NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Peanut is the most common cause of death from an allergic reaction to food, and epinephrine is the only life- saving treatment available. We found that the severity of allergic reaction to peanut in pediatric patients correlated with intestinal barrier permeability, but we don’t understand how or why this happens. This application will teach us more about the relationship between intestinal permeability and peanut allergy to better diagnose, predict, and treat severe allergic reactions to peanut and other food allergens.

PI_NAMEs: STEINBACH, ERIN C. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Accidents;Address;Adjuvant;Adverse event;Affect;Age;Alleles;Allergic;Allergic Reaction;Allergy to peanuts;Anaphylaxis;ANGPTL4 gene;Animal Model;Apoptosis;Arthritis;Basic Science;Binding;Biological Assay;Biology;Biopsy;C-terminal;Candidate Disease Gene;career;career development;Cause of Death;Cell Cycle;Cells;Cellular biology;Cellular Metabolic Process;Cholesterol;Cholesterol Homeostasis;Chronic;Clinical;cohort;combinatorial;Data;design;Development;Diagnosis;Disease;disease phenotype;Educational process of instructing;effective therapy;Enteral;Epinephrine;Epithelial Cells;epithelial stem cell;Exposure to;FDA approved;Fluorescence Microscopy;Food;food allergen;Food Hypersensitivity;Fostering;Foundations;Functional disorder;gastrointestinal;Gene Expression Regulation;Genomics;Genus Hippocampus;Germ-Free;Gnotobiotic;Grant;gut dysbiosis;gut microbiota;Homeostasis;Human;Hypersensitivity;Immune;Immune Targeting;Immunology;Inbred Mouse;Inflammatory;Injury;Integrins;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Knowledge;large datasets;Learning;Life;Link;lipid metabolism;Maps;Measures;Mediating;medical schools;Medicine;member;Mentors;Metabolism;metabolome;metabolomics;Methods;Microbe;microbial;microbial composition;microbial products;migration;monolayer;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;new therapeutic target;North Carolina;novel;Oral;Oxidative Phosphorylation;Patients;pediatric patients;Pediatrics;Permeability;Persons;Physicians;Predisposition;Production;professor;Program Development;programs;Proliferating;prospective;Reaction;Recombinants;repository;Research;Resources;response;Rheumatology;Rodent;Role;Route;Running;Scientist;Serum;Severities;single-cell RNA sequencing;skills;stem cell function;stem cells;stool sample;sublingual immunotherapy;targeted treatment;tenure track;Tissue Banks;Tissues;Training;transcriptome sequencing;Translational Research;Triglycerides;Universities;Vascular Permeabilities;Work

PROJECT_TITLE: Revealing the mechanisms of increased intestinal epithelial cell barrier permeability in peanut allergy


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Acute myeloid leukemia (AML) driven by oncogenic fusion proteins involving the Nucleoporin 98 (NUP98) gene make up the highest percentage of pediatric patients with relapsed and incurable disease. I recently reported that inhibiting the Menin-MLL1 chromatin complex in NUP98-fusion AML can halt self-renewal and induce myeloid differentiation through transcriptional reprogramming. The goals of this proposal are to define the mechanism by which transcription of pro-leukemogenic genes is maintained by NUP98-fusion proteins and how these loci are epigenetically silenced upon degradation or displacement of NUP98-fusion proteins from chromatin.

PI_NAMEs: HEIKAMP, EMILY  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acute Myelocytic Leukemia;Award;Binding;Biology;C-terminal;cancer type;cell growth;Cells;Child;Chimeric Proteins;Chromatin;chromatin protein;Chromosomal translocation;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computational Biology;CRISPR screen;Dana-Farber Cancer Institute;Data Set;Dedications;Dependence;Disease;Down-Regulation;Early identification;Environment;Enzymes;Epigenetic Process;experience;experimental study;Financial Support;fitness;Fusion Oncogene Proteins;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Models;Genetic Risk;Genetic Transcription;Genotype;Goals;Heterogeneity;high risk;histone modification;improved outcome;in vivo;inhibitor;insight;Laboratory Study;leukemia;Leukemic Cell;leukemogenesis;Lysine;Malignant Neoplasms;Mediating;MEN1 gene;Menin;Mentors;Mentorship;Methods;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;MLL-rearranged leukemia;Modeling;Molecular;Mus;mutant;Myelogenous;novel;NPM1 gene;Nuclear Pore Complex Proteins;Oncogenic;Patient-Focused Outcomes;Patients;pediatric patients;Physicians;PRC1 Protein;Prognosis;programs;promoter;protein degradation;Proteins;Publishing;Relapse;Reporting;Repression;Research;Research Personnel;Resistance;Resolution;Role;Scientist;Screening Result;self-renewal;skills;small molecule;small molecule inhibitor;Specific qualifier value;stem cells;stemness;System;targeted treatment;Therapeutic;therapeutically effective;therapy resistant;Time;Training;Transcriptional Regulation;transcriptional reprogramming;transcriptomics;Work

PROJECT_TITLE: Epigenetic regulators define a dynamic chromatin landscape in NUP98-rearranged leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Chronic hypoxia affects millions of patients with cardiopulmonary diseases such as advanced heart failure and severe chronic lung disease, and is associated with increased morbidity and mortality. The goal of this work is to test the hypothesis that the transcription factor, sterol response element binding protein 1 (SREBP1), is an evolutionarily conserved oxygen sensor in mammals that mediates adaptation to chronic hypoxia by integrating changes in lipid metabolism and low oxygen availability. This work could uncover novel therapeutic targets for conditions that lead to long-term hypoxia, in particular cardiovascular and metabolic diseases.

PI_NAMEs: BAIK, ALAN HYUN (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acute;ADD-1 protein;Affect;Animal Disease Models;Binding;Binding Proteins;Binding Sites;Bioinformatics;biological adaptation to stress;Biology;Buffers;Caenorhabditis elegans;Carbon;Cardiovascular Diseases;career;Cells;ChIP-seq;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Circadian gene expression;Clinical;Communication;Consumption;Cyanotic heart disease;Data;Development Plans;Diet;Disease;DNA Binding;DNA mapping;Eicosapentaenoic Acid;experimental study;Exposure to;Fatty Acids;Fission Yeast;formycin triphosphate;Foundations;functional genomics;Funding;gene network;Genes;Genetic Transcription;Goals;Heart failure;Helix-Turn-Helix Motifs;Hepatocyte;Homeostasis;Homologous Gene;Hour;Hypoxia;Hypoxia Inducible Factor;Impairment;K-Series Research Career Programs;Knockout Mice;Knowledge;Laboratories;Leadership;Leucine Zippers;lipid metabolism;Lipids;Liver;Lower Organism;Lung Diseases;lung hypoxia;Mammalian Cell;Mammals;Measures;Mediating;Mediator;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;microPET/CT;Mitochondrial Diseases;Molecular;Molecular Biology;Monitor;Morbidity - disease rate;mortality;Mus;Nervous System Disorder;new therapeutic target;Nonesterified Fatty Acids;novel;novel therapeutics;Nuclear;Oleates;Organism;Overlapping Genes;oxidation;Oxygen;palm oil;Palmitates;Pathology;Pathway interactions;Patients;Pattern;Persons;Physicians;pi bond;Polyunsaturated Fatty Acids;programs;Promoter Regions;public health relevance;Pulmonary Heart Disease;Pulmonary Hypertension;Radiolabeled;Research;Research Training;response;Response Elements;Role;saturated fat;Saturated Fatty Acids;Scientist;sensor;Signal Pathway;Signal Transduction;skills;Soybeans;SRE-1 binding protein;Sterols;Stress;Structure;Systems Biology;Technical Expertise;Techniques;Testing;Therapeutic;Tissues;Tracer;Training;Training Programs;transcription factor;transcriptome sequencing;Triglycerides;United States;Unsaturated Fatty Acids;Update;uptake;Work;X-Ray Computed Tomography;Yeasts

PROJECT_TITLE: SREBP1 as a Novel Mammalian Oxygen Sensor

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative This research project will provide a better understanding on social networks in late life in the Caribbean, Latin America and the United States and potentially provide evidence for strategic interventions aimed at buffering the effect of migration and transnational family ties. We will examine social network trajectories, its association with health, and project kinship networks for older adults for the coming years; this has the potential to inform more specialized interventions geared towards higher risk older adults, with the goal of reducing health disparities in the aging population.

PI_NAMEs: MATOS-MORENO, AMILCAR  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Adult;Adult Children;Age Years;aged;Aging;aging population;Americas;Birth;Buffers;Cardiovascular Diseases;Caribbean region;Caring;Central American;Characteristics;Chronic;cohort;Collection;Communities;comparative;Costa Rica;Costa Rican;Country;Data;density;Diabetes Mellitus;Dimensions;disability;Economics;Elderly;Ethnic Origin;experience;Face;Family;family structure;Family Study;Funding;Future;Geography;Goals;Health;Health and Retirement Study;Health Promotion;healthy aging;high risk;Hispanic;Individual;informal caregiving;Intervention;Kinship Networks;Knowledge;late life;Latin America;Left;Link;Literature;Longevity;member;Mental Depression;Mentors;Mexican;Mexico;Migrant;migration;Modeling;novel;older adult;Older Population;Out-Migrations;Outcome;Pathway Analysis;Pattern;Personal Satisfaction;Persons;physical conditioning;Policies;Population;Population Pressures;Prevalence;Puerto Rican;Puerto Rico;Race;Reduce health disparities;Reporting;Research;Research Project Grants;residence;Sampling;social;Social Change;social engagement;Social Environment;Social isolation;Social Network;Social support;Societies;socioeconomics;Statistical Methods;stem;Stratification;Structure;Techniques;Time;tool;Training;Typology;United States;Visit;young adult

PROJECT_TITLE: Cross-National Comparisons of Transnational Social Networks and Health among Left Behind Older Adults in the Americas

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Hypoplastic Left Heart Syndrome (HLHS) is a complex form of congenital heart defect caused by a variety of largely unstudied genetic mutations. Here, I propose to study the function of two HLHS-linked genes, RBFOX2 and FOXC2, to understand their mechanisms of action. The results from these studies could lead to new therapeutic inroads to treat HLHS.

