NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative The proposed study seeks to develop two instruments used to measure sexual and gender minority (SGM) help-seeking barriers and recovery needs after experiencing gender-based violence (GBV). The proposed research is relevant to public health because unaddressed GBV victimization represents a key driver of SGM health disparities (e.g., suicidality, substance use, depression, HIV transmission) and understanding help-seeking barriers and recovery needs can help improve care linkages and identify additional areas for intervention and survivor support. This project is relevant to NIH's mission because it focuses on improving health for marginalized populations through identifying barriers to GBV treatment access, engagement, and effectiveness, with the goal to inform acceptable interventions to reduce health disparities and improve health outcomes for SGM populations.

PI_NAMEs: SINKO, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adherence;Area;Articulation;Behavioral;biological sex;Caring;Child Abuse;cis-female;cisgender;Clinical;cognitive interview;Collaborations;Communities;community advisory board;community engaged approach;community engagement;Data;Data Set;design;Development;Disability status;Discrimination;disparities in morbidity;Disparity;disparity reduction;Domestic Violence;effective intervention;Effectiveness;Effectiveness of Interventions;Ensure;Ethnic Origin;Ethnography;experience;Face;Foundations;Future;Gender;Gender expansive;Gender Identity;gender minority;gender minority community;gender minority group;gender minority health disparity;gender-based violence;Goals;harassment;Hate;healing;Health;health care settings;Health Disparities Research;health disparity;Health Priorities;Health Services;Health Services Accessibility;help-seeking behavior;Heterosexuals;HIV;improved;Individual;Infrastructure;innovation;instrument;Intervention;Interview;intimate partner violence;Knowledge;lens;Life;Literature;marginalization;marginalized population;Measurement;Measures;Medical;Mental Depression;Mental Health;Methods;Mission;Morbidity - disease rate;mortality;mortality disparity;Murder;nonbinary;Outcome;peer;perceived discrimination;Persons;Play;Policies;Population;Process;Psychometrics;Public Health;Quality of Care;Quality of life;Race;racism;Recovery;Reduce health disparities;Research;Research Project Summaries;Resources;Role;Safety;Sampling;screening;Service setting;Services;Sex Orientation;Sexual and Gender Minorities;sexual assault;sexual minority;sexual minority group;sexual minority men;sexual minority women;Shelter facility;social;Social Work;socioeconomics;Solid;Source;structural determinants;substance use;suicidal;Surveys;Survivors;survivorship;Testing;tool;transgender;transgender women;transmission process;United States National Institutes of Health;Validation;Victimization;Violence;violence victimization;Voice;Work

PROJECT_TITLE: Advancing help-seeking and recovery measures for sexual and gender minority survivors of gender-based violence

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative/Public Health Relevance Statement Oral inflammatory diseases, such as periodontitis, are characterized by progressive destruction of supporting structures, which is mainly attributed to the degeneration of endogenous stem cells. The findings of this proposal will identify a novel cellular mechanism in activating somatic stem cell abilities through repurposing an FDA approved nanoformulation for a new biomedical, clinical application.

PI_NAMEs: CHEN, CHI-DER  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Adult;adult stem cell;Anemia;anti-cancer;Apical;Apoptosis;Architecture;Biological Assay;bone;Bone Marrow;Bone Regeneration;cell behavior;Cell Lineage;Cell Proliferation;Cell Survival;Cells;Chronic Kidney Failure;clinical application;Clinical Research;clinical translation;Coculture Techniques;craniofacial bone;craniofacial tissue;cytokine;cytotoxic;Data;Defect;Dinoprostone;Disease;dosage;Dose;drug candidate;endogenous stem cells;Exhibits;ferumoxytol;Formulation;Goals;Growth;Histologic;Immune;immunoregulation;Impairment;improved;In Vitro;in vivo;Inflammatory;iron oxide nanoparticle;Knock-out;Knockout Mice;Knowledge;Ligature;Lymphocyte;Mediating;Mediator;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Metabolic;migration;Modeling;Molecular;mouse model;Mus;nanoformulation;nanoparticle;Natural regeneration;Neural Crest;novel;novel therapeutics;Oral;orofacial;Osteogenesis;osteogenic;Pathogenicity;Patients;Periodontitis;Play;postnatal;preclinical study;Procedures;Proliferating;Property;public health relevance;Regenerative capacity;Regenerative Medicine;Role;self-renewal;Signal Transduction;stem cell biomarkers;stem cell function;stem cell homeostasis;stem cells;stemness;Structure;subcutaneous;System;Tetracyclines;Therapeutic;tissue regeneration;Tissues;tongue papilla;transcriptome sequencing;translational study;Transplantation;Treatment Efficacy;United States Food and Drug Administration

PROJECT_TITLE: Repurposing Ferumoxytol Nanoparticles to Promote Orofacial Stem Cell Function for Autotherapies

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: This proposal aims to advance the understanding of gene regulatory networks in genomics by developing deep learning models that integrate spatial transcriptomics data. Two aims include developing methods for cell-type specific network estimation that transition between scRNA-seq and spatial transcriptomics, and creating models with spatial regularization to uncover networks at a spatial resolution. These efforts are expected to revolutionize our understanding of cellular functions and tissue organization by incorporating the nuances of individual cells and their spatial context.

PI_NAMEs: WANG, HAOHAN  (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Advanced Development;Biological Process;Brain;cell behavior;Cell Differentiation process;Cell Physiology;cell type;Cells;Collaborations;Data;Data Set;deep learning;deep learning model;Dependence;Development;Dimensions;Disease;Effectiveness;Exhibits;Face;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;genomic data;Genomics;Genotype-Tissue Expression Project;Human BioMolecular Atlas Program;human data;Individual;insight;large datasets;Learning;Life;Location;Machine Learning;machine learning model;Maps;Masks;Methods;Modeling;Molecular;Network-based;Outcome;Pathogenesis;Pathway interactions;Pattern;Phenotype;Positioning Attribute;Prefrontal Cortex;Process;Research;Resolution;response;single-cell RNA sequencing;spatial integration;spatial relationship;Structure;Techniques;Technology;Thinness;Tissue Sample;Tissues;tool;training data;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Toward Deep Learning Techniques for Cell-Type and Spatial Resolution Estimation of Regulatory Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Diabetes;Genetics;Human Genome;Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Understanding cellular responses to harmful alterations in the in utero environment is critical for the development of therapies which prevent congenital defects. We will exploit in vitro differentiations of kidney organoids and the openly manipulatable environment to interrogate how the pregestational diabetic milieu alters developmental programs, providing novel insights into how disruptions to normal development result in physiological consequences. Our studies will extend the current utility of kidney organoids and open up prospects for the development of interventional strategies that prevent kidney congenital defects.

PI_NAMEs: O'BRIEN, LORI L (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Affect;Amalgam;ATAC-seq;blood filtration;Body System;cell type;Cells;Child;Chromatin;Chronic Kidney Failure;Congenital Abnormality;congenital anomalies of the kidney;congenital anomaly;Congenital Heart Defects;Critical Pathways;Derivation procedure;Development;Developmental Process;Diabetes Mellitus;diabetic;diabetic embryopathy;differentiation in vitro;DNA Sequence Alteration;Endowment;Environment;Exposure to;fetal;Fetal Kidney;Filtration;Foundations;Future;Gene Expression Profile;Generations;Genetic;Genetic Diseases;Glucose;Goals;Growth and Development function;Health;Heart;Human;Human Biology;human induced pluripotent stem cells;Hyperglycemia;in utero;In Vitro;in vivo;induced pluripotent stem cell;Injury;insight;Intervention;Investigation;Kidney;Kidney Diseases;Methodology;Modeling;mortality;mouse model;Mus;nephrogenesis;nephron progenitor;Nephrons;novel;Organ;Organoids;Physiological;Play;podocyte;Population;Predisposition;prenatal exposure;prevent;progenitor;Program Development;programs;Quality of life;Research;response;Risk;Role;single-cell RNA sequencing;Structural defect;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;Tissues;treatment strategy

PROJECT_TITLE: Use of kidney organoids to investigate developmental programs and the effects of fetal exposures

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CINCINNATI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Based on extensive human brain injury data research (athletes, soldiers, and non-sport related brain impacts), we hypothesized that injury-induced cell-specific dysregulation in mitochondria bioenergetic and metabolic functions transforms them into neurodegenerative factories that control the onset of acute neuroinflammation and neuronal damage and the widespread long-AD- like pathology. We will use novel genetically engineered brain cells with fluorescent mitochondria to determine cell-specific injury-induced alterations in mitochondria function and potential molecular mechanisms responsible for AD-like degeneration spread through dysfunctional mitochondrial uptake by neighboring cells over time. The outcome of this project will provide 1) a chronologic understanding of cell-specific mitochondria alterations in acute and chronic phases of brain injury progression, 2) potential molecular mechanisms that drive mitochondria alterations and further neurodegeneration progression, 3) a causal understanding of the cell-specific contribution to mitochondrial dysfunction-driven AD-like neurodegeneration progression.

