ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Telehealth;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Gay, bisexual, and other men who have sex with men (MSM) in the United States shoulder a disproportionate burden of HIV, trauma exposure (especially interpersonal violence that is often motived by prejudice), and associated PTSD and substance use, which may negatively impact uptake of HIV pre-exposure prophylaxis (PrEP), an effective HIV-preventive biomedical intervention. Latent class mediation analysis can identify the extent to which distinct and unique patterns of PTSD symptomology and substance use mediate the effect of prejudice-motivated violence on PrEP uptake in this population, and in conjunction with qualitative findings from local violence-exposed MSM and key community stakeholders can inform a novel trauma-informed mHealth + peer support intervention to support PrEP uptake, contributing to a reduction in HIV transmission and related disparities. Through this K01, Dr. Wiginton will leverage the UCSD training infrastructure to build his professional research independence for improving PrEP uptake among marginalized populations through innovative trauma-informed approaches, positioning him as a leader in the next generation of queer scholars to contribute toward ending the HIV epidemic among racially/ethnically diverse MSM in the United States.

PI_NAMEs: WIGINTON, JOHN MARK (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Adherence;Affect;AIDS prevention;Area;Award;Awareness;Behavior;behavior change;Behavior Therapy;biopsychosocial;Bisexual;bullying;California;Cellular Phone;Characteristics;Child Abuse;cis-female;Clinical;Collaborations;Communities;community engaged research;community violence;Competence;coping;Coupled;Cross-Sectional Studies;Data;design;Development;Disparity;early phase clinical trial;Eligibility Determination;empowerment;Enrollment;Environmental Risk Factor;Epidemic;ethnic diversity;evidence base;experience;female sex worker;Fostering;Future;Gays;Gender;Goals;healing;Health;Health behavior;HIV;HIV disparities;HIV/AIDS;human centered design;improved;Individual;innovation;insight;Interpersonal Violence;Intervention;Knowledge;life span;marginalization;marginalized population;Mediating;Mediation;Mediator;men of color;men who have sex with men;Methods;mHealth;mhealth interventions;mobile application;next generation;nonbinary;novel;Outcome;Pathway interactions;Pattern;peer;peer coaching;peer support;Personal Satisfaction;Persons;Population;Positioning Attribute;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prejudice;Prevalence;Preventive;preventive intervention;psychosocial wellbeing;queer;Race;racial diversity;Reporting;Research;resilience;resilience factor;response;Risk;Safety;Sampling;Self Efficacy;service delivery;Services;Sexual and Gender Minorities;Sexual Health;sexual minority health;Shoulder;skill acquisition;skills;social stigma;social structure;Social support;structural health determinants;substance use;Symptoms;syndemic;Target Populations;Technology;Testing;tool;Training;Training and Infrastructure;transgender women;transmission process;Trauma;trauma exposure;traumatic event;Trust;United States;uptake;usability;Violence;violence exposure

PROJECT_TITLE: BOUNCE: Development of a trauma-informed mHealth + peer support intervention to promote PrEP uptake among men who have sex with men

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Malaria is caused by parasites of the genus Plasmodium and over one billion people are at risk of infection every year. Unfortunately, the rapid development of resistance to all current antimalarials highlights the urgent need to develop new drugs with different mode of actions to overcome this pressing problem. This work aims to optimize two novel, inexpensive and effective classes of antimalarials that target multiple life stages of the parasite. In addition, the proposed studies to uncover how these antimalarials work will reveal valuable information to define unknown cellular (on and off) targets in malaria parasite that in turn will aid the development of safer treatments to circumvent drug resistant malaria in the campaign for disease eradication.

PI_NAMEs: CARLIER, PAUL R (contact);CASSERA, MARIA BELEN

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adsorption;Affect;analog;Anti-malarials;Applications Grants;Artemisinins;asexual;Azides;Benzofurans;Biological Assay;Biological Availability;Blood;Cessation of life;Chemicals;Chemistry;chemoproteomics;chemotherapeutic agent;Chloroquine;Clinical;Complement;Consensus;Contracts;Copper;Development;Diazomethane;Disease;Dose;drug candidate;Drug Kinetics;Drug resistance;Escherichia coli;Evolution;Excretory function;experimental study;Funding;genome sequencing;Goals;Growth;Human;improved;In Vitro;in vivo;Infection;infection risk;Lead;lead optimization;Libraries;Life;Ligands;Liver;Malaria;malaria infection;Mammalian Cell;Medical;Metabolism;meter;Modification;Molecular Target;mouse model;Mus;novel;novel therapeutics;Oral;Oral Administration;Parasite resistance;Parasites;pathogen;Pharmaceutical Preparations;pharmacophore;Phenotype;photolysis;Plasma;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Population;Populations at Risk;Positioning Attribute;pre-clinical;preclinical development;prevent;Probability;Property;Proteins;Proteomics;Rattus;Recrudescences;Resistance;Resistance development;resistance mechanism;Risk;scaffold;screening;Series;Solubility;Structure;Structure-Activity Relationship;Synthesis Chemistry;timeline;Toxic effect;Triage;United States National Institutes of Health;virtual;whole genome;Work

PROJECT_TITLE: Optimization of antimalarials targeting multiple life stages of the parasite

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In South Africa, migrant men are at elevated risk of acquiring HIV, and pre-exposure prophylaxis (PrEP) is effective at preventing HIV, but migrant men face barriers to using PrEP, including lack of knowledge and counseling, the opportunity costs of seeking care, and unfamiliarity with health services in a new setting. Pilot data show that migrant men are interested in using PrEP should they be given information and counseling, and if other barriers are addressed, including lost work opportunities as well as the inconveniences and perceived stigma at clinics. This study will 1) elicit preferences for PrEP counseling and service delivery among migrant men through qualitative interviews and a DCE; 2) design a “Healthy Welcome” intervention for migrant men to promote linkage to community pharmacies for PrEP uptake and adherence; and 3) evaluate the feasibility, acceptability, appropriateness, and fidelity of the intervention through a pilot RCT.

PI_NAMEs: NARDELL, MARIA FRANCESCA (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;Adherence;African;AIDS prevention;Area;arm;Award;Awareness;Behavioral;behavioral economics;Behavioral Model;building materials;care seeking;career development;Caring;Clinic;Clinical Trials;Collaborations;Communities;community engagement;Community Health Aides;Community Pharmacy;contextual factors;Counseling;Data;design;Development;Diphosphates;Effectiveness of Interventions;efficacy evaluation;Eligibility Determination;Ensure;evidence base;experience;Experimental Designs;experimental study;Face;Feedback;field study;Focus Groups;follow-up;Funding;Goals;Grant;Health;Health Resources;Health Services;high risk;HIV;homeless shelters;Hospitals;Human immunodeficiency virus test;implementation outcomes;implementation science;improved;Incentives;Incidence;Inequality;Infrastructure;interest;Internal Medicine;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Knowledge;Link;Measurement;medical schools;member;men;Mentors;Mentorship;Methodology;Methods;mHealth;Migrant;migration;Modeling;opportunity cost;Participant;Patient Self-Report;Pharmacists;Pharmacy facility;Phase;Physicians;pilot test;pilot trial;policy implication;Population;pre-exposure prophylaxis;preference;prevent;Prevention;preventive intervention;primary outcome;Process Assessment;Proctor framework;Provider;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Risk;Sampling;Scientist;secondary outcome;service delivery;Services;Site;skills;social;social norm;Social Processes;social stigma;South Africa;Southern Africa;standard of care;Structure;success;Surveys;Tenofovir;Testing;Text;theories;therapy development;Training;United States National Institutes of Health;uptake;voucher;Woman;Work

PROJECT_TITLE: Development and Pilot RCT of a "Healthy Welcome" Intervention to Increase PrEP Uptake and Adherence Among Migrant Men in Johannesburg

STUDY_SECTION: HIBI


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Uromodulin-associated chronic kidney disease (CKD), a significantly underestimated disease in Veterans, causes renal fibrosis and progressive renal failure. There is no mechanism-based treatment. The goal of this project is to develop novel therapeutics, which can restore mitochondrial homeostasis and mitigate mitochondrial damage-mediated inflammation, to treat uromodulin-associated CKD or other forms of CKD induced by organelle stress in Veterans.

PI_NAMEs: CHEN, YING MAGGIE (contact)

PROJECT_TERMS: Acceleration;Address;Adult;American;Apoptosis;Astrocytes;autosome;Biogenesis;Biological Response Modifier Therapy;Biology;causal variant;Cell Death;Cell model;Cells;cellular imaging;Chronic Kidney Failure;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;CRISPR/Cas technology;Data;Deletion Mutation;Dependovirus;Diabetic Nephropathy;Disease;Disease Progression;endoplasmic reticulum stress;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Extravasation;Fibrosis;Frequencies;Gene Activation;Gene Deletion;General Population;genetic variant;Goals;Health;Homeostasis;Human;Hyperactivity;hypertensive;imaging detection;Immune;Impairment;improved;In Situ;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;injured;Injury;innovation;innovative technologies;insight;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;kidney fibrosis;Knockout Mice;Lead;Legal patent;Limb structure;LoxP-flanked allele;Macrophage;Mediating;Medical;metagenome;Mitochondria;Mitochondrial DNA;mitochondrial therapeutics;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neighborhoods;Nerve Growth Factor Receptors;neurotrophic factor;novel;novel therapeutic intervention;novel therapeutics;Onset of illness;Organelles;overexpression;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathway interactions;Patients;PET/CT scan;Population;Positioning Attribute;preservation;Prevalence;programs;Proteins;Quality Control;Reactive Oxygen Species;Regulation;Renal function;Research;Research Personnel;Role;Serum;Signal Transduction;single-cell RNA sequencing;Stimulator of Interferon Genes;Stress;Structure of ascending limb of Henle's loop;targeted treatment;Testing;Therapeutic;Thick;tool;transcriptomics;Transgenic Mice;translational potential;Tubular formation;UMOD gene;Validation;Variant;Veterans

PROJECT_TITLE: Therapeutic Targeting of Mitochondria in Uromodulin-Associated Chronic Kidney Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Richmond

ORG_NAME: BIOXYTECH RETINA, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Diabetes and diabetic retinopathy (DR) impact millions of Americans, especially minorities and medically underserved communities. This project leverages a first-of-its-kind, clinically validated technology that, combined with machine and deep learning, allows pre-stage and early-stage DR prediction before the onset of vision loss.

