NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Solid tumors are a mixture of cell types that support tumor growth and prevent the immune system from killing cancer cells. We’ve designed a method to reprogram immune cells to target not only cancer cells but also eliminate support cells. We will optimize this therapy through rigorous preclinical testing and then test it in a clinical trial in patients with pancreatic cancer.

PI_NAMEs: MAUS, MARCELA VALDERRAMA (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Achievement;Address;advanced disease;advanced pancreatic cancer;adverse event monitoring;Antibodies;antigen binding;Antigen Targeting;Antigens;antitumor effect;Binding;Biological Assay;Biology;Bispecific Antibodies;Blood;Bone Marrow;cancer cell;CAR T cell therapy;CD3 Antigens;cell killing;Cell Physiology;Cell Therapy;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;combinatorial;Correlative Study;cytokine;Data;density;design;detection assay;disease prognosis;Dose;Drug Combinations;Drug Targeting;Effectiveness;Engineering;Engraftment;Extracellular Matrix;fibroblast-activating factor;Fibroblasts;Genetic Markers;Hematologic Neoplasms;Immune;Immune response;Immune system;improved;In Vitro;in vivo;Infiltration;Infusion procedures;inhibitor;Injections;Intravenous;Intravenous infusion procedures;Knowledge;Lentivirus Vector;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;mesothelin;Methods;Modeling;Monitor;mouse model;Neoplasm Metastasis;neoplastic cell;neurotoxicity;Normal Cell;novel;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patient Monitoring;Patient-Focused Outcomes;Patients;PD-1 inhibitors;pembrolizumab;Peripheral;peripheral blood;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Phenotype;Plasmids;pre-clinical;Pre-Clinical Model;Preclinical Testing;prevent;programmed cell death protein 1;programs;protein expression;Protocols documentation;Recommendation;Resistance;response;Role;Route;Safety;Solid;Solid Neoplasm;Supporting Cell;synergism;T cell infiltration;T-Lymphocyte;Testing;Time;Tissues;Toxic effect;treatment optimization;trial design;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Suppression;Work

PROJECT_TITLE: CAR T cells targeting mesothelin and secreting bispecific antibodies targeting fibroblasts in pancreatic cancer


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Neurodegenerative diseases, such as Alzheimer’s disease, are characterized by the accumulation of harmful protein aggregates due to impaired clearance of these toxic particles. Understanding the molecular mechanisms of aging that contribute to disease onset and prognosis is key to developing targeted therapies for future use in patients affected by these diseases.

PI_NAMEs: LANE-DONOVAN, COURTNEY E (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Academic skills;Acidity;Affect;Age;age effect;age related;age related changes;age related neurodegeneration;aged;Aging;aging brain;aging mechanism;aging related;aging related disease;aging reversal;Alkalinization;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapy;Area;Astrocytes;Automobile Driving;Autophagocytosis;Brain;brain cell;Brain region;brain tissue;Caenorhabditis elegans;California;career;career development;Cathepsins;Cell Separation;cell type;Cells;Cellular biology;Characteristics;Clinical;Data;Development;Disease;disease prognosis;Disease susceptibility;DNA Sequence Alteration;effective therapy;experience;experimental study;Functional disorder;Future;Genes;genetic risk factor;Genetic Transcription;Goals;Grant;Human;Image;Immunohistochemistry;Impairment;in vitro activity;in vivo;Individual;Invertebrates;J20 mouse;Knowledge;Libraries;Lysosomes;Mammals;Memory;Mentors;Microglia;misfolded protein;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurology;Neurons;neuroprotection;new therapeutic target;novel;Onset of illness;Outcome;particle;Pathogenesis;Pathology;Patients;Peptide Hydrolases;Phenotype;Physicians;Predisposition;pro-aging;Program Development;protein aggregation;protein degradation;protein expression;Proteins;proteostasis;proteostasis loss;Psychiatry;regional difference;Reporter;Reporting;Research;Research Personnel;Role;Running;Saccharomyces cerevisiae;San Francisco;Scientist;sensor;skills;spatiotemporal;Stress;targeted treatment;Testing;Therapeutic;therapeutic development;Tissue Sample;Tissues;tool;Training;transcriptomics;Universities;Variant;Work;Yeasts

PROJECT_TITLE: Illuminating Lysosomal Dysfunction in Aging and Alzheimer's Disease (AD)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Telehealth;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: We aim to validate a comprehensive remote neuropsychological toolbox, which would enable researchers and clinicians to accurately and reliably assess cognition and function of older adults who are at risk of Alzheimer’s disease and other dementia (ADRD) when in-person assessments are not feasible or safe. Remote assessment will facilitate more frequent evaluations at lower cost, potentially improving sensitivity, reliability, and validity of cognitive assessment for observational studies, clinical trials and clinical practice. The diverse older adult cohort afforded through the Bronx community will advance our understanding of disparities in ADRD, which will have implications for intervention and disease monitoring in future studies.

PI_NAMEs: EZZATI, ALI ;LIPTON, RICHARD B. (contact);RABIN, LAURA A.

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acoustics;Address;Advocate;Agreement;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Biological Markers;Black race;blood-based biomarker;Calibration;Caring;Classification;Clinical;clinical practice;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive performance;cognitive testing;cohort;Cohort Studies;Communities;computerized;cost;COVID-19 pandemic;Data;Data Collection;Data Set;Dementia;design;Development;Devices;digital;Digital biomarker;Disease;Disparity;Electronic Health Record;Ensure;ethnic diversity;Ethnic Origin;Ethnic Population;Evaluation;follow-up;Frail Elderly;functional decline;functional status;Future;Glial Fibrillary Acidic Protein;Goals;Grant;Healthcare Systems;Hispanic;human old age (65+);Impaired cognition;improved;Individual;Intervention;low socioeconomic status;Measures;Methods;mild cognitive impairment;Modality;Monitor;neurofilament;Neuropsychological Tests;Neuropsychology;Not Hispanic or Latino;novel;Observational Study;older adult;open source;pandemic disease;Participant;Pathologic;Pathology;Patient Care;Pattern;Performance;Persons;Population Heterogeneity;pre-clinical;Property;Psychometrics;Race;racial diversity;racial population;Randomized;recruit;remote administration;remote assessment;remote grading;remote visit;Research;Research Personnel;Risk;Safety;Sampling;Semantics;Services;sex;Speech;Subgroup;Tablets;Telephone;Testing;Time;Underserved Population;Vaccination;Validation;Videoconferencing;Visit

PROJECT_TITLE: Validation of the Remote Cognitive Aging and Alzheimer’s Disease REsearch (R-CARE) Toolbox for Diverse Populations

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research will provide initial validation of multiparametric quantitative imaging and the derived surrogate to assess the liver-pancreas axis of diabetes progression in nonalcoholic fatty liver disease. This proposal will further advance magnetic resonance elastography as a practical imaging tool for qualitatively and quantitatively monitoring pathophysiological states of abdominal organs/glands as it becomes increasingly useful for detecting or characterizing important diffuse disease processes of steatosis, inflammation, and fibrosis, providing capabilities unavailable with other imaging techniques. Imaging-based risk prediction of diabetes development may allow earlier detection, diagnosis, and treatment, ultimately improving health outcomes for the general population.

PI_NAMEs: YIN, MENG  (contact)

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: 3-Dimensional;Abdomen;Adipose tissue;Adult;Advanced Development;Affect;Agreement;Algorithms;American;Assessment tool;Benchmarking;Biological Markers;Body Weight decreased;Breathing;Caloric Restriction;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Data;clinical practice;comorbidity;Coupled;Cross-Sectional Studies;data acquisition;Development;Diabetes Mellitus;Diabetes prevention;diabetic;Diagnosis;Diffuse;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;elastography;end stage liver disease;Enzymes;Epigenetic Process;Fatty acid glycerol esters;Fatty Liver;Fibrosis;follow-up;Frequencies;General Population;Gland;Glucagon;Glucose;Goals;Guidelines;Health;healthy volunteer;Hepatic;Hepatic Tissue;High Prevalence;Hormones;Hybrids;Hyperglycemia;Image;image reconstruction;imaging biomarker;Imaging Device;Imaging Techniques;Impairment;improved;Inflammation;Inflammatory;insight;Insulin;insulin secretion;insulin sensitivity;Intervention;Islets of Langerhans;Knowledge;Laboratories;Life Style;Link;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;Metabolic;Metabolic Diseases;Metabolic Pathway;Methods;Modeling;Modification;Modulus;Monitor;Motion;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;obese person;Obesity;Oral;Organ;Outcome;Pancreas;Pancreatic Diseases;Pancreatitis;Patients;Pharmaceutical Preparations;precision medicine;Prediabetes syndrome;Process;programs;progression risk;Protocols documentation;quantitative imaging;Radial;reconstruction;recruit;Relaxation;Research;Resolution;Risk;Risk Assessment;Risk Factors;risk prediction;Scanning;statistics;Steatohepatitis;Structure;success;Techniques;Technology;technology development;temporal measurement;Testing;Therapeutic Intervention;Time;Tissues;Training;Translations;treatment effect;Validation;vector;Water;Weight;Withdrawal;Work

PROJECT_TITLE: Quantitative characterization of the liver-pancreas axis in diabetes via multiparametric magnetic resonance elastography

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Age-related macular degeneration is a common devastating disease that can lead to blindness. We recently found that loss of blood vessels appears to play an important role in the earliest stages of macular degeneration. The goal of this research program is to pursue new treatments for AMD by determining how blood vessel cells respond to immune injury, what factors make blood vessel cells susceptible to damage, and to develop methods to replace damaged blood vessels using stem cells.

PI_NAMEs: MULLINS, ROBERT FOSTER (contact);TUCKER, BUDD A

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Affect;Age related macular degeneration;Aging;Antibodies;Autologous;Bar Codes;Biochemical;Blindness;blood damage;Blood Vessels;Bruch's basal membrane structure;Cell Aging;Cell Death;cell injury;Cells;cellular pathology;Choroid;Clinical;cohort;Complement;Complement Factor H;Complement Membrane Attack Complex;complement pathway;density;Deposition;design;Disease;Disease Progression;Drusen;Endothelial Cells;Endothelium;Eye;Functional disorder;Genotype;Goals;Health;Hemorrhage;high risk;Histologic;Human;Imaging Techniques;Immune;Individual;induced pluripotent stem cell;Injury;Longevity;macula;Macular degeneration;Methods;Mitochondria;Modeling;Molecular;multiple omics;Organ Culture Techniques;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Photoreceptors;Play;Predisposition;prevent;programs;Public Health;Rattus;Research;response;risk variant;Role;stem cells;Structure of retinal pigment epithelium;success;Transplantation;vascular bed

PROJECT_TITLE: Choriocapillaris Protection and Replacement in AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: COLUMBIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This proposal aims to understand and control dental pulp stem cell (DPSC) polarization and differentiation, and regenerate functional tubular dentin using DPSCs. Completion of this project will significantly facilitate the development of innovative biomaterials for regenerative endodontics, therefore, improve the health of hundreds of millions of people in US.

PI_NAMEs: LIU, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Ablation;Adult;Affect;Age Years;Architecture;Biochemical;Biocompatible Materials;Biological Process;Biology;Biomedical Engineering;Biomimetics;Biophysics;Bone Regeneration;Cells;Chronic Disease;Clinical;conditional knockout;Data;Dental;Dental caries;Dental Pulp;dental structure;Dentin;design;Development;Endodontics;Environment;Extracellular Matrix;Functional Regeneration;Grant;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Health;Human;improved;In Vitro;in vivo;innovation;Island;Knowledge;Lasers;manufacturing technology;Microdissection;Modeling;Mus;nano;nanofabrication;nanofiber;Natural regeneration;Neurons;Odontoblasts;Odontogenesis;Outcomes Research;Pathway interactions;Peptide Initiation Factors;Persons;polarized cell;Process;receptor;regenerative;Regulation;Research;scaffold;Signal Transduction;stem cells;Structure;Techniques;Technology;Testing;tissue regeneration;Tissues;tool;Tooth root structure;transcriptome;transcriptome sequencing;translational applications;Tubular formation;United States;Work

PROJECT_TITLE: Regulation of Dental Pulp Stem Cell Polarization for Tubular Dentin Regeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative This R01 proposal will examine the effects of IMPACT on racial disparities in hospice care in NH residents with ADRD, and to characterize subgroups that are most likely to experience inadequate hospice care. The primary hypothesis is that racial disparities in EOL care increased persistently after IMPACT was implemented.

PI_NAMEs: YE, LICHUAN ;ZHANG, NING  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: acute care;Advocacy;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Assessment tool;beneficiary;Black race;care providers;Caring;Categories;Cessation of life;Characteristics;Classification;Clinical;Communities;Complex;curative treatments;Data;Data Set;Data Sources;Dementia;Disparity;Emergency department visit;end of life;end of life care;Enteral Feeding;Equity;experience;federal policy;Goals;Health;health equity;health equity promotion;high risk;high risk population;Hospice Care;hospice environment;Hospice Programs;hospice utilization;Hospitalization;improved;Individual;insight;Insurance Carriers;Intensive Care Units;Interruption;Intervention;IV Fluid;Length;Life;Location;Machine Learning;Measures;Medicare;Methods;multiple chronic conditions;Nursing Homes;older adult;pain reduction;Pathway Analysis;Patient Care;Patient Selection;Patients;Pharmaceutical Preparations;Phenotype;Police;Policies;Policy Maker;Prognosis;Provider;Quality of life;Race;racial disparity;Reporting;Risk;Series;Subgroup;Syndrome;Time;Vulnerable Populations

PROJECT_TITLE: Impact of federal policies on disparities at the end of life care among nursing home residents with Alzheimer's diseases or related dementia


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cancers cannot initiate or progress if their subcellular components are unable to overcome the stresses that accompany uncontrolled proliferation and growth. This Center seeks a predictive understanding of subcellular adaptations that must take place to accommodate and subvert the stresses that naturally occur in response to cancer-causing genetic alterations. Successful models of such adaptations will lead to secondary inferences about where cancer cells become vulnerable as a result of their internal adaptations.

PI_NAMEs: JANES, KEVIN A (contact);LAZZARA, MATTHEW J

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adopted;Aneuploidy;Automobile Driving;Cancer Biology;cancer cell;Cancer Model;cancer type;career;Cell Culture Techniques;Cell membrane;cell type;Cells;Cellular biology;Charge;Chromosomes;Chronic;Clinical and Translational Science Awards;clinical practice;Collaborations;Colorectal Cancer;Complex;cost;Couples;Cultured Cells;Data;Decision Making;Dedications;Defect;Disease;Ecosystem;Education;Elements;Epidermal Growth Factor Receptor;Eukaryota;experimental study;Faculty;feature detection;feature extraction;Fostering;Genetically Engineered Mouse;Genomics;Glioblastoma;Goals;Growth;Image;image registration;Immunofluorescence Immunologic;Indirect Immunofluorescence;innovation;Institution;interoperability;Joints;KRAS2 gene;Lead;Leadership;learning strategy;Length;Lesion;Life;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mentorship;Metabolic;Metaphase;Metastatic Neoplasm to the Liver;Mitochondria;mitochondrial membrane;Mitotic;Modeling;multidisciplinary;mutant;Mutation;NCI Center for Cancer Research;Neoplasm Metastasis;Oncogene Activation;Oncogenes;Oncogenic;Organelles;outreach;Pathway interactions;Phase;Phenotype;Pilot Projects;Play;Positioning Attribute;Primary Neoplasm;Process;programs;Proliferating;Records;Recurrence;repaired;Research;Research Personnel;Research Project Grants;residence;Resolution;Resource Sharing;Resources;response;Rest;Role;Secondary to;Signal Transduction;Site Visit;Standardization;Stress;Structure;success;summer research;System;Systems Analysis;Systems Biology;Testing;Training;transcription factor;tumor;tumorigenesis;undergraduate research experience;Universities;Virginia;Vision

PROJECT_TITLE: Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JANES, KEVIN A (contact)

PROJECT_TERMS: Administrative Supplement;Administrator;anti-cancer research;anti-racism;Awareness;Biological Models;career;Charge;Communication;Communities;Complement;cost;Coupled;Couples;Data;data management;data modeling;Data Set;data sharing;Decision Making;Deposition;disadvantaged background;Ensure;Evaluation;Event;expectation;experience;Face;Faculty;Funding Mechanisms;Future;Goals;Health system;Hearing;improved;Individual;Institutionalization;Internet;Lead;Leadership;Logistics;Maintenance;Malignant Neoplasms;marginalization;marginalized population;meetings;member;Mentors;Mentorship;Mission;Monitor;Names;next generation;Organelles;organizational structure;Output;outreach;Ownership;Pilot Projects;Postdoctoral Fellow;Productivity;programs;racism;recruit;repository;Request for Applications;Research;Research Activity;Research Personnel;Resources;Role;Schedule;Scientist;Site Visit;Stress;success;synergism;System;Systems Analysis;Systems Biology;Time;timeline;Training;U-Series Cooperative Agreements;United States National Institutes of Health;University of Virginia Cancer Center;virtual;Vision;Voice;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetics;Women's Health Research

PI_NAMEs: STUKENBERG, P. TODD  (contact)

PROJECT_TERMS: Alleles;Aneuploid Cells;Aneuploidy;Animals;aurora B kinase;Behavior;Binding;Biochemical Reaction;Biochemistry;Biological Models;BIRC5 gene;Buffers;Bypass;Cells;Centromere;Chromosomal Instability;Chromosome abnormality;chromosome missegregation;Chromosome Segregation;Chromosomes;Chronic;Clinical;clinical diagnostics;Clinical Trials;Clonal Expansion;Complex;diagnostic assay;Differential Equation;Diffusion;Disease;Engineering;ERBB2 gene;Event;Evolution;Exhibits;Feedback;FOXM1 gene;Genes;genome integrity;Gland;Goals;histone modification;Image;In Situ;in vivo;inner centromere protein;kinase inhibitor;Kinetochores;Lesion;Light;Link;Liquid substance;Loss of Heterozygosity;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Mediator;Metaphase;micronucleus;Microscopy;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Mitotic spindle;Mitotic/Spindle Checkpoint;Modeling;mosaic;mosaic analysis;multidisciplinary;mutant;Mutate;novel;Oncogenic;Operative Surgical Procedures;Organelles;Organoids;Pathology;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Physical condensation;predictive modeling;Predisposition;Primary Neoplasm;Productivity;Proteins;recruit;Regulation;repaired;Rodent;Sampling;segregation;sensor;Signal Transduction;Sister Chromatid;small molecule inhibitor;Solid Neoplasm;Stress;System;Systems Analysis;Testing;Therapeutic;Tissues;TP53 gene;transcription factor;Translating;triple negative cancer;triple-negative invasive breast carcinoma;tumor;tumorigenesis;upstream kinase;virtual;Visualization;Work

PROJECT_TITLE: Robust-to-fragile transitions of a phase-separated mitotic organelle in triple-negative breast cancer


NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Adaptive responses of collecting duct intercalated cells are critical for maintenance of acid-base homeostasis. Although extensive work has been based upon the premise that extracellular pH has direct effects on intercalated cell function, we propose revised paradigm in which proximal tubule-derived ammonia in conjunction with regulated reabsorption in the TAL leads to ammonia-dependent regulation of intercalated cell phenotype and plasticity. The proposed studies will investigate this new paradigm in detail using a variety of approaches.

PI_NAMEs: WEINER, I. DAVID (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acids;Acute;Address;Alkalosis;Ammonia;Anions;Apical;Atrophic;base;Bicarbonates;bone metabolism;Cardiovascular system;Cell membrane;Cell Physiology;Characteristics;Chronic Kidney Failure;Clinical Medicine;Coupled;Disease;Disease Progression;DNA Sequence Alteration;Duct (organ) structure;Electron Microscopy;Enzymes;Event;Excretory function;extracellular;GDF15 gene;Gene Combinations;Gene Deletion;Generations;Genes;glucose metabolism;Glycoproteins;GPR4 gene;Health;hensin;Homeostasis;hyperkalemia;Hypokalemia;Impairment;improved;In Vitro;insulin sensitivity;Intercalated Cell;Intercalated Duct;Intervention Trial;Kidney;kidney interstitial tissue;Knockout Mice;Limb structure;Maintenance;Mediating;Metabolic acidosis;Metabolism;Modeling;Molecular;mortality;Mus;muscle form;muscle strength;Pathway interactions;Pattern;Persons;Phenotype;Physical Function;Play;Potassium;Procedures;Process;Proteins;Proton-Translocating ATPases;Protons;Publishing;Regional Perfusion;Regulation;Renal Replacement Therapy;response;RNA Splicing;Role;Series;Serum;Signal Pathway;Signal Transduction;Site;Stromal Cell-Derived Factor 1;Techniques;Thick;Thyroid Function Tests;transcription activator-like effector nucleases;Urine;Variant;Vesicle;Work

PROJECT_TITLE: Molecular Mechanisms Regulating Ammonia Metabolism

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Liver Disease;Microbiome;Nutrition

PI_NAMEs: KASHATUS, DAVID FRANCIS (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Address;adenoma;Anabolism;Area;Bacteria;Biochemical Pathway;Butyrates;cancer cell;cancer initiation;Cellular Metabolic Process;Circulation;Citric Acid Cycle;colon cancer cell line;Colorectal Cancer;colorectal cancer metastasis;Complex;Computer Models;Data;Dependence;Dietary Intervention;Environment;Event;Exhibits;Exposure to;fatty acid metabolism;Feeds;Generations;Glycolysis;Growth;gut bacteria;gut microbiota;HCT116 Cells;Hepatic;Hepatocyte;Heterogeneity;host microbiota;Human;human model;in vivo;Injections;Inner mitochondrial membrane;knowledge integration;KRAS oncogenesis;KRAS2 gene;Liver;liver metabolism;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;Membrane;Membrane Potentials;Metabolic;Metabolism;metastatic colorectal;Metastatic Neoplasm to the Liver;Microbe;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Mutation;Neoplasm Metastasis;Nutrient;nutrient metabolism;Oncogenes;Oncogenic;Organelles;Oxidative Phosphorylation;Pancreatic Ductal Adenocarcinoma;Patients;predictive modeling;Primary Neoplasm;Process;programs;Proliferating;Publishing;Reaction;Research Project Grants;Role;Shapes;Signal Transduction;Site;Stress;Structure;Surface;System;Systems Analysis;Systems Biology;Testing;Tissues;tumor;tumor growth;tumor heterogeneity;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Volatile Fatty Acids;Work;Xenograft procedure

PROJECT_TITLE: A systems-metabolism approach to identify mitochondria-dependent vulnerabilities in colorectal cancer


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH This SCORE proposals aims to gain a better understanding of the role of the gut microbiome and female sex hormones in the modulation of brain gut microbiome interactions in two of the most common disorders of the gastrointestinal tract, irritable bowel syndrome and chronic functional constipation. To achieve this goal it will study these interactions in 1) female patients during low estrogen states (perimenstrually, post menopausal); 2) by comparing these interactions between female and male patients and healthy control subjects and 3) by studying gut microbial and brain mechanisms underlying the effectiveness of cognitive behavioral therapy. Results obtained from the proposed studies are likely to lead to significant improvements in the treatment of these disorders.

PI_NAMEs: CHANG, LIN ;MAYER, EMERAN A (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affective;Anatomy;Anxiety;Arousal;Bile Acids;bioinformatics tool;Biological;Biological Markers;Brain;Brain imaging;Brain region;Brain Stem;career;Cell Nucleus;Characteristics;Chronic;Chronic Disease;Clinical;Clinical effectiveness;clinical phenotype;Cognitive;Cognitive Therapy;comorbidity;computerized data processing;Consensus;Constipation;coping;Data Analyses;Diffusion;Digestive System Disorders;Disease;Doctor of Philosophy;Effectiveness;Emotional;Estrogen decline;Estrogens;experience;Female;female sex hormone;Functional disorder;Functional Gastrointestinal Disorders;Funding;Gastrointestinal Diseases;Generations;Goals;Gonadal Steroid Hormones;gut microbiome;gut-brain axis;Image;imaging modality;improved;insight;Intestinal Diseases;Irritable Bowel Syndrome;Leadership;Luteal Phase;male;Mediating;Mediator;men;Menopause;Menstruation;microbial;microbiome analysis;neuromelanin;noradrenergic;novel;Outcome;Pain;Pathway interactions;Patients;Perception;Physiological;Play;Pontine structure;Postmenopause;Premenopause;Prevalence;Progress Reports;Public Health;Publications;Reproducibility;Research;Research Personnel;response;Rest;Role;Sensory;Severities;sex;Sex Differences;Signal Transduction;Structure;Subgroup;Symptoms;System;therapeutically effective;therapy outcome;tool;Treatment Effectiveness;Treatment outcome;treatment response;treatment strategy;Tryptophan;Visceral;Volatile Fatty Acids;Woman;women patients

PROJECT_TITLE: Sex related differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome


NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Neurosciences;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH Irritable bowel syndrome (IBS) is a disorder affecting 30 million Americans and is thought to arise in part from problems in the way the brain and gut interact. This Core provides the administrative support for the entire Center, including administrative staff, budgeting, communications across projects working on the brain and gut bacteria and meeting planning. It is therefore critical for the overall success of the projects in their efforts towards better understanding and treatment for IBS.

PI_NAMEs: MAYER, EMERAN A (contact)

PROJECT_TERMS: Advisory Committees;Affect;American;Biological;Brain;Budgets;career;Career Choice;Chronic;Collaborations;Communication;computerized data processing;Constipation;Data Analyses;Development;Disease;Education;Education and Outreach;Etiology;Financial Support;Fostering;Goals;gut bacteria;gut microbiome;human disease;improved;Infrastructure;Institution;Interdisciplinary Study;Irritable Bowel Syndrome;Knowledge;Leadership;Learning;lectures;medical specialties;meetings;member;Monitor;Neurobiology;Peer Review;Play;posters;Prevention;Productivity;programs;Public Health;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;research study;resilience;Role;Running;Series;sex;Sex Differences;Strategic Planning;Stress;Structure;success;Time;Training;trend;Woman;Women's Health

PROJECT_TITLE: Leadership Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

PI_NAMEs: LAZZARA, MATTHEW J (contact)

PROJECT_TERMS: Accounting;Animals;Automobile Driving;Avidity;Binding;Biochemical;Biological Assay;Bioluminescence;Cell Death;Cell membrane;Cells;Cessation of life;Chemoresistance;Chronic;combinatorial;Complex;Computer Models;Data;Data Set;data-driven model;Disease;DNA Damage;EGF gene;Endocytosis;Endosomes;Engineering;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Equilibrium;Exons;experimental study;Glean;Glioblastoma;Goals;Grain;Hybrids;Hypoxia;Image;immunocytochemistry;Impairment;improved;In Vitro;in vivo;inhibitor;intermolecular interaction;interoperability;Intervention;Least-Squares Analysis;Ligation;Location;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Membrane;Modeling;Monitor;Mutate;Mutation;NF1 mutation;novel strategies;Oncogenes;Oncogenic;Organelles;Pathway interactions;Patients;Phenotype;phosphoproteomics;Phosphorylation;Phosphotyrosine;PIK3CA gene;Pinocytosis;predictive modeling;Proliferating;protein protein interaction;Proteins;Proto-Oncogene Proteins c-akt;Proto-Oncogenes;PTEN gene;PTPN11 gene;Receptor Protein-Tyrosine Kinases;receptor-mediated signaling;refractory cancer;Regulation;Reporter;Research Personnel;Role;Route;Signal Transduction;Signaling Protein;src Homology Region 2 Domain;Stress;System;Systems Analysis;Systems Biology;Testing;tool;Transplantation;Tyrosine Phosphorylation;Work

PROJECT_TITLE: EGFR signaling network adaptations to overcome RAS-induced membrane stress in glioblastoma


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Muscular Dystrophy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: In limb-girdle muscular dystrophy type 2B (LGMD2B), the lack or malfunctioning of protein dysferlin results in progressive muscle damage, inflammation, and replacement by fat. In this project, we will develop a novel cell culture model of LGMD2B human skeletal muscle to provide a high-fidelity test bed for mechanistic explorations and pharmacotherapeutic studies of this devastating disease.

PI_NAMEs: BURSAC, NENAD  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3-Dimensional;acetyl-LDL;Adipose tissue;Age;Animal Model;Beds;Biochemical;Biopsy;Calcium;Cell Culture Techniques;Cell membrane;Cell Separation;Cells;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Clinical;Clinical Trials;Coculture Techniques;Complement;Complex;cytokine;Disease;disease model;disease phenotype;Disease Progression;drug discovery;DYSF gene;dysferlinopathies;Engineering;Environment;Esterification;Exercise;Exhibits;experience;Fatty acid glycerol esters;Functional disorder;Generations;Genes;Goals;Histologic;Homeostasis;Human;human induced pluripotent stem cells;human model;immune cell infiltrate;Impairment;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;interstitial cell;Intramuscular;Investigation;Limb structure;Limb-Girdle Muscular Dystrophies;lipid metabolism;Lipids;Macrophage;Mediating;Membrane;Membrane Proteins;Metabolic;Mitochondria;Modeling;Motility;Mus;Muscle;Muscle Cells;muscle engineering;Muscle Fibers;muscle progenitor cell;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Mutation;Myocardium;Myopathy;new therapeutic target;novel;organ growth;organ on a chip;Organelles;Pathogenicity;Patients;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenotype;Play;pre-clinical;Process;Proteins;Regulation;repaired;Reproducibility;response;response to injury;Role;Severity of illness;Signal Pathway;Skeletal Muscle;Source;Study models;System;Testing;therapeutic target;Time;Tissue Engineering;Tissue Model;Tissues;Toxin;translational study;uptake

PROJECT_TITLE: Engineering a Human Skeletal Muscle Tissue Model of LGMD2B

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


PHR: RELEVANCE TO PUBLIC HEALTH Irritable bowel syndrome (IBS) is a disorder affecting 30 million Americans and is thought to arise in part from problems in the way the brain and gut interact. This Core will provide innovative programs to enhance collaboration, training, education and recruitment of new investigators, and community outreach. It is therefore critical for the overall success of the projects in their efforts towards better understanding and treatment for IBS.

PI_NAMEs: CHANG, LIN  (contact)

PROJECT_TERMS: academic program;Affect;American;Awareness;Brain;career;career development;Chronic;Collaborations;Community Outreach;Constipation;Disease;Education;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;gut microbiome;gut-brain axis;Health education;innovation;Interdisciplinary Study;interest;Irritable Bowel Syndrome;Leadership;lectures;meetings;Mentors;microbiome research;Mission;novel;programs;Public Health;Recording of previous events;recruit;Research;Research Personnel;research study;sex as a biological variable;Sex Differences;social media;Students;success;symposium;Training;Translational Research;undergraduate student;Woman;Women's Health;Work

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Chronic Pain;Data Science;Digestive Diseases;Microbiome;Neurosciences;Pain Research;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH The Data Processing and Analysis Core will provide the advanced microbiome, metabolomics and neuroimaging tools and technologies necessary to analyze the interactions of neurobiological and molecular mechanisms underlying the brain-gut-microbiome axis, sex differences in this system, the influence of hormones on this system, and how cognitive behavioral therapy alters this system. Elucidation of brain-gut- microbiome pathways cannot be achieved by analysis of microbiome and neuroimaging data sets in isolation. Integration of these distinctive `omics data sets to find biologically meaningful relationships, represents a frontier in bioinformatics that will be critical to identify novel diagnostic and therapeutic targets for IBS.

PI_NAMEs: CHURCH, ARPANA  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Anatomy;Arousal;Behavioral;Big Data;Bile Acids;Bioinformatics;Biological;biological systems;Biometry;Brain;Brain imaging;Brain Stem;Cell Nucleus;Central Nervous System;Chronic;Clinical;Clinical Data;Cognitive Therapy;Complex;computerized data processing;Constipation;Data;data acquisition;Data Analyses;Data Collection;data integration;Data Set;design;Diffusion;Disease;Emotional;Emotions;Ensure;Estrogens;Failure;Fatty Acids;frontier;Functional disorder;Functional Magnetic Resonance Imaging;Generations;Gonadal Steroid Hormones;gut microbiome;Hormones;Human;Image;Imaging technology;Individual;Information Systems;Irritable Bowel Syndrome;Knowledge;Link;Magnetic Resonance Imaging;Measures;Mediating;Menopausal Status;Menopause;Menstruation;metabolomics;Metagenomics;Methodology;microbiome;microbiome analysis;microbiota;Mission;Modeling;Molecular;Monitor;Multimodal Imaging;multimodality;Multiomic Data;multiple omics;multisensory;Neurobiology;neuroimaging;new therapeutic target;novel diagnostics;Pain;Pathway interactions;Phase;Phenotype;Protocols documentation;psychosocial;Public Health;Quality Control;Research Personnel;Resolution;response;Rest;Role;Severities;sex;sex as a biological variable;Sex Differences;Shotguns;spectrograph;statistics;Structure;Symptoms;System;Technology;Testing;therapy outcome;tool;treatment response;Tryptophan;Volatile Fatty Acids;Writing

PROJECT_TITLE: Data Processing and Analysis Core


NIH_SPENDING_CATS: Bioengineering;Cancer

PROJECT_TERMS: anti-cancer research;Applied Research;Award;Biomedical Engineering;career;Clinical;Clinical and Translational Science Awards;cohort;Collaborations;Communication;Communities;Country;design;Development;Discipline;Educational Curriculum;Effectiveness;Engineering;Ensure;Environment;Event;experience;Faculty;Funding;Future;Goals;Grant;Health;Historically Black Colleges and Universities;Human Resources;improved;Individual;innovation;Internships;Laboratories;Lead;Leadership;Malignant Neoplasms;marginalization;marginalized population;medical schools;Mentors;National Cancer Institute;Oncology;Organelles;Outcome;outreach;Persons;physical science;Positioning Attribute;posters;Productivity;programs;Publications;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;residence;Rest;Role;Science;Scientist;Series;Source;Specialist;Stress;student participation;Students;summer research;synergism;System;Systems Analysis;Systems Biology;Techniques;Technology;Testing;tool;Training;Training Support;translational health science;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;University of Virginia Cancer Center;Virginia;web site;Work

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: NS

ED_INST_TYPE: COMPUTER CENTER

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IRVINE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: In addition to genetic variants, a series of epigenetic, network, and genome organizational perturbations, and their complex interplays, have been reported to contribute to Alzheimer's disease and related dementias (ADRDs), so dissecting such multiple-scale gene regulation rules is the cornerstone to informing new cellular etiologies in such complex disorders. The recent single-cell revolution, especially the multimodal genomic profiling within the same cell, allows us to scrutinize ADRD dysregulations at the finest possible resolution, but its computational modeling is still in its infancy due to its ultra-high dimensionality, complex feature interactions, and high vulnerabilities to numerous confounding factors. This research aims to develop a suite of interpretable deep learning models and open-source software tools to construct personalized regulome via flexible single-cell multiome integration and highlight multi-scale dysregulations contributing to ADRD with detailed mechanistic explanations.

PI_NAMEs: ZHANG, JING  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Autopsy;Benchmarking;Biological Assay;Boundary Elements;Brain;Brain region;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cognitive ability;Collaborations;Communities;Complex;Computer Models;computer science;Computer software;Confusion;Data;data modalities;deep learning;deep learning model;differential expression;Dimensions;Disease;Dropout;effective therapy;Epigenetic Process;epigenome;epigenomics;Etiology;Event;Excision;Family;flexibility;functional genomics;Gender;Gene Expression Regulation;generative models;Genes;Genetic;genetic variant;Genome;genome annotation;Genome engineering;genome wide association study;genomic data;genomic profiling;Genomics;Genotype;Graph;Health Care Costs;Heterogeneity;Hi-C;high dimensionality;Hybrids;Impaired cognition;Individual;infancy;Knowledge;Learning;learning strategy;Life;Link;member;Memory Loss;Methods;Modality;Modeling;Molecular;multimodal data;multimodality;Multiomic Data;multiple omics;neural;Neurosciences;novel;older adult;open source;Patients;Pattern;Personal Satisfaction;Phenotype;predictive modeling;Prevention strategy;reconstruction;Regulatory Element;Reporting;Research;Resolution;Risk Factors;risk variant;Sampling;Scheme;sequencing platform;Series;single cell genomics;single cell sequencing;Software Tools;Specificity;supervised learning;System;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;treatment strategy;Variant

PROJECT_TITLE: Interpretable Deep Learning Methods to Investigate Genetics and Epigenetics of Alzheimer's Disease at a Single-Cell Resolution


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ROHDE, GUSTAVO KUNDE (contact)

PROJECT_TERMS: Antibodies;Area;Biological;cancer cell;Cell membrane;Cells;Cellular Structures;Chromosomes;Collaborations;Colorectal Cancer;colorectal cancer metastasis;Complex;computing resources;Cultured Cells;Data;Data Science;Data Set;Development;Endosomes;Enzymes;Epidermal Growth Factor Receptor;Excision;Experimental Models;feature detection;feature extraction;Fluorescence;Fluorescence Microscopy;Generations;Glioblastoma;Goals;Image;Image Analysis;image registration;imaging approach;Imaging Device;imaging modality;imaging Segmentation;Imaging Techniques;Immunofluorescence Immunologic;In Vitro;in vivo;Indirect Immunofluorescence;Individual;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Metabolic;Metaphase;Metastatic Neoplasm to the Liver;microscopic imaging;Microscopy;Mitochondria;Mitotic;Modeling;Molecular;Molecular Analysis;Morphology;novel;Organelles;Organoids;Pattern;Population;Post-Translational Protein Processing;Primary Neoplasm;Procedures;programs;protein protein interaction;Proteins;Protocols documentation;quantitative imaging;recruit;Reproducibility;Research Personnel;Research Project Grants;Resolution;Sampling;Scientific Advances and Accomplishments;Services;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Stains;Statistical Models;Stress;Subcellular structure;support tools;Surface;Systems Analysis;Systems Biology;Techniques;Testing;Texture;Tissue imaging;Tissues;tool;tumor;United States National Institutes of Health;Vacuole;Validation

PROJECT_TITLE: High-Content Imaging & Analysis Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Contraception/Reproduction;Digestive Diseases;Estrogen;Menopause;Microbiome;Neurosciences;Pain Research;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH This grant will provide new insights into the cause of irritable bowel syndrome (IBS) and constipation, which are common conditions that affect women more than men and are associated with a poorer quality of life, increased health care visits and costs and a lack of effective treatments. This research project studies the altered communication between the brain, gut, microbiome, and estrogen that are associated with more severe symptoms in women with IBS and constipation. Our findings have the potential to lead to the development of new treatments for these conditions.

PROJECT_TERMS: Abdominal Pain;Affect;Arousal;Bile Acids;Brain;brain magnetic resonance imaging;Brain Stem;Butyrates;Cell Nucleus;Chronic;Colon;Communication;Constipation;cost;Data;Defecation;Development;Disease;effective therapy;Emotional;Emotions;endophenotype;Estrogen decline;Estrogens;executive function;experience;Female;Functional disorder;Funding;gastrointestinal symptom;Genes;Grant;gut microbiome;gut-brain axis;Health Care Visit;insight;Investigation;Irritable Bowel Syndrome;Link;Luteal Phase;male;Measures;Mediating;men;Menopause;Menstrual cycle;Menstruation;metabolomics;Metagenomics;Microbe;microbial;microbiome;Modeling;multimodality;neuroimaging;novel;Pain;patient subsets;Perception;Phase;Plasma;Play;Pontine structure;Postmenopause;Premenopause;Prevalence;Progesterone;proliferative phase Menstrual cycle;Public Health;Quality of life;Research Project Grants;response;Rest;Ribosomal RNA;Role;sensory input;Severities;Sex Differences;Shotguns;Signal Transduction;Symptoms;System;Testing;Tryptophan;Visceral;Woman;women subjects;women versus men

PROJECT_TITLE: The role of brain-gut microbiome interactions in mediating IBS and constipation symptoms during menses and menopause


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Teenage Pregnancy;Underage Drinking

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Addressing substance use and sexual health disparities among urban American Indian and Alaska Native (AIAN) and Black youth requires multilevel approaches that address the underlying structural conditions that promote inequities; however, researchers rarely employ this complex approach likely due to lack of or inept use of theoretical frameworks. Developing and operationalizing a strengths-based conceptual framework grounded in the socioecological model is critical to inform a multilevel intervention to reduce these inequities. The proposed research study will examine associations among structural contexts, interpersonal level factors, risk and resilience to substance use and sexual risk-taking among Black and AIAN youth to inform the development of a comprehensive conceptual model to be used to guide the development of a multilevel intervention.

PI_NAMEs: TUITT, NICOLE R (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Adolescent;adolescent health;Adolescent Risk Behavior;adolescent substance use;Age;Alaska Native;Alcohol consumption;Alcohols;American Indians;Articulation;Behavior;Biometry;Black race;Characteristics;Child;children of color;Communities;Comparative Study;Complex;condoms;consistent condom use;Data;data integration;Development;Disadvantaged;Discrimination;Drug usage;Education;educational atmosphere;Ensure;Equation;Ethnic Population;Evaluation;experience;Exposure to;Failure;Foundations;Geography;Goals;Group Affiliation;health disparity;health equity;Health equity research;health inequalities;high risk;high school;improved;Individual;Inequity;infancy;Intervention;Interview;Literature;marijuana use;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;multidisciplinary;native youth;Neighborhoods;Not Hispanic or Latino;opioid use;Outcome;Parent-Child Relations;Parents;Pattern;peer;Peer Group;Physical environment;Positioning Attribute;Poverty;Pregnancy in Adolescence;Prevention;Public Health;racial disparity;racial identity;racial population;Recording of previous events;reduced substance use;Reporting;Research;Research Personnel;research study;residential segregation;resilience;Resources;Risk;Risk Behaviors;Risk Reduction;School-Age Population;Schools;Science;segregation;sex;Sexual Health;Sexual Partners;sexual risk taking;Sexually Transmitted Diseases;skills;Social Environment;social epidemiology;spatial epidemiology;stem;structural determinants;Structure;Students;substance use;teacher;Tobacco use;Training;Translating;urban Native American;vaping;Work;Youth

PROJECT_TITLE: Advancing Methods for Multilevel Interventions to Support Health Equity for Urban American Indian/Alaska Native and Black Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Clinical Research;Digestive Diseases;Microbiome;Neurosciences;Pain Research;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH Even though IBS is now considered a brain gut disorder, the underlying biological mechanisms, and the role of sex related differences are incompletely understood. We propose to study sex related differences in the structure and function of brain networks that are relevant for IBS, and characterize the modulation of these networks but gut microbial metabolites and estrogen. The results from the proposed studies are likely to identify novel targets for IBS drug development with particular relevance for female patients.

PI_NAMEs: LABUS, JENNIFER S (contact)

PROJECT_TERMS: Abdominal Pain;Address;Afferent Pathways;Anatomy;Arousal;Behavioral;Bile Acids;Biological;Biological Markers;blood-brain barrier crossing;Brain;Brain Stem;Cell Nucleus;Characteristics;Chronic;Circulation;Classification;Clinical;comorbidity;Consensus;Data;Data Set;Databases;Development;Diagnostic Procedure;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dorsal;drug development;effective therapy;Emotional;Enrollment;Estrogens;expectation;Female;female sex hormone;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Generations;Goals;gut microbiome;Habits;Health Care Costs;Hypersensitivity;Image;Imaging Techniques;Imaging technology;insight;Intestinal Diseases;Intestines;Investigation;Irritable Bowel Syndrome;Kynurenine;Laboratories;learning network;Machine Learning;Magnetic Resonance Imaging;male;Measurable;Measurement;Measures;metabolomics;Metagenomics;microbial;MRI Scans;Multimodal Imaging;multimodality;neural network;neuromelanin;Neuronal Plasticity;novel;Pain;Pathway interactions;patient subsets;Patients;personalized intervention;Physiological;Plasma;Play;Pontine structure;Property;Public Health;recruit;Recurrence;Reporting;Research;Resolution;Rest;Role;Sensory;sex;Sex Differences;Shotguns;Signal Transduction;Spinal;Stimulus;Stress;structural imaging;Structure;Symptoms;Testing;transcriptome sequencing;treatment strategy;Tryptophan;Volatile Fatty Acids;women patients

PROJECT_TITLE: Sex -related differences in structure, function and connectivity of central arousal and salience networks involving brainstem nuclei are involved in IBS symptom generation.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The first cell differentiation in mammals produces two cell types, the inner cell mass (ICM) and the trophectoderm (TE), which give rise to the embryo proper and the placenta, respectively. Investigating the mechanisms that regulate the specification of these cell types is therefore critical for understanding early pregnancy and the factors that contribute to infertility. In this proposal I investigate how mechanical properties of the nucleus contribute to the specification of the ICM and TE, shedding light on this important early developmental period, and having broader implications for generally understanding cellular transitions during development.

PI_NAMEs: SHERRARD, ALICE LOUISA (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adhesions;Affect;Automobile Driving;Binding;Biological Assay;blastocyst;Cell Differentiation process;cell fate specification;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Modeling;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Critical Pathways;Cryoelectron Microscopy;Cytoplasm;Cytoskeleton;Detection;Development;early pregnancy;Education;Electron Microscopy;Embryo;embryo cell;embryo tissue;Embryonic Development;experimental study;Fertilization;Gene Expression;Generations;Genetic Transcription;Genomics;Germ Layers;Goals;Heterochromatin;Image;Immunofluorescence Immunologic;implantation;in vivo;Infertility;Inner Cell Mass;insight;Label;Lamin Type A;Learning;Light;Link;Maintenance;Mammalian Cell;Mammals;mechanical force;mechanical properties;mechanical signal;Mechanics;Membrane Proteins;Mentors;Methods;Molecular;Mus;novel;novel strategies;Nuclear;Nuclear Envelope;Nuclear Matrix;Nucleosomes;Pathway interactions;Placenta;pluripotency;post-doctoral training;Postdoctoral Fellow;Pregnancy;preimplantation;Process;programs;Proteins;Protocols documentation;Regulation;Regulatory Pathway;Research;Resistance;Resolution;Role;Running;Scientist;sensor;Signal Pathway;Signal Transduction;Specialist;Specific qualifier value;Supporting Cell;Techniques;Testing;tomography;Training;transcriptome sequencing;transmission process;Visualization;Work

PROJECT_TITLE: Investigating the role of nuclear mechanics in the regulation of chromatin structure and embryonic cell fate

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Digestive Diseases;Mental Health;Microbiome;Neurosciences;Pain Research;Precision Medicine;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH Cognitive behavior is an effective therapy in IBS, but the biological mechanisms underlying its effectiveness, and the role of sex as a biological variable are not known. The proposed studies aim to study the role of the gut microbiome and its interactions with brain and brainstem regions, as well as clinical and behavioral variables, and determine the role of SAVB in these interactions and in clinical outcomes. The results from these studies have the potential to identify subgroups of patients highly responsive to therapy, as well as underlying biological mediators.

PROJECT_TERMS: Aftercare;Anatomy;Arousal;Bacteroides;Behavior;Behavioral;Biological;Biological Markers;Brain;Brain Stem;Cell Nucleus;Characteristics;Clinical;Cognitive;cognitive benefits;Cognitive Therapy;comorbidity;Data;Disease;effective therapy;Effectiveness;Emotional;expectation;Female;Functional disorder;Funding;Goals;gut microbiome;High Prevalence;Irritable Bowel Syndrome;locus ceruleus structure;Longitudinal Studies;Maintenance;male;Measures;Mediator;men;microbial;microbiome;multisensory;neuroimaging;noradrenergic;Outcome;Pain;Pathway interactions;patient subsets;Patients;Perception;personalized intervention;Plasma;Play;Prevalence;Public Health;Publications;Research;response;Rest;Role;Sensory;sex;sex as a biological variable;Sex Differences;Stimulus;Subgroup;Symptoms;System;Technology;Testing;Therapeutic Effect;therapy outcome;treatment as usual;Treatment outcome;treatment responders;Woman;Women's prevalence

PROJECT_TITLE: Sex related differences in the effect of cognitive behavioral therapy on emotional arousal and salience circuits and the role of the gut microbiome


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Principal Investigator (Wright, Erik S.) Project Narrative: Genomes harbor an immense amount of untapped information that could provide valuable insights into the interactions and functions of genes within cells. This work will develop a network of coevolving genes spanning many different microorganisms and make it publicly accessible as an online tool for biomedical research.

PI_NAMEs: WRIGHT, ERIK SCOTT (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Acceleration;Acute;Address;Algorithms;Antibiotic Resistance;Archaeal Genome;Architecture;Astronomy;Bacterial Genome;base;Benchmarking;Bioinformatics;Biomedical Research;Cell Physiology;Cells;Classification;Collection;Color;comparative genomics;Computer software;Computers;Consumption;dark matter;Darkness;Data;Databases;Disease;DNA;Drug Targeting;Evolution;Fruit;Fungal Genome;Genbank;gene function;Genes;Genetic;genetic information;Genome;genome annotation;Genomics;Guilt;Height;Hypothetical Protein;Inequality;innovation;insight;Knowledge;Label;Laboratories;Letters;Life;Light;Link;link protein;Machine Learning;Maps;Methods;microbial;microbial genome;microorganism;Mutation;Names;neglect;new therapeutic target;novel;open data;open source;Organism;Orthologous Gene;Output;pan-genome;pathogen;Pathogenicity;Pathway interactions;pressure;Principal Investigator;programs;Proteins;Proteome;Regulation;Research;Resources;Role;Signal Transduction;Software Validation;Surface;System;Techniques;Time;tool;Trees;Virulence;web app;web site;web-based tool;Work

PROJECT_TITLE: Connecting the universe of proteins to address annotation inequality in the microbial proteome


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Every 30s someone in the world has a limb amputated, with ~300-500 each day in the United States alone, with an estimated total around 2.1 million people living with amputations in the U.S. Sophisticated robotic prosthetic limbs have dramatically increased the level of control a user could have, but evoking naturalistic sensation, such as touch and sense of where the limb is remains a formidable challenge. We propose the development of a highly selective regenerative peripheral nerve interface that uses small electrodes, and molecularly guided sensory subtypes to improve neural interfacing of amputated nerves that will hopefully allow users to touch and feel their loved ones once again.

PI_NAMEs: FRANCIS, JOSEPH T (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Adult;afferent nerve;Amputation;Amputees;Anesthesia procedures;Area;arm;awake;Axon;Brain;cognitive load;comparison control;Cues;Cutaneous;design;Deterioration;Development;Electrodes;Electromyography;Esthesia;Failure;Feedback;Freedom;grasp;Hand;Human;Implant;improved;innovation;Intention;Lateral;Legal patent;limb amputation;limb movement;Limb Prosthesis;Limb structure;Locomotion;loss of function;loved ones;machine learning method;Maps;median nerve;Methodology;Methods;Microelectrodes;microstimulation;Modality;Modeling;Molecular;Motor;motor control;Motor Cortex;Muscle;Natural regeneration;Nerve;nerve transection;neural;neural prosthesis;neurophysiology;neuroprosthesis;Paraplegia;Paresthesia;Pathway interactions;Patients;Pattern;Performance;Peripheral;Peripheral Nerves;Peripheral Nervous System;Persons;powered prosthesis;Proprioception;Prosthesis;prosthesis control;Publishing;Rattus;Recovery;regenerative;residual limb;Residual state;response;robot control;Robotics;sensor;Sensory;sensory feedback;sensory input;Shapes;Signal Transduction;somatosensory;Somatosensory Cortex;Sting Injury;Surface;System;Tactile;Testing;Thalamic structure;Time;Touch sensation;Translating;treadmill;United States;Upper Extremity;Visual;visual feedback

PROJECT_TITLE: Regenerative Micro-Electrode Peripheral Nerve Interface for Optimized Proprioceptive and Cutaneous specific interfacing

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Vaccination is a powerful intervention to reduce the burden of influenza infections, yet how repeated vaccination shapes the long-term development of protective immune responses to influenza is not clear. This research involves measuring immune responses of participants in a randomized, clinical trial of the inactivated influenza vaccine and using such data to fit predictive models of how vaccination and infection change immunity to influenza over time. This will provide important basic information for improving vaccination strategies against influenza.

PI_NAMEs: COBEY, SARAH  (contact);COWLING, BENJAMIN JOHN

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Adult;Affect;Age;Antibodies;Antibody Response;Antibody Specificity;Antibody titer measurement;Appearance;Attenuated;B-Lymphocytes;Binding;Biological Specimen Banks;Birth;Cells;Circulation;Complex;Coupled;Data;design;Development;Effectiveness;Epitopes;Evolution;Frequencies;Future;Genetic Transcription;Genotype;high dimensionality;Hong Kong;Immune;Immune response;Immunity;immunogenicity;Immunologic Memory;immunological status;Immunologics;imprint;improved;Individual;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;Injections;insight;Intervention;Measures;Modeling;nasal swab;Nose;Observational Study;Participant;Pattern;Persons;Phenotype;Placebos;Population;predictive modeling;Predisposition;primary endpoint;Process;Proxy;Public Health;Randomized;randomized, clinical trials;Recommendation;Recording of previous events;Research;Residual state;response;Reverse Transcriptase Polymerase Chain Reaction;Saline;Sampling;seasonal influenza;secondary endpoint;Serum;Shapes;Specificity;Specimen;standard measure;Statistical Models;T cell response;Testing;theories;Time;universal vaccine;Vaccinated;Vaccination;vaccination strategy;vaccine effectiveness;vaccine efficacy;vaccine failure;vaccine response;Vaccinee;Vaccines

PROJECT_TITLE: The "Dynamics of the immune responses to repeat influenza vaccination exposures" (DRIVE) Study

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Women's Health Research

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: NARRATIVE Despite the importance that mitochondria play in controlling cell metabolism, few studies have addressed how mitophagy regulates the metabolic state associated with functionally differentiated cells in vivo. Determining the interconnections between SIM2, mitophagy, cell metabolism, and differentiation will provide a better understanding of normal development and associated pathologies. We expect results from these studies will help define the mechanism of mitochondrial adaptation in multiple processes, including normal development and lactation disorders, and breast cancer.

PI_NAMEs: PORTER, WESTON W (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Architecture;Attention;Autophagocytosis;Breast Epithelial Cells;Cell Differentiation process;Cells;Cellular Metabolic Process;Cellular Stress;Citrates;Complex;Cues;Data;Development;differential expression;Disease;Environment;Epigenetic Process;Epithelium;functional outcomes;Gene Expression Regulation;Glucose;Histone Acetylation;Homeostasis;Hormones;Human;in vivo;inhibitor;insight;Lactation;Lactation Disorders;Ligase;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;mammary gland development;member;Metabolic;Metabolic Diseases;Metabolism;Mind;Mitochondria;Modeling;Morphology;Mouse Mammary Tumor Virus;mouse model;Mus;Neurodegenerative Disorders;Parkin;Pathology;Pathway interactions;Phosphorylation;Physiological;PINK1 gene;Play;postnatal;Process;Protein Family;Proteins;Publishing;Pyruvate;Recycling;Regulation;response;Role;Signal Pathway;Signal Transduction;Tissues;transcription factor;Transgenic Mice;ubiquitin-protein ligase

PROJECT_TITLE: Mitophagy Dependent Regulation of Mammary Gland Differentiation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Using a focused implementation research framework, the EPIS (Exploration, Preparation, Implementation and Sustainment) model in a type-2 hybrid design, we will conduct this study in 3 phases: 1) A pre-implementation phase that will use the Exploration and Preparation domains of EPIS to: a) explore barriers and facilitators of CF-CS use, and b) develop a culturally-tailored CM strategy for CF-CS use; 2) An Implementation phase that will use the Implementation domain of EPIS to compare in a cluster RCT of 32 periurban communities (640 households), the effect of CM vs. a self-directed condition (i.e. receipt of information on CF-CS use without CM) on adoption of CF-CS use; and systolic BP reduction; 3) A post-implementation phase that will use the Sustainment domain of EPIS to evaluate the effect of CM strategy vs. self-directed condition on sustainability of the CF-CS use in 640 households across the randomly assigned 32 periurban communities in Nigeria. University of Ibadan working with the MOH will oversee research coordination in Nigeria. The

PI_NAMEs: OGEDEGBE, OLUGBENGA G. (contact);OLOPADE, CHRISTOPHER O

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Adoption;Adult;Africa;Air;Annual Reports;attributable mortality;behavior change;Biomass;biomass fuel;Blood Pressure;blood pressure reduction;Chicago;Collaborations;Communities;Community Actions;community advisory board;community barrier;community building;Community Health;community organizations;cooking;Cookstove;Country;Devices;Disease;Epidemic;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;follow-up;Government Officials;Health;Household;Household Air Pollution;hybrid type 2 design;Hypertension;hypertension prevention;implementation framework;implementation strategy;improved;Intervention;Kerosene;Leadership;low and middle-income countries;Maintenance;Measures;medical schools;member;Modeling;Monitor;Morbidity - disease rate;mortality;Needs Assessment;Nigeria;Outcome;Participant;peri-urban;Phase;pilot test;Population;post implementation;premature;Preparation;primary outcome;Randomized;Readiness;Research;research to practice;Resources;secondary outcome;Self Direction;solid fuel;System;Training;Universities;uptake;Urban Community;Woman

PROJECT_TITLE: Community Mobilization for Improved Clean Cookstove Uptake, Household Air Pollution Reduction, and Hypertension Prevention

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Sleep is a critical behavior that is essential to human health, and yet sleep dramatically deteriorates with age. The fundamental question that I will answer in this proposed research program is how sleep impacts brain resilience late in life. Findings from this work will change how we think about the long-term health impact of sleep and provide a novel yet accessible treatment to rejuvenate the aged and diseased brain.

PI_NAMEs: NATH, RAVI  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Adolescence;Advisory Committees;Affect;African;Age;age acceleration;age related;age related decline;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;animal old age;Animals;Award;Behavior;Behavioral;Biological Models;Biology of Aging;Brain;Brain Diseases;brain health;Caffeine;career development;Cessation of life;circadian;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cognitive performance;cognitive testing;Consumption;cost;CRISPR/Cas technology;Data Analyses;Dependence;Deterioration;Disease;Drug Modulation;Exhibits;experimental study;extend lifespan;frailty;Generations;Genes;Genetic;genetic manipulation;Gliosis;Goals;Health;Histologic;Histology;Human;human data;human old age (65+);Impaired cognition;improved;improvement on sleep;Inflammation;Institution;Killifishes;Knock-in;Knock-out;Knowledge;Laboratories;Learning;Life;life span;longitudinal dataset;Mediating;Melatonin;Memory;Mentors;Methods;middle age;Modafinil;Modeling;Molecular Profiling;Monitor;Morbidity - disease rate;Nerve Degeneration;Neurofibrillary Tangles;Neuroglia;Neurons;neurotoxicity;novel;overexpression;Oxidative Stress;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;programs;protein aggregation;Proteins;Regulation;Rejuvenation;repaired;Research;resilience;resilience in aging;Risk;Role;single nucleus RNA-sequencing;skills;Sleep;sleep behavior;Sleep Deprivation;Sleep disturbances;sleep quality;Stains;Structure;System;Testing;Time;tool;Training;trait;transcriptome sequencing;transcriptomics;Universities;Vascular Dementia;Vertebrates;Wakefulness;Waste Products;Western Blotting;Work;β-amyloid burden

PROJECT_TITLE: Investigating the role of sleep in brain resilience during aging using a scalable and short-lived vertebrate model

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The proposal aims to establish a resource to optimize and validate quantitative imaging methods to assess or predict response to therapy using patient-derived tumors implanted in mice and the implementation of the quantitative methods in clinical imaging to facilitate assessment of therapy in metastatic breast cancer.

PI_NAMEs: DING, LI ;LI, SHUNQIANG ;MA, CYNTHIA X;SHOGHI, KOORESH ISAAC (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Address;adjuvant endocrine therapy;advanced breast cancer;Algorithms;Animal Model;anti-cancer research;arm;Award;Biological Markers;Breast Cancer Patient;cancer diagnosis;CDK4 gene;chemotherapy;Clinical;clinical database;clinical imaging;clinical investigation;Clinical Research;Clinical Trials;co-clinical trial;Combined Modality Therapy;Communities;Data;deep learning algorithm;Dependence;Disease;Disease Progression;efficacy evaluation;Epidermal Growth Factor Receptor;ESR1 gene;Estradiol;Estrogen receptor positive;Estrogen Receptor Status;Estrogen Receptors;Estrogens;exome sequencing;experience;FRAP1 gene;functional status;Future;genetic signature;Heterogeneity;hormone therapy;Human;Image;imaging agent;imaging modality;Implant;improved;indexing;inhibitor;Malignant Breast Neoplasm;Metadata;Metastatic breast cancer;Metastatic/Recurrent;Methods;Mus;mutational status;novel;Pathology;Patients;PET/CT scan;Phase;PIK3CG gene;Positron-Emission Tomography;pre-clinical;precision medicine;preclinical study;predicting response;Prediction of Response to Therapy;Predictive Value;Progesterone Receptors;Proteins;public health relevance;quantitative imaging;receptor expression;Receptor Gene;reconstruction;Recurrence;Reproducibility;Resistance;resistance mechanism;Resource Informatics;Resources;response;Risk;RNA;Signal Pathway;Site;Specificity;standard of care;targeted treatment;Testing;transcriptome sequencing;Treatment Efficacy;tumor;tumor heterogeneity;tumor xenograft;Universities;Vendor;virtual;Washington;web portal;web-accessible;Woman;women's diagnosis;X-Ray Computed Tomography

PROJECT_TITLE: Washington University Co-Clinical Imaging Research Resource


NIH_SPENDING_CATS: Clinical Research;Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative Summary Facioscapulohumeral muscular dystrophy (FSHD) a genetically dominant progressive muscular dystrophy associated with inappropriate expression of the DUX4 gene. This application focuses on understanding how DUX4 functions and how it perturbs cells, on investigating mechanisms of disease in human cells, and on testing a new therapeutic intervention in a new DUX4-based animal model. This work thus helps us understand the disease and also has the potential to lead to therapies for FSHD based in inhibiting DUX4 activity.

PI_NAMEs: KYBA, MICHAEL  (contact)

PROJECT_TERMS: 4q35;Address;Affect;Alleles;Animal Model;Biological Models;Biopsy;Blood capillaries;Cell Fraction;Cell model;cell type;Cells;Cessation of life;Chromatin;Chronic;Confusion;Cytopathology;cytotoxic;D4Z4;Data;density;Deposition;Disease;DNA Binding;DNA lesion;Dose;droplet sequencing;EP300 gene;Facioscapulohumeral Muscular Dystrophy;Failure;Fatty acid glycerol esters;Fiber;Fibrosis;Gene Expression;Gene Expression Profile;gene repression;Gene set enrichment analysis;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genomics;histone acetyltransferase;Histone H3;homeodomain;Human;human disease;human model;Immune;improved;in vivo;Incidence;Individual;Inflammation;inhibitor;insight;Measures;Mediating;Modeling;Molecular;Molecular Conformation;Mononuclear;mouse model;Mus;Muscle;Muscle satellite cell;Muscular Atrophy;Muscular Dystrophies;Myoblasts;Myopathy;Names;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Population;Prevalence;progenitor;Proteins;regeneration potential;Research;Resources;Role;Series;Severity of illness;Skeletal Muscle;stem cells;telomere;Testing;Therapeutic;Tissues;Toxic effect;transcription factor;Transcriptional Activation;United States;Work

PROJECT_TITLE: Probing the activity of DUX4 in FSHD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer with unique metabolic rewiring making it highly refractory to the current standards of care. We have shown that these tumors become reliant on particular metabolic pathways creating metabolic bottlenecks. In this proposal we will comprehensively define the metabolic dependencies of PDA tumors in vivo and assess the therapeutic potential of these pathways in mouse models of cancer.

PI_NAMEs: BIANCUR, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;anti-cancer research;Biological Models;Biology;cancer cell;Cancer Model;Cancer Patient;cancer therapy;candidate identification;career;Caring;Cause of Death;Cells;CRISPR library;CRISPR screen;CRISPR/Cas technology;Critical Pathways;Custom;Data;Dependence;design;Detection;Disease;Disseminated Malignant Neoplasm;Distal;Dropout;Experimental Models;experimental study;Fellowship;Follow-Up Studies;Foundations;Genes;Genetic;Genetic Screening;Genetic Techniques;Goals;Growth;hands-on learning;Heme;heme biosynthesis;Immune;Immune Evasion;Immune system;Immunocompetent;Immunocompromised Host;Immunologic Surveillance;Immunology;In Vitro;in vitro Model;in vivo;Incidence;insight;KRAS2 gene;Laboratories;Lead;Link;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Masks;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Metastatic Neoplasm to the Liver;Modeling;mortality;mouse model;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Nutrient;Oncogenes;Organ;Oxygen;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway Analysis;Pathway interactions;Patients;Phase;Physiological;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Primary Neoplasm;Prognosis;Refractory;Research;Research Personnel;Research Project Grants;Role;Series;Site;skills;Splenectomy;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;tissue culture;Training;transplant model;tumor;Tumor Burden;tumor growth;tumor metabolism;tumor microenvironment;Validation;Work

PROJECT_TITLE: Identifying Metabolic Vulnerabilities in Pancreatic Cancer


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE  This R01 application proposes conducting a fully powered trial to test the effectiveness of a patient navigation intervention for Black/African American (B/AA) men who have sex with men (MSM) on PrEP initiation, adherence and retention in care. This study is informed by an R34 pilot intervention that was associated with improvements in PrEP initiation, adherence and retention in care for this population. The objectives of the proposed study are to conduct a fully powered randomized controlled trial and to estimate the effectiveness and cost-effectiveness of the intervention for improving PrEP care outcomes among B/AA MSM in real-world community health center settings.

PI_NAMEs: CHAN, PHILIP ANDREW;NUNN, AMY STEWART (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Adherence;African American;Attention;Bisexual;black men who have sex with men;Black race;Blood;care outcomes;Caring;Clinic;Clinical;Collaborations;Communication;comparison control;Complex;Consensus;Continuity of Patient Care;cost;Cost Analysis;cost effective intervention;cost effectiveness;cost estimate;Data;Disparity;District of Columbia;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Enrollment;Epidemic;experience;Funding;Gays;Geography;Goals;health care service;Health Insurance;high risk men;HIV;HIV Infections;HIV/AIDS;implementation study;improved;Incidence;Intervention;intervention cost;Measures;men who have sex with men;Methods;Mississippi;Modeling;Neighborhood Health Center;Not Hispanic or Latino;Oral;Outcome;Participant;patient navigation;Patients;Persons;Pharmaceutical Preparations;Pharmacy facility;Pilot Projects;Population;pre-exposure prophylaxis;prevent;primary outcome;programs;Ramp;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;Rhode Island;Risk;Schedule;secondary analysis;Services;Sex Orientation;Site;social;social factors;social stigma;standard of care;structural determinants;Telephone;Testing;Text Messaging;Time;Transportation;treatment as usual;Uninsured Medical Expense;United States;United States National Institutes of Health;Visit;Washington;Work

PROJECT_TITLE: Intervention to Enhance PrepPersistence Among African American Men Who Have Sex With Men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Bile acids, which are important for promoting fat digestion in the intestine, are made in liver and circulate repeatedly between liver and intestine through the bile and the blood. The transport of bile acids must be tightly controlled, because excess levels of bile acids in blood or tissues can be toxic. We have found that bile acid transport is regulated by the hormone insulin, and this grant is designed to determine how this regulation occurs.

PI_NAMEs: HAEUSLER, REBECCA ANNE (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Affect;Appearance;Basic Science;Bile Acid Biosynthesis Pathway;bile acid transporter;Bile Acids;Bile fluid;Biliary;Biology;biomarker validation;Blood;Body Weight decreased;Brain;Cannulations;Cell model;Cells;Closure by clamp;cytotoxic;Data;design;Destinations;Diazoxide;diet-induced obesity;Digestion;Distal;Dyslipidemias;Enterohepatic Circulation;Fatty acid glycerol esters;Gallbladder;Glucose Clamp;glucose metabolism;Grant;Health;Hepatic;Hepatocyte;Hormones;Hour;Human;human subject;Hyperinsulinism;Hypoglycemia;Impairment;in vitro Model;in vivo;Individual;Injections;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Intention;Intestines;Investigation;Kinetics;Knock-out;Knockout Mice;Laboratories;lipid metabolism;Liver;liver function;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolic;Metabolism;Methods;Modeling;mouse model;Mus;Non obese;Nutrient;Obese Mice;Obesity;Operative Surgical Procedures;Pancreas;Pathway interactions;Pharmaceutical Preparations;prevent;Proteins;Proteomics;Radiolabeled;Receptor Signaling;Regulation;Serum;Signal Transduction;Site;success;System;Testing;Tissues;Tracer;uptake;Work

PROJECT_TITLE: Insulin regulation of hepatic transport

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: We will develop a new suite of quantitative molecular imaging tools to measure spatial and temporal changes of distribution of signaling molecules known as chemokines in multicellular environments. These tools will allow investigators to answer basic questions about how chemokines signal and function and cancer, which will open opportunities to better target these molecules for cancer therapy.

PI_NAMEs: LUKER, GARY D (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: angiogenesis;Automobile Driving;Binding;Biochemistry;Bioluminescence;bioluminescence imaging;Breast Cancer Cell;cancer cell;cancer therapy;cell motility;Cell Proliferation;Cell surface;cell type;Cells;cellular imaging;chemokine;chemokine receptor;chemokine therapy;Chemotaxis;clinical translation;complement system;Complex;Computer Models;Coupling;CXCL11 gene;CXCR3 gene;CXCR4 gene;CXCR4 Receptors;Data Set;drug development;Drug Targeting;Environment;Event;Exhibits;extracellular;Extracellular Matrix;fluorescence imaging;Fluorescence Microscopy;Future;G-Protein-Coupled Receptors;Heterogeneity;high dimensionality;Human;Image;Image Analysis;image processing;Imaging Device;imaging study;Imaging technology;Immune;improved;innovation;intercellular communication;Invaded;Investigation;large scale data;Ligands;live cell imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediator;Methods;Molecular;molecular imaging;multiplexed imaging;Neoplasm Metastasis;Organism;Output;Pathway interactions;Patients;Pattern;Performance;Phosphotransferases;Positioning Attribute;Process;Proliferating;Protein Isoforms;quantitative imaging;receptor;receptor binding;Receptor Signaling;recruit;Reporter;Research;Research Personnel;Resolution;response;Role;scavenger receptor;Shapes;Signal Transduction;Signaling Molecule;Site;Spatial Distribution;Specificity;Stromal Cell-Derived Factor 1;Stromal Cells;System;targeted treatment;Technology;technology development;Testing;therapy design;tool;treatment optimization;tumor;Tumor Biology

PROJECT_TITLE: Integrated Imaging Tools for Intercellular Chemokine Signalling


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Candida albicans is a commensal fungus that colonizes the intestine of most healthy people but has the capacity to cause infections and exacerbate inflammation in susceptible people. Immune status determines risk for C. albicans-associated disease, but the impact of immune environment on C. albicans inherent pathogenic potential is not well understood. This proposal aims to comprehensively define the impact both homeostatic and pathogenic immune environments on C. albicans pathogenic potential.

PI_NAMEs: OST, KYLA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adherence;Animal Model;Antibodies;Automobile Driving;Benign;Biology;Candida;Candida albicans;cell injury;cell type;Cells;Colitis;commensal microbes;Communities;Development;Disease;Environment;Foundations;Fungal Genes;fungus;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Goals;gut colonization;gut inflammation;gut microbiome;gut microbiota;Health;Heterogeneity;Human;Hyphae;Immune;Immune response;Immunity;immunodeficiency;Immunoglobulin A;Immunological Models;immunological status;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestines;Invaded;Investigation;Knowledge;Life;Life Style;Link;Maintenance;member;Microbe;microbial;microbial community;microbiome;microbiota;Modeling;Morphology;mouse model;Mucous Membrane;murine colitis;Mus;novel;opportunistic pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Population;Predisposition;prevent;Process;programs;Recovery;Regulation;Risk;Role;Shapes;Study models;targeted treatment;Testing;Time;Work

PROJECT_TITLE: Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Infectious Diseases;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Iron deficiency is the most common single nutrient deficiency in the world and all preterm infants  need enteral iron supplementation to prevent iron deficiency and iron deficiency anemia.  Iron-rich environment can stimulate the growth of enteric pathogens and suppress the growth of  beneficial bacteria. This project will clarify the effects of enteral iron  supplementation on the developing microbiome and intestines in preterm infants and this knowledge  will potentially impact not just the care of preterm infants but also the care of children, and  adults with anemia.

PI_NAMEs: HO, THAO  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 3-Dimensional;absorption;Actinobacteria class;Adult;Affect;Anemia;Attenuated;Award;Bacteria;Basic Science;Bifidobacterium;Biometry;career;career development;Caring;Cell Culture Techniques;Cell model;Child;Child Care;Childhood;claudin 3;Clinical;Clinical Data;Clinical Research;Clinical Sciences;Collaborations;commensal bacteria;Complement;cytokine;Data;Data Set;Death Rate;design;Development;Development Plans;Disease;Dose;dysbiosis;Ensure;Enteral;enteric pathogen;Environment;Epithelium;Erythropoietin;Escherichia coli;experience;experimental study;Exposure to;Failure;fecal microbiome;Feces;fetal;Filtration;Firmicutes;Florida;Foundations;Funding;Future;Gene Expression;Genomics;Goals;Gram-Negative Bacteria;Growth;gut inflammation;gut microbiome;Health;Human;IL8 gene;Immunity;Immunology;improved;In Vitro;in vitro Model;Infant;Infant Health;Inflammation;Inflammatory;innovation;Interleukin-6;Intestinal Diseases;intestinal epithelium;intestinal fatty acid binding protein;Intestines;Iron;iron deficiency;Iron deficiency anemia;iron supplementation;Knowledge;Lactobacillus;Learning;Leukocyte L1 Antigen Complex;low income country;Measures;Mentors;Mentorship;microbial composition;Microbiology;microbiome;microbiome analysis;Modeling;Mucositis;Mucous Membrane;Necrotizing Enterocolitis;Neonatal;neurobehavioral;neurodevelopment;Nutrient;nutrition;pathogen;Pathogenicity;Patients;Permeability;Physicians;premature;Premature Infant;preservation;prevent;Prevention;Production;Proteobacteria;Proteus;Randomized;Recommendation;Regimen;Reporting;Research;research and development;Research Design;Research Personnel;response;Risk;Salmonella;Sampling;Scholarship;Scientist;Secure;Shigella;skills;Societies;Sterility;Technology;Testing;Thinking;Third Pregnancy Trimester;three-dimensional modeling;Time;Training;translational scientist;United States National Institutes of Health;Universities;Urine;Venous blood sampling;Very Low Birth Weight Infant;Virulence;Work

PROJECT_TITLE: Enteral Iron Supplementation and Intestinal Health in Preterm Infants

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PHR: NARRATIVE Even though strong scientific evidence shows that self-measured blood pressure monitoring helps patients with hypertension control their blood pressure, less than 1 in 5 hypertensive patients in the United States routinely measure their blood pressure at home, and more than 40% have uncontrolled hypertension. The goal of this proposal is to apply human-centered design to refine an implementation strategy, and then implement and evaluate a telemonitoring-enabled, nurse-supported self-measured blood pressure monitoring intervention (Remote Patient Monitoring for Hypertension) in a primary care network. If successful, this project has the potential to accelerate a change in the paradigm for hypertension management from the clinic to the home.

PI_NAMEs: KRONISH, IAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acceleration;Address;Adherence;African American;Age;Ambulatory Care;American Medical Association;behavior change wheel;Blood;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure medication;Blood Pressure Monitors;budget impact;Calendar;Caring;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinic;Clinic Visits;Clinical;Clinical effectiveness;Cluster randomized trial;Code;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effective;cost effectiveness;COVID-19 pandemic;Data;design;Early Intervention;Economics;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation design;evidence based guidelines;Feedback;Fostering;Goals;Guidelines;Health Care Costs;Health system;Healthcare Systems;Heart;Heart failure;Hispanic;Hispanic Populations;Home;human centered design;Hybrids;Hypertension;hypertension control;hypertensive;implementation evaluation;implementation outcomes;implementation strategy;improved;innovation;Intervention;Interview;Knowledge;Low income;Lung;Marketing;Measurement;Measures;Medicaid;Modeling;models and simulation;Monitor;New York;New York City;Nurses;Outcome;patient engagement;Patient Monitoring;patient population;Patients;Persons;Pharmaceutical Preparations;pilot test;post implementation;pragmatic trial;Presbyterian Church;Primary Care;primary care clinic;Process;programs;Provider;Public Health;Quality-Adjusted Life Years;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Regimen;Remote management;remote patient monitoring;socioeconomics;System;systematic review;Team Nursing;Telemedicine;telemonitoring;theories;Titrations;Training;Translations;treatment as usual;trend;trial design;Uncertainty;United States;uptake;Use Effectiveness;Waiting Lists;Work

PROJECT_TITLE: Implementing Remote Patient Monitoring to Improve Hypertension Control in a Primary Care Network


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: Project Narrative - Patient Derived Cancer Model (PDCM) Finder Patient derived Cancer Models (PDCM) are developed by taking tumors out of cancer patients and processing them to create cell lines that grow in a dish, “organoids” that recreate a min-version of the tumor in culture, or patient derived xenograft mouse models where the tumor is transplanted into a mouse that lacks an immune system. All three models are used as tools to study how tumors grow and give scientists and doctors the opportunity to test new therapies. This project proposes to collect and combine data across all three model types to allow researchers to find models for their own research and to reuse existing data to enable new discoveries into tumor biology and understand why cancers develop resistance to drugs.

PI_NAMEs: PARKINSON, HELEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adoption;American Association of Cancer Research;anti-cancer research;Architecture;Area;Awareness;Cancer cell line;Cancer Center;Cancer Model;Cancer Patient;Catalogs;Cell Line;clinical decision-making;cloud based;Collaborations;Collection;Communities;Community Outreach;Data;data acquisition;Data Discovery;data ecosystem;data harmonization;data modeling;Data Set;data submission;Development;Diagnosis;Disease Progression;drug candidate;Drug Evaluation;Drug resistance;Educational workshop;Ensure;ethnic minority;Evolution;experience;FAIR principles;Feedback;Future;Growth;Human;Immune system;improved;interoperability;Investments;knowledgebase;Malignant Neoplasms;meetings;minority children;Modeling;Molecular;molecular modeling;mouse model;Mus;Mutation;NCI Thesaurus;next generation;Nomenclature;novel;novel therapeutics;Oncogenic;Ontology;Organoids;Outcome;outreach;patient derived xenograft model;patient population;Patients;Pharmaceutical Preparations;Pharmacogenomics;prevent;Publications;repository;Research;Research Personnel;Resistance development;Resource Development;Resources;response;Scientist;screening;Semantics;Services;social media;Surveys;Testing;The Jackson Laboratory;tool;Training;Transplantation;tumor;Tumor Biology;tumor xenograft;Visualization software;Work;Xenograft Model