NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: Narragansett

ORG_NAME: PRO-CHANGE BEHAVIOR SYSTEMS, INC.

ORG_STATE: RI

PHR: 8. Project Narrative In an increasingly polarized world, workplaces serve as critical sources of belonging for their employees; however, members of the LGBTQ+ community continue to experience thwarted belonging as many organizations lack the policies and procedures necessary to make LGBTQ+ workers feel safe, connected, and included, especially given the transformation of the workplace, as precipitated by the COVID-19 pandemic that has led to an increase in burnout and, often, a reduction in the possibilities for work-based social connections. The proposed research will employ a participatory design approach to create and examine the acceptability and preliminary effects of Bridges, an advanced Learning Management System and messaging program that will leverage insights from behavior change science to address thwarted belongingness among LGBTQ+ workers. By utilizing the science of behavior change and accessible technology to address limitations of current employee programs to increase feelings of belonging, this easily disseminable, potentially cost-effective, and highly tailored solution would overcome the limitations of existing company-sponsored wellness programs and interventions for workplace belonging that target LGBTQ+ workers.

PI_NAMEs: EVERS, KERRY  (contact)

PROJECT_TERMS: Address;behavior change;bullying;burnout;Caring;Communication;Communities;community violence;coping;cost effective;COVID-19 pandemic;design;Development;digital;digital intervention;Discrimination;diversity and inclusion;Effectiveness;Emotional;Employee;experience;Face;Feeling;flexibility;Gender Identity;harassment;Health;Health behavior change;health disparity;Hostility;Human;Hybrids;improved;indexing;Individual;innovation;insight;Interpersonal Relations;Interpersonal Violence;Intervention;Laws;Learning;Lesbian Gay Bisexual Transgender Queer;Loneliness;long term COVID-19 pandemic impacts;Longevity;Maps;marginalization;member;Mental Health;Motivation;Names;Occupations;Organizational Culture;Outcome;Participant;Personal Satisfaction;Persons;Phase;physical conditioning;Pilot Projects;pilot test;Policies;prevent;Procedures;Process;Productivity;Program Acceptability;programs;prototype;Public Health;Readiness;Recommendation;recruit;Research;resilience;Risk;Schedule;Science;Sex Orientation;sexual identity;social;Social isolation;social stigma;Social support;Source;Specific qualifier value;Stress;success;Supervision;System;Technology;Testing;Text Messaging;theories;tool;Translating;trend;usability;Wellness Program;Work;Workplace

PROJECT_TITLE: Bridges: A digital intervention to increase workplace belonging


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is more aggressive in youth than in adults and management can be improved through precise, data-driven approaches. Metformin is the only oral treatment option approved for T2D in youth but current dosing strategies are ineffective at maintaining durability of glycemic control. The goals of this project are to evaluate the pharmacological, clinical and physiological determinants of metformin response in youth with T2D and to develop and evaluate a clinically usable precision dosing algorithm in order to ultimately improve clinical outcomes for youth with T2D.

PI_NAMEs: SRINIVASAN, SHYLAJA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;Algorithms;arm;Biostatistical Methods;Body Size;career;career development;Child;Childhood;Childhood diabetes;Clinic;Clinical;clinical decision-making;Clinical Pharmacology;Clinical Trials;conventional dosing;cost effective treatment;Data;Data Collection;Development;Disease Progression;Dose;drug disposition;Drug Kinetics;emerging adult;experience;FDA approved;follow-up;Foundations;Funding;Future;Genetic;Genetic Research;glycemic control;Goals;hands on research;Heritability;improved;insight;interpatient variability;Intervention;K-Series Research Career Programs;Kidney;large datasets;Measures;Medical;Mentors;Metformin;Methodology;Methods;Modeling;mortality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;Oral;Outcome;patient oriented;pediatric patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Physiological;Pilot Projects;Population;Preparation;Prevalence;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Research;Research Personnel;response;Risk;Sampling;skills;success;Testing;Therapeutic;tool;Training;Treatment Failure;treatment response;usability;young adult;Youth

PROJECT_TITLE: A comprehensive approach to understanding the determinants of metformin pharmacokinetics and pharmacodynamics in youth with type 2 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: OVERALL The Minnesota HHEAR Targeted Analysis Laboratory brings together highly talented scientists from the University of Minnesota and the Minnesota Department of Health to provide a national resource for exploring environmental, lifestyle, and related factors that can affect human health. Scientists from around the United States studying health issues will use this resource to provide critical information about the role of environmental exposures in human disease. The outcome will lead to more effective disease prevention strategies.

PI_NAMEs: PETERSON, LISA A (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Affect;Age;Analytical Chemistry;Area;Beverages;Biological;Biological Assay;Biological Markers;Blood;Carcinogens;Client;Clinical Research;Consultations;Creativeness;Data;Data Analyses;data centers;design;Development;dietary;disorder prevention;DNA Adducts;DNA analysis;Dose;Eating;Environmental Exposure;Environmental Impact;epidemiology study;experience;Exposure to;Formalin;Goals;Hair;Health;Human;human disease;Infrastructure;International;Laboratories;Laboratory Scientists;Life Style;Link;Mass Spectrum Analysis;Measurement;Measures;Methods;Minnesota;Nutritional;Outcome;outreach;Plasma;Prevention strategy;Procedures;Productivity;programs;Quality Control;Research Design;Research Personnel;Resources;Role;Saliva;Sampling;Scientist;Stress;Structure of nail of toe;Talents;Testing;tissue fixing;tobacco exposure;toxicant;United States;Universities;Urine;Variant


PROJECT_TERMS: Benchmarking;Communication;Consultations;Data;data centers;Data Set;Development;Ensure;Future;Goals;Laboratories;laboratory experiment;Maintenance;material transfer agreement;meetings;member;Minnesota;National Institute of Environmental Health Sciences;operation;outreach;Preparation;Procedures;programs;Progress Reports;Quality Control;Regulation;Reporting;Research Design;Research Personnel;Resources;response;sample collection;Sampling;standardize measure;success;United States National Institutes of Health;Update;Work;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ORONO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: OVERALL NARRATIVE  The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation of Cellular Behavior in Response to Extracellular Cues.

PI_NAMEs: HENRY, CLARISSA A (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;aging related disease;APLN gene;Autophagocytosis;Biological;Biomedical Engineering;Biomedical Research;career;cell behavior;cell growth regulation;Cell Reprogramming;Cell Signaling Process;cell type;Cells;Centers of Research Excellence;Communicable Diseases;Core Facility;Cues;Cultured Cells;Development;Disease;Doctor's Degree;Engineering;Environment;experience;extracellular;Facility Designs;Faculty;Funding;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;graduate school;graduate student;Grant;Homeostasis;Image;Image Analysis;imaging facilities;Industry;infectious disease treatment;Influenza;innate immune function;Institution;Investments;Island;Laboratories;Leadership;Lytic;Maine;Medical center;meetings;Mentors;Mentorship;Microscopy;migration;Modeling;Motility;Muscle;muscle aging;Muscle Cells;muscle regeneration;Myopathy;Natural regeneration;Neuromuscular Diseases;New England;Positioning Attribute;programs;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;response;Running;Science;Senior Scientist;Signal Transduction;Students;success;teaching laboratory;The Jackson Laboratory;Training;United States National Institutes of Health;Universities;Virus;Virus Diseases;virus infection mechanism;Yeasts;Zebrafish


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: ADMINISTRATIVE AND MENTORING CORE NARRATIVE The Administrative and Mentoring Core will provide administrative leadership and direction for COBRE activities across the two partner biomedical research institutions: the University of Maine (UMaine) and Mount Desert Island Biological Laboratory (MDIBL). This core will ensure that the research project leaders achieve independent RO1-level funding as well as transform the overall biomedical research environment at the University of Maine.

PROJECT_TERMS: Advisory Committees;Aging;Biological;Biological Sciences;Biomedical Research;Budgets;career development;cell behavior;cell growth regulation;Centers of Research Excellence;Collaborations;collaborative environment;Consultations;Cues;Data;design;Development Plans;Ensure;Environment;Evaluation;experience;extracellular;Faculty;Fostering;Funding;Future;graduate school;Health Personnel;hospital care;Human Resources;Individual;Infrastructure;Institute of Medicine (U.S.);Institution;Intention;Island;Laboratories;Leadership;Maine;Medical center;Medicine;meetings;Mentors;Microscopy;Modeling;Pilot Projects;Preparation;Process;Productivity;professor;Program Evaluation;programs;Progress Reports;Publications;recruit;Regenerative Medicine;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Science;Scientist;Series;Strategic Planning;Structure;symposium;The Jackson Laboratory;Time Management;United States National Institutes of Health;Universities;Zebrafish

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PHR: Narrative The establishment of the Microscopy and Image Analysis Core COBRE facility will fulfill important current and future needs for COBRE investigators. It will provide wraparound services for use of high-end microscopy tools, image analysis software and data management architecture, serving the five COBRE projects.

PI_NAMEs: WHEELER, ROBERT T. (contact)

PROJECT_TERMS: Address;Affect;Aging;Architecture;Biochemistry;Biological;biological systems;Biology;Biomedical Engineering;Biomedical Research;cell behavior;cell growth regulation;cell motility;Cells;Cellular Structures;Centers of Research Excellence;Chemical Engineering;Communicable Diseases;Communities;Computer software;Core Facility;Cues;Data;data management;Data Storage and Retrieval;design;early-career faculty;empowerment;Engineering;environmental change;Equipment;experience;Experimental Designs;experimental study;extracellular;Fluorescence;Funding;Future;Goals;Grant;Head;Image;Image Analysis;Immune;Immune response;improved;in vivo;Infection;Infrastructure;innovation;Institution;Instruction;Island;Label;Light;longitudinal design;Maine;Mentorship;Microscope;Microscopy;migration;Modeling;Molecular;Morphogenesis;Muscle;muscle repair;novel;open source;Optics;Outcome;Output;Partner in relationship;Physics;programs;Proteins;Publications;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Resources;response;Sampling;Science;Scientist;Services;Signal Transduction;Specialist;Stimulus;Structure;System;theories;Time;Tissues;tool;Training;Translating;Translation Process;two-photon;ultra high resolution;United States National Institutes of Health;Universities;Viral;Visualization;Work;Zebrafish

PROJECT_TITLE: Microscopy and Image Analysis Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Neurodegenerative;Neurosciences

PI_NAMEs: MAGINNIS, MELISSA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;antiviral drug development;Astrocytes;Biological Assay;Biological Models;Biology;Brain;brain cell;cell behavior;Cell Communication;Cell Culture Techniques;cell growth regulation;cell immortalization;Cell model;Cell Reprogramming;cell transformation;cell type;Cells;Central Nervous System;Chronic;chronic infection;Clathrin;combinatorial;Comparative Genomic Analysis;Coronavirus;Cues;Data;Demyelinating Diseases;design;Development;Disease;Disease Outcome;effective therapy;Endocytosis;experimental study;extracellular;G Protein-Coupled Receptor Signaling;gain of function;Gene Expression;Genetic Transcription;Goals;Growth;high throughput analysis;high-throughput drug screening;HIV;Human;Immune;Immunocompromised Host;immunomodulatory therapies;Immunosuppression;improved;in vitro Model;in vivo;Individual;Infection;innovation;insight;Invaded;JC Virus;Kidney;kidney cell;kidney infection;Knowledge;Left;loss of function;Lytic;Lytic Phase;Malignant Neoplasms;Marketing;Mediating;Mitogen-Activated Protein Kinases;Modeling;Multiple Sclerosis;Neuroglia;novel;Oligodendroglia;Outcome;Pathogenesis;pathogenic virus;Pathology;Pathway interactions;Pharmaceutical Preparations;Polyomavirus Infections;Population;Predisposition;Prevalence;prevent;Primary Cell Cultures;Production;programs;Progressive Disease;Progressive Multifocal Leukoencephalopathy;protein expression;Publishing;receptor;Regulation;Research;Research Project Grants;response;Risk;Role;Serotonin;serotonin receptor;Signal Induction;Signal Pathway;Signal Transduction;Testing;Therapeutic;Tissues;transcriptome sequencing;transcriptomic profiling;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Receptors;Virus Replication;Work

PROJECT_TITLE: Cellular Programming in Persistent Versus Lytic Viral Infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

PI_NAMEs: KING, BENJAMIN L (contact)

PROJECT_TERMS: Acetylcysteine;Acute;Adhesions;Antioxidants;biological adaptation to stress;Biopsy;Biosensor;cell behavior;cell growth regulation;cell motility;Chemotaxis;confocal imaging;Creatine Kinase;Cues;Defect;design;Disease;Embryo;Exhibits;Extensive Necrosis;extracellular;Extracellular Matrix;Fiber;Focal Infection;gene regulatory network;Genetic;Glutathione;Goals;Grant;Hospitalization;Hour;Hydrogen Peroxide;Immune system;in vivo;in vivo imaging;Individual;Infection;Inflammatory Response;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza epidemic;influenza infection;influenza virus vaccine;influenzavirus;innate immune function;Innate Immune System;insight;Integration Host Factors;Invaded;Knowledge;Laboratories;Ligands;Link;Macrophage;Mediating;MicroRNAs;migration;Modeling;Muscle;Muscle Cells;muscle degeneration;mutant;Myelogenous;Myocarditis;Myopathy;Natural Immunity;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;overexpression;Oxidative Stress;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Peroxidases;Population;Production;recruit;Regulation;Reporter;Reporting;Respiratory Signs and Symptoms;response;Role;Sagittaria;Sarcolemma;Serum;Severities;Signal Pathway;Signal Transduction;Site;Skeletal Muscle;strength training;Symptoms;System;Testing;therapy development;Tissues;tool;transcriptome sequencing;Transgenes;Viral;Virus;Virus Diseases;Visualization;Zebrafish

PROJECT_TITLE: Innate Immune Function in Influenza-Associated Myopathy


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Estrogen;Genetics;Regenerative Medicine

PI_NAMEs: TALBOT, JARED COFFIN (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Agonist;Antibodies;Binding;Biological Models;Body Regions;cell behavior;cell growth regulation;cell motility;cell type;Cells;cellular imaging;Chemicals;chemokine;Chest;cofactor;Cues;CXC Chemokines;CXCR4 Receptors;Data;Destinations;Development;Embryo;epithelial to mesenchymal transition;Estrogen Receptor 2;experimental study;extracellular;FDA approved;Future;Gene Expression;Genes;Genetic;genetic approach;Genetic Epistasis;Growth;homeodomain;Human;human disease;Impairment;improved;in vivo;inhibitor;insight;Knock-out;Label;Libraries;Ligands;Limb structure;Location;Malignant Neoplasms;Mesenchymal;MET gene;Metastasis Induction;migration;Migration Assay;molecular drug target;Morphogenesis;Motility;Movement;Muscle;muscle regeneration;mutant;Myoblasts;Myomatous neoplasm;Natural regeneration;Neoplasm Metastasis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phosphorylation;Physiologic pulse;Process;progenitor;promoter;Protein Dephosphorylation;Proteins;receptor;response;screening;Shapes;Signal Transduction;Skeletal muscle structure of neck;small molecule libraries;Somites;Source;Specific qualifier value;Stream;Stromal Cell-Derived Factor 1;System;Testing;Therapeutic;tissue regeneration;tool;transcription factor;Transgenic Organisms;tumor;tumor progression;vertebrate embryos;Zebrafish

PROJECT_TITLE: Motility and Guidance Signals Control Migration of Muscle Precursors


PI_NAMEs: KELLEY, JOSHUA BRIAN (contact)

PROJECT_TERMS: Attenuated;Autophagocytosis;Binding;cell behavior;cell growth regulation;Cell Physiology;Cells;Cellular biology;combat;combinatorial;Cues;desensitization;detector;Development;Disease;Drug Receptors;Drug Targeting;Endocytosis;epsin;extracellular;Feedback;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic regulatory protein;GTP-Binding Protein Regulators;GTP-Binding Proteins;Health;Human;Human Biology;human disease;Hyperactivity;immune function;Mediating;member;Molecular;Morphogenesis;mutant;Mutation;novel;novel strategies;Organelles;Output;Partner in relationship;Pathway interactions;Pharmaceutical Preparations;Pheromone;Phosphorylation;Physiological;PIK3CG gene;Process;Proteins;receptor;Receptor Activation;receptor internalization;Receptor Signaling;Recording of previous events;Recycling;Regulation;Research;response;Role;Signal Induction;Signal Pathway;Signal Transduction;sorting nexins;spatiotemporal;Stress;stressor;System;Testing;Tissues;tumor progression;Ubiquitin family;Vacuolar Protein Sorting;Vacuole;Visualization;yeast genetics;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanisms of GPCR-induced Autophagy


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MADELAINE, ROMAIN  (contact)

PROJECT_TERMS: Acute;Affect;age effect;age related;age related decline;Age Years;age-related muscle loss;Aging;Agonist;angiogenesis;animal old age;anti aging;Anti-Inflammatory Agents;APLN gene;Atrophic;Autoimmune Diseases;Autophagocytosis;Biogenesis;Biological;Biological Assay;Biological Models;cell behavior;cell growth regulation;Cell Therapy;cell type;Cells;Centers of Research Excellence;Chemicals;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;Data;Diabetes Mellitus;Disease;Endothelial Cells;Etiology;experimental study;extracellular;Fishes;Future;gain of function;Gene Expression Profile;Genes;Genetic;genetic approach;genome editing;Goals;Health;healthy aging;Homeostasis;Image;Immune;improved;Infection;Inflammation;Inflammatory;injured;Injury;insight;intercellular communication;juvenile animal;Knock-out;life span;Long-Term Effects;Longitudinal Studies;loss of function;Macrophage;Malignant Neoplasms;Metabolic Diseases;Mitochondria;Molecular;mortality risk;Muscle;muscle aging;muscle degeneration;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;muscle strength;Muscular Atrophy;mutant;Myopathy;Natural regeneration;novel;Obesity;old mice;Peptide Signal Sequences;Peptides;Persons;pharmacologic;Phenotype;pleiotropism;Population;prevent;Proliferating;receptor;Receptor Activation;Receptor Gene;Recovery;regenerative;Regenerative response;Rejuvenation;response;Role;sarcopenia;senescence;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;skeletal muscle wasting;stem cell function;stem cell homeostasis;Swimming;Symptoms;System;Technology;Testing;Therapeutic;therapeutic target;tissue degeneration;Tissues;transcriptomics;Transgenic Organisms;Zebrafish

PROJECT_TITLE: Apelin Signaling in Muscle Regeneration


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative  Our research program is devoted to cell-specific drug delivery platforms for the treatment of diverse diseases. We will integrate our specialty in pharmaceutics, pharmaceutical chemistry, biomedical engineering, materials formulation, and animal studies to design and validate new drug delivery systems. The goal is to translate our scientific results and technological inventions into more effective drug delivery systems.

PI_NAMEs: DONG, YIZHOU  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3' Untranslated Regions;Address;Animal Model;Animals;Area;base editing;Benzene;Biomedical Engineering;cell type;Cells;Data;design;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Factor VIII;Formulation;Foundations;Gene Expression;Germ Cells;Glycolipids;Goals;Hemophilia A;Hepatocyte;Human;in vivo;innovation;invention;Lead;lipid nanoparticle;Lipids;Macrophage;medical specialties;Messenger RNA;mouse model;mRNA delivery;Multiple Bacterial Drug Resistance;Mus;nanoparticle;novel;novel therapeutics;Pharmaceutical Chemistry;Pharmacy (field);Physiological;Production;programs;Proteins;Research;Safety;stem cell delivery;stem cells;System;Technology;Testing;Therapeutic;tool;Translating;Untranslated Regions;Vitamins

PROJECT_TITLE: Construction of in vivo mRNA delivery systems

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: TOWSON

ORG_NAME: PZA INNOVATION LLC

ORG_STATE: MD

PHR: Narratives:  This project aims to develop a reliable and accurate pyrazinamide susceptibility testing that can be used routinely in tuberculosis laboratories worldwide. The testing is designed to be reliable, inexpensive, simple, and safe to use, providing rapid and accurate results of pyrazinamide susceptibility. The implementation of this testing will guide healthcare providers in giving the most effective treatment to TB patients and help curb TB drug resistance. The impact of this innovation on public health will be significant.

PI_NAMEs: SHI, WANLIANG  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adopted;Agar;Agreement;Area;Automobile Driving;Award;Bacteria;Bangladesh;Basic Science;Businesses;Cessation of life;Clinic;Clinical;clinical decision support;clinical decision-making;clinically relevant;Collaborations;commercialization;Communicable Diseases;cost;cost effective;cost effectiveness;Data;design;Developed Countries;Development;diagnostic algorithm;Disease;Drug Combinations;Drug Monitoring;Drug resistance;drug resistance development;Drug resistance in tuberculosis;drug standard;effective therapy;Ensure;Equipment;experience;FDA approved;field study;Fluorescence;Foundations;genome sequencing;Geographic Locations;Goals;Growth;Health Personnel;improved;in-vitro diagnostics;Infection;innovation;Instruction;instrument;Italy;Laboratories;Liquid substance;low and middle-income countries;low income country;Manuals;Medicine;meetings;Methods;miniaturize;Modification;Molecular;Multidrug-Resistant Tuberculosis;mycobacterial;Mycobacterium tuberculosis;Oxygen;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Phenotype;Predisposition;Prevalence;prevent;Process;Protocols documentation;prototype;Public Health;Pyrazinamide;Pyrazinamide resistance;Recommendation;Regimen;Reproducibility;Research Personnel;Resistance;risk mitigation;Science;Sensitivity and Specificity;sensor;Small Business Innovation Research Grant;Solid;South Africa;Specific qualifier value;Standardization;success;System;Test Result;Testing;Time;tool;Training;Treatment Cost;treatment duration;Treatment outcome;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;whole genome;Work;Writing

PROJECT_TITLE: Development of a Rapid Phenotypic Pyrazinamide Susceptibility Testing for Mycobacterium tuberculosis Using Well-Standardized Protocol

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (13)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Sexual assault is highly prevalent among college students and is associated with high risk for alcohol misuse and co-occurring posttraumatic stress in survivors of all genders, but substantial barriers exist to college students’ ability to access effective in-person preventative interventions for these conditions. The current study proposes to optimize the first app-based preventative intervention with demonstrated efficacy in reducing alcohol misuse, called THRIVE, by testing the unique and synergistic effects of its components in a factorial randomized controlled trial. If we are successful in identifying a highly effective and efficient version of THRIVE, this intervention would represent a highly-scalable strategy to reduce the substantial burden of posttraumatic stress and alcohol misuse on students and campus service systems.

PI_NAMEs: DWORKIN, EMILY RAPHAEL (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Alcohol consumption;alcohol misuse;Attention;Award;Behavioral;Caring;Cognitive;college;coping;critical period;design;drinking;Early Intervention;effective intervention;efficacy trial;Elements;Enrollment;Ensure;ethnic minority;Evaluation;experience;Feedback;Female;Frequencies;Future;Gender;high risk;Institution;Intervention;Intoxication;member;men;mHealth;mhealth interventions;Mobile Health Application;Monitor;multiphase optimization strategy;Participant;Patient Self-Report;Persons;Phase;pilot test;pilot trial;post intervention;post-trauma;post-traumatic stress;Post-Traumatic Stress Disorders;Preparation;prevent;preventive intervention;prototype;racial minority;Randomized;randomized trial;Randomized, Controlled Trials;reduced alcohol use;Risk;Schedule;Services;sexual assault;Students;Survivors;System;telephone coaching;Testing;Time;Trauma;trauma exposure;Universities;university student;usability;Work

PROJECT_TITLE: Project THRIVE: Testing an app-based early intervention to reduce alcohol use and PTSD after sexual assault

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Neurosciences;Obesity;Osteoarthritis;Pain Research

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative Osteoarthritis (OA) is a leading cause of disability with an economic burden of >$60 billion per year, with ~60M million people in the US suffering from chronic OA pain – a figure that is increasing due to increasing life expectancy and increasing obesity. Current drug treatments for pain are associated with side effects: ~17,000 individuals die each year from NSAID-associated side effects, and opioid use leads to misuse, abuse and overdose, contributing to the ~50,000 individuals dying each year from opioid overdose. Safer, more effective and less addictive pain relief strategies are desperately needed, and our proposed research investigating a hitherto unrecognized pathway driving OA pain will identify novel therapeutic targets that will ultimately lead to new, safe strategies for alleviating OA pain.

PI_NAMEs: LASCELLES, DUNCAN ;MISHRA, SANTOSH K. (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Activities of Daily Living;addiction;Address;Adult;Affect;afferent nerve;Afferent Neurons;American;Animal Model;Arthralgia;Arthritis;Automobile Driving;Behavioral;Behavioral Assay;Binding;Biological Products;Body Weight decreased;Canis familiaris;central pain;Chronic;chronic pain;clinically relevant;Complex;Data;Degenerative polyarthritis;Development;disability;Discipline;Disease;Distant;Economic Burden;Enzyme-Linked Immunosorbent Assay;Evaluation;Exercise;Family;Felis catus;gastrointestinal;Generations;glial cell-line derived neurotrophic factor;Hemorrhage;Human;Hypersensitivity;Imaging Techniques;In Vitro;Incidence;Individual;inhibitor;Injections;Injury;irritation;joint destruction;Joints;Knockout Mice;Life Expectancy;Link;Medial meniscus structure;Mediating;Modeling;Molecular;Monoclonal Antibodies;motor impairment;mouse model;Mus;Myocardial Infarction;Nerve;Neural Pathways;neuromechanism;Neuronal Plasticity;Neurons;neurotrophic factor;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;Nonpharmacologic Therapy;novel;Obesity;Operative Surgical Procedures;Opioid;opioid overdose;opioid use;osteoarthritis pain;Outcome Measure;Overdose;Pain;Pain management;Pain Measurement;pain relief;pain sensitivity;Pathway interactions;Patients;Persistent pain;Persons;Pharmacotherapy;Proteins;Proto-Oncogenes;Quantitative Reverse Transcriptase PCR;receptor;Receptor Protein-Tyrosine Kinases;Research;response to injury;Risk;Role;side effect;Signal Induction;Signal Transduction;Societies;Solid;Source;Steroids;Stroke;Synovial Membrane;Testing;Therapeutic;therapeutic target;therapeutically effective;tissue degeneration;Tissues;Transgenic Mice;TRP channel;Up-Regulation;Weight maintenance regimen;Work

PROJECT_TITLE: Evaluation of mechanistic role of artemin/GFRα3 signaling in osteoarthritis pain

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Taylor, Martin | K08 (PA-20-203) | PROJECT NARRATIVE Selective therapeutic modulation of the two mTOR effector complexes, mTORC1 and mTORC2, is a key goal for the treatment of diabetes and many types of cancers because dysregulation of these signaling complexes play central and often opposing roles in disease pathophysiology, but we lack the detailed structural and mechanistic information about both complexes that would enable development of these therapies. For example, in type 2 diabetes, overfeeding results in hyperstimulation of mTORC1, which measures nutrients, resulting in inhibition of mTORC2, which then fails to transmit the critical insulin signal and leads to insulin resistance; in this context, it would be advantageous to selectively inhibit mTORC1, preventing this feedback loop, or selectively activate mTORC2, mitigating insulin resistance. The overarching goal of the scientific arm of this project is to learn about the structure and mechanism of mTORC2 in detail so that we could develop these selective strategies for better treatment of diabetes and cancer.

PI_NAMEs: TAYLOR, MARTIN S (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Affect;Affinity;Aging;Allosteric Regulation;Apoptosis;arm;Autophagocytosis;Award;Binding;Biochemical;Bioinformatics;Biological Assay;Biology;Biomedical Research;blood glucose regulation;cancer type;career;career development;Catabolic Process;Catalysis;cell growth;cell motility;chemical conjugate;Chemicals;Clinical;Collaborations;Color;Complex;crosslink;Cryoelectron Microscopy;Cytoskeleton;Data;Data Analyses;density;design;Development;Development Plans;Diabetes Mellitus;Disease;Ensure;Eukaryotic Cell;experience;Feedback;feeding;follow-up;Fostering;FRAP1 gene;Functional disorder;gastrointestinal;General Hospitals;Generations;glucose transport;Glucose Transporter;Goals;Growth;Growth Factor;Homeostasis;Hospital Departments;Human;human disease;Hypertension;Impairment;inhibitor;insight;Institution;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;interest;International;Ion Channel;Kinetics;Knowledge;Learning;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Massachusetts;Measures;Mentors;Metabolic;Metabolic syndrome;Molecular Conformation;Monomeric GTP-Binding Proteins;mTOR inhibition;nanobodies;Neoplasm Metastasis;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Oncogenic;Pathologist;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physicians;PIK3CG gene;Play;Positioning Attribute;prevent;Principal Investigator;programs;Proliferating;protein complex;Protein Engineering;Proteins;Proteomics;Reaction;Reagent;receptor sensitivity;Regulation;Research;research and development;Research Personnel;Resolution;rho;rho GTP-Binding Proteins;Role;Science;Scientist;Series;Signal Transduction;skill acquisition;small molecule;Solid Neoplasm;structural biology;Structure;Substrate Interaction;success;System;Techniques;Testing;Therapeutic;therapy development;Time;tool;Training;transmission process;Treatment Failure;Tuberous Sclerosis;Universities;Up-Regulation;Visualization

PROJECT_TITLE: Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The goal of this project is to develop and validate a novel machine learning technology for noninvasive detection, identification and imaging of the epileptogenic brain in focal epilepsy patients. The successful development of the proposed technology promises to significantly improve the clinical management of drug-resistant epilepsy, which is currently limited, benefiting numerous patients and the healthcare system.

PI_NAMEs: HE, BIN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Algorithms;Biological Markers;Brain;brain tissue;Clinic;Clinical;Clinical Data;Clinical Management;Computer software;Data;density;Detection;Development;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Evaluation;Event;Excision;Frequencies;Functional Magnetic Resonance Imaging;Goals;Healthcare Systems;High Frequency Oscillation;Image;imaging approach;imaging modality;Imaging technology;Implant;improved;Intervention;Intractable Epilepsy;learning strategy;Location;Machine Learning;machine learning framework;Maps;Monte Carlo Method;Morphology;Nature;Nervous System Disorder;neuroimaging;new technology;Non-Invasive Detection;novel;novel marker;novel strategies;open source;Operative Surgical Procedures;Outcome;Partial Epilepsies;Pathologic;Pathology;Patients;Pharmacologic Substance;Phase;Procedures;Process;programs;Research;Research Project Grants;Resolution;Scalp structure;Seizures;signal processing;simulation;Source;Spatial Distribution;Techniques;Technology;temporal measurement;Testing;unsupervised learning;Validation;Visual

PROJECT_TITLE: Electrophysiological Source Imaging of Partial Epilepsy


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: CAPES OVERALL: PROJECT NARRATIVE  The potential public health impact of The Center for Accelerating Practices to End Suicide through Technology Translation ( is profound, because the knowledge generated will be relevant to many diverse settings and populations at risk for suicide. CAPES will identify the best evidence-based suicide care technologies and study them systematically to identify key strategies for maximizing their translation to clinical care so they can be put in the hands of clinicians, patients, and families instead of sitting on the “virtual shelf.” This improved ability to identify and monitor suicide risk and provide high-quality care for individuals identified as at-risk will reduce suicide attempts and suicide, which also prevents the suffering experienced by families, friends, and communities that results from losing someone to suicide. CAPES )

PI_NAMEs: BOUDREAUX, EDWIN D (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Acceleration;Accident and Emergency department;acute care;Administrator;Adoption;Algorithms;American;Anemia;Award;Biometry;Businesses;Caring;Cause of Death;Cellular Phone;Clinical;clinical care;clinical practice;Clinical Trials Design;Collaborations;college;Communities;community partners;Computer software;computerized;dashboard;Data;Data Analyses;data management;Data Science;Depression screen;design;Development;digital health;Dimensions;Discipline;dissemination strategy;economic evaluation;Economics;efficacy evaluation;Electronic Health Record;Elements;Engineering;Enrollment;Ensure;Environment;Epidemiology;Ethics;evidence base;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Faculty;Family;Feeling suicidal;Fostering;Friends;Funding;Future;graduate student;Growth;Health;health care settings;health disparity;health economics;Health system;Healthcare Systems;Hybrids;implementation framework;implementation science;implementation/effectiveness;improved;Individual;Information Technology;Infrastructure;innovation;insight;Internist;Intervention;intervention delivery;Knowledge;Learning;Lived experience;Machine Learning;Mental Health;Methods;mobile application;Modeling;Monitor;National Institute of Mental Health;operation;Outcome;Outpatients;patient population;Patients;Peer Review;Performance;person centered;Pilot Projects;Policies;Population Heterogeneity;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;practice setting;prevent;Prevention;Primary Care;Process;Psychologist;Public Health;Public Health Informatics;Publications;Quality of Care;Recording of previous events;reducing suicide;Research;Research Activity;Research Design;Research Personnel;research to practice;Resources;Risk;risk prediction;routine care;Science;screening;Services;socioeconomics;Structure;suicidal;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Symptoms;synergism;System;Technology;technology development;Technology Transfer;Testing;Training;Translating;translational goal;translational progress;Translational Research;Translations;United States;United States National Institutes of Health;university student;virtual;Voice

PROJECT_TITLE: The Center for Accelerating Practices to End Suicide through Technology Translation (CAPES)


PHR: CAPES ADMINISTRATIVE (ADMIN) CORE: PROJECT NARRATIVE See Project Narrative in the Overall component.

PROJECT_TERMS: Acceleration;Adoption;Affect;Award;Bibliometrics;Businesses;career development;Caring;Clinical;clinical translation;Collaborations;commercialization;Communication;Communities;community engagement;cost;design;Development;Development Plans;digital health;Discipline;Ecosystem;Education;Educational Curriculum;Educational workshop;Environment;Ethics;Evaluation;experience;Faculty;faculty support;Family;Fostering;Funding;Future;Goals;graduate student;Health Technology;Healthcare Systems;improved;Individual;Infrastructure;innovation;Innovation Corps;Knowledge;Leadership;Legal;Life Cycle Stages;medical schools;Methods;Mission;Monitor;operation;Patients;Peer Review;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Privacy;Process;programs;Public Health;Research;Research Peer Review;Research Personnel;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Seasons;skills;social;social media;stakeholder perspectives;success;suicidal risk;Suicide;Suicide prevention;synergism;Technology;technology development;Technology Transfer;Training;training opportunity;Translations;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Vision;web site;Work


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Deaths attributed to stimulant misuse are also increasing at an alarming public health rate. This application proposes research to evaluate the effectiveness of muscarinic acetylcholine agonists to treat stimulant misuse.

PI_NAMEs: BANKS, MATTHEW L (contact);ELTIT, JOSE MIGUEL

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acceleration;Admission activity;Agonist;Animals;antagonist;Attenuated;Basic Science;Behavior;Behavioral;Biological Assay;Biosensor;Cessation of life;Cholinergic Agonists;CHRM1 gene;Clinical;Clinical Data;Clinical Trials;Cocaine;Cocaine Abuse;Cocaine use disorder;Data;Decision Making;Development;Dopamine;Dose;Drug Addiction;Drug Use Disorder;Effectiveness;effectiveness evaluation;Experimental Designs;experimental study;Failure;Female;Food;Funding;Human;human subject;in vivo;Laboratory Animals;Laboratory Study;male;Measures;Mediator;Methamphetamine;methamphetamine abuse;Methamphetamine use disorder;Microdialysis;Modeling;Monitor;Muscarinic Acetylcholine Receptor;Muscarinics;National Institute of Drug Abuse;Negative Reinforcements;Neurobiology;Neurotransmitters;non-drug;Nucleus Accumbens;overdose death;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;pre-clinical;Prefrontal Cortex;Procedures;Public Health;Publications;Rattus;reinforcer;Research;Research Subjects;Self Administration;Series;Serotonin Agonists;Signal Transduction;social;Source;Stimulant;stimulant abuse;stimulant misuse;stimulant use disorder;System;Testing;therapeutic candidate;Time;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Pharmacology of Stimulant Choice

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We propose to identify and modulate key structural elements of biosynthetic enzymes that activate and transfer fatty acids for their incorporation into bioactive natural products. The directed evolution of the olefin synthase model system will allow us to dissect how these enzymes select and process specific fatty acid substrates for transfer to polyketide synthase domains. We will also develop a heterologous host for the expression of these fatty acid-activating biosynthetic pathways and the production of targeted bioactive natural products to facilitate metabolic engineering and bioengineering.

PI_NAMEs: YNIGEZ-GUTIERREZ, AUDREY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acids;Alkenes;Anabolism;analog;Architecture;Area;Binding Proteins;Binding Sites;bioactive natural products;Bioinformatics;Biological Models;Biomedical Engineering;Carrier Proteins;Chimera organism;Chimeric Proteins;Complex;Development;Directed Molecular Evolution;Docking;Elements;Engineering;Enzymes;experimental study;Fatty Acids;Future;Gatekeeping;Gene Cluster;Gene Expression;Generations;Goals;Health;Homologous Gene;Human;Hybrids;improved;in vivo;Individual;Knowledge;Length;Libraries;Ligase;Link;liquid chromatography mass spectrometry;Logic;Mass Fragmentography;Mass Spectrum Analysis;Metabolic;metabolic engineering;Metabolic Pathway;Metabolism;metabolomics;Methods;Modeling;natural product derivative;Natural Products;novel;Nuclear Magnetic Resonance;Pathway interactions;peptide synthase;pharmacologic;polyketide synthase;prevent;Process;Production;Property;protein protein interaction;Proteins;Pseudomonas putida;Research Proposals;Ribosomes;scaffold;screening;secondary metabolite;Structure;Structure-Activity Relationship;System;Temperature;Tertiary Protein Structure;Therapeutic;Translations;Type I Polyketide Synthase;Work;yeast two hybrid system

PROJECT_TITLE: Directed evolution towards bioengineering of fatty acid-activating natural product pathways


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies. NIBCh enables large-scale analyses of multi-modal brain MRI data by mapping such data into a compact coordinate system of informative neuroimaging signatures implemented by our library of ML models. The over-arching primary goal of our program is to provide the software tools that will allow users to contribute to an actively growing community-based dimensional neuroimaging system that will utilize machine learning models to provide rich, yet precise, compact, concise, and informative representations of brain structure, function and connectivity.

PI_NAMEs: DAVATZIKOS, CHRISTOS  (contact);FAN, YONG ;NASRALLAH, ILYA M;SHOU, HAOCHANG

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Adopted;Adult;Aging;aging brain;analysis pipeline;Artificial Intelligence;Atlases;Back;Brain;brain magnetic resonance imaging;Clinical;cloud based;cluster computing;combat;Communities;Complex;Computer software;Data;Data Analyses;data sharing;deep learning;deep learning model;Detection;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Ecosystem;Educational workshop;Functional Magnetic Resonance Imaging;Genomics;Goals;Heterogeneity;High Performance Computing;Image;Individual;Infrastructure;Internet;Knowledge Discovery;Libraries;Machine Learning;machine learning method;machine learning model;Maps;meetings;Methods;Modeling;multimodality;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;neuropsychiatric disorder;novel;Online Systems;Pattern;Persons;Phenotype;Process;programs;Pythons;Research;Research Personnel;Software Tools;Source;Standardization;structural determinants;Structure;System;Testing;tool;Training;Variant;Visual;Visualization;web interface;web portal;Work

PROJECT_TITLE: The Neuroimaging Brain Chart Software Suite


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Cell fate transitions depend upon the establishment of specific transcriptional programs, of which chromatin reorganization is a key regulatory layer. The germinal center (GC) B-cell maturation program is an ideal model to study the dynamics of chromatin architecture because 1) the mechanisms driving the rapid and massive phenotypic shifts are unknown and 2) GC B-cells manifest many hallmarks of cancer cells, meaning these unknown mechanisms maintain their importance in B-cell lymphomas. This proposed research will integrate whole-genome sequencing and chromatin conformation capture maps (pcHiC, Pore-C) to significantly advance our understanding of how 3D chromatin chromunities, interactive networks of enhancers, are rewired to establish cell identity in the humoral immune response and how large-scale chromosomal rearrangements in B-cell lymphomas may drive the formation of aberrant chromunities to promote aberrant phenotypes and drive lymphomagenesis.

PI_NAMEs: DURMAZ, CEYDA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;Architecture;Automobile Driving;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Binding Sites;Biological;Biological Assay;cancer cell;cancer genomics;Cell Maturation;cell type;Cells;Chromatin;Chromatin Conformation Capture and Sequencing;Chromosomal Rearrangement;chromosome conformation capture;Clonal Expansion;Complex;computer framework;Data;Disease;DNA;DNA Sequence Rearrangement;Enhancers;Epigenetic Process;Gene Activation;Gene Dosage;Gene Expression;gene interaction;gene network;Gene Structure;Genes;Genetic Transcription;Genome;genome sequencing;Genomic Instability;genomic locus;Genomics;high risk;Humoral Immunities;Immune response;Immunoglobulin Somatic Hypermutation;insight;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant lymphoid neoplasm;malignant phenotype;Maps;meter;Modeling;Molecular Conformation;Mutation;Nature;novel;Oncogenes;Oncogenic;Organism;patient derived xenograft model;Patients;Pattern;Phenotype;Physiological;Probability;Process;programs;Proliferating;promoter;Reaction;Regulatory Element;Research;Rest;Role;Site;Somatic Mutation;spatiotemporal;Structure;Structure of germinal center of lymph node;transcription factor;Transcriptional Activation;transcriptional reprogramming;transcriptome sequencing;tumor;Tumor Suppressor Proteins;tumorigenesis;Variant;whole genome;Work

PROJECT_TITLE: Chromunities Drive Transcriptional Reprogramming in Humoral Immunity and B-cell Lymphomas


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infectious Diseases;Prevention;Sepsis;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Sepsis is a major global health problem, associated with 20% of all global deaths each year, and in the United States sepsis is most common among older adults, people with multimorbidity, and those in communities with lower healthcare access and quality. The objective of this project is to improve understanding of the factors influencing individual sepsis risk, and the relationships between these risk factors, by using community- informed multilevel and agent-based models. By establishing critical new insights into sepsis prevention, the proposed work will greatly impact public health policy, sepsis prevention efforts, and care for older adults with chronic conditions in the United States.

PI_NAMEs: RUDD, KRISTINA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;acute infection;Adult;Age;Aging;aging morbidity;Award;Biological;career;Caring;Censuses;Cessation of life;Chronic;Communities;community engaged research;Community Services;community-level factor;Complex;Cost Control;County;Data;Data Sources;Diabetes Mellitus;Disease;driving force;Electronic Health Record;Epidemiologic Methods;epidemiological model;Epidemiology;Family;Functional disorder;Geography;global health;Goals;Health;health care availability;Health Care Costs;health disparity;Health Policy;Health Professional;Health Services;Health system;high risk;Hospitalization;Immune response;improved;Incidence;Individual;Infection;insight;Knowledge;Life;Link;Location;Malignant Neoplasms;Mentors;model building;Modeling;mortality;multilevel analysis;multiple chronic conditions;older adult;Organ;Patients;Pattern;Pennsylvania;Persons;Play;Population;Poverty;Prevention;profiles in patients;Public Health;Recording of previous events;Research;Research Personnel;Research Training;response;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Sepsis;septic patients;social;Social Conditions;Social Environment;Subgroup;Substance abuse problem;syndemic;Syndrome;Techniques;Testing;theories;Time;United States;Universities;Vaccination;Violence;Work

PROJECT_TITLE: The Syndemic of Sepsis, Multimorbidity, Aging, and Low Healthcare Access and Quality in the United States

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Bioengineering;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Suicide;Suicide Prevention

PHR: CAPES METHODS CORE: PROJECT NARRATIVE See Project Narrative in the Overall component.

PI_NAMEs: KIEFE, CATARINA I. (contact)

PROJECT_TERMS: Acceleration;Adoption;advanced analytics;Applications Grants;Articulation;Artificial Intelligence;Award;Biometry;Caring;Cellular Phone;clinical care;clinical practice;Clinical Research;Clinical Trials;Collaborations;Common Data Element;computer scientist;computerized;Data;data acquisition;Data Science;design;Dimensions;Discipline;Early Diagnosis;economic evaluation;Effectiveness;effectiveness/implementation hybrid;efficacy study;Engineering;Ensure;Epidemiology;Evaluation;Extramural Activities;Faculty;Family;Fostering;Funding;Goals;health economics;Health Services Research;Health system;Healthcare;implementation design;implementation framework;implementation research;implementation science;implementation study;improved;Incubators;Individual;Industrialization;innovation;Knowledge;Leadership;Learning;Logic;Machine Learning;machine learning algorithm;Measurement;member;Methodology;Methods;Modeling;Monitor;novel;operation;Patients;person centered;Physicians;Pilot Projects;Predictive Analytics;Production;Psychometrics;Public Health;Quasi-experiment;Randomized, Controlled Trials;Reporting;Research;Research Activity;Research Design;Research Project Grants;Resources;Rest;Science;Scientist;Societies;Specialist;statistical and machine learning;Statistical Computing;suicidal risk;Suicide;Suicide prevention;synergism;technological innovation;Technology;technology development;Telephone;Testing;Training Activity;translational approach;Translational Research;Translations;Vendor;Vision;Voice;Work

PROJECT_TITLE: Methods Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: The proposed studies in this research project are relevant to public health because the translational mammalian models such as those developed in this proposal are crucial for evaluating the efficacy of oncolytic virotherapy for cancer. This is particularly important for GBM, a disease for which few therapeutic strategies exist. These models will provide a much-needed platform for determining appropriate patient populations and evaluating effective single and combination immunotherapy treatment strategies.

PI_NAMEs: LANG, FREDERICK F (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Ablation;Address;Adenovirus Infections;Adenoviruses;Adrenal Cortex Hormones;Adult;Animal Model;Animals;anti-tumor immune response;Antibodies;Automobile Driving;Brain Neoplasms;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Line;checkpoint inhibition;Clinical;clinical implementation;Clustered Regularly Interspaced Short Palindromic Repeats;Combination immunotherapy;combinatorial;Data;Development;Disease;Effector Cell;efficacy evaluation;Engineering;Evaluation;experience;Exposure to;Gene Targeting;Genetic;Glioblastoma;Glioma;Hamsters;Human;Immune;immune activation;Immune checkpoint inhibitor;immune function;Immune response;Immune system;Immunocompetent;Immunologic Memory;immunomodulatory therapies;immunoregulation;Immunotherapy;Impairment;improved;in vivo;Infection;innovation;Intracranial Neoplasms;Laboratories;Malignant Neoplasms;Mediating;Mesenchymal;Mesocricetus auratus;Modeling;Molecular;molecular subtypes;mouse model;Mus;neoplastic cell;nerve stem cell;novel;novel therapeutics;Oncogenes;oncolysis;Oncolytic;oncolytic adenovirus;oncolytic virotherapy;Oncolytic viruses;Outcome;patient population;Patients;permissiveness;pharmacologic;Phase I Clinical Trials;Positioning Attribute;pre-clinical;preclinical study;Preclinical Testing;Predisposition;Production;Public Health;Publishing;Recurrence;Reproducibility;Research;Research Personnel;Research Project Grants;response;Solid Neoplasm;stem cells;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Time;translational approach;translational model;Translational Research;Treatment Efficacy;treatment strategy;tumor;Tumor Stem Cells;Tumor Suppressor Proteins;Viral;Virus;Virus Replication;Xenograft procedure

PROJECT_TITLE: A Novel Adenoviral-Permissive, Immunocompetent Hamster Model to Evaluate Oncolytic Adenoviral Therapy for Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOUISVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Electronic cigarettes (e-cigs) aerosolize a mixture of chemical solvents, flavor additives and nicotine, and inhalation of the resultant aerosol by e-cigarette users has unknown effects on the heart. In this project, we will examine how specific flavoring chemicals that are inhaled during e-cigarette use impact the function of mouse and human heart cells and tissues. Ultimately, this study will advance knowledge of the toxicity of e-cigarettes, which will direct new regulation of e-liquid constituents based on their potential for adverse effects on the heart.

PI_NAMEs: CARLL, ALEX PERROW (contact);NYSTORIAK, MATTHEW A

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Action Potentials;Acute;Adult;Adverse effects;aerosolized;Aerosols;Affect;air filter;Aldehydes;Arrhythmia;Biological;Biological Assay;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;Cardiovascular Physiology;Cardiovascular system;Cessation of life;Chemicals;Chronic;Circulation;clinical predictors;Conscious;Consumption;Data;Dependence;Devices;Dose;e-cigarette aerosols;Electrocardiogram;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Electrophysiology (science);Emerging Tobacco Products;Equilibrium;Evaluation;experimental study;Exposure to;Flavoring;Food Additives;Functional disorder;Future;Heart;heart cell;heart function;Heart Rate;Heating;high risk;Human;In Vitro;in vivo;Incidence;Individual;Ingestion;Inhalation;Knowledge;Link;Long-Term Effects;Lung;Malignant Neoplasms;manufacture;Marketing;Modeling;Monitor;Mus;Negative Finding;Nicotine;nicotine exposure;Oral Ingestion;Outcome;Pathologic;Pathway interactions;Performance;Periodicity;Policies;Prevalence;Propylene Glycols;Regulation;Research Priority;respiratory;response;Risk;Safety;Serum;Smoker;Smoking;Solvents;stem;Structure;sudden cardiac death;Sum;Testing;Tissues;tobacco products;tobacco regulatory science;Toxic effect;Toxicology;Toxin;vegetable glycerin;Ventricular;Ventricular Arrhythmia;Work;Youth

PROJECT_TITLE: Systematic identification of cardiotoxic e-cigarette flavorants


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Our program will continue to address the need for recruiting, motivating, and preparing undergraduate diversity students toward careers in biomedical research and medicine by providing an engaging summer research and medicine training program. The significance of our program will be that it is a mechanism that will increase the number of diversity individuals who will pursue biomedical research and health professions related careers.

PI_NAMEs: REPINE, JOHN E (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Athletic;Atmosphere;Biomedical Research;Blood;career;Career Choice;Clinical;clinical conference;clinical training;college;Colorado;Communities;Dental Schools;design;Dimensions;Disease;Education;education evaluation;education research;Educational Assessment;Educational process of instructing;Elements;Enrollment;Evaluation;experience;Exposure to;Faculty;Friends;Funding;Future;Goals;graduate school;graduate student;Growth;hands on research;Health;Health Occupations;Healthcare;Heart;Hour;Immunologics;improved;Individual;Inflammation;Inflammatory;innovation;Instruction;interest;Laboratories;laboratory experience;Laboratory Research;Leadership;Learning;Lung;Medical;Medical center;medical schools;Medical Students;Medicine;Mentors;Mentorship;multidisciplinary;National Heart, Lung, and Blood Institute;Nursing Schools;Oxidative Stress;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;Physicians;posters;Preparation;Process;programs;Published Comment;Radiology Specialty;recruit;Recruitment Activity;Research;Research Personnel;Research Training;role model;Schools;Scientist;social;Students;success;summer program;summer research;summer student;teacher mentor;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;Veterans;Visible Human Project;Vocational Guidance

PROJECT_TITLE: Colorado Summer Research Training for Undergraduate Diversity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

PHR: JASPR (SIGNATURE PROJECT): NARRATIVE See Project Narrative in the Overall component.

PROJECT_TERMS: Acceleration;Accident and Emergency department;active comparator;acute care;Address;Adopted;Adoption;Adult;Affect;Age;Ambulatory Care;arm;Award;Behavioral;behavioral health;Behavioral inhibition;Black race;care delivery;Caring;Cessation of life;Clinical;clinical care;Colorado;comparative effectiveness study;completed suicide;Consumption;coping;cost;Counseling;Data;design;digital;digital technology;Distress;economic outcome;Effectiveness;efficacy study;efficacy testing;Electronic Health Record;Elements;Emergency Care;Emergency Department patient;Emergency department visit;Environment;Ethnic Origin;evidence base;Evidence based intervention;Evidence based practice;Exercise;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Feeling suicidal;Foundations;Funding;Future;Grant;Health;health care economics;Health Care Surveys;Healthcare Systems;high risk;high risk population;Home;Hospitalization;Hybrids;implementation design;implementation framework;implementation outcomes;implementation process;implementation science;implementation strategy;improved;In Situ;indexing;Individual;innovation;inpatient psychiatric treatment;Interruption;Intervention;Interview;Investigation;Investigational Therapies;Knowledge;Learning Module;Libraries;Life;Lived experience;Mediating;Mediation;medical schools;Methodology;Methods;Modeling;Monitor;National Institute of Mental Health;Nature;novel;Ohio;Outcome;Output;patient engagement;Patient Outcomes Assessments;Patients;Performance;Persons;point of care;prevent;Process;Productivity;Race;Randomized;Randomized, Controlled Trials;Registries;Research Design;Research Domain Criteria;Research Personnel;Research Project Grants;Resources;Risk Assessment;routine care;Safety;Sampling;scale up;secondary outcome;Self-Injurious Behavior;Series;sex;single-blind trial;Site;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;smartphone application;Social support;Solid;Standardization;Subgroup;success;suicidal;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;Surveys;System;Technology;technology development;Telephone;Time;Translating;Translations;treatment as usual;trial comparing;usability;Visit;Vital Statistics;Wait Time;wasting

PROJECT_TITLE: Signature Research Project


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Services;Pediatric;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Project Narrative Tobacco and electronic nicotine delivery system (ENDS) use are associated with numerous serious negative health outcomes among youth. Despite evidence to support hospital-based interventions among adult tobacco users, to date no such interventions have been developed or tested for use in the pediatric hospital, where many at-risk youth receive care. This study will design and iteratively refine a novel tobacco and ENDS use intervention for adolescents and young adults and evaluate preliminary efficacy and implementation outcomes of this intervention in the pediatric hospital setting with the overall goal to decrease ENDS use and improve health outcomes in this at-risk population.

PI_NAMEs: MASONBRINK, ABBEY  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;Academy;Acute;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Alcohol consumption;Alcohols;American;Asthma;Behavior Therapy;Biochemical;care coordination;Caring;Cigarette;cigarette smoking;Clinical;combustible cigarette;comorbidity;Complex;computerized;Consolidated Framework for Implementation Research;contextual factors;Counseling;critical developmental period;Data;Decision Support Systems;design;Development;Devices;Diabetes Mellitus;disability;Disease;Disease Outbreaks;Effectiveness;efficacy evaluation;efficacy outcomes;Electronic cigarette;Electronic Nicotine Delivery Systems;Electronics;Evaluation;evidence base;Feedback;follow-up;Future;Goals;Guidelines;Health;Health Educators;Healthcare Systems;High School Student;hospital care;Hospitalization;Hospitalized Adolescent;Hospitals;Hybrids;implementation barriers;implementation evaluation;implementation facilitators;implementation framework;implementation intervention;implementation measures;implementation outcomes;implementation trial;improved;Intervention;intervention refinement;Intervention Trial;Link;Medical;Mental disorders;Middle School Student;motivational enhancement therapy;Nicotine Withdrawal;novel;Outcome;Parents;Patient Self-Report;Patients;Pediatric Hospitals;Pediatrics;Pharmacotherapy;Pilot Projects;pilot test;pilot trial;poor health outcome;Populations at Risk;Prevalence;preventable death;Primary Care;primary care setting;primary care visit;primary outcome;Process;Provider;Randomized;randomized trial;Recommendation;Reporting;Research;Research Activity;respiratory;Risk;screening;secondary outcome;skills;Substance Use Disorder;substance use treatment;support tools;Techniques;Testing;therapy design;Tobacco;tobacco control;tobacco products;Tobacco use;tobacco user;United States;United States Preventative Services Task Force;vape pens;vaping;vaping associated lung injury;Visit;Work;Youth

PROJECT_TITLE: Development and Implementation of a Tobacco and ENDS Use Intervention for Adolescents and Young Adults in the Pediatric Hospital


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Rare Diseases

PHR: Project Narrative Genetic variants encoding for sarcomeric proteins are major contributors to the pathogenesis of genetic cardiomypathies such as dilated cardiomyopathy and hypertrophic cardiomyopathy. Current approach to study these variants lack ability to screen many variants at once. Here we propose to use simulations, experimental measurements and data analytics to classify variants and predict response to therapies.

PI_NAMEs: MOUSSAVI-HARAMI, FARID  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;analytical method;Animal Model;Animals;Area;Biochemical;Biological Assay;Biophysical Process;Biophysics;Calibration;Cardiac;Cardiac Myocytes;Cardiomyopathies;Categories;Cell model;Classification;classification algorithm;Complex;Computer Models;computer studies;Data;Data Analytics;Data Set;Development;Dilated Cardiomyopathy;dimension reduction;Disease;experimental study;Filament;Functional disorder;Generations;Genetic;genetic testing;genetic variant;Goals;Graph;Grouping;Health Professional;heart function;high throughput screening;Human;human induced pluripotent stem cells;human tissue;Hypertrophic Cardiomyopathy;In Vitro;in vivo;indexing;individual patient;individualized medicine;inherited cardiomyopathy;Investigation;Knowledge;large datasets;Location;machine learning algorithm;machine learning method;machine learning model;Measurement;Mechanics;Methods;Microfilaments;Modeling;Molecular;molecular phenotype;Muscle;Muscle Cells;new therapeutic target;novel;overexpression;palliative;Pathogenesis;Patients;Phenotype;precision medicine;Precision therapeutics;Prediction of Response to Therapy;Property;Proteins;Research Personnel;Rodent;Rodent Model;Sarcomeres;simulation;small molecule;success;System;targeted treatment;Testing;therapeutic target;Thick Filament;Thin Filament;Time;Tissue Model;Training;treatment strategy;Troponin;Troponin C;Troponin I;Validation;Variant;Viral

PROJECT_TITLE: Experimental and Computational Studies in Genetic Cardiomyopathies

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

PHR: Narrative Retrotransposable elements are viral-like entities that exist within the DNA of our cells. During aging these molecular parasites are prone to activation, with deleterious effects on their host cells, such as inflammation. Our goal is to develop drugs to block these elements, which we expect will alleviate age-associated diseases.

PI_NAMEs: SEDIVY, JOHN M (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Advanced Development;Age;age related;age-related disease;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Astrocytes;Biological Assay;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain cell;Cause of Death;Cell Aging;Cell Culture Techniques;Cell Nucleus;Cells;Central Nervous System;Chromatin;Chronic;Clinical;cognitive function;Complementary DNA;Complex;Cytoplasm;Data;derepression;Development;Disease;Disease Progression;DNA;drug discovery;Drug Targeting;Economics;efficacy evaluation;Elements;endonuclease;Environment;Enzymes;experimental study;extend lifespan;FDA approved;Frequencies;Frontotemporal Dementia;Generations;Genetic Transcription;Genets;Goals;hallmarks of aging;HIV;HIV Infections;Human;Human Genome;human model;human tissue;improved;Inflammaging;Inflammation;Inflammatory;inhibitor;inhibitor therapy;Innate Immune System;interest;Interferon Activation;Interferon Type I;Knowledge;L1 Elements;Lewy Body Dementia;Life Cycle Stages;life span;Link;Medical;Microglia;Modeling;Molecular;mouse model;Mus;Nature;neurodegenerative dementia;Neurodegenerative Disorders;neurodegenerative phenotype;neuroinflammation;neuronal survival;Neurons;novel;novel drug class;novel therapeutic intervention;novel therapeutics;Nuclear;Nucleosides;paracrine;Parasites;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Process;programs;Proliferating;protein TDP-43;Publishing;Reporting;Research;response;Response Generalization;Retrotransposition;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA-Directed DNA Polymerase;Role;Running;senescence;senescence associated secretory phenotype;senescent cell;sensor;Signal Transduction;Specimen;Stimulator of Interferon Genes;Stress;Structure;Structure-Activity Relationship;targeted treatment;tau Proteins;Tauopathies;therapy design;Tissues;Viral

PROJECT_TITLE: Effectors of Cellular Senescence States

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The hardware components currently used for spatial encoding, excitation, and signal reception in MRI are complex and represent a large portion of the cost and bulk of a scanner. This project will reduce the cost and complexity of MRI by developing a single integrated coil unit that performs all three of these functions, and is wireless, compact, and scalable. Arraying the units around the body and coordinating their operation using novel pulse sequences will enable rapid quantitative imaging with a wide range of magnet designs and could bring about a new generation of simple, compact, modular, and low-maintenance MRI scanners.

PI_NAMEs: GRISSOM, WILLIAM A;GRISWOLD, MARK  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Amplifiers;Brain;Brain imaging;Brain scan;Clinical;Complex;contrast imaging;cost;cost effective;Data;design;Diameter;Dictionary;Disease;experience;experimental study;Fingerprint;flexibility;Generations;Head;Heating;Human;human subject;Image;imaging modality;improved;in vivo;Lesion;Loudness;Machine Learning;magnetic field;Magnetic Resonance Imaging;Maintenance;Maps;Medical Imaging;Methods;MRI Scans;novel;operation;Output;Patients;Performance;Peripheral Nerve Stimulation;Phase;Physiologic pulse;portability;Process;Property;quantitative imaging;radio frequency;radiologist;Reader;reconstruction;Renaissance;Resolution;RF coil;Rotation;Safety;Scanning;Signal Transduction;skills;Speed;System;Technology;Thinking;Tissues;Training;Translating;transmission process;Variant;wireless;wireless transmission

PROJECT_TITLE: Gradient-Free Quantitative MRI using a Combination of B1-Selective Excitation and Fingerprinting


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Liquid-liquid phase separation recently emerged as a novel driver of skin barrier formation. Mechanistically, the underlying intracellular phase separation dynamics govern the assembly and disassembly of enigmatic keratohyalin granules, which are hallmarks of epidermal differentiation conspicuously absent in human skin barrier disorders. Deploying innovative biomolecular engineering approaches in human epidermal equivalent models, this proposal will enable the molecular-level characterization and design of functional keratohyalin granules, laying a foundation for future therapeutic manipulation of epidermal phase separation dynamics.

PI_NAMEs: AVECILLA, ALEXA REGINA CHUA (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Adult;Affect;Architecture;Atopic Dermatitis;Behavior;biochemical tools;Biotin;Biotinylation;Calcineurin inhibitor;Catalogs;Cell Nucleus;Characteristics;Child;chronic inflammatory skin;Coupling;Cytoplasmic Granules;Cytosol;Defect;design;Destinations;Disease;druggable target;Engineering;Epidermis;Event;Exons;experimental study;filaggrin;Foundations;Future;Gene Delivery;Genes;Genetic study;Genetic Variation;Goals;Health;Histidine;Human;Human Genetics;imaging approach;Immune;Immunosuppression;Impairment;Inflammation;Inflammatory;innovation;insight;keratinization;keratinocyte;keratinocyte differentiation;keratohyalin;Label;Length;Link;Liquid substance;live cell imaging;loss of function;loss of function mutation;Maps;Mass Spectrum Analysis;Membrane;Modeling;Molecular;Monoclonal Antibody Therapy;Mutation;Nature;Nonsense Mutation;novel;Organelles;Pathogenesis;Pathologic;Patients;Phase;Physical condensation;Physiological;prevent;Process;programs;Protein Engineering;Proteins;Proteomics;Recurrence;Research;restraint;Role;Skin;skin barrier;skin disorder;Skin repair;standard of care;Stratification;Stratum Granulosum;Testing;Therapeutic;therapeutic target;tool;Tyrosine;Variant;Viscosity;Work

PROJECT_TITLE: Toward therapeutic targeting of liquid-liquid phase separation dynamics in skin


NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Pain Research;Racial and Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project narrative Osteoarthritis is an enormous and increasing public health problem that, like many other chronic conditions, is not a single disease but a heterogeneous condition consisting of multiple subgroups, or phenotypes, with differing underlying mechanisms. Ultrasound is an accessible, time-efficient, and cost-effective imaging modality that provides invaluable data about all joint tissues involved in osteoarthritis and has the potential to identify important phenotypes. The proposed work is relevant to the NIAMS mission and represents a crucial step to establish the foundation for ultrasound as an assessment tool for use in clinics, research, and clinical trials in osteoarthritis.

PI_NAMEs: NELSON, AMANDA E (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;African American;African American population;Age;aged;Area;aspirate;Assessment tool;Bilateral;Biochemical;Biological Markers;bone;Bone Spur;Calcium;Cartilage;Categories;Characteristics;Chronic;Claustrophobias;Clinic;Clinical;Clinical Assessment Tool;Clinical Data;Clinical Trials;cohort;Cohort Studies;Communities;cost;cost effective;County;Crystal Formation;Data;Data Set;Degenerative polyarthritis;Development;Discrimination;Disease;effusion;Enrollment;Ethnic Origin;Etiology;follow-up;Foundations;Future;General Population;Genetic;Goals;Health;Hispanic;Image;imaging modality;Implant;Individual;individual variation;Infrastructure;interest;Intervention;Joints;Knee;Knee Osteoarthritis;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measures;men;Meniscus structure of joint;Mission;Modality;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;novel;Outcome;Pain;Participant;Pathology;Performance;Phase;Phenotype;Physical activity;point of care;Popliteal Cyst;Population;population based;Population Study;Prevalence;Public Health;Race;radiological imaging;Receiver Operating Characteristics;recruit;Research;rheumatologist;Risk Factors;sex;Sex Differences;Specialist;Standardization;Subgroup;Symptoms;Syndrome;Synovial Membrane;Synovitis;Testing;Time;Tissues;Ultrasonography;ultrasound;uptake;Variant;Woman;Work

PROJECT_TITLE: Assessment of ultrasound features of knee osteoarthritis in a population-based community cohort

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering;Wound Healing and Care

ORG_CITY: SYRACUSE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the availability of a hemostatic dressing that is easy-to-use and effective in a range of hemorrhagic wound types will reduce bleeding-associated deaths. This work will provide essential pre-clinical characterization of shape memory polymer (SMP) foams in traumatic wounds to poise their submission to the Food and Drug Administration (FDA) for clearance for clinical use. This proposed research is relevant to the NIH’s mission in that it will open new horizons in improving clinical outcomes in a range of bleed types by enhancing our understanding of hemostatic dressing effects on coagulation.

PI_NAMEs: KOLLISCH-SINGULE, MICHAELA CHRISTINA;MONROE, MARY BETH (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Affect;Aftercare;Analgesics;Animals;antimicrobial;Architecture;Biocompatible Materials;biomaterial compatibility;Blood;Body Temperature;Cellulose;Cessation of life;Chitosan;Clinical;clinical translation;clinically relevant;Coagulation Process;combat;Data;design;Device Designs;Devices;Dryness;European Union;Excision;expectation;Exposure to;Family suidae;femoral artery;Fibrin;Focal Infection;Future;Future Generations;Goals;Gunshot wound;Heating;Hemorrhage;Hemostatic Agents;Hemostatic function;High temperature of physical object;Hospitals;Hour;Human;implantation;improved;improved outcome;In Vitro;in vivo;infection risk;Injury;Japan;Limb structure;Liver;liver injury;Memory;Mission;Modeling;Monitor;Outcome;Patients;Peripheral Vascular Diseases;Polymers;Porosity;pre-clinical;pressure;Property;Public Health;remote location;Research;Safety;Shapes;Site;Sterile coverings;survival outcome;System;Techniques;Time;Tissues;Tourniquets;Training;Trauma;traumatic wound;United States;United States Food and Drug Administration;United States National Institutes of Health;Water;Work;wound;Wound models

PROJECT_TITLE: Shape Memory Polymer Foams for Hemorrhage Control in Traumatic Wounds

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Prevention;Suicide;Suicide Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Rising suicide rates are a serious public health concern, and there is an urgent need for better access to effective prevention strategies that are highly transportable across settings. The study team has shown that a single session of crisis response planning (CRP) effectively reduces suicidal behavior in high-risk groups; however, it is unknown how CRP works, and for whom, curtailing intervention optimization and widespread implementation. The current study therefore combines simultaneous, multimodal neurobiological assessments of cognitive-affective functioning with a clinical trials design to uncover neural mechanisms and predictors of changes in suicide risk following a single session of CRP.

PI_NAMEs: GORKA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adopted;Adult;Affective;Aftercare;American;Award;Behavior;Behavioral inhibition;Blinking;Brain;brain based;brain pathway;career;Cause of Death;Cessation of life;Chemosensitization;Clinical;clinical decision-making;Clinical Trials Design;Cognitive;cognitive reappraisal;cohort;comparison control;Coping Behavior;Data;data integration;Development;Distal;Ecological momentary assessment;emotion regulation;Emotional;Emotions;Feeling suicidal;follow-up;Functional Magnetic Resonance Imaging;Funding Mechanisms;Goals;Health;health care settings;high risk;high risk population;Hour;improved;indexing;Individual;innovation;Intervention;Joints;Knowledge;longitudinal design;Mediating;Medical;Mission;multimodality;National Institute of Mental Health;neural;neural circuit;neural network;Neurobiology;neuromechanism;Neurophysiology - biologic function;Neurosciences;Outcome;Outpatients;Patient Self-Report;Patients;post intervention;Prevalence;Prevention Research;Prevention strategy;preventive intervention;Primary Care;prognostic indicator;programs;psychiatric inpatient;Psychophysiology;Public Health;Randomized;Recommendation;Recording of previous events;Recovery;reducing suicide;Research;response;Risk;Risk Management;Series;Services;Signal Transduction;Soldier;Source;Strategic Planning;stress reactivity;stress reduction;success;successful intervention;suicidal;suicidal behavior;suicidal risk;Suicide;suicide model;Suicide prevention;suicide rate;support network;Surveys;System;Technology Assessment;Testing;Time;translational research program;treatment planning;United States;Volunteer Group;Work

PROJECT_TITLE: Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Patient Safety;Prevention;Primary Health Care;Suicide;Suicide Prevention

PHR: CATS (EXPLORATORY PROJECT): NARRATIVE See Project Narrative in the Overall component.

PI_NAMEs: DAVIS-MARTIN, RACHEL ELIZABETH (contact)

PROJECT_TERMS: Acceleration;Active Learning;Address;Administrator;Adoption;Adult;Ambulatory Care Facilities;Anxiety;base;Behavior;behavioral health;Caring;Cause of Death;Cellular Phone;Cessation of life;Clinic;Clinical;clinical decision support;clinical decision-making;clinical practice;Collaborations;Communication Tools;Communities;computerized;cost;Coupling;dashboard;Data;design;Detection;Development;Economics;effective intervention;Electronic Health Record;Ensure;Environment;Ethics;Evidence based practice;experience;Family;feasibility testing;Feeling suicidal;Funding;Health Insurance Portability and Accountability Act;Healthcare;Hylobates Genus;implementation measures;implementation science;implementation strategy;implementation trial;improved;Individual;informant;innovation;Insurance Carriers;Intervention;Interview;Joints;Life Expectancy;Medical;Mental Depression;Mental Health;Mental Tests;Modality;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Mental Health;novel;Pathway interactions;Patient Education;patient health information;patient portal;Patients;Persons;Point of Care Technology;Population;prevent;Primary Care;primary care clinic;primary care practice;primary care provider;primary medical care;Privacy;Procedures;Provider;psychiatric symptom;Public Health Informatics;Publishing;Recommendation;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Sampling;screening;simulation;Site;Specialist;Standardization;Substance abuse problem;success;suicidal risk;Suicide;Suicide prevention;Symptoms;System;Tablets;Techniques;Technology;Test Result;Testing;Thinness;Time;Translating;translational barrier;Translations;trend;United States;Update;uptake;usability;user centered design;validation studies;Variant;Vendor;Visit;visual tracking;Work

PROJECT_TITLE: Exploratory Research Project - CAT


ADMINISTERING_IC: LM

ED_INST_TYPE: LIBRARIES

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE – Overall, NNLM Region 5 RML/University of Washington The University of Washington, Reaching More People in More Ways, operates the Regional Medical Library for the Network of the National Library of Medicine Region 5 in the states of Alaska, California, Hawaii, Nevada, Oregon, and Washington and U.S. Territories and Freely Associated States in the Pacific. Region 5 works with six other regional programs to advance data driven health, health equity, and health literacy by offering NNLM services, engagement, funding, and training opportunities. Members continuously learn about National Library of Medicine resources and participate in national and regional collaborations and partnerships to support a highly trained workforce to access biomedical and health information resources and data, improve health literacy, and increase health equity.

PI_NAMEs: MUILENBURG, JENNY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Acceleration;Address;advocacy organizations;Alaska;Award;Bioinformatics;biological sex;California;Cognitive;Collaborations;Communities;Community Health;Competence;Complex;COVID-19;Data;data literacy;demographics;Development;Diffuse;digital;Education;Educational process of instructing;Educational Status;Emergency Situation;Equity;Ethnic Origin;first responder;Food;Free Association;Funding;Funding Opportunities;gender expression;Gender Identity;Geographic Locations;Geography;Hawaii;Health;health equity;health literacy;Health Professional;Health Status;Housing;improved;Information Resources;Information Services;innovation;learning progression;Librarians;Linguistics;Medical Libraries;Medically Underserved Area;member;Nevada;Oregon;outreach;Persons;programs;Public Health;Race;Religion;Research;Research Personnel;Resources;Role;Services;Sex Orientation;Sexual and Gender Minorities;Socioeconomic Status;Technology;Time;Training;training opportunity;Underrepresented Populations;Unemployment;United States National Library of Medicine;Universities;Vulnerable Populations;Washington;Work

PROJECT_TITLE: NNLM Region 5:  Reaching More People in More Ways


PI_NAMEs: BARDYN, TANIA P (contact)

PROJECT_TERMS: Access to Information;Accountability;Accreditation;Administrator;Alaska;Award;biomedical informatics;Budgets;Businesses;Collaborations;Committee Members;community organizations;Data;Decision Support Systems;design;Development;Emergency Situation;Equity;Evaluation;experience;Funding;Goals;Grant;Hawaii;Health;Health Science Library;Human Resources;Institution;inter-institutional;Leadership;leadership development;Libraries;Los Angeles;Measures;Mediation;Medical Education;Medical Libraries;medical schools;Medicine;member;Modeling;Nevada;outreach;parent grant;Performance;Personnel Management;Persons;Policies;Privatization;Problem Solving;Professional Organizations;professor;Program Development;programs;Readiness;recruit;Reporting;Research;Resources;response;Series;Services;Structure;success;System;Target Populations;tool;Training;U-Series Cooperative Agreements;United States National Library of Medicine;Universities;Washington


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative We discovered a previously unrecognized mechanism by which neurons protect against effects of protein aggregation—they physically throw out their threatening trash in membrane-surrounded large vesicles (exophers) for uptake by remote cells. “Exopher-genesis” is increased when neurons are subjected to proteostasis challenges, including expression of human Alzheimer's disease fragment A 1-42. Since we propose that exopher-genesis is a conserved pathway for maintaining neuronal health and we speculate that older age dysfunction of the exopher pathway might contribute to neurodegeneration and spread of neurotoxic species, dissection of the exopher mechanism should provide novel insight on Alzheimer's disease-relevant pathology that might be manipulated for therapeutic benefit.

PI_NAMEs: DRISCOLL, MONICA A. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: ABI2 gene;Address;Adult;Affect;Age;age effect;age related decline;Aging;aging brain;aging population;Alzheimer's Disease;Animal Model;Animals;Area;Autophagocytosis;Basic Science;Biological Models;Biology;Brain;Caenorhabditis elegans;Cell Maintenance;Cells;Cellular biology;Chronology;clinical development;Data;Disease;Dissection;Distant;Elderly;Elements;extracellular;Functional disorder;Genes;Genetic;genetic manipulation;genome wide association study;Goals;Health;healthy aging;Homologous Gene;Human;human disease;human old age (65+);Human Pathology;Impairment;in vivo;Individual;insight;Intervention;knock-down;Label;Life;life span;Longevity;longevity gene;Maintenance;Mammals;Membrane;Microscope;middle age;misfolded protein;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;multicatalytic endopeptidase complex;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuronal cell body;Neuronal Dysfunction;Neurons;neuroprotection;neurotoxic;novel;Orthologous Gene;Outcome;overexpression;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Physiological;Play;polyglutamine;Population;Process;Production;protein aggregation;Protein Biosynthesis;protein folding;Proteins;proteostasis;proteotoxicity;Publishing;Quality Control;response;RNA Interference;Role;Route;screening;segregation;Stress;Structure;System;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;Transgenes;uptake;Vesicle;Visualization;Work

PROJECT_TITLE: Defining roles of genetic and age in extracellular elimination of neurotoxic aggregates


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: ADAPT (EXPLORATORY PROJECT): NARRATIVE See Project Narrative in the Overall component.

PI_NAMEs: LIU, FEIFAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;advanced analytics;Age;age group;Algorithms;Big Data;Caring;Clinic;Clinical;clinical data repository;clinical diagnosis;clinical practice;clinical predictors;cohort;Complex;Comprehensive Health Care;Data;Data Collection;data integration;data modeling;Data Scientist;Data Set;Data Sources;deep learning;deep neural network;design;Development;Disparity population;effective intervention;Effectiveness;Electronic Health Record;Environment;Equity;ethnic minority;Ethnic Origin;Evaluation;evidence base;Feedback;Follow-Up Studies;Foundations;Funding;Health;health care delivery;health care service;Health Care Visit;health disparity;Health Promotion;Health system;Healthcare;Healthcare Systems;heterogenous data;high risk;high risk population;human-in-the-loop;implementation facilitators;improved;Individual;informatics tool;innovation;Institution;Insurance Coverage;interest;Intervention;Knowledge;Learning;learning progression;Machine Learning;machine learning prediction algorithm;Manuals;Maps;marginalized population;medical schools;medical specialties;Mental Health;model generalizability;Modeling;Mood Disorders;National Institute of Mental Health;Organizational Affiliation;patient population;Patients;Performance;pilot test;predictive modeling;predictive tools;Prevention;Prevention Research;Primary Care;Process;Prognosis;Race;racial minority;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;risk prediction model;sex;social disparities;Socioeconomic Status;Subgroup;success;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Techniques;Technology;Testing;Time;Training;Translating;Translations;United States;usability;Use Effectiveness;Validation;Visit;Work

PROJECT_TITLE: Exploratory Research Project - ADAPT


PROJECT_TERMS: Address;Award;Collaborations;Communities;Data;data tools;Education;Education and Outreach;Ensure;Evaluation;Funding;Future;Health;health data;health equity;health literacy;Health Personnel;Health Professional;improved;Information Resources;Intervention;Leadership;Libraries;Medical Libraries;member;Mission;outreach;Persons;programs;Public Health;Research;Research Personnel;Technology;Training;Underrepresented Populations;United States National Library of Medicine;Universities;Washington

PROJECT_TITLE: NNLM Region 5: Reaching More People in More Ways