ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Human Genome;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: LAY SUMMARY: The proposed research has broad relevance to public health as it focuses on improving our understanding of the molecular basis of a shared mechanism of kidney disease progression, i.e., renal hyperfiltration injury. Kidney transplants will be used as a model system to test how hyperfiltration causes kidney damage in humans. We expect the findings to be broadly applicable to common kidney disease states such as diabetes and obesity that are also accompanied by hyperfiltration. Insights from this analysis we be applied to prolong the lifespan of kidney transplants and reduce morbidity and mortality associated with chronic kidney disease.

PI_NAMEs: NAIK, ABHIJIT S (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Allografting;Animal Model;Area;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;Biopsy;Cells;Characteristics;Chronic Kidney Failure;cohort;Core Biopsy;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;differential expression;Disease;Disease Pathway;Disease Progression;EDN1 gene;Enrollment;Epidemic;Etiology;Exposure to;Failure;Filtration;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;glomerular basement membrane;Goals;graft function;Histology;Human;human model;Hydrostatic Pressure;IGF1 gene;Immunohistochemistry;improved;In Situ Hybridization;Infection;Injury;innovation;insight;Insulin-Like Growth-Factor-Binding Proteins;Integrin alpha3beta1;KDR gene;Kidney;kidney allograft;Kidney Diseases;Kidney Transplantation;Knowledge;life span;Ligands;Link;living kidney donor;Measurement;Measures;Mediating;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Nephrons;new therapeutic target;non-invasive monitor;Obesity;Outcome;Overlapping Genes;Pathogenesis;Pima Indian;podocyte;post-transplant;Process;Public Health;receptor;Recurrence;renal damage;Renal glomerular disease;Research;Research Personnel;response;Role;Side;single-cell RNA sequencing;Specificity;Stress;Systems Biology;targeted treatment;Technology;Testing;Time;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Urine;validation studies;Vascular Endothelial Growth Factors

PROJECT_TITLE: Defining the molecular landscape of hyperfiltration-mediated glomerular injury using kidney allografts as a model system

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE (RELEVANCE) Anorexia nervosa is a serious mental illness that typically begins in adolescence; it is defined by weight loss in conjunction with cognitive disturbances about eating and body image. Adult women with anorexia nervosa show differences in self-concept and social interactions, but whether these differences precede or develop during the course of illness is unknown. This exploratory project will evaluate self-concept and social interactions as adolescents with AN engage in treatment, improving our understanding of how social processing is related to symptom expression in this disorder.

PI_NAMEs: MCADAMS, CARRIE JUSTINE (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent patient;adolescent woman;Adult;Adult women;Age;Anorexia Nervosa;Behavior;Behavior assessment;Behavioral;Belief;Binge Eating;Body Image;Body Weight;Body Weight decreased;Brain;brain based;Child;Clinical;Clinical assessments;clinical care;clinical implementation;Clinical Treatment;Cognition;Cognitive;cohort;Complex;Computers;Data;Decision Making;design;Development;Disease;Disease remission;Eating;Eating Behavior;Eating Disorders;Emotional;Enrollment;Environmental Impact;Evaluation;Evidence based treatment;Family member;follow-up;Food;Future;Image;Impaired cognition;Impairment;improved;Individual;Informal Social Control;Knowledge;Maintenance;Measures;Mediating;Medical center;Mental disorders;neural;neural circuit;neurobehavioral;neuroimaging;Neuropsychology;Nutritional;Outcome;Participant;Patient Recruitments;Patients;Pediatric Hospitals;Persons;Philadelphia;Pilot Projects;Predisposition;Process;programs;Psychopathology;Questionnaires;Recovery;Relapse;response;Sampling;Self Assessment;Self Concept;Self Direction;Self-Examination;serial imaging;severe mental illness;Site;social;Social Behavior;Social Controls;Social Environment;Social Interaction;social metrics;Social Perception;Social Processes;Structure;Supervision;sustained recovery;Symptoms;Time;Translational Research;Trust;verbal;virtual;virtual assessment;Weight;Work;young adult

PROJECT_TITLE: Social Processes in Adolescent Anorexia Nervosa

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Treatment with platinum-based drugs, in particular cisplatin, in small cell lung cancer (SCLC) often results in the development of resistance leading to therapeutic failure, but the mechanisms remain unclear. We found that cisplatin activates NFIB-MAST1-PLK1 signals to confer adaptive resistance in ASCL1-high SCLC. In this proposal, we will decipher the role of NFIB-MAST1-PLK1 axis in driving adaptive cisplatin resistance and validate MAST1-PLK1 signaling as a therapeutic target to overcome cisplatin resistant in ASCL1-high SCLC using MAST1 inhibitor lestaurtinib.

PI_NAMEs: JIN, LINGTAO  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Affect;Antineoplastic Agents;ASCL1 gene;Automobile Driving;Binding;Biological Assay;Biological Markers;Cancer cell line;Cancer Patient;Cell Cycle Progression;Chemoresistance;chromatin immunoprecipitation;Cisplatin;Clinical;Clinical Trials;Data;data mining;Databases;Disease Progression;drug repurposing;Drug resistance;Drug Targeting;efficacy evaluation;Failure;Genetic Transcription;improved;In Vitro;in vivo;inhibitor;kinase inhibitor;knock-down;Lead;lung cancer cell;Mass Spectrum Analysis;Mediating;Microtubules;mimetics;Mining;Mitotic;Modeling;Molecular;mRNA Expression;Neoplasm Metastasis;NFIB gene;novel;overexpression;patient derived xenograft model;patient stratification;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Platinum;PLK1 gene;prevent;Primary Neoplasm;promoter;Promoter Regions;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Recovery;recruit;Recurrence;Reporter;Resistance;Resistance development;response;Role;screening;Serine;Signal Pathway;Signal Transduction;Site;small cell lung carcinoma;small hairpin RNA;small molecule;standard care;Testing;Therapeutic;therapeutic target;Toxic effect;TP53 gene;transcription factor;tumor;tumor xenograft;ubiquitin-protein ligase

PROJECT_TITLE: The role of NFIB-MAST1 signaling in mediating adaptive cisplatin resistance in SCLC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative Participating in genetic counseling and testing (GCT) can inform treatment and risk management decisions for women at-risk of hereditary breast and ovarian cancer, but Latina women underuse GCT services. This study will test the efficacy of a culturally targeted narrative video in enhancing GCT uptake and psychosocial outcomes in at-risk Latina women through a RCT. We will conduct an Implementation Focused Process Evaluation to gather implementation outcomes that will ultimately enhance the speed and quality of the translational process.

PI_NAMEs: HURTADO DE MENDOZA CASAUS, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;arm;Attitude;Awareness;behavior prediction;Behavioral Model;BRCA mutations;Cancer Patient;cancer risk;Cancer Survivor;Clinic;Cognition;community clinic;Community Health;Consolidated Framework for Implementation Research;cost;Counseling;Data;design;Disparity;disparity reduction;Education;efficacy evaluation;efficacy study;efficacy testing;Elements;Eligibility Determination;Emotional;Emotions;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Exhibits;Face;Future;General Population;Genetic Counseling;genetic counselor;Genetic Enhancement;genetic predictors;genetic testing;Genomics;Goals;Guidelines;Health education;health literacy;Health system;Healthcare;Healthcare Systems;Hereditary Breast and Ovarian Cancer Syndrome;hereditary risk;High Risk Woman;Hour;Hybrids;implementation outcomes;implementation research;improved;innovation;interest;Intervention;Knowledge;Language;Latina;Latina Population;Latinx population;Linguistics;literacy;Malignant Neoplasms;Minority Groups;minority patient;optimism;Outcome;Participant;preference;primary outcome;process evaluation;psychosocial;psychosocial outcome;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;response;Risk;Risk Management;satisfaction;Schedule;Screening procedure;Self Efficacy;Services;Site;Spanish;Speed;success;Survivors;Telephone;Testing;testing services;testing uptake;tool;Training;Translation Process;Translations;Transportation;underserved minority;uptake;Visual Aid;Woman

PROJECT_TITLE: Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Axon myelination is a critical component for circuit function and overall neuronal health, and loss of myelin can result in sensorimotor and cognitive impairments. This proposal seeks to understand the molecular mechanisms oligodendrocytes use to select axons of distinct classes and coordinate formation of appropriate amounts of myelin. These experiments can gain insight as to whether oligodendrocytes use different mechanisms to myelinate axons of distinct classes and may reveal that myelin sheath protein composition might be unique to axon identity.

PI_NAMEs: CAREY, NATALIE J (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Address;Axon;Cell Adhesion Molecules;Cell Lineage;cell type;Cells;Central Nervous System;Code;Data;Detection;Development;Dominant-Negative Mutation;Electric Capacitance;experimental study;Fire - disasters;Fluorescent in Situ Hybridization;Gene Expression;Gene Proteins;Genes;Genetic;genetic approach;gephyrin;Glutamates;Health;Imaging Device;imaging study;Impaired cognition;In Situ Hybridization;in vivo;in vivo imaging;Individual;insight;Interneurons;loss of function;Mediating;Membrane;Metabolic;Modeling;Molecular;Motor;Myelin;Myelin Sheath;myelination;Nature;neural circuit;Neurons;neurotransmission;Neurotransmitters;oligodendrocyte lineage;Oligodendroglia;Output;Pattern;Phenotype;Play;Positioning Attribute;postsynaptic;presynaptic density protein 95;Process;Property;protein function;Proteins;Recording of previous events;Reporter Genes;RNA;Role;scaffold;Scaffolding Protein;Selection Bias;Signal Transduction;Specificity;Spinal Cord;Synapses;Synaptic Vesicles;Testing;theories;Transgenic Organisms;Translating;vesicular release;Work;Zebrafish

PROJECT_TITLE: Oligodendrocyte Lineage Cell Mechanisms of Axon Selection for Myelination


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The mechanisms by which B cell responses are modulated by serum antibody remain poorly defined. This proposal seeks to (1) gain mechanistic insight into the regulatory role immunoglobulin plays in humoral responses and (2) evaluate the implications of antibody mediated feedback on B cell clonal selection. Completion of this work will provide insight into a mode of regulation of adaptive immunity that is important for improved vaccination design.

PI_NAMEs: BARBULESCU, ALEXANDRU  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ablation;adaptive immunity;Address;adoptive B cell transfer;Adoptive Transfer;Affect;Affinity;Anatomy;Animal Model;Antibodies;Antibody Affinity;Antibody titer measurement;Antigen-Antibody Complex;Antigens;arm;Autoimmune Diseases;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biological Assay;Biological Models;Bone Marrow;career;Cells;Cellular biology;Clone Cells;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Data;design;Diphtheria Toxin;doctoral student;Engineering;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Excision;Faculty;Fc Receptor;Feedback;Genetic Engineering;Goals;Hemagglutinin;Home;Human;human pathogen;Immune response;Immune system;Immunization;Immunoglobulins;Immunologic Memory;Immunologics;improved;in vivo;in vivo Model;Infection;Influenza;Influenza Hemagglutinin;innovation;insight;Institution;Interferometry;Knock-in Mouse;Knowledge;Laboratories;Light;loss of function;Mediating;Mentorship;Microanatomy;Modeling;Monoclonal Antibodies;mouse model;Mouse Strains;Mus;Outcome;Output;pathogen;Patient Care;Physicians;Physiological;Plasma Cells;Play;Population;programs;Reaction;receptor;Regimen;Regulation;Reproducibility;Research;response;Role;Running;Scientist;secondary lymphoid organ;Serum;Signal Transduction;Site;Specificity;Structure of germinal center of lymph node;System;Testing;tool;Toxin;Universities;Vaccination;vaccination strategy;vaccine response;Work;zygote

PROJECT_TITLE: Investigating the Effect of Antibody Mediated Feedback on B Cell Clonal Selection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project narrative. Inflammasome sensing of PAMPs and DAMPs has tremendous implications for the development of several inflammatory diseases such as sepsis. Sepsis still remains a major life-threatening condition despite the decades-long effort to develop specific drugs. By uncovering new mechanisms involved in the regulation of inflammasome sensing of PAMPs, the findings from this study could offer new immunomodulatory targets to mitigate inflammatory diseases including sepsis.

PI_NAMEs: RATHINAM, VIJAY  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Albumins;Antibiotics;Bacteria;Bacterial Infections;Binding;Biochemical;Blood;CASP1 gene;Caspase;CD14 gene;CD47 gene;Cell Death;Cell Fractionation;Cell membrane;Cell surface;cell type;Cell Wall;Cells;Chronic;Circulation;Communicable Diseases;Complement;Complex;Confocal Microscopy;Coupled;Cre-LoxP;CRISPR screen;cytokine;Cytolysis;Cytosol;defined contribution;Detection;Development;Disease;Distant;Electrons;Endosomes;Endothelial Cells;Event;Extracellular Space;extracellular vesicles;Family;Flagellin;Flow Cytometry;Genetic Transcription;Germ Lines;HMGB1 gene;Host Defense;Human;IL18 gene;Image;Immune;Immune response;Immunologic Surveillance;immunoregulation;In Situ;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;insight;Integration Host Factors;Interleukin-1;Interleukin-1 beta;Knowledge;Leaky Gut;Life;Lipids;lipopolysaccharide-binding protein;Literature;Location;Lytic;Mass Spectrum Analysis;Mediating;Membrane;Methods;microbial products;Microscopic;Molecular;Multiprotein Complexes;Mus;Mutant Strains Mice;Myeloid Cells;Nucleic Acids;Outcome;pathogen;Pathway interactions;Pattern;Pattern recognition receptor;Perforation;Pharmaceutical Preparations;Physiology;Play;Proteins;Regulation;response;RNA;Role;Sepsis;Signal Transduction;Structure;TLR4 gene;Toxin;Translational Activation;Uric Acid;VDAC1 gene;Vesicle;virtual;Virus;Work

PROJECT_TITLE: Host-derived extracellular vesicles in inflammatory caspase activation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Disability Research;Heart Disease;Mental Health;Palliative Care;Pediatric;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Patients with adult congenital heart disease are at risk for poor health-related quality of life, impaired psychosocial well-being, and early mortality. Palliative care, and specifically, enhanced resilience, has the potential to improve these patient experiences, yet the optimal ways of addressing the palliative care needs of this population are largely unknown. The goals of this project are to evaluate the relationships between resilience and patient-centered psychosocial outcomes, explore patients’ experiences with resilience, and test the feasibility of a resilience intervention to improve these outcomes, in order to improve the health-related quality of life and long-term clinical care of patients with adult congenital heart disease.

PI_NAMEs: STEINER, JILL MARIE (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adolescent;Adolescent and young adult cancer patients;Adult;Advance Care Planning;Affect;Age;Anxiety;anxiety symptoms;Award;Behavior Therapy;Behavioral Research;Cardiology;career;career development;Caring;Cessation of life;Child;Childhood;Chronic Disease;clinical care;Clinical Trials Design;clinically significant;Cognitive;cognitive disability;comorbidity;Competence;Complex;congenital heart abnormality;coping;depressive symptoms;Development;disability;Disease;Disease Progression;Educational Curriculum;Eligibility Determination;Emotional;end of life;Enrollment;Environment;evidence base;experience;Face;Family;feasibility testing;Future;Goals;Grant;Health;health related quality of life;Healthcare;Heart failure;Hospitalization;Illness impact;Impairment;improved;improved outcome;Individual;Institution;Intervention;Interview;Kidney Diseases;Knowledge;Learning;Link;Liver diseases;Lung Diseases;Manuscripts;Measures;Medical;meetings;Mental Depression;Methods;Minority Participation;mortality;novel;Operative Surgical Procedures;Outcome Measure;Palliative Care;Parents;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;physically handicapped;Physicians;Population;Populations at Risk;Preparation;Process;promote resilience;Prospective, cohort study;psychologic;psychological distress;psychological symptom;psychosocial;psychosocial development;psychosocial outcome;psychosocial wellbeing;Qualitative Methods;Qualitative Research;Quality of life;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Training;resilience;resilience scale;Resources;Risk;Scientist;Self Efficacy;Severity of illness;skills;social;social skills;Statistical Data Interpretation;Stress;stress management;Structure;Symptom Burden;Testing;Thinking;tool;treatment as usual;Universities;Washington;Well in self;Work;young adult

PROJECT_TITLE: Assessing and Promoting Resilience in Adults with Adult Congenital Heart Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally while a vital step for EHR-based research is valid, accurate, and reliable phenotyping. Conventional approaches to phenotyping are ad hoc, domain expert dependent, rule-based, and usually specific to EHR environments. We propose to refine, validate, and share a new generalizable high-throughput approach: Phenotyping by Measured, Automated Profile (PheMAP) that allows researchers to rapidly and accurately determine the status of thousands of phenotypes for millions of individuals with minimal human intervention.

PI_NAMEs: WEI, WEI-QI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;Benchmarking;biobank;Biological;biomedical ontology;Catalogs;Clinical;Clinical Data;clinically relevant;cost;Data;data modeling;Data Set;Dementia;Disease;Effectiveness;EHR research;Electronic Health Record;Electronic Medical Records and Genomics Network;Environment;Evaluation;experience;Genes;genome wide association study;genome-wide;Genotype;Goals;Grant;Healthcare;Heritability;Heterogeneity;Human;Hypothyroidism;implementation tool;Individual;Institution;interest;Intervention;Investments;Knowledge;Left;Link;Machine Learning;Maps;Measures;Medical center;MedlinePlus;Modeling;Non-Insulin-Dependent Diabetes Mellitus;novel;off-label drug;off-label use;Ontology;Outcome;Performance;Pharmaceutical Preparations;phenome;Phenotype;phenotyping algorithm;Physicians;portability;prototype;Publishing;Reporting;Research;Research Personnel;Resources;Sampling;Sensorineural Hearing Loss;Signal Transduction;Site;Statistical Models;Terminology;Time;tool;trait;Validation;Work

PROJECT_TITLE: PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative This project will probe the transformative idea that enhancing one carbon (1C) metabolism will increase anti-tumor immune functions and synergize with ICB. We will define how formate and 1C metabolism improve T cell function to synergize with PD-1 blockade, and identify metabolic pathways downstream of 1C metabolism that enhance T cell functions. These studies will illuminate mechanisms by which 1C metabolism and metabolic support with formate enhance ICB, and identify novel targets and strategies for improving cancer immunotherapy outcomes.

PI_NAMEs: AGAR, NATHALIE YR;HAIGIS, MARCIA ;SHARPE, ARLENE H. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affect;Anabolism;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigens;ATAC-seq;Atlases;cancer cell;cancer immunotherapy;cancer therapy;Carbon;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;conditional knockout;cytotoxic;Data;Effectiveness;Effector Cell;effector T cell;Enzymes;Epigenetic Process;exhaust;Formates;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Transcription;Glucose;Glutathione;Glycine;Goals;Heterogeneity;Immune;immune checkpoint blockade;immune function;Immune response;Immune system;Immunofluorescence Immunologic;Immunotherapy;improved;In Vitro;in vivo;Individual;innovation;Intercellular Fluid;Knockout Mice;Ligands;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma Tumor;Memory;Metabolic;metabolic fitness;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Methionine;Modeling;Molecular;Mus;NADP;neoplastic cell;new therapeutic target;novel;Nucleotides;Outcome;Pathway interactions;patient subsets;PD-1 blockade;Periodicity;Population;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;Purines;Resolution;response;Role;Serine;single-cell RNA sequencing;Source;Supplementation;synergism;System;T cell response;T-Cell Activation;T-Lymphocyte;Testing;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression

PROJECT_TITLE: Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(09)F]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Sepsis

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The Acute Respiratory Distress Syndrome (ARDS) is a devastating illness that causes substantial morbidity and mortality in afflicted patients. No medical therapy is available to target the underlying mechanistic causes of this disease process. The bacteria methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of ARDS, and this proposal seeks to better understand how MRSA infection results in disease, as well as determine the potential therapeutic effectiveness of a novel FTY720 analog in a clinically relevant model of MRSA ARDS.

