NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease and affects some genetic ancestries more than others, yet the definitive genetic sources of these clinically-relevant differences are unknown. This proposed work employs an in vitro functional genomics pipeline to comprehensively identify causative ancestry- specific noncoding variants that putatively underlie this differential penetrance. This work will greatly enrich our understanding of genetic predisposition to sporadic Alzheimer’s disease, enabling early identification of the individuals most at risk, stratification of patients into disease-relevant subgroups, and tailored therapeutic intervention.

PI_NAMEs: GARDELL, ZACHARY A (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Affect;African;age related;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-4;Asian ancestry;Astrocytes;ATAC-seq;Automobile Driving;Binding;Binding Sites;Bioinformatics;Biological Assay;Biology;Brain;brain cell;causal variant;Cell Line;Cell model;cell type;Cells;clinically relevant;Communication;Dementia;Disease;disease phenotype;Early identification;East Asian;Environment;Epigenetic Process;epigenomic profiling;European;European ancestry;Exhibits;experimental study;Female;Fostering;functional genomics;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;genetic risk factor;Genetic Transcription;genetic variant;genome editing;genomic locus;Goals;Heritability;Homozygote;Human;improved;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Knowledge;Leadership;Link;male;Maps;meetings;Microglia;Modeling;molecular phenotype;Nervous System Disorder;Neurons;Pathologic;patient population;patient stratification;Penetrance;Population;Population Heterogeneity;Predisposition;prognostication;Protein Isoforms;Regulation;Regulatory Element;Reporter;Research;resilience;Resources;Risk;risk variant;Role;Sampling;Science;Source;Structure;Subgroup;Testing;Therapeutic Intervention;therapeutic target;Training;transcription factor;transcriptome sequencing;transcriptomic profiling;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Determining the genetic drivers of ancestry-specific differential penetrance of APOE4 in sporadic Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Microbiome;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE In sub-Saharan Africa, malaria and growth failure continue to threaten child health and survival. Intermittent preventative treatment in pregnancy (IPTp) and childhood (IPTc) are promising strategies for malaria control that may also improve growth outcomes through the prevention of mediating factors such as low birthweight, systemic inflammation, and gut microbiome dysbiosis. In this proposed study, we will use causal inference methods to estimate the direct and indirect effects of IPTp and IPTc on child growth.

PI_NAMEs: NGUYEN, ANNA THUY NHU (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 1 year old;2 year old;Address;Affect;Africa South of the Sahara;Age;Anti-malarials;Award;Biological;Biological Markers;Birth;Birth Weight;Blood specimen;career;career development;Chemoprevention;Child;Child Development;Child Health;Childhood;Communicable Diseases;Data;Data Analyses;design;Development;Dietary Intervention;doctoral student;dysbiosis;early childhood;early onset;effective intervention;Effectiveness;Epidemiology;Equation;Failure;Fellowship;Foundations;Future;future implementation;Geography;global health;Goals;Growth;gut microbiome;Height;high risk;improved;Incidence;Individual;infancy;Infant;Infection;Infectious Disease Epidemiology;Inflammation;Inflammatory;Influentials;Intervention;Intervention Trial;Lead;Life;low and middle-income countries;Low Birth Weight Infant;Malaria;malaria infection;malaria transmission;Measurement;Measures;Mediating;Mediation;Mediator;medical schools;Mentorship;Methodology;Methods;microbiome;microbiome analysis;microbiome composition;Morbidity - disease rate;mortality;Mothers;Neonatal;Outcome;Pathway interactions;Placebos;Population;population health;Positioning Attribute;postnatal period;Pregnancy;Pregnant Women;prenatal;Prevalence;prevent;Prevention;Preventive treatment;programs;Randomized;randomized trial;Regimen;Research;Research Personnel;Risk;Risk Factors;Sampling;Series;skills;stool sample;Sulfadoxine;systemic inflammatory response;targeted delivery;Training;transmission process;Uganda;wasting;Weight;Work

PROJECT_TITLE: Evaluating the causal effects of anti-malarial chemoprevention in pregnancy and childhood on growth outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PHR: Project Narrative Typhoid fever is among the most common invasive bacterial illnesses worldwide, and new conjugate vaccines have demonstrated a high degree of effectiveness in preventing this disease. There is a need for improved tools to understand where typhoid fever burden is greatest, to prioritize vaccine introductions and monitor their impact. This project leverages a cluster-randomized typhoid conjugate vaccine trial to investigate three novel tools—serological, wastewater surveillance, and phylodynamic—to characterize typhoid transmission intensity and evaluate vaccine impact, with a goal of identifying scalable strategies to monitor typhoid burden worldwide.

PI_NAMEs: ANDREWS, JASON RANDOLPH (contact);CHARLES, RICHELLE C;JOHN, JACOB

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Address;Adoption;Adult;Antigens;Antimicrobial Resistance;arm;Bacteriophages;Biological Assay;Blood;burden of illness;Cessation of life;Child;Clinical;Cluster randomized trial;Collection;Communities;community burden;Conjugate Vaccines;cost;Country;Data;density;Detection;Development;Diagnosis;diagnosis standard;Diagnostic;Disease;Dryness;Effectiveness;Enrollment;epidemiological model;Genetic;genome sequencing;Genomics;Goals;Haplotypes;Health system;Human;Immunoglobulin G;improved;Incidence;Income;India;Individual;Infection;Infrastructure;innovation;International;Intestines;Knowledge;Laboratories;low and middle-income countries;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;novel;novel strategies;Participant;Pattern;Phase;Population;population based;Population Sizes;prevent;programs;prospective;Public Health;Randomized;randomized trial;Recommendation;Reference Standards;resistant strain;Resource-limited setting;Resources;response;Risk;Salmonella enterica;Salmonella typhi;Sanitation;serological marker;Serology;serosurvey;Serotyping;Source;Spottings;Surveillance Methods;Testing;Time;tool;Translating;transmission process;Typhoid Fever;Typhoid Vaccine;Vaccinated;Vaccination;vaccine evaluation;vaccine trial;Vaccines;wastewater surveillance;Water;whole genome

PROJECT_TITLE: Novel tools for measuring typhoid vaccine impact

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs. single bouts of sustained exercise on metabolic, cognitive, and affective responses in overweight and obese children at risk for type 2 diabetes. The use of continuous glucose monitoring will provide insight into the daily and cumulative metabolic effects of each condition that have thus far not been studied. In- lab studies demonstrating sustained efficacy of this approach in ameliorating negative effects of sedentary behaviors in children are necessary for the optimization of field-based interventions. Given the lack of success of interventions to prevent obesity-related diseases and increasing rates of type 2 diabetes in children and its related healthcare costs, our proposal addresses a critical public health need by testing of novel intervention strategies to reduce obesity-related diseases in overweight and obese children.

PI_NAMEs: BELCHER, BRITNI RYAN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: 11 year old;Acute;Address;Adolescence;Adult;Affect;Affective;Age;Alternative Therapies;Anxiety;anxiety states;Area Under Curve;Attention;Behavior;blood glucose regulation;C-Peptide;Cause of Death;Child;Childhood;Cognition;Cognitive;Cognitive deficits;cognitive function;comparative efficacy;Continuous Glucose Monitor;Data;depressive symptoms;design;Dietary intake;Disease;effectiveness evaluation;efficacy testing;Emotional;energy balance;Episodic memory;euglycemia;Exercise;experimental study;Glucose;glucose monitor;glucose tolerance;Goals;Guidelines;Health Care Costs;healthy weight;Hour;Hyperglycemia;improved;Incidence;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Interruption;Intervention;life span;Measures;Mental Depression;Mentored Research Scientist Development Award;Metabolic;Metabolic Diseases;Moderate Exercise;Monitor;Mood Disorders;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;negative mood;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Obesity associated disease;obesity in children;obesity prevention;obesity risk;OGTT;Outcome;Overweight;Participant;Phase;Physical activity;Predisposition;Prevention;Prevention strategy;psychologic;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;response;Risk;Risk Factors;sedentary;sedentary lifestyle;Short-Term Memory;success;Testing;Time;Translating;type 2 diabetes in children;United States National Institutes of Health;Walking;Weight;Work;Youth

PROJECT_TITLE: Testing the efficacy of multi-day interruptions in sedentary behaviors on metabolic, cognitive, and affective outcomes in youth at risk for Type 2 diabetes

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative  Latino Ancestry and other minority populations have been poorly represented in large-scale genomic studies, and yet these populations suffer the largest disparities in health care and outcomes and have the potential to broaden our knowledge of human genetics. The Latino Ancestry-Genomic Psychiatry Cohort (LA-GPC) will combine the Latino Ancestry (AA) participants in this study, the VA-CSP study, the Colombian study and the NeuroMex study creating a study population over 76,000 LA participants. This analysis has the potential for significant novel discovery.

