ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infertility;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Pleiotropy is a poorly understood phenomenon in human genetic disorders wherein defects in a single gene results in multiple seemingly unrelated clinical conditions. In this proposal, the investigators will identity and characterize human genes that interconnect disorders of reproduction and craniofacial development. Using human studies and zebrafish models, this study will help understand the extent of genetic pleiotropy, the reasons behind the pleiotropy of these genes and its effects on overall human health.

PI_NAMEs: BALASUBRAMANIAN, RAVIKUMAR  (contact);DAVIS, ERICA ELLEN

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Affect;Alleles;Animal Disease Models;Atlases;biobank;Biological;Biology;Cartilage;cartilage cell;causal variant;cell type;Clinical;clinical care;clinical investigation;cohort;comorbidity;Complex;Congenital Abnormality;craniofacial;craniofacial development;Craniosynostosis;cranium;Data;Data Set;Defect;Development;developmental genetics;differential expression;Disease;Dissection;Embryo;Ephrins;Erinaceidae;FGFR1 gene;Fibroblast Growth Factor;gain of function;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genomics;Genotype;GLI3 gene;Goals;Gonadotropin Hormone Releasing Hormone;Health;Human;human disease;Human Genetics;human tissue;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;Individual;Joint structure of suture of skull;Link;loss of function;loss of function mutation;Maps;Mendelian disorder;migration;Modeling;Molecular;mutant;Mutation;mutation carrier;neurogenesis;neuron development;Neurons;novel;optimal treatments;Overlapping Genes;Pathogenesis;Pathogenicity;Pathway interactions;personalized genomic medicine;phenome;phenomics;Phenotype;pleiotropism;Population;Precision therapeutics;premature;Prevalence;prospective;Proteins;rare variant;Reporting;Reproduction;Reproductive Endocrinology;reproductive system disorder;Research Personnel;segregation;Signal Transduction;SOX11 gene;Surgical sutures;suture fusion;Testing;Tissues;trait;Transcript;transcription factor;transcriptomics;Transgenic Organisms;Tretinoin;TWIST1 gene;Validation;Variant;Work;Zebrafish

PROJECT_TITLE: Dissection of the Molecular Basis of Pleiotropy Between GnRH Neuronal Development and Cranial Suture Fusion

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: NARRATIVE The mitochondrion is an intracellular organelle most famous for its “powerhouse” role in promoting ATP synthesis. Recent studies have found that mitochondria also have crucial, ATP-independent metabolic roles in supporting cell function, but a detailed understanding of these other mitochondrial functions is lacking. This proposal seeks to disrupt mitochondrial processes and measure the effects on cell metabolism and cell function to gain a new, holistic understanding of the metabolic functions of mitochondria and to identify therapeutic targets for diseases associated with mitochondrial dysfunction, including mitochondrial diseases, neurodegeneration, cancer, aging, and others.

PI_NAMEs: SULLIVAN, LUCAS BRYAN (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Aging;Amino Acids;Aspartate;ATP Synthesis Pathway;Binding;Biochemical;Biochemical Process;Bioenergetics;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;Clinical;Collection;Complex;Cytosol;Data;Development;Disease;Electron Transport;Functional disorder;heart cell;Human;Impairment;Inborn Errors of Metabolism;Life;Malignant Neoplasms;Measures;Membrane;Metabolic;Metabolic Pathway;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial metabolism;NADH dehydrogenase (ubiquinone);Natural regeneration;Nerve Degeneration;novel;Organelles;Oxidants;Oxidation-Reduction;Process;Production;programs;Research;Role;Signal Transduction;Succinate dehydrogenase (ubiquinone);Supporting Cell;System;targeted treatment;therapeutic target;Work

PROJECT_TITLE: Understanding metabolic functions of mitochondria in proliferating cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This project is directed at developing an innovative nanoplatform wholly composed of recombinant proteins, and using it for combination therapeutic studies for triple-negative breast cancer.

PI_NAMEs: LIU, RIHE  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;antigen binding;Antigens;Binding;Biological Process;Body Temperature;Breast Cancer Cell;Breast Cancer cell line;Calmodulin;cancer type;chemical conjugate;Chemoresistance;chemotherapy;Chimeric Proteins;Combination immunotherapy;Combined Modality Therapy;Cysteine;Development;Docking;ecto-nucleotidase;effective therapy;Elastin;Engineering;Epidermal Growth Factor Receptor;ERBB2 gene;ERBB3 gene;Estrogen Receptors;extracellular;FZD7 gene;Genes;Genetic;Genetic Engineering;high risk;Histopathologic Grade;Homing;hormone receptor-positive;Human;Human body;Hydrolysis;immunogenicity;Immunosuppression;inhibitor;innovation;interest;Malignant Breast Neoplasm;Mediating;Micelles;Monoclonal Antibodies;mouse model;Mus;nanobodies;nanometer;nanoparticle;nanotechnology platform;Neoplasm Metastasis;novel;Nucleosome Core Particle;overexpression;Pathway interactions;Peptides;phosphatidylinositol 3-kinase gamma;PIK3CG gene;polypeptide;Process;Progesterone Receptors;programmed cell death ligand 1;Proteins;receptor;Recombinant Proteins;Recombinants;Relapse;self assembly;Side;siRNA delivery;Small Interfering RNA;Specificity;standard care;stemness;Surface;Surface Antigens;System;targeted delivery;targeted treatment;Temperature;Tertiary Protein Structure;Therapeutic;Therapeutic Agents;Therapeutic Studies;Toxic effect;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor initiation;WNT Signaling Pathway

PROJECT_TITLE: A Wholly Protein-based Self-assembly Nanoplatform for TNBC-specific Combination Therapy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE  Numerous pathologies, tissue deficits, and injuries involve microvascular dysfunction and would significantly benefit from innovative approaches to better understand angiogenesis and vessel rarefaction. This project attacks these significant global health problems and addresses several objectives of the NHLBI Strategic Vision by further developing an emerging cell force biosensor platform to better understand the importance of pericytes in vasculogenesis and angiogenesis. Project outcomes are expected to demonstrate engineered control of pericytes during microvascular expansion and rarefaction in physiological and pathophysiological conditions.

PI_NAMEs: NAIN, AMRINDER ;PHILLIPPI, JULIE A (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Affect;Anastomosis - action;Aneurysm;angiogenesis;Architecture;Atherosclerosis;Beds;Biochemical;Biocompatible Materials;Biological;Biological Models;biophysical properties;Biophysics;Biosensor;Blood Island;Blood Vessels;bone repair;cell motility;Cells;Cellular Morphology;Chemicals;Contractile Proteins;Coupling;Cues;cytokine;Cytoskeleton;density;design;Development;diabetic ulcer;Diameter;Disease;Endothelial Cells;Endothelium;Engineering;Exertion;Exhibits;experimental study;Extracellular Matrix;Fiber;fiber cell;Fibronectins;Gene Expression;Generations;Genetic;global health;Goals;Growth;Heterochromatin;Hindlimb;human tissue;Hydrogels;Hypoxia;Immunocompromised Host;Implant;In Situ;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;injured;Injury;innovation;Intermediate Filaments;Knowledge;Malignant Neoplasms;matrigel;Measures;Methods;Microtubules;Microvascular Dysfunction;migration;Morphology;Mus;Myocardial Infarction;nanofiber;Nanofiber Scaffold;National Heart, Lung, and Blood Institute;neovascularization;novel;Nuclear;Outcome;Oxidative Stress;Oxygen;Pathology;Pattern;Perfusion;Pericytes;Peripheral arterial disease;Phenotype;phenotypic biomarker;Physiologic Neovascularization;Physiological;Polystyrenes;protein expression;public health relevance;Publishing;pulmonary arterial hypertension;Reactive Oxygen Species;Rho-associated kinase;Role;scaffold;Shapes;spheroids;Strategic vision;Structure;subcutaneous;System;technology platform;Testing;Time;Tissue Engineering;Tissues;transcriptomics;transdifferentiation;translational impact;Transplantation;vascular tissue engineering;Vascularization;vasculogenesis;Vasculogenic;volumetric muscle loss;Work

PROJECT_TITLE: Matrix biophysics and pericyte mechanobiology in (patho)physiological angiogenesis


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: In response to RFA-AI22-024 we propose “Exploring, Predicting, and Intervening on Long-term Viral suppression Electronically (EPI-LoVE)” to enroll, retain, analyze HIV care outcomes, and test digital health interventions among a large diverse digital cohort of people living with HIV (PLWH) who are struggling to engage with care and maintain consistent viral suppression. With multiple recruitment methods including social media and AIDS Healthcare Foundation current and former patients, we employ an evidence-based digital platform (HealthMpowerment, HMP) and multiple data sources (e.g., surveys, biologic specimens, app data). Capitalizing upon cross- cutting expertise to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the US we will identify the digital strategies that address the intersectionality of this ongoing public health crisis.

