ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Genetics;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Mild traumatic brain injury is extremely common among adolescents, who suffer disproportionately from prolonged concussion symptoms – a condition for which no biologic test exists. Emerging evidence suggests non-coding RNA released into saliva by neurons and glia, may provide a biologic window into the brain’s repair response. This study will measure longitudinal brain-related RNA levels in the saliva of adolescents with mild traumatic brain injury to: 1) validate an innovative method that helps clinicians predict the duration and character of concussion symptoms; and 2) define a biologic signature that aids assessment of concussion recovery for return-to-play and return-to-learn decisions.

PI_NAMEs: HICKS, STEVEN DANIEL (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 21 year old;Acute;Adolescent;Age;Algorithms;Athletic;Berlin;Biological;Biological Testing;Brain;Brain Concussion;brain repair;Caring;Centers for Disease Control and Prevention (U.S.);Cerebrospinal Fluid;Child;Childhood;Childhood Injury;Chronic;Clinical;clinical application;Clinical assessments;Clinical Management;clinical predictors;cohort;Cohort Studies;Collaborations;concussive symptom;Consensus;Emergency Medicine;Enrollment;epitranscriptomics;Equipment and supply inventories;exosome;experience;Factor Analysis;Family;feature selection;Follow-Up Studies;Genetic Transcription;Goals;Guidelines;Hour;Injury;innovation;Learning;Measures;Mediating;Medical;Methods;MicroRNAs;mild traumatic brain injury;Modeling;Molecular;Molecular Biology;Molecular Profiling;Multicenter Studies;multidisciplinary;multiplex assay;neurobehavioral;Neuroglia;Neurology;Neurons;Olfactory Nerve;Oropharyngeal;Outcome;Participant;Patient Self-Report;patient subsets;Patients;pediatric patients;Pediatrics;Performance;Peripheral;personalized management;Pharmacological Treatment;Phenotype;Physicians;Pilot Projects;Play;Post-Concussion Syndrome;prediction algorithm;predictive modeling;predictive tools;Prognosis;protein expression;Psychiatric Social Work;psychologic;Psychological Factors;Psychology;Publishing;Reaction Time;Recommendation;Recovery;repaired;Reporting;Research;Research Personnel;response;return to sport;Risk;RNA;Saliva;saliva sample;Schools;Sensitivity and Specificity;Serum;Severities;social;social factors;Standardization;success;Surveys;Symptoms;TBI treatment;Techniques;Technology;Testing;Time;tool;Training;Untranslated RNA;Validation;World Health Organization

PROJECT_TITLE: Poly-omic predictors of symptom duration and recovery for adolescent concussion

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative There are too few under-represented minorities, people with disabilities, and persons from rural and inner-city communities who are pursuing careers as researchers who will develop new treatments for cardiovascular disease, the most common cause of morbidity and mortality both internationally and within the United States. Over the last 15 years, Virginia Commonwealth University’s Pauley Heart Center, has created a high-quality research environment with federally funded, multi-disciplinary (involving collaborations among seven [7] institutional departments), translational (involving pursuit of fundamental discoveries that impact meaningful health outcomes) research projects conducive to training and mentoring students interested in a future related to cardiovascular care. We now propose to further expand this academic environment to partner with six Universities across Virginia in a shared goal to teach and engage a diverse range of students in learning to perform translational cardiovascular research.

PI_NAMEs: HUNDLEY, WILLIAM GREGORY (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Accounting;Address;Advisory Committees;African American;Alaska Native;American Indians;Area;Asian;atmospheric sciences;Award;Basic Science;Behavioral;Biocompatible Materials;Biomedical Research;Black race;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular health;Cardiovascular system;career;career development;Caring;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;cognitive ability;cohort;Collaborations;college;Communication;Communities;community college;Computers;Data;design;Development;Diagnosis;Diagnostic;disability;disabled;Disabled Persons;Disadvantaged;disadvantaged background;disadvantaged student;Discipline;Disparity population;Doctor's Degree;Economics;Education;Education Projects;Educational Curriculum;Educational process of instructing;Engineering;Enrollment;Environment;Equipment;Ethics;ethnic minority;Ethnic Origin;Event;experience;Extramural Activities;Faculty;Family;Funding;Future;gender diverse;Goals;Graduate Education;graduate school;Grant;Health;health disparity;Hearing;Heart;Hispanic;Independent Living;Individual;inner city;innovation;Institution;Interdisciplinary Study;interest;International;Latino;Learning;Location;Manuscripts;medical schools;Mentors;Minority;Minority Groups;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Native Americans;Oral;Outcome;Peer Review;Performance;Persons;Phenotype;Physicians;posters;prevent;profession allied to medicine;Program Development;programs;Prospective cohort;Public Health;Publications;Race;racial diversity;racial minority;racial population;Recommendation;recruit;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;research study;Research Training;Resources;Risk Factors;Rural Population;Science;scientific atmosphere;Scientist;Seasons;Self Care;Series;social;student mentoring;student participation;Students;summer research;support network;symposium;System;Testing;Training;Translational Research;translational scientist;undergraduate education;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Virginia;Vision;Writing

PROJECT_TITLE: Undergraduate Cardiovascular Research Program


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This project aims to develop and institutionalize the Malaysian Implementation Science Training (MIST) – the first training on HIV and implementation science that incorporates human rights training in Malaysia. The proposed research is relevant to the HIV research priorities identified by NIH as it provides advanced training to the next generation of researchers and public health professionals in Malaysia to have the skills necessary to address health disparities and to improve HIV care continuum among key populations.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact);KAMARULZAMAN, ADEEBA

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;AIDS prevention;antiretroviral therapy;Asia;Caring;Certification;Collaborations;Communities;Development;Disease;Educational Curriculum;Educational Status;Epidemic;Evidence based intervention;Faculty;female sex worker;Government;health disparity;HIV;Human immunodeficiency virus test;Human Rights;Hybrids;implementation research;implementation science;Injecting drug user;Institutionalization;international partnership;Investments;Knowledge;Malaysia;Malaysian;Medical;medical schools;men who have sex with men;Modeling;Needle-Exchange Programs;Needles;next generation;Outcome;Phase;Politics;Population;Populations at Risk;pre-exposure prophylaxis;Prisoner;Public Health;public health research;Religion;Research;research faculty;Research Personnel;Resources;Risk;scale up;skills;social culture;Students;Teacher Professional Development;Training;Training Programs;transgender;Universities;Volatilization

PROJECT_TITLE: Malaysian Implementation Science Training (MIST) Program in HIV


ADMINISTERING_IC: DE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Head and neck squamous cell carcinoma (HNSCC) is a major cause of cancer-related mortality and long-term disability. Most patients have abysmal outcomes, with five-year survival rates of less than 40%. Recently, single cell analysis of HNSCC tumors revealed a new transcriptional pathway dubbed the hybrid epithelial/mesenchymal (HEM) program that is a critical driver of invasion and metastasis in this cancer. The importance of this pathway is highlighted by the fact that the presence of the HEM signature in tumors is more predictive of treatment outcome than any other commonly used pathologic or demographic factor. Can this pathway be targeted to improve treatment of patients with HNSCC? The main driver of HEM appears to be a transcription factor called Snail2. Since it is difficult to develop drugs to transcription factors, we propose to map the genes regulated by Snail2 and determine which of these drive the metastasis and invasion phenotypes observed in HEM cells. We also propose to learn which other transcription factors regulate HEM in concert with Snail2 and to map their target genes. Accomplishing these goals will identify opportunities for rational drug design and targeted therapeutics against HNSCC.

PI_NAMEs: PURAM, SIDHARTH VENKATA (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 3-Dimensional;attributable mortality;Automobile Driving;Binding Sites;Biological Assay;Biological Process;Biotin;Cancer Etiology;Cancer Model;Carcinogens;Catalogs;Cell Fraction;Cell Line;Cells;Chimeric Proteins;ChIP-seq;Chromosome Mapping;Complement;CRISPR interference;Data;Demographic Factors;Development;Disease;Dissection;DNA;domain mapping;Drug Design;Drug Targeting;epithelial to mesenchymal transition;Epithelium;Etiology;experimental study;Family member;Gene Expression Profile;Gene Targeting;Genes;Genetic;Genetic Complementation Test;Genetic Epistasis;Genetic Transcription;Genome;Genomic approach;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;HPV negative;Hybrids;Immunoprecipitation;improved;In Vitro;in vivo;in vivo Model;Individual;interest;Invaded;knock-down;Knowledge;Label;lead candidate;Learning;Ligase;Literature;Long term disability;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mesenchymal;Molecular Target;mortality;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Oncogenes;Oncogenic;Organoids;Outcome;overexpression;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;Play;Prediction of Response to Therapy;Process;programs;protein complex;protein protein interaction;Proteins;rational design;Repression;Resolution;Role;Scheme;single cell analysis;single cell ATAC-seq;small molecule;Smoking;Snails;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome sequencing;Treatment Failure;Treatment outcome;tumor;Tumor Cell Invasion;tumor progression;Tumor Promotion;Validation

PROJECT_TITLE: Dissecting hybrid epithelial-mesenchymal states in head and neck cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The frog Xenopus tropicalis can fully regenerate the spinal cord following injury, a capability that is lost as the tadpole undergoes metamorphosis. Our project centers on defining the transcriptional regulatory networks that allow neural progenitor cells to regenerate a functional spinal cord after injury, how these contrast with embryonic patterning mechanisms, and the changes in neural progenitors that lead to regeneration failure in the post-metamorphic frog.