PI_NAMEs: LIAUDANSKAYA, VOLHA  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acute;Alzheimer's Disease;Annexins;Award;Binding;Biochemical;Bioenergetics;Brain;brain cell;Brain Injuries;Cells;Cessation of life;Chronic;Chronic Phase;chronic traumatic encephalopathy;Chronology;Communication;Communities;Complex;Data;Data Collection;diagnostic biomarker;diagnostic development;disability;Disease;Engineering;Event;experimental study;extracellular;Failure;gene therapy;Genetic;Genetic Engineering;Human;human data;Image;in vitro Model;Injury;Integrins;Life;Medical;Metabolic;Metabolism;MicroRNAs;Mitochondria;mitochondrial dysfunction;Molecular;Morbidity - disease rate;Movement;Nerve Degeneration;Neurobiology;neurochemistry;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;novel;novel strategies;Outcome;Parkinson Disease;Pathology;Phenotype;Research;Research Personnel;Resolution;response;response to brain injury;reuptake;Risk Assessment;Risk Factors;Soldier;spatiotemporal;TBI Patients;TBI treatment;Testing;Time;tissue injury;Tissues;transcriptomics;Traumatic Brain Injury;uptake;Validation

PROJECT_TITLE: The cell-specific neurodegenerative potential of mitochondria post-traumatic brain injury

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our project aims to develop child-tailored quantitative imaging tools for assessing treatment effects in children with cancer while ensuring the lowest possible radiation exposure. We are testing novel diffusion-weighted magnetic resonance imaging and positron emission tomography technologies for therapy response assessment of pediatric cancers. We anticipate that child-tailored imaging tests will introduce a new, safer, more efficient, and more accurate generation of imaging exams for children that can be widely applied to interrogate health and disease without the risk of radiation-induced secondary cancers later in life.

PI_NAMEs: DALDRUP-LINK, HEIKE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Adult;Aftercare;Anatomy;anti-cancer research;Artificial Intelligence;artificial intelligence algorithm;Assessment tool;Attention;Biological Markers;Cancer Detection;cancer diagnosis;cancer imaging;cancer immunotherapy;cancer therapy;chemotherapy;Child;Clinical;clinical application;clinical imaging;convolutional neural network;Data;Data Set;Development;diagnostic accuracy;Diagnostic Neoplasm Staging;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dose;Ensure;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Generations;Glucose;Goals;Health;Image;image reconstruction;imaging approach;Imaging Device;Imaging Techniques;Imaging technology;Immunotherapy;improved;Injections;ionization;Ionizing radiation;irradiation;leukemia;Life;Link;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of thyroid;Malignant Neoplasms;Measurement;Measures;Medical Imaging;Metabolic;Metabolism;minimally invasive;Mission;Monitor;MRI Scans;nanoparticle;National Cancer Institute;neoplasm immunotherapy;novel;novel imaging technology;Oncology;Organ;Outcome;Patient imaging;Patients;Pediatric Hospitals;Pediatric Neoplasm;Pediatric Oncology;pediatric patients;Pharmaceutical Preparations;Physiology;Population Study;Positioning Attribute;Positron-Emission Tomography;Predisposition;Protons;quantitative imaging;Radiation;Radiation Dose Unit;Radiation exposure;radiation risk;Radioactive;radiological imaging;Research;Research Personnel;response;Risk;Scanning;Second Primary Cancers;Sensitivity and Specificity;Staging;Standardization;Techniques;Technology;Testing;Therapeutic;Thoracic Radiography;Time;treatment effect;treatment response;tumor;tumor metabolism;tumor progression;uptake;whole body imaging;X-Ray Computed Tomography

PROJECT_TITLE: Advanced Imaging Tools to Assess Cancer Therapeutics in Pediatric Patients

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative (max: 3 sentences) Spinal cord injury (SCI) can result in permanent loss of mobility or sensation below the injury. There are approximately 300,000 Americans living with SCI and 18,000 new cases every year. This proposal uses new genetic technologies and a mouse model of SCI to efficiently compare many candidate combination therapies that could potentially enhance the regeneration of injured neurons and improve functional recovery after SCI.

PI_NAMEs: CASTLE, MICHAEL ;LU, PENGZHE  (contact);TUSZYNSKI, MARK H.

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Adult;American;Animals;axon regeneration;Bar Codes;Biological Models;c-myc Genes;Caenorhabditis elegans;Candidate Disease Gene;Cells;Central Nervous System;Ciliary Neurotrophic Factor;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combination gene therapy;Combined Modality Therapy;Corticospinal Tracts;CRISPR screen;Databases;Dependovirus;design;DNA;DNA sequencing;dorsal column;Dose;Embryo;Esthesia;experience;expression vector;Family;Future;Gene Combinations;gene therapy;Genes;Genetic;Genetic Screening;genetic technology;Guide RNA;improved;In Vitro;in vivo;in vivo Model;Individual;Injury;knock-down;Knock-out;knockout gene;Lesion;Libraries;Literature;Mediator;Methods;Modeling;Motor Cortex;mouse model;Mus;Natural regeneration;Nerve Crush;nerve stem cell;neuron regeneration;Neuronal Injury;Neurons;new combination therapies;next generation;next generation sequencing;Optic Nerve;Optic Nerve Injuries;overexpression;permissiveness;Plasmids;Prevalence;PTEN gene;rapid technique;Recovery of Function;regenerative;retrograde transport;Rodent;screening;Side;Site;Spinal Cord;Spinal cord injury;Spinal Ganglia;Spinal Injections;Testing;Time;tool;transcription factor;vector genome;Viral Genome

PROJECT_TITLE: Rapid In Vivo Screening of Combination Gene Therapies for Axonal Regeneration after Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: FAIRFAX

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE Human and animal studies of schizophrenia implicate aberrant hippocampal network oscillations as a result of alterations to N-methyl-D-aspartate receptor (NMDAR) GluN2B subunits at excitatory synapses, however, GluN2 subunits regulate NMDAR ionotropic and direct intracellular signaling at excitatory synapses and the independent roles of these different signaling mechanisms have not been investigated with respect to schizophrenia. This pioneering proposal will extend investigation into the neural underpinnings of schizophrenia to the neurotransmitter receptor subunit domain level by exploring of the contributions of distinct GluN2B signaling domains to hippocampal network dynamics and spatial memory. Outcomes will fill important knowledge gaps in what is known of the molecular and physiological bases of schizophrenia, which will revise our understanding of this devastaing disease and enable the creation of novel treatments and potential cures.

PI_NAMEs: DUMAS, THEODORE C (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TITLE: Distinct NMDA receptor signaling domains regulate hippocampal network dynamics

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Natural IgM antibodies are part of the immediate early defense from infections, but their presence also reduces the incidence of autoimmune disease. This grant proposal aims to identify novel genes that regulate the development and/or maintenance of the cells generating these antibodies. Gaining this knowledge is critical for harnessing the potential broad protective powers of this antibody through development of vaccines and/or therapeutics. It may also identify new pathways that can control autoreactive B cells.

PI_NAMEs: BAUMGARTH, NICOLE  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affect;Age;Antibodies;Antibody Formation;Applications Grants;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;biobank;Biological Markers;Biology;Birth;body cavity;Bone Marrow;C57BL/6 Mouse;Candidate Disease Gene;Cell Count;Cell Maintenance;Cell secretion;Cells;Chimera organism;Color;Data Analyses;data mining;Data Set;Development;Developmental Process;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Family;Female;fetal;Flow Cytometry;Follow-Up Studies;Future;Gene Expression Profile;Gene Mutation;Genes;Genetic Screening;genetic signature;Genotype;Goals;Hematopoiesis;Homeostasis;Host Defense;Human;IgG3;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Incidence;Individual;Infection;infection risk;interest;Jaw;Knock-out;Knockout Mice;Knowledge;Leukocytes;Link;Lymphoid;Maintenance;male;Measures;Mediating;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse genome;Mouse Strains;Mus;Myelogenous;natural antibodies;Nature;Neonatal;neonatal period;novel;Pathway interactions;Phenotype;Plasma Cells;Population;Prevention;Process;Production;programs;prophylactic;rare genetic disorder;Reference Values;Regulation;Regulatory Pathway;reverse genetics;Reverse Transcriptase Polymerase Chain Reaction;Role;Serum;Sorting;Source;Spleen;Therapeutic;Tissues;United States National Institutes of Health;vaccine development;Vertebrates

PROJECT_TITLE: Regulation of Natural Antibody-Producing B-1 Cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: || Project Narrative Restoring blood flow to the heart by surgery can be complicated by cells in the blood vessel wall dividing continuously after the surgery, eventually blocking blood flow again. We know that many therapy targets used to stop cells from dividing are found inside the cells, making them difficult to target. Our research aims to define a new type of therapy based on very small antibodies, show that we can make these go inside the cells, and demonstrate that this stops cells from dividing in the blood vessel.

PI_NAMEs: JOHNSTONE, SCOTT R (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Affinity;Amino Acids;Antibodies;Area;Arteries;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;blood damage;Blood flow;Blood Vessels;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;CCNE1 gene;Cell Cycle;Cell Proliferation;Cell Therapy;Cells;cellular engineering;Characteristics;Charge;chemotherapeutic agent;clinically relevant;Complementary DNA;Complex;confocal imaging;Confocal Microscopy;Connexin 43;Data;design;Development;Disease;Disease Progression;E protein;effective therapy;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Epitopes;Etiology;Failure;feeding;Flow Cytometry;Foundations;Fractionation;Future;Generations;healing;High Pressure Liquid Chromatography;Histologic;Human;human model;human tissue;Immune;Immune response;Immunoglobulin G;improved;In Vitro;in vivo;Injections;Injury;innovation;interest;Intervention;Libraries;Ligation;Llama;Measures;Mediating;Mediator;Mission;Modeling;Molecular Sieve Chromatography;Molecular Target;Monoclonal Antibodies;mouse model;Mus;nanobodies;Nanotechnology;National Heart, Lung, and Blood Institute;Nature;neointima formation;novel;Operative Surgical Procedures;Pathologic;Pathway interactions;Peptides;peptidomimetics;Peripheral Blood Mononuclear Cell;pharmacologic;Post-Translational Protein Processing;programs;Proliferating;Property;Proteins;prototype;pulmonary arterial hypertension;Recovery;repaired;Reporter;Research;Research Proposals;response;Role;Saphenous Vein;screening;Site;Smooth Muscle Myocytes;Stents;Surface Plasmon Resonance;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;Time;Tissues;Translational Research;Translations;Vascular Diseases;Vascular regeneration;Veins;Visualization

PROJECT_TITLE: Development of a novel intracellular targeting nanobody that blocks Cx43-mediated pathological proliferation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative  This project will examine the impact of sexual minority stress and post-traumatic stress disorder symptoms on alcohol use using an innovative ecological momentary assessment design. The proposed investigation will carry implications for the reduction of alcohol use, including heavy episodic drinking, by providing information on critical risk factors among bi+ college students. Thus, the proposed research is relevant to the prevention and treatment of alcohol use.

