PROJECT_TERMS: Abdomen;Biopsy;Cancer Intervention;Cancerous;Carcinoma;Clinical;clinical center;Clinical Trials;Computer software;Core Biopsy;Custom;Cytology;design;Detection;Devices;Diagnosis;diagnostic accuracy;Electromagnetics;Elements;Endoscopy;Enhancing Lesion;Excision;Feedback;first-in-human;Fluorescence;fluorescence imaging;Future;Goals;Hepatic;Human;human study;Image;image guided therapy;in vivo;in vivo Model;Indocyanine Green;Institutional Review Boards;Intervention;Intravenous;Lesion;Liver;liver biopsy;liver cancer model;Liver diseases;Liver neoplasms;Localized Malignant Neoplasm;Location;Metastatic Neoplasm to the Liver;Methods;minimally invasive;Modeling;molecular imaging;Needle biopsy procedure;Needles;Nodule;novel;Operative Surgical Procedures;optical imaging;Optics;Patient Recruitments;Patients;Pharmaceutical Preparations;point of care;point of care testing;Point-of-Care Systems;Primary carcinoma of the liver cells;Process;real-time images;regenerative;Regulatory Pathway;Sampling;Signal Transduction;Specific qualifier value;Specimen;Structure;System;Technology;technology platform;Time;Tissues;translational clinical trial;United States National Institutes of Health;Validation;Visualization;Woodchuck;Work

PROJECT_TITLE: Optical and electromagnetic tracking guidance for hepatic interventions


ACTIVITY: ZIA

ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Hematology;Infectious Diseases;Kidney Disease;Organ Transplantation;Prevention;Sepsis;Transplantation

PI_NAMEs: STAR, ROBERT A (contact)

PROJECT_TERMS: Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Animal Model;Biological Markers;Biopsy;Blood Tests;candidate identification;candidate marker;Characteristics;clinical diagnostics;Collaborations;Contrast Media;diagnostic assay;Disease;Early Diagnosis;Elements;exosome;follow-up;Functional disorder;Graft Rejection;Hepatotoxicity;Injury to Kidney;Kidney;Kidney Diseases;Lung Transplantation;Magnetic Resonance Imaging;Methods;microRNA biomarkers;MicroRNAs;Monitor;Nephrons;nephrotoxicity;next generation sequencing;Patients;Plasma;Property;Proteins;Proteomics;Sampling;Sepsis;Source;Techniques;Testing;treatment response;Urine;Validation;Work

PROJECT_TITLE: Early Detection Of Renal Injury


NIH_SPENDING_CATS: Headaches;Neurosciences;Pain Research

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: JENSEN, ROBERT  (contact)

PROJECT_TERMS: Address;Agonist;Alcohols;antagonist;Area;Bombesin Receptor;bombesin receptor subtype 3;British;Central Nervous System Diseases;Chimera organism;Cholecystokinin;Classification;Clinical Trials;Consensus;Data;Ectopic Expression;Family;Family member;G-Protein-Coupled Receptors;Gastrin releasing peptide;Gastrins;Gastrointestinal Hormone Receptors;Gastrointestinal Hormones;Goals;Headache;Hormones;human disease;Journals;Lead;Ligands;Literature;Migraine;Molecular;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;neuromedin B;Neurotransmitters;new therapeutic target;Paper;Pathogenesis;Peptides;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Physiological;pituitary adenylate cyclase activating polypeptide;Post-Traumatic Stress Disorders;Protocols documentation;receptor;receptor expression;Reporting;Research Personnel;response;Role;Safety;Satiation;Secretin;side effect;Signal Transduction;Site-Directed Mutagenesis;smoking addiction;Somatostatin;Specificity;State-of-the-Art Reviews;Therapeutic;Therapeutic Uses;Time;tool;United States National Institutes of Health;Update;Vasoactive Intestinal Peptide

PROJECT_TITLE: Characterization And Pharmacology Of Receptors For Gastrointestinal Peptides


