NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

PHR: Pulmonary macrophages and fibroblasts are critically involved in lung homeostasis as well as inflammatory and fibrotic diseases. In this proposal, the principal investigator seeks to continue a highly productive and innovative investigative program designed to provide new insights into the molecular regulation of these two cell types in health and disease. These insights will provide a foundation for new therapeutic strategies widely applicable to a variety of lung diseases.

PI_NAMEs: PETERS-GOLDEN, MARC L (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Allergens;Alveolar Macrophages;Apoptosis;Award;Biology;Bortezomib;bronchial epithelium;cancer cell;career;cell type;Cells;Cellular biology;CISH gene;clinical practice;Cyclic AMP;design;Dinoprostone;Disease;Education;Epithelial Cells;extracellular vesicles;Fibroblasts;Foundations;FOXM1 gene;Funding;Genetic Transcription;Health;Homeostasis;Inflammatory;innovation;insight;Leadership;Liposomes;Lung;Lung Diseases;Macrophage;Malignant - descriptor;Mediating;Mentors;Molecular;Molecular Biology;novel;novel therapeutic intervention;Pathogenicity;Pharmaceutical Preparations;Physicians;Population;Principal Investigator;Process;Productivity;programs;Proliferating;Property;Proteome;Proto-Oncogenes;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Qualifying;Regulation;Reporting;Research;Research Support;Resistance;Role;Science;Scientist;Seminal;Services;Signal Transduction;Stimulus;transcription factor;tumorigenic;United States National Institutes of Health

PROJECT_TITLE: Novel Functions of Lung Macrophages and Fibroblasts in Pulmonary Inflammation and Fibrosis


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Friedreich's ataxia (FRDA) is a progressive neurodegenerative disease caused by reduced expression of the mitochondrial protein Frataxin (FXN). The G130V pathogenic point mutation inhibits production of mature FXN and gives rise to an atypical FRDA phenotype in patients. Realization of this project will define molecular mechanisms linking frataxin processing with clinical presentation of the disease and will be important for FRDA patients with point mutations as well as GAA expansions.

PI_NAMEs: NAPIERALA, MAREK  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Affect;Afferent Neurons;Alleles;Amino Acids;Anabolism;Ataxia;autosome;axonal degeneration;Axonal Transport;Binding;Biochemical;Biophysics;Cell model;Cell Physiology;Cells;Characteristics;Clinical;Compensation;Complex;Data;design;Disease;Disease Progression;Electron Microscopy;Enzymes;Exhibits;experience;experimental study;frataxin;Friedreich Ataxia;Genes;Genotype;Glycine;Hereditary Spastic Paraplegia;Heterozygote;Impairment;In Vitro;induced pluripotent stem cell;Introns;Iron;Knowledge;Link;lipid metabolism;Lower Extremity;Mediating;Missense Mutation;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Molecular Sieve Chromatography;mouse model;multiple myeloma M Protein;mutant;Mutation;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;NMR Spectroscopy;Nonsense Mutation;novel;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient subsets;Patients;Peptide Hydrolases;Phenotype;Point Mutation;Positioning Attribute;preservation;Production;Property;Protein Isoforms;Proteins;Reagent;Respiration;response;Sampling;Sensory;Severities;spasticity;Speech;Sulfur;Symptoms;Testing;Therapeutic;therapy development;Translating;Trinucleotide Repeats;Upper Extremity;Valine;Work

PROJECT_TITLE: Defining the impact of Frataxin point mutations on Friedreich's ataxia pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: This project seeks to uncover the molecular mechanisms that control functional plasticity of gap junctions that form electrical synapses in neurons. Electrical synapses play important roles in development, sensory adaptation, learning and memory, and motor control, and in pathological states can contribute to neurological disorders and ischemic injuries. Identification of mechanisms that control their plasticity will allow the development of targeted therapies for problematic neurological disorders.

PI_NAMEs: O'BRIEN, JOHN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Actins;Amacrine Cells;autism spectrum disorder;Behavior;Binding;Binding Proteins;Biological Models;Brain;Brain Injuries;C-terminal;calmodulin-dependent protein kinase II;Cell Culture System;Cell Culture Techniques;Cells;Central Nervous System;Chemicals;Communication;Complex;connexin 36;Coupling;Cytoskeleton;Data;Development;Disease;Dominant-Negative Mutation;Dopamine D1 Receptor;Electrical Synapse;Elements;Etiology;experimental study;functional plasticity;Gap Junctions;Glutamates;Goals;human disease;In Vitro;inhibitor;insight;Intervention;ischemic injury;Knock-in Mouse;Knowledge;Label;Learning;Link;Mediating;Memory;mimetics;Molecular;motor control;Mus;mutant;Nerve Degeneration;Nervous System;Nervous System Disorder;neural network;Neurons;Pathologic;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;Process;protein complex;Protein phosphatase;Proteins;Proteomics;Receptor Signaling;Regulation;Research Project Grants;Resources;Rest;Retina;Role;scaffold;Scaffolding Protein;Seizures;Sensory;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;small molecule;Synapses;synthetic peptide;System;targeted treatment;Techniques;Testing;visual adaptation;visual control;Work

PROJECT_TITLE: Regulation of Retinal Gap Junctions

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE UT Southwestern proposes to maintain a Network Lead Academic Participating Site (LAPS) for the NCI National Clinical Trials Network (NCTN). As an NCTN Network LAPS, UT Southwestern will provide scientific leadership by helping to develop and conduct clinical trials in association with adult Network Groups and will contribute substantial accrual to clinical trials conducted across the entire NCTN. Key strengths of our site relevant to this effort include a history of leadership in multiple cooperative groups and excellent accrual to cooperative group trials (including ethnic and racial minorities), innovative basic research and drug discovery (which can be translated to clinic trials), an Advanced Imaging Research Center, and our unique position as the only NCI designated Comprehensive Cancer Center and academic medical center in the fourth largest metropolitan area in the country.

PI_NAMEs: GERBER, DAVID ERIC (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Academic Medical Centers;Administrative Supplement;Adult;African American;Area;base;Basic Science;Bioinformatics;Cancer Center;career development;Categories;Clinic;Clinical Investigator;Clinical Research;clinical research site;clinical trial enrollment;Clinical Trials;Clinical Trials Network;Colorectal Cancer;Comprehensive Cancer Center;Conduct Clinical Trials;cost;Country;design;Disease;drug discovery;Eligibility Determination;Enrollment;ethnic diversity;ethnic minority;Faculty;Funding;Grant;Growth;Health Resources;Hispanic;Hospitals;Image;innovation;Investigational Therapies;Lead;Leadership;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;medical schools;member;Mentors;metropolitan;National Clinical Trials Network;NCI-Designated Cancer Center;novel;Outcomes Research;participant enrollment;Patient-Focused Outcomes;Patients;Population;Population Heterogeneity;Population Research;Positioning Attribute;pressure;Process;programs;Publications;Race;racial minority;Radioisotopes;Recording of previous events;Renal Carcinoma;Research;Role;screening;Site;Texas;Therapeutic;Time;timeline;Translating;Universities

PROJECT_TITLE: UT Southwestern NCI National Clinical Trials Network Lead Academic Site


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Rates of Alzheimer’s Disease and its Related Dementias (ADRD) are approximately 3 times higher in Indigenous populations who already shoulder a range of health inequities including a disproportionate share of age-related diseases. Our research uses community-based, qualitative research to understand how culture and community context influence the impacts of ADRD in diverse American Indian and First Nations communities. By documenting the lived experience of ADRD in Indigenous populations this research will contribute to the knowledge base necessary to create culturally appropriate ADRD health diagnostics, caregiving practices, health promotion and education tools.

PI_NAMEs: JACKLIN, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;American Indians;Awareness;Caregivers;caregiving;Caring;Clinical;Communities;Community Actions;community based participatory research;community-level factor;comorbidity;Coupled;Data;Databases;Dementia;dementia burden;Development;Diagnosis;Diagnostic;Disease;Disparity;early onset;Economics;Education;Elements;Ethnography;experience;Eye;Funding;Goals;Guidelines;Health;health disparity;health inequalities;Health Promotion and Education;Health Resources;Health system;Healthcare;Healthcare Systems;improved;improved outcome;Indigenous;Indigenous American;Inequity;innovation;Interview;Investments;Island;Knowledge;knowledge base;knowledge translation;Life Cycle Stages;Light;Literature;Lived experience;Methods;Minnesota;Monitor;Native-Born;Oneida;Ontario;outreach;participant observation;Pathway interactions;personalized approach;Persons;phenomenological models;Population;Procedures;Qualitative Research;Quality of life;Recording of previous events;Research;Research Infrastructure;Resources;Services;Shapes;Shoulder;Site;social;social health determinants;Staging;Structure;Symptoms;tool;Training Activity;video module;Wisconsin

PROJECT_TITLE: Indigenous Cultural Understandings of Alzheimer's Disease and Related Dementias - Research and Engagement (I-CARE)

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Age-related macular degeneration (AMD) is a leading cause of blindness worldwide; however, there is a lack of treatment for dry AMD and to halt its progression to the late, blinding forms because the underlying causes of AMD development and progression are unclear. This study utilizes a novel, comprehensive methodology called “metabolomics” (i.e. the study of small molecules) to investigate the mechanisms of AMD and to serve as the basis for future biomarkers of this condition and its progression in easily accessible biofluids (blood and urine). Our work has the potential to: (i) give unique insights into the causes of AMD; (ii) significantly impact AMD diagnosis and risk assessment; and (iii) accelerate the development of novel strategies for earlier treatment and prevention of this blinding condition.

