NIH_SPENDING_CATS: Bioengineering

ORG_CITY: STONY BROOK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: We will develop a novel approach to simulations of large multi-component protein systems, which may pave the way towards effective atomistic models of molecular interactions in the cell. .

PI_NAMEs: KOZAKOV, DMYTRO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Agreement;Algorithms;Alzheimer's disease model;Aprotinin;Area;Award;Binding;Biological Models;Biological Products;Bovine Serum Albumin;Capsid;Cell Physiology;Cells;Cellular biology;Collaborations;Complex;Crowding;Data;Development;Disease;Erythrocytes;Evaluable Disease;Evaluation;experimental group;experimental study;flexibility;Formulation;Fourier Transform;gamma-Crystallins;Goals;Grant;Hemoglobin;Image Compression;improved;innovation;insight;Liquid substance;Mass Spectrum Analysis;Memory;method development;Methods;Minor;Modeling;molecular assembly/self assembly;Molecular Conformation;molecular modeling;mouse model;multicatalytic endopeptidase complex;Multiprotein Complexes;Mycoplasma genitalium;National Institute of General Medical Sciences;novel strategies;Nucleosome Core Particle;particle;Pathway interactions;Peptides;Performance;Pharmaceutical Preparations;Property;protein aggregation;Protein Conformation;Proteins;Resolution;Rest;Sampling;self assembly;simulation;Speed;Structure;Sum;System;therapeutic development;Validation;Variant;Writing

PROJECT_TITLE: Simulation of  Multi-Protein systems

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Currently licensed influenza vaccines need to be reformulated each year and have limited efficacy against new influenza viruses that can cause severe disease and high mortality. This proposal is designed to test the hypothesis that in people who have been exposed to influenza virus, a subset of long-lived natural killer (NK) cells can specifically recognize a broad range of different influenza strains and confer protection against new influenza viruses. The outcome of these investigations will provide the rationale to harness NK cells in future universal influenza vaccines.

PI_NAMEs: JOST, STEPHANIE  (contact);REEVES, ROGER KEITH

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Adult;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Binding;Cell Physiology;Cells;Cessation of life;cross immunity;cross reactivity;Cytomegalovirus;Data;design;Development;Disease;Disputes;Effector Cell;Epitopes;Exhibits;Exposure to;Future;Genetic Transcription;Herpesviridae Infections;Human;Immune;immune function;Immunity;Immunologic Deficiency Syndromes;Immunologic Memory;Impairment;improved;in vivo;Infectious Agent;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza epidemic;influenza infection;Influenza prevention;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;Innate Immune System;innovation;insight;Investigation;Kinetics;Licensing;Ligands;Lymphocyte;Macaca;Macaca fascicularis;Maintenance;Mediating;Membrane Proteins;Memory;Modeling;Morbidity - disease rate;mortality;Mus;Natural Killer Cells;Neoplasms;neutralizing antibody;nonhuman primate;novel vaccines;Nucleoproteins;Outcome;pandemic disease;Pathogenicity;Pathway interactions;Patients;Peptides;Persons;Phenotype;Play;Population;Preventative vaccination;Primates;protective efficacy;receptor;response;Role;seasonal influenza;sensitizing antigen;Serology;Severity of illness;Specificity;Specimen;T-Lymphocyte;Testing;Time;universal influenza vaccine;Vaccinated;Vaccination;vaccine strategy;Vaccines;Variant;Viral;Viral Physiology;Virus;Virus Diseases;volunteer

PROJECT_TITLE: Heterosubtypic immunity to influenza virus mediated by MHC-E-restricted memory NK cells


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Rehabilitation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative For youth with autism spectrum disorder (ASD), emotion dysregulation (ED) has emerged as a critical area of concern, one that leads to significant negative outcomes across the lifespan, and for which few evidence based interventions exist outside of our manualized program Regulating Together (RT), an intensive outpatient program for children with ASD+ED. Animal Assisted Interventions with canines have been found to increase engagement, therapeutic alliance, satisfaction, and attention when paired with psychological interventions. In the current proposal, we seek to evaluate the potential additive effects of canine assisted therapy paired with RT in a randomized controlled trial, utilizing a multi-method assessment battery including reactivity, dysphoria, cognitive flexibility, and heart rate variability, all of which we have already demonstrated feasibility and efficacy with the ASD population in past trials, as well as session level engagement and learning to further understand the role canines have during the intervention.

PI_NAMEs: SHAFFER, REBECCA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;adolescent with autism spectrum disorder;Affect;Age;animal efficacy;animal-assisted therapy;Animals;Area;Arousal;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;Awareness;Behavior;Behavior Therapy;Canis familiaris;Cardiovascular system;caregiver stress;Caregivers;Child;Cognitive;Cognitive Therapy;college;Colorado;Control Groups;Critiques;Data;Data Collection;data standards;Distal;Drops;dysphoria;Educational Curriculum;emotion dysregulation;emotion regulation;Emotional;Emotions;Employment;Equipment and supply inventories;Evidence based intervention;executive function;experience;Family;Feeling suicidal;flexibility;follow-up;Funding Opportunities;Heart Rate;heart rate variability;hospitalization rates;Human;Hyperactivity;Impairment;improved;individuals with autism spectrum disorder;inpatient psychiatric treatment;Intervention;Intervention Studies;Knowledge;Learning;learning materials;life span;Link;Manuals;Measurement;Measures;Mental Health Services;Methods;mindfulness;minority children;Minority Groups;Modality;Modification;Motivation;National Institute of Child Health and Human Development;negative affect;Outcome;Outcome Measure;outpatient programs;Outpatients;parenting intervention;Parents;patient population;Pediatric Hospitals;peer;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Population;post intervention;Problem behavior;Process;programs;psychologic;Public Health;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Role;satisfaction;School-Age Population;Schools;secondary outcome;Site;skills;social skills;success;Symptoms;Techniques;Testing;Therapeutic;Training;Treatment Efficacy;treatment group;Work;Youth

PROJECT_TITLE: Evaluating additive effects of including canines in Regulating Together: A Group Treatment to Address Emotion Dysregulation in youth with autism spectrum disorder


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Osteoporosis;Physical Activity;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The musculoskeletal system declines with age, largely due to physical inactivity and the depletion of growth factors, which leads to muscle weakness and increased risk of bone fracture. Growth factors in the muscle-bone unit play a role in improving muscle and bone regeneration that are further enhanced when physical activity is resumed; however, little is known about the mechanisms of how muscle interacts with bone and vice versa. The purpose of this proposal is to aid in a smooth transition from pre-doctoral training on the muscle to post-doctoral training on the bone to delineate the biochemical mechanisms involved to increase muscle mass and function along with bone mass and strength, in order to improve the quality of life in the aging community.

PI_NAMEs: KOK, HUI JEAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Acceleration;Affect;Afibrinogenemia;Age;age related decline;Aging;aging population;aging related;Attenuated;Beds;Beta Cell;Biochemical;Biological Assay;Biology;bone;bone cell;Bone Density;Bone Growth;bone loss;bone mass;Bone Matrix;Bone Regeneration;Bone remodeling;Bone Resorption;bone strength;career;Cell Proliferation;Cells;Communities;Coupling;Disease;Elderly;Extracellular Matrix;Failure;Fellowship;Fibroblast Growth Factor;Florida;Foundations;Fracture;fracture risk;Goals;Growth;Growth Factor;Health;Heparan Sulfate Proteoglycan;Hindlimb Suspension;Impairment;improved;In Vitro;in vivo;Indiana;insight;Insulin-Like Growth Factor I;Intervention;Light;Liver;Mature Bone;mechanical force;mechanical load;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mediator;Mentors;mouse model;multimodality;Muscle;Muscle Contraction;Muscle Fibers;muscle form;Muscle function;muscle physiology;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscle Weakness;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;Natural regeneration;novel;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;perlecan;Phase;Physical activity;physical inactivity;Physiology;Population;Population Decreases;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process;Production;Proliferating;Quality of life;regenerative;Regenerative capacity;Regulation;repaired;Research;Resources;response;Risk;sarcopenia;Scientist;skeletal;Skeletal bone;Skeletal Muscle;Skeleton;Source;Testing;therapeutically effective;Training;Universities;Work

PROJECT_TITLE: Muscle and Bone Growth in Aging


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Sleep Research;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Moderate to vigorous intensity physical activity is known to reduce the risk of hypertensive disorders of pregnancy and other adverse pregnancy outcomes that increase future maternal cardiovascular disease risk, yet less than 25% of pregnant women meet public health activity guidelines. More than 95% of the 24-hour day is spent in sedentary behavior, sleep, or light-intensity activity; however, the impacts of these lower intensity activities on adverse pregnancy outcomes are unknown. This multi-site observational cohort study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy and examine associations with adverse pregnancy outcomes to inform guidelines and future interventions designed to improve women’s pregnancy and long-term cardiovascular health.

