NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Immunotherapy;Microbiome;Nutrition;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: TEWARI, MUNEESH  (contact)

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Allogenic;Bacteria;bench to bedside;Benign;Bile Acids;Bioinformatics;Biological;Biometry;Butyrates;Cell Therapy;Clinic;Clinical;Clinical Trials;Collection;cost;Data;Death Rate;Development;Diet;dietary;Dietary Intervention;dietary manipulation;Dietary Supplementation;Digestive System Disorders;Disease;DNA analysis;Enzymes;Epithelial Cells;epithelial injury;Face;fecal transplantation;Feces;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;graft vs host disease;gut bacteria;gut microbes;gut microbiome;Hematological Disease;Hematology;Hematopoietic Stem Cell Transplantation;host microbiota;Human;Immunocompromised Host;Immunosuppression;improved;improved outcome;Incidence;Institution;Intervention;intestinal epithelium;Intestines;Joints;Laboratories;Life;Malignant - descriptor;Measurement;Mediating;member;Metabolism;metabolome;metabolomics;Metagenomics;Microbe;microbial;microbiome;microbiome alteration;microbiome composition;microbiome therapeutics;microbiota;mortality;mouse model;Mus;new technology;novel;Pathogenesis;Patient-Focused Outcomes;Phase II Clinical Trials;phase II trial;Pilot Projects;Plasma;Plasma Cells;Play;Potato;pre-clinical;prebiotics;Probiotics;prophylactic;Reporting;Research;Research Personnel;Resistance;RNA;Role;Safety;safety and feasibility;Severities;Severity of illness;Specimen;standard of care;Starch;stool sample;T-Lymphocyte;Technology;Testing;Tissues;Translating;Transplant Recipients;Volatile Fatty Acids;Work

PROJECT_TITLE: Clinical trial exploring the diet-microbiome axis in allo-HCT patients


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Contraception/Reproduction;Patient Safety;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRITESEED, LLC

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of this Commercialization Readiness Pilot (CRP) is to fund late stage technical assistance in the form of a complex manufacturing process and regulatory support for Briteseed’s laparoscopic vessel sealer with hyperspectral imaging based rapid ureter detection (HSI-RUD) capability. These activities will position the company to successfully partner with a major device manufacturer to co-develop a version of their vessel sealer with our HSI-RUD technology integrated into it or to bring to market a stand-alone Briteseed smart surgical device; which would be the first universal, unobtrusive and cost-effective ureter detection technology with the potential to decrease the incidence of ureteral complications during minimally invasive gynecological surgery (MIGS). Ureters are critical structures present in the same working space as many gynecologic organs of interest during MIGS procedures, and inadvertent injury to them occurs and leads major complications, costing hospitals an average of $30,000 per patient due to added hospitalization time and added procedures.

PI_NAMEs: SHUKAIR, SHETHA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Acute;Adoption;Algorithmic Software;Anuria;Architecture;Blood Vessels;Chronic;commercialization;commercialization readiness;Complex;Computer software;Consult;Consumption;Contrast Media;cost;cost effective;Custom;Cystoscopy;Deposition;design;Detection;detection method;detection platform;Development;Devices;Electronics;endometriosis;Ensure;Family suidae;Feedback;Fibroid Tumor;Financial Hardship;Fistula;Freezing;Funding;Goals;Grant;Gynecologic;Gynecologic Surgical Procedures;Health Care Costs;Healthcare Systems;Hospital Costs;Hospitalization;Hospitals;human data;Hysterectomy;Iatrogenesis;iatrogenic injury;Image;Incidence;Inflammatory;Injury;injury prevention;Institution;interest;Interruption;Investments;Kidney Failure;Learning;Length of Stay;manufacture;Manufacturer;manufacturing cost;manufacturing process;Marketing;meetings;member;minimally invasive;Non-Invasive Detection;novel;Operating Rooms;Operative Surgical Procedures;Optics;Organ;patient population;Patient-Focused Outcomes;Patients;Pelvis;Performance;Peritoneum;Phase;Pilot Projects;Positioning Attribute;Postoperative Period;pre-clinical;preclinical study;Preparation;prevent;Procedures;Process;product development;Protocols documentation;prototype;radical hysterectomy;Reflux;Regulatory Pathway;research and development;response;Risk;Safety;seal;sensor;signal processing;Small Business Innovation Research Grant;Software Engineering;Stents;Structure;Surgeon;Surgical Wound Infection;System;Tactile;Technology;Testing;Time;Tissues;tool;Translating;transmission process;Ureter;Ureteral obstruction;Urinary tract infection;Urologist;verification and validation;Vision;Visualization;Visualization software;Woman

PROJECT_TITLE: Custom Sensor Manufacturing and Regulatory Preparation Assistance for Novel Intraoperative Ureter Detection Device


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative Breast cancer is the most common cancer and the second leading cause of cancer deaths in women. Triple negative breast cancer disproportionately accounts for many of these deaths. The goal of this proposal is to investigate a novel treatment strategy through a Phase I and II clinical trial involving patients with high-risk triple negative breast cancer, in which treatment resistant triple negative breast tumor cells are forced into rapid cycling, and in the process, they become sensitive to conventional chemotherapy.

PI_NAMEs: TRAN, DAVID D (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute;Adjuvant;Adoption;Aftercare;Animal Model;Animals;arm;autocrine;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Cells;BRCA1 gene;BRCA2 gene;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;Breast Oncology;Bromodeoxyuridine;Cancer Etiology;cancer subtypes;capecitabine;Cell model;Cells;Cessation of life;Chemosensitization;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical Trials;computational platform;Critical Pathways;Cytokine Network Pathway;Cytotoxic agent;Data;Disease;Distant;Dose;driver mutation;Drug Combinations;efficacy testing;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;experience;Exposure to;Failure;FDA approved;Future;gene network;gene regulatory network;Genomics;Goals;Growth;high risk;Hormones;Human;IL-6 inhibitor;improved;In complete remission;Individual;inhibiting antibody;innovation;insight;Interleukin 6 Receptor;Interleukin-6;lymph nodes;Magnetism;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Mesenchymal;Metabolic Clearance Rate;Metastatic breast cancer;Methods;Microfluidic Microchips;Monoclonal Antibodies;mouse model;Nature;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;neutralizing monoclonal antibodies;novel;novel therapeutic intervention;Oral;Organ;p38 Mitogen Activated Protein Kinase;paracrine;Pathologic;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;phase 1 study;Phenotype;Positioning Attribute;pre-clinical;Primary Neoplasm;Process;Prodrugs;Progression-Free Survivals;Proliferating;receptor;Receptor Inhibition;Recommendation;Regimen;Reporting;Research Personnel;Residual Neoplasm;Resistance;Rheumatoid Arthritis;Risk;Role;Safety;Sampling;Signal Pathway;Signal Transduction;Site;Source;spatiotemporal;stem;Surrogate Markers;System;TACSTD1 gene;Techniques;Testing;Therapeutic;therapeutic target;therapy resistant;Toxic effect;transcriptome;Treatment Failure;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor microenvironment;Up-Regulation;Women's mortality

PROJECT_TITLE: Novel Methods of Chemo-sensitizing Low-proliferative Disseminated Tumor Cells in Triple Negative Breast Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: Project Narrative Bariatric surgery is a potent treatment for obesity-related metabolic disease and improves glucose control in T2D, but some individuals develop severe hypoglycemia (post-bariatric hypoglycemia, PBH), threatening safety. PBH is linked to increased insulin and incretin secretion, reduced secretion of glucagon and other counterregulatory hormones, and altered intestinal and whole-body metabolism, but current therapies remain incompletely effective. In this study, we will (a) analyze glucose and glucagon metabolism/sensitivity in the fasting, post-meal, and post-exercise states in patients with PBH, (b) use this information to develop a new closed-loop glucagon pump system responsive to the unique pathophysiology of PBH, and (c) test the system in a pilot randomized outpatient clinical trial.

PI_NAMEs: BASU, ANANDA ;PATTI, MARY E (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Algorithms;Automobile Driving;bariatric surgery;Bariatrics;base;Bicycling;Bile Acids;Biomedical Engineering;blood glucose regulation;Body Weight decreased;Bolus Infusion;Cellular Phone;Clinical;clinical care;clinical implementation;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Data;design;Development;Disease remission;Dose;Double-Blind Method;Drops;Engineering;Exercise;experience;Fasting;FGF19 gene;Functional disorder;Gastrectomy;Gastric Bypass;GCG gene;Glucagon;Gluconeogenesis;Glucose;glucose metabolism;glucose production;glucose sensor;glucose uptake;Glycogen;glycogen metabolism;glycogenolysis;Goals;Hormonal;Hormones;Hour;Human;Hyperglycemia;Hypoglycemia;hypoglycemia unawareness;Impairment;improved;in silico;Incidence;Individual;Infusion Pumps;innovation;Insulin;insulin secretion;Insurance;Intestines;Isotopes;Kinetics;Knowledge;Link;Liquid substance;Liver Glycogen;Measures;Metabolic;Metabolic Diseases;Metabolism;Modeling;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;obesity treatment;Outpatients;patient population;Patients;Physiology;Pilot Projects;pilot test;pilot trial;Placebo Control;placebo controlled study;Postprandial Period;Prevalence;prevent;Process;Pump;Randomized;rapid detection;Recurrence;research clinical testing;response;Risk;Safety;software development;success;System;Systems Development;Testing;Therapeutic;tool;VO2max;Water

PROJECT_TITLE: Glucagon Pump Therapy for Post-Bariatric Hypoglycemia:  Merging Physiology and Engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: CALLA HEALTH FOUNDATION

ORG_STATE: NC

PHR: Project Narrative The goal of this SBIR is for PIs from academic and small business institutions to work in partnership to develop a technological strategy that will transform treatment of cervical pre-cancer in low-income communities. The proposed research is significantly relevant to public health, as the developed technologies will contribute to the improvement of cervical cancer prevention, and thus a reduction in the mortality rate of this imminently preventable disease.

PI_NAMEs: CROUCH, BRIAN  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Ablation;Acute;Address;Adverse event;Affect;Alcohol consumption;Biological Assay;Businesses;Cellulose;Cervical;cervical cancer prevention;Cervix Uteri;Cessation of life;Clinic;Clinical;Clinical Research;Cold Therapy;combinatorial;Communities;Complex;conventional therapy;cost;Country;Data;Death Rate;Deposition;design;Diagnosis;Diameter;disability-adjusted life years;Disease;Electrocoagulation;Ensure;Ethanol;Excision;experimental study;Family suidae;Formulation;Foundations;Funding;Gel;Goals;Grant;Health;Hour;Human;improved;Income;Injectable;Injections;Institution;interest;intervention cost;Interview;Investigational New Drug Application;Length;Lesion;Link;Liquid substance;Liver neoplasms;loop electrosurgical excision procedure;low and middle-income countries;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;manufacture;medically underserved;Modeling;Monitor;mortality;Necrosis;Needles;Nitrogen;Outcome;Pelvis;Phase;point of care;Polymers;population health;potency testing;Power Sources;premalignant;pressure;prevent;Protocols documentation;prototype;Provider;Public Health;Quality Control;Radiofrequency Interstitial Ablation;Recurrence;Research;Research Design;safety assessment;screening;Small Business Innovation Research Grant;stability testing;Stains;Sterility;Surveys;Technology;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Translations;treatment arm;underserved area;usability;Vial device;Vision;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Optimizing ablation of cervical precancer with ethyl cellulose ethanol to enable translation to women in low and middle-income countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Data Science;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative: This cooperative project will create a federated computer system to bring many types of complex data of the human brain together with a virtual human brain tissue bank to advance translational research for both rare and common brain disorders. A multi-institutional platform, online training program, and virtual tissue and database of rare and valuable fresh human brain samples will be linked to highly curated data. This will fill an important void in translational research, advance clinical care and help develop new treatments for brain disorders.

PI_NAMEs: LOEB, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: 3-Dimensional;Adoption;Adult;Age;analytical tool;Award;Biological Markers;Blood Tests;Brain;Brain Diseases;Brain imaging;Brain Neoplasms;brain surgery;brain tissue;Chicago;Childhood;Cities;Clinical;clinical care;Clinical Research;clinical translation;cohort;Collaborations;Common Data Element;community engagement;Complex;complex data;Computer software;Computer Systems;computerized data processing;Data;Data Collection;data de-identification;Data Element;data harmonization;data integration;data modeling;data platform;Data Set;data sharing;data standards;data visualization;data warehouse;Databases;Diagnosis;Digital Imaging and Communications in Medicine;Disparate;E-learning;Education;Electrodes;Electroencephalography;electronic health data;Electronic Health Record;Electrophysiology (science);Epilepsy;Equipment and supply inventories;experience;federated data;Genetic;Genomics;Goals;Grant;Health;Histology;Histopathology;Home;Human;human data;human tissue;Illinois;Image;image visualization;imaging modality;improved;in vivo;Informatics;Information Systems;innovation;Institution;interoperability;Lesion;Link;Maps;Measures;metabolomics;Methods;Mind;Molecular;multimodal data;multimodality;National Center for Advancing Translational Sciences;Nature;neuropathology;Neuropsychology;novel therapeutics;Ontology;open source tool;Operative Surgical Procedures;patient engagement;patient population;Patients;Pediatric Hospitals;Phase;Physicians;Private Sector;Procedures;programs;Proteomics;Protocols documentation;Rare Diseases;Research;Research Personnel;Sampling;Secure;Seizures;Site;Standardization;success;surgery outcome;System;Techniques;Temporal Lobe Epilepsy;Testing;therapeutic target;three-dimensional modeling;Tissue Banks;tissue processing;Tissue Sample;Tissues;tool;Training;Training Activity;Training Programs;Translational Research;treatment planning;Universities;user-friendly;virtual;virtual human;Visualization;Work

PROJECT_TITLE: Integration and interoperability of complex data and tissues from the human brain


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: Project Narrative Osteoclasts are the sole bone resorbing cells. Dysregulation of osteoclasts results in excessive bone loss. At present, available strategies for prevention and the treatment of bone loss are accompanied by significant limitations, rendering prolonged use of them undesirable. By determining a cell-specific program causing bone loss, our study will provide a new way to prevent disease development.

PI_NAMEs: PARK-MIN, KYUNG-HYUN  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: ATAC-seq;Binding Sites;Biogenesis;Biological Assay;Biological Process;Bone Diseases;bone loss;Bone Resorption;cell type;Cells;ChIP-seq;CRISPR/Cas technology;Data;Development;Disease;Disease Progression;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;Functional disorder;gene editing technology;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide analysis;Health;Human;human disease;Hyperactivity;Individual;inducible gene expression;inhibitor;insight;Lytic;Metastatic Neoplasm to the Bone;Mus;Myelogenous;Names;novel;osteoclastogenesis;Osteoclasts;Osteoporosis;Pathogenesis;Pathologic;pathologic bone resorption;Patients;pharmacologic;Physiological;Play;Precision Run-On Sequencing;prevent;Prevention strategy;Process;programs;promoter;Proteins;Regulation;Regulator Genes;Rheumatoid Arthritis;RNA;RNA Polymerase II;Role;side effect;Small Interfering RNA;Synovial Cell;targeted treatment;Therapeutic;Therapeutic Intervention;TRANCE protein;transcription factor;Transcriptional Regulation;transcriptomics;Untranslated RNA

PROJECT_TITLE: Osteoclast programming and reprogramming during osteoclastogenesis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Neurosciences;Pain Research;Urologic Diseases;Women's Health Research

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

ORG_STATE: MI

PHR: NARRATIVE Chronic pelvic pain is a debilitating condition affecting up to 1 in 4 women worldwide that is very challenging to treat. This clinical study will evaluate sacral neuromodulation as a treatment strategy for chronic pelvic pain, and determine placebo effect, carry-over effect and treatment durability. In addition, we will assess cost- effectiveness of performing single stage sacral neuromodulation implant versus the standard of care two-stage approach.

PI_NAMEs: PADMANABHAN, PRIYA ;PETERS, KENNETH M (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Address;Adult women;Affect;Anxiety Disorders;Applications Grants;Area;Body System;care costs;care seeking;central sensitization;Chronic Care;chronic pelvic pain;Clinical Research;comorbidity;Complex;cost;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Device Removal;Devices;Dialysis procedure;Disease;effectiveness evaluation;Etiology;experience;falls;FDA approved;Fecal Incontinence;Female;Fostering;Frequencies;Functional disorder;Funding;Implant;implantation;improved;Incidence;innovation;International;Measures;men;Mental Depression;Mental Health;minimally invasive;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;neuroregulation;Non-Malignant;Organ;Outcome;Outcome Measure;Outcome Study;Pain;Pain management;pain patient;pain reduction;Participant;Pathology;Patient Care;Patients;Pelvic Pain;Pelvis;Persistent pain;Phase;Phenotype;placebo controlled trial;Placebo Effect;Placebos;Population;Procedures;prospective;psychologic;Quality of life;Questionnaires;Research;response;Retrospective Studies;secondary outcome;Sex Functioning;Sleep Disorders;standard of care;Standardization;Structure;Symptoms;Syndrome;Testing;Time;Treatment Efficacy;treatment strategy;urinary;Urinary Incontinence;Urinary Retention;urologic chronic pelvic pain syndrome;Urology;Woman

PROJECT_TITLE: Sacral neuromodulation for the management of chronic pelvic pain


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: Wakefield

ORG_NAME: SOCIETY FOR THE STUDY OF REPRODUCTION

PHR: PROJECT NARRATIVE The SSR annual meeting provides a venue, scientific program, and environment designed to stimulate learning and collaboration and engage attendees in critical scientific discussion with the goal of generating new knowledge leading to solutions in reproductive medicine, public health, agriculture, and conservation that will benefit humans and animals. A critical goal of our meeting is to enhance training and mentoring of a diverse cohort of trainees and support them as they progress through their careers.

PI_NAMEs: KRISHER, REBECCA L (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adolescent;Agriculture;Animals;Applications Grants;Award;Basic Science;Biology;career;Child;childcare allowance;Clinic;Clinical;cohort;Collaborations;Communication;Communities;Country;Development;Disabled Persons;Discipline;Environment;Environment Design;Environmental Risk Factor;Fertility;Fostering;Funding;Goals;Grant;Growth;Health;Human;Human Development;improved;innovation;interest;Knowledge;Lead;Learning;lectures;medical schools;meetings;member;Mentors;Mission;National Institute of Child Health and Human Development;next generation;Oral;Outcome;Parents;Participant;Physicians;Postdoctoral Fellow;posters;Program Reviews;programs;Public Health;Reproduction;reproductive;Reproductive Health;Reproductive Medicine;Research;Research Institute;Research Personnel;Science;Scientist;Site;Societies;success;teacher;Training;Translational Research;Travel;undergraduate student;Universities

PROJECT_TITLE: Annual Meeting of the Society for the Study of Reproduction

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal addresses critical computational challenges in the integrative analysis of spatial transcriptomics, histology images, and single cells. The successful completion of this project will allow researchers to take advantage of advanced machine learning algorithms to integrate multi-modal data to gain a holistic view of the spatial organization of tissues. The companion software packages will facilitate the translation of basic research findings into clinical studies of human disease.

PI_NAMEs: LI, MINGYAO  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Back;Bar Codes;Basic Science;Behavior;Benchmarking;Cell Communication;cell type;Cells;Cellular Morphology;Clinical;Clinical Research;Collaborations;Companions;Computer software;cost;Data;Data Analyses;Data Set;Detection;Disease;disease diagnosis;Environment;Eye diseases;Frontotemporal Dementia;Gene Expression;Gene Expression Profiling;Genes;Genomics;Hematoxylin and Eosin Staining Method;Histologic;Histology;human disease;Image;Joints;Kidney Diseases;Knowledge;Learning;Location;machine learning algorithm;machine learning method;Malignant neoplasm of lung;malignant stomach neoplasm;Maps;Measures;method development;Methodology;Methods;Modeling;Motivation;multimodal data;next generation sequencing;novel;open source;Pathology;Performance;Research Personnel;Resolution;self supervised learning;single-cell RNA sequencing;spatial integration;Spottings;Stains;Stroke;Structure;Technology;Tissue imaging;Tissues;training data;transcriptome;transcriptome sequencing;transcriptomics;Translations;ultra high resolution;virtual;Vision

PROJECT_TITLE: Integrative analysis of spatial transcriptomics with histology images and single cells

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Boston

ORG_DEPT: CHEMISTRY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Cyclic peptides are an exciting class of drug molecules capable of engaging challenging biological targets, and cyclic peptide natural products have been used in the clinic as immune system suppressants, antibiotics, and antifungals. Unfortunately, it is currently extremely challenging for researchers to design new cyclic peptide drugs to treat specific diseases because it is very difficult to predict the three-dimensional structures any cyclic peptide will adopt and to optimize their pharmacologic properties. In this proposal, we develop new computing algorithms that efficiently and accurately predict structures and properties of cyclic peptides, thereby allowing scientists to much more rapidly and robustly develop novel cyclic peptide drugs.

PI_NAMEs: LIN, YU-SHAN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Adopted;Affinity;Algorithms;Amino Acids;anti-fungal agents;Antibiotics;Area;Binding;Biological;Biological Availability;Biological Process;Cell Membrane Permeability;Cell Physiology;Characteristics;Clinic;Clinical Data;computational chemistry;computational platform;Computing Methodologies;Cyclic Peptides;Data;Descriptor;design;Development;Dimensions;Disease;drug development;Drug Modelings;extracellular;functional group;functional mimics;fundamental research;Goals;Immune system;improved;In Vitro;in vivo;inhibitor;innovation;invention;Location;Machine Learning;machine learning model;Marketing;Measures;Membrane Proteins;Methods;Modification;Molecular Conformation;molecular dynamics;Molecular Machines;Natural Products;novel;peptide drug;peptide natural products;Performance;Periodicity;Pharmaceutical Preparations;pharmacologic;Population;predictive modeling;preservation;Property;protein aminoacid sequence;protein protein interaction;Proteins;Protocols documentation;Reporting;Research;Research Personnel;Running;scaffold;Scientist;simulation;small molecule;Solubility;Solvents;Speed;Structure;Surface;therapeutic development;Therapeutic Intervention;three dimensional structure;Time;TIMP3 gene;tool;Training;training data;translational impact;user-friendly;Water;water solubility;Work

PROJECT_TITLE: Understanding and designing cyclic peptides

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Wound Healing and Care

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Macrophage-mediated inflammation is involved in the progression of many diseases, including arthritis, atherosclerosis, cancer, autoimmune diseases as well as chronic wounds. Metabolic reprogramming is a key hallmark of macrophage activation and function. The goal of this study is to gain more insight into the metabolic pathways that regulate macrophage function to better inform the development of new therapies for improved patient outcome.

PI_NAMEs: MISKOLCI, VERONIKA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Animals;Arthritis;Atherosclerosis;Autoimmune Diseases;Award;Biology;career;career development;Cell Physiology;Cell Respiration;Cells;chronic wound;Coenzymes;Communities;Complex;confocal imaging;Confocal Microscopy;Data;Defect;Development;Disease;Embryo;Ensure;Environment;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;Foundations;Functional disorder;Genes;Genetic;Goals;Growth;Human;human disease;Image;imaging approach;imaging modality;Immune;immunoregulation;improved;In Situ;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;insight;Institution;interstitial;K-Series Research Career Programs;Knowledge;Label;Larva;Leukocytes;Link;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Methodology;Mitochondria;Modeling;Monitor;mutant;Natural Immunity;non-invasive imaging;novel therapeutics;Optics;Patient-Focused Outcomes;Phase;Phenotype;Physiological;Play;Reactive Oxygen Species;recruit;Regulation;Reporter;Reporter Genes;Reporting;Research;Research Institute;Research Personnel;Resources;response;Role;skills;Sterility;Tail;Testing;Therapeutic;Time;Tissues;tool;Training;Transgenic Organisms;Work;wound;wound healing;Wound models;wound response;Zebrafish

PROJECT_TITLE: Metabolic regulation of macrophage-dependent wound healing in vivo

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  As the overdose crisis continues, some local prosecutors have increased their use of criminal legal penalties to address overdose deaths—despite evidence suggesting that doing so worsens public health outcomes for people who use drugs and their communities. Using a legal epidemiological framework, this study analyzes (1) the factors that influence prosecutors’ decisions to treat an overdose as a murder instead of a public health issue, (2) how such charges impact the health of people at risk of overdose, and (3) how investment in local public health efforts can decrease the involvement of the criminal justice system in addressing overdose deaths.

PI_NAMEs: EL-SABAWI, TALEED  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Administrator;Advanced Development;Affect;Area;Behavior;behavior influence;Black Populations;Charge;Collaborations;Communities;Community Health;Criminal Justice;Criminal Law;Data;Decision Making;design;Disparity;Drug usage;Drug user;economic disparity;Environment;Epidemiologic Methods;Epidemiology;Evaluation;evidence base;Exercise;experience;Health;health goals;Health Services Accessibility;Homicide;implementation science;implementation study;Imprisonment;improved;Infrastructure;insight;Intervention;Interview;Investments;Laws;Lawyers;Legal;Long-Term Effects;member;Mentored Research Scientist Development Award;Mentorship;Modeling;mortality;multidisciplinary;Murder;Nature;Needle-Exchange Programs;neighborhood disadvantage;North Carolina;novel therapeutics;opioid epidemic;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Play;Police;Policies;Populations at Risk;Prisons;Productivity;prototype;Public Health;public health intervention;Punishment;racial disparity;Recovery;Reporting;Research;Research Design;Research Personnel;response;Role;Rural;Safety;Severities;skills;Structure;substance use treatment;System;tool;Training;vulnerable community;Work

PROJECT_TITLE: The Influence of Public Health Infrastructure on Prosecutorial Responses to the Opioid Crisis

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Exposure to chronic stress is a risk factor for neuropsychiatric disease and yields both molecular and structural changes to the brain and immune system in clinical and preclinical models. As such, elucidating the neuroimmune substrates driving neuron subtype specific atrophy in brain reward regions and associated negative affective behaviors can inform novel therapeutics and enhance our ability to treat stress-related neuropsychiatric disorders, such as major depressive disorder. Here, I will use molecular and behavioral approaches to characterize the role of vitronectin, an extracellular matrix protein and promising molecular candidate hypothesized to drive stress-induced changes in the nucleus accumbens, to characterize its role in neuron-microglia interactions, morphology, and downstream behavioral outcomes to stress.

PI_NAMEs: FRANCO HERNANDEZ, DANIELA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Animals;Antigen-Antibody Complex;Anxiety;Area;Atrophic;Automobile Driving;Autopsy;Baltimore;Behavior;Behavioral;behavioral outcome;Brain;brain reward regions;career;Cd68;Cell Death;Cell Physiology;Cells;Cellular Structures;Central Nervous System;Chronic;Chronic stress;Clinical;Committee Members;Communication;Communities;Complement;CRISPR/Cas technology;cytokine;design;Development;differential expression;Dopamine Receptor;early life stress;Environmental Risk Factor;Exhibits;experience;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fellowship;Female;Foundations;Future;gene network;Generations;Glycoproteins;Goals;Image Analysis;Immune system;Immunologic Surveillance;immunoreactivity;Individual;Inflammation;interest;knock-down;Label;Learning;lens;Major Depressive Disorder;male;Maps;Maryland;Measures;Mediating;Mediator;medical schools;Membrane Proteins;Mental Health;Mentors;Microglia;Microscopy;migration;Molecular;Morphology;motivated behavior;Motivation;Mus;Myelogenous;Myeloid Cells;negative affect;Neuroimmune;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;Neurosciences;novel therapeutics;Nucleus Accumbens;Outcome;Patients;Peripheral;Phase;Play;post-doctoral training;post-traumatic stress;Postdoctoral Fellow;Pre-Clinical Model;pre-clinical research;preference;prevent;Process;Property;Proteomics;Research;Research Personnel;Research Project Grants;Rewards;Risk Factors;Rodent;Role;single-cell RNA sequencing;skills;social defeat;Social Interaction;social stress;Stress;stress reduction;stress related disorder;Sucrose;Synapses;System;Technology;Testing;Tissues;Training;transcriptome sequencing;Transgenic Organisms;Universities;Viral;Viral Vector;Vitronectin;Work

PROJECT_TITLE: The Role of Vitronectin in Neuron-Microglia Interactions in the Context of Social Stress

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: GLASSBORO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROWAN UNIVERSITY

PHR: PROJECT NARRATIVE Opioid drugs such as morphine are effective medications in treating pain but have profound side effects, including respiratory depression and addiction, thus there is a need to develop new analgesic treatment methods as an alternative to high dose opioids. We have discovered that combining morphine with MP-III-024, a drug that affects the GABA system, produces synergistic effects in models of pain relief, but not in models of opioid side effects, opening the possibility that dual MP-III-024/opioid treatments may allow for successful analgesia with reduced side effect risks. This proposal will systematically evaluate the therapeutic potential of a dual MP-III-024/opioid strategy and will aid in the development of new and improved treatments for pain- related disorders.

PI_NAMEs: KECK, THOMAS MCGOWAN (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute pain management;addiction;Affect;Affinity;Agonist;Amides;Analgesics;antagonist;antinociception;Base Ratios;behavior test;Behavioral;Binding;Biological Assay;Carbon;Charcoal;Chronic;chronic pain management;Clinical;Combination Drug Therapy;conditioned place preference;connective tissue-activating peptide;Constipation;Coupling;Dangerousness;Data;delta opioid receptor;design;Development;Disease;dorsal horn;Dose;Drug Combinations;efficacy evaluation;experimental study;Female;Fentanyl;Food;gamma-Aminobutyric Acid;improved;In Vitro;Investigation;kappa opioid receptors;Length;Ligands;male;Measures;Mediating;Mental Depression;Methods;Modeling;Morphine;Mus;Nociception;novel;novel drug class;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid use;Oxycodone;Pain;Pain management;pain model;pain relief;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Pharmacotherapy;Plethysmography;positive allosteric modulator;pre-clinical;prescription opioid;radioligand;receptor;Risk;Route;Safety;scaffold;side effect;Signal Transduction;spinal pathway;synergism;System;Testing;Therapeutic;transmission process;treatment strategy;Variant;Ventilatory Depression

PROJECT_TITLE: Combination drug therapy to treat pain with minimal or no abuse potential and side-effects

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Multiple social determinants of health (SDOH) underlie the staggering negative health outcomes among youth experiencing homelessness, including a lack of stable safe housing, income, education, food security, access to services, and intervention options, as well as high levels of discrimination, victimization and social isolation. Prevention efforts addressing these SDOH and that are embedded within systems that serve youth, such as drop-in centers, may be the most promising strategy to prevent opioid use and other substance use disorders as well as homelessness in adulthood. As such, this proposal addresses a significant public health concern, and if our hypotheses are supported, the intervention may be readily transported to communities around the country.

PI_NAMEs: FORD, JODI L. (contact);SLESNICK, NATASHA

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Address;Adolescence;Adult;adverse childhood events;Advocacy;Advocate;Affect;Age;aged;assault;Automobile Driving;Biological;biopsychosocial;biopsychosocial factor;Child Abuse;Child Abuse and Neglect;child neglect;Communities;comorbidity;comparison intervention;Complex;coping;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Country;design;Diagnosis;Discrimination;Disease;disorder prevention;Drops;Drug usage;Education;Effectiveness of Interventions;Emotional;Employment;Ethnic Origin;experience;Exposure to;Face;food security;Forcible intercourse;future implementation;gender minority status;Goals;Health;Health Services Accessibility;help-seeking behavior;Home;Homelessness;Hormones;Hospitals;Housing;human capital;Hydrocortisone;hypothalamic-pituitary-adrenal axis;implementation efforts;improved;Income;Individual;Inflammation;Inflammatory;innovation;Intervention;marginalization;Mediation;Mental Depression;Mental disorders;Mental Health;Motivation;motivational enhancement therapy;multiple drug use;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Outcome;outreach;Overdose;Pain;Pathway interactions;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;pragmatic intervention;prevent;Prevention;preventive intervention;Process;Psychological reinforcement;psychosocial resources;Public Health;Race;Randomized;Recording of previous events;Reporting;Research;resilience;response;Risk;Safety;Self Efficacy;service intervention;services as usual;sex;Sexual and Gender Minorities;skills;social;Social Environment;social health determinants;Social isolation;Social support;Social Work;societal costs;sociodemographics;Stress;Subgroup;substance misuse;substance use;Substance Use Disorder;substance use prevention;suicidal behavior;suicidal morbidity;System;Testing;Trauma;Victimization;Youth

PROJECT_TITLE: Building Social and Structural Connections for the Prevention of OUD among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE The main goals of this project are to define mechanisms that regulate PD-L1 internalization and intrinsic signaling to develop novel therapeutic approaches and overcome immunotherapy resistance in metastatic TNBC.

PI_NAMEs: OGRETMEN, BESIM  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;anti-PD-L1 therapy;anti-PD1 therapy;Apoptotic;Attenuated;beta catenin;Binding;Breast Cancer Cell;Breast Cancer Genetics;breast cancer metastasis;cancer cell;Cell membrane;cell motility;Cell surface;Ceramides;Clathrin;Clinical;Combined Modality Therapy;Complex;Data;design;dihydroceramide desaturase;Disseminated Malignant Neoplasm;Eligibility Determination;Endocytosis;Genetic;Goals;human tissue;Immunotherapy;improved;in vivo;Invaded;lipid metabolism;Lipids;Mediating;Mediator;Membrane;Metabolism;migration;Modeling;Molecular;mortality;mouse model;mRNA Stability;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;programmed cell death ligand 1;Publishing;Regulation;Reporting;Resistance;resistance mechanism;response;RNA-Binding Proteins;Role;SHH gene;Signal Transduction;smoothened signaling pathway;Sphingolipids;Surface;targeted treatment;TCF7L2 gene;Testing;Therapeutic;trafficking;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;tumor;tumor-immune system interactions

PROJECT_TITLE: Ceramide metabolism and the regulation of PD-L1 signaling to control metastasis and resistance to immunotherapy in TNBC


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Infectious Diseases;Lyme Disease;Neurosciences;Tickborne Diseases;Vector-Borne Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The proposed study aims to elucidate the neurobiology of neurocognitive symptoms associated with post- treatment Lyme disease (PTLD). Our goal is to generate fundamental knowledge about the activity and health of the brain, and to do so, this study will examine how white matter changes in structure and function throughout the course of Lyme disease. These findings may lead to the development of innovative prognostic and diagnostic tools as well as novel interventions to prevent or reduce the often significant cognitive symptom burden and functional impact of PTLD.

PI_NAMEs: MARVEL, CHERIE L (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Address;Affect;Aftercare;Antibiotic Therapy;Antibiotics;associated symptom;Axon;axon injury;Bacteria;Biological Markers;Blood;Borrelia;Borrelia burgdorferi;Brain;brain health;Case Series;CCL19 gene;Central Nervous System;chemokine;Clinical;clinical infrastructure;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Control Groups;cost;Data;debilitating symptom;Demyelinations;Development;Diagnosis;diagnostic tool;Diffusion Magnetic Resonance Imaging;Disease;Early treatment;erythema migrans;executive function;Exhibits;experience;Extravasation;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Goals;healing;Health;imaging modality;Impairment;Infection;Inflammation;Inflammatory;inflammatory marker;Injury;innovation;insight;Interleukin-6;Intervention;Iron;Knowledge;Ligands;Light;Longitudinal cohort;Longitudinal Studies;Lyme Disease;Magnetic Resonance Imaging;Measurement;Measures;Mediating;MRI Scans;multimodal neuroimaging;Myelin;Myelin Sheath;neural;Neurobehavioral Manifestations;Neurobiology;Neurocognitive;neurofilament;neuroimaging;Neurologic Symptoms;novel;novel diagnostics;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;patient stratification;Patient-Focused Outcomes;Patients;persistent symptom;Persons;Plasma;prevent;Process;prognostic;prognostic indicator;prognostic tool;Publishing;Radial;Recording of previous events;recruit;Reporting;Research;response;Risk;Structure;Symptom Burden;Symptoms;Testing;Therapeutic;tick transmission;Time;tool;Water;white matter;white matter change

PROJECT_TITLE: Neuroimaging and blood markers in post treatment Lyme disease with persistent neurologic symptoms


NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: RELEVANCE (See instructions): Gene expression is a tightly regulated and fundamental cellular process that is vital for organismal  physiology and is often altered in disease. These studies aim to understand molecular mechanisms that  govern gene expression through the chromatin landscape in response to changing environmental stimuli,  including alterations in the microbiota and cellular metabolism, and resulting impacts on cell biology.

PI_NAMEs: GATES, LEAH ASHLEY (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Acylation;Award;Binding;Biological Models;Biology;candidate identification;Carbon;Cell Physiology;Cell Separation;cell type;Cells;Cellular biology;Chemicals;Chromatin;commensal microbes;Complex;Coupled;Cues;Data;Diet;Diet Modification;dietary;Dietary Fiber;Disease;environmental change;Epithelial Cells;Equilibrium;experimental study;Fostering;Gene Expression;Gene Expression Regulation;Genes;Genetic Models;Genetic Transcription;Goals;Health;Histone Acetylation;histone modification;Histones;Homeostasis;Human;in vivo;Inflammation;insight;Instruction;intestinal epithelium;Intestines;Knock-out;Length;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mentors;Metabolic;Metabolic syndrome;Metabolism;metabolomics;Microbe;microbial;microbiota;Modification;Molecular;Mus;novel;Organism;Organoids;Phase;Phenotype;Physiological;Physiology;Play;post-doctoral training;Process;programs;protein complex;Proteins;Protocols documentation;Reader;Regulation;Reporting;Research Proposals;response;Role;Scientist;Side;Signal Transduction;skills;Stimulus;success;Testing;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome sequencing;Variant;Volatile Fatty Acids;Work

PROJECT_TITLE: Integration of metabolism and chromatin in regulating gene expression in vivo


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative People with HIV (PWH) experience increased rates of cardiovascular disease, despite often low traditional cardiovascular risk. The ongoing REPRIEVE trial is assessing whether statin therapy will effectively prevent major adverse cardiovascular events (MACE) and coronary atherosclerosis progression in a primary prevention cohort of PWH. This application seeks additional funds to extend REPRIEVE and allow for completion of the goals of the trial.

PI_NAMEs: DOUGLAS, PAMELA SUSAN;GRINSPOON, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adjudication;Angiography;Antibodies;Antibody Response;Arterial Fatty Streak;attenuation;Biological Factors;Black race;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;CCL2 gene;Characteristics;Clinical;clinical application;clinically actionable;Coagulation Process;cohort;Communities;Coronary;Coronary Arteriosclerosis;coronary computed tomography angiography;coronary plaque;Country;COVID-19;COVID-19 incidence;COVID-19 severity;Data;Data Coordinating Center;data management;Diet;Dyslipidemias;efficacy evaluation;Enrollment;Ensure;Environment;Epidemiology;Event;experience;Female;Fibrin fragment D;follow-up;Funding;Genes;Genetic;Glucose;Goals;Guidelines;Health;Heart failure;high risk;HIV;Immune;immune activation;immune function;Immunoglobulin A;Immunoglobulin G;Immunologics;improved;indexing;Infection;Inflammation;Inflammatory;Insulin;Integration Host Factors;Interleukin-6;Investments;Knowledge;Latino;Life Style;Link;Lipids;lipoprotein-associated phospholipase A(2);Liver Dysfunction;Long-Term Effects;Low-Density Lipoproteins;Malignant Neoplasms;Mediating;monocyte;Morphology;mortality;Myositis;National Heart, Lung, and Blood Institute;novel;Outcome;oxidized low density lipoprotein;Participant;participant enrollment;Pathway interactions;Persons;Phenotype;pleiotropism;Population;Populations at Risk;Positioning Attribute;predictive marker;prevent;Prevention strategy;Prevention trial;primary endpoint;Primary Prevention;Proteins;Proteomics;Protocols documentation;recruit;Risk;Risk Factors;Safety;SARS-CoV-2 infection;Serotyping;Severities;Site;Smoking;Symptoms;T-Lymphocyte;Time;transcriptomics;trial design;United States National Institutes of Health;Update;Viral Load result

PROJECT_TITLE: 1/2 REPRIEVE Extension for Trial Completion


NIH_SPENDING_CATS: Congenital Structural Anomalies;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Pediatric;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Congenital malformations of external genitalia are among the most common birth defects in humans, affecting ~1:150 live male births in the US. Correction can require multiple surgeries, and high complication rates are associated with tissue deficiencies and poor differentiation. This project will use single cell RNA sequencing to produce spatial and temporal atlases of the diversity of cell types in male and female mouse external genitalia. We will genetically decouple hormonally- and genetically-regulated sex differences. Nanoscale 3D imaging and single molecule visualization of RNAs will identify anchor genes for specific cell types and will map them back to embryonic tissues.

PI_NAMEs: COHN, MARTIN J (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Affect;ambiguous genitalia;Anatomy;Androgens;Animal Model;Appearance;Atlases;Back;Birth;Buffers;cell type;Cells;Clitoris;Complication;computerized tools;Congenital Abnormality;Data;Defect;Development;Disease;Embryo;embryo tissue;Endocrine Disruptors;Environmental Risk Factor;epidemiologic data;epigenomics;Estrogens;external genitalia;Failure;Female;fetal;Folic Acid;Four Core Genotypes;gene function;Genes;Genetic;Genetic Models;Genitalia;Genitourinary system;Goals;Gonadal Steroid Hormones;Growth;Hormonal;Hormones;Human;Hypospadias;imaging approach;imaging modality;improved;In Situ Hybridization;Incidence;innovation;innovative technologies;Knowledge;Link;Location;male;Male Genital Organs;Maps;Mediating;Metals;Methods;Molecular;mouse model;Mus;nanoscale;Neural Tube Defects;novel;Operative Surgical Procedures;Organ;penis;Prevalence;prevent;Prevention;Prevention strategy;reconstruction;Reporting;RNA;Role;sex;Sex Chromosomes;Sex Differences;Sex Differentiation;sexual dimorphism;Side;single cell ATAC-seq;single molecule;single-cell RNA sequencing;Specific qualifier value;Structure;surgery outcome;Three-Dimensional Imaging;Tissues;Transcriptional Regulation;transcriptomics;Transgenic Organisms;Treatment outcome;Tube;Urethra;Validation;virtual;Visualization;XX male;XY females

PROJECT_TITLE: Diversification of cell types during male and female external genital development


FUNDING_MECHANISM: OTHERS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: WU, CHUNLEI  (contact)

PROGRAM_OFFICER_NAME: BECK, TYLER

PROJECT_TITLE: Expanding the landscape of Translator Knowledge Providers using BioThings SDK and SmartAPI


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PI_NAMEs: GLUSMAN, GWÊNLYN  (contact);HADLOCK, JENNIFER

PROJECT_TERMS: Acceleration;Address;Big Data;Cell Line;Clinical;Collaborations;Collection;Communities;Complex;Data;Data Analyses;Data Analytics;data integration;Data Set;Disease;Electronic Health Record;Ethics;experience;FAIR principles;Gene Mutation;indexing;Individual;Ingestion;interest;interoperability;Knowledge;Knowledge Extraction;knowledge graph;knowledge integration;large datasets;Letters;Location;Machine Learning;Malignant Neoplasms;Manuals;Maps;Measurement;Methods;microbiome;novel;Ontology;Outcome;Pathway interactions;Pharmaceutical Preparations;Process;Proteins;Provider;Records;Research;Research Personnel;Resistance;Resources;Specific qualifier value;Standardization;success;synergism;Technology;Time;tool;Translational Research;tumor;Work

PROJECT_TITLE: DOCKET: accelerating knowledge extraction from biomedical data sets


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Hypertension;Kidney Disease;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This proposal will investigate the role of small non‐coding RNAs, termed microRNAs, in the regulation of sodium (Na+) transport in the distal kidney nephron. We will investigate the hypothesis that the mineralocorticoid hormone, aldosterone up-regulates the expression of specific miR clusters in the distal kidney nephron which feedback to negatively alter Na+ transport. We will test this novel function of microRNAs in Na+ homeostasis using control mice and a nephron-specific microRNA knockout mouse model that will be subjected to aldosterone stimulation and changes to renal Na+ handling will confirm that these microRNAs are acting as a negative feedback regulators of aldosterone signaling.

PI_NAMEs: BUTTERWORTH, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Address;Adrenal Glands;Aldosterone;Angiotensin I;Angiotensin II;Angiotensinogen;Angiotensins;arterial stiffness;Atrial Fibrillation;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;blood pressure regulation;Body Fluids;cardiovascular disorder risk;Cardiovascular system;Cell Line;Cells;collecting tubule structure;coronary fibrosis;Cortical Nephron;Cytoprotection;Data;desensitization;dietary;dietary salt;Disease;Distal;Duct (organ) structure;Electrolyte Balance;Epithelium;Equilibrium;Feedback;Female;Glucocorticoids;Heart Hypertrophy;Homeostasis;Hormones;Hour;Hyperaldosteronism;Hypertension;in vivo;Kidney;kidney cell;kidney fibrosis;Knockout Mice;Link;Messenger RNA;Metabolic syndrome;MicroRNAs;Mineralocorticoid Receptor;Mineralocorticoids;mortality;mouse model;Mus;Nature;Nephrons;novel;Nucleotides;osmotic minipump;Phosphotransferases;Physiological;Premenopause;Production;protein expression;Proteins;Regulation;Renin;Repression;Research Personnel;Resistant Hypertension;response;Risk;Role;salt intake;Serum;sex;Sex Differences;Signal Pathway;Signal Transduction;Signaling Protein;Sodium;steroid hormone;stroke risk;System;Testing;Time;tool;Untranslated RNA;Up-Regulation;Woman;women versus men

PROJECT_TITLE: Role of MicroRNAs in Kidney Sodium Regulation

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BOSTON

PHR: The proposed research is relevant to public health because it is focused on discovering new therapies for kidney diseases affecting how much water is in the body. Sometimes this process is not balanced, leading to diseases such as hypertension (too much fluid in the body) and dehydration (too much urine production). Our work is aimed at identifying basic mechanism in kidney cells that cause these diseases in order to develop drugs to cure them.

PI_NAMEs: BROWN, DENNIS  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Actin-Binding Protein;Actins;Address;Affect;Animals;antidiuretic;aquaporin-2;arm;Biological Assay;Biological Products;Cell membrane;Cell Physiology;Cell surface;Cells;Cellular biology;Clinical;Clinical Treatment;Clinical Trials;cohort;Complex;Congestive Heart Failure;Cytoskeleton;Data;Defect;Dehydration;depolymerization;design;Development;Disease;Down-Regulation;Duct (organ) structure;EGF gene;Electrolytes;Endocytosis;enzyme activity;Epidermal Growth Factor Receptor;Epithelial Cells;equilibration disorder;Equilibrium;Erlotinib;Event;Exocytosis;ezrin;F-Actin;Failure;Follow-Up Studies;Funding;genetic regulatory protein;Goals;Growth Factor Receptors;Health;Homeostasis;Hypertension;Hyponatremia;Inherited;inhibitor;Ion Channel;Kidney;kidney cell;Kidney Diseases;Knowledge;Ligands;Link;Liquid substance;live cell imaging;Membrane;Modification;Molecular;novel;novel therapeutic intervention;novel therapeutics;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiology;Play;Process;Production;protein transport;Proteins;Public Health;receptor;Receptor Activation;Receptor Cross-Talk;Receptor Signaling;Recycling;Regulation;Regulatory Pathway;Renal function;Research;Retrieval;Ribosomal Protein S6 Kinase;Role;RPS6KA gene;Signal Pathway;Signal Transduction;Specificity;superresolution microscopy;Techniques;therapeutic target;trafficking;Translating;Urine;Vasopressin Receptor;vasopressin resistant diabetes insipidus;Vasopressins;Water;water channel;water treatment;Work

PROJECT_TITLE: Cell Biology of Vasopressin-induced Water Channels

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Kidney Disease;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Lysosomal storage diseases are caused by genetic defects leading to anomalous accumulation of metabolites in lysosomes, the degradative and recycling compartment of the cell. These toxic products, when accumulated in large amounts, can be harmful to humans. The identification of novel mechanisms that regulate autophagy and compounds that improve cellular and organ function would lead to novel treatments for several human diseases including lysosomal storage disorders.

PI_NAMEs: CATZ, SERGIO DANIEL (contact);CHERQUI, STEPHANIE ;CUERVO, ANA MARIA;GAVATHIOTIS, EVRIPIDIS

PROJECT_TERMS: Affect;Animal Model;Apoptosis;Autophagocytosis;Biochemical;Brain;Cell Compartmentation;Cell Death;cell dedifferentiation;Cell model;Cell Physiology;Cells;Cellular biology;Cessation of life;Child;Chronic Kidney Failure;Clinical;Complement;Complementary therapies;Cysteamine;Cystine;Cystinosis;Data;Defect;detection of nutrient;Deterioration;Development;Disease;Down-Regulation;Event;Eye;Failure;Fanconi Syndrome;Functional disorder;functional improvement;Goals;Growth;Homeostasis;Human;human disease;Human Pathology;Impairment;improved;in vivo;Injury to Kidney;Kidney;LDL-Receptor Related Protein 2;Lead;Link;Liver;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Molecular;Molecular Chaperones;Mus;mutant;Mutation;nephropathic cystinosis;Nervous System Disorder;novel;novel therapeutics;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;pediatrician;Pharmaceutical Chemistry;Predisposition;Proteins;receptor;reconstitution;Recycling;Regulation;Renal function;repaired;Research;Role;small molecule;superresolution microscopy;Testing;tissue injury;Tissues;trafficking;translational approach;young adult

PROJECT_TITLE: Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The kidney is a complex organ whose essential roles include filtering waste from the blood, regulating blood pressure, and maintaining electrolyte balance. This project will develop a microscopy-based technique to study the organization of the genome of kidney cells and it will use the new technique to study aging in model mouse kidney tissue. The tools and findings of this project will enable researchers to study genome organization in kidney or other tissues and will illuminate the molecular details of aging.

PI_NAMEs: VAUGHAN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Adult;Aging;aging related;American;base;Blood;blood pressure regulation;Cells;Cessation of life;Chromatin;Chronic Kidney Failure;Complex;Correlative Study;Cultured Cells;design;Dialysis procedure;Disease;Dissociation;DNA;DNA Methylation;Electrolyte Balance;End stage renal failure;Endothelial Cells;Epigenetic Process;epigenetic profiling;Evaluation;Face;field study;Fluorescent in Situ Hybridization;Generations;Genome;genome-wide;genomic locus;glomerular basement membrane;Goals;Health Expenditures;healthy aging;Heterochromatin;histone modification;Histones;human old age (65+);Image;In Situ;Individual;Injury;innovation;insight;Kidney;kidney cell;Kidney Diseases;kidney imaging;Maps;Measures;Methods;microscopic imaging;Microscopy;Molecular;Molecular Conformation;molecular phenotype;mouse model;Mus;nanoscale;novel;Organ;Phenotype;Physiological;Physiology;podocyte;Population;Post-Translational Protein Processing;Publishing;Renal function;Research Personnel;Risk;Role;senescence;single cell analysis;Specimen;Stains;superresolution microscopy;Techniques;Technology;Time;Tissues;tool;Transplantation;ultra high resolution;Use of New Techniques;wasting;whole genome;Work

PROJECT_TITLE: in situ Epigenetic Profiling of Single Cells in Kidney

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE: NOVEL ROLE OF NEPHRON EPITHELIALIZATION IN NUCLEAR SIGNALING Formation of tubules is essential for the development of the kidney and urinary tract, and failure of this process results in urogenital anomalies, which occur in almost 2% of the world population and represent nearly one- fourth of all birth defects. Kidney tubule malformations result from disruption of either of two groups of proteins, the planar cell polarity (PCP) or exocyst proteins, but how they affect the formation of tubules in the developing kidney is not well understood. This study is significant because it will uncover how these protein groups work together to form the kidney tubules, improving our understanding of the mechanisms underlying prevalent birth defects involving the kidney.

