ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Public Health Relevance The clinical development of antibiotics has led to unprecedented medical successes over the last century. However, despite these advances, bacteria-related infections remain a serious public health concern. Approximately 35,000 patients die every year in the United States alone. With the rare properties to both kill bacteria and potentially neutralize endotoxins in addition to overcoming common bacterial drug resistance mechanisms, AMP-based cationic peptide antibiotics (PAX) with properly optimized structures for systemic efficacy would constitute an effective therapeutic option for the treatment of MDR-related infections. We propose that PAX optimization can effectively overcome changes in lipopolysaccharide (LPS) or lipid A (a submolecular component of LPS) that confer resistance to AMPs, including bacterial resistance to the membrane-active cyclic lipopeptide colistin used as a drug of last resort against MDR gram-negative bacteria (GNB). Elucidating the molecular determinants for iterative PAX design will inform PAX optimization to overcome bacterial resistance. This proposal is a logical progression toward our long-term vision to turn PAX into an effective class of AMP therapeutics that can be designed and re-designed in response to clinical challenges.

PI_NAMEs: DESLOUCHES, BERTHONY  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Affinity;Amino Acids;Animal Model;Anti-Bacterial Agents;anti-microbial drug;anti-microbial peptide;antibiotic design;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial;Antimicrobial Effect;Antimicrobial Resistance;Bacteremia;Bacteria;Bacterial Drug Resistance;bacterial resistance;bactericide;Biophysics;cell type;Charge;Circular Dichroism;Circulation;Clinical;clinical development;Clinical Research;clinically significant;Colistin;colistin resistance;Cytolysis;cytotoxic;Data;defined contribution;design;Development;Dose;emerging antibiotic resistance;Endotoxins;Engineering;Erythrocytes;experimental study;Genetic;Goals;Gram-Negative Bacteria;Hydrophobicity;immunogenicity;In Vitro;in vitro activity;in vivo;indexing;Infection;infectious disease treatment;intraperitoneal;Intravenous;Investigation;iterative design;Lead;lead candidate;Length;Leukocytes;Libraries;Lipid A;Lipopolysaccharides;Mammalian Cell;Maximum Tolerated Dose;Measures;Medical;Membrane;Minimum Inhibitory Concentration measurement;Modeling;Molecular;Multi-Drug Resistance;multi-drug resistant pathogen;multidrug-resistant Pseudomonas aeruginosa;Multiple Bacterial Drug Resistance;multiple drug use;Mus;novel;Outcome;Patients;Peptide Antibiotics;peptide drug;Peptide Library;Peptides;Periodicity;Pharmaceutical Preparations;Phase II Clinical Trials;phosphoethanolamine;preclinical study;Predisposition;Prevalence;Property;Pseudomonas aeruginosa infection;Public Health;public health relevance;rational design;rational function;Research Personnel;Resistance;Resistance development;resistance frequency;resistance mechanism;resistant Klebsiella pneumoniae;resistant strain;response;Safety;Serial Passage;Series;structural determinants;Structure;success;Surface Plasmon Resonance;Testing;Therapeutic;Therapeutic Index;Therapeutic Uses;therapeutically effective;Thinking;Time;Toxic effect;Toxicology;United States;Variant;Work

PROJECT_TITLE: Structural determinants of activity and mechanism of cationic peptide antibiotic activity against colistin-resistant bacteria

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Medulloblastoma (MB) is the most common malignant childhood brain tumor, which accounts for large number of childhood cancer deaths. Despite the progress in treating MB, the 5-year survival rate for high-risk MB remains poor with high recurrence. These is a significant need to identify novel targets that treat the MB effectively with less side effects. We discover that RNA demethylase ALKBH5 may play an important role in MB growth and progression and therefore may serve as a novel therapeutic target.

PI_NAMEs: SUBBARAYALU, PANNEERDOSS  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;aerobic glycolysis;Age;Animal Model;Binding Proteins;Biochemical;Biological Assay;Brain Neoplasms;c-myc Genes;Cancer Patient;cancer stem cell;Carbohydrates;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Central Nervous System;Cerebrospinal Fluid;Cessation of life;chemotherapy;Child;childhood cancer mortality;Childhood Malignant Brain Tumor;Clinical;conventional therapy;Dependence;Elements;Energy Metabolism;Enzymes;Epigenetic Process;experience;experimental study;gain of function;Genes;Growth;high risk;in vivo Model;knock-down;Knockout Mice;Leptomeninges;lipid biosynthesis;loss of function;Maintenance;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant Neoplasms;Medulloblastoma;medulloblastoma cell line;Metabolic;Metastatic Neoplasm to the Leptomeninges;migration;Modeling;neoplastic cell;new therapeutic target;novel;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Play;Positioning Attribute;programs;Proliferating;promoter;Proto-Oncogene Proteins c-myc;Quality of life;Radiation;Radiation exposure;radiation resistance;radiation response;radioresistant;Radiosensitization;Recurrence;Relapse;Reporting;Resistance;response;RNA;Role;self-renewal;side effect;Signal Transduction;Source;Spinal;stem cell biomarkers;stem cell proliferation;stem cell self renewal;stem cell survival;stem cells;stemness;Survival Rate;Testing;Therapeutic;therapeutic target;Toxic effect;treatment response;tumor;tumor initiation;tumor xenograft;Vincristine;Xenograft Model

PROJECT_TITLE: Targeting the RNA modifying enzyme ALKBH5 in Medulloblastoma

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed study will evaluate whether offering Somali women the opportunity to collect their own samples for HPV testing in primary care clinics is an effective strategy for increasing cervical cancer screening participation. Identifying effective and sustainable implementation strategies for HPV self-sampling in primary care could reduce disparities in cervical cancer screening among Somali patients. Findings may be transferable to other immigrant and minority groups facing similar disparities.

PI_NAMEs: PRATT, REBEKAH J. (contact);WINER, RACHEL L.

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;aged;Appointment;Area;Awareness;Cervical;Cervical Cancer Screening;Clinic;Communities;Community Health Aides;Consolidated Framework for Implementation Research;design;Development;Diagnosis;Disparity;disparity reduction;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation hybrid;Female;Focus Groups;Guidelines;Health Care Costs;health disparity;health literacy;Health Personnel;Home;HPV screening;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hybrids;Immigrant;implementation evaluation;implementation science;implementation strategy;Incidence;informant;Insurance Coverage;Intervention;intervention refinement;Interview;Koreans;Latino;Lesion;Male Circumcision;Malignant neoplasm of cervix uteri;Medical;Methods;Minority Groups;Modality;mortality;novel strategies;Nurses;Pap smear;patient oriented;patient population;Patients;Physicians;Population;Positioning Attribute;post implementation;post intervention;premalignant;prevent;Prevention;Preventive healthcare;Primary Care;primary care clinic;primary care setting;Process;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Religious Belief;Research;Sampling;screening;screening disparities;screening participation;Self Efficacy;skills;social cognitive theory;System;system-level barriers;Testing;Time;treatment as usual;United States Preventative Services Task Force;uptake;Woman;Work

PROJECT_TITLE: Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Mutant p53 protein accumulation and MDM2B overexpression in cancer play critical roles in tumorigenesis. Currently, the mechanisms underlying mutant p53 accumulation in cancer and the tumor-promoting function of MDM2B are poorly understood. This proposed study aims to determine the role and mechanism of MDM2B in promoting mutant p53 accumulation and gain- of-function in tumorigenesis, and reveal the mechanism of MDM2B overexpression in cancer, which is crucial for the development of novel therapeutic targets and strategies for cancer carrying mutant p53.

PI_NAMEs: FENG, ZHAOHUI  (contact)

PROJECT_TERMS: BAG2 gene;cancer cell;cancer diagnosis;cancer therapy;Cessation of life;Clinic;Clinical;Colon;colon cancer patients;colon tumorigenesis;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Complex;Cytoplasm;Development;Feedback;Frequencies;gain of function;Genes;Goals;Human;improved;Malignant Neoplasms;MDM2 gene;Mediating;Modeling;Molecular;mouse model;mRNA Translation;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;Oncogenic;overexpression;Pathway interactions;Phosphorylation;Play;Prognosis;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;Regulation;RNA Splicing;Role;Signal Pathway;Signal Transduction;Specimen;Spliceosomes;targeted treatment;Testing;Therapeutic;therapeutically effective;TP53 gene;Transgenic Mice;treatment response;tumor;Tumor Promotion;tumorigenesis;Ubiquitination;United States

PROJECT_TITLE: The regulation of mutant p53 protein accumulation in cancer: molecular basis and therapeutic potential

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE – OVERALL Native-like HIV envelope glycoproteins targeting B cells with the appropriate germline B cell receptor represent the most promising vaccine strategy so far but has only proven to be successful in a subset of vaccinees. Our Program will identify early determinants of broadly neutralizing antibody (bNAb) precursor induction, with a focus on the role of adjuvants and host microbiota, utilizing broad and integrated omics approaches to decipher the mechanisms associated with bNAb development. The results will inform future vaccine design and down- selection.

PI_NAMEs: DE PARIS, KRISTINA  (contact);PERMAR, SALLIE R.

