NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative APOE4 is the major genetic risk factor for Alzheimer’s disease (AD), however we do not fully understand how APOE4-driven endolysosomal trafficking defects influence disease risk in human AD brain cells. The goal of this project is to understand the molecular mechanisms of APOE4 lipid-endolysosomal trafficking defect in human astrocytes and identify targets that can reverse the phenotype. Human iPSC-based model application and the knowledge gained from this proposal will be essential to the development of novel AD therapeutic modalities.

PI_NAMEs: TCW, JULIA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acute;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Apolipoprotein E;apolipoprotein E-4;astrocyte progenitor;Astrocytes;Autophagocytosis;Autopsy;autosome;base editing;Biological Models;BODIPY;Brain;brain cell;brain endothelial cell;causal variant;cell type;Cholesterol;cholesterol biosynthesis;chronic demyelination;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR/Cas technology;Cuprizone;Data;Defect;Dementia;Demyelinations;Development;Disease;disorder risk;droplet sequencing;Drug Targeting;effective therapy;endophenotype;Endosomes;Excision;Exhibits;Functional disorder;Future;Genes;genetic risk factor;Genetic Screening;Genetic Transcription;genetic variant;genome wide association study;Genotype;Goals;Guide RNA;Human;human induced pluripotent stem cells;Immunodeficient Mouse;Impairment;In Vitro;in vivo;Intracellular Accumulation of Lipids;knock-down;Knock-out;Knowledge;Label;Late Onset Alzheimer Disease;lipid transport;Lipids;Longitudinal Studies;loss of function;Lysosomes;Measures;Mediating;Metabolic;Microglia;Modality;Modeling;Molecular;Molecular Chaperones;Myelin;Nerve Degeneration;Neuroglia;neuropathology;NFIA gene;novel;Organelles;Pathogenesis;Pathology;Pathway interactions;Phagocytes;Phagocytosis;Phagosomes;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Process;progenitor;Regulator Genes;remyelination;Reporter;Research Project Grants;Risk;risk variant;RNA library;screening;Series;single-cell RNA sequencing;stem cell model;Symptoms;System;targeted treatment;Testing;Therapeutic;trafficking;transcription activator-like effector nucleases;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transfection;Treatment Efficacy;uptake;Variant;Western Blotting;Xenograft procedure

PROJECT_TITLE: Elucidating endolysosomal trafficking dysregulation induced by APOE4 in human astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SANZ, IGNACIO E. (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative: The erythropoietic and prothrombotic effects of Erythropoietin in anemic patients implicates the Megakaryocytic- Erythroid progenitor as a direct target, and a useful model to explore mechanisms that uncouple the production of erythroid and platelet-producing megakaryocytic cells. This application describes a small, discrete, well-defined project to identify candidate proteins and target genes that propagate phenotypic and functional changes downstream of Erythropoietin signaling in human hematopoietic progenitors destined to give rise to erythrocytes and platelets. Results from the proposed studies will improve our understanding of the mechanisms of action of Erythropoietin in human bone marrow leading to advancements in treatments for anemia, and will support the lab during transition to independence by generating preliminary data for a future R01 application.

PI_NAMEs: SCANLON, VANESSA M. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Adult;Affect;Anemia;Apoptotic;Attention;Blood Platelets;Bone Marrow;candidate identification;CD34 gene;cell type;Cells;Chronic;Chronic Kidney Failure;Colony-Forming Units Assay;combat fatigue;cytokine;Cytokine Receptors;Data;Development;dimer;Disparate;effective therapy;EPOR gene;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Erythropoietin;Erythropoietin Receptor;Flow Cytometry;Foundations;Fracture;Funding;Future;Genes;Genetic Transcription;Hematopoietic;Hematopoietic stem cells;Hour;Human;Hypoxia;Image;Immunophenotyping;improved;Injections;Intervention;Kidney;Knowledge;MAP Kinase Gene;Measures;Mediating;Mediator;Megakaryocytes;mimetics;Modeling;Molecular Mechanisms of Action;Molecular Target;Names;novel;Output;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;PI3K/AKT;polypeptide;Population;Production;progenitor;Proliferating;Proteins;Publishing;receptor;Receptor Activation;Receptor Signaling;Renal function;repaired;Research;response;Risk;Role;self-renewal;Signal Pathway;Signal Transduction;stem cell expansion;stem cell population;Stroke;stroke risk;System;targeted treatment;Testing;thrombocytosis;Thrombopoiesis;Tissues;Transfusion;United States

PROJECT_TITLE: Investigating the Cell Type- and Receptor-Specific Effects of Erythropoietin that Mediate Erythropoiesis and Thrombopoiesis in Primary Human Hematopoietic Progenitor Cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Project Narrative The proposed studies aim to elucidate the pathogenesis, particularly that involving the innate and adaptive immune mechanisms, in glaucoma — a debilitating eye disease affecting 80 million people worldwide. Results from completing the proposed studies may reveal new directions in developing mechanism-based diagnostics, prevention and treatment.

PI_NAMEs: CHEN, DONG FENG  (contact);CHEN, JIANZHU ;SHEN, LUCY Q

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Age;Antigens;Attenuated;Automobile Driving;Axon;axon injury;axonal degeneration;Biological Markers;Blindness;Brain;CD4 Positive T Lymphocytes;Cell Count;cell injury;cell type;Cells;Central Nervous System;Clinical;Collaborations;commensal microbes;Deterioration;Development;Diagnosis;Diagnostic;Disease;driving force;Ear;Event;Exhibits;extracellular;Eye;Eye diseases;Frequencies;Germ-Free;Glaucoma;glial activation;Heat shock proteins;HSPB1 gene;Human;Immune;Immune response;Immune Tolerance;immunogenic;Immunologic Markers;Individual;Inflammation;Inflammatory;Inflammatory Response;Inherited;Innate Immune Response;Interferon Type II;intravitreal injection;Link;Massachusetts;Mediating;Medical;Microglia;Modeling;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;Optic Nerve;Pathogenesis;Pathogenicity;Patients;peripheral blood;Persons;Phase;Physiologic Intraocular Pressure;Pilot Projects;Prevention;Primary Open Angle Glaucoma;Productivity;progressive neurodegeneration;protein expression;Recording of previous events;Regulatory T-Lymphocyte;Reporting;Research Personnel;Research Proposals;response;Retina;retinal damage;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Signal Induction;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Specialist;Spinal Cord;Stress;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Up-Regulation;Vision;Visual Fields

PROJECT_TITLE: Innate and Adaptive Immunity in the Pathogenesis of Glaucoma


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Neuropathic pain is a debilitating form of chronic pain afflicting millions of patients worldwide but is poorly responsive to current analgesic therapies. Recent preclinical behavioral data implicates the lateral parabrachial nucleus of the brainstem in the maintenance of both the behavioral reflexive and affective components of neuropathic pain. This study uses in vivo and awake moving fiber photometry and in situ fluorescent hybridization, intraparabrachial pharmacology and chemogenetics, and anatomical tracing combined with efferent terminal chemogenetic inhibition to ultimately determine if excitatory lateral parabrachial neurons (those that contain the type 1 receptor for neuropeptide Y) contribute to the behavioral manifestations of neuropathic pain.

PI_NAMEs: ALLEN, HEATHER NOEL (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acetone;Acute Pain;Affect;Affective;Agonist;Amygdaloid structure;Analgesics;anatomical tracing;Anatomy;Animals;awake;Behavior;Behavioral;Behavioral Symptoms;Bilateral;Brain;Brain region;Brain Stem;Calcium;Cannulas;career;Cell Nucleus;Chronic;chronic pain;chronic painful condition;Clozapine;Complex;conditioned place preference;Cues;Data;Development;Disease;Emotional;excitatory neuron;experimental study;Family;Fiber;Fluorescence;Fluorescent in Situ Hybridization;Formalin;Future;General Population;Genetic;Glutamates;Gossypium;healing;heat stimulus;Hypersensitivity;Hypothalamic structure;Implant;In Situ;In Situ Hybridization;in vivo;Infusion procedures;Injury;insight;Laboratories;Lateral;Lesion;Light;Maintenance;Measures;Mechanics;midbrain central gray substance;Modeling;Molecular;Motor;Mus;nerve injury;Neurons;Neuropathy;neuropeptide Y;Neuropeptide Y Receptor;neuropeptide Y-Y1 receptor;Neuropeptides;Nociception;Nociceptors;Opioid;Oxides;Pain;pain signal;painful neuropathy;parabrachial nucleus;Pathologic;Patients;Pattern;Peripheral;peripheral nerve damage;Peripheral nerve injury;Persistent pain;pharmacologic;Pharmacology;Photometry;Pontine structure;pre-clinical;preference;Publications;Publishing;Quality of life;receptor;Research Personnel;response;Rodent Model;Role;Sensory;sensory stimulus;skills;Societies;somatosensory;spared nerve;Stimulus;Structure;Structure of paraventricular nucleus of thalamus;Structure of terminal stria nuclei of preoptic region;Surgical Injuries;Swab;System;Taste aversion;Testing;Therapeutic;Tissues;United States;Veins;Viral;Virus;Withdrawal;Writing

PROJECT_TITLE: Neuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic Pain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative This project is aimed at understanding the structure and function of a large number of helical protein and nucleoprotein filaments, ranging from actin in human muscle to helical viruses that infect organisms living in nearly boiling acid. Some of the studies are likely to have a direct and immediate impact on human health, such as those involving the bacteria responsible for meningitis and food poisoning, while others will have longer range impact including new tools for biotechnology.