PI_NAMEs: WHITAKER, KARA MARIE (contact)

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: actigraphy;Adverse event;adverse outcome;adverse pregnancy outcome;Affect;American Heart Association;Behavior;Behavior assessment;behavior test;Behavior Therapy;Behavioral;Blood Pressure;Blood Vessels;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Clinical;clinically relevant;Cohort Studies;Data;Data Analyses;demographics;Development;Devices;Diabetes Mellitus;early pregnancy;Event;Failure;Foundations;Future;General Population;Gestational Diabetes;glycemic control;Goals;Growth;Guidelines;Health;health difference;Hour;Hypertension;improved;Incidence;Intervention;Intervention Studies;Iowa;light intensity;Link;Maternal Health;Measures;Medical;Metabolic;Methods;Modeling;moderate-to-vigorous physical activity;modifiable behavior;Monitor;mortality;Mothers;National Heart, Lung, and Blood Institute;novel;Obesity;observational cohort study;Outcome;Patient Self-Report;Pattern;Physical activity;Pilot Projects;poor sleep;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Pregnancy Trimesters;Pregnant Women;Premature Birth;Prevalence;primary outcome;Public Health;recruit;Research;Research Priority;response;Risk;Risk Factors;Risk Reduction;Role;secondary outcome;sedentary lifestyle;Site;Sleep;sleep pattern;sleep quality;Small for Gestational Age Infant;Statistical Methods;Subgroup;success;therapy design;Time;Universities;vigorous intensity;Woman;women's outcomes

PROJECT_TITLE: Sedentary behavior, physical activity, sleep, and cardiovascular risk in pregnancy: the Pregnancy 24/7 cohort study

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Relationship between maternal and fetal immune responses There are similarities between fetal and maternal immunologic characteristics at delivery. We will identify mediators of communication between maternal and fetal immune systems that cross the placental barrier.

PI_NAMEs: WEINBERG, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Affect;Antigen-Presenting Cells;ATAC-seq;Bioinformatics;Biology;Birth;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Characteristics;chemokine;Chronic Hepatitis B;Communication;cytokine;Diabetes Mellitus;Ensure;Epigenetic Process;Event;Exposure to;extracellular vesicles;fetal;Fetus;Flow Cytometry;FOXP3 gene;Frequencies;Funding;Genetic Transcription;Hepatitis B Infection;high dimensionality;HIV;HIV Infections;HIV-exposed uninfected infant;Hormonal;Hormones;Hospitalization;IL2RA gene;Immune;Immune response;Immune system;Immune System Diseases;Immunologics;Immunology;Infant;Infection;Instruction;Insulin-Dependent Diabetes Mellitus;Intervention;Mediator;Medical;Membrane;metabolomics;monolayer;Mononuclear;Mothers;multiple omics;nanoparticle;National Institute of Allergy and Infectious Disease;neonate;Obesity;Peripheral Blood Mononuclear Cell;Phenotype;Placenta;Placental Hormones;Plasma;Pregnancy;programs;Proteomics;Regulatory T-Lymphocyte;Resources;Risk;Scientist;small molecule;success;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;transcriptomics;Umbilical Cord Blood;Woman


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative In this project, we will study the cellular and circuit mechanisms of spatial learning, and specifically its relationship to dopamine release during body movements. This is particularly clinically relevant because dopamine signaling and spatial learning are disrupted in multiple neurodegenerative disorders. Thus, this project has the potential to illuminate the origins of spatial learning defects in neurodegenerative conditions, as well as the role of dopamine signaling abnormalities.

PI_NAMEs: WILSON, RACHEL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acceleration;Anatomy;Back;Behavior;Brain;Calcium;Calibration;cell type;Cells;clinically relevant;Cognition;cognitive process;Complex;Computer Models;connectome;Cues;Defect;design;discount;Dopamine;Dopaminergic Cell;dopaminergic neuron;Drosophila genus;Electrophysiology (science);Environmental Wind;experimental study;Feedback;fly;Genetic;Head;Image;in silico;in vivo;in vivo calcium imaging;Learning;Link;Locomotion;Maps;Memory;model organism;Monitor;Movement;Nerve Degeneration;neural network;Neurodegenerative Disorders;neuromechanism;Neurons;Organism;Positioning Attribute;Regulation;response;Rewards;Role;Sensory;Signal Transduction;Speed;Synapses;Synaptic plasticity;System;Testing;theories;Time;virtual reality environment;Visual;way finding;Weight;Whole-Cell Recordings

PROJECT_TITLE: Dopaminergic regulation of spatial learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE – OVERALL The incidences of liver cancer are increasing and disease outcome is poor. Consequently, there is an urgent need for new therapies and better preventive strategies. As age is a major risk factor for liver cancer, this PPG will investigate the mechanisms underlying age-dependence of liver cancer and use the knowledge gained to test candidate early detection and preventative approaches.

PI_NAMEs: ADAMS, PETER D. (contact);SHADEL, GERALD

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: adaptive immunity;Age;age related;age related changes;Age Years;aged;Aging;aging related disease;assessment application;Benign;Bile Acids;Biochemical Pathway;Body fat;Cholesterol;Chromatin;Chronic;chronic liver disease;Cirrhosis;combat;Coupled;Dependence;Disease;Disease Management;Disease Outcome;DNA Sequence Alteration;Early Diagnosis;Epigenetic Process;epigenome;Equilibrium;Event;Fatty Liver;Fibrosis;Geroscience;hallmarks of aging;Homeostasis;Hypertension;Immune;immune function;Immunomodulators;improved;Incidence;indexing;Inflammation;Inflammatory;Insulin Resistance;Interferon Activation;Interferons;Intervention;Knowledge;Link;Liver;liver cancer prevention;Liver diseases;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic syndrome;Metabolism;metabolome;Mitochondria;Molecular;Molecular Profiling;Natural Immunity;neoplastic;Neoplastic liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Normal tissue morphology;novel therapeutics;Organism;Pathogenicity;permissiveness;Predisposition;prevent;Prevention strategy;preventive intervention;Primary carcinoma of the liver cells;prognostication;Risk;Risk Assessment;Risk Factors;Role;senescent cell;senolytics;Severities;Signal Transduction;Sirolimus;System;Testing;Tissues;transcriptome;tumorigenic

PROJECT_TITLE: Aging as a Risk Factor and Target for Prevention of Liver Cancer


NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: ADAMS, PETER D. (contact)

PROJECT_TERMS: adaptive immunity;Advocate;Age;age related;age related changes;aged;Aging;Aphorisms;Bile Acids;Bioinformatics;Biology of Aging;California;candidate validation;Chromatin;Chronic;Collaborations;Communities;Core Facility;data sharing;Decision Making;Dedications;Early Diagnosis;Ensure;Evaluation;Face;Goals;human tissue;Immunomodulators;Incidence;innovation;Intellectual Property;Interferon Activation;Interferons;Intervention;Joints;Lead;Leadership;liver cancer prevention;Malignant neoplasm of liver;Malignant Neoplasms;Medical;meetings;member;Metabolism;Mitochondria;Molecular;mouse model;Mus;Natural Immunity;Predisposition;prevent;Prevention;Primary carcinoma of the liver cells;Progress Reports;Qualifying;Research;Resource Sharing;Resources;Rest;Risk Factors;Role;Scientist;senolytics;Signal Transduction;Sirolimus;Site;synergism;System;Testing;Tissues;tool;Training;Universities

PROJECT_TITLE: Core A: Administrative


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Young children in foster care are at high risk for behavior problems that contribute to social challenges with their caregivers and in other settings (e.g., school, daycare). The goal of this application is to evaluate the impact of the Chicago Parent Program adapted for Foster Care (CPP-FC), using a longitudinal randomized controlled trial of 300 caregivers. The findings from this study will demonstrate whether CPP-FC is effective in reducing behavior problems in young foster children and whether that contributes to reduced caregiver stress, increased caregiver confidence, and longer lengths of time that children remain with foster caregivers, avoiding unnecessary moves from one caregiver to another and improving child wellbeing.

PI_NAMEs: BEAL, SARAH  (contact)

PROJECT_TERMS: Address;adverse outcome;African American;Age;Aggressive behavior;Behavior;Behavioral;burnout;care systems;caregiver education;caregiver stress;Caregivers;Caring;Chicago;Child;Child Abuse and Neglect;Child Behavior;Child Care;Child Rearing;Child Welfare;Clinic;Clinical Trials;Day Care;design;Development;Discipline;Effectiveness;Elements;Ensure;evidence base;Evidence based program;experience;Family;family support;foster care;foster child;Fostering;Future;Gender;Goals;health care delivery;Health Care Visit;high risk behavior;Home;Household;improved;Incentives;Individual;Informal Social Control;Institution;Intervention;Latinx;Left;Length;Licensing;Low income;maltreatment;Measures;Methods;Minority;minority children;Modeling;Modification;non-compliance;Nursery Schools;parenting intervention;Parents;Play;Policies;Population;pragmatic trial;Preparation;Preschool Child;prevent;Prevention;Problem behavior;programs;public health relevance;Race;Randomized;Randomized, Controlled Trials;real world application;Recording of previous events;Reporting;response;Risk Behaviors;Role;Schools;Self Efficacy;Services;social;Source;Stress;Structure;Suspensions;synchronous delivery;Testing;Therapeutic;Time;Training;Transportation;Trauma;treatment as usual;Trust;United States;virtual platform;Youth

PROJECT_TITLE: Prevention of behavior problems among preschool children in foster care through group-based foster caregiver training at the time of placement

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Complement is a major mediator and modulator of inflammatory to transplants. The goal of this proposal is to provide the basis for rational therapeutic enhancement of the beneficial functions and modulation of proinflammatory effects of specific complement components in transplants.

PI_NAMEs: BALDWIN, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Antibodies;Antibody Therapy;antibody-mediated rejection;Apoptotic;Autoantibodies;Autoantigens;Autoimmunity;Binding;Biopsy;Blood Platelets;C1q deficiency;Cells;Chemotactic Factors;Chronic;Clinical Trials;Complement;Complement 1q;complement 1q receptor;Complement 3a;Complement 5a;Complement Activation;Complement component C1r;Complement component C1s;Complement component C5;Complement Inactivators;delayed graft function;digital;Endothelium;extracellular vesicles;Generations;Goals;Human;Immune response;immunogenic;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;inhibitor therapy;Injury;Ischemia;Isoantibodies;Kidney Transplantation;Label;Macrophage;Mediating;Mediator;Mus;Myeloid Cells;Natural Killer Cells;neutrophil;NK Cell Activation;Organ;organ injury;Organ Transplantation;Pathway interactions;Patients;Pattern recognition receptor;platelet function;preservation;Production;Publications;receptor binding;receptor function;Recovery;recruit;Reperfusion Therapy;response;Series;Serine Proteinase Inhibitors;success;Technology;Testing;Therapeutic;Transplantation;Vascular Endothelium;Vesicle;vesicular release;Work

PROJECT_TITLE: Complement regulates macrophage and platelet function in kidney transplants

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Nutrition;Prevention;Rare Diseases

PI_NAMEs: SACCO, ALESSANDRA  (contact)

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Age;age related changes;Aging;animal imaging;Animal Model;Animals;Beds;Bile Acids;Body Weight;Breeding;candidate validation;Cell Aging;Cell Transplantation;Chromatin;Clinical;Collaborations;Collection;Cytoplasm;Data;Databases;Development;Diet;dietary;Disease;DNA;DNA delivery;Down-Regulation;Early Diagnosis;Eating;Ensure;Environment;epigenome;Equipment;Gene Expression;Genetic;Genotype;Goals;Harvest;Health;Hepatocyte;Histologic;Histopathology;Human Resources;immune modulating agents;Immunomodulators;immunoregulation;in vivo;Incidence;Individual;Industry Standard;Inflammation;Infrastructure;inhibitor;Injections;interest;Interferons;Intervention;intraperitoneal;Intravenous;Investigation;Liver;liver cancer prevention;Maintenance;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;Metabolism;Microbiology;Mitochondria;Mitochondrial DNA;Molecular;Molecular Analysis;Monitor;mouse model;Mus;Natural Immunity;non-alcoholic fatty liver disease;non-genetic;novel therapeutics;old mice;Oral;Outcome;Pain;Performance;Prevention;Prevention strategy;Procedures;Regimen;Reporting;Reproducibility;Reproducibility of Results;Research Personnel;Research Project Grants;Risk Factors;Role;senolytics;Sentinel;Services;Signal Transduction;Sirolimus;skills;Soil;Stress;success;Tail;Techniques;Testing;Tissue Banks;Tissues;Training;tumor;tumor growth;Veins;Viral;viral detection;Water;Work

PROJECT_TITLE: Core B: Mouse Models of Aging and Cancer


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Data Science;Emerging Infectious Diseases;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Acute respiratory failure is a major public health problem, occurring in more than 700,000 patients in the United States each year at a cost of more than $27 billion. This project investigates new methods for combining electronic health record data with findings from embedded clinical trials to predict individualized treatment outcomes. These innovative methods for predicting treatment outcomes will inform clinical care designed to prevent and treat acute respiratory failure.

PI_NAMEs: COOPER, GREGORY F. (contact);SEYMOUR, CHRISTOPHER WARREN

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;Acute respiratory failure;Award;Bayesian Method;Big Data;Caring;clinical care;clinical trial enrollment;Clinical Trials;Companions;Conduct Clinical Trials;cost;COVID-19 patient;Critical Illness;Data;Data Science;Data Set;design;Deterioration;Electronic Health Record;electronic health record system;Enrollment;Event;Funding;Generations;Guidelines;Health system;high risk;high risk population;Hospital Mortality;improved;improved outcome;in silico;Individual;individualized medicine;innovation;Intervention;Learning;Lung;Maps;Measures;Mechanical ventilation;Methods;Modeling;Monoclonal Antibody Therapy;mortality;National Heart, Lung, and Blood Institute;novel;Operative Surgical Procedures;Outcome;Patients;Perioperative;personalized medicine;personalized predictions;Population;Postoperative Period;Prediction of Response to Therapy;prevent;Prone Position;Public Health;Randomized;randomized, clinical trials;Research Priority;Respiratory Failure;response;SARS-CoV-2 infection;Selection for Treatments;Statistical Methods;Strategic vision;Training;Translational Research;treatment as usual;treatment effect;Treatment outcome;treatment response;United States;United States National Institutes of Health;ventilation;Vision;working group

PROJECT_TITLE: Individualized Prediction of Treatment Effects Using Data from Both Embedded Clinical Trials and Electronic Health Records

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Yale University proposes to establish a Post-Baccalaureate Research Education Program (PREP) that develops a diverse pool of well-trained post-baccalaureate participants. With evidence-informed faculty and near-peer effective mentored research training and appropriate technical, operational, and professional skills development, these researchers will transition into and complete rigorous research-focused Ph.D. or M.D./Ph.D. programs in biomedical fields. The long-term goal is to expand the pool of well-trained, diverse biomedical scientists with the range of perspectives needed to address important problems in human health and disease, including health disparities.

PI_NAMEs: BENNETT, ANTON M;NEARON, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Authorship;Biomedical Research;biomedical scientist;career;Career Choice;college;Communication;Discipline;Disease;Doctor of Medicine;Doctor of Philosophy;education research;Ethics;expectation;experience;Faculty;Goals;graduate school;Health;health disparity;Hispanic-serving Institution;Historically Black Colleges and Universities;Human;Institution;Knowledge;Leadership;Measurable;Mentors;Methods;Outcome;Participant;peer;Persons;Postbaccalaureate;programs;Readiness;recruit;Reproducibility;Research;Research Design;Research Methodology;Research Peer Review;Research Personnel;Research Training;responsible research conduct;Self Direction;skill acquisition;Students;symposium;Training;Universities;verbal;Writing

PROJECT_TITLE: Yale Post-Baccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Poorly understood biological mechanisms of irritability – a feature of depression in 40-50% of adults with major depressive disorder (MDD) that is associated with poorer quality of life, more chronic course of illness, and elevated suicidal ideation – have hindered our efforts to develop novel treatments. We propose to study healthy individuals and adults with MDD in order to understand how irritability is associated with aberrant function of key brain regions at the neurocircuit level, and to identify changes in neurocircuit function that are specific to pharmacological treatment-related improvements in irritability. A better understanding of these neurocircuit mechanisms will facilitate our development of targeted treatment strategies that will reduce the suffering of indi- viduals with MDD and other mental illnesses with burdensome irritability, such as disruptive mood dysregulation disorder, generalized anxiety disorder, bipolar disorder, post-traumatic stress disorder, and borderline personal- ity disorder.

PI_NAMEs: JHA, MANISH KUMAR (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Adult women;Affect;affective neuroscience;Aftercare;aged;Aging;American;Anger;anti-depressive agents;arm;associated symptom;Attention;Behavioral;Biological;Bipolar Disorder;Borderline Personality Disorder;Brain region;career;career development;Childhood;Chronic;Clinical assessments;Clinical Research;Clinical Trials;clinically significant;cohort;Conduct Clinical Trials;Corpus striatum structure;Data;Data Analyses;Development;dopaminergic neuron;Double-Blind Method;Emotional;Enrollment;Event;expectation;experience;experimental study;Feedback;Feeling suicidal;Female;Frustration;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Generalized Anxiety Disorder;Goals;Habenula;Human;improved;Individual;individualized medicine;Infusion procedures;innovation;interest;Intravenous infusion procedures;Investigational Therapies;Ketamine;Knowledge;Major Depressive Disorder;male;Mediating;Medicine;Mental Depression;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Midazolam;Midbrain structure;Modeling;MRI Scans;neural;neural circuit;neuroimaging;Neurosciences;new therapeutic target;next generation;Noise;novel;Outcome;Outcome Measure;Pattern;Personal Satisfaction;pharmacologic;Pharmacological Treatment;Play;Post-Traumatic Stress Disorders;pre-clinical;preclinical study;programs;Psychiatrist;Public Health;Quality of life;Randomized;Research;Research Activity;Research Personnel;Resolution;response;Rest;Rewards;Role;Sampling;Scanning;severe mood dysregulation;Severities;Signal Transduction;skills;Structure;Symptoms;targeted treatment;Testing;Training;treatment effect;treatment strategy;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Elucidating the Neurocircuitry of Irritability with Ultra-High-Field Neuroimaging to Identify Novel Therapeutic Targets

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

PI_NAMEs: SHOKHIREV, MAXIM NIKOLAIEVICH (contact)

PROJECT_TERMS: Age;age related changes;Aging;aging process;ATAC-seq;Big Data;Bioinformatics;bioinformatics pipeline;Biological Aging;Biological Assay;Biology;cell type;Cells;Cellular Assay;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;ChIP-seq;Chromatin;Collection;Communication;Computer software;Custom;Data;Data Analyses;data curation;data infrastructure;data integration;data pipeline;data quality;Data Set;Databases;Dedications;Development;dietary;Disease;diverse data;Doctor of Philosophy;education resources;Epigenetic Process;epigenomics;experimental study;Functional disorder;Gene Expression;Generations;Genes;Genetic;genome browser;Genomic approach;Genomics;Goals;hallmarks of aging;high throughput screening;Human Resources;Immune;Immune signaling;Immune system;Individual;Infrastructure;Intervention;Liver;liver cancer model;liver cancer prevention;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;Manuals;Maps;Measures;member;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;multimodality;Neoplasms;Network-based;Older Population;Output;Pathway interactions;Pharmaceutical Preparations;predictive modeling;preventive intervention;Privatization;Process;programs;protein expression;Proteomics;Quality Control;Resources;Risk Factors;Role;Services;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;System;T-Cell Receptor;Testing;Tissues;tool;Training;Training and Education;transcriptome sequencing;transcriptomics;tumor;Visual;Visualization;web site;Work;Writing