PI_NAMEs: BIGDELI, TIM BERNARD;FANOUS, AYMAN H;PATO, CARLOS N (contact);PATO, MICHELE T

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Admixture;African ancestry;Americas;Amerindian;ancestry analysis;Benchmarking;Bipolar Disorder;Chromosome Mapping;Clinical;cognitive testing;cohort;Collaborations;Colombian;Complex;Data;Diagnosis;Disease;Enrollment;Equipment and supply inventories;European;European ancestry;Event;experience;Funding;Genetic;genetic association;Genetic Polymorphism;Genetic Recombination;Genetic Research;Genetic Risk;Genetic Variation;Genome;genome wide association study;genome-wide;genome-wide analysis;Genomics;Goals;Haplotypes;health care disparity;Heritability;Human Genetics;human migration;improved;Individual;Interview;Joints;Knowledge;Latino;Latino Population;Linkage Disequilibrium;Maps;Medical;Meta-Analysis;Mexican;Minority Groups;National Institute of Mental Health;neuropsychiatry;novel;Outcome;Participant;Patient Self-Report;Patients;Phase;polygenic risk score;Polygenic Traits;Population;Population Heterogeneity;psychiatric genomics;psychiatric symptom;Psychiatry;Psychoses;Publishing;Questionnaires;Resolution;risk variant;Sampling;Schizophrenia;screening;Signal Transduction;SNP genotyping;statistics;Structure;study population;synergism;Variant;whole genome

PROJECT_TITLE: Latino Ancestry Genomic Psychiatry Cohort

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Depression and anxiety in youth are serious public health concerns for which more targeted prevention efforts are needed. This study tests the efficacy of an app-based mindfulness intervention that specifically targets skills for regulating negative affect in order to prevent anxiety, depression, and associated impairment in at-risk adolescents.

PI_NAMEs: ADAM, EMMA K;CHAVIRA, DENISE A;CRASKE, MICHELLE G;GARBER, JUDY  (contact);ZINBARG, RICHARD E

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 16 year old;Adolescence;Adolescent;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Attention;attentional control;Child;Depressive disorder;depressive symptoms;Diagnostic;Dimensions;Disease;dosage;Dose;Ecological momentary assessment;effective intervention;efficacy testing;emerging adult;Emotional;Exercise;experience;follow-up;Functional disorder;Goals;Health Services Accessibility;Heritability;high risk;Impairment;Improve Access;improved;Intervention;intervention program;Link;Longitudinal Studies;Measures;Mediating;Mental Depression;mindfulness;mindfulness intervention;Mindfulness Training;mobile computing;Modeling;Moods;negative affect;Negative Valence;Online Systems;Onset of illness;Outcome;Participant;Phase;post intervention;prevent;Prevention;Prevention trial;Process;programs;prospective;Psychopathology;Public Health;Randomized;Research;Research Domain Criteria;response;Risk;Risk Factors;Sampling;selective prevention;skills;smartphone application;social;Symptoms;systems research;Technology;Testing;trait;Youth

PROJECT_TITLE: Targeting negative affect through mindfulness training in youth at risk for internalizing problems


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Narrative  Many bats can harbor viruses for prolonged periods of time without developing disease, but the immunological mechanisms that support such asymptomatic chronic infections are unknown. We have recently developed enteroid cultures as a novel in vitro model to study viral infection in the Jamaican fruit bat intestine, which is a key target organ for multiple viruses. In our study, we will infect enteroids derived from Jamaican fruit bat or human tissue with three different RNA viruses and investigate how viral infections impact epithelial antiviral responses and intestinal epithelial cell function.

PI_NAMEs: BIMCZOK, DIANE  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Adult;Anti-viral Response;antiviral immunity;Biological Response Modifiers;Cell Physiology;Cell Survival;Cells;Characteristics;Chiroptera;chronic infection;Complex;Coronavirus;cytotoxicity;Diarrhea;Diet;Disease;enteric pathogen;Enteritis;Epithelial Cells;Epithelium;experience;experimental study;Family Pteropodidae;Feces;Filovirus;Fruit;Functional disorder;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Gene Expression Profiling;genome annotation;Goals;Henipavirus;Human;human tissue;Immune system;Immunologics;Immunology;in vitro Model;Individual;Infection;Infectious Diseases Research;Influenza;influenzavirus;innate immune mechanisms;Innate Immune Response;innovation;innovative technologies;insight;Interferon Activation;Interferon alpha;Interferon-beta;Interferons;intestinal barrier;intestinal epithelium;Intestines;Jamaican;Kinetics;Maintenance;Mammals;Measures;Middle East Respiratory Syndrome Coronavirus;model organism;Modeling;novel;Organ;Organoids;Outcome;pathogen;Pathogen detection;pathogen spillover;pathogenic virus;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Pattern;Pattern recognition receptor;Predisposition;protective pathway;Proteome;Proteomics;Recombinant Interferon Alfa;Rectum;repair function;Resistance;response;RNA Viruses;Role;Signal Transduction;Simuliidae;Small Interfering RNA;Small Intestines;small molecule inhibitor;spillover event;Swab;Symptoms;System;Tacaribe virus;Testing;Time;tissue derived stem cell;Tissue-Specific Gene Expression;transcriptomics;Viral;Virus;Virus Diseases;Virus Replication;Work;Zika Virus;Zoonoses

PROJECT_TITLE: Mechanisms of antiviral immunity and tolerance in the intestinal epithelium of Jamaican Fruit Bats


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative DNA and RNA nucleobase modifications are relevant for fundamental biochemical and biophysical experiments and are widespread throughout biology. DNAzymes are catalytic DNA sequences, analogous to protein enzymes as catalytic amino acid sequences, that unlike protein enzymes can be identified from initially random DNA sequence populations by in vitro selection. The proposed Focused Technology Research and Development seeks new DNAzymes for in vitro site-specific acylation and alkylation of the nucleobase amino groups of cytosine, guanine, and adenine, which will enable a range of biochemical, biophysical, and biological experiments involving site-specifically modified DNA and RNA nucleotides.

PI_NAMEs: SILVERMAN, SCOTT K (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acylation;Address;Adenine;Aldehydes;Alkylation;Alkynes;Amination;Amines;Amino Acid Sequence;amino group;aqueous;Azides;Base Pairing;Binding;Biochemical;Biochemistry;Biological;Biology;Biophysics;Buffers;Catalysis;Catalytic DNA;Chemicals;Cytosine;Development;Directed Molecular Evolution;DNA;DNA Modification Process;DNA Sequence;Enzymes;Esters;experimental study;functional group;functional improvement;Goals;Guanine;Hemin;Hydrolysis;Imines;In Vitro;Incubated;Individual;innovation;Laboratories;Length;Messenger RNA;Modification;N acylation;Nature;new technology;novel strategies;Nucleic Acids;nucleobase;Nucleotides;Oligonucleotides;Peptides;peroxidation;Population;Positioning Attribute;pressure;Procedures;Proteins;Publications;Randomized;Reaction;Recording of previous events;Reporting;RNA;RNA Ligase (ATP);S phase;Salts;Series;Site;small molecule;Solid;Specificity;Technology;technology research and development;tool;Variant;Work

PROJECT_TITLE: DNAzymes for Site-Specific DNA and RNA Nucleobase Modification

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Dr. Cappola proposes to augment her scientific skills and program building, continue to develop the local environment for mentoring new clinical investigators who perform patient-oriented research in older people, and conduct studies that will impact the diagnosis and treatment of hypothyroidism in older individuals.

PI_NAMEs: CAPPOLA, ANNE R (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adult;Adverse effects;Age;age group;age related;age related changes;age stratification;aged;Aging;American;Award;biomedical informatics;Blood Tests;cardiovascular risk factor;Cardiovascular system;care costs;career development;Cementation;Cessation of life;Clinical;clinical investigation;Clinical Investigator;Clinical Sciences;cognitive testing;Collaborations;Communities;Confidence Intervals;Coronary heart disease;Data;Dedications;Dementia;Development;Diagnosis;Dose;Drug Prescriptions;Electronic Health Record;Electronic Publishing;Endocrine;Endocrinology;Environment;Faculty;Frequencies;Funding;Generations;Geriatrics;Goals;Health;Health Care Costs;Health system;Hip Fractures;human old age (65+);Hypothyroidism;Iatrogenesis;Impaired cognition;improved;Individual;individual patient;individual response;Institution;K-Series Research Career Programs;Leadership;Learning;Left;life span;medical schools;Medicare;Medicine;Mentors;Mentorship;Meta-Analysis;metabolic rate;Midcareer Investigator Award in Patient-Oriented Research;Monitor;mortality;normal aging;Older Population;Outcome;Outpatients;overtreatment;Participant;patient oriented;patient oriented research;Pattern;Pennsylvania;Persons;Pharmaceutical Preparations;Physical Function;Placebos;Population;Population Distributions;Prevalence;Prevention;Productivity;professor;programs;Publications;Reference Values;Research;Research Personnel;research study;Risk;Risk Reduction;Sample Size;skills;Specificity;Stroke;success;Symptoms;Testing;Therapeutic;Thyroid Gland;Thyroid Hormones;Thyrotoxicosis;Thyrotropin;Thyrotropin-Releasing Hormone;Thyroxine;Time;Training;Translational Research;Universities;Update

PROJECT_TITLE: Midcareer Investigator Award in Patient-Oriented Research in Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Estrogen;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE HIV infection, even when controlled with antiretroviral therapy, is a risk factor for cardiovascular disease (CVD), which occurs at younger ages in persons living with HIV than in the general population. Women living with HIV are at an even greater relative risk for CVD than men when compared to women and men of similar ages in the general population, possibly due to differences in estrogen levels and estrogen receptor function in women with and without HIV. The proposed research will explore the effects of HIV on estrogen receptor gene expression and translation in women, and will look the associations of estrogen receptor gene expression and translation with prevalent and progressive subclinical CVD in women living with and without HIV.

