NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE We propose to comprehensively explore the multi-level factors driving inappropriate thyroid ultrasound and identify candidate strategies for de-implementation using natural language processing, machine learning, mixed methods, Delphi process, and implementation mapping approach. 1

PI_NAMEs: BRITO CAMPANA, JUAN P (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: acceptability and feasibility;Age;Algorithms;Artificial Intelligence;Automobile Driving;Bankruptcy;Big Data;cancer care;cancer diagnosis;candidate identification;Caring;Characteristics;classification algorithm;Clinical;clinical center;clinical practice;Clinical Research;computable phenotypes;Computers;Continuity of Patient Care;cost;County;Data;Data Analyses;data modeling;Data Set;Databases;Deimplementation;Diagnosis;Disease;effectiveness testing;Endocrinology;Epidemiology;Ethnic Origin;Evaluation;experience;Financial Hardship;Guidelines;Health;health care delivery;Health system;Healthcare;Healthcare Systems;high risk;implementation intervention;implementation research;implementation strategy;improved;Incidence;Indolent;Intervention;Interview;Knowledge;Left;Lesion;Machine Learning;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Medical;Medical Record Linkage;medical specialties;Methods;Minnesota;Morbidity - disease rate;mortality;multidisciplinary;Natural Language Processing;Newly Diagnosed Disease;Output;overtreatment;Papillary thyroid carcinoma;Participant;Patient Care;patient oriented;Patient Selection;Patients;Personal Satisfaction;Persons;Phenotype;phenotyping algorithm;Population;practice factors;Prevalence;prevent;Probability;Procedures;Process;provider factors;psychosocial;Race;Radiology Specialty;Recommendation;Reproducibility;Research Methodology;rurality;Sampling;sex;Site;Structure;Surveys;System;Therapeutic;Thyroid Gland;ultrasound;United States;Validation;Wisconsin;Work

PROJECT_TITLE: De-implementation of inappropriate thyroid ultrasound

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE In biomedical and public health studies, careful planning is critical to ensure robust scientiﬁc results as well as efﬁ- cient use of resources. Part of that process involves estimating the sample size needed to obtain statistical results at the needed level of precision. This project develops new methods for estimation of sample size and statistical power in the widely-used “bread-and-butter” generalized linear models class of statistical analysis methods.

PI_NAMEs: RATHOUZ, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Age;analog;Applications Grants;Area;Attention;base;Chi-Square Distribution;Computer software;Data;Distal;Ensure;expectation;experience;Formulation;Foundations;Freedom;Future;Goals;in silico;indexing;interest;Investigation;Joints;Left;Linear Models;Logistic Regressions;Manuscripts;Mathematics;Measures;Mental Health;Methods;Modeling;Modernization;Nature;novel;novel strategies;Outcome;Paper;Population;Probability;Procedures;Process;Public Health;randomized, clinical trials;Research;Research Design;Research Personnel;Resources;response;Sample Size;sex;simulation;software development;Specific qualifier value;Statistical Data Interpretation;Testing;Time;usability;Work

PROJECT_TITLE: Power and sample size for generalized linear models

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Memphis

ORG_NAME: IMMUNO TECHNOLOGIES, INC.

ORG_STATE: TN

PHR: NARRATIVE We propose to develop intranasal, parainfluenza 5 (PIV5) viral-vector delivered vaccines against human Lyme disease for the US market. A recent new estimate of Lyme Disease by the CDC places the new number at 476,000 annual cases, up from 329,000 in 2015 which strongly suggests that the number of Americans affected by this vector-borne disease is increasing. A prime-boost vaccination with an intranasal vaccine is a scientific and technologic advance over the best vaccination protocols for Lyme Disease in development.

PI_NAMEs: GOMES-SOLECKI, MARIA  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Adult;Affect;aluminum sulfate;American;Animal Model;Antigens;Biological Assay;Borrelia burgdorferi;cell bank;Clinical Trials;commercialization;COVID-19;COVID-19 vaccine;Data;delivery vehicle;Development;Dose;Epitopes;Genetic;Human;Immune response;Immunity;Immunization;Immunization Schedule;Immunize;immunogenic;immunogenicity;Immunoglobulin G;Infection;Intranasal Administration;Investigational Drugs;Laboratories;Lead;Length;Longevity;Lyme Disease;Lyme Disease Vaccines;Marketing;Methods;Modeling;Monkeys;Mus;Needles;New Drug Approvals;nonhuman primate;novel;novel vaccines;old mice;OspA protein;OspA vaccine;Parainfluenza;Performance;Phase;Phase I Clinical Trials;pre-clinical assessment;preclinical study;prevent;Primates;Production;Qualifying;Research;response;Safety;Schedule;Self Administration;Small Business Innovation Research Grant;Specific qualifier value;subcutaneous;Technology;tick transmission;Ticks;timeline;Tissues;Trademark;Vaccination;vaccination protocol;vaccine access;vaccine candidate;vaccine delivery;vaccine efficacy;vaccine hesitancy;Vaccines;vector induced;Vector-transmitted infectious disease;Vero Cells;Viral Vector

PROJECT_TITLE: Intranasal Vaccine Against Lyme Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The gut microbiota plays a role in protecting humans from disease, digesting food, and shaping immune system function. This project will investigate bacterial mechanisms that control why microbial community composition differs from one individual to another. A deeper understanding of these genes and pathways will inform design of personalized probiotics to treat diseases where the gut microbiota is perturbed.

PI_NAMEs: WOLF, ASHLEY ROBIN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Actinobacteria class;Atherosclerosis;Bacteria;Biology;Carbon;Chronic;Communities;Complex;Computer Analysis;Consumption;Correlative Study;design;Diet;Disadvantaged;Disease;dysbiosis;Environment;Enzymes;Escherichia coli;Evolution;Food;Genes;Growth;gut bacteria;gut microbiome;gut microbiota;Heterogeneity;human disease;immune system function;Individual;Intestines;Knowledge;Laboratories;Link;Measures;Metabolic;Metabolic Pathway;microbial;microbial community;microbiota;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;Pathway interactions;Probiotics;Regulation;Regulatory Pathway;Repression;Research;Role;Shapes;single-cell RNA sequencing;Source;Therapeutic

PROJECT_TITLE: Regulation of carbon utilization in gut-resident bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Human Genome;Lung

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Public Health Relevance: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality, but we have not yet discovered treatments that significantly reverse the lung damage of COPD. In this study, we will continue a successful project that has already identified ACVR1B and TGFB2 as likely COPD-causing genes, and we will use new methods to directly observe alternative splicing in lung tissues and cell types in order to identify new COPD-causing genes and disease mechanisms. The genes and disease mechanisms identified by this project will advance efforts to identify new treatments for COPD that could improve the lives of millions of people affected by this disease worldwide.

PI_NAMEs: CASTALDI, PETER  (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: ACVR1B gene;Affect;airway epithelium;Alternative Splicing;Alveolar Cell;Apoptosis;Base Sequence;Bioinformatics;Biological Assay;Biology;Blood;Blood specimen;Cell Aging;cell bank;cell type;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoke;cohort;Data;differential expression;Disease;disorder risk;Drug Targeting;Elements;Epithelial Cells;FDA approved;Fibroblasts;Gene Expression;Genes;Genetic;Genetic Diseases;genetic variant;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;Hematological Disease;Human;Human Genetics;improved;Inflammation;Interdisciplinary Study;Leadership;Lung;lung injury;Maps;Measures;Methods;Minority;Molecular Biology;mortality;nanopore;novel;Persons;Phase;Phenotype;Play;programs;Protein Isoforms;public health relevance;Pulmonary Emphysema;Quantitative Trait Loci;Reporter;Research;Research Priority;Resources;RNA;RNA Splicing;Role;Sampling;Spliced Genes;Structure of parenchyma of lung;Technology;Testing;TGFB2 gene;Tissue Procurements;Tissues;Trans-Omics for Precision Medicine;transcriptome sequencing;Transforming Growth Factor Beta 2;Translational Research;Variant;Vascular Endothelial Cell

PROJECT_TITLE: Using Integrative Genomics To Identify and Characterize Emphysema-Associated eQTL

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: BIOLOGY

PHR: Project Narrative Mutation is the source of all evolutionary novelty and diversity shaping both the structure and sequence of genomes. The genomes of individual somatic cells also accumulate mutations throughout the lifetime of organisms impacting cellular functions and contributing to diseases. The goal of the proposed research is to understand at both the cellular and organismal level how cell-type, genotype, selective pressures, and evolutionary histories influence the structure and sequence of the genome.

PI_NAMEs: SUDMANT, PETER HESHEDAHL (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Architecture;base;cancer genome;Cell Physiology;cell type;Cells;Clonal Expansion;Complex;Computing Methodologies;Disease;Evolution;Genetic Variation;Genome;Genomic approach;Genomics;Genotype;Goals;Human;Individual;Inherited;interest;life history;life span;Malignant Neoplasms;Methods;Molecular;Mutation;Normal Cell;novel;Organism;Pan Genus;Pattern;Phenotype;Predisposition;pressure;Process;Radiation;Recording of previous events;Repetitive Sequence;Research;Shapes;Signal Transduction;Somatic Cell;Somatic Mutation;Source;Structure;Time;Variant;Vertebrates

PROJECT_TITLE: The evolution and diversity of mutation, molecular fidelity, and genome structure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Lung cancer is the second most common malignancy in the US with Human immunodeficiency virus (HIV)-infected individuals and AIDS patients at increased relative risk by 250% and younger diagnosis. HIV-infected cells secrete extracellular vesicles, such as exosomes, into the blood and other body fluids which we found to stimulate lung cancer growth in HIV-infected persons. This research will help us understand why and how HIV-associated exosomes promote cancer and find a new method to control lung cancer development and progression in the population of persons living with HIV.

PI_NAMEs: JIN, GE  (contact);WANG, BINGCHENG

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adjuvant;Age;Aging;Allografting;antiretroviral therapy;aptamer;Automobile Driving;Benign;Blood;Body Fluids;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;cancer specimen resource;cell motility;Cell Nucleus;Cell Proliferation;Cell secretion;Cells;Cessation of life;chemical carcinogen;Circulation;Data;Development;Diagnosis;Distant;Endocytic Vesicle;Endosomes;Engraftment;Epidermal Growth Factor Receptor;Epithelial Cells;exosome;extracellular vesicles;Foundations;FVB Mouse;General Population;Genetically Engineered Mouse;Growth;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV/AIDS;Human;Immune;Immunologics;In Vitro;in vivo;Individual;inhibitor;intercellular communication;KRASG12D;life span;Liposomes;Lung;lung allograft;lung cancer cell;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;MAPK3 gene;Maps;Mediating;MEKs;Membrane Proteins;Methods;migration;Mitogen-Activated Protein Kinases;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;patient derived xenograft model;Patients;Persons;Phosphorylation;Plasma;Population;Prevention;Production;Prognosis;Proteome;Proto-Oncogenes;Publishing;Ras/Raf;reconstitution;Relative Risks;Research;response;Response Elements;Risk;Risk Factors;RNA;Role;Signal Transduction;Site;Specimen;success;T-Lymphocyte;Testing;Therapeutic Intervention;TLR3 gene;Transactivation;Transgenic Mice;transplant model;trend;tumor;tumor progression;Tumor stage;Tumor Tissue;tumorigenesis;Urethane

PROJECT_TITLE: (PQ1) HIV-infected T-cell exosomes in lung cancer progression


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Most breast cancer exhibits an immunologically inactive tumor microenvironment, which is considered as a significant challenge for effective immunotherapies. Here, we will study how DDX3X controls the level of cellular double-stranded RNAs, and targeting DDX3X to restore tumor immunogenicity, and enhance antitumor activity in breast cancer.

PI_NAMEs: HAN, CECIL  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: anti-cancer;anti-PD1 antibodies;Antigen Presentation;aspartylglutamate;Biological;Biological Assay;Breast Cancer Cell;cancer cell;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;Cells;cellular targeting;Chronic;conditional knockout;CRISPR/Cas technology;crosslinking and immunoprecipitation sequencing;Cytoplasm;Detection;DNA Damage;DNA Methylation;Double-Stranded RNA;Elements;Epigenetic Process;Exhibits;experimental study;Family;Gene Deletion;Gene Expression;Genetically Engineered Mouse;Genomic Instability;glutamylalanine;helicase;Homeostasis;Human;human disease;Immune;immune activation;immune checkpoint blockade;Immune Evasion;Immune response;Immune signaling;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunologics;Immunomodulators;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammation;inhibitor;Innate Immune Response;innate immune sensing;Interferon Type I;Interferons;Invaded;knock-down;Link;Luciferases;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;Metastatic breast cancer;MHC Class I Genes;Mitochondria;Modification;Molecular;mouse model;Mus;new therapeutic target;Normal Cell;novel;overexpression;Oxidative Stress;pathogen;Pathway interactions;Production;promoter;Regulation;Reporting;response;RNA;RNA Editing;RNA Helicase;RNA Processing;Role;sensor;Signal Transduction;small molecule inhibitor;Somatic Cell;Source;STAT1 gene;System;Therapeutic;therapeutic target;Transcriptional Silencer Elements;transcriptomics;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Viral;Virus Diseases

PROJECT_TITLE: Targeting cellular double-stranded RNA homeostasis in breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Emory prepares physician scientists to tackle health promotion, disease treatment and the pursuit of research- intensive careers. We offer research training in the biomedical sciences, biomedical engineering (Emory/GA Tech joint program), public health and social sciences (such as anthropology and sociology) to diversify the physician scientist training force and enhance early appreciation of the power of multidisciplinary approaches. Clinical training across multiple sites that include Grady Memorial (level I trauma/safety net hospital), Emory University Hospital Midtown (urban community hospital), the Atlanta VA Medical Center (serving Veterans across northeast GA), Wesley Woods (geriatric hospital), and Children’s Healthcare of Atlanta cultivates appreciation for the specific needs of diverse patient populations.

PI_NAMEs: YUSTEIN, JASON  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The goal of this project is to develop new techniques and apply an innovative MR molecular imaging approach to monitor HP pyruvate metabolism in prostate cancer patients pre- and post-radiation therapy for the first time. While this study focuses on prostate cancer radiation therapy, these methods are designed to be applicable to other prostate cancer HP MRI studies and in general to other cancer investigations.

PI_NAMEs: BOK, ROBERT A;VIGNERON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: 3-Dimensional;Address;Biochemical;Bladder;Cancer Patient;cancer radiation therapy;Clinical;clinically significant;cohort;cost;Critiques;Data;design;Detection;detector;Development;disorder risk;early phase clinical trial;Excretory function;Exhibits;experience;Failure;fluorodeoxyglucose positron emission tomography;FOLH1 gene;Gland;Goals;Heterogeneity;high risk;Human;Image;Image Guided Biopsy;imaging approach;imaging biomarker;imaging scientist;improved;innovation;Institution;Interdisciplinary Study;Investigation;Isotopes;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurable Disease;Measures;Medical Imaging;men;Metabolic;metabolic abnormality assessment;Metastatic Prostate Cancer;Methods;Modeling;Molecular;molecular imaging;Monitor;Morbidity - disease rate;Neoplasm Metastasis;novel;Pathologic;Patients;Pelvis;Phase;Physicians;Positron-Emission Tomography;pre-clinical;Progressive Disease;Proliferating;Prostate;Prostate Cancer therapy;Pyruvate;Pyruvate Metabolism Pathway;Radiation Monitoring;Radiation Oncologist;radiation response;Radiation therapy;Reaction Time;Regimen;Research;Research Design;Research Project Grants;Residual Cancers;Residual state;Resolution;Roentgen Rays;Safety;Schedule;Scientist;Screening for Prostate Cancer;Signal Transduction;single photon emission computed tomography;Site;Stains;Techniques;Technology;temporal measurement;Testing;Time;Tracer;Translating;Translations;treatment response;tumor;uptake

PROJECT_TITLE: Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Two out of three people treated with select types of chemotherapy experience a side effect known as peripheral neuropathy that causes pain, discomfort and numbness in the extremities and contributes to poor quality of life. We do not know who is at greatest risk for this side effect or how patients and providers weigh the risks of neuropathy against the potentially life-saving benefits of cancer treatment. The proposed study will help identify patients at high risk for chemotherapy induced neuropathy and assess how patients and clinicians might use information about neuropathy risk to make better informed decisions about cancer care.

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact);CHUBAK, JESSICA ;NEUGEBAUER, ROMAIN

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adult;Affect;Age;analog;associated symptom;Awareness;Biometry;Breast;cancer care;cancer epidemiology;cancer invasiveness;cancer survivorship care;cancer therapy;cancer type;care systems;Caring;Characteristics;chemotherapy;chemotherapy induced neuropathy;Chemotherapy-induced peripheral neuropathy;Chronic;Clinical;Clinical Data;clinical decision-making;Clinical Trials;Colorectal Cancer;community based practice;Community Health;comorbidity;Complex;Computer software;Decision Making;Development;Diagnosis;disability;Disabling;Dose;Dose Limiting;Electronic Health Record;experience;experimental study;fall risk;follow-up;Goals;health care settings;Health Services Research;high risk;Impairment;improved;Individual;Interview;Journals;Life;Limb structure;Machine Learning;machine learning method;Malignant Neoplasms;mathematical ability;medication safety;Mental Depression;Methods;Modeling;Motor;Nature;Neuropathy;neurotoxicity;Newly Diagnosed;Numbness;Obesity;older patient;Oncology;Outcome;Pain;Patient Care;Patient Preferences;Patients;Peer Review;Peripheral Nervous System Diseases;Persons;Pharmacotherapy;Platinum;predictive modeling;Prevention;Provider;Publications;Quality of life;Race;Reporting;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;Sample Size;side effect;Statistical Models;survivorship;Symptoms;taxane;Testing;Thinking;Time;tool;Toxic effect;Translations;treatment choice;treatment duration;Treatment Protocols;Vinca Alkaloids

PROJECT_TITLE: Leveraging machine learning to improve risk prediction for chemotherapy inducedneuropathy

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Legionella pneumophila (Lp) is the agent of a severe form of pneumonia known as Legionnaires' disease and an intracellular parasite of amoebae when in its natural aquatic habitats and an intracellular parasite of macrophages and epithelia when it is introduced in the lungs. We have gained evidence that Lp expresses two functional forms of type IV pili (T4P), surface appendages that often mediate attachment to human cells and other important surfaces. T4P are part of a fuller understanding of pathogenesis and potential targets for disease diagnosis or prevention, and therefore, the proposed studies are aimed at determining how different forms of Lp T4P promote infection and in different ways.

PI_NAMEs: CIANCIOTTO, NICHOLAS P (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acanthameba infection;Acanthamoeba;Acanthamoeba castellanii;Adherence;Adhesions;aerosolized;Alveolar Macrophages;Amoeba genus;appendage;Area;Bacteria;base;Behavior;Cell Line;Cells;Clinical;Competence;contaminated water;Data;Development;Devices;Disease;disease diagnosis;disorder prevention;DNA;Electron Microscopy;Environment;Epithelial Cells;Epithelium;Filament;Fimbriae Proteins;Genes;Genetic;Genomics;Habitats;Human;Immunofluorescence Microscopy;Impairment;in vivo;Incidence;Infection;Inhalation;Knowledge;Legionella pneumophila;Legionnaires' Disease;Length;Link;Liquid substance;Lung;Macrophage;man;Mediating;Methods;Microbial Biofilms;Microscopic;Minor;Motility;Movement;mutant;Names;Organism;Parasites;pathogen;Pathogenesis;Pathway interactions;Pilum;Pneumonia;Prevention;programs;Protein Secretion;Proteins;Reporting;Research Project Grants;Risk;Role;Solid;Surface;System;Thinking;transcriptome sequencing;transmission process;United States National Institutes of Health;uptake;Variant;Virulence;virulence gene;Visualization;Work

PROJECT_TITLE: Rethinking Legionella pneumophila type IV pili and their roles in intracellular infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because we are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain’s response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve our understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders. Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but clinical outcome is suboptimal because we don’t understand how rTMS affects the brain and we do not have brain measurements that indicate when stimulation reaches the target location in the brain (target engagement) and when stimulation changes the target (plasticity). The goal of this proposal is to characterize the key signatures of the brain’s response to rTMS with high resolution using invasive brain recordings (Aim 1), investigate how these recordings relate to noninvasive brain measures (Aim 2), and study how noninvasive brain measures relate to clinical outcome after TMS treatment for depression. Linking noninvasive brain measures to both invasive measurements and clinical outcome can greatly improve our understanding of the brain mechanisms underlying TMS-induced clinical outcome and provide a path for optimizing TMS around these measures to improve clinical efficacy. Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal with up to half of patients not responding. A critical missing factor that may improve TMS treatment are markers that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key signatures of the brain’s response to TMS with high resolution using invasive brain recordings, and relate these measures to noninvasive recordings and clinical outcomes of TMS treatment for depression, which will provide a path for optimizing TMS around these measures to improve clinical efficacy. This research will help our understanding of how transcranial magnetic stimulation (TMS) affects the brain. We will develop new methods of measuring TMS-induced changes in brain activity with high spatial and temporal accuracy that is only possible with intracranial recording and relate them to noninvasive recording measures that are more commonly used and to treatment outcome in depressed patients receiving therapeutic TMS. The research will provide key markers of TMS stimulation that can be used to facilitate the development of better interventions and treatments for depression and potentially other psychiatric diseases. Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because we are missing brain markers that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain’s response to TMS with high resolution using invasive brain recordings, and relate these markers to noninvasive recordings and clinical outcomes of TMS treatment for depression. These brain markers can be used to optimize TMS around these measures to improve clinical efficacy for depression and potentially other psychiatric diseases. with up to half of patients not responding. A critical missing factor that may improve TMS treatment are markers that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key signatures of the brain’s response to TMS with high resolution using invasive brain recordings, and relate these measures to noninvasive recordings and clinical outcomes of TMS treatment for depression, which will provide a path for optimizing TMS around these measures to improve clinical efficacy.

PI_NAMEs: BOES, AARON D;KELLER, COREY J (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acceleration;Affect;Anterior;Auditory Perception;Back;Behavior;biomarker validation;Brain;Brain region;burden of illness;cingulate cortex;Clinical;clinical efficacy;clinical translation;comorbid depression;Computer Models;Cutaneous;Depressed mood;depressed patient;Development;disability;Dose;effective therapy;Electric Stimulation;Electrodes;Electrophysiology (science);encephalography;Enrollment;Epilepsy;Evoked Potentials;experience;Failure;Functional Magnetic Resonance Imaging;Goals;Human;Implant;improved;Individual;interest;Intervention;Intractable Epilepsy;Knowledge;Link;Location;Major Depressive Disorder;Measurement;Measures;Medical;Mental Depression;Mental disorders;Methodology;Methods;Modality;Morphologic artifacts;neural;neuromechanism;Neuronavigation;novel;novel strategies;Operative Surgical Procedures;Outcome;Participant;Patients;Pattern;Pharmaceutical Preparations;Phase;Physiologic pulse;Physiology;Population;Positioning Attribute;Prefrontal Cortex;Protocols documentation;Proxy;Psychiatry;Records;repetitive transcranial magnetic stimulation;Research;Resistance;Resolution;response;Rest;Scalp structure;Sensory;Signal Transduction;Source;spatiotemporal;Surface;Techniques;temporal measurement;Therapeutic;Time;tool;Transcranial magnetic stimulation;Translating;Treatment Efficacy;treatment optimization;Treatment outcome;Treatment Protocols;treatment-resistant depression;Work

PROJECT_TITLE: Investigating the neural mechanisms of repetitive brain stimulation with invasive and noninvasive electrophysiology in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Genetics;Kidney Disease;Lupus;Nanotechnology

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Narrative Systemic lupus erythematosus is a complex autoimmune disease that causes multiple organ damage linked to significant morbidity and mortality. The clinical heterogeneity of the disease is matched by a complex pathogenesis which involves many factors and mechanisms. The proposed studies will bring forward a new molecule (ADAM9) which contributes to the expression of the disease and may be targeted to treat the disease.

PI_NAMEs: TSOKOS, GEORGE C (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Abnormal Cell;Animals;Autoimmune Diseases;Autoimmunity;Beta Cell;Biochemical Process;Biological Markers;Blood Cells;Catalytic Domain;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Choristoma;clinical heterogeneity;Clinical Trials;Complex;conditional knockout;Cyclic AMP;Cyclic AMP Response Element;cytokine;Cytometry;Data;Development;Disease;disease heterogeneity;Disintegrins;Drug Delivery Systems;Engineering;Environmental Risk Factor;Epigenetic Process;Experimental Autoimmune Encephalomyelitis;experimental study;Funding;Gene Expression;Generations;Genetic;Genetic Transcription;Glutaminase;Growth Factor;Guide RNA;Histone Deacetylase;Hormonal;Human;Hypoxia;IL17 gene;Immune;Immune response;Immunologist;immunoregulation;In Vitro;Infiltration;Inflammation;insight;Interleukin-2;Kidney;Knockout Mice;Link;Lupus;lupus prone mice;lymph nodes;Lymphocyte;MADH2 gene;Metabolic Pathway;Metalloproteases;Molecular;Morbidity - disease rate;mortality;Mus;nanoparticle;nephrogenesis;new technology;novel;oligodendrocyte-myelin glycoprotein;Organ;organ growth;Pathogenesis;Pathogenicity;Pathology;Patients;Peptides;Peripheral;Peripheral Blood Lymphocyte;Persons;Pharmaceutical Preparations;Phosphorylation;preclinical study;Production;Progress Reports;Publishing;Pyruvate Dehydrogenase (Lipoamide)-Phosphatase;receptor;Research;response;Role;Series;Signal Pathway;Signal Transduction;Specimen;Spleen;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T cell infiltration;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Time;Tissues;transcription factor;Transforming Growth Factor beta;Transforming Growth Factors;translational scientist;Work

PROJECT_TITLE: Gene Transcription in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE Liver cancer affects Southeast Asian Americans disproportionately with higher death rates relative to other Asian Americans and relative to non-Asian Americans. This proposed research is one of the first comprehensive assessments of the social determinants of health of patients with this cancer with a special emphasis on understanding transportation/distance barriers as well as joblessness, trouble finding childcare, limited education, and other social determinants of health. These findings – in conjunction with an in depth career development plan for the principal investigator – will inform the testing of innovative and feasible solutions to eliminate these prevailing disparities.

PI_NAMEs: TRAN, NGUYEN H (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Affect;American;Anti-viral Therapy;Arizona;Asian Americans;cancer care;cancer health disparity;cancer therapy;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Child Care;Clinic;Communities;community based practice;Coupled;Data;Death Rate;Development Plans;Diagnosis;Disparity;disparity elimination;Early Diagnosis;Education;Equity;Ethnic Origin;experience;Florida;Future;General Population;Goals;Grant;Health;health disparity;Health Services Accessibility;Health system;Healthcare;improved;Incidence;Infrastructure;innovation;insight;interest;Intervention;Interview;Iowa;Knowledge;Learning;Malignant neoplasm of liver;Malignant Neoplasms;Manuscripts;Medical;Medical Oncologist;Mentors;Minnesota;mortality;multidisciplinary;novel;Outcome;Patients;Persons;Physicians;Play;Positioning Attribute;pragmatic intervention;Prevention;Primary carcinoma of the liver cells;Principal Investigator;Prospective cohort;Qualitative Methods;Qualitative Research;Race;Research;Research Personnel;Resources;Running;Rural;rurality;screening;Screening for Hepatocellular Cancer;Site;skills;social determinants;Social Distance;social health determinants;southeast Asian;statistics;Surveys;tertiary care;Testing;Therapeutic;Transportation;Travel;Unemployment;United States;Vietnamese;Viral hepatitis;Wisconsin;Work;Writing

PROJECT_TITLE: Working to Eliminate Care Disparities in Liver Cancer in Southeast Asian Americans: Transportation and Other Social Determinants of Health.


NIH_SPENDING_CATS: Neurosciences

PHR: PROJECT NARRATIVE For many ion channels activated by binding of multiple ligands at distinct domains, the sequence of binding events that drive gating of the central ion conducting pore are difficult to observe as they are obscured by averaging over asynchronous events in ensemble measures, challenge structural identification due to their transient nature, and often precede opening of the channel pore and thus do not elicit ionic currents. This project will employ an innovative combination of single-molecule and fluorescence imaging techniques that can resolve individual binding events and parse out the energy landscape governing the dynamic behavior and coordination of multiple binding sites for both agonists and drugs. The proposed work will fill a critical gap in our understanding of the sequence of energetic events during activation of cyclic nucleotide gated channels essential for visual and olfactory sensation, and resolve a long standing debate on the basis for drug modulation of GABAA receptors by benzodiazepines, one of the most widely prescribed class of psychotropic drugs today.

PI_NAMEs: GOLDSCHEN-OHM, MARCEL PAZ (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: addiction;Address;Affect;Agonist;analog;Anxiety;Behavior;Benchmarking;Benzodiazepine Receptor;Benzodiazepines;Binding;Binding Sites;Cells;Chemicals;Color blindness;Coupling;Cyclic GMP;cyclic-nucleotide gated ion channels;Cysteine;detection limit;Diameter;Disparate;Disulfides;DNA Sequence Alteration;Drug Modulation;Drug Targeting;Electrophysiology (science);Esthesia;Event;Fluorescence;fluorescence imaging;Foundations;Goals;Image;Imaging Techniques;Immobilization;Impairment;improved;Individual;innovation;Ion Channel;Ion Channel Gating;Ions;Kinetics;Knowledge;Label;Left;Ligand Binding;Ligands;Literature;Measures;Mediator;Membrane Proteins;Methods;Modeling;Molecular Conformation;molecular imaging;Muscle;nanophotonic;nanovesicle;Nature;Nervous System Disorder;novel therapeutics;Optics;Pain;Pathway interactions;Pharmaceutical Preparations;pharmacologic;predictive modeling;preference;Psychotropic Drugs;Quality of life;rational design;receptor;receptor binding;Reporting;Research;Role;Shapes;Signal Transduction;single molecule;Site;Stimulus;Synaptic Transmission;targeted treatment;Testing;therapeutic target;therapy development;three dimensional structure;Treatment outcome;Vesicle;Visual;waveguide;Work

PROJECT_TITLE: Mechanisms of stepwise activation and drug-modulation in ligand-gated ion channels.

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Normal cognitive function requires an adequate blood supply to support neuronal activity via neurovascular coupling, and recent evidence demonstrates that age-related cognitive decline is directly linked to reduced neuro- vascular coupling (NVC) responses. Based on the abundant literature in the field, our published preclinical results and preliminary data in humans, these series of studies are designed to assess a clinically relevant intervention to improve endothelial function and NVC responses in community dwelling older adults to prevent and, potentially to treat, age-related cognitive decline. We demonstrated that age-related decline in cellular nicotinamide adenine dinucleotide (NAD) levels is a critical mechanism that promotes impairment of cerebromicrovascular endothelial function and NVC responses, and we propose to target this mechanism via safe-to-use, as demonstrated in recent clinical trials, NAD supplement nicotinamide riboside in a double blinded, placebo controlled, parallel group study.

PI_NAMEs: THANOU, AIKATERINI ;YABLUCHANSKIY, ANDRIY  (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Address;Age;age related;age related decline;Age Years;Age-associated memory impairment;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;animal old age;Animals;arteriole;Attenuated;Blood Cells;Blood Vessels;Brain;brain endothelial cell;Brain region;cerebral microvasculature;Cerebrovascular Circulation;Circulation;Clinical;Clinical Research;Clinical Trials;clinically relevant;cognitive function;cognitive performance;Communities;Data;Dementia;design;Development;Double-Blind Method;effective therapy;endothelial dysfunction;Endothelium;Enzymes;Etiology;extracellular;Functional disorder;functional near infrared spectroscopy;hallmarks of aging;Human;Hyperemia;Impaired cognition;Impairment;improved;Individual;Intervention;juvenile animal;Laboratories;Laser Speckle Imaging;Link;Literature;Measures;Mediating;Metabolic;metabolomics;middle age;NADH;Neurocognitive;Neurons;neurovascular;neurovascular coupling;Nicotinamide adenine dinucleotide;nicotinamide riboside supplementation;nicotinamide-beta-riboside;normal aging;Nutrient;old mice;older adult;Older Population;Oral;Oxygen;Participant;Pathology;Pattern;Peripheral;Pharmacological Treatment;Placebo Control;Placebos;pre-clinical;preclinical study;preservation;prevent;Process;Production;Public Health;Publishing;Randomized;Reactive Oxygen Species;Reporting;Research;Research Design;response;restoration;Retina;retina blood vessel structure;Role;Sampling;Self Administration;Series;Serum;Supplementation;Testing;Time;tool;treatment effect;United States National Institutes of Health;Vascular blood supply;Vascular Cognitive Impairment;Vascular Diseases;Vascular Endothelium;Whole Blood;Withdrawal

PROJECT_TITLE: Effects of NAD restoration on neurovascular coupling in community dwelling older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Solving complex problems in human health and modern biology requires a diverse group of biomedical researchers who are trained in rigorous and transparent implementation and reporting of quantitative analysis of biological data. Accordingly, this program is designed to build and sustain an equitable and inclusive training environment in which a diverse group of PhD students will successfully gain quantitative, conceptual, technical, and professional skills that will allow them to conduct the rigorous and reproducible research to meet this challenge.

PI_NAMEs: JOHNSON, MARK AIKENS;LARSCHAN, ERICA NICOLE;MOWRY, KIMBERLY L. (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Interdisciplinary and Inclusive Predoctoral Training in Molecular, Cellular, and Biochemical Sciences


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Nutrition;Primary Health Care;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE This project will test the effect of a home delivered foods and kitchen skills (FoRKS) intervention among adult safety-net primary care patients who report food insecurity and have hypertension. Sixteen and 24-week blood pressure will be compared between participants randomized to FoRKS vs enhanced usual care. Additional outcomes include learning engagement, kitchen confidence and skills, and nutrition and food security.

PI_NAMEs: CLARK, DANIEL O (contact);HOLDEN, RICHARD J

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adult;aged;Anti-Hypertensive Agents;behavior change;Behavioral;Behavioral Mechanisms;Black race;Blood Pressure;Budgets;Carbohydrates;Chronic Disease;Communities;Consent;cooking;cost;cost effective;cost effectiveness;delivered meals;Dietitian;Disease Management;Drug Prescriptions;economic evaluation;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Engineering;Enrollment;experience;follow-up;Food;food insecurity;food resource;food security;Glycosylated hemoglobin A;Health;health disparity;Health system;Healthcare;Home;Hour;Household;Hypertension;improved;innovation;Intervention;intervention cost;Knowledge;Learning;learning engagement;Link;Maintenance;Medicaid;Medical;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;nutrition education;Nutritional;Outcome;pandemic disease;Participant;Persons;pilot test;post intervention;Preparation;Primary Care;primary care patient;Process;programs;Race;Randomized;Randomized, Controlled Trials;Recipe;Reporting;Resources;safety net;Sampling;satisfaction;screening;Self Efficacy;Self Management;sex;simulation;skills;social;social health determinants;Social support;Sodium;System;Testing;tool;Training;Transportation;treatment as usual;United Nations;United States National Institutes of Health;user centered design;videoconference

PROJECT_TITLE: Delivering Food Resources & Kitchen Skills (FoRKS) to Adults with Food Insecurity and Hypertension:  An RCT

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative The field of cancer metabolism has had significant clinical impact: imaging modalities, biomarkers, and new therapeutic targets have resulted from studying tumor metabolism in cell culture. However, many findings from cell culture studies have been difficult to replicate in vivo, suggesting additional factors that influence tumor metabolism. In this project I use clinically-matched, patient-derived xenografts to identify the factors that influence tumor metabolism in vivo.

PI_NAMEs: FAUBERT, BRANDON  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Affect;Aggressive behavior;Angiogenesis Inhibitors;Behavior;Biological Markers;Biology;Blood flow;Cancer Cell Growth;cancer imaging;Cell Communication;Cell Culture Techniques;Cell Line;Cells;Clinical;clinical imaging;Clinical Oncology;clinical translation;Consumption;Cultured Cells;Disease;Educational process of instructing;Experimental Models;FOXM1 gene;Functional disorder;Glucose;Grant;Heterogeneity;Histologic;Human;imaging agent;imaging modality;Immune;Immune Evasion;Immune response;Immune system;Immunocompetent;In Vitro;in vivo;Infiltration;Infusion procedures;insight;Intrinsic factor;Knowledge;Label;Lung;Lung Neoplasms;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mentors;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolic stress;Metabolism;Modeling;Molecular;mouse model;mRNA Expression;Mus;Mutation;new therapeutic target;novel;novel therapeutics;Nutrient;Outcome Measure;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Perfusion;pharmacologic;Phase;Phenotype;preference;Primary Neoplasm;protein expression;Reporting;Research;response;Role;Sampling;subcutaneous;Testing;Therapeutic;Tissues;Translating;tumor;tumor behavior;tumor metabolism;tumor progression;Tumor Tissue;uptake;Work;Xenograft procedure

PROJECT_TITLE: Identifying factors regulating cancer metabolism in vivo

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Cardiovascular diseases leading to heart failure, heart attack, and sudden death due to catastrophic arrhythmias (irregular heartbeat) remain the leading cause of death among American adults. The Training Program in Translational Cardiovascular Science fills a unique and critical gap by bringing together basic and clinical researchers and trainees with the goal of training versatile scientists who will be capable of thinking across disciplines and working from “molecule to bedside” to find new cures, treatments and fundamental advances in heart and vascular function.

PI_NAMEs: ECKHARDT, LEE LOCHBAUM;ROBERTSON, GAIL A (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Intestinal failure is a devastating disease with an incidence of 24.5 cases per 100,000 live births that if left untreated results in dehydration, malnutrition, and ultimately, death. As a pediatric surgeon, I often witness the significant loss of bowel resulting in intestinal failure, and the complications that arise from inadequate treatments such as parenteral nutrition, bowel lengthening procedures, teduglutide, or intestinal transplant. Tissue-engineered intestine is a potential therapeutic solution for these nutritionally crippled children; and understanding the developmental processes required to generate a fully functional intestine is relevant to the NIH's mission and a high priority to improve the lives of affected children.

PI_NAMEs: SPEER, ALLISON LEIGH (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Affect;Agonist;antagonist;Award;Calcium;career;career development;Caring;Cessation of life;Child;Childhood;Collaborations;Complex;Constipation;cost;Creativeness;Data;Dehydration;Development;Development Plans;Developmental Biology;Developmental Process;Disease;Ensure;Enteral;Enteric Nervous System;Environment;Epithelial Cells;Epithelium;experimental study;Failure;Funding;gain of function;gastrointestinal;gastrointestinal transplantation;Genetic;Goals;Human;human embryonic stem cell;Image;imaging modality;improved;In Vitro;in vivo;in vivo imaging;Incidence;innovation;Institution;intestinal barrier;intestinal epithelium;Intestines;Knock-out;Knockout Mice;Knowledge;Left;Live Birth;loss of function;Maintenance;Malnutrition;Measures;Medical center;Mentors;Mesenchyme;Mission;Modeling;Morbidity - disease rate;Morphology;mortality;Motility;multidisciplinary;Muscle;Near-infrared optical imaging;nervous system development;Nervous System Physiology;Neural Crest Cell;neurogenesis;Neuroglia;Neurons;novel;nutrient absorption;Nutritional;Operative Surgical Procedures;Organoids;Parenteral Nutrition;pathogen;Peristalsis;Permeability;pharmacologic;preservation;Principal Investigator;Procedures;Process;Production;programs;Publishing;receptor;Research;Research Design;Research Methodology;Research Personnel;Resistance;Role;Scientist;Serotonin;serotonin receptor;skills;Stains;success;Surgeon;Synapses;Syndrome;teduglutide;Testing;Texas;Therapeutic;Therapeutic Intervention;therapeutically effective;Tight Junctions;Time;Tissue Engineering;Training;Translational Research;Transmission Electron Microscopy;Transplantation;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Enteric Nervous System Development and Function in Human Intestinal Organoids

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Microbial Pathogenesis lies at the crossroads of Microbiology, Immunology, Infectious Diseases, and Host Defense. The Microbial Pathogenesis Training Program serves as a platform for the integrated training of predoctoral students and postdoctoral fellows by bringing together basic and clinical scientists for the exchange of ideas and the enhancement of research goals at the University of Utah.

PI_NAMEs: MULVEY, MATTHEW A (contact);PLANELLES, VICENTE

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Training Program in Microbial Pathogenesis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Lead Poisoning;Neurosciences;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Developmental lead exposure is still a significant public health problem resulting in long-term adverse cognitive and behavioral outcomes, yet the mechanisms through which lead causes these adverse outcomes are still not completely known. At the basic science level, understanding the molecular mechanisms that may be involved in the adverse effects of lead on the brain and behavior is important and will be addressed in proposed work by studying, for the first time, the effects of developmental lead exposure on a novel epitranscriptomic mechanism involving direct modification of RNA and its influence on gene expression levels and behavioral responses following developmental Pb exposure. The proposed studies will add a new dimension to the understanding of gene-environment interactions following developmental Pb exposure and set the stage for further studies that may ultimately impact treatment of Pb-induced cognitive/ behavioral dysfunction.

PI_NAMEs: SCHNEIDER, JAY S (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Adenosine;Adverse effects;adverse outcome;Affect;Animal Model;Animals;Antibodies;Auditory;Basic Science;Behavior;Behavioral;behavioral outcome;behavioral plasticity;behavioral response;Brain;Brain region;Chemical Dynamics;Child;Cognitive;Cognitive deficits;conditioned fear;crosslink;Cues;Data;design;Development;Dimensions;DNA;DNA Methylation;Environment;Environmental Exposure;Environmental Impact;epitranscriptome;epitranscriptomics;fat mass and obesity-associated protein;Female;Functional disorder;gene environment interaction;Gene Expression;Genes;Genetic Transcription;Hippocampus;histone modification;Immunoprecipitation;Impaired cognition;improved;knock-down;Lead;lead exposure;Learning;Life;Link;Literature;male;Medial;Mediating;Memory;memory consolidation;Memory impairment;memory process;memory recall;Messenger RNA;Methylation;Modification;Molecular;Mus;nervous system development;Neurodevelopmental Disorder;Neuronal Plasticity;neurotoxicity;Neurotoxins;novel;Outcome;Pathologic;Pathway interactions;Performance;Play;Post-Transcriptional Regulation;posttranscriptional;Predisposition;Prefrontal Cortex;Process;Promoter Regions;Public Health;Publishing;Rattus;Regulatory Pathway;remediation;Reporting;response;RNA;RNA methylation;Role;sex;stressor;Testing;Time;Training;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Translations;Untranslated RNA;Viral;virtual;Work

PROJECT_TITLE: The Role of m6A-RNA Methylation in Memory Formation and Recall and Its Modulation and Influence on Long-Term Outcomes as a Consequence of Early Life Lead Exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Prevention

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECR NARRITIVE Our project represents the first, large-scale, and most comprehensive effort to understand the gene-heavy metal interaction in human livers and its impact on nonalcoholic fatty liver disease (NAFLD). Our study has potential to identify high-risk metals and their key response genes, thus promoting the development of new strategies for NAFLD diagnosis, prevention, and treatment. Our study will also generate important data to be shared with the scientific community to advance research for NAFLD and other related diseases.

PI_NAMEs: CASSIDY-BUSHROW, ANDREA E;LIU, WANQING  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Adult;Affect;Age;aged;Alcohol consumption;Alleles;Area;ATAC-seq;Bioinformatics;Biopsy;Biopsy Specimen;cell type;Cells;Characteristics;Child;Chromatin;Chronic;chronic liver disease;Clinical;cohort;Collaborations;Collection;Communities;Complex;Data;Data Analyses;Deposition;Development;Diabetes Mellitus;Disease;disease diagnosis;disorder prevention;disorder risk;drug discovery;Environment;Environmental Exposure;Environmental Risk Factor;Exposure to;FDA approved;Fibrosis;Fostering;Freezing;Gene Expression;Genes;genetic makeup;Genetic Risk;genetic risk factor;genetic variant;Genome;genome wide association study;genome-wide;genome-wide analysis;Genotype;Goals;Health system;Heavy Metals;Hepatocyte;high risk;Histologic;Histology;Human;Immune;Individual;Industrialization;insight;Intervention;Knowledge;Liver;liver biopsy;Liver Cirrhosis;liver transplantation;Malignant neoplasm of liver;Maps;Mediating;Metabolic Diseases;Metabolism;Metal exposure;Metals;metropolitan;Michigan;Modeling;Molecular;Molecular Target;Multiomic Data;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel diagnostics;Obesity;Pathogenesis;Pathologic;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Pharmacotherapy;Population;Predisposition;Preparation;Prevention;Preventive;protective effect;Quantitative Trait Loci;Research;response;Risk;risk variant;Role;Severities;single-cell RNA sequencing;social;Statistical Models;stellate cell;Testing;Therapeutic;Time;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;Zinc

PROJECT_TITLE: Interaction between Genome and Heavy Metals in Nonalcoholic Fatty Liver Disease

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Abnormal mechanotransduction is the cause of several cardiovascular and brain disorders. Here, we aim to understand the process by which cells convert physical forces into chemical and electrical responses by studying mechanically activated Piezo1 channels that are involved in cardiovascular and blood diseases, amongst others.

PI_NAMEs: SYEDA, RUHMA  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Amino Acids;Anemia;Biochemical;Biological;Biological Assay;Biological Process;biophysical techniques;Biophysics;Brain Diseases;Brain Ischemia;Cardiovascular Diseases;Cardiovascular system;Cells;Chemicals;Complex;Coupled;Cryoelectron Microscopy;Data;Degenerative polyarthritis;Development;direct application;Disease;disease-causing mutation;Drug Design;Elements;Environment;Evolution;Exhibits;Exposure to;extracellular;Family;Functional disorder;Future;Glioma;Goals;Health;Hematological Disease;Homologous Gene;Human;Hypertension;insight;interest;Investigation;Ion Channel;Ions;Kinetics;Lateral;Link;Lipid Bilayers;Lipids;Liquid substance;Lymphatic Diseases;Malignant Neoplasms;mechanical properties;Mechanics;mechanotransduction;Medical;Membrane;membrane assembly;Membrane Proteins;Merkel Cells;Molecular;Molecular Biology;Molecular Machines;monomer;mutant;Neoplasm Metastasis;Nervous System Disorder;Neurons;Pain;painful neuropathy;patch clamp;Pathology;Physiological;Physiology;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Point Mutation;Population;pressure;Probability;Process;Property;Proprioception;protein purification;protein reconstitution;Protein Region;Proteins;Protocols documentation;Publishing;Pulse Pressure;reconstitution;Regulation;Reporting;Research Proposals;Resolution;Respiratory physiology;response;Role;sensor;Sensory;sensory system;Series;shear stress;single molecule;Somatosensory Disorders;Spinal Ganglia;Stimulus;Stress;Stretching;structural biology;Structure;System;Tertiary Protein Structure;Testing;therapeutic development;therapeutic target;therapeutically effective;Tissues;Touch sensation;Transmembrane Domain;tumorigenesis;United States;Vertebrates;voltage

PROJECT_TITLE: Permeation and Gating Mechanisms of Mechanosensitive PIEZO channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NORTHRIDGE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: PROJECT NARRATIVE This interdisciplinary research will provide a better understanding of the relationship between social determinants and biological mechanisms during the transitional period of late adolescence to young adulthood. Our findings could have strong implications for social justice measures as well as public health interventions to curb cardiometabolic disease. By studying interpersonal discrimination and the results of environmental racism as stressors, we begin to deconstruct the psychosocial and physical costs of allostatic load for Latinx youth so that future interventions will be approached not only from an individual, but also at a systemic level.

PI_NAMEs: TOLEDO-CORRAL, CLAUDIA MICHELE (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Advocate;Age;allostatic load;ambient air pollution;Area;Awareness;Behavior;Biological;biological adaptation to stress;Biological Markers;Brain;built environment;burden of illness;California;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;catalyst;Chronic;Chronic Disease;Clinical;Communities;Complex Mixtures;cost;Data;Data Collection;design;Development;diabetes risk;Diet;Discrimination;Disease;disorder risk;Environmental Exposure;Environmental Impact;environmental justice;Environmental Protection;Environmental Risk Factor;environmental stressor;Epidemiology;epidemiology study;ethnic difference;ethnic discrimination;ethnic disparity;Ethnic Origin;Evaluation;evidence base;Exhibits;Exposure to;Failure;Family;Family history of;follow-up;Functional disorder;Future;Genetic;Health;Health behavior;High Prevalence;high risk;high risk population;Homeostasis;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immune system;indexing;Individual;innovation;Interdisciplinary Study;Intervention;Knowledge;Latina;Latino;Latinx;Latinx population;lifetime risk;Link;Literature;Longitudinal cohort;Longitudinal Studies;Los Angeles;Measures;Mentors;Metabolic;Metabolic syndrome;microaggression;middle age;minority children;Nervous System Physiology;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;novel;Onset of illness;Pattern;perceived discrimination;Perception;Phenotype;Physical activity;Physiological;Physiology;Policies;Pollution;poor health outcome;Population;Predisposition;prevent;Preventive measure;Procedures;programs;psychosocial;Psychosocial Stress;psychosocial stressors;Puberty;public health intervention;Race;racial difference;racial discrimination;racial disparity;racism;Recording of previous events;Research;Risk;Role;Saliva;Schools;Serum;Sleep;Smoking;social;social culture;social determinants;Social Environment;social implication;Social Justice;Social Policies;sociodemographic factors;Stress;stressor;Students;suburb;System;Targeted Research;Testing;Time;tool;Training Programs;Universities;virtual;young adult;Youth

PROJECT_TITLE: Allostatic Load in Latino Youth (ALLY) study: The Role of Discrimination and Environmental Racism


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Abnormal vision during a childhood ‘critical period’ can cause amblyopia, also known as lazy eye, a disorder comprising several deficits in spatial vision including impaired binocular depth perception. The proposed research is relevant to public health because knowledge of the neuronal basis and developmental timeline of binocular depth perception will improve our understanding of targets for therapeutic intervention. The proposed research is relevant to the mission of the NEI/NIH to increase understanding of how the development of the visual system and visual experience results in binocular depth perception.

PI_NAMEs: MCGEE, AARON W (contact);SAMONDS, JASON M

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;Affect;Age;Amblyopia;area striata;Attenuated;Behavioral;Binocular Vision;Biological Assay;Blindness;Calcium;Cataract;Characteristics;Child;Childhood;Complex;critical developmental period;critical period;Data;deprivation;Depth Perception;designer receptors exclusively activated by designer drugs;Development;Dimensions;Discrimination;discrimination task;Disease;Disparity;excitatory neuron;experience;experimental study;extrastriate visual cortex;Eye;Felis catus;Foundations;Genetic;Image;Impairment;improved;in vivo calcium imaging;Knowledge;Lazy Eyes;Measures;Mission;monocular deprivation;Monocular Vision;mouse model;Mus;neural circuit;Neurons;Ocular Dominance;Perception;Performance;Population;postnatal;Primates;Property;Psychometrics;Public Health;Rattus;Refractive Errors;Research;response;Rodent;Role;spatial vision;stereoscopic;Surgical sutures;Symptoms;Systems Development;targeted treatment;Task Performances;Testing;Therapeutic;Therapeutic Intervention;timeline;tool;two photon microscopy;United States National Institutes of Health;Vision;vision development;Vision Disorders;Vision Disparity;Visual;Visual Acuity;Visual Cortex;Visual impairment;Visual System

PROJECT_TITLE: Cortical basis of binocular depth perception

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Shifts between pathological and healthy brain states are fundamental features of many psychiatric disorders. Here we propose to investigate a novel mechanism mediating the transitions between network and behavioral states, which may provide insight into the episodic nature of psychiatric illnesses. We hypothesize that stress disrupts network function and behavioral states by impairing local neurosteroid signaling in the BLA and that increasing the capacity for endogenous neurosteroidogenesis can restore healthy network and behavioral states.

PI_NAMEs: MAGUIRE, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TITLE: Stress-induced impairments in endogenous neurosteroid signaling in the BLA negatively impacts network and behavioral states

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE The proposed short-term training for veterinary students blends expertise and resources across Tufts Cummings School of Veterinary Medicine and the Division of Comparative Medicine at the Massachusetts Institute of Technology to provide a rich, vibrant environment for trainees to engage in a diverse array of activities that include laboratory-based research, animal models of disease and comparative/translational medicine among others. This new collaborative will leverage the diverse scientific landscape within Massachusetts and provide unique opportunities for students to experience research within the context of academic centers, industry/biotechnology entities and contract research organizations. Importantly, veterinary students will explore alternative career choices in the context of a structured, engaging and supportive program led by veterinary scientists committed to generating trainee enthusiasm and interest in future research pursuits.

PI_NAMEs: LONDON, CHERYL A (contact);PATE, KELLY ANN METCALF

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: biocontainment facility;Biomedical Research;Biotechnology;Canada;Cardiovascular Diseases;career;Clinical Sciences;Communicable Diseases;comparative;Data;Device or Instrument Development;drug development;Education;Ensure;Evaluation;experience;Exposure to;field trip;Goals;industry partner;Institution;Laboratories;London;Manuscripts;Massachusetts;Medicine;Mentors;microbiome;New England;Oncology;Preparation;process improvement;Productivity;programs;Questionnaires;Recording of previous events;recruit;Reporting;Reproducibility;Research;Research Contracts;Research Training;responsible research conduct;Review Literature;Science;Series;Structure;Students;summer research;symposium;Technology;Toxicology;Training;Translational Research;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Visit;Work;Writing

PROJECT_TITLE: Cross-Disciplinary Research Training for Veterinary Students


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cytoplasmic mislocalization of TDP-43, an essential protein with critical roles in RNA processing and stability, is seen in over 95% of amyotrophic lateral sclerosis (ALS) cases and up to half of frontotemporal dementia (FTD) cases, and widely implicated in the pathogenesis of neurodegeneration. Mechanistic understanding of the basis of TDP-43 mislocalization in disease, and therapeutic strategies to oppose TDP-43 nuclear clearance, are urgently needed. Here, we will define the mechanism and key regulatory features of TDP-43 nuclear export, which our preliminary studies show is both energy- and RNA-dependent, and investigate the ability of RNA-based TDP-43 nuclear retention to attenuate neurodegeneration in patient derived neurons and Drosophila models of TDP-43 proteinopathy.

PI_NAMEs: HAYES, LINDSEY RENAE (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affinity;Amyotrophic Lateral Sclerosis;analog;Attenuated;Autopsy;Auxins;Axotomy;Binding;Biological Assay;blood-brain barrier crossing;Cell Line;Cell Nucleus;Cells;Cellular Assay;Chemistry;Collaborations;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Custom;Cytoplasm;Data;Defect;Diffuse;Diffusion;Disease;DNA;Dominant-Negative Mutation;Dose;Drosophila genus;drug development;Energy consumption;Exclusion;exportin 1 protein;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;helicase;In Vitro;in vivo;Induced Neurons;Injections;knock-down;Label;Libraries;Link;Mass Spectrum Analysis;Mediating;Messenger RNA;Microscopy;Modeling;Molecular;Molecular Chaperones;mRNA Export;Mus;mutant;Mutation;Nerve Crush;Nerve Degeneration;Neurons;neuropathology;neuroprotection;novel strategies;Nuclear;Nuclear Export;Nuclear Pore;Nuclear Pore Complex;Nuclear RNA;nucleocytoplasmic transport;nucleoside analog;Oligonucleotides;Pathogenesis;Pathway interactions;Patients;Permeability;Photobleaching;Pilot Projects;Play;pre-clinical;Preclinical Testing;prevent;protein TDP-43;Proteins;receptor;Regulation;RNA;RNA Binding;RNA Processing;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;sciatic nerve;Small Interfering RNA;Spliceosomes;subcutaneous;Temperature;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutic target;Tissues;transcriptome sequencing;Treatment Efficacy;Uridine;Validation

PROJECT_TITLE: RNA-based regulation of TDP-43 nuclear export in ALS/FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Leukemia patients carrying the rearrangement of the NUP98 gene exhibit particularly poor clinical outcomes, demanding a better understanding of how such diseases develop. This project aims to investigate the previously less-studied oncogenic function mediated by the unstructured protein region harbored within the leukemia-associated onco-proteins, which contributes to aggressive tumor phenotypes. The outcomes of the project may help develop new therapeutic strategies in future; therefore, the proposed research is directly relevant to public health.

PI_NAMEs: PHANSTIEL, DOUGLAS H.;WANG, G GREG  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;acquired factor;Acute Myelocytic Leukemia;Automobile Driving;Behavior Control;Binding;Biological Models;cancer cell;Cells;Chimera organism;Chromatin;Chromatin Loop;Chromatin Structure Alteration;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Disease;Dissection;DNA Binding;DNA Binding Domain;Enhancers;Exhibits;Fingers;Fusion Oncogene Proteins;Future;Gene Expression;Gene Fusion;Genes;Genetic Transcription;Genome;Genomics;Glycine;Goals;Hematology;Hematopoietic Neoplasms;Hematopoietic stem cells;Histones;homeodomain;HOXA9 gene;Human;In Vitro;insight;leukemia;Leukemic Cell;leukemic transformation;leukemogenesis;Liquid substance;Maintenance;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;N-terminal;novel;novel therapeutic intervention;Nuclear Pore Complex Proteins;Oncogene Activation;Oncogenes;Oncogenic;Oncoproteins;Outcome;Patients;Phase;Phenotype;Phenylalanine;Physical condensation;Plants;Prognosis;programs;promoter;Protein Region;Proteins;Proto-Oncogenes;Public Health;Recurrence;Research;RNA-Binding Proteins;Role;transcription factor;Treatment Failure;tumor;tumorigenesis

PROJECT_TITLE: The role for phase separation in oncogenesis and aberrant chromatin looping formation

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: The proposed research is relevant to public health because it focuses on the rational development of a therapeutic strategy targeting clinically occult breast cancer cells that persist despite current treatments. Once such a strategy has been developed, there is the potential for significant improvement in anti- cancer therapy to prevent tumor recurrence and disease progression. Thus, the proposed research is relevant to the mission of NCI through the development of improved treatments that would decrease morbidity and mortality in patients with breast cancer.

PI_NAMEs: MILLER, TODD W. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: adjuvant endocrine therapy;anti-cancer treatment;Antineoplastic Agents;Aromatase Inhibitors;biological adaptation to stress;Blood;Bone Marrow;Breast Cancer Cell;Breast Cancer Patient;cancer cell;cancer recurrence;cancer therapy;cancer type;Catabolism;Cell Line;Cell Survival;Clinical;Clinical Trials;Data;Dependence;deprivation;Development;Disease;Disease Progression;drug development;Drug resistance;drug resistance development;Drug Tolerance;Endocrine;ERBB2 gene;ESR1 gene;Estrogens;Excision;Exhibits;experience;fatty acid metabolism;Fatty Acids;Future;Goals;hormone therapy;Human;improved;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;lipid metabolism;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Metabolic;Metabolism;Mission;Mitochondria;Morbidity - disease rate;mortality;Neoplasm Metastasis;Operative Surgical Procedures;Outcome;oxidation;Oxidative Phosphorylation;Oxidative Stress;patient derived xenograft model;Patients;pharmacologic;Pharmacotherapy;Phase;Pre-Clinical Model;preservation;prevent;Production;Prognosis;Public Health;Recurrence;Recurrent disease;Recurrent tumor;Research;Resistance;Respiration;Role;Signal Transduction;Testing;Therapeutic;therapeutic development;Therapeutically Targetable;therapy development;Time;Tissue Model;treatment strategy;tumor;Tumor Tissue;Woman

PROJECT_TITLE: Therapeutically leveraging metabolic vulnerabilities in breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD);Vector-Borne Diseases

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Chromosomal variation plays an important role in several biological processes and is associated with multiple traits, yet the forces driving and maintaining this variation are not fully understood. This proposal tackles challenges regarding the evolution of two major features of the genomic landscape: chromosome inversions and sex chromosomes. By developing computational tools necessary for genomic analysis and by testing core hypotheses of the evolution of large genomic features, this work will make important strides in our understanding of how and why the structure of the genome changes through evolutionary time.

PI_NAMEs: GUERRERO, RAFAEL F (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Agriculture;Anopheles gambiae;Biological Process;Biology;Chromosome inversion;Chromosomes;comparative;computer infrastructure;Computer software;computerized tools;Data;Disease;driving force;Evolution;Female;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Polymorphism;Genetic Recombination;Genome;genome analysis;genome resource;genome-wide;Genomic Segment;Genomics;genus Solanum;Individual;Learning;Link;malaria mosquito;male;Movement;Mutation;Nature;offspring;open source;Phenotype;Plants;Play;Population;Process;programs;Research;Role;Scientist;sex;Sex Bias;Sex Chromosomes;simulation;Structure;System;Testing;Theoretical model;Time;trait;Variant;Work

PROJECT_TITLE: Computational tools and quantitative analyses of genome structure evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: We propose to investigate novel mechanisms of action of the SIRT7 enzyme in regulating chromatin – the structure in which the human genome is packaged – and how these mechanisms are linked to mammalian aging and cancer biology. Defects in chromatin regulation can contribute to numerous aging-associated pathologies, including cancer, metabolic and neurodegenerative disease. This proposal will provide new insights into how chromatin mechanisms regulate important cellular functions, and has the potential to identify new targets for therapeutic intervention.

PI_NAMEs: CHUA, KATRIN F. (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Acetylation;age related;Aging;aging mechanism;aging related;Attenuated;Automobile Driving;Biochemical;Biology;Biology of Aging;Cancer Biology;cancer cell;Cancer cell line;Cancer Etiology;Cell Aging;Cell Physiology;cell type;Cells;Cessation of life;Chemicals;Chromatin;chromatin modification;chromatin remodeling;Chromatin Structure;Coupled;Coupling;Deacetylase;Deacetylation;Defect;Disease;DNA;DNA Damage;DNA Methylation;Enzymes;Epigenetic Process;epigenomics;Event;Family;Gene Activation;Generations;Genetic Models;Genetic Transcription;Genome;Genomic Instability;genomic locus;Genomics;Goals;Histone Acetylation;Histone Deacetylation;Histone H3;histone modification;Histones;human cancer mouse model;Human Genome;in vivo;insight;KRAS2 gene;life span;Link;Longevity;Lung Adenocarcinoma;Lung Carcinoma;Lysine;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Metabolic Diseases;Methylation;Modeling;Molecular;mouse model;Mus;Mutation;neoplastic;Nerve Degeneration;Neurodegenerative Disorders;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Nuclear;Oncogenic;Oncoproteins;overexpression;Pathology;Pathway interactions;Phenocopy;Phenotype;pre-clinical;Premature aging syndrome;prevent;Process;programs;protective effect;Proteins;Regulation;Research;Resistance;response;restoration;Role;Saccharomycetales;senescence;Signal Pathway;Signal Transduction;Study models;Survival Rate;System;Testing;Therapeutic Intervention;Transact;tumor;tumorigenesis;United States;Work;Yeasts

PROJECT_TITLE: Histone Deacetylation Signaling in Aging and Cancer Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(02)M]


PHR: PROJECT NARRATIVE The overall goal of the Medical Scientist (MD/PhD) Training Program (MSTP) at the University of Wisconsin- Madison (UW-Madison) is to train physician-scientists in the broad range of research areas critical to advancing frontiers of medical knowledge and therapeutics. Integrated MD/PhD programs, by immersing trainees in research during what are arguably their most impressionable and creative years, are a key component of our country’s portfolio to provide such training and dovetail into the combined missions of UW-Madison and its School of Medicine and Public Health (SMPH). UW-Madison consistently ranks as one of the top 20 research universities in the world and is especially well-known for graduate education and contributions to society. Research and education related to biomedicine are carried out in a large number of departments, centers, and programs inside and outside of the SMPH that are integrated, collaborative, and span the many disciplines that will improve the health of our nation and world.

PI_NAMEs: HUTTENLOCHER, ANNA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Physicians;Scientist;Training

PROJECT_TITLE: Integrated Training For Physician-Scientists

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: FULLERTON

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: PROJECT NARRATIVE Brain-related aging and health, including Alzheimer's disease and related dementia (ADRD) have a profound impact on individual physical and mental functioning, and also on families and society. Therefore, investigation of neurocognitive aging and ADRD is crucial to our society and the individuals within it; however, we have too few trained underrepresented scientists to address the challenges of neurocognitive aging and ADRD faced by our increasingly diverse aging population. Our project will develop an exhaustive research training experience in neurocognitive aging ranging from basic neurobiology of neurodegenerative conditions, modifiable risk factors and health disparities related to neurocognitive aging, which will subsequently establish a talented, committed, and sustained pipeline of underrepresented students reflective of community demographics, who have unique perspectives, capable of addressing critical neurocognitive aging challenges in our changing world.

PI_NAMEs: BRASKIE, MEREDITH NICOLE;MCELIGOT, ARCHANA J (contact);TOGA, ARTHUR W

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;African American population;age related;age-related disease;Aging;aging brain;aging population;aging related;Alaskan;Alzheimer's disease related dementia;American;Area;Basic Science;Biomedical Research;Brain;brain health;career;career preparation;Cell Physiology;Censuses;Clinical Research;Clinical Trials;cohort;Communities;comparative;Competence;Computer Analysis;curriculum development;Data;Data Science;Degenerative Disorder;demographics;disadvantaged student;Disparity;Economics;Education;education research;Educational Curriculum;Educational workshop;Effectiveness;Enrollment;Ensure;Environmental Risk Factor;epidemiology study;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Population;Evaluation;evidence base;experience;Face;Faculty;faculty mentor;Family;Female;Funding;Future;Generations;Genetic Processes;genetic risk factor;Goals;graduate school;graduate school preparation;GRE Preparation;hands on research;Health;health disparity;health equity;Health equity research;Health Professional;health training;human old age (65+);Impaired cognition;improved;Individual;innovation;insight;interest;Investigation;Knowledge;Latino Population;Letters;male;meetings;mental function;Mentors;Mentorship;Minority;minority undergraduate;modifiable risk;Molecular;Multimedia;Native Americans;Nerve Degeneration;Neurobiology;Neurocognitive;neuroimaging;Neurosciences;next generation;Oral;Participant;Physical Function;Population;Population Heterogeneity;Population Research;Process;programs;racial diversity;racial minority;Readiness;Research;Research Methodology;Research Personnel;Research Training;Risk Factors;role model;Science;Scientist;Site Visit;skills;Social Environment;Societies;Statistical Data Interpretation;Students;success;Talents;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States;Universities;Vulnerable Populations;Writing

PROJECT_TITLE: Neurocognitive Aging & Analytics Research Education (NAARE)


ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative: LRRK2 is a multi-enzyme and multidomain protein that is associated with several diseases, including Parkinson’s disease, inflammatory bowel disease, tuberculosis leprosy, and Alzheimer’s disease. This study addresses several issues of central importance to understanding the structure and activity of LRRK2 by using biophysical and biochemical methods, which will show a molecular understanding of LRRK2 and how it might cause the disease mentioned above.

PI_NAMEs: HOANG, QUYEN QUOC (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;American;Arginine;Automobile Driving;Back;Binding;Biochemical;Biology;Biomedical Engineering;Biophysics;Cell model;Chemicals;Cryoelectron Microscopy;Data;Disease;Disease Progression;disulfide bond;Drug Targeting;early phase clinical trial;Engineering;Enzyme Kinetics;Enzymes;Family;Fingers;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hydrogen Bonding;Hydrolysis;Impairment;Inflammatory Bowel Diseases;inhibitor;inorganic phosphate;insight;kinase inhibitor;Length;Leprosy;LRRK2 gene;Measures;Methods;Molecular;Molecular Conformation;Molecular Mechanisms of Action;Monitor;Mutation;Nervous System Disorder;Nucleotides;Parkinson Disease;particle;Pathogenicity;Phage Display;Phosphotransferases;Process;programs;Property;protective allele;reduce symptoms;Regulation;Reporting;Research;screening;side effect;Structure;System;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Intervention;Tuberculosis;X-Ray Crystallography

PROJECT_TITLE: Molecular Mechanism of the Parkinson's Disease-associated protein LRRK2

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Project Narrative TNF inhibitors (TNFi) are biological anti-inflammatory drugs that are used worldwide as first or second-line treatment for chronic autoimmune diseases. Paradoxically, however, 15-30% of patients treated with TNFi develop anti-nuclear antibodies within 6 months of starting treatment and 0.2-1% develop clinical lupus. This project will use both mouse models and a cohort of human patients starting on TNFi to determine the mechanism for the induction of autoimmunity in the setting of suppression of B lymphocyte responses. These studies should enhance our knowledge of regulation of immune responses and may help to improve selection of patients for safe use of TNFi treatment.

PI_NAMEs: QUACH, TAM D (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;Age;Agonist;Amyloid fibers;Anti-Inflammatory Agents;Antibodies;Antibody Formation;Antibody-Producing Cells;Antigen-Antibody Complex;Antigens;Antinuclear Antibodies;attenuation;Autoantibodies;Autoimmune;Autoimmunity;autoreactive B cell;autoreactivity;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological;Cardiolipins;career development;CD22 gene;Cells;Chromatin;chronic autoimmune disease;Clinical;Clinical Research;cohort;Computational Biology;Computer Models;cytokine;Data;Defect;Demyelinating Diseases;design;Development;Development Plans;Disease;drug development;Drug usage;Education;Educational workshop;effective therapy;effector T cell;Environment;Escherichia coli;experience;Faculty;Follicular Dendritic Cells;Foundations;Future;Generations;Germ Lines;Goals;Grant;Homeostasis;Human;IL17 gene;Immune response;Immune system;Immunologist;immunoregulation;improved;In Vitro;Individual;individual patient;inhibitor;insight;instructor;interleukin-21;Knowledge;Ligands;Lupus;Mediating;Medical Research;member;Mentors;Methodology;Modeling;mouse model;Mus;mutational status;next generation sequencing;novel;Opportunistic Infections;Pathogenicity;Pathway interactions;Patient Selection;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Postdoctoral Fellow;predictive modeling;Predisposition;prevent;Pristane;Process;Production;Psoriasis;Reagent;Receptors, Tumor Necrosis Factor, Type II;Regulation;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;restoration;Rheumatoid Arthritis;RNA;Role;safe patient;Sampling;Self Tolerance;side effect;Signal Transduction;skills;SLEB1 gene;Source;Stimulus;Structure;Structure of germinal center of lymph node;System;Systemic Lupus Erythematosus;T-Lymphocyte;Technology;Testing;TLR2 gene;TNF gene;TNFRSF1A gene;TNFRSF1B gene;Training;Training Activity;United States;Vasculitis;Work

PROJECT_TITLE: The Role of TNF in Breaking B Cell Tolerance

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: NARRATIVE Schizophrenia represents a major public-health problem worldwide. In this proposal, we aim to combine genetic, developmental, fMRI, neurocognitive, and self-report data across several large-scale datasets to provide an integrated framework for the convergent pathophysiological mechanisms linking the complex genotypes to neural and behavioral phenotypes associated with the illness. In doing so, we hope to contribute to the development of novel brain-based biomarkers for diagnosis and treatment selection, and to help reduce the harmful stigma associated with schizophrenia, which could have important public-health repercussions.

PI_NAMEs: HORGA, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;age related;age related changes;Anxiety Disorders;Architecture;Automobile Driving;behavioral phenotyping;biobank;Biological;Biological Markers;biophysical model;Biophysics;brain based;Brain region;candidate marker;cell cortex;cell type;Cells;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;comparison control;Complement;Complex;Computer Models;connectome;connectome data;course development;Data;Data Reporting;Data Set;Development;Developmental Process;Diagnosis;Disease;Disparate;Distal;early onset;Equilibrium;Etiology;Exhibits;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;General Population;Genetic;genetic risk factor;genetic variant;genome wide association study;Genotype;hippocampal pyramidal neuron;Human;human disease;Hybrids;Impairment;indexing;Individual;interest;Interneurons;large datasets;large scale data;life span;Link;Measures;Mediating;Mediator;Memory impairment;Mental disorders;Methods;Mood Disorders;multimodal data;neural;Neurocognitive;Neurocognitive Deficit;Neurons;novel;operation;Pathway interactions;Patient Self-Report;Patients;Perception;Performance;phenomenological models;Phenotype;Population;Process;Psychoses;psychotic symptoms;Public Health;Recurrence;Reporting;response;Rest;Risk;risk variant;Role;Schizophrenia;schizophrenia risk;secondary analysis;Selection for Treatments;Severities;Shapes;Short-Term Memory;social stigma;Specificity;Testing;theories;trait;Validation;Work

PROJECT_TITLE: An integrative computational interrogation of circuit dysfunction inschizophrenia via neural timescales

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_STATE: CA

PHR: PROJECT NARRATIVE Characterizing the molecular and evolutionary basis of host-pathogen interactions may improve our understanding of the dynamics of human infectious diseases, help identifying therapeutical targets, and inform public health policies to combat future epidemics. Using ancient DNA obtained from archeological specimens, we can directly assess the signature of these interactions in the past and identify pathogen and human genetic variation lost with time. This research proposal centers on developing new resources (datasets and methods) for characterizing host-pathogen interactions and pathogen-driven human evolution using time-series data based on ancient DNA.

PI_NAMEs: GUERRA AMORIM, CARLOS EDUARDO  (contact)

PROJECT_TERMS: Bubonic Plague;combat;Communicable Diseases;Data;Data Analyses;Data Set;Detection;Development;Disease Outbreaks;DNA;European;Event;Evolution;experience;fitness;future epidemic;Gene Frequency;Genetic;genetic signature;Genetic Variation;Genome;genomic data;Goals;Health Policy;host-pathogen coevolution;Human;Human Genetics;Human Genome;human pathogen;improved;Indigenous;Knowledge;Light;Methods;Modeling;Modernization;Molecular;Mutation;Native American population;Natural Selections;novel;pathogen;Persons;Plague;Population;Positioning Attribute;Process;Public Health;Recording of previous events;Research Proposals;Resources;response;Sample Size;Sampling;Series;Site;South America;Specimen;Statistical Methods;statistics;Technology;therapeutic target;Time;time use

PROJECT_TITLE: Characterizing Human-Pathogen Interactions and Natural Selection with Ancient DNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research

ORG_CITY: CHICAGO

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Psychosocial interventions for chronic musculoskeletal pain have proliferated and show efficacy when compared to largely inert control conditions, but the effects appear to be no more than modest. To increase the potency of these treatments, we must identify specific and shared mediators, as well as reveal factors that predict whether a given treatment is most effective for a certain person. We will address this issue by comparing the mechanisms of three leading interventions for chronic pain: Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, and Emotional Awareness and Expression Therapy.

PI_NAMEs: BURNS, JOHN W. (contact);LUMLEY, MARK A

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Adult;Advisory Committees;Alexithymias;Awareness;Back;Behavioral;Belief;Brain;Characteristics;Chronic;chronic musculoskeletal pain;chronic pain management;Clinical;Cognitive Therapy;comparative;comparative trial;coping;Emotional;Event;improved;improved outcome;innovation;Intervention;Mediating;Mediator;Meta-Analysis;Modeling;Neck;novel strategies;Outcome;Pain;pain catastrophizing;Pain management;Pathway interactions;patient subsets;Patients;Persons;precision medicine;Predictive Factor;primary outcome;Process;Proliferating;psychosocial;Public Health;Randomized;Recommendation;Recording of previous events;Reporting;Research;Scientist;self-compassion;Spinal;Spine pain;Testing;Theoretical model;theories;Therapeutic;therapy development;Trauma;treatment as usual;treatment effect;Treatment Efficacy;treatment optimization;treatment response;virtual;Work

PROJECT_TITLE: Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]