PI_NAMEs: BASIRI, ALI  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: absorption;access disparities;Address;Adoption;Advanced Development;Affect;African American population;Algorithms;American;analog;Artificial Intelligence enhanced;Back;bevacizumab;Black race;Blindness;Caring;Classification;Clinical;Clinical Research;cloud storage;commercialization;comparative;Complication;Complications of Diabetes Mellitus;Computer software;cost;Counseling;Data;data acquisition;Data Analyses;deep learning;Deposition;Detection;Development;Devices;Diabetes Mellitus;Diabetic Retinopathy;Diagnosis;diagnostic accuracy;Diagnostic Imaging;digital;Disease;Early Diagnosis;Early Intervention;Early treatment;effective intervention;Engineering;Evaluation Studies;Eye;Funding;Fundus photography;Health;Health Disparities Research;health disparity;health disparity populations;health equity promotion;High Prevalence;Human;Image;Image Analysis;Imaging Device;imaging system;Imaging technology;improved;in vivo;innovation;Institution;Intervention;Label;Latino;Latino Population;Legal patent;Light;light intensity;Machine Learning;machine learning algorithm;manufacture;mathematical model;Measures;Medical;medically underserved;medically underserved population;Methods;Minority;minority communities;Minority Groups;Monitor;Mydriatics;Native American population;Native Americans;new technology;non-invasive imaging;Not Hispanic or Latino;novel;Optometrist;Outcome;Oxygen;Oxygen saturation measurement;Patient risk;Patients;Penetration;Performance;Persons;Phase;Predisposition;Prevalence;prevent;Primary Care Physician;Privatization;research clinical testing;Resolution;Retina;retinal damage;Retinal Diseases;Risk;risk stratification;rural setting;Saccades;screening;Secure;Sensitivity and Specificity;Site;social;Spatial Frequency Domain Imaging;Specialist;Staging;standard of care;Structure;success;System;Technology;technology development;technology validation;Testing;Time;Tribes;underserved community;United States National Institutes of Health;urban setting;Validation;Vision

PROJECT_TITLE: Addressing Health Disparities through AI-Enhanced Prediction of Diabetic Retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (J1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The proposed research will characterize sex specific differences in intestinal epithelial radiosensitivity. This proposal will also examine the metabolic function as determinant of observed sex specific differences in intestinal radiosensitivity. Small molecule based modulator of this metabolic function will be tested as radiation countermeasure against radiation induced acute gastrointestinal syndrome. Successful completion of this project will lead to the development of this small molecule-based therapy as a new medical countermeasure to treat injuries resulting from a radiation or nuclear accident.

PI_NAMEs: SAHA, SUBHRAJIT  (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Address;Adult;aminoacid biosynthesis;animal old age;animal rule;beta catenin;Biological Assay;Carbohydrates;Cell Compartmentation;Cell Lineage;Cell Proliferation;Cells;Childhood;Citric Acid Cycle;crypt cell;Development;differential expression;Dose;Elderly;Epithelial Cells;Epithelium;Etiology;Exhibits;Exposure to;FDA approved;Female;Filgrastim;Funding;gastrointestinal;Generations;Genes;Genetic;Gonadal Steroid Hormones;gut inflammation;Human;human female;human male;Impairment;Inflammation;inhibitor;Injury;intestinal epithelium;Intestines;irradiation;jejunum;juvenile animal;LGR5 gene;Link;Lipids;male;MAP Kinase Gene;mass casualty;Mediating;medical countermeasure;Metabolic;Mitochondria;mitochondrial metabolism;mitochondrial therapeutics;mouse model;Mucositis;Mucous Membrane;Mus;Natural regeneration;Nuclear;Nuclear Accidents;nuclear countermeasure;Nucleotides;Organoids;oxidation;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;p38 Mitogen Activated Protein Kinase;pharmacologic;Population;preclinical study;Process;Production;programs;Proliferating;Proteins;Pyruvate;pyruvate carrier;Pyruvate Metabolism Pathway;Radiation;Radiation Accidents;radiation countermeasure;Radiation induced damage;radiation mitigation;Radiation Tolerance;Radiation Toxicity;Radiology Specialty;radioresistant;Reactive Oxygen Species;repaired;Reporting;Research;Respiration;response;Role;Schedule;self-renewal;Sepsis;sex;Sex Differences;Signal Transduction;small molecule;standard of care;stem cell expansion;stem cell population;stem cell proliferation;stem cells;Structure;Syndrome;Testing;Tissues;Toxic effect;transcriptome sequencing;United States National Institutes of Health;uptake;Villus;Weather;women versus men

PROJECT_TITLE: Sex specific differences in intestinal radiosensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MR-I (M1)]


FUNDING_MECHANISM: OTHERS

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Platelets are the smallest cells in the blood and important in inflammation and the formation of blood clots. Recent findings suggest that platelets are important in a variety of human conditions independent of their role in clotting. One of these conditions is traumatic brain injury (TBI), a disorder affecting many Veterans which can result in symptoms that persist throughout the lifetime of an individual, severely affecting quality of life. The role of platelets in the long-term consequences of TBI is not well understood. The overall goal of this project is to broaden our understanding of interactions between platelets and blood vessels in TBI and define the contribution of platelets to the long-term repercussions of TBI. This Career Development Application seeks to provide the foundation for the applicant's transition to an independent VA investigator studying TBI with the long-term goal of identifying new treatment options for Veterans suffering from TBI.

PI_NAMEs: COURSON, JUSTIN A (contact)

PROJECT_TERMS: active duty;Acute;Address;Adhesions;Affect;Astrocytes;Behavioral;Biological Markers;Blood;Blood - brain barrier anatomy;Blood coagulation;Blood Platelets;Blood Vessels;blood-brain barrier disruption;Brain Injuries;career;career development;Cell Degranulation;Cells;Cephalic;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Chronic;Chronic Phase;Coagulation Process;Collaborations;Confocal Microscopy;Contralateral;controlled cortical impact;Cortical vasculature;Data;Data Reporting;Dedications;defined contribution;Development;Diffuse;Disease;Distal;Electron Microscopy;endothelial dysfunction;Endothelium;Environment;experience;Extravasation;Fluorescence;Fluorescence Microscopy;Fostering;Foundations;Functional disorder;functional outcomes;Future;Goals;health administration;Health Services;Hemostatic function;Histones;Human;Image;Impairment;improved;Individual;Inflammation;Inflammation Mediators;Inflammatory Response;Injury;innovation;intravital microscopy;Kinetics;Knowledge;Laboratories;Literature;Location;mast cell;Mast Cell Stabilizer;Measures;Mediator;Medical center;Mentors;Mentorship;Microvascular Dysfunction;microvascular pathology;military veteran;Modeling;Molecular;Mus;Nerve Degeneration;neurobehavioral;Neurodegenerative Disorders;Neurologic;neuron loss;Neuronal Plasticity;Neurons;new therapeutic target;novel;novel strategies;Outcome;Pathologic;Pathology;Phase;Physiological;Platelet Activation;Play;postcapillary venule;pre-clinical;prevent;programs;Proteins;Publishing;Quality of life;recruit;Research;Research Personnel;Resolution;response;response to injury;Risk;Role;service member;Services;Site;symptomatology;Symptoms;System;Testing;Texas;Therapeutic;therapeutically effective;Thrombosis;Time;tissue trauma;Tissues;Transgenic Mice;Trauma;Traumatic Brain Injury;United States Department of Veterans Affairs;vascular bed;Vascular Diseases;Vascular Endothelium;venule;Veterans;Veterans Health Administration;Visualization;von Willebrand Factor;Wild Type Mouse;Work

PROJECT_TITLE: Platelets and Microvascular Dysfunction in Traumatic Brain Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 HEMA-G (01)]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE One goal for HIV cure researchers is to design an intervention allowing people living with HIV to discontinue their antiretroviral treatment (ART) and experience viral remission. We identified a monkey model for the related simian immunodeficiency virus (SIV) where animals can maintain virus at undetectable levels after stopping ART. In this project, we will define the immunological mechanisms that govern this monkey SIV model of post-ART viral control so that potential targets for therapeutic clinical interventions can be identified and evaluated in humans in the future.

PI_NAMEs: OCONNOR, SHELBY L (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Aftercare;Alleles;Animals;Antibodies;Antigens;antiretroviral therapy;Area;Attenuated;Award;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Chronic;Clinical;Communities;cytotoxic;cytotoxic CD8 T cells;Disease remission;Engineering;Epitopes;Exhibits;experience;Frequencies;Future;Genetic;Genotype;Goals;Grant;Haplotypes;HIV;HIV Infections;Human;Immune;Immune response;Immune system;Immunologics;in vivo;Individual;Infection;interest;Interleukin-15;Interruption;Intervention;Link;Macaca;Macaca fascicularis;Macaca mulatta;Mediating;MHC Class I Genes;Modeling;Monkeys;mutant;Natural Killer Cells;Peptides;Persons;Pharmaceutical Preparations;Phenotype;Point Mutation;Population;prevent;Research;Research Personnel;Role;Seminal;SIV;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapy design;Time;tool;Variant;Viral;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Characterizing the mechanism of post-treatment control of SIV in Mauritian cynomolgus macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Precision Medicine

ORG_CITY: EAST NORTHPORT

ORG_NAME: SURGICAL INFECTION SOCIETY FOUNDATION FOR EDUCATION AND RESEARCH

ORG_STATE: NY

PHR: Project Narrative Intra-abdominal infections continue to be associated with a complication rate of more than 20%, even for relatively simple cases, and a mortality rate exceeding 5% in many populations. These outcomes have changed little in the past 30 years. The current proposal is intended to design and apply for funding for a trial using C- reactive protein as a biomarker to individualize antimicrobial therapy for intra-abdominal infections, resulting in more precise therapy and improved outcomes.

PI_NAMEs: SAWYER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Abdominal Infection;Address;Affect;Aftercare;American;Anatomy;antimicrobial;Antimicrobial Resistance;antimicrobial resistant pathogen;Applications Grants;Area;Biological Markers;Budgets;C-reactive protein;Case Report Form;Cessation of life;Clinical;Clinical Data;Clinical Trials;clinically relevant;Colorectal Surgery;Complement;Complication;Consent Forms;Data;data management;Death Rate;Defect;design;Development;Diagnosis;Electronics;Enrollment;experimental arm;Failure;Fever;Funding;Future;Gene Expression;Gene Expression Profile;genetic signature;Grant;Image;improved;improved outcome;Infection;insight;Institutional Review Boards;Intensive Care Units;Intervention;Intra-abdominal;intraperitoneal;Investigation;Leukocytosis;Manuals;Measurement;Measures;Medical;Medicine;Metabolic;metabolomics;microbial;microbiome;microbiome signature;Monitor;Morbidity - disease rate;mortality;New Agents;novel;operation;Operative Surgical Procedures;Outcome;Patients;Pattern;personalized care;personalized medicine;Population;Population Study;precision medicine;pressure;procalcitonin;Procedures;Production;prospective;protocol development;Protocols documentation;Publishing;randomized, clinical trials;Recurrence;recurrent infection;Research Personnel;Resistance;Resolution;Safety;secondary infection;Sepsis;Serum;Severities;Site;Societies;Source;Specimen;Statistical Data Interpretation;Surgeon;Surgical Wound Infection;Techniques;Testing;Therapeutic;therapy duration;therapy outcome;Therapy trial;Time;Treatment Failure;Whole Blood;Work

PROJECT_TITLE: Biomarker-Guided Antimicrobial optimization to reduce complications from intra-abdominal infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-M (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Infectious Diseases;Physical Activity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Low cardiorespiratory fitness and chronotropic incompetence, the inability to increase heart rate adequately during exercise, may be underrecognized and treatable contributors to cardiovascular disease, especially among people with HIV. This project will describe patterns of low CRF, especially chronotropic incompetence, and risk factors for low CRF and CI among people with HIV, characterize longitudinal effects of CI on CRF, identify associations with subclinical cardiovascular disease, and conduct a pilot study of an exercise intervention for chronotropic incompetence among people with HIV. With these foundational studies, a greater understanding of the role cardiorespiratory fitness and chronotropic incompetence in cardiovascular disease may lead to insights on reducing the growing burden of cardiovascular disease among people with HIV.

PI_NAMEs: DURSTENFELD, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Age;antiretroviral therapy;Area;Atherosclerosis;Biometry;Blood Vessels;Board Certification;California;Cardiology;cardiometabolism;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;career development;Chronic;chronotropic;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Communicable Diseases;coronary computed tomography angiography;coronary plaque;Data;design;Development;Development Plans;Diabetes Mellitus;Disease;Disease Outcome;Dyslipidemias;Echocardiography;Educational Intervention;Enrollment;Environment;Epidemic;Exercise;exercise capacity;exercise intervention;Exercise Test;exercise training;experience;fluorodeoxyglucose positron emission tomography;Functional disorder;Funding;Future;General Population;Goals;Health;Heart failure;heart imaging;Heart Rate;heart rate monitor;HIV;HIV Infections;Hypertension;immune activation;improved;Individual;Infection;Inflammation;insight;Internist;Intervention;K-Series Research Career Programs;Lead;longitudinal analysis;Longitudinal cohort;Measurement;Measures;Medicine;Mentored Clinical Scientist Development Program;Mentors;Methods;Monitor;mortality;multidisciplinary;Myocardial Infarction;Natural History;Outcome;Oxygen Consumption;patient oriented;patient oriented research;Pattern;Persons;PET/CT scan;Physical activity;Pilot Projects;Population Heterogeneity;Post-Acute Sequelae of SARS-CoV-2 Infection;Preparation;prevent;professor;prospective;Quality of life;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Training;Resources;Risk;Risk Factors;Risk Marker;risk mitigation;Role;San Francisco;Smoking;Stretching;Time;Training;Translational Research;United States National Institutes of Health;Universities;VO2max

PROJECT_TITLE: Low Cardiorespiratory Fitness and Chronotropic Incompetence inHIV: Risk Factors, Cardiovascular Implications, and Exercise Training as Treatment

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Adverse Childhood Experiences (ACEs) are a major public health concern, impacting over half of the US population, and are associated with negative coping responses such as alcohol, cannabis, and other substance misuse. However, positive coping responses can be taught, disrupting negative health trajectories associated with poor mental and physical health. Garnering Resilience in Traumatized youth and families (GRIT) is a program focused on teaching self-regulation skills to adversity impacted youth and their caregivers; the program’s impact on ACE-related responses such as the early initiation of alcohol and cannabis use and other health indicators will be evaluated.

PI_NAMEs: BOUNDS, DAWN  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: 14 year old;2 arm randomized control trial;active control;active control group;Adolescent;Adoption;Adult;adverse childhood events;Adverse event;Age;aged;Alcohol consumption;alcohol use initiation;Alcohols;Attention;Behavior;Biofeedback;biological adaptation to stress;biopsychosocial;Blood Pressure;Buffers;California;Cannabis;cardiometabolic risk;Caregivers;Child;Child Abuse and Neglect;Chronic;Clinic;Cognition;Cognitive;cognitive reappraisal;Cognitive Therapy;Communities;community center;Community Health Aides;Conflict (Psychology);coping;Development;Diagnosis;digital;Drug Experimentation;early adolescence;Educational process of instructing;effective intervention;effectiveness trial;efficacy study;Emotional;Emotions;Enrollment;Equilibrium;evidence base;experience;Exposure to;Family;Family member;Functional disorder;Future;Goals;Habits;Health;health inequalities;heart rate variability;improved;Informal Social Control;innovation;Intervention;marijuana use;Mediating;Medical;Mental Health;Mentors;Minority;Modeling;National Institute of Drug Abuse;Perception;Pharmaceutical Preparations;Physical activity;physical conditioning;Population;post intervention;Poverty;prevent;Prevention program;programs;promote resilience;psychoeducation;psychoeducational intervention;Public Health;Recommendation;research to practice;resilience;response;Risk;Role;role model;Schools;Secondary Prevention;Self Medication;Shapes;skills;Sleep disturbances;sleep quality;social media;Strategic Planning;Stress;stress management;substance misuse;substance use;Substance Use Disorder;substance use prevention;Surgeon;Techniques;therapy design;Time;Trauma;traumatic stress;Trust;United States;violence exposure;Weight Gain;Youth

PROJECT_TITLE: Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences: Preventing Substance Use in Adversity-Impacted Youth

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CARLSBAD

ORG_NAME: CERESTI HEALTH, INC.

PHR: Project Narrative Hispanics/Latinos are projected to experience the largest increase in dementia prevalence of any ethnic group, with an 832% growth from 379,000 in 2012 to 3.5 million by 2060. Federal, state, local, and tribal public health partnerships have called for a pressing need to allocate resources toward reducing health disparities among minority populations most likely to be affected by dementia, including Hispanics/Latinos. To address the need for health equity in dementia care for the U.S. Hispanic/Latino population, Ceresti Health will develop an approach for deploying its proven Caregiver-Enabled Care Program (CECP) to Spanish-speaking caregivers of patients with dementia.

PI_NAMEs: SOENKSEN, DIRK  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Affect;Area;Artificial Intelligence;Caregiver support;Caregivers;Caring;Clinical Research;cohort;commercialization;cost;Data;Data Analytics;Dedications;Dementia;dementia care;Dementia caregivers;digital;Education;English Language;Enrollment;Ethnic Population;evidence base;experience;Face;Family;Family Caregiver;Family member;family support;Feeling;Future;Goals;Growth;Health;health disparity;health equity;Hispanic;Hispanic Populations;Home;Hospitalization;Human;improve minority health;improved;informal caregiver;innovation;Intervention;Knowledge;Language;Latino;Latino Population;Loneliness;Long-Term Care for Elderly;Los Angeles;loved ones;Measures;Mental Health;Minority Groups;Outcome;Participant;Patient Participation;Patients;Personal Satisfaction;Persons;population health;Positioning Attribute;Predictive Analytics;Prevalence;Prognosis;Program Sustainability;programs;promoter;Public Health;recruit;Reduce health disparities;remote monitoring;Reporting;Research;Resource Allocation;Resources;Role;satisfaction;skills;Spanish;Tablets;Testing;translational applications;Tribes;United States;usability;Validation

PROJECT_TITLE: Improving health equities for Hispanic/Latino families living with dementia by validating a Spanish-language Caregiver-Enabled Care Program (CECP) in PACE participants


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE RNA-protein interactions are essential to fundamental biological processes in humans and pathogens, and as such represent important drug targets. Structural details of these interactions are easily obtained; however, we do not yet have a predictive understanding of their biological functions. This proposal aims to investigate the structural dynamics of an RNA-protein interaction in human immunodeficiency virus 1 (HIV-1) in order to build a first of its kind quantitative model of its cellular function, as well as target it for antiviral drug development.

