NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE The transition from pediatric to adult care is marked by significant instability and risk of morbidity, mortality, and reduced lifespans for youth impacted by chronic kidney disease. Thisis the result of poor engagement in collaborative decision making by CKD youth with their caregivers and clinicians. Facilitating collaborative decision making with all stakeholders may improve outcomes for CKD youth as they transition to adult care.

PI_NAMEs: POLLACK, ARI  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adherence;Adult;Allografting;Biological;Caregivers;Caring;Child;Childhood;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Trials;Decision Aid;Decision Making;design;Development;Dialysis procedure;Diet;Disease;Disease Progression;Educational process of instructing;Effectiveness;empowerment;Ensure;Family;Fostering;Future;Goals;Grant;Health;health literacy;health related quality of life;Health Status;Image;improved;improved outcome;Individual;interoperability;Interview;Lead;Learning;life span;Life Style;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;novel;Outcome;Parents;Patients;pediatric patients;Pediatrics;Pharmaceutical Preparations;Phase;preference;Prevalence;Process;programs;prototype;Quality of life;Research;Risk;Role;satisfaction;Self Efficacy;Self Management;skills;Surveys;System;Technology;Time;tool;Transplantation;usability;Work;Youth

PROJECT_TITLE: Kids CoLab - Supporting collaborative decision making with youth impacted by chronic kidney disease

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Congenital Structural Anomalies;Mental Health;Neurosciences;Nutrition;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative The proposed research aims to translate findings from basic science to create outcome measures and lay the groundwork for a potential clinical trial in Kabuki syndrome providing a novel treatment option to a clinical entity (intellectual disability) that has few therapeutic options. In addition to creating outcome measures and providing information for Kabuki syndrome that may be applicable to other rare diseases as well, understanding more about the cellular mechanisms resulting in impaired cognition in KS may provide a window into the mechanisms underlying normal cognition and memory and learning, and pathologic states – specifically intellectual disability.

PI_NAMEs: HARRIS, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adult;adult neurogenesis;Age;Anxiety;Area;Atkins Diet;Basic Science;Behavior;Behavioral;behavioral outcome;Blood;brain volume;Cells;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive performance;cognitive testing;Data;Defect;dentate gyrus;Diet;Disease;efficacy testing;Foundations;Genetic;Genetic Diseases;granule cell;gray matter;Handedness;Hippocampus;Histone Deacetylase Inhibitor;Impaired cognition;Impairment;improved;Individual;insight;Intellectual functioning disability;Kabuki Make-Up Syndrome;ketogenic diet;Ketones;Ketosis;Learning;Life;Link;loss of function;Magnetic Resonance Imaging;Measures;Memory;Monitor;mouse model;Mus;Mutation;Neuroanatomy;neurobehavioral;neurobehavioral test;Neurocognitive;neurogenesis;neuroimaging;novel;Other Genetics;Outcome;Outcome Measure;Participant;Pathogenesis;Pathologic;Pathological anxiety;Patients;Performance;Phenotype;Pilot Projects;Population;postnatal;Property;prospective;Prospective Studies;Protocols documentation;Proxy;Questionnaires;Radiology Specialty;Rare Diseases;rare genetic disorder;recruit;Research;sex;study population;Techniques;Testing;Therapeutic;Translating;treatment trial;Urine;Variant;Visuospatial;Work

PROJECT_TITLE: Preparing for a Clinical Trial in Kabuki Syndrome- Characterization of Cognitive and Neuroanatomical Features and Pilot Treatment Trial

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: ORLANDO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed study is highly significant because it targets a disproportionately affected group, Latinx men who have sex with men, and tests a culturally adapted, flexible intervention, Connecting Latinos en Parejas, developed specifically for Latinx male couples. The project is innovative in that it includes Latinx couples regardless of HIV status and expands prevention alternatives offered in other couples-based interventions by incorporating biomedical prevention methods such as pre-exposure prophylaxis (PrEP), promoting engagement in care, adherence to treatment regimens and viral suppression (TasP) and encouraging routine HIV testing if appropriate given the couple’s serostatus. Our intervention targets multiple points in the HIV Prevention and Care Continuum and is responsive to the Ending the HIV Epidemic Initiative and National HIV/AIDS Strategy (2022-2025).

PI_NAMEs: JOHNSON, MALLORY O;MARTINEZ, OMAR  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Affect;AIDS prevention;Alcohol abuse;Algorithms;Anal Sex;Area;Attention;Automobile Driving;Behavioral;Biological;Biological Markers;Bisexual;Black race;Caring;community intervention;community organizations;condomless anal sex;condoms;contextual factors;Continuity of Patient Care;coping;Couples;cultural competence;Data;design;Discrimination;Education;efficacious intervention;efficacy evaluation;efficacy testing;Emergency Situation;Environmental Risk Factor;Epidemic;experience;flexibility;follow-up;Gays;Geography;Hair;Health;Hispanic;HIV;HIV Infections;HIV prevention trial;HIV risk;HIV/AIDS;Homosexuality;Human immunodeficiency virus test;Immigration;improved;Individual;infection rate;innovation;Intervention;Knowledge;Latino;Latino Population;Latinx;Linguistics;male couples;marginalization;Measures;Mediator;men;men who have sex with men;Methods;Not Hispanic or Latino;novel;Outcome;Participant;perceived discrimination;Perception;personalized approach;Population;pre-exposure prophylaxis;Prevention;Prevention strategy;preventive intervention;primary outcome;Procedures;Protocols documentation;psychoeducation;psychosocial;Psychosocial Factor;Randomized;Randomized, Controlled Trials;Recommendation;recruit;remote delivery;Reporting;Research;Risk;Risk Reduction;scale up;self testing;sexual minority;skills;social;social cognitive theory;social factors;social media;Social Network;social stigma;stressor;structural determinants;substance use;success;sustainability framework;Techniques;Testing;Time;transmission process;treatment as prevention;Treatment Protocols;Viral;Work

PROJECT_TITLE: Connecting Latinos en Pareja: A Couples-based HIV Prevention Intervention for Latino Male Couples

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Foodborne Illness;Infectious Diseases;Microbiome;Nanotechnology;Patient Safety

ORG_CITY: DURHAM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Bacteria in biofilms, not individual or free swimming (ie planktonic), contaminate food, can spread bacteria when surfaces are cleaned, and are responsible for 80% of all hospital acquired infections, about 1.6 million infections and 80,000 deaths, at an annual cost of $16.8 to $27.2 billion dollars in the US. Biofilm development and reaction to antibiotics are dependent on the geometry being studied, nutrient, and liquid flow conditions and there are currently no relations able to translate between one set of conditions and another. This project seeks to create platforms and mathematical relations that will increase the ability of researchers, clinicians and manufacturers, translate from fundamental studies on biofilms with finite time scales and materials to infections and surfaces.

PI_NAMEs: JONES, AKHENATON-ANDREW DHAFIR (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: 3D Print;Affect;Animals;Antibiotics;Bacteria;Candida;Candida albicans;Cells;Cessation of life;Clinical;Communication;Consumption;cost;Development;Devices;Engineering;Food Contamination;Geometry;Hygiene;Infection;Liquid substance;Manufacturer;Mathematics;Medical Device;medical implant;Meropenem;Microbial Biofilms;Milk;Monitor;nanoparticle;Nosocomial Infections;Nutrient;Operative Surgical Procedures;Play;polymicrobial biofilm;programs;Pseudomonas aeruginosa;Reaction;Rejuvenation;Research;Research Personnel;Risk;Role;Rotation;Sanitation;secondary infection;shear stress;Stress;sugar;Surface;Swimming;System;Temperature;Time;Translating;uptake;wasting

PROJECT_TITLE: Developing platforms for studying the impact of external stresses on multispecies biofilms.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Opioid addiction is a major public health crisis in the United States, and treatment of opioid addiction is hindered by high rates of relapse after abstinence. We here study the changes to medial orbitofrontal cortex in mice and rats in response to oxycodone withdrawal and relapse by integrating connectivity, gene expression, and genome accessibility measurements at the level of single cells and identify conserved core changes by comparing across species and behaviors. Our work contributes to the basic understanding of the connectomic and epigenomic changes in opioid addiction and aims to identify conserved changes for treatment.

PI_NAMEs: KEBSCHULL, JUSTUS M (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Abstinence;American;Axon;Bar Codes;Behavior;Brain;Brain Mapping;cell type;Cells;Chronic;Epidemic;Epigenetic Process;epigenomics;experimental study;Gene Expression;Genome;High-Throughput Nucleotide Sequencing;Incidence;Knock-out;Label;Maps;Measurement;Measures;Medial;Messenger RNA;Methods;Modality;Modeling;multiple omics;Multiplexed Analysis of Projections by Sequencing;Mus;Neurons;Opiate Addiction;opioid exposure;opioid withdrawal;overexpression;Oxycodone;Pattern;Public Health;Rattus;Relapse;Resolution;response;RNA;Rodent;Rodent Model;Technology;tool;transcriptome;transcriptomics;United States;Withdrawal;Work

PROJECT_TITLE: IDENTIFYING EPIGENOMICS AND CONNECTOMICS OF PROTRACTED OPIOID WITHDRAWAL AND RELAPSE USING CELLULAR BARCODING


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Pain Research;Pediatric;Physical Activity;Prevention;Rehabilitation;Telehealth

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative There is a critical need to develop digitally delivered behavioral interventions for adolescents with chronic pain to drastically increase the reach of evidence-based interventions around the country and worldwide. This proposal seeks to systematically develop and evaluate the feasibility and preliminary effectiveness of a digital exposure treatment for adolescents with chronic musculoskeletal pain, utilizing a sequential replicated and randomized single-case experimental design (SCED) and incorporating innovative technology for remote biomechanical and daily physical activity assessment. Agile research methods will allow for a rapid, iterative development and evaluation of the intervention which will be further evaluated in a pilot trial utilizing SCED, providing the opportunity to rapidly and pragmatically evaluate treatment effectiveness in small cohort— ultimately yielding a clinically useful, evidence-based digital solution.

