ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focuses on the continued participation of the Arkansas Center for Birth Defects Research and Prevention in the multisite, population-based study, BD-STEPS, so that we can continue to recruit cases and controls for the study, identify modifiable maternal exposures in early pregnancy using pooled data in collaborative studies that may be amenable to early prevention, and train future generations of researchers. Thus, the proposed research is relevant to the CDC's, Healthy People 2030 and other strategic priorities in Maternal, Infant, and Child Health focus area to reduce the rate of fetal (MICH- 01), infant (MICH-02) and child deaths (MICH-03) in the US.

PI_NAMEs: NEMBHARD, WENDY N (contact)

PROJECT_TITLE: Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS) Core? Arkansas Center and Stillbirth


ADMINISTERING_IC: IP

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is highly relevant to public health because of the need for modeling tools to guide more effective, rapid responses to both influenza pandemics and seasonal influenza epidemics. We propose to integrate data and models from the individual to the population level using highly-detailed information from longitudinal cohort and clinical data. These models will evaluate vaccination, antiviral distribution, and non- pharmaceutical intervention strategies to be employed for pandemic mitigation at the population level. This research is relevant to the mission of the CDC Influenza Division in that it will inform efforts to guide vaccination and treatment policies and improve initiatives to prevent and treat influenza infection.

PI_NAMEs: ZELNER, JONATHAN L (contact)

PROJECT_TITLE: IP20-003, Data driven transmission models to optimize influenza vaccination and pandemic mitigation strategies - COVID-19 Supplement


ADMINISTERING_IC: DD

IC_NAME: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

ORG_STATE: MA

PHR: Project Narrative The activities and projects proposed in this application are designed to test or generate specific hypotheses of considerable etiologic importance, with the ultimate goal of informing clinical and public health prevention messages and interventions to reduce the occurrence of birth defects. The vast majority of pregnant women take medications, yet in regard to risks of birth defects, we know little about the safety of most of these medicines; given this critical knowledge gap, many of our proposed projects focus on detailed analyses of maternal illnesses and medications as risk factors for birth defects. We will employ novel approaches such as assessing medications by their mode of action and discerning if increased risks are due to the underlying infection, its treatment, or both.

PI_NAMEs: WERLER, MARTHA M.;YAZDY, MAHSA M (contact)

PROGRAM_OFFICER_NAME: OGUNFUYI, SHAKIRATU BIOLA

PROJECT_TITLE: Massachusetts Center for Birth Defects Research and Prevention: Birth Defects Study To Evaluate Pregnancy exposureS (BD STEPS Core and Stillbirth)


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Early onset osteoarthritis (OA) is a major concern after ACL reconstruction. This project will develop a predictive model of cartilage degeneration after ACL reconstruction using a novel combination of mechanical factors, biological factors, demographics, and clinical characteristics. This information is critical to developing new targets aimed at OA prevention after ACL reconstruction.

PI_NAMEs: DEFRATE, LOUIS E. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Affect;Age;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;articular cartilage;Biological;Biological Factors;Biological Markers;Biomechanics;Body mass index;Body Weight decreased;Cartilage;cartilage degradation;Characteristics;Classification;Clinical;clinical phenotype;Cluster Analysis;Data;Data Set;Degenerative polyarthritis;demographics;Development;early onset;Etiology;experience;Future;Health;high risk;high risk population;Homeostasis;Image;improved;in vivo;Inflammation Mediators;Inflammatory;Injury;innovation;joint destruction;joint inflammation;Joints;Knee;Lubrication;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;meniscus injury;Metabolic;Metabolism;Motion;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Pain;Participant;Pathway interactions;Patient Outcomes Assessments;Patients;Pharmacologic Substance;Phenotype;Physical therapy;predictive modeling;Predisposition;prevent;Prevention;psychosocial;radiological imaging;random forest;reconstruction;Reconstructive Surgical Procedures;Relaxation;response;Risk;Role;Serum;sex;Site;Speed;Statistical Models;Synovial Fluid;targeted treatment;Techniques;Thick;three-dimensional modeling;Time;treadmill;Validation;Walking;Work

PROJECT_TITLE: In Vivo Knee Motion and ACL Biomechanics During Dynamic Activities

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Immunization;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Pre-pregnancy obesity is associated with significant adverse health outcomes for the mother including increased risk of gestational diabetes and hypertension, preeclampsia and infection. Recent studies from our laboratory revealed significant changes in immune cell function in blood samples collected from obese women at week 37 of gestation. Since immune cells play a critical role in anti-microbial defense as well as the development of chronic inflammation, this application will carry out an in-depth investigation of maternal pre-pregnancy obesity- driven changes in the functional, transcriptional, and epigenetic landscape of blood immune cells.

PI_NAMEs: MESSAOUDI, ILHEM  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 37 weeks gestation;Address;adverse outcome;adverse pregnancy outcome;age related;antimicrobial;Biology;Birth;Blood;Blood specimen;Body mass index;Categories;Cell Physiology;cell type;Cells;Cesarean section;Chronic;comorbidity;Data;Decidua;Dendritic Cells;Development;Dimensions;epidemiology study;Epigenetic Process;epigenome;Equilibrium;Exhibits;experimental study;Female of child bearing age;fetal;Fetal Growth;Frequencies;Functional disorder;Genetic Transcription;Genomics;Gestational Age;Gestational Diabetes;Gravid;Growth;Growth and Development function;Health;healthy pregnancy;Heterogeneity;Homeostasis;Host Defense;Immune;Immune system;Immunologics;Immunology;Impaired wound healing;Impairment;Induced Labor;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune System;insight;intraamniotic infection;Investigation;Labor Complications;Laboratories;Ligands;Link;Macrophage;Macrophage Activation;Maintenance;maternal outcome;Maternal-Fetal Exchange;Maternal-fetal medicine;Maternally-Acquired Immunity;Metabolic;Metabolism;Modeling;Molecular;monocyte;Natural Killer Cells;next generation sequencing;novel;obese mothers;Obesity;Outcome;peripheral blood;Phagocytes;Phenotype;Placenta;Placentation;Play;Positioning Attribute;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy hypertension;Pregnant Women;Premature Birth;prepregnancy obesity;Publishing;recruit;response;Risk;Role;Sampling;Statistical Models;surgical risk;Surgical Wound Infection;Systems Biology;Testing;Thinness;Third Pregnancy Trimester;Time;Tissues;Villous;Woman;wound healing

PROJECT_TITLE: Dysregulation of maternal immunity during pregnancy by pregravid obesity


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Current hearing aids and cochlear implants fail at the critical issue of restoring speech intelligibility in situations with noisy backgrounds, for the majority of individuals. Towards successful rehabilitation, we here examine cortical mechanisms that allow listeners to suppress background sound, with and without hearing loss.

PI_NAMEs: SHINN-CUNNINGHAM, BARBARA  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Active Listening;Affect;Animal Model;Animals;Auditory;Auditory area;auditory deprivation;auditory pathway;auditory processing;behavior prediction;Behavioral;behavioral outcome;Blood;Brain;brain based;clinically relevant;Cochlear Implants;Communication;Conductive hearing loss;Data;Development;Employment;Environment;experimental study;Frequencies;functional near infrared spectroscopy;Gerbils;Goals;Hearing;Hearing Aids;hearing impairment;Hearing Tests;hemodynamics;Human;implant design;improved;Individual;individual variation;information processing;Jird;Link;Masks;Measures;Mental Depression;model organism;Modeling;Nerve Fibers;neural;Neurons;normal hearing;Performance;Persons;Phenotype;Physiology;Positioning Attribute;predicting response;Predisposition;psychologic;Psychophysics;Quality of life;Rehabilitation therapy;resilience;response;Sensory;social;Social isolation;sound;Speech;speech in noise;Speech Intelligibility;Techniques;Testing;Time;Training;Uncertainty;Variant;Vulnerable Populations;Work;Workplace

PROJECT_TITLE: Cortical processing of informational masking

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLUMBIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Public Health Relevance Structure-function analyses of the gene therapy vector, Adeno-associated Virus (AAV) will lay a key foundation for the design of more efficient and specific vectors with improved safety profiles. Specifically, atomic-level analysis of AAV’s interactions with host cell receptors will provide a basis for modulating cell targeting, as treatments for wide-ranging disease predispositions are developed. Analysis of antibody interactions will provide a foundation for designing entry-viable immune-evading vectors, lowering therapeutic doses and a tangible risk of immuno-toxicity.

PI_NAMEs: CHAPMAN, MICHAEL S. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;adeno-associated viral vector;Algorithms;Antibodies;Binding;Biological;Biological Models;Cell Nucleus;Cells;cellular transduction;Clinical Trials;Complex;Computing Methodologies;conformational conversion;Cryo-electron tomography;Cryoelectron Microscopy;delivery vehicle;Dependovirus;design;Development;Disease;Dose;Electron Microscopy;Endosomes;Engineering;Extracellular Domain;Foundations;Freedom;gene therapy;Gene Transduction Agent;Genetic Diseases;genome wide screen;Goals;Human;Hydrogen Bonding;Immune Evasion;immunotoxicity;improved;in vivo;Location;Maps;Mediating;Molecular;Mutation;nanodisk;neutralizing antibody;neutralizing monoclonal antibodies;open source;Phospholipase A2;polyclonal antibody;Polysaccharides;Predisposition;Proteins;protonation;prototype;public health relevance;receptor;receptor binding;Receptor Cell;Resolution;restraint;Retinal Dystrophy;Risk;Role;Safety;Serum;Specificity;Spinal Muscular Atrophy;Structure;Sum;Testing;Therapeutic;vector;Viral;virus host interaction

PROJECT_TITLE: Adeno-Associated Virus Gene Therapy Vectors: Molecular Interactions on Cell Entry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Woodland Hills

ORG_NAME: TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION

ORG_STATE: CA

PHR: Narrative Stem cells differentiate into various cell lineages to form tissues that perform many functions, but current in vitro models do not capture tissue heterogeneity. This project will leverage Micro-OrganoSpheres (MOS) to develop a high-throughput screen to understand host-microbe interaction, a combinatorial indexing technique to probe local cell-cell interactions, and chimeras to study cell fate decisions and stem cell niche progression.

