NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Neurosciences;Radiation Oncology;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: When cancer cells grow, invade and migrate along nerves in either the central (CNS) or peripheral nervous system (PNS), it results in the worst outcomes for patients yet there is very little knowledge about this process and no effective treatments. We hypothesize that a biomarker resulting from proteolysis of a cell-cell adhesion molecule can be utilized to detect and treat cancer growth along nerves in both the CNS and PNS. Here, we seek to enhance detection and treatment by developing a tumor-specific biomarker targeted theranostic agent that selectively enhances radiosensitization of primary, invasive, and metastatic breast cancer to the brain for improved radiation therapy.

PI_NAMEs: BASILION, JAMES PETER;BRADY-KALNAY, SUSANN M (contact)

PROGRAM_OFFICER_NAME: ESPEY, MICHAEL G

PROJECT_TERMS: 3-Dimensional;Adhesions;Affinity;Architecture;Area;axon guidance;Binding;Biological Markers;Biology;Brain;Brain Neoplasms;brain tissue;Breast;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;Carcinoma;Cell Adhesion;Cell Adhesion Molecules;cell motility;Cell-Adhesion Molecule Receptors;Cell-Cell Adhesion;Cells;Central Nervous System;chemokine;Complex;Cues;Detection;Development;Diagnostic Imaging;Disparate;Drug Delivery Systems;effective therapy;Engineering;Exhibits;extracellular;fluorescence imaging;fluorophore;Gold;Growth;Growth Factor;Human;Image;Image Analysis;imaging biomarker;imaging capabilities;imaging modality;imaging system;improved;in vivo;Individual;insight;Invaded;Invasive Lesion;Knowledge;Label;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic breast cancer;Metastatic malignant neoplasm to brain;migration;Modeling;Molecular;mouse model;Multimodal Imaging;Mus;nanoGold;nanoparticle;Neoplasm Metastasis;neoplastic cell;Nerve;Nervous System;neural;Neural Crest Cell;Neurites;neurodevelopment;Neurons;Neurosciences;novel;novel marker;orthotopic breast cancer;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Peptide Hydrolases;perineural;Peripheral Nervous System;Post-Translational Protein Processing;Process;Prognosis;Protein Tyrosine Phosphatase;Proteolysis;Radiation;Radiation Dose Unit;Radiation therapy;Radiosensitization;receptor;Regulation;Research;Resistance;Resolution;Route;Signal Transduction;Solid Neoplasm;standard of care;stem;Structure;targeted agent;targeted biomarker;targeted treatment;Testing;theranostics;Therapeutic;therapy outcome;Tissues;Treatment Efficacy;tumor;Tumor Cell Invasion;Tumor Cell Migration;tumor growth;Tumor Markers;tumor microenvironment;Tumor Promotion;Tumor Tissue;white matter;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Detection, Radiosensitization and Theranostic Targeting of Metastatic Breast Cancer by PTPmu

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The proposed research addresses a critically important question in autism spectrum disorder (ASD) research: how defects in cerebellar circuits contribute to ASD. Neurogenetic studies demonstrate that CNVs in the predominantly cerebellar gene ASTN2 are a significant risk factor for ASD. The proposed research will use a novel mouse model lacking Astn2 that we generated to analyze changes in cerebellar circuit function, synaptic proteins, organization of synaptic inputs and ASD-related changes in social behavior and communication.

PI_NAMEs: HATTEN, MARY ELIZABETH (contact);HULL, COURT A

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acute;Address;adhesion receptor;Adhesions;Animals;autism spectrum disorder;behavior test;Behavioral;Binding;Biological Assay;Brain;Cell membrane;Cells;Cerebellar Cortex;Cerebellum;conditional knockout;Copy Number Polymorphism;CRISPR/Cas technology;Defect;Dendritic Spines;density;design;Development;Distal;Electrophysiology (science);Endocytosis;experimental study;Family;Fiber;Frequencies;Genes;Genetic Models;granule cell;Grooming;Heterozygote;Image;In Vitro;Inherited;insight;Interneurons;Ion Channel;Language Delays;Lead;Learning Difficulty;Lifestyle-related condition;Link;loss of function;Loss of Heterozygosity;LoxP-flanked allele;Mass Spectrum Analysis;Measurement;Measures;Membrane Proteins;model of autism spectrum disorder;Molecular;motor deficit;mouse model;Mus;mutant;Mutation;Neurodevelopmental Disorder;neurogenetics;novel;open field behavior;overexpression;Pathway interactions;Patients;Physiological;postsynaptic;presynaptic;Protein Dynamics;protein transport;Proteins;Proteome;Proteomics;Purkinje Cells;receptor;Reporting;Research;Reversal Learning;Risk Factors;Role;Sensory;Slice;Smell Perception;social;Social Behavior;social communication;Speech Delay;Synapses;synaptic function;Testing;trafficking;Ultrasonics;Vertebral column;Vesicle;vocalization;Work

PROJECT_TITLE: Role of ASTN2 in Cerebellar Circuit Function and ASD-related Behaviors

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Our study will help to gain insights into molecular and cellular mechanisms of PFAS exposure on the developing brain using human stem cell derived experimental models. It will also identify genes that are dysregulated by PFAS compounds.

PI_NAMEs: IAKOUCHEVA, LILIA M (contact);MUOTRI, ALYSSON R.

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Animals;Astrocytes;ATAC-seq;Attention deficit hyperactivity disorder;autism spectrum disorder;behavioral phenotyping;Biological;Blood - brain barrier anatomy;Blood specimen;Brain;Carbon;Carboxylic Acids;Carpet;Cell Cycle;Cell Differentiation Induction;Cell Proliferation;Cell Survival;Cells;Chemicals;Chromatin;Clothing;Complex;CRISPR interference;Detection;Development;Developmental Delay Disorders;developmental toxicity;differential expression;Disease;Dose;early pregnancy loss;Environment;Environmental Risk Factor;excitatory neuron;exome;Experimental Models;exposed human population;Family;Fetal Development;Fluorine;Food;gene discovery;Genes;Genetic;genetic risk factor;Genetic Screening;Genetic Transcription;genome sequencing;genome wide association study;genome-wide;Glutamates;Growth;Half-Life;Head circumference;High Prevalence;Human;Human Development;human induced pluripotent stem cells;human stem cell-derived;Hyperactivity;in vitro Model;induced pluripotent stem cell;Industrialization;insight;Knowledge;lentivirally transduced;Libraries;Literature;Low Birth Weight Infant;Machine Learning;man;Microcephaly;Modeling;Molecular;Morphology;Mothers;multi-electrode arrays;Mus;nerve stem cell;neural network;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurons;offspring;Organoids;Paper;Pathway interactions;Phenotype;Placenta;Play;Poly-fluoroalkyl substances;Population;postnatal;Prevalence;Problem behavior;progenitor;programs;Proliferating;rare variant;Rattus;Reporting;Role;Schizophrenia;Serum;single-cell RNA sequencing;spheroids;stem cell model;Sulfonic Acids;Testing;Time;Toxic effect;transcriptome sequencing;transcriptomics;Umbilical Cord Blood;variant detection;whole genome;Zebrafish

PROJECT_TITLE: Investigating neurodevelopmental toxicity of perfluoroalkyl acids and their derivatives in human brain organoids models


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Immunotherapy;Microbiome

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Colorectal cancer remains a common and deadly disease that is on the rise amongst young people worldwide. Colon tumors grow adjacent to the intestinal microbiome and bacteria from the microbiome can both drive tumor growth and also support the activation of anti-tumor immunity. Our proposal seeks to identify colonic bacteria that most activate colonic immune cells and define how immune cells become activated to kill tumors.

PI_NAMEs: HAND, TIMOTHY WESLEY (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: anti-tumor immune response;Antibodies;Antibody Formation;Antigen Presentation;Antitumor Response;B-Lymphocytes;Bacteria;Behavior;C57BL/6 Mouse;Cancer Etiology;cancer type;CD4 Positive T Lymphocytes;Cell Communication;Cells;Cessation of life;Colitis associated colorectal cancer;Colon;colon bacteria;colon cancer patients;colon microbiota;Colonic Neoplasms;Colorectal;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Dendritic Cells;Development;Disease;Epithelium;Failure;Genes;Growth;gut microbiome;Helicobacter;Helicobacter hepaticus;Helper-Inducer T-Lymphocyte;Home;Human;Immune;Immune response;Immunity;immunogenic;Immunotherapy;improved;Incidence;Inflammation;intestinal epithelium;Intestines;Invaded;Knock-out;Location;Malignant Neoplasms;Measures;Mediator;Melanoma;MHC Class II Genes;microbiome;microbiome composition;microbiota;microbiota composition;Microsatellite Instability;model development;Modeling;mouse model;Mucous body substance;murine colitis;Mus;Natural Killer Cells;neoplasm immunotherapy;NK Cell Activation;Outcome;Patient-Focused Outcomes;Patients;Persons;Property;Rectal Cancer;Rectal Neoplasms;Sampling;Shapes;Structure;Structure of germinal center of lymph node;T cell differentiation;T-Lymphocyte;Taxon;tertiary lymphoid organ;Testing;Therapeutic;tumor;Tumor Antigens;Tumor Burden;tumor growth;Tumor Immunity

PROJECT_TITLE: Identifying the mechanism of anti-colorectal immunity induced by mucoinvasive colonic bacteria

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The type and pattern of immune cell infiltrate in breast cancer is of growing clinical importance as they associate with response to therapy and are the specific target of immunotherapy. However, the factors that influence the genesis of the type of tumor immune microenvironment (TiME) have yet to be defined. Our proposed systematic, mechanistic, high content analysis and modeling of the cellular and molecular mechanisms by which breast cancers evade the immune system focuses on will elucidate key factors that govern the origins of the TiME.

