NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PHR: NARRATIVE The Harvard-wide Program on Antibiotic Resistance is designed to fill critical gaps in knowledge that will allow new approaches for treating serious infections with antibiotic resistant staphylococci and enterococci to be developed. The Administrative Core provides overall coordination and orchestration of this effort, and facilitates sharing results from this project with the scientific community to catalyze progress in addressing the global health crisis of antibiotic resistance. This is done by creating structures that enhance the synergistic interaction among a multidisciplinary team, and that insure the rigorous execution of the experimental plan in a manner that is fully transparent, accountable, and authenticated.

PROJECT_TERMS: Accountability;Address;Algorithms;Antibiotic Resistance;antibiotic resistant infections;Antibiotic susceptibility;Antibiotics;antimicrobial;Area;Boston;catalyst;Center for Translational Science Activities;Clinical Sciences;Collaborations;Communicable Diseases;Communication;Communities;conflict resolution;Coupled;Creativeness;data sharing;design;Development;Ear;Ensure;Enterococcus;Expenditure;experience;Eye;Fostering;General Hospitals;Genus staphylococcus;global health;Goals;Government;Hospitals;Human Resources;Individual;Industry;Infection;Infrastructure;innovation;insight;Institution;interdisciplinary approach;Knowledge;Lead;Leadership;Massachusetts;Mathematical Biology;medical schools;meetings;methicillin resistant Staphylococcus aureus;microbial;Molecular Biology;mortality;Multi-Drug Resistance;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;novel strategies;Participant;Pathway interactions;Performance;Predisposition;prevent;Privatization;programs;Public Health;Records;Reporting;Research;Research Personnel;Resistance;Resources;Science;Scientist;Structure;synergism;Systems Biology;Technology;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Oriented cell divisions represent a crucial mechanism to control cell fate choices, and in the skin epidermis, a progenitor’s division axis dictates whether it self-renews or differentiates. When orientation errors cause this balance to be perturbed, this results in altered cell fates, disrupted tissue architecture, and potentially cancer. In this proposal, we will determine how division orientation is influenced by both intrinsic factors such as polarity cues, and extrinsic factors such as the adhesive forces within the local microenvironment, and investigate how its dysregulation may contribute to the pathogenesis of congenital human skin diseases.

PI_NAMEs: WILLIAMS, SCOTT E (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Adherens Junction;Adhesions;Adhesives;afadin;alpha catenin;Anaphase;Apical;Architecture;Basal Cell;Behavior;Bulla;Cadherins;Carcinoma;cell cortex;Cell Density;Cell division;Cell Fate Control;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;cleft lip and palate;cohort;Communities;Complex;congenital skin disorder;Cues;Daughter;Defect;Development;Disease;Ectodermal Dysplasia;Embryo;Epidermis;Epidermolysis Bullosa;Epithelium;Equilibrium;ex vivo imaging;experimental study;flexibility;Focal Adhesions;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Models;Genetic Techniques;Goals;GPSM1 gene;GPSM2 gene;Growth;Hemidesmosomes;Homeostasis;Homologous Gene;Human;human disease;Hyperplasia;Image;in vivo;innovation;insight;Integrins;Intrinsic factor;Junctional Epidermolysis Bullosa;knock-down;Knowledge;Label;Learning;loss of function;Malignant Neoplasms;mechanotransduction;Mediating;Metaphase;Mitosis;Modality;Modeling;Molecular;Morphogenesis;mouse model;Mutate;Mutation;Nature;nectin;Online Mendelian Inheritance In Man;Outcome;paralogous gene;Pathogenesis;Pathologic;Pathway interactions;Pattern;Phenotype;Phosphorylation;Play;Positioning Attribute;Process;progenitor;Proliferating;Property;protein protein interaction;Proteins;Proteomics;real-time images;Resources;response;RNA Interference;Role;Scaffolding Protein;self-renewal;Shapes;Signal Pathway;Skin;skin disorder;skin organogenesis;stem;stem cell division;stem cell exhaustion;stem cells;Stratification;Stratified Epithelium;Stratum Basale;Structure;Syndrome;Techniques;telophase;therapy development;Time;tissue stress;Tissues;tool;treatment strategy;ultrasound;Variant;Vinculin;Work

PROJECT_TITLE: Intrinsic and extrinsic spindle orientation mechanisms in mammalian epidermis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: NARRATIVE The Mother Machine Technical Core provides access for each of the subprojects to leading-edge technology for continuous single cell imaging of populations of thousands to millions of bacteria per experiment. This capability, which cannot readily be replicated in other labs and is not commercially available, allows rare cells in an altered physiological state, such as those that persist despite the presence of otherwise lethal levels of antibiotics, to be examined for susceptibility to new antibiotics being designed in this P01. It also provides a deep, rich and precise description of every mutant in a large mixed population, such as mariner transposon insertions in a Tn-seq mutant pool, along with the ability to recover and further study mutants of interest, for studies identifying new antibiotic targets.

PI_NAMEs: PAULSSON, JOHAN  (contact)

PROJECT_TERMS: Ablation;Address;Algorithms;analysis pipeline;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Bacillus subtilis;Bacteria;Behavior;Cell division;cell growth;Cell Size;Cells;Cellular Assay;cellular imaging;Cellular Morphology;Chromosomes;Complex;Data;Data Analyses;data handling;data platform;Data Scientist;Dedications;Deoxyribonucleases;design;Devices;Dimensions;Engineering;Ensure;Enterococcus;Enterococcus faecalis;Environment;Environmental Risk Factor;Escherichia coli;experience;experimental study;feeding;Generations;Genes;Genetic;Genetic Screening;genetic variant;Genotype;Genus staphylococcus;global health;Growth;Health;Image;Individual;Infrastructure;innovation;interest;Investigation;Laboratories;Lasers;Libraries;Location;Mammalian Cell;Measurement;Measures;Methods;Microbial Biofilms;Microfluidics;Microscopy;Morphology;Mothers;mutant;Noise;optic trap;optical traps;Output;Phenotype;Physiologic pulse;Physiological;Population;Predisposition;programs;Property;Publishing;Reporter;Research;Research Project Grants;Resources;response;Retrieval;Running;Science;Series;Shapes;Staphylococcus aureus;statistics;Sum;Systems Analysis;Systems Biology;Technology;technology development;Time;tool;Translating;transposon sequencing;Variant;virtual;Visualization software;Work

PROJECT_TITLE: Technical Mother Machine Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE The goal of this research is to develop a fluoride-mediated desilylation (FMDS) 11C-labeling methodology, and use this novel approach for facilitating 11C-labeled radiotracer development to synthesize novel, currently radiochemically inaccessible or difficult to access PET agents.

PI_NAMEs: QU, WENCHAO  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acetic Acids;Address;Affinity;Aldehydes;Amides;Anions;Atmosphere;Basic Science;Biochemical;Biological;biological systems;Carbon;Carbon Dioxide;carboxylation;Carboxylic Acids;Cardiovascular system;Catalysis;chemical property;Chemicals;Chemistry;Clinical;clinical diagnostics;Clinical Research;Cyclotrons;Development;Disease;drug-like compound;Electrons;enzyme substrate;Esters;Event;Fatty Acids;Fluorides;functional group;Gases;Goals;Half-Life;image translation;Imaging Device;Imaging Techniques;In Situ;in vivo;interest;Intervention;Investigation;Label;Lead;Longitudinal Studies;Low Dose Radiation;Mediating;Metabolism;Metals;Methodology;Methods;Methylation;Modality;Molecular;molecular imaging;Neurologic;Nitrogen;novel;novel strategies;Nuclear;Oncology;Organism;Oxygen;Palmitic Acids;pharmacologic;Positioning Attribute;Positron;Positron-Emission Tomography;Production;Property;Pyruvic Acid;Radio;radiochemical;Radiochemistry;Radioisotopes;Radiolabeled;radiotracer;Reaction;Reagent;receptor binding;Reporting;Research;Research Personnel;Scanning;screening;Skeleton;Solvents;Source;Structure;Succinic Acids;Sulfonamides;Sulfur;Temperature;Thermodynamics;Tracer;Translating;Vorozole

PROJECT_TITLE: Fluoride-Mediated Desilylative Radiosynthesis of 11C-Labeled PET Tracers

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PHR: PROJECT NARRATIVE Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for significant morbidity and mortality worldwide. Project 1 seeks to capitalize on discoveries about S. aureus that were made through collaborating on innovative technological and conceptual approaches with other Project Team members. We will elucidate two S. aureus pathways that are targets for anti-infective compounds, and identify compounds and strategies that may allow us to exploit these pathways to treat MRSA infections.

PI_NAMEs: WALKER, SUZANNE  (contact)

PROJECT_TERMS: acyl group;Aftercare;Amino Acids;analog;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Physiology;beta-Lactams;Biochemical;Biogenesis;biological adaptation to stress;Biological Assay;cell envelope;Cellular Structures;Cessation of life;Chemistry;Collaborations;Communities;Complex;data mining;density;Down-Regulation;Enterococcus faecalis;Environment;Enzymes;ESKAPE pathogens;experimental study;Firmicutes;Foundations;Funding;Future;Genes;Genetic;Genomics;Glycolipids;Growth;Hospitals;Image Analysis;Individual;Infection;inhibitor;innovation;innovative technologies;insight;Integral Membrane Protein;Knowledge;Lactams;Libraries;lipoteichoic acid;Mediating;member;Membrane;Membrane Proteins;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Methods;microfluidic technology;Microfluidics;Modification;Molecular;Morbidity - disease rate;mortality;Mothers;mutant;Nosocomial Infections;novel;novel strategies;novel therapeutic intervention;Organism;Pathogenesis;Pathway interactions;Physiology;Play;Predisposition;prevent;programs;Proteins;reconstitution;Resistance;Role;screening;signal peptidase;Staphylococcus aureus;Staphylococcus aureus infection;synergism;Technology;Teichoic Acids;Therapeutic;Training;transmission process;transposon sequencing;United States;Up-Regulation;Virulence;Work

PROJECT_TITLE: Subproject 1: Compounds and Pathways for Antibacterial Combinations


PHR: NARRATIVE There is an urgent need for the development of new antibiotic agents to help combat the increasing number of severe infections and the development of resistance. The main objective of this proposal is to study the efficacies and mechanisms of action of compounds that are active even against resistant methicillin-resistant Staphylococcus aureus bacteria that are in a metabolically inactive state and are thus tolerant to conventional antibiotics. These studies have the potential to play a pivotal role in identifying novel targets for drug development.

PI_NAMEs: MYLONAKIS, ELEFTHERIOS  (contact)

PROJECT_TERMS: acute infection;Address;Agonist;analog;Animals;Anthelmintics;Anti-Bacterial Agents;Anti-Infective Agents;anti-microbial drug;Antibiotic Resistance;antibiotic tolerance;Antibiotics;antimicrobial;Bacteremia;Bacteria;Biochemical;Biological Assay;Biophysics;Caenorhabditis elegans;Cell membrane;Cells;Cholesterol;chronic infection;Clinical;Collaborations;combat;Communities;Community-Acquired Infections;Cryoelectron Microscopy;design;Development;diabetes mellitus therapy;drug development;drug discovery;Drug usage;efficacy study;efficacy testing;Enterococcus faecalis;ESKAPE pathogens;Exhibits;FDA approved;Growth;Hospitals;Immunocompromised Host;In Situ;In Vitro;in vivo;Individual;ineffective therapies;Infection;Infectious Skin Diseases;Insulin Antagonists;Insulin-Like-Growth Factor I Receptor;Laboratories;Lead;Lethal Genes;Lipid Bilayers;Membrane;Membrane Fluidity;Membrane Potentials;Metabolic;Methicillin Resistance;methicillin resistant Staphylococcus aureus;microfluidic technology;Modeling;Mothers;Multi-Drug Resistance;multidrug tolerance;Mus;mutant;new therapeutic target;Nosocomial Infections;novel;novel therapeutics;Outcome;Pathway interactions;Permeability;persistent bacteria;Phase;Physiological;Play;PPAR gamma;Predisposition;Probability;Process;programs;Resistance;Resistance development;resistance gene;Retinoids;Role;screening;Sepsis;Staphylococcus aureus;Staphylococcus aureus infection;Structure-Activity Relationship;Subcutaneous abscess;synergism;targeted treatment;Techniques;Therapeutic;Toxic effect;transposon sequencing

PROJECT_TITLE: Subproject 2: Identification of Pathways that Can be Targeted for the Development of Novel Therapies for MRSA


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Cystic Fibrosis;Lung;Natural Products;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Cystic fibrosis (CF) patients have abnormal clearance of viscous mucus due to genetic dysfunction of the Cl- channel, CFTR. We have identified that ginsenosides from Korean Red Ginseng improve epithelial Cl- transport through the alternative TMEM16A Cl- channel pathway. The current proposal will test a ginsenoside TMEM16A potentiator in infected CF rats to demonstrate a new treatment for CF airway disease.

PI_NAMEs: WOODWORTH, BRADFORD ALAN (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Adverse effects;Agonist;Airway Disease;Anions;aqueous;Asthma;ATP Receptors;Biological Assay;Blood specimen;Cells;Chemosensitization;chronic pancreatitis;Chronic Sinusitis;Clinical;Clinical Trials;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;density;desensitization;design;Disease;DNA Sequence Alteration;Dose;Drug Kinetics;effective therapy;efficacious treatment;efficacy evaluation;Embryo;Ensure;Epithelium;Exhibits;experimental study;Functional disorder;Genetic;Ginseng Preparation;Ginsenosides;Goblet Cells;Height;Histologic;Histopathology;Hour;Human;human model;Hydration status;improved;In Vitro;in vivo;indexing;Infection;Inflammatory;Ingestion;Investigation;kidney cell;Knowledge;Koreans;Liquid Chromatography;Lung;Measures;Mediating;Mucociliary Clearance;Mucous body substance;mucus clearance;mucus hypersecretion;Mus;Nasal Epithelium;Nose;novel strategies;Optical Coherence Tomography;Oral;P2Y2 receptor;Panax ginseng;patch clamp;Pathologic;Pathology;Pathway interactions;Patients;Pharmacodynamics;Placebos;Plasma;preclinical study;Property;Pseudomonas;pulmonary function;Randomized;Rattus;response;Role;Saline;Saponins;Second Messenger Systems;Shapes;Signal Transduction;Solid;Sprague-Dawley Rats;tandem mass spectrometry;targeted treatment;Testing;Therapeutic;translation to humans;tripolyphosphate;Uridine;Viscosity

PROJECT_TITLE: A Ginsenoside TMEM16A Potentiator for Cystic Fibrosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Pediatric;Primary Health Care;Telehealth

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Pediatric anxiety disorders are common and severely impair the lives of youth and their families; yet less than half of anxious youth receive any intervention. The goal of this application is to reduce this mental health service gap by enhancing the capacity of primary care providers (PCPs) to identify and reduce anxiety, by refining, assessing the feasibility, and conducting a pilot randomized controlled trial of the Anxiety Action Plan, a brief PCP-delivered intervention to reduce pediatric anxiety.

PI_NAMEs: GINSBURG, GOLDA SUSAN (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Academy;Ache;Address;Adherence;Adult;Advisory Committees;Age;American;Anxiety;Anxiety Disorders;anxiety reduction;anxious;Asthma;Attention deficit hyperactivity disorder;Behavioral;brief intervention;Child;Childhood;childhood anxiety;clinical care;Clinical Treatment;Cognitive Therapy;Communities;community setting;Cost-Benefit Analysis;Costs and Benefits;design;Development;disability;Disease;economic cost;Educational Grants;Effectiveness;effectiveness trial;Elements;evidence base;Evidence based intervention;excessive anxiety;Family;Feedback;follow-up;Funding;Future;Goals;Health Professional;Health Services Accessibility;High Prevalence;Impairment;improved;innovation;Intervention;Knowledge;Location;Measures;Mediator;Medical;medical specialties;Mental disorders;Mental Health;mental health center;Mental Health Services;Methods;Modeling;National Institute of Mental Health;novel;Nurse Practitioners;Nurses;Office Visits;Parents;pediatrician;Pediatrics;Physician Assistants;pilot test;pilot trial;post intervention;Prevalence;preventive intervention;Primary Care;primary care clinic;primary care provider;primary care setting;primary care visit;Provider;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research Personnel;School Nursing;service delivery;service gap;service intervention;Severities;skills;Specialist;Stomach;Surgeon;Technology;Testing;theories;Therapeutic;Training;treatment as usual;United States National Institutes of Health;virtual;virtual delivery;virtual visit;Visit;Work;Youth

PROJECT_TITLE: Enhancing the Capacity of Pediatric Primary Care Providers: A Pilot Trial of Anxiety Action Plan


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: NARRATIVE The enterococci are microbes that are extremely difficult to eliminate from the hospital environment or from sites of infection. Much of this is due to an intrinsic ruggedness that distinguishes them from their ancestors as well as most other species, but the genetic basis for this property is yet to be clearly defined. This proposal identifies unique genes that are shown to be functionally important for enterococcal survival and resistance to antibiotics, and identifies the underlying mechanism so that they can be targeted therapeutically.

PI_NAMEs: GILMORE, MICHAEL S (contact)

PROJECT_TERMS: Abnormal Cell;Affect;Animals;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Appearance;Behavior;Biocide;Bioinformatics;bioinformatics network;Biology;Cell Size;Cell Wall;Cells;cellular imaging;Chromosomes;Collection;Communities;comparative;comparative genomics;Data;Defect;defined contribution;Desiccation;Disinfectants;Distant;Drug Design;Drug Screening;Electronic Medical Records and Genomics Network;Elements;Enterococcus;Enterococcus faecalis;Enterococcus faecium;Environment;Exposure to;Filament;fitness;functional genomics;Gene Silencing;Genes;Genetic;Glean;Goals;Growth;gut colonization;Homeostasis;Homologous Gene;Hospitals;Hypothetical Protein;Image;Image Analysis;Imaging technology;Individual;Infection;Insertion Mutation;insight;laser tweezer;Libraries;Microbe;Microfluidic Microchips;microfluidic technology;Modeling;Modification;Molecular;Morphology;Mothers;Multi-Drug Resistance;mutant;Nature;Noise;Nosocomial Infections;novel therapeutics;Organism;Pathogenesis;Pathway Analysis;Patients;Phenotype;Play;Population;Process;programs;Property;Proteins;Proteome;Proteomics;Publishing;quorum sensing;Recombinants;Regulation;Resistance;Resource Development;Rifampin;Role;Sea;Shapes;Site;Starvation;Stress;targeted treatment;technological innovation;Technology;Testing;Time;trait;transcription factor;transcriptome;transcriptomics;transposon sequencing;Variant

PROJECT_TITLE: Subproject 3: Unique Features of Enterococcus that Confer Intrinsic Resistance


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Air pollution may play a role in the development of Alzheimer's disease and related dementias (ADRD) but our knowledge about mechanisms is limited. Here, we test key underlying pathways, and among them, is the pathway through the olfactory system, a direct anatomic connection for environmental toxicants to reach the brain. We will estimate the effect of air pollution exposure on neurocognitive and olfactory outcomes in 5 well- characterized, longitudinal ADRD cohorts using integrated air pollution exposure data from the MESA Air and MESA Coarse studies, and examine how resultant neuropathology and direct deposition of PM (assessed by advanced microscopy) explains these relationships.

PI_NAMEs: PINTO, JAYANT M;WEUVE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Affect;Aging;Air;Air Pollutants;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anatomy;Animals;Autopsy;Biological Markers;Blood Vessels;Brain;cerebrovascular;Cerebrovascular Disorders;Clinical;coarse particles;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Cohort Studies;Collaborations;Data;Dementia;dementia risk;Deposition;Deterioration;Development;Disease;disorder risk;Electron Microscopy;Evaluation;Exposure to;fine particles;Foundations;Geography;glial activation;Goals;Human;Image;Impaired cognition;Individual Differences;Inflammation;Investigation;Knowledge;Latino;Link;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Measures;Medical;Medical Records;Memory;Metals;Microscopy;Minority;Modeling;multi-ethnic;Nervous System;Neurocognitive;Neurologic;neuropathology;Nitrogen Oxides;novel marker;older adult;olfactory bulb;Olfactory dysfunction;Olfactory Pathways;Olfactory tract;Outcome;Participant;Particulate Matter;Pathologic;Pathology;Pathway interactions;Physiological;pollutant;Population;predictive modeling;Predisposition;Process;Public Health;public health intervention;Records;religious order study;research study;Resources;Risk Factors;Role;Smell Perception;Societal Factors;Specimen;Testing;Tissues;Toxic Environmental Substances

PROJECT_TITLE: Air Pollution and Alzheimer's Dementia: Neuropathologic and Olfactory Mechanisms in Multi-Ethnic Longitudinal Cohorts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative  The Orthopaedic Research Society (ORS) Spine Section is the premier professional body devoted to basic and translational spine research, and an indispensable scientific forum for investigators at all career stages. The objective of these three, annual, half day symposia will be to leverage and expand the mission of the ORS Spine Section in order to catalyze transformative basic and translational spine research through enhanced mentoring, diversity and collaboration across institutions and countries.

PI_NAMEs: SMITH, LACHLAN JAMES (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Artificial Intelligence;Awareness;Back Pain;Biocompatible Materials;Biology;Capital;career;Cellular biology;Clinical;Collaborations;Communities;Complement;Computer Models;Country;COVID-19 impact;COVID-19 pandemic effects;Dedications;design;Development;diagnostic strategy;disability;Discipline;Disease;Drug Delivery Systems;Engineering;Ensure;Environment;Equity;experience;Funding;Future;Genomics;Goals;Healthcare;Hybrids;improved;Individual;innovation;Institution;International;intervertebral disk degeneration;meetings;member;Mentors;Minority;Mission;Molecular Biology;multidisciplinary;Network-based;next generation;Orthopedics;Outcome;Patient Care;Patient-Focused Outcomes;Persons;posters;programs;Regenerative Medicine;Research;Research Personnel;Resources;skills;Societies;Speed;Spinal;success;Surveys;symposium;Techniques;Therapeutic;Time;Travel;Underrepresented Minority;United States National Institutes of Health;Vertebral column;virtual;Work

PROJECT_TITLE: ORS Spine Section Symposia: Enhancing Spine Research throughMentoring, Diversity and Collaboration

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: Narrative Multidrug resistance in S. aureus is an increasing clinical and public health problem that requires additional understanding of its mechanisms of development and spread and establishment of novel targets that may be exploited to develop new effective therapies.

PI_NAMEs: HOOPER, DAVID C (contact)

PROJECT_TERMS: Abscess;Affect;Alleles;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;bactericide;Binding;Binding Sites;CD36 gene;Cell Physiology;Cells;cellular imaging;Ciprofloxacin;Clinical;Collaborations;Communities;Complex;Daptomycin;Development;Drug Efflux;effective therapy;Effectiveness;efflux pump;Enterobacteriaceae;Enterococcus;Enterococcus faecalis;Epithelial Cells;expression vector;Fluorescent Probes;Fluoroquinolones;Fosfomycin;Gastrointestinal tract structure;Gene Chips;Genes;genetic manipulation;Genetic Transcription;Genomics;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;gut colonization;Habitats;Heterogeneity;Hospitals;Human;improved;In Vitro;in vivo;Individual;Infection;interdisciplinary approach;Invaded;Knock-out;Libraries;Life;lipoteichoic acid;local drug delivery;Measurement;Mediating;Medium chain fatty acid;Membrane;Microbial Physiology;Modeling;Mothers;mouse model;Multi-Drug Resistance;Mus;Mutagenesis;mutant;Mutation;novel;overexpression;pathogen;Pathogenesis;Pathway interactions;Pattern;peptide analog;Phagolysosome;Pharmaceutical Preparations;Physiology;Plasmids;Poison;Polymyxins;Population;Predisposition;programs;protein expression;protein protein interaction;Proteins;Public Health;Pump;Reporter;Resistance;Resistance development;resistance mechanism;resistance mutation;response;Rifampin;Role;Site;Skin;Skin colonization;Staphylococcus aureus;structural determinants;Structure-Activity Relationship;Subcutaneous abscess;synergism;Testing;Tetanus Helper Peptide;Tetracycline Resistance;Tissues;TLR2 gene;trafficking;transposon sequencing;Trimethoprim-Sulfamethoxazole;Variant;Work

PROJECT_TITLE: Subproject 4: Role of Pumps in Resistance, Physiology, and Infection


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Psychosis;Sleep Research;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project studies how the psychedelic drug lysergic acid diethylamide (LSD) alters the neurophysiological functions of the sensory and memory neural circuits inside the living brain. Its outcomes will advance our understanding of how sensory and memory functions are impacted by classic hallucinogens, uncover possible risks when such drugs are explored as potential therapeutics for mental disorders such as depression, anxiety disorders and drug abuse, and provide insights into how hallucinatory symptoms in schizophrenia and other psychiatric disorders may be produced and treated.

PI_NAMEs: JI, DAOYUN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Animals;Anxiety Disorders;Area;awake;Behavior;Behavioral;behavioral response;Brain;Cells;Cognition;cognitive function;Cues;Data;Detection;dosage;Drug abuse;drug addiction therapy;Event;Hallucinations;Hallucinogens;Head;Hippocampus;Human;human imaging;imaging study;Immobilization;Impairment;in vivo;insight;interest;Investigational Therapies;Knowledge;Learning;Location;Lysergic Acid Diethylamide;Memory;memory consolidation;Memory impairment;memory process;memory retrieval;Mental Depression;Mental disorders;neural;neural circuit;Neurons;neurophysiology;Neurophysiology - biologic function;novel;novel therapeutics;Outcome;Outcome Study;Pattern;Perception;Performance;Pharmaceutical Preparations;Prefrontal Cortex;Property;psychotic;Rattus;receptor;Research;response;Risk;Rodent;Role;Running;Schizophrenia;Sensory;sensory cortex;Short-Term Memory;Sleep;Sleep Architecture;Slow-Wave Sleep;spatial memory;Symptoms;Task Performances;Techniques;Testing;Therapeutic;Time;Training;treatment strategy;Visual;Visual Cortex;voltage;way finding

PROJECT_TITLE: Neurophysiological impacts of hallucinogens on hippocampal and cortical neural circuits

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE With a highly representative sample of nearly one million adolescents (N=900,000) regularly screened for cannabis use in Kaiser Permanente Northern California’s large integrated healthcare delivery system from 2015-2023, this multi-method study will test whether and how California state recreational cannabis legalization (RCL) and local policies (e.g., retailer bans or caps, product and advertising restrictions, taxes, health warnings) impact adolescent cannabis use and cannabis-related health conditions using a quasi-experimental interrupted time series design. Quantitative results will be complemented by post-RCL interviews with addiction medicine, pediatric, and emergency department clinicians and adolescent focus groups to gain insights into the clinical impacts of RCL on adolescents. Together, results will have immediate public health and clinical implications, providing urgently needed data to identify potentially actionable areas for future policy adaptations and aid decision making for public health practices to reduce adolescent cannabis-related harms.

PI_NAMEs: YOUNG-WOLFF, KELLY CORINNE (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Accident and Emergency department;Accidents;Acute;addiction;Address;Adolescence;Adolescent;Advertising;American;Anxiety;Area;Brain;California;Cannabinoids;Cannabis;Cannabis policy;cigarette smoking;Clinical;clinical care;clinical practice;Communities;contextual factors;Data;Decision Aid;Decision Making;design;Development;Diagnosis;disorder risk;Education;Electronic Health Record;Emergency Department Physician;Emergency department visit;epidemiology study;Event;Focus Groups;Future;Geographic Information Systems;Health;Health Personnel;Health Policy;health service use;health warning;Healthcare;Heterogeneity;high risk;Home;illicit drug use;Individual;innovation;insight;Integrated Delivery of Health Care;Integrated Health Care Systems;Interruption;Intervention;Interview;Intoxication;Knowledge;Laws;Legal;Local Government;Location;Low income;Maps;Marijuana Dependence;marijuana legalization;marijuana use;marijuana use disorder;Marketing;Medical Marijuana;Medicine;meetings;Mental Depression;Mental Health;Methods;motor vehicle injury;National Institute of Drug Abuse;Natural experiment;Parents;Patients;pediatric department;pediatrician;Perception;Poisoning;Policies;Population Heterogeneity;Provider;psychiatric comorbidity;Psychoses;Public Health;Public Health Practice;public health priorities;public health relevance;Quasi-experiment;Recreation;Reporting;Research;respiratory;Respiratory Disease;Respiratory Signs and Symptoms;Risk;Risk Factors;Sampling;Scheme;Schizophrenia;screening;Series;Shapes;standard care;Study models;Subgroup;substance use;Suicide;Syndrome;System;Taxes;Teenagers;Testing;Time;trend;US State;Vehicle crash;Withdrawal;Youth

PROJECT_TITLE: Assessing the Impact of Cannabis Legalization on Adolescent Cannabis Use and Cannabis-Related Health Conditions

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Training dental providers to effectively promote the human papillomavirus vaccine (HPV-V) with their patients could prevent future HPV-related cancer of the mouth and throat in those who become vaccinated. This study will develop HPV-V promotion training and tailored scripts to support dental providers in promoting HPV-V. By testing this intervention in a real-world dental setting, this project has the potential to help increase HPV vaccination rates, reduce HPV-related cancers, and serve as a model for other organizations providing dental care.

