NIH_SPENDING_CATS: Chronic Pain;Hematology;Infectious Diseases;Lung;Neurosciences;Pain Research;Sepsis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PUBLIC HEALTH RELEVANCE Sepsis is a life-threatening consequence of infection that can cause shock, organ failure, and death. Our preliminary studies suggest that during bacterial sepsis, links between a receptor in the nervous system, TRPV1, and cells of immune system are responsible for strong anti-inflammatory and protective effects of two lipids, N-oleoyl dopamine (OLDA) and N-arachidonoyl dopamine (NADA). We will further investigate the anti- inflammatory and protective mechanisms of OLDA and NADA, with the long-term goal to define therapeutic targets for sepsis and other inflammatory processes based on this novel neuroimmune link.

PI_NAMEs: HELLMAN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abdomen;Ablation;Acute;Acute Lung Injury;Adult;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Autonomic nervous system;Bacteremia;beta-2 Adrenergic Receptors;Blood;Bone Marrow;Brain;Brain region;cecal ligation puncture;Cells;Central Nervous System;Cessation of life;Chemical Sympathectomy;chemokine;Chimera organism;CNR1 gene;cytokine;Data;Dopamine;Endotoxemia;Exhibits;functional outcomes;Goals;Hippocampus;Homeostasis;Hour;Hypothalamic structure;Immune;Immune response;Immune system;Immunomodulators;immunoregulation;improved;Infection;Inflammation;Inflammatory;inflammatory pain;Inflammatory Response;Injections;Injury;Interleukin-10;Intra-abdominal;knock-down;Knockout Mice;Life;Link;Lipids;Location;Lumbar spinal cord structure;lung injury;Mediating;Midbrain structure;monocyte;mouse model;Mus;N-arachidonoyl dopamine;Nervous System;Neurocognitive;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;Neuropeptides;new therapeutic target;novel;Organ failure;organ injury;Outcome;Peptides;Peripheral Nervous System;Plasma;Play;Pneumonia;polymicrobial sepsis;Population;Process;Production;Propranolol;protective effect;Public Health;public health relevance;Pulmonary Edema;receptor;Regulation;Reporting;Resolution;Role;Sepsis;septic;Shock;Staphylococcus aureus;Substance P;Sympathetic Nervous System;TACR1 gene;therapeutic target;therapy development;TRPV1 gene;Up-Regulation;Vanilloid;Wild Type Mouse

PROJECT_TITLE: TRPV1-dependent neuro-immune modulation and regulation of endogenous acyl-dopamines in sepsis and acute inflammation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: DUARTE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Bariatric surgery efficiently and sustainably ameliorates the symptoms of obesity and its complications, including type 2 diabetes and non-alcoholic fatty liver disease, but the precise mechanisms by which the positive effects of bariatric surgery are conferred remain unclear. We propose to leverage our unique surgical mouse models and state-of-the-art technology to examine the role of bile acids in mediating the beneficial effects of bariatric surgery. The results of our studies will provide novel mechanistic insights that may lead to a new generation of cost-effective, non-invasive therapies for obesity and its complications.

PI_NAMEs: HUANG, WENDONG  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: absorption;Affect;Animal Model;bariatric surgery;Bariatrics;Bile Acid Biosynthesis Pathway;Bile Acids;Body Weight decreased;Circulation;clinical practice;cost;cost effective;cost effective treatment;CYP8B1 gene;Data;Dependovirus;Development;dietary;Disease remission;Down-Regulation;effective therapy;Enterohepatic Circulation;Enzymes;experimental study;Face;fatty liver disease;fecal microbiota;Frequencies;Gastrectomy;Gene Expression;Generations;Genes;Germ-Free;glycemic control;Goals;gut microbiome;gut microbiota;Health;Hepatic;Human;Hydroxylation;improved;Incidence;innovation;insight;Insulin Resistance;Intestines;Knock-out;Knockout Mice;Link;Lipids;Liver;Low Income Population;Measures;Mediating;Metabolic;Metabolic Diseases;microbiota;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;obesity treatment;operation;Operative Surgical Procedures;overexpression;Physiological;Procedures;reduce symptoms;Role;Serum;sham surgery;side effect;Signal Transduction;Supplementation;Taurocholic Acid;Technology;Testing;Therapeutic;tool;Weight Gain

PROJECT_TITLE: Bile acids and metabolic surgery

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Neuroscience Training Program at Mount Sinai provides rigorous, broad-based, individualized and multidisciplinary training to Year 1 and 2 predoctoral students in basic and translational neuroscience research, including research with a disease-focus. The goal of the Program is to enhance the ability of our trainees to acquire critical skillsets necessary for high-quality doctoral dissertation research and a productive and impactful career in the science-related workforce.

PI_NAMEs: HUNTLEY, GEORGE W. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Training Program in Neuroscience


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Immunotherapy;Maternal Health;Microbiome;Nutrition;Pediatric;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Childhood undernutrition is a pervasive problem worldwide, resulting in reduced linear growth (stunting), increased risk of disease and cognitive defects that persist into adulthood. Maternal health profoundly influences fetal and childhood development, and mothers that are stunted are more likely to give birth to stunted children. Because gut microbes influence growth and immune function, we propose to investigate the role of the maternal microbiota in shaping offspring health, with the goal of identifying specific microbial species and immune pathways for targeted intervention to ameliorate the global burden of undernutrition.

PI_NAMEs: COWARDIN, CARRIE ADELINE (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 16S ribosomal RNA sequencing;adaptive immunity;Address;Adoptive Transfer;Adult;Age;Animals;B-Lymphocytes;Behavior Control;Birth;Body Weight decreased;bone;Bone Growth;Breeding;Cell Physiology;Cells;Cessation of life;Characteristics;Chemicals;chemokine;Child;Child Health;Childbirth;Childhood;Cognitive;Cognitive deficits;cognitive function;Communicable Diseases;Communities;Complication;Data;Defect;Development;disorder risk;Education;Environment;experience;experimental study;fetal;Flow Cytometry;Fostering;Gene Expression Profiling;Germ-Free;global health;Gnotobiotic;Goals;Growth;gut microbes;gut microbiome;gut microbiota;Health;Heterozygote;Homozygote;Human;Immune;immune activation;immune function;Immune response;Immunity;Immunotherapeutic agent;improved;Infant Health;Infrastructure;innovation;insight;intergenerational;Intervention;Investigation;Life;Lymphoid;Lymphopoiesis;machine learning algorithm;Malnutrition;Maternal Health;maternal immune system;maternal microbiome;maternal microbiota;Mediating;member;Metabolic;Metabolic Diseases;Microbe;microbial;microbial community;microbiome;microbiota;Modeling;Mothers;mouse model;Mus;Neonatal;novel strategies;offspring;Omenn syndrome;Partner in relationship;Pathway interactions;Phenotype;Physiological;Play;postnatal;postnatal period;Pregnancy;prenatal;Probiotics;Productivity;progenitor;pup;Rag1 Mouse;random forest;Research;Risk;Role;Shapes;Signal Pathway;Sorting;stool sample;Syndrome;Systems Biology;T cell response;T cell therapy;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time;tomography;transmission process;Universities;Virginia;Vulnerable Populations;Weight;Work

PROJECT_TITLE: The maternal microbiome in childhood growth and immunity during undernutrition

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goal of this application is to understand how the epithelial-specific ER stress sensor IRE1b (ERN2) and its ubiquitously expressed paralogue IRE1a (ERN1) contribute to intestinal homeostasis and host defense. This will be informative for how barrier epithelial cells interact with the lumenal and sub-epithelial microenvironment, and the biology of events implicated in the pathogenesis of the inflammatory bowel diseases. We also note these studies will uncover general rules underlying the activation of key ER stress sensors, and how the ER stress response affects the development and differentiation of goblet cells to produce a functional mucus barrier: a topic of general relevance to physiology of the alimentary tract and the development of human disease.

PI_NAMEs: GREY, MICHAEL J;LENCER, WAYNE I (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: acute infection;Address;Affect;Animals;Area;Asthma;Attenuated;Binding;Biochemical;biological adaptation to stress;Biology;biophysical techniques;cell assembly;Cell Communication;Cell Differentiation process;Cell Line;Cell Physiology;Cells;Cellular Stress;Cholera Toxin;Chronic;Citrobacter rodentium;Colon;Data;Defect;Defense Mechanisms;Development;Disease;dysbiosis;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosomes;Environment;Epithelial Cells;Epithelium;Event;extracellular;Functional disorder;gastrointestinal epithelium;Gastrointestinal tract structure;Germ-Free;Goals;Goblet Cells;Grant;gut microbes;gut microbiota;Gut Mucosa;Host Defense;host microbiota;Human;human disease;Impairment;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;interest;Intestinal Diseases;intestinal homeostasis;Intestines;Invaded;Investigation;Link;Mediator;Membrane;Microbe;microbial;microbiota;Modeling;Molecular;Mucous body substance;Mucous Membrane;Mus;Outcome Study;Output;paralogous gene;pathogen;Pathogenesis;Pathway interactions;Phenocopy;Physiology;Post-Translational Protein Processing;Proteins;Recombinant Proteins;reconstitution;Recovery;response;Role;sensor;Sequence Homology;Shapes;Signal Transduction;Stress;Structure;Surface;Taxonomy;Testing;therapeutic target;Toxin;Ulcerative Colitis;Vibrio cholerae;Work

PROJECT_TITLE: Mechanism of action for the epithelial-specific ER stress sensor IRE1β in regulating intestinal homeostasis and host defense

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(02)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: Washington

ORG_NAME: NEUROENE THERAPEUTICS INC

ORG_STATE: DC

PHR: Narrative Neuroene Therapeutics has a clinical lead antiseizure drug (ASD) that is fast-acting, broad-spectrum, well- tolerated, stable at room temperature, and protect mitochondrial and neuronal health. This compound has potential for stabilizing and overriding cascading effects due to poisoning by organophosphate (OP) nerve agents. If successful, our drug could be a dual-purpose ASD for acute settings and to reduce long-term sequela associated with OP poisoning. Neuroene's clinical candidate could be made widely available commercially to improve the United States' health security posture due our commercial indications for pharmacoresistant seizures, while being available during a public health emergency or bio-incident.

