NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Nutrition;Patient Safety;Precision Medicine;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Hyperkalemia (a high potassium level in the blood) is a frequent electrolyte abnormality and is associated with an increased risk of death. The kidney is the primary organ for excretion of potassium from the body, but currently only the kidney's ability to filter potassium from the blood is measured; however, the secretion of potassium, which is an important mechanism for potassium elimination, is not measured. This proposal will measure novel biomarkers that reflect kidney tubule secretion and determine their association with the risk of developing hyperkalemia in a cohort of heart failure patients from the NHLBI sponsored TOPCAT study.

PI_NAMEs: WETTERSTEN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Address;Albuminuria;Aldosterone;Ancillary Study;appropriate dose;arm;Biological Markers;biomarker identification;biomarker panel;Blood;blood pressure intervention;Blood specimen;Cardiomyopathies;cardiovascular risk factor;Cessation of life;Chronic Kidney Failure;Cities;Clinical Markers;clinical practice;clinical risk;clinical trial enrollment;cohort;Creatinine;Data;design;Development;Distal;Distal convoluted renal tubule structure;Dose;Drug Interactions;EFRAC;Electrolytes;Evaluation Studies;Excretory function;Face;Fibrosis;follow-up;Frequencies;General Population;glomerular filtration;Glomerular Filtration Rate;Goals;Health;Heart Arrest;Heart failure;heart failure with reduced ejection fraction;high risk;Homeostasis;Hospitalization;hyperkalemia;improved;Incidence;Individual;individual patient;innovation;insight;International;Intervention Trial;Investigation;Kansas;Kidney;kidney biopsy;Kidney Diseases;Life;Link;Measures;Medical;Methods;Monitoring Clinical Trials;mortality risk;National Heart, Lung, and Blood Institute;Natriuretic Peptides;novel;novel marker;Organ;Participant;Patients;Pharmaceutical Preparations;Placebos;Positioning Attribute;Potassium;preservation;prospective;Questionnaires;Randomized;randomized, clinical trials;Renal tubule structure;Research;Resources;Risk;Risk Factors;risk minimization;risk mitigation;risk stratification;Serum;Spironolactone;Spottings;Subgroup;Symptoms;tool;Toxin;Tubular formation;Urine;Work

PROJECT_TITLE: Biomarkers of Kidney Secretory Function for Discriminating Risk of Hyperkalemia


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Using 3 mouse models of MDS, patient cells and iPSC models of age-related clonal hematopoiesis (ARCH) we identify a transcriptional signature comprising Nucleoporin (NUPs) family members as highly associated with MDS induction and disease transformation in patients and disease inducing in mice and human models. Our goal in is to comprehensively examine the role of the NUP pathway in the induction of MDS from aging related factors of ARCH and inflammation and identify the mechanisms of their actions.

PI_NAMEs: KOUSTENI, STAVROULA  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Abnormal Karyotype;Acute Myelocytic Leukemia;Affect;Age;Age Factors;age related;Aging;aging population;aging related;AML/MDS;Automobile Driving;beta catenin;Bone Marrow;cancer cell;cancer stem cell;CD34 gene;Cells;Chronic;Clinical;clinically relevant;Clonal Evolution;Clonal Hematopoietic Stem Cell;Clonality;cohort;conventional therapy;curative treatments;Cytogenetics;cytopenia;Development;Disease;Disease remission;DNMT3a mutation;Down-Regulation;driver mutation;Dysmyelopoietic Syndromes;Early identification;effective therapy;epigenomics;Event;Evolution;Family member;Future;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Goals;Growth;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;Human;human induced pluripotent stem cells;human model;Impairment;improved;induced pluripotent stem cell;Inflammation;Inflammatory;insight;Lead;Leukemic Hematopoietic Stem Cell;Malignant - descriptor;Modeling;Molecular;Morphology;mouse model;Mus;Mutate;Mutation;Myelogenous;Myeloproliferative disease;Nuclear;Nuclear Pore Complex Proteins;NUP98 gene;Osteoblasts;Pathogenesis;Pathway interactions;Patients;permissiveness;Population;Preleukemia;prognostic;Recurrence;Risk;Role;Sampling;Signal Transduction;Somatic Mutation;stem cells;Stress;Testing;Therapeutic;therapeutic target;transcriptomics;Translating;Transplantation

PROJECT_TITLE: Molecular Mechanisms of MDS pathogenesis with aging

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE: For the second phase of the Environmental Influences on Child Health Outcomes (ECHO-II) consortium, the Columbia Center for Children’s Environmental Health (CCCEH) proposes to use ECHO-wide core data elements and specialized protocols to determine how prenatal exposure patterns contribute to asthma and Attention Deficit Hyperactivity Disorder comorbidity. CCCEH also plans to implement the ECHO Cohort Protocol with high fidelity and proposes a plan for enhancing diverse perspectives that will be implemented while conducting all scientific aims. This proposal intends to contribute fundamental knowledge pertaining to two burdensome childhood diseases to fill current research gaps that, in turn, should help raise risk-awareness, increase referrals for assessment of comorbid disorders, and allow for earlier intervention.

PI_NAMEs: HERBSTMAN, JULIE BETH (contact);MARGOLIS, AMY ;MILLER, RACHEL L

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: 3-Dimensional;Address;Age;Air Pollution;Airway Disease;Asthma;Attention;Attention deficit hyperactivity disorder;Awareness;Biological Assay;Biological Markers;Birth;Black race;Chemical Exposure;Chemicals;Child;Child Health;Childhood;Childhood Asthma;climate change;clinical practice;cohort;Cohort Studies;Communities;comorbidity;Complex;Conceptions;Data Element;design;Development;Diagnosis;Disease;Early identification;Early Intervention;early pregnancy loss;Enrollment;Ensure;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Policy;environmental tobacco smoke;epigenomics;Etiology;Exposure to;Extrinsic asthma;Health;Hispanic;Housing;Hyperactivity;improved;Impulsivity;inattention;Incidence;Individual;Infant;Intervention;Investigation;Knowledge;Leadership;Life;Link;Manuscripts;Measures;Mendelian randomization;Modeling;Modification;multisensory;neighborhood disadvantage;Neighborhoods;neurodevelopment;Neurodevelopmental Disorder;novel;Outcome;Parents;Participant;Pathway interactions;Pattern;Pesticides;Phase;Phenotype;pilot test;Policies;Population;Populations at Risk;Pregnancy;Pregnancy loss;pregnant;prenatal;prenatal exposure;Prevalence;prevent;Prevention;Prevention strategy;Protocols documentation;pulmonary function;Questionnaires;recruit;Recurrence;Reporting;Research;respiratory;respiratory health;Risk;Role;Sampling;Science;sex;Site;skills;social;Socioeconomic Status;Structural Racism;Surveys;Testing;Time;treatment strategy;Wheezing;Writing;young adult

PROJECT_TITLE: Columbia Center for Children's Environmental Health in ECHO II: Impact of environmental exposures on children's health and the co-morbidity of asthma and ADHD.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative. Many youth are burdened with attention deficits, inattention, hyperactivity, anxiety or depressive mood, and these conditions can have long term serious consequences that impair their ability to succeed in school, obtain and keep productive jobs, get along with their peers, or find happiness. This project seeks to understand and identify some early childhood exposures, behaviors, or experiences that may increase risks for those problems, and ones that may help them avoid these issues. The public health importance of the proposed project is that finding out what changes a child’s risks or improves their outcomes can help public health agencies to design interventions to help children before the problems become severe or even before they know they are affected by these conditions.

PI_NAMEs: BENNETT, DEBORAH HALL;HERTZ-PICCIOTTO, IRVA  (contact);SCHWEITZER, JULIE B.

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Affect;Affective;Age;Air Pollution;Aliquot;Anxiety;anxiety symptoms;Area;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;autism symptoms;Behavior;Behavioral;biobank;Biological;Biological Factors;Black race;Blood;Brain;Cell Differentiation process;Characteristics;Charge;Chemical Exposure;Chemicals;Child;Child Health;Childhood;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive skill;cohort;Collection;Consultations;Data;Data Collection;data platform;depressive symptoms;Development;Developmental Delay Disorders;Diagnosis;Diagnostic Factor;diversity and equity;DNA;early childhood;Emotional;Emotions;Enrollment;Environment;Environmental Exposure;environmental justice;Environmental Risk Factor;environmental stressor;Epigenetic Process;Ethnic Origin;Ethnic Population;Evaluation;experience;Exposure to;falls;Family;Fetal health;Financial Hardship;follow-up;Funding;Goals;Green space;Happiness;Health;Health Insurance Portability and Accountability Act;high risk;Hispanic;Home;Household;Household Products;Hyperactivity;Impairment;improved;Impulsivity;inattention;indexing;Indigenous;Individual;Influentials;Infrastructure;Institutional Review Boards;Intellectual functioning disability;Intervention;Irritable Mood;Knowledge;lead exposure;Leadership;Life;Link;longitudinal design;Measures;Mental Depression;Mental Health;middle childhood;Modification;Moods;multi-racial;myelination;Neighborhoods;neurodevelopment;Neuroglia;Neurons;Neurosciences;novel;Occupations;Outcome;Outcome Measure;Paper;Parents;Participant;Pattern;Pediatric cohort;peer;Peer Review;Pesticides;Phase;phthalates;Plasticizers;Play;Policies;Poly-fluoroalkyl substances;postnatal;prenatal;Process;Productivity;prognostic;programs;Protocols documentation;Puberty;Public Health;Publications;Race;racial population;Radiation;Regulation;Research;resilience factor;Resources;retention rate;Risk;Risk Factors;Role;Schools;Science;sex;Site;SNP array;social;social factors;Social Justice;social stressor;stressor;Subgroup;substance use;Symptoms;synaptogenesis;Syndrome;System;therapy design;Time;Urine;Visit;Work;working group;Youth

PROJECT_TITLE: Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence


NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Maternal Health;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative We plan to recruit at least 2500 pregnant women, their partners, and offspring from the University of Pennsylvania and Children’s Hospital of Philadelphia as part of the nationwide ECHO Cohort to understand the role of early exposures on child health outcomes. Building on our longstanding history of successful recruitment and follow-up, we will implement the ECHO Cohort protocol with high fidelity in a population reflective of the Philadelphia community.

PI_NAMEs: BURRIS, HEATHER HERSON;DEMAURO, SARA BONAMO;MUMFORD, SUNNI L. (contact)

PROJECT_TERMS: 3 year old;adverse pregnancy outcome;Affect;Age;Air Pollution;anti-racism;Area;Asthma;Behavior;Birth;Black race;Child;Child Health;Child health equity;Childhood;Clinical Research;cohort;Collaborations;Communities;community violence;Complex;Conceptions;Couples;dashboard;Data;design;Development;Diet;Dietary Practices;Disease;disparity reduction;early childhood;Education;Endocrine;Ensure;Environment;Environmental Exposure;Environmental Health;Equity;extreme temperature;Fertility;Fetal Growth;follow-up;Green space;Growth;Guidelines;Health;health care settings;health disparity;health equity;Health Promotion;Health system;Healthcare;Immunologics;improved;Income;Individual;Inequity;Infant;Infant Mortality;Inflammatory;innovation;Institution;Intervention;Investments;Joints;Life;Life Style;Lived experience;Longterm Follow-up;Maternal and Child Health;Maternal-fetal medicine;Medicaid;Methods;Modernization;mortality disparity;multidisciplinary;Neighborhoods;Neonatology;neurodevelopment;Neurodevelopmental Deficit;novel;novel strategies;Obesity;obesity in children;offspring;Outcome;outcome disparities;Oxidative Stress;Pathway interactions;Patients;Pediatric cohort;Pediatric epidemiology;Pediatric Hospitals;Pennsylvania;Perinatal;Persons;Phenotype;Philadelphia;Physical activity;Pollution;Population Heterogeneity;Positioning Attribute;Postpartum Period;postpartum weight;Practice Guidelines;Pregnancy;pregnancy health;pregnant;Premature Birth;prevent;Protocols documentation;Psychosocial Stress;Public Health;Race;racial disparity;racism;Recording of previous events;recruit;Research;Risk;Role;Site;Sleep;social;social epidemiology;success;Targeted Research;Underrepresented Populations;Universities;Violence;walkability;wearable device;Work

PROJECT_TITLE: Penn-CHOP ECHO


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE LATE-NC (limbic-predominant age-related transactive response DNA-binding protein of 43 kDa [TDP-43] encephalopathy neuropathological change) is the third most impactful cause of dementia, but we cannot yet diagnose, treat, or prevent LATE-NC in living persons. This project seeks to define molecular and cellular signatures of LATE-NC by detailed profiling of hundreds of human brain samples, and to generate a comprehensive roadmap for model system development, diagnostic biomarker discovery, and therapeutic target identification. As LATE-NC is a common and pernicious brain disease that primarily affects the oldest old, the most rapidly growing segment of the population in the United States, this project has the potential to have an enormous public health impact.

PI_NAMEs: YANG, HYUN-SIK  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Accounting;Affect;age related;Aged, 80 and over;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amygdaloid structure;Amyloid beta-Protein;Astrocytes;Autophagocytosis;Autopsy;Binding Proteins;Biological Assay;Biological Models;biomarker discovery;biomarker identification;Brain;Brain Diseases;Brain region;candidate marker;causal model;Cell Nucleus;cell type;Cells;Cerebrovascular Disorders;Chromatin;Communities;comorbidity;Data;Dementia;Diagnosis;diagnostic biomarker;Disease;disease model;DNA-Binding Proteins;Encephalopathies;Ensure;epigenome;Event;frontal lobe;Functional disorder;Future;Gene Expression;Genes;Genetic;genetic association;Genetic Transcription;Human;human data;improved;In Vitro;in vivo;Knowledge;limbic-predominant age-related TDP-43 encephalopathy;Maps;Mediation;Membrane;Memory;Messenger RNA;Metabolism;Modeling;Molecular;Multiomic Data;multiple omics;myelination;Nerve Degeneration;neuron loss;neuropathology;older adult;Oligodendroglia;Outcome;Participant;Pathology;Pathway interactions;Patients;Persons;Population;prevent;Process;protein biomarkers;protein TDP-43;Proteins;proteomic signature;Proteomics;Public Health;Recommendation;religious order study;Repression;Research;Research Project Grants;response;risk variant;RNA;RNA metabolism;RNA-Binding Proteins;Sampling;sex;Small Nuclear RNA;Statistical Models;symposium;Synapses;Systems Development;targeted biomarker;targeted treatment;tau Proteins;Testing;therapeutic target;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transposase;United States;United States National Institutes of Health

PROJECT_TITLE: Molecular and cellular underpinnings of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC)

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Climate change is increasing the disproportionate environmental and public health impacts of disasters on marginalized communities, demanding action to address existing gaps in environmental and public health disaster research training in graduate and continuing education, and to create pathways to increase representation of trained underrepresented minority (URM) scholars. In response, the University of Washington will develop a short course, Increasing Diversity in and Equitable Access to Applied Learning in Disaster Research Response: IDEAAL DR2, led by faculty with expertise and experience conducting interdisciplinary health-related disaster research to provide such training to up to 100 scholars. We will partner with the William Averette Anderson Fund (BAF), the premiere non-profit organization dedicated to diversifying the fields of disaster and hazard research and practice, to create an inclusive recruitment strategy and provide targeted advising and financial support to URM scholars and advisors.

PI_NAMEs: ERRETT, NICOLE ANN (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Academy;Accountability;Address;Advisory Committees;Affect;Awareness;Biomedical Research;Black, Indigenous, People of Color;career;career networking;climate change;Collaborations;Communication;Communities;community engaged research;community engagement;Complex;Continuing Education;Data Science;Dedications;design;Development;Disasters;Economics;Education;Educational Curriculum;Educational workshop;Environmental Health;Epidemiology;Equipment;Equity;equity, diversity, and inclusion;Ethics;ethnic minority;Evaluation;Event;evidence base;experience;Faculty;Financial Support;Foundations;Frequencies;Funding;Goals;Graduate Education;hands-on learning;hazard;Health;Health Resources;Home;implementation science;Inequity;Institution;instrumentation;interest;Knowledge;Knowledge acquisition;Learning;learning strategy;Lived experience;marginalized community;member;National Institute of Environmental Health Sciences;Nonprofit Organizations;occupational health/safety;Paper;Pathway interactions;peer;Persons;Process;Professional Organizations;Program Evaluation;programs;Protocols documentation;Public Health;Publications;racial minority;Readiness;Recommendation;Recording of previous events;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;response;Risk;Science;skill acquisition;skills;symposium;Technology;tool;Training;Training Activity;Training Programs;Trust;Underrepresented Minority;Universities;Voice;Washington;web page;Work


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Congenital Heart Disease;Epilepsy;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SYRACUSE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: It is critical to use a clinically-relevant model and to take a multi-system approach when developing drugs to treat the pathologies associated with genetic ion channelopathies of the brain and heart. In people, KCNH2 variants are linked to a high risk of epilepsy, sudden unexpected death in epilepsy (SUDEP), arrhythmias, and Long QT Syndrome Type 2 (LQT2). As there are no established anti-seizure medications for LQT2 patients with epilepsy, we will demonstrate that our new translational model of Kcnh2-mediated epilepsy, SUDEP, and LQT2 will facilitate future neurotherapeutic discovery and testing.

PI_NAMEs: AUERBACH, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Action Potentials;Animal Model;Anticonvulsants;Arrhythmia;Biological Assay;Brain;Cardiac;Cause of Death;cell type;Cessation of life;Clinical;clinically relevant;CRISPR/Cas technology;Data;Development;Disease;Dose;Drug Modelings;drug testing;Electrocardiogram;Electroencephalography;Epilepsy;Exhibits;Face;Family member;Frameshift Mutation;Future;Genes;Genetic;genetic variant;Genotype;Goals;Heart;Heterozygote;High Prevalence;high risk;Human;in vivo;Ions;Link;Long QT Syndrome;Measures;Mediating;Membrane Potentials;Modeling;Muscle Cells;mutant;Neurons;Oryctolagus cuniculus;Outcome Measure;Pathology;patient registry;Patients;Pattern;Pentylenetetrazole;Persons;Pharmaceutical Preparations;Phenotype;Phenytoin;Potassium Channel;Predisposition;Prevalence;prevent;Proteins;Recording of previous events;Research;Rest;Risk;Rodent;Rodent Model;Safety;screening;Seizures;Sudden Death;sudden unexpected death in epilepsy;System;Testing;translational model;translational study;Type 2 Long QT syndrome;Validation;Variant

PROJECT_TITLE: Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We initiate a crucial research direction for understanding structural mechanisms of phosphatase diseases caused by mutations in PP2A. The proposed study will illuminate unprecedented super-long dynamics in PP2A regulation and disease mutations that perturb the global allosteric network near or at the super-long dynamic interface, providing general insights into the regulatory roles of disordered human proteome.

PI_NAMEs: XING, YONGNA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Active Sites;Adenine;Affect;arm;Binding;Biochemical;Brain;Cancer Patient;cancer type;Catalytic Domain;Cell Physiology;Cellular biology;Common Core;Complex;CREB1 gene;Cryoelectron Microscopy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;de novo mutation;developmental disease;Diagnosis;Disease;Dissection;early onset;Event;exome;Family;Feedback;Forskolin;genetic regulatory protein;genome sequencing;Heart Diseases;Holoenzymes;Human;human disease;inhibitor;insight;Intellectual functioning disability;Jordan;Knowledge;Link;Malignant Neoplasms;MAP Kinase Gene;member;Missense Mutation;Molecular Conformation;Molecular Diagnosis;molecular dynamics;multidisciplinary;mutant;Mutate;Mutation;Nervous System Disorder;neurodevelopment;Parkinsonian Disorders;Patients;Phase;phosphoric diester hydrolase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Play;Protein Array;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteome;Regulation;Regulatory Element;Research;Resolution;response;Role;Sampling;scaffold;Signal Transduction;simulation;single molecule;single-molecule FRET;Site;Somatic Cell;Somatic Mutation;Structure;Syndrome;Testing;Variant;whole genome

PROJECT_TITLE: Structural basis of PP2A phosphatase diseases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infectious Diseases;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative: This study is relevant to health of individuals at risk for atherosclerotic carotid plaque formation and are pre-disposed to chronic stigma/discrimination stress based upon the intersection of their HIV, gender, racial/ethnic, and sexual minoritized status. A multidisciplinary research team will compare the magnitude of response to social rejection and discrimination focusing on key neural, immune, and cardio- autonomic pathways in real-time using functional magnetic resonance imaging and ecological momentary assessment to further knowledge of underlying biobehavioral mechanisms for atherosclerotic cardiovascular disease in HIV.

PI_NAMEs: MCINTOSH, ROGER CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Adult;afferent nerve;Age;aged;Amygdaloid structure;Anterior;Anti-Inflammatory Agents;Anti-Retroviral Agents;Area;Area Under Curve;Atherosclerosis;atherosclerosis risk;Autonomic Pathways;biobehavior;blood oxygen level dependent;Brain;Brain region;calcification;cardiovascular disorder risk;cardiovascular health;Carotid Artery Plaques;Case Series;Cellular Phone;cholinergic;Chronic;cohort;Complex;coronary plaque;cytokine;design;Detection;Discrimination;Ecological momentary assessment;ethnic minority status;Ethnic Origin;experience;follow-up;Functional Magnetic Resonance Imaging;Future;Gender;Genes;Genetic Transcription;Health;Heart failure;heart rate variability;HIV;HIV Infections;Immune;immune function;indexing;Individual;Inflammation;Inflammatory;innovation;Insula of Reil;Interdisciplinary Study;Interleukin-6;intersectionality;Intervention;Knowledge;Lead;Link;Lymphocyte;Lymphoid Tissue;marginalization;Measures;Mediating;Mediation;Mediator;Methods;Modeling;monocyte;Morphology;mortality;multidisciplinary;neural;Neuroimmune;Neuroimmunomodulation;Outcome Study;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;portability;Procedures;Process;Prospective Studies;psychosocial;Race;racial minority;Recording of previous events;Regimen;Research;Resolution;response;Role;Salivary;Sex Orientation;sexual minority status;social;social relationships;social stigma;Stigmatization;Stress;System;Testing;Time;time use;ultrasound;Viral Load result

PROJECT_TITLE: Psycho-neuro-immune Mechanisms Linking Stigma and Discrimination to Carotid Plaque Formation in Persons living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-Q(02)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE We recently found two forms of cytosolic DNAs, SINE RTE DNA and mitochondrial DNA, contribute to death of the retinal cells in an aging-related disease in humans. By investigating the mechanisms by which these two cytosolic DNAs synergistically collaborate to promote aging and compromise retinal function, we will develop new knowledge that could provide new medically relevant knowledge for reducing the ill effects of aging and improving healthspan.

PI_NAMEs: AMBATI, JAYAKRISHNA  (contact);GELFAND, BRADLEY DAVID

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;age effect;Age related macular degeneration;Age related pathologies;aged;Aging;aging related disease;Alu Elements;Alzheimer's Disease;Animals;Binding;Biogenesis;Blindness;Cell Death;cell type;Cells;Cessation of life;Chromatin;Cognitive;Collaborations;Complementary DNA;Complex;Cytoplasm;cytotoxic;cytotoxicity;Data;Disease;DNA;Elements;Epidemiology;Event;Evolution;Eye;Family;Foundations;Functional disorder;Future;Generations;Genetic;geographic atrophy;Guanosine;hallmarks of aging;healthspan;Human;human disease;IL18 gene;improved;Inflammaging;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;insight;intercellular communication;Interleukin-1 beta;Joints;Knowledge;Libraries;Maps;Mediating;Medical;micronucleus;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Mus;next generation sequencing;novel;Nuclear;Pathogenesis;Pathologic;Pathology;Pathway interactions;pro-aging;Production;Property;Regulation;Retina;retinal toxicity;Retrotransposon;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;sensor;Signal Transduction;Sterility;Stimulus;Structure of retinal pigment epithelium;Testing;Therapeutic;tissue degeneration;Tissues;Toll-like receptors;Toxic effect;Vision;Visual;Voltage-Dependent Anion Channel

PROJECT_TITLE: Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: UNION

ORG_NAME: PROKARYOTICS, INC.

ORG_STATE: NJ

PHR: Narrative Widespread azole resistance among Candida and Aspergillus spp. along with emerging echinocandin resistance in C. glabrata and C. auris raises the specter of untreatable multidrug resistant fungal infections, even as advances in medicine (cancer chemotherapy, organ transplant, premature infants, HIV/AIDS therapy) have increased the size of the vulnerable population. In October 2022, the World Health Organization (WHO) published a report on the first global effort to prioritize fungal pathogens (WHO Fungal Priority Pathogens List), and Candida and Aspergillus species were placed in the most critical priority group, highlighting the need to develop mechanistically novel antifungal agents against these pathogens. This project aims to develop a novel therapeutic to treat life-threatening fungal infections due to drug resistant Candida and Aspergillus with no cross resistance to existing agents.

PI_NAMEs: ROEMER, TERRY  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;AIDS therapy;Allergic Bronchopulmonary Aspergillosis;Amphotericin B;Anabolism;analog;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Attenuated;Azole resistance;Azoles;Binding;Biogenesis;Candida;Candida albicans;Candida auris;Candida glabrata;candidate selection;Candidiasis;Cell surface;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Chemicals;Chemotherapy-Oncologic Procedure;Clinical;clinical development;clinically relevant;cytotoxicity;Data;Death Rate;Development;Disseminated candidiasis;Dose;Drug Interactions;Drug Kinetics;Drug resistance;echinocandin resistance;Enhancers;Eukaryota;Evaluation;Formulation;genome-wide;Glycosylphosphatidylinositols;Goals;Growth;health care settings;HepG2;HIV/AIDS;Human;Immune system;improved;In Vitro;in vivo;Infection;inhibitor;innovation;Ion Channel;Lead;lead optimization;Lethal Dose 50;Life;Mediating;Medicine;Metabolic;Modeling;Molds;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Multiple Fungal Drug Resistance;Mus;Mycoses;Names;Natural Products;novel;novel therapeutics;Organ Transplantation;pathogen;pathogenic fungus;Pathway interactions;Pharmaceutical Preparations;Phase;phase 3 study;Phenotype;Post-Translational Protein Processing;pre-clinical;Premature Infant;priority pathogen;Production;programs;Property;Proteins;Publishing;Reporting;Resistance;resistant Aspergillus;Resistant candida;scale up;screening;Sepsis;Series;Serum;standard of care;synergism;Systemic infection;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapeutic target;Toxic effect;Virulence;Vulnerable Populations;World Health Organization;Yeasts

PROJECT_TITLE: Development of a novel broad spectrum antifungal therapeutic targeting Glycosylphosphatidylinositol (GPI) biosynthesis and cell wall biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW ORLEANS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Subretinal fibrosis underlies the end-stage pathogenesis of several retinal diseases including age- related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). The cellular and molecular mechanism of subretinal fibrosis is still unclear, and the clinical treatment for this condition is very limited. The proposal will define the function, identity, and origin of myofibroblasts in subretinal fibrosis; and determine the therapeutic potential of miR-24 in subretinal fibrosis.

PI_NAMEs: WANG, SHUSHENG  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Age related macular degeneration;Cell Lineage;cell type;Cells;Choroidal Neovascularization;Cicatrix;Clinical Treatment;Connective Tissue;Data;Endothelial Cells;Endothelium;Epithelium;Extracellular Matrix;Fibrosis;Gene Expression Profile;Goals;Growth Factor;Hemorrhage;Human;Injury;Knock-in;Lasers;Legal Blindness;legally blind;Macrophage;MADH3 gene;Mesenchymal;MicroRNAs;Modeling;Molecular;Mus;Myofibroblast;neovascularization;overexpression;Pathogenesis;Pathway interactions;Patients;periostin;Pharmaceutical Preparations;Proliferative Vitreoretinopathy;Repression;response;Retina;Retinal Detachment;Retinal Diseases;Role;small molecule;Small Nuclear RNA;Spatial Distribution;Structure;Testing;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;Transforming Growth Factor beta;Virus;wound healing

PROJECT_TITLE: Mechanistic study and therapeutic development for subretinal fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Immunization;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed research investigates how genomic polymorphisms of TNFRSF13B predict and potentially govern the character and outcome transplantation immunity in humans. We will determine whether allelic TNFRSF13B variants of known phenotype engender donor-specific B cell responses to organ allografts and the association of those responses with transplant outcome. The functional properties of the most important TNFRSF13B alleles will be confirmed and the mechanism ascertained by engineered tnfrsf13B mutations in mice and testing such mice as recipients of heterotopic cardiac allografts.

PI_NAMEs: CASCALHO, MARILIA ISABEL (contact);PLATT, JEFFREY L

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: 5' Untranslated Regions;Acute;Address;Affinity;Alleles;Alloantigen;allotransplant;Antibodies;Antibody Formation;Antibody Response;antibody-mediated rejection;Antigens;Avidity;B-Lymphocytes;Binding;Biopsy;Cardiac;Cell Physiology;Cell Separation;Cells;Characteristics;Chronic;Clinical;Clonal Expansion;Clone Cells;cohort;Complement;Complement Activation;Complement Factor H;Development;Disabling;Discrimination;Dominant-Negative Mutation;donor-specific antibody;Engineering;Enrollment;Equilibrium;Evolution;experience;Frequencies;Gene Expression;Genes;genetic analysis;Genetic Polymorphism;Genomics;Genotype;Germ Lines;Glycocalyx;graft function;Health;heart allograft;Heart Transplantation;Homologous Gene;Human;Immune;Immune response;Immunity;Injury;Interleukin-10;Investigation;Isoantibodies;isoimmunity;Kidney Transplantation;Kinetics;Knockout Mice;Mammals;Mediating;Michigan;Mus;Mutate;Mutation;natural antibodies;nonsynonymous mutation;Organ Transplantation;Outcome;pathogen;Pathogenicity;Pathology;Phenotype;plasma cell differentiation;Population;Probability;Production;Properdin;Property;Publications;receptor;Research;Research Personnel;Resistance;response;Risk;Role;Sampling;Serum;Shapes;Specificity;Spliced Genes;Testing;Time;Tissue Grafts;trait;Transcript;transcription factor;Transplant Recipients;Transplantation;United States National Institutes of Health;Variant;Wild Type Mouse

PROJECT_TITLE: TNFRSF13B polymorphisms and immunity to transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Precision Medicine;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Mechanisms of residual cell survival following initial therapy, one of the leading causes of cancer recurrence, remain under-studied, in part due to the scarcity of tools and models to faithfully study the evolutionary dynamics of residual disease. My doctoral work will focus on designing novel imaging methodologies to visualize spatiotemporal metabolic and vascular heterogeneities during residual disease and recurrence in vivo while my postdoctoral work will focus on elucidating the molecular mechanisms that drive recurrence using faithful PDX models of triple negative breast cancer to identify actionable metabolic and vascular targets. This synergistic approach will provide a holistic understanding of the behaviors of residual tumors, guiding the development of targeted therapies aimed at eradicating residual disease to reduce or delay recurrence.

PI_NAMEs: SUNASSEE, ENAKSHI D. (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Aftercare;Anatomy;anti-cancer research;Award;Behavior;Biological Assay;Blood capillaries;Blood Vessels;Breast Cancer Model;Cancer Biology;cancer cell;Cancer Etiology;cancer recurrence;Cause of Death;Cell Survival;Cells;Characteristics;chemotherapy;Clinical;clinically relevant;Complement;Crowding;design;Development;Diameter;Disease regression;Doctor of Philosophy;Environmental Risk Factor;Exhibits;fatty acid oxidation;Fatty Acids;Functional Imaging;Gene Expression Profiling;Genetic Transcription;Genetically Engineered Mouse;glucose uptake;Glycolysis;Heterogeneity;Hypoxia;Image;imaging approach;Imaging Device;imaging Segmentation;improved;in vivo;in vivo imaging;Isotopes;journal article;Lead;Length;Link;Malignant Neoplasms;Manuscripts;Maps;mass spectrometric imaging;Membrane Potentials;Mentorship;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Microscope;mitochondrial membrane;mitochondrial metabolism;Modeling;Molecular;molecular marker;Monitor;multiple omics;MYC gene;Nature;neoplastic cell;novel;Nutrient;Oncogenes;Oncogenic;optical imaging;Outcome;Paclitaxel;patient derived xenograft model;Patients;Perfusion;Phase;Phenotype;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;preference;Preparation;pressure;Property;Recurrence;Recurrent tumor;Reporter;Research;Research Personnel;Research Project Grants;Residual Neoplasm;Residual state;Resistance;Resolution;Sampling;Seminal;serial imaging;Signal Pathway;Site;skills;spatiotemporal;Stratification;System;targeted treatment;Technology;Therapeutic;therapy outcome;therapy resistant;Tissues;tool;Training;training opportunity;translational therapeutics;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor metabolism;tumor microenvironment;Tumor-Associated Vasculature;uptake;Variant;Visualization;Work

PROJECT_TITLE: Understanding metabolic and vascular vulnerabilities of residual disease in triple negative breast cancer to inform on treatment strategies


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: Newark

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Narrative Before a newly budded HIV-1 particle becomes fusogenic (and infective) it must undergo maturation. During maturation the contents of the virion transform from a spherical shell into a conical structure after a series of cleavages of the 55 kDa Gag polyprotein by the viral protease. Here, we propose to utilize full-scale molecular dynamics simulations, integrating shaped-based coarse-grained and atomistic methods, to determine motion- structures that reveal the mechanistic details of HIV-1 virion maturation.

PI_NAMEs: PERILLA JIMENEZ, JUAN ROBERTO (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Adoption;Affect;Architecture;Binding;biophysical properties;Biophysics;Capsid;Capsid Proteins;Cells;Collaborations;Communities;Computing Methodologies;Cryoelectron Microscopy;Diffusion;Equipment;Event;Experimental Designs;fluidity;gag Gene Products;Grain;Guide RNA;HIV Budding;HIV-1;In Vitro;in vivo;innovation;instrumentation;Membrane;Membrane Lipids;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular scale;Morphology;Motion;movie;mutant;Nucleocapsid;particle;Pathway interactions;Peptide Hydrolases;Peptides;Physical condensation;Process;protein complex;Protein Engineering;Proteins;Proteolytic Processing;Research Personnel;Resolution;Resources;Retrovirology;Series;Shapes;simulation;Site;Structure;supercomputer;Testing;Thick;Thinness;Tomogram;tool;Tubular formation;Validation;Viral;Viral Physiology;Virion;virtual reality;Virus;Work

PROJECT_TITLE: Determining the molecular mechanisms of HIV-1 maturation


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: We propose to study how manganese, an environmental toxin, affects the function of the mitochondrial RNA granule and thereby causes neuronal death. Understanding this mechanism will lead to new biomarkers of exposure and sensitivity and novel strategies for neuroprotection.

PI_NAMEs: GOKHALE, AVANTI ;WERNER, ERICA MARLIS (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acute;Adult;Adverse effects;Affect;Air;Binding;Binding Proteins;Biochemical;Biological;Biological Markers;Brain;brain cell;brain tissue;Cell Death;cell injury;Cell Line;Cell model;Cells;Cerebrum;Child;Chronic;Cognition;Cognitive;crosslink;cytokine;Cytoplasm;Cytoplasmic Granules;Diagnosis;Disease;Double-Stranded RNA;Down-Regulation;Environmental Risk Factor;Exclusion;experience;Exposure to;Foundations;Functional disorder;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Goals;Homeostasis;Human;Impairment;Individual;Induced Neurons;Inductively Coupled Plasma Mass Spectrometry;Industry;Inflammatory;Inflammatory Response;interest;Intervention;Knock-out;Knockout Mice;Manganese;Manganism;Mass Spectrum Analysis;Measures;Metabolism;Metal exposure;Metals;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Mitochondrial RNA;Modeling;Molecular;Molecular Target;Movement;Movement Disorders;Mus;Mutation;Nerve Tissue;Neurologic;neuron loss;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;novel strategies;Occupational;Organoids;overexpression;Oxidative Stress;Parkinsonian Disorders;Particulate Matter;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phenocopy;pollutant;Population;Predisposition;Production;protein expression;Proteins;proteostasis;Public Health;Reactive Oxygen Species;Reporter;Research Design;Respiration;Respiratory Chain;response;Ribosomes;Risk;RNA;RNA Processing;Role;Signal Transduction;Testing;Time;tool;Toxic effect;Toxic Environmental Substances;Transcript;Water

PROJECT_TITLE: Mitochondrial mechanisms and signaling in manganese exposure

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: Project Narrative Alzheimer’s disease (AD) and AD-related dementias (ADRD) disproportionately impact Hispanic Americans, who represent the fastest-growing segment of the elderly population in the US and particularly in Texas, but this ethnic group is severely underrepresented both in research study participants and in the research workforce. To overcome these deleterious shortfalls, the University of Texas Rio Grande Valley (UTRGV) AD/ADRD-RCMAR will build upon longstanding strengths in social and behavioral science at UTRGV (located in the impoverished and 90% Mexican American-populated US/Mexico border region) and facilitated by a partnership with the South Texas AD Research Center, will continue to lead and coordinate efforts in South Texas to enhance the diversity and capacities of the workforce of minority aging research. This effort will catalyze increased research participation by Hispanic Americans and develop a robust infrastructure and data collections for high-impact research aimed at reducing the impacts of AD/ADRD on Hispanic Americans.

PI_NAMEs: MAESTRE, GLADYS E. (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Abbreviations;Academy;Address;Age of Onset;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavior;Behavior Therapy;Behavioral;Behavioral Model;Behavioral Research;Behavioral Sciences;Cardiovascular Diseases;Cardiovascular system;career development;Caring;Cognitive;cohort;Communities;community engagement;community organizations;Complex;complex data;Data Analyses;Data Collection;Databases;dementia risk;Development;Diabetes Mellitus;Diagnosis;Discipline;Discrimination;Disparate;Disparity;early life adversity;Early Onset Alzheimer Disease;Economic Burden;Education;education research;educational atmosphere;Educational Status;Elderly;Ethnic Population;evidence base;Exhibits;experience;Exposure to;Faculty;Family;Fostering;Funding;Genetic;Goals;Growth;Health;health disparity;Health Personnel;Health Promotion;Health Sciences;Healthcare;Healthcare Systems;High Prevalence;Hispanic;Hispanic Americans;Hispanic Populations;Hispanic-serving Institution;improve minority health;Incidence;Individual;Infrastructure;innovation;Institution;Intervention;Ions;Kansas;Knowledge;Lead;Leadership;Letters;Life Style;Measures;Mediating;Mentors;Mentorship;Mexican Americans;Mexico;Minority;minority health;Minority Health Research;Modeling;multidisciplinary;Neighborhood Health Center;neuroimaging;Neuropsychology;Neurosciences;Neurosciences Research;Not Hispanic or Latino;Obesity;Participant;Pathway interactions;Personal Satisfaction;Pilot Projects;Population;Positioning Attribute;Poverty;Prevention;Probability;programs;Public Health;racial population;recruit;Research;Research Infrastructure;Research Personnel;research study;Research Training;Resources;Risk Factors;Science;Scientist;skills;social;Social Change;Social Development;social interventions;Social Sciences;sociodemographics;socioeconomics;Source;South Texas;Testing;Texas;Textiles;therapy development;Time;Training;Training and Education;Training Programs;trait;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;working group

PROJECT_TITLE: Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for Progress


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Administrative Coordination;Administrative Efficiency;Advisory Committees;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Annual Reports;Behavioral;behavioral study;Budgets;career;Collaborations;Communication;Communities;community advisory board;cost effective;Diabetes Mellitus;Discipline;Doctor of Philosophy;Education;education research;Elderly;Ensure;environmental enrichment for laboratory animals;equity, diversity, and inclusion;Evaluation;experience;Fostering;Funding;Goals;Grant;health disparity;Hispanic;Hispanic Americans;Hispanic Populations;Infrastructure;innovation;Institution;Ions;Leadership;Maintenance;medically underserved;meetings;Mentors;Mexico;Minority;minority investigator;Mission;Neurosciences;Obesity;Pilot Projects;Population;Prevalence;Productivity;professor;programs;recruit;Reduce health disparities;Research;research and development;Research Personnel;research study;Resources;Scientist;skills;social;South Texas;Supervision;synergism;System;Talents;Texas;Training;underserved minority;Universities;women faculty;Work

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Hematology;Rare Diseases

PHR: PROJECT NARRATIVE  Thrombocytopenia (low platelet count) is a common condition that places patients at risk for life- threatening hemorrhage, and can be caused by low levels of the sugar molecule sialic acid on the platelet surface. The aim of this proposal is to define where and how sialic acid is removed from the surface of platelets. This work will illuminate fundamental aspects of platelet biology and will pave the way for development of effective therapies for thrombocytopenia.

PI_NAMEs: HOLLENHORST, MARIE  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acceleration;Alberta province;Antibodies;Asialoglycoproteins;Autoantibodies;Biochemical;Biochemistry;Biology;Blood Platelets;Carbohydrates;career development;Chemicals;Clinical;cold temperature;Cryopreservation;Development;Development Plans;Disease;effective therapy;Enzymes;Excision;experimental study;Flow Cytometry;General Hospitals;Glycobiology;Glycoproteins;glycoproteomics;glycosylation;Half-Life;Hematology;Hemorrhage;Human;Idiopathic Thrombocytopenic Purpura;Immune Sera;In Vitro;in vivo;Incubated;inhibitor;innovation;International;Isoenzymes;Knowledge;Laboratories;Lead;Lectin;Life;Link;liquid chromatography mass spectrometry;Massachusetts;Measures;Mediating;member;Membrane Glycoproteins;Mentorship;Molecular;mouse model;mucinase;Mucins;Mus;Neuraminidase;Non-Malignant;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Physicians;Platelet Count measurement;Platelet Membrane Glycoproteins;platelet storage;Platelet Transfusion;Polysaccharides;Positioning Attribute;Process;Proteins;Proteomics;Recombinants;Research Personnel;Resistance;Risk;Scientist;Sialic Acids;sialylation;small molecule;small molecule inhibitor;Stimulus;sugar;Surface;targeted treatment;Techniques;Testing;Thrombocytopenia;Time;tool;Training;Transfusion;transfusion medicine;Universities;Work

PROJECT_TITLE: Biochemistry of Platelet Desialylation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: BLANGERO, JOHN  (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;base;Behavior Therapy;Behavioral;behavioral and social science;Behavioral Sciences;Bioinformatics;Biological;Biological Markers;Biometry;Brain;Budgets;career;Caregivers;Caring;cluster computing;cognitive function;Collaborations;Communities;Complex;Data;Data Analyses;data resource;Data Set;Dementia;design;Development;Diabetes Mellitus;Discipline of Nursing;Disease;Doctor of Philosophy;Early Onset Alzheimer Disease;education research;Environment;Epidemiology;experience;Faculty;Family;Fostering;Funding;Genetic;Goals;Healthcare Systems;high dimensionality;High Performance Computing;high risk;Hispanic Americans;Human Genetics;improved;Infrastructure;Instruction;Integrative Therapy;interest;Intervention;Intervention Studies;Ions;large datasets;Leadership;Longitudinal cohort;Measurement;medical schools;member;Mentors;method development;Methodology;Methods;Mexican Americans;Mexico;Minority;Minority Groups;minority investigator;Modality;Molecular Biology;multidimensional data;Neurology;Neurosciences;NIH Program Announcements;non-genetic;novel;Obesity;Observational Study;Participant;Patients;Persons;pharmacologic;Pharmacotherapy;Phenotype;Pilot Projects;Population;Poverty;professor;programs;Psychiatry;recruit;repository;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Risk;risk stratification;Scientist;skills;social;social interventions;social science research;Social Work;Sociology;South Texas;Structure;System;Texas;therapy development;Thinking;tool;Training;Training Activity;Underrepresented Populations;Universities

PROJECT_TITLE: Analysis Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: 8. PROJECT NARRATIVE  Imidacloprid is a small and relatively water-soluble pesticide with high likelihood of environmental accumulation and chronic exposure of non-target species such as humans. The proposed research project will investigate the mechanisms of toxicity and detoxification of imidacloprid in immature and mature mammalian ovaries as well as characterize novel drug targets within the ovaries such as metabolic enzymes and acetylcholine receptors. The public health outcomes of this work include identification of possible reproductive toxicants and development of methods to prevent or treat pesticide-induced reproductive problems.

PI_NAMEs: MOURIKES, VASILIKI  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: absorption;Acetylcholine;Acids;Affinity;agricultural pesticide;Agriculture;antioxidant enzyme;Apoptotic;base;Binding;Biological Monitoring;Birds;Brain;carbamate insecticide;Carbamates;Cell Cycle;Cells;Chemicals;China;Choline;Cholinergic Receptors;Chronic;Coupled;Culture Media;Dangerousness;Dermal;Detection;Dose;drinking water;Drug Metabolic Detoxication;Enzyme Inhibitor Drugs;Enzymes;Excision;experimental study;exposed human population;Exposure to;Fishes;Fleas;Frequencies;Gastrointestinal tract structure;Gene Expression;Gonadal Steroid Hormones;Home;Hormone Receptor;Hormones;Hour;Human;imidacloprid;In Vitro;in vivo;Industry;Inhalation;Insecta;Insecticides;Kidney;Learning;Literature;Liver;Mammals;Marketing;Mastication;Measures;Messenger RNA;Metabolic;method development;Morphology;mRNA Expression;Mus;Neurotoxins;new therapeutic target;Nicotine;novel;Oral Ingestion;Organophosphates;Outcome;Ovarian;Ovarian Follicle;Ovary;ovotoxicity;Oxidative Stress;Oxidative Stress Induction;Parents;Pathologic;Pathway interactions;Pesticides;Pharmacologic Substance;Plasma;Play;postsynaptic neurons;Predisposition;prevent;Privatization;Proteins;Public Health;Rattus;receptor;reproductive;reproductive function;Research Project Grants;Research Technics;Research Training;Role;skills;Small Interfering RNA;small molecule;Source;Steroid biosynthesis;Structure;sucking;System;technical writing;Testing;Ticks;Time;Toxic effect;toxicant;transcriptome sequencing;United States;Water;water treatment;Work

PROJECT_TITLE: Toxicity and Detoxification of Imidacloprid in the Murine Ovary

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Women's Health Research

ORG_CITY: Apex

ORG_NAME: COUPLET CARE, LLC

PHR: Narrative - While postpartum rooming-in has become the new standard-of-care, the ongoing use of bassinets designed for use by ambulatory nursery staff has resulted in risk of infant drops/falls and maternal frustration, as the difficulty of accessing infants has led mothers to either experience significant pain or injury during infant transfer or rely on nurses/others for assistance with non-medical needs. The iatrogenic obstacles conveyed by existing bassinets can contribute to newborns being on maternity beds or held on chairs while the adult is asleep, instead of being in the secure sleeping environment of the bassinet, increasing the risk of drops or suffocation events. Addressing these issues, Couplet Care is developing a novel bassinet that is heigh-adjustable and can be positioned over the hospital bed, facilitating access to the infant and promoting safe mother-infant bonding and care during rooming-in, while also reducing demands on nurses who may already be short-staffed.

PI_NAMEs: MCENTYRE, STACIE  (contact);TOMORI, CECILIA ;TULLY, KRISTIN PATRICIA

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Adopted;Adult;arm;Asphyxia;Beds;Birth;Breast Feeding;Caring;Certification;Cesarean section;Client satisfaction;Clinical;Contracts;Coping Skills;Coupled;Data;design;Development;Devices;Documentation;Drops;Electronic Health Record;emotional trauma;Ensure;Environment;Event;experience;Exposure to;falls;Fatigue;Feedback;Frustration;healing;Health Personnel;Height;Hospital Administrators;hospital bed;hospital care;Hospitalization;Hospitals;Hour;Iatrogenesis;improved;Infant;Infant Care;Injury;innovation;Instruction;International;Interview;Learning;Length of Stay;manufacture;Manufacturer;manufacturing process;Medical;Medical Care Team;Medical center;Medical Device;member;Methods;Midwife;Mobility decline;Modeling;mortality;Mothers;Newborn Infant;next generation;novel;Nurses;operation;Outcome;Pain;Parents;Participant;Patient-Focused Outcomes;Patients;Persons;Phase;Positioning Attribute;postnatal;Postpartum Period;prescription opioid;Procedures;Process;Protocols documentation;prototype;Questionnaires;Recommendation;Recovery;Regulation;Reporting;Risk;Risk Reduction;Safety;Secure;Site;Skin;Sleep;sleep pattern;standard of care;Surveys;System;Term Birth;Testing;UNICEF;Update;usability;Vagina;Weight;Woman;Work;World Health Organization

PROJECT_TITLE: Development of the Couplet Care Bassinet to support safe implementation of skin-to-skin contact and rooming-in on postnatal units


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MAHANEY, MICHAEL CHARLES (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Award;Behavior Therapy;Behavioral;Belief;Budgets;career;career development;Career Mobility;Caring;Classification;cohort;Communities;community engaged research;Country;Data Analyses;Dementia;design;Development;Development Plans;Diabetes Mellitus;disability;Doctor of Philosophy;education research;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Extramural Activities;Faculty;Funding;geographic population;Goals;Grant;Health;Health Disparities Research;health disparity;high risk;Hispanic;Hispanic Americans;hispanic community;Hispanic Populations;improved;Information Dissemination;Infrastructure;innovation;Interdisciplinary Study;investigator training;Ions;Knowledge;Leadership;Logistics;medically underserved;Medically Underserved Area;member;Mentors;Mexican Americans;Mexico;Minority;Minority Groups;Neurosciences;Not Hispanic or Latino;Obesity;Persons;Pilot Projects;Population;Positioning Attribute;Poverty;Preparation;Prevalence;Problem behavior;programs;Publications;Race;recruit;Reduce health disparities;Research;Research Personnel;Research Project Summaries;Research Support;Resources;responsible research conduct;Science;Scientist;senior faculty;Series;Services;social;Social Problems;South Texas;Statistical Data Interpretation;Surveys;symposium;Texas;therapy development;Training;translational impact;Underrepresented Minority;underserved community;Universities;Work;Writing;years of life lost

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MANUSOV, ERON GRANT (contact)

PROJECT_TERMS: Adoption;Advocate;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Behavioral;Behavioral Research;Belief;Biomedical Research;Capital;Caring;Cavia;Clinical Research;Clinical Trials;Collaborations;Color;Communication;Communities;community academic partnership;community based research;Community Developments;community engagement;Community Health;community organizations;community research;Competence;Consultations;cost;diversity and inclusion;Doctor of Medicine;Education;education research;Elderly;empowerment;Exclusion;experience;Family;Family Practice;Feedback;Goals;Health;Health Personnel;Hispanic;Hispanic Americans;Hispanic Populations;Hispanic-serving Institution;Human Genetics;Incentives;Individual;Infrastructure;Instruction;interest;Kansas;Knowledge;Language;Leadership;Learning;Link;Locales;Maintenance;medical schools;member;Mentors;Mentorship;Metaphor;Mexican Americans;Mexico;Minority;minority health disparity;minority investigator;older adult;Older Population;Participant;Pilot Projects;Policy Maker;Politics;Population;Positioning Attribute;prevent;professor;recruit;Reduce health disparities;Reporting;Research;Research Personnel;research study;Resources;Rural;Scientist;social;social capital;Social Environment;societal costs;South Texas;success;Surveys;System;Taste Perception;Texas;theories;Time;Training;Translational Research;Uncertainty;Universities;Work;working group;World Health Organization

PROJECT_TITLE: Community Liaison and Recruitment Core


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Autism spectrum disorders have complex etiologies, involving both genetic and in utero environmental factors. A novel gene locus was identified from placental samples collected prior to the diagnosis of autism, called NHIP (neuronal hypoxia inducible, placenta associated). To understand why NHIP levels were lower in autism brain and placenta, this study will identify the molecular functions and regulators of NHIP and test its efficacy in protecting embryonic neurons from oxidative stress.

PI_NAMEs: LASALLE, JANINE M (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 22q13;Adult;Affinity;Amino Acids;Animal Model;Antioxidants;Autism Diagnosis;autism spectrum disorder;Autopsy;Back;Binding;Binding Proteins;Biological Assay;Birth;Brain;Cell Hypoxia;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chromatin;chromatin immunoprecipitation;cohort;comparison control;Complex;Consumption;CRISPR/Cas technology;Data;Disease;disorder risk;Distal;DNA Methylation;DNA-Binding Proteins;Early Intervention;Embryo;Encapsulated;Energy consumption;Engineering;Enhancers;Environmental Risk Factor;Epigenetic Process;epigenome;epigenome-wide association studies;Etiology;fetal;Folic Acid Deficiency;Future;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;genomic locus;Genomics;Genotype;Goals;high risk;Human;human fetal brain;human model;Hypoxia;in utero;In Vitro;in vivo;in vivo Model;inhibitor;lipid nanoparticle;Maps;maternal obesity;Messenger RNA;Metabolism;Methyl-CpG-Binding Protein 2;Methylation;Mitochondria;model of autism spectrum disorder;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;Names;nanoparticle delivery;nerve stem cell;neurogenesis;Neuronal Differentiation;Neuronal Hypoxia;Neurons;neuroprotection;novel;overexpression;Oxidative Stress;Oxidative Stress Induction;Oxidative Stress Pathway;Oxygen;Oxygen Consumption;Pathway interactions;Peptides;Phenotype;Placenta;Placenta Diseases;polygenic risk score;Pre-Clinical Model;Pregnancy;Primates;promoter;Property;prospective;protein complex;protein protein interaction;Proteins;Proteomics;Publishing;Regulation;Reporter;Research;resilience;Respiration;response;Response Elements;Rett Syndrome;risk variant;RNA Processing;RNA Splicing;Sampling;small molecule therapeutics;Structure;Synapses;Testing;Therapeutic;Therapeutic Intervention;traffic-related air pollution;Transactivation;Transcript;Transcription Coactivator;transcription factor;Transcriptional Activation Domain;Translating;Translations;Valproic Acid

PROJECT_TITLE: Placental identified NHIP regulating neuronal oxidative stress in autism

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

PHR: Project Narrative: As metabolism is at the core of physiology, metabolomics and proteomics are the ideal platforms to characterize an integrated view of failures in arginine metabolism in people who develop delirium following elective surgery. Of these patients, ~17% are at greater risk of developing Alzheimer’s disease or one of its related dementias (ADRD), equating to ~170k people in the US in 2018. Such information could provide totally novel insights about disease mechanisms and progression, providing a biochemical roadmap for novel treatment development. Further, we aim to develop and fully validate a CSF based test to predict those people at greatest risk of developing delirium and subsequently ADRD. In this application, we enrich our efforts by bringing together world experts in metabolomics, delirium, and molecular modelling to build an atlas for aberrant arginine metabolism in delirium sufferers while developing predictive tests for those at greatest risk.

PI_NAMEs: CUNNINGHAM, EMMA LOUISE;GRAHAM, STEWART F (contact);GREEN, BRIAN

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Anesthesia procedures;Arginine;Atlases;Biochemical;Biological Markers;biomarker panel;Brain;brain health;Caring;Clinical;Clinical assessments;Clinical Data;Cognitive;cognitive testing;cohort;Collaborations;Complement;Conduction Anesthesia;Counseling;Data;Data Set;Delirium;Dementia;Development;Disease;Elderly;Ensure;Enzymes;Equation;Event;experience;Failure;follow-up;Functional disorder;Funding;Future;Gender;Genetic;Goals;Health;Hip region structure;hip replacement arthroplasty;Impaired cognition;Impairment;Incidence;Individual;insight;Intervention;Knee;knee replacement arthroplasty;Longterm Follow-up;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;molecular modeling;Molecular Target;Nerve Degeneration;neural;novel;novel marker;older adult;Older Population;operation;Operative Surgical Procedures;Outcome;Pathway interactions;patient population;Patient Recruitments;Patients;Perioperative;Persons;Pharmaceutical Preparations;Physiology;Pilot Projects;Population;population based;postoperative delirium;Postoperative Period;prediction algorithm;predictive test;Prevalence;Procedures;Process;prospective;Prospective Studies;protein expression;Proteomics;Randomized, Controlled Trials;recruit;Replacement Arthroplasty;repository;Resolution;Risk;Risk Factors;risk prediction;Role;Sampling;screening;Spinal Anesthesia;tau-1;Testing;therapy development;tool;Total Hip Replacement;Validation;Work

PROJECT_TITLE: Are the impairments of arginine metabolism as found in Alzheimer's disease also present in patients developing post-operative delirium and cognitive decline?

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Public Health Relevance Statement This project will investigate the mechanism of collagen fibril degradation by matrix metalloproteases (MMPs). Collagen degradation plays an essential role in tissue remodeling and cell invasion and underlies many diseases, including numerous skin diseases, cancer metastasis, wound, inflammation, pneumonia, and atherosclerosis. Understanding the mechanism of degradation can significantly impact public health by identifying better therapeutic targets and strategies.

PI_NAMEs: SARKAR, SUSANTA KUMAR (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Active Sites;Affect;Allosteric Site;Animals;Atherosclerosis;Binding;Biochemical;Biological Assay;Buffers;Catalysis;Catalytic Domain;Cause of Death;Cells;Collagen;Collagen Fibril;Collagen Type I;Communication;Complement;Disease;Distant;Drug usage;Dyes;experimental study;Extracellular Matrix;Family;Fibrillar Collagen;fluorescence microscope;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;gel electrophoresis;Gelatinase A;Goals;Health;Hemopexin;Home;Human;Human body;Image;Immobilization;improved;in vitro Assay;Individual;Inflammation;inhibitor;innovation;Invaded;Kinetics;Label;Lead;Learning;Ligand Binding;Ligands;Location;Maps;Measures;member;Metalloproteases;Methods;MMP9 gene;Molecular Conformation;molecular dynamics;monomer;Morphology;Motion;mutant;Mutation;Neoplasm Metastasis;Organ;Pathologic;Pathologic Processes;Physiological;Play;Pneumonia;Proteins;Proteolysis;Public Health;public health relevance;reconstitution;Relaxation;Resistance;Resolution;Role;scaffold;Scanning Electron Microscopy;screening;self assembly;side effect;simulation;single molecule;Site;skin disorder;small molecule;Specificity;Structure;Surface;Temperature;Testing;Tetracyclines;Therapeutic;therapeutic target;Time;Tissues;triple helix;Variant;Water;Weight;wound

PROJECT_TITLE: Allosteric control of collagen fibril degradation by matrix metalloprotease-1

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Conceptual significance: Results of this research are expected to have high impact on our understanding of mechanisms of  processing and coding of salient stimuli along sensory pathways. The proposed research project aims to test fundamental qualitative  changes in coding frameworks of auditory and visual pathways and investigate underlying processing and information flow mediating  these changes, a novel and promising research that could explain how salience of sensory inputs is processed and encoded in the  brain, which is fundamental to how we perceive and interact with the world around us.  Technical significance: The proposed action uses innovative multielectrode recording techniques in awake and behaving animals to  understand flow of information and coding of salient stimuli from midbrain to forebrain audiovisual regions. In addition, it will implement  and interdisciplinary approach, combining recording of neuronal population responses and computational modeling of coding and  processing schemes.

PI_NAMEs: FISCHER, BRIAN J;PENA, JOSE L (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Adaptive Behaviors;Anesthesia procedures;Animals;Attention;Auditory;auditory pathway;auditory stimulus;awake;Barn Owls;base;Behavior;Behavioral;behavioral response;Brain;Brain region;career;Cell Nucleus;Code;Collaborations;comparative;Computer Models;concept mapping;Conduction Anesthesia;Decision Making;diversity and inclusion;Electrodes;Ethnic Population;gaze;Gender;Goals;Inferior Colliculus;innovation;interdisciplinary approach;International;Knowledge;Location;Maps;Mediating;member;Methods;Midbrain structure;Modality;Modeling;multisensory;neural;Neurons;neurophysiology;novel;Pathway interactions;Perception;Physiological;Population;Postdoctoral Fellow;Process;Property;Prosencephalon;Protocols documentation;Publications;Reporting;Research;Research Project Grants;Research Proposals;Resolution;response;Scheme;Science;selective attention;Sensory;sensory input;sensory stimulus;Signal Transduction;Sound Localization;Source;Stimulus;Strigiformes;Structure;superior colliculus Corpora quadrigemina;Techniques;Tectum Mesencephali;Testing;Thalamic structure;training opportunity;Translating;undergraduate student;Visual;Visual Pathways;visual stimulus

PROJECT_TITLE: CRCNS:US-lsrael Research Proposal: To Elucidate Fundamental Mechanisms of Transformed Saliency Map to

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Medulloblastoma (MB) is the most common malignant childhood brain tumor, and the prognosis remains poor. Here, we will develop drug delivery strategies to target MB that has metastasized to the spinal cord. We expect to identify new opportunities to improve MB therapy.

PI_NAMEs: SIRIANNI, RACHAEL W (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: actinomycin;Address;Affect;aggressive therapy;Angiopoietin-2;Antibiotics;Attention;Bar Codes;biocompatible polymer;biodegradable polymer;Blood;Brain;Brain Neoplasms;brain parenchyma;burden of illness;cancer cell;Cell Culture Techniques;Cells;Central Nervous System Neoplasms;Cerebellum;Cerebrospinal Fluid;chemotherapy;Childhood Malignant Brain Tumor;cisterna magna;Clinical;clinical translation;Data;design;Diagnosis;Disease;drug action;Drug Delivery Systems;Drug Design;drug discovery;drug efficacy;Drug Targeting;effective therapy;efficacy testing;Encapsulated;Ensure;ethylene glycol;Excision;Exhibits;expectation;Formulation;Genetic Engineering;Growth;high throughput screening;high-throughput drug screening;Human Characteristics;human disease;improved;In Vitro;in vivo;Individual;Infiltration;Injections;innovation;interest;Intravenous;intravenous administration;Ligands;Low Dose Radiation;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Meninges;Metastatic Neoplasm to the Leptomeninges;Metastatic Neoplasm to the Spine;Methods;Modeling;Modification;Molecular;Movement;Mus;nanoparticle;nanoparticle delivery;nanopolymer;Neoplasm Metastasis;Nervous System;Nervous System Disorder;novel strategies;Operative Surgical Procedures;Outcome Study;Patients;Pediatric Neoplasm;Peptides;Pharmaceutical Preparations;poly(lactic acid);polypeptide;Primary Neoplasm;Prognosis;Radiation;Radiation Dose Unit;Radiation induced damage;receptor;Resolution;Route;side effect;Site;small molecule;Spinal Cord;Subarachnoid Space;Surface;Survivors;System;targeted delivery;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapy outcome;Time;Tissues;tool;Toxic effect;Treatment Efficacy;treatment response;Treatment Side Effects;tumor;tumor growth;Work

PROJECT_TITLE: Targeting Leptomeningeal Metastasis in Medulloblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Bioengineering;Rare Diseases

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative This proposal involves developing techniques for measuring the energetics of G-protein coupled receptors in an atomic force microscopy assay without chemical denaturant. The techniques will be applied to arginine vasopressin receptor 2, informing the molecular origins of nephrogenic diabetes insipidus. More generally, development of these techniques will establish a paradigm in which energetic measurements may be made directly on biomedically relevant systems, rather than model systems.

PI_NAMEs: JACOBSON, DAVID R (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: absorption;alpha helix;argipressin receptor;Atomic Force Microscopy;Bacteriorhodopsins;Binding;Biochemical;Biological Assay;Biological Models;Cell surface;Chemicals;collecting tubule structure;Colorado;comparative;Detergents;Diabetes Insipidus;Disease;disease-causing mutation;Environment;experimental study;Free Energy;G-Protein-Coupled Receptors;Geometry;Goals;Human;insight;Isomerism;Learning;Ligand Binding;Ligands;Light;Link;Lipid Bilayers;Lipids;Measurement;Measures;membrane model;Membrane Proteins;Mentors;Methods;Micelles;Molecular;Molecular Chaperones;Molecular Conformation;Movement;mutant;Mutation;N-terminal;non-Native;Nucleic Acids;Pharmaceutical Preparations;pharmacologic;Phase;Photons;Point Mutation;Postdoctoral Fellow;Proline;Protein Biochemistry;Protein Dynamics;protein folding;Proteins;Residual state;response;Retina;Sampling;Scanning Probe Microscopes;single molecule;Site;Structure;System;technique development;Techniques;Testing;Thermodynamics;Time;Training;Universities;Urine;Use of New Techniques;Vasopressin Antagonist;Vasopressin Receptor;vasopressin resistant diabetes insipidus;Vasopressins;Work;X ray diffraction analysis

PROJECT_TITLE: Single-molecule Measurements of Membrane-protein Folding and Ligand-Interaction Energetics in Bacteriorhodopsin and the Diabetes-insipidus-involved Vasopressin Receptor 2

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Bipolar Disorder;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: Paramus

ORG_NAME: PSYCHOGENICS, INC.

PHR: PROJECT NARRATIVE There is a great unmet need to improve success rate in drug discovery for psychiatric disorders due to the high rate of failure. Given the need to address poly pharmacology and create truly novel chemistry for complex CNS disorders, PsychoGenics Inc. and Collaborations Pharma Inc. are joining forces to develop a novel machine learning-based drug discovery platform that can design novel compounds and predict their phenotypic therapeutic potential to guide the early stages of target-agnostic unbiased CNS drug development.

PI_NAMEs: BRUNNER, DANIELA  (contact);EKINS, SEAN

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: Address;algorithm training;Algorithms;analog;Animal Model;Antipsychotic Agents;Anxiety;autism spectrum disorder;Behavioral;Biological;Biological Assay;Biological Models;Bipolar Disorder;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Chemicals;Chemistry;Clinical Trials;Cognition;Collaborations;Collection;Complex;Data;Data Set;Decision Trees;deep neural network;Descriptor;design;Development;Diffusion;Dose;Drug Design;drug development;drug discovery;Drug Screening;drug-like compound;effective therapy;Ensure;Expert Systems;Failure;Fee-for-Service Plans;Fingerprint;Generations;generative models;improved;In Vitro;in vivo;in vivo evaluation;innovation;Lead;Libraries;Ligands;Logistic Regressions;Machine Learning;machine learning method;machine learning model;Mental Depression;Mental disorders;Methods;Modeling;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;novel;novel therapeutics;Outcome;Output;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;phase III trial;Phenotype;pre-clinical;prediction algorithm;Property;Psychoses;random forest;response;Schizophrenia;screening;Series;side effect;Small Business Innovation Research Grant;small molecule;small molecule libraries;statistics;stereochemistry;Structure;success;support vector machine;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Toxic effect;Training;Validation;Work

PROJECT_TITLE: Machine Learning Phenotypic De Novo Drug Design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: The multifarious needs of ADRD caregivers often remain unaddressed, and the utilization rate of supportive services remains strikingly low, with many caregivers uncertain about what services may be right for them, what exists, and how to access them. There is a need for a robust, reliable tool that comprehensively evaluates ADRD caregiver needs with a mechanism to connect needs with existing services, thereby overcoming barriers that ADRD caregivers face in accessing needed supportive care. The proposed project seeks to iteratively develop and test an online self-assessment and tailored referral platform, grounded in machine learning principles and informed by stakeholder perspectives, to address needs and enhance knowledge and use of relevant services, with the overall goal of linking ADRD caregivers with relevant support and thereby promoting their mental health and well-being.

PI_NAMEs: FALZARANO, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;adverse outcome;Aging;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;Anxiety;anxiety symptoms;Area;Assessment tool;Attention;attentional control;Award;Awareness;behavior test;Behavior Therapy;care recipients;career development;Caregiver support;Caregivers;caregiving;Caring;Categories;Clinical;community collaboration;community partners;Complement;Complex;Data;Dementia;dementia care;Dementia caregivers;dementia caregiving;demographics;depressive symptoms;design;Development;Diagnosis;digital;Effectiveness;efficacy study;Employment;evidence base;experience;Face;Failure;falls;Family;Family Caregiver;family support;Feedback;Fostering;Fright;Funding;Geography;Goals;Grant;Grief reaction;Guilt;Health;Health Promotion;Healthcare Systems;improved;inattention;Individual;innovation;Institutionalization;Internet;Intervention;Interview;Knowledge;Leadership;Learning;Legal;Link;Literature;Loneliness;Machine Learning;machine learning algorithm;machine learning model;Measurement;Measures;Mental Depression;Mental Health;Modeling;Needs Assessment;Outcome;Output;Participant;Patients;Personal Satisfaction;Persons;Phase;pilot test;Play;preference;primary outcome;programs;Psychologist;Psychometrics;Publishing;Quality of Care;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;reduce symptoms;referral services;Reporting;Research;research and development;Research Personnel;Resources;respite care;Respondent;Role;satisfaction;Scientist;secondary outcome;Self Assessment;Self Efficacy;Services;Severities;Shame;skills;social stigma;software development;stakeholder perspectives;Statistical Methods;Stress;stress symptom;stressor;Structure;Support Groups;Support System;support tools;Supportive care;System;Technology;technology intervention;Testing;Time;tool;Training;United States;United States National Institutes of Health;Update;usability;user-friendly;Validation;Vertebral column;web services;web site;web-based assessment;willingness;Work;Writing

PROJECT_TITLE: The Caregiver Resource Room: Enhancing Support for Caregivers of Alzheimer's Disease and Related Dementias (ADRD)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Millions of patients undergo procedures requiring general anesthetics – drugs whose effects on the brain remain poorly understood despite continuous use for over a century. This innovative proposal combines whole brain imaging at cellular resolution with cutting edge techniques for monitoring and modulating brain activity to ultimately identify the neurons and circuits responsible for the establishment of anesthetic-induced unconsciousness. Such detailed understanding of the unconscious state is a necessary pre-requisite for improving upon existing anesthetics and will reveal the fundamental mechanisms that control the level of consciousness in health and disease.

PI_NAMEs: KELZ, MAX ;PROEKT, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Affinity;analysis pipeline;Anatomy;Anesthesia procedures;Anesthesiology;Anesthetics;Area;Arousal;Behavior assessment;Behavioral;Bioinformatics;Biological;Biological Process;Brain;Brain imaging;Brain region;Caring;Cell Nucleus;cell type;Cells;clinically significant;connectome;Conscious;Cre driver;density;designer receptors exclusively activated by designer drugs;Development;Disease;Drug Design;Drug Interactions;druggable target;Elements;experience;Fiber;FOS gene;Future;General Anesthesia;General anesthetic drugs;Genetic;Goals;Health;Hypnosis;hypnotic;Hypothalamic structure;Immunohistochemistry;immunoreactivity;improved;in vivo;Individual;innovation;interest;Intervention;Knowledge;Label;Life;Maps;Molecular;Molecular Target;Monitor;Mus;Nervous System;neural circuit;neuronal circuitry;Neurons;neurophysiology;novel;Operative Surgical Procedures;Optics;optogenetics;Partner in relationship;Patients;Pattern;pharmacologic;Photometry;Physiological;Play;Population;Prefrontal Cortex;Procedures;Property;rational design;Reporter;Research;Resolution;Role;Site;Source;Techniques;Thalamic structure;Time;Tissues;Transfection;Transgenic Mice;Transgenic Organisms;two photon microscopy;Unconscious State;Viral;Virus;Work

PROJECT_TITLE: Brain Wide Anesthetic-Active Neuronal Network

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Data Science

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE The development of omics technologies and the use of the most advanced data sciences has transformed every biomedical field and provides a limitless potential to understand biological processes and develop new treatments for human diseases. However, designing, executing, and analyzing data generated by these technologies requires significant expertise, notably missing in junior investigators. The education program described in this proposal is designed to train a new generation of diverse biomedical investigators and provide them with skills, knowledge, mentoring, professional skills, and networking to foster their pathways to independence using omics and data sciences.

PI_NAMEs: IONITA, IULIANA ;RE, DIANE BERENGERE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Age;Applications Grants;Appointment;Biological Process;Biomedical Research;broadening participation research;career;career development;career networking;Clinical Medicine;cohort;Collaborations;Communication;Data;Data Science;design;Development;Discipline;Doctor of Philosophy;Drops;early-career faculty;Education;Educational Curriculum;Educational Materials;Educational process of instructing;empowerment;Equity;Evaluation;experience;Face;Faculty;Fostering;Funding;Future;Generations;Genomics;Goals;Grant;Grant Review;Health;health equity;human disease;Hybrids;improved;Institution;instructor;interest;Investments;Knowledge;Leadership;learning strategy;marginalized population;member;Mentors;Methods;microbiome;multidimensional data;multidisciplinary;National Institute of General Medical Sciences;outreach;Pathway interactions;Persons;Positioning Attribute;Postdoctoral Fellow;Precision Medicine Initiative;professor;Program Description;programs;Qualitative Evaluations;Quantitative Evaluations;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Risk;Route;Science;Scientist;Secure;skill acquisition;skills;Social Sciences;Structure;success;symposium;Technology;tenure track;Time;tool;Training;training data;Training Programs;Travel;trend;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;virtual;Woman;Writing

PROJECT_TITLE: The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigators


NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Dental, Oral, and Craniofacial Disease;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Community water fluoridation may affect perinatal health outcomes, but this has never been evaluated in the United States. It is critical to understand how this widespread practice affects the health of mothers and infants, and whether subgroups of the population are uniquely vulnerable. This project will provide critical information to assist public health officials in making informed decisions about the ongoing practice of adding fluoride to water supplies in the United States.

PI_NAMEs: GOIN, DANA E (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: adverse birth outcomes;adverse pregnancy outcome;Affect;Amniotic Fluid;Area;Arsenic;Award;Biological Process;Birth;Birth Records;Birth Weight;California;Cardiovascular system;Characteristics;Child;Child Health;clinical decision-making;cohort;Communities;Community of Practice;Consumption;Country;Data;Data Science;Development;Disparity;drinking water;Education;Endocrine Disruptors;Endocrine system;environmental chemical;Environmental Exposure;Environmental Hazards;Environmental Risk Factor;Epidemiologist;Exposure to;fetal;Fetal Growth;Fetus;Fluorides;Funding;Future;Gestational Age;Goals;Grant;Health;health of the mother;healthy pregnancy;High Risk Woman;Hormones;Hypertension;Illinois;improved;in utero;Individual;Infant;Infant Health;Knowledge;Lead;lead exposure;Life;Link;Low Birth Weight Infant;low socioeconomic status;Machine Learning;male;Maternal Exposure;Maternal Health;Measures;Mentorship;Metal exposure;Mothers;National Institute of Environmental Health Sciences;neurodevelopment;novel;Oral health;Outcome;Oxidative Stress;Perinatal Epidemiology;perinatal health;Play;Policies;Policy Maker;Population;population health;Population Heterogeneity;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal exposure;pressure;Process;programs;Public Health;Public Health Practice;Research;Research Personnel;Risk;Role;San Francisco;Second Pregnancy Trimester;Services;sex;Shapes;Small for Gestational Age Infant;social;social factors;Socioeconomic Status;Statistical Methods;Subgroup;System;systemic inflammatory response;Techniques;Temperature;Thyroid Function Tests;Thyroid Hormones;Time;Toxic effect;toxic metal;Training;Translating;Umbilical Cord Blood;United States;United States National Institutes of Health;Universities;urinary;Urine;Variant;Vulnerable Populations;Water;Water fluoridation;Water Supply;Whole Blood;Woman;Women Status

PROJECT_TITLE: Evaluating the effect of water fluoridation on adverse birth outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The Nr4A sub-family of transcription factors are critical for consolidation of long-term memory and have been linked to diseases associated with deficits in this process, such as Alzheimer's disease. In the current project, the mechanisms underlying the regulation of memory by Nr4A transcription factors will be investigated using single cell transcriptional signatures, behavioral and proteomic approaches to uncover the gene expression patterns that regulate native protein folding, an essential process for memory formation. Findings from these studies are expected to form the basis for future work that identifies therapeutic targets to treat memory impairments associated with aging and neurodegenerative diseases.

PI_NAMEs: CHATTERJEE, SNEHAJYOTI  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Attention;Autopsy;Award;Behavioral;behavioral pharmacology;career;cell type;Cells;Chromatin;Cognitive deficits;cognitive function;collaborative environment;Computer Analysis;Data;Dementia;design;differential expression;Disease;Dominant-Negative Mutation;Dorsal;economic cost;enhancing factor;Ensure;Exhibits;experimental analysis;Family;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Profile;gene induction;Gene Targeting;Genes;genetic manipulation;Genetic Transcription;Genomic Segment;Goals;Grant;GRP78 gene;Hippocampus;Home;Human;hyperphosphorylated tau;Impaired cognition;Individual;insight;Institution;Interview;Iowa;Label;Laboratories;Learning;Link;Location;Long term disability;long term memory;Memory;memory consolidation;Memory impairment;Memory Loss;memory process;Mentors;Molecular;Molecular Biology;Molecular Chaperones;mouse model;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;NR4A1 gene;NR4A2 gene;old mice;overexpression;Pathogenesis;Pathologic;Pathway interactions;Pattern;Peer Review;Persons;pharmacologic;Phase;Population;Preparation;Process;Protein Biosynthesis;protein folding;protein function;Proteins;Proteomics;Psychiatry;Regulation;Research;Research Personnel;Resolution;RNA;Role;Running;Sampling;single cell analysis;single-cell RNA sequencing;skills;socioeconomics;spatial memory;tau aggregation;tau Proteins;Tauopathies;Technology;Testing;Therapeutic;therapeutic target;Time;tool;trafficking;Training;Transcript;transcription factor;Transcriptional Regulation;transcriptomics;Transgenes;Transgenic Mice;Translating;Universities;Viral;Work;World Health Organization;Writing

PROJECT_TITLE: Understanding the molecular mechanism of memory from single-cell gene expression to protein folding