PI_NAMEs: HUANG, MENGMENG  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Affect;Alternative Splicing;Animal Model;Animals;aortic valve;ascending aorta;Binding;Biology;Calcium;Cardiac;cardiac tissue engineering;cardiogenesis;Cell Adhesion;cell growth;Cell Nucleus;Cell Size;Circulation;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Management;cohort;Complex;congenital heart abnormality;Congenital Heart Defects;constitutive expression;CRISPR screen;Cytoplasm;Cytoskeleton;Data;data integration;Data Set;Decision Making;Defect;demethylation;Development;differential expression;Disease;Disease Management;DNA Sequence Alteration;Dose;Embryo;Endocardium;Endothelium;Engineering;Event;Extracellular Matrix;Fibronectins;follow-up;FOXC2 gene;gene network;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Heart;heart defect;Heart failure;Heterozygote;Human;human induced pluripotent stem cells;Hypoplastic Left Heart Syndrome;improved;induced pluripotent stem cell;Inherited;Intercellular Junctions;ITGA7 gene;Knock-out;Knowledge;Learning;Left;Left ventricular structure;Lesion;Link;LoxP-flanked allele;Measures;Mediating;Methylation;Mitral Valve;Modeling;Molecular Mechanisms of Action;Molecular Profiling;Morbidity - disease rate;Mus;muscular structure;mutant;Myocardial;Myocardium;Myofibrils;notch protein;novel therapeutics;Operative Surgical Procedures;Orthologous Gene;Oxygen Consumption;Pathogenesis;Pathway interactions;Patients;Phenotype;Physiology;proband;Proteome;Published Database;Publishing;Pump;Quantitative Reverse Transcriptase PCR;Recombinants;Reporter;RNA;RNA methylation;RNA Splicing;RNA-Binding Proteins;Secondary to;Side;Signal Transduction;Spliced Genes;Structural defect;structural heart disease;Structure;Testing;Thinking;Tissues;Transcript;transcription factor;transcriptome;transcriptome sequencing;Transfection;Variant;Zebrafish

PROJECT_TITLE: Deciphering the intrinsic myocardial and/or endocardial defects of hypoplastic left heart syndrome

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Poor sleep health, including insufficient duration of sleep and chronic insomnia, have been associated with a myriad of negative health outcomes including risk for cognitive decline and Alzheimer’s disease. To better understand the biological mechanisms through which sleep, specifically short sleep duration and insomnia, influences the risk of Alzheimer’s disease, we propose to analyze data from several large population-based studies to identify the effects of short sleep and insomnia on multi-omic profiles. This approach incorporates multi-omics measures (methylation, metabolomics, and blood-based biomarkers for Alzheimer’s disease) and causal analysis (Mendelian randomization) to address gaps in our current knowledge concerning molecular mechanisms associated with insufficient sleep and neurodegenerative disease, further extending this to an experimental partial sleep deprivation paradigm to understand how restricting sleep alters the metabolomic and Alzheimer’s disease biomarkers of neurodegeneration and could inform future research on potential therapeutic targets.

PI_NAMEs: KUSTERS, CYNTHIA DIANA JOHANNA (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Bioinformatics;bioinformatics tool;Biological;Biological Aging;Biological Markers;biomarker identification;Biometry;Blood;blood-based biomarker;candidate marker;cardiovascular disorder risk;Cerebrospinal Fluid;Chronic Insomnia;cognitive function;Collaborations;complex data;Data;Data Analytics;Development;DNA Damage;DNA Methylation;Endocrinology;Enrollment;epigenetic aging;ethnic diversity;Etiology;Exhibits;Experimental Designs;experimental study;Genetic;genetic analysis;Glial Fibrillary Acidic Protein;glymphatic system;Health;health disparity;high risk;Hispanic Community Health Study;Hispanic Populations;Image;Impaired cognition;Individual;Inflammation;Inflammatory;innovation;insight;interdisciplinary approach;Knowledge;Light;Link;Literature;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Metabolic;metabolomics;Methodology;Methylation;Molecular;multiple omics;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Pathway interactions;Phenotype;Plasma;polygenic risk score;poor sleep;Population;Population Heterogeneity;Population Study;Process;protein aggregation;Research;response;Risk;Risk Marker;Sample Size;Science;skills;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;Sleeplessness;Subgroup;therapeutic target;Training

PROJECT_TITLE: Biological pathways linking sleep health to Alzheimers disease and cognitive decline


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE While screening has been shown to reduce mortality from colorectal (CRC) and breast cancer (BC), screening uptake remains low among Chinese immigrant women, a group in whom CRC and BC are leading causes of preventable death. The goal of this study is to develop a socio-culturally sensitive, community-engaged intervention to improve CRC and BC screening in Chinese immigrant women and to test its preliminary impact through a pilot randomized controlled trial. These findings will provide proof-of-concept for an integrated approach to comprehensive cancer screening participation and will improve access, delivery, and outcomes for underserved and underrepresented communities.

PI_NAMEs: WANG, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;Area;arm;Asian;Asian Americans;attentional control;Attitude;barrier to care;Belief;Benchmarking;Biometry;Breast Cancer Detection;Breast Cancer survivor;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;career development;caucasian American;Cause of Death;Cervical;Cessation of life;Chinese;Chinese American;clinical care;Colorectal;Colorectal Cancer;colorectal cancer screening;Communities;community based research;Community Developments;community engaged intervention;Community Health Aides;community intervention;Comparative Effectiveness Research;Complex;Data;design;Development;Disadvantaged;Disease Management;Education;Effectiveness;Eligibility Determination;Environment;ethnic diversity;Evaluation;evidence base;Evidence based intervention;experience;Face;Feedback;Filipino;Filipino American;Focus Groups;Funding;future implementation;Gastroenterologist;Gastroenterology;Generations;Goals;Grant;Health;health assessment;health belief;health care availability;health care delivery;health communication;health equity;Health Services;Immigrant;Improve Access;improved;Incidence;Individual;Informal Social Control;innovation;Insurance;Internal Medicine;Intervention;intervention delivery;Interview;Language;Leadership;Linguistics;Literature;Lung;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Manuscripts;medical schools;medically underserved;Medicine;Mentors;Methodology;Minority Groups;Modeling;mortality;multi-component intervention;multidisciplinary;news;Not Hispanic or Latino;Outcome;outreach;patient oriented;patient-level barriers;Patients;peer;Persons;poor health outcome;Positioning Attribute;post intervention;Preventable cancer cause;preventable death;Prevention;Prevention program;programs;Provider;provider-level barriers;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Infrastructure;Research Personnel;Scholarship;screening;screening disparities;Screening for cancer;screening participation;skills;social culture;social stigma;Structure;System;Testing;Time;Training Activity;underserved community;Underserved Population;United States;United States National Institutes of Health;uptake;Vulnerable Populations;Woman;Writing

PROJECT_TITLE: Chi gung: a community-based strategy in Chinese immigrant women to improve colorectal and breast cancer screening.


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurosciences;Nutrition;Obesity

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance Obesity is a major risk factor for type II diabetes and accounts for a significant proportion of healthcare costs in the United States and other developed countries. Identifying accessible therapeutic targets is key to searching for treatments for this metabolic disorder. In this proposal, we will investigate the fine regulation of the sensitivity of the brain regions regulating energy balance to drugs with limited use in the clinic by a novel target that may represent a safe and effective way to treat obesity.

PI_NAMEs: HERNANDEZ, CIRIA C (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Acute;Adverse drug effect;Agonist;Alleles;analog;Appetite Stimulants;Area;Attenuated;Basic Science;Body Weight;Brain;Brain region;Cell Nucleus;Cells;channel blockers;Characteristics;Clinic;Clinical Research;Data;Developed Countries;Developing Countries;Development;dietary;Disease;Dose;Drug Targeting;early-onset obesity;Eating;Eating Behavior;Eating Disorders;energy balance;Energy Metabolism;Feedback;feeding;Feeding behaviors;Food Energy;Genes;Genetic;genetic approach;Genetic Induction;Genetic Recombination;Glutamates;GTP-Binding Proteins;Health Care Costs;Hemostatic function;Homeostasis;Human;Hyperphagia;Hypothalamic structure;Incidence;insight;inward rectifier potassium channel;Kir7.1 channel;Lesion;Ligand Binding;Maps;Melanocortin 4 Receptor;melanocortin receptor;Metabolic Diseases;Metabolism;Molecular;mouse model;Mus;neural circuit;neuronal excitability;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;optogenetics;Output;pandemic disease;paraventricular nucleus;Pathway interactions;Pattern;Peptides;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Potassium Channel;Pro-Opiomelanocortin;Property;Public Health;public health relevance;receptor;Regulation;Reporter;response;restoration;Risk Factors;Role;Satiation;Signal Transduction;Site;Stimulus;Structure of nucleus infundibularis hypothalami;Synapses;System;therapeutic target;Tissues;transcriptomics;transmission process;United States;Visualization;Weight Gain;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: The inward rectifier potassium channel Kir7.1 is at the center of energy homeostasis regulation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Dental adhesives are employed to create a sturdy and long-lasting bond between dentin and composite restorations, through the formation of a robust hybrid layer comprised of a three-dimensional polymer network that interlocks with native bone tissue. To date, the performance of such adhesives is sub-optimal, as the majority of composite failures are observed at restoration margins. The fundamental goal of this project is to understand the phase structure and composition of heterogeneities that form during adhesive polymerization, and to reinforce weakened regions of the hybrid layer through the development and application of monomers capable of adaptable, dynamic bond rearrangement.