PI_NAMEs: HARRISON, LAUREN ELISABETH (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acceptability and feasibility;actigraphy;Active Learning;Adherence;adherence rate;Adolescence;Adolescent;Adult;Affect;Age;Arthritis;barrier to care;Behavior Therapy;behavioral health intervention;biomechanical test;Biomechanics;career;career development;Cellular Phone;Childhood;chronic musculoskeletal pain;chronic pain;Clinical;clinical care;Clinical Research;Clinical Trials;cohort;Computers;cost;Country;COVID-19 pandemic;Data;Data Collection;design;Development;Development Plans;Devices;diaries;digital;digital delivery;digital health;digital intervention;digital solutions;disability;dissemination science;Distress;Education;Effectiveness;Evaluation;evidence base;Evidence based intervention;Evidence based program;experience;Experimental Designs;Feedback;flexibility;follow-up;Fright;functional disability;Funding;Goals;Grant;Health Services Accessibility;high risk;Impairment;implementation science;improved;Individual;innovation;innovative technologies;insight;Intervention;Interview;joint biomechanics;Life Cycle Stages;Living Wills;Maintenance;Measures;Medicine;Mentors;Mentorship;Methods;mHealth;Modeling;Monitor;multidisciplinary;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;opioid misuse;Outpatients;Pain;pain reduction;Parents;Participant;patient oriented;Patients;Phase;Physical activity;pilot trial;Prevention;Process;prototype;Provider;Randomized;Randomized, Controlled Trials;remote assessment;remote technology;Research;Research Methodology;Research Support;response;retention rate;Risk;satisfaction;Scientist;Secure;Services;social;societal costs;statistics;Structure;Tablets;Teenagers;theories;Time;Training;Treatment Effectiveness;user centered design;Vocation;Waiting Lists;Writing;Youth

PROJECT_TITLE: Agile Development of a Digital Exposure Treatment for Youth with Chronic Musculoskeletal Pain

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Relevance statement A multitude of human diseases result from defects in genome maintenance and are characterized by profound neurodevelopmental abnormalities and neurodegeneration, even brain tumors, illustrating the importance of DNA repair for brain health. Therefore, understanding how DNA repair pathways function in the brain is critical for the development of treatments for these and other diseases. This grant application proposes a research plan to answer gaps in our knowledge concerning a specific cell type in the brain called glia, and how genome damage in these cells contribute to disease processes.

PI_NAMEs: MCKINNON, PETER J (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;age related;Applications Grants;Architecture;Astrocytes;ATAC-seq;Base Excision Repairs;Biology;Brain;brain health;Brain Neoplasms;Cell Physiology;cell type;Cells;Chromatin;cognitive ability;Critical Pathways;Cytoplasmic Granules;Data;Defect;Disease;disease model;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;DNA strand break;Engineering;Event;Excision Repair;experimental study;Functional disorder;Gene Deletion;Gene Expression;Gene Mutation;Genetic Transcription;Genome;genome integrity;Genome Stability;Genomic Instability;genomic locus;Genotoxic Stress;genotoxicity;Germ-Line Mutation;Goals;Health;Homeostasis;homologous recombination;Human;human disease;Human Genome;in vivo;Inherited;Knowledge;Link;Maintenance;Microglia;Modeling;Molecular Conformation;mouse model;myelination;Nerve Degeneration;nerve stem cell;Nervous System;Nervous System Disorder;nestin protein;neural;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;neuroinflammation;Neurologic;neuron loss;Neurons;neuropathology;Nonhomologous DNA End Joining;novel;oligodendrocyte lineage;Oligodendroglia;oxidative damage;Pathogenesis;Pathway interactions;Phosphoric Monoester Hydrolases;Polynucleotide 5'-Hydroxyl-Kinase;Population;Predisposition;Process;pseudotoxoplasmosis syndrome;Quality of life;repaired;Research;response;Ribonucleotides;Role;Signal Transduction;spatiotemporal;Spinocerebellar Ataxias;Susceptibility Gene;Syndrome;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy development;transcriptome sequencing;treatment strategy;virulence gene;white matter

PROJECT_TITLE: Genome Stability in Glia & Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Overall – Project Narrative The Wake Forest Alzheimer’s Disease Research Center (ADRC) was founded only 4 years ago but has made remarkable progress toward its mission to promote research focused on strategies for preventing and treating Alzheimer’s disease (AD) and related disorders. We have a special focus on understanding how common medical conditions such as prediabetes, diabetes and hypertension influence the risk of AD, and how risk is influenced by health disparities of underrepresented groups. We will make important contributions that include critical research resources and highly trained investigators to the national ADRC network to address these questions and work together toward our common goal of developing effective methods to prevent, treat, and cure AD.

PI_NAMEs: CRAFT, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Address;Adult;African American;African American population;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Area;behavioral neurology;Biological Markers;Blood Vessels;Capsicum;Clinical;clinical center;clinical implementation;Clinical Sciences;Clinical Trials;Cognition;cohort;Collaborations;Communities;Complex;Data;data management;Dementia;Diabetes Mellitus;Dimensions;Disease;disease heterogeneity;Doctor of Philosophy;Early Intervention;Ecosystem;Education;education research;Enrollment;Ensure;Epidemic;experience;Faculty;Faculty Recruitment;Family;Foundations;Functional disorder;Funding;General Population;Goals;Grant;health disparity;health equity;Health Professional;Heterogeneity;High Prevalence;Human;Hypertension;imaging biomarker;Impaired cognition;Infrastructure;innovation;Institution;Intervention Trial;investigator training;late life;Leadership;Magnetic Resonance Imaging;Medical;medical schools;Metabolic;Metabolic Diseases;Methods;Mission;Modeling;neuroimaging;neuropathology;Neurosciences;nonhuman primate;normal aging;novel;novel strategies;older adult;outreach;Participant;Patient Education;Patients;Phase Transition;Play;Positron-Emission Tomography;Prediabetes syndrome;Predictive Factor;Prevalence;prevent;Prevention;Prevention strategy;preventive intervention;programs;Publications;recruit;Reduce health disparities;repository;Research;Research Activity;Research Infrastructure;Research Personnel;resilience;Resources;Risk;Risk Factors;Role;Sampling;Statistical Data Interpretation;Strategic Planning;symptom treatment;Symptoms;tau Proteins;Testing;Training;translational pipeline;Translational Research;Underrepresented Populations;Vascular Diseases;vascular factor;vascular risk factor;Work

PROJECT_TITLE: Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PROJECT_TERMS: Achievement;Action Research;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Area;Award;Blood Vessels;career;Clinical;Clinical Sciences;Collaborations;Communities;Consultations;Creativeness;Data;data management;Dementia;Development;disease heterogeneity;Education;Ensure;Ethics;Feedback;Fostering;Goals;Growth;health disparity;human subject;imaging biomarker;Infrastructure;innovation;Institution;Interdisciplinary Education;Interdisciplinary Study;Lead;Leadership;member;Metabolic;Mission;model design;Nature;neuropathology;normal aging;novel;Participant;Performance;Phenotype;Policies;Process;Program Evaluation;programs;Regulation;repository;Research;Research Personnel;Resources;Risk;Role;Series;Services;Specimen;success;translational model;Translational Research;translational scientist;trial design;Universities;vascular factor;Vision;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Nonalcoholic steatohepatitis (NASH) is a common liver disease, and macrophages, which are cells of the im- mune system, play a pivotal role in disease progression. The proposed project will contribute to our under- standing of macrophage function and NASH progression to highlight the clinical utility of targeting these cells in NASH. Ultimately, our studies may lead to new therapeutic options that will improve patient health and quality of life.

PI_NAMEs: FERGUSON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;anaerobic glycolysis;Anti-Inflammatory Agents;Attenuated;Automobile Driving;Bioenergetics;Bone Marrow;Cells;Cirrhosis;Citric Acid Cycle;Clinical;Clinical Trials;Coculture Techniques;comorbidity;Complex;Data;Development;dietary;Disease;Disease Progression;end stage liver disease;Event;Fibrosis;Gene Expression;Gene Expression Profile;Genes;Genetic;Glycolysis;Goals;Health;healthcare burden;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;hypoxia inducible factor 1;Immune;Immune system;improved;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;Innate Immune System;innovation;intercellular communication;Licensing;Lipopolysaccharides;Liver;Liver diseases;Liver Failure;liver injury;liver repair;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Mitochondrial Matrix;mitochondrial metabolism;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;nonalcoholic steatohepatitis;novel;novel therapeutics;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Play;Population;Primary carcinoma of the liver cells;Process;Production;protein expression;Proteins;Pyruvate;pyruvate carrier;Quality of life;repair function;response;Risk;Role;single-cell RNA sequencing;stellate cell;Stimulus;Testing;therapeutic target;transcription factor;Transgenic Mice;Tricarboxylic Acids;Work

PROJECT_TITLE: Macrophage Mitochondrial Pyruvate Carrier in Nonalcoholic Steatohepatitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Skeletal muscle insulin resistance accounts for ~90% of the reduction in insulin-stimulated glucose clearance in type 2 diabetic individuals. Alteration in lipid metabolism has been implicated for the pathogenesis of muscle insulin resistance, but the exact identify of the lipid-mediated mechanism that suppresses muscle insulin action in humans remains inconclusive. In this proposal, the role of lyso-phospholipids on skeletal muscle insulin sensitivity will be investigated.