PI_NAMEs: BASTING, EVAN JACOB (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Adult;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol misuse prevention;alcohol prevention;alcohol risk;Alcohols;assigned female at birth;assigned male at birth;Attitude;binge drinking;biological adaptation to stress;Birth;Bisexual;Child Abuse and Neglect;Consumption;coping;design;deter alcohol use;Development;Discrimination;Distress;drinking;Ecological momentary assessment;Economics;Emotional;Event;experience;Exposure to;Fellowship;Female;Gays;Goals;health inequalities;Heterosexuals;Hour;Individual;innovation;internalized stigma;Intervention;intervention program;Investigation;Lesbian;Lesbian Gay Bisexual Transgender Queer;Life;Life Experience;Life Stress;male;minority stress;minority stressor;Modeling;negative affect;pansexual;Persons;Post-Traumatic Stress Disorders;Prevalence;prevent;Prevention;Prevention program;programs;Prospective Studies;Public Health;queer;Recording of previous events;reduced alcohol use;Reporting;Research;Research Personnel;Research Support;Risk;Risk Factors;Self Medication;sexual identity;sexual minority;sexual minority group;sexual minority stress;skills;social;social stigma;stressor;Symptoms;theories;Training;trait;Trauma;trauma exposure;traumatic stress;university student;Violence;Vulnerable Populations;young adult;young adult alcohol use

PROJECT_TITLE: Examining Proximal Associations between Minority Stress, PTSD Symptoms, and Alcohol Use among Bi+ College Students with Trauma Histories

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Regenerative Medicine;Tuberculosis

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), infects one-fourth of the world’s population. Majority of the infected individuals are latently infected (LTBI), of which 5-10% stand a risk of progressing to active TB disease (ATB) during their lifetime. Work proposed here will delineate the cellular mechanisms of protective pathways that mediate Mtb control and TB reactivation aiding in the development of new therapeutics for TB disease.

PI_NAMEs: AHMED, MUSHTAQ  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;Adult;alveolar epithelium;Animal Model;Blood;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;bronchial epithelium;cell type;Clinical;Clinical Trials;Data;Development;Disease;Disease Progression;Epithelial Cells;Evaluation;Exhibits;Histological Techniques;Homeostasis;Human;Immune;Immunity;Individual;Inflammatory Response;Injury;insight;Intervention;Knowledge;loss of function;Lung;lung development;lung regeneration;lung repair;Macaca;Mediating;Modeling;mouse model;Mus;Mycobacterium tuberculosis;Natural regeneration;nonhuman primate;novel;novel therapeutics;pathogen;Pathologic;Pathway interactions;Play;Population;predictive marker;protective pathway;Protein Activation Pathway;protein expression;rational design;Regenerative pathway;Regulation;Regulatory Element;repaired;Reporter;Reporting;Risk;Role;Signal Pathway;Signaling Protein;single cell sequencing;small molecule inhibitor;Structure of parenchyma of lung;Technology;therapeutic development;Therapeutic Intervention;Time;tissue injury;tissue regeneration;tissue repair;transcriptome sequencing;transcriptomics;Tuberculosis;Vaccines;Work

PROJECT_TITLE: Role of Lung Repair and Regeneration Pathways in Tuberculosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Nanotechnology;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Biomarkers that reliably inform the selection of therapy or prognosis for patients with head and neck squamous cell carcinoma (HNSCC) are lacking. Emerging data suggest that analysis of the profiles of small (30-150 nm) extracellular vesicles (sEV), also known as exosomes, in body fluids is a promising approach to the detection of non-invasive biomarkers in cancer, including HNSCC. This project will simultaneously assess the utility of sEV produced by tumor cells (TEX) and sEV produced by non-malignant cells (NTEX) in HNSCC patients’ plasma as biomarkers of prognosis and/or response to therapy.

PI_NAMEs: DIERGAARDE, BRENDA B.;WHITESIDE, THERESA L. (contact);ZANDBERG, DAN PAUL

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: advanced disease;Aftercare;aggressive therapy;anti-PD-1;Antibodies;Biogenesis;Biological Assay;Biological Markers;Body Fluids;cancer biomarkers;Cancer Patient;cancer therapy;carcinogenesis;Cell Separation;Cells;Characteristics;Clinical;clinical development;clinically relevant;Combined Modality Therapy;Data;Defect;Development;Diagnosis;Disease;Disease Progression;disorder control;Effector Cell;exosome;extracellular vesicles;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV positive;HPV-negative head and neck cancer;Immune;Immune checkpoint inhibitor;Immune System Diseases;Immunocompetence;Immunologics;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;ineffective therapies;Leukocytes;Ligands;Link;Malignant Neoplasms;Mediating;Metastatic/Recurrent;Minority;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;nanoflow cytometry;neoplastic cell;Non-Invasive Detection;Non-Malignant;novel;Outcome;Parents;patient prognosis;Patient Selection;patient subsets;Patients;pembrolizumab;Performance;Phenotype;Plasma;Plasma Cells;potential biomarker;Prediction of Response to Therapy;predictive marker;Prognosis;prognosis biomarker;Prognostic Marker;programs;Proteins;Quality of life;Regulatory T-Lymphocyte;Reporting;Resistance;Resolution;response biomarker;Role;Sampling;Selection for Treatments;standard care;standard of care;T-Lymphocyte;Technology;Testing;therapy resistant;Toxic effect;treatment response;Tumor-Derived;Vesicle;Western Blotting

PROJECT_TITLE: Small extracellular vesicles as biomarkers of prognosis and response to therapy in head and neck cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative RNAs perform important regulatory functions that make them attractive as disease biomarkers, therapeutics, or therapeutic targets. This project is aimed at developing user-friendly new technologies for the detection and analysis of various RNAs. Ultimately, these simple and inexpensive techniques will accelerate the pace of discovery in RNA research to the benefit of human health.

PI_NAMEs: HALVORSEN, KEN A (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Adopted;Area;Binding;Biological Assay;Biological Markers;Biology;Biosensing Techniques;Catalytic RNA;centrifuge force microscope;Chemicals;Collaborations;Communities;Complex;cost;Detection;Development;Development Plans;Disease;DNA;Drug Delivery Systems;Environment;FarGo;Health;Human;Individual;innovation;interest;Investments;Knowledge;Methods;Modification;Molecular;Molecular Conformation;nanoscale;Nanostructures;nanoswitch;Nanotechnology;new technology;Nucleic Acids;pandemic disease;Performance;Play;pre-clinical;Productivity;programs;Reagent;Reporting;Research;research and development;RNA;RNA Probes;RNA purification;RNA vaccine;RNA Viruses;Role;Science;single molecule;Structure;Structure-Activity Relationship;success;Techniques;Technology;technology development;Therapeutic;therapeutic target;Thermodynamics;tool;user-friendly;Vision;Work

PROJECT_TITLE: Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnology

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Public Health Relevance Statement (Project Narrative) The goal of this project is to use an emerging medical imaging modality, hyperpolarized 13C MRI, to study metabolic changes in the brain. This work will increase our knowledge about the brain’s metabolism and could ultimately make a significant impact on the clinical management of patients with aging-related neurological diseases.

PI_NAMEs: VLASSENKO, ANDREI G.;VON MORZE, CORNELIUS  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adult;aerobic glycolysis;aging brain;aging related;Bioreactors;Brain;Brain imaging;brain metabolism;brain research;Brain scan;Clinical;Clinical Management;clinical translation;Cognitive;Consensus;Data;Development;Diagnostic;Echo-Planar Imaging;Energy Metabolism;experimental study;Feasibility Studies;Funding;Future;Geometry;glucose metabolism;Goals;Human;human imaging;human subject;Image;imaging approach;imaging modality;imaging study;In Vitro;in vivo;Individual;Injections;Knowledge;Lactate Dehydrogenase;Magnetic Resonance Imaging;Marketing;Medical Imaging;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Methods;Modality;molecular imaging;Nerve Degeneration;Nervous System Disorder;neuroimaging;neuroregulation;open source;Paper;Participant;Pathologic;Pathway interactions;Patients;Physiologic pulse;Positron-Emission Tomography;prototype;public health relevance;Pyruvate;Pyruvate Metabolism Pathway;radio frequency;real-time images;recruit;Reproducibility;Research;research study;Role;Running;Scanning;Series;Signal Transduction;Specificity;success;Technology;Testing;Time;tool;Vendor;Work

PROJECT_TITLE: Feasibility and reproducibility of hyperpolarized 13C pyruvate human brain imaging on a new MRI scanner platform

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Clinical Research;Lung

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Peak lung function is achieved in early adulthood, progressively declines with age, and significantly impacts quality of life. This research will study the effects of normal aging on the ability of lung stretch to increase airway caliber and maximize ventilatory capacity in elderly adults. The findings will generate novel insight into the physiological mechanisms of reduced lung function in the elderly and will have important implications for the clinical interpretation of changes in pulmonary function across the aging spectrum.

