NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Rare Diseases

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: PROJECT NARRATIVE The brain White Matter (WM) and its characteristic component myelin have emerged as active participants of the brain plasticity necessary for high order functions including learning and memory; consequently, WM/myelin disruption cause multiple neurological issues and it is believed to underly neurodevelopmental conditions includ- ing Learning Disabilities (LD). To discover the links between subnormal learning and defective myelin, I use mouse models of Costello Syndrome (CS), a neurodevelopmental disease caused by mutations in a single gene (HRas), in which most patients present with LD in correlation with WM/myelin abnormalities. Preliminary results indicate that myelin defects caused by a CS mutation negatively impact the ability of mice to learn fine motor skills; therefore, this project aims to describe cellular, molecular, and brain connectivity abnormalities underlying subnormal learning.

PI_NAMEs: LOPEZ JUAREZ, ALEJANDRO  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior test;Behavioral;Biology;Brain;brain dysfunction;Brain imaging;brain volume;Cell Proliferation;Cells;Characteristics;Chronic;Clinical;Collaborations;Communication;Complex;Costello syndrome;Data;Defect;design;Development;Disease;Dose;Drug Targeting;Drug usage;Electrophysiology (science);epigenomics;Female;Foundations;Functional disorder;Funding;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genotype;Germ Lines;Germ-Line Mutation;Goals;Hyperactivity;Image;Impairment;in vivo;innovation;Learning;Learning Disabilities;Link;Magnetic Resonance Imaging;Maintenance;male;MAP Kinase Gene;Memory;Mendelian disorder;Mentors;Modification;Molecular;motor impairment;motor skill learning;Motor Skills;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myelin;myelination;Neurodevelopmental Disorder;Neuroglia;Neurologic;Neurons;neurotransmission;Nitric Oxide;NOS1 gene;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Participant;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;precursor cell;Predisposition;Process;Production;Productivity;programs;Research;Research Personnel;Rodent;Role;Running;Schedule;Scheme;Scientist;Secure;Shapes;Signal Pathway;Signal Transduction;Solid;stem cells;Structure;Symptoms;System;Testing;therapy development;Time;Training;United States National Institutes of Health;white matter

PROJECT_TITLE: Defining the Disease-Causing HRasG12V Mutation as a Link for Defective Myelin and Subnormal Learning


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Childhood Injury;Estrogen;Heart Disease;Neurosciences;Pediatric;Rehabilitation;Women's Health Research

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Cardiac arrest is an important cause of mortality and poor neurological outcome in children, with approximately 16,000 arrests occurring each year in the US. Unfortunately, there are currently no drugs available in the United States to improve outcome and quality of life following cardiac arrest in children. The proposed studies will characterize the response of childhood brain to cardiac arrest and demonstrate that puberty provides insights into enhanced recovery observed in children compared to adults.

PI_NAMEs: HERSON, PACO S (contact);QUILLINAN, NIDIA

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Adolescent;Adult;Age;age group;Agonist;Androgen Receptor;Androgens;antagonist;Award;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Cardiopulmonary Resuscitation;Cell Death;Cell model;Child;Childhood;Cognitive deficits;Data;ESR1 gene;Estrogen Receptors;Estrogens;Exhibits;Exposure to;Female;Foundations;Functional impairment;functional outcomes;Gene Expression;Genetic;Gonadal Steroid Hormones;Grant;Heart Arrest;Hippocampus;Hormonal;Hormones;Impairment;improved;improved outcome;Injury;insight;Intervention;Ischemic Neuronal Injury;Knock-out;Laboratories;Learning;Long-Term Potentiation;male;Mediating;Memory;Memory impairment;Modeling;mortality;Mus;Neurological outcome;neurorestoration;novel;Outcome;parent grant;Patients;Pharmaceutical Preparations;Pharmacology;Physiological;Population;prevent;Puberty;Publishing;Quality of life;receptor;Receptor Signaling;Recovery;Recovery of Function;Regulation;Research;response;Role;sex;Sex Differences;Signal Transduction;Steroids;Stimulus;synaptic function;Synaptic plasticity;synaptogenesis;targeted treatment;Testing;Testosterone;Therapeutic;United States

PROJECT_TITLE: Sex differences in brain injury following pediatric cardiac arrest


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This project will examine the effects of a large-scale poverty reduction program on health risk among older and younger adults in rural Malawi. It extends a longitudinal randomized control trial of a national cash transfer program and integrates new measures of infection, diseases and cognitive capacity to identify the biological and behavioral pathways through which poverty affects health and mortality risk. Results will contribute to knowledge on the structural, biological and behavioral pathways that affect healthy well-being at two points in the life-cycle, with implications for public policies designed to address the multi-faceted consequences of poverty.

PI_NAMEs: HANDA, SUDHANSHU  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: 19 year old;Address;Adolescence;Adult;Affect;Africa;Age;Aging;aging process;Alcohol consumption;alcohol risk;Behavioral;beneficiary;Biological;Biological Markers;Blood;Child Health;Chronic Disease;Chronic stress;cognitive capacity;cohort;Control Groups;Country;Data;Data Set;design;Disease;Disease susceptibility;disorder risk;Dryness;Economics;Elderly;Evaluation;experience;Explosion;Exposure to;Female;Goals;Government;Health;healthy aging;Household;Hypertension;immune function;immune health;Immune response;Immune system;Immune System Diseases;Immunologic Tests;Income;Infection;Inflammation;Intervention;Interview;Kenya;Knowledge;late life;Life;Life Cycle Stages;Link;low and middle-income countries;Low income;Malawi;Maps;Measures;Mediating;member;Memory;Mental Health;middle age;mortality risk;National Institute on Aging;older adult;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Physiological;post intervention;Poverty;poverty alleviation;poverty reduction;preference;programs;psychologic;Psychosocial Stress;Public Policy;Questionnaires;Randomized;Randomized, Controlled Trials;Research;Respondent;Risk;Role;Rural;Sampling;Sampling Studies;satisfaction;Schools;social;Societal Factors;Spottings;Stress;study population;Surveys;Testing;Time;transition to adulthood;trial design;Vulnerable Populations;World Bank;young adult

PROJECT_TITLE: The effect of poverty, stress and immune function on health across the life-course

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Rehabilitation

ORG_CITY: FAIRFAX

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: Public Health Significance Currently, there are approximately 50,000 individuals living with upper limb loss in the US. Upper extremity amputations most commonly occur in working age adults as a result of trauma, and frequently affect the dominant extremity, leading to significant impacts on activities of daily living. Despite the enormous investment of resources in the development of new multi-articulated upper limb prosthetics, a large proportion (35-45%) of upper extremity amputees discontinue use of their prosthesis, mainly due to limited functionality and usability, and there is a significant unmet need to develop better technological solutions to improve function.

PI_NAMEs: KALIKI, RAHUL REDDY;SIKDAR, SIDDHARTHA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Age;Algorithms;Amputation;Amputees;arm;Articulation;Biomedical Engineering;Biomedical Technology;Classification;Clinic;Clinical;clinical outcome measures;Clinical Research;Collaborations;comparison control;Complex;Data;Development;Devices;Diagnostic;Electrodes;Electromyography;Evaluation;Extensor;first-in-human;Flexor;Forearm;Freedom;functional improvement;gaze;grasp;Hospitals;Image;Image Analysis;imaging modality;Implant;improved;Individual;innovation;instrumentation;Intention;Intuition;Investments;Joints;Laboratories;Laboratory Study;Laws;limb loss;Limb Prosthesis;Limb structure;Mechanics;Methods;Motor;motor control;Movement;multidisciplinary;Muscle;muscle reinnervation;myoelectric control;Myoelectric prosthesis;non-invasive system;novel;novel strategies;Outcome;Outcome Measure;Pattern Recognition;Pattern Recognition Systems;Performance;portability;Positioning Attribute;primary outcome;programs;Prosthesis;prosthesis control;prosthetic hand;prosthetic socket;prototype;Public Health;Radial;real-time images;Rehabilitation therapy;Research;Research Personnel;Residual state;Resolution;Resources;secondary outcome;sensor;Signal Transduction;spatiotemporal;Specificity;Spectrometry;Surface;System;Systems Integration;Technology;Testing;Time;Training;Transducers;transradial amputee;Trauma;Ultrasonography;ultrasound;United States;Universities;Upper Extremity;usability;virtual environment;virtual reality;wearable device

PROJECT_TITLE: Sonomyographic Upper Limb Prosthetics: A New Paradigm


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAN RAMON

ORG_NAME: SILICON KIDNEY, LLC

ORG_STATE: CA

PHR: Project Narrative Over 100,000 Acute Kidney Injury (AKI) patients receive continuous renal replacement therapy in the US each year. We are developing a new blood filter with that will operate for at least seven days without anticoagulation. The use of the new blood filter will improve AKI patient outcomes while reducing the complexity, costs, and complications associated with continuous renal replacement therapy with anticoagulation therapy.

PI_NAMEs: BLAHA, CHARLES  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Albumins;Animal Model;Anticoagulants;Anticoagulation;Area;biomaterial compatibility;Blood;blood filter;Blood flow;Citrates;Clinical;Clinical Research;Clinical Trials;Coagulation Process;commercialization;Complex;cost;Critical Illness;design;Devices;Dose;Fiber;Film;Future;hemocompatibility;Hemodialysis;hemodynamics;Hemolysis;Hemorrhage;Heparin;heparin-induced thrombocytopenia;Hour;hypoperfusion;Implant;improved;In Vitro;Intensive Care Units;International;Kidney;Legal patent;Length;Liquid substance;Marketing;Mechanics;Membrane;nanopore;Notification;Patient Admission;Patient-Focused Outcomes;Patients;Permeability;Phase;Polymers;porcine model;pre-clinical;Preparation;prototype;Renal Replacement Therapy;research clinical testing;Risk;Risk Reduction;Sepsis;Silicon;Small Business Innovation Research Grant;Sterilization;Surface;Surveys;System;Techniques;Technology;Testing;Thinness;Toxin;Urea;Uremia;Validation;Work

PROJECT_TITLE: A silicon nanopore membrane blood filter enabling anticoagulant free continuous renal replacement therapy for acute kidney injury


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The collective migration of epithelial cells plays key roles in tissue morphogenesis, intestinal turnover, wound repair, and metastasis. For an epithelium to migrate, the cell migration machinery that powers each cell’s movement must become aligned across the tissue. The goal of this research is to use the genetic tractability of fruit flies to determine :(1) how epithelial cells become organized for collective motility, and (2) how this motility can be harnessed to structure extracellular matrix over which the cells migrate.