PI_NAMEs: GORBACH, PAMINA MAE (contact);HIGHTOW-WEIDMAN, LISA B;YOUNG, SEAN

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Advertising;African American;Age;Age Years;Anti-Retroviral Agents;antiretroviral therapy;Articulation;Artificial Intelligence;artificial intelligence model;Assessment tool;Back;barrier to care;Behavior;behavior change;Behavioral;Biological;Biological Markers;Black American;Black Populations;Black race;Blood specimen;Blood Specimen Collection;California;care outcomes;care providers;Caring;Clinic;Clinical;cohort;Collaborations;Collection;Communication;contextual factors;Country;Data;Data Collection;Data Set;digital;digital health;digital intervention;digital platform;Disease;Disparity;Drug user;Enrollment;Ensure;Epidemic;Epidemiologic Methods;Epidemiology;evidence base;Evidence based intervention;experience;experimental study;Foundations;Geography;health inequalities;Healthcare;high risk;HIV;Home;Individual;Injectable;Injecting drug user;Institution;intersectionality;Intervention;Laboratories;Longitudinal cohort;Longitudinal cohort study;Los Angeles;Love;machine learning method;Medical;Mental Health;Methods;Modeling;Movement;multiple data sources;Nature;North Carolina;novel;Outcome;outreach;Participant;Patients;Patterns of Care;Persons;Phase;Productivity;prospective;Provider;Public Health;Recording of previous events;recruit;Regimen;Reporting;Research;response;Risk;Risk Assessment;Risk Factors;Rural;rural area;social;Social Distance;social media;social stigma;Specimen;structural determinants;substance use;Surveys;syndemic;Testing;Time;tool;Treatment Efficacy;United States;Universities;Viral;Viral Epidemiology;Viral Load result;Vulnerable Populations;web site;Youth


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Parkinson disease (PD) is an incurable and progressive neurodegenerative condition marked by the accumulation of ⍺-synuclein in affected neurons. To inform innovative therapeutic strategies with disease- modifying potential, this proposal takes advantage of a human induced pluripotent stem cell (iPSC) PD model system to investigate the autophagy suppressor, myotubularin-related phosphatase 5 (MTMR5). These studies promise to reveal discrete therapeutic targets for selectively augmenting autophagy in neurons and reducing neuronal death in PD, while simultaneously uncovering the unique biology of myotubularins and their contribution to autophagy flux in neurons.

PI_NAMEs: CHUA, JASON PAUL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;alpha synuclein;Automobile Driving;Autophagocytosis;Autophagosome;Bioinformatics;Biological Models;Biology;career;career development;Cell Death;Cell model;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR interference;CRISPR screen;Cytoplasmic Inclusion;Cytoprotection;design;Development Plans;disability;Disease;disease model;Disease Progression;Doctor of Medicine;Doctor of Philosophy;Educational workshop;experience;Fellowship;Genes;genome-wide;Goals;Half-Life;high throughput screening;Home;Human;human induced pluripotent stem cells;Imaging Techniques;Impairment;Induced Neurons;Induced pluripotent stem cell derived neurons;innovation;Institution;Investigation;knock-down;Knowledge;Label;Late-Onset Disorder;Learning;Measures;meetings;Mentors;Mentorship;Metabolism;Methods;Motor;mouse model;Movement Disorders;mTOR inhibition;mutant;myotubularin;Nerve Degeneration;Neurodegenerative Disorders;Neurology;neuron loss;neuronal survival;Neurons;neuroprotection;Neurosciences Research;North America;novel;nutrient deprivation;Optics;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physicians;Physiologic pulse;Population;Positioning Attribute;Predisposing Factor;prevent;Principal Investigator;Program Development;Proteins;proteostasis;proteotoxicity;Publishing;Recycling;Regulation;Research;Research Technics;Residencies;Resources;Scientist;skills;Spinobulbar Muscular Atrophy;Stimulus;symptom management;Symptoms;Testing;Therapeutic;therapeutic target;therapy design;therapy development;Tissues;Toxic effect;Training;Transcript;translational neuroscience;Work

PROJECT_TITLE: Rescuing ⍺-synuclein toxicity through neuron-specific enhancement of autophagy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Services;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: This project is directly relevant to public health concerns related to the effects of prenatal alcohol exposure on child health and development. This study aims to improve the screening of FASD by deploying web-based tools that aid in clinical evaluation. Two main tools will be used, the FASD-Tree and the Brief Assessment of Individual Neurobehavior – online version (BRAIN-online). Both tools use web-based technology for collecting data and provide the clinician with information about the individual’s physical, behavioral, and cognitive attributes. Data from these novel tools will be combined with traditional and advanced physical measurements collected through other CIFASD projects and will enhance clinical decision-making.

PI_NAMEs: MATTSON WELLER, SARAH N (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Affect;Age;Alaska;Alcohol-Related Neurodevelopmental Disorder;Alcohols;Attention;Behavior;Behavioral;brief screening;Canada;Child;Child Development;Child Health;Classification;classification trees;Clinic;Clinical;clinical decision-making;clinical diagnosis;Cognitive;cognitive testing;Collaborations;Computers;cost;cost effective;Data;demographics;Detection;Diagnostic;diagnostic tool;Dysmorphology;Electronic Mail;Evaluation;Face;Feedback;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;high risk;Home;Image;Imaging Device;improved;Impulsivity;Individual;interest;Intervention;Link;Measurement;Measures;medical specialties;Memory;Minnesota;Motor;neurobehavior;Neuropsychological Tests;Neuropsychology;novel;Online Systems;online version;Outcome;Output;Parents;Patients;Performance;Persons;Phase;Physical Examination;prenatal testing;Problem Solving;Process;processing speed;Public Health;Questionnaires;Reaction Time;Records;recruit;Research;research clinical testing;Research Personnel;Resources;response;Risk;Sample Size;Sampling;screening;Screening procedure;Short-Term Memory;social media;special interest group;Specificity;Speed;Standardization;System;Technology;Telemedicine;Test Result;Testing;tool;Training;transcranial direct current stimulation;Trees;Visit;Wait Time;web-based assessment;web-based tool;Youth

PROJECT_TITLE: Assessment of Fetal Alcohol Spectrum Disorders (FASD) Using Novel Web-Based Tools


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Pain Research

ORG_CITY: LA JOLLA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed research is relevant to public health because the research findings will elucidate mechanisms for effects of slow stroking and deep pressure – components of massage therapy – on touch pleasantness and pain modulation. The proposed research will also characterize a novel pathway for affective deep pressure and elucidate its peripheral and central mechanisms, opening new horizons in mechanistic research on massage. The project is relevant to NCCIH’s mission because it addresses fundamental, real-time mechanistic processes of components of massage therapy.

PI_NAMEs: CASE, LAURA K (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Ablation;Address;Adult;Affective;Afferent Pathways;Amyloid beta-Protein;Anterior;Anterolateral;Area;Brain;Brain imaging;C Fiber;Central Nervous System;chronic pain;cingulate cortex;Clinical;Complementary therapies;Complex;Cordotomy;Data;Deafferentation procedure;Dedications;Dependence;Disease;Esthesia;Evaluation;Fiber;Functional Magnetic Resonance Imaging;Goals;Health;heart rate variability;Impairment;Individual;Individual Differences;individual response;innovation;Insula of Reil;Interneurons;Left;Light;Local Anesthetics;Machine Learning;Manipulative Therapies;Maps;Massage;mechanotransduction;Methods;Mind-Body Intervention;Mission;National Center for Complementary and Integrative Health;Nerve compression syndrome;Nerve Fibers;Neural Pathways;neuromechanism;neuroregulation;Nociceptors;novel;Outcome;Pain;Pain management;Pain Measurement;pain reduction;pain relief;Parasympathetic Nervous System;Pathway interactions;Patients;Peripheral;predictive modeling;preference;preservation;pressure;Process;Public Health;Relaxation;Relaxation Therapy;Research;Research Personnel;response;Role;secondary outcome;Signal Transduction;Skin;Somatosensory Cortex;Spinal;Strategic Planning;Stroke;Study Subject;Tactile;Temperature Sense;Testing;theories;Time;tool;Touch sensation;volunteer

PROJECT_TITLE: Dynamic Evaluation of Neural Mechanisms for Affective Touch: Pathways for Touch-induced Pleasantness and Pain Modulation

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  The Data Coordination Resource will create an integrated database consisting of a vast array of data collected from the CIFASD projects in an effort to accurately recognize those with prenatal alcohol exposure (PAE), improve interventions to mitigate the effects of PAE, better understand the effects of PAE across the lifespan, and to reduce the incidence of PAE. These data will be shared with the broader research community, contributing to further understanding the effects of PAE and enhance future clinical and translational research.

PI_NAMEs: WETHERILL, LEAH  (contact)

PROJECT_TERMS: Alcohol consumption;archived data;Archives;Child;Clinical;Clinical Investigator;Clinical Research;Collaborations;Communities;Consent;dashboard;Data;data archive;Data Collection;data dictionary;data exchange;data sharing;Databases;Deposition;effective intervention;effective therapy;Ensure;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;first grade;Future;Goals;Human Subject Research;improved;Incidence;Informed Consent;instrument;Interdisciplinary Study;Intervention;life span;National Institute on Alcohol Abuse and Alcoholism;online registry;Participant;Plant Leaves;Policies;Pregnancy;Pregnant Women;programs;recruit;Reporting;Research;Research Personnel;Resources;Role;Scientist;success;Time;Translational Research;United States;United States National Institutes of Health;user-friendly;Validation

PROJECT_TITLE: Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) Data Coordination Resource


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse;Telehealth

PHR: Project Narrative The consequences resulting from prenatal alcohol exposure are wide-ranging, a major and costly public health problem, and can be life-long and impact numerous body systems. The goals of CIFASD are to improve the recognition of fetal alcohol spectrum disorders (FASD), implement interventions, and increase the capacity for dealing with these effects. Utilizing the resources of a multisite, multidisciplinary collaboration, CIFASD can address issues not achievable by individual projects.