PI_NAMEs: DUDEK, STEVEN M (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Agonist;analog;Antibiotic Resistance;Attenuated;Bacteria;Blood flow;ChIP-seq;clinically relevant;Critical Illness;CYP1A1 gene;Data;Development;Disease;efficacy evaluation;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;Functional disorder;Gene Expression;Genes;Gram-Positive Bacteria;Health;Histone Acetylation;Histone Deacetylase;Human;Immune response;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;Injury;insight;Intervention;Knowledge;Life;Lung;lung injury;Medical;methicillin resistant Staphylococcus aureus;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;new therapeutic target;novel;novel therapeutics;organ injury;Organism;Pathogenicity;Patients;Permeability;pharmacologic;Pharmacologic Substance;Phospholipids;phosphonate;Play;Pneumonia;Pre-Clinical Model;Process;Property;protective pathway;receptor;Reporting;Resistance;resistant strain;response;Role;screening;Sepsis;sepsis induced ARDS;Signal Transduction;Source;sphingosine 1-phosphate;Staphylococcus aureus;Staphylococcus aureus infection;Targeted Research;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic effectiveness;therapy development;tool;trafficking;Ubiquitination;Vascular Endothelial Cell;Virulent;Work

PROJECT_TITLE: Pathobiology of MRSA-induced Endothelial Permeability and Acute Lung Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Racial/ethnic minority children who undergo surgery have worse outcomes compared to white or more affluent peers. Positive relationships and communication between the family and surgeon are essential to make high quality treatment decisions and overcome racial/ethnic disparities in clinical outcomes. This study explores generation of automated methods of analyzing parent-clinician communication, with the goal of identifying effective communication behaviors that can be easily taught to pediatric surgical clinicians.

PI_NAMEs: BOSS, EMILY FRANCES (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Address;analytical method;Attitude;automated text message;care delivery;Caring;Child;Clinical;Code;Communication;communication behavior;Communication Methods;computerized;Conflict (Psychology);Consultations;cost;cost effectiveness;cultural competence;design;Development;Dimensions;Disease;Disparity;disparity reduction;distrust;Educational process of instructing;Equipoise;Equity;ethnic difference;ethnic disparity;ethnic minority;experience;Family;Family Physicians;Feedback;Funding;Generations;Goals;health care disparity;Human;improved;innovation;Intervention;Language;Length of Stay;Linguistics;Manuals;Measurement;Measures;Methodology;Methods;Minor;Minority;minority children;minority patient;mortality;multidisciplinary;novel;Operative Surgical Procedures;Outcome;Parents;Participant;patient-clinician communication;Patient-Focused Outcomes;Patients;pediatric health outcomes;Pediatric Surgical Procedures;peer;Physicians;poor health outcome;Postoperative Period;Process;programs;provider communication;Psychology;racial difference;racial disparity;racial minority;readmission rates;Recovery;Relationship-Building;Repeat Surgery;Research;Research Design;Science;shared decision making;skills;skills training;social;Social Distance;Source;Specialist;Specificity;Speech;Structure;Surgeon;surgery outcome;Surgical complication;System;Text;therapy development;Time;tool;Training Programs;Transcript;Translations;Visit;Vocabulary

PROJECT_TITLE: Understanding Clinician-Parent Interaction to Reduce Disparities and Improve Quality of Pediatric Surgical Care

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Bilingual children with autism spectrum disorder (ASD), especially those with minimal spoken language skills, have long been excluded from research and may have limited access to interventions that support their dual- language needs. This project uses a sequential mixed-methods design to examine the dual-language communication and social-cognitive skills of children with ASD with a range of verbal abilities, contextualized by the experiences of their families in making language choices and seeking support services. The long-term goal of this work is to collaborate with families and providers to develop community-based interventions that promote the linguistic and social-cognitive development of bilingual children with ASD.

PI_NAMEs: GROSS, MEGAN CHAYA (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Affect;Age;Area;Augmentative and Alternative Communication;autism spectrum disorder;autistic children;Behavior;bilingualism;career development;Caregivers;Child;Child Development;Child Support;Clinical;Code;Cognitive;cognitive development;cognitive process;cognitive skill;Collaborations;Communication;Communication impairment;Communities;community based participatory research;community based research;community intervention;Data;design;Development;Diagnosis;Environment;Evaluation;Exclusion;executive function;experience;Exposure to;Family;Family member;family support;flexibility;Frequencies;Future;Goals;Hearing;Home;Hour;Household;Human;improved;improved outcome;Intervention;Interview;K-Series Research Career Programs;Language;Language Development;language processing;Language Therapy;Learning;Linguistics;Maintenance;Measures;Mentors;Methods;minimally verbal;National Institute on Deafness and Other Communication Disorders;natural language;Parents;peer;perspective taking;Phase;phrases;Population;Prevention;Professional Education;Provider;Psychology;Public Health;Questionnaires;Reporting;Research;Role;Sampling;Schools;service providers;Services;skills;social;Social Development;Source;Spanish;Speech;Strategic Planning;Structure;teacher;theory of mind;Thinking;Time;Training;United States;Variant;verbal;visual tracking;Voice;Work

PROJECT_TITLE: Dual-Language Communication and Social-Cognitive Skills in Bilingual Children with ASD

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: PHARMACOLOGY

PHR: These studies are pertinent to public health since they aim to discover proteins that can serve as drug targets in a group of human parasitic worms call schistosomes, that infect 200 million people. Completion of the proposed research could aid in the discovery of new drugs to combat disease caused by this important human parasite

PI_NAMEs: COLLINS, JAMES J (contact);PHILLIPS, MARGARET A.

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Address;Adult;assay development;Binding;Biological;Biological Assay;Biology;Chemicals;Chemistry;combat;Data;Disease;drug development;drug discovery;Drug Targeting;druggable target;Enzymes;experimental study;Foundations;Future;Generations;Genes;Genetic;Goals;Helminths;high throughput screening;Human;in silico;In Vitro;in vitro activity;in vivo;Individual;Infection;knock-down;Laboratories;Lead;lead optimization;Length;Life Cycle Stages;loss of function;Magic;Medical;Mus;neuromuscular function;new therapeutic target;next generation;novel therapeutics;Parasite resistance;Parasites;Performance;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Praziquantel;Praziquantel resistance;Productivity;programs;Proteins;Public Health;Ramp;Recombinants;Research;RNA Interference;RNA interference screen;Schistosoma;Schistosoma mansoni;Schistosomiasis;screening;small molecule;small molecule libraries;therapeutic target;Validation

PROJECT_TITLE: Drug Target Discovery, Validation, and Prioritization for Schistosomiasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Cardiac hypertrophy occurs from cardiovascular diseases and can lead to heart failure, disability, and death. This project will determine how a coordinated modification on multiple proteins during physiological stress affects heart function. The successful completion of this project will provide new information into the causes of heart failure that can be developed into new therapies.

PI_NAMEs: OLSON, AARON K (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Affect;Anabolism;Animal Model;Animals;Aorta;aorta constriction;Aortic coarctation;Aortic Valve Stenosis;Cardiac;Cardiovascular Diseases;Cessation of life;Citric Acid Cycle;Clinical;Data;disability;Disease;Energy-Generating Resources;enzyme pathway;Enzymes;Equilibrium;Evaluation;experimental study;fatty acid oxidation;Fatty Acids;fructose-6-phosphate;Generations;Glucose;glucose metabolism;Glutamine;Glycolysis;Goals;Growth;Heart;Heart failure;heart function;Heart Hypertrophy;heart metabolism;Hexosamines;Human;Hypertension;Hypertrophy;improved;insight;Knock-out;Knowledge;Left Ventricular Function;Link;Measures;Mediating;Metabolic;Metabolism;Methods;Modification;Myocardial dysfunction;novel therapeutic intervention;novel therapeutics;Organ;Outcome;overexpression;oxidation;Pathologic;Pathway interactions;Patients;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Pharmaceutical Preparations;Physiological;Pilot Projects;Post-Translational Protein Processing;preference;preservation;pressure;prevent;Production;Protein Isoforms;Proteins;Regulation;response;Role;Source;Stenosis;Stress;structural heart disease;targeted treatment;Testing;Therapeutic;Transgenic Mice;Ventricular Dysfunction;Ventricular Remodeling

PROJECT_TITLE: Hexosamine biosynthesis pathway metabolism during cardiac hypertrophy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Digestive Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: The total body irradiation induced acute gastrointestinal syndrome is mitigated by administration of an engineered probiotic bacterium Lactobacillus-reuteri, LR-IL-22, which anatomically targets the radiation damaged intestinal crypt stem cells to restore intestinal integrity and is superior to systemic/parenteral administration of IL-22. We have demonstrated that intraoral (gavage) of LR-IL-22 mitigates the gastrointestinal syndrome by restoring irradiation-suppressed gene transcription in intestinal stem cells. We will now establish that LR-IL-22 and a new improved version modulates irradiation-induced molecular biologic cell death pathways in intestinal stem cells, preserves their crypt regeneration capacity, and mitigates the irradiation- induced acute GI syndrome.

PI_NAMEs: GREENBERGER, JOEL S (contact)

PROGRAM_OFFICER_NAME: RIOS, CARMEN I

PROJECT_TERMS: Acute;Address;Adhesions;Anatomy;ARNT gene;Aryl Hydrocarbon Receptor;Bacteria;Biological;Biological Containment;Blood Vessels;Cell Death;cell injury;Cells;Chemotactic Factors;Chromosomes;clinical application;Containment;Cytolysis;Data;Drug Delivery Systems;Effectiveness;Engineered Probiotics;Engineering;Environment;experimental study;gastrointestinal;Gastrointestinal tract structure;Generations;Genes;Genetic Transcription;Goals;gut microbiota;Hematopoietic;improved;In Vitro;inducible Cre;interleukin-22;intestinal crypt;Intestines;irradiation;Lactobacillus reuteri;LGR5 gene;Lymphocyte;Lymphoid Cell;Marrow;Measures;Mediating;microbial;Molecular;Molecular Mechanisms of Action;Mus;mutant;Natural regeneration;novel;Oral;Oral Administration;parenteral administration;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasmids;preservation;prevent;Probiotics;Production;Property;Proteins;Radiation;radiation countermeasure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation mitigator;Recombinants;Recovery;recruit;Regenerative capacity;response;Role;Safety;safety engineering;Signal Pathway;stem cell niche;stem cells;Syndrome;Testing;Therapeutic;transcriptome sequencing;Translations;Treatment Efficacy;Whole-Body Irradiation;Wild Type Mouse;γδ T cells

PROJECT_TITLE: LR-IL-22 for Mitigation and Management of Radiation Injuries


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative  This project aims to develop advanced methods and computational tools to address biases and disparities caused by the lack of representation of non-European populations in large-scale genomic datasets and biobanks. We will develop transfer learning methods to improve polygenic risk prediction in under-represented populations by leveraging similarities in genetic architectures across diverse populations and related phenotypes, as well as communication-efﬁcient and privacy-preserving federated algorithms that integrate larger bodies of data across biobanks and large-scale genomic datasets to boost the power of association tests and risk prediction models. We will apply the proposed methods to study major depressive disorder and cardiovascular diseases using multiple national and institutional biobanks.

PI_NAMEs: DUAN, RUI  (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: Accounting;Address;African ancestry;Algorithms;All of Us Research Program;Assessment tool;biobank;Biological;Cardiovascular Diseases;clinical risk;Cloud Computing;cloud platform;cluster computing;Communication;Community Medicine;Complex;Computer software;computerized tools;cost effective;Data;Data Collection;Data Commons;data integration;data privacy;Disease;disorder risk;Disparity;Disparity population;diverse data;Electronic Health Record;Environment;European ancestry;federated learning;Genetic;genetic architecture;Genetic Risk;genome wide association study;genomic data;Genotype;Goals;graph knowledge base;health disparity;Healthcare;Heritability;Heterogeneity;High Performance Computing;High-dimensional Modeling;improved;Inequity;insight;Institution;Joints;Knowledge;knowledge graph;Learning;learning algorithm;learning strategy;Link;Major Depressive Disorder;Mental disorders;Meta-Analysis;Methodology;Methods;Minority Groups;Modeling;multi-ethnic;multi-task learning;novel;open source;Participant;participant enrollment;Patients;Performance;Phenotype;pleiotropism;polygenic risk score;Population;Population Heterogeneity;precision medicine;privacy preservation;privacy protection;programs;Rare Diseases;Reproducibility;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;Sample Size;Sampling;Source;statistics;Techniques;Testing;trait;Trans-Omics for Precision Medicine;transfer learning;Translating;Underrepresented Populations;United States National Institutes of Health;user friendly software;Variant

PROJECT_TITLE: Federated and transfer learning methods for cross-ancestry and cross-phenotype integration of genomic datasets

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Endocrine Disruptors;Estrogen;Genetics;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Bisphenol A (BPA) is a ubiquitous, endocrine disrupting compound with controversial carcinogenic properties. Our research will test a complete mechanism underlying liver cancer observed in mice exposed to BPA during development. This work will shed critical light on mechanisms underlying the carcinogenic potential of BPA, which will directly inform both epidemiological study design and human health risks due to BPA exposure.

PI_NAMEs: WEINHOUSE, CAREN  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acetylcysteine;Adult;Aflatoxin B1;Africa;Agonist;Alcohol abuse;antagonist;Antioxidants;Binding;Biological Availability;bisphenol A;Cancer Etiology;cancer initiation;carcinogenesis;Carcinogenesis Mechanism;carcinogenicity;Carcinogens;Cessation of life;Characteristics;Chemicals;Chronic;Conceptions;Country;Data;Development;Disease;disorder prevention;DNA;DNA Damage;DNA Repair Disorder;DNA Sequence Alteration;Dose;driver mutation;Endocrine;Endocrine disruption;Endocrine Disruptors;Enhancers;Environment;Environmental Pollutants;Environmental Risk Factor;epidemiology study;ESR1 gene;Estrogens;exome sequencing;exposed human population;Exposure to;Far East;Female;Frequencies;Gene Expression;Genetic Transcription;genome-wide;genotoxicity;Half-Life;Health;Hepatitis B;Hepatitis C;Hepatocarcinogenesis;Human;In Vitro;in vivo evaluation;Incidence;Infection;Link;Liver;male;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;mortality;Mus;Mutagenesis;Mutagenicity Tests;Mutation;neonatal exposure;nonalcoholic steatohepatitis;novel;oxidative DNA damage;Pathway interactions;pollutant;Predisposition;prevent;Primary carcinoma of the liver cells;Prognosis;Property;protective effect;Puberty;Reactive Oxygen Species;Reporting;Research;Research Design;response;Risk;Risk Factors;Rodent;Role;Sex Differences;Signal Transduction;South America;Survival Rate;Testing;Tissues;transcription factor;Weaning;Work

PROJECT_TITLE: Understanding mechanisms of liver carcinogenesis following developmental BPA exposure


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Infectious Diseases;Sepsis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: Sepsis is a common and deadly disease characterized by organ failure due to a dysfunctional immune response to infection; yet there is much we do not understand about the immune response to sepsis because of practical limitations in studying it broadly in humans. Our goal is to optimize and validate a simple whole blood cryoprecipitation method using 2 mL of patient blood that we developed to make deep immune profiling via single cell RNA sequencing (scRNA-seq) broadly available for multicenter clinical investigations in sepsis. This will enable detailed studies of broad and diverse populations of sepsis patients to discover how each individual immune cell type is responding to infection, which will greatly expand our understanding of underlying disease mechanisms, facilitate development of novel immune-directed therapies, and characterize patient subtypes by their immune response signature that might respond favorably to certain therapies over others.

PI_NAMEs: BHATTACHARYYA, ROBY PAUL;FILBIN, MICHAEL  (contact);SHAPIRO, NATHAN I

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;adjudication;B-Lymphocytes;Biological;Blood;Blood Cells;Blood specimen;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Clinical;clinical center;Clinical Data;clinical investigation;clinical research site;Clinical Trials;cohort;Collection;Complex;cost;Coupled;Cryopreservation;Cryopreserved Cell;Data;Development;Diagnosis;Disease;disease heterogeneity;Enrollment;Evolution;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Health Expenditures;Heterogeneity;Hospitalization;Hospitals;Human;Immune;Immune response;Immunologic Stimulation;Immunologics;Immunology;Immunotherapy;In Vitro;Individual;Infection;insight;Institutional Review Boards;Kinetics;Maps;Measures;Methods;monocyte;Morbidity - disease rate;mortality;Multicenter Studies;Neurosciences;novel;Oncology;Organ;Organ failure;Outcome;Pathway interactions;patient population;patient subsets;Patients;Phase;Population;Population Heterogeneity;preservation;Procedures;Process;programs;Recovery;repository;Reproducibility;response;RNA;Sampling;Scientist;Sepsis;septic patients;single-cell RNA sequencing;Site;Standardization;Stimulus;Syndrome;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic Trials;Time;transcriptome sequencing;treatment effect;Whole Blood

PROJECT_TITLE: Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE As vaccine and other pathogen-specific interventions for enteric infectious diseases (EID) come to market in the coming years, there will be a pressing need to identify areas of transmission risk and monitor EID burden trends under a changing climate. We propose to apply a big data approach to the mapping of EIDs combining advanced molecular diagnostics and geostatistical analyses with global earth observation-derived datasets to provide generalizable estimates of the geographical distribution of these outcomes and their environmental drivers via an interactive web-based dashboard. These outcomes will provide the research and stakeholder communities the data inputs that are urgently needed for targeting existing and novel interventions to priority populations in Low- and Middle-Income Countries.

PI_NAMEs: COLSTON, JOSH M (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Adult;Age;age group;Area;Bacteria;Big Data;Biological Process;Biometry;burden of illness;Campylobacter;career development;central database;Cessation of life;Child;Child Health;Childhood;Cholera;Climate;climate change;Communicable Diseases;Communities;comparative;Country;COVID-19;Cryptosporidium;dashboard;Data;data dashboard;Data Set;Databases;Development;Development Plans;Diagnosis;Diagnostic;diagnostic technologies;Differential Diagnosis;disability-adjusted life years;Disease;Disease Outcome;economic outcome;Enteral;enteric pathogen;Epidemiologist;Etiology;evidence base;Exclusion;Funding;Geographic Distribution;Geography;Goals;Health;Health Information System;HIV;Household;improved;inter-institutional;Interdisciplinary Study;International;Intervention;large datasets;low and middle-income countries;Lower Respiratory Tract Infection;Malaria;Maps;Marketing;Mentors;Mentorship;Methodology;Methods;Modeling;Modernization;Molecular;molecular diagnostics;Monitor;National Institute of Allergy and Infectious Disease;Norovirus;novel;novel vaccines;Outcome;pathogen;peer;peer learning;Perception;Personal Satisfaction;Planet Earth;Population;Population Intervention;Populations at Risk;Prevalence;priority pathogen;Process;Public Health;public repository;Publications;remote sensing;Reporting;Research;Research Activity;Research Personnel;Resolution;Resources;Risk;Risk Factors;Sampling Studies;Secure;Shigella;skills;sociodemographic factors;sociodemographics;Source;spatiotemporal;Standardization;stool sample;success;surveillance study;Surveys;Target Populations;Testing;Time;tool;Training;transmission process;trend;United States National Aeronautics and Space Administration;Universities;Update;vaccine candidate;Vaccines;Variant;Viral;web page;web portal;years of life lost

PROJECT_TITLE: The Planetary Child Health Observatory: an interdisciplinary research initiative and web-based dashboard for mapping enteric infectious diseases and their risk factors and interventions in LMICs

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Birth defects occur in 3-5% of infants, are a leading cause of childhood mortality, and are a large burden to families and society. Despite advances in genome sequencing, often the gene and variant that causes a birth defect is unknown, as are the genetic, cell biological, and pathogenetic mechanisms. We propose a screening platform including sequential bioinformatic analysis and experiments in multiple model systems (worm, fly, fish, mouse, or established human embryonic stem cell lines) to provide functional data in support of new birth defect genes and molecular diagnosis, and to obtain disease relevant mechanistic information necessary to design treatment strategies.

PI_NAMEs: JOHNSON, AARON N;KROLL, KRISTEN L;ORNITZ, DAVID M;PAK, STEPHEN C;SOLNICAKREZEL, LILIANNA  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Acceleration;Alleles;analysis pipeline;Bioinformatics;bioinformatics pipeline;Biological;Biological Models;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;causal variant;Cells;Childhood;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Congenital Abnormality;cost effectiveness;Cytoskeleton;Data;Databases;developmental disease;Diagnosis;Disease;disease model;disease phenotype;Disease Progression;Dominant-Negative Mutation;Drosophila genus;Embryo;Etiology;exome;exome sequencing;experience;experimental study;Family;family burden;Fishes;fly;Gene Dosage;gene function;Gene Mutation;Genes;Genetic;Genetic Screening;genetic variant;genome sequencing;Genomics;Grant;Hospitalization;Human;Human Biology;human embryonic stem cell;human embryonic stem cell line;human genomics;in vivo;Infant;Injections;innovation;insight;Intellectual functioning disability;Investigation;Knock-in;Knock-out;Laboratory Organism;Link;Literature;Mediating;Messenger RNA;model organism;Modeling;Molecular;Molecular Diagnosis;mortality;Mus;Mutation;Neurologic;next generation sequencing;Organism;Orthologous Gene;patient screening;Patients;Phenotype;Physiological;Prevention;primary care clinician;Probability;proband;Provider;Publishing;Rare Diseases;RNA Interference;RNA interference screen;screening;Societies;Speed;Structural Congenital Anomalies;success;Symptoms;System;therapy design;Tissues;treatment strategy;Universities;Variant;Vertebrates;Washington;Work;Zebrafish

PROJECT_TITLE: Multi-organism platform for functional assessment of human birth defect associated genomic variants

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects approximately 1% of the population, yet its neural and cognitive bases remain elusive. This proposal will use complex video stimuli together with functional neuroimaging (fMRI) and computational methods to identify brain regions that best predict ASD groups, subgroups, and traits, identify the underlying stimulus features that drive these neural differences, and make the data and tools we generate maximally available for others to use and build upon.

PI_NAMEs: KENNEDY, DANIEL PATRICK (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Affect;Algorithms;Auditory;autism spectrum disorder;Back;base;Biological Markers;Brain;brain abnormalities;brain based;Brain region;Classification;Clinical;Code;Cognitive;cognitive process;Collaborations;Complex;Computer Vision Systems;Computing Methodologies;Data;Data Collection;data collection site;Data Set;data sharing;design;Dimensions;Dissociation;Ensure;Eye;Face;Fostering;Functional Magnetic Resonance Imaging;Funding;Future;gaze;Goals;Head;Heterogeneity;improved;Indiana;Individual;Individual Differences;individual variation;individuals with autism spectrum disorder;insight;Institution;Investigation;Iowa;Learning;Link;Machine Learning;Manuals;Maps;Measurement;Measures;Methods;Modeling;Modernization;Motion;Movement;neural;neuroimaging;neuroimaging marker;neuromechanism;novel;Participant;Pattern;performance site;Phenotype;Population;Process;Property;Protocols documentation;quality assurance;Regional Anatomy;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;response;Rest;Risk;Sampling;Scanning;Semantics;Signal Transduction;Site;social;social cognition;social situation;Source;Speech;Standardization;Stimulus;Structure;Subgroup;Techniques;Testing;Time;tool;trait;Universities;Validation;Variant;Visual;visual tracking;Work

PROJECT_TITLE: Using complex video stimuli to elucidate atypical brain functioning in ASD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PHR: Narrative Auditory hallucinations in schizophrenia may be rooted in reduced inhibition of abnormal temporoparietal cortex activity due to auditory control network dysfunction. We will investigate neural markers of target engagement to further develop auditory control enhancement (ACE) as a novel, inexpensive, and noninvasive intervention to address treatment-refractory auditory hallucinations in schizophrenia.

PI_NAMEs: COFFMAN, BRIAN A (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Acoustic Stimulation;Acute;Address;Anodes;Antipsychotic Agents;Area;Attention;Auditory;Auditory area;Auditory Hallucination;Auditory system;Behavior Control;behavior measurement;Behavioral;Behavioral Assay;Biological;Biophysics;blood oxygen level dependent;blood oxygenation level dependent response;brain circuitry;brain tissue;Cathodes;Cerebrovascular Circulation;Clinical;Cognitive;cognitive control;cognitive enhancement;cognitive performance;common symptom;Computer Models;Data;design;Development;Disease;distraction;Dose;Echo-Planar Imaging;Effectiveness;efficacy trial;electric field;Electrodes;Electroencephalography;Electromagnetic Fields;Elements;Etiology;experimental study;follow-up;Functional disorder;hemodynamics;Hypersensitivity;Impaired cognition;Impairment;improved;improved outcome;Individual;Institutionalization;Intervention;Language;Lead;Learning;Left;Lifelong disability;magnetic field;Magnetic Resonance Imaging;Measures;medication compliance;Metabolic;Methods;Modeling;network dysfunction;neural;Neurobehavioral Manifestations;neurophysiology;noninvasive brain stimulation;novel;Orthostatic Hypotension;oscillatory blood flow;participant enrollment;Persons;Pharmaceutical Preparations;Pharmacotherapy;Prefrontal Cortex;Psychiatric Hospitals;psychotic symptoms;Refractory;Reporting;Resistance;response;Rest;Schizophrenia;Sedation procedure;Severities;Sexual Dysfunction;side effect;Surveys;Symptoms;System;Testing;Time;Training;Training Programs;transcranial direct current stimulation;Treatment Efficacy;Update;verbal;visual search

PROJECT_TITLE: Targeting the Auditory Control Network with Auditory Control Enhancement (ACE) in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Natural sounds like speech contain information at many different timescales (e.g. phonemes, syllables, words), but how the human brain extracts this information remains unclear. Understanding this process is critical to understanding how hearing impairment degrades speech perception. The proposed research will reveal the organization of neural timescales in the brain, and how this organization facilitates the coding of natural sounds like speech, which is a critical first step in understanding how this code is impaired by hearing loss.

PI_NAMEs: NORMAN-HAIGNERE, SAMUEL V (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Address;Animals;Area;Auditory area;Biomedical Engineering;Brain;Categories;Cells;clinically significant;Code;Collaborations;Communication;Complex;Computational Technique;Computing Methodologies;Data;Data Set;Dedications;deep neural network;Electrocorticogram;Engineering;experience;experimental study;Family member;Functional Magnetic Resonance Imaging;Goals;Grant;hearing impairment;Human;Learning;Measures;Methods;millisecond;Modeling;Music;neural;Neural Network Simulation;neuromechanism;Neurosciences;Noise;Persons;Physiology;Population;Process;programs;Property;Psychophysics;receptive field;Research;Research Personnel;response;Restaurants;Reverse engineering;Sensory;skills;sound;Speech;Speech Perception;Statistical Models;Stimulus;Structure;System;Techniques;Testing;theories;Time;Training;Voice;Work

PROJECT_TITLE: Revealing the organization and functional significance of neural timescales inauditory cortex


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_NAME: TURING MEDICAL TECHNOLOGIES INC

PHR: Project Narrative Magnetic resonance imaging (MRI) has unrivaled clinical and research utility, is non-invasive, and provides extremely high spatial resolution, however, MRIs have an Achilles heel: subject motion during scanning greatly diminishes the quality of the resulting images. We have developed software (FIRMM) that allows for non- invasive monitoring and reduction of subject motion during brain MRIs. In this proposal we complete late-stage development and commercialization readiness preparations to bring 510(k) FDA-cleared FIRMM into clinical practice.

PI_NAMEs: BERTOLERO, MAXWELL ;KING, KEVIN  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: Adult;Age;American;Anesthesia procedures;awake;Award;Back;base;Behavioral;biobehavior;Biofeedback;Black Box;Brain imaging;brain magnetic resonance imaging;Categories;Child;Childhood;Client satisfaction;Clinical;clinical care;clinical practice;Clinical Research;Code;combat;commercialization;commercialization readiness;Computer software;Conscious;cost;cost estimate;Current Procedural Terminology;Current Procedural Terminology Codes;Data;Development;diagnostic tool;Elderly;Emerging Technologies;Ensure;experience;Face;Feedback;Feeds;Functional Magnetic Resonance Imaging;Goals;Grant;Head;Health;high resolution imaging;Hospitals;Image;improved;Institution;interest;Letters;Magnetic Resonance Imaging;Market Research;Marketing;Measurement;Medical;Methods;Monitor;Motion;Movement;MRI Scans;non-invasive monitor;Participant;Patients;Physicians;Predisposition;Preparation;prevent;Price;price lists;programs;Protocols documentation;Questionnaires;Radiation;Relaxation;Research;Research Subjects;Resolution;Risk;Robin bird;Safety;Scanning;Secure;Sedation procedure;Site;Societies;software development;success;System;Technology;Testing;Time;Training;Translating;United States;United States Centers for Medicare and Medicaid Services;usability;Visual;visual feedback;wasting;Work

PROJECT_TITLE: Commercialization readiness of visual biofeedback to reduce head motion during MRI scans


ORG_CITY: NEW ORLEANS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: The kainic acid model of temporal lobe epilepsy has greatly contributed to the understanding of the molecular, cellular and pharmacological mechanisms underlying epileptogenesis. Novel therapeutic agents to reduce excessive glutamate release from synapses could potentially prevent neuropathological features that are seen in patients with epilepsy.

PI_NAMEs: ERICKSON, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acids;Acute;Affect;Affinity;Age;alpha ketoglutarate;Animal Model;Anticonvulsants;benzothiazole;Biochemical;Brain;Central Nervous System Diseases;Chronic;Complementary DNA;Cytoplasm;Development;Dissociation;Down-Regulation;Electrophysiology (science);Epilepsy;Epileptogenesis;Excitatory Synapse;excitotoxicity;Exocytosis;experimental study;Future;gamma-Aminobutyric Acid;Glutamates;Glutamine;Goals;hippocampal pyramidal neuron;Hippocampus;Human;In Vitro;in vitro Assay;in vivo;in vivo Model;Induced Heart Arrest;Induced Neurons;Intervention;Kainic Acid;Kinetics;knock-down;Link;Location;Maintenance;Mediating;Modeling;Molecular;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;nerve injury;neural;Neurobiology;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;neuroprotection;neurotransmission;novel;novel therapeutics;Patients;Persons;pharmacologic;Plasmids;postsynaptic;presynaptic;Presynaptic Terminals;prevent;Property;Rattus;Resistance;Resolution;Riluzole;Role;Seizures;side effect;Slice;small hairpin RNA;Status Epilepticus;Synapses;System;targeted treatment;Temporal Lobe Epilepsy;Testing;Therapeutic;Therapeutic Agents;Traumatic Brain Injury;uptake;Western Blotting

PROJECT_TITLE: Novel presynaptic agents to prevent glutamate-induced neural injury

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC-R]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Fibrosis, which causes dysfunction and ultimate failure of numerous tissues with aging, is characterized in part by increased tissue stiffness. Despite the profound impact of fibrosis on the health of our aging population, no adequate model system exists to study fibrotic stiffening on individual cells in real-time. This project aims to develop a dynamic material platform that enables user-directed manipulation of stiffness and to apply this system to identify aging-related changes in muscle stem cells that could lead to novel therapies to improve muscle function in aged individuals.

PI_NAMEs: MADL, CHRISTOPHER MATTHEW (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 3-Dimensional;Acute;Adhesives;adult stem cell;aged;Aging;aging population;aging related;Attention;Biochemical;Biochemistry;Biocompatible Materials;Bioinformatics;Biological Models;Biology of Aging;bioluminescence imaging;Biophysics;Cell Culture Techniques;Cells;Cessation of life;Characteristics;Chemistry;Chronic;Complex;Coupled;crosslink;Cues;Data;Defect;Deposition;Development;Disease;Engineering;Engraftment;Environment;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Faculty;Failure;Fibrosis;Fluorescence Resonance Energy Transfer;force sensor;Functional disorder;Gel;Generations;genetic approach;Goals;Health;Heritability;Histology;Human;human induced pluripotent stem cells;human model;Hydrogels;Impairment;improved;In Vitro;in vitro Model;in vivo;Individual;Inflammation;insight;intercellular communication;Life;Light;Machine Learning;Measurement;Measures;mechanical force;mechanical properties;Mechanics;mechanotransduction;medical schools;Mentors;Modeling;Molecular;Molecular Target;mouse model;Mus;Muscle;muscle aging;Muscle function;muscle progenitor cell;muscle repair;Muscular Atrophy;Natural regeneration;new therapeutic target;novel;novel therapeutics;Organ failure;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pharmaceutical Preparations;Phase;Physiological;programs;Property;Protein Engineering;Reaction;regeneration function;regeneration potential;Regenerative capacity;Rejuvenation;Research;Research Proposals;response;rho GTP-Binding Proteins;Role;single-cell RNA sequencing;Skeletal Muscle;small molecule inhibitor;stem cell function;stem cell niche;stem cell population;stem cells;Stromal Cells;Structure;System;three dimensional cell culture;three-dimensional modeling;Time;Tissue Model;tissue regeneration;tissue repair;Tissues;Traction;Training;transcriptomics;Transgenic Mice;Transplantation;viscoelasticity;wound healing;Writing

PROJECT_TITLE: Elucidating Effects of Fibrosis on Aged Stem Cells with Dynamic Biomaterials

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: The majority of Veterans will suffer from at least one chronic illness, often at great emotional and personal cost. Self-management is critical to improving physical and emotional outcomes, and many chronically ill Veterans receive self-management assistance from an informal caregiver. Yet, current clinical practices are not designed to effectively support the needs of both Veterans and their caregiver. Furthermore, self-management practices are often taught in person to the detriment of Veterans who face barriers to attending such as Veterans who live in rural areas, experience functional limitations, or experience financial challenges. This project tests a web-based self-paced behavioral intervention that targets the individual and interpersonal stress coping needs of Veterans with chronic illness and their caregivers. Results could provide an important solution to the problem of poor self-management which complicates the lives and prognosis of many Veterans.

PI_NAMEs: TRIVEDI, RANAK  (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adult;American;arm;Award;behavior change;Behavior Therapy;Behavioral;care delivery;Caregiver Burden;caregiver stress;Caregiver support;Caregivers;caregiving;Caring;Chronic;Chronic Disease;Chronically Ill;Clinical;clinical implementation;clinical practice;Cognitive;Collaborations;Communication;Consolidated Framework for Implementation Research;coping;cost;COVID-19;Data;design;Diabetes Mellitus;Diagnosis;Disease;Distress;Educational process of instructing;effectiveness evaluation;Eligibility Determination;Emotional;Ensure;Equipment and supply inventories;experience;Family Caregiver;Family member;follow-up;formative assessment;Friends;Funding;future implementation;Gender;Goals;Grant;Health;health care availability;Health Services Accessibility;Health system;Healthcare Systems;Hospitalization;implementation study;improved;improved outcome;Individual;informal caregiver;innovation;Internet;Interpersonal Relations;Intervention Trial;Interview;Investments;Learning;Life Style;Long-Term Care;Longevity;Maintenance;Measures;Mediator;Medication Management;member;Mental Depression;Methodology;mobile application;Myocardial Ischemia;novel;Online Systems;Outcome;Pain;patient engagement;Patients;peer support;Persons;Pilot Projects;pilot test;positive emotional state;Practice Management;Primary Care Physician;primary outcome;Prognosis;programs;Provider;Psychologist;Quality of life;Randomized;randomized, clinical trials;recruit;Reporting;research to practice;Resources;retention rate;rural area;Scientist;secondary outcome;Self Care;Self Management;self-management program;Services;skills;Specific qualifier value;Stress;Stress and Coping;Structure;Technology;telehealth;Telephone;telephone based;Testing;tool;treatment as usual;trial comparing;trial planning;usability;user centered design;Veterans;virtual healthcare;web site;Work

PROJECT_TITLE: A web-based program to improve chronic illness self-management by engaging patients and informal caregivers

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Social Determinants of Health

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Research in the field of neuroscience is critical to treat diseases of the nervous system that represent a growing emotional and economic burden to society, and it is imperative that we train research scientists and medical technology developers who fairly represent US society, including ethnic minorities, people from economically disadvantaged groups and people with disabilities. With this goal in mind, the University of Washington ENDURE program seeks to recruit underrepresented minority students from the Puget Sound community colleges, including the Seattle Colleges and Tacoma Community College, into a full-year research and training program at the University of Washington that will provide students with the needed skills to apply and succeed in graduate school within neuroscience-related areas.

PI_NAMEs: CHUDLER, ERIC H;DE LA IGLESIA, HORACIO O (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Area;Brain;career;cohort;college;Communication;Communities;community college;Country;Curiosities;Data Analyses;Data Collection;Development;Disabled Persons;Disease;Disparity population;Economic Burden;Economically Deprived Population;Education;education research;Educational workshop;Electronic Mail;Emerging Technologies;Emotional;Environment;ethnic minority;Evaluation;experience;Exposure to;Faculty;fascinate;First Generation College Students;follow-up;Funding;graduate school;graduate student;higher education;improved;information gathering;Institution;Journals;Laboratories;Link;Medical Technology;meetings;member;Mentors;Nervous System Disorder;Neurosciences;Neurosciences Research;novel therapeutics;online resource;Oral;Participant;Pathway interactions;Persons;posters;Program Effectiveness;programs;Questionnaires;recruit;Research;Research Training;Schedule;Science;Scientist;skills;Societies;sound;STEM career;student mentoring;Student recruitment;Students;success;summer research;Surveys;Time;tool;Training;Training Programs;transfer student;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Universities;university student;Washington;Work;Writing

PROJECT_TITLE: University of Washington ENDURE


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) poses a major public health risk, particularly to infants and children, in whom the gastrointestinal (GI) tract is a key site of colonization. To study MRSA colonization of and transmission between patients, we developed a clinically relevant murine model of GI colonization by CA-MRSA, and identified new interactions between CA-MRSA, the host immune system, and commensal bacterial populations (“microbiota”). Knowledge of how MRSA colonizes the GI tract will enable efforts to find novel therapies and vaccines to prevent and treat infections.

PI_NAMEs: SHOPSIN, BO  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Achievement;adaptive immunity;Address;Adoptive Cell Transfers;Adult;Affect;Animal Model;Antibiotics;Anus;B-Lymphocytes;Cell Shape;cell type;Cells;chemokine;Child;clinically relevant;colonization resistance;commensal bacteria;commensal microbes;Communities;community empowerment;community transmission;cytokine;Data;Development;Feasibility Studies;Future;gastrointestinal;Gastrointestinal tract structure;Genus staphylococcus;Germ-Free;Goals;Growth;gut colonization;gut microbiota;Human;Immune;Immune response;Immune system;Immunity;Infant;Infection;infection risk;Infectious Skin Diseases;innate immune mechanisms;Innate Immune Response;insight;Intestines;Knowledge;leukotoxin;Link;Lymphocyte;Lymphoid Cell;Measures;Mediating;member;methicillin resistant Staphylococcus aureus;microbiota;Modeling;mouse model;Mus;mutant;Natural Immunity;normal microbiota;novel therapeutics;novel vaccines;Omenn syndrome;Outcome Study;pathogen;Pathway interactions;Patients;permissiveness;Phenotype;Population;prevent;Probiotics;Process;Property;Public Health;Publishing;Rag1 Mouse;rational design;Rectum;resident commensals;Resistance;Resolution;response;Risk;Role;Shapes;Site;Skin;Sorting;Staphylococcus aureus;Staphylococcus aureus infection;System;T-Lymphocyte;Testing;theories;Therapeutic;Tissues;Toxin;trait;transmission process;unpublished works;Virulence;Virulence Factors;Weaning;Work

PROJECT_TITLE: Mechanisms of MRSA intestinal colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-B(02)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_DEPT: DENTISTRY

PHR: NARRATIVE The overall goal of this new collaborative project is to identify genomic risk variants for orofacial cleft (OFC) birth defects in our large resource of OFC families and controls, and then to pursue the functional significance of these variants in mouse models.

PI_NAMEs: MARAZITA, MARY L. (contact);MURRAY, STEPHEN A

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Affect;Biological Models;Biology;Caring;causal variant;Child;Cleft Lip;Cleft Palate;Code;Colon Carcinoma;comorbidity;Complex;Congenital Abnormality;cost effective;Coupled;craniofacial;Craniofacial Abnormalities;CRISPR/Cas technology;Data;Data Set;de novo mutation;Death Rate;Developing Countries;Development;Dideoxy Chain Termination DNA Sequencing;digital;Disease;Embryo;Environmental Exposure;Etiology;Face;Family;feeding;flexibility;follow-up;gene discovery;Gene Expression;Genes;genetic architecture;genetic variant;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Germ Lines;Goals;Harvest;Heritability;high risk;Histology;Hospitals;Human;improved;Incidence;Individual;Infant Mortality;innovation;insertion/deletion mutation;Investigation;Life;Link;Malignant Breast Neoplasm;Malignant neoplasm of brain;Medical;member;Mental Health;microCT;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mutation;Newborn Infant;novel;novel strategies;Nucleotides;Operative Surgical Procedures;orofacial cleft;Orthodontic;Parents;Pathway interactions;Phenotype;Public Health;Publishing;rare variant;Research;Resources;Risk;risk prediction;risk variant;Signal Transduction;Single Nucleotide Polymorphism;Speech Therapy;Structural Congenital Anomalies;Structure;System;targeted sequencing;Testing;The Jackson Laboratory;Translating;Treatment Cost;Validation;Variant;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Genomic Risk Variants in Orofacial Clefting: Discovery and Functional Validation


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative  Intra-abdominal infection-induced sepsis is a common clinical problem leading to high mortality, and there are currently no effective treatments. Fibroblastic reticular cells (FRCs) are important regulators of immune cell function that can detect infection and coordinate immune responses, and experimental therapies in mice using FRCs have successfully reduced mortality from an intra-abdominal infection. Our proposed project will help determine how distinct FRC subsets control the body’s response to overwhelming infection and also identify ways to improve the effectiveness of experimental FRC treatments, which will help us move closer to finding new treatments for sepsis in humans that will reduce morbidity and mortality.

PI_NAMEs: DENG, MEIHONG  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abdominal Infection;Adipose tissue;Adoptive Transfer;Biological Response Modifiers;Biology;Cause of Death;cecal ligation puncture;Cell Communication;Cell Physiology;Cell Therapy;Cells;Cellular biology;Cessation of life;chemokine;Clinical;clinical translation;clinically relevant;Country;Cytometry;Disease;effective therapy;Effectiveness;Escherichia coli;Experimental Models;Extracellular Matrix;Fatty acid glycerol esters;Flow Cytometry;Functional disorder;Gene Expression;Genes;Genetic Markers;Goals;Hospitals;Human;Immune;Immune response;Immune System Diseases;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Response;Innate Immune Response;Intra-abdominal;Investigational Therapies;Knowledge;Life;lymph nodes;Lymphoid;lymphoid organ;Mediating;Mesentery;Modeling;Morbidity - disease rate;mortality;Mus;novel;novel strategies;Organ;Pathogenesis;Peritonitis;Pharmacological Treatment;Play;Population;preconditioning;Production;Proliferating;Regulation;response;Reticular Cell;Rheumatoid Arthritis;Role;scaffold;Sepsis;Signal Pathway;Signal Transduction;single cell technology;single-cell RNA sequencing;Source;Spleen;Stromal Cells;subcutaneous;systemic inflammatory response;Testing;TLR9 gene;Treatment Efficacy

PROJECT_TITLE: Role of Toll-like Receptor 9 in Fibroblastic Reticular Cell-based Therapy for Intra-abdominal Sepsis


ORG_CITY: SEATTLE

PHR: PROJECT NARRATIVE The unifying theme of this proposal is the aim to use state-of-the-art technologies to investigate the basic biology of mammalian organ development and human structural birth defects. Our approach is wide-ranging, and aims to demonstrate how utilization of powerful technologies can inform many disorders. Specific methods we are proposing include: single-cell RNA sequencing and microCT imaging of mid-gestation mutant mouse embryos, and novel methods of genomic and transcriptional analysis to ascertain mutations in children with structural birth defects.

PI_NAMEs: BEIER, DAVID R. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Affect;Alprostadil;automated segmentation;Biological;Biological Models;Biology;Blood;cell type;Cells;Child;Clinical;cohort;computational anatomy;Computer Vision Systems;Congenital Abnormality;Copy Number Polymorphism;Data;Data Analyses;Data Set;deep learning;Defect;Development;Developmental Biology;Diagnosis;Disease;DNA;DNA Sequence Alteration;DNA sequencing;Embryo;Embryonic Development;Epigenetic Process;Evaluation;exome sequencing;Fetus;Frequencies;Genes;Genetic Transcription;Genetic Variation;genome sciences;Genomics;Goals;Harvest;Human;Human Development;human disease;human population genetics;Image;indexing;insight;Investigation;Knowledge;Literature;Machine Learning;machine learning model;Methods;microCT;Modification;Morphology;morphometry;mosaic;mosaic variant;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;new technology;novel;organ growth;Organogenesis;Orthologous Gene;Pathway interactions;Patients;Phenotype;Pregnancy;Probability;Prospective cohort;Proteins;Reproducibility;Research Institute;Research Personnel;response;Sampling;Science;Shapes;SHH gene;single-cell RNA sequencing;smoothened signaling pathway;Structural Congenital Anomalies;Syndrome;Techniques;Technology;Three-Dimensional Image;Three-Dimensional Imaging;Tissues;Training;transcriptome sequencing;Universities;Variant;Washington;X-Ray Computed Tomography

PROJECT_TITLE: Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Several studies have raised the intriguing possibility that some of the nonmotor behaviors might involve cerebellar outputs to the parabrachial nucleus (PBN). They provided compelling anatomical evidence for direct projections from the cerebellum to the PBN, but they did not know the extent of these connections and were unable to assess their behaviors roles. With this project we hope to show that the PBN could be a new cerebellar output channel solely for the control of numerous nonmotor behaviors.

PI_NAMEs: REGEHR, WADE G (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Aggressive behavior;Amygdaloid structure;Anatomy;Animal Model;awake;basal forebrain;Behavior;behavior influence;Brain region;Breathing;cell type;Cerebellar Cortex;Cerebellar Nuclei;Cerebellar vermis structure;Cerebellum;Cholera Toxin Protomer B;conditioned fear;Desire for food;Diameter;Epilepsy;Extinction;Fright;Heart Rate;high resolution imaging;Hippocampus;Human;Hypothalamic structure;Image;Impairment;In Situ Hybridization;in vivo;insight;Label;Medial;Mediating;Motor;motor learning;Motor Pathways;Mus;Nervous System Disorder;Neurons;novel;optogenetics;Output;parabrachial nucleus;Pathway interactions;Post-Traumatic Stress Disorders;Prevalence;Pupil;Purkinje Cells;Regulation;Rewards;Role;Short-Term Memory;Signal Transduction;Slice;Social Behavior;Synapses;targeted imaging;Testing;Thalamic structure

PROJECT_TITLE: A novel output pathway from the cerebellum for regulation of diverse non-motor behaviors

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PROJECT_TERMS: Advisory Committees;Appointment;Basic Science;Biology;Child;Clinical;Communication;Communities;design;Development;Developmental Biology;Eligibility Determination;Ensure;Ethics;experience;Faculty;Genomics;Goals;Human;human disease;Human Genetics;Human Resources;IACUC;Information Dissemination;Infrastructure;Institution;Institutional Review Boards;inter-institutional;interest;Laboratories;Logistics;meetings;Modification;Mus;National Institute of Child Health and Human Development;Occupational activity of managing finances;pediatric department;Pediatric Hospitals;Procedures;programs;Research;Research Institute;Research Personnel;Resources;Scientist;Services;Site;Structural Congenital Anomalies;Students;success;summer internship;Technology;technology development;Teleconferences;Training Support;Translational Research;Underrepresented Minority;underrepresented minority student;Universities;Washington

PROJECT_TITLE: CORE A - Administrative Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Gross chromosomal rearrangement (GCR) is a hallmark of cancer cells and a DNA double strand break (DSB) repair pathway called break-induced replication (BIR) is believed to be a major contributor to GCR. In this grant application, we will study the mechanism of BIR in repairing DSBs in mammalian cells and its potential role in causing genome instability upon oncogenic stress. Our study will provide new mechanistic insight on how genome integrity is maintained in mammalian cells and present new opportunities to explore the BIR pathway for cancer treatment.