PI_NAMEs: FUNAI, KATSUHIKO  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acceleration;Acyltransferase;Affect;Arachidonic Acids;Biochemical;Cell membrane;Data;Deceleration;Defect;desensitization;Development;Diabetes Mellitus;diabetic;Diet;diet-induced obesity;Exercise;exercise training;Gene Expression;Genetic;Glucose;Glucose Clamp;glucose uptake;Heterodimerization;Human;Hyperglycemia;Hyperinsulinism;Individual;Insulin;Insulin Receptor;Insulin Resistance;insulin secretion;insulin sensitivity;insulin signaling;Islets of Langerhans;Laboratories;lipid metabolism;Lipids;Lysophosphatidylcholines;Lysophospholipids;Measures;Mediating;Membrane Microdomains;Metabolism;Molecular;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Obesity;overexpression;Pathogenesis;pharmacologic;Phosphorylation;prevent;Publishing;Rattus;Receptor Signaling;Role;Signal Transduction;Skeletal Muscle;stable isotope;Testing;Tissues;Type 2 diabetic;Tyrosine Phosphorylation;Visual

PROJECT_TITLE: Lands cycle and skeletal muscle insulin action

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE A large number of diseases are now recognized as `conformational diseases', caused by protein misfolding and subsequent aggregation. One example is hepatic fibrinogen storage disease (HFSD), where the underlying cause is the endoplasmic reticulum (ER) retention and aggregation of fibrinogen mutants, leading to liver damage, hypofibrinogenemia, and excessive bleeding. Serendipitously, we have uncovered an important role of ER-associated degradation (ERAD) in the biogenesis and quality control of both wildtype fibrinogen and disease-causing mutants of fibrinogen.

PI_NAMEs: SUN, SHENGYI  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adult;Age;Age Months;Autophagocytosis;autosome;Biochemical;Biogenesis;Biological Assay;Blood coagulation;cell type;clinically relevant;Coagulation Process;Data;Disease;disulfide bond;Dominant-Negative Mutation;Endoplasmic Reticulum;Event;Exhibits;FGF21 gene;Fibrinogen;fibroblast growth factor 21;Growth;Hemorrhage;Hepatic;Hepatocyte;Homeostasis;Human;human disease;Imaging Techniques;Inclusion Bodies;insight;Label;Liver;liver injury;misfolded protein;Missense Mutation;Molecular;Molecular Chaperones;Molecular Conformation;Mus;mutant;novel;Pathogenesis;Pathogenicity;Pathologic;Patients;prevent;protein complex;protein misfolding;Proteins;proteostasis;Quality Control;recruit;response;Role;Testing;Therapeutic;Transmission Electron Microscopy;ubiquitin-protein ligase

PROJECT_TITLE: Novel Mechanism underlying fibrinogen biogenesis in the endoplasmic reticulum

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Kidney Disease;Lung;Patient Safety;Pneumonia;Pneumonia and Influenza

ORG_CITY: DOWNERS GROVE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MIDWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative: The proposed research is relevant to public health because antibiotic resistant infections caused by Klebsiella aerogenes, Klebsiella oxytoca, Klebsiella pneumoniae, and P. aeruginosa were responsible for approximately $2 billion in attributable healthcare costs and over 12,000 deaths in 2017 alone. Nearly half of all patients who develop severe pneumonia caused by pathogens like these will experience antibiotic treatment failure and up to 30% will not survive. This proposal will advance the NIH mission to protect and improve patient health by addressing the urgent for new and innovative treatment approaches including Precision Dosing for patients infected by these pathogens.

PI_NAMEs: RHODES, NATHANIEL JAMES (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Alveolar;alveolar epithelium;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;assay development;beta-Lactams;biobank;Bronchoalveolar Lavage Fluid;Cessation of life;Clinical;clinical efficacy;Clinical Research;clinical risk;Critical Care;Critical Illness;Data;Death Rate;Development;Diagnostic;Dose;dose individualization;Drug Kinetics;drug resistant pathogen;Epithelium;Evaluation;experience;Experimental Designs;Exploratory/Developmental Grant;Focus Groups;Funding;Future;Goals;Health;Health Care Costs;high risk;Hospital Mortality;improved;individual patient;Infection;Infrastructure;Injury to Kidney;innovation;Intensive Care Units;Klebsiella aerogenes;Klebsiella oxytoca;Klebsiella pneumoniae;Knowledge;Liquid substance;Literature;Lung;Measures;Mechanical ventilation;Medicine;Meropenem;Mission;Modeling;mortality risk;Nosocomial Infections;Nosocomial pneumonia;novel;Online Systems;Outcome;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Plasma;Pneumonia;pneumonia treatment;Population;population based;predictive modeling;prospective;Pseudomonas aeruginosa;Public Health;Qualifying;Randomized, Controlled Trials;Recommendation;Regimen;Renal Replacement Therapy;Research;Research Infrastructure;response;Risk;sample collection;Sampling;Scheme;Site;Statistical Models;Systems Biology;tool;Translating;Translations;Treatment Failure;treatment optimization;United States National Institutes of Health;Universities;Validity and Reliability

PROJECT_TITLE: Development and Evaluation of CRRT-Specific Precision Dosing Models to Optimize Beta-Lactam Treatment for Patients with Hospital-Acquired Pneumonia

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: WILLIAMSON, JEFF DOUGLAS (contact)

PROJECT_TERMS: Action Research;Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;arterial stiffness;Biological Markers;biomarker identification;Biometry;Blood Vessels;Brain;cerebrovascular reactivity;Classification;Clinical;clinical database;Clinical Research;Cognitive;cohort;Cohort Studies;Consensus;Consultations;COVID-19 pandemic;Data;data exchange;data management;Dedications;Dementia;Development;Disease;Education;education research;Enrollment;Ensure;Evaluation;Faculty;Fostering;Foundations;Glucose Intolerance;glucose metabolism;glucose tolerance;Growth;health disparity;heart rate variability;high standard;Hypertension;Image;imaging biomarker;innovation;interest;lifestyle factors;Liquid substance;Magnetic Resonance Imaging;Measures;Metabolic;Mitochondria;Monitor;Multicenter Trials;Nerve Degeneration;neuroimaging;neuropathology;normal aging;older adult;operation;outreach;Participant;participant retention;Pathway interactions;Patient Recruitments;Persons;Physical activity;Positron-Emission Tomography;precision medicine;Prevalence;Prevention strategy;programs;promote resilience;Publications;recruit;Registries;relational database;Research;Research Personnel;resilience factor;Resources;Risk;Role;Sampling;Services;Sleep;Spinal Puncture;success;symposium;tau Proteins;Telephone;tool;Underrepresented Populations;Validation;Vascular Dementia;vascular factor;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Understanding changes in brain dynamics and behavior of a subject recovering from unconsciousness is critically relevant to public health and patient quality of life, particularly in brain injury and recovery from anesthesia. This proposal will determine functional neuronal connectivity maps underlying awakening in healthy and injured brains and metrics that predict and track levels of arousal and awareness by combining cortical activity and motor behavior parameters. Successful completion of this proposal will identify more precise biomarkers that improve our ability to measure forebrain arousal.

PI_NAMEs: CALDERON, DIANY PAOLA (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Affect;Anesthesia procedures;Anesthetics;Animals;Anterior;Area;Arousal;Auditory;auditory stimulus;Automobile Driving;Awareness;basal forebrain;Behavior;Behavioral;behavioral response;Biological Assay;Biological Markers;Brain;Brain Injuries;Brain Stem;Cell Nucleus;Coma;Conscious;Consciousness Disorders;COVID-19 survivors;Cues;Decerebration procedure;deep learning;Deglutition;density;Diabetic Coma;Doppler Ultrasound;Exhibits;experimental study;extracellular;Face;frontal lobe;goal oriented behavior;Goals;Head;Hour;Image;imaging system;improved;Individual;Inhalation;Injury;innovation;kinematics;Knowledge;Learning;Link;Lip structure;Maps;Measurement;Measures;Mediating;Medical;Methods;Modeling;Monitor;Motor;Motor Activity;motor behavior;Motor Cortex;Movement;Mus;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;novel;optogenetics;Pathologic;Pathway interactions;Patients;Pattern;Persons;Population;Population Dynamics;Preparation;Process;Prognosis;Prosencephalon;Public Health;Quality of life;Recovery;recruit;Reflex action;Reporting;response;restoration;Rodent;sensory stimulus;Signal Transduction;Silicon;sound;Stimulus;System;Techniques;temporal measurement;Time;tongue root;Touch sensation;Ultrasonography;Unconscious State;Wakefulness;Water;Work

PROJECT_TITLE: Mechanisms and Functions of Cortical Activity to Restore Behavior

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative In this multicenter proposal, we plan to test and validate a novel approach to hepatocellular carcinoma (HCC, the fastest growing cause of cancer death in the United States) in cirrhotic patients at risk, based on an abbreviated magnetic resonance imaging (AMRI) protocol using a liver specific MRI contrast agent (gadoxetic acid) with acquisition time <15 min, which potentially provides better detection rates of HCC, compared to the recommended ultrasound method with/without serum alpha-feto protein (AFP). We also plan to test the added value of liquid biopsy (circulating tumor DNA) measured in the blood, alone and in combination with AMRI and ultrasound for HCC screening. Additionally, we will assess the cost-effectiveness of the AMRI approach in comparison with ultrasound. Finally, we will explore the value of a dynamic AMRI protocol in comparison with ultrasound. If validated, this may benefit a large population of patients with chronic liver disease in the United States, with potential decrease in HCC-related mortality.

PI_NAMEs: BASHIR, MUSTAFA R.;REEDER, SCOTT B.;SIRLIN, CLAUDE B;TAOULI, BACHIR  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Abbreviations;Abdomen;Acids;Address;Adoption;Adult;Affect;American;Biological Markers;Blood;California;Cancer Etiology;Cessation of life;chronic liver disease;Cirrhosis;Clinical;clinical practice;contrast enhanced;Contrast Media;cost;Cost Analysis;cost effective;cost effectiveness;Darkness;Data;design;Detection;Diagnostic;diagnostic value;digital;DNA;Early Diagnosis;effective therapy;extracellular;follow-up;Future;Genetic Materials;Hepatobiliary;high risk;Image;imaging approach;improved;Injections;Ionizing radiation;Lesion;liquid biopsy;Liver;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;medical schools;Methodology;Methods;Modality;models and simulation;Morbidity - disease rate;mortality;Nodule;novel;novel strategies;Obesity;Overweight;Pathology;patient population;Patients;Performance;Phase;Practice Guidelines;Primary carcinoma of the liver cells;prospective;Prospective Studies;Proteins;Protocols documentation;Reader;Recommendation;Reference Standards;Risk;Risk Factors;screening;Sensitivity and Specificity;Serum;System;Technology;Testing;Time;tumor DNA;ultrasound;United States;Universities;Validation;Wisconsin;X-Ray Computed Tomography;α-Fetoproteins

PROJECT_TITLE: Abbreviated MRI for HCC screening in cirrhotic patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ESPELAND, MARK ANDREW (contact)

PROJECT_TERMS: Action Research;Adult;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;analytical method;Applications Grants;Archives;Automobile Driving;Bioinformatics;biomathematics;Biomedical Computing;Biometry;Blood Vessels;brain magnetic resonance imaging;Capsicum;career;Clinical Trials;Cognition;Cognitive;Collaborations;collaborative environment;Collection;Communication;Communities;Consultations;Data;Data Analyses;data exchange;data infrastructure;data library;data management;Data Management Resources;data platform;data quality;Data Reporting;data resource;Databases;Development;Education;Educational workshop;Ensure;experience;Family;Fostering;Funding;Genetic;Gerontology;Geroscience;Goals;Health Professional;Image Analysis;improved;Individual;Infrastructure;Interdisciplinary Study;Interest Group;Investments;Manuscripts;Measurement;Measures;meetings;Mentors;Metabolic;Methodology;Methods;Mission;Modeling;Multicenter Studies;novel;novel strategies;Pathogenesis;Pathway interactions;Patients;Preparation;Prevention;Prevention strategy;Productivity;programs;Protocols documentation;Publications;quality assurance;Recording of previous events;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Resources;Role;Science;Secure;Services;skills;success;therapeutic development;Training;United States National Institutes of Health;Vision;webinar;Work

PROJECT_TITLE: Data Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative:  The goal of this proposal is to develop a new swine model of pancreatic cancer to enable preclinical testing of systemically delivered oncolytic adenoviruses to detect and treat pancreatic cancer. Successful products from this proposal can be promptly translated to the clinical arena bringing novel therapeutic approaches to the patients with pancreatic cancer including those with unresectable metastatic disease. 1

PI_NAMEs: DAVYDOVA, JULIA  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Acinar Cell;Address;Adenovirus Vector;Adenoviruses;Anatomy;Animal Model;anti-cancer treatment;Binding;Biodistribution;Body Size;Bystander Effect;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;cancer therapy;canine model;carcinogenesis;CD46 Antigen;Cells;Cessation of life;Clinical;clinical development;clinical translation;Clinical Trials;clinically relevant;collaborative environment;curative treatments;Data;design;desmoglein 2;detection sensitivity;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Disadvantaged;Disease;Disseminated Malignant Neoplasm;Drug Kinetics;Duct (organ) structure;Ductal Epithelial Cell;effective therapy;Engineering;Enterobacteria phage P1 Cre recombinase;Evaluation;Excision;experience;Family suidae;Fostering;gene function;Generations;Genes;Genetic;Goals;Human;Image;Imaging technology;Immunity;Immunocompetent;immunogenicity;improved;Industrialization;Intravenous;KRAS2 gene;KRASG12D;Lesion;Malignant neoplasm of pancreas;Mediating;Metabolism;Methods;Modeling;Monitor;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;novel diagnostics;novel therapeutic intervention;Oncogenes;oncolysis;Oncolytic;oncolytic adenovirus;Operative Surgical Procedures;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathologist;Patient imaging;Patient Selection;Patients;Pattern;permissiveness;Phase I Clinical Trials;Physiology;porcine model;pre-clinical;preclinical study;Preclinical Testing;prevent;Radiation therapy;Radioactive Iodine;radioiodine imaging;radioiodine therapy;Radioisotopes;radiologist;receptor;Recording of previous events;Reporting;Rodent;Rodent Model;Safety;safety study;screening;Serotyping;single photon emission computed tomography;SLC5A5 gene;success;surgical service;Survival Rate;System;Technology;Testing;theranostics;Therapeutic;Time;Tissues;tool;Transgenic Organisms;Translating;Translations;Treatment Protocols;tumor;tumor progression;tumorigenesis;Unresectable;uptake;vector;Virus;Work;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Advancing Systematic Delivery of Oncolytic Adenovirus for Pancreatic Cancer

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative: The urothelial cells that line the bladder are tightly bound to one another by a multi-component, belt-like structure called the apical junctional complex. How this complex promotes adhesion in the face of large changes in bladder volume are unknown, but we hypothesize that it depends on the expansion and contraction of the junctional complex in response bladder filling and voiding. We further propose that the junctional complex senses tension and when bladder pressure become pathologically high (e.g., in response to benign prostatic hypertrophy) the components of the junctional complex stimulate the urothelial cells to proliferate and express abnormal amounts of regulatory proteins that contribute to further bladder dysfunction.

PI_NAMEs: APODACA, GERARD L (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Acute;Adherens Junction;Adhesions;Affect;Animal Model;Apical;Benign Prostatic Hypertrophy;Binding;Biology;Bladder;Bladder Dysfunction;Cell Line;Cell Physiology;Cell-Cell Adhesion;Cells;Complex;confocal imaging;Contracts;Coupled;Cystitis;Cytoskeleton;Data;Desmosomes;Devices;Electron Microscopy;Endocytosis;Endothelial Cells;Enterocytes;Environment;Epithelium;Event;Exocytosis;experimental study;force sensor;Functional disorder;Gene Expression;genetic regulatory protein;Global Change;Image;Image Analysis;insight;Integral Membrane Protein;Interstitial Cystitis;intravesical;Length;live cell imaging;Lower urinary tract;Mechanics;mechanotransduction;Membrane;Membrane Proteins;Microscopy;Myosin Type II;non-muscle myosin;novel;Obstruction;Organ of Corti;Pathologic;Pathology;Pathway interactions;Patients;pneumocyte;polymerization;Polymers;preservation;pressure;Process;Proliferating;Proteins;Regulation;Renal tubule structure;Reporting;response;Role;Sarcomeres;sensor;Signal Pathway;Site;Spinal cord injury;Stomach;Stretching;Structure;Testing;Tight Junctions;Time;Tissues;trafficking;ultra high resolution;Urine;Urologic Diseases;Urothelial Cell;Urothelium;Variant

PROJECT_TITLE: Role of AJC in umbrella cell function and dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


PI_NAMEs: MONTINE, THOMAS J (contact)

PROJECT_TERMS: Acceleration;Action Research;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Animal Model;Area;Biological Markers;Biological Models;biological specimen archives;Biological Specimen Banks;Blood;Blood Vessels;Brain;brain volume;Cerebrospinal Fluid;Cerebrum;Clinical;clinical center;cohort;Collaborations;Collection;Communities;Consent;Consultations;Data;data management;Data Set;Development;Diagnosis;Diagnostic;Disease;distributed data;DNA;DNA Repository;Education;education research;endophenotype;Evaluation;Fostering;Functional disorder;Goals;health disparity;Human;Individual;innovation;inter-institutional;Internet;Leadership;Liquid substance;Measurement;Measures;Mentors;Metabolic;Metabolic Diseases;Methods;Microscopy;Modeling;Molecular;Multi-Ethnic Study of Atherosclerosis;Neurodegenerative Disorders;neuropathology;next generation;nonhuman primate;normal aging;novel;novel marker;operation;Organoids;Participant;participant enrollment;Pathologic;Pathology;Pathway interactions;Procedures;programs;Protocols documentation;recruit;repository;Research;Research Personnel;Resources;Risk;Rodent;Role;sample collection;Sampling;Scientific Advances and Accomplishments;Senile Plaques;Specimen;Spinal Puncture;symposium;tau Proteins;Technology;Therapeutic Research;Therapeutic Studies;therapeutic target;tissue biomarkers;translational model;Translational Research;Underrepresented Populations;Universities;Vascular Diseases;vascular risk factor;virtual;Washington

PROJECT_TITLE: Neuropath Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: In the United States, there remains a critical need for well-trained investigators in dental, oral and craniofacial research. This training grant application supports Training in Craniofacial and Oral Health Research (T-COHR), an integrated program based in the College of Dental Medicine at the Medical University of South Carolina (MUSC) to help train the next generation of clinician scientists and scientists engaged in dental, oral and craniofacial research. Research training will be in the areas of oral infection and inflammation, oral cancer, bioengineering/biomechanics of the oral complex, and oral/craniofacial complex growth and regeneration.

