NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because African Americans have more than two times the risk of Alzheimer's disease (AD), the most expensive medical condition in the US. The proposed research study will test specific hypotheses about the interplay of genetic variations and potentially modifiable health/lifestyle factors (i.e., aerobic fitness and sleep quality) to influence cognitive decline and AD risk in older African Americans, while exploring the role of sex differences and socio-environmental factors. Insights into these novel interactions could lead to “Precision Lifestyle Medicine” specific to African Americans, in which particular lifestyle changes (e.g., improving sleep or getting more aerobic exercise) could be prescribed for those with specific genetic variations while keeping in mind one's socio-environmental context that influences modifiable health/lifestyle behaviors.

PI_NAMEs: GLUCK, MARK A (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Address;Aerobic Exercise;African American population;Age;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;apolipoprotein E-4;Area;Attention;Award;Behavior;behavior influence;Biological Markers;blood-based biomarker;brain health;caucasian American;Censuses;Cessation of life;Church;Classification;Clinic;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive performance;cohort;Communities;community engagement;community partners;community research;Complex;COVID-19;COVID-19 mortality;Data;deprivation;Enrollment;Environmental Risk Factor;Exercise;Family;fitness;flexibility;follow-up;foot;Functional Magnetic Resonance Imaging;Future;Genetic;genetic risk factor;Genetic Variation;Glial Fibrillary Acidic Protein;Goals;Grant;Health;health assessment;Health behavior;Health Disparities Research;health disparity;high risk;Impaired cognition;improvement on sleep;indexing;Individual;innovation;insight;Knowledge;Learning;life span;Life Style;lifestyle factors;Longitudinal Studies;Magnetic Resonance Imaging;Measures;medial temporal lobe;Medical;Medicine;Memory;Methodological Studies;mild cognitive impairment;neighborhood disadvantage;neural;neuromechanism;neuropathology;Neurophysiology - biologic function;neuroprotection;Neuropsychology;novel;older adult;Outcome;pandemic disease;Paper;Participant;Pathology;Performance;Persons;poor sleep;Predictive Value;Prevalence;primary outcome;prodromal Alzheimer's disease;Productivity;programs;Protocols documentation;Public Health;Public Housing;Publications;Radial;recruit;Research;Research Infrastructure;research study;Risk;Risk Factors;risk variant;Role;secondary outcome;Sex Differences;Site;sleep quality;Social Environment;social health determinants;socioenvironmental factor;Stimulus;success;tau-1;Testing;tool;Variant

PROJECT_TITLE: Risk Factors for Future Cognitive Decline and Alzheimers Disease in Older African Americans

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Clonal hematopoiesis (CH) increases the risk of acute myeloid leukemia and mortality of cardiovascular disease and non-hematological cancers, and is associated with increased inflammation, which confers a selective advantage to CH-mutant hematopoietic stem and progenitor cells (HSPCs). My predoctoral research will identify inflammatory gene targets essential to CH-mutant HSPCs but not wild-type counterparts to restore oligoclonal hematopoiesis while avoiding disrupting global immune responses. In addition, my postdoctoral direction will reveal the unique transcriptional and epigenetic circuitries that age-related inflammation exploits in CH-mutant HSPCs to promote their expansion, critical knowledge to developing precision medicine therapies to prevent CH progression to leukemia.

PI_NAMEs: FERNANDEZ MAESTRE, INES  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;adverse outcome;Age;age related;Aging;aging related;Alleles;anti-cancer research;Anti-Inflammatory Agents;Attenuated;Automobile Driving;Bone Marrow;cancer therapy;Candidate Disease Gene;Cardiovascular Diseases;career development;cell type;Cells;Chemicals;ChIP-seq;Chronic;Clinical;Clonal Expansion;Coculture Techniques;cohort;Complex;Credentialing;CRISPR screen;Custom;cytokine;Dependence;design;Development;Development Plans;Doctor of Philosophy;Elderly;Endothelial Cells;Environment;Epigenetic Process;epigenomics;Feedback;fitness;Foundations;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Genotype;Goals;graduate school;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;High Prevalence;Human;Immune response;in vivo engraftment;Incidence;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;Institution;Interleukin-1;Interleukin-6;Knock-out;Knowledge;Laboratories;leukemia;leukemic transformation;Libraries;Ligands;Link;Malignant - descriptor;Mediator;Memorial Sloan-Kettering Cancer Center;mortality;mouse model;multiple omics;Mus;mutant;Mutation;Myeloid Cells;new therapeutic target;Non-Hematologic Malignancy;novel;novel therapeutics;old mice;Pathology;Pathway interactions;Patients;Postdoctoral Fellow;pre-doctoral;precision medicine;pressure;prevent;pro-aging;rational design;Research;research and development;Resources;Risk;Role;Sampling;self-renewal;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Solid Neoplasm;Somatic Mutation;stem cell expansion;System;Testing;therapeutic target;therapeutically effective;TNF gene;Training;transcriptomics;Work

PROJECT_TITLE: Identifying Inflammatory Mediators of Clonal Hematopoiesis


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: CARMICHAEL, SUZAN L (contact)

PROJECT_TERMS: Address;Affect;Anemia;antenatal;Area;Attention;Birth;Cesarean section;Clinical;clinical care;Clinical Medicine;clinical training;Communication;Communities;community building;community engaged research;community engagement;community partners;community partnership;Competence;Complex;design;Discipline;Discipline of obstetrics;Emergency Situation;Ensure;Environment;Epidemiology;Equity;experience;Foundations;Future;Goals;Hemorrhage;high risk;implementation science;improved;Individual;Inequity;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Knowledge;Lead;Learning;learning engagement;Logistics;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Mental Health;Mentors;multidisciplinary;neglect;Patients;Performance;Persons;Postpartum Hemorrhage;Postpartum Period;prevent;Prevention;prevention practice;Process;programs;Psychology;Qualifying;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Safety;Science;severe maternal morbidity;simulation;skills;social health determinants;Training;Training Activity;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: PRIHSM Training Component

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Pendrin (SLC26A4) is an anion transporter that is expressed in epithelial cells, e.g., in the inner ear, thyroid, kidney, and lung where it plays a central role in ion homeostasis, and it is the molecular target of the non-steroidal anti-inflammatory drug niflumic acid. Mutations in the Slc26a4 gene cause Pendred Syndrome and Enlarged Vestibular Aqueduct Syndrome (EVAS), both of which are genetic disorders characterized by early hearing loss in children and account for 5-10% of hereditary hearing loss. The physiology and pathophysiology of pendrin is poorly understood, and this project, by using structural studies in conjunction with advanced transport and binding studies, seeks to elucidate the mechanism and pharmacology of pendrin at atomic level to aid in the development of efficacious therapies.

PI_NAMEs: QUICK, MATTHIAS  (contact);ZHOU, MING

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;airway hyperresponsiveness;Anions;antagonist;Anti-Inflammatory Agents;antiport;Asthma;Bicarbonates;Binding;Binding Sites;Biological Assay;causal variant;Cell membrane;Cell Volumes;Chemical Structure;Child;childhood hearing loss;Chloride Ion;Cholesterol;Clinical;Cochlea;Complex;Cryoelectron Microscopy;Dedications;Development;Disease;Drug Targeting;early childhood;efficacious treatment;Electrons;Environment;Epithelial Cells;Epithelium;experimental study;Foundations;Functional disorder;Genes;Genetic Diseases;Goals;Health;hereditary hearing loss;Homeostasis;Homologous Gene;Human;Hydroxide Ion;Hypertension;improved;inhibitor;insight;Iodides;Ion Exchange;Ion Transport;Ions;Kidney;Knowledge;Labyrinth;Lipids;Lung;Membrane Lipids;Molecular Target;Motivation;Mutation;new therapeutic target;Niflumic Acid;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Pendred Syndrome;pH Homeostasis;Pharmaceutical Preparations;Pharmacology;Physiological;Physiology;Play;protein expression;protein purification;Proteins;Reaction;reconstitution;Regulation;Reporting;Role;side effect;Sigma Factor;small molecule;small molecule inhibitor;Solid;stoichiometry;Structure;sulfate transporter;Syndrome;System;Thyroid Gland;Time;Tissues;Transmembrane Domain;Transport Process;Variant;Vestibular Aqueduct;Work

PROJECT_TITLE: Structure and mechanism of pendrin and the mutations that cause Pendred's Syndrome

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: PROJECT NARRATIVE Neurons in the human brain can be categorized into thousands of distinct “cell types,” each with unique properties, functions, and contributions to disease states. A comprehensive understanding of different cell types requires observing their electrical activity in living brains—however, the current technologies for doing this are quite limiting. We propose to develop a new device that makes it much easier for researchers to record from, identify, and stimulate different cell types throughout the brain, and which is also compact and affordable.

