FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_NAME: FESARIUSTHERAPEUTICS, INC.

PHR: NARRATIVE When autologous tissue is not available or split thickness skin grafts alone are used, full thickness skin loss may not heal or will heal by contracture of the surrounding skin. Current treatment approaches including engineered off the shelf products have significant limitations, including slow, inconsistent, and inadequate tissue formation, hence impaired wound healing. The commercialization of DermiSphereTM is expected to improve clinical practice in surgical fields where full thickness skin loss is common including, but not limited to, trauma, burns, and post- oncologic reconstructive surgery, by significantly decreasing the time required to achieve a healed wound, as well as increasing the thickness of the regenerated dermis in a scenario of full thickness skin loss.

PI_NAMEs: SAPIR LEKHOVITSER, YULIA  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Address;Anatomy;angiogenesis;Animal Model;Animals;Autologous;Autologous Transplantation;biomaterial compatibility;Burn injury;Care given by nurses;Cells;Cellular Infiltration;Clinical;clinical practice;clinically relevant;commercialization;Complication;Contracts;Contracture;Cues;Cyclic GMP;Data;Dermal;Dermis;design;design verification;Engineering;Esthetics;Excision;Expenditure;first-in-human;flexibility;Formulation;Freezing;healing;Healthcare;Human;Hypertrophic Cicatrix;Immobilization;Impaired wound healing;improved;Incidence;Infection;infection risk;Infiltration;innovation;Intention;Interview;Invaded;Lateral;manufacturing organization;Marketing;Morbidity - disease rate;Natural regeneration;Operative Surgical Procedures;Outcome;Patients;Performance;Phase;porcine model;prevent;Procedures;Process;product development;Reconstructive Surgical Procedures;regenerative;resilience;Resources;revascularization;scaffold;Site;Skin;Skin graft;skin regeneration;Small Business Innovation Research Grant;standard care;Surgeon;Technology;Technology Transfer;Tendon structure;Testing;Therapeutic;Thick;Thinness;Time;Tissues;Trauma;Validation;validation studies;Vascularization;Work;wound;wound bed;wound healing

PROJECT_TITLE: An Advanced Dermal Regeneration Scaffold for Reconstructive Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) is a deadly blood cancer that occurs mostly in adults over 65 and is associated with the abnormal overproliferation of blood stem cells, a common age-related condition called 'clonal hematopoiesis' (CH). Although we know that aging and specific gene mutations in the blood stem cells contribute to the development of CH and its progression to AML, we do not understand how old age and CH interact to promote the evolution of AML. Here, we will elucidate how aging and CH influence the propensity of blood stem cells to adapt to altered environments (“evolvability”), which could not only forge a new paradigm for our understanding of leukemia onset but also provide candidate pathways for the development of preventative interventions.

PI_NAMEs: DEGREGORI, JAMES V;LI, SHENG  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult;Age;age related;aged;Aging;Bar Codes;bisulfite sequencing;Blood;bone aging;Bone Marrow;cancer initiation;Cell Aging;Cell Nucleus;Cells;Chromatin;Clonal Evolution;Clonal Expansion;Clone Cells;Development;DNA;Elderly;Enhancers;Environment;Epigenetic Process;epigenetic regulation;epigenomics;Evolution;Exhibits;fitness;FLT3 gene;forging;Foundations;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Genomics;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Heterogeneity;high risk;human old age (65+);Individual;Inflammation;insight;Joints;leukemia;leukemic transformation;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;methylome;Molecular Profiling;Mus;mutant;Mutation;novel therapeutic intervention;old mice;Pathway interactions;permissiveness;Phenotype;Population;Predisposition;prevent;preventive intervention;Process;Proliferating;promoter;resilience;response;Risk Factors;self-renewal;single cell ATAC-seq;single-cell RNA sequencing;Somatic Mutation;stem cell biology;stem cell expansion;stem cell function;stem cell proliferation;Stress;Supporting Cell;Therapeutic;Time;transcriptome;transcriptomics;Transplantation;tumor heterogeneity

PROJECT_TITLE: The impact of reduction of cellular senescence on age-related epigenetic heterogeneity


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products;Neurosciences;Opioids

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE By modulating the activity of ligand gated ion channels (LGICs) and G-protein coupled receptors (GPCRs), complex natural products have the potential to reveal critical insight into the function of these therapeutically important membrane receptors. This proposal investigates the synthesis and evaluation of two classes of natural products and their development into new chemical tools to investigate LGIC and GPCR pharmacology. By providing new directions to rationally design small molecules that engage their receptors targets, the results from this research will ultimately lead to safer, more effective medicines.

PI_NAMEs: RILEY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;Alkaloids;Area;Award;Biological Assay;Biological Process;Chemicals;Complex;Coupling;Development;drug discovery;Economics;Evaluation;Family;Future;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Health;Human;improved;Indole Alkaloids;inhibitor;insight;Ion Channel Gating;kappa opioid receptors;Laboratories;Libraries;Ligands;Medicine;member;Membrane;Methods;Monitor;Natural Products;Natural Source;Nicotinic Receptors;novel;Opioid;Pharmacology;Protocols documentation;rational design;receptor;Research;Route;scaffold;Signal Transduction;small molecule;Synthesis Chemistry;Techniques;Therapeutic;tool;Work

PROJECT_TITLE: Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NORFOLK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Public Health Relevance Statement This proposal incorporates innovative, multi-disciplinary approaches to investigate mechanisms governing the regulation of cardiac contraction in health and disease. The ultimate goal is to markedly advance fundamental knowledge of striated muscle regulation and inform the rational design of tailored therapeutic interventions that could potentially improve cardiac muscle function in diseased hearts. Therefore, this proposal has substantial health relevance and is directly in line with the mission of the National Institutes of Health.

PI_NAMEs: CHASE, P. BRYANT;GALKIN, VITOLD  (contact);PINTO, JOSE RENATO

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 3-Dimensional;Actins;Affect;Algorithms;Bepridil;Binding;Binding Sites;Cardiac;Cardiac Muscle Contraction;Cardiomyopathies;Cardiovascular Diseases;Communication;Complex;Computing Methodologies;Cryoelectron Microscopy;Data;Development;Dilated Cardiomyopathy;Disease;disease-causing mutation;Distal;Distant;Electron Microscopy;Equilibrium;Filament;Genetic;genetic regulatory protein;Goals;Health;Heart Diseases;Hypertrophic Cardiomyopathy;improved;Incubated;individualized medicine;inherited cardiomyopathy;innovation;interdisciplinary approach;Knowledge;Lobe;Mission;Modeling;Molecular;Molecular Conformation;multidisciplinary;Muscle function;muscle physiology;mutant;Mutation;Myocardium;Myosin ATPase;outcome prediction;Pathogenesis;Pathogenicity;Phenotype;Phosphorylation;Physiological;public health relevance;rational design;reconstruction;Regulation;Research;Side;Site;Striated Muscles;Structure;Surface;Tail;Testing;Therapeutic Intervention;Thick;Thin Filament;Thinness;Time;tool;Tropomyosin;Troponin;Troponin C;Troponin I;Troponin T;United States National Institutes of Health;Variant

PROJECT_TITLE: The mechanisms of cardiac thin filament regulation in health and disease.

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The atomic-level details of lipid/enzyme interactions and the determinants of their specificity remain poorly understood, despite their importance in biosynthesis and modification of cellular membranes, and in the assembly and use of lipid conjugates for essential cellular functions such as glycosylation. By applying a structural biology-based integrated approach to enzymes that are involved in assembly of the peptidoglycan layer and modification of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria, biosynthesis of the mycobacterial cell well and processes of protein glycosylation, we will gain testable hypotheses on the basic principles of substrate recognition, and on how membrane, membrane enzymes, and lipidic substrates interact to facilitate these reactions. These data should also provide pathways toward new classes of therapeutics targeting lipid/enzyme active sites.

PI_NAMEs: MANCIA, FILIPPO  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Active Sites;Anabolism;Antibiotics;aqueous;Attention;Biochemical;Biochemical Reaction;Biochemistry;Biological Process;Catalysis;Cell Physiology;Cells;Cellular Membrane;Charge;chemical property;chemical reaction;chemical synthesis;Computational Biology;crosslink;Cryoelectron Microscopy;Data;Diphosphates;Environment;Enzyme Interaction;Enzymes;experimental study;Generations;Genetic;glycosylation;glycosyltransferase;Gram-Negative Bacteria;hydrophilicity;Hydrophobicity;Individual;interest;Knowledge;Ligands;Lipids;lipophilicity;Lipopolysaccharides;macromolecular assembly;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Modification;Molecular;mycobacterial;particle;Pathway interactions;Peptidoglycan;Physiological;Play;Process;Production;protein function;Protein Glycosylation;Proteins;Proteomics;Reaction;reconstitution;response;Role;Signal Transduction;Specificity;structural biology;Structure;Substrate Interaction;Substrate Specificity;sugar;System;therapeutic target;Time;tool;Work

PROJECT_TITLE: Structural basis of integral membrane enzyme function


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: PROJECT NARRATIVE The overarching goals of this project are to develop a marmoset model system to represent the neurobiology of the human brain and to develop a novel pluripotent stem cell/male germline-mediated transgenesis approach to advance the utility of the marmoset model to benefit the brain health research community. This supplement will introduce a promising undergraduate student from an underrepresented groups and disadvantaged background to this cutting-edge research in marmosets using bioinformatics to stimulate her continued interest in pursuit of research careers and provide her with key skills to make her a competitive applicant for MD-PhD programs.

PI_NAMEs: HERMANN, BRIAN PETER (contact);HSIEH, JENNY ;MCCARREY, JOHN R;NAVARA, CHRISTOPHER

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;Alleles;Authorship;Award;Bioinformatics;bioinformatics pipeline;Biological Models;Biology;Brain;Brain Diseases;brain health;BRAIN initiative;brain research;Callithrix;Callithrix jacchus jacchus;career;Career Choice;career development;Cell Transplantation;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Communities;Complex;Data Set;Derivation procedure;design;Development;disadvantaged background;Disease;Doctor of Philosophy;Dryness;Event;experience;experimental study;Exposure to;Faculty;First Generation College Students;Fostering;Foundations;Funding Opportunities;Gene Transfer Techniques;Genes;Genetic;Genome;genome editing;Germ Cells;Germ Lines;Goals;Health;Hispanic;Hispanic-serving Institution;Human;in vivo;Individual;induced pluripotent stem cell;infancy;innovation;innovative neurotechnologies;Institution;interest;International;Knowledge;Laboratories;Learning;life span;male;Manuscripts;Mediating;meeting abstracts;meetings;member;Mentors;Modeling;Modification;Molecular Biology;neural;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuropsychiatric disorder;nonhuman primate;novel;novel strategies;offspring;Oral;Paper;parent grant;parent project;Parents;Pluripotent Stem Cells;Polishes;Positioning Attribute;Postdoctoral Fellow;posters;Primates;Production;programs;Reporting;Research;Research Personnel;Science;Scientist;skills;sperm cell;Spermatocytes;Spermatogenesis;Students;success;symposium;Testis;Texas;therapy design/development;tool;Training;Training Support;transcriptome;transcriptomics;Transgenes;Transgenic Organisms;Transplantation;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: Spatial analyses of marmoset germline development


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

PHR: Project Narrative: Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with altered epigenomics and associated with high mortality. This proposal will explore if blocking Brd4, an epigenetic regulator, will block the upregulation of profibrotic genes thus alter the cell phenotype. This study will evaluate the efficacy of using Brd4 inhibitor as a therapeutic method to improve the resolution of persistent lung fibrosis; the completion of this study will further our understanding of this deadly disease and uncover novel therapeutic molecular targets.

PI_NAMEs: SANDERS, YAN  (contact);THANNICKAL, VICTOR J.

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acetylation;Acetyltransferase;Actins;Adult;Affect;Apoptosis;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological Assay;Bromodomain;C57BL/6 Mouse;Cardiac;Cell Physiology;cell type;Cells;Cellular Stress;Chromatin;chromatin immunoprecipitation;chromatin modification;Collagen;CRISPR/Cas technology;Data;Disease;Down-Regulation;efficacy evaluation;Elements;Enhancers;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;Family;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic Transcription;genome-wide;Hematology;Histone Acetylation;histone acetyltransferase;histone modification;Histones;idiopathic pulmonary fibrosis;improved;in vivo;in vivo Model;inhibitor;Kidney;Knockout Mice;Liver Fibrosis;Lung;Lung Diseases;lung injury;lung repair;Lysine;Maps;Mediating;member;Methods;molecular targeted therapies;mortality;Myofibroblast;NADPH Oxidase;novel;novel therapeutics;old mice;Organ;Pancreas;Pathogenesis;pharmacologic;Phase I/II Clinical Trial;Phenotype;Play;Post-Translational Protein Processing;Pre-Clinical Model;Process;profibrotic cytokine;promoter;Promoter Regions;Proteins;Pulmonary Fibrosis;Reader;recruit;Regulatory Element;repaired;Reporting;Research;Resolution;response;Role;Small Interfering RNA;Smooth Muscle;Solid Neoplasm;Testing;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Transforming Growth Factors;Up-Regulation

PROJECT_TITLE: Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Brain-immune crosstalk in myocardial infarction Project Narrative Myocardial infarction (MI) remains a leading cause of death worldwide. MI healing and functional recovery are critically determined by the immune system. This project combines state-of-the-art tools of neuroscience, cardiology, and immunology to investigate how the brain orchestrates the immune response to an MI and evaluates an innovative approach to improve MI outcomes by stimulating and inhibiting specific brain centers.

PI_NAMEs: POLLER, WOLFRAM CHRISTIAN (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Acute;Acute myocardial infarction;acute stress;Affect;Atherosclerosis;Autonomic nervous system;Blood Platelets;Bone Marrow;Brain;Brain region;Brain Stem;Cardiac;cardiac device;Cardiology;Cause of Death;cell type;Cicatrix;Clinical;Compensation;Corticotropin-Releasing Hormone;Data;Deterioration;Event;Fiber;Fright;functional outcomes;Genetic;healing;Health Care Costs;Heart;Heart failure;heart function;hemodynamics;Histology;Hormone Receptor;hospitalization rates;Hypothalamic structure;Immune;Immune response;Immune system;Immunology;improved;Infarction;Inflammation;Inflammatory;innovation;insight;Interruption;Intervention;Ischemia;Knockout Mice;Leukocytes;Leukocytosis;Life Expectancy;loss of function;Maps;Modeling;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Nature;Neuroimmune;neuronal circuitry;Neurons;Neuropeptides;Neurosciences;Nociception;optogenetics;Outcome;Output;Pain;Pathogenesis;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Phase;Photometry;Play;Primary Prevention;Process;Prognosis;Publishing;Quality of life;Recovery of Function;Research;response;revascularization;Risk;Role;Schedule;sensor;sensory input;sensory system;Shapes;Signal Transduction;Stress;Survivors;Techniques;Therapeutic;Therapeutic Intervention;Time;tool;Transcranial magnetic stimulation;translational approach;Viral;Visceral

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Predicting and controlling polygenic health traits using probabilistic models and evolution-inspired gene editing PROJECT NARRATIVE: DNA is passed down with multiple errors per generation, some mutations being beneficial, but the majority being neutral or causing health disorders. We can now correct these with CRISPR/Cas9, but the models that predict the consequences of such gene interventions are still not robust. I will conduct large-scale experiments with the plant A. thaliana to investigate the predictability of fitness impacts of DNA errors in many environmental conditions, and safely trial new gene editing approaches to reduce the number of mutations arising per generation and shift their beneficial-to-deleterious ratio.

PI_NAMEs: EXPOSITO-ALONSO, MOISES  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Agreement;Alleles;antagonist;Arabidopsis;Atlases;Award;Awareness;base editing;Biological Models;Biology;Budgets;career;CCR5 gene;Cell Culture Techniques;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;collaborative environment;Collection;Communities;Complex;Core Facility;Country;Creativeness;CRISPR/Cas technology;Dangerousness;Data;Development;Disease;Disease susceptibility;disorder risk;DNA;DNA Modification Process;DNA Repair;Doctor of Philosophy;Ecology;Education;Engineering;Ensure;Environment;Eukaryota;European;Event;Evolution;experience;experimental study;Faculty;fitness;Foundations;fundamental research;Funding;Future;gene-editing approach;Generations;Genes;Genetic;Genetic Diseases;Genetic Engineering;genetic manipulation;Genome;genome editing;genome-wide;Genomics;Geographic Locations;Germany;Goals;graduate student;Hand;Health;Heart;HIV resistance;Human;Human Genetics;human genomics;improved;Induced Mutation;insight;Institution;International;Intervention;Investigation;Knock-out;Knowledge;Laboratories;Lead;Learning;Location;Logistics;loss of function;Malignant Neoplasms;Mammals;Measures;Mediating;member;Mentors;Modeling;Molecular Biology;Molecular Genetics;Mouse-ear Cress;multidisciplinary;Mutation;Nonprofit Organizations;personalized genomics;Philosophy;Plant Model;Plants;Positioning Attribute;Postdoctoral Fellow;predictive modeling;Predisposition;professor;programs;recruit;Research;Research Personnel;research vision;resilience;resistance mutation;Resources;risk prediction;Science;Source;Spain;Statistical Models;statistics;Students;System;Testing;tool;Training;trait;undergraduate student;United Kingdom;Universities;Work;Workload

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Optic neuropathies due to heritable diseases, glaucoma, trauma or inflammation are a major cause of blindness in humans, but no effective treatments exist for the vision impairment that occurs with them. The goal of this project is to advance the speed and efficiency of research to improve retinal ganglion cell function, the cells damaged with these diseases, by developing a new nonhuman primate model of autosomal dominant optic neuropathy. This new and better animal model will speed the development and testing of innovative therapies by our team and others that will reduce the morbidity caused by optic neuropathies in humans.

PI_NAMEs: THOMASY, SARA MICHELLE (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;achromatopsia;Affect;Age;Anatomy;Animal Model;Animals;Apoptosis;Autosomal Dominant Optic Atrophy;autosome;Axon;Behavioral;Blindness;Breeding;Cell Density;cell injury;Cell Nucleus;Cell Physiology;Cellular Structures;Characteristics;Clinical;cohort;Color Visions;Communities;Contralateral;Data;Dendrites;density;Development;differential expression;Disease;disease model;Disease Progression;Drug Kinetics;Dynamin;dyschromatopsia;effective therapy;Electroretinography;Euthanasia;Exhibits;Eye;Flavoproteins;Fluorescence;Functional disorder;Future;Gene Mutation;Genes;Genetic;Glaucoma;Goals;Heritability;Heterozygote;Histologic;Homozygote;Human;human tissue;Immunohistochemistry;improved;Individual;Inflammation;Inherited;Innovative Therapy;Macaca;Macaca mulatta;macula;Measures;Missense Mutation;Mitochondria;Modeling;Monitor;Morbidity - disease rate;Morphology;mouse model;mRNA Expression;Multimodal Imaging;multiple omics;Mutation;Nerve;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;new therapeutic target;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Optic atrophy 1;Optic Disk;Optic Nerve;optic nerve disorder;optical imaging;Oxidative Stress;Pallor;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Persons;Phenotype;Physiology;Production;programs;protein expression;Protein Isoforms;Proteins;Research;Resolution;Resources;Retina;Retinal Cone;Retinal Ganglion Cells;retinal imaging;retinal nerve fiber layer;Scotoma;sight restoration;Signal Transduction;Speed;Testing;therapeutic evaluation;therapy development;Thick;Thinness;Time;transcriptome;transcriptomics;Trauma;Vision;vision science;Visual;Visual Acuity;Visual impairment

PROJECT_TITLE: Advancing novel therapies for optic neuropathy with a nonhuman primate model


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Nanotechnology;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE After an initial infection with many pathogens, the immune system provides protection against re-infection with the same pathogen. However, infection of the human female reproductive tract with Chlamydia trachomatis provides limited protection against reinfection, and reoccurring infections can cause permanent damage and infertility. The goal of this proposal is to 1) determine why the cells of the immune system fail to provide protection against C. trachomatis, and 2) reprogram these faulty cells using new vaccine approaches to provide protection.

PI_NAMEs: STARNBACH, MICHAEL N (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Affect;Antigens;Artificial nanoparticles;Automobile Driving;Binding;Biological Response Modifiers;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Immunity;Cellular Immunology;Cellular Structures;Chlamydia;Chlamydia trachomatis;Chronic;Cytosol;Cytotoxic T-Lymphocytes;Development;Effectiveness;Encapsulated;Epithelial Cells;Failure;female reproductive tract;Formulation;Goals;Health Care Costs;Human;human female;Immune system;Immunity;Immunize;Impairment;Individual;Infection;Infertility;Mediating;Membrane;Memory;Methods;Molecular;Morbidity - disease rate;Mus;nanoparticle;novel vaccines;Organism;pathogen;Pathology;Persons;Phenotype;prevent;Primary Infection;programs;Proteins;Reagent;reproductive tract;response;Route;secondary infection;Secondary to;Sexually Transmitted Diseases;success;synergism;T cell response;T memory cell;T-Lymphocyte;Testing;Vaccine Design;vaccine development;vaccine formulation;vaccine strategy;Vaccines;Vaccinia virus;Work

PROJECT_TITLE: Cytotoxic T Cell Mediated Immunity to Chlamydia

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

PI_NAMEs: WILLIAMS, CARLA  (contact)

PROJECT_TERMS: Antimicrobial Resistance;Basic Science;Biological;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Communities;Contracts;Emerging Communicable Diseases;gram negative aerobic rods;Gram-Positive Bacteria;Microbiology;National Institute of Allergy and Infectious Disease;pathogen;preservation;priority pathogen;product development;Production;Reagent;repository;Research;research and development;Resources

PROJECT_TITLE: Microbiology and Infectious Diseases Biological Resource Repository (MID-BRR)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CALIFORNIA FAMILY HEALTH COUNCIL, INC.

PI_NAMEs: NELSON, ANITA  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - CFHC


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: WILMINGTON

ORG_NAME: CHARLES RIVER LABORATORIES INTNTL, INC.

PHR: This contract provides supports the activities of the Division of Translational Toxicology (DTT) hazard identification activities (i.e., evaluating the harmful effects of various chemicals or physical agents) targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents of public health concern.

PI_NAMEs: MORRISON, JAMES  (contact)

PROJECT_TERMS: Adverse effects;Apoptosis;Autopsy;Cell Proliferation;Cellular biology;Chemicals;Consult;Contracts;Data;Development;developmental toxicity;disorder prevention;DNA;DNA sequencing;Electron Microscopy;Ensure;Environmental Exposure;Evaluation;Exposure to;Genotype;Government;Hazard Identification;Histology;Immunohistochemistry;immunotoxicity;In Situ;In Situ Hybridization;Journals;Laboratories;Laboratory Animal Medicine;Malignant Neoplasms;Manuscripts;Molecular Biology;molecular pathology;Morphology;National Institute of Environmental Health Sciences;National Toxicology Program;Pathology;Peer Review;Preparation;Procedures;Process;Public Health;Publications;Reporting;reproductive toxicity;Research Design;Research Personnel;research study;RNA;Services;Slide;Specimen;Stains;Support Contracts;Techniques;Time;Tissues;Toxic effect;Toxicology;Training;working group

PROJECT_TITLE: PATHOLOGY PEER REVIEW AND PATHOLOGY SUPPORT FOR THE DNTP AND DIR AT NIEHS" CHARLES RIVER LABORATORIES (CRL)


NIH_SPENDING_CATS: Cancer

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MEAGHER, KEVIN  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;biobank;Biological Assay;Biological Specimen database;cancer initiation;Cancer Patient;Catalogs;Clinical;Clinical Data;Collection;Communities;Community Hospitals;Consent;Data;Dedications;Electronics;Elements;eligible participant;Enrollment;Ensure;Equipment and supply inventories;ethical, legal, and social implication;Goals;Informed Consent;Institution;Malignant Neoplasms;Medical;Molecular;National Cancer Institute;Participant;Pathology;patient engagement;Patients;Physicians;Policies;Population;programs;Provider;Qualifying;Quality Control;Recommendation;Research;Research Personnel;Resources;Scientist;Site;Source;Specimen;standard of care;System;tumor;user-friendly;web site;Work

PROJECT_TITLE: "CANCER MOONSHOT BIOBANK ONLINE CATALOG.


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: DELLA VALLE, MARK  (contact)

PROJECT_TERMS: base;Computer software;Contractor;Contracts;Data;Data Security;Data Storage and Retrieval;design;Development;Environment;Equipment;Evaluation;falls;Future;Government;Government regulations;Infrastructure;Investigation;Licensing;Life Cycle Stages;Maintenance;migration;National Institute of Environmental Health Sciences;new technology;operation;Process;social;Source;Support Contracts;System

PROJECT_TITLE: CONTRACTOR: SOCIAL & SCIENTIFIC SYSTEMS, INC. TASK ORDER: 75N96021F00005 - IT INFRASTRUCTURE MAINTENANCE BASE PERIOD: JUNE 30, 2021 - JUNE 29, 2022


PI_NAMEs: JACKSON, BRAXTON  (contact)

PROJECT_TERMS: Area;base;Budgets;computerized data processing;Contractor;Data;Data Analyses;Data Files;data management;Data Security;Data Set;data sharing;Data Storage and Retrieval;Development;doctoral student;Documentation;Epidemiology;Human Resources;Lead;meetings;Monitor;National Institute of Environmental Health Sciences;Outcome;Paper;Postdoctoral Fellow;pre-doctoral;Regulation;Reporting;Research Personnel;Scientific Inquiry;Site;social;Support Contracts;System;Work

PROJECT_TITLE: CONTRACTOR: SOCIAL & SCIENTIFIC SYSTEMS, INC. TASK ORDER: 75N96021F00004 - STATISTICAL PROGRAMMING AND ANALYSIS BASE PERIOD: JUNE 30, 2021 - JUNE 29


PROJECT_TERMS: Area;Budgets;computerized data processing;Contractor;Data;Data Analyses;Data Files;data management;Data Security;Data Set;data sharing;Data Storage and Retrieval;Development;doctoral student;Documentation;Epidemiology;Human Resources;Lead;meetings;Monitor;National Institute of Environmental Health Sciences;Outcome;Paper;Postdoctoral Fellow;pre-doctoral;Regulation;Reporting;Research Personnel;Scientific Inquiry;Site;Support Contracts;Work

PROJECT_TITLE: TO4R: STATISTICAL PROGRAMMING AND ANALYSIS


NIH_SPENDING_CATS: Clinical Research;Patient Safety

PI_NAMEs: BERRY, BREANA  (contact)

PROJECT_TERMS: Accreditation;Adverse event;Agreement;Area;Caring;chemotherapy;Clinic;Clinical;clinical care;clinical center;Clinical Research;Clinical Research Protocols;Clinical Skills;Clinical Trials;Communities;Contractor;Contracts;Country;Data;data management;Databases;Diagnosis;Documentation;Ensure;Evaluation;Event;experience;Failure;follow-up;Guidelines;Healthcare;Home;Home Care Services;Hospitalization;Hour;Human Resources;Human Subject Research;Informed Consent;Institution;Intervention;Investigation;Joint Commission on Accreditation of Healthcare Organizations;Knowledge;Legal;Location;Maryland;Measures;Medical;Medical center;member;Monitor;National Institute of Environmental Health Sciences;Nursing Research;Occupations;operation;Operative Surgical Procedures;Outpatients;Patient Care;Periodicals;Persons;Physicians' Offices;Policies;Positioning Attribute;Preventive therapy;Procedures;programs;Protocols documentation;Publishing;Qualifying;quality assurance;Regulation;Reporting;Research;research study;Research Support;Resources;Risk;Risk Reduction;Role;screening;Serious Adverse Event;Site;Social Security Number;Specimen;Support Contracts;Training;United States;United States National Institutes of Health

PROJECT_TITLE: TASK ORDER 8R - CLINICAL RESEARCH UNIT (CRU) - STAFFING SUPPORT


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Mental Health;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: This year's conference goals are fully aligned with the NIH/NIDCD objective to improve the diversity of the research workforce and the conference faculty and student scholar awardees represent a racially, and ethnically diverse group. We are encouraged that NIH/NIDCD provides these diversity supplements in recognition that achieving this goal has costs. We believe that the funds we have requested here will catalyze meaningful progress toward that end and provide an enriching experience for students who aim to include research as part of their career goals.

PI_NAMEs: MARTIN, NADINE  (contact);REILLY, JAMES JOSEPH

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adult;Advocate;Affect;Audiology;Basic Science;career;Caregivers;Caring;Child;Chronic;Clinical;clinical practice;Clinical Research;Cognitive;cognitive neuroscience;college;Communication;Communication impairment;Companions;cost;Development;Discipline;Disease;Education;Environment;ethnic diversity;Evidence based intervention;experience;Faculty Workshop;falls;Fostering;Foundations;Funding;Goals;hands on instruction;Hospitals;implementation process;implementation science;improved;Inpatients;interest;Laboratories;Language;Language Disorders;Linguistics;Lived experience;meetings;Modeling;Motivation;National Institute on Deafness and Other Communication Disorders;neural;Neuropsychology;Persons;Population;posters;Public Health;racial diversity;Rehabilitation Centers;Rehabilitation therapy;Research;Research Personnel;Role;Schools;Science;Scientist;Series;social;Speech;Speech-Language Pathology;Students;symposium;theories;Thinking;Translating;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: The Eleanor M. Saffran Conference on Cognitive Neuroscience of Rehabilitation of Communication Disorders


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

PROJECT_TITLE: NIAID Division of AIDS (DAIDS) Chemotherapeutic Agents Repository


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Agreement;Cameroon;Collaborations;Development;Diagnostic;diagnostic assay;DNA;HIV;HIV-1;National Institute of Allergy and Infectious Disease;Performance;Pharmaceutical Preparations;Plasma;repository;Research;Specimen;vaccine trial;Virus;Work

PROJECT_TITLE: Identification and Characterization of Highly Diverse HIV-1 Viruses for Reference Panel Development


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The Medical Science Training Program (MSTP) at the Medical College of Wisconsin (MCW) provides integrated basic science and medical training as the educational foundation for future academic physician scientists. The mission of MCW-MSTP is to prepare students for careers as physician-scientists, which allows students to conduct hypothesis-driven research and to practice evidence-based medicine as an MD-PhD. MCW-MSTP welcomes all applicants, including students of diversity, students with disabilities, and students from socio-economically disadvantaged backgrounds.

PI_NAMEs: BARBIERI, JOSEPH T;SALZMAN, NITA H (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The rapid advances in biomedical sciences in the past 30 years has resulted in a critical need for well-trained investigators who also have direct involvement with clinical medicine to translate new discoveries in biomedical sciences into workable clinical applications. Medical Scientist Training Programs, such as the one at UAB, that train the most outstanding individuals in both modern medicine and the special intellectual perspective and technical know-how of basic biomedical science is a key component for meeting this need.

PI_NAMEs: YACOUBIAN, TALENE ALENE (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PI_NAMEs: WHITE, JON  (contact)

PROJECT_TERMS: Chemistry;Chemoprevention;Chemopreventive Agent;Contractor;Development;Division of Cancer Prevention;Equipment;Government;Human Resources;Intervention;Logistics;Maintenance;Malignant Neoplasms;Medical;National Cancer Institute;Prevention;programs;Qualifying;Quality Control;repository;Services;Source;Testing;Work

PROJECT_TITLE: CENTRALIZED CHEMOPREVENTIVE AGENT REPOSITORY AND CHEMISTRY SUPPORT


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Aging;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: RESTON

ORG_NAME: CARAHSOFT TECHNOLOGY CORPORATION

PI_NAMEs: DRINKWINE, TERRY  (contact)

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Cognitive resilience to Alzheimer’s disease (AD) and brain aging is a phenomenon whereby an individual’s cognitive functioning is better than predicted based on chronological age, genetic risk, and/or advanced neuropathology. Understanding the protective factors that improve cognitive resilience requires comprehensive identification of the protein components of unique brain cell types – an analysis that cannot be performed longitudinally in human patients. In this project, we will combine human clinical and molecular data with proteomic data from neurons and immune cells from the hippocampus of mice that are resilient and susceptible to cognitive decline to identify novel proteins and complexes that could ultimately be therapeutically targeted to delay or prevent cognitive symptoms in AD patients.

PI_NAMEs: KACZOROWSKI, CATHERINE COOK (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Age;age difference;Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amino Acids;Amyloid;asymptomatic Alzheimer's disease;Attention;Autopsy;Behavior;behavioral phenotyping;brain cell;brain tissue;candidate identification;cell type;Cells;Chronology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cohort;Communities;Complex;Data;data integration;Data Set;Databases;Disease;Disease Progression;DNA;drug discovery;Electrophysiology (science);Environmental Risk Factor;Exhibits;familial Alzheimer disease;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Risk;Genetic Transcription;Genetic Variation;Genomics;Grant;Hand;high dimensionality;high risk;Hippocampus;Human;human data;Human Genetics;Human Genome;human model;human tissue;Immune;Impaired cognition;improved;Individual;Ion Channel;Knowledge;knowledge base;Knowledge Portal;Label;Late Onset Alzheimer Disease;Learning;Link;Mediating;Memory;Memory impairment;Meta-Analysis;Methods;Microglia;Molecular;Molecular Analysis;Molecular Target;mouse model;Mouse Strains;multidimensional data;Mus;Mutation;Neurobehavioral Manifestations;neuroinflammation;neuronal excitability;Neurons;neuropathology;novel;Pathology;Pathway interactions;Patients;Phenotype;Population;Predisposition;prevent;promote resilience;protective factors;Protein Biosynthesis;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;Research;resilience;resilience factor;resilience in aging;Resources;response;RNA;Sampling;segregation;Shiga-Like Toxin I;spatial memory;Synapses;synaptic function;Synaptic plasticity;System;tau Proteins;Technology;Testing;The Jackson Laboratory;therapeutic target;Time;Transcript;transcriptomics;Translating;usability;Variant;Work

PROJECT_TITLE: Cell Type-Specific Proteins that Promote Resilience to Cognitive Aging and Alzheimer's Disease


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Cancer cells differ in their mechanical properties depending on their metastatic potential when measured in vitro. Understanding the role that a cell’s mechanotype plays in vivo at each step of the metastatic cascade will be critical for developing new diagnostics and therapeutic targets for metastatic disease, the cause of a majority of cancer-related deaths. This proposal seeks to understand the heritability of cell stiffness and the advantage or disadvantage conferred by cell stiffness to metastasis through the combination of high-throughput microfluidic mechanical screening, in vivo mouse metastasis models, and multi-omic analyses.

PI_NAMEs: YOUNG, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 4T1;Abate;ATAC-seq;Atomic Force Microscopy;Autopsy;bioluminescence imaging;Biomechanics;biophysical properties;Blood;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Cancer Biology;cancer cell;Cancer Model;career;cell behavior;Cell Death Process;Cell division;Cell Line;Cell Separation;Cells;Cessation of life;Circulation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CXCR4 gene;Data;Development;Devices;differential expression;Disadvantaged;Disease;Dissection;Disseminated Malignant Neoplasm;Distant;driving force;Dyes;Endothelium;Engineering;Epigenetic Process;epigenome;experimental study;Extravasation;Fatty acid glycerol esters;Fellowship;Flow Cytometry;Genes;Genetic;Genotype;Germ Cells;Goals;Heritability;immune function;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo Model;Individual;inhibitor;interest;Knowledge;Label;Link;Location;Luciferases;Lung;Malignant Neoplasms;mammary;MCF7 cell;MDA MB 231;Measures;mechanical properties;Mechanics;Microfluidic Microchips;Microfluidics;Migration Assay;Modeling;Molecular;Monitor;mouse model;multiple omics;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel diagnostics;old mice;orthotopic breast cancer;Phenotype;Play;Population;Positioning Attribute;Primary Neoplasm;Process;promoter;Property;Proteins;Proteomics;Research;Research Personnel;Resort;RNA Interference;Role;screening;Site;skills;Sorting;subcutaneous;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Training;transcriptome;transcriptome sequencing;tumor;Work;wound healing

PROJECT_TITLE: Phenotypic sorting of cancer cells to study the role and control of cell stiffness in the in vivo metastatic cascade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE We propose a pilot project to assess whether antibody-drug conjugates, an emerging class of anti-cancer drugs, are a viable treatment option for patients with uterine serous carcinoma. Briefly, we will survey a series of uterine cancer tissues to determine whether they express proteins that are targeted by antibody-drug conjugates, and then investigate whether we can combine antibody-drug conjugates with other therapies to increase their efficacy, especially in patients who show or develop resistance. We anticipate that our studies will seed future clinical trials of new treatment options for patients with uterine cancer.

PI_NAMEs: BAST, ROBERT C;SOOD, ANIL K (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Antibody-drug conjugates;Antineoplastic Agents;Biological Assay;biomarker driven;Carcinoma;Clinical Trials;Data;Development;DNA damage checkpoint;efficacy testing;Endometrial Carcinoma;Environment;ERBB2 gene;ERBB3 gene;Female Genital Diseases;folate-binding protein;Frequencies;Future;Goals;In Vitro;in vivo;Incidence;inhibitor;interest;Laboratories;Modeling;Molecular;mortality;mutational status;nectin;Patients;Pattern;Phosphotransferases;Pilot Projects;Play;Proteins;Resistance development;response;Role;Series;Serous;Solid Neoplasm;Stress;Surveys;Testing;Therapeutic;Therapeutic Trials;Tissue Microarray;Tissues;Topoisomerase;TP53 gene;Trastuzumab;tumor;Uterine Cancer;Uterus;VTCN1 gene;Work

PROJECT_TITLE: Targeting uterine serous carcinoma with antibody-drug conjugates


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Please see the Overall Core for the project narrative encompassing all cores.

PI_NAMEs: WESSELLS, HUNTER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Accreditation;Adult;Area;Bioinformatics;Biomedical Engineering;Cancer Center;career;career development;Caring;Cell Aging;Childhood;Chronic;Clinical;clinical care;cohort;Communities;community building;comparative;Complex;Degree program;Development;Diagnosis;Disease;Doctor of Philosophy;doctoral student;Education;equity, diversity, and inclusion;Evaluation;Event;experience;Faculty;faculty mentor;Feedback;forging;Fostering;Funding;Future;gene therapy;Genetic;Goals;Growth;Health;Health Care Costs;Hematological Disease;Hematology;improved;Inflammation;Infrastructure;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Kidney;Lead;medical specialties;Mentors;Mentorship;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Research Service Awards;Nephrology;Non-Malignant;Operative Surgical Procedures;organ on a chip;Outcomes Research;Pediatric Hospitals;peer;person centered;Pharmacology;physical separation;Physicians;Play;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Training;Resources;Robotics;Role;Schools;Science;Scientist;skill acquisition;sound;Standardization;Structure;success;support network;Time;TNFSF15 gene;tool;Training;Training Programs;Translating;Universities;urologic;Urology;virtual platform;Washington

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: No PHR

PI_NAMEs: KLEYMAN, THOMAS R (contact)

PROJECT_TERMS: Advisory Committees;Benign;Biomedical Research;career;clinical investigation;Dedications;design;Doctor of Philosophy;doctoral student;experience;Faculty;Fostering;Funding;Health system;Hematology;Individual;Industry;Investigation;Journals;Kidney;lectures;Medicine;meetings;member;Monitor;Nephrology;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Program Development;programs;recruit;Research;Research Project Grants;Research Training;Scientific Inquiry;Structure;Supervision;Training;Training Programs;Training Support;Translational Research;Universities;Urology;Work

PROJECT_TITLE: PCT-KUH: Pittsburgh center for training in kidney, urology and hematology


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Dental, Oral, and Craniofacial Disease;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Oral health during pregnancy and postpartum has significant impact on a woman’s overall health, birth outcomes and their child’s oral health. This study will provide evidence on how the generosity of state Medicaid dental benefits during pregnancy and postpartum impacts access to routine and emergent dental care. Understanding the effects of dental benefits generosity and duration is critical to inform policy decision-making and implementation of recent expansions of Medicaid dental benefits for pregnant and postpartum women aimed to improve maternal health outcomes.

PI_NAMEs: SINGHAL, ASTHA  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Age;Anxiety;Attitude;Attitude to Health;Awareness;Behavior;beneficiary;bilingualism;Birth;Cardiovascular Diseases;care providers;Child;Cilia;Clinical;Complement;Continuity of Patient Care;Country;Coupled;Data;Decision Making;Dental;Dental Care;Dentists;design;Development;Disease;Education;effective intervention;Electronic Health Record;Eligibility Determination;Ensure;Ethnic Origin;experience;Face;Florida;Focus Groups;Future;Gestational Diabetes;Health;Health behavior;Health education;Health Insurance;Health Knowledge Attitudes Practice;Health Services;Health Status;Hispanic Populations;Hispanic Women;Home;Hospitals;improved;Infant;Infant Health;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;Language;Light;Linguistics;Link;Literature;Marital Status;Maternal Health;Medicaid;Medicaid eligibility;Medical;Mental Depression;novel;Oral health;Outcome;parent grant;parent project;Participant;Periodicity;Pilot Projects;Policies;Population;Population Heterogeneity;post pregnancy;postnatal period;postpartum care;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;Race;Reporting;Research;Research Project Grants;service utilization;sociocultural determinant;sociodemographics;Spanish;Spanish/English;Surveys;United States;Visit;Woman

PROJECT_TITLE: Research Supplement to Promote Diversity in Health-Related Research Parent Project: Effects of Pregnancy and Postpartum Medicaid Dental Benefit Generosity On Use Of Dental Services

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: RIFKIN, DENA EVETTE (contact)

PROJECT_TITLE: The Training Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research Training


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Skin Cancer

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PI_NAMEs: GUO, HONGYAN  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Adjuvant;cancer immunotherapy;cancer therapy;cell killing;Cell Nucleus;Cells;Clinical;Cytoplasm;Extracellular Space;Herpesvirus 1;HMGB Family Gene;Human;immune cell infiltrate;immune checkpoint blockade;immunogenic;immunogenicity;Immunology;Immunotherapy;improved;Inflammatory;Malignant Neoplasms;Melanoma;Melanoma Tumor;Metastatic Melanoma;mouse model;Mus;mutant;Mutate;neoplastic cell;next generation;novel strategies;Nuclear;Oncolytic;oncolytic herpes simplex virus;Pathologic Processes;RNA;T-Lymphocyte;Therapeutic;Time;Treatment outcome;tumor;tumor microenvironment;Viral Proteins;Virus;Work

PROJECT_TITLE: Oncolytic Herpes Simplex Virus (HSV)1 as adjuvants for melanoma


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Magnetic resonance imaging (MRI) has evolved into an indispensable tool in clinical medicine and biomedical research. Yet, due to its high cost to purchase, site, and maintain, access to MRI is limited to mainly well-funded medical centers or research institutions. This project will test a new silent MRI technology that simplifies the MRI system in terms of its hardware components, cost, size, weight, and infrastructure requirements. Future portable MRI scanners based on this technology have a chance of empowering communities in remote, resource-limited settings to address health inequities, build local capacity for better health, improve understanding of brain development and degeneration in diverse populations, and enable access to high quality clinical care worldwide.

PI_NAMEs: GARWOOD, MICHAEL  (contact);PARKINSON, BENJAMIN JOHN;TANNUS, ALBERTO

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Amplifiers;Biomedical Research;Brain;Brain imaging;Clinical;clinical care;clinical diagnosis;Clinical Medicine;community empowerment;Computer Simulation;Computer software;cost;Democracy;Deposition;design;Development;digital;experience;experimental study;Frequencies;Funding;Future;Grant;Head;Health;health inequalities;High temperature of physical object;Human;human imaging;Image;Imaging Device;imaging system;Imaging Techniques;Improve Access;improved;Infrastructure;innovation;Institution;Laboratories;Machine Learning;magnetic field;Magnetic Resonance Imaging;Maintenance;manufacture;Measurement;Medical center;Medical Research;Methods;Modality;MRI Scans;neuroimaging;new technology;Noise;novel;Patients;Persons;Physiologic pulse;Population;Population Heterogeneity;portability;radio frequency;reconstruction;Research;Resolution;Resource-limited setting;Shoulder;Signal Transduction;Site;success;System;Techniques;Technology;Testing;Time;tool;transmission process;two-dimensional;Variant;Weight;Work

PROJECT_TITLE: Breakthrough Technology to Expedite the Democratization of High Field MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PI_NAMEs: GREKA, ANNA  (contact)

PROJECT_TITLE: Training Core


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project aims to create viscoelastic dynamic double network (DDN) hydrogels to define the influence of matrix properties on the generation of pancreatic organoids from induced pluripotent stem cells (iPSC). The viscoelastic DDN hydrogels are integrated from two interpenetrating networks, one elastic and one viscoelastic. This will allow us to define the physicochemical parameters critical for pancreatic exocrine cell fate determination and will advance our knowledge in matrix-guided organoid differentiation.

PI_NAMEs: LIN, CHIEN-CHI  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Adhesives;Adopted;Affect;Basement membrane;Basic Science;Biochemical;biophysical properties;Cell Differentiation process;Cell Therapy;Cells;Chemicals;Chemistry;Complex;design;Development;Diels Alder reaction;differentiation protocol;disease model;drug testing;Duct (organ) structure;Ductal Epithelial Cell;Ectoderm;Elasticity;Electrons;Encapsulated;Endoderm;Engineering;Esters;Exhibits;Exocrine pancreas;Extracellular Matrix;functional group;Future;Gel;Gelatin;Generations;Germ Layers;Glycols;Goals;human induced pluripotent stem cells;Hydrogels;improved;In Situ;In Vitro;induced pluripotent stem cell;innovation;Integrin alpha5beta1;Integrins;islet stem cells;Knowledge;Ligands;mechanical properties;Mechanics;Mediating;Mesoderm;Modeling;novel;Organogenesis;Organoids;Pancreas;Pancreatic Diseases;Pancreatic duct;patient derived induced pluripotent stem cells;Peptides;Pilot Projects;Polymers;Property;Proteins;Reaction;Regenerative Medicine;Relaxation;Role;Source;Specific qualifier value;stem cell biology;stem cell differentiation;stem cell fate;stem cell niche;stem cell organoids;stem cells;Stress;success;Surface;Technology;Testing;therapeutic evaluation;tissue regeneration;Tissues;Transcription Coactivator;translational applications;Trees;two-dimensional;viscoelasticity;Work

PROJECT_TITLE: Dynamic Double Network Hydrogel for Generating Pancreatic Organoids from InducedPluripotent Stem Cells

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE To sustain the considerable investments by the US government and in-country partners and ensure the well- being of older people living with HIV, the next phase of the HIV response must also focus on aging-related quality of life for the 25 million people living with HIV in sub-Saharan Africa. The current project directly addresses this goal by 1) determining the epidemiology, phenotypes and pathophysiology of cognitive impairment among older people with HIV in Uganda, 2) measuring the impact of cognitive impairment on the economic and psychosocial well-being of their households, and 3) identifying contextually-relevant risk factors for cognitive impairment. In doing so, this project will respond to numerous gaps in our understanding of cognitive impairment in Uganda and lay the groundwork for interventions to improve the health and quality of life for older people with HIV in the region.

PI_NAMEs: SIEDNER, MARK J (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;African;Age;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-42;antiretroviral therapy;Attention;Biological Markers;Blood Vessels;Brain imaging;brain magnetic resonance imaging;care giving burden;Caregivers;Characteristics;Classification;Clinical;clinical diagnosis;clinical phenotype;Cognition;Cognitive;cognitive function;cognitive neuroscience;cohort;Cohort Studies;Complex;Consensus;Country;Data;Dementia;Diagnosis;Diagnostic;Disease;disease phenotype;economic impact;economic outcome;Economics;Elements;Employment;Ensure;Epidemiology;Etiology;Evaluation;experience;Functional disorder;Funding;Genetic Variation;Glial Fibrillary Acidic Protein;Goals;Government;Health;health determinants;high dimensionality;High Prevalence;HIV;HIV Seronegativity;Household;human old age (65+);Image;Imaging Techniques;Impaired cognition;improved;Income;Individual;Inflammation;Intervention;Investments;Life Expectancy;Light;Loneliness;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measures;member;Mental Health;mild cognitive impairment;Modeling;multidisciplinary;neurofilament;neuroimaging;neuroinflammation;Neuronal Injury;Neuropsychological Tests;Neuropsychology;novel;older adult;Older Population;Opportunistic Infections;Participant;Pathway interactions;Personal Satisfaction;Persons;Phase;Phenotype;phenotypic data;Plasma;Population;population based;Population Heterogeneity;Prevalence;prevent;programs;prospective;psychosocial;psychosocial outcome;psychosocial wellbeing;Public Health;public health priorities;Quality of life;Research;research clinical testing;Research Personnel;Research Priority;Resources;response;Risk;Risk Factors;Sampling;Scientist;screening;sex;social;social engagement;social health determinants;social stigma;Societal Factors;sociodemographics;Specialist;Surveys;symposium;tau Proteins;Techniques;Testing;Training;Uganda;Vascular Diseases;White Matter Hyperintensity

PROJECT_TITLE: Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in Uganda

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Although HIV infection rates have seen reductions with advances in healthcare and therapy, the number of people living with HIV continues to increase. In order to protect the larger populace against HIV infections, a safe and effective vaccine is in urgent demand. The goal of this project is to develop functional nanomaterials capable of effectively delivering mRNAs encoding HIV immunogens as a vaccine candidate.

PI_NAMEs: DONG, YIZHOU  (contact);IRVINE, DARRELL J

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;adaptive immunity;Adjuvant;Affect;Agonist;Animal Model;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B-Lymphocytes;Biological Assay;Biological Response Modifiers;CD8-Positive T-Lymphocytes;Cell model;Cells;Cellular Immunity;Charge;Chemicals;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Country;COVID-19 vaccine;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;emerging pathogen;Engineering;env Gene Products;Epidemic;Epitopes;Europe;Exhibits;experience;Formulation;Future;gag Gene Products;Gene Expression;glycosylation;Goals;health goals;Healthcare;healthcare burden;high volume manufacturing;HIV;HIV Antigens;HIV Infections;HIV vaccine;Human;Humoral Immunities;Immune;Immune response;immunogenicity;in vivo;infection rate;Knowledge;Lead;lipid nanoparticle;Macaca;Mannose Binding Lectin;Mediating;Messenger RNA;Modeling;Moderna COVID-19 vaccine;mouse model;mRNA delivery;Mus;nanomaterials;nanoparticle;Nanotechnology;neutralizing antibody;nonhuman primate;Organ;particle;Pathway interactions;Pattern;Persons;Pfizer-BioNTech COVID-19 vaccine;Polymerase;Population;Post-Translational Protein Processing;pre-clinical;preclinical study;Process;Production;Property;Proteins;Public Health;Recombinants;Regimen;Reporting;Research Personnel;Resistance;RNA;RNA vaccination;RNA vaccine;Safety;side effect;SIV;South Africa;Stimulator of Interferon Genes;Structural Protein;Surface;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;technology platform;Thailand;TLR7 gene;Toll-like receptors;Transcript;Translations;Untranslated Regions;Vaccinated;Vaccination;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine discovery;vaccine platform;Vaccines;Viral;Viral Antigens;Virus Diseases

PROJECT_TITLE: Integration of adjuvant derived nanoparticles and engineered mRNA for HIV vaccine discovery

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Data Science;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

PHR: PROJECT NARRATIVE HIV/AIDS is a leading cause of morbidity and mortality among children and adolescents, and robust estimates of the HIV burden among these age groups are needed to inform intervention priorities and monitor progress toward global targets. The goal of this study is to address limitations of existing methods by triangulating empirical data sources to produce more accurate and comprehensive estimates of pediatric HIV burden than current statistics, including the first-ever global estimates of new HIV infections among young adolescents, as well as insight into the unique contributions of biomedical, behavioral, and structural factors on the burden of HIV/AIDS in children and young adolescents. We will do so by assembling and triangulating data sources; quantifying the relationship between risk and protective factors and child/adolescent HIV burden; and forecasting the future burden of HIV among children/adolescents through 2040 based on current trends in incidence, prevalence, and mortality, and exposure to risk and protective factors.

PI_NAMEs: KYU, HMWE HMWE (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adolescent;Adult;Adult women;African;Age;age group;antiretroviral therapy;Automobile Driving;Behavioral;Big Data;Birth;burden of illness;Caring;Cessation of life;Child;Childhood;condoms;Consensus;Country;Data;Data Sources;diverse data;Education;Epidemic;Exposure to;Fibrinogen;Future;Goals;Health;health care quality;HIV;HIV Infections;HIV-infected adolescents;HIV/AIDS;Human immunodeficiency virus test;Incidence;Infection;insight;interactive visualization;Intervention;Link;Location;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;pediatric human immunodeficiency virus;Policies;Population;Prevalence;Prevention;Probability;protective factors;rate of change;Risk;Risk Behaviors;Risk Factors;Role;Series;sex;Sex Behavior;sexual debut;Sexual Partners;Source;statistics;structural determinants;Substance abuse problem;Time;tool;transmission process;trend;Vertical Disease Transmission;Visualization software;Work

PROJECT_TITLE: Quantification of HIV burden and the biomedical, structural, and behavioral factors influencing HIV/AIDS among children and young adolescents

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Regulation of lipid production and degradation is a critical part of cellular health with defects in this process associated with aging and Alzheimer’s disease (AD). However, mechanistic understanding into the function of AD risk genes that are involved in the uptake and breakdown of lipids remains elusive. Here, we systematically probe the impact of AD risk genes involved in these processes using Drosophila models of lipid droplet formation and neurodegeneration.

PI_NAMEs: BELLEN, HUGO J;BOTAS, JUAN ;SHULMAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Affect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;apolipoprotein E-4;Biological Process;Brain;Candidate Disease Gene;cell type;Cells;Defect;Disease;Disease susceptibility;Dissection;Drosophila genus;experimental study;functional genomics;Funding;Genes;Health;high throughput screening;Homeostasis;Human;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;Injury;Investigation;Joints;Lipid Peroxidation;Lipids;Manuscripts;Modeling;Nerve Degeneration;Neuroglia;Neurons;neuroprotection;Oxidative Stress;Pathologic;Pathway interactions;Process;Production;programs;Protocols documentation;Reactive Oxygen Species;Regulation;Research;Research Personnel;response;risk variant;Stress;Susceptibility Gene;Tauopathies;therapeutic target;uptake

PROJECT_TITLE: Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models


NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL

PI_NAMEs: MCCORMICK, DAVID L. (contact)

PROJECT_TERMS: anti-cancer therapeutic;Antibodies;Canis familiaris;Clinical Trials;Development;Malignant Neoplasms;method development;Pharmaceutical Preparations;pre-clinical;Qualifying;safety study;Sampling;Testing;Toxicology

PROJECT_TITLE: PRECLINICAL TOXICOLOGY OF LARGE MOLECULE DRUGS DEVELOPED FOR CANCER AND OTHER AND OTHER INDICATIONS  INDICATIONS


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Nearly 20 million older adults undergo major elective surgical procedures, yet very few receive advance care planning (ACP). Patients and/or caregivers must make complex decisions, but many are unprepared to articulate individual care goals and consequently, older adults may undergo surgical and post-surgical treatments inconsistent with their values and goals. We will conduct a three arm pragmatic randomized controlled trial, leveraging the electronic health record, in 3 geographically distinct healthcare systems to determine the effectiveness of increasing support intensity with improving ACP completion rates and increasing patient engagement with ACP (measured by survey).

PI_NAMEs: MELTON-MEAUX, GENEVIEVE B;SUDORE, REBECCA L;WICK, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Adoption;Advance Care Planning;advanced directive;arm;Articulation;Biometry;care episode;Caregivers;Caring;Cessation of life;Clinic;Clinical;Clinical Trials;Collaborations;Colonoscopy;Communication;Complex;data mining;Data Science;Decision Making;Dedications;design;digital intervention;digital tool;Documentation;Effectiveness;effectiveness evaluation;Elective Surgical Procedures;Electronic Health Record;empowerment;end of life;Ensure;Evaluation;evidence base;experience;Familiarity;Foundations;Functional impairment;Geography;Geriatrics;Goals;Guidelines;handheld mobile device;Health;Health behavior;Health Services;Health Status;Health system;Healthcare;Healthcare Systems;Home;Human;human old age (65+);Impairment;implementation science;improved;Individual;Informatics;Infrastructure;innovation;Intervention;Letters;Mammography;Measures;Medical;medical schools;Methods;Modality;Modeling;Natural Language Processing;novel;older adult;Operative Surgical Procedures;Outcome;Outcome Measure;Patient Care Planning;patient engagement;patient oriented;patient portal;Patients;Persons;Phase;Physicians;pilot test;Population;preference;Preparation;primary outcome;programs;Randomized;Randomized, Controlled Trials;remote health care;Reporting;Research;Resources;San Francisco;Societies;Surgeon;surrogate decision maker;Surveys;System;Technology;Telephone;Testing;Text;theories;Time;tool;Training;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;virtual healthcare;web site;Work

PROJECT_TITLE: I CAN DO Surgical ACP (Improving Completion, Accuracy, and Dissemination Of Surgical Advanced Care Planning) Trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Albany

ORG_NAME: REGENERATIVE RESEARCH FOUNDATION

ORG_STATE: NY

PHR: PROJECT NARRATIVE In Alzheimer’s disease, brain cells are unable to absorb or degrade molecules properly, leading to abnormal accumulation of lipids and toxic proteins and thus to cell death and impaired memory and cognition. Today, we do not yet have a full accounting of the molecules involved in these processes, nor how they act within specific types of brain cells. Here, we propose to perform a large-scale screen to identify the molecules responsible in brain and vascular cells. We will then perform in-depth functional studies to define how these molecules act in the brain and uncover effective ways to prevent the progression of Alzheimer’s disease.

PI_NAMEs: KAMPMANN, MARTIN ;TEMPLE, SALLY  (contact)

PROJECT_TERMS: 3-Dimensional;absorption;Accounting;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Applications Grants;Astrocytes;Biological Assay;Biological Models;Blood - brain barrier anatomy;Blood Vessels;BODIPY;Brain;brain cell;Candidate Disease Gene;candidate identification;Cell Death;Cell model;Cell Physiology;cell type;Cells;Cerebral cortex;Cognition;Collaborations;combat;CRISPR interference;CRISPR screen;Data;Data Set;data sharing;Development;Drosophila genus;Early Intervention;electric impedance;Endothelial Cells;follow-up;Follow-Up Studies;functional outcomes;Gene Expression;Gene Targeting;Genes;genome wide association study;Glutamates;Guide RNA;Health;high throughput screening;Homeostasis;Human;human induced pluripotent stem cells;Impairment;Incidence;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;Influentials;insight;knock-down;Libraries;Light;lipid metabolism;Lipids;Location;LysoTracker;Measures;Memory impairment;Microglia;Modeling;Molecular;monolayer;neurofilament;Neurons;neurovascular;novel;Organoids;Pathology;Pathway interactions;Pericytes;Phenotype;Play;prevent;Process;Productivity;Proteins;Recycling;risk variant;RNA library;Role;System;targeted treatment;tau Proteins;tau-1;Technology;therapy development;Time;uptake;Validation;Variant;Vascular Endothelial Cell;Vesicle;Work

PROJECT_TITLE: Identification of AD-risk genes affecting endolysosomal and lipid homeostasis pathways


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Strategies for promoting healthy brain aging and preventing/delaying Alzheimer's disease are needed in adults with Down Syndrome (DS), a population at high risk of developing Alzheimer’s disease. The promotion of weight loss and improvements in diet quality in adults with DS may improve cognitive function and prevent or delay Alzheimer’s disease.

PI_NAMEs: PTOMEY, LAUREN TAYLOR (contact);SULLIVAN, DEBRA K

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Adult;Age;Age Years;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Antioxidants;arm;Behavioral;Beverages;Biological Markers;Body Weight Changes;Body Weight decreased;brain volume;Calories;Carotenoids;Cause of Death;Cerebrum;Chromosome abnormality;Chronic;clinic ready;clinical trial readiness;Clinical Trials;clinically relevant;Cognition;cognitive function;Consumption;Counseling;DASH diet;Data;Databases;Dementia;Development;Diet;Dietary intake;Dietary Intervention;Dietary Practices;Down's Syndrome;Education;Educational Curriculum;Food;Food Energy;fruits and vegetables;Glial Fibrillary Acidic Protein;Goals;Health education;High Prevalence;high risk;Impact evaluation;improved;Incidence;Individual;Institutional Review Boards;Intake;Intellectual functioning disability;Intervention;lifestyle intervention;Light;Macronutrients Nutrition;Magnetic Resonance Spectroscopy;Manuals;meter;Monitor;multi-component intervention;Nerve Degeneration;neurofilament;Obesity;Outcome;Outcome Assessment;Overweight;Oxidative Stress;Participant;Pathology;Patient Recruitments;Phase;Physical activity;pilot trial;Plasma;Population;Prevalence;prevent;Procedures;Proteins;Randomized;Recommendation;Records;response;saturated fat;Skin;System;tau-1;Time;Training;treatment arm;Weight maintenance regimen

PROJECT_TITLE: The Impact of Weight Loss on Alzheimer's Disease Risk in Adults with Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(90)S]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: Narrative The proposed research is relevant to public health because it tests how stressors across the life course— including harsh conditions in early life and challenging social circumstances in adulthood—predict autonomic stress responses and cardiometabolic measures of health. The project validates insertable cardiac monitors for measuring autonomic stress responses in captive non-human primates, and then use this validation to measure autonomic activity in a natural population in response to real-time, longitudinal data on adversity in early life and adulthood. This natural population offers fine-grained data and a simplified model, without the complexities of human health risk behaviors. The project is highly relevant to NIA’s mission of understanding aging processes across the life course by testing how repeated social and environmental stressors cause over-activation of the stress response, as a driver of accelerated aging.

PI_NAMEs: ARCHIE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Accelerometer;Acute;acute stress;Adult;Affect;age acceleration;Aging;aging process;aging related disease;Animal Model;Animals;Autonomic nervous system;biological adaptation to stress;Biological Assay;Calibration;Cardiac;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder risk;Chronic;Chronic stress;cost;Data;Diabetes Mellitus;Dimensions;disorder risk;doubly-labeled water;drivers of aging;early life adversity;Electrocardiogram;Energy Metabolism;environmental stressor;Event;Face;Famines;Glucocorticoids;Goals;Grain;Health;Heart Diseases;Heart Rate;heart rate variability;Hour;Human;hypothalamic-pituitary-adrenal axis;Implant;Individual;Kenya;Lead;Life;Life Cycle Stages;Life Experience;life span;Link;Lived experience;Longitudinal Studies;Measures;Mediating;Metabolic;Metabolism;Mission;Modeling;Monitor;mortality;neglect;Neurosecretory Systems;nonhuman primate;obesity risk;Papio;Physical activity;Physiology;Population;Poverty;Primates;Prognostic Marker;prospective;Proxy;psychosocial;Public Health;Recovery;Research;response;Rest;Risk Behaviors;Shapes;social;social adversity;Social Conditions;Social Environment;Social isolation;social stressor;Stress;stressor;Testing;Time;tool;Validation;Walking;Work

PROJECT_TITLE: Developing insertable cardiac monitors to assess social and environmental effects on the autonomic stress response in a nonhuman primate model of aging


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative Animal species differ dramatically in longevity and susceptibility to age-related diseases. This Project identifies genetic and epigenetic mechanisms responsible for extended healthspan and lifespan in long-lived bats experiencing social stress. This knowledge will enable the development of interventions to delay the onset of aging and age-related diseases in humans.

PI_NAMEs: WILKINSON, GERALD S (contact)

PROJECT_TERMS: Address;Adult;Age;age related;age-related disease;Aging;aging biomarker;aging mechanism;aging related;Animals;Bioinformatics;Biological Assay;bisulfite sequencing;Body Size;Chiroptera;Complex;CpG Islands;Cross-Sectional Studies;Data;Data Analyses;Distant;DNA Methylation;DNA methylation profiling;Epigenetic age;epigenetic aging;Epigenetic Process;Exhibits;experience;Family;father role;Fathers;Female;Food;Gene Expression;Genetic;Genome;genomic biomarker;Goals;hallmarks of aging;Health Status;healthspan;Human;Immune;immune function;Immune response;Immunity;Immunologic Tests;Individual;Knowledge;Lactation;Leukocytes;life span;Lipopolysaccharides;Location;Longevity;Longitudinal Studies;male;Mammals;Measures;member;Methods;Mononuclear;Mus;Natural experiment;Natural Immunity;Nose;Partner in relationship;Peripheral;Phase;Population;Predisposition;reproductive;Reproductive Periods;reproductive success;Seasons;sex;Sex Differences;Site;social;Social Behavior;social group;social integration;Social Network;social situation;Social status;social stress;System;Tail;Testing;therapy development;Variant;Virus;whole genome;Women's Group

PROJECT_TITLE: Social stress, epigenetics and immune function across bat lifespans


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Cancer is defined by an accumulation of genetic variants that drive tumor growth and metastasis. With the ongoing development of therapies that target specific deregulated molecular pathways, it is increasingly important to understand the connections between genetic variants and the diagnosis, prognosis, and treatment response of cancers. In this project, the ClinGen Somatic Knowledgebase and UniProt data resources will collaborate on AI-driven data strategies, including the use of Large Language Models (LLMs), to extract information about cancer variants from the scientific literature at large scale and make it accessible to researchers and clinicians for precision medicine.

PI_NAMEs: GRIFFITH, MALACHI  (contact);GRIFFITH, OBI L.

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adopted;annotation  system;artificial intelligence model;Automated Abstracting;Bibliography;cancer genome;cancer type;Classification;Clinical;clinically relevant;clinically significant;Collaborations;Communities;Consumption;crosslink;Data;data curation;data repository;data resource;Databases;Dedications;Diagnosis;Diagnostic;digital;Disease;evidence base;experience;Funding;Generations;Genes;Genetic Diseases;genetic variant;Hallucinations;improved;Information Retrieval;interest;Internet;Journals;Knowledge;knowledgebase;large language model;Level of Evidence;Literature;Malignant Neoplasms;Manuals;Maps;meetings;member;Methodology;Modeling;Molecular;natural language;Natural Language Processing;Natural Language Processing pipeline;Neoplasm Metastasis;neoplasm resource;Oncogenic;Paper;Pathogenicity;Pathway interactions;Performance;Pharmaceutical Preparations;precision medicine;Production;Prognosis;prognostic;programs;prompt engineering;prototype;Research Personnel;Resources;response;Retrieval;Role;scale up;Somatic Mutation;Structure;synergism;System;targeted treatment;Technology;Text;text searching;therapy development;Time;tool;Training;treatment response;Triage;tumor growth;United States National Institutes of Health;user-friendly;Validation;Variant;web app;Work;working group;Writing

PROJECT_TITLE: Text Mining and Large Language Models for AI-Driven Evidence-Based Functional Annotation of Clinical Variants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Immunization;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE | 5R35NS111644 | Administrative Supplement Multiple sclerosis is a common and disabling autoimmune disease of the central nervous system in which B cells play a central pathogenic role. The principal goal of the project is to identify the disease trigger(s), and to understand the mechanisms underlying disease progression. Central elements of this initiative include large well-characterized clinical populations, comprehensive biobanked materials, serial magnetic resonance imaging of the brain and spinal cord using novel quantitative techniques, complete genetic information, and state of the art tools to investigate B cell biology including single cell B cell transcriptomics, recombinant antibody libraries, and phage-displayed synthetic protein arrays to identify antibody reactivities against foreign and self proteins.

PI_NAMEs: HAUSER, STEPHEN L (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Administrative Supplement;Affect;Antibodies;antibody libraries;Axon;B-Lymphocytes;biobank;Brain imaging;Cells;Cellular biology;Cerebrospinal Fluid;Chronic;chronic autoimmune disease;Clinical;CNS autoimmune disease;cohort;Data;Disabling;Disease;Disease Progression;Elements;Fingerprint;Genetic Determinism;genetic information;Goals;Human;improved;Individual;Inflammation;information organization;Magnetic Resonance Imaging;Mediating;microbial;Molecular;Multiple Sclerosis;Myelin;Neurologic Dysfunctions;Neurons;novel;Oligodendroglia;Onset of illness;Pathogenicity;Pathology;Patient-Focused Outcomes;Patients;peripheral blood;Phage Display;Pharmaceutical Preparations;Play;Population;Progressive Disease;Protein Array;Proteins;receptor;Recombinant Antibody;Research;Role;screening;Serial Magnetic Resonance Imaging;Serum;Spinal Cord;synthetic protein;Techniques;Technology;Therapeutic;Time;tool;transcriptomics;United States;Viral

PROJECT_TITLE: The Role of B cells in the Origin and Progression of Multiple Sclerosis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: In this study, we will culture human PAX7::GFP+ skeletal muscle stem/progenitor cells on aligned, electrospun fibrin microfiber bundles to induce their fusion into myotubes and assembly into 3D skeletal muscle grafts. We will optimize the delivery of soluble and tethered agrin in combination with insulin-like growth factor-1 (IGF-1) to promote the growth and myogenic differentiation of PAX7::GFP+ cells. Subsequently, we will use skeletal muscle grafts engineered with and without soluble and tethered agrin/IGF-1 to promote neuromuscular regeneration and functional recovery in a murine model of volumetric muscle loss.

PI_NAMEs: GRAYSON, WARREN L (contact);LEE, GABSANG

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Action Potentials;Agrin;Binding;Biocompatible Materials;Biophysics;Blood Vessels;Cell Aggregation;cell growth;Cell Survival;Cell Therapy;Cells;Cellular Morphology;Cholinergic Receptors;Clinical;Data;Defect;Development;Economic Burden;effective therapy;Electrospinning;Engineering;Fiber;Fibrin;Fibrosis;Functional Regeneration;functional restoration;Gene Expression Profile;Genes;Genetic;Growth;Harvest;Heparan Sulfate Proteoglycan;Heterogeneity;Human;human pluripotent stem cell;immunodeficiency;Immunodeficient Mouse;Implant;In Vitro;in vivo;Individual;Infiltration;Injury;Insulin-Like Growth Factor I;Intercept;Kinetics;lean body mass;Modulus;monolayer;Morphology;Motor Neurons;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;muscle engineering;Muscle Fibers;muscle grafts;muscle physiology;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Myoblasts;myogenesis;Natural regeneration;Nerve;neural;neuromuscular;Neuromuscular Junction;neurotransmission;novel;Phenotype;Play;Population;Porosity;post-transplant;postsynaptic;Preparation;Prevention;progenitor;Proliferating;Property;Recovery of Function;regeneration potential;Regenerative capacity;reinnervation;repaired;Reporter;Role;scaffold;scale up;single-cell RNA sequencing;Site;Skeletal Muscle;Sorting;stem;stem cell biology;stem cells;Surgical incisions;Testing;tibialis anterior muscle;Tissue Engineering;Transplantation;Traumatic injury;Treatment Protocols;Vascularization;volumetric muscle loss

PROJECT_TITLE: Regenerating Vascularized and Innervated Skeletal Muscle to Treat VML Defects

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;National Institute of Allergy and Infectious Disease;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - NIAID - Miambo


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Immunotherapy

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: NARRATIVE The overall goal of this project is to establish the association of genetic polymorphism of the NK (natural killer) cell receptome in human populations. NK receptors are critical for innate immunity against tumors and are encoded by the highly polymorphic Leukocyte Receptor Complex (LRC, Chr 19) and Natural Killer Complex (NKC, Chr 12). To address our goals, we will deeply sequence the LRC and NKC in 18 ancestrally diverse human populations and leverage our expertise in bioinformatic analysis to integrate genetic data with single-cell transcriptome sequencing to search for expression quantitative trait loci (eQTL) markers.

PI_NAMEs: AUGUSTO, DANILLO G (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 19q13;Address;African;African American population;Alleles;American;Amerindian;Bioinformatics;bioinformatics pipeline;Bolivia;C Type Lectin Receptors;cancer cell;Cells;Characteristics;Chromosome 19;Code;Complex;Comprehension;Copy Number Polymorphism;Custom;cytotoxicity;Data;design;differential expression;Disease;DNA;Elements;European;Exhibits;experience;Future;Gene Cluster;Gene Expression Regulation;Gene Family;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genetic Variation;genome wide association study;Genomic Segment;genomic variation;Genotype;Germ Cells;Goals;Homologous Gene;Human;Immune response;Immunoglobulins;Individual;Infection;innovation;Killer Cells;Leukocytes;Linkage Disequilibrium;Malignant Neoplasms;Maps;Medical;Mononuclear;Native Americans;Natural Immunity;Natural Killer Cell Immunotherapy;Natural Killer Cells;Natural Selections;next generation sequencing;novel;Paraguay;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Peru;Population;Population Genetics;Quantitative Trait Loci;receptor;Receptor Cell;Role;Sampling;segregation;single cell sequencing;single-cell RNA sequencing;South Africa;South America;South Asian;synergism;transcriptome;transcriptome sequencing;Translating;tumor;Validation;Variant;Work

PROJECT_TITLE: Defining Variation in the Natural Killer Cell Receptome in Human Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]