PI_NAMEs: YAO, HAI  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TITLE: T-COHR: Training in Craniofacial and Oral Health Research


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because progress to ensure that all HIV-exposed infants are tested and treated as necessary has lagged and, without substantial improvements, will prevent the global community from reaching the UNAIDS 90-90-90 targets to end the AIDS epidemic by 2030. There is an urgent need for novel approaches to prompt early infant HIV testing, such as engaging social networks since they have been shown to be important in affecting other health behaviors, though not yet rigorously assessed within the context of infant HIV testing. This proposed research is directly relevant to NIH's HIV/AIDS research priorities to develop, test, and implement strategies to improve HIV testing by laying the foundations for implementing a social network intervention to ensure prompt testing and treatment for the 150,000 newly infected infants each year.

PI_NAMEs: COMFORT, ALISON B (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Affect;Africa South of the Sahara;African;Age;Age Months;AIDS prevention;Applied Research;Behavior;behavior change;Birth History;care seeking;career;Cessation of life;Characteristics;Child;cohort;Communities;Country;Data;Data Collection;design;Disclosure;econometrics;Education;Effectiveness;Ensure;Epidemic;experience;Exposure to;Family;Feasibility Studies;Focus Groups;Foundations;Goals;Grant;Health;Health behavior;HIV;HIV Infections;HIV Seropositivity;HIV/AIDS;Human immunodeficiency virus test;implementation framework;implementation science;improved;Individual;Infant;infant infection;Influentials;Infrastructure;innovation;Intervention;Interview;intimate partner violence;Investigation;Knowledge;learning network;Link;Longitudinal Studies;Maps;Measures;Medical Records;member;Mentorship;Methods;mortality;Mothers;novel;novel strategies;Nulliparity;Parents;Pathway Analysis;Pathway interactions;Pattern;peer;peer influence;peer learning;pilot test;Positioning Attribute;prevent;Public Health;Qualitative Research;Recommendation;Recording of previous events;reproductive;Research;Research Methodology;Research Personnel;Research Priority;Role;social;social engagement;social influence;Social Network;social network intervention;social norm;social stigma;Social support;Space Models;Surveys;Testing;theories;therapy design;therapy development;Training;Uganda;United States National Institutes of Health;uptake;Woman;women's prevention;women's treatment;working group

PROJECT_TITLE: Understanding individual- and social network-level factors affecting infant HIV testing to design social network interventions to increase testing of HIV-exposed infants

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We seek to construct biocompatible chemical tools that can interrogate the dynamic molecular events of living systems across space and time. By embedding highly eﬃcient reactions within 2D/3D nucleic acid scaﬀolds, we will build toolkits with the speed and sensitivity to capture the deep complexity of living cells and tissues. With architectures that can translate chemical events into new sequence information, we aim to erase boundaries between in vivo chemistry and nucleic acid biotechnologies, transforming (bio)molecular tracking and sensing.

PI_NAMEs: CARLSON, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Bioorthogonal temporospatial tools


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: BAKER, LAURA D. (contact)

PROJECT_TERMS: Address;Adult;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Black race;Blood Vessels;Brain;brain health;Cardiovascular Diseases;Caregiver support;caregiving;Catchment Area;Centers for Disease Control and Prevention (U.S.);Clinical;cohort;Collaborations;Communities;Community Healthcare;Community Outreach;community partners;Community Services;Continuing Education;County;Cultural Sensitivity;Dementia;design;Development;Diabetes Mellitus;Disease;Economics;Education;Education and Outreach;Educational Curriculum;Educational Materials;Emergency Situation;Enrollment;ethnic minority;Ethnic Origin;Ethnic Population;feasibility testing;Feedback;Foundations;Funding;Goals;Health;Health Professional;Healthcare;high risk;Hispanic;human old age (65+);Impaired cognition;Individual;information gathering;innovation;Knowledge;Label;Latinx;Life Style;Medical;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic rate;minority communities;Minority Groups;modifiable risk;Multi-Ethnic Study of Atherosclerosis;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;Not Hispanic or Latino;outreach;outreach program;Participant;participant enrollment;participant retention;Pathogenesis;Population;Prevalence;Prevention;Prevention strategy;programs;Prospective Studies;Provider;Race;racial minority;racial population;recruit;Research;Research Activity;Resources;Risk;Risk Factors;Risk Management;Risk Reduction;sobriety;social;statistics;Stroke Belt;Training Activity;treatment strategy;trustworthiness;Underrepresented Populations;underserved community;Vascular Diseases;vascular factor;vascular risk factor;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: WHITLOW, CHRISTOPHER T (contact)

PROJECT_TERMS: Acetoacetates;Action Research;Address;adjudication;advanced analytics;Affect;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;amyloid pathology;Animal Model;Animals;Area;arterial spin labeling;Biological Markers;Biometry;Blood;Blood Vessels;brain health;Brain imaging;brain magnetic resonance imaging;Cerebrovascular Disorders;cerebrovascular reactivity;Classification;Clinical;Clinical assessments;Clinical Data;Cognition;cohort;Collection;Communities;Complement;Consensus;Consultations;Cyclotrons;Data;data management;Data Management Resources;Data Set;data sharing;Dedications;Dementia;Development;Disease;Disease Progression;Doctor of Philosophy;Education;ethnic diversity;experience;Frequencies;Future;Genomics;Head;health disparity;Image;image translation;imaging biomarker;imaging facilities;imaging modality;imaging program;Impaired cognition;Individual;Infrastructure;innovation;lifestyle factors;Ligands;Magnetic Resonance Imaging;Measures;medical schools;member;Metabolic;Methods;Microtubules;mild cognitive impairment;Mission;Mitochondria;Modeling;molecular imaging;multimodal neuroimaging;Nature;Neurodegenerative Disorders;neuroimaging;neuropathology;next generation;nonhuman primate;normal aging;novel;novel strategies;Participant;participant enrollment;Pathologic;Pathology;Phase;Phenotype;Positron-Emission Tomography;Prevention strategy;Process;Production;Protocols documentation;Race;racial diversity;radiotracer;Recommendation;relational database;Research;Research Personnel;Resolution;Resources;Risk;Rodent;Role;Scientific Advances and Accomplishments;serial imaging;Slice;Spinal Puncture;Standardization;Synaptic Vesicles;targeted treatment;tau Proteins;Techniques;Therapeutic Intervention;Tracer;Training;Translational Research;treatment response;Underrepresented Populations;user-friendly;Vascular Diseases;vascular risk factor

PROJECT_TITLE: Biomarker


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Thousands of people in the United States each year suffer permanent voice loss because their voice boxes (larynges) are damaged from cancer, trauma, or nerve injury, as, in these cases, we currently have no options for restoration of normal laryngeal function. In this application, we explore novel methods for restoring function of the voice box (larynx) using adult-derived muscle and fat stem cells in a large animal model. We believe our findings will completely transform current paradigms for voice restoration in patients who have suffered severe laryngeal injuries.

PI_NAMEs: HALUM, STACEY L. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;adduct;Adult;adult stem cell;Animal Model;Animals;Aphonia;Autologous;Autopsy;Biomanufacturing;Biomedical Engineering;Biopsy;Cartilage;cartilage implant;cartilaginous;Chondrocytes;Chondrogenesis;Clinical;Collaborations;Collagen;Communication impairment;Contralateral;Cordectomy;Data;Defect;Denervation;Dysphonia;Electromyography;Engineering;Environment;experimental study;Expressed Emotion;fabrication;Family suidae;Fatty acid glycerol esters;Fiber;functional restoration;Goals;Human;Implant;implantation;improved;In Vitro;in vivo;Individual;Injury;innovation;instrument;Laryngeal Injury;Laryngeal muscle structure;Laryngectomy;Larynx;Left;Legal patent;Liquid substance;Local anesthesia;Maintenance;Malignant Neoplasms;Mechanics;Medial;Methods;Modeling;Molds;Motion;Motor;Motor Endplate;Muscle;muscle progenitor cell;muscle repair;Nerve;nerve injury;nerve supply;novel;novel strategies;Operative Surgical Procedures;Outcome;Paralysed;Patients;Pattern;Personality;Persons;Physicians;porcine model;Positioning Attribute;pressure;Property;reconstruction;Recurrent Laryngeal Nerve;repaired;Research Personnel;restoration;Rodent Model;scaffold;scale up;Scientist;self assembly;stem cells;Testing;Time;Tissue Engineering;translational model;Trauma;United States;Vial device;vocal cord;Voice

PROJECT_TITLE: Muscle progenitor cell-based implants for dynamic laryngeal muscle reconstruction

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative  The ability to predict the sensory consequences of our actions is critical for learning and maintaining many complex behaviors, including speech, as well as for normal hearing in everyday life. This proposal will investigate the neural circuitry necessary for learning to predict the anticipate and suppress the excepted acoustic consequences of our actions. This research will provide critical insights into brain mechanisms important for normal hearing and will form the basis for understanding how the brain processes phantom sounds in disorders including tinnitus and schizophrenia.

PI_NAMEs: SCHNEIDER, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Auditory;Auditory area;auditory comprehension;Auditory Hallucination;auditory pathway;Augmented Reality;Behavior;behavior change;Behavioral;Brain;brain circuitry;Calcium;Cells;Chronic;Complex;Comprehension;congenital hearing loss;design;Disease;Electrophysiology (science);expectation;experience;Experimental Models;experimental study;flexibility;Health;Hearing;hearing impairment;Hour;Human;Image;in vivo;inhibitory neuron;innovation;insight;Interneurons;Learning;learning engagement;Life;life history;Mastication;Measures;Mediating;Mission;Monitor;Motor;Motor Cortex;motor disorder;Movement;Mus;Music;Nervous System;neural;neural circuit;neuronal circuitry;Neurons;normal hearing;optogenetics;Outcome;Pathology;Persons;pharmacologic;Physiological;Physiology;Play;Presynaptic Terminals;Process;programs;recruit;Research;response;Role;Schizophrenia;Sensory;Shapes;Signal Transduction;Site;skills;Songbirds;sound;Speech;System;Techniques;Testing;Tinnitus;tool;Training;two-photon;United States National Institutes of Health;vocalization;Walking

PROJECT_TITLE: Auditory cortical processing of self-generated sounds

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Action Research;Address;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Basic Science;Biological Markers;Brain imaging;Capsicum;career;career development;Clinical;Clinical Sciences;Cognitive aging;cognitive testing;Collaborations;Competence;Development;Discipline;Diverse Workforce;Education;education research;Educational Curriculum;Educational workshop;Ensure;Etiology;experience;Faculty;faculty research;Fostering;Foundations;Funding;Geriatrics;Gerontology;Goals;graduate school;graduate student;Grant;healthy aging;Image Analysis;Institution;instructor;interest;Journals;Knowledge;Leadership;Measurement;member;Mentors;Mentorship;Metabolic;mid-career faculty;mild cognitive impairment;Modeling;Multi-site clinical study;multidisciplinary;next generation;nonhuman primate;older adult;Pathogenesis;Pathologic;Postdoctoral Fellow;Prevention;Principal Investigator;professor;programs;Recording of previous events;recruit;Research;research and development;Research Personnel;Research Project Summaries;Resources;Rodent;Scholars Program;Science;Scientist;skills;student training;symposium;synergism;Training;Training and Education;Training Programs;Training Support;translational impact;Translational Research;undergraduate student;Underrepresented Populations;United States National Institutes of Health;vascular risk factor;Work;Writing

PROJECT_TITLE: REC Core


NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The objective of this proposal is to understand the local and global changes in somatosensory circuits that occur after focal cortical lesions. Knowledge of these basic mechanisms of plasticity after injury will inform future translational studies targeted toward promoting recovery of function.

PI_NAMEs: ZEIGER, WILLIAM ABEL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Ablation;Animal Model;Animals;Area;Atlases;axonal sprouting;Behavioral;Biological Models;Brain;Brain Mapping;Brain region;Calcium;California;career;career development;Cell Shape;Cells;Central Nervous System;Clinical Sciences;Communities;Complex;Control Animal;Dendritic Spines;designer receptors exclusively activated by designer drugs;Development;Development Plans;disability;discrimination task;Equilibrium;Etiology;Exhibits;experience;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gene Expression;Global Change;Goals;Human;human model;Image;Imaging Techniques;Impairment;improved;in vivo;in vivo calcium imaging;Individual;Injury;insight;Institution;Interneurons;Knowledge;Label;Learning;Lesion;Light;Los Angeles;Maps;Measures;Mediating;Mentors;Methods;mouse model;Movement Disorders;Mus;Nervous System Disorder;Nervous System Trauma;neural circuit;Neurology;neuronal circuitry;Neurons;neuroregulation;Neurosciences;novel;Parvalbumins;Pathologic;Pathologic Processes;Physicians;Play;Positron-Emission Tomography;post stroke;professor;Pyramidal Cells;Recovery;Recovery of Function;Research;Research Personnel;Resolution;Resources;response;Role;Scientist;Sensory;sensory cortex;sensory discrimination;Shapes;Site;somatosensory;Somatosensory Cortex;Stroke;stroke model;Technical Expertise;Testing;Therapeutic;Time;Tissues;Translational Research;translational study;two-photon;Universities;Vibrissae;whisker discrimination;Work

PROJECT_TITLE: Mechanisms of Somatosensory Circuit Remapping After Cortical Injury in Mice

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Organ Transplantation;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed project will generate new knowledge of the magnitude and mediators of inequities at each phase of the transplant selection process and how institutional racism embedded in center-level processes and individual clinician biases may influence inequities. The results will elucidate the influence of institutional racism in transplant systems and processes on racial equity in access to transplant. In the future, Our toolkit will represent the first intervention developed to overcome bias and mitigate inequities at each step in the transplant selection process. In the future, we hope implement our toolkit at multiple transplant centers to test its ability to mitigate institutionally biased practices which contribute to organ transplant inequities.

PI_NAMEs: MCELROY, LISA M (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: acceptability and feasibility;access disparities;Attention;black patient;Black race;Cessation of life;Clinical;clinical application;clinical decision-making;clinical practice;Cross-Sectional Studies;Data;Data Collection;Decision Making;design;Diagnostic tests;Disease;Disparity;Educational Status;Electronic Health Record;Equity;ethnic minority;Ethnic Origin;Evaluation;Exclusion;Focus Groups;Foundations;Funding;Future;Gender;Geography;Goals;Health system;improved;Income;Individual;Inequity;Institution;Institutional Racism;Insurance Coverage;Intervention;Intervention Studies;Knowledge;Measures;Mediator;Medicine;meetings;Mentors;Methods;Monitor;multidisciplinary;Nurses;Operative Surgical Procedures;optimal treatments;Organ;organ transplant recipient;Organ Transplantation;Outpatients;patient screening;Patients;Persons;Phase;Process;Quality of life;Race;racial bias;racial disparity;Racial Equity;racial minority;Research;Research Personnel;screening;skill acquisition;social health determinants;Social Work;Standardization;Surveys;System;Testing;tool;Training;transplant centers;Transplant Recipients;Transplantation;Transportation;United States;Waiting Lists;Work

PROJECT_TITLE: Improving Racial Equity in Clinical Decision Making about Access to Organ Transplant


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative (Public Health Relevance) This project will develop explainable and stable machine learning solutions for psychiatric brain stimulation. The pro- posed approach aims to discover how targeted stimulation drives changes in network dynamics and connectivity at a large scale and across multiple brain areas. As such, it will result in the design of AI-guided neuro-stimulation that can modulate and improve higher cognitive function, such as working memory, attention, and executive control.

PI_NAMEs: HARCHAOUI, ZAID  (contact);YAZDAN SHAHMORAD, AZADEH

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Adoption;Animal Behavior;Animals;Area;Artificial Intelligence;attentional control;Beds;Behavior;Biomedical Engineering;Biometry;Brain;cell type;Clinical;Cognitive;cognitive ability;cognitive function;cognitive task;Compensation;Complex;Computer Models;Cues;Data;Decision Making;design;Electrocorticogram;Engineering;executive function;experimental study;explainable machine learning;flexibility;functional plasticity;Genes;Goals;Graph;improved;in vivo;insight;Intervention;Lead;Learning;Light;Long-Term Effects;Machine Learning;machine learning model;Maps;Mental disorders;Methods;Modeling;Nervous System Disorder;network models;neural;neural circuit;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;nonhuman primate;novel;open source;optogenetics;Outcome;Pattern;Performance;Personality;Prefrontal Cortex;Process;Property;Proteins;public health relevance;Research Personnel;response;Response to stimulus physiology;Rewards;Role;Science;Short-Term Memory;Social Behavior;Software Tools;stem;Structure;Testing;Therapeutic;Time;tool;Update;Validation;Virus;Visual;visual stimulus;Writing

PROJECT_TITLE: Explainable Machine Learning to Guide Prefrontal Brain Stimulation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vector-Borne Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Plasmodium falciparum malaria remains a major public health problem globally, and new approaches to malaria control and prevention are urgently needed. In this proposal we will comprehensively determine the function of two newly-discovered human red blood cell host factors for malaria, testing the hypothesis that they facilitate parasite invasion through distinct yet synergistic pathways that are critical for the parasite’s life cycle. This project will advance our fundamental understanding of red blood cell-parasite interactions, and lay the groundwork for the development of host-directed therapies for malaria.

PI_NAMEs: EGAN, ELIZABETH S. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Anti-malarials;Antibodies;Avidity;Binding;Biological Assay;candidate identification;CD44 gene;Cell surface;Cell Surface Receptors;Cells;Cellular biology;Cessation of life;Child;Communicable Diseases;comparative;Complex;CRISPR/Cas technology;Critical Pathways;Cytoskeleton;Data;Dependence;Development;DNA;Drug resistance;Erythrocytes;Experimental Genetics;experimental study;Falciparum Malaria;Genetic Engineering;Genetic Screening;genome editing;Goals;Hematopoietic stem cells;HIV;Human;human stem cells;imaging platform;Individual;Infection;Influenza;insight;Integration Host Factors;Intervention;Invaded;Knowledge;Label;Leishmania;Life Cycle Stages;Ligands;live cell imaging;Malaria;Mass Spectrum Analysis;Mediating;Methods;Microscopy;Morbidity - disease rate;mortality;mutant;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;novel vaccines;obligate intracellular parasite;Organelles;Paper;parasite invasion;Parasites;pharmacologic;phosphoproteomics;Plasmodium;Plasmodium falciparum;Play;Post-Translational Protein Processing;Pregnant Women;Prevention;Process;protein protein interaction;Proteins;Proteomics;Public Health;Publishing;receptor;Recombinants;Resistance;rhoptry;Role;Signal Pathway;Signal Transduction;Source;stem cells;Surface;Testing;Therapeutic;Vaccines;Work

PROJECT_TITLE: Elucidating the functions of red blood cell factors in malaria parasite invasion

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: It is estimated that 69 million people suffer a traumatic brain injury (TBI) on an annual basis and many of these individuals will go on to develop post-traumatic headache (PTH) that can lead to persistent post-traumatic headache (PPTH). Such headaches are extremely difficult to treat, and new, effective non-opioid medications are urgently needed. Our studies are aimed to increase understanding of PTH and transition to PPTH in order to improve therapies for patients.