PI_NAMEs: SIEGLE, JOSHUA H;SVOBODA, KAREL  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Action Potentials;Adoption;advanced system;Anatomy;Area;Behavior;Brain;brain cell;BRAIN initiative;Brain region;Categories;cell type;Chronic;Classification;Cognition;Collaborations;Color;Communities;Complex;Computer software;Corpus striatum structure;cost;Data;data acquisition;density;design;Development;Devices;Disease;efficacy validation;Electrodes;Electrophysiology (science);Elements;Enterobacteria phage P1 Cre recombinase;entorhinal cortex;experimental study;extracellular;fabrication;flexibility;FLP recombinase;genetic manipulation;Goals;Heating;Human;Implant;implantable device;improved;in vivo;Individual;information processing;Laboratories;Lead;Light;light gated;Link;manufacture;manufacturing cost;manufacturing process;Measures;Methods;millisecond;miniaturize;Molecular;Monitor;Morphology;Mus;nanoelectronics;neural;neural circuit;Neurons;Neurophysiology - biologic function;Neurosciences;Opsin;Optics;optogenetics;Pattern;Perception;Phase;Play;Population;Positioning Attribute;Process;Property;prototype;Reagent;redshift;Reporter;research and development;Research Personnel;Role;Signal Transduction;Silicon;single cell genomics;Site;Source;stability testing;System;Taxonomy;Technology;temporal measurement;Testing;Time;Tissues;tool;Training;transgene expression;Transgenic Mice;Transgenic Organisms;Ventral Tegmental Area;Viral Genes;Visual Cortex;Visualization;Work

PROJECT_TITLE: Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) are the most common causes of dementia (cognition decline that leads to a loss of independent function) among adults. Current pharmacologic treatments have limited benefits, and non-pharmacologic approaches, such as music-based interventions, have potential to improve health and well-being. We propose to create a Research Network to accelerative mechanistic studies of music-based interventions in the context of AD/ADRD.

PI_NAMEs: JOHNSON, JULENE K (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Adult;Affect;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;American;Anxiety;Arizona;Behavior;behavior change;Behavioral;Brain;Brain imaging;brain research;California;Caregiver Burden;Caring;Catalogs;Code;Cognition;cognitive neuroscience;cohort;Collaborations;Complex;cost;cost effective;Dementia;Diagnosis;disability;Educational workshop;Effectiveness;Engineering;Ethnic Origin;Evaluation;experience;FDA approved;Fostering;Frontotemporal Dementia;Funding;Geriatrics;Goals;Growth;Health;health disparity;Hispanic-serving Institution;human old age (65+);Imaging technology;improved;Institution;Interdisciplinary Study;Intervention;Lewy Body Dementia;Measures;Mental Depression;Mentors;Methodology;Methods;mobile computing;Modeling;Moods;Morbidity - disease rate;mortality;multidisciplinary;Music;Music Therapy;neural;Neurodegenerative Disorders;neuroregulation;new technology;Nonpharmacologic Therapy;novel;older adult;Outcome;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;Prevalence;prevent;programs;Publications;Quality of life;racial diversity;Randomized;Research;Research Personnel;Resources;Sampling;San Francisco;Science;Scientific Advances and Accomplishments;statistics;Symptoms;Technology;Testing;Time;Training;United States National Institutes of Health;Universities;webinar;Well in self;working group

PROJECT_TITLE: Research Network to Accelerate Mechanistic Studies of Music for Dementia (RN-MusD)


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative  The trends in opioid drug abuse and overdose deaths has continued relatively unabated. Buprenorphine has shown great promise in assisting people recovering from opioid dependence, but current treatment induction, retention, and regimens remain problematic for many. The goal of this project is to optimize and advance into clinical trials an injectable ≥3-month buprenorphine compressed single-rod formulation.

PI_NAMEs: OTTE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: Academia;Acids;acute care;Adherence;Aftercare;Agonist;American;antagonist;base;Behavior Therapy;biocompatible polymer;biodegradable polymer;Buprenorphine;buprenorphine treatment;candidate selection;canine model;Characteristics;Clinic;Clinical;Clinical Research;Clinical Trials;combat;Communities;Computing Methodologies;controlled release;Counseling;COVID-19 pandemic;Data;design;Development;Development Plans;Dimensions;Dose;Dropout;Drug Controls;Drug Delivery Systems;Drug Industry;Drug Kinetics;drug release kinetics;Drug Utilization;Dryness;Equilibrium;Event;Excipients;Excision;expectation;experience;Family;Fiber;Formulation;Foundations;Goals;Government;healthy volunteer;Implant;Improve Access;improved;In Vitro;in vitro Model;in vivo;Individual;Industry;Injectable;innovation;kappa opioid receptors;Kinetics;Length;manufacture;Marketing;medication-assisted treatment;meetings;Methadone;Modality;Molecular;mu opioid receptors;Naltrexone;non-compliance;novel;Opiate Addiction;Opioid;opioid abuse;Opioid Antagonist;opioid epidemic;Opioid replacement therapy;opioid use disorder;Outcome;Overdose;overdose death;pandemic disease;particle;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Physicians;Polymers;Pre-Clinical Model;prevent;Process;product development;programs;Property;Regimen;Research;research and development;Research Project Grants;retention rate;Rod;Rodent Model;small molecule;sound;Substance Use Disorder;substance use treatment;System;Technology;Therapeutic;therapy duration;tool;Toxic effect;treatment duration;trend;United States Food and Drug Administration;Workplace

PROJECT_TITLE: Long acting biodegradable buprenorphine depots

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We have developed a large functional screen to dissect the contributions of inflammatory bowel disease (IBD)- associated polymorphisms to the variation between individuals in pattern recognition receptor (PRR)-induced cytokines; this provides a uniquely powerful means of determining the functional consequences of a number of IBD-associated genetic loci. We will utilize this screen, along with implementing a screen that now evaluates the balance between critical cytokine and antimicrobial pathways, to identify those IBD-associated polymorphisms contributing to PRR-initiated outcomes and then dissect the mechanisms wherein both the genes and the specific polymorphisms within the genes modulate these outcomes. We anticipate that studies focused on disease-associated polymorphisms that modulate the balance between cytokines and antimicrobial pathways, the dysregulation of which is a major feature of IBD pathogenesis, will ultimately result in improved disease classification and in prioritization of new therapeutic targets for IBD.

PI_NAMEs: ABRAHAM, CLARA  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Acetylmuramyl-Alanyl-Isoglutamine;antimicrobial;autocrine;Autoimmunity;Automobile Driving;Candidate Disease Gene;Cells;Classification;cohort;Colony-forming units;cytokine;density;Deubiquitinating Enzyme;Development;Disease;disease classification;Disease susceptibility;Endoplasmic Reticulum;Equilibrium;functional outcomes;Future;gain of function;gene function;Genes;Genetic;Genetic Diseases;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Variation;genomic locus;Human;human disease;Human Genetics;Immune;Immune response;improved;in vivo;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;insight;inter-individual variation;Intestinal Diseases;Intestines;JAK2 gene;knock-down;Macrophage;MAP3K8 gene;Maps;Mediating;Microbe;microbial;microbial disease;microbial products;Molecular;monocyte;new therapeutic target;novel;novel therapeutics;Outcome;paracrine;Pathogenesis;Pathway interactions;Patients;Pattern Recognition;Pattern recognition receptor;Predisposition;Proteins;Quantitative Trait Loci;Reactive Nitrogen Species;Reactive Oxygen Species;receptor;Receptor Activation;response;risk variant;Role;Single Nucleotide Polymorphism;STAT1 gene;STAT3 gene;STAT4 gene;Stat5 protein;System;Testing;therapeutic target;Tissues;TNFSF15 gene;Toll-like receptors;ubiquitin isopeptidase;Ulcerative Colitis;Variant

PROJECT_TITLE: Functional outcomes of inflammatory bowel disease associated variants

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Rotavirus and enterotoxigenic Escherichia coli are among the leading causes of severe gastroenteritis, diarrhea, and death in infants and young children. We propose to take advantage of the newly developed rotavirus reverse genetics system to generate a rotavirus-based dual vaccine candidate that encode enterotoxigenic Escherichia coli antigens. Our results will establish the translational utility of rotavirus-based enteric viral vectors and facilitate the rational design of novel mucosal vaccine platforms, thereby treating enteric infections and reducing the overall morbidity and mortality.

PI_NAMEs: DING, SIYUAN  (contact);FLECKENSTEIN, JAMES MICHAEL

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Affect;Age;Animal Model;Anti-viral Agents;Antibodies;Antibody Response;Antigens;Astrovirus;Atrophic;Attenuated;Automobile Driving;Biological Assay;Biology;Body Weight decreased;Body Weights and Measures;Cessation of life;Child;co-infection;cognitive development;Colony-Forming Units Assay;Country;Cryptosporidium;Cyclic AMP;Cyclic GMP;Data;design;Development;Diarrhea;diarrheal disease;Disease;Double-Stranded RNA;efficacy evaluation;Enteral;enteric infection;enteric pathogen;enterotoxigenic Escherichia coli;Enterotoxins;Enzyme-Linked Immunosorbent Assay;Equilibrium;Escherichia coli Infections;Etiology;Future;Gastroenteritis;Genetic Engineering;Genome;Goals;Growth;Harvest;Heterophile Antigens;Human;Immune response;Immunity;Immunize;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;improved;Infant;Infant Mortality;Infection;innovation;Intestines;Laboratories;Licensing;Malaria;Measles;Measures;Medical;Methods;Monitor;Morbidity - disease rate;mortality;mouse model;mucosal vaccine;Mucous Membrane;Mus;mutant;nanoluciferase;Neonatal;neonatal mice;neutralizing antibody;Norovirus;novel;Oral;Organoids;Outcome;pathogen;Pathogenesis;Plaque Assay;prevent;protective efficacy;pup;rational design;Recombinants;Reporter;Resolution;response;reverse genetics;RNA vaccine;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Rotavirus VP6 protein;Series;Serum;Shigella;Small Intestines;Specimen;suckling;System;Testing;Therapeutic Intervention;tissue culture;Tissues;Toxic effect;Toxin;Toxoids;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine platform;Vaccines;vector;vector induced;vector vaccine;Vertebral column;Villus;Viral;Viral Vector;Virulence;Virulent;Virus;Virus Replication;Viviparous-1 protein

PROJECT_TITLE: Development of rotavirus-based enterotoxigenic Escherichia coli dual vaccines

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE We propose to recruit a diverse cohort of pregnant people and their partners from a large hospital system in Denver, Colorado, and to implement the ECHO Cohort Protocol to collect high-quality longitudinal data on parents and offspring. Our research will leverage the exceptional data resources generated by the ECHO Program to inform policies, practices, and programs aimed at reducing environmental chemical exposures in early life, and promoting data-driven interventions to improve the health and well-being of children.

PI_NAMEs: DABELEA, DANA  (contact);MOORE, BRIANNA F;STARLING, ANNE

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: 3-Dimensional;Address;Adverse effects;Affect;Air Pollution;Biogenesis;Biological;Birth;Cannabinoids;cardiometabolism;Chemical Exposure;Chemicals;Child;Child Health;Child Welfare;Childhood;cohort;Colorado;Conceptions;Data;Data Collection;Data Element;data resource;design;Development;Diet;Disease;early life exposure;Endocrine Disruptors;Enrollment;Ensure;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;environmental tobacco smoke exposure;epigenetic marker;Epigenetic Process;Ethnic Origin;Exclusive Breastfeeding;experience;Exposure to;Family;Federally Qualified Health Center;Goals;Green space;Growth;Health;Hospitals;Human Milk;improved;Individual;Infant;International;Intervention;Joints;Lactation;Lead;Life;Life Style;lifestyle factors;Link;marijuana use;Measures;Mediating;molecular marker;neurodevelopment;novel;Obesity;obesity in children;obesity risk;offspring;Outcome;Parents;Participant;Pathway interactions;Patients;Pattern;Persons;Pilot Projects;Policies;Policy Maker;Population;Population Heterogeneity;Positioning Attribute;postnatal;postnatal period;Predisposition;Pregnancy;pregnant;prenatal;Prenatal care;prenatal exposure;Prenatal Nutrition;prevent;Prevention;Probability;Procedures;programs;protective factors;Protocols documentation;Race;recruit;Research;Research Personnel;Resources;response;retention rate;Risk;risk minimization;Sample Size;Science;Site;social health determinants;socioeconomics;sperm cell;System;Toddler;Urban Hospitals

PROJECT_TITLE: Early Life Determinants of Child Health: A New Denver-Based Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Kyrgyzstan is part of the world’s most rapidly expanding HIV epidemic in the Eastern Europe and Central Asia region, where HIV is predominantly concentrated among persons who inject drugs (PWID). Our previous work documented that while awareness of PrEP is increasing among PWID, uptake is low, and intersecting stigmas related to HIV, drug use, and drug treatment (i.e. methadone) uniquely amplify HIV risk in this population and impede the use of evidence-based HIV services such as HIV testing, syringe service programs, methadone maintenance therapy. Evidence speaking to the potential for multilevel stigma reduction strategies to unlock the prevention power of these services for PWID in Kyrgyzstan and the broader EECA region is needed.

PI_NAMEs: SMITH, LARAMIE RAE (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Abstinence;Acceleration;Address;Adopted;antiretroviral therapy;Automobile Driving;Awareness;Behavior;Capital;Caring;Central Asia;Cities;Client;Clinic;Communities;control trial;cost;Data;design;Drug Addiction;drug maintenance;Drug usage;Eastern Europe;Effectiveness;Effectiveness of Interventions;Epidemic;Europe;evidence base;experience;follow-up;Future;Geography;Goals;Health;Health care facility;Health Personnel;Hearing;high risk;HIV;HIV diagnosis;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;Hybrids;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;Incidence;Injecting drug user;injection drug use;Injections;innovation;International;Intervention;Intervention Studies;Kyrgyzstan;Left;Maintenance;Measures;Methadone;methadone treatment;Methods;Modeling;National Institute of Drug Abuse;Needle-Exchange Programs;opioid use disorder;Outcome;Persons;Pharmacotherapy;Policies;Population;post intervention;Practical Robust Implementation and Sustainability Model;pre-exposure prophylaxis;prevent;Prevention;Randomized;Reporting;Research Design;research to practice;response;Risk;Risk Behaviors;Risk Reduction;scale up;service uptake;Services;social stigma;standard of care;Stigmatization;Syringes;Technology;Testing;Time;transmission process;treatment arm;treatment as prevention;treatment services;uptake;Waiting Lists;Work

PROJECT_TITLE: Reducing HIV-related Intersectional Stigma and Risk among People who Inject Drugs in a High Risk International Setting

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

PHR: Project Narrative This project is a study of remission from alcohol use disorders (AUDs), also known as recovery, and how remission in parents influences the home environment and alcohol use of adolescent and adult children. We seek to understand whether parental remission can reduce the likelihood of alcohol problems in their children, despite genetic risk for alcohol problems, and thereby reduce the transmission of AUDs from one generation to the next.

PI_NAMEs: MCCUTCHEON, VIVIA V (contact);SALVATORE, JESSICA E

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: abuse neglect;adolescent offspring;Adult;Adult Children;Affect;Age;age difference;Alcohol abuse;alcohol consequences;Alcohol consumption;Alcohol Phenotype;alcohol risk;alcohol use disorder;Alcohols;Behavioral;behavioral phenotyping;Biological;Birth;Black race;Child;Child Abuse;child bearing;Child Rearing;chronic alcohol ingestion;Clinical;cognitive function;cohort;cost;Data;density;design;Disease;Disease remission;Divorce;Economic Burden;Economics;Education;Emotional;Employment;Environment;Environmental Exposure;Environmental Risk Factor;experience;externalizing behavior;Family;Fathers;General Population;Generations;Genes;Genetic;Genetic Risk;genetics of alcoholism;genome wide association study;Genotype;Goals;Health Services Accessibility;high risk;Home environment;Household;improved;Income;Individual;Inherited;innovation;intergenerational;Literature;Marital Status;Marriage;Measures;men;Mental Depression;Mental disorders;Methods;Molecular Genetics;Mothers;Movement;Nuclear Family;offspring;Onset of illness;Outcome;parental influence;Parents;Participant;Patients;pediatric trauma;person centered;Phenotype;Poverty;Prevention;Probability;protective effect;Recovery;recruit;Relapse;Research;resilience;Risk;Role;Running;Sampling;Science;segregation;sex;Siblings;Societies;Substance Use Disorder;Survival Analysis;symptomatology;Symptoms;Testing;transmission process;traumatic event;underage drinking;Variant;Woman;young adult

PROJECT_TITLE: The role of remission in the intergenerational transmission of alcohol use disorder: Course, context, and offspring outcomes

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: In this project, we seek to continue follow-up of children drawn from families who have an older child with autism through the critical and under-studied period of adolescence and early adulthood in the Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) project. Our project will fill needed gaps in autism spectrum disorder (ASD) research, while contributing to the efforts of the ECHO program, addressing joint effects of environmental exposures on neurodevelopmental outcomes, evaluating health outcome of adolescents with and without neurodevelopment conditions while also examining additional ways to measure neurodevelopmental outcomes, and presenting a unique resource of longitudinal data in this population by implementing the ECHO protocol.

PI_NAMEs: LYALL, KRISTEN  (contact);VOLK, HEATHER E

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Abbreviations;Address;Adolescence;Adolescent;adolescent health outcomes;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;age group;Air Pollutants;Air Pollution;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic;autistic children;Automobile Driving;Behavioral;Child;Child Health;Childhood;cohort;Cohort Studies;Collection;Communities;Cross-Sectional Studies;Data;Data Collection;Diagnosis;Diagnostic;Diet;dietary;Dietary Factors;dimensional analysis;early childhood;early life exposure;emerging adult;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;epidemiology study;Etiology;Exposure to;Family;Fatty Acids;Fishes;Folic Acid;follow-up;General Population;Genetic;Genetic Variation;Goals;Health;health assessment;healthcare burden;Healthy Eating;Heritability;Incentives;indexing;individuals with autism spectrum disorder;Intake;Intellectual functioning disability;Joints;Language;Life;life span;Longitudinal Studies;Measurement;Measures;Mental Health;Methods;Modification;Names;Neighborhoods;neurodevelopment;Neurodevelopmental Disorder;Nutrient;Outcome;outcome prediction;Participant;Pattern;Personal Satisfaction;Phase;Phenotype;physical conditioning;Play;polygenic risk score;Population;prenatal;prenatal exposure;Prevalence;programs;Property;Protocols documentation;Psyche structure;Psychometrics;recruit;Research;Resources;retention rate;Risk;Risk Factors;Role;Sample Size;Science;sex;Siblings;Site;support network;trait;Uterus;Work

PROJECT_TITLE: Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) following autism families in ECHO Phase 2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Narrative Apicomplexan parasites cause the most devastating human infections, such as malaria, toxoplasmosis, and cryptosporidiosis. The rate of the parasite division determines the severity of the disease and the factors that control the replication of apicomplexan parasites are not well understood. This proposal will investigate the molecular basis for cell cycle control in Toxoplasma gondii and some factors identified in these studies may represent novel targets for future anti-parasitic therapeutics.