PI_NAMEs: MORAN, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Affect;Age;age difference;Aging;Antiinflammatory Effect;Antioxidants;antiretroviral therapy;arterial stiffness;Automobile Driving;Award;Binding;Biological Markers;Biology;Blood Vessels;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Carotid Arteries;carotid intima-media thickness;Cells;Centers of Research Excellence;Clinical;Clinical Research;cohort;Cohort Studies;Communicable Diseases;Data;Data Analyses;design;Disease;Disease Progression;early experience;endothelial dysfunction;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;experience;Fibrosis;Foundations;Gene Expression;General Population;Gonadal Steroid Hormones;high risk;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Immune;Immune system;Immune System Diseases;Inflammation;Inflammatory;innovation;Ischemic Stroke;Laboratories;Link;longitudinal analysis;Macrophage Activation;Master of Science;Measures;men;Menopausal Status;Menopause;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Myocardial Infarction;Myocardial Ischemia;Natural Immunity;normal aging;Organ;Participant;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Positioning Attribute;Premature Menopause;Premenopause;Prevalence;primary outcome;Process;prospective;protein expression;receptor;receptor expression;receptor function;recruit;Recruitment Activity;Relative Risks;Research;Research Personnel;Research Proposals;Research Training;Resources;Risk;Risk Factors;Role;Sampling;Scientist;secondary outcome;Serum;Sex Differences;skills;Specialized Center;Testing;Thick;Time;Training;training opportunity;translational scientist;Translations;trend;Vasodilation;Viral;Visit;Woman;women versus men;Women's Interagency HIV Study;Work;young woman

PROJECT_TITLE: Understanding the role of estrogen receptor expression in CVD risk in women with and without HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in these communities. We aim to address this gap by testing the effectiveness of a transdiagnostic secondary prevention program that can be embedded within home visiting services. Our study is grounded in participatory processes and led by a team of Indigenous and allied researchers.

PI_NAMEs: HAROZ, EMILY  (contact);MARTIN, LISA DANIELLE;NELSON, LEONELA

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: active control;Address;Age;age group;Alaska Native;Alaska Native Women;Ally;American Indians;Anxiety;anxiety symptoms;Area;behavioral health;budget impact;Caregivers;Caring;Cessation of life;Child;Child Rearing;Chronic;Communities;community advisory board;community engagement process;Community Participation;community setting;cost;cost effectiveness;cost estimate;Country;COVID-19 pandemic;cultural competence;depressive symptoms;design;Development;Diagnostic;Discrimination;Disparity;Distress;early childhood;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;Elements;Emotional;Enrollment;evidence base;Evidence based practice;experience;Family;family support;Feedback;Foundations;Funding;Genocides;Goals;Growth;Health;Health Services;Heterogeneity;high risk;Home;Home visitation;Hybrids;implementation barriers;implementation design;implementation facilitators;implementation strategy;implementation/effectiveness;incremental cost-effectiveness;Indigenous;indigenous community;Individual;Inequity;Institutional Racism;interest;intergenerational;Intervention;Kinship Networks;Maternal Health;Measures;Mediator;member;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;mortality;Mothers;NIH Program Announcements;novel;Nutritional;Nutritional Support;Outcome;Parents;Participant;perinatal mental health;Personal Satisfaction;Premature Mortality;Prevention;Prevention approach;Prevention program;Prevention strategy;preventive intervention;primary caregiver;primary outcome;Primary Prevention;Process;programs;protective factors;Psyche structure;Randomized;reduce symptoms;reduced substance use;Research;Research Personnel;resilience;response;Risk;Role;scale up;Secondary Prevention;Services;skills;Source;Spirituality;substance misuse;substance use;Substance Use Disorder;Suicide;Supervision;Symptoms;System;Testing;theories;Therapeutic;therapy design;Training;Trauma;tribal community;Tribes;United States;Violence;Work

PROJECT_TITLE: Family Spirit Strengths: A home visiting strategy to support parents and caregivers with mental distress and substance misuse


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE The proposed project will deliver a comprehensive set of WGS from persons of African, European, and to a lesser extent Native Brazilian ancestry, and their associations with AD/ADRD clinical and neuropathologic traits. These unique data will be shared with the wider aging and dementia research community and have a strong and sustained impact on the field.

PI_NAMEs: BENNETT, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;Admixture;admixture mapping;African;African ancestry;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Black Populations;Blood;Brain;Brazil;Budgets;causal variant;Cerebrovascular Disorders;Clinical;Clinical Data;Cognition;cohort;Collaborations;Communities;Data;Dementia;DNA;European;Genes;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Goals;hippocampal sclerosis;Latinx;Length;Lewy Body Disease;Linkage Disequilibrium;Maps;Mitochondrial DNA;Molecular;neuropathology;novel;Participant;Pathologic;Pathology;Persons;Phenotype;prospective;protein TDP-43;Proteins;Public Health;public health priorities;rare variant;Research;response;Sampling;sex as a biological variable;Silicon Dioxide;Source;telomere;Testing;Tissues;trait;Variant;whole genome;Work

PROJECT_TITLE: Whole Genome Sequencing and Admixture Analyses of Neuropathologic Traits in Diverse Cohorts in USA and Brazil

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(55)R]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: The proposed research seeks a better understanding of the underpinnings of macrophages responses that promote plaque progression, plaques instability, and plaque regression that causes catastrophic cardiovascular disease. We can leverage this knowledge to develop novel, innovative technologies to reduce cardiovascular disease burden in America.

PI_NAMEs: WOOLARD, MATTHEW DALE (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Anti-Inflammatory Agents;Arterial Fatty Streak;atheroprotective;Atherosclerosis;burden of illness;Cardiovascular Diseases;Cardiovascular system;Cause of Death;cell growth regulation;Cells;Ceramides;Cessation of life;Chronic;cost;Data;defined contribution;Event;experimental study;Failure;fatty acid metabolism;Fatty Acids;Genetic Transcription;Growth;Immunosuppression;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammation Process;Inflammatory;Inflammatory Response;innovation;innovative technologies;insight;Interleukin-4;Knowledge;Laboratories;lipid metabolism;Lipids;lipine;Macrophage;Maps;Mediating;Medical;Metabolic;Metabolic Pathway;Metabolism;Modeling;mouse model;Movement;Mus;Myelogenous;Necrosis;Nonesterified Fatty Acids;novel;oxidation;Pathologic;Pathway interactions;Peritonitis;Phagocytosis;Phosphatidate Phosphatase;Process;programs;Proteins;Regulation;Repression;Research;Resolution;response;restoration;Sphingolipids;Stimulus;Techniques;Testing;Therapeutic;therapeutic target;Toxic effect;transcription factor;Zymosan

PROJECT_TITLE: Lipin-1 transcriptional coregulatory activity promotes macrophage pro-resolving response

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Suicide is among the leading causes of death in the US (the second leading cause of death among those 15- 34 years). Approximately 50% of those who die by suicide visit a healthcare provider in the month before they die (often to an emergency department of inpatient psychiatric unit); however, current clinical methods have proven insufficient to reduce the rate of suicide. The proposed Center will implement our most innovative and effective suicide prediction and prevention methods in these settings and rigorously test their ability to decrease the rate of suicidal behavior.

PI_NAMEs: NOCK, MATTHEW K;SMOLLER, JORDAN W (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Accident and Emergency department;acute care;adaptive intervention;Adherence;Adolescent;Algorithms;alternative treatment;Behavior;biomedical informatics;Biometry;Boston;career;Caring;Cause of Death;Cessation of life;Clinical;clinical care;clinical decision support;clinical decision-making;clinical practice;Collaborations;Communities;community building;community partners;community partnership;computer science;Country;Data;Data Reporting;Data Science;Data Scientist;Decision Making;Dedications;Development;digital;digital platform;Economics;Education;effective therapy;effectiveness testing;Electronic Health Record;Emergency Department patient;Emergency department visit;Evaluation;General Hospitals;Goals;Grant;health care settings;health data;Health Personnel;Health system;Healthcare Systems;high risk;Hospital Administration;Hospitalization;Hospitals;implementation efforts;improved;innovation;innovative technologies;inpatient psychiatric settings;inpatient psychiatric treatment;Inpatients;Intervention;Learning;machine learning algorithm;machine learning prediction algorithm;Massachusetts;medical schools;member;Methods;minority children;novel;outreach;Patient risk;Patient Self-Report;Patients;Persons;population health;practice setting;predictive modeling;Prevention;Probability;programs;psychiatric inpatient;Psychiatry;Psychology;Public Health Schools;Randomized;randomized trial;Research;Research Personnel;Research Project Grants;Risk;risk prediction;risk stratification;Safety;Scientific Advances and Accomplishments;Scientist;social health determinants;Societies;statistics;Structure;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Target Populations;Technology;Testing;therapy development;Time;tool;Training;Translating;treatment optimization;trial design;Universities;Vision;Visit;Woman;Work

PROJECT_TITLE: Center for Suicide Research and Prevention


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Mental Health;Prevention;Suicide;Suicide Prevention

PI_NAMEs: SMOLLER, JORDAN W (contact)

PROJECT_TERMS: Address;Algorithms;Arts;Automobile Driving;Behavioral;Bioethics;career development;Career Mobility;clinical decision support;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community partners;Development;diversity and equity;Ensure;evidence base;experience;Faculty;Feasibility Studies;Funding;Future;Grant;Growth;Health system;Healthcare;Healthcare Systems;implementation research;implementation science;Individual;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;Investigation;Jordan;Learning;Lived experience;medical schools;Medicine;meetings;Mental Health;Methods;Newsletter;novel;novel strategies;operation;outreach;Practice based research;Prevention;Prevention program;Prevention Research;Process;program dissemination;Program Evaluation;programs;Public Health Schools;Public Sector;Publications;recruit;Research;Research Personnel;Research Project Grants;risk stratification;Scholars Program;Science;Series;Shapes;Structure;suicidal risk;Suicide;Suicide prevention;symposium;System;tool;Training;Universities;web site;webinar;Work

PROJECT_TITLE: Center for Suicide Research and Prevention - Administrative Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: Dr. Aaron D. Fox is an addiction medicine physician, experienced mentor, and established clinical scientist who seeks to expand mentorship of early-stage investigators in patient-oriented research on opioid use disorder, HIV, and marginalized populations. This proposal describes career development activities in 3 areas (mentorship; internet-mediated HIV prevention research; drug policy leadership) and a new project studying an innovative internet- based mail delivery syringe service program. In the context of the current opioid epidemic, mentoring early-stage investigators in these critical areas will have broad public health impact.

