NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Relevance Chronic rhinosinusitis (CRS) is an inflammatory disease that has substantial impacts on patient quality of life and health care resource utilization. This proposal focuses on characterizing a unique inflammatory signature in elderly CRS patients that is driven by IL-1 and other pro-inflammatory cytokines. Analysis of patient-derived samples will be used to clarify associations between mucosal innate immunity, inflammasome activation, and the microbiome, with the potential to identify novel mechanisms of disease and new targets for treatment.

PI_NAMEs: TURNER, JUSTIN H (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Age;age difference;age group;age related;aged;Aging;aging population;alternative treatment;Antibody Therapy;Asthma;Cells;Chronic;chronic rhinosinusitis;Clinical Research;cohort;Cohort Studies;comorbidity;cytokine;Data;Data Analyses;design;Diagnostic;Disease;Elderly;Enrollment;environmental allergy;epidemiology study;Epithelium;Functional disorder;Genetic Transcription;Goals;Grant;Healthcare;human tissue;humanized monoclonal antibodies;Immune;Immune System Diseases;Immunophenotyping;In Vitro;Individual;Inflammasome;Inflammation;Inflammatory;innate immune function;Innate Immune System;insight;interest;Intervention;Ligands;Medical;microbial;microbiome;microbiota;microorganism antigen;Molecular;Mucositis;Mucous Membrane;multidimensional data;multidisciplinary;multiple omics;nasal microbiome;Natural Immunity;neutrophil;novel;older patient;Operative Surgical Procedures;pathogen;pathogenic bacteria;pathogenic microbe;Patients;Pattern;Phenotype;physical conditioning;Population;Production;prospective;Prospective cohort;Quality of life;receptor expression;receptor function;Receptor Signaling;Research Personnel;Resources;response;Risk;Role;Sampling;side effect;Sinus;Stimulus;Symptom Burden;Symptoms;Syndrome;System;Techniques;Testing;Tissue Procurements;Tissues;Toll-like receptors;Topical Corticosteroids;translational study;United States National Institutes of Health;Vulnerable Populations;working group

PROJECT_TITLE: Age-associated Innate Immune Dysfunction in Chronic Rhinosinusitis

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Immunotherapy has revealed the potential of the immune system to mediate durable tumor control via immunological memory. This proposal seeks to determine how the immune system initiates anti-tumor ‘memory’ and how cancer disrupts this process. Better understanding of the pathways underlying immune memory may direct the development of novel immunotherapy strategies to improve outcomes for patients with cancer.

PI_NAMEs: WATTENBERG, MAX  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: advanced pancreatic cancer;Agonist;Apoptosis;Area;Automobile Driving;Award;cancer immunobiology;cancer immunotherapy;Cancer Model;CAR T cell therapy;career;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Survival;cell type;Cells;Clinical;Clinical Trials;clinically relevant;conditional knockout;CRISPR/Cas technology;Cues;cytokine;Cytokine Receptors;cytotoxic CD8 T cells;Data;Dendritic Cells;Development;didactic education;Educational workshop;Effector Cell;Engineering;Environment;Functional disorder;Funding;Generations;Genetic Transcription;Goals;Human;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;immunogenic;Immunologic Memory;Immunologic Surveillance;Immunotherapy;improved;improved outcome;Infiltration;Inflammation;Inflammatory;insight;Institution;Interleukin-6;Knockout Mice;Lead;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Memory;memory CD4 T lymphocyte;memory recall;Mentors;Mentorship;Modeling;mouse model;Mus;Myelogenous;Natural Immunity;Neoplasm Metastasis;neoplastic cell;novel;Outcome;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patient-Focused Outcomes;Patients;Pennsylvania;pharmacologic;Phenotype;Physicians;Play;Population;pre-clinical;Process;Productivity;programs;Proteins;Research;Resistance;Resources;response;Role;Sampling;Scientist;Senior Scientist;Signal Transduction;STAT3 gene;Survival Rate;T-Lymphocyte;Testing;TNF gene;TNFRSF5 gene;Training;transcriptomics;Transgenic Mice;Translational Research;tumor;tumor eradication;Tumor Immunity;tumor microenvironment;Universities;Work

PROJECT_TITLE: Investigating CD4+ T cell memory in cancer immunotherapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Kidney Disease;Liver Disease;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The burden of kidney dysfunction in cirrhosis patients continues to increase; however, the tools we employ to identify a patient’s risk for acute kidney injury are limited. This proposal—through the use of a large longitudinal cohort and novel biomarkers—aims to earlier identify cirrhosis patients at risk for AKI in an effort to implement preventative strategies and reduce kidney-related morbidity and mortality.

PI_NAMEs: CULLARO, GIUSEPPE  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Age;aging population;Albumins;American;Award;Biological Markers;Biological Specimen Banks;biomarker driven;biomarker selection;biomarker validation;Biometry;Calibration;California;career;career development;Cause of Death;Cessation of life;Chronic Kidney Failure;Cirrhosis;Clinical;clinical predictors;Clinical Research;clinical risk;cohort;Collaborations;Communities;Complication;cost;Coupled;Creatine;Creatinine;Data;Data Analyses;demographics;Development;Development Plans;Discrimination;Early identification;Early Intervention;Enrollment;Equation;Etiology;Evaluation;Fibrosis;Filtration;Foundations;Future;Globulins;Glomerular Filtration Rate;Goals;Health;hemodynamics;Hepatic;Hepatology;Hospitalization;Hour;Impairment;implementation intervention;Incidence;Inflammation;Injury;Injury to Kidney;Inpatients;K-Series Research Career Programs;Kidney;kidney dysfunction;Laboratories;Lead;Leadership;Learning;Liver diseases;liver transplantation;Longitudinal cohort;Machine Learning;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Nephrons;non-alcoholic fatty liver disease;novel;novel marker;Outcome;Patient risk;Patients;Permeability;Population;post gamma-globulins;predictive tools;Prevalence;prevent;Prevention strategy;Preventive therapy;proenkephalin;programs;Property;Publications;rat KIM-1 protein;Renal function;Research;Research Personnel;Risk;risk prediction;risk stratification;San Francisco;Serum;Severities;Skeletal Muscle;skills;Statistical Data Interpretation;statistics;Structure;Supervision;support vector machine;Techniques;tool;Training;trend;United States;Universities;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: Application of Novel Biomarkers of Renal Health in Cirrhosis Patients to Stratify Risk of Acute Kidney Injury Occurrence and Reversibility

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: NATIVE AMERICAN COMMUNITY CLINIC

ORG_STATE: MN

PI_NAMEs: STATELY, ANTONY  (contact)

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: Address;African American population;Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;Area;behavioral health;cancer health disparity;Caring;Chemicals;chronic painful condition;Clinic;Clinical;Clinical Data;Collaborations;commune;Communicable Diseases;Communities;community advisory board;community based participatory research;community based research;community clinic;Community Developments;community empowerment;community engagement;Community Surveys;County;Data;data sharing;Death Rate;Dependence;Disease;Disease Outbreaks;Educational workshop;Effectiveness;empowerment;Ensure;Epidemic;Epistemology;Equity;Ethics;Event;evidence base;experience;Face;Federally Qualified Health Center;Focus Groups;Fostering;Funding;General Population;Goals;Harm Reduction;healing;Health;health care model;health disparity;health inequalities;Hepatitis C;Hepatitis C virus;HIV;HIV/HCV;Home;Homelessness;improved;Indigenous;indigenous community;Individual;Inequity;Information Systems;Infrastructure;innovation;insight;Institution;Intervention;Intervention Studies;Interview;Knowledge;Lead;Leadership;Lived experience;longitudinal dataset;Masks;Medical Staff;medication-assisted treatment;member;Mental Health;Methodology;Minnesota;Mission;Modeling;multidisciplinary;Names;National Institute of Drug Abuse;Native American community;Neighborhood Health Center;Operating System;operation;opioid epidemic;opioid use disorder;Outcome;Outcomes Research;Overdose;overdose prevention;Pain management;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Policies;Politics;Positioning Attribute;Prevention;Procedures;Process;programs;Protocols documentation;Qualifying;racial disparity;Radial;Records;Reporting;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resource Allocation;satisfaction;screening;Secure;Series;social;Substance Use Disorder;success;syndemic;System;Target Populations;Testing;Traditional Medicine;Training;treatment center;Tribes;Trust;Twin Cities;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;uptake;urban dwelling;urban Native American;Work

PROJECT_TITLE: Increasing the Capacity of a Community-Based Research Center to Address Opioid Use Disorder and Related Health Inequities in Urban American Indian Communities


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We will pursue a series of analyses to expand the insights obtained from the cross species Integrative Longevity Omics (csILO) main data set by identifying genes, transcripts and proteins that are not present or operative in different species’ genomes and but whose presence/absence is associated with species lifespan. We will then use the resulting insights to motivate drug studies in mice that target those analytes where possible.