PI_NAMEs: SZCZEPANSKI, CAROLINE ROSE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adhesive polymer;Adhesives;Amalgam;analog;Appearance;Appointment;Award;Bacteria;Behavior;Biocompatible Materials;Biological;biomaterial compatibility;Bone Tissue;career;career development;Catechols;Categories;chemical group;Chicago;Clinical;Complex;composite restoration;cost;dental adhesive;Dental Materials;Dental Schools;Dentin;design;Development;Development Plans;driving force;efficacy evaluation;Ensure;Environment;Esthetics;Exposure to;Failure;Fatigue;Formulation;Funding;Goals;Growth;Healthcare;Heterogeneity;Hybrids;Hydrogen Bonding;Illinois;improved;Infiltration;innovation;Institution;Investigation;Laboratory Research;Longevity;mechanical properties;Mechanical Stress;Mechanics;Medicine;Mentors;Mentorship;Methacrylates;Michigan;Modeling;monomer;Morphology;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Patient Care;Patients;Performance;Phase;photopolymerization;Plant Resins;polymerization;Polymers;Positioning Attribute;Postdoctoral Fellow;Predisposition;programs;Protocols documentation;Pyrimidinones;Recovery;Relaxation;Research;research and development;Research Personnel;Research Project Grants;response;responsible research conduct;restoration;restorative dentistry;restorative material;Route;Science;Series;skills;Specimen;Stress;Structure;success;System;Testing;Training;United States;United States National Institutes of Health;Universities;uptake;Water;Work

PROJECT_TITLE: Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Youth in foster care have unique experiences and significantly higher trauma load which greatly increase their risk for a range of negative social, behavioral, academic, physical and mental health outcomes, and may benefit from skilled caregiver intervention. This project aims to identify modifiable risk and protective factors that can be targeted through the caregiving context, elucidate areas in which foster parents desire additional parent training to support the kids in their care, and evaluate the barriers and facilitators to current parent trainings, to inform future intervention development. This K08 award will provide cutting edge training in quantitative, qualitative, and intervention development methods and will position the PI to lead federally funded multidisciplinary studies with translational implications for populations of youth who experience trauma and/or parental separation.

PI_NAMEs: WRIGHT, ANNA WATERS (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adolescent;Adopted;Area;Award;Behavioral;Birth;caregiver interventions;Caregivers;caregiving;Caring;Child;Child Rearing;Child Welfare;Clinical;Communities;community intervention;Data;Data Analyses;Development;Documentation;Educational Intervention;Emotional Intelligence;Environment;Environmental Risk Factor;Evaluation;experience;Exposure to;Family;foster care;foster child;foster parent;Fostering;Frequencies;Funding;Future;Goals;Health;Heterogeneity;high risk;implementation context;improved;Influentials;Institution;Intervention;Interview;Investigation;Lead;Learning;Link;longitudinal analysis;Mental Health;Mentorship;method development;Methods;modifiable risk;multidisciplinary;multimodality;National Institute of Child Health and Human Development;Outcome;parenting intervention;Parents;Participant;Perception;physical conditioning;Policies;Population;Positioning Attribute;Prevention;programs;protective factors;psychosocial;psychosocial outcome;Qualitative Methods;Qualitative Research;Race;Reduce health disparities;Research;Research Methodology;Research Personnel;resilience factor;Risk;Risk Factors;Series;Services;skills;social;social health determinants;Social Problems;social skills;Socialization;Statistical Data Interpretation;Structure;System;Techniques;therapy development;Thinking;Training;Trauma;traumatized children;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Practices of Foster Caregivers and the Developmental Outcomes of Youth in Foster Care: A Multi-Method Investigation

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Secondary ischemic and cytotoxic cell damage increases disability and undermines recovery potential in patients with traumatic spinal cord injuries (SCI). This proposal builds from well-studied animal models and seeks to validate, in human subjects, that cerebral spinal fluid serotonin and adenosine are sensitive biomarkers to detecting secondary injuries. This proposal represents the first step in establishing effective treatment strategies to limit secondary injury and improve long- term outcomes in SCI patients.

PI_NAMEs: FIELDS, DARYL  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Acute;Adenosine;Animal Model;Apoptotic;Award;biobank;Biological Markers;biomarker identification;Blood gas;blood product;Brain Stem;career;career development;Caring;Cell Hypoxia;cell injury;Cellular Stress;Cellular Structures;Cerebrospinal Fluid;Cessation of life;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;comparative efficacy;cytokine;cytotoxic;Data;Detection;Diagnostic;Diameter;disability;Disease;Drainage procedure;Early Intervention;Edema;effective therapy;efficacy evaluation;Environment;Equipment and Supplies;Evaluation;Exhibits;extracellular;Future;gastrointestinal;Grant;Hematoma;High Pressure Liquid Chromatography;Hour;Human;human subject;hypoperfusion;Hypoxemia;Hypoxia;Image;Impairment;improved;Incidence;Inflammation;Inflammatory;Infrastructure;Injury;Institution;Intervention;Iron;Ischemia;ischemic injury;Knowledge;Laceration;Lead;Learning;Long term disability;Magnetic Resonance Imaging;Measures;Mechanics;Mentorship;Methodology;Modeling;Molecular;molecular marker;Monitor;Motor;motor deficit;Natural Killer Cells;Nervous System Trauma;neuromuscular;Neurons;Neurosurgeon;Outcome;Patients;Performance;Perfusion;Phase;Physiological;post-doctoral training;pressure;prevent;programs;prospective;Prospective Studies;Protocols documentation;psychosocial;Pulse Oximetry;Quality of life;raphe nuclei;Recovery;recruit;Rehabilitation therapy;Research;respiratory;Risk;Rodent;Rodent Model;Sampling;Scientist;Sensory;Serotonin;Severities;Signal Transduction;skills;small molecule;Spinal;Spinal cord injury;Spinal cord injury patients;Stress;Structure;Synapses;Testing;theories;Time;tissue injury;Tissues;tool;Training;translational clinical trial;treatment response;treatment strategy;trend;Varicosity;Work;Writing

PROJECT_TITLE: Cerebral spinal fluid serotonin and adenosine levels detect secondary injuries in traumatic spinal cord injury patients

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Organ Transplantation;Pediatric;Physical Activity;Prevention;Social Determinants of Health;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The long-term survival of pediatric heart transplant (HT) patients remains unacceptably low and is limited in part by modifiable cardiovascular risk factors. Increasing moderate to vigorous physical activity (MVPA) improves cardiovascular health in these children, but efforts to do so effectively and equitably are hindered by the lack of an understanding of the environmental associations with MVPA. This proposal seeks to use quantitative and qualitative methods to assess the macro and micro environmental determinants of MVPA in pediatric HT and to design and evaluate a pilot study of a longitudinal multi-component exercise intervention.

PI_NAMEs: EDELSON, JONATHAN BUNIVA (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;Address;Aerobic;Age;Allografting;Area;Attitude;Award;Behavior;behavior change;Cardiac;cardiovascular health;cardiovascular risk factor;Censuses;Characteristics;Child;Childhood;Chronic Kidney Failure;Clinical;cohort;comorbidity;Coronary;Data;deprivation;design;Development;Diabetes Mellitus;Diagnosis;digital;Dyslipidemias;efficacy outcomes;Enrollment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Equity;Exercise;exercise capacity;exercise intervention;exercise program;Exposure to;Family;fitbit;Future;Goals;Green space;Habits;Health;Health Technology;Heart Diseases;Heart Transplantation;Home;Hypertension;implementation framework;implementation science;improved;improved outcome;indexing;Individual;Inequity;innovation;Interval training;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Link;Maps;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;mHealth;Modeling;moderate-to-vigorous physical activity;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;Movement;multi-component intervention;multiphase optimization strategy;neighborhood association;Neighborhoods;novel;Outcome;Parents;Participant;Pathway interactions;Patients;Pattern;pediatric cardiologist;Persons;Physical activity;Physicians;Pilot Projects;Population;Positioning Attribute;programs;prospective;Public Health;Qualitative Methods;Quality of life;Research Personnel;Rewards;Scientist;Site;skills;smart watch;socioeconomics;Structure;Testing;theories;therapy design;therapy development;Time;Training;Transplant Recipients;Vascular Diseases;Vulnerable Populations;walkability;wearable device;Work;Youth

PROJECT_TITLE: MIGHTIER: Movement in Heart Transplant patients: the Impact of Environmental factoRs

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Neurons in our brains communicate by releasing small molecules that impact the function of neighboring cells. Changes in this communication – for example, altering what molecules are released, which cells feel their effect, and how strongly they respond – underlie our ability to learn new skills, form memories, and adapt to our changing environment whereas pathological changes underlie many neurological diseases. We have uncovered many surprising and unknown aspects of neuronal communication, which will be studied here in an effort to understand brain function in normal and disease states.

