ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Mutations in the SHANK3 gene are a well-established risk factor for ASD. This proposal aims to delineate how SHANK3 deficiency causes cellular and molecular malfunctions that underlie abnormal neural circuitry and social and reward behaviors using two novel mouse models. These studies may lead to identifying novel therapeutic targets for treating social and reward deficits in ASD and other neuropsychiatric disorders.

PI_NAMEs: FOLKES, OAKLEIGH  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: autism spectrum disorder;Behavior;Behavioral;Behavioral Paradigm;Binding;Biological Assay;Bipolar Disorder;Calcium;Characteristics;Cues;Data;density;Dopamine D1 Receptor;Etiology;Exons;experimental study;Fragile X Syndrome;Functional disorder;Genes;Genetic;Goals;Image;Immunohistochemistry;in vivo;Investigation;Knock-out;Measures;metabotropic glutamate receptor 5;Methodology;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;neural circuit;Neurons;neuropsychiatric disorder;new therapeutic target;novel;Nucleus Accumbens;optogenetics;Point Mutation;Population;post-doctoral training;postsynaptic;preference;Proline-Rich Domain;Proteins;Psychological reinforcement;recruit;Research;Research Domain Criteria;Research Personnel;response;Rewards;Risk Factors;Role;scaffold;Scaffolding Protein;Schizophrenia;social;Social Behavior;social deficits;Social Interaction;Synapses;Techniques;Testing;Time;Western Blotting

PROJECT_TITLE: Investigations of Neuronal Ensembles and Shank3-Homer Scaffolds on Reward and Social Behavior in a Shank3 model of Autism


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Children with Attention Deficit Hyperactivity Disorder (ADHD) are at substantially increased risk for long-term difficulties into adulthood, including academic underachievement, substance abuse, and criminal behavior. In our effort to improve these outcomes, we have worked on identifying highly-reliable motor measures that could be used to help better guide ADHD treatment, leading to the discovery of two brain-based measures that are abnormal in children with ADHD and, importantly, also predict the severity of ADHD behaviors. We aim to determine whether these two measures, performed with brief and safe Transcranial Magnetic Stimulation (TMS), are reliable and meaningful enough to be used to help improve precision of individually-targeted and effective ADHD treatments.

PI_NAMEs: GILBERT, DONALD L (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: 12 year old;Acute;Address;Adult;Adverse event;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior Therapy;Behavioral;Biological Markers;biomarker development;biomarker performance;biomarker validation;Blinded;brain based;Categories;Child;Childhood;Cities;Clinical;clinical practice;Clinical Trials;clinically relevant;Cognitive;cognitive control;criminal behavior;Data;design;Diagnosis;Diagnostic;Disease;distraction;Dopamine;Dose;effective intervention;Emotional;Evaluation;follow-up;Foundations;Friends;Functional disorder;Funding;Future;Genetic;Grant;Hand;Impairment;improved;improved outcome;Individual;innovation;inpatient psychiatric treatment;Intervention;Investigation;Link;Measures;Membrane Potentials;Mental disorders;Methods;Modeling;Motor;motor control;Motor Cortex;Motor Evoked Potentials;Muscle;Negative Valence;neurochemistry;neurophysiology;novel;Outcome;Parents;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology Study;Physiological;Physiology;Placebo Control;Placebos;potential biomarker;Precision therapeutics;prognostic;psychostimulant;Publishing;Reaction Time;Research;Research Domain Criteria;response;Rest;Rewards;Risk;Risk Factors;Ritalin;School-Age Population;Selection for Treatments;Severities;Signal Transduction;Site;Stimulant;Subgroup;Substance abuse problem;Surface;Symptoms;System;Testing;Transcranial magnetic stimulation;treatment strategy;Underachievement;Validation;Work

PROJECT_TITLE: 1/2 - Anomalous Motor System Physiology in ADHD: Biomarker Validation and Modeling Domains of Function

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Neurodegenerative;Neurosciences;Peripheral Neuropathy

ORG_CITY: AUGUSTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Diabetic gastroparesis is a significant complication of diabetes associated with symptoms of uncontrolled nausea, vomiting, sensation of feeling full quickly after eating, becoming full rapidly, abdominal pain, and bloating. There are limited, effective treatments for this condition, which is related to disruption of the brain-gut axis. This proposal aims to evaluate a novel treatment using repetitive magnetic stimulation targeting the spinal nerves in the thoracic region, ThorS-MagNT, as a potential treatment for diabetic gastroparesis in a randomized controlled trial (TNM-DGp Trial) and understand how it works.

PI_NAMEs: KUO, BRADEN ;SHARMA, AMOL  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Address;Adult;Affect;arm;Autonomic Dysfunction;autonomic reflex;Cardiovascular system;Chest;Complications of Diabetes Mellitus;debilitating symptom;design;Development;diabetes management;Diabetes Mellitus;diabetic gastroparesis;diaries;Disabled Persons;Disease;Dose;Eating;effective therapy;efficacious treatment;efficacy testing;Esthesia;Evoked Potentials;Feeling;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Galvanic Skin Response;Gastroparesis;Goals;gut-brain axis;improved;Incidence;indexing;insight;Insula of Reil;Insulin-Dependent Diabetes Mellitus;Limbic System;Magnetic Resonance Imaging;Magnetism;Measures;Motility;multiphase optimization strategy;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Neuropathy;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Outcome Measure;Peripheral;Pilot Projects;Placebos;primary outcome;Primitive foregut structure;Process;Quality of life;Randomized;Randomized, Controlled Trials;response;Safety;Satiation;secondary outcome;Sensorimotor functions;Sensory;Severities;Signal Transduction;source localization;Spinal nerve structure;Splanchnic Nerves;Stimulus;Stomach;Structure;symptomatic improvement;Symptoms;Testing;TNM;United States National Institutes of Health;Visceral Afferents;Vomiting;Work

PROJECT_TITLE: Thoracic Neuromodulation for Diabetic Gastroparesis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed study represents an important step in understanding why offspring of depressed mothers are at increased risk for depression themselves and will help to clarify the development of a key risk factor, attentional biases for facial displays of sadness, and its role as a mechanism of risk for the intergenerational transmission of depression. These results could help provide important information not only about where to intervene but when to intervene with offspring of depressed mothers. As such, the results could pave the way for more focused interventions for at-risk youth.

PI_NAMEs: GIBB, BRANDON E (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 14 year old;Adolescence;Adolescent;Adult;Affective;Age;age related changes;aged;Anxiety;Anxiety Disorders;Attention;attentional bias;Child;child depression;Childhood;cognitive process;Computers;Cues;Depressed mood;depressive symptoms;design;Development;Diagnosis;directed attention;disability;Disease;disorder risk;Early Intervention;Electroencephalography;emotion regulation;Emotional;Emotions;Event-Related Potentials;Exhibits;Face;follow up assessment;follow-up;gaze;indexing;Individual;Infant;innovation;interest;intergenerational;Intervention;Life;Life Stress;Link;Location;Major Depressive Disorder;maternal depression;Measures;Mental Depression;Methods;Modeling;Mothers;Nature;neural;offspring;Pattern;Prevention;preventive intervention;Process;Property;prospective;Proxy;Psychometrics;Psychopathology;Puberty;Reaction Time;Recording of previous events;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Role;rumination;sex;Sex Differences;social;Specificity;Standardization;Stress;sustained attention;Testing;theories;therapy design;Time;Transact;transmission process;visual tracking;Youth

PROJECT_TITLE: Attentional Biases for Affective Cues as a Mechanism of Risk in Children of Depressed Mothers

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Frontotemporal dementia (FTD) and the related disease amyotrophic lateral sclerosis (ALS) are currently untreatable neurodegenerative conditions. This application develops and validates a novel three dimensional human iPSC based microphysiologic model of cortex from patients with FTD/ALS due to mutations in the C9orf72 gene, to identify novel translatable biomarkers for assessment of candidate therapeutics.

PI_NAMEs: SVENDSEN, CLIVE NIELS (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: 3-Dimensional;Age;Aging;Agonist;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Area;Astrocytes;Autologous;Autopsy;Behavioral;Biological Assay;Biological Markers;Biological Models;biomarker identification;biomarker validation;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;C9ALS;C9FTD;c9FTD/ALS;C9ORF72;Cause of Death;cell cortex;Cell Death;Cell Line;Cell model;cell type;Cells;Cessation of life;Clinical;Clinical Data;clinical development;Clinical Pathology;clinical predictors;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Degenerative Disorder;Dementia;Devices;Diagnosis;Disease;disease phenotype;early phase clinical trial;efficacy testing;Etiology;Event;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Mutation;Genes;Genetic;Goals;Human;human induced pluripotent stem cells;human tissue;Image;In Vitro;induced pluripotent stem cell;Industry Collaboration;inhibitor;Intervention Trial;Language;Liquid substance;Measures;Memory;Microglia;microphysiology system;Mitochondria;Modeling;Monitor;motor neuron degeneration;Motor Neurons;multiple omics;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;Nuclear RNA;Organ;organ on a chip;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;patient response;patient stratification;Patients;Phenotype;Physiological;preclinical efficacy;predictive marker;Prosencephalon;protein aggregation;repository;Reproducibility;Respiratory Failure;response;response biomarker;RIPK1 gene;safety testing;small molecule;Spinal;Syndrome;System;TDP-43 aggregation;technology platform;Temporal Lobe;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic evaluation;Therapeutic Trials;Tissues;Toxic effect;trafficking;transcriptome sequencing;transcriptomics;Treatment Efficacy;Validation;Variant;virtual;virtual clinical trial

PROJECT_TITLE: A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative: DNA replication restart is an important process to study from a human health perspective because knowing more about how DNA is properly maintained will help to identify targets to kill selectively the deleterious, malignant or disease-causing cells that may plague our bodies (cancer and pathogenic organisms). Conversely, this knowledge may also help to augment basic health and longevity of our bodies by the design of better antibiotics. This may be translated into a longer, healthier life for individuals.

PI_NAMEs: KECK, JAMES L (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antibiotics;Back;Bacteria;Bacterial DNA;Binding;Biochemical;Biological;Cells;Complex;Coupled;crosslink;Cryoelectron Microscopy;Data;design;Disease;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;DNA Structure;Ensure;Escherichia coli;experimental study;Funding;Genetic;genetic approach;Genetic study;Genomics;Goals;Health;helicase;Human;In Vitro;Individual;insight;Knowledge;Life;Link;Longevity;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Organism;Pathogenicity;Pathway interactions;Plague;premature;prevent;Process;protein complex;Proteins;Reaction;recruit;Regulation;Replication Initiation;Role;Site;Structure;System;Translating;Visualization

PROJECT_TITLE: Structure and Function of the Bacterial Primosome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Mental Health;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Increased rates of psychiatric symptoms during adolescence significantly impact health and well-being during this period of life and into adulthood, and are robustly associated with variation in pubertal timing and tempo. Identifying mechanisms underlying pubertal risk for psychopathology is complicated by multiple layers of hormonal, genetic, and contextual influences on both puberty and psychopathology that unfold over time, and that may operate through both sex-specific and generalized pathways. Defining the genomic architecture across physical and hormonal markers of puberty and examining links with psychopathology across the lifespan in both sexes will enable researchers to better disentangle multilayered mechanisms driving pubertal risk for lifecourse psychopathology.

PI_NAMEs: PATTERSON, MEGAN WALES (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Architecture;Automobile Driving;Behavioral;biobank;Brain;Childhood;cognitive development;Complex;Data;Development;Dimensions;early adolescence;Equation;Estradiol;Event;Face;Female;Genetic;genetic architecture;genetic association;Genetic Models;Genome;genome wide association study;Genomic approach;genomic locus;genomic signature;Genomics;Genotype;Grain;Growth;Hair;Health;Hormonal;Human;improved;Individual Differences;insight;Life;Life Cycle Stages;life span;Link;Literature;Longitudinal Studies;male;Measures;Menarche;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;Morbidity - disease rate;mortality;Nature;non-genetic;novel;Outcome;Pathway interactions;Personal Satisfaction;Phenotype;physical conditioning;Prevalence;Psychiatric Diagnosis;psychiatric symptom;Psychopathology;pubertal timing;Puberty;Publishing;rate of change;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Taking;Sampling;sex;Sex Differences;Sex Differentiation;Sex Hormone-Binding Globulin;sexual dimorphism;Signal Transduction;Site;Source;Staging;statistics;Structure;Symptoms;Testosterone;Time;tool;Training;trait;Variant;Voice;Youth

PROJECT_TITLE: Defining the multivariate genomic signature of pubertal markers and impact on lifespan psychopathology

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Stroke;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PUBLIC HEALTH RELEVANCE Stroke and premature death are disproportionately high in people living with HIV. A current study led by Dr. Riley considers how combinations of drugs and inflammation exacerbate conditions that precede stroke. The objective of the current proposal is to expand the existing research to consider tryptophan catabolism as an additional physiological pathway of stroke- related conditions, and augment mentoring activities alongside the research. This comprehensive program will provide an effective training environment for mentees conducting patient-oriented research. At the same time, it will facilitate the development of clinical tools for risk assessment to reduce stroke in people living with HIV.

PI_NAMEs: RILEY, ELISE D. (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Age;Alcohols;amphetamine use;antiretroviral therapy;Attention;Biological Markers;Blood;Body mass index;California;Cannabis;cardiovascular risk factor;career;career development;Catabolism;CD4 Lymphocyte Count;cerebrovascular;Cerebrovascular Disorders;Cessation of life;Clinical;clinical development;Cocaine;cocaine use;Cocaine use disorder;Communicable Diseases;Complement;Consequences of HIV;cost effective;Data;Drug Combinations;Drug usage;early-career faculty;Environment;Enzymes;Epidemiologist;experience;Failure;Functional disorder;Funding;Goals;Health;Healthcare;HIV;HIV Infections;Immune System Diseases;improved;Individual;Infarction;Inflammation;Inflammatory;inflammatory marker;insight;interest;Interview;Investigation;Knowledge;Kynurenine;Learning;Link;Low Income Population;Magnetic Resonance Imaging;Measures;Medicine;Mentors;Microvascular Dysfunction;Modernization;mortality;multiple drug use;National Institute of Drug Abuse;Opioid;Opioid Analgesics;Parents;Pathway interactions;patient oriented research;Persons;Pharmaceutical Preparations;Physiological;polysubstance use;Postdoctoral Fellow;premature;professor;programs;public health relevance;Recommendation;recruit;Research;research and development;Research Personnel;Research Project Grants;response;Risk;Risk Assessment;risk stratification;San Francisco;Science;skills;Stroke;stroke risk;T-Cell Proliferation;Time;Tobacco;tool;Toxicology;Training;training opportunity;Tryptophan;Tryptophan 2,3 Dioxygenase;Universities;Viral;Viral Load result;virtual;Visit;Woman

PROJECT_TITLE: Mentoring patient-oriented research on the health consequences of polydrug use

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: This proposal is focused on two proteins widely involved in human cancers: the Fbw7 ubiquitin ligase, a tumor suppressor that degrades cellular proteins, and Myc, a potent cancer driver that is targeted by Fbw7. We seek to understand the mechanisms that control protein degradation by Fbw7 and how this pathway is abnormal in tumors. This research may thus increase our understanding of how cancer develops and lead to new cancer treatment strategies.

PI_NAMEs: CLURMAN, BRUCE E (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Ablation;Apoptosis;Area;Binding;c-myc Genes;Cancer Biology;cancer cell;cancer therapy;CCNE1 gene;Cell Physiology;Cell Proliferation;cell type;Cells;cellular engineering;Development;dimer;Dimerization;Engineering;Exhibits;Genetic Transcription;Genomic approach;Glycogen Synthase Kinase 3;glycosylation;Goals;Heterozygote;Human;Knock-in;Malignant Neoplasms;Metabolism;Missense Mutation;Modeling;Mus;Mutation;neoplastic;neoplastic cell;Normal Cell;notch protein;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Proliferating;protein degradation;Proteins;Regulation;Research;Role;Signal Pathway;Signal Transduction;Substrate Specificity;Testing;transcription factor;treatment strategy;tumor;Tumor Suppressor Proteins;tumorigenesis;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: The Fbw7 ubiquitin ligase network: normal and neoplastic functions

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Tricuspid regurgitation is associated with heart failure and death in children with Hypoplastic Left Heart Syndrome (HLHS). 3D echocardiography based quantification and modeling has significantly informed the understanding of the adult mitral valve dysfunction and repair, but similar progress in tricuspid valve repair in HLHS is prohibited by the lack of customizable modeling methods suitable for the tricuspid valve. The proposed study will create tricuspid valve computer modeling methods, including statistical shape analysis, and apply them to a large cohort of HLHS patients, allowing delineation of the relationship between 3D tricuspid valve structure and valve dysfunction(regurgitation) in HLHS, as well as the design of patient-specific repairs informed by 3D structural analysis.

PI_NAMEs: JOLLEY, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anatomy;Automobile Driving;Biological Markers;Cessation of life;Child;Circulation;cohort;Complex;Computer Models;congenital heart abnormality;Decision Making;design;Development;Disease;experience;flexibility;Functional disorder;Future;Goals;Heart;Heart failure;Hypoplastic Left Heart Syndrome;Image;image processing;improved;indexing;Individual;individual patient;Infant;Infrastructure;innovative technologies;Investigation;Knowledge;Left;Methodology;Methods;Mitral Valve;Modality;Modeling;novel;open source;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Philadelphia;Population;Quality of life;repaired;Retrospective cohort study;Right ventricular structure;shape analysis;Shapes;Structural defect;structural heart disease;Structure;three dimensional structure;Three-Dimensional Echocardiography;three-dimensional modeling;tool;Tricuspid Valve Insufficiency;Tricuspid valve structure;United States;Universities;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Computer Modeling of the Tricuspid Valve in Hypoplastic Left Heart Syndrome

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The fact that vGPCR plays a key role in KSHV oncogenesis and that it is a member of protein family frequently targeted by FDA-approved drugs makes vGPCR a promising target for therapeutic intervention We will use biochemical methods and signaling assays to understand structural insight of vGPCR and to develop novel therapeutic nanobodies for inhibiting the oncogenic function of vGPCR.

PI_NAMEs: JUNG, JAE U (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: 3-Dimensional;Agonist;Antibodies;Binding;Biochemical;Biological Assay;Cancer Etiology;Cell surface;cell transformation;Cells;Cessation of life;chemokine;Chromium;Clinical Trials;clinically relevant;Cryoelectron Microscopy;Crystallization;CXCL1 gene;Cyclic AMP;Development;Disease;Disulfides;Drug Targeting;Epithelium;Etiology;extracellular;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Transcription;Genome;Genomics;Goals;Health;Health Status;Herpesviridae Infections;HIV;HIV/AIDS;Homologous Gene;Human;Human Biology;Human Herpesvirus 8;Immunoglobulin G;In Vitro;in vivo;Insecta;insight;Kaposi Sarcoma;Ligands;lytic replication;Malignant lymphoid neoplasm;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Mediator;member;Methods;milligram;mouse model;Mus;nanobodies;novel therapeutic intervention;novel therapeutics;Nude Mice;Oncogenic;oral cavity epithelium;Organoids;paracrine;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Protein Engineering;Protein Family;Proteins;Protocols documentation;Public Health;receptor;receptor binding;Recombinants;Regulation;Resolution;Sampling;screening;Second Messenger Systems;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;three dimensional cell culture;Three-dimensional analysis;Tissues;transcriptome;Treatment Efficacy;tumor;tumor growth;tumorigenesis;Viral;Viral Genes;Virus;Work

PROJECT_TITLE: Structural analysis and therapeutic nanobody development of KSHV G-protein coupled receptor


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Wound Healing and Care

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE I seek to characterize a novel dysregulation of inflammation resolution and resolution-dependent repair that may amplify disease in IBD but can nonetheless be disrupted therapeutically by exploiting a novel mucosal excretion pathway. I will investigate the mechanism by which macrophage efferocytosis stimulates human intestinal epithelial wound healing as a baseline against which to assess the potential dysregulating effects of elevated 12- and 15-hydroxyeicosatetraenoic acid (12- and 15HETE). I will also investigate the mechanisms by which the apolipoprotein A1 mimetic peptide 4F might disrupt HETE dependent dysregulation of this resolution and repair module.