PI_NAMEs: MILLER, RACHEL KATHERINE (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Actins;Address;Adherens Junction;Adhesions;Affect;Area;Attenuated;Automobile Driving;beta catenin;Biological;Birth;Body System;Cadherins;cell assembly;Cell Communication;Cell Nucleus;Cells;Childhood;Complex;Congenital Abnormality;congenital anomalies of the kidney;Data;Defect;Development;Developmental Process;Embryo;End stage renal failure;Epithelium;experimental study;Failure;Funding;Generations;Genetic;Genitourinary system;Goals;Grant;Human;Image;improved;in vivo;insight;Intercellular Junctions;Kidney;Kidney Transplantation;malformation;Mediating;Microfilaments;Modeling;Morphogenesis;nephrogenesis;nephron progenitor;Nephrons;novel;Nuclear;Pathologic;Pathway interactions;planar cell polarity;polymerization;Polymers;Population;Process;Proteins;Quantitative Evaluations;Regulation;Renal function;Renal tubule structure;Research;Role;Signal Transduction;stem cells;Testing;Urinary tract;Vesicle;WNT Signaling Pathway;Work;working group;Xenopus

PROJECT_TITLE: Novel Role of Nephron Epithelialization in Nuclear Signaling

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Kidney Disease

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICIs) are immunotherapies increasingly used in patients with wide varieties of cancers; however, they can also cause autoimmune toxicities affecting multiple organ systems, including the kidney. Currently, the pathogenesis of ICI-induced kidney injury is not well-understood, and epidemiologic studies suggest a high fraction of ICI-treated patients develop clinically-significant decline in kidney function over time. Using single-cell genomics and longitudinal biomarker studies, this proposal seeks to identify pathways that can help understand how acute and chronic kidney disease develops after ICIs to ultimately lead to novel diagnostic and therapeutic strategies to prevent kidney disease.

PI_NAMEs: SISE, MEGHAN E. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Adaptive Immune System;Address;adjudication;Affect;Albuminuria;Antitumor Response;autoimmune toxicity;Automobile Driving;Benchmarking;biobank;Biological;Biological Markers;biomarker identification;Biopsy;Blood;Body System;cancer care;cancer cell;Cancer Center;Cancer Patient;cancer therapy;cancer type;Caring;Cell Physiology;cell type;Cells;checkpoint therapy;Chronic;Chronic Kidney Failure;Clinical;clinically significant;cohort;comparison control;cytokine;Cytotoxic T-Lymphocytes;Development;Diagnosis;Disinhibition;Eligibility Determination;Enrollment;epidemiology study;Excision;Exhibits;experience;Future;Gene Expression Profiling;General Hospitals;Genetic Transcription;Glomerular Filtration Rate;Goals;Healthcare Systems;hemodynamics;high risk population;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunotherapy;Inflammatory;Infrastructure;inhibiting antibody;Injury;Injury to Kidney;innovation;insight;Interleukin-6;Interstitial Nephritis;Intervention Studies;Kidney;kidney biopsy;Kidney Diseases;Lymphocytic Infiltrate;Malignant Neoplasms;Massachusetts;Measures;Mediating;Melanoma;member;Molecular;Monoclonal Antibodies;multidisciplinary;noninvasive diagnosis;novel diagnostics;novel therapeutic intervention;Oncologist;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;Positioning Attribute;prevent;Principal Investigator;programs;prospective;protein biomarkers;Publishing;recruit;Renal function;Research Design;Research Personnel;Research Project Grants;Role;Services;side effect;single cell genomics;single-cell RNA sequencing;Specimen;Survivors;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technology;therapy design;Time;Tissues;TNF gene;Toxic effect;translational research program;Urine;Work

PROJECT_TITLE: Mechanisms driving acute and chronic kidney function decline after immune checkpoint inhibitor therapy for cancer

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: DUMONTIER, MICHEL ;TA, CASEY NGHIA;WENG, CHUNHUA  (contact)

PROJECT_TERMS: Knowledge

PROJECT_TITLE: Translator Red Knowledge (TReK)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Racial disparities in the incidence and treatment of end-stage kidney disease are well-documented and largely consistent across outcomes, and an emerging consensus indicates that these disparities are likely to be primarily driven by structural racism (SR). We will develop theoretically-driven, innovative measures of SR using restricted microdata and other sources, analyze the role of SR in racial/ethnic disparities in end-stage kidney disease incidence and mortality outcomes, determine how best to operationalize meaningful racial/ethnic disparities in sequences of kidney disease therapies, and work with two established community advisory boards to develop proposed interventions to ameliorate racial/ethnic disparities in kidney disease on the basis of our findings.

PI_NAMEs: DAW, JONATHAN KYLE (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Affect;Alaska Native;Alaska Native population;American Indians;Black race;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinical;Communication;Communities;community advisory board;community engagement;complex data;Consensus;Data;Data Analyses;Data Set;Demographer;Development;Dialysis procedure;Dimensions;Disease;disease disparity;Disparate;Disparity;Economics;Education;Eligibility Determination;End stage renal failure;ethnic disparity;ethnic minority;Ethnic Origin;Etiology;experience;Future;graft failure;hazard;Health;Health Professional;Health Services;Health Surveys;Healthcare;Hemodialysis;high risk;Hispanic;Hispanic Populations;Incidence;Information Systems;innovation;Institution;Institutional Policy;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Life Cycle Stages;Link;living kidney donor;Measures;Medical;Medicare;Medicare claim;mortality;Not Hispanic or Latino;novel;optimal treatments;Outcome;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Peritoneal Dialysis;Politics;Population;Positioning Attribute;post-transplant;Process;Race;racial disparity;racial minority;Research;Research Personnel;Respondent;Role;Sampling;Selection Bias;Sequence Analysis;shape analysis;Social Conditions;Social Policies;Source;Structural Racism;Surveys;Survival Rate;Techniques;Testing;Time;Transplantation;treatment disparity;United States;Waiting Lists;Work

PROJECT_TITLE: The Impact of Structural Racism on Racial/Ethnic Disparities in End-Stage Kidney Disease from Healthy Population to Mortality


ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE  We anticipate that retinoic acid receptor (RAR) β agonists will be useful in diminishing the severity of nephropathy in several murine models of chronic kidney disease. Data from this study could lead to new molecular targets for the treatment of various kidney disorders.

PI_NAMEs: GUDAS, LORRAINE J (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acute;Adult;Advanced Development;Affect;Agonist;Agriculture;All-Trans-Retinol;American;Area;Binding;Biochemical;Bioinformatics;Biology;Body System;Cardiovascular system;cell type;Cells;Chronic Kidney Failure;Data;Development;Diabetes Mellitus;Diet;Disease;disease model;Drops;efficacy testing;experience;Food Interactions;Funding;Gene Targeting;Genes;Genetic;genetic approach;Genetic Transcription;global health;Glomerulonephritis;Grant;Health;Human;Hypertension;Injury;Injury to Kidney;Kidney;kidney cell;Kidney Diseases;kidney fibrosis;Laboratories;Lead;Life;Manuscripts;Measurement;medical schools;Medicine;Methods;Micronutrients;Modeling;Molecular;molecular targeted therapies;Mothers;mouse model;Mus;nephrogenesis;Nephrolithiasis;Nephrons;New York City;novel;novel therapeutic intervention;novel therapeutics;nutrition;Obesity;Pathologic;Pathologist;Pathology;pharmacologic;Pharmacology;Play;Polycystic Kidney Diseases;Population;Positioning Attribute;Postdoctoral Fellow;Pregnancy;Prevalence;pup;RARB gene;Receptor Signaling;Renal Carcinoma;Renal function;Research;Research Personnel;Retinoic Acid Receptor;retinoic acid receptor alpha;retinoic acid receptor gamma;Retinoids;Role;Severities;Signal Transduction;Specialist;success;Syndrome;Testing;Therapeutic;tool;toxicant;Tretinoin;Vitamin A;Vitamin A Deficiency;Vitamins

PROJECT_TITLE: Gene Nutrient Interactions in Kidney Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There are currently over 110,000 patients on the organ transplant waiting list in the US, a number that far exceeds the supply of available organs. A major reason is the limitations of our current organ preservation technology, which disallows the transplantation of marginally injured organs and limits preservation duration. This project aims to improve public health by developing a protocol to bank organs for several weeks up to a few months, enabling global organ matching and potentially utilization of organs unusable with current technology.