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Neurosciences;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Acinar Cell;Acinar cell tumor;Acinus organ component;Actins;Address;Affect;Area;Bombesin;Bombesin Receptor;cell growth;Cell Physiology;Cells;Central Nervous System;Cholecystokinin;cofilin;Consensus;Development;Endothelin;Enzymes;Exocrine pancreas;experimental study;Family;G-Protein-Coupled Receptors;gastrointestinal;Gastrointestinal Hormones;Gastrointestinal tract structure;genetic regulatory protein;Growth;Growth Factor;Growth Factor Receptors;Hormones;Human;insulin secretion;islet;Malignant Neoplasms;MAP Kinase Gene;MAPK8 gene;Mediating;Mediator;migration;Motility;neoplastic;Neurotensin;Neurotransmitters;novel;novel therapeutic intervention;Pancreas;pancreatic cancer cells;Pancreatitis;Paper;Pathologic Processes;Peptides;Pharmacology;Physiological;pituitary adenylate cyclase activating polypeptide;Play;Positioning Attribute;Process;Proliferating;Protein Tyrosine Kinase;Protein-Serine-Threonine Kinases;receptor;Receptor Protein-Tyrosine Kinases;response;Role;Serine;Serine/Threonine Phosphorylation;Signal Transduction;Tissues;Transactivation;Transfection;Tumor Cell Line;tumor growth;Tyrosine;Tyrosine Phosphorylation;tyrosine receptor;Writing

PROJECT_TITLE: Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factors


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Neurosciences;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: absorption;Acids;Address;American;Area;Case Study;Clinical;Collaborations;Critiques;Data;Databases;Development;Diagnosis;Disease;Dose;Drug usage;European;follow-up;Food;Gastrinoma;Goals;Guidelines;Individual;Islet Cell Tumor;Knowledge;Literature;Malignant - descriptor;Medical;Medical Societies;Medicine;Molecular;Monitor;Multiple Endocrine Neoplasia Type 1;Natural History;Neuroendocrine Tumors;Operative Surgical Procedures;Paper;Patients;pet animal;Pharmaceutical Preparations;Positron-Emission Tomography;Prognosis;Prognostic Factor;Prospective Studies;Protocols documentation;Published Comment;Series;side effect;Societies;Textbooks;Time Management;tumor;Tumor Biology;Vitamin B 12 Deficiency;Writing;Zollinger-Ellison Syndrome

PROJECT_TITLE: Diagnosis, Natural History, Management, tumor biology of Gastrinomas/PETs/Neuroendocrine tumors


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Fibroid Tumors (Uterine);Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Ovarian Cancer;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: SANDLER, DALE P (contact)

PROJECT_TERMS: Accounting;Acne;Adolescent;Adult;Affect;African American population;Age;aged;Agreement;Air Pollutants;Air Pollution;Area;Biological;biological age;Biological Aging;black women;Blood;Blood Cells;Blood Donations;Blood Pressure;Body mass index;breast cancer diagnosis;Breast Cancer gene;Breast Cancer Risk Factor;Breast Cancer survivorship;Burn injury;Chemical Exposure;Chemicals;Childhood;Chromium;Chronic Disease;coarse particles;cohort;Collaborations;Collection;Complex;Computer Assisted;conditioning;Data;Data Pooling;depressive symptoms;deprivation;design;Diagnosis;Diagnostic;Diet;Dietary Factors;dietary supplements;Discrimination;Disease;Dust;Dyes;early adolescence;Education;endometriosis;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Ethnic Population;Etiology;Exercise;experience;Exposure to;falls;Feces;Female;Fibroid Tumor;fine particles;follow-up;Frequencies;gene environment interaction;Genes;Genetic;genetic risk factor;Genitalia;Genomics;Goals;good diet;Gynecologic;Hair;Health;Home visitation;Hormonal;Hormones;Human;Hypertension;Hysterectomy;indexing;Inflammatory Bowel Diseases;interest;International;Investigation;Iron;Lead;Leadership;Leisures;Life;Light;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;Measurement;Measures;Medical;Medical Records;Metals;Nail plate;National Institute of Environmental Health Sciences;Neighborhoods;never smoker;Nitrogen Dioxide;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Occupations;Onset of illness;Paper;Parkinson Disease;Participant;Perfume;Perimenopause;personal care products;Pesticides;Physical activity;Positioning Attribute;Premenopause;prospective;Prospective Studies;Publishing;Questionnaires;Race;racial population;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;research study;response;Retrospective Studies;Risk;Risk Factors;Role;Running;Sampling;Seasons;Sister;Skin Care;sleep pattern;Smell Perception;social factors;social health determinants;Socioeconomic Status;Sports;Structure of nail of toe;Surveys;Survivors;Talc;Telephone Interviews;Testing;Time;treatment response;Trees;Tumor Tissue;Urine;Uterine Cancer;Uterine Fibroids;Vaginal Douching;Walking;White Women;Woman;Women's Health;Wood material