PI_NAMEs: RILEY, EDWARD P (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adult;Advisory Committees;Affect;Age;age acceleration;Archives;Area;Behavioral;Biological Markers;Body System;Cardiac;Charge;Clinical;clinical practice;Clinical Research;cohort;Collaborations;Communication;cost;cytokine;Data;Data Collection;data dictionary;Data Files;data management;data sharing;Databases;Deposition;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic value;Disease;Dissemination and Implementation;drinking;Dysmorphology;Education;eHealth;Elements;Ensure;epidemiology study;Evaluation;Face;falls;Family;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal diagnosis;forging;Functional disorder;Future;Goals;Health;health care service;Hybrids;Hypertension;Immune;implementation efforts;implementation science;improved;Individual;Inflammatory;Information Dissemination;Infrastructure;innovation;Interdisciplinary Study;International;Intervention;Language;Leadership;life span;maternal alcohol use;meetings;member;MicroRNAs;Mission;Modality;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;news;novel;Outcome;outreach;Pattern;Persons;Play;Policies;Population;pre-clinical research;preclinical study;Prevalence;Prevention;Prevention strategy;Privatization;Progress Reports;Protocols documentation;Provider;Public Health;Publications;recruit;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Risk;Risk Factors;Risk Reduction;Role;Schedule;Science;Scientist;screening;Services;Site;Structure;Suggestion;symposium;System;Technology;Telemedicine;Testing;tool;web site;Woman;Work;Writing

PROJECT_TITLE: Administrative Resource of the CIFASD


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The epigenetic machinery is essential for the proper regulation of gene expression, and mutations in components of this machinery can have wide-ranging effects on development and human health. A deeper understanding of how defects in the epigenetic machinery contribute to disease is currently hindered by our lack of knowledge about how different cell types are affected when components of the epigenetic machinery are perturbed. The proposed research will address this gap in knowledge by dissecting gene regulatory changes in mouse embryos engineered to carry precise mutations in epigenetic regulators, yielding deep insights into the functions of epigenetic regulators as well as fundamental mechanisms of gene regulation in development and disease.

PI_NAMEs: GORKIN, DAVID USCHER (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Affect;Alleles;ATAC-seq;Catalogs;cell type;Cells;Cellular Structures;Chromatin;Complex;Congenital Abnormality;Data;Data Analyses;Data Set;Defect;Development;Developmental Biology;Diagnostic;Disease;disorder risk;DNA Methylation;DNA Sequence;Elements;Embryo;Engineering;Epigenetic Process;epigenome;epigenomics;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Generations;Genes;genetic information;genetic regulatory protein;Genetic Transcription;genome database;Goals;Health;Histologic;histone modification;Human;human disease;human tissue;in vivo;Individual;Informatics;insight;Instruction;International;Knock-out;Knowledge;large scale production;life span;loss of function mutation;mammalian genome;microCT;Molecular;molecular phenotype;Morphology;mouse genome;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;novel;Nuclear RNA;Organism;Patients;Phenotype;phenotypic data;Pregnancy;Property;Reading;Regulatory Element;Research;Resolution;Resources;Review Committee;Role;screening;sex;single cell analysis;Technology;technology platform;The Jackson Laboratory;Therapeutic;Tissue Harvesting;Tissues;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Untranslated RNA;Variant;web based interface;web interface;Writing

PROJECT_TITLE: Single-cell epigenomic phenotyping of IMPC-generated mouse lines lacking chromatin regulators

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Patients with corneal injuries or disease can develop limbal stem cell deficiency (LSCD), resulting in blindness due to an irreversibly opaque cornea. While donor allogeneic ABCB5+ LSC transplants are currently already being evaluated as a therapeutic cell source for patients with bilateral LSCD, we hypothesize that it is also possible, in order to avoid immunosuppressive therapy for prevention of allograft rejection, to manufacture and expand autologous ABCB5+ LSCs for treatment of patients with bilateral LSCD using (i) full reprogramming in vitro, (ii) partial epigenetic reprogramming in vivo, and (iii) ligand-based activation of LSC signaling pathways. These autologous ABCB5+ LSC are anticipated to fully regenerate and maintain a normal limbus and corneal epithelium.

PI_NAMEs: FRANK, MARKUS H. (contact);FRANK, NATASHA Y;KSANDER, BRUCE R

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: adult stem cell;Allogenic;allograft rejection;Autologous;Bilateral;Blindness;c-myc Genes;Cell Physiology;Cell Surface Proteins;Cells;Chronic;Clinical;Clinical Trials;Cornea;Corneal Diseases;corneal epithelium;Corneal Injury;corneal regeneration;Corneal Stroma;Development;differentiation in vitro;Epigenetic Process;Epithelium;Europe;Eye;FDA approved;functional restoration;Funding;Generations;Genes;Grant;Homeostasis;Human;human induced pluripotent stem cells;human tissue;Immune;Immunosuppressive Agents;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;injured;Ligands;limbal;manufacture;Molecular;Monoclonal Antibodies;Mus;Natural regeneration;Nature;neovascularization;next generation;novel strategies;Organoids;Pathway interactions;Patients;prevent;Prevention therapy;programs;Progress Reports;Publications;R24;repaired;Reporting;Research;Research Project Grants;Residual state;restoration;self-renewal;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Skin;Source;stem cell organoids;stem cell population;stem cell proliferation;Stem cell transplant;stem cells;success;Surface;Testing;Therapeutic;Therapeutic immunosuppression;Therapeutic Trials;Transplantation;Vision

PROJECT_TITLE: ABCB5-positive stem cells for LSCD therapy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: THRIVE NEUROMEDICAL, LLC

ORG_STATE: OH

PHR: PROJECT NARRATIVE Preterm born infants are at high risk for neurosensory impairments and developmental delays. In the NICU, infants are often deprived of infant-directed parental speech because of numerous challenges to parental visitation, resulting in reduced differentiation of speech sounds, altered brain structure and poor language outcomes. The result of this proposal will be a fully developed clinical device ready for submission to FDA for clearance, utilizing caregiver recorded infant-directed speech as the first intervention specifically designed for preterm infants and their brain development.

PI_NAMEs: KOCH, DEAN R (contact);MAITRE, NATHALIE

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 2 year old;Active Learning;Address;Adult;Affect;Age;Auditory;Auditory Perception;auditory processing;auditory stimulus;Auditory system;awake;Behavior assessment;Birth;Brain;brain based;Calibration;Caregivers;Caring;Child;Clinical;clinical practice;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive development;Complex;Data;design;Development;Developmental Delay Disorders;Devices;early childhood;Economics;effective intervention;Electroencephalography;empowerment;Ensure;Environment;experience;Exposure to;Family;family support;Foundations;Funding;Geography;health determinants;Hearing;high risk;Hospitalization;Hospitals;Human;Impairment;improved;improved outcome;Incubators;infancy;Infant;Infection Control;infection risk;innovation;Intervention;intervention effect;Justice;Language;Language Delays;Language Development;language outcome;language processing;Learning;Loudness;manufacture;Marketing;Measurement;Measures;medically necessary care;Mothers;Neonatal Intensive Care Units;neural;neural circuit;neurosensory;Newborn Infant;Noise;Nurses;Outcome;Outcome Measure;Pacifiers;Parents;Pattern;peer;Phase;Physiological;Policies;Population;Pregnancy;premature;Premature Birth;Premature Infant;pressure;Process;product development;Protocols documentation;prototype;psychologic;Randomized;Randomized, Controlled Trials;Reading;Recommendation;Research;research and development;response;Safety;Schedule;School-Age Population;sensor;social;social health determinants;sound;Speech;Speech Sound;standard care;Stimulus;Structure;sucking;System;targeted treatment;Team Nursing;Technology;technology intervention;Testing;Therapeutic;Time;United States;Universities;Uterus;verbal;Voice

PROJECT_TITLE: Development of a Therapeutic Device to Improve Speech Sound Differentiation in Preterm Infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Overall The proposed NCBIB will develop and provide broad access to powerful new microscopic imaging tools for biological and clinical research. These instruments will open new avenues of biomedical research and may enable the identification of new methods for diagnosis, provide new insights into disease or disease progression, or lead to the formulation of new therapeutic strategies or drug targets.

PI_NAMEs: BOUMA, BRETT E (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adoption;Algorithms;Angiography;Area;Artificial Intelligence;Biological;biological research;Biology;Biomedical Engineering;biomedical imaging;Biomedical Research;Birefringence;Blood flow;Characteristics;Clinical;clinical diagnosis;clinical imaging;Clinical Research;clinical research site;Collaborations;commercialization;Communication;Communities;Computer software;contrast imaging;Data;Data Analyses;Dependence;Development;Diagnosis;Diameter;Disease;Disease Progression;Drug Targeting;Educational workshop;Engineering;experience;experimental study;Fiber Optics;Formulation;Fostering;frontier;Functional Imaging;Funding;Gastrointestinal Endoscopy;Geographic Distribution;Goals;Hand;Head;Image;image guided;image processing;Imaging Device;imaging platform;imaging system;Imaging technology;improved;Individual;innovation;insight;Instruction;instrument;instrumentation;Internet;Investigation;Lasers;Lead;Light;light scattering;Machine Learning;Maps;Medical;Medical Imaging;Medicine;Methods;Microscope;microscopic imaging;minimally invasive;Mission;Needles;Nerve;Neuroanatomy;neurosurgery;novel;novel therapeutic intervention;operation;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Physics;Pilot Projects;polarimetry;post-doctoral training;pre-clinical;pre-clinical research;pre-doctoral;programs;Publications;recruit;Research;Research Personnel;Resolution;Resources;response;Retina;Retinal Diseases;Rewards;Scientist;Services;Shapes;signal processing;Site;social media;Source;Speed;symposium;System;Techniques;Technology;technology research and development;Tissue imaging;Tissues;tool;Training;Training Programs;Translations;Vascular Diseases;Work

PROJECT_TITLE: Center for Biomedical OCT Research and Translation


NIH_SPENDING_CATS: Biotechnology

PROJECT_TERMS: Clinical;Communities;Ensure;General Hospitals;Guidelines;Infrastructure;Institution;Liquid substance;Massachusetts;meetings;operation;pre-clinical;Procedures;professor;Reporting;Research;Resources;responsible research conduct;Services;Structure;Technology;Training;Translations;United States National Institutes of Health

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PROJECT_TERMS: 3-Dimensional;Acceleration;adaptive optics;Address;Advanced Development;angiogenesis;Angiography;animal imaging;Animal Model;Animals;Axon;axonal degeneration;Biological;Blood capillaries;Blood Vessels;Caliber;Clinical;clinical application;Communities;Data;density;Development;Diabetic Retinopathy;Diagnosis;Dimensions;Disease;disease model;Early Diagnosis;Functional Imaging;Glaucoma;Human;Image;Imaging Techniques;improved;in vivo;Individual;interest;light scattering;Methods;Modality;Monitor;multiple sclerosis treatment;Mus;Neuroprotective Agents;novel;Ophthalmology;Optics;Pathway interactions;Perfusion;Physics;polarimetry;pre-clinical;preservation;Pupil;Research;Resolution;Retina;retinal axon;retinal imaging;Rodent Model;Sampling;signal processing;Signal Transduction;Structure;Techniques;Technology;Three-Dimensional Imaging;Tissues;Tomogram;tool;Translations;Tumor Biology;tumor microenvironment;virtual;Visualization

PROJECT_TITLE: TRD1: Functional Imaging


NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because, gaining a better mechanistic understanding of how natural immune responses in the liver control malaria is expected to promote the development of novel anti- malarial drugs and vaccines. Thus, the proposed research is relevant to the core mission of the NIH pertaining to acquisition of fundamental knowledge about the nature and behavior of living systems, and the application of that knowledge to enhance health, and reduce the burdens of illness in our society.

