NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease and related dementias (AD/ADRD), are among the fastest growing diseases afflicting millions of people worldwide with tremendous economic and societal burdens. A highly conserved and less understood family of human Tubulin Polymerization Promoting Proteins (TPPP) is implicated in PD and related disorders. Using a model system and postmortem human brains of healthy individuals and PD patients, this proposal seeks to elucidate novel mitochondrial mechanisms underlying TPPP functions in promoting neuronal survival and gain insights into disease pathogenesis.

PI_NAMEs: BANERJEE, SWATI  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Adult;Affect;Age;Alzheimer's disease related dementia;Autopsy;Behavioral;Biochemical;Bioenergetics;Biological;Biological Assay;Biological Models;Brain;Brain region;brain tissue;Carrier Proteins;Cells;Characteristics;Citric Acid Cycle;Co-Immunoprecipitations;Complex;Crista ampullaris;Cytoplasm;Data;Data Analyses;density;design;disability;Disease;dopaminergic neuron;Drosophila genus;Economics;effective therapy;Electron Transport;experimental study;Family;fly;Fractionation;Functional disorder;Funding;Future;gel electrophoresis;Genes;Genetic;genetic approach;genomic locus;Health;Healthcare;Homologous Gene;Human;in vivo;Individual;Inner mitochondrial membrane;insight;iodixanol;knock-down;Knowledge;Lewy Body Dementia;liquid chromatography mass spectrometry;Mass Spectrum Analysis;member;Membrane Potentials;Methodology;Methods;Mitochondria;mitochondrial membrane;Modeling;Molecular;Morphology;Multiple System Atrophy;mutant;Mutation;Names;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;novel;Outcomes Research;overexpression;Parietal Lobe;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Patients;Persons;pharmacologic;Phenocopy;polymerization;Polymers;Preparation;prevent;programs;progressive neurodegeneration;protein aggregation;protein function;Proteins;Proteomics;Research;risk variant;Role;sex;solute;Spirometry;Substantia nigra structure;Superoxides;synucleinopathy;System;Techniques;Testing;therapeutic target;Time;Tubulin;Western Blotting

PROJECT_TITLE: Molecular Mechanisms of Tubulin Polymerization Promoting Protein in Mitochondrial Function and Neuronal Survival

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: FAMILY MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Our scientific premise leverages minority stress theory and builds on literature that indicates that: a) sexual minority (SM) versus heterosexual young adults (YAs) display higher rates of tobacco use initiation, current use, and escalations in use along with fewer successful quit attempts; b) SMYAs experience minority stress, including mental health problems, family stress, less peer support, and discrimination; c) SMYAs residing in rural (vs. urban) areas may be especially vulnerable to experiencing minority stress due to greater community- based stigma toward SM individuals; and d) rural individuals face higher tobacco use rates and related mortality. The overall goal of this research is to address knowledge gaps in prevention and cessation efforts targeting SMYAs, by examining minority stress factors (i.e., mental health problems, family stress, less peer support, discrimination) as mediators of the associations between rural versus urban status and tobacco use outcomes (i.e., any current use, specific product use, changes in use status/level) among SMYAs over time via longitudinal survey assessments and in real time via ecological momentary assessments.

PI_NAMEs: ROMM, KATELYN  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Adult;Age;analytical method;Area;behavior change;Cigar;Cigarette;cigarette smoking;Communities;coping;Coupled;Data;Development;Discrimination;Disease;Disparate;Disparity;disparity reduction;Ecological momentary assessment;Electronic cigarette;Environment;Exhibits;experience;Face;Family;Foundations;gender minority group;General Population;Goals;Heterosexuals;hookah;improved;insight;Knowledge;Lesbian Gay Bisexual;Life Experience;Literature;Longitudinal Surveys;Mediator;Mental Health;Methods;minority stress;minority stressor;mortality;National Institute of Drug Abuse;Nicotine;Nicotine Dependence;non-heterosexual;novel;Outcome;pansexual;peer support;Population;Predisposition;Prevention;queer;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk;Rural;rural area;Rural Minority;Rural Population;rural residence;rurality;Sex Orientation;sexual minority;sexual minority disparity;sexual minority group;sexual minority health;Smokeless Tobacco;social media;social stigma;Stress;stressor;Surveys;theories;Time;Tobacco;tobacco advertising;tobacco prevention;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco user;tobacco-free;urban area;urban residence;Work;young adult

PROJECT_TITLE: Elucidating minority stress influences on tobacco use at the intersection of sexual orientation and rurality

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative IRAK1 kinase is a core transducer of Toll-like receptor (TLR)-mediated innate immunity in vertebrates, with no reported role outside of the pathogen response. We recently identified IRAK1 as essential for cell survival in response to ionizing radiation (gIR), acting in a pathway distinct from TLR signaling. We will elucidate the spatiotemporal dynamics and molecular mechanisms of IRAK1 activation after gIR, as well as illuminate its biologic role.

PI_NAMEs: SIDI, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Adaptor Signaling Protein;Address;Animals;Apoptosis;Apoptotic;Binding;Biological;biological adaptation to stress;Biological Markers;Biological Process;Cancer Patient;Cell Nucleolus;Cell Nucleus;cell suicide;Cell surface;Cell Survival;Cells;Complex;Cytoplasm;DAP kinase;Data;Death Domain;Detection;determinants of treatment resistance;diagnostic tool;Dimerization;Dissociation;DNA;DNA Damage;DNA Double Strand Break;Dose;Drosophila genus;Environment;extracellular;fly;Genetic Screening;genotoxicity;Germ Cells;Hand;Human;IL1R1 gene;Immune signaling;Immunity;improved outcome;Induction of Apoptosis;Infection;Inflammatory;interleukin-1 receptor-associated kinase;Intrinsic drive;Ionizing radiation;IRAK1 gene;IRAK4 gene;lead candidate;Ligation;Link;lymphoblast;Malignant Neoplasms;Mammals;Mediating;Meiotic Recombination;member;microbial;micronucleus;Modeling;Molecular;Mus;MyD88 protein;Natural Immunity;new therapeutic target;NF-kappa B;novel;Nuclear Envelope;Nuclear Import;Nuclear Translocation;pathogen;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Preparation;pressure;prevent;Process;Protein Kinase;Proteins;Radiation therapy;Receptor Signaling;recruit;Reporting;Resistance;response;Role;Rupture;sensor;Signal Pathway;Signal Transduction;Sister;spatiotemporal;Stimulus;stressor;Tertiary Protein Structure;Toll-like receptors;TRAF6 gene;Transducers;Travel;tumor;ubiquitin-protein ligase;Ubiquitination;Ultraviolet Rays;V(D)J Recombination;Vertebral column;Vertebrates;Work;Zebrafish

PROJECT_TITLE: A Non-Canonical IRAK1 Signaling Pathway Triggered by Ionizing Radiation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: COLUMBIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: The enzymes of the proline cycle are central to the metabolic shift that occurs in cancer cells to enable tumorigenesis and metastasis. This project will develop chemical probes of proline cycle enzymes and use them to discover novel cellular mechanisms of proline metabolism in cancer. The proposed research is a key initial step in establishing the tractability of the proline cycle as a therapeutic target.

PI_NAMEs: BECKER, DONALD F;TANNER, JOHN J (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Abbreviations;Address;Affinity;Anabolism;analog;Animal Cancer Model;Animals;Antineoplastic Agents;Autophagocytosis;Award;Binding;Binding Sites;Biochemical;blind;Breast Cancer Cell;cancer cell;carboxylate;Catabolism;Cell Death;cell growth;cell growth regulation;Cell model;Cell Physiology;Cell Survival;cell type;Cells;Cellular Assay;Cellular biology;Cellular Metabolic Process;Cessation of life;Chemicals;cheminformatics;Coenzymes;cofactor;Collaborations;Complex;Cytosol;Data;Databases;design;Development;Docking;Drug Targeting;Electron Transport;Elements;endoplasmic reticulum stress;Enzymatic Biochemistry;enzyme biosynthesis;Enzyme Inhibition;Enzyme Kinetics;Enzymes;Generations;Goals;Growth;Homeostasis;improved;inhibitor;insight;Kinetics;Knowledge;Libraries;Ligands;macromolecule;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modification;Neoplasm Metastasis;novel;novel therapeutic intervention;oxidation;Oxidation-Reduction;Pathway interactions;Pharmaceutical Chemistry;Phase;Play;Production;Productivity;Proliferating;Proline;Proline Dehydrogenase;Protein Dynamics;Protein Isoforms;Proteins;pyrroline;pyrroline 5 carboxylate reductase;Reaction;Recombinants;Request for Applications;Research;Resolution;Role;screening;Signal Transduction;Site;small molecule;Source;Specificity;Stress;structural biology;Structure;Supporting Cell;targeted cancer therapy;targeted treatment;Therapeutic Intervention;therapeutic target;Time;tumor metabolism;tumor progression;tumorigenesis;virtual;X-Ray Crystallography

PROJECT_TITLE: Investigating the Proline Cycle as a Potential Cancer Therapy Target

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Headaches;Migraine;Neurosciences;Pain Research;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Adolescents with migraine experience changes in their migraine symptoms during puberty, however, the mechanisms through which such changes occur remain unclear and individuals who will experience worsening, no change, or improvement of their symptoms cannot be identified. This goal of this study is to identify the baseline factors that determine migraine prognosis and characterize the changes in these factors preceding or following changes in migraine symptoms in adolescents. The results of this study will address an important knowledge gap concerning adolescent migraine and will enable the development of novel early- preventive strategies or personalized medical interventions for migraine.

