ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Adipose tissue contains a network of immune cells that contribute to the metabolic changes associated with obesity and diabetes. The goal of this study is to expand our understanding of the communication pathways between several key immune cells known to reside in adipose tissue. Completing our study can reveal novel mechanisms by which adipose tissue inflammation is generated and can be suppressed.

PI_NAMEs: LUMENG, CAREY N (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: adaptive immunity;Address;Adipose tissue;Adopted;Antibodies;Antigen-Presenting Cells;Cell Communication;Cell Ontogeny;Cell Physiology;Cell Shape;Cells;Chronic;Communication;CTLA4 gene;cytokine;Data;Dendritic Cells;Diabetes Mellitus;diabetic;dietary;Disease;effector T cell;Ensure;Environment;exhaust;exhaustion;Funding;Genes;Genetic;Genetic Models;Glucocorticoids;Goals;Grant;Health;herpesvirus entry mediator;Human;Hyperactivity;IL2RA gene;Immune;Immune response;Immune system;immunoregulation;Immunosuppression;Impairment;improved;in vivo;Inflammation;Inflammatory;inflammatory milieu;Insulin Resistance;Interferon Type II;Interleukin-2;Intervention;Leukocytes;Link;Macrophage;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modeling;Morbidity - disease rate;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;Pathway interactions;Persons;pharmacologic;Predisposition;preservation;Production;programmed cell death protein 1;Proliferating;Proteins;Publishing;receptor;Regulation;Research;Resolution;respiratory;respiratory virus;restraint;Role;Sampling;Sepsis;Severity of illness;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stimulus;T cell response;T-Cell Activation;T-cell diversity;T-Cell Proliferation;T-Lymphocyte;Testing;Thinness;Time;vaccine response;Virus Diseases;Work

PROJECT_TITLE: Regulation of Adipose Tissue Inflammation By Antigen Presenting Cells


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Small molecules that modulate endocannabinoid (eCB) signaling in brain represent promising therapeutics for the treatment of neurological diseases, including drug addiction. Here we will study how the two eCB-hydrolyzing enzymes, α/β hydrolase domain-contain 6 (ABHD6) and monoacylglycerol lipase (MAGL), differentially control the stimulated production of 2-arachidonoyl glycerol (2-AG, a major eCB in brain), and its ensuing activity at cannabinoid 1 receptors (CB1R) using a genetically encoded biosensor (GRABeCB2.0) that detects real-time changes in 2-AG levels. This research will provide a comprehensive understanding of the mechanistic differences by which ABHD6 and MAGL control 2-AG-CB1R signaling in brain, a body of work that will help the development of novel therapeutics.

PI_NAMEs: STELLA, NEPHI  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 2-arachidonylglycerol;ABHD6 gene;abuse liability;Address;Adverse effects;Affect;Agonist;Applications Grants;BDKRB2 gene;Biological Models;Biosensor;Bradykinin;Brain;Cannabinoids;Cell Line;cell type;Cells;Chronic;CNR1 gene;Corpus striatum structure;Development;Drug Addiction;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Enzymes;Fluorescence Microscopy;Goals;Hydrolase;lipoprotein lipase;MAGL inhibitor;Maps;Measures;Mediating;Molecular;Monoacylglycerol Lipases;Mus;N-Methylaspartate;Nervous System Disorder;Neurons;novel;novel therapeutics;pharmacologic;postsynaptic;presynaptic;Presynaptic Terminals;Production;Property;receptor;Receptor Signaling;Research;Role;sensor;side effect;Signal Transduction;Slice;small molecule;spatiotemporal;Stimulus;Synaptic Transmission;System;Testing;Therapeutic;Time;tool;Transfection;two photon microscopy;Veratridine;Work

PROJECT_TITLE: Differential control of 2-AG’s activity at CB1R by ABHD6 and MAGL

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: KINGSTON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: QUEEN'S UNIVERSITY AT KINGSTON

ORG_STATE: ON

ORG_ZIPCODE: K7L 3N6

PI_NAMEs: DANCEY, JANET ELLEN (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adolescent and Young Adult;Adult;Brain;Breast;Canada;Cancer Biology;cancer therapy;Cell Therapy;Child;Clinical Data;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Collection;Common Terminology Criteria for Adverse Events;Data;Data Collection;data management;data quality;Data Set;data sharing;Development;Diagnosis;digital health;Eligibility Determination;Ensure;Evaluation;experience;Goals;Guidelines;Head and Neck Cancer;Health;health economics;health related quality of life;Hematology;Image;improved;Information Technology;innovation;International;Intervention;Leadership;lifestyle intervention;Lung;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;method development;Methodology;Methods;Modeling;Molecular;Monitor;Multi-Institutional Clinical Trial;novel therapeutics;Operative Surgical Procedures;Outcome;Participant;Patients;Pharmacotherapy;pharmacovigilance;Pilot Projects;Policies;Population;precision medicine;Process;prospective;Publications;rare cancer;Regulation;Reporting;Research;research clinical testing;Research Personnel;response;Role;Safety;Scientific Advances and Accomplishments;Site;Skin;Statistical Data Interpretation;statistics;System;Technology;technology development;Testing;tool;Training Programs;Translational Research;Translations;urologic;wearable device;working group

PROJECT_TITLE: Canadian Cancer Trials Group - Canadian Collaborating Clinical Trials Network: Statistics and Data Management Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Data Science;Kidney Disease;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Peripheral artery disease (PAD) affects millions of people around the world, causing decreased mobility, non- healing wounds, gangrene and amputations. Patients with chronic kidney disease have a higher risk for PAD and its complications, but relatively little is known about what treatments are effective in this population. Our project aims to narrow some of these knowledge gaps to improve PAD treatment practices for patients with chronic kidney disease.

PI_NAMEs: CHANG, TARA I-HSIN (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acceleration;Address;Affect;Age;Algorithms;Amputation;Anticoagulants;Arteries;Aspirin;Atherosclerosis;Big Data;Biometry;Blood Platelets;Blood Vessels;calcification;Cardiac;Cardiovascular Diseases;career;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;Clinical Trials;Code;cohort;cost;Data;Data Mart;Data Science;Data Set;Databases;Dedications;Diabetes Mellitus;Diagnostic;Disease;Effectiveness;Electronic Health Record;End stage renal failure;Epidemiology;Evaluation;Event;evidence base;Exclusion;experience;Future;Gangrene;General Population;Goals;health related quality of life;Healthcare;Healthcare Systems;Hemorrhage;High Prevalence;high risk;Home;Hospitalization;Hypertension;improved;Inflammation;innovation;insight;Kidney Diseases;Knowledge;Lead;Limb structure;Lower Extremity;Manuals;Medial;Medicine;Methods;Minerals;Mobility decline;Modernization;Multicenter Studies;Natural Language Processing;Nephrology;non-healing wounds;novel;Observational Study;Operative Surgical Procedures;Oral;Outcome Assessment;Patient Care;Patient-Focused Outcomes;Patients;performance tests;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Physicians;Population;Predictive Value;Procedures;programs;Quality of life;Records;Reporting;Research;revascularization;revascularization surgery;Risk Factors;Safety;Scientist;Specificity;stroke event;Subgroup;Testing;Time;Uremia;virtual

PROJECT_TITLE: Harnessing Big Data to Identify Effective Peripheral Artery Disease Treatments in Chronic Kidney Disease


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ST. THOMAS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF THE VIRGIN ISLANDS

ORG_STATE: VI

PHR: Project Narrative This project is relevant to public health because it will produce a diverse group of rigorously trained, motivated undergraduate students who will be competitive for highly selective doctoral programs and, as biomedical researchers, contribute to the quality and diversity of the scientific workforce. These talented University of the Virgin Islands students will be future leaders in addressing the health research needs of the Nation. They will contribute a unique perspective because of their cultural and socio-economic backgrounds; these perspectives will be important not only to addressing health disparities but also to breakthroughs across the scope of biomedical and behavioral sciences.

PI_NAMEs: MCSWEEN, VERLEEN ;ROGERS, LAVIDA ;STANFORD, ALICE MARGARET (contact);STOLZ, ROBERT

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Admission activity;Articulation;Behavioral;Biomedical Research;career;Career Choice;career networking;Degree program;design;Discipline;Doctor of Philosophy;Educational Curriculum;Educational workshop;Enrollment;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;improved;Institution;journal article;Measurable;meetings;Mentors;Minority;Mission;Pathway interactions;peer coaching;Population;Productivity;programs;Publishing;Reporting;Research;Research Personnel;Research Training;Scientist;skills;Structure;Students;success;summer research;support network;symposium;Time;Training;training opportunity;undergraduate student;United States Virgin Islands;Universities;verbal;Visit;Work

PROJECT_TITLE: U-RISE at the University of the Virgin Islands

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Narrative The proposed research will gain new mechanistic insights into how STING promotes dysfunctional cell-cell crosstalk involving mtDNA-containing EVs to promote cholangiocyte senescence-associated secretory phenotype, macrophage proinflammatory activation, and HSC fibrogenic activation, and consequent ductular reaction and liver fibrosis. The successful completion of the proposed research will accelerate the development of new approaches for managing biliary injury by STING inhibition.