PI_NAMEs: EGELMAN, EDWARD H. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: This is a diversity supplement to provide training to a postbaccalaureate researcher, Mr. Sebastian Lopez, so that he will be more competitive for getting into graduate school and more successful as a researcher.

PI_NAMEs: LUCK, STEVEN J (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Algorithms;Architecture;Area;Attention;base;Behavior;behavior prediction;Behavioral;Brain region;Categories;Classification;Code;Color;Complex;Computer Models;Consensus;convolutional neural network;Data;design;Detection;Electroencephalography;Event-Related Potentials;experimental study;Eye Movements;Face;feeding;Frequencies;Functional Magnetic Resonance Imaging;Goals;graduate school;Grant;Human;human subject;Individual Differences;insight;Learning;Life;Literature;Location;machine vision;Measures;Memory;Modeling;Nature;neural;Neural Network Simulation;neural patterning;Neurons;Neurosciences;Noise;object recognition;Pathway interactions;Pattern;Perception;Performance;Persons;Play;Population;Postbaccalaureate;Primates;Property;Proxy;Reporting;Research;Research Personnel;response;Role;Sampling;Short-Term Memory;Specific qualifier value;Stimulus;Structure;Surface;System;Testing;theories;Training;vector;ventral visual stream;verbal;Vision;Visual;Visual Perception;visual search;Vocabulary

PROJECT_TITLE: Supplement:Using population vectors to understand visual working memory for natural stimuli


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Immunotherapy;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE iGL-VRC01 B cells from KI mice will be activated in vitro and adoptively transferred into WT animals to generate higher than normal frequencies of antigen speciﬁc memory B cells with different important memory phenotypes. These cells will be vaccinated with high to low afﬁnity and valency immunogens and the responses generated from memory B cells will be assessed. This study will complement previous work with naive iGL-VRC01 cells and their responses to similar panels of immunogens.

PI_NAMEs: VOSS, JAMES EVEN (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Adoptive Transfer;Affinity;Animals;Antigens;Area;B-Cell Activation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Behavior;cell behavior;Cell Compartmentation;Cell surface;Cells;Clonal Expansion;Complement;Data;Development;Engineering;Engraftment;experimental study;Frequencies;Goals;HIV Receptors;Human;Immunize;improved;In Vitro;Infection;Knock-in;Knock-in Mouse;Memory;Memory B-Lymphocyte;mouse model;Mus;neutralizing antibody;parent project;Parents;Phenotype;preference;programs;Reaction;Research;response;Secondary to;Shapes;Structure of germinal center of lymph node;success;T-Lymphocyte;Testing;TNFSF5 gene;Vaccinated;Vaccination;vaccination strategy;Vaccine Design;Vaccines;Work

PROJECT_TITLE: Characterization of iGL-VRC01 Memory B cell Responses in Mice

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Aging is often accompanied by cognitive deficits and is also the major risk factor for Alzheimer's disease (AD). This multi-component research program studies a rodent model of naturally occurring variation in cognitive aging, with the goal of understanding the neurobiological basis of impairment and preservation of brain function that could contribute to vulnerability and resilience, respectively, in AD. Building on existing therapeutic progress, work within this program will continue to contribute to the development of effective therapeutic interventions for cognitive decline in aging with potential for slowing late-onset AD progression in its earliest phases.

PI_NAMEs: GALLAGHER, MICHELA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Achievement;Address;Affect;Age;age difference;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;animal old age;animal resource;Animals;Basic Science;Behavioral;Bioinformatics;Biological;Brain;Cells;Clinical;clinical investigation;Clinical Research;clinical translation;Cognition;Cognitive;Cognitive aging;cognitive capacity;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;Coupled;data integration;data management;Dependence;Development;Disease Progression;entorhinal cortex;Episodic memory;Equilibrium;excitatory neuron;Exhibits;experience;Experimental Designs;experimental study;Failure;falls;Female;foot;gain of function;Goals;Hippocampal Formation;Hippocampus;Homeostasis;Human;human imaging;human old age (65+);Impaired cognition;Impairment;improved;in vivo imaging;Individual;Individual Differences;innovative technologies;insight;Interneurons;Intervention;Knowledge;Knowledge acquisition;Laboratory Animals;late life;Late Onset Alzheimer Disease;Lateral;Long-Evans Rats;loss of function;Macaca mulatta;male;Memory;Memory impairment;Methods;Mission;Modeling;multidisciplinary;neural;neurobehavioral;Neurobiology;Neurocognitive;normal aging;novel;Outcome;Parvalbumins;Pathway interactions;Performance;pharmacologic;Phase;Population;preservation;programs;Publications;Rattus;receptor;Research;Research Personnel;resilience;Risk;Rodent;Rodent Model;Role;Sex Differences;Site;slow potential;Statistical Data Interpretation;statistics;Stream;study population;Support System;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;tool;Translating;translation to humans;Translations;Variant;Work;young adult

PROJECT_TITLE: Cognition & Hippocampal/Cortical Systems in Aging


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PI_NAMEs: BEASLEY, DAVID  (contact)

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Basic Science;Contracts;Coronavirus Infections;COVID-19 test;Development;Evaluation;Human;Lung;microphysiology system;Modeling

PROJECT_TITLE: Task C14: Advancing Human Lung Microphysiological Systems to Model Coronavirus Infection and Test Candidate Countermeasures


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: WU, XIAO-CHENG  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PI_NAMEs: DURBIN, ANNA PALMER (contact)

PROJECT_TERMS: Clinical Trials;Dengue;Dengue Vaccine;Development;Drug Kinetics;efficacy evaluation;Participant;Phase;Safety;vaccine candidate

PROJECT_TITLE: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, DOSE-RANGING STUDY TO COMPARE THE SAFETY AND EFFICACY OF 3 DOSE LEVELS OF AV-1 IN HEALTHY ADULTS CHALLENGED WITH A CONTROLLED HUMAN INFECTION S


ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT STATE DEPT OF PUBLIC HEALTH

PI_NAMEs: MUELLER, LLOYD  (contact)

PROJECT_TITLE: SEER Core Infrastructure Support


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Arrhythmogenic cardiovascular disease and sudden cardiac death disproportionately affect VA patients with acquired cardiovascular disease, such as heart failure. Nationally, there are more than 350,000 VA patients who carry the diagnosis of heart failure. In the St. Louis VA system alone, over 3,000 patients have heart failure with reduced ejection fraction and an equal, if not greater, number of patients have heart failure with preserved ejection fraction. Following hospitalization, VA heart failure patients have a 22% chance of being re-admitted for worsening heart failure and 9% chance of dying within 30 days. It is increasingly recognized that the paucity of electrophysiological studies on the human heart has been a persistent barrier to advances in heart failure diagnosis and treatment. Here, we propose a powerful experimental strategy to identify the electrophysiological signature and the molecular determinants of human heart failure-related arrhythmogenic cardiovascular disease, information that will reveal new targets to treat heart failure and new strategies to prevent sudden death.

PI_NAMEs: BALKE, C. WILLIAM;NERBONNE, JEANNE M. (contact)

PROJECT_TERMS: Action Potentials;adenoviral mediated;Affect;Animal Experimentation;Animal Model;Animals;Arrhythmia;Attenuated;Automobile Driving;Biochemical;Biophysics;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiovascular Diseases;Cell surface;cell type;clinically relevant;Critical Pathways;Diagnosis;differential expression;Disease;EFRAC;Electrophysiology (science);Experimental Animal Model;Experimental Designs;experimental study;extracellular;Family;Foundations;Functional disorder;Goals;Health Care Costs;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart rhythm;hospital readmission;Hospitalization;Human;human induced pluripotent stem cells;In Vitro;indium arsenide;Individual;Infrastructure;insight;Knowledge;Left;Left ventricular structure;Life;Maintenance;Membrane;Metabolic Diseases;Methods;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardium;new therapeutic target;novel;Pathway interactions;patient stratification;Patients;pharmacologic;Phase;Physiological;Physiology;Play;Population;Post-Translational Protein Processing;preservation;prevent;Procedures;programs;Property;Public Health;Quality of life;Regulation;Research;Resources;Risk;Risk Reduction;risk stratification;RNA;Role;Shapes;sudden cardiac death;Sudden Death;System;targeted treatment;Testing;Tissues;transcriptomic profiling;Translating;Ventricular;Ventricular Arrhythmia;voltage

PROJECT_TITLE: Identification of Novel Cellular/Molecular Mechanisms and Arrhythmia Targets in Heart Failure


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative My studies will provide a more detailed understanding of a signaling pathway regulating atrial fibrosis in atrial fibrillation development. In the long term, I aim to apply my findings as a candidate for a novel gene therapy approach to reduce atrial fibrosis in atrial fibrillation. Since atrial fibrillation is an increasingly prevalent disease with excessive atrial fibrosis being a common driver, my studies could enable a more targeted and definitive treatment for atrial fibrillation that would improve the quantity and quality of life for millions of patients in the United States.

PI_NAMEs: HO, KEVIN SON (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adherent Culture;Affect;Alleles;Animal Model;Arrhythmia;Atrial Fibrillation;Basic Science;Biological Assay;Bromodeoxyuridine;Calcitonin;Calcitonin Receptor;Cardiac Myocytes;career;Cessation of life;Clinic;clinical practice;Clinical Skills;Collaborations;Collagen;Collagen Fiber;Complex;CRISPR/Cas technology;Data;Dedications;Dependovirus;Deposition;Development;Disease;Down-Regulation;Electrocardiogram;Electrophysiology (science);Ensure;Environment;Enzymes;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;gene therapy;Goals;graduate school;Heart;Heart Atrium;Histology;Human;immunocytochemistry;improved;in vivo;interstitial;knock-down;Knock-out;latent TGF-beta binding protein;Learning;Maps;Mediating;Mediator;Medical center;Mentors;migration;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;novel;Operative Surgical Procedures;Optics;Oranges;overexpression;Paracrine Communication;Pathway interactions;Patient Care;Patients;Peptide Hydrolases;Peptides;Persons;Physicians;Postdoctoral Fellow;Production;Profibrotic signal;Proliferating;Proteins;Quality of life;Receptor Activation;Regulation;Research;Resistance;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;skills;System;Telemetry;Testing;Texas;therapy resistant;Training;Transforming Growth Factor beta;United States;Western Blotting;Zinc

PROJECT_TITLE: Targeting the Calcitonin-BMP1 Pathway in Atrial Cardiofibroblasts to Ameliorate Atrial Fibrillation


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Digestive Diseases;Genetics

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: NARRATIVE Gastric parietal cell dysfunction underlies a wide range of human diseases associated with a high socioeconomic burden including chronic gastritis, peptic ulcer disease, and cancer. Given the essential role for parietal cells in maintaining a healthy stomach, it is surprising that a comprehensive understanding how the program regulating and maintaining normal parietal cell development and function, and thereby parietal cell health and overall gastric epithelial cell health, is incomplete. This study will investigate the role of the transcription factor GATA4 in fundamental aspects of parietal cell function with the goal of applying findings to gastric disease.

PI_NAMEs: BATTLE, MICHELE A (contact);RAO, SRIDHAR

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acids;Address;Affect;Atrophic;Automobile Driving;Back;Binding;Biology;Cancer Etiology;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cellular biology;Cessation of life;Chemicals;Chief Cell;Chronic Gastritis;clinical application;cofactor;Data;Development;Diagnosis;Digestion;Disease;Economic Burden;Enhancers;Epithelial Cells;Epithelium;experience;Foundations;Functional disorder;Future;Gastric Acid;Gastric Glands;gastric organoids;Gastric Parietal Cells;Gastric Tissue;Gastritis;GATA4 gene;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Growth Factor;Health;Helicobacter Infections;Helicobacter pylori;Homeostasis;Human;human disease;Hypermethylation;Infection;Injury;insight;interest;Knock-in;Knowledge;Malignant Neoplasms;malignant stomach neoplasm;Metaplasia;Modeling;Molecular;Morphology;mouse model;Mus;Natural regeneration;novel;Nucleic Acid Regulatory Sequences;Organoids;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peptic Ulcer;Persons;Pharmaceutical Preparations;Phenotype;Play;programs;promoter;Promoter Regions;Proteomics;Repression;Rodent;Role;socioeconomics;Stomach;Stomach Diseases;Testing;tool;Transcriptional Regulation;transgene expression;Ulcer

PROJECT_TITLE: Defining GATA4's Molecular Function in Gastric Cell Biology

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Rheumatoid Arthritis;Vaccine Related

ORG_CITY: Rockville

ORG_NAME: RISE THERAPEUTICS, LLC

PHR: Project Narrative Rheumatoid arthritis (RA) is a progressive, chronic autoimmune disease characterized by inflammation and pain of the joints that afflicts up to as much as 1% of the U.S. population1, 2. This project aims to develop a novel L. lactis synthetic biology medicine programmed to express and deliver colonization factor antigen I (CFA/I) to induce T regulatory cells for the treatment of RA. Successful commercialization would ultimately provide a profound front-line medical advancement in the treatment of RA.

PI_NAMEs: FANGER, GARY  (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: adaptive immune response;Affect;Animal Model;antagonist;Anti-Tumor Necrosis Factor Therapy;Arthralgia;Arthritis;Attenuated;Autoimmune;Autoimmune Diseases;Autoimmunity;Bacterial Infections;Biological;Biological Assay;Biological Markers;Biological Response Modifier Therapy;Blood specimen;bone;C-reactive protein;capsule;Cartilage;Cells;Chemistry;Chronic;chronic autoimmune disease;Clinical;clinical biomarkers;Clinical Research;clinical research site;Clinical Trials;colonization factor antigens;commercialization;confirmatory trial;Consent;cost;cytokine;data management;Dendritic Cell Pathway;design;Development;Diabetes Mellitus;Diarrhea;disabled;Disease;Disease remission;Documentation;Dose;Drug Compounding;Drug Delivery Systems;Drug Kinetics;effective therapy;Effector Cell;effector T cell;Engineered Probiotics;Engineering;Enteral;enterotoxigenic Escherichia coli;Equilibrium;Excipients;Experimental Models;Fermentation;first-in-human;Food;food preparation;Funding;Genetic Engineering;Goals;Homeostasis;Human;Human Volunteers;Iatrogenesis;Immune;Immune response;Immunologics;Immunomodulators;immunoregulation;Immunosuppressive Agents;improved;Inflammation;Inflammatory;Infrastructure;innovation;Intestines;Investments;Label;Lactococcus lactis;life time cost;Malignant Neoplasms;manufacture;manufacturing process;manufacturing scale-up;Measurement;Measures;Mediating;Medical;Medical center;Medicine;microbiome;Modeling;mouse model;Mucous Membrane;Multiple Sclerosis;novel;operation;Opportunistic Infections;Oral;Oral Administration;oral immunotherapy;Organ;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Population;Positioning Attribute;pre-Investigational New Drug meeting;Predisposition;prevent;Probiotics;Production;Property;protein purification;Proteins;Recombinants;Recommendation;Regulatory T-Lymphocyte;Relapse;relapse prevention;research clinical testing;response biomarker;Rheumatoid Arthritis;Risk;Running;Safety;safety assessment;Sampling;scale up;Sjogren's Syndrome;Small Business Innovation Research Grant;stool sample;Study models;Sushi Domain;Symptoms;Synovial joint;synthetic biology;T cell response;targeted treatment;Testing;Therapeutic;Time;Tissues;TNF gene;treatment effect;Up-Regulation;vaccine delivery;vaccine trial;Vaccines;Validation

PROJECT_TITLE: A Novel Immunological-Directed Biotherapy for Treating Rheumatoid Arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE In this grant cycle, we test whether right and left hemisphere temporal regions have different roles in processing the sounds of speech, examining neuroimaging and TMS data from typical controls and behavioral data from individuals with left and right temporal lobe lesions. Understanding the roles of right and left hemisphere regions is key to developing appropriate rehabilitation strategies for people with aphasia.

PI_NAMEs: MYERS, EMILY B (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: The Role of Frontal and Temporal Brain Areas in the Perception of Phonetic Category Structure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Microbiome;Orphan Drug;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Gut microbiota has emerged as a potential mediator, significantly impacting tumor growth and immune response. Here, we have identified specific bacteria species important for hepatocellular cancer (HCC) initiation, progression, and HCC immunotherapy. Successful completion of the proposed studies will provide insight into the underlying cellular and molecular mechanisms and advance gut microbiota-integrated immunotherapy for HCC to clinical application.

PI_NAMEs: LI, GUANGFU ;STAVELEY-O'CARROLL, KEVIN FINNBAR (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Acceleration;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Antibiotics;Area;Bacteria;Bacteroides;Bacteroides thetaiotaomicron;BAY 54-9085;Biological Assay;cancer care;cancer immunotherapy;cancer initiation;Cancer Patient;cancer therapy;Canis familiaris;CD8-Positive T-Lymphocytes;Cell Physiology;chemotherapy;clinical application;Dendritic Cells;DNA;FDA approved;Gastroenterology;genetic approach;Genomic DNA;Goals;Grant;Growth;gut microbiota;Hepatocarcinogenesis;Hepatology;Hepatotoxicity;Human;Human Cancer Pathology;human disease;human microbiota;Imipenem;Immune;immune activation;immune function;Immune response;Immune system;Immune Tolerance;Immunologics;immunoregulation;Immunotherapy;improved;in vivo;insight;Journals;knock-down;Legal patent;Link;Liposomes;Liver;Liver diseases;Macrophage;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Mediator;member;Metagenomics;Microbe;microbiota;Modeling;Molecular;mouse model;Mus;N-caproylsphingosine;nanoliposome;Neomycin;novel;overexpression;Pathology;Pathway interactions;patient response;Patients;Pattern recognition receptor;Phagocytosis;Phase I Clinical Trials;Phase II Clinical Trials;Play;Population;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;Publishing;Research;Resistance;response;Role;Sentinel;single-cell RNA sequencing;Sterilization;Supplementation;SV40 T Antigens;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;transcription factor;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor immunology;tumor progression;Vancomycin

PROJECT_TITLE: Mechanistic studies of gut microbiota-mediated immune activation against hepatocellular cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  As a physician-scientist with demonstrated commitment to understanding the mechanistic underpinnings of right heart failure, I will collaborate with Dr. Felipe Kazmirczak to establish and characterize a novel porcine model of severe tricuspid regurgitation. In Aim 1, we will define how a newly-developed porcine model of severe tricuspid regurgitation alters right heart structure and function using cardiac MRI. In Aim 2, we will perform a multi-omic analysis to define how severe tricuspid regurgitation alters right atrial and right ventricular biology, and then compare these effects to right ventricular pressure overload using specimens collected from our parent R01.

PI_NAMEs: PRINS, KURT W (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Animal Model;Animals;Biology;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cell Nucleus;Collaborations;cost;Data;Death Rate;Development;Disease;Diuretics;Etiology;Evaluation;experience;Family suidae;Female;Heart;Heart Atrium;high risk;Histologic;Hospital Costs;Hospital Mortality;Human;Inferior vena cava structure;insight;Knowledge;male;Mediating;Medical;metabolomics;Modeling;Molecular;molecular phenotype;multiple omics;Mus;novel;Operative Surgical Procedures;parent project;Parents;Pathogenicity;Pathologic;Patients;Physicians;Physiologic intraventricular pressure;Physiology;porcine model;pressure;Prognosis;Proteomics;Pulmonary artery structure;Rattus;repaired;response;Right atrial structure;right ventricular failure;Right Ventricular Function;Right ventricular structure;Rodent;Rodent Model;Scientist;Severities;Specimen;Structure;therapeutically effective;Tissues;transcriptome sequencing;translational model;Tricuspid Valve Insufficiency;Tricuspid valve structure;United States;Venous;Ventricular;Ventricular End-Diastolic Volumes

PROJECT_TITLE: Development of a Porcine Model of Severe Tricuspid Regurgitation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Diabetes;Obesity;Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: TROY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: Project Narrative Bone fractures in type 2 diabetes cannot be accurately predicted by current bone density-based clinical tools as T2D patients exhibit normal to high bone mineral density. This project will establish Carboxymethyl-lysine (CML) as a new biomarker of T2D fracture and determine how the oxidation and glycation processes, associated with diabetes under obese and non-obese conditions, impact accumulation of CML and other Advanced Glycation Endproducts (AGEs) and enhance bone fragility. The results will provide new strategies to diagnose, treat and mitigate T2D and fragility fractures.

PI_NAMEs: VASHISHTH, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Advanced Glycosylation End Products;Affect;Age;Aging;Assessment tool;Biological Assay;Biological Markers;Body Composition;bone;Bone Density;bone fragility;bone loss;Bone Matrix;bone quality;bone toughness;Cadaver;Calcium ion;Charge;Clinical;cohort;Collagen;cortical bone;Diabetes Mellitus;diabetic;Diagnosis;Dominant-Negative Mutation;Etiology;Exhibits;Femur;Fracture;fracture risk;fragility fracture;Glucose;glycation;Glyoxal;Goals;Growth;Health;Health Care Costs;health data;High Fat Diet;high risk;Hip Fractures;Human;Hydroxyapatites;Hyperglycemia;Impairment;In Vitro;in vitro Model;in vivo;Insulin-Like-Growth Factor I Receptor;Length;Link;Lipids;long bone;Measures;mechanical properties;Mechanics;microCT;mineralization;Minerals;MM form creatine kinase;Modification;Molecular;mouse model;Mus;muscle engineering;N(6)-carboxymethyllysine;Natural Products;Non obese;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;oxidation;Oxidative Stress;Patients;pentosidine;Persons;Post-Translational Protein Processing;Predisposition;Process;promoter;Property;Proteins;Quality of life;Reaction;Ribose;Risk;Roentgen Rays;Role;Serum;skeletal;Skin;Specimen;spine bone structure;substantia spongiosa;sugar;Techniques;Testing;Time;Tissues;tool;Type 2 diabetic;Urine

PROJECT_TITLE: Effects of Advanced Glycation Endproducts on Type 2 Diabetic and Fragility Fractures

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: CHESTNUT HEALTH SYSTEMS, INC.

ORG_STATE: IL

PHR: PROJECT NARRATIVE  The highest risk groups for problems stemming from opioid use disorder are (1) public system-involved emerging adults (ages 16-25) and (2) individuals who are justice-involved (including emerging adults). Peer recovery support services and recovery residences are proliferating nationally and may have tremendous benefit for these two high-risk groups, but research on them is limited and lacks scientific rigor. This Initiative is a partnership between advanced researchers, persons in recovery, providers, and payors, with the aim of advancing research on the efficacy/effectiveness of recovery support services for this critical public health issue.

PI_NAMEs: MCCART, MICHAEL R;SHEIDOW, ASHLI J (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Adult;Advocacy;Age;age group;Area;Award;behavior change;career;catalyst;Cause of Death;Communities;community based participatory research;community based research;community collaboration;Consultations;Dedications;design;Development;Drug usage;Educational workshop;Effectiveness;efficacy study;emerging adult;Ensure;Equity;experience;Feedback;Foundations;Funding;Goals;Grant;Growth;Health Services Research;high risk;high risk population;Individual;innovation;Justice;Lead;Measurement;medication-assisted treatment;Mentors;Methods;Mission;Modeling;multidisciplinary;Opioid;opioid use;opioid use disorder;Oregon;Outcome;outreach;Overdose;Paper;peer recovery;Persons;Pilot Projects;Policies;polysubstance use;Population;preference;Prisons;Probability;Problem-Based Learning;programs;Proliferating;Provider;Public Health;Publishing;R24;Recovery;recovery services;Recovery Support;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;residence;Resources;service providers;Services;Site;skills;social cognitive theory;social learning;Statistical Data Interpretation;stem;System;Target Populations;Technology;tool;Training;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Building a Lasting Foundation to Advance Actionable Research on Recovery Support Services for High RiskIndividuals with Opioid Use Disorder: The Initiative for Justice and Emerging Adult Populations


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Palliative Care;Patient Safety;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death). We propose to evaluate, in a randomized clinical trial, a strategy of expanded advance care planning (ACP) to support older adults in value-aligned re- assessment of T2D treatment regimens with their primary care team. If the aims of this project are achieved and incidence of clinically-significant hypoglycemia is reduced, this expanded ACP care strategy could be scaled and applied in a wide variety of healthcare settings and chronic conditions in which evolving risks, benefits, and consequences of treatment require re-assessment with age.

PI_NAMEs: GRANT, RICHARD W (contact);SUDORE, REBECCA L

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adult;Advance Care Planning;advanced directive;Adverse event;adverse outcome;Age;age related changes;Age Years;aged;American;California;Cardiovascular system;Caring;Cessation of life;Chronic;Clinical;clinical effect;Clinical Trials;clinically significant;Communication;comorbidity;Complex;Complication;contextual factors;cost;Decision Making;diabetes distress;diabetes management;Diabetes Mellitus;Documentation;efficacy evaluation;end of life;Epidemic;Event;evidence base;Evidence based treatment;experience;falls;Fracture;Future;Glucose;Glycosylated hemoglobin A;Goals;Grant;Health;health care settings;health literacy;Heterogeneity;high risk;Hospitalization;human old age (65+);Hypoglycemia;Impaired cognition;improved;Incidence;Individual;innovation;Insulin;Intervention;Kidney Failure;Life;Managed Care Programs;Medical;Medical center;Medicine;Methods;middle age;mortality;Non-Insulin-Dependent Diabetes Mellitus;older adult;older patient;Older Population;Outcome;Patient Outcomes Assessments;Patient Participation;Patient Preferences;Patient Self-Report;Patients;Patterns of Care;Persons;Pharmaceutical Preparations;Physiology;Population;pragmatic trial;preference;Preparation;Primary Care;primary care provider;primary care setting;primary care team;Provider;Quality of life;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Regimen;response;Risk;Safety;Self Efficacy;skills;Specific qualifier value;success;Sulfonylurea Compounds;support tools;Testing;Time;tool;treatment as usual;treatment effect;Treatment Efficacy;treatment guidelines;Treatment Protocols;treatment risk;usability;Visit;Voice

PROJECT_TITLE: Clinical Trial of Expanded Advance Care Planning to Address Regimen Intensity in Older Patients at High Risk for Treatment-Induced Hypoglycemia

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This three-arm individual randomized controlled effectiveness trial aims to reduce childhood obesity disparities in children ages 5-8 (n=510) from low income and diverse households by increasing family meal quality (i.e., diet quality, interpersonal atmosphere) and quantity (i.e., family meal frequency). Innovative methodology (e.g., ecological momentary assessment (EMI), video feedback) will be used in partnership with primary care clinics and Community Health Workers to test three arms: (1) EMI; (2) EMI+Home Visiting (HV); and (3) EMI+HV+ Video Feedback. Findings will result in a new model for childhood obesity treatment in primary care.

PI_NAMEs: BERGE, JERICA M (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Adult;African American;Age;arm;Atmosphere;Behavior;behavior change;Body mass index;Cellular Phone;Child;clinical practice;Communities;Community Health Aides;community partners;Coping Skills;Cost Analysis;cost effective;cost effectiveness;Data Collection;Diet;dietary;Dietary intake;Disparity;Ecological momentary assessment;Education;effectiveness trial;Eligibility Determination;Environment;Ethnic Origin;Evidence based intervention;Family;Family member;family support;Feedback;feeding;food environment;food quality;Frequencies;Health behavior;Health Technology;Healthy Eating;High Prevalence;Hispanic;Home;Home visitation;Household;implementation intervention;Income;indexing;Individual;innovation;Intervention;intervention effect;Intervention Studies;Longitudinal Studies;Low income;Maintenance;Measures;meetings;Methodology;Methods;mHealth;Minority;Modeling;Native Americans;Obesity;obesity in children;obesity risk;obesity treatment;Outcome;Overweight;Parents;Participant;Pattern;Phase;Pilot Projects;post intervention;Primary Care;primary care clinic;primary care setting;primary outcome;Procedures;Protocols documentation;Race;Randomized;Readiness;recruit;Research;Risk;secondary outcome;Self Efficacy;sex;Siblings;Socioeconomic Status;Stress;success;Systems Theory;Testing;three-arm study;Time;video visit;Visit;Weight

PROJECT_TITLE: Reducing Childhood Obesity Using Ecological Momentary Intervention (EMI) and Video Feedback at Family Meals

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Heart Disease;Mental Health;Physical Activity;Prevention

PHR: PROJECT NARRATIVE The overall project goal is to address the critical need for self-care strategies to improve the physical and psychological health of older family care partners caring for patients with heart failure. This proposed study is relevant to public health because older family care partners often experience high caregiving burden that results in physical function decline, psychological distress, sleep disturbance, and poor health status. Implementation of this project's tailored physical activity coaching program, which uses integrated digital health technologies, will have the potential to support self-management and enhance the health and well-being of aging family care partners.