PI_NAMEs: NAHMAN-AVERBUCH, HADAS  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Adolescent;Affect;Age;Amygdaloid structure;Behavior Therapy;Blood;boys;Caring;Categories;Child;chronic pain;Clinic;conditioned pain modulation;Control Groups;Data;Development;Diagnosis;Disabling;Disease;experience;Female;follow-up;Follow-Up Studies;Frequencies;functional MRI scan;girls;Goals;Gonadal Steroid Hormones;Headache;high risk;Hormonal;Hormones;improved;Individual;Intervention;Knowledge;male;Measures;Medical;Migraine;Migraine disability;migraine treatment;Modeling;neural;novel;Outcome;pain symptom;Participant;Patients;pediatric patients;personalized medicine;Prefrontal Cortex;Prevention;Prevention strategy;Preventive treatment;Procedures;Prognosis;Psychophysics;Puberty;recruit;response;Risk;sex;Specialist;Surveys;symptomatic improvement;Symptoms;Testosterone;Visit

PROJECT_TITLE: Migraine Prognosis in Adolescents

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The proposed project is relevant to public health because understanding how forebrain circuits enable behavioral sequences will help to illuminate the processes underlying the acquisition and performance of skilled movements. Thus, this research is relevant to the NIH’s mission to contribute to the body of knowledge needed to develop novel therapies for treating those who experience motor disorders.

PI_NAMEs: LONG, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;Anatomy;Behavior;behavior measurement;Behavioral;bird song;Brain;Brain Diseases;Brain region;Categories;Cell Nucleus;cell type;Cells;Complex;Courtship;Dedications;Dendrites;Disease;Electron Microscopy;Elements;Exhibits;experience;extracellular;Family;Generations;Glutamates;Goals;Health;Hybrids;Image;in vivo;Individual;Interneurons;Knowledge;Laboratories;Lesion;Measures;Mediating;Mission;Molecular;Motor;motor disorder;motor learning;Motor Neurons;Motor Skills;Movement;Names;neural;neural circuit;neuromechanism;Neurons;novel;novel therapeutics;optogenetics;Pathway interactions;Pattern;Performance;Play;Population;postsynaptic neurons;Process;Production;Property;Prosencephalon;Public Health;Research;response;Role;sequence learning;Shapes;skills;Source;Stream;Structure;Synapses;Tennis;Testing;Thalamic Nuclei;Thalamic structure;tool;Training;United States National Institutes of Health;Viral;vocalization;voltage clamp;Work;zebra finch

PROJECT_TITLE: Synaptic and circuit mechanisms of learned motor sequences

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Schizophrenia is a common and debilitating mental illness with relatively unknown etiology or pathophysiology. We are proposing to identify pathophysiology by studying neurons derived from schizophrenia patient and control induced pluripotent stem cells. Electrophysiology, cell biology, imaging, and molecular analyses will be applied to these models to discover pathophysiology associated with specific clinical and cognitive symptomatology unique to each individual patient with the goal of developing new therapeutic treatments.

PI_NAMEs: MAHER, BRADY J (contact);STRAUB, RICHARD ERIC

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Adult;Architecture;Behavior;Biological Assay;Biological Models;Biology;blind;Cell Line;Cell model;cell type;Cells;Cellular biology;Characteristics;Clinical;clinical phenotype;Cognition;Cognitive;Cognitive deficits;cognitive performance;cohort;comparison control;Complement;Complex;Data;design;Development;Diagnosis;Disease;Electrophysiology (science);Etiology;Exhibits;experimental study;Fibroblasts;Functional disorder;gamma-Aminobutyric Acid;Generations;Genes;Genetic;Genetic Risk;Genome;Genomics;Goals;hippocampal pyramidal neuron;Human;human induced pluripotent stem cells;Image;Immunohistochemistry;Impairment;improved;In Vitro;in vitro Model;Individual;individual patient;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;induced pluripotent stem cell technology;inhibitory neuron;Link;Measures;Mental disorders;metabolomics;Modeling;Molecular;Molecular Analysis;multimodal data;multimodality;National Institute of Mental Health;Nature;Neurons;new therapeutic target;novel;novel therapeutics;Organoids;Outcome;Patient Selection;patient subsets;Patients;Performance;Pharmacology;Phenotype;Physiological;polygenic risk score;predictive marker;Property;Proteomics;Protocols documentation;Psychiatry;Publishing;Ramp;Reporting;response;risk variant;Sample Size;Sampling;Schizophrenia;schizophrenia risk;segregation;Severities;Siblings;single-cell RNA sequencing;Sodium Channel;Sorting;symptomatology;Symptoms;Synaptic Transmission;Testing;therapeutic target;transcriptome sequencing;transcriptomics;transmission process;voltage;Wisconsin;Work

PROJECT_TITLE: Understanding Schizophrenia Risk Mechanisms Via Multimodal Analysis of Patient-derived Neurons and 3D Cortical Organoids and Correlation with Clinical and Cognitive Phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Kidney Disease;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Human lupus nephritis is a common severe manifestation of systemic lupus erythematosus that is often unresponsive to conventional therapies. We propose to identify and quantify the immune states within the kidney that predict progressive renal damage. We will then use similar and complementary techniques to identify which mouse models of lupus nephritis manifest specific human pathogenic mechanisms.

PI_NAMEs: CLARK, MARCUS RAMSAY (contact);CRAFT, JOSEPH EDGAR;DAVIDSON, ANNE

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: adaptive immunity;Address;Affect;aggressive therapy;Antibody Repertoire;Antigen-Antibody Complex;Antigen-Presenting Cells;Architecture;Area;Artificial Intelligence;Autoimmune;Autoimmunity;B-Lymphocytes;Biopsy;Blood capillaries;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Aggregation;Cells;Cicatrix;Clinical;clinical predictors;Clinical Trials;Clonal Expansion;Complex;computerized tools;Confocal Microscopy;conventional therapy;Cyclophosphamide;Data;Deposition;Diagnosis;Disease;disease model;Disease Progression;Disease remission;drug development;End stage renal failure;experimental study;Failure;Fibrosis;Gender;Glomerulonephritis;Heterogeneity;high dimensionality;Histologic;Human;human disease;human RNA sequencing;Hypoxia;Image;Immune;immune cell infiltrate;Immunity;Immunologics;In Situ;Inflammation;Inflammatory;innovation;interstitial;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Lead;Link;Lupus;Lupus Nephritis;Metabolic dysfunction;Modeling;mortality;mouse model;Mus;mycophenolate mofetil;Myelogenous;Myeloid Cells;Natural Immunity;Neighborhoods;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;Phenotype;Population;pre-clinical;predicting response;Prognosis;prognostic;Publishing;renal damage;response;single-cell RNA sequencing;Site;Structure;Structure of germinal center of lymph node;Systemic Lupus Erythematosus;T cell infiltration;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Therapeutic immunosuppression;Therapeutic Intervention;therapy resistant;tissue injury;Tissues;Treatment Efficacy;Work

PROJECT_TITLE: Using artificial intelligence to bridge human and murine studies of lupus nephritis progression

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative (Public Health Relevance Statement)  Asthma is a chronic inflammatory disease of the airways characterized by lung inflammation that results in bronchoconstriction and thickened airway walls, ultimately causing difficulty in breathing. We propose to study the role of an enzyme known as Diacylglycerol Kinase in regulating constrictor and proliferative functions of airway smooth muscle cells and the inflammatory response of immune cells with an overarching goal of establishing these enzymes as novel therapeutic targets in managing asthma.

PI_NAMEs: DESHPANDE, DEEPAK A (contact);KAMBAYASHI, TAKU

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Ablation;Acetylcholine;Affect;Airway Disease;airway hyperresponsiveness;airway inflammation;airway remodeling;Allergens;Allergic inflammation;antagonist;Asthma;asthma model;asthmatic airway;Attenuated;Biochemical;Biological Assay;Breathing;Bronchoconstriction;Calcium;cell mediated immune response;Cell Physiology;Cell Proliferation;Cell surface;Cells;chronic inflammatory disease;Clinical effectiveness;Complex;Coupled;cysteinyl leukotriene receptor;Data;Development;Diacylglycerol Kinase;Diglycerides;Disease;drug discovery;Drug Targeting;efficacy testing;Enzymes;Equilibrium;experimental study;extracellular;Extracellular Matrix;Extrinsic asthma;Family;Fluorescence;Future;G-Protein-Coupled Receptors;Generations;Genetic;Goals;Grant;Health;Human;Immune;Immune response;immunoregulation;Inflammation;Inflammatory Response;Inositol;Intranasal Administration;kinase inhibitor;Kinetics;Knockout Mice;lipidomics;Lipids;Lung;Mediating;microscopic imaging;Mitogens;Modeling;Molecular;mouse model;multimodality;Mus;Muscarinics;Muscle Contraction;Muscle function;Myosin Light Chains;new therapeutic target;novel;Nucleotides;obstructive airway disease;Outcome;Pathway interactions;Persons;pharmacologic;Phosphatidic Acid;Phosphatidylinositol 4,5-Diphosphate;Phospholipase C;Phospholipids;phosphoproteomics;Phosphorylation;prevent;Process;Proliferating;protein activation;Protein Isoforms;Protein Kinase C;Proteins;Proto-Oncogene Proteins c-akt;public health relevance;Pulmonary Inflammation;Pyroglyphidae;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Regulation;Regulatory Pathway;respiratory smooth muscle;response;Role;Second Messenger Systems;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;single molecule;Slice;small molecule inhibitor;Smooth Muscle;Smooth Muscle Myocytes;Spatial Distribution;spatiotemporal;Specific qualifier value;stoichiometry;synergism;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;tool;Treatment Efficacy;tripolyphosphate

PROJECT_TITLE: Diacylglycerol kinase in airway smooth muscle functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-H (03)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative The goal of this project is to identify the neuronal ensembles of the voluntary induction and maintenance of alcohol dependence using single-cell whole-brain functional connectomics. We will identify the role of CRF and dynorphin neurons in the whole-brain networks during intoxication, withdrawal, abstinence, and stress-induced relapse. We will also identify the brain networks modulated by pharmacological treatments known to affect alcohol-related behaviors and identify the brain networks that are specific to high-intensity binging.