PI_NAMEs: SHEN, XILING  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Adult;adult stem cell;Basic Science;Cell Communication;Cell Lineage;cell type;Cells;Characteristics;Chimera organism;combinatorial;Communities;deep learning algorithm;Development;Endothelial Cells;Engraftment;Epithelium;fundamental research;Growth;Heterogeneity;high throughput screening;Homeostasis;host-microbe interactions;Immune;in vitro Model;indexing;intravital imaging;Lead;Microbe;Process;Research;Research Technics;response;self renewing cell;self-renewal;stem cell differentiation;stem cell function;stem cell niche;stem cells;Stimulus;success;Techniques;Tissues;tool

PROJECT_TITLE: Probing Tissue Heterogeneity and Stem Cell Niche with Micro-Organospheres

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Most hearing in noisy environments requires the brain to combine different types of information. In this application, we propose to study a particular brain structure, called the lateral cortex of the inferior colliculus, and how it combines different kinds of information. A better understanding of how the brain combines information will produce a basis to understand disorders of information integration such as dyslexia and autism.

PI_NAMEs: LLANO, DANIEL A (contact)

PROJECT_TERMS: Acoustics;Address;Anatomy;Area;Auditory;Auditory area;auditory pathway;Auditory Perception;Auditory system;autism spectrum disorder;awake;Axon;Behavioral;Brain;Brain region;cell type;Cells;Chemicals;Classification;Cognition Disorders;Collection;Corpus striatum structure;Data;Dendrites;Disease;Distal;Dyslexia;Electrophysiology (science);Environment;experience;experimental study;Funding;Geometry;Goals;Hearing;hearing impairment;Heterogeneity;Image;imaging approach;Inferior Colliculus;Language;Lateral;Location;Machine Learning;machine learning algorithm;Maps;Measures;Mediating;Mental Depression;Metabolic;Modernization;Molecular;molecular marker;Morphology;mosaic;mouse model;multisensory;Mus;neurochemistry;Neurons;novel;Optics;Organizational Productivity;Output;Pathway interactions;Pattern;Perception;Periodicals;Physiological;Play;Population;postsynaptic;Process;Property;response;Role;Sampling;Secure;Sensory;sensory integration;sensory stimulus;sensory system;Signal Transduction;Slice;sound;Source;Spatial Distribution;Speech;Stimulus;Stream;striosome;Structure;Support System;Synapses;System;Techniques;Thalamic structure;tool;two-photon;virtual;Work

PROJECT_TITLE: Functional organization of the auditory corticocollicular system


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: PROJECT NARRATIVE In human cells, genomic DNAs are associated with histones and form chromatin structure. Precise organization of chromatin structure is critical during cellular development and reprogramming, and their misregulation leads to various human diseases including cancer. This grant aims to identify the molecular mechanisms underlying chromatin reorganization using a cellular reprogramming model in breast cancer cells.

PI_NAMEs: TAKAKU, MOTOKI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Architecture;Binding;Binding Sites;Biological;Biological Models;Breast Cancer Cell;breast tumorigenesis;Cell Reprogramming;Cells;Cellular biology;cellular development;CHD4 gene;Chromatin;chromatin remodeling;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Data;DNA;Enabling Factors;Enhancers;Enzymes;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;GATA3 gene;Gene Activation;Genetic Markers;Genome;genomic data;Genomic DNA;genomic locus;Goals;Grant;Higher Order Chromatin Structure;Histones;Human;human disease;Human Genome;induced pluripotent stem cell;insight;Knock-out;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;MDA MB 231;Mediating;Mesenchymal;Methods;Modeling;Molecular;Molecular Conformation;Mutation;novel;novel strategies;Nucleosomes;Positioning Attribute;predictive modeling;prevent;Process;programs;Proteins;Resolution;Role;Site;SMARCA4 gene;Structure;System;Techniques;Therapeutic;Thinness;Transcript;transcription factor;triple-negative invasive breast carcinoma

PROJECT_TITLE: Role of nucleosome architecture in cellular reprogramming

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: BALTIMORE

ORG_DEPT: CHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The activation of dioxygen by heme and nonheme metalloenzymes plays a critical role in many fundamental biological processes, including biosynthesis, detoxification, metabolic processes, and energy transfer, all of which directly or indirectly impact human health. The proposed studies focus on the synthesis and reactivity of small-molecule analogs of metalloenzyme active sites that process and manipulate various forms of oxygen. These efforts will provide fundamental knowledge relating to enzyme mechanisms which are implicated in a variety of diseases, including arthritis, cancer, genetic and neurodegenerative disorders.

PI_NAMEs: GOLDBERG, DAVID P (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Active Sites;Address;adduct;Anabolism;analog;Arthritis;Biological Process;Biomimetics;Chemistry;Complex;Cysteine dioxygenase;Cytochrome P450;Diagnostic;Dioxygen;Dioxygenases;Disease;Drug Metabolic Detoxication;electronic structure;Electronics;Encephalopathies;Energy Transfer;enzyme mechanism;Enzymes;Event;Genetic Diseases;Health;Heme;Human;Hydrogen Bonding;Hydroxylation;indoleamine;Indoles;Iron;isopenicillin N;Kinetics;Knowledge;Ligands;Malignant Neoplasms;Mediating;Metabolism;metal complex;metalloenzyme;Metals;Methodology;Mixed Function Oxygenases;Modification;Molecular Weight;Neurodegenerative Disorders;oxidation;Oxygen;Pathway interactions;persulfides;Play;Process;Property;Proteins;Role;small molecule;Structure-Activity Relationship;Sulfhydryl Compounds;Sulfoxide;Sulfur;System;Therapeutic;Thermodynamics;Transition Elements;Tryptophan

PROJECT_TITLE: Heme and Nonheme Transition Metal Complexes, Reactivity, and Mechanism


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE (RELEVANCE) The proposed research will lead to improvements in the analysis and design of genetic studies on experimental models of human disease. Because the project focuses on statistical methodology applied to experimental model organism populations, the scientiﬁc output of the project is expected to be applicable to basic research focusing on any medical condition that can be studied in model organisms. In addition, it is expected that a subset of the developed methodologies will be applicable to human genetic data and possible such applications will be considered through interactions with collaborators.

PI_NAMEs: VALDAR, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adverse reactions;Affect;Basic Science;causal variant;Complex Genetic Trait;computerized tools;Data;design;Development;Diet;Experimental Designs;Experimental Models;fly;Genetic;Genetic Crosses;Genetic Population Study;Genetic study;Genomics;Goals;Haplotypes;Heritability;Human;human disease;Human Genetics;human model;improved;Inbred Strain;Interdisciplinary Study;Maps;Medical;Metabolic;Methodology;Methods;model organism;Modernization;multiple omics;Nature;Outcome;Output;Pathogenesis;Pharmacotherapy;Phenotype;Plants;Play;Population;Procedures;programs;Quantitative Trait Loci;Reproducibility;Research;Residual state;Resources;response;Rodent;Role;Statistical Models;study population;Technology;tool;trait;treatment response;Virus Diseases

PROJECT_TITLE: Statistical Modeling of Multiparental and Genetic Reference Populations

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Dioxins in Agent Orange (AO) and burn pits in the Middle East are associated with many types of cancer and other health problems. AO is the best studied wartime exposure in Veterans, and though AO is no longer used, it remains relevant as it persists in humans for decades. More recently, Veterans were exposed to chemicals in burn pits, which contain dioxins that may cause similar health problems. Our translational research aims to 1) use genetic and clinical data to predict the risk progression to lymphoma as well as 2) compare the clinical charts and biopsy tissues of Veterans who developed blood cancers with and without environmental exposures. We hope to determine if dioxin-induced differences in the regulation of cancer-promoting genes might be causing differences in the clinical course of exposed and unexposed Veterans. Our studies may identify actionable targets for treatment of dioxin-related lymphoid malignancies in future precision oncology clinical trials.

PI_NAMEs: MA, HELEN  (contact)

PROJECT_TERMS: Age;agent orange;Antibodies;arm;Aryl Hydrocarbon Receptor;B-Cell Lymphomas;Binding;Bioinformatics;Biological Markers;Biopsy;Blood;burn pit;cancer clinical trial;cancer type;carcinogenicity;Cessation of life;chemical carcinogen;Chemicals;Chronic;Chronic Lymphocytic Leukemia;Clinical;Clinical Data;clinical database;Clinical Trials;Clinical Trials Design;cohort;Collaborations;comparison control;Conflict (Psychology);Core Facility;CYP1A1 gene;Data;Data Correlations;Data Set;Databases;Death Rate;Detection;Development;development of lymphoid malignancy;Diagnosis;Dioxins;DNA Methylation;DNA Sequence Alteration;Enrollment;Environmental Carcinogens;Environmental Exposure;epigenetic drug;Epigenetic Process;epigenetic regulation;ESR1 gene;Estrogen Metabolism;Estrogen Receptors;Estrogens;Exhibits;Exposure to;Future;Genes;Genetic;Genetic Code;Genetic Databases;Genetic Transcription;Genomics;Half-Life;Health;Health system;Healthcare Systems;Hematologic Neoplasms;Hematopoietic Neoplasms;Herbicides;Histone Deacetylase Inhibitor;Hodgkin Disease;Hormonal;Hospitals;Human;Immunosuppression;Incidence;indexing;Indolent;Inhibition of Apoptosis;Korea;large cell Diffuse non-Hodgkin's lymphoma;Life Style;Ligands;Los Angeles;Lymphoma;Lymphomagenesis;Malignant lymphoid neoplasm;Marines;mathematical model;Mediating;Medical History;Medical Records;Methylation;Middle East;Military Personnel;Modeling;Mutation;novel;Oncogenes;Outcome;Pathologist;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Population;precision oncology;preclinical study;predicting response;predictive modeling;Probability;programs;progression risk;prospective;protective effect;Proteins;Public Health;rational design;Regulation;Research;Risk;Risk Factors;risk prediction;routine care;Sample Size;Sampling;Serum;Services;sex;Smoke;Specimen;Stains;Surveys;T-Cell Lymphoma;targeted treatment;Techniques;Testing;Tetrachlorodibenzodioxin;Tissues;Translational Research;tumor;Tumor Tissue;tumorigenesis;Up-Regulation;Validation;Veterans;Vietnam;women versus men

PROJECT_TITLE: Epigenetic Dysregulation, Genetic Mutations, And Outcomes Of Lymphoid Malignancies Related To Agent Orange And Burn Pit Exposures Compared To Unexposed Case-Matched Controls


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE Millions of individuals are blind due to corneal opacity but their vision cannot be restored with a corneal transplant due to their body's rejection of transplanted tissue or because of the inability to obtain donor tissue. Previously we developed bioengineered corneal tissues that use a patient's own adult stem cells, so that barriers to restoring corneal vision due to shortage of donor tissue or rejection can be greatly reduced. The goal of this current work is to further improve the mechanical and optical properties of these tissues and to continue translation of this technology toward the clinic by validating restoration of vision using an in vivo model.