PI_NAMEs: SABATINI, BERNARDO L (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: basal forebrain;Behavior;Binding;Biochemical;Brain;Cells;cholinergic;Communication;Disease;endopeduncular nucleus;Endowment;Environment;Funding;gamma-Aminobutyric Acid;Glutamates;Interneurons;Learning;Link;Memory;Methods;Midbrain structure;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neuromodulator;Neurons;neuroregulation;neurotransmission;neurotransmitter release;Neurotransmitters;Pathologic;postsynaptic;Property;receptor;Research;Signaling Molecule;skills;small molecule;Somatostatin;Structure;Synapses;Synaptic Transmission;Vasoactive Intestinal Peptide

PROJECT_TITLE: Action and Interaction of Neurotransmitters and Neuromodulators

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (35)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Otitis Media;Pediatric;Prevention;Vaccine Related

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Narrative An unmet clinical need for the prevention of acute otitis media is a vaccine that can target multiple otopathogens simultaneously in a strain independent manner while engendering protective immunity at the mucosal surface. We have addressed this via the generation of a novel, recombinant live attenuated vaccine strain platform that can be modified to express protective epitopes from multiple bacterial species to confer protective mucosal immunity. We plan to utilize this platform to explore the protective capacity and correlates of protections for a trivalent otitis media vaccine targeting Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

PI_NAMEs: ROSCH, JASON W. (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Address;Animal Model;Antibiotics;Antibody Response;Antigens;Attenuated Vaccines;Bacterial Model;Bacterial Vaccines;Binding;capsule;Cell surface;Child;Choline;Clinical;combinatorial;design;Development;Engineering;Epitopes;Excision;Generations;Goals;Haemophilus influenzae;Haemophilus influenzae type b;Immune;Immunity;Incidence;Individual;Infection;interest;Licensing;Lipoproteins;Lung;Lung infections;middle ear;Modeling;Modification;Moraxella catarrhalis;mouse model;Mucosal Immunity;Mucous Membrane;Names;Nontypable Haemophilus influenza;Nose;novel;novel strategies;Otitis;Otitis Media;pathogen;pediatrician;Pneumococcal Infections;prevent;Prevention;progenitor;protective efficacy;Proteins;Recombinants;response;Serotyping;Severities;sortase;Streptococcus pneumoniae;Surface;Testing;Vaccination;vaccine candidate;vaccine platform;Vaccines;Viral;Visit;Work

PROJECT_TITLE: Trivalent Live Attenuated Vaccines for Bacterial Acute Otitis Media

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

PHR: PROJECT NARRATIVE I have used CRISPR/Cas9 technology to create a new human cell-based experimental model for Diamond– Blackfan anemia (DBA), a rare but devastating blood disease that causes isolated anemia in children and global suppression of blood formation in many older patients. Using my new approach, I showed that the mutations in RPS19, the most commonly affected gene in DBA, impair the function of blood-repopulating hematopoietic stem cells (HSCs). My planned project to study this impairment should lead to improved understanding of DBA, identify new therapeutic strategies, and elucidate a new facet of ribosomal and HSC biology.

PI_NAMEs: BHOOPALAN, SENTHIL VELAN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acceleration;Address;Affect;Allogeneic Bone Marrow Transplantation;Anemia;Animal Model;Biological Assay;Biology;Blood;blood formation;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;career;career development;CD34 gene;Cell Maintenance;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;cofactor;Complex;CRISPR/Cas technology;cytopenia;Data;Defect;Development;Diamond-Blackfan anemia;Disease;effective therapy;Environment;Epigenetic Process;Erythrocyte Transfusion;Erythroid;Erythropoiesis;Exhibits;Experimental Models;Failure;Foundations;Functional disorder;Funding;Future;Gene Expression;Gene Proteins;gene therapy;Genes;Genetic Transcription;Glucocorticoids;Goals;Hematological Disease;Hematopoiesis;hematopoietic differentiation;hematopoietic hierarchy;Hematopoietic stem cells;Heterozygote;Human;human model;Immunodeficient Mouse;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;infancy;Inherited bone marrow failure;insight;Investigation;Laboratories;loss of function mutation;Loss of Heterozygosity;Maintenance;Maps;MDM2 gene;Mediating;Mentorship;Methods;Modeling;Molecular;Mutation;Myelopoiesis;novel strategies;novel therapeutic intervention;novel therapeutics;older patient;Pathway interactions;Patients;Phase;Phenotype;Physicians;Physiology;Polycomb;Population;Population Heterogeneity;Process;Production;progenitor;programs;Protein Deficiency;Protein Subunits;Repression;Repressor Proteins;Research;Ribonucleoproteins;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;ribosomopathy;RPS19 gene;Scientist;self-renewal;single-cell RNA sequencing;Spectrum Analysis;stem cell biology;stem cell function;Structure;Testing;Therapeutic;TP53 gene;Training;transcriptome;transcriptome sequencing;transcriptomics;Translations;translatome;Transplantation;transplantation therapy;ubiquitin ligase;United States National Institutes of Health;Western Blotting;Xenograft procedure

PROJECT_TITLE: Hematopoietic stem cell defects in Diamond-Blackfan Anemia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Opioid use disorder is a highly prevalent and devastating disorder with the necessity to develop more effective treatments. Emerging evidence from epidemiological and clinical studies have provided strong evidence for an association between sleep alterations, circadian rhythm disruptions, and opioid use disorder, as sleep and circadian dysfunction increase the risk for relapse. This proposal will identify transcriptional rhythm alterations in the brains of people with opioid use disorder at the single cell level within a major neural substrate of reward and motivation, the nucleus accumbens, which will provide new insights into the putative mechanisms of opioid use disorder, with the potential of opening the door to development of new circadian-dependent therapeutic strategies.

PI_NAMEs: LOGAN, RYAN W (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;Address;Age;Arousal;Astrocytes;Atlases;Autopsy;Biological;Brain;cell type;Cells;Cessation of life;Chromium;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical Research;Cluster Analysis;cohort;computerized tools;Corpus striatum structure;craving;Data;Data Set;Development;Disease;Dopamine;Dopamine Receptor;effective therapy;epidemiology study;Exhibits;Experimental Designs;Feedback;Female;Foundations;Freezing;Functional disorder;Future;Gene Combinations;Gene Expression;Gene Expression Profile;Genetic Transcription;Genome;Genomics;glutamatergic signaling;Hour;Human;imaging study;innovation;insight;Interneurons;Knowledge;male;Maps;Measures;Mental disorders;Molecular;Motivation;neural;neurobiological mechanism;Neurons;novel;Nucleus Accumbens;Opioid;opioid mortality;opioid use;opioid use disorder;Pathway interactions;Patients;Pattern;Persons;Phase;Prevalence;protein expression;Regulation;Relapse;relapse risk;Reporting;Rewards;Risk;Rodent;Rodent Model;sequencing platform;Series;sex;sex variable;single cell technology;single nucleus RNA-sequencing;Sleep;Sleep Disorders;System;Therapeutic;time use;Tissues;Transcript;Transcription Alteration;transcriptomics;United States;Variant;Withdrawal;Work

PROJECT_TITLE: Single-cell molecular rhythm alterations in human nucleus accumbens associated with opioid use disorder

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Diabetes;Prevention;Rehabilitation;Women's Health Research

PHR: Project Narrative Type 2 diabetes is a major source of morbidity and mortality in breast cancer survivors, the largest cancer survivor group, in whom diabetes management is challenging due to unique characteristics (related to cancer and its treatments) that alter the harm/benefit ratio of different diabetes treatment strategies. I plan to develop a simulation model tailored to breast cancer survivors with type 2 diabetes and subsequently perform comparative effectiveness of differing diabetes treatment strategies in this population. My results will improve the management and outcomes, in terms of reducing diabetes complications and maximizing survival and quality of life, of breast cancer survivors with type 2 diabetes.

PI_NAMEs: LEITER, AMANDA CANDICE (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Address;Adult;Age;Agonist;Big Data;Biometry;breast cancer progression;breast cancer survival;Breast Cancer survivor;Breast Cancer therapy;Breast Cancer Treatment;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;career;career development;Cause of Death;Characteristics;chemotherapy;Clinical;Clinical Data;Communication;comorbidity;comparative effectiveness;Complex;Complications of Diabetes Mellitus;Country;Data;data imputation;Data Set;Development;diabetes management;Diabetes Mellitus;diverse data;effective therapy;Endocrinologist;Epidemiologic Methods;Epidemiology;Exclusion;experience;GLP-I receptor;Glucose;glycemic control;Goals;Grant;Guidelines;Hemoglobin;Hypoglycemia;improved;in silico;inhibitor;innovation;Insulin;Kidney;Kidney Diseases;Knowledge;Leadership;Life Expectancy;Link;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mentorship;Metformin;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality risk;Natural History;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Outcome;overtreatment;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Population;Prevalence;Prognosis;Quality of life;Quality-Adjusted Life Years;Randomized, Controlled Trials;Recommendation;Regimen;Research;research and development;Research Personnel;Risk;Safety;screening;shared decision making;skills;Sodium;Source;Statistical Methods;success;Survivors;symporter;Techniques;Training;Translations;treatment comparison;treatment strategy;trial comparing;Uncertainty;Writing

PROJECT_TITLE: Optimizing diabetes treatment strategies in complex comorbidity

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Genetics;Microbiome

PHR: Narrative A fundamental aspect of the success of Streptococcus pneumoniae as a human pathogen is the ability to successfully transmit and infect new hosts, however the mechanisms underlying transmission are complex. We hypothesize transmission is controlled via a specific, uncharacterized two-component regulatory system (TCS11), which is expressed upon epithelial contact and drives expression of a coupled bacteriocin secretion system. We expect that TCS11 mediates pneumococcal transmission via coordination of transmission factor gene expression coupled with bacteriocin production to effectively compete against the respiratory microbiota at the initial stages of epithelial colonization.

PI_NAMEs: MARGOLIS, ELISA B H;ROSCH, JASON W. (contact)

PROJECT_TERMS: Address;airway epithelium;bacteriocin;Biology;Coculture Techniques;Complex;Coupled;Data;Data Set;Databases;Defect;Environment;Epithelial Cells;Epithelium;experimental study;Ferrets;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;genome analysis;Genomics;Human;human pathogen;Hypothetical Protein;In Vitro;insight;Integration Host Factors;interest;Link;Mediating;microbiota composition;Mining;Mus;mutant;nasal microbiota;Operon;pan-genome;pathogen;Play;Process;Production;Publishing;Regulation;Regulon;Resistance;respiratory microbiota;Respiratory System;response;Role;Serotyping;Severity of illness;Signal Transduction;Species Specificity;Specificity;Streptococcus pneumoniae;Structure;success;System;Testing;Toxic effect;transcriptome sequencing;transmission process;transposon sequencing

PROJECT_TITLE: Characterization of TCS11 in Streptococcus pneumoniae

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Microbiome

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This research will further our understanding of certain common bacteria which reside within our intestines throughout our lifetime, and how some of these bugs in particular can make our immune system more aggressive. By researching the way these bacteria “communicate” to our immune system, it may be feasible to pick the correct ones to package together as a probiotic. Such a medication could help cancer patients who want their immune system to behave aggressively against their growing tumor.