PI_NAMEs: BARCELLOS-HOFF, MARY HELEN (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Affect;Aftercare;Age;Aging;Anti-Inflammatory Agents;anti-tumor immune response;Aspirin;biobank;Bioinformatics;Biology;Blood;Bone Marrow;BRCA1 gene;Breast Cancer Patient;Breast Cancer Risk Factor;cancer immunotherapy;carcinogenesis;Cell model;Cells;Characteristics;Chimera organism;Chronic;Clinical;clinically significant;Communities;conditional knockout;cyclooxygenase 2;cytokine;Data;deep learning;deep learning model;Development;Distal;Dose;Event;Exhibits;experimental study;Germ-Line Mutation;Goals;high risk population;Histologic;Hodgkin Disease;Immune;immune cell infiltrate;Immune system;immunoregulation;Immunotherapy;Infiltration;Inflammation;innovation;Lymphocyte;Lymphocytic Infiltrate;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Tumorigenesis;Methods;Modeling;molecular modeling;monocyte;Mus;Myeloid Cells;Natural Immunity;Nature;neoplasm resource;Non-Malignant;novel;Obesity;Outcome;Parabiosis;Pattern;Phenotype;Plasma;Population;pregnancy-associated breast cancer;Publishing;Radiation;Radiation therapy;Recording of previous events;Reporter;response;Role;Second Primary Cancers;Signal Transduction;Spleen;Stress;Syndrome;systemic inflammatory response;T cell infiltration;Testing;Tissues;Transforming Growth Factor beta;Transplantation;treatment response;tumor;Tumor Escape;Tumor Immunity;Tumor Subtype;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Virus Diseases;Woman;women's treatment

PROJECT_TITLE: Investigating the Genesis of Tumor Immune Microenvironment (TIME) as a function of Inflammation

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE New therapeutic approaches are urgently needed to improve the treatment of metastatic prostate cancer, which is the second leading cause of cancer death in American men. The goal of this proposal is to develop a new mechanism-based therapy to improve the antitumor efficacy and sustainability of enzalutamide. Since enzalutamide is widely used in metastatic PCa, the results of this proposal will have significant and broad impact.

PI_NAMEs: QIAN, ZHENG DAVID  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Alanine Transaminase;alpha ketoglutarate;American;androgen independent prostate cancer;androgen sensitive;Androgens;Animal Model;anti-cancer;Antibiotics;Biochemical;Biological;Biology;Biopsy Specimen;Cancer Etiology;candidate marker;Castration;Cell model;Cell Proliferation;Cell Survival;Cessation of life;Clinical;Clinical Trials;clinically relevant;CRISPR/Cas technology;Cycloserine;Data;deprivation;Disease;Disease Outcome;Disease Progression;enzalutamide;Fatty Acids;Genetic Transcription;Glutamates;Glutamine;Goals;Growth;Human;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;Knowledge;Life;lipid biosynthesis;Lipids;loss of function;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Metabolic;Metabolism;Metastatic Prostate Cancer;Methods;Molecular;Mus;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Play;pre-clinical;preclinical efficacy;programs;prostate cancer cell;prostate cancer model;prostate cancer progression;Proteins;Resistance;Resistance development;response;Role;Sampling;Series;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Tissue Sample;Transaminases;treatment response;treatment strategy;tumor;Xenograft procedure

PROJECT_TITLE: Developing therapies to improve enzalutamide in CRPC

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This study aims to reveal the previously unappreciated cell type, TFR cells, as a cancer prognostic marker and the IgE response as a predictor to the disrupted TFR cell function. This study will also illustrate how adaptive immunity interplays with innate responses contributing to tumor evolution. If successful, this study would advance our fundamental mechanistic understanding of tumor immunology and lead to a new direction for cancer immunotherapy.

PI_NAMEs: LEAVENWORTH, JIANMEI WU (contact)

PROJECT_TERMS: Acidity;Activities of Daily Living;adaptive immunity;Affinity;Antibody Response;B-Lymphocytes;biobank;cancer immunotherapy;Cancer Patient;Cell Physiology;cell type;Cells;Clinical;clinically significant;contrast enhanced;Coupled;defined contribution;Deposition;Development;digital;Economics;effector T cell;Evolution;Flow Cytometry;fluorescence molecular tomography;FOXP3 gene;Freezing;Frequencies;Gene Modified;Goals;Human;Hydrogen;Hypoxia;IgE;immune checkpoint blockade;Immune system;Immunofluorescence Immunologic;immunogenicity;Impairment;improved;insight;Macrophage;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Mediating;Melanoma;Modeling;Mus;neoplasm immunotherapy;Neoplasm Metastasis;new therapeutic target;NHE1;Outcome;patient prognosis;PD-1 blockade;Peripheral Blood Mononuclear Cell;Population;Positron-Emission Tomography;PRDM1 gene;predictive marker;Prognostic Marker;programs;Public Health;receptor;Regulation;Regulatory T-Lymphocyte;Reporting;Repression;response;Risk;Role;Secondary to;Self Tolerance;Serum;Shapes;single-cell RNA sequencing;Sodium;spatial relationship;Specimen;Stains;Structure of germinal center of lymph node;T-cell receptor repertoire;T-Lymphocyte Subsets;tertiary lymphoid organ;Testing;therapeutically effective;therapy outcome;Tissues;tomography;transcription factor;tumor;Tumor Escape;Tumor Expansion;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Tumor-Infiltrating Lymphocytes;Up-Regulation;X-Ray Computed Tomography

PROJECT_TITLE: Follicular Regulatory T-cells Promote Cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative  The mission of the 4th Annual Immune Modulation and Engineering symposium, which will be held at Drexel University on Dec. 7-9, 2022, is to bring together researchers in biomedical engineering and basic and translational immunology to advance the rapidly emerging field of immune engineering. The speakers and attendees represent leaders in this field, with expertise in collaborating across disciplines to generate innovative solutions to treat cancer, infectious disease, immunological disorders and major injuries by modulating the immune system.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Biomedical Engineering;cancer cell;career;Caring;Child;clinical translation;Collaborations;Communicable Diseases;Communities;disability;disadvantaged background;Discipline;Disease;Disparity population;Engineering;Ethnic Origin;Event;Family;Future;Gender;Goals;Immune;Immune system;Immune System Diseases;immunoengineering;immunoregulation;industry partner;Infant;Injury;innovation;innovative technologies;Location;Malignant Neoplasms;Mission;Molecular;nanomedicine;new technology;next generation;Patient Recruitments;Philadelphia;Publishing;Regenerative Medicine;Research;Research Personnel;Resources;Science;Scientist;Series;success;Surveys;symposium;synthetic biology;Tissue Engineering;translational immunology;tumor immunology;Underrepresented Populations;Universities

PROJECT_TITLE: Immune Modulation & Engineering Symposium


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This study has the potential to positively impact care for older adults with Alzheimer’s Disease and related dementias (ADRD) in rural areas by improving the communication and coordination of those involved in caring for and supporting these older adults and their caregivers. It will do so by identifying gaps in the communication and coordination of ADRD care in two rural areas then selecting and pilot testing, in collaboration with community partners, a health information technology tool to support the communication and coordination of ADRD care in the area. This work is strongly aligned with the NIA’s goal to “understand health disparities and develop strategies to improve the health status of older adults in diverse populations” and specifically addresses a priority population in the NIA’s Health Disparities Framework.

PI_NAMEs: PRUSACZYK, PATRICIA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: acceptability and feasibility;Address;Affect;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;care coordination;care systems;Caregivers;Caring;Case Manager;Characteristics;clinical decision support;Collaborations;Communication;Communities;community collaboration;community partners;Consultations;COVID-19 pandemic;Data;Dementia;dementia care;design;Diagnosis;Discipline of Nursing;Disease;Disparity;Doctor of Philosophy;Education;Electronics;evidence base;experience;Failure;follow-up;Future;Goals;Health;Health Disparities Research;health disparity;health information technology;Health Services;Health Services Research;Health Status;Health system;Hospitals;improved;Informatics;Information Networks;innovation;Knowledge;medical schools;medical specialties;Medication Management;Mentored Research Scientist Development Award;Mentorship;Methods;mobile application;Modeling;network models;older adult;Pathway Analysis;Patients;Pattern;pilot test;Population;Population Heterogeneity;Primary Care;primary care provider;Process;Provider;provider communication;Public Health;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resources;Risk;Rural;rural area;rural disparities;Rural Health Services;rural setting;Services;skills;social service provider;Social Work;System;Technology;telehealth;Testing;tool;Training Activity;United States;Universities;urban area;usability;Washington;web site;Work

PROJECT_TITLE: Improving Alzheimer's Disease and Related Dementias Care in Rural Areas

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: To solve the most challenging public health issues, as well as address health disparities and inequalities, the scientific community needs a diverse set of investigators to contribute to creative solutions. Retention of highly skilled scientists from underrepresented and minoritized groups (URMGs) is critical to this effort; hence, the BRAINS program offers a novel professional development program that addresses known factors impacting persistence and career decisions of individuals from URMGs in science. BRAINS serves assistant professors and postdoctoral scholars from underrepresented backgrounds to increase their likelihood of thriving and achieving success in academic neuroscience while also supporting them as they develop into future leaders in their research field.

PI_NAMEs: MIZUMORI, SHERI J. Y. (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Adoption;Attention;Black race;Capital;career;cohort;Communities;community engagement;Creativeness;Data;Development;Disabled Persons;Doctor of Philosophy;Educational workshop;Elements;Eligibility Determination;empowerment;ethnic identity;Evaluation;experience;Foundations;Future;Growth;health disparity;health inequalities;improved;Individual;Institutional Policy;instrument;interest;Interview;Lead;Leadership;marginalized population;Measures;member;Mentors;Minority Groups;Neurosciences;novel;Outcome;Participant;participant interview;Pathway interactions;patient engagement;peer;peer coaching;Persons;Policies;Positioning Attribute;Postdoctoral Fellow;professor;Program Development;programs;Public Health;racial identity;Research;Research Personnel;Resources;response;Science;Scientist;Self Efficacy;Senior Scientist;Series;Shapes;skills;success;Surveys;symposium;tenure track;Time;Time Management;Underrepresented Populations;virtual;Visit;Work

PROJECT_TITLE: BRAINS: Broadening the Representation of Academic Investigators in NeuroSciences - A national program to increase the advancement of neuroscience researchers from diverse backgrounds


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

PHR: PROJECT NARRATIVE It is very difficult for nurses using current monitoring methods to know which patients will deteriorate and when they will do so. This leads to imprecise nursing surveillance, delayed care escalation, and failure-to-rescue—an important public health concern. This is especially true outside of intensive care units where surveillance is less. We propose to expand on our prior work on machine learning models that continuously process complex data from disparate sources to design and deploy in real-time an intelligent decision support system at the bedside. Building such a system in clinical workflow and prospectively validating its clinical utility constitutes a tangible move toward precision nursing surveillance, shifting nursing care from reactive to preemptive, in turn saving lives and healthcare dollars, and improving productivity.