PI_NAMEs: WILLS, ANDREA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Articulation;ATAC-seq;Atlases;Biological Metamorphosis;Biological Models;Cell Cycle;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;Competence;Complex;Cues;Data;DNA;Dorsal;Embryo;Embryonic Development;Engraftment;Epigenetic Process;Failure;Functional Regeneration;functional restoration;Gene Targeting;Genetic Transcription;Goals;healing;Human;improved;Injury;loss of function;Modeling;Molecular;Motor Neurons;Natural regeneration;Nerve Regeneration;nerve stem cell;neural;Neural tube;Neurons;novel;novel therapeutic intervention;Outcome;Patients;Pattern;PBX3 gene;Positioning Attribute;programs;Proliferating;Property;Proteins;Rana;regeneration model;regenerative;regenerative biology;Regenerative Medicine;Regulation;Resolution;response to injury;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;spinal cord regeneration;stem cell population;stem cells;Structure;success;System;Systems Analysis;Tadpoles;targeted imaging;targeted treatment;Testing;Therapeutic;transcription factor;transcription regulatory network;Work;Xenopus

PROJECT_TITLE: Transcriptional regulatory mechanisms of vertebrate regeneration

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Mental Health;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Dysregulated immunity is a hallmark of many neurological disorders including delirium and dementia. Delirium superimposed on dementia remains a poorly understood, life threatening, complication that impacts millions of Americans that require common surgical interventions, such as orthopedic surgery. The proposed research will address this serious public health concern by clarifying molecular and cellular mechanisms that drive the onset of delirium.

PI_NAMEs: TERRANDO, NICCOLO  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Abeta clearance;abeta deposition;Acute;advanced dementia;Affect;Aging;aging population;Alzheimer's Disease;American;Amyloid;Amyloid beta-Protein;Animal Model;Atlases;Attention;Attenuated;Behavior;behavioral outcome;Binding;Blood;Blood - brain barrier anatomy;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain parenchyma;Brain region;Candidate Disease Gene;Cells;Central Nervous System Diseases;Coagulation Process;cognitive function;Complication;cytokine;Data;Death Rate;defined contribution;Delirium;Dementia;Deposition;efficacy evaluation;efficacy testing;Elderly;Electric Stimulation;Fibrin;Fibrinogen;fracture risk;Functional impairment;Gene Expression Profile;genome-wide;glial activation;Goals;Growth;Hand;Health Care Costs;Heterogeneity;Hippocampus;Human;Immune;immune cell infiltrate;Immune signaling;Immunity;Immunotherapy;Impaired cognition;Impairment;inattention;Individual;Induced Neurons;Inflammation Mediators;Innate Immune System;innovation;ITGAM gene;ITGB2 gene;Knowledge;Laboratories;Life;Maps;Memory Loss;Microglia;minimally invasive;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;Mus;mutant;Nerve Degeneration;Nervous System Disorder;neurocognitive disorder;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurological outcome;Neurons;neuropathology;neuroprotection;neurotoxic;neurovascular unit;novel;older adult;Operative Surgical Procedures;organ on a chip;Orthopedic Surgery;Oxidative Stress;Pathway Analysis;Pathway interactions;Patients;Peripheral;Persons;postoperative delirium;Postoperative Period;prevent;Prognosis;progressive neurodegeneration;Projections and Predictions;Public Health;Quality of life;Reaction Time;receptor;repaired;Research;response;Risk;Risk Factors;Role;Sampling;SARS-CoV-2 infection;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stressor;synergism;Techniques;Technology;Testing;Tibial Fractures;transcriptomics;Transgenic Organisms;Trauma;United States;Up-Regulation;vagus nerve stimulation;Vascular Diseases

PROJECT_TITLE: Microglia-Amyloid interactions in delirium superimposed on dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Just by using oxygen to generate energy, cells sustain daily oxidative DNA damage. This oxidative DNA damage is especially dangerous at replication forks, where the damage must be repaired before replication makes the oxidative mutations permanent. EEPD1 mediates a unique pathway for the cell to repair this damage that brain cancers subvert for their survival.

PI_NAMEs: HROMAS, ROBERT A (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Affect;Aging;Amino Acids;base;Base Excision Repairs;Brain;Brain Injuries;BRCA1 gene;Catalytic Domain;Cell Aging;Cell Death;Cell Line;Cell Survival;Cells;chelation;Dangerousness;Development;differential expression;dimer;Dimerization;Divalent Cations;DNA;DNA Binding;DNA Damage;DNA lesion;DNA Repair Pathway;DNA replication fork;Electrostatics;endonuclease;Environment;Enzymes;Eukaryota;Excision;Excision Repair;EXO1 gene;Exposure to;Face;Genome;Genome Stability;Genomic Instability;Glioblastoma;Glioma;homologous recombination;Human;Hypoxia;in vitro Assay;in vivo;inhibitor;insight;Leisures;Length;Lesion;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Minority;monomer;Mutation;Neoplastic Cell Transformation;new therapeutic target;nuclease;Nucleotides;Organ;Organism;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Oxygen;Pathway interactions;Physiological;Play;Proteins;public health relevance;rational design;recombinational repair;recruit;repaired;replication stress;Reporting;Resected;Role;Site;Stress;stressor;Structure;Structure-Activity Relationship;Testing;tumor;X-Ray Crystallography

PROJECT_TITLE: EEPD1 Repair of Stressed Replication Forks

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This project proposes to develop a paper-based blood test through the multiplexed analysis of five colorectal cancer biomarkers, which are expected to provide accurate early detection when combined with our signal amplification strategy. The proposed research project is relevant to public health because it seeks to develop a more sensitive, low-cost, and minimally invasive blood test to improve colorectal cancer screening rates in minorities, uninsured and low-income patients. Upon completion, this project will provide community health centers with unique preventive and diagnostic capability that will enable them to expand their reach to all eligible patients.

PI_NAMEs: BADU-TAWIAH, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: 3-Dimensional;accurate diagnostics;Acids;Address;African American;Air;Antibodies;biobank;Biological Markers;biomarker selection;Blood specimen;Blood Tests;CA-125 Antigen;cancer biomarkers;cancer care;Cancer Control;cancer health disparity;Carcinoma;care systems;catalyst;Chemicals;Clinical;Collection;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer screening;cost;Cryopreservation;Death Rate;design;Detection;detection platform;Development;Devices;Diagnosis;Diagnostic Procedure;diagnostic strategy;diagnostic value;Disease;Disparity;Early Diagnosis;Eligibility Determination;Ensure;Enzymes;Exclusion;experience;Fecal occult blood;Feces;Fingers;Geographic Locations;Goals;Guaiac;Guidelines;Heme;Hemoglobin;Hemorrhage;Hispanic Populations;Home;Hygiene;Immunoassay;improved;Incidence;Income;innovation;interest;Intestines;Investigation;Life;Low income;Low Income Population;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Medical;method development;Methods;Microfluidic Microchips;minimally invasive;Minority;models and simulation;Modernization;Monitor;mortality;multiplex detection;Neighborhood Health Center;Neoplasms;novel;novel strategies;operation;Outcome;outreach;outreach program;Paper;Pathology;Patients;Performance;Persons;photosystem;Plasma;Play;point of care testing;polymerization;Polymers;Population;portability;Predisposition;Preventive;Preventive service;programs;protein biomarkers;Proteins;prototype;Public Health;Race;Reaction;Recommendation;regenerative;Reporting;Research;Research Project Grants;Role;Sampling;screening;Screening procedure;screening program;self testing;Sensitivity and Specificity;Serum;Signal Transduction;Specific qualifier value;Specificity;Statistical Algorithm;survival outcome;System;Techniques;Technology;Testing;Time;Tumor Antigens;underserved community;Underserved Population;Uninsured;United States;Vulnerable Populations;Whole Blood

PROJECT_TITLE: Multiplexed Paper-Based Blood Test for Early-Stage Colorectal Cancer Screening


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Obesity and NASH have reached epidemic proportions. We will exploit our recent discovery of a key role for the enzyme caspase-6 by developing and testing novel potent and selective inhibitors of this enzyme..

PI_NAMEs: ARKIN, MICHELLE ;RENSLO, ADAM R;SALTIEL, ALAN R. (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Affect;Affinity;analog;Animal Model;Apoptosis;Apoptotic;Attenuated;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Availability;Biological Markers;biomarker identification;Biopsy Specimen;CASP3 gene;CASP6 gene;Caspase;Caspase Inhibitor;Cell Culture Techniques;Cell model;Cells;Cessation of life;Chemicals;Chronic;Clinical;clinical candidate;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Cysteine;cytochrome c;Data;design;Development;Diet;Drug Kinetics;Enzyme Inhibitor Drugs;Enzyme Precursors;Enzymes;Epidemic;experience;Fibrosis;Funding;Future;Genomics;Half-Life;Hepatic;Hepatocyte;High Pressure Liquid Chromatography;Human;improved;In Vitro;in vivo;inhibitor;insight;knock-down;Knock-out;knockout animal;Laboratories;Lead;lead series;Ligands;Liver;Liver Fibrosis;liver injury;Measures;Metformin;Mitochondria;Modeling;Monitor;mouse model;Mus;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phenotype;Phosphorylation;Play;preclinical development;Process;Property;Proteins;Proteomics;Readiness;Repression;Roentgen Rays;Role;Safety;Sampling;sensor;Series;Serum;Small Interfering RNA;Specificity;Structure;targeted biomarker;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Work

PROJECT_TITLE: Development of caspase-6 inhibitors for treatment of NASH

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Inclusive Excellence Training Program in the Systems Biology of Cardiovascular Inflammation is a new training program at the University of Minnesota. This program fills a major void at our institution by focusing emphasis on the highly clinically relevant problem of inflammation in cardiovascular biology, obesity, diabetes and metabolism with study focus from gene to whole organism. This program will train the next generation of biomedical researchers by leveraging outstanding faculty with successful mentoring history and new core facilities for a stellar training program for our trainees.

PI_NAMEs: METZGER, JOSEPH MARK (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Cardiovascular system;Inflammation;Systems Biology;Training Programs


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE Very little is known about the factors that regulate antiviral immune responses in the oral cavity, a prime site for viral infection and dissemination to other tissues. In this proposal, we will determine how viral-bacterial and epithelial interactions occurring at the oral mucosal barrier impact the development of antiviral immunity and, in turn modulate host susceptibility to oral viral infections.