PI_NAMEs: HUSAIN, DEEBA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Address;Affect;Age;age difference;age effect;age related biomarkers;Age related macular degeneration;Alzheimer's Disease;Biological;Biological Markers;biomarker identification;Biometry;Blindness;Blood;Blood specimen;Characteristics;Clinical;cohort;Cohort Studies;comparison control;Complex;Cross-Sectional Studies;Data;Databases;design;Developed Countries;Development;Diagnosis;Disease;Disease Progression;disorder of macula of retina;Early Intervention;Early treatment;Economic Burden;Elderly;Environmental Exposure;Environmental Risk Factor;Exhibits;Eye;Fasting;Functional disorder;Future;gene interaction;Genes;Genetic;genetic epidemiology;genetic profiling;Genetic Transcription;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Glycerophospholipids;Goals;Heritability;human tissue;improved;In Situ;Individual;insight;Knowledge;Life Style;Link;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Mediation;metabolic profile;metabolome;metabolomics;Methodology;multidisciplinary;Nature;Nonexudative age-related macular degeneration;novel;novel strategies;Pathogenesis;Pathway interactions;Patients;Performance;Phenotype;Plasma;potential biomarker;precision medicine;Prevention;preventive intervention;profiles in patients;progression marker;prospective;Proteome;Protocols documentation;Purines;Quantitative Trait Loci;recruit;Reporting;Risk;Risk Assessment;risk prediction;Role;Sampling;screening;Severities;Signal Transduction;Single Nucleotide Polymorphism;small molecule;socioeconomics;Sphingolipids;Statistical Methods;statistics;study population;Tissues;tool;Transcription Process;transcriptome;urinary;Urine;Work

PROJECT_TITLE: Metabolomics a Novel Tool for Investigating the Pathogenesis of Age-related Macular Degeneration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Aging;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public Health Relevance / Narrative: Glaucoma is leading cause of irreversible vision loss, affecting an estimated 76 million people worldwide. This project aims to fill knowledge gaps concerning the role of an emerging but still poorly understood protein, LTBP2, in eye structure and pressure regulation in glaucoma. Results of these studies will serve as a foundation for the development of innovative new glaucoma treatment strategies, to help preserve vision in glaucoma patients.

PI_NAMEs: MCLELLAN, GILLIAN JANE (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Address;Adult;Affect;Age;Angiography;Animal Model;Animals;Anterior;aqueous;Aqueous Humor;Binding Proteins;Biological;Biological Assay;Biology;Birth;Blindness;Catalogs;causal variant;cell behavior;Cell Culture Techniques;Cell Proliferation;Cell-Matrix Junction;Cells;Cellular biology;Childhood;Ciliary epithelium;Clinical;Complex;crosslink;Cytoskeleton;Data;Deposition;design;Development;differential expression;Distal;early onset;Ensure;Equilibrium;Extracellular Matrix;Eye;Family Felidae;Felis catus;Fibrosis;Fluorescence Microscopy;Focal Adhesions;Foundations;Functional disorder;Future;Gene Expression;Genes;Genetic Models;Glaucoma;Goals;Heterozygote;Homeostasis;Homologous Gene;Human;Hydrophthalmos;Image;In Situ;In Vitro;in vivo;Incubated;infancy;Inherited;innovation;interest;knock-down;Knock-out;Knowledge;Label;Lasers;Life;Light;Mediating;MFAP1 gene;Microfibrils;Microfilaments;Microscopy;Modeling;Molecular;Morphology;morphometry;Mutation;novel;Open-Angle Glaucoma;optic nerve disorder;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;perinatal period;Persons;Phenotype;Physiologic Intraocular Pressure;Physiological;Physiology;Play;postnatal;preservation;pressure;prevent;primary congenital glaucoma;Process;Production;Proliferating;protein expression;Protein Isoforms;Proteins;public health relevance;Publishing;Recombinants;Regulation;Reporting;Resistance;Role;Signal Transduction;Small Interfering RNA;Stains;Structure;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thick Filament;Third Pregnancy Trimester;Tissues;Trabecular meshwork structure;Transcript;transcriptomic profiling;transcriptomics;Transforming Growth Factor beta;Transgenic Mice;translational model;translational potential;Translational Research;treatment strategy;Validation;vector control;Vinculin;Vision;Western Blotting;Work

PROJECT_TITLE: The role of LTBP2 in glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Neurosciences;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: This training program will enhance the research career trajectories of a community of postdoctoral and junior faculty including women and those from groups historically underrepresented in the biomedical and behavioral sciences through a coordinated set of programs focused on mentorship, skills development, and research experiences. The underrepresentation of women and persons excluded due to ethnicity and race (PEERs) has many causes; this program addresses the attrition of these groups from neuroscience research at senior postdoctoral and junior faculty levels. Critical aspects of the program include building a community of lifelong mentors and peers; practical skills including incorporating cutting edge methods, effective communication, networking, and management; and individualized support to retain outstanding scientists in neuroscience and to accelerate the pace of meaningful discoveries and cures.

PI_NAMEs: AIZENMAN, CARLOS D;LIPSCOMBE, DIANE  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acceleration;Address;Area;Basic Science;Behavioral Sciences;Biological Sciences;Biomedical Research;Brain;Brain Diseases;career;career development;Career Mobility;Climate;Clinical Sciences;cohort;college;Communication;Communities;Computers;Country;Data;Decision Making;Diagnosis;Discipline;Disease;diversity and inclusion;Doctor of Philosophy;Education;Education Projects;Educational Status;Ensure;Equity;equity, diversity, and inclusion;Ethnic Origin;Exclusion;experience;Faculty;Feedback;Female;Funding;graduate student;Growth;improved;Individual;Injury;innovation;Institution;Knowledge;men;Mentors;Mentorship;Methodology;Methods;National Institute of Neurological Disorders and Stroke;Nervous System;Neurosciences;Neurosciences Research;new technology;Occupations;Participant;peer;Persons;Phase;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Professional Competence;programs;Qualifying;Race;recruit;Research;research and development;Research Personnel;Research Support;Science;Scientist;Self Efficacy;senior faculty;Series;skill acquisition;skills;stem;STEM field;Structure;Students;success;Surveys;System;Talents;technology development;Textiles;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: Advancing the Research Careers of Women and PEERs in Brain Science


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative/Public Health Statement: This project is relevant to public health in focusing on developing and evaluating predictive algorithms for glaucoma progression, which are necessary to tailor treatment approaches to individual glaucoma patients' needs and achieve optimal treatment outcomes to prevent blindness. The powerful artificial intelligence techniques we will develop and use for large-scale data from electronic health records can be extended to include a wide variety of data sources and shared with the research and clinical community to answer ophthalmic questions in many domains. In supporting personalized medicine for glaucoma patients to improve ophthalmic outcomes, the proposed research is relevant to the NEI's mission to protect and prolong vision.

PI_NAMEs: WANG, SOPHIA YING (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adherence;Advisory Committees;Affect;Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;biomedical informatics;Blindness;Calibration;career;Career Mobility;Characteristics;Clinic;Clinical;Clinical Data;clinical data warehouse;clinically relevant;Code;cohort;Communities;Complex;Computers;Data;data sharing;Data Sources;Databases;demographics;Development;Disease;Documentation;Early identification;electronic health information;Electronic Health Record;Ensure;Evaluation;evidence base;Future;Glaucoma;glaucoma surgery;Goals;Health;high risk;Image;improved;Individual;individualized medicine;Informatics;innovation;insight;Intervention;large scale data;machine learning model;machine learning prediction;Measurement;medication compliance;Medicine;Mentorship;Methods;Mission;model building;Modeling;Names;Natural Language Processing;Operative Surgical Procedures;ophthalmic examination;Ophthalmology;optimal treatments;Outcome;Patient Care;Patients;Pattern;Performance;personalized medicine;personalized predictions;Persons;Pharmaceutical Preparations;Physicians;Physiologic Intraocular Pressure;precision medicine;prediction algorithm;predictive modeling;prevent;Process;Productivity;progression risk;prospective;Public Health;Readability;Recording of previous events;Registries;Relaxation;Research;Research Personnel;Scientist;Stable Disease;Structure;structured data;success;support tools;Techniques;Technology;Testing;Text;tool;Translating;Treatment outcome;treatment pattern;Variant;Vertebral column;Veterans Health Administration;Vision;Work

PROJECT_TITLE: Personalized Predictions for Glaucoma Progression Using Artificial Intelligence for Electronic Health Records


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Depression is the second leading cause of disability worldwide, due partly to the fact that existing antidepressants are not effective for all patients and it is often challenging to match individual patients to the treatments that are most likely to help them. This project will test a new strategy for using fMRI brain scans to predict antidepressant response and assist clinicians in choosing which of two antidepressant treatments— transcranial magnetic stimulation targeting one of two depression-related brain areas—is most likely to benefit an individual patient.

PI_NAMEs: GUNNING, FAITH M;LISTON, CONOR M (contact);WILLIAMS, NOLAN R.

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Accounting;Aftercare;Amygdaloid structure;Anatomy;Anhedonia;anti-depressive agents;Anxiety;anxious;Area;arm;Arousal;Behavior assessment;Biological Markers;biomarker discovery;biotypes;Brain;Brain scan;Clinical;Clinical assessments;clinical predictors;comparative efficacy;confirmatory trial;Corpus striatum structure;Data;depressive symptoms;Diagnosis;Diagnostic;Dimensions;disability;Disease remission;disorder subtype;efficacy evaluation;electric field;emotion regulation;Exhibits;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Heterogeneity;improved;indexing;Individual;Individual Differences;individual patient;Intervention;Left;machine learning method;Major Depressive Disorder;Maps;Measures;Medical;Mental Depression;Methods;Modeling;Motivation;novel;Patients;Pattern;pharmacologic;Pharmacotherapy;predicting response;Prediction of Response to Therapy;predictive marker;Prefrontal Cortex;Publishing;Randomized;repetitive transcranial magnetic stimulation;Research Domain Criteria;Resistance;response;Rest;Scanning;Selection for Treatments;Site;standard of care;Symptoms;System;Testing;Time;tractography;Transcranial magnetic stimulation;treatment response;treatment-resistant depression;Work

PROJECT_TITLE: Efficacy of biomarker-guided rTMS for treatment resistant depression


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In the proposed project, we will develop and apply population genetic tools to detect and disentangle signals of population structure and adaptation in contemporary and ancient genomic datasets. Identifying monogenic or polygenic adaptive genetic variation is a key step towards understanding the genetic mechanisms affecting disease prevalence in different population groups and unraveling the genetic architecture underlying complex genetic diseases. The tools will use explicit models of the underlying population genetic processes to detect the genomic patterns characteristic to complex migration histories and adaptive genetic variation.