PI_NAMEs: DU, YIQIN ;FEINBERG, ADAM WALTER (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Address;adult stem cell;Alkalies;Allogenic;Anterior;anterior chamber;Architecture;Area;Autologous;Basement membrane;Biochemical;Biomechanics;Biomedical Engineering;Biomimetics;Biopsy Specimen;Bioreactors;Blindness;Cadaver;Cell Density;Cell Separation;Cell Therapy;Cells;Clinic;Clinical;clinical translation;clinically relevant;Collagen;Cornea;Corneal edema;Corneal Endothelium;Corneal Opacity;corneal repair;Corneal Stroma;cost;Cues;Cytoskeleton;Data;density;Descemet's membrane;Development;Disease;disease model;efficacy validation;Endothelial Cells;Endothelium;Engineering;Engraftment;Evaluation;Excision;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Failure;functional restoration;Generations;Genes;Goals;Graft Rejection;Healthcare;high risk;Human;human old age (65+);human stem cell-derived;Hydration status;Immune;improved;In Vitro;in vivo;in vivo Model;indexing;Individual;Injections;Injury;innovation;Integrins;Keratoplasty;Lamellar Keratoplasty;Lifelong disability;limbal;mechanical load;Mechanics;Medical Device;Melons;Modeling;monolayer;nano;nanofabrication;Natural regeneration;novel strategies;novel therapeutic intervention;Optics;Oryctolagus cuniculus;Patients;Penetrating Keratoplasty;Persons;Procedures;Process;Productivity;Property;Proteoglycan;Pump;Qualifying;repaired;Research;scaffold;Scaffolding Protein;sight restoration;stem cell differentiation;stem cells;stromal progenitor;Structure;Surface;Technology;technology development;Thick;Tight Junctions;Tissue Donors;Tissue Engineering;Tissue Transplantation;Tissues;Translating;Translations;Transplantation;Universities;Validation;Vision;Visually Impaired Persons;Work

PROJECT_TITLE: Bioengineering Cornea with Autologous Stem Cells


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE The ability to engineer cells to detect disease-associated molecular cues and respond with a therapeutic output could furnish transformative cell-based treatment solutions for a variety of currently irremediable diseases. However, because existing approaches for engineering signal transduction pathways do not incorporate phosphorylation, and therefore do not operate according to the same design principles as native signaling networks, it is challenging to engineer, fast, precise, multi-input sensing of disease-associated molecules. We propose to address this deficit by developing a signaling pathway engineering platform that allows researchers to construct cell-based devices with custom sense-and-respond programs capable of accurately perceiving diseased tissue environments and responding via secretion of therapeutic factors.

PI_NAMEs: BASHOR, CALEB  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Anti-Inflammatory Agents;Autoimmune Diseases;Behavior;Behavioral;Cell Physiology;Cell Shape;Cell Therapy;Cells;cellular engineering;Classification;clinically relevant;Coupling;Cues;Custom;cytokine;Data;design;Detection;Development;Devices;Diagnostic;Dimerization;Discrimination;Disease;Engineering;Environment;environmental change;established cell line;Event;Excision;extracellular;flexibility;Foundations;G-Protein-Coupled Receptors;Genetic Transcription;Goals;Growth Factor;Human;Immune;improved;Infection;Inflammation;Inflammatory;Malignant Neoplasms;Mediating;Membrane;Mesenchymal Stem Cells;mesenchymal stromal cell;Modeling;Molecular;Monitor;Nervous System Disorder;next generation;non-Native;novel;Output;Pathway interactions;Patients;Phosphorylation;Phosphorylation Site;Process;programs;Proteins;Proteolysis;rapid detection;receptor;Regulation;Research Personnel;response;Safety;Scheme;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;small molecule;Specificity;Surface;synthetic biology;synthetic construct;System;Technology;technology platform;Testing;Therapeutic;Time;tissue trauma;Tissues;tool;Translations;treatment response;Work

PROJECT_TITLE: A synthetic signaling pathway engineering platform for creating precision cell-based sense-and-response devices

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


PHR: Our laboratory has discovered that the protein endothelin-1, a secreted product of prostate cancer cells, stimulates bone formation once prostate cancer cells have metastasized to bone. Bone metastasis is a painful complication of advanced prostate cancer that afflicts the male Veteran population. Agent Orange exposure, common in Vietnam Veterans, doubles the risk for prostate cancer and increases the risk of prostate cancer bone metastasis at initial diagnosis. African-Americans, who make up a higher percentage of Veterans than the general population, are also at a substantially increased risk of prostate cancer. Veterans are more likely to have other serious coexisting conditions at diagnosis resulting in more treatment-related complications. This proposal is aimed at understanding mechanisms of prostate cancer bone metastasis in order to develop superior and novel therapies aimed at reducing the pain and morbidity of advanced prostate cancer in Veterans.

PI_NAMEs: CLINES, GREGORY A (contact)

PROJECT_TERMS: abiraterone;Ablation;Acetates;Adrenal Glands;advanced prostate cancer;African American population;agent orange;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Androstenediols;Androstenedione;Animal Model;antagonist;Back;bone;Bone Development;Bone Formation Stimulation;cancer diagnosis;Castration;catalyst;Cessation of life;Clinical;Clinical Trials;comparison control;Complication;Cues;Data;dehydroepiandrosterone;Development;Diagnosis;Disease;Disease Progression;Drug Targeting;Endothelin A Receptor;Endothelin-1;enzalutamide;Enzymes;Fracture;General Population;Generations;Goals;Growth;Human;humanized mouse;Hydroxysteroid Dehydrogenases;improved;intratumoral androgen;Isoenzymes;Knock-out;Laboratories;Lesion;male;Malignant Bone Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;military veteran;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Operative Surgical Procedures;osteoblast proliferation;Osteoblasts;Osteogenesis;Osteosclerotic Lesion;Oxidoreductase;Pain;pain reduction;Pathologic;pharmacologic;prevent;prostate cancer cell;prostate cancer metastasis;prostate cancer model;prostate cancer progression;prostate cancer risk;Protein Isoforms;Proteins;Radiation therapy;Reporting;Research;Residual state;resistance mechanism;Role;SCID Mice;sham surgery;Signal Pathway;Signal Transduction;Site;skeletal;Skeleton;spinal cord compression;standard care;Stanolone;Steroids;Testing;Testosterone;Tumor Burden;Veterans;Vietnam

PROJECT_TITLE: Convergence of Endothelin-1 and Androgen Signaling in Prostate Cancer Bone Metastasis


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Homelessness;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This study is directly relevant to the National Institute on Minority Health and Health Disparities’ mission to improve health equity by reducing the burden of tobacco use, tobacco exposure, and chronic disease among racially/ethnically diverse populations living in federally subsidized housing. We will conduct a wait-list cluster randomized controlled trial of our adapted smoke-free home intervention among racially/ethnically- and linguistically-diverse populations residing in federally subsidized housing, and leverage housing staff as lay health workers to support cessation behaviors among residents. This proposal has the potential to inform development of evidence-based strategies to increase implementation of smoke-free policies and smoking cessation services that can be brought to scale in federally subsidized housing in order to reduce tobacco- related health disparities.

PI_NAMEs: VIJAYARAGHAVAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Abstinence;Adopted;Adoption;Adult;African American;African American population;Area;Asian population;attributable mortality;Behavior;bilingualism;Biochemical;Black race;California;Cardiovascular Diseases;Cause of Death;Central American;Chinese;Chronic Disease;comparison intervention;cost;cost effective;Counseling;County;Cuban;Development;Disease;Disparity;disparity reduction;effectiveness evaluation;ethnic disparity;ethnic diversity;Ethnic Origin;evidence base;follow-up;Future;General Population;Geography;Health;health disparity;health equity;health equity promotion;Healthcare;Hispanic;Hispanic Populations;Home;Homelessness;Hospitalization;Household;Housing;implementation barriers;improved;Incidence;income disparities;Intervention;Intervention Studies;Latino Population;Limited English Proficiency;Linguistics;Low income;Low Prevalence;Malignant neoplasm of lung;Malignant Neoplasms;men;Minority;Mission;Morbidity - disease rate;mortality;multi-component intervention;National Institute on Minority Health and Health Disparities;Neighborhoods;non-smoker;Pamphlets;participant enrollment;Phase;Policies;poor health outcome;Population;Population Heterogeneity;Prevalence;primary outcome;Public Health;Public Housing;Race;racial disparity;racial diversity;Randomized, Controlled Trials;reduce tobacco use;Reporting;Research;Resources;San Francisco;secondary outcome;Services;Site;Smoke-free home;smoke-free policy;Smoker;Smoking;smoking cessation;smoking prevalence;Spanish;stakeholder perspectives;Subgroup;supported housing;Tobacco;tobacco abstinence;tobacco exposure;Tobacco use;Tobacco Use Cessation;Tobacco-Related Carcinoma;Training;treatment arm;treatment as usual;U.S. Department of Housing and Urban Development;Variant;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: A smoke-free home intervention in federally subsidized housing

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Our broad research program will analyze genetic variation from multiple angles. With the help of statistical and computational approaches, we will study mechanisms of mutagenesis and the functional impact of DNA variants. We will investigate evolutionary principles underlying persistence of deleterious genetic variation and develop new statistical methods for human genetics.

