NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative The proposed project seeks to create a California early psychosis network (EPI-CAL) using a core assessment battery of valid, low burden measures and an innovative mHealth technology platform to collect client-level data, visualize data via clinician dashboard for treatment planning, and integrate across clinics to provide de- identified data to the national coordinating hub. Research capacity for the network will be tested via development and validation of a measure of the Duration of Untreated Psychosis (DUP) that is feasible for use in community settings. The proposed California network will contribute systematically collected outcomes data on approximately 1000 FEP clients over 5 years, from 6 community and 6 university EP clinics, to enhance the development of a national EP network, supported by the NIMH EPINET program.

PI_NAMEs: NIENDAM, TARA ANN (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adoption;California;care outcomes;care providers;Caring;Client;Client satisfaction;Clinic;Clinical;clinical care;Collaborations;Communities;community setting;Coordinated Specialty Care;Custom;dashboard;Data;Data Analyses;data de-identification;data infrastructure;data integration;data visualization;Development;Dimensions;duration of untreated psychosis;early psychosis;Economic Burden;Effectiveness;Eligibility Determination;Enrollment;Ensure;Equipment and supply inventories;Evaluation;evidence base;experience;Family member;Feedback;first episode psychosis;formative assessment;functional outcomes;Funding;implementation barriers;implementation framework;improved;improved outcome;Individual;innovation;Intervention;Maintenance;Measures;mHealth;Monitor;National Institute of Mental Health;novel;Outcome;Participant;PhenX Toolkit;poor health outcome;programs;Provider;Psychometrics;Psychoses;psychotic symptoms;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery of Function;Reference Standards;Reporting;Research;Schizophrenia;Severities;Site;sound;Standardization;support network;Symptoms;Target Populations;Technology;technology platform;Testing;Time;tool;Training;treatment choice;treatment planning;treatment program;treatment response;Universities;Validation;Work

PROJECT_TITLE: California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis (EPI-CAL)


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative / Relevance Severe psychiatric disorders cause enormous human suffering, costs, and risk of death. Although we have learned a lot about the genetic causes, we urgently need to pinpoint many more specific genes. This new knowledge will inform the development of new therapies.

PI_NAMEs: CHARNEY, ALEXANDER W (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;Americas;Asia;Biological Assay;Bipolar I;Clinical;Code;Collaborations;Consent;Contracts;cost;Data;data archive;Data Set;data sharing;Deposition;Development;Diagnosis;Diagnostic;Direct Costs;Disease;DNA;Educational process of instructing;Ethics;Etiology;Europe;exome;exome sequencing;Far East;Funding;gene discovery;Genes;Genetic;genetic architecture;Genetic Variation;genome wide association study;genomic variation;Genomics;Genotype;Human;Individual;insertion/deletion mutation;Knowledge;Learning;low income country;Major Depressive Disorder;Manic;Measures;Mental disorders;Meta-Analysis;Methods;Moon;mortality risk;National Institute of Mental Health;novel;novel therapeutics;Occupations;Output;Paper;Patients;Phase;Phenotype;Policies;Population Heterogeneity;Process;programs;psychiatric genomics;Psychiatry;Psychoses;Research;Research Personnel;Resource Sharing;risk variant;Role;Sample Size;Sampling;Schizoaffective Disorders;Schizophrenia;Science;secondary analysis;severe mental illness;severe psychiatric disorder;Severities;Site;SNP array;Technology;Therapeutic;therapy resistant;Training;Trans-Omics for Precision Medicine;Travel;Variant;Work

PROJECT_TITLE: 2/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Veteran suicide prevention has been identified as a national healthcare and research priority2. The aims of this study are to address three prominent gaps in the scientific literature. We will compare two evidence-based suicide risk interventions that vary in dose in order to a) directly test if a more intensive intervention produces greater risk reduction, b) identify veterans for whom a more intensive intervention is indicated, and c) identify resting-state and task-based neurobiological markers of future suicide attempts and examine how changes in these markers relate to changes in suicide risk over time. We will recruit and evenly randomize 136 male and female veterans hospitalized for suicide risk to an efficient or a more time-intensive intervention. We will collect neuroimaging data immediately upon discharge, post-treatment, and 12-months post-discharge and assess self-injurious thoughts and behaviors out to 12-months post-discharge.

PI_NAMEs: ESTERMAN, MICHAEL  (contact)

PROJECT_TERMS: active duty;Address;Afghanistan;Aftercare;Behavior;Belief;Brain;Cessation of life;Characteristics;Clinical;Cognition;cognitive control;cognitive task;Cognitive Therapy;comparative efficacy;Data;Decision Making;design;Dose;emotion dysregulation;emotion regulation;Emotional;evidence base;Evidence based intervention;experience;Feeling suicidal;Female;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Future;Healthcare;high risk;Hospitalization;Individual;Inpatients;Intensive Care;Intervention;Iraq;Literature;male;negative affect;neural;neurobiological mechanism;Neurobiology;neuroimaging;neuroimaging marker;novel;Outcome;Outpatients;Pattern;pharmacologic;post 9/11;Prediction of Response to Therapy;preventive intervention;Procedures;prospective;psychosocial;Randomized;Recording of previous events;recruit;reducing suicide;Research;Research Priority;Resource Allocation;Resources;response;Rest;Risk Factors;Risk Reduction;rumination;Sampling;Self Assessment;service member;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Thinking;Time;Translating;treatment as usual;treatment comparison;Treatment outcome;Veterans

PROJECT_TITLE: Suicide risk interventions: A comparison of treatment dose and neural markers of treatment outcome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBC-F (01)]


FUNDING_MECHANISM: OTHERS

PHR: Sexual minority stressors (e.g., sexual minority identity-based discrimination) contribute to greater risk for and severity of depression, anxiety, substance use disorders and suicide among sexual minority Veterans. However, no brief, scalable, one-on-one interventions targeting sexual minority stressor-related distress are available in Veterans Affairs (VA) for sexual minority Veterans. The proposed research will examine the feasibility, acceptability, and preliminary effectiveness of a brief, 3-session expressive writing intervention to target distress related to sexual minority stressor exposure among sexual minority Veterans. The results of this work will advance knowledge about a promising brief and easy to implement intervention focused on reducing depressive and anxiety symptoms among sexual minority Veterans. This proposal aligns with VA’s and CSR&D’s commitment to providing equitable services to sexual minority Veterans and the aim of reducing health disparities among underserved Veteran groups.

PI_NAMEs: HARPER, KELLY  (contact)

PROJECT_TERMS: acceptability and feasibility;active control;Activities of Daily Living;Address;Aftercare;alcohol use disorder;Alcohols;Anxiety;anxiety symptoms;Aptitude;Area;Award;biological adaptation to stress;Boston;brief intervention;career;Case Series;Clinic;Clinical;Clinical Trials;clinically significant;Communities;Consultations;coping;cost effective;depressive symptoms;Development;Diagnosis;Diagnostic and Statistical Manual of Mental Disorders;Discrimination;Dissemination and Implementation;Distress;Effectiveness;effectiveness/implementation trial;efficacy testing;efficacy trial;Emotions;Engineering;Equity;experience;Exposure to;expressive writing;Feedback;Feeling;Feeling suicidal;flexibility;Frequencies;future implementation;Goals;Hazardous Substances;Health;Healthcare;Healthcare Systems;Heterosexuals;high risk;high risk population;Hybrids;implementation facilitators;implementation intervention;implementation process;implementation science;Individual;Institute of Medicine (U.S.);Intervention;Knowledge;Lesbian Gay Bisexual;Medicine;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Military Personnel;Minority;minority stressor;Outcome;Participant;patient oriented;perceived discrimination;Pharmaceutical Preparations;post intervention;Post-Traumatic Stress Disorders;Prevalence;Procedures;Process;Productivity;Protocols documentation;Psychological Impact;Randomized, Controlled Trials;Recording of previous events;Reduce health disparities;reduce symptoms;reduced substance use;Reporting;Research;Research Personnel;Research Support;Resources;response;Risk;Sampling;satisfaction;Services;Severities;sexual minority;sexual minority health;sexual minority health research;skills;social stigma;Stress;stress reduction;Stressful Event;stressor;Structure;substance use;Substance Use Disorder;Suicide;Testing;theories;Thinking;Training;Treatment Efficacy;United States Department of Veterans Affairs;United States National Academy of Sciences;Veterans;Veterans Health Administration;Work;Writing

PROJECT_TITLE: Expressive Writing to Reduce Depressive and Anxiety Symptoms Among Sexual Minority Veterans


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI VA MEDICAL CENTER RESEARCH

ORG_STATE: OH

PHR: The origins or causes of diseases are the foundations upon which the pathological process proceeds from step to step, culminating in clinical morbidity and mortality. For systemic lupus erythematosus (SLE), extensive evidence establishes a strong relationship with Epstein-Barr virus (EBV) of uncertain relevance. We will use advanced scientific strategies to test the specific idea that SLE is caused by not only EBV, but also by the antibody generating immune response against EBV in the SLE patient. These studies, if successfully implicating EBV as a cause of SLE, would then lead the research community to re-emphasize the importance of discovering mechanisms leading from EBV to SLE. SLE has affected nearly 30,000 US Veterans with a predilection for affecting Veteran women (14 to 1 over men) and Veteran African-Americans (6.2 to 1 over European- Americans). This project, with its improved understanding of SLE origins, will ultimately bring better care and management for Veterans with this potentially deadly disease and strategies for preventing SLE all together.