PI_NAMEs: MILLER, RICHARD A;SCHORK, NICHOLAS JOSEPH (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age-related disease;Aging;aging process;analytical method;anti aging drug;Biological;Blood;Communities;comparative;Data;Data Aggregation;Data Set;Development;Disease;Disparate;drug discovery;Drug Targeting;Elements;epigenetic clock;Fatty acid glycerol esters;Genes;Genome;genome wide association study;geroprotector;healthy aging;Human;improved;Individual;insight;Intervention;life span;Longevity;longitudinal human study;Measures;metabolomics;Methods;Morbidity - disease rate;Mus;Muscle;novel;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;polygenic risk score;Process;protective factors;Proteins;Proteomics;Public Domains;rate of aging;Research;Research Design;Sampling;Series;Skin;Source;System;Tissues;Transcript;Work

PROJECT_TITLE: Integrative Cross Species Analysis for Longevity Drug Target Identification


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PI_NAMEs: SARAFIANOS, STEFAN G (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: activation-induced cytidine deaminase;Anti-viral Agents;Avidity;base;Binding;Binding Proteins;Binding Sites;Biochemistry;biophysical techniques;Black Box;Capsid;Capsid Proteins;Caring;Cell Nucleus;Cells;cofactor;Complex;Computer Models;Computing Methodologies;Coupled;Cryoelectron Microscopy;Cytoplasm;Data;Dependence;Development;Drug Industry;Drug resistance;Drug Targeting;Ensure;experience;Foundations;frontier;Future;Glycine;Goals;HIV;HIV-1;Hydrophobicity;improved;in silico;Infection;inhibitor;innovation;insight;Knowledge;Label;Lead;live cell microscopy;Mediating;Molecular;Molecular Biology;molecular modeling;multidisciplinary;next generation;novel;novel therapeutics;Nuclear;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Outcome;Patients;Peptides;Persons;Pharmaceutical Chemistry;Phase III Clinical Trials;Phenylalanine;Phosphotransferases;Prevention;Productivity;protein protein interaction;Proteins;Proteomics;Regulatory Pathway;Research;Resistance;resistance mechanism;Resistance profile;Route;screening;Shapes;Site;small molecule;small molecule inhibitor;structural biology;structural determinants;Structure;Surface;targeted treatment;therapeutic target;Validation;Variant;Viral;Viral Drug Resistance;virology;Virus;virus core;virus host interaction;Virus-like particle;X-Ray Crystallography

PROJECT_TITLE: Dynamics of HIV Core Interactions


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: O'DOHERTY, UNA T (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;antiretroviral therapy;Area;Award;Basic Science;Behavioral Sciences;Biomedical Research;career;Clinical;Clinical Sciences;Collaborations;collaborative environment;Communities;community advisory board;community organizations;community partners;cost;Data;Development;Educational Status;Educational workshop;electronic data;Epidemic;equity, diversity, and inclusion;experience;Faculty;Feedback;Fostering;Funding;Goals;Grant;health economics;Helper-Inducer T-Lymphocyte;Historically Black Colleges and Universities;HIV;HIV/AIDS;implementation science;innovation;Institution;instructor;interest;Investments;Joints;Journals;K-Series Research Career Programs;low and middle-income countries;Medicine;meetings;men who have sex with men;Mental Health;Mentors;Mentorship;Mission;Monitor;neutralizing antibody;next generation;novel;outreach;Pediatric Hospitals;Pennsylvania;Persons;Philadelphia;Postdoctoral Fellow;pre-doctoral;pre-exposure prophylaxis;Principal Investigator;Process;programs;Public Health;Publishing;recruit;Request for Applications;Research;Research Personnel;Research Priority;Resources;response;Schools;Scientist;Series;Sexually Transmitted Diseases;skills;Social Policies;Strategic Planning;Study Section;synergism;System;Talents;Targeted Research;Time;tool;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;user-friendly;Work;working group

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Emory prepares physician scientists to tackle health promotion, disease treatment and the pursuit of research- intensive careers. We offer research training in the biomedical sciences, biomedical engineering (Emory/GA Tech joint program), public health and social sciences (such as anthropology and sociology) to diversify the physician scientist training force and enhance early appreciation of the power of multidisciplinary approaches. Clinical training across multiple sites that include Grady Memorial (level I trauma/safety net hospital), Emory University Hospital Midtown (urban community hospital), the Atlanta VA Medical Center (serving Veterans across northeast GA), Wesley Woods (geriatric hospital), and Children’s Healthcare of Atlanta cultivates appreciation for the specific needs of diverse patient populations.

PI_NAMEs: YUSTEIN, JASON  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Social hierarchies, which are comprised of lower-ranking subordinate individuals and higher-ranking dominant individuals, are essential for maintaining stability in humans and other species; however, the neural and molecular mechanisms that regulate a subordinate social rank and its associated behaviors are unclear. The proposed research will use state-of-the-art tools in gene sequencing and genome editing to identify the genes and cell types in the brain that govern subordinate social status and assess the roles of androgens and serotonin in regulating subordinate behavior in an African cichlid fish Astatotilapia burtoni. Given that all vertebrates have androgens, serotonin, and similar genes that regulate behavior, this work will elucidate basic biobehavioral and genetic mechanisms underlying subordination that can be further explored in other animals, including humans.

PI_NAMEs: MUNLEY, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: African;Aggressive behavior;Androgen Receptor;androgenic;Androgens;Animals;base;Behavior;Behavioral;Behavioral Paradigm;Binding;biobehavior;Brain;cell type;Cells;Cichlids;CRISPR/Cas technology;Cues;Data;Dominant Genetic Conditions;Exhibits;Fishes;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;genome editing;Growth;Human;Hypothalamic structure;Individual;insight;Laboratories;male;mating behavior;Measures;Methods;model organism;Molecular;mutant;Nature;neural;neural circuit;neurobiological mechanism;neuromechanism;Neuromodulator;Neurophysiology - biologic function;Neurosecretory Systems;Neurotransmitters;novel;Partner in relationship;Pattern;Physiological;Process;Production;receptor;Receptor Signaling;Regulation;reproductive function;Research;response;Role;Serotonin;Serotonin Receptor 5-HT1A;Shapes;Signal Transduction;single nucleus RNA-sequencing;social;Social Behavior;Social Dominance;Social Hierarchy;Social status;steroid hormone;Steroids;System;Taxes;Technology;Testing;Testis;tool;trait;Vertebrates;Work

PROJECT_TITLE: Neural and molecular control of subordinate social status in a cichlid fish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F02A-W(20)]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: 6 year old;Assisted Reproductive Technology;Blood Pressure;cardiometabolic risk;Child;Clinic;Clinic Visits;cohort;Epigenetic Process;follow-up;health difference;Home;In Vitro;Infant Development;Infertility;infertility treatment;Lipids;Measurement;Measures;New York;Obesity;Ovarian Hyperstimulation Syndrome;Ovulation;Ovulation Induction;Patient Recruitments;Process;recruit;repository;screening program;Services;Specimen;Subgroup;Testing;Time;training data;treatment effect;Twin Multiple Birth;Visit

PROJECT_TITLE: REPOSITORY SERVICES FOR UPSTATE KIDS FOLLOW UP SPECIMENS


NIH_SPENDING_CATS: Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PI_NAMEs: WHITE, KATHARINE  (contact)

PROJECT_TERMS: Boston;Clinical;Clinical Trials Network;Communication;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Contractor;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;Performance;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;Time;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - BOSTON


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Emphysema;Genetics;Human Genome;Lung;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PI_NAMEs: CRAPO, JAMES D (contact)

PROJECT_TERMS: Address;adjudication;Adverse event;Airway Disease;airway obstruction;Ancillary Study;Annual Reports;Archives;Area;Award;Bioinformatics;Biological Markers;Biological Specimen Banks;biomarker identification;Bronchodilator Agents;catalyst;Cause of Death;Certification;Cessation of life;Characteristics;chest computed tomography;chronic airflow obstruction;Chronic Obstructive Pulmonary Disease;Clinical;clinical center;Clinical Data;clinical research site;cohort;Collaborations;Collection;Communication;Communities;Compensation;Complex;Computer Security;Contractor;Contracts;Data;Data Coordinating Center;data format;data quality;data repository;Data Science;Data Security;Data Set;data sharing;data submission;database of Genotypes and Phenotypes;demographics;Diagnosis;Diffusion;digital;Disease Progression;disorder subtype;DNA Methylation;Documentation;Educational workshop;Electronics;Enrollment;Ensure;epidemiologic data;Epidemiology;Epigenetic Process;Event;frailty;Funding;Future;Genes;Genetic;genetic analysis;genetic association;Genetic Determinism;genome sequencing;Genomics;Goals;Grant;Image;image processing;imaging facilities;improved;Information Systems;insight;Institutional Review Boards;International;Internet;Journals;Laboratories;Link;longitudinal analysis;Longitudinal cohort;Longterm Follow-up;Machine Learning;Manuscripts;Measurement;Measures;Medical History;meetings;member;metabolomics;Metadata;Methods;Molecular;Monitor;mortality;Multiomic Data;Names;National Heart, Lung, and Blood Institute;new technology;Observational Study;Outcome;Oxygen;Participant;Pathway Analysis;Patients;Peer Review;Persons;Physical Performance;Physiological;Physiology;Policies;preservation;Procedures;programs;Proteomics;Protocols documentation;Publications;PubMed;Pulmonary Emphysema;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;quality assurance;Quality Control;Quality of life;Questionnaires;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resolution;Resources;Risk Factors;SARS-CoV-2 infection;Scanning;Schedule;Scientist;Smoker;socioeconomics;Specific qualifier value;Standardization;Subgroup;Support Contracts;Syndrome;System;Teleconferences;Telephone;Testing;Time;Tobacco use;Training;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Travel;United States National Institutes of Health;Update;Vaccination;Variant;Visit;Walking;web site;whole genome;Work;X-Ray Computed Tomography

PROJECT_TITLE: COPD(GENE): TASK B: "STEWARDSHIP OF BIOSPECIMEN AND DATA REPOSITORIES"


PI_NAMEs: SCHREIBER, COURTNEY  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - UPENN


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: STERLING

ORG_NAME: EXPERIMENTAL PATHOLOGY LABORATORIES

ORG_STATE: VA

PHR: This contract provides supports the activities of the Division of Translational Toxicology (DTT) hazard identification activities (i.e., evaluating the harmful effects of various chemicals or physical agents) targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents of public health concern.