PI_NAMEs: KEN, MEGAN L (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affinity;antiviral drug development;Appointment;assay development;Binding;Biological Assay;Biological Models;Biological Process;Biomedical Research;biophysical techniques;Biophysics;California;career;cell behavior;Cell model;Cell Physiology;Cells;Collaborations;collaborative environment;Complex;Computer Models;computing resources;curriculum development;Data;design;Dimerization;Drug Targeting;Elements;Faculty;faculty mentor;Fluorescence;Fostering;Funding;gag Gene Products;Genetic Transcription;Genome;Genomics;Goals;graduate school;Grant;high throughput technology;HIV;HIV Genome;HIV-1;Human;Human Resources;In Vitro;in vitro Assay;Infrastructure;Institution;instrumentation;Laboratories;Leadership;Learning;Length;Libraries;Life Cycle Stages;Lipid Bilayers;Maps;Measurement;Measures;medical schools;Membrane Lipids;Mentorship;Methodology;Methods;Modeling;Modernization;Molecular Biology;Molecular Conformation;multimodality;mutant;new therapeutic target;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Output;pathogen;Pathogenicity;Plasmids;Positioning Attribute;predictive modeling;Process;programs;Property;protein oligomer;Reagent;Research;Research Personnel;Resources;RNA;RNA Conformation;RNA-Binding Proteins;RNA-Protein Interaction;Role;Running;Science;screening;skills;small molecule;small molecule libraries;Structure;student mentoring;success;synthetic biology;System;Technology;tenure track;Testing;Time;tool;Training;transcriptome sequencing;Viral;viral fitness;Viral Genome;Viral Packaging;Viral Physiology;viral RNA;virology;virtual screening;Work

PROJECT_TITLE: Predictive modeling of viral RNA cellular behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (70)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

PHR: Project Narrative This project aims to evaluate the efficacy of Mlambe: an economic and relationship-strengthening intervention for HIV-affected couples with a heavy alcohol drinker to reduce heavy alcohol use and improve HIV treatment outcomes. We will conduct a randomized clinical trial with heterosexual couples in Malawi to evaluate the health impacts of Mlambe on heavy alcohol use, viral suppression, and adherence to antiretroviral therapy, and the relationship impacts of Mlambe on partner support, couple communication, and relationship quality. We will also evaluate the costs of the intervention to assess future scalability.

PI_NAMEs: CONROY, AMY ANNE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Africa South of the Sahara;Alcohol consumption;alcohol intervention;Alcohols;antiretroviral therapy;Appointment;Area;arm;Biological Markers;Boredom;Clinical;cohesion;Communication;comparison control;Conflict (Psychology);Consumption;coping;cost;Cost Analysis;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;Couples;Deposition;drinking;Economics;Education;efficacy evaluation;Enrollment;experience;Family;financial literacy;Friendships;Funding;Future;Goals;Harm Reduction;Health;Heavy Drinking;Heterosexuals;HIV;Household;Human immunodeficiency virus test;improved;Incentives;Income;Individual;Intervention;intervention cost;intimate partner violence;Investments;Joints;Malawi;male;Meditation;meetings;men;Mental Depression;Morbidity - disease rate;mortality;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;peer;Peer Pressure;Personal Satisfaction;Persons;phosphatidylethanol;pilot trial;Poverty;poverty reduction;prevent;primary outcome;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;reduced alcohol use;Reporting;Research;Research Priority;Resources;satisfaction;Savings;scale up;secondary outcome;skills;Social support;South Africa;stem;Stress and Coping;Testing;therapy adherence;Training;transmission process;treatment as usual;Treatment outcome;two-arm study;Uganda;Unemployment;United States National Institutes of Health;Viral;Wife;Woman;Work;young woman

PROJECT_TITLE: A randomized controlled trial of an economic and relationship-strengthening intervention to reduce alcohol use in Malawi


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Cognitive Behavioral Therapy for Insomnia (CBT-I) is the first-line treatment for chronic insomnia. However, cognitive impairments may limit progress in CBT-I for older Veterans with Mild Cognitive Impairment (MCI). This study will develop and pilot test Sleep-SMART (Sleep Symptom Management and Rehabilitation Therapy), an adapted CBT-I treatment that incorporates Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) principles with a goal of improving sleep treatment and rehabilitation outcomes for Veterans with co-occurring MCI and insomnia. The innovation of this study centers on enhancing CBT-I by providing supportive cognitive strategies designed to improve treatment adherence, learning, and acceptability. We anticipate that by improving sleep we can concurrently improve daily functioning, increase quality of life, prevent or reduce late-life disability, and mitigate long-term cognitive decline in this Veteran population.

PI_NAMEs: ALMKLOV, ERIN  (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Adherence;Age;aged;Aging;Attention;barrier to care;Behavior Therapy;Chronic Insomnia;Client satisfaction;Clinical;Cognition;Cognitive;cognitive enhancement;cognitive function;Cognitive Therapy;cognitive training;Communities;Comorbid Insomnia;daily functioning;Data;Dementia;dementia risk;design;Development;disability;Dissemination and Implementation;Enrollment;Evaluation;Event;evidence base;executive function;experience;Face;fall risk;functional decline;Future;Goals;Health Services Accessibility;high risk population;Household;Impaired cognition;implementation facilitators;improved;improvement on sleep;Independent Living;Individual;Injury;innovation;Intervention;intervention mapping;Interview;Investigation;late life;Learning;Link;Manuals;Measures;Memory;Memory impairment;Mental disorders;Methodology;mild cognitive impairment;military veteran;mortality;Neurobehavioral Manifestations;Neuropsychology;normal aging;older adult;Older Population;Outcome;Pathogenesis;Patients;Persons;Pharmacological Treatment;Phase;Physical Function;Pilot Projects;pilot test;Population;Prevalence;prevent;Process;progression risk;Protocols documentation;Public Health;Quality of life;Questionnaires;Randomized, Controlled Trials;recruit;Regimen;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Project Grants;Risk;Safety;satisfaction;scale up;Secure;Severities;skills;Sleep;Sleep disturbances;Sleeplessness;standard care;symptom management;Symptoms;telehealth;Therapeutic;Therapeutic Intervention;Time;Training;treatment adherence;treatment as usual;Treatment outcome;Treatment Protocols;Veterans;Videoconferencing;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Sleep-SMART for Veterans with MCI and Insomnia: A Pilot Study

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Digestive Diseases;Heart Disease;Inflammatory Bowel Disease;Microbiome;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Ulcerative colitis (UC), a subtype of inflammatory bowel disease, is a chronic form of intestinal inflammation within the colon and rectum of the gastrointestinal tract where those affected exhibit local and systemic inflammation, gut dysbiosis, and extraintestinal manifestations such as changes (pathophysiological, electrophysiological) in cardiac function. During flare-ups UC patients exhibit twice the risk for developing atrial fibrillation (AF), the most common sustained arrhythmia worldwide caused by increased electrophysiological and structural heterogeneity. This project will examine the mechanism behind the increased risk for AF during UC disease progression.

PI_NAMEs: PELAEZ, ANDRES F (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acetylcholine;Action Potentials;Affect;Age;Agonist;Area;Arrhythmia;Atrial Fibrillation;Atrial Function;Atrophic;Attenuated;attenuation;Autonomic nervous system;Carbachol;Cardiac Myocytes;Cardiovascular system;Cells;cholinergic;Chronic;Cicatrix;Colitis;Colon;comorbidity;Connexin 43;Connexins;Data;Development;dextran sulfate sodium induced colitis;Disease;Disease Progression;Disease remission;Dose;EKG P Wave;Electrocardiogram;Electrophysiology (science);Ensure;Event;Exhibits;Extravasation;Female;Fibrosis;Flare;Frequencies;Gastrointestinal tract structure;Genetic Predisposition to Disease;Goals;gut dysbiosis;gut inflammation;gut microbiota;Heart;Heart Atrium;heart function;Heart Rate;heart rate variability;Heterogeneity;high risk;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Interleukin-6;intestinal barrier;Intestines;Length;Link;male;Mentorship;Messenger RNA;microbiota;microbiota metabolites;Modeling;mouse model;Mucous Membrane;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M2 Receptor;Muscarinics;Muscle Cells;Myopathy;Nerve;Patient risk;Patients;Perfusion;Persons;preservation;Rectum;Refractory;Research;Research Project Grants;response;Risk;Scientist;Signal Pathway;Signal Transduction;Sodium Channel;Structure;success;systemic inflammatory response;Testing;tibia;Time;Tissues;TNF gene;Training Technics;Ulcerative Colitis;Up-Regulation;Weight;Work

PROJECT_TITLE: Inflammatory Bowel Disease-Induced Inflammation Potentiates Atrial Fibrillation Risk


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Approximately half a million Veterans receiving services at the VA have Posttraumatic Stress Disorder (PTSD). PTSD is strongly associated with cognitive functioning deficits in areas of concentration, attention, memory, learning, verbal abilities, processing speed, and multitasking. The proposed research will determine the extent to which cognitive functioning deficits remain even after evidence-based PTSD treatment. Compensatory Cognitive Training (CCT) is an evidence-based intervention for cognitive problems that is effective in other Veteran populations such as those with a history of traumatic brain injury (TBI), but CCT has not yet been tested in Veterans with PTSD who don’t have a history of TBI. We will conduct a pilot randomized controlled trial (RCT) of CCT in Veterans who have been treated for PTSD but continue to have cognitive functioning deficits. We will examine feasibility, acceptability, participant characteristics, and effect size estimates in preparation for a fully-powered RCT of CCT for PTSD-related cognitive functioning deficits.

PI_NAMEs: O'NEIL, MAYA ELIN (contact)

PROJECT_TERMS: Address;Area;Attention;Auditory;behavioral clinical trial;Brain Injuries;career;Characteristics;Chronic;Clinic;clinical epidemiology;Clinical Research;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive rehabilitation;cognitive testing;cognitive training;Collaborations;comorbidity;Compensation;Data;data resource;data warehouse;Development;Educational process of instructing;effective intervention;Effectiveness;effectiveness testing;efficacy evaluation;efficacy study;Eligibility Determination;Ensure;Etiology;evidence base;Evidence based intervention;Evidence based treatment;executive function;experience;follow-up;functional improvement;Goals;Health;Health Services Research;Impaired cognition;improved;innovation;Intervention;Language Development;Lead;Learning;Licensing;Manuals;Medical Informatics;Medicine;Memory;Mental Depression;Mental Health;Mentors;Meta-Analysis;Methods;mid-career faculty;mild traumatic brain injury;military veteran;Minnesota;Motivation;multitask;Nervous System Trauma;Neurobehavioral Manifestations;Neurology;Neuropsychology;Oregon;Outcome;Participant;Patient Self-Report;Performance;Pharmaceutical Preparations;pilot test;Policies;Population;Post-Traumatic Stress Disorders;Preparation;Prevalence;processing speed;professor;Psychiatry;Psychologist;Psychotherapy;Quality of life;Randomized, Controlled Trials;Recording of previous events;Recovery of Function;recruit;Rehabilitation Centers;rehabilitation research;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Residual state;Resources;Sample Size;Schizophrenia;Science;Services;severe mental illness;Severities;Short-Term Memory;side effect;Site;skills;social;Stress;Symptoms;Teaching Method;Testing;Training;Training Programs;Traumatic Brain Injury;treatment as usual;treatment response;Universities;verbal;Verbal Learning;Veterans;visual learning;Vocation

PROJECT_TITLE: Assessment and Treatment of Cognitive Functioning Deficits in Veterans with PTSD

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE In its most severe form, food allergy can trigger life-threatening anaphylaxis. We recently discovered that susceptibility to oral anaphylaxis is driven by intestinal permeability to food allergens and that this permeability is genetically regulated and potentially treatable by drugs. We aim to discover the specific mechanisms controlling gut permeability in order to (1) identify new drugs to prevent anaphylaxis upon ingestion of allergens and (2) discover diagnostic markers that can identify individuals most at risk of anaphylaxis to food.

PI_NAMEs: EISENBARTH, STEPHANIE CAROLINE;WILLIAMS, ADAM  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Affect;Alleles;Allergens;Allergic;Allergy to eggs;Allergy to peanuts;Anaphylaxis;Antibodies;Antigens;autosome;Backcrossings;Basophils;Blood;Bone Marrow;C3H/HeJ Mouse;C57BL/6 Mouse;Candidate Disease Gene;Cell Count;Cell Differentiation process;Cell Physiology;cell type;Cellular biology;Child;Chimera organism;Chromosome 8;Chromosome Mapping;CRISPR/Cas technology;Data;diagnostic biomarker;diagnostic strategy;DNA Sequence Alteration;Enzymes;Epithelial Cells;Exhibits;experimental study;FDA approved;Food;food allergen;Food Hypersensitivity;forward genetics;gastrointestinal epithelium;Genes;Genetic;genetic resistance;Genetic Screening;Genetic Transcription;genomic locus;Goals;Goblet Cells;Human;IgE;In Vitro;in vivo;Individual;Ingestion;Inherited;intestinal epithelium;Intestinal permeability;Lead;Life;Link;Maps;mast cell;Mediating;microbiota;Molecular;mouse model;Mouse Strains;Mucous Membrane;Mus;novel;novel therapeutics;Oral;oral immunotherapy;Pathway interactions;Patients;Permeability;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;Predisposition;prevent;Process;programs;Quantitative Trait Loci;Reaction;Recording of previous events;Regulation;Resistance;resistance gene;Resolution;Risk;Secretory Cell;single-cell RNA sequencing;SNP genotyping;Surface;System;targeted treatment;Testing;uptake;validation studies;Work

PROJECT_TITLE: Determinants of oral anaphylaxis to food

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LINCOLN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Understanding how normal processes in the cell operate incorrectly at the molecular level during disease initiation and progression is vital to develop strategies to control disease. Interdisciplinary research that integrates methodologies across traditional fields is needed to advance the definition of molecular processes. The proposed predoctoral program in Molecular Mechanisms of Disease at the University of Nebraska- Lincoln will use collaborative research projects, student-centered teaching, and diverse career development opportunities to develop a workforce of team-oriented scientists with critical expertise in the interdisciplinary study of disease progression.

PI_NAMEs: BECKER, DONALD F (contact);HARRIS, EDWARD N

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Disease;Molecular

PROJECT_TITLE: Molecular Mechanisms of Disease

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative Our lab studies how human cells help one of their most abundant proteins achieve its correct three-dimensional shape; this protein enables production of all other proteins and is blocked by a drug with pre-clinical efficacy against SARS-CoV-2. We also study how human cells adapt to stress by remodeling their intracellular membrane compartments by a quality control process that staves-off neuronal degeneration with age.

PI_NAMEs: DENIC, VLADIMIR  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Age;Amino Acids;Area;Autophagocytosis;Autophagosome;Biochemical;Biogenesis;biological adaptation to stress;Cell Culture Techniques;Cells;Cues;Degradation Pathway;Dissection;Encapsulated;Endoplasmic Reticulum;Genetic Screening;Genomics;Heat-Shock Response;Human;interest;Intracellular Membranes;Link;Microscopy;Molecular Chaperones;multicatalytic endopeptidase complex;mutant;Nerve Degeneration;Organelles;Peptide Elongation Factor 1;peroxisome;Pharmaceutical Preparations;Phenotype;Physiological;preclinical efficacy;Process;Production;protein degradation;protein structure function;Proteins;proteostasis;Quality Control;receptor;reconstitution;Shapes;Signal Transduction;Starvation;Stress;System;Testing;Theoretical model;Ubiquitin;Yeasts

PROJECT_TITLE: Mechanistic dissection of eukaryotic protein biogenesis and degradation pathways


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: Project Narrative Fluid flows over the external surface of cells serve as sources of information during cell-cell communication events, but how cells sense and respond to flow-derived signals is not understood. We propose to use the tractable zebrafish left-right patterning system to determine fundamental mechanisms by which cells generate, sense and interpret fluid flows using advanced genetic and imaging approaches. Since abnormal flows occur in a range of diseases, our work promises new opportunities for improving human health.

PI_NAMEs: GRIMES, DANIEL T (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3' Untranslated Regions;Address;Cell Communication;Cell surface;cell type;Cells;Chemicals;CRISPR/Cas technology;Disease;Embryo;Environment;Erinaceidae;Esthesia;Event;fluid flow;frontier;Gene Expression;gene repression;Genes;Genetic;genetic approach;Health;Homeostasis;host-microbe interactions;Human;imaging approach;improved;in vivo;Knowledge;Left;Malignant Neoplasms;Mediating;Membrane Proteins;MicroRNAs;Modeling;novel;organ growth;Output;Pattern;posttranscriptional;programs;quantitative imaging;Reporter;Repression;Research;Resolution;RNA-Binding Proteins;Role;Sensory;Side;Signal Pathway;Signal Repression;Signal Transduction;Site;Source;Surface;System;Testing;Work;Zebrafish

PROJECT_TITLE: Cell-cell communication mediated by fluid flows

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Regenerative Medicine;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: This research will: promote understanding of how psychosocial factors impinge on cell therapy;  enhance translation from preclinical to clinical studies; and elucidate how to increase the  efficacy of cell-based therapies on urinary sphincter deficiency-associated stress urinary  incontinence.