PI_NAMEs: ANDERSON, TRENT ;NAVRATILOVA, EDITA ;PORRECA, FRANK  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Address;allodynia;Animals;Behavioral;Biomechanics;Blood;Botox;Brain Concussion;Calcitonin Gene-Related Peptide;Cells;central sensitization;Cephalic;Clinical;clinically relevant;Common Migraine;Conscious;cranium;Data;Development;Disabling;Drops;Electrophysiology (science);Equilibrium;Event;Evidence based treatment;experience;Female;Functional disorder;Goals;guided inquiry;Headache;Impairment;improved;Individual;Injury;Knowledge;Laboratories;male;Memory;Meningeal;Methods;Migraine;mild traumatic brain injury;Modeling;Monoclonal Antibodies;Motor;Mus;neurochemistry;Neurons;neuropathology;Nociceptive Stimulus;Nociceptors;non-opioid analgesic;novel;novel therapeutics;Outcome;Pain;pain chronification;Pathogenesis;Patient-Focused Outcomes;Patients;Peptide antibodies;Peripheral;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Post-Traumatic Headaches;prevent;Property;Recording of previous events;Residual state;Resistance;Resolution;Risk Factors;Role;Running;Severities;Skull Fractures;Spreading Cortical Depression;Stimulus;Stress;Symptoms;Therapeutic;Toxin;Traumatic Brain Injury;treatment strategy;Trigeminal Nuclei;Unconscious State;Weight

PROJECT_TITLE: Mechanisms and Therapeutic Strategies for Post-traumatic Headache

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_DEPT: PSYCHIATRY

PHR: NARRATIVE / PUBLIC HEALTH RELEVANCE Cognitive deficits are the main cause of disability in schizophrenia. Here we will study how specific patterns of rhythmic electrical activity in the brain can be targeted to improve cognition deficits associated with schizophrenia. This will aid in the development of new treatments for those cognitive deficits.

PI_NAMEs: SOHAL, VIKAAS SINGH (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;Affect;Anatomy;Automobile Driving;Biological;Brain;Calcium;cell type;Chemosensitization;Cognition;Cognitive;Cognitive deficits;cognitive task;Contralateral;Development;disability;Disease;Electrophysiology (science);Evolution;Frequencies;Functional disorder;Genetic;hippocampal pyramidal neuron;Histologic;Image;improved;in vivo;information processing;Interneurons;Intervention;Left;Link;Mediator;Mental Depression;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Neurons;neuropsychiatric disorder;optogenetics;Parvalbumins;Pattern;Periodicity;Pharmacology;Phase;Physiological;Physiological Processes;Physiology;Postdoctoral Fellow;postsynaptic;Prefrontal Cortex;presynaptic neurons;prevent;Property;public health relevance;Publishing;recruit;remediation;Schizophrenia;Slice;Synapses;Task Performances;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy development;voltage;Work

PROJECT_TITLE: Improving cognition by understanding and harnessing the plasticity of gamma-generating circuits in prefrontal cortex

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Human Fetal Tissue;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) is one of the most detrimental outcomes of COVID-19 infection and is believed to arise due to a cytokine storm that unleashes a cascade of unchecked inflammatory responses. The purpose of this proposal is to understand the role of the inflammasome, which causes IL-1β release and inflammatory cell death, during this process.

PI_NAMEs: KOLLER, BEVERLY H;TING, JENNY P (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Agonist;airway epithelium;Alveolar;anakinra;Apoptosis;Binding;Biological Markers;CASP1 gene;Caspase;Cell Death;cell injury;Cells;Cessation of life;chemokine;Clinical Trials;Coculture Techniques;Complex;Conflict (Psychology);COVID-19;COVID-19 pandemic;COVID-19 patient;cytokine;cytokine release syndrome;Dangerousness;Data;design;Deterioration;Epithelial Cells;Genes;Genetic Transcription;Human;IL18 gene;Immune;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-1;Interleukin-1 beta;interleukin-1beta-converting enzyme inhibitor;Interleukin-6;Lavage;Leukocytes;marenostrin;member;Meta-Analysis;Molecular;mortality;Mus;Myeloid Cells;Outcome;pathogen;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phase;Post-Translational Protein Processing;Potassium;Process;Production;Proteins;randomized, clinical trials;receptor;Reporting;response;Role;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;sensor;Severe Acute Respiratory Syndrome;severe COVID-19;Signal Transduction;single-cell RNA sequencing;standard care;Stromal Cells;Structure;Structure of parenchyma of lung;success;Testing;therapeutic target;therapeutically effective;thrombotic;TNF gene;Urokinase Plasminogen Activator Receptor;Virus

PROJECT_TITLE: Role and Mitigation of Inflammasomes and Inflammation During COVID-19

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Cancer

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal describes a new NCI-supported postdoctoral Biobehavioral Oncology Training (BBOT) Program with a cross cutting theme of cancer disparities. This transdisciplinary training program in the biobehavioral aspects of cancer prevention, control and treatment response addresses 1) the biology of stress and disparities and 2) social determinants of health, behavior, and outcomes. Through outstanding mentorship, research, and training experiences, the goal of the BBOT Program is to prepare the next generation of biobehavioral oncology researchers for successful research careers devoted to ameliorating disparities in cancer health outcomes.

PI_NAMEs: KNIGHT, JENNIFER MARY;STOLLEY, MELINDA R (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: biobehavior;Oncology;Training Programs

PROJECT_TITLE: Biobehavioral Oncology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Spousal bereavement increases the risk for developing Alzheimer’s disease and related dementias (ADRD). The proposed study aims to examine psychological, immunological, and neurobiological mechanisms that contribute to elevated ADRD risk. By examining biobehavioral pathways by which spousal bereavement confers risk for poor cognitive function and cortical thinning in signature AD regions, this study will (a) enhance scientific understanding of how psychological stress impacts cognitive function and structural brain integrity (b) help identify at-risk widow(er)s years before ADRD onset, and (c) inform the development of individualized interventions targeted at delaying or preventing ADRD onset.

PI_NAMEs: WU-CHUNG, E. LYDIA (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Adult;age related;age related changes;age-related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amygdaloid structure;Amyloid;angular gyrus;associated symptom;Atlases;Bereavement;biobehavior;Biological Assay;Biological Markers;biopsychosocial;Blood;Brain;brain abnormalities;brain morphology;Brain region;Cause of Death;Cessation of life;Chronic stress;Cognition;Cognitive;cognitive function;cognitive testing;dementia risk;depressive symptoms;Development;Disease;disease diagnosis;Distress;Early identification;entorhinal cortex;Event;executive function;Exhibits;Exposure to;Functional disorder;Funding;Future;General Population;gray matter;high risk;Hippocampus;Human body;Immune;immune function;Immunologics;Impaired cognition;Impairment;improved;Incidence;Individual;Inflammation;Inflammatory;interest;Interleukin-6;Intervention;Knowledge;Life;Link;Magnetic Resonance Imaging;Measurement;Measures;Memory;Mental Depression;Mental Health;Methods;mild cognitive impairment;Modeling;MRI Scans;multimodality;Nerve Degeneration;neurobiological mechanism;Neurobiology;neuroimaging marker;Neuroimmune;neuroinflammation;neuropathology;Onset of illness;Outcome;parent grant;Pathology;Pathway interactions;Patient Self-Report;Patients;Pattern;Peripheral;Pharmaceutical Preparations;physical conditioning;Physiological;Prevalence;prevent;Process;prospective;psychobiologic;psychologic;Psychological Stress;Regional Disease;Research;Research Design;Research Personnel;Risk;Risk Factors;Severities;Severity of illness;Stimulus;Stress;Stressful Event;stressor;Structure of inferior temporal gyrus;Symptoms;systemic inflammatory response;tau Proteins;tau-1;Thick;Thinness;TNF gene;Venous;Widow;Work

PROJECT_TITLE: From stress to dementia risk: An examination of psychological, immunological, and neurobiological mechanisms underlying increased risk for Alzheimer’s disease and related dementias in widow(er)s


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PHR: 8. Project Narrative The proposed research is relevant to public health because it will greatly improve the performance of MRI scanners to image metabolic alterations in primary brain tumors. The new imaging methods will be used to guide intra-operatively surgical resection of brain tumors and monitor treatment response. This will enable precision oncology with targeted therapy tailored to the individual patient. Hence, this research is relevant to NCI’s mission to advance diagnosis and treatment of cancer.