PI_NAMEs: MILLER, RODNEY  (contact)

PROJECT_TERMS: Adverse effects;Apoptosis;Autopsy;Cell Proliferation;Cellular biology;Chemicals;Consult;Contracts;Data;Development;developmental toxicity;disorder prevention;DNA;DNA sequencing;Electron Microscopy;Ensure;Environmental Exposure;Evaluation;Exposure to;Genotype;Government;Hazard Identification;Histology;Immunohistochemistry;immunotoxicity;In Situ;In Situ Hybridization;Journals;Laboratories;Laboratory Animal Medicine;Malignant Neoplasms;Manuscripts;Molecular Biology;molecular pathology;Morphology;National Institute of Environmental Health Sciences;National Toxicology Program;Pathology;Peer Review;Preparation;Procedures;Process;Public Health;Publications;Reporting;reproductive toxicity;Research Design;Research Personnel;research study;RNA;Services;Slide;Specimen;Stains;Support Contracts;Techniques;Time;Tissues;Toxic effect;Toxicology;Training;working group

PROJECT_TITLE: Pathology Peer Review and Pathology Support for the DNTP and DIR at NIEHS (EPL)


ORG_CITY: WASHINGTON

ORG_NAME: ACADEMYHEALTH

ORG_STATE: DC

PI_NAMEs: KING, TAMIKA  (contact)

PROJECT_TERMS: health care delivery;Research;Scholars Program;visiting scholar

PROJECT_TITLE: HEALTHCARE DELIVERY RESEARCH VISITING SCHOLARS PROGRAM


PI_NAMEs: WESTHOFF, CAROLYN  (contact)

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - COLUMBIA


ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE Electronic cigarette (e-cig) use among adults remains the highest among those aged 18-24 years, despite critical knowledge gaps on chemical exposure, toxicity and potential health effects. New and emerging e-cig devices, such as disposable PODs, are of particular concern as it is currently unknown whether they emit toxic metals and aldehydes, and whether these devices have potential respiratory and inflammatory effects with use. By evaluating device characteristics and user vaping regimen in association with toxic metal and aldehyde exposure as well as respiratory outcomes and inflammation biomarkers, this study can generate critical data on chemical exposure and e-cig user health, which is urgently needed to inform FDA regulation of these newer devices.

PI_NAMEs: AHERRERA, ANGELA  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acrolein;Adult;Aerosols;Affect;aged;airway inflammation;Aldehydes;Behavior;Biological Markers;Blood;bronchial epithelium;Characteristics;Chemical Exposure;Chemicals;chemokine;cinnamic aldehyde;Clinical;cohort;Collecting Cell;Complement;Cross-Sectional Studies;cytokine;Data;design;Device Designs;Devices;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Environmental Epidemiology;Environmental Health;Epidemiologist;Epithelial Cells;Exhalation;Formulation;Free Radicals;Frequencies;Gene Expression;Gene Expression Profile;Goals;Health;Heating;High Pressure Liquid Chromatography;Immunologist;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Inflammation;Inflammatory;inflammatory marker;Inhalation;Inorganic Chemicals;Isoprostanes;Joints;JUUL;Knowledge;Lung;lung health;Malondialdehyde;Marketing;Measurement;Measures;Mediating;Mediation;Mediator;Mentors;Metal exposure;metal poisoning;Metallothionein;Metals;Methods;Nasal Epithelium;National Institute of Environmental Health Sciences;Nature;Nicotine;Nitric Oxide;non-smoker;Nose;novel;Organic Chemicals;Outcome;Oxidative Stress;Participant;Patient Recruitments;Phase;pollutant;Positioning Attribute;Prevalence;Proliferating;Proteins;Proxy;pulmonary function;Questionnaires;recruit;Regimen;Regulation;Research;Research Personnel;respiratory;respiratory health;Respiratory Signs and Symptoms;Sampling;Scientist;skills;Source;Spirometry;Stress;Symptoms;Tobacco;tobacco control;Toxic effect;toxic metal;Training;Urine;vaping;Work;young adult

PROJECT_TITLE: Respiratory Effects, Metal and Aldehyde exposure from e-cigarette use in young adults (REMA)

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: SUMMARY This project seeks to define the humoral correlates of immunity following infection as well as the durability of this protective humoral immunity both following natural infection or vaccination to inform vaccine development. Project Narrative

PI_NAMEs: BAROUCH, DAN H. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 2019-nCoV;Antibodies;Antibody Response;Antibody titer measurement;antigen binding;Antigens;aptamer;Automobile Driving;Award;Binding;biobank;Bioconductor;Biological;Biological Assay;Biophysics;booster vaccine;Boston;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;chemokine;Cities;Complement;Complement 1q;Computer Models;Computer software;Coupled;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Dendritic Cells;Development;Disease;Disease Outcome;Effector Cell;falls;Flow Cytometry;flu;Fluorescence;follow-up;Formulation;Fucose;Galactose;Genes;Helper-Inducer T-Lymphocyte;Hospitals;Human;Humoral Immunities;Immune response;Immunity;Immunologics;Individual;Infection;insight;interest;Kinetics;Knowledge;Lectin;Link;Macaca mulatta;Macrophage;Manufacturer;Massachusetts;Measures;Mediating;Memory;monocyte;Mucosal Immunity;N-terminal;Neutralizing antibody assay;neutrophil;nonhuman primate;Nucleocapsid;Outcome Measure;Output;pandemic preparedness;parallelization;Pathway interactions;Peripheral Blood Mononuclear Cell;Phagocytosis;Phenotype;Plasma;Population;post SARS-CoV-2 infection;Process;Proteins;Proteomics;Reading;receptor;receptor binding;Regimen;Research;response;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 immunity;SARS-CoV-2 variant;Sensitivity and Specificity;Serology;Serum;Sialic Acids;System;T cell response;T-Lymphocyte;Testing;Th1 Cells;Time;transcriptome sequencing;Universities;unsupervised clustering;uptake;Vaccinated;Vaccination;vaccine development;Vaccinee;Vaccines;variants of concern;Viral;volunteer

PROJECT_TITLE: Immunologic Signatures of SARS-CoV-2 Vaccination and Disease


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Hematopoietic stem cell's (HSC) symmetric and asymmetric divisions result in self-renewal and commitment to differentiation fates, a balance of which is critical for the persistence of HSCs to replenish the hematopoietic system. Built on recently identified role of RNA methylation in controlling HSC symmetric commitment, this proposal aims to define the molecular basis that RNA methylation relies on to control this division, as well as to elucidate novel regulators in HSC fate choices by implementing high-throughput approaches. Success of this work will define the novel regulators of HSC fate control and uncover novel therapeutic opportunities for hematological diseases and stem cell expansion.

PI_NAMEs: LUO, HANZHI  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Ablation;Achievement;Address;Affect;Automobile Driving;Bar Codes;Benchmarking;Blood;Blood Cells;Bone Marrow;cancer stem cell;career development;Catalytic Domain;Cell Fate Control;Cells;Cellular Assay;Clinic;cofactor;Complex;Data;daughter cell;Dedications;Defect;Dependence;Development;Development Plans;Disease;Engraftment;Environment;Equilibrium;Functional impairment;Genes;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;high throughput screening;Homeostasis;improved;In Vitro;induced pluripotent stem cell;innovation;insight;Knock-out;Knockout Mice;Knowledge;leukemic stem cell;Maps;Memorial Sloan-Kettering Cancer Center;Mentors;Messenger RNA;Methods;Methyltransferase;Modeling;Molecular;mouse model;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;Pancytopenia;Pathway interactions;Persons;Pharmacology;Phenotype;Population;Postdoctoral Fellow;programs;Property;Proteins;Publishing;Recovery;Reporting;Research;Research Proposals;RNA;RNA Editing;RNA methylation;RNA Splicing;RNA-Binding Proteins;Role;RUNX1 gene;self-renewal;single-cell RNA sequencing;Son;stem cell division;stem cell engraftment;stem cell expansion;stemness;Stress;success;System;Therapeutic;tool;Training;Transcript;transcriptome;Translating;Transplantation;Work

PROJECT_TITLE: Defining the molecular basis controlling hematopoietic stem cell symmetric and asymmetric divisions


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Overall: Narrative The application of high-content immune profiling tools has revolutionized our ability to decode disease etiology and processes. This Human Immune Project Consortium, Maternal ‘Omics to Maximize Immunity (MOMi), seeks to use a multi-OMICs approach to decode the unique nature of the immune system that evolves across gestation. The Projects will generate foundational data to guide rational design of customized vaccines that optimize both maternal and neonatal health.

PI_NAMEs: EDLOW, ANDREA GOLDBERG;ELOVITZ, MICHAL AVIVA;JUELG, BORIS DOMINIK;LAUFFENBURGER, DOUGLAS A (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 2019-nCoV;Allografting;Atlases;Autoimmune;Birth;cell type;Clinical;Communicable Diseases;Communities;COVID-19 pandemic;COVID-19 severity;Custom;Data;Data Analyses;data management;Data Set;density;Development;Disease;Ensure;Etiology;Fertility;Fertilization;fetal;Fetal health;Fetus;Genetic Transcription;Global Awareness;Growth;health of the mother;Human;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunologics;Immunology;implantation;improved;in vivo;Individual;Infection;Inflammation;Intervention;Invaded;Knowledge;Lactation;Maternal Health;maternal immune system;maternal vaccination;Maternal-fetal medicine;Maternally-Acquired Immunity;metabolomics;Metagenomics;Mothers;multidisciplinary;multiple omics;Nature;neonatal health;Newborn Infant;novel;novel therapeutics;novel vaccines;Organ;pathogen;Phase;Play;Population;predictive marker;Pregnancy;pregnancy health;pregnant;Pregnant Women;Process;prophylactic;Proteomics;Race;rational design;Recording of previous events;Research Personnel;Role;Secondary Immunization;Shapes;success;System;Systems Biology;targeted treatment;Technology;Time;Tissues;tool;Vaccination;vaccination strategy;vaccine immunogenicity;vaccine platform;vaccine trial;vaccine-induced immunity;Vaccines;vaccinology;Work

PROJECT_TITLE: Maternal Omics to Maximize Immunity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PHR: Project 2: Narrative  Project 2 seeks to utilize the unprecedented roll out of novel COVID vaccine platforms and routine vaccines  (influenza and pertussis) to define the impact of pregnancy on shaping vaccine-induced immunity, providing an  opportunity to chart the Pregnant Immune Atlas.