PI_NAMEs: MABRY, PATRICIA LOMBARD;RINDAL, D. BRAD (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Behavior;behavior change;behavior measurement;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;Clinic;Critical Pathways;Dental;Dental Care;design;Development;Effectiveness;efficacy testing;efficacy trial;Eligibility Determination;Fright;Future;Goals;head and neck cancer prevention;Health;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Institutional Review Boards;Intervention;intervention effect;Knowledge;lifetime risk;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Mediator;Methods;Modeling;Monitor;National Institute of Dental and Craniofacial Research;Newly Diagnosed;novel;Oropharyngeal;Parents;Pathway interactions;Patients;Perception;Persons;Phase;pilot test;Population;post intervention;Prevalence;prevent;Provider;provider behavior;provider-level barriers;Randomized;randomized, clinical trials;Resources;Safety;Science;Self Efficacy;Surveys;Testing;theories;therapy design;therapy development;Throat Cancer;Training;treatment as usual;Treatment Efficacy;United States National Institutes of Health;Vaccinated;Vaccination;vaccine acceptance;Vaccines;Visit;Work

PROJECT_TITLE: Investigating Behavioral Mechanisms and Efficacy of a Provider-Directed Intervention for HPV Vaccine Promotion in Real-World Dental Settings


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Phthiocerol dimycocerosate (PDIM) are lipids in the outer membrane of the pathogen Mycobacterium tuberculosis that are crucial for defending attacks by the immune system and antimicrobial compounds. The lack of routine screening and selection tools for PDIM levels have led to great uncertainty in experimental work in Mtb, and yielded countless in vivo studies where spontaneous PDIM mutations have led to inexplicable phenotypes. We will develop screening and selection tools to get rid of this issue and use those research instruments to understand PDIMs role in mycobacterial pathogenesis and drug tolerance.

PI_NAMEs: BERNEY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Animals;Antibiotics;antimicrobial;Applications Grants;Atlases;attenuation;Autoradiography;Bacteria;Biological Assay;biosafety level 3 facility;cell envelope;Cell Wall;Cells;Cessation of life;Clinical;Communicable Diseases;Communities;Complex;cost;cost effective;deep sequencing;design;Development;Diagnostic;disease heterogeneity;Disease Progression;drug efficacy;Drug resistance;Drug Tolerance;Engineering;Environment;Equipment;Evolution;experimental study;Exposure to;Frequencies;genetic manipulation;genome sequencing;Growth;Heterogeneity;Hydrophobicity;Immune system;In Vitro;in vivo;Infection;instrument;Laboratory culture;Laboratory Procedures;Libraries;Lipids;Liquid substance;Mass Spectrum Analysis;Membrane;Metabolism;Methods;Modeling;mortality;mouse model;Mus;Mutation;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;Mycobacterium tuberculosis H37Rv;pathogen;Pathogenesis;Pathologic;Permeability;Pharmaceutical Preparations;Phenotype;Population;Population Heterogeneity;Predisposition;prevent;Procedures;Production;Propionates;Protocols documentation;Reproducibility;Research;Role;routine screening;screening;Screening procedure;skills;small molecule;Solid;Structure;Supplementation;Testing;Therapeutic;Thin Layer Chromatography;Time;tool;Uncertainty;vaccine efficacy;Vancomycin Resistance;Virulence;Virulence Factors;wasting;whole genome;Work

PROJECT_TITLE: The PDIM paradox of M. tuberculosis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Mechanistic concepts from model organisms are used to translate ideas for therapeutics, vaccine design, managing infectious diseases and immune pathologies into humans. Mice are one of the most widely used preclinical models of human immunity, and the studies in our proposal will aid in predicting how structural variation between the genomes of model organisms and the human genome contribute to humans acquiring (or losing) cell-type and stimulation-dependent gene expression patterns and functions in immune cells.

PI_NAMEs: WEINMANN, AMY SUSAN (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Affect;Attention;Biomedical Research;Buffers;Categories;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromosomal Rearrangement;Chromosomes;Clinical Trials;combat;Communicable Diseases;Conserved Sequence;Data Set;differential expression;DNA Sequence;Elements;Enhancers;Event;Foundations;Gene Cluster;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;Genes;Genetic;Genetic Enhancer Element;Genome;Genomic approach;Genomics;Grant;Human;Human Genome;human model;Immune;Immune response;Immunity;Immunological Models;Immunologics;Immunology;improved;inducible gene expression;inhibitor;insertion/deletion mutation;insight;Knowledge;Location;Macrophage;model organism;mouse genome;mouse model;Mus;NOS2A gene;novel;pathogen;Pathogenicity;Pathology;Patients;Play;Positioning Attribute;Pre-Clinical Model;preclinical study;preference;pressure;prevent;Primates;promoter;Regulation;Regulatory Element;Research;response;Rodent;Role;Site;Technology;Testing;Therapeutic;tool;Translating;Translocation Breakpoint;Trees;Vaccine Design;Variant

PROJECT_TITLE: Genome organization, evolutionary structural variation, and gene regulation in immunity


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Infectious Diseases;Social Determinants of Health

ORG_CITY: College Station

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Project Narrative Despite the increasingly recognized role of the environment in the spread of virus aerosol particles and controlling many of the pathways that lead to the deposition and resuspension of viruses, the mechanism underlying the effect of the environment is poorly understood. We propose to address this need by using molecular dynamics and computational modeling with the spatial, and temporal collection of aerosolized virus particles to track their deposition and resuspension within a model hospital room at different ventilation configurations. The knowledge gained in the process helps develop better ventilation strategy guidelines to reduce the spread of virus particles in hospitals and mitigate disease transfer in these or other facilities.

PI_NAMEs: KING, MARIA DOBOZI (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TITLE: Mitigation of ventilation-based resuspension and spread of airborne viruses in nosocomial and healthcare settings

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE / RELEVANCE Bacterial infections in skin wounds cause suffering and distress in over 6 million patients in the US each year and incur treatment costs totaling over $25 billion annually. The current arsenal of antibiotics available to treat these infections is now almost empty due to the rise of bacterial resistance. Fundamentally new approaches that move beyond conventional antibiotic strategies and target bacterial virulence rather than cell growth would provide means to address this threat and have substantial impacts on human health; this proposal introduces such a strategy by targeting a chemical signaling process common to bacteria found in wound infections.

PI_NAMEs: BLACKWELL, HELEN E. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abscess;Address;Adhesions;Affect;Animal Model;Animals;Anti-Infective Agents;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Attenuated;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;biodegradable polymer;Biological;Bolus Infusion;Caring;Cause of Death;Cell Density;cell growth;Cells;Chemical Agents;Chemicals;Clinical;Clinical Microbiology;controlled release;design;Development;Disease;Distress;Dose;Drug Delivery Systems;Etiology;experience;experimental study;Explosion;Growth;healing;Health;Hospitals;Host Defense Mechanism;Human;human model;Immune Evasion;in vivo;in vivo Model;infancy;Infection;Infection Control;Infectious Skin Diseases;inhibitor;innovation;intercellular communication;Intercept;interest;Investigation;Knowledge;Lead;Medical;Methods;Microbial Biofilms;Modeling;mouse model;Mus;novel;novel strategies;Outcome;particle;pathogen;Pathogenesis;pathogenic bacteria;Patients;Persons;Pharmaceutical Preparations;Polymers;prevent;Process;Production;Protocols documentation;quorum sensing;Reporting;Research;resistance mechanism;Rewards;Risk;Route;Signal Pathway;Signal Transduction;skin wound;Staphylococcus aureus;Staphylococcus aureus infection;synergism;Testing;Thick;Time;Toxin;Treatment Cost;Validation;Virulence;Work;wound;wound bed;Wound Infection

PROJECT_TITLE: Strategies to Block Skin Wound Infection by Intercepting Bacterial Cell-to-Cell Signaling

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Inflammatory responses in the peripheral and central nervous system appear to play a critical role in the development and progression of Alzheimer’s disease (AD). The ability to non-invasively assess whole-body immune signatures in AD patients is a critical unmet need that will improve diagnosis and disease monitoring, as well as the development and screening of effective therapeutics. This work aims to reveal new insights into the complex neuroimmune interactions involved in AD pathogenesis using novel molecular imaging and immune profiling techniques.

PI_NAMEs: CHANEY, AISLING  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: AD transgenic mice;Address;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Astrocytes;Autopsy;Biological Markers;Blood;Blood Platelets;Bone Marrow;Brain;brain tissue;Cells;Central Nervous System;Clinical;clinical application;Clinical assessments;cohort;comorbidity;Complex;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;Endothelial Cells;Environment;Faculty;Funding;Genes;genome wide association study;Goals;Gold;Heart Diseases;Human;Image;Immune;immune activation;immune function;immune modulating agents;Immune response;Immune Targeting;immunological status;Immunology;immunoregulation;Impaired cognition;improved;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;insight;interest;Investigation;Knowledge;Link;lymph nodes;Macrophage;Magnetic Resonance Imaging;Measures;member;Mentors;Methods;Microglia;mild cognitive impairment;molecular imaging;Monitor;mouse model;multidisciplinary;Multiple Sclerosis;Mus;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;Neuroimmune;neuroinflammation;Neurosciences;novel;Obesity;Outcome;Pathogenesis;patient population;Patients;Peripheral;Peripheral Nervous System;Phase;Phenotype;Play;Positron-Emission Tomography;pre-clinical;Proteins;Protocols documentation;Radiology Specialty;receptor;Reporting;Research Personnel;Resources;response;Risk;Role;screening;Severity of illness;skills;spatiotemporal;specific biomarkers;Specificity;Spleen;stroke model;systemic inflammatory response;Techniques;tenure track;Therapeutic;therapeutically effective;Time;Tissues;tool;Tracer;Training;treatment strategy;uptake;Viral;Work

PROJECT_TITLE: Investigating whole-body innate immune activation in Alzheimer's disease using PET imaging and immune profiling

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rehabilitation;Stroke;Unintentional Childhood Injury

ORG_CITY: DETROIT

ORG_DEPT: PEDIATRICS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  There is a paucity of effective treatments for cerebral palsy and this proposal tests whether an essential enzyme co-factor is involved in brain injury before birth. Using animals in which genes have been altered in their genome by genetic engineering methods, and advanced methods of magnetic resonance imaging, the cellular and genetic basis of brain regional injury will be investigated. These studies will lead to a better understanding how treatment with the same co-factor can reverse the movement disorders caused by insults to the fetal brain before birth.

PI_NAMEs: TAN, SIDHARTHA  (contact);VASQUEZ VIVAR, JEANNETTE M.;XU, JIE

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Abbreviations;Abruptio Placentae;Acute;Animal Model;Animals;antenatal;antioxidant therapy;Behavior;behavioral phenotyping;Birth;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain region;Breeding;burden of illness;cell injury;Cell Therapy;Cells;Cerebral Palsy;Cessation of life;Child;Childhood;Coenzymes;cofactor;Congenital Disorders;CRISPR/Cas technology;Critical Pathways;Cues;Detection;Development;DHFR gene;Diffusion;Dihydrofolate Reductase;dihydropteridine reductase;Discipline of obstetrics;Disease;DNA Sequence Alteration;Early identification;effective therapy;enzyme pathway;Enzymes;Equilibrium;Etiology;Event;Family suidae;fetal;Fetus;fetus hypoxia;Flow Cytometry;Functional disorder;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetic study;Genome;GTP Cyclohydrolase I;Heterozygote;High Pressure Liquid Chromatography;Hospitals;Human;human disease;Human Genetics;Hypoxia;Hypoxic-Ischemic Brain Injury;indexing;Inflammation;Injury;innovation;insight;Institution;Knock-in;Knock-out;Life;Link;Lipopolysaccharides;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Mammals;Methods;Modeling;Molecular;Motor;motor deficit;motor disorder;motor impairment;Motor Manifestations;Movement Disorders;Muscle Hypertonia;Mutation;Nature;neonatal hypoxic-ischemic brain injury;neonate;Neurons;neuroprotection;Neurotransmitters;Newborn Infant;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;Nitrogen;nonhuman primate;Organ;Oryctolagus cuniculus;Outcome;oxidant stress;Oxidants;Oxidoreductase;Oxygen;Parents;Pathogenesis;Pathway interactions;Patients;Pattern;Perinatal;perinatal brain;Perinatal Brain Injury;Periventricular Leukomalacia;Phenotype;Placental Insufficiency;postnatal;Predisposing Factor;Predisposition;Pregnancy;prenatal;Preventive;Preventive treatment;Productivity;rational design;Reperfusion Therapy;Rodent Model;Role;sepiapterin;Sepiapterin reductase;Severities;Siblings;social;Societies;Superoxides;Supplementation;Testing;tetrahydrobiopterin;Tetrahydrobiopterin deficiency;Time;Tissues;Transgenic Organisms;Variant

PROJECT_TITLE: Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic Rabbits

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Substance Misuse;Underage Drinking

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Young adult alcohol misuse is a public health crisis for which new intervention approaches are needed. Smartphone apps are promising as in-the-moment intervention tools, but none are empirically supported for young drinkers. BAC is an important in-the-moment intervention target and there is need for enhanced knowledge that can be addressed via technology as proposed in this grant.

PI_NAMEs: LEEMAN, ROBERT F (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Address;adolescent alcohol misuse;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol use disorder;Alcohols;attentional control;Behavior Therapy;Blood alcohol level measurement;Cellular Phone;citizen science;Compensation;Consumption;Counseling;COVID-19;COVID-19 impact;Data;design;Development;Devices;Disincentive;drinking;Enrollment;Event;field study;forgetting;Grant;Heavy Drinking;heavy drinking young adult;Human;Individual;individualized feedback;Internet;Intervention;Interview;Knowledge;Laboratories;Learning;Location;Motivation;motivational enhancement therapy;multi-component intervention;multimodality;Participant;Persons;Population;precision medicine;preference;Procedures;Public Health;Randomized;Randomized, Controlled Trials;remote delivery;Reporting;Research;Sampling;Self Administration;Self Determination;skills;smartphone application;study population;Technology;technology intervention;Telephone;Testing;Text Messaging;theories;tool;underage drinker;usability;user centered design;young adult;young adult alcohol use

PROJECT_TITLE: Development and Initial Testing of a Multi-Component Breath Alcohol-Focused Intervention for Young Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE In this proposal, we propose to characterize the profile, fate and function of inflamed oligodendrocyte precursor cells (iOPC) that fail to repair myelin and instead develop the capacity to activate cytotoxic CD8 T cells in the brain. We aim to develop therapies that specifically target the signaling pathways leading to the dysregulated iOPC phenotype in order to suppress the damage and facilitate myelin repair.

PI_NAMEs: CALABRESI, PETER A (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adaptive Immune System;Address;Adopted;Adoptive Transfer;Affect;Agonist;Antigen Presentation;Antigens;Area;Astrocytes;Autopsy;Axon;Brain;brain tissue;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cell Differentiation process;cell motility;Cell Physiology;Cell secretion;Cell Survival;Cells;Cellular biology;Central Nervous System;Cephalic;chemokine;Chronic;Clinic;Cross Presentation;Cues;Cuprizone;Cytokine Signaling;cytotoxic;cytotoxic CD8 T cells;cytotoxicity;Demyelinations;Development;disability;Disease;Drug Targeting;effector T cell;exenatide;Experimental Autoimmune Encephalomyelitis;Failure;Funding;Genetic;Genetic Transcription;Globulins;Grant;Immune;immune function;Immunotherapy;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;Interferon Type II;intravital microscopy;Kinetics;Knowledge;Laboratories;Lentivirus;Lymphocyte;Lymphocyte Activation;lymphocyte trafficking;Lymphoid;Maps;Mediating;Meningeal;MHC Class I Genes;Microglia;Modeling;Molecular;Multiple Sclerosis;Mus;Myelin;Neuroglia;Neurological disability;Neurons;neuroprotection;neurotoxic;new therapeutic target;NF-kappa B;NFKB Signaling Pathway;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear Hormone Receptors;oligodendrocyte progenitor;Oligodendroglia;Paper;Pathogenicity;Pathology;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;precursor cell;Process;Property;Receptor Signaling;Refractory;Regulatory Pathway;Relapsing-Remitting Multiple Sclerosis;remyelination;repaired;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;success;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Therapeutic;Therapeutic Intervention;therapy development;Thinking;Thinness;tissue injury;trafficking;Trauma;two-photon;young adult

PROJECT_TITLE: Mechanisms by which effector T cells modulate endogenous remyelination

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The ability to carry out voluntary motor commands diminishes with age, reducing the quality of life and lifespan of individuals. Thus, it is critical to determine the changes within the somatic motor system that contribute to age- related motor deficits. Understanding the changes α-motor neurons undergo during aging is crucial for the future development of treatments that preserve motor function into old age.

PI_NAMEs: CASTRO, RYAN  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Activities of Daily Living;Acute;Affect;Age;age effect;age related;age related changes;Aging;aging biomarker;Astrocytes;Biochemical;Biological Assay;biophysical properties;Cell Aging;cholinergic;Closure by clamp;Complex;Dendrites;Development;Effector Cell;Elderly;Electrophysiology (science);Equilibrium;Experimental Designs;experimental study;Fellowship;Fluorescence;Future;Glutamates;Goals;grasp;Health;Human;human old age (65+);Image;Individual;Institution;Journals;Knowledge;life span;Lipofuscin;Macaca mulatta;Maintenance;Manuscripts;Mentors;Mentorship;Microglia;Molecular;Morphology;Motor;motor control;motor deficit;motor neuron degeneration;Motor Neurons;Motor output;Movement;Mus;neural circuit;Neuroglia;neuron component;neuronal cell body;Neurons;old mice;outcome disparities;Phase;Play;Population;Postdoctoral Fellow;pre-doctoral;preservation;Property;Proteins;Publications;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Rest;Role;Sensory;sensory feedback;Slice;Spinal Cord;symposium;Synapses;System;Testing;therapy development;Tissues;Training and Education;Training Programs;Transgenic Mice;transmission process;Universities;Walking;Whole-Cell Recordings;Work

PROJECT_TITLE: Cellular and molecular changes in the spinal cord that cause motor deficits in old age


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Protein synthesis is misregulated in a number of diseases including cancer and neurodegeneration. I will investigate the features within mRNA that govern protein synthesis. Elucidating this process will lead to a better understanding of many cellular processes from development to adaptation and may also lead to more effective treatments for a variety of diseases.

PI_NAMEs: NIEDERER, RACHEL O. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Untranslated Regions;Affect;Award;Binding;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biophysics;cancer cell;Cell Physiology;Cells;Code;Computing Methodologies;crosslink;Development;differential expression;Disease;Dissection;effective therapy;Elements;Enhancers;experimental study;Functional disorder;Gene Expression;Genes;Genetic study;genome database;Health;Heterogeneity;high throughput screening;Human;immunoregulation;In Vitro;in vivo;Individual;Investigation;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;model organism;Molecular;mRNA Decay;mRNA Translation;Mutagenesis;Nerve Degeneration;novel;Nucleic Acid Regulatory Sequences;Output;Pathology;Pathway interactions;Phase;Play;Positioning Attribute;Post-Transcriptional Regulation;Postdoctoral Fellow;Process;Production;promoter;Protein Biosynthesis;protein expression;Protein Isoforms;Proteins;Reader;recruit;Regulatory Element;Reporter;Ribosomes;RNA;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;skills;System;Technical Expertise;tenure track;therapy development;Training;Trans-Activators;Transcription Initiation Site;transcriptome;Translation Initiation;Translational Regulation;Translations;United States National Institutes of Health;Universities;Untranslated Regions;Untranslated RNA;whole genome;Work;Yeasts

PROJECT_TITLE: Translational control by 5'-UTR elements


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Nanotechnology;Radiation Oncology

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Increasing the radiation dose delivered to rectal cancers treated preoperatively can improve pathological response at the time of surgery and possibly even obviate the need for surgery but this has been challenging to implement in the clinic due to the limited radiation tolerance of the surrounding normal intestinal loops. Gold nanoparticles that preferentially accumulate in tumors offer the possibility to increase radiation dose within the tumor without damaging adjacent normal tissues. To amplify this radiation dose enhancement, we propose to advance clinical translation of a paradigm using gold nanoparticles that home to the tumor, get internalized by receptor-mediated endocytosis, disperse in the cytoplasm via co-administered pharmacological agents, and can be modeled by mathematical techniques that predict the biological consequences of tumor accumulation.

PI_NAMEs: CHO, SANG HYUN;KRISHNAN, SUNIL  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Academia;Address;Artificial Intelligence;Biodistribution;Biological;Cell Death;Cell Nucleus;Cells;chemoradiation;chemotherapy;Clinic;Clinical;clinical implementation;clinical translation;clinically relevant;Computational Technique;Computer Models;Cytoplasm;Data;Dimensions;Disparate;DNA Double Strand Break;dosage;Dose;Double Strand Break Repair;Elements;experience;fluorescence imaging;Foundations;Geometry;Goals;Gold;Grant;high resolution imaging;High-LET Radiation;Home;Human;Immune;Immunotherapy;improved;In Vitro;in vivo;Industry;Injections;innovation;Intestines;Investigation;ionization;irradiation;Kinetics;Knowledge;Literature;mathematical model;Mediating;Mitochondria;Modeling;Molecular;Monte Carlo Method;multidisciplinary;nano;nanoGold;nanoscale;Nanotechnology;Normal tissue morphology;novel;novel imaging technique;Operative Surgical Procedures;Pathologic;pharmacologic;Prediction of Response to Therapy;predictive modeling;Publications;Radiation;Radiation Dose Unit;Radiation Oncology;radiation response;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radiosensitization;receptor internalization;receptor mediated endocytosis;Rectal Cancer;Recurrence;Research Infrastructure;Resolution;response;Roentgen Rays;Solid;Structure;synergism;Techniques;Testing;Time;Tissue Model;Toxic effect;Translating;Translations;Transmission Electron Microscopy;treatment strategy;tumor;tumor DNA;Tumor Tissue

PROJECT_TITLE: Rational translation of gold nanoparticle mediated radiosensitization to the clinic

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative  The purpose of this Phase 1 COBRE proposal is to launch the Center for Molecular Interactions in Cancer (CMIC) at the University of Arkansas for Medical Sciences in Little Rock, Arkansas. The mission of the CMIC is to study molecular features of biomolecules that drive the functional properties of cancer using structural approaches and quantitative analysis of biomolecular interactions. Our short-term goals for Phase 1 are to foster the creation of a thematic multidisciplinary Center and to leverage a faculty mentoring plan, strategic recruitment and cutting-edge core resources to develop a critical mass of investigators that are able to compete for independent extramural funding in health-related research and support the long-term goal of creating a self- sustaining center.

PI_NAMEs: EOFF, ROBERT L (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Affect;American;Arkansas;Automobile Driving;Basic Science;Binding;Biochemical;Biochemical Process;Biomedical Research;Biophysics;Cancer Biology;cancer diagnosis;Cancer Etiology;cancer research center director;cancer therapy;Cell Physiology;Cells;Centers of Research Excellence;Clinical;clinically relevant;Communities;computing resources;Coupling;Data Analyses;Development;Development Plans;Disease;disease model;disorder prevention;Doctor of Philosophy;Education and Outreach;Endowment;Ensure;Environment;Event;Experimental Designs;Extramural Activities;Faculty;faculty mentor;Faculty Recruitment;Fostering;Foundations;Funding;Goals;Growth;Health;high resolution imaging;Human;improved;Infrastructure;insight;Institution;instrumentation;Interdisciplinary Study;interest;Investments;Knowledge;Malignant - descriptor;Malignant Neoplasms;Medical;member;Mentors;Mission;Molecular;Molecular Analysis;multidisciplinary;operation;Pathogenesis;Patient-Focused Outcomes;Phase;Pilot Projects;preclinical study;Preparation;programs;Property;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Sampling;Science;Scientist;single molecule;Structural Biologist;structural biology;Structure;success;synergism;Talents;Teacher Professional Development;Training;Training and Education;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Arkansas;Binding;Biochemistry;Biomedical Research;Biophysics;Cancer Etiology;cancer therapy;career development;Centers of Research Excellence;Department chair;design;Development;Development Plans;DNA biosynthesis;DNA Repair;Doctor of Philosophy;Ensure;Evaluation;Evolution;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Growth;Individual;Infrastructure;Institution;interest;International;Leadership;Longevity;Malignant Neoplasms;Measures;Medical;meetings;member;Mentors;Mission;Molecular;Molecular Biology;Monitor;multidisciplinary;operation;Pediatric Research;Phase;Pilot Projects;Productivity;professor;Program Evaluation;programs;Radiation Oncology;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;structural biology;Structure;success;Teacher Professional Development;Techniques;Technology;training opportunity;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Administrative Core


PI_NAMEs: ENEMARK, ERIC  (contact)

PROJECT_TERMS: Arkansas;Binding;Biochemical Process;Bioinformatics;bioinformatics pipeline;Biological Process;biological systems;Biomedical Research;Cancer Biology;Cancer Etiology;Cancer Research Project;Cell Physiology;Centers of Research Excellence;Charge;Collection;Communities;Complex;computing resources;Core Facility;Coupling;Cryoelectron Microscopy;Data Collection;Dedications;Development;DNA biosynthesis;Doctor of Philosophy;Education;education resources;Educational workshop;Equipment;experience;Experimental Designs;Funding;Future;Goals;Growth;high resolution imaging;Human Resources;Institution;instrumentation;Investigation;Learning;macromolecule;Malignant Neoplasms;Medical;meetings;member;Methodology;Methods;Mission;multidisciplinary;nature center;novel therapeutics;Pathway interactions;Phase;Process;Program Research Project Grants;Property;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Resources;Sampling;Science;Services;structural biology;Structure;success;Techniques;Technology;tool;Training;Training Activity;Training and Education;tumor;Universities;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Core


PI_NAMEs: RANEY, KEVIN DOUGLAS (contact)

PROJECT_TERMS: Address;Arkansas;Automobile Driving;Binding;Biochemical;Biochemical Process;Biological Process;biological systems;Biomedical Research;biophysical properties;biophysical techniques;biophysical tools;Biophysics;Calorimetry;Cancer Biology;Cancer Etiology;Cancer Research Project;cancer therapy;Cell Physiology;Centers of Research Excellence;Charge;Circular Dichroism;Communities;Complex;Core Facility;Coupling;Cues;Data Collection;Dedications;Disease;Doctor of Philosophy;Education;education resources;Educational workshop;Enzymatic Biochemistry;Equipment;experience;Experimental Designs;experimental study;Fluorescence Anisotropy;Fluorescence Microscopy;Funding;Future;Goals;high resolution imaging;Homeostasis;Human Resources;insight;Institution;instrumentation;Investigation;Label;Learning;light scattering;Macromolecular Complexes;macromolecule;Malignant - descriptor;Malignant Neoplasms;Medical;meetings;member;Metabolic;Methodology;Methods;Mission;Molecular;Molecular Sieve Chromatography;multidisciplinary;Nature;nature center;Nucleic Acids;Oncogenic;Pathway interactions;Phase;Photometry;Policies;Process;Program Research Project Grants;Property;Proteins;Reporting;Research;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Resources;response;Role;Science;Services;Signal Transduction;single molecule;Stimulus;stoichiometry;structural biology;Structure;success;Techniques;Technology;Titrations;tool;Training Activity;Training and Education;tumor;Universities;Visualization;Work

PROJECT_TITLE: Biomolecular Interactions Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics

PI_NAMEs: JAMSEN, JOONAS  (contact)

PROJECT_TERMS: Abbreviations;anti-cancer research;Architecture;Binding;Biochemical;Biochemical Process;Biological Assay;biophysical techniques;Biophysics;Breast;cancer cell;Cancer Research Project;cancer therapy;cancer type;Cell Physiology;Cells;Cellular biology;Centers of Research Excellence;Cervical;Colorectal;Complement;Coupling;Cryoelectron Microscopy;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA polymerase beta2;DNA Repair;DNA-Directed DNA Polymerase;Doctor of Philosophy;Double Strand Break Repair;Environment;environmental agent;Evolution;genome integrity;Goals;Health;high resolution imaging;homologous recombination;homologous recombination deficiency;Human;improved;inhibitor;innovation;insight;Kinetics;Lead;Left;Libraries;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;Mutagenesis;Mutation;neoplastic cell;novel;novel strategies;Outcome;Ovarian;oxidative DNA damage;Pancreas;Pathway interactions;Pharmacologic Substance;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;programs;protein protein interaction;Proteins;Proteomics;Reaction;Reactive Oxygen Species;Repair Complex;repair enzyme;repair strategy;repaired;Research;Research Project Grants;Resistance;Resources;Role;Science;small molecule;small molecule inhibitor;structural biology;Structure;success;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;therapy resistant;Time;time use;treatment response;tumor;tumor progression;Work;X-Ray Crystallography

PROJECT_TITLE: Unraveling DNA Polymerase Double-Strand Break Repair Strategies in Cancer


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PI_NAMEs: MIAH, MD SAYEM  (contact)

PROJECT_TERMS: Adjuvant Therapy;Affinity;anti-cancer research;Architecture;Area;Binding;Biochemical;Biochemical Process;Biological Assay;biophysical techniques;Breast Cancer Cell;Cancer Biology;cancer cell;cancer subtypes;career development;Cell Physiology;Centers of Research Excellence;Chemicals;ChIP-seq;chromatin modification;Complex;Coupling;Critical Pathways;crosslink;Deacetylase;Development;Doctor of Philosophy;Epigenetic Process;epigenomics;gene repression;Genetic Transcription;Goals;high resolution imaging;Homeostasis;Human;In Vitro;in vivo;infiltrating duct carcinoma;inhibitor;Injections;Link;MADH2 gene;MADH4 gene;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;Mentors;Metastatic Neoplasm to the Lung;metastatic process;Molecular;mouse model;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;novel;Nucleosomes;Oncogenes;overexpression;Persons;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;pre-clinical;programs;Proliferating;Protein Tyrosine Kinase;Proteins;Proteomics;Publishing;Reporting;Research;Research Project Grants;Signal Transduction;Specificity;structural biology;subcutaneous;success;Tail;Techniques;Testing;TGFB1 gene;therapeutic target;transcription factor;transcriptome sequencing;Transducers;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;tumor;tumorigenesis;Tyrosine Phosphorylation;Veins;Work

PROJECT_TITLE: Defining Breast Tumor Kinase-Dependent Dysregulation of TGF-beta/SMAD Signaling


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Lung;Lung Cancer

PI_NAMEs: RYAN, KATIE  (contact)

PROJECT_TERMS: A549;Adenocarcinoma Cell;Affect;anti-cancer research;Arkansas;Binding;Biochemical Process;biophysical properties;Cancer Cell Growth;Cancer cell line;Cancer Etiology;Cancer Patient;Cancer Research Project;cancer type;cell motility;Cell Physiology;Cells;Centers of Research Excellence;Cessation of life;Chemicals;Coupling;Data;Disease;Distant;Doctor of Philosophy;experimental study;farnesylation;Foundations;Future;Genetic Transcription;Goals;Guanosine Triphosphate Phosphohydrolases;high resolution imaging;In Vitro;in vivo;Incidence;inhibitor;insight;Invaded;knock-down;Lewis Lung Carcinoma;Lung;Lung Adenocarcinoma;lung cancer cell;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Mentors;Metastatic malignant neoplasm to brain;migration;Modeling;Molecular;molecular subtypes;mouse model;Neoplasm Metastasis;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Phosphorylation;Post-Translational Protein Processing;Probability;Prognosis;programs;Property;protein protein interaction;Proteomics;Regulation;Regulatory Pathway;Research;Research Project Grants;rho GTP-Binding Proteins;RNA Interference;ROCK1 gene;Role;Signal Pathway;Signal Transduction;Site;structural biology;Survival Rate;Testing;The Cancer Genome Atlas;tumor;Work;Xenograft procedure

PROJECT_TITLE: Molecular Mechanism of Rnd3 Regulation in Lung Cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Urinary tract infections (UTIs) are one of the most common bacterial infections caused predominantly by uropathogenic Escherichia coli (UPEC). UTIs occur at least once in more than 60% of women with more than 30% of risk for a recurrence within 6 months of initial infection. With the emergence of antimicrobial drug resistance, we are using a mouse model to understand the role of a protein named Mucin 1 (MUC1) in the urinary tract host defense during infection and recovery, in order to develop new antimicrobial-sparing therapies to treat affected patients.

PI_NAMEs: AL-BATAINEH, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Adhesions;Affect;anti-microbial peptide;Antibiotic Resistance;antimicrobial;Apical;Bacteria;bacterial adhesin receptor;Bacterial Infections;Binding;Bladder;Bladder Urothelium;Cell Line;Cell Nucleus;Cells;Clinical;coping;cost;Cultured Cells;Cytoplasmic Tail;Data;Elements;Epithelial Cells;Epithelium;Escherichia coli;Exhibits;Experimental Models;Extracellular Domain;Female;Gastrointestinal tract structure;Genetic Transcription;glycosylation;Goals;Host Defense;Host Defense Mechanism;Human;Immune response;Infection;Infective cystitis;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury to Kidney;insight;Intercalated Cell;Intervention;ischemic injury;Kidney;kidney infection;Knockout Mice;Laboratories;Mediating;Membrane Glycoproteins;Microbe;microbial;Microbial Drug Resistance;Modeling;mouse model;Mucin 1 protein;Mucins;Mucous Membrane;Mus;Names;NF-kappa B;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Pattern;Phagocytosis;Pharmaceutical Preparations;Phosphotransferases;PIK3CG gene;Play;preservation;prevent;Primary Cell Cultures;Production;Proteins;Proximal Kidney Tubules;Publishing;Reaction;receptor;Recovery;Recurrence;Research;Respiratory System;response;Risk;Role;Severities;Signal Transduction;Site;Source;stable cell line;Surface;Tandem Repeat Sequences;Therapeutic;Tissues;Toll-like receptors;trafficking;Transactivation;transcription factor;UMOD gene;United States;urinary;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli;Urothelium;vacuolar H+-ATPase;Woman

PROJECT_TITLE: Role of MUC1 in the host defense against urinary tract infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The proposed studies will investigate mechanisms regulating vacuole biogenesis in notochord cells and their role in vertebrate spine formation in zebrafish and mice. These studies will provide valuable insights into spine biology that will inform treatments for disc disease.

PI_NAMEs: BAGNAT, MICHEL  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adult;Affect;Aging;Automobile Driving;Biogenesis;Biology;Cell Physiology;Cells;Chickens;Chordata;CHS1 gene;Congenital Scoliosis;Conserved Sequence;Cues;Dedications;Defect;Development;Diagnosis;Disease;Docking;Elements;Embryo;Etiology;Experimental Models;Extracellular Matrix;Family suidae;Genetic;genetic analysis;Genetic study;Genetic Transcription;Human;Immune system;insight;Intervertebral disc structure;intervertebral disk degeneration;Knowledge;Link;Lysosomes;Mammals;Mediating;Membrane;membrane biogenesis;Membrane Fusion;Membrane Proteins;Morphogenesis;Morphology;Mus;Nervous System;notochord;novel;novel strategies;nucleus pulposus;Organ;Organelles;Orthopedic Procedures;Osteoblasts;Outcome;Pathology;Pattern;Phosphorylation;Phosphotransferases;Physiological;Play;programs;Proteins;public health relevance;Publishing;Regulation;Rod;Role;scaffold;Site;Specific qualifier value;Specimen;spine bone structure;Stress;Structure;Testing;Thick;tool;trafficking;transcription factor;Transcriptional Regulation;transcriptomics;Vacuole;vertebra body;Vertebral column;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Regulation of notochord vacuole biogenesis: investigating  its role in spine formation and IVD Biology

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Substance abuse disorders including opioid dependence are characterized by an imbalance between the gen- eration and detoxification of reactive oxygen species (ROS) in the brain. In turn, ROS react with cysteine residues and these stress-related modifications often trigger changes in protein structure and function. The research pro- posed here develops and applies an innovative new chemoproteomics approach that will furnish a global portrait S-sulfenated (oxidized) cysteine ligandability in cell-based model of mu opioid receptor (MOR) signaling. The discovery of small molecules that bind to S-sulfenated (oxidized) cysteines in biological targets relevant to MOR signaling should serve as a rich resource for chemical probes and ultimately therapeutics to treat addiction and substance use disorders.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: activity-based protein profiling;addiction;Address;Adverse effects;Affect;Agonist;Alkylation;Alkynes;Analgesics;autooxidation;Benchmarking;Binding;Biological;Biological Assay;Biology;Brain;Cell model;Cells;chemical reaction;chemical resource;Chemicals;chemoproteomics;Chronic;Consumption;Coupled;Cysteine;cysteinesulfenic acid;Dependence;design;Development;Disease;Dopamine;drug discovery;Drug Metabolic Detoxication;Drug usage;Enzymes;Epitopes;Event;experimental study;Foundations;Future;Gel;Generations;Human;Hydrogen Peroxide;Hyperalgesia;improved;innovation;Libraries;Ligand Binding;Ligands;Link;Literature;Maps;Methods;Modeling;Modification;Morphine;mu opioid receptors;mutant;NADPH Oxidase;neuroinflammation;Neurons;novel;Opiate Addiction;Opioid;Opioid Receptor;opioid use;oxidation;Oxidation-Reduction;Oxidative Stress;Pain;Pharmaceutical Preparations;Phosphorylation;Portraits;Post-Translational Protein Processing;Production;Property;protein function;protein structure;Proteins;Proteomics;Rationalization;Reaction;Reactive Oxygen Species;receptor function;Receptor Signaling;Recombinants;Research;Role;screening;Series;side effect;Signal Transduction;Signaling Protein;Site;Site-Directed Mutagenesis;small molecule;Source;Stress;Substance abuse problem;Substance Use Disorder;Sulfenic Acids;Sulfhydryl Compounds;Superoxides;Testing;Therapeutic;therapeutic target;tool;Validation

PROJECT_TITLE: Nucleophile-Fragment Screening for Site-Specific Covalent Ligand Discovery in Opioid Receptor Signaling

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE TRanslational Auditory NeuroScience: LAb-based Training for Empowered Self-efficacy in audiology doctoral students (TRANSLATES) aims to increase the representation of audiologists, including those from underrepresented backgrounds, in the clinician-scientist biomedical workforce. This innovative program will provide audiology doctoral students with an accelerated summer research bootcamp, followed by two semesters of immersive research training in NIDCD-funded laboratories that use diverse research methods and models towards a better understanding of listening in complex environments to increase research self-efficacy. By the end of the five-year program, 25 audiologists will be empowered to be clinician-scientists involved in team-based research and advancing the next generation of hearing healthcare.

PI_NAMEs: PALMER, CATHERINE V (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;Address;Audiology;Auditory;Automobile Driving;base;Behavioral;Belief;bench to bedside;Biomedical Research;biomedical scientist;career;career development;Caring;catalyst;Cells;Clinical;Clinical Research;Cognitive;cohort;Communication;Communication impairment;Complex;Curiosities;Data;data dissemination;deafness;design;Development Plans;Dimensions;Disease;Disparity;doctoral student;Education;education research;Emotional;empowerment;Enrollment;Ensure;Environment;evidence base;experience;Exposure to;Faculty;Feedback;Funding;Goals;Health;health disparity;Health Professional;Healthcare;Hearing;Hearing Tests;Historically Black Colleges and Universities;Human Resources;Impairment;improved;Individual;innovation;International;Intervention;Knowledge;Laboratories;Learning;life span;Link;Maps;Measures;meetings;member;Mentors;Mentorship;Modeling;Monitor;multidisciplinary;Neurobiology;Neurosciences;Neurosciences Research;next generation;operation;Otolaryngology;Participant;Pathway interactions;Patients;Peer Review;Personal Satisfaction;Positioning Attribute;posters;Productivity;Program Evaluation;Program Reviews;programs;Psychology;Publications;Qualifying;Quality of life;recruit;Research;Research Ethics;Research Methodology;Research Project Grants;Research Training;role model;scaffold;Science;Scientist;screening;Self Efficacy;skills;social;standardize measure;Statistical Methods;student training;Students;success;summer research;symposium;System;Techniques;Therapeutic;Thinking;Training;translational goal;Underrepresented Minority;Universities;Update;Work;World Health Organization;Writing

PROJECT_TITLE: TRANSLATES: TRanslational Auditory NeuroScience: LAb-based Training for Empowered Self-efficacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-X (66)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: Project Narrative This project is to develop a cost-effective, efficient, and mobile health detection technology for rapid home testing and point-of-care testing of blood creatine and acetylcholinesterase for assessment of heat-related illness and pesticide exposure using minimally-invasive finger-stick blood. Additionally, we will develop a health education app for farmworkers to learn heat and pesticides-related health information. The goal of this research is to overcome/eliminate the issues associated with farmworker health disparity: physical, economic, infrastructural, knowledge, language, and cultural barriers to healthcare resources and health literacy.

PI_NAMEs: DU, XIUXIA ;WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acetylcholinesterase;Acute;Acute Disease;Address;Adoption;barrier to care;Big Data;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;Bluetooth;Caring;Cellular Phone;Chemical Exposure;Chronic;Chronic Disease;Chronic Kidney Failure;cloud platform;cloud storage;Collaborations;community based participatory research;Community Health;cost;cost effective;cost effectiveness;Coupled;Creatine;Creatinine;Dangerousness;Data;Data Analyses;data sharing;Detection;detection assay;Development;Devices;Diagnosis;diagnostic assay;Disease;Drops;Early Diagnosis;Economics;Education;Electrical Engineering;Electronics;Engineering;Environment;Evaluation;experience;Exposure to;extreme heat;farm worker;field study;Fingers;Florida;General Population;Goals;Grant;hazard;Health;health care availability;Health Disparities Research;health disparity;Health education;health inequalities;health literacy;Health Technology;Healthcare;Heat Stress;Heat Stress Disorders;high risk;Hispanic;Home;home test;Human;improved;Infrastructure;innovation;Intervention;Kidney Diseases;Knowledge;Laboratories;Language;Latino;Learning;Letters;Life Expectancy;Measurement;Measures;Metadata;meter;mHealth;Migrant;minimally invasive;Minor;mobile application;Morbidity - disease rate;mortality;nanosensors;Nanotechnology;nanowire;National Institute of Environmental Health Sciences;new technology;novel strategies;Performance;pesticide exposure;pesticide poisoning;Pesticides;point of care;Point of Care Technology;point of care testing;Poisoning;polyaniline;Poverty;prevent;Public Health;Quality of life;Reduce health disparities;Reporting;Research;Research Project Grants;Resistance;Resources;response;Risk;Risk Reduction;rural area;Sampling;screening;Seasons;Site;Small Business Technology Transfer Research;software development;statistics;Symptoms;System;Technology;technology development;Testing;Time;tool;Translational Research;United States;United States National Institutes of Health;user-friendly;validation studies;Vulnerable Populations;Work

PROJECT_TITLE: Development of point-of-care mobile health technology to reduce heat and pesticides-induced farmworker health disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (O1)]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: ALBANY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT The specific discriminate collateral immunosuppressive NARRATIVE endothelium is a key regulator of multiorgan dysfunction in response to shock. This study seeks to identify the transcriptional and post-transcriptional mechanisms driving endothelial dysfunction in this context in order to the mechanisms that regulate the required immune response for pathogen clearance from those leading to damage. The findings from these studies will provide the basis for the development of new non- therapies to limit organ dysfunction and increase survival after shock.

PI_NAMEs: ADAM, ALEJANDRO PABLO (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Automobile Driving;Bioinformatics;Blood Coagulation Disorders;Cardiovascular Physiology;Cessation of life;Chronic;Clinical;cognitive function;cost effective;Critical Illness;cytokine;cytokine release syndrome;Cytokine Signaling;design;Development;Diagnosis;Edema;Endothelial Cells;endothelial dysfunction;Endothelium;Ensure;Functional disorder;Gene Expression Profile;Genetic Transcription;hemodynamics;Human;IL6 gene;immune function;Immune response;Impairment;improved;Inflammation;Inflammatory;innovation;Intensive Care;Intensive Care Units;Knowledge;Leukostasis;Modeling;mortality;novel;Organ;Organ failure;Outcome;pathogen;Patient Admission;Patients;posttranscriptional;prevent;Proteins;Reaction;Recovery;Renal function;Research;Resolution;response;Role;Sepsis;Septic Shock;Severities;Shock;Signal Pathway;Signal Transduction;Source;Specimen;STAT3 gene;Syndrome;Therapeutic;tool;Transgenic Mice;translatome;Vascular Diseases

PROJECT_TITLE: Endothelial mechanisms of multiorgan dysfunction

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

PHR: PROJECT NARRATIVE Social recognition is essential for navigating human relationships, and impairments in this ability contribute significantly to difficulties faced by patients with neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder and dementia. This research addresses how cortical processing organizes sensory information that distinguishes individuals, a prerequisite for making behavioral decisions in social groups, and thereby makes a fundamental contribution to our broader understanding of brain mechanisms that enable social behavior. Moreover, this work lays a foundation for intensive investigations of olfactory processing of natural stimuli, with the promise of significantly increasing the biological relevance of our insights and, by extension, the translational relevance of our work for patients with olfactory dysfunction.

PI_NAMEs: BOLDING, KEVIN A (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Animals;Area;autism spectrum disorder;Behavior;Behavioral;behavioral response;Biological;Brain;Calcium;Calibration;Chemicals;Classification;Code;Complex;Cues;Dementia;density;designer receptors exclusively activated by designer drugs;Development;Discrimination;Disease;Disinhibition;Electrodes;Elements;Enterobacteria phage P1 Cre recombinase;Environment;Evolution;experimental study;Feedback;Fiber;fitness;flexibility;Foundations;Genetic;Goals;Head;House mice;Human;Image;Impairment;improved;In Vitro;Inbred Strain;Individual;insight;Investigation;Knowledge;Measures;microendoscope;Mus;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Neuropeptide Receptor;Neurosciences;Nose;novel;odor discrimination;Odors;olfactory bulb;Olfactory Cortex;Olfactory dysfunction;Olfactory Pathways;operation;optogenetics;Outcome;Oxytocin;Oxytocin Receptor;paraventricular nucleus;Partner in relationship;Patients;Performance;Photometry;piriform cortex;Population;Population Dynamics;preference;processing speed;Property;Research;Resources;response;Role;Sampling;Sensory;sex;Signal Transduction;Smell Perception;social;Social Behavior;Social Behavior Disorders;Social Environment;social group;Social Identification;Social Interaction;social observations;Source;Stimulus;System;Testing;Time;Training;translation to humans;Viral;Volatilization;Work

PROJECT_TITLE: Cortical odor processing for social recognition

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative The disease burden for women in the US is higher than that for men across a broad range of conditions, including addiction and depression, certain types of cancers, Alzheimer’s disease, and many others. Significant advances on these challenging problems increasingly relies on interdisciplinary research that invokes a variety of techniques and diverse expertise. To address this challenge, we propose a COBRE center that develops a critical mass of researchers across multiple disciplines, united by the theme of leveraging large data sets for advancing biomedical research that will ultimately increase health equity for women.

PI_NAMEs: DESAIRE, HEATHER R (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: addiction;Address;Alzheimer's Disease;Alzheimer's disease risk;behavioral and social science;Behavioral Sciences;Big Data;Biology;Biomedical Research;burden of illness;cancer type;Caregivers;Centers of Research Excellence;Chemistry;Collection;Communication;COVID-19 pandemic;Data Science;Data Set;Detection;Development;Disadvantaged;Discipline;Disease;Disparity population;Ecosystem;Education;Educational workshop;Eligibility Determination;Environment;Equity;Estrogens;experience;Faculty;Funding;Future;Geography;Goals;Grant;Hand;Health;health equity;health inequalities;high risk;human capital;improved;Individual;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Kansas;Laboratories;large datasets;Lead;Life Style;Link;Malignant neoplasm of ovary;men;Mental Depression;Mentors;Mind;Nerve Degeneration;next generation;novel;Organization administrative structures;Pilot Projects;Policy Maker;Premenopause;Probability;programs;Public Health;Race;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Risk;Rural;rural area;Scientist;Services;sex;Sex Differentiation;Social Sciences;symposium;Techniques;Telemedicine;tenure track;tool;United States National Institutes of Health;Universities;University adminstration;Vision;voucher;Woman;Women's Health;Writing

PROJECT_TITLE: Leveraging Big Data to Improve Women's Health (BD-WH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD);Women's Health Research

PROJECT_TERMS: Address;Agreement;arm;Big Data;Biomedical Research;Centers of Research Excellence;Chemistry;Collaborations;Communication;Data Science;Data Set;design;Development;Ensure;Evaluation;experience;Faculty;Fostering;Funding;Goals;Grant;human capital;improved;innovation;Institution;Kansas;meetings;Mentors;Monitor;operation;Ownership;Pilot Projects;Program Development;programs;Psychology;recruit;Research;Research Personnel;Research Project Grants;Research Support;Science;skills;Sociology;Strategic Planning;success;symposium;Talents;tenure track;Training;United States National Institutes of Health;Universities;Women's Health;Writing

PROJECT_TITLE: Administrative and Professional Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Women's Health Research

PI_NAMEs: GINTHER, DONNA K. (contact)

PROJECT_TERMS: Address;Applications Grants;Behavior;Behavioral;Behavioral Sciences;Big Data;Biological Assay;Biology;Biomedical Research;Censuses;Centers of Research Excellence;Collaborations;Communities;complex data;Computer software;Data;Data Analyses;data centers;Data Discovery;data format;Data Science;Data Set;Data Sources;Development;Education;Eligibility Determination;Employment;Environment;experience;Faculty;faculty mentor;faculty research;faculty support;family structure;Free Will;fundamental research;Funding;Future;genetic information;Goals;Health;Health Insurance Portability and Accountability Act;health record;Health Sciences;Home;improved;Infrastructure;innovation;Interdisciplinary Study;Kansas;Link;Marital Status;Mentors;Methodology;Methods;Outcome;Personal Satisfaction;Phase;Pilot Projects;Policies;power analysis;Productivity;Records;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resources;Scientist;Services;social;Social Sciences;Statistical Data Interpretation;Students;success;Surveys;Time;Universities;Women's Health;Work

PROJECT_TITLE: Biomedical Data Sets and Services Core