PI_NAMEs: BAIK, DAWON  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;age related;Aging;attentional control;behavior change;behavioral health intervention;care giving burden;career;caregiving;Caring;Chronic Disease;clinical trial implementation;college;Colorado;Communities;COVID-19 pandemic;design;Development;digital health;Discipline of Nursing;efficacy study;Emotional;Environment;exercise intervention;experience;Family;field study;Foundations;Friends;Goals;Health;Health Promotion;Health Status;Health Technology;Healthcare;Heart failure;Home;improved;Intervention;Interview;Knowledge;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;novel;older adult;Older Population;Outcome;Patient Care;Patients;Perception;Personal Satisfaction;Physical activity;physical conditioning;Physical Function;Population;Population Heterogeneity;programs;psychologic;psychological distress;psychological outcomes;Public Health;Public Health Informatics;Quality of life;Randomized;Research;Risk;Self Care;Self Management;skills;Sleep disturbances;Social support;Technology;Testing;Time;training opportunity;Universities;usability

PROJECT_TITLE: Supplement: Digital Health Physical Activity Program for Older Family Care Partners of Patients with Heart Failure

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: 08 Project Narrative The coordinated firing of millions of neurons in the human brain gives rise to the diverse set of experiences, emotions, thoughts, and sensations that make up the human condition. Despite the central importance of neuronal physiology to human health and disease, our understanding of this complex field remains incomplete due to a lack of tools that can reliably report on membrane potential. This proposed research will develop and apply new optical tools to study neuronal membrane potential in cells and in circuits.

PI_NAMEs: MILLER, EVAN WALKER (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

ORG_STATE: DC

PHR: Project Narrative The Forum convenes approximately 2-3 times a year for Forum member meetings. During the course of Forum discussions the need for more in-depth and detailed discussions on specific topics is likely to emerge. In order to appropriately address these topics, the Forum may sponsor a workshop on topics developed by the Forum membership. In selecting workshop topics, the Forum considers the timeliness of the issues, the amount of information already available on the topic, and whether or not the Forum can offer additional information or breadth of perspectives that would be useful to the discussion on the topic.

PI_NAMEs: BEACHY, SARAH H (contact)

PROGRAM_OFFICER_NAME: MONK, DONNA

PROJECT_TITLE: Forum on Regenerative Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CBER-T (01)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative During cell division, each daughter cell must inherit exactly one copy of each chromosome as errors can lead to cancer and birth defects. Two large cellular machines are responsible for segregating chromosomes: the spindle and kinetochore. Here we probe how these machines’ building blocks together give rise to their function, aiming to uncover the mechanical design principles driving chromosome segregation and to ultimately better target dividing cells for therapeutic purposes.

PI_NAMEs: DUMONT, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acute;Anaphase;Architecture;Automobile Driving;Binding;biophysical techniques;Cell division;Cells;Chromosome Segregation;Chromosomes;Congenital Abnormality;daughter cell;Decision Making;design;Event;Goals;grasp;In Vitro;in vivo;Inherited;innovation;Kinetochores;Knowledge;Malignant Neoplasms;Mammalian Cell;Mammalian Chromosomes;Mechanics;Microtubules;Mitosis;Modeling;Molecular;molecular scale;Needles;optogenetics;physical process;physical property;reconstitution;Role;Shapes;Signal Transduction;Stress;Structure;Testing;Therapeutic;Time;tool;Work

PROJECT_TITLE: Emergent mechanics of mammalian chromosome segregation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Precision Medicine

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: Radiation metabolomics is a well-established field in biomarker discovery and in assessing changes associated with metabolic perturbations, whether in tissues or biofluids. We have developed a rich database of radiation biomarkers in urine, blood, and saliva and we now plan to develop multiplex assays that are highly quantitative and can serve as the first step towards a deployable assay using commercially based instruments. Additionally, we will further develop membrane-based technologies that will aim to eliminate the pre-processing steps, thereby jump-starting the sample processing step and enrichment for specific classes of metabolites and stabilizing the biosignature during transport.

PI_NAMEs: LAIAKIS, EVAGELIA CHRISTOS (contact);ZENHAUSERN, FREDERIC

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biosignature;Blood;Clinical;comparison control;Databases;Devices;Dryness;Emergency Situation;Engineering;Evaluation;experience;flexibility;Generations;Goals;human error;Individual;instrument;Intention;Intervention;Laboratories;Liquid Chromatography;mass casualty;Medical;Membrane;Metabolic;metabolomics;Methods;multiplex assay;Noise;Preparation;Process;Radiation;Radiation Injuries;rapid technique;Resources;Saliva;Sampling;Serum;Signal Transduction;Specificity;tandem mass spectrometry;targeted biomarker;Technology;technology development;Time;Tissues;Urine;Whole Blood

PROJECT_TITLE: Targeted Biomarker Panels and Pre-processing Device for the Rapid Assessment of Radiation Injury in Easily Accessible Biofluids


NIH_SPENDING_CATS: Atherosclerosis;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PHR: PROJECT NARRATIVE Our work focuses on how signaling networks generate complex cellular behaviors such as cell movement and immune cell activation. The ability to control cell migration would be a valuable tool for combating atherosclerosis, inflammation, metastasis, and other pathological processes that occur upon the disruption of cellular guidance mechanisms. Our work on the mechanism of immune cell activation will directly impact our understanding of autoimmune disease, vaccine development, and immunotherapy-based cancer treatments.

PI_NAMEs: WEINER, ORION D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Address;antigen binding;Antigens;Atherosclerosis;Autoimmune Diseases;Behavior;Biosensor;cancer therapy;cell behavior;cell motility;Cell Polarity;cell type;Cells;Cellular biology;Compensation;Complex;Decision Making;Enhancers;Feedback;Gene Activation;immune activation;Immunotherapy;Inflammation;Investigation;Light;Logic;Lymphocyte;Molecular;Mouse Embryonic Stem Cells;Movement;Neoplasm Metastasis;neutrophil;optogenetics;Organism;Pathologic Processes;Pattern;Peptides;Process;promoter;Property;Science;Sea;Shapes;Signal Transduction;Specific qualifier value;System;T-Cell Activation;T-Lymphocyte;Testing;tool;transcription factor;Transcriptional Activation;vaccine development;Visualization;Work

PROJECT_TITLE: Cellular Decision Making

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Current standard of care imaging (contrast-enhanced MRI) is limited to detect many neurological and neurodegenerative diseases and spectroscopic MRI has a great potential to supplement routine clinical MRI for clinical conditions including brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating diseases, and infectious brain lesions. This project will improve whole brain coverage and reliability of Spectroscopic MRI, which will be quantitatively assessed in collaboration sites. Successful completion of this study will produce new generation tools needed for broader applications of spectroscopic MRI in patient management with various neurological disorders.

PI_NAMEs: BALLON, DOUGLAS J (contact);DYKE, JONATHAN PAUL

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Amygdaloid structure;Anatomy;Body part;Brain;Brain Hypoxia-Ischemia;Brain Neoplasms;Brain region;Brain Stem;brain volume;Cerebellum;Childhood;Clinical;Collaborations;Communities;contrast enhanced;Contrast Media;Demyelinating Diseases;design;Diffusion Magnetic Resonance Imaging;disability;Disease;Effectiveness;Epilepsy;Evaluation;Freedom;Frontal gyrus;frontal lobe;Functional Magnetic Resonance Imaging;Gadolinium;Generations;Head;Hippocampus;Human;Image;Image Enhancement;imaging modality;Imaging Techniques;Imaging technology;improved;Inferior;Inherited;innovation;Institution;Laws;Lesion;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Measures;Medial;medial temporal lobe;Metabolic;Metabolic Diseases;Methods;millimeter;minimal risk;multidisciplinary;Neonatal;Nervous System Disorder;Neurodegenerative Disorders;novel;operation;Organ;Patients;Pattern;Performance;Persons;Positioning Attribute;Probability;prototype;quantitative imaging;Radiation therapy;Reporting;Reproducibility;Research Personnel;Resolution;RF coil;Role;Sampling;Shapes;Signal Transduction;Site;Slice;spectroscopic imaging;standard of care;Stroke;Structure;Techniques;Technology;Time;tool;Traumatic Brain Injury;treatment planning;Variant;Vendor

PROJECT_TITLE: Unified Shim-RF Coil Technology for Improved Whole-Brain Spectroscopic MRI for Neurological Disorders

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SCRIPPS HEALTH

PHR: 8. Project Narrative (Parent Cyber GEMS study, R01DK124427) Given the known serious consequences of uncontrolled blood sugars during hospitalization, this research proposes an alternative seamlessly integrates continuous glucose monitoring (CGM) in the hospital to test a dynamic and digitized, team-based approach to glucose management in an underserved and understudied, yet high-risk population. The Digital Dashboard is progressive, as it facilitates real-time, remote monitoring of a large volume of patients simultaneously; automatically identifies and prioritizes patients for intervention; and will detect any and all potentially dangerous hypoglycemic episodes in a hospital environment. Finally, our focus on clinical metrics (glucose control, infection) that are in-line with patient priorities and US hospital quality initiatives will increase relevance to healthcare systems and enhance incentive to adopt Cyber GEMS.

PI_NAMEs: FORTMANN, ADELAIDE L;PHILIS-TSIMIKAS, ATHENA  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Administrator;Adopted;Adoption;Algorithms;Ambulatory Monitoring;Blinded;Blood Glucose;blood glucose regulation;Cardiac;cardiometabolism;career development;Caring;Clinical;clinical decision-making;clinical encounter;clinical risk;Clinical Trials;cloud based;Collaborations;Continuous Glucose Monitor;cost effectiveness;Coupled;Dangerousness;dashboard;Data;Death Rate;design;Development;Devices;Diabetes Mellitus;Diagnosis;digital;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;Emergency Situation;Environment;Equity;Ethnic Population;Evaluation;Event;experience;Funding;Glucose;glycemic control;Goals;Health;Health Care Costs;health equity;health literacy;Health system;Healthcare Systems;high risk;high risk population;Hispanic;Home;hospital care;hospital readmission;Hospitalization;hospitalization rates;Hospitals;Hyperglycemia;Hypoglycemia;implementation design;implementation facilitation;implementation facilitators;implementation framework;implementation science;implementation strategy;improved;improved outcome;Incentives;Individual;Infection;infection risk;innovation;Inpatients;insight;Insulin;Intervention;Interview;Knowledge;Latino Population;Learning;Length of Stay;Maps;mathematical ability;Medicine;Mentors;Methods;Minority Groups;monitoring device;mortality;multi-site trial;multidisciplinary;Needs Assessment;Neurologic;Non-Insulin-Dependent Diabetes Mellitus;Nosocomial Infections;novel;parent grant;Parents;Pathway interactions;Patients;Phase;point of care testing;Policies;Policy Maker;Political Factor;poor health outcome;Population;Populations at Risk;Positioning Attribute;prevent;Process;Protocols documentation;provider factors;racial population;Randomized, Controlled Trials;readmission rates;remote monitoring;Research;research to practice;Resources;Specialist;Speed;Standardization;Stratification;Stream;System;Telemetry;Testing;Time;Training;transmission process;treatment as usual;Underserved Population;United States National Institutes of Health;uptake;Visit;wireless transmission;Work

PROJECT_TITLE: Implementation Mapping to develop strategies for improving adoption, implementation and sustainment of CyberGEMS in hospital settings

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: CHANG, POLLY YEE (contact)

PROJECT_TERMS: animal efficacy;Animal Model;Animals;biodosimetry;Clinical;Contracts;Data;Development;drug candidate;efficacy study;Exposure to;Human;Injury;lung injury;manufacture;medical countermeasure;medication safety;Mus;Nuclear;Pharmacology Study;Phase;product development;Radiation exposure;Radiation Injuries;Radiation Toxicity;Radiology Specialty;Recurrence;Rodent;safety study;Sampling;Services;Testing;Toxic effect;Work

PROJECT_TITLE: RADIOLOGICAL/NUCLEAR MEDICAL COUNTERMEASURE (MCM) PRODUCT DEVELOPMENT SUPPORT, ADMINISTRATIVE AND TECHNICAL SUPPORT


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PI_NAMEs: STROUP, ANTOINETTE  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ORG_CITY: SPRINGFIELD

ORG_NAME: ILLINOIS STATE DEPT OF PUBLIC HEALTH

PI_NAMEs: KOCH, LORI  (contact)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Veterans smoke cigarettes at higher rates than the general population, yet most Veterans in VHA care report low motivation to quit. Motivational interviewing (MI) is most commonly used for unmotivated smokers, but data suggests health education (HE) may also help unmotivated smokers. Client language can provide insights into therapeutic techniques associated with behavior change. To elucidate this issue, mixed methods will be used to code and analyze 102 MI and 102 HE sessions from a large community RCT to examine the relationship between key aspects of client language, including statements reflecting plans to change (“change talk”) and evidence of client learning (“learning talk”), and 3- and 6-month treatment outcomes. We will also code and analyze 15 MI and 15 HE sessions from a VHA RCT that included a sample of unmotivated Veteran smokers with mental illness to assess for proportion of CT, LT, and other aspects of client language. Results will be used to combine MI and HE techniques to develop a brief intervention for unmotivated Veteran smokers.

PI_NAMEs: HERBST, ELLEN  (contact)

PROJECT_TERMS: Address;Affect;Behavior;behavior change;brief advice;brief intervention;Caring;Cessation of life;Cigarette;cigarette smoke;Client;Clinic;Clinical;Code;Communities;Community Health Education;Data;Data Set;Disease;Educational Technics;effective intervention;Funding;General Population;Goals;Health;Health education;High Prevalence;improved;improved outcome;innovation;insight;Intervention;intrinsic motivation;Language;Language Development;language outcome;Learning;Link;Low income;Manuals;Measures;Mediating;Mediator;Mental disorders;Mental Health;Methodology;Methods;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;Movement;National Cancer Institute;Outcome;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Population;Practice Guidelines;Prediction of Response to Therapy;primary care practice;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Personnel;response;Safety;Sampling;skills;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking treatment;System;Techniques;Testing;Therapeutic;treatment effect;treatment group;Treatment outcome;trial comparing;United States National Institutes of Health;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Client Language Analysis in Veterans and Non-Veterans with Low Motivation to Quit Smoking: Identifying Mechanisms of Change

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The goal of this study is to develop innovative econometric methods for measuring the value of greater provider options from the perspective of Veterans. The proposed study is timely and policy relevant in light of the Commission on Care’s top long-term recommendation for transforming VHA through the establishment of community care networks for Veterans to access high quality care. Findings from this study will help inform VA’s rapidly evolving role as a payer. Specifically, the development of value measures and the identification of provider attributes that most greatly increase value to Veterans will help VA assess the adequacy of community care networks and select contract providers to most effectively meet Veterans’ health care needs. The strategic selection of high quality provider options available through the Veterans Choice Program and future community care policies is of high interest to key operational partners including the Office of Community Care.

PI_NAMEs: WONG, EDWIN S. (contact)

PROJECT_TERMS: Address;Appointment;Area;Budgets;Businesses;Cardiology;care systems;Caring;Characteristics;Communities;Community Care Networks;Community Healthcare;Community Networks;Contracts;cost;Data;Data Linkages;Degree program;design;Development;Dimensions;Econometric Models;econometrics;economic value;Eligibility Determination;Ensure;Evaluation;Facilities and Administrative Costs;Future;Geographic Locations;Goals;health assessment;health care availability;Health care facility;health care quality;health care service;health economics;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;Heterogeneity;Improve Access;improved;Individual;innovation;interest;Learning;Light;Literature;Location;Logit Models;Marketing;Measurement;Measures;Medical;medical specialties;Methodology;Methods;Modeling;novel;Observational Study;Office Management;opportunity cost;outpatient programs;Outpatients;Parameter Estimation;Patient Preferences;Patient Selection;Patients;Perception;Performance;Policies;Policy Maker;preference;Primary Care;programs;Provider;Quality of Care;Recommendation;Relaxation;Role;Science;simulation;Specific qualifier value;Statutes and Laws;stem;Strategic Planning;Time;tool;Travel;United States;Validation;Veterans;Wait Time;willingness to pay

PROJECT_TITLE: Measuring the Value of Improving Access to Community Care

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The identification of new focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome (NS) genes and further genetic characterization of known FSGS/NS genes will have significant implications for understanding, and ultimately, treating, common forms of kidney disease and progression to kidney failure. In the more immediate future, identification and characterization of FSGS/NS gene defects will have implications for the development of diagnostic tools. !

PI_NAMEs: HILDEBRANDT, FRIEDHELM ;POLLAK, MARTIN R. (contact);SAMPSON, MATTHEW GORDON;SANNA-CHERCHI, SIMONE

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Address;Affect;aggregation database;Alleles;analytical method;Animal Model;Biological Assay;Biological Models;Biology;Cells;Classification;Clinical;cohort;Collection;Communities;Complex;Copy Number Polymorphism;Data;data integration;data resource;Defect;Development;diagnostic accuracy;diagnostic development;diagnostic tool;Disease;disease model;empowerment;Enhancers;Etiology;exome;exome sequencing;Focal and Segmental Glomerulosclerosis;Future;gene discovery;Gene Frequency;gene interaction;Genes;Genetic;genetic disorder diagnosis;genetic profiling;genetic testing;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genomics;Genotype;Goals;Heritability;Human;human model;improved;Individual;induced pluripotent stem cell;Informatics;insertion/deletion mutation;Internet;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Laboratories;Lead;Medical Genetics;Methods;Modeling;Molecular Structure;Mutate;Mutation;Nephrotic Syndrome;novel;nutritional supplementation;Outcome;parallelization;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Penetrance;Phenotype;predicting response;Prevalence;promoter;Reagent;Reporting;Research;Research Personnel;response;Risk;Sample Size;Single Nucleotide Polymorphism;Site;SNP array;Standardization;Steroid therapy;Steroid-resistant idiopathic nephrotic syndrome;System;Technology;Test Result;Testing;Therapeutic;Variant;web portal;Work;Zebrafish

PROJECT_TITLE: Integrating large scale genomics and functional studies to accelerate FSGS/NS discovery


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The NIH has created the Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. Trials will be conducted through the NIH HEAL Pain Management Effectiveness Research Network (HEAL Pain ERN), which will use the infrastructure of the NCATS Trial Innovation Network to provide scientific guidance and coordination of the HEAL Pain ERN Trials. The four resource centers will provide integrated functions for the clinical coordinating resource center, data coordinating resource center, statistics and safety resource center, and recruitment resource center with Johns Hopkins serving as the Statistics and Safety Resource Center.

PI_NAMEs: HANLEY, DANIEL F (contact)

PROGRAM_OFFICER_NAME: VALLEJO, YOLANDA F

PROJECT_TERMS: Administrator;Area;Clinical;Clinical Trials;Collaborations;Data;Data Coordinating Center;design;effectiveness research;Enrollment;experience;Helping to End Addiction Long-term;Infrastructure;innovation;Joints;Lead;Leadership;Multi-Institutional Clinical Trial;multi-site trial;National Center for Advancing Translational Sciences;Opioid;Pain;Pain management;Parents;programs;Protocols documentation;Public Health;recruit;Resources;Safety;Scientist;Specific qualifier value;Speed;statistics;United States National Institutes of Health;Work

PROJECT_TITLE: Johns Hopkins Statistical and Safety Resource Center-HEAL PAIN ERN


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE Gene editing technologies have progressed rapidly in humans and several efforts at clinical translation are ongoing. Recent experiments in translation in reproductive settings have emphasized the need for more values- based and patient-centered governance mechanisms for translation of prenatal gene editing. We propose to conduct empirical and deliberative research to inform a governance structure that is in alignment with patient and clinician priorities.

PI_NAMEs: ALLYSE, MEGAN A. (contact);ISASI, ROSARIO

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Acceleration;Address;advocacy organizations;Affect;aspirate;Assisted Reproductive Technology;Birth;Child;China;Clinical;clinical application;clinical practice;clinical translation;cohort;Communities;Consensus;Country;deliberative democracy;design;Development;Disease;disease-causing mutation;Embryo;Emerging Technologies;Empirical Research;Ethics;Event;Exercise;experimental study;falls;Family;Family member;Future;gene editing technology;Genes;Genetic;Genetic Diseases;Genetic Medicine;Goals;Human;Income;International;Interview;Left;Literature;Methods;novel;Patient advocacy;patient oriented;Patients;Penetrance;permissiveness;Policies;Policy Maker;prenatal;prenatal intervention;Prenatal Structures;pressure;Professional Organizations;Qualitative Research;recruit;Regenerative Medicine;Regulation;reproductive;Reproductive Sciences;Research;Safety;Science Policy;Scientist;Severities;Structure;Support Groups;Technology;translational potential;Translations;United States;Voice

PROJECT_TITLE: PaSAGE: PAtient Supported Approaches to Gene Editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(80)-S]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PI_NAMEs: NOBREGA, MARCELO A.;OBER, CAROLE  (contact);SPERLING, ANNE I.

PROGRAM_OFFICER_NAME: DONG, GANG


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Poor muscle recovery following disuse is frequent amongst older adults leading to low muscle mass, weakness and increased disability. We have proposed to test specific mechanisms of a disrupted macrophage metabolic state during recovery from disuse in aged mice and humans. These findings will produce new knowledge of macrophage metabolism that will aid in the development of therapeutic strategies to promote muscle recovery in aged individuals.

PI_NAMEs: DRUMMOND, MICAH J (contact);O'CONNELL, RYAN M

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Adopted;age related;aged;Aging;aging population;Anti-Inflammatory Agents;Attenuated;Automobile Driving;bone aging;Bone Marrow;Bone Marrow Cell Transplantation;Bone Marrow Cells;Bone Marrow Transplantation;cell age;Cell Physiology;Cells;Characteristics;Chemicals;Citric Acid Cycle;Classification;Coupled;cytokine;Data;Defect;Development;disability;Disuse Atrophy;Enzymes;Event;Exhibits;experimental study;extracellular;fall risk;falls;Fibrosis;Functional disorder;Future;Genetic;Genetic Transcription;Glycolysis;Growth;Growth Factor;Health;Hematopoietic;Hindlimb Suspension;Human;hypoxia inducible factor 1;Immobilization;Immune system;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interruption;Invaded;Knowledge;Limb structure;Literature;Long term disability;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolic Diseases;Metabolism;Methodology;mitochondrial dysfunction;mouse genetics;mouse model;Mus;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;novel;old mice;older adult;Operative Surgical Procedures;Oxidative Phosphorylation;Phenotype;pre-clinical;precursor cell;prevent;programs;Recovery;Recovery Support;reduced muscle mass;Regulation;Resolution;response;restoration;Rodent;Role;sarcopenia;Serum;single-cell RNA sequencing;Skeletal Muscle;stem;stem cell function;Stimulus;Succinates;Testing;Therapeutic;therapeutic development;Transcript;transcription factor;transcriptome;Translating;young adult

PROJECT_TITLE: Regulation of macrophage metabolism in aged muscle during recovery

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PUBLIC HEALTH NARRATIVE Men who have sex with men (MSM), and gender minority individuals who have sex with men, living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER intervention, a virtually delivered 5-session text- enhanced psychobehavioral intervention designed to facilitate viral suppression by addressing internalized stigma and shame as barriers to engagement in HIV care among MSM and gender minority individuals living with HIV and SUDs in two locations with different levels of HIV resources (i.e., the Boston, Massachusetts and Miami, Florida metro areas). MATTER aims to mitigate the negative behavioral consequences of internalized stigma and shame on viral suppression by a) developing behavioral self-care goal setting skills and related self-efficacy, b) increasing metacognitive awareness (i.e., non-judgmental awareness of emotions and cognitions), and c) teaching and reinforcing compassionate self-restructuring (i.e., self- compassion), in addition to providing access to phone-based resource navigation. Scalable interventions such as MATTER are essential to our efforts to end the HIV epidemic in high priority regions.

PI_NAMEs: BATCHELDER, ABIGAIL WINSTON (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Adherence;Adoption;Appointment;Area;arm;Automobile Driving;Awareness;Behavior Therapy;Behavioral;Behavioral Sciences;Boston;Caring;Case Manager;Cognition;Communicable Diseases;Communities;comparison control;cost effectiveness;Data;Drug user;Educational process of instructing;effectiveness evaluation;efficacy evaluation;Emotions;Epidemic;evidence base;experience;Feedback;Florida;follow-up;Future;gender minority;gender minority group;Goals;Health;HIV;housing instability;hybrid type 1 study;hybrid type 2 trial;Hybrids;implementation design;implementation strategy;implementation study;improved;Inequity;informant;innovation;internalized stigma;Intervention;Location;Maintenance;Massachusetts;Mediating;Mediator;men;men who have sex with men;National Institute of Drug Abuse;Outcome;Outcome Measure;Participant;Persons;Positioning Attribute;prevent;Public Health;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Risk;San Francisco;Self Care;Self Efficacy;self-compassion;service engagement;Severities;sex;Shame;Site;skills;social;social stigma;Social Work;substance use;Substance Use Disorder;substance use treatment;Telephone;Text;Text Messaging;therapy design;Time;transmission process;Treatment Efficacy;Viral;Viral Load result;viral rebound;virtual delivery;virtual therapy;Visit

PROJECT_TITLE: Mitigating the Impact of Stigma and Shame as a Barrier to Viral Suppression Among MSM Living with HIV and Substance Use Disorders


PI_NAMEs: FITZGERALD, DANIEL W (contact);RHEE, KYU Y

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS


NIH_SPENDING_CATS: Genetics

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: The goal of this proposal is to understand how cells repair one type of DNA lesion, the double strand break (DSB). DSB repair is essential for a broad range of cellular processes from DNA replication to innate immunity, while dysregulated DNA repair is a hallmark of cancer and other human diseases. Research described in this proposal will increase our understanding of a fundamental biological process and may improve gene editing and chemotherapy.

PI_NAMEs: RICHARDSON, CHRIS  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Aging;Biological Process;Categories;Cell Cycle;Cell Death;cell injury;Cell Physiology;Cells;chemotherapy;Chromatin;Communication;Development;Diagnosis;DNA;DNA Binding;DNA biosynthesis;DNA Double Strand Break;DNA lesion;DNA Repair;Double Strand Break Repair;dynamic system;Event;Excision;falls;Generations;Genes;Genomic Instability;Genomics;Goals;Human;human disease;human DNA;improved;Malignant Neoplasms;Measures;Metabolism;Modeling;Natural Immunity;Outcome;Pathology;Pathway interactions;preservation;Process;protein complex;Proteins;Proteomics;Reagent;Repair Complex;repaired;Research;Resolution;Signal Transduction;Techniques;Therapeutic;Time;tool;Work

PROJECT_TITLE: Defining DNA resection and protein localization changes that occur during DSB repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOLOGY

PHR: Project Narrative  Microsporidia are unicellular,  fungal  parasites with a wide host-range, from insects to humans;  they are emerging pathogens, classified as NIAID Category B opportunistic pathogens, and cause microsporidiosis in immunocompromised patients.  To gain entry into a target cell, microsporidia employ a remarkably unique and specialized harpoon-like invasion machine called the polar tube, which is conserved among microsporidial species. Here we will focus on understanding the mechanism by which microsporidial parasites use this unique organelle to initiate infection, which may provide broader insights into infection mechanisms used by other eukaryotic parasites.