PI_NAMEs: UPADHYAY, RABI  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Alternative Splicing;Ampicillin;Anatomy;Animals;Antibiotics;Antigen Mimicry;Antigen Presentation;antitumor effect;Antitumor Response;ATAC-seq;Bacteria;bacterial lysate;Bacteroides;Biomedical Engineering;Blood;Blood flow;Cancer Center;Cancer Patient;Cannulations;career;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Circulation;Clinical Research;clinical training;Communication;Cytotoxic T-Lymphocytes;Disease;Disease remission;Distant;draining lymph node;efficacy testing;Elements;Environment;Epigenetic Process;Exhibits;fecal transplantation;Flow Cytometry;Funding;Gene Expression Alteration;Generations;Genetic Transcription;Germ-Free;gut colonization;gut microbiota;Gut Mucosa;Histology;House mice;Human;Immune;immune checkpoint blockade;Immune response;Immune system;immunogenic;Immunology;Immunotherapy;Implant;improved;In Situ;Inflammatory;Institution;Interleukin-10;International;Intestinal Mucosa;Intestines;Intraperitoneal Injections;Laboratories;Lamina Propria;Lung Neoplasms;Lymphocyte;Malignant neoplasm of lung;Manuals;Mediating;Medical Oncology;medical schools;Medicine;Mentorship;mesenteric lymph node;microbial products;Microbiology;microbiota;Microfluidics;Microscopic;Modeling;monocyte;mouse model;Mucous Membrane;Mus;mutant;neoantigens;neoplastic cell;next generation;Oral;Parabiosis;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Positioning Attribute;pre-clinical;Probiotics;professor;programs;Relapse;Reporting;Research;Research Personnel;Route;Scientist;single cell mRNA sequencing;Sorting;System;T cell receptor repertoire sequencing;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Training;transcriptome sequencing;tumor;Tumor Immunity;tumor microenvironment;Visualization;Work

PROJECT_TITLE: Harnessing human gut-derived Bacteroides to drive systemic anti-tumor immunity


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Sepsis

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This K08 Career Development Award Proposal describes the skills and further training that the PI, Dr. Nicholas P. Semenkovich, M.D., Ph.D., will develop over the next five years to become an independent physician scientist with unique expertise in sepsis and applications of liquid biopsy cell-free DNA as a predictive and prognostic biomarker. Successful accomplishment of the proposed aims will establish a new paradigm for the study of sepsis over its temporal presentation, including its catastrophic complications, and will define a new framework for triage, management, and potential early intervention. Furthermore, the mentorship and training plan serve to develop a candidate with expertise in basic science research and clinical acumen, a combination that is critically important for future translational breakthroughs.

PI_NAMEs: SEMENKOVICH, NICHOLAS P (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Acute;Advisory Committees;Age;Alveolar;Award;Basic Science;Biological Markers;Biopsy;Blood;Body System;career;Cell Fraction;cell free DNA;cell injury;Cell Separation;Cells;Cessation of life;Circulation;Clinical;clinical training;Clinical Trials;Computer Models;Creatinine;Critical Care;Data;Data Set;Dedications;deep learning algorithm;design;Detection;Diagnosis;Diagnostic;Dietary intake;Diffuse;Disease;DNA;DNA analysis;DNA Methylation;DNA methylation profiling;Doctor of Medicine;Doctor of Philosophy;Early identification;Early Intervention;Early intervention trials;early phase clinical trial;Endocrinology;Enrollment;Epigenetic Process;Event;exhaust;exhaustion;experimental study;Faculty;Fingerprint;Five-Year Plans;Frustration;Functional disorder;Future;Goals;gut microbiome;Hospitals;Image;Immune;Immunology;Immunophenotyping;immunoregulation;in silico;In Vitro;in vivo;Individual;insight;Institution;Internal Medicine;International;Intervention;Intestines;K-Series Research Career Programs;Kidney;Kinetics;Left;liquid biopsy;Literature;lung injury;Machine Learning;machine learning method;Malignant Neoplasms;Mentors;Mentorship;Methods;Methylation;methylation pattern;microbial;Modeling;Modernization;Monitor;muscle form;novel;novel marker;Opportunistic Infections;Organ;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Physicians;Population;predictive marker;Prognosis;prognostic;Prognostic Factor;Prognostic Marker;prognostication;prospective;Recovery;Renal function;Research;Research Personnel;Resources;Risk;risk prediction model;Role;Sampling;Scientist;Sepsis;septic patients;Series;Severities;skills;Sorting;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;Tissue Banks;Tissues;Training;translational potential;Triage;Tube;United States;Universities;Vision;Vocational Guidance;Washington;whole genome;Woman;Work

PROJECT_TITLE: Liquid biopsy cell-free DNA analysis to monitor sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Dissemination and Implementation Research;Endometriosis;Pain Research;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Despite the pervasiveness of endometriosis, and its high societal and individual cost, effective non- pharmacologic interventions for endometriosis are lacking. The central goal of this proposal is to determine effectiveness of PEEPS, a new interdisciplinary and integrative group care treatment model. PEEPS is highly relevant to public health as it addresses a costly and common condition in a patient-centered way, and seeks to understand how to most effectively implement PEEPS in real-world practice.

PI_NAMEs: ROSS, WHITNEY TROTTER (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;arm;assigned female at birth;associated symptom;Belief;Bladder;Caring;Characteristics;chronic pain;chronic painful condition;chronic pelvic pain;Clinical;clinical practice;Collaborations;common symptom;community advisory board;community engaged research;community engagement;Consolidated Framework for Implementation Research;coping;cost;Data;depressive symptoms;design;Development;Discipline of obstetrics;Disease;Economic Burden;Education;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;emotional functioning;empowerment;endometriosis;Evaluation;evidence base;Evidence based intervention;experience;Feedback;Female;fertility preservation;Focus Groups;Funding;Goals;Gynecologist;Gynecology;Health Care Visit;Health Expenditures;hormone therapy;Hour;household productivity;Impairment;implementation context;implementation determinants;implementation evaluation;implementation outcomes;implementation science;improved;Individual;Infertility;innovation;instructor;integrated care;Intervention;intervention effect;Interview;Intestines;Knowledge;Life;Measures;mindfulness;mindfulness intervention;Modeling;Mood Disorders;multimodality;Musculoskeletal Pain;Nonpharmacologic Therapy;nutrition;Operative Surgical Procedures;Outcome;Pain;pain catastrophizing;Pain interference;Pain quality;pain symptom;Participant;participant enrollment;patient oriented;Patient Outcomes Assessments;patient population;Patients;peer;Pelvic Pain;Persons;Physical activity;Physical Function;physical therapist;Physical therapy;pilot trial;Positioning Attribute;prevent;Probability;Process;programs;Provider;Psychologist;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recurrence;Reproductive Health;Research;Research Methodology;scale up;Self Efficacy;Severities;Site;Social isolation;Specialist;success;Surveys;Symptoms;Testing;Translating;Translations;treatment as usual;Universities;Washington;Woman;Workplace;Yoga

PROJECT_TITLE: Interdisciplinary group care for the treatment of endometriosis-associated pain

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE For the 1 in 5 patients hospitalized with diabetes, hypoglycemia, the most common adverse side effect of insulin, can be life-threatening. This research expands upon previous work to use artificial intelligence to predict and prevent hypoglycemia. The goal is to develop a clinical decision support tool for use in the electronic health record that increases the safety of care for patients with diabetes.

PI_NAMEs: WRIGHT, AILEEN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Academic Medical Centers;acute coronary syndrome;Adult;Algorithms;Area;Artificial Intelligence;Award;biomedical informatics;Blood Glucose;burnout;Cardiovascular system;career;career development;Caring;Cessation of life;Clinical;clinical decision support;Clinical Medicine;clinical predictive model;clinically relevant;cognitive load;Collaborations;Coma;Complication;Dangerousness;Data;Data Scientist;Data Set;deep learning;design;Development;Diabetes Mellitus;Diagnosis;Drug Interactions;Electronic Health Record;Ensure;Event;experience;falls;Fatigue;Fellowship;forging;Foundations;General Practices;Goals;Harm Reduction;Healthcare;high risk;Hospitalization;Hour;human centered design;Hypoglycemia;improved;Informatics;Inpatients;Institution;instructor;Insulin;Internal Medicine;K-Series Research Career Programs;Laboratories;Length of Stay;Life;Lifting;Machine Learning;machine learning method;machine learning prediction algorithm;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;mortality;Outcome;Patient Care;Patient risk;Patients;Performance;Pharmaceutical Preparations;Physicians;prediction algorithm;predictive modeling;Predictive Value;prevent;Process;prospective;Publishing;Quality of Care;Regimen;Research;research and development;Research Personnel;Risk;Safety;Scientist;Seizures;side effect;skills;Stroke;support tools;Techniques;tool;Translating;Trees;Validation;Work;Workload

PROJECT_TITLE: Artificial Intelligence-Assisted Clinical Decision Support for Preventing Hypoglycemia in Hospitalized Patients


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is intended to fulfill a significant unmet need, namely, an actionable therapeutic approach for reducing the excess risk of cardiovascular disease in type 1 diabetes. If adjunct-to-insulin therapies successfully improve insulin clearance, peripheral hyperinsulinemia, and insulin resistance, it could revolutionize the type 1 diabetes treatment paradigm. The project is relevant to the NIDDK mission as it pertains to supporting diabetes research and research training to improve people’s health and quality of life.