PROJECT_TITLE: Environmental and Genetic Risk Factors For Breast Cancer: The Sister Study


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Prevention

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: UMBACH, DAVID M (contact)

PROJECT_TERMS: Algorithms;Alleles;Cataloging;Complex;Control Groups;coping;Data;Data Discovery;design;detection method;Disease;disorder risk;Environment;Environmental Risk Factor;gene environment interaction;Gene Frequency;gene interaction;Genes;Genetic;Genetic Epistasis;genetic makeup;Genetic Predisposition to Disease;Genetic Programming;genetic variant;genome-wide analysis;Genotype;Individual;Investigation;Machine Learning;method development;Modification;Nuclear Family;offspring;Paper;Parents;Population;Procedures;Research Personnel;Risk;Siblings;simulation;Statistical Methods;Structure;Techniques;Testing;Time;tool;Work

PROJECT_TITLE: Statistical Methods For Gene/environment Interaction And Genetic Susceptibility


PROJECT_TERMS: Body mass index;Breast;Clinical Research;Collaborations;Data Collection;Development;epidemiology study;Estrogens;Growth;Human Development;Infant;Measures;Neonatal;neonate;novel;Paper;Pediatric Hospitals;Phenols;Philadelphia;Publications;Publishing;Role;soy;Statistical Methods;Techniques;Testis;Testosterone;ultrasound;Urine;Work;World Health Organization

PROJECT_TITLE: Statistical Methods In Human Development/clinical Studies


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lupus;Nutrition;Obesity;Prevention;Rare Diseases;Rural Health;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: 12 year old;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;African American;Age;age group;Aging;aging related disease;agricultural community;Agriculture;Anti-citrullinated peptide antibody;Antigen Presentation;Antinuclear Antibodies;Autoantibodies;Autoimmune Diseases;Autoimmunity;Baltimore;Brazil;cancer risk;caregiving;Chemicals;Chronic Disease;Chronic Kidney Failure;Clinical;cohort;Collaborations;contextual factors;Cross-Sectional Studies;Data;Data Analyses;Data Set;Death Certificates;Dermatomyositis;Diabetes Mellitus;Disease;disease registry;disorder subtype;DNA;early life adversity;Enrollment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epidemiology;Event;Expenditure;Exposure to;Farm;farmer;Fertilizers;field study;Focus Groups;follow-up;Health;Health Surveys;Hobbies;Hormonal;Hospitalization;human old age (65+);Hygiene;Hypertension;Immune;Incidence;Individual;Kidney;Kidney Diseases;large cell Diffuse non-Hodgkin's lymphoma;Life;Longitudinal cohort;Longitudinal Studies;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;men;Metals;Morality;mortality;multiple chronic conditions;Myositis;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Antigens;Nutrition Surveys;Obesity;Occupational;Occupational Exposure;Occupations;Outcome;Oxidative Stress;Participant;Partner Abuse;Patients;Peptide antibodies;Persons;Pesticides;Phenotype;Polychlorinated Biphenyls;Population;population survey;Predisposition;Prevalence;programs;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;psychosocial stressors;Public Health;Research;Research Personnel;Rheumatoid Arthritis;Risk;Risk Factors;Role;Sampling;Sex Differences;sex variable;Silicon Dioxide;Smoker;Social support;sociodemographic factors;Solvents;Stressful Event;Subgroup;Sunscreening Agents;systemic autoimmune disease;Systemic Lupus Erythematosus;Time;Time trend;traumatic stress;trend;Universities;UV Radiation Exposure;Vitamin D;Woman;Women's Health;young adult

PROJECT_TITLE: Environmental Exposures And Risk For Cancer and Chronic Diseases In Adults