PI_NAMEs: GEORGE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;acamprosate;Acute;addiction;Affect;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Amygdaloid structure;Animals;antagonist;Atlases;behavior prediction;Blood alcohol level measurement;Brain;Brain imaging;Brain region;Cell Nucleus;Cells;Corticotropin-Releasing Hormone;Disulfiram;Drug Addiction;Dynorphins;Ethanol;Exhibits;FDA approved;Funding;Goals;graph theory;Individual;innovation;interest;Intoxication;Knowledge;Label;Maintenance;Modeling;Modernization;Molecular;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;neuroadaptation;Neurons;novel;Outcome;Pathway interactions;Pattern;Pharmacological Treatment;Pharmacotherapy;Phase;Phenotype;pre-clinical;Property;Rat Transgene;Rattus;recruit;Relapse;Research;Role;Self Administration;Stress;Testing;theories;Therapeutic Effect;trend;vapor;Withdrawal

PROJECT_TITLE: Alcohol Vapor Self-Administration in Rats

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Inherited retinal diseases cause a substantial burden for affected patients and our society. Accomplishments of the proposed studies will provide pivotal insight into the molecular mechanisms of inherited retinal diseases, including congenital eye abnormalities and retinal diseases associated with non- coding SNPs, facilitating therapeutic interventions.

PI_NAMEs: LIU, WEI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Anophthalmos;Binding;Binding Sites;Biological Assay;Cell Differentiation process;Cells;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Coloboma;Comparative Study;Competence;Complex;Defect;Development;DNA;DNA Binding;DNA Sequence;Elements;EMSA;Enhancers;Epigenetic Process;Eye;Eye Abnormalities;Family;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Goals;histone acetyltransferase;Histone Deacetylase;histone modification;Histones;homeodomain;Human;Immunoprecipitation;Inherited;insight;joint function;Knowledge;loss of function;Mass Spectrum Analysis;Microphthalmos;Molecular;Muller's cell;multiple omics;Mus;mutant;Mutation;Nucleosomes;Organoids;Patients;Positioning Attribute;Post-Translational Protein Processing;programs;protein complex;protein protein interaction;Proteins;recruit;Regulation;Reporter;Repression;Resolution;Resources;Retina;Retinal Diseases;retinal neuron;retinal progenitor cell;scaffold;single cell ATAC-seq;single-cell RNA sequencing;Six3 protein;Societies;spatiotemporal;Specificity;SWI/SNF Family Complex;Testing;Therapeutic Intervention;transcription factor;Untranslated RNA;Work

PROJECT_TITLE: Gene regulation of retinal cell differentiation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NORFOLK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The molecular basis of BPH initiation and progression remains unclear, impeding advancements in treatment strategies. Our multidisciplinary approach aims to unravel whether lipid accumulation and foamy macrophages drive BPH pathology and urinary symptoms. The results of our study will identify new molecular and cellular targets paving the way for novel therapeutic approaches for this condition.

PI_NAMEs: POPOVICS, PETRA  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;aged;Aging;angiogenesis;aptamer;attenuation;Benign;Benign Prostatic Hypertrophy;candidate identification;cellular targeting;chemokine;Chemotactic Factors;Clinical;Clinical Pathology;cytokine;Data;density;Deterioration;Development;disease diagnosis;effective intervention;Ensure;Environment;Epithelium;Etiology;Exhibits;Failure;Fatty Acids;Fibrosis;Foam Cells;Foamy Macrophage;Functional disorder;gene synthesis;Genes;Genetic Models;genetic signature;Growth Factor;Histologic;Histology;Hormone imbalance;Human;Immune;Immunology;improved;Infiltration;Inflammation;Inflammatory;innovation;interdisciplinary approach;Investigation;Knockout Mice;laser capture microdissection;Life Expectancy;Lipid Synthesis Pathway;Lipids;lower urinary tract symptoms;Macrophage;male;Mediator;Medical;men;MME gene;Modeling;Molecular;Molecular Target;Monitor;monocyte;mouse model;Mus;neutralizing antibody;novel;novel marker;novel therapeutic intervention;osteopontin;Outcomes Research;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient population;Patient-Focused Outcomes;Pattern;Pharmacological Treatment;Population;Process;Proliferating;Prostate;Prostatic;Prostatic Diseases;Proteomics;Quality of life;Recombinants;Research;Research Project Grants;response;Role;Secondary to;Signal Transduction;Smooth Muscle;Specimen;steroid hormone;Symptoms;Testing;Tetracyclines;Therapeutic;therapeutic target;Time;transcriptomics;treatment strategy;Up-Regulation;Urethra;urinary;Urology;VEGFA gene

PROJECT_TITLE: Identifying the role of lipid accumulation and foam cells in benign prostate disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PATHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: The proposed research is relevant to human health because it can directly benefit a group of cancer patients that currently have extremely poor prognosis by providing them with targeted treatment options that overcome chemotherapy resistance. Through development and testing of innovative research strategies with in vitro and in vivo models, these studies are directly in line with the mission of the National Institutes of Health; seek fundamental knowledge about living systems and apply that knowledge to enhance human health.

PI_NAMEs: HARRELL, JOSHUA (CHUCK)  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: advanced disease;Apoptosis;Apoptotic;Biological;Breast Cancer Cell;Bypass;cancer cell;Cancer Patient;Carboplatin;Cells;Cellular Stress;Cessation of life;Characteristics;Chemoresistance;Clinic;Clinical;Combined Modality Therapy;compare effectiveness;cytotoxic;cytotoxicity;Data Set;Development;Disease;Disease Management;Drug Combinations;efficacy evaluation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Estrogens;FDA approved;Genes;Genetic;Genomics;Goals;Growth;Health;Human;In Vitro;in vivo Model;Individual;inhibitor;innovation;Interferometry;Knowledge;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediator;Metastatic breast cancer;Mission;Modeling;molecular drug target;Neoplasm Metastasis;new therapeutic target;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organism;Outcome;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;pharmacologic;Prognosis;Proliferating;Proteomics;Receptor Inhibition;Research;Research Proposals;Resistance;response;safety testing;Sampling;Signal Pathway;Signal Transduction;Speed;spheroids;targeted treatment;Testing;Therapeutic;transcriptome sequencing;Translating;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;United States;United States National Institutes of Health;Unresectable;Work

PROJECT_TITLE: Circumventing acquired carboplatin resistance in triple-negative breast cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative This project is to develop a novel imaging technology that combines a compact PET device with any clinical ultrasound scanner to enable real-time visualization of molecularly targeting agents in a patient. It offers interactive PET scanning capability and adds molecular contrast to ultrasound scanners while scanning a patient freehand. This enabling technology will change the status quo and bring novel molecular imaging and interventional applications to many point-of-care settings such as operating room, emergency room or patient bedside.

PI_NAMEs: TAI, YUAN-CHUAN  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Accident and Emergency department;Adopted;anatomic imaging;arm;attenuation;Biopsy;Blood flow;chemotherapy;Clinical;Companions;cost;design;detector;Development;Devices;Diagnosis;Disease;Doppler Ultrasound;druggable target;Event;Future;Genotype;Geometry;human imaging;Hybrids;Image;image guided;Image Guided Biopsy;image guided intervention;image reconstruction;imager;imaging agent;imaging capabilities;Imaging Device;imaging study;Imaging technology;improved;innovation;interest;Intervention;invention;Lesion;Machine Learning;Modeling;Molecular;molecular imaging;molecular phenotype;Molecular Target;Monte Carlo Method;Motion;Motivation;novel;novel diagnostics;novel imaging technology;Operating Rooms;Organ;Outcome;partial response;patient tolerability;Patients;Performance;Physics;Physiological;point of care;Positron-Emission Tomography;precision medicine;prototype;Radionuclide therapy;Radiopharmaceuticals;reconstruction;recruit;Regimen;Resolution;response;Robotics;Safety;Scanning;Signal Transduction;Speed;standard of care;System;targeted agent;targeted imaging;Techniques;Technology;technology development;theranostics;Therapeutic;Time;time use;Tissue Sample;Tissues;Tracer;treatment optimization;tumor;Ultrasonography;ultrasound;Update;usability;Validation;visual feedback;Visualization;volunteer;X-Ray Computed Tomography

PROJECT_TITLE: Development of a real-time interactive PET/US imaging technology to enhance theranostics applications in precision medicine

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Currently, there is no treatment for CCHF, a potentially fatal viral hemorrhagic fever disease. The ultimate goal of this project is isolate and make antibodies against this virus by studying the antibody response from survivors of this disease. We will test the antibodies in a mouse model in the hope that these antibodies can eventually be used to treat CCHF infection in humans.

PI_NAMEs: SAJADI, MOHAMMAD MOHSENI (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: 2019-nCoV;Africa;Antibodies;Antibody Response;Antigens;Arenavirus;Asia;Autoimmune;Awareness;Blood specimen;Blood Tests;Case Fatality Rates;Clinic;Clinical;cohort;Complex;Country;COVID-19;Crimean Hemorrhagic Fever;Cryoelectron Microscopy;Data;Disease;Ebola;efficacy testing;Epitope Mapping;Epitopes;Europe;experience;Glycoproteins;Goals;Grant;HIV;Human;human monoclonal antibodies;IFNAR1 gene;improved;In Vitro;in vivo;Incidence;Individual;Infection;Infectious Agent;Inflammatory;Location;Marburgvirus;Meleagris gallopavo;Methods;Monoclonal Antibodies;mortality;mouse model;Mus;neglect;neutralizing antibody;Patients;Positioning Attribute;Preclinical Testing;prevent;Prevention;Reporting;Research;research clinical testing;response;screening;Spain;Specificity;success;Survivors;Testing;tick-borne;tool;Vaccine Design;Vaccines;Viral Hemorrhagic Fevers;Viremia;Virus;World Health Organization;X-Ray Crystallography

PROJECT_TITLE: Isolation of broadly protective monoclonal antibodies for Crimean Congo Hemorrhagic Fever

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Cardiac rehabilitation (CR) is an effective evidence-based intervention that improves event-free survival in cardiac patients through continued program participation, but fewer than 10% of all eligible patients who receive CR (<30%) in the United States attend all prescribed CR sessions, with even lower rates observed among racial and ethnic minoritized groups. A hybrid CR intervention that combines optimal features of telehealth, home-, and clinic-based CR (i.e., TeleheartCR) could increase CR participation by addressing structural barriers to access, while retaining the functional capacity benefits for which CR is known. The goal of this proposal is to conduct a randomized controlled trial comparing TeleheartCR with traditional clinic-based CR in a diverse group of cardiac patients to test differences in (1) program adherence (% of total sessions completed), and (2) pre-to-post program change in functional capacity.

PI_NAMEs: DURAN, ANDREA T (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Activities of Daily Living;acute coronary syndrome;Address;Adherence;arm;Behavior Therapy;behavioral cardiology;Cardiac;Cardiac rehabilitation;Classification;Clinic;Clinical;comparative;cost;Cost Analysis;cost effectiveness;Data;data integration;design;digital;Disease-Free Survival;Disparate;Disparity;disparity reduction;Dose;Effectiveness;effectiveness/implementation hybrid;Electronic Health Record;Eligibility Determination;Enrollment;Equity;ethnic minority population;Ethnic Origin;Ethnic Population;Event;evidence base;Evidence based intervention;Evidence based practice;exercise training;experience;feasibility testing;Formulation;functional outcomes;functional status;future implementation;Goals;Guidelines;Health behavior;health care availability;health care disparity;health equity;health related quality of life;Healthcare Systems;high risk;Home;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation science;improved;indexing;Individual;Infarction;innovation;Intervention;Kinesiology;Language;Level of Evidence;literacy;low socioeconomic status;Lung;Methods;Minority Groups;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;New York;novel;Outcome;Participant;Patient Education;patient engagement;Patient Participation;Patient Self-Report;patient-level barriers;Patients;Persons;Physical activity;Population;post intervention;Presbyterian Church;Prevention program;primary outcome;Process;Program Acceptability;programs;Provider;provider-level barriers;Race;racial minority population;racial population;Randomized;Randomized, Controlled Trials;real time monitoring;Recommendation;Recurrence;remote health care;Reporting;response;Risk;Safety;Schedule;secondary outcome;Secondary Prevention;sedentary;Service delivery model;Services;Single-Blind Study;Site;Socioeconomic Status;socioeconomics;statistics;Subgroup;Supervision;Survivors;system-level barriers;Technology;telehealth;Telemedicine;Testing;Time;tool;treatment as usual;trial comparing;United States;Unstable angina;user centered design;virtual;Walking

PROJECT_TITLE: Comparing a Novel Telehealth-enabled Hybrid Cardiac Rehabilitation Program to Clinic-based Cardiac Rehabilitation for Improving Patient Engagement, Functional Outcomes, and Health Equity after ACS

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative CHD2 has been identified as a significant risk factor for neurodevelopmental disorders, including Autism Spectrum Disorder (ASD), epilepsy, Intellectual Disability (ID), and Attention-Deficit Hyperactivity Disorder (ADHD). As a chromatin remodeling protein, CHD2 regulates the expression of numerous downstream target genes, but the way in which various signaling pathways controlled by CHD2 converge and integrate functionally at the molecular and cellular levels in the nervous system remains largely unknown. We will systematically investigate how these signaling pathways interact during synaptic homeostatic plasticity and how distinct CHD2 disease risk variants impact synaptic function.

PI_NAMEs: WANG, TINGTING  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acute;Affect;Alleles;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavioral impairment;Brain;Calcium;Calcium Channel;Cell Adhesion;Cell Differentiation process;cell type;CHD1 gene;Chemosensitization;Chromatin;chromatin remodeling;Chronic;Chronic Disease;Code;Collection;Communication;comorbidity;Computer Analysis;Computing Methodologies;CRISPR/Cas technology;de novo mutation;Development;disability risk;Disease;disorder risk;DNA-Binding Proteins;Drosophila genus;electrical property;Electrophysiology (science);Epigenetic Process;Epilepsy;Etiology;Exhibits;Extracellular Matrix;falls;fly;Genes;Genetic;Genetic Screening;Genetic study;Genetic Transcription;genome editing;Glutamate Receptor;Goals;Growth;helicase;Homeostasis;Homologous Gene;Human;human disease;Human Genetics;individuals with autism spectrum disorder;insight;Intellectual functioning disability;Intellectual impairment;intercellular communication;Investigation;Knock-in;Knowledge;Life;Link;Maintenance;Maps;Methods;Molecular;Muscle;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;neural network;Neurodevelopmental Disorder;Neuroglia;Neuromuscular Junction;Neurons;neurotransmitter release;Output;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;Play;postsynaptic;Predisposition;preservation;presynaptic;presynaptic neurons;Proteins;receptor;Reproducibility;Research;Risk Factors;risk variant;Role;Schizophrenia;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;superresolution imaging;Synapses;synaptic function;Synaptic Vesicles;System;Technology;tool;transcriptomics;treatment strategy;Variant

PROJECT_TITLE: Functional Mapping of Chd1-dependent Signaling Network in Synaptic Homeostasis

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The nuclear envelope protects the nuclear environment to maintain genome integrity. The proposed work will determine how distinct regulation of bilayer lipid composition controls the formation of the nuclear envelope to protect the genome. Defining the role of membrane lipid composition in nuclear envelope formation has the potential to significantly contribute to our understanding of how defects in nuclear envelope integrity arise in human genetic disorders and cancer.

PI_NAMEs: BAHMANYAR, SHIRIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3-Dimensional;Acute;age acceleration;Amino Acids;Binding;Binding Proteins;Biological Assay;biophysical properties;Biosensor;Cell Nucleus;Cells;Chromosome Segregation;Code;Data;Defect;Diglycerides;Disease;Endoplasmic Reticulum;env Gene Products;Environment;Enzymes;experimental study;follow-up;Funding;Genetic Diseases;Genome;genome integrity;Growth;Head;Human;human disease;Human Genetics;Human Pathology;Image;In Vitro;in vivo;Integral Membrane Protein;Lead;Lipid Bilayers;Lipid Binding;Lipid Chemistry;lipid metabolism;lipidomics;Lipids;lipine;Lipodystrophy;Liposomes;Malignant Neoplasms;Membrane;membrane biogenesis;Membrane Lipids;Metabolic;Mitosis;Mitotic;Molecular;Muscle;Muscular Dystrophies;Mutation;Mutation Analysis;nanoscale;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Organelles;Pathway interactions;Pattern;Phosphatidate Phosphatase;Process;Progeria;Protein phosphatase;Proteins;Regulation;Resolution;Role;screening;seal;Site;Specific qualifier value;Structure;superresolution imaging;Testing;tissue/cell culture;tool;Work;Yeasts

PROJECT_TITLE: Defining the role of lipid metabolism in nuclear envelope identity and dynamics

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Chimeric antigen receptor (CAR) T cell immunotherapy is a powerful treatment for hematologic malignancies, however clinical responses vary depending on CAR T cell function and persistence. The optimization of CAR design has gained considerable interest with a new focus on calibrating CAR intracellular signals via the immunoreceptor tyrosine-based activation motifs (ITAMs) to increase fitness of CAR T cells. In this proposal we will test the hypothesis that finetuning the combination of ITAM sequences of the CD3 zeta ITAM alters the kinetics of kinase and adaptor molecule recruitment, influencing bond lifetime and the quality of intracellular signaling resulting in long-lived tumor killing T cells.

PI_NAMEs: BETTINI, MATTHEW  (contact);EVAVOLD, BRIAN D

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adoptive Transfer;Affinity;Antigen Targeting;Antigens;B lymphoid malignancy;Binding;Biology;Calibration;CD19 gene;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;cytokine;cytokine release syndrome;Cytoskeleton;Data;design;effector T cell;Epitopes;Event;Exhibits;extracellular;Failure;fighting;fitness;Generations;Goals;Grant;Hematologic Neoplasms;Human;immune activation;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;insight;interest;ITAM;Kinetics;Ligands;Malignant Neoplasms;Measures;Membrane;Memory;MHC Interaction;mouse model;Mus;mutant;neoplastic cell;neurotoxicity;novel;Patients;Peptide/MHC Complex;Peptides;Phase;Phenotype;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphotransferases;Positioning Attribute;Production;Proliferating;Proteins;Publishing;receptor;Receptor Activation;receptor function;Receptor Signaling;recruit;response;Role;Signal Pathway;Signal Transduction;Specificity;Stimulus;T memory cell;T-Cell Development;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Toxic effect;tumor;two-dimensional;Tyrosine;Work;ZAP-70 Gene

PROJECT_TITLE: The Role of CD3z ITAM (Immunoreceptor Tyrosine-Based Activation Motif) diversity in CAR T cell Force and Function

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Microbiome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Metastatic castration resistant prostate cancer (mCRPC) remains a leading cause of cancer deaths in males and there is a tremendous unmet clinical need to uncover mechanisms of therapeutic resistance in this patient population. This study will discover and validate bacterial enzymatic pathways that are responsible for androgen production in the gut that contributes to therapeutic resistance to immunotherapy and endocrine therapy in mCRPC. We ultimately aim to identify a microbiome drug target for use in the development of targeted therapeutics to overcome treatment resistance; as such, we anticipate that the knowledge gained from the proposed studies could be translated to a therapeutic that could greatly impact the lives of individuals with advanced mCRPC.

PI_NAMEs: MORAN, AMY E;RIDLON, JASON MICHAEL;SFANOS, KAREN SANDELL (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: abiraterone;Acetates;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Metabolism;Androgen Receptor;Androgen Therapy;Androgens;Antibiotic Therapy;Automobile Driving;Bacteria;Bacterial Genes;biobank;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;Castration;Cell Physiology;Cells;Cessation of life;chemotherapy;Clinical;Clinical Data;Clinical Trials;Clostridium;cohort;Combined Modality Therapy;commensal bacteria;Dependence;Development;Disease;Drug Targeting;Effectiveness;Endocrine;Engineering;enzalutamide;Enzymes;experimental study;Explosion;fecal microbiome;fecal transplantation;Female;gastrointestinal;gene discovery;Genes;Glucocorticoids;Growth;gut microbes;gut microbiome;gut microbiota;hormone therapy;Human;Human Microbiome;Immune;immune checkpoint blockade;Immune response;Immunocompetent;Immunosuppression;Immunotherapy;In Vitro;in vivo;Individual;Insulin-Dependent Diabetes Mellitus;intratumoral androgen;Knowledge;Leukocytes;Ligands;Literature;male;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;metabolome;metagenome;Metastatic Prostate Cancer;Microbe;microbial;microbiome;microbiota;mouse model;Mus;mutant;neoplastic cell;novel;oral androgen;Pathway interactions;patient population;Patients;pembrolizumab;Phenotype;Prednisone;Production;Publishing;Receptor Inhibition;Receptor Signaling;Refractory;Reporting;Resistance;response;restraint;Role;Shapes;Solid Neoplasm;Source;standard of care;Steroids;Sterols;System;targeted agent;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic target;therapy resistant;Translating;treatment response;tumor;tumor growth;Tumor Immunity;Tumor Promotion

PROJECT_TITLE: Defining the Mechanistic Basis of Bacterial Androgen Production in Dampening Anti-Tumor Immunity and Promoting Resistance to Androgen Receptor Axis-Targeted Therapies for Metastatic Prostate Cancer

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Overall – Narrative Climate change is and will remain the most significant threat to global public health; the need for robust scientific evidence to guide maximally effective and equitable action is paramount. To address this urgent need and build capacity in climate and health research, we have designed the Climate and Health: Action and Research for Transformational Change (CHART) Center. CHART’s mission and overarching aim is to launch a transformative and integrative framework for climate health research, from molecules to populations, that drives evidence-based impactful solutions.

PI_NAMEs: BERHANE, KIROS T;KIOUMOURTZOGLOU, MARIANTHI-ANNA  (contact);SHAMAN, JEFFREY L

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;atmospheric sciences;Automobile Driving;Biometry;burden of illness;Climate;climate change;climate science;climate-related health;Communication;Communities;community engagement;Complex;Creativeness;data integration;Data Science;design;Development;Discipline;Educational workshop;Engineering;Ensure;Environmental Health;Epidemiology;Equity;Event;evidence base;Fostering;Future;global health;Health;Health Professional;Human;Image;improved;innovation;Intervention;Investments;Justice;Machine Learning;marginalized community;Medicine;member;Methods;Mission;Nature;Neuropsychology;next generation;Outcome;Personal Satisfaction;Pilot Projects;Policies;Policy Maker;Population;programs;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Risk;Science;scientific atmosphere;Series;Shamanism;Shapes;shared decision making;signal processing;skills;Sociology;statistics;Toxicology;Training;translational impact;Translations;United States National Institutes of Health;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Clinical Research

PI_NAMEs: KIOUMOURTZOGLOU, MARIANTHI-ANNA  (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Aging;Award;Biology;Budgets;Climate;climate change;climate science;climate-related health;cohort;Collaborations;Communication;Communities;community engagement;Community of Practice;Creativeness;Data Analyses;data integration;Data Science;design;Doctor of Philosophy;Effectiveness;Ensure;epidemiology study;Evaluation;Event;evidence base;Fostering;Funding;General Population;Goals;Health;Heart;innovation;interdisciplinary collaboration;Leadership;longitudinal analysis;Machine Learning;Methods;Mission;Nerve Degeneration;Newsletter;Performance;Pilot Projects;Policy Maker;Population;Productivity;programs;Progress Reports;Research;Research Design;Research Personnel;Research Project Grants;Resources;Schools;Science;Scientist;Series;Shamanism;statistics;Structure;Toxicology;Training;Translational Research;Translations;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

PROJECT_TERMS: Aging;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Biological;Cardiovascular Diseases;Characteristics;Climate;climate change;climate impact;climate zone;climate-related exposures;climate-related health;cognitive function;cohort;Communities;Data;Dementia;Droughts;Equity;Event;experience;Exposure to;Floods;Foundations;Frequencies;Health;health disparity;Heat Waves;Height;High temperature of physical object;Hospitalization;Housing;Human;Hurricane;indexing;insight;interest;Intervention;Investments;Justice;Knowledge;lens;Life Expectancy;Link;machine learning algorithm;Medicare;Medicare claim;Mental Health;Methodology;Modification;mortality;Nerve Degeneration;Neurodegenerative Disorders;Outcome;Parkinson Disease;Participant;Pathway interactions;Pattern;Persons;Play;Policies;Positioning Attribute;Precipitation;Prevalence;Prospective Studies;Research;Research Project Grants;resilience;Resolution;Role;sociodemographics;spatiotemporal;Temperature;Time;Tornadoes;Variant;Visit;Washington;Wildfire

PROJECT_TITLE: Nationwide Associations between Multiple Co-Occurring Climate Threats and Neurodegeneration


PI_NAMEs: MILLER, GARY W (contact)

PROJECT_TERMS: age related;age related neurodegeneration;Age related pathologies;age-related disease;Aging;Alzheimer's Disease;animal data;behavioral outcome;Bioinformatics;Biological;Biological Markers;Biology;Biopsy;blood-brain barrier crossing;Brain;Caenorhabditis elegans;Climate;climate change;climate-related health;climatic factors;Clinical;cohort;Collaborations;Communities;Complex;Data;Disasters;Disease;disease classification;Ecosystem;Environment;Environmental Risk Factor;Event;experience;extracellular vesicles;extreme temperature;Foundations;Funding;Health;Housing;Human;Human Biology;indexing;Individual;Killifishes;Laboratories;Laboratory Animals;life span;Liquid substance;Mass Spectrum Analysis;Measures;member;metabolomics;MicroRNAs;Mission;model organism;Modeling;Morbidity - disease rate;multi-ethnic;multiple omics;National Institute of Environmental Health Sciences;Nematoda;Nerve Degeneration;network models;Neurons;New York City;Outcome;Participant;Pathway interactions;physiologic stressor;Plasma;Population;Prospective cohort;psychological stressor;Research;Research Personnel;residence;Resolution;Role;Sampling;severe weather;Signal Transduction;Source;Study Subject;System;Temperature;Testing;transcriptome sequencing;trend;Vertebrates;Weather;Work

PROJECT_TITLE: Network biology-based markers of climate-induced neurodegeneration


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: ZOTA, AMI R (contact)

PROJECT_TERMS: Advocate;authority;Awareness;Belief;Climate;climate change;climate crisis;climate data;climate impact;climate science;climate-related health;Collaborations;Communication;Communities;community collaboration;community engaged research;community engagement;community organizations;community partners;community-centered;Data Science;Data Scientist;design;Development;disadvantaged background;Doctor of Philosophy;editorial;Educational workshop;Electronic Medical Records and Genomics Network;Emotions;Ensure;environmental justice;Environmental Science;Equity;Event;evidence base;experience;Fellowship;Film;Fostering;Health;health disparity;Health education;health equity;Health Professional;Health Sciences;Health system;Healthcare;Incubated;indexing;Individual;Infrastructure;innovation;International;Joints;Justice;Knowledge;Leadership;Logic;marginalized community;member;mentoring community;Methods;National Institute of Environmental Health Sciences;New York City;Output;Pilot Projects;Policies;Policy Maker;prevent;Production;professional partner;programs;Public Health;recruit;Research;Research Personnel;Resources;Science;Scientist;Series;skills;social;social vulnerability;Societies;Strategic Planning;Technical Expertise;Techniques;Training;training data;Training Programs;Translating;Universities;Vision;Voice;vulnerable community;Writing

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Aging;Bioengineering;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: BERHANE, KIROS T (contact)

PROJECT_TERMS: Adherence;Adoption;Archives;Biology;Climate;climate change;climate data;climate science;climate variability;climate-related exposures;climate-related health;Code;Collaborations;Communication;community engagement;Community of Practice;complex data;Computer software;Data;Data Analyses;Data Analytics;Data Collection;data harmonization;data integration;data interoperability;data library;data management;data quality;Data Science;data sharing;Data Sources;data streams;Databases;design;Development;Doctor of Philosophy;educational atmosphere;Educational workshop;Electronics;Ensure;Evolution;Faculty;Feedback;Fostering;Funding;Future;Goals;Information Systems;Infrastructure;International;interoperability;Leadership;method development;Mission;Modeling;Monitor;Nerve Degeneration;Ontology;operation;Pilot Projects;Positioning Attribute;Procedures;programs;Protocols documentation;quality assurance;Quality Control;repository;Reproducibility;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resources;response;Role;Running;Science;Secure;Series;Societies;software development;Source;Specialist;Statistical Data Interpretation;Statistical Methods;Structure;Techniques;tool;Training;Training Activity;Universities;Visualization

PROJECT_TITLE: Integrated Data and Exposure Analytics (IDEA) Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Bioengineering;Biotechnology;Clinical Research;Health Effects of Indoor Air Pollution;Lung

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The proposed research will develop new statistical methods for estimating concentrations of analytes measured in immunoassays, considering measurement error and contamination in the samples, and modeling exposure-outcome associations with adjustment for exposure measure uncertainty. The proposed new methods will be developed based on the indoor allergen measures collected using ELISAs and multiplex assays in the New York City Neighborhood Asthma and Allergy Study and will be used to assess the associations between concentrations of indoor allergens and asthma morbidity among asthmatic children. The methods and tools developed in this proposal will have a wide range of applications and can be used to improve lab analyses, which are crucial for diagnosis, treatment, and intervention decisions in many areas of medicine and public health.

PI_NAMEs: CHEN, QIXUAN  (contact);GELMAN, ANDREW

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 3-Dimensional;Accounting;Allergens;Allergic;antibody and antigen binding;Area;Asthma;asthmatic;Attenuated;Bayesian Method;Biological Assay;Biological Markers;Biological Products;Biological Sciences;Calibration;Child;Clinical;clinical diagnosis;clinical diagnostics;Clinical Research;Collaborations;Data;detection limit;Diagnosis;Disease;Dust;Environmental Monitoring;Environmental Pollution;Enzyme-Linked Immunosorbent Assay;Epidemiologic Methods;Epidemiology;epidemiology study;Goals;graphical user interface;Health;Health Sciences;Hypersensitivity;Immunoassay;improved;indoor allergen;indoor concentrations;insight;Intervention;Joints;Measurement;Measures;Medicine;method development;Methods;model building;Modeling;Morbidity - disease rate;multiplex assay;Neighborhoods;new technology;New York City;Outcome;Paper;Proteins;Protocols documentation;Public Health;Pythons;Reaction;Reading;Research;Research Methodology;Research Personnel;response;Sampling;software development;Statistical Methods;System;Testing;tool;Uncertainty;uptake;user-friendly;Validation

PROJECT_TITLE: Improving the analysis and use of contaminated immunoassays: from methods development to implementation

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATVE This proposal uses state-of-the art machine learning techniques to extract important clinical information from digital kidney biopsy images. Deep learning models will integrate digital kidney pathology with proteomics and clinical data into a larger prediction framework to provide kidney disease patients with an automated assessment of vascular pathology and cardiovascular prognosis.

PI_NAMEs: SCHMIDT, INSA MARIE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Adult;Advisory Committees;Affect;Artificial Intelligence;artificial neural network;Attention;automated assessment;Biological Markers;Biometry;Biopsy;Blood Vessels;Boston;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Cessation of life;Characteristics;Chronic Kidney Failure;Classification;Clinical;Clinical Data;clinical phenotype;Clinical Research;clinically relevant;cohort;Cohort Studies;Complex;Computer Systems;Computer Vision Systems;Computers;convolutional neural network;cost;Data;Data Science;deep learning;deep learning algorithm;deep learning model;Diagnosis;Diagnostic;diagnostic accuracy;digital;digital imaging;digital pathology;Disease;Disease Progression;Disease remission;Early Diagnosis;Early treatment;Epidemiology;Evaluation;Event;experience;follow-up;Future;Glomerular Filtration Rate;Goals;Heart failure;Hematoxylin and Eosin Staining Method;Histologic;Histopathology;Hospitalization;Human;Image;improved;improved outcome;Individual;individual patient;insight;Kidney;kidney biopsy;Kidney Diseases;kidney vascular structure;Label;large datasets;Lead;Learning;Lesion;Machine Learning;Measurement;Measures;Medical center;Mentors;Mentorship;Modeling;mortality;multimodality;Myocardial Infarction;Nephrology;neural network;Neural Network Simulation;novel;novel marker;Output;Pathologic;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Pattern;Performance;Periodic acid Schiff stain method;Phenotype;Plasma Proteins;Play;Population;Positioning Attribute;precision medicine;premature;Principal Investigator;Process;Prognosis;prognostic;Prospective, cohort study;Proteins;Proteinuria;Proteomics;Protocols documentation;Public Health;Renal function;Research;Research Personnel;Risk;risk prediction;Role;Sampling;Sclerosis;Series;Severities;Severity of illness;Specificity;Standardization;Statistical Data Interpretation;Stroke;Techniques;Tissues;tool;Training;Trichrome stain;United States;whole slide imaging

PROJECT_TITLE: Deep learning approach for the assessment of arterial and arteriolar lesions in kidney biopsies and prediction of cardiovascular risk

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The overall goal of this proposal is to develop novel Adeno associated viral (AAV) for safe and efficient retinal gene delivery. The ability to target foveal photoreceptors is especially significant because this is the area of the retina responsible for acute, daylight vision. A significant portion of our work will be performed in macaques as these hurdles are faithfully recapitulated only in the intact eyes of animals with a fully functioning immune system, and ocular characteristics similar to humans.

PI_NAMEs: BOYE, SHANNON ELIZABETH (contact)

PROJECT_TERMS: Academia;Acute;Address;Adrenal Cortex Hormones;Age related macular degeneration;Anatomy;Animals;Antigen-Presenting Cells;Area;Attention;Basic Science;Benchmarking;Binding;Biodistribution;Biological;Bulla;Bypass;Capsid;Cell Nucleus;Cells;Characteristics;Clinic;Clinical;Clinical Trials;Communities;Data;Dependence;Dependovirus;design;Diabetic Retinopathy;Directed Molecular Evolution;Engineering;Ensure;Eye;fovea centralis;Funding;Gene Delivery;gene therapy;geographic atrophy;Glaucoma;Goals;Heparan Sulfate Proteoglycan;Human;hydrophilicity;Immune;Immune system;immune system function;improved;In Situ;Industry;Inflammation;Inherited;Inner Limiting Membrane;Integration Host Factors;intravitreal injection;Knowledge;Leber's amaurosis;Libraries;Macaca;macula;Mass Spectrum Analysis;Medical;Methods;Modeling;molecular imaging;Muller's cell;Mus;Nature;neurotropic;neutralizing antibody;nonhuman primate;novel;Operative Surgical Procedures;Patients;Peripheral;Phase I/II Clinical Trial;Phase I/II Trial;Photoreceptors;Polysaccharides;Preclinical Drug Development;Primates;rational design;receptor;Resource Sharing;Retina;Retinal Diseases;Retinal Ganglion Cells;Retinal gene therapy;Rodent;Role;Route;RPE65 protein;Safety;Satellite Viruses;screening;Sialic Acids;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;subretinal injection;T cell response;therapy development;Time;Tissues;tool development;trafficking;transduction efficiency;transgene expression;Translating;Translational Research;Treatment Efficacy;Variant;vector;Viral;Virus Receptors;Vision;Visualization;Work;X-Linked Retinoschisis

PROJECT_TITLE: Engineering AAV for safe and efficient gene delivery to the human retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Neurosciences

ORG_CITY: SARASOTA

ORG_NAME: ROSKAMP INSTITUTE, INC.

PHR: Warmer water in the Gulf of Mexico due to climate change, along with nutrient pollution of coastal waterways, have contributed to frequent and repeated Florida red tide (K. brevis) blooms, which impact large segments of gulf coast communities; however, the adverse effects of the neurotoxin, brevetoxin, produced by the algae, on the brain health remain unknown. This proposal will develop clinical tools and blood tests to detect aerosolized brevetoxin exposure- related adverse brain health effects on coastal residents, particularly those with preexisting neurological conditions or genetic predisposition to the harmful effects of environmental toxins. Ultimately, this work will help public health decision-making and developing strategies aimed at protecting the brain health of residents living in coastal communities who frequently endure exposure to harmful algal bloom toxins.

PI_NAMEs: ABDULLAH, LAILA  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: absorption;Adverse effects;aerosolized;Affect;Algae;Alleles;Antibodies;Apolipoprotein E;Atlantic Ocean;Atmosphere;Biological;Biological Markers;Blood;Blood Tests;Brain;brain health;brevetoxin;California;Case Study;Categories;Centers for Disease Control and Prevention (U.S.);Central Nervous System;Cessation of life;Chronic Fatigue Syndrome;climate change;Clinical;coastal water;Communities;Consumption;Decision Making;Detection;Development;Diagnosis;Dose;Drug Kinetics;Ecosystem;Eutrophication;Event;Excretory function;Exhibits;experience;Exposure to;Fatigue;Floods;Florida;Future;Genetic Predisposition to Disease;greenhouse gases;Growth;gulf coast;harmful algal blooms;Headache;Health;high risk;Human;Hurricane;Impaired cognition;Individual;Investigation;Life;Link;Mammals;marine;Marine Toxins;Medical Genetics;Medical History;Memory;Metabolism;Mexico;Migraine;Monitor;Morbidity - disease rate;mortality;Neurologic;Neurologic Effect;Neurologic Examination;Neurologic Symptoms;neurotoxic;Neurotoxins;Nutrient;Oceans;Pacific Ocean;Patients;pharmacokinetic model;Physiological;Physiology;Plasma;Poisoning;Pollution;Public Health;Rain;red tide;Reporting;Research;Resources;respiratory;Respiratory Signs and Symptoms;response;Risk;risk minimization;Shellfish;shellfish contamination;Specimen;stool sample;Symptoms;Temperature;tool;Toxic Environmental Substances;Toxin;United Nations;United States Environmental Protection Agency;Urine;US State;Water;web site;Work

PROJECT_TITLE: Neurological effects of aerosolized red tide neurotoxins

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Neurons undergo massive morphological differentiation as they mature, including the growth of dendrites, axons, and synapses, and membrane transport and regulation of receptor signaling are essential to regulate this expansion in size. Disturbances in membrane traffic have been associated with numerous neurodevelopmental and neurodegenerative disorders. This proposal will determine how neurons regulate membrane traffic in time and space, a fundamental cell biological question with profound implications for neuronal function and disease.

PI_NAMEs: WINCKLER, BETTINA R (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adult;Affect;Axon;Binding;Biological;Biological Assay;Brain-Derived Neurotrophic Factor;Cell Line;Cells;Charcot-Marie-Tooth Disease;Complex;Data;Defect;Degradation Pathway;Dendrites;Development;Disease;Dynein ATPase;Early Endosome;Endosomes;Epidermal Growth Factor Receptor;Equilibrium;experimental study;Fibroblasts;functional outcomes;Goals;Growth;Growth Factor;Growth Factor Receptors;Hippocampus;human disease;Image;late endosome;Length;Ligation;Link;Lysosomes;Mediating;Membrane Protein Traffic;Microfluidics;Molecular;Monitor;Monomeric GTP-Binding Proteins;Morphology;Motility;Motor;mutant;Nervous System;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal cell body;Neurons;novel;Organelles;Pathway interactions;Phenotype;Phosphorylation;Play;Positioning Attribute;postsynaptic;Proteins;proteostasis;receptor;Receptor Signaling;recruit;Regulation;Resolution;Retrieval;Role;sensor;Signal Transduction;Sorting;Stains;stoichiometry;Synapses;synaptic function;TBK1 gene;temporal measurement;Testing;therapeutic target;Time;tool;trafficking;Transmembrane Transport;vesicle transport;Work

PROJECT_TITLE: Organization and Function of Neuronal Endosomes


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Tuft cells function as microbial sensors and direct regional immune responses in many organs. The colon or large intestine harbors the largest and most diverse community of microbes in the body, yet little is known about tuft cell interactions with microbes or the immune system in this part of the gut. This proposal will study how tuft cells in the colon detect specific microbes and how these cells influence inflammation, which may provide new avenues for treating infections or inflammatory disorders.

PI_NAMEs: HOWITT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Agonist;anti-microbial peptide;Bacterial Infections;Cell Communication;Cell Count;Cell Differentiation process;Cell Physiology;Cells;Chemicals;Colon;Cues;cytokine;density;Detection;Disease;Effector Cell;Enteral;enteric infection;enteric pathogen;Epithelial Cells;Epithelial Physiology;Epithelium;Excretory function;Gallbladder;Gastrointestinal tract structure;Genes;Genitourinary system;Germ-Free;Goblet Cells;helminth infection;Helminths;Human;Immune;Immune response;Immune system;Immunity;Immunology;immunoregulation;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;insight;Interleukin-13;intestinal epithelium;Investigation;Knockout Mice;Knowledge;Label;Large Intestine;Literature;Lymphoid Cell;Maps;Measures;Microbe;microbial;microbial community;microbiome;monolayer;mouse model;Mucosal Immunity;Mucous body substance;Mucous Membrane;Mus;novel;Organ;Organoids;Parasites;pathogen;Penetration;Peptides;Population;Production;Protein Secretion;Proteomics;Public Health;receptor;Receptor Cell;Resistance;response;Role;sensor;Sensory;Signal Transduction;Signal Transduction Pathway;Small Intestines;Stimulus;Succinates;Surface;synergism;Taste Perception;Testing;Thick;Tissues;tool;trafficking;Tritrichomonas;TRPM5 gene

PROJECT_TITLE: The role of colonic tuft cells in microbial detection and mucosal immunity

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: We have identified multiple early differentiation paths that B cells can take following their initial immune activation, with one leading directly to the generation of antibody secreting cells, and the other to cells bearing a memory signature. To be able to design future immunotherapies and vaccines to infectious diseases, an understanding of the early transcriptional and epigenetic processes that govern this cell fate decision is needed. The aims of this study will define the epigenetic architecture of early naïve and memory B cell differentiation, identify genes and mechanisms that direct immunity, and ascribe the roles of key epigenetic modulators to this important immunological defense system.

PI_NAMEs: BOSS, JEREMY M. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Address;Adopted;Affect;Anatomy;Antibodies;Antibody Formation;Antigens;Architecture;Autoimmune Diseases;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;base;biological adaptation to stress;Biological Assay;CD4 Positive T Lymphocytes;Cell division;Cell Fate Control;Cells;Chickens;Chromatin;Communicable Diseases;conditional knockout;congenic;Coupled;Data;design;differential expression;Disease;Disparate;Distal;DNA;Enabling Factors;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Event;EZH2 gene;Ficoll;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Transcription;Globulins;Heritability;Heterogeneity;Humoral Immunities;immune activation;Immune response;Immunity;Immunoglobulin-Secreting Cells;Immunologics;Immunotherapeutic agent;Immunotherapy;in vivo;in vivo evaluation;Individual;influenzavirus;KDM1A gene;Kinetics;Lipopolysaccharides;Literature;Location;Mediating;Memory;Memory B-Lymphocyte;Metabolism;Modeling;Molecular;mouse model;Mus;Parasitic infection;Pathogenicity;Pathway interactions;Phase;Plasma Cells;Play;precursor cell;Process;programs;Proliferating;promoter;Regulatory Element;Reporter;response;Role;Series;Shapes;single-cell RNA sequencing;Source;Structure;Structure of germinal center of lymph node;System;T-Lymphocyte;Testing;transcription factor;Transcription Process;transcriptome;transcriptomics;Transgenic Organisms;Vaccines;Virus Diseases

PROJECT_TITLE: Epigenetic regulation of early B cell differentiation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Functional impairment and loss of neurons are characteristics of neurodegenerative diseases. Numerous genes associated with these devastating diseases act in organelle quality control pathways. Our work focuses on investigating the mechanisms of neuronal selective recycling pathways involving the lysosome machinery using quantitative cell biological and proteomics approaches.

PI_NAMEs: ORDUREAU, ALBAN  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;age related neurodegeneration;age-related disease;Aging;Astrocytes;Autophagocytosis;Autophagosome;Behavioral;Binding;Biochemical;Biological;biological adaptation to stress;blood glucose regulation;Brain;Calcium;Cancer cell line;carbohydrate metabolism;Carbohydrates;cell type;Cells;Cellular Structures;Characteristics;Cues;Cytoprotection;Cytosol;cytotoxic;Data;Development;differentiation in vitro;Digestion;Disease;Endoplasmic Reticulum;Exhibits;experimental study;Functional impairment;functional loss;Genes;Glucose;Glycogen;hazard;Health;Homeostasis;Human;Impairment;in vitro Model;Induced Neurons;induced pluripotent stem cell;innovation;Knockout Mice;Link;lipid metabolism;Lysosomes;macromolecule;Maintenance;Maps;Membrane;Metabolic stress;misfolded protein;Modeling;Molecular;Molecular Structure;mouse model;Mus;Muscle Fibers;Mutation;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroimmune;Neurologic;neuron loss;Neuronal Differentiation;Neurons;novel;novel therapeutics;Nutrient;Organelles;Pathologic;Pathway interactions;Pharmacologic Substance;Phenotype;Physiological;Play;Population;postmitotic;prepulse inhibition;Prevalence;Process;protein aggregation;protein degradation;Proteins;Proteome;Proteomics;proteostasis;Quality Control;receptor;receptor binding;Recycling;Regulation;Reporting;Research;response;Role;Series;Signal Pathway;Signal Transduction;Specificity;Starch;Starvation;Stress;Tissues;United States;Vesicle;Work

PROJECT_TITLE: Mechanistic basis for endoplasmic reticulum-driven cytoprotection by selective autophagy in neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The proposed research is relevant to public health because developing novel treatment approaches for cardiac fibrosis and heart failure represents an urgent unmet societal need in the United States. Thus, the proposed research is highly relevant to the NHLBI’s mission to support medical research on heart failure, which affects ~6 million people in the Unites States and is a leading cause of mortality, hospitalization, and healthcare expenditures in our country. This proposed research is relevant to NIH’s mission to seek fundamental knowledge that will help to enhance health and reduce the burden of human illness and disability.

PI_NAMEs: MCKINSEY, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Adult;Affect;Atomic Force Microscopy;autocrine;biobank;Carbon;Cardiac;cardiac magnetic resonance imaging;Cells;Chromatin Modeling;Chronic;Cicatrix;comorbidity;coronary fibrosis;Country;Data;Deoxycorticosterone;Deposition;design;Development;disability;Echocardiography;EFRAC;Eicosanoid Degradation;Eicosanoids;Enzymes;epigenetic memory;epigenome;epigenomics;Event;Extracellular Matrix;Extracellular Matrix Proteins;Fatty Acids;Female;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Hand;Health;Health Expenditures;Heart;Heart Block;Heart Diseases;Heart failure;Heart Research;Histologic;Hospitalization;Human;Hypertension;in vivo;inhibitor;Knowledge;Left;lipidomics;Lipids;Machine Learning;male;MAPK3 gene;Mass Spectrum Analysis;Measures;Mediating;Medical Research;Metabolic Diseases;Mission;Modeling;Molecular;Morphology;mortality;Mus;Myocardial;Myofibroblast;National Heart, Lung, and Blood Institute;novel;Organ;Oxidoreductase;Paint;paracrine;Pathogenesis;Pathologic;Persons;Phenotype;phosphoproteomics;preservation;pressure;prevent;Production;Public Health;Regulation;Research;research clinical testing;response;Reverse Transcription;Role;Side;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Sodium Chloride;Stress;targeted treatment;Technology;Testing;Tissues;transcriptional reprogramming;Translations;United States;United States National Institutes of Health

PROJECT_TITLE: 15-PGDH-Mediated Eicosanoid Degradation in Cardiac Fibrosis and Heart Failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: PROJECT NARRATIVE Global cerebral ischemia arises as a consequence of cardiac arrest and affects ~200,000 Americans each year, however, an effective treatment for neurodegeneration and cognitive deficits associated with global ischemia remains an unmet medical need. The proposed research will examine a role for TREM1-triggered neuroinflammation in global ischemia pathology and test novel inhibitors of TREM1 and BRD4 that may be useful to ameliorate the neurological deficits of global cerebral ischemia. It is anticipated that these translational studies will create a foundation for developing novel therapeutic strategies to ameliorate this serious medical condition.

PI_NAMEs: HWANG, JEE-YEON  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;American;Astrocytes;Attenuated;Behavioral Assay;Blood flow;Brain;Brain Diseases;Cells;Cerebral Ischemia;Cessation of life;chromatin remodeling;Clinical Trials;Cognition;Cognitive deficits;cognitive function;confocal imaging;Data;Disease;effective therapy;Electrophysiology (science);Emergency treatment;EP300 gene;Epigenetic Process;epigenetic regulation;Flow Cytometry;Foundations;Functional disorder;Gene Expression Alteration;Genetic Transcription;Heart Arrest;heart function;hippocampal pyramidal neuron;Hippocampus;histone modification;Immune;immune cell infiltrate;Immunohistochemistry;improved outcome;in vivo;Induced Neurons;Inflammatory;inhibitor;Innate Immune Response;innovation;Ischemia;ITGAM gene;Knockout Mice;Malignant Neoplasms;Massive Parallel Sequencing;Mediating;Mediator;Medical;Membrane;microchip;Microglia;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;neuroinflammation;Neurologic Deficit;neuron loss;Neurons;next generation;novel;novel therapeutic intervention;novel therapeutics;Oxygen;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Peptides;pharmacologic;preservation;Proteins;Rattus;receptor;Reporter;Reporting;Research;response;Role;Signal Transduction;small molecule;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;transcriptome sequencing;translational study

PROJECT_TITLE: A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: GOLDEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO SCHOOL OF MINES

PHR: Project Narrative In the pancreatic islets of Langerhans, the peri-islet ECM provides a critical barrier to immune infiltration that is lost in early type 1 diabetes (T1D) and may contribute to islet dysfunction and death prior to clinical diagnosis of disease. Poor knowledge regarding the molecular mechanisms contributing to loss of the peri-islet ECM in early stages of T1D is a major barrier limiting the development of therapies to preserve β-cell mass and function in patients at risk for developing T1D. The goal of this study is to determine if cytokine-stressed β-cells contribute to loss of the peri-islet ECM in early T1D and determine how loss the peri-islet ECM impacts β-cell survival and function in preclinical T1D.

PI_NAMEs: FARNSWORTH, NIKKI L. (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: 3-Dimensional;ADAMTS;Age;Autoantibodies;autoreactivity;Beta Cell;Biological Assay;Biomimetics;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;clinical diagnosis;confocal imaging;cytokine;Data;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;disease diagnosis;Encapsulated;endoplasmic reticulum stress;Enzymes;experimental study;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Functional disorder;Gelatinase A;Glucose;Glycolysis;Goals;Human;Immune;immune cell infiltrate;improved;Infiltration;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;islet;Islets of Langerhans;Knowledge;Laminin;laminin-10;Link;Matrix Metalloproteinases;Measures;Mediating;Mediator;Metabolic;Mitochondria;Molecular;Morphology;Mus;new therapeutic target;NOD/SCID mouse;novel;Pancreas;Patients;pre-clinical;Prediabetes syndrome;Predisposition;preservation;programs;protein activation;protein kinase C-delta;Risk;Role;scaffold;sensor;Stains;Stress;therapy development;Tracer;Western Blotting

PROJECT_TITLE: The Role of the Pancreas Microenvironment in Regulating Islet Function and Survival in Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-D (02)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Project Narrative Infection with the food-borne liver fluke, Opisthorchis viverrini, a parasitic worm, which is prevalent in East Asia, frequently leads to cholangiocarcinoma (bile duct cancer). While the prognosis for this liver cancer is dismal, especially in the resource-poor regions when the liver fluke parasite is endemic, we have discovered proteins that are essential to the parasite. Here we focus on developing an anti-infection/anti-cancer vaccine targeting these essential-to-the-parasite proteins.

PI_NAMEs: BRINDLEY, PAUL J (contact);LAHA, THEWARACH ;LOUKAS, ALEXANDER CONSTANTINE

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Adjuvant;Age;anti-cancer;Antigen Targeting;Antigens;Area;Asian;Award;bile duct;Bile Duct Carcinoma;Biliary;biliary tract;biobank;Biochemical;Biological;Cancer Model;cancer therapy;Cancer Vaccines;carcinogenesis;carcinogenicity;Carcinogens;Caspase;Cell Communication;Cell Proliferation;Cervical cancer vaccine;Cessation of life;Cholangiocarcinoma;cholangiocyte;chronic wound;Clinic;Coculture Techniques;cohort;combat;Combined Vaccines;Communication;Complement;Country;CRISPR/Cas technology;Data;Development;Digestion;egg;Elements;Encapsulated;Enzyme-Linked Immunosorbent Assay;Epithelium;Equation;extracellular;extracellular vesicles;Far East;Fasciola hepatica;feeding;Fibrosis;fitness;foodborne;functional genomics;Funding;Goals;granulin;Growth Factor;Hamsters;Helminths;Hepatocarcinogenesis;Homeostasis;Human;human model;Human Papillomavirus;IgE;Immune response;immunogenic;In Vitro;in vivo;Incidence;Infection;innovation;Interruption;knockout gene;Laos;Link;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Messenger RNA;Modeling;Molecular;Mucous body substance;National Institute of Allergy and Infectious Disease;novel;Nutrient;nutrition;Nutritional;Opisthorchis viverrini;Organoids;Parasites;parasitism;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Persons;Phenotype;Population;Poverty;Preparation;Process;Prognosis;Proliferating;Property;Protein Subunits;Proteins;Public Health;Recombinant Proteins;repaired;Reporting;Resource-limited setting;response;Risk;Risk Factors;RNA vaccine;Rodent Model;Role;Safety;Sampling;secretory protein;Serum;Standardization;Subunit Vaccines;Testing;Thailand;Therapeutic;thrombospondin 2;translational potential;Trematoda;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;vaccine efficacy;vaccine-induced antibodies;Vaccines;Virulence Factors;wound healing;Wound Repair Pathway

PROJECT_TITLE: Anti-cancer vaccine targeting the host-parasite interface during fluke infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Nearly 1.25 million Americans aged 65 years and older receive hospice services annually, with hospice medications paid for by both the Medicare Part D prescription drug benefit and the Medicare Part A Hospice Benefit. In 2014, the Centers for Medicare & Medicaid Services (CMS) shifted policy to increasingly place the burden of medication payment on hospice agencies’ operating budgets and away from Part D. The impact of this policy change on patient and hospice outcomes is largely unclear, and we propose to address this gap with a nationwide retrospective interrupted time series analysis using secondary data from CMS.

PI_NAMEs: ALCUSKY, MATTHEW ;TJIA, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Impact of New Hospice Drug Policies on Expenditures, Utilization, Prescribing Quality, and Access

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Many of the tools used in gene therapy and biomedical research (e.g. CRISPR-Cas systems) were discovered by studying bacteria and their viruses. This work will identify new regulators for CRISPR-Cas systems and compare different strategies to reduce their undesired off-target effects. This work will also find new bacterial- viral interactions that may influence biomedical and research technologies in years to come.

PI_NAMEs: MARINO, NICOLE D. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Address;Affinity Chromatography;Bacteria;Bacterial Proteins;Bacteriophages;BCAR1 gene;Binding;Biological Assay;Biomedical Research;Candidate Disease Gene;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;cytotoxicity;DNA Binding Domain;endonuclease;Evolution;Future;gene discovery;gene editing technology;Gene Fusion;gene therapy;gene-editing approach;Genes;Genetic Engineering;genome editing;Goals;Human;Immune;immune activation;Immune system;immune system function;immunogenicity;Immunologic Stimulation;Immunologic Tests;improved;Individual;Infection;inhibitor;insight;Lentivirus Vector;Libraries;Mass Spectrum Analysis;Measures;Mentors;Methods;Molecular Biology;Nature;next generation sequencing;novel;off-target mutation;Operon;Orthologous Gene;Outcome;post-doctoral training;programs;protein protein interaction;Proteins;reconstitution;Regulator Genes;Reporter Genes;Research;restriction enzyme;Safety;side effect;System;Technology;Testing;Therapeutic Studies;tool;transcription factor;vector;Viral;Viral Vector;Virus;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: Discovery of novel phage-bacterial interactions

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BALTIMORE

PHR: Project Narrative There is growing evidence that distinct subgroups of scleroderma patients have an increased risk of cancer, and that unique scleroderma immune responses, alone or in combination, associate with cancer protection. It remains unknown whether cancer drives the autoimmune response more broadly in scleroderma, whether diversified immune responses exert potent anti-tumor pressure, and whether cancer treatment is effective scleroderma therapy. To address these knowledge gaps, this proposal will (i) study the value of innovative cancer and immune response measurements in identifying patients with incident cancer diagnosis, and (ii) investigate the relationships between malignancy, the immune response, and scleroderma disease activity in two of the largest scleroderma cohorts in the US.

PI_NAMEs: CASCIOLA-ROSEN, LIVIA A;SHAH, AMI AALOK (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Age Factors;Aneuploidy;Antibodies;Autoantibodies;Autoantigens;Autoimmune Responses;autoimmune rheumatologic disease;Autoimmunity;Biological;biomarker identification;Cancer Detection;cancer diagnosis;Cancer Remission;cancer risk;cancer therapy;Centromere;Clinical;clinical development;clinical diagnosis;clinically actionable;clinically relevant;cohort;Data;Development;Disease;DNA Sequence Alteration;Epitopes;evidence base;Evolution;F Factor;Foundations;Frequencies;Genes;Genetic;high risk;Immune response;Immune System Diseases;Immunosuppression;improved;innovation;insight;Knowledge;Link;liquid biopsy;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Methods;Modality;Mutate;Mutation;novel;Onset of illness;Outcome;patient oriented;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Plasma;polygenic risk score;Polymerase;pressure;Process;prospective;Prospective Studies;Proteins;Recording of previous events;recruit;response;Rheumatism;Risk Factors;risk stratification;RNA Polymerase III;Scleroderma;Screening for cancer;Severities;Shapes;Somatic Mutation;Specificity;Statistical Models;Subgroup;Symptoms;Testing;Time;tool;tumor;tumor DNA;Tumor Immunity;Tumor Markers;validation studies

PROJECT_TITLE: Autoantibodies define scleroderma subgroups with distinct relationships to cancer

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

PHR: Project Narrative Blood trauma, arterial remodeling, and dysfunctional vasoregulation during non-pulsatile artificial circulation contribute to patient adverse events. The BiVACOR, a first-of-its-kind, impeller-based total artificial heart with the ability to generate continuous (non-pulsatile) or pulsatile outflow, will be used to investigate in vivo effects of non-pulsatile versus pulsatile flow. Findings will inform development of artificial pulsatility algorithms that mimic physiologic pulsatility in order to reduce adverse events in patients.

PI_NAMEs: BARTOLI, CARLO R (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Activities of Daily Living;Adverse event;Algorithms;Apoptosis;Architecture;arterial remodeling;Baroreflex;Blood;Blood flow;blood pump;Brain hemorrhage;Cattle;Chronic;Circulation;Clinical;Collagen;Data;Development;Devices;Diastolic Hypertension;Elastin;Emerging Technologies;Endothelium;Event;Exercise;Extracellular Matrix;Financial cost;Frequencies;Functional disorder;gastrointestinal;Generations;Glycocalyx;Goals;Heart failure;hemocompatibility;hemodynamics;Hemolysis;Hemorrhage;Hypertension;improved;In Vitro;in vivo;Inflammation;insight;Investigation;left ventricular assist device;Life;Maintenance;Metabolism;Modeling;Morbidity - disease rate;mortality;Muscle;Nerve;Orthostatic Hypotension;Oxidative Stress;Pathologic;Patients;Periodicity;Physiological;Physiology;Platelet Activation;Postural adjustments;pressure;prevent;Pulsatile Flow;Pulse Pressure;Quality of life;Refractory;Sleep;Speed;Stroke;Suction;Thrombosis;Tissues;total artificial heart;Trauma;Tunica Media;Vascular remodeling;Vasomotor;von Willebrand Factor

PROJECT_TITLE: Blood Trauma, Vascular Remodeling, and Vasoregulation with Total Body Continuous Versus Pulsatile Artificial Circulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]