PI_NAMEs: JUELG, BORIS DOMINIK (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adenovirus Vector;Adjuvant;Affect;Allografting;Anti-Inflammatory Agents;Antibodies;Antibody titer measurement;antibody transfer;Antigens;Atlases;Awareness;B-Lymphocytes;Biochemical;Birth;booster vaccine;Case Fatality Rates;Cellular Assay;Cessation of life;Chronology;Clinical;Communicable Diseases;comorbidity;COVID-19 pandemic;COVID-19 vaccine;Data;Data Analyses;design;Disease;Eligibility Determination;Emergency Situation;experience;fetal;Fetal Growth;Fetus;Future;Genetic;Growth;Health Personnel;hemodynamics;Human Milk;Immune;immune function;immune reconstitution;Immune response;Immunity;Immunization;Immunize;immunogenic;Immunologics;Immunology;implantation;Infant;Infection;infection risk;Inflammation;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;Link;Maps;Maternal-fetal medicine;Messenger RNA;Morbidity - disease rate;mortality;Mothers;neonate;Newborn Infant;next generation;novel;novel vaccines;pandemic disease;Pertussis;Phase;phase III trial;Phenotype;Placenta;Placentation;Population;Predisposition;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Property;Proteins;Race;rational design;Recommendation;Recording of previous events;Research Project Grants;respiratory;response;RNA vaccine;Safety;Sampling;Serology;Shapes;Specialist;success;Syndrome;System;T cell response;T-Lymphocyte;Therapeutic;therapy design;tool;transcriptome;Vaccination;Vaccine Design;vaccine distribution;vaccine platform;vaccine response;vaccine safety;vaccine strategy;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Viral;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Research Project 2 The pregnancy AdaptOME


NIH_SPENDING_CATS: Aging;Clinical Research;Comparative Effectiveness Research;Disability Research;Lung;Nutrition;Obesity;Organ Transplantation;Patient Safety;Prevention;Sarcopenia;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This proposal is focused on advancing body composition quantification of lung transplant candidates by bioelectrical impedance assay; determining the responsiveness of patient-reported survey instruments to lung transplant perioperative complications; and developing prediction models to identify which transplant recipients are at risk for poor quality of life and graft failure. This focus directly addresses areas identified by the National Heart Lung and Blood Institute as key priorities to advancing lung transplant clinical care and research.

PI_NAMEs: SINGER, JONATHAN PAUL (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Accounting;Address;Adoption;Anxiety;Area;Biolectric Impedance;Biological Assay;Body Composition;Body mass index;Body measure procedure;Cessation of life;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;cost;Data;Development;disability;Dual-Energy X-Ray Absorptiometry;Enrollment;Evaluation;Event;experience;frailty;Future;graft dysfunction;graft failure;graft function;Habilitation;Health;health related quality of life;Hospitalization;improved;Individual;innovation;Intervention;Intervention Studies;Intuition;Investigation;Knowledge;Length of Stay;Lung Transplantation;Mental Depression;Methods;Modality;Modeling;mortality;Multicenter Studies;Multicenter Trials;National Heart, Lung, and Blood Institute;novel;nutrition;Obesity;Observational Study;Outcome;Outcome Measure;Patient Outcomes Assessments;patient response;Patient Selection;Patient-Focused Outcomes;Patients;Perioperative;Perioperative complication;Phenotype;physical conditioning;Physical Function;post-transplant;Postoperative Period;predictive modeling;Productivity;prognostic;pulmonary function;Quality of life;Reporting;response;Risk;Risk Factors;sarcopenia;sarcopenic obesity;Scanning;Surveys;Survivors;Technology;Time;transplant centers;Transplant Recipients;Transplantation;Waiting Lists;Work

PROJECT_TITLE: The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.


ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative (Overall)  The kidney is a vital organ that maintains minute-to-minute regulation of blood composition, a process that occurs through a complex organization of cells and structures into functioning units. The goal of this project is to create a comprehensive spatial map of the various types of molecules using state of the art technologies that will provide a readable and integrated output spanning regulation of genes, gene expression, proteins, metabolites, lipid and extracellular mass at a single cell resolution. Through studying kidney tissue from a representative diverse population, this work will provide key understanding of the functions of the kidney and the changes that occur with aging and disease.

PI_NAMEs: ASHKAR, TAREK MAURICE;JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;absorption;Acids;Acute;Adult;Affect;Age;Aging;Anatomy;ATAC-seq;Atlases;base;biobank;Biodiversity;Biological Assay;biological heterogeneity;Biology;Biomedical Engineering;Biopsy;Blood;blood filtration;blood pressure regulation;career;Cell Nucleus;cell type;Cells;Cellular biology;Chromatin;Chronic;Clinical;cohort;Collaborations;Communities;Complex;Data;Data Analyses;data integration;data pipeline;Data Set;design;Dimensions;disadvantaged student;Disease;Disease Outcome;Drug Targeting;Educational Activities;Electrolyte Balance;empowerment;End stage renal failure;environmental enrichment for laboratory animals;Epigenetic Process;epigenome;Equilibrium;Erythropoiesis;Ethnic Origin;extracellular;Extracellular Matrix Proteins;Fluorescence Microscopy;Fostering;gain of function;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genome-wide;Goals;Health;Human;Human BioMolecular Atlas Program;Image;Immune;Immunofluorescence Immunologic;innovation;insight;Institution;Internships;Kidney;Kidney Diseases;Knowledge;Label;Life;Light;Link;Lipids;Maps;men;Metadata;Microscopic;Microscopy;Molecular;Molecular Biology;Molecular Structure;multimodal data;multimodality;multiple omics;Nebraska;Neighborhoods;Nephrons;Nerve;neurovascular;Organ;Output;Oxidation-Reduction;Pathology;Pathway interactions;Patients;Persons;Phase;Physicians;Physiology;Population Heterogeneity;precision medicine;Process;Productivity;Proteins;Race;Raman Spectrum Analysis;Readability;Regulation;Renal function;Research Personnel;Resolution;Resources;RNA;Sampling;Scientist;sex;single cell technology;Small Nuclear RNA;Sodium Chloride;solute;Source;Structure;Students;Technology;Textbooks;Tissues;tool;Transcript;transcriptome;transcriptomics;Underrepresented Students;Vision;Water;water conservation;Woman;Work

PROJECT_TITLE: Kidney single cell and spatial molecular atlas project - KIDSSMAP


PI_NAMEs: JAIN, SANJAY  (contact)

PROJECT_TERMS: 3-Dimensional;absorption;Adult;Anatomy;ATAC-seq;Atlases;Biological Assay;Biopsy;blood pressure regulation;Blood Vessels;Cell Nucleus;cell type;Cells;Chromatin;Clinical;Communities;Complex;Data;Data Analyses;Data Set;Detection;Dimensions;Disease;Drug or chemical Tissue Distribution;Emerging Technologies;Ethics;Extracellular Matrix;Feedback;Filtration;Fluorescence Microscopy;Gene Expression;Genetic Transcription;genome-wide;genomic data;Goals;Heterogeneity;Homeostasis;Human;Human BioMolecular Atlas Program;Immune;Immunofluorescence Immunologic;Immunologic Surveillance;improved;In Situ;Infrastructure;interest;interoperability;Kidney;Label;Life Cycle Stages;life span;Light;Link;Lipids;Lobe;Lobule;Maps;Methods;Microscopy;Modality;Molecular;multimodality;Neighborhoods;Nephrons;Nerve;neurovascular;new technology;Organ;Output;Patients;Phase;Physiological;preservation;Process;Proteins;Protocols documentation;Quality Control;Race;Raman Spectrum Analysis;Resolution;Resources;RNA;Role;Sampling;sex;single nucleus RNA-sequencing;Site;Small Nuclear RNA;solute;Source;Specimen;Technology;tissue processing;Tissues;tool;Transcript;transcriptomics;usability;Water;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PI_NAMEs: BROWN, JUSTIN C (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adipose tissue;Affect;Algorithmic Analysis;Animals;Anorexia;anorexic;anti-cancer treatment;Atlases;Atrophic;Autophagocytosis;Basic Science;Behavior;behavioral study;Biological Markers;Blood;Body Composition;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;cancer therapy;carcinogenesis;Catabolic Process;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical biomarkers;clinical care;clinical phenotype;Clinical Research;clinical subtypes;Clinical Trials;clinically relevant;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;cytokine;Cytometry;Data;Desire for food;Diagnosis;dietary;Eating;effective therapy;Endocrine;Energy Metabolism;Epidemiology;Etiology;Fatty acid glycerol esters;Feeding behaviors;Foundations;Future;GDF15 gene;Gene Expression Profiling;Generations;Genes;Genetic;Geography;Goals;gut microbiome;high risk;Histologic;Hormonal;Hormones;host neoplasm interaction;Human;Image;imaging Segmentation;Immune;Immunology;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;innovation;insulin signaling;Interleukin-6;International;Intervention;Intrinsic factor;Investigation;Isotopes;Lead;Life Expectancy;Link;Lipolysis;lung microbiome;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;microbial;microbiome;microbiota;molecular subtypes;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mus;Muscle;neoplastic cell;Neuroendocrinology;Neurologic;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;novel;nuclear imaging;Nutrient;Observational Study;optogenetics;Organ;Organoids;Pathway interactions;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Performance Status;Peripheral;pharmacologic;Phenotype;Physical Function;Physiological;Pre-Clinical Model;Prospective, cohort study;Quality of life;Recovery;recruit;response;Risk;Science;Scientist;Skeletal Muscle;Specialist;System;Therapeutic;Time;Tissues;tool;Toxin;Translations;treatment response;treatment strategy;treatment trial;tumor;tumor metabolism;tumor microenvironment;Ubiquitin;uptake;Validation;virtual;Vision;wasting;Wasting Syndrome;Whole Organism;Work;Xenograft procedure

PROJECT_TITLE: CANCAN - PENNINGTON


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Visual perception and visually-guided decision-making rely on the flow of information between many cortical areas and subcortical brain structures. This proposal combines state of the art neurophysiological approaches and causal circuit manipulation methods to elucidate the complex interactions between visual processing and executive function neural circuits. We expect our findings will contribute considerably to our understanding of the neural computations that underlie sensory processing and cognition in health and disease.