PI_NAMEs: STEINRUECKEN, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Accounting;Address;Affect;Altitude;Bubonic Plague;Characteristics;Collaborations;Complement;Complex;Computer software;Data;Data Set;detection method;Disease;disorder risk;DNA;Environment;Europe;European;Exhibits;expectation;Exposure to;flexibility;Gene Frequency;Genealogy;Genetic;genetic approach;genetic architecture;Genetic Diseases;Genetic Drift;Genetic Materials;Genetic Models;Genetic Predisposition to Disease;Genetic Processes;Genetic study;Genetic Variation;Genome;genomic data;Genomic Segment;genomic signature;genomic variation;Genomics;Genotype;Historical Demography;Human;human data;Hypoxia;Immune response;improved;Individual;individual patient;Lactase;large datasets;Link;Location;markov model;Medical;Methods;migration;Modeling;Modernization;Motivation;Noise;novel;novel strategies;Organism;pandemic disease;pathogen;Pattern;Phenotype;Population;Population Genetics;Population Group;Population Sizes;Positioning Attribute;pressure;Prevalence;Process;public database;Recording of previous events;Research Personnel;response;Sampling;Series;Shapes;Signal Transduction;Structure;Time;tool;trait;Variant

PROJECT_TITLE: Population genetic methods to detect population structure and adaptation using modern and ancient genomic datasets

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Pediatric;Precision Medicine;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Children with pediatric chronic non-infectious uveitis (NIU) are treated with methotrexate as the first line immune- suppressant despite failure rates of as high as 50%. This research will identify clinical, imaging and biologic risk factors that predict a child’s responsiveness to methotrexate. It is anticipated that results from this study will help us select the most optimal initial treatment for children with NIU that will control inflammation quickly, minimize ocular damage, and improve childhood vision.

PI_NAMEs: ANGELES-HAN, SHEILA THERESE (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;Anterior;anterior chamber;Biological;Biological Products;Biological Response Modifier Therapy;Biometry;Blindness;Blood specimen;Cells;Child;Child Health;Childhood;Chronic;Chronic Childhood Arthritis;Clinical;clinical examination;Cystoid Macular Edema;Data;Decision Making;demographics;design;Diagnosis;Disease;disease heterogeneity;Drops;effective therapy;Enrollment;experimental study;Extravasation;Eye diseases;Failure;Fluorescein;Fluorescein Angiography;follow-up;gene discovery;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Glucocorticoids;Goals;high risk;Image;Imaging Device;imaging modality;Immune;Immunologist;Immunology;improved;Individual;Inflammation;Inflammatory;innovation;Investigation;Laboratories;Location;Methotrexate;Modality;Monitor;Nomenclature;ocular imaging;ophthalmic examination;Ophthalmologist;Ophthalmology;Optical Coherence Tomography;Oral;Outcome;Patient risk;Patients;peripheral blood;personalized medicine;Pharmaceutical Preparations;predicting response;Prediction of Response to Therapy;Predictive Factor;predictive signature;prevent;prospective;quantitative imaging;Research;response;Rheumatism;rheumatologist;Rheumatology;Risk;Risk Factors;Safety;standard care;Standardization;success;Systemic disease;Testing;Therapeutic;Therapeutic Effect;transcriptome sequencing;translational study;treatment optimization;treatment response;treatment strategy;United States National Institutes of Health;Uveitis;Vision;Whole Blood;Work

PROJECT_TITLE: Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: OVERALL – PROJECT NARRATIVE The Johns Hopkins Alzheimer's Disease Research Center is an integrated program aimed at finding improved treatments for patients with Alzheimer disease and related disorders. Complimentary activities within the center include clinical and basic research studies that incorporate state-of-the art methodologies, and contribute significantly to national programs. We are dedicated to training the next generation of investigators and to reaching out to the community to improve understanding about these diseases.

PI_NAMEs: ALBERT, MARILYN S. (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Baltimore;Basic Science;Behavioral;Biological Markers;Biological Models;Biostatistics Core;brain tissue;Cancer Education Grant Program;Center Core Grants;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Data;Data Analyses;data management;Dedications;design;Development;Disease;Education;education research;educational atmosphere;Enrollment;Environment;Event;Fostering;Funding;Funding Agency;Future;Goals;Grant;Growth;Human;human model;improved;Individual;innovation;insight;Institution;interest;Intramural Research Program;Joints;K-Series Research Career Programs;Laboratories;Leadership;Link;Longitudinal Studies;meetings;Mentorship;Methodology;Methods;Mind;Molecular;National Institute on Aging;neuropathology;Neurosciences;next generation;outreach;Participant;Patient Care;Patients;Phase;Pilot Projects;pre-clinical;Process;Program Description;programs;recruit;Research;Research Personnel;research study;Research Training;Resources;Scientific Advances and Accomplishments;senior faculty;Source;Strategic Planning;Talents;Therapeutic;Tissue Banks;Tissues;Training;Training Support;Translating;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Advisory Committees;Alzheimer's Disease;Animal Welfare;Biological Markers;catalyst;Clinical;Communities;data management;data sharing;Dedications;Development;Disease;Education and Outreach;education research;Environment;Fostering;Funding;Goals;Growth;human subject protection;Image;Individual;Infrastructure;innovation;International;Leadership;member;Mentors;model organism;National Institute on Aging;neuropathology;outreach;Policies;Positioning Attribute;Productivity;programs;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Scientist;Specimen;statistics;Strategic Planning;success;Training;United States National Institutes of Health;Utilization Review;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LYKETSOS, CONSTANTINE G (contact)

PROJECT_TERMS: African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Autopsy;Biological;Biological Markers;biomarker development;Blood;Brain;Brain imaging;brain magnetic resonance imaging;brain tissue;Cerebrospinal Fluid;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cohort;Collection;Complex;Consent;cooperative study;Data;data sharing;Dementia;Diagnosis;Disease;education research;Evaluation;Frontotemporal Lobar Degenerations;Funding;Genotype;Image;Institutional Review Boards;interest;Investigation;Lead;Liquid substance;Measurement;Medical;meetings;Minority;Mission;MRI Scans;neuroimaging;Neurologic;neuropathology;Neuropsychology;operation;outreach;Participant;participant enrollment;Pathologic;Patients;Phase;recruit;repository;Research;Research Activity;Research Design;Research Institute;Research Personnel;Research Subjects;Resource Sharing;Resources;Sampling;Site;Specimen;Standardization;Study Subject;success;Therapeutic Clinical Trial;therapy development;Training;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Core B: Clinical Core


PI_NAMEs: BANDEEN-ROCHE, KAREN J. (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;American;analytical method;archive data;Area;Biological Markers;biomarker discovery;Biometry;Brain imaging;Clinical;Collaborations;Consultations;Data;Data Analyses;data archive;data cleaning;Data Collection;Data Coordinating Center;data integration;data management;Data Set;data submission;database design;Decision Making;Dementia;design;Development;Disease;education research;expectation;experience;Faculty;forging;Funding;Goals;Guidelines;Human Resources;Impaired cognition;Individual;innovation;insight;Institution;Leadership;Measures;meetings;member;Mentors;Mentorship;Methods;Monitor;neuroimaging;neuropathology;next generation;novel;Older Population;outreach;Personnel Management;Process;programs;Protocols documentation;Research;Research Design;Research Personnel;Research Support;Role;Scholarship;Science;Scientist;Site;skills;Statistical Data Interpretation;statistics;Students;Training

PROJECT_TITLE: Core C: Data Management and Statistics Core


PI_NAMEs: TRONCOSO, JUAN  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Autopsy;Biochemistry;Biological;Biological Markers;biomarker development;Brain;Brain Diseases;brain tissue;Clinic;Clinical;clinical center;clinical diagnosis;Cognitive;cohort;Collaborations;Communities;comorbidity;Consensus;Consultations;Data;Databases;Dementia;Development;Diagnosis;Diagnostic;Doctor of Philosophy;Drug or chemical Tissue Distribution;education research;Electron Microscopy;Enrollment;Etiology;Evaluation;Faculty;Family;Genetically Engineered Mouse;Goals;Hippocampus;Histology;Human;Human Resources;Image;immunocytochemistry;Institution;interest;Investigation;Liquid substance;Molecular Biology;Morphology;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurology;neuropathology;outreach;Pamphlets;Participant;Pathogenesis;Pathologic;Physicians;Preparation;Progress Reports;Publications;recruit;Reporting;Research;Research Personnel;Resources;Services;Source;Specimen;Structure;symposium;Tissue Banks;tissue preparation;Tissues;Training;Update;Work

PROJECT_TITLE: Core D: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: PETTIGREW, CORINNE  (contact)

PROJECT_TERMS: Address;African American;African American population;aged;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Autopsy;Baltimore;Biological Markers;Brain;Catchment Area;Censuses;Clinical;Clinical Research;Clinical Research Associate;Collaborations;Communities;community engagement;Community Health Education;community partnership;community setting;Data;Databases;design;Disease;Education;Education and Outreach;educational atmosphere;elementary school;experience;Focus Groups;Fostering;Funding;Goals;improved;Internships;junior high school;Knowledge;Link;Minority;minority communities;Minority Enrollment;Minority Participation;minority student;outreach;Pamphlets;Participant;participant retention;Population;Procedures;programs;Publishing;recruit;Reporting;Research;Research Project Grants;research study;retention rate;Role;Schools;success;Time;Update;web site;Work