PI_NAMEs: HARLEY, JOHN BARKER (contact)

PROJECT_TERMS: active duty;Affect;African American population;Age;American;Antibodies;Antibody Response;Appearance;Autoantibodies;Biological Assay;Caring;Classification;Clinical;cofactor;Communities;Competence;Cytomegalovirus;Data;Department of Defense;Diagnosis;Diagnostic;Disease;early childhood;EBV-encoded nuclear antigen 1;Epstein-Barr Virus Infections;Etiology;European;Event;expectation;experience;experimental study;Foundations;Future;gene product;Generations;Genetic Risk;Genetic Transcription;hazard;Healthcare;Human;Human Herpesvirus 4;Hypersensitivity;Immune response;Immunology;impression;improved;Individual;insight;interest;Lead;Libraries;Logistic Regressions;Medical center;men;Military Personnel;military service;Modeling;Molecular Mimicry;Morbidity - disease rate;mortality;Multiple Sclerosis;Onset of illness;Outcome;Paper;Pathogenesis;Pathologic Processes;Patients;Phage Display;pleiotropism;prevent;Preventive;Preventive measure;Probability;Process;Property;Publications;Publishing;Race;repository;Research;Resources;Risk;Risk Factors;risk variant;Role;Sample Size;Sampling;Scientific Advances and Accomplishments;Serology;Serum;service member;Services;sex;Single-Gene Defect;Systemic Lupus Erythematosus;Testing;Therapeutic;Time;Training;United States Department of Veterans Affairs;Vaccines;Veterans;virtual;Virus;Woman;Work

PROJECT_TITLE: Does Epstein-Barr Virus(EBV)Cause Systemic Lupus Erythematosus SLE)?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: The prevalence of obesity and associated co-morbidities have increased dramatically in the past several decades in both the general public and our Veterans. In addition, most people go through periods of weight gain and loss called “weight cycling”. Recently, several large studies have revealed that weight cycling increases risk of cardiometabolic disease in humans. We have generated mouse models of weight gain, weight loss, and weight cycling. Our weight cycling model recapitulates the human observation in that they are more glucose intolerant that equally obese control animals that haven't cycled. In this proposal, we seek to understand how a specific population of clonally expanded CD8+ T cells that express granzyme K impact adipose tissue function with a special focus on induction of adipocyte cellular senescence.

PI_NAMEs: HASTY, ALYSSA H (contact)

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Adoptive Transfer;age related;Aging;Animals;Area;Automobile Driving;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cell Death;Cells;Clonal Expansion;Clone Cells;comorbidity;Control Animal;cytokine;Cytoplasmic Granules;Cytotoxic T-Lymphocytes;Data;Defect;Diabetes Mellitus;Disease;exhaust;Family;Fibroblasts;Functional disorder;Future;General Population;Genes;Glean;Glucose;Glucose Intolerance;glucose tolerance;Granzyme;Health;Human;Immune;Immunologic Memory;Immunologics;Immunology;Immunophenotyping;Impairment;improved;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin secretion;interest;Knockout Mice;Knowledge;Link;lipid biosynthesis;Liver;Malignant Neoplasms;member;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;Modeling;mouse model;Mus;Muscle;Names;new therapeutic target;novel;Obese Mice;obese person;Obesity;old mice;Oxidative Stress;Pancreas;Peripheral;Persons;Phenotype;Population;Premature aging syndrome;Prevalence;Production;Publishing;Reporting;Research;Residual state;Risk;Role;senescence;Serine Protease;single-cell RNA sequencing;T-Lymphocyte;Thinness;Tissues;Veterans;Weight;Weight Gain;Work

PROJECT_TITLE: Immunological Memory of Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDA-L (01)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Traumatic brain injury (TBI) is a significant problem amongst Veterans and many US citizens with few effective treatments. Inflammation following TBI is thought to worsen damage due to non specific immune reactions causing injury to adjacent healthy brain tissue. Work from our group has focused on these immune reactions, and how they might be modulated to lead to improved neurological outcomes from brain trauma. Recently, we have studied a molecule known as the calcium-release- activated calcium (CRAC) channel, which is involved in initiating immune responses. In collaboration with biotechnology company CalciMedica, Inc, we tested a novel inhibitor of the CRAC channel in a model of experimental TBI and found that it also improved neurological outcomes. Here, we hope to further refine the extent of the benefit of this inhibitor in order to determine whether this approach could be studied in humans with brain injury.

PI_NAMEs: YENARI, MIDORI A (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Acute Brain Injuries;acute COVID-19;acute pancreatitis;Affect;Animals;Area;Autoimmune Diseases;Binding;Biological Assay;Biotechnology;Brain;Brain Injuries;brain tissue;Calcineurin;Calcineurin inhibitor;Calcineurin Pathway;Calcium;Calcium Channel;Cells;Clinical;cohort;Collaborations;COVID-19 pneumonia;Cyclosporine;Cytoprotection;Dose;effective therapy;Experimental Models;experimental study;Female;FK506;glial activation;Hour;Human;Immune;Immune response;Immune signaling;immunoreaction;Immunosuppression;improved;improved outcome;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;knock-down;Laboratories;Length;male;mast cell;Mediating;men;Microglia;Modeling;Mus;Nervous System Trauma;Neurologic;Neurological outcome;neuroprotection;neutrophil;novel;Outcome;Pathway interactions;patient population;Plasma;Population;prevent;Publishing;Pulmonary Inflammation;Regimen;Regulation;response;Role;severe COVID-19;side effect;Signal Transduction;Site;small molecule inhibitor;Source;Specificity;Stroke;stroke model;T-Lymphocyte;Tacrolimus;Testing;Therapeutic;therapeutic target;Toxic effect;Translations;Traumatic Brain Injury;Up-Regulation;Veterans;Virus;Woman;Women's study;Work

PROJECT_TITLE: Calcium release-activated calcium (CRAC) channels in experimental traumatic brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURC-C (01)]


ORG_CITY: KANSAS CITY

ORG_NAME: KANSAS CITY VA MEDICAL CENTER

ORG_STATE: MO

PHR: The proposed research is relevant to vaterans health in developing a tumor-tergated pH/Hypoxia responsive nanoparticles (pHNPs) for inhibiting a downstream target of mutant K-Ras, extracellular receptor kinase (ERK) in pancreatic ductal adenocarcinoma (PDAC), thereby halting the progression of the disease and sensitize the chemotherapy with the minimized possibility of off-target side effects. The outcome of the proposed research will fulfill a part of the VA drug discovery mission of undertaking fundamental research, which will be applicable in treating human diseases.

PI_NAMEs: BANERJEE, SUSHANTA K. (contact)

PROJECT_TERMS: Acute;Binding;Biological Availability;Biological Markers;Cancer Cell Growth;Cell Line;Cell Survival;Cells;Chemoresistance;chemotherapy;Clinic;Clinical Trials;Combined Modality Therapy;connective tissue growth factor;Data;design;Desmoplastic;Development;Disease;disease prognosis;Disease Progression;Dose;Dose Limiting;Drug Carriers;drug discovery;Drug Exposure;Drug Kinetics;drug resistance development;Encapsulated;epithelial to mesenchymal transition;experience;experimental study;extracellular;Extracellular Matrix;Extracellular Signal Regulated Kinases;Female;Fibroblasts;Folic Acid;frontier;fundamental research;gemcitabine;Genetically Engineered Mouse;Goals;Growth;Growth Factor;Health;high resolution imaging;Human;human disease;Hypoxia;Immunotherapy;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;Intraperitoneal Injections;Investigational New Drug Application;JUN gene;kinase inhibitor;Knowledge;KRAS2 gene;Legal patent;male;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mission;Modeling;molecular marker;Molecular Target;mouse model;multidisciplinary;Mus;mutant;nanocarrier;nanoencapsulated;nanoparticle;Napping;Neoplasm Metastasis;novel therapeutics;Nude Mice;optimal treatments;Outcome;overexpression;Paclitaxel;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathologic;patient derived xenograft model;patient subsets;Patients;Penetration;Peptides;Pharmaceutical Preparations;Pharmacy (field);Phenotype;Phosphotransferases;Plasma;Polyethylene Glycols;Polymers;pre-clinical;preclinical evaluation;Process;Production;Prognosis;prognostic;promoter;Proteins;Ras Signaling Pathway;receptor;Research;response;Risk;Role;Sampling;side effect;Signal Transduction;Standardization;stemness;Stimulus;Technology;Testing;Therapeutic;Time;tissue biomarkers;Tissues;Toxic effect;Transcription Factor AP-1;Translating;translational study;Treatment Efficacy;Treatment Protocols;treatment strategy;tumor;tumor growth;tumor progression;tumor xenograft;Variant;Veterans;Xenograft Model

PROJECT_TITLE: ERK-Signaling in Microenvironment of Pancreatic cancer: Development of NovelTherapeutic Hypoxia-Responsive Nano-encapsulated ERK inhibitor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  The goal of this proposal is to establish clinical brain tumor perfusion imaging protocols and analysis tools strategically designed for high accuracy, physiologic sensitivity and clinical applicability. Such tools could improve the reliability and relevancy of perfusion imaging protocols across a range of clinical scenarios, including tumor localization, therapy response assessment, surgical and biopsy guidance, and multi-site clinical trials of conventional and targeted brain tumor therapies.

PI_NAMEs: QUARLES, CHRISTOPHER CHAD (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Aftercare;Algorithms;anatomic imaging;Anatomy;arm;Benchmarking;Biopsy;Brain Neoplasms;brain tumor imaging;Clinical;clinical application;clinical practice;Clinical Trials;clinically relevant;Communities;Computer software;Consensus;contrast enhanced;Contrast Media;Data;design;Differential Diagnosis;digital;Dose;Dropout;Echo-Planar Imaging;Europe;Exhibits;Functional Imaging;Funding;Future;Glioblastoma;Glioma;Goals;Healthcare;Image;Imaging Techniques;improved;Magnetic Resonance Imaging;Manuscripts;Maps;Measures;Methods;Morphologic artifacts;Multi-Institutional Clinical Trial;neuro-oncology;Operative Surgical Procedures;Patients;Perfusion;perfusion imaging;Physiologic pulse;Physiological;Population;population based;Predisposition;prognostic;Property;prospective;Protocols documentation;radiation effect;Radiation necrosis;Recommendation;reconstruction;Recurrence;Recurrent tumor;Reporting;Reproducibility;response;Scanning;Signal Transduction;Site;Slide;success;targeted treatment;Techniques;Tissues;tool;treatment effect;treatment response;tumor;Validation;Work

PROJECT_TITLE: Establishing the Validity of Brain Tumor Perfusion Imaging


ADMINISTERING_IC: MD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Inequities faced by Black, Latinx, and Indigenous populations—from infant deaths to ovarian cancer to Covid- 19 infection—have barely decreased, despite huge investments to address them. Healthcare and government organizations are more often recognizing that those inequities are rooted in the conditions in which we live, grow, work, and learn. However, little consideration has been given to the role of structural racism. This study will create a tool to understand the effects of structural racism on neighborhoods in the US to help policymakers and healthcare leaders decide how and where resources should be invested. 1

PI_NAMEs: DYER, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;American;Area;Attention;Automobile Driving;Awareness;Black American;Black Populations;Black race;built environment;burden of illness;caucasian American;Censuses;Child Health;Communities;cost;COVID-19 pandemic;Criminal Justice;Data;Decision Making;Discrimination;Education;Employment;Face;Federal Government;Geography;Government;Health;Health Care Costs;health care service utilization;health data;health determinants;health disparity;health equity;health inequalities;Health Insurance;health plan;Health system;Healthcare;Hospital Planning;Housing;improved;indexing;Individual;individual patient;Inequity;Infant;Infant Mortality;insight;Institution;Intervention;Investments;Latinx;Latinx population;Learning;Life Expectancy;Local Government;Malignant neoplasm of ovary;Massachusetts;Measures;Medicaid;Medicare/Medicaid;member;mortality;National Institute on Minority Health and Health Disparities;Native-Born;Neighborhoods;novel;nutrition;Outcome;Patient Self-Report;payment;Performance;Policies;policy implication;Policy Maker;poor health outcome;Population;Poverty;Prevalence;Prevention;programs;Public Health;Resources;Role;SARS-CoV-2 infection;social;social cohesion;social determinants;social health determinants;State Government;structural health determinants;Structural Racism;supported housing;System;Taxes;Testing;tool;Transportation;United States National Institutes of Health;waiver;Work

PROJECT_TITLE: Outlining Shadows of Structural Racism Using Publicly Available Social Determinants of Health Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Presynaptic group III metabotropic glutamate receptors (mGluR) sense glutamate release from synapses and inhibit further release in order to maintain glutamate homeostasis. This project will investigate how mGluR activity is allosterically regulated by interactions with a family of cell adhesion proteins called ELFN proteins.