PI_NAMEs: BOEDER, SCHAFER CALE (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: absorption;Address;Adipose tissue;Affect;antagonist;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career development;Chronic;Circulation;Cross-Over Studies;Data;Diabetes Mellitus;Disease;Dose;Double-Blind Method;experience;Fasting;Glucagon Receptor;Glucose;Glucose Clamp;glycemic control;Goals;Health;Hepatic;Hormonal;Human;hyperglucagonemia;Hyperinsulinism;Impairment;improved;Indirect Calorimetry;Individual;inhibitor;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Kidney;Liver;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic;Metabolic Clearance Rate;Mission;multidisciplinary;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Participant;Pb clearance;Peripheral;Personal Satisfaction;Persons;Physicians;Placebo Control;Placebos;Population;Positioning Attribute;Principal Investigator;Public Health;Quality of life;Research;research and development;Research Technics;Research Training;risk mitigation;Scientist;Skeletal Muscle;skill acquisition;Sodium;stable isotope;subcutaneous;success;symporter;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Tracer;Training;treatment duration;Work

PROJECT_TITLE: Reducing Hyperinsulinemia and Insulin Resistance in Type 1 Diabetes Using Adjunctive Therapies


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Diagnostic errors are a leading cause of morbidity and mortality for patients who are cared for in the emergency department (ED); however, EDs do not routinely learn whether errors occurred, especially among patients who are discharged without inpatient admission. This prospective cohort study will recruit discharged ED patients who are high risk for experiencing errors and harms, and multiple data sources will be used to detect and characterize diagnostic errors, outcomes due to errors, and factors contributing to error. The proposed research project will inform and motivate future systematic inquiry into diagnostic error detection, and the career development award will launch the recipient’s career as an expert in solving problems with the quality and safety of emergency care.

PI_NAMEs: BERDAHL, CARL THOMAS (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Detecting and characterizing diagnostic errors among high-risk patients discharged from the emergency department

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative This proposal outlines an approach to advance our understanding of how cells that support normal blood formation are changed in patients with a hematologic disease called myeloproliferative neoplasms. We will test the hypothesis that changes in interactions between cells in the bone marrow microenvironment cause low blood counts and enlarged spleen size through tumor necrosis factor-alpha (TNF-?) and platelet derived growth factor (PDGF). This preclinical research may lead to new combinations of therapies for clinical trials in patients with myeloproliferative neoplasms to prevent development and worsening of disease.

PI_NAMEs: OETJEN, KAROLYN ANN (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute leukemia;Blood;blood formation;bone;Bone Marrow;Bone Marrow Involvement;Bone Marrow Transplantation;candidate identification;career development;Cell Maturation;Cell Surface Receptors;Cells;Chronic;Clinical;Clonal Expansion;Collaborations;Collagen;Collagen Fiber;Cytokine Signaling;Data;Deposition;Development;Disease;Disease Progression;effective intervention;effective therapy;Environment;Extramedullary Hematopoiesis;Fibrosis;Genetic;genetic signature;Genetic Transcription;Goals;Grant;grasp;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;Human;improved;improved outcome;In Vitro;in vivo;Individual;inducible Cre;Inflammation;Inflammatory;innovation;insight;Laboratory Research;Laboratory Study;LEPR gene;Link;Malignant - descriptor;Marrow;Megakaryocytes;Mentors;Minerals;Modeling;monocyte;mouse model;multiplexed imaging;Mus;Mutation;Myelofibrosis;Myeloproliferative disease;new combination therapies;Organ;Osteosclerosis;Pathogenesis;Patient-Focused Outcomes;Patients;PDGFRA gene;PDGFRB gene;pharmacologic;Platelet Count measurement;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;Play;Population;pre-clinical research;prevent;Production;Protein Secretion;receptor;Receptor Signaling;Receptors, Tumor Necrosis Factor, Type II;Red Blood Cell Count;Reporting;Risk;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Source;Splenomegaly;Stains;stem cell biology;Stem Cell Factor;Stromal Cell-Derived Factor 1;Stromal Cells;Supporting Cell;Testing;therapeutic target;Therapy Clinical Trials;TNF gene;TNFRSF1A gene;TNFRSF1B gene;Training;Transforming Growth Factors;Transgenes;transplant model;Transplantation;tumor progression;Universities;Washington

PROJECT_TITLE: Myelofibrosis impacts the hematopoietic niche through TNF-a


NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: The ability to regulate and efficiently use energy is required for neuron signaling within the brain. The neuron targets mitochondria to areas of high energy need through the use of motor proteins, some of which are bound by general anesthetics. This project seeks to define the consequence of that binding on alterations in mitochondrial density within subcellar regions of the neuron and on changes in behavioral responses.

PI_NAMEs: BEDELL, VICTORIA MARIE (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Actins;Adrenergic alpha-Agonists;Affect;Anesthesia procedures;Anesthetics;anterograde transport;Area;Axon;behavior test;Behavioral;behavioral phenotyping;behavioral response;Binding;Binding Proteins;Biological Assay;Biology;Brain;Cell Culture Techniques;Cell Nucleus;Cell Physiology;Cells;Complex;Data;density;Development;Dissociation;Dynein ATPase;Energy consumption;Ensure;Etomidate;Event;Exposure to;Extramural Activities;Face;Fishes;General anesthetic drugs;Goals;Homeostasis;Human;in vivo;in vivo Model;Kinesin;Knock-out;Larva;Link;Location;Measurement;Mentors;Methodology;Microscopy;Mitochondria;Mitochondrial Proteins;model organism;Modeling;Motion;Motor;Movement;Mutation;neural network;Neurobiology;Neurons;neurotransmission;Nuclear;Oxidative Phosphorylation;Pathway interactions;pharmacologic;Propofol;protein complex;protein transport;Proteins;Research Personnel;Resistance;Resolution;response;retrograde transport;sevoflurane;Signal Transduction;skills;Stains;statistics;Synapses;Synaptic Transmission;Synaptic Vesicles;System;Time;Unconscious State;vesicular release;Whole Organism;Work;Writing;Zebrafish

PROJECT_TITLE: Effects of general anesthetics on mitochondrial cellular distribution


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

ORG_CITY: PISCATAWAY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Bone regeneration can be facilitated with growth factor BMP-2 if provided at consistent optimal dosing. Unfortunately, current drug release approaches result in supraphysiological dosing of BMP-2 which leads to negative side effects. Here, we plan to fine tune BMP-2 solubility in polymer matrices using complex copolymers, robotics, and artificial intelligence.

PI_NAMEs: GORMLEY, ADAM JOSEPH (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Address;Adsorption;amphiphilicity;aqueous;Artificial Intelligence;Behavior;Benchmarking;biodegradable polymer;Biological;Biological Products;Biomedical Engineering;bone growth factor;Bone Morphogenetic Proteins;Bone Regeneration;Characteristics;Complex;Confocal Microscopy;copolymer;Data;Deposition;design;design,build,test;Dose;Drug Delivery Systems;drug distribution;drug release kinetics;Emulsions;Encapsulated;Endowment;Environment;Esters;Formulation;Generations;Goals;hybrid protein;Hybrids;Hydrogels;Hydrophobicity;Label;Lead;Learning;Machine Learning;machine learning model;Methods;Methylene Chloride;Modeling;Organic solvent product;osteogenic;particle;performance tests;Pharmaceutical Preparations;Phase;Polymer Chemistry;Polymers;Process;professor;Protein Denaturation;Proteins;Robotics;side effect;small molecule;Solubility;Solvents;Surface;System;Techniques;technology platform;Testing;Training;tyrosol;Universities;Visualization;Water;Work

PROJECT_TITLE: Biologic Encapsulation by Tuning their Organic Solubility with Amphiphilic Polymers

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative The extension of lifespan that is disease-free and cognitively lucid is the most pressing research goal in present- day’s rapidly greying global population. Leveraging a newly discovered diet-drug interaction, this project investigates the role of dietary protein levels in the physiological response to lifespan extension and in the amelioration of cognitive deficits in early and late onset mouse models of Alzheimer’s disease. Long-term benefits of this research program will clarify how the variables governing the metabolic state, such as our protein intake, can be manipulated to optimize our biological predisposition for a long and healthy life.

PI_NAMEs: YEH, CHUNG-YANG  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Ablation;Address;Adipocytes;Adipose tissue;Adult;Age;Age-associated memory impairment;aged;Aging;aging biomarker;aging population;aging process;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Animals;Autophagocytosis;Binding;Biological;Biology of Aging;Body Composition;Brain;Cognitive;Cognitive deficits;cognitive performance;cohort;Data;Dedications;detection of nutrient;Development;Diet;dietary;Dietary Intervention;dietary manipulation;Dietary Proteins;dietary restriction;Disease;Disease Progression;Drug Interactions;early onset;Elements;Energy Metabolism;Essential Amino Acids;Evaluation;extend lifespan;Female;FRAP1 gene;Functional disorder;Genetic;geroprotector;Geroscience;glucose tolerance;Goals;Health;healthspan;healthy aging;human old age (65+);hyperphosphorylated tau;Impaired cognition;improved;Inflammation;inflammatory marker;innovation;insight;Investigation;Isoleucine;Knock-in Mouse;Knowledge;Late Onset Alzheimer Disease;Life;life span;Lipase;lipid biosynthesis;lipidomics;Lipids;Lipolysis;Liver;Longevity;male;Mediator;Metabolic;metabolic phenotype;Metabolic syndrome;Metabolism;Methionine;Methods;Modeling;Molecular;Molecular Analysis;mouse model;Mus;neuropathology;Nutrient;Pathogenesis;Pathway interactions;Peripheral;Pharmaceutical Preparations;Physiological;Physiology;Play;Population;Predisposition;prevent;Productivity;programs;protein intake;Proteins;Publications;Regulation;Reporting;Research;Research Personnel;response;Role;senescence;sensor;Serum;Signal Transduction;Sirolimus;Symptoms;Thermogenesis;Tissues;Training Programs;Transgenic Mice

PROJECT_TITLE: Investigating the Mechanistic Role of Dietary Protein in Aging and in Alzheimer's Disease

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Head and Spine Injury

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Each year in the United States, approximately 18,000 patients will experience a spinal cord injury leading to the irreversible loss of sensory and motor function. To identify pro-regenerative immune pathways, this proposal utilizes the spontaneously regenerating adult zebrafish spinal cord and the zebrafish immune system that is evolutionarily conserved with mammals. The pro-regenerative genes and pathways identified here will provide candidates for novel therapies for patients suffering from the devastating effects of spinal cord injury.