PI_NAMEs: HORNE-BADOVINAC, SALLY  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Alveolus;Basement membrane;Bulla;Cell Communication;cell motility;Cells;Cues;Defect;Drosophila genus;Epithelial Cells;Epithelium;Extracellular Matrix;Extracellular Structure;Funding;Genetic;Geometry;Goals;Human;Individual;insight;Intestines;Kidney Diseases;Learning;mammary;mechanical force;Mediating;membrane assembly;migration;Modeling;Molecular;Morphogenesis;Motility;Movement;Muscular Dystrophies;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;Organ;organ growth;Organoids;Play;Process;programs;Protein Secretion;Proteins;Research;Role;Rotation;self organization;Shapes;Signal Transduction;Skin;Stroke;Structure;Surface;System;Tissues;Work;wound healing

PROJECT_TITLE: Mechanisms of epithelial migration and basement membrane assembly

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Binocular vision impairments are generally associated with a number of functional deficits that can severely impact the quality of life of the patients in their everyday life, affecting simple yet fundamental everyday actions like walking, grasping an object or reading and also adversely impact socio-economic opportunities. The proposed study is basic science research into the mechanisms of sensory and motor binocular vision impairment and is relevant to Public Health for three primary reasons: 1) it aims to provide a proof of concept for translating eye tracking and 3D stereo technology into the clinical practice related to binocular visual dysfunction including oculomotor deficits (such as strabismus and vergence insufficiency) and perceptual deficits (such as amblyopia, diplopia, stereo blindness and suppression); 2) it seeks to develop effective quantitative methodologies for the measurement of binocular impairments, both with synthetic stimuli and in natural environments and to quantify the distribution of depth information across the visual field in healthy and impaired visual systems; and 3) it seeks to develop the evidence base for non-invasive rehabilitation for binocular eye alignment disorders, with the aim of preventing the development and progression of binocular visual dysfunction and, when intervention is required, to augment existing therapies with rehabilitation to assist in the maintenance of binocular oculomotor control.

PI_NAMEs: BEX, PETER JOHN (contact);HUNTER, DAVID G;SABATINI, SILVIO PAOLO

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Agreement;Amblyopia;Asthenopia;Attention;Basic Science;Behavior;Behavioral;Binocular Vision;Blindness;clinical practice;Clutterings;commercialization;Complex;computer framework;critical period;Custom;Data;Depth Perception;Development;Devices;digital;Diplopia;Disease;Disparity;Education;Effectiveness;Environment;Esotropia;Evaluation;evidence base;Exotropia;Eye;Eye Movements;Failure;Feedback;Foundations;Gait;gaze;Goals;grasp;Head;Head Movements;Health;Image;Impairment;improved;innovation;Intervention;Laboratories;Life;Maintenance;Measurement;Measures;Methodology;Methods;Monitor;monocular;Monocular Vision;Motor;motor control;motor deficit;motor impairment;motor rehabilitation;movie;novel;Occupations;oculomotor;oculomotor behavior;Operative Surgical Procedures;Outcome;Patients;Perception;Performance;personalized medicine;Persons;Posture;preservation;Prevalence;prevent;Psychophysics;Public Health;Quality of life;Reading;recidivism;Rehabilitation therapy;remediation;Research;Retina;Risk;sample fixation;Sensorimotor functions;Sensory;Sensory impairment;sensory input;sensory mechanism;sensory system;side effect;socioeconomics;Sports;standard care;statistics;stereoscopic;Stimulus;Stimulus Deprivation-Induced Amblyopia;Strabismus;Structure;success;Syndrome;synergism;System;targeted treatment;Technology;Therapeutic;Time;Training;Translating;treatment response;virtual;virtual reality;Vision;Visual;visual dysfunction;Visual Fields;Visual impairment;visual performance;Visual System;visual tracking;Walking

PROJECT_TITLE: ARBi - Assessment and Rehabilitation of Binocular Sensorimotor Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SMN-B(90)S]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: abundance of genome sequence data, dissecting how genetic variation controls phenotypic diversity and disease predisposition remains challenging. This study employs high-throughput genome editing and phenotyping assays to uncover functional genetic variants across a panel of genetically and ecologically diverse wild isolates of budding yeast. This work will identify functional variants and how they interact with each other, the environment and genetic background, to give rise to complex multigenic traits.

PI_NAMEs: STEINMETZ, LARS M (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Agar;Alleles;Azoles;Bar Codes;Biological Assay;Biology;Carbon;causal variant;Cells;Chemicals;Cisplatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collection;Communities;Complex;Data;Data Set;Dependence;design;Development;Disease;Engineering;Environment;Eukaryota;Exhibits;fitness;follow-up;Foundations;functional genomics;Genes;Genetic;genetic architecture;genetic resource;genetic variant;Genetic Variation;Genome;genome database;genome editing;Genome engineering;genome sequencing;Genotype;Geography;Goals;Growth;Human Cell Line;human disease;indexing;Individual;insight;internal control;Intervention;Investigation;Libraries;Life;Life Style;Link;Liquid substance;loss of function;Measures;Metals;Methotrexate;Microbe;Minor;Modeling;Molecular;Nature;next generation sequencing;Open Reading Frames;Organism;pathogenic fungus;Pathway interactions;Phenotype;Population;precision medicine;predictive modeling;Predisposition;premature;Quality Control;recombinase;Recovery;Robotics;Saccharomyces;Saccharomyces cerevisiae;Saccharomycetales;Sirolimus;small molecule;Source;Spottings;Stress;System;Technology;Terminator Codon;Testing;Time;trait;Validation;Variant;Work;Yeasts

PROJECT_TITLE: EDGE CMT: Dissecting complex traits in wild isolates of yeast by high-throughput genome editing


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Natural Products;Pain Research;Patient Safety;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Older adults are currently the fastest growing group of cannabis users in the U.S, and they are more likely to use cannabis for medicinal purposes (e.g., pain, trouble sleeping, depression/anxiety) than for recreational purposes, despite having little data to guide their decisions about what type of product to use. This project will utilize a patient-centered observational design to recruit and assess older adults who are interested in using cannabis compared to a control group who is not interested in cannabis use. We will gather data on both the beneficial and harmful effects of edible cannabis of varying composition (THC-only vs. CBD-only vs. THC+CBD), and will examine the process by which older adult cannabis users decide what type of cannabis product they prefer.

PI_NAMEs: BRYAN, ANGELA  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Accounting;Acute;Adult;Age;age group;aged;Aging;aging population;American;Anxiety;Applications Grants;Area;Behavioral;Benefits and Risks;Blood;Cannabidiol;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;cognitive function;Colorado;comparison group;Control Groups;Data;Decision Aid;Decision Making;design;epidemiologic data;Epidemiology;Exercise;experience;Goals;Harm Reduction;Human;human old age (65+);impression;innovation;interest;Laboratories;Legal;Life;marijuana legalization;marijuana use;marijuana user;Medical;Medical Marijuana;Mental Depression;Motor;motor control;negative affect;Neurocognition;Neurocognitive;older adult;Older Population;Outcome;Pain;Participant;patient oriented;Patient Self-Report;Patients;pharmacologic;Pharmacology;Physiology;Play;Population;Prevalence;Process;prospective;Public Health;Publishing;Qualitative Methods;Quality of life;Recreation;recruit;Reporting;Research;Research Infrastructure;Risk;Role;Schedule;Sleep;Sleeplessness;Surveys;Symptom Burden;symptomatic improvement;Symptoms;Tetrahydrocannabinol;Time;virtual;Work

PROJECT_TITLE: Cannabis use among older adults: Potential risks and benefits to an aging population

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Undergraduate research experience improves retention of underrepresented students in STEM disciplines, but most research programs target undergraduates in their sophomore year, leaving a group of students who do not want research experiences until later in their training with few options. The Building Research Independence by Developing Goals and Hands-on Experiences (BRIDGE) program addresses this barrier by providing paid summer research experience, professional development opportunities, and mentoring to underrepresented students with no prior research experience going into their senior year. Importantly, the BRIDGE program will increase diversity in biomedical fields.

PI_NAMEs: BRIAND, LISA A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Active Learning;Address;Affect;Cancer Education Grant Program;career;career networking;career preparation;Coffee;college;Color;Communication;Communities;Compensation;Dedications;Development;doctoral student;Education;Educational workshop;Event;experience;Extravasation;Faculty;falls;Funding;Goals;graduate school;graduate student;Grant;Guidelines;hands on research;Hybrids;improved;Individual;interest;Laboratories;Laboratory Research;lectures;meetings;member;Mentors;Mind;Neurosciences;Not Hispanic or Latino;Occupations;Pear;peer coaching;peer networks;posters;Process;programs;Psychology;recruit;Research;Research Design;Research Personnel;responsible research conduct;Science;skill acquisition;Societies;Staff Development;STEM career;STEM field;student mentoring;student retention;Student Selections;Students;success;summer research;Surveys;symposium;Time;tool;Training;transfer student;Translating;Travel;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Vocational Guidance;Work

PROJECT_TITLE: The Building Research Independence by Developing Goals and Hands-on Experiences (BRIDGE) Program


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative DIPG is one of the most lethal pediatric brain cancers, affecting children aged 5-9 yrs old, without a current cure or significant improvement in the efficacy of treatment over the past 3+ decades. With the promise of improving quality of life, improving the safety of radiation, or increasing length of survival for children with DIPG, nanoparticle-enhanced radiation therapy first requires validation in a pre-clinical DIPG model, and additional mechanistic investigation. The included project proposal is focused on the pre-clinical development and refinement of this technique.

PI_NAMEs: CHIARELLI, PETER  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 3-Dimensional;Affect;aged;Alternative Therapies;animal imaging;Animal Model;Biochemical;Biocompatible Materials;Biological;Biological Assay;Biological Sciences;biological systems;Biology;biomaterial compatibility;Brain;Brain Diseases;Brain Neoplasms;Brain Stem;Brain Stem Neoplasms;career development;cell killing;Cells;Cellular biology;Characteristics;chemotherapy;Child;Childhood;Childhood Brain Stem Neoplasm;Childhood Malignant Brain Tumor;Chlorotoxin;Clinical;clinical translation;Clinical Trials;Coculture Techniques;Comet Assay;Convection;cytotoxicity;Data;Deposition;design;Development;Development Plans;Diffuse intrinsic pontine glioma;DNA;Doctor of Philosophy;Dose;Dose Fractionation;electron energy;ethylene glycol;Evaluation;Excision;Film;Flow Cytometry;fractionated radiation;Funding;Gamma-H2AX;Glioblastoma;Glioma;Goals;H2AFX gene;Histology;Home;Homing;human disease;Immunohistochemistry;improved;In Vitro;in vivo;Injury;Institution;interest;Intravenous;Investigation;Iron;iron oxide;iron oxide nanoparticle;irradiation;K-Series Research Career Programs;Knowledge;Length;live cell imaging;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant neoplasm of brain;materials science;Mediating;meetings;Mentors;Mentorship;Methods;Microbiology;Microscopy;Modeling;Modernization;Molecular Biology;mouse model;multidisciplinary;Mus;nanoparticle;neoplastic cell;neuro-oncology;neurosurgery;new technology;novel;novel therapeutic intervention;Nucleosome Core Particle;Oncology;Operative Surgical Procedures;Outcome;Pediatric Neoplasm;Phosphorylation;Photons;Physical Chemistry;Pontine structure;pre-clinical;preclinical development;Proteins;Publications;Quality of life;quantitative imaging;Radiation;Radiation Accidents;Radiation Dose Unit;radiation effect;Radiation Induced DNA Damage;Radiation Physics;Radiation therapy;Radiobiology;Recurrence;Regimen;Research;Research Personnel;Research Project Grants;Resected;Resources;Safety;Scientist;side effect;stem-like cell;Stromal Cells;submicron;success;Supratentorial;Surface;Survival Analysis;Techniques;Technology;Testing;Therapeutic;Thick;Thinness;tissue/cell culture;Tissues;Training;Translating;translation to humans;translational applications;treatment effect;Treatment Efficacy;tumor;Tumor Biology;two-dimensional;Validation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Nanoparticle-Enhanced Radiation Therapy for DIPG

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Healthy aging is associated with a striking paradox: As adults age, they typically have better control over their emotions while also simultaneously experiencing decline in cognitive functions and brain systems that have been associated with emotion regulation. This study will investigate the brain basis of emotion regulation in middle- and older-age adults, and how a history of depression might impact the typical pattern of age-related improvement in emotional control. Ultimately, the proposed research will help to improve quality of life for healthy older adults, while also providing treatment targets to prevent recurrence of depression for those with a depression history.

PI_NAMEs: ENGLISH, TAMMY  (contact);THOMPSON, RENEE J

PROJECT_TERMS: Address;Adult;Affective;Age;age effect;age related;age related changes;age related decline;Behavior assessment;Behavioral;Brain;Cicatrix;Code;Cognitive;cognitive control;cognitive function;cognitive reappraisal;Cues;Data;Data Set;Decision Making;Depressed mood;design;Development;Diagnostic;Dimensions;Disease remission;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional experience;emotional functioning;Emotions;Ethnic Origin;Exhibits;experience;Facial Expression;Foundations;Functional Magnetic Resonance Imaging;Goals;healthy aging;human old age (65+);Image;improved;Incentives;Individual;Individual Differences;individual variation;Influentials;innovation;insight;Intervention;Interview;Knowledge;Laboratories;Lateral;Learning;Life;Maintenance;Major Depressive Disorder;Matched Group;Measures;Mediating;meetings;Mental Depression;Mental disorders;Mental Health;Methods;middle age;Modeling;Motivation;neural;neural circuit;Neurobiology;neuroeconomics;neuroimaging;neuromechanism;normal aging;novel;Nucleus Accumbens;older adult;Participant;pathological aging;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Play;Population;positive emotional state;Prefrontal Cortex;prevent;Process;Protocols documentation;Quality of life;racial diversity;Recording of previous events;recurrent depression;Research;response;reward processing;Rewards;Role;Sampling;Scanning;Self-control as a personality trait;side effect;Source;Standardization;success;System;Testing;therapeutic target;trait;Update;Variant;Ventral Striatum;Woman;Work

PROJECT_TITLE: Neural and motivational mechanisms of age-related change in emotion regulation

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The University of Washington Developmental AIDS Research Center for Mental Health, based in Seattle, catalyzes new mental health and HIV research and develops new research leaders across the multidisciplinary spectrum of clinical, epidemiologic, statistical, behavioral, and implementation science expertise necessary to bend the curve of the global HIV epidemic. Our team blends expertise in HIV prevention, care and treatment, management of complex patients with HIV and co-morbidities, models of mental health care delivery in primary care, user-centered design for effective deployment of evidence-based psychological interventions in diverse care settings, care for co-morbid traumatic stress and substance use disorders, management of co-occurring mental disorders and other medical conditions, and rigorous quantitative methods for social science research. We bring experience in the conduct of impactful research with partners in regional and global HIV care settings and through the work of our four Cores we aim to catalyze and support innovative and impactful research to curb the HIV epidemic, with a focus on integrated intervention strategies that address HIV and mental disorders.

PI_NAMEs: GRAHAM, SUSAN MARIE (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;antiretroviral therapy;Applied Research;Behavioral Sciences;Caring;Clinical;collaborative care;Communities;community engagement;comorbidity;Complex;Consultations;Country;County;Development;Discrimination;disparity reduction;Dissemination and Implementation;driving force;effective therapy;Epidemic;Epidemiology;evidence base;experience;Geography;Goals;health care delivery;Healthcare;High Prevalence;HIV;HIV risk;implementation science;Incidence;Inequity;Infrastructure;innovation;Institution;integrated care;Intervention;Leadership;Learning;marginalized population;Measurement;Medical;Mental association;Mental Depression;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Mentorship;Methods;Mission;Modeling;mortality;multidisciplinary;next generation;novel;Pathway interactions;Patients;person centered;Persons;Populations at Risk;Poverty;Practice based research;Prevention;Prevention strategy;Primary Care;Process;Provider;psychologic;Research;Research Design;Research Personnel;Research Support;Resources;Risk;scale up;Science;Services;social science research;social stigma;socioeconomic disadvantage;Statistical Methods;Strategic Planning;Substance abuse problem;Substance Use Disorder;Symptoms;Technology;Testing;theories;therapy development;Training;Training Programs;Trauma;traumatic stress;treatment strategy;Underrepresented Populations;United States;Universities;user centered design;Vulnerable Populations;Washington;Work

PROJECT_TITLE: University of Washington Developmental AIDS Research Center for Mental Health (UW ARCH)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Patient Safety;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Breast cancer patients undergoing trastuzumab treatment are at risk of heart function decline or heart failure symptoms, but it is unknown if, when, and for how long cardiovascular protective strategies, e.g. with a beta- blocker, could help. This study randomly assigns those taking curative-intent trastuzumab to the beta-blocker carvedilol—either when significant heart function decline or subtle early signs of heart injury (either by elevation of a cardiac blood biomarker, i.e. cardiac troponin, or by an abnormal heart ultrasound marker, i.e. global longitudinal strain) are noted, or preventatively before beginning trastuzumab therapy. This study will further randomly assign those patients on carvedilol to either discontinuation at the end of trastuzumab therapy or continuation for another year, providing much needed clinical trial data on what the best strategy (“tactic”) for those at risk of cardiotoxicity with trastuzumab therapy is.

PI_NAMEs: HERRMANN, JOERG  (contact);RUDDY, KATHRYN JEAN

PROGRAM_OFFICER_NAME: DIMOND, EILEEN

PROJECT_TERMS: active method;Address;Adjuvant;Adrenergic beta-Antagonists;Adult;Anthracycline;Biological Markers;Blood;Breast Cancer Patient;Breast Cancer Treatment;Cardiac;Cardiomyopathies;cardioprotection;Cardiotoxicity;cardiovascular risk factor;Cardiovascular system;Caring;carvedilol;Clinic;clinical care;Clinical Trials;cohort;Data;Development;Drops;Epidermal Growth Factor Receptor;experience;Genetic;Genetic Predisposition to Disease;genetic variant;Heart Abnormalities;Heart failure;heart function;Heart Injuries;high risk;Human;improved;Incidence;Injury;Intervention;Lead;Left Ventricular Ejection Fraction;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Monoclonal Antibodies;mortality;Myocardial dysfunction;Outcome;Outcome Measure;patient population;Patient-Focused Outcomes;Patients;Pharmacogenomics;Preventive;Primary Prevention;Prognosis;Publishing;Randomized;randomized, clinical trials;Records;Recovery;Recovery of Function;response;Risk;Role;side effect;Specific qualifier value;Symptoms;targeted treatment;Testing;Therapeutic Intervention;therapy duration;Time;Trastuzumab;treatment arm;treatment duration;treatment response;Troponin;ultrasound

PROJECT_TITLE: TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: SIMONI, JANE M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advertising;Attention;Award;Budgets;Collaborations;Communication;Communities;Community Actions;community partners;Compensation;Databases;Decision Making;Development;digital technology;Discipline;Educational workshop;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Faculty;flexibility;Fostering;Funding;Funding Opportunities;Goals;Government;Guidelines;Health;health administration;HIV;Human Resources;Individual;innovation;Institution;International;Leadership;meetings;member;mental health center;Mission;Modification;Monitor;multidisciplinary;Multimedia;Needs Assessment;Newsletter;next generation;novel;operation;Outcome;outreach;Personnel Management;Policies;Positioning Attribute;Preparation;Procedures;programs;Progress Reports;Publishing;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Resources;response;Scanning;Science;Scientific Advances and Accomplishments;service gap;Services;Site Visit;social media;Social Network;State Government;Strategic Planning;Strategic vision;Surveys;symposium;System;timeline;Training;Travel;trend;Twitter;Universities;Update;Vision;Washington;web site;Writing

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Optic neuropathies due to heritable diseases, glaucoma, trauma or inflammation are a major cause of blindness in humans, but no effective treatments exist for the vision impairment that occurs with them. The goal of this project is to advance the speed and efficiency of research to improve retinal ganglion cell function, the cells damaged with these diseases, by developing a new nonhuman primate model of autosomal dominant optic neuropathy. This new and better animal model will speed the development and testing of innovative therapies by our team and others that will reduce the morbidity caused by optic neuropathies in humans.

PI_NAMEs: THOMASY, SARA MICHELLE (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;achromatopsia;Affect;Age;Anatomy;Animal Model;Animals;Apoptosis;Autosomal Dominant Optic Atrophy;autosome;Axon;Behavioral;Blindness;Breeding;Cell Density;cell injury;Cell Nucleus;Cell Physiology;Cellular Structures;Characteristics;Clinical;cohort;Color Visions;Communities;Contralateral;Data;Dendrites;density;Development;differential expression;Disease;disease model;Disease Progression;Drug Kinetics;Dynamin;dyschromatopsia;effective therapy;Electroretinography;Euthanasia;Exhibits;Eye;Flavoproteins;Fluorescence;Functional disorder;Future;Gene Mutation;Genes;Genetic;Glaucoma;Goals;Heritability;Heterozygote;Histologic;Homozygote;Human;human tissue;Immunohistochemistry;improved;Individual;Inflammation;Inherited;Innovative Therapy;Macaca;Macaca mulatta;macula;Measures;Missense Mutation;Mitochondria;Modeling;Monitor;Morbidity - disease rate;Morphology;mouse model;mRNA Expression;Multimodal Imaging;multiple omics;Mutation;Nerve;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;new therapeutic target;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Optic atrophy 1;Optic Disk;Optic Nerve;optic nerve disorder;optical imaging;Oxidative Stress;Pallor;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Persons;Phenotype;Physiology;Production;programs;protein expression;Protein Isoforms;Proteins;Research;Resolution;Resources;Retina;Retinal Cone;Retinal Ganglion Cells;retinal imaging;retinal nerve fiber layer;Scotoma;sight restoration;Signal Transduction;Speed;Testing;therapeutic evaluation;therapy development;Thick;Thinness;Time;transcriptome;transcriptomics;Trauma;Vision;vision science;Visual;Visual Acuity;Visual impairment

PROJECT_TITLE: Advancing novel therapies for optic neuropathy with a nonhuman primate model

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: RAO, DEEPA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;African;African American;AIDS prevention;Award;Behavioral;Behavioral Research;career development;Clinical Research;Clinical Trials Network;cohort;Communities;Community Networks;comorbidity;Competence;Data;Development;E-learning;Educational Curriculum;effective intervention;Environment;Epidemic;experience;Fellowship Program;Funding;gender diverse;graduate school;Grant;High Prevalence;HIV;HIV Vaccine Trials Network;HIV/AIDS;implementation science;improved;Individual;innovation;Institution;integrated care;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investments;Joints;Knowledge;Latinx;Lead;learning strategy;Manuscripts;marginalized population;medication compliance;meetings;member;Mental association;Mental disorders;Mental Health;mental health center;Mental Health Services;mental training;Mentors;Mentorship;Methodology;Methods;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;Outcome;peer;Persons;Primary Care;Program Sustainability;programs;Publications;recruit;Research;Research Personnel;response;scale up;Scholars Program;Science;Series;Services;skills;Standardization;System;Time;Training;Training and Infrastructure;Travel;unconscious bias;Underrepresented Populations;United Nations;United States National Institutes of Health;Universities;Vision;Washington;Work;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Many biomedical researchers use high-throughput DNA sequencing to study human disease and biology, and to do so they rely heavily on the human genome sequence and its annotated genes. The analysis of these very large, complex sequence data sets requires highly sophisticated, efficient software that can assemble DNA fragments to reconstruct a genome or assemble RNA sequences to identify genes and gene isoforms. This project will develop new algorithms, software, and data that will provide researchers with the necessary tools to address relevant biological questions in humans and a wide range of other species.

PI_NAMEs: SALZBERG, STEVEN L. (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Adopted;Agreement;Algorithms;annotation  system;Area;Biological;Biology;Biomedical Research;Catalogs;cell type;Child;Community Participation;Complex;Computer software;Computing Methodologies;cost;Data;Data Set;Databases;Development;Diploidy;DNA;experimental study;Explosion;Funding;Future;gene discovery;Gene Expression;Gene Structure;Genes;Genetic;Genome;genome annotation;genome sequencing;Genomics;Genotype-Tissue Expression Project;Haplotypes;High-Throughput DNA Sequencing;Human;Human Biology;human disease;Human Genetics;Human Genome;human reference genome;Hybrids;improved;Individual;instrument;Length;Maps;Medicine;Memory;Methods;molecular sequence database;nanopore;next generation;novel;open source;Parents;Peer Review;Population;Process;programs;Protein Isoforms;Publications;reference genome;Reproducibility;Research Personnel;Resources;RNA;RNA Sequences;RNA Splicing;Running;single molecule;software development;Source;Source Code;Speed;success;System;Techniques;Technology;Time;tool;Transcript;transcriptome;transcriptome sequencing;Variant;Vertebral column;whole genome;Work

PROJECT_TITLE: Computational Methods for Genome Assembly, Transcript Assembly, and Gene Discovery

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Atherosclerosis is a disease in which plaques with inflammatory cells accumulate in arteries. People at risk for heart attacks only partially benefit from current treatments to prevent the clinical events these plaques cause. To effectively reverse plaques, their inflammation must resolve, and ways to achieve this are the focus of this proposal.

PI_NAMEs: FISHER, EDWARD A (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;Adverse effects;Antigen Presentation;Arteries;Atherosclerosis;Cause of Death;cell type;Cells;chemokine receptor;Childhood;Cholesterol;Clinical;Coronary Arteriosclerosis;coronary plaque;Country;cytokine;Data;Development;Disease;disorder risk;effector T cell;Emigrations;Environment;Epigenetic Process;Event;Exposure to;Failure;Goals;Growth;Homeostasis;hypercholesterolemia;IL4 gene;Immune;Immune response;Immunity;Immunologic Memory;Impairment;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;inflammatory milieu;Knowledge;lipid mediator;Lipids;lymph nodes;Macrophage;Mediating;Molecular;mouse model;Movement;Myocardial Infarction;novel;novel therapeutics;Pathway interactions;Patients;peripheral tolerance;Play;Population;Populations at Risk;Predisposition;prevent;Property;Refractory;Regulation;Regulatory T-Lymphocyte;Resolution;response;restoration;Risk;Risk Factors;Role;single-cell RNA sequencing;Sterols;Systems Biology;T-Lymphocyte;tissue repair;Tissues;Training;transcriptomic profiling;WNT Signaling Pathway

PROJECT_TITLE: Molecular Regulation of Atherosclerosis Regression - Renewal

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Breast MRI has a high false positive rate which is a clinical concern that has questioned its use in many breast indications. As a result, significant opportunities exist to augment the diagnostic information derived from breast MR, especially if new data were generated that is coregistered with the MR image volume and seamlessly acquired during the same procedure with adjunctive technology that is relatively low in cost. The proposed project will develop an innovative multi-modality breast imaging platform that performs simultaneous Microwave and Magnetic Resonance Imaging (sMMRI) to address this need. If the studies proposed are successful, a new multi-modality breast imaging system will be realized by the end of requested funding period that is ready for use in larger statistically-powered clinical studies of its diagnostic performance in the future.

PI_NAMEs: MEANEY, PAUL M;PAULSEN, KEITH D. (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Benign;Binding;Biomedical Engineering;Breast;Breast Cancer Detection;breast exam;breast imaging;breast lesion;Breast Magnetic Resonance Imaging;Clinical;clinical imaging;Clinical Research;Clinical Trials Design;contrast enhanced;cost;Custom;Data;density;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Specificity;Diffusion Magnetic Resonance Imaging;electrical property;Electronics;experience;experimental study;Funding;Future;Gadolinium;Goals;Healthcare Systems;Image;image reconstruction;imaging platform;imaging potential;imaging properties;imaging system;Imaging Techniques;improved;improved outcome;industry partner;Injections;innovation;interest;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Measurement;microwave electromagnetic radiation;microwave imaging;multimodality;Noise;Outcome;Participant;Patients;Performance;Physics;Principal Investigator;Procedures;Process;Property;prototype;Radiology Specialty;reconstruction;Recovery;Research;research clinical testing;Resolution;Rotation;Safety;secondary endpoint;Serial Magnetic Resonance Imaging;Signal Transduction;Specificity;standard of care;Structure;System;Technology;Testing;Time;Tissue imaging;tissue mapping;Tissues;Translations;tumor microenvironment;Uncertainty;Water;Woman;Women's study

PROJECT_TITLE: Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care

PI_NAMEs: CHWASTIAK, LYDIA ANN (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Advanced Development;AIDS education;AIDS prevention;Anxiety;Applications Grants;Award;Behavioral Sciences;care providers;Caring;Clinical;clinically relevant;Collaborations;common treatment;community engagement;community partners;community partnership;community-centered;Complex;Consultations;cost effective;Country;Development;Educational workshop;Epidemic;evidence base;Faculty;follow-up;Funding;global health;Grant;Health;HIV;Hygiene;implementation research;improved;Incentives;Infrastructure;innovation;Institute of Medicine (U.S.);integrated care;Interdisciplinary Study;International;Intervention;Joints;Journals;learning network;London;Manuscripts;Maps;Medical;Medicine;meetings;Mental Depression;Mental disorders;Mental Health;mental health center;Mental Health Services;Meta-Analysis;Modeling;multidisciplinary;multiple chronic conditions;Needs Assessment;Outcome;Patients;peer;peer learning;Persons;Policies;Post-Traumatic Stress Disorders;prevention service;Process;programs;Provider;Psychiatry;psychologic;psychosocial;Publications;Ramp;Reporting;Research;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Risk;Risk Factors;Schools;Series;Services;Site;social;Societies;Structure;symposium;System;systematic review;testing services;Training and Education;treatment services;Underrepresented Populations;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Washington;webinar;World Health Organization;Writing

PROJECT_TITLE: Integrated Care Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cerebrovascular;Eye Disease and Disorders of Vision;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative This project will investigate novel diagnostic methods and potential treatment in animal models of twp macular degenerations: the RPE mitochondrial dysfunction model, and the Doyne Honeycomb Retinal Dystrophy model. As a result of this proposal, novel optical methods will be available for translation to diagnose retinal degenerations in human patients, including inherited and age-related macular degeneration (AMD). This study will also continue to lay a foundation for novel locally, light-activated drug delivery in human ocular disease.

PI_NAMEs: ZAWADZKI, ROBERT J (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;3-Dimensional;Acceleration;Affect;Age;age related;age related changes;Age related macular degeneration;Aging;Angiography;Animal Model;Animals;Basal lamina;Biochemical;Biological Assay;Biological Markers;Blood Circulation;Blood Vessels;Blood-Retinal Barrier;Bruch's basal membrane structure;capillary bed;cell type;Cells;Cellular Structures;Cholesterol;Choroid;cohort;Complement;Complex;confocal imaging;Custom;Data;Defect;Degenerative Disorder;density;Deposition;Deterioration;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Disease;Disease Progression;Doctor of Philosophy;Doyne honeycomb retinal dystrophy;Drug Delivery Systems;Drug Targeting;Electron Microscope;Electroretinography;Epithelial Cells;Evaluation;Exhibits;experimental study;extracellular;Extracellular Matrix;Eye;Eye diseases;feeding;Fluorescence;Foundations;Functional disorder;Genetic;Glucose;Goals;Grant;Health;High Fat Diet;Histologic;Hour;Human;Image;imaging platform;imaging system;Impairment;in vivo;in vivo optical imaging;Incubated;Individual;Inherited;innovation;Investigation;Label;Light;Light Microscope;Link;Lipids;Macular degeneration;Maps;Measurement;Measures;Methods;Microscope;Microscopy;mitochondrial dysfunction;Modeling;Molecular;Morphology;mosaic;multimodality;Mus;Mutation;nanoparticle;nanotherapy;Natural regeneration;neurovascular unit;novel;novel diagnostics;Nutrient;ocular imaging;Opsin;Optical Coherence Tomography;Optical Methods;optical spectra;Optics;Organelles;Oxidation-Reduction;Oxygen;particle;Pathology;Patients;Pharmaceutical Preparations;Photoreceptors;Point Mutation;Population;Predictive Value;Prevalence;Recycling;Resolution;Retina;Retinal Degeneration;retinal imaging;Retinal Photoreceptors;Retinoids;Role;S1-5 protein;Sclera;Speed;Stress;Structure;Structure of retinal pigment epithelium;System;Tail;targeted treatment;Testing;theranostics;Therapeutic;Therapeutic Agents;Thick;Time;Tissues;tool;Translations;Validation;Veins;Visual impairment;Vitamin A;Water

PROJECT_TITLE: Theranostics of Photoreceptor-RPE-Choroid Neurovascular Unit in Eye Diseases:


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: CLARK ATLANTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Pancreatic ductal adenocarcinoma (PDAC) has a notoriously high death rate due to a lack of early detection and early intervention. We identified CCL9 as new downstream of KrasG12D-mediated acinar-to-ductal metaplasia (ADM), the initial step of PDAC development. We will dissect the mechanisms of KrasG12D/CCL9 axis in regulating pancreatic ADM using 3D organoid cultures, and verify them in mouse models. Outcomes from this study will provide the essential groundwork for future studies on the potential use of CCL15, the human orthologue of CCL9, as one of the biomarkers for early detection in the clinic.

PI_NAMEs: LIOU, GEOU-YARH  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;Acceleration;Acinar Cell;Acinus organ component;Animal Model;antagonist;Back;biomarker identification;cancer cell;cancer diagnosis;Cancer Etiology;CCL15 gene;Cells;Cessation of life;chemotherapy;Clinic;Death Rate;Development;Diagnosis;Digit structure;Disease;Drug Targeting;Duct (organ) structure;early detection biomarkers;Early Diagnosis;Early Intervention;Event;fighting;Future;Gene Amplification;Goals;Growth;Human;immunoregulation;in vivo;Incidence;inhibitor;insight;Knock-out;KRAS oncogenesis;KRASG12D;Lesion;life span;Location;Macrophage;Maintenance;Malignant neoplasm of pancreas;Matrix Metalloproteinases;Mediating;Metaplasia;mouse model;mutant;Mutation;neutralizing antibody;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organoids;Outcome Study;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Pathologic;Patients;Physiological;premalignant;Process;RANTES;Reactive Oxygen Species;receptor;Regulation;Reporting;Signal Transduction;Survival Rate;Symptoms;System;TNF gene;Transgenic Mice;tumor;tumor initiation;Unresectable

PROJECT_TITLE: Dissecting mechanisms of tumor initiation via immunomodulation


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Regenerative medicine in the retina is an attractive solution for improving quality of life in patients affected by neurodegenerative diseases and depends on our knowledge of retinal development. Polycomb-group (PcG) complexes are evolutionarily conserved, powerful epigenetic machineries that regulate cell-fate decisions, and here, we identified retinal multipotency genes as novel targets of the PcG protein BCOR. Decoding how BCOR epigenetically regulates retinal neurogenesis may have wide implications for new targets in regenerative strategies.

PI_NAMEs: ZHANG, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Anophthalmos;Binding;Cell Differentiation process;Cell Extracts;Cell Line;Cell Reprogramming;cell type;Cells;Childhood;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Co-Immunoprecipitations;Complex;Congenital Disorders;Data;Defect;Dental Pulp;design;Development;Disease;Embryo;Epigenetic Process;epigenetic regulation;experimental study;Eye Development;Eye diseases;Frameshift Mutation;Gatekeeping;Gene Mutation;gene network;Generations;Genes;Genetic Transcription;Global Change;HDAC1 gene;Histone H2A;histone modification;Human;Immunofluorescence Immunologic;improved;In Situ Hybridization;in vitro Model;in vivo;induced pluripotent stem cell;knock-down;Knowledge;Late Effects;LHX2 gene;Link;Lysine;malignant neoplasm of eye;manufacture;Mass Spectrum Analysis;Mediating;Microdissection;Microphthalmos;Modeling;Modification;Mutate;Mutation;Neurodegenerative Disorders;neurogenesis;novel;optic cup;Optic vesicle;Organoids;Patients;Persons;Phenotype;Play;Polycomb;PRC1 Protein;Process;Proteins;Quality of life;Rana;RB1 gene;recruit;regenerative approach;Regenerative Medicine;Regulation;Repression;Retina;Retinal Degeneration;Retinal Diseases;retinal progenitor cell;Retinoblastoma;RNA;Role;Stains;stem cell genes;stem cells;Syndrome;Testing;Time;Tissues;Transcript;transcription factor;transcriptome sequencing;Variant;Vision;Visual Fields;Xenopus;Zebrafish

PROJECT_TITLE: Epigenetic Regulation of Retinal Development by BCOR


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Organ Transplantation;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative  Organ transplantation is a life saving therapy for individuals with end stage organ failure, but all transplants eventually fail due to a process called chronic allograft rejection. In this research proposal, we plan to evaluate the function of Neuropilin-2, which may serve as a novel co-inhibitory receptor to regulate the alloimmune response and thus prevent transplant rejection. We will perform in-depth mechanistic studies addressing the molecular basis for its function in immunity and we will determine if its biology can be a basis for future therapeutic development.

PI_NAMEs: BRISCOE, DAVID M. (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Address;allograft rejection;Allografting;angiogenesis;Antigens;Area;axon guidance;Binding;Biological;Biological Process;Biology;Boston;CD4 Positive T Lymphocytes;Cell Differentiation process;cell growth;Cell Lineage;Cell Physiology;Cell surface;cell type;Cells;Cellular Metabolic Process;Chronic;clinically relevant;Collaborations;Development;effector T cell;end-stage organ failure;Eragrostis;Family;FOXP3 gene;FRAP1 gene;Future;Graft Rejection;Graft Survival;Growth;heart allograft;Homeostasis;Human;Immune;immune function;Immune response;Immunity;immunoregulation;Immunosuppression;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;innovation;insight;interest;isoimmunity;Knock-out;Knockout Mice;Life;Ligands;Link;Literature;Malignant Neoplasms;Mediating;Mediator;Membrane Glycoproteins;Metabolic Pathway;migration;Minor;Modeling;Molecular;Mus;Neuropilin-1;Neuropilin-2;Neuropilins;novel;Organ Transplantation;Outcome;Pathway interactions;Pediatric Hospitals;pharmacologic;PIK3CG gene;plexin;post-transplant;prevent;Prevention;Process;Proliferating;receptor;Regulation;Regulatory T-Lymphocyte;Reporting;Research;Research Proposals;Resolution;response;restraint;Role;selective expression;SEMA3F gene;Semaphorins;Shapes;Signal Induction;Signal Transduction;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic development;Transplantation;tumor initiation;tumor progression

PROJECT_TITLE: Neuropilin-2 in Alloimmunity

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: FLAHERTY, BRIAN PATRICK (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive intervention;Applications Grants;Automobile Driving;Award;Behavior;Behavioral;Behavioral Research;Behavioral Sciences;Biometry;Clinical Sciences;Collaborations;Communication;Communities;Complement;Complex;complex data;Computer software;Consult;Consultations;Data;Data Analyses;Data Collection;data management;Data Set;data visualization;design;Development;Educational workshop;Ensure;Epidemic;Ethics;Evaluation;experience;Faculty;Funding;Grant;HIV;improved;Incentives;innovation;instrumentation;integrated care;interest;Intervention;Knowledge;Leadership;Measurement;meetings;Mental Health;mental health center;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;next generation;novel;Outcome;Paper;Pattern;Positioning Attribute;power analysis;Preparation;Process;Publications;Publishing;Qualitative Research;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Support;Resources;response;Science;Site;skills;smartphone based device;Statistical Data Interpretation;Statistical Models;statistics;Students;Techniques;Time;Training;Translational Research;Underrepresented Populations;Universities;Visit;visiting scholar;Washington;wearable device;Work;Writing

PROJECT_TITLE: Methods Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  This project responds to the research need of more diverse cohorts, more participants, more variables, and more occasions of measurement to advance progress in the epidemiology of cognitive resilience and decline. We will develop advanced models for causal mediation analysis based on Bayesian machine learning approaches along with computationally efficient and user-friendly R packages to integrate rich longitudinal data on exposures and health markers and account for biases inherent in observational data from life-course studies. The proposed approaches will enable causal inference on joint exposure effects and time-to-event and longitudinal mediators to inform policy for environmental exposures and cardiovascular health in mid and late life to prevent Alzheimer’s Disease and Related Disorders in diverse populations.

PI_NAMEs: VALERI, LINDA  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Accounting;Address;Air Pollutants;Air Pollution;Algorithms;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Arsenic;Bayesian learning;Blood Pressure;Boston;Cadmium;Carbon Black;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cessation of life;Chronic;Cognitive;cognitive function;cohort;Cohort Studies;Complex;Data;data fusion;Dementia;Diagnosis;Disease;disorder prevention;Dropout;Ensure;Environmental Exposure;Environmental Policy;Epidemiology;epidemiology study;Etiology;Event;Face;Functional disorder;Goals;Health;Health Care Costs;Heart;Heavy Metals;Hypertension;hypertension prevention;Impaired cognition;Incidence;Individual;Intervention;Investigation;Joints;late life;Life;Life course epidemiology;Life Cycle Stages;life span;Link;Longitudinal Studies;machine learning method;Measurement;Mediating;Mediation;Mediator;Metals;Methodology;Methods;middle age;model building;Modeling;modifiable risk;multi-component intervention;Native Americans;neurotoxic;normal aging;novel;novel strategies;Observational Study;Outcome;Participant;pollutant;Population Heterogeneity;prevent;Prevention;Process;Public Health;Reproducibility;Research;Research Personnel;resilience;response;Risk Factors;Role;Sampling Studies;Science;Selection Bias;Severities;simulation;statistical learning;Statistical Methods;Target Populations;Testing;Time;tool;translational study;usability;user friendly software;user-friendly;Work

PROJECT_TITLE: Bayesian Statistical Learning for Robust and Generalizable Causal Inferences in Alzheimer Disease and Related Disorders Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)M]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE: Vertebrate vision starts with a photochemical isomerization reaction involving proteins known as visual pigments that contain retinaldehyde as their chromophore. Despite the fundamental nature of the process and its relevance to human physiology and disease, many of its properties remain poorly understood. Here, we employ a host of new approaches enabled by the development of novel experimental tools to address critical questions pertaining to the functioning of the visual pigments as well as their abnormalities in retinopathies.

PI_NAMEs: KISER, PHILIP DAVID (contact);PALCZEWSKI, KRZYSZTOF

PROJECT_TERMS: absorption;Acceleration;Address;Affect;Agonist;Antibodies;Architecture;ARRB1 gene;Binding;Biochemical;Biological Assay;Biology;Chemicals;Chemistry;chromophore;cis trans isomerization;Complex;Cone;Crystallography;Dark Adaptation;Dependence;Detergents;Deuterium;Development;Disease;experience;experimental study;extracellular;Gases;Glean;Heart;Human;Hydrolysis;In Vitro;in vivo;insight;interest;Isomerism;Isotopes;Kinetics;Knockout Mice;Knowledge;Libraries;Light;Light Adaptations;Lipids;Mass Spectrum Analysis;Membrane;Membrane Proteins;metarhodopsin;Methodology;Methods;Micelles;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;mutant;nanobodies;Natural regeneration;Nature;novel;novel strategies;Ocular Physiology;Opsin;Penetration;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phospholipids;photoactivation;Photobleaching;Photochemistry;Photons;Phototransduction;Physiological;Physiology;Pigments;Play;Process;Property;Protein Conformation;Proteins;Reaction;receptor;regenerative;Research;response;Retina;Retinal Cone;Retinal Diseases;Retinal Pigments;Retinaldehyde;Rhodopsin;Rod Outer Segments;Role;Sampling;Schiff Bases;sensor;Series;Signal Transduction;small molecule;small molecule therapeutics;Stimulus;structural biology;Structure;Structure-Activity Relationship;Surface;Techniques;Testing;therapeutic candidate;Time;tool;Vertebrate Photoreceptors;Vision;Visual;visual cycle

PROJECT_TITLE: Chemical Biology of the Visual Pigments

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The research and training in this application will provide additional training and experience applying advanced intensive longitudinal statistical techniques to the study of aging and dementia. Outcomes in aging and Alzheimer disease (AD) research rely critically on the measurement of cognitive change and the innovative approaches described herein will provide novel and more sensitive analyses of longitudinal change. Ultimately, we will provide new cognitive endpoints for use in AD studies which will help establish the efficacy of candidate treatments.

PI_NAMEs: ASCHENBRENNER, ANDREW  (contact)

PROJECT_TERMS: Achievement;Adult;advanced analytics;Aging;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Attention;attentional control;Bayesian Modeling;behavior prediction;Biological;career development;Clinical;Clinical assessments;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive process;cognitive testing;cohort;Data Set;Dementia;design;Disease;disease phenotype;Disease Progression;drug efficacy;Encapsulated;Equation;Evaluation;experience;Goals;healthy aging;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;insight;International;Intervention;intervention effect;Intervention Studies;late life;longitudinal analysis;longitudinal design;magnetic resonance imaging biomarker;Measurement;Measures;Mentors;Minor;Modeling;Moods;Motivation;Nerve Degeneration;Noise;novel;older adult;Older Population;Outcome;Performance;Personality;Personality Assessment;Persons;Phenotype;Play;Positron-Emission Tomography;pre-clinical;predictive modeling;Prevention trial;Process;psychologic;Research;research clinical testing;Research Design;Research Technics;risk prediction;Secondary Prevention;Severities;Statistical Models;Stimulus;tau Proteins;Techniques;Testing;Time;Training;Validation;Variant;young adult

PROJECT_TITLE: Within-person dynamics of cognition and personality in healthy aging and Alzheimer's disease.

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: NARRATIVE The goal of this project is to develop a new instrument (w-DiFC) for optically detecting and counting rare circulating tumor cells continuously and non-invasively in awake, freely-moving mice. We will use this instrument to study CTCs during metastasis development and in response to radiation therapy in mouse models of cancer. We expect that w-DiFC will provide unique insights into metastasis biology and response to anti-cancer therapies.

PI_NAMEs: NIEDRE, MARK JONATHAN (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adjuvant;Affect;Algorithms;Animal Model;Animals;anti-cancer treatment;Anti-Inflammatory Agents;awake;Biology;Blood;Blood Circulation;Blood specimen;Blood Vessels;Blood Volume;Brain;Cancer Model;cancer therapy;Cell Count;Cell Survival;Cerebrospinal Fluid;Cessation of life;Childhood Malignant Brain Tumor;Childhood Medulloblastomas;Clinical;Complex;Data;Data Collection;Data Set;design;Detection;detection sensitivity;Development;Diffuse;Disease;Distant;Dose;Fiber;Flow Cytometry;Fluorescence;Future;Goals;Hematogenous;Hour;improved;In Vitro;in vivo;Individual;Inflammatory Response;insight;instrument;Lasers;Light;Lighting;liquid biopsy;Longitudinal Studies;Malignant Neoplasms;Mathematics;Measures;Mediating;Medulloblastoma;member;Metastasis Induction;Metastatic Neoplasm to the Leptomeninges;Methods;Modeling;Monitor;mouse model;Multiple Myeloma;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;non-invasive monitor;optical fiber;Optics;Organ;peripheral blood;Pharmaceutical Preparations;Pilot Projects;pre-clinical;Primary Neoplasm;Process;Proteins;Radiation;radiation response;Radiation therapy;Research;response;Sampling;Scanning;signal processing;Signal Transduction;Site;Surface;System;Techniques;Technology;Testing;Tissues;tool;Transgenic Mice;Transgenic Organisms;Treatment Protocols;tumor;Vertebral column;wearable device;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative (Public Health Relevance Statement): Huntingtin’s disease (HD) is based on a mutation in a gene called huntingtin. Huntington’s disease is inherited as autosomal dominant, which means that an affected parent would have a 50:50 chance of passing the gene to a child. All who inherit the mutation will eventually develop the disease, with impaired cognition (dementia), depression and apathy, and abnormal movements. Patients will need to receive long-term skilled nursing for many years. We discovered an advanced, modified small interfering RNA that can lower the mutant huntingtin that causes HD, setting the stage for this CREATE proposal. Advantages of this therapeutic are long-term activity (about six months) to lower huntingtin after a single injection into cerebrospinal fluid and, critically, widespread distribution and neuronal uptake over the entire non-human primate brain. Our discoveries will set the stage for a new paradigm of therapeutics for an array of neurological diseases, including those with increased numbers of repeats of sequences in genes, such as HD, other CAG repeat expansions, and brain diseases with dementia and movement problems (C9ORF based amyotrophic lateral sclerosis and frontal-temporal dementia). Our program has public health relevance. Diseases marked by dementia and severe movement limitations are expensive to society, by requiring high level nursing care. Patients are removed from the active work force, thus lowering their earning capacity. These diseases reduce the gross national product. The stress on public health for HD is that the disease affects individuals in the prime of their lives – magnifying the economic burden while intensifying family hardship. Reversing HD or delaying its onset will have economic as well as health benefits.

PI_NAMEs: ARONIN, NEIL  (contact)

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: Affect;Age;Amyotrophic Lateral Sclerosis;Animal Disease Models;autosome;Biological Assay;Blood Chemical Analysis;Bolus Infusion;Brain;Brain Diseases;Brain region;CAG repeat;Care given by nurses;Catheters;Cerebral Dominance;Cerebral Ventricles;Cerebrospinal Fluid;Chemicals;Chemistry;Child;Complete Blood Count;Coupling;Crowding;cytokine;DARPP;Data;Dementia;Disease;Dose;Drug Stability;drug testing;Dyskinetic syndrome;Economic Burden;Economics;effective therapy;Evaluation;Exhibits;Family;Female;Filtration;flexibility;Formulation;Frontotemporal Dementia;Genes;Genetic;Glial Fibrillary Acidic Protein;Goals;Gross National Product;Head;Health Benefit;High Pressure Liquid Chromatography;Human;Huntington Disease;Huntington gene;Hydrophobicity;Impaired cognition;in vivo;Individual;Inherited;Injections;Lateral;lateral ventricle;lead candidate;Magnetic Resonance Imaging;male;manufacture;Measures;Mental Depression;Messenger RNA;Modification;motor impairment;Movement;Mus;mutant;Mutation;Neostriatum;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropathology;nonhuman primate;nursing skill;Onset of illness;Outcome;Outcome Measure;Parents;Patients;phosphoramidite;polyglutamine;pressure;Process;process optimization;Production;programs;Property;Proteins;Public Health;public health relevance;research clinical testing;response;RNA Interference;Route;Safety;Secure;Severity of illness;Small Interfering RNA;Societies;Spinal;Stress;Structure;Testing;Therapeutic;therapeutic RNA;Time;Toxic effect;Transgenic Organisms;uptake;Western Blotting;Work

PROJECT_TITLE: Advancing RNA Therapeutics for Huntington’s Disease

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Health Services;Mental Health;Mental Illness;Nutrition;Pediatric;Primary Health Care

PHR: NARRATIVE Eating disorders have one of the highest mortality rates of any mental illness and affect an estimated half million American children and adolescents. Yet, it is exceptionally difficult for parents to find effective treatment for this condition as only 66 providers are certified to provide Family-Based Treatment, considered the most effective outpatient treatment for adolescent restrictive eating disorders. This study will determine whether a novel intervention that uses FBT strategies, Family Based Treatment for Primary Care (FBT-PC), designed for delivery by a primary care provider in the primary care setting, is feasible and could potentially address some of the widespread issues with access to evidence-based treatment for restrictive eating disorders in children and adolescents.

PI_NAMEs: LEBOW, JOCELYN REBECCA (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: acceptability and feasibility;access disparities;Address;Adolescent;Affect;Age;Ambulatory Care;American;Anorexia;arm;behavior change;Belief;Body Weight;Caregiver support;Caregivers;Caring;Case Series;Certification;Cessation of life;Characteristics;Child;Chronic;Clinic;Communities;comparison intervention;Data;Death Rate;Democracy;design;Disease remission;Distance Learning;Early Intervention;Eating Disorders;Educational process of instructing;effective therapy;Effectiveness;eligible participant;empowerment;Evaluation;evidence base;Evidence based treatment;experience;Family;family burden;feasibility testing;Goals;Health Services Accessibility;Healthcare Systems;illness length;illness perceptions;improved;improved outcome;Intervention;intervention delivery;Interview;Life;Link;Manuals;Measures;Medical;meetings;Mental disorders;Methodology;Methods;Nature;novel;operation;Outcome;Parents;participant enrollment;Patient Care;patient responsibilities;Patient-Focused Outcomes;Patients;pediatric patients;Perception;Pilot Projects;pilot trial;Play;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;Preparation;Primary Care;primary care provider;primary care setting;Process;Protocols documentation;Provider;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;reduce symptoms;Reporting;restrictive eating;retention rate;Role;rural setting;Sampling;Self Efficacy;Severities;Suicide;Survey Methodology;Symptoms;Testing;tool;tool development;Training;treatment strategy;treatment trial;trend;United States;weight restoration

PROJECT_TITLE: Evaluating the feasibility of a primary care-based treatment for restrictive eating disorders in children and adolescents


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE The anterior cingulate cortex (ACC) is necessary for emotional processing and social cognition, but how it encodes stimuli relevant to both processes is unknown. This proposal will provide much needed insight into how distinct neural representations are embedded within ACC excitatory and inhibitory subcircuits, and how this impacts encoding of diverse stimuli and cognitive function in rodents. This work contributes to our understanding of how the cortex encodes information across diverse contexts and provides insight into the complexity of neural processes involved in anxiety and social behavior.

PI_NAMEs: CRUZ-MARTIN, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: 3D Print;Acute;Adaptive Behaviors;Address;Anterior;Anterior Nuclear Group;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;Area;Automobile Driving;Behavior;Behavior monitoring;Behavioral;Behavioral trial;Biological Assay;Brain;Calcium;Categories;Cells;Cerebral cortex;cingulate cortex;Classification;classification algorithm;cognitive function;Complex;Contralateral;Data;Decision Making;Dependovirus;Electrophysiology (science);emotion regulation;Emotional;emotional behavior;Enterobacteria phage P1 Cre recombinase;excitatory neuron;Exhibits;Goals;Heterogeneity;Image;Implant;implantation;in vivo;Individual;individual response;Injections;insight;Interneurons;Label;Light;Maps;Methods;Microscope;miniaturize;Modeling;Molecular;molecular marker;Monitor;Morphology;Mus;neural;neuronal cell body;Neurons;optogenetics;Parvalbumins;Pattern;Population;Positioning Attribute;presynaptic;Probability;Process;Property;Pyramidal Cells;Rabies;Reporter;Resolution;response;Rodent;Role;Slice;social;Social Behavior;social cognition;Somatostatin;Source;Specificity;Stimulus;Synapses;Testing;Thalamic Nuclei;Transgenic Mice;Vasoactive Intestinal Peptide;Viral;Work

PROJECT_TITLE: Functional heterogeneity of vasoactive intestinal peptide-expressing interneurons in the anterior cingulate cortex

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF GHANA

PHR: Project Narrative West Africa is highly burdened with several vector-borne diseases, especially malaria, yet have very little research capacity, therefore, this training program offers the chance for a multi-site training of PhD and junior scientists/faculty who will become future research leaders. The proposed program will lead to the building and strengthening of local investigator capacity. Successful malaria and other vector-borne diseases control needs capacity building in disease endemic countries to establish a cadre of local scientists who can address the ongoing and evolving challenges in vector-borne diseases and control.

PI_NAMEs: AFRANE, YAW ASARE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Africa;African;Anti-malarial drug resistance;Area;Artemisinins;Bioinformatics;Burkina Faso;California;Career Mobility;Communicable Diseases;community involvement;Developed Countries;disease model;doctoral student;Educational workshop;Epidemiology;Faculty;Fostering;Gambia;Genetic;Genomics;Ghana;Goals;Health;Insecticide Resistance;Institution;Intervention;Knowledge;Malaria;malaria transmission;Medical Entomology;Medical Research;Mentorship;Modeling;Molecular;New Mexico;next generation;Pharmaceutical Preparations;Population;Population Genetics;Productivity;Publications;Research;Research Training;Science;Scientist;skills;Techniques;tool;Training;Training Programs;Universities;Vector-transmitted infectious disease

PROJECT_TITLE: Regional Centre for Vector Borne Diseases in West Africa (RCVBD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative Clinically used anesthetics primarily act upon GABAA receptors in the central nervous system to achieve hypnosis, amnesia and analgesia but they also induce profound changes in peripheral physiology. It has been long assumed that these peripheral physiological effects were mediated by neural outflow from the central nervous system but many peripheral tissues have been found to express GABAA receptors that can be directly modulated by GABAergic anesthetics. An understanding of GABAergic anesthetics’ functional effects on peripheral organs will not only allow mitigation of detrimental physiological changes during anesthesia but will identify novel therapeutic targets for hypertension, bronchoconstriction and immune disorders.

PI_NAMEs: EMALA, CHARLES W (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Amnesia;Anesthesia procedures;Anesthetics;Benzodiazepines;Bronchoconstriction;CD4 Positive T Lymphocytes;Cells;Central Nervous System;Clinical;Diagnostic Procedure;Disease;Goals;Human;Hypertension;Hypnosis;Hypotension;Immune;Immune System Diseases;immunoregulation;in vivo Model;Knowledge;Laboratories;Life;Ligands;Mediating;Muscle function;neural;Neurons;neurotransmission;new therapeutic target;novel;Operative Surgical Procedures;Organ;Patients;Penetration;Peripheral;Peripheral Nervous System;Physiological;Physiology;programs;Propofol;receptor;Receptor Cell;respiratory smooth muscle;response;Rodent;Sedation procedure;sedative;Signal Transduction;Smooth Muscle;Source;therapeutic target;Tissues;Unconscious State;Vascular Smooth Muscle

PROJECT_TITLE: Anesthetics' Effects on Physiological Responses Modulated by Peripheral GABAA Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: BOSTON

PHR: Project Narrative: The proposed research aims to develop, translate, and validate innovative in-vivo imaging technologies to improve imaging and studying the development of the human fetal brain before birth. The technology will enable and improve studies on the development of the brain in fetuses with congenital disorders or fetuses at risk of having neurodevelopmental issues later in life. This in-turn is expected to result in timely and more effective treatments and therapeutic interventions that will lead to vastly improved patient outcomes in both the short- and long-term, effectively reducing the burden of human disabilities arising from congenital disorders.

PI_NAMEs: GHOLIPOUR-BABOLI, ALI  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Affect;Algorithms;Anatomy;Birth;Brain;brain tissue;Cell Physiology;Cell Proliferation;Classification;Clinical Trials;Cognitive;cognitive disability;Compensation;Complex;Congenital Disorders;congenital heart abnormality;convolutional neural network;cost effective;Data;Data Set;deep learning;deep learning model;density;Development;disability;effective therapy;fetal;Fetal Development;Fetus;fetus at risk;Gestational Age;Head;Health Care Costs;High Prevalence;Human;Human Development;Hypoxia;Image;image processing;image reconstruction;Imaging technology;improved;in vivo;in vivo imaging;Injury;innovation;Investigation;large datasets;Life;Live Birth;Magnetic Resonance Imaging;Manuals;Measures;Mental Health;migration;Modeling;Morphologic artifacts;Mothers;Motion;Multicenter Studies;myelination;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurology;Neurons;Neurosciences;new technology;next generation;Noise;novel;Outcome;Patient-Focused Outcomes;Patients;Play;Positioning Attribute;prenatal;Process;Property;prospective;real-time images;Real-Time Systems;reconstruction;recurrent neural network;Relaxation;Reproducibility;Research;Resolution;Role;Rotation;Sampling;Scanning;Second Pregnancy Trimester;Signal Transduction;Site;Slice;Speed;success;System;Systems Integration;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;Training;Translating;Uterus;virtual

PROJECT_TITLE: Next-generation in-vivo fetal neuroimaging


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The proposed research is relevant to public health because it will generate new tools to understand neurotrauma and discover personalized therapies for it. It will also contribute a three-dimensional multi- electrode array that will enable the first, long-term field recordings from brain organoid models. These contributions support the mission of the National Institute of Neurological Disorders and Stroke.

PI_NAMEs: FINAN, JOHN D (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Accelerometer;Address;Adherence;Adherent Culture;behavior test;Biological Sciences;Biomedical Engineering;Blood;Brain;candidate identification;Caring;Cause of Death;Cell Culture Techniques;Cells;clinically relevant;Collaborations;Complex;Data;design;Development;disability;Disease;drug discovery;electric field;Electrodes;Electroencephalography;Electrophysiology (science);Engineering;Ethical Issues;Ethics;Etiology;Experimental Genetics;experimental study;fascinate;flexibility;Genes;Genetic Identity;genetic variant;Genome;Genotype;Goals;Helmet;Human;In Vitro;in vitro Model;insight;Measures;Mechanics;millimeter;Mission;Modeling;Molecular;multi-electrode arrays;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Nervous System Trauma;neural;Neurons;novel;Organoids;Outcome;Output;Pathology;Patients;personalized medicine;phase III trial;Phenotype;physical science;Population;precision medicine;Proteomics;Public Health;Research;response;Rest;Risk;Risk Assessment;Risk Factors;Role;Secure;serial imaging;Skin;spheroids;stem cell technology;stem cells;Stretching;Structure;success;synergism;TBI Patients;TBI treatment;Testing;three dimensional cell culture;Time;tool;Trauma;Traumatic Brain Injury;United States;Work

PROJECT_TITLE: Novel tools for in vitro electrophysiology and neurotrauma modeling

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: POST-TRANSLATIONAL MODIFICATION OF CX43 REGULATES MYOMETRIAL QUIESCENCE Preterm labor leads to preterm delivery of an underdeveloped fetus in 50% of cases and there are no FDA-approved medications available to prevent preterm delivery. The research planned in this application will employ tissues and cells from pregnant women. We will examine the role of endogenous nitric oxide, which relaxes the muscle of the term, but not preterm human uterus, in regulating the formation of gap junctions that couple the tissue electrically and coordinate labor contractions.

PI_NAMEs: BUXTON, IAIN L (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acute;Affect;African American population;African American Women;Agonist;Birth;Blood flow;C-terminal;Caucasians;Cells;Cessation of life;Connexin 43;Coupling;Cyclic AMP;Cyclic GMP;Cysteine;Cytosol;Development;disability;Disparate;Dose Limiting;Ethnic Origin;extreme prematurity;FDA approved;Fetus;Functional disorder;Future;gap junction channel;Gap Junctions;Generations;Giant Cells;health disparity;Hour;Human;innovation;interest;Label;Labor Onset;Link;Maintenance;Measures;Mechanics;Mediating;Medical;Membrane;Methods;Modification;monolayer;Mothers;Muscle Cells;Muscle relaxation phase;mutant;Mutate;Mutation;Myometrial;myometrium;Nitric Oxide;Nitrosation;novel;Outcome;Outcomes Research;overexpression;Oxidoreductase;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Pregnancy;pregnant;Pregnant Uterus;Pregnant Women;Premature Birth;Premature Infant;Premature Labor;prevent;Property;protein expression;Protein Kinase;protein kinase C epsilon;Regulation;Relaxation;Research;response;Risk;Role;S-Nitrosoglutathione;Serine;Site;Smooth Muscle;Smooth Muscle Myocytes;Stretching;Terbutaline;Testing;Therapeutic;Time;Tissues;Tocolysis;Tocolytic Agents;translational approach;uterine smooth muscle cell;Uterus;Vascular Endothelial Cell

PROJECT_TITLE: Post-translational Modification of Cx43 Regulates Myometrial Quiescence

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: While most older adults exhibit cognitive decline as they age, there are exceptions to this rule; certain elderly individuals actually show no age-related decrease in memory. Based on our previous research with a group of these remarkable older adults, we hypothesize that a motivation to engage with, rather than withdraw from, high arousal states associated with challenging tasks is an important protective factor in aging, including in people with Preclinical AD. In the proposed research we will examine neural, physiological, and motivational patterns associated with persistence in the face of challenge, in order to identify potential biomarkers of successful aging.

PI_NAMEs: BARRETT, LISA FELDMAN;DICKERSON, BRADFORD C (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Affect;Affective;Age;age related;age related decline;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;American;Amygdaloid structure;Amyloid;Anatomy;Arousal;Autonomic nervous system;behavior measurement;Behavior Therapy;biobehavior;Biological;Biological Markers;biopsychosocial;Body System;Brain;Cardiac Output;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive function;cognitive performance;cognitive task;Communication;Deterioration;Development;Dimensions;Elderly;Enabling Factors;Exercise;Exhibits;experience;Functional disorder;Funding;Goals;Health;healthy aging;Heterogeneity;Impaired cognition;Impairment;improved;Individual;Individual Differences;individual variation;innovation;insight;Intervention;Intervention Studies;lifestyle intervention;Measures;Memory;Modeling;Motivation;neural;neural patterning;Neurobiology;neuroimaging;neuromechanism;neuropathology;novel strategies;older adult;Outcome;Outcome Measure;Outcomes Research;Participant;Pattern;Performance;Persons;Physiological;Physiological Processes;Population;potential biomarker;pre-clinical;predictive marker;preservation;promote resilience;protective factors;psychologic;Public Health;Research;resilience;response;Role;Sampling;Structure;Subgroup;Testing;Vascular resistance;Visceral;young adult

PROJECT_TITLE: Biopsychosocial Mechanisms of Successful Aging


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Mental Health;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Social virtual reality has the potential to improve not only the treatment of pain and other burdensome symptoms in older hospitalized patients, but also the overall experience of hospitalization. The planned study aims to establish the feasibility, acceptability and usability of SVR; these data will support a future R01 application. Given documented high rates of trauma-related pain we target older adult trauma patients. However, in the long term we expect this type of intervention will have broad utility for other populations.

PI_NAMEs: WON, ANDREA STEVENSON (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;acute care;addiction;Address;Admission activity;Adverse event;Age;aging population;Anxiety;anxiety reduction;authority;Constipation;cost;Data;Data Collection;Delirium;depressive symptoms;Development;Ecological momentary assessment;Equilibrium;experience;falls;Family;Family member;Feedback;Follow-Up Studies;Friends;Future;health care settings;Hospitalization;Hospitals;human old age (65+);improved;Infection Control;infection risk;Intervention;Interview;iterative design;Length of Stay;Link;Measures;Methods;Moods;Morbidity - disease rate;novel;older adult;older patient;Operative Surgical Procedures;opioid use;Outcome Measure;Outpatients;Pain;Pain management;pain reduction;Pain Threshold;Participant;Patient Care;patient population;Patients;Perception;Persons;Pharmaceutical Preparations;Physical environment;Pilot Projects;Play;Population;post intervention;post-trauma;prescription opioid;prevent;Protocols documentation;recruit;Rehabilitation therapy;Research;Research Assistant;Risk;Risk Factors;satisfaction;social;social engagement;Social Interaction;Social isolation;Social support;standard measure;Surveys;Symptoms;Technology;Telephone;Testing;Text Messaging;therapy design;Trauma;Trauma patient;Travel;usability;Videoconferencing;virtual environment;virtual reality;virtual reality environment;virtual reality intervention;Visual impairment;Work

PROJECT_TITLE: Social Virtual Reality Experiences for Hospitalized Older Adult Trauma Patients to Reduce Pain

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]