PI_NAMEs: ANDRONESI, OVIDIU C (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 19q;Acceleration;Address;Adjuvant Therapy;anatomic imaging;Anatomy;Biological Assay;Biopsy;Brain;brain tumor resection;cancer imaging;cancer therapy;Central Nervous System Neoplasms;chemoradiation;Classification;Clinical;clinical translation;Clinical Trials;Computer software;Consensus;cost effective;Cystathionine;Data Analyses;data quality;deep learning;deep learning model;Detection;Development;Diagnosis;Epigenetic Process;Excision;fluorescence-guided surgery;Gene Expression;Glioma;Glutamates;Glutamine;Glycine;Goals;Grant;Hybrids;Image;image guided therapy;Image-Guided Surgery;Imaging Device;imaging modality;Immune system;Immunotherapy;improved;improved outcome;in vivo;in vivo imaging;Individual;individual patient;individualized medicine;innovation;Intervention;Isocitrate Dehydrogenase;Label;Life;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;metabolomics;Methods;Mission;Modality;Molecular;molecular imaging;molecular marker;molecular pathology;Monitor;Multiparametric Analysis;multiparametric imaging;mutant;Mutation;neuro-oncology;Neuronavigation;Neurosurgeon;new therapeutic target;Nicotinamide adenine dinucleotide;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Operative Surgical Procedures;optimal treatments;Outcome;patient stratification;Patients;Performance;pharmacologic;Phosphorus;Phosphorylation;Positron-Emission Tomography;precision oncology;prevent;Primary Brain Neoplasms;Progression-Free Survivals;Protons;Public Health;Quality of life;Radiation;reconstruction;Relapse;Reporting;Research;Resistance;Resolution;response;Role;Sampling Biases;Scanning;Sensitivity and Specificity;SKIL gene;Specificity;Survival Rate;targeted treatment;Techniques;Testing;Time;Tracer;treatment planning;treatment response;tumor;tumor progression;ward;Work;World Health Organization

PROJECT_TITLE: Development of multinuclear MRI for image guided therapy of glioma patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Narrative The U.S. has set a goal to end the HIV epidemic by the year 2030, which can be achieved but only if targeted approaches are implemented with at-risk populations to address known barriers of engagement along the HIV prevention and care continua. The proposed research will inform efforts to reduce HIV/STI risk and transmission, reduce HIV/AIDS disease progression, reduce drug use and mental health co-morbidities, and improve the health and quality of life of HIV+ among at-risk youth.

PI_NAMEs: GOLDBACH, JEREMY THOMAS;KIPKE, MICHELE D. (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Accounting;Address;Adherence;Administrative Supplement;adolescent drug use;African American;Age;Age Years;AIDS prevention;American;anxious;Award;Awareness;barrier to care;Black race;care systems;Caring;children of color;cohort;Collaborations;community organizations;comorbidity;Data;Data Collection;Development;Disease Progression;Drug Screening;drug testing;Drug usage;early childhood;early-career faculty;Epidemic;Ethnic Origin;experience;follow-up;food insecurity;Fright;gender minority;gender minority youth;gender nonconforming;Goals;Grant;Health;Healthcare;high risk;HIV;HIV disparities;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Immigration;improved;Infection;infection risk;innovation;interest;Interview;Latino;Latinx;Los Angeles;Major Depressive Disorder;marginalization;marijuana use;men of color;Mental disorders;Mental Health;Methods;multi-racial;National Institute of Drug Abuse;nonbinary;Participant;Patient Self-Report;Pediatric Hospitals;Pharmaceutical Preparations;Plasma;Policy Maker;poor health outcome;Population;Populations at Risk;pre-exposure prophylaxis;prevent;prevention service;Process;psychiatric comorbidity;Quality of life;recruit;Rectum;Reporting;Research;Research Methodology;Research Personnel;Resources;retention rate;Risk;sexual minority;Sexually Transmitted Diseases;social stigma;stem;Surveys;Swab;Testing;Time;transgender;translational pipeline;transmission process;uptake;Work;young adult;young man;young men who have sex with men;Youth

PROJECT_TITLE: Using Longitudinal Research to Engage African American and Latinx Sexual- and Gender-Minority Youth in the HIV Prevention and Care Continua and Reduce HIV/AIDS-Related Disparities


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and results in nearly 700,000 hospitalizations and over $70 billion in direct medical costs annually. Although COPD is a heterogeneous disorder affecting organ systems beyond the lungs, treatment approaches remain largely similar for most patients and have not advanced significantly over the past two decades. An improved understanding of the metabolic profiles associated with specific COPD features has the potential to open up new treatment pathways for patients.

PI_NAMEs: LABAKI, WASSIM W (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Accounting;Achievement;Affect;Aftercare;Amino Acids;Award;Bioinformatics;Biological;Biological Assay;Biometry;Body Composition;Body System;Cachexia;career development;Cause of Death;Cells;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cohort;Complement;cost;Data;detection platform;Development;dietary;disability;Disease;disease heterogeneity;disease phenotype;Disease Progression;Educational workshop;Energy Intake;Energy Metabolism;Environment;Exertion;experience;Fatty Acids;Female;follow-up;Frequencies;Funding;Future;Goals;Heterogeneity;Hormonal;Hospitalization;Host Defense;Immune;immunoregulation;improved;Incidence;Inflammation;inflammatory marker;Infrastructure;insight;Institution;Investigation;Knowledge;Kynurenine;Laboratories;Lead;Liquid substance;Lung;Lung Diseases;Lung volume reduction surgery;male;Measures;Medical Care Costs;Medicine;Mentors;Metabolic;Metabolic Pathway;metabolic profile;Metabolic syndrome;Metabolism;metabolome;metabolomics;metabolomics resource;Methods;Michigan;Molecular Profiling;Molecular Weight;Morbidity - disease rate;mortality;mortality risk;Musculoskeletal System;neutrophil;new therapeutic target;novel therapeutic intervention;Nuclear Magnetic Resonance;Operative Surgical Procedures;Osteoporosis;Outcome;Overweight;Participant;Pathogenesis;Pathway interactions;patient oriented;Patients;Pattern;Phenotype;Physical Function;Physicians;Positioning Attribute;precision medicine;Protein Biosynthesis;Public Health Schools;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonology;Radiology Specialty;Research;respiratory;Risk Factors;Sampling;sarcopenia;Scientist;Serum;skills;symposium;Symptoms;Systems Biology;Techniques;Technology;Tissues;Training;translational scientist;Tryptophan;United States;United States National Institutes of Health;Universities;validation studies;Work

PROJECT_TITLE: Leveraging Serum Metabolomics to Understand Clinical Phenotypes in COPD

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Nicotine use and misuse from smoking combustible tobacco reflects a major health problem with an estimated annual economic cost around $400 billion; some of the vulnerabilities and health consequences are greater in women. The potential individual and societal benefits that would come from a better understanding of factors contributing to chronic tobacco use are enormous. This benefit drives the long-term goal of our research program to understand how nicotine accrues additional reinforcing value through conditioning processes, identify factors that exacerbate or blunt the enhanced nicotine use caused by this conditioning history, and determine the role of sex as a biological variable.

PI_NAMEs: BEVINS, RICK A (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Address;Alcohols;Association Learning;Basic Science;Biological;Biology;Chronic;Clinical;combustible tobacco;conditioning;Desire for food;Development;Dose;drug abstinence;drug seeking behavior;economic cost;electronic liquid;Environmental Risk Factor;Failure;Female;forgetting;Foundations;Friends;Goals;Health;Health Personnel;Heart Diseases;Heart Rate;improved;Incubated;Individual;innovation;Intake;interest;Intravenous;Learning;Literature;Location;male;Malignant Neoplasms;men;Methodology;Nicotine;nicotine cessation;Nicotine Dependence;nicotine replacement;nicotine self-administration;nicotine use;Nicotine Use Disorder;novel strategies;Outcome;peer;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;prevent;Process;programs;Rattus;Recording of previous events;reinforcer;Relapse;Research;Research Personnel;Rewards;Rodent;Role;Science;Scientific Advances and Accomplishments;Scientist;Self Administration;sex;sex as a biological variable;Sex Differences;Smell Perception;Smoker;Smoking;Societies;sociocultural determinant;Stimulus;Stress;Sucrose;Taste Perception;Testing;Theoretical model;Time;Tobacco;Tobacco use;Translating;vaper;vaping;visual stimulus;Woman;Work

PROJECT_TITLE: Understanding and mitigating exacerbated nicotine use resulting from Pavlovianinteroceptive conditioning

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Kidney Disease;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research will evaluate dysregulation of the alternative pathway (AP) of complement in patients with CKD. We will measure biomarkers and functional assays of the AP in participants of NEPHRON-D and SPRINT and evaluate if biomarkers of AP activation predict adverse outcomes in CKD. Additionally, we will evaluate genetic variants of the AP of complement as a potential contributing mechanism to AP dysregulation in CKD.

PI_NAMEs: JALAL, DIANA I (contact);SMITH, RICHARD J.H.;THURMAN, JOSHUA M

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Adipocytes;adverse outcome;Affect;African American population;Albuminuria;Alternative Complement Pathway;Biological Assay;Biological Markers;blood pressure intervention;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Cessation of life;Chronic Disease;Chronic Kidney Failure;clinical development;Clinical Trials;Complement;Complement Factor B;Complement Factor D;Complement Factor H;Data;Diabetes Mellitus;Disease Progression;End stage renal failure;endothelial dysfunction;Endothelium;Enzyme-Linked Immunosorbent Assay;experimental study;Future;gene complementation;Generations;Genes;Genetic Polymorphism;Genetic Predisposition to Disease;genetic variant;Glomerular Filtration Rate;Hemolytic-Uremic Syndrome;high risk;Impairment;in vivo;Individual;Inflammation;inhibitor;inhibitor therapy;Injury;Intervention Trial;Kidney;Kidney Diseases;Link;Measures;Mediating;Mediator;Membrane;meter;Morbidity - disease rate;mortality;Mutation;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;particle;Pathway interactions;patient population;Patients;Plasma;Play;Population;Positioning Attribute;pre-clinical;predictive marker;Predisposition;Proteome;rare variant;Regulator Genes;Reproducibility;Research;response;Risk Factors;Role;Sampling;Serine Protease;Signal Transduction;Subgroup;Susceptibility Gene;Testing;Time;translational potential;United States Department of Veterans Affairs;Vascular Diseases;Vesicle

PROJECT_TITLE: The Alternative Pathway of Complement: A Potential Contributor to Adverse Outcomes in CKD

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]