PI_NAMEs: SUNYAEV, SHAMIL  (contact)

PROJECT_TERMS: Alleles;Biology;cancer genomics;Computing Methodologies;Data Set;DNA;DNA biosynthesis;DNA Repair;Elements;Evolution;Explosion;Genetic study;genetic variant;Genetic Variation;Genome;Genotype;Human;Human Genetics;Medical Genetics;Molecular;Mutagenesis;Natural Selections;Penetrance;Phenotype;Polygenic Traits;Population;programs;Rare Diseases;Research;Risk;Somatic Cell;Statistical Data Interpretation;Statistical Methods;Techniques;Variant

PROJECT_TITLE: The origin, the function and the phenotypic impact of human alleles


NIH_SPENDING_CATS: Bioengineering;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Our microbiomes, or the collections of trillions of micro-organisms that live on and within us, play important roles in our health, and when disrupted, have been implicated in human diseases including infections, allergies, cancers, diabetes, liver, kidney, heart, and neurological disorders. Recently, new technologies are enabling exploration of our microbiomes in unprecedented detail, and exciting advances have been made in developing therapies that alter the microbiome with the objective of treating diseases. I propose to build new computational tools to analyze rich microbiome datasets as well as carry out integrated biological experiments, with the goals of both providing freely available tools to the research community for increasing fundamental knowledge of how our microbiomes affect us, and for purposes of accelerating development of therapies that target the microbiome for treatment of human diseases.

PI_NAMEs: GERBER, GEORG KURT (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Acceleration;Address;Affect;Assessment tool;Bacteriophages;Biological;Biological Assay;Biological Markers;Chemical Structure;Clinic;Clostridium difficile;Collection;Communities;Complex;Computer Models;Computer software;computerized tools;Computing Methodologies;Data;Data Set;deep learning;deep learning model;design;Diabetes Mellitus;Disease;Engraftment;experimental study;Food Hypersensitivity;Gene Expression;Genes;Gnotobiotic;Goals;Health;Heart Diseases;Human;human disease;Human Microbiome;Hypersensitivity;Image;improved;Infection;Kidney Diseases;Knowledge;Liver diseases;Machine Learning;machine learning method;Malignant Neoplasms;Measurement;Microbe;microbial;microbiome;microbiome alteration;microbiome components;microbiome therapeutics;microbiota;microorganism;Modality;Modeling;multimodal data;Mus;Nervous System Disorder;new technology;novel;open source;Output;Play;Population Dynamics;Population Projection;Recurrence;Research;Role;Series;Software Tools;Speech;Statistical Models;success;targeted treatment;Technology;Testing;Therapeutic;therapy development;Time;tool;translational applications;trend;Vision

PROJECT_TITLE: Probabilistic deep learning models and integrated biological experiments for analyzing dynamic and heterogeneous microbiomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: The science proposed here takes advantage of the unique scientific opportunity created by the coronavirus pandemic, to study the interaction between a definable and time-limited risk-inducing environmental event (exposure to the virus) and genomic variation, on the occurrence of cognitive decline and Alzheimer’s disease and related dementias (ADRD) in large cohorts of older adults from underrepresented minorities in the USA and ancestral groups in Africa and South America. The leading investigators have extensive experience directing international consortia and longitudinal cohorts. We have pilot ascertainment of cognitive impairment end-points in newly recruited older adults of Amerindian ancestry. We will investigate interactions between whole-genome sequence variations and COVID-19 on the risk of cognitive decline in 4,300 individuals recruited in Texas, New York, Washington State, Ibadan (Nigeria), and Jujuy (Argentina). Participant assessments will include neurological, cognitive, imaging and blood-based biomarker evaluations using harmonized protocols and at 3 time points. Three highly integrated Projects will be supported by 4 equally integrated Cores. All projects involve integrated multidisciplinary teams within a consortium of institutions in the US, Nigeria and Argentina. Resources and study expertise will be tightly coordinated across multiple sites and Cores, and integrated to the National Institute of Aging Alzheimer’s Disease Sequencing Project and National Alzheimer’s Coordinating Center which will help ensure optimal sharing of the acquire data.

PI_NAMEs: DE ERAUSQUIN, GABRIEL ALEJANDRO (contact);GONZALEZ ALEMAN, GABRIELA ;KATZ, MINDY ;PATTERSON, THOMAS F.;SESHADRI, SUDHA

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: 2019-nCoV;Acute;Address;Admixture;Adult;Affect;Africa;African;African American;African American population;age group;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amerindian;amnestic mild cognitive impairment;Anosmia;apolipoprotein E-4;Argentina;biomarker evaluation;blood-based biomarker;Brain;Central Nervous System;cerebrovascular;Cessation of life;Chronic;Clinical;Cognitive;cohort;college;Complex;coronavirus pandemic;COVID-19;COVID-19 associated anosmia;COVID-19 severity;COVID-19 susceptibility;Data;Data Analyses;Data Collection;data management;data quality;data sharing;Dementia;design;Diet;Disease;DNA;early onset;Emotional;Ensure;Epidemiology;Event;experience;experimental study;Exposure to;follow-up;Foundations;gene environment interaction;Genetic;genetic predictors;Genetic Variation;Genome;genome sequencing;genomic variation;Genotype;Guidelines;Health;Hispanic;Hispanic Americans;human old age (65+);Image;Impaired cognition;In Vitro;Individual;Induced pluripotent stem cell derived human neuron;Infection;Inflammation;Institution;International;Knowledge;Latino Population;Long COVID;Longitudinal cohort;longitudinal course;Lung;Mediating;medical schools;Medicine;Mexican Americans;Moods;multidisciplinary;National Institute on Aging;Native Americans;Nature;Nerve Degeneration;neural;Neurocognitive;neuroimaging;Neurologic;Neurologic Symptoms;neuropsychiatric sequelae of COVID-19;neuropsychiatry;neurotoxicity;New York;Nigeria;Obesity;older adult;Olfactory Cortex;Participant;Performance;Persons;Phase;Population;post SARS-CoV-2 infection;Prevention strategy;programs;Protocols documentation;Province;Recovery;recruit;Research;Research Personnel;resilience;resilience factor;Resources;respiratory;Risk;Risk Factors;Risk Marker;risk prediction;Rural;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;Science;Secondary Prevention;Severities;Site;Smoking;South America;statistics;Symptoms;Testing;Texas;Time;Traditional Medicine;treatment strategy;Underrepresented Minority;Universities;Variant;variant of interest;Viral;Virus;Washington;whole genome

PROJECT_TITLE: Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: DE ERAUSQUIN, GABRIEL ALEJANDRO (contact)

PROJECT_TERMS: Advisory Committees;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Assessment tool;Biocompatible Materials;Biological;Biological Markers;career;Clinical;Cognitive aging;cohort;Collaborations;Committee Members;Communication;Communities;comparison group;Data;Data Collection;data collection site;data management;Data Storage and Retrieval;Development;DNA Repository;Elderly;Ensure;Environment;Ethics;Event;Exposure to;Faculty;follow-up;Genes;Genetic Variation;genomic variation;Goals;Health;Impaired cognition;Individual;Institution;Institutional Review Boards;International;Leadership;Legal;Life Style;lifestyle factors;Mediation;Medical;meetings;Mentors;Methods;National Institute on Aging;neuroimaging;older adult;operation;Outcome;outreach;Persons;Population;Preparation;programs;Progress Reports;psychosocial;Publications;Recommendation;recruit;Research;Research Activity;Research Personnel;Resource Sharing;Resources;responsible research conduct;Risk;sample collection;SARS-CoV-2 exposure;SARS-CoV-2 infection;Scientific Advances and Accomplishments;Scientific Inquiry;Services;Site;Specimen;statistics;Structure;Suggestion;symposium;Teacher Professional Development;Time Management;Underrepresented Populations;Visit;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: FOX, PETER THORNTON (contact)

PROJECT_TERMS: Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;apolipoprotein E-4;archive data;Archives;arm;biobank;Biological Markers;Blood flow;blood oxygen level dependent;Brain;Clinical;cohort;Communities;comorbidity;COVID-19;COVID-19 associated anosmia;COVID-19 survivors;COVID-19 test;Data;data acquisition;Data Analyses;data archive;data exploration;data management;data sharing;data standards;Dementia;dementia risk;Disease;Electronic Health Record;Enrollment;Evaluation;Excision;expectation;experience;follow-up;Functional Magnetic Resonance Imaging;Genetic;Genetic Variation;glucose metabolism;human old age (65+);Image;image archival system;Impaired cognition;Incidence;indexing;Individual;Infection;interest;life span;Liquid substance;Magnetic Resonance Imaging;medial temporal lobe;men;Meta-Analysis;Metabolic syndrome;Morphologic artifacts;Motion;neuroimaging;Neuronal Dysfunction;pandemic disease;Participant;Pathway interactions;Patients;Phase;Polymerase Chain Reaction;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;Prospective, cohort study;Protocols documentation;Quality Control;Recording of previous events;recruit;Research;Risk;Risk Factors;Running;Sampling;SARS-CoV-2 infection;SARS-CoV-2 positive;Serum;Severities;Site;Smoking;South Texas;statistics;Structure;Surface;Survivors;System;Testing;Visual;Woman

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Treatment of large, third degree burns presents a number of challenges including the low availability of remaining healthy skin for grafting, delayed wound closure and extended hospital stays. Although rapid closure is associated with lower mortality and less scarring, available treatments require extensive manufacturing times, delaying closure. This project seeks to improve outcomes for burn patients by developing technologies to facilitate regeneration of full-thickness skin on the patient’s body without culture, leading to rapid wound closure and reduced scarring.

