research;Resources;response;Risk;Rural;rural area;Rural Community;rural health disparities;rural healthcare;rural underserved;rurality;Science;Services;social determinants;social health determinants;Specialist;Statistical Data Interpretation;Strategic Planning;Subgroup;supervised learning;System;Team Nursing;Testing;Time;Travel;Underserved Population;unsupervised learning;Vulnerable Populations;Work

PROJECT_TITLE: Effectiveness of Concurrent Care to Improve Pediatric and Family Outcomes at End of Life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Negative affective disturbances, including stress, anxiety, and depression, are characteristic of alcohol abstinence, and a leading cause of relapse. A greater understanding of the complex neural circuitry regulating the disease state will lead to better diagnostic tools and treatment options for abstinence-induced negative affect. This project will investigate the functional state of the insular cortex-bed nucleus of the stria terminalis neural pathway in alcohol abstinence, two regions implicated in alcohol use disorders and negative affect.

PI_NAMEs: CENTANNI, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;addiction;Affect;Affective;affective disturbance;Affective Symptoms;alcohol abstinence;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol seeking behavior;alcohol use disorder;Alcoholism;Amygdaloid structure;Anterior;anti-depressive agents;Anxiety;Anxiety Disorders;associated symptom;Automobile Driving;Award;Awareness;Behavior;binge drinking;Brain;Brain imaging;Calcium;career;career development;Cell Nucleus;cell type;Characteristics;Chronic;Chronic Phase;cognitive control;comorbidity;Complex;Coupled;craving;Data;designer receptors exclusively activated by designer drugs;Diagnostic;diagnostic tool;Disease;drinking;Electrophysiology (science);Emotional;Exhibits;Family;feeding;Fiber;Financial Hardship;Food;Genetic;genetic approach;genetic manipulation;Genetic Recombination;Genetic Techniques;Goals;Health;Heterogeneity;hindbrain;Human;Hyperactivity;in vivo;Individual;Insula of Reil;Interneurons;Link;Major Depressive Disorder;Mental Depression;Mental disorders;Mentors;Midbrain structure;Motivation;mouse model;Mus;negative affect;Negative Reinforcements;neural;neural circuit;Neural Pathways;neuroadaptation;neuroimaging;Neurons;novel;Output;Pathway interactions;Patients;Pattern;Phase;Photometry;Physiological;Play;Post-Traumatic Stress Disorders;Predisposition;problem drinker;prophylactic;Regulation;Relapse;Reporting;Research;Role;Sensory;Severities;Severity of illness;side effect;social;Somatosensory Cortex;Source;Stress;stress related disorder;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Symptoms;Synapses;Testing;Thalamic structure;Therapeutic;therapeutic target;Time;Training;Viral;Virus;virus genetics;Withdrawal;Work

PROJECT_TITLE: Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Chronic Pain;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Methamphetamine;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HELENA

ORG_NAME: MONTANA CONSORTIUM FOR URBAN INDIAN HEALTH

ORG_STATE: MT

PI_NAMEs: GREEN, BRANDN  (contact)

PROJECT_TERMS: Acute;Address;Age;Alaska Native;barrier to care;base;behavioral health;care delivery;chronic pain;Client;Clinic;Clinical Data;Collaborations;Communities;Community Health Aides;community organizations;Country;County;culturally appropriate intervention;Data;Data Analyses;Data Collection;Data Reporting;Death Rate;Dedications;Disease;Disparity;Education;efficacy evaluation;Ensure;Environment;Ethnic Population;evidence base;Evidence based intervention;Evidence based program;experience;Fatality rate;Focus Groups;Foundations;Funding;Funding Agency;Funding Opportunities;Future;Gender;Geography;Goals;Government;Grant;healing;Health;health care availability;health inequalities;Health Services Accessibility;Healthcare;Helping to End Addiction Long-term;heroin use;high risk;High School Student;Home;implementation framework;implementation research;implementation science;Improve Access;improved;Indian reservation;Individual;insight;Intervention;Interview;Maps;Mental Health;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Methodology;Methods;Minority Groups;misuse of prescription only drugs;Modality;Modeling;Modification;Monitor;Montana;Native American population;Native Americans;Nonprofit Organizations;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Pain;Pain management;patient population;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phase;Population;population health;Positioning Attribute;Practice Management;prevent;process evaluation;programs;racial population;Recovery;Reporting;Research;Research Methodology;research study;Research Support;Reservations;residence;Rural;Service delivery model;Silver;Site;Stimulant;stimulant use;Study models;substance use;Substance Use Disorder;substance use treatment;surveillance data;Target Populations;Time;Treatment Efficacy;tribal lands;tribal Nation;Tribes;United States National Institutes of Health;urban area;Urban Health;urban Native American;urban setting;Work;Youth