PI_NAMEs: WU, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Abbreviations;Affect;Aphidicolin;Applications Grants;Biological Models;cancer cell;cancer therapy;CCNE1 gene;Characteristics;Chromosomal Rearrangement;Chromosome Breakage;Chromosomes;Complex;Copy Number Polymorphism;Defect;Dependence;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;Double Strand Break Repair;Event;Exhibits;Functional disorder;Gene Conversion;Genetic;Genetic Diseases;genome integrity;Genome Stability;Genomic Instability;helicase;homologous recombination;hydroxyurea;Immunoprecipitation;insight;Link;Loss of Heterozygosity;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;MCM10 gene;MCM2 gene;Mediating;Mitotic;Modification;mutant;Mutate;Mutation;neoplastic cell;Nonhomologous DNA End Joining;novel;Oncogenes;Oncogenic;Pathologic Mutagenesis;Pathway interactions;Phosphorylation;Play;prevent;Process;Proteins;Rad51 recombinase;RAS genes;recruit;repaired;replication stress;Reporter;response;Role;Single Nucleotide Polymorphism;Source;Stress;tandem mass spectrometry;telomere;tumorigenesis;Yeasts

PROJECT_TITLE: Study of Break-induced Replication in Mammalian Cells

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Prevention;Sepsis

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Sepsis-associated acute kidney injury is a major source of morbidity and mortality in critically ill children, increasing the short-term risk of mortality and the risk of developing a new disability for those who survive. This proposal will evaluate urine biomarkers to improve early detection of those at risk for pediatric sepsis- associated acute kidney injury, determine potentially modifiable risk factors related to medication therapies for sepsis that are associated with risk of acute kidney injury progression, use these biomarkers and risk factors to improve pharmacologic models predicting appropriate antibiotic dosing, and test these new pharmacologic models for antibiotic dose adjustments in a pilot trial, which may lead to more effective antibiotic treatment in sepsis with lower risk of toxicity. These results will inform future interventional studies to target therapeutic strategies to reduce or prevent pediatric sepsis-associated acute kidney injury in those at high risk, with the ultimate goal of allowing children to lead longer, healthier lives free from disability.

PI_NAMEs: FITZGERALD, JULIE C. HOLLOWS (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Antibiotic Therapy;Antibiotics;Area Under Curve;bactericide;Biological Assay;Biological Markers;biomarker identification;Blood specimen;career development;Cessation of life;Child;Childhood;Childhood Injury;Clinical;clinical practice;Clinical Research;clinical trial implementation;Clinical Trials;Computer Models;Consensus;Critical Care;Critical Illness;Critically ill children;Data;Death Rate;design;Development;Development Plans;Diagnosis;disability;Dose;Early Diagnosis;education resources;Enrollment;Environment;Excretory function;Exhibits;feasibility testing;Feedback;Functional disorder;Future;Goals;Health;hemodynamics;high risk;Histologic;Hour;improved;improved outcome;in silico;Incidence;individual patient;Infusion procedures;innovation;Institution;International;Intervention;Intervention Studies;Intervention Trial;Kidney;LCN2 gene;Lead;Length of Stay;Logistic Regressions;Measures;medical schools;Mentors;Mentorship;Methodology;Mission;Modeling;modifiable risk;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;multiplex assay;National Institute of Diabetes and Digestive and Kidney Diseases;nephrotoxicity;novel;novel marker;Organ;Outcome;patient oriented;Patients;Pediatric Hospitals;pediatric sepsis;Pennsylvania;Performance;personalized strategies;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacology;pharmacometrics;Phenotype;phenotypic biomarker;Philadelphia;pilot trial;Plasma;Population;Positioning Attribute;predictive modeling;prevent;Procedures;professor;Prospective cohort;Prospective Studies;Quality of life;rat KIM-1 protein;recruit;Regression Analysis;Research;Research Infrastructure;Research Personnel;Research Training;Risk;Risk Factors;risk mitigation;ROC Curve;Sampling;Sepsis;septic;Serum;Severities;simulation;Source;Survivors;symposium;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Toxic effect;Training;treatment as usual;trial enrollment;Universities;Urine;Vancomycin;ventilation

PROJECT_TITLE: Pediatric septic acute kidney injury: personalizing antibiotic dosing through understanding acute kidney injury risk factors and biomarker profiles

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

PROJECT_TERMS: Anatomy;bioinformatics tool;Biological;cell type;Cells;cohort;combinatorial;comparative;Computer Analysis;computerized tools;Congenital Abnormality;Data;Data Set;Development;Embryo;Embryonic Development;exome sequencing;Frequencies;gene discovery;Gene Expression;Gene Expression Profiling;Generations;Genes;Grouping;Heterozygote;Human;human disease;indexing;insight;Lethal Genes;method development;Methods;Mus;mutant;Mutate;Mutation;novel;Organogenesis;Pathway interactions;Phenotype;Play;Pregnancy;Proteins;RNA;RNA Sequences;Role;Severity of illness;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;statistics;Structural Congenital Anomalies;Techniques;Technology;Testing;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Project I - Transcriptomic Analysis of Structural Birth Defects in Mouse Developmental Mutants


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Diabetes is a chronic disease that results from deficiency of functional insulin-producing beta cells in the pancreas. One promising therapeutic approach to restoring beta cell mass is their expansion through regeneration of residual pancreatic beta cells. This Career Development proposal uses advanced genetic and epigenetic approaches in order to shed light on the fundamental mechanisms of action of the existing beta cell regenerative drugs, as well as to identify novel drug targets for diabetes therapy, and to provide essential and high-quality additional training to the applicant.

PI_NAMEs: KARAKOSE-BALIOGLU, ESRA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: 3-Dimensional;Academia;Affect;Agonist;Architecture;ATAC-seq;Beta Cell;Biochemistry;Bioinformatics;Biological Assay;Blindness;career;career development;Cell Proliferation;cell regeneration;Cells;Cellular biology;Cessation of life;Characteristics;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Structure;chromosome conformation capture;Chronic;Chronic Disease;cost;Data;Data Analyses;Databases;Development Plans;Diabetes Mellitus;diabetes mellitus therapy;Dialysis procedure;Disease;Doctor of Philosophy;Drug Combinations;drug development;Drug Targeting;Environment;Epigenetic Process;epigenetic regulation;experience;experimental analysis;experimental study;Faculty;Future;GCG gene;Genes;Genetic;Germany;Goals;Graph;High-Throughput Nucleotide Sequencing;Histones;Human;Hypertension;Immune;Impaired fasting glycaemia;inhibitor;inhibitor therapy;instructor;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Kidney Failure;Leadership;Left;Massive Parallel Sequencing;Measures;Mediating;medical schools;Meleagris gallopavo;member;Mentors;Metabolic Diseases;Metabolism;Molecular;Molecular Biology;Molecular Genetics;Myocardial Infarction;Natural regeneration;new therapeutic target;next generation sequencing;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Obesity;Organ Donor;Pancreas;Pancreas Transplantation;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Population;Postdoctoral Fellow;premature;Program Description;Proliferating;Property;receptor;regenerative;regenerative cell;Reporting;Research;Research Personnel;Residual state;response;Risk Factors;Role;Scientist;single-cell RNA sequencing;skills;stem cells;Stroke;Structure of beta Cell of islet;targeted treatment;Technology;Therapeutic;Training;transcriptome;Transforming Growth Factor beta;Transplantation;Universities;Work;Writing

PROJECT_TITLE: Epigenetic regulation in therapeutic human pancreatic beta cell proliferation

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative We have recently shown that T cells in the placental villi are active and inflammatory during intraamniotic inflammation, a process commonly associated with preterm birth. In this grant application, we will use our combined expertise in mucosal immunology (L. Konnikova), placental biology (V. Abrahams, S. Guller), placental pathology (R. Morotti) and bioinformatics (G. Tseng) to uncover placental villi T cell abnormalities in preterm births. We will use our current biorepository and ongoing collection of placental specimens to: (1) delineate T cell surface phenotypes, anatomic localization, activation mechanisms, and transcription, and TCR profiles unique to preterm placental villi and (2) interrogate the downstream effects of T cell activation on surrounding trophoblast cells as a potential mediator of preterm labor.

PI_NAMEs: KONNIKOVA, LIZA  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 37 weeks gestation;Abnormal Cell;Activities of Daily Living;adaptive immunity;adverse outcome;Agreement;Anatomy;Animal Model;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptosis;Applications Grants;Architecture;biobank;Bioinformatics;Biological Assay;Biology;Cause of Death;Cell Proliferation;Cell secretion;Cell Separation;Cell surface;Cells;Child;Childbirth;Chorionic villi;Clone Cells;Coculture Techniques;Collection;comparative;cost;Coupled;Cryopreservation;cytokine;Cytometry;Data;Development;Environment;Evaluation;experimental study;Exposure to;Gene Expression Profile;Genetic Transcription;Goals;Health;healthy pregnancy;HLA-DR Antigens;Homeostasis;Human;human data;human tissue;Immune;Immune Tolerance;Immunology;Immunophenotyping;improved;In Vitro;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;interest;Lesion;Literature;Location;Maternal-Fetal Exchange;Measures;Mediating;Mediator;Memory;Modeling;Mucous Membrane;multidisciplinary;multiple omics;nonhuman primate;novel;Organoids;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;Placenta;Placental Biology;placental trophoblasts;Population;Positioning Attribute;Pregnancy;Premature Birth;Premature Labor;prevent;Process;Production;Publishing;rational design;Reporting;repository;Research;response;Role;Sampling;Scientist;Specimen;T memory cell;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Techniques;Term Birth;Tissues;trophoblast;United States;Uterus;Work

PROJECT_TITLE: Function of T cells at the Maternal-Fetal Interface

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]