PROJECT_TITLE: Core E: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BAKKER, ARNOLD  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Apolipoprotein E;Biological Assay;Biological Markers;Blood;Blood specimen;Brain imaging;brain magnetic resonance imaging;Brain scan;Cerebrospinal Fluid;Clinical;Collaborations;Collection;Communities;Data;Databases;DNA;Education;Educational Materials;Enrollment;Functional Magnetic Resonance Imaging;Funding;Genotype;Goals;Grant;Hippocampus;Image;interest;Magnetic Resonance Imaging;Maps;Measures;member;Mentors;Methods;Mission;MRI Scans;novel;novel marker;Participant;participant enrollment;Peripheral Blood Mononuclear Cell;Phase;Plasma;Positron-Emission Tomography;Predisposition;Procedures;Process;Protocols documentation;Qualifying;Quality Control;repository;Research;Research Personnel;Resolution;Resources;Rest;Scanning;Schedule;senior faculty;Specimen;tau Proteins;tau-1;Thick;Training and Education;training opportunity;Universities;white matter;Work

PROJECT_TITLE: Core F: Biomarker Core


PI_NAMEs: WORLEY, PAUL F (contact)

PROJECT_TERMS: accurate diagnosis;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Animal Model;Appointment;Basic Science;biomarker development;Biometry;Brain;Capsicum;career;Clinical;Clinical Research;Clinical Trials;Collaborations;collaborative environment;Communities;Credentialing;Development;Disease;Early Diagnosis;Education;education research;Educational Activities;Encapsulated;Ensure;Environment;Ethics;experience;Exposure to;Faculty;Financial Support;Fostering;Funding;Goals;Grant;improved;Individual;innovation;Institution;interest;Intervention;Knowledge;Leadership;medical schools;meetings;Mentors;Mentorship;Methodology;Minority;multidisciplinary;neurobiological mechanism;Neurodegenerative Disorders;Neurology;Neurosciences;next generation;Parkinson Disease;Pathologic;Pathology;Persons;Phase;Play;Postdoctoral Fellow;programs;Psychiatry;Research;Research Infrastructure;Research Personnel;Resources;Risk Reduction;Role;Science;Scientific Advances and Accomplishments;senior faculty;skills;Students;success;symposium;Talents;Teacher Professional Development;Time;Training;training opportunity;Training Programs;Training Support;Translational Research;Universities;Visit;Wages;Work

PROJECT_TITLE: Research Education Component


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Current approaches to treat glioblastoma, an aggressive brain cancer, have been unsuccessful due to its ability to adapt and evolve. This is possible because the environment within the tumor presents signals that help glioblastoma cells evade therapies and continue to grow. Understanding how these signals in the tumor environment change due to treatments may help researchers identify new drugs and approaches that can target both the tumor environment and the tumor cells that benefit from it.

PI_NAMEs: CHEN, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Ankyrins;Atomic Force Microscopy;Binding Sites;biophysical model;Biophysical Process;biophysical properties;biophysical tools;Biophysics;Caring;CD44 gene;Cells;chemotherapy;combat;Complex;Cues;Development;Digestion;Disease;effective therapy;Electron Microscopy;Environment;ERM protein;Evolution;Extracellular Matrix;gain of function;Genes;Glioblastoma;Goals;HAS2 gene;Histological Techniques;Human;Hyaluronan;Hyaluronic Acid;Hyaluronic Acid Binding;Hyaluronidase;Hydrogels;improved;In Vitro;in vivo;insight;Investigation;Link;loss of function;LOX gene;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;Mass Spectrum Analysis;Mechanics;mechanotransduction;Mesenchymal;Mesenchymal Cell Neoplasm;migration;Molecular Profiling;Molecular Weight;mutant;Nature;neoplastic cell;novel;novel strategies;novel therapeutics;Nuclear Translocation;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Primary Brain Neoplasms;Process;Production;profiles in patients;Prognosis;Proliferating;promoter;Property;Radiation therapy;receptor;Reporting;Research Personnel;Role;Shapes;Signal Transduction;STAT3 gene;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;Tissues;tumor;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-Associated Process;tumorigenic;Tumorigenicity;Work

PROJECT_TITLE: The Role of HA Remodeling and Mesenchymal Transitions in Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MIDDLEBURY

ORG_DEPT: CHEMISTRY

ORG_NAME: MIDDLEBURY COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE: Larger structural variants (SVs) underlie a variety of genetic diseases, however accurately detecting SVs with widely used short read sequencing technologies remains challenging. As a result, there is a substantial gap between our understanding of the role of single-nucleotide DNA changes and SVs. This project will develop more accurate approaches for identifying true SVs to expand our knowledge of human genetic variation and to improve our understanding and diagnosis of genetic disease.

PI_NAMEs: LINDERMAN, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Alleles;analysis pipeline;cloud based;cohort;college;Complex;Data;Data Set;deep learning;deep neural network;detection method;Disease;DNA;Environment;Exclusion;Future;Genetic Diseases;genetic disorder diagnosis;Genetic Variation;Genome;genome sequencing;Genomics;Genotype;Goals;Haplotypes;Human;Human Genetics;Human Genome;human pangenome;Image;imaging approach;improved;instrument;Knowledge;Learning;Length;Machine Learning;Manuals;Methods;model generalizability;Modeling;Molecular Diagnosis;novel;novel strategies;Nucleotides;Pathogenesis;Performance;Play;Population;Population Heterogeneity;Process;prototype;Repetitive Sequence;Research;Research Personnel;Resources;Role;Sampling;simulation;Single Nucleotide Polymorphism;Software Tools;Source;structural imaging;Techniques;Technology;telomere;Testing;tool;Training;training data;undergraduate student;Variant;variant detection;Visual;Work

PROJECT_TITLE: Deep learning methods for genotyping structural variants in human genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (80)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric

ORG_CITY: FORT WORTH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS CHRISTIAN UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because emotion dysregulation contributes to the development of most mental health disorders and the investigation of emotion regulation is a public health priority. Autism spectrum disorder impacts as many as 1 in 44 children in the USA -- the majority of which have a co-occurring mental health disorder—and this study will contribute critical knowledge that can be used to reduce mental health disorders in children on the autism spectrum. Thus, the proposed research is relevant to NIH’s stated priorities to understand emotional development among children on the autism spectrum.

PI_NAMEs: EKAS, NAOMI VANESSA (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Academic Research Enhancement Awards;Anger;Autism diagnostic;autism spectrum disorder;autism symptoms;autistic children;Behavioral;career;Characteristics;Child;Child Development;Child Rearing;Climate;comparison group;contextual factors;Data;design;Development;emotion dysregulation;emotion regulation;Emotional;Emotions;Environment;experience;Family;Fathers;Fright;Geographic Locations;Goals;Happiness;Health;Heterogeneity;innovation;Intervention;Investigation;Knowledge;Language;Longitudinal Studies;Measures;mental development;Mental disorders;Mental Health;Methods;Modeling;Mothers;National Institute of Child Health and Human Development;Outcome;Parents;Pathway interactions;Physiological;premature;prevent;Process;Public Health;public health priorities;Publishing;Reaction;recruit;Reporting;Research;Research Activity;Risk;Risk Factors;Role;Sampling;Severities;skills;Specific qualifier value;Students;Survey Methodology;Testing;Texas;theories;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Role of Family Contextual Factors in the Development of Emotion Regulation in Young Children on the Autism Spectrum

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

PHR: PROJECT NARRATIVE Photoinduced cleavage of chemical bonds is an efficient and noninvasive way for selective release and delivery of biochemically relevant compounds in vivo towards chemotherapeutic and diagnostic applications. Near- infrared (NIR) light is benign and penetrates deeper into tissues, which presents an efficient way to realize these goals. Towards this goal the proposed research will establish a new design of platinum-based framework toward NIR-uncaging of bioactive molecules.

PI_NAMEs: ZHENG, YAORONG  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;anti-cancer;Benign;Biochemical;Bioinorganic Chemistry;Biological;Biology;Biomedical Research;Carboplatin;Cellular biology;chemical bond;chemical cleavage;Chemicals;Chemistry;Cisplatin;Complex;Complication;Copper;Darkness;Data;Dedications;design;Development;Diagnostic;Doxorubicin;Drug Delivery Systems;Drug Kinetics;Dyes;Education;effectiveness evaluation;efficacy validation;Electron Transport;empowerment;Environment;Exhibits;extracellular;flexibility;fluorophore;functional group;Goals;graduate student;Hypoxia;In Vitro;in vivo;innovation;insight;Interdisciplinary Study;invention;irradiation;Ligands;Light;lipophilicity;Location;luciferin;metal complex;Methods;Modeling;near infrared dye;novel;novel strategies;Oxygen;Penetration;Pharmaceutical Preparations;Photobleaching;Phototherapy;Phototoxicity;Platinum;prevent;Process;programs;Property;recruit;Reducing Agents;Reporter;Reporting;Research;Research Project Grants;scaffold;spatiotemporal;success;Techniques;Technology;technology validation;Testing;Therapeutic;Tissues;Training;tumor;tumor xenograft;Ultraviolet Rays;undergraduate research;undergraduate student;Universities

PROJECT_TITLE: Light-Controlled Supramolecular Platinum Complexes for Biomedical Applications

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Rehabilitation;Rural Health;Stroke;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE/RELEVANCE The New England Regional Coordinating Center of the NINDS Stroke Net Network will continue to include 11 New England hospitals with nationally and internationally recognized patient care and clinical research programs: Baystate Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham & Women's Hospital, Lahey Hospital, Massachusetts General Hospital, Spaulding Rehabilitation Hospital Network, Tufts Medical Center, University of Massachusetts Memorial Medical Center and University of Vermont Medical Center. In the next cycle, we will seek to add Dartmouth Hitchcock Medical Center to increase our access to rural populations.

PI_NAMEs: SINGHAL, ANEESH B (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Achievement;Acute;acute care;Adult;Advocacy;American Heart Association;Area;Blood Vessels;Boston;Caring;Child;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Network;Collaborations;Community Hospitals;Complement;data quality;design;Discipline;early phase clinical trial;early phase trial;Educational Activities;Emergency Medicine;Enrollment;Environment;experience;Faculty;Funding;Future;General Hospitals;Geography;Goals;Health;Hospitals;improved;improved outcome;Infrastructure;innovation;Inpatients;Institution;International;Investigation;Israel;Lead;Leadership;Letters;Massachusetts;Medical;Medical center;medical specialties;member;metropolitan;Mission;Multicenter Trials;multidisciplinary;National Institute of Neurological Disorders and Stroke;network models;neuroimaging;Neurologic;Neurologist;Neurology;neurosurgery;New England;New Hampshire;next generation;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Pediatrics;Performance;Phase;phase III trial;Population Heterogeneity;Populations at Risk;Positioning Attribute;pre-clinical;Principal Investigator;programs;Protocols documentation;Public Health;Recording of previous events;Records;Recovery;recruit;Recurrence;Rehabilitation therapy;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;research study;Resources;Role;Rural Hospitals;Rural Population;Science;Seasons;Site;skills;Stroke;stroke neurology;Stroke prevention;stroke recovery;stroke rehabilitation;stroke risk;stroke trials;suburb;success;Talents;Teaching Hospitals;telerehabilitation;telestroke;Testing;Training;Training and Infrastructure;Translating;Translational Research;translational therapeutics;trial enrollment;United States National Institutes of Health;Universities;Vermont;Vision;Woman

PROJECT_TITLE: New England Regional Coordinating Center for the NINDS Stroke Trials Network (StrokeNet)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ADMINISTERING_IC: EB

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: ROCHESTER

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: NARRATIVEK Image-Guided Surgery reduces the di!culty of laparoscopic surgery by localizing surgical instruments in real time. This project will grant IGS the ability to update reference images in real-time during surgery, providing a clear view of the surgical process and improving the accuracy, completeness, and e!ciency of laparoscopic surgeries.

PI_NAMEs: LEE, YANGMING  (contact)

PROJECT_TERMS: Address;Algorithms;Anatomy;Area;Blood Vessels;bone;Clinical;Clinical Data;Collaborations;Compensation;Complement;computer scientist;Computer software;Data;deep learning;Dependence;design;Detection;Endoscopes;Endoscopy;Ensure;Environment;Equipment;Excision;experience;Grant;Graph;Human;Image;Image-Guided Surgery;improved;instrument;Intention;Knowledge;Label;Laparoscopic Surgical Procedures;Learning;Magnetic Resonance Imaging;Manufacturer;Medical;Memory;Methods;Modeling;Modernization;Modification;Motion;Nerve;Non-linear Models;novel;Operating Rooms;operation;Operative Surgical Procedures;Pathology;patient safety;Patients;Pattern;Procedures;Process;reconstruction;Research;Sampling;Scientist;Second Look Surgery;Shapes;Sinus;skull base;soft tissue;Structure;success;Surgeon;Surgical Instruments;System;Techniques;Technology;Time;Tissues;Training;training data;Update;usability;Validation;visual tracking;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Improving Image-Guided Surgery Precision and Reliability with Real-time Modification Tracking in Endoscopic Sinus and Skull Base Surgery

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Skin Cancer

ORG_CITY: Auburn

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Despite advances in treating many cancers, metastatic skin cutaneous melanomas that harbor a wild-type BRAF gene (“wild-type BRAF melanomas) remain very difficult to treat. Here we test the hypothesis that ERBB4 gain-of-function mutant proteins interact with the EGF receptor or HER2/Neu receptor to stimulate the PI3K pathway, which cooperates with the mutations in the RAS or NF1 genes to drive the proliferation of wild-type BRAF melanomas. Thus, we predict that the successful completion of the proposed research will lead to sorely needed improvements in treating a very aggressive cancer.

PI_NAMEs: RIESE, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;Affect;Alleles;Biological Models;BRAF gene;Cell Line;Characteristics;Coupling;Cutaneous Melanoma;Data;density;Development;Epidermal Growth Factor Receptor;erbB-2 Receptor;ERBB2 gene;ErbB4 gene;Exhibits;experimental study;gain of function;Gene Expression;Gene Mutation;Genetic Transcription;Goals;Heterodimerization;Immune checkpoint inhibitor;improved;inhibitor;Knowledge;Ligands;Malignant Neoplasms;MEKs;Melanoma;Melanoma Cell;Mus;mutant;Mutation;NF1 gene;Outcome;outcome prediction;Outcome Study;Pathway interactions;Patient Care;Phosphatidylinositide 3-Kinase Inhibitor;PIK3CG gene;Proliferating;Proteins;Publishing;RAS genes;Research;Signal Transduction;Skin;Skin Cancer;Testing;Therapeutic Intervention;tumor;Tumorigenicity;Tyrosine Phosphorylation;Xenograft Model

PROJECT_TITLE: Is ERBB4 a Driver of BRAF WT Melanomas?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (81)]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Sarcopenia;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: PROJECT NARRATIVE In men with prostate cancer undergoing hormonal treatment (known as “ADT”), loss of muscle mass and function—“sarcopenia”— is one of the most prevalent and debilitating symptoms with a profound negative effect on quality of life, and without any known effective treatment. To set the foundation for the development of these much-needed treatments in the future, we are proposing a clinical trial where men with prostate cancer starting ADT will be followed for one year with the goals of establishing how best to measure and predict sarcopenia, as well as delineating skeletal muscle mechanisms leading to this complication, including the role of the mitochondria. The data generated will provide essential information on tools to measure sarcopenia that are clinically meaningful to patients, shed light on new biological targets for this condition, and identify markers of sarcopenia that can lead to early diagnosis and guide the selection of patients and outcomes for future clinical trials.

PI_NAMEs: GARCIA, JOSE M. (contact);GHARIB, SINA A

PROGRAM_OFFICER_NAME: GOOD, MARGE

PROJECT_TERMS: advanced prostate cancer;Agreement;androgen deprivation therapy;Biogenesis;Biological;Biological Markers;biomarker identification;Biopsy;Blood specimen;Body Composition;cancer diagnosis;Cancer Etiology;Cancer Patient;Cessation of life;Clinical;Clinical Trials;clinically relevant;Complication;Data;debilitating symptom;Development;Diagnosis;Disease;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;effective therapy;European Organization for Research and Treatment of Cancer;experience;falls;Fatigue;Foundations;Future;Gait speed;Gene Expression;Genes;Goals;health related quality of life;Hormonal;Immune response;Impairment;interest;Interview;Knowledge;lean body mass;Lived experience;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;Metastatic Prostate Cancer;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Profiling;mortality;multiple omics;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;Nature;novel;Outcome;Outcome Measure;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Selection;Patients;Pharmacological Treatment;Phenotype;Physical Function;Physical Performance;Plasma;Population;predictive marker;Predictive Value;Production;Prostate Cancer therapy;Proteins;Quality of life;Questionnaires;Reactive Oxygen Species;recruit;reduced muscle strength;Reporting;Respiration;Role;sarcopenia;Skeletal Muscle;specific biomarkers;standard care;Structure;Symptom Burden;therapy development;Time;tool;Transcript;United States

PROJECT_TITLE: SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT)

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative  Drug resistant cancer is virtually incurable, yet how cancer cells acquire resistance remains unknown. This is, in part, because the events that lead to resistance occur at low frequencies and at unpredictable times making it difficult to observe with conventional approaches. Here I propose the use of new technologies that enable continued monitoring of individual cells to pave the way towards treatment strategies that minimize the risk of acquired resistance.

PI_NAMEs: REGOT, SERGI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: acquired drug resistance;Aneuploidy;Automobile Driving;Biochemical;Biosensor;Breast Cancer Cell;Bypass;cancer cell;CDK4 gene;Cell Cycle;Cell Cycle Arrest;Cell Therapy;cell type;Cells;Cellular Stress;chemotherapy;Chromosomal Instability;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cyclin-Dependent Kinase Inhibitor 2A;Data;Diploidy;DNA Damage;Drug resistance;Epigenetic Process;Event;Evolution;Frequencies;Genetic;Genome;genome editing;genomic data;Goals;Healthcare;Human;Image;Image Analysis;imaging approach;Individual;Inflammatory;insight;Lead;live cell imaging;Mainstreaming;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mitosis;Mitotic;Modeling;Molecular;Monitor;Mutation;new technology;novel;Oncogenes;Oncogenic;Organoids;Osmosis;Paracrine Communication;patient derived xenograft model;physiologic stressor;Physiological;Ploidies;Population;Process;Prognosis;Proliferating;Property;Recording of previous events;refractory cancer;Resistance;Resistance development;response;Ribosomes;risk minimization;Role;S phase;Signal Transduction;single cell analysis;single cell sequencing;Stress;Survival Rate;Techniques;Testing;Therapeutic;Time;Tissues;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor progression;tumorigenesis;virtual;whole genome;Work

PROJECT_TITLE: Causes and Consequences of Whole Genome Duplication in Cancer Progression and Acquired Drug Resistance

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The University of Iowa (UI) Regional Stroke Research Network aims to continue to maximize efficiencies in developing, promoting, and conducting high quality multi-site clinical trials on stroke prevention, treatment, and recovery that reaches underserved rural patients who are unable to participate in stroke trials.

PI_NAMEs: LEIRA, ENRIQUE CARLOS (contact)

PROJECT_TERMS: acute stroke;Address;adjudication;Air;American;Assessment tool;Award;Caring;cerebrovascular;Cerebrovascular Disorders;Classification;Clinical;Clinical Trials;college;Community Hospitals;Conduct Clinical Trials;County;Dedications;Development;Disparity;effective intervention;endovascular thrombectomy;Enrollment;Ethics;Exclusion;experience;Funding;geographic barrier;Geographic Locations;Geography;Goals;Grant;Hospitals;improved;industry partner;Informed Consent;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Iowa;Iowan;Leadership;Link;Medical;Medicine;member;Methodology;Midwestern United States;Mission;Modernization;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Neurological Disorders and Stroke;Native American population;Native Americans;next generation;novel;Outcome;pandemic disease;Participant;participant enrollment;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Phase;Positioning Attribute;pre-clinical assessment;preclinical study;Productivity;Protocols documentation;Recovery;recruit;Research;Research Infrastructure;Research Personnel;residence;Resources;Rural;rural patients;rural underserved;Site;Stroke;stroke intervention;Stroke prevention;stroke therapy;stroke trials;StrokeNet trials;success;Supplementation;Testing;therapy development;Training;trial readiness;Trust;United States National Institutes of Health;Universities;Uric Acid;working group

PROJECT_TITLE: The University of Iowa's Regional Stroke Research Network


NIH_SPENDING_CATS: Cancer;Urologic Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Platinum-based chemotherapy is the preferred first-line therapy for advanced bladder cancer; however, resistance is common and lethal. We hypothesize that interactions among tumor and immune cell states drive platinum chemotherapy resistance and progression in bladder cancer. We will use hypothesis-driven mechanistic, computational, and patient-centered strategies to dissect how cell states and interactions promote disease progression in bladder cancer.

PI_NAMEs: MOUW, KENT W;VAN ALLEN, ELIEZER M (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: American;Biological Assay;Biological Models;cancer diagnosis;Cancer Model;Carboplatin;Cell Communication;Cell Cycle;Cell Physiology;Cells;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;cohort;Companions;Computational algorithm;Computing Methodologies;Data;Development;Disease;Disease Progression;DNA Repair;DNA Repair Pathway;ERCC2 gene;Evolution;experimental study;FBXW7 gene;GDF15 gene;genome-wide;Genomics;Immune;improved;In Vitro;in vivo;Induced Mutation;insight;jun Oncogene;Ligands;Link;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Analysis;Motivation;Muscle;Mutation;Myeloid Cells;neoplastic cell;novel;novel therapeutics;patient oriented;patient population;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Platinum;Population;pre-clinical;Pre-Clinical Model;Process;programs;Property;receptor;Residual state;Resistance;resistance mechanism;Role;Solid Neoplasm;TGFBR2 gene;Therapeutic;therapy resistant;transcriptional reprogramming;treatment response;tumor;Tumor Promotion;Tumor-associated macrophages;Tumor-infiltrating immune cells;whole genome;Work

PROJECT_TITLE: Dissecting Integrated Cellular Programs Promoting Platinum Resistance and Progression in Bladder Cancer


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Rural Health;Stroke

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Stroke is a leading cause of a preventable disability and death. The StrokeNet Research Network provides critical infrastructure for the efficient conduct of definitive multicenter stroke trials necessary to improve stroke prevention, intervention, and recovery. The Upper Midwest Regional Coordinating Center will continue to advance the StrokeNet mission through exceptional clinical trial recruitment, individualized mentorship of early career investigators and trainees, and sustained commitment to local investigator-initiated research.

PI_NAMEs: LAKSHMINARAYAN, KAMAKSHI ;STREIB, CHRISTOPHER  (contact)

PROJECT_TERMS: Acceleration;acute stroke;Adoption;Automobile Driving;care systems;career;Catchment Area;Cellular Phone;cerebrovascular;Cessation of life;Clinical;clinical care;clinical practice;Clinical Research;clinical trial enrollment;clinical trial recruitment;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;Complex;Computerized Medical Record;Conduct Clinical Trials;Consent;COVID-19;Dedications;design;Development;disability;Electronics;Emergency Care;Enrollment;Ensure;Equity;experience;Faculty;Federally Qualified Health Center;Fellowship;Funding;Future;Grant;Health;Health Insurance Portability and Accountability Act;Health Resources;Health system;Hospitals;improved;Industry;Informed Consent;Infrastructure;innovation;Institution;Intervention;Investigator-Initiated Research;Leadership;lectures;Location;meetings;Mentors;Mentorship;Midwestern United States;Minnesota;Mission;Modernization;Multi-Institutional Clinical Trial;next generation;novel;operation;participant enrollment;patient population;Performance;Persons;physician-scientist training program;Physicians;programs;Protocols documentation;Public Health Schools;Qualifying;Recovery;recruit;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;Rural;Scientist;Site;Standardization;Stroke;Stroke prevention;stroke recovery;stroke therapy;stroke trials;StrokeNet clinical trials;success;symposium;Talents;Telemedicine;Time;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;University resources;working group

PROJECT_TITLE: Upper Midwest StrokeNet Regional Coordinating Center (RCC)


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative As a consequence of Electronic Health Record (EHR) adoption there has been rapid and widespread growth in the use of documentation assistants such speech recognition and medical scribes to untether providers from the EHR by facilitating documentation, data gathering and data retrieval for providers. With the COVID-19 pandemic and the rapid adoption of telemedicine, these issues have been magnified spurring the evolution of 2 new forms of documentation assistance, virtual scribes and digital scribes, yet little data exists on their impact and efficacy and no data directly compares and contrasts all 4 of these forms of documentation assistance to aid health systems in selection and monitoring of these solutions. The goal of this proposal is to use a comprehensive, mixed-methods approach, including high-fidelity simulation, to establish a success matrix and means of monitoring to aid organizations in the selection, and impact evaluation of these 4 modalities of documentation assistance across ambulatory care environments.

PI_NAMEs: MOHAN, VISHNU  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Adopted;Adoption;Ambulatory Care;Artificial Intelligence;artificial intelligence algorithm;Back;burnout;Caring;Communication;Computer software;COVID-19 pandemic;dashboard;Data;Data Storage and Retrieval;Decision Making;Development;digital;direct patient care;Disparate;Documentation;Educational Curriculum;efficacy evaluation;Electronic Health Record;electronic health record system;Elements;Environment;Epidemic;Ethnography;Evaluation;Evolution;Goals;Growth;Guidelines;Hand;head-to-head comparison;Health;Health system;Hour;Human;Impact evaluation;improved;innovation;Length;Location;Measures;Medical;Medical Records;medical specialties;member;Methodology;Methods;Modality;Modification;Monitor;multidisciplinary;Natural Language Processing;Outcome;Output;pandemic disease;pandemic potential;patient-clinician communication;Patients;Persons;Physicians;Play;pre-pandemic;Process Assessment;Protocols documentation;Provider;Resources;Role;Safety;Series;simulation;speech recognition;Standardization;success;System;Techniques;Telemedicine;Time;Training;trend;usability;virtual;virtual assessment;Visit;Voice;Work

PROJECT_TITLE: Evaluation of Impact of EHR Documentation Assistant Modalities on Provider and System Level Outcomes

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Leveraging decades of NCI investments in clinical trials, data infrastructure, and cancer screening research, the I-SCREEN (Improving Strategies for Cancer Reduction through Early-detection and ENgagement) CSRN ACCESS Hub consists of an NCI-designated Cancer Center, two integrated care delivery systems, one federally qualified health system, and one rural critical access hospital system. I-SCREEN will recruit some of the most under-represented populations in clinical trials, including Hispanics, Native Hawaiian/Pacific Islanders, Asian subgroups, and rural populations. Our goal is to reduce cancer-related mortality by rapidly investigating emerging, novel screening technologies in diverse study cohorts to ensure that efficacious new technologies have broad reach to decrease, and not widen, cancer-related health disparities.

PI_NAMEs: COOK, LINDA S (contact);HONDA, STACEY ;RITZWOLLER, DEBRA P

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Address;Asian;biobank;Biological Specimen Banks;Blood;Cancer Center;Cancer Control;cancer health disparity;Cancer Research Network;cancer type;care delivery;Catchment Area;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Collection;Colorado;Colorectal;colorectal cancer screening;Communication;Communities;Community Clinical Oncology Program;critical access hospital;Data;data infrastructure;data repository;data resource;Data Set;design;Development;disparity reduction;Early Diagnosis;Ecosystem;Enrollment;Ensure;experience;Feasibility Studies;follow-up;Funding;Geographic Locations;Goals;Hawaii;Health system;Hispanic;Hispanic Populations;implementation science;improved;Infrastructure;integrated care;Investments;Lung;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;member;metropolitan;Modeling;mortality;multimodality;Native Hawaiian;NCI-Designated Cancer Center;new technology;novel;oncology program;Outcome;Ovarian;Pacific Islander;patient engagement;Patients;Population;Population Research;Positioning Attribute;Prevention;Procedures;Process;Prostate;Qualifying;recruit;Research;Research Personnel;Resources;Rest;Rural;rural area;Rural Health Centers;rural health network;Rural Population;screening;Screening for cancer;screening program;Site;Subgroup;synergism;System;Technology;Testing;The University of Colorado Cancer Center;Time;Translational Research;trial design;Underrepresented Populations;United States;Universities

PROJECT_TITLE: Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O1)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: Project Narrative Chronic Ankle Instability is a common debilitating condition that negatively affects patient function and quality of life. Chronic ankle instability is often thought of as a single pathology across patients, however, several subgroups exist, and their underlying features are not well understood. Therefore, we seek to understand the underlying functional and neurophysiological characteristics of different chronic ankle instability sub-groups.

PI_NAMEs: ROSEN, ADAM B (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Aging;Ankle;Ankle Injuries;balance testing;Balance training;Brain imaging;Central Nervous System;Characteristics;Chronic;Clinical;Cognitive;Decision Making;Development;disability;Equilibrium;Equipment;Esthesia;Evaluation;evidence base;experience;functional near infrared spectroscopy;Health;health related quality of life;Imaging technology;improved;Individual;Injury;life span;Limb structure;Lower Extremity;Masks;Measurable;Measurement;Measures;Mechanics;Methods;motor control;Movement;Muscle;Nature;Nervous System Physiology;Neurocognitive;Neurologic;neurophysiology;novel;Orthopedics;Participant;Pathology;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;performance tests;Perfusion;Physical activity;Physical Function;physical impairment;Population;portability;Protocols documentation;Quality of life;Reaction;Recovery;Recurrence;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;response;Series;Side;soft tissue;Sprain;Stress;Structure;Subgroup;Technology;Testing;Time;Traumatic Arthropathy;Work

PROJECT_TITLE: Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SMEP-C (80)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: BOSTON

PHR: Project Narrative Despite the successful development of multiple immunotherapeutic modalities, tumor immune exclusion mechanisms prevent many patients from reaping their benefits. Recent models suggest that tumors actively enforce a mechanical barrier at the tumor-stroma periphery to exclude antitumor immune infiltration and to prevent subsequent immune-mediated killing. This proposal seeks to systematically dissect the components of the tumor-immune mechanical barrier through approaches including in vivo preclinical mouse models, genetic screening, and multi-omics spatial analysis of patient specimens, which will reveal unanticipated immune suppressive mechanisms utilized by cancer and thereby shed new light on novel anticancer treatment strategies.

PI_NAMEs: WU, BOGANG  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adoptive Cell Transfers;anti-cancer therapeutic;anti-cancer treatment;anti-PD-1;Antibodies;Antibody-drug conjugates;Area;Award;Biochemistry;Bioinformatics;Biological Assay;Cancer Biology;cancer type;Carcinoma;career;career development;cell type;Cells;Clinical;Clinical Trials;cohort;CRISPR screen;cytotoxic;Data;Development;epigenomic profiling;Exclusion;Exhibits;exome sequencing;experimental study;Extracellular Matrix;FDA approved;Future;General Hospitals;Genetic Complementation Test;Genetic Screening;Goals;Growth;Image;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;Immunocompromised Host;Immunodeficient Mouse;immunogenic;immunogenic cell death;Immunologic Markers;Immunologic Surveillance;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo;inhibitor;innovation;Innovative Therapy;Institution;Intercellular Junctions;Knowledge;Libraries;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Massachusetts;Mechanics;Mediating;medical schools;Mentors;metabolomics;Modality;Modeling;mouse model;multiple omics;Mus;mutant;neoplastic cell;novel;Nude Mice;Organ;overexpression;paralogous gene;Pathway interactions;Patient-Focused Outcomes;Patients;pembrolizumab;Pharmaceutical Preparations;Phase;Phenotype;pre-clinical;Precision therapeutics;prevent;Proteins;Proteomics;rational design;reconstitution;Research;Research Personnel;Resistance;Resources;response;Shapes;skill acquisition;Specimen;synergism;Techniques;Testing;therapy design;Tight Junctions;Topoisomerase;Training;transcriptome sequencing;transcriptomics;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Volume;tumor-immune system interactions;Tumor-infiltrating immune cells;Vaccination;Work

PROJECT_TITLE: Breaching the Tumor-Immune Mechanical Barrier for Optimal Antitumor Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Genetics;Hematology

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Identifying genomic mutations controlling the susceptibility to developing blood clots (thrombosis) is important for managing this disease. We have identified a mutation in the Arl6ip5 gene that has a major impact on reducing thrombosis in a mouse model of lethal thrombosis. The goal of this project is to use mouse genetics, assays assessing blood coagulation and platelet function, and molecular genomics techniques to determine the mechanisms by which Arl6ip5 deficiency reduces thrombosis.

PI_NAMEs: WESTRICK, RANDAL J (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Activated Partial Thromboplastin Time measurement;ADP-Ribosylation Factors;Affect;Agonist;Biological Assay;Biological Sciences;Blood;Blood coagulation;Blood Coagulation Factor;Blood Platelets;Cardiovascular system;career;Cell Physiology;Cells;Coagulation Process;Complex;Cytoskeleton;Defect;Disease Management;Dominant Genetic Conditions;dominant genetic mutation;Ensure;Environment;Ethylnitrosourea;Event;Exhibits;experimental study;Factor VIII;Female;follow-up;Frequencies;Funding;Gene Expression;Gene Mutation;Gene Proteins;Genes;Genetic;Genetic Transcription;genetic variant;genome editing;genome-wide;Genomics;Genotype;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Hemorrhage;Hemostatic Agents;Hemostatic function;Heterozygote;Homozygote;in vivo;insight;Kinetics;Knowledge;Liver;loss of function;loss of function mutation;male;Measurement;Microfilaments;Mission;Molecular;Molecular Genetics;mouse genetics;mouse model;Mus;Mutagenesis;mutant;Mutate;Mutation;mutation screening;Myocardial Infarction;next generation;novel;Occupations;Partner in relationship;Pathway interactions;Penetrance;Perinatal mortality demographics;Persons;Phenotype;Phosphatidylserines;Plasma;Plasma Proteins;Platelet Activation;Platelet aggregation;Platelet Aggregation Induction;platelet function;Play;post-doctoral training;Predisposition;Process;Proteins;Regulation;Research;Research Personnel;Role;Rose Bengal;Scientist;Stroke;Suppressor Mutations;Susceptibility Gene;Tail;Techniques;Testing;TFPI;Therapeutic;Thrombosis;thrombotic;Thrombus;Time;Training;Training Programs;transcriptome sequencing;Translations;United States National Institutes of Health;Universities;Variant;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: Investigating the functional roles of Arl6ip5 in suppressing thrombosis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: QUEENS

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: PROJECT NARRATIVE This proposal focuses on the role of p53-mediated Interleukin 17 Receptor B (IL17RB) repression in tumor suppression and inflammation inhibition. IL17RB, a cytokine receptor involved in inflammation, has been found to be overexpressed in various cancers through the activation of multiple cancer-prone signaling pathways. p53, one of the major cellular barriers against cancer, has been demonstrated to regulate innate and adaptive immune responses. Understanding the mechanisms of how IL17RB links p53’s crosstalk with other signaling pathways and how p53 attenuates oncogenic effects of chronic inflammation through repressing IL17RB will lead to the development of novel anti-cancer strategies and inflammation inhibitors.

PI_NAMEs: ZHU, YAN  (contact)

PROJECT_TERMS: adaptive immune response;anti-cancer;Apoptosis;Attenuated;attenuation;Biochemical;Biological Response Modifiers;Biomedical Research;cancer cell;career;Cell Cycle Arrest;Cell Death;Cells;Chronic;Coculture Techniques;Colon Carcinoma;cytokine;Cytokine Receptors;Data;Data Set;Development;Dimethyl Sulfoxide;Disease;DNA Repair;Environment;Family;functional loss;Future;Gene Expression Profiling;Genes;Goals;graduate student;HCT116 Cells;human disease;IL17 gene;IL8 gene;Immune;Immune response;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;Interleukin Activation;Interleukin-1;Investigation;Lead;Learning;Link;Lipopolysaccharides;LNCaP;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;MDM2 gene;Mediating;Metabolism;mRNA Expression;mRNA sequencing;novel;Oncogenic;Osteosarcoma;overexpression;Play;Predisposing Factor;prevent;prostate cancer cell;Proto-Oncogene Proteins c-akt;Quantitative Reverse Transcriptase PCR;Reaction;receptor;Reporting;Repression;Research;response;RNA;Role;Sampling;Signal Pathway;Signal Transduction;System;Testing;Time;TP53 gene;transcription factor;transcriptome sequencing;tumor;tumor progression;Tumor Suppression;tumorigenesis;undergraduate student;Universities;Work

PROJECT_TITLE: ELUCIDATING THE FUNCTION OF P53-MEDIATED IL17RB REPRESSION


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Skin Cancer

ORG_CITY: ROLLA

ORG_NAME: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY

ORG_STATE: MO

PHR: Deep learning diagnostic accuracy for dermoscopic images can exceed that of dermatologists, however it fails to provide sufficient accuracy to serve as a reliable screening tool for in-person and virtual consultations and automatic triage of lesions. To improve diagnostic accuracy for skin lesion images, we propose an enhanced, publicly accessible database of critical skin lesion structures through expert annotation and curation of thousands of images, enabling a new paradigm for the automatic analysis of cancer images and providing a transparent foundation for cancer image processing. This three-year project will provide educational opportunities for undergraduate students in multiple fields of study at Missouri University of Science and Technology and pre-college STEM outreach educational initiatives.