PROJECT_TITLE: Promoting Wellness among Native Americans in Urban Areas


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: NARRATIVE Despite the dramatic health inequities faced by sexual and gender minority (SGM) individuals, there are a dearth of training opportunities focused on SGM health in general, and especially in the Deep South. AdvanceSGM is committed to training the next generation of diverse researchers in the risks and resiliencies of SGM populations and providing them with the skills needed to address SGM health inequities. Over 5 years, we will train 15 predoctoral students in both the didactic and experiential skills needed to lead a successful research career in SGM health.

PI_NAMEs: KAY, EMMA SOPHIA;MACCARTHY, SARAH  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Health;Research

PROJECT_TITLE: ADVANCE SGM Health for Research Diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative New drugs for Alzheimer's and related dementias (ADRD) show potential value, but their optimal use remains uncertain due to risks and modest efficacy. Traditional value assessment methods do not fully capture the diverse user-experiences; therefore, we will survey diverse older Americans to elicit their preferences and risk attitudes towards new ADRD medications to inform an innovative microsimulation model. This model will help us to better understand the value of new ADRD medications and help ensure equitable use.

PI_NAMEs: DRABO, EMMANUEL FULGENCE;SEGAL, JODI B. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adoption;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-42;Amyloid beta-Protein;Antibodies;Attitude;Behavioral;Calibration;Clinical;Cognitive;cognitive interview;Cohort Studies;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;cost of dementia;Data;Decision Making;Dementia;design;Disadvantaged;Disease;Disparity population;economic evaluation;Emotional;Ensure;Epitopes;Equity;ethnic minority;Ethnic Population;experience;experimental study;Face;Family;Focus Groups;Happiness;Health;health care availability;health care disparity;health economics;health equity;Individual;Inequity;innovation;instrument;Insurance Carriers;interest;Learning;Link;Literature;Medicare;Medicare claim;Memory;Methods;mild cognitive impairment;Modeling;models and simulation;novel;novel therapeutics;older adult;Online Systems;Outcome;Participant;patient population;Patient Representative;Patient Self-Report;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;pilot test;Population;preference;Price;Process;Production;Proteins;Publishing;racial minority;racial population;Resources;response;Risk;Risk Adjustment;Sampling;Services;Severity of illness;side effect;social;Spanish;standard of care;Surveys;tau-1;tool;trend;Uncertainty;Uninsured Medical Expense;Work

PROJECT_TITLE: Using the generalized risk-adjusted cost-effectiveness (GRACE) model to advance health equity in use of novel treatments for Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M4)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Glioblastoma is a very aggressive tumor of the Central Nervous System that responds poorly to conventional treatments and develops resistance to chemo- and radiotherapy. In this project we will investigate a novel mechanism that contributes to tumor cell survival and resistance to radiation; we will also develop novel agents to disrupt this mechanism and make glioblastoma more sensitive to radiotherapy. Our research will identify effective strategies to weaken the tumor, contributing to more effective treatments for patients with malignant brain cancers.