PI_NAMEs: KHAN, MAHMOOD ;POWELL, HEATHER M (contact);SUPP, DOROTHY MAE

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adhesions;Allogenic;angiogenesis;Animal Model;Area;Autologous;Autologous Transplantation;Biopolymers;Burn injury;burn model;burn wound;Cell Adhesion;Cell Survival;Cells;Chemicals;Cicatrix;Collagen;Collagen Type I;Data;Dermal;Dermis;design;Development;Emerging Technologies;Engineered skin;Engraftment;Environment;Epidermal Ridges;Epidermis;Epithelium;Family suidae;functional improvement;Goals;Growth Factor;improved;improved outcome;In Situ;in vivo;Infection prevention;infection risk;keratinocyte;Lasers;Length;Length of Stay;Life;Liquid substance;manufacture;Mechanics;Modeling;mortality;mouse model;Myofibroblast;nanoparticle;Natural regeneration;new technology;novel;Nutrient;Oxygen;paracrine;Patients;Pattern;PDGFA gene;Perfusion;Platelet-Derived Growth Factor;platelet-derived growth factor BB;porcine model;Predisposition;Procedures;Proliferating;Publications;Quality of life;re-epithelialization;regenerative;Regenerative Medicine;release factor;Risk Reduction;Role;scaffold;second degree burn;Sepsis;Silk;Skin;Skin graft;skin regeneration;Speed;stemness;Surface;survival outcome;Technology;Testing;Thick;third degree burn;Tissue Donors;tongue papilla;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;Width;wound;wound closure;wound healing

PROJECT_TITLE: In Situ Skin Regeneration and Angiogenesis for Full-Thickness Burns

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: ZOZUS, MEREDITH NAHM (contact)

PROJECT_TERMS: 2019-nCoV;Admixture;African;African American population;Alzheimer's Disease;Alzheimer's disease risk;Amerindian;Biological;Biological Markers;Biostatistics Core;Books;Case Report Form;Clinical;Clinical Data;Clinical Research;Code;Cognitive;Collaborations;computer program;COVID-19;COVID-19 severity;Data;Data Analyses;Data Collection;data handling;data management;data reuse;Data Set;data sharing;data standards;Decision Making;Dementia;dementia risk;design;ethnic minority population;Evaluation;experience;Faculty;follow-up;Fostering;Funding;Genetic Variation;genome sequencing;genomic variation;Goals;Good Clinical Practice;Hispanic;human subject protection;Impaired cognition;Individual;Infection;Informatics;Information Systems;Infrastructure;International;Knowledge;Latino Population;Laws;Medical History;Metadata;Methods;Mexican Americans;Mission;Molecular;Native American Tribe;neuroimaging;Neurologic;Neuropsychology;Nigeria;older adult;Participant;Phenotype;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Practice Management;Process;programs;Protocols documentation;Regulation;Reporting;repository;Reproducibility;Research;Research Activity;Resource Sharing;Risk;sample collection;Sampling;SARS-CoV-2 infection;SARS-CoV-2 infection history;Site;South Texas;Specific qualifier value;Standardization;statistics;System;Terminology;Texas;Time;Underrepresented Minority;Urate;Vaccination;Variant;Virus;whole genome;World Health Organization

PROJECT_TITLE: Biostatistics Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: RELEVANCE TO PUBLIC HEALTH Vascular contributions to cognitive impairment and dementia (VCID) have been recognized as an important cause of clinical dementia. The goal of the MarkVCID consortium, of which the University of Southern California is a participating site, is to be perform rigorous validation of imaging and fluid-based biomarkers for small vessel VCID to be ready for large scale clinical trials to evaluate novel interventions of VCID.

PI_NAMEs: KASHANI, AMIR H;RINGMAN, JOHN M;WANG, DANNY JJ (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: African American;African American population;Angiography;Area;Biological Markers;biomarker selection;Blood;Blood capillaries;Blood specimen;blood-based biomarker;California;candidate marker;candidate validation;Categories;Caucasians;cerebrovascular reactivity;Clinical;Clinical Data;clinical research site;Clinical Trials;Cognitive;cohort;Community Outreach;Data Analyses;Data Collection;Dementia;density;design;Development;Devices;Endothelium;Enrollment;Equipment;Ethnic Population;Evaluation;exosome;Eye;Eye diseases;FDA approved;Follow-Up Studies;Goals;Growth;human subject;Image;in vivo;Inflammation;Infrastructure;Intervention;Laboratories;Latino;Latinx;Light;Liquid substance;Longitudinal cohort;Longitudinal Studies;Los Angeles;Magnetic Resonance Imaging;Minority Groups;multi-ethnic;National Institute of Neurological Disorders and Stroke;neurofilament;neuroimaging;non-invasive imaging;novel;Optical Coherence Tomography;Participant;Phase;Pilot Projects;Plasma;Population Heterogeneity;programs;Protocols documentation;Public Health;racial diversity;recruit;Research;Research Personnel;research study;Resolution;retina blood vessel structure;retinal imaging;scale up;Signal Transduction;Site;Skeleton;Universities;Validation;validation studies;vascular cognitive impairment and dementia;Water;White Matter Hyperintensity

PROJECT_TITLE: Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Drug-drug interactions (DDIs) involving oral anticoagulants can lead to serious harm. To reduce harm from these dangerous combinations, creative solutions are needed that both increase the involvement of patients and harness the power of interoperable electronic health records. The purpose of this project is to disseminate a novel approach for DDIs that enhances shared decision making by providing a visual display of the potential for harm from anticoagulants and other medications, taking into account a patient’s unique attributes.

PI_NAMEs: MALONE, DANIEL C (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Implementation of DDInteract: A Shared-decision Making Tool for Anticoagulant Drug-Drug INTERACTions

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Argentina;Autopsy;Behavioral;behavioral neurology;biobank;Biological;Biological Markers;Blood;Brain;Case Report Form;Charge;Chronic;Clinical;Clinical assessments;Clinical Data;clinical diagnostics;clinical research site;Cognitive;cohort;Consensus;Consent;COVID-19;COVID-19 pandemic;COVID-19 point of care;Data;data acquisition;Data Collection;data collection site;data exchange;data management;Data Set;Databases;Dementia;Diagnosis;Diagnostic;Disease;DNA;DNA purification;Enrollment;Ensure;Epidemiology;Etiology;Evaluation;experience;follow-up;Frontotemporal Dementia;Future;Genetic Variation;genome sequencing;genomic variation;Goals;Image;Impaired cognition;impression;informant;Informed Consent;International;Interview;Language;Lewy Body Dementia;Magnetic Resonance Imaging;Medical;Methods;mild cognitive impairment;Mission;mixed dementia;neuroimaging;Neurologic;Neurologic Examination;neuropathology;neuropsychiatric sequelae of COVID-19;neuropsychiatry;Neuropsychology;Nigeria;older adult;Outcome;Participant;Pathologic;Periodicals;Persons;Plasma;Population;Positron-Emission Tomography;Procedures;Process;Protocols documentation;Recording of previous events;Recovery;recruit;Reporting;research clinical testing;Research Project Grants;Risk;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 infection;Schedule;Site;Specimen;Standardization;statistics;Structure;symposium;Syndrome;System;Tablets;Techniques;Testing;Texas;Time;Training;Vascular Dementia;Visit;Washington;Whole Blood;whole genome;World Health Organization

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Equipping parents with skills-based strategies to protect children will fill a large gap in primary child sexual abuse (CSA) prevention efforts. Smart Parents – Safe and Healthy Kids (Smart Parents) is a parent-focused, CSA-specific, skills-based module that can be added in a single session to evidence-based parent education (PE) programs used by state-supported parent service agencies across the U.S., including Parents as Teachers. Moreover, by leveraging existing PE implementation infrastructures well-supported by federal funds (i.e., Family First Prevention Services Act), the sustainability and scalability of Smart Parents is greatly enhanced, thereby maximizing the potential for public health impact and a move toward the reduction of rates of CSA.

PI_NAMEs: GUASTAFERRO, KATELYN  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age;Attitude;Awareness;Behavior;Behavior Therapy;Behavioral;Biological Models;biopsychosocial;boys;career;Child;Child Abuse and Neglect;Child Behavior;Child Development;Child Rearing;Child Sexual Abuse;Child Welfare;Clinical Trials;Cluster randomized trial;Communication;Communities;community intervention;Cost Analysis;cost effective;Cues;design;Development;Dissemination and Implementation;Economic Burden;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation trial;Enrollment;Environment;evidence base;experience;Experimental Designs;Family;family support;federal policy;Female;Focus Groups;follow-up;foster child;Foundational Skills;Funding;Future;General Population;girls;Grooming;Health;hybrid type 2 design;implementation context;implementation determinants;implementation efforts;implementation science;Individual;Infrastructure;innovation;Intention;Intervention;Interview;Knowledge;Learning Skill;male;Monitor;parent-child communication;Parenting Education;parenting intervention;Parents;physical abuse;Positioning Attribute;post intervention;Prevalence;Prevention;Prevention approach;prevention service;Prevention strategy;Primary Prevention;programs;protective behavior;Provider;Public Health;randomized, clinical trials;Research;Risk Factors;Safety;Sampling;scale up;School-Age Population;Schools;Science;Scientist;service providers;Services;Sex Behavior;Sexual Development;skills;skills training;Structure;Supervision;System;teacher;Testing;treatment as usual

PROJECT_TITLE: Parent-focused primary prevention of child sexual abuse: An Effectiveness-Implementation Hybrid Trial

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Racial and Ethnic Minority Health Research

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;acute symptom;Address;Admission activity;Admixture;Adult;Affect;African;African American population;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ambulatory Care;Amerindian;amnestic mild cognitive impairment;Anosmia;arm;Biological Markers;Biological Process;Caring;Chronic;Clinical;Cognitive;cognitive change;Complex;COVID-19;COVID-19 severity;COVID-19 survivors;Data;deep learning;Dementia;design;Dimensions;Disease;DNA sequencing;Emotional;Enrollment;Epidemiology;follow-up;Genetic;Genetic Variation;Genome;genomic variation;Guidelines;high risk;Hispanic;Hospitalization;hyposmia;Impaired cognition;Individual;Infection;Influenza;Intensive Care;International;Latino Population;Long COVID;long-term sequelae;longitudinal course;Mechanical ventilation;Medical;Mexican Americans;Moods;Morbidity - disease rate;mortality;Native Americans;Natural History;Nature;Neurocognitive;neuroimaging;Nigeria;novel coronavirus;older adult;Older Population;Olfactory Cortex;Outcome;Patients;Performance;Peripheral;Persons;Phase;Population;post SARS-CoV-2 infection;post-COVID-19;precision medicine;Publishing;Recording of previous events;Recovery;Reporting;Research Personnel;resilience factor;Risk;SARS-CoV-2 exposure;SARS-CoV-2 infection;segregation;Seroprevalences;Severities;Site;Symptoms;Syndrome;Texas;whole genome

PROJECT_TITLE: Longitudinal Epidemiology


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PI_NAMEs: GRABOCKA, ELDA  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acids;Allografting;Awareness;cancer diagnosis;Cancer Etiology;cancer risk;Cells;Cessation of life;Chemoprevention;Chemopreventive Agent;coping mechanism;Data;Death Rate;Development;Diet;Esters;experimental study;fitness;Genetic;Goals;Growth;Growth Factor;Growth Factor Receptors;Human;In Vitro;in vivo;Incidence;Inflammatory;Insulin;insulin mediators;Intraepithelial Neoplasia;KRAS2 gene;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;mortality;mouse model;mutant;novel;Obese Mice;Obesity;Obesity associated cancer;obesity development;obesity prevention;Organelles;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pandemic disease;Pathway interactions;Play;Prevention strategy;recruit;Resistance;Risk;Risk Factors;Role;Signal Transduction;STAT protein;statistics;Stress;Stress and Coping;stress granule;Terpenes;Testing;Time;transcription factor;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Stress adaptation in obesity-associated pancreatic cancer


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Infectious Diseases;Liver Disease;Microbiome;Neurosciences;Nutrition;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative This proposal provides the basis for a better understanding of the mechanisms for alcohol-induced intestinal fucosylation and barrier function in the development of ALD and may lead to the identification of novel therapeutic targets.

PI_NAMEs: DENG, ZHONG-BIN  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: adherent junction;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol prevention;alcohol response;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Anti-Inflammatory Agents;antimicrobial;Attenuated;Bacteria;Bifidobacterium;Binding;circadian regulation;commensal bacteria;Communication Tools;comparative efficacy;cytokine;Cytolysins;Data;design;Development;dietary;efficacy evaluation;Endotoxins;Enterococcus faecalis;Epithelial Cells;Epithelium;Fatty Liver;Fermentation;food consumption;Fucose;Fucosidase;Fucosyltransferase;Functional disorder;gastrointestinal epithelium;Glycoconjugates;Glycopeptides;Glycoproteins;glycosylation;Goblet Cells;Growth;gut inflammation;gut microbiota;Immune system;Immune Tolerance;Inflammation;interleukin-22;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;Knockout Mice;Ligands;Liver diseases;liver injury;loss of function;Lymphoid Cell;Mediating;Membrane;metabolomics;Microbe;microbial;microbial host;microbiome;microbiota;Mucous body substance;Mucous Membrane;Mucus-Secreting Cell;Mus;Neurons;Neuropeptides;new therapeutic target;novel strategies;Oral;Pathogenesis;pathogenic bacteria;Pathologic;Penetration;Peptides;Play;Polysaccharides;prebiotics;prevent;probiotic supplementation;Probiotics;Production;Propionates;Propylene Glycols;Receptor Signaling;Recombinants;response;Role;Secretor blood group alpha-2-fucosyltransferase;Shapes;Signal Transduction;stool sample;Stress;Supplementation;symbiont;Symbiosis;Therapeutic Intervention;Tight Junctions;Toll-like receptors;Vasoactive Intestinal Peptide Receptors;Volatile Fatty Acids;Work

PROJECT_TITLE: Characterization of the role of neuropeptide VIP-mediated fucosylation in alcohol associated liver disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Racial and Ethnic Minority Health Research

PI_NAMEs: BLANGERO, JOHN  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;Adult;African;African American population;Age;Age Years;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amerindian;Anosmia;Argentina;Biological;blood-based biomarker;brain based;Caucasians;Cause of Death;Child;China;Cities;cohort;Complex;COVID-19;COVID-19 impact;COVID-19 morbidity;COVID-19 mortality;COVID-19 patient;Data;Dementia;dementia risk;design;Disease;Encephalopathies;endophenotype;Environmental Risk Factor;Ethnic Origin;Etiology;experience;Fostering;Future;Gene Expression;Gene Frequency;Genes;Genetic;genetic architecture;genetic epidemiology;Genetic Variation;genome-wide;Genotype;health care service utilization;Heritability;high risk;human old age (65+);Hypoxic-Ischemic Brain Injury;identity by descent;Impaired cognition;improved;Individual;Infection;insight;inter-individual variation;Joints;Measures;Methods;Mexican Americans;Modeling;Morbidity - disease rate;mortality;Native Americans;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurobiology;Neurocognitive;neuroimaging;Neurologic;Neurons;Neuropathy;neuropsychiatry;older adult;pandemic disease;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phenotype;Pneumonia;Population;Population Heterogeneity;Predisposition;Prevalence;Proteins;Public Health;Puerto Rican;Recording of previous events;response;Risk;SARS-CoV-2 infection;South American;Stroke;Symptoms;Testing;Time;Variant;whole genome

PROJECT_TITLE: GXI Interactions


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The proposed research is relevant to public health because electrostatic field effects and multinuclear active sites are thought to be critical to the ways in which metalloenzymes function. An improved understanding of these factors is expected to lead to new classes of drug inhibitors, insight into the genetic origin of diseases, and new biotechnological catalysts. Thus, the research is relevant to the part of NIH’s mission pertaining to developing fundamental knowledge that will help to elucidate the mechanisms by which enzymes function.

PI_NAMEs: TOMSON, NEIL CARLETON (contact)

PROJECT_TERMS: absorption;Active Sites;Binding;Binding Sites;Biology;Biomimetics;Biotechnology;catalyst;Chemistry;Complex;computer studies;Copper;Coupled;Data;density;Development;Disease;electric field;Electron Transport;electronic structure;Electrostatics;Enzymatic Biochemistry;Enzymes;expectation;Genetic;Geometry;Goals;Heme;improved;inhibitor;insight;Investigation;Ions;Knowledge;Laboratories;Ligands;Lipoxygenase;Location;Metabolism;metal complex;metalloenzyme;Metals;Mission;Modeling;Modernization;Molecular;Mononuclear;Nitrogenase;novel drug class;novel strategies;Nuclear;Pathway interactions;photosystem II;Play;Positioning Attribute;Process;programs;Proteins;Protons;Public Health;Research;Roentgen Rays;Role;sample fixation;Site;small molecule;Spectrum Analysis;Structure;System;theories;Transition Elements;trend;United States National Institutes of Health;Work

PROJECT_TITLE: Modeling Modern Concepts in Metalloenzyme Active Site Reactivity


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Circadian clocks rely on precisely timed creation and destruction of clock proteins to communicate environmental signals and achieve 24-hour periodicity. We propose to understand how protein degradation impacts daily and seasonal timing mechanisms in eukaryotes.

PI_NAMEs: GENDRON, JOSHUA MARTIN (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Arabidopsis;Award;Biological Models;Biological Process;Biology;circadian pacemaker;Clock protein;Communication;day length;Environment;Eukaryota;Family;Feedback;Functional disorder;Funding;Future;Genetic Transcription;Goals;Hour;Human;human disease;Investigation;Laboratories;Logic;Measurement;Measures;Mediating;Molecular;Mood Disorders;National Institute of General Medical Sciences;Organism;Output;Periodicity;Photoperiod;Physiology;Plants;Prevalence;Process;protein degradation;Research;Seasons;Signal Transduction;System;ubiquitin-protein ligase;Work

PROJECT_TITLE: Protein degradation mechanisms that regulate daily and seasonal timing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PROJECT_TERMS: Acute;Age Years;Alzheimer's Disease;Archives;Atrophic;Biological Markers;Blood flow;Brain Diseases;Characteristics;Chronic;Clinical;Clinical Course of Disease;Cognitive;cohort;comorbidity;COVID-19;COVID-19 survivors;Data;data acquisition;Data Analyses;data management;data standards;demented;Dementia;dementia risk;Disease;Electronic Health Record;endophenotype;Enrollment;Equation;Evaluation;Exhibits;experience;follow-up;Functional Magnetic Resonance Imaging;Genetic;Genetic Variation;Glucose;Goals;gray matter;healthy aging;Hypertrophy;Image;Immune;Impaired cognition;Impairment;independent component analysis;Individual;Infection;Investments;Lesion;Liquid substance;Magnetic Resonance Imaging;Measures;Mediating;men;metabolic rate;Metabolic syndrome;Modeling;multimodal neuroimaging;multimodality;neural;neural patterning;neuroimaging;non-demented;pandemic disease;Participant;Pattern;Persons;Phase;Physiological;Population;Positron-Emission Tomography;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Prospective, cohort study;Quality Control;Recording of previous events;recruit;Reporting;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Risk;Sampling;SARS-CoV-2 infection;Series;Serum;Severities;Site;statistics;Surface;Survivors;Symptoms;Testing;Texas;Time;Validation;Variant;white matter;Woman

PROJECT_TITLE: Imaging Predictors


PHR: Project Narrative Once diagnosed with lung cancer, a patient typically undergoes diagnostic bronchoscopy and/or therapeutic surgery. These procedures carry a 40% failure rate due to missed tumors, positive margins, un-identified lymph nodes, and synchronous cancers. Our Project will address this problem using near- infrared optical imaging technology.

PI_NAMEs: SINGHAL, SUNIL  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Achievement;Affect;American;Attention;bench to bedside;Biopsy;Bronchoscopes;Bronchoscopy;Cancer Patient;cancer surgery;Clinical;clinical translation;Clinical Trials;Complex;Computer software;Contrast Media;Data;data management;design;Development;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Dyes;efficacy trial;Endoscopes;Endoscopy;Equipment;Excision;experience;Faculty;Failure;first-in-human;flexibility;Goals;Goggles;Grant;Healthcare;human imaging;Image;Image-Guided Surgery;Imaging Device;imaging platform;Imaging technology;improved;improved outcome;Individual;innovation;Joints;Lead;Libraries;Life;Light;Lung nodule;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Methodology;Molecular;molecular imaging;Molecular Target;Near-infrared optical imaging;neoplastic cell;Nodule;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;optical imaging;Optics;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Polyps;Procedures;programs;Protocols documentation;Publications;Research;Robotics;Science;skills;small molecule;Staging;standard of care;success;surgery outcome;Technology;Testing;Therapeutic;Therapeutic procedure;Tracer;Translating;tumor;tumor microenvironment;United States National Institutes of Health;Validation;wearable device;Work

PROJECT_TITLE: Intraoperative Near Infrared Molecular Imaging of Lung Cancer


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer

PHR: Project Narrative This grant application develops new and innovative technologies for applications in lung cancer bronchoscopy and surgery. The main goal is to aid the clinician in delineating tumor margins, identifying diseased lymph nodes and micrometastases, and determining if the tumor has been completely resected. A cocktail of innovative targeted optical contrast agents for lung cancer is expected to generate a major impact in the diagnosis and treatment of this disease.

PROJECT_TERMS: Acceleration;Address;Adjuvant Therapy;American;Applications Grants;Back;Binding;Biopsy;body cavity;Bronchoscopy;cancer cell;Cancer Patient;cancer surgery;Cancerous;capsule;Cells;Clinic;Clinical;clinical application;Clinical Trials;Colonoscopy;Colposcopy;Contrast Media;Cystoscopy;Deposition;Detection;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Dose;draining lymph node;Endoscopy;Equipment;Esophagoscopy;Excision;experience;first-in-human;flexibility;FOLR1 gene;Genomics;Goals;Grant;healthy volunteer;Histologic;Histology;Human;Image;image guided;Image-Guided Surgery;Imaging Device;improved;Individual;Infusion procedures;innovation;innovative technologies;Institution;Laparoscopy;Lesion;Localized Disease;Location;Lung;Lung nodule;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Imaging;Micrometastasis;molecular imaging;Motion;Near-infrared optical imaging;new technology;Nodule;Non-Small-Cell Lung Carcinoma;novel;Operating Rooms;operation;Operative Surgical Procedures;optical imaging;Optics;Pathologic;Patient imaging;Patients;Penetration;Pennsylvania;Phase;Polyps;Predictive Value;Procedures;Pulmonary Pathology;radiological imaging;receptor;Resectable;Resected;Residual Cancers;Residual state;Resolution;respiratory;Second Primary Cancers;Series;Solid Neoplasm;Specificity;Specimen;Staging;standard of care;success;Surgeon;Technology;Testing;Therapeutic;Thoracic Surgical Procedures;Time;Tissues;Tracer;Translating;Translations;tumor;Universities;Validation;Visual;Work;wound bed

PROJECT_TITLE: Project 1: Clinical Trials in Intraoperative Molecular Imaging of Non-Small Cell Cancer


PHR: Project Narrative This grant application develops a combination of four optical contrast agents that can be used to visually image lung cancer cells during lung cancer procedures. All prior attempts at intraoperative imaging of lung cancer have been limited to imaging a single target. This proposal will broaden this approach by creating a library of tracers that can be utilized to visualize a host of targets on lung cancer.

PI_NAMEs: LOW, PHILIP STEWART (contact)

PROJECT_TERMS: Acceleration;Address;Adenocarcinoma;Animal Hospitals;Animal Model;Antigens;Applications Grants;biomaterial compatibility;Biopsy;Bronchoscopy;cancer cell;Cancer Etiology;cancer imaging;Cancer Model;Cancer Patient;cancer surgery;cancer type;Cancerous;Canis familiaris;carbonate dehydratase;Cessation of life;chemical synthesis;Clinic;Clinical;clinical application;Clinical Trials;Colon Carcinoma;Contrast Media;Data;Detection;Development;Disease;Dose;Drug Kinetics;Dyes;efficacy testing;Ensure;environmental tobacco smoke exposure;experience;experimental study;fibroblast-activating factor;Fibroblasts;Fluorescence;Fluorochrome;folate-binding protein;FOLH1 gene;Folic Acid;FOLR1 gene;Formulation;Genetic Heterogeneity;Goals;Grant;Human;human model;Image;image guided;Image-Guided Surgery;improved;In Vitro;innovation;Institution;Intervention;Libraries;Logistics;lung cancer cell;lung imaging;lymph nodes;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane;Molecular;molecular imaging;Molecular Probes;mouse model;Mus;near infrared dye;Nodule;Noise;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Optics;Pathologic;Patient Agents;Patients;Persons;phase 2 study;Phenotype;Population;pre-clinical;pre-Investigational New Drug meeting;Procedures;programs;receptor;Reproducibility;Research;Second Primary Cancers;Sensitivity and Specificity;success;targeted agent;Testing;Time;Tissues;Tracer;Translations;tumor;United States;Visual;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Project 2: Near-Infrared Targeted Tracers for Intraoperative Identification of NSCLC


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The proposed research aims to integrate advanced spectroscopic instrumentation, pixel-level chip design, flexible robotic manipulation, and clinically applicable targeted tracers for image-guided biopsy and surgery of lung tumors under minimally invasive conditions.

PI_NAMEs: NIE, SHUMING  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Anatomy;Architecture;Attention;Augmented Reality;biological systems;Biomedical Engineering;Biopsy Specimen;Bronchoscopes;Bronchoscopy;cancer cell;cancer imaging;Clinical;clinical application;clinical translation;Clinical Trials;Collaborations;Colonoscopy;Color;compound eye;Custom;Data;Dedications;Deposition;design;Detection;detection sensitivity;Development;Devices;Diagnosis;Diagnostic Procedure;Distal;Electrons;Elements;Engineering;ergonomics;Feedback;Fingers;first-in-human;flexibility;Fluorescence;fluorescence imaging;Generations;Goals;Goggles;Hand;hologram;Holography;Human;Image;Image Guided Biopsy;image reconstruction;Imaging Device;imaging system;improved;in vivo;Individual;Industrialization;industry partner;innovative technologies;instrumentation;Lesion;Libraries;Light;Localized Lesion;Location;lung lesion;Lung Neoplasms;Lung nodule;lymph nodes;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;mantis shrimp;Medical;metal oxide;miniaturize;miniaturized device;minimally invasive;mixed reality;Molecular;molecular imaging;Molecular Probes;Near-infrared optical imaging;new technology;Nodule;Noise;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Optics;Patient Care;Patients;Procedures;programs;Research;Research Personnel;Risk;Robot;Robotics;Semiconductors;Sensitivity and Specificity;sensor;Sensory;Software Engineering;spectrograph;Surgeon;Surgical incisions;System;Tactile;Technology;technology development;Temperature;Testing;three-dimensional visualization;Time;Tissues;Tracer;Translating;tumor;Tumor Antigens;Visual System;Visualization;wearable device;Work

PROJECT_TITLE: Project 3: Multispectral Imaging and Robotic Bronchoscopy Devices for Precision Lung Tumor Detection


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The rapid pace of discovery about breast cancer biology has given rise to survival gains and new precision screening and treatment approaches. The overarching goal of our application is to use collaborative computer modeling to inform translation of precision oncology evidence to clinical guidelines and policy by evaluating strategies to further decrease mortality, understand survivor quality of life, and reduce disparities. We will use six breast cancer simulation models as a virtual laboratory to inform policy and clinical decisions by evaluating the impacts on mortality, quality of life, harms, and costs of disseminating these evolving precision cancer control paradigms.

PI_NAMEs: ALAGOZ, OGUZHAN ;DE KONING, HARRY J;HUANG, XUELIN ;LEE, SANDRA J;MANDELBLATT, JEANNE ;PLEVRITIS, SYLVIA KATINA;STOUT, NATASHA KAY;TRENTHAM-DIETZ, AMY  (contact);VAN RAVESTEYN, NICOLIEN

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Accounting;Address;Adjusted Life Years;Adjuvant;Adverse effects;Affect;Age;American Cancer Society;American College of Radiology;American Society of Clinical Oncology;Area;Basic Science;Benchmarking;Benign;Biological Markers;Biopsy;Black race;Breast;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;Breast Cancer therapy;breast density;breast imaging;Cancer Biology;cancer care;Cancer Control;Cancer Intervention and Surveillance Modeling Network;Cardiomyopathies;career;career development;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic;Chronic Disease;circulating biomarkers;Clinical;clinically relevant;Collaborations;comorbidity;comparative;Complex;Computer Models;cost;density;Diabetes Mellitus;Diagnosis;Disease;Disease-Free Survival;disorder risk;disparity reduction;Distant;Environment;Equilibrium;experience;flexibility;Fostering;Funding;Future;Goals;Guidelines;Health Policy;Hematologic Neoplasms;improved;Incidence;Infrastructure;innovation;Intervention;Investigation;liquid biopsy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Mentors;Modality;Modeling;models and simulation;Modernization;molecular subtypes;mortality;mortality disparity;Natural History;Neoadjuvant Therapy;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Outcome;outcome disparities;Paper;Performance;personalized approach;personalized screening;Policies;policy recommendation;Positioning Attribute;precision oncology;Precision therapeutics;primary outcome;programs;Public Health;Publishing;Quality of life;Quality-Adjusted Life Years;Race;racial disparity;Recording of previous events;Records;Recurrence;Registries;Research;Research Personnel;Resource Sharing;Resources;response;Risk;Risk Factors;screening;Second Primary Cancers;Structure;Survivors;synergism;technological innovation;Technology;Testing;Training;translational oncology;Translations;trend;United States Preventative Services Task Force;Variant;virtual laboratory;White Women;Wisconsin;Woman;Work;working group

PROJECT_TITLE: Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Biotechnology;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Bridges to Baccalaureate students would be recruited and provided educational readiness by Prison to Professionals while still incarcerated, transition to a 2-year associates granting school (Baltimore City Community College, BCCC), be provided skills and methods development during their 2-years at BCCC, participate in a 10-week STEM research internship at Howard (HU) University, then transition to a 4-year Bachelors granting school, HU. Thus, this project is taking the highly innovative approach to intersect the worlds of research, education, and incarceration by creating a ground-breaking prison-to-college-and-STEM pipeline.