PI_NAMEs: KURUP, SAM  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Ablation;adaptive immune response;Anti-malarials;Apoptosis;Area;Artemisinins;Attenuated;Autophagocytosis;Behavior;Binding Proteins;Biochemical;Blood;burden of illness;cell type;Cells;Clinical;Culicidae;Cytolysis;Cytosol;Development;Disease;Drug resistance;Enterobacteria phage P1 Cre recombinase;Erythrocytes;experimental study;Exposure to;flexibility;Fostering;Gene Modified;Genes;global health;Goals;Guanosine Triphosphate Phosphohydrolases;guanylate;Health;Hepatocyte;Human;Image;Immune response;Immunity;Immunologics;Immunology;improved;In Vitro;in vivo;Infection;Inflammasome;innate immune mechanisms;innate immune pathways;Innate Immune Response;innovation;Interferon Type I;Interferons;Knowledge;Licensing;Liver;Lysosomes;Malaria;malaria infection;Malaria Vaccines;Mediating;Mediator;Membrane;Mission;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mus;Natural Immunity;Nature;novel;novel strategies;novel therapeutics;Organism;Parasite resistance;Parasites;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Plasmodium;Plasmodium vivax;Population;prevent;Process;Proteins;Public Health;Publishing;Reactive Inhibition;Reactive Oxygen Species;recruit;Relapse;Reporter;Research;Series;Severities;Signal Induction;Signal Pathway;Signal Transduction;Societies;Southeastern Asia;Therapeutic;therapeutic target;tool;transmission process;United States National Institutes of Health;vaccine candidate;Vaccines;Vacuole

PROJECT_TITLE: Type-I Interferons drive cell-autonomous immunity to malaria

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE We have conducted a pilot study of an intervention for children with neurodevelopmental abnormalities resulting from prenatal alcohol exposure (PAE) that consists of a combination of computerized cognitive training (attention and executive functioning) and strategic brain stimulation (transcranial direct current stimulation (tDCS)) - which is very low voltage stimulation designed to momentarily enhance “plasticity” in the cortex. The study will test five initial sessions of cognitive training and active tDCS vs. sham tDCS (placebo) and then go on to test two different dosages (5 active sessions vs. 10 active sessions). Outcome measures will assess attention, executive functioning, parent-reported behaviors related to these underlying cognitive functions, and functional brain network changes using state-of-the-art functional MRI methodologies.

PI_NAMEs: WOZNIAK, JEFFREY ROBERT (contact)

PROJECT_TERMS: Adolescent;Age;arm;Attention;Attention deficit hyperactivity disorder;attentional control;Behavior;Behavioral;behavioral impairment;Brain;Child;Client;Clinical;clinical implementation;Clinical Trials;Cognition;cognitive control;Cognitive deficits;cognitive function;cognitive performance;cognitive training;comparison intervention;computerized;Craniofacial Abnormalities;Data;design;Development;dosage;Dose;emotional functioning;executive function;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional Magnetic Resonance Imaging;Future;Genetic Complementation Test;Growth;Hour;Impaired cognition;Impairment;improved;Independent Living;Individual;Intervention;Intervention Studies;Investments;Learning;Left;Life;Link;Measures;Mediating;Mental Health;Methodology;neural;Neurocognitive;Neurologic;Neuronal Plasticity;neuroregulation;Outcome;Outcome Measure;Parents;Participant;Performance;performance tests;Pilot Projects;Placebos;Population;post intervention;Prefrontal Cortex;Public Health;Publishing;Randomized, Controlled Trials;Regimen;Reporting;Research;response;Rest;safety and feasibility;Short-Term Memory;Social Functioning;social skills;sustained attention;Symptoms;Testing;Therapeutic;Time;Training;transcranial direct current stimulation;treatment effect;voltage

PROJECT_TITLE: tDCS and cognitive training as a neurodevelopmental intervention in FASD


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PI_NAMEs: VAKOC, BENJAMIN JAMES (contact)

PROJECT_TERMS: Accidental Injury;Address;Algorithms;Alzheimer’s disease biomarker;Angiography;Architecture;Blood flow;Blood Vessels;Cardiac;Clinical Management;Clinical Research;Collaborations;Communities;contrast enhanced;CYP1A2 gene;Data;design;Diabetic Retinopathy;Diagnostic Imaging;Disease;early detection biomarkers;Equipment;Eye;first-in-human;Flowmetry;Forehead;frequency comb;Fright;Functional Imaging;Funding;Head;Head and neck structure;Human;Image;Image-Guided Surgery;Imaging Device;imaging platform;imaging system;implantation;improved;Industry;innovation;innovative technologies;instrument;Investigation;Light;Lymphangiography;Maps;Methods;Microscope;Morbidity - disease rate;Nerve;novel;novel strategies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Patients;Perfusion;Peripheral;Peripheral Nerves;Physiologic pulse;Positioning Attribute;prevent;Procedures;programs;Research;Research Personnel;Retina;Retinal Diseases;retinal imaging;Retinopathy of Prematurity;routine imaging;Scientist;Source;Speed;Surgeon;Surveys;System;systems research;Techniques;technological innovation;Technology;Thyroidectomy;Time;Tissues;tool;translational impact;Translations;United States National Institutes of Health;Update;Vagus nerve structure;vascular bed;Visualization;Work

PROJECT_TITLE: TRD2: Circular Ranging OCT


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: VILLIGER, MARTIN  (contact)

PROJECT_TERMS: 3-Dimensional;Address;algorithm training;Algorithms;Architecture;Axon;Birefringence;Blood flow;Brain;brain tissue;Catheters;clinical investigation;Collagen;Collection;contrast imaging;Coronary;Coronary Arteriosclerosis;Coronary artery;cost;Deep Brain Stimulation;deep learning;deep neural network;design;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Dimensions;Electrodes;Elements;Encapsulated;Exhibits;experience;Feedback;Fiber;Fiber Optics;flexibility;Funding;Gastrointestinal tract structure;generative adversarial network;Goals;handheld equipment;Human;Human body;Image;Imaging Device;imaging probe;imaging system;Impairment;implantation;improved;insight;instrument;interstitial;Intervention;Light;Lighting;Lung;Machine Learning;malignant mouth neoplasm;Maps;Measures;Methods;microendoscope;Microscopic;Motor;Muscle Cells;Needles;network architecture;neural network;Neuroanatomy;neurosurgery;Neurosurgical Procedures;novel;novel strategies;Operative Surgical Procedures;Optics;Organ;Pathology;Patients;Performance;Phase;Physics;Procedures;Property;Research;Resolution;Sampling;Scanning;Side;Signal Transduction;Skin Cancer;Staging;Structure;success;Techniques;three-dimensional visualization;Time;Tissues;Tomogram;Training;training data;transfer learning;Translations;ultra high resolution;Variant;Visualization;white matter

PROJECT_TITLE: TRD3: Endoscopic and Probe-based Coherence Imaging


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Prediabetes (PD) and type 2 diabetes (T2D) affect 122 million Americans and are critically underdiagnosed— 81% and 23% of those with PD and T2D, respectively, are unaware that they have the condition. Screening guidelines for PD and T2D have been unable to mitigate this severe diagnostic gap due to their coarseness, subjectivity, and poor performance (e.g., low positive predictive value). The ultimate goal of this research is to develop and implement an innovative, practical, and scalable PD and T2D detection strategy by leveraging digital data obtained using personal consumer smart devices (smartphones and smartwatches) to improve the yield and reach of PD and T2D screening.

PI_NAMEs: DUNN, JESSILYN P (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Adult;Affect;Age;American;Arrhythmia;Autonomic Dysfunction;Awareness;Behavioral;Cardiovascular system;Cellular Phone;Characteristics;Chronic;Clinical;Communities;Continuous Glucose Monitor;cost;Data;Detection;Devices;diabetes management;Diabetes Mellitus;Diagnosis;Diagnostic;Digital biomarker;digital data;Early Diagnosis;Economic Burden;Electronic Health Record;fitbit;Food;General Population;Glucose;Glycosylated Hemoglobin;Goals;Guidelines;Habits;handheld mobile device;Health;health data;Heart Rate;heart rate variability;improved;innovation;interstitial;Intervention;Knowledge;Machine Learning;Measures;Methods;mHealth;mobile computing;Modeling;Monitor;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Parameter Estimation;Patient Self-Report;Patients;Performance;Persons;Physical activity;Physiological;Pilot Projects;Population;Prediabetes syndrome;Predictive Value;prevent;Recommendation;Research;Respiration;response;Rest;Risk;Sampling;Schedule;screening;screening guidelines;sedentary;sensor;Sleep;smart device;smart watch;success;Technology;Testing;Text Messaging;Time;Training;Translating;wearable device;Work;wristband

PROJECT_TITLE: Mobile technologies to screen for prediabetes and type 2 diabetes in asymptomatic adults

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Sleep Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Individuals with Alzheimer’s disease and related dementias (ADRD) and their spouses commonly experience sleep problems that may have negative consequences for their psychological well-being and cognitive function. This project will collect data from couples aged 60 and older in which one partner has early-stage ADRD to examine whether each partner’s reports of daily perceived stress and positive experiences are associated with daily sleep and long-term well-being and cognitive function over 2 years. Identifying potentially modifiable mechanisms at the daily level that explain both daily and long-term health effects within couples managing early-stage ADRD will optimize timely interventions to improve the health and functioning of both partners.

