ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE  This proposal aims to design proteins with high precision that can tightly and selectively bind to any small- molecule ligand. By designing small-molecule-binding proteins from scratch, this project aims to i) test and extend our understanding of the essential ingredients used by proteins for molecular recognition, ii) obtain atomic-level control of the protein/small-molecule interface, and iii) set the stage for the development of proteins that could serve as novel sensors, enzymes, drug delivery vehicles, or pharmaceuticals.

PI_NAMEs: POLIZZI, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Achievement;Affinity;Agreement;Algorithm Design;Amino Acid Sequence;Amino Acids;Amino Acyl-tRNA Synthetases;Anticoagulants;Antidotes;Antithrombin III;Award;base;Binding;Binding Proteins;Binding Sites;Charge;Clinical;clinical application;clinically relevant;Coagulation Process;Collaborations;combinatorial;Complement;Complex;Computer Models;Computing Methodologies;Crystallization;data repository;Databases;delivery vehicle;design;Development;Drug Delivery Systems;Enzymes;Event;Evolution;Fibrinolytic Agents;functional group;Geometry;Goals;Health;Heterogeneity;Human;Hydrogen Bonding;Hydrophobicity;Individual;infancy;insight;Knowledge;Laboratories;Learning;Libraries;Life;Ligands;Ligase;Mammalian Cell;Mediating;Medical;meetings;Methods;model design;Modernization;Molecular Biology;Molecular Conformation;molecular dynamics;Molecular Probes;molecular recognition;Motivation;Mutagenesis;mutant;Nature;novel;Pharmaceutical Preparations;Pharmacologic Substance;phosphohistidine;Phosphoserine;Physicians;Play;porphyrin a;Porphyrins;Post-Translational Protein Processing;Principal Investigator;Process;Productivity;professor;programs;protein data bank;Protein Engineering;protein folding;protein function;protein protein interaction;Protein Structure Databases;Proteins;Publications;pyrrolysine;Recording of previous events;Research;Resolution;Roentgen Rays;Role;Sampling;Schedule;Scientist;screening;sensor;Set protein;skills;small molecule;Specificity;Structure;success;System;Temperature;Testing;thrombotic;Time;Training;tyrosine O-sulfate;unnatural amino acids;Variant;Vertebral column;Water;water sampling;Work;X-Ray Crystallography

PROJECT_TITLE: De novo design of small-molecule-binding proteins


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Combining immunotherapies with other cancer drugs has emerged as a new hope for late-stage cancer patients, however, the lack of a principled approach to identify such effective combinations often led to poorly designed clinical trials. The proposed research engages state-of-art Artificial Intelligence techniques with drug-induced transcriptomic changes to identify drugs that synergize with immunotherapies and prioritize them for clinical trials. Its application, as well as the career development pursued by the investigator, will rationalize clinical trials, identify new treatments for advanced cancers, and advance precision immuno-oncology.

PI_NAMEs: SAHU, AVINASH DAS (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;Advisory Committees;Aftercare;Antibodies;Antigen Presentation;Antineoplastic Agents;Area;Artificial Intelligence;Award;Biological;Biological Markers;Biology;BRAF gene;cancer cell;cancer clinical trial;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;career;career development;CD8B1 gene;Cell Line;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Cloud Computing;cohort;Collaborations;combination cancer therapy;Combination immunotherapy;Combined Modality Therapy;Computational Biology;Computer software;computing resources;Data;data access;Data Commons;deep learning;design;Development Plans;Doctor of Philosophy;Drug Combinations;Drug Synergism;Drug usage;Effectiveness;Environment;Foundations;Goals;Human;Immune;immune checkpoint blockers;immune modulating agents;Immune system;Immunologic Factors;Immunological Models;Immunology;Immunology procedure;Immunooncology;immunoregulation;Immunotherapy;improved;in silico;In Vitro;in vivo;industry partner;Infiltration;Infrastructure;inhibitor;innovation;Investigational Drugs;K-Series Research Career Programs;Knowledge;large datasets;Learning;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Melanoma;Mentors;method development;Mission;mouse model;novel;novel therapeutic intervention;Outcome;palliative chemotherapy;Patients;Performance;Pharmaceutical Preparations;Phase;Pre-Clinical Model;precision oncology;predicting response;Prize;prototype;Rationalization;Renal Carcinoma;Research;Research Personnel;response;response biomarker;skills;small molecule;software infrastructure;sound;statistics;synergism;Target Populations;Techniques;Technology;Testing;Training;Training Activity;training data;transcriptome;transcriptome sequencing;transcriptomics;transfer learning;Translational Research;Translations;treatment optimization;tumor;tumor immunology;tumor-immune system interactions;Vaccines;Work

PROJECT_TITLE: Identifying drug synergistic with cancer immunotherapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The computer vision technologies and machine learning methods applied in this grant will facilitate a precision medicine approach for nephrotic syndrome patients through automated histologic assessment of renal biopsies and comprehensive characterization of kidney structure, function, and molecular endophenotypes. The computational pathology framework and understanding of biology and disease trajectory will serve as a support tool to guide pathologists and nephrologists in kidney research, clinical trials, and clinical care for proteinuric glomerulonephropathies.

PI_NAMEs: BARISONI, LAURA MARIACHIARA (contact);HODGIN, JEFFREY BENTON;HOLZMAN, LAWRENCE B.;ZEE, JARCY

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Area;Artificial Intelligence;biobank;Biological;Biological Markers;Biology;biomarker identification;biomarker signature;Blood Vessels;Categories;Characteristics;Classification;Clinical;clinical care;Clinical Data;clinical phenotype;Clinical Trials;cohort;Collaborations;Communities;Computer Vision Systems;Data;Data Set;deep learning;Detection;Diagnosis;Diagnostic;digital;Digital biomarker;Disease;disease heterogeneity;disease natural history;Disease Outcome;effective intervention;endophenotype;experience;Focal and Segmental Glomerulosclerosis;Foundations;Gene Expression;Goals;Grant;Histologic;Human;Image Analysis;Imaging Techniques;Impairment;improved;Individual;individual patient;Kidney;kidney biopsy;Kidney Failure;Machine Learning;machine learning method;machine learning model;machine vision;Methodology;Methods;Minority Groups;Molecular;molecular phenotype;Molecular Profiling;Morphology;multidimensional data;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrotic Syndrome;next generation;novel;novel therapeutic intervention;Outcome;outcome prediction;Pathologist;Pathology;patient biomarkers;Patient-Focused Outcomes;Patients;Pattern;Phenotype;precision medicine;predict clinical outcome;Predictive Value;profiles in patients;prognostication;programs;prospective;Recording of previous events;Renal glomerular disease;Research;Resources;Risk Factors;Shapes;spatial relationship;Structure;Subgroup;support tools;System;Technology;Testing;Texture;therapeutically effective;Tissues;tool;treatment response;United States National Institutes of Health;Visual;whole slide imaging;Work

PROJECT_TITLE: Computational Pathology of Proteinuric Diseases

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: FORT WORTH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative Tumor-derived exosomes are mediators of aggressive distant metastasis by contributing to the establishment of a pre-metastatic niche. Therefore, it is critical to investigate the molecular mechanism(s) that drive tumor- derived exosome-mediated immune modulation and pre-metastatic niche formation for aggressive metastasis in TNBC. Furthermore, determining the mechanisms that drive the aggressive metastasis in TNBC will lead to developing novel therapeutic strategies.

PI_NAMEs: CHAUDHARY, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Accounting;Actins;Affect;African American Women;American;angiogenesis;Annexins;Biological Models;Biology;Body Fluids;bone;Brain;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Patient;cancer health disparity;cancer subtypes;caucasian American;CD8-Positive T-Lymphocytes;Cell Adhesion;Cell Line;clinical translation;Communication;comorbidity;cytokine;Cytoskeleton;cytotoxic CD8 T cells;Data;Death Rate;Depressed mood;Detection;Disease;Disease-Free Survival;Disparity;Distant;Distant Metastasis;Endocytosis;Exocytosis;exosome;extracellular;Extracellular Matrix;extracellular vesicles;Frequencies;Goals;Growth Factor;health care availability;health care disparity;humanized mouse;IL6 gene;Immune system;immunoregulation;improved;In Vitro;in vivo;in vivo evaluation;intercellular communication;Literature;Liver;Location;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;MAP Kinase Gene;Measures;Mediating;Mediator;Membrane;migration;Molecular;mouse model;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Non-Malignant;novel;novel therapeutic intervention;Nucleic Acids;Organ;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Peptides;peripheral blood;Plasminogen;Play;Population;Prevention;Process;Prognosis;prognostic;Proteins;Publishing;Race;Regulatory T-Lymphocyte;Research;Role;Sampling;Serum;Site;small hairpin RNA;socioeconomics;STAT3 gene;stem;Stromal Cells;T-Lymphocyte;Therapeutic;therapeutic target;therapeutically effective;Tissues;TNF gene;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;tumor;Tumor Necrosis Factor Ligand Superfamily Member 6;Tumor Tissue;Tumor-Derived;tumorigenesis;Woman

PROJECT_TITLE: Emerging role of tumor-derived exosomes in immune modulation and breast cancer health disparity.

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Genome-wide association studies have identified a wealth of non-coding regions in the human genome associated with human health. A goal of these studies is an improved understanding of the etiology of the disease and the construction of animal models that precisely mimic the human condition. Towards these efforts, we will construct maps of non-coding regions between mouse and human that share similar functions, which will transform our ability to develop better organismic models of human disease.

PI_NAMEs: TEWHEY, RYAN  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Acceleration;Alleles;Animal Model;Automobile Driving;Binding;Biological Assay;causal variant;Cells;chromatin modification;comparative;Complex;CRISPR screen;Deoxyribonucleases;Development;direct application;Disease;disorder risk;Elements;Encyclopedia of DNA Elements;Enhancers;Epithelium;Etiology;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genetic Variation;Genome;genome wide association study;genome-wide;Goals;Health;Heritability;Human;human disease;Human Genome;human induced pluripotent stem cells;human model;Hypersensitivity;improved;Individual;insight;Location;Maps;Measurement;Measures;Methods;model organism;Molecular;molecular phenotype;Mus;Mutagenesis;Neurons;Phenotype;Physiological;Population;Regulatory Element;Reporter;Screening Result;Sequence Homology;success;trait;Untranslated RNA;Variant;Writing

PROJECT_TITLE: Functional Mapping of Enhancer Conservation Between Species to Enable Mechanistic Insights into Polygenic Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Prevention;Sleep Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative To interrupt the cycle of obesity that runs in families, it is important to identify early and modifiable risk factors that affect infants’ appetite. This study proposes that maternal and infant sleep and circadian rhythms influence infant appetite development and may be targeted to reduce obesity risk in the first year of life. Thus, studying how maternal-infant sleep and circadian rhythm patterns are associated with infant appetite, and how they together impact infant weight gain, will inform (1) our understanding of behavioral factors related to intergenerational obesity risk transmission, and (2) our development of critically needed behavioral interventions that effectively reduce obesity risk and promote cardiometabolic health among infants, women, and families.

PI_NAMEs: CONLON, RACHEL P. KOLKO (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;Adult;Affect;Applications Grants;approach behavior;avoidance behavior;behavior change;Behavior Therapy;Behavioral;Biological Clocks;Birth;Body mass index;Body Weight;cardiometabolism;Child;Childhood;circadian;Circadian Rhythms;critical period;Darkness;Data;design;Desire for food;Development;Early identification;Eating;effective intervention;Ensure;Family;feeding;Feeding Patterns;Female;Food;food avoidance;Health;Hour;Individual;infancy;Infant;infant adiposity;Infant Food;innovation;intergenerational;Interruption;Intervention;Life;life span;Light;Link;Measures;Methodology;Methods;Modeling;modifiable risk;Mothers;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;obesity risk;obesity treatment;Outcome;Parents;Patient Self-Report;Pattern;Persons;Physiological;Population;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prepregnancy;pressure;prevent;programs;prospective;rapid infant weight gain;rapid weight gain;recruit;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Rest;Risk Factors;Role;Running;Satiation;Science;Sleep;Sleep disturbances;Solid;Standardization;Strategic Planning;Strategic vision;sucking;System;therapeutic target;therapy development;Third Pregnancy Trimester;Time;trait;transmission process;United States National Institutes of Health;Weight;Weight Gain;Woman

PROJECT_TITLE: Identifying mechanisms of maternal-infant obesity risk transmission: The role of appetite, sleep, and circadian rhythms

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chronic kidney disease is a significant and growing public health problem that currently affects an estimated >37 million Americans. The NIDDK-sponsored prospective Chronic Renal Insufficiency Cohort (CRIC) Study was established to identify factors leading to worsening of chronic kidney disease and to understand the complex relationship between kidney dysfunction, cardiovascular disease, death, and other clinical and patient- centered outcomes. The overall purpose of the proposed renewal of the Kaiser Permanente Northern California/University of California, San Francisco CRIC Clinical Center is to complete follow-up of its existing Phase 4 participants as part of the anticipated overall eligible CRIC cohort of >2100 adults with chronic kidney disease, with a focus on ascertaining clinical outcomes, creating mechanisms for future data collection and analyses, and generating tools and resources to facilitate ongoing use of CRIC data and biospecimens by the broader scientific community during and beyond the final phase of the CRIC Study.

PI_NAMEs: GO, ALAN S (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adult;Affect;American;Ancillary Study;Arrhythmia;Biological;California;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;cohort;Cohort Studies;Collaborations;Communities;Complex;Data;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data integration;data quality;Data Sources;design;Disease Progression;Eligibility Determination;eligible participant;Enrollment;Ensure;Epidemiology;epidemiology study;Event;experience;follow-up;Funding;Future;Goals;health data;Home;home test;improved;innovation;Institution;Investigation;Kidney Diseases;kidney dysfunction;Kidney Function Tests;Leadership;Measures;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational epidemiology;Outcome;Output;Parents;Participant;participant enrollment;Patient-Focused Outcomes;Phase;Phenotype;phenotypic data;Physiological;Process;Productivity;programs;prospective;Prospective cohort;Prospective Studies;Protocols documentation;Public Health;recruit;renal damage;Renal function;repository;Research;Research Personnel;Resources;Risk;Risk Factors;San Francisco;Science;Severity of illness;social;Source;Specimen;success;tool;Translational Research;Universities;Visit

PROJECT_TITLE: Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Deep crypt secretory cells are important for maintaining colonic homeostasis and express a class of proteins— host defense peptides—known to be dysregulated in intestinal inflammatory disease. The studies proposed will advance our understanding of the role and regulation of these cells and their secreted factors in colitis, and will lead to new therapeutic targets for human health.

PI_NAMEs: SCHUMACHER, MICHAEL ANDREW (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Advisory Committees;Affect;Area;Automobile Driving;Award;base;Biology;career;career development;Cell Count;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular biology;Chronic;Colitis;Colon;colonic crypt;cytokine;Data;design;Development;Development Plans;Doctor of Philosophy;Epithelial Cells;Epithelium;experimental study;Foundations;Funding;gain of function;Goals;healing;Health;Homeostasis;Host Defense;Human;Immune;immune activation;immune function;Immune response;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;inhibitor;insight;Institution;Interleukin-13;intestinal epithelium;Intestines;K-Series Research Career Programs;Knockout Mice;loss of function;Mentors;Modeling;mouse model;Mus;new therapeutic target;Organoids;Pathway interactions;Patients;Peptides;pharmacologic;PIK3CG gene;Population;Principal Investigator;Production;progenitor;Proteins;Recovery;Regulation;Repression;Research;research and development;Research Personnel;Resistance;response;Role;Secretory Cell;Severities;Shapes;Signal Transduction;Source;spatiotemporal;stem;Testing;therapeutic target;tool;Training;transcriptomics;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: The role and regulation of deep crypt secretory cells in colitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Hercules

ORG_NAME: X-THERMA INC.

PHR: Project narrative Organ preservation, storage, and transport technology is of paramount importance to the field of organ transplant and plays a lifesaving role, yet organ transplantation still suffers from very narrow time windows for organ transport. If preservation techniques could be sufficiently advanced, more time would be available to improve the allocation of donated organs leading to reduced geographic restriction, faster patient recovery, drastically shorter hospital stays, and greatly diminished healthcare costs – all while tackling the biggest challenge of all – to increase the amount of available organs for transplant and improve patient outcomes. This proposal aims to further develop organ storage technology to extend the time with which kidneys can be transported and successfully transplanted.

PI_NAMEs: BRANDACHER, GERALD ;KLINE, MARK A (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Animal Model;Animals;Autologous Transplantation;Back;Biological Markers;Blood Chemical Analysis;Blood donor;Breakthrough device;Chemicals;Chemistry;Clinical;clinically relevant;Collaborations;commercialization;Complete Blood Count;cost;Creatinine;Cryopreservation;Data Set;Dimethyl Sulfoxide;Evaluation;Family suidae;Flushing;Formulation;Funding;Geography;Goals;Health Care Costs;Histology;Human;Immunohistochemistry;improved;improved outcome;in vivo;Injury;Injury to Kidney;innovation;Investigation;Ischemia;Kidney;kidney allograft;kidney preservation;Kidney Transplantation;Length of Stay;Life;Logistics;Marketing;medical schools;Methods;Miniature Swine;Modality;Modeling;Monitor;next generation;novel;Organ;Organ Preservation;Organ Preservation Solutions;Organ Size;Organ Transplantation;Patient-Focused Outcomes;Patients;Peptoids;Perfusion;Phase;Play;post-transplant;Postoperative Period;pre-clinical;preservation;Preservation Technique;Process;Production;Property;Proteins;Protocols documentation;Recommendation;Recovery;Recovery of Function;Renal Blood Flow;Renal function;Reperfusion Therapy;Rewarming;Role;Serum;Small Business Innovation Research Grant;success;Surgeon;System;Technology;Temperature;Testing;Time;Tissue Preservation;Tissue Viability;Toxic effect;Translating;transplant model;Transplantation;Universities;Urine;Weight;Wisconsin;Work

PROJECT_TITLE: Greatly Extended Subzero Ischemic Storage of Renal Allografts Using Novel Bio-inspired Next Generation Cryoprotectants


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) represents the major cause of morbidity and mortality in diabetic subjects with insulin resistance. In these studies, we will examine whether a novel drug may be effective at attenuating atherosclerosis by burning fat, reversing hyperinsulinemia/insulin resistance and reducing plasma lipids. In addition, we will explore how the diabetic milieu (hyperinsulinemia and hyperglycemia) may alter the metabolism and normal activity of immune cells (macrophages) to accelerate atherosclerosis.

PI_NAMEs: GOEDEKE, LEIGH  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;Anti-diabetic Drugs;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Automobile Driving;Bioenergetics;Bioinformatics;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;career development;Cause of Death;Cells;Cholesterol;Chronic;controlled release;Data;Development;diabetic;diabetic patient;diet-induced obesity;Dyslipidemias;fat burning;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Fostering;gene therapy;Glucose;Glycolysis;Hepatic;High Fat Diet;hypercholesterolemia;Hyperglycemia;Hyperinsulinism;Hypertriglyceridemia;Immune;in vivo;Incidence;Individual;Inflammation;Inflammatory;insight;Insulin;Insulin Resistance;insulin sensitivity;Knowledge;large datasets;Learning;Link;Lipids;Liver;Liver Fibrosis;Liver Mitochondria;Macrophage;Measures;Mentors;Metabolic;metabolic profile;Metabolic syndrome;Metabolism;Methods;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;non-alcoholic fatty liver disease;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;nonhuman primate;novel;novel therapeutics;Obesity;Obesity Epidemic;Oral;oxidation;Phase;Plasma;Play;Postdoctoral Fellow;Predisposition;prevent;Prevention strategy;Publishing;Regulation;Relative Risks;Research;Research Personnel;responsible research conduct;Risk;Risk Factors;Rodent;Rodent Model;Role;Rupture;skills;stable isotope;Supervision;Therapeutic;Time;Tracer;Training;Triglycerides;Tumor-infiltrating immune cells;Uncoupling Agents;western diet;Work

PROJECT_TITLE: Cellular and molecular mechanisms of diabetic atherosclerosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This project will study nearly 2500 patients to better understand the factors and pathways leading to end stage kidney failure, cardiovascular disease, and premature death in individuals with diminished kidney function, using data collected both in clinic visits and home-based tests. Understanding the mechanism of progression of chronic kidney disease and its relationship to cardiovascular disease will advance the Objective 4-1 of Health People 2010 to improve the renal health of Americans.

PI_NAMEs: RAO, PANDURANGA S (contact)

PROJECT_TERMS: Adult;Affect;American;Ancillary Study;Arrhythmia;Biological;Cardiovascular Diseases;Cardiovascular Manifestation;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinic Visits;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Collection;Data Coordinating Center;data integration;Data Sources;design;Development;Disease Progression;Eligibility Determination;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Event;Evolution;follow-up;Funding;Future;Goals;Health;health data;Heterogeneity;Home;home test;improved;Individual;innovation;Institution;Investigation;Kidney;Kidney Diseases;Kidney Failure;Kidney Function Tests;Laboratory Research;Link;Measurement;Measures;Michigan;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational epidemiology;Outcome;Output;Parents;Participant;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phase;Phenotype;phenotypic data;Physiological;premature;Process;Productivity;programs;Prospective cohort;Prospective Studies;Prospective, cohort study;Protocols documentation;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Personnel;Resources;Risk Factors;Site;social;Source;tool;Translational Research;Universities;Visit

PROJECT_TITLE: Chronic Renal Insufficiency Cohort (CRIC) Study


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pregnancy;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Our proposal seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya. We will tailor a collaborative care model for peripartum women with HIV experiencing mental health symptoms and evaluate its impact on their mental health, antenatal, and HIV care outcomes. We will actively engage key stakeholders throughout the process and assess scalability and sustainability through multi-method approaches. This study will contribute to the overall goal of achieving optimal health outcomes for women living with HIV and their families in sub-Saharan Africa.

PI_NAMEs: ABUOGI, LISA LYNN (contact);ONONO, MARICIANAH ATIENO;TURAN, JANET M.

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Africa South of the Sahara;AIDS prevention;antenatal;antenatal care;antiretroviral therapy;Anxiety;anxiety symptoms;Behavioral;care burden;care outcomes;Caring;Case Manager;Chronic;Clinic;clinic ready;Clinical;collaborative care;common treatment;Communities;Complex;Comprehensive Health Care;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost effectiveness research;County;Data;Data Collection;design;dissemination research;Educational workshop;Effectiveness;effectiveness/implementation trial;efficacious intervention;efficacious treatment;Electronics;Ensure;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Failure;Family;Focus Groups;Goals;Government;Health;Health care facility;health goals;health service use;Health system;Healthcare;Healthcare Systems;HIV;HIV diagnosis;Hybrids;implementation barriers;implementation outcomes;implementation strategy;implementation study;improved;Income;Infant;informant;interdisciplinary approach;Intervention;Interview;intimate partner violence;Kenya;Lead;Link;low and middle-income countries;Maternal and Child Health;Maternal Health;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;model building;Modeling;Mothers;Outcome;Patients;peer coaching;Perinatal;Perinatal Care;perinatal mental health;Pharmaceutical Preparations;Policies;Policy Maker;postpartum care;postpartum health;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Outcome;Pregnant Women;Primary Care;Primary Health Care;Probability;problem solving therapy;Process;Protocols documentation;Provider;Psychiatric Nursing;Psychiatrist;Psychosocial Assessment and Care;Recovery;Request for Applications;Research;Resource-limited setting;Risk;scale up;Self Efficacy;Services;social determinants;Social Environment;social health determinants;social stigma;Specialist;support tools;Symptoms;System;Techniques;Testing;Training;Translating;United States National Institutes of Health;Viral;Viral Load result;Woman;women's outcomes;Work

PROJECT_TITLE: Integration of a collaborative care model for mental health services into HIV care for pregnant and postpartum women in Kenya (the Tunawiri Study)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Pediatric;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The research proposed in this application will advance the genetics of addiction by using innovative technology to provide experimental measurement of the consequences of thousands of genetics variants in regions of the human genome that code for proteins, as well as those regions that turn genes on and off. By contributing significantly to an understanding of the molecular contributions to addiction, this work will enable future development of treatments that directly target its underlying biological basis.

PI_NAMEs: BALDRIDGE, DUSTIN M (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Address;Agreement;autistic children;Biological;Biological Assay;career development;clinically relevant;Code;Collaborations;Dedications;Development;Disease;Doctor of Philosophy;exome sequencing;Fellowship;functional genomics;Funding;Future;Generations;Genes;Genetic;genetic variant;genome sequencing;genome wide association study;Genomic approach;Grant;Human;Human Genetics;Human Genome;Infrastructure;innovation;innovative technologies;Institution;Investments;Leadership;Link;Measurement;model organism;Molecular;multidisciplinary;mutation screening;Neurodevelopmental Disorder;neuropsychiatric disorder;Nucleic Acid Regulatory Sequences;Pathway interactions;Pediatrics;Phenotype;Postdoctoral Fellow;programs;Proteins;Qualifying;rare mendelian disorder;rational design;Reporter;Research;Research Personnel;Residencies;Sample Size;screening;substance use;Substance Use Disorder;Talents;Techniques;Testing;Therapeutic Intervention;therapy development;Thinking;Training;United States National Institutes of Health;Untranslated RNA;Variant;Work

PROJECT_TITLE: High-Throughput Functional Genomics of Variants in Genes Linked to Substance Use Disorders


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE  There is a compelling need to foster the development and research careers of clinician-scientist faculty at accredited academic institutions that graduate complementary and integrative health (CIH) professionals both to ensure high-fidelity innovative research on CIH and advance the science of CIH, but also to expose students to critical thinking and careers in research. The overarching goal of this application is to create a virtual resource center for REsearch Across Complementary and Integrative Health (REACH) clinical institutions to provide resources for collaborative research across clinician-scientist faculty located at these institutions. This REACH Center will take advantage of and build upon a successful effort begun in 2020 by Drs Herman and Coulter, called the RAND Center for Collaborative Research in CIH (RAND Center).

PI_NAMEs: COULTER, IAN DOUGLASS;HERMAN, PATRICIA M (contact);MAIERS, MICHELE

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Accreditation;Agreement;Applications Grants;Award;Biometry;Canada;career;Clinical;Clinical Informatics;Clinical Research;Clinical Sciences;Collaborations;Communities;Complementary Health;Complementary therapies;Computer software;Consultations;Critical Thinking;Data Set;Effectiveness;Ensure;Environment;Exposure to;Faculty;Fostering;Funding;Future;Goals;Grant;Health;Health Professional;health training;improved;Incubated;innovation;Institution;Integrative Medicine;Integrative Therapy;Interdisciplinary Study;Intervention;Knowledge;member;Mentors;multidisciplinary;Names;National Center for Complementary and Integrative Health;next generation;Online Systems;Outcome;outreach;Positioning Attribute;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Proposals;Research Training;Resource Sharing;Resources;satisfaction;Science;Scientist;Services;skills;Strategic Planning;Students;success;symptom management;symptomatic improvement;Training;user centered design;virtual;web platform;whole health

PROJECT_TITLE: RAND REACH Center


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The CRIC study was to established in 2003 to study chronic kidney disease (CKD) progression by identifying novel predictors of CKD progression and risk factors for cardiovascular disease among individuals with CKD. The CRIC Study recruited and followed a racially and ethnically diverse cohort of 5,625 participants and has defined trajectories of CKD progression, catalogued development, and evolution of comorbidities in CKD, and identified a diverse array of factors that explain the progression and complications of CKD in adults. The final phase of CRIC will focus on ascertaining clinical outcomes for all participants including those enrolled in the at home sub-protocols and integrate data from multiple domains to identify sub-phenotypes underlying the heterogeneity in CKD progression outcomes and create mechanisms for future data collection via linkages with external sources of health data to generate tools and resources to facilitate ongoing use of CRIC data and biospecimens by a broad group of investigators in the future.

PI_NAMEs: COHEN, DEBBIE L (contact)

PROJECT_TERMS: Adult;Affect;American;Ancillary Study;Arrhythmia;Biological;Cardiovascular Diseases;Cardiovascular Manifestation;cardiovascular risk factor;Cardiovascular system;care costs;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Collection;Data Coordinating Center;data integration;Data Sources;design;Development;disability;Disease;Disease Progression;disorder risk;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Evaluation;Event;Evolution;follow-up;Funding;Future;Goals;health data;Heterogeneity;Home;home test;Individual;innovation;Institution;Investigation;Kidney Diseases;Kidney Failure;Kidney Function Tests;Laboratory Research;Link;Measurement;Measures;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;novel;Observational epidemiology;Outcome;Output;Parents;Participant;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Pennsylvania;Phase;Phenotype;phenotypic data;Physiological;Premature Mortality;Process;Productivity;programs;progression risk;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Protocols documentation;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Personnel;Resources;response;Risk Factors;Site;social;Source;tool;Translational Research;Universities;Visit

PROJECT_TITLE: Prospective renal insufficiency cohort evaluation: PRICE


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative This study proposed to evaluate the effectiveness of repeated, systemic delivery of extracellular vesicles (EVs) in three doses secreted by Wharton’ Jelly derived mesenchymal stem cells (WJMSCs) in a murine myocardial infraction (MI) model. The optimal dose and regimen will be determined by evaluating the improvement in cardiac function and reduction in remodeling and proceed to the translation toward clinical effectiveness by evaluating in large animal (porcine) MI model. The study will also evaluate the molecular mechanism of EVs for cardiac repair and establishing characterization criteria to reduce donor-to-donor variability.

PI_NAMEs: HARE, JOSHUA M (contact);KHAN, AISHA

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: absorption;angiogenesis;Animal Model;Animals;Binding;Bioinformatics;Bioreactors;Brain imaging;burden of illness;Cardiac;Cardiac Myocytes;cardiac repair;Cardiovascular Diseases;Cells;Clinical;clinical application;Clinical effectiveness;Disease;dosage;Dose;Dyes;effectiveness evaluation;ex vivo imaging;exosome;extracellular vesicles;Family suidae;Fibroblasts;Future;Gender;Gene Expression;Goals;Heart;Heart failure;heart function;heart imaging;Heart Injuries;Histology;Homeostasis;Hour;Human;imaging system;improved;in vitro testing;in vivo bioluminescence imaging;Inflammation;Injections;innovation;intravenous administration;Label;large scale production;Liver;Long-Term Effects;Lung;manufacture;manufacturing process;Mediating;Membrane;Mesenchymal Stem Cells;Methods;Modeling;Molecular;mouse model;Mus;Muscle Cells;Myocardial;nanoparticle;Necrosis;Neonatal;novel;novel therapeutics;Operative Surgical Procedures;Organelles;Outcome;Outcome Study;particle;Patients;Pharmaceutical Preparations;Phenotype;PKH 26;Placebos;pre-clinical;Production;Qualifying;quantum;Rattus;reduce symptoms;Regimen;repaired;Reproducibility;Research Design;response;RNA;safety and feasibility;Site;sterility testing;Structure;Tail;Technology;Testing;Therapeutic Agents;Time;Tissues;transcriptome sequencing;Translating;Translations;treatment strategy;uptake;Variant;Veins;Ventricular;vesicular release;Western Blotting;Wharton's jelly

PROJECT_TITLE: Full-scale GMP Production for a Pre-Clinical Systemic Delivered Mesenchymal Stem Cells Derived Extracellular Vesicles For Cardiovascular Disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurodegenerative;Rare Diseases

ORG_CITY: SYRACUSE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Defects in mitochondrial and lysosomal functions are common hallmarks of aging and many aging- associated degenerative diseases, but whether and how these two organelles interact to affect cell fitness and disease development are poorly understood. We propose to investigate a novel mitochondria- to-lysosome proteostatic signaling pathway that causes vacuolar/lysosomal damage. The results may help us to better understand the mechanism of endolysosomal stress that is observed during aging and in aging-associated degenerative diseases.

PI_NAMEs: CHEN, XIN JIE  (contact);KANE, PATRICIA M

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Affect;Aging;aging related;aging related disease;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Atrophic;Autophagocytosis;biochemical tools;Biochemistry;Bioenergetics;Biological;Biology;Carrier Proteins;cell age;Cell Aging;Cell Death;Cell Death Induction;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;Child;Cytosol;Data;Defect;Degenerative Disorder;detection of nutrient;Development;Dilated Cardiomyopathy;Disease;Energy Metabolism;Environment;Enzymes;experimental study;Facioscapulohumeral Muscular Dystrophy;fitness;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;gene discovery;Genes;Genetic;genomic tools;Goals;hallmarks of aging;Homeostasis;Homologous Gene;Human;Impairment;in vivo;Ions;late endosome;Leigh Disease;life span;Lysosomes;Mammalian Cell;Mitochondria;Mitochondrial Diseases;Mitochondrial Proteins;Modeling;Molecular;mouse model;Multienzyme Complexes;Multivesicular Body;Mus;Muscular Atrophy;Mutation;NADH dehydrogenase (ubiquinone);Names;NAT2 gene;novel;Nuclear;Organelles;overexpression;Oxidative Phosphorylation;Parkinson Disease;Pathogenicity;Pathway interactions;Phenotype;Play;postmitotic;Process;Production;protein degradation;Protein Import;Proteins;Proton Pump;Rett Syndrome;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Stress;stressor;success;synergism;System;Testing;Tissues;trafficking;Transgenic Mice;vacuolar H+-ATPase;Vacuole;Yeasts;young adult

PROJECT_TITLE: A novel mitochondria-to-lysosome stress signaling pathway in degenerative disease and aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: HANOVER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE In this K01 Career Development Award, I will lead an in-depth study of risk factors associated with poor maternal and newborn health outcomes in a Medicaid population with disabilities in Texas to better understand the disparities faced by this population with respect to race and ethnicity, area-level socioeconomic conditions, and quality of healthcare. This study will include birthing people and their newborns across an urban-rural continuum and diverse socioeconomic environments with a comprehensive assessment of low birthweight, small for gestational age, preterm birth, neonatal mortality, and four quality of care indicators. The findings will add to our knowledge of adverse birth outcomes among racial and ethnic minorities with disabilities in the U.S. and inform targeted interventions and policies aimed at reducing the health inequities experienced by this population.

PI_NAMEs: DEV, ALKA  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: access disparities;Address;adverse birth outcomes;adverse outcome;Advocate;Affect;Age;Area;Award;Birth;Birth Certificates;Black Populations;black women;black/white disparity;career;career development;Cesarean section;Characteristics;Communities;comorbidity;cost;Coupled;Data;Data Files;data structure;Death Rate;delivery complications;deprivation;design;Development;Development Plans;Diagnosis;Disabilities experience;disability;disabled;Disabled Persons;Discipline of obstetrics;Disparity;Disparity population;Economic Conditions;Educational workshop;effective intervention;Enrollment;Environment;ethnic disparity;ethnic identity;ethnic minority;Ethnic Origin;experience;Faculty;Funding;Future;Goals;Health;health care quality;health disparity;health equity;Health Food;health inequalities;high risk;High-Risk Pregnancy;Hispanic Populations;Hospitalization;Hospitals;Household;Housing;improved;improved outcome;Income;Inequity;Infant;Infant Health;Infant Mortality;infant outcome;Institution;Insurance Coverage;Intellectual functioning disability;Intervention;K-Series Research Career Programs;Knowledge;Labor Complications;Lead;lens;Life;Link;Low Birth Weight Infant;Maternal Health;Maternal Mortality;Measurement;Measures;Medicaid;Mentorship;Methodology;Methods;mortality;Mothers;multilevel analysis;Musculoskeletal;Neighborhoods;neonatal health;Neonatal Intensive Care;Neonatal Mortality;Newborn Infant;Not Hispanic or Latino;obstetric outcomes;Outcome;outcome disparities;Persons;pilot test;Policies;Population;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnancy Rate;pregnant;Premature Birth;Prenatal care;Psyche structure;public health insurance;Quality of Care;Race;racial disparity;racial minority;Records;Research;Research Personnel;Research Project Grants;residential tenure;Risk;Risk Factors;Rural;rural area;rural residence;rurality;Series;Services;severe maternal morbidity;skills;Small for Gestational Age Infant;social;social determinants;socioeconomic disparity;socioeconomics;stillbirth;symposium;Testing;Texas;therapy design;Training;urban area;Urbanicity;Variant;Visit;Well Child Visits;White Women;Woman;Work

PROJECT_TITLE: Evaluating maternal and newborn health inequities at the intersection of race, ethnicity, and disability in the U.S


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Cardiovascular disease is the leading cause of death worldwide and new therapies are needed to treat this very prevalent disease. We have identified a protein called STK25 that is able to downregulate one of the central signaling pathways that controls how strong the heart is able to contract. We propose to study how this protein is able to regulate cardiac function and whether this new relationship has therapeutic potential in heart failure.

PI_NAMEs: FINE, BARRY M. (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: A kinase anchoring protein;Adrenergic Agents;Affinity;Animal Model;Anterior;Arteries;Binding;Biochemical;Biological Models;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Catalytic Domain;Catecholamines;Cause of Death;Cell Death;Cell Line;Cell Survival;Chronic;Complex;conditional knockout;Contracts;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Disease;drug development;Dryness;Echocardiography;experimental study;Fibrosis;fighting;follow-up;Gene Modified;Heart;Heart failure;heart function;Histologic;Human;Human Cell Line;human induced pluripotent stem cells;improved;improved outcome;In Vitro;in vitro activity;in vivo;Incidence;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inhibitor;insight;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Lead;Left;Ligation;Loss of Heterozygosity;Macromolecular Complexes;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Mediating;Medical;Metabolic;Metabolism;mimetics;Modality;Modeling;mortality;mouse model;Mus;Mutation;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;Outcome;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physiology;pressure;Prevalence;prevent;Proliferating;Protein Dephosphorylation;Protein Inhibition;protein kinase A kinase;Protein Phosphorylation Inhibition;Protein Subunits;Proteins;Proteomics;Publishing;recruit;Regulation;release of sequestered calcium ion into cytoplasm;Renin-Angiotensin-Aldosterone System;response;Role;Second Messenger Systems;Serum Markers;Signal Pathway;Signal Transduction;Specificity;Surveys;Survival Rate;System;Testing;Therapeutic;therapeutic target;Time;Transgenic Mice;translational potential;Work

PROJECT_TITLE: STK25 phosphorylates PRKAR1A to regulate PKA signaling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Early recognition of cognitive impairment and timeliness in Alzheimer's Disease and Related Dementias (ADRD) diagnoses are key to optimal dementia care. To the best of our knowledge, no studies have examined the effect of the annual wellness visit (AWV) policy on reducing disparities in ADRD diagnosis and health outcomes among community-dwelling Medicare beneficiaries with ADRD, based on the Institute for Healthcare Improvement (IHI) 4Ms framework of an age-friendly health system, 4Ms: "what matters," "mentation," "mobility," and "medication." This 5-year project will adopt IHI's 4Ms framework, as recommended by the Alzheimer's Association, in conducting a convergent parallel mixed-methods study to address this gap to inform AWV policy and practice guideline development to improve the timeliness of ADRD diagnosis and post- ADRD-diagnosis dementia care, thereby decreasing health disparities among Medicare beneficiaries with ADRD.

PI_NAMEs: KUO, YONG-FANG ;RAJI, MUKAILA A;TZENG, HUEY-MING  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: acute care;Address;Adopted;Adoption;Advance Care Planning;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attention;beneficiary;Black American;black men;black women;Caring;Cognition;Communities;community partners;Consultations;cost;Credentialing;Data;Data Analyses;Data Collection;Data Linkages;Data Scientist;Dementia;dementia care;Development;Diagnosis;Disadvantaged;Disparity;disparity reduction;Ensure;ethnic difference;Ethnic Origin;Ethnic Population;Evaluation;Exposure to;Fall prevention;fall risk;falls;Family Caregiver;family caregiving;Family Practice;Fracture;Friends;Health;health care quality;health care service;health disparity;Health Policy;Health Services;Health system;Healthcare;High Prevalence;high risk;Hispanic;Hispanic Americans;Hispanic Women;Impaired cognition;improved;Independent Living;individualized prevention;interest;Internal Medicine;International;Internist;Interview;Link;Medicare;men;Mental Depression;Methods;Nurse Practitioners;Nurses;older adult;Outcome;outcome disparities;Patients;Persons;Pharmaceutical Preparations;Physical environment;Physicians;Policies;Practice Guidelines;prevent;Preventive service;Primary Care;Race;racial difference;racial population;Random Allocation;Recommendation;Reduce health disparities;Rehabilitation therapy;Research Design;Research Personnel;research study;Retirement;Risk Assessment;Rural;Sampling;Scientist;Self Care;sex;Sex Differences;Social Work;Socioeconomic Status;socioeconomics;sound;Surveys;Telephone;Texas;trend;United States Centers for Medicare and Medicaid Services;urban residence;wellness visit;White Women;Woman;Work

PROJECT_TITLE: Annual wellness visit policy: Impact on disparities in early dementia diagnosis and quality of healthcare for Medicare beneficiaries with Alzheimer's Disease and Its Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Cerebrovascular dysfunction, which severely impacts brain health, is an early pathological feature of Alzheimer’s Disease (AD) and Cerebral Amyloid Angiopathy (CAA) brains. The mechanisms that link cerebrovascular dysfunction to AD and CAA widespread pathology are not known. The proposed study will help in understanding how endothelial cell mitochondria mediate cerebrovascular dysfunction and how mitochondria-mediated endothelial activation signaling pathways contribute to neuroinflammation, precipitating AD and CAA pathology.

PI_NAMEs: PARODI-RULLAN, REBECCA MARIA (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Acceleration;Affect;Age;Age Months;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloidosis;Animal Model;Animals;Astrocytes;Behavioral;Biochemical;Bioenergetics;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;brain endothelial cell;brain health;Cell Culture Techniques;Cell Death;cell injury;Cells;Cerebral Amyloid Angiopathy;cerebral microbleeds;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;cognitive function;Communication;CRISPR/Cas technology;cyclophilin D;Data;Deposition;Development;Disease;Disease Progression;effective therapy;Endothelial Cells;Endothelium;Event;experimental study;extracellular;Failure;Functional disorder;Gatekeeping;Genes;Gliosis;Health;Hemorrhage;Homeostasis;Human;human induced pluripotent stem cells;hyperphosphorylated tau;Immunofluorescence Immunologic;Impaired cognition;in vitro testing;in vivo;in vivo evaluation;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Link;LoxP-flanked allele;Maintenance;Mediating;Mediator;Microglia;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial permeability transition pore;Mitochondrial Swelling;Molecular;Movement;Mus;Nerve Degeneration;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;neurovascular;neurovascular unit;non-demented;novel;novel therapeutic intervention;Oral Administration;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Pericytes;Permeability;prevent;Production;Reactive Oxygen Species;Research;Role;Rupture;Senile Plaques;sensor;Signal Pathway;Superoxides;tau Proteins;Testing;Therapeutic;tool;Variant;Vascular Diseases;Vascular Endothelium;vascular inflammation

PROJECT_TITLE: Cerebrovascular mitochondria as mediators of neuroinflammation in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: REELIN THERAPEUTICS, INC.

PHR: Project Narrative Chronic inflammation contributes in a substantial way to the pathology observed in multiple chronic degenera- tive diseases, including Down’s syndrome (DS). In this application, we explore the feasibility of targeting a novel pro-inflammatory system, based on the interaction of Reelin with Apolipoprotein-ER2, to decrease disease progression in a mouse model of human DS. 1

PI_NAMEs: CALVIER, LAURENT ;HERZ, JOACHIM J;KOUNNAS, MARIA Z (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Adhesions;Affinity;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein Precursor;Amyotrophic Lateral Sclerosis;Antibodies;apolipoprotein E receptor 2;Apolipoproteins;Astrocytes;Binding;Biological;Blood Vessels;Brain;Cell Adhesion Molecules;Cell Physiology;cell type;Cells;Chromosome 21;Chronic;Copy Number Polymorphism;DAB2 gene;Data;Degenerative Disorder;Dementia;Disease;Disease Progression;Down's Syndrome;E-Selectin;Early Onset Alzheimer Disease;Effectiveness;Endothelial Cells;Etiology;Extracellular Matrix Proteins;Extravasation;Foundations;Future;Grant;Histologic;Human;human model;Immune;Immunologic Receptors;Individual;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Intercellular adhesion molecule 1;Intervention;Invaded;Lead;Leukocyte Adhesion Molecules;Leukocytes;Mediating;Methods;Microglia;Modeling;Monoclonal Antibodies;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;Neurons;new therapeutic target;novel;overexpression;Parkinson Disease;Pathology;Pathway interactions;Patients;Plasma;Plasma Proteins;preclinical development;Preclinical Testing;prevent;Process;Proteins;receptor;recruit;response;Risk Factors;Role;Senile Plaques;Site;Source;System;Testing;Therapeutic;therapeutic development;Tissues;Trisomy;Vascular Cell Adhesion Molecule-1;Vascular Endothelium

PROJECT_TITLE: Effect of APP copy number variants in Alzheimer's disease and and Down Syndrome on Reelin expression and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)]


ORG_CITY: BASEL

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: UNIVERSITY OF BASEL

PHR: PROJECT NARRATIVE: It is expected that novel pathways and neuro-immune mechanisms uncovered by this research will have far reaching consequences in terms of how neurons regulate immune responses in inflammation and cancer, thus enhancing our understanding of the immune system in health and disease.

PI_NAMEs: DIXON, KAREN OLIVIA (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Ablation;Affect;Afferent Neurons;anti-cancer research;anti-tumor immune response;Antigen Presentation;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;cancer cell;cancer therapy;CD8-Positive T-Lymphocytes;Cells;Clinical;Colon Adenocarcinoma;Colorectal Cancer;Communication;Cross Presentation;cytokine;Data;Dendritic Cells;density;design;Disease;draining lymph node;Experimental Models;Fostering;Functional disorder;Funding;Gene Expression;Genetic Transcription;Growth;Health;Immune;Immune response;Immune system;immunoregulation;Immunotherapy;Inflammation;Infrastructure;Interdisciplinary Study;Knowledge;Lung Neoplasms;Malignant Neoplasms;malignant stomach neoplasm;Modeling;multiplexed imaging;Neoplasm Metastasis;Nerve;nerve supply;Nervous System;Neurogenic Inflammation;Neuroimmune;Neuroimmunomodulation;Neuromodulator;Neurons;Neuropeptide Receptor;Neuropeptides;Neurosciences;Neurosciences Research;Nociceptors;Normal tissue morphology;novel;novel therapeutic intervention;Organ;Pancreas;Pathogenesis;Pathway interactions;Patients;Peripheral;Physiological;Physiology;Play;Population;Pre-Clinical Model;Prevention;Process;Prostate;receptor;recruit;Reporter;Reporting;Research;response;Role;Sampling;Sensory;Sensory Receptors;Shapes;Skin Neoplasms;Stimulus;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;Translating;treatment response;TRPV1 gene;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor immunology;tumor initiation;Tumor Markers;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Dissecting Neuro-Immune Interactions in Cancer


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative For organisms to reproduce, their genomic DNA must be copied faithfully. This process, DNA replication, requires frequent repair events to ensure that it occurs efficiently and without error. We seek to identify and understand factors in microorganisms that facilitate repair of blocked replication in order to understand similar processes in humans that prevent cancer, aging and genetic disease.

PI_NAMEs: LOVETT, SUSAN THOMAS (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Aging;Antibiotic Resistance;Bacteria;Bacteria sigma factor KatF protein;Base Pairing;Binding;Binding Proteins;Biochemical;Cell Survival;Cells;Closure by clamp;cold shock protein;Complex;conflict resolution;Copying Processes;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA metabolism;DNA Polymerase III;DNA Repair;DNA replication fork;DNA-Directed RNA Polymerase;Electron Transport Complex III;Escherichia coli;Event;Evolution;Genes;Genetic;genetic analysis;genetic approach;Genetic Diseases;Genetic Materials;Genetic Transcription;Genome;Genome Stability;Genomic DNA;Genomic Instability;Goals;Gram-Negative Bacteria;Growth;Head;helicase;Holoenzymes;Human;Immunologics;Infection;infectious disease treatment;Information Protection;inhibitor;interest;Interruption;Left;Malignant Neoplasms;Mediating;microbial;microorganism;Microscopic;model organism;Molecular Biology;mutant;Mutation;Neurologic;novel;Nucleotides;Organism;pathogenic bacteria;pathogenic microbe;Pathway interactions;Physiology;Play;Premature aging syndrome;prevent;Process;Production;Proliferating;Property;Protein Biochemistry;protein complex;Proteins;Reaction;recruit;Regulatory Pathway;repaired;response;rho;Ribosomal RNA;RNA;Role;rRNA Operon;Signal Transduction;Site;Starvation;Structure;System;Testing;Toxin;Transcript;Transcription Coactivator;transcription termination;Transcriptional Regulation;Virulence Factors;Visualization;Work

PROJECT_TITLE: Replication Fork Repair

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Lymphatic Research;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Durable antitumor immunity requires presentation of tumor antigens by professional antigen presenting cells (APCs) for priming of antitumor T cell responses, but APC function is repressed in the immunosuppressive tumor microenvironment. This project will decipher the mechanisms of the unique immune stimulation provided by recombinant poliovirus, resulting from non-lethal infection and pro-inflammatory activation of APCs. The significance of this research is the potential to achieve significant clinical benefits for cancer patients by reinstating tumor immune surveillance.

PI_NAMEs: GROMEIER, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adoptive Transfer;Antigen-Presenting Cells;Antigens;antitumor effect;Attenuated;Autopsy;Brain;Brunhilde Virus;cancer immunotherapy;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cells;Cervical lymph node group;Chemotaxis;Clinical;Clinical Trials;Cross Presentation;Cytoplasm;cytotoxic;Dendritic cell activation;Dendritic Cells;Disease;Double-Stranded RNA;Engineering;Focal Infection;gastrointestinal;Glioblastoma;Glioma;glymphatic system;Human;Human poliovirus;IFIH1;Immune;immune checkpoint blockade;Immunity;Immunologic Stimulation;Immunologic Surveillance;Immunology;Immunotherapy;imprint;In Vitro;in vivo;Infection;Infiltration;Inflammatory;Injections;insight;Interferon Type I;Interferons;Internal Ribosome Entry Site;Investigation;ITGAM gene;ITGAX gene;lymph nodes;Lymphatic System;lymphoid structures;Lymphoid Tissue;Macaca;Macrophage;Malignant Neoplasms;Mediating;Melanoma;migration;Modeling;Mononuclear;Mus;Myelogenous;Myeloid Cells;Natural Killer Cells;Necrosis;Nodal;Non-Malignant;Normal Cell;Oral;Outcome;Pan Genus;pathogen;Pathogenicity;patient subsets;Patients;Pattern;Pattern recognition receptor;Peripheral;Phagocytes;radiological imaging;Reaction;Receptor Signaling;Recombinants;recruit;Recurrence;Reporting;Repression;Research;Resistance;Resolution;response;Rhinovirus;RNA Viruses;Role;safety study;Schedule;sensor;Signal Transduction;Site;Slice;spatiotemporal;Spleen;Stimulus;T cell response;T-Lymphocyte;TAP1 gene;Testing;trafficking;translational study;Tropism;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Vaccines;Viral;Virulence;Virus;Widespread Disease

PROJECT_TITLE: Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric;Physical Activity;Prevention

PHR: PROJECT NARRATIVE Spending time outdoors increases children’s physical activity and improves mental, cognitive and behavioral health outcomes, but measurement of outdoor time is varied and often self- or caregiver-reported. The proposed research will capitalize on existing data from several trials to develop a set of analytic guidelines for using accelerometer measured ambient light sensor data as an objective measure of children’s outdoor time. With the ubiquitous use of accelerometers in research, these guidelines can be applied to further understand the relationship between health and the outdoors, identify disparities in access to outdoor settings, and inform policies and regulations to promote physical activity and outdoor time.

PI_NAMEs: NESHTERUK, CODY  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;access disparities;Accounting;Affect;behavioral health;Caregivers;Child;Child Care;child day care;Cognitive;Data;Data Analyses;data repository;Data Set;Databases;Disparity;Environment;Exposure to;Funding;Guidelines;Health;Health Benefit;Hip region structure;improved;Individual;Intervention;Intervention Trial;Kentucky;Light;Link;Measurement;Measures;meteorological data;Methods;National Heart, Lung, and Blood Institute;Nature;open source;Outcome;Physical activity;Policies;Preschool Child;Psyche structure;Receiver Operating Characteristics;Regulation;Reporting;Research;Research Activity;Research Personnel;ROC Curve;Seasons;sensor;sensor technology;Source Code;Sunlight;Testing;Time;time use;tool;Validation;Visual;Weather;Wrist;wrist worn device;Youth

PROJECT_TITLE: Establishing best practices for the use of accelerometer measured ambient light sensor data to assess children's outdoor time


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The lack of comprehensive metrics to determine the maturation status of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) remains a key obstacle to assess the effects of ongoing efforts to mature PSC-CMs. We have developed a novel entropy-based metric that enables quantitative assessment of PSC-CM maturation, and this proposal focuses on using this metric to directly compare PSC-CMs matured by new and existing strategies with native CMs undergoing maturation. This will provide quantitative and mechanistic insights into generating mature adult CMs from PSCs.

PI_NAMEs: KIM, DEOK-HO ;KWON, CHULAN  (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Algorithms;Animals;Benchmarking;Biological;Cardiac Myocytes;cardiac tissue engineering;Cells;Clinical Trials;Data;Data Set;Development;Electric Stimulation;Engineering;Entropy;fetal;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Generations;Genes;Genetic Transcription;Glucocorticoid Receptor;Goals;Heart;heart damage;human tissue;in vivo;Incubated;Infarction;insight;Libraries;mature animal;Measures;Mechanical Stimulation;Meta-Analysis;Metabolic;Methodology;Methods;Modeling;Molecular;multiple datasets;Mus;novel;Output;particle;Perinatal;Peroxisome Proliferator-Activated Receptors;Pluripotent Stem Cells;postnatal;Preparation;Protocols documentation;receptor;repaired;Research;single-cell RNA sequencing;Sorting;species difference;Structure;Testing;Thyroid Hormone Receptor;Time;Tissue Engineering;Tissue-Specific Gene Expression;Tissues;tool;transcriptome;transcriptomics;Transplantation

PROJECT_TITLE: Transcriptomic Entropy to Quantify Maturation of PSC-Derived Cardiomyocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Enterovirus D68 (EV-D68) is a viral pathogen that causes moderate to severe respiratory illness in children and immunocompromised person, and in rare cases also leads neurological complications such as polio-like acute flaccid myelitis (AFM) as well as death. Currently there are no approved antiviral drugs or vaccines for the diseases associated with EV-D68 infection. To address the unmet medical need, we will develop potent and selective EV-D68 2Apro inhibitors with favorable pharmacokinetic properties and use them as chemical probes to validate EV-D68 2Apro as a viable antiviral drug target in both in vitro cell cultures and in vivo mouse model studies.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Active Sites;acute flaccid myelitis;Address;analog;Anti-viral Agents;anti-viral efficacy;Biological Assay;burden of illness;Caspase;Cell Culture Techniques;Cells;Cellular Assay;Cessation of life;Chemicals;Child;clinically relevant;design;Disease;Disease Outbreaks;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Targeting;Early treatment;Enterovirus 68;experimental study;FDA approved;Fluorescence Resonance Energy Transfer;future outbreak;Goals;Hepatitis C virus;Human;Human Cell Line;Immunocompromised Host;In Vitro;in vivo;in vivo evaluation;Infection;inhibitor;Intraperitoneal Injections;Lead;lead optimization;Libraries;Manuscripts;Medical;meter;Methodology;mouse model;Mus;Mutation;National Institute of Allergy and Infectious Disease;neonatal mice;Nervous System;Neurologic;Neurons;novel;Oral;Outcome;Paralysed;pathogenic virus;Pattern;pediatric patients;Peptide Hydrolases;Permeability;Persons;Pharmaceutical Preparations;Poliomyelitis;Polyproteins;Preparation;priority pathogen;Property;Protease Inhibitor;Proteins;Publishing;Reporting;Research;Resolution;respiratory;Respiratory Disease;Roentgen Rays;Route;Sequence Homology;Serine Protease;Solubility;Structure;Structure-Activity Relationship;Study models;Testing;Tissues;tool;United States;vaccine access;Vaccines;Validation;Viral;Viral Load result;Viral Physiology;Viral Proteins;Virus;Virus Replication;Work

PROJECT_TITLE: Drug target validation of the enterovirus D68 2A protease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This training program in Chemistry-Biology Interface at UC San Diego is designed expressly for the training of graduate students, the nation’s future scientific leaders, in the practice of chemical biology. The students will be instructed and mentored in this vibrant interdisciplinary field that contributes to the fundamental knowledge about living systems and applies that knowledge to enhance health, lengthen life, and reduce illness and disability. The student training benefits from direct mentorship of a select faculty group, including research theory, methods, practice, ethics, and camaraderie.

PI_NAMEs: BURKART, MICHAEL D. (contact);KOMOR, ALEXIS C.

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemistry

PROJECT_TITLE: Chemistry-Biology Interfaces at UCSD

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Data Science;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE IBD is a model, complex trait for which genetic factors play a substantial role. Major effect loci show major differences in allele frequencies and effect sizes across populations, for which expanding case-control genetic data will provide substantial mechanistic insight. Treatments for Crohn’s disease and ulcerative colitis are increasingly diverging, and multi-omic data integration, with serial tissue and blood-based biosampling in clinical scenarios of unmet clinical needs, will broadly advance Precision IBD.

PI_NAMEs: CHO, JUDY H. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acceleration;Acute;Affect;African;African American;Alleles;Anal Fistula;Anus;Biological;Blood;case control;Categories;cell type;Cells;Chronic;Clinical;clinical care;cohort;Communication;Communities;Complex;Crohn's disease;Data;Data Analyses;Data Collection;Data Commons;Data Coordinating Center;data integration;Data Set;database of Genotypes and Phenotypes;Development;Disease;Ensure;epithelial stem cell;Excision;exome;Flare;Functional disorder;Gene Expression;Gene Frequency;gene function;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Research;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;Hispanic;Hospitalization;improved;Individual;Industry;Inflammation;Inflammatory Bowel Diseases;Infrastructure;insight;International;Investments;Latinx;Linkage Disequilibrium;longitudinal analysis;Lymphocyte;Maps;Medical;microbial;Mission;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;Multiomic Data;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Outcome;Patients;peripheral blood;Phenotype;Pilot Projects;Play;Population;Population Heterogeneity;Prevalence;protein biomarkers;rare variant;recruit;Recurrent disease;repository;Research;Research Design;Resolution;Resources;response;Role;Sampling;Services;Signal Transduction;Social Justice;Standardization;stem cells;Technology;Therapeutic;Tissues;trait;transcriptome;transcriptomics;U-Series Cooperative Agreements;Ulcerative Colitis;Variant;web site;whole genome;XCL1 gene

PROJECT_TITLE: Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Mutations affecting enzymes involved in epigenetic regulation are frequently identified in human developmental disorders and cancers, but how they facilitate disease pathogenesis remains poorly understood. This project proposes to invent and apply novel molecular and genetic tools to investigate the regulation and function of a conserved chromatin modification – methylation of histone H3 lysine 36 (H3K36). Our studies are expected to establish the conceptual framework required for developing therapeutic strategies against diseases driven by abnormal H3K36 methylation.

PI_NAMEs: LU, CHAO  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;antagonist;ASH1L gene;Biochemistry;Biology;bone;Chemicals;Chromatin;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;developmental disease;Disease;DNA Methylation;DNA Modification Methylases;DNA Modification Process;DNMT3a;Enzymes;epigenetic regulation;epigenome editing;Family member;Genetic;Genetic Screening;Genome;genome editing;Genomics;Germ-Line Mutation;Goals;Head and Neck Cancer;Histone H3;histone methylation;Histones;Human;Human Development;human disease;innovation;insight;Intercistronic Region;interest;Intergenic DNA;Introns;invention;Kinetics;knowledge base;Lead;Lysine;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;Molecular;Mutation;Neoplastic Cell Transformation;Neurodevelopmental Disorder;novel;Pathogenesis;programs;recruit;Recurrence;Regulation;Regulatory Element;Repetitive Sequence;Research;Resources;System;Therapeutic;tool;transcription factor;Work;Yeasts

PROJECT_TITLE: Regulation and Function of Histone H3K36 Methylation in Mammalian Chromatin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative. Schizophrenia (SCZ) has a tremendous economic and societal impact, which could be mitigated by the discovery of novel treatment interventions targeting specific neuronal circuit dysfunction, especially early in the illness. The overarching goal of this proposal is to establish whether, by acutely enhancing prefrontal oscillatory activity, we see a corresponding improvement in working memory (WM) function in early course SCZ patients. Building on these findings, future neuromodulation-based treatment interventions applying chronic doses of TBS may more persistently ameliorate/restore DLPFC oscillatory parameters and related WM impairments in SCZ patients early during the illness, thus significantly improving their cognitive functioning and overall quality of life.

PI_NAMEs: FERRARELLI, FABIO  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acute;Affect;Assessment tool;Attention;Biological Markers;Brain;Chronic;Chronic Schizophrenia;cognitive benefits;cognitive function;Conscious;design;Disease;Dose;Economic Burden;Economics;Electroencephalography;Electrophysiology (science);follow-up;Frequencies;Functional disorder;Future;Goals;Impaired cognition;Impairment;improved;Individual;Intervention;Measures;Memory;Memory impairment;Motivation;neural;neural circuit;neural network;neuroimaging;neuronal circuitry;Neurons;neuroregulation;noninvasive brain stimulation;novel;Patients;Pattern;Performance;Physiologic pulse;Prefrontal Cortex;Quality of life;Reporting;Role;Schizophrenia;severe mental illness;Short-Term Memory;Transcranial magnetic stimulation;verbal;Work

PROJECT_TITLE: Enhancing prefrontal oscillatory activity and working memory performance with noninvasive brain stimulation in early-course schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE Biochemistry does not occur in a vacuum. Several molecules, ions, and biomolecules gather to create an optimal biochemical environment required for any biochemical process to occur. In this proposed research, we will investigate the impact of such a biochemical environment on the metal "breathing" machinery of marine bacteria and photoinduced allosteric processes with potential applications in bioremediation and optogenetics technologies.

PI_NAMEs: ACHARYA, ATANU  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: Investigation of Long-Range Charge Transfer and Excited State Processes in Biochemical Systems


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Precision Medicine;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Aortic stenosis ultimately leads to heart failure and death, but valve replacement is curative. For many patients, valve replacement is performed too late, after damage to the heart muscle is no longer reversible, resulting in persistent symptoms and increased risk for death. The goal of my research is to identify compounds within the blood that can serve as an early warning that the heart is struggling to overcome aortic stenosis and can therefore help physicians plan the optimal timing of valve replacement surgery.

PI_NAMEs: ELMARIAH, SAMMY  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Adopted;Affect;aortic valve replacement;Aortic Valve Stenosis;Biological Process;Blood;Cardiac;Cause of Death;Cessation of life;classification algorithm;Clinical;Clinical Practice Guideline;clinical predictors;cohort;comorbidity;Complex;Data;Death Rate;Development;Disease;Distress;Early Intervention;Echocardiography;Elderly;Energy Metabolism;experience;Functional disorder;Goals;Grant;Growth;Health;Health Status;Heart;heart dimension/size;Heart failure;heart function;Heart Injuries;Heart Valve Diseases;Impairment;improved;Individual;Injury;Intervention;Left;Left Ventricular Ejection Fraction;Left Ventricular Remodeling;machine learning classification;Measures;Metabolic;metabolomics;Modeling;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;multiple omics;Myocardial dysfunction;Myocardium;Operative Surgical Procedures;Outcome;patient registry;Patients;persistent symptom;Physicians;precision medicine;predict clinical outcome;predicting response;predictive signature;pressure;Prospective cohort;Proteins;proteomic signature;Proteomics;Public Health;Qualifying;Recommendation;Research;response;Risk;Sampling;Science;Structure;Symptoms;Systems Biology;Testing;Time;valve replacement;Ventricular;Work

PROJECT_TITLE: Multi-omic markers of cardiac function and structure within the pressure overloaded heart

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Patient Safety;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The proposed research is relevant to the public health because primary and metastatic central nervous system (CNS) tumors are associated with high morbidity and mortality; and few effective therapies are currently available. Upon conclusion of the study, we will have developed and validated a CSF liquid biopsy assay for early molecular characterization and monitoring of primary or metastatic tumors affecting the CNS. This will facilitate the incorporation of precision medicine strategies in the management of adult and pediatric patients with primary or metastatic CNS tumors, and avoid the need for brain surgery in some patients.

PI_NAMEs: BALLESTER, LEOMAR Y (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adult;Affect;assay development;Biological Assay;Biological Markers;Biopsy;Blood;Brain Neoplasms;brain parenchyma;brain surgery;cancer cell;cancer type;Central Nervous System Neoplasms;Cerebrospinal Fluid;Clinical;clinical implementation;clinical practice;Collection;Data;Detection;Development;Diagnosis;digital;effective therapy;experimental study;Gene Frequency;Genes;Glioma;innovation;Lesion;liquid biopsy;Liquid substance;Magnetic Resonance Imaging;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;mutant;Mutate;Mutation;Mutation Detection;Neoplasm Metastasis;Neoplasms;next generation sequencing;novel;novel strategies;Nucleic Acids;Oncogenic;Patient Monitoring;Patients;pediatric patients;precision medicine;Primary Neoplasm;Production;Public Health;Recurrent tumor;repository;Research;Sampling;Sensitivity and Specificity;Source;targeted treatment;Tissue Sample;Tissues;treatment response;tumor;Tumor Burden;tumor DNA;Tumor Tissue;Tumor Volume;Tumor-Derived;Validation

PROJECT_TITLE: Development and Validation of a CSF Liquid Biopsy for Molecular Characterization and Monitoring of Patients with Central Nervous System Tumors

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Lung;Precision Medicine;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Sleep disordered breathing (SDB) is a heritable common disorder associated with adverse cardiometabolic outcomes, and the underlying molecular mechanisms are poorly understood. We will develop a novel pathway-level transcriptional Mendelian randomization approach to identify causal molecular associations for SDB. This study will improve our understanding of the underlying biological background of SDB and inform novel biomarker and/or treatment target for SDB.

PI_NAMEs: WANG, HEMING  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;Affect;Apnea;biobank;Biochemical;Biological;Biological Markers;Biological Process;Biology;Blood Cells;Body mass index;Breathing;Candidate Disease Gene;Cardiometabolic Disease;cardiometabolism;case control;Clinical;Complex;Computing Methodologies;Data;data resource;Databases;design;Disease;Disease Outcome;Ethnic Origin;Etiology;Excessive Daytime Sleepiness;Framingham Heart Study;Gene Expression;Genes;Genetic;genetic association;Genetic Determinism;Genetic Transcription;genome wide association study;genomic data;Genomics;Genotype;heme biosynthesis;Heritability;Heterogeneity;Hypoxemia;improved;indexing;Individual;Inflammatory;instrument;Knowledge;Mendelian randomization;Meta-Analysis;metabolomics;Methods;Modeling;Molecular;mortality;Multi-Ethnic Study of Atherosclerosis;multiple omics;National Heart, Lung, and Blood Institute;novel;novel marker;novel strategies;Obesity;Older Population;Ontology;Outcome;Pathway interactions;Phenotype;Physiological;Population Study;Process;Proteomics;Publishing;Quantitative Trait Loci;Race;Records;Recurrence;Research;Risk;Sample Size;Sampling;secondary analysis;Severities;sex;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;Snoring;statistics;System;Testing;Tissues;trait;Trans-Omics for Precision Medicine;Transcript;transcriptome;transcriptomics;whole genome;Women's Health

PROJECT_TITLE: Pathway-level transcriptional causal mechanism of sleep disordered breathing

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Neurodegenerative;Palliative Care;Rehabilitation

PHR: Project Narrative Dementia affects nearly 5 million Americans, and is projected to affect 14 million by 2050. It causes significant suffering for patients and those caregivers who care for them at home. Our home-based palliative care intervention will improve patient symptoms; reduce caregiver burden; and decrease healthcare utilization.

PI_NAMEs: GOLDSTEIN, NATHAN E;MORRISON, R. SEAN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Academy;Activities of Daily Living;acute care;Address;advanced dementia;Advanced Practice Nurse;Affect;Algorithms;Alzheimer's disease related dementia;American;care costs;Caregiver Burden;caregiver depression;caregiver interventions;Caregiver support;Caregivers;Caring;Case Management;Chronic Disease;Communication;Communities;Community Health Aides;comparison control;Complex;Control Groups;cost;Country;Dementia;dementia care;Dementia caregivers;depressive symptoms;effectiveness evaluation;Elements;Eligibility Determination;end of life;end of life care;Enrollment;Environment;Equipment and supply inventories;experience;Family;Family Caregiver;Functional impairment;functional status;global deterioration scale;Goals;group intervention;health care service utilization;Health system;Healthcare;Healthcare Systems;Home;hospice environment;Hospitalization;Hospitals;Impaired cognition;Improve Access;improved;Individual;innovation;Inpatients;Intervention;Long-Term Care;loved ones;Measures;Medical;medical specialties;Medicine;Mental Depression;Modeling;New York City;novel;Nurses;older adult;Outpatients;Palliative Care;Patient Care;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physicians;Positioning Attribute;preference;prevent;Prognosis;programs;Provider;psychosocial;Quality of life;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Registered nurse;Resources;satisfaction;Self Care;Services;Single-Blind Study;Site;Social Workers;Stress;Structure;symptom management;symptomatic improvement;Symptoms;Telephone;Time;Training;Underserved Population;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Palliative Care at Home for Patients with Dementia

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: Project Narrative  Bacterial pathogens pose a serious threat to human health. Developing drugs to treat infections caused by pathogens that grow inside host cells is particularly challenging as this environment protects them from exposure to many antibiotics. The goal of this research is to define critical strategies employed by these pathogens to establish growth as a means to identify novel targets for therapeutic intervention.

PI_NAMEs: O'CONNOR, TAMARA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Aerosols;Affect;Alveolar Macrophages;anti-microbial drug;Antibiotics;Architecture;Area;Bacteria;Binding;Biochemistry and Cellular Biology;Biogenesis;Biology;biophysical properties;Cell Death;Cell Physiology;Cells;Communicable Diseases;contaminated water;Dependence;Detection;detection platform;Development;Disease;Electron Microscopy;emerging antibiotic resistance;Environment;exposed human population;Exposure to;fatty acid metabolism;Fatty Acids;Fluorescence Microscopy;Genes;Genetic;Goals;Growth;Health;Homeostasis;Hospitalization;Human;Immune;Immune system;Impairment;Infection;Inhalation;Knowledge;Legionella;Legionella pneumophila;Legionellosis;Life;Link;lipid metabolism;Lipids;Lung;Maintenance;man;Membrane;Membrane Proteins;Metabolic;Molecular Biology Techniques;new therapeutic target;novel therapeutics;Nutrient;Organelles;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;peroxisome;Pharmaceutical Preparations;Play;Pneumonia;prevent;Process;Production;programs;Proteins;recruit;Recycling;Research;Role;Source;System;Therapeutic Intervention;United States;Vacuole;Virulence;Water;Work

PROJECT_TITLE: Deciphering the role of peroxisomes in bacterial pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Cells with activated proto-oncogenes or inactivated tumor-suppressor genes remain pre-cancerous and asymptomatic until elusive mechanisms transform them into cancer cells. We discovered that PITX1 and SOX2 become expressed when skin epithelial cells form squamous cell carcinomas (SCCs), and propose to determine how their expression is regulated, and whether and how they reprogram pre-cancerous epithelial cells into SCC cells. Answers to these questions will improve the mechanistic understanding of tumor promotion and reveal novel approaches to prevent or treat SCCs, which kill >20,000 patients in the United States each year.

PI_NAMEs: SCHOBER, MARKUS  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: ATAC-seq;Binding;Biological Assay;cancer cell;carcinogenesis;Carcinoma;Cell Nucleus;cell transformation;Cells;checkpoint inhibition;Chemicals;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;chromatin immunoprecipitation;chromosome conformation capture;Clonal Expansion;Cutaneous;Data;Development;Disease;Enhancers;epidermal stem cell;Epigenetic Process;Epithelial Cells;epithelial stem cell;Esophagus;Event;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;Genetic Transcription;genome-wide analysis;Genomics;Growth;Heterogeneity;Human;human model;improved;Inflammation;insight;Link;loss of function;Lung;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutation;Mutation Detection;novel strategies;Oncogenic;organ transplant recipient;Pancreas;Patients;Phosphorylation;Physiological;Positioning Attribute;premalignant;Premalignant Cell;prevent;Process;programs;promoter;Proto-Oncogenes;Regulatory Element;Reporter;Repression;Research;Resected;response;Role;RUNX1 gene;self-renewal;Signal Pathway;Signal Transduction;Site;Skin;Skin Carcinogenesis;Squamous cell carcinoma;Squamous Differentiation;stem cells;stemness;Testing;Therapeutic;Tissues;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptional reprogramming;transcriptome;transcriptome sequencing;Transducers;tumor;tumor growth;tumor initiation;Tumor Promotion;Tumor Suppressor Genes;United States;Visualization;wound

PROJECT_TITLE: Roles and regulation of transcriptional reprogramming in squamous carcinogenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  The goal of the Systems Marketing Analysis for Research Translation (SMART) Innovation Program is to accelerate the translation of known, effective interventions into practice and at a speed and reach that can significantly close regional gaps in health. The project does this by engaging clinical research teams in a structured process for understanding and identifying the drivers of health outcomes.

PI_NAMEs: BIROSCAK, BRIAN JOSEPH;HOVMAND, PETER SVEND (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Acceleration;Address;Advanced Development;Advocate;Area;Benchmarking;beneficiary;Calibration;Case Study;Clinical;Clinical effectiveness;Clinical Research;Clinical Sciences;clinical translation;Collaborations;commercialization;Communities;Community Developments;community setting;Data;design;Dissemination and Implementation;dynamic system;Educational workshop;effective intervention;Effectiveness;effectiveness research;Engineering;Equity;evidence base;experience;follow-up;Goals;Health;health care delivery;health disparity;health equity;health equity promotion;health inequalities;implementation context;implementation design;implementation outcomes;implementation strategy;improved;innovation;Intervention;Investments;Lead;learning progression;manufacture;Marketing;Measurable;medication compliance;Methods;model building;Modeling;models and simulation;novel;Ohio;Outcome;Output;patient navigator;Patients;Performance;Phase;population health;Process;Program Evaluation;programs;Provider;Proxy;Public Health;public health intervention;Reduce health disparities;Research;Research Personnel;Research Project Grants;research study;Risk;scale up;screening;Services;Social Marketing;Speed;Structure;Suicide;System;Testing;Thinking;tool;Translational Research;translational research program;Translations;Violence;Work

PROJECT_TITLE: Clinical and Translational Science Collaborative of Northern Ohio, Systems Marketing Analysis for Research Translation (SMART) Innovation Program