PI_NAMEs: LUDLAM, WILLIAM GRANT (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Autoreceptors;Binding;Biological Assay;Brain;Cell Adhesion Molecules;Cells;Cognitive;Complex;Coupled;crosslink;Cryoelectron Microscopy;Deuterium;Dimerization;Disease;Environment;Epilepsy;Epitopes;experimental study;Exposure to;extracellular;Family;Feedback;Fibronectins;Foundations;G-Protein-Coupled Receptors;Glutamates;grasp;Homeostasis;Homo;Hormones;Hydrogen;Hyperactivity;In Vitro;Individual;insight;Knock-out;Leucine-Rich Repeat;Mass Spectrum Analysis;Measures;Membrane;Metabotropic Glutamate Receptors;Modeling;Molecular;Motor;Movement Disorders;Mus;Mutation;Neurons;Neurotransmitters;Parkinson Disease;Pathology;Physiological;Physiology;Positioning Attribute;Post-Traumatic Stress Disorders;postsynaptic;presynaptic;Proteins;receptor;receptor binding;Receptor Signaling;reconstitution;Regulation;Resolution;Role;Seizures;Signal Transduction;Stimulus;Structural Models;Structure;Synapses;Testing;therapy design

PROJECT_TITLE: Elucidating transsynaptic regulation of metabotropic glutamate receptors

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: MEMPHIS

ORG_NAME: MEMPHIS VA MEDICAL CENTER

PHR: Obesity is very prevalent in America today and occurs in 40% of our Veterans. Obesity worsens many aspects of cardiovascular disease by increasing insulin resistance, hyperlipidemia and atherosclerosis. One strategy for promoting weight loss is to increase energy expenditure by activating brown adipose tissue. Brown adipose tissue metabolizes fat to generate heat rather than usable energy. We have discovered a secretory phospholipase that activates brown adipose tissue. We propose to further define the novel role of this phospholipase. We will discover the mechanisms underlying the activation of brown adipose tissue and determine how this secretory phospholipase improves insulin sensitivity. Answering these questions will suggest strategies for altering adipose tissue metabolism and improving insulin responsiveness. These are issues directly related to type 2 diabetes and obesity, two common concerns of Veterans health. 1

PI_NAMEs: PARK, EDWARDS A (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adsorption;Aging;Anti-Bacterial Agents;Atherosclerosis;Bacterial Infections;Basic Science;Body Weight decreased;Brown Fat;C57BL/6 Mouse;Calcium;Cardiovascular Diseases;Cardiovascular system;Classification;Clinical;clinically relevant;Complications of Diabetes Mellitus;cytokine;Data;Diabetes Mellitus;diet-induced obesity;Disease Resistance;Eicosanoids;Elements;Energy Metabolism;Enzymes;Exons;Family;Family member;Fatty acid glycerol esters;Fatty Acids;Frameshift Mutation;Gene Expression;Gene Expression Profile;Genes;Glucocorticoids;glucose tolerance;Glycerophospholipids;Health;High Fat Diet;Hormones;Human;Hyperlipidemia;improved;Inbred BALB C Mice;Inflammation;Inflammatory Response;insight;Insulin;Insulin Resistance;insulin sensitivity;Intestines;Investigation;Knock-out;knockout gene;Laboratories;Link;lipid mediator;lipidomics;Lipids;Lysophospholipids;Mediating;Medical;member;Membrane;Metabolic;Metabolic Activation;Metabolic Diseases;metabolic rate;Metabolic syndrome;Metabolism;military veteran;Mitochondria;mitochondrial metabolism;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Nuclear;Obesity;oxidized low density lipoprotein;Pathologic Processes;Patients;Phosphatidylethanolamine;Phosphatidylserines;Phospholipase;Phospholipase A2;Phospholipids;Phosphotransferases;Physiological Processes;PLA2G2A gene;Positioning Attribute;Protein Isoforms;Proteins;Regulatory Pathway;Resistance;Risk Factors;Role;Signal Transduction;Signaling Molecule;Stroke;Testing;Therapeutic Intervention;Tissues;uncoupling protein 1;usability;Veterans;Weight Gain;Work

PROJECT_TITLE: Secretory phospholipase A2 enhances metabolic rate


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Alzheimer's disease (AD) is the major cause of devastating late-life dementia and currently there are no effective treatments to stop its progression. In this project, we seek to understand the mechanisms that regulate the multifaceted actions of amyloid beta peptides in disrupting neuronal function and cognitive behavior. If successful, this study would advance our fundamental understanding of the complex cognitive heterogeneity of this multifactorial disorder and lead to a new direction for its treatment.

PI_NAMEs: WANG, QIN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;abeta oligomer;Address;Adrenergic Agonists;Adrenergic Receptor;Affinity;Agonist;Allosteric Site;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;Autopsy;Behavior;Binding;Biological Factors;Brain;Cause of Death;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cohort;comparison control;Complex;Coupling;CRISPR/Cas technology;Data;Databases;Dementia;Disease;Disease Progression;effective therapy;Environmental Risk Factor;epidemiology study;extracellular;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;genetic approach;glycogen synthase kinase 3 beta;GTP-Binding Proteins;Heterogeneity;Human;Impaired cognition;Impairment;improved;In Vitro;in vivo;late life;Ligands;Mediating;Mediator;Molecular;Molecular Conformation;monomer;Morphology;Multiprotein Complexes;Mus;mutant;nanomolar;Neuronal Dysfunction;Neurons;new therapeutic target;novel;Pathologic;Pathology;Patients;Phosphoric Monoester Hydrolases;prevent;Process;Protein Dephosphorylation;Protein phosphatase;receptor;receptor density;Receptor Signaling;Role;Severities;Signal Transduction;Synapses;System;tau Proteins;tau-1;Techniques;Testing;therapeutic target;Toxic effect;Vertebral column;Viral;Virulence Factors

PROJECT_TITLE: Beta amyloid-adrenergic receptor interaction in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-M]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_DEPT: NUTRITION

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The proposed study is a 10- to 15-year post-trial observational follow-up of CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy), the first randomized controlled trial of calorie restriction (CR) in humans. The CALERIE trial demonstrated that 2 years of CR leads to significant improvements in markers of healthspan and an attenuated rate of biological aging compared to ad libitum intake. With a goal of informing public health strategies that promote healthy aging, the proposed study will examine the legacy effects of the CALERIE trial to determine the effectiveness of CR exposure in early to mid- adulthood in reducing the rate of biological aging and the risk of age-related chronic disease.

PI_NAMEs: DAS, SAI KRUPA  (contact);RACETTE, SUSAN BETH;REDMAN, LEANNE MAREE

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Address;Adult;Aerobic;Age;age related chronic disease;age-related disease;Aging;aging biomarker;aging process;Algorithms;Attenuated;Baltimore;Basal metabolic rate;behavior change;biobehavior;Biological;biological age;Biological Aging;Biological Markers;Biological Specimen Banks;Blood;blood-based biomarker;Body Composition;Body measure procedure;Brain natriuretic peptide;C-reactive protein;Caloric Restriction;Cardiometabolic Disease;cardiorespiratory fitness;Cell Aging;Clinical Trials;Cognition;cognitive function;cohort;Communities;comparison group;Control Groups;data repository;design;Development;diet and exercise;disorder risk;effectiveness evaluation;energy efficiency;Energy Intake;experience;Exposure to;Fatigue;follow-up;Follow-Up Studies;Funding;Gait speed;GDF15 gene;General Population;geroprotector;Glycosylated hemoglobin A;Goals;Hand Strength;healthspan;healthy aging;Human;improved;indexing;Insulin;Insulin-Like Growth Factor I;Intake;Interleukin-6;Intervention;Isoprostanes;lifestyle intervention;Long-Term Effects;Longitudinal Studies;Measurement;Measures;Metabolic syndrome;Metformin;Methods;middle age;model organism;motivated behavior;N-terminal;National Institute on Aging;novel;Nutritional;Obesity;Observational Study;Outcome;Oxidative Stress;Participant;Pattern;Phenotype;post gamma-globulins;prevent;primary outcome;pro-brain natriuretic peptide (1-76);Proteins;psychologic;Public Health;Quality Control;Quality of life;Randomized, Controlled Trials;rate of aging;Risk;Sampling;senescence associated secretory phenotype;Sleep;Testing;TNFRSF1A gene;urinary;Urine;VO2max

PROJECT_TITLE: Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BRISBANE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF QUEENSLAND

PHR: PA-19-077 DOOLAN: NARRATIVE This proposal is targeting the development of a malaria vaccine that induces robust and protective T cell responses against the liver stage of the Plasmodium parasite. From the complete P. falciparum pre-erythrocytic (sporozoite/liver) stage proteome, we will identify, characterize, and credential priority antigens discovered by proteome-based T cell screening; and will progress protective antigens through preclinical development to provide a vaccine candidate capable of inducing robust and sustained protective immunity against malaria.