PI_NAMEs: EKSER, BURCIN ;GLASER, SHANNON STROUD (contact);WU, CHAODONG

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;autocrine;Bile Acids;Biliary;cell type;Cells;cholangiocyte;Cholestasis;Chronic;Clinical;Critical Pathways;Cyclic GMP;Data;design;Development;Disease;ds-DNA;Endothelial Cells;experimental study;extracellular vesicles;Fibrosis;Gene Activation;Gene Expression;Gene Expression Regulation;Hepatic Stellate Cell;Hepatobiliary;Hepatocyte;Human;Immune;Inflammation;Inflammatory;Injury;innovation;insight;Knowledge;Kupffer Cells;Link;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Macrophage;Macrophage Activation;Mediator;Mitochondria;Mitochondrial DNA;Molecular;mouse model;Mus;Myeloid Cells;Natural Immunity;non-alcoholic fatty liver disease;novel;novel strategies;novel therapeutic intervention;Organoids;Oxidative Stress;paracrine;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Play;primary sclerosing cholangitis;Proliferating;Reaction;Research;response;Role;Secretin;senescence;senescence associated secretory phenotype;Signal Transduction;Signaling Protein;Stimulator of Interferon Genes;Testing;Therapeutic;Transforming Growth Factor beta;validation studies

PROJECT_TITLE: Role of STING in Cholestatic Liver Injury

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE  The molecular mechanisms via which cells measure available nutrients and, in response, make critical decisions toward their growth, proliferation and differentiation remain largely unknown. Building on our recent discoveries, the current proposal aims to determine how the mTORC1 kinase, a nutrient-responsive master growth regulator implicated in numerous human diseases, senses cholesterol to regulate organelle homeostasis and communication in cellular space and time. The resulting discoveries will illuminate fundamental rules of metabolic organization, and will point to new strategies to inhibit mTORC1 signaling and boost lysosomal catabolic functions in disease settings.

PI_NAMEs: ZONCU, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Cell Physiology;Cells;Cellular Membrane;Cholesterol;Communication;Complex;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Dedications;detection of nutrient;Disease;driving force;Endoplasmic Reticulum;FRAP1 gene;Functional disorder;Goals;Growth;Growth Factor;Health;Homeostasis;human disease;Lipids;Lysosomes;Malignant Neoplasms;Measures;Mediating;Membrane;Metabolic;Metabolic Diseases;Molecular;Neimann-Pick's Disease Type C;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nutrient;Nutrient availability;Organelles;Organism;Oxygen;Pathogenicity;Pathway interactions;Phosphotransferases;Physiological;programs;Proliferating;Protein Kinase;recruit;Regulation;response;Role;sensor;Signal Pathway;Signal Transduction;Site;Sterols;Surface;Time

PROJECT_TITLE: Molecular Mechanisms of Organelle-based Metabolic Signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE. This proposal seeks to evaluate the risks and benefits of deprescribing versus continuing bisphosphonates in older nursing home residents with Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD). This study will evaluate the qualitative perceptions of providers and caregivers, clinical outcomes, and healthcare- related costs to determine whether deprescribing bisphosphonates is a safe and reasonable strategy to reduce the medication burden for certain individuals in this population. The results from this study will contribute to the development of recommendations for the management of fracture prevention in older nursing home residents with AD/ADRD, a population not addressed in current guidelines

PI_NAMEs: NIZNIK, JOSHUA DAVID (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adult;Adverse effects;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Benefits and Risks;bisphosphonate;bone turnover;Caregivers;Caring;Clinical;clinical heterogeneity;Clinical Trials;Communities;Complex;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;cost-effectiveness ratio;Data;Decision Making;Decision Modeling;Deglutition Disorders;Dementia;Development;Diagnosis;disorder prevention;Elderly;end of life;Enrollment;Esophagitis;Exclusion;Family;Family Caregiver;Fracture;fracture risk;Future;gastrointestinal;Goals;Guidelines;health care service utilization;Health Services;Healthcare;human old age (65+);Impaired cognition;improved;incremental cost-effectiveness;Individual;informal caregiver;Intervention;Interview;Knowledge;Life Expectancy;Measures;Medical;Medicare;Medicare claim;Methods;Nursing Homes;Observational Study;older adult;osteoporosis with pathological fracture;Outcome;patient oriented;Perception;Pharmaceutical Preparations;Pharmacists;Polypharmacy;Population;Positioning Attribute;prevent;Prevention;Preventive;Principal Investigator;programs;Provider;Qualitative Research;Quality of life;Quality-Adjusted Life Years;Randomized;Recommendation;Research;Research Methodology;Research Personnel;residence;Sampling;Severities;side effect;skills;Structure;Subgroup;Techniques;Time;Training;Uncertainty

PROJECT_TITLE: Deprescribing Bisphosphonates in Older Nursing Home Residents with Dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Every year, 0.4-1.9% of individuals with mitral valve prolapse (MVP) will develop sudden cardiac death or arrest. In this application we propose to better identify those at risk by using cardiac magnetic resonance and echocardiography-based artificial intelligence, with the long-term goal of selecting those that may benefit most from a defibrillator. .

PI_NAMEs: DELLING, FRANCESCA N (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Arrhythmia;Artificial Intelligence;Autopsy;California;Cardiac;cardiovascular risk factor;Clinical;Clinical Markers;Complex;convolutional neural network;coronary fibrosis;cost;Data;Databases;Death Rate;Defibrillators;Development;Diffuse;Echocardiography;extracellular;Fibrosis;Future;Gadolinium;Goals;Heart Arrest;hemodynamics;High Prevalence;high risk;Holter Electrocardiography;Hybrids;Image;Image Enhancement;Implantable Defibrillators;improved;Individual;Left;Link;Machine Learning;machine learning algorithm;Magnetic Resonance;Maps;Mission;Mitral Valve Insufficiency;Mitral Valve Prolapse;mortality;Myocardial;neural network architecture;novel;Outcome;Patients;Phenotype;Population;predictive tools;Prevalence;Primary Prevention;prognostic significance;prospective;recurrent neural network;Registries;Retrospective Studies;Risk;risk prediction;risk prediction model;risk stratification;Role;Sampling;San Francisco;Screening procedure;secondary analysis;stem;sudden cardiac death;Survivors;Testing;tool;Training;Uncertainty;United States National Institutes of Health;Universities;Validation;Ventricular;Ventricular Tachycardia

PROJECT_TITLE: Prospective sudden cardiac death risk stratification using CMR and echocardiography machine learning in mitral valve prolapse

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hepatic stellate cell plasticity and maladaptive fibrogenic memory in chronic liver disease Liver fibrosis associated with chronic liver injury is a strong predictor of patient mortality thus an ideal therapeutic target for chronic liver disease patients. With acute injury, hepatic stellate cells activate to repair tissue damage and then return to quiescence, but with repeated injury, these cells hyperactivate to produce exuberant extracellular matrix that make up liver fibrosis. In this proposal, we will investigate the molecular changes that take place in hepatic stellate cells that drive their maladaptive behavior switch with repeated injury, which may shed light on novel antifibrotic strategies.

PI_NAMEs: WANG, SHUANG  (contact)

PROJECT_TERMS: Acute;acute liver injury;Adult;Affect;Animal Model;antifibrotic treatment;ATAC-seq;Attenuated;Automobile Driving;Behavior;Cell Nucleus;Cells;Cellular biology;Chromatin;chronic liver disease;chronic liver injury;Cicatrix;Cirrhosis;Data;Development;DNA;DNA Methylation;DNA methylation profiling;Drug Targeting;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Exposure to;Extracellular Matrix;Fibrosis;Future;Gene Expression;gene regulatory network;Genes;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Hematopoietic System;Hepatic;Hepatic Stellate Cell;Hepatocyte;Histologic;histone modification;Homeostasis;Human;Hyperactivity;in vivo;Inflammatory Response;injured;Injury;injury and repair;innovation;insight;knock-down;Knock-out;Liver;Liver diseases;Liver Fibrosis;liver injury;LoxP-flanked allele;maladaptive behavior;Measures;Mediating;member;Memory;methylation pattern;methylome;Modeling;Molecular;mortality;mouse model;Mus;nonalcoholic steatohepatitis;novel;Nucleic Acid Regulatory Sequences;Organ;Paper;Partial Hepatectomy;Pathway Analysis;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Proliferating;promoter;Regulatory Element;Research;response;response to injury;single cell technology;single nucleus RNA-sequencing;Skin;Skin injury;stellate cell;stem cells;Technology;Testing;Therapeutic;therapeutic target;tissue injury;tissue repair;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Viral;Wild Type Mouse;Work;WT1 gene;XCL1 gene


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Spatially Responsive Mass Vaccination Campaigns for Urban Rabies NARRATIVE Mass vaccination campaigns can prevent and control epidemics of infectious diseases among humans and animals. However, many campaigns leave spatial 'pockets' of under-vaccinated individuals. In this study, we propose to use a mass canine rabies vaccination campaign to field test computational approaches to increase vaccination equity and coverage, and use implementation science to assess the acceptability, scalability, and transferability of our new vaccination strategies.

PI_NAMEs: CASTILLO NEYRA, RICARDO  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Acceleration;Acute;Adoption;Affect;Algorithms;Animals;Area;Canis familiaris;Cities;Cluster randomized trial;Communicable Diseases;Complex;COVID-19 vaccination;Data;design;Disease;effectiveness/implementation hybrid;Ensure;Environment;Epidemic;epidemic response;Epidemiology;Equity;Evaluation;evaluation/testing;Exclusion;field study;geographic disparity;Geography;Goals;Health;health care availability;Health Services;Health system;Heterogeneity;Hour;Human;Immunization;Immunization Programs;implementation science;Improve Access;improved;Inequity;Infrastructure;intervention refinement;Interview;Laboratories;Latin America;Location;Maintenance;Mass Vaccinations;Mentored Research Scientist Development Award;Methods;Modeling;Modernization;pathogen;Peru;Play;Population;prevent;programs;Queuing Theory;Rabies;Rabies Vaccines;Research;Resources;Role;Running;Scheme;Services;Site;Spatial Behavior;Supplementation;Sustainable Development;Testing;theories;Time;Underserved Population;Update;Vaccinated;Vaccination;vaccination strategy;vaccine delivery;Vaccinee;Vaccines;Wait Time;Work;Zoonoses

PROJECT_TITLE: Spatially responsive mass vaccination strategies for urban rabies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Opioid use disorders (OUDs) are complex psychiatric conditions in which use of opioids followed by periods of withdrawal/abstinence are thought to engender both tolerance and physical dependence, leading to excessive opioid consumption despite aversive consequences (loss of job/family/home). The estimate of the total impact of the opioid crisis to society reaches over $500 billion, representing approximately 2.8% of the US gross domestic product. The aim of this proposal is to discover how opioids change neuronal circuits, and how these changes may affect behavior, and the data collected from these studies will hopefully allow us to ascertain new targets for behavioral and pharmacotherapy (medicine) treatments to alleviate OUDs.

PI_NAMEs: MCELLIGOTT, ZOE ANASTASIA (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Accidents;Acute;addiction;Address;Affect;Affective;AMPA Receptors;Amygdaloid structure;Animals;antagonist;Anxiety;anxiety-like behavior;Behavior;Behavior Therapy;Behavioral;Brain;Brain region;Calcium;Cell Nucleus;Cessation of life;Chronic;Chronic stress;Cognitive;comorbidity;Complex;Control Groups;cost;Coupled;Data;Disease;Economic Burden;Electrophysiology (science);Emotional;Exhibits;experience;Family;Frequencies;Functional disorder;genetic approach;Glutamates;Grant;Home;Homeostasis;improved;indexing;Job loss;Kinetics;Label;Measures;Mediating;Medicine;Modeling;Monitor;Morphine;mu opioid receptors;Mus;Naloxone;Negative Reinforcer;nerve supply;neural circuit;neuroadaptation;Neurobiology;neuronal circuitry;Neurons;Neurotransmitters;noradrenergic;Norepinephrine;Opioid;opioid abuse;Opioid agonist;opioid epidemic;opioid exposure;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Output;Overdose;overexpression;Periodicity;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physical Dependence;Physiological;Physiology;Population Projection;postsynaptic;presynaptic;prevent;Rattus;receptor;Regulation;Relapse;response;Rewards;Role;Scanning;sex;Sex Differences;sexual dimorphism;Signal Transduction;Sleep;sleep behavior;Sleep disturbances;Societies;Stress;Structure of terminal stria nuclei of preoptic region;Substance Withdrawal Syndrome;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;transmission process;United States;uptake;Virus;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Noradrenergic Plasticity in Opioid Withdrawal

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE DNA damage induces expression of non-pituitary colon GH, which, in turn, attenuates DNA repair pathways, yet accumulated epithelial DNA damage may enable an aging milieu favoring tissue degeneration, cancer, and metabolic dysfunction. We will use induced pluripotent stem-cell derived human colon organoids, normal human colon cells, and genetically altered mouse models to test the hypothesis that induction of local epithelial GH suppresses DNA damage response, reinforcing DNA damage. We propose a novel hypothesis whereby local epithelial non-pituitary GH is an adverse determinant for DNA damage accumulation and acts as an epithelial aging marker.

PI_NAMEs: MELMED, SHLOMO  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;aged;Aging;aging biomarker;aging population;antagonist;Apoptosis;Attenuated;autocrine;Cell Aging;Cell Proliferation;Cells;chemotherapy;Chromosomal Instability;Coculture Techniques;cohort;Colon;colon growth;CRISPR/Cas technology;Data;design;Devices;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;DNA-PKcs;ds-DNA;Endocrine;Epithelial Cells;Epithelium;experimental study;Fibroblasts;Gene Expression;Genes;genomic profiles;Genomics;Growth;Growth Hormone Receptor;Homeostasis;homologous recombination;hormonal signals;hormone regulation;Human;Hypophysectomy;IGF1 gene;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;innovation;Intestines;JAK2 gene;Knockout Mice;Left;Lentivirus;Malignant Neoplasms;Mediating;Metabolic;Metabolic dysfunction;Metformin;Microfluidic Microchips;Modeling;mouse model;Mus;Mutation;Neoplasms;Nonhomologous DNA End Joining;novel;Oncogenes;Organoids;overexpression;paracrine;Pathway interactions;Patients;pegvisomant;Peripheral;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation Inhibition;Proliferating;Publishing;Rattus;receptor;Receptor Signaling;Regulation;repaired;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Transduction;single-cell RNA sequencing;Somatotropin;Somatropin;Specimen;stressor;Telomere Shortening;Testing;tissue degeneration;Tissue-Specific Gene Expression;Tissues;TP53 gene;transcriptome sequencing;Transgenic Mice;Transgenic Model;Ultraviolet Rays

PROJECT_TITLE: Mechanisms for GH action on epithelial cells

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Recently, we reported our discovery of mitochondria-rich extracellular vesicles (M-EVs), which are produced by the iPSC-derived cardiomyocytes (iCMs). We identified functional mitochondria and cluster of enriched proteins associated with mitochondrial biogenesis (PC) in the M-EVs. These M-EVs and their payload may provide an effective and novel therapeutic to restore the bioenergetic imbalance of the injured myocardium in heart failure patients.

PI_NAMEs: YANG, PHILLIP CHUNG-MING (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adrenergic beta-Antagonists;Aldosterone;Angiotensins;antagonist;Bioenergetics;Biogenesis;Cardiac;Cardiac Myocytes;cell injury;Cell Physiology;Chronic;Citric Acid Cycle;Clinical;Congestive Heart Failure;Data;Diagnosis;Dilated Cardiomyopathy;Electron Transport;Energy Metabolism;Energy Supply;Energy-Generating Resources;Engraftment;Equilibrium;Exhibits;extracellular vesicles;fatty acid metabolism;functional restoration;Future;Generations;Genome;genomic profiles;Glycolysis;Heart;Heart failure;Hospitalization;Hypertrophic Cardiomyopathy;Hypoxia;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Injections;injured;Injury;injury and repair;innovation;Innovative Therapy;ischemic cardiomyopathy;loss of function;Mediating;Messenger RNA;Metabolic;microvesicles;Mitochondria;Mitochondrial DNA;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial dysfunction;myocardial injury;Myocardium;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Oxidative Phosphorylation;paracrine;Pathogenesis;Patients;pharmacologic;Ploidies;PPAR gamma;preclinical study;Production;protective effect;protein expression;Proteins;Proteome;Proteomics;Regimen;Renin;Reporting;Research Personnel;Respiratory physiology;restoration;Role;Shapes;standard of care;Structural defect;targeted treatment;Teratoma;Therapeutic;Tissues;Transgenic Organisms;treatment strategy;Ventricular Arrhythmia;Work;Workload

PROJECT_TITLE: Mitochondria-rich microvesicles for restoration of intracellular bioenergetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE Tau self-assembly into fibrils that form cellular inclusions is foundational to the pathology of Alzheimer’s Disease (AD) and other tauopathies such as Cortico Basal Degeneration (CBD). However, the factors that initiate the folding and aggregation of tau are unknown. A team of cell biologist, physical chemist and a theoretical biophysicist propose to work together to determine the pathway from normal tau to pathological tau, to replicate tauopathy disease-phenotypic tau fibrils and to discover the cellular factors that initiate the pathological pathway of tau misfolding, aggregation and propagation.

PI_NAMEs: HAN, SONGI ;KOSIK, KENNETH STEPHEN (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;aggregation pathway;Alzheimer's Disease;Alzheimer's disease pathology;Antibodies;Autopsy;Binding;Biological;Brain;brain tissue;Bypass;Cell Line;Cells;Cellular biology;Chemistry;clinical phenotype;cofactor;Competence;computerized tools;corticobasal degeneration;Cromolyn Sodium;cryogenics;Cytoplasm;Dedications;Detection;Development;Diagnosis;Diagnostic;diagnostic value;Disease;disease phenotype;Disease Progression;Electrons;Endosomes;Environment;Event;experimental study;Feedback;Fostering;Generations;Goals;Hand;Heparin;Human;Hydrophobic Surfaces;Hydrophobicity;In Vitro;Inclusion Bodies;Induced pluripotent stem cell derived human neuron;innovation;Investments;Knowledge;Laboratories;Learning;Ligands;Light;Lipids;Liquid substance;Location;Mediating;Modeling;Molecular;Morphology;Mus;Mutation;Neurofibrillary Tangles;notch protein;Organoids;Pathologic;Pathology;Pathway interactions;Patients;Peptide Initiation Factors;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiologic pulse;Play;Population;Porosity;Positron-Emission Tomography;Progressive Supranuclear Palsy;Property;protein folding;Proxy;receptor;Research;screening;self assembly;Shapes;small molecule;structural biology;Structure;success;System;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Transmission Electron Microscopy;Travel;uptake;Work

PROJECT_TITLE: Drivers of Pathological Tau Aggregation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Recent identification of a series of compounds which act to induce neuronal TFEB, the master transcriptional regulator of lysosomal autophagy, lead us to the surprising discovery that our lead compound `C1' acts as a “reverse agonist” of the nuclear hormone receptor DAF-12/FXR. Although FXR is best known for its ability to act in the liver and gut to maintain lipid homeostasis, it has recently been shown to be present in brain neurons although its role in here is currently unexplored. In this current application, we propose to test the hypothesis that neuronal FXR mechanistically acts to modulate levels of TFEB-mediated autophagy and as such constitutes a novel target for the treatment of age-related neurodegenerative diseases including Alzheimer's disease (AD).

PI_NAMEs: ANDERSEN, JULIE KAY (contact);LITHGOW, GORDON J

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related;age related neurodegeneration;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;antagonist;Autophagocytosis;Biochemical;Biogenesis;Brain;Brain region;brain tissue;Caenorhabditis elegans;Cell Line;Characteristics;Chemicals;Collaborations;Dementia;Development;Disease;disease model;Excision;experimental study;Functional disorder;Genetic;Genetic Transcription;Homeostasis;Human;human disease;human old age (65+);Impaired cognition;In Vitro;in vivo;in vivo Model;Induced Neurons;Induced pluripotent stem cell derived human neuron;Lead;Lipids;Liver;Lysosomes;Mediating;Mitochondria;Modeling;mouse model;Mus;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;Neurons;neuropathology;neuroprotection;neurotoxic;novel;Nuclear Hormone Receptors;Parkinson Disease;Pathologic;Pathology;prevent;Process;protein aggregation;Proteins;proteostasis;proteotoxicity;Role;Series;Signal Transduction;Sirolimus;Synapses;tau Proteins;Tauopathies;Testing;therapeutic target;transcription factor

PROJECT_TITLE: Neuronal FXR as a potential therapeutic target for Alzheimer's disease


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Continuous renal replacement therapy is the preferred dialysis treatment for critically ill patients with acute kidney injury, yet mortality is high. Presently, there are no accurate approaches for predicting survival or kidney recovery in these patients. We propose to deliver innovative deep learning approaches to predict these outcomes at actionable timepoints, and identify patient sub-phenotypes for model interpretation and clinical utility testing.

PI_NAMEs: NADKARNI, GIRISH NITIN;NEYRA, JAVIER A. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: acute care;Acute Renal Failure with Renal Papillary Necrosis;Affect;Algorithms;Artificial Intelligence;Awareness;Biometry;Blood Vessels;Caring;Catheters;Classification;Clinic;Clinical;Clinical Data;clinical decision support;clinical development;Clinical Research;Clinical Trials;clinically relevant;computing resources;Critical Illness;Data;data resource;Data Set;Decision Making;deep learning;deep learning model;density;Development;Dialysis procedure;Dose;Electronic Health Record;Excision;Exclusion;experience;Fluid Therapy;Future;Goals;hemodynamics;Hour;improved;improved outcome;innovation;Institution;Intensive Care Units;Intervention;Kidney;Liquid substance;Logistic Regressions;Measurement;Measures;Modality;model development;Modeling;modifiable risk;Modification;Monitor;mortality;multimodal data;multimodality;novel;Outcome;outcome prediction;Patient Admission;Patients;personalized intervention;Phenotype;Population;precision medicine;predict clinical outcome;predictive modeling;Prognosis;Publishing;Recovery;Registries;Renal Replacement Therapy;Reproducibility;Research;Resolution;Risk;Risk Factors;risk prediction;risk prediction model;Series;solute;survival prediction;Survivors;Testing;Therapeutic Intervention;Time;tool;Validation;Vulnerable Populations

PROJECT_TITLE: Artificial Intelligence to Predict Outcomes in Patients with Acute Kidney Injury on Continuous Renal Replacement Therapy

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Our objective is to develop general principles for engineering proteases that can control signaling in cells. In accomplishing this objective we will develop tools for controlling signaling in a cell, and ultimately create avenues to advanced therapeutics.

PI_NAMEs: ORBAN, JOHN  (contact);TOTH, ERIC A

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Adopted;Allosteric Site;Biochemical;Biological Models;Biophysics;Cancer cell line;Cancer Model;Catalysis;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular biology;Chemicals;cofactor;Complex;controlled release;design;Distal;Engineering;Enzymatic Biochemistry;Enzyme Precursors;experimental study;Generations;Goals;Homologous Gene;Human;Imidazole;improved;insight;interdisciplinary approach;Kinetics;Knowledge;KRAS2 gene;Libraries;Malignant neoplasm of urinary bladder;Methods;Modeling;Molecular;Molecular Conformation;Multidimensional NMR Techniques;mutant;Mutation;Nitrites;Oncogenic;pancreatic cancer cells;Peptide Hydrolases;Peptides;Phage Display;Protein Engineering;Protein Isoforms;Proteins;RAS genes;Reaction;Recommendation;Rhabdomyosarcoma;Roentgen Rays;Signal Transduction;Signaling Protein;Site;Specificity;Structure;System;Testing;Text;Therapeutic;tool;Variant;X-Ray Crystallography

PROJECT_TITLE: Engineering protein-specific proteases: targeting signaling proteins


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative-Relevance to Public Health Cancer arises as a result of the accumulation of genetic alterations. We propose to develop a novel strategy of combining nanobomb-mediated RNA interference that precisely targets the genomic defects in triple negative breast cancer (TNBC) with clinically used chemotherapy drug for combating the therapeutic resistance of TNBC, and to understand the therapeutic and resistant mechanisms. This project will have a significant impact on improving cancer treatment to reduce the mortality of patients with cancer in general and TNBC in particular.

PI_NAMEs: HE, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;American;Animals;anti-cancer;Biological Availability;Biomimetics;Blood;Blood Circulation;Blood Proteins;Body Weight;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;cancer cell;cancer drug resistance;Cancer Etiology;cancer therapy;cancer type;Catalytic Domain;CD44 gene;Cell division;Cell Survival;Cells;cellular transduction;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;Colorectal Cancer;Complex;CRISPR/Cas technology;cytokine;Cytosol;Data;Defect;Development;Disease;drug relapse;Drug resistance;Encapsulated;Endothelial Cells;Essential Genes;experience;Foundations;fucoidan;Gene Delivery;Gene Dosage;Genetic Transcription;Genomics;Growth;Human;human model;Hyaluronic Acid;hydrophilicity;Hydrophobicity;Immune response;improved;In Vitro;in vivo;Lasers;Ligands;liposomal delivery;liver function;Lysosomes;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammalian Cell;Mediating;Messenger RNA;Metformin;Microfluidics;MicroRNAs;Microtubule Stabilization;Microtubules;miniaturize;mortality;mouse model;Mutation;nanobomb;nanoparticle;Nanotechnology;Nature;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutics;overexpression;P-Selectin;Paclitaxel;Patients;Permeability;Pharmaceutical Preparations;POLR2A gene;Probability;Proliferating;Public Health;Publishing;Resistance;resistance mechanism;RNA;RNA delivery;RNA Interference;RNA Polymerase II;RNA Stability;Sequence Deletion;Signal Transduction;siRNA delivery;small hairpin RNA;Small Interfering RNA;stem cells;stem-like cell;systemic toxicity;targeted treatment;taxane;Testing;Therapeutic;therapeutic RNA;therapy resistant;three dimensional cell culture;TP53 gene;Translating;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor initiation;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenic;uptake;Variant;virtual;Woman;Work;Xenograft procedure

PROJECT_TITLE: Nanotechnology for targeted therapy and fundamental understanding oftherapeutic resistance in triple negative breast cancer


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Dietary Supplements;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative We have discovered all-trans retinoic acid (ATRA), a metabolite of Vitamin A and master gene-switch that controls many genes that are important to heart function, declines in patients with one type of human heart failure (HF) as well as an animal model. We want to understand three things about ATRA and HF: 1. What enzymes metabolize Vitamin A to ATRA in heart muscle cells? 2. How does low ATRA alter heart function? 3. How pervasive is low ATRA across different types HF?

PI_NAMEs: FOSTER, D BRIAN (contact);KANE, MAUREEN A

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adult;All-Trans-Retinol;Anabolism;Animal Model;Binding;Biological Assay;biosignature;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Catabolism;cellular engineering;Cellular Retinol Binding Protein;ChIP-seq;Circulation;Clinical;cohort;Collaborations;Coronary Arteriosclerosis;Coronary heart disease;Data;Drops;Echocardiography;EFRAC;Elements;Endoplasmic Reticulum;Enzyme Interaction;Enzymes;Epigenetic Process;Etiology;Evaluation;Exhibits;Face;Family member;Fluorescence Microscopy;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Half-Life;Heart;heart cell;Heart failure;heart failure with reduced ejection fraction;heart function;hemodynamics;Homeostasis;Hormones;Human;Human Engineering;human stem cell-derived;Hypertrophic Cardiomyopathy;Image;Impairment;in vitro activity;ischemic cardiomyopathy;Kinetics;knock-down;Knock-out;Knockout Mice;Knowledge;Label;mass spectrometric imaging;Mass Spectrum Analysis;medical schools;Messenger RNA;Metabolic;Metabolism;MicroRNAs;Mitochondria;Mixed Function Oxygenases;Monitor;mouse model;Mus;Myocardial Ischemia;Myofibrils;novel;Nuclear;Organ;Outer Mitochondrial Membrane;overexpression;Oxidoreductase;Patients;Physiological;pleiotropism;Post-Translational Protein Processing;postnatal;Pre-Clinical Model;preservation;pressure;prevent;Primary idiopathic dilated cardiomyopathy;Production;programs;promoter;Proteins;Proteomics;Reaction;Relaxation;Reporter;Reporting;response;Retinaldehyde;Retinoic Acid Receptor;Retinoids;Retinol Binding Proteins;Retinol dehydrogenase;Retinol Metabolism Pathway;Role;Signal Transduction;Site;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Techniques;Technology;Testing;Therapeutic;Tissues;transcription factor;transcriptome;translational potential;Tretinoin;ultra high resolution;Vitamin A

PROJECT_TITLE: Retinoid Metabolism in the Adult Heart and Heart Failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Frontotemporal Dementia (FTD);Genetics;Human Fetal Tissue;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: Our studies will investigate the cellular mechanisms by which APP overexpression observed in trisomy of chromosome 21 (Ts21) that causes Down Syndrome (DS) leads to increased transmission of tauopathy and neurodegeneration. To study tau transmission and its impact on neuronal circuitry, we will use a novel time lapse, imaging platform, four-dimensional robotic microscopy (4DRM) to longitudinally track functional properties of individual neurons in 4D in human brain organoids, primary human brain slices, and live zebrafish. With 4DRM, we will define how APP overexpression leads to hyperexcitability of neurons, to contribute to an increased rate of transmission of tau pathology, which will lead to better strategies to block the spread of neuropathology to slow the progression of early onset dementia found in DS.

PI_NAMEs: FINKBEINER, STEVEN M (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein Precursor;Animal Model;Animals;Behavioral;Biological Assay;Brain;brain circuitry;Cells;Chromosome 21;Coculture Techniques;Cognitive deficits;Complement;demented;Dementia;Down's Syndrome;driving force;early onset;Early Onset Alzheimer Disease;epileptiform;fetal;Fishes;Foundations;Four-dimensional;Frontotemporal Dementia;General Population;Genetic Polymorphism;Goals;hazard;Hippocampus;Human;Human Amyloid Precursor Protein;human induced pluripotent stem cells;Hyperactivity;hyperphosphorylated tau;imaging platform;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;insight;interdisciplinary approach;knock-down;Label;Larva;Long-Term Potentiation;MAPT gene;Mediating;Methods;Modeling;Molecular;Monitor;Nerve Degeneration;Nervous System;network dysfunction;neural;neural circuit;Neurofibrillary Tangles;neuron loss;neuronal circuitry;Neuronal Dysfunction;neuronal survival;Neurons;neuropathology;novel;Optics;Organoids;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;Physiologic pulse;Physiological;Prevalence;Process;progressive neurodegeneration;Property;Protein Overexpression;Risk;robotic microscopy;Rodent;Role;Seizures;Senile Plaques;Slice;Sorting;Synapses;System;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Technology;Testing;Time;Tissues;transcriptome sequencing;Transgenic Organisms;transmission process;Transplantation;Trisomy;Zebrafish

PROJECT_TITLE: Cell and Network Disruptions and Associated Pathogenenesis in Tauopathy and Down Syndrome

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: HEITZEG, MARY M (contact);SRIPADA, CHANDRA SEKHAR

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Michigan;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Over 40% of adults are obese in the US. Pharmaceutical options for treating obesity have been very limited and not efficacious. Leveraging comprehensive genetic resources for adiposity, psychiatric traits and addictive risk behaviors and rich phenome information across large-scale biobanks, we propose to integrate multi-layers of omics with innovative analytic methodologies to identify novel obesity drug targets that are both efficacious and safe to fill in the critical unmet need of pharmaceutical therapy of obesity.

PI_NAMEs: LU, YINGCHANG  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Action Potentials;adult obesity;Adverse effects;Agonist;Amygdaloid structure;analog;antagonist;Anxiety;bariatric surgery;Behavior;Behavioral;biobank;Bipolar Disorder;Body fat;Body mass index;Body Weight decreased;Brain;Brain Stem;Candidate Disease Gene;cardiometabolism;Central Nervous System;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;comorbidity;Data;Desire for food;differentiation protocol;Digestion;Dopamine Antagonists;drinking;drug action;Drug Targeting;Drug usage;Eating;effective therapy;Electronic Health Record;Endocannabinoids;Energy Intake;Esthesia;exome;exome sequencing;FDA approved;Feeling suicidal;functional genomics;Genes;Genetic;genetic resource;genetic signature;Genetic study;genome wide association study;GLP-I receptor;Health system;human induced pluripotent stem cells;Hypothalamic structure;In Vitro;Individual;Induced pluripotent stem cell derived neurons;innovation;insulin signaling;Investigation;islet amyloid polypeptide;Length;LEPR gene;Leptin;Limbic System;Link;lipid biosynthesis;liraglutide;Major Depressive Disorder;Mendelian randomization;Mental Depression;Metabolism;Methodology;Molecular;Moods;Mutation;neural circuit;Neurites;Neurons;Neuropeptides;new therapeutic target;novel;Nucleus Accumbens;Obesity;Obesity Epidemic;obesity risk;obesity treatment;Obsessive-Compulsive Disorder;Participant;Pathogenicity;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;phenome;Physical activity;Plasma;pluripotent stem cell differentiation;Prevention;Production;programs;Proteins;Proteome;receptor;Reporting;Resources;Rewards;rimonabant;Risk Behaviors;Safety;Satiation;screening;Smoking;Structure of nucleus infundibularis hypothalami;substance use;success;Therapeutic;therapeutic target;trait;Trans-Omics for Precision Medicine;Transcript;transcriptome;Veterans;virtual;Waist-Hip Ratio;Work

PROJECT_TITLE: Virtual systemic identification of drug targets of obesity candidate genes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Obesity;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Obesity is associated with a higher risk of developing pancreatic cancer and worse disease prognosis. Although elevated levels of insulin and insulin-like growth factors contribute to tumor progression and chemotherapeutic resistance, the underlying mechanisms are poorly understood. The metabolic enzyme ATP- citrate lyase (ACLY) is activated in response to insulin signaling and regulates histone acetylation levels in cancer cells, and the proposed study will test the hypothesis that metabolic alterations mediate epigenetic and transcriptional changes to promote tumor progression and may represent targetable vulnerabilities.

PI_NAMEs: WELLEN, KATHRYN ELAINE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetate-CoA Ligase;Acetyl Coenzyme A;Acetylation;advanced disease;AKT inhibition;Anabolism;ATP Citrate (pro-S)-Lyase;Automobile Driving;barrier to care;cancer cell;Cell Proliferation;Cell Survival;cell type;Cells;Chemoresistance;chemotherapy;Circulation;Compensation;Data;Development;Diagnosis;Disease;disease prognosis;Enzymes;Epigenetic Process;epigenome;Excision;Exposure to;flexibility;Gene Expression;Gene Expression Regulation;Genetic;Genetic Models;Genetic Transcription;Health Benefit;high risk;Histone Acetylation;Human;Hyperinsulinism;Impairment;improved;in vivo;Incidence;Individual;Insulin;insulin mediators;insulin signaling;KRAS2 gene;Link;Lysine;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammalian Cell;Mediating;Metabolic;Metabolism;metabolome;mevalonate;Modeling;mouse model;Mus;mutant;Neoplasm Metastasis;new therapeutic target;nutrition;Nutritional;Obesity;Operative Surgical Procedures;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic tumorigenesis;Pathway interactions;Patients;pharmacologic;Phosphorylation;Play;Populations at Risk;prevent;Prevention strategy;Primary Neoplasm;Process;Production;Prognosis;Proliferating;Proto-Oncogene Proteins c-akt;Public Health;Reading;Recommendation;Recurrent tumor;Regulation;Resected;response;Risk;Role;Signal Transduction;Somatomedins;Supporting Cell;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Transcription Alteration;Treatment Efficacy;Treatment outcome;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Unresectable;Work

PROJECT_TITLE: Role of acetyl-CoA in linking cancer cell metabolism and epigenetics

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Understanding how cells store and mobilize lipids is an urgent scientific and therapeutic goal. This project addresses the molecular and biophysical mechanisms by which the protein ABHD5 regulates the mobilization and storage of lipids in cells. Understanding how ABHD5 can be targeted by synthetic compounds could lead to new therapies for diabetes, obesity, and cancer.

PI_NAMEs: GRANNEMAN, JAMES G (contact);KELLY, CHRISTOPHER V

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;Binding;Biochemical Pathway;biochemical tools;Biological;Biological Models;Biophysical Process;biophysical properties;biophysical techniques;Biophysics;Cells;Chemicals;Complex;Cytosol;Data;design;Diabetes Mellitus;diabetes mellitus therapy;Enzymes;Equilibrium;Esterified Fatty Acids;Event;Fatty acid glycerol esters;fatty acid supplementation;Fatty Acids;fatty liver disease;Fostering;Funding;Futile Cycling;Genetic;Goals;Grant;Health;Heart;Homo;Inflammation;Inflammatory;insight;Ligand Binding;Ligands;Lipase;lipid metabolism;Lipid Mobilization;Lipids;Lipolysis;Liver;Malignant Neoplasms;Measures;Membrane;membrane model;Metabolic;Metabolic Diseases;Metabolism;Methods;Mixed Function Oxygenases;Modeling;Molecular;Molecular Conformation;monolayer;Muscle;mutant;novel;novel therapeutic intervention;novel therapeutics;Obesity;oleoyl-coenzyme A;paralogous gene;Pathway interactions;perilipin;pharmacologic;Phospholipase;Phospholipids;Physiology;Play;protein complex;protein transport;Proteins;receptor;recruit;Regulation;Repression;Resolution;Role;Shapes;Signal Transduction;Site;skin barrier;Structure;subcellular targeting;Surface;Surface Tension;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thermogenesis;Tissues;tool;trafficking;Transducers;Triglycerides;tumor progression;Validation

PROJECT_TITLE: Analysis of Lipolytic Trafficking in Adipocytes.

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative This project investigates cellular and molecular mechanisms of fibrolamellar hepatocellular carcinoma (FLC). The project is translational and examines if the inhibition of b-catenin in patient-derived FLC spheroid cells and animal models of FLC will repress tumor development. The project will generate a background for clinical trials with FLC patients which will be based on the inhibition of the b-catenin.

PI_NAMEs: SHIN, SOONA ;TIMCHENKO, NIKOLAI A. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Adolescent;Anabolism;Animal Model;anti-cancer;beta catenin;Binding;Binding Sites;Biological Models;biological systems;Cell model;Cells;Child;Chimeric Proteins;Chromosome 19;Cirrhosis;Clinical;Clinical Trials;cohort;Collagen;Complex;Data;design;Development;Disease;effective therapy;Enzymes;Event;Exhibits;Fibrolamellar Hepatocellular Carcinoma;Fibrosis;Gene Expression;Genes;Genomic Segment;Guide RNA;Human Genome;Impairment;inhibitor;Injections;Investigation;Liver;liver cancer model;Liver diseases;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Mediator;Medical;Metabolic;Metabolic Pathway;Metabolism;Metastatic Neoplasm to the Lung;Molecular;mouse model;Mus;Neurons;Oncogenes;Oncoproteins;Operative Surgical Procedures;Pathologic;Pathology;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Proliferating;promoter;Protein Kinase;Proteins;Recording of previous events;Relapse;Repression;Role;Sampling;spheroids;TCF7L2 gene;Testing;therapy development;Time;transcriptomics;Treatment Efficacy;tumor;urea cycle;Western Blotting;young adult

PROJECT_TITLE: The role of DNAJB1-PKAc-β-catenin axis in fibrolamellar HCC


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE There has been great interest in advancing HDL-targeted therapies to prevent and manage atherosclerosis. Over the past several years, we have developed a novel class of HDL modulators based on amphiphilic cyclic D,L-a-peptides, which reduce dyslipidemia and prevent the development of atherosclerosis in vivo. Building on these exciting findings, this project seeks to advance such molecular entities as mechanistically novel therapeutic agents for treating atherosclerosis.

PI_NAMEs: GHADIRI, M. REZA (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Abate;Acetyl Coenzyme A;Address;Adipocytes;Adverse effects;Amino Acids;amphiphilicity;analog;Animals;Antiatherogenic;Antiinflammatory Effect;Apolipoprotein A-I;Apolipoprotein E;Apolipoproteins;Atherosclerosis;Binding;Biological;Biological Assay;Biological Availability;Biology;Biophysics;Cells;Cholesterol;Clinic;Clinical Trials;Coenzyme A;combat;cost;Cyclic Peptides;Data;design;Development;Disease;disease model;Dose;Dyslipidemias;efficacy study;Evaluation;Family;Funding;Goals;Grant;gut microbiome;High Density Lipoproteins;High Pressure Liquid Chromatography;Human;human mortality;human tissue;improved;In Vitro;in vitro Assay;in vivo;inhibitor;interest;intraperitoneal;Knockout Mice;LDL Cholesterol Lipoproteins;Lead;lead optimization;Lipids;Lipolysis;Lipoproteins;Liver;Macrophage;Marketing;Mediating;Metabolic;Metabolism;mimetics;Molecular;Molecular Structure;mouse model;Mus;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Oral;Oral Administration;organic acid;particle;Peptide Nanotubes;Peptide Synthesis;Peptides;peptidomimetics;Periodicity;Peripheral;Peroxisome Proliferation;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Plasma;Population;pre-beta high-density lipoprotein;prevent;Prevention;Process;Production;programs;Proteins;reagent standard;receptor;Research;reverse cholesterol transport;Route;self assembly;Series;Serum;Side;stem;Structure;success;synthetic peptide;targeted treatment;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Toxicology;transcriptome sequencing;Trifluoroacetate;Triglycerides

PROJECT_TITLE: Managing Atherosclerosis by Modulating HDL Function

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: VANCOUVER

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: PROJECT NARRATIVE The purpose of this proposed cohort study is to investigate HIV-related disparities, evaluate the uptake and impact of the next generation of HIV treatment, and study the effects of coinfections, comorbidities and complications on HIV disease outcomes. This study will involve 1000 HIV-positive people who use illicit drugs in Vancouver, Canada.

PI_NAMEs: MILLOY, M-J  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Achievement;addiction;Address;Adherence;Agonist;AIDS prevention;antagonist;antiretroviral therapy;Area;Basic Science;Bioinformatics;Biological;Canada;Caring;Chronic;chronic pain;Clinical;clinical biomarkers;Clinical Data;clinical epidemiology;Clinical Management;co-infection;cohort;Cohort Studies;Communities;comorbidity;cost;cost effectiveness;Data;Development;Disease;Disease Outbreaks;Disease Outcome;Disease Progression;Disparity;disparity reduction;Drug usage;Drug user;economic determinant;Economic Factors;Economics;effective therapy;Environment;Epidemic;Epidemiology;Evaluation;Evolution;experience;Formulation;Funding;Generations;Genetic;Harm Reduction;Healthcare Systems;Hepatitis C;Hepatitis C co-infection;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV Seropositivity;HIV-1;HIV/AIDS;Homelessness;illicit drug use;Illicit Drugs;Immune System Diseases;Immunologics;Imprisonment;improved;Income;Individual;Inequality;Inflammation;Injectable;Injecting drug user;innovation;Intervention;Investigation;Life Expectancy;Link;Longitudinal Studies;Maintenance;marginalization;Measures;Medical;Medical Care Costs;Medicine;Methods;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multiple drug use;National Institute of Drug Abuse;next generation;non-opioid analgesic;novel;novel strategies;opioid use;opioid use disorder;Outcome;Pain;Pain management;participant interview;Pathogenesis;Pattern;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Plasma;Policies;Positioning Attribute;Premature aging syndrome;prescription opioid misuse;Primary Care;programs;Prospective cohort;Prospective, cohort study;Recording of previous events;Records;recruit;Regimen;Research;Research Priority;Resistance;RNA;Role;Severity of illness;Site;social;social determinants;social factors;Social Sciences;social stigma;socioeconomics;Specimen;stimulant use;stimulant use disorder;structural determinants;Study models;Therapeutic;Time;transmission process;treatment guidelines;Treatment outcome;United States;uptake;Viral Load result;virology;Work

PROJECT_TITLE: Impacts of universal access to HIV/AIDS care among HIV+ injection drug users


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Our understanding of HIV latency and persistence has been complicated by the small numbers of latently infected cells in vivo. This project develops highly sensitive assays to measure m6A RNA modifications in HIV RNA in patient samples and informative primary cell models for HIV latency to study the epitranscriptomic regulation of HIV transcription.

PI_NAMEs: KARN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: acute infection;Adenosine;Antibodies;Behavior;Biological Assay;Cell model;cell transformation;Cells;cellular imaging;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;design;DNA;emerging virus;Epigenetic Process;epitranscriptomics;Event;experience;experimental study;gene editing technology;Gene Expression;Genetic Transcription;Goals;histone demethylase;HIV;HIV Infections;HIV tat Protein;Immunoprecipitation;in vivo;Informatin;inhibitor;Interleukin-15;Jurkat Cells;Kinetics;knock-down;Knock-out;Laboratories;Maps;Measures;Meclofenamic Acid;Messenger RNA;Metabolic;Methylation;Modeling;Modification;mRNA Precursor;multidisciplinary;Mutagenesis;nanopore;Nature;next generation sequencing;Nuclear Export;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Play;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;protein expression;Proviruses;reactivation from latency;Reader;Regimen;Regulation;Resolution;response;RNA;RNA methylation;RNA Splicing;RNA Stability;Role;Sampling;Shock;single-cell RNA sequencing;Site;small hairpin RNA;synergism;System;T memory cell;T-Lymphocyte;Technology;Testing;Therapeutic;Transcript;transcriptome sequencing;Transportation;Up-Regulation;viral RNA;Virion;Virus;Virus Latency;Virus Replication;Visualization;Work

PROJECT_TITLE: The role of RNA m6A modification in the regulation of HIV latency and reactivation


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases;Regenerative Medicine

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Acetaminophen (APAP) overdose is the foremost cause of acute liver failure (ALF) in the United States and has very limited treatment options. Although, HGF receptor (MET) and EGF receptor (EGFR) are conventionally known to have similar roles in liver regeneration after partial hepatectomy, surprisingly our studies indicate that they have contrasting roles in the clinically- relevant model of APAP-induced ALF. Based on our unexpected findings, we will comprehensively investigate the uncharted roles of EGFR and MET in liver injury and the associated compensatory regeneration in APAP-induced ALF model, understand the underlying mechanisms and further, explore the clinical relevance to pave the way for novel therapeutics for ALF.

PI_NAMEs: BHUSHAN, BHARAT  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;Acetylcysteine;Acute Liver Failure;acute liver injury;Address;Analgesics;Antioxidants;Autophagocytosis;Biology;Canertinib;Cell Death Signaling Process;Cessation of life;Clinical;clinical effect;clinically relevant;clinically significant;Epidermal Growth Factor Receptor;Functional disorder;genetic approach;Glutathione;Growth Factor Receptors;Hepatocyte;Human;inhibitor;Injury;insight;Intervention;intervention effect;Knock-out;Ligands;Literature;Liver;liver cell proliferation;Liver Failure;liver inflammation;liver injury;Liver Regeneration;medical attention;MET gene;Mitochondria;Modeling;Mus;Natural regeneration;novel;novel therapeutics;Oxidation-Reduction;oxidative damage;Partial Hepatectomy;Patients;pharmacologic;Pharmacological Treatment;Play;Publishing;receptor;Receptor Activation;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;Recovery;regenerative;Regenerative response;Role;Severities;Signal Transduction;Source;Therapeutic;Time;Transforming Growth Factor alpha;United States;Work

PROJECT_TITLE: Diverging roles of EGFR and MET in acetaminophen-induced acute liver injury

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Mississippi is among the leaders in health disparities in cardiovascular diseases that disproportionately affect individuals from disadvantaged and underrepresented racial and ethnic populations. At the same time, Mississippi lags in the development of a robust pipeline of biomedical researchers that can address these important issues. This grant proposes to continue a successful summer research training and mentoring program in cardiovascular research for undergraduate students from disadvantaged and underrepresented racial and ethnic populations in Mississippi.

PI_NAMEs: TAYLOR, ERIN BASSFORD (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Affect;African American population;Area;Bachelor's Degree;Basic Science;Biomedical Research;Biophysics;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Career Choice;Centers of Research Excellence;clinical center;Clinical Investigator;Clinical Research;Clinical Sciences;Country;Data;Dental Schools;Development;Diabetes Mellitus;Disadvantaged;disadvantaged student;Disease;Disparity population;District of Columbia;Doctor of Philosophy;Education;Employment;Ensure;Environment;Ethnic Origin;Ethnic Population;experience;Extramural Activities;Faculty;feeding;Funding;Future;Goals;graduate school;graduate student;Grant;Health;health care disparity;health disparity;Healthcare;Heart Diseases;Hispanic Americans;Hypertension;improved;Individual;innovation;Institution;interest;Kidney;Kidney Diseases;Location;Medical center;medical schools;Mentors;Metabolic Diseases;Mission;Mississippi;mortality;multidisciplinary;Nephritis;Nephrosis;Participant;Physical therapy;Physician Assistants;Physiology;Population Sciences;Postdoctoral Fellow;programs;Puerto Rico;Race;racial population;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Schools;Science;Standardization;Stroke;Students;summer research;Testing;Time;Training;Training and Education;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Mississippi Diversity in Hypertension and Cardiorenal Research Program


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CORVALLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE - Overall The OSU EHS Core Center builds research and stakeholder engagement capacity to help understand what people are exposed to in their homes, at their work places and in their communities, and to discover what hazards these exposures may pose to their health. We aim to address the environmental health concerns of individuals, communities, industries, and regulators to better protect and improve human health.

PI_NAMEs: DEWITT, JAMIE  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Access to Information;Address;adverse outcome;Air;Anatomy;Animal Experiments;Area;Behavioral;Big Data;Biological;Biological Assay;biological research;Biomedical Research;Categories;Cell Culture Techniques;Chemical Exposure;Chemicals;Collaborations;Commerce;Communities;community engagement;Core Facility;cost;Country;Data;Data Science;data to knowledge;decision research;Devices;Diet;Disease;Drug Costs;drug development;drug discovery;Drug Targeting;Environmental Health;Event;evidence base;Exhibits;experience;experimental study;Exposure to;Flame Retardants;Gene Expression;germ free condition;Goals;good laboratory practice;hazard;Hazardous Chemicals;Health;health literacy;Health Personnel;Health Sciences;Home;Human;Human Biology;human tissue;improved;Individual;Industry;insight;Institution;Interdisciplinary Study;interest;International;Knowledge;Laboratories;Learning;Mammals;Manufacturer;Measurable;member;Methods;microbiome;Modeling;Motor Activity;multidisciplinary;National Institute of Environmental Health Sciences;Nature;Noise;Nonprofit Organizations;Oregon;Organ;Organism;Outcome;Pacific Northwest;Pathway interactions;Persons;Pesticides;Pharmacologic Substance;Phenotype;phthalates;Physiology;Poison;Population;Positioning Attribute;Predisposition;Public Health;remediation;Reproducibility;Research;Research Personnel;Research Project Grants;response;Robot;Running;Safety;Sampling;Science;Scientist;Services;Signal Transduction;skills;Soil;Specific qualifier value;Strategic Planning;Structure;success;Techniques;Technology;tool;Toxic effect;Toxic Environmental Substances;Toxicology;Toxin;transcriptomics;Translational Research;Translations;Universities;volatile organic compound;Volatilization;Water;whole genome;Workplace;wristband;Zebrafish

PROJECT_TITLE: Pacific Northwest Center for Translational Environmental Health Research

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


PI_NAMEs: TANGUAY, ROBYN L (contact)

PROJECT_TERMS: Address;adverse outcome;Advisory Committees;Analytical Chemistry;analytical tool;Applications Grants;Award;Awareness;Budgets;career;career development;Categories;Collaborations;Communication;Communities;community engagement;computer infrastructure;Core Facility;Cultural Diversity;data to knowledge;Discipline;Disease;driving force;Educational workshop;Effectiveness;Ensure;Environmental Exposure;Environmental Health;Evaluation;Event;experience;Faculty;Funding;Future;Geography;Goals;Health Personnel;Human Biology;improved;in vivo evaluation;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Joints;Knowledge;knowledge integration;Learning;Life;Manufacturer;meetings;member;Mentors;Mission;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;Nongovernmental Organizations;Oregon;Pacific Northwest;Pathway interactions;Performance;Pharmacologic Substance;Pilot Projects;Postdoctoral Fellow;Problem Solving;Productivity;programs;Public Health;Records;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;response;Science;Scientist;Services;Strategic Planning;Students;success;symposium;synergism;Translations;Universities;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


PI_NAMEs: HO, EMILY  (contact)

PROJECT_TERMS: Abnormal coordination;Biometry;Clinical;Collaborations;Communication;Communities;Core Facility;Data;data interoperability;data management;Data Storage and Retrieval;Decision Making;design;Development;Disease;Educational process of instructing;Ensure;Environmental Exposure;Environmental Health;Evaluation;evidence base;experience;Goals;Health;health literacy;Health Personnel;Health Sciences;Human Biology;improved;indexing;Individual;innovation;instrument;Joints;Knowledge;Laboratories;Lead;Manufacturer;Measurable;member;Methods;Mission;Nature;Nonprofit Organizations;Outcome;Output;Pacific Northwest;Pharmacologic Substance;Production;Protocols documentation;Public Health;Qualifying;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Science;Scientist;Services;Specific qualifier value;success;synergism;tool;Training;Translating;translational engagement;translational impact;translational model;translational pipeline;Translational Research;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Integrated Health Sciences Facilities Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Parenting stress is a well-documented barrier to youth engagement in community-based substance use treatment. The proposed K23 project aims to develop and evaluate a mobile health parenting stress intervention for caregivers of justice-involved youth, a population with high rates of substance use and low rates of treatment engagement. The proposed research will expand the investigator's capacities as an independent health services investigator with expertise in: 1) substance use services research; 2) participatory methods; and 3) mHealth methodology.

PI_NAMEs: FOLK, JOHANNA BAILEY (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent substance use;Adopted;Adoption;Age;antisocial behavior;barrier to care;behavioral health;biological adaptation to stress;caregiver interventions;Caregivers;Child Rearing;Clinical Trials Design;Collaborations;Communities;community based participatory research;community based treatment;community engaged research;community reentry;Competence;Complement;Complex;cost;design;Development;digital;Dropout;dual diagnosis;efficacy testing;Equity;ethnic minority;ethnic minority population;Exhibits;experience;Family;Focus Groups;Foundations;Funding;Future;Gender;Goals;Health Professional;health service use;Health Services;Health Services Research;Health Technology;high risk;Hybrids;improved;Individual;Informatics;interest;Interpersonal Relations;Intervention;Intervention Trial;Justice;K-Series Research Career Programs;Legal;Logistics;Mediator;Mental Health;Mentors;Methods;mHealth;mhealth interventions;mHealth methodology;mindfulness;mindfulness intervention;Mobile Health Application;Motivation;Neighborhoods;novel;novel strategies;Outcome;Persons;Population;Poverty;preference;premature;Privacy;Process;programs;Publishing;Quality of Care;racial minority;racial minority population;Randomized;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;Risk;Self Efficacy;Services;stakeholder perspectives;Stress;substance misuse;substance use;substance use treatment;Symptoms;System;Technology;Therapeutic;therapy design;therapy development;Time;Training;Transportation;treatment as usual;Treatment Efficacy;Trust;Underserved Population;user centered design;willingness;Work;Youth

PROJECT_TITLE: Reducing Parenting Stress to Facilitate Justice-Involved Youth’s Treatment Engagement

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE – HERCULES: EXPOSOME RESEARCH CENTER Using the framework of the exposome, which encompasses the totality of exposures, biological responses and societal factors experienced across a lifespan, the HERCULES: Exposome Research Center at Emory and Georgia Tech work to enhance and extend environmental health research, foster innovation and collaboration, engage with communities and stakeholders, and support research translation to accelerate impact.

PI_NAMEs: MARSIT, CARMEN JOSEPH (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Area;Award;Biological;career;career development;Charge;climate crisis;Collaborations;Communicable Diseases;Communication;Communities;community engaged research;community engagement;community partners;Core Facility;data ecosystem;Data Science;Data Science Core;data science resource;Dimensions;Disease;Ensure;Environment;Environmental Exposure;Environmental Health;environmental health disparity;Evaluation;experience;Exposure to;Extramural Activities;Fostering;Funding;Goals;Growth;Health;Health Priorities;Health Sciences;holistic approach;Home;Human;improved;Individual;Infrastructure;innovation;Knowledge;Laboratories;laboratory facility;Laboratory Research;Leadership;Learning;life span;member;Mentorship;metabolomics;metropolitan;Mind;Mission;National Institute of Environmental Health Sciences;Nongovernmental Organizations;Output;Personal Satisfaction;Pilot Projects;Policies;Prevalence;Program Development;programs;Public Health;Public Health Practice;recruit;Research;Research Personnel;Research Support;Resolution;Resource Development;Resources;response;Risk;Services;Shapes;skills;Societal Factors;Societies;Strategic Planning;Technology;Time;tool;translational engagement;translational goal;translational pipeline;Translational Research;Translations;United States;Universities;Vision;Work

PROJECT_TITLE: HERCULES: Exposome Research Center


PROJECT_TERMS: Administrator;Affect;Appointment;Area;Back;Centers for Disease Control and Prevention (U.S.);Communication;Communities;community partners;Data;Dedications;design;Development;Education;Effectiveness;Ensure;Environmental Health;Evaluation;Event;Feedback;Funding;Future;Goals;Grant;Health;Human;improved;Knowledge;Leadership;Learning;meetings;member;Mentors;Mission;National Institute of Environmental Health Sciences;operation;outreach;Personal Satisfaction;Play;Positioning Attribute;Productivity;programs;recruit;Research;Research Support;Resource Allocation;Resources;Role;Schedule;Scientist;Series;Services;Structure;success;Time;Training;Training Programs;Translations;United States Environmental Protection Agency;United States National Institutes of Health;Universities;Vision;Work;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

PI_NAMEs: ROHLMAN, DIANA  (contact)

PROJECT_TERMS: Agreement;Basic Science;Categories;Center for Translational Science Activities;Clinic;Clinical Research;Collaborations;Communication;Communities;community engaged research;community engagement;Core Facility;Decision Making;Development;Disasters;Discipline;Ensure;Environmental Health;Ethics;Evaluation;experience;Feedback;Funding;Goals;health communication;Health Hazards;health knowledge;health literacy;Health Personnel;Health Sciences;improved;indigenous community;innovation;Interdisciplinary Study;interest;Joints;Knowledge;Language;Lead;Learning;Learning Skill;Legal;literacy;Manufacturer;member;Methodology;Modeling;multimodality;National Institute of Environmental Health Sciences;Nongovernmental Organizations;Nonprofit Organizations;novel;Oregon;Output;Pacific Northwest;Participant;Pattern;Pharmacologic Substance;Politics;population health;Production;programs;Public Health;Publishing;Qualifying;Reporting;Research;research data dissemination;Research Institute;Research Personnel;Research Support;Resources;response;scaffold;scientific literacy;Scientist;social;Special Population;Structure;Techniques;tool;Translating;translational health science;translational impact;translational model;translational pipeline;Translational Research;Trust;United States National Institutes of Health;Visual;Work

PROJECT_TITLE: Community Engagement Core


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Narrative Understanding and being able to manipulate metalloenzyme biochemistry has applications for many aspects of human health and biotechnology (e.g. the production of novel antibiotics and anticancer drugs, sustainable biofuel production, and environmental toxin remediation). With both antibiotic resistance and climate change emerging as major health concerns, the proposed studies are important and timely, and the efforts will result in insights necessary to combat these frontier challenges.

PI_NAMEs: DRENNAN, CATHERINE L (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Metalloenzyme structure, function and assembly


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: BARR, DANA BOYD (contact)

PROJECT_TERMS: Address;analytical method;Animals;Area;Basic Science;Bioinformatics;Biological;Biological Markers;Biological Models;Biology;Cell Culture Techniques;chemical association;Chemicals;Chemistry;Clinical;clinical biomarkers;Clinical Management;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;community partners;complex biological systems;Core Facility;Data;Data Science Core;design;Development;Discipline;Disease;Environment;environmental agent;environmental chemical;Environmental Exposure;Environmental Health;epidemiology study;Evaluation;Evaluation Research;Exposure to;Fostering;Foundations;Funding;Health;Health Sciences;Human;human tissue;innovation;interest;International;Intervention;investigator training;Knowledge;Laboratories;laboratory facility;Leadership;Life;Liquid substance;Mass Spectrum Analysis;Measures;meetings;member;metabolome;metabolomics;Methods;Mission;National Institute of Environmental Health Sciences;novel;Outcome;outreach;Phenotype;Pilot Projects;Population;population based;Population Research;Population Study;programs;Public Health;Research;research facility;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;response;Role;Science;Scientific Inquiry;Scientist;Services;Structure;success;Technology;Testing;Time;tissue culture;tool;training opportunity;Translational Research;Translations;Vision;Work


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed study will establish the feasibility, acceptability, and credibility of a novel, web-delivered mind-body program, "Toolkit for REsilient Life bEyond pain and Substance use-TIRELESS," aimed at adapting to pain and disability among patients with painful non traumatic upper extremity conditions who have co morbid substance use. This sub-group of patients with painful nontraumatic upper extremity conditions experience greater levels of pain and disability, opioid misuse, and medical care utilization, and poor outcomes after medical treatments. A brief, tailored mind-body program delivered to this high-risk population has the potential to decrease risky substance use, improve adaptation to pain and disability, and, in turn, reduce the utilization of orthopedic care services and costs.

PI_NAMEs: BAKHSHAIE, JAFAR  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;Acute;Acute Pain;Address;Adult;Alcohols;Amphetamines;Award;Back;Benchmarking;Biometry;Bypass;Cannabis;care costs;care seeking;care systems;career;career development;Caring;chronic pain;Clinical;Clinical Research;Clinical Trials;Cocaine;comorbidity;Consumption;cost;Data;Development;Diagnostic;disability;efficacy testing;efficacy trial;Electronic cigarette;Elements;Eligibility Determination;emotional distress;Enhancement Technology;Enrollment;Environment;Evidence based intervention;experience;Face;Focus Groups;Fostering;Foundations;Fright;Funding;Goals;Hallucinogens;Health;high risk;high risk population;Hip region structure;improved;improved outcome;Infection;Inhalant dose form;Injections;Injury;injury recovery;innovation;Institution;Internet;Intervention;Interview;Knee;Life;Link;Maps;Medical;meetings;Mentors;Methodology;Methods;mHealth;Mind-Body Intervention;mind/body;Mission;Modeling;multidisciplinary;Musculoskeletal;National Center for Complementary and Integrative Health;novel;Online Systems;Operative Surgical Procedures;Opioid;opioid misuse;Orthopedics;Outcome;Outpatients;Ownership;Pain;pain catastrophizing;Pain management;pain model;pain outcome;palliative;patient subsets;Patients;Pattern;Persistent pain;Persons;Population;preference;prescription opioid;prescription opioid misuse;prevent;primary outcome;Procedures;Process Assessment;programs;promote resilience;psychoeducation;Psychologist;psychosocial;Publications;Qualitative Methods;Randomized;Recovery;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Research Project Grants;resilience;Risk;Risk Factors;screening;secondary outcome;sedative;Self Efficacy;skills;social stigma;Stimulant;Substance Addiction;substance use;Tendinopathy;Testing;therapy development;Thinking;tobacco products;Training;Training Programs;treatment as usual;Upper Extremity;user centered design;web platform;whole health

PROJECT_TITLE: Web-based mind-body treatment to enhance resilience among patients with painful nontraumatic upper extremity conditions and comorbid risky substance use


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WALLER, LANCE A (contact)

PROJECT_TERMS: Acceleration;Affect;analytical tool;archive data;Behavior;Bioinformatics;Biometry;built environment;career;Characteristics;citizen science;Collaborations;Communities;community collaboration;community engagement;community partners;community partnership;community research;community setting;Complement;computerized tools;Connective Tissue;Core Facility;Cost Sharing;Data;Data Analyses;Data Collection;data communication;Data Element;data management;data pipeline;data repository;Data Science;Data Science Core;Data Scientist;Data Set;data sharing;Data Sources;data standards;design;Disease;diverse data;Educational workshop;Elements;Environmental Health;experience;field study;Foundations;Funding;Future;Generations;Genomics;Goals;graduate student;Health;Health Sciences;Human;improved;Incubated;Individual;Informatics;Infrastructure;innovation;insight;Institution;Knowledge;Learning;Link;Machine Learning;mathematical model;Measurable;Measurement;member;metabolomics;Methods;Mind;Mission;Modeling;Monitor;multiple data types;National Institute of Environmental Health Sciences;next generation;novel;operation;Outcome;Personal Satisfaction;Pilot Projects;Policies;Policy Maker;Postdoctoral Fellow;programs;Proteomics;Recording of previous events;remote sensing;Reproducibility;Research;Research Personnel;Research Project Grants;response;Science;science teacher;Scientist;Software Tools;Source;statistical and machine learning;Students;success;Systems Biology;Techniques;Time;tool;Training;training opportunity;transcriptomics;Translating;Translational Research;trend


PI_NAMEs: TRUONG, LISA  (contact)

PROJECT_TERMS: Address;adverse outcome;Advocate;Animals;Applied Genetics;Autopsy;Awareness;Biological Markers;Biomedical Research;Certification;Chemical Exposure;Chemicals;Communities;community engagement;Computer software;Consultations;Core Facility;Diet;Dimensions;Disease;Elements;Environment;Environmental Exposure;Environmental Health;epidemiology study;Event;experimental study;Fishes;Funding;Genetic;Genome;germ free condition;Goals;hazard;Health;health science research;Health Sciences;high throughput screening;Human;human disease;Image;innovation;Institution;instrumentation;Investments;Knowledge;Link;Longitudinal Studies;Microinjections;Modeling;Molecular;nanoparticle;National Institute of Environmental Health Sciences;Operative Surgical Procedures;Oregon;Pacific Northwest;Pathway interactions;Preparation;Production;programs;recruit;Research;Research Personnel;response;Scientist;Services;Strategic Planning;Therapeutic;tool;Toxic effect;Transgenic Animals;Translational Research;United States National Institutes of Health;Universities;water quality;Zebrafish

PROJECT_TITLE: Zebrafish Biomedical Research Facility Core