PI_NAMEs: SHAW, DANA NICOLE (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Ablation;Adult;Amaze;Anatomy;Automobile Driving;Axon;Behavior;Biological Models;Blood;Cell Culture System;Cell Physiology;Cells;Circulation;Communities;Complex;Data;design;Environment;Event;Excision;Exhibits;experience;experimental study;functional outcomes;Future;Gene Expression;gene function;Genes;Genetic;Genetic Transcription;Goals;Growth;healing;Health;Human;human induced pluripotent stem cells;human tissue;Image;Immune;immune activation;Immune response;Immune system;immunoregulation;improved;Infiltration;injured;Injury;injury recovery;Laboratories;Lesion;Leukocytes;loss of function;Macrophage;Mammals;Measures;medical schools;Microglia;Molecular;Motor;Mus;mutant;Myelin;Natural regeneration;nerve injury;neuroimmunology;novel;novel therapeutics;Outcome;overexpression;Pathway interactions;Patients;permissiveness;Phagocytes;Phagocytosis;Phase;Positioning Attribute;prevent;Process;Protocols documentation;Recovery of Function;regeneration function;regenerative;Regenerative capacity;Regenerative pathway;research faculty;response;Role;self-renewal;Sensory;Site;Spinal Cord;Spinal cord injury;Spinal cord injury patients;spinal cord regeneration;System;Techniques;tenure track;Testing;tissue repair;Tissues;tool;Training;United States;Universities;Visualization;Washington;Work;wound closure;wound healing;Zebrafish

PROJECT_TITLE: Immune regulation of spinal cord regeneration

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Lung;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite decades of research, there are no specific, targeted pharmacotherapies for the Acute Respiratory Distress Syndrome (ARDS), a common and deadly problem in critically ill patients. We propose a mechanism where host transfer RNAs (tRNAs) modulate host defense in experimental lung injury and explore regulation of tRNAs and tRNA fragments by the tRNA methyltransferase, TRMT1. tRNA fragments are unexplored in ARDS pathobiology and may represent novel therapeutic targets.

PI_NAMEs: BEDNASH, JOSEPH STANLEY (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Advisory Committees;Award;Bacterial Infections;Bioinformatics;Biological;Biological Markers;Biological Process;Biology;career;career development;Cell Death;Cell model;Cell Physiology;Cells;Cellular Stress;Cessation of life;Clinical;Cognitive;Complex;Critical Care;Critical Illness;Data;Diffuse;Disease;Endotoxins;Ensure;Environment;experience;Experimental Models;Family;Foundations;Funding;Future;Genetic Transcription;Guanine;health care service utilization;Heart Diseases;Host Defense;Host Defense Mechanism;Host resistance;Human;human disease;Immunology;immunopathology;immunoregulation;In Vitro;Individual;Infection;Inflammasome;Inflammatory;inflammatory lung disease;inhibitor;Injury;insight;K-Series Research Career Programs;Knockout Mice;Liquid substance;Lung;lung injury;Macrophage;Mediator;Medicine;Mentors;Mentorship;Messenger RNA;Metabolic stress;Methylation;Methyltransferase;microbial;MicroRNAs;Modeling;Modification;Molecular and Cellular Biology;mouse model;Myelogenous;new therapeutic target;novel;novel strategies;Ohio;Oxidative Stress;Parents;pathogen;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Physicians;Physiological;Pneumonia;posttranscriptional;preservation;prevent;Principal Investigator;professor;programs;Proteins;Pseudomonas aeruginosa;psychologic;Pulmonary Fibrosis;Pulmonary Inflammation;Quality of life;Regulation;Research;respiratory;RNA;RNA Stability;Role;Sampling;Scientist;Signaling Molecule;skills;Sleep;Source;Specificity;Stress;stressor;success;Survivors;Syndrome;Testing;tissue injury;Tissues;Training;transcriptome;transcriptome sequencing;Transfer RNA;translational physician;translational progress;translational study;Translations;tRNA Methyltransferases;Universities;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Transfer RNAs as novel mediators in acute lung injury

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Prevention;Primary Health Care;Social Determinants of Health;Vaccine Related

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Despite the importance of seasonal vaccination for preventing infections, hospitalizations, and deaths, COVID- 19 and influenza vaccination rates among children lag significantly behind coverage rates for non-seasonal, childhood vaccines, including hepatitis B, measles, mumps, rubella, polio, and varicella. As such, the determinants of parental hesitancy for seasonal respiratory vaccines may fundamentally differ from those for non-seasonal, childhood vaccines, which has significant public health implications for the development of interventions for addressing parental vaccine hesitancy in the post-pandemic era. The proposed project will identify the factors influencing parental hesitancy for seasonal respiratory vaccines, identify pediatricians’ perceived challenges and facilitators of vaccine communication, and develop and evaluate a targeted communication strategies pilot that may help to improve seasonal respiratory vaccine uptake among children.

PI_NAMEs: SCHAFFER DEROO, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: 2019-nCoV;Address;Age;Area;Awareness;Behavior Therapy;Behavioral Sciences;burnout;career;Caregivers;Cessation of life;Chickenpox;Chickenpox Vaccine;Child;Child Health;Childhood;Clinical;Clinical effectiveness;clinical practice;cohort;Communication;Communication Tools;Communities;COVID-19;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Data;Decision Making;design;Development;Dose;Educational Curriculum;effectiveness outcome;Endemic Diseases;evidence base;Evidence based intervention;experience;Family;Focus Groups;Funding;Future;Goals;health communication;Hepatitis B;Hospitalization;implementation measures;implementation science;implementation/effectiveness;improved;Infection prevention;Influenza;Influenza vaccination;influenza virus vaccine;Intervention;Interview;Leadership;Measles;Measles-Mumps-Rubella Vaccine;Methods;motivational enhancement therapy;Multicenter Studies;Mumps;novel;novel strategies;novel vaccines;Online Systems;pandemic disease;parental influence;parenting intervention;Parents;pediatric patients;pediatrician;Physicians;Pilot Projects;Poliomyelitis;Poliovirus Vaccines;post-COVID-19;post-pandemic;pre-pandemic;preference;Process;Public Health;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Personnel;respiratory;respiratory virus;response;Risk;Rubella;Sampling;seasonal influenza;Seasons;Severity of illness;skill acquisition;Structure;Surveys;Techniques;therapy development;Training;Translating;transmission process;trend;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;Vaccines;Washington

PROJECT_TITLE: Caregiver decision making for seasonal respiratory vaccines for children


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This K24 renewal builds upon the patient-oriented research on viral gastroenteritis by the candidate, Sylvia Becker-Dreps, MD, MPH. In this application, she proposes to acquire new research skills to investigate factors that protect against norovirus gastroenteritis in young children, including maternal antibodies, bioactive components of breastmilk, and the infant gut microbiome composition, to identify future interventions. Early- career clinical investigators will be integrated into her work through the use of existing data and biobanked samples for independent research projects under her mentorship, and can take advantage of the rich opportunities for research skills development at the University of North Carolina at Chapel Hill, including from the Office of Global Health Education, where Dr. Becker-Dreps has a new leadership role.

PI_NAMEs: BECKER-DREPS, SYLVIA IRENE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Accounting;Antibodies;Bacteria;biobank;Biological Assay;Birth;Blood Group Antigens;Breast Feeding;Breastfed infant;burden of illness;career;career development;Characteristics;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;cohort;Cohort Studies;Communicable Diseases;Complement;Complex;Data;Development;early childhood;enteric infection;Epidemiology;Epithelial Cells;Family Practice;Feces;Funding;Future;Gastroenteritis;Genotype;global health;Glycobiology;Goals;gut microbiome;gut microbiota;Health education;High Pressure Liquid Chromatography;Human;Human Milk;human milk oligosaccharides;Immune;Immunity;Individual;Infant;infant gut microbiome;Infection;interdisciplinary approach;Intervention;intestinal epithelium;Laboratories;Lactation;Leadership;Learning;Life;Maternal antibody;maternal serum;Measures;Mentors;Mentorship;Methods;microbiome composition;Mid-Career Clinical Scientist Award (K24);Mothers;Natural History;next generation;Nicaraguan;Norovirus;North Carolina;Oligosaccharides;Ownership;pathogen;patient oriented research;Performance;Physicians;Placenta;Play;Predisposing Factor;Predisposition;prevent;Prevention;receptor;Research;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk;Risk Factors;Role;Rotavirus Vaccines;Sampling;Sapovirus;Science;Scientist;Serum;Shapes;skill acquisition;skills;Time;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;vaccine development;Viral Gastroenteritis;Weaning;Woman;Work

PROJECT_TITLE: Understanding protection against norovirus at the maternal-child interface

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Infectious Diseases;Prevention;Primary Health Care

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE In low- and middle-income countries (LMICs), there is a need to identify and test community led strategies that address the burden of non-communicable disease (NCD) among people living with HIV (PLWH). Use of community-clinical linkages is effective for managing and treating NCD management, including hypertension, HIV, high cholesterol, and diabetes in LMICs. The proposed study will collaborate with community stakeholders to co-develop a community-clinical linkage strategy to link PLWH and comorbid hypertension to clinic care, and then assess the acceptability, appropriateness, and feasibility of the community-led strategy.