PI_NAMEs: MERIWETHER, DAVID  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Agonist;antagonist;Anti-Inflammatory Agents;Apical;Apolipoprotein A-I;Apoptotic;Biopsy;Cell Communication;Cell model;Cells;Chronic;clinical remission;Crohn's disease;cyclooxygenase 2;Data;Disease;Eicosanoids;Epithelial Receptor Cell;epithelial repair;epithelial wound;Epithelium;Excretory function;G-Protein-Coupled Receptors;Goals;gut inflammation;healing;Homeostasis;Human;human model;Hydroxyeicosatetraenoic Acids;Immunosuppressive Agents;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;innovation;intestinal epithelium;Intestinal Mucosa;Knowledge;Ligands;lipid mediator;Macrophage;Measures;Methods;Modeling;mouse model;Mucous Membrane;multiple omics;Mus;Nature;Necrosis;neutrophil;novel;Oral;Organoids;Pathogenesis;Pathway interactions;Patients;peptidomimetics;pharmacologic;Phenotype;phosphoproteomics;Physiological;Polyunsaturated Fatty Acids;Population;pre-clinical research;prevent;Process;programs;Proteomics;receptor;Receptor Signaling;repaired;Reporting;Resolution;response;RNA Interference;Role;Signal Pathway;Small Intestines;System;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;Time;transcriptome sequencing;Ulcerative Colitis;Work;wound healing

PROJECT_TITLE: Dysregulation of inflammation resolution as therapeutic target for IBD

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: FREDERICK

ORG_NAME: BIOLOGICAL MIMETICS, INC.

ORG_STATE: MD

PHR: Narrative  Because of safety concerns surrounding the reversion of pathogenic phenotypes with the use of the oral poliovirus vaccine (OPV), WHO and other agencies recommend that inactivated poliovirus vaccines (IPV) be used in the final stages of global eradication and for post-eradication vaccinations. IPV is produced by inactivating purified virus by prolonged incubations with formalin which reduces the immunogenicity and leads to a relatively high price per dose compared with OPV.  In an SBIR Phase II funded by NIAID, we developed an improved polio vaccine that is safer to the population than OPV and safer and less costly to manufacture than IPV. The vaccine, ultraIPVTM, is killed using a novel UVC-inactivation process that is quick, reproducible, and produces more doses per milligram of virus than formalin inactivation. In this application, we propose to perform key IND-enabling studies to increase the value and attractiveness of the vaccine. Our long-term goals are to obtain IND approval, complete a Phase I clinical trial, and then out-license ultraIPVTM to a manufacturing partner. In this project, we will produce near- GMP vaccine material at a contract lab for safety and immunogenicity testing in GLP animal studies and prepare documents for IND approval to start clinical trials.

PI_NAMEs: TOBIN, GREGORY JOHN (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Amino Acids;Animal Model;Animals;Attenuated;biosecurity;Body mass index;Cells;Clinical Trials;Consumption;Containment;Contractor;Contracts;cost;Coupled;Data;Development;Dose;Engineering;Ensure;Environment;Epitopes;experience;Formalin;Formulation;Freezing;Funding;Future;Generations;Goals;Human;Human Resources;Immunization;Immunize;immunogenicity;improved;Inactivated Vaccines;Incubated;Injections;interest;irradiation;Licensing;manufacture;manufacturing facility;manufacturing organization;manufacturing process;manufacturing scale-up;meetings;member;method development;Methods;milligram;National Institute of Allergy and Infectious Disease;novel;novel vaccines;Oral Poliovirus Vaccine;Outcome;Output;pathogen;Pathogenicity;Phase;Phase I Clinical Trials;Phenotype;Poliomyelitis;Poliovirus Vaccines;Population;Price;Process;Production;Rattus;Reaction;Recommendation;recruit;Reporting;Reproducibility;Resistance;Running;Safety;safety assessment;safety study;Series;Serum;Small Business Innovation Research Grant;Talents;Technology;Technology Transfer;Testing;Toxicology;Update;Vaccination;vaccine candidate;Vaccines;Virus;Well in self;Wistar Rats

PROJECT_TITLE: Nonclinical Development of an Improved Polio Vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: GREENSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Natural products are a critical component of modern medicine and discovery of new molecules and pathways has the opportunity to positively impact human health. Using a multidisciplinary approach, this proposal seeks to combine diverse bioinformatic and biochemical methodologies to target new classes of RiPP natural products from across the tree of life and reveal their bioactivities. Our results will not only lead to the identification of new pathways and bioactive molecules, but will serve as a basis for future discovery and engineering efforts.

PI_NAMEs: CHEKAN, JONATHAN RODI (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Antibiotics;Artemisinins;bioactive natural products;Biochemical;Bioinformatics;Complement;Development;Elements;Engineering;Enzymes;Family;Future;Gene Cluster;Genome;graduate student;guided inquiry;Health;Human;in silico;insight;interdisciplinary approach;Lead;Life;Link;Logic;Methodology;Mining;Modern Medicine;Natural product discovery;Natural Products;Nature;next generation;novel therapeutics;Organism;Pathway interactions;Penicillins;peptide natural products;Peptides;Pharmaceutical Preparations;Postdoctoral Fellow;Process;Ribosomes;Scientist;secondary metabolite;Techniques;Training;Trees

PROJECT_TITLE: Bioinformatic Guided Discovery and Characterization of New RiPP Natural Products


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE: Development of L-DOPA-induced dyskinesias (LIDs) represents a major dose-limiting adverse effect associated with the long-term treatment of PD. Approximately, 10% of PD patients per year develop LIDs within the first 78 years of L-DOPA treatment and there are no effective treatments for either preventing the development of LIDs or reversing already established LIDs in PD patients. This work could have substantial impact on this critical unmet need as we aim to develop novel therapeutic approaches for the complications associated with chronic L-DOPA treatment in PD.

PI_NAMEs: HOPKINS, COREY R. (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Adrenergic Receptor;Adverse effects;Affect;analog;Animal Model;antagonist;Basal Ganglia;Behavior;Binding;Binding Proteins;Biological Assay;Bradykinesia;Brain;Brain region;Cell Nucleus;Cellular Assay;Characteristics;chemical synthesis;Chronic;Clinical;Clozapine;Complication;design;Development;Dopamine;Dopamine D2 Receptor;dopamine replacement therapy;Dose;Dose Limiting;DRD4 gene;Drug Kinetics;Drug Targeting;effective therapy;Evaluation;Exclusion;Experimental Models;experimental study;Ganglia;Globus Pallidus;Glutamate Receptor;Grant;Hypokinesia;improved;In Vitro;in vivo;in vivo evaluation;L-DOPA induced dyskinesia;Lead;lead optimization;Levodopa;Ligands;Medical;Metabolic;Modeling;Motor;motor symptom;mouse model;MPTP Poisoning;Mus;Muscle Rigidity;Neurodegenerative Disorders;Neurons;neuropsychiatry;nonhuman primate;novel;novel therapeutic intervention;Output;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Patients;Penetration;Performance;Permeability;Pharmaceutical Chemistry;Pharmacological Treatment;Plasma;Plasma Proteins;Play;Pre-Clinical Model;prevent;Property;Protein Isoforms;psychotic;pyridine;Reaction;receptor;Rest Tremor;Rodent Model;Role;scaffold;Series;Serotonin;serotonin receptor;Severities;sigma-1 receptor;Solubility;standard care;Stereotyping;Substantia nigra structure;Testing;Therapeutic;Therapeutic Agents;Toxicology;Treatment Efficacy;Work

PROJECT_TITLE: Discovery and characterization of selective D4R antagonists and their evaluation in preclinical models of PD-LIDs

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPT OF AGRIC/CONSUM SRVCS

ORG_STATE: FL

PHR: E. Sample Analysis Commitment: (1) The laboratory is estimating to test 1-2 samples per week, eight samples a month, up to 100  samples a year regarding antimicrobial resistance monitoring. BADDL is anticipating  performing 10 case investigations per year. The case investigation may include collecting  history, gross necropsy, histopathology, bacterial isolation and identification,  Antimicrobial Susceptibility Testing (AST) and toxicology (sent to an outside laboratory).  The reference procedures and standard operating procedures are documented and  controlled and will be used for the laboratory testing procedures. Results will be  documented on the controlled laboratory worksheet and will be released via Laboratory  Information Management System (LIMS). Case coordination will be done by the section  head(s) or the bioscientists. As resources permit BADDL would like to participate in  sequencing the isolates. (2) BADDL has the ability and willingness to perform data entry into eLEXNET or Securesheet. F. Laboratory Expertise: (1) BADDL has been participating as a source lab for the Vet-LIRN whole genome sequencing  project by isolating, identifying and performing antimicrobial susceptibility testing on  Staphylococcus pseudintermedius, Escherichia. Coli, Klebsiella pneumoniae from dogs  and Salmonella enterica, Campylobacter from various animal sources and sends these  isolates to the regional laboratory for genome sequencing. The data is then entered through  a metadata sheet. (2) BADDL has also participated in a Campylobacter jejuni enriched culture and direct PCR  method. In this project, four analysts tested canine fecal samples for isolation and  molecular characterization. All four analysts participated and successfully completed and  passed the training tests both for culture and PCR. (3) BADDL also participating aquaculture isolates monitoring (Edwardsiella, Vibrio,  Photobacterium, Lactococcus and Aeromonas) G. Equipment: (1) A detailed description of equipment has been provided in an earlier section and  photographs have been attached. (2) The Nephlometer and Auto-inoculator for the Sensititre has been provided by Vet-LIRN.

PI_NAMEs: BOMMINENI, Y. REDDY  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Vet-LIRN Cooperative Agreement for Investigating Microbial, Chemical/Drug Contamination Events and Animal Feed-related Outbreaks


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MURRAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MURRAY STATE UNIVERSITY

ORG_STATE: KY

PHR: Project Narrative CVM Vet-LiRN Veterinary Diagnostic Laboratory Program (U18) PAR-22-063  Breathitt Veterinary Center (BVC) will utilize funding from this program to improve the quality of testing by staff members through proficiency testing and staff training. Funding will also support the Antimicrobial Resistance Study being conducted at BVC in collaboration with other labs in the Vet-LiRN network and provide a maintenance contract for the SensiTitre instrument.

PI_NAMEs: REED, DEBBIE CAROL (contact)

PROJECT_TITLE: Equipment Purchases for Breathitt Veterinary Center


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Diabetes;Neurosciences;Nutrition;Sleep Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: PROJECT NARRATIVE Normal blood pressure has a regular circadian rhythm, which is disrupted in up to 75% of diabetic patients and associates with detrimental cardiovascular outcomes. Using a glucagon-like-peptide-1 receptor agonist (GLP- 1RA), an FDA approved anti-diabetic drug, we found that it protects blood pressure circadian rhythm in diabetic mice only when administered during their resting time. This proposal will investigate mechanisms of this protective effect in diabetic mice for the future potential of GLP-1RA as a chronomedicine that corrects disrupted blood pressure circadian rhythm in diabetic patients.

PI_NAMEs: GONG, MING C (contact);GUO, ZHENHENG

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Agonist;Animals;Anti-diabetic Drugs;ARNTL gene;Bilateral;Blood Pressure;blood pressure reduction;Body Weight;Brain;cardiovascular risk factor;Cardiovascular system;Chronic Disease;Chronotherapy;Circadian Rhythms;Clinical Trials;comorbidity;cost;Darkness;Data;db/db mouse;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Duodenum;Eating;effective therapy;exenatide;Fatty acid glycerol esters;FDA approved;feeding;Female;Foundations;Future;Genes;GLP-I receptor;Glycosylated hemoglobin A;Goals;gut-brain axis;High Fat Diet;Hippocampus;Hypertension;Hypothalamic structure;improved;Knock-out;Knockout Mice;Knowledge;Light;Link;liraglutide;Literature;male;Mediating;Messenger RNA;Metabolism;Mus;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Phase;pre-clinical;prevent;Prognosis;protective effect;Publications;Regimen;Rest;Risk Factors;Role;Scheme;sex;sexual dimorphism;Sympathetic Nervous System;targeted treatment;Time;Time-restricted feeding;Type 2 diabetic;Vagotomy;Vagus nerve structure

PROJECT_TITLE: Targeting GLP-1 receptor as a new chronotherapy against nondipping blood pressure in diabetes

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: The proper temporal and spatial regulation of chromatin is key in human development and health, and dysregulation leads to diseases such as diabetes, cancer, heart disease, and developmental, neurological, and immunological disorders. The proposed research project will further our understanding of the molecular mechanisms that alter the structure and accessibility of chromatin. These studies will contribute to fundamental knowledge about mechanisms of gene regulation and how dysregulation leads to disease states.

PI_NAMEs: MORRISON, EMMA ANTONINA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acylation;Binding;biophysical techniques;Centromere;Chemicals;Chromatin;Chromatin Structure;Chromosomal Stability;Complex;Core Protein;developmental disease;Diabetes Mellitus;Disease;DNA;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genetic;Goals;Health;Heart Diseases;histone modification;Histones;Human Development;human disease;Immune System Diseases;Knowledge;Laboratories;Language;Link;Lysine;Malignant Neoplasms;Metabolic;Metabolic Diseases;Mitosis;Molecular;Molecular Conformation;Nervous System Disorder;NMR Spectroscopy;Nucleosomes;Phase;Post-Translational Protein Processing;Regulation;Research Project Grants;Role;Structure;System;Tail;Translating;Variant

PROJECT_TITLE: The role of histone tails in chromatin structure and gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Narrative: The goal of the proposed studies is to better understand the mechanims underlying hypofrontality development and consequent cognitive defiicts in neuropsychiatric disorders, more specifically in response to drug exposure. Since we found that chronic mephamphetamine (METH) exposure increases perineuronal nets (PNNs) in the prefrontal cortex, known to enhance parvalbumin positive fast spiking interneurons, this study will investigate the role of PNNs in METH-induced hypofrontality. The knowledge generated by this proposal may provide new pharmacotherapeutics targets for multiple disorders with hypofrontality-related symptoms.

PI_NAMEs: LAVIN, ANTONIETA  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Address;Attentional deficit;Behavior;Behavioral;Brain;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive disability;Data;Dendrites;density;Development;Digestion;disability;Disease;Drug Addiction;Drug Exposure;Drug Stability;effective therapy;executive function;experience;experimental study;Exposure to;Extracellular Matrix;frontal lobe;Glycoproteins;Goals;hippocampal pyramidal neuron;Human;Hyperactivity;Impulsivity;Individual;innovation;insight;Interneurons;Investigation;Ion Channel;Knowledge;Label;Link;Literature;Medial;Memory;Memory impairment;Mental Depression;Methamphetamine;Methamphetamine dependence;methamphetamine exposure;Modeling;neuronal cell body;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;Parvalbumins;Pathologic;Prefrontal Cortex;Quality of life;Rattus;Regulation;relapse risk;Research;response;Role;Self Administration;Short-Term Memory;Substance Use Disorder;Symptoms;Synapses;Synaptic plasticity;Synaptic Receptors;Techniques;Testing;Time;transmission process;Viral;Whole-Cell Recordings

PROJECT_TITLE: Role of Perineuronal Nets in Methamphetamine-Induced Hypofrontality and Cognitive Deficits

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Project Narrative: Over nearly a decade, Project South East Area Maritime Industry Safety Training (SEAMIST), a Hazardous Waste Worker Training Program (HWWTP) and Project Hazardous Material Maritime Industry Response Training Initiative (HazMIRTSI), a Hazmat Preparedness Disaster Training Program (HPDTP), funded by a cooperative agreement with the National Institute of Environmental Health Sciences (NIEHS) has made inroads in addressing the unmet need of hazardous materials safety and disaster response preparedness training, tailored specifically for the maritime industry. The need still remains to continue to build and expand upon the training provided by Projects SEAMIST and HazMIRTSI, which is imperative for improving the safety of those who work directly and indirectly with hazardous materials in and out of the various ports and waterways and those skilled response personnel and community volunteers responding to disasters. Through our continued effort to facilitate maritime industry specific safety training, it is our goal to train approximately 13,000 workers and volunteers throughout the contiguous United States over the next five years.

PI_NAMEs: COHEN, DARREN  (contact)

PROGRAM_OFFICER_NAME: PEARSON, AMELIA JACKSON

PROJECT_TERMS: Accidents;Address;Adult;Affect;Alabama;Area;California;Cessation of life;Communities;community involvement;Community Outreach;Connecticut;Country;curriculum enhancement;Delaware;Development;Disasters;Educational Curriculum;emergency service responder;Employee;Ensure;Evaluation;Event;Exposure to;first responder;flexibility;Florida;Funding;Future;General Population;Goals;hazard;Hazardous Substances;Hazardous Waste;Health;Hour;Human Resources;improved;Incidence;Individual;Industry;Injury;innovation;Language;Learning;Louisiana;Maine;Massachusetts;meetings;member;Mississippi;National Institute of Environmental Health Sciences;New Jersey;New York;Occupational;Occupations;Participant;Peer Review;Pennsylvania;Persons;Population;prevent;programs;Protocols documentation;Readiness;response;Rhode Island;Safety;skills;skills training;South Carolina;Spanish/English;Target Populations;Techniques;Technology;Texas;Trainers Training;Training;Training Programs;training project;U-Series Cooperative Agreements;United States;Virginia;volunteer;Water;Work;worker safety

PROJECT_TITLE: Project SEAMIST (South East Area Maritime Industry Safety Training)


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Accidents;Acetates;Address;Adult;Air;Alabama;American;Ammonia;Area;Awareness;California;Cessation of life;Communicable Diseases;Communities;Country;Critical Thinking;curriculum enhancement;Dangerousness;Docking;Education;Educational Curriculum;Educational process of instructing;Employee;English Language;Ensure;Evaluation;Event;Exposure to;Feedback;Florida;Funding;Geographic Locations;Goals;Guidelines;Hand functions;hazard;Hazardous Substances;Hazardous Waste;Health;health training;Hour;Human Resources;Incidence;Individual;Industry;injured;Injury;innovation;instructor;International;International Aspects;Knowledge;Language;Learning;Louisiana;Marketing;Measures;Methods;Mississippi;Modification;National Institute of Environmental Health Sciences;Nature;New York;Occupational;Occupational Exposure;Occupations;opioid use;Participant;Peer Review;Persons;Population;prevent;Program Evaluation;programs;Protocols documentation;Readiness;Risk Reduction;Safety;Sea;skills;South Carolina;Spanish;Spanish/English;Steel;Stress;Students;Target Populations;Technology;Texas;Time;tool;Training;training opportunity;Training Programs;Transportation;U-Series Cooperative Agreements;United States;Virginia;Water;Work;worker safety;Workplace


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Emergency Care;Prevention

PROJECT_TERMS: Academy;Accidents;Address;Adult;Advisory Committees;Area;Cessation of life;Coast Guard;college;Communities;community involvement;Community Outreach;Connecticut;Critical Thinking;curriculum enhancement;Delaware;Disaster Planning;Disasters;Education;Educational Curriculum;Educational process of instructing;Emergency Medicine;emergency preparedness;Emergency response;emergency service responder;Emergency Situation;Ensure;Environment;Evaluation;Event;experience;Exposure to;Feedback;Fire - disasters;first responder;Floods;Florida;Funding;Goals;Hand functions;hazard;Hazard Management;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;Health Personnel;Human Resources;Hurricane;Incidence;Individual;Industry;Injury;innovation;instructor;International;Knowledge;Learning;Maine;Massachusetts;Measures;member;Methods;Modification;Molds;mortality;National Institute of Environmental Health Sciences;Natural Disasters;New England;New Jersey;Occupations;Osteopathic Medicine;Pennsylvania;prevent;Procedures;Process;Program Evaluation;programs;Protocols documentation;Qualifying;Readiness;Recovery;Resources;response;Rhode Island;Risk;Safety;Sea;Services;Ships;skills;Students;Technology;Terrorism;Time;tool;Trainers Training;Training;training opportunity;Training Programs;U-Series Cooperative Agreements;United States;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;virtual reality;volunteer;Vulnerable Populations;worker safety

PROJECT_TITLE: Hazardous Material Maritime Industry Response Training Safety Initiative (HazMIRTSI)


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

PHR: PROJECT NARRATIVE New long-acting HIV prevention methods, including the dapivirine vaginal ring (DVR) and cabotegravir (CAB) injections, will be key to ending the HIV epidemic; however, acute HIV infections (AHI) can occur during DVR or CAB use from inadequate adherence/exposure or resistance to the prevention agent. This study will use advanced laboratory methods to identify why HIV infections occur among persons using CAB and DVR in the United States and Kenya and assess treatment outcomes 12 months after AHI. This study aims to improve individual outcomes and benefit population health by informing strategies to reduce future infections among persons using DVR and CAB, reduce the risk of resistance to HIV treatment if infection occurs, and improve the success of HIV treatment, in order to optimize the use of long-acting HIV prevention modalities.

PI_NAMEs: KOSS, CATHERINE ANNE STIMETS (contact);PARIKH, URVI M.

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Acceleration;Acute;acute infection;Address;Adherence;Africa South of the Sahara;AIDS prevention;Anti-Retroviral Agents;Anti-retroviral resistance;antiretroviral therapy;Behavior;Behavior assessment;Behavioral;Clinical;Dapivirine;Data;Diagnosis;Diagnostic;Drug Kinetics;Drug resistance;drug testing;Enrollment;Epidemic;Failure;FDA approved;Future;genome sequencing;Hair;Health;HIV;HIV diagnosis;HIV Infections;implementation strategy;improved;Incidence;Individual;Infection;Injectable;Injections;innovation;Interview;Kenya;Knowledge;Laboratories;Lead;Measures;Methods;Modality;Mutation;next generation;next generation sequencing;novel;Oral;Outcome;Outcome Assessment;Participant;Persons;Pharmaceutical Preparations;Phenotype;Plasma;population health;Population Study;pre-exposure prophylaxis;Prevention;programs;Public Health;Recording of previous events;Regimen;Research Personnel;Resistance;resistance mutation;Risk;Risk Reduction;sample collection;Sampling;Sapphire;scale up;Services;success;Surveys;Tail;Testing;therapy adherence;therapy outcome;Time;Treatment outcome;United States;Vaginal Ring;Viral;Viremia;Virus;whole genome;Woman

PROJECT_TITLE: ACTION: Study of ACuTe Infections On Novel HIV Prevention Modalities


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: ENDOCRINE SOCIETY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Chronic, endocrine disorders such as diabetes, disproportionately impact racial and ethnic minority communities, yet these same populations are grossly underrepresented among the professionals that study and treat these prevalent conditions. Professional development efforts such as the Future Leaders Advancing Research in Endocrinology (FLARE) Program will enhance the recruitment and retention of minority trainees within the biomedical and clinical workforce and prepare them to advance as productive leaders within the scientific community. A strong mentorship component to the Program aims to further decrease health disparities by allowing these individuals to become inspirational role models for future generations of diverse biomedical and clinical professionals.

PI_NAMEs: ABEL, E DALE (contact);JOSEPH, JOSHUA J

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academia;Address;African American population;Alaska Native;American;Association of American Medical Colleges;Biological Sciences;Biomedical Research;biomedical scientist;Black American;Budgets;career;career development;Career Mobility;Censuses;Chronic;Clinical;clinical care;Clinical Research;Collaborations;Communication;Communities;Credentialing;Data;Dedications;Development;Diabetes Mellitus;Disparity;Education;Educational Activities;Educational workshop;Effectiveness;Eligibility Determination;Endocrine;Endocrine System Diseases;Endocrinologist;Endocrinology;Engineering;Ensure;Ethics;ethnic minority;Evaluation;experience;Faculty;Fellowship Program;Fostering;Future;Future Generations;General Population;Goals;Government;Grant;Growth;Health;health equity;Hispanic;Hispanic Americans;Home;Human Resources;improved;Individual;Industry;Infrastructure;Institution;Intention;Internships;Journals;Knowledge;Latino;Latinx;Leadership;leadership development;Learning;Medicine;meetings;member;Mentors;Mentorship;Minority;minority communities;Minority Graduate Student;Minority Health Research;minority investigator;minority trainee;Minority-Serving Institution;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;neighborhood disadvantage;online community;online resource;Organizational Objectives;Outcome;outreach;Pacific Islander;Peer Review;Population;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;Professional Organizations;programs;racial minority;Readiness;recruit;Reduce health disparities;Reporting;Research;research and development;Research Institute;Research Personnel;Role;role model;Science;scientific organization;Scientist;Services;skills;skills training;Societies;statistics;Strategic Planning;student participation;success;summer research;symposium;Technology Transfer;Training;Training Programs;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Visit

PROJECT_TITLE: Future Leaders Advancing Research in Endocrinology (FLARE): Professional Development for Underrepresented Trainees and Junior Faculty


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE - OVERALL The aging process plays a key role in the development of chronic disease and disability. The goal of our program is to understand the biology of aging and develop new interventions to promote healthy aging.

PI_NAMEs: HORNSBY, PETER J;SALMON, ADAM  (contact);STRONG, RANDY

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;age related;Aging;aging mechanism;aging process;American;Animal Model;Applied Genetics;Autopsy;Awareness;Biochemical;Biological Assay;Biology of Aging;Callithrix;Capital;Capsicum;career development;Chronic disability;Chronic Disease;clinical center;Data Analyses;design;Development;Dietary Administration;Drug Delivery Systems;Drug Evaluation;Drug Targeting;Education;Elderly;end of life;Environment;experience;Experimental Designs;Fostering;Foundations;Funding;Genetic;Geroscience;Goals;Grant;healthspan;healthy aging;Individual;innovation;Institution;interest;Intervention;Knockout Mice;Knowledge;Leadership;Life Expectancy;life span;Longevity;Measures;Methodology;Modeling;Mole Rats;Molecular;Molecular Analysis;Molecular Biology;Monitor;Mus;nonhuman primate;novel;novel strategies;Nutraceutical;Organ;Pathologic;Pathology;Pathway interactions;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Phenotype;Physiology;Play;programs;Rattus;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Scientist;Services;Shock;Site;square foot;Statistical Data Interpretation;success;Testing;Tissues;tool;Training;Training Activity;Training and Education;Training Programs;Transgenic Organisms;Vertebrates;Whole Organism;Work

PROJECT_TITLE: San Antonio Nathan Shock Center of Excellence in the Biology of Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: HORNSBY, PETER J (contact)

PROJECT_TERMS: Aging;Agreement;Animals;Area;Award;Biology of Aging;career;career development;Career Mobility;Charge;Collaborations;Communities;Country;Development;Environment;Extramural Activities;Faculty;Fee-for-Service Plans;Funding;Funding Mechanisms;Geroscience;Goals;Grant;Health Services Accessibility;Home;Individual;innovation;Institution;Investments;Leadership;meetings;member;Mentors;next generation;novel;Paper;Pathology;Peer Review;Pharmacology;Physiology;Pilot Projects;Play;Productivity;programs;Publications;Publishing;Qualifying;Recommendation;Records;recruit;Research;Research Activity;research and development;Research Personnel;Research Support;Resources;Role;Scientist;senior faculty;service programs;Services;Shock;success;Universities;Work

PROJECT_TITLE: Research Development Core


PI_NAMEs: STRONG, RANDY  (contact)

PROJECT_TITLE: Administrative/Program Enrichment Core


PI_NAMEs: NELSON, JAMES FLOYD (contact)

PROJECT_TERMS: Address;Adrenal Gland Hyperfunction;Age;age effect;age-related disease;Aging;aging mechanism;aging process;aging related;Animal Experimentation;Animal Model;Animals;Applications Grants;Autophagocytosis;biogerontology;Biological;Biology;Biology of Aging;Breeding;Callithrix;Callithrix jacchus jacchus;Caloric Restriction;Cells;Consultations;Continuity of Patient Care;cost effective;Data;Data Analyses;Data Collection;design;Development;dietary;Disease;Dissection;Documentation;Education;extend lifespan;Four Core Genotypes;Funding;Gender;Generations;genotypic sex;Goals;Health;healthspan;healthy aging;human female;in vivo;Inflammation;innovation;Institution;interest;Intervention;Intervention Studies;Kidney;Knowledge;Leadership;life history;life span;Longevity;Maintenance;Mammals;Manuscripts;Measurable;Measures;Mission;Modeling;Mole Rats;Molecular;Monitor;mouse model;Mus;nerve stem cell;nonhuman primate;novel;Nutritional;Pathologic;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiological;Play;Preparation;programs;protective effect;Publications;Rattus;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;Rodent;Rodent Model;Role;Sampling;Services;sex;Sex Differences;sexual dimorphism;Shock;Skeletal Muscle;sound;Study models;Tissues;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Aging Animal Models and Longevity Assessment Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Physical Activity;Prevention

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative The proposed research is relevant to public health because it will identify how aging and exercise impacts signaling from adipose tissue laced between and within skeletal muscle to alter the risk of type 2 diabetes and the loss of muscle mass and strength. These findings will likely provide new therapeutic targets to prevent the age-induced risk of type 2 diabetes and loss of muscle mass and strength. Thus, the proposed research is relevant to the NIH’s mission to enhance health, lengthen life and reduce illness and disability.

PI_NAMEs: BERGMAN, BRYAN C (contact);WALSH, MARTIN JOHN

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Achievement;Address;Adipocytes;adipokines;Adipose tissue;Age;age effect;Aging;Agonist;Ancillary Study;Attenuated;Bathing;Biological;Cell Nucleus;Cells;Clinical;clinical center;Colorado;combat;Data;Development;Diabetes Mellitus;Diameter;disability;Exercise;exercise training;experimental study;Extracellular Matrix Proteins;Fibroblasts;Fibronectins;Florida;Freezing;Fresh Tissue;GDF8 gene;Health;improved;In Vitro;Individual;innovation;Insulin Resistance;insulin sensitivity;Intervention;Knowledge;Life;Lymphocyte;Marble;Measures;Metabolic;Metabolic dysfunction;Mission;Molecular;Muscle;Muscle Fibers;muscle form;muscle metabolism;muscle strength;Muscular Atrophy;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;older adult;Older Population;Outcome;Paracrine Communication;Parents;Pathogenesis;Physical activity;Play;Positioning Attribute;prevent;Property;Public Health;Research;resistance exercise;Risk;Role;Sampling;sarcopenia;Signal Transduction;Signaling Molecule;Site;Skeletal Muscle;subcutaneous;Testing;therapy development;transcriptome sequencing;Transducers;Type II Activin Receptors;United States National Institutes of Health

PROJECT_TITLE: Effects of aging and exercise training on intermuscular adipose tissue (IMAT) in MoTrPAC

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Aging;Neurosciences

PI_NAMEs: HAN, XIANLIN  (contact)

PROJECT_TERMS: Address;age related;Age related pathologies;Aging;aging related;Alzheimer's Disease;Animal Model;Applications Grants;Award;Bioenergetics;Biological Assay;Biology of Aging;Biometry;Brain;Callithrix;Callithrix jacchus jacchus;Cardiolipins;Cell Aging;Cells;Charge;Cognitive;Competence;Complex;Consultations;cost effective;Data;Data Analyses;design;Development;Enzymes;Etiology;Evaluation;Experimental Designs;Foundations;FRAP1 gene;Funding;Future;Goals;Growth;healthspan;heart function;Hematology;Human;Individual;innovation;Institution;insulin sensitivity;interest;Intervention Studies;Investments;Knowledge;Laboratories;life span;Link;lipid metabolism;lipidomics;Long-Term Effects;Longevity;Measures;member;Metabolism;Mission;mitochondrial dysfunction;Modeling;Molecular;molecular phenotype;Monitor;mTOR inhibition;Muscle;neuromuscular function;novel;Online Systems;operation;Organ;Pathogenesis;Pathologic;Pathology;pharmacologic;Pharmacology;Phase;Phenotype;Physiological;Physiology;process improvement;programs;Publications;Research Design;Research Methodology;Research Personnel;resilience;Resources;Rodent;Role;Scientist;Services;Shock;Signal Transduction;Sirolimus;System;Technology;Testing;Tissues;tool;Training;Training and Education;Vascular Dementia;Whole Organism;Work

PROJECT_TITLE: Integrated Physiology of Aging Core (IPAC)


NIH_SPENDING_CATS: Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Multiple organ dysfunction (MODS) is a leading cause of death and disability after trauma. The mechanisms promoting MODS after trauma are largely unknown but are believed to involve excessive activation of the immune system as well as the formation of small blood clots in organs such as the lungs and kidneys. This program will 1) examine how trauma-induced MODS occurs with particular emphasis on how platelets regulate immune function and thrombosis 2) characterize immune and inflammatory consequences of modern trauma resuscitation and 3) design targeted assays to reduce MODS and target platelet dysfunction.

PI_NAMEs: NEAL, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Automobile Driving;Biological Assay;Blood coagulation;Blood Platelets;Blood Transfusion;Blood Vessels;Cause of Death;Cells;Coagulation Process;Critical Illness;Data;Defect;design;disability;Endothelium;Event;Functional disorder;Goals;Immune;immune activation;immune function;Immune system;immunothrombosis;improved;Inflammation;Inflammatory;Injury;Innate Immune Response;Intervention;Kidney;Knowledge;Link;Lung;Modernization;Morbidity - disease rate;mortality;Multiple Organ Failure;Organ;organ injury;Patients;Phase;platelet function;post intervention;Prevention;programs;Research;Resuscitation;Risk;Role;Sentinel;Survivors;targeted treatment;Techniques;Thrombosis;thrombotic;Tranexamic Acid;Trauma;trauma induced coagulopathy;Trauma patient;Whole Blood;Work

PROJECT_TITLE: Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: THEIA IMAGING LLC

PHR: NARRATIVE  Handheld OCT can be used to screen for and diagnose eye disease in infants, young children and many patients in intensive care or with certain disabilities, who are unable to cooperate for conventional tabletop imaging and are unable to communicate about loss or disturbance of vision, making it difficult to diagnosis vision- threatening diseases before irrevocablevision loss occurs. Because adoption of handheld OCT has beenlimited, largely due to poor usability of existing commercial devices, Theia Imaging is pursuing commercialization of a high-speed, portable, user-friendly, hand-held OCT system for use in this population. The commercialization of the Theia system will substantially improve the health care of patients who are currently underserved by existing OCT devices.

PI_NAMEs: DHALLA, AL-HAFEEZ ZAHIR;VIEHLAND, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Adoption;Adult;Age related macular degeneration;Anesthesia procedures;arm;awake;Blindness;Caring;Child;Classification;Clinical;commercialization;Communication;Computer software;Computers;cost;Custom;Data;design;Development;Devices;Diabetic Retinopathy;Diagnosis;diagnosis standard;disability;Disease;disease diagnosis;ergonomics;Examination Under Anesthesia;Exclusion;Eye;Eye diseases;Feedback;Goals;Head;Healthcare;Human;Image;imager;imaging modality;improved;Industrialization;Infant;Infant Care;Injections;insight;Intensive Care;International;light weight;manufacture;Medical Device;Molds;Monitor;Nerve;Newborn Infant;non-invasive imaging;Optic Disk;optic nerve disorder;Optical Coherence Tomography;optical imaging;Outcome;Pathway interactions;Patient Care;Patients;Phase;physically handicapped;Pilot Projects;point of care;Point-of-Care Systems;Population;portability;Positioning Attribute;Premature Infant;Production;programs;prototype;Pupil;quality assurance;Refractive Errors;Reporting;Research;Research Personnel;Rest;Retina;Retinal Diseases;retinal imaging;Retinopathy of Prematurity;Risk;sample fixation;School-Age Population;screening;Side;Small Business Innovation Research Grant;Speed;standard of care;stem;System;Time;Training;Translations;United States National Institutes of Health;usability;user-friendly;Vision;Visual impairment;Visualization;Weight

PROJECT_TITLE: A High-Speed, User-Friendly, Handheld OCT System for Patients who are Unable to Cooperate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: IKENO, YUJI  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Age;age related;Aging;aging related disease;Animal Model;animal old age;Animals;Applications Grants;Archives;Biochemical;Biological;Biology of Aging;Brain;burden of illness;Cause of Death;Cells;Cellular biology;Cellular Metabolic Process;Cellular Morphology;Cessation of life;Characteristics;Communication;Communities;comorbidity;Country;Data;Data Analyses;Databases;Development;Disease;end of life;experimental study;Faculty;Freezing;Frozen Sections;Funding;Funding Agency;Genetic;Gliosis;Glomerulonephritis;Grant;healthspan;Histologic;histological slides;histological stains;Histology;Histopathology;human old age (65+);Image;Incidence;Infiltration;Inflammation;insight;Intervention;juvenile animal;laser capture microdissection;Lesion;Life;life span;Longevity;Macrophage;Manuscripts;Medicine;middle age;Modeling;Molecular;Molecular Analysis;Morphology;Mus;Nature;neoplastic;nonhuman primate;Organ;Paper;Paraffin;Paraffin Embedding;Pathogenesis;Pathologic;Pathology;pharmacologic;Preparation;Prevalence;Probability;Publications;Rattus;Research;Research Personnel;Resources;Rodent;Rodent Model;Scientist;senescent cell;Services;Severities;Shock;Slide;Stains;Time;tissue archive;Tissue Microarray;tissue preparation;Tissues;trend analysis;Tumor Burden

PROJECT_TITLE: Pathology Core


PI_NAMEs: GINSBURG, BRETT C (contact)

PROJECT_TERMS: absorption;Address;age-related disease;Aging;aging related;Animal Feed;Animal Model;Animals;Area;assay development;Biological Assay;Biology of Aging;Blood;Blood specimen;Callithrix;Collection;Consultations;cost;Data Analyses;data sharing;design;Development;Dosage Forms;Dose;Drug Evaluation;Drug Kinetics;Drug Stability;Drug Targeting;Drug usage;Dryness;Education;experience;Experimental Designs;experimental study;flexibility;Functional disorder;Funding;gastrointestinal;Gene Modified;Glucose;Goals;Grant;healthspan;High Pressure Liquid Chromatography;Human;Income;inhibitor;innovation;Institution;Intervention;Investigation;Laboratories;Laboratory Animal Models;Laboratory Animals;life span;Manuscripts;Measurement;Measures;Methods;Modeling;mTOR Inhibitor;Mus;novel therapeutics;Outcome;Paper;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Plasma;Preparation;Procedures;Process;Productivity;Rattus;Recommendation;Research;Research Personnel;Rodent;senolytics;senomorphic;Services;Shock;Signal Pathway;Sirtuins;small molecule;Solid;Spottings;System;Tail;Testing;Time;Tissues;tool;Urine;usability;Work;Writing

PROJECT_TITLE: Analytical Pharmacology and Drug Evaluation Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Natural Products;Neurosciences;Pediatric;Pregnancy;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Cannabis use has increased in pregnant women and teens. Expanding knowledge about the impact of developmental cannabis exposure on specific neurobiological events causally linked to behavioral disturbances later in life will provide significant insights about neurobiological mechanisms that underlie the vulnerability to neuropsychiatric disorders.

PI_NAMEs: HURD, YASMIN L. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Adolescent;Adult;Amygdaloid structure;Animal Model;Anxiety;Astrocytes;Attention;Behavior;Behavioral;behavioral phenotyping;behavioral study;Bioinformatics;Biological;Brain;Cannabidiol;Cannabis;Cells;Characteristics;Child;Child Behavior;Childhood;Collection;Complement;cytokine;Data;Data Set;Databases;Decision Making;Dedications;Development;differential expression;Early identification;endogenous cannabinoid system;endophenotype;Epigenetic Process;Evaluation;Event;experience;Exposure to;Female;Female of child bearing age;Future;Gene Expression;Gene Expression Profiling;gene network;Gene Proteins;Genes;Genetic Transcription;Growth;Health;Homing Behavior;Human;human fetal brain;human model;human subject;Immune;immune function;Immune system;immunoregulation;infancy;Inflammatory;insight;Knowledge;knowledge translation;late life;Life;Link;Long-Term Effects;male;marijuana legalization;marijuana use;marijuana use in pregnancy;maternal marijuana use;Mediating;Medical;Minority Groups;Modeling;Modification;Molecular;Molecular Profiling;Motivation;multidisciplinary;multiple omics;negative affect;neurobiological mechanism;Neurobiology;neurodevelopment;Neuroglia;Neurons;neuropsychiatric disorder;novel;Nuclear RNA;Nucleus Accumbens;Outcome;Pharmaceutical Preparations;Placenta;Play;Policies;Politics;Population;postnatal;Pregnancy;pregnant teen;Pregnant Women;prenatal;prenatal exposure;Process;programs;Proteins;Proteome;Proteomics;Psychopathology;public education;Rattus;Regulation;Research;Resolution;Rewards;Risk;risk perception;Rodent;Rodent Model;Role;Specimen;Stress;Structure;substance use treatment;Synapses;synaptic function;Synaptic plasticity;Tetrahydrocannabinol;THC exposure;Time;transcription factor;transcriptome;transcriptome sequencing;translational study;United States;Viral;virtual;Vulnerable Populations;Woman;Youth

PROJECT_TITLE: Molecular underpinnings of the developmental Effects of Cannabis

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE It is imperative to develop meaningful and reliable biomarkers capable of identifying eyes at risk for developing vision loss from advanced age-related macular degeneration (AMD), especially if future treatments are to be given prior to vision loss. We will develop advanced analytic methods and apply them to our high-resolution optical coherence tomography angiography (OCTA) prototype that will overcome current limitations for imaging the retinal deep capillary plexus and the choriocapillaris, the two circulatory systems implicated in AMD pathogenesis. OCTA is safe and non-invasive and it is an ideal platform to generate novel AMD biomarkers in addition to assisting clinicians with AMD diagnosis and management decisions.

PI_NAMEs: BAILEY, STEVEN T;JIA, YALI  (contact)

PROJECT_TERMS: advanced analytics;Affect;Age related macular degeneration;Age Years;Algorithms;analytical method;analytical tool;Anatomy;Angiography;Architecture;Area;Artificial Intelligence;attenuation;Biological Markers;Blindness;Blood capillaries;Blood flow;Blood Vessels;Cardiovascular system;Characteristics;choroidal circulation;Choroidal Neovascularization;Clinical Research;Compensation;Computational algorithm;Cross-Sectional Studies;deep learning;Defect;density;Detection;Development;Devices;Diagnosis;Disease Progression;Drusen;Elderly;Evaluation;Exudate;Exudative age-related macular degeneration;Eye;Eye diseases;feature extraction;Future;geographic atrophy;geographic risk;Goals;Grant;high risk;Image;improved;innovation;interest;Lateral;Length;Lobular;Location;Longitudinal Studies;macula;Measurement;Measures;Methods;Monitor;Morphologic artifacts;Noise;Nonexudative age-related macular degeneration;novel;novel marker;Optical Coherence Tomography;Pathogenesis;Perfusion;Persons;Photoreceptors;prevent;prototype;reconstruction;Resolution;Retina;retina blood vessel structure;retina circulation;retinal imaging;Risk;Risk Factors;Role;Sampling;Scanning;Sensitivity and Specificity;Series;Signal Transduction;Source;Speed;Structure of retinal pigment epithelium;success;System;Technology;Testing;Time;treatment response;Vascular Endothelial Growth Factors;Vision;Visualization;Work

PROJECT_TITLE: OCT Angiography for Age-related Macular Degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Higher levels of physical activity have been demonstrated to improve health across a wide range of contexts and reduce cognitive decline as adults become older, but more than half of all adults in the United States do not meet their physical activity goals. One type of physical activity that is broadly applicable to people of all ages is walking. This study will use a Hybrid Type 1 effectiveness-implementation design to adapt, and test the effectiveness of two successful social incentive-based interventions, a gamification strategy and financial incentives donated to charity on the participant's behalf, to increase physical activity among 225 low-income, mostly minority families in community settings.

PI_NAMEs: GLANZ, KAREN  (contact);GREYSEN, SCOTT RYAN

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Adoption;Adult;Age;arm;Behavior;behavioral economics;Body Weight decreased;Cardiovascular Diseases;Charities;Cluster randomized trial;Communities;community collaboration;community engagement;community organizations;community partners;community setting;comparison control;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost comparison;cost-effectiveness ratio;Data;Decision Making;Dementia;design;Diabetes Mellitus;Dissemination and Implementation;Economics;effectiveness evaluation;effectiveness measure;effectiveness testing;effectiveness trial;effectiveness/implementation design;effectiveness/implementation study;Elderly;Equipment;Family;financial incentive;follow-up;Goals;Health;Health Benefit;health disparity;Hybrids;Hypertension;Impaired cognition;implementation intervention;implementation process;improved;incentive strategies;incentive-based intervention;Incentives;Individual;Intervention;Intervention Studies;Low income;Measurable;medication compliance;Mental Depression;Mental Health;Methods;Minority;mortality;Neighborhoods;Obesity;older adult;Participant;Pattern;Persons;Phase;Physical activity;Procedures;process evaluation;programs;Psychology;Public Health Practice;Reaction;Recommendation;Reduce health disparities;Research Design;Risk;scale up;Science;smoking cessation;social;Social Network;Testing;Time;tool;Training;treatment arm;United States;Walking;Work

PROJECT_TITLE: A Hybrid Type 1 Effectiveness-Implementation Study of Social Incentives Strategies to Increase Physical Activity

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Congenital Structural Anomalies;Genetics;Orphan Drug;Osteoporosis;Pediatric;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE While compelling evidence shows that bone loss and fragility with age and osteoporosis result from corrupted coupling between osteoclastic bone resorption or osteoblastic bone formation, the precise mechanism of osteoclast-osteoblast communication remains unclear. Here we propose to determine the cell-type specific mechanism of coupling and identify molecular candidates expressed by these cell types using human and mouse models of autosomal dominant osteopetrosis type II (ADOII), a rare inheritable osteopetrosis characterized by high skeletal bone mass and also increased fragility, as our preliminary data suggest that this bone phenotype results from pathologic coupling. The results of these studies could be critical in the development of new treatments for osteoporosis, a common disorder affecting 54 million of the elderly in the US alone, as current treatments target either osteoclastic bone resorption or osteoblastic bone formation but none target the coupling process itself.

PI_NAMEs: ANDERSEN, THOMAS LEVIN GEISER;CHARLES, JULIA F (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;Age;Albers-Schonberg disease;Antibody Therapy;Automobile Driving;autosome;Back;Binding;Biomechanics;Biopsy Specimen;bone;Bone Diseases;Bone Formation Stimulation;bone fragility;bone loss;Bone Marrow Transplantation;bone mass;Bone remodeling;Bone Resorption;Bone structure;Caring;CD14 gene;Cell Nucleus;cell type;Cells;Cementation;Characteristics;Coculture Techniques;collagenase 3;Communication;Complement;Computer Assisted;cost;Coupling;Data;Development;Disease;Elderly;Endosteal Cell;Family;Future;Genes;Genetic Transcription;Goals;Heterozygote;Human;human model;Image;In Situ Hybridization;In Vitro;in vivo;Inherited;innovation;insight;Investigation;Knowledge;lens;Mature Bone;Mediating;Molecular;monocyte;mouse model;multimodality;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;overexpression;Pathologic;Patients;Peripheral;Phenotype;Physiological;Physiology;Process;progenitor;programs;Resources;Sampling;sex;single nucleus RNA-sequencing;skeletal;Skeletal bone;Testing;therapeutic target;TNFSF11 gene;tool;transcriptomics;translational impact;treatment strategy;Withdrawal;Work

PROJECT_TITLE: Mechanisms of bone fragility in Autosomal Dominant Osteopetrosis type II: from human to mouse and back

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The proposed studies will advance our understanding into the underlying biology linking dietary factors to healthspan. The data gleaned from these studies will help refine therapeutic or nutritional avenues to modulate lifespan and aging-related diseases resulting in a direct, positive impact on human health.

PI_NAMEs: MASHEK, DOUGLAS G (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acetylation;aging related;aging related disease;analog;Animals;Attention;Biogenesis;Biological;Biology;Caloric Restriction;Catabolism;Cell Nucleus;Cell Physiology;Charge;Clinical Trials;cofactor;Data;Deacetylation;deacylation;detection of nutrient;Development;Diet;dietary;Dietary Factors;Dietary Fats;Dietary Intervention;Dose;epidemiology study;extend lifespan;Fasting;FRAP1 gene;Glean;Health;Health Benefit;healthspan;healthy aging;Human;improved;innovation;interest;life span;Link;Lipids;Lipolysis;Literature;Machine Learning;Macronutrients Nutrition;Maps;Mediating;Mediterranean Diet;Metabolism;middle age;Mitochondria;model organism;Modeling;Monounsaturated Fatty Acids;Mus;mutant mouse model;novel;Nutrient;nutrient deprivation;Nutritional;Oils;old mice;Olive oil preparation;Olives - dietary;Outcome;Oxidation-Reduction;Pathway interactions;Peptides;Pharmacologic Substance;polyphenol;PPAR alpha;prevent;Proteins;Proteomics;Reaction;red wine;Research;response;Resveratrol;Role;Signal Transduction;Signaling Molecule;SIRT1 gene;Sirtuins;Source;Testing;Therapeutic;Time;Work

PROJECT_TITLE: MUFA-SIRT1 signaling as a central node regulating healthspan


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed prospective longitudinal study examines mutable psychological factors and social determinants of health factors that impact the development of daily living skills, and the downstream effect of daily living skills on quality-of-life for transition-age autistic youth. Autistic advocates have identified daily living skills—self-care, domestic, community skills—and quality-of-life as top research priorities, and we believe there are 3 major obstacles for autistic youth building the daily living skills and supports they need to become happy, productive adults: 1) current daily living skill interventions don’t work well and don’t generalize; 2) autistic people experience glaring inequities in access to care; and 3) daily living skills are not prioritized in treatment for all autistic adolescents but should be given their link with quality-of-life. The knowledge generated from this project will identify psychological factors that can be immediately integrated as targets into existing treatments and critical social determinants of health to target with policy—providing a foundational path toward improving promoting independence, happiness, and productivity for autistic adults.

PI_NAMEs: KENWORTHY, LAUREN ;YERYS, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: access disparities;Accounting;Address;Adolescence;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Advocate;Age;age group;autism spectrum disorder;autistic;Automobile Driving;Birth;caregiver education;Caregivers;Childhood;Cognitive;Communities;community living;Data;Development;Documentation;emerging adult;Employment;Employment Opportunities;Enrollment;Ensure;Environmental Risk Factor;Equity;Ethnic Origin;ethnoracial;evaporation;executive function;experience;Family;Gender;gender diverse;Happiness;Health education;Health Promotion;Health Services Accessibility;Healthcare;high school;Home;improved;Income;Independent Living;independent self care;indexing;Individual;individuals with autism spectrum disorder;Instruction;Insurance;Intervention;intervention delivery;Knowledge;Legal;Link;Longitudinal Studies;longitudinal, prospective study;Neighborhoods;non-verbal;Outcome;Participant;Play;Policies;prevent;Privatization;Productivity;psychologic;Psychological Factors;Public Health;Quality of life;Race;recruit;Research;Research Priority;Resources;Role;Sampling;Sampling Biases;Schools;Secondary Schools;Self Care;Self Determination;service delivery;service engagement;Service provision;Services;sex;sex assigned;Site;skills;social engagement;social health determinants;Social Justice;Societal Factors;Societies;System;Talents;targeted delivery;Teenagers;Testing;Time;transition to adulthood;Visit;Work;Youth

PROJECT_TITLE: A longitudinal study identifying psychological and service delivery targets to improve daily living skills and quality of life outcomes among transition-age autistic youth

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Tuberculosis is a global health threat. Mucosal-associated invariant T cells are promising innate-like sensors to induce protective immune responses. We will define the structures of Mycobacterium tuberculosis metabolites for stimulating MAIT cell responses to fight tuberculosis in humans.

PI_NAMEs: HUANG, SHOUXIONG  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Agonist;analog;Antibiotic Therapy;antigen binding;Antigen Presentation;Antigens;Antimycobacterial Agents;Bacterial Antigens;Bacterial Infections;Binding;Biological Assay;Biology;Blood;candidate identification;Cells;cellular targeting;Cessation of life;Chemical Structure;chemical synthesis;Chemicals;Chronic;Clonal Expansion;Complex;cytokine;Data;design;Dipeptidyl-Peptidase IV;Discrimination;Disease;Drug resistant Mycobacteria Tuberculosis;Elements;Escherichia coli;fighting;Future;global health;Growth;Health;High Pressure Liquid Chromatography;high risk;Hour;Human;human monoclonal antibodies;Immune response;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Introns;Ligands;Mass Spectrum Analysis;Measures;Mediastinal lymph node group;metabolomics;Modeling;Molecular;Molecular Target;Mucous Membrane;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nature;non-tuberculous mycobacterial infection;novel;Outcome;pathogen;Patients;Pattern;Peptides;Population;Predisposition;prevent;Primates;programs;Proteins;public health relevance;receptor;response;Risk;Role;sensor;side effect;Single Nucleotide Polymorphism;Structure;Structure of parenchyma of lung;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic Effect;Tissues;Toxic effect;transcriptomics;Tuberculosis

PROJECT_TITLE: M. tuberculosis metabolites to activate human mucosal-associated invariant T cells

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Infectious Diseases;Malaria;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed project is relevant to public health because evidence on the effectiveness, safety, acceptability, cost, and cost-effectiveness of focal mass drug administration (fMDA) for Plasmodium vivax transmission reduction has high potential to inform malaria policy and practice and help decrease the tremendous global burden of disease due to P. vivax. Thus, the project is relevant to NIAID’s mission to conduct applied research to understand, treat, and prevent infectious diseases.

PI_NAMEs: HSIANG, MICHELLE SANG (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acceleration;Address;Adherence;adverse event risk;Aftercare;Aminoquinolines;Anti-malarials;Applied Research;arm;asexual;Blood;burden of illness;Case Management;Chloroquine;Clinical;Communicable Diseases;Communities;comparative efficacy;comparison control;Consent;cost;cost effective;cost effectiveness;Cost Measures;cost-effectiveness ratio;Country;Data;density;Detection;Diagnostic;Dose;Drug resistance;Drug Targeting;Effectiveness;effectiveness evaluation;Eligibility Determination;Family;follow-up;Genetic Variation;Glucosephosphate Dehydrogenase;Glucosephosphate Dehydrogenase Deficiency;Half-Life;Health system;Hemolysis;high risk;Household;improved;Incidence;incremental cost-effectiveness;indexing;Individual;Infection;infection risk;Intervention;Life;Liver;Malaria;Mass Screening;Measures;member;meter;Microscopy;Mission;National Institute of Allergy and Infectious Disease;novel therapeutics;open label;Outcome;Peru;Pharmaceutical Preparations;pharmacovigilance;Plasmodium falciparum;Plasmodium vivax;point of care testing;Policies;Population;Prevalence;prevent;Primaquine;primary outcome;prophylactic;Public Health;public health relevance;Randomized;Randomized, Controlled Trials;rapid test;Recommendation;Relapse;risk minimization;Safety;Seasons;secondary endpoint;secondary outcome;Serious Adverse Event;Seroprevalences;standard of care;Testing;tool;transmission blocking;transmission process;treatment arm;treatment effect;urban area;vector control;Vivax Malaria

PROJECT_TITLE: Focal mass drug administration (fMDA) to reduce Plasmodium vivax transmission, a pragmatic cluster randomized controlled trial in Peru


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Macrophages are the first line of immune defense; upon recognizing immune threats they must initiate and coordinate pathogen-appropriate immune responses. Here, we will develop and apply new experimental and analytical workflows to measure the capacity of macrophages to generate stimulus-specific responses, and to use stimulus-response measurements to characterize functional cell states. This workflow is then applied to inflammatory and autoimmune disease mouse models to pioneer the quantitative assessment of Innate Immune Health.

PI_NAMEs: HOFFMANN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;aged;Autoimmune Diseases;Biological;Biosensor;cell behavior;Cells;Characteristics;Chromatin;Classification;Computer Analysis;Confusion;cytokine;Data;data integration;Data Set;Development;Disease;DNA;epigenomic profiling;epigenomics;experimental study;first responder;Future;Gene Expression;Gene Targeting;Genetic Markers;Health;Heterogeneity;Hyperactivity;Immune;immune health;Immune response;Immune Response Genes;In Vitro;Individual;individual response;Infection;Inflammatory;Injury;insight;Kinetics;Knowledge;Lead;Ligands;live cell microscopy;Machine Learning;machine learning classifier;Macrophage;Maps;mathematical model;Measurement;Measures;Mediating;Messenger RNA;Methods;Modeling;Molecular;Molecular Profiling;monocyte;mouse model;Mus;network models;Noise;novel;Obesity;pathogen;pathogen exposure;Pathologic;Pathology;Physiological;Population;Population Heterogeneity;predictive modeling;Reaction Time;receptor;reconstruction;Recording of previous events;Reporter;Research;response;Response to stimulus physiology;Sentinel;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Specificity;Stimulus;Testing;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;translational study

PROJECT_TITLE: Characterizing functional states of macrophages via their stimulus-responses

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Chronic Obstructive Pulmonary Disease;Cystic Fibrosis;Diabetes;Infectious Diseases;Lung;Rare Diseases

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Muco-obstructive airway diseases (MADs) are a major cause of morbidity and mortality worldwide and chronic Pseudomonas aeruginosa infection increases lung damage in individuals with MADs. Diabetes is a frequent comorbidity in MADs that potentiates P. aeruginosa virulence and antibiotic treatment failure. This proposal will examine the mechanisms driving worse outcomes in chronic diabetic lung infection with P. aeruginosa.

PI_NAMEs: THURLOW, LANCE R.;WOLFGANG, MATTHEW C (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Affect;Amino Acids;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Area;Automobile Driving;bacterial fitness;Bacterial Infections;bacterial metabolism;Behavior;Biological Models;Bronchiectasis;Carbon;Cause of Death;Cessation of life;Chemicals;Chronic;chronic infection;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Citric Acid Cycle;Clinical;comorbidity;Complex;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis related diabetes;Data;Dehydration;Detection;Diabetes Mellitus;diabetic;Disease;disease model;Environment;Failure;fitness;Fluorescence Microscopy;Genetic;Glucose;healthcare burden;Hyperglycemia;Immune response;Immunosuppression;In Vitro;in vivo;in vivo Model;Incidence;Individual;Infection;Inflammation;Life;Life Expectancy;Lung;Lung Diseases;Lung infections;lung injury;Measures;Metabolic;Metabolic Pathway;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;muco-obstructive airway diseases;Mucous body substance;Mus;mutant;novel;Nutritional;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Persons;Phenotype;Predisposition;Primary Ciliary Dyskinesias;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;pulmonary function;pulmonary function decline;Quality of life;Quantitative Reverse Transcriptase PCR;Recurrence;Research;Respiratory Failure;Respiratory Tract Infections;Role;Source;System;therapeutically effective;Treatment Failure;Virulence

PROJECT_TITLE: Impact of hyperglycemia on the pathogenesis of chronic bacterial lung infection

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]