PI_NAMEs: DOOLAN, DENISE L. (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: adaptive immunity;Address;Adenoviruses;Agonist;Antibodies;Antibody Response;Antigen Targeting;Antigens;Attenuated;Categories;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;Characteristics;Chemoprophylaxis;Chloroquine;Clinical;clinical development;clinically relevant;combinatorial;Complex;Computational Science;Conserved Sequence;Credentialing;Data;data integration;Data Set;design;Development;Disease;DNA;Erythrocytes;Genome;Goals;Human;human data;human model;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunology;In complete remission;in silico;in vivo;Individual;Infection;innovation;Intravenous;Lead;Link;Liposomes;Liver;Malaria;Malaria Vaccines;Mediating;Mediator;Memory;Messenger RNA;Multiomic Data;Mus;Natural Immunity;next generation;novel;novel strategies;Outcome;Parasites;pathogen;Phase;Plasmodium;Plasmodium falciparum;Populations at Risk;Pre-Clinical Model;preclinical development;prevent;Proteins;Proteome;Public Health;public health priorities;Radiation;rational design;Regimen;research clinical testing;response;Risk;RNA vaccine;screening;Selection Criteria;Site;Sporozoites;Sterility;synergism;T cell response;T-Lymphocyte;Targeted Research;Technology;tissue resident memory T cell;Tissues;Transcend;translational research program;transmission process;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;vaccine delivery;vaccine development;vaccine evaluation;vaccine platform;Vaccines;vaccinology;Virulent

PROJECT_TITLE: Human-informed data-driven development of next-generation T cell vaccine against malaria

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE Screening mammography reduces breast cancer mortality, but can also result in over-diagnosis and over- treatment. Improved breast cancer risk prediction models can enable personalized screening tailored to each woman's risk, and thereby maximize the benefits and minimize the harms of screening. Our study will examine whether breast tissue features automatically extracted from mammograms (radiomics) and polygenic risk scores can significantly improve upon current clinical breast cancer risk prediction models among ethnically diverse women undergoing screening mammography in two large community health settings. 1

PI_NAMEs: HABEL, LAUREL A;SHEN, LI ;SIEH, WEIVA  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: 3-Dimensional;Adoption;Age;Algorithms;Architecture;Breast Cancer Detection;Breast Cancer Model;Breast Cancer Risk Factor;California;Cancer Detection;Cancer Etiology;cancer risk;cancer subtypes;Categories;Cessation of life;Characteristics;Clinical;clinical risk;cohort;Community Health;cost;Costs and Benefits;Data;deep learning;deep learning algorithm;deep learning model;density;Development;Diagnosis;Digital Breast Tomosynthesis;Digital Mammography;Discrimination;Early Diagnosis;Electronic Health Record;Enrollment;Environment;ethnic diversity;Ethnic Origin;Family;Future;General Population;Genes;genome wide association study;genome-wide;genomic predictors;Genomics;Harm Reduction;Health;Health Care Costs;health care settings;Health system;high risk;High Risk Woman;improved;Individual;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Mining;Modeling;Modification;mortality;multi-ethnic;New York;overtreatment;Performance;personalized screening;polygenic risk score;Population;population based;Population Heterogeneity;prediction algorithm;programs;Race;racial difference;radiomics;Recording of previous events;Regimen;Research;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;screening;screening guidelines;Surveys;Susceptibility Gene;System;Technology;Tissues;tomosynthesis;tool;Woman

PROJECT_TITLE: Radiomic and genomic predictors of breast cancer risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: Nearly half of trans women in New Orleans, Louisiana are living with HIV and many face extreme stigma creating high risk environments and limiting access to life-saving HIV prevention. The proposed intervention is a combination of novel trans-specific pilot components developed by experienced investigators to support PrEP awareness, uptake and adherence among trans women in New Orleans, Louisiana. The proposed line of research has the potential to fill a large gap in PrEP interventions for trans women in the U.S. South where extraordinary HIV and PrEP disparities exist.

PI_NAMEs: BARAK, NARQUIS ;MEEK, ERIN CATHERINE (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adherence;AIDS prevention;Annual Reports;Awareness;Bisexual;Black race;Caring;Charge;cis-male;Clinic;Communities;community advisory board;community clinic;community engagement;Cost efficiency;Cross-Over Studies;Data;Deep South;design;digital;digital intervention;Disparity;Ecological momentary assessment;Effectiveness;empowerment;Environment;evidence base;Evidence based intervention;Exclusion;experience;Face;Gays;Goals;Health;Health Services Accessibility;Healthcare;Hearing;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV/STD;improved;innovation;Intervention;Investments;Letters;Life;Louisiana;Measures;Media Campaign;Mediating;member;men;Methods;mHealth;Modeling;motivational enhancement therapy;novel;Outcome;Participant;peer;Persons;pilot test;Population;population based;Population Study;pre-exposure prophylaxis;prevention service;psychological distress;racial diversity;Randomized;recruit;Reporting;Research;Research Design;Research Personnel;response;Running;Sampling;San Francisco;social health determinants;social media;social stigma;substance use;surveillance data;surveillance study;Testing;Text;therapy design;Time;transgender;transgender women;Trust;uptake;Viral;web site;Woman;Work

PROJECT_TITLE: Tcher, Take Charge: Increasing PrEP Awareness, Uptake, and Adherence Through Health Care Empowerment and Addressing Social Determinants of Health Among Racially Diverse Trans Women in the Deep South


PHR: Type 2 diabetes (T2D) is a disease that affects nearly one quarter of our nation's Veterans and is a growing challenge to the VA healthcare system. Although the causes of T2D are poorly understood, dysfunctional secretion of insulin and glucagon by pancreatic islet beta and alpha cells, respectively, is a key component. While much emphasis has been placed on studying beta cell biology, very little is known about the mechanisms controlling alpha cells in health or in diabetes. Decreased levels of islet-enriched nuclear factors may contribute to islet dysfunction in T2D. In this grant, we will investigate how loss of one such factor, MAFB, affects the function of human alpha cells. In addition, we will broadly define how alpha cell activity and health are compromised under insulin resistant conditions that mimic the metabolic environment of T2D. We will use new technologies and experimental approaches coupled to in vitro and in vivo analyses to discover physiologic and genetic mechanisms controlling human alpha cell activity in healthy and diseased pancreatic islets.

PI_NAMEs: COATE, KATHRYN COLBERT (contact)

PROJECT_TERMS: Acute;Address;Adult;Affect;Alpha Cell;Basic Science;Beta Cell;Bioinformatics;Biology;blood glucose regulation;Candidate Disease Gene;Cell Physiology;Cells;Cellular biology;Chromatin;Chronic;Chronic Disease;clinically actionable;collaborative environment;Coupled;detection of nutrient;Developmental Biology;Diabetes Mellitus;diabetes pathogenesis;Disease;Down-Regulation;Electron Microscopy;endocrine pancreas development;Environment;Evaluation;Exocytosis;expectation;Expenditure;experimental study;Exposure to;Fatty acid glycerol esters;Foundations;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene function;Genetic;genetic manipulation;Genetic study;Genetic Transcription;Glucagon;Glucose;Glucose Intolerance;Grant;Health;Healthcare Systems;High Fat Diet;Hormonal;Hormone secretion;Human;human embryonic stem cell;Hyperglycemia;Immunocompromised Host;Impairment;improved;In Vitro;in vivo;in vivo evaluation;innovation;insight;Insulin;Insulin Resistance;insulin secretion;International;Ion Channel;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;K-Series Research Career Programs;knock-down;Knock-out;Knockout Mice;Knowledge;Lead;lentiviral-mediated;Link;lipid metabolism;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Diseases;Modeling;Molecular;mouse model;Mus;new technology;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Obesity;Oxidative Stress;Pancreatic Diseases;pancreatic juice;Pathologic;Pathology;patient population;Pattern;Physiological;Population;postnatal;Prevalence;Production;programs;Publishing;Research;Research Personnel;response;Rodent;Role;Services;single-cell RNA sequencing;small hairpin RNA;stressor;Structure;System;Teacher Professional Development;Techniques;Testing;Time;tool;Training;transcription factor;transcriptomics;Transplantation;Transplantation Tolerance;type I and type II diabetes;United States Department of Veterans Affairs;Veterans;virtual;Xenograft procedure

PROJECT_TITLE: Pancreatic islet alpha cell response to insulin resistance and type 2 diabetes


ORG_CITY: MILWAUKEE

ORG_NAME: CLEMENT J. ZABLOCKI VA MEDICAL CENTER

ORG_STATE: WI

PHR: Spinal cord injury (SCI) is a severe condition with a strong impact on neurological function and overall health of affected persons, including our active and veteran military population, especially since soldiers in combat situations are at high risk for SCI. Depending on the level of the injury and extent of the tissue damage, SCI causes a broad range of symptoms. The initial tissue damage in the spinal cord tissue is caused by the mechanical impact, but then significantly enlarged by a cascade of reactions, including inflammation in the spinal cord. Messenger factors, so called cytokines, are important regulators of the inflammatory response. We have previously shown that the cytokine IL-12 mediates tissue damage and impairs recovery in a model of SCI. The goal of this project is to decipher how this damage is caused and to specifically inhibit this process without interfering with the overall immune response. Successful completion of this preclinical study could result in new targeted drug therapies to improve functional outcomes and quality of life after SCI.

PI_NAMEs: SWARTZ, KARIN  (contact)

PROJECT_TERMS: Address;Affect;Astrocytes;Autonomic Dysfunction;cell type;Cells;combat zone;comparison control;Cre lox recombination system;cytokine;cytotoxic;cytotoxicity;Data;design;Development;Down-Regulation;Early treatment;effective therapy;efficacy evaluation;Functional impairment;functional improvement;Future;Genes;Goals;Health;Health Benefit;high risk;Histology;IL12RB2 gene;Immune response;immunoreaction;immunosuppressed;Immunosuppression;Impairment;improved;Incidence;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;inhibitor;Injury;insight;Interleukin-12;interleukin-12 receptor;interleukin-23;Interruption;Intervention;Laboratories;Life;Locomotor Recovery;Mechanics;Mediating;Mediator;Microglia;Military Personnel;military veteran;Modeling;Modernization;Mus;Nervous System Physiology;neuroprotection;new therapeutic target;novel therapeutic intervention;Pathogenicity;Pathway interactions;Peripheral;Persons;Pneumonia;Population;preclinical study;preservation;Process;Proteins;Quality of life;Reaction;receptor;receptor expression;Recovery;Recovery of Function;Risk;RNA;Role;Secondary to;severe injury;Signal Transduction;Signaling Molecule;Site;small hairpin RNA;Soldier;Specificity;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spinal Injections;STAT1 gene;STAT4 gene;Symptoms;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thoracic spinal cord structure;Tissue Expansion;Tissue Preservation;Tissues;transcription factor;transcriptomics;Trauma;Veterans

PROJECT_TITLE: Role of the pro-inflammatory cytokines IL-12 and IL-23 in secondary damage after spinal cord injury


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PI_NAMEs: SU, LAURA  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adult;Affinity;Age;Antibodies;Antibody Formation;Antibody Response;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmunity;Automobile Driving;B-Lymphocytes;Bacteria;Binding;Blood specimen;CD4 Positive T Lymphocytes;Cells;commensal bacteria;Communities;COVID-19;COVID-19 impact;cross reactivity;Data;Development;Disease;Environment;experimental study;Exposure to;Frequencies;General Population;Health;Healthcare;Homeostasis;Human;Immune;Immune response;Impairment;Individual;Infection;Inflammation;insight;Intestinal permeability;joint destruction;Knowledge;Libraries;Link;Memory;Microbe;microbial;microbiome;microbiota;Modeling;Mus;novel;pathogen;Patients;Persons;Population;post SARS-CoV-2 infection;post-COVID-19;pre-pandemic;Production;Proteins;recruit;Research;response;Rheumatoid Arthritis;SARS-CoV-2 infection;Self Tolerance;Surface;T cell response;T-cell diversity;T-Lymphocyte;Testing;United States;United States Department of Veterans Affairs;Veterans

PROJECT_TITLE: Defining how microbes drive abnormal T Cell responses in rheumatoid arthritis


PHR: Our veterans have frequently been exposed to UV light as part of their service in the military, This is a high incidence of both photoaging, skin inflammation, and skin cancer in this population, Understanding the causes of photoaging and skin inflammation will help to better manage the reactions seen frequently in the skin of veterans, It is clear that extracellular vesicles play a critical role in photoaging and skin inflammation in vitro and in vivo, Better understanding of the molecular mechanisms (including crosstalk between different pathways and effects) will help develop a potential therapeutic strategy to protect against these conditions associated with UVB exposure, Project Narrative

PI_NAMEs: JOHNSON, RUDOLPH C;WERTH, VICTORIA P (contact)

PROJECT_TERMS: absorption;Cell Communication;cell type;Cells;Data;Dermal;Dermis;ds-DNA;Epidermis;extracellular vesicles;Fibroblasts;Generations;Immune;Immune Targeting;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;inhibitor;Integrins;intradermal injection;irradiation;keratinocyte;Lipid Bilayers;Lipids;Mediating;Mediator;Medical;Melatonin;Membrane;Military Personnel;Molecular;Mus;NF-kappa B;novel;novel therapeutic intervention;Nucleic Acids;Pathway interactions;prevent;Production;Proteins;recruit;response;Role;Signal Transduction;Skin;Stimulator of Interferon Genes;System;Testing;Therapeutic;Ultraviolet B Radiation;UVB induced;Veterans

PROJECT_TITLE: Extracellular vesicles as a novel mediator for ultraviolet-B light induced photoaging and skin inflammation.


PHR: Prostate cancer accounts for nearly one-third of all cancer diagnoses amongst men in the VA patient population, and a percentage of prostate cancer patients will develop bone metastatic cancers, which remain incurable. Current standard-of-care treatment options for bone-metastatic prostate cancer improve overall survival by a modest four months, highlighting a need for more efficacious therapies. Adoptive transfer of engineered immune cells has led to decade-long remissions in adult and pediatric patients with B cell leukemia and a phase I clinical trial of engineered immune cells in patients with metastatic castrate-resistant prostate cancer (mCRPC) demonstrated feasibility and promise. In the proposed research, we aim to develop engineered immune cells capable of overcoming adaptive resistance mechanisms of prostate cancer, including targeting multiple antigens simultaneously, negating immunosuppressive signaling, and synergizing orthogonal mechanisms of immune engagement and cytolysis to improve treatment options for veterans with prostate cancer.

PI_NAMEs: POSEY, AVERY D. (contact)

PROJECT_TERMS: Adoptive Transfer;Adult;Advanced Development;Agonist;Androgen Antagonists;androgen independent prostate cancer;anti-PD-1;Antigen Presentation;Antigen Targeting;Antigens;Antitumor Response;Autologous;B-Cell Leukemia;Binding;bone;cancer diagnosis;Cancer Etiology;Cancer Patient;CAR T cell therapy;Cell surface;Cell Therapy;Cells;Cellular immunotherapy;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Cytolysis;Cytotoxic T-Lymphocytes;desensitization;design;Development;Disease remission;Effectiveness;efficacious treatment;engineered T cells;Engineering;Exhibits;Extracellular Matrix;Failure;Fibronectins;Generations;Goals;Hematologic Neoplasms;Heterogeneity;Immune;immune activation;Immune checkpoint inhibitor;Immunity;immunoengineering;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;interest;Interferon Type II;Interferons;Malignant neoplasm of prostate;Mediating;Mediator;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Microsatellite Instability;Mismatch Repair Deficiency;Molecular;Mucin 1 protein;Mutation;neoplastic cell;next generation;Nonmetastatic;novel;patient population;Patients;pediatric patients;Peptide/MHC Complex;Phase I Clinical Trials;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Prostate Cancer therapy;Provenge;Rejuvenation;Research;resilience;Resistance;resistance mechanism;response;Signal Transduction;Solid Neoplasm;standard of care;Surface;Survival Rate;synergism;targeted treatment;TLR2 gene;TLR4 gene;TNF gene;tool;Treatment Efficacy;tumor;Tumor Antigens;Tumor Escape;tumor microenvironment;United States;Veterans

PROJECT_TITLE: Optimizing Cell Therapy to Counter Adaptive Resistance Mechanisms in Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCA-S (01)]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: This project aims to improve the identification of high-risk Veterans and decrease suicidal behavior through enhanced and evidence-based screening methods and through individualized risk assessments based on demographic, clinical, and genetic risk factors. Risk factors identified through this study would be important to include as part of routine suicide prevention efforts, and the genetic risk factors identified through this study could be incorporated into comprehensive medical treatment plans. If successful, early detection of Veterans at greater risk for suicidal behavior will allow for early intervention and lower rates of suicide attempt and death.

PI_NAMEs: WILLOUR, VIRGINIA L (contact)

PROJECT_TERMS: Age;Algorithm Design;Algorithms;Anxiety;base;Biological;Bipolar Disorder;Chromosome 7;Clinical;Clinical assessments;clinical risk;cohort;Collection;comorbidity;cooperative study;Data;Data Set;Diagnosis;Disease;DNA;Early Diagnosis;Early Intervention;Electronic Health Record;epidemiology study;Ethnic Origin;evidence base;Female;Genetic;Genetic Load;Genetic Risk;genetic risk factor;genome wide association study;Genotype;Heritability;high risk;high risk population;improved;Individual;interest;International;Interview;Machine Learning;machine learning algorithm;Medical;Mental disorders;Methods;Mood Disorders;Phenotype;phenotypic data;polygenic risk score;Post-Traumatic Stress Disorders;predictive modeling;programs;Public Health;Race;Research Personnel;Risk Assessment;Risk Factors;Sampling;screening;severe mental illness;Severities;sex;Signal Transduction;Structure;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Test Result;Testing;Training;treatment planning;Utah;Validation;Veterans;Woman;Work

PROJECT_TITLE: Identification of Demographic, Clinical, and Genetic profiles for Suicidal Behavior in US Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-T (01)]


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Neuropathic pain after nerve trauma is a devastating event that affects younger Veterans, often on the battlefield, and is associated with long-term disability and the potential for opioid addiction. Within minutes after nerve injury, there is a robust inflammatory response characterized by the release of pro-inflammatory mediators from specialized cells in the spinal cord and the periphery. These mediators initiate neuropathic pain through the hyperexcitation of pain-propagating nerve cells which then ultimately leads to chronic pain. This proposal will investigate SRI-42127, a novel drug that inhibits HuR, a key protein which drives the production of inflammatory mediators linked to neuropathic pain. This molecule can be given peripherally (e.g. on the battlefield) and it quickly suppresses the induction of these pain-producing inflammatory mediators and mitigates the genesis of NP. This research proposal is therefore directly relevant to Veteran health and has the potential to improve quality of life for those who suffer from injury-induced neuropathic pain.

PI_NAMEs: KING, PETER H (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acute;Address;Adenine;Affect;allodynia;Area;Attention;Attenuated;attenuation;Behavior assessment;behavior test;Behavioral;Binding;CCL2 gene;cell type;Cells;Chemicals;chemokine;Chronic;Chronic disability;chronic pain;Chronic Phase;Clinic;Clinical;conditional knockout;CXCL1 gene;cytokine;Cytoplasm;Data;Development;Dimerization;Dose;Elements;Event;Female;Flow Cytometry;Genetic;glial activation;Goals;Health;Immune;immune activation;Immune Cell Suppression;Immunohistochemistry;improved;Individual;Infiltration;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Injury;innovation;insight;Interleukin-1 beta;Interleukin-6;Invaded;Investigation;Knock-out;Knockout Mice;Laboratories;Link;Long term disability;Longevity;Lumbar spinal cord structure;Macrophage;male;Measures;mechanical allodynia;Mechanics;Mediating;Mediation;Mediator;Messenger RNA;Microglia;migration;Modeling;Molecular;Morbidity - disease rate;mouse model;mRNA Stability;Mus;Natural Killer Cells;neglect;Nerve;nerve injury;Neuroglia;neuroinflammation;Neurons;neurotransmission;new therapeutic target;non-opioid analgesic;novel;novel therapeutics;Opiate Addiction;Pain;pain behavior;painful neuropathy;Pathway interactions;Patients;Penetration;Peripheral;Peripheral nerve injury;Persons;Phase;Pilot Projects;posttranscriptional;prevent;Process;Production;protein expression;Proteins;prototype;Publishing;Quality of life;Refractory;Regulation;Research Proposals;Resistance;response;RNA;Schedule;sex;Sex Differences;sexual dimorphism;Signal Transduction;small molecule;small molecule inhibitor;spared nerve;Spinal;Spinal Cord;stem;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;TNF gene;Translations;Trauma;Traumatic injury;Uridine;Veterans;Work

PROJECT_TITLE: RNA regulation of inflammatory mediators in glial cells: a novel therapeutic target for neuropathic pain after nerve injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURP-N (01)]


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: The VA patient population is characterized by a high prevalence of aortic stenosis. By developing new imaging tools to track disease progression and identifying new treatments, this project will help improve the management of patients with calcific aortic stenosis. Ultimately, this will improve the health of veterans and reduce healthcare costs.

PI_NAMEs: SADEGHI, MEHRAN M (contact)

PROJECT_TERMS: Address;Affect;Age;Aging;Animal Model;Animals;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Apolipoprotein E;beta catenin;Biological Process;Biology;BMP2 gene;calcification;Cell Culture Techniques;cell transformation;Cells;clinical translation;Data;Deposition;Development;Diagnostic;differentiation in vitro;Disease;disease heterogeneity;Disease Management;Disease Progression;disease-in-a-dish;Drug Screening;Evolution;Extracellular Matrix;Failure;Fibroblasts;Functional disorder;Gene Deletion;Gene Expression Profiling;Gene Modified;General Population;Genes;Goals;Health;Health Care Costs;hemodynamics;High Prevalence;Human;human disease;human model;hypercholesterolemia;Image;imaging approach;Imaging Device;Imaging Techniques;improved;In Vitro;in vitro Model;in vivo;in vivo imaging;inhibitor;innovation;interstitial cell;Intervention;Knowledge;Literature;MAP Kinase Gene;Medical;Minerals;MME gene;Modeling;Molecular;molecular imaging;Molecular Target;Morbidity - disease rate;mortality;mouse model;multimodality;Mus;Myofibroblast;new therapeutic target;Nodule;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteolytic;p38 Mitogen Activated Protein Kinase;Pathogenesis;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Play;Population;Prevalence;prevent;Property;Regulation;Research Personnel;Resolution;Risk Factors;Role;screening;Signal Transduction;Stenosis;structural imaging;success;Therapeutic Agents;therapeutic target;Tissues;tool;Tracer;treatment response;valve replacement;Veterans

PROJECT_TITLE: Molecular imaging and therapy in aortic valve calcification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CARB-R (01)]


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Exaggerated and irreversible scarring of body tissues, also known as fibrosis, occurs as a complication of various disease or, in some cases, for unknown reasons. Fibrosis can affect every organ or tissue and, when it develops, diminishes the quality of life and can be even deadly. Fibrosis is particularly prevalent in Veterans as a consequence of their military exposures. There is no cure for fibrosis and the available therapies provide limited to moderate relief. A body molecule called IL-33 works in conjunction with another molecule called ST2 to promote fibrosis. Previous studies focused on this IL-33 – ST2 axis and yielded important information that may allow for therapeutic targeting by innovative therapies. However, not all IL-33-driven features of fibrosis can be explained by this axis’ functioning. Our research has suggested that both IL-33 and ST2 can also contribute to the fibrotic process independently, in an “off-axis” fashion. We will study such independent contributions by IL-33 and ST2 to lay the ground for future development of better therapies against fibrosis.

PI_NAMEs: LUZINA, IRINA G. (contact)

PROJECT_TITLE: On- and Oﬀ-Axis Control of Fibrosis by IL-33 and ST2


PHR: Gut mucosal injury occurs commonly in patients with inflammatory bowel disease and critical surgical illnesses. Effective therapies to preserve the integrity of the intestinal epithelium and enhance recovery of damaged mucosa in patients with critical illnesses are limited. Achieving a better understanding of the pathogenesis of gut mucosal injury/erosions and developing effective therapies to protect the epithelium from injury and promote repair after wounding are still urgent challenges. Studies proposed in this renewal project are to determine the role and mechanism of two long noncoding RNAs, uc.230 and GAS5, in the regulation of intestinal mucosal injury and repair under critical pathological conditions. Completion of these experiments will create a fundamental basis for developing effective therapies to preserve intestinal epithelial integrity and enhance mucosal repair for our VA patients.

PI_NAMEs: WANG, JIAN-YING  (contact)

PROJECT_TERMS: Apoptosis;Autophagocytosis;Bacteria;Binding Proteins;Biological Process;Blood Circulation;Cell Communication;Cell Cycle;cell type;Cessation of life;Clinical;Code;Critical Illness;Defect;design;differential expression;Disease;effective therapy;Environment;Epithelial Cells;epithelial injury;Epithelium;experimental study;Funding;gastrointestinal epithelium;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goblet Cells;Growth;Gut Mucosa;H19 gene;heat injury;Homeostasis;Host Defense;Human;human disease;Ileitis;Impairment;Inflammatory Bowel Diseases;Injury;injury and repair;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Link;mammalian genome;Mediating;Membrane;Messenger RNA;migration;Minority;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mucous Membrane;Multiple Organ Failure;Mus;Natural regeneration;novel;novel therapeutics;operation;Operative Surgical Procedures;overexpression;Paneth Cells;Pathogenesis;Pathologic;Patients;Pattern;Poison;Post-Transcriptional Regulation;posttranscriptional;preservation;prohibitin;Proliferating;Proteins;Recovery;Regulation;repaired;response;RNA;RNA-Binding Proteins;Role;Sepsis;Stress;Testing;Time;Tissues;Transcript;Translations;Trauma;Ulcerative Colitis;Untranslated RNA;Veterans;Work;wound

PROJECT_TITLE: Posttranscriptional Control of Gut Mucosal Defense and Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE SWAN-Aging will fill important gaps in understanding the role of the menopausal transition, menopause related health changes and midlife aging on women’s health and functioning in early old age. Accordingly, it will provide useful information to guide clinical decisions in midlife and later life in women who have diverse life experiences and socioeconomic and racial/ethnic characteristics.

PI_NAMEs: BROOKS, MARIA MORI (contact);BURNETT-BOWIE, SHERRI-ANN M;DERBY, CAROL A.;HEDDERSON, MONIQUE MARIE;JANSSEN, IMKE ;KARLAMANGLA, ARUN S;KARVONEN-GUTIERREZ, CARRIE ANNE;MCCONNELL, DANIEL S;THURSTON, REBECCA C;WAETJEN, L ELAINE

PROJECT_TERMS: Adopted;Affect;Age;age related changes;Aging;American;Biological Assay;Black race;blood pressure elevation;Blood Vessels;Body Composition;Body System;Body Weight;bone;Bone Density;bone strength;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Characteristics;Chinese;Chronic;Clinic Visits;Clinical;clinical practice;Cognitive;cognitive disability;cognitive performance;cohort;Cohort Studies;Communities;Data;Data Collection;data management;Data Set;depressive symptoms;design;disability;disorder prevention;Early Intervention;enhancing factor;Enrollment;Ensure;ethnic difference;ethnic disparity;ethnic health disparity;Ethnic Origin;Event;falls;follow-up;Fracture;Future;Genitourinary system;Goals;Gonadal Steroid Hormones;Health;health determinants;Health Personnel;Hemorrhage;Hispanic;Hispanic Women;Hormonal Change;human old age (65+);indexing;Inflammation;Infrastructure;insight;Japanese;Knowledge;Laboratories;late life;Leadership;Life Expectancy;Life Experience;Life Style;Link;Lipids;Longitudinal cohort;Longitudinal cohort study;Measures;Medical;men;Menopause;Menstruation;Mental Depression;Mental Health;Methods;middle age;mortality;multi-racial;Musculoskeletal;Natural History;Osteoporosis;Outcome;Pattern;Perimenopause;Personal Satisfaction;physical conditioning;Physical Function;Physiological;Physiology;Population;Positioning Attribute;Postmenopause;Premenopause;preservation;Prevention program;prospective;psychosocial;psychosocial wellbeing;public health priorities;Quality of life;Race;racial difference;racial disparity;Research;Resources;Risk;Risk Factors;Role;Site;Sleep;socioeconomics;Structure;Study of Women's Health Across the Nation;Symptoms;System;Time;Translating;treatment program;Visit;White Women;Woman;Women's Health;Women's study

PROJECT_TITLE: The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Disability Research;Estrogen;Menopause;Neurodegenerative;Prevention;Women's Health Research

PI_NAMEs: BROOKS, MARIA MORI (contact)

PROJECT_TERMS: Activities of Daily Living;Affect;Age;Age Years;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Cardiac health;Cardiovascular Diseases;career development;Characteristics;Clinical;clinical practice;clinical research site;clinically relevant;cognitive function;Communication;Communities;Country;Creativeness;critical period;Data;data centers;Data Collection;Databases;Dementia;dementia risk;design;disability;Doctor of Philosophy;Education;Educational workshop;Enrollment;Ensure;epidemiologic data;Ethnic Origin;Event;follow-up;Fostering;Foundations;Future;Genitourinary system;graduate school;Health;Health Personnel;heart function;human old age (65+);Impaired cognition;Incidence;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Investigation;investigator training;Joints;K-Series Research Career Programs;Laboratories;late life;Lead;Leadership;Life;Life Experience;life span;Link;Longitudinal cohort study;Longitudinal Studies;Manuscripts;Measures;Menopause;Methods;middle age;mild cognitive impairment;modifiable risk;Monitor;multi-racial;multiple chronic conditions;Musculoskeletal;novel;Observational epidemiology;Observational Study;operation;organizational structure;Outcome;Participant;participant retention;participant safety;Perimenopause;physical conditioning;Physical Function;physical impairment;physically handicapped;Physiological;preservation;Prevention;Printing;Productivity;psychosocial;Public Health Schools;Publications;Quality of life;Race;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Resources;Risk Factors;Role;Science;Secure;Sex Functioning;Site;Sleep;socioeconomics;Strategic Planning;Structure;Study of Women's Health Across the Nation;success;System;Testing;Translating;Translations;United States;Universities;Vascular Dementia;Visit;welfare;Woman;Women's cohort;Women's Health;Women's study;Work;Writing

PROJECT_TITLE: Core 1: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Neurodegenerative;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: MCCONNELL, DANIEL S (contact)

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;American;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;bone health;Cardiac health;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Certification;Characteristics;Clinic Visits;Clinical;clinical research site;Cognition;Cognitive;Cognitive deficits;cognitive function;Collection;college;cost;critical period;cytokine;Data Analyses;data cleaning;Data Collection;data exchange;data management;Dementia;dementia risk;design;disability;Endocrine;Ensure;ethnic difference;ethnic health disparity;Ethnic Origin;Event;falls;Fracture;Freezing;Galectin 3;Genitourinary system;Glucose;Goals;Gonadal Steroid Hormones;Guidelines;Health;Health Personnel;healthy aging;Hormonal;Hormones;Hospitals;human old age (65+);Impaired cognition;improved;instrumental activity of daily living;Insulin;Interleukin-10;Laboratories;Laboratory Study;Language;late life;Leadership;Life Experience;life span;Ligands;Lipids;Liquid Chromatography;Literature;Mass Spectrum Analysis;Measurement;Measures;meetings;Menopause;Metabolic;metabolomics;Michigan;middle age;mild cognitive impairment;mortality;multiple chronic conditions;Musculoskeletal;Natural History;novel;Osteoporosis;Outcome;Ovarian hormone;Pathologist;Pathology;Pattern;Perimenopause;Physical Function;physical impairment;Positioning Attribute;Postmenopause;Preparation;preservation;prevent;psychosocial;psychosocial wellbeing;Quality of life;Race;racial difference;racial disparity;repository;Research Personnel;Resources;Risk;Role;Running;sample collection;Sampling;Science;Services;Sex Functioning;Shipping;Site;Sleep;socioeconomics;Specimen;Study of Women's Health Across the Nation;System;Testing;Translating;Universities;Vascular Dementia;Visuospatial;Woman;Women's Health;Women's study