PI_NAMEs: BECEVIC, MIRNA ;GRICHNIK, JAMES M;STANLEY, RONALD J (contact);STOECKER, WILLIAM V

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: Advanced Development;algorithm development;Amelanotic Melanoma;Appointment;Architecture;Archives;Attention;Benign;Binding;Biological Sciences;Biomedical Engineering;Biomedical Research;Budgets;Cancer Detection;cancer imaging;Characteristics;Classification;Collaborations;Collection;college;Computational Technique;Consensus;Consultations;Cyst;Data;Data Science;Data Set;deep learning;deep learning algorithm;Dermatologist;Dermoscopy;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Discrimination;Education;Education and Outreach;Entrepreneurship;feature detection;feature extraction;field study;Foundations;Goals;high school;High School Student;Image;image archival system;image processing;improved;Incidence;International;Knowledge;Lead;Learning;Lesion;Malignant - descriptor;Measures;Melanoma;Mentors;Methods;Milium Cyst;Missouri;multiple datasets;Nevus;Ozarks;Paper;Persons;Physicians;Pigments;programs;Psychological reinforcement;public database;Publications;Radial;recruit;Research;Research Personnel;ROC Curve;Science;screening;Screening for Skin Cancer;Screening procedure;Seborrheic keratosis;Skin;skin lesion;skin organogenesis;Specialist;Statistical Data Interpretation;STEM program;Stream;Structure;Students;Techniques;Technology;Testing;tool;Training;Training and Education;training opportunity;Training Technics;Triage;undergraduate student;Universities;university student;Validation;validation studies;virtual;Visual;web site

PROJECT_TITLE: Skin Lesion Archive and Annotation for Fusion and Earlier Skin Cancer Detection

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: KALAMAZOO

ORG_NAME: WESTERN MICHIGAN UNIVERSITY

PHR: Irreversible vision loss is one of the top ten disabilities worldwide and is responsible for reduced quality of life and a substantial burden on national healthcare systems. Experiments in this study are designed to test the hypothesis that PNU-282987-induced neurogenesis of retinal neurons in adult mice occurs through activation of Müller glia. The results from this study could have serious implications for reversing vision loss due to traumatic injuries, degenerative retinal disease or age-related issues.

PI_NAMEs: LINN, CINDY L (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: acetylcholine receptor agonist;Address;Adult;Affect;Aftercare;age related;Aging;alpha-bungarotoxin receptor;Applications Grants;Binding;Blindness;Bromodeoxyuridine;career;Cell Line;Cells;Cellular Structures;Chick;Computer software;CRISPR/Cas technology;design;Development;disability;Disease;DTR gene;experimental study;Eyedrops;Flow Cytometry;fluorophore;Ganglion Cell Layer;Genes;Glaucoma;graduate student;Healthcare Systems;immunocytochemistry;In Vitro;knockout gene;Literature;Macular degeneration;Mammals;migration;Mitosis;Mitotic;mRNA sequencing;Muller's cell;Mus;Natural regeneration;neurogenesis;Neuroglia;overexpression;Pathway interactions;Photoreceptors;Population;Primary Cell Cultures;Proliferating;Publishing;Quality of life;Rattus;regenerative;Reporter;Research;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;retinal regeneration;Retinitis Pigmentosa;Reverse Transcriptase Polymerase Chain Reaction;Rodent;Science;Signal Pathway;Signaling Molecule;Source;stem cells;Structure of retinal pigment epithelium;Tamoxifen;Technology;Testing;Training;transcriptome;transcriptome sequencing;Transgenic Mice;Traumatic injury;undergraduate student;Vertebrates;Zebrafish

PROJECT_TITLE: Evidence of neurogenesis in an adult mammalian retina initiated by an alpha7 nAChR agonist

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-R (86)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Project Narrative Acinetobacter baumannii is responsible for a wide variety of infections in humans, including those of the lung, skin and soft tissue, bloodstream, and urinary tract. A. baumanii infections have become increasingly common and pose a significant health threat to the VA population. In addition, A. baumannii has been a leading cause of infections in injured military personnel. The inability to treat A. baumannii infections with currently available antibiotics has reached a critical stage and isolates resistant to all available antibiotics have become a reality and are increasing in frequency. New approaches to treat these infections are critically needed. To combat A. baumannii, we have developed a novel vaccine and identified new small molecule antibiotics.

PI_NAMEs: RATHER, PHILIP N. (contact)

PROJECT_TERMS: Acinetobacter baumannii;Address;Agar;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Attenuated;Attenuated Vaccines;Award;Bacteria;Bacterial Pneumonia;beta-Lactam Resistance;beta-Lactamase;Biochemical;Blood Circulation;career;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Collaborations;combat;Communicable Diseases;COVID-19 patient;Development;Educational Status;Engineering;Exhibits;Family;Fostering;Frequencies;Funding;gene product;Genes;Genetic;Genetic Transcription;Goals;Gram-Negative Bacteria;Health;Healthcare;Hospitals;Human;Immunologics;Inactivated Vaccines;Incidence;Infection;Lactamase;Legal patent;Mediating;Mentors;military injury;Military Personnel;Mus;next generation;normal microbiota;novel;novel strategies;novel therapeutics;novel vaccines;pathogen;Patients;Phenotype;Physiology;Population;post-doctoral training;programs;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resistance;resistant strain;Role;Scientist;Skin Tissue;small molecule;Societies;soft tissue;Structure;Structure of parenchyma of lung;Students;Training;United States National Institutes of Health;Urinary tract;Vaccinated;Vaccines;Ventilator;Virulence;Virulent;Work;World Health Organization

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Tumor evolution is often the cause of outstanding clinical challenges, such as acquired drug resistance and metastasis. Recent work has demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a major driver of tumor evolution but remains difficult to study due to its elusive evolutionary dynamics and substantial variability. This project proposes the development of innovative new computational tools that will illuminate ecDNA heterogeneity and evolution at unparalleled resolution, which will in turn be used to nominate new therapeutic strategies that target ecDNA-mediated tumor evolution.

PI_NAMEs: JONES, MATTHEW GREGORY (contact)

PROJECT_TERMS: Acceleration;acquired drug resistance;Address;Advisory Committees;Algorithms;Automobile Driving;Award;Behavior;Bioinformatics;Biological;Biology;Cancer Biology;cancer cell;Catalogs;Cells;Chromatin;Chromosomal Duplication;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computer software;computerized tools;Computing Methodologies;CRISPR screen;Data;Data Set;Development;DNA amplification;DNA-Protein Interaction;Drug resistance;Drug Targeting;effective therapy;Engineering;Environment;Epigenetic Process;epigenomics;Evolution;Exhibits;extrachromosomal DNA;fitness;Foundations;Future;Gene Expression;Genetic;Genetic study;Goals;Heterogeneity;Immune Evasion;improved;Individual;innovation;insight;intermolecular interaction;Learning;Malignant Neoplasms;Mediating;Mentorship;Methylation;Mitosis;Modeling;Molecular;Molecular Profiling;multiple omics;Mutation;Neoplasm Metastasis;novel therapeutic intervention;Oncogenes;patient stratification;Phase;Population;Process;Proliferating;Property;Recording of previous events;Research;Resolution;response;Science;segregation;single molecule;Solid;spatiotemporal;stem;targeted treatment;Techniques;Technology;Time;tool;Training;training opportunity;training project;treatment strategy;tumor;tumor progression;Universities;Work

PROJECT_TITLE: Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumors


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Rehabilitation;Stroke

ORG_CITY: WASHINGTON

ORG_NAME: CATHOLIC UNIVERSITY OF AMERICA

ORG_STATE: DC

PHR: Project Narrative The goal of this proposal is to understand how different aspects of the robot-assisted training of the hand of chronic stroke survivors can affect their muscle control. First, we will apply two widely-used robot types (end- effector and exoskeleton) to hand movements of stroke survivors, and compare the changes in their muscle use during and after the training with these two devices. We will then examine how two different types of movement feedback (movement amplification or reduction) affect the way stroke survivors control their hand muscles. Finally, we will study if the dynamic condition of the training, i.e., force production or movement, can affect the way they control their hand muscles. The outcome of this study will help us design optimal robotic trainings for the hand of individual stroke survivors, targeting specific problems in their muscle use, which are the very underlying cause of their hand functional impairment. 1

PI_NAMEs: LEE, SANG WOOK  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Adopted;Affect;chronic stroke;Complex;design;Devices;Distal;Dorsal;Exertion;exoskeleton;experience;Extensor;Feedback;Finger joint structure;finger movement;Fingers;Flexor;Freedom;Functional impairment;functional outcomes;Goals;Hand;hand dysfunction;hand rehabilitation;Impairment;improved;Individual;joint mobilization;Joints;Motor;Movement;Muscle;new technology;novel;Outcome;Outcome Study;Output;Pattern;post stroke;Production;Robot;robot assistance;robotic device;robotic training;Robotics;Role;Sensory;sensory feedback;Stroke;stroke survivor;Technology;Therapeutic;Training;virtual reality;virtual reality environment

PROJECT_TITLE: Impact of altered sensorimotor experience in robotic training on adaptation of hand muscle coordination of stroke survivors


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Measures of purifying selection from large reference populations are critical tools for prioritizing variants in diagnostic settings and identifying disease-associated genes. In this project, we will take advantage of access to large and ancestrally diverse genomic datasets, advances in protein structure predicting algorithms, and functional annotations from proteomics to refine the signals of purifying selection in the human genome and improve our measures of this selective constraint.

PI_NAMEs: SAMOCHA, KAITLIN ELISABETH (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: 3-Dimensional;Biological;Biological Process;Clinic;Clinical;clinical care;cohort;Collaborations;Communities;Data;Data Set;Databases;Diagnostic;Diffuse;Disease;Evaluation;exome;Funding;gene discovery;Gene Frequency;General Population;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genome;genomic data;genomic predictors;genomic variation;Genomics;Goals;Human;Human Genome;improved;Individual;Knowledge;loss of function;Malaria;Measures;member;Methods;Molecular;Mutation;Nature;novel;Pathway interactions;Patients;Pattern;Population;Post-Translational Modification Site;Post-Translational Protein Processing;prediction algorithm;pressure;protein complex;protein protein interaction;protein structure;protein structure prediction;Proteins;Proteomics;Rare Diseases;Research;Risk;Signal Transduction;Structure;Subgroup;Tertiary Protein Structure;tool;Variant;Work

PROJECT_TITLE: Integrating genomic data and protein structures to improve measures of selective constraint

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (O2)]