PI_NAMEs: SHIVELY, CAROL A. (contact);WILLIAMS, JAMES KOUDY

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Abdomen;Adrenal Glands;Affect;Anti-Inflammatory Agents;Apoptosis;Arousal;Autologous;Behavioral;Behavioral Sciences;Bladder;Blood Vessels;bone healing;Bone Marrow;Bone Marrow Cells;cell injury;Cell Proliferation;Cell Therapy;Cells;Characteristics;chemokine;Cherry - dietary;Circulation;Clinical Research;Collagen;CXCR4 Signaling Pathway;Data;design;Dexamethasone;Educational workshop;efficacy evaluation;Elastin;Estrogen deficiency;Exhibits;experience;Female;Fiber;Fibrosis;Functional Regeneration;Future;Gene Expression Profile;Goals;hematopoietic tissue;Hydrocortisone;Hypothalamic structure;Hypoxia;Impairment;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Knowledge;Label;Literature;Lower urinary tract;Lymphocyte;Macaca fascicularis;Macrophage;Measures;Mediating;Modeling;molecular pathology;Monkeys;monocyte;multidisciplinary;Muscle;Myoblasts;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Nerve;nerve supply;nonhuman primate;Ovarian;ovarian dysfunction;Pathway interactions;Pattern;Phenotype;Physiological;Pituitary Gland;pre-clinical;preclinical study;preclinical trial;pressure;Primates;Process;prospective;Psychological Stress;Psychosocial Factor;Psychosocial Stress;Publishing;Randomized;regenerative;Regenerative Medicine;regenerative treatment;Reporting;Research;response;Rest;senescence;Signal Pathway;Skeletal Muscle;small social group;social;Social status;spectrograph;Sphincter;stem cells;Stress;Stress Urinary Incontinence;Stromal Cell-Derived Factor 1;Sympathetic Nervous System;Testing;tissue regeneration;tissue repair;Tissues;Translational Research;Translations;Urethra;urinary;Urinary Incontinence;Urologic Diseases;Urology;vascular inflammation;Vascularization;Whole Blood;Woman

PROJECT_TITLE: Psychosocial Stress Effects on Regenerative Medicine Therapies for Lower Urinary Tract Disorders in Nonhuman Primates

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Chronic Pain;Diabetes;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Our work is aimed at gaining a better understanding of molecular events that drive diabetic neuropathic pain and then using this knowledge to identify new molecular targets for diabetic neuropathic pain treatment. We have found a key stress signaling pathway surrounding mRNA translation that regulates nociceptor excitability that occur in diabetic neuropathy. The combined use of pharmacology, genetics, and next generation sequencing technologies across mouse, rat, and human model systems in our project will give unprecedented insight into mechanisms of diabetic neuropathic pain and will identify novel therapeutic opportunities to treat this highly prevalent and exceedingly difficult to manage disorder.

PI_NAMEs: CHATTOPADHYAY, MUNMUN ;YOUSUF, MUHAMMAD SAAD  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Advanced Glycosylation End Products;Affect;Afferent Neurons;Affinity Chromatography;Amino Acids;Animal Model;Animals;Behavior;biological adaptation to stress;Biological Markers;Biological Models;Blinded;Blood Glucose;cell type;Cells;cellular imaging;Chemicals;chronic pain;Clinical;clinical efficacy;clinically relevant;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Neuropathies;diabetic patient;diabetic rat;disability;Disease;Disease Management;Disease Progression;Dose;drug efficacy;Drug Monitoring;Electrophysiology (science);Eukaryotic Initiation Factors;Event;experimental study;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Glycolysis;Goals;Home;Human;human model;Hypersensitivity;Individual;inhibitor;inhibitor therapy;Injections;insight;Intervention;Knock-out;Knowledge;Link;LoxP-flanked allele;Lysine;Mechanics;Mediating;Medical;Messenger RNA;Modeling;Molecular;Molecular Target;mouse genetics;mRNA Translation;Mus;Nerve Fibers;Nerve Tissue;Neurons;Neuropathy;new therapeutic target;next generation sequencing;Nociceptors;Non-Insulin-Dependent Diabetes Mellitus;non-opioid analgesic;novel;novel therapeutics;Open Reading Frames;Organ Donor;Pain;pain behavior;Pain management;pain model;painful neuropathy;patch clamp;Pathogenesis;Pathology;Pathway interactions;Patient Selection;patient stratification;Patients;Peripheral Nerves;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphorylation;Plasma;Population;prevent;Production;Protein Biosynthesis;protein function;protein misfolding;Publishing;Pyruvaldehyde;Quality of life;Rattus;recruit;Repression;Research;response;Ribosomes;Risk;Rodent Model;Role;Science;Serum;sex;Signal Pathway;Signal Transduction;specific biomarkers;Spinal Ganglia;Spinal nerve structure;spontaneous pain;Stress;stressor;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapy development;Tissue Donors;Transcript;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Translating;translational approach;translational model;Translations;translatome;Type 2 diabetic;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Targeting methylglyoxal-induced diabetic neuropathic pain through the integrated stress response

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The grand challenge in the life sciences during the 21st century is understanding how all molecules of life interact, working in concert to give rise to the living state, normal and diseased. Molecular biophysics is the interdisciplinary field that will provide this understanding. The Program in Molecular Biophysics trains predoctoral researchers to solve biomedical problems from first principles.

PI_NAMEs: FLEMING, KAREN G. (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Biophysics;Molecular;programs

PROJECT_TITLE: Program of Molecular Biophysics

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: EL PASO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

PHR: Project Narrative The proposed project will elucidate the molecular functions of previously unstudied estrogen-regulated divergent transcription and its products. The results of the study will identify novel targets for estrogen-driven diseases and will provide the research community with unique tools for studying estrogen-dependent signaling.

PI_NAMEs: GADAD, SHRIKANTH  (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: Address;Affect;Androgens;Binding;Biochemical;Biochemistry;Biological Assay;Breast;Cardiovascular Diseases;Cell Fractionation;cell growth;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cessation of life;Chromatin;Chromatin Loop;chromatin remodeling;Code;Collaborations;Communication;Communities;Complex;County;Data;Dimerization;Disease;DNA Polymerase II;Elements;Endocrine;endometriosis;Enhancers;Enzymes;Epigenetic Process;epigenomics;ESR1 gene;Estrogen receptor positive;Estrogens;Federal Government;Fibroid Tumor;Functional disorder;Gene Combinations;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Genomic approach;Genomic Segment;Genomics;global run on sequencing;Goals;Growth;Hispanic-serving Institution;Histones;Hormones;insight;Ligands;Malignant Breast Neoplasm;MCF7 cell;Molecular;Molecular Mechanisms of Action;novel;Outcome;Pathway interactions;Pattern;Play;Positioning Attribute;programs;Proliferating;promoter;Property;Proteins;Proteomics;receptor;recruit;Research;response;RNA;Role;Signal Transduction;Site;spatiotemporal;Texas;Tissues;tool;Transcript;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: Analysis of divergent transcripts in estrogen-dependent signaling.


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EDINBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: PROJECT NARRATIVE It is well known that there are many cell-specific functions and behaviors that have been missed by the limitations of having to rely on easily obtainable cells such as blood cells or lymphoblastoid cell lines for epidemiological studies of disease causation, risk factors, and biomarker identification. Advances in iPSC technologies now allow us to consider non-invasive large-scale deep cellular phenotyping efforts on disease-appropriate cell types in human subjects from easily obtained blood cells. Using a rigorous experimental approach benefiting from subjects from extended pedigrees, we propose to test for genotype×environment interaction (GEI) experimentally by examining cellular phenotypic variation before and after a controlled environmental stress challenge. We expect that the proposed project will establish the cellular basis of GEI influencing complex phenotypes of relevance to human health.

PI_NAMEs: BLANGERO, JOHN ;CURRAN, JOANNE E. (contact);GALAN, JACOB ANTHONY;KUMAR, SATISH ;PARSONS, JASON

PROJECT_TERMS: Age;Aging;Air Pollution;alveolar epithelium;Behavior;Benzo(a)pyrene;Biological;biological age;Biological Markers;biomarker identification;Blood Cells;Brain;Cell Line;cell type;Cells;Cellular Stress;Complex;Cryopreservation;Derivation procedure;design;Detection;Dimensions;Disease;Environment;Environmental Exposure;Environmental Pollutants;Epidemiology;epidemiology study;Epigenetic age;epigenetic memory;Etiology;Family Study;fitness;frailty;Gene Expression Profile;Generations;Genes;Genetic;genetic approach;genetic pedigree;Genetic study;Genetic Transcription;Genotype;Health;Heritability;Heterogeneity;Homeostasis;Human;human model;Human Resources;human subject;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;Length;lymphoblastoid cell line;Measures;Metabolism;Mexican Americans;Mitochondria;nerve stem cell;neurotoxic;novel;novel strategies;Organ;Participant;Pathway interactions;Phenotype;phosphoproteomics;pleiotropism;Pollution;Research Design;response;Risk Factors;single cell sequencing;Snake Venoms;Stress;stress resilience;Tail;Techniques;telomere;Testing;Time;Variant;Whole Organism

PROJECT_TITLE: Experimental Cellular Approaches to Genotype × Environment Interaction


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Safe and affordable housing provides a critical foundation for health; however, its relationship with cancer care and outcomes is largely unknown. This study examines whether patients with cancer who receive federal housing assistance are more likely to receive timely, guideline-concordant care for breast, colorectal, prostate, and lung cancers compared to similar patients without housing assistance.

PI_NAMEs: POLLACK, CRAIG EVAN (contact);YABROFF , ROBIN

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Advisory Committees;American;American Cancer Society;Area;Attention;Breast;Buffers;cancer care;cancer health disparity;Cancer Patient;cancer site;Cancer Survivor;cancer therapy;Caring;Cells;clinical care;Color;Colorectal;Colorectal Cancer;cost;Data;Data Linkages;Data Set;design;Diagnosis;Diagnostic Procedure;Disparity;Early Diagnosis;Eligibility Determination;Emergency department visit;Equity;Ethnic Origin;experience;Family;financial toxicity;Foundations;Goals;Guidelines;Health;Health Personnel;Health Services;Health Services Research;Healthcare Systems;high risk;Home;Household;Housing;improved;Incidence;Individual;Inequity;innovation;Institutional Racism;Intervention;Investigation;Knowledge;Link;long-standing disparities;Low income;low socioeconomic status;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medicare;Medicare claim;National Cancer Institute;Neighborhoods;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;novel;older adult;Outcome;Patient-Focused Outcomes;Patients;personalized medicine;Policies;Policy Maker;policy recommendation;programs;Prostate;Psychological Stress;Public Housing;Quality of Care;Race;racial disparity;Recording of previous events;Research;residence;Risk Factors;Risk Reduction;Role;Services;social;social factors;Social Work;socioeconomic disparity;Stage at Diagnosis;survivorship;Testing;Time;Toxicant exposure;U.S. Department of Housing and Urban Development;voucher;Waiting Lists

PROJECT_TITLE: Housing assistance, Outcomes, Medicare, and SEER (HOMES): using a novel data linkage to understand cancer inequities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE We propose to build on our supporting evidence by elucidating mechanistic aspects of the liver microenvironment that impact breast cancer liver metastasis. We propose to employ novel technologies, validate findings with unique patient cohort datasets and tissue specimens, and test new strategies to eliminate liver metastasis in our preclinical models. The knowledge we obtain from our proposed work should provide entry points for clinical development of new life-saving breast cancer therapies.