PROJECT_TITLE: Core 2:  Laboratory Services Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Estrogen;Menopause;Neurodegenerative;Prevention;Women's Health Research

PROJECT_TERMS: actigraphy;Affect;age related changes;age-related disease;Aging;Alzheimer's Disease;Archives;bone;Cardiac;Cardiac health;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Characteristics;Clinical;Clinical Data;clinical research site;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cohort;Collaborations;Collection;critical period;Data;data centers;Data Collection;data de-identification;data management;Data Set;Dementia;dementia risk;design;disability;Doctor of Philosophy;Educational workshop;Enrollment;Ensure;epidemiologic data;Ethnic Origin;Event;experience;follow-up;Genitourinary system;Goals;graduate school;Health;Health behavior;Heart failure;Hormones;human old age (65+);Human Resources;Impaired cognition;improved;Incentives;Incidence;Infrastructure;instrumental activity of daily living;Laboratories;Language;late life;Lead;Leadership;Life Experience;life span;Link;Longitudinal cohort study;Longitudinal Studies;Manuscripts;Measures;Menopause;middle age;mild cognitive impairment;modifiable risk;Monitor;multi-racial;Musculoskeletal;Participant;participant retention;Perimenopause;Physical Function;physical impairment;Physiological;Play;pre-clinical;preservation;Process;Protocols documentation;psychosocial;Public Health Schools;Quality Control;Quality of life;Race;Reading;Research;Research Personnel;Resources;retention rate;Risk Factors;Role;sedentary lifestyle;Services;Sex Functioning;Sexual Health;Site;Sleep;socioeconomics;Specimen;Structure;Study of Women's Health Across the Nation;success;Technology;Testing;Training;Universities;Vagina;Vascular Dementia;vasomotor symptoms;Visit;Visuospatial;Well in self;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Core 3:  Data Collection & Data Management Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Dementia;Disability Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Mental Health;Neurodegenerative;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: HARLOW, SIOBAN D (contact)

PROJECT_TERMS: Address;Affect;Age;Age of Onset;age related;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;American;Black race;Bone Density;cardiovascular health;Characteristics;Chinese;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cohort;computerized data processing;Data;Data Analyses;Data Collection;Dementia;design;disability;Endocrine;Environment;ethnic difference;ethnic disparity;ethnic health disparity;Ethnic Origin;Ethnic Population;falls;family structure;Functional disorder;Future;Genitourinary system;Gonadal Steroid Hormones;Health;Health Personnel;health related quality of life;healthy aging;Hispanic;human old age (65+);Impaired cognition;Independent Living;inflammatory marker;insight;Japanese;Knowledge;late life;Life;Life Experience;Lipids;Maintenance;men;Menopause;Menstruation;middle age;mild cognitive impairment;Modeling;mortality;multiple chronic conditions;Musculoskeletal;Outcome;Pattern;Perimenopause;Personal Satisfaction;Physical Function;physically handicapped;Population;preservation;Prevention;prospective;Prospective Studies;psychosocial;psychosocial wellbeing;Quality of life;Race;racial difference;racial disparity;racial diversity;racial health disparity;reproductive senescence;Resources;Risk;Role;Sex Functioning;Sexual Health;Site;Sleep;Sleep disturbances;sleep health;social;socioeconomics;stressor;Study of Women's Health Across the Nation;Symptoms;therapy design;Translating;vasomotor symptoms;Well in self;White Women;Woman;Women's Health;Women's study

PROJECT_TITLE: Project 1: Influence of Midlife on Functioning and Psychological Well-being in Early Old Age


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Dementia;Disability Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Menopause;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: THURSTON, REBECCA C (contact)

PROJECT_TERMS: Acceleration;Affect;African American;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Attention;Blood Vessels;Brain natriuretic peptide;Cardiac;Cardiac health;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cause of Death;Characteristics;Chinese;Clinical;cognitive function;cohort;Cohort Studies;critical period;Dementia;dementia risk;Diabetes Mellitus;disability;disability risk;Disparity;Echocardiography;effective therapy;EFRAC;Equilibrium;Estradiol;ethnic difference;Ethnic Origin;Etiology;Event;experience;Female;Follicle Stimulating Hormone;follow-up;Functional disorder;Functional impairment;Goals;Gonadal Steroid Hormones;Health;Health Personnel;healthy aging;Heart failure;heart function;high risk;High Risk Woman;Hispanic Women;Hormones;Hospitalization;human old age (65+);Hypertension;Impaired cognition;improved;indexing;Inflammatory;Intervention;Japanese;Knowledge;late life;Life;Life Experience;life span;Link;Longitudinal cohort study;Measures;men;Menopause;middle age;Midlife women;mild cognitive impairment;mortality;multi-ethnic;multi-racial;Myocardial dysfunction;N-terminal;Natural History;new epidemic;Not Hispanic or Latino;Outcome;Participant;Pattern;Perimenopause;Phenotype;Physical Function;physical impairment;physically handicapped;Play;poor sleep;Population;pre-clinical;preservation;prevent;Prevention;prospective;Provider;psychosocial;Race;racial difference;Resources;Risk;Risk Factors;risk stratification;Role;Seminal;socioeconomics;Structure;Study of Women's Health Across the Nation;Symptoms;Testing;Thinking;Translating;Vascular Dementia;vasomotor symptoms;Woman;Women's Health;Women's mortality;Women's study;Work

PROJECT_TITLE: Project 2: Menopause, Midlife and Cardiovascular Health in Early Old Age


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Neurodegenerative;Osteoporosis;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: KARLAMANGLA, ARUN S (contact)

PROJECT_TERMS: Activities of Daily Living;adjudication;Age;Age Years;Aging;aging related;American;Blood Vessels;Body Composition;bone;Bone Density;bone loss;bone mass;bone strength;cardiometabolic risk;Cardiovascular system;Characteristics;Chronic;Clinical;Cognitive;cognitive function;cohort;design;Development;disability;Early Intervention;Educational Materials;Endocrine;Ensure;Environment;ethnic difference;ethnic disparity;ethnic diversity;ethnic health disparity;Ethnic Origin;Event;experience;falls;Fatty acid glycerol esters;Fracture;functional independence;Future;Genitourinary system;Goals;Gonadal Steroid Hormones;Health;Health Personnel;Hemorrhage;Hormones;human old age (65+);indexing;Inflammation;Intervention;Knowledge;late life;Life;Life Cycle Stages;Life Experience;Maintenance;Measurement;Measures;Menopausal Symptom;Menopause;Menstruation;Mental Health;Metabolism;middle age;Midlife women;mild cognitive impairment;multi-ethnic;muscle form;muscle strength;Musculoskeletal;older adult;older women;Osteoporosis;Outcome;Pattern;Perimenopause;physical conditioning;Physical Function;Physiology;Population;Positioning Attribute;preservation;Prevention;psychosocial;Public Health;Quality of life;Race;racial difference;racial disparity;Resources;Risk;Risk Factors;Role;sarcopenia;screening;Social Change;socioeconomics;Study of Women's Health Across the Nation;Symptoms;Testing;Thinness;Time;tool;Translating;Visit;Woman;Women's Health

PROJECT_TITLE: Project 3: Preservation of Musculoskeletal Health and Functioning in Early Old Age


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Disability Research;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: Mason

ORG_NAME: BIOINCEPT, LLC

PHR: PROJECT NARRATIVE Perinatal hypoxic-ischemic encephalopathy (HIE) can result in newborn death or long-term disability including cerebral palsy, epilepsy, increased hyperactivity, and developmental disorders, for which hypothermia treatment reduces mortality and developmental complications, although 40-50% of infants still die or suffer severe disabilities. The National Institute of Child Health and Human Development (NICHD) recently reported an urgent need to develop neuroprotective combination therapies to be used hours to days after the insult in combination with hypothermia. This project will test the efficacy of hypothermia plus a novel immunomodulatory compound, the synthetic Preimplantation Factor (sPIF), to develop a more effective combination treatment to prevent brain injury.

PI_NAMEs: BARNEA, EYTAN R (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acute;Adjuvant Therapy;Affect;Animals;Applications Grants;Area;Astrocytes;Autoimmune Hepatitis;Award;Behavioral;Blood flow;Brain;Brain Hypoxia-Ischemia;Brain Injuries;CASP3 gene;Cell Nucleus;Cells;Cerebral Palsy;Cessation of life;Clinical;Clinical Research;clinically relevant;cognitive function;Coma;Combined Modality Therapy;Cortical Blindness;delivery complications;dentate gyrus;Depressed mood;Development;developmental disease;disability;DLG4 gene;Dose;Drug Kinetics;effective therapy;efficacy testing;Epilepsy;Erythropoietin;experience;Frequencies;Functional Magnetic Resonance Imaging;Glial Fibrillary Acidic Protein;Glucose;gray matter;Heart;Hippocampus;Histology;Hour;Hyperactivity;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;immunoreactivity;immunoregulation;Impairment;improved;Infant;Injury;Intervention;Intestines;Ipsilateral;Kidney;Laboratory Finding;Ligation;Light;Live Birth;Liver;Long term disability;Long-Term Effects;meetings;Microglia;Modeling;mortality;Motor;motor disorder;mouse model;Muscle hypotonia;National Institute of Child Health and Human Development;natural hypothermia;Necrosis;Neonatal;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;Neonatal Mortality;neurobehavioral;neurobehavioral test;neurofilament;Neurologic;Neurological outcome;neuropathology;neuroprotection;nonhuman primate;novel;Nuclear;Organ;organ growth;Oxygen;pandemic disease;Patients;Perinatal anoxic ischemic brain injury;Perinatal Hypoxia;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Physical condensation;postsynaptic;pre-Investigational New Drug meeting;preimplantation;presynaptic;prevent;Progress Reports;prophylactic;Proteins;Psyche structure;Rattus;Reflex action;Reporting;Research Design;respiratory;response;Safety;Seizures;Sensorineural Hearing Loss;Serum;Shapes;Side;Small Business Innovation Research Grant;Small Business Technology Transfer Research;stem cells;subcutaneous;Survivors;Synaptophysin;System;Testing;Therapeutic;Time;Toxic effect;Toxicology;white matter;Writing;Xenon

PROJECT_TITLE: Synthetic PreImplantation Factor (sPIF) plus hypothermia to treat neonatal brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


PHR: NARRATIVE By lowering testosterone to castration level, androgen deprivation therapy shows efficacy in the treatment of prostate cancer. However, the treatment is associated with physiological and psychological side effects. This study investigates the effects of androgen deprivation on motivation and emotion processing. We will use extensive neurocognitive testing, questionnaire assessments, and multiple state-of-the-art techniques of brain imaging to characterize changes related to androgen deprivation and predict individual vulnerability to these risks. Knowledge gained from this study may help patients and clinicians with their decisions on treatment. Studying the cognitive and emotional side effects of cancer treatment may be of particular relevance to the veterans’ population where many have already suffered from service-related neurological and mental health problems.