PI_NAMEs: POLENICK, COURTNEY A. (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Acceleration;actigraphy;adverse outcome;Affect;aged;Aging;Alzheimer's disease related dementia;Area;Caregivers;Caring;Cellular Phone;Chronic Disease;Cognition;cognitive function;cognitive testing;Communities;Couples;Data;Data Collection;Dementia;dementia care;depressive symptoms;Ecological momentary assessment;effective intervention;experience;falls;Family;gender difference;Health;high risk;Hour;Impaired cognition;improved;improvement on sleep;Individual;individual variation;innovation;Intervention;Interview;Knowledge;late life;Life;Link;Literature;longitudinal design;member;Mental Depression;Modeling;mortality;novel;Observational Study;Outcome;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Play;preservation;Process;promote resilience;psychological distress;psychosocial resources;recruit;Reporting;Research;Rewards;Risk;risk mitigation;Role;Self Efficacy;sex;Shapes;Sleep;Sleep Disorders;sleep quality;Social support;Spouses;Stress;structured data;Surveys;Symptoms;Telephone;Testing;Time;United States;Variant;Well in self;Work;Wrist

PROJECT_TITLE: Daily Experiences Among Couples Living With Early-Stage Dementia: Implications for Daily Sleep and Long-Term Well-Being and Cognitive Function


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: NAMATI, JACQUELINE  (contact)

PROJECT_TERMS: Academia;Adoption;Algorithms;Area;Biological;Biomedical Research;Boston;Clinical;Communications Media;Communities;Computer software;Data;Dedications;Development;Education;Educational workshop;Ensure;Faculty;Fostering;Funding;Goals;graduate student;Image;Image Analysis;image processing;imaging system;Industry;industry partner;innovation;International;Internet;Knowledge;lectures;LinkedIn;meetings;Mentorship;Methods;Mission;next generation;Optics;outreach;outreach program;Peer Review;Population;Postdoctoral Fellow;programs;Publications;Research;Research Personnel;Scientist;Services;social media;Software Tools;symposium;System;Technology;Training;training opportunity;Training Programs;Translations;Travel;Twitter;undergraduate student;Universities;Visit;web site

PROJECT_TITLE: Training-Dissemination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The ability to accurately and rapidly measure extremely low levels of biomolecules is essential for diagnosing and monitoring many diseases, as well as for detecting pathogens and toxins in food and in the environment. While sufficient for certain biomarkers, the sensitivities of most existing diagnostic systems are inadequate for measuring many protein biomarkers that exist in easily accessible biofluids at concentrations much lower than the picomolar range. In this application, we propose to engineer and refine a new ultrasensitive single molecule protein analysis platform, Molecular On-bead Signal Amplification for Individual Counting (MOSAIC), that will be able to routinely measure attomolar protein concentrations and perform high-multiplex measurements, using common laboratory infrastructure.

PI_NAMEs: WALT, DAVID R. (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Abbreviations;Address;Antibodies;antigen detection;Antigens;Bacterial Antigens;Bar Codes;Binding;Biological;Biological Assay;Biological Markers;Biological Process;Biosensing Techniques;Blood;cancer biomarkers;Classification;Clinical;clinical application;Clinical Sensitivity;clinically actionable;commercialization;Complex;cost;cross reactivity;Data;Detection;detection limit;Devices;Diagnosis;diagnostic platform;Diagnostic Specificity;diagnostic value;digital;Disease;DNA amplification;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;Event;Film;Fingers;Fluorescent Dyes;Fluorescent Probes;Food;Foundations;Future;Generations;Human Resources;Image;improved;Individual;Infrastructure;instrument;instrumentation;Label;Laboratories;Licensing;lipoarabinomannan;Liquid substance;Measurement;Measures;Methods;Microscope;Modeling;Molecular;Monitor;monolayer;multiplex assay;multiplex detection;Mycobacterium tuberculosis antigens;Neurodegenerative Disorders;Pathogen detection;Patients;Performance;Play;point of care;Protein Analysis;protein biomarkers;Proteins;Research;Resource-limited setting;Role;Saliva;Sampling;Scheme;seal;Signal Transduction;single molecule;Slide;Techniques;Technology;Testing;Time;Toxin;Training;Translating;Triage;Tuberculosis;urinary;Urine;Viral Antigens;Work

PROJECT_TITLE: Simplified Single Molecule Protein Assays with Unprecedented Sensitivity

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention

ORG_CITY: CORVALLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: FITTER, NAOMI T (contact);SMART, WILLIAM D

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: active control;Assisted Living Facilities;Categories;Cognitive;Communities;community living;Data;design;design,build,test;Elements;Ensure;Environment;Evaluation;Excision;Exercise;exercise intervention;follow-up;Foundations;Goals;Health;healthy aging;human centered design;Human Resources;improved;In Situ;innovation;Instruction;interest;Intervention;Learning;Light;Measures;Mediating;member;Methods;Mind;Moderate Exercise;older adult;Older Population;Oregon;Outcome;Patient Self-Report;Phase;Physical activity;Physical Exercise;Principal Investigator;programs;prototype;Psyche structure;psychosocial;psychosocial wellbeing;Research;Resources;Rest;Robot;robot assistance;robotic system;Robotics;Skilled Nursing Facilities;skills;social;strength training;success;System;therapy design;Time;tool;treatment group;Universities;Update;Veterans;wearable sensor technology;Well in self;Work

PROJECT_TITLE: NRI: Robot-Assisted Longitudinal Physical and Cognitive Exercise Interventions for Older Veterans


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Substance use and substance use disorders, which have increasing prevalence in the US, place a huge personal, social and economic burden on society. Addressing this burden requires state-of-the-art epidemiologic research to detect and monitor trends, and to identify malleable risk factors in different populations in order to inform interventions that will reduce the toll of substance abuse on individuals and society. Since its start in 2012, the Substance Abuse Epidemiology Training Program (SAETP) at Columbia University Medical Center has been training productive, successful junior substance abuse epidemiologists; in a renewal cycle, we propose to continue such training, making the public health relevance of this program very strong.

PI_NAMEs: HASIN, DEBORAH S (contact);MARTINS, SILVIA SABOIA

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: substance abuse epidemiology;Training Programs;Universities


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Obesity is both a disease, affecting 1 in 3 Americans, and a risk factor for other chronic diseases, such as cardiovascular disease, type 2 diabetes, and 13 forms of cancers. Diet and exercise are the cornerstone of obesity prevention and treatment; however, a considerable number of individuals are non-responsive to existing weight-loss interventions and obesity rates continue to rise. Chronic (8 weeks), overnight (8 hours/night) low oxygen exposure may provide a non- conventional approach to supplement current weight-loss strategies, inform new strategies to accelerate weight loss, aid long-term weight management efforts, and benefit metabolic health in individuals with obesity.

PI_NAMEs: BERRYMAN, CLAIRE E. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acceleration;Accelerometer;Adolescent;adult obesity;Affect;Altitude;American;arm;Atmospheric Pressure;Blood;Body Composition;Body fat;Body Weight;Body Weight decreased;Calibration;Caloric Restriction;Cardiovascular Diseases;Catecholamines;Cholecystokinin;Chronic;Chronic Disease;cost;Desire for food;Diet;diet and exercise;Disease;Double-Blind Method;doubly-labeled water;Dual-Energy X-Ray Absorptiometry;Electrocardiogram;energy balance;Energy Intake;Energy Metabolism;Environment;Exercise;Expenditure;Exposure to;Fasting;feeding;food consumption;ghrelin;glucagon-like peptide 1;Health;Home;Hormones;Hour;Hunger;Hypoxia;Indirect Calorimetry;Individual;Intake;Intervention;Label;Leptin;Malignant Neoplasms;Measures;Metabolic;Methods;Modeling;natives;Non-Insulin-Dependent Diabetes Mellitus;normoxia;Obesity;obesity prevention;obesity treatment;Oregon;Outcome Study;Oxygen;Peptide YY;prospective;Psychosocial Factor;Public Health;Questionnaires;Randomized;randomized, clinical trials;remote location;response;Risk Factors;Sea;Sleep;Standardization;System;Testing;tissue oxygenation;Travel;urinary;Water;Weight;weight loss intervention;Weight maintenance regimen;Wrist

PROJECT_TITLE: Effects of daily low oxygen exposure on weight status, body composition, and metabolic health

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project narrative Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease that affects motor neurons, and recent studies with animal models of the disease identified the EphA4 receptor as a disease- modifying gene, that is, it was found to be critical for the progression of the disease. We have preliminarily obtained a novel family of EphA4 targeting agents binding to its ligand binding domain. Given the properties of the molecules and our preliminary data, we believe that these agents may be rapidly developed into a novel targeted therapy to treat ALS.

PI_NAMEs: PELLECCHIA, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Affinity;ALS patients;Amyotrophic Lateral Sclerosis;Animal Disease Models;Animal Model;Animals;aqueous;Astrocytes;Astrocytosis;Binding;Brain;C9ORF72;Cell model;Cells;Cellular Assay;Chromosome 9;Clinical Research;Clinical Trials;combinatorial chemistry;Complex;COVID-19 pandemic;Data;Degenerative Disorder;design;Development;Digit structure;Disease;Disease Progression;Dose;drug candidate;Drug Targeting;effective therapy;EphA4 Receptor;Failure;familial amyotrophic lateral sclerosis;Family;follow-up;Foundations;Genes;improved;In Vitro;in vivo;innovation;insight;Laboratories;Lead;lead optimization;Ligand Binding Domain;Ligands;Medical;Microsomes;Modeling;Motor Neuron Disease;Motor Neurons;mouse model;Mus;mutant;Mutation;Names;nanomolar;neuron loss;new therapeutic target;novel;Patients;Pediatric Hospitals;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Plasma;Property;Rattus;Research Institute;Resolution;Roentgen Rays;Role;Series;Signal Transduction;Solubility;sporadic amyotrophic lateral sclerosis;Structure;superoxide dismutase 1;targeted agent;targeted treatment;Testing;Therapeutic;therapeutically effective;Time;tool;Transgenic Organisms;Untranslated RNA

PROJECT_TITLE: Targeting the EphA4 in motor neuron disease: a structure-based approach

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The UCSD Clinical and Translational Research Institute (CTRI) will continue to support and transform clinical research by providing guidance and support from initial planning of research through data analysis and dissemination. It will provide an educational pipeline to train the next generation of clinical and translational scientists and involve the community in setting the direction and priorities of the organization. The CTRI will foster development of novel technologies that facilitate clinical research and support investigators by providing the services needed to conduct clinical research and improve health. Page 127 Project Narrative

PI_NAMEs: FIRESTEIN, GARY S (contact);HOGARTH, MICHAEL ;SMITH, DAVID MITCHELL

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Abbreviations;Acceleration;Applied Research;biobank;Bioinformatics;biomedical informatics;Biomedical Research;California;career development;Certification;Clinic;Clinical;Clinical Data;clinical data warehouse;clinical infrastructure;clinical investigation;Clinical Research;clinical trial readiness;Clinical Trials;cloud based;Collaborations;Communication;Communities;community clinic;community empowerment;community engagement;community involvement;Community Physician;Computational Biology;Creativeness;Data;Data Analyses;data dissemination;data visualization;Decision Making;Development;Devices;Discipline;Diverse Workforce;drug discovery;Ecosystem;Education;Electronic Health Record;Engineering;Fostering;Friends;Future;Goals;Grant;Health;Health protection;Health Sciences;Healthcare;Heterogeneity;Hispanic Populations;Hospitals;Human;Immunogenomics;Immunology;improved;Informatics;informatics infrastructure;informatics tool;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;Investigation;Life Cycle Stages;life span;Link;Medical;Medical center;medical schools;Medicine;Mentors;Methamphetamine;Methods;mobile application;mobile computing;Monitoring Clinical Trials;multidisciplinary;National Center for Advancing Translational Sciences;Native Americans;Neighborhood Health Center;new technology;next generation;novel;online course;outreach;Patients;Pediatric Hospitals;Peer Review;Pharmaceutical Preparations;Pharmacy facility;Phase;Process;process improvement;programs;Public Health;Public Health Schools;quality assurance;recruit;Registries;Research;Research Ethics;Research Institute;Research Methodology;Research Personnel;Research Support;Resources;Sampling;School Nursing;Schools;Science;science teacher;Scientist;Secure;Services;social media;software systems;Special Population;support tools;Testing;Training;Training and Education;Training Programs;Translating;Translational Research;translational scientist;Underrepresented Minority;underserved community;Universities;user-friendly;virtual;virtual reality game;Visualization software;Vulnerable Populations;Workforce Development;Writing

PROJECT_TITLE: UC San Diego Clinical and Translational Research Institute


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: SAN LUIS OBISPO

ORG_NAME: CALIFORNIA POLY STATE U SAN LUIS OBISPO

PHR: NIH R25 (PAR-19-215) “Team-Based Design in Biomedical Engineering Education” Narrative The proposed BiCEP program aim to integrate the clinical setting and relevant, contemporary biomedical practice in to the undergraduate curriculum and consists of two parts: i) Summer Immersion in Design Experience (SIDE) course focusing on the device design and development process and entrepreneurship in the biomedical space, and ii) a Clinical Immersion Experience (CLINEX) program that engages students with clinical mentors in a hospital setting. The goal of this is to provides a contextual bridge between students’ varied lower-division coursework and their more integrative upper-division core courses in the BMED program, ultimately leading to a more innovative and relevant educational experience. Integrating the clinical and medical context with design experiences throughout the BMED curriculum, and focusing on team-based design experiences is expected cultivate an ecosystem to support innovative projects and educate creative Biomedical Engineering professionals.

PI_NAMEs: HAWKINS, BENJAMIN GEORGE (contact);HEYLMAN, CHRISTOPHER ;WHITT, MICHAEL DAVID

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Address;Administrator;Area;base;Behavior;Biology;Biomedical Engineering;Businesses;Chemistry;Client;Clinical;Clinical Engineering;clinically relevant;Communication;Complex;Computer Models;Creativeness;design;design,build,test;Development;Device Designs;Device or Instrument Development;Discipline;Disparate;Documentation;Ecosystem;Education;education research;Educational Curriculum;Engineering;engineering design;Ensure;Entrepreneurship;Environment;Evaluation;experience;Faculty;feeding;Germination;Goals;Healthcare Industry;Hospitals;ideation;Immersion;implementation barriers;Incubated;Industrialization;Industry;innovation;Institution;interest;Investments;Knowledge;knowledge base;Legal patent;Life Cycle Stages;manufacture;Marketing;Mathematics;Measures;Medical;Medical center;Mentors;Modeling;multidisciplinary;Nurses;Outcome;Outcome Measure;Participant;peer;Phase;Physicians;Physics;portability;Privacy;Procedures;Process;Program Development;Program Evaluation;programs;prototype;Publications;responsible research conduct;scaffold;Services;simulation;skills;student participation;student training;Students;success;Training;undergraduate student;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Celiac Disease;Clinical Research;Digestive Diseases;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Primary Immunodeficiencies;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Individuals with GOF-STAT3 mutations and Down Syndrome have a forty- and five-fold greater risk, respectively, of developing Celiac Disease, while the treatment options are limited to a gluten-free diet. We hypothesize that JAK-STAT overactivation is a primary genetic cause of the predisposition to Celiac Disease. The proposed research will collect samples and clinical data from familial CeD, GOF-STAT3-CeD and DS-CeD individuals and will investigate the JAK-STAT pathway in the pathogenesis of gluten-specific CD4+ T cells. Overall, the study will provide a proof-of-concept that JAK inhibitors may be beneficial for some Celiac Disease patients with an JAK-STAT dependent signature.

PI_NAMEs: KONG, XIAO-FEI  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: adaptive immunity;Affect;Agonist;Atrophic;Autoimmune Diseases;Bioinformatics;Biological;Biological Assay;career;career development;CD4 Positive T Lymphocytes;Celiac Disease;Cellular biology;Chromosome 21;Clinical;Clinical Data;clinical investigation;clinical phenotype;clinically significant;cohort;cytokine;Cytotoxic T-Lymphocytes;Databases;design;Development;Development Plans;Disease;Down's Syndrome;Exhibits;exome sequencing;gain of function;Gastrointestinal Diseases;Gene Dosage;Gene Expression Profile;General Population;Genes;Genetic;genetic approach;Genetic Determinism;Genetic Diseases;genetic risk factor;Genetic Screening;genetic variant;Germ Lines;Gluten;Gluten-free diet;Goals;Helper-Inducer T-Lymphocyte;high risk;HLA-DQ2;HLA-DQ8 antigen;Human;Human Subject Research;IFNAR1 gene;IFNAR2 gene;IFNGR2 gene;IL10RB gene;Immune;Immunity;Immunologics;Immunology;Impairment;indexing;Individual;Inflammatory;Inherited;inhibitor;Insulin-Dependent Diabetes Mellitus;Interferon alpha;Interferon Receptor;Interferon Type II;Interferons;Interleukin-15;interleukin-21;International;intestinal villi;Investigation;Knowledge acquisition;Laboratories;Lead;Libraries;Measures;Mediating;Mentors;Molecular;Molecular Profiling;monocyte;Mutation;Pathogenesis;Pathway interactions;patient oriented;Patients;Pattern;permissiveness;Pharmaceutical Preparations;Phenocopy;Phenotype;Phosphorylation;Physicians;Predisposition;Production;Proliferating;receptor;Receptor Gene;recruit;Reporting;Research;research and development;Research Personnel;response;Risk;RNA;Role;Sampling;Scientist;screening;Serum;Severities;Signal Transduction;single-cell RNA sequencing;skills;Sorting;STAT1 gene;STAT3 gain of function;STAT3 gene;T-Cell Development;T-Lymphocyte;Testing;therapeutic target;Thyroiditis;Training;Training Programs;Transcript;transcription factor;transcriptome sequencing;Transducers;Translational Research;Work

PROJECT_TITLE: A generic and immunological investigation of JAK-STAT in the pathogenesis of Celiac

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Natural Products;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Cannabis and alcohol co-use is a major public health concern, but little is known whether specific cannabinoids, alone or in combination with initial drinking, increase or decrease alcohol risk in humans. The project will use a combination of controlled laboratory methods and mobile technology to examine the immediate influences of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on alcohol consumption in the laboratory and in real life contexts in a person’s daily life. The project will provide information critical to the development of policy, prevention, and treatment efforts to reduce the significant health and economic impact of alcohol use disorders.

PI_NAMEs: METRIK, JANE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acute;addiction;Address;alcohol abuse therapy;alcohol behavior;alcohol consequences;Alcohol consumption;alcohol craving;alcohol demand;Alcohol dependence;alcohol effect;alcohol measurement;alcohol response;alcohol risk;alcohol use disorder;Alcohols;Animal Model;Area;Cannabidiol;Cannabinoids;Cannabis;cannabis administration;cannabis use behavior;Cellular Phone;Clinical Data;Clinical Research;Consumption;contextual factors;craving;Cues;Data;design;development policy;Devices;Dose;drinking;DSM-V;Ecological momentary assessment;economic impact;Environment;Event;Health;Heavy Drinking;Human;incentive salience;indexing;Individual;Laboratories;Laboratory Study;Life;Link;Location;Marijuana;marijuana use;Measures;Medical;Medicine;Methods;mobile computing;Motivation;Near-Infrared Spectroscopy;Outcome;Participant;Persons;Pharmacodynamics;Phase;Placebos;Prevention;prospective;Psychological reinforcement;Psychotropic Drugs;Public Health;Publishing;Randomized;Recreation;Reporting;Research;Risk;Role;Science;Self Administration;Severities;Smoke;social;Testing;Tetrahydrocannabinol;Treatment outcome;United States National Institutes of Health;Work

PROJECT_TITLE: Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods


ORG_CITY: NAKHON PATHOM

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: MAHIDOL UNIVERSITY

PHR: Overall Narrative The forests and plantations of Southeast Asia form a complex and rich ecology that is home to all major malaria parasite species of public health importance. This study will use state-of-the-art tools in genetics, serology, parasitology, and vector biology to tackle current challenges confronting the malaria-elimination effort in this region, focusing on the factors underlying disease transmission and the rapid spread of Plasmodium knowlesi, a malaria parasite of monkeys that often causes severe and fatal infections in humans. The expected outputs of this project range from fundamental knowledge underlying parasite virulence and transmission to new diagnostic tools for point-of-care and surveillance applications.

PI_NAMEs: PRACHUMSRI, JETSUMON  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: accurate diagnosis;Address;Antigens;Area;Biology;Breeding;burden of illness;Chloroquine resistance;Clinical;Collaborations;combat;Communities;Complex;Country;Death Rate;design;Detection;Development;Diagnosis;Diagnostic tests;diagnostic tool;Disease;disease heterogeneity;disease transmission;Drug resistance;Ecology;effective intervention;Environment;Epidemiological trend;Epidemiology;Evolution;Exhibits;forest;Fostering;Genetic;Glean;Heterogeneity;Home;Human;Immune response;improved;Infection;Infectious Agent;Insecticide Resistance;insight;Institution;interdisciplinary approach;Interdisciplinary Study;International;international center;Intervention;Japan;Knowledge;Laboratories;Malaria;malaria transmission;Malaysia;Measures;Molecular;Molecular Biology;Monkeys;Morbidity - disease rate;Nature;novel;novel diagnostics;Outcome;Output;Parasites;Parasitology;Pathologic;Pattern;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;point of care;Policies;Population;Population Dynamics;Population Genetics;Porosity;prevent;programs;Public Health;Pyrimethamine;Rapid diagnostics;Research;Research Personnel;Research Project Grants;Resistance development;resistant Plasmodium falciparum;Resource-limited setting;Role;Sampling;Serology;Site;Southeastern Asia;Structure;success;System;Techniques;Thailand;tool;transmission process;United States;vector;vector control;Virulence;Zoonoses

PROJECT_TITLE: The changing landscape of human and zoonotic malaria in Southeast Asia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Achievement;Biology;Biometry;Collaborations;Complex;data management;design;Educational workshop;Ensure;Epidemiology;Fostering;Goals;Human;Immunology;Institution;International;international center;Japan;Malaria;malaria transmission;Malaysia;meetings;Monitor;Occupational activity of managing finances;outreach;Population Genetics;Public Health;Regulation;Research;Research Activity;Research Personnel;Scientist;Site;Southeastern Asia;Structure;success;Techniques;Thailand;timeline;Training;Travel;United States;vector;virtual;Zoonoses

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Data Science;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PI_NAMEs: KHAMSIRIWATCHARA , AMNAT  (contact)

PROJECT_TERMS: Address;archive data;Archives;biological specimen archives;Biometry;Biostatistical Methods;California;Clinical;Clinical Data;cloud based;cluster computing;Collaborations;Communities;complex data;Computer software;computerized data processing;cost;Data;data acquisition;data archive;data format;data management;Data Management Resources;data modeling;data quality;Data Science;Data Set;data sharing;data standards;Data Storage and Retrieval;Databases;deep sequencing;design;Devices;diverse data;Educational workshop;electronic data;Ensure;Faculty;FAIR principles;field study;Genomics;Human;Human Resources;Information Systems;Infrastructure;Institution;Internet;Laboratories;land cover;land use;Malaria;Malaysia;Modernization;multidisciplinary;Nature;open source;Procedures;Process;programs;Proliferating;protocol development;Public Health Informatics;Publishing;Qualifying;quality assurance;remote sensing;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Scientist;Secure;sensor;service providers;Site;Source;Southeastern Asia;Specimen;Standardization;Structure;student training;Students;success;Technology;Thailand;tool;Training;Tropical Medicine;Universities;Validation;web services;whole genome;Zoonoses

PROJECT_TITLE: Data management


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: NGUITRAGOOL, WANG  (contact)

PROJECT_TERMS: Address;Adhesions;Affect;agricultural activity;Aldehyde-Lyases;Antibodies;antigen detection;Antigens;Area;Assessment tool;Biological Assay;Case Study;Cell surface;Characteristics;Clinical;Communities;Complex;cost effective;Country;Cross-Sectional Studies;Data Set;Detection;Diagnosis;Diagnostic tests;Disease;disease transmission;Ecology;Environment;environmental change;Epidemiology;Erythrocytes;Exhibits;Exposure to;falls;Genes;Genetic;Genetic Transcription;genome-wide;Germ Cells;Health;Heterogeneity;Human;Immunity;improved;In Vitro;Incidence;indexing;Infection;infection risk;land use;Libraries;Link;Malaria;Malaria Diagnosis;malaria transmission;Malaysia;Measures;Microscopy;Molecular;Monitor;Multigene Family;Outcome;Parasites;Parasitology;Patient Isolation;Patients;Pattern;Performance;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Play;point-of-care diagnosis;Population;Predisposition;Prevalence;Prognostic Marker;programs;Properdin;protein expression;Protein Family;Proteins;Proteomics;Rapid diagnostics;Recombinant Antibody;Recombinant Proteins;remote location;Risk Factors;Role;serosurvey;Site;social;southeast Asian;Southeastern Asia;System;Testing;Thailand;tool;transcriptome sequencing;transmission process;vector;Virulence;Virulent;Vulnerable Populations;Wheat;Zoonoses

PROJECT_TITLE: Project 1 The epidemiology of complex malaria in Southeast Asia


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: ZHONG, DAIBIN  (contact)

PROJECT_TERMS: Address;Adult;Affect;agricultural activity;Agriculture;Anopheles Genus;anthropogenesis;Area;Behavior;Behavioral;Biological Assay;Biology;Bite;Breeding;Communities;Comprehension;Controlled Environment;Culicidae;Deforestation;Development;disease transmission;Ecology;environmental change;Environmental Impact;environmental intervention;Epidemiology;Evolution;Exposure to;feeding;forest;Genetic;Genetic Variation;Genetic Vectors;Genotype;Habitats;Haplotypes;Human;Human Activities;Human Bites;improved;Incidence;Information Management;Insecticide Resistance;Insecticides;Integration Host Factors;Intervention;intervention effect;Knowledge;knowledge base;land use;Link;Malaria;malaria transmission;Malaysia;man made change;Measures;Membrane;Methods;Modification;Molecular;novel;Parasites;Plasmodium;Plasmodium knowlesi;Play;Population;Population Dynamics;Population Genetics;Predisposition;pressure;Prevention;programs;Public Health;Reporting;Research;Residual state;Resistance;resistance allele;Risk;Role;Shapes;Southeastern Asia;Structure;System;TEP1 gene;Thailand;tool;transmission process;vector;vector competence;vector control;Vector Ecology;vector transmission;Zoonoses

PROJECT_TITLE: Project 2 Vector biology impact on human and zoonotic malaria transmission dynamic in Southeast Asia


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Women living in eastern and southern Africa are at high risk for HIV, but effective use of oral pre-exposure prophylaxis (PrEP) for HIV prevention in this population is low. Integrating curable sexually transmitted infection (cSTI) testing for women into African HIV programs may improve PrEP uptake and use through (1) improved identification of women at high risk for HIV acquisition and (2) increased awareness of HIV susceptibility among those diagnosed with a cSTI. This study aims to conduct a randomized trial of cSTI testing to improve PrEP uptake and use among women at high risk of HIV in Uganda, with complementary mixed methods research and mathematical modelling for program optimization.

PI_NAMEs: GRABOWSKI, MARY KATHRYN (contact)

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Africa;African;African Women;aged;AIDS prevention;arm;Awareness;Biological Markers;Case Management;Chlamydia;cisgender;Clinical;cohort;Cohort Studies;Communities;cost;Data;design;Diagnosis;Diagnostic;Diagnostic tests;Eastern Africa;effectiveness-implementation randomized trial;Eligibility Determination;Emergency Situation;Enrollment;epidemic response;Evaluation;Female;Future;global health;Gonorrhea;Health Benefit;health care settings;Health Priorities;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;implementation science;improved;Incidence;Individual;Intervention;Interview;Laboratories;Link;male;mathematical model;Methods;Modeling;neonatal morbidity;Neonatal Mortality;Network-based;novel;Oral;Outcome;Participant;pathogen;Patient Self-Report;Pharmaceutical Preparations;point of care testing;point-of-care diagnostics;Population;population based;population health;pre-exposure prophylaxis;Predisposition;Pregnant Women;prevention service;preventive intervention;primary outcome;programs;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;reproductive morbidity;Research;Research Methodology;Risk;Risk Factors;Sampling;screening;Screening procedure;Sexually Transmitted Diseases;Southern Africa;standard of care;stillbirth;Surveys;Symptoms;Syphilis;Syphilis Serodiagnosis;Testing;testing services;tool;Trichomonas;Uganda;uptake;validation studies;Woman;women's diagnosis

PROJECT_TITLE: Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control through PrEP: The IN-STEP study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE  Molecular targeted therapy has emerged as a promising approach for combating complex human diseases. Nonetheless, discovering effective, personalized small-molecule drugs presents a significant challenge. This research program aims to address this challenge by investigating transferable, cell type-specific drug response and combinatorial response models, and therefore provides valuable tools for guiding drug development efforts.

PI_NAMEs: GUAN, YUANFANG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Cell Line;Cell model;cell type;Collection;combinatorial;Complex;Data Set;drug development;drug response prediction;Effectiveness;Evolution;Goals;Heterogeneity;Human;human disease;Immune Evasion;Immune system;improved;In Vitro;large language model;Literature;Machine Learning;Modeling;molecular targeted therapies;Mutation;personalized medicine;Pharmaceutical Preparations;prediction algorithm;Process;programs;Research;response;Sampling;small molecule;System;targeted treatment;tool;tumor

PROJECT_TITLE: Machine Learning for Drug Response Prediction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative Medications to treat HIV, called antiretroviral therapy or ART, benefit individuals and society, but do not resolve all immune system problems in people with HIV infection (PWH). In this project, we will study whether one part of the immune system - the interferon-stimulated gene, or ISG, system - remains abnormal in PWH even when they are taking ART. This could help identify ways to target new treatments to reduce immune system problems that remain in PWH despite antiretroviral treatment.

PI_NAMEs: MACKELPRANG, ROMEL D (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;Affect;Aftercare;Alcohols;Animal Model;antiretroviral therapy;arm;Bioinformatics;Blood specimen;CD4 Positive T Lymphocytes;Cell Count;Chronic;chronic infection;Clinical;Communicable Diseases;comorbidity;Data;Degenerative Disorder;detection assay;detection limit;Diagnosis;Disease;Disease Progression;Drug usage;Early treatment;exhaustion;Gene Activation;Gene Expression;Genes;Health Benefit;HIV;HIV diagnosis;HIV Infections;Human;humanized mouse;Immune;immune activation;Immune response;Immune system;Immunologics;Individual;Infection;Inflammatory;Interferon Activation;interferon therapy;Interferons;Kinetics;latent HIV reservoir;Lead;Linear Models;longitudinal analysis;Measures;Mediating;mortality;Nature;nonhuman primate;novel;Outcome;Participant;Pathway interactions;Persons;Peru;Pharmaceutical Preparations;Prevalence;prevent;Primary Infection;Proviruses;Public Health;Randomized;RNA;sample archive;sample collection;Sampling;Serology;Societies;System;Testing;Therapeutic;therapy adherence;time use;transmission process;Up-Regulation;Viral;Viral Load result;Visit

PROJECT_TITLE: Longitudinal analysis of HIV reservoir and type I/III interferon system in people with HIV who initiated ART during primary infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Heart Disease;Infectious Diseases;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Due to its prevalence and synergistic, deleterious effects on overall health and quality of life, arterial stiffness and neurocognitive disorders are public health concerns in older adults living with HIV. Therefore, this proposal is relevant to public health because it seeks to determine the vascular contributions to cognition and the preliminary impact of exercise, which is in accordance with the NIA Strategic Directions for Research as it addresses the development of “effective interventions to maintain health, well-being, and function to prevent or reduce the burden of age-related diseases, disorders, and disabilities.” This project will inform targeted interventions aimed at reducing the public health burden of arterial stiffness and neurocognitive disorders to promote healthy aging with HIV, which is responsive to the NIH’s HIV Research Priorities to reduce HIV- associated comorbidities and coinfections.

PI_NAMEs: JONES, RAYMOND  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;Address;Adherence;Age;age related;Age related comorbidities;age-related disease;aged;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;arterial stiffness;aspirate;Award;Blood Vessels;Brain;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;career development;Cerebrovascular system;Clinical Trials;co-infection;Cognition;Cognitive aging;cognitive function;combat;comorbidity;Data;Dementia;design;Development;Development Plans;disability;Disease;Educational Intervention;effective intervention;efficacy evaluation;Elements;Exclusion;Exercise;exercise intensity;exercise intervention;exercise physiologist;experience;Feasibility Studies;Feedback;Future;Goals;Grant;Health;healthy aging;high risk;HIV;HIV-associated neurocognitive disorder;Impaired cognition;improved;Individual;Interval training;Intervention;Interview;K-Series Research Career Programs;Knowledge;Link;Manuals;Measures;Mentors;Mentorship;Methodology;Minority;Moderate Exercise;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;older adult;Older Population;Outcome;Participant;participant safety;Patient Self-Report;Personal Satisfaction;Persons;Pilot Projects;pilot trial;Prevalence;prevent;Prevention strategy;primary outcome;Procedures;programs;Protocols documentation;Public Health;Pulse Pressure;Qualitative Research;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research;research and development;Research Methodology;Research Personnel;Research Priority;Risk;Risk Factors;Safety;Sample Size;Scientist;secondary outcome;Secondary Prevention;skills;Stroke;Structure;tertiary prevention;Testing;Theoretical Domains framework;therapy development;Time;Training;Translational Research;trial comparing;United States National Institutes of Health;vascular contributions;Vascular Diseases;Vulnerable Populations;Workload

PROJECT_TITLE: A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults with HIV.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: MH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: This attachment is not required by FOA PA-21-071; this placeholder is just to resolve system-to-system solution errors.

PI_NAMEs: JAROME, TIMOTHY JOSEPH (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: The sex-specific role of degradation-specific protein polyubiquitination in fear memory formation

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

PHR: Project Narrative To understand the intricate gene regulatory mechanisms that operate during differentiation, comprehensive mathematical modeling of both the genome and epigenome at single-cell resolution is needed. An extension to the recent single-cell RNA velocity framework can capture and link multiple molecular layers together and help decipher detailed disease mechanisms.

PI_NAMEs: LI, CHEN  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Area;ATAC-seq;Biological;Blood Cells;Blood typing procedure;brain cell;Cell Differentiation process;Cell Reprogramming;cell type;Cells;Chromatin;Complex;computer studies;Computing Methodologies;Coupling;Data;data modalities;Data Set;Development;Differential Equation;Disease;Enhancers;Epigenetic Process;epigenome;epigenomics;Equation;experimental study;Gene Expression;Genes;Genetic Markers;Genetic study;Genetic Transcription;Genome;Genomics;Hematopoietic stem cells;Heterogeneity;HIV;HIV Infections;Human;Immune;improved;Infection;insight;Invaded;Length;Link;Macrophage;Malignant Neoplasms;Maps;mathematical model;Mathematics;Measurement;Measures;Methods;Modality;Modeling;Molecular;multimodal data;multimodality;Multiomic Data;multiple omics;Mus;Production;promoter;Regulation;Regulatory Element;Research;Research Personnel;Resolution;RNA;RNA Sequences;RNA Splicing;Sampling;Scheme;single cell technology;single-cell RNA sequencing;System;T-Lymphocyte;Techniques;Testing;Time;Transcript;transcription termination;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Single-Cell Multi-Omic Analysis of Cell Differentiation in HIV Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-J (20)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: TYLER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Project Narrative The human immunodeficiency virus (HIV) enters host cells that fight infection and uses those cells to reproduce itself, causing infected people to become vulnerable to other infections and diseases. Structural dynamics of the HIV surface protein envelope promotes HIV entering susceptible cells via membrane fusion and helps the virus evade antibodies. This research will provide valuable new insights into the time-resolved structural dynamics and allostery of the HIV envelope to better inform the design of envelope-centric interventions such as vaccines, antibody therapy, and anti-viral drugs.

PI_NAMEs: LU, MAOLIN  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Allosteric Regulation;Anti-viral Agents;Antibodies;Antibody Therapy;Artificial Intelligence enhanced;Automobile Driving;Binding;Binding Sites;Biological Assay;Bulla;CD4 Antigens;Cell membrane;Cells;Chemistry;design;Disease;env Gene Products;Equilibrium;Event;fighting;Fluorescence Resonance Energy Transfer;fluorophore;Genetic Code;Glycoproteins;Goals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV-1;Image;Immune Evasion;improved;In Situ;Individual;Infection;inhibitor;insight;Intervention;Investigation;Knowledge;Label;Length;Link;Maps;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;millisecond;minimally invasive;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;Monitor;Motion;Network-based;neutralizing antibody;novel;Outcome;Peptides;Persons;Predisposition;preference;Process;Proteins;Protomer;receptor;receptor binding;Research;Role;Sampling;Series;simulation;single-molecule FRET;Site;small molecule;spatiotemporal;Structure;Surface;System;Techniques;Testing;Time;tool;Vaccines;Viral;Virion;Virus;Visualization

PROJECT_TITLE: Probing real-time conformational dynamics and allosteric cooperativity of the HIV-1 envelope glycoprotein during virus entry

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The overarching aim of this application is to uncover molecular mechanisms by which Retinoblastoma and Hippo pathways regulate cell proliferation and differentiation during Drosophila development. This knowledge will help to advance the understanding of normal development and animal physiology and provide insights into fundamental regulatory growth mechanisms that may go awry in human disease.

PI_NAMEs: FROLOV, MAXIM  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adult;Animals;Area;Binding;Biological Models;Biological Process;Cell Cycle Regulation;Cell Differentiation process;Cell Proliferation;Cells;Chromatin;Compensation;Coupled;Development;Differentiation and Growth;Disease;Drosophila genus;Enhancers;epigenomics;Event;experimental study;Eye;Family;fly;Future;Gene Expression;Genes;genetic analysis;Genetic Transcription;Genomic approach;Goals;Growth;human disease;insight;interest;Knowledge;Malignant Neoplasms;Metabolic;Molecular;Muscle;Muscle Development;Nucleic Acid Regulatory Sequences;Organism;Orthologous Gene;Pathway interactions;Phenotype;Photoreceptors;Physiology;Process;progenitor;programs;Proteins;Research;Retinoblastoma;Retinoblastoma Genes;retinoblastoma pathway;Retinoblastoma Protein;Role;Signal Pathway;single cell genomics;Skeletal Muscle;stem cells;Tissues;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Control of cell proliferation and differentiation by growth pathways

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]