PI_NAMEs: MCALLISTER, SANDRA S (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;Anthracycline;Bar Codes;Biopsy Specimen;Body System;Brain;Breast biopsy;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;cancer cell;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical development;Clone Cells;cohort;Combination Drug Therapy;Cyclophosphamide;Cytotoxic T-Lymphocytes;Data;Data Set;design;Detection;Diagnosis;Drug resistance;effective therapy;FDA approved;fitness;Goals;Heterogeneity;high dimensionality;Immune;Immune checkpoint inhibitor;immune function;Immune system;immune system function;Immunofluorescence Immunologic;immunosuppressed;Immunosuppression;Impairment;improved;Investigation;Knowledge;Life;Liver;Lung;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methods;Modeling;Molecular;mouse model;multiple omics;Mus;Natural Killer Cells;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new technology;novel therapeutic intervention;Operative Surgical Procedures;Organ;Patient imaging;Patients;peripheral blood;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;Prior Chemotherapy;Process;Prognosis;Proliferating;Property;Radiation;receptor;Resistance;response;Sampling;Site;Specimen;Stains;standard care;success;T-Lymphocyte;taxane;Testing;Tissue Sample;Tissues;transcriptome sequencing;Treatment Protocols;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Understanding the impact of chemotherapy on breast cancer metastasis and immune function in the liver

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cancer cachexia, which is particularly prevalent in pancreatic cancer, is a multifactorial syndrome that encompasses metabolic disruptions, hormonal abnormalities, and inflammation leading to negative energy balance and breakdown of muscle and adipose tissue. The breakdown of muscle tissue is particularly devastating because is negatively impacts physical function and quality of life, and also impacts patient’s ability to withstand the dose and frequency of aggressive conventional treatments for the disease and thus impacts survival. In the current work we will investigate the role of Cellular Communication Network Factor 2 (CCN2), also known as connective tissue growth factor (CTGF), which is produced by pancreatic tumors and in skeletal muscles in response to pancreatic cancer, in driving cachexia and muscle dysfunction.

PI_NAMEs: JUDGE, SARAH M (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Adipocytes;Adipose tissue;Antibodies;Atrophic;Attenuated;autocrine;Automobile Driving;Cachexia;Cancer Cachexia;Cancer Patient;cancer therapy;cancer type;Cell Differentiation process;Cell Nucleus;Cell secretion;cell type;Cells;Communication;connective tissue growth factor;conventional therapy;cytokine;Data;Development;Disease;Dose;effective therapy;EGFR inhibition;energy balance;Engraftment;Epidermal Growth Factor Receptor;Event;Family;fat wasting;Fatty acid glycerol esters;Fibrosis;Frequencies;Functional disorder;gene repression;Genes;Genetic;Growth Factor Inhibition;HIF1A gene;High Prevalence;Hormonal;Human;Hypoxia;Impairment;In Vitro;in vivo;in vivo Model;Inflammation;Injury;Interleukin-6;Knock-out;Knockout Mice;KPC model;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Mediator;Metabolic;Molecular;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;muscle regeneration;Muscle Weakness;Muscular Atrophy;Myopathy;Nature;Neoplasm Metastasis;neoplastic cell;NF-kappa B;Nutritional Support;Operative Surgical Procedures;overexpression;Pancreas;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Peripheral;pharmacologic;Phenotype;Physical Function;Play;preservation;Process;Production;progenitor;Proteins;Quality of life;receptor;Recombinants;repaired;respiratory;response;Role;Serum;Signal Transduction;single nucleus RNA-sequencing;Skeletal Muscle;skeletal muscle wasting;small hairpin RNA;Smooth Muscle Myocytes;Syndrome;Testing;Time;Tissues;transcriptome sequencing;translational potential;tumor;tumor growth;unpublished works;Up-Regulation;vector;Work

PROJECT_TITLE: Matricellular proteins of the CNN family as regulators of tumor-induced cachexia

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project is relevant to public health because preterm birth and oxygen therapy in premature infants causes incurable vision impairment and myopia. Results from the study will advance our understanding of why vision problems and myopia of prematurity occurs in almost 1 of every 10 infants born in the United States. Our ultimate goal is to develop preventive and therapeutic strategies to preserve vision in premature infants.

PI_NAMEs: ZHANG, DAO-QI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Ablation;Amacrine Cells;Animal Model;Animals;Anterior;Anterior eyeball segment structure;Autopsy;Biometry;Blindness;Blood Vessels;Brain;Child;cholinergic;combat;Contrast Sensitivity;Cornea;Data;Development;Dimensions;Dopamine;Enzymes;Event;experience;Eye;Eye Development;Eye diseases;Genetic Techniques;Goals;Growth;Human;Impairment;Infant;insight;Interneurons;Knock-out;Lead;Length;lens;Light;Mediating;Molecular;Mus;Myopia;neonatal mice;neuron development;Neurons;novel;novel therapeutic intervention;Outcome;Oxygen;Oxygen Therapy Care;patch clamp;Pathogenesis;Pathway interactions;pharmacologic;postnatal;Pregnancy;premature;Premature Birth;Premature Infant;prenatal;preservation;Preventive;Primates;Production;Public Health;rational design;Recovery;Refractive Errors;response;Retina;retina blood vessel structure;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Retinopathy of Prematurity;Signal Pathway;Signal Transduction;Source;starburst amacrine cell;System;Testing;Therapeutic;Tyrosine 3-Monooxygenase;United States;Vascular System;Vertebrate Photoreceptors;Vision;Visual;Visual Acuity;Visual impairment;Work

PROJECT_TITLE: The Underlying Mechanisms of Visual Impairment and Myopia in Prematurity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: More than 8,000 Veterans undergo abdominal aortic aneurysm (AAA) repair each year. Nearly 70% are treated with endovascular abdominal aortic aneurysm repair (EVAR), where a stent covered in fabric is used to reinforce the weakened aorta. Food and Drug Administration (FDA) directives mandate surveillance imaging after EVAR life-long, typically provided via a once-yearly contrast-enhanced CT scan. In this proposal, we use a mixed-methods design to (1) qualitatively assess Veteran, family, and health care team members’ attitudes and beliefs surrounding surveillance imaging after EVAR and (2) quantitatively examine observational data sources to best characterize surveillance imaging risks, benefits, and outcomes after EVAR. This evidence will be shared with Veterans and key stakeholders to better inform use of surveillance imaging after EVAR.

PI_NAMEs: GOODNEY, PHILIP P (contact);SPANGLER, EMILY LOUISE

PROJECT_TERMS: Abdominal Aortic Aneurysm;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adherence;adverse outcome;Affect;Aging;Aorta;Area;Arteries;Attitude;Belief;Blood flow;Blood Vessels;Caregivers;Caring;Categories;Cessation of life;Chronic;Clinical Data;cohort;comorbidity;Complex;contrast enhanced computed tomography;Cox Models;Dangerousness;Data;Data Sources;data warehouse;Decision Analysis;Decision Making;design;Dyes;Elderly;Ensure;Equilibrium;experience;Family;follow-up;Funding;Future;Guidelines;Health Personnel;Image;improved;Incidence;Incidental Findings;Injury to Kidney;innovation;Intervention;Interview;Intestines;Kidney;Knowledge;Learning;Long-Term Care;Lung;markov model;Measures;Medical Care Team;member;Methodology;Methods;Modality;Modeling;nephrotoxicity;Nodule;Online Systems;Operative Surgical Procedures;Outcome;Pathway interactions;Patient Recruitments;Patients;podcast;Population;pressure;primary outcome;Procedures;Protocols documentation;Provider;Quality of life;recruit;Regimen;repaired;Research Design;Risk;Rupture;Rural;Scanning;secondary outcome;serial imaging;Societies;Stents;Subgroup;surveillance imaging;surveillance strategy;Telephone;Testing;Textiles;ultrasound;United States Food and Drug Administration;Variant;Veterans;Work;X-Ray Computed Tomography

PROJECT_TITLE: Surveillance priorities and outcomes for Veterans treated with endovascular abdominal aortic aneurysm repair

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Diabetes is a common health condition among older Veterans. It is important for patients and their healthcare providers to understand the benefits and risks of diabetes medications. A particular area of uncertainty is when patients require additional treatment after an initial medication, metformin, is ineffective. This study advances diabetes care by studying the effects of generic and newer diabetes medications when added to metformin. We will use data from a large nationwide sample of Veterans 65 years and older and apply methods to carefully control for factors that may bias the results. The study will then compare three commonly used diabetes medications that may be added to the treatment regimen, and evaluate risks of mortality, diabetes complications, healthcare utilization, and cost effectiveness. This will ultimately help healthcare providers and patients make informed treatment decisions that align with patients’ unique circumstances and goals of care.