PI_NAMEs: FOX, AARON D (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Advertisements;Advisory Committees;AIDS prevention;Area;Award;Baseline Surveys;Behavior;Black Populations;Black race;Buprenorphine;buprenorphine treatment;career;career development;Characteristics;chronic pain;chronic pain patient;Client;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Treatment;Clinical Trials;cohort;Collaborations;college;Complement;cost effectiveness;County;COVID-19;Data;Dedications;Diagnostic Reagent Kits;Disease Outbreaks;Dose;Education;Effectiveness;efficacy testing;eligible participant;Emergency Situation;Enrollment;Environment;Equipment;evidence base;Exclusion;experience;Face;Facebook;feasibility testing;follow-up;Frequencies;Fright;Future;Geographic Locations;Geography;Goals;Grant;Guidelines;Harm Reduction;Health Policy;Health Services Accessibility;Helping to End Addiction Long-term;Hepatitis C Transmission;Hepatitis C virus;high risk;HIV;HIV Infections;HIV risk;Home;Hospitalization;Hospitals;Hour;housing instability;Human immunodeficiency virus test;Imprisonment;Individual;Informed Consent;Injecting drug user;injection drug use;Injections;innovation;Internet;Intervention;Latinx;Latinx population;Law Enforcement;Laws;Leadership;Link;Longitudinal cohort study;marginalized population;Measures;Mediating;Medical;Medical center;Medicine;member;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Modeling;multidisciplinary;Naloxone;Needle-Exchange Programs;novel;opioid epidemic;opioid use disorder;Overdose;overdose risk;Participant;participant enrollment;patient oriented research;peer support;Persons;Pharmaceutical Preparations;Pharmacy facility;Physicians;Policies;Population;Prevalence;Prevention Measures;Prevention Research;prevention service;Primary Care;primary outcome;Principal Investigator;Privacy;Procedures;programs;Public Health;Puerto Rico;Questionnaires;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Behaviors;Rural;Safety;Sampling;satisfaction;Scientist;screening;Secure;Self Administration;service delivery;service programs;service uptake;Services;skills;social;social media;social stigma;sociodemographics;Source;Sterility;Surveys;Syringes;Talents;Technology;Test Result;Testing;Time;Training;Translating;Translational Research;Transportation;Twitter;Underserved Population;United States;United States National Institutes of Health;uptake;urban setting;web platform;web site;Woman;Youth

PROJECT_TITLE: Mentorship in research on opioid use disorder, HIV and marginalized populations


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Suicide;Suicide Prevention

PI_NAMEs: FOULKES, ANDREA S (contact)

PROJECT_TERMS: algorithm training;Algorithms;Bioinformatics;biomedical informatics;Biometry;Calibration;causal model;clinical decision support;clinical development;Clinical Informatics;clinical predictors;Clinical Trials;Collaborations;Communities;Complex;Computer software;Data;Data Collection;data management;data quality;data resource;Data Science;design;Development;Electronic Health Record;Engineering;Ensure;Evaluation;experience;feature selection;fitbit;Funding;General Hospitals;Goals;Healthcare Systems;Heart;high dimensionality;Hour;implementation strategy;improved;Informatics;innovation;Internet;Intervention;Investigation;Lead;Leadership;Learning;machine learning method;Manuscripts;Massachusetts;medical schools;Medicine;meetings;member;Methodology;Methods;Monitor;Multi-Institutional Clinical Trial;National Institute of Mental Health;novel;Observational Study;Online Systems;Phase;Pilot Projects;Play;Population;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;prediction algorithm;Predictive Analytics;Preparation;Prevention;Procedures;professor;Public Health Schools;Quality Control;Recording of previous events;Recurrence;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Risk Estimate;risk prediction;Role;Safety;Sample Size;Site;sound;statistical and machine learning;Statistical Data Interpretation;statistics;suicidal risk;Suicide;Suicide prevention;supervised learning;Training;transfer learning;Translations;treatment effect;United States Department of Veterans Affairs;United States National Institutes of Health;Validation;wearable data;wearable monitor;web site;Work;Writing

PROJECT_TITLE: Center for Suicide Research and Prevention - Methods Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Sleep Research

ORG_CITY: TROY

ORG_DEPT: BIOLOGY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative:  The internal body clock, our circadian rhythms, control a broad range of processes in humans, timing our sleep cycles, metabolism, the immune response, and many other physiological functions to be optimally coordinated with our persistent day/night cycle. Due to the widespread integration of circadian control over many essential biological processes, the disruption of circadian rhythms has been linked to numerous medical conditions, including chronic inflammation, metabolic disease, and cancer, making an appreciation of clock control over physiology vital to human health research. Given the strong functional conservation between the fungal, murine, and human clocks, our investigation of the fundamental mechanisms and effects of circadian post-transcriptional regulation will broaden the understanding of circadian regulation over human physiology, paving the way for the development of effective chronotherapeutics.

PI_NAMEs: HURLEY, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Architecture;Biological Clocks;Biological Models;Biological Process;Biophysics;Cell Physiology;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Complex;cost;Development;Disease;Ensure;Feedback;fitness;Gene Expression;Genetic Transcription;Goals;Health;Hour;Human;Immune;Immune response;Inflammation;Investigation;Link;Macromolecular Complexes;Malignant Neoplasms;Maps;Medical;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Molecular;molecular clock;Molecular Conformation;Multiprotein Complexes;Mus;novel;Output;Pathway interactions;Periodicity;Physiological;Physiology;Post-Transcriptional Regulation;posttranscriptional;Process;protein complex;Proteins;Regulation;Reproducibility;Research;sex;Sleep;Source;Testing;Time;Tissues;Transcriptional Regulation;Translations

PROJECT_TITLE: Investigating Circadian Post-Transcriptional Regulation.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Depression remains common in people with HIV (PWH) despite viral suppression; it has important adverse consequences including poor engagement in HIV care and poor health-related quality of life, and it is often treatment resistant. We will characterize specific gene pathways relevant to depression, potentially leading to future treatments for depression in PWH.

PI_NAMEs: ELLIS, RONALD J. (contact);YOUNG, JARED WILLIAM

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Abbreviations;adverse outcome;Age;Anhedonia;Animal Behavior;Animal Model;Animals;anti-depressive agents;Beck depression inventory;Behavior;Behavioral;Biological Markers;biological research;Biometry;Brain;brain tissue;Caring;Cells;Clinical;Clinical Data;Clinical Research;clinically significant;Cognitive;cognitive process;Collaborations;Complex;Data;Depressed mood;depressive symptoms;effective therapy;Epidemic;Estradiol;experience;Family;Female;FRAP1 gene;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genomics;Gonadal Steroid Hormones;Health;health related quality of life;High Prevalence;HIV;HIV Infections;Human;Immune;immune function;Immunity;Immunology;Individual;Inflammasome;Inflammation;Inflammatory;inflammatory marker;inhibitor;innovation;Knowledge;Link;Literature;Machine Learning;Major Depressive Disorder;male;marenostrin;Mediating;men;Mental Depression;Metabolic Marker;Metabolism;Microglia;Modeling;Molecular;Molecular Biology;monocyte;Mood Disorders;mouse model;Mus;neurobehavior;Neurologist;Neurosciences;Outcome;Pathway interactions;Persons;Population;Predisposition;Premenopause;protein expression;Proteins;Psychophysiology;recruit;Research;Research Domain Criteria;Research Personnel;Resistance;Role;Sampling;Severities;sex;Sex Differences;Signal Transduction;single-cell RNA sequencing;Testosterone;transcriptome;transcriptome sequencing;transcriptomics;translational approach;Translational Research;Viral;virology;Woman;Work

PROJECT_TITLE: Immunometabolicgene expression profiles associated with depressed mood and behavioral domains inpeople with HIV


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Princeton

ORG_DEPT: PHYSICS

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative (Public Health Relevance Statement) Gene regulatory networks underlie animal development and physiological homeostasis, and perturbations in these networks cause developmental defects and pernicious diseases such as cancer. The key to curing such conditions is to elucidate underlying mechanisms, particularly regarding transcriptional regulation. Here we propose to uncover the rules governing one of the most fundamental aspects of transcriptional control—the role of chromosome organization and nuclear architecture on the dynamics of gene activity—with the goal to control and re-engineer the transcriptional programs underlying developmental and disease processes.

PI_NAMEs: GREGOR, THOMAS  (contact);LEVINE, MICHAEL STEVEN;TOETTCHER, JARED E

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Acute;Address;Alleles;Animals;Architecture;Biological;Biological Assay;Biological Models;Biology;Boundary Elements;Cell Differentiation process;cell fate specification;Cell Line;Cell Nucleus;cell type;Cells;Cellular biology;Characteristics;Chromatin;Chromosome Structures;Chromosomes;cohesin;cohesion;Complex;Crowding;Cues;Defect;Development;Developmental Biology;developmental disease;Developmental Process;Disease;Drosophila genus;Embryo;Engineering;Enhancers;Environment;Event;fly;functional gain;gastrulation;Gene Expression;gene regulatory network;Genes;genetic manipulation;Genetic Transcription;Genome;genome-wide;genomic locus;Genomics;Goals;high resolution imaging;Homeobox Genes;Homeostasis;Image;imaging modality;implantation;in vivo;Individual;Kinetics;Light;Link;Liquid substance;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;Measurement;Measures;Membrane;Methods;Modeling;Modernization;Molecular Conformation;Monitor;Mouse Embryonic Stem Cells;Mus;novel;novel strategies;Nuclear;optogenetics;Organoids;Output;Pattern;Phase;Physical condensation;Play;Population;Process;Productivity;programs;promoter;Proteins;public health relevance;Regulatory Element;Reporter;Resolution;response;Role;spatiotemporal;Specific qualifier value;stem cell organoids;Stochastic Processes;System;Techniques;Technology;Testing;Time;Tissues;tool;Transcription Coactivator;transcription factor;Transcriptional Regulation;Visualization;whole genome

PROJECT_TITLE: Control of the 4D chromatin landscape underlying gene activity during development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

PHR: Drugs that bind a receptor named PPARγ are arguably the best for treating type II diabetes; however, they are not used as much because they cause bone fracture and weight gain. This project will produce knowledge that will help develop improved type II diabetes drugs that bind PPARγ but don’t cause harmful effects.

PI_NAMEs: HUGHES, TRAVIS SHANE (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acute;Adipocytes;Adverse effects;Affect;Affinity;Agonist;Animals;antagonist;Autoimmune Diseases;Automobile Driving;Binding;bone;Cells;Characteristics;chronic liver disease;Clinic;clinically relevant;Complex;Crystallography;Data;design;Deuterium;Development;Disease;drug development;drug discovery;Drug Prescriptions;Drug Receptors;Drug Targeting;Dyslipidemias;Encyclopedias;Evaluation;Family;Fluorescence Anisotropy;Fluorine;Fracture;fracture risk;Gene Expression Profile;Genes;Genetic Transcription;Genome;Goals;Heart failure;Human;Hydrogen;improved;improved outcome;Investments;Knowledge;Lead;Ligands;Mass Spectrum Analysis;Measures;Mediating;Metabolic syndrome;Molecular;molecular dynamics;Mus;Mutagenesis;N-terminal;Names;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Magnetic Resonance;Nuclear Receptors;Outcome;Pathway Analysis;Peptides;Pharmaceutical Preparations;Physiological;PPAR gamma;programs;Proteins;Publishing;receptor;receptor structure function;recruit;Reporting;Sales;Series;Signal Pathway;Signal Transduction;Structure;Testing;Therapeutic;Therapeutic Effect;Thiazolidinediones;transcription factor;transcriptome sequencing;Weight Gain;Work

PROJECT_TITLE: Structural definition of biased agonism in the nuclear receptor PPAR gamma.

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: Project Narrative Alaska Native Tribal Health Consortium (ANTHC), a statewide tribal health organization, will participate in multi-center clinical trials through ECHO ISPCTN with Southcentral Foundation (SCF) the largest regional tribal organization and co-manager of the Alaska Native Medical Center. We will build research capacity within the rural Alaska Tribal Health System by including the rural tribal health organization, Yukon Kuskokwim Health Corporation (YKHC), in ECHO ISPCTN clinical studies, concept proposals, and network activities. The senior investigators, including the Senior Development Leader will collaborate with the American Indian/Alaska Native Clinical and Translational Research Program (AI/AN CTRP) to mentor the Junior Faculty to assume leadership as Principal Investigator in Grant Year 3.

PI_NAMEs: HIRSCHFELD, MATTHEW J;KECK, JAMES W. (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Accident and Emergency department;Accidental Injury;Address;Adherence;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;Anthropology;Bacterial Infections;Bioethics;Biology;Budgets;Child;Child Health;Childhood;Clinical;Clinical Psychology;Clinical Research;Clinical Trials;Collaborations;Communicable Diseases;Communities;community advisory board;Community Health Services;Consultations;Data;data standards;Development;Ecology;experience;Faculty;faculty research;Food;Foundations;Funding;Future;Goals;Grant;Health;health disparity;health organization;Health Priorities;Health Services;Health Services Research;Health system;Home;improved;Individual;Indoor Air Quality;Informed Consent;Instruction;Joints;Lead;Leadership;Malignant Neoplasms;Maternal and Child Health;Medical;Medical center;Mentors;Metabolic;Multi-Institutional Clinical Trial;neurodevelopment;Nursing Research;Obesity;operation;organizational structure;pediatrician;perinatal outcomes;Policies;Principal Investigator;Process;programs;Protocols documentation;Public Health;quality assurance;Recording of previous events;Research;Research Activity;research and development;Research Design;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Training;Respiratory Tract Infections;Role;Rural;rural Alaska;rural area;Rural Developments;Scientist;senior faculty;Services;Site;study population;Suicide;Suicide prevention;Surveys;Teacher Professional Development;Time;Tobacco use;training opportunity;Translational Research;translational research program;tribal health;tribal leader;tribal organization;Tribes;Underrepresented Populations;United States National Institutes of Health;Vitamin D supplementation;Water;Work;Writing;Yukon Kuskokwim

PROJECT_TITLE: Building research capacity within tribal organizations for research to improve the health of Alaska Native children


ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a rare but lethal disease that is highly associated with bone morphogenetic protein receptor II (BMPR2) mutations. BMPR2 mediates the hypoxic cellular response, and its deficiency contributes to disease pathogenesis. Here we seek to develop therapies that rescue the aberrant hypoxic response using exogenous extracellular vesicles, and pursue strategies toward improved pharmacokinetics and therapeutic index.

PI_NAMEs: MARCIANO, DAVID P (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Animal Model;Animals;Autologous;Biodistribution;Biogenesis;biological adaptation to stress;Biology;Blood flow;BMPR2 gene;bone loss;Candidate Disease Gene;Cardiovascular system;career;career development;Cell Hypoxia;Cells;Clinical;clinical application;Collaborations;Complex;CRISPR correction;Dependence;design;Development;Disease;Disease Progression;DNA Sequence Alteration;Drug Kinetics;efficacy evaluation;Endothelial Cells;Environment;exosome;extracellular vesicles;Foundations;Friction;Functional disorder;Future;gene environment interaction;Gene Expression Profile;Genetic;Goals;Heritability;human disease;hypertension treatment;Hypoxia;Image;immunogenicity;immunoreaction;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;innovation;Institution;Integrin beta4;Investigation;Knockout Mice;Link;Lung;Mediating;Membrane Proteins;Mentors;Messenger RNA;Modeling;Molecular;multiple omics;mutant;Mutation;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathogenesis;Patients;pediatric department;Penetrance;Phase;Phenotype;Physiological;Positioning Attribute;Positron-Emission Tomography;prevent;Production;professor;Program Development;programs;Proteins;pulmonary arterial hypertension;pulmonary artery endothelial cell;Reporting;Research;Research Personnel;response;Role;shear stress;Signal Transduction;stem cells;Stress;Systems Biology;Testing;Therapeutic;Therapeutic Index;therapy development;Training;Transgenic Organisms;translational medicine;Universities;vesicular release;Work

PROJECT_TITLE: Therapeutic Rescue of a Deficient BMPR2 Hypoxic Response in Pulmonary Arterial Hypertension


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Obesity;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Heart failure with preserved ejection fraction (HFpEF) and obesity are more frequently seen in postmenopausal women, but causes of these conditions are not clear. Work proposed in this grant aims to test the overall hypothesis that P21-activated kinase 1 (PAK1) regulatory activities in the heart and the adipose tissue are governed by estrogens and that PAK1 dysregulation, due to decreased estrogen levels, affects cardiac and adipose tissue function. These studies will explain, at least in part, the higher incidence of HFpEF and obesity in women and will provide new targets for future therapies.

PI_NAMEs: ROSAS, PAOLA CECILIA (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Adipose tissue;Affect;age related;aged;Aging;Area;Award;Biophysics;Brain;Brown Fat;Cardiac;Cardiac Myosins;cardioprotection;career;Central obesity;Chicago;Data;EFRAC;Elements;ESR1 gene;Estrogen decline;Estrogen Receptors;Estrogens;Exhibits;experimental study;Family;Fatty acid glycerol esters;Fellowship;Female;Foundations;Functional disorder;Funding;Future;Gender;Goals;GPER gene;Grant;Heart;Heart failure;heart function;heart preservation;Heart Research;High Prevalence;high risk;Homeostasis;Hypertrophy;Illinois;Incidence;Kinetics;Knock-out;Knockout Mice;Learning;male;member;men;Menopause;Metabolic;Metabolism;Microfilaments;Mind;Modification;Morbid Obesity;mouse model;Mus;Myocardial dysfunction;myosin-binding protein C;novel;obese patients;Obesity;obesity treatment;older women;Organ;p21-activated kinase 1;Patients;Phosphorylation;Phosphotransferases;Physiology;Play;Postdoctoral Fellow;Postmenopause;Predisposing Factor;Premenopause;preservation;Process;Production;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;Receptor Signaling;Regulation;Relaxation;Research;Resources;response;Role;Sex Ratio;Signal Pathway;Signal Transduction;skills;stressor;Techniques;Testing;Training;Translating;Universities;Visceral;Woman;Women's prevalence;Work

PROJECT_TITLE: P21-activated kinase 1 is a novel regulator of cardiac and adipose tissue function in females


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Despite evidence linking chemotherapy treatments to cognitive impairments and accelerated aging, these phenomenon (and potential interventions) have remained understudied. This area of research would benefit greatly from the establishment of a primate model with neurological, cognitive, and aging characteristics more similar to humans. Therefore, we are proposing further characterizing brain and cognitive aging in a nonhuman primate model (Olive baboons), determining if cisplatin impairs cognitive functioning and accelerates aging as it does in human patients, and testing a promising intervention which has only been tested in mice.

PI_NAMEs: MULHOLLAND, MICHELE M (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acceleration;Address;Adult;Aftercare;Age;age acceleration;Age of Onset;age related;age related biomarkers;age related neurodegeneration;age-related disease;Aging;aging biomarker;aging brain;Alzheimer's Disease;Animal Model;Antineoplastic Agents;Area;Behavior;Biological Markers;Biology of Aging;Blood specimen;Brain;Brain imaging;Cancer Model;cancer therapy;career;Characteristics;chemobrain;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical Trials;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive function;cognitive performance;cognitive testing;Complex;Data;Dementia;density;design;Development;drug development;early onset;effective therapy;effectiveness evaluation;Effectiveness of Interventions;Elderly;experience;FDA approved;Foundations;frontal lobe;Future;Genetic;Goals;gray matter;HDAC6 gene;healthy aging;Human;Impaired cognition;improved;in vivo;inhibitor;innovation;Intervention;K-Series Research Career Programs;Link;Malignant Neoplasms;Microtubules;Modeling;Molecular;molecular marker;multimodality;Mus;Nerve Degeneration;Nervous System Disorder;neural;Neuroanatomy;Neurobehavioral Manifestations;Neurologic;Neurologic Examination;neuropathology;nonhuman primate;novel;Papio;Papio anubis;pathological aging;Pathology;Patients;Pharmaceutical Preparations;Population;preclinical study;prevent;Primates;Quality of life;Research;Research Personnel;Risk Factors;Rodent;Rodent Model;Sampling;Structure;success;Synapses;System;tau Proteins;tau-1;Techniques;Testing;Therapeutic;therapy development;Training;Translational Research;Treatment-Related Cancer;white matter

PROJECT_TITLE: Baboon model of chemotherapy-related cognitive impairment and accelerated aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cannabinoid Research;Dementia;Endocannabinoid System Research;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Therapeutic Cannabinoid Research

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The overall objective of this proposal is to develop a new, endocannabinoid-based treatment for the related but distinct inherited metabolic disorders, Type A/B and Type C Niemann-Pick disease. No treatments currently exist for the life-threatening central nervous system (CNS) manifestations of these diseases, and we will address this important unmet medical need. We will explore the mechanism(s) underlying this new treatment approach, continue to examine its efficacy using animal and cell models, and use genomic, computational and other technologies to compare the CNS pathologies and relatedness to common neurodegenerative diseases.

PI_NAMEs: SCHUCHMAN, EDWARD H. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: acid sphingomyelinase;Address;Affect;Age;Agonist;Alzheimer's Disease;anandamide;Animal Model;antagonist;Attenuated;B-Lymphocytes;blood-brain barrier crossing;Brain;brain tissue;cannabinoid receptor;Carrier Proteins;Cell model;Cell surface;Cells;Central Nervous System;Central Nervous System Diseases;Cholesterol;Cholesterol Homeostasis;Clinical;CNR1 gene;Computer Analysis;Crossbreeding;Data;Defect;Disease;Disease Progression;Down-Regulation;effective therapy;Endocannabinoids;endogenous cannabinoid system;enzyme deficiency;Enzyme Inhibitor Drugs;Enzymes;Excision;extend lifespan;FAAH inhibitor;fatty acid amide hydrolase;Gene Expression;gene expression database;Genetic;Genomics;Goals;Hydrolysis;improved;Inherited;inhibitor;insight;Knockout Mice;Life;Ligands;lipidome;Lipids;Lysosomal Storage Diseases;Lysosomes;Medical;Metabolic Diseases;Molecular;multiple omics;Mus;Neimann-Pick's Disease Type C;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurons;Niemann-Pick Diseases;novel;novel therapeutic intervention;NPC1 gene;Nuclear Pore Complex;oleoylethanolamide;palmidrol;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;pharmacologic;protective effect;Proteins;Proteomics;Rare Diseases;receptor;receptor expression;response;Role;Secondary to;Signal Transduction;Signaling Protein;Sphingolipids;Sphingomyelinase;Sphingomyelins;Surface;Systems Biology;Technology;Testing;Therapeutic Effect;Tissues;trafficking;transcription factor;transcriptome;treatment strategy

PROJECT_TITLE: Endocannabinoid-Based Treatment for the Neurologic Niemann-Pick Diseases

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Great Falls

ORG_NAME: WESTERN ASSOCIATION /FOOD/DRUG OFFICIALS

PHR: Project Narrative Western Association for Food and Drug Officials PAR-19-306 Through funding support for the Western Association of Food and Drug Officials (WAFDO) Annual Educational Conferences, this project intends to provide a venue where public health practitioners in the regulatory, industry, and academic arenas can share best practices while receiving information on current trends and emerging issues impacting public health and safety related to human and animal food, drugs, cosmetics, and medical products.

PI_NAMEs: CASTRO, LUISA  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: Western Association of Food and Drug Officials (WAFDO) Annual Educational Conference Assistance


ORG_CITY: BROOKINGS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: The relevance of this research to public health is that it will help to provide an assessment of the current state of antimicrobial resistance among bacteria that are commonly found in meat and seafood consumed by humans. The results of this study will be essential in determining parameters for antimicrobial use in the treatment of animals, and for developing “One-Health” interventions to reduce the spread of antimicrobial resistance between animals and humans.

PI_NAMEs: RUESCH, LAURA  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: Antibiotic Resistance Surveillance in Retail Meat and Seafood Samples from South Dakota and North Dakota.


ORG_NAME: MARYLAND STATE DEPARTMENT OF HEALTH

PHR: PAR-20-124, NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01)  MD Department of Health, 2020 PROJECT NARRATIVE Antibiotics have inexorably changed the landscape of public health as they play a significantly role in the treatment of infectious diseases. However, antimicrobial resistance caused by excessive or incorrect use of antibiotics has become one of the major public health issues. Foodborne pathogens can also develop resistance to certain antibiotics via the exposure of antimicrobials agents primarily from inappropriate use within agricultural practices, leading to circulation within our current food production system. These pathogens can also serve as reservoirs for antimicrobial mobile genetic elements that may transfer to other pathogens. As a result, the growing trend of antibiotic resistance of foodborne pathogens continues to elevate concerns of food safety within the United States. The main goal of the FDA NARMS cooperative agreement project with Maryland Department of Health is to isolate and characterize foodborne pathogens including Salmonella, Campylobacter sp., E. coli, Enterococcus sp., Vibrio sp., Aeromonas sp. from several retail food products purchased from stores across Maryland. After the pathogens have been isolated, they are subjected to downstream phenotypic and genotypic characterizations as well as whole genome sequencing. The isolates and data are submitted to the FDA monthly. The Maryland Department of Health, Laboratories Administration has the capability and capacity to implement the current project and future pilot projects using advanced technologies to further characterize these isolates including speciation, serotyping, and whole genome sequencing.

PI_NAMEs: URBAN, SINISA  (contact)


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative  Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens in Kansas as a Part of the National Antimicrobial Resistance Monitoring System  As a key activity in combating bacterial antimicrobial resistance, the National Antimicrobial Resistance Monitoring System (NARMS) has since 1996 monitored resistance in foodborne pathogens and other enteric bacteria of food-animals at the time of animal processing; in red meat, poultry, and seafood sold in retail; and in human foodborne infections in the U.S. The monitoring in food products sold in retail is coordinated by the Food and Drug Administration – Center for Veterinary Medicine. This project will strengthen and ensure continuation of the antimicrobial resistance monitoring in food products retailed in Kansas, which is one of the major food producing states. 1

PI_NAMEs: KITTANA, HATEM ;SOUZA-NETO, JAYME A. (contact)


ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

ORG_STATE: MN

PHR: Project Narrative: The Minnesota Department of Agriculture (MDA) has been working with the Minnesota Department of Health (MDH), CDC, and FDA on the Retail Food Study since its inception in 2002. In Minnesota, MDA and MDH are culturing fresh meats from retail locations for Salmonella, fresh poultry for Campylobacter and participating in the seafood pilot study. This study has contributed substantial data to our understanding of the species, serotypes, and antimicrobial resistance types of Campylobacter and Salmonella found in various retail meats and has helped guide foodborne disease outbreak investigations where meats may have been the source of infection in humans.

PI_NAMEs: BINDERT, BRYANNE  (contact)

PROJECT_TITLE: NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CAPE TOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: DESMOND TUTU HIV FOUNDATION

PHR: PROJECT NARRATIVE The Khulani Siphile Siphuhle Training Program (KiSS-TP) will to train South African researchers from historically disadvantaged institutions (HDIs) of Eastern Cape Province in HIV research among adolescents, men, and those with co-morbid TB or Mental Health. We will offer intensive, mentored PhD training to select Masters-level faculty and staff at University of Fort Hare (UFH), Walter Sisulu University (WSU) and the Desmond Tutu Health Foundation’s (DTHF) Eastern Cape office; UFH and WSU are two of South Africa’s eight designated HDIs. We will also strengthen PhD training capacity through professional and career development of UFH and WSU faculty. Consortium include: DTHF, UFH, WSU, University of Cape Town & University of California Global Health Institute.

PI_NAMEs: BEKKER, LINDA-GAIL GAIL;COHEN, CRAIG R;MEDINA-MARINO, ANDREW  (contact);OLADIMEJI, OLANREWAJU ;VAN NIEKERK, LEON

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academic support;Address;adolescent health;aged;Area;Behavioral;California;Caring;Cities;comorbidity;Country;Development;Disadvantaged;Doctor of Philosophy;Eastern Africa;Economics;Ensure;Environment;Epidemic;Faculty;Foundations;global health;Hares;Health;health inequalities;Health trends;Historically Black Colleges and Universities;HIV;HIV/TB;Incidence;Inequity;Institution;Investments;male health;Mental disorders;Mental Health;Mentors;next generation;Outcome;Persons;Population;Prevalence;Prevention;programs;Province;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;segregation;skills;social;South Africa;Surveys;Training;Training Programs;United States;Universities

PROJECT_TITLE: Khulani Siphile Siphuhle Training Program in South Africa (KiSS-TP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: We are experiencing an antimicrobial resistance crisis, with some pathogens becoming resistant to all available antibiotics. In this project, we introduce a novel discovery platform to efficiently identify antibiotics from environmental bacteria. This project will lead to badly needed compounds to fight important multidrug- resistant pathogens, and to treat chronic diseases.

PI_NAMEs: LEWIS, KIM  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Actinobacteria class;Animal Model;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Binding Proteins;Biodiversity;Biological Assay;Candida albicans;Cell Wall;Cells;Chronic Disease;Cryoelectron Microscopy;cytotoxicity;Data;Detection;Diffusion;Dose;Encapsulated;Enterobacter;Enterobacteriaceae;Escherichia coli;Eukaryotic Cell;experience;fighting;Gram-Negative Bacteria;Growth;high throughput screening;In Situ;In Vitro;in vivo;Incubated;Industry;Infection;Klebsiella pneumoniae;Label;liquid chromatography mass spectrometry;Mammalian Cell;Membrane Proteins;Methods;Micro Electron Diffraction;Microfluidic Microchips;Microfluidics;Modality;multi-drug resistant pathogen;Natural Products;novel;Organism;pathogen;priority pathogen;Pseudomonas aeruginosa;Reporter;Resistance;resistance frequency;Salmonella typhimurium;Sampling;scaffold;screening;Sepharose;Septicemia;Signal Transduction;Soil;Sorting;Source;Stains;Staphylococcus aureus;Structure;Testing;Thigh structure;Time;Toxicity Tests;Withdrawal

PROJECT_TITLE: Discovering antimicrobials acting against MDR pathogens

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE Development and protection of the germ cells are required for human fertility. In this proposal, I aim to understand the role of the small, bioactive isoprene lipids, juvenile hormone and retinoic acids, in embryonic germline development. As both isoprene lipids are common in our environment, understanding their full impact in germline development is critical.

PI_NAMEs: BARTON, LACY J (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adolescent;Adult;animal imaging;Animals;Binding;Biogenesis;Biological Assay;Cell membrane;cell motility;Cell Physiology;Coupled;Data;Development;Disease;Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;Ensure;Environment;Enzymes;Event;Exhibits;experimental study;Fertility;Foundations;G-Protein-Coupled Receptors;Gametogenesis;Genes;Genetic Suppression;Genetic Transcription;Germ;Germ Cells;Germ Lines;Gonadal structure;Health;hormonal signals;hormone analog;Hormone secretion;House mice;Human;Image;In Vitro;in vitro Assay;in vivo;Insecta;Insecticides;insight;Institution;Invertebrates;Isoprene;isoprenoid;Juvenile Hormones;Life Cycle Stages;Lipids;male;Mammalian Cell;Mammals;Mass Spectrum Analysis;Measures;Mediating;Meiosis;Mentors;metabolomics;microscopic imaging;migration;Mission;Modeling;Mus;National Institute of Child Health and Human Development;Nature;next generation;non-genomic;novel;Oogenesis;Pattern;Persons;Pharmaceutical Preparations;Phospholipase C;Positioning Attribute;prevent;Process;Productivity;programs;Proteins;Proteomics;receptor;Receptor Activation;Regulation;Research;Research Personnel;Role;sex;sex determination;Sex Differences;Signal Transduction;Source;spatiotemporal;Spectrometry;Spermatogenesis;Structure of primordial sex cell;Testing;Time;Training;Tretinoin;Work

PROJECT_TITLE: Somatic regulation of embryonic germline dynamics by isoprenoids


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative One bottleneck in the treatment of heart attacks is the efficient retention of cellular therapies to the site of infarct, even when locally delivered via direct injection. Here we propose to develop an injectable, living drug depot that crosslinks into a scaffold at the infarct site to enhance the accumulation and retention of cardioregenerative drugs and allow for subsequent, customizable drug refills. This will personalize and improve treatment by providing opportunities for dose control and drug manipulation in response to disease evolution.

PI_NAMEs: NGUYEN, JULIANE  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Address;Affinity;Area;Arrhythmia;Basic Science;Biodistribution;bone marrow mesenchymal stem cell;Cardiac;Cardiac Myocytes;cardiac repair;Cell Therapy;cell type;Cell-Matrix Junction;Cells;Clinical Sciences;Clinical Trials;crosslink;Data;density;Deposition;design;Designer Drugs;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Engineering;Engraftment;Equilibrium;Evolution;exosome;Formulation;Genetic Engineering;Goals;Heart;Heart Diseases;heart function;Heart Injuries;Heterodimerization;immunogenic;improved;In Situ;In Vitro;Individual;induced pluripotent stem cell;Infarction;Injectable;Injections;Integrins;intravenous administration;Leucine Zippers;Link;Mediating;Mesenchymal Stem Cells;Modification;mouse model;Myocardial Infarction;Myocardial Ischemia;Myocardium;nanoparticle;novel;novel strategies;particle;Patients;Pharmaceutical Preparations;premature;prevent;Proliferating;protein crosslink;Protein Engineering;Reaction;receptor;regenerative;Reperfusion Therapy;research and development;response;Safety;scaffold;Schedule;self assembly;Site;stem cell function;Surface;System;Testing;Therapeutic;therapeutic effectiveness;Treatment Efficacy;Vertebral column

PROJECT_TITLE: Engineering a cross-linked cellular network for cardiac repair

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NORTHAMPTON

ORG_NAME: SMITH COLLEGE

PHR: PROJECT NARRATIVE Socioeconomic status (SES) is associated with differences in cognitive and academic outcomes with children from disadvantaged backgrounds performing worse than their more advantaged counterparts. The proposed studies investigate environmental and neurodevelopmental mechanisms explaining SES-related differences in executive function, with a focus on how early cognitive stimulation shapes coordination between the ventral visual stream and prefrontal cortex in young children. Study findings have the potential to inform interventions to improve cognitive and academic outcomes for children.!

PI_NAMEs: ROSEN, MAYA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Acceleration;Achievement;Adult;aged;Attention;Award;Books;career;Caregivers;Categories;Child;Child Rearing;Child Support;Childhood;Cognitive;cognitive development;cognitive function;cognitive neuroscience;Complex;conflict resolution;Development;disadvantaged background;Disparity;early childhood;early experience;effective intervention;environmental enrichment for laboratory animals;executive function;Exhibits;experience;Exposure to;Face;Faculty;Family;Feedback;functional near infrared spectroscopy;Home environment;Household;improved;Income;Individual Differences;innovation;innovative technologies;insight;Intervention;kindergarten;Language;Learning;Life;Life Experience;life span;Link;Longitudinal Studies;low socioeconomic status;Magnetic Resonance Imaging;Mediating;Mediation;member;Methods;Modeling;multimodal neuroimaging;neural;Neurocognitive;neurodevelopment;neuromechanism;novel;Outcome;Parent-Child Relations;Parents;Pathway interactions;peer;Performance;Phase;Play;Prefrontal Cortex;Process;Readiness;Research;Research Personnel;Role;school environment;Schools;Shapes;skill acquisition;Socioeconomic Status;Specificity;Stimulus;Structure;success;Supervision;Techniques;Technology Assessment;Testing;therapy development;Thick;Time;Toy;Training;ventral visual stream;Visual;Work

PROJECT_TITLE: The neurodevelopmental mechanisms linking environmental experience and executive function


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Proper replication of the genome is essential to prevent birth defects and adult diseases. This application addresses how genomic instability during development can trigger inflammation in the placenta during mid- gestation, leading to embryonic lethality in a manner that preferentially affects female embryos. If successful, this project will illuminate how genomic defects can contribute to serious obstetrical syndromes.