PI_NAMEs: SUVOROVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affect;Alveolar;Antiparasitic Agents;Apicomplexa;asexual;Biology;burden of illness;Cell Cycle;Cell Cycle Regulation;Cell division;Cell Nucleus;Characteristics;Chromosome Segregation;chronic infection;Closure by clamp;controlled release;Cryptosporidiosis;Cyclin-Dependent Kinases;Cytokinesis;Daughter;design;Disease;DNA;DNA biosynthesis;Drug resistance;Drug Targeting;druggable target;Engineering;Ensure;Eukaryota;Experimental Designs;experimental study;Focus Groups;Future;Genetic Materials;Human;human disease;Immunocompromised Host;Infection;Knowledge;Malaria;Mitosis;Modeling;Molecular;novel;Nuclear;nuclear division;opportunistic pathogen;Organism;Parasite resistance;Parasites;Phase;Phosphotransferases;pilot test;Plasmodium;Population;Positioning Attribute;Process;programs;Proteins;Regulation;Running;S phase;segregation;sensor;Severity of illness;Surface;temporal measurement;Testing;Therapeutic;tool;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Ubiquitination;Variant

PROJECT_TITLE: Deciphering the composite S-phase in Toxoplasma gondii


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: SURGERY

PHR: Narrative This proposal will address the fundamental unexplored questions of whether glyoxalase 1(GLO1) is a key player in tau-induced synaptic injury, tau pathology, and neuroinflammation, whether augmentation of GLO1 proves beneficial for clearance of tau and toxic metabolites, mitochondrial quality, and cognitive function as a therapeutic strategy in AD and ADRD, whether circulating serum and platelet AGEs-related metabolites associate with cerebral mitochondrial dysfunction, and whether these toxic metabolites can serve as risk factors/biomarkers for the onset and/or progression of early AD and age-related cognitive dysfunction.

PI_NAMEs: YAN, SHIRLEY SHIDU (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Advanced Glycosylation End Products;Affect;Age;age related;aged;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Attenuated;Biological Markers;Blood Platelets;Brain;Cerebral cortex;Cerebrum;cognitive function;Data;Disease;Disease Progression;DLG4 gene;Drug Metabolic Detoxication;Enzymes;follow-up;Functional disorder;Glutathione;glycation;Human;human subject;Impaired cognition;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Injury;insight;Lactoylglutathione Lyase;Link;loss of function;Mediating;Metabolism;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Mus;neuroinflammation;Neurons;neurotoxic;new therapeutic target;novel;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Phagocytosis;Pilot Projects;postsynaptic;presynaptic;Production;Protein Isoforms;Pyruvaldehyde;Regulation;respiratory protein;Risk Factors;Role;Serum;Signal Transduction;Stress;Synapses;Synapsins;synaptic failure;synaptic function;synaptic pruning;Synaptic Transmission;Synaptosomes;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Therapeutic

PROJECT_TITLE: Role of clearance of toxic metabolites in mitochondrial and tau pathology

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative We will study how the brain processes and organizes complex visual information. The results of this work will provide insights into neural circuitry that are relevant for the development of prosthetic devices and recovery of visual function.

PI_NAMEs: SMITH, SPENCER LAVERE (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adaptive Behaviors;Animals;Anterolateral;Area;area striata;Behavior;Behavioral;Brain;Brain region;Calcium;Code;Complex;Data;density;Dependence;Development;Exhibits;extrastriate visual cortex;Frequencies;Generations;Image;imaging system;Individual;insight;Investigation;Measurement;Measures;Medial;Modeling;Modernization;Motion;multi-photon;multiphoton imaging;Mus;neural;neural circuit;neural model;Neurons;Noise;novel;optic flow;optogenetics;Photic Stimulation;Population;Process;Prosthesis;Recovery;Resolution;response;segregation;Statistical Data Interpretation;Stimulus;Structure;System;Technology;Testing;Texture;Time;tool;two-photon;V1 neuron;virtual reality;Vision;Visual;Visual Cortex;visual information;visual processing;visual stimulus;Work

PROJECT_TITLE: Visual representations across cortical areas

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Maternal Health;Microbiome;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study examines the relationship between common microbiome perturbing exposures, the early life microbiome, and upper and lower airway health in children, while contributing unique diversity to the larger ECHO cohort. The knowledge gained from this proposal will inform clinical, public health, and policy interventions that will improve child health.

PI_NAMEs: BARRETT, EMILY S (contact);BLASER, MARTIN J;DOMINGUEZ-BELLO, MARIA GLORIA;HORTON, DANIEL BENJAMIN;JIMENEZ, MANUEL E;PALOMARES, KRISTY

PROJECT_TERMS: Acids;Address;Age;Airway Disease;Allergic rhinitis;Antibiotics;Asian;Asthma;Basic Science;Birth;Black race;Breast Feeding;Cesarean section;Child;Child Health;Childhood;Clinical;cohort;Communities;Conceptions;County;Development;Discipline of obstetrics;Disease;Disparity;Drug Exposure;early childhood;Education;Ensure;Environmental Exposure;epidemiology study;ethnic disparity;Ethnic Minority Women;Ethnic Origin;experience;Exposure to;feeding;Growth;Health;health disparity;High Prevalence;Hispanic;Immigrant;Immigrant community;Immune;Impairment;improved;Income;infancy;Infant;Infant Development;Infant formula;Infection;Insurance;Intervention;Intravenous;Knowledge;Life;Life Cycle Stages;life span;Literature;marginalized population;Maternal and Child Health;maternal microbiome;Mediating;Medicine;microbial;microbial signature;microbiome;microbiome alteration;microbiome composition;microbiome signature;microbiota;Modernization;Mothers;mouse model;Neonatal;neurodevelopment;New Brunswick;New Jersey;offspring;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;Policies;Population Heterogeneity;Population Study;Pregnancy;pregnant;prenatal;Prospective cohort;Prospective Studies;Protocols documentation;Public Health;public health intervention;Race;racial disparity;racial minority women;recruit;Reporting;Research;respiratory health;response;Risk;Role;Site;Skin;social determinants;sociodemographics;socioeconomic disparity;Time;Urbanization;Vaginal delivery procedure;Woman

PROJECT_TITLE: New Jersey ECHO


NIH_SPENDING_CATS: Immunotherapy

ORG_DEPT: PEDIATRICS

PHR: Project narrative Natural killer cells are immune cells that play a critical role in controlling viral infections and fighting cancer. This project aims to understand how one of the most commonly expressed cell surface receptors on human natural killer cells works to carry out these important functions.

PI_NAMEs: MACE, EMILY MARGARET (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Actin-Binding Protein;Actins;Activated Natural Killer Cell;Binding;Biochemical;Biological Process;Biology;biomarker identification;cancer immunotherapeutics;CD44 Antigens;Cell Adhesion;Cell Communication;cell fixing;cell killing;Cell Line;Cell membrane;cell motility;Cell Physiology;Cell Surface Receptors;cell type;Cells;Cellular biology;Complex;Cytoskeleton;cytotoxic;cytotoxicity;Data;density;Diffusion;Disease;Electrostatics;Extracellular Domain;fighting;Genetic;Glycocalyx;Glycoproteins;Health;Human;Immune;Immunoprecipitation;Immunotherapy;insight;Integrins;Label;Link;Literature;Lymphocyte;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Microdomains;Microscopy;migration;Modification;Molecular;Mus;Natural Killer Cells;NCAM1 gene;Neural Cell Adhesion Molecules;Neurons;Neurophysiology - biologic function;Phenotype;Phosphotransferases;Physiological;Play;polymerization;Polymers;Polysialic Acid;Population;prevent;Property;Protein Isoforms;Proteins;receptor;recruit;Regulation;Role;scaffold;Signal Transduction;Signaling Protein;single molecule;Site;Spectrin;spectrin-binding proteins;Testing;tool;Translating;tumor;Virus Diseases;Work

PROJECT_TITLE: Defining the functional role of CD56 on human natural killer cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Human immunodeficiency virus (HIV-1) infection leads to the deadly disease acquired immunodeficiency syndrome (AIDS). During natural infection of HIV-1, the vast majority of viral DNAs exist in an extrachromosomal unintegrated state. We propose to study the transcriptional regulation of unintegrated HIV-1 DNA. Upon conclusion, this research will provide new targets for the treatment and cure of HIV-1 infected individuals.

PI_NAMEs: ZHU, YIPING  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;antagonist;ATP phosphohydrolase;Binding;Cell Nucleus;Cells;Chromatin;Chromatin Structure;co-infection;cofactor;cohesin;Complex;CRISPR/Cas technology;CSPG6 gene;Cytoplasm;Disease;Dissociation;DNA;DNA Integration;Epigenetic Process;epigenetic silencing;Euchromatin;Gene Expression;Genes;Genetic Transcription;Genome;Goals;Heterochromatin;Histones;HIV;Host Defense;Human T-lymphotropic virus 1;Individual;Infection;Inherited;Integration Host Factors;Intestines;Invaded;Knock-out;Knowledge;Maintenance;Mediating;microbial;Molecular;Physical condensation;Play;Primate Lentiviruses;protein degradation;Research;Resources;Role;screening;Structure;System;T-Lymphocyte;Taxes;Testing;Transcriptional Activation;Transcriptional Regulation;Viral;viral DNA;Viral Genes;Viral Pathogenesis;Viral Proteins;viral transmission;Virus;Virus Diseases;Virus Integration;Virus Replication;vpr Gene Products

PROJECT_TITLE: SMC1A/3 cohesin complex-mediated silencing of unintegrated HIV-1 DNA and the antagonism by Vpr

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE There is an urgent need for biomarkers of human aging. This project uses Artificial Intelligence to analyze data from multiple genomic assays to identify novel biomarkers of aging, some of which have the potential to be compelling targets of intervention.