PI_NAMEs: CHAN, SHERINE S (contact)

PROGRAM_OFFICER_NAME: YEUNG, DAVID

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Acute;Adjuvant;analog;Animal Model;Anticonvulsants;Atropine;authority;Benzodiazepines;Brain;Caring;chemical countermeasure;Chemical Warfare Agents;Chemical Weapons;Chemicals;Chronic;Clinical;clinical candidate;Cognitive;Complex;Dose;Dose Limiting;drug candidate;Drug usage;Dryness;Emergency treatment;Ensure;Enzyme Inhibition;Epilepsy;Event;fluorophosphate;Frequencies;Funding;GABA Receptor;gamma-Aminobutyric Acid;Health;improved;Isoflurophate;Lead;Life;long-term sequelae;Maximum Tolerated Dose;Measures;Membrane Potentials;Midazolam;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular Target;Mus;Muscarinic Acetylcholine Receptor;National Institute of Allergy and Infectious Disease;nerve agent;Neurologic;Neurons;neuroprotection;novel;Ohio;Oral;Organ;organophosphate poisoning;Organophosphates;Outcome;Oxidative Stress;Parkinson Disease;Pathway interactions;Patients;Penetration;Pesticides;Pharmaceutical Preparations;Poisoning;Posture;prevent;Production;programs;Property;public health emergency;Rattus;Research;research and development;Rodent;screening program;Security;sedative;Seizures;side effect;Site;Soman;standard care;standard of care;Status Epilepticus;Temperature;Testing;Therapeutic;Time;Toxic effect;United States;United States National Institutes of Health;Universities;Utah;vitamin analog;Vitamin K;Work

PROJECT_TITLE: A Vitamin K analog countermeasure for organophosphate poisoning


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Drug resistance mutations from lack of patient adherence to daily dosing regimens reduce the effectiveness of HIV-1 treatment; therefore, potent inhibitors with the potential to be long-acting are needed to combat this problem. Islatravir (EFdA) is a promising potent, long-acting antiviral that targets HIV-1 reverse transcriptase, an essential enzyme in the HIV-1 replication cycle. I will study a drug mutation that causes resistance to one type of reverse transcriptase inhibitor but increases susceptibility to EFdA, which will aid in developing optimized combination treatments for future HIV-1 therapies.

PI_NAMEs: SNYDER, ALEXA ANNE (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: 2'-deoxyadenosine;Action Potentials;Active Sites;Affect;antagonist;Anti-viral Agents;antiretroviral therapy;Binding;Biochemical;Biological Assay;Biology;Categories;Cells;Clinical Trials;combat;Combined Modality Therapy;Complex;Computer software;crosslink;Data;design;Development;Distant;DNA;Dose;Drug Combinations;Drug resistance;drug resistance development;ds-DNA;Effectiveness;Environment;Enzymes;Equipment;Excision;experimental study;Future;HIV-1;Hydrophobicity;Hydroxyl Radical;Hypersensitivity;Individual;inhibitor;insight;Kinetics;Lead;Methods;Molecular;mutant;Mutation;NNRTI-resistance;non-nucleoside reverse transcriptase inhibitors;novel strategies;Nucleic Acids;nucleoside analog;Nucleosides;Patient Compliance;Patient Noncompliance;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase III Clinical Trials;Polymerase;Predisposition;prevent;Protocols documentation;Regimen;Resistance;resistance mutation;Reverse Transcriptase Inhibitors;RNA-Directed DNA Polymerase;Role;Scientist;Site;Structure;synergism;Techniques;Testing;Training;Treatment Efficacy;treatment strategy;tripolyphosphate;Viral;Viral Drug Resistance;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of HIV-1 Hypersensitivity to Islatravir

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-H(20)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The culmination of the proposal will be a systematic and comprehensive approach for interpreting noncoding variants to understand the underlying mechanisms that link genetics to gene expression and causes of human disease. That outcome will transform human disease studies by allowing noncoding sequence variation to inform genetic causes of disease, both in novel disease gene discovery studies and in the diagnostic interpretation of individual patient genomes.

PI_NAMEs: ALLEN, ANDREW S (contact);MAJOROS, WILLIAM ;PAGE, CHARLES DAVID

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Biological Assay;Catalogs;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Computational Biology;Coupled;Coupling;Data;deep neural network;design;Diagnostic;Disease;End Point Assay;Epigenetic Process;Evolution;experience;Experimental Designs;experimental study;Explosion;flexibility;gene discovery;Gene Expression;Gene Expression Regulation;Genetic;Genetic Code;Genetic Determinism;genetic variant;Genetic Variation;Genome;genome sequencing;Genomic Segment;Goals;Health;health determinants;Human;human disease;Human Genome;improved;Incidence;individual patient;Link;Machine Learning;machine learning method;machine learning model;Measures;member;Methods;Modeling;models and simulation;Mutagenesis;Neural Network Simulation;novel;Outcome;Output;Parameter Estimation;Pathogenicity;Patients;Phenotype;Population;Population Genetics;predictive modeling;Prevention;Recommendation;Regulatory Element;Risk;Sample Size;Site;Software Tools;statistical and machine learning;Statistical Models;success;Testing;tool;Untranslated RNA;Update;Variant;whole genome

PROJECT_TITLE: Design, prediction, and prioritization of systematic perturbations of the human genome


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Germline stem cells (GSCs) are arguably the most fundamental cell type required for animal reproduction because these cells both maintain the germline throughout the animal’s life and produce the cells that go on to form either sperm or eggs. Remarkably, several key GSC regulatory genes are under strong natural selection for protein diversification between species of Drosophila. Our proposed study is aimed at identifying the functional consequences and correlated evolutionary pressures associated with the rapid protein evolution of bag of marbles, the key switch gene for GSC differentiation and its interaction with the intracellular bacterial symbiont, Wolbachia pipientis.

PI_NAMEs: AQUADRO, CHARLES F (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Age;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Animals;Automobile Driving;Bacteria;barrier to testing;Cell Communication;Cell Differentiation process;Cell Maintenance;cell type;Cells;Characteristics;comparative;Computer Models;Conflict (Psychology);CRISPR/Cas technology;Culicidae;Development;Developmental Process;Diptera;driving force;Drosophila genus;Drosophila melanogaster;egg;endosymbiont;Evolution;Female;female fertility;Fertility;Fertility Disorders;fly;Fossils;Funding;Gametogenesis;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Germ Cells;Germ Lines;germline stem cells;Hand;human pathogen;improved;Infection;Infertility;innovation;Insecta;insight;Learning;Life;loss of function;male;Malignant Neoplasms;Marble;Modeling;Molecular;mutant;Mutation;Natural Selections;Nature;novel;null mutation;Parasites;Pattern;pressure;Process;Proteins;reference genome;Regulation;Regulator Genes;Reproduction;reproductive;Role;self-renewal;Shapes;Signal Transduction;sperm cell;stem cell differentiation;stem cell division;stem cell function;stem cell genes;stem cells;Surveys;Switch Genes;symbiont;Testing;Time;tool;transcriptome sequencing;transmission process;Variant;Virus;Wolbachia

PROJECT_TITLE: Adaptive Protein Evolution of the Drosophila Germline Stem Cell Gene Bag of Marbles

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  Platelets are small cells that circulate in blood for about ten days, and their primary function is to initiate and promote hemostasis – clot formation at a site of blood vessel injury to prevent blood loss which requires rapid activation of platelet molecular and cellular responses to drive clotting; conversely, platelet hyper- reactivity creates a pro-thrombotic state with increased risk of blood clots that can block vessels, a major clinical concern. Therefore, control of platelet activity is a high impact research goal broadly affecting many disease states as well as aging; however, thorough understanding of the molecular and cellular mechanisms that regulate platelet reactivity remains incomplete. In this study we will investigate new molecular regulators of platelet reactivity in healthy plasma we have identified and begun to characterize, which affect specific but poorly understood platelet responses, including their mechanisms of action, roles in platelet functional response, and contributions to hemostasis and thrombotic potential, with broad implications across the spectrum of clinical management of bleeding and clotting.

PI_NAMEs: GOLDFINGER, LAWRENCE E (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Affect;Aging;Area;Attention;Automobile Driving;Biology;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Cell Physiology;Cells;Circulation;Clinical;clinical application;Clinical Management;clinical translation;clinically significant;Coagulation Process;Complex;Data;Development;Disease;Docking;Environment;Expenditure;functional outcomes;Gene Expression;gene function;genome wide association study;Goals;Growth Factor;Hemorrhage;Hemostatic function;Homeostasis;Hormone imbalance;Hormones;Human;in vivo;inhibitor;Injury;innovation;Maps;Mediating;Megakaryocytes;Messenger RNA;MicroRNAs;Modeling;Molecular;mouse model;Mus;Natural regeneration;Outcome;Outcome Study;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Physiological;Physiology;Plasma;Platelet Activation;platelet function;prevent;Process;protein expression;Proteins;Proteome;proteostasis;Regulation;Research;Resources;response;Rest;Risk;RNA;Role;Series;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Site;Somatotropin;Testing;Thrombosis;thrombotic;Time;Translation Initiation;translational applications;Translations

PROJECT_TITLE: Function and regulation of constitutive protein translation in platelets

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Impaired sentence processing is one of the major difficulties experienced by many persons with aphasia. In this project, persons with aphasia will participate in a set of implicit structural priming experiments and a treatment study with the goals of improving their independent and lasting sentence production and comprehension. Findings from this project will lead to the development of a novel, implicit-learning based treatment for communication deficits in aphasia.

PI_NAMEs: LEE, JIYEON  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TITLE: Implicit Structural Priming as a Treatment Component in Aphasia


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Basophils and dendritic cells are white blood cells that release chemicals linked to causing allergy symptoms. We have evidence for a unique interaction between these cells and so-called epithelial cells –a kind of cell common to organs, such as the skin and lung. By better understanding this interaction, we might learn why allergies persist and possibly develop new strategies to treat allergic diseases in general.!

PI_NAMEs: SCHROEDER, JOHN T. (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: A549;Address;Affect;Affinity;Allergens;Allergic;Allergic Disease;Antigens;Asthma;Atopic Dermatitis;Autoimmunity;Basophils;Binding;Blood Cells;Cell Adhesion;Cell Line;Cells;Cellular Structures;chemical release;Child;Chronic;crosslink;cytokine;Data;Dendritic Cells;Disease;Disease susceptibility;Epithelial Cells;Food;Galactose Binding Lectin;Galectin 3;genetic manipulation;Goals;Histamine;Histamine Release;Human;Hypersensitivity;IgE;Immobilization;Immune;Immune response;Immunologic Receptors;immunoregulation;Impairment;in vivo;Inflammation Mediators;Inflammatory;insight;Interferon alpha;Interferon Type I;Interleukin-13;Interleukin-4;Interleukin-6;Investigation;Learning;Lectin;Leukocytes;Leukotriene C4;Ligand Binding;Link;Lung;Lupus Nephritis;Malignant Neoplasms;mast cell;Mediating;Mediator;Microspheres;Modeling;mouse model;Mus;Myelogenous;Organ;Pathogenesis;Pathway interactions;Pattern;Population;prevent;Property;Proteins;receptor;receptor binding;Regulation;Reporting;response;Signal Pathway;Signal Transduction;Skin;small hairpin RNA;Source;Stimulus;Symptoms;Testing;TNF gene;Translating;TSLP gene;United States;Urticaria;Virus;wound healing

PROJECT_TITLE: Galectins in Modulating Immune Responsiveness of IgE-bearing Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: This project will use directed evolution to examine the origin and consequences of multicellular development. This research will provide unique insight into an evolutionary step of profound importance, and will identify conserved evolutionary principles that are relevant to the origin and progression of numerous diseases, including tumorigenesis in cancer and biofilm dynamics in infectious disease.

PI_NAMEs: RATCLIFF, WILLIAM CROFT (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3-Dimensional;Age;Behavior;Biological Models;Biophysics;cell age;cell behavior;Cell Differentiation process;cell type;Cells;cellular development;Cellular Structures;Cellularity;Communicable Diseases;Complex;Data;Development;Developmental Biology;Directed Molecular Evolution;Disease;Evolution;Extinction;Gene Expression;Generations;insight;Knowledge;laboratory experiment;Location;Malignant Neoplasms;Mechanics;Microbial Biofilms;Modeling;Molecular Chaperones;novel;Organism;Pattern;programs;Proteins;Research;simulation;Specific qualifier value;tumorigenesis;Work;Yeasts

PROJECT_TITLE: Using directed evolution to study the origins of multicellular development.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: CHICAGO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Eye diseases including glaucoma, macular degeneration, and diabetic retinopathy impose a high and increasing financial and personal burden on Americans, especially the elderly. The Northwestern University Multidisciplinary Vision Training Program equips highly motivated pre-doctoral and post-doctoral students with the skills necessary to perform research into the basic mechanisms of these diseases and to understand their effects on vision.

PI_NAMEs: DEVRIES, STEVEN H (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Multidisciplinary Visual Sciences Training Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Substance use abuse and dependence are especially complex disorders, with innumerable genetic and environmental risk factors, highly variable patterns of onset, offset and comorbidity with psychiatric disorders, cardiovascular disease and cancer. This project will develop Mendelian randomization based statistical methods and software and apply them to unique data from the Netherlands on genomic methylation. The project will improve understanding of the causes and effects of substance abuse and dependence, and how best to prevent and treat these disorders and their sequelae.

PI_NAMEs: NEALE, MICHAEL CHURTON (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: addiction;Address;Adult;Age;Alcohol consumption;Alcohols;biobank;Birth;Cardiovascular Diseases;Cigarette;comorbidity;Companions;Complex;Computer software;Data;Data Analyses;Databases;Dependence;design;Development;Disease;DNA Methylation;Educational workshop;effective intervention;effective therapy;Environment;Environmental Risk Factor;Etiology;evidence base;Family;Genes;Genetic;genetic risk factor;genome wide association study;genomic data;Genomics;Genotype;handbook;improved;Individual;instrument;International;Malignant Neoplasms;Marijuana;marijuana use;Measures;Mendelian randomization;Mental disorders;Methodology;Methods;Methylation;methylomics;Modeling;Nature;Netherlands;network models;Nicotine Dependence;non-smoker;novel;online course;Partner in relationship;Pathway interactions;Pattern;Phenotype;pleiotropism;Policy Maker;prevent;Prevention;Process;psychiatric symptom;Publications;Relapse;Relaxation;Research Design;Research Personnel;Risk Factors;Sampling;sex;Sex Differences;Site;Smoker;Smoking;Smoking Behavior;Statistical Methods;Substance abuse problem;Substance Addiction;substance use;Symptoms;System;Teaching Method;Testing;Time;Tobacco smoking behavior;trait;Twin Multiple Birth;Variant;web site;Work

PROJECT_TITLE: Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Human Genome;Kidney Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Diabetic nephropathy (DN) is a complex, heterogeneous complication of diabetes that is characterized by progressive renal decline, the genetic basis of which is not well understood. To advance this area of research, we’ve developed an innovative family-based approach to accelerate gene discovery in DN that leverages one of the world’s largest and well-characterized cohorts of diabetic patients with rapid progression of renal decline; using this approach, we’ve identified putative disease-causing variants in 2 genes not previously known to contribute to DN. The proposed research will determine the functional roles of these genes in rapid renal decline and expand upon this study by performing WES-based gene discovery in additional, newly identified high-risk pedigrees enriched for rapid renal decline and investigating the biological impact of the identified candidate genes.

PI_NAMEs: PEZZOLESI, MARCUS GUY (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;adiponectin;Adipose tissue;Affect;Anti-diabetic Drugs;Anti-Inflammatory Agents;Apoptotic;Area;biobank;Biological;Biological Assay;Biology;Candidate Disease Gene;candidate identification;Catalogs;Clinical;Code;cohort;Complex;Complications of Diabetes Mellitus;Computerized Medical Record;conditional knockout;Data;Databases;design;Deterioration;Development;Diabetes Mellitus;Diabetic Nephropathy;diabetic patient;Disease;disease-causing mutation;Dominant-Negative Mutation;drug discovery;epidemiology study;exome sequencing;Extracellular Matrix Proteins;Family;Fraser syndrome;gene discovery;Genealogy;Genes;Genetic;genetic architecture;genetic pedigree;Genetic study;genetic variant;genome wide association study;genome-wide;Goals;high risk;Hormones;Human;improved;In Vitro;in vivo;Individual;innovation;insight;Kidney;Kidney Diseases;link protein;Longitudinal Studies;Mus;Mutation;novel;Pathway interactions;Patients;Phenotype;Pilot Projects;population based;Population Database;Predisposition;prevent;Property;Proteins;Publishing;Recording of previous events;Renal function;Reporting;Research;Resources;Risk;Role;Shapes;Susceptibility Gene;tool;Universities;Utah;Variant

PROJECT_TITLE: Genetic and Functional Analysis of Rapid Renal Decline in Diabetes: A Family-based Approach to Accelerate Gene Discovery

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: FLUSHING

ORG_NAME: QUEENS COLLEGE

PHR: Project Narrative – Iodine Catalyzed Cross-Coupling Reactions The proposal aims at developing the mechanism for green synthetic protocols of a few key chemical bonds, functional groups, and frameworks prevalently appearing in modern drug molecules. It focuses on the study of coupling reactions for carbon-carbon and carbon-nitrogen bond formations. The proposed iodine-catalyzed cross-couplings have obvious advantages over the transition metal-catalyzed coupling protocols widely employed in the drug molecule synthesis for using an inexpensive green catalyst and effectively avoiding toxic metal catalyst residues in final drug molecules. The new methods are expected to serve the critical need for medicinal chemists in the course of preparing the corresponding chemical bonds and frameworks for novel therapeutics.

PI_NAMEs: CHEN, YU  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative: Successful completion of the proposed studies will identify novel mutations underlying the disease, refine the pathogenesis model of IgAN, and provide the knowledge necessary to translate our new genetic discoveries into clinical applications.

PI_NAMEs: GHARAVI, ALI G (contact);NOVAK, JAN ;SCOLARI, FRANCESCO

PROJECT_TERMS: adaptive immunity;Adoptive Transfer;African;Aging;Animal Model;Antigen-Antibody Complex;Asian population;attenuation;B-Lymphocytes;Back;Biochemical;Biochemistry;Book Chapters;Caucasians;Cell Line;Cells;Characteristics;Circulation;clinical application;Clinical Data;cohort;Colitis;Complex;CRISPR/Cas technology;cytokine;Data;Defect;Deposition;Development;Diagnosis;Disease;druggable target;exome;exome sequencing;experimental study;Family;Galactose;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;genome wide association study;Genomics;Genotype;Glomerulonephritis;glycosylation;Greater sac of peritoneum;Heritability;Homing;Human;IGA Glomerulonephritis;IgA1;Immune;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologics;Immunology;Impairment;Individual;Inflammatory;Injury to Kidney;insight;Integration Host Factors;intestinal epithelium;Kidney;kidney biopsy;Kidney Failure;Knockout Mice;Knowledge;Lead;Maps;Mediating;Modeling;Molecular;Molecular Analysis;mouse model;Mucins;Mus;Mutation;N-Acetylgalactosaminyltransferases;Natural Immunity;novel;Paper;Pathogenesis;Pathway interactions;Patients;Polysaccharides;Population;proband;Production;Publishing;Quantitative Trait Loci;rare variant;Recombinants;recruit;Renal function;Research Proposals;response;Risk;Role;Serum;Sodium Dextran Sulfate;Spleen;Sterility;Stimulus;trafficking;transcriptome;transcriptomics;Translating;Validation;Variant

PROJECT_TITLE: Elucidating IgA nephropathy through Genetic Studies of IgA1 Glycosylation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: 8. PROJECT NARRATIVE This proposal is a renewal application for years 11-15 of a 5-year National Research Service Award Institutional Research Grant to support a training program in HIV Epidemiology and Prevention Sciences at the Johns Hopkins Bloomberg School of Public Health (BSPH) and the Johns Hopkins School of Medicine (SOM) entitled the “Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program.” We are requesting support for 3 pre- and 4 post-doctoral trainees, who will be trained in three parallel training tracks: HIV Epidemiology and Implementation Science Methods; HIV Clinical and Laboratory Sciences; and HIV Prevention Sciences.

PI_NAMEs: MEHTA, SHRUTI H (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Elevated large artery stiffness with aging contributes to cardiovascular disease (CVD) events such as myocardial infarction, stroke and CVD death in part from isolated systolic hypertension (ISH, (i.e., increased systolic but not diastolic blood pressure). Sympathetic nerve activity (SNA) also increases with advancing age but it is unknown if SNA contributes directly to large artery stiffness in older adults with ISH. Therefore, successful completion of the proposed aims will have a significant clinical impact by identifying SNA as a novel therapeutic target for the treatment of elevated aortic and carotid stiffness in older adults with ISH.

PI_NAMEs: PIERCE, GARY L. (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acute;Adult;Age;age related;aged;Aging;Aorta;arterial stiffness;Arteries;arteriole;Attenuated;Blood flow;Blood Pressure;Brain;calcification;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Carotid Arteries;Central Artery;cerebrovascular;Cessation of life;Chronic;Clinical;Clonidine;Collagen;Data;Development;Diastolic blood pressure;Double-Blind Method;effectiveness evaluation;Elasticity;Elastin;Elderly;Enrollment;Event;experimental study;Femur;Goals;hemodynamics;Human;human old age (65+);Hypertension;hypoperfusion;indexing;insight;Isolated systolic hypertension;Left Ventricular Hypertrophy;Lower Body Negative Pressure;Measures;Medial;Mediating;men;middle age;muscle hypertrophy;Myocardial Infarction;Nerve;new therapeutic target;novel therapeutic intervention;older adult;older men;older women;Oral;Organ;Penetration;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiologic pulse;Placebo Control;prehypertension;pressure;Publishing;Pulse Pressure;Randomized;Regulation;Research;Smooth Muscle;Stroke;therapeutic target;Thick;white matter damage;Woman

PROJECT_TITLE: Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic Hypertension

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: We have developed and clinically translated the combination of trabectedin and irinotecan as an EWS-FLI1 targeted therapy for Ewing sarcoma. While the clinical evaluation of this combination is promising and multiple tumor regressions have been observed, the activity has been limited by what appears to be intrinsic mechanisms of resistance. The goal of the current study is to exploit these mechanisms to develop novel EWS-FLI1 directed combination therapies with improved activity and less toxicity.

PI_NAMEs: GROHAR, PATRICK J (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: actinomycin;Binding;Biological Assay;Biology;Cell Nucleolus;Cell Nucleus;Cell Proliferation;Cell Survival;cell type;Cells;Chimeric Proteins;Chromatin;Chromatin Structure;Clinic;Clinical;Clinical Data;Clinical Trials;Combined Modality Therapy;Cytoprotection;Data;Dependence;Development;Disease;DNA;DNA Binding;DNA Binding Agent;DNA Damage;DNA Minor Groove Binding;Dose;Doxorubicin;driver mutation;Drug resistance;effective therapy;Enhancers;Epigenetic Process;epigenetic silencing;Etoposide;Ewings sarcoma;EWS-FLI1 fusion protein;EWSR1 gene;FLI1 Transcription Factor;Genes;Genetic Transcription;Genome;global run on sequencing;Goals;Heat-Shock Proteins 70;Impairment;improved;improved outcome;in vivo;inhibitor;insight;irinotecan;Malignant Neoplasms;Microsatellite Repeats;Modeling;Mutation;Normal Cell;novel;novel strategies;Nucleotides;Oncogenes;Oncogenic;Output;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase Transition;Poison;pre-clinical;Proteins;Proteomics;Recovery;recruit;Recurrence;Relapse;Reporting;research clinical testing;resistance mechanism;response;Response Elements;Site;success;targeted agent;targeted treatment;Testing;Therapeutic;Toxic effect;transcription factor;Translating;Treatment Efficacy;tumor;tumor growth;Ultraviolet Rays

PROJECT_TITLE: The interface of transcription, DNA damage and epigenetics: A therapeutic vulnerability of the EWS-FLI1 transcription factor

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative The proposed program aims to develop new methods for the preparation of structures and compounds of potential importance to medicinal chemistry. Transition metal-catalyzed, organocatalytic and dual catalytic processes that target the formation of carbon-heteroatom, including carbon-fluorine bonds, are proposed. Studies unravelling the mechanistic underpinnings of these reactions, including those leveraging modern data science, will be undertaken.

PI_NAMEs: TOSTE, F. DEAN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Methods for Selective Organic Synthesis based on Ionic Catalysts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Narrative  This proposal focuses on learning how small immune cells known as platelets stimulate abnormal changes in monocytes causing lasting infection of HIV-1 in the brain. This new information regarding how platelets enhance the infection of the brain in people living with HIV is expected to assist in achieving complete elimination of HIV.

PI_NAMEs: MAGGIRWAR, SANJAY B. (contact);PAIARDINI, MIRKO

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Anatomy;antiretroviral therapy;Basic Science;Blood - brain barrier anatomy;Blood Platelets;Blood Vessels;Brain;CCL2 gene;CD14 gene;Cells;Central Nervous System;Cerebrospinal Fluid;Complex;Data;Development;Event;FCGR3B gene;HIV;HIV Infections;HIV-1;Immune;in vivo;Infection;innovation;insight;Interruption;Intervention;Kinetics;Learning;Macaca mulatta;Macrophage;Maintenance;Mammalian Cell;Mediating;Microglia;migration;Modeling;monocyte;Myeloid Cells;neuroinflammation;novel;Peripheral;permissiveness;Persons;pharmacologic;Phase;Phenotype;pre-clinical research;Predisposition;prevent;Productivity;Research;Resistance;response;Role;SIV;Testing;trafficking;transmission process;Viral;viral rebound;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Revealing the role of platelets in promoting HIV reservoir seeding and persistence in the CNS-resident myeloid cells


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative The late evolutionary emergence of two specialized projection neurons in the hominid insular cortex, von Economo neurons and fork cells, suggests these neurons may be the neuronal correlate of human-like social intelligence, while their malfunctions are associated with devastating neuropsychiatric diseases including schizophrenia, dementia, autism, and Alzheimer disease. A recent finding that these specialized projection neurons also occur in macaque anterior insula provides an unprecedented opportunity for functional characterization of these unique neurons in the laboratory. By complementing the technical strength and unique resources of two collaborating labs in China and in USA, we scale up a cost-efficient, multidisciplinary approach to macaque anterior insula to decipher transcriptomic signatures, physiology and connectivity of these two novel cell types, which will provide unprecedented knowledge and resources to understand human- like social intelligence and related neuropsychiatric conditions.

PI_NAMEs: JIANG, XIAOLONG  (contact)

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Alzheimer's Disease;Animals;Anterior;Area;Atlases;autism spectrum disorder;Back;Behavior;biocytin;Brain;brain cell;Brain region;brain tissue;Budgets;Cell Physiology;cell type;Cells;Characteristics;China;Chinese;cingulate cortex;clinically relevant;Cluster Analysis;Cognitive;cognitive ability;cognitive process;Collaborations;Complex;Conscious;cost;cost effective;cost efficient;Data;Dementia;Dissociation;Electrophysiology (science);Empathy;Endowment;fluorescence imaging;Future;Genes;Genetic;Genetic Markers;Hominidae;Human;infancy;Insula of Reil;Intelligence;interdisciplinary approach;interest;Knowledge;Laboratories;Laboratory Research;Link;Location;Macaca;Maps;Methods;Molecular;Monkeys;Morphology;Neocortex;neural correlate;Neurobiology;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;patch sequencing;Pattern;Physiological;Physiology;Play;Pongidae;preservation;Primates;Property;Protocols documentation;Research;Resources;Rodent;Role;scale up;Schizophrenia;Self Perception;single-cell RNA sequencing;social;Social Behavior;social cognition;Social intelligence;Solid;Stains;Taxonomy;Testing;Time;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Deciphering the transcriptomic signatures, physiology, and connectivity of the specialized morphotypes in macaque insular cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-W(50)R]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: The goal of this application is to enhance the ability of the Johns Hopkins University Center for AIDS Research (CFAR) to nurture and support high-impact HIV research and researchers across a broad range of disciplines and specialties in the multiple divisions of this major research university. The CFAR will recruit, mentor and support new investigators, including members of underrepresented population groups, provide research support services, and leverage the capacity of Johns Hopkins to help end the HIV epidemic in Baltimore and nationally.

PI_NAMEs: CHAISSON, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Area;Award;Baltimore;base;Bioinformatics;Biological Assay;career;Career Mobility;Cities;Clinical;Clinical Pharmacology;Clinical Research;Collaborations;collaboratory;combat;Communication;Communities;community based research;community building;community intervention;community organizations;community partnership;Consultations;data sharing;Development;Discipline;District of Columbia;Electronic Mail;Epidemic;epidemic preparedness;ethnic disparity;experience;Extramural Activities;Faculty;Foundations;Funding;Future;Generations;Goals;Government Agencies;Grant;Health;health disparity;Historically Black Colleges and Universities;HIV;HIV Infections;HIV/AIDS;Immunology;Individual;Information Dissemination;innovation;Institution;instrument;interdisciplinary collaboration;Interest Group;Investments;Laboratories;Leadership;Link;medical schools;medical specialties;Medicine;meetings;member;Mentors;Methods;Mid-Atlantic Region;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Newsletter;next generation;Pathway interactions;Pilot Projects;Population;Population Group;Positioning Attribute;Preparation;Prevention;Productivity;programs;Public Health;Public Health Schools;Publications;racial disparity;recruit;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Scholars Program;School Nursing;Science;Services;social interventions;Specimen;Statistical Methods;symposium;tool;Training;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Update;virology;Vision;web site;Work;working group

PROJECT_TITLE: The Johns Hopkins Center for AIDS Research (JHU CFAR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Microbial infections are likely risk factors for late-onset Alzheimer’s disease. Evidence of infections can be found by aligning DNA fragments from samples collected in humans to microbial reference genomes. This project will leverage large, existing next generation sequencing cohorts of AD cases in controls to explore mechanisms driving microbe-mediated AD risk, including the role of variants in the human genome.

PI_NAMEs: SHERVA, RICHARD  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;acute infection;Affect;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;anti-microbial drug;antimicrobial;Automobile Driving;Bacteria;Biological Markers;Blood;Brain;brain cell;cell type;chronic infection;Cognitive;cognitive function;cohort;Communicable Diseases;Data;design;Diagnosis;Disease;Disease Progression;DNA;DNA Sequence;DNA sequencing;effective therapy;Environmental Risk Factor;Etiology;experimental study;Framingham Heart Study;genetic association;Genetic Materials;genetic risk factor;genetic variant;Genome;Goals;HLA-DRB1;Human;human DNA;Human Genome;human tissue;Immune system;Immunologics;Individual;Infection;infection risk;Infectious Agent;Inflammatory;innovation;Intervention;Late Onset Alzheimer Disease;latent infection;Link;machine learning model;Magnetic Resonance Imaging;Measures;Mediating;Medicine;Microbe;microbial;Microbial Genetics;Molecular;MS4A1 gene;Multiomic Data;neuroimaging;neuroinflammation;neuropathology;next generation sequence data;next generation sequencing;Other Genetics;Participant;pathogen;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;PLCG2 gene;Predisposition;prevent;Process;Quality Control;reference genome;Research Personnel;Risk;Risk Factors;risk variant;Role;Sampling;Senile Plaques;Serotyping;Source;SPI1 gene;Testing;Tissues;trait;TREM2 gene;Variant;Viral;viral DNA;Virus

PROJECT_TITLE: Exploring mechanisms driving microbe-induced AD risk using next generation sequence data.


NIH_SPENDING_CATS: Aging

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The Summer Research Training in Aging for Medical Students Program will accept sixteen medical students between their first and second year of medical school. The program will coordinate with the American Federation for Aging Research to allow both NYU School of Medicine students and students from other medical schools to participate. Students will have nine weeks of research training with experienced research mentors and faculty mentors who will introduce them to clinical geriatrics, didactic sessions on research methods, aging processes and geriatrics, and will be expected to present their research locally as well as at the American Geriatrics Society (AGS) annual meeting.

PI_NAMEs: CHODOSH, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Achievement;Aging;aging related;American;career;Clinical;clinical care;curriculum development;Data;Educational Curriculum;Elderly;Ensure;Evaluation;experience;Financial Support;Future;Geriatrics;Goals;improved;interest;medical schools;Medical Students;meetings;Mentors;Mentorship;older adult;Probability;Professional Organizations;programs;Publications;Qualifying;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Running;Societies;student participation;Students;success;summer research;Surveys;Work


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Genetics;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: A subset of HPV types are the causative agents of cervical cancer and are also associated with head and neck cancers. Our studies focus on the interaction between HPV and the host DNA damage response. Understanding how HPV activates and uses DNA damage response pathways for viral replication has the potential to identify targets that could be important clinically for the treatment of HPV-associated diseases.

PI_NAMEs: MOODY, CARY A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Affect;Anti-viral Agents;Anti-viral Therapy;ATM Signaling Pathway;Basal Cell;Binding;BRCA1 gene;Cell Differentiation process;Cells;Chromatin;chronic infection;Clinical Treatment;Data;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA-dependent protein kinase;Double Strand Break Repair;Ensure;Environment;Episome;Epithelium;extracellular;G2 Phase;Genetic Recombination;Genome;Head and Neck Cancer;Histones;homologous recombination;HPV E7;HPV positive;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Infection;insight;Knowledge;Life Cycle Stages;Link;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Monitor;new therapeutic target;Nonhomologous DNA End Joining;novel therapeutic intervention;Oncoproteins;p53-binding protein 1;Pathogenesis;Pathway interactions;Phase;Phosphotransferases;Plasmids;Play;Process;Productivity;Proteins;Publishing;recombinational repair;recruit;repaired;Repression;response;Role;Shapes;Stratified Epithelium;Surveys;Testing;therapeutic development;ubiquitin ligase;Ubiquitination;Undifferentiated;Viral;viral DNA;Viral Genome;Viral Pathogenesis;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Interplay between the cellular DNA damage response and the HPV life cycle

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Even though T cells are exposed to persistent antigen in chronic infections, cancer, autoimmunity and transplantation, we know very little about how T cell responses are maintained or how their function is modulated during chronic antigen stimulation. In this proposal, using a mouse model of chronic viral infection, we will study how co-stimulation and cellular interactions shape the maintenance and function of PD-1+ CD8 T cell responses. This understanding will be critical to understand fate decisions by chronically stimulated CD8 T cells and to improve immune interventions.

PI_NAMEs: KAMPHORST, ALICE OLIFFSON (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Address;Affect;Alleles;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;Autoimmunity;Biological;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;chemokine;Chemotactic Factors;Chimeric Proteins;Chronic;chronic infection;Coculture Techniques;Cytokine Receptors;Data;Dendritic Cells;Detection;Deterioration;differential expression;Disease;exhaust;experience;Exposure to;Gene Expression;Genetic Transcription;Hypersensitivity;Immune;immunological intervention;Immunotherapy;improved;in vivo;inducible gene expression;Interleukin-2;Intervention;Knowledge;Label;Lymphocytic choriomeningitis virus;Maintenance;Malignant Neoplasms;Memory;Molecular;mouse model;novel;pathogen;Pathology;Pathway interactions;Phase;Phenotype;Play;Positioning Attribute;Production;programmed cell death protein 1;programs;receptor;Resources;Role;self renewing cell;self-renewal;Shapes;Signal Transduction;Stromal Cells;T cell differentiation;T cell response;T cell transcription factor 1;T-Cell Activation;T-Lymphocyte;targeted treatment;TCF Transcription Factor;Testing;tool;Transplantation;tumor;Virus;Virus Diseases;XCL1 gene;XCR1 gene

PROJECT_TITLE: Determinants of differentiation and maintenance of PD-1+ CD8 T cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: GENETICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE  Transmission of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, requires that the organism survive aerosolization. This proposal exposes Mtb to air drying stress and tests the hypothesis that drying induces an adaptive metabolic response. The identification and inhibition of bacterially-encoded determinants of transmission would be a novel approach to halting the spread of disease.

PI_NAMEs: BROWN, CHRISTOPHER DAVID (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: 2019-nCoV;aerosolized;Aerosols;Air;Alveolus;Atmosphere;Bacillus;Base Excision Repairs;Biochemical Pathway;biological systems;Biology;Breathing;Carbon;career;Cause of Death;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Chemicals;clastogen;Clinical;Communicable Diseases;comparative;COVID-19;CRISPR interference;Data;Deposition;Desiccation;Detection;Development;Diagnostic;Diameter;Discipline;Disease;DNA Damage;Doctor of Philosophy;Dryness;Enzymes;Event;Exposure to;Gene Expression;Gene Silencing;Generations;global health;Goals;Grant;Health Professional;Health Services Accessibility;Household;Human body;Hydration status;Immunity;Immunologic Surveillance;Improve Access;Incidence;Individual;Infection;Influenza;Inhalation;insight;instructor;interest;international health organization;Investigation;Laboratories;Life Cycle Stages;Lower respiratory tract structure;Lung;Maps;medical schools;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Microbiology;Molecular;mortality;Mycobacterium tuberculosis;New York City;novel;novel strategies;Nucleotide Biosynthesis;Nucleotides;Organism;oxidative damage;Oxidative Stress;Oxidative Stress Induction;particle;pathogen;Pathway interactions;Population;Positioning Attribute;Predisposition;Process;Pseudomonas;Recovery;repaired;Research;Research Training;respiratory pathogen;response;Schools;Scientist;Secondary to;State Government;Streptococcus pneumoniae;Stress;success;Suspensions;Testing;Training;transmission blocking;transmission process;Transportation;treatment program;Trehalose;Tuberculosis;Vaccination;vaccine candidate;Virus;Water;Work

PROJECT_TITLE: The Transmission Biology of Mycobacterium Tuberculosis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Alcohol and other drug (AOD) abuse and violence in families are co-occurring risk factors that drive health disparities and mortality among Native Americans (NA), and thus, the long-term goal of this research is to promote health and wellness, while preventing and reducing AOD abuse and violence in NA families by testing an efficacious, sustainable, culturally-relevant and family-centered intervention for cross-national dissemination. Our central hypothesis is that the sustainable and community-based Weaving Healthy Families program will reduce and postpone AOD use, decrease and prevent violence in families, and promote resilience and wellness (including mental health) among NA adults and youth. The expected outcomes of the proposed research are an efficacious, culturally relevant, and sustainable community-based program to promote health and wellness among NA families that will address the factors that drive health disparities and promote individual, family, and community resilience.

PI_NAMEs: MCKINLEY, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Accidents;Address;adolescent alcohol and drug use;Adult;Affect;Alcohol abuse;alcohol and other drug;alcohol prevention;Alcohols;American Indian Women;anger management;Behavioral;Bison;Cardiovascular Diseases;Cause of Death;Cessation of life;Child Abuse and Neglect;Child Rearing;Choctaw;chronic liver disease;Cognition;cohort;Communities;community based participatory research;Community Health;community intervention;Consolidated Framework for Implementation Research;design;Diabetes Mellitus;Disparity;Drug abuse;drug misuse;Drug usage;efficacy testing;emotion regulation;Emotional;Environment;Evidence based program;experience;Family;Family member;Family Violence;Goals;Health;health disparity;Health Promotion;implementation intervention;Individual;innovation;Intervention;intimate partner violence;Knowledge;Liver Cirrhosis;Manuals;Measures;men;Mental Health;Methodology;Methods;Mississippi;Modeling;mortality;Native Americans;neglect;nutrition;Only Child;Outcome;Outcomes Research;Poisoning;Population;Premature Mortality;prevent;preventive intervention;Principal Investigator;Process;programs;promote resilience;protective factors;Psyche structure;Race;Recommendation;Research;Research Methodology;resilience;Risk Factors;scale up;social;Suicide;Testing;Translations;trial design;Tribes;Violence;violence prevention;Work;Youth

PROJECT_TITLE: Chukka Auchaffi’ Natana: The Weaving Healthy Families Program to Promote Wellness and Resilience and Prevent Alcohol and Other Drug Abuse and Violence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(51)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes

ORG_CITY: CINCINNATI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Continuous molecular monitoring has advanced from sensors tested in benchtop beakers, into numerous demonstrations of sensors inserted into animal jugulars for blood monitoring, and is now emerging into monitoring in the skin’s interstitial fluid which is the clinically successful approach used in wearable glucose monitors. However, a major knowledge gap for molecular monitoring centers on a simple yet impactful question: while glucose monitors have found hypodermal sensor placement to be most accurate, for other analytes and diseases what tissue layer in the skin, if any, will provide clinically accurate continuous monitoring? The objective of this R21 proposal is to fill this knowledge gap by creating and in-vivo testing the first ever multi-depth sensor array that enables simultaneous monitoring of analytes in the largely-acellular dermis vs. the adipocyte-rich hypodermis.

PI_NAMEs: HEIKENFELD, JASON  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Address;Adipocytes;Animals;aptamer;Biosensor;Blood;Blood capillaries;Brain natriuretic peptide;career;Chronic Disease;Clinical;clinical practice;comorbidity;Continuous Glucose Monitor;cost;density;Dermal;Dermis;Detection;Devices;diabetic;Diffusion;Dimensions;Disease;Disease Management;electric impedance;Electrodes;experience;first-in-human;Generations;Glucose;glucose monitor;glucose sensor;Goals;Healthcare;Heart Diseases;Human;human data;implanted sensor;in vivo evaluation;Industrialization;innovation;insight;Insulin;Intercellular Fluid;Interleukin-6;Investments;Knowledge;Letters;Longevity;Malignant Neoplasms;manufacture;Measurement;Measures;Molecular;Monitor;Nature;Needles;Outcome;Phenylalanine;Physiology;pro-brain natriuretic peptide (1-76);Rattus;receptor;Resistance;Science;sensor;sensor technology;Series;Skin;Subcutaneous Tissue;success;Technology;Testing;Tissues;tool;uptake;Vancomycin;wearable device;Work

PROJECT_TITLE: Answering an open and fundamentally important question: what skin-insertion depth is ideal for emerging continuous molecular monitors?

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This training grant will increase the number of scientists trained in reproductive biology, and prepared for a variety of career positions. This is important as it prepares scientists to participate in basic research, translational work on health and disease, education, entrepreneurship and public policy. Individuals with expertise in reproductive biology in combination with relevant career skills are of value to public health and this is one of the few research centers that stresses this combination in our training.

PI_NAMEs: MOENTER, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: career;Reproductive Biology;Training

PROJECT_TITLE: Career Training in Reproductive Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Integrated Biological Systems Training in Oncology (IBSTO) program, begun in 2008, prepares pre- doctoral students and post-doctoral fellows for careers in cancer research by comprehensive training in basic and translational oncology, communications, and career building. The IBSTO program takes place in a world- class cancer research environment with state-of–the-art facilities, experienced preceptors, extensive resources, and strong institutional support. The long-term mission of the IBSTO program is to advance inclusive excellence in cancer research and to enable and empower a diverse population of talented trainees to pursue diverse and impactful career paths that contribute to the amelioration of cancer.

PI_NAMEs: GAMA, VIVIAN ;TANSEY, WILLIAM PATRICK (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: biological systems;Oncology;Training

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EDWARDSVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE

PHR: Alzheimer’s disease (AD) is the most common type of dementia. Current medications have only modest clinical benefit and do not modify the course of the disease. The goal of this proof-of- concept program is to determine if sigma (σ1 and σ2) and dopamine (D2 and D3) receptor modulator AM73 has the capacity to mitigate cognitive decline in a mouse model of AD.

PI_NAMEs: WITT, KEN A (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Acetylcholinesterase;Address;Aducanumab;Affinity;Age;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amygdaloid structure;Amyloid beta-Protein;antagonist;Antibodies;association cortex;Attention;Behavior;Behavioral;Brain;Brain Edema;Brain region;brain tissue;Caregivers;cholinergic;Chronic;Clinical;Cognition;cost estimate;Dementia;Development;Disease;Disease Progression;Dopamine;Dopamine Receptor;Dose;drug development;drug discovery;Effectiveness;Evaluation;FDA approved;Female;Functional disorder;Gene Expression;Goals;Health Care Costs;Hippocampus;human old age (65+);Impaired cognition;Impairment;Individual;Injections;Life;male;Mediating;Memory;Methods;Midbrain structure;Mission;Motor;mouse model;mRNA Expression;Mus;N-Methyl-D-Aspartate Receptors;National Institute on Aging;Neurons;neuropsychiatric symptom;novel;Outcome;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Prevalence;programs;protein expression;receptor;reduce symptoms;Research Design;Research Training;response;senescence;side effect;sigma receptors;small molecule;Students;Symptoms;Therapeutic;therapeutic target;Work;Writing

PROJECT_TITLE: Dopamine and Sigma Receptor Mixed Modulators for the Treatment of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


NIH_SPENDING_CATS: Diabetes

PHR: PROJECT NARRATIVE Our program provides basic science trainees with the tools they need to develop a deep understanding of the molecular aspects of diabetes through strong laboratory-based research experiences, excellent mentorship, and an academic environment with a focus on multidisciplinary and comprehensive diabetes research. Training is a combination of immersion in specific research projects under the direction of experienced and accomplished senior researchers, formal education, and participation in a variety of other research-related educational activities. This training program fills a critical need to increase the number of future leaders in diabetes research.

PI_NAMEs: ARVAN, PETER ;MACDOUGALD, ORMOND A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Multidisciplinary Training Program in Basic Diabetes Research

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: PROVO

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

PHR: The proposed research is relevant to public health because it investigates new paradigms in protein crystallog- raphy and high-resolution structure determination. Development of new protein structure-determination tools will accelerate the study of molecular disease mechanisms, leading to more effective disease treatments. The pro- posed research is relevant to components of the NIH NIGMS’s mission that pertain to 1) understanding the principles, mechanisms, and processes that underlie living organisms and to 2) the development of fundamental methods and new technologies.

PI_NAMEs: MOODY, JAMES DANIEL (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;ANTXR2 gene;Biotechnology;cost;Cryoelectron Microscopy;Crystallization;Crystallography;Development;Disease;effective therapy;ETV6 gene;experimental study;flexibility;Goals;Health Care Costs;Human;human disease;innovation;interest;Investigation;Left;Length;leukemia;Ligand Binding;Malignant Neoplasms;Mediating;Methods;Mission;Molecular;Molecular Chaperones;Molecular Disease;National Institute of General Medical Sciences;new technology;novel strategies;Organism;Polymers;Process;programs;protein complex;protein function;protein structure;Proteins;Public Health;Research;Research Project Grants;Resolution;Resources;SAM Domain;Set protein;Side;Speed;Structure;success;symptom management;Techniques;Testing;Time;tool;United States National Institutes of Health;Variant;X-Ray Crystallography

PROJECT_TITLE: TELSAM polymers are powerful crystallization chaperones meriting continued investigation (Diversity Supplement)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: The research in this Center focuses on regulatory mechanisms in skin biology with a focus on epidermal stem cells, epidermal differentiation, skin repair, melanocytes, and skin vascular biology. The work has strong relevance to skin regeneration and regenerative medicine; to skin diseases with a disrupted barrier; and to skin aging and early stages of skin carcinogenesis. The work on melanocytes is relevant to a variety of pigmentation abnormalities and the work on skin vascular function is relevant to a number of vascular abnormalities.

PI_NAMEs: ANDERSEN, BOGI  (contact);GANESAN, ANAND K;LANDER, ARTHUR D

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Abnormal pigmentation;Area;Bioinformatics;Biology;Blood Vessels;Cells;collaborative approach;Communities;Creativeness;Data;data sharing;Development;Diagnosis;Discipline;Disease;Engineering;epidermal stem cell;experimental study;Faculty;Fertilization;Fostering;Funding;Genomics;Goals;Grant;Image;Imaging technology;Individual;innovation;interdisciplinary approach;interest;International;Knowledge;knowledge translation;Laboratories;large scale data;melanocyte;Methodology;Modeling;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new technology;Pathogenesis;Patients;Process;Productivity;programs;Publications;recruit;Regenerative Medicine;Reproducibility;Research;Research Personnel;Resources;Scheme;Science;Scientist;Services;Skin;Skin Aging;Skin Carcinogenesis;skin disorder;skin regeneration;Skin repair;Skin Tissue;symposium;Systems Biology;Technology;Tissue Engineering;tool;Training;Transcend;Translating;Translational Research;Translations;vascular abnormality;Work

PROJECT_TITLE: Skin Biology Resource-Based Center at UCI

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


PI_NAMEs: ANDERSEN, BOGI  (contact)

PROJECT_TERMS: Advisory Committees;Annual Reports;Area;Bioinformatics;Biology;Budgets;Collaborations;Communication;Communities;community engagement;complex data;Computer Analysis;Data;data dissemination;data integration;Dedications;Discipline;Disease;Education;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experimental study;Fertilization;Funding;Genomics;Grant;Image;improved;innovation;Institution;Interdisciplinary Study;Laboratories;Leadership;Logistics;meetings;member;Methods;Mission;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;operation;outreach;Performance;Productivity;programs;Publications;recruit;Reproducibility;Research;Research Personnel;Resources;Running;Scheme;Science;Scientist;Series;Services;Skin;Surveys;symposium;synergism;Systems Biology;technology development;Time;Training;Translational Research

PROJECT_TITLE: UCI P30 Skin Center Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SANDMEYER, SUZANNE  (contact)

PROJECT_TERMS: Age;analytical tool;appendage;assault;ATAC-seq;Awareness;Back;Bioinformatics;Biological;Biology;Cells;Charge;Chemicals;Chromatin;Collaborations;Communities;Computer software;Consultations;Custom;cytokine;Data;Data Analyses;data integration;Data Management Resources;data portal;Data Set;data sharing;Data Storage and Retrieval;deep learning;Development;Disease;Dissociation;DNA;Doctor of Philosophy;Documentation;Dryness;Educational workshop;Emerging Technologies;Ensure;Environment;experimental study;Fostering;Gene Expression;Genetic;Genomics;Goals;Immune system;improved;innovation;insight;large scale data;Maps;Measurement;Metabolism;metabolomics;Molecular;molecular dynamics;Multiomic Data;multiple omics;Names;Network-based;Pathway Analysis;Play;preservation;programs;Proteins;Protocols documentation;Publications;Reagent;repaired;Research;Research Personnel;Resolution;Resources;Role;Signal Transduction;single cell sequencing;Skin;skin organogenesis;Skin Tissue;Specificity;Standardization;Technology;technology development;tissue processing;tissue regeneration;Tissues;tool;Training;training opportunity;transcriptomics;user-friendly;Variant;Visualization;Visualization software;wound healing

PROJECT_TITLE: UCI P30 Skin Center Multi-Omics Core


PI_NAMEs: GRATTON, ENRICO  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Biology;Blood flow;burn wound;cell motility;Cells;Center Core Grants;Clinical;Collaborations;Communities;Data;data acquisition;Deposition;design;Development;diffuse optical spectroscopy and imaging;Disease;Dyes;Educational workshop;Engineering;Ensure;Environment;Epidermis;experimental study;Fluorescence;fluorescence lifetime imaging;Fostering;Gene Expression;Gene Expression Profile;Genes;genetic manipulation;Genotype;Goals;Grant;Heterogeneity;Homeostasis;Human;Image;Imaging Device;imaging facilities;imaging modality;imaging platform;Imaging Techniques;Imaging technology;In Vitro;in vivo;insight;instrument;Knowledge;Label;Laboratories;laboratory experiment;Laser Speckle Imaging;lectures;Measures;meetings;member;Metabolic;Methods;Microscope;microscopic imaging;Modeling;Molecular;Molecular Probes;Multiphoton Fluorescence Microscopy;multiphoton microscopy;Mus;novel;novel strategies;Organoids;Paper;peer;Peer Review;Phenotype;Physiology;prototype;Publications;Publishing;Reproducibility;Research;Research Personnel;Resolution;Resources;response;Role;Services;Signal Transduction;single cell technology;Site;Skin;skin disorder;Spatial Distribution;Spatial Frequency Domain Imaging;spatial relationship;success;Surveys;Systems Biology;Techniques;Technology;technology development;Testing;Thick;Time;Tissue Engineering;Tissue imaging;Tissue Model;tissue oxygenation;Tissues;tool;Training;Travel;Visit;Visualization;Work;wound healing

PROJECT_TITLE: UCI P30 Skin Center Imaging-Engineering Core


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LANDER, ARTHUR D (contact)

PROJECT_TERMS: Appointment;Area;Big Data;Biological;biological research;Biology;Biomedical Research;career development;Chemistry;Clinic;Collaborations;Collection;Communities;complex biological systems;complex data;computer science;Consultations;Data;Data Analyses;data integration;Data Science;Data Set;Dedications;Disease;Education;Education and Outreach;Educational process of instructing;Educational workshop;Engineering;Ensure;experience;Experimental Designs;Face;Faculty;Fertilization;Fostering;Foundations;Generations;Goals;Grant;high dimensionality;Image;improved;Individual;Infrastructure;innovation;insight;Laboratories;laboratory experiment;Literature;mathematical methods;Mathematics;meetings;member;Modeling;multidimensional data;multiple omics;novel strategies;Output;outreach;Physics;Postdoctoral Fellow;Process;Productivity;Publishing;Reproducibility;Research;research and development;Research Personnel;Resources;Rotation;Science;Scientist;Series;Services;skill acquisition;Skin;skin disorder;System;Systems Biology;Techniques;Time;tool;Training;Visit;Work

PROJECT_TITLE: UCI P30 Skin Center Systems Biology Core


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Women's Health Research

ORG_NAME: HERBERT H. LEHMAN COLLEGE

ORG_STATE: NY

PHR: Project Narrative This proposal is relevant to public health because it will delineate the mechanism by which selective mRNA translation regulated metabolic reprogramming in Triple Negative Breast Cancer. Successful completion of the proposed aims will help to identify metabolites that could ultimately be targeted to improve clinical outcomes in advanced breast cancer; a clear emphasis of the NIH mission.

PI_NAMEs: DE LA PARRA, COLUMBA  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 4T1;advanced breast cancer;Advanced Malignant Neoplasm;Affect;Apoptotic;Attenuated;Biopsy;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Carcinoma;Calcium;cancer cell;cancer invasiveness;Cancer Patient;Cause of Death;Cells;Cellular Metabolic Process;Clinical;Data;Databases;Disseminated Malignant Neoplasm;glucose metabolism;Glycolysis;Goals;HK2 gene;Homeostasis;Human;Hypoxia;improved;in vivo;Invaded;Link;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolism;metabolomics;Metastatic Neoplasm to the Lung;Mission;Molecular;molecular marker;mouse model;mRNA Expression;mRNA Translation;Mus;Neoplasm Metastasis;neoplastic cell;novel;nutrient deprivation;Oncogenic;Outcome;Oxidative Stress;Pathway interactions;Patients;physiologic stressor;Physiological;Play;Primary Neoplasm;Prognosis;Protein Biosynthesis;Public Health;Regulation;Research;Resistance;response;Role;small hairpin RNA;Stress;The Cancer Genome Atlas;therapy resistant;tool;trait;Translating;Translation Initiation;Translational Regulation;Translations;triple-negative invasive breast carcinoma;tumor;tumor metabolism;United States National Institutes of Health

PROJECT_TITLE: The role of an alternate mechanism of translation initiation in TNBC Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative Lyme disease, caused by bacteria Borrelia burgdorferi sensu lato, is the most common arthropod-transmitted disease in the U.S. The investigations proposed in this study will expand our understanding on the mechanisms of wild birds as reservoirs to maintain Lyme disease bacteria in nature. Such information can facilitate the understanding of vector-borne enzootic cycle, fostering the development of public health approaches for the intervention of B. burgdorferi spread in nature, reducing the risks of human exposure to Lyme disease causing bacteria

PI_NAMEs: LIN, YI-PIN  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Adopted;American;Animals;Antibodies;Antibody Response;arthropod-borne;Bacteria;Birds;Blood;Borrelia burgdorferi;Borrelia burgdorferi Group;Cell Culture Techniques;Communicable Diseases;Competence;Complement;Cytolysis;Data;defined contribution;Development;Disease;Disease Outbreaks;disease transmission;Environment;enzootic;exposed human population;Exposure to;Failure;Fostering;Genes;Genotype;Goals;Human;Immune;Immune response;Immune Tolerance;Immunologics;immunoregulation;In Vitro;in vivo;Infection;Inflammatory;Interferon Type II;Intervention;Investigation;Ixodes;Knowledge;Laboratories;Laboratory Finding;Laboratory mice;Larva;Lyme Disease;Maintenance;Mediating;Modeling;Mus;Nature;Organ;OspC protein;Outcome;pathogen;Pathway interactions;Peripheral Blood Mononuclear Cell;permissiveness;Peromyscus;prevent;Prevention;Public Health;public health intervention;response;Risk;Robin bird;Rodent;Role;Skin;Surface;Symptoms;Testing;tick bite;TNF gene;transmission process;Variant;vector-borne;Vector-transmitted infectious disease;White-Footed Mouse;wild bird;Zoonoses

PROJECT_TITLE: Immunomodulatory mechanisms of wild bird reservoir hosts that facilitate persistence of Lyme disease bacteria

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE The Case Medical Student Summer Research Program in Aging and Alzheimer’s Disease (MSSRPA) at Case Western Reserve University School of Medicine (CWRU SOM) will attract medical students to careers as physician-scientists by providing students with a 12-week research experience during the summer between their first and second year of medical school under the mentorship of highly qualified and motivated faculty mentors in aging and Alzheimer’s disease. The 19 mentors are well-funded, garnering $14M per year, (average $738,000 per investigator) and currently train 25 medical students in their labs, in addition to PhD students and postdoctoral fellows. The academic institutional environment at CWRU SOM is ideal to support this program.

PI_NAMEs: DAVIS, PAMELA B (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Advisory Committees;Aging;Alzheimer's Disease;Area;career;career development;Clinic;Collaborations;community based research;Educational Curriculum;Eligibility Determination;Enrollment;Environment;Evaluation;experience;Feedback;Funding;Goals;Grant;Group Meetings;Hospitals;innovation;Institution;Instruction;Investigation;Joints;lectures;Medical center;Medical Education;medical schools;Medical Students;Mentors;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;Physicians;Prions;Process;Program Evaluation;programs;Publications;Qualifying;Records;Reproducibility;Request for Applications;Research;Research Personnel;Research Project Grants;Research Support;response;responsible research conduct;Scientist;Students;summer research;Surveys;Training;Training Programs;Training Support;Underrepresented Populations;Underrepresented Students;Universities;University Hospitals;Writing

PROJECT_TITLE: Medical Student Summer Research Program in Aging and Alzheimer's disease (MSSRPA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE In the United States, the number of deaths resulting from opioid over dose is rapidly increasing and has reached epidemic proportions in recent years. The available FDA-approved treatment options for opioid over doses and withdrawal symptoms are limited and inadequate. Here we want to test whether TFEB, a master regulator of autophagy could reduce opioid-induced withdrawal symptoms as well as tolerance, dependence and respiratory depression by enhancing synaptic plasticity based on solid evidence that TFEB physically interacts with opioid receptors.

PI_NAMEs: LAKSHMANA, MADEPALLI KRISHNAPPA (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;Acute Lung Injury;Address;Adoption;Adverse effects;Affect;Aging;Alcohols;Analgesics;Autophagocytosis;Body Weight decreased;Brain;brain reward regions;Cannabinoids;Catabolism;Cell Line;Cell Nucleus;cell type;Cells;Cessation of life;Chronic;chronic pain management;Co-Immunoprecipitations;Cocaine;conditioned place preference;Corpus striatum structure;COVID-19 pandemic;Data;density;Dependence;depressive symptoms;desensitization;Development;dopaminergic neuron;Dose;Drug Addiction;drug discovery;Drug usage;Energy Metabolism;Epidemic;Excretory function;Exocytosis;experience;Exposure to;Family;FDA approved;Fentanyl;frontal lobe;Future;G-Protein-Coupled Receptors;gene network;Genes;Genetic;Genetic Transcription;Genitalia;GTP-Binding Proteins;Health;Heritability;Heroin;Hippocampus;Human;Immune response;immunoregulation;In Vitro;in vivo;Inflammation;knock-down;Knockout Mice;Lipids;Lysosomes;Measures;Mediating;Membrane;Methadone;Methods;Mitochondria;Molecular;Morphine;mu opioid receptors;Mus;Naloxone;National Institute of Drug Abuse;Nerve Degeneration;nerve injury;Nervous System Disorder;Neuronal Plasticity;Neurons;neuroprotection;Nicotine;Nociception;novel;Nuclear Translocation;Opiate Addiction;opiate tolerance;Opioid;Opioid agonist;opioid epidemic;opioid overdose;Opioid Receptor;opioid therapy;opioid use;opioid use disorder;opioid withdrawal;Organelles;overdose death;overexpression;Pain;pain relief;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Play;Positioning Attribute;Prefrontal Cortex;Prevalence;prevent;promoter;Property;protein expression;Receptor Signaling;Receptor-Interacting Protein;Recycling;Reporting;Research Design;Respiratory Signs and Symptoms;Rewards;Role;senescence;Small Interfering RNA;small molecule;Solid;Spinal Cord;stable cell line;Structure;Structure of parenchyma of lung;Substance Use Disorder;Substantia nigra structure;Synapses;Synaptic plasticity;synthetic opioid;Tail;Testing;therapeutic opioid;Time;Transcription Coactivator;transcription factor;transgene expression;Transgenic Mice;Twin Multiple Birth;United States;Ventilatory Depression;Ventral Tegmental Area;Vertebral column;Wild Type Mouse;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: The potential benefits of autophagy activator TFEB in opioid use disorder in mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 DPI-7 (03)]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  The actin cytoskeleton has been historically studied for its functional role in the cytoplasm, although its existence in the nucleus has been identified over 50 years ago. In this proposal, we aim to study the elusive nuclear actin in multiple fields that it has never been explored before: understanding its function and consequences of its breakdown during aging, investigating how nuclear actin regulation changes during stress, and investigating the impact of nuclear actin on DNA repair and transcriptional regulation. This highly innovative proposal aims to tackle a very young and burgeoning field by developing cutting edge genetics, microscopy, biochemical, and computational tools to answer questions that were previously unanswerable.

PI_NAMEs: HIGUCHI-SANABRIA, RYO  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Actins;age-related disease;Aging;aging process;biochemical tools;Biology;black hole;Caenorhabditis elegans;Cell Nucleus;Cell Physiology;cell type;Cells;Clinical;Collaborations;computerized tools;Cytoplasm;Cytoskeleton;Defect;Deterioration;Disease;DNA;DNA Damage;DNA Repair;Dyes;Equilibrium;experimental study;F-Actin;Failure;fitness;Functional disorder;Genetic;Genetic Models;Genetic Transcription;Genomic Instability;Goals;Grant;Health;Homeostasis;Image;innovation;Label;Linear Models;Literature;Longevity;loss of function;Maps;Methods;Microfilaments;Microscopy;model organism;Modeling;monomer;Motility;Movement;Mutate;novel;Nuclear;Nucleic Acids;Physiological;Play;Polymers;Premature aging syndrome;preservation;prevent;Process;Proteins;proteostasis;Quality Control;recruit;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;response;RNA;Rod;Role;Site;Stains;Standardization;Stress;Structure;System;Techniques;Technology;Testing;tool;Transcriptional Regulation;Utrophin;Variant;Vision;Visualization;Western Blotting

PROJECT_TITLE: When actin's not actin like actin: Nuclear actin impacts transcription and aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: PROJECT NARRATIVE This highly interdisciplinary program has a successful 50-year history of training scientists for careers in molecular toxicology and directly environmental health. Previous trainees have gone on to successful and productive careers including in academia, industry, and government institutes. Trainees specialize in specific subdisciplines of basic and translational research while being exposed to a far wider range of approaches and research areas through the diverse faculty, along with career-development support.

PI_NAMEs: GUENGERICH, F PETER;HARRISON, FIONA EDITH (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Training Program in Environmental Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Musculoskeletal diseases are among the most prevalent health conditions and lead to chronic pain, disability, psychological distress and decreased quality of life. Thus, research into the prevention and treatment of these disorders is critically needed. The overall goal of the Center for Musculoskeletal Research is to foster interdisciplinary and collaborative work that leads to a deeper understanding of musculoskeletal science, in a way promotes new approaches to the diagnosis and treatment of musculoskeletal diseases.

PI_NAMEs: BOUXSEIN, MARY L;DEMAY, MARIE  (contact);DIVIETI PAJEVIC, PAOLA

PROJECT_TERMS: Address;Advisory Committees;Affect;Applications Grants;Area;Arthritis;Biology;Biomechanics;bone;bone cell;Boston;career;Cells;Cellular biology;Charge;chronic pain;clinical investigation;Clinical Investigator;clinical phenotype;Collaborations;Communication;Communities;community center;Core Facility;Data;Developmental Biology;Diagnosis;directed differentiation;disability;Discipline;Disease;Education;Educational workshop;Ensure;Equity;Ethnic Origin;Evaluation;experience;Experimental Designs;Feedback;Fostering;Funding;Funding Opportunities;Gender;Gender Identity;Genetic;Genetic Transcription;Goals;Grant;Health;Health Care Costs;high school;Histologic;Histology;Human;human old age (65+);human tissue;image translation;Individual;induced pluripotent stem cell;innovation;Institution;interest;Investigation;Investments;Joints;Lead;Leadership;lectures;Life;member;Mentors;Methodology;Methods;Mission;Molecular Analysis;Mus;Muscle;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;New England;novel;novel strategies;outreach;outreach program;pandemic disease;Phenotype;Population;posters;Prevention;Productivity;programs;Protocols documentation;psychological distress;Publications;Quality of life;Race;Radiology Specialty;Reporting;repository;Research;Research Personnel;Resources;response;Science;Scientist;Series;Services;Sex Orientation;single-cell RNA sequencing;skeletal;Skeleton;STEM research;success;Surveys;symposium;Tendon structure;Time;Tissue Differentiation;Tissue Engineering;tool;transcriptomics;translational scientist;Underrepresented Populations;university student;web site;Work

PROJECT_TITLE: Center for Musculoskeletal Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 FY (M1)]


PI_NAMEs: DEMAY, MARIE  (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Applications Grants;Back;career;career development;Collaborations;Collection;Communication;Communities;community building;community center;Community Outreach;Core Facility;cost;Data;design;Diagnosis;Discipline;Education;Educational workshop;effectiveness evaluation;Ensure;equity, diversity, and inclusion;Evaluation;experience;Feedback;Fees;Fostering;Funding;Funding Opportunities;Goals;Grant;Human Resources;innovation;innovative technologies;Institution;Investigation;Journals;Leadership;lectures;meetings;member;Mentors;Mentorship;Mission;Musculoskeletal;Musculoskeletal Diseases;novel strategies;operation;outreach;Philosophy;programs;Publishing;Quality Control;Research;Research Personnel;Research Project Grants;Resources;response;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;Series;Services;summer student;Surveys;symposium;Techniques;Training;Voice;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging

PI_NAMEs: BOUXSEIN, MARY L (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;Animal Model;Area;biobank;Biology;biomechanical test;bone;Boston;Cell Physiology;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Collaborations;Communities;Consultations;Core Facility;cost;cost effective;design;Disabling condition;Education;Educational process of instructing;Educational workshop;Environment;Equity;experience;Extracellular Matrix;Fostering;Funding;Genotype;Goals;Health Services Accessibility;Histology;Human;human old age (65+);image archival system;image translation;imaging approach;improved;in vivo;in vivo imaging;Individual;innovation;Institution;Investigation;Laboratories;Lead;Leadership;Magnetic Resonance Imaging;Medical;member;Mentors;Metabolism;Methodology;Molecular;Molecular Analysis;Morphology;multidisciplinary;Mus;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;Musculoskeletal System;New England;Patient-Focused Outcomes;Pediatric Hospitals;Performance;Peripheral;Persons;Phenotype;Productivity;Quality Control;Recommendation;Research;Research Personnel;Research Support;Resolution;Resource Sharing;Sampling;Scientific Advances and Accomplishments;Series;Services;skeletal;skeletal disorder;soft tissue;Structure;success;Techniques;Technology;testing services;tomography;Training;Training and Education;Translating;Translational Research;Translations;Update;Work;X-Ray Computed Tomography

PROJECT_TITLE: Translational Imaging and Phenotyping Core