PI_NAMEs: BHABHA, GIRA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Animals;Architecture;Biochemical;Biochemistry;Biological Assay;Biology;Biophysics;Bombyx;burden of illness;Categories;Cells;Cellular biology;Cilia;Classification;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Data;Disease;electron tomography;emerging pathogen;Encephalitozoon cuniculi;Encephalitozoon hellem;Environment;experimental study;Face;Farm;Fishes;Fluorescent Dyes;Freezing;genetic manipulation;Growth;Human;human pathogen;Image;Immunocompromised Host;In Situ;In Vitro;in vivo;Individual;Infection;Insecta;insight;Invaded;Ions;Light;light microscopy;lightspeed;Mass Spectrum Analysis;Microscopy;Microsporidia;Microsporidiosis;Microtubules;Modernization;Molecular;Molecular Conformation;mortality;Movement;Names;National Institute of Allergy and Infectious Disease;opportunistic pathogen;Optics;organ transplant recipient;Organelles;Parasites;particle;pathogen;Patients;Process;protein complex;protein protein interaction;protein purification;Protein Subunits;Proteins;Proteome;reconstruction;Reproduction spores;Resolution;Sampling;Scanning Electron Microscopy;Sequence Homology;Side;Speed;structural biology;Structure;Techniques;Thinness;Tube;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural basis of the polar tube invasion machinery from microsporidia parasites

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANAHEIM

ORG_NAME: LEBRUN LABS, LLC

PHR: Narrative Currently, there are no accurate nonanimal tests to identify consumer products and chemicals that require labeling to advise users to wear protective eyewear and avoid eye contact due to the threat of serious eye damage. The purpose of this application is to further develop and commercialize a new nonanimal test — the in vitro depth of injury eye irritation test (IVD EIT) — to identify this class of ocular irritants and thereby allow for adequate labeling that will advise and inform users about product safety as well as comply with new laws preventing or limiting the use of animals that have been historically used for this type of routine safety testing. 1

PI_NAMEs: LEBRUN, STEWART  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;Animal Sources;Animal Testing;Animals;Area;Benchmarking;Biological Assay;Biological Markers;California;Categories;Cell Death;Cell Survival;Chemicals;Classification;Code;commercialization;consumer product;Cornea;Corrosives;Dangerousness;Data;Detection;Development;Diagnostic Reagent Kits;Dose;Ensure;European Union;Eye;Eye Injuries;Feasibility Studies;Felis catus;Food;Future;Generations;Goals;Grant;Hazardous Chemicals;Hour;improved;In Vitro;in vitro testing;in vivo;Incubated;Industry;Irritants;irritation;Label;Laws;Liquid substance;manufacture;Manufacturer;Measures;Methods;Oryctolagus cuniculus;Performance;Phase;phase 1 study;predictive modeling;Preparation;prevent;Procedures;Process;Product Labeling;Protocols documentation;Refrigeration;Research;retinal toxicity;Safety;safety testing;Sampling;Sensitivity and Specificity;Services;Small Business Innovation Research Grant;Solid;Specificity;Standardization;Statutes and Laws;success;Surface;surfactant;Testing;timeline;tool;United States;validation studies

PROJECT_TITLE: IVD EIT a Nonanimal Kit and Service for the Detection of Ocular Irritants: Phase II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Cognitive deficits that occur with aging are a pervasive concern to older individuals and a growing public health issue and maintaining or improving cognition in older adults could have an important effect at the population level, potentially delaying the onset of Alzheimer’s disease and other dementias in millions of older adults. The goals of the proposed research are to first determine the minimal and/or optimal dose of a meditation-inspired digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovascular risk, and race/ethnicity). This knowledge gained from his high-impact study with transform the field of cognitive interventions, paving the way for a precision medicine model for cognitive enhancing interventions that improve quality of life for older adults and individuals with cognitive deficits at risk of developing dementia.

PI_NAMEs: GAZZALEY, ADAM H;ZIEGLER, DAVID A (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adolescent;Advanced Development;age related;Age Years;Aging;aging biomarker;aging population;Alzheimer's Disease;Atrophic;Attention;attentional control;Behavior;cardiovascular risk factor;Clinical;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive enhancement;Cognitive remediation;cohort;Country;Data;Dementia;design;digital;digital intervention;distraction;Dose;Ethnic Origin;Exhibits;experience;Experimental Designs;Explosion;follow up assessment;follow-up;functional decline;functional outcomes;General Population;Genetic;Goals;handheld mobile device;hazard;Human Characteristics;Impaired cognition;improved;indexing;Individual;individual variation;Intervention;Intervention Trial;Knowledge;Lead;Meditation;Memory impairment;Mental Health;Methodology;mild cognitive impairment;Modeling;Moods;neural;Neurodegenerative Disorders;neuropathology;novel;older adult;Older Population;Participant;Patients;Performance;Personal Satisfaction;pharmacologic;Physiological;Population;Populations at Risk;pre-clinical;precision medicine;prevent;Preventive therapy;primary outcome;Psychiatry;Public Health;Quality of life;Race;Randomized, Controlled Trials;Reaction Time;recruit;Regulation;Research;response;Risk;Sample Size;Sampling;social;Societies;Source;Stress;stress reactivity;stress reduction;Subgroup;success;sustained attention;Symptoms;telomere;treatment effect;treatment program;treatment response;vigilance;white matter;young adult

PROJECT_TITLE: Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adults


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Use of tobacco products is a strong predictor of nonmedical use of prescribed opiates, development of opiate dependence, and susceptibility to accidental opiate overdose. Nicotine use results in insular cortex dysfunction which is further associated with development of substance use disorders. Elucidation of the mechanisms through which nicotine, acting within the insular cortex, may enhance opiate addiction liability is critical for development of treatment strategies aimed at the large proportion of nicotine and opiate polysubstance users currently involved in opiate treatment programs.

PI_NAMEs: LONEY, GREGORY CARL (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Accidents;addiction liability;Anterior;behavior measurement;behavioral pharmacology;Chemosensitization;comorbidity;conditioned place preference;Data;Development;Dose;drug of abuse;Electrophysiology (science);experimental study;Functional disorder;Future;Genetic;genetic manipulation;Goals;in vivo;Maintenance;Morphine;neural circuit;Nicotine;nicotine abuse;nicotine use;nonmedical use;Opiate Addiction;Opioid;opioid abuse;opioid misuse;opioid overdose;opioid treatment program;Output;Patients;polysubstance use;Predisposition;prescription opioid;Principal Investigator;Property;Psychophysics;Public Health;Research;Role;Site;Stimulus;stimulus processing;Substance Use Disorder;Synapses;Taste Perception;Technical Expertise;therapy development;tobacco smokers;Tobacco use;tobacco user;Training;treatment program;treatment strategy

PROJECT_TITLE: Nicotinic and Insular Cortical Mechanisms Contributing to Opiate Misuse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Endocrine Disruptors;Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative Pregnant women and children are exposed to a mixture of chemicals. We will investigate the impact of prenatal and postnatal exposures to chemical mixtures on child cognition, attention/executive function, externalizing and internalizing behaviors, and brain imaging. We will use two well-characterized birth cohort studies in the U.S. and Canada to identify the impact of a single chemical, interactions between chemicals, and joint effect of multiple chemicals.

PI_NAMEs: CHEN, AIMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 12 year old;adverse birth outcomes;Affect;Age;Air;American;Anatomy;Anxiety;Arsenic;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavioral outcome;Biological Markers;Birth;bisphenol A;Brain;Brain imaging;Cadmium;Calcium Signaling;Canada;Central Nervous System;chemical association;Chemicals;Child;Child Development;Chlorinated Hydrocarbons;Chlorpyrifos;Cognition;cognitive ability;cognitive function;cohort;Cohort Studies;Conduct Disorder;Data;design;Development;developmental neurotoxicity;dichlorodiphenyltrichloroethane;Diet;Dust;Elasticity;Endocrine Disruptors;Environment;environmental chemical;Environmental Epidemiology;Environmental Health;Environmental Pollutants;epidemiology study;Epigenetic Process;executive function;Exposure to;Fetal Development;Flame Retardants;Fluorides;follow-up;Health;Heavy Metals;Height;Human Milk;Individual;Infant;Investigation;Joints;Lead;Learning;Learning Disabilities;Least-Squares Analysis;Life;Literature;Manganese;Measures;Mediation;Mental Depression;Mercury;Metals;Methods;Methylmercury Compounds;migration;myelination;National Health and Nutrition Examination Survey;neural network;neurobehavior;neurobehavioral;neurochemistry;neurodevelopment;neuroimaging;Neurons;Neurosecretory Systems;Neurotoxins;neurotransmitter release;neurotransmitter uptake;Neurotransmitters;organochlorine pesticide;Organophosphates;Outcome;Oxidative Stress;Parabens;persistent organic pollutants;Pesticides;Phenols;phthalates;Placenta;Policy Making;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Polychlorinated Biphenyls;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Problem behavior;Proliferating;Prospective cohort;pyrethroid;Research;sex;Statistical Methods;Structure;Synapses;Testing;Tetrachloroethylene;Tobacco smoke;Toluene;Toxicant exposure;Triclosan;Water;white matter

PROJECT_TITLE: Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]