PI_NAMEs: VIAPIANO, MARIANO SEBASTIAN (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Agreement;Binding;Brain;cancer recurrence;cancer type;Carrier Proteins;Cell Physiology;Cell Survival;Cells;Cellular Stress;Central Nervous System Neoplasms;chemoradiation;chemotherapy;Clinical;Compensation;conventional therapy;cullin-3;Data;data modeling;design;DLG1 gene;DNA Damage;DNA Repair;Dominant-Negative Mutation;effective therapy;Engineering;Environment;Enzymes;Excision;expectation;Family;Family member;Genetic;Glioblastoma;Glioma;Goals;Growth;Homologous Gene;Homologous Protein;improved;In Vitro;in vivo;Individual;intracellular protein transport;Invaded;Lead;Location;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Medicine;member;Modeling;Molecular;molecular modeling;Molecular Target;neoplastic cell;neural;New Agents;novel;novel strategies;Operative Surgical Procedures;organizational structure;Organoids;Pathway interactions;Patients;Penetration;Peptides;Phenotype;Population;Population Heterogeneity;Prognosis;Protein Binding Domain;Proteins;public health relevance;Publishing;Radiation;radiation effect;radiation resistance;Radiation therapy;radioresistant;Radiosensitization;real time monitoring;Real-Time Systems;Regulation;Reporter;Research;resilience;Resistance;Resistance development;resistance mechanism;Scaffolding Protein;SHH gene;Signal Transduction;Solid Neoplasm;standard care;stem cell population;stem cells;stem-like cell;stemness;success;Survival Rate;synergism;Tertiary Protein Structure;Testing;Therapeutic;therapy resistant;tumor;Tumor Stem Cells;ubiquitin ligase;Work;x-ray irradiation

PROJECT_TITLE: Targeting scaffolding proteins to disrupt radioresistance in glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Mental Health;Pediatric;Unintentional Childhood Injury

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Teens with Attention-Deficit/Hyperactivity Disorder (ADHD) have high rates of negative driving outcomes, including motor vehicle crashes, which may be caused by visual inattention (i.e., looking away from the roadway to perform secondary tasks). A driver training program that effectively trains teens to reduce instances of looking away from the roadway and reduces crash rates will be converted to an immersive virtual reality platform in order to increase adoption and implementation. The relative effectiveness and cost effectiveness of the immersive virtual reality version of the driver training will be assessed.

PI_NAMEs: EPSTEIN, JEFF N. (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Address;Adopted;Adoption;Attention;Attention deficit hyperactivity disorder;Automobile Driving;base;Cause of Death;Cessation of life;comparison intervention;Complex;Computer software;Control Groups;cost;Cost Analysis;cost effective;cost effectiveness;cost outcomes;Data;driving performance;driving skills;Education;Effectiveness;effectiveness/implementation design;effectiveness/implementation study;efficacious intervention;efficacy evaluation;Event;Eye;Goggles;high risk population;Hybrids;implementation barriers;implementation outcomes;implementation science;improved;inattention;Injury;interest;Intervention;Learning;Length;LGALS3BP gene;Occupational Therapy;Outcome;Outpatients;parent grant;Parents;Positioning Attribute;pragmatic implementation;prevent;primary outcome;programs;Public Health;Publications;Publishing;Pythons;Randomized;Randomized, Controlled Trials;relative cost;relative effectiveness;Reporting;Research;Research Project Grants;Risk;Schools;secondary outcome;simulation;Site;teen drivers;teen driving;Teenagers;Testing;Training;Training Programs;Translating;Vehicle crash;virtual reality environment;Visual;visual tracking

PROJECT_TITLE: Improving ADHD Teen Driving

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE In this secondary data analysis proposal, we will address critical and timely questions about effects of social inequality on the brain and on substance use. We leverage existing datasets from the Adolescent Brain Cognitive Development (ABCD) study and the Minnesota Center for Twin and Family Research (MCTFR) to identify neurobehavioral deviations linking childhood socioeconomic disadvantage and substance use trajectories in adolescence and adulthood. Identifying individuals and families at the greatest risk for problematic substance use trajectories informs development of the most targeted prevention and intervention efforts possible for substance misuse and use disorder.