PI_NAMEs: TONER, MEHMET  (contact);UYGUN, KORKUT ;YARMUSH, MARTIN L

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Animals;animation;Antioxidants;Bacteria;Bioenergetics;Blood Vessels;cell injury;Cell Survival;Cells;Cellular Morphology;Charge;Chimerism;Circulation;Citric Acid Cycle;cold temperature;cost;Crystallization;Data;Endothelial Cells;Endothelium;Engineering;Exhibits;experience;extracellular;Extracellular Space;Fatty Acids;Freezing;Funding;Glutathione;Hour;Human;Ice;improved;inhibitor;Injury;innovation;ischemic injury;Legal patent;Length;Liver;liver preservation;liver transplantation;Location;Measures;Metabolic;metabolomics;Methods;Microscopic;Modeling;Molecular;Movement;natural hypothermia;Nature;Operative Surgical Procedures;Organ;Organ Donor;organ injury;Organ Preservation;Organ Transplantation;oxidation;Oxygen;Patients;Perfusion;Permeability;point of injury;preconditioning;preservation;prevent;programs;Protocols documentation;Public Health;public health relevance;Rana;Rattus;Recovery;Reperfusion Injury;Research;Rodent;scale up;shear stress;Signal Transduction;success;System;Technology;Temperature;Time;Tissue Engineering;Tissues;Toxic effect;transcriptome sequencing;Transplantation;Trehalose;Vascular Endothelium;vascular injury;Vascular resistance;Viscosity;Waiting Lists;wasting;Wood material

PROJECT_TITLE: High subzero preservation of liver for transplantation

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Microbiome;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: WRIGHT, ANNE L. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Arizona;Asthma;asthma model;Birth;Blood;Blood specimen;Child;Childhood;Childhood Asthma;Chronic Disease;Clinic;Clinical;Cohort Studies;Collaborations;Collection;Communities;Data;Data Collection;data resource;Databases;Development;Diet;Disease;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Equipment and supply inventories;experience;Exposure to;Farming Community;Feces;fetal;follow-up;Genes;Goals;gut microbes;gut microbiome;gut microbiota;Health;High Prevalence;Home;Home environment;human microbiota;Human Resources;Immune;Immune response;Immunologics;Infant;Infrastructure;Laboratories;Life;Low Prevalence;Mexican;Mexican Americans;Mexico;Microbe;microbial;microbial community;microbiome;microbiome research;microbiota;Mothers;mouse model;Natural experiment;Outcome;Pattern;pet animal;Population;Pregnancy Trimesters;Pregnant Women;prenatal;prenatal exposure;Prevalence;programs;Quality Control;Questionnaires;recruit;Research;Resources;Risk;sample collection;Sampling;Smoking;Specimen;stool sample;Study Subject;Swab;Third Pregnancy Trimester;Vagina;Woman

PROJECT_TITLE: Recruitment, Data Collection & Sample Management Core


PI_NAMEs: MARTINEZ, FERNANDO D (contact)

PROJECT_TERMS: Agreement;Animals;Arizona;Asthma;Birth;Businesses;California;Child;Childhood Asthma;cohort;Communication;Communities;Complex;conflict resolution;Data Analyses;data management;design;Development;Ensure;Environmental Risk Factor;experience;Fostering;Funding;Genes;Goals;Grant;Human Resources;Human Subject Research;Immune;Information Dissemination;Infrastructure;Institution;Lead;Life;meetings;member;Mexican Americans;Mexico;Microbe;microbial;microbial community;microbiome research;Monitor;Outcome;Participant;prenatal;programs;Publications;Regulation;Research;Research Personnel;Research Training;Resources;response;Risk;Role;San Francisco;Schedule;Specimen;Structure;symposium;synergism;timeline;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MCCAULEY, KATHRYN  (contact)

PROJECT_TERMS: Arizona;Asthma;Biological Assay;Biological Markers;Biometry;California;Child;Child Development;Childhood;Collaborations;Complementary DNA;cost;critical period;Data;data integration;Data Set;Development;Disparity;DNA;Electrical Resistance;Environment;Epithelium;Equipment;experience;Extrinsic asthma;Generations;Genomic DNA;genomic RNA;Goals;gut microbes;gut microbiome;gut microbiota;Human Resources;Hypersensitivity;Immune;immunoregulation;Infant;Infrastructure;Laboratories;Libraries;Life;Link;Lipids;Longitudinal Studies;Medicine;metagenomic sequencing;Metagenomics;Methodology;Mexican;Mexican Americans;Mexico;microbial;microbial host;microbiome;microbiome research;microbiota;microbiota profiles;Microfluidics;Mothers;nasal microbiota;Neonatal;Nucleic Acids;Outcome;outcome disparities;plasmid DNA;Plasmids;Pregnancy;prenatal;Preparation;Process;Production;Protocols documentation;Ribosomal RNA;RNA;Robotics;Sampling;Sampling Studies;San Francisco;Schools;screening;Secure;sequencing platform;Shotguns;Standardization;stool sample;Time;Universities;Variant;Work

PROJECT_TITLE: Microbiome Studies


NIH_SPENDING_CATS: Asthma;Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Lung;Microbiome;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: BILLHEIMER, DEAN  (contact)

PROJECT_TERMS: Address;Arizona;Asthma;Bioinformatics;Biological;Biometry;Birth;Child;Childhood Asthma;Code;cohort;Cohort Studies;comparison group;Custom;Cytometry;Data;Data Analyses;Data Collection;data integration;data management;data modalities;Data Science Core;Data Scientist;Data Set;design;Development;Ensure;Environment;Environmental Exposure;epidemiology study;Epigenetic Process;experience;Experimental Models;experimental study;Exposure to;Fostering;gene product;Genetic;Goals;high dimensionality;Immune system;Inflammation;Informatics;Knowledge Management;Life;Locales;Manuscripts;metabolomics;Methods;Mexican Americans;Mexico;microbial;microbial colonization;microbiome;microbiome research;microbiota;Modality;Modernization;mouse model;multiple omics;Multivariate Analysis;Mus;next generation sequencing;novel;Phylogenetic Analysis;prenatal;Preparation;Program Research Project Grants;programs;protective effect;recruit;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Risk;Sampling;Schools;Scientist;Shapes;sound;Statistical Computing;Statistical Data Interpretation;statistical learning;Statistical Methods;Statistical Study;statistics;Systems Development;Technology;tool;transcriptome sequencing;web app;Wheezing;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Effects of Indoor Air Pollution;Human Genome;Lung;Microbiome;Pediatric;Prevention

PROJECT_TERMS: 17q;Admixture;Affect;Age;Age Months;age related;Arizona;Asthma;Biological;Birth;Cells;Characteristics;Child;Child Development;Childhood;Childhood Asthma;Chromosomes;Chronic Disease;cohort;cytokine;Data;Day Care;Development;disorder risk;DNA Methylation;drinking water;Dust;early childhood;early life exposure;Environment;Environmental Exposure;Epigenetic Process;epigenome;Exposure to;Farm;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genomic locus;Goals;gut colonization;gut microbiome;gut microbiota;Home environment;House Dust;Immune;Immune response;Immune system;Immunity;Immunologics;Infant;Infant Development;Inflammation;innovation;Life;Link;Livestock;Locales;Location;maternal microbiota;Measures;Mediating;methylation pattern;Mexican;Mexican Americans;Mexico;Microbe;microbial;microbial colonization;microbiome;microbiome research;microbiota;microbiota composition;Modality;Mothers;multiple omics;Neonatal;neonate;Outcome;Participant;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;pet animal;Phenotype;Population;prenatal;Preventive;prospective;recruit;respiratory;Respiratory Tract Infections;response;Rhinovirus;Ribosomal RNA;Risk;risk variant;Schools;single cell analysis;Source;Systems Development;Testing;Third Pregnancy Trimester;transcriptome;Umbilical Cord Blood;Urban Population;urban setting;Vagina;vaginal microbiota;Variant;Water;Wheezing

PROJECT_TITLE: Microbiome Influences on Asthma-Related Outcomes in Early Life


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: LYNCH, SUSAN VERONICA (contact)

PROJECT_TERMS: 2 year old;Allergic;Arizona;Asthma;atopy;Bacteria;Biological Assay;Birth;Border Community;Border Crossings;Cells;Childhood;Childhood Asthma;cohort;Data;Development;Disparate;Disparity;drinking water;Electrical Resistance;Environment;Environmental Exposure;Epithelium;Exhibits;experience;Feces;fetal;FOXP3 gene;Frequencies;Genes;Genetic;gut inflammation;gut microbiome;gut microbiota;high risk;high risk infant;House Dust;Human;IgE;IL4 gene;Immune;immune function;Immunity;immunological status;immunoregulation;in utero;In Vitro;infancy;Infant;Infant Development;infant gut microbiome;Inherited;Intestines;Life;Location;maternal microbiome;Meconium;Medicine;member;Metabolic;Metabolic dysfunction;metabolomics;Metagenomics;Mexican;Mexico;Microbe;microbial;microbial composition;microbiome;microbiome alteration;microbiome components;microbiome composition;microbiome research;microbiota;Mothers;mouse model;Nature;Neonatal;neonate;Newborn Infant;offspring;Outcome;Pattern;peer;Population;pregnant;prenatal;Preparation;Prevalence;Production;Relative Risks;Residencies;Resolution;Ribosomal RNA;Risk;Sampling;Shotguns;Source;stool sample;T-Lymphocyte;Testing;transcriptome sequencing;transmission process;Vagina;vaginal microbiota;water sampling;Water Supply;Wheezing;Woman

PROJECT_TITLE: Divergent Functional and Metabolic Development of the Infant Microbiome


NIH_SPENDING_CATS: Asthma;Clinical Research;Health Effects of Indoor Air Pollution;Lung;Microbiome;Pediatric;Social Determinants of Health

PI_NAMEs: VERCELLI, DONATA  (contact)

PROJECT_TERMS: Affect;Allergic;Amish;Asthma;asthma model;Characteristics;Child;Childhood Asthma;Data;Development;drinking water;Dust;Environment;Environmental Exposure;Environmental Impact;Exhibits;Exposure to;Extrinsic asthma;Farm;Feces;Female;Genes;germ free condition;Germ-Free;gut microbiome;gut microbiota;Home;host microbiome;House Dust;human model;hutterite;Immune;Immune response;in vivo;Individual;Infant;Inhalation;innovation;Life;Link;Location;Meconium;Metabolic;metabolic profile;Metabolism;Mexican;Mexico;Microbe;microbial;microbial composition;microbiome research;microbiota;Mothers;Mus;neonate;novel;Nursery Schools;Output;Pathway interactions;Phenotype;Population;pregnant;Pregnant Women;Prevalence;Pulmonary Inflammation;response;Sampling;Shapes;Side;Testing;Time;trait;Vertical Transmission;Woman;Work

PROJECT_TITLE: Impact of the Environment and Host Microbiome on Asthma Development: Mechanistic Studies


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: During obesity, visceral fat tissue expands causing oxidative stress and the release of pro-inflammatory cytokines that can cause insulin resistance and cardiovascular complications. This project explores the antioxidant bilirubin in molecular detail as a signaling molecule to reduce adiposity and insulin resistance and improve metabolic health. A comprehensive investigation of the signaling preferences for bilirubin may open new avenues for potential new therapeutics for obesity and insulin resistant diabetes, and for cardiovascular diseases in humans.

PI_NAMEs: HINDS, TERRY D (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adenovirus Vector;Adipocytes;Adipose tissue;Adult;Affect;Antioxidants;Attenuated;Bile fluid;Bilirubin;Biliverdin reductase;Biliverdine;Binding;Blood;Blood Glucose;Body Weight;Body Weight decreased;carbohydrate metabolism;Cardiovascular Diseases;Cardiovascular system;Cell Size;clinically relevant;comparison control;cost;Crigler-Najjar Syndrome;cytokine;Data;Deposition;Diabetes Mellitus;Energy Intake;Energy Metabolism;Enzymes;Event;Excretory function;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fenofibrate;fibroblast growth factor 21;Genes;Genetic;Genetic Polymorphism;Gilbert Disease;Glucose;Glucose Intolerance;Health;Health Expenditures;Hepatic;Hepatocyte;Hepatotoxicity;High Fat Diet;hormonal signals;Hormones;Human;humanized mouse;Hyperbilirubinemia;Icterus;improved;Inflammatory;Inherited;Insulin;Insulin Resistance;insulin sensitivity;Intestines;Investigation;Knock-out;Knockout Mice;Knowledge;Ligands;lipid metabolism;Lipids;Liver;Liver diseases;LoxP-flanked allele;Measures;Mediating;Metabolic;Metabolic hormone;Metabolism;microRNA delivery;MicroRNAs;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear Receptors;Obese Mice;obese patients;Obesity;Obesity associated disease;Obesity Epidemic;Outcome;Overweight;oxidation;Oxidative Stress;Pathologic;Pathway interactions;Patients;Peripheral;Peroxisome Proliferator-Activated Receptors;Physiological;Plasma;Population Study;PPAR alpha;preference;Process;promoter;Protein Isoforms;Publications;recruit;Resistance;Risk;Rodent;Serum;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Testing;Therapeutic;Tissue Expansion;Tissues;Transactivation;transcription factor;UDP-Glucuronosyltransferase 1A1;Uncertainty;United States;Visceral fat;Weight Gain

PROJECT_TITLE: Novel Liver Signaling Pathways Controlling Adiposity

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Long-acting, injectable Cabotegravir (LAI CAB) HIV pre-exposure prophylaxis (PrEP) has the potential to prevent HIV among those who experience barriers to effective use of daily, oral PrEP, including many adolescents and young adults (AYA) in sub-Saharan Africa who remain at highest risk of HIV incidence. Disappointing, inequitable outcomes from the initial roll-out of oral PrEP globally and limited utilization of promising injectable formulations in other disease areas demonstrate that implementation success is far from certain, however. This study will identify LAI CAB health system implementation opportunities, measure HCW and AYA implementation preferences, identify preference heterogeneity, and specify implementation strategies to optimize LAI CAB impact in Zambia and globally.

PI_NAMEs: BERES, LAURA  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adolescent and Young Adult;Affective;Africa South of the Sahara;AIDS prevention;Area;career development;Clinical Trials;Cognitive;Collaborations;Competence;Contraceptive methods;Data Collection;Development;Disease;Educational Status;evidence base;experience;experimental study;Formulation;Future;Goals;Health Personnel;Health system;Heterogeneity;high risk;high risk population;HIV;implementation evaluation;implementation science;implementation strategy;Incidence;Infectious Diseases Research;Injectable;innovation;Institution;International;Internet;Intervention;Knowledge;Low income;Maps;Measures;Mentored Research Scientist Development Award;Mentors;novel;Oral;outcome disparities;Population;pre-exposure prophylaxis;preference;prevent;preventive intervention;Process;Productivity;Protocols documentation;recruit;Research;research and development;Research Personnel;Resource-limited setting;Scientist;skills;Specific qualifier value;success;Time;Training;Zambia

PROJECT_TITLE: Optimizing implementation of long-acting, injectable Cabotegravir for HIV prevention among adolescents and young adults in Zambia


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: BIZON, CHRISTOPHER ;BRUSH, MATTHEW H. (contact);MUNGALL, CHRISTOPHER J

PROJECT_TERMS: Agreement;Algorithms;Aloral;Architecture;Autonomous Relay Agent;Biological;biomedical ontology;Collaborations;collaborative environment;Communication;Communities;Computer software;Consensus;Data;data lake;data modeling;data standards;design;Development;Disease;Documentation;Ensure;Infrastructure;innovation;Investments;Knowledge;knowledge graph;Libraries;Maps;Modeling;National Center for Advancing Translational Sciences;Nature;next generation;novel strategies;Ontology;Pharmaceutical Preparations;Phenotype;Process;Protocols documentation;Provider;Registries;Resources;Services;Source;Specific qualifier value;Standardization;System;Testing;Update;Validation;Voting;Work

PROJECT_TITLE: A Common Dialect for Infrastructure and Services in Translator


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cardiovascular;Heart Disease;Lung;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The origins of sex-based differences in ionizing radiation (IR) response remain unclear, potentially involving hormones, genetics, and metabolism. Preliminary mouse model studies hint at sex-specific shifts in nitro-oxidative pathways and mitochondrial superoxide dismutase activities as contributors to sex-specific IR-induced cardio-pulmonary toxicities. This proposal delves deeper into these mechanisms, providing insights into gender-specific factors and potential therapeutic approaches for mitigating IR-induced cardio-pulmonary toxicities.

PI_NAMEs: ALLEN, BRYAN ;LONDON, BARRY  (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: 3-nitrotyrosine;Accidents;Anabolism;Animal Experimentation;Arrhythmia;atomic bomb;Blood Vessels;Cancer Patient;Cardiac;Cardiopulmonary;Cell Aging;Cell Respiration;Cessation of life;Chernobyl Nuclear Accident;Chest;Clinical;Clinical Trials;Complex;Coronary Arteriosclerosis;coronary fibrosis;Data;Diastolic heart failure;Disease;Disparity;Dose;effectiveness evaluation;efficacy evaluation;Electrocardiogram;Electron Transport;epidemiologic data;Exhibits;experience;Exposure to;Face;Female;Fibrosis;Foundations;Functional disorder;Future;Gender;Genetic;Health;Heart;Heart Diseases;Heart failure;Heart Valves;Heterozygote;Hormones;Impairment;Incidence;Individual;Inflammation;insight;Investigation;Ionizing radiation;irradiation;Knockout Mice;Knowledge;Lead;Left;Left ventricular structure;Link;Lung;male;Malignant neoplasm of thorax;Malignant Neoplasms;Manganese;Measures;Mediating;Metabolic;Metabolism;MicroRNAs;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mortality;mouse model;Mus;Myocardial dysfunction;Myocardium;Nitric Oxide;Nitric Oxide Synthase Type I;novel therapeutic intervention;Nuclear Accidents;Organ;Oxidation-Reduction;Oxidative Stress;Oxygen;Pathway interactions;pericardial sac;Pericarditis;Play;pre-clinical;Predisposition;premature;prevent;Pulmonary Fibrosis;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;radiation mitigation;Radiation Pneumonitis;radiation response;radiation risk;Radiation Sicknesses;Radiation Tolerance;Radiation Toxicity;Radiation-Induced Cancer;Reactive Nitrogen Species;Reactive Oxygen Species;Reporting;reproductive;Research;Right ventricular structure;Risk;Role;Safety;sex;Sex Differences;Signal Pathway;Signal Transduction;SOD2 gene;Stains;stem;Structure;Study models;Superoxide Dismutase;Superoxides;Survivors;System;Systolic heart failure;Testing;Therapeutic;Therapeutic Intervention;Thoracic Diseases;Tissues;Toxic effect;valvular insufficiency;valvular stenosis;Ventricular;Wild Type Mouse;Woman

PROJECT_TITLE: Sex-dependent Impairment of Nitric Oxide Signaling and Mitochondrial Metabolism in Radiation-Induced Cardio-Pulmonary Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MR-I (M1)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The goal of the Advanced Training in Urologic Oncology program is to provide MD or MD/PhD urologic oncology fellows the skillset to pursue independent academic careers in cancer-focused research. Graduates of this program will contribute to the advancement of knowledge in the prevention, diagnosis and treatment of cancer.

PI_NAMEs: PALAPATTU, GANESH S (contact);SHAHINIAN, VAHAKN B

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Training;Urologic Oncology

PROJECT_TITLE: Advanced Training in Urologic Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;HIV/AIDS;Infectious Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative HIV is a serious, chronic infectious disease, and understanding the effect of different anti-retroviral treatment strategies is critical to maintaining a person’s overall health and retention in care. Additionally, there is a growing concern that certain antiretroviral medications increase the risk of weight gain and non-communicable diseases such as hypertension, and type 2 diabetes mellitus (diabetes), but the causal effect is not well elucidated. The goal of the proposed research aims is to better understand the effects of different treatment strategies on retention in care, viral suppression, and the risk of weight gain and developing other co- morbidities.

PI_NAMEs: ZHENG, AMY  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Address;Adult;Affect;Anti-Retroviral Agents;antiretroviral therapy;Attention;Binding;care outcomes;Caring;Chronic;Client;Clinic;Clinical;clinical care;Clinical Treatment;Clinical Trials;co-infection;cohort;Collaborations;Communicable Diseases;comorbidity;Data;demographics;design;Development;Diabetes Mellitus;diabetes risk;Disease;efavirenz;Ensure;Epidemiologic Methods;Epidemiologist;Epidemiology;experience;Goals;Guidelines;Health;health assessment;High Prevalence;HIV;HIV Infections;Hypertension;improved;inhibitor;insight;Integrase;Investigation;Laboratories;Learning;Life Expectancy;Literature;low and middle-income countries;Measures;Mentors;Mentorship;Methods;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nucleosides;Outcome;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Policies;poor health outcome;Population;Program Effectiveness;programs;prospective;Prospective cohort;Province;Public Health;Quality of life;randomized trial;Recommendation;Recording of previous events;Regimen;Research;Residual state;Reverse Transcriptase Inhibitors;Risk;scale up;Selection Bias;Severities;Side;Source;South Africa;South African;standard of care;Techniques;Time;Training;treatment comparison;treatment effect;Treatment outcome;treatment program;Treatment Protocols;treatment risk;treatment strategy;Update;Viral;Viral Load result;Weight Gain;Work;World Health Organization

PROJECT_TITLE: Impact of Dolutegravir on Viral Suppression, Retention, and Risk of Non-Communicable Diseases among Persons Living with HIV in South Africa.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-H (20)]