PROJECT_TITLE: Core C: Integrated Cancer and Aging Bioinformatics


NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: SHADEL, GERALD  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Age;age related;age related changes;Aging;aging process;aging related;Animals;Anti-viral Response;antioxidant enzyme;Antioxidants;beta catenin;Binding Proteins;biological adaptation to stress;cancer cell;cancer initiation;Cancer Intervention;Cancer Model;cancer predisposition;Cell Death;Cell Physiology;Cell Proliferation;Cells;Chemoresistance;chromatin remodeling;Complex;Cytosol;Data;Dependence;Development;DNA;DNA Repair;Embryonic Development;Energy Metabolism;Equilibrium;extend lifespan;Functional disorder;Gene Expression;Genes;Genetic;Genomic Instability;hallmarks of aging;High Fat Diet;Human;immune cell infiltrate;Inflammation;Inflammatory;Inherited;innate immune pathways;innovation;Interferon Type I;Interferons;Intervention;Kinetics;knock-down;Knock-out;knockout gene;Knockout Mice;Liver;liver cancer model;liver cancer prevention;Liver Dysfunction;liver inflammation;Malignant neoplasm of liver;Malignant Neoplasms;Mammals;Mediating;Membrane Proteins;Metabolic;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;model organism;molecular phenotype;mouse model;multidimensional data;Mus;normal aging;novel;Nuclear;old mice;Organelles;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Pathology;Pathway interactions;pharmacologic;Phenotype;Predisposition;prevent;Process;Production;programs;Proteins;Publishing;Reactive Oxygen Species;Regimen;respiratory;response;Risk Factors;Role;Sampling;Signal Pathway;Signal Transduction;SOD2 gene;Specific qualifier value;Stimulator of Interferon Genes;Stress;Supporting Cell;System;Testing;Time;Tissues;Translating;tumor progression;Viral;Viral Oncogene;Voltage-Dependent Anion Channel

PROJECT_TITLE: Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis


NIH_SPENDING_CATS: Aging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Immunotherapy;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PROJECT_TERMS: Acute;adaptive immunity;Age;age related;aged;Aging;Antitumor Response;Automobile Driving;Autophagocytosis;Benign;Bulla;candidate selection;Cell Aging;Cell Nucleus;Cell Proliferation;cell transformation;Cells;Cellular Stress;Characteristics;Chromatin;Chronic;chronic liver disease;Cirrhosis;cytokine;Cytoplasm;Data;Diet;Disease;Disease Outcome;DNA;epigenome;Family;Fatty Liver;Fibrosis;Genes;genetic manipulation;hallmarks of aging;Hepatocyte;Human Characteristics;Immune;Immune checkpoint inhibitor;immune clearance;immunosuppressed;Immunosuppression;in vivo;Incidence;indexing;Inflammation;Inflammatory;inhibitor;Interferon Activation;Interferons;Intervention;JNK-activating protein kinase;Knockout Mice;Liver;liver cancer prevention;Malignant neoplasm of liver;Mediating;Metabolism;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Profiling;Mutation;Neoplasms;neoplastic;NF-kappa B;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;nuclease;old mice;Oncogenes;Oncogenic;Organism;Pathway interactions;permissiveness;Phenotype;Predisposition;prevent;Prevention strategy;Primary carcinoma of the liver cells;Process;programmed cell death ligand 1;Proliferating;Resistance;response;Risk;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Severities;Signal Pathway;Signal Transduction;Sirolimus;Source;Testing;Tissues;tumor;Tumor Suppressor Genes;tumor-immune system interactions;tumorigenesis;tumorigenic;Up-Regulation;Viral;Virus

PROJECT_TITLE: Project 2: Cytoplasmic chromatin fragments (CCF) as a driver of liver cancer and target for intervention during aging


NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: KAECH, SUSAN M (contact)

PROJECT_TERMS: Address;Advocate;Age;age related;age related changes;Age related pathologies;aged;Aging;aging process;aging related;anti-tumor immune response;Bile Acid Biosynthesis Pathway;Bile Acids;Bioinformatics;Cancer Etiology;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Immunity;Cessation of life;Chronic;Colon Carcinoma;combat;Data;Development;Disease;effector T cell;exhaustion;Exposure to;Functional disorder;Gene Expression;genetic signature;Goals;hallmarks of aging;Hepatocyte;Homeostasis;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immune function;immunosenescence;Immunosuppression;Immunotherapy;Impairment;Inflammation;Inflammatory;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;Intervention;Ligands;Link;Liver;liver cancer model;liver cancer prevention;liver function;Liver neoplasms;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolic syndrome;Mitochondria;mouse model;new therapeutic target;novel;Obesity;Older Population;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;Predisposition;prevent;Primary Malignant Neoplasm of Liver;Process;Production;programmed cell death ligand 1;programmed cell death protein 1;receptor;Rejuvenation;Research Personnel;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;synergism;System;T cell infiltration;T cell therapy;T-Lymphocyte;Tissues;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Up-Regulation;Virus Diseases;Work

PROJECT_TITLE: Project 3: Chronic interferon and bile acid signaling as drivers of immunosuppression in age-related liver cancer


NIH_SPENDING_CATS: Aging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: FENG, GEN-SHENG  (contact)

PROJECT_TERMS: adaptive immunity;Affect;Aflatoxin B1;Age;age related;aged;Aging;aging mechanism;aging population;aging related;Alcohol consumption;anti-PD-L1;Cell Aging;Cell Communication;Cell Physiology;cell type;Cells;Cholestasis;Chronic;chronic liver disease;Clinical Trials;Collaborations;Combination immunotherapy;comparative;Complex;cytokine;Data;Derivation procedure;design;Development;Diagnosis;Discontinuous Capillary;Disease;Disparity;DNA Damage;Double-Stranded RNA;Endothelial Cells;Epigenetic Process;Etiology;Excision;experimental study;Gene Targeting;Goals;hallmarks of aging;Hepatic;Hepatic Mass;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatocarcinogenesis;Hepatocyte;high risk;human old age (65+);IL6 gene;Immune;Immune checkpoint inhibitor;immune function;Immune response;Immunologics;Immunotherapeutic agent;Immunotherapy;indexing;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Injury;innate immune function;insight;interdisciplinary approach;Interferon Type I;Interferons;Japan;Knowledge;Liver;liver cancer model;liver cancer prevention;liver function;Liver neoplasms;Malignant - descriptor;Malignant neoplasm of liver;mathematical model;Measures;Mediating;Metabolic;Metabolic Pathway;mitochondrial dysfunction;Modality;Modeling;Molecular;mouse model;Mus;Natural Immunity;Neoplasm Metastasis;non-alcoholic fatty liver disease;novel;old mice;older patient;Outcome;Oxidative Stress;Pathogenicity;Patients;PD-1 blockade;PD-1/PD-L1;Play;Poly C;Poly I-C;Population;Predisposition;premalignant;Prevalence;Prevention;Preventive;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Primary Neoplasm;Process;Prognosis;programmed cell death ligand 1;regenerative;Reporting;resistance mechanism;Resolution;response;restoration;Risk;Risk Factors;Role;Severities;Signal Transduction;Steatohepatitis;System;Testing;theories;Therapeutic;Translating;treatment strategy;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapy


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Cell signaling is fundamental to how cells, and ultimately tissues, are formed and function during development and throughout organismal life. The Wnt signaling pathway instructs a plethora of developmental processes and is often dysregulated in disease; these signals are driven by molecules at the cell surface called Wnts and Frizzleds (Fzds). This proposal aims to characterize how the pairing of Wnt9a and Fzd9b work together to elicit a signal.

PI_NAMEs: GRAINGER, STEPHANIE LAURA (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Area;beta catenin;Cell Maintenance;Cell membrane;Cell Nucleus;Cell Physiology;Cell surface;Cells;Cellular biology;Code;Communication;Complex;Coupling;Development;Developmental Process;Disease;Epidermal Growth Factor Receptor;Event;experience;Felis catus;FZD9 gene;Genes;Genetic Transcription;Label;Lead;Life;Ligands;Link;Mammals;Membrane;Modeling;Movement;Nature;novel;Nuclear;Output;Pathway interactions;Process;programs;Proliferating;Proteins;Publications;receptor;Receptor Signaling;Regulation;Signal Transduction;Signaling Molecule;Specificity;stem cells;student mentoring;success;Surface;System;Testing;Tissues;trafficking;Transcription Coactivator;Transcriptional Activation;WNT Family Gene;WNT Signaling Pathway;WNT9A gene;Work

PROJECT_TITLE: Understanding WNT9A/FZD9 Trafficking and Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Since the early 1990s, the field of childhood obesity has known that elementary-age children gain 3-5 times more weight during their 3-month summer vacation than they do during the entire 9-month school year. Accelerated BMI gain is not a phenomenon that occurs only in elementary-age children, with suggestive, yet limited, data indicating middle and high school-age youth also exhibit accelerated BMI gain during the summer. This project will extend a well-established existing cohort to identify the impact of an understudied timeframe (summer) associated with accelerated BMI gain during a developmental period for which no information exists (adolescence).

PI_NAMEs: BEETS, MICHAEL W (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adolescence;Adolescent;Age;Automobile Driving;Behavior Therapy;Behavioral;Behavioral Sciences;Black race;Body mass index;Child;cohort;Cohort Studies;Communities;Dairying;Data;Data Collection;Decision Making;design;Development;diaries;Diet;Disparity;Eating;elementary school;Etiology;Exhibits;Family;federal poverty level;Health and Behavior in Children;Health behavior;health disparity;Height;high school;Home;Household;Income;Individual;innovation;Intervention;junior high school;Lead;Low income;Measures;Methodology;Neighborhoods;Obesity;obesity in children;obesity prevention;Overweight;Pattern;peer;Persons;Physical activity;Prevalence;Prevention;public health intervention;Research Design;School-Age Population;Schools;Science;sedentary;Sleep;social;summer program;Time;tv watching;Weight;Weight Gain;Youth

PROJECT_TITLE: Etiology of Accelerated Weight Gain during Summer vs. School in Adolescents: What's UP (Undermining Prevention) with Summer 2

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging

ORG_CITY: FORT COLLINS

ORG_DEPT: CHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative Membrane lipid peroxidation is a type of oxidative damage that accompanies senescence-associated changes in cells and related diseases, as well as the hallmark of ferroptosis, a type of cell death. However, it is unclear which chemical reactions drive the mass peroxidation of lipids confined in membranes, or it leads to the diseased state or ferroptosis. This project seeks to answer these questions by developing a fluorescence-based assay to measure the kinetics of lipid peroxidation in supported lipid bilayers.

PI_NAMEs: CHUNG, JEAN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: age related;age-related disease;Aging;Alzheimer's Disease;Apoptosis;Biological;Biological Assay;Cell Death;cell type;Cells;Cellular Membrane;Cessation of life;chemical reaction;Chemicals;combat;Disease;Enzymes;Fluorescence;Fluorescence Microscopy;Generations;Health;Heart Diseases;Impairment;Investigation;Iron;Kinetics;Lipid Bilayers;Lipid Binding;Lipid Peroxidation;Lipid Peroxides;Lipids;Lipoxygenase;Malignant Neoplasms;Measurement;Measures;Membrane;Membrane Lipids;Membrane Proteins;membrane reconstitution;Nature;Organic solvent product;Outcome;oxidative damage;Pathologic;Pathway interactions;peroxidation;Play;Process;Role;senescence;Signaling Protein;Stroke;Surface;Testing;Therapeutic

PROJECT_TITLE: Membrane reconstitution approach for the investigation of lipid peroxidation mechanisms and its pathological effects


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Since regeneration of new retinal neurons does not occur in people, trauma or diseases that destroy retinal neurons can lead to permanent visual impairment. In the last five years we have shown for the first time that it is possible to stimulate Muller glial cells to regenerate functional retinal neurons in adult mouse retina. This proposal outlines experiments to better understand the molecular mechanisms underlying the process of in vivo Muller glial mediated neurogenesis, and to determine the applicability of this approach for the treatment of retinal disease.

PI_NAMEs: REH, THOMAS A (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age related macular degeneration;Amacrine Cells;Amphibia;Animal Model;Blindness;cell regeneration;cell type;Cells;Central Nervous System;Degenerative Disorder;Development;Disease;effective therapy;Environment;experimental study;Fishes;Functional Regeneration;functional restoration;Glaucoma;Goals;HDAC4 gene;Human;in vivo;Inflammatory Response;Injury;islet;Knowledge;Macular degeneration;Mammals;Mediating;Methods;Minority;Mitotic;Molecular;molecular phenotype;Muller's cell;Mus;N-Methylaspartate;Natural regeneration;Nerve Degeneration;Nerve Regeneration;neurogenesis;Neuroglia;neuron loss;neuron regeneration;Neurons;Patients;Persons;Process;progenitor;programs;Protocols documentation;regeneration potential;regenerative;Regenerative response;regenerative therapy;Regulator Genes;repaired;Retina;Retinal Cone;retinal damage;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal regeneration;retinal stimulation;Signal Pathway;Signal Transduction;Signaling Molecule;Source;Stem cell transplant;stem cells;Testing;Time;transcription factor;Trauma;Vertebrates;Vision;Visual impairment

PROJECT_TITLE: Stimulation of Retinal Regeneration

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Impaired myocardial autophagy is a common feature of anthracycline-induced and non-ischemic cardiomyopathy. We have discovered that apolipoprotein M, a protein secreted by hepatocytes, attenuates anthracycline cardiotoxicity and enhances myocardial autophagy. This proposal tests whether the novel role of apolipoprotein M in increasing autophagic flux is dependent on its canonical role in sphingosine-1-phosphate signaling.

PI_NAMEs: JAVAHERI, ALI  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: activating transcription factor;Acute Myelocytic Leukemia;Anthracycline;anti-cancer;Antineoplastic Agents;Apolipoproteins;Attenuated;Autophagocytosis;Autophagosome;Binding;Biogenesis;Brain natriuretic peptide;Cancer Survivor;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cause of Death;Cell Survival;cell type;Circulation;Cleavage Under Targets and Release Using Nuclease;Clinical;clinically relevant;Communication;Coronary Arteriosclerosis;Coupled;Data;Diabetes Mellitus;Doxorubicin;EFRAC;Endothelium;Etiology;Exhibits;Genes;Genetic;Genetic Transcription;GTP-Binding Proteins;Heart failure;heart function;Hepatic;Hepatocyte;High Density Lipoproteins;Human;Hypersensitivity;Impairment;improved;improved outcome;innovation;knock-down;Laboratories;Link;Lipids;Lipoprotein (a);Liver;loss of function;Malignant Neoplasms;Mediating;Modeling;Molecular;mortality;mortality risk;Mus;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardium;novel;novel therapeutics;Nuclear;Nuclear Translocation;Organ;Outcome;overexpression;particle;Pathway interactions;Plasma Proteins;preservation;prevent;Process;Production;Prognosis;Protein Secretion;Risk Factors;Role;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;success;Syndrome;Techniques;Testing;Therapeutic;therapeutic development;transcription factor;Transgenic Organisms

PROJECT_TITLE: Apolipoprotein M: a novel regulator of myocardial Autophagy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative  Responses to metabolic and other stresses play critical roles in development, many diseases, and aging. This project investigates how specific defenses against reactive oxygen species (ROS), metabolic stress, and misfolded proteins are regulated so that they respond to stress and other signals appropriately, including how they influence protein oxidation to maintain cellular function, resist stress, and ensure longevity.

PI_NAMEs: BLACKWELL, T KEITH (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Aging;Biological;biological adaptation to stress;Caenorhabditis elegans;Cell Physiology;Cells;crosslink;Defense Mechanisms;Development;Dimensions;Disease;Disulfides;Endoplasmic Reticulum;Ensure;extend lifespan;FRAP1 gene;Generations;Genetic;Growth;Heat shock proteins;Homeostasis;Impairment;insight;Intervention;Investigation;life span;Lipids;Longevity;Maps;Metabolic;Metabolic stress;misfolded protein;model organism;Modeling;Mutation;Names;National Institute of General Medical Sciences;Organism;Orthologous Gene;oxidation;Oxidation-Reduction;Play;Process;Protein Isoforms;Proteins;Reactive Oxygen Species;Regulation;Research;Resistance;response;Role;Signal Transduction;Stress;System;transcription factor;Work;Xenobiotics

PROJECT_TITLE: Signaling mechanisms that detect stress and maintain homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative This application is aimed at achieving a deep understanding of a newly discovered bacterial virulence mechanism that involves the induction of an aqueous extracellular environment in infected host tissues. Because bacteria generally benefit from a moist/aqueous/mucous environment for optimal survival and multiplication, the fundamental knowledge gained from this research could stimulate parallel studies to broadly examine a new bacterial virulence paradigm for the development of innovative strategies for controlling infectious diseases in diverse eukaryotic hosts, including humans.

PI_NAMEs: HE, SHENG YANG (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 26S proteasome;ADP-Ribosylation Factors;Affect;Air;Animals;aqueous;Arabidopsis;Bacteria;Bacterial Infections;Biochemical;Biochemistry;Biological;calcium-dependent protein kinase;Cell membrane;Cells;Cellular biology;Communicable Diseases;Development;Dimensions;Disease;Early Endosome;enteropathogenic Escherichia coli;Environment;Epidermis;extracellular;Family;Gases;Genetic;Goals;Golgi Apparatus;Guanine Nucleotide Exchange Factors;Homeostasis;host microbiome;host-microbe interactions;Human;Immunity;in vivo;Infection;Infection Control;Innate Immune Response;innovation;insight;Kidney;Knowledge;Laboratories;Link;Malignant Neoplasms;Mammals;Measures;Mediating;Methods;Michigan;Microbe;microbial;Modeling;Molecular Genetics;Mouse-ear Cress;Mucous body substance;Natural Immunity;Nature;novel;Organ;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phosphorylation;Plant Leaves;Plants;prevent;Principal Investigator;Proliferating;Proteins;Pseudomonas syringae;Regulation;Research;Respiratory System;Role;Skin;Testing;Tissues;Type III Secretion System Pathway;ubiquitin-protein ligase;Universities;Vesicle;Virulence;Water;water channel

PROJECT_TITLE: Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Patient Safety;Precision Medicine;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Clinical, genetic and environmental factors that predict individual variability in response to cardiovascular therapies can help identify patients who stand to benefit or be harmed by these drugs. However, the integration of genetic predictors into treatment requires a paradigm shift based on assessment of their impact on clinical outcomes, generation of evidence of benefit vs. risk (clinical utility) and value (cost-effectiveness) and finally translation (implementation) into clinical practice. To facilitate this paradigm shift we propose to incorporate genetic information with environmental and clinical predictors to help develop patient-focused and population-based preventive and therapeutic guidelines for patients with cardiovascular disease.

PI_NAMEs: LIMDI, NITA A (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: ABCB1 gene;acute coronary syndrome;Address;African American;Age;American;Anticoagulants;Anticoagulation;Atrial Fibrillation;Award;Blood Platelets;Candidate Disease Gene;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Chronic Disease;Clinical;clinical care;clinical phenotype;clinical practice;clinical predictors;Clinical Research;collaborative environment;comorbidity;comparative;Computerized Medical Record;cost effectiveness;CYP2C19 gene;CYP3A4 gene;Doctor of Pharmacy;Doctor of Philosophy;Dose;effectiveness/implementation design;Ensure;Environmental Risk Factor;Epidemiology;European;Foundations;Funding;Future;Generations;Genes;Genetic;genetic information;genetic predictors;Genetic Variation;Genome;genome wide association study;genomic predictors;Genomics;Genotype;Goals;Grant;Guidelines;Heart failure;Hemorrhage;implementation efforts;implementation science;improved;improved outcome;individual variation;individualized medicine;Institute of Medicine (U.S.);Institution;Knowledge;knowledge translation;Leadership;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Monitor;Oral;Outcome;participant enrollment;patient oriented research;Patient Recruitments;Patients;percutaneous coronary intervention;Performance;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacogenetic variants;Pharmacogenetics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Pharmacotherapy;population based;precision drugs;precision medicine;Predictive Factor;Preventive;Productivity;programs;Prospective cohort;Publications;Publishing;Renal function;Research;Research Personnel;Resources;response;Risk;Risk Assessment;risk prediction;Role;sex;skills;supportive environment;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Training;training opportunity;Training Programs;translational framework;Translational Research;Translations;United States National Institutes of Health;Variant;venous thromboembolism;Warfarin;Work

PROJECT_TITLE: Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Inflammatory Bowel Disease;Pain Research;Sleep Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE Novel adjunctive treatments for inflammatory bowel disease (IBD) that can better manage gastrointestinal and extraintestinal symptoms, disease activity and improve quality of life are needed. Disruption of the biological (circadian) timing system worsens both gastrointestinal and extraintestinal symptoms and reduces quality of life in IBD. This pilot clinical trial will test the potential benefits of morning light treatment (to reduce circadian disruption) on symptoms, disease severity and intestinal inflammation, and results will provide a critical foundation for the potential development of morning light treatment as a safe, non-pharmacological adjunctive treatment for IBD.

PI_NAMEs: BURGESS, HELEN JULIA (contact);GOLDSTEIN, CATHY ANNE

PROJECT_TERMS: Abdominal Pain;actigraphy;Adherence;Affect;affective disturbance;Aftercare;Age;American;Biological;Biological Clocks;Biological Markers;Biological Products;biological sex;Biopsy;Body Weight decreased;chemically induced colitis;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Clinic;Clinical;Clinical Trials;Colitis;Colonic inflammation;Conduct Clinical Trials;cost estimate;Crohn's disease;Data;depressive symptoms;Development;Devices;Diarrhea;Disabling;Disease;Disease remission;disorder control;experience;Fatigue;Fibromyalgia;Flare;Foundations;Frequencies;Future;Gastroenterology;gastrointestinal;gastrointestinal symptom;gut inflammation;Health system;Healthcare;Hemorrhage;Hour;Human;Immune Targeting;Impairment;improved;improvement on sleep;indexing;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;intervention effect;Intestines;Leukocyte L1 Antigen Complex;Light;Measures;Melatonin;Mental Depression;Michigan;Mission;modifiable risk;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Operative Surgical Procedures;pain reduction;pain symptom;Participant;Patient Outcomes Assessments;Patients;Persons;Phototherapy;primary outcome;Quality of life;Questionnaires;Randomized;recruit;Rectum;Relapse;response;Restless Legs Syndrome;Risk Factors;Rodent;Sampling;Severity of illness;sex;side effect;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;standard measure;Steroids;success;Symptom Burden;symptomatic improvement;Symptoms;System;systemic inflammatory response;targeted treatment;Testing;Therapeutic;tissue injury;treatment as usual;treatment effect;treatment group;Treatment outcome;Ulcerative Colitis;Universities;wearable device;Wrist

PROJECT_TITLE: Morning Light Treatment for Inflammatory Bowel Disease: A Pilot Clinical Trial

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative A deeper understanding of human health has grown out of technologies that measure variation in both gene activity and gene sequence within cells, as well as interactions between cells. A tool capable of performing scalable spatially-resolved genome-wide sequencing deep within tissue would have a profound impact on our understanding of the biology of health and disease. In this proposal, we describe the development of such a tool and its demonstration in biological systems.

PI_NAMEs: WEINSTEIN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Bar Codes;biological systems;Biology;Brain;Cell Communication;Cell Proliferation;Cells;chemical reaction;Chromosome Mapping;deep sequencing;Development;Disease;DNA;DNA Sequence Rearrangement;Foundations;Genes;genetic technology;Genome;genome-wide;Genomics;Goals;Health;Human;Image;imaging genetics;imaging modality;Immune;Individual;Link;Measures;microscopic imaging;Microscopy;model organism;Mutation;Nucleotides;Pathology;Phylogenetic Analysis;Physiology;Positioning Attribute;Research;RNA;Somatic Mutation;Specimen;Technology;Time;tissue mapping;Tissues;tool;tumor;tumor progression;Variant;Work

PROJECT_TITLE: Volumetric spatial-genetic imaging with DNA microscopy


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Past computational and theoretical models for the biomechanics of multicellular systems have mainly focused on the collective cell behavior in flat two-dimensional monolayers. However, organ surfaces are covered with epithelial cells that are naturally curved and comprise of 3D multilayered structures. The proposed project will develop new concepts and quantitative physical models to provide an integrative biophysical understanding of: (1) collective cell behavior on curved geometries, (2) biomechanical model for the epidermis, and (3) the role of dynamically accessible nuclear morphologies in regulating epithelial proliferation.

PI_NAMEs: BI, DAPENG  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TITLE: Integrative biophysical modeling for collective tissue mechanics

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Over one third of American adults have obesity. Lifestyle interventions, the first-line treatment for this disease, do not produce lasting weight loss for most patients. Antiobesity medications can help to increase the amount and duration of weight loss when paired with lifestyle change, especially if used long term, but brand-name medications are costly and often not covered by insurance. Phentermine is a generic antiobesity medication which is affordable but only approved for short-term use. It is not known whether phentermine will be both effective and safe for long-term weight loss. We will conduct a randomized clinical trial to compare weight loss and other health outcomes for patients assigned to take phentermine or placebo for up to two years.

PI_NAMEs: PAJEWSKI, NICHOLAS M. (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: acronyms;Adult;Adverse event;American;Atherosclerosis;Basal metabolic rate;behavior change;Behavior Therapy;behavioral study;Biometry;Blood Pressure;Body mass index;Body Weight;Body Weight Changes;Body Weight decreased;Cardiac;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cessation of life;Clinical;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communication;comorbidity;cost;Data;Data Coordinating Center;data management;Databases;Dedications;Development;Diabetes Mellitus;dietary;Disease;Double-Blind Method;Drug Prescriptions;Effectiveness;Electrocardiogram;Eligibility Determination;energy balance;Energy Intake;Enrollment;Ensure;evidence base;experience;follow-up;Glycosylated hemoglobin A;Guidelines;Health;Heart Rate;Hypertension;improved;Incidence;Informatics;Infrastructure;Insurance;Intervention;Label;Life;Life Style;lifestyle intervention;Lipids;Maintenance;Manuals;Mediating;medical schools;Methodology;mortality;Multicenter Trials;Names;novel;obese patients;Obesity;obesity treatment;off-label use;Online Systems;Outcome;Participant;participant safety;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phentermine;Physical activity;Placebos;primary outcome;Procedures;Process;programs;Protocols documentation;randomized placebo controlled trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Design;Risk;Risk Factors;Security;Serious Adverse Event;sound;Statistical Data Interpretation;stem;success;Sympathomimetics;Testing;timeline;tool;treatment guidelines;United States;uptake;waist circumference;Weight;Weight maintenance regimen

PROJECT_TITLE: 2/2, Data Coordinating Center for the Long-term Effectiveness of the Anti-obesity medication Phentermine: the LEAP Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human and mouse ligaments reform with a fibrous scar after injury, leading to sharply increased risk of reinjury and osteoarthritis later in life. I plan to use the highly regenerative zebrafish as a novel model to study scar-free craniofacial ligament regeneration and identify which cells have the potential to reform the ligament as well as which genetic signals are necessary for ligament fate. In doing so, I will identify targets for future therapeutics to improve patient outcomes after acute ligament injury.

PI_NAMEs: ANDERSON, TROY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acute;Address;Adopted;Adult;Advisory Committees;ATAC-seq;Automobile Driving;Binding;Biological Assay;Biology;Biomechanics;Candidate Disease Gene;career;Cell Differentiation process;Cell Nucleus;cell regeneration;cell type;Cells;Cephalic;Chromatin;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;craniofacial;Data;Degenerative polyarthritis;Deposition;Development;differential expression;Enhancers;Epigenetic Process;experimental study;Extracellular Matrix;Failure;Fellowship;Future;Gene Expression;gene regulatory network;Genetic;Genetic Transcription;Genomic Segment;healing;Human;improved;in vivo;Injury;insight;Institution;Joint Instability;Joint repair;Joints;Knock-out;Knockout Mice;Knowledge;Learning;Life;ligament development;ligament injury;Ligaments;loss of function;Mandible;Mentorship;Mesenchymal;Mesenchyme;Modeling;Molecular Target;Morphology;multiple omics;Mus;mutant;Mutation;Natural regeneration;Neural Crest;novel;Operative Surgical Procedures;Oryctolagus cuniculus;osteogenic;overexpression;Patient-Focused Outcomes;Periosteal Cell;Periosteum;Population;Postdoctoral Fellow;Productivity;Property;Recurrence;regenerative;regenerative therapy;repair model;repaired;Risk;Scientist;scleraxis;Signal Transduction;single nucleus RNA-sequencing;skeletal;skills;Source;Specific qualifier value;stem cell fate;stem cell population;Techniques;Temporomandibular Joint;tendon development;Testing;Therapeutic;Time;Tissues;Training;transcription factor;Transcriptional Regulation;Translating;translational study;Transposase;Zebrafish

PROJECT_TITLE: Transcriptional regulation of progenitor cell fate in craniofacial ligament regeneration

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative This project will develop technology that can measure the interaction lifetimes between proteins embedded in a cell membrane. Protein interactions can cause cell signalling required for proper cell function. Prolonged or altered interactions can lead to dissregulated signalling and disease such as cancer or allergies.

PI_NAMEs: BECERRA CHAVEZ, FRANCISCO ELOHIM;LIDKE, KEITH A (contact)

PROJECT_TERMS: active control;Algorithms;Area;Bayesian Analysis;Bayesian Method;Binding;biological systems;Biomedical Research;Blinking;Cell membrane;Cell Physiology;Cells;Collaborations;Color;Computer software;Data;Data Analyses;density;Detection;Development;Diffuse;Diffusion;dimer;Disease;Dyes;Feedback;fluorophore;Goals;heterodyning;Hypersensitivity;Image;imaging approach;imaging modality;imaging system;improved;innovation;Kinetics;Label;Libraries;Light;Lighting;Malignant Neoplasms;Markov Chains;Measurement;Measures;Membrane Proteins;Methods;Microscope;Microscopy;molecular imaging;movie;Noise;novel;Optics;Paper;Parameter Estimation;particle;Pattern;Phase;Photobleaching;Photons;Process;protein protein interaction;Proteins;Publishing;Pythons;quantum;Quantum Dots;Recording of previous events;Reporting;Research Personnel;Resolution;Sampling;Scheme;Signal Transduction;single molecule;Source;Speed;Techniques;Technology;technology development;Time;Toxic effect;ultra high resolution;Uncertainty;Visualization

PROJECT_TITLE: Adaptive Tracking and Quantum Imaging for Protein-Protein Interactions

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE – OVERALL We propose a Specialized Program of Research Excellence in Pancreas Cancer at Memorial Sloan Kettering Cancer Center (MSK Pancreas SPORE). Our goal is to leverage cutting-edge molecular knowledge of pancreas biology combined with clinical innovations to advance translational research and ultimately improve outcomes for patients diagnosed with this disease.

PI_NAMEs: IACOBUZIO-DONAHUE, CHRISTINE A;O'REILLY, EILEEN MARY (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Biological Markers;Biology;biomarker development;brca gene;Cessation of life;checkpoint therapy;Clinical;Clinical Management;Clinical Research;Clinical Trials;Collaborations;Complex;cytotoxic;Cytotoxic Chemotherapy;Development;Diagnosis;Disease;Disease remission;DNA Repair;Early Diagnosis;Epidemiology;experience;Fluorouracil;gemcitabine;Gene Expression Profiling;gene repair;Genetic;Genomics;Germ Lines;Goals;Image;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;immunogenic;Immunologics;Immunotherapy;improved;improved outcome;ineffective therapies;innovation;insight;Interleukin Activation;Investigation;irinotecan;Knowledge;Laboratory Research;Leucovorin;Lymphocyte Subset;Lymphoid Cell;Malignant neoplasm of pancreas;Memorial Sloan-Kettering Cancer Center;Mismatch Repair Deficiency;Modality;Molecular;molecular diagnostics;Mutation;nanoliposome;Newly Diagnosed;next generation;next generation sequencing;novel;novel therapeutic intervention;novel therapeutics;Outcome;Paclitaxel;PALB2 gene;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;prospective;Public Health;repaired;Research;Resistance;response;single cell analysis;Specialized Program of Research Excellence;standard of care;Symptoms;targeted treatment;Therapeutic;therapy resistant;Tissues;Translational Research;treatment response;tumor;tumor-immune system interactions;United States

PROJECT_TITLE: The Memorial Sloan Kettering Cancer Center SPORE in Pancreas Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: NARRATIVE Not applicable.

PI_NAMEs: IACOBUZIO-DONAHUE, CHRISTINE A (contact)

PROJECT_TERMS: Administrator;authority;career;Clinical;Collaborations;Communication;Communities;Data;data management;Decision Making;Development;Doctor of Philosophy;editorial;Education;Ensure;experience;Fostering;Genomics;Goals;Grant;Human Resources;Infrastructure;Institution;Link;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Manuscripts;Medical;meetings;member;Memorial Sloan-Kettering Cancer Center;Molecular;Monitor;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;operation;Pancreas;Patient Compliance;patient privacy;Principal Investigator;Program Research Project Grants;programs;Publications;Regulation;Reporting;Research;Research Personnel;Research Project Grants;scientific organization;Services;sound;Training;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE – RP1 To address the need for more-effective treatment strategies for patients with borderline or locally advanced pancreatic cancer, we will conduct a phase II clinical trial to evaluate the efficacy of total neoadjuvant therapy with novel triplet chemotherapy followed by ablative-dose chemoradiotherapy (designed to destroy the primary tumor), given before surgery. To address the urgent need to identify biomarkers of treatment response, we will assess the potential for advanced imaging with computational analysis of CT images, functional imaging with FDG-PET, and immunoPET using a targeted agent that recognizes a specific tumor marker, as well as blood- based circulating tumor DNA to detect response to treatment, assess resectability, and predict survival. If these noninvasive biomarkers prove to be informative, they will allow customized tailoring of treatment for individual patients.

PI_NAMEs: WEI, ALICE CHIA- CHI (contact)

PROJECT_TERMS: Abdomen;Address;Adjuvant Chemotherapy;advanced pancreatic cancer;arm;Biological;Biological Markers;biomarker development;biomarker identification;Blood;Blood specimen;blood-based biomarker;CA-19-9 Antigen;Cancer Detection;candidate marker;capecitabine;Cessation of life;chemoradiation;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;Clinical Trials;Combined Modality Therapy;Computer Analysis;Correlative Study;curative treatments;Data;design;Detection;determinants of treatment resistance;Diagnosis;Disease;Disease Management;Disease Progression;Disease-Free Survival;Distant;Distant Metastasis;Dose;Early treatment;effective therapy;efficacy evaluation;Eligibility Determination;Evaluation;Event;Excision;Exposure to;fluorodeoxyglucose positron emission tomography;Fluorouracil;Fractionation;Functional Imaging;Futile Treatments;Future;gemcitabine;human monoclonal antibodies;Image;imaging modality;Imaging Techniques;ImmunoPET;improved;improved outcome;individual patient;individualized medicine;irinotecan;Knowledge;Leucovorin;Liposomes;liquid biopsy;Localized Disease;Malignant neoplasm of pancreas;Measurement;Measures;Memorial Sloan-Kettering Cancer Center;Monitor;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;oxaliplatin;Pancreatectomy;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pathologic;Patient Selection;patient subsets;Patients;Phase II Clinical Trials;phase II trial;phase III trial;predict clinical outcome;Prediction of Response to Therapy;predictive modeling;primary endpoint;Primary Neoplasm;prospective;Radiation;Radiation therapy;Radiation-Sensitizing Agents;radiomics;random forest;Recurrence;Regimen;repository;Research;Resectable;response;response biomarker;Safety;Serum;standard care;Structure;survival prediction;Systemic Therapy;targeted agent;targeted sequencing;therapy resistant;Time;Tissues;Translating;treatment effect;Treatment Protocols;treatment response;treatment strategy;Triplet Multiple Birth;tumor;tumor DNA;Tumor Markers;Tumor Tissue;Unnecessary Surgery;X-Ray Computed Tomography

PROJECT_TITLE: Total Neoadjuvant Therapy (TNT) for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Precision Medicine;Rare Diseases

PHR: NARRATIVE – RP2 Current immunotherapies are ineffective for the vast majority of patients with pancreas cancer, and novel approaches are needed to harness the role of immunotherapy in this disease. Emerging evidence suggests poly- ADP ribose polymerase inhibitors (PARPi) can render pancreas cancer immunogenic and improve response to immune checkpoint blockade in a subgroup of patients with homologous repair deficiency (HRD). An improved understanding of the tumor genetics and immunologic features that contribute to response and resistance to this therapeutic combination will guide precision immunogenomic strategies to improve outcomes for patients with pancreas cancer, including beyond those with HRD.

PI_NAMEs: O'REILLY, EILEEN MARY (contact)

PROJECT_TERMS: Aftercare;Allelic Imbalance;Antigen Presentation;Biological;Biological Assay;Biological Markers;cancer cell;Cancer Etiology;CCR;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cessation of life;Characteristics;cohort;Combination immunotherapy;Complex;Computing Methodologies;cytokine;Cytoplasm;cytotoxic CD8 T cells;cytotoxicity;Data;Dendritic Cells;design;Disease;DNA;DNA Damage;Ecosystem;FDA approved;Future;gemcitabine;Gene Mutation;Genes;Genetic;genome sequencing;Genomic Instability;genomic signature;Genomics;genotoxicity;Germ Lines;Goals;homologous recombination;homologous recombination deficiency;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunogenetics;immunogenic;immunogenicity;Immunogenomics;Immunologics;Immunotherapy;Impairment;improved;improved outcome;inclusion criteria;Infiltration;insight;Link;Loss of Heterozygosity;Maintenance;Maintenance Therapy;Malignant neoplasm of pancreas;Measurement;Memorial Sloan-Kettering Cancer Center;morphogens;Mus;Mutate;Mutation;neoantigens;neoplastic cell;novel;novel strategies;Organoids;Paclitaxel;PALB2 gene;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patient Selection;patient subsets;Patients;pembrolizumab;peripheral blood;phase II trial;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;Production;programmed cell death ligand 1;programmed cell death protein 1;prospective;radiological imaging;recruit;Rejuvenation;repaired;Reporting;Research Project Grants;Resistance;Resolution;responders and non-responders;response;Role;Sampling;Stimulator of Interferon Genes;Stress;Subgroup;T-Lymphocyte;targeted agent;telomere;Testing;Therapeutic;Tissue imaging;transcriptome;transcriptomics;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;whole genome

PROJECT_TITLE: Homologous recombination deficiency and beyond in pancreatic cancer: evaluating the regulators of response to pembrolizumab and olaparib (POLAR) from the immune and genomic perspectives


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: NARRATIVE – RP3 As all current immunotherapies fail in pancreatic cancer, new approaches are needed. We have discovered that interleukin-33 (IL33) is a novel, effective pancreatic cancer immunotherapy in preclinical models. We will now develop an IL33 drug, identify target patient cohorts and mechanisms of action, and launch a first-in-human clinical trial.

PI_NAMEs: BALACHANDRAN, VINOD P (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Albumins;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antitumor Response;Biological Markers;Biology;biomarker driven;biomarker identification;cancer immunotherapy;Cancer Patient;cancer therapy;Canis familiaris;CD8-Positive T-Lymphocytes;Cell Density;Cells;checkpoint inhibition;chemokine;Clinic;clinic ready;Clinical;Clinical Trials;Coculture Techniques;cohort;Combined Modality Therapy;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Dendritic Cells;design;Drug Delivery Systems;Drug Kinetics;Drug Targeting;first-in-human;Genetic Transcription;Half-Life;Human;immune checkpoint;Immunity;Immunologics;Immunotherapy;Infiltration;inhibiting antibody;Interleukins;Knowledge;Laboratory Study;Lead;Life Extension;Liver;Lung;lymph nodes;Lymphocyte;Lymphoid Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;Metastatic Adenocarcinoma;Modeling;Molecular;molecular subtypes;Morals;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutics;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;PD-1 blockade;Peritoneum;Pharmaceutical Preparations;Pharmacology;Phenotype;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programmed cell death protein 1;Proteins;rare cancer;receptor;Recombinant Interleukins;Recombinants;recruit;refractory cancer;Reporter;Resistance;response;Safety;Sampling;Signal Transduction;Site;Specimen;Survivors;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;Toxicology;transcriptomics;Translating;Translations;tumor;Tumor Expansion;tumor growth;Tumor Immunity;tumor-immune system interactions;Work

PROJECT_TITLE: Recombinant Interleukin-33 Immunotherapy for Pancreatic Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: NARRATIVE – BIOSPECIMEN CORE The Biospecimen Core will support the work of the Memorial Sloan Kettering Cancer Center (MSK) Pancreas SPORE by playing a critical role in the collection, annotation, and storing of all tumor samples and blood from patients with pancreatic neoplasms enrolled in research protocols at MSK. The core will provide centralized expertise in pathological diagnosis, tissue selection for molecular analysis, and interpretation of ancillary techniques to assist the translational research goals of the SPORE investigators.

PI_NAMEs: BASTURK, OLCA  (contact)

PROJECT_TERMS: adjudication;Adjuvant Therapy;American;anti-cancer research;Basic Science;biobank;Biological Assay;Biological Specimen Banks;Blood;cancer cell;Cancer Patient;Cell Line;Cell Survival;CLIA certified;Clinical;Collaborations;Collection;college;Consent;cost effective;data quality;Databases;design;Diagnosis;diagnostic value;Documentation;Effectiveness;Enrollment;Ensure;Evaluation;Excision;exome sequencing;follow-up;Formalin;Freezing;Generations;Genomics;Goals;Heterogeneity;Human;human tissue;Immunohistochemistry;Infrastructure;Institution;Laboratories;laser capture microdissection;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;Microdissection;Microscopic;Molecular Analysis;molecular diagnostics;molecular oncology;Morphology;mouse model;Mutation;Neoadjuvant Therapy;Normal tissue morphology;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Paraffin Embedding;participant enrollment;Pathologic;Pathologist;Pathology;Patient-Focused Outcomes;Patients;peripheral blood;Plasma;Play;programs;prospective;Protocols documentation;quality assurance;Quality Control;Randomized, Controlled Trials;Recording of previous events;relational database;Reproducibility;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;Role;Sampling;Serum;Services;single cell sequencing;Specimen;Standardization;System;Techniques;Therapeutic Research;Tissue Banks;Tissue Microarray;Tissue Sample;Tissues;Translational Research;Treatment Protocols;treatment response;tumor;Tumor Tissue;Work

PROJECT_TITLE: Biospecimen Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Precision Medicine;Rare Diseases

PHR: NARRATIVE – BIOSTATISTICS CORE The Biostatistics Core will provide investigators of the Memorial Sloan Kettering Cancer Center Pancreas SPORE with computational and statistical support for their research efforts, including the design and analysis of laboratory experiments, molecular profiling assays, clinical trials, and imaging studies. Its support is critical for the successful completion of all research projects in the Pancreas SPORE and will be available to support Career Enhancement and Developmental Research Program projects.

PI_NAMEs: CAPANU, MARINELA  (contact)

PROJECT_TERMS: Address;analytical method;Attention;Bioinformatics;Biological Assay;Biostatistics Core;career;Clinical Data;Clinical Research;Clinical Trials;comparison group;computerized data processing;Consult;Data;Data Analyses;Data Analytics;data format;Data Set;Dedications;design;Development;Ensure;experience;Experimental Designs;Formulation;Goals;Graph;human tissue;imaging modality;imaging study;Individual;Laboratories;laboratory experiment;Leadership;Malignant neoplasm of pancreas;Manuscripts;member;Memorial Sloan-Kettering Cancer Center;Methodology;Methods;Modification;Molecular;molecular marker;Molecular Profiling;Nature;novel;Outcome Assessment;Outcome Study;Pancreas;Population;potential biomarker;predict clinical outcome;predictive marker;Preparation;primary endpoint;Procedures;Program Research Project Grants;Protocols documentation;Publications;radiomics;Randomized;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Role;Sample Size;Sampling;Science;secondary endpoint;Statistical Data Interpretation;Statistical Methods;translational goal;treatment response;Validation;Work

PROJECT_TITLE: Biostatistics Core


PI_NAMEs: LEWIS, JASON S. (contact)

PROJECT_TERMS: anti-cancer research;Award;base;biomarker development;clinical care;Clinical Trials;Collaborations;Combined Modality Therapy;Data;Development;diversity and inclusion;Doctor of Philosophy;Eligibility Determination;Extramural Activities;Faculty;Funding;Genomics;Goals;Immunotherapeutic agent;Individual;innovation;Institution;Investigation;Islet Cell Tumor;Leadership;Malignant neoplasm of pancreas;medical schools;Memorial Sloan-Kettering Cancer Center;novel strategies;Outcome;Pancreas;pancreatic neoplasm;Participant;Patient Care;Peer Review;Pilot Projects;preference;Program Research Project Grants;programs;Publications;Qualifying;radiomics;Recording of previous events;Request for Proposals;Research;Research Personnel;Research Support;Resources;stem;success;translational cancer research;translational goal;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Women's Group

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Pregnancy;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: The proposed research is relevant to public health because the findings will have a system wide sustainable impact on the prevention of prenatal and postnatal tobacco smoking in Romania and in Central and Eastern Europe, with applications to the US and other populations. The research is also expected to have an important impact on the methodology and design of mobile technology clinical and public health interventions during the reproductive years with lifelong potential implications. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help enhance health and reduce the burdens of human illness.

PI_NAMEs: FOLEY, KRISTIE L;MEGHEA, CRISTIAN IOAN (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Abstinence;acceptability and feasibility;adaptive learning;Address;Adopted;arm;Artificial Intelligence;behavior change;Birth;Cellular Phone;Cessation of life;Clinical;Control Groups;Counseling;Couples;craving;design;Development;Disease;Eastern Europe;Effectiveness;effectiveness-implementation RCT;effectiveness/implementation hybrid;feasibility testing;Friends;General Population;Goals;Health;Health Personnel;Health system;Healthcare;Human;Individual;Institution;International;Intervention;iterative design;Knowledge;Learning;low and middle-income countries;Methodology;mHealth;Mission;mobile computing;Morbidity - disease rate;mortality;motivational enhancement therapy;novel;offspring;Outcome;Ownership;peer support;Persons;Phase;pilot trial;Population;postnatal;Postpartum Period;Pregnancy;Pregnancy Tests;Pregnant Women;prenatal;prenatal cigarette smoking;prepregnancy;Prevention;Professional counselor;programs;Psychological reinforcement;Public Health;public health intervention;Randomized;reproductive;Research;Romania;Self Determination;Series;smartphone application;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking during pregnancy;Spouses;Stress;System;telephone coaching;Testing;theories;Tobacco;tobacco control;Tobacco smoking behavior;Tobacco Use Cessation;United States National Institutes of Health;usability;video coaching;Woman;Work

PROJECT_TITLE: A Smartphone Intervention for Pregnancy Smoking Cessation with Peer Support


PROJECT_TERMS: anti-cancer research;Appointment;career;career development;Clinical;clinically relevant;Collaborations;Core Facility;design;Development;Development Plans;diversity and inclusion;Education;Educational Curriculum;Eligibility Determination;Exhibits;Faculty;Funding;Goals;health care disparity;Individual;Institution;inter-institutional;interest;Laboratories;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;medical schools;meetings;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;New York City;Pancreas;Peer Review;Physicians;Positioning Attribute;Postdoctoral Fellow;programs;Publications;Qualifying;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Support;Schedule;Scientist;skills;success;symposium;Talents;tenure track;Therapeutic;Training;Training and Education;Translating;Translational Research;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: Career Enhancement Program