PI_NAMEs: WILSON, SYLIA  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Brain;Child;Childhood;cognitive development;cohort;Communities;cost effective;COVID-19;COVID-19 pandemic;Data Analyses;Data Set;Development;disadvantaged background;Disadvantaged minority;Discrimination;Economic Factors;Education;ethnic minority;Ethnic Origin;experience;Family;Family Research;Functional Magnetic Resonance Imaging;Household;Income;indexing;Individual;Inequality;Informal Social Control;Intervention;Legal system;Link;marginalization;Measurable;Mediating;Minnesota;minority children;multimodality;neurobehavioral;Neurocognition;Neurocognitive;Occupations;Participant;Performance;Population;Prevention;prospective;Public Health;Quasi-experiment;Race;racial minority;Research;Resources;Risk;Sampling;social disparities;social factors;socioeconomic disadvantage;Socioeconomic Status;stressor;Structure;substance misuse;substance use;Substance Use Disorder;Time;Twin Multiple Birth;United States

PROJECT_TITLE: Leveraging quasi-experimental methods to examine the longitudinal relations among legal system exposure, substance use, neurocognition, and education


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Heart Disease;Lung;Neurosciences;Prevention;Sleep Research

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Sleep is known to relate to general health but the effect of abnormal sleep on cardiac aging is yet to be fully determined. This proposal will take advantage of the longitudinal measure of sleep pathology in the Korean Genome and Epidemiology Study, a well-characterized cohort, and assess its impact on cardiac aging over one decade. The outlined strategy will identify novel digital sleep biomarkers and provide new avenues for future intervention to reduce the burden of cardiovascular disease.

PI_NAMEs: LIN, HONGHUANG  (contact);THOMAS, ROBERT JOSEPH

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acceleration;Age;Aging;American Heart Association;Aorta;Apnea;Arousal;Arrhythmia;arterial stiffness;Atrial Fibrillation;Biological;biological age;Biological Markers;Blood Pressure;Cardiac;cardiac aging;Cardiac conduction system;Cardiac health;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cholesterol;Clinical;clinical biomarkers;clinical risk;cohort;Collection;Coupling;cytokine;Deterioration;digital;digital technology;Electrocardiogram;Electrophysiology (science);Enrollment;Epidemiology;epidemiology study;fasting glucose;Future;Genome;Goals;Health;Heart;Heart failure;heart function;heart preservation;Heart Rate;Home;Hour;Hypertension;Hypoxia;Impairment;improved;Inflammation;Intervention;Investigation;Knowledge;Koreans;Lead;Life;Life Style;Machine Learning;Measures;Medicine;mortality;Myocardial Infarction;Myocardium;novel;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Polysomnography;prevent;Questionnaires;Resolution;Resources;respiratory;response;Rest;Risk;Risk Factors;Sleep;sleep abnormalities;Sleep Apnea Syndromes;Sleep Deprivation;Sleep disturbances;sleep pattern;sleep quality;Sleeplessness;targeted treatment;Time;valvular insufficiency;valvular stenosis

PROJECT_TITLE: Sleep pathology and cardiac aging

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Rural Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Depression is a significant problem in care partners of people living with dementia; despite the expansion of options for accessing evidence-based treatments, most care partners of people living with dementia are not screened for depression and do not receive treatment. The objective of this project is to identify a screening method for depression that is feasible and acceptable to care partners and to adapt an innovative pathway to online evidence-based treatment for depression (iPath*D) as a means of increasing mental health literacy, screening rates and treatment access for care partners of people living with dementia. The results are expected to have a major positive impact by providing proof-of-principle for the use of an online pathway to evidence based treatment with the potential for reaching an unprecedented number of care partners who have unmet mental health needs.

PI_NAMEs: MISTLER, LISA A (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Assessment tool;barrier to care;behavioral health;behavioral impairment;Belief;Cancer Patient;care delivery;care seeking;career;Caregiver Burden;Caring;Clinic Visits;Clinical;clinically significant;Cognitive Therapy;Communication;community engagement;Computer software;Consolidated Framework for Implementation Research;Consultations;Cost Analysis;cost effectiveness;Data;Decision Aid;Dementia;Depression screen;depressive symptoms;design;Detection;Development;Diagnosis;digital;Ensure;Evaluation;Evidence based treatment;experience;Foundations;Future;future implementation;General Population;Goals;Grant;Guidelines;Health Care Visit;health literacy;Health Services Accessibility;Healthcare;help-seeking behavior;Impaired cognition;implementation evaluation;improved;Individual;individualized medicine;Informatics;innovation;Intervention;Interview;Knowledge;Location;Malignant Neoplasms;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Methods;model design;Modification;motivational enhancement therapy;multi-site trial;novel;older adult;open label;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patient Preferences;patient screening;Patients;Persons;physical conditioning;preference;Prevalence;Prevention;prototype;Psychiatrist;Psychosocial Assessment and Care;Quality of life;Recommendation;Recovery;recruit;Reporting;Research;Research Personnel;response;Risk;Rural;Rural Community;rural setting;screening;Screening for cancer;Service delivery model;shared decision making;Specialist;symptomatic improvement;System;systematic review;Testing;usability;user centered design;virtual;Visit

PROJECT_TITLE: Improving screening and access to treatment for depression in care partners of people living with dementia


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Rehabilitation;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Chronic pain induced by aromatase inhibitor therapy is a common and debilitating symptom impacting breast cancer survivors. The Enhanced Pain Coping in Cancer (EPIC) trial investigates a novel, scalable, neuroscience-based, non-pharmacological virtual intervention with potential to change the paradigm of pain clinical care for millions of breast cancer survivors with aromatase inhibitor-associated arthralgia.

PI_NAMEs: GARLAND, ERIC LEE;HANLEY, ADAM WESLEY;MAO, JUN J (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acceleration;Address;Adherence;Affect;Affective;affective neuroscience;Aftercare;American Society of Clinical Oncology;Analgesics;Anxiety;arm;Aromatase Inhibitors;Arthralgia;associated symptom;Behavior;Breast Cancer survivor;cancer pain;Cancer Pain Management;Cancer Survivor;Cancer Survivorship;Caring;chronic pain;chronic painful condition;Clinical;clinical care;Clinical Oncology;clinical pain;clinically significant;Cognitive;Collaborations;common symptom;common treatment;Constipation;conventional therapy;coping;COVID-19;debilitating symptom;Disease;Double Effect;Early Diagnosis;Eligibility Determination;Ensure;experience;fall risk;Fatigue;follow-up;Funding;Group Psychotherapy;Group Therapy;Guidelines;Health Care Costs;Height;Home;improved;inhibitor therapy;innovation;Integrative Medicine;Internal Medicine;Intervention;Intervention Trial;Investigation;Joints;Long-Term Survivors;loved ones;Malignant Neoplasms;Mediating;Methodology;mindfulness;mindfulness intervention;Modeling;mortality;multidisciplinary;Nausea;Neurosciences;non-cancer chronic pain;Non-Steroidal Anti-Inflammatory Agents;novel;Oncology;Opioid;Opioid Analgesics;opioid misuse;opioid mortality;opioid use;Overdose;Pain;Pain interference;Pain management;pain model;pain reduction;pain symptom;pandemic disease;Participant;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;physical impairment;Population;primary endpoint;primary outcome;Process;programs;Provider;psychological distress;Public Health;Publishing;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recovery;Reporting;Research;Rewards;secondary outcome;Sedation procedure;Severities;side effect;Site;skills;Societies;stress management;Survivors;symptomatic improvement;Symptoms;Testing;therapy development;Training;United States;United States National Institutes of Health;virtual;virtual delivery;virtual intervention;virtual platform;Work

PROJECT_TITLE: Enhanced Pain Coping in Cancer (EPIC)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This proposal will develop foundational computational tooling for integrating accurate long-read or short-read epigenetic data into a pan-genome reference, and processing epigenetic data that is contained within a pan- genome reference. Overall, this tooling will improve our understanding of the function of genetic variants within the pan-genome reference that are contributing to human disease through their impact on gene regulatory elements.

PI_NAMEs: STERGACHIS, ANDREW BEN (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Adopted;Awareness;Characteristics;Chromatin;Chromatin Fiber;Chromosome Mapping;Classification;Complex;computerized tools;contig;Cytosine;Data;Data Set;design;DNA sequencing;Elements;Epigenetic Process;epigenome;Fiber;Fire - disasters;Genes;Genetic;genetic analysis;genetic variant;genomic locus;Genomic Segment;Genomics;Graph;Haploidy;Haplotypes;human disease;human pangenome;improved;Individual;interest;Maps;Methods;Methylation;methylation pattern;Nucleosomes;operation;pan-genome;paralogous gene;Pattern;Performance;Positioning Attribute;Proteins;reference genome;Regulatory Element;Research;Research Personnel;Sampling;sequencing platform;single molecule;software development;supervised learning;Technology;tool;transcription factor;uptake;Work

PROJECT_TITLE: Tooling for accurately studying the epigenome along the human pangenome reference

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M2)]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PHR: Narrative: The cellular and molecular mechanisms driving cyst initiation are poorly understood. We have developed a new model using mouse genetics that will allow us to characterize this process in vivo with unprecedented detail.

PI_NAMEs: CEBRIAN LIGERO, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Ablation;Affect;Alleles;Animals;Automobile Driving;Autosomal Dominant Polycystic Kidney;cell behavior;Cell Death;Cell model;Cells;Child;Cisplatin;Clonal Expansion;collecting tubule structure;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Data Reporting;daughter cell;Development;Disease;Distal;Duct (organ) structure;Early treatment;Embryonic Development;Environment;Epithelial Cells;Epithelial cyst;Equilibrium;Event;Exposure to;Generations;Genetic;Genetic Diseases;Genetic Heterogeneity;Genetic Recombination;genome sequencing;Growth;Heterozygote;Hybrids;Hypertension;in vivo;Incidence;Individual;induced pluripotent stem cell;Inherited;Injury to Kidney;Kidney;kidney cell;Kidney Failure;Label;Lead;Life;Lithium Chloride;Live Birth;Loss of Heterozygosity;Mediating;Mediator;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Mutate;Mutation;Nature;Nephrons;Organoids;Pain;Patients;Pharmaceutical Preparations;Phenotype;PKD1 gene;postnatal;Predisposition;prevent;Process;Proliferating;Renal function;Role;Series;Source;Tamoxifen;Testing;Tubular formation;Visualization

PROJECT_TITLE: Cyst induction and growth in ADPKD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-L (91)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases;Sepsis

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) is a devastating illness with high mortality. Most studies have investigated inflammation in ARDS, although many people are prone to immune suppression with impaired ability to fight infections. We have discovered a new model that may explain immune suppression in ARDS that led us to propose characterizing a protein that restores immune function and discovered a compound that preserves immune function. This discovery fulfills an unmet need in this critical illness.

PI_NAMEs: MALLAMPALLI, RAMA K (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;antagonist;Anti-Inflammatory Agents;Bacterial Infections;Binding;Biological;C-terminal;Cartoons;Cell Death;Cessation of life;Clinical Trials;Coupled;Critical Illness;cytokine;Cytoprotection;Data;design;Disease;Effector Cell;Epithelial Cell Proliferation;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;Equilibrium;Exhibits;Experimental Models;Failure;fighting;Foundations;Functional disorder;gain of function;Gene Transfer;Genetic Transcription;Homeostasis;Host Defense;Human;Immune;immune function;Immune response;Immunity;Immunologic Stimulation;Immunological Models;immunoreactivity;Immunosuppression;Immunosuppressive Agents;Impaired wound healing;Impairment;Infection;Inflammation;Inflammatory;inhibitor;innate immune function;Innate Immune Response;Knockout Mice;Life;Link;loss of function;Lung;lung injury;Lymphocyte;Mediating;Modeling;Molecular;molecular modeling;Molecular Profiling;mortality;Mus;Natural Immunity;novel;opportunistic pathogen;Pathway interactions;Patients;Persons;pharmacologic;Pharmacotherapy;Phenotype;Pneumonia;pneumonia model;Pre-Clinical Model;preservation;Production;Prognosis;Property;protein degradation;Proteins;repaired;response;S-Phase Fraction;Sepsis;Severities;Site;small molecule;superinfection;System;Testing;Therapeutic;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: E3 Ligase-Mediated Immunosuppression in Acute Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Ewing Sarcoma (ES) is an aggressive tumor often leading to the death of children and adolescents, particularly when it spreads to distant bones. Unfortunately, bone metastases are also difficult to study, due to the lack of clinical samples and problems with reproducing their formation in animal models. Thus, the goal of our project is to test the utility of a bioengineered device that mimics the conditions that ES cells encounter during bone metastasis for studies aiming at identifying key drivers of this process that can become targets for novel therapies tailored for patients with bone metastases; an approach that can be later adapted to other cancers.

PI_NAMEs: ALIMPERTI, STELLA ;KITLINSKA, JOANNA B. (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Adolescent;Animal Model;Architecture;Biological;Biological Assay;Biology;Biomedical Engineering;bone;Bone Matrix;Bone Tissue;cancer type;candidate selection;Cell Line;Cell Separation;Cells;Cessation of life;Chemoresistance;Child;Chromosomal translocation;Clinical;CRISPR interference;CRISPR screen;Data;Devices;Diagnosis;Diploidy;Disease;Disease-Free Survival;Distant;Down-Regulation;Dropout;Endothelial Cells;Environment;Ewings sarcoma;EWS-FLI1 fusion protein;Extracellular Matrix;Extravasation;FLI1 gene;functional genomics;Future;Genes;Genomic approach;Genomics;Goals;Hydrostatic Pressure;Hypoxia;in vitro Model;in vivo;in vivo evaluation;individualized medicine;Invaded;Lesion;Malignant Childhood Neoplasm;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Lung;metastatic process;Microfluidics;Modeling;multidisciplinary;Names;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;normoxia;Osteoblasts;Osteoclasts;Osteosarcoma;Outcome;Oxygen;Pathway interactions;Patients;Polyploid Cells;Population;prevent;Primary Neoplasm;Process;Prognosis;Proliferating;Property;rapid testing;Relapse;Reporting;Research;Research Personnel;Sampling;shear stress;Stromal Cells;Testing;Therapeutic;Tissue Engineering;tool;transcription factor;tumor;Validation;Work;Xenograft Model

PROJECT_TITLE: 3D bioengineered microfluidic platform for research on Ewing sarcoma bone metastasis

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: Project Narrative: The overall objective of this study is to determine whether the application of a targeted resistance torque to the knee joint during overground walking will induce improvements in crouch gait in children with CP. Results from this study are expected to demonstrate the effect of error size and error variability on the motor learning of improved crouch gait in children with CP, which is likely to provide a strong scientific foundation whereby new intervention strategies can be developed to improve crouch gait in children with CP.

PI_NAMEs: WU, MING  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acceleration;Address;Adolescent;Ankle;arm paresis;Arthralgia;botulinum neurotoxin injection;Cerebral Palsy;Child;crouch gait;Data;Degenerative polyarthritis;Deterioration;Development;effective intervention;Excision;Exhibits;experience;Foundations;Gait;Gait abnormality;Generations;Goals;Growth;hamstring;Hip Joint;Hip region structure;improved;Injections;innovation;Intervention;Joints;kinematics;Knee;Knee joint;Left;Length;Lower Extremity;motor learning;Muscle;Operative Surgical Procedures;Outcome;Pathologic;Pattern;Pelvis;Phase;Posture;programs;Resistance;robot assistance;strength training;stroke survivor;Torque;treadmill;Walking

PROJECT_TITLE: Improving crouch gait in children with CP through error augmentation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE Sensory neurons use small antenna-like structures called cilia to detect and transmit external cues, and damage to these structures due to genetic or environmental causes leads to multiple disorders including loss of smell, vision, and hearing. We will use the nematode C. elegans as an experimental system in which to explore how cilia in neurons regenerate following injury in the adult, and identify the required molecules. Since cilia are formed by remarkably similar mechanisms across species, we expect that findings from this work will be broadly translatable to other organisms.

PI_NAMEs: SENGUPTA, PIALI  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Adult;Afferent Neurons;Animals;Anosmia;Automobile Driving;Axon;axon regeneration;Behavioral;Biology;Blindness;Caenorhabditis elegans;Calcium;CCAAT-Enhancer-Binding Proteins;Cell Surface Extensions;Cells;Characteristics;Chemicals;Chlamydomonas;Chlamydomonas reinhardtii;Cilia;ciliopathy;cilium biogenesis;Cilium Microtubule;Cues;Development;Disease;Environment;Enzymes;experimental study;Exposure to;Flagella;Foundations;Functional disorder;gene conservation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Green Algae;Growth;Hearing;hearing impairment;Homeostasis;Individual;Infection;Injury;insight;Investigation;Knowledge;Length;MAP Kinase Kinase Kinase;Mediating;Mediator;Microtubules;Monitor;Natural regeneration;Nematoda;Nervous System;neuron regeneration;Neurons;Organelles;Organism;Pathway interactions;Photoreceptors;Play;Predisposition;Property;Recovery;regeneration following injury;Regenerative pathway;response;restoration;Role;sensor;Sensory;Signal Transduction;Signaling Molecule;Stimulus;Structure;Supporting Cell;System;Testing;Therapeutic;trafficking;transcription factor;Transducers;transmission process;Up-Regulation;Virus Diseases;Vision;Work

PROJECT_TITLE: Mechanisms of chemosensory neuron cilia regeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The NIH Common Fund initiated Metabolomics Workbench – National Metabolomics Data Repository is a unique resource that provides houses and provides metabolomics data for the biomedical research community and serves as a one-stop-shop for metabolomics research. Given its unique status and its service as an invaluable resource for biomedical research, there is an imperative need for its continued maintenance and enhancement. This proposal deals with its continued maintenance with additional improvements and enhancements in the form of new query capabilities, additional discoverability through filtering with human subjects’ metadata, and making the data available on the cloud through extant and AI-ready formats.

PI_NAMEs: SUBRAMANIAM, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: annotation  system;Biological;Biomedical Research;biomedical resource;Blood;Body Fluids;Cell model;Cells;Classification;Clinical;Clinical Research;cohort;Cohort Studies;Communities;Companions;Complex;Computers;Country;Data;data access;Data Discovery;data harmonization;data infrastructure;data repository;data resource;Data Set;data submission;database structure;Databases;Deposition;Disease;Evolution;experience;Exploratory/Developmental Grant;Fast Healthcare Interoperability Resources;Feedback;Friends;Functional disorder;Funding;genetic makeup;genomic data;Genotype;Graph;graph database;Growth;Home;Human;human subject;improved;Infrastructure;Ingestion;International;interoperability;knowledge graph;large scale data;Learning;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Metabolic;metabolic phenotype;metabolome;metabolomics;metabolomics resource;Metadata;Methods;Modeling;Motivation;outreach;Phenotype;Physiology;Process;relational database;repository;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scheme;Services;skills;Source;Specific qualifier value;supercomputer;System;Systems Biology;Technology;Tissues;tool;United States National Institutes of Health;Update;usability;Visual;Visualization

PROJECT_TITLE: Metabolomics Workbench - National Metabolomics Data Repository

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]