PI_NAMEs: ANDREI, ARIANA R (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;American;Anatomy;Animals;Area;area striata;Attention;Attention deficit hyperactivity disorder;Automobile Driving;awake;Behavior;Behavioral;Blood - brain barrier anatomy;Brain;Cell Nucleus;cell type;Cells;Cognition;Cognitive;Communication;Complex;Decision Making;Detection;Development;Devices;Diffuse;Disease;Distal;Electrophysiology (science);Engineering;executive function;experience;Focused Ultrasound;Genes;Goals;Health;Homologous Gene;Human;improved;in vivo;Individual;Knowledge;Lateral;Learning;Lesion;Macaca;Measures;Medial;Methodology;Methods;Monkeys;Neocortex;Nervous System Disorder;neural;neural circuit;Neurons;neurophysiology;neuroprosthesis;nonhuman primate;novel;novel strategies;Opsin;optogenetics;Organ;Perception;Performance;Phase;Population;Prefrontal Cortex;Primates;programs;Psychophysics;Pulvinar structure;Reporting;Research;response;Rodent;Role;Schizophrenia;Sensory;sensory input;Signal Transduction;Stimulus;Structure;Techniques;Technology;Testing;Thalamic Nuclei;Thalamic structure;Training;Transfection;Viral;Virus;Vision;Visual;Visual attention;visual information;Visual Perception;visual processing;Work

PROJECT_TITLE: Role of cortical connections to higher-order thalamic nuclei in visual decision-making


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_NAME: AXIOFORCE INC

PHR: PROJECT NARRATIVE  Aging individuals who develop abnormal gait patterns have a greater than two-fold increased risk of institutionalization and death, but early detection of gait disorders remains challenging due to the lack of technology capable of true at-home gait monitoring. Unlike existing gait analysis methods available in laboratory settings, Axioforce's Axiostride is a wearable technology that automatically collects and monitors high fidelity gait data during at-home real life activities minimizing burden on patient and healthcare provider. This remote system empowers healthcare providers to target early detection of declining gait function for individuals >60 years-old, preventing loss of independence and delaying mortality.

PI_NAMEs: MILLER, JONATHAN DANIEL (contact)

PROGRAM_OFFICER_NAME: GUTOWSKI, STACIE MARIE

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Adoption;Adult;age related;aged;Aging;aging population;Algorithms;Alzheimer's disease diagnosis;American;Area;Artificial Intelligence;artificial intelligence algorithm;Automation;battery life;Cessation of life;Classification;classification algorithm;clinical care;cloud platform;commercial application;Communication;Communities;Computer software;cost;Custom;Dangerousness;Data;Data Analyses;Data Collection;data handling;data quality;design;Detection;Development;Devices;digital treatment;Early Diagnosis;Early Intervention;Elements;empowerment;Equipment;Event;falls;field study;foot;functional decline;functional loss;Gait;Gait abnormality;gait examination;Generations;Goals;Grant;health empowerment;Health Personnel;Home;Hour;human old age (65+);Human Resources;improved;Individual;insight;Institutionalization;Knowledge;Laboratories;Life;Marketing;Measures;Medical Care Costs;Medical Device;Methods;Mobility decline;Modeling;Monitor;mortality;Motion;next generation;Nursing Homes;Pathologic;Pathology;Patients;Pattern;Performance;Phase;Physical Performance;Pilot Projects;Population;portability;power consumption;prevent;Process;Protocols documentation;prototype;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;Research Personnel;Risk;Running;Sampling;screening;sensor;Shoes;software systems;Stroke;System;technological innovation;Technology;Testing;Time;tool;Training;wearable device;wearable monitor;Work

PROJECT_TITLE: 3D force sensing insoles for wearable, AI empowered, high-fidelity gait monitoring


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Pediatric;Prevention;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Congenital obstructive uropathy is the most frequent anomaly of the urinary tract detected by prenatal ultrasound, occurring in up to 2% of normal pregnancies. Here we propose to study the human genetics of congenital obstructive uropathy and its subphenotypes using large-scale genetic screenings for rare and common variant in uniquely large and deeply phenotyped cohorts. This study will provide insight into the etiology of congenital obstructive uropathy and will help improve diagnosis, prognostication, family planning, and, ultimately, therapy for this condition.

PI_NAMEs: SANNA-CHERCHI, SIMONE  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Birth;Caring;Categories;Clinical Research;cohort;congenital anomalies of the kidney;congenital anomaly;Copy Number Polymorphism;Counseling;CRKL gene;Data;design;Detection;Development;Diagnosis;Dialysis procedure;Disease;DLG1 gene;End stage renal failure;Etiology;Family;Family Planning;fetal;Foundations;Genes;Genetic;genetic architecture;Genetic Models;Genetic Screening;Genetic study;genetic testing;genetic variant;Genets;genome wide association study;genome-wide;Goals;Grant;Human;Human Genetics;Image;imaging study;improved;insight;Joints;Kidney;Kidney Failure;Left;Life;malformation;Medical;Morbidity - disease rate;mortality;mouse model;Mutate;National Institute of Diabetes and Digestive and Kidney Diseases;novel;NRIP1 gene;Obstruction;Operative Surgical Procedures;Outcome;Patients;Phenotype;Population Control;Positioning Attribute;postnatal;Pregnancy;prenatal;Prenatal care;Preparation;Prognosis;prognostication;programs;progression risk;research clinical testing;Risk;Risk Reduction;risk stratification;Role;Severities;Statutes and Laws;Surgical Management;Technology;Termination of pregnancy;Transplantation;ultrasound;urinary;Urinary tract;urinary tract obstruction;Variant;Vertebrates

PROJECT_TITLE: Human genetic studies to solve the etiology of congenital obstructive uropathy and its subphenotypes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Kidney stones are a painful and highly recurrent disease affecting approximately 1 in 10 people. Pet dogs also naturally form stones, and our preliminary work found defects in a major urinary protein that cause stones in dogs. The proposed research will investigate the mechanism by which these protein defects causes stone formation and will direct future development of tools to diagnose and prevent kidney stones in people.

PI_NAMEs: FURROW, EVA  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Affect;Calcium;Calcium Oxalate;canine model;Canis familiaris;cytokine;Data;Defect;Diagnosis;Diet;Disease;Distal;Environment;Excretory function;experience;extracellular vesicles;Future;General Population;Genes;genetic variant;Genomics;Health;Health Care Costs;Human;human model;human old age (65+);Hydrophobicity;hypercalciuria;immunoregulation;Inflammatory;insight;Kidney;Kidney Calculi;Kidney Diseases;Link;major urinary proteins;Metabolic;microbiome;Modeling;Molecular;Nephrons;novel strategies;Pain;Pathogenesis;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;pleiotropism;polymerization;Polymers;Population;prevent;Preventive therapy;Property;Protein Secretion;Proteins;Proteome;Recurrence;Recurrent disease;renal calcium;Research;Risk;Risk Factors;risk mitigation;risk variant;Rodent;Role;solute;Testing;therapy development;tool development;UMOD gene;United States;urinary;Urine;Variant;Work

PROJECT_TITLE: Leveraging a unique dog model to determine the role of uromodulin in kidney stone disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Technology to study nonmalignant hematology is rapidly evolving. To enhance the Cell Preparation and Analysis Core, we propose to add cutting edge methodology in CYTOF and single cell cytokine release assessment and analyses. To enhance the Animal Modeling Core, we propose to add a repository of bone marrow and blood samples from patients with nonmalignant hematological diseases. To enhance the Imaging Core, we propose to add assistance and training in FLASH-PAINT for assessing unlimited numbers of antigens on a single cell using immunofluorescence. By continuing to provide training in cutting edge technologies largely, and recently developed at Yale, to the broad non-Yale biomedical community, we aim to foster paradigm shifting breakthroughs in nonmalignant hematology.

PI_NAMEs: HWA, JOHN ;KRAUSE, DIANE S (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Administrative Supplement;Animal Model;Animals;Antigens;Aplastic Anemia;Area;Award;Bioinformatics;Biological;Biotechnology;Blood;Blood Cells;Blood Platelets;Blood specimen;Bone Marrow;cell preparation;cell repository;Cells;Cellular Morphology;Classification;Clinical;college;Communities;Complement;cytokine;Data;Diabetes Mellitus;disadvantaged background;Disease;Dysmyelopoietic Syndromes;Education;Emerging Technologies;Evaluation;experience;Faculty;Fee-for-Service Plans;Flow Cytometry;Fostering;frontier;Grant;Health;Hematological Disease;Hematology;Hematopoiesis;High School Student;Human;humanized mouse;Image;Image Enhancement;Imaging technology;Immunofluorescence Immunologic;improved;innovation;insight;Institution;International;Investigation;Journals;Liver diseases;Maps;medical schools;Methodology;Microscopy;Mission;Morbidity - disease rate;mortality;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;next generation;Non-Malignant;Organelles;Paper;patient population;Patients;Peer Review;Performance;platelet phenotype;Play;Postdoctoral Fellow;Process;Publications;Publishing;repository;Research;Research Personnel;Resources;Role;Sampling;Series;Services;Sickle Cell Anemia;stem cell biology;stem cells;Structure;success;synergism;Techniques;Technology;Training;undergraduate student;Underrepresented Minority;Xenograft procedure

PROJECT_TITLE: Yale Cooperative Center of Excellence in Hematology


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Glioblastoma is a universally lethal cancer that is currently refractory to immunotherapies that have proven to be breakthrough treatments for other cancers. This research proposal will deeply characterize the immunosuppressive myeloid cells in these tumors to better understand the mechanism by which they suppress the immune system and lead to ineffective immunotherapies. These studies will provide data needed to help design rational strategies that increase the effectiveness of immunotherapies for brain tumor patients.

PI_NAMEs: MILLER, TYLER EUGENE (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Academia;Address;Advisory Committees;Biological Models;Biology;Biotechnology;Brain;Brain Neoplasms;Bromodomain;Cancer Patient;cancer type;CAR T cell therapy;career development;cDNA Library;cell transformation;Cells;Clinical;Communication;Cues;Cytotoxic T-Lymphocytes;Data;design;Development Plans;Effectiveness;Effector Cell;EP300 gene;Epigenetic Process;experience;experimental study;Faculty;Gene Silencing;General Hospitals;genomic data;Glioblastoma;Grant;Immune;Immune checkpoint inhibitor;Immune system;Immunology;Immunology procedure;Immunosuppression;Immunotherapy;inhibitor;Invaded;Laboratories;Leadership;Life;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Massachusetts;Mentors;Mentorship;Methods;Microglia;migration;Mitochondria;Modeling;monocyte;mutant;Mutation Detection;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Organoids;Pathology;Patients;Peripheral;peripheral blood;Phenotype;Physicians;Positioning Attribute;prevent;Primary Neoplasm;Professional Competence;Program Development;programs;rational design;Recording of previous events;Recurrence;Refractory;Research;Research Proposals;Running;Sampling;Scientist;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;skills;small molecule;small molecule inhibitor;Structure;System;T cell infiltration;targeted treatment;Technical Expertise;Techniques;Therapeutic;therapeutic target;therapy design;tool;Training;transcription factor;transcriptome;tumor;tumor microenvironment;Work;Writing

PROJECT_TITLE: Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Sepsis is a common and often deadly condition of organ dysfunction due to infection that is responsible for 1.7 million hospitalizations and an estimated 260,000 deaths annually in the United States; survivors of sepsis are often left debilitated due to muscle atrophy, which hinders independence and reduces quality of life. Unfortunately, other than physical rehabilitation, there are no treatments currently available for post-sepsis muscle atrophy because we do not understand how sepsis causes muscle atrophy. This project will study how the gut microbiome, the bacteria that live in the human intestinal tract, contributes to muscle atrophy during sepsis, with a goal of identifying new targets for treatment.

PI_NAMEs: BONGERS, KALE S (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;Anabolism;Animal Model;Antibiotic Therapy;Antibiotics;Atrophic;Award;Bacteria;Biology;Blood;Calibration;career development;Cessation of life;Complement;Critical Care;Critical Illness;Data;Debility;Development;Development Plans;Doctor of Medicine;Doctor of Pharmacy;Doctor of Philosophy;Early Intervention;Ecology;endurance exercise;exercise capacity;experience;experimental study;Financial cost;Five-Year Plans;Foundations;Functional disorder;Future;Gene Expression;Germ-Free;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Hospitalization;Human;Hypertrophy;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Intestines;Investigation;Kale - dietary;Left;Lower Gastrointestinal Tract;Lung;Measures;Mediating;Mediator;Medical;Medicine;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Metagenomics;Michigan;microbial;microbiome;microbiome research;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Fibers;muscle form;muscle metabolism;muscle physiology;Muscle Weakness;Muscular Atrophy;Obesity;Organ;Outcome;Output;Pathogenesis;Patients;Pharmacotherapy;Physical Rehabilitation;Physicians;Play;post-doctoral training;prevent;Productivity;Publishing;Quality of life;Regulation;Research;Research Personnel;response;Risk;Role;Scientist;Secondary to;Sepsis;Severities;Skeletal Muscle;skeletal muscle wasting;skill acquisition;skills;success;Supplementation;Survivors;Swab;Techniques;Testing;Therapeutic;Tissues;Training;Translating;United States;Universities;Variant;Volatile Fatty Acids;Work

PROJECT_TITLE: The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

PHR: PROJECT NARRATIVE Alcoholic hepatitis is a devastating disease with poor clinical outcomes. In this study we will evaluate phenotypic and functional differences in neutrophils and their interactions with other liver cell types in alcoholic hepatitis. Our study will also evaluate the role of neutrophil extracellular traps in alcohol-associated liver disease and the mechanistic role of Bruton tyrosine kinase, a signaling molecule that we newly discovered as highly activated in alcoholic hepatitis. We will assess whether targeting BTK or neutrophils could be a feasible therapeutic target for amelioration of alcohol-associated hepatitis.

PI_NAMEs: SZABO, GYONGYI  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acute;Agammaglobulinaemia tyrosine kinase;Alcoholic Hepatitis;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;cell type;Cells;Chronic;Clinical;Complex;density;Disease;exhaust;experimental study;extracellular;Family;Fibrosis;Functional disorder;Generations;Hepatic Stellate Cell;Hepatitis;Hepatocyte;Heterogeneity;Immune signaling;in vivo;Inflammasome;Inflammation;insight;IRF3 gene;Liver;liver injury;Macrophage;Mediating;member;Molecular;monocyte;mouse model;Mus;Myelogenous;neutrophil;Neutrophil Activation;new therapeutic target;novel;Outcome;Pathway interactions;Patients;Phenotype;Phosphorylation;Play;Population;Population Density;Pre-Clinical Model;Production;Protein Tyrosine Kinase;Reporting;Role;Signal Transduction Pathway;Signaling Molecule;single-cell RNA sequencing;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;therapeutic target

PROJECT_TITLE: Innate immune signaling in alcoholic liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: PROJECT NARRATIVE How the two major cell types (epithelial and mesenchymal cells) interact with each other to form different organs in our body is a major question is biology. Answering this question is essential for understanding where different organs come from and provides a crucial step towards engineering tissues for regenerative medicine. This project will develop novel reconstitution-based approaches to systematically reconstruct the “communication codes” between epithelial and mesenchymal cells, and to understand how distinct communication codes lead to diverse cell types and tissue shapes among different organs.

PI_NAMEs: LI, PULIN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Adult;Biology;cell type;Cells;Code;Communication;Computer Models;Development;Disease;Embryo;Engineering;Epithelial Cells;Epithelium;Extracellular Matrix;Gene Expression Profile;genetic manipulation;Goals;Inflammation;injury and repair;insight;interest;Lead;Measurement;Mesenchymal;model development;Morphogenesis;novel;Organ;organ growth;Organogenesis;Organoids;Physiology;Play;reconstitution;reconstruction;Recording of previous events;Regenerative Medicine;Role;Shapes;Signal Transduction;Specificity;Structure;System;Testing;Tissue Engineering;Tissues;tool;tumor progression

PROJECT_TITLE: Systematic Reconstruction of Epithelial-Mesenchymal Communication in Organ Development


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_DEPT: GENETICS

PHR: Project Narrative: Epigenetic regulators have limited target specificity and yet are essential for mammalian embryogenesis, complicating efforts to discriminate context-specific functions that may cause phenotypic abnormalities. Here I propose a foundational new strategy to generate and comprehensively analyze complex mutant embryos across multiple scales, allowing me to directly connect breakdowns in chromatin regulation or the maternal environment to key molecular drivers of reproductive and fetal pathologies. In addition to substantially advancing these critical human health concerns, I will also optimize a series of new technologies specifically designed to recover previously opaque dimensions of development, including the emergence of phenotypic variation that is typical of many congenital disorders.

PI_NAMEs: SMITH, ZACHARY DYLAN (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Accounting;Address;Affect;Cell Line;cell type;Cells;Chromatin;chromatin remodeling;Code;cohort;Complex;Congenital Abnormality;Congenital Disorders;Data;design;Development;Developmental Process;Diagnostic;dietary;Dimensions;DNA;Embryo;Embryonic Development;Environment;Environmental Impact;Enzymes;Epigenetic Process;epigenetic regulation;fetal;Fetal Diseases;flexibility;Folic Acid;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Markers;Genome;Health;Human;indexing;innovation;Intervention;Methods;Micromanipulation;Modeling;Molecular;Morphology;mutant;Nature;new technology;novel;Organism;Organogenesis;Pathology;Pathway interactions;Penetrance;Phenotype;Polycomb;Post-Translational Protein Processing;Pregnancy;Process;programs;Regulation;Repression;Reproducibility;reproductive;Reproductive Medicine;Resolution;Series;single cell analysis;Specific qualifier value;Specificity;System;Techniques;Tissues;Titrations;tool;transcription factor;Validation;Variant

PROJECT_TITLE: Epigenetic and environmental impact on early embryonic development


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Kidney Disease;Patient Safety

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) incidence in the US is estimated to be about 6.8/1000 population and contributes to the development or progression of chronic kidney disease, end-stage renal disease, cardiovascular symptoms, and death, not to mention recurrent AKI episodes and impaired health-related quality of life. Processes of care after AKI hospitalization have been found to be suboptimal, with lack of continuity of care, delayed follow-up and suboptimal medication management exacerbating the risks of adverse outcomes. Results from the COPE- AKI Consortium will lead to interventions to optimize processes of care and identify key pharmacologic and non-pharmacologic interventions to reduce morbidity among these high-risk patients.

PI_NAMEs: ABEBE, KALEAB Z (contact);FRIED, LINDA FAITH;KANE-GILL, SANDRA L;PALEVSKY, PAUL M

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;adverse outcome;Ambulatory Care;Biometry;Cardiovascular system;Caring;Cessation of life;Chronic Kidney Failure;Clinical;clinical center;Clinical Data;Clinical Trials;Clinical Trials Design;Collaborations;Continuity of Patient Care;Data;Data Analyses;Data Collection;data management;design;Development;End stage renal failure;experience;follow-up;Glucose;Goals;health related quality of life;high risk;Hospitalization;Impaired health;Incidence;Intervention;Kidney Diseases;Knowledge;Measurement;Medication Management;Morbidity - disease rate;multidisciplinary;Nonpharmacologic Therapy;Online Systems;Outcomes and Health Services Research;patient engagement;Patient Outcomes Assessments;Patients;pharmacologic;Phase;Population;Process;process optimization;programs;protocol development;Recording of previous events;Recurrence;Renin-Angiotensin-Aldosterone System;Research;Risk;Risk Factors;Sodium;symporter;Symptoms;Syndrome;System;telehealth;Testing;Universities

PROJECT_TITLE: The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)-Supplement


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MALIN, BRADLEY A. (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;adverse outcome;Algorithms;Area;Artificial Intelligence;Behavioral Research;Benefits and Risks;Big Data;Bioethics;Biomedical Research;Bridge to Artificial Intelligence;Catalogs;Climacteric;Clinical;clinical decision-making;Collaborations;Collection;Communities;community engagement;Consent;Core Assembly;Data;Data Collection;data management;Data Protection;Data Set;decision making algorithm;Development;digital health;digital tool;distrust;Economics;Ensure;Environment;Equity;Ethical Issues;Ethics;European;experience;Foundations;Future;Generations;Guidelines;health care delivery;Healthcare;Human;human centered design;implementation science;improved;Individual;Informatics;Infrastructure;interdisciplinary approach;Knowledge;Laws;Learning;learning community;legal implication;Literature;Machine Learning;Medicine;multidisciplinary;Needs Assessment;outreach;Persons;prevent;Privacy;privacy protection;Process;programs;Public Policy;Public Relations;racial bias;Regulation;Research;Research Ethics;response;responsible artificial intelligence;Rights;Running;scaffold;social;Societies;success;Surveys;Sustainable Development;symposium;Technology;technology development;Time;tool;Trust;trustworthiness;Unconscious State;usability;Vision;willingness;Work;World Health Organization

PROJECT_TITLE: Ethics Core (FABRIC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1]


ORG_CITY: GALVESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE Soluble urokinase activating receptor (suPAR) has been implicated as one of the significant risk and pathogenic factors for the onset and progression of chronic kidney diseases regardless of the etiologies. In this grant application, we focus on the role of the proteolytic fragment of suPAR, D2D3, in simultaneously injuring two organs, the kidney and the pancreas. The ability to study molecular mechanisms of injury to two organs and organ-specific cell types (glomerular podocytes and β-cells of the pancreas), is a critical step in developing novel, mechanism-specific therapeutics for both, chronic kidney diseases and insulin-dependent diabetes mellitus.

PI_NAMEs: ALTINTAS, MEHMET M;SEVER, SANJA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TITLE: Role of proteolytic suPAR fragment in insulin dependent diabetes and kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative HeartShare seeks to enroll persons with heart failure with preserved ejection fraction (HFpEF), a complex and poorly understood disease, as well as control participants, into an observational study designed to clarify the causes of HFpEF. Non White persons are more likely to have HFpEF but have been underrepresented in prior research and in HeartShare itself thus far; after 1/4th of recruitment is completed, less than 20% are non-White (goal is 40% non White enrollment). Thus we propose appointing a Diversity Champion to work closely with the HeartShare study leaders to accomplish the following: comprehensively assess resources and strategies for enrolling minority participants at each of the 7 clinical sites, use the results of the assessment to develop optimal practices for diversifying enrollment tailored to each site’s population, share these practices with HeartShare sites, and to continuously monitor progress and dynamically adjust strategies as needed to help ensure optimal participant diversity and inclusion across HeartShare.

PI_NAMEs: KITZMAN, DALANE W (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Address;Affect;African American;Aging;arm;Biological;Black American;Black Populations;Black race;career;Child Care;clinical center;Clinical Investigator;Clinical Research;clinical research site;cohort;Collaborations;community engagement;community partners;comorbidity;Complex;Consensus;Data;Disease;Disproportionately impacts women;distrust;diversity and inclusion;EFRAC;Enrollment;Ensure;ethnic minority population;Evidence based treatment;experience;Female;Focus Groups;Functional disorder;Funding;Future;Goals;Group Meetings;Health;health equity;health equity promotion;Heart;Heart Atrium;Heart failure;Hispanic;improved;Individual;informant;Institution;Intervention;Interview;Leadership;Measures;meetings;Minority Enrollment;Minority Groups;minority patient;Minority Women;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;novel;Observational Study;Outcome;Participant;participant enrollment;Patient Recruitments;Patient Selection;Patients;Persons;Phenotype;Population;preservation;Prevalence;primary outcome;programs;racial minority population;recruit;Registries;Research;Research Design;Research Personnel;Resources;Signal Transduction;Site;social;STEM research;Surveys;Syndrome;Testing;Therapeutic Intervention;Time;Translations;Transportation;trend;Underrepresented Minority;Underrepresented Populations;Update;Variant;virtual;Work

PROJECT_TITLE: Wake Forest Atrium HeartShare Clinical Center


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: PARMAN, TOUFAN  (contact)

PROJECT_TERMS: ADME Study;Animals;Biological Assay;Biological Testing;chemical synthesis;Clinical;clinical lot;Clinical Trials;Contraceptive Agents;Contraceptive Devices;Contraceptive methods;design;Development;drug development;Drug Formulations;Endocrine;Evaluation;Formulation;Good Manufacturing Process;In Vitro;in vitro Assay;in vivo;Investigational Drugs;Investigational New Drug Application;lot production;manufacture;men;Methods;Microsomes;Mission;National Institute of Child Health and Human Development;new chemical entity;novel therapeutics;Ovulation;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Plasma;Play;pre-clinical;preclinical development;Process;product development;Production;programs;Research;research clinical testing;Research Personnel;Research Support;Role;Route;Safety;sperm cell;sperm function;System;Testing;Toxic effect;Toxicology;Woman

PROJECT_TITLE: BIOLOGICAL TESTING FACILITY - "PRECLINICAL DEVELOPMENT OF CONTRACEPTIVES"


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: PEKOSZ, ANDREW  (contact)

PROJECT_TERMS: Animals;Cohort Studies;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;response;Sampling;transmission process;Vaccination;vaccine development

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animals;Basic Science;Cohort Studies;Coronavirus;COVID-19;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Infection;Molecular;Pathogenicity;Research Activity;respiratory virus;response;Sampling;transmission process;Vaccination;Virus

PROJECT_TITLE: CEIRR: COVID-19 Research Activities


PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;response;Sampling;transmission process;Vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;Research Activity;response;Sampling;transmission process;universal influenza vaccine;Vaccination;vaccine development;Vaccine Research

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: The goal of the Evidence to Policy Evaluation Center for Veterans (EPEC-Vet) is to improve Veteran care and outcomes by conducting rigorous independent evaluations to inform VA policies and programs. These evaluations will address effectiveness, efficiency and sustainability in accordance with the Evidence Act of 2018 (US Public Law 115-435). We will build an infrastructure to support rigorous and timely evaluations by 1. establishing a robust evaluation program to support the planning and conduct of two evaluations per year, 2. Incorporate innovative methods, data collection and/or analytic strategies including developing a set of innovative common evaluation metrics, and 3. employing state-of-the-art knowledge translation methods and use of common evaluation metrics to effectively disseminate results to key VA stakeholders and broader policy and scientific communities.

PI_NAMEs: STROUPE, KEVIN T.;WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Achievement;Address;Affect;Agreement;Area;Budgets;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic Care;Collaborations;Communication;Communities;Community Healthcare;Complement;Complex;connected care;Contracts;Data;Data Analytics;Data Collection;Databases;design;design and construction;Development;Diffusion;Disease;Dissemination and Implementation;dissemination strategy;economic impact;Effectiveness;Elements;Ensure;Evaluation;evidence base;experience;Feedback;flexibility;Foundations;Generations;Goals;Government Agencies;Health Services;Healthcare;Homelessness;implementation facilitation;implementation framework;implementation strategy;improved;Infrastructure;innovation;knowledge translation;Laws;Leadership;Measures;Methodology;Methods;Modeling;Nursing Services;Office Nursing;operation;Outcome;Patient-Centered Care;pharmacy benefit;Policies;Policy Analysis;Policy Making;pragmatic trial;Principal Investigator;Process;Program Evaluation;programs;prospective;Qualifying;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Seasons;Site;skills;Spinal cord injury;statistics;Translations;United States Department of Veterans Affairs;Universities;Variant;Veterans;Work


NIH_SPENDING_CATS: Cancer

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: CANCER RESEARCH UNITED KINGDOM

ORG_ZIPCODE: E20 1JQ

PI_NAMEs: SCOTT, DAVID  (contact)

PROGRAM_OFFICER_NAME: KURTZ, ANDREW J

PROJECT_TITLE: Cancer Grand Challenges: Operations Management Application


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: HANOVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Uncontrolled motivation and mood underlies major depression and bipolar disorder. Within brain reward  circuitry, co-release of both inhibitory and excitatory signals by the same population of neurons is a newly  identified mechanism, and its functional role is not completely understood. This proposal seeks to pinpoint  how these co-releasing neurons normalize rewarding and aversive motivational states in an effort to  identify potential new therapeutic targets that alleviate symptoms of depression or mania.

PI_NAMEs: WARLOW, SHELLEY MAY (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;American;Amygdaloid structure;Axon;Behavioral;Behavioral Assay;Bipolar Depression;Bipolar Disorder;Brain;Calcium;cell type;Cells;college;Complex;Compulsive Behavior;Data;depressive symptoms;Disease;Dissection;Dopamine;dopaminergic neuron;experience;experimental study;Fiber;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Habenula;Image;in vivo;in vivo calcium imaging;Incentives;insight;Lateral;Life;Major Depressive Disorder;Manic;Mediating;Membrane Potentials;Mental Depression;Modeling;Monitor;Moods;motivated behavior;Motivation;Mus;Negative Reinforcements;neural circuit;Neurons;neuropsychiatric disorder;Neurotransmitters;new therapeutic target;optogenetics;patch clamp;Phase;Photometry;Physiological;Physiology;Population;Population Heterogeneity;Positioning Attribute;Positive Reinforcements;postsynaptic;professor;programs;protein kinase C-delta;psychologic;Psychological reinforcement;reduce symptoms;Regulation;Research;response;reward circuitry;Rewards;Role;Science;Shapes;Signal Transduction;skill acquisition;Somatostatin;Structure;Sucrose;tenure track;Testing;therapeutic target;therapeutically effective;Training;transmission process;Update;Ventral Tegmental Area

PROJECT_TITLE: Balancing motivation through VTA GABA/Glutamate co-transmission


ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PI_NAMEs: SCHWARB, HILLARY  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Adult;Affect;Arrhythmia;Attention;Behavior;Behavioral;Biological;Brain;Clinical;Cognitive;Community Integration;cost;Data;Decision Making;dentate gyrus;Development;diagnostic biomarker;Economic Burden;effective intervention;Evaluation;flexibility;Foundations;Functional disorder;Future;Goals;Health;Hippocampus;Human;Impaired cognition;Impairment;in vivo;Individual;Intervention;Investigation;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Matched Group;Measures;mechanical properties;Memory;Memory impairment;memory process;Mental Depression;Mental Health;Methamphetamine;Methamphetamine misuse;methamphetamine use;Methamphetamine use disorder;methamphetamine user;Participant;Performance;Phase;physical conditioning;Population;pre-clinical;Psychoses;Recovery;Research;Resolution;Rodent;Rural drug addiction;Scanning;Stroke;Structure;System;Tissues;tool;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Hippocampal Alteration in Methamphetamine Misuse

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C2)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: PROJECT NARRATIVE Turkana is a historically marginalized county in Kenya due to nomadic lifestyle of the people, has high HIV prevalence, increasing burden of non-communicable including among people living with HIV and limited opportunities for advanced education and scientific research. This application aims to train a diverse group of trainees in advanced research methods and support them to conduct mentored research. The training will promote locally relevant research, enhance diverse perspectives and lived experiences in research leading to identification of innovative strategies to optimize NCD prevention, diagnosis and treatment for PLWH in Turkana and Kenya as a whole.

PI_NAMEs: FARQUHAR, CAREY ;KINUTHIA, JOHN  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adherence;Administrative Supplement;Age;AIDS prevention;arid land;Award;Awareness;Biometry;Caring;Communities;comorbidity;County;Coupled;Data;Data Analyses;Diabetes Mellitus;Diagnosis;Disease;disorder prevention;Education;Educational Background;Epidemiology;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Grant;Health;Health Personnel;HIV;Home;Hospitals;Hypertension;implementation science;innovation;interest;Kenya;Life Style;Lived experience;marginalization;Medical;Mental Depression;Mental Health;Mentors;Mentorship;mortality risk;Persons;population based;Populations at Risk;Prevalence;Prevention;programs;Quality of life;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;screening;skills;statistics;Surveys;Time;Training;Underserved Population;Universities;uptake;Viral;Washington

PROJECT_TITLE: Promoting diverse perspectives in research to optimize integration of NCDs and HIV care in Kenya


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: No PHR

PI_NAMEs: MARTINO, STEVE ;ROSEN, MARC I (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: implementation facilitation;military service;Pain management;screening, brief intervention, referral, and treatment;Veterans

PROJECT_TITLE: Implementation Facilitation of Screening, Brief Intervention, and Referral to Treatment for Pain Management for Veterans Separating from Military Service


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE In our modern food environment, we are constantly exposed to compelling food cues – such as the smell and taste of highly palatable foods – that interact with our physiology to promote feeding and weight gain. Here, we take a unique approach to understanding obesity by (1) evaluating the power of taste, smell, and nutrient neural circuits in modifying eating behavior, and (2) uncovering how sensory and nutritive information is integrated in the brains of awake behaving mice to predict future weight gain. Successful completion of this proposal will transform our understanding of how our brain and environment interact to promote overeating and obesity.

PI_NAMEs: ALHADEFF, AMBER L (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: awake;Award;Biology;Body Weight;Body Weight decreased;Brain;Calcium;career;Chemicals;collaborative environment;Cues;Eating;Eating Behavior;Environment;experience;Exposure to;feeding;Feeding behaviors;Food;food environment;Food Interactions;Food Preferences;Future;Hyperphagia;Individual;Individual Differences;innovation;Maps;Modernization;Monitor;Mus;neural;neural circuit;Neurobiology;neuromechanism;Neurons;Neurosciences;novel strategies;Nutrient;Obesity;Pathway interactions;Pattern;Pennsylvania;pharmacologic;Physiology;Process;Productivity;Property;Research;research and development;response;Satiation;Sensory;sensory input;sensory integration;sensory stimulus;Signal Transduction;Smell Perception;Taste Perception;therapeutic target;United States;United States National Institutes of Health;Universities;Weight Gain

PROJECT_TITLE: Harnessing sensory food circuits to influence feeding behavior


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Despite extensive advancements in the field of clinical and translational research, numerous roadblocks continue to stand in the way of delivering clinical interventions more efficiently, effectively, and equitably. In this application, Harvard Catalyst is proposed as a clinical and translational science laboratory that will work to develop, demonstrate, and disseminate innovations capable of overcoming these roadblocks and, ultimately, improving human health. Harvard Catalyst will leverage the unique expertise of 17 affiliated, but independent, institutions across the Boston biomedical ecosystem to address these challenges, placing particular emphasis on supporting early stage and underrepresented in medicine investigators and their teams.

PI_NAMEs: NADLER, LEE MARSHALL (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Adopted;Boston;catalyst;Center for Translational Science Activities;Clinical;Clinical Data;Clinical effectiveness;clinical implementation;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials Network;cohort;Collaborations;Communities;community engagement;Community Health;community partners;Competence;COVID-19 pandemic;Democracy;digital;Ecosystem;education research;education resources;Effectiveness;EHR research;Electronic Health Record;Elements;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;first-in-human;Geography;Goals;Health;health inequalities;Health Sciences;Healthcare;Human;improved;Informatics;Infrastructure;innovation;insight;Institution;Institutional Review Boards;interoperability;Intervention;Laboratories;Leadership;Learning;Logic;Measures;Medical;medical schools;Medicine;meetings;Mentors;Methodology;Methods;Modeling;Multi-Institutional Clinical Trial;Ohio;open data;open source;Oregon;Output;patient population;Population Heterogeneity;pre-clinical;Process Assessment;prototype;Public Health Informatics;Public Health Schools;Research;research and development;Research Design;Research Personnel;Resources;Safety;Science;Secure;sharing platform;Special Population;success;tool;Training;translational barrier;Translational Research;Vision;Work

PROJECT_TITLE: Harvard Clinical and Translational Science Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE People released from prison suffer poor cardiovascular health, high rates of cardiovascular mortality, and other health problems. We propose to examine organizational policies and practices in healthcare systems that affect people’s access to quality healthcare after release from prison. This project will assist healthcare systems and other organizations in addressing the health care gap for people released from prison.

PI_NAMEs: DAUGHERTY, STACIE LUTHER (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: access disparities;Address;Adult;Affect;Area;Attitude;behavioral health;Black Populations;Black race;Cardiology;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care outcomes;Clinic Visits;cohort;Colorado;Communities;community academic partnership;community advisory board;community organizations;Criminal Justice;Data;Databases;Disadvantaged;Discrimination;Eligibility Determination;Emergency Situation;Employment;Enrollment;Ethnic Origin;Event;Exposure to;Face;Focus Groups;follow-up;Frontline worker;Future;General Population;Goals;Health;health assessment;health care availability;health care quality;health care service organization;health care service utilization;health disparity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;High Prevalence;Hospitalization;Housing;housing instability;Imprisonment;Improve Access;improved;Indigenous;Individual;innovation;Intervention;Interview;Investigation;Link;Longitudinal cohort study;Measures;Medicaid;mortality;multidisciplinary;Observation in research;Organizational Policy;Outcome;Patients;peer;people of color;Persons;Policies;poor health outcome;Population;prevent;primary outcome;Prisons;Procedures;programs;prospective;Race;racial disparity;racism;Recommendation;Recording of previous events;Research;Research Methodology;safety net;secondary outcome;segregation;Services;social health determinants;social stigma;Structural Racism;System;Testing;Visit;Writing

PROJECT_TITLE: Healthcare Organizational Structural Conditions and the Health of People Recently Released from Prison