PI_NAMEs: AIFAH, ANGELA  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acceleration;Address;Administrator;Cardiovascular Diseases;career development;Caring;Cholesterol;Chronic Disease;Clinic;Clinical;clinical care;Clinical effectiveness;Clinical Treatment;Collaborations;Communities;community clinical linkage;community collaboration;community engaged approach;community engaged research;community engagement;community organizations;community partners;comorbidity;Complex;COVID-19 pandemic;Data;design;Diabetes Mellitus;Disease;Disease Management;disease model;disorder prevention;dynamic system;Educational workshop;effectiveness evaluation;Emerging infection;Evidence based practice;Focus Groups;Funding;Future;Goals;Group Meetings;Health;Health Personnel;Health system;HIV;HIV/AIDS;human centered design;Hypertension;hypertension control;hypertension treatment;implementation research;implementation science;implementation strategy;Improve Access;Individual;Infrastructure;innovation;integrated care;Knowledge;Life Expectancy;Link;low and middle-income countries;Maps;Mentors;Methods;Modeling;Muslim religion;National Heart, Lung, and Blood Institute;Needs Assessment;Nigeria;opioid use disorder;Parents;Participant;Patients;Persons;Phase;Pilot Projects;Politics;primary health center;programs;Public Health;Research;Research Design;research study;Role;satisfaction;Science;Services;skills;social health determinants;Support Groups;System;Testing;theories;Training;Translating;Translational Research;Underserved Population;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: LeveRaging Community Engagement to SusTAIN NCD InTegrated Care Models (RETAIN-IT)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Apply Machine learning will expedite synthetic chemistry enterprise, which in turn will facilitate the discovery of untapped chemical space access, leading to new bioactive structures. This project will also enhance sustainability by promoting first-row transition metal catalysts like nickel (Ni), develop new asymmetric methods using radical based methods, and waste and resource minimization. Overall, it will a new paradigm in chemical synthesis that could have a profound impact both on biomedical science and human health.

PI_NAMEs: MAJI, RAJAT  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Acceleration;Active Learning;Adopted;Adoption;Agrochemicals;Alkaloids;Architecture;Artificial Intelligence;Automobile Driving;Biomedical Research;career;career development;Case Study;Catalysis;catalyst;chemical reaction;chemical synthesis;Chemicals;Chemistry;Collaborations;Computational algorithm;Coupling;Data;data platform;Data Science;Data Set;Descriptor;design;Development;Discipline;Esterification;Exercise;experience;experimental study;Feedback;Fellowship;Funding;Generations;Goals;Grant;Health;heuristics;Human;Image;improved;Industry;Industry Collaboration;innovation;insight;Knowledge;Laboratories;Learning;Libraries;Link;Machine Learning;machine learning algorithm;Medicine;Mentored Clinical Scientist Development Award (K08);Mentors;Mentorship;Methodology;Methods;Molecular;National Institute of General Medical Sciences;Nickel;Organic Chemistry;Organic Synthesis;Outcome;Pharmaceutical Chemistry;Phase;Play;Preparation;Process;process optimization;programs;Protocols documentation;Psychological reinforcement;Rationalization;Reaction;real world application;Recommendation;Reproducibility;Research;Research Personnel;Resources;Role;Sampling;Science;screening;Securinega;skills;speech recognition;Strategic Planning;Structure;supervised learning;Synthesis Chemistry;System;Technology;Time;tool;Training;Transition Elements;United States National Institutes of Health;wasting

PROJECT_TITLE: Data to Design: An Integrated Approach to Developing New Synthetic Methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (KR)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The standard clinical diagnosis approach and existing studies show limited performance in predicting clinically significant prostate cancer. This project aims to develop diagnosis and prognosis tools that will have a positive impact on successful treatment planning and clinical management. The proposed project will utilize sophisticated machine learning and deep learning techniques for robust prostate and zonal segmentation, accurate prediction of a cancer probability map, and interpretable biochemical recurrence prognosis using multimodal data.

PI_NAMEs: KIM, HEEJONG  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: accurate diagnosis;Adopted;Affect;American;Anatomy;Architecture;Award;Biochemical;Biology;Biopsy;Blood Tests;Cancer Biology;cancer diagnosis;Cancer Etiology;cancer imaging;cancer site;Cessation of life;Clinical;clinical diagnosis;Clinical Management;clinical predictors;clinically significant;Complement;Computing Methodologies;Counseling;Data;Data Set;deep learning;deep learning model;density;Detection;Development;Diagnosis;diagnosis standard;Digital Rectal Examination;Ethnic Origin;Evaluation;experience;Family;Future;Genomics;Image;Image Analysis;imaging Segmentation;improved;Information Systems;Knowledge;Label;large-scale imaging data;Learning;Lesion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Masks;Medical;Medicine;men;Mentorship;Methods;Modality;Modeling;multidisciplinary;multimodal data;multimodal learning;multimodality;multiparametric imaging;neural;neuroimaging;Nomograms;novel;Oncology;Outcome;Pathology;Patients;Performance;Prediction of Response to Therapy;predictive modeling;Probability;Prognosis;programs;Prostate;Prostate-Specific Antigen;Protocols documentation;PSA level;Quality Control;Race;Radical Prostatectomy;radiologist;radiomics;Recording of previous events;Recurrence;Reporting;Research;research clinical testing;Research Personnel;risk stratification;Science;screening;Selection for Treatments;serum PSA;Severities;Site;skills;Staging;Structure of base of prostate;targeted imaging;Techniques;Test Result;The Cancer Imaging Archive;tool;Training;Treatment outcome;treatment planning;Vendor

PROJECT_TITLE: Robust and Interpretable Multimodal Machine Learning Models for Diagnosis and Prognosis of Prostate Cancer

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unpredictable disease course that affects 1 in 200 older adults over 65 years old. Some, but not all, IPF patients have identifiable factors that lead to a worse prognosis. This study will systematically assess genetic mutations and their consequences in the lung of IPF patients which may lead to precision therapies for specific disease pathways in subtypes of IPF.

PI_NAMEs: ZHANG, DA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Affect;ATAC-seq;biobank;Candidate Disease Gene;career;career development;Categories;Cell Nucleus;cell type;Cells;Characteristics;Cicatrix;Clinical;clinical care;clinically relevant;cohort;Coupled;Cryopreservation;Data;Data Set;Diagnosis;Disease;Disease Pathway;DNA Sequence Alteration;Epigenetic Process;epigenomics;follow-up;functional genomics;Funding;Future;Gene Expression;Genes;Genetic;genetic association;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome sequencing;genome wide association study;Genomics;Genotype-Tissue Expression Project;Goals;Heritability;Human Genetics;human old age (65+);idiopathic pulmonary fibrosis;Immunosuppression;Individual;innovation;K-Series Research Career Programs;Knowledge;Length;Lung;Maps;Mentors;Mentorship;Meta-Analysis;Methods;molecular sequence database;mortality;multidisciplinary;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;National Institute of General Medical Sciences;novel;Nuclear RNA;older adult;Outcome;Pathogenesis;Pathway interactions;Patients;phenome;Precision therapeutics;Prevention;Prognosis;programs;prospective;Publications;Pulmonary Fibrosis;Rare Diseases;rare variant;Regulatory Element;Research;research data dissemination;Research Personnel;Research Training;Risk;Risk Factors;risk variant;Seminal;skills;Structure;Structure of parenchyma of lung;telomere;telomere damage;Testing;Tissue Donors;Tissues;Training;Training Activity;Trans-Omics for Precision Medicine;transcription factor;transcriptome sequencing;transcriptomics;translational research program;translational study;Validation;Variant;whole genome;Work

PROJECT_TITLE: Multi-omic profiling of IPF endotypes


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The artemisinin family of drugs are the most effective frontline class of drugs used to treat infections with Plasmodium falciparum, the deadliest malaria-causing parasite in humans, yet the emergence of artemisinin resistance threatens disease eradication efforts. Our understanding of the molecular mechanisms implicated in artemisinin resistance remains incomplete. This project investigates how RNA-binding proteins, important post- transcriptional regulators of gene expression, support artemisinin resistance in P. falciparum.

PI_NAMEs: RUBERTO, ANTHONY A (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Artemisinins;Award;Biological;biological adaptation to stress;Biological Assay;Biology;career;Cell Survival;Cells;Cessation of life;chromosome conformation capture;Clinical;Combined Modality Therapy;Communicable Diseases;Competence;Complex;conditional mutant;CRISPR/Cas technology;crosslink;Data;Dedications;Digestion;Disease;Drug Exposure;Drug resistance;Drug usage;Event;Evolution;Falciparum Malaria;Family;fitness;functional genomics;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;genetic signature;Genetic Variation;Genome;Genomics;Goals;Growth;Hemoglobin;Hi-C;High-Throughput Nucleotide Sequencing;Human;Immunoprecipitation;In Vitro;Infection;insight;knock-down;Knowledge;knowledge base;Life;Link;Malaria;Mediating;Mentors;Messenger RNA;Methods;Molecular;molecular marker;Multi-Drug Resistance;mutant;Mutation;novel therapeutic intervention;Outcome;Outcome Study;Parasite resistance;Parasites;Parasitic infection;Pathologic Processes;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasmids;Plasmodium;Plasmodium falciparum;Play;Post-Transcriptional Regulation;posttranscriptional;Proteins;Public Health;Regulator Genes;Research;Research Personnel;Resistance;resistance mechanism;resistome;Resolution;Risk;RNA;RNA-Binding Proteins;Role;Scientist;single-cell RNA sequencing;skills;Supporting Cell;Techniques;Time;tool;Transcriptional Regulation;transcriptomics;Translational Repression;Translations;Up-Regulation;Work

PROJECT_TITLE: State of the ART: Functional genomics of RNA-binding proteins and their role in artemisinin drug resistance in Plasmodium falciparum