PI_NAMEs: BAGAITKAR, JUHI  (contact);LAMONT, RICHARD J

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 2019-nCoV;Address;Agonist;airway epithelium;Anatomy;Anti-viral resistance;Anti-viral Response;antimicrobial;antiviral drug development;antiviral immunity;autocrine;Bacterial Infections;Cells;Chronic;Complex;cytokine;Data;desensitization;Distant;dysbiosis;Epithelial Cells;Epithelium;gastrointestinal;Gene Expression;Genes;genetic signature;gingipain;Gingiva;Goals;Immune;Immune response;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Interferon Receptor;Interferon Suppression;Interferon Type I;Interferon Type II;Interferons;IRF1 gene;Localized Disease;Location;Mediating;Microbe;mouse model;Nature;neutrophil;NF-kappa B;novel;Oncogenic Viruses;Oral;Oral cavity;oral cavity epithelium;Oral mucous membrane structure;oral tissue;Oropharyngeal;Outcome;paracrine;Paralysed;Pathogenicity;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;Play;Porphyromonas gingivalis;Predisposition;Production;promoter;Reactive Oxygen Species;receptor;receptor binding;recruit;Refractory;Regulation;reproductive;respiratory;respiratory virus;response;Role;Signal Transduction;Site;STAT1 gene;Surface;Systemic disease;Testing;Tissues;transcription factor;Viral;viral resistance;Virulence Factors;Virus;Virus Diseases

PROJECT_TITLE: Regulation and Manipulation of Oral Type III Interferon Responses by Porphyromonas gingivalis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Machine Learning and Artificial Intelligence;Telehealth

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE As our population ages, and the need for dermatologic care continues to grow, there is an urgent need for a user-friendly tool for older patients to collect photographs, report symptoms and monitor their skin disease from home. We propose to use our novel, older adult-friendly, automated text virtual assistant – Dermatology of OldeR Adults (DORA) – to develop a longitudinal diverse image library of common skin diseases and describe the progression of common skin diseases affecting older adults. We will compare the information collected virtually through DORA to in-person clinical assessments at 6 and 12 months to inform the long-term use of this novel tool to monitor skin disease in older adults from home.

PI_NAMEs: LINOS, ELENI  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Age;aged;American;automated text message;Biological Markers;Caregivers;Caring;Childhood;Chronic;Clinic Visits;Clinical;Clinical assessments;Clinical Course of Disease;Clinical Research;Collection;COVID-19 pandemic;Data;Dermatologic;Dermatologist;Dermatology;design;Diagnosis;digital monitoring;digital tool;Disease;Disease Progression;Elderly;Epidemiology;Exanthema;experience;fall risk;Flare;Frail Elderly;Friends;Future;Geriatrics;healing;health care disparity;health care settings;Home;human old age (65+);human very old age (85+);Image;image archival system;improved;Incidence;Inflammatory;innovation;intelligent personal assistant;Interview;Learning;literacy;Longitudinal cohort;Machine Learning;Measures;mHealth;Modeling;Mole the mammal;Monitor;multidisciplinary;Natural History;novel;older adult;older patient;Older Population;Participant;Patients;Pattern;Persons;Physicians;Pilot Projects;Population;Positioning Attribute;Primary Care;prospective;Quality of life;Recommendation;Reporting;Research Personnel;retention rate;Sampling;satisfaction;serial imaging;Severity of illness;Skin;skin color;skin disorder;Structure;Symptoms;Technology;teledermatology;Telemedicine;Text Messaging;Time;tool;Training;treatment response;Triage;Trust;Ulcer;United States;user-friendly;virtual;Visit;Visual

PROJECT_TITLE: Novel digital tools for home-based monitoring of skin disease

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC(10)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Maternal Health;Nutrition;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE  Maternal blood vessels undergo dramatic adaptations to decrease blood pressure and increase uteroplacental perfusion to meet the metabolic demands of the fetus. The proposed studies will help define the role of environmental exposure to perfluorooctane sulfonate (PFOS) in blunting vascular relaxation, increasing blood pressure, and decreasing uteroplacental perfusion and nutrient transport to the fetus during pregnancy. These results will contribute substantively to a mechanism-based understanding of PFOS's role in pregnancy complications and alert environmental agencies to devise policies to curtail PFOS exposure to reproductive- age women.

PI_NAMEs: KUMAR, SATHISH  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;Affect;Age;Amino Acids;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Animals;Area;Arteries;bioaccumulation;Biological Monitoring;Blood flow;Blood Pressure;blood pressure elevation;Blood Vessels;Cardiovascular Physiology;Cell Separation;Cells;channel blockers;Chemicals;clinical care;consumer product;Developed Countries;Development;Diameter;Disease;Doppler Ultrasound;Economic Burden;Endothelial Cells;endothelial dysfunction;Endothelium;environmental agent;Environmental Exposure;Epoprostenol;Equilibrium;Essential Fatty Acids;Etiology;Exhibits;Exposure to;Failure;Family;fatty acid transport;fetal;Fetal Growth;Fetal Growth Retardation;Fetal health;Fetus;Functional disorder;Future;Glucose;Growth;Health;hemodynamics;high risk;Human;human tissue;Hypertension;Impaired cognition;Impairment;In Vitro;in vivo;Intervention;knock-down;Length;Life;Measures;Mediating;Membrane Potentials;Mesentery;Metabolic;Metabolic syndrome;microCT;Modeling;Molecular Analysis;mother nutrition;Mothers;Myography;National Institute of Environmental Health Sciences;Nature;Neurologic;Newborn Infant;Nitrates;Nitrites;Nutrient;offspring;Organ;Outcome;overexpression;Pathway interactions;perfluorooctane sulfonate;Perfusion;Perinatal Care;perinatal morbidity;Pilot Projects;Placenta;Policies;Poly-fluoroalkyl substances;Potassium Channel;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Process;Production;programs;Public Health;Radioactive Tracers;Rattus;Relaxation;reproductive;Research Priority;Resistance;Risk;Risk Assessment;Role;sex;Signal Pathway;Signal Transduction;Spiral Artery of the Endometrium;Structure of umbilical artery;System;Systemic blood pressure;Telemetry;Testing;Time;Tissues;Toxic effect;translational study;trophoblast;Uterus;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;Vasodilation;Water;Woman;Work

PROJECT_TITLE: Per- and poly-fluoroalkyl substances (PFAS) in pregnancy vascular and placental dysfunction

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Chylomicrons are large lipoproteins that consist mainly of fats and cholesterol. They transport dietary fats from the intestines to other parts of the body, and have been widely considered to not promote the formation of fatty plaques in arteries. The overall goals of this project are to understand the biological consequences of chylomicron uptake across the thin endothelial layer that lines blood vessels, and how chylomicrons affect arterial biology.

PI_NAMEs: GOLDBERG, IRA J (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Activins;Affect;Albumins;apolipoprotein B-48;Apolipoproteins B;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;Binding Sites;Biological;Biology;Blood Vessels;Body part;Cardiovascular Diseases;CD36 Antigens;Cells;Cellular biology;Cholesterol;Cholesterol Esters;Chylomicrons;Data;Deposition;Dietary Fats;endothelial cell scavenger receptor;Endothelial Cells;Endothelium;Event;extracellular vesicles;Fatty acid glycerol esters;Filtration;Gene Expression;Gene Modified;Goals;Heart;Hypertriglyceridemia;impression;In Vitro;in vivo;Inflammation;Intestines;knock-down;Label;LDL Cholesterol Lipoproteins;Length;Leukocytes;Ligand Binding;Link;Lipids;lipoprotein lipase;Lipoproteins;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Lysosomes;Macrophage;Mediating;Movement;Mus;N-terminal;Nonesterified Fatty Acids;novel;novel strategies;overexpression;Pathway interactions;Peptide Fragments;Phenotype;Phosphotransferases;prevent;Process;Production;Proteins;receptor;Reporting;Research Personnel;RNA;Role;Side;Site;Source;Specificity;SR-BI receptor;Surface;Testing;Thinness;Tissues;transcytosis;Travel;Triglycerides;uptake;Vascular Diseases;Vascular Endothelium;vesicular release;Work

PROJECT_TITLE: Chylomicrons and endothelial biology

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dietary Supplements;Genetics;Natural Products;Nutrition;Prevention

ORG_CITY: GREENSBORO

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: Projective narrative The rising super crop tef has a great potential as nutritious and healthy grains, but there has been limited knowledge available on this crop due to lack of investment in its research and limited genome information. This proposal aims to identify bioactive chemicals from tef grains and study their role in boosting the antioxidant pathway towards mitigating ROS-induced inflammatory diseases such as CVD, type II diabetes and cancer. We also aim to identify the molecular genetic mechanisms regulating variation in antioxidant activity in tef grains that can be used to improve tef or introduced into other major crops such as corn via molecular breeding.

PI_NAMEs: OSENA, AYALEW LIGABA (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acids;Adult;Affect;Africa;Age;Alternative Medicine;Anabolism;Anthocyanins;Antioxidants;Australia;Barley;Biochemical;Biological Assay;Blood Glucose;Bread;Cardiovascular Diseases;Celiac Disease;Cell model;Cells;Cereals;Chemicals;China;Colon;combat;Consumption;Country;Cytoprotection;Data;Diabetes Mellitus;Diet;Dietary Fiber;diphenyl;Disease;DNA Shuffling;Environment;Eragrostis;Eritrea;Essential Amino Acids;Ethiopia;Female;Flavonoids;Food;food security;Funding;Genes;Genetic;Genetic Markers;Genetic Variation;Genome;Genotype;Glutamate-Cysteine Ligase;Glutathione;Glutathione Reductase;Gluten;Grain;Health;Health Benefit;heme oxygenase-1;Histidine;Horns;human disease;immunoreaction;improved;India;Inflammatory;Intake;Investments;Knowledge;Laboratories;Letters;Linoleic Acids;Lipid Peroxidation;Luciferases;Lysine;macromineral;male;Malignant Neoplasms;Mammalian Cell;Membrane Lipids;Methionine;Millet;Minerals;Minority Groups;Modeling;Molecular Genetics;monocyte;National Research Council;Non-Insulin-Dependent Diabetes Mellitus;novel;nuclear factor-erythroid 2;Nutrient;Nutritional;Oxidative Stress;Oxidative Stress Induction;Oxidoreductase;Pathogenicity;Pathway interactions;Persons;Phenols;Physiological;Phytochemical;Play;polyphenol;Polyunsaturated Fatty Acids;Population;prevent;Production;Property;Quinones;Reactive Oxygen Species;Recommendation;Reporter Genes;Research;Resistance;response;Risk Factors;Role;Rye cereal;Signal Transduction;South Africa;stable cell line;Starch;student training;Sulfonic Acids;Techniques;Testing;Trace Elements;trait;transcriptome;underrepresented minority student;United States;United States National Institutes of Health;Variant;Water-Soluble Vitamin;Weight maintenance regimen;Wheat

PROJECT_TITLE: Identification of bioactive compounds from tef (Eragrostis tef) seed extracts for antioxidant properties.


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Medulloblastoma is the most common malignant pediatric brain tumor, with deaths occurring due to metastatic spread of primary tumor to the leptomeningeal membranes that cover the brain and spinal cord. We present data that these metastases actually arise through active hematogenous dissemination rather than via passive spread through the CSF, as was presumed. We outline aims to determine the role of hematogenous dissemination across MB subgroups; determine the preclinical utility of circulating tumors cellsas a biomarker for metastasis; and to clarify roles and therapies for CCL2 and CCR2 in metastases.

PI_NAMEs: GARZIA, LIVIA ;TAYLOR, MICHAEL D.;WEISS, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Antibodies;Attenuated;Binding;Biological Markers;biomarker development;biomarker identification;Blocking Antibodies;Blood;Blood Circulation;Brain;Brain Neoplasms;Cancer Etiology;Carcinoma;Cause of Death;CCL2 gene;Cells;Cellular biology;Central Nervous System;Cerebrospinal Fluid;Cessation of life;chemokine;chemotherapy;Child;Childhood;childhood cancer mortality;Childhood Malignant Brain Tumor;Circulation;cognitive disability;Cytotoxic Chemotherapy;Data;Development;Diagnosis;disability;Disease;Disease Progression;Distal;economic cost;efficacy evaluation;Excision;experience;experimental study;FDA approved;Gene Modified;Genes;Genetic;Hematogenous;Hematogenous Spread;Homing;Human;Image;implantation;improved;in vivo;Individual;Inflammatory;knock-down;Left;Leptomeninges;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Membrane;Metastatic/Recurrent;Modeling;monocyte chemoattractant protein 1 receptor;Morbidity - disease rate;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Nervous System;Nonmetastatic;novel diagnostics;novel strategies;novel therapeutics;Organ;overexpression;paracrine;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;physically handicapped;Play;pre-clinical;prevent;Prevention;Primary Neoplasm;prophylactic;Publications;Radiation;Recurrence;Role;Series;SHH gene;social;Solid;Solid Neoplasm;Source;Spinal Cord;Subgroup;Surface;Survival Rate;Survivors;targeted agent;targeted treatment;Techniques;therapeutic target;therapy development;tool;transcriptome;tumor;Xenograft procedure

PROJECT_TITLE: CCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Nanotechnology

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Periodontitis is one of the most prevalent inflammatory diseases in humans and harbors heterogeneous disease phenotypes. A biomarker analysis in stages of a new periodontal profile classification, which improved the homogeneity within each disease stage, identified that Type I interferon played a novel regulatory role in periodontitis. This translational research program will delineate the mechanism of Type I interferon in dampening excess innate and adaptive immune response involved in periodontitis and evaluate the effect of a nanoparticle-mediated sustained delivery system that activates and releases Type I IFN locally in periodontitis.

PI_NAMEs: ZHANG, SHAOPING  (contact)

PROJECT_TERMS: Abate;adaptive immune response;Address;Adult;Affect;Agonist;Alveolar Bone Loss;anakinra;Animals;Anti-Inflammatory Agents;Biological;Biological Assay;Biological Markers;bone loss;Bone Marrow;Bone Resorption;CD4 Positive T Lymphocytes;cell type;Cells;Classification;clay;Clinical;Clinical Research;clinically relevant;cohort;Communities;Complex;conditional knockout;Control Animal;Coronary heart disease;Cyclic GMP;cytokine;Cytokine Network Pathway;Data;Diabetes Mellitus;Disease;disease classification;disease phenotype;Disease Progression;Family member;Flow Cytometry;follow-up;Genes;Genetic Transcription;Gingiva;Gingival Crevicular Fluid;Goals;Health;Heterogeneity;Human;IFNAR1 gene;IFNAR2 gene;IL17 gene;improved;in vivo;Incidence;indexing;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interferon Type I;Interferon-beta;Interferons;Interleukin-6;Knock-out;Knockout Mice;Ligation;Ligature;Lipopolysaccharides;LoxP-flanked allele;Macrophage;Measurement;Measures;Mediating;Mediator;member;Microinjections;Modeling;monocyte;Mouth Diseases;Multiple Sclerosis;Mus;Myelogenous;nano;nanoparticle;Nature;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;osteoclastogenesis;Osteoclasts;Pathway interactions;patient subsets;Patients;Pattern;Periodontal Diseases;Periodontitis;Phenotype;Play;Population;precursor cell;Predisposition;Prevalence;Production;Proteomics;receptor;Research;Research Proposals;response;Role;Signal Transduction;Staging;Staging System;Stroke;System;Systemic disease;Testing;Therapeutic;Time;Tissues;tool;Tooth Loss;Tooth structure;translational research program;Validation;Viral Physiology;Wild Type Mouse

PROJECT_TITLE: Assessing the role of Type I Interferon (IFN-I) in Periodontal Disease


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE We have identified a mitochondrial signaling axis centered on MnSOD-K68 which, when its normal acetylation status is altered, disrupts cell metabolism, leading to aberrant-ROS levels, and a tumor permissive phenotype (Zhu et al, 2019). Interestingly, emerging data suggests that the disruption of mitochondrial metabolism, including aberrant ROS levels, is an increasingly accepted mechanism of oncogenicity due to an enrichment of stem-like cells. Thus, it is proposed that when MnSOD-Ac exists outside of its normal physiological context, it disrupts cellular and mitochondrial metabolism and promotes lineage plasticity properties (or tumor cell stemness), leading to an oncogenic permissive and TamR phenotype, and is a potential target for new therapies.

PI_NAMEs: GIUS, DAVID  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetylation;Adjuvant Therapy;Biological Markers;Biology;Breast Cancer Cell;breast malignancies;cancer cell;Cell Physiology;Cells;Cellular Metabolic Process;Chemicals;ChIP-seq;Cisplatin;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Data;Doxorubicin;Drug Metabolic Detoxication;Endocrine;Equilibrium;Estrogen receptor positive;Event;Exhibits;Exposure to;Fatty acid glycerol esters;Fulvestrant;Genes;high risk;hormone therapy;in vivo;knock-down;Knock-out;Lead;Link;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;MCF7 cell;Measurement;Measures;Mediating;Metabolic;Metabolism;mimetics;Mitochondria;mitochondrial metabolism;Modeling;monomer;mouse model;mutant;Nature;neoplastic cell;new therapeutic target;novel;Oncogenic;Pathway interactions;patient derived xenograft model;permissiveness;Peroxidases;Phenotype;Physiological;Post-Translational Protein Processing;prevent;programs;Property;public database;Publications;Reactive Oxygen Species;Recurrence;Reporter;Resistance;response;Risk;Selective Estrogen Receptor Modulators;Signal Transduction;Sirtuins;small hairpin RNA;SOD2 gene;Stains;stem;stem cell biomarkers;stem-like cell;stemness;Subgroup;Superoxides;Systemic Therapy;T47D;Tamoxifen;targeted treatment;Techniques;Testing;therapy resistant;Time;tissue culture;Tissue Microarray;transcriptome sequencing;tumor;Tumor Promoters;tumorigenesis;tumorigenic;Woman;Work;Xenograft Model

PROJECT_TITLE: MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: PATHOLOGY

PHR: Public Health Relevance Phagocytosis of apoptotic cells is fundamentally important for many biological processes, and defects in cell clearance have been linked to multiple inflammatory diseases. Similarly, mutations in solute carrier (Slc) family proteins have been linked to >100 human diseases. This proposal addresses the role of the Slc genes and proteins during the process of apoptotic cell clearance, in the context of inflammation models. Since SLCs are membrane proteins and have been shown to be drug targets, the results of this proposal could have significant therapeutic implications for diseases such as autoimmune diseases, lung inflammation, atherosclerosis, and acute kidney injury, where both the apoptotic cell clearance and SLC function have been previously linked.

PI_NAMEs: RAVICHANDRAN, KODI S (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;aerobic glycolysis;Amino Acids;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Atherosclerosis;Autoimmune Diseases;Binding;Biological Process;Biology;Carrier Proteins;cell age;Cell Communication;cell injury;Cell membrane;Cells;Cellular Membrane;Chronic;Communication;Communities;Defect;Dendritic Cells;Development;Digestion;Disease;Drug Targeting;Eating;Epithelial Cells;Evolution;Excision;Family;Family member;Fibroblasts;G-Protein-Coupled Receptors;Gene Family;Genes;glucose uptake;Human;human disease;Human Genome;Immune system;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Insecta;insight;Ions;Knowledge;Knowledge acquisition;Life;Ligands;Link;Macrophage;Mediating;member;Membrane Proteins;Modeling;Mus;Mutation;Nature;Nematoda;Organ;Organism;Pathologic;Phagocytes;Phagocytosis;Phase;Play;prevent;Process;Protein Family;Proteins;public health relevance;Pulmonary Inflammation;receptor;Regulation;Role;Series;Signal Transduction;solute;Testing;Therapeutic;Tissues;transcriptome sequencing;uptake;urea transporter;Work

PROJECT_TITLE: Solute carrier proteins in efferocytosis and inflammation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE The proposed project aims to further develop innovative, easy-to-follow protocols for cryopreserving Drosophila (fruit fly) embryos in labs and stock centers around the world. These protocols, which likely prevent the genetic drift common to live stock continuation, will be a highly useful tool for reliable and cost-effective long-term preservation of thousands of Drosophila stocks.

PI_NAMEs: BISCHOF, JOHN C (contact);HAYS, THOMAS S

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acceleration;Adoption;Adult;Animal Model;Benchmarking;Biomedical Research;Collaborations;Collection;Communities;cost;cost effective;cost estimate;Cost-Benefit Analysis;Costs and Benefits;cryobiology;cryogenics;Cryopreservation;Disasters;Drosophila genus;Drosophila melanogaster;Educational workshop;Embryo;embryo cryopreservation;Event;experience;Feedback;flexibility;fly;Freezing;Future;Genetic;Genetic Diseases;Genetic Drift;genetic resource;Goals;hatching;Human Resources;Indiana;Individual;innovation;instrument;Larva;Maintenance;Malignant Neoplasms;Methods;next generation sequencing;Outcome;Outcomes Research;Pathway interactions;Population;preservation;prevent;Prevention;Procedures;Protocols documentation;Reagent;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Rewarming;Risk;Services;Shipping;Source;Standardization;success;Temperature;Testing;Time;tool;Training;Work

PROJECT_TITLE: Resources for Drosophila embryo cryopreservation at lab and stock center scale


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative It is well established that most individuals with alcohol use disorder (AUD) can briefly quit drinking, but a significant challenge is to not relapse to excessive drinking following a period of abstinence. The TSRI-ARC renewal addresses key gaps in our understanding of AUD, in that it focuses on the less well-understood persisting heightened neurobiological stress responses and impaired cortical control that may drive drinking relapse. The overall goal of TSRI-ARC is to identify fundamental neurobiological mechanisms mediating AUD, and guide the translation of our basic research findings toward helping individuals recover from AUD.

PI_NAMEs: MASON, BARBARA J (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;Address;Advisory Committees;Alcohol consumption;alcohol effect;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Astrocytes;Attenuated;Basic Science;Behavior;Behavioral;biological adaptation to stress;Brain;career;career development;Cell Nucleus;cell type;Cells;Cellular Neurobiology;clinical application;Collaborations;Complex;Corticotropin-Releasing Hormone;craving;Data;Diagnosis;drinking;Dynorphins;Effectiveness;efficacy evaluation;environmental stressor;equity, diversity, and inclusion;Functional disorder;Funding;Future;gamma-Aminobutyric Acid;Glutamates;Goals;health disparity;Healthcare;Heavy Drinking;high school;Hospitalization;hypocretin;Impairment;Individual;Infrastructure;International;Internships;Intoxication;Laboratories;Lead;Leadership;Learning;Ligands;Medial;Mediating;meetings;Methods;Molecular;Molecular Target;Monitor;Motivation;multidisciplinary;Mus;negative affect;Negative Reinforcements;neural circuit;neurobiological mechanism;Neurobiology;Neuropeptides;Neuropharmacology;neurophysiology;neuroproteomics;neurotransmission;next generation;nociceptin;novel;Occupations;pandemic stressor;Persons;pharmacologic;post-doctoral training;Prefrontal Cortex;prevent;Prevention;programs;Public Health;Publications;recruit;Relapse;relapse risk;Research;Research Institute;Research Personnel;Resources;response;Role;Series;social media;Source;Stress;Structure;Synaptic Transmission;System;therapeutic development;Training;Translations;web site;Withdrawal;Work

PROJECT_TITLE: CNS Effects of Alcohol: Cellular Neurobiology


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

PROJECT_TERMS: Abstinence;Advisory Committees;alcohol effect;alcohol research;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;Animal Model;archived data;Attention;Behavioral;Biochemical;Biological Assay;Budgets;Cells;Cellular Neurobiology;Charge;Collaborations;Communities;Community Outreach;cost effective;Data;data archive;Dependence;Ensure;equity, diversity, and inclusion;Expenditure;experience;Faculty;Familiarity;Fostering;Funding;Future;Goals;Grant;Guidelines;health disparity;Health Personnel;Healthcare;Heavy Drinking;high risk;interest;Internships;Lead;Leadership;lecturer;Maps;Medial;meetings;Methods;Molecular;Monitor;neural circuit;Neurobiology;Neuroimmune;Neuropharmacology;neurophysiology;neuroproteomics;Neurosciences;next generation;operation;Outcome;outreach;Postdoctoral Fellow;posters;Preclinical Testing;Procedures;programs;Proteomics;Publications;Recommendation;Relapse;Research;Research Institute;Research Personnel;Resources;Review Committee;Role;Science;Scientist;Series;Services;social media;Standardization;Stress;success;Techniques;Underrepresented Minority;United States National Institutes of Health;vapor;web site;Youth

PROJECT_TITLE: Administrative Core


ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: This proposal addresses the compelling need for new tools to study the relationship between human health and the role of sialylation in viral infections. Enabling technology that overcomes current limitations in the field will be used to rapidly characterize and then quantify sialylated glycans on the microscale in order to evaluate the inhibition and binding induced by these molecules.

PI_NAMEs: HOLLAND, LISA A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Address;Affinity;analog;Area;Automation;Binding;Biochemical;Biological;Biological Assay;Biological Markers;biomaterial compatibility;Blood capillaries;burden of illness;Capillary Electrophoresis;Cell surface;Cells;Chemicals;Chromatography;cold temperature;combat;Complex;Complex Mixtures;Consumption;cost;Coupled;Coupling;Derivation procedure;Detection;Development;Discrimination;Disease;Economic Burden;Electrophoresis;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Exoglycosidases;Functional disorder;Gel;gel electrophoresis;glycosylation;Health;Hemagglutinin;Heterogeneity;high throughput screening;Hospitalization;Human;Immune system;improved;Infection;Influenza;inhibitor;innovation;insight;instrument;Intercept;ion mobility;ionization;Isomerism;Label;Lectin;Life Cycle Stages;Ligands;Lipids;Liquid Chromatography;Liquid substance;Mass Spectrum Analysis;Measurement;mechanical energy;Methods;miniaturize;NanoGel;nanopattern;Neuraminidase;Neuraminidase inhibitor;Oseltamivir;Pattern;Pharmaceutical Preparations;Physiological;Play;Polysaccharides;Post-Translational Protein Processing;Preparation;promote resilience;Proteins;Reaction;Reagent;receptor;receptor binding;Reference Standards;Regulation;Research;Research Personnel;Role;Sampling;screening;Screening procedure;Sensitivity and Specificity;Sialic Acids;sialylation;Signal Transduction;small molecule;Source;Specificity;Speed;Structure;tandem mass spectrometry;Techniques;Technology;Temperature;Therapeutic;therapeutic development;Time;tool;United States;uptake;vibration;Viral;viron;Virus;Virus Diseases;Virus Receptors;Virus Replication;Viscosity;voltage;Work;zanamivir

PROJECT_TITLE: Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Nanotechnology;Neurofibromatosis;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE  Vestibular schwannoma (VS) is a brain tumor that severely impairs one’s ability to hear and communicate. Surgical removal of VS through a craniotomy leads to significant morbidities including hearing loss, paralysis of the face and injury to critical parts of the brain. Using a combination of the state-of-the art tools, including cell and animal models of VS, genomic sequencing and nanotechnology, this proposed study identifies new biomarkers that could help surgeons identify which VS are aggressive, and develops nanoparticles that home to tumor cells to label areas of the tumor to make surgery more precise and safer for patients.

PI_NAMEs: REN, YIN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acoustic Neuroma;Adhesions;Advisory Committees;angiogenesis;Animal Model;Architecture;Area;Behavior;Benign;bilateral vestibular Schwannoma;Biological;Biological Markers;Biology;biomarker identification;Brain;Brain Injuries;Brain Neoplasms;Brain Stem;career;Cell Line;Cell model;cell motility;Cells;Central Nervous System;Cessation of life;Classification;Cochlea;Communication;Convection;Cranial Nerves;Craniotomy;Cues;Cystic Neoplasm;Data;deafness;Debility;design;Disabling;Disease;disease classification;Dissection;Educational workshop;Engineering;Excision;Extracellular Matrix;Face;Facial Injuries;Facial paralysis;FDA approved;Fluorescence Resonance Energy Transfer;Foundations;Future;Gelatinase A;Gelatinase B;gene function;genomic data;Genomics;Goals;Growth;Hearing;hearing impairment;high throughput screening;Home;Human;Impairment;improved;improved outcome;in vivo;Incidence;innovation;Intracranial Neoplasms;K-Series Research Career Programs;Label;Libraries;Matrix Metalloproteinases;Mentors;Mentorship;Metalloproteases;Methods;MMP14 gene;molecular marker;Morbidity - disease rate;mouse model;multidisciplinary;Mus;nanomaterials;nanoparticle;nanoparticle delivery;Nanotechnology;Nature;neoplastic cell;Nerve;Nervous System Neoplasms;Neurilemmoma;Neurofibromatosis 2;Neurologic;novel diagnostics;novel therapeutics;Ohio;Operative Surgical Procedures;Outcome;overexpression;Paralysed;Patient-Focused Outcomes;Patients;Pattern;Penetration;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Play;point of care;preservation;Principal Investigator;Prognostic Marker;Research;Risk;Role;safe patient;Scientist;Sensitivity and Specificity;Serum;skull base;Specificity;Surgeon;surgery outcome;Survival Rate;Syndrome;systems research;Testing;Therapeutic;Tissues;tool;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;Translational Research;tumor;tumor growth;Tumor Suppressor Genes;Tumor Tissue;Universities;Visual;Visualization;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Engineering protease biomarkers to guide surgical therapy for vestibular schwannoma and Neurofibromatosis Type 2

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

PI_NAMEs: ROBERTS, AMANDA J (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol effect;alcohol research;alcohol use disorder;career;Career Choice;career development;Cellular Neurobiology;Communities;community center;Dependence;design;Education;Educational workshop;empowerment;equity, diversity, and inclusion;Ethics;experience;Fostering;Goals;Grant;Health Disparities Research;health disparity;health disparity populations;high risk;high school;High School Student;innovation;Instagram;Internships;Knowledge;Laboratories;Leadership;Learning;lectures;Medicine;meetings;member;Mentors;Minority;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;neuropsychopharmacology;Neurosciences;Outcomes Research;outreach;Persons;Population;Population Programs;Postdoctoral Fellow;posters;Prejudice;Problem Solving;programs;public trust;Publications;Recommendation;recruit;Research;Research Institute;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;social media;STEM field;STEM research;Students;teacher;Training;undergraduate student;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;virtual;virtual internship;Work

PROJECT_TITLE: Dissemination Core - Roberts


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Nickel is a cancer-causing industrial metal that is abundantly released in the environment from combustion of fuels and during manufacture, processing and disposal of many metal products. This project will investigate how nickel produces DNA damage that leads to cancerous transformation of cells. A completion of the proposed studies will improve understanding of cancer risks resulting from human exposures to nickel.

PI_NAMEs: ZHITKOVICH, ANATOLY  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Affect;Alloys;Aneuploidy;Animal Experiments;animal tissue;Animals;Biochemical;Biological Assay;BRCA1 gene;cancer risk;Cancerous;carcinogenicity;Carcinogens;Cell Survival;cell transformation;Cells;Chemicals;Chromosomal Rearrangement;Chromosome abnormality;Chromosomes;Complex;cost;Cultured Cells;Defect;Dependence;design;dietary;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA Sequence Alteration;DNA-protein crosslink;Dose;Double Strand Break Repair;Environment;Environmental Pollutants;Environmental Pollution;Enzymes;Event;exposed human population;Exposure to;Fiber;Fossil Fuels;Genetic;Genetic Induction;Genetic Recombination;Genomics;genotoxicity;homologous recombination;Human;improved;Incineration;Individual;Industrialization;Inhalation;Ions;Ligation;Link;Lung;lung development;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;Measurement;Metals;Methodology;Microtubules;Mitotic spindle;Modeling;Molecular;Molecular Abnormality;Mutation;Nickel;Nonhomologous DNA End Joining;Nose;novel;novel marker;nuclease;Occupational Exposure;Oncogenic;pollutant;Population;prevent;Process;Production;recombinational repair;repaired;Repression;Risk Assessment;Role;Rotation;S phase;single molecule;Source;Stainless Steel;superfund site;Superhelical DNA;Testing;Time;Tumorigenicity;Type I DNA Topoisomerases;wasting;Work

PROJECT_TITLE: Nickel and toxic topoisomerase I products

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Humanized mouse models remain suboptimal in mounting a human immune response and lack key components of human mucosal immunity. To address these research gaps, we propose to construct and credential a novel model based on genetically engineered immunodeficient mice, which, when transplanted with human hematopoietic progenitor cells and human bronchial epithelial progenitor cells, will develop a broad range of human immune cell types and a human lung epithelium, thereby enabling the study of human mucosal immunity. Once credentialed, our model will facilitate a wide range translational immunology studies and testing of mucosal adjuvants, allergens, vaccines, and biologicals.

PI_NAMEs: PALUCKA, ANNA KAROLINA  (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Address;Adjuvant;airway epithelium;Allergens;Antibodies;antigen-specific T cells;Antigens;B-Cell Activation;B-Lymphocytes;Biological;Blood;Bone Marrow;Bronchi;bronchial epithelium;CD34 gene;Cell Communication;cell motility;Cell Physiology;cell regeneration;cell type;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Credentialing;cross reactivity;cytokine;Dendritic Cells;Development;Disease;Engraftment;Environment;enzyme linked immunospot assay;Epithelial Cells;epithelial stem cell;Epithelium;Extrinsic asthma;fetal;Fibroblasts;FLT3 gene;FluMist;Formulation;Future;Generations;Genetic;genetic approach;Genetic Engineering;Helper-Inducer T-Lymphocyte;Hematopoietic;Hematopoietic stem cells;HIV Infections;Homeostasis;Human;human stem cells;humanized mouse;Hypersensitivity;IL6 gene;IL7R gene;Immune;immune function;Immune response;Immune system;Immunodeficient Mouse;Immunofluorescence Immunologic;Immunotherapy;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;influenza infection;influenza virus vaccine;influenzavirus;Innate Immune Response;Interferon Type I;Interleukin-6;Interleukins;Knock-in;Knock-in Mouse;Knockout Mice;Liver;Lung;lung injury;Lymphoid;Lymphoid Tissue;Macrophage;Macrophage Colony-Stimulating Factor;Malignant Neoplasms;Measures;Modeling;monocyte;mouse development;mouse model;Mucosal Immune System;Mucosal Immunity;mucosal site;mucosal vaccine;Mucous Membrane;Mus;Myeloid Cells;National Institute of Allergy and Infectious Disease;Natural regeneration;next generation;novel;overexpression;Peripheral Blood Mononuclear Cell;permissiveness;Phenotype;Plasma Cells;Play;Population;Pre-Clinical Model;Property;Proteins;receptor;Research;respiratory colonization;respiratory smooth muscle;Respiratory Tract Infections;respiratory virus;response;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Source;Spleen;Stains;Stem Cell Factor;Stromal Cells;Structure;System;Systemic infection;T cell response;T-Lymphocyte;Testing;Thymic Tissue;tissue injury;Tissues;Transgenic Organisms;translational immunology;Transplantation;TSLP gene;United States National Institutes of Health;Vaccine Antigen;vaccine development;Vaccines;Virus

PROJECT_TITLE: Novel humanized mouse model of mucosal immunity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This project aims to explore the natural human mechanism, to use so-called heat shock proteins, to retain protein homeostasis and prevent the formation of toxic protein aggregates. Such aggregates are found in different illnesses such as Alzheimer's disease but nothing is known how they become toxic. Completion of the proposed objectives will provide valuable insights about how healthy individuals prevent such toxicity and this may provide therapeutic strategies against Alzheimer's disease.

PI_NAMEs: HEGETSCHWEILER, MARIELLE AULIKKI (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: abeta accumulation;Adopted;Affect;Alzheimer's Disease;American;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid Fibrils;Attention;Bacteria;beta pleated sheet;Binding;Binding Sites;Career Mobility;Cell Line;Cells;Communication;Cryoelectron Microscopy;Cytoprotection;Deposition;Development;Disease;Disease Progression;Encapsulated;Equilibrium;Evolution;experimental study;extracellular;flexibility;Funding;Heat shock proteins;Human;Individual;insight;Knowledge;Mammals;Measurement;Methods;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Chaperones;Molecular Conformation;Monitor;monomer;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Organism;overexpression;Peptides;Phase;Play;pressure;prevent;Prevention;Principal Investigator;Process;protein aggregation;protein folding;protein misfolding;Proteins;proteostasis;Reaction;Reactive Oxygen Species;Relaxation;Research;Resolution;Role;Sampling;Site;Specificity;Stress;stressor;Structure;System;Therapeutic;Toxic effect;Training;Yeasts

PROJECT_TITLE: Towards the understanding of how chaperones function and prevent amyloidogenic diseases

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Neurosciences;Substance Misuse

PI_NAMEs: YATES III, JOHN R (contact)

PROJECT_TERMS: Acetylation;Affinity Chromatography;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol response;alcohol use disorder;Analytical Chemistry;Animal Model;Area;brain control;Brain region;brain tissue;Cell Physiology;Cells;Cellular Neurobiology;Center for Translational Science Activities;Chemistry;Collaborations;Consultations;Data;Data Analyses;disease model;Electrophysiology (science);Experimental Designs;experimental study;Gene Expression;Gene Expression Profile;Goals;Human Resources;improved;Mass Spectrum Analysis;Measurement;Measures;Methods;Molecular;Mus;neural circuit;neuronal circuitry;Neurons;neuroproteomics;Outcome;patch clamp;Pathway interactions;phosphoproteomics;Phosphorylation;Physiological;Post-Translational Protein Processing;Protein Analysis;Protein Biosynthesis;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;proteostasis;Rattus;Regulatory Element;Research Institute;Research Personnel;response;sample collection;Sampling;single-cell RNA sequencing;Tissues;Work

PROJECT_TITLE: Neuroproteomics Core - Yates


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative There is an urgent need to better understand the genetic regulatory mechanisms that affect antibiotic synthesis operons, as this information will influence the strategies used for discovering novel antibiotics and will lead to new tools for improving heterologous production of antibiotics. We recently discovered a new family of transcription elongation factors called LoaP, which we hypothesize are broadly used for regulation of antibiotic synthesis operons. In this project, we will reveal the genetic regulatory strategy used by this important protein and show how its molecular mechanism provides unique and fundamental insight into the workings of the transcription elongation complex.

PI_NAMEs: WINKLER, WADE  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Affinity;Anabolism;Antibiotics;antitermination;Bacillus;Bacteria;Base Sequence;Binding;Biochemical;Bioinformatics;Bypass;C-terminal;collaborative approach;Complex;Data;Dedications;Development;DNA-Directed RNA Polymerase;Experimental Genetics;experimental study;Family;Gene Expression;gene synthesis;Genes;Genetic;genetic regulatory protein;Genetic Transcription;improved;In Vitro;in vivo;insight;intermolecular interaction;Investigation;Knowledge;Life;Maps;Molecular;Molecular Genetics;Mutation;N-terminal;Names;novel;Operon;Organism;paralogous gene;Pathway interactions;Peptide Initiation Factors;Play;Polysaccharides;Production;protein protein interaction;Proteins;reconstitution;recruit;Regulation;Regulon;Resolution;rho;Ribonucleoproteins;RNA;RNA Binding;Role;Signal Transduction;Site;Structure;Subgroup;termination factor;tool;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Elongation Factors;virtual

PROJECT_TITLE: Processive Antitermination of Antibiotic Synthesis Genes

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This work will markedly enrich MARBLES resources and expedite collaborative sharing for one of the only enriched-risk autism cohorts in the U.S. with prospectively-collected pregnancy data and biosamples and deep evaluation of risk factors, mediators, and outcomes, to advance discovery of etiologic factors and early biomarkers for ASD, while more thoroughly adjusting for confounding factors including those resulting from structural racism, and will add understanding of how experienced discrimination plays a role in these autism- affected families’ care and well-being.

PI_NAMEs: CHAMBERS, BRITTANY D.;SCHMIDT, REBECCA JEAN (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Affect;Area;autism biomarker;Autism Diagnosis;autism spectrum disorder;autistic children;bilingualism;biobank;Biological Markers;Caring;Child;Clinical;Clinical assessments;clinical care;Clinical Services;cohort;Collection;community engagement;Community Outreach;contextual factors;Data;data sharing;Databases;deprivation;design;Diet;early detection biomarkers;economic indicator;Education;Enrollment;Environmental Exposure;Environmental Health;environmental justice;Environmental Risk Factor;Epidemiology;Equity;Ethnic Origin;Etiology;Evaluation of Risk Factors;experience;factor A;Family;follow-up;Future;Green space;high risk;Home;Immune;improved;indexing;Individual;Infrastructure;Investments;Language;Learning;Life Style;Link;Lived experience;Low Prevalence;Measurement;Measures;Mediator;Medical History;Methylation;Neighborhoods;neurodevelopment;Neurodevelopmental Disorder;Nutrient;Outcome;Participant;participant enrollment;perceived discrimination;Personal Satisfaction;population based;postnatal;postnatal period;Pregnancy;prenatal;Prevalence;prospective;Protocols documentation;Race;Recording of previous events;recruit;Research Personnel;Resource Sharing;Resources;Risk;Sample Size;Sampling;shared database;Siblings;Site;sociodemographic disparity;sociodemographic factors;sociodemographics;socioeconomics;Spanish;Specimen;Structural Racism;System;tool;Update;Urbanicity;Visit;walkability;web site;Work

PROJECT_TITLE: BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

PROJECT_TERMS: Abstinence;alcohol effect;alcohol research;Alcohols;Animal Model;Animals;Back;Behavior assessment;Behavior monitoring;Behavioral;Biochemical;Biological Assay;Blood alcohol level measurement;Cellular Neurobiology;Chronic;chronic alcohol ingestion;comparison control;Consultations;Cost Savings;Data;Dependence;Development;drinking;Equipment;Ethanol;Experimental Designs;experimental study;Exposure to;Foundations;Funding;Gases;Goals;Heavy Drinking;Injections;Instinct;Laboratories;Labyrinth;Lead;Leadership;learning strategy;Measures;Mission;model development;Modeling;Mus;novel;Pattern;Phenotype;prevent;Procedures;Pyrazoles;Quality Control;Rattus;Recording of previous events;Research;Research Institute;Research Personnel;Resources;response;Running;sample collection;Sampling;Secondary to;Services;Site;Standardization;Statistical Data Interpretation;System;Techniques;Time;vapor;Video Recording;Withdrawal;Work

PROJECT_TITLE: Animal Models Core - Roberts


NIH_SPENDING_CATS: Congenital Structural Anomalies;Infant Mortality;Pediatric;Rare Diseases;Spina Bifida

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Neural tube defects (spina bifida and anencephaly, for example) constitute the second-most common class of birth defects, resulting in significant suffering and monetary costs: ~$1 billion total in hospitalization costs for all US patients each year. This proposal seeks to understand mechanisms of apical constriction, a change in cell shape that contributes to successful neural tube closure, using the roundworm C. elegans as a simple model for efficient investigation of cellular and molecular mechanisms. The long-term goal of the work is to understand fundamental mechanisms that can lay a foundation for future diagnosis and prevention of neural tube defects.

PI_NAMEs: GOLDSTEIN, ROBERT P (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Anencephaly and spina bifida X linked;Animals;Apical;Basic Science;Biological;Biological Models;Caenorhabditis elegans;Cell Shape;Cells;Cellular biology;Complex;Congenital Abnormality;constriction;Development;Developmental Biology;Diagnosis;Event;Financial cost;Foundations;Future;gastrulation;Goals;Hospital Costs;improved;in vivo;innovation;insight;Investigation;Laboratories;Modeling;Molecular;Morphogenesis;Motor Activity;motor control;Nematoda;Neural tube;Neural Tube Closure;Neural Tube Defects;novel;Patients;Pattern;polarized cell;Prevention;Research;Series;Shapes;tool;transmission process;Vertebrates;Work

PROJECT_TITLE: C. elegans gastrulation: A model for understanding apical constriction mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The SPURS program addresses the lack of diversity in biomedical research, which is rooted in the limited number of under-represented students entering the field of science, ultimately affecting the goals and direction of research. Underserved communities suffer from a lack of representation at the decision-making level in science, in terms of policy issues and the determination of priorities for conducting research. Therefore, the SPURS program addresses the critical need to increase the pipeline of highly qualified trainees into neuroscience.

PI_NAMEs: GRUEBER, WESLEY B (contact);SIEGELBAUM, STEVEN A

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Affect;African American;Alaska Native;Area;Award;Bachelor's Degree;biological research;Biomedical Research;Black race;career;career development;Cities;college;Cultural Sensitivity;Decision Making;Degree program;design;disadvantaged student;Disparity;Doctor of Medicine;Doctor of Philosophy;economic disparity;Education;Engineering;Enrollment;Ethics;experience;experimental analysis;Faculty;faculty mentor;Fostering;Fright;Funding;Generations;Genetic;Goals;Graduate Degree;graduate school;Grant;hands on research;Health;Hispanic;Individual;Institution;interest;Journals;Laboratories;Latino;lectures;Literature;medical schools;Medicine;meetings;Mentors;Mentorship;Minority;minority student;minority trainee;Mission;Names;National Institute of Neurological Disorders and Stroke;Native Americans;Neurosciences;Neurosciences Research;New York;Oral;Pacific Islander;Participant;Patient Care;Persons;Physicians;Play;Policies;Positioning Attribute;Postbaccalaureate;posters;Preparation;Principal Investigator;programs;Qualifying;Reading;Research;Research Methodology;Research Personnel;Research Training;Resources;Risk;Role;role model;Scholarship;Science;Scientist;social;Students;summer program;summer research;Surgeon;Talents;Training;Training Programs;translational neuroscience;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;underserved community;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: ROBERTO, MARISA  (contact)

PROJECT_TERMS: Abstinence;addiction;alcohol abstinence;Alcohol consumption;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Animal Model;Animals;antagonist;Anxiety;anxiety-like behavior;associated symptom;Astrocytes;Behavior;behavior test;Behavioral;behavioral phenotyping;biological adaptation to stress;Biological Assay;Brain;Cell Nucleus;Cells;Cellular Neurobiology;Chronic;Collaborations;Complement;Corticotropin-Releasing Hormone;CRF receptor type 1;Data;Dependence;designer receptors exclusively activated by designer drugs;Disease;drinking;driving force;Drug Addiction;drug candidate;drug testing;Dynorphins;dysphoria;Electrophysiology (science);Emotional;emotional symptom;Ethanol;Ethanol dependence;executive function;Female;Functional disorder;gamma-Aminobutyric Acid;Genetic;genetic testing;Glutamates;Goals;Heavy Drinking;hippocampal pyramidal neuron;hypocretin;Impairment;In Situ Hybridization;Infusion procedures;insight;Intake;Investigation;Label;Lead;male;Medial;Mediating;Nature;negative affect;negative emotional state;neuroadaptation;Neurons;Neuropeptides;neurophysiology;neuroproteomics;Neurotransmitters;nociceptin;Opioid Receptor;Output;patch clamp;Pathway interactions;Peptides;Prefrontal Cortex;Property;Proteins;Proteomics;Psychological reinforcement;Rattus;receptor;recruit;Relapse;Research;Role;Signal Transduction;Site;Slice;Stress;stress reduction;symptomatology;Synapses;System;Techniques;Testing;transmission process;Withdrawal;Withdrawal Symptom;withdrawal-induced anxiety

PROJECT_TITLE: Neurophysiology Component - Roberto


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Brain-computer interfaces must enable robust and generalizable control of assistive devices in uncontrolled environments, such as the home. Through this proposal, we will study how the physical or cognitive state of a participant impact neural activity and system performance. In addition, we will characterize the extent to which experience- or training-induced motor learning can drive neural plasticity and improve BCI robustness.

PI_NAMEs: COLLINGER, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acceleration;Automobile Driving;Biomimetics;brain computer interface;Calibration;Clinical;clinical translation;Cognitive;Computer software;Computers;Custom;Data;design;Development;Devices;Dimensions;Disabled Persons;distraction;Elements;Environment;environmental change;Environmental Risk Factor;experience;experimental study;Fatigue;Goals;grasp;Home;Home environment;home test;improved;Intervention;Knowledge;Laboratories;Laboratory Study;Learning;Lighting;Limb structure;Longitudinal Studies;Measures;Monitor;Motion;Motor Cortex;motor learning;Movement;Mus;neural;neural patterning;neuromechanism;Neuronal Plasticity;neurotransmission;Noise;Output;Pain;Participant;Pattern;Performance;Physiological;Population;population based;portability;Positioning Attribute;Posture;Property;Quality of life;response;Self-Help Devices;Signal Transduction;skills;Source;Speed;Stable Populations;Stress;System;Technology;Testing;Time;Training;Translating;Translations;visual tracking

PROJECT_TITLE: Quantifying neural variability and learning during real world brain-computer interface use

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LOWELL

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Doxorubicin is one of the most efficacious anticancer agents in the treatment of several solid tumors as well as hematological malignancies, but its utility is severely limited by its induction of cardiotoxicity and cardiomyopathy. This occurs due to the ability of doxorubicin to promote the accumulation of redox-active iron into the cardiac mitochondria, but current iron chelators do not offer clinical benefits since they are mitochondrial-inaccessible or impede doxorubicin’s antitumor efficacy. We report a new class of a small molecule that provides selective and efficient iron removal from the mitochondria without affecting doxorubicin’s antitumor activity, which has the potential to revolutionize approaches in many anthracycline- based cancer therapies.

PI_NAMEs: KIM, JONGHAN  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 4T1;Acute leukemia;Affect;Affinity;analog;Anthracycline;anti-cancer;anticancer activity;Antineoplastic Agents;Apoptosis;Binding;Biogenesis;Breast Cancer Cell;Cancer Patient;Cancer Survivor;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cell Nucleus;Cells;Cessation of life;Chelating Agents;chelation;chemotherapy;Circulation;Clinical;clinical efficacy;clinically relevant;comparative efficacy;Cytosol;cytotoxic;Data;Deferoxamine;Dexrazoxane;Disease Management;DNA biosynthesis;DNA Damage;DNA topoisomerase II alpha;DNA Topoisomerases;Dose;Doxorubicin;Drug Kinetics;Echocardiography;efficacy validation;Electron Microscopy;Enzymes;Excision;FDA approved;Free Radicals;Generations;Genetic;Heart;Heart Diseases;heart function;Hematologic Neoplasms;Homeostasis;Human;human induced pluripotent stem cells;Impairment;Implant;improved;Inbred BALB C Mice;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Intervention;Iron;Iron Chelation;Iron Overload;Malignant Neoplasms;MDA MB 231;Measures;Membrane;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monitor;Mus;Myelosuppression;Myocardial dysfunction;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncologist;Outcome;Oxidation-Reduction;oxidative damage;patient derived xenograft model;Patients;Periodicals;Permeability;Pharmaceutical Preparations;pharmacologic;Pilot Projects;preservation;prevent;Prognosis;Rattus;Reporting;Risk Factors;Safety;Science;small molecule;Solid Neoplasm;Structure;success;Survivors;Therapeutic;Therapeutic Index;Therapeutic Intervention;therapeutic target;Topoisomerase;tumor;tumor progression;Zebrafish

PROJECT_TITLE: Mitochondrial iron export therapy for doxorubicin-induced cardiotoxicity

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Eye Disease and Disorders of Vision;Heart Disease;Neurosciences;Stroke

PHR: Project narrative: Patients with end-stage congestive heart failure are increasingly treated with mechanical circulatory support, which unfortunately leads to high rates of hemorrhagic strokes. This study will examine the biological effects on the brain of patients treated with non-pulsatile mechanical circulatory support.

PI_NAMEs: WILLEY, JOSHUA ZEBADIAH (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Adverse event;Age;Anatomy;Angiography;Anticoagulants;Anticoagulation;arterial stiffness;arteriole;Biological;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Circulation;Blood flow;Blood Pressure;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Blood-Retinal Barrier;Brain;Brain hemorrhage;Cardiac Output;Cause of Death;Central Nervous System;Cephalic;cerebral autoregulation;Cerebral endothelium;Cerebral hemisphere hemorrhage;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Clinical;clinically significant;Cognition;cognitive change;Congestive Heart Failure;design;Device Designs;Disease;endothelial dysfunction;Endothelium;Event;Exercise Tolerance;Fatality rate;Functional disorder;Gastrointestinal Hemorrhage;General Population;Generations;Goals;Heart Transplantation;Hemorrhage;Homeostasis;Human;Hypertension;implantation;improved;in vivo;in vivo imaging;indexing;individualized medicine;Interdisciplinary Study;Investigation;ischemic injury;Ischemic Stroke;left ventricular assist device;lifetime risk;Measures;mechanical circulatory support;Microcirculation;Morbidity - disease rate;mortality;Neuropsychological Tests;Neuropsychology;neurovascular;neurovascular unit;Observational Study;Operative Surgical Procedures;Optical Coherence Tomography;Outcome;Participant;Pathologic Processes;Patients;Pattern;Permeability;Physiological;Physiology;Population;Prevalence;Public Health;Reperfusion Injury;Research;Retina;retina circulation;retinal imaging;Risk Factors;risk stratification;Secondary to;Serum;Stroke;stroke therapy;Structure;Transplantation;Vascular Cognitive Impairment

PROJECT_TITLE: Neurovascular Consequences of Non-Pulsatile Flow from Left Ventricular Assist Devices

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT – PROJECT NARRATIVE Metastatic triple-negative breast cancer (TNBC) patients have poor clinical outcomes, in part, because there are no targeted therapies approved to treat this aggressive breast cancer subtype. By elucidating new post-translational mechanisms of eIF5A1/2-dependent TGFβ/fibronectin-induced heterogeneity and metastasis within primary and premetastatic niches, the proposed studies have the potential to identify new therapeutic strategies for abrogating TNBC progression. Additionally, this work has broad applicability across the field of oncology as many of the molecular regulators being investigated in this proposal have been reported to be altered or dysregulated in other solid tumor types where cancer metastasis is a primary cause of patient mortality.

PI_NAMEs: KELBER, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;aggressive breast cancer;Anti-Inflammatory Agents;Biochemistry;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cancer Biology;cancer cell;Cancer Prognosis;cancer subtypes;cancer type;Cell Cycle Kinetics;Cells;Cellular biology;Chemotherapy-Oncologic Procedure;Clinical;Complex;Cytoplasm;Data;Eukaryotic Initiation Factors;Fibronectins;Flow Cytometry;Funding;genetic manipulation;Goals;Heterogeneity;Human;Immunofluorescence Immunologic;improved;in vivo;Inflammatory;innovation;Integrins;Intervention;Invaded;Knowledge;Laboratories;LCN2 gene;Mediating;Methods;Modeling;Molecular;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;nucleocytoplasmic transport;Oncology;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Periodicity;pharmacologic;Pharmacology;Phosphotransferases;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programs;Proteins;public health relevance;Publishing;Reporting;Research;response;screening;Signal Transduction;Site;Solid Neoplasm;spatiotemporal;targeted treatment;Testing;Tissues;Transforming Growth Factor beta;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor progression;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Spatiotemporal mechanisms of eIF5A1/2-mediated metastasis in triple-negative breast cancer


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

PI_NAMEs: CONTET, CANDICE  (contact)

PROJECT_TERMS: Address;Air;alcohol abstinence;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Amino Acids;Amygdaloid structure;Animal Model;antagonist;Astrocytes;Automobile Driving;behavioral outcome;behavioral phenotyping;Brain;Cell Nucleus;cell type;Cellular Neurobiology;Chronic;chronic alcohol ingestion;Collaborations;Corticotropin-Releasing Hormone;CRF receptor type 1;Dose;Electrophysiology (science);emotional symptom;Ethanol;experimental study;extracellular;FOLH1 gene;functional outcomes;Funding;Gene Expression;genetic approach;Glutamate Transporter;Glutamates;hippocampal pyramidal neuron;Homeostasis;Human;Hypothalamic structure;Impairment;in vivo;inhibitor;insight;Intake;Interneurons;knock-down;Label;Lead;Link;Mass Spectrum Analysis;Medial;Mediating;Metabolic;metabotropic glutamate receptor 3;Microdialysis;Modeling;Molecular;Motivation;Mus;Neurobehavioral Manifestations;Neurons;Neuropeptides;neuroproteomics;Neurotic Disorders;neurotransmission;novel;Outcome;overexpression;pharmacologic;Phenocopy;Phenotype;pinacolyl methylphosphonic acid;postsynaptic;preclinical study;Prefrontal Cortex;Proteins;Proteome;proteomic signature;Proteomics;Receptor Signaling;Recording of previous events;Research;Research Institute;Resources;Rodent;Role;Sampling;sex;Signal Transduction;Slice;stem;Stress;Synaptic plasticity;Synaptic Transmission;Testing;translational approach;transmission process;uptake;Variant;Withdrawal

PROJECT_TITLE: Molecular Component - Contet


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Cell migration is critical to many physiological and pathological processes, including embryogenesis, wound healing, immune function, and cancer metastasis. Lamellipodia are thin, sheet-like protrusions that facilitate cell migration in diverse environments. This project combines high-resolution light-sheet microscopy, computer vision, and molecular biology techniques to study the formation and function of lamellipodia in 3D fibrous matrices.

PI_NAMEs: DRISCOLL, MEGHAN KATRIEN (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Actins;Adaptive Immune System;Address;Adhesions;Affect;Anthrax disease;Antigens;Biochemical;Biological Assay;Biological Models;cancer cell;cancer immunotherapy;cell motility;Cell Physiology;cell type;Cells;Cellular biology;cellular imaging;Cellular Morphology;Collagen;Collagen Fiber;Color;Communication;Complex;Computer Vision Systems;computerized tools;Confocal Microscopy;Coupling;Crowding;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Diffusion;Elements;Embryonic Development;Environment;Exhibits;Fibroblasts;Future;Generations;Geometry;Glass;Grant;Human;Image;Image Analysis;imaging modality;Immune;immune function;Immune system;Immunity;in vivo;Investigation;Laboratories;Lead;Light;light microscopy;Location;lymph nodes;lymphatic vessel;Macrophage;Maintenance;Measures;Membrane;Microscope;Microscopic;microscopic imaging;Microscopy;migration;Modeling;Molecular;Molecular Biology Techniques;Morphology;movie;Neoplasm Metastasis;Neural Crest Cell;novel;pathogen;Pathologic Processes;Penetration;Peripheral;Phase;Physiological Processes;polymerization;Polymers;predictive modeling;Property;Proteins;recruit;Regulation;Resolution;Sentinel;Shapes;Signal Transduction;Slice;spatiotemporal;Structure;Surface;System;T-Lymphocyte;Techniques;temporal measurement;Testing;Thinness;Three-Dimensional Image;Tissues;tool;Training;Tuberculosis;Virus;Visualization;Work;wound healing

PROJECT_TITLE: Formation and function of lamellipodial morphology in 3D microenvironments