PI_NAMEs: CHAO, HERTA HUEY-AN (contact)

PROJECT_TERMS: Affective;Aftercare;age acceleration;age effect;age related;age related changes;Aging;Alzheimer's disease related dementia;androgen deprivation therapy;Androgens;Anxiety;Beck depression inventory;Behavior;Behavioral;Benefits and Risks;Brain;Brain imaging;Cancer Patient;cancer therapy;Caring;Castration;Clinical;clinical decision-making;clinical predictors;Cognition;Cognitive;cognitive function;cohort;Compensation;Dementia;deprivation;Dimensions;Elderly;Emotional;emotional stimulus;Emotions;Etiology;Evaluation;Exhibits;Expenditure;experience;Face;Functional disorder;Goals;gray matter;healthy aging;Human;Hypothalamic structure;Impaired cognition;Impairment;improved;Individual;individual variation;Intervention;Knowledge;Laboratories;Lead;Life;Literature;longitudinal design;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medial;Mediating;Memory impairment;men;Mental Depression;Mental Health;Metastatic Prostate Cancer;military veteran;Motivation;Neoplasm Metastasis;neural;neurocognitive test;Neurologic;neuromechanism;Participant;pathological aging;Patients;Persons;physical conditioning;Physiological;Play;predictive modeling;Prefrontal Cortex;preservation;Process;Productivity;Prostate Cancer therapy;Psychological Side Effects;Quality of life;Questionnaires;Reaction Time;Regulation;Rehabilitation therapy;Research;research clinical testing;Research Personnel;response;Rest;Rewards;Risk;Role;Scheme;serial imaging;Services;Severities;side effect;Syndrome;Techniques;Testing;Testosterone;trait;Variant;Veterans;Vulnerable Populations

PROJECT_TITLE: Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: NARRATIVE Multidrug resistant Acinetobacter baumannii is a global health problem and significant issue within VA hospitals. Particularly, A. baumannii is a leading cause of hospital acquired infections as well as secondary infections in COVID-19 patients. Furthermore, A. baumannii has become increasingly difficult to treat due to antibiotic resistance, leaving few, if any, options for treatment; therefore, new approaches to treat these infections are critically needed. P-lactamase enzymes, which inactivate P-lactam antibiotics, are a nearly universal resistance mechanism present in A. baumannii; however, the collateral consequences due to P-lactamase overexpression are not well understood. I hypothesize that overexpression of the chromosomal AmpC P-lactamase in A. baumannii results in cellular changes that create new vulnerabilities, which will provide a better understanding of the problematic microbe and can be leveraged in novel antibiotic discovery.

PI_NAMEs: COLQUHOUN, JENNIFER MARIE (contact)

PROJECT_TERMS: Achievement;Acinetobacter baumannii;Advisory Committees;Antibiotic Resistance;Antibiotics;antimicrobial;Appointment;Automobile Driving;Bacteria;bacterial fitness;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Binding Proteins;carbapenem resistance;career;career development;Cell Physiology;Cell Shape;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Communities;Conserved Sequence;cost;COVID-19 patient;CRISPR interference;crosslink;Death Rate;design;Development;DNA Insertion Elements;emerging pathogen;Enterobacteriaceae;Enzymes;Escherichia coli;Essential Genes;Extramural Activities;Fortification;Foundations;Funding;Gene Expression;gene product;Genes;genetic approach;Genetic Predisposition to Disease;global health;Goals;Healthcare;Homeostasis;Hospitalization;Hospitals;host microbiome;Housekeeping;Human;Hypersensitivity;In Vitro;in vivo;Incidence;Infection;insight;Joints;Klebsiella pneumoniae;knock-down;Knowledge;Lactamase;Libraries;Link;Maintenance;medical schools;Mentors;Metabolic;Metabolism;Methods;Microbe;Modernization;Monobactams;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Multidrug-resistant Acinetobacter;Mus;mutant;Nosocomial Infections;novel;novel strategies;novel therapeutics;overexpression;pathogen;Pathogenesis;Patients;Peptidoglycan;Phenotype;Physiological;Physiology;Plasmids;pneumonia model;Prevalence;priority pathogen;professor;programs;promoter;Pseudomonas aeruginosa;Publications;Reporting;Research;Research Assistant;Research Personnel;Residual state;Resistance;resistance gene;resistance mechanism;Resources;response;Scientist;secondary infection;Septicemia;Serum;skill acquisition;skills;small molecule inhibitor;Testing;Therapeutic;therapeutic target;transcriptomics;transposon sequencing;United States;Universities;ventilator-associated pneumonia;World Health Organization

PROJECT_TITLE: Genetic Vulnerabilities Exposed by Intrinsic Beta-Lactamase Overexpression in Acinteobacter Baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

PHR: The broad objective of our research program is to understand the causal mechanisms responsible for stroke- induced sleep disturbances and to develop a translational approach to correct sleep deficits that will accelerate post-stroke recovery and rehabilitation.

PI_NAMEs: THAKKAR, MAHESH M (contact)

PROJECT_TERMS: Acceleration;Affect;age group;Animal Model;Animals;antagonist;Arteries;Attenuated;attenuation;axon growth;Behavior Therapy;Behavioral;Brain region;Caring;Cause of Death;Cell Death;Chronic;circadian;Circadian desynchrony;Circadian gene expression;Circadian Rhythms;Clinic;Clinical;Clinical Research;Cognitive deficits;Cognitive Therapy;combat;combat veteran;Corpus striatum structure;Coupled;debilitating symptom;Deglutition Disorders;design;designer receptors exclusively activated by designer drugs;Development;disability;DLG4 gene;Down-Regulation;Drowsiness;Economic Burden;Equilibrative Nucleoside Transporter 1;Excessive Daytime Sleepiness;experimental study;FDA approved;Gene Expression;Genes;Genetic;Goals;hemiparesis;Hemiplegia;Hippocampus;Homeostasis;Human;hypocretin;Impaired cognition;Impairment;improved;improved outcome;Incidence;Inflammation;innovation;interdisciplinary approach;Interruption;Intervention;Ischemia;Ischemic Stroke;Light;Measures;melanin-concentrating hormone;Memory impairment;middle age;middle cerebral artery;Middle Cerebral Artery Occlusion;Mission;Motor;mouse model;Mus;Neuroanatomy;Neurologic Dysfunctions;neurological rehabilitation;Neuronal Plasticity;Neurons;novel;novel therapeutics;Outcome;Patients;Peripheral;persistent symptom;pharmacologic;post stroke;pressure;Prevalence;prevent;Process;programs;Purinergic P1 Receptors;Quality of life;receptor;Recovery;Recovery of Function;Recurrence;rehabilitation strategy;Rehabilitation therapy;REM Sleep;Research;SIRT1 gene;Sleep;Sleep Deprivation;Sleep disturbances;sleep quantity;Sleep Wake Cycle;Sleeplessness;Stroke;stroke model;stroke patient;Stroke prevention;stroke recovery;stroke rehabilitation;stroke risk;stroke survivor;suprachiasmatic nucleus;Symptoms;Synaptic plasticity;Synaptophysin;targeted treatment;Techniques;Testing;Transgenic Organisms;translational approach;Vascular blood supply;Veterans;Wakefulness

PROJECT_TITLE: Sleep and Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURR-A (01)]


PHR: This project is to identify targets of metabolic dysregulation which promote pathogenesis in pulmonary hypertension (PH). PH has been reported to affect nearly 1 in 30 US veterans, and is currently an incurable disorder with significant decreases in quality of life and eventually leads to death. Dr. Smith's previous research involved identifying mechanisms of metabolic dysregulation by exposures to military personnel deployed in high-risk areas, and he seeks to apply his expertise of metabolism to PH. This project will identify critical targets associated with poorer prognosis by using platelets from individuals with PH as a biosensor. These results will be validated in a preclinical rat model of PH. Therefore, the proposed research will use advanced analytical and systems-biology related techniques to improve our understanding of the underlying mechanism of PH pathogenesis and to ultimately improve the care of veterans with the disease.

PI_NAMEs: SMITH, MATTHEW RYAN (contact)

PROJECT_TERMS: Address;advanced analytics;advanced system;Affect;Age;Animal Model;Animals;Area;Biochemical;Bioenergetics;Biogenesis;Bioinformatics;Biological Assay;Biosensor;Blood Platelets;Blood specimen;Blood Vessels;career development;Caring;Cells;Cessation of life;Characteristics;Clinical;clinical phenotype;comorbidity;Critical Pathways;Data;Development;Diagnosis;Disease;Environment;enzyme activity;Evaluation;Exposure to;Foundations;Funding;Genus Hippocampus;Heart;hemodynamics;high risk;Hypoxia;improved;improved outcome;Individual;Intervention;Isotopes;Lung;Measures;Membrane Potentials;Mentors;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Methods;Military Personnel;Mitochondria;mitochondrial dysfunction;Modeling;Morbidity - disease rate;mortality;Mus;novel strategies;novel therapeutics;Outcome;Oxidative Stress;Participant;Pathogenesis;Pathologic;Patients;Physiology;Plasma;pre-clinical;precision medicine;Predisposition;primary endpoint;Production;Prognosis;programs;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cell proliferation;pulmonary vascular cells;pulmonary vascular remodeling;Quality of life;Rattus;Reporting;Research;Retrospective cohort;Right Ventricular Hypertrophy;Sampling;Scientist;Serum;Severities;Smooth Muscle Myocytes;stable isotope;Subgroup;Systems Biology;Talents;Techniques;therapeutic target;Time;Tissues;Training;Translational Research;vascular bed;Vascular remodeling;Veterans

PROJECT_TITLE: Novel Approaches to Assess Metabolic Dysregulation in Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PULM-N (01)]