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Inflammatory Bowel Disease;Kidney Disease;Lung;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: 21 year old;active lifestyle;Acute;Address;Age;aged;Agricultural Health Study;Agriculture;Algorithms;Alzheimer's Disease;Animal Feed;Antinuclear Antibodies;Asthma;Autoimmune Diseases;autoimmune rheumatologic disease;Biological Markers;Black Populations;Black race;Breast;cancer risk;cancer type;Cardiovascular Diseases;Cause of Death;Cells;Censuses;Characteristics;Chemicals;Child;Childhood;Chlorinated Hydrocarbons;Chronic;climate change;climate impact;climate-related exposures;cognitive function;cohort;Collaborations;Communities;comparison control;Crohn's disease;dalton;Data;Data Pooling;Databases;Dementia;Diabetes Mellitus;Diagnosis;dietary nitrate;Dietary Nitrite;disability;Disasters;Disease;DNA;drinking water;Elderly;eligible participant;End stage renal failure;Enrollment;Environmental Risk Factor;Epidemic;Event;Exposure to;Family;Farm;farmer;Female;follow-up;Food;Frequencies;Genetic;Genetic study;glyphosate;hazard;Health;health disparity;healthy lifestyle;Heat Stress;Herbicides;Herpes zoster disease;high risk;Hospitalization;House Dust;Humidity;Immune;Immune System Diseases;Incidence;indexing;Infection;infection risk;Inflammatory Bowel Diseases;Information Systems;Injury;Insecticides;Iowa;Kidney;Kidney Diseases;kidney dysfunction;Licensing;Life Style;Link;Locales;London;longitudinal, prospective study;lung health;male;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;Measures;Mediating;Medical Records;Medicare;Medicare claim;member;Michigan;microbial;microbial composition;microbiome;mortality;National Cancer Institute;National Institute for Occupational Safety and Health;National Institute of Environmental Health Sciences;neoplasm registry;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurological outcome;Nitrates;Nitrites;North Carolina;novel;Occupational Exposure;older adult;Olfactory dysfunction;operation;Organophosphates;Outcome;Oxidative Stress;Pain;Parkinson Disease;Participant;Patient Self-Report;pesticide exposure;Pesticides;Population;Positioning Attribute;pre-clinical;Preparation;Privatization;Processed Meats;Publishing;pulmonary function;Questionnaires;racial disparity;Reporting;Research;Research Personnel;research study;resilience factor;Resistance;respiratory;Respiratory Disease;Respiratory Signs and Symptoms;response;Rheumatoid Arthritis;Risk;Risk Factors;Role;Sampling;Sampling Studies;Shotguns;Sjogren's Syndrome;social vulnerability;Spouses;Stress;stressor;Subgroup;Surveys;Symptoms;Systemic Lupus Erythematosus;Temperature;Thyroid Diseases;Thyroid Gland;Time;Ulcerative Colitis;United States Environmental Protection Agency;Universities;Update;urinary;Vital Statistics;Water;Weather;whole genome;young adult

PROJECT_TITLE: Health Effects Of Exposures In Agriculture


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: SHOCKLEY, KEITH  (contact)

PROJECT_TERMS: Adverse effects;Agonist;Algorithms;Analysis of Variance;beta-Lactamase;Biochemical;Biological Assay;Categories;Cells;Chemicals;Classification;Cluster Analysis;Complement;Complex;cost;cytotoxicity;Data;Data Set;Diagnostic;Dimethyl Sulfoxide;Disease;Dose;Drug Industry;Entropy;Environment;environmental chemical;Equation;Equipment and supply inventories;Estrogen Receptors;Evaluation;experimental study;Flare;Generations;heuristics;high throughput screening;Human;improved;In Vitro;in vivo;Individual;interest;Libraries;Luciferases;Measurement;Measures;Methods;Modeling;National Center for Advancing Translational Sciences;National Toxicology Program;Noise;nonlinear regression;novel;Parameter Estimation;Pattern;Pharmacologic Substance;Phase;Play;Quality Control;rate of change;Reader;Regression Analysis;Reporter Genes;Reproducibility;Residual state;response;risk minimization;Role;Running;Science;Shapes;Signal Transduction;simulation;Specific qualifier value;Structure;Subgroup;System;Testing;Titrations;Toxicity Tests;Toxicology;trustworthiness;Uncertainty;user-friendly;Vision;Visualization;web app

