NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative The proposed research is relevant to public health as it will advance new sex-based precision medicine treatments by answering critical questions regarding the contribution of biological sex to mechanisms underlying heterogeneity in schizophrenia. This project is relevant to NIMH’s mission to determine modifiers of maturational and illness trajectories during sensitive developmental periods (strategic objective 2.1), as it will determine sex and pubertal modifiers of neurodevelopmental trajectories that contribute to the emergence of schizophrenia.

PI_NAMEs: GUYER, AMANDA E (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 10 year old;16 year old;Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Affect;Age;age related changes;Anhedonia;Anxiety;Back;biological sex;Brain;Child;Child Behavior;Clinical;cognitive development;Corpus striatum structure;Data;Delusions;Development;Diagnostic;Dimensions;disability;effective therapy;emerging adult;emotion regulation;Emotional;Exhibits;Female;financial incentive;follow-up;Functional Magnetic Resonance Imaging;Gonadal Steroid Hormones;Grant;Hallucinations;Heterogeneity;Hormones;ineffective therapies;innovation;Interview;lens;Libido;Literature;Longitudinal Studies;male;Measures;Mediating;Mental Depression;Mission;Moods;National Institute of Mental Health;negative mood;Negative Valence;network dysfunction;neural network;neurobehavioral;neurodevelopment;Outcome;Patients;Population;Positive Valence;precision medicine;Psychopathology;Psychoses;psychotic;Puberty;Public Health;Questionnaires;Research;Research Domain Criteria;response;Rest;reward processing;Schizophrenia;schizophrenia spectrum disorder;sex;Sex Differences;sexual dimorphism;Shapes;Site;societal costs;Source;Symptoms;System;Testing;Time;timeline;Treatment Protocols;treatment response;Work

PROJECT_TITLE: Sex and pubertal influences on developmental trajectories of brain networks involved in schizophrenia

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Data Science;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NUTRITION

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) are influenced by genetic variation and environmental exposures, yet little work has been done to understand how upstream social, built, and physical environmental exposures interact with polygenic risk to influence biological mechanisms that cause ADRD. In the proposed research, (F99) I will identify key environmental exposures associated with ADRD, independent of and interacting with polygenic risk. (K00) I will then investigate the changes in transcriptomic and proteomic profiles that mediate the associations between the environment and ADRD.

PI_NAMEs: XUE, DIANE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;adjudication;Aging;Air;Air Pollution;Algorithms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;ambient air pollution;Ancillary Study;Award;Biological;Biological Markers;Biological Process;Biology;brain health;career;career development;Cause of Death;Cognitive;cohort;Computing Methodologies;Data;Data Analyses;data integration;Dementia;dementia risk;design;Developed Countries;Diagnosis;differential expression;Disease;diverse data;Dose;Education;Environment;Environmental Exposure;Environmental Risk Factor;ethnic diversity;Ethnic Population;Exposure to;Fellowship;fine particles;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Risk;Genetic study;Genetic Variation;genome wide association study;genomic locus;genomic profiles;Genomics;Goals;hazard;Health;Heritability;human old age (65+);Impaired cognition;improved;Individual;interest;Intervention;Late Onset Alzheimer Disease;Location;longitudinal analysis;Longitudinal cohort;Machine Learning;Mediating;Mediator;Methods;Modeling;modifiable risk;Molecular;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;multiple omics;Neighborhoods;Nerve Degeneration;Neurodegenerative Disorders;Nitrogen Dioxide;non-genetic;Outcome;Parents;Participant;Pathogenesis;Pathway interactions;Pattern;Persons;Pharmacologic Substance;Phase;Policies;polygenic risk score;Population;Postdoctoral Fellow;Precision therapeutics;Predictive Value;Prevention;Prevention strategy;Proteins;proteomic signature;Proteomics;racial diversity;Reporting;Research;research and development;Research Personnel;resilience;response;Risk;Risk Factors;risk prediction;Safety;Scoring Method;social;social cohesion;social health determinants;Socioeconomic Status;Subgroup;Testing;Training;training data;transcriptomics;treatment strategy;Work

PROJECT_TITLE: Integrating Polygenic Risk and Environmental Exposures to Uncover Biological Mechanisms Underlying Dementia in a Diverse Cohort


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases

ORG_CITY: HANOVER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: The blood vessels deliver oxygen and nutrients and remove waste to and from every organ of the body. Endothelial cells line all the blood vessels forming a barrier between blood and tissues. In specific organs, endothelial cells form specialized subcellular structures called endothelial fenestrae and endothelial diaphragms. Recent data show that endothelial diaphragms are critical for life and their components and malfunction are implicated in a large host of human diseases (protein losing enteropathy, cancer, preeclampsia, kidney failure, diabetes and inflammation). There is little known on how endothelial fenestrae and diaphragms assemble their molecular components, which are addressed in this proposal.

PI_NAMEs: STAN, RADU VIRGIL (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adult;Animal Model;Antibodies;Antigens;B-Lymphocytes;Basement membrane;Biogenesis;Biological Assay;Biology;Blood;Blood capillaries;Blood Vessels;cancer immunotherapy;cancer therapy;Capillarity;Caveolae;Cell Culture System;Cell Culture Techniques;Cell Line;Cell membrane;Cell model;Cellular Structures;Clinic;Clinical;Collaborations;Data;Defect;Diabetes Mellitus;Diarrhea;Discontinuous Capillary;Disease;Endocrine Glands;Endothelial Cells;Endothelium;Exocrine Glands;Extracellular Matrix;Extracellular Matrix Proteins;Fenestrated Capillary;FGF5 gene;FGFR1 gene;gain of function;Gene Expression;Gene Modified;Genetic;Genetic Engineering;Genetically Engineered Mouse;Growth Factor;Homeostasis;Human;human disease;Immune response;Immune System Diseases;In Situ;Inflammation;innovation;insight;Integrin Binding;Integrins;interest;Investigation;KDR gene;Kidney Diseases;Kidney Failure;Kidney Glomerulus;Knowledge;Laboratories;Laminin;Lead;Leukocytes;Life;Literature;Liver;Liver diseases;loss of function;loss of function mutation;lymph nodes;Maintenance;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;MAPK8 gene;Medical;Microvascular Permeability;Modeling;Molecular;Morphogenesis;Mus;Myocardial Infarction;novel;novel therapeutic intervention;Nutrient;Organ;Organelles;Outcome;Oxygen;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Perinatal mortality demographics;Permeability;Phenotype;Physiological;PIK3CG gene;Play;Positioning Attribute;Pre-Eclampsia;Process;Property;Protein-Losing Enteropathies;Proteins;Proto-Oncogene Protein c-kit;Reagent;receptor;Receptor Signaling;reconstitution;Regulation;Regulatory Pathway;Research;Respiratory Diaphragm;Retina;Retinal Diseases;Role;Signal Pathway;Signal Transduction;Structure of choroid plexus;Subcellular structure;Syndrome;synergism;Testing;Therapeutic;Tissues;tool;Toxic Hepatitis;tumor growth;Validation;vascular bed;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular Permeabilities;Vesicle;Viral;Visceral;wasting;Work

PROJECT_TITLE: Novel regulators, components and function of endothelial diaphragms

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Opioids;Prevention

ORG_DEPT: PSYCHIATRY

ORG_STATE: CA

PHR: Project Narrative Social relationships are crucially important to human health; however, we do not fully understand what in our brains drives us to form relationships, to feel loss when the relationships end, or to allow our partners to reduce our stress levels (also called “social buffering”). In this project, we will study titi monkeys, which form adult pair bonds, using imaging and drug manipulations to examine the neurobiology of social buffering and separation.

PI_NAMEs: BALES, KAREN L. (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acute;acute stress;Address;Adult;Behavioral;Biological;biological adaptation to stress;Brain;Buffers;Callicebus cupreus;Cardiovascular Diseases;Chronic;diet and exercise;Distress;Down-Regulation;dysphoria;Etiology;Exhibits;Female;Health;Health behavior;Hormonal;Hormones;Human;Hypothalamic structure;Image;improved;Individual;kappa opioid receptors;kappa receptors;Laboratories;Lead;Macaca mulatta;male;Mental disorders;Modeling;mortality;Mus;neurobiological mechanism;Neurobiology;nonhuman primate;Nucleus Accumbens;Opioid;Oxytocin;Pair Bond;Partner in relationship;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Positron-Emission Tomography;preference;Primates;Rattus;receptor binding;response;Risk;Role;social;social attachment;Social Distance;social relationships;social separation;social stress;Stress;stress management;stressor;Stroke;survivorship;System;Testing

PROJECT_TITLE: Kappa opioid and oxytocin interactions in social buffering and separation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative. These studies will reveal important new insights into the virus epitopes that elicit type specific and broadly neutralizing antibody (bnAB), reveal mechanisms of cross protection, antibody neutralization and escape, and provide an atomic level understanding of HuNoV neutralization and pandemic strain emergence mechanisms, leading to improved 2nd generation vaccines for in vivo testing.

PI_NAMEs: BARIC, RALPH S (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Antibodies;Antibody Repertoire;Antibody-mediated protection;Antigens;B cell repertoire;B-Lymphocyte Subsets;B-Lymphocytes;Back;Binding;Biological Assay;Blocking Antibodies;Blood Group Antigens;Capsid Proteins;Catalogs;Cell Culture Techniques;Cessation of life;cohort;Collection;Complex;cross immunity;cross reactivity;Cryoelectron Microscopy;Crystallography;design;Development;Early identification;Elderly;Epidemic;Epitopes;Evolution;Gastroenteritis;Generations;Germ Lines;Goals;Human;human monoclonal antibodies;Humoral Immunities;Immune;Immune response;Immunity;immunogenic;Immunoglobulin Somatic Hypermutation;immunosuppressed;improved;in vivo;in vivo evaluation;Infant;Infection;insight;Maps;Medical;Molecular;Molecular Analysis;Monoclonal Antibodies;mutant;Nature;neutralizing antibody;new technology;Norovirus;novel;pandemic disease;particle;Peripheral;Phenotype;prevent;programs;Property;Recombinant Antibody;Recombinants;response;Sampling;Serology;Serum;Site;Specificity;Structure;System;Testing;Time;time use;Translating;Trefoil Motif;Vaccination;vaccination strategy;Vaccine Design;Vaccinee;Vaccines;Virion;Virus;Virus Diseases;Virus Receptors;Work

PROJECT_TITLE: Antibody Landscape following Human Norovirus Infection and Vaccination

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Data are limited regarding risk factors for progression of gastric intestinal metaplasia to gastric cancer in the Unites States (US) population, and regarding which individuals may benefit from preventative interventions such as endoscopic screening/surveillance. The proposed research will utilize pathology data from across the US to characterize the prevalence of extensive and limited gastric intestinal metaplasia, and the respective risks of progression of these lesions to gastric cancer. Subsequently, we will utilize simulation modeling to assess how targeted screening and surveillance can impact health outcomes in patients across 64 specific, diverse risk-factor profiles, both on a patient level and a population level.

PI_NAMEs: LASZKOWSKA, MONIKA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Accounting;Adult;Advisory Committees;Affect;Age;American;Asian;Award;Bass;biomarker signature;Cancer Model;cancer subtypes;care costs;care outcomes;career;career development;Clinical Research;cohort;Collection;Colorectal Cancer;Computer Simulation;cost;cost effective;cost-effectiveness ratio;Country;Coupled;curative treatments;Data;Databases;Development Plans;Diffuse gastric cancer;Dysplasia;Early Intervention;Eligibility Determination;Epithelium;ethnic difference;ethnic minority;Ethnic Origin;Europe;Family;Female;Funding;Gastric Adenocarcinoma;gastric intestinal metaplasia;Gastroenterology;gastrointestinal;Gastrointestinal tract structure;Gender;Guidelines;Health;health assessment;Healthcare Systems;Helicobacter Infections;Helicobacter pylori;High Prevalence;high risk;high risk population;Hispanic;Hospitals;Immigrant;improved;improved outcome;Incidence;incremental cost-effectiveness;Individual;Infection;Inherited;Institution;Intervention;intervention program;Investigation;Japan;Knowledge;Lesion;Low Prevalence;male;Malignant Neoplasms;malignant stomach neoplasm;Mass Screening;Mentorship;Modeling;models and simulation;mortality;Natural History;Not Hispanic or Latino;Operative Surgical Procedures;Outcome;Outcome Assessment;Pathology;Patients;Phenotype;Policies;Population;Precancerous Conditions;premalignant;Prevalence;prevent;preventive intervention;profiles in patients;progression risk;prophylactic;prospective;Public Health;Publishing;Race;racial difference;racial minority;Randomized, Controlled Trials;Recording of previous events;Regimen;Reporting;Research;Research Personnel;response;Risk;Risk Factors;risk stratification;screening;Screening for Gastric Cancer;screening program;SEER Program;Smoking History;Societies;Specimen;Stomach;Subgroup;surveillance data;System;Testing;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans Health Administration;Work

PROJECT_TITLE: A Targeted Approach to the Surveillance of Precursor Lesions for Gastric Cancer

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Comprehensive cardiovascular monitoring is needed to care for very sick patients. However, such monitoring currently requires multiple devices that are invasive, manual, or specialized. In this project, the standard automatic arm cuff device will be extended through innovative algorithms to measure blood pressure with superior accuracy, blood flow, and cardiac function, and the new device will then be evaluated for accuracy in patients.

PI_NAMEs: MAHAJAN, AMAN  (contact);MUKKAMALA, RAMAKRISHNA

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Achievement;algorithm training;Algorithms;arm;Automated Clinical Decision Support;Blood flow;Blood Pressure;Blood Pressure Monitors;Cardiac Output;Cardiovascular system;Caring;Catheters;Clinical;clinical care;cohort;Collection;commercialization;Complex;Computer software;Custom;Data;Detection;Devices;Diagnosis;Diastolic blood pressure;Echocardiography;EFRAC;Enhancement Technology;Goals;Health Care Costs;heart function;hemodynamics;Hospital Costs;Hospitals;Hypotension;improved;innovation;intelligent algorithm;Intensive Care;Intervention;Left Ventricular Ejection Fraction;Liquid substance;Machine Learning;machine learning algorithm;Manuals;Measurement;Measures;Medical center;Monitor;monitoring device;novel;Operative Surgical Procedures;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Physiological;Population;Precision therapeutics;pressure;Pulmonary artery structure;Pulse Pressure;real time monitoring;Real-Time Systems;Research Project Grants;Surgical Management;Systems Integration;Technology;Testing;Time;Titrations;training data;Translating;Universities;Variant

PROJECT_TITLE: Smart Cuff: Multi-Parameter Hemodynamic Monitoring via a Single Convenient Device

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: In order to better understand how HIV affects the brain, we will study the cell susceptible to HIV infection--human microglia-- in the mouse brain. This includes novel experimental approaches that monitor change in microglial chromosomal organization in longitudinal context, something that has not been achieved until now.

PI_NAMEs: AKBARIAN, SCHAHRAM  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Animals;antiretroviral therapy;Autopsy;Base Pairing;Blood;Brain;brain cell;Cell Culture Techniques;cell type;Cells;Cessation of life;Chromatin;Chromatin Fiber;Chromosome Structures;design;Deterioration;Epidemic;epigenome;epigenomic profiling;epigenomics;Exposure to;Face;Genetic Engineering;Genome;Genomic approach;Hematopoietic stem cells;High Prevalence;HIV;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;Human;human induced pluripotent stem cells;Laboratories;Length;Life;Maps;Microglia;Molecular Profiling;Monitor;Mus;Myelogenous;Narcotics;neuroAIDS;neurogenomics;novel;Pattern;Persons;Predisposition;Resolution;Rewards;Site;Stimulant;Substance Use Disorder;Time;Transcript;transcriptome;Viral;virtual;Work;Xenograft Model

PROJECT_TITLE: Single Chromatin Fiber Sequencing and Longitudinal Epigenomic Profiling in HIV+ Brain Cells Exposed to Narcotic and Stimulant


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Arthritis;Dental, Oral, and Craniofacial Disease;Osteoarthritis;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narrative There is an urgent need for the development of non-invasive therapies for the degenerative process of the temporomandibular joint. The proposed project addresses a novel hypothesis that intermittent administration of parathyroid hormone (I-PTH) exerts a chondroprotective role, and the anabolic effects caused by its administration would partially reverse degeneration of the TMJ of mice. Furthermore, we propose that these effects are mainly regulated by FGFR3 signaling. !

PI_NAMEs: DUTRA, ELIANE  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Affect;Affinity;Anabolism;Animals;Basic Science;Binding;biomechanical test;career development;Cartilage;Cartilage injury;cartilage regeneration;cartilage repair;Cells;Chondrocytes;chondroprotection;Clinical;clinical application;clinical development;Clinical Management;clinically relevant;Collagen;condylar cartilage;craniofacial;Data;Degenerative polyarthritis;Dental Schools;Development;disability;Disabling;Disease;Euthanasia;experience;experimental study;Extracellular Matrix;FDA approved;FGF2 gene;FGFR3 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptor 2;Foundations;Future;Gender;Goals;Health;Health Occupations;Hypertrophy;Impaired healing;In Vitro;in vivo;Individual;inhibitor;injured;insight;Intervention;Leadership;Ligands;Logic;loss of function;Mandible;Mandibular Condyle;Medicine;Mentored Research Scientist Development Award;Mentors;microCT;mineralization;Modeling;Molecular;mRNA Expression;multidisciplinary;Mus;Musculoskeletal;Musculoskeletal Diseases;National Institute of Dental and Craniofacial Research;Natural regeneration;Nature;next generation;novel;novel therapeutic intervention;osteochondral tissue;Pain;palliative;Patients;Pharmacy (field);Play;prevent;Process;Proliferating;Proliferation Marker;Proteins;PTH gene;Publishing;Receptor Protein-Tyrosine Kinases;repaired;Reporter Genes;Reporting;Research;response;RNA Interference;Role;Saline;Science;Scientist;Sclerosis;Signal Transduction;Skeletal Development;Stimulus;subchondral bone;Temporomandibular Joint;Temporomandibular Joint Disorders;Temporomandibular joint osteoarthritis;Testing;Therapeutic Intervention;Time;Tissues;Training Programs;transcriptome sequencing;Transgenic Organisms;Translating;Translational Research;translational research program;United States;United States National Institutes of Health

PROJECT_TITLE: The role of FGFR3 in the effects of PTH in the Mandibular Condyle

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: GENETICS

PHR: These experiments will provide tremendous insight into the mechanisms of RNA processing in humans, and how RNA binding proteins regulate their own levels and the levels of other RNA binding proteins. As the vast majority of human genes are alternatively spliced, it is likely the discoveries we make will be of direct relevance to human health. This work will also provide insight into the mechanisms of adaptation in the immune systems of prokaryotes. In addition to enhancing our understanding of the basic science of prokaryotic immune systems, there is tremendous potential that this work could lead to the development of new tools that can be used for genome editing applications.

PI_NAMEs: GRAVELEY, BRENTON R. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adaptive Immune System;Address;Alternative Splicing;Basic Science;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Development;DNA;DNA Sequence;Elements;experimental study;Future;Gene Expression;Gene Proteins;Genes;Genetic Transcription;Genome;genome editing;Genomics;Guide RNA;Health;Human;Immune system;Immunologic Memory;innovation;insight;Invaded;memory encoding;Messenger RNA;mRNA Precursor;nanopore;nuclease;Nucleic Acids;Organism;Plasmids;Process;Prokaryotic Cells;Proteins;Proteome;Reporter;RNA interference screen;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;single-cell RNA sequencing;System;tool;Virus;Work

PROJECT_TITLE: Genomic Analysis of Nucleic Acid Transactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Stem cell therapy is a promising strategy to tissue regeneration. However, suboptimal stem cell homing to the injured tissue hampers the efficiency and outcome of cell therapy. In the proposed study we employ biomimetic and drug delivery principles to achieve targeted delivery and sustained release of stem cell factors in the injured tissue.

PI_NAMEs: CHENG, KE  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: adult stem cell;Animals;Applications Grants;Area;Binding;Biological;Biological Assay;Biomimetics;Blood Platelets;Blood Vessels;cancer therapy;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular system;Cell Line;Cell secretion;Cell Therapy;Cells;Chest;Clinic;clinically relevant;Cryopreservation;cytotoxicity;design;Diffusion;Dinoprostone;donor stem cell;dosage;Drug Delivery Systems;Encapsulated;Fibrosis;Foundations;Glycolates;Grant;Growth Factor;Heart;Heart Injuries;Homing;Human;in vitro testing;Infarction;Inflammation;Injections;injured;Injury;innovation;interest;Intravenous;Ischemia;Lung;Medicine;Membrane;mesenchymal stromal cell;Modeling;Muscle Cells;Myocardial Infarction;myocardial injury;Myocardial Reperfusion Injury;Myocardium;nano;nanomedicine;nanoparticle;nanosized;Nature;novel;Organ;Outcome;paracrine;particle;porcine model;Procedures;Proliferating;Property;Rattus;Receptor Signaling;recruit;regenerative;regenerative therapy;repaired;Reperfusion Injury;Rodent;Rodent Model;Safety;Scheme;Standardization;stem cell delivery;Stem Cell Factor;stem cell therapy;stem cells;Stromal Cells;targeted delivery;Technology;technology platform;Testing;Therapeutic;therapeutic nanoparticles;tissue regeneration;Tissues;Translating

PROJECT_TITLE: Drug Delivery and Biomimetic Approaches for Optimal Stem Cell Therapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Penn Human Pancreas Analysis Program – T2D Narrative The past decades have seen a dramatic improvement in our ability to phenotype and molecularly profile human tissues relevant to the etiology of type 2 diabetes with unprecedented resolution, at the genomic, epigenomic, protein, and functional levels. Here we will employ state-of-the-art technologies to determine all aspects of pancreas biology as it pertains to type 2 diabetes, profile human pancreatic islets with multiple assay modalities, and make the vast data accumulated available through the highly accessible PANC-DB. This comprehensive profiling of the natural history of Type 2 diabetes will pave the way for future discoveries of new treatment modalities for diabetes.

PI_NAMEs: KAESTNER, KLAUS H (contact);NAJI, ALI

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipose tissue;Adolescent;Architecture;ATAC-seq;biobank;Bioenergetics;Biological Assay;Biology;Biopsy;Blood;Calcium;Cell Physiology;Cell surface;Cells;Collaborations;Colon;Communities;Cyclic GMP;Cytometry;Data;data access;Data Analyses;data integration;data resource;data sharing;data submission;data visualization;Databases;Diabetes Mellitus;Diagnosis;Disease;DNA;Duodenum;Epidemic;epigenomics;Epithelial Cells;Etiology;experience;Funding;Future;Genetic;Genomic DNA;Genomics;Glucagon;Glucose;Heterogeneity;Histologic;Hour;Human;human leukocyte antigen testing;human tissue;Image;improved;Inflammatory Response;Infrastructure;Insulin;Insulin-Dependent Diabetes Mellitus;Intestines;Investigation;islet;Islet Cell;Islets of Langerhans;Knowledge;Leadership;Liver;Lymphocyte;maturity onset diabetes of the young;Measurement;Medical History;Medical Records;member;Metabolic;Metadata;methylome;migration;Modality;molecular phenotype;Molecular Profiling;morphometry;multidimensional data;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;next generation sequencing;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organ;Organ Donor;Organ Procurements;Oxygen Consumption;Pancreas;Patients;Pennsylvania;Phenotype;Physiological;Population;Process;programs;Protein Analysis;protein biomarkers;Proteins;PTPRC gene;Publications;quantitative imaging;Recording of previous events;Research Personnel;Resolution;response;sample fixation;single cell ATAC-seq;single-cell RNA sequencing;Skeletal Muscle;Somatostatin;Sorting;Stains;Technology;tissue archive;Tissues;transcriptome;transcriptome sequencing;United States National Institutes of Health;Universities;Visualization;whole slide imaging;Work

PROJECT_TITLE: The Human Pancreas Analysis Program for Type 2 Diabetes


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Diabetes;Lymphatic Research;Regenerative Medicine;Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative A thorough understanding of cells and molecules that regulate skin wound healing is essential for the generation of tissue-specific regenerative therapies to effectively treat human disease. Since the manner in which lymphatic vessels function during skin wound healing is largely unknown, we will define how these major but poorly understood cells function during skin wound healing. Our work will improve our understanding of the cells and molecules that control basic skin regeneration, how lymphatic endothelium function in this process, and will have global relevance for other regenerative tissues in patients with lymphatic disorders.

PI_NAMEs: HORSLEY, VALERIE  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;aged;Aging;American;angiogenesis;Angiogenesis Inhibition;Apoptosis;Area;Biology;Blood;Blood Vessels;Cell Culture Techniques;Cell Physiology;Cell surface;Cells;Chronic;chronic wound;Cicatrix;Collaborations;Data;Defect;defined contribution;Dermal;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Endocytosis Inhibition;Endothelial Cells;endothelial regeneration;Endothelium;Epithelial Cells;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Generations;Genetic;Genomics;Goals;healing;Heterogeneity;Homeostasis;Human;human disease;Hypervascular;improved;In Vitro;in vitro Assay;in vivo;Injury;KDR gene;Laboratories;Lymphangiogenesis;Lymphatic;Lymphatic Diseases;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;lymphatic malformations;lymphatic vessel;Lymphedema;Malignant Neoplasms;mathematical model;Measures;Modeling;Molecular;mouse model;mRNA Expression;Mus;Natural regeneration;new therapeutic target;non-healing wounds;novel;old mice;older patient;Operative Surgical Procedures;overpopulation;Pathologic;Patients;Phase;Population;Process;Production;Proliferating;regenerative;regenerative therapy;regenerative tissue;Regulation;repaired;Risk;Role;Signal Pathway;single-cell RNA sequencing;Skin;Skin Aging;skin disorder;skin fibrosis;skin regeneration;Skin repair;skin wound;Skin wound healing;Swelling;System;Testing;therapeutic target;Tissue Expansion;Tissues;Vascular Endothelial Growth Factor Receptor-3;VEGFC gene;Work;wound;wound healing

PROJECT_TITLE: Defining the role of lymphatic vessels in wound healing

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Breast cancer is one of the most common cancers in the world, with over 70% of breast cancers harboring the activation of the estrogen receptor α (ERα), a key oncogenic transcription factor. We have, made a striking discovery that ERα has an RNA-binding protein that acts to change gene expression at the post-transcriptional level, which is critical for tumor development. The findings of this proposal will be instrumental in revealing a new “Achilles’ Heel” of ERα oncogenic activity in breast cancer.

PI_NAMEs: RUGGERO, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3' Untranslated Regions;Affect;antagonist;Apoptotic;Binding;biological adaptation to stress;biomarker discovery;Breast Cancer Cell;Breast Cancer cell line;breast cancer progression;Breast Cancer therapy;Bypass;cancer cell;Cancer Cell Growth;cancer therapy;Cell Cycle Arrest;Cell Death;Cells;Cellular Stress;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Critical Pathways;crosslink;crosslinking and immunoprecipitation sequencing;Data;Development;Disease;DNA Binding;Drug resistance;ESR1 gene;Etiology;experimental study;functional genomics;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Transcription;genome-wide analysis;Grant;Hand;High-Throughput Nucleotide Sequencing;Immunoprecipitation;In Vitro;in vivo;inhibitor;insight;Knock-in Mouse;Knowledge;Lesion;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;MCL1 gene;Mediating;Messenger RNA;Modeling;Molecular;mouse model;mRNA Stability;mRNA Translation;Mutate;Mutation;Neoplasm Metastasis;novel;novel therapeutics;Oncogenic;Pathway interactions;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;programs;Proliferating;Proteins;Research;Resistance;response;ribosome profiling;RNA;RNA Binding;RNA metabolism;RNA Recognition Motif;RNA-Binding Proteins;Role;Series;Stimulus;Stress;Tamoxifen;Technology;Testing;Therapeutic;therapeutic evaluation;Transcript;transcription factor;translation factor;Translations;treatment response;tumor;tumor initiation;tumor progression;Xenograft Model;Xenograft procedure

PROJECT_TITLE: ERa is a novel RNA-binding protein controlling breast cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Body manganese homeostasis needs to be tightly controlled to meet the dual challenge of avoiding deficiency and preventing overload. Metal transporters responsible for delivering manganese into or out of cells play significant roles in this control. This project seeks to understand the function of a metal transporter ZIP14 in regulating manganese homeostasis.

PI_NAMEs: ZHAO, NINGNING  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Age;Animals;Apical;Asthma;Behavioral;Biliary;Bioinformatics;Biology;Biometry;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Brain;brain parenchyma;Caco-2 Cells;Cells;Cellular Assay;Cerebrospinal Fluid;Childhood;Clinical;Cognitive deficits;Compensation;Data;Defect;Deposition;Development;Dietary Intervention;Dietary Manganese;Disease;Dyslipidemias;Enterocytes;Enzymes;Excretory function;Gene Modified;Goals;Growth;Health;Hepatic;Hepatobiliary;Homeostasis;Human;Impairment;Individual;Intervention;Intestines;knock-down;Knock-out;Knockout Mice;Knowledge;Lead;Life;Liver;Location;loss of function mutation;Manganese;manganese deficiency;Manganism;Mediating;member;Metabolism;Metals;Modeling;Molecular;Molecular and Cellular Biology;mouse model;Mus;Mutation;Nervous System Disorder;Neurobiology;Neurologic;Neurologic Symptoms;Neurons;new therapeutic target;Nutrient;Organ;Osteoporosis;Patient observation;Patients;Physiological;Play;prevent;Prevention strategy;Proteins;Proteomics;Regulation;Research;RNA Interference;Role;Scientist;Site;Small Intestines;Structure of choroid plexus;Testing;Therapeutic;therapeutic target;Tissues;Toxic effect;treatment strategy;Work

PROJECT_TITLE: Molecular mechanism underlying the regulation of manganese homeostasis

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative In 2018 suicide was reported as the 2nd leading cause of death among Black Americans ages 10-14-years-old; suicide prevention resources designed specifically for Black youth, however, remain scant. Where therefore propose the development of a multilevel cultural adaptation of the Signs of Suicide (SOS) prevention program and will conduct a pilot randomized controlled trial with students, parents, and school personnel in Chicago Public Schools to assess feasibility and examine underlying mechanisms that contribute to suicidality among Black youth. Findings derived from this project will contribute to public health priorities by offering unique insight into the factors that either prevent or promote suicide among Black youth and could be replicated in other schools serving Black students and their families across the nation.

PI_NAMEs: GOODWILL, JANELLE RENEE (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: 14 year old;access disparities;Administrator;Adolescent;African American student;Age;Asphyxia;Attitude;Belief;Binding;Black American;Black race;Cause of Death;Chicago;Child;Child Mental Health;children of color;Clinical Trials;cohort;Color;Communities;community setting;Complex;Data;design;Detection;Development;Disparity;Economics;Educational Curriculum;Effectiveness;eighth grade;Equity;Evaluation;evidence base;Evidence based program;Familiarity;Family;Feedback;Feeling suicidal;follow-up;Foundations;Frequencies;Future;Goals;Health Resources;Health Services Accessibility;help-seeking behavior;high school;High School Student;Hospitals;Human Resources;ideation;Individual;Inequity;insight;internalized stigma;Intervention;Interview;junior high school;Knowledge;Link;media use;Mediating;member;Mental Depression;Mental Health;Mental Health Services;Middle School Student;parenting intervention;Parents;peer;Perception;Persons;pilot test;Positioning Attribute;prevent;Prevention program;preventive intervention;Procedures;programs;public health priorities;Race;Randomized;Randomized, Controlled Trials;reducing suicide;Reporting;Research Personnel;Resources;response;Risk Factors;Sampling;School-Age Population;Schools;service utilization;Shapes;social media;social stigma;Stigmatization;Students;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;teacher;Testing;therapy design;Training;treatment services;underserved community;university student;Work;Youth

PROJECT_TITLE: Piloting a culturally adapted multilevel suicide prevention intervention in schools for Black youth and their families


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE microRNAs are important in many biological processes because they downregulate gene expression to control cell fate decisions, and mis-regulation by microRNAs contributes to multiple pathological states. Understanding how a miRNA controls cell fate decisions requires both identifying the genes it downregulates and demonstrating how that regulation contributes to a cellular pathway. This is the goal of the proposed project, which develops an experimental strategy to unravel the biological roles of speciﬁc miRNAs, using miR-1 and miR-206 in skeletal muscle cell differentiation as a model system.

PI_NAMEs: KUGEL, JENNIFER F. (contact)

PROJECT_TERMS: Binding;Biological;Biological Assay;Biological Models;Biological Process;biological systems;Cell Differentiation process;Cell Fate Control;Cell Line;Cell Physiology;Cell Proliferation;Cells;Complex;Data;Disease;Down-Regulation;Embryonic Development;experimental study;Gene Expression;Genes;Goals;in vivo;in vivo Model;Individual;Injury;Knock-out;Knowledge;Mediating;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;mouse model;mRNA Expression;Mus;Muscle Fibers;muscle regeneration;Myoblasts;myogenesis;Pathologic;Pathway interactions;Phenotype;Play;premature;prevent;Process;Proliferating;Regulation;Regulator Genes;Research;RNA;Role;skeletal muscle differentiation;success;Techniques;Testing;Undifferentiated;Validation;Work

PROJECT_TITLE: Unraveling the biological roles of specific miRNAs, from experimental target identification through functional characterization

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Identifying older adults at-risk for falls is critical for implementing preventative interventions aimed at reducing adverse outcomes, but developing prediction models for fall-risk remains challenging due to analytic shortcomings, missing data, and limitations of electronic health record (EHR) data. This K25 Mentored Quantitative Research Development Award provides Dr. Jaime Lynn Speiser with essential training in aging, missing data methodology, EHR data analysis, and career development to facilitate her transition into an independent biostatistical researcher in aging. The prediction model developed in this K25 research proposal and validated with EHR data will aid in identification of at-risk individuals for falls through an automated mechanism.

PI_NAMEs: SPEISER, JAIME LYNN (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;adverse outcome;Aging;aging process;Award;Big Data;Biometry;Body Composition;career;career development;Caregivers;Caring;Clinical;Communication;Dangerousness;Data;Data Analyses;data imputation;Data Set;Dedications;Dependence;Development;Early identification;Educational workshop;Elderly;Electronic Health Record;Environment;experience;fall risk;falls;follow-up;forest;functional decline;functional status;Future;Geriatrics;Gerontology;Goals;Grant;Health;health data;Healthcare;Healthcare Systems;high risk;human old age (65+);improved;Individual;Informatics;innovation;Journals;Knowledge;Knowledge acquisition;Leadership;Learning;Longitudinal cohort study;Machine Learning;machine learning method;machine learning model;Measurement;Measures;medical schools;Medicine;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;novel;older adult;Outcome;Outcome Measure;Participant;Patient-Focused Outcomes;Patients;Performance;Persons;predictive modeling;Predictive Value;Preventive care;preventive intervention;Provider;Research;research and development;Research Personnel;Research Proposals;research study;Risk;Risk Factors;Sampling;severe injury;skills;Statistical Methods;stem;symposium;Techniques;Testing;Time;Training;Trees;Validation;Visit;Work;Writing

PROJECT_TITLE: Development and Validation of a Prediction Model for Longitudinal Fall Risk in Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Antimicrobial Resistance;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The extent to which African HIV universal treatment programs can reach all HIV-positive persons and suppress them over their entire lives as well as reverse rising trends in HIV drug resistance remains unknown. Moreover, the introduction of the COVID-19 pandemic has disrupted HIV treatment and prevention services. This study aims to measure the impact of COVID-19 on key HIV programmatic outcomes, including HIV viremia, drug resistance, and new cases of HIV in a Ugandan population with a high HIV burden.

PI_NAMEs: GRABOWSKI, MARY KATHRYN (contact)

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adoption;Africa;African;aged;AIDS prevention;antiretroviral therapy;care seeking;Caring;cohort;Cohort Studies;Communities;Continuity of Patient Care;Country;COVID-19;COVID-19 detection;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Development;Diagnosis;Drug resistance;Emergency Situation;epidemic response;Epidemiology;Failure;Focus Groups;Future;Goals;Health Personnel;Health Services Accessibility;Health Status;Health system;HIV;HIV drug resistance;HIV Seropositivity;Household;Incidence;Individual;Infection;Integrase Inhibitors;Interruption;Interview;Life Cycle Stages;Measures;Methods;Nature;Newly Diagnosed;NNRTI-resistance;Outcome;Participant;Patients;Pattern;Persons;Pharmacists;Phylogenetic Analysis;Population;Population Attributable Risks;population based;Population Study;Prevalence;Prevention program;prevention service;Privatization;programs;prospective;Qualitative Methods;Reporting;Resistance;response;Risk;service providers;Services;Social Distance;Social Mobility;Source;spatiotemporal;stay-at-home order;Surveys;Testing;Time;transmission process;treatment program;treatment services;trend;Uganda;Uncertainty;United States;uptake;Viral;Viral Load result;Viremia;Visit

PROJECT_TITLE: Long-term impact of universal treatment and dolutegravir on population HIV virologic and incidence outcomes in Africa: The LONGVIEW Study

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Liver Disease;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: Biliary atresia is the leading cause of pediatric liver transplantation in the United States, however little is known about the pathogenesis and factors which influence outcomes. The gut microbiome has multiple effects on other disease processes involving the liver. This proposal is the first to longitudinally characterize the microbiome in a multicenter study to identify how the microbiome contributes to outcomes.

PI_NAMEs: TESSIER, MARY ELIZABETH MCCONNELL (contact)

PROJECT_TERMS: Advisory Committees;Affect;Ally;Ancillary Study;Anti-Inflammatory Agents;bacterial community;Bifidobacterium;Bile Acids;Bile fluid;Biliary Atresia;biliary tract;biobank;Bioinformatics;Biometry;Bioreactors;Board Certification;career development;Cell Culture Techniques;Child;Childhood;Cholestasis;Chronic;Clinical;Clinical Trials Design;cohort;collaborative environment;college;Communities;Complex;cytokine;Data;design;Disease;disease model;Educational Status;Endotoxemia;Enterocytes;Environment;Etiology;Extrahepatic;fecal microbiome;Feces;Funding;Future;Gastroenterologist;Gastroenterology;Genes;genome sequencing;Goals;Grant;gut microbiome;Homeostasis;Human;Human Milk;improved;Incidence;Infant;Infant Development;Inflammatory;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intestines;Investigation;Learning;Life;Liver;Liver Fibrosis;liver transplantation;longitudinal database;Longitudinal Studies;Medical center;Medicine;Mentors;Mentorship;Metadata;Metagenomics;Microbe;microbial;microbial community;microbial signature;microbiome;microbiome alteration;microbiome research;microbiome sequencing;milk intake;Morbidity - disease rate;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Operative Surgical Procedures;Outcome;Participant;pathogen;Pathogenesis;Pathway interactions;patient oriented research;Pediatric Hospitals;Physicians;pressure;Process;Production;Productivity;professor;Property;prospective;Prospective Studies;Publishing;recruit;repository;Research;Research Personnel;restoration;Role;Sampling;Scientist;Signal Transduction;Site;stool sample;Techniques;Technology;tenure track;Testing;Texas;Therapeutic;Time;Training;United States;United States National Institutes of Health;whole genome;Whole-Genome Shotgun Sequencing;Work

PROJECT_TITLE: A multi-center study of the microbiome in biliary atresia


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

PHR: PROJECT NARRATIVE Histone post-translational modifications (PTMs) are some of the most widely studied epigenomic factors, and alterations in histone PTM abundance and distribution have been implicated in numerous disease etiologies. However, efforts to map histone PTMs in limited samples and single cells, such as rare primary immune cells and clinical samples, have been hindered by the lack of high-quality antibodies. To meet this need, EpiCypher is developing a novel antibody development pipeline to create ultra-efficiency antibodies that enable low and single cell genomic mapping assays.

PI_NAMEs: JOHNSTONE, ANDREA LYNN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Antibodies;Antibody Specificity;assay development;Bar Codes;Binding;Biological Assay;Cells;Characteristics;Chromatin;Clinical;cross reactivity;Data;Development;Disease;DNA;drug discovery;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenomics;Epitopes;Etiology;Exhibits;Feedback;Genomics;Goals;Histones;Immune;Immunization;Immunize;Immunologics;Immunology;improved;in vivo;innovation;Laboratories;manufacture;manufacturing scale-up;Maps;Mediating;multiplex assay;next generation;Noise;novel;novel strategies;Nucleosomes;Oryctolagus cuniculus;Peptides;Phase;phase 2 study;Population;Post-Translational Protein Processing;Protocols documentation;Reagent;Recombinant Antibody;Recombinants;Research;Research Project Grants;Sampling;screening;Signal Transduction;single cell genomics;Site-Directed Mutagenesis;Specificity;Technology;Testing;three dimensional structure;tool;Validation

PROJECT_TITLE: Development of ultra-efficient antibodies for single cell mapping applications


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Male sex workers (MSW), or men who exchange sex for money, drugs, or other items of value with other men, are at exceptionally high risk for HIV infection, and many are ideal candidates for pre-exposure prophylaxis (PrEP) – an effective biomedical intervention for reducing HIV transmission – but use in this population has been essentially nonexistent. Currently, HIV prevention efforts for MSWs are limited, with no existing evidenced-based PrEP interventions for this population. A successful theoretically-grounded intervention that addresses the unique individual, interpersonal and contextual challenges to PrEP uptake and optimal adherence has the potential to decrease HIV incidence among MSWs and reduce forward transmission to their clients and partners.

PI_NAMEs: BIELLO, KATIE BROOKS (contact);CHAN, PHILIP ANDREW;MIMIAGA, MATTHEW JAMES

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adherence;Affect;AIDS prevention;Anal Sex;Appointment;Area;arm;Behavioral;Bisexual;Caring;Case Management;Client;Clinic;Cognitive Therapy;Collaborations;community partners;comorbidity;comparison intervention;Complementary therapies;condomless anal sex;Cost Analysis;cost effectiveness;cost estimate;Cost Savings;Counseling;County;Data;Decision Making;design;Development;Discrimination;drug use behavior;Economics;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Empathy;Employment;Epidemiology;Ethnic Origin;Evaluation;evidence base;experience;Female;Focus Groups;follow up assessment;Funding;Gays;Hair;Health behavior;Healthcare;Heterosexuals;high risk;high risk population;HIV;HIV Infections;HIV risk;Housing;Imprisonment;improved;Incidence;Individual;Informal Social Control;Injecting drug user;interest;Intervention;intervention cost;intervention effect;Interview;Life;Longitudinal cohort study;Los Angeles;male;male sex worker;Manuals;Mathematical Model Simulation;Measures;Mediator;Medical;men;men who have sex with men;Mental Depression;Meta-Analysis;Modeling;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;National Institute of Mental Health;Needs Assessment;Oral;Participant;peer;Pharmaceutical Preparations;pill;pilot test;Population;Population Intervention;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention program;Problem Solving;Provider;psychosocial;Publishing;Qualitative Research;Race;Randomized;Randomized, Controlled Trials;Research;Research Design;Rhode Island;Risk;Risk Factors;Sampling;satisfaction;Secure;Self Efficacy;Self-reflection;sex;Sexual Partners;skills;skills training;social;Social Work;Specific qualifier value;standard of care;Subgroup;Substance Addiction;substance use;Substance Use Disorder;Technology;Tenofovir;Testing;Text Messaging;theories;Time;transactional sex;transmission process;treatment arm;United States;United States National Institutes of Health;uptake;Urinalysis;Vagina;Victimization;Work

PROJECT_TITLE: Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Essential tremor is a common neurological disorder that has been linked to an increased risk of developing dementia. A large gap remains in the understanding of neuroanatomical correlates of cognitive changes in essential tremor, particularly whether they represent cerebellar dysfunction alone or potentially more widespread neurological processes, such as those seen in age-related neurodegenerative disorders like Alzheimer’s disease. The proposed study will examine biomarkers (i.e., neuroimaging, plasma) in individuals with essential tremor in an effort to better understand the link between essential tremor and cognitive dysfunction.

PI_NAMEs: RATAJSKA, ADRIANNA MARTA (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;Age;age related;age related neurodegeneration;Alzheimer's Disease;Area;base;Bilateral;Biological Markers;Brain;Cerebellar Diseases;Cerebellum;Clinical;Cognition;Cognitive;cognitive change;Cognitive deficits;cohort;computerized data processing;Data;Data Analyses;Deep Brain Stimulation;Dementia;dementia risk;Deposition;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dimensions;disability;Disease;Doctor of Philosophy;Elderly;Environment;epidemiology study;Essential Tremor;executive function;Family;Glial Fibrillary Acidic Protein;Goals;Heterogeneity;Hippocampus;Image;imaging approach;Impaired cognition;in vivo;indexing;Individual;Infrastructure;innovation;interest;Kinetics;Language;Light;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medial;Memory;Mentors;motor disorder;multimodality;Nature;Nerve Degeneration;Nervous System Disorder;neural;neural correlate;Neuroanatomy;Neurocognitive;neurofilament;neuroimaging;Neurologic Process;neuromechanism;neuropathology;non-demented;older adult;Operative Surgical Procedures;Patients;peer;Persons;Phenotype;Plasma;Posture;predictive marker;Prefrontal Cortex;Process;Productivity;Professional Competence;Programming Languages;programs;Research;Resources;Risk;Sampling;skills;Statistical Computing;Subgroup;System;tau Proteins;tau-1;Techniques;Thalamic structure;Training;Tremor;Water

PROJECT_TITLE: Cognition in Essential Tremor: A Neuroimaging and Biomarker Study


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Eczema / Atopic Dermatitis;Genetics;Human Genome;Psoriasis

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Genetic variants outside protein-coding genes can control the expression of genes important for the development of many human diseases, with specific variants linked to increased risk of specific diseases. This proposal will define the regulatory variants in selected human skin diseases and characterize how they dysregulate gene expression. This effort is designed to help understand the principles whereby inherited variants predispose to disease. 1

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Affect;Architecture;Atopic Dermatitis;Bar Codes;Binding;Biochemical;Biological Assay;Cell Line;Cells;ChIP-seq;Chromatin;Chromosomes;Chronic small plaque psoriasis;Code;combinatorial;Complement;Couples;CRISPR screen;Cutaneous;Dependovirus;design;Detection;Development;Differentiated Gene;Diploidy;Disease;Dissection;DNA;DNA Binding;DNA Sequence;Enhancers;Epidermis;Gene Expression;gene-editing approach;Genes;Genetic;genetic approach;Genetic Transcription;genetic variant;genome wide association study;Genomics;Histones;Human;human disease;human tissue;hybrid gene;Hybrids;Impairment;Inflammatory;Inherited;interest;keratinocyte;Knock-out;Lasers;Link;Maps;Mediating;Methods;Molecular Conformation;Natural regeneration;Nature;Nucleotides;Pathogenesis;Pathogenicity;Permeability;Phenotype;promoter;Proteins;Proteomics;prototype;Quantitative Trait Loci;Reporter;Risk;RNA;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;Skin;skin disorder;Skin Tissue;skin xenograft;Tissues;transcription factor;Validation;Variant

PROJECT_TITLE: Regulatory Variants in HUMAN SKIN DISEASES

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative (Public relevance statement) This project addresses the need to improve identification of developmental language disorders in children who speak a language other than English at home. We will investigate two novel approaches to language assessment that both aim to measure a child’s underlying language- learning ability. By rigorously evaluating these assessment approaches, including how well they predict English language growth over time and how well they index risk for language disorder, we will advance clinical and theoretical knowledge of language assessment with minority language learners (i.e., those who speak languages such as Spanish, Somali, Hmong, or Karen).

PI_NAMEs: EBERT, KERRY DANAHY (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 4 year old;6 year old;academic program;Address;Affect;Assessment tool;Attention;attentional control;bilingualism;Child;Child Language;Clinical;clinical implementation;Clinical Services;cohort;Complement;diagnostic accuracy;disorder risk;educational atmosphere;Educational process of instructing;English Language;Environment;experience;Exposure to;Future;Growth;high risk;Home;Household;improved;indexing;innovation;interest;Interview;Knowledge;Language;Language Development;Language Development Disorders;Language Disorders;language impairment;language outcome;Learning;learning ability;Linguistics;longitudinal design;Measures;Methods;Minority;Modeling;nonEnglish language;novel;novel strategies;Parents;peer;Population;Process;processing speed;Property;Psychometrics;recruit;response;Risk;Sampling;School-Age Population;Schools;Sensitivity and Specificity;Services;Shapes;Short-Term Memory;skills;Spanish;Spanish/English;Structure;Target Populations;teacher;Testing;Time;tool;Underserved Population;Validity and Reliability;Work

PROJECT_TITLE: Reliability and Validity of Dynamic and Processing-based Assessments for Language in Diverse Bilingual School-age Children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Urologic Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE  Recent rise in the levels of antimicrobial resistance is highly alarming. Clinicians broadly use Ciprofloxacin, but resistance level to it is spreading at a high rate, specifically among Escherichia coli that cause urinary tract infections in community or hospital settings. We will study alternative mechanisms of emergence, transmission and spread of the Ciprofloxacin resistance by E. coli strains.

PI_NAMEs: SOKURENKO, EVGENI VENIAMINOVIC (contact);TRAXLER, BETH A

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Antibiotic Resistance;Antimicrobial Resistance;Bacterial Chromosomes;bacterial resistance;bactericide;Bioinformatics;Chromosomes;Ciprofloxacin;Clinical;Code;Communities;Complex;Coupled;Development;Distant;DNA;DNA Gyrase;DNA Topoisomerase IV;Ensure;Enterobacteriaceae;Escherichia coli;Event;Evolution;fluoroquinolone resistance;Fluoroquinolones;Gene Transfer;Genes;Genetic Recombination;homologous recombination;Horizontal Gene Transfer;Hospitals;In Vitro;in vivo;Infection;Length;Maintenance;Medicine;minimal inhibitory concentration;Molecular;Molecular Evolution;Multi-Drug Resistance;Mutation;Nature;new pandemic;pandemic disease;pathogen;Physiological;Plasmids;Positioning Attribute;Probability;progenitor;Proteins;quinolone resistance;Recombinants;Resistance;Resistance to infection;restraint;Structure;success;Time;transmission process;Traveler's diarrhea;urinary;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Work

PROJECT_TITLE: Mechanism of the Fluoroquinolone Resistance Acquisition in Enterobacteria

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PI_NAMEs: ANDERSON, ADAM K;DEROSA, EVE  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acetylcholine;age difference;age related;age related changes;age related decline;Aging;aging related;Alzheimer's Disease;Amyloid beta-Protein;arterial spin labeling;Attention;basal forebrain;basal forebrain cholinergic neurons;base;Behavioral;Biological Markers;Brain;Cell Nucleus;Cells;Central Nervous System;Cerebrovascular Circulation;cholinergic;Clinical;clinically significant;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive control;cognitive function;cognitive performance;cognitive reappraisal;cost;Data;Deafferentation procedure;Dementia;Deposition;digital;Digital biomarker;Early Diagnosis;early screening;Elderly;experimental study;Female;Functional Magnetic Resonance Imaging;healthy aging;Heart;Heart Rate;heart rate variability;Hippocampus;Human;Immunoglobulin G;Impaired cognition;Impairment;indexing;Intervention;Lesion;life span;Limbic System;male;Masks;Measures;Mediating;middle age;Mind;Modeling;Monitor;Neocortex;neural;Neuroanatomy;neurochemistry;Neurocognitive;neurocognitive disorder;neuroimaging;Neuropsychology;neuroregulation;Neurotransmitters;normal aging;older adult;Pathologic;pathological aging;Performance;Peripheral;Phase;Physiologic pulse;Positron-Emission Tomography;Prefrontal Cortex;preservation;Production;progenitor;Proxy;rate of change;Rattus;Regulation;Research;response;Rest;Role;Sampling;Serum;Signal Transduction;Site;Structure;System;Task Performances;tau Proteins;Testing;trait;Vagus nerve structure;young adult

PROJECT_TITLE: Basal Forebrain connections to the heart and mind in healthy aging


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Carcinoma–associated fibroblasts (CAFs) play a critical role in colorectal tumor progression. In this project, I will investigate the pathological origin of CAFs and leverage my finding to develop treatments to suppress the traits of tumor microenvironment promoting metastasis. Colorectal cancer mouse models will be used to evaluate the efficacy of the new treatments.

PI_NAMEs: JUNG, WEI-HUNG  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Affect;anti-cancer;Antineoplastic Agents;Architecture;Autologous Transplantation;Biochemical;biophysical properties;cancer cell;Cancer Etiology;Cancer Model;cancer type;Carcinoma;Cell Therapy;Cessation of life;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Coin;Collagen;Colon;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Cross-Linking Reagents;crosslink;cytokine;Dendritic cell activation;Deposition;Dermal;Development;Diffuse Pattern;Diffusion;Doctor of Philosophy;Drops;Drug Delivery Systems;Early Diagnosis;effective therapy;efficacy evaluation;efficacy testing;Engineering;Enzymes;Etiology;exosome;Extracellular Matrix;extracellular vesicles;Fibroblasts;Genes;Genetic Engineering;genipin;Genome;Glutaminase;Health;Implant;improved;improved outcome;In Vitro;in vivo;Integrins;Invaded;Lead;Length;Link;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;mechanical force;Mechanics;Mediating;men;metastatic colorectal;mouse model;Mus;Neoplasm Metastasis;Pathologic;Pathway interactions;Phenotype;Play;Postdoctoral Fellow;Prognosis;promoter;Proteomics;Research;Research Project Grants;Role;screening;Signal Pathway;spheroids;Squamous cell carcinoma;Stromal Cells;Survival Rate;System;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissues;Training;trait;Translating;Transportation;Treatment Efficacy;treatment strategy;tumor;tumor microenvironment;tumor progression;viscoelasticity;Woman

PROJECT_TITLE: Characterizing the effects of extracellular matrix viscoelasticity on dendritic cell activation


ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will define new mechanisms for the imitation and propagation venous thrombosis. Specifically, the project will examine how factors that control protease activated receptor 4 (PAR4) signaling leads to venous thrombosis. The project is relevant to the NIH’s mission to identify and characterize the underlying biological mechanisms that have the potential to become dysregulated in pathological states.

PI_NAMEs: NIEMAN, MARVIN THOMAS (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Affect;Alleles;Animal Model;antagonist;Binding Sites;Biological;Biophysics;Blood;Blood flow;Blood Platelets;Collaborations;Complex;Complication;Data;Development;Disease;drug development;endothelial dysfunction;Endothelium;experience;extracellular;Generations;Genetic Polymorphism;genome wide association study;Goals;Health;Human;in vivo;in vivo Model;Individual;inhibitor;Injury;innovation;insight;Learning;Ligand Binding;Meta-Analysis;Microfluidic Microchips;Mission;Molecular;mouse model;mouse protease-activated receptor 4;Multicellular Process;Mutate;Mutation;neutrophil;Pathologic;Pathway interactions;Persons;pharmacologic;Physiological;platelet function;prevent;Process;programs;protease-activated receptor 3;protease-activated receptor 4;Proteinase-Activated Receptors;Public Health;Pulmonary Embolism;Qualifying;Relative Risks;Research;Risk Factors;Risk Reduction;Role;Serine;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Structure;Testing;therapeutic target;Thrombin;Thrombosis;Thrombus;Translating;United States National Institutes of Health;validation studies;Variant;Venous;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: The role of protease activated receptors on platelets

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative: This study will address a need for motivational strategies to achieve therapeutic levels of task repetition in upper extremity rehabilitation post-stroke. To do so, we will characterize the motor, affective, physiological and neural effects of music improvisation in stroke survivors. The findings from this study will contribute to a framework for optimizing music-based interventions for upper extremity rehabilitation post-stroke.

PI_NAMEs: PALUMBO, ANNA M (contact)

PROJECT_TERMS: Accelerometer;Adult;Affect;Affective;Animal Model;Area;Arousal;Attention;Behavioral;Brain;Brain region;Brain-Derived Neurotrophic Factor;chronic stroke;Clinical;clinical practice;Cognitive;conventional therapy;Data;design;disability;Elements;Emotional;Emotions;environmental enrichment for laboratory animals;Exercise;experience;Fatigue;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Goals;hemiparesis;Impairment;improved;Individual;instrumentation;Intervention;intrinsic motivation;Link;Measures;Mental Depression;Molecular;Motivation;Motor;Motor Activity;Motor Cortex;Motor output;motor recovery;Movement;Music;Music Therapy;neural;neural correlate;Neurological outcome;neuromechanism;Neuronal Plasticity;Outcome;Participant;Patient Self-Report;Physiological;Play;pleasure;Population;post stroke;Prefrontal Cortex;Recovery;Rehabilitation therapy;Reporting;response;Rewards;Sensory;social;Social Environment;Specific qualifier value;Stroke;stroke hemiparesis;stroke intervention;stroke patient;stroke rehabilitation;stroke survivor;Structure;Surveys;Survivors;Testing;Therapeutic;Upper Extremity;Veins;Work;World Health Organization

PROJECT_TITLE: Optimizing Music-Based Interventions for Stroke Rehabilitation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project aims to develop advanced alternative payment models to promote both use of active surveillance for favorable-risk prostate cancer and its quality (i.e., confirmatory testing). These payment models will help align financial incentives for payers and providers, reduce unwarranted variation in surveillance implementation, and shift more patients to appropriate use of active surveillance for favorable-risk prostate cancer.

PI_NAMEs: HOLLENBECK, BRENT K.;SHAHINIAN, VAHAKN B (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Achievement;Address;Adverse effects;aggressive therapy;Androgens;Authorization documentation;Biopsy;Blue Cross;Blue Shield;bundled payment;care costs;Caring;Characteristics;Clinical;Communities;cost;Cost Savings;curative treatments;Data;deprivation;Development;Diagnosis;Disease;Disincentive;disorder risk;Ensure;financial incentive;genomic signature;Goals;Growth;health care delivery;Healthcare;Image;implementation measures;improved;Incentives;Intensity-Modulated Radiotherapy;interest;Intervention;Interview;Life Expectancy;Literature;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medicare;meetings;men;Methods;Michigan;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Movement;Natural History;Operative Surgical Procedures;overtreatment;Patient-Focused Outcomes;Patients;payment;Performance;Physicians;Policies;population health;Practice Management;prevent;Privatization;prostate cancer risk;Prostate Cancer therapy;Provider;provider behavior;Radiation therapy;Registries;Remunerations;response;Review Literature;Risk;Savings;Sexual Dysfunction;Structure;surveillance strategy;Symptoms;System;Testing;Time;treatment pattern;tumor;tumor progression;Uncertainty;urinary;Urologic Surgical Procedures;Urologist;Urology;Variant

PROJECT_TITLE: Aligning financial incentives to promote rational use of active surveillance for prostate cancer

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Parkinson’s disease is one of the fastest growing neurodegenerative diseases and is often accompanied by progressive, eventually debilitating cognitive decline to dementia. The goal of the proposed project is to determine whether a more comprehensive approach for assessing neurobiological dysfunction will better predict current and future cognitive disturbance. Broadly, improving the assessment of cognitive risk could inform both clinical prognosis for individuals with PD and allow for a more targeted selection of participants into experimental trials aiming to slow impending cognitive decline.

PI_NAMEs: KENNEY, LAUREN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Accounting;Address;Affect;Age;Age-associated memory impairment;Aging;alpha synuclein;Amyloid beta-Protein;Area;Astrocytes;Biological Markers;Brain;C-reactive protein;career;Categories;cerebrovascular;Cerebrovascular Disorders;clinical prognosis;Cluster Analysis;Cognition;Cognitive;cognitive change;cognitive performance;cohort;Competence;cytokine;Data;Dementia;Disease Progression;Doctor of Philosophy;Education;Environment;Equation;Evaluation;Executive Dysfunction;executive function;experience;falls;follow-up;Functional disorder;Future;Gender;Goals;Grant;Homocysteine;hypoperfusion;Idiopathic Parkinson Disease;Impaired cognition;improved;Individual;Interleukin-6;Linear Regressions;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Memory;Memory Loss;Mentors;Methodology;Methods;Modeling;Motor;motor symptom;Movement Disorders;Neurobiology;Neurodegenerative Disorders;neuroinflammation;neuropathology;non-motor symptom;Parkinson Disease;Participant;patient prognosis;Performance;Persons;Phenotype;Plasma;precision medicine;Predictive Factor;Predictive Value;Price;Productivity;Professional Competence;programs;Psychometrics;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Sampling;sex;skill acquisition;stroke risk;Subgroup;System;tau Proteins;TNF gene;Training;United States;United States National Institutes of Health;Variant;Visit;White Matter Hyperintensity

PROJECT_TITLE: Brain Drivers, Cognition, and Parkinson's Disease: A Psychometric Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Transcranial magnetic stimulation (TMS) uses magnetic fields sent from a “wand” placed on the head to safely treat brain disorders without drugs. However, existing TMS devices have limited ability to stimulate the brain precisely and doing so requires expensive equipment and uncomfortable headgear. This project will develop a cheaper and more comfortable tool to position precisely the TMS wand based on tracking of the patient’s face, which could improve the patients’ experience and clinical outcome. 1

PI_NAMEs: DI MARTINO, JUAN MATIAS ;PETERCHEV, ANGEL V (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Algorithms;Anatomy;Atlases;Brain;Brain Diseases;Brain region;Clinical;clinical practice;Clinical Research;Clinical Trials;Computer Models;Computer Vision Systems;Consumption;cost;Data;Dedications;Devices;efficacious intervention;Elasticity;Electromagnetics;Equipment;experience;Face;Functional Magnetic Resonance Imaging;Goals;Goggles;Head;healthy volunteer;human subject;improved;Individual;Libraries;Light;magnetic field;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Minority;Modeling;Movement;MRI Scans;Neuronavigation;new technology;noninvasive brain stimulation;Obsessive-Compulsive Disorder;Optics;Outcome;Patients;Pharmaceutical Preparations;Positioning Attribute;predicting response;Procedures;Process;Protocols documentation;Reproducibility;Research;response;Sampling;Scalp structure;Scanning;Skin;smoking addiction;Speed;Subject Headings;success;Surface;synergism;System;Techniques;Technology;Testing;Time;tool;Transcranial magnetic stimulation;Treatment Efficacy;trend;Visible Radiation

PROJECT_TITLE: Accurate, low-cost, trackerless neuronavigation for transcranial magnetic stimulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Age-associated cognitive decline is a significant public health challenge with no effective treatments that will only have increased disease burden with an aging population. Studies of age-associated changes in the gut microbiome and its effects on disease, especially cognitive decline, are limited. Determining the role of the microbiome in age-associated cognitive decline has the potential to identify novel mechanisms and therapeutic targets to combat aging.

PI_NAMEs: COX, TIMOTHY  (contact)

PROJECT_TERMS: Ablation;Affect;Afferent Neurons;Age;age effect;age related;age related changes;age related decline;Age-associated memory impairment;aged;Aging;aging mechanism;aging population;Alzheimer's Disease;Antibiotic Therapy;Antibiotics;autism spectrum disorder;Bacteria;Behavior;Body System;Brain;Brain region;Brain Stem;burden of illness;Capsaicin;Cell Nucleus;Cells;Central Nervous System;Cholecystokinin;Chronic;Cognition;Cognitive deficits;cognitive testing;Collection;combat;Communication;comparison control;Complex;cost;Data;Dementia;designer receptors exclusively activated by designer drugs;Digestion;Disease;Dose;Economics;effective therapy;Emotional;Enteric Nervous System;Exhibits;experience;experimental study;fecal transplantation;Feces;fitness;Future;Gastrointestinal tract structure;Genes;Genetic;germ free condition;Germ-Free;glucagon-like peptide 1;gut microbiome;gut-brain axis;Hippocampus;Histology;Homeostasis;Hormonal;Impaired cognition;Impairment;Injections;insight;Institution;International;Learning;Life Expectancy;Link;Living Standards;Maps;Medial;Mediating;Memory;memory encoding;Memory Loss;Mental Depression;Mentorship;Metabolism;metagenomic sequencing;microbiome;microbiome analysis;microbiome components;microbiome composition;microbiome sequencing;microorganism;Modern Medicine;Mus;Nerve Degeneration;neural circuit;Neurologic;Neurons;Neurotoxins;Nodose Ganglion;novel;novel therapeutics;Obesity;object recognition;old mice;Organism;Pathogenicity;Pathway interactions;Pennsylvania;Performance;Persons;Phenotype;Physicians;Play;Positioning Attribute;prevent;Process;Public Health;Rattus;Reproducibility;Research;resilience;response;Ribosomal DNA;Role;Sampling;Scientist;Seminal;Sensory;Signal Transduction;skills;social;Stimulus;success;Synapses;System;Tamoxifen;Testing;therapeutic target;Time;tool;Training;University resources;Vagus nerve structure;Virginia

PROJECT_TITLE: Microbiome Contributions to Age-Associated Cognitive Decline


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE About 75-100 million Americans are estimated to have fatty liver disease, which can lead to nonalcoholic steatohepatitis (NASH) and liver fibrosis. Detection of liver steatosis is important for management of NASH, diabetes, and cardiovascular disease. In this study, we will develop and test a new ultrasound technology for safe, cost-effective, convinient, and accurate evaluation of liver steatosis.

PI_NAMEs: CHEN, SHIGAO  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Affect;Agreement;Algorithms;American;attenuation;Benchmarking;Binding;Biological Markers;Calibration;Cardiovascular Diseases;Categories;Classification;Clinical;Clutterings;cost;cost effective;density;Detection;detection sensitivity;Development;diabetes management;Diabetes Mellitus;Diagnosis;Evaluation;Exclusion;Family;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibrosis;follow-up;Frequencies;Guidelines;Hepatology;Image;imaging detection;improved;Intervention;Liver;Liver Cirrhosis;Liver Fibrosis;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Modernization;new technology;Noise;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Outcome;patient population;Patients;Penetration;Performance;Phase;point of care;Populations at Risk;Protons;prototype;Random Allocation;Recommendation;Reference Standards;Regression Analysis;Reproducibility;rib bone structure;Risk;ROC Curve;Scanning;screening;serial imaging;Serum;signal processing;Signal Transduction;sound;Specificity;Speed;Staging;statistics;Technology;Testing;Time;ultrasound;wireless;X-Ray Computed Tomography

PROJECT_TITLE: Hepatic Steatosis Quantification with Ultrasound

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Chronic Obstructive Pulmonary Disease;Digestive Diseases;Genetics;Liver Disease;Lung;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE To overcome the scarcity of donor livers for transplantation, hepatocytes generated from human induced pluripotent stem cells (hiPSC) could provide an unlimited supply of cells to treat liver diseases with cell therapy; however, preparing hiPSC-derived hepatocyte-like cells (HLC) that can repopulate diseased livers remains a challenge and a major gap which the current proposal targets. Given the known immaturity and poor survival of HLCs in vivo in comparison to primary cells, we propose that engineering HLCs to express key regenerative and maturation factors represents a potential strategy to overcome the obstacles of HLC therapies. This approach includes HLCs engineered to express maturation factors and activate mitogen pathways in combination with the use of clinically safe nucleoside-modified mRNA technology, with the goal to develop successful HLC-based treatment for liver disease.

PI_NAMEs: SMITH, ANNA R. (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Address;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;alternative treatment;Autologous;Award;Blood;BMP4;CEBPA gene;Cell Culture Techniques;Cell Cycle;Cell Death;Cell Line;Cell Maturation;Cell Survival;Cell Therapy;Cell Transplantation;Cells;cellular engineering;Cirrhosis;Clinical;COVID-19 vaccine;Culture Media;Data;directed differentiation;Disease;disease model;Doxycycline;Encapsulated;Engineering;Engraftment;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Genes;Genetic Diseases;Genetic Transcription;Goals;Graft Rejection;Growth;Growth Factor;Growth Factor Receptors;Hepatic;Hepatocyte;hepatocyte engraftment;Hepatocyte transplantation;HGF gene;Human;Human Engineering;human induced pluripotent stem cells;Immune;improved;In Vitro;in vivo;induced pluripotent stem cell;inducible gene expression;inhibitor;Injections;intravenous injection;Ligands;lipid nanoparticle;Liver;Liver Cirrhosis;Liver diseases;liver function;liver transplantation;Lung;Messenger RNA;MET gene;Mitogen Receptors;Mitogens;mouse model;Mus;Mutation;Nucleosides;Organ Transplantation;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptide Hydrolases;Physiological;Point Mutation;polymerization;Polymers;preconditioning;prevent;Production;Proliferating;Protease Inhibitor;Proteins;Pulmonary Emphysema;receptor;regenerative;Risk;RNA vaccine;Serum;Specific qualifier value;stem cell therapy;System;Technology;Testing;Therapeutic;tool;Toxic effect;transcription factor;Transcription Factor 3;Transfection;Transgenic Mice;Transplantation

PROJECT_TITLE: Primary hepatocyte and engineered iPSC-derived hepatocyte-like cell transplantation to treat alpha-1 antitrypsin deficiencyassociated liver disease


NIH_SPENDING_CATS: Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORVALLIS

ORG_DEPT: BIOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Leptin is a hormone that acts on multiple organs, including the immune system and bone. The proposed research tests the hypothesis that leptin, acting on subsets of immune cells, is a key positive contributing factor to normal bone accrual and turnover balance, but also enhances bone loss caused by chronic inflammation. This knowledge is important because failure to accrue sufficient bone mass and bone loss due to chronic inflammation contribute to bone fractures in the elderly.

PI_NAMEs: IWANIEC, URSZULA T (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: adipokines;Adoptive Transfer;Adult;Aging;aging related;B-Lymphocytes;Binding;bone;Bone Growth;bone loss;bone mass;bone metabolism;bone quality;bone turnover;Calvaria;Cell Lineage;Cell Proliferation;Cells;Central Nervous System;chemokine receptor;Chronic;Complex;Coupling;Data;db/db mouse;Disease;Elderly;Elements;energy balance;Energy Intake;Energy Metabolism;Engraftment;Equilibrium;Failure;Female;Fracture;Goals;Growth;Health;Hematopoietic;Hematopoietic stem cells;Homeostasis;Hormones;Immune;immune reconstitution;Immune signaling;Immune system;Immunoglobulin M;Inflammation;Inflammatory;insight;Interruption;Knowledge;Leptin;leptin receptor;Lymphoid Cell;Maintenance;male;mast cell;Mediating;Membrane;Modeling;Molecular;monocyte;Mus;Myeloid Cells;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Organ;Osteoblasts;Osteoclasts;Osteolysis;particle;Pathologic;Pathology;Peripheral;Physiological;Play;Polyethylenes;prevent;Proto-Oncogene Protein c-kit;receptor;recruit;Regulation;Regulatory Element;Research;Role;Signal Transduction;skeletal;Skeletal system;skeletal tissue;Skeleton;Strategic Planning;T-Cell Receptor;Testing;therapeutic target;therapy development;tool

PROJECT_TITLE: The Role of Leptin in Inflammation-Driven Bone Loss

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

PHR: Project Narrative Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, we will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology.

PI_NAMEs: KAVANAUGH, BRIAN  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescent;Area;Award;Behavioral;brain based;brain magnetic resonance imaging;career;Cerebral cortex;Child Psychiatry;Childhood;Clinical;clinical predictors;Clinical Research;cognitive control;Collection;Complex;computational neuroscience;Computer Models;Coupling;Data;Dedications;design;Diagnostic;Double-Blind Method;Electroencephalography;Electrophysiology (science);executive function;Feeds;Foundations;functional outcomes;Goals;improved;Inferior;Interneurons;Intervention;K-Series Research Career Programs;Left;Lobule;Maintenance;Measures;Memory impairment;memory process;Mentorship;Methods;model design;Modernization;multimodality;National Institute of Mental Health;neocortical;neural;neural model;Neuroanatomy;Neurocognitive Deficit;neuromechanism;Neurons;Neuropsychology;neuroregulation;noninvasive brain stimulation;novel;novel strategies;optimal treatments;Parietal;Parietal Lobe;Participant;patient oriented research;Pattern;Performance;Periodicity;Physiologic pulse;Prefrontal Cortex;primary outcome;Process;Psychopathology;Randomized;Research;Research Personnel;Role;Sampling;Scalp structure;Short-Term Memory;Signal Transduction;skills;Stimulus;Technology;Training;Translating

PROJECT_TITLE: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Pediatric

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project employs state-of-art genetic models and organoid culture to determine the contribution of the yes- associated protein 1 (YAP) to pediatric eosinophilic esophagitis (EoE). This study will advance our understanding of the pathophysiology of pediatric EoE and provide potential therapeutic targets.

PI_NAMEs: BAILEY, DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Albumins;Basal Cell;Basal Cell Hyperplasia;Binding Sites;Biological Assay;Biology;Biopsy;career;career development;Cell Nucleus;Cell Separation;Cellular biology;Child;Childhood;chromatin immunoprecipitation;Chronic;cytokine;Data;Development;Developmental Biology;Disease;disease mechanisms study;early onset;Environment;Eosinophilic Esophagitis;Epithelial Cells;epithelial stem cell;Epithelium;Esophageal Diseases;Esophageal Tissue;Esophagus;experience;experimental study;Flow Cytometry;Foundations;Functional disorder;Future;gain of function;Gastroenterologist;Genetic Models;Genetic Transcription;Goals;healthcare burden;Histologic;Human;Hyperplasia;Immune;Immunology;in silico;in vitro Assay;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;innovation;insight;Interleukin-13;Interleukin-13 Overexpression;K-Series Research Career Programs;knock-down;loss of function;Luciferases;Mediating;Mediator;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mouse model;multidisciplinary;Mus;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Organoids;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Physicians;potential biomarker;pre-clinical;programs;Proliferating;Proteins;Research;research and development;Research Design;Research Proposals;Role;Scientist;Signal Pathway;Signal Transduction;skills;small hairpin RNA;STAT6 gene;stem cell biology;System;Testing;therapeutic target;Training;Transcription Initiation Site;Translating;Universities;Verteporfin;Weaning;Work;young adult

PROJECT_TITLE: Molecular Mechanisms of Reactive Epithelial Changes in Pediatric Eosinophilic Esophagitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The incidence of inflammatory bowel disease (IBD) is rising worldwide, with an estimated 3 million cases in the United States alone. IBD poses a substantial socio-economic burden, as patients diagnosed with the illness tend to have far higher healthcare use and often go on to develop comorbidities, and many treatment options remain ineffective. This research proposal aims to identify a novel mechanism of tissue protection governing intestinal health and inflammation, which in turn will elucidate targets for therapeutic intervention to prevent or treat IBD.

PI_NAMEs: FIEDLER, BROOKE ELIZABETH (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adhesions;Antigen Presentation;antimicrobial;Architecture;Area;Award;Binding;Cell Adhesion;Cell Communication;cell motility;Cell surface;cell type;Cells;Cellular biology;Chronic;Colon;Colon Carcinoma;Communication;comorbidity;Complex;Critical Pathways;cytokine;Data;Data Set;Defect;Development;Diagnosis;Diet;Disease;dysbiosis;Economic Burden;Ensure;Epithelium;FGF2 gene;Fibroblast Growth Factor;Future;Gastrointestinal tract structure;Genetic;Growth Factor;Growth Factor Receptors;gut health;gut inflammation;gut microbes;gut microbiota;Gut Mucosa;healing;Health;Healthcare;Heparan Sulfate Proteoglycan;Homeostasis;host microbiota;Human;IL17 gene;IL1R1 gene;Immune;Immune response;Immune Tolerance;Immunity;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;interleukin-22;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Investigation;Knowledge;Life Style;Link;Lymphocyte;Lymphoid Cell;Maintenance;microbial;microbiota;migration;Molecular;mouse model;Mucous Membrane;Mus;Natural Immunity;new therapeutic target;novel;novel therapeutics;Pathway interactions;Patients;Physiological;Population;Predisposition;Prevalence;prevent;Production;receptor;Regulation;repaired;Research Proposals;response;restraint;Role;selective expression;Signal Transduction;single-cell RNA sequencing;socioeconomics;Source;success;syndecan;syndecan-4;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tissue repair;Tissues;Training;transcription factor;translational study;United States;Vascular Endothelial Growth Factors;wound healing

PROJECT_TITLE: ILC3 Syndecan-4 in the Regulation of Intestinal Health and Inflammation