PI_NAMEs: SCHIMENTI, JOHN C (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Address;Adult;adverse pregnancy outcome;Affect;Alleles;Antiinflammatory Effect;Automobile Driving;Biological Assay;cell type;Cells;Complex;Congenital Abnormality;Coupled;Couples;Cytoplasm;Data;Decidua;Defect;Development;Disease;Disproportionately impacts women;DNA;DNA biosynthesis;DNA Damage;DNA Repair Gene;DNA Sequence Alteration;Embryo;Embryo Deaths;Embryonic Development;Endocrine;Environmental Exposure;Epigenetic Process;experimental study;Extravasation;Female;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;fetus cell;Functional disorder;Gases;Genes;Genetic;genetic testing;Genetic Transcription;Genome;Genomic Instability;Genomics;Genotype;Giant Cells;Goals;Growth;helicase;immune cell infiltrate;imprint;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Innate Immune System;insight;Interferons;male;MCM2 gene;micronucleus;Mitochondria;Mitochondrial DNA;Mitochondrial RNA;Modeling;Modification;Molecular;Mothers;mouse genetics;Mus;mutant;Mutant Strains Mice;Mutation;Natural Immunity;novel;Nuclear;Nutrient;nutrition;obstetrical syndromes;oocyte quality;Oocytes;Oogenesis;Organ;Outcome;Pathway interactions;Placenta;Placental Insufficiency;Polyploidy;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy loss;Pregnancy Outcome;prevent;Recurrence;replication stress;Research;RNA;RNA Virus Infections;senescence;sensor;sex;Sex Bias;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Spontaneous abortion;stem;Stimulator of Interferon Genes;Testing;Testosterone;Tissues;Translating;trophoblast;Uterus;wasting;Work

PROJECT_TITLE: Mechanisms underlying sex-dependent pregnancy outcomes caused by fetal and maternal genomic instability

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: DAVIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative This project is relevant to public health because the project will survey antimicrobial resistance among bacteria in retail foods in the state of Hawaii. The project is relevant to FDA’s mission in that the outcome of the project will enhance and sustain FDA’s surveillance and research of antimicrobial resistance in retail foods and strengthen collaborations among federal and state agencies and universities on research, detection, surveillance, and investigation of foodborne disease. 1

PI_NAMEs: LI, XUNDE  (contact)

PROJECT_TITLE: Enhancing NARMS surveillance of antibiotic resistance in retail foods in Hawaii


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative Following rotator cuff tear, injury-related physical burdens and financial costs can be substantial, and the success of surgical intervention (reattachment without future rupture) and post-surgical functional outcomes cannot currently be accurately predicted. This research will investigate the impact of clinically relevant parameters measured pre- and intra-operatively on surgical success and post-surgery shoulder function. Investigating the factors that determine surgical success and post-surgery shoulder function will improve the treatment of individuals with rotator cuff injury and support their independence and quality of life.

PI_NAMEs: DALMAN, MORGAN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Acute;Affect;Age;age related;American;Anatomy;Area;Arthritis;Articular Range of Motion;Atrophic;Caring;Characteristics;Clinical;clinically relevant;common treatment;computer framework;Contralateral;Custom;Data;Development;economic cost;Equation;experience;Fatty acid glycerol esters;Fiber;Financial cost;follow-up;functional outcomes;Future;Generations;Image;Impairment;improved;in vivo;Individual;Infiltration;injured;Injury;injury and repair;Intramuscular;Joints;Lead;Length;Limb structure;Linear Regressions;Location;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;Medical Imaging;Methods;Modeling;Monte Carlo Method;Motion;Muscle;Muscle function;muscle repair;Muscular Atrophy;Musculoskeletal;Operative Surgical Procedures;Outcome;Pain;Pain Free;Pain Measurement;Patient Selection;Patients;Performance;Physiological;Play;Postoperative Period;predictive modeling;pressure;Prevalence;Probability;Production;Quality of life;repaired;Research;Risk;Rotator Cuff;rotator cuff injury;rotator cuff tear;Rupture;Scanning;Series;severe injury;Shoulder;simulation;Stretching;success;supraspinatus muscle;Surgeon;surgery outcome;Tendon structure;Tissues;tool

PROJECT_TITLE: Understanding the Mechanical Underpinnings of Rotator Cuff Tear and Surgical Repair


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE The Management and Data Coordination Unit (MDCU) for the Pancreatic Cancer Detection Consortium (PCDC) provides support toward collaborative efforts to improve early detection of pancreatic ductal adenocarcinoma. This collaborative support includes activities such as: study design, protocol development, statistical analysis, coordination and data management. Other PCDC MDCU activities include: coordination and support toward biorepository building; and organizational and logistics support for PCDC activities.

PI_NAMEs: OBERG, ANN LAURA (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adherence;Administrative Coordination;biobank;Biological Markers;biomarker discovery;biomarker validation;Biometry;Blinded;Cancer Detection;case control;Clinic;clinically relevant;cohort;Collaborations;Communication;Communities;Consultations;Data;Data Analyses;Data Collection;Data Coordinating Center;data handling;data management;Databases;Development;Diagnosis;Disease;Documentation;early detection biomarkers;Early Diagnosis;Early Intervention;Educational workshop;Enrollment;Ensure;Evaluation Studies;experience;Experimental Designs;Future;Goals;Grant;high risk;Human Resources;imaging biomarker;improved;Infrastructure;innovation;Institution;Institutional Review Boards;Knowledge;Lead;Leadership;Lesion;Logistics;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;molecular marker;Monitor;multidisciplinary;Pancreatic Ductal Adenocarcinoma;Participant;Patient Recruitments;Patients;Phase;Policies;Population;Procedures;Process;programs;progression risk;prospective;protocol development;Protocols documentation;Randomized;repository;Reproducibility;Research;Research Design;Research Personnel;research study;Resources;Role;sample collection;Sampling;screening;Secure;Site;Statistical Data Interpretation;Strategic Planning;symposium;Testing;Time;tool;Triage;United States National Institutes of Health;Update;Validation;virtual;Work

PROJECT_TITLE: Management and Data Coordination Unit for PCDC


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Estrogen;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE: In recent years, understanding the neurobiological basis for substance use disorder (SUD) has been on the forefront of scientific agendas, which has elucidated sex as a significant biological variable in vulnerability to addiction. Females represent a particularly vulnerable population in developing cocaine use disorder and circulating gonadal hormones have been elucidated as key regulators of the dopamine system, drug responses, and motivated behavior associated with SUD. Defining the factors that underlie female-specific drug responses are critical to effectively treating them; however we must first elucidate how these sex differences fit into the comprehensive framework of dopamine regulation.

PI_NAMEs: ERICKSON, KIRSTY R. (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;addiction;adverse outcome;Affect;Affinity;aged;Agonist;Analytical Chemistry;Anatomy;Area;Behavior;Behavioral;behavioral outcome;Biological;Brain;Cells;Characteristics;Chemosensitization;Cocaine;Cocaine Dependence;cocaine reward;cocaine self-administration;Cocaine use disorder;conditioned place preference;Corpus striatum structure;Data;density;direct application;Disease;Dopamine;dopamine system;dopamine transporter;dopaminergic neuron;drug action;Drug usage;ESR1 gene;Estradiol;Estrogen Antagonists;Estrogen Receptors;Estrus;Evidence based intervention;Exhibits;experience;experimental study;Female;Foundations;Goals;Gonadal Hormones;GTP-Binding Proteins;Health;illicit drug use;Imaging Techniques;Learning;Link;male;Measures;Mediating;Mediator;Mental disorders;mesolimbic system;Molecular;Monitor;motivated behavior;Motivation;Mus;neural circuit;Neurobiology;neurotransmission;Nucleus Accumbens;optical imaging;Optics;Ovarian hormone;Periodicity;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Pharmacotherapy;Predisposition;presynaptic;Presynaptic Terminals;Process;proliferative phase Menstrual cycle;psychostimulant;receptor;Receptor Activation;Regulation;Reporting;Research;Resolution;response;Rewards;Rodent;Role;Sampling;Scanning;sex;sex as a biological variable;Sex Differences;Signal Transduction;Slice;Social outcome;Stimulant;Substance Use Disorder;Surveys;System;Techniques;training opportunity;uptake;Ventral Tegmental Area;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Estrogen receptor regulation of cocaine effects on dopamine terminals


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Compelling reasons exist to both aggressively evaluate injured children for intra-abdominal injuries (IAI) and to limit abdominal CT evaluation to solely those at non-negligible risk. The focused assessment sonography for trauma (FAST) examination can help focus patient evaluation in just this manner by potentially decreasing CT use in low risk children, and therefore the overall objectives of this proposal are 1) to determine the efficacy of using the FAST examination during the initial evaluation of children with blunt abdominal trauma, and 2) to identify factors associated with abdominal CT use in children considered very low risk for IAI after a negative FAST examination. The long-term objective of the research is to determine appropriate evaluation strategies to optimize the care of injured children, leading to improved quality of care and a reduction in morbidity and mortality.

PI_NAMEs: HOLMES, JAMES F. (contact);KUPPERMANN, NATHAN

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Abdomen;abdominal CT;Abdominal Injuries;Adult;Applied Research;arm;Caring;Cessation of life;Child;Childhood;Childhood Injury;Clinical;Consensus;Data;Decision Making;Diagnosis;efficacy evaluation;Emergency Care;Emergency Department evaluation;Emergency research;Enrollment;Evaluation;Frequencies;Hemorrhage;implementation design;implementation trial;improved;injured;Intra-abdominal;intraperitoneal;Ionizing radiation;Liquid substance;Malignant Neoplasms;Meta-Analysis;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Observational Study;Operative Surgical Procedures;Patient Care;patient safety;Patients;pediatric emergency;Physicians;Population;provider behavior;Quality of Care;Radiation;Radiation exposure;radiation risk;Randomized, Controlled Trials;Recording of previous events;Research;Research Priority;Risk;Role;Sample Size;Scanning;Site;Symptoms;System;Trauma;Ultrasonography;ultrasound;X-Ray Computed Tomography

PROJECT_TITLE: A randomized controlled trial of abdominal ultrasound (FAST) in children with blunt torso trauma

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]