PI_NAMEs: CONLIN, PAUL R (contact)

PROJECT_TERMS: Academic Detailing;Acceleration;Adherence;adverse outcome;Affect;age group;Agonist;Ambulatory Care;Area;Attenuated;Benefits and Risks;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;care costs;care systems;Caring;Characteristics;Chronic Kidney Failure;Clinical;Clinical effectiveness;Clinical Practice Guideline;Clinical Trials;cohort;Collaborations;comorbidity;comparative effectiveness;Complex;Complications of Diabetes Mellitus;Congestive Heart Failure;cost;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Costs and Benefits;Data;Diabetes Mellitus;diabetes risk;Disease Progression;Dual Enrollment;economic evaluation;Education;Emergency department visit;Equilibrium;Event;evidence base;Eye diseases;GLP-I receptor;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;Health;Health Care Costs;health care service utilization;Health Personnel;Healthcare Systems;Heart failure;Hospitalization;human old age (65+);Hyperglycemia;Hypoglycemia;improved outcome;Incidence;incremental cost-effectiveness;inhibitor;innovation;insight;Kidney Diseases;Life Expectancy;Marketing;markov model;Measures;medical specialties;Medicare;medication compliance;Metformin;Methodology;Methods;Modeling;mortality;mortality risk;Neuropathy;Observational Study;older adult;Outcome;Patients;Pattern;Pharmaceutical Preparations;pharmacy benefit;Pharmacy facility;Policy Maker;programs;Provider;Quality-Adjusted Life Years;Quasi-experiment;Recommendation;Retinal Diseases;Risk;Risk Factors;Risk Reduction;risk/benefit ratio;Sampling;Services;side effect;Sodium;Subgroup;Sulfonylurea Compounds;symporter;Techniques;Treatment Protocols;Uncertainty;Veterans;Work

PROJECT_TITLE: Comparative and cost effectiveness of diabetes medications

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Our overall goal is to understand the molecular mechanisms how the cell cycle and differentiation progression are linked and can be synergistically manipulated to regulate terminal cell differentiation of adipocytes and thus fat mass. Understanding how to regulate adipocyte differentiation has many immediate applications for treating the current worldwide epidemic of obesity. The results of this proposed work will likely have applicability to brown fat, skeletal muscle, pancreatic beta, and other terminal cell differentiation processes important for human health.

PI_NAMEs: TERUEL, MARY N (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Adolescent obesity;Adult;Body Weight decreased;Brown Fat;CDK2 gene;CDK4 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Differentiation process;Cell division;Cells;cellular imaging;Child;Clonal Expansion;Cyclins;Ensure;experimental study;Fatty acid glycerol esters;Functional disorder;G1 Phase;Genetic;Goals;Health;Human;Hypertrophy;imaging approach;In Vitro;in vivo;inducible gene expression;inhibitor;Injections;interest;Knock-out;Knockout Mice;Link;lipid biosynthesis;live cell imaging;Maintenance;Metabolic;Metabolic Diseases;Methods;Molecular;mouse model;Mus;Muscle;neuron regeneration;Obesity;Obesity Epidemic;Outcome;Pancreas;Persons;Phase;Process;progenitor;programs;Proliferating;Publishing;regenerative tissue;Reporter;Research;Risk;Role;Skeletal Muscle;stem cells;synergism;Testing;Therapeutic;Time;Tissue Differentiation;Tissues;Work

PROJECT_TITLE: Cell cycle control of adipogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE The objective of the proposed project is to conduct rigorous longitudinal clinical validation of MarkVCID-selected biomarkers in a diverse cohort free of dementia, and to investigate the associations of these biomarkers with SVD neuropathologic indices, working synergistically with other consortium sites and contributing scientific expertise, experimental infrastructure, and scientific guidance. Rigorously validated, high-quality SVD biomarkers will have broad clinical implications including refined participant selection and enhanced monitoring of the treatment response in clinical drug and prevention trials, as well as long term implications in the advancement of diagnosis, prevention and treatment of SVD related cognitive decline and dementia in aging.

PI_NAMEs: ARFANAKIS, KONSTANTINOS  (contact);SCHNEIDER, JULIE A.

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Academic Medical Centers;African American;African American population;Aging;Agreement;Alzheimer's Disease;Arterioloscleroses;Atherosclerosis;Automation;Autopsy;Biological Markers;biomarker selection;Blood;Blood Vessels;blood-based biomarker;Brain;Caucasians;Cerebral Amyloid Angiopathy;Cerebral small vessel disease;Cessation of life;Characteristics;Clinical;clinical biomarkers;Clinical Trials;Cognition;Cognitive;cohort;Cohort Studies;Communities;Computer software;Data;Data Set;data sharing;Dementia;Diagnosis;Enrollment;follow-up;Future;Hemorrhage;high risk;Illinois;imaging biomarker;Impaired cognition;indexing;Individual;Infarction;Infrastructure;Latino;Latino Population;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Memory;Microscopic;Microvascular Dysfunction;mild cognitive impairment;Minority;Mission;Monitor;Names;neuropathology;non-demented;novel marker;older adult;Parents;Participant;Pathologic;Pathology;Performance;Periodicals;Pharmaceutical Preparations;Population Heterogeneity;Prevention;Prevention trial;Process;recruit;religious order study;Research;research clinical testing;Research Personnel;research study;Resources;Site;Technology;Testing;Time;Training;treatment response;Update;Validation;White Matter Disease;Work

PROJECT_TITLE: Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementia


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Prevention;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Anxiety and mood disorders are the most prevalent psychiatric conditions, with deficits in cognitive control and emotional reactivity representing proposed mechanisms of disorder onset. Sleep is critical for the optimal neurobehavioral functioning of these transdiagnostic mechanisms, and sleep disturbances, specifically in the deepest stage of sleep (i.e., slow-wave sleep), are implicated in anxiety and mood disorders. The present study will experimentally enhance sleep slow-wave activity via acoustic stimulation and assess neurobehavioral improvements in cognitive control and emotional reactivity in young adults experiencing anxiety and depression symptoms to understand the role of slow-wave sleep in emotion regulation and inform targeted sleep-based preventative treatments for anxiety and mood disorders.

PI_NAMEs: STEPAN, MICHELLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Acoustic Stimulation;Acoustics;adequate sleep;Affective;affective neuroscience;Amygdaloid structure;Anterior;Anxiety;Anxiety Disorders;anxiety symptoms;Arousal;Aversive Stimulus;Behavior assessment;Brain;career;cingulate cortex;cingulate gyrus;circadian;Clinical;Cognitive;cognitive control;cognitive process;comorbidity;Coupling;Crossover Design;density;depressive symptoms;Development;Devices;Diagnostic;disorder prevention;Dorsal;Electroencephalography;emotion regulation;Emotional;experience;Female;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Health behavior;Image;improved;Individual;Inferior;information processing;innovation;Insula of Reil;Investigational Therapies;Knowledge;Measures;medical schools;Mental Depression;Mental disorders;Mental Health;Mentorship;Modeling;Mood Disorders;National Institute of Mental Health;negative affect;neural circuit;neurobehavioral;Neuronal Plasticity;Onset of illness;Outcome;Parietal Lobe;Participant;Patient Self-Report;Patient-Focused Outcomes;Performance;Physiological;Play;Polysomnography;Positioning Attribute;Predictive Factor;Prefrontal Cortex;Preventive treatment;primary outcome;Principal Investigator;Process;programs;Psychiatry;Randomized;Recording of previous events;REM Sleep;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;Schedule;Science;Scientist;skills;Sleep;Sleep Architecture;Sleep disturbances;sleep health;Sleep Stages;Slow-Wave Sleep;Synapses;Techniques;Testing;Thalamic structure;Therapeutic;therapeutic target;Training;Training Activity;treatment of anxiety disorders;Universities;Work;young adult

PROJECT_TITLE: The Effect of Acoustic Enhancement of Slow-Wave Activity on Cognitive Control and Emotional Reactivity in Young Adults with Anxiety and Depression Symptoms


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Although physical activity is an important component of pediatric asthma management, urban minority children with asthma face many barriers to participation in sports and other forms of physical activity. The current study may have a profound impact on public health because it aims to rigorously evaluate the effectiveness of a novel school-based intervention that addresses key barriers to physical activity in urban minority children with asthma. Should the intervention prove successful in reducing symptoms and improving health of urban children with asthma, it has the potential to serve as a model for improved asthma care in urban communities.

PI_NAMEs: REZNIK, MARINA  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Absenteeism;Accelerometer;Address;Adherence;Adoption;Affect;African American;Age;aged;Asthma;asthma exacerbation;Awareness;Caregivers;Caring;Child;Childhood Asthma;Clinical;Clinical Trials;Collaborations;Communities;community collaboration;Community Health Aides;comparison group;contextual factors;demographics;design;disorder control;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;elementary school;Ensure;Evaluation;Exercise;experience;Face;Family;feasibility testing;Feedback;Fright;functional outcomes;Guidelines;Health;health care service utilization;Health system;high risk;Hispanic;Human Resources;implementation intervention;improved;inner city;Intervention;intervention effect;Low income;Maintenance;Measures;Mediating;Mediation;Mediator;meetings;minority children;Modeling;Morbidity - disease rate;New York;Notification;novel;Outcome;Outcome Measure;Parents;Pathway interactions;Pharmaceutical Preparations;Phase;Physical activity;Physical Education;physical inactivity;physical state;Pilot Projects;pilot test;Policies;Prevalence;Preventive;Primary Care Physician;primary outcome;Procedures;Process;programs;Public Health;pulmonary function;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;reduce symptoms;school health;Schools;secondary outcome;Self Efficacy;Self Management;Severities;social factors;social stigma;Sports;Strenuous Exercise;Students;Symptoms;teacher;Testing;Time;treatment as usual;urban children;Urban Community;Urban Health;urban minority;urban school;Work

PROJECT_TITLE: Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]