PI_NAMEs: EVANS, DANIEL SPENCER;LI, HAO  (contact)

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Acceleration;age related chronic disease;Aging;aging biomarker;aging population;aging process;Artificial Intelligence;artificial intelligence method;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biological Testing;Biology;Biology of Aging;biomarker identification;biomarker validation;Cell Culture Techniques;Centenarian;Clinical;Clinical Research;cohort;Cohort Studies;Collection;Complex;Computational Biology;Data;data harmonization;data integration;data management;Data Set;deep neural network;design;Development;Disease;drug development;Epidemiology;experimental study;extreme human longevity;Family;follow-up;Foundations;Framingham Heart Study;Funding;genetic epidemiology;Genomics;healthy aging;high dimensionality;Human;human data;Intervention;Investments;Knowledge;Life Expectancy;life span;Longevity;Machine Learning;Mendelian randomization;Modeling;Molecular;molecular marker;Multiomic Data;multiple omics;Mus;neural network architecture;Neural Network Simulation;novel;novel marker;Outcome;outcome prediction;Pathway interactions;Performance;Phenotype;Phylogenetic Analysis;Physiology;Predictive Factor;predictive marker;Prognostic Marker;Proteins;Research;Research Design;risk mitigation;Testing;Time;trait

PROJECT_TITLE: Identifying molecular traits associated with extreme human longevity using an AI based integrative approach


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Addressing the ongoing maternal health crisis in this country is not possible without centering Black birthing individuals. Nowhere are racial inequities and poor maternal health in starker relief than in Louisiana and Mississippi, which consistently rank last in the country on several health indicators. Urgently needed are interventions at multiple levels, coupled with sustained implementation of programs and policies that have been proven to promote pregnancy health. The Southern Center for Maternal Health Equity is a partnership among the National Birth Equity Collaborative (NBEC), Tulane University, and Ochsner Health System. It joins NBEC’s focus on optimizing Black maternal health through establishing the community as the experts on their health; Tulane’s technical expertise in epidemiology, translational research, and health policy and economics; and Ochsner’s depth in clinical and outcomes research and community-rooted network of clinical care. The overall objective of the Center is to improve maternal health through testing community-prioritized and co- developed strategies. A research center will be established, embedded within ongoing community partnerships and the existing research, training, and outreach infrastructure, to build and strengthen maternal health. The center’s overarching focus is addressing root causes (bias, insufficient access to care, health and social policy) of maternal morbidity and mortality, with a focus on Black women in the Gulf South. The overall research theme is assessing implementation of existing evidence-based strategies and building the evidence base for and translation of novel strategies that drive innovative models of care tailored to the community priorities and needs. The objective of the Research Projects is to assess interpersonal, health system, and policy interventions that combine to create a multilevel approach to advancing maternal health, and evaluate these strategies from cross-cutting perspectives, including cost-effectiveness, clinical care, and health equity. This will be achieved through conducting three research projects: a trial in a large health care system of a multifaceted behavior change intervention to reduce biased treatment (interpersonal level; RP1); adapting and evaluating an enhanced remote monitoring package in low maternity care access areas (health care provision level; RP2); and assessing the effects of Medicaid postpartum extension legislation on maternal health (policy level; RP3). The objective of the Training Core is to provide innovative and transdisciplinary training for early career scholars, aimed at developing a research workforce that can reduce maternal morbidity and mortality locally, regionally, and nationally. The objective of the Community Partners Core is to incorporate community priorities, vision, and expertise in all areas of the project, and to return results and benefits directly to impacted communities. The transdisciplinary research and training made possible by this U54, in collaboration with the other awarded centers and the data and implementation hubs, will contribute to innovative approaches that will reduce maternal deaths and severe maternal morbidity in communities most at risk.

PI_NAMEs: BIGGIO, JOSEPH RAMON;HARVILLE, EMILY WHEELER (contact);PEREZ, SUSAN

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Advocacy;Aptitude;Area;Award;behavior change;Birth;Black race;black women;career;Caring;Clinical;clinical care;Clinical Research;Collaborations;Communities;community partners;community partnership;cost effectiveness;Country;Coupled;Data;Development;Education;effective intervention;Epidemiology;Equity;evidence base;Goals;Health;health care availability;health economics;health equity;Health Policy;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;implementation evaluation;Improve Access;improved;Individual;Infant Health;Infrastructure;innovation;Intervention;Louisiana;Maternal complication;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Medicaid;Mississippi;Modeling;novel strategies;Outcomes Research;outreach;Persons;Policies;Positioning Attribute;post pregnancy;Postpartum Period;Pregnancy;pregnancy health;prevent;programs;racial disparity;remote monitoring;reproductive epidemiology;Reproductive Health;Research;Research Project Grants;Risk;severe maternal morbidity;social;social epidemiology;Social Policies;Statutes and Laws;Technical Expertise;Testing;Training;Training and Education;training opportunity;Translating;Translational Research;Translations;Universities;Vision;Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F(71)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: PEREZ, SUSAN  (contact)

PROJECT_TERMS: Address;Adoption;American College of Obstetricians and Gynecologists;Black race;care systems;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Client satisfaction;Clinical;clinically relevant;community led intervention;community organizations;community partnership;comorbidity;Conceptions;Continuity of Patient Care;Country;Data;Death Rate;Developed Countries;Discrimination;Disparate;Disparity;disparity reduction;Educational Intervention;Electronic Health Record;Emotional;Equity;Ethnic Minority Women;Ethnic Origin;evidence base;Evidence based intervention;experience;Goals;Harm Reduction;health assessment;health care settings;Health Personnel;Healthcare Systems;Hospitals;implementation intervention;implicit bias;improved;Incidence;Individual;Inequity;Institution;Intervention;Interview;Link;maltreatment;Maternal Health;Maternal health equity;Maternal Mortality;maternal outcome;Measures;mortality;Mothers;multi-component intervention;Not Hispanic or Latino;Outcome;outcome disparities;patient safety;Patients;Postpartum Period;Provider;Public Health;Race;racial bias;racial minority women;racism;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;satisfaction;Surveys;Training;Uncertainty;United States;Woman;Work

PROJECT_TITLE: RP1 _NBEC


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: HARVILLE, EMILY WHEELER (contact)

PROJECT_TERMS: Address;Adoption;Age;Area;Birth;Black race;black women;Blood Pressure;Caring;Client satisfaction;Communities;community collaboration;County;Data;Data Collection;design;digital;effectiveness/implementation hybrid;electronic health record system;Eligibility Determination;empowerment;Ethnic Origin;experience;Focus Groups;geographic disparity;Goals;Health;health care availability;Health Services Accessibility;high risk;Home;Hospitals;implementation barriers;implementation evaluation;implementation intervention;implementation outcomes;Improve Access;improved;Infrastructure;innovation;Internet;Intervention;Interview;Leadership;Louisiana;Manuals;Maternal Health;Maternal health equity;Maternal Health Services;Modeling;Monitor;mortality risk;Not Hispanic or Latino;obstetric care;obstetric services;Outcome;Patient Outcomes Assessments;Patients;Persons;Phase;Postpartum Period;Poverty;Pregnancy;pregnant;Premature Birth;Procedures;Process;programs;Protocols documentation;Provider;Race;racial disparity;remote health care;Rural;rural area;Sampling;Services;Site;Socioeconomic Status;Specialist;Technology;Testing;tool;Training;Underinsured;Underserved Population;Weight;Woman


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: EUGENE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Exfoliative toxins produced by the bacterium Staphylococcus aureus cause severe blistering of the skin leading to life-threatening infections. These toxins are only effective against a specific group of host species, but the barriers that limit toxin activity in different species remain unclear. This study will define the genetic and molecular determinants toxin specificity in order to anticipate potential future disease spillover events.

PI_NAMEs: BARBER, MATTHEW FREDERICK (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Amino Acids;Animals;Bacteria;Bacterial Infections;Binding;Biochemical;Biological Assay;Bulla;Cadherins;Cell Adhesion;Cells;Chromosome Mapping;Collection;combinatorial;Complex;Crystallography;design;desmoglein;desmoglein 1;Desmosomes;Development;Disease;Disease Outbreaks;Endocarditis;Epidermis;Evolution;Exfoliatins;Exfoliative Toxins;Future;Genes;Genetic;Genetic Drift;Genetic Variation;Genus staphylococcus;Goals;Human;human disease;human pathogen;Impetigo;improved;in vitro Assay;Infection;Infectious Skin Diseases;Integration Host Factors;Intercellular Junctions;Investigation;Knowledge;Life;Maps;Measures;Mediating;Membrane Proteins;Modeling;Molecular;Mutagenesis;mutant;Mutation;Natural Selections;nonhuman primate;novel therapeutics;Osteomyelitis;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathogenicity;Peptide Hydrolases;Pneumonia;Positioning Attribute;Predisposition;prevent;Primates;Production;Proteins;Recombinants;Resolution;Risk Assessment;Sepsis;Site;Skin;skin barrier;skin disorder;Soft Tissue Infections;Specificity;spillover event;Staphylococcal Scalded Skin Syndrome;Staphylococcus aureus;Surface;System;Testing;Toxin;Tropism;Variant;Virulence;Virulence Factors;Work;Zoonoses

PROJECT_TITLE: Host range determinants of bacterial exfoliative toxins

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention;Violence Research

PHR: PROJECT NARRATIVE Effective suicide prevention programs that can be implemented in real-world military settings are urgently needed to address the significant and growing problem of military suicides. This study tests and prepares the Wingman-Connect Program for large-scale delivery in the US Air Force (USAF). If study hypotheses are supported, Wingman-Connect will be ready for scale-up across the Air Force and potentially to other military branches, providing our nation's military with the first universal intervention that reduces suicidal behavior, depression, and occupational problems.

PI_NAMEs: WYMAN, PETER A (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: active control;Address;Air;Air Force Personnel;base;career;Climate;cohesion;Communication;computerized;coping;Data;design;Diffusion;digital;Effectiveness;effectiveness study;effectiveness testing;effectiveness trial;effectiveness/implementation trial;experience;Exposure to;follow-up;Funding;Health;Human Resources;implementation determinants;implementation measures;implementation outcomes;Individual;Intervention;Leadership;Mediating;Mediation;Mediator;Mental Depression;Military Personnel;Morale;Occupational;Outcome;Patient Self-Report;Periodicals;Phase;Population;Prevention approach;Prevention program;Process;programs;Randomized;Records;reducing suicide;remediation;Reporting;Research Personnel;scale up;secondary analysis;Severities;skills;social attachment;Social Network;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Techniques;Testing;theories;therapy development;Training;translational pipeline;universal prevention;usability;Vision;Work

PROJECT_TITLE: Effectiveness Trial of Wingman-Connect Implemented Across Career Phases

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Narrative: Attention deficit is one of the most common developmental problems in the general population. Focusing on the frontal, thalamus and cerebellum of the brain, this study investigates how brain structural and functional features underlie the attention deficit and finds genetic factors regulating these brain attributes. Finally, this study will build a prediction model for the attention deficit using brain attributes together with genetic and environmental factors.

PI_NAMEs: JI, SHIHAO ;LIU, JINGYU  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adolescent;Affect;Algorithms;Anterior;Attention;Attention deficit hyperactivity disorder;Attentional deficit;Back;Behavior assessment;Bilateral;Brain;Brain imaging;Cerebellum;Cognition;cognitive development;cohort;Data;data mining;data resource;deep learning algorithm;Demographic Factors;Development;Dimensions;Dorsal;Emotional;Environment;Environmental Risk Factor;executive function;follow-up;frontal lobe;Functional Magnetic Resonance Imaging;General Population;Genes;Genetic;genetic association;Genomics;Goals;gray matter;high risk;Image;imaging genetics;Impaired cognition;Impairment;Individual;Inferior;Investigation;Knowledge;Learning;machine learning method;Magnetic Resonance Imaging;Measures;Mediating;Mental disorders;Mental Health;Methods;model building;Modeling;multimodal data;multimodal neuroimaging;multimodality;Nervous System Disorder;Neurocognition;Neurocognitive;neuroimaging;neuromechanism;neuronal circuitry;Parietal;Patients;Performance;Philadelphia;predictive modeling;processing speed;Properdin;Psychopathology;Reporting;Research;response;Rest;Risk;Role;Short-Term Memory;social factors;sociodemographic factors;sociodemographics;Specific qualifier value;Speed;Structure;Symptoms;Techniques;Testing;Thalamic structure;trait;transfer learning;Variant;vigilance;white matter

PROJECT_TITLE: Frontal-thalamo-cerebellar circuitry of attention deficit via imaging-genetic-environmental analyses

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Depression;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

PHR: Narrative We propose three waves of health policy evaluations (early 2022-2023, middle 2024-2025, and late 2026- 2027) of the Medicaid postpartum extension (MPE) and postpartum depression screening mandate in Louisiana, compared to Mississippi. The intended outcome will be to evaluate the effectiveness and contextual factors of implementation strategies that aim to improve maternal postpartum health and health equity. This study will generate urgently needed data on practical, robust, and sustainable population-targeted strategies to improve maternal health outcomes, reduce maternal health risks, and eliminate maternal health disparities in the United States.

PI_NAMEs: SHI, LIZHENG  (contact)

PROJECT_TERMS: Adopted;Affect;American;anti-depressive agents;beneficiary;Birth;Blood Glucose;Blood Pressure;Blood Pressure Monitors;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Collaborations;community based participatory research;Complex;Complications of Diabetes Mellitus;contextual factors;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Data;Depression screen;Diabetes Mellitus;Diagnosis;Disparity;Eclampsia;Effectiveness;effectiveness evaluation;effectiveness measure;Electronic Health Record;empowerment;Equity;ethnic minority;Evaluation;experience;follow-up;Funding;Future;Gestational Diabetes;glucose monitor;Goals;Health;Health behavior and outcomes;health care delivery;health care service utilization;Health Disparities Research;health disparity;health equity;health inequalities;Health Personnel;Health Policy;Health system;Healthcare;high risk;Hypertension;implementation strategy;improved;Individual;Kidney Diseases;Life;Link;Louisiana;marginalization;Maternal Health;Maternal health equity;Measures;Medicaid;Mental disorders;Mental Health;Mississippi;Non-Insulin-Dependent Diabetes Mellitus;Outcome;outcome disparities;Outcome Measure;patient engagement;patient oriented;Patients;Persons;Policies;Policy Analysis;Postnatal Care;postpartum care;Postpartum Depression;postpartum health;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Preventive service;Provider;Psyche structure;racial minority;Recommendation;Risk;Risk Factors;scale up;screening;social;socioeconomic disadvantage;Structure;synergism;Target Populations;United States;Vulnerable Populations

PROJECT_TITLE: Impact of Medicaid Postpartum Coverage Extension and Mandated Postpartum Depression Screening on Care for Gestational Diabetes and Pregnancy-Induced Hypertension


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Diabetes is a complex disease that is defined by poor control of blood sugar. Loss of blood sugar control is related to a poor functioning pancreas, which is worsened in individuals who yo-yo diet, or weight cycle. The goal of this project is to identify the mechanisms of how body weight fluctuations evoked by weight cycling worsen pancreatic function and blood sugar control.

PI_NAMEs: WINN, NATHAN C (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Animals;Antioxidants;attenuation;Automobile Driving;Beta Cell;Biological Assay;Blood capillaries;Blood flow;Blood Glucose;blood glucose regulation;Body Weight;Body Weight decreased;Caloric Restriction;Cardiometabolic Disease;Cell Physiology;Cell Respiration;Cell Survival;Cells;Chronic;Citric Acid Cycle;Closure by clamp;Compensation;Complex;Coupled;Coupling;Crista ampullaris;Data;Development;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Effectiveness;energy balance;euglycemia;Exocytosis;experimental study;Free Radicals;Functional disorder;genetic signature;Glucose;Glucose Clamp;Glucose Intolerance;glucose tolerance;Glycerides;Goals;Hemorrhage;High Fat Diet;Hormones;Human;Hyperglycemia;Hyperinsulinism;Impairment;improved;in vivo;indexing;Individual;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;intravenous glucose tolerance test;islet;Islets of Langerhans Transplantation;Isotopes;Knowledge;Label;life span;Link;mass spectrometric imaging;Measures;Membrane;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial metabolism;Mitochondrial Swelling;Modification;Morphology;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;nutrient metabolism;Obese Mice;Obesity;Overnutrition;Oxidation-Reduction;Oxidative Stress;Pancreas;Pattern;Peripheral;pharmacologic;Physiological;Potassium Channel;Production;Reactive Oxygen Species;Regulation;Resolution;respiratory;response;Risk;Risk Factors;Rodent;Sampling;Signal Transduction;small molecule inhibitor;stable isotope;Structure;Structure of beta Cell of islet;Techniques;Testing;Thinness;Tracer;Transplantation;TXNIP gene;Weight;Weight Gain;weight maintenance

PROJECT_TITLE: Uncovering mechanisms of pancreatic adaptability to weight cycling

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: JAH, ZAINAB  (contact)

PROJECT_TERMS: Achievement;Address;Advocacy;Agreement;anti-racism;Birth;Black race;black women;care outcomes;Caring;Collaborations;Communication;Communities;Community Healthcare;community organizations;community partners;community-centered;Complex;Data Collection;data management;design;Discrimination;Disparity;disparity reduction;Ensure;Equity;Evaluation;Exclusion;experience;forging;Goals;Grant;hands-on learning;Health;Health Personnel;Health system;Healthcare;Healthcare Systems;improved;Institution;Intervention;Knowledge;laboratory experience;Leadership;Learning;Lived experience;Maternal health equity;Maternal Mortality;Methods;Mothers;Outcome;Periodicals;Persons;Policies;Population;Positioning Attribute;Prevention;programs;racial disparity;Recording of previous events;remote health care;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Self-Examination;severe maternal morbidity;Stereotyping;success;System;Target Populations;Time;Training;Training Programs;Translating;Translations;Voice;Work;Writing

PROJECT_TITLE: Community Partners

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: The major causes of death and disability in the US have an even greater negative health impact in Oklahoma, particularly for rural and tribal citizens. To reduce the impact of these diseases on individuals and communities, we need to make new discoveries and accelerate their implementation into clinical practice. This project brings together clinical researchers, health professionals, community organizations, and scientific infrastructure to address the state’s top health disparities: cancer, diabetes, obesity, cardiovascular disease, substance abuse, mental health, arthritis and autoimmunity, child health, and positive health choices.

PI_NAMEs: JAMES, JUDITH A (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Acceleration;Address;Adoption;Aging;Aliquot;American Indian Tribe;American Indians;Area;Arthritis;Autoimmunity;Award;Behavior;biobank;Biometry;burden of illness;Caliber;Cardiovascular Diseases;cardiovascular risk factor;career;catalyst;Cause of Death;Center for Translational Science Activities;Certification;Cessation of life;Child Health;Chronic Disease;Clinical;Clinical Data;clinical data warehouse;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engaged research;community engagement;Community Networks;community organizations;community partnership;community-centered;comparative;COVID-19 test;Development;Development Plans;Diabetes Mellitus;disability;Discipline;Disease;Disparity;Dissemination and Implementation;early childhood;Epidemiology;Evidence based practice;experience;Eye;Fostering;Foundations;Funding;Goals;Grant;Health;health disparity;health equity;Health Priorities;Health Professional;Health system;High Prevalence;implementation research;improved;improved outcome;Individual;Industry;Infrastructure;Institution;interest;Leadership;Life;Life Expectancy;Malignant Neoplasms;medical schools;Mental Health;Mentors;minority investigator;Mission;Modeling;Morbidity - disease rate;mortality;Not Hispanic or Latino;nutrition;Obesity;Oklahoma;online resource;Opioid;opioid epidemic;opioid overdose;Outcome;overdose death;pandemic impact;Patient Care;Patients;Physical activity;Population;Practice based research;practice-based research network;premature;prescription opioid;primary care practice;Privatization;Process;Productivity;programs;Public Health;RADx Underserved Populations;recruit;Registries;repository;Research;Research Infrastructure;Research Personnel;Resources;Risk Reduction;Rural;Rural Community;Rural Health;Rural Population;Sampling;Scientist;screening;Smoking;social health determinants;Speed;Substance abuse problem;success;Surveys;teen birth;Tobacco;Tobacco use;Tobacco Use Cessation;Training;Training and Infrastructure;Translational Research;translational research program;Tribal group;tribal health;tribal Nation;Tribes;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Vision;web portal;Work;Writing

PROJECT_TITLE: Oklahoma Shared Clinical and Translational Resources


ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE: OVERALL COMPONENT In this proposal, we aim to address key social-structural risk factors for racial disparities in maternal morbidity in Southeastern Wisconsin identified by our research community and community partners. These risk factors include housing instability, medical mistrust, and fragmented access to preventative care postpartum.

PI_NAMEs: DICKSON-GOMEZ, JULIA B;OLSON, JESSICA M;PALATNIK, ANNA  (contact);WILLIAMS, JONI STROM

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Academic skills;access disparities;Address;Adopted;Advocate;Birth;Cardiovascular system;career;Caring;Cities;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community collaboration;community engaged research;Community Health Aides;community involvement;community organizations;community partners;community setting;Conceptions;design;early pregnancy;Ensure;Environment;Equity;ethnic disparity;Exposure to;Goals;Health;health care service;health disparity;Health equity research;health inequalities;Health Services Accessibility;Health system;Home;Housing;housing instability;improved;Inequity;inner city;innovation;Intervention;Low income;Maternal Deprivation;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Medicaid;Medical;member;Modeling;Neighborhoods;Outcome;Persons;Policies;Policy Maker;population health;Postdoctoral Fellow;postpartum care;Postpartum Period;Poverty;Pregnancy;Preventive care;racial disparity;Research;Research Personnel;Research Project Grants;residential segregation;Risk Factors;Role;Scientist;segregation;Services;severe maternal morbidity;social;social health determinants;social structure;Structural Racism;synergism;telemonitoring;Training;Trust;Wisconsin;Work

PROJECT_TITLE: Addressing Key Social-Structural Risk Factors for Racial Disparities in Maternal Morbidity in Southeastern Wisconsin (ASCEND WI)


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;aging brain;Applications Grants;Arthritis;Autoimmunity;brain research;Budgets;Cancer Center;Cardiovascular Diseases;career;catalyst;Cherokee Nation;Chickasaw Nation;Child Health;Choctaw Nation of Oklahoma;Cities;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communication;Communications Personnel;Communities;Community Medicine;community organizations;Community Participation;community partners;Consultations;Development;Diabetes Mellitus;Educational workshop;Ensure;Evidence based practice;Eye;Fostering;Foundations;Funding;Geroscience;Goals;Grant;Health;health equity;Health Professional;Health Promotion;Health Sciences;Healthcare;Home;improved;Information Resources;Infrastructure;Institution;Investments;Laboratories;Lead;Leadership;Malignant Neoplasms;Manuscripts;Marketing;Medical center;Medical Research;meetings;Mental Health;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;Newsletter;Obesity;Oklahoma;Online Systems;patient population;Patients;Performance;Personnel Management;Physicians;podcast;Policies;Practice based research;Press Releases;Primary Health Care;Privatization;Procedures;Process;Productivity;programs;Public Health;Publications;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;response;Schools;Services;Strategic Planning;Substance abuse problem;success;Supervision;symposium;synergism;Teleconferences;tool;Training;Training and Infrastructure;Translational Research;translational research program;tribal community;tribal health;tribal Nation;Tribes;Underrepresented Populations;Underserved Population;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;webinar;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: BAZZANO, ALESSANDRA  (contact)

PROJECT_TERMS: Abate;Address;Adoption;Affect;Applied Research;Behavioral;Benchmarking;Biological;Biomedical Research;Birth;Black Populations;Black race;black women;career;career development;Career Ladders;Clinical;clinical care;clinically relevant;cohort;Communities;community engagement;Competence;Country;design;Development;Development Plans;doctoral student;Education;Educational Curriculum;Educational workshop;Environmental Risk Factor;Equity;ethnic minority;evidence base;Faculty;faculty support;Fostering;Foundations;Geography;Government;Grant;hands on research;Health;health equity;health inequalities;Health system;implementation evaluation;improved;improved outcome;Individual;Inequity;innovation;Institution;Intervention;Justice;Knowledge;Life;Lived experience;Louisiana;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;member;mentoring community;Mentors;Methods;Minority Groups;Mission;Mississippi;next generation;novel;novel strategies;Outcome;pedagogy;Peer Review;Perinatal;Perinatal Care;perinatal health;perinatal morbidity;Persons;Policies;Population;Positioning Attribute;post pregnancy;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Publications;racial disparity;racial minority;Reduce health disparities;reproductive;Reproductive Health;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;severe maternal morbidity;skills;social determinants;sociocultural determinant;Socioeconomic Status;structural determinants;support network;System;Technical Expertise;Testing;Training;Training and Education;training opportunity;Training Programs;trend;Underrepresented Populations;Universities;Voice

PROJECT_TITLE: Southern Center for Maternal Health Equity -Training Component


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Center for Advancing Point of Care Technologies (CAPCaT) in Heart, Lung and Blood Diseases will develop and optimize novel point of care and home-based technologies to improve the diagnosis and management of heart, lung, blood and sleep (HLBS) disorders. CAPCaT will accomplish this goal by integrating scientific, technology incubation, business development, trial design, and clinical expertise to identify promising medical products and mentor small companies through alliances with external partners and large companies.

PI_NAMEs: BUCHHOLZ, BRYAN O;HAFER, NATHANIEL SCOTT;MCMANUS, DAVID D. (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;acute care;Address;Adoption;Advisory Committees;Affect;American;Automobile Driving;Blood;Businesses;Cardiovascular system;Caregivers;Caring;Cessation of life;Client satisfaction;Clinic;Clinical;clinical development;Clinical Research;commercialization;Communication;community engagement;Community Health;cost;COVID-19 pandemic;COVID-19 testing;Data;Decision Making;design;Development;Device or Instrument Development;Diagnosis;Disease;Disparity;Engineering;Environment;Equitable healthcare;evidence base;experience;Family;Funding;Goals;Grant;Health;health care availability;health care quality;health equity;health management;Health Personnel;Health Professional;Health Promotion;Health system;Healthcare;Heart;Heart Diseases;Hematological Disease;Home;home test;improved;Income;Incubated;Incubators;industry partner;innovation;Intellectual Property;Knowledge;Legal patent;Life;Lung;Lung Diseases;marginalized population;Marketing;Massachusetts;Medical;Medical Device;medical schools;Mentors;Methodology;Modeling;Morbidity - disease rate;mortality;Needs Assessment;new technology;novel;Outcome;Pathway interactions;patient engagement;patient oriented;Patients;personalized management;point of care;Point of Care Technology;Policy Maker;Population Heterogeneity;prevent;Prevention;Process;programs;Provider;Quality of Care;Research;research clinical testing;Research Personnel;Resource-limited setting;Resources;Risk;Running;Sleep;Sleep Disorders;success;System;Technology;technology research and development;Telemedicine;Therapeutic;Time;tool;Training;trend;trial design;Underserved Population;United States National Institutes of Health;Universities;virtual healthcare;Vision;Work

PROJECT_TITLE: The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep Diseases


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: VANWAGONER, TIMOTHY M (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alaska Native;American Indians;Area;Arthritis;Award;Basic Science;bridge program;Cardiovascular Diseases;Cardiovascular system;career development;Career Mobility;Categories;Centers of Research Excellence;Cessation of life;Child Health;Clinical;clinical care;clinical development;clinical infrastructure;Clinical Research;Clinical Sciences;Communities;Community Developments;community engaged research;Country;County;Critiques;Dedications;Development;Diabetes Mellitus;Diagnosis;disability;Disease;Disparity;Environment;equity, diversity, and inclusion;Evaluation;Extramural Activities;Faculty;Feedback;Female;Financial Support;Fostering;Foundations;Funding;Funding Agency;Funding Opportunities;Future;Generations;Goals;Grant;Growth and Development function;Health;Health Benefit;health disparity;health outcome disparity;Health Priorities;Howard Temin Award;improved;Infrastructure;innovation;Institution;interest;Investments;K-Series Research Career Programs;Leadership;Life Expectancy;Malignant Neoplasms;Medical Research;medical schools;meetings;member;Mentors;Mentorship;Minority Groups;Mission;multidisciplinary;novel;Obesity;Oklahoma;Outcome;Pathway interactions;Patients;peer coaching;Personal Satisfaction;Phase Transition;Pilot Projects;Population;Positioning Attribute;practical application;Prevalence;Prevention;primary care provider;Principal Investigator;Productivity;programs;Publishing;Qualifying;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;rural dwellers;Rural Population;Scientist;Secure;Severities;skills;Source;Structure;substance use;success;Talents;Testing;Tobacco use;Training;Translating;Translational Research;translational research program;tribal institution;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pilot Projects Program


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE ELEVATE CENTER Substance use and mental health disorders are the leading cause of maternal deaths in the U.S., and individuals living in rural communities and those who identify as Native American or Alaska Native are disproportionately affected. The ELEVATE Maternal Health Center of Excellence will complete three research projects focused on reducing maternal morbidity from substance use disorder. Information gleaned from these projects will then be disseminated across Utah, and nationally, to improve outcomes for pregnant and postpartum people with substance use disorder with a broad goal of reducing maternal morbidity.

PI_NAMEs: METZ, TORRI D (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Accidents;Accounting;Active Learning;addiction;Address;Adverse effects;Affect;Alaska Native;American Indians;Caring;Cessation of life;Clinic;Collaborations;Communities;community engagement;community led intervention;community partners;community partnership;community setting;Dependence;Discipline of obstetrics;Discrimination;Disparity;disparity reduction;Drug usage;Educational Curriculum;effectiveness/implementation trial;Elements;Equity;experience;Family;future implementation;Glean;Goals;health training;Healthcare;implementation science;improved outcome;Individual;informant;Infrastructure;Inpatients;Intervention;Interview;Leadership;Learning;Link;Lived experience;Location;Maternal Health;maternal morbidity;Maternal Mortality;Medical Care Team;Medicine;member;Mental disorders;Methods;Mission;Morbidity - disease rate;Mothers;multidisciplinary;Names;Native Americans;next generation;Outpatients;Overdose;Patient-Focused Outcomes;Perinatal;Perinatal Care;Persons;Pharmaceutical Preparations;Population;Populations at Risk;Postpartum Period;Pregnancy;pregnancy related death;pregnant;programs;Provider;Recovery;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;response;Review Committee;Role;Rural;Rural Community;rural setting;scale up;Scientist;simulation;substance use;Substance Use Disorder;success;Suicide;System;Testing;Time;tool;Trainers Training;Training;Tribes;Universities;Utah;Work

PROJECT_TITLE: ELEVATE Center: Reduction of Maternal Morbidity from Substance Use Disorder in Utah


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: DICKSON-GOMEZ, JULIA B (contact)

PROJECT_TERMS: Acute;Address;Adult;Advocate;Affect;allostatic load;Area;Attention;Biological;Biological Markers;Birth;Black race;Case Management;Categories;Characteristics;Child;Chronic;Church;Cities;Communities;community advisory board;Continuity of Patient Care;County;COVID-19 pandemic;deprivation;disabled;Disparity;Economics;Electronic Health Record;Eligibility Determination;Emergency Situation;ethnic segregation;experience;Family;Friends;Funding;Future Generations;Health;health disparity;health inequalities;Health Status;Healthcare;Homelessness;Housing;housing instability;improved;Income;Indigenous;Individual;Infant;infant outcome;Institutional Racism;Knowledge;Longitudinal Surveys;Low income;Low Income Population;lower income families;Maps;Marketing;Maternal Deprivation;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;Measures;member;Mental Health;Mental Health Services;metropolitan;Morbidity - disease rate;mortality;Mothers;Neighborhoods;Outcome;Participant;Persons;Physical assessment;physical conditioning;physical health service;Policies;Population;Postpartum Period;Poverty;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;programs;Psychiatric Social Work;racial disparity;racial health disparity;Racial Segregation;Recording of previous events;Research;residential segregation;Risk;Risk Factors;Sampling;Screening procedure;Second Pregnancy Trimester;Section 8;segregation;Services;Shelter facility;Site;social health determinants;social structure;Social Work;Stress;structural determinants;substance use;supported housing;Surveys;Third Pregnancy Trimester;Time;transitional housing;U.S. Department of Housing and Urban Development;Veterans;Visit;voucher;Wisconsin;Work

PROJECT_TITLE: The effect of HOusing instability and neighborhood deprivation on Maternal hEalth-HOME


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative The process of learning to communicate and interact with others by combining sensory information with motor skills is referred to as perceptual motor development, and deficits in this process are a hallmark of children with autism spectrum disorders and fragile X syndrome. The proposed work uses social tadpoles to investigate the role of dopamine and the fragile X protein in regulating how infants recognize their caregivers and communicate their needs with motor displays. This research fills a critical need for understanding the basic brain mechanisms related to perception and motor behaviors important for social development.

PI_NAMEs: O'CONNELL, LAUREN A (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Ablation;Address;Afferent Neurons;Animals;autistic children;Behavior;Behavioral;Behavioral Paradigm;Brain;Brain region;Caregivers;cell type;Cells;Child;cognitive development;Communication;Corpus striatum structure;Cues;Cyclic GMP;Dancing;Data;Development;Disease;Dopamine;dopaminergic neuron;Drug Targeting;Exhibits;experimental study;FMR1 gene;follow-up;Food;Foundations;Fragile X Syndrome;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Human;Imaging Device;in vivo imaging;Infant;Infant Development;insight;Knock-out;knockout animal;Knowledge;Laboratory Animals;Lead;Learning;Mammals;Measures;Molecular;Mothers;Motor;motor behavior;motor disorder;Motor output;Motor Skills;Movement;neonate;Nervous System;neural;neural circuit;neurogenetics;Neurons;novel;Nucleus Accumbens;Olfactory Learning;Olfactory Pathways;Organism;Parents;Perception;Personal Satisfaction;Process;Proteins;pup;Recovery;Regulation;Research;response;Role;Sensory;Signal Pathway;Signal Transduction;social;social attachment;Social Development;Social Environment;social organization;stem;Synapses;Tadpoles;Testing;tool;Vertebrates;Visual;Visualization;Work

PROJECT_TITLE: Dopamine regulation of infant perceptual motor development and communication

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This proposal is the first to iteratively develop, refine, and establish the feasibility and acceptability of a dyadic psychological intervention, specifically developed for socioeconomically disadvantaged older patients and their family care- partners during a post-acute stay in a skilled nursing facility (SNF). By enhancing coping capacity and reducing psychological distress among dyads during this critical window for psychological intervention (i.e., during and immediately after a SNF stay), the novel intervention developed in this proposal may also lead to positive health outcomes, like improved rehabilitation efficacy, care transitions, and long-term wellness as well as decreased risk of avoidable re-hospitalization among the high-need populations of dual-eligible patients and their family care-partners.

PI_NAMEs: PLYS, EVAN  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Address;Adherence;Adoption;Anxiety;Area;arm;Award;beneficiary;Care given by nurses;care preference;career;Caregivers;Caring;Chronic;Client satisfaction;Clinical;Clinical Trials;Communities;Conduct Clinical Trials;coping;Coping Skills;Data;design;Development;Disparity;Dissemination and Implementation;Distress;dual eligible;Educational Status;Effectiveness;effectiveness trial;efficacy testing;Ensure;Environment;Equity;Evidence based intervention;Expectancy;experience;Family;family management;feasibility testing;Feedback;Focus Groups;Foundations;Future;General Hospitals;Goals;Health;Health care facility;health disparity;health equity promotion;Healthcare;Healthcare Systems;hospital readmission;Hospitalization;Hospitals;Hybrids;improved;Individual;intergenerational;Intervention;intervention refinement;Interview;Knowledge;Leadership;Long-Term Care;Massachusetts;Measures;Medical;medical schools;Medicare/Medicaid;member;Mental Depression;Mentorship;Methods;Mission;Modeling;Modification;multidisciplinary;multiple chronic conditions;novel;Nursing Homes;nursing skill;older adult;older patient;Outcome;Outcome Measure;Participant;Patient Care;patient oriented;Patients;Persons;Pilot Projects;pilot test;Population;Program Evaluation;promote resilience;Protocols documentation;psychologic;psychological distress;psychological outcomes;Psychological Stress;psychological symptom;psychosocial;Questionnaires;Randomized;Randomized, Controlled Trials;readmission rates;Recovery;Rehabilitation therapy;Research;Research Design;Research Personnel;Research Support;Resources;Risk;Risk Reduction;skill acquisition;Skilled Nursing Facilities;skills;socioeconomic disadvantage;socioeconomics;Statistical Data Interpretation;Stress;stressor;Structure;Surveys;System;telehealth;Testing;theories;therapy design;therapy development;Training;treatment as usual;United States National Institutes of Health;Work

PROJECT_TITLE: Building Resilience In SKilled nursing facilities (BRISK): Development and Pilot Testing of a Dyadic Intervention for Psychological Distress in Post-Acute Skilled Nursing Care

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Rural Health

PI_NAMEs: WILLIAMS, VALERIE  (contact)

PROJECT_TERMS: Address;Affect;Applications Grants;Arkansas;broadening participation research;career;career development;certificate program;Certification;Cities;Clinical;clinical development;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;college;Communities;Community of Practice;community partners;Competence;COVID-19;design;Development;Distant;E-learning;Education;Educational Curriculum;Educational workshop;Effectiveness;Enrollment;Ethics;evidence base;experience;Faculty;Female;Fostering;Funding;Goals;graduate student;Growth;Health;Hour;Individual;Infrastructure;Institution;Interdisciplinary Study;interest;Investments;K-Series Research Career Programs;Knowledge;Leadership;Learning;Location;Master of Science;Medical;member;Mentors;Mentorship;minority investigator;Mission;Nevada;novel;Oklahoma;online resource;pandemic disruption;Participant;peer coaching;Phase;Population;post-COVID-19;Productivity;Professional Organizations;professional students;Program Development;programs;Protocols documentation;psychologic;Research;research and development;Research Personnel;Research Project Grants;research to practice;Research Training;Resources;Rural;Rural Community;Schedule;Scientist;Services;Site;skill acquisition;skills;Societies;success;summer research;summer student;Teacher Professional Development;Training;Training and Education;training opportunity;Training Programs;Translating;Translational Research;translational research program;Travel;tribal community;Tribes;undergraduate research experience;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Update;web portal;Wyoming

PROJECT_TITLE: Professional Development