PI_NAMEs: ANDRISSE, STANLEY  (contact);MALAKI, ANIL ;SKUDRZYK, BASIA HELEN

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Associate Degree;Back;Baltimore;Biology;Biotechnology;bridge to the baccalaureate;Cities;cohort;Collaborations;college;community college;community organizations;Creativeness;Development;Education;Educational Curriculum;Educational workshop;experience;frontier;Funding;gateway course;Goals;Government;Grant;Hip region structure;Imprisonment;Incentives;Individual;innovation;instrumentation;interdisciplinary approach;Internships;Lead;Leadership;Medicine;meetings;men;Mentors;method development;Methods;Molecular;Participant;people of color;Persons;Population;Prisons;Process;programs;Radio;Readiness;recruit;Research;Research Personnel;Research Training;Running;Scholarship;Schools;Science;skill acquisition;STEM research;Students;supplemental instruction;synergism;Talents;Techniques;Time;Training Programs;Universities;Woman;Work

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at Howard University and Baltimore City Community College

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


PHR: Project Narrative The goals of the Administrative core will be coordinate effective interactions among projects, cores, oversight committees; provide Data safety and Monitoring support; ensure clinical trials are under the highest standards of “Good Clinical Practices”; and, provide budget support.

PROJECT_TERMS: Advisory Committees;Budgets;Cancer Center;Clinical Trials;Communication;Communities;continuing medical education;Data;Ensure;Expenditure;experience;Funding;Goals;Good Clinical Practice;Grant;high standard;Image;Industrialization;Industry;Malignant neoplasm of lung;meetings;molecular imaging;Monitor;Newsletter;Operative Surgical Procedures;optical imaging;Participant;programs;Regulation;Reporting;Research Personnel;Resource Sharing;Safety;Specialist;Structure;Universities

PROJECT_TITLE: Shared Resource - Core A: Administrative Core


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative Core C (Biostatistics and Data Management) will provide expert guidance and collaboration in the biostatistical and data management aspects of the design, conduct and analysis of translational research projects generated by this program project application.

PI_NAMEs: HWANG, WEI-TING  (contact)

PROJECT_TERMS: Address;Adherence;anti-cancer research;Basic Science;Biomedical Research;Biometry;Biostatistics Core;Canis familiaris;Case Report Form;Clinical;Clinical Trials;Clinical Trials Database;Collaborations;Consult;Data;Data Analyses;data management;Data Management Resources;data quality;data sharing;design;experience;Goals;Graph;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Manuscripts;member;molecular imaging;Monitor;Monitoring Clinical Trials;Population;Preparation;Procedures;programs;Qualifying;Quality Control;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;Safety;Sample Size;Services;Statistical Data Interpretation;Statistical Methods;Translational Research;Work

PROJECT_TITLE: Biostatistics and Data Management Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The goal of this proposed program is to develop an end-user informed HIV pre-exposure prophylaxis (PrEP) technology as an Acceptable Multi-user Biodegradable Extended Release (AMBER) implant. The AMBER implant offers the following beneficial features for delivery of novel PrEP agents: user independence, long-term protection (≤1 year), and discretion of use, biodegradation, and retrievability, if needed, for the duration of drug delivery.

PI_NAMEs: JOHNSON, LEAH  (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Address;Adherence;Adverse reactions;African American;AIDS prevention;Alabama;Animal Model;Anti-Retroviral Agents;Anti-viral Agents;Area;Behavioral Research;biodegradable polymer;Biodegradation;Bypass;California;Centers for Disease Control and Prevention (U.S.);Characteristics;cis-female;clinical translation;copolymer;design;Development;Devices;dosage;Dose;Drug Delivery Systems;Drug Formulations;Drug Kinetics;drug release kinetics;efficacy evaluation;Engineering;Epidemic;Ethnic Origin;Excision;experimental study;exposure route;Exposure to;fabrication;Focus Groups;forgetting;Formulation;Future;Gender;gender diverse;Geographic Locations;Geography;Goals;HIV;Implant;improved;In Vitro;in vivo;in vivo Model;industry partner;informant;inhibitor;Injectable;innovation;insight;Integrase Inhibitors;International;Intervention;Interview;Kinetics;Latino;Lead;manufacturing process;mechanical properties;Mechanics;Medical;Medicine;men who have sex with men;Modeling;Modification;Mucous Membrane;multidisciplinary;nonhuman primate;novel;Nucleosides;Online Systems;Pattern;penis;Pharmaceutical Preparations;Pharmacologic Substance;Polymers;Population;pre-exposure prophylaxis;preclinical study;preference;product development;programs;Property;prototype;Public Health;racial minority population;Rectum;Research;Research Institute;Risk;RNA-Directed DNA Polymerase;Safety;safety study;San Francisco;Science;Sex Orientation;Social Behavior;subcutaneous;success;Surveys;System;Tail;Technology;technology development;Toxic effect;transgender women;Trocars;United States;United States National Institutes of Health;Universities;Vagina;Woman;young men who have sex with men

PROJECT_TITLE: Acceptable Multi-user Biodegradable Extended Release (AMBER) Implant System for HIV Prevention


PHR: Project Narrative The Imaging Core (Core B) provides state-of-the-art imaging facilities to the Projects in this application. Our focus is on the development and implementation of imaging protocols for fluorescence imaging of tumors in situ, calibration and testing of new imaging systems, and the development of back table imaging protocols to aid in the detection of tumor margins, micrometastases and cancerous lymph nodes. Core B also supports both large animal (canine) and small animal (mouse) imaging to facilitate translation of the cocktail of imaging agents into surgical applications in patients with pulmonary cancers.

PI_NAMEs: DELIKATNY, EDWARD J (contact)

PROJECT_TERMS: animal imaging;Animals;Antigens;Back;Benchmarking;Biodistribution;Biopsy;Biopsy Specimen;Bronchoscopy;Calibration;cancer clinical trial;cancer imaging;Cancer Patient;Cancerous;Canis familiaris;carbonate dehydratase;Carcinoma in Situ;Clinic;Clinical;clinical imaging;Clinical Trials;Communities;computerized data processing;Contrast Media;Data;Data Analyses;Data Collection;Dedications;Deposition;design;Detection;Development;Devices;Diagnostic;digital pathology;Drug Kinetics;Dyes;Equipment;ex vivo imaging;Excision;Faculty;fibroblast-activating factor;Fibroblasts;Fluorescence;fluorescence imaging;Goals;Histopathology;Human;human imaging;Image;Image-Guided Surgery;imaging agent;imaging facilities;imaging platform;imaging study;imaging system;improved;In Situ;instrumentation;Location;Lung;Lung Neoplasms;lymph node biopsy;Lymph Node Dissections;lymph nodes;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;medical schools;Methods;Micrometastasis;Microscope;Microscopic;microscopic imaging;Microscopy;Mission;Modeling;molecular imaging;Mus;Near-infrared optical imaging;Neoplasm Metastasis;Nodule;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Optical Biopsy;optical imaging;Optics;Outcome;Pathology;Patients;pre-clinical;preclinical imaging;Prognosis;Program Research Project Grants;programs;Protocols documentation;Radiology Specialty;Resolution;Resources;Sampling;Sensitivity and Specificity;Series;Specimen;Surgical Management;Surgical Pathology;targeted imaging;Techniques;Testing;Tissue imaging;tissue processing;Tracer;Training;Translating;Translations;tumor;tumor microenvironment;Veterinary Schools

PROJECT_TITLE: Imaging Core


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Metastasis is the major cause of mortality in human breast cancer. The mechanisms that allow tumor cells to move from the blood into the tissue at a distal site, survive and grow are of intense scientific and clinical interest. This Program Project will use novel methodologies to explore exciting new hypotheses about tumor cell behavior during the late steps of metastasis, and will have important implications for the clinical treatment of metastatic disease in breast cancer.

PI_NAMEs: BACKER, JONATHAN M. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Affect;analytical method;Animals;anti-cancer research;Area;Biology;Biosensor;Blood;Blood Platelets;Breast Cancer Cell;cell behavior;Cell Communication;Characteristics;chemotherapy;Clinical;clinical application;Clinical Treatment;Data;Disease;Distal;Environment;epithelial to mesenchymal transition;Epithelium;Event;Evolution;Extravasation;Flow Cytometry;Frequencies;Genetic study;Genetic Transcription;Growth;Human;Hypoxia;Image;imaging modality;in vivo;inducible gene expression;innovation;insight;interest;Invaded;Investigation;Lead;Link;Lung;lung colonization;lung imaging;lung metastatic;Macrophage;Malignant Breast Neoplasm;Mesenchymal;Metabolic;Metastatic Neoplasm to the Lung;metastatic process;Methodology;mortality;multiphoton microscopy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Oxidation-Reduction;paracrine;PIK3CG gene;Positioning Attribute;Primary Neoplasm;Process;programs;Proliferating;Property;reconstruction;Recording of previous events;Regulation;Reporting;Role;Signal Pathway;Signal Transduction;Site;Sorting;stem;stemness;Stress;Stromal Cells;synergism;Techniques;Testing;Time;tissue fixing;Tissues;tool;Transcriptional Regulation;tumor microenvironment;Visualization

PROJECT_TITLE: The Biology of Lung Metastasis in Breast Cancer