PI_NAMEs: HAVERKAMP, HANS CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Adult;age effect;age related;age related decline;Aging;Agonist;Air Movements;Bronchoconstriction;Bronchodilation;Caliber;Clinical;constriction;Coupling;Data;Diameter;Elastic Tissue;Elasticity;Elderly;emerging adult;experimental study;expiration;human old age (65+);Incidence;Inhalation;insight;Legal patent;Link;Lung;Lung Diseases;lung volume;Maximal Expiratory Flow Rate;Maximal Expiratory Flow-Volume Curves;Measurement;methacholine;middle age;normal aging;novel;older patient;Oscillometry;Participant;Persons;Physiological;preservation;pulmonary function;Quality of life;Recording of previous events;Research;Resistance;respiratory smooth muscle;Respiratory System;response;Role;Spirometry;Stretching;Structure;Testing;Total Lung Capacity;Vital capacity;young adult

PROJECT_TITLE: Airway distensibility and lung inflation effects on the maximal expiratory flow volume curve in elderly adults

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE (RELEVANCE) Mutations in GBA1, which encode for the protein glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and emerging evidence suggests that the loss of GCase activity is involved in the onset of these diseases. Despite there is significant interest in developing GCase-targeted therapies for the treatment of these diseases, a lack of methodology for measuring GCase activity in disease-modeling systems hinders progress in developing GCase therapies. The successful completion of our high throughput screening will provide unique drug candidates for these diseases and will provide a new drug screening platform for GBA1-associated PD/DLB and sporadic PD/DLB patients.

PI_NAMEs: KO, HANSEOK  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acceleration;Address;alpha synuclein;Attention;Award;Biological Assay;Biological Models;blood-brain barrier crossing;Budgets;Cell Line;Cell model;Cells;Chemicals;Clinical Trials;cost;cost effective;cost effectiveness;CRISPR/Cas technology;Cytoplasm;Data;Dementia with Lewy Bodies;differentiation protocol;Disease;disease model;dopaminergic neuron;Dose;drug candidate;Drug Screening;Drug toxicity;early onset;efficacy evaluation;efficacy validation;Endoplasmic Reticulum;endoplasmic reticulum stress;Enhancers;enzyme replacement therapy;Enzymes;Exhibits;Fibroblasts;Flow Cytometry;Fluorescence;Funding;Genes;Genetic Models;genetic risk factor;glucosylceramidase;Glucosylceramides;Heat-Shock Proteins 70;high throughput screening;Human;Impairment;improved;In Vitro;in vivo Model;induced pluripotent stem cell;innovation;interest;Lewy Bodies;Libraries;Link;liquid chromatography mass spectrometry;Lysosomes;Macrophage;Measures;Methodology;Mitochondria;Modeling;Molecular Chaperones;mutant;Mutation;nerve stem cell;Neuronal Differentiation;novel therapeutics;Onset of illness;Outcome;Parkinson Disease;Pathologic;Pathology;patient derived induced pluripotent stem cells;patient screening;Patients;pharmacologic;pre-formed fibril;Predisposition;Process;Production;protein expression;Proteins;Recombinants;Research;screening;small molecule;small molecule therapeutics;sporadic Parkinson's Disease;Stains;success;Symptoms;synucleinopathy;System;targeted treatment;Therapeutic;Time;Tissues;Validation

PROJECT_TITLE: Validation of Small Molecule Enhancers of Mutant Glucocerebrosidase 1 Activity

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Hematology;Immunotherapy;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Dendritic cells (DCs) play a critical role in the innate and adaptive immune responses to blood-borne antigens and regulate T cell immunity versus tolerance. Patients with factor VIII (FVIII) and IX (FIX) deficiencies are at risk of developing inhibitory antibodies to factor replacement, however it is unclear whether DCs mediate the differences in FVIII and FIX immunogenicity. The main objectives of this work are to characterize the role of DCs in the innate immune response to FVIII and FIX and to evaluate the impact of factor-DC interactions on adaptive immune responses in hemophilia A and B, respectively.

PI_NAMEs: BATSULI, GLAIVY  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: adaptive immune response;Adsorption;Affect;Allergic;Anaphylaxis;Antibodies;Antibody Formation;Antibody Response;Antigen Presentation;Antigen Presentation Pathway;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;B-Cell Activation;B-Lymphocytes;Blood coagulation;Blood Coagulation Disorders;Blood Vessels;C Type Lectin Receptors;career;career development;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cell Physiology;Cells;Cellular biology;cohort;Complement Activation;Complex;Confocal Microscopy;Dendritic cell activation;Dendritic Cells;Deposition;Development;Development Plans;Disease;Endocytosis;Ensure;Event;Exogenous Factors;Factor IX;Factor VIII;Flow Cytometry;Glycoproteins;Hemophilia A;Hemophilia B;Hemorrhage;Immediate hypersensitivity;Immune response;Immune Tolerance;Immunity;Immunize;immunogenicity;Immunologics;Immunology;In Vitro;Incidence;Individual;Inflammation;Infusion procedures;Inherited;inhibitor;Innate Immune Response;Intraperitoneal Injections;Intravenous infusion procedures;intravenous injection;ITAM;ITGAX gene;ITIM;Laboratories;late endosome;Lecithin;Lipopolysaccharides;Lysosomes;Macrophage;Measures;Mediating;MHC Class II Genes;Microspheres;Molecular Biology;mouse dectin-2;mouse model;Mus;Natural Immunity;Nephrotic Syndrome;neutralizing antibody;Ovalbumin;Patients;Phagocytes;Phagocytosis;pharmacologic;Play;Poly I-C;Polystyrenes;prevent;Process;Property;Proteins;prothrombin complex concentrates;receptor;receptor mediated endocytosis;Research;response;Risk;Role;Sampling;Signal Transduction;Spleen;Subcutaneous Injections;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Techniques;Testing;Training;Translational Research;uptake;Work;XCR1 gene

PROJECT_TITLE: Utilizing Dendritic Cell Biology to Characterize the Innate Immune Response to Blood Coagulation Proteins


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: PROJECT NARRATIVE  The very low birth weight (VLBW) preterm infant, born at 24-32 weeks gestation, is at a critical stage of structural and functional auditory development in a suboptimal environment, and with limited access to speech. By harnessing the existing cohort of VLBW preterm infants, and recruiting age-matched full-term infants, the researchers aim to identify predictors of language growth, including gestational age, health and demographic factors, and initial (0-18 months) language development trajectories, influenced by parent-infant communication patterns, across a period of rapid language emergence typically observed in the second and third years of life. Results from the proposed project will advance our understanding of factors that impact risk and resilience for language growth over time and will provide an evidence base for meaningful clinical and family-based interventions to improve language outcomes, and thus public health, in this at- risk population.

PI_NAMEs: HAY, JESSICA S (contact);NEWNAM, KATHERINE MARIE

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Adult;Age;Age Months;Auditory;Auditory area;auditory pathway;Auditory system;Birth;Birth Weight;Caregivers;Chronology;Clinical;cohort;Communication;comorbidity;Data;Demographic Factors;Development;Early identification;Environment;Equipment;evidence base;Exposure to;Family;Gestational Age;Growth;Health;Health Status;high risk;Hospitalization;improved;in utero;Infant;innovation;Interdisciplinary Study;Intervention;Knowledge;Language;Language Delays;Language Development;language impairment;language outcome;Life;Linguistics;Link;Longitudinal Studies;Loudness;Measurement;Measures;Mechanics;Memory;Neonatal Intensive Care Units;neural;neural circuit;Neural Pathways;Neurocognitive;Neurologic;novel;Oral;Outcome;parent-child communication;parental influence;Parents;Pattern;peer;Phase;Population;Populations at Risk;Positioning Attribute;Predictive Factor;Pregnancy;Premature Infant;Process;promote resilience;Public Health;recruit;Research Personnel;resilience;respiratory;Risk;Risk Factors;Risk Marker;Scientific Advances and Accomplishments;skills;sound;sound frequency;Speech;Speech Delay;speech processing;Statistical Models;Structure;Survival Rate;Temporal Lobe;Testing;Time;United States;Uterus;Very Low Birth Weight Infant;Vocabulary;vocalization;Vulnerable Populations;word learning

PROJECT_TITLE: Predictive Factors in Language Development Trajectories Over the First 3 Years of Life: Harnessing an Existing Preterm Cohort

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICIs) are less effective at reducing tumor burden in bone metastatic patients and coincide with musculoskeletal toxicities including bone loss and fractures. Interactions between the tumor, bone, and immune microenvironments that might be contributing to this clinical observation are not well understood. This proposal investigates the novel concept that ICIs suppress bone formation and enhance bone resorption, increasing patient fracture risk, and therefore have the potential to transform clinical care and outcomes for patients receiving ICIs.

PI_NAMEs: JOSEPH, GWENYTH JEAN (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Adoptive Transfer;Affect;Antitumor Response;Biomechanics;bisphosphonate;bone;bone health;bone loss;Bone Marrow;Bone Marrow Neoplasms;bone mass;Bone neoplasms;Bone remodeling;Bone Resorption;Bone Resorption Stimulation;bone strength;bone turnover;cancer therapy;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Lineage;Cell Separation;Cells;checkpoint therapy;Chronic;Clinical;clinical care;clinically relevant;Communication;cytokine;Cytotoxic T-Lymphocytes;Data;digital;Disease;effector T cell;Enzymes;exhaustion;experience;Experimental Designs;experimental study;Flow Cytometry;Fracture;fracture risk;Functional disorder;Future;Grant;Histology;Homeostasis;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immunoglobulin G;Immunology;immunoregulation;Immunotherapy;Impairment;Infiltration;Inflammation;Inflammatory;Interferons;Knock-out;Ligands;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Metastatic Neoplasm to the Bone;microCT;Modeling;Molecular;Mus;Musculoskeletal;Myelogenous;Myeloid-derived suppressor cells;nano-string;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Osteoclasts;Osteogenesis;Pathological fracture;Patient-Focused Outcomes;Patients;pharmacologic;Phase;Phenotype;Population;Postdoctoral Fellow;prevent;Prevention;programmed cell death protein 1;receptor;Regulatory T-Lymphocyte;Reporting;Research;Research Personnel;Research Project Grants;Resistance;Resources;Role;Sampling;Serum;Signal Pathway;single-cell RNA sequencing;skills;stem;success;T cell infiltration;T memory cell;T-Cell Depletion;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;TNFSF11 gene;Toxic effect;Training;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Universities;Writing;Zoledronic Acid

PROJECT_TITLE: PD-1 blockade effects on bone strength and metastatic progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Colorectal Cancer;Comparative Effectiveness Research;Data Science;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE: This F99/K00 proposal focuses on engineering innovative computational tools that integrate multiscale multimodal cancer patient data for the development of prognostic and predictive markers of clinical outcomes. Comprehensive deep learning frameworks combining genomics, pathology, radiology, and clinical patient data can capture intricate cross-scale associations, enabling identification of reliable markers for determining a treatment’s likelihood of success. Such markers could facilitate the selection of optimal treatment regimes, leading to improved long-term outcomes and a transformative impact on cancer management.

PI_NAMEs: KREBS, OLIVIA  (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Adjuvant Therapy;Adopted;Aftercare;Age;Alternative Therapies;Architecture;Attention;Bioinformatics;Biological;Biological Process;biomarker driven;Breast;cancer biomarkers;Cancer Patient;cancer survival;Characteristics;chemoradiation;chemotherapy;Classification;Clinical;Clinical Data;clinical translation;Collaborations;Computer Analysis;computerized tools;convolutional neural network;Cytotoxic Chemotherapy;Data;Data Analyses;data integration;data modalities;deep learning;deep learning model;Demographic Factors;demographics;Development;digital pathology;Disease-Free Survival;Disparate;Disparity;DNA Sequence Alteration;Early treatment;Eligibility Determination;Engineering;Ensure;epigenomics;experience;Foundations;Future;Gene Expression;gene therapy;Genetic Variation;Genome;genome sequencing;Genomics;Glioblastoma;Glioma;Goals;health disparity populations;Histology;Image;Image Analysis;Immune;Immunotherapy;improved;In complete remission;innovation;Investigational Therapies;Knowledge;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Maps;Measurement;Medical Imaging;Mentors;Methodology;Modeling;Molecular;Monoclonal Antibodies;Morphology;multidisciplinary;Multimodal Imaging;multimodal modeling;multimodality;multiple omics;multiscale data;mutational status;Oncology;optimal treatments;Outcome;Pathology;pathology imaging;patient response;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Phase;Phenotype;post-doctoral training;Postdoctoral Fellow;Precision therapeutics;predict clinical outcome;predicting response;predictive marker;predictive tools;prognostic;Prognostic Marker;prognostic tool;Protocols documentation;Quality of life;Race;radiological imaging;Radiology Specialty;Rectal Cancer;Rectum;Recurrence;Regimen;Research;research clinical testing;Research Personnel;Research Project Grants;response;Risk;Risk Assessment;risk prediction;risk stratification;segregation;Series;sex;skills;Solid;Source;Stains;standard of care;Stratification;success;survival prediction;targeted agent;Therapeutic;Thinness;Time;Tissues;transcriptome sequencing;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Biology;Tumor Volume;Work

PROJECT_TITLE: Integrative Deep Learning Models for Multimodal Markers of Cancer Treatment Outcomes


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narratives Age-related macular degeneration (AMD) is a leading cause of blindness at ages > 50. The objective of this project is to establish a novel mouse model that integrates multiple environmental and genetic factors suspected to contribute to AMD in human patients. The availability of such a model may greatly enhance our knowledge of AMD pathology and facilitate the development of novel AMD therapies.

PI_NAMEs: FONG, GUO-HUA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Acceleration;Acute;ADAMTS9 gene;Age;Age Months;age related;Age related macular degeneration;Aging;aging process;Anatomy;angiogenesis;Animal Model;Area;Back;Basement membrane;bevacizumab;Blindness;Blood capillaries;Bruch's basal membrane structure;Candidate Disease Gene;cell motility;Cells;Cessation of life;Choroid;Choroidal Neovascularization;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;design;Deterioration;Development;Diet;Doxycycline;Edema;Environment;Environmental Risk Factor;Euthanasia;extracellular;Exudative age-related macular degeneration;Female;Frequencies;Gene Activation;Genes;Genetic;Genetic Predisposition to Disease;Hand;Homologous Gene;House mice;Human;Infiltration;interest;Invaded;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Lasers;Life;Light;Lipids;Lipofuscin;Macrophage;macula;male;Mediating;Messenger RNA;Modeling;Molecular;Monitor;monolayer;mouse model;Mus;Names;novel;novel therapeutic intervention;novel therapeutics;Open Reading Frames;overexpression;Pathologic;Pathology;Patients;Pattern;Peripheral;Phase;Phenotype;Photoreceptors;Phototherapy;Population;Proteins;Reporting;Research;Research Personnel;Research Project Grants;Retina;Risk;Role;Small Interfering RNA;Smoking;Structure of retinal pigment epithelium;Testing;therapy development;Thick;Tight Junctions;Time;Tissues;tool;Transgenes;Vision;Wild Type Mouse

PROJECT_TITLE: A Novel Mouse Model for Spontaneous and Age-Related Choroidal Neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Despite the unprecedented success of immune checkpoint blockade therapies that tremendously improved patient survival in certain types of cancer, such as melanoma and non-small cell lung cancer, it has been recognized that the response rate to current immunotherapies is still below 30% in most cancer types. In this proposal, we aim to (1) functionally and therapeutically interrogate tumoral secreted-protein-mediated T-cell exclusion from the tumor microenvironment to turn “cold” tumors “hot”, and (2) identify additional tumor microenvironment-specific molecules that impair the maintenance of T-cell quantity and effector functions in inflamed tumors to maximize the durability of anti-tumor immunity. Collectively, the proposed research will address the urgent need in therapeutic innovations for patients with primary and acquired resistance to current immunotherapies, and provide most patients personalized therapeutic strategies tailored to their pathological classifications.

PI_NAMEs: YANG, XUAN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Animal Model;anti-PD-1;anti-PD-1/PD-L1;Apoptosis;Apoptotic;bench to bedside;Binding;Biological Process;C57BL/6 Mouse;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;candidate identification;Categories;Cell surface;chemokine;Chemotaxis;Chemotaxis Inhibition;Chimeric Proteins;Classification;Clinical;comparative;CXCL11 gene;Development;domain mapping;effector T cell;Exclusion;exhaustion;extracellular;Failure;falls;Fellowship;Functional disorder;Goals;high throughput screening;Human;Immune;immune activation;immune checkpoint blockade;immune-related adverse events;Immunity;Immunocompetent;Immunologics;Immunotherapy;Impairment;improved;In Vitro;in vivo;Incidence;inducible gene expression;innovation;Investigation;Knock-out;Leucine-Rich Repeat;Maintenance;Malignant Neoplasms;Mediating;Melanoma;Memory;migration;Molecular;Monoclonal Antibodies;Movement;multiple omics;Mus;N-terminal;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;overexpression;pancreatic cancer model;Pathologic;patient subsets;Patients;personalized therapeutic;Phase;Phenotype;prevent;programmed cell death ligand 1;Proliferating;Protein Secretion;Proteins;receptor;Research;Resistance;response;secondary lymphoid organ;Signal Transduction;Stains;success;T cell infiltration;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-cell inflamed;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;Training;transmission process;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Tumor-Secreted Protein;Validation

PROJECT_TITLE: Discovery of Novel Therapeutic Strategies for Cancer Immunotherapy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

ORG_STATE: MA

PHR: OTHER PROJECT INFORMATION – Project Narrative The proposed research is relevant to public health because it addresses the intersection of two public health crises in the U.S., notably by assessing the extent to which the opioid crisis has contributed to elevated levels of intimate partner violence (IPV). Given the severe adverse consequences of IPV for the physical and mental health of victims and children, understanding whether supply-side policies implemented in response to the opioid crisis have had spillover effects on the risk of IPV perpetration and victimization is critical for evaluating the full societal costs and benefits of these policies, and for identifying sub-populations at heightened risk of IPV exposure. This project will evaluate for the first time the effects of policy-induced changes in opioid use on the risk of IPV perpetration/victimization, and in the process inform a key public health concern relevant to the NIH's mission at the intersection of the opioid epidemic and its impact on violence towards women.

PI_NAMEs: DAVE, DHAVAL M. (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: access restrictions;Address;Adoption;adverse outcome;Affect;Age;Aggressive behavior;Alcohols;Behavior;Characteristics;Child;Communities;Conflict (Psychology);cost;Costs and Benefits;Crime;Data;Data Set;Data Sources;design;Dimensions;Distal;economic cost;Economics;Education;Emotions;Employment;Epidemiology;Ethnic Origin;experience;Family;Female;Fentanyl;Formulation;Geographic Locations;Health Care Costs;Health Policy;Heroin;Heterogeneity;Homicide;illicit opioid;Individual;innovation;Intervention;intimate partner violence;Law Enforcement;Link;men;Mental Health;Methods;Mission;Monitor;nonmedical use;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid overdose;opioid policy;opioid use;opioid user;Oxycodone;Pathway interactions;Patient Self-Report;Patients;perpetrators;pharmacologic;physical conditioning;Play;Policies;prescription monitoring program;Prevalence;prevent;Process;productivity loss;Property;Public Health;Quasi-experiment;Race;Recreation;Reporting;Research;response;Risk;Risk Factors;Role;Sample Size;Severities;sex;Sexual Partners;sexual violence;Side;social;societal costs;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;success;Surveys;System;Time;treatment effect;treatment services;trend;United States;United States National Institutes of Health;Variant;Victimization;Violence;violence exposure;violence perpetration;violence victimization;Voice;Vulnerable Populations;Woman

PROJECT_TITLE: Spillover Effects of Policies Targeting Opioid Abuse on Intimate Partner Violence

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE Chronic subdural hematoma (CSDH) is one of the most common types of intracranial hemorrhage and has seen recent sharp increases in incidence in the aging population. Although the hematoma resolves in many patients, in others the brain does not reexapand to fill the space after treatment. In this project, we explore the measurement of brain mechanical properties, noninvasively with MRI, to predict patients who will demonstrate reexpansion of the brain after treatment for CSDH.

PI_NAMEs: SUTTON, BRADLEY P (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acute;Adult;Affect;Aftercare;Age;aging population;Animals;Anticoagulants;Architecture;Area;Bilateral;biomarker identification;Blood;Brain;brain based;Brain Mapping;brain tissue;Cephalic;cerebral atrophy;Characteristics;Chronic;Clinical;clinical biomarkers;clinical care;clinical research site;Clinical Trials;Complex;Contralateral;Craniotomy;Data Set;density;Development;Devices;Diagnosis;Disease;Drainage procedure;Elasticity;Evidence based treatment;Factor Analysis;Foundations;Future;General Population;Goals;Handedness;Headache;Health;Hematoma;Hemorrhage;high risk;human old age (65+);improved;Incidence;individualized medicine;inflammatory marker;Intervention;Intracranial Hemorrhages;Liquid substance;Literature;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Maps;Measurement;Measures;mechanical properties;Mechanics;Membrane;Meningeal Arteries;Meta-Analysis;Methods;Modality;Natural History;neurosurgery;non-invasive imaging;Odds Ratio;Older Population;Operative Surgical Procedures;Outcome Measure;outcome prediction;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;Procedures;Process;Prognostic Factor;Recovery;Recurrence;Repeat Surgery;Research;Resolution;Risk;risk prediction;risk stratification;Seizures;Severities;sex;Subdural Hematoma;Subdural space;Surface;Symptoms;Techniques;Therapeutic Embolization;Thick;timeline;Tissue Expansion;Tissues;tool;treatment strategy;Trephine hole;Veins;Work;X-Ray Computed Tomography

PROJECT_TITLE: Brain Stiffness as a Predictor of Chronic Subdural Hematoma Characteristics and Tissue Reexpansion

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Genetics;Radiation Oncology;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Parenterally administered, molecularly targeted radiotheranostics offers delivery of lethal doses of cytotoxic radiation to cancerous lesions and makes precision medicine possible in oncology. However, typical targeting vectors frequently suffer from poor therapeutic index, leading to severe underdosing of tumors. We propose a first-in-class, engineered, bacterial reporter gene-fusion approach for theranostic PET/beta-particle radiotherapy of solid tumors.

PI_NAMEs: CHEAL, SARAH MARIE (contact);FORBES, NEIL S.

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: 4T1;90Y;Acids;Address;Adult;Affinity;Antibodies;Apoptosis;Autoradiography;Bacteria;Beta Particle;Binding;Binding Proteins;Binding Sites;Biodistribution;Biological Assay;Biotinylation;Blood;Bone Marrow;Breast Carcinoma;cancer cell;cancer therapy;Cancerous;Cell Culture Techniques;Cell Death Induction;Cell Survival;Cellular Assay;chelation;Child;Chimeric Proteins;Clinical;Clinical Trials;clinically relevant;Complex;cytotoxic radiation;cytotoxicity;delivery vehicle;design;Discipline of Nuclear Medicine;DNA Double Strand Break;Dose;Dose Limiting;dosimetry;Drug Delivery Systems;Drug Kinetics;effective therapy;Engineering;Excretory function;experience;Flow Cytometry;Foundations;Gene Fusion;Genetic Engineering;Half-Life;Haptens;Harvest;Hour;Human;Image;image guided;Immunocompromised Host;Immunotherapy;In Vitro;in vivo;Infiltration;Injections;innovation;Intravenous;intravenous administration;Kidney;Large Intestine Carcinoma;Lead;Lesion;Lipoproteins;Liver;Malignant Neoplasms;Maximum Tolerated Dose;Membrane;Modality;Modeling;Molecular Target;Molecular Weight;Monitor;Mus;Necrosis;Normal tissue morphology;Oncology;Organ;Outcome;parenteral administration;Patient Selection;Patients;Penetration;Peptides;Performance;Plasma;Positron-Emission Tomography;precision medicine;preclinical study;Process;Property;Radiation;Radiation therapy;Radiation Tolerance;Radio;Radioactivity;Radioimmunotherapy;Radioisotopes;Radiolabeled;Radionuclide therapy;Radiopharmaceuticals;receptor;Renal clearance function;Reporter;Reporter Genes;response;Risk;Route;Salmonella;serial imaging;Site;small molecule;Solid Neoplasm;spatiotemporal;Specificity;Spleen;subcutaneous;Surface;System;theranostics;Therapeutic;Therapeutic Index;Time;time interval;Tissues;Toxic effect;tumor;tumor specificity;Tumor Tissue;Tumor Volume;uptake;vector;Yttrium;Zirconium

PROJECT_TITLE: An engineered bacterial reporter gene fusion for radiotheranostics

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Epilepsy afflicts 1% of the population and is characterized by spontaneous seizures. About 30% of patients do not respond to current therapies. Thus a deeper understanding of the mechanisms that drive the disease are required. We have constructed a machine learning algorithm that can predict when a rat brain is about to enter a zone of high seizure risk. By analyzing rat brains as they transition from epochs of low seizure risk to high risk, we will uncover the molecular, cellular and network changes that push brains to the edge of a seizure. We will perform single cell sequencing and cellular recordings from brains that are in low and high seizure risk states.

PI_NAMEs: BERNARD, CHRISTOPHE ;ROOPRA, AVTAR S (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Alzheimer's Disease;Animals;Anticonvulsants;Biochemical;bioinformatics tool;Biological;Brain;Brain region;Canis familiaris;cell type;Cells;Chromosome Mapping;circadian;Data;differential expression;Disease;Drug resistance;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;experimental study;extracellular;Future;gene regulatory network;Genes;Goals;Harvest;high risk;Hippocampus;Image;Incidence;Individual;insight;Interneurons;Knowledge;Learning;Machine Learning;machine learning algorithm;Maps;Marketing;Modeling;Molecular;Nervous System Disorder;novel;Nuclear;Outcome;Patients;Pattern;Periodicals;Periodicity;Persons;Population;Portraits;post stroke;prevent;Property;Proteins;Proteome;Publishing;Pyramidal Cells;Rattus;Research;Resolution;Risk;Seizures;single cell sequencing;single-cell RNA sequencing;Surveys;Testing;Time;Tissues;tool;transcriptome

PROJECT_TITLE: Molecular determinants of high seizure risk times

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Narrative: Toxoplasma gondii causes severe opportunistic infection, mostly in unborn children and HIV/AIDS patients. The parasite employs an unique cell-division machinery that supports a fast and cell-lytic proliferation, which is responsible for tissue lesions followed by inflammation in e.g. the eye (Ocular Toxoplasmosis), the brain (causing Encephalitis) or the heart (causing myocarditis). Our research focuses on the parasite’s specialist cytoskeleton and seeks to better understand how parasite offspring is assembled, hereby highlighting potential new avenues for drug discovery in the future.

PI_NAMEs: ENGELBERG, KLEMENS  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TITLE: Assembly of the Toxoplasma cortical cytoskeleton

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This project will benefit public health by supporting improved diagnosis and more rapid recognition of dementia due to Alzheimer’s disease and related disorders in primary care settings.

PI_NAMEs: ROSEN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;accurate diagnosis;Achievement;Address;Age;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid;Attitude;Behavior assessment;Behavioral;Biological Markers;Biology;Blood;brain based;California;Clinical;Clinical assessments;Cognitive;cognitive testing;Collaborations;Communities;Data;Dementia;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Disclosure;Disease;Education;Eligibility Determination;Ethnic Origin;Etiology;Evaluation;experience;Expert Opinion;Face;Family;FDA approved;Focus Groups;Future;Goals;Gold;Guidelines;Image;Impaired cognition;improved;Interview;Laboratories;Language;medically underserved;mild cognitive impairment;Modeling;Neurodegenerative Disorders;Neurology;Outcome;Participant;Patients;Persons;Pilot Projects;Population;prevent;Primary Care;primary care practice;primary care provider;primary care setting;Provider;provider factors;Psychiatry;Public Health;Questionnaires;Recording of previous events;recruit;response;Sensitivity and Specificity;Socioeconomic Factors;Specialist;Stress;Surveys;symposium;Symptoms;Syndrome;therapy design;Time;underserved community;Visit;willingness;Work

PROJECT_TITLE: Advancing Diagnosis of Dementia in Primary Care Practice(ADDPCP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HONOLULU

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Proposal Narrative  The proposed study is to establish an in vitro model of the human yolk sac, which is a vital extra- embryonic organ to support embryo development during early pregnancy. The goal is to use such an in vitro model, or yolk sac organoid, to identify environmental factors that harm embryo development. Effective and swift identification of reproductively harmful factors is crucial to ensure healthy pregnancies.

PI_NAMEs: MARIKAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adopted;Affect;Animals;Blood Cells;Blood Vessels;Cell Aggregation;Cells;Cessation of life;Chemical Agents;Cyst;developmental toxicity;diabetic;diabetic embryopathy;Disease;early pregnancy;Embryo;Embryonic Development;Ensure;Environmental Risk Factor;experimental study;Exposure to;First Pregnancy Trimester;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Glucose;Goals;health assessment;healthy pregnancy;Hematopoiesis;Human;human pluripotent stem cell;Impairment;In Vitro;in vitro Model;Incidence;Infection;innovation;insight;Investigation;Knowledge;Link;Lipoproteins;loss of function;Modeling;Molecular;Morphology;Mus;novel;Nutrient;nutrient absorption;Organ;Organoids;Placenta;Play;Predisposition;Pregnancy;Pregnancy Maintenance;Procedures;Property;Proteins;Protocols documentation;Regulator Genes;Reporting;reproductive;Rodent;Role;Shapes;Site;Spontaneous abortion;stem cell model;stem cells;Structure;Testing;Tissues;Transcript;transcriptome;Transport Process;ultrasound;Up-Regulation;vasculogenesis;Yolk Sac

PROJECT_TITLE: Establishment of yolk sac organoids for developmental toxicity assessment

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Center for Disease Control data indicate that ~20% of adolescents and young adult women are prescribed oral contraceptives (OCs), yet our understanding of how synthetic hormones contained in OCs may impact the neurobiological landscape is markedly limited. We propose to measure neuron-derived exosome microRNA expression profiles in adolescent/young adult females (ages 15-22) prescribed oral contraceptives (OC) compared to natural cycling, OC naïve adolescent females. Study outcomes will elucidate the influence of exogenous hormones on brain development.

PI_NAMEs: ROBERSON-NAY, ROXANN  (contact);YORK, TIMOTHY P

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Active Biological Transport;Adolescent;Adolescent and Young Adult;Adult women;Affect;Age;Age Years;Alzheimer's Disease;Binding;Bioinformatics;Biological;Biology;blood-brain barrier crossing;Brain;brain based;brain shape;Cell surface;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Contraceptive Usage;Cross-Sectional Studies;Data;Data Collection;Development;differential expression;Dose;Down-Regulation;effective therapy;Equipment and supply inventories;Estrogen Analogues;Estrogens;exosome;experience;Exposure to;falls;Feedback;Female;Female Adolescents;Functional disorder;Future;Gene Chips;Gene Expression Regulation;Genomics;Goals;Gonadal Steroid Hormones;Gonadotropins;Health;Homeostasis;Hormonal;Hormonal Change;Hormones;Human;Human body;hypothalamic pituitary gonadal axis;imaging study;in vivo;indexing;innovation;insight;Laboratories;Life;Longitudinal Studies;Luteal Phase;Malignant Neoplasms;Measures;Membrane;Menarche;Menstrual cycle;Methods;MicroRNAs;Modeling;Network-based;neural;Neurobiology;Neurodegenerative Disorders;Neuronal Differentiation;neuronal patterning;Neurons;neurophysiology;Oral Contraceptives;Outcome Study;Ovarian Steroid Hormone;Ovulation;Pathway interactions;Pattern;Periodicals;Persons;Phase;Physiology;pill;Placebos;Progesterone;Progestins;Protocols documentation;recruit;Regulation;reproductive;Research;Signal Transduction;Structure;Time;Tissues;United States;Variant;Visit;Woman;Women's Health;xenoestrogen;young adult;young woman

PROJECT_TITLE: The Impact of Oral Contraceptives on Neuron-derived Exosomal miRNA Expression in the Developing Brain

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Current therapies for the major human demyelinating disease multiple sclerosis (MS) target its inflammatory component, and they are effective in modifying the disease course and in managing symptoms; however, they are not curative. Stimulation of central nervous system (CNS) resident myelinating cells, namely oligodendrocytes (OLGs), is seen as an important step toward a curative treatment. As an attempt toward the characterization of novel molecular mechanisms with the potential to modulate myelin repair, the present application seeks to explore a novel role of the glutamate transporter GLT-1 (EAAC2/SLC1A2) in promoting CNS remyelination via glutamate influx mediated intracellular responses in maturing OLGs.

PI_NAMEs: FUSS, BABETTE  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Affect;Astrocytes;Attenuated;Axon;Brain;Caliber;Carrier Proteins;Cell membrane;Cells;Central Nervous System;Characteristics;Chronic;Clinical;clinical practice;conditional knockout;Corpus Callosum;Cuprizone;curative treatments;Data;Demyelinating Diseases;Demyelinations;design;disability;Disease;Disease Progression;Down-Regulation;druggable target;Endosomes;Event;Excitatory Amino Acid Transporter 1;Excitatory Amino Acid Transporter 2;Family;Gene Transfer;Glutamate Transporter;Glutamates;Homeostasis;Human;Impairment;In Vitro;in vivo;in vivo regeneration;Inflammatory;insight;Knock-in;late endosome;Light;Lysosomes;Mediating;member;Membrane;Modeling;Molecular;Monomeric GTP-Binding Proteins;Multiple Sclerosis;multiple sclerosis treatment;Mus;mutant;Myelin;Myelin Proteins;myelination;Natural regeneration;Nervous System Disorder;novel;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pathologic Processes;Pathway interactions;Plasma;prenylation;Progressive Disease;protein transport;Proteins;Publishing;regenerative therapy;regenerative treatment;Regulation;Relapse;remyelination;repaired;response;restoration;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Sodium;solute;stem cells;symptom management;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;trafficking;Viral;young adult

PROJECT_TITLE: GLT-1/EAAT2 signaling as a novel player in myelin repair

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PHR: Bedaquiline is revolutionizing rifampin-resistant tuberculosis treatment. Our overall goal is to improve patient outcomes by providing critical information regarding the cause of bedaquiline resistance in M. tuberculosis, allowing for the development of tests to rapidly inform treatment decisions. Project Narrative

PI_NAMEs: METCALFE, JOHN ZAPATA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Affect;Alleles;Amino Acids;Antibiotics;Antimicrobial Resistance;Area;Bacteria;Base Pairing;Biohazardous Substance;Biological Assay;Catalogs;Clinical;clinical implementation;Complement;Data;Development;Diagnostic;DNA Binding Domain;drug repurposing;Drug resistance;Drug resistance in tuberculosis;efflux pump;Evolution;experimental study;Funding;Genes;Genetic Polymorphism;genetic variant;Genotype;Goals;improved;In Vitro;in vivo;Individual;insertion/deletion mutation;Libraries;Ligand Binding Domain;Methods;Minimum Inhibitory Concentration measurement;Minor;Modeling;Modernization;Molecular;molecular diagnostics;mortality;mouse model;Mus;mutant;Mutation;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;New Agents;Nucleotides;Oral;Outcome;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Phenotype;Plasmids;Positioning Attribute;Predisposition;preservation;pressure;Proteins;Regimen;Reporting;Research Activity;Resistance;resistance mutation;Resources;Rifampicin resistance;sample collection;scale up;screening;Silicon Dioxide;Single Nucleotide Polymorphism;Specimen;success;Techniques;Testing;Time;Treatment outcome;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Comprehensive characterization of Rv0678 bedaquiline resistance-conferring polymorphisms

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PROJECT NARRATIVE Mutations in GRIN2B, which encodes the GluN2B subunit of NMDA receptors, confer risk of ASD, but the underlying mechanisms remain unclear. We found that increased or decreased expression of the neuronal glutamate transporter, which modulates NMDA-GluN2B function, reciprocally impacts dopaminergic neuron function – a key neurotransmitter system associated with ASD – and downstream behavior. Here, we propose to determine the impact of diminished NMDA-GluN2B expression in dopaminergic neurons on dopaminergic neuron firing, release, and resulting behavior, with the goal of elucidating impact of Grin2b in dopaminergic circuits, and potentially informing precision-medicine interventions with NMDA-GluN2B compounds.

PI_NAMEs: CHOHAN, MUHAMMAD O;VEENSTRA-VANDERWEELE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Ablation;Acute;Affect;Agitation;Amphetamines;Animal Model;Animals;antagonist;Association Learning;Attenuated;autism spectrum disorder;awake;Behavior;Behavioral;Biological;Biological Assay;Cell model;Clinical Data;Compensation;Complex;conditional knockout;Corpus striatum structure;Data;de novo mutation;Desire for food;Development;developmental disease;Disease;disorder risk;Dopamine;Dopamine Agonists;dopamine system;dopaminergic neuron;Dorsal;Encephalopathies;Epilepsy;excitatory amino acid transporter 3;extracellular;FDA approved;Fiber;Functional disorder;gain of function;gene product;Genes;Genetic;genetic manipulation;Glutamate Transporter;Glutamates;Goals;habit learning;Heterozygote;Human;Hyperactivity;Impaired cognition;Impulsive Behavior;Impulsivity;in vivo;inattention;Individual;individuals with autism spectrum disorder;Injections;innovation;Intervention;Investigation;knockout animal;Learning;loss of function;Loss of Heterozygosity;Medial;Methodology;model of autism spectrum disorder;Modeling;Monitor;Motor;mouse model;Mus;Mutation;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neuroimaging;Neurons;neuropsychiatry;Neurotransmitters;optogenetics;overexpression;Pattern;Pedunculopontine Tegmental Nucleus;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Photometry;Play;precision medicine;Prefrontal Cortex;Psychological reinforcement;Publishing;receptor;receptor function;Regulation;repetitive behavior;response;Rewards;Risk;risk variant;Role;Signal Transduction;Single Nucleotide Polymorphism;Subgroup;Synapses;System;Techniques;Testing;transmission process;Variant;Ventral Striatum;viral rescue;Wait Time;Work

PROJECT_TITLE: Impact of Grin2b/GluN2B disruption on dopaminergic function and related behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Brain Disorders;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Precision Medicine;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Current referrals to newer antidepressant therapies (e.g. transcranial-magnetic stimulation (TMS)) are targeted for patients with treatment resistant depression (TRD), but TRD can only be established through multiple first- line treatment failures for the individual patient. The current study proposes to identify patients prone to treatment resistance by documenting monotherapy treatment failure (TF) across multiple first-line treatments, with the ultimate goal of referring to alternative therapies earlier in the treatment course. The focus of the study is to determine if initial TF is a reasonable proxy for subsequent treatment failure and thus treatment resistance in both the clinical trial and observational settings.

PI_NAMEs: KELLEY, MARY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Alternative Therapies;alternative treatment;anti-depressive agents;Attenuated;Biological Markers;Classification;Clinical;Clinical Trials;Cognitive Therapy;Combined Modality Therapy;Controlled Clinical Trials;cost;Data;Data Set;Development;Disease remission;Early treatment;Electronic Health Record;Failure;Future;Genetic Markers;Goals;Grant;Heterogeneity;High Prevalence;Incidence;Individual;individual patient;inhibitor;International;Intervention;Ketamine;Link;Major Depressive Disorder;Measures;Mental Depression;Methods;Modeling;Monitor;multimodal modeling;multimodality;Norepinephrine;Observational Study;partial response;patient stratification;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Positron-Emission Tomography;predicting response;Prediction of Response to Therapy;predictive modeling;Process;Provider;Proxy;Psychotherapy;Recommendation;Resistance;response;reuptake;Sampling;Selective Serotonin Reuptake Inhibitor;Serotonin;standard care;Subgroup;success;Testing;therapy resistant;Transcranial magnetic stimulation;treatment as usual;treatment choice;treatment duration;Treatment Failure;treatment group;treatment optimization;treatment response;treatment-resistant depression;Uncertainty;vagus nerve stimulation;Validation

PROJECT_TITLE: Identifying first-line treatment failure for earlier referral to alternative treatments in depression

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Schizophrenia is the 8th leading cause of disability world-wide and is associated with impaired decision-making related to difficulty processing information about choices that lead to potentially rewarding outcomes relative to potentially detrimental outcomes. The project leverages neuroimaging, eye-tracking, and daily experience monitoring to identify how attentional biases and the application of cognitive strategies impact decisions, and how activity in coordinated brain regions during evidence integration relate to real-world decision-making problems in people with schizophrenia. The results will guide interventions to empower those with schizophrenia to improve their decision-making capacity.

PI_NAMEs: ZALD, DAVID HAROLD (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Anhedonia;Anterior;Attention;attentional bias;Behavior;behavior prediction;Behavioral;behavioral impairment;Belief;Biological;Brain;Brain region;burden of illness;Choice Behavior;Chronic;cingulate cortex;Clinical;Cognition;Cognitive;cognitive process;cognitive reappraisal;comparison control;Data;Decision Making;decision-making capacity;disability;Educational process of instructing;empowerment;Environment;Etiology;Exhibits;experience;Failure;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;Goals;high reward;Impaired cognition;Impairment;improved;Individual;information processing;Insula of Reil;Intervention;intervention program;Life;medication nonadherence;Methods;Monitor;Motivation;neural;neural circuit;neuroimaging;neuroregulation;neurotransmission;novel;Nucleus Accumbens;Outcome;Paranoia;Participant;Persons;Phase;Process;programs;Psychoses;Research;Resources;reward processing;Rewards;Risk;Risk Behaviors;risk perception;Risk Taking;Role;Sampling;Sampling Studies;Schizophrenia;Severities;Signal Transduction;Source;Specificity;Stimulus;substance use;symptomatology;Symptoms;Testing;Uncertainty;Up-Regulation;Update;Visual;Visual attention;visual tracking;willingness;Work

PROJECT_TITLE: R21: Promoting Adaptive Decision-Making in Schizophrenia Through Improved Evidence Integration: A Combined Neuroimaging and Experience Sampling Study

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Recently, malaria incidence has considerably reduced because of the significant efforts in malaria control and elimination and many lives have been saved. But independent emergence of drug resistance and most importantly to the frontline treatment regimen, artemisinin combination therapy has threatened this progress. We propose that K13 independent artemisinin resistance is emerging in Bangladesh; that K13 independent resistance will serve as a catalyst for highly resistant and fit K13 mutations to arise and spread in this population. We will use genomics, phenotyping, reverse genetics to identify these early genetic determinants and evaluate the propensity of K13 mutations to emerge and circulate in this population, to offer improved tools to inform malaria treatment and control spread of drug resistance.

PI_NAMEs: MUKHERJEE, ANGANA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Africa;Aftercare;Anti-malarial drug resistance;Anti-malarials;Artemisinins;Bangladesh;Bangladeshi;Biological Assay;Candidate Disease Gene;candidate validation;catalyst;causal variant;Characteristics;Chromosome 13;Clinical;Clinical assessments;Code;cohort;Combined Modality Therapy;Complex;Containment;cost;Cost Analysis;Country;CRISPR/Cas technology;drug action;Drug resistance;drug sensitivity;Early Diagnosis;Early identification;Eastern Africa;Effectiveness;Engineering;Ensure;Evaluation;Face;Falciparum Malaria;fitness;forest;Genes;Genetic;genetic approach;Genetic Determinism;genome editing;genome sequencing;genome-wide;Genomics;Genotype;Growth;improved;In Vitro;in vitro Assay;Incidence;India;Infection;Location;Malaria;malaria infection;Mediating;Modeling;Molecular;mutant;Mutation;Myanmar;Parasite resistance;Parasites;Parents;Patients;Pharmaceutical Preparations;Phase;Phenotype;Plasmodium falciparum;Population;Positioning Attribute;Predisposition;Reporting;Resistance;resistance gene;resistance mutation;Resolution;reverse genetics;Sequence Analysis;southeast Asian;spatiotemporal;Tertiary Protein Structure;Testing;Time;tool;trait;Treatment Protocols;Validation;whole genome

PROJECT_TITLE: Deciphering P. falciparum artemisinin resistance in Bangladesh: a genotypic-phenotypic evaluation of Kelch13 dependent and independent determinants


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

PHR: Narrative The aging global population is facing an increased risk of cognitive decline, often characterized by familiarity bias and memory interference. Our research focuses on identifying the neural circuits behind memory interference to understand these deficits. We aim to explore how age- related deterioration in the dopaminergic innervation of the lateral entorhinal cortex contributes to memory interference.

PI_NAMEs: PASSOS MINGOTE, SUSANA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;age effect;age related;age related changes;age related deterioration;Age-associated memory impairment;Aging;aging related;Association Learning;Automobile Driving;brain dysfunction;cognitive ability;cognitive enhancement;Complex;conditioned fear;Cues;Detection;Deterioration;dopaminergic neuron;entorhinal cortex;Environment;Event;Exhibits;experimental study;Exposure to;Familiarity;Fiber;Foundations;Functional disorder;Generations;Goals;human old age (65+);Image;Impaired cognition;in vivo;information processing;Label;Lateral;Learning;Life;Link;Measures;Memory;Mus;nerve supply;neural;neural circuit;Neurocognitive;Neurons;neurotransmission;novel;novelty processing;old mice;older adult;Older Population;optogenetics;Phase;Photometry;Population;Research;response;Retrieval;Risk;Role;sensor;Shock;Signal Transduction;Stimulus;System;Testing;Update;Virus

PROJECT_TITLE: Dopaminergic Mechanism for Familiarity and Memory Interference

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health

ORG_CITY: CLEMSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Clinicians in emergency departments experience persistent burnout and psychological distress. This research would help to understand how factors (in the department, the pandemic, and personal characteristics) contribute to their experience and provide a visualization tool to communicate current status to hospital leadership. This work would support decisions to improve clinician well-being and corresponding improvements in patient care.

PI_NAMEs: TUCKER, EMILY  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Absenteeism;Accident and Emergency department;Acute;Address;adverse outcome;Affect;burnout;Categories;Cessation of life;Characteristics;Clinical;Communication;contextual factors;cost;COVID-19;COVID-19 incidence;COVID-19 pandemic;Crowding;Data;Data Aggregation;Data Analyses;data repository;Demographic Factors;Development;Effectiveness;Emergency Situation;Employee;empowerment;Ensure;evidence base;experience;Factor Analysis;Feedback;Future;future implementation;Goals;Health;Health system;Hospitals;Human;Human Resources;improved;indexing;Individual;insight;Institution;Interruption;Interview;Leadership;Link;Location;Machine Learning;machine learning method;machine learning model;Measures;Methods;Modeling;Modification;Nature;Outcome;pandemic disease;Patient Care;Patients;Performance;Personal Satisfaction;Policies;Positioning Attribute;Predictive Factor;predictive modeling;Predictive Value;prisma;Process;professional atmosphere;psychological distress;Radar;Reporting;Research;Risk;Risk Factors;rural setting;Site;South Carolina;Speed;statistical and machine learning;Statistical Models;stressor;Structure;support tools;Surveys;System;Time;two-dimensional;Uncertainty;usability;Validation;Visual;visual tracking;Visualization;Visualization software;Work

PROJECT_TITLE: Understanding and Visualizing Emergency Department Clinician Well-Being and Strain

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

PHR: PROJECT NARRATIVE Burnout among clinicians is a significant concern in Emergency Departments across the US and globally, and with increasing workload, additional shift work requirements, staffing shortages, and other stress-inducing activities, clinician well-being can be significantly compromised. This has ramifications on patient flow and quality of care, including increased handoffs, increased miscommunications, and reduced time for patient/clinician interaction. The purpose of this proposal is to create a framework for redesigning ED nurse and physician shift schedules, integrating clinician preferences and physiological parameters to improve clinician well-being and patient outcomes.

PI_NAMEs: TAAFFE, KEVIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Redesigning Emergency Department Clinician Shift Scheduling to Improve Well-being and Patient Outcomes (EDSHIFT)

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]