PROGRAM_OFFICER_NAME: PALIN, AMY COLLEEN

PROJECT_TERMS: Adjuvant;Adult;age group;Animals;Antibodies;Antibody-Producing Cells;Automobile Driving;B cell differentiation;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding Sites;Bioinformatics;biological systems;Biometry;Cell Lineage;Cell secretion;Cells;Complex;Computer Analysis;Computer Models;computerized tools;Cross Reactions;Data;design;Development;Dose;Early identification;Emulsions;Epitopes;Event;Frequencies;Future;gene regulatory network;Germ Lines;Glycoproteins;Goals;HIV;HIV envelope protein;HIV Infections;HIV vaccine;host microbiota;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunization;Immunize;Immunoglobulin Somatic Hypermutation;Immunology;Individual;Infant;Infection;Innate Immune Response;Knowledge;Life;Macaca mulatta;Mature B-Lymphocyte;Metagenomics;microbiome;microbiome signature;microbiota;Minority;Modeling;Molecular Profiling;Natural Immunity;neutralizing antibody;nonhuman primate;Pathway interactions;Plasma;programs;response;Role;sexual debut;Shapes;Statistical Data Interpretation;Systems Biology;Testing;TLR7 gene;transcriptomics;Vaccinated;Vaccination;vaccine candidate;Vaccine Design;vaccine evaluation;vaccine strategy;vaccine trial;Vaccinee;Vaccines

PROJECT_TITLE: Determinants of HIV broadly-neutralizing antibody precursor induction in infants


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DE PARIS, KRISTINA  (contact)

PROJECT_TERMS: Accounting;Administrative Personnel;Agreement;Automobile Driving;B-Lymphocytes;Biometry;Collaborations;Communication;Communities;Computer Analysis;Country;Data;data management;Data Reporting;data sharing;Databases;Decision Making;Dedications;Doctor of Philosophy;Documentation;Early identification;Ensure;Fostering;Funding;Goals;Grant;Guidelines;HIV;HIV vaccine;Human Resources;Individual;Infant;Infrastructure;Institution;International;knowledge integration;Leadership;Macaca mulatta;meetings;Monitor;multidisciplinary;neutralizing antibody;nonhuman primate;Occupational activity of managing finances;operation;Output;Paris, France;Physicians;Policies;Principal Investigator;Productivity;programs;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Schedule;Scientist;Secure;Site;Strategic Planning;success;symposium;synergism;United States National Institutes of Health;Universities;Vaccination;Vaccine Design

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Microbiome;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: 1 year old;Address;Adherence;Adjuvant;Adolescent;Adult;Animals;Antibodies;Authorization documentation;B cell differentiation;B-Lymphocytes;Binding Sites;Biological Assay;Biological Factors;Biological Products;Breeding;California;Cell Lineage;Child;Childhood;Clinical;Clinical Data;Collaborations;Communicable Diseases;Communication;Databases;Decision Making;Dedications;Development;Electronic Mail;Emulsions;Ensure;Epidemic;experience;experimental study;Foundations;genetic signature;Germ Lines;Goals;gut microbiome;Health;HIV;HIV envelope protein;HIV vaccine;HIV/AIDS;Housing;Human;human disease;human model;IACUC;Immune;Immune system;Immunity;Immunization;Immunize;Infant;Infection;Infrastructure;Knowledge;Lead;Macaca;Macaca mulatta;Maintenance;meetings;microbiome;Mission;Modeling;Molecular;Monitor;Nature;neutralizing antibody;nonhuman primate;Observational Study;Paris, France;Partner in relationship;pathogen;Pathway interactions;Pregnancy;Primates;procedure safety;Procedures;Productivity;programs;Progress Reports;Regimen;Regulation;Research;Research Project Grants;Resources;Role;sample collection;Sampling;Services;symposium;Systems Biology;Time;Translational Research;Update;vaccine delivery;vaccine strategy;Vaccinee;Vaccines

PROJECT_TITLE: Core B: Non-human Primate Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: NARRATIVE The goal of this study is to determine the role that socio-environmental contextual factors, including neighborhood socioeconomic status (SES) and the built environment, play in racial disparities in monoclonal gammopathy of undetermined significance (MGUS), the precursor to multiple myeloma. By measuring and thus disentangling the SES associations for MGUS by built environment attributes, we believe that potential new environmental influences may be illuminated as key factors for the racial disparities observed in incidence and prevalence of these diseases.

PI_NAMEs: BERTRAND, KIMBERLY A. (contact);WANG, SOPHIA S.

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;Adolescence;Adult;Affect;African American;African American population;Archives;Behavior;Biological Assay;biological specimen archives;black women;Blood;Blood specimen;built environment;burden of illness;California;Categories;Censuses;Characteristics;Childhood;Chronic;Classification;Climate;cohort;Collection;contextual factors;Country;Crowding;Data;Data Pooling;deprivation;Development;Diabetes Mellitus;Diagnosis;Disease;Disparity;Early Diagnosis;economic disparity;Education;Educational Status;Environment;Environmental Pollution;Epidemiology;epidemiology study;Etiology;Evaluation;experience;fast food;Foundations;Genetic;Geography;Goals;Health;high risk;improved outcome;Incidence;Incidental Findings;Income;indexing;Individual;Infection;innovation;insight;interest;Intervention;Joints;Knowledge;Laboratories;Life;lifestyle factors;Link;low socioeconomic status;Malignant Neoplasms;man;Measures;Mediation;Methods;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;neighborhood association;neighborhood disadvantage;Neighborhoods;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;Physical activity;Plasma Cells;Play;Population;population health;Population Heterogeneity;Population Study;predictive modeling;Prevalence;Prevention Measures;Psychosocial Stress;Questionnaires;Race;racial difference;racial disparity;Research;Research Design;Research Support;Resources;Risk;Risk Factors;Risk Reduction;Role;Rural;screening;social determinants;Social Environment;social factors;socioeconomic diversity;Socioeconomic Status;socioeconomics;study population;teacher;Time;Underrepresented Populations;Urbanicity;walkability;White Women;Women's cohort;Women's Health

PROJECT_TITLE: Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: ! ! Project Narrative Lifecourse social and environmental circumstances may influence variation in risk for Alzheimer’s disease and related dementias (ADRDs), including for US Latinos who face a disproportionate burden of both social adversity and exposure to pesticides via agricultural work. Yet, little is known about the unique and combined impacts of social adversity and pesticide exposure on ADRDs risk and risk factors, including for Latinos. In this project, we will leverage an ongoing cohort of Latina women living in an agricultural region and entering mid-life to study the relationship between early and mid-life social adversity, pesticide exposure, and ADRDs risk factors, measured via repeated cognitive assessments, brain biomarkers, and cardiovascular and inflammatory markers. !

PI_NAMEs: TORRES, JACQUELINE MARIE (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Aging;agricultural community;agricultural pesticide;agricultural region;Agriculture;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Biological Markers;Birth;Brain;brain magnetic resonance imaging;California;cardiometabolic risk;cardiometabolism;Cardiovascular system;Child;Chronic;Cognitive;cognitive ability;Cognitive aging;cognitive performance;cognitive testing;cohort;Data;Data Collection;data harmonization;dementia risk;Diabetes Mellitus;Disadvantaged;Disease;early onset;Early Onset Alzheimer Disease;Enrollment;Environmental Exposure;Environmental Risk Factor;experience;Exposure to;Face;Family;Farm;farm worker;follow-up;Geographic Information Systems;Goals;Health;health assessment;Heterogeneity;High Prevalence;Home;Household;human old age (65+);Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Intervention;late life;Latina;Latina Population;Latino;Latino Population;Life Cycle Stages;Link;Literature;Low income;Magnetic Resonance Imaging;Measures;Mediating;member;Mexican Americans;middle age;migration;Minority Groups;Mothers;National Institute of Environmental Health Sciences;Obesity;Occupations;operation;Outcome;Participant;Pathology;Pattern;pesticide exposure;Pesticides;Population;Poverty;Prevention;prospective;Recording of previous events;Reporting;Research;Risk Factors;Sampling;Shapes;social;social adversity;social factors;Spanish;Stress;Stressful Event;Structure;Variant;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(56)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adult;Antibodies;Antibody Avidity;Antibody Repertoire;Antibody Response;Antigens;Autologous;autoreactivity;Avidity;B-Cell Antigen Receptor;B-Cell Development;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Binding;Biological Assay;Biometry;Bone Marrow;Cell Lineage;Cells;Collaborations;Computer Analysis;Data;Development;Dose;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Epitopes;Evolution;experience;Flow Cytometry;Future;Generations;genetic signature;genomic platform;Germ Lines;Goals;HIV;HIV vaccine;HIV-1;Immune;Immune response;Immune system;Immunity;Immunization;Infant;Infection;innovation;Laboratories;Lead;Life;lymph nodes;Lymphoid Tissue;Macaca;Macaca mulatta;Mediating;Medicine;Messenger RNA;microbial;microbiome;microorganism interaction;Molecular Profiling;Monoclonal Antibodies;Natural Immunity;Nature;neutralizing antibody;next generation sequencing;nonhuman primate;Phenotype;Plasma;Plasma Cells;Predisposition;Process;programs;Proteomics;Regimen;Reproducibility;Resources;response;Running;Serum;single-cell RNA sequencing;Sorting;Specificity;Surface Plasmon Resonance;Technology;Time;time use;tool;transcriptomics;transmission process;Vaccinated;Vaccination;Vaccine Design;vaccine evaluation;vaccine immunogenicity;vaccine strategy;Vaccinee;Vaccines;Virus;Work

PROJECT_TITLE: Core C: B Cell Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE/ RELEVANCE Plague, caused by Yersinia pestis, is endemic in the Western US with potential to re-emerge as a deadly flea- borne zoonotic disease that can be transmitted from person-to-person. Although hundreds of years of research have led to a strong understanding of transmission and pathogenesis, there remains a lack of knowledge of the enzootic maintenance of Y. pestis and the factors that support an epizootic outbreak. This project addresses this gap by applying modern technologies to examine Y. pestis escape from the midgut and the potential for transovarial transmission to propagate infection in the flea vector thereby contributing to the enzootic maintenance of plague.

PI_NAMEs: ANDERSON, DEBORAH M (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Address;Adherence;Adult;Adverse effects;Anatomy;Animals;Area;Bacteria;Biological Assay;Blood;Bubonic Plague;Contracts;Data;Development;Disease;Disease Outbreaks;Ecology;Ecosystem;egg;Electron Microscopy;Engineering;Environment;enzootic;Epithelial Cells;Epithelium;epizootic;Event;Evolution;experience;experimental study;Face;feeding;Ferrets;flea-borne;Fleas;follow-up;foot;Foundations;Gastrointestinal tract structure;Generations;Geographic Locations;Goals;Grasslands;Growth;high reward;high risk;Human;human disease;human mortality;Image;Immunity;Infection;innovation;Knowledge;Laboratories;Larva;Life;Life Cycle Stages;Maintenance;Mammals;mathematical model;Mediating;Microbial Biofilms;Microscopic;Midgut;Modernization;Montana;mortality;mouse model;next generation;North America;Outcome;pandemic disease;Pathogenesis;Persons;Plague;Play;Population;Prairie Dog;Precipitation;Production;Proteins;Proventriculus;Public Health;Pupa;Rattus;Reporter;reproductive organ;Research;Resolution;Risk;Rodent;Role;Rural Population;Scanning Electron Microscopy;surveillance data;Technology;Temperature;Three-Dimensional Image;Tissues;Transmission Electron Microscopy;transmission process;United States;vector;Virulent;Visualization;Wild Animals;Work;Yersinia pestis;Zoonoses

PROJECT_TITLE: Transovarial transmission of yersinia pestis in fleas

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Microbiome;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ZOU, FEI  (contact)

PROJECT_TERMS: Address;Adjuvant;Affinity;analytical tool;Archives;B-Lymphocytes;Bioinformatics;Biological;Biological Response Modifiers;Biometry;Biostatistical Methods;Biostatistics Core;Communities;Computer Analysis;computerized tools;Data;Data Analyses;data integration;data management;Data Science;Data Science Core;design;Development;differential expression;dimension reduction;Early identification;Ensure;Experimental Designs;FAIR principles;Generations;Genes;Germ Lines;Goals;high dimensionality;HIV;HIV envelope protein;HIV vaccine;host microbiota;Human Resources;Immune;immunoregulation;Infant;innovation;insight;interoperability;Knowledge;Lead;longitudinal analysis;Mediation;Mediator;Metabolic Pathway;Methodology;Methods;microbial signature;microbiome;microbiome analysis;microbiome signature;Modality;Modeling;Molecular;Molecular Profiling;multidimensional data;multimodality;Multiomic Data;multiple omics;neutralizing antibody;novel;Output;Pathway Analysis;Pathway interactions;Plasma;programs;Proteome;quality assurance;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;response;Role;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;statistics;Sum;Time;tool;transcriptomics;Vaccination;Vaccine Adjuvant;Vaccine Design;vaccine response;vaccine strategy;Vaccinee;verification and validation;Work

PROJECT_TITLE: Core D: Biostatistics and Computational Analysis Core


ADMINISTERING_IC: NS

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Astrocytes are among the most abundant cells in the human brain, they are in close contact with nearly all synapses, and have emerged as important regulators of nearly every aspect of brain development, function and maintenance. Compelling evidence now exists that astrocytes participate in the processing of information in neural circuits and ultimately control behavioral output, but how they do this remains poorly defined. Our work will shed light on how astrocytes receive information from neurons and in turn modulate neural circuit activity, basic operational principles of the brain that are highly relevant to human brain function and disease.

PI_NAMEs: FREEMAN, MARC R (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acetylcholine;Adenylate Cyclase;Adrenergic Receptor;Affect;Animal Behavior;Arousal;Astrocytes;Bathing;Behavior;Behavior Control;Behavioral;Biology;Brain;Calcium Signaling;Cells;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;designer receptors exclusively activated by designer drugs;Development;Disease;Dopamine;dopaminergic neuron;Drosophila genus;Event;Exhibits;Exposure to;extracellular;fly;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;gene function;Genes;Genetic Screening;Glutamates;Goals;Human;In Vitro;in vivo;information processing;Ions;knock-down;Link;Maintenance;Mediating;Memory;Modeling;Molecular;Molecular Genetics;Morphology;neural;neural circuit;Neurons;neurophysiology;neuroregulation;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;Norepinephrine;Octopamine;optogenetics;Orthologous Gene;Output;Pathway interactions;pharmacologic;Physiology;Preparation;Process;Property;Recycling;response;Role;Seizures;Signal Pathway;Signal Transduction;Signaling Molecule;Sleep;Smell Perception;Source;Stimulus;Synapses;System;tool;TRP channel;Tyramine;tyramine receptor;Visualization;water channel;Work

PROJECT_TITLE: Astrocyte control of neural circuits and behavior

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Nanotechnology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: DALLAS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: A pH Responsive Transistor-like Nanoprobe for Sensitive Detection of Unknown Primary  Cancers of the Head and Neck Project Narrative This application uses activatable fluorescence nanoprobe ONM-100 to evaluate the sensitivity and specificity of detecting unknown primary cancer in head and neck cancer patients after intravenous injection and imaging during surgery.

PI_NAMEs: SUMER, BARAN D (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acidosis;Address;Adjuvant Therapy;Aerodigestive Tract;amphiphilicity;aqueous;Avidity;Basement membrane;Biopsy;Blood Vessels;Cancer Detection;cancer diagnosis;Cancer Patient;Caring;Cells;Chemotherapy and/or radiation;Clinical;Darkness;Data;Detection;detection sensitivity;Endoscopes;Epithelium;Excision;FDA approved;Fluorescence;fluorodeoxyglucose;Freezing;functional improvement;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Histologic;Histology;Histopathology;HPV screening;Human Papillomavirus;human tissue;Image;Impairment;improved;in vivo fluorescence;Indocyanine Green;Inflammatory;Intravenous;intravenous administration;intravenous injection;invention;Libraries;Light;lymph nodes;Lymphatic;lymphocyte proliferation;Lymphoid Tissue;Malignant neoplasm of pharynx;Malignant Neoplasms;Mediating;meter;Micelles;millimeter;Modality;Mucous Membrane;nanoprobe;Nature;Neoplasm Metastasis;Operative Surgical Procedures;optimal treatments;Outcome;overtreatment;Pathology;Patient-Focused Outcomes;Patients;Pharyngeal structure;Phase;Phase II Clinical Trials;Phase Transition;Physical Examination;Polymers;Positron-Emission Tomography;Primary Neoplasm;Prognosis;Quality-Adjusted Life Years;Sensitivity and Specificity;Serious Adverse Event;Staging;Stains;standard of care;Surface;Tail;targeted treatment;Testing;Time;Tissues;Tonsil;Tonsillar Tissue;Tonsillectomy;Transistors;tumor;tumor microenvironment;Validation;Veins;viral detection;X-Ray Computed Tomography

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adjuvant;Adult;Affinity;age related;Agonist;aluminum sulfate;Animals;Antibodies;Antibody Response;Antigen-Presenting Cells;Autologous;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Binding Sites;Biological Response Modifiers;Cell Lineage;Cell Separation;cell type;Cells;Childhood;Coculture Techniques;Collaborations;commensal bacteria;Complex;Computer Models;cytokine;Cytometry;Data;Data Analyses;Dendritic cell activation;Dendritic Cells;Development;Emulsions;Frequencies;Future;Germ Lines;Glycoproteins;Goals;Heart;HIV;HIV Antibodies;HIV envelope protein;HIV vaccine;Human;Immune;immune activation;Immunization;Immunoglobulin Somatic Hypermutation;immunoregulation;improved;Infant;Innate Immune Response;Knock-in Mouse;Leadership;Licensing;lymph nodes;Macaca mulatta;Mediating;Memory B-Lymphocyte;microbiome;microbiota;Molecular Profiling;monocyte;mouse model;Mus;nanoparticle;neutralizing antibody;Newborn Infant;Pathway interactions;Pattern recognition receptor;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Plasma;Plasma Cells;Population;power analysis;Process;programs;Property;Proteome;reconstitution;Regimen;Regulation;Reporting;Research Design;Research Project Grants;response;Saponins;Signal Pathway;single-cell RNA sequencing;Specificity;Structure of germinal center of lymph node;T-Lymphocyte;Testing;TLR3 gene;TLR4 gene;TLR7 gene;Toll-like receptors;transcriptome sequencing;transcriptomics;Vaccinated;Vaccination;Vaccine Adjuvant;Vaccine Design;vaccine development;vaccine evaluation;vaccine strategy;vaccine trial;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: Project 1: The impact of innate immune responses on the development of broadly neutralizing antibodies by vaccination


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pulmonary Arterial Hypertension (PAH) is a lethal lung condition characterized by increased pulmonary artery pressures due to abnormal proliferation of endothelial cells in the blood vessels in the lung. Mitochondrial function and calcium levels are known to abnormal in PAH endothelial cells, but the link between dysfunctional mitochondria and calcium levels is not known. We hope to identify why mitochondria are dysfunctional in PAH endothelial cells, and how such dysfunction promotes abnormal calcium levels, with the hopes to discovering new therapeutic options for this deadly disease.

PI_NAMEs: SURESH, KARTHIK  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: beta-Hydroxybutyrate;Biological Models;Biophysics;Blood Vessels;Calcium;Calcium Signaling;Cell Physiology;Cell Separation;Cessation of life;Data;Development;Disease;Distal;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;experimental study;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Functional disorder;Generations;Genes;Glucose;Glycolysis;Homeostasis;Human;Hypoxia;In Vitro;in vivo;insight;Interruption;Knock-out;Link;live cell imaging;Lung;lung microvascular endothelial cells;Mesenchymal;Metabolic;Metabolic Activation;Metabolic dysfunction;Metabolism;Methods;Microvascular Proliferation;migration;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Molecular Target;Mus;new therapeutic target;novel;novel therapeutics;overexpression;Oxidative Phosphorylation;Pathogenicity;Pathway interactions;Patients;Phenotype;Play;Pre-Clinical Model;pressure;Production;Proliferating;promoter;pulmonary arterial hypertension;pulmonary arterial pressure;pulmonary artery endothelial cell;Rat Transgene;Rattus;Reactive Oxygen Species;receptor;Regulation;Reporter;Reporting;Respiration;right ventricular failure;Rodent Model;Role;Sampling;Serum;Signal Transduction;Smooth Muscle;Supplementation;targeted treatment;Testing;Transgenic Mice;Vanilloid;Vascular Endothelial Cell;Vascular remodeling;Vasodilation;Work

PROJECT_TITLE: Metabolic regulation of Ca2+ entry and endothelial-mesenchymal transition in pulmonary arterial hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Liver Cancer;Liver Disease;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: There are many childhood cancers that have failed to respond to the latest advances in cancer therapeutics. Rather than target the protein that drives the cancer, we will eliminate the RNA that encodes for the protein that drives one of these, the usually lethal liver cancer, Fibrolamellar hepatocellular carcinoma (FLC). Our underlying hypothesis is that we can design ways of eliminating the RNA for the driver that are more specific with fewer side effects and thus produce a more powerful therapeutic than if we had targeted the protein.

PI_NAMEs: SIMON, SANFORD M (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: adeno-associated virus 3 delivery;Adolescent and Young Adult;Affect;Alanine Transaminase;Antisense Oligonucleotides;Attention;Automobile Driving;Base Sequence;Biological Assay;Blood;capsule;Catalytic Domain;Cell Survival;Cells;Chimera organism;Chimeric Proteins;Chromosome 19;Code;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;design;Disease;Dissociation;efficacy evaluation;efficacy testing;End Point Assay;Exons;experimental study;Family;Fibrolamellar Hepatocellular Carcinoma;Fusion Oncogene Proteins;Genetic;Genetic Transcription;Goals;Growth;Health;heat-shock proteins 40;Hepatoblastoma;Hepatocyte;Hepatotoxicity;histopathological examination;Histopathology;Human;Implant;In Vitro;in vivo;Kinetics;knock-down;Liver;Luciferases;luminescence;Malignant Childhood Neoplasm;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;member;Mus;Neoplasm Metastasis;neoplastic cell;Oncogenic;Operative Surgical Procedures;Organoids;patient derived xenograft model;Patients;Phenotype;Phosphotransferases;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Proteins;Recurrence;Research Proposals;RNA;Sampling;Series;short hairpin RNA delivery;side effect;small hairpin RNA;Stage at Diagnosis;Structure;subcutaneous;Tail;Technology;Testing;Therapeutic;Tissues;Transcript;Tropism;tumor;Tumor Burden;tumor growth;tumor xenograft;Veins;Virus;Work

PROJECT_TITLE: ASO and shRNA for targeting the oncogenic transcript driving fibrolamellar hepatocellular carcinoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE To be successful, an antibody-based HIV vaccine must reliably elicit at least 2-3 different specificities of potent, broadly neutralizing HIV antibodies. We have assembled a stellar team of investigators into the Multi-Omics Vaccine Evaluation (MOVE) Consortium to propose a streamlined approach for HIV vaccine development, enabled by deeply integrating advanced multi-omics techniques and sophisticated informatics throughout our experimental approach. The overall goal of this proposal is to accelerate development of an HIV vaccine by parallelizing the design and evaluation of promising immunogen candidates and rapidly discover an HIV vaccine that induces broad, durable immunity.

PI_NAMEs: BRINEY, BRYAN  (contact)

PROGRAM_OFFICER_NAME: MACIEL, MILTON

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Animal Model;Antibodies;Antibody Response;Antibody Specificity;Antigens;Apical;B cell repertoire;B-Lymphocytes;Cells;Collaborations;computerized tools;design;Development;Epitopes;Evaluation;Frequencies;Genetic;Goals;HIV;HIV Antibodies;HIV vaccine;Human;human monoclonal antibodies;humanized mouse;Immune response;Immunity;Immunization;immunogenicity;improved;Individual;Informatics;innovation;Mission;multidisciplinary;multiple omics;neutralizing antibody;novel;pandemic disease;parallelization;Pattern;Polysaccharides;Productivity;Proliferating;Proteomics;Protocols documentation;Recording of previous events;Research Personnel;Resolution;Series;Serum;Site;Specificity;Speed;Techniques;Technology;Testing;Tissues;tool;vaccine development;vaccine evaluation;Vaccines;Vertebral column;Viral

PROJECT_TITLE: The Multi-omics Vaccine Evaluation (MOVE) Consortium


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Administrative Efficiency;Budgets;Collaborations;Communication;Coordination and Collaboration;cost effective;data dissemination;data exchange;data sharing;data sharing networks;Decision Making;design;Ensure;Evaluation;flexibility;Funding;Goals;Information Technology;Infrastructure;Institution;Intellectual Property;interest;Leadership;life span;Manuscripts;Mediating;meetings;member;Monitor;multiple omics;open source;operation;Outcome;Preparation;Program Evaluation;programs;Progress Reports;Publications;Research Personnel;Research Project Grants;Resolution;Resource Allocation;Resources;response;Schedule;Specimen;Structure;success;supportive environment;symposium;Technology Transfer;Teleconferences;timeline;Training;Travel;vaccine evaluation;Work

PROJECT_TITLE: Admin Core


PROJECT_TERMS: Adjuvant;Adult;Animals;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Bacteria;Binding Sites;Bioinformatics;Cell Lineage;Clinical Trials;Clone Cells;commensal bacteria;commensal microbes;Computer Analysis;Cross Reactions;cross reactivity;Data;Data Analyses;design;Development;Disparate;early phase clinical trial;Ensure;Environment;Epitopes;Evolution;fecal microbiome;Frequencies;Future;Generations;Genes;Germ Lines;Gnotobiotic;Goals;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;host microbiome;Human;Immune;Immune response;Immune system;Immunization;Immunoglobulin G;Immunophenotyping;immunoregulation;Individual;Infant;Infection;interest;Intervention;Knock-in Mouse;Life;Mediating;Metagenomics;Microbe;microbial;microbial signature;microbiome;microbiome components;microbiota;microorganism;mouse model;neutralizing antibody;nonhuman primate;novel;novel strategies;Outcome;Pathway interactions;Phenotype;Play;Process;programs;rational design;Research;response;Role;Shotguns;simian human immunodeficiency virus;synergism;Testing;translational potential;Translations;Vaccinated;Vaccination;vaccination strategy;Vaccine Design;vaccine response;vaccine strategy;vaccine-induced antibodies;Vaccinee;Vaccines;Viremia;Virus Diseases;Work;young adult

PROJECT_TITLE: Project 2: Microbial determinants of HIV broadly-neutralizing antibody precursor induction in infants


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;HIV/AIDS;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: HUGHES, LAURA D. (contact)

PROJECT_TERMS: Acceleration;Adoption;analysis pipeline;Animal Model;Antibodies;Antibody Response;Antigens;Bioinformatics;Collaborations;Communities;community engagement;Computer software;Connective Tissue;Custom;Data;Data Collection;data dissemination;data ingestion;data management;data pipeline;data portal;data reuse;Data Set;data sharing;data standards;data streams;design;Development;Disparate;Ensure;Evaluation;FAIR principles;Generations;Goals;heterogenous data;HIV;HIV vaccine;Human;Immune response;Immunity;immunogenicity;Immunologics;improved;innovation;Internet;interoperability;Metadata;Mission;Monitor;multidimensional data;multidisciplinary;Multiomic Data;multiple omics;open data;Phylogenetic Analysis;Proliferating;Proteomics;Protocols documentation;Publishing;reconstruction;repository;Reproducibility;Research;response;Sampling;Software Tools;Speed;Techniques;Technology;Testing;Time;tool;Vaccine Design;vaccine evaluation;vaccine-induced antibodies;Vaccines;Visualization;Visualization software;web portal

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Eliciting robust, specific, and durable adaptive immune responses via vaccination constitutes an effective and safe countermeasure against COVID-19 disease. The proposed research is relevant to public health because it will provide critical insights to optimize future COVID-19 vaccination strategies in children. The proposed work is relevant to the NIH mission to acquire fundamental knowledge that will help reduce morbidity and mortality that stems from COVID-19 disease.

PI_NAMEs: HSIEH, WEN-YUAN E (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 11 year old;16 year old;2019-nCoV;4 year old;5 year old;Acute;adaptive immune response;Address;Adolescence;Adult;Affect;Affinity;Agammaglobulinemia;Age;age effect;age group;age related;Antibodies;Antigens;B cell differentiation;B cell therapy;B-Lymphocytes;Basic Science;biobank;Blood;Blood specimen;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Childhood;Clinic;Clinical Data;Clinical Sciences;cohort;Colorado;COVID-19;COVID-19 disparity;COVID-19 incidence;COVID-19 vaccination;COVID-19 vaccine;cytokine;Cytometry;Data;Defect;Disease;early childhood;Exhibits;follow-up;Future;Genetic;Goals;Growth;Hospitalization;hospitalization rates;humoral immunity deficiency;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;Immunoglobulin A;Immunoglobulin G;Immunologic Memory;Immunologics;Immunologist;In Vitro;Infection;Infrastructure;insight;Interferons;Intramuscular;Knowledge;Lead;Learning;Life;Longitudinal cohort;Maintenance;Mission;Molecular;Morbidity - disease rate;mortality;Mucosal Immunity;Mucous Membrane;multiple omics;Multiple Sclerosis;multiple sclerosis patient;Myelogenous;nasopharyngeal swab;Participant;Pathologic;Pathology;Pediatric cohort;Pediatric Hospitals;Persons;Pfizer-BioNTech COVID-19 vaccine;Phenotype;Physicians;Physiological;Population;Production;prospective;Public Health;receptor binding;Research;Resources;response;RNA vaccination;RNA vaccine;Role;Saliva;Sampling;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Scientist;Serum;Severities;stem;Structure;Surface;T cell differentiation;T cell response;Testing;transcriptome sequencing;transcriptomics;Translating;transmission process;United States National Institutes of Health;Vaccinated;Vaccination;vaccination strategy;Vaccine Clinical Trial;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine response;vaccine trial;Vaccines;Variant;Virus;Work

PROJECT_TITLE: SARS-CoV-2 Vaccine Responses in children with genetic or acquired B cell deficiencies

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: WARD, ANDREW BARRETT (contact)

PROJECT_TERMS: Affinity;animal data;Animal Model;Animals;Antibodies;Antibody Binding Sites;Antibody Response;Antigens;Apical;B cell repertoire;B-cell receptor repertoire sequencing;B-Lymphocytes;Cells;Clinical Research;Complementarity Determining Regions;Cryoelectron Microscopy;Data;data format;database query;design;Development;Electron Microscopy;Epitopes;Genes;Germ Lines;HIV;HIV Antibodies;HIV vaccine;Human;Immune response;Immune Sera;Immunize;Immunoglobulin Somatic Hypermutation;Individual;iterative design;Knock-in;Knock-in Mouse;Maps;Methods;Molecular;Monoclonal Antibodies;mouse model;multiple omics;Mus;Negative Staining;neutralizing antibody;nonhuman primate;pathogen;phase I trial;polyclonal antibody;Polysaccharides;pre-clinical;Proteomics;Resolution;single-cell RNA sequencing;Specificity;Structure;Subunit Vaccines;Techniques;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Scientific Core: Structural Proteomics


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Suicide is an important and growing public health problem among young people in the United States with consistently higher rates of suicidal behavior found among youth involved with the juvenile justice system. Little is known about factors associated with suicidal behavior unique to youth incarcerated in the justice system and even less attention has been given to the heightened risk for suicide in youth after they are released. To better inform targeted suicide prevention strategies, the proposed research will use advanced machine learning techniques to examine youth characteristics and conditions of the incarceration environment to identify youth at elevated risk for future suicidal behavior following their release from confinement in the juvenile justice system.

PI_NAMEs: RUCH, DONNA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adolescent;advanced analytics;aged;Applications Grants;Attention;Back;career;Cause of Death;Characteristics;Clinical Trials;Communities;Complex;contextual factors;court;data integration;effectiveness evaluation;Environment;Environmental Risk Factor;Epidemiology;evidence base;Face;Funding;Future;Goals;health care service;Health Services;Healthcare;high risk;implementation barriers;implementation framework;Implementation readiness;implementation science;Imprisonment;improved;Individual;innovation;innovative technologies;insight;Intake;Intervention;Justice;juvenile justice system;Knowledge;Link;Longitudinal cohort study;Machine Learning;machine learning model;Mental Health;Mental Health Services;Modeling;National Institute of Mental Health;novel;Persons;Policies;Population;Prevention;Prevention Research;Prevention strategy;preventive intervention;Procedures;Process;Public Health;Qualitative Research;Recommendation;reducing suicide;Research;Research Methodology;Research Priority;Resources;Risk;risk prediction;risk prediction model;segregation;Services;skill acquisition;skills;Structure;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;System;Techniques;Time;Training;Training Support;Translating;Underserved Population;United States;Victimization;Violence;Vulnerable Populations;Youth

PROJECT_TITLE: Epidemiologic and Machine Learning Approaches to Frame Suicide Prevention Strategies Among Juvenile Justice Youth - 2021

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Modified Public Health Relevance Section  Modest weight loss (>5% body weight) is the most effective strategy to help individuals with prediabetes prevent or delay type 2 diabetes mellitus. Most individuals with prediabetes, however, do not engage in evidence-based Diabetes Prevention Programs for weight loss, and healthcare systems currently lack effective, coordinated, and patient-centered strategies to successfully support patients’ weight loss with other evidence-based resources (e.g. behavioral change programs, pharmacotherapy). This proposal aims to develop and test an innovative, multilevel primary care-based intervention to support weight loss among adults with prediabetes through (1) personalized weight loss plans; (2) remote weight monitoring using home-based digital scales; and (3) proactive outreach to address barriers and/or adapt plans if target weight loss is not achieved.

PI_NAMEs: GRIAUZDE, DINA HAFEZ (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adherence;Adult;Award;Behavior;Behavioral;Body Weight;Body Weight Changes;Body Weight decreased;career;career development;Caring;Chronic;Chronic Disease;Clinic;Clinical;Clinical effectiveness;clinical encounter;clinical implementation;clinical practice;clinically significant;Cohort Analysis;Communities;Counseling;Data;design;Development;Development Plans;Diabetes prevention;diabetes prevention program;Diet;digital;Effectiveness of Interventions;effectiveness/implementation hybrid;Electronic Health Record;Enhancement Technology;Environment;Evaluation;evidence base;experience;Face;follow-up;Foundations;Future;Goals;Guidelines;Health Services;Health system;Healthcare Systems;Home;hybrid type 1 design;implementation science;implementation strategy;improved;Individual;informant;innovation;Internist;Intervention;intervention refinement;Interview;Kilogram;Knowledge;Leadership;Life Style;Link;Measures;meetings;member;Mentors;Methods;Monitor;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;obesity management;Outcome;outreach;Patient Monitoring;patient oriented;Patient-Centered Care;Patients;Pharmacotherapy;Physical activity;Physicians;pilot test;Play;practice setting;pragmatic trial;Prediabetes syndrome;preference;prevent;Prevention;Prevention strategy;Primary Care;primary care practice;primary care provider;primary care setting;primary care team;primary outcome;programs;Provider;provider behavior;public health relevance;Research;research and development;research clinical testing;Research Personnel;Resources;Risk;Risk Reduction;Role;Scientist;Site;skills;Structure;System;Testing;theories;therapy design;Time;tool;Training;treatment planning;uptake;Visit;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: A multilevel intervention to support weight loss among individuals with prediabetes in primary care settings

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: BATISTA, FACUNDO DAMIAN (contact)

PROJECT_TERMS: Adjuvant;adoptive B cell transfer;Adoptive Transfer;Animal Experiments;Animal Model;Animals;Antigens;Apical;Area;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Bone Marrow;Cessation of life;Communicable Diseases;CRISPR/Cas technology;design;Development;Epitopes;Evaluation;experimental study;Feedback;Formulation;Frequencies;Generations;Genetic;Germ Lines;HIV;Human;Human immunodeficiency virus test;human monoclonal antibodies;humanized mouse;Immune response;Immunization;Immunoglobulins;improved;Infection;Infrastructure;Institution;Knock-in;Knock-in Mouse;Light;Lymph;lymph nodes;Maintenance;Modeling;monomer;mouse model;multiple omics;Mus;Oocytes;Output;peripheral blood;Phase I Clinical Trials;Plasma;Polysaccharides;pre-clinical;Pre-Clinical Model;Process;Production;Proteins;Protocols documentation;PTPRC gene;Public Health;response;RNA;Role;Sampling;Spleen;Technology;Tissues;Titrations;tool;vaccine development;vaccine evaluation;vaccinology;Validation

PROJECT_TITLE: Scientific Core: Animal Models


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera, which is responsible for severe morbidity and mortality in developing countries around the world. These proposed studies will characterize Vibrio cholerae-gut microbiome interactions in the protective mucus layer of the gut during V. cholerae infection, with the goal of better understanding how V. cholerae using intestinal mucin to promote pathogenesis and interactions with resident microorganisms and the host, and, potentially, discovering novel therapeutic and prophylactic interventions for cholera.

PI_NAMEs: HSIAO, ANSEL ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Adherence;Affect;Area;Automobile Driving;Bangladesh;Carbohydrates;Carbon;Cell model;Cells;Characteristics;Cholera;cohort;Communities;Complex;Developing Countries;Diarrhea;diarrheal disease;Disease;Disease Outcome;disease phenotype;dysbiosis;enteric infection;Enzymes;Epithelial Attachment;Epithelial Cells;Epithelium;Etiology;fecal microbiota;Fibronectins;fitness;Genetic Determinism;Genetic Techniques;Genetic Transcription;Glycoproteins;Gnotobiotic;Goals;Goblet Cells;Growth;gut microbes;gut microbiome;gut microbiota;host-microbe interactions;Human;Human Characteristics;In Vitro;in vivo;Individual;Infection;Intervention;Intestines;Malnutrition;Mediating;member;Metabolic;Metabolism;Metalloproteases;Microbe;microbial community;microbiome;microbiota;microorganism;microorganism interaction;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;Muc 2 protein;Mucin-2 Staining Method;mucinase;Mucins;Mucolytics;Mucous body substance;Mucous Membrane;Mus;mutant;novel therapeutics;Outcome;pathogen;Pathogenesis;Penetration;Play;Population;Population Heterogeneity;Predisposition;Process;Production;Proliferating;prophylactic;Proteins;Recurrence;resident commensals;Resistance;Resistance to infection;Resolution;response;Role;Series;Shapes;Site;Small Intestines;Source;Specificity;Structure;Surface;Testing;tissue culture;Variant;Vibrio cholerae;Vibrio cholerae infection;Virulence;Virulence Factors

PROJECT_TITLE: The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


PI_NAMEs: ANDRABI, RAIEES AHMAD (contact)

PROJECT_TERMS: Address;Affinity;Animal Model;Antibodies;Antibody Affinity;Antibody Response;Antigens;Apical;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biology;Cell Lineage;Consensus;design;Development;Directed Molecular Evolution;Elements;Engineering;Epitopes;Exclusion;Exhibits;Failure;Germ Lines;Grant;HIV;HIV envelope protein;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immunization;Immunoglobulin Gene Rearrangement;Immunoglobulin Somatic Hypermutation;In Vitro;in vivo;Infection;Knock-in Mouse;Laboratories;Macaca mulatta;Memory B-Lymphocyte;Methods;Molecular;Molecular Conformation;mouse model;multiple omics;neutralizing antibody;novel;novel strategies;Peptides;Polishes;Polysaccharides;preclinical trial;prevent;Property;rational design;Regimen;Research Design;response;Scheme;simian human immunodeficiency virus;Site;Structure;Surface;T cell response;Testing;Time;tool;Translating;Vaccination;Vaccine Design;vaccine evaluation;vaccine platform;Vaccine Research;vaccine strategy;vaccine-induced antibodies;Vaccines;Variant;Virus Replication;Work

PROJECT_TITLE: Project 1: Immunogen Design and Delivery


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We seek to train the next generation of social, economic, and health professionals to carry out theoretically informed, methodologically sophisticated interdisciplinary research on demographic and population studies focused on child health and human development. We provide trainees with rigorous cross-disciplinary coursework in theory, methods, and evidence in core disciplines including economics, sociology, and public health. Trainees are mentored intensively to promote their development into independent investigators.

PI_NAMEs: BELTRAN-SANCHEZ, HIRAM ;HEUVELINE, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TITLE: California Center for Population Research Training Program


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cancer;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Skin Cancer

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The primary aim of this proposal is to determine in a prospective observational study whether immune checkpoint inhibitors (ICI’s) are associated with accelerated progression of coronary atherosclerotic plaque by serial measurement of coronary plaque using coronary CTA. In animal and basic studies, these same immune checkpoints are also critical negative regulators of atherosclerosis and blockade of these checkpoints in animal studies increased atherosclerosis. The use of ICI’s has increased and continues to rapidly expand; therefore, there is an urgent need to test in a clinical study whether ICIs lead to accelerated coronary atherosclerosis and to provide insights into the mechanisms involved.

PI_NAMEs: NEILAN, TOMAS G (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acceleration;Adrenal Cortex Hormones;Age;animal data;Animals;Aorta;Arterial Fatty Streak;Atherosclerosis;attenuation;Automobile Driving;Bioinformatics;Biological Factors;Biological Markers;Biology;BRAF gene;Calcium;cancer care;cancer cell;Cancer Patient;Cardiac;Cardiovascular system;CCL2 gene;CD8B1 gene;Cells;Characteristics;Clinical;Clinical Data;Clinical Research;Clinical Trials;Coagulation Process;cohort;Control Groups;Coronary;Coronary Arteriosclerosis;coronary computed tomography angiography;coronary plaque;CTLA4 gene;Data;density;Diabetes Mellitus;Disease;Dose;Eligibility Determination;Endothelium;Enrollment;Event;Fibrin fragment D;Genomics;Glycosylated hemoglobin A;high risk;HIV;Hypertension;Image;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immune function;Immune system;immune-related adverse events;Immunologic Markers;Immunology;indexing;Inflammation;inhibitor;innovation;insight;Insulin;Interleukin-6;Intervention Trial;Lead;Link;Lipids;lipoprotein-associated phospholipase A(2);Malignant Neoplasms;Measurement;Measures;Mediating;Melanoma;Melanoma patient;Modeling;Morphology;Mutate;Mutation;Observational Study;Oncology;oxidized low density lipoprotein;Participant;Particle Size;Pathway interactions;Patients;PD-1 blockade;Persons;programmed cell death ligand 1;programmed cell death protein 1;progression risk;prospective;Prospective Studies;Randomized;recruit;Retrospective Studies;Risk;RNA;Serum;single cell genomics;Specific qualifier value;Subgroup;T cell infiltration;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Thromboplastin;Time;Toxic effect;Troponin;tumor progression;Vascular Cell Adhesion Molecule-1;Work

PROJECT_TITLE: Immune checkpoint inhibitors and accelerated coronary atherosclerosis

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Diabetes mellitus is a major cause of morbidity and mortality in the United States and research by a new generation of investigators is required to more effectively prevent and treat diabetes. This program will provide intensive post-doctoral training in diabetes research for MD and PhD trainees in a highly collaborative, multidisciplinary environment that promotes diversity at the University of Illinois at Chicago, the largest university in the Chicago area.

PI_NAMEs: UNTERMAN, TERRY G. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Research Training;Training Programs

PROJECT_TITLE: UIC Diabetes Research Training Program

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adult;Affinity;Animal Model;Antibodies;Antigens;B-Lymphocytes;Bar Codes;Bioinformatics;Cells;Classification;Clinical Trials;cohort;cross reactivity;data integration;data management;data sharing;design;Development;Ensure;Epitope Mapping;Epitopes;Evaluation;experimental study;Feedback;Genetic;genetic analysis;Goals;HIV;HIV vaccine;Human;humanized mouse;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin Class Switching;improved;informatics tool;Knock-in Mouse;Leukapheresis;Mission;Modernization;Monoclonal Antibodies;mouse model;multiple omics;neutralizing antibody;novel;pandemic disease;parallelization;Pattern;Phenotype;Process;Proteomics;Resolution;Resources;response;Sampling;Series;Specificity;Speed;success;Techniques;Technology;Testing;Time;time interval;time use;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Visualization software

PROJECT_TITLE: Project 2: Immune Response Analysis


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

PHR: Program Director/Principal Investigator (Last, First, Middle): Wu, Xiaohua, TSRI Studying the mechanisms underlying the protection of common fragile sites and structure- prone DNA sequences Project Narrative  DNA sequences prone to forming secondary structures, such as AT-rich sequences present in common fragile sites (CFSs) and G-quadruplexes (G4s), are genetically unstable and are often associated with chromosomal rearrangement breakpoints in cancer. We aim to study the mechanisms underlying the protection of structure-prone DNA sequences in mammalian cells and explore the functional coordination of pathways involved in maintaining the integrity of these sequences. Our study will provide new mechanistic insights into how genome stability is maintained in mammalian cells and offer new therapeutic strategies for targeted cancer treatment.

PI_NAMEs: WU, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Abbreviations;Address;Aphidicolin;Applications Grants;AT Rich Sequence;ATRX gene;cancer therapy;Cells;chemotherapy;chromatin immunoprecipitation;chromatin remodeling;Chromatin Remodeling Factor;Chromosomal Rearrangement;Chromosome Fragile Sites;Chromosome Structures;Chromosomes;Colon Carcinoma;Colonic Neoplasms;Complex;DAXX gene;Deposition;Development;DNA;DNA biosynthesis;DNA replication fork;DNA Sequence;DNA Single Strand Break;Double Strand Break Repair;ERCC1 gene;Exhibits;Foundations;G-Quartets;Gene Conversion;Genome Stability;genome-wide;homologous recombination;Human Genome;hydroxyurea;insight;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Metaphase;Mismatch Repair;Mismatch Repair Deficiency;Mitotic;Mitotic Recombination;Modeling;Molecular;Molecular Chaperones;MSH2 gene;MSH3 gene;Mus;neoplastic cell;novel;novel therapeutic intervention;Pathway interactions;Polyacrylamide Gel Electrophoresis;preservation;prevent;Principal Investigator;programs;Proteins;RAS genes;replication stress;Reporter;Resistance;Role;Structure;synthetic lethal interaction;targeted treatment;telomere;Testing;translocase;treatment strategy;tumor;tumor xenograft;Work

PROJECT_TITLE: Studying the mechanisms underlying the protection of common fragile sites and structure-prone DNA sequences

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Novel therapies for the most common malignant pediatric brain tumor, medulloblastoma, are hindered by a lack of understanding of the roles played by host-derived cells at the local tumor site. This project aims to address this knowledge gap by studying how perturbations in tumor intrinsic kinase signaling alters the composition of the tumor microenvironment (TME) and modulates anti-tumor immunity. Understanding exactly how such pathways can influence the quality of the tumor immune response is a critical step towards garnering prognostic information from the TME cellular characteristics.

PI_NAMEs: ABIFF, MUTA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;anti-tumor immune response;Antitumor Response;Apoptosis;Attenuated;Automobile Driving;cancer infiltrating T cells;CD4 Positive T Lymphocytes;Cell Cycle;Cell Differentiation process;cell type;Cells;Characteristics;Childhood Malignant Brain Tumor;cofactor;Complex;Cyclin-Dependent Kinase 5;cytokine;Data;Development;driver mutation;EphA5 Receptor;Future;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Transcription;Harvest;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune Evasion;immune resistance;Immune response;Immunocompetent;immunogenicity;Immunologic Markers;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo;Inflammation;Inflammatory;Intention;Interferon Type II;Interferons;Intervention;Investigation;IRF1 gene;ITGAM gene;knock-down;Knowledge;Maintenance;Malignant Neoplasms;Mediating;Medulloblastoma;Modeling;mouse model;Mus;Mutation;Myeloid Cells;neoantigens;neoplastic cell;neuropsychiatry;novel;novel therapeutics;Pathway interactions;Phenotype;Phosphotransferases;Play;prognostic;programmed cell death ligand 1;promoter;Proteins;Regulation;Resistance;response;Response Elements;Role;SHH gene;Signal Pathway;Signal Transduction;Site;stem;Subgroup;success;Testing;Transcription Coactivator;Transcriptional Activation;Transducers;tumor;Tumor Cell Line;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Work

PROJECT_TITLE: Role of IRF2BP2 in Tumor Immune Evasion


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sudden Unexpected Death in Epilepsy (SUDEP) accounts for between 8 and 17% of all epilepsy-related deaths and, although our understanding of SUDEP is rudimentary, there is increasing evidence that respiratory arrest after a convulsive seizure is the primary cause in many cases. In support of this, we have found that seizure-induced apnea that occurs during the tonic phase and failure of postictal breathing recovery produce SUDEP in mouse models. Using novel mouse models of SUDEP, we propose to use chemogenetic, optogenetic, and electrophysiological techniques to elucidate the underlying neural circuitry that is recruited to cause seizure-induced apnea and SUDEP.

PI_NAMEs: WENKER, IAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Address;afferent nerve;Apnea;Benchmarking;Brain;Brain Mapping;Brain Stem;Breathing;Bypass;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;Chromosome Mapping;Clonic Seizure;Data;Development;Electrophysiology (science);Elements;Epilepsy;Experimental Designs;Failure;FOXP2 gene;Generations;Genetic;Heart Arrest;hindbrain;In Vitro;in vivo;Individual;Injections;Interruption;Maps;Midbrain structure;Modeling;Motor Seizures;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;National Institute of Neurological Disorders and Stroke;Nerve Fibers;neural;neural circuit;neuronal circuitry;neuronal excitability;Neurons;Nodal;novel;optogenetics;parabrachial nucleus;patch clamp;Patients;Pattern;Phase;Pontine structure;prevent;Prevention strategy;Prosencephalon;receptor;Recovery;recruit;Refractory;Research;respiratory;Respiratory Failure;Risk Factors;Role;SCN8A gene;Seizures;selective expression;Site;Slice;Structure;Sudden Death;sudden unexpected death in epilepsy;Techniques;Testing;Tonic Seizures;Vagus nerve structure;ventilation;Work

PROJECT_TITLE: The neural circuitry of seizure-induced apnea and SUDEP

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Congenital Disorders of Glycosylation (CDGs) are rare diseases of glycosylation pathways with few therapeutic options. CDGs can cause developmental delay, seizures, or early death. This research will better define the mechanisms of these diseases and identify potential therapeutics using disease modelling, genetic perturbation, and a repurposed drug screen.

PI_NAMEs: DALTON, HANS MARTIN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Advisory Committees;Affect;Apoptosis;Biological;Biological Assay;Candidate Disease Gene;career;Cell Culture Techniques;Cell Line;Cell model;Cell Proliferation;Cells;Cellular Metabolic Process;Cessation of life;Clinical Trials;common symptom;Congenital disorders of glycosylation;Defect;Development;Developmental Delay Disorders;developmental disease;Disease;disease model;disease phenotype;Down-Regulation;Drosophila genus;drug repurposing;Drug Screening;drug use screening;endoplasmic reticulum stress;Ensure;Enzymes;Epilepsy;Eye;Faculty;fly;Future;Gene Expression;Genes;Genetic;genetic manipulation;Glycobiology;glycosylation;Goals;Health;Human;Human Cell Line;improved;In Vitro;in vivo;in vivo Model;Inborn Errors of Metabolism;Individual;Institution;Intervention;Learning;Link;loss of function;loss of function mutation;Mass Spectrum Analysis;member;Mentors;Mentorship;Metabolism;metabolomics;Microscopy;Modeling;Molecular;Molecular Biology;Mutation;new therapeutic target;novel therapeutics;Organism;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pre-Clinical Model;Process;Proliferating;protein expression;Proteins;Rare Diseases;reduce symptoms;Research;RNA Interference;Seizures;small molecule;small molecule libraries;Stress;sugar;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Uses;tool;Training;Translating;Universities;Utah;Work;Writing;Yeasts

PROJECT_TITLE: Identifying New Therapeutics and Molecular Mechanisms in Congenital Disorders of Glycosylation.

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Loss of the tumor suppressor SNF5 (SMARCB1) is the established cause of rhabdoid tumors—rare and aggressive childhood cancers with few treatment options and high rates of mortality. This proposal explores the hypothesis that loss of SNF5 drives rhabdoid malignancy, in part, by activating MYC, an oncoprotein with an extensive suite of pro-tumorigenic functions. Completion of this work will expose underlying molecular mechanisms of rhabdoid tumors and reveal whether MYC is a viable target for therapeutic intervention in these cancers.

PI_NAMEs: TANSEY, WILLIAM PATRICK (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acute;Automobile Driving;Binding;Biochemical;Biological Assay;c-myc Genes;Cell Survival;cell transformation;Cells;chemotherapy;Child;Chromatin;Chromatin Remodeling Factor;Complex;Data;Death Rate;Dependence;Diagnosis;Disease;DNA;DNA Binding;Elements;Etiology;Event;experience;Exposure to;Gene Expression Profile;Genes;Genetic;genetic approach;genetic signature;Genetic Transcription;Genome;Genomic approach;Genomics;Goals;inhibitor;innovation;Link;Location;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;Molecular;Mutate;Mutation;Nature;neoplastic cell;Normal Cell;novel;Oncogenic;Oncoproteins;Operative Surgical Procedures;Pathway interactions;Patients;Pattern;pharmacologic;predictive modeling;prevent;Process;Productivity;programs;protein complex;Radiation;rare cancer;recruit;Recurrence;Residual state;Resolution;restraint;Rhabdoid Tumor;Role;Shapes;Site;SMARCB1 gene;SMARCC1 gene;SWI/SNF Family Complex;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;therapeutically effective;transcription factor;Transcription Process;transcriptome;transcriptomics;Treatment Protocols;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Variant;Work

PROJECT_TITLE: The MYC-SWI/SNF connection in rhabdoid tumors

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Osteoporosis;Patient Safety;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative As part of the eMERGE IV (E4) Network clinical trial, we propose to develop 5, and investigate the implementation of 15, “genomic risk assessment” (GRA) scores in a large set of diverse participants. These GRAs will include genetic and non-genetic information. We specifically propose study of implementation and outcomes of GRA scores for colorectal cancer, breast cancer, osteoporosis, coronary artery disease, and glaucoma in the electronic health record.

PI_NAMEs: CROSSLIN, DAVID RUSSELL;JARVIK, GAIL PAIRITZ (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adult;aggregation factor;Alaska Native;Asian ancestry;Caring;Clinical;clinical care;clinical decision support;clinical practice;Clinical Research;Clinical Trials Network;cohort;Collaborations;Colorectal Cancer;Coronary Arteriosclerosis;Data;data curation;Dedications;design;Development;Discipline;Disease;economic outcome;economic value;Economics;Education;Education and Outreach;Effectiveness;Electronic Health Record;Electronics;Enrollment;Environmental Risk Factor;ethical, legal, and social implication;Ethics;Ethnic Population;Evaluation;Family;Family health status;Genetic;Genetic Risk;genetic risk assessment;genome wide association study;genome-wide;genomic data;Genomic medicine;Genomics;Genotype;Glaucoma;Health;Health system;Healthcare;high risk;implementation evaluation;implementation science;improved;Informatics;innovation;Intervention;Leadership;Learning;Machine Learning;Malignant Breast Neoplasm;Measures;Medical;medical specialties;Medicine;Methods;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Native Americans;Natural Language Processing;non-genetic;novel;online resource;Osteoporosis;Outcome;Outcome Measure;Pacific Islander;Participant;Pathogenicity;Patients;Penetrance;Performance;Pharmacogenetics;Phenotype;polygenic risk score;Population;Population Heterogeneity;prevent;Primary Care;Process;Provider;Publishing;Race;Recording of previous events;Risk;Risk Assessment;Risk Factors;Risk Management;risk prediction;screening;Sexual and Gender Minorities;Site;social health determinants;support tools;tool;Underrepresented Populations;Universities;Variant;Washington

PROJECT_TITLE: eMERGE IV Northwest: A partnership to evaluate the use of genomic information in the health care of diverse participants


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical immunomodulatory role in atherosclerotic cardiovascular disease (ASCVD) impacting chronic inflammatory responses. We have identified single nucleotide polymorphisms (SNPs) that substantively alter CD39 ectonucleotidase expression on Tregs and appear to associate with the burden of ASCVD. We will study how these differences in CD39 activity cause aberrant inflammatory responses and determine how these pathways can best be corrected to treat this most important disease.

PI_NAMEs: GUMINA, RICHARD J (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acute;Adenosine;Adoptive Transfer;Agonist;antagonist;Antisense Oligonucleotides;Area;Atherogenic Diet;Atherosclerosis;Biological;Biological Markers;Biological Models;Biology;Biometry;Blood Vessels;Bone Marrow Cells;burden of illness;Cell Compartmentation;Cell Physiology;Cell Separation;cell type;Cells;Chronic;Chronic Disease;Clinical;clinical practice;Clinical Research;cohort;conditional knockout;Coronary Arteriosclerosis;Crohn's disease;Data;Disease;DNA Sequence Alteration;driving force;ecto-nucleotidase;effector T cell;Endothelial Cells;Evolution;Exhibits;Experimental Models;experimental study;extracellular;Failure;FOXP3 gene;Functional disorder;functional genomics;Generations;Genes;Genetic;genetic analysis;Genetic Determinism;Genotype;Goals;healing;Homeostasis;Human;IL2RA gene;Immune;immune checkpoint;immune function;Immune response;Immunity;Immunology;immunoregulation;Inflammation;Inflammatory;Inflammatory Response;insight;knock-down;Knock-out;Link;Lymphoid;Macrophage;Mediating;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;new therapeutic target;novel;novel diagnostics;novel therapeutic intervention;Outcome Study;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;prevent;Process;Production;promoter;Regulation;Regulatory T-Lymphocyte;Research;response;Role;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;SNP genotyping;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Translations;Transplantation;vascular inflammation

PROJECT_TITLE: Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative  Pulmonary infection with Mycobacterium abscessus (pMAB) is particularly challenging to treat because this bacillus displays intrinsic antibiotic resistance to most front-line drugs. Tigecycline, the first tetracycline with a glycyl moiety, overcomes the common resistance mechanisms in rapidly growing mycobacteria but it needs to be administered via intravenous injection. The approach studied here is to develop tigecycline as inhalational therapy for pMAB.

PI_NAMEs: GONZALEZ-JUARRERO, MERCEDES  (contact);MALONEY, SARA ELIZABETH;MEIBOHM, BERND

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Abscess;Acute;Address;Adverse effects;Aerosols;analog;Animal Model;Antibiotic Resistance;Antibiotics;Bacillus;bacterial resistance;bactericide;Biological Availability;Body Fluids;C57BL/6 Mouse;Canis familiaris;Chronic;Clarithromycin;Clinic;Clinical;Clinical effectiveness;Colorado;Complex;cystic fibrosis mouse;cystic fibrosis patients;Deposition;Dose;Drug Exposure;Drug Kinetics;Drug or chemical Tissue Distribution;Dryness;effective therapy;efficacy evaluation;efficacy testing;epithelial Na+ channel;Epithelium;Exhibits;Fiber;flu;follower of religion Jewish;Formulation;Foundations;Frequencies;Future;Genus Mycobacterium;glycylcycline;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hospitals;Hour;human subject;improved;In Vitro;in vitro Assay;in vivo;Infection;Inhalation;Inhalation Drug Administration;Inhalation Therapy;Intravenous;intravenous administration;Intravenous infusion procedures;intravenous injection;Investigational New Drug Application;Knockout Mice;Light;liquid formulation;Liquid substance;Lung;Lung Diseases;Lung infections;Macrolides;Maximum Tolerated Dose;Modeling;Monitor;mouse model;Mus;Mycobacterium abscessus;Nausea and Vomiting;non-tuberculosis mycobacteria;Oral;Oral Administration;Organ;Outcome;particle;Patients;Pharmaceutical Preparations;Pharmacotherapy;Plasma;Powder dose form;pre-clinical;Predisposition;Procedures;Property;Qualifying;Rattus;Recommendation;reconstitution;Regimen;Research;Resistance;resistance mechanism;Route;Safety;side effect;subcutaneous;Symptoms;synergism;System;Tennessee;Testing;Tetracyclines;Therapeutic;Therapeutic Index;tigecycline;Tissues;Toxicology;treatment duration;Treatment Efficacy;Treatment Protocols;Universities;Vertebral column;Withdrawing Treatments

PROJECT_TITLE: Inhaled tigecycline therapy for pulmonary M. abscessus infections

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Much like armor, Gram-negative bacteria (e.g., Escherichia coli) have a unique outer surface that prevents the use of many antibiotics making infections caused by these organisms extremely difficult to treat. This proposal will help determine the molecular machinery used by Gram negatives to assemble their outer surface providing new opportunities for the development of novel therapies to fight multi-drug resistant bacterial infections.

PI_NAMEs: TRENT, MICHAEL STEPHEN (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affinity;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Automobile Driving;Bacteria;Bacterial Infections;Binding Sites;Biochemical;Biogenesis;Biology;cardiolipin synthase;Cardiolipins;cell envelope;Cell Membrane Permeability;Cell Survival;Cells;Cessation of life;Clinical;combinatorial;Cytoplasm;Data;Defect;density;design;Development;Drug Efflux;economic cost;Encapsulated;Enzymes;Equilibrium;Escherichia coli;Face;Feedback;fighting;fitness;Future;Genes;Genetic;global health;Glycerophospholipids;Gram-Negative Bacteria;Growth;Healthcare;Heterogeneity;Infection;insight;Libraries;Lipid A;lipidome;Lipids;lipophilicity;Lipopolysaccharides;Maintenance;Membrane;membrane biogenesis;Membrane Lipids;Modeling;Molecular;Multi-Drug Resistance;mutant;new therapeutic target;novel;novel therapeutics;Organism;pathogen;Pathway interactions;Peptidoglycan;prevent;protein transport;Pump;Regulation;Resistance;Role;Side;stem;Surface;System;Transmembrane Transport

PROJECT_TITLE: The role of cardiolipin in the biogenesis of the Gram-negative bacterial cell envelope

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Hypertension;Prevention

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES RES COLLABORATION

PHR: PROJECT NARRATIVE In Uganda, the prevalence of hypertension among adult persons living with HIV is 27.9% yet only 5% achieve control. Integrating screening and treatment of hypertension in HIV care is recommended by the World Health Organization (WHO) for dual control; however, there is limited implementation of this guideline. The goal of this project is to conduct an implementation science study to integrate hypertension screening and treatment into patient centered community HIV differentiated service delivery models in Uganda using the WHO HEARTS protocol to improve hypertension control in persons living with HIV

PI_NAMEs: MUDDU, MARTIN  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adoption;Adult;Affect;Anti-Hypertensive Agents;Area;Award;Blood Pressure Monitors;Cardiovascular Diseases;career;Caring;Client;Clinic;Clinical;Clinical Medicine;Collaborations;Communities;Community Healthcare;Consolidated Framework for Implementation Research;Control Groups;Data;design;drug distribution;Effectiveness;effectiveness evaluation;End stage renal failure;Environment;evidence base;experimental study;Focus Groups;Funding;Goals;Grant;group intervention;Guidelines;Health Personnel;Health system;High Prevalence;HIV;Hypertension;hypertension control;hypertension treatment;implementation design;implementation evaluation;implementation research;implementation science;implementation strategy;improved;Infectious Diseases Research;innovation;Interruption;Intervention;Interview;Leadership;Manuscripts;Medicine;Mentors;Methods;mobile application;mobile computing;Modeling;mortality;Myocardial Infarction;Observational Study;patient oriented;Patients;Persons;Pharmaceutical Preparations;Population Attributable Risks;Prevalence;primary outcome;Productivity;programs;Protocols documentation;Qualitative Research;Quasi-experiment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Methodology;Research Personnel;Research Training;Risk Factors;Rural;scale up;Scientist;screening;Series;service delivery;Service delivery model;service providers;Services;skills;Social support;Structure;Taxonomy;Time;Training;treatment guidelines;Treatment Protocols;Uganda;Workload;World Health Organization;Writing

PROJECT_TITLE: Leveraging existing HIV differentiated service delivery models to screen and treat hypertension in Ugandan persons living with HIV for dual control

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative We propose here a new interdisciplinary program in Molecular, Cellular, and Developmental Mechanisms (MCDM) at Harvard Medical School (HMS) that will build on our recent investments in science infrastructure, education, and training. Our goal is to educate a diverse, rigorous, and independent group of scientists who will identify novel essential questions in mechanistic biology and develop incisive tools for addressing them.

PI_NAMEs: VAN VACTOR, DAVID L. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Development;Molecular

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE Immunity generated by acellular pertussis vaccines wanes rapidly, and does not prevent nasal colonization or transmission. We will use state-of-the-art mass spectrometry and bioinformatics tools to identify novel immunogenic proteins from circulating B. pertussis strains that are presented on MHC Class II and recognized by CD4+ T cells. We will evaluate the immunogenicity, protective efficacy and roles in pathogenesis of these proteins using a murine model of Bordetella pertussis infection.

PI_NAMEs: DEORA, RAJENDAR K;DUBEY, PURNIMA  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acellular Vaccines;Adjuvant;Affinity;aluminum sulfate;Antibodies;Antigen Presentation;Antigenic Diversity;Antigens;Bacterial Proteins;Binding;Bioinformatics;bioinformatics tool;Biological Assay;Bordetella pertussis;CD4 Positive T Lymphocytes;Communities;Containment;Coughing;Country;Coupled;Data Set;Dendritic Cells;Disease;Disease Outbreaks;Epitopes;Flow Cytometry;Formulation;Generations;Hemagglutinin;Histocompatibility Antigens Class II;Human;human pathogen;Immune;Immune response;Immune Targeting;Immunity;Immunization;Immunize;immunogenic;immunogenicity;improved;Individual;Infection;Laboratories;Mass Spectrum Analysis;MHC Class II Genes;Modeling;monocyte;mouse model;Mus;mutant;Nasopharynx;Nose;novel;novel vaccines;Pathogenesis;Peptides;pertactin;Pertussis;Pertussis Vaccine;Phenotype;prevent;Process;Proliferating;protective efficacy;Proteins;Proteomics;rational design;Recombinant Proteins;Resistance;respiratory colonization;Respiratory System;response;Role;Safety;T cell response;T-Lymphocyte;Testing;transmission process;Vaccination;vaccination strategy;Vaccine Adjuvant;Vaccine Antigen;vaccine efficacy;vaccine strategy;Vaccines;Whole Cell Vaccine

PROJECT_TITLE: Identification of novel immunogenic proteins from Bordetella pertussis


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative  Caring for a loved one diagnosed with Alzheimer’s Disease is highly stressful. The proposed project will investigate the biobehavioral mechanisms underlying a novel cognitive emotion regulation intervention in unpaid primary caregivers of persons diagnosed with Alzheimer’s Disease or Alzheimer's Disease-Related Dementias (ADRD) by examining how thinking about an emotional stimulus in a more adaptive way can predict changes in health-related behavior via changes in negative affect and psychophysiological health-related biomarkers. This work may hold clinical significance in the development of new interventions to improve emotional health and well-being in caregivers of persons with ADRD.

PI_NAMEs: DENNY, BRYAN THOMAS (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: active control;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Anxiety;Behavior;behavior change;Behavior Therapy;behavioral outcome;biobehavior;Biological Markers;care recipients;Caregiver Burden;caregiver interventions;Caregivers;Caring;Cellular Phone;clinically significant;Cognitive;cognitive reappraisal;coping;cost;Data;Dementia;Dementia caregivers;depressive symptoms;Development;Diagnosis;Disease;Distress;Ecological momentary assessment;Educational Intervention;Effectiveness;efficacy evaluation;efficacy testing;emotion regulation;Emotional;emotional stimulus;Family;Family member;Female;Financial Hardship;follow up assessment;follow-up;Gender;Health;Health behavior;heart rate variability;high risk population;Immune system;improved;Individual;Intervention;intervention effect;Laboratories;loved ones;Major Depressive Disorder;Measures;Mediating;Medicine;Mental Depression;Modeling;Morbidity - disease rate;mortality;Natural History;negative affect;novel;Outcome;Participant;Patient Self-Report;Patients;perceived stress;Personal Satisfaction;Persons;Photoplethysmography;Population;primary caregiver;Process;psychologic;psychological outcomes;Psychopathology;Psychophysiology;Quality of life;Questionnaires;Randomized;Regulation;Reporting;Research;Research Design;Research Personnel;response;Risk;Science;skills;Stress;Telomere Shortening;theories;Thinking;Time;Training;Treatment Efficacy;United States National Institutes of Health;Woman;Work;wound healing

PROJECT_TITLE: Biobehavioral mechanisms of smartphone-based cognitive emotion regulation training for unpaid primary caregivers of persons with Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(02)]