PROJECT_TITLE: Analysis of Quantitative High Throughput Screening Data


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

PROJECT_TERMS: Age Years;Agreement;Alabama;Anxiety;Area;Back;Biological;Blood;Blood Pressure;Calibration;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chemical Exposure;chemical spill;Chemicals;Chromium;cigarette smoking;Clinic;Clinic Visits;Clinical;Clinical assessments;clinical examination;Clip;Collaborations;Collection;Communities;Coronary heart disease;Data;Data Collection;Databases;depressive symptoms;Dermal;Disasters;Distress;DNA Damage;DNA Methylation;Economics;Emergency Situation;Enrollment;Epigenetic Process;epigenome;Equipment and supply inventories;Evaluation;Event;experience;Explosion;Exposure to;fine particles;Flare;Floods;follow-up;Gases;Green space;gulf coast;hazard;Health;heart disease risk;Hematology;Hepatic;Home;Home visitation;Human;Hurricane;Hydrocarbons;Immunologics;Impairment;In Situ;indexing;Individual;Inductively Coupled Plasma Mass Spectrometry;interest;Interview;Joints;Lead;Leg;Leukocytes;Life Style;Link;Location;Longterm Follow-up;Louisiana;male;Malignant Neoplasms;man-made disasters;Manganese;marijuana use;marine;Measurement;Measures;medically underserved population;Mental Depression;Mental Health;Mercury;Meta-Analysis;Metals;Methods;Mexico;Mood Disorders;Motor;National Health and Nutrition Examination Survey;neoplasm registry;Nerve;Nervous System Physiology;Neurologic;Neurologic Effect;never smoking;Occupations;Oils;Outcome;Participant;Persons;Petroleum;Phase;physical symptom;Population;Post-Traumatic Stress Disorders;Process;Public Health Schools;Publications;pulmonary function;Pulmonary function tests;Questionnaires;Recording of previous events;Registries;Renal function;Reporting;Reproductive Health;Research;Research Personnel;respiratory;response;Risk;sample collection;Sampling;Sensory;Short-Term Memory;Site;social;socioeconomic disadvantage;socioeconomics;solar radiation;Stress;Structure of nail of toe;study population;Styrenes;Suggestion;sustained attention;System;Telephone;Testing;Toes;toxicant;United States National Aeronautics and Space Administration;virtual;volatile organic compound;Volatilization;Water;Work

PROJECT_TITLE: Gulf Longitudinal Follow-up (GuLF) Study


NIH_SPENDING_CATS: Lung;Sleep Research

PROJECT_TERMS: Adult;Affect;age difference;Agriculture;airway inflammation;Apnea;Back;Characteristics;Chemicals;Chronic;Clinical;Collaborations;Data;Data Analyses;Development;Dose;Down's Syndrome;Electroencephalography;Electronic Health Record;Environmental Health;Epidemiology;Exposure to;Goals;health record;House Dust;Individual;Laboratories;Laboratory Study;London;lung health;Metagenomics;Methods;microbial signature;microorganism;National Institute of Environmental Health Sciences;Obstructive Sleep Apnea;Patients;pulmonary function;Research Personnel;respiratory health;response;risk prediction;Scientist;Sex Differences;Side;Sleep;Software Tools;Statistical Methods;Supination;Symptoms;Techniques;Work

PROJECT_TITLE: Statistical techniques applied to environmental health sciences


PROJECT_TERMS: adenoma;Age;Archives;Bioinformatics;Biological Assay;carcinogenicity;Carcinoma;Chemical Exposure;Cholestasis;Data Analyses;design;Diethylhexyl Phthalate;DNA Microarray Chip;Event;experimental group;Exposure to;Freezing;Gene Chips;Gene Expression Profiling;Genetic Transcription;Goals;Hepatic;High Prevalence;improved;Incidence;interest;Micro Array Data;National Toxicology Program;Nuclear Receptors;Pancreas;Pathway interactions;phthalates;Rattus;response;Rodent;RXR;Sampling;sex;Statistical Methods;Tissue Sample;Toxicology;tumor

PROJECT_TITLE: DNA Microarray Data Analysis


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: MOTSINGER-REIF, ALISON  (contact)

PROJECT_TERMS: Area;Clinical Research;Collaborations;Epidemiology;Epigenetic Process;Gene Expression Profiling;Manuscripts;metabolomics;method development;Methods;National Institute of Environmental Health Sciences;Paper;Reporting;Research Personnel;Science;Scientist;statistics;Work;Writing

PROJECT_TITLE: Collaborative Applied Statistics


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PROJECT_TERMS: Affect;anti-CD20;Antineoplastic Agents;B-Lymphocytes;Biological Models;Cancer Center;Characteristics;Collaborations;colon cancer patients;Colorectal Cancer;cost effectiveness;Development;Disease;doctoral student;Dose;Follow-Up Studies;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome wide association study;Glioblastoma;Glioma;Goals;improved;in vivo;Link;lymphoblastoid cell line;Malignant Neoplasms;Methodology;MGMT gene;Modeling;Monoclonal Antibody Therapy;Mutation;North Carolina;outcome prediction;oxaliplatin;patient response;Patient-Focused Outcomes;Patients;Pharmacogenomics;potential biomarker;predictive marker;prednisolone;Research;Resistance;response;success;survival prediction;temozolomide;Therapeutic;Toxicogenomics;trait;Treatment outcome;tumor;Universities;Work

PROJECT_TITLE: Statistical Genetics of Dose Response Traits


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Algorithms;base;Bayesian Modeling;Biological;Biological Process;Cells;Chemicals;Code;Collaborations;Complex;computational toxicology;Computer software;COVID-19 risk;Data;data reduction;Data Set;detection method;Development;Dose;Ensure;epidemiology study;flexibility;Future;gene environment interaction;gene interaction;Genes;Genetic Programming;genome wide association study;Genomics;gradient boosting;high dimensionality;improved;improved outcome;indexing;Machine Learning;metabolomics;method development;Methods;microbiome;Modeling;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;open source;Performance;Poly-fluoroalkyl substances;Polymorphism Analysis;programs;Quantitative Trait Loci;Research;response;Sampling;Single Nucleotide Polymorphism;single-cell RNA sequencing;Surveys;Testing;tool;Toxic effect;Toxicogenomics;Toxicology;trend;usability;Visualization;Visualization software;Weight;Work

PROJECT_TITLE: Methods development for "Omics" data


NIH_SPENDING_CATS: Aging;Cardiovascular;Diabetes;Genetics;Heart Disease;Human Genome;Hypertension;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: African;African ancestry;Anti-Hypertensive Agents;biobank;Blood Glucose;blood glucose regulation;blood lipid;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Chromosome Mapping;Clinic;Clinical Trials;cohort;Collaborations;comorbidity;Complications of Diabetes Mellitus;Coupled;Data;diabetes management;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;Diuretics;Dyslipidemias;epidemiology study;Erythrocytes;Event;experience;Failure;fasting plasma glucose;Genetic;genetic association;genetic variant;Genetic Variation;genome wide association study;Genotype;Glucose;Glucosephosphate Dehydrogenase Deficiency;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;High Density Lipoprotein Cholesterol;high risk;Hypertension;IGF2R gene;improved;indexing;Individual;individual response;individualized medicine;International;LDL Cholesterol Lipoproteins;life span;Link;Manuscripts;MAS1 gene;Measurement;medical schools;Meta-Analysis;mortality;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Organ;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Phenotype;Population;Regimen;Research Personnel;Resistant Hypertension;response;Risk;Risk Reduction;sex;Therapeutic;Trans-Omics for Precision Medicine;Triglycerides;Universities;Variant;Virginia;Work

PROJECT_TITLE: Statistical Genetics of Outcomes and Drug Response in Patients with Type 2 Diabetes.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: WHEELER, MATTHEW  (contact)

PROJECT_TERMS: 2019-nCoV;Bayesian Method;Biological;Biological Assay;complex data;Computational algorithm;COVID-19;Data;Data Set;Data Sources;data streams;Development;Genes;Goals;high throughput analysis;human coronavirus;Journals;large datasets;Manuscripts;method development;Methodology;Mission;National Institute of Environmental Health Sciences;neuroimaging;Noise;novel;novel coronavirus;Output;programs;Research;research and development;Research Personnel;response;SARS coronavirus;Science;Scientist;Severe Acute Respiratory Syndrome;Signal Transduction;Statistical Models;Techniques

PROJECT_TITLE: Non-parametric Bayesian Method Development


PROJECT_TERMS: Bayesian Analysis;Benchmarking;Biological Assay;Biological Process;Chemicals;Complex;Data;data streams;Dose;Estimation Techniques;gene network;Genes;Goals;Literature;method development;Methodology;Mission;Modeling;National Toxicology Program;novel;Research;response;Techniques;tool;Toxic effect;Toxicogenomics;Toxicology

PROJECT_TITLE: Dose-response Methods Development for High Throughput, Nontraditional, and Standard Bioassays


NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Dietary Supplements;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Natural Products;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research

PI_NAMEs: SHI, MIN  (contact)

PROJECT_TERMS: Affect;Age;Area;Autoimmune Diseases;Biological;Blood Glucose;Brain;Budgets;Calcinosis;Carotenoids;Clinical Trials;clinically relevant;Cohort Studies;Collaborations;Complications of Diabetes Mellitus;Data;Data Analyses;Dermatomyositis;design;Diabetes Mellitus;Diagnosis;Early Diagnosis;Early Intervention;Environmental Health;epidemiology study;Equity;Event;experimental study;Extramural Activities;fatty acid supplementation;fetal;Genetic;Genetic Programming;Genetic study;genome wide association study;Goals;Health;Inflammatory;Lateral;Leadership;Life;London;Lutein;Manuscripts;method development;Methods;Mus;Myositis;Neurologic;Omega-3 Fatty Acids;Paper;Parents;Patients;Phenotype;Positioning Attribute;pulmonary function;racial disparity;Research;Research Design;Research Personnel;Research Project Grants;Rheumatism;Sampling;sex;Sex Differences;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Statistical Methods;Supination;tool;trend;Twin Multiple Birth;United States National Institutes of Health;Wages;Work;Writing;zeaxanthin

PROJECT_TITLE: Statistical methods in collaborative research


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WALKER, VICKIE  (contact)

PROJECT_TERMS: Address;Area;Automation;Bibliography;biomarker identification;Chemicals;cluster computing;Communication;Communities;cost;cyber infrastructure;Data;data dictionary;data infrastructure;data integration;data management;data mining;data pipeline;data repository;data resource;Data Set;data sharing;data visualization;Databases;Development;diverse data;Dose;Ensure;Environment;environmental chemical;Environmental Health;evidence base;FAIR principles;Generations;GENIE;Genomics;High Performance Computing;Ice;improved;In Vitro;in vivo;Informatics;informatics infrastructure;International;interoperability;Investments;Knowledge;Knowledge Management;Language;large language model;Libraries;meetings;Methods;middleware;Modeling;Molecular;Names;National Institute of Environmental Health Sciences;novel strategies;online resource;Ontology;Pathology;Phenotype;Practice Management;Process;programs;Property;Provider;Publications;query tools;Research;Resources;response;skill acquisition;software development;software systems;Source;Standardization;Strategic Planning;structured data;synthetic data;System;Terminology;Tissues;tool;Toxicology;Training;TRUST principles;United States National Institutes of Health;Update;web site;Work

PROJECT_TITLE: Scientific Cyberinfrastructure Research Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PI_NAMEs: MONTIEL ISHINO, FRANCISCO ALEJANDRO (contact)

PROJECT_TERMS: Accounting;Acculturation;Address;Adult;Affect;Anger;Anxiety;Area;Atherosclerosis;Attenuated;Attitude;Award;Behavior;Bhutanese;biobehavior;Biological;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Categories;Chronic Disease;cohesion;Collection;Communities;community health study;community organizations;comorbidity;Complex;COVID-19 pandemic;Crime;Cross-Sectional Studies;Data;Data Collection;depressive symptoms;design;dietary;Discrimination;Disease;Disparity;Disparity population;Distal;Distress;Doctor of Philosophy;Education;effective intervention;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;evidence base;experience;Feasibility Studies;Foundations;Friends;Funding;Future;Goals;Health;Health behavior;health care availability;health care service;health determinants;Health Disparities Research;health disparity;health equity;health outcome disparity;high risk;Hispanic Women;Hypertension;Immigrant;Incidence;Inequity;innovation;interest;Intervention;intimate partner violence;Language;Linguistics;Literature;Low income;Malignant Neoplasms;marginalization;Measures;Mediator;medically underserved;Mental Health;Methodology;Methods;minimally invasive;minority health;minority health disparity;model generalizability;Modeling;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Ohio;Outcome;Participant;Pathway interactions;Patient Self-Report;Phase;physical conditioning;Population;Populations at Risk;Prevalence;Process;Prospective cohort;Proxy;Publishing;recruit;Refugees;Religiosity;Reporting;resilience;Risk;Risk Factors;Role;Safety;sample collection;Sampling;Sister;Sleep;sleep abnormalities;Sleep disturbances;Sleeplessness;social;social cohesion;Social Environment;social factors;Social support;socioenvironmental factor;South Asian;Spirituality;Stress;Study Section;substance use;Symptoms;syndemic;Syndrome;telehealth;trait;Transportation;United States National Institutes of Health

PROJECT_TITLE: SocioEnvironmental & Ecological Disparities Group: Identifying the Health Impacts of Dynamic Inequities


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Affect;Asthma;Chromosome Mapping;chronic respiratory disease;cohort;Complex;Data;data sharing;Development;Diabetes Mellitus;Disease;Environment;Epigenetic Process;ethnic difference;Ethnic Population;Etiology;Exposure to;Fishes;gene environment interaction;Genes;Genetic;Genetic study;genetic variant;genome sequencing;Goals;Health;Lead;Life;lifestyle factors;Link;Maps;method development;Methodology;Methods;Migraine;Modeling;North Carolina;Occupational Exposure;Participant;personalized medicine;pollutant;pregnancy hypertension;Publishing;Questionnaires;racial difference;racial population;Recording of previous events;Research;Research Personnel;Resources;Science;Surveys;tool;Update;Variant;Visualization software;web-based tool;Weight;whole genome;Work

PROJECT_TITLE: The Personalized Environment and Genes Study


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: DIAZ-SANTANA, MARY  (contact)

PROJECT_TERMS: Algorithms;Breast;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;Breast Cancer Treatment;cancer health disparity;cancer survival;clinical practice;Data;Death Rate;Discrimination;Disease;Early Diagnosis;Early treatment;Goals;Hispanic;Hispanic Populations;Hispanic Women;improved;Incidence;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;mortality;Ovarian;Performance;Play;polygenic risk score;Population;Poverty;predictive tools;Puerto Rican;Puerto Rico;Reporting;Risk;Risk Estimate;risk prediction;risk prediction model;Role;Sister;Social Environment;sociodemographics;socioeconomic disparity;Socioeconomic Factors;Subgroup;tool;United States;Woman;Women's mortality;Work

PROJECT_TITLE: Breast Cancer Risk prediction for Hispanic women.


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: PACKENHAM, JOAN  (contact)

PROJECT_TERMS: Acute;adverse pregnancy outcome;Age;Agreement;Area;Awareness;Biological Assay;biomarker selection;Blood;cardiovascular health;Chronic;Chronic Disease;Clinical;cohort;Collaborations;Collection;Communities;community intervention;COVID-19 disparity;COVID-19 impact;COVID-19 intervention;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;design;Dimensions;Disease Progression;Disparity;disparity reduction;Dust;Enrollment;Equity;experience;Family;Follow-Up Studies;Health;health equity;high risk population;Incidence;Individual;Literature;long term consequences of COVID-19;Longterm Follow-up;maternal morbidity;Maternal Mortality;Minority Women;Outcome;pandemic impact;Parents;Participant;Population;population based;pre-pandemic;Process;promote resilience;Psyche structure;public health intervention;Recovery;recruit;reproductive;Research;research study;resilience;Risk Factors;Saliva;Sampling;SARS-CoV-2 infection;Severities;Socioeconomic Status;Structure of nail of toe;Subgroup;Surveys;syndemic;Treatment outcome;Urine;Woman;Women's Health;wristband;young woman

PROJECT_TITLE: Women's Health Awareness Community Resiliency, Environmental Action and Collaborations for Health Equity - (WHA REACH Equity Study)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

PI_NAMEs: GOLDBERG, MANDY  (contact)

PROJECT_TERMS: Adolescent;Adult;Age;Age Months;Automobile Driving;Biological;Biological Markers;Biological Monitoring;Birth;Black race;Body mass index;Body Size;Breast;Breast Cancer Risk Factor;cancer epidemiology;carcinogenesis;Child;Childhood;cohort;Cohort Studies;Collaborations;consumer product;critical period;Data;Development;early thelarche;Endocrine Disruptors;Enrollment;environmental chemical;Environmental Exposure;Exposure to;feeding;follow-up;girls;Goals;Gonadal Steroid Hormones;Growth;Growth and Development function;Hair;Health;Hispanic;Hormonal;Hormones;Incidence;infancy;Infant;Joints;Latina;Life;Life Cycle Stages;Link;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Nail plate;National Institute of Environmental Health Sciences;Parabens;Participant;Pathