ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Metabolic syndrome, arguably a pre-diabetic state, is reaching epidemic proportions worldwide and represents one of the most important public health problems today. Research training to study promising botanical agents that might impact metabolic syndrome in humans has the potential to improve health.

PI_NAMEs: BRANTLEY, PHILLIP J (contact);STEPHENS, JACQUELINE M

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Botanicals;combat;Metabolic syndrome

PROJECT_TITLE: Botanical Approaches to Combat Metabolic Syndrome


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Rural Health;Telehealth

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Diabetes Self-Management Education and Support (DSMES) is an evidence-based, small group educational program that helps people with diabetes better control blood sugar (improved hemoglobin A1c) and reduce diabetes-related complications and healthcare costs. DSMES is strikingly underutilized with fewer than 10% of eligible patients receiving this helpful service due to patient-, clinician-, and health system-level barriers that include low clinician awareness and lack of integrated referral processes between clinics and community- based DSMES programs. Our project tests a clinic level-intervention that implements an electronic clinic- community referral system and creates a practice facilitation collaborative to empower clinical teams to identify and address DSMES barriers with the goal of increasing DSMES utilization.

PI_NAMEs: LACY, MARY E. (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Adult;American;Appalachian Region;Awareness;Blood Glucose;care costs;Caring;Charge;Clinic;Clinical;combat;Communities;community clinic;Complications of Diabetes Mellitus;cost;cost effective;County;Data;Diabetes Mellitus;diabetes self-management;Diagnosis;Disease;dissemination trial;Education;Educational process of instructing;effectiveness testing;Electronics;Eligibility Determination;empowerment;Evaluation;evidence base;Face;Feasibility Studies;Geography;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Health;Health Care Costs;health disparity populations;health information technology;Health system;Healthcare Systems;implementation evaluation;implementation framework;implementation process;implementation science;implementation trial;implementation/effectiveness;improved;Individual;Information Technology;innovation;insight;Intervention;Interview;Kentucky;Maps;Morbidity - disease rate;mortality;Motivation;Outcome;Participant;Patients;Persons;Pilot Projects;Population;Practical Robust Implementation and Sustainability Model;Prevalence;primary care clinic;primary care clinician;Process;program costs;programs;Provider;Public Health;Public Health Administration;Quality of life;Randomized;Recommendation;Research Design;response;Rural;rural area;Secure;Services;skills;Surveys;System;system-level barriers;telehealth;Testing;uptake

PROJECT_TITLE: Using Practice Facilitation and Operationalizing Referral Information Technology (UP FOR IT) to Increase DSMES Utilization


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Optimal cancer and functional outcomes from surgical treatment of head and neck cancer requires the surgeon to have the ability to intraoperatively distinguish neoplastic disease from adjacent normal tissue. Our novel optical imaging FLIm technique, coupled to the da Vinci surgical system, captures and analyzes tissue autofluorescence to identify distinct tissue types and display this information onto the surgeon’s field of view during trans-oral- robotic surgery (TORS). This enables a more accurate and optimal cancer removal while preserving adjacent normal tissue and function. The successful validation of FLIm, with the sophisticated incorporation of head and neck cancer patient and radiology data to improve the tissue classifier, will allow for more cures with less long- term side effects and will be easily extended to other robotic and endoscopic procedures, thus advancing innovation well beyond TORS.

PI_NAMEs: BIRKELAND, ANDREW CHARLES;MARCU, LAURA  (contact);SORGER, JONATHAN M.

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Age;Area;Authorization documentation;Biochemical;Biological;cancer surgery;Cauterize;Characteristics;Classification;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Colorectal Cancer;Computer software;Coupled;Data;data acquisition;Data Display;data visualization;Databases;Decision Making;deep learning;design;Detection;Devices;Diagnostic;diagnostic value;Disease;Documentation;Environment;Epithelium;Excision;Feedback;flexibility;Fluorescence;fluorescence lifetime imaging;functional outcomes;Funding;Goals;Head and Neck Cancer;head and neck cancer patient;Hemostatic function;Histopathology;Human;human subject;Image;image reconstruction;image registration;Image-Guided Surgery;imaging detection;Imaging Device;Imaging Techniques;Imaging technology;improved;In Situ;information display;innovation;Intuition;Knowledge;Label;learning progression;Legal patent;Location;Malignant Female Reproductive System Neoplasm;malignant mouth neoplasm;Malignant neoplasm of thorax;Malignant Neoplasms;malignant oropharynx neoplasm;Medical Records;Metabolic;Methods;Morphologic artifacts;Motion;neoplastic;Noise;Normal tissue morphology;novel;Operative Surgical Procedures;optical imaging;Oral;Oral cavity;Oropharyngeal;Patients;Peer Review;Performance;Positron-Emission Tomography;pragmatic implementation;Predictive Value;preservation;Procedures;Property;prospective;Prospective Studies;Radiology Specialty;radiomics;Reporting;Risk Management;Robot;robotic system;Robotics;Scanning;sex;side effect;Signal Transduction;solid state;Specimen;Spectrum Analysis;Speed;Surface;Surgeon;surgery outcome;Surgical margins;Surgical Oncology;symposium;System;Testing;Time;Tissues;tumor;Urologic Cancer;Validation;Visual;Visualization

PROJECT_TITLE: Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery Guidance


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Public Health Relevance Statement This study serves as a basis for understanding the intrinsic and extrinsic defects in skeletal muscle repair and will shed light on both predicting outcomes of rotator cuff tear surgery and identifying new treatments that could improve muscle regeneration for aging and muscle tears.

PI_NAMEs: HICKS, MICHAEL RYAN (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;Adjuvant Therapy;Affect;Age;age difference;age effect;age related;age-related disease;Aging;aging process;Anti-Inflammatory Agents;Antibodies;Architecture;arm;arm movement;Biological Assay;Biology;Biopsy;California;Cell Aging;Cell Physiology;cell regeneration;cell type;Cells;cellular pathology;cellular targeting;Chronic;Classification;Clinical;clinical practice;Coculture Techniques;cohort;Complex;Cytometry;Defect;deltoid muscle;Dependence;drivers of aging;endogenous stem cells;exhaust;exhaustion;extracellular;Extracellular Matrix;Fatty acid glycerol esters;Fibrosis;Functional disorder;functional status;Gender;gender difference;Genes;Genetic Diseases;Health Personnel;Healthcare Systems;Heterogeneity;high dimensionality;Human;human old age (65+);human tissue;Image;Immune;Impairment;improved;In Vitro;individualized medicine;Inflammation;Inflammatory;injured;Injury;Intervention;joint mobilization;Knowledge;live cell imaging;Measures;Medical;Molecular;molecular pathology;Molecular Profiling;mouse model;Muscle;muscle degeneration;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Natural regeneration;older patient;Older Population;Operative Surgical Procedures;Orthopedics;outcome prediction;paracrine;Pathologic;Pathology;patient population;patient variability;Patients;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Population;Predisposition;Prevention;Process;public health relevance;Quality of life;Recovery of Function;reduced muscle strength;regeneration potential;regenerative cell;Regenerative response;regenerative tissue;Regulation;repaired;Replacement Arthroplasty;Risk Factors;Role;Rotator Cuff;rotator cuff tear;Scientist;senescence;Severities;Shoulder;Signal Transduction;Site;Skeletal Muscle;Stains;stem cell genes;stem cell niche;stem cell population;Stromal Cells;supraspinatus muscle;Surgeon;Tendon structure;Testing;Therapeutic Uses;Thick;Tissue Sample;Tissues;transdifferentiation;treatment planning;Work

PROJECT_TITLE: Cellular mechanisms for the degeneration and aging of human rotator cuff tears

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative The 5-year survival rate of liver cancer patients is as low as 9.9% in the United States and 6.2% in Europe. Nearly 2 billion people worldwide infected with hepatic viral diseases are at risk for developing liver cancer and dying owing to limited therapeutic options. While historically systemic chemotherapy has been the cornerstone to cancer treatment, inability to achieve uniform drug delivery to tumors, collateral toxicity to non- cancerous liver and systemic side-effects have limited progress in the development of novel therapies for liver cancer. We propose a transformative platform technology that uses a catheter based locoregional approach to deliver X-ray visible bioengineered biomaterial, i.e. next generation TACE, to induce a more efficient ischemic cell death within the tumor microvasculature that can be coupled with chemo- and immunotherapy. We believe that our approach will prevent progression of cancer providing time to bridge more patients to the curative liver transplantation and extend lives.

PI_NAMEs: KHADEMHOSSEINI, ALI ;OKLU, RAHMI  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Animal Model;anti-cancer;anti-CTLA4;anti-tumor immune response;Apoptosis;Biocompatible Materials;Biomedical Engineering;Blood Vessels;cancer cell;Cancer Model;cancer therapy;Catheters;Cell Cycle Inhibition;Cell Death;Cessation of life;Chemoembolization;chemotherapy;chimeric antigen receptor T cells;Coupled;Data;Development;Dose;Doxorubicin;Drug Delivery Systems;drug distribution;Drug Kinetics;Elasticity;Engineering;Europe;Evaluation;Fluoroscopy;Formulation;Gel;Gelatin;Goals;Hepatic;Histology;Hydrogels;Image;Immune checkpoint inhibitor;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;Inflammatory Response;Injectable;Ischemia;liquid chromatography mass spectrometry;Liver;liver ablation;liver cancer model;liver cancer patient;Liver neoplasms;liver transplantation;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Modeling;Modulus;Molecular;nano;neoplastic cell;next generation;novel;novel therapeutics;Oncolytic viruses;Oryctolagus cuniculus;Patients;Penetration;Performance;Perfusion;Persons;Pharmaceutical Preparations;prevent;Primary carcinoma of the liver cells;Procedures;programmed cell death ligand 1;programmed cell death protein 1;Property;Public Health;Recurrent tumor;Risk;Roentgen Rays;Safety;side effect;Silicates;Solid;Solid Neoplasm;success;Survival Rate;Technology;technology platform;Testing;Therapeutic;Therapeutic Embolization;Thinness;Time;Tissues;Toxic effect;transcatheter arterial chemoembolization;Travel;tumor;tumor ablation;tumor progression;ultrasound;United States;Virus Diseases;Viscosity;World Health Organization

PROJECT_TITLE: Drug eluting injectable biomaterials for next generation chemoembolization


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Craniofacial birth defects and acquired diseases affecting the craniofacial region through treatment modalities or accidents often cause significant functional, structural, and esthetic damage to the face, mouth, and cranium. Despite recent advances in treatment options, the lack of knowledge in molecular mechanisms controlling craniofacial development and regeneration remains a major obstacle in development of more sophisticated therapies or more effective prevention of these conditions. The goal of this NIDCR Dental Specialty and PhD Program is to educate a diverse and uniquely qualified workforce that will accelerate our possibilities to prevent and treat craniofacial diseases and disorders.

PI_NAMEs: KAARTINEN, VESA M;MISHINA, YUJI  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acceleration;Accidents;Accreditation;Address;Admission activity;Affect;Behavioral Research;Biomedical Research;career;career development;chemotherapy;Cleft Lip;cleft lip and palate;Clinic;Clinical;Clinical Research;clinical training;Complex;Comprehensive Health Care;Congenital Abnormality;Coupled;craniofacial;craniofacial development;cranium;Dental Specialties;Dentistry;Development;Disease;Doctor of Philosophy;Ensure;Environment;Esthetics;experience;Face;Faculty;Firearms;Funding Mechanisms;Goals;Graduate Education;Head and Neck Cancer;Health Sciences;Human;Knowledge;leadership development;medical specialties;Mentors;Michigan;Modality;Molecular;multidisciplinary;National Institute of Dental and Craniofacial Research;Natural regeneration;Operative Surgical Procedures;Oral cavity;Oral health;Patient Care;prevent;Prevention;programs;Qualifying;Radiation therapy;Records;recruit;Research;research and development;Rotation;School Dentistry;Scientific Advances and Accomplishments;Scientist;skills;Students;Training;Training Support;Universities;Work

PROJECT_TITLE: DSPP Scholar Training at the University of Michigan School of Dentistry


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

PHR: Not Required

PI_NAMEs: CONSTANS, JOSEPH I (contact);TRUE, JENNIFER GALA

PROJECT_TITLE: Development and Evaluation of a Veteran-Informed Means Restriction Intervention for Suicide Prevention

STUDY_SECTION_NAME: Innovation Initiative 2[HSN2]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: 7 HILLS PHARMA, LLC

ORG_STATE: TX

PHR: PROJECT NARRATIVE Elderly subjects, aged 65 years and over, show suboptimal responses to influenza vaccination, and are at increased risk of influenza-related morbidity and mortality. While T cell responses have been shown to provide better correlation than humoral responses with respect to immune protection against influenza in the elderly, existing vaccine/adjuvant combinations may not elicit these required functional T cell responses. In this proposal, we aim to demonstrate the effectiveness of influenza vaccination/challenge studies in aged mice with the oral adjuvant 7HP349 that has shown enhancement of both humoral and T cell responses with multiple infectious disease vaccines, and to activate an IND and manufacture cGMP 7HP349 Drug Product to support a future Phase I/IIa clinical study for the improvement of the effectiveness of influenza vaccination in elderly subjects.

PI_NAMEs: DE, SIDDHARTHA ;MARATHI, UPENDRA  (contact);SCHARY, WILLIAM ;SCHOTSAERT, MICHAEL

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adjuvant;age related;aged;Aging;Agreement;aluminum sulfate;American;Animal Model;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;B-Lymphocytes;Biological Assay;Biological Availability;Cell Adhesion;cell motility;Cellular Immunity;Cessation of life;Chagas Disease;Chemistry;Clinical;Clinical Research;Clinical Trials;Communicable Diseases;Control Groups;Cross Reactions;cross reactivity;Cyclic GMP;Data;Defect;Dendritic Cells;Development;Disease;Dosage Forms;Dose;Drug Kinetics;Effectiveness;Elderly;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Equipment and supply inventories;Exposure to;first-in-human;Flow Cytometry;Fluzone;Formulation;Foundations;Future;Guidelines;Hemagglutinin;Hospitalization;Human;human old age (65+);Humoral Immunities;Immune;Immune response;Immune system;Immunity;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;immunological synapse;immunosenescence;improved;Individual;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;Integrin alpha4beta1;Integrin-mediated Cell Adhesion Pathway;Integrins;Intercellular adhesion molecule 1;Life;Ligands;male;manufacture;Measures;Memory;MF59;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Neuraminidase;New Caledonia;old mice;Oral;pandemic disease;pathogen;Patient Compliance;Pharmaceutical Preparations;Phase;pill;Play;Populations at Risk;pre-clinical;pre-Investigational New Drug meeting;preclinical study;programs;Public Health;Recommendation;residence;response;Risk;Role;Safety;safety assessment;safety testing;Schedule;Seasons;Serious Adverse Event;seroconversion;Serum;Shapes;small molecule;Speed;Surrogate Markers;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Time;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine access;vaccine effectiveness;vaccine efficacy;vaccine response;vaccine trial;Vaccines;Vascular Cell Adhesion Molecule-1;Viral;Viral Antigens;Virus;Work;young adult

PROJECT_TITLE: 7HP349, an oral integrin activator to augment effectiveness of pre-exposure influenza vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(11)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Radiation Oncology

ORG_CITY: SANTA MONICA

ORG_NAME: CELESTIAL ONCOLOGY INC.

PHR: Success of the proposed project would lead to the development of a superior replacement for all general- purpose radiotherapy machines with advantages in dose conformity, automation, and throughput. The project will allow completing the system, achieving regulatory clearance, carrying out the first clinical installation and performing a clinical study for lung cancer patients. The final clinical system would revolutionize the field of radiation therapy by allowing precise tumor targeting to be achieved with a quick, flexible robotic system enabling high patient throughput.

PI_NAMEs: SHENG, KE ;YONEMOTO, JAY  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acceleration;Adoption;Algorithms;arm;Automation;Award;Businesses;Cancer Patient;cancer therapy;Certification;Clinic;clinic ready;Clinical;clinical application;Clinical Research;cohort;commercialization;Computer software;design;detector;Development;Disease;Dose;dosimetry;Extravasation;flexibility;Fluoroscopy;Freedom;Funding;Grant;Head;Image;image guided;image guided radiation therapy;imaging modality;improved;innovation;Investments;Life;Linear Accelerator Radiotherapy Systems;Lung Neoplasms;Malignant neoplasm of lung;manufacture;Maps;Marketing;Mathematics;Mechanics;Motion;Names;novel;Oncology;optimal treatments;Organ;Patients;Phase;Preparation;Publications;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radiometry;reconstruction;research and development;response;Risk;Robot;robotic system;Robotics;Roentgen Rays;Series;Site;Small Business Innovation Research Grant;Solid;Source;success;System;Systems Integration;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Time;Translating;Treatment-related toxicity;tumor;United States National Institutes of Health;Validation

PROJECT_TITLE: Bringing 4π radiation therapy to the clinic


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: Project Narrative This Environmental Toxicology and Epidemiology Program trains future leaders in the environmental health sciences (EHS) who accelerate discoveries of how environmental exposures affect human health and promote improvements in public health. The program focuses on translational applications to human disease prevention with training that bridges environmental toxicology (basic research) and epidemiology (population-based research).

PI_NAMEs: BATTERMAN, STUART A (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Epidemiology;environmental toxicology;Postdoctoral Fellow;pre-doctoral;Research;Training Programs

PROJECT_TITLE: Environmental Toxicology and Epidemiology Pre- and Post-Doctoral Research T32 Training Program

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Prevention;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PI_NAMEs: MACKINNON, DAVID P (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Applications Grants;Bayesian Method;Behavioral Mechanisms;Big Data;Biological Models;Communication;Complex;computer program;Consultations;cost;Data;Data Analyses;Data Collection;data integration;data space;design;Development;dynamic system;Ecological momentary assessment;Educational workshop;Effectiveness;Etiology;Evaluation;Feedback;Funding;Grant;improved;Individual;Individual Differences;innovation;interest;Intervention;Investigation;Link;Literature;longitudinal design;Machine Learning;Measurement;Measures;Mediating;Mediation;Mediator;Meta-Analysis;Methodology;Methods;model design;Modeling;multilevel analysis;National Institute of Drug Abuse;novel strategies;Outcome;Persons;Prevention;Prevention program;Prevention Research;Principal Investigator;Procedures;Process;programs;Psychometrics;Publications;Randomized;Recommendation;Research;Research Design;Research Personnel;Residual state;simulation;Statistical Data Interpretation;Statistical Methods;Subgroup;substance use treatment;Testing;theories;therapy design;Time;tool;Translating;treatment research;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Estimating Mediation Effects in Prevention Studies

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Skin Cancer;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Melanoma is the leading cause of skin cancer related death and its incidence continues to rise. Despite the approval of targeted therapies and immune checkpoint inhibitors to treat melanoma, effective treatment options for metastatic disease remain an unmet need. In this proposal, we aim to better understand the crosstalk between tumor cell signaling pathways and immune cells in order to provide the preclinical basis for new therapeutic strategies.

PI_NAMEs: ROSENBAUM, SHEERA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adopted;Adoptive Transfer;anti-PD1 therapy;anti-tumor immune response;bioluminescence imaging;Biopsy;BRAF gene;Cancer Biology;cancer cell;career;CD4 Positive T Lymphocytes;Cell Line;Cells;Cessation of life;checkpoint therapy;Clinical;clinical implementation;Complex;CRISPR screen;Critical Pathways;Critical Thinking;Cutaneous Melanoma;Data;Detection;Disease;effective therapy;experimental study;FDA approved;Fellowship;Flow Cytometry;Foundations;FOXP3 gene;Genes;Goals;Growth;Hematopoietic;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunocompetent;immunodeficiency;Immunodeficient Mouse;immunoregulation;Immunotherapy;in vivo;Incidence;Individual;Infiltration;inhibitor;insight;International;Libraries;Luciferases;Malignant Breast Neoplasm;Malignant Neoplasms;MEKs;Melanoma;Melanoma Cell;Metastatic Melanoma;Modeling;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Organ;Pathway interactions;Patients;PD-1 blockade;Phase;Phenotype;Play;Postdoctoral Fellow;pre-clinical;pressure;Primary Neoplasm;Principal Investigator;Proteins;Regulation;Regulatory T-Lymphocyte;Research;Research Project Grants;Resistance;response;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;Site;skills;Skin Cancer;Solid;symposium;T-Cell Proliferation;targeted treatment;Techniques;Testing;Time;Training;Transcript;transcription factor;Transfection;Transgenic Mice;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor initiation;Tumor Promotion;Up-Regulation;Work;Writing

PROJECT_TITLE: Tumor Intrinsic Regulation of Immune Evasion Pathways in Breast Cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Nutrition

PHR: Narrative The proposed research is relevant to public health as these studies will generate new fundamental knowledge in drug development and may lead to therapeutics against gastrointestinal diseases.

PI_NAMEs: MOON, JAMES J. (contact);NAGRATH, DEEPAK

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Affect;anti-PD-1;anti-PD1 therapy;Biocompatible Materials;Biomedical Engineering;cancer immunotherapy;Cancer Model;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cellular Metabolic Process;Chemosensitization;Colitis;Colon;colon cancer patients;Colorectal Cancer;commensal microbes;Consumption;Data;Dietary Fiber;Disease;Drug Delivery Systems;drug development;efficacy evaluation;Exhibits;Exposure to;fecal transplantation;Formulation;Gastrointestinal Diseases;Gastrointestinal tract structure;Gel;Goals;gut microbiome;gut microbiota;healthy volunteer;Human;human subject;Human Volunteers;immune activation;immune checkpoint blockers;Immune response;immune-related adverse events;Immunity;Immunologic Stimulation;Immunology;Immunotherapy;improved;In Situ;Incidence;Inflammatory Bowel Diseases;Inulin;Knowledge;Lead;Length;manufacturing scale-up;Mediating;Memory;Metabolic;metabolomics;microbial;microbiome;Modeling;mouse model;multidisciplinary;Mus;Nature;new technology;novel therapeutics;Oral;Oral Administration;Oral Ingestion;patient response;patient subsets;Patients;Pharmacologic Substance;Pharmacy (field);Play;prebiotics;prevent;Probiotics;Production;programmed cell death protein 1;Property;Public Health;Quality Control;Research;Resistance;Role;stem;Structure;Structure-Activity Relationship;Study Subject;success;T cell differentiation;T cell response;T-Lymphocyte;Therapeutic;tool;Toxic effect;Translating;tumor;Volatile Fatty Acids

PROJECT_TITLE: Biomaterials for modulating the gut microbiome for immune activation

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;HIV/AIDS;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Opiate use/abuse is at epidemic rates in the United States, and is even more prevalent in people living with HIV (PLWH) compared to the uninfected general population. Opiate intoxication and withdrawal from opiates produce distinct physiological responses, each with negative consequences that include adherence to antiretroviral drugs, viral suppression, immune and cognitive functions. In this application we propose that opiate use in PLWH results in a chronic activation of the brains NLRP-inflammasome system and the associated innate immune system with consequent upregulations inflammatory cytokines and complement proteins that tag neuronal synapses for elimination.

PI_NAMEs: HAUGHEY, NORMAN J (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;Adherence;Anti-Retroviral Agents;Astrocytes;Binding;Biogenesis;biological adaptation to stress;Biological Models;Brain;Capsid Proteins;Cessation of life;Chronic;cognitive function;Complement;complement system;Complex;Corpus striatum structure;cytokine;Dendritic Spines;density;Disease Progression;Drug Addiction;drug withdrawal;Epidemic;Excision;extracellular vesicles;Fentanyl;fentanyl self-administration;General Population;Heroin;HIV;HIV Envelope Protein gp120;IL18 gene;immune function;Impaired cognition;improved;In Vitro;in vivo Model;Infection;Inflammasome;Inflammation;Inflammatory;Innate Immune System;Intoxication;Learning;Leucine-Rich Repeat;Liver;marenostrin;Memory;Memory impairment;Metabolism;Microglia;Modification;Morphine;morphine administration;Mus;neuron loss;Neurons;Nucleotides;Opioid;opioid abuse;opioid use;opioid withdrawal;oxidation;Pathway interactions;Pattern recognition receptor;Persons;Phagocytosis;Pharmaceutical Preparations;Physiological;Population;prevent;Primary Cell Cultures;Proteins;Reactive Oxygen Species;repaired;response;Role;Self Administration;Synapses;System;tat Protein;Testing;Transgenic Mice;Transgenic Organisms;United States;Viral;Virus Diseases

PROJECT_TITLE: NLRP inflammasome directed activation of the innate immune system produces synaptic damage in EcoHIV infected mice self-administering fentanyl

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Childhood Obesity;Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE This project will characterize the functional genome of human term placenta down to the single cellular level in order to reveal how the complex interplay of the in utero environment and genetic variation may impact birthweight and early childhood growth and obesity. Identifying these molecular pathways will be useful in defining prevention or intervention strategies that can be implemented early to alleviate long-term disease burden.

PI_NAMEs: CHEN, JIA ;MARSIT, CARMEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Abnormal placentation;Address;Adult;Affect;Age;Alleles;Atlases;Automobile Driving;Biological Markers;Birth;Birth Weight;Body mass index;burden of illness;Cardiovascular system;Cell Nucleus;Cells;Child Health;Childhood;cohort;Cohort Studies;Communities;Complex;Data;Data Set;design;Development;Disease;disorder risk;early childhood;Early Intervention;Environment;Environmental Risk Factor;Epigenetic Process;Etiology;Evaluation;Fetal Development;functional genomics;Gene Expression;Genetic;Genetic Induction;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Growth;Growth and Development function;Health;health disparity;Human;Human Development;improved;in utero;Inherited;innovation;insight;instrument;Intervention;Investigation;Knowledge;late life;Lead;Life;Link;Mediating;Mediation;Mediator;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Biology;National Institute of Child Health and Human Development;Neonatal;New Hampshire;non-genetic;Obesity;obesity in children;offspring;Organ;Outcome;Pathway interactions;Perinatology;Placenta;Placentation;Population;Population Heterogeneity;Populations at Risk;postnatal;predictive modeling;Pregnancy;Pregnancy Outcome;prenatal;Prevention strategy;Process;programs;prospective;Protocols documentation;Proxy;Quantitative Trait Loci;Reproducibility;Research;Research Priority;Resolution;Resources;Rhode Island;risk stratification;RNA Splicing;Role;Signal Transduction;single nucleus RNA-sequencing;Solid;Stress;Structure;Systems Biology;Technology;Testing;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Translations;Variant;Work

PROJECT_TITLE: Characterizing the functional genomic atlas of human placenta and unveiling the prenatal programming of early-life development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The considerable public health burden of psychostimulant use disorders creates a priority for intervention. Accumulating evidence indicates that the long-lasting cellular effects of cocaine use include astrocytes and neuron-astrocyte communication within the brain’s reward circuitry. This proposal seeks to determine how persistent cocaine-dependent adaptations in astrocyte structure affect critical functional roles of astrocytes and drug seeking behavior.

PI_NAMEs: REISSNER, KATHRYN JOANNA (contact)

PROJECT_TERMS: Abstinence;Acute;Adenosine;Adenosine A1 Receptor;Affect;Animal Behavior;antagonist;Area;Astrocytes;Atrophic;Automobile Driving;Behavior;Behavioral;Biosensor;Brain;Calcium Signaling;Cell model;Cell Physiology;Cells;Chronic;Cocaine;cocaine craving;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Communication;Coupled;craving;Data;designer receptors exclusively activated by designer drugs;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Drug abuse;drug seeking behavior;Drug Targeting;Electrophysiology (science);Exhibits;experimental study;fluorescence imaging;Functional disorder;G-Protein-Coupled Receptors;Glutamates;Goals;GTP-Binding Proteins;high resolution imaging;Homeostasis;Image;Impairment;In Situ;in vivo;Incubated;inhibitor;Intervention;Intravenous;Knowledge;Label;Ligands;male;Measures;Mediating;multimodality;neural;neural circuit;neuroadaptation;Neuroglia;Neurons;Neurophysiology - biologic function;novel;Nucleus Accumbens;patch clamp;Pathologic;Pathology;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;presynaptic;prolonged abstinence;Public Health;Pump;Rat Transgene;Rattus;receptor;Regulation;response;reward circuitry;Role;Saline;Self Administration;Signal Transduction;Slice;stimulant use disorder;Structure;Substance Use Disorder;Surface;Synapses;synaptic depression;synaptic inhibition;Synaptic Transmission;Testing;Time;treatment strategy

PROJECT_TITLE: Functional consequences of cocaine self-administration on astrocytes

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Treatment advances in psychosis are limited by the use of phenomenology-defined diagnoses based on symptomatic outcomes, rather than by neurobiological constructs monitored by quantitative characteristics. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) uses biomarkers to define psychosis subgroups with the goal of testing the advantages of B-SNIP biomarkers for diagnostic and therapeutic decisions, consistent with principles in the NIMH Strategic Plan. We propose to test Biotype1 psychosis subgroup with clozapine, and predict a differential clinical response to clozapine compared with Biotype2, marked by normalization of IEA, cortical attractor network activity and an advantage over usual antipsychotic drugs, establishing low IEA in Biotype1 as a predictive biomarker for clozapine efficacy.

PI_NAMEs: GERSHON, ELLIOT S (contact);KEEDY, SARAH K

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: anti-depressive agents;Antipsychotic Agents;Bacterial Artificial Chromosomes;Biological Markers;biotypes;blind;Blinded;Blood;Characteristics;Chemistry;Clinical;Clinical assessments;clinical efficacy;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;Clozapine;Cognition;Communities;Complex;Consent;deviant;Diagnosis;Diagnostic;Dose;Double-Blind Method;Dropout;Drug Monitoring;Electrocardiogram;Electroencephalography;forging;Future;Goals;Grant;improved;Individual;Libraries;Measures;Monitor;Myocarditis;National Institute of Mental Health;neural;Neurobiology;Neutropenia;Outcome;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;phenomenological models;Phenotype;phenotypic biomarker;Physicians;Physiological;Plasma;predictive marker;Preparation;proband;Prognosis;Psychoses;Randomized;recruit;Regimen;research clinical testing;Resistance;response;Risperidone;Saccades;Safety;Sampling;Schedule;Schizophrenia;Seizures;side effect;Site;Specific qualifier value;stimulus processing;Strategic Planning;Subgroup;symptomatic improvement;Symptoms;Testing;Therapeutic;Time;Titrations;treatment duration;volunteer;Work

PROJECT_TITLE: 2/5-Clozapine Response and Biomarker Correlates in Low-IEA Biotype-1


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Many critical issues in environmental health research are quantitative in nature (for example assessment of dose-response relationships) and involve collection and analysis of empirical data subject to various sources of error and uncertainty. Statistical expertise is vitally needed for this task, yet the supply of statisticians interested in environmental health research has lagged the demand. Our program aims to fill that gap.

PI_NAMEs: THURSTON, SALLY W (contact)

PROJECT_TERMS: Biometry;Environmental Health;Training

PROJECT_TITLE: Training in Environmental Health Biostatistics


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cachexia;Chronic Obstructive Pulmonary Disease;Clinical Research;Dietary Supplements;Genetics;Lung;Nutrition;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE STATEMENT  Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the United States with mortality continuing to rise despite advances in medicine. Cachexia, a form of muscle wasting, is a debilitating co-morbidity whose prevalence increases with severity of COPD. Elucidating mechanisms of mitochondrial dysfunction in COPD cachexia has the potential to aid the development of therapeutics targeting mitochondrial oxidative stress.

PI_NAMEs: MCDONALD DONNELLY, MERRY-LYNN NOELLE (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: absorption;alpha-tocopherol transfer protein;Aminolevulinate;Antioxidants;Binding;Biological Assay;Biopsy;Body Weight decreased;Bronchoalveolar Lavage;Cachexia;Cancer Cachexia;Cancer Patient;Cardiovascular system;Cause of Death;Chronic Obstructive Pulmonary Disease;cigarette smoke;Citrate (si)-Synthase;cohort;comorbidity;Cytochromes;Data;Defect;Electron Transport;Enzymes;Etiology;Ferritin;Framingham Heart Study;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genomic variation;Health Expenditures;Heart;Heme;heme biosynthesis;Homeostasis;Impairment;Intake;Investigation;Iron;Iron Regulatory Protein 2;Jackson Heart Study;Life;Liver;Lung;Malignant Neoplasms;Mediating;Mediation;Medicine;Messenger RNA;Mitochondria;mitochondrial dysfunction;mitochondrial therapeutics;mortality;mortality risk;mRNA Translation;Multi-Ethnic Study of Atherosclerosis;Muscle;muscle form;Muscular Atrophy;Myoblasts;National Heart, Lung, and Blood Institute;non-smoker;Oxidative Stress;Particulate Matter;Pathway interactions;patient population;Patients;Phenotype;Plasma;Population;preservation;Prevalence;Production;Proteins;public health relevance;Quantitative Trait Loci;Reactive Oxygen Species;recruit;Regulation;Research;Response Elements;Risk Factors;Role;Serum;Severities;Severity of illness;Skeletal Muscle;Smoke;Smoker;Smoking;System;Testing;therapeutic development;Thinness;Toxic effect;Trans-Omics for Precision Medicine;Transcript;transcriptome sequencing;transcriptomics;Translational Repression;Translations;United States;Variant;Vitamin E;Vitamins;whole genome;Work

PROJECT_TITLE: COPD cachexia: deciphering the impact of antioxidants, iron and mitochondrial function using 'omics approaches

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Felder et al_R25_2022_Project_Narrative_FINAL Today’s undergraduate biomedical engineering students require training to translate and commercialize design innovations to impact society. Here, we introduce a project development pipeline for distributed, interdisciplinary, and sustainable student-driven innovation. The goal of this proposal is to enhance biomedical engineering student education and facilitate longitudinal project development through interdisciplinary collaboration. 1

PI_NAMEs: BROWNE, MICHAEL GORDON;FELDER, ANTHONY E. (contact);KOTCHE, MIIRI

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Address;Awareness;Biomedical Engineering;Businesses;Clinical;clinical effect;Clinical Skills;Collaborations;commercialization;Communication;comparative;Competence;design;design verification;Development;Device Designs;Device or Instrument Development;Discipline;Education;Educational Curriculum;Educational process of instructing;Empathy;Engineering;Ensure;experience;Familiarity;Fostering;Goals;health care delivery;Immersion;improved;innovation;Intellectual Property;interdisciplinary collaboration;interest;Medical;Medical Students;Medicine;Modernization;novel;Outcome;Output;Performance;Physical Capacity;Physicians;Process;product development;programs;prototype;Public Health;Publications;Readiness;skills;Societies;student participation;student training;Students;success;Surveys;Techniques;Technology;Technology Transfer;tool;Training;Translating;undergraduate student;Validation;verification and validation;Work

PROJECT_TITLE: A distributed and interdisciplinary pipeline for sustainable student-driven innovation


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ZARIA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: AHMADU BELLO UNIVERSITY

PHR: Project Narrative Human African trypanosomiasis causes and estimated 1.35 million loss of disability-adjusted life year (DALY) annually, and 65 million people are at risk infection. In addition, the region records an annual loss of 4. 5 billion US dollars resulting from millions of cattle, camels, and small ruminants being killed by animal trypanosomiasis. To alleviate such heavy burden created by this disease on Africa, this project is designed to find novel compounds that ablate energy production in the disease pathogens and killing them. The success of this project will generate new classes of safe and effective anti-Trypanosoma drug candidates and contribute to health and economic development of Africa.

PI_NAMEs: BALOGUN, EMMANUEL OLUWADARE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Ablation;Adopted;Africa;Africa South of the Sahara;African;African Trypanosomiasis;alternative oxidase;Animals;Biological Assay;Blood;California;Camels;Categories;Cattle;Cells;Cessation of life;Chemicals;Collaborations;Communicable Diseases;Data;design;Development;disability-adjusted life years;Disease;Doctor of Philosophy;drug candidate;Drug Design;drug development;drug discovery;Drug Interactions;Economic Development;Endemic Diseases;Enzymes;Failure;Future;Generations;Genetic;global health;Glucose;glucose metabolism;Glycerol Kinase;Glycolysis;Grant;Health;Human;Human Activities;Infection;infection risk;inhibitor;innovation;Journals;kinase inhibitor;Lead;Libraries;Luciferases;Macronutrients Nutrition;Mentors;Metabolism;Methods;Microscopy;Molecular Target;multidisciplinary;nanomolar;new therapeutic target;Nigeria;novel;novel therapeutics;Organism;Outcome;Parasites;pathogen;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Pharmacy Schools;Phase;Populations at Risk;Prevention;Production;professor;Proteins;Publishing;rational design;Records;Reporting;repository;Ruminants;Science;screening;side effect;small molecule libraries;Starvation;Stream;Structure;Structure-Activity Relationship;success;System;Therapeutic;three dimensional structure;Toxic effect;transmission process;Trypanocidal Agents;Trypanosoma;Trypanosoma brucei brucei;Trypanosomiasis;Tsetse Flies;Universities;Vaccination;Work;X-Ray Crystallography

PROJECT_TITLE: Multi-target approach to rational design of novel therapeutics for human African trypanosomiasis

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative: Hair cells and supporting cells are required for auditory function. Their loss causes permanent hearing loss. The proposed research aims to test the roles of reprogramming factors and reveal the mechanisms of mitotic and non-mitotic regeneration of supporting cells and hair cells in mice.

PI_NAMEs: CHENG, ALAN GI-LUN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;activating transcription factor 3;Adult;Affect;Auditory;Automobile Driving;Bioinformatics;Biological Models;Biophysics;Candidate Disease Gene;cell age;Cell Differentiation process;Cell Maturation;cell motility;Cell Nucleus;Cell Proliferation;cell regeneration;Cell Size;Cells;Cochlea;Cochlear Implants;Coin;combinatorial;Data;Development;Diphtheria Toxin;Electric Capacitance;Electrophysiology (science);enhancing factor;Epithelium;experimental study;Fingerprint;Genes;Genetic;genetic signature;GFI1 gene;Goals;Hair;hair cell regeneration;Hair Cells;Hearing;Hearing Aids;hearing impairment;Homer 1;Human;Image;improved;In Situ Hybridization;In Vitro;in vitro regeneration;in vivo;Inner Hair Cells;Inner Supporting Cell;insight;Knowledge;Labyrinth;Lateral;LGR5 gene;live cell imaging;Mammals;Maps;Maturation-Promoting Factor;Measures;mechanotransduction;Medial;Membrane;migration;Mitotic;Modeling;Molecular;molecular marker;mouse model;Mus;Natural regeneration;Neonatal;neonatal mice;nerve supply;novel;novel marker;Organ of Corti;Otologic Surgical Procedures;Outer Hair Cells;overexpression;Pathology;Pattern;permanent hearing loss;Persons;Population;postsynaptic;presynaptic;progenitor;programs;Proliferating;Property;Proteins;Publishing;Radial;rat Pres protein;Research;Role;Sensorineural Hearing Loss;Sensory Hair;single nucleus RNA-sequencing;SLC17A8 gene;spatiotemporal;Structure;Supporting Cell;Synapses;Technology;Testing;transcription factor;transcriptome;transcriptome sequencing;transdifferentiation;Transgenic Mice;Viral;Work

PROJECT_TITLE: Molecular basis of mammalian cochlear regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-W(02)M]


ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH DNA variants leading to enhanced activity of the LRRK2 gene product are associated with an increased risk of Parkinson's disease, whereas decreased activity of LRRK2 due to mutation or loss of expression recently has been reported in breast and lung cancers as well as in mesothelioma, a treatment resistant-tumor causally linked to asbestos-induced inflammation and tissue damage. LRRK2 plays a role in several cellular signaling pathways, one of which (NFAT signaling) is implicated in both inflammation/immune response and the process by which normal cells are transformed into cancer cells. In this project, we will use a combination of cell biological and mouse model approaches to determine if LRRK2-mediated interactions with NFAT play significant roles in asbestos-induced inflammation, mesothelioma formation, and the environment surrounding the tumor, with the long-term goal of ascertaining if LRRK2 can serve as a useful biomarker for stratifying patients for precision therapies.

PI_NAMEs: TESTA, JOSEPH R. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Acceleration;Amphiboles;Asbestos;Binding;Biological;Biological Markers;Biological Models;body cavity;calcineurin phosphatase;Calmodulin;cancer cell;carcinogenesis;carcinogenicity;Cell Line;Cell Nucleus;cell transformation;Cells;checkpoint therapy;Clinical;Complex;CSNK1A1 gene;Cytosol;Development;Disease;Disease Management;disorder prevention;Dissociation;DNA;Environment;Exposure to;Family;Family Cancer History;Fiber;Future;gene product;Genes;Genetic Transcription;genome sequencing;Germ-Line Mutation;Goals;Heterozygote;Human;Immune response;improved;in vivo;Individual;Inflammation;Inflammatory;Interphase Cell;Link;LRRK2 gene;Malignant Breast Neoplasm;Malignant mesothelioma;Malignant neoplasm of lung;Malignant Neoplasms;Malignant Pleural Mesothelioma;Mediating;Mesothelioma;Molecular Biology;Molecular Conformation;mouse model;Mus;Mutation;Normal Cell;novel;novel strategies;nuclear factors of activated T-cells;Nuclear Translocation;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathogenesis;Pathway interactions;patient stratification;Patients;Pericardial cavity;Peritoneal;Phosphorylation;Phosphotransferases;Play;Pleural;Pleural Mesothelioma;Precision therapeutics;Predisposition;Process;Protein Dephosphorylation;protein expression;Public Health;Reactive Oxygen Species;Refractory Disease;Reporting;Resistance;response;Rest;Risk;Role;Siblings;Signal Pathway;Signal Transduction;Somatic Mutation;Specimen;Stimulus;Susceptibility Gene;Testing;Therapeutic;Thick;Thinness;Tissues;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;Variant;whole genome;Wild Type Mouse

PROJECT_TITLE: Role of the Parkinson's susceptibility gene LRRK2 in NFAT-mediated malignant mesothelioma tumorigenesis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Narrative - Overall Poor math competence elevates risk for health problems, because it compromises educational and employment opportunities and thus presages long-term underemployment and frequent unemployment. Addressing these risks will require integration of basic research on early math development with the development of multisystemic interventions that target core quantitative skills and knowledge.

PI_NAMEs: GEARY, DAVID C (contact)

PROGRAM_OFFICER_NAME: MANN KOEPKE, KATHY M

PROJECT_TERMS: Achievement;Address;Attitude;Basic Science;Behavior;career;Characteristics;Child;Cognitive;Cognitive Science;Collaborations;Competence;Complex;decision research;Development;Early Intervention;Education;educational atmosphere;Employment;Employment Opportunities;Environment;experience;Family;follow-up;formal learning;Foundations;graduate student;Health;Home;Home environment;improved;Individual;Individual Differences;insight;Intervention;Intervention Studies;juvenile delinquent;Knowledge;Leadership;Learning;Learning Disabilities;learning strategy;Life;Literature;Longitudinal Studies;mathematical ability;mathematical difficulties;mathematical learning;Mathematics;mathematics disability;Mentors;next generation;Nursery Schools;Parents;Pattern;Policy Research;Postdoctoral Fellow;programs;Public Policy;Readiness;Reporting;Research;Research Personnel;Research Project Grants;Risk;risk prediction;Risk Reduction;Sampling;Schools;skills;student participation;Students;System;systemic intervention;teacher;Time;Training;Underemployment;Unemployment;Variant;Work

PROJECT_TITLE: Overview: Multisystemic Approach to Early Math Development and Math Learning Disability


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Mental Health;Pediatric;Social Determinants of Health

PHR: Narrative - Research Poor math competence contributes to elevated risks for physical and mental health problems, because it compromises educational and employment opportunities and thus presages long-term underemployment and frequent unemployment. These risks emerge before children start formal schooling and thus amelioration will require an understanding of the multiple factors that influence early math development.

PROJECT_TERMS: Anxiety;Attitude;Behavior;Characteristics;Child;cognitive ability;Collaborations;Competence;Complex;Development;Education;educational atmosphere;effective intervention;Employment;Employment Opportunities;Environment;experience;Family;formal learning;Foundations;Future;Home;Home environment;improved;Individual;Individual Differences;Intervention;juvenile delinquent;Knowledge;Learning;Learning Disabilities;learning strategy;Life;Longitudinal Studies;mathematical ability;mathematical difficulties;mathematical learning;Mathematics;mathematics disability;Mental Health;Names;Nursery Schools;Outcome;Parents;Pattern;physical conditioning;Preparation;Preschool Child;programs;Readiness;Reporting;Research;Research Project Summaries;Risk;risk prediction;Risk Reduction;Sampling;Schools;skills;student participation;Students;System;systemic intervention;teacher;therapy design;Time;Underemployment;Unemployment;Variant

PROJECT_TITLE: Research Strategy: Multisystemic Study of Early Mathematics Development


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Mental Health;Pediatric;Social Determinants of Health

PHR: Narrative - Leadership Poor math competence elevated risks for health problems, because it compromises educational and employment opportunities and thus presages long-term underemployment and frequent unemployment. Developing interventions to address these risks will require learning disability researchers to be trained on understanding and assessing the multiple factors that influence early math development.

PROJECT_TERMS: Address;Adopted;Area;Attitude;Basic Science;Behavior;Characteristics;Child;Code;cognitive ability;Cognitive Science;Competence;contextual factors;Data;Decision Making;Development;Disability research;econometrics;Education;educational atmosphere;effective intervention;Employment;Employment Opportunities;expectation;experience;Exposure to;Family;formal learning;Formulation;Future;Government;Government Agencies;graduate student;Health;Home;Home environment;improved;Individual;Individual Differences;Intervention;Intervention Studies;juvenile delinquent;Leadership;Learning;Learning Difficulty;Learning Disabilities;Life;Literature;Longitudinal Studies;mathematical ability;mathematical difficulties;mathematical learning;Mathematics;mathematics disability;Mentors;Methods;next generation;Nursery Schools;Outcome;Parent-Child Relations;Parents;Pattern;Policies;Policy Research;Postdoctoral Fellow;professor;Public Policy;Readiness;Reporting;Research;Research Personnel;Risk;Risk Reduction;Schools;Short-Term Memory;skills;student participation;Students;systemic intervention;teacher;Training;Underemployment;Unemployment;Variant;Videotape;Work

PROJECT_TITLE: Leadership: Training Young Learning Disability Researchers


NIH_SPENDING_CATS: Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The interactions between epithelial cells and the extracellular matrix are crucial for epithelial function during lung development. We have identified extracellular matrix integrin receptors, α6β1 and α6β4 integrins, that are required for normal fetal lung development. In this proposal, we will determine the mechanisms whereby α6β1 is required for airway branching and define the mechanisms whereby α6β4 regulates airway epithelial cell differentiation and function, which may lead to new approaches to promote lung development and health.

PI_NAMEs: PLOSA, ERIN J (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Adhesions;airway epithelium;airway obstruction;Basement membrane;Binding;bone morphogenetic protein receptors;cell behavior;Cell Differentiation process;Cell Physiology;Cells;Cessation of life;Cilia;cilium biogenesis;Collagen;Critical Pathways;Data;Defect;Development;Developmental Biology;ECM receptor;Epithelial Cells;Epithelium;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Fetal Lung;Functional disorder;Gene Expression;Genes;Genetic;Hemidesmosomes;Histologic;Human;human disease;Impairment;In Vitro;Integrin alpha3beta1;Integrin alpha6beta4;Integrin Binding;Integrins;Intermediate Filaments;Keratin;kinetosome;Laminin;Ligands;Link;LoxP-flanked allele;Lung;lung development;lung developmental disorder;lung health;migration;Minor;Morphogenesis;Mus;Mutation;Neonatal;novel;novel strategies;Organ;Organogenesis;Pathway Analysis;Pathway interactions;Perinatal mortality demographics;Phenotype;Phosphorylation;Play;Primary Cell Cultures;Proliferating;Pulmonary Emphysema;pulmonary hypoplasia;receptor;receptor expression;reconstitution;Regulation;Reporting;Role;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure;support network;Testing;Tissues;Tracheal Epithelium;transcription factor;Transmission Electron Microscopy

PROJECT_TITLE: Integrins in the Developing Lung

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Microbiome;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases;Sepsis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The Great Lakes Clinical Center (GLCC) of the ARDS, Pneumonia and Sepsis (APS) Consortium, consisting of the University of Michigan, Henry Ford Hospital, the University of Cincinnati, and the University of Chicago, is proposing a rich, consortium-wide collection of clinical data and biomarker specimens of patients hospitalized with ARDS, pneumonia, and sepsis which will provide investigators with a broad opportunity to identify endotypes and subphenotypes of these conditions and better inform future clinical trials. The GLCC will screen, enroll, and collect data and biospecimens on a cohort of more than 1,000 hospitalized patients with these conditions at our 4 sites, including data from follow-up at 3, 6 and 12 months. In addition, we propose a Center-specific study that will (Aim 1) identify the pathways by which gut and respiratory microbiota participate in the acute development and trajectory of sepsis, ARDS, and pneumonia and (Aim 2) determine the microbial and metabolic pathways by which gut microbiota influence long-term recovery after these conditions.

PI_NAMEs: DICKSON, ROBERT PICKETT;HYZY, ROBERT C (contact);PRESCOTT, HALLIE CHRISTINE

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Antibiotics;aspirate;Bioinformatics;Biological;biological heterogeneity;Blood;Body Composition;Catchment Area;Chest imaging;Chicago;Clinical;clinical biomarkers;clinical care;clinical center;Clinical Data;clinical heterogeneity;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Collection;Communicable Diseases;Communication;cost;Critical Care;Critical Illness;Curettage procedure;cytokine;Data;Data Collection;Databases;Development;Discipline;Disease;DNA;Early Mobilizations;Emergency Medicine;endotracheal;Enrollment;Ensure;Event;experience;Feces;follow-up;functional status;Future;Geography;gut microbiome;gut microbiota;Health system;Healthcare;Heterogeneity;hospital readmission;Hospitalization;Hospitals;Hybrids;Hyperoxia;Image;Immunology;improved;indexing;Infection;innovation;Intervention;Leadership;Life;long term recovery;Longitudinal cohort study;Longterm Follow-up;Lung;Measures;Mediating;Mediator;Medicine;Metabolic;Metabolic Pathway;Methodology;Michigan;microbial;Microbiology;microbiome;Molecular;Morbidity - disease rate;mortality;Nasal Epithelium;novel;observational cohort study;Observational Study;Outcome;Pathway interactions;Patient observation;Patient-Focused Outcomes;Patients;Persons;Pharmacy facility;pharyngeal swab;Phenotype;Physical Function;Pneumonia;Positioning Attribute;Prevention;Process;prospective;Protocols documentation;Pulse Oximetry;Qualifying;Recovery;Research;Research Personnel;respiratory microbiota;Respiratory System;response;RNA;Role;sample collection;Scientific Inquiry;Sepsis;septic patients;Severity of illness;Site;skin color;Source;Specimen;Survivors;Syndrome;targeted treatment;Techniques;Telephone;Therapeutic;Time;transcriptomics;Universities;Variant;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Great Lakes Clinical Center of the Acute Respiratory Distress Syndrome, Pneumonia and Sepsis (APS) Consortium


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Alcoholism, Alcohol Use and Health;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Racial and Ethnic Minority Health Research;Rare Diseases;Sepsis;Substance Misuse

PHR: Project Narrative and Relevance ARDS, mortality. and commonality phenotypes ultimately pneumonia, and sepsis are common critical illness disorders with significant associated morbidity and There is substantial heterogeneity in these critical illness disorders, and the mechanisms of injury recovery are not well understood. The goal of this consortium is to unravel this heterogeneity and identify  in subgroups of patients with ARDS, pneumonia, or sepsis. Once common ubgroups or are identified, personalized therapies can be discovered that will be effective for specific groups, resulting in improved outcomes for patients with these three disorders. s

PI_NAMEs: AGGARWAL, NEIL RAJ;JANSSEN, WILLIAM ;MOSS, MARC  (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Advisory Committees;alcohol effect;alcohol use disorder;Alcohols;American;Biological Process;Black race;Blood;Caring;Cells;Clinic;Clinical;clinical center;Clinical Research;clinically relevant;cohort;Colorado;commune;Communities;Community Hospitals;comorbidity;Complex;Critical Illness;data acquisition;Data Collection;Diagnosis;diagnostic criteria;Disease;drug of abuse;Endothelial Cells;Enrollment;Ensure;Epidemiology;ethnic difference;experience;follower of religion Jewish;Foundations;Functional disorder;Funding;gender difference;Goals;Health;Heterogeneity;Hispanic;Hospitalization;Hospitals;Human Resources;Immune response;Immunophenotyping;improved;improved outcome;Indigenous;individual variation;Inflammatory Response;Infrastructure;injury recovery;innovation;Institution;Intensive Care Units;Interdisciplinary Study;Latinx;Leadership;Letters;Link;Location;Lung;Medical center;member;Modeling;Modification;Mononuclear;Morbidity - disease rate;mortality;Mosses;multidisciplinary;nerve conduction study;neuromuscular;novel;Outcome;Outpatients;Participant;participant enrollment;patient subsets;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Phase;Phenotype;Pneumonia;Predisposition;Prospective cohort;Protocol Compliance;Protocols documentation;Publishing;racial difference;Recording of previous events;Recovery;recruit;Reporting;Research;Research Infrastructure;Research Personnel;research study;Rural;Rural Community;rural counties;Science;Seminal;Sepsis;sepsis induced ARDS;septic patients;Severities;Sex Differences;Societies;Survivors;survivorship;targeted treatment;Techniques;Time;transcriptome sequencing;Translational Research;United States National Institutes of Health;Universities;urban area;ward

PROJECT_TITLE: Colorado APS Clinical Center


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: San Jose

ORG_NAME: SCIOGEN, LLC

PHR: Narrative Development of a novel RSV vaccine based on the G protein. The vaccine candidate protected RSV infection in the animal models. We propose to conduct process development and preclinical studies to advance the candidate toward human clinical trial.

PI_NAMEs: LI, SHENGQIANG  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Adult;Affinity;aged;analytical method;Animal Model;Animals;Antibodies;Antibody titer measurement;Antigenic Diversity;attachment protein G;Attenuated Vaccines;Autopsy;Betaretrovirus;Binding;Binding Proteins;Biological;Biological Assay;Blood Chemical Analysis;Blood specimen;Body Weight;cell bank;Cells;cGMP production;chemokine receptor;Child;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Vaccines;Cotton Rats;Cyclic GMP;Cytoplasmic Tail;Data;Deposition;design;Development;Disease;disorder prevention;Dose;Elderly;Engineering;Enzyme-Linked Immunosorbent Assay;Evaluation;Female;Fermentation;food consumption;Foundations;Future;GTP-Binding Proteins;Hematology;Heparin;Histopathology;Human;Immunization;Immunize;immunogenicity;Infant;interest;Intramuscular Injections;Investigational Drugs;Investigational New Drug Application;Laboratories;Lower Respiratory Tract Infection;Lung;manufacture;manufacturing process;manufacturing process development;Maternal Age;maternal vaccination;Membrane Glycoproteins;method development;Modeling;Mus;novel;offspring;Organ Weight;Oryctolagus cuniculus;Phase;Phase I Clinical Trials;Play;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Pregnancy;Process;product development;Proteins;Protocols documentation;Qualifying;rational design;receptor;Recombinant Vaccines;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Risk Reduction;Role;Running;Safety;Small Business Innovation Research Grant;Target Populations;Testing;Time;Tissues;Toxic effect;Toxicology;Universities;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;vaccine immunogenicity;vaccine safety;Vaccines;Variant;Viral;Viral Load result;Virus;Work

PROJECT_TITLE: Novel G protein-based RSV vaccine


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Working memory and the ability to generate timed motor responses are essential for carrying out most daily tasks, and impaired in many neurological and psychiatric conditions. Yet, the brain regions, activity patterns, and learning rules that drive working memory and timing are not understood. Here we propose that the brain often multiplexes both forms of information, and we will use a novel behavioral task along with computational and experimental methods to test this hypothesis.

PI_NAMEs: BUONOMANO, DEAN V (contact);GOLSHANI, PEYMAN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Multiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Precision Medicine;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Obstructive sleep apnea (OSA) is a common problem with many underlying mechanisms and various different consequences. We are working on the approach that understanding why someone has sleep apnea could affect how best to treat that individual, but also may have an impact on what problems the disease might cause. By understanding sleep apnea mechanisms better we hope to improve the individualized care of patients who are suffering from this condition and prevent OSA complications.

PI_NAMEs: MALHOTRA, ATUL  (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: actigraphy;Address;Adherence;Affect;Aging;Alternative Therapies;Anatomy;Apnea;Arousal;arterial tonometry;burden of illness;cardiometabolism;Cardiovascular system;Clinical;clinical practice;Clinical Trials;Cognition;Continuous Positive Airway Pressure;Data;Diagnosis;Dilator;Disease;Drowsiness;efficacious treatment;endophenotype;endothelial dysfunction;Endothelium;Eszopiclone;experience;falls;Functional disorder;Goals;heart disease risk;Heart Diseases;Hypercapnia;hypnotic;Hypoxemia;improved;inattention;Individual;individualized medicine;insight;Intervention;Laboratories;Lead;Measurement;Measures;Mediating;men;Metabolic;Methods;middle age;Muscle;Neurocognitive;Newly Diagnosed;Obesity;Obstructive Sleep Apnea;Outcome;Oxygen;pain perception;pandemic disease;Patients;Pattern;Performance;personalized care;personalized medicine;Persons;Pharyngeal structure;Phenotype;Physiological;Polysomnography;Population;positive airway pressure;precision medicine;predicting response;Predisposition;Prevalence;prevent;primary outcome;Process;Randomized;randomized trial;Recurrence;Reporting;Research;Respiration Disorders;response;Risk;Risk Factors;sedative;Severities;Severity of illness;Sleep;Sleep Apnea Syndromes;supplemental oxygen;symptom cluster;symptomatic improvement;Symptoms;Testing;Therapeutic;treatment as usual;United States National Institutes of Health;vehicular accident;vigilance;Woman

PROJECT_TITLE: Sleep Apnea Endophenotypes: One Size Does Not Fit All

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Choroidal atrophy and loss of choriocapillaris are key pathological events of age-related macular degeneration and are associated with the disease progression. The homeostasis of the choroidal tissue relies on the retinal pigment epithelium (RPE), although the underlying mechanisms are unclear. In this proposal, we will characterize how some of the newly identified RPE signaling proteins can regulate the function of choroidal endothelial cells and contribute to choroidal degeneration.

PI_NAMEs: CHEN, YAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: age related;Age related macular degeneration;aged;Aging;aging related;Angiopoietin-2;Atrophic;autocrine;Blindness;Blood Vessels;Bruch's basal membrane structure;Cell Separation;Choroid;Clinical;CMV promoter;Complex;cytokine;DARPP;Data;Defect;Deposition;Digestion;Disease;Disease Progression;Docking;Dropout;Drusen;Elderly;Endothelial Cells;Epithelial Cells;Event;extracellular vesicles;Eye;Fatty Acids;Flow Cytometry;FRAP1 gene;Functional disorder;functional loss;gain of function;Genes;Genetic;Genetic Variation;glucose metabolism;Goals;Histopathology;Homeostasis;Human;Hyperactivity;Impairment;induced pluripotent stem cell;Inflammation;insight;Integrins;Knock-out;Knockout Mice;Link;lipid metabolism;Lipids;Literature;Measures;Mediating;Metabolic;Molecular;mouse model;Mus;Neurons;novel;ophthalmic examination;overexpression;Pathologic;Pathway interactions;PECAM1 gene;Persons;Phagocytosis;Phosphoproteins;Phosphorylation;Photoreceptors;Predisposition;prevent;Production;Proto-Oncogene Proteins c-akt;Research;Retina;Side;Signal Pathway;Signal Transduction;Signaling Protein;Stress;Structure of retinal pigment epithelium;subretinal injection;TEK gene;Testing;Therapeutic Intervention;Thinness;TIE-2 Receptor;Tissues;TSC1 gene;Up-Regulation;uptake;Virus

PROJECT_TITLE: Aberrant RPE mTORC1 signaling in dysregulation of choroid homeostasis


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Hematology;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative There is currently no simple non-fasting blood test that can be used to diagnose gestational diabetes. In this project we will adjust the hemoglobin A1c blood test to account for changes in red blood cells in pregnant women. The goal of the project is to develop a way to accurately find women who are at risk for complications from high blood sugar in pregnancy using hemoglobin A1c.

PI_NAMEs: HIGGINS, JOHN MATTHEW;POWE, CAMILLE ELISE (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accounting;Adopted;adverse outcome;adverse pregnancy outcome;Affect;Age Distribution;Birth trauma;Blood;Blood Glucose;Blood Tests;Cell Cycle Kinetics;clinical practice;cohort;Complete Blood Count;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Diabetes Mellitus;Diagnosis;Diagnostic;Discipline of obstetrics;Dystocia;Erythrocytes;Fasting;Ferritin;Gestational Age;Gestational Diabetes;glucose monitor;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Hematology;Hemoglobin concentration result;High Risk Woman;Hyperglycemia;Hypertension;improved;Individual;Investigation;Link;maternal hyperglycemia;Maternal-fetal medicine;Measurement;Measures;Metabolic;Methods;Modeling;Modernization;modifiable risk;Monitor;Mothers;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal Hypoglycemia;Neonatal Jaundice;Neonatal Mortality;offspring;OGTT;Outcome;Participant;Population;Predictive Value;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnant Women;Reproducibility;Research Personnel;Reticulocyte count;Risk;screening;Shoulder;stillbirth;Testing;Time;Time Study;Training;validation studies;Variant;virtual;Woman;Work

PROJECT_TITLE: Glycemic Observation Using A1C for Gestational Diabetes Diagnosis

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The goal of this Proteogenomic Data Analysis Center (PGDAC) is to elucidate the regulatory molecular and cellular complexity underlying tumors by employing multiomics and network-based systems learning on CPTAC proteogenomic data. Our team brings together extensive expertise in systems learning and proteomics data modeling. The project will generate valuable resources including: (1) high-confidence candidate biomarkers and drug targets; (2) new knowledge of cancer biology that involves integrated genomics, transcriptomics, and proteomics; and (3) new bioinformatics tools that will aid in the mining, visualization, and interpretation of large-scale and complex cancer-related datasets.

PI_NAMEs: MA'AYAN, AVI ;WANG, PEI  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Address;Algorithms;Antineoplastic Agents;assay development;bioinformatics tool;Biological;Biological Assay;biomarker discovery;biomarker identification;Biomedical Research;Cancer Biology;cancer biomarkers;cancer therapy;candidate marker;cell type;clinically relevant;Collaborations;Collection;Communities;Complex;Computer software;computerized tools;Computing Methodologies;crowdsourcing;Data;Data Analyses;data analysis pipeline;data imputation;data integration;data modeling;data portal;data quality;Data Set;Databases;design;Disease;Disease Outcome;disease phenotype;disorder subtype;DNA;DNA Sequence Alteration;Drug resistance;Drug Targeting;Ensure;Fostering;Genes;Genomics;Germ-Line Mutation;Goals;Immune;immune activation;Immune Evasion;Immunologist;Immunophenotyping;Immunotherapy;improved;Individual;insight;Investigation;Knowledge;Label;Learning;Literature;machine learning prediction;Malignant Neoplasms;Mass Spectrum Analysis;member;Methods;Methylation;Mining;Modeling;Molecular;Multiomic Data;multiple omics;multiple reaction monitoring;Mutation;neoplastic cell;Network-based;novel;Oncologist;Online Systems;open source;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Physicians;precision medicine;predictive marker;Process;programs;protein biomarkers;Proteins;proteogenomics;Proteomics;Quality Control;Research;Resources;RNA;Sampling;Scientist;Set protein;Shapes;Signal Transduction Pathway;small molecule;Software Tools;Statistical Data Interpretation;success;System;Systems Biology;task analysis;Testing;Therapeutic;Tissues;tool;Transcript;transcription factor;transcriptome;transcriptomics;Translating;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;user friendly software;user-friendly;Visualization;web app;web services;web-based tool;Work

PROJECT_TITLE: Proteogenomic translator for cancer biomarker discovery towards precision medicine


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Mitochondrial dysfunction is a key contributor to reduced resilience and degeneration that leads to a decline in quality of life in the older adults. Despite intense research efforts, there remains uncertainty around the nature of the mitochondrial dysfunction with age that presents a barrier to developing targeted interventions. The proposed experiments take advantage of newly developed tools to quantify changes in the protein interactions in the mitochondria to generate new insights into the specific mechanisms underlying mitochondrial dysfunction in both mouse models and human aging.

PI_NAMEs: BRUCE, JAMES EDWARD;MARCINEK, DAVID J. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Activity Cycles;Acute;Address;Adult;Age;age related;age related changes;Age related pathologies;aged;Aging;alpha ketoglutarate;ATP Synthesis Pathway;Biological Assay;Biopsy;Calcium;Cardiovascular system;catalase;Chemicals;Citric Acid Cycle;Complex;crosslink;Data;Electron Transport;experimental study;functional decline;Functional disorder;Genes;Glutamate Dehydrogenase;Glutamate Metabolism Pathway;Glutamates;Heart;Homeostasis;Human;human subject;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;Intervention;knock-down;Lead;Link;Maps;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Mobility decline;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Mitochondria;Myocardium;Nature;neuromuscular;novel;Nucleic Acid Regulatory Sequences;old mice;older adult;Organ;Organelles;Oxidation-Reduction;Peptides;Permeability;Phosphorylation;Play;Positioning Attribute;Production;protein complex;Protein Conformation;Proteins;Quality of life;Regulation;Research;resilience;Respiration;Role;Site;Skeletal Muscle;SOD2 gene;Stress;System;Testing;Tissues;tool;Translating;Uncertainty;young adult

PROJECT_TITLE: Aging Mitochondrial Interactome

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: My laboratory is dedicated to developing new methods of immunotherapy for cancer. We have developed methods to superactivate natural killer cells, and prevent them from becoming inactivated, which are highly promising for treating malignancies that are not controlled well by T cell therapies. The approach also activates anti-tumor T cell responses potently. The data suggest that these therapies work in concert with existing (checkpoint) therapies to provide better tumor control. Our plan is to dissect the mechanisms that underlie the effectiveness of the therapy. Furthermore, we will systematically investigate these approaches in mouse models of cancer as preliminary evidence for testing in human patients. These studies will provide new avenues of therapy for patients with treatment-resistant cancer. 1

PI_NAMEs: RAULET, DAVID H (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Activated Natural Killer Cell;Address;Agonist;Animals;Antigen Presentation;antigen processing;antitumor effect;Antitumor Response;cancer immunotherapy;Cancer Model;Cancer Patient;cancer recurrence;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cells;checkpoint therapy;Clinical Trials;Combined Modality Therapy;comparative;Complement;CPG-oligonucleotide;cytokine;Cytotoxic T-Lymphocytes;Data;Dedications;desensitization;Disease remission;effective therapy;Effectiveness;exhaustion;Granzyme;Human;I-antigen;Immunotherapy;Interferons;Interleukin-2;Laboratories;Ligands;Malignant Neoplasms;MC38;Mediating;Methods;Methylcholanthrene;Modeling;Molecular;mouse model;Mus;Mutation;Natural Killer Cells;neoantigens;neoplastic cell;Outcome;Patients;prevent;Proteins;Recurrent tumor;Refractory;refractory cancer;Regimen;Resistance;response;Role;Sarcoma;STING agonists;Stress;synergism;System;T cell response;T cell therapy;T-Lymphocyte;Testing;Therapeutic;therapy resistant;tool;transcriptomics;Treatment Efficacy;tumor;Variant;Work

PROJECT_TITLE: Mechanisms underlying combination therapy mobilizing NK cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE    Glioblastoma is a form of malignant brain tumor with poor prognosis. The tumor cells are highly heterogeneous  and  involve  a  complex  microenvironment  that  includes  both  neoplastic  and  non- neoplastic  brain  cells.  In  this  proposal, we use acute tissue slices generated from patient- derived brain tumor samples and orthotopic mouse  models  that  recapitulate  the  cellular  features  of  these  complex  tumors,  combined  with  single- cell  analysis,  to  determine the effects of drugs and drug combinations that target specific subpopulations of cells in the tumors  and surrounding brain.

PI_NAMEs: BRUCE, JEFFREY N (contact);CANOLL, PETER ;SIMS, PETER ALAN

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acute;Affect;Aftercare;Animal Model;anti-tumor immune response;Astrocytes;Brain;Brain Neoplasms;cell transformation;cell type;Cells;Chemoresistance;chemotherapy;Clinical Trials;Complex;Convection;cytokine;Cytotoxic agent;Data;Dinucleoside Phosphates;Drug Combinations;Drug Delivery Systems;Drug Screening;Drug Targeting;drug testing;Etoposide;Excision;Flow Cytometry;Funding;Glioblastoma;Glioma;Human;Human Resources;Immune;immune modulating agents;Immune Targeting;Immunocompetent;immunogenic;immunogenic cell death;Immunotherapy;improved;Individual;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Interferons;Magnetic Resonance Imaging;Malignant Glioma;Malignant neoplasm of brain;Measures;Mesenchymal;Microglia;Modeling;Molecular;molecular phenotype;Molecular Profiling;mouse model;Mus;Myeloid Cells;Nature;neoplastic;neoplastic cell;neuro-oncology;Neurons;novel drug combination;novel strategies;Oligodendroglia;Operative Surgical Procedures;patient derived xenograft model;Patients;Periodicity;Pharmaceutical Preparations;Phenotype;Population;Positioning Attribute;preservation;Production;Productivity;Prognosis;Proliferating;Recurrence;Recurrent tumor;Reporting;Resected;response;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;Slice;Specimen;STING agonists;success;targeted treatment;Testing;Time;Tissues;tool;Topoisomerase Inhibitors;Topotecan;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Variant

PROJECT_TITLE: Single Cell Analysis of the Infiltrative Margins of Glioblastoma and Post Treatment Recurrence

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep problems. We will employ a longitudinal neuroimaging study design and leverage a well-characterized intergenerational cohort of Puerto Ricans to address prior literature's limitations. This will be the first study to use infant neuroimaging to disassociate the effects of prenatal pollution exposure from those of postnatal pollution exposure, adversity and disadvantage, and offspring genetic risk for ADHD.

PI_NAMEs: LUGO-CANDELAS, CLAUDIA I (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Accounting;actigraphy;Address;Air;Air Pollution;Attention deficit hyperactivity disorder;Behavior;Behavior assessment;Brain;Child;Child Health;Childhood;cohort;Corpus Callosum;Data;Development;Diameter;Disadvantaged;Disparate;Environmental Exposure;Epidemiology;epidemiology study;Family;Female;fetal;fine particles;follow-up;frontal lobe;Generations;Genetic;Genetic Risk;Heritability;Home;Human;IL17 gene;Impairment;indexing;infancy;Infant;Inflammation;inflammatory marker;Inflammatory Response;intergenerational;Interleukin-6;Intervention;Interview;Knowledge;Link;Literature;Magnetic Resonance Imaging;male;Measures;Mediating;Mental disorders;mobile sensor;Mothers;neighborhood disadvantage;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neurotoxicity;Newborn Infant;offspring;Outcome;Participant;Particulate Matter;Pattern;Phenotype;pollutant;Pollution;poor sleep;postnatal;preclinical study;predictive modeling;Predisposition;Pregnancy;prenatal;prenatal influence;Prevention;Puerto Rican;Recording of previous events;Reporting;Research;Research Design;Risk;Role;Running;Scanning;sex;Sleep;Sleep Deprivation;sleep difficulty;Sleep Disorders;Sleep disturbances;Socioeconomic Status;socioeconomics;spatiotemporal;Substance abuse problem;Symptoms;Testing;Time;Toddler;transmission process;United States National Institutes of Health;white matter;Work;Youth

PROJECT_TITLE: Prenatal air pollution and neurodevelopment: a longitudinal neuroimaging study of mechanisms and early risk for ADHD in Puerto Rican children

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The Open Health Imaging Foundation (OHIF) Viewer is a free, professional-grade, open source, web-based medical imaging viewer and application framework that our team has created for the cancer community. OHIF has been widely adopted by hundreds of imaging informatics projects in cancer research and beyond to visualize and quantify disease within patients’ imaging exams. The current proposal will enhance and sustain the platform to expand its image visualization and analysis capabilities, create user-friendly deployment methods, and provide developer, end user, and regulatory support to help researchers better evaluate the nature of cancer disease progression and response to treatment.

PI_NAMEs: HARRIS, GORDON J (contact)

PROGRAM_OFFICER_NAME: ESPEY, MICHAEL G

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;anti-cancer research;Awareness;base;Breast;Cancer Center;cancer imaging;Cancer Research Infrastructure;Categories;Client;clinical practice;clinical translation;Clinical Trials;cloud based;Cloud Computing;Collaborations;Communities;Computer software;Computers;Custom;Data;Data Set;Data Sources;design;Development;Development Plans;Digital Imaging and Communications in Medicine;Disease;Disease Progression;Documentation;Dose;Ensure;Environment;experience;Feedback;flexibility;Focus Groups;Fostering;Foundations;Friends;Functional Imaging;Funding;Funding Agency;Goals;Grant;Guidelines;hackathon;Health;Hospitals;Image;Image Analysis;image registration;image visualization;Imaging Device;imaging informatics;imaging modality;implementation process;improved;Industry;Informatics;Infrastructure;innovation;Internet;Libraries;Longevity;machine learning framework;Malignant Neoplasms;Maps;Masks;Medical Imaging;meetings;Methods;microscopic imaging;molecular imaging;Monitor;multimodality;Nature;novel;Online Systems;open source;outreach;Patient imaging;Positron-Emission Tomography;Privatization;Production;prototype;Radiation therapy;Research;Research Personnel;Research Project Grants;Resources;Series;Side;Site;Slide;Structure;symposium;System;Technology;TensorFlow;tomosynthesis;tool;Training;Translating;Translations;transmission process;treatment response;trend;Update;usability;user-friendly;Visualization;web platform;web-based tool;web-enabled;webinar

PROJECT_TITLE: Extensible Open Source Zero-Footprint Web Viewer for Cancer Imaging Research


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative. Cytomegalovirus infection can disrupt placental function, causing intrauterine growth restriction and fetal demise. Using a combination of trophoblast stem cell culture and a guinea pig model of congenital infection, this project will investigate whether trophoblast differentiation and placental development sensitize the placenta to infection-associated injury early and late in gestation.

PI_NAMEs: BIERLE, CRAIG JOHN (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: adverse pregnancy outcome;Affect;Animal Model;anti-microbial peptide;Anti-viral Response;antiviral immunity;Area;Biological Assay;Cavia;Cell Culture Techniques;Cell Differentiation process;cell dimension;Cell Line;cell type;Cells;Chorion;Circulation;Complement;congenital cytomegalovirus;congenital infection;CRISPR screen;CRISPR/Cas technology;Cytomegalovirus;Cytomegalovirus Infections;cytotrophoblast;Decidua;Derivation procedure;Development;Down-Regulation;Embryo;Environment;exosome;experimental study;fetal;Fetal Growth Retardation;First Pregnancy Trimester;Follow-Up Studies;Gene Deletion;Gene Expression;Genes;Genetic Transcription;Guinea pig cytomegalovirus;guinea pig model;Histopathology;Host Defense;Human;Immune;Immune response;Immunologics;immunopathology;implantation;In Vitro;in vivo;Infection;Infection prevention;Infiltration;Injury;Interferons;Longitudinal Studies;Maternal-Fetal Exchange;Methodology;model development;Modeling;Multipotent Stem Cells;Mutagenesis;Organoids;Outcome;paracrine;Pathogenesis;Pattern;permissiveness;physical separation;Placenta;placental infection;Placentation;Play;Predisposition;Pregnancy;Productivity;Proliferating;Resistance;Resolution;response;Role;Series;stem;stem cell population;stillbirth;Syncytiotrophoblast;targeted treatment;Testing;therapy design;Time;transcriptomic profiling;transcriptomics;trophoblast;trophoblast stem cell;two-dimensional;Villous;Viral;Viral Load result;Viral Physiology;Virus Diseases;Virus Replication

PROJECT_TITLE: Trophoblast development and placental susceptibility to cytomegalovirus infection


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Primary Immunodeficiencies;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: PROJECT NARRATIVE This project strives to understand the mechanisms that regulate protein synthesis. Deregulation of the protein synthesis machinery is associated with diseases such as cancer, ribosomopathies, and metabolic disorders. Uncovering the process of translational control will help to identify novel therapeutic targets.

PI_NAMEs: ORIGANTI, SOFIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Allosteric Regulation;Aminoacyl-tRNA hydrolase;aurora B kinase;Binding;Biochemical;Biological Assay;Biological Models;Biophysics;cancer cell;cancer subtypes;cancer type;Cell Cycle;Cell Nucleolus;Cell Proliferation;Cell Survival;Cellular Assay;Childhood Leukemia;Colon Carcinoma;Complex;Cytoplasm;Data;Deuterium;Disease;Disease Progression;Dissociation;Ensure;Eukaryotic Initiation Factors;Event;experimental study;Generations;Goals;Growth;Growth and Development function;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Human;Hydrogen;Hydrolysis;Impairment;in vivo;Inherited;insight;leukemia;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic Diseases;Methodology;Mitosis;Modeling;Molecular;mouse model;mutant;Mutation;new therapeutic target;novel;overexpression;Pathogenesis;Pathologic;Patients;Peptide Initiation Factors;Phenotype;Phosphorylation;Physiological;Prognosis;Protein Biosynthesis;Protein Deregulation;Quality Control;Regulation;release factor;Ribonucleoproteins;Ribosomal RNA;Ribosomes;ribosomopathy;Role;RPL10 gene;Shwachman-Diamond syndrome;single molecule;Site;Tail;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissue Microarray;Trans-Activators;Translation Initiation;Translation Process;Translations;triple-negative invasive breast carcinoma;Tumor Tissue;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Mechanism and Regulation of eIF6 in Translation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]