PI_NAMEs: AL-ZAITI, SALAH S;CLERMONT, GILLES  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Adverse event;Architecture;Beds;Benchmarking;California;care delivery;Care given by nurses;Caring;Cessation of life;Classification;Clinical;clinical research site;Clinical Trials;clinically actionable;clinically relevant;complex data;Data;Data Set;data streams;Databases;Decision Support Systems;design;Detection;detection platform;Deterioration;Diagnostic;digital;Discipline of Nursing;Disparate;effectiveness trial;electronic health database;Electronic Health Record;Engineering;Evaluation;Event;Expert Systems;Failure;Fatigue;field study;Frequencies;Funding;Future;graphical user interface;Health;Healthcare;Heart;Hospitalization;Hospitals;Human;implementation barriers;improved;innovation;Intensive Care;Intensive Care Units;Intervention;iterative design;Lead;lead optimization;Link;Logistics;Machine Learning;machine learning algorithm;machine learning classifier;machine learning model;Methods;model building;Modeling;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;novel strategies;Nurses;patient safety;Patient-Focused Outcomes;Patients;Phenotype;Physiological;predictive modeling;Predictive Value;prevent;Prevention;Process;Productivity;prospective;prototype;Public Health;Readiness;Recommendation;Risk;Risk Estimate;risk prediction;San Francisco;Series;signal processing;Signal Transduction;Site;Source;System;Testing;Time;tool;Translating;treatment response;trend;Triage;Universities;usability;user centered design;Validation;Work

PROJECT_TITLE: Predicting Patient Instability Noninvasively for Nursing Care – Three (PPINNC-3)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative T cell exhaustion is one of the main reasons that lead to immune dysfunction in chronic infection or cancer. Investigating the molecular mechanisms of T cell exhaustion will increase our understanding of T cells response during chronic infection or cancer progression. This will potentially lead to the development of optimal therapeutic strategies for the patients under immune therapies, or the discovery of new drug targets that can enhance T cell response in clinic.

PI_NAMEs: CHEN, ZEYU  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affect;anti-PD-1;anti-tumor immune response;Antigens;Antitumor Response;Bioinformatics;Biological Process;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Chronic;chronic infection;Clinic;Clinical;clinical remission;Clonal Expansion;Combined Modality Therapy;conditional knockout;CRISPR screen;CRISPR/Cas technology;CTLA4 gene;cytokine;cytotoxic;Databases;Decision Modeling;design;Development;Disease remission;Drug Targeting;Effector Cell;effector T cell;enhancing factor;Epigenetic Process;exhaust;exhaustion;experience;Foundations;Future;Gene Expression;Gene Expression Profiling;Genetic;Genetic Transcription;genomic platform;Goals;Heterogeneity;high dimensionality;high throughput screening;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immune System Diseases;Immunotherapy;improved;in vivo;Infection;Knockout Mice;Knowledge;Macrophage;Malignant Neoplasms;Memory;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Outcome;overexpression;Pathologic;Patients;Phase;Play;Population;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;prevent;Process;programmed cell death protein 1;programs;receptor;Regulatory T-Lymphocyte;Reporter;Research;response;Role;single-cell RNA sequencing;stem cell population;stem cells;success;System;T cell differentiation;T cell response;T-Cell Development;T-Lymphocyte;Technology;Therapeutic;Training;transcription factor;tumor;tumor microenvironment;tumor progression;Viral;Virus Diseases;Work

PROJECT_TITLE: Investigating molecular mechanism of immune response during cancer progression


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE – Overall Component As one of the first eight Comprehensive Cancer Centers to receive the NCI designation in 1973, the University of Southern California Norris Comprehensive Cancer Center (NCCC) is a leader in cancer research, education, and patient-centered oncology care. A central priority for NCCC is to serve the unique cancer-related needs of our multicultural catchment area, Los Angeles County. Our geographic location in the 4th most diverse city in the nation affords opportunities for NCCC to lead in bi-directional community engagement, innovative training programs, and high impact research to address cancer burdens and disparities among diverse communities.

PI_NAMEs: LERMAN, CARYN  (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Accounting;Achievement;Address;anti-cancer research;Applications Grants;Basic Science;biobank;Biological Markers;biomedical informatics;California;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer genomics;cancer health disparity;cancer prevention;Cancer Science;Caring;Catchment Area;Cell Line;Cities;Clinic;Clinical;Clinical Sciences;Clinical Trials;cohesion;Collaborations;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;County;COVID-19;COVID-19 pandemic;Cyclic GMP;Data Science;Decision Making;Detection;Development;Direct Costs;Economically Deprived Population;Education;Education and Outreach;Enrollment;Ensure;Epidemiology;Evaluation;Fostering;Funding;Genome;genomic platform;Genomics;Geographic Locations;Goals;Grant;Growth;Height;Immunotherapy;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Intervention;Intervention Trial;Investments;Laboratories;Lead;Leadership;life span;Los Angeles;Malignant Neoplasms;member;Minority;Mission;Modeling;Molecular;Monitor;mouse model;NCI Center for Cancer Research;neoplasm resource;next generation;novel;Oncology;patient oriented;Patients;Peer Review;Persons;Population;Population Heterogeneity;Population Research;Population Sciences;pre-clinical;Process;Productivity;programs;Protocols documentation;Publications;recruit;Request for Applications;Research;Research Personnel;Resource Sharing;Resources;Schools;Science;Scientist;Services;socioeconomic disadvantage;Special Population;Strategic Planning;success;survivorship;Talents;Technology;Textiles;Therapeutic Clinical Trial;Therapeutic Intervention;Training;Training and Education;Training Programs;Translations;Underrepresented Populations;underserved community;Universities;Vision

PROJECT_TITLE: University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Administrative Coordination;anti-cancer research;Award;Basic Science;Biostatistics Shared Resource;Budgets;Businesses;California;Cancer Center;Cancer Center Support Grant;cancer research center director;Cancer Science;Catchment Area;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Complement;Complex;Comprehensive Cancer Center;County;COVID-19 pandemic;Data;Data Science;Dedications;design;Doctor of Philosophy;drug development;Education;Educational Activities;Electronic Mail;Ensure;Equipment;Evaluation;Event;Faculty;Faculty Recruitment;Fostering;Funding;Future;Gifts;Goals;Grant;Guidelines;Human Resources;improved;Informatics;Information Technology;Infrastructure;innovation;Investments;Last Name;Leadership;Los Angeles;Malignant Neoplasms;meetings;member;Mission;Names;NCI Center for Cancer Research;operation;Outcome;Patients;Peer Review;Policies;Population Research;Positioning Attribute;pre-clinical;Preparation;Process;Productivity;programs;Publications;Ramp;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Science;Services;Shapes;social media;square foot;Strategic Planning;Structure;System;tool;Training and Education;Translational Research;Universities;University adminstration;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: ELLISON INSTITUTE, LLC

PHR: PROJECT NARRATIVE The 5-year survival rate for metastatic colorectal cancer (CRC) remains at 11% despite the introduction of novel therapies. Preclinical models that more closely recapitulate the human pathophysiology of CRC are needed to better understand tumor progression and chemoresistance. Our objective is to develop and characterize a microengineered CRC-on-Chip model using patient biopsy material to identify key factors in the tumor microenvironment that influence cell behavior and treatment response, with an ultimate goal of developing innovative treatment strategies effective in CRC that focus on disrupting tumor-stromal interactions.

PI_NAMEs: MUMENTHALER, SHANNON MICHELLE (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;anti-cancer research;Automobile Driving;behavioral response;biobank;Biochemical;Biological Assay;Biological Models;Biomimetics;Biopsy;Blood Vessels;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cell behavior;Cell Death;Cell Proliferation;cell type;Cells;Cessation of life;Cetuximab;Characteristics;Chemoresistance;Clinical;clinical material;Coculture Techniques;Collaborations;Colon;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Combination Drug Therapy;confocal imaging;Data;Death Rate;design;Digestion;Disease;drug development;drug efficacy;Drug Monitoring;Drug Screening;Elements;Endothelium;Engineering;Environment;Epidermal Growth Factor Receptor;Epithelium;Fibroblasts;fluid flow;Fluorouracil;Functional disorder;Gene Expression Profile;Goals;Heterogeneity;Human;human disease;Image;improved;in vivo;innovation;insight;Invaded;irinotecan;Knowledge;Leucovorin;Malignant Neoplasms;Mass Spectrum Analysis;Measures;mechanical force;Mechanics;Membrane;metabolomics;metastatic colorectal;Microfluidic Microchips;Microfluidics;microphysiology system;migration;Modality;Modeling;Motion;multidisciplinary;mutant;neoplastic cell;new therapeutic target;novel;novel therapeutics;Nutrient;Organ;organ on a chip;Organoids;Pathway interactions;Patients;Periodicity;Peristalsis;Pharmaceutical Preparations;Phenotype;Physiological;Porosity;Positioning Attribute;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;prevent;Proliferating;Research Personnel;response;Role;Sampling;screening;shear stress;standard of care;Stretching;Stromal Cells;Stromal Neoplasm;Survival Rate;System;targeted treatment;Technology;Testing;Therapeutic;Tissue Engineering;Tissues;transcriptomics;treatment comparison;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;tumorigenesis;United States;Vision;Work

PROJECT_TITLE: A microengineered colon cancer-chip designed to investigate tumor-stromal interactions driving cancer progression


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Organ Transplantation;Transplantation

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative HLA alloantigens represent a significant barrier to long term kidney transplant survival. Ultimately, we will attempt to develop a tool to help clinical professionals evaluate the expected outcomes from a given donor- recipient pair and titrating immunosuppression by identifying HLA amino acid mismatches that are likely to be particularly adverse or beneficial. This could provide a significant benefit for patients whose clinicians use this tool.

PI_NAMEs: KAMOUN, MALEK  (contact)

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Accounting;Acute;Address;Alloantigen;Allografting;Amino Acid Motifs;Amino Acids;Antibodies;Antibody Specificity;Antigens;Applications Grants;Binding;Categories;Clinical;Clinical Trials Design;clinically relevant;cohort;Complex;cost;Data;data imputation;data integration;Databases;Development;Dialysis procedure;donor-specific antibody;Drug toxicity;End stage renal failure;Engineering;ethnic diversity;Failure;Genes;Genetic Polymorphism;Genomic Segment;Goals;graft failure;Grouping;Hematopoietic Stem Cell Transplantation;Heterogeneity;high risk;Histocompatibility Antigens Class I;HLA Antigens;human leukocyte antigen testing;Immune;Immunogenetics;Immunosuppression;improved;Injury;Isoantibodies;kidney allograft;Kidney Transplantation;Linkage Disequilibrium;Machine Learning;Measures;Mediating;Modeling;Molecular;novel;organ allocation;Organ Donor;Organ Transplantation;Outcome;Patient risk;Patients;Peptides;Population;Positioning Attribute;post-transplant;premature;Proteins;Quality of life;Regimen;Resolution;Risk;risk stratification;Specificity;Statistical Data Interpretation;Surface;System;T-Lymphocyte;Testing;Titrations;tool;Transplant Recipients;transplant registry;Transplantation;Treatment Efficacy;Variant;Work

PROJECT_TITLE: HLA Immunogenetics and kidney allograft outcomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: DECLERCK, YVES A (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;California;Cancer Burden;Cancer Center Support Grant;cancer health disparity;career;career development;Catchment Area;central database;Clinical;clinical care;Clinical Sciences;Collaborations;college;Communities;Community Health;Community Health Education;Community Outreach;Complex;Comprehensive Cancer Center;continuing medical education;Coordination and Collaboration;Data Scientist;Databases;design;Direct Costs;Discipline;Ecosystem;Education;Educational Activities;elementary school;Engineering;Ensure;Evaluation;Evolution;Faculty;Feedback;Fostering;Funding;Goals;Graduate Education;graduate student;Grant;Health;Health Educators;health empowerment;Health Professional;Hispanic;Individual;innovation;Last Name;Leadership;Malignant Neoplasms;medical schools;member;Mentorship;Minority Groups;Mission;Modeling;multidisciplinary;Names;NCI Center for Cancer Research;next generation;Outcome;Peer Review;Peer Review Grants;Population;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Research;Research Personnel;Research Project Grants;Science;Scientist;Strategic Planning;success;Training;Training and Education;Translational Research;tumor microenvironment;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Electronic Nicotine Delivery Systems;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Liver Cancer;Liver Disease;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Tobacco;Urologic Diseases;Women's Health Research

PI_NAMEs: SETIAWAN, VERONICA WENDY (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adult;Affinity;African American population;Air Pollution;anti-cancer research;Big Data;Bioinformatics;Biological;Biological Markers;Biology;Biometry;Breast Cancer Risk Factor;California;Cancer Burden;Cancer Center Support Grant;Cancer Control Research Program;cancer epidemiology;Cancer Etiology;cancer genetics;cancer health disparity;cancer prevention;cancer risk;carcinogenicity;career;Caring;Catchment Area;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Colorectal Cancer;Community Health Education;Community Outreach;Complex;Comprehensive Cancer Center;Cytomegalovirus;Data;data integration;Data Linkages;Data Science;Development;Diabetes Mellitus;Disparity;Doctor of Philosophy;Education and Outreach;Educational Activities;Electronic cigarette;electronic cigarette user;Endometrial Carcinoma;Environmental Epidemiology;Environmental Risk Factor;epidemiologic discoveries;Epidemiologist;Epidemiology;epidemiology study;epigenomics;ethnic disparity;ethnic diversity;Ethnic Population;Etiology;Evaluation;Evolution;Exposure to;Faculty;Fostering;Funding;Genetic;Genetic Determinism;genetic epidemiology;Genetic Risk;genetic risk factor;Genomics;Goals;Grant;health equity;Incidence;Individual;Institution;Knowledge;Last Name;Latino Population;Lead;Life Style;lifestyle factors;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;meetings;member;Mentors;Mentorship;Methods;Minority Groups;Mission;Molecular;Molecular Epidemiology;Molecular Profiling;mortality;multi-ethnic;multidimensional data;Multiple Myeloma;Names;non-alcoholic fatty liver disease;novel;Obesity;Outcome;Paper;Pathology;Pathway interactions;Peer Review;polygenic risk score;Population Heterogeneity;Population Research;Population Study;Positioning Attribute;Prevalence;programs;prostate cancer risk;Publishing;Race;racial disparity;racial diversity;racial population;recruit;Regulation;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Behaviors;Risk Factors;risk stratification;Role;Science;Statistical Data Interpretation;Strategic Planning;Surveillance Program;survivorship;Technology;Tobacco;Training and Education;Translating;Translational Research;tumor microenvironment;tumor progression;Twin Multiple Birth;United States;Universities;University of Southern California Norris Cancer Center;vaping

PROJECT_TITLE: Cancer Epidemiology


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Childhood Obesity;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Pediatric;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Skin Cancer;Social Determinants of Health;Telehealth;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: COCKBURN, MYLES G (contact)

PROJECT_TERMS: Acceleration;Achievement;Acute Lymphocytic Leukemia;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adopted;Adoption;Adult;anti-cancer research;Behavior;behavior change;Behavior Therapy;Breast Cancer Genetics;California;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Control Research Program;cancer epidemiology;cancer health disparity;Cancer Patient;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;Career Mobility;Caring;Catchment Area;Center Core Grants;Cervical Cancer Screening;Clinical Sciences;cohort;Collaborations;Colorectal Cancer;combustible tobacco;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Data Science Core;Direct Costs;Disparity;Disparity population;Doctor of Philosophy;Ecological momentary assessment;Electronic cigarette;electronic cigarette use;Environmental Risk Factor;ethnic disparity;Ethnic Origin;Evaluation;Faculty;financial toxicity;Flavoring;follow-up;Fostering;Funding;genetic testing;Goals;Grant;Grant Review;Health behavior;Health Benefit;health disparity;health equity;Health Services Accessibility;Hispanic Populations;Human Papilloma Virus Vaccination;implementation science;improved;individualized prevention;innovation;Institution;Intervention;Investigation;Last Name;Lead;Leadership;Link;Los Angeles;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;Media Intervention;member;Mentors;mhealth interventions;multi-ethnic;multilevel analysis;Names;Obesity;obesity risk;obesity treatment;Outcome;Peer Review;Physical activity;Policies;Population Research;Poverty;Prevention program;preventive intervention;programs;protective factors;Publishing;Race;Research Personnel;Resource Sharing;Risk Behaviors;Risk Factors;school district;Schools;Science;Screening for cancer;Screening for Skin Cancer;Services;skin cancer prevention;social media;Strategic Planning;Sun Exposure;Surveillance Program;Technology;Teenagers;telehealth;Tobacco;tobacco products;Tobacco use;Training;Training and Education;Translating;Translational Research;tumor;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center;vaping;Woman;Work;Youth

PROJECT_TITLE: Cancer Control Research


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: LENZ, HEINZ JOSEF  (contact)

PROJECT_TERMS: Address;Adjuvant Therapy;Adult;Affinity;African American;anti-cancer research;Area;ARID1A gene;artemis;Award;Basic Science;Biological Assay;Biological Markers;Biological Response Modifier Therapy;California;cancer biomarkers;Cancer Burden;Cancer Center Support Grant;Cancer Control Research Program;cancer diagnosis;cancer epidemiology;cancer genome;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;candidate validation;Catchment Area;cell free DNA;Chest;circulating biomarkers;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;Combined Modality Therapy;community engagement;Community Outreach;Companions;Comprehensive Cancer Center;County;Data;design;Development;diagnostic biomarker;diagnostic strategy;dietary restriction;Disease;Disparity;Disseminated Malignant Neoplasm;DNA Methylation;Doctor of Philosophy;drug development;Drug Targeting;Dysmyelopoietic Syndromes;Early Diagnosis;Enrollment;Epigenetic Process;epigenomics;Evolution;Ewings sarcoma;faculty mentor;Fostering;Funding;gastrointestinal;Genitourinary system;genome sciences;genomic profiling;Genomics;Gills;Grant;GRP78 gene;health equity;Hematologic Neoplasms;Hematology;Immune checkpoint inhibitor;Immunologics;Immunotherapy;improved;in vivo;inhibitor;innovation;Institution;Intervention Trial;Investigational Therapies;investigator-initiated trial;Journals;Last Name;Lead;Leadership;leukemia;liquid biopsy;Liver diseases;Los Angeles;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;men;metastatic colorectal;Methods;Minority;Mission;Molecular;Molecular Profiling;Monitor;multidisciplinary;Mutation;Names;National Clinical Trials Network;NCI Center for Cancer Research;new therapeutic target;novel;novel marker;novel therapeutic intervention;Outcome;Paper;Patients;Peer Review;Pharmacodynamics;Phase;Pre-Clinical Model;preclinical efficacy;Predictive Cancer Model;predictive marker;Process;Prognostic Marker;programs;prostate cancer model;Publishing;Regulation;repository;Research;Research Project Grants;Resource Sharing;RNA;Science;Signal Transduction;Solid;Strategic Planning;therapeutic biomarker;therapeutic candidate;Therapeutic Intervention;therapeutic target;Tissues;translational progress;Translational Research;treatment response;tumor;tumor microenvironment;Underrepresented Minority;Universities;University of Southern California Norris Cancer Center;Validation;Woman;Work

PROJECT_TITLE: Translational and Clinical Sciences


NIH_SPENDING_CATS: Cancer;Genetics;Nutrition;Obesity;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Endometrial cancer incidence is increasing 1.3% year over year in the United States as a consequence of the obesity pandemic. A major gap in knowledge is how genetic mutations alter endometrial cancer risk in obese women, and evidence points towards impaired protein quality control as an important causal mechanism. This proposal addresses the goals of the NCI Strategic Plan to identify and characterize risk factors for cancer, to study how cellular stress responses contribute to cancer development and progression and to develop and test new approaches for cancer prevention through studies that will determine if recurrent phosphoinositide 3-kinase (PI3K) pathway mutations reshape protein quality control mechanisms in obese women at-risk for endometrial cancer.

PI_NAMEs: WILSON, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Address;American Cancer Society;anti-cancer research;Aromatase;Automobile Driving;Award;Bioinformatics;biological adaptation to stress;Body Weight;cancer cell;Cancer Patient;cancer prevention;cancer risk;career;career development;Cell Death;Cell Death Induction;Cell Survival;Cells;Cellular Stress;Data;Development;Disease;DNA Sequence Alteration;driver mutation;Endometrial;endometrial cancer prevention;Endometrial Carcinoma;Endometrium;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Epithelium;Estrogens;expectation;experience;Faculty;Genetic;Genetically Engineered Mouse;genomic profiling;Goals;graduate school;Growth;Gynecologic Oncology;High Risk Woman;Home;Homeostasis;Impairment;improved;Incidence;insight;Institution;Invaded;Knowledge;Lead;Location;Malignant Neoplasms;Mentors;Metabolic;Metabolism;Michigan;mouse model;mutant;Mutation;Myometrial;Normal Cell;novel;novel strategies;Nucleotide Biosynthesis;nutrition;obese person;Obesity;pandemic disease;Pathogenesis;Pathway interactions;Phenotype;Phosphatidylinositols;Phosphotransferases;Play;Positioning Attribute;Postdoctoral Fellow;Pregnancy loss;prevent;preventive intervention;Preventive measure;Preventive treatment;programs;protein folding;Proteins;proteostasis;Quality Control;Recurrence;Research;Research Institute;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;Sampling;Secure;Shapes;Signal Transduction;Somatic Mutation;Strategic Planning;Stress;Techniques;tenure track;Testing;Therapeutic;therapeutic target;Time;Training;Training and Education;transcription factor;tumor;tumor metabolism;tumorigenesis;uncontrolled cell growth;United States;Universities;Uterus;Woman;Women's mortality;XBP1 gene

PROJECT_TITLE: Does obesity influence protein quality control in endometrial cancer?

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

PI_NAMEs: DOU, YALI  (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Acute Lymphocytic Leukemia;Address;Affinity;Animal Model;anti-cancer research;Anti-viral Response;Antibodies;antitumor effect;Basic Science;Behavior;Binding Sites;biodemography;bioinformatics pipeline;Biological Markers;Biological Models;Blocking Antibodies;California;Cancer Biology;cancer biomarkers;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control Research;Cancer Detection;cancer epidemiology;cancer type;Catchment Area;Cell Death Induction;cell growth regulation;Cell surface;Cell Survival;Childhood;Chromatin;circadian regulation;Clinic;Clinical Sciences;Clinical Trials;Collaborations;Colon Carcinoma;Colorectal Cancer;community engagement;Community Outreach;Comprehensive Cancer Center;Cytoplasm;Data Science;Direct Costs;Disease;Disparity;DNA biosynthesis;DNA Methylation;Doctor of Philosophy;drug development;Education and Outreach;Epigenetic Process;epigenome;epigenomics;Evolution;Fostering;Funding;Gene Expression;Genes;Genetic Enhancer Element;Genetic Recombination;Genome;genome integrity;Genome Stability;Genomics;Glucocorticoids;Goals;Grant;Growth;GRP78 gene;health equity;hormonal signals;Immunologic Monitoring;Immunotherapy;In Vitro;inhibitor;Investigation;kinase inhibitor;Last Name;Lead;Leadership;leukemia;Link;Location;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Methods;Molecular;Molecular Chaperones;Monitor;mouse model;multimodality;Names;Neoplasm Metastasis;Normal Cell;novel;overexpression;Pathology;Pathway interactions;patient response;Peer Review;Phenotype;Phosphotransferases;population health;pre-clinical;predictive marker;Process;Prognosis;programs;Protamine Kinase;Publications;Publishing;recruit;Regulation;Relapse;Research;research and development;Resistance;Resource Sharing;response biomarker;Role;Science;Signal Pathway;Signal Transduction;small molecule;steroid hormone;steroid hormone analog;Strategic Planning;Therapeutic Agents;therapeutic biomarker;therapeutic target;Training and Education;Training Programs;transcription factor;Transcriptional Regulation;transcriptomics;Translating;translational genomics;Translational Regulation;Translational Research;Translations;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Universities;University of Southern California Norris Cancer Center;Viral Genes;Work;working group

PROJECT_TITLE: Genomic and Epigenomic Regulation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: KAST, WIJBE MARTIN (contact)

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Affinity;angiogenesis;anti-cancer research;Antibodies;Antigens;antitumor effect;Area;Asian population;B-Cell Lymphomas;Basic Science;Biological Assay;Biological Models;Biological Products;Body Weight;California;Cancer Burden;cancer cell;Cancer Center Support Grant;Cancer Control Research;Cancer Control Research Program;cancer education;cancer epidemiology;cancer health disparity;cancer immunotherapy;cancer therapy;Catchment Area;Cell Communication;cell stroma;Cell Therapy;Cells;Cellular Metabolic Process;cervical cancer prevention;Child;Childhood Acute Lymphocytic Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical investigation;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;Colorectal Cancer;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;Computer Models;County;Cyclic GMP;design;Development;Direct Costs;Disparity;Doctor of Philosophy;Effector Cell;elementary school;ENG gene;Ensure;Epigenetic Process;Etiology;Faculty;faculty mentor;FDA approved;Fostering;Funding;Funding Mechanisms;Grant;Hepatitis C virus;Hepatology;Hispanic Women;Human;Human Herpesvirus 8;Human Papillomavirus;Immune;Immune signaling;Immunooncology;Immunosuppression;Immunotherapy;Inflammation;Institution;interest;investigator-initiated trial;Journals;Langerhans cell;Last Name;Liver diseases;Liver neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;meetings;member;minority trainee;Mission;Modeling;Names;nano;Natural Killer Cells;Nature;NCI Center for Cancer Research;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;non-alcoholic fatty liver disease;novel;novel strategies;Oncology;Paper;Pathogenesis;Pathogenicity;Pathway interactions;Peer Review;Pilot Projects;Population;programs;Publishing;receptor expression;recruit;Research;Research Personnel;Resistance;Risk Factors;Role;Schools;Science;stem-like cell;Strategic Planning;Students;Systems Biology;T-Cell Receptor;T-Lymphocyte;targeted treatment;technology platform;Therapeutic Intervention;three-dimensional modeling;tool;Toxic effect;Training and Education;Translating;Translational Research;tumor;Tumor Biology;Tumor Escape;tumor immunology;tumor initiation;tumor microenvironment;Underrepresented Minority;Universities;University of Southern California Norris Cancer Center;Vesicle;Viral;virology;Virus;virus related cancer;Woman;Work

PROJECT_TITLE: Tumor Microenvironment


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cervical Cancer;Colorectal Cancer;Digestive Diseases;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: BAEZCONDE-GARBANATI, LOURDES A. (contact)

PROJECT_TERMS: Achievement;Acute Lymphocytic Leukemia;Address;Advocacy;African American;African American population;Age;American Indian Tribe;Amerindian;Appearance;Area;Asian;Asian population;Award;behavior change;bilingualism;California;Cancer Burden;Cancer Center Support Grant;cancer health disparity;Cancer Patient;Caring;Catchment Area;Center Core Grants;cervical cancer prevention;Cigarette;Cities;Clinical Trials;colon cancer patients;Colorectal Cancer;combustible cigarette;Communities;community advisory board;community engagement;Community Health;community organizations;Community Outreach;Comprehensive Cancer Center;County;Data;Death Rate;Disease;Disparity;Doctor of Philosophy;Education;Educational Materials;Electronic cigarette;Enrollment;Event;Exhibits;financial toxicity;Fostering;Foundations;Funding;Genomics;Government;Grant;health equity;Hispanic;Hispanic Populations;Home;Human Papilloma Virus Vaccination;Human Papillomavirus;Incidence;Individual;Language;Last Name;Leadership;life span;Los Angeles;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;member;men;Mission;Monitor;Monograph;mortality;Names;NCI Center for Cancer Research;Needs Assessment;Not Hispanic or Latino;Obesity;outreach;participant enrollment;patient navigation;patient oriented;Patient-Centered Care;Patients;Peer Review Grants;Persons;Policies;Population;Population Research;programs;Public Policy;recruit;Research;Resource Sharing;Risk;Scanning;Science;Screening for cancer;sedentary lifestyle;Services;Smoke;social media;South America;Spanish;Strategic Planning;Surveillance Program;Television;Therapeutic;Tobacco;tobacco control;Tobacco use;Tribes;Underrepresented Minority;United States;Universities;University of Southern California Norris Cancer Center;vaping

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;Achievement;Acute Lymphocytic Leukemia;Address;Advisory Committees;anti-cancer research;Applications Grants;Area;Asian population;Benchmarking;biobank;Bioinformatics;Biological Markers;California;Cancer Burden;cancer care;Cancer Center Support Grant;cancer genomics;cancer health disparity;cancer prevention;Cancer Science;Catchment Area;Cell Line;Cervical Cancer Screening;Clinical Trials;cohesion;Collaborations;Colorectal Cancer;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;County;COVID-19;COVID-19 pandemic;Cyclic GMP;Data Science;Decision Making;Development;Direct Costs;Disparity;Doctor of Philosophy;Education;Education and Outreach;Ensure;Epidemiology;ethnic disparity;ethnic diversity;Evaluation;Feedback;Fostering;Funding;Genome;genomic platform;Genomics;Goals;Grant;Growth;Height;Hispanic Populations;Human Papillomavirus;Immunotherapy;improved;Incidence;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Intervention Trial;Investments;Last Name;Lead;Leadership;Los Angeles;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;member;Minority Enrollment;Mission;Modeling;Molecular;Monitor;mortality disparity;mouse model;multidisciplinary;Names;NCI Center for Cancer Research;novel;Obesity;patient oriented;Patients;Peer Review;Population Research;Process;programs;Protocols documentation;racial disparity;racial diversity;recruit;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Rest;Risk Factors;Role;SARS-CoV-2 transmission;Schools;Science;Scientist;Services;Strategic Planning;Talents;Testing;Therapeutic Clinical Trial;therapeutic target;Tobacco use;Training;Training and Education;Universities;University of Southern California Norris Cancer Center;Vertebral column;Virus Diseases;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Address;Administrator;anti-cancer research;Area;Award;Basic Science;Bioinformatics;Biology;biomarker development;Biostatistics Core;Breast;California;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer research center director;Cancer Science;Catchment Area;Cervical Cancer Screening;Clinical;Clinical Research;Colorectal;Communities;Comprehensive Cancer Center;Coupled;Data Science;Decision Making;Development;Direct Costs;Disparity;Doctor of Philosophy;drug development;epigenomics;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Future;Genomics;Grant;health equity;Human Papillomavirus;Immunooncology;improved;innovation;Institution;interdisciplinary collaboration;Intervention;Investments;Last Name;Lung;Malignant Neoplasms;Medicine;member;Molecular;Names;NCI Center for Cancer Research;Obesity;Pediatric Oncology;Peer Review;Pilot Projects;population based;Population Research;Process;programs;Prostate;Records;recruit;Research;research and development;Research Institute;Resource Sharing;Resources;Review Committee;Risk Factors;Science;Seasons;Services;Shapes;Societies;Strategic Planning;success;therapeutic development;Tobacco;translational genomics;Translational Research;Universities;University of Southern California Norris Cancer Center

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Data Science

PI_NAMEs: WIEMELS, JOSEPH LEO (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Applications Grants;Basic Science;Biological Markers;Biology;Biostatistics Shared Resource;Budgets;California;Cancer Center Support Grant;cancer health disparity;cancer immunotherapy;cancer risk;Cancer Science;Catchment Area;Categories;Cell Therapy;Clinical Cancer Center;Clinical Sciences;Comprehensive Cancer Center;Core Biopsy;cost effective;Cyclic GMP;Data;Data Science;Data Science Core;design;Development;Disparity;Doctor of Philosophy;early phase clinical trial;Ensure;Equipment;Evaluation;Evolution;falls;Fees;Flow Cytometry;Fostering;Funding;Future;genome sciences;Genomics;Grant;Growth;high risk population;Immunologic Monitoring;improved;Individual;individualized prevention;innovation;Institution;Intervention Studies;Investments;Laboratories;Last Name;Lead;Leadership;liquid biopsy;Machine Learning;Maps;medical schools;meeting reports;meetings;member;Mission;Molecular;multidisciplinary;multimodality;Names;NCI Center for Cancer Research;novel;Pathology;Pathway interactions;Patients;Peer Review;Population;Population Research;Population Sciences;Positioning Attribute;pre-clinical;Process;programs;Publications;Recommendation;Reporting;Research;Resource Sharing;response;Risk Assessment;satisfaction;Schedule;Science;Scientist;Services;Shapes;Societies;Strategic Planning;Structure;Surveys;Technology;Translational Research;Universities;University of Southern California Norris Cancer Center;Update;Writing

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: EL-KHOUEIRY, ANTHONY BOUTROS (contact)

PROJECT_TERMS: Administrator;Asian;Black race;California;Cancer Center Support Grant;cancer clinical trial;Case Report Form;Catchment Area;Clinical;Clinical Cancer Center;Clinical Data;clinical investigation;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;COVID-19 pandemic;Data;data management;Data Science;Databases;design;Development;Disease;Education and Outreach;education planning;Eligibility Determination;Employee;Ensure;Environment;Evaluation;Faculty;financial toxicity;Generations;Grant;improved;Institution;Intervention Trial;investigator-initiated trial;Last Name;Leadership;life span;Malignant Neoplasms;Medidata;meetings;member;Minority;Minority Groups;minority patient;Mission;Monitor;multidisciplinary;Names;Operations Research;Participant;Patients;Phase;Physician Executives;Procedures;Process;programs;protocol development;Protocols documentation;quality assurance;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Role;Safety;service coordination;Services;Site;skills;Standardization;Supervision;System;therapy development;Time;tool;Training;Underrepresented Populations;Universities;University of Southern California Norris Cancer Center;Update;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: IQBAL, SYMA  (contact)

PROJECT_TERMS: California;Cancer Center Support Grant;Catchment Area;clinical investigation;Clinical Protocols;Clinical Sciences;Clinical Trials;cohort;Committee Members;Comprehensive Cancer Center;Consultations;design;Development;Disease;Documentation;early phase trial;Ensure;Evaluation;Faculty;flexibility;Future;Grant;improved;Institution;Institutional Review Boards;Intervention Studies;Intervention Trial;investigator-initiated trial;Last Name;Leadership;life span;Malignant Neoplasms;Medial;meetings;member;Mentorship;Minority;minority patient;Minority Recruitment;molecular subtypes;Monitor;multidisciplinary;Names;NCI Center for Cancer Research;Patients;Peer Review;phase 1 study;Policies;Process;process improvement;programs;Protocols documentation;rare cancer;Research Design;Review Committee;Speed;Standardization;System;Systems Development;Time;timeline;Training;Translational Research;Universities;University of Southern California Norris Cancer Center;Update;Woman;women patients;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


PROJECT_TERMS: anti-cancer research;Antibodies;Basic Cancer Research;Basic Science;Biological Markers;Breast;Breast Cancer Model;Breast Melanoma;Budgets;California;cancer cell;Cancer Center Support Grant;cancer clinical trial;cancer immunotherapy;Cancer Patient;cancer prevention;Cancer Vaccines;CD8B1 gene;Cell Separation;Cell surface;Cell Therapy;Cells;Charge;chemoradiation;chemotherapy;Chromatin Loop;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Cooperative Group;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;Comprehensive Cancer Center;Consultations;Copy Number Polymorphism;Correlative Study;cost;cost effective;Cytometry;cytotoxic;Data;Diagnostic;Diet;Direct Costs;Disease Outcome;Doctor of Philosophy;Education;ENG gene;epigenomics;Equipment;Faculty;Fasting;Feedback;Flow Cytometry;Fluorescence;Foundations;Funding;Genome;Genomics;Genomics Shared Resource;Grant;Gynecologic Oncology Group;high throughput analysis;Immune;Immune checkpoint inhibitor;immune function;Immunologic Monitoring;immunological status;Immunologics;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;Institution;instrument;ipilimumab;Laboratories;Last Name;Local Therapy;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;member;mesenchymal stromal cell;Methods;Mission;Molecular;mutant;Names;Natural Killer Cells;Neoplasm Circulating Cells;Neuroblastoma;Oncology;Pathogenesis;Pathology;Patients;Peer Review;Phenotype;Population;pre-clinical;programs;prostate cancer risk;Proteins;Publications;Regulation;Reporting;Research;Research Design;Research Personnel;Research Support;Resolution;Resource Sharing;response;Role;satisfaction;Services;Sorting;Surveys;System;T cell clonality;Technology;Therapeutic;Training and Education;transcriptome sequencing;translational cancer research;Translational Research;Tropism;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Universities;University of Southern California Norris Cancer Center;vector

PROJECT_TITLE: Flow Cytometry Core


PI_NAMEs: CRAIG, DAVID W (contact)

PROJECT_TERMS: Adjuvant Therapy;African American;African American Women;anti-cancer research;arm;Basic Science;Bioinformatics;Biological Assay;Biology;biomedical informatics;Breast Cancer therapy;Budgets;California;cancer cell;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer genome;cancer genomics;cancer health disparity;Catchment Area;Cells;Charge;CLIA certified;Clinical;Clinical Research;Clinical Sciences;Collaborations;Comprehensive Cancer Center;computerized data processing;Consult;Cytometry;Data;Data Science;Data Science Core;design;Development;Direct Costs;Disseminated Malignant Neoplasm;DNA copy number;DNA Methylation;Doctor of Philosophy;Elements;Emerging Technologies;Ensure;epidemiology study;Epigenetic Process;epigenomics;exome sequencing;Faculty;Fostering;Funding;Gene Expression;Generations;Genetic;genomic profiling;Genomics;Genomics Shared Resource;Grant;Heterogeneity;High-Throughput Nucleotide Sequencing;Image;industry partner;Industry Standard;informatics tool;Infrastructure;Institution;investigator training;Laboratories;large scale production;Last Name;Leadership;liquid biopsy;Los Angeles;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;men;Methodology;Methods;Methylation;Mission;Molecular;Molecular Profiling;multiple omics;Names;nano-string;National Cancer Institute;NCI Center for Cancer Research;patient population;Patients;Pediatric Hospitals;Pituitary Gland Adenoma;Population Sciences;Predisposition;Process;programs;Publications;recruit;Regulation;Reporting;Research;Research Design;Research Personnel;research study;Residual Neoplasm;Resource Sharing;Robotics;screening;Services;single cell genomics;SNP genotyping;Strategic Planning;symposium;Technology;Training;transcriptome sequencing;transcriptomics;translational genomics;Translational Research;tumor;tumor microenvironment;Universities;University of Southern California Norris Cancer Center;Variant;Woman;Work

PROJECT_TITLE: Molecular Genomics Core


PI_NAMEs: GOLDKORN, AMIR  (contact)

PROJECT_TERMS: Academia;Address;American Association of Cancer Research;American Society of Clinical Oncology;anti-cancer research;Atlases;Award;Biological Assay;Biological Markers;Blood;Blood specimen;Budgets;California;Cancer Center Support Grant;Cancer Detection;Cell Count;cell free DNA;Cell Separation;Cells;Charge;Clinical;Clinical Sciences;Collaborations;commercialization;Communities;Comprehensive Cancer Center;Core Biopsy;cost effective;Development;Direct Costs;Disease Management;DNA amplification;DNA Library;DNA methylation profiling;Emerging Technologies;empowerment;epigenomics;Expression Profiling;Extramural Activities;Extramural Funding Mechanisms;Faculty;Foundations;Funding;Gene Dosage;Generations;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;hormone therapy;Hour;Immune checkpoint inhibitor;Immunofluorescence Immunologic;improved;Industry;industry partner;insight;Institution;Institutional Review Boards;instrument;International;Last Name;liquid biopsy;Malignant Breast Neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;member;men;Methodology;Methods;Methylation;Microfluidics;Microscopy;Mission;Molecular;multiple omics;Mutation;Names;Neoplasm Circulating Cells;new technology;new therapeutic target;novel;Nucleic Acids;Occupational activity of managing finances;operation;Oral;Paper;Patients;Peer Review;Phase;Phenotype;Plasma;Plasma Cells;precision medicine;predictive signature;Primary carcinoma of the liver cells;Process;Prognosis;prognostic;programs;prospective;Prostate Cancer therapy;Protocols documentation;Publishing;radiomics;Recovery;Regulation;Research;research and development;Research Personnel;Resource Sharing;response;RNA;RNA amplification;Role;sample collection;Seminal;Services;Slide;Southwest Oncology Group;Strategic Planning;System;TACSTD1 gene;Technology;therapeutic biomarker;Time;timeline;transcriptome sequencing;transcriptomic profiling;Translational Research;translational research program;tumor;tumor DNA;tumor microenvironment;Universities;University of Southern California Norris Cancer Center;Update;user-friendly;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Liquid Biopsy Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: WALLACE, WILLIAM DEAN (contact)

PROJECT_TERMS: Achievement;Adhesions;Adult;African American;African American population;Anatomy;anti-cancer research;Antibodies;Attention;B-Cell Acute Lymphoblastic Leukemia;Basic Science;bioinformatics tool;Biological Markers;Biopsy;Blood;Blood specimen;Bone Marrow;Budgets;California;Cancer Center Support Grant;cancer epidemiology;cancer health disparity;Cancer Patient;Caring;Case/Control Studies;Catchment Area;Cells;Characteristics;Charge;Childhood;CLIA certified;Clinical Cancer Center;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Colon Carcinoma;Comprehensive Cancer Center;Consent;cost effective;Custom;Data Science Core;database query;design;Development;Diagnostic;Direct Costs;DNA Methylation;Doctor of Philosophy;Early Therapeutic-Clinical Trials Network;Enrollment;Ensure;Epidemiology;epidemiology study;epigenomics;ethnic diversity;Excision;Formalin;Fostering;Freezing;Fresh Tissue;Funding;Future;gang;Gene Expression;Genets;genome sequencing;Genomics;Germ Lines;Grant;health equity;Hispanic Populations;Hospitals;Human;human tissue;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;Institution;Integrin alpha6;Investigational Therapies;Last Name;leukemia;Link;Los Angeles;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mission;Molecular;Mononuclear;multi-ethnic;Mutation;Names;National Clinical Trials Network;NCI Center for Cancer Research;Neoplasm Metastasis;Nephroblastoma;Neuroblastoma;Normal tissue morphology;novel marker;novel therapeutics;operation;Paraffin Embedding;Participant;participant enrollment;Pathology;pathology imaging;Pathway interactions;patient population;Patients;Pediatric Hospitals;peripheral blood;population based;Population Study;Process;programs;promoter;Publications;racial diversity;Registries;Regulation;repository;Research;Research Personnel;research study;Research Support;Residual state;Resource Sharing;Resources;Risk Factors;Sampling;Sarcoma;Scanning;Services;Specimen;Strategic Planning;Surveillance Program;therapeutic target;Time;Tissue Banks;Tissue Embedding;Tissue Microarray;Tissue Model;tissue processing;Tissue Procurements;Tissues;transcriptome sequencing;translational goal;Translational Research;translational study;tumor;tumor microenvironment;Tumor Tissue;Universities;University of Southern California Norris Cancer Center;Validation;Whole Blood;whole genome;whole slide imaging;Work

PROJECT_TITLE: Translational Pathology Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neuroblastoma;Neurosciences;Ovarian Cancer;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: LI, MING  (contact)

PROJECT_TERMS: African ancestry;Algorithms;Animal Experimentation;Animal Model;anti-cancer research;Artificial Intelligence;Basic Science;Big Data;Bioinformatics;Biological Assay;Biometry;Biostatistical Methods;Biostatistics Shared Resource;Black Populations;Blood;Budgets;California;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer epidemiology;Cancer Etiology;cancer health disparity;Cells;Charge;Clinical;Clinical Research;Clinical Sciences;clinical trial protocol;Clinical Trials;Comprehensive Cancer Center;computerized data processing;Custom;Data;data acquisition;Data Analyses;data integration;data platform;data quality;Data Science;Data Science Core;Databases;design;Development;DNA;Doctor of Philosophy;electronic health information;Electronic Health Record;Elements;epigenomics;Evaluation;Evolution;Experimental Designs;Fostering;Funding;Gene Expression Profile;Genets;genome wide association study;Genomics;Germ Lines;Grant;Image;immune cell infiltrate;improved;Individual;Informatics;Infrastructure;inquiry-based learning;insight;Institution;Laboratory Study;Last Name;Latino Population;Leadership;liquid biopsy;Machine Learning;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Medidata;member;men;Methodology;Methods;Mission;Modeling;Monitor;monitoring device;Mosses;multi-ethnic;Multiomic Data;Mutation;Names;NCI Center for Cancer Research;Neuroblastoma;novel;novel strategies;Observational Study;Outcome;ovarian neoplasm;Patient Outcomes Assessments;Patients;Pediatric Oncology Group;Phenotype;Play;Population;Prognosis;programs;Protocols documentation;Publications;Quality Control;Questionnaires;recruit;Regulation;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Review Committee;Risk;Risk Factors;risk stratification;RNA;Role;Safety;Sampling;Serous;Services;Source;Specimen;Statistical Methods;Strategic Planning;Structure;System;Techniques;Tissues;tool;Training Activity;Training and Education;trait;Translational Research;tumor;tumor microenvironment;Tumor Tissue;Universities;University of Southern California Norris Cancer Center;wireless sensor;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Accelerometer;Acculturation;African American;African American population;Applications Grants;Area;Assessment tool;Behavioral;Budgets;California;Cancer Burden;Cancer Center Support Grant;Cancer Control Research;Cancer Control Research Program;cancer epidemiology;cancer health disparity;cancer risk;Catchment Area;Center Core Grants;Charge;Child;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Collection;Communities;Comprehensive Cancer Center;Consult;Consultations;Data;Data Collection;Data Element;data registry;data resource;Data Science Core;data standards;Development;Diabetes Mellitus;Direct Costs;Disparity;Doctor of Philosophy;dosimetry;early onset;Ecological momentary assessment;effectiveness evaluation;Ensure;Environmental Risk Factor;Epidemiology;Evaluation;feasibility research;Feedback;Funding;Grant;health determinants;Hispanic;Hispanic Populations;Hospitals;HPV vaccine hesitancy;Human Papilloma Virus Vaccination;improved;Incidence;Individual;Institution;Intervention;intervention effect;Last Name;Link;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical;Medicare;Melanoma;member;men;Mission;Monitor;Moods;mortality;Names;NCI Center for Cancer Research;Neighborhoods;neoplasm registry;novel;novel strategies;nutrition;Obesity;obesity prevention;operation;Outcomes Research;Peer Review;Pesticides;Phase;Physical activity;population based;Population Heterogeneity;Population Research;Preparation;Process;programs;Publications;recruit;Research;Research Personnel;research study;Resource Sharing;response;Risk;Risk Factors;Role;Running;Science;secondary analysis;Services;smoking prevalence;sociodemographics;Strategic Planning;surveillance data;surveillance study;Surveys;survivorship;Technology;Tobacco;tobacco prevention;Tobacco-Related Carcinoma;tool;Training;Training Activity;Training and Education;Training Programs;Translational Research;trend;tumor microenvironment;Underserved Population;Universities;University of Southern California Norris Cancer Center

PROJECT_TITLE: Population Research Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing public health challenges, for which effective treatment is still lacking. At least two major themes have emerged from the studies of ALS/FTD, concerning etiology related to dysregulation of protein and RNA homeostasis. The work in this proposal is directed at understanding the novel functions of proteins, organelles, and pathways related to protein and RNA homeostasis especially under stress conditions, providing much needed insights into understanding specific forms of the neurodegenerative diseases as well as new strategies for developing therapeutic interventions.

PI_NAMEs: WANG, JIOU  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Animal Model;Arsenites;Biochemical;biological adaptation to stress;Biological Process;Brain;C9ORF72;Cell model;Cell Physiology;Cells;Cellular Stress;Collection;Cytoplasm;Cytoplasmic Granules;Development;Disease;DNA Maintenance;effective therapy;EIF-2alpha;Energy Metabolism;Etiology;FRAP1 gene;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic;genetic approach;Goals;Health;Homeostasis;human disease;Immune response;Immune signaling;in vivo;induced pluripotent stem cell;Inflammation;insight;Intervention;Link;Liquid substance;Membrane;Messenger RNA;Modeling;Molecular;Motor Neurons;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;novel;Organelles;Organoids;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phase;Phosphorylation;Physiological;Play;Process;programs;protein aggregation;Protein Biosynthesis;protein complex;protein function;protein misfolding;Proteins;Public Health;Research;response;Ribonucleoproteins;RNA;RNA-Binding Proteins;Role;Series;Signal Transduction;Stimulator of Interferon Genes;Stress;stress granule;Structure;Therapeutic Intervention;Translational Regulation;Translations;Work

PROJECT_TITLE: Investigating Dysregulation of Stress-related Ribonucleoprotein Granules and Functions of Associated RNA-binding Proteins in ALS/FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE CDK4/6 inhibitors in combination with endocrine therapy are currently considered standard of care for patients with advanced estrogen receptor positive breast cancer but, virtually all patients will eventually acquire clinical resistance to CDK4/6 inhibitor therapy. We have discovered a novel mechanism of resistance, which is mediated by high levels of IL-6 and activation of STAT3, targetable by an orally available small molecule inhibitor (TTI- 101). The proposed translational studies will be testing the efficacy of TTI-101 clinically to treat those patients who are likely to be unresponsive to CDK4/6 inhibitors.

PI_NAMEs: KEYOMARSI, KHANDAN  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Ablation;Address;Adjuvant;adjuvant endocrine therapy;advanced breast cancer;Affect;Aromatase Inhibitors;autocrine;Binding;Biological Markers;biomarker identification;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;CDK4 gene;Cell Cycle;Cell Line;Cell secretion;Cell Survival;Cells;checkpoint therapy;chemotherapy;Clinical;cytokine;Disease;Dose;Down-Regulation;Early treatment;efficacy testing;Endocrine;Enrollment;epithelial to mesenchymal transition;ERBB2 gene;Estrogen receptor positive;estrophilin;Evaluable Disease;experience;Gene Expression Profile;Genetic;Genomics;Goals;Growth;Growth Factor;high-throughput drug screening;Homodimerization;hormone therapy;IL-6 inhibitor;Immune checkpoint inhibitor;improved;in vivo;Inflammatory;inhibitor;inhibitor therapy;Interleukin-6;Interleukins;Knockout Mice;Malignant Breast Neoplasm;Mammospheres;MCF7 cell;Mediating;Modeling;Molecular Analysis;mortality;mouse model;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel therapeutic intervention;Operative Surgical Procedures;Oral;Organoids;paracrine;Pathway interactions;Patient Care;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;Phase Ib Trial;Phase Ib/II Clinical Trial;phase II trial;Phenotype;Phosphorylation;Population;pre-clinical;preclinical trial;predictive marker;Primary carcinoma of the liver cells;programs;Proteomics;Qualifying;Recurrence;research clinical testing;Resistance;Resistance development;resistance mechanism;response;Retinoblastoma Protein;Risk;Role;Safety;senescence;senescence associated secretory phenotype;senescent cell;Serious Adverse Event;Serum;small molecule inhibitor;Solid Neoplasm;src Homology Region 2 Domain;standard of care;STAT3 gene;stem;T47D;targeted treatment;Testing;Time;transcriptomics;Transgenic Mice;Transgenic Model;Transgenic Organisms;translational study;Treatment Protocols;treatment strategy;tumor;tumor growth;Tumor Promotion;Tumor Volume;tumor xenograft;tumor-immune system interactions;tumorigenesis;Tyrosine Phosphorylation;Up-Regulation;virtual

PROJECT_TITLE: Targeting STAT3 for the Treatment of CDK4/6 Inhibitor Resistant Advanced Estrogen Receptor Positive Breast Cancer Patients

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Lung cancer remains the most common source of cancer deaths annually in the United States and worldwide, and the tumor suppressor LKB1 is one of the most frequently mutated genes in this disease. We recently discovered that Histone Deacetylase 3 (HDAC3) is required for lung tumor growth in vivo, and we identified two specific mechanisms involved. This proposal aims to further investigate these mechanisms by 1) identifying the molecular explanations for LKB1 specific HDAC3 function, and 2) defining how HDAC3 represses the Senescence-Associated Secretory Phenotype (SASP) and immune cell recruitment.

PI_NAMEs: EICHNER, LILLIAN J. (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Acetylation;anti-cancer research;Area;Attention;Basal Cell;Binding;Biochemistry;Biological;Biology;cancer cell;career;Cell Aging;Cells;Cessation of life;Complex;Coupled;Disease;Doctor of Philosophy;experimental study;Faculty;Foundations;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Growth;HDAC3 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Immune;In Vitro;in vivo;inhibitor;insight;interest;Investigation;Link;Lung;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;MEKs;Molecular;mutant;Mutate;Mutation;mutational status;NCOR1 gene;neoplastic cell;NF-kappa B;Non-Small-Cell Lung Carcinoma;novel;Nuclear Receptors;Outcome Study;p65;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;Positioning Attribute;post-doctoral training;pre-clinical;programs;protein complex;recruit;Regulation;Repression;Research;Resistance;Role;senescence;senescence associated secretory phenotype;Signal Pathway;Signal Transduction;Source;Specificity;STK11 gene;targeted treatment;tenure track;Therapeutic;therapeutic evaluation;TP53 gene;transcription factor;treatment response;tumor;Tumor Biology;tumor growth;Tumor Promotion;Tumor Suppressor Proteins;Tumor-infiltrating immune cells;United States;Work

PROJECT_TITLE: The HDAC3 pathway in LKB1-mutant lung cancer and senescence


PHR: PROJECT NARRATIVE Considerable progress has been made in developing effective targeted therapies for NSCLC patients harboring typical EGFR mutations (L858R and exon 19 deletions), but no advancements had been made for NSCLC patients bearing atypical EGFR exon 20 insertion mutations who are inherently resistant to the same treatment regimens. For this population, we recently identified poziotinib as a potent and clinically active compound, but critical questions remain regarding mechanisms of resistance to this agent and other tyrosine kinase inhibitors (TKIs) targeting EGFR exon 20 insertions. This project addresses a critical, unmet need to define mechanisms of resistance in this patient population and to identify therapeutic strategies to overcome resistance.

PI_NAMEs: HEYMACH, JOHN V. (contact);WONG, KWOK KIN

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;aurora kinase A;Bypass;Cancer Patient;Cell Line;Clinical;Clinical Research;Clinical Trials;Collaborations;combat;Data;Development;DNA Sequence Alteration;Drug resistance;drug sensitivity;effective therapy;efficacy evaluation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Erlotinib;Evaluable Disease;Exons;experience;FDA approved;Future;Gefitinib;Generations;Genetically Engineered Mouse;Genomics;Goals;improved;in silico;In Vitro;in vivo;Induced Mutation;inhibitor;Insertion Mutation;Lead;Letters;Location;Malignant neoplasm of lung;Maps;Mediating;Medical Oncology;Medicine;Modeling;Molecular;molecular modeling;molecular pathology;mouse model;multidisciplinary;mutant;Mutation;Nature;Non-Small-Cell Lung Carcinoma;objective response rate;Outcome;partial response;Pathway interactions;patient population;Patients;Pattern;Pharmaceutical Preparations;phase II trial;Point Mutation;Population;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Productivity;Proteomics;Publications;Regimen;Reporting;Research Personnel;Resistance;resistance mechanism;resistance mutation;Resources;response;Retrospective Studies;Role;screening;Signal Pathway;Signal Transduction;Structure;Structure-Activity Relationship;Study models;targeted agent;targeted treatment;Testing;Therapeutic;Treatment Protocols;treatment strategy;tumor;Tyrosine Kinase Inhibitor;virtual

PROJECT_TITLE: Therapeutic strategies against EGFR exon 20 mutant lung cancer


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: The major reason for the lack of satisfactory management of melanoma is our poor understanding of the biology of melanoma development, progression and metastasis. Proposed studies on the role of IGF2BP1 in melanoma progression and metastasis are highly significant not only for the understanding the pathogenesis of malignant melanoma, but also for the validation of a novel target for the therapy and/or prevention of melanoma.

PI_NAMEs: SPIEGELMAN, VLADIMIR S. (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Affect;American Cancer Society;Bioinformatics;Biology;cell growth;Cell Survival;Cells;Cellular biology;Cessation of life;Clinical;Complementary DNA;Cytoplasm;Data;Databases;design;Development;Diagnosis;Dimensions;Disease-Free Survival;Down-Regulation;extracellular vesicles;Gene Expression;Genes;Genetic Transcription;Genetically Engineered Mouse;Half-Life;Human;Hypoxia;In Vitro;in vivo;in vivo evaluation;insight;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Messenger RNA;Metastatic Melanoma;Molecular Biology;mouse model;mRNA Expression;Neoplasm Metastasis;new therapeutic target;novel therapeutics;Outcome;overexpression;Pathogenesis;Pathway interactions;Play;Prevention;Primary Neoplasm;Proteins;Regulation;Resistance;RNA;RNA-Binding Proteins;Role;Serum;technology development;Testing;The Cancer Genome Atlas;Transcript;Transfer RNA;Translations;tumor progression;Untranslated RNA;uptake;Validation

PROJECT_TITLE: Role and mechanisms of IGF2BP1 in melanoma pathogenesis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: This project is designed to identify the molecular and cellular changes that occur in sensory neurons after axonal injury and establish how these drive neuropathic pain and the evolution of peripheral neuropathy, exploring the extent to which these two syndromes are distinct or linked, and identifying opportunities for new therapeutic intervention.

PI_NAMEs: WOOLF, CLIFFORD J (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Afferent Neurons;Animals;Axon;axon injury;axonal degeneration;Behavioral;Cells;chemotherapeutic agent;Chemotherapy-induced peripheral neuropathy;Clinical;design;Development;Disease;Disease susceptibility;Evolution;Exposure to;Fiber;Genetic;Genetic Transcription;Goals;Image;Individual;Ion Channel;Link;Malignant Neoplasms;Molecular;Mutation;Neurons;Neuropathy;neurotoxic;new therapeutic target;novel therapeutic intervention;novel therapeutics;Pain;painful neuropathy;Pathology;Patients;Peripheral;Peripheral Nervous System Diseases;Phenotype;Population;Resolution;response;Risk Factors;Sensory;side effect;Sodium Channel;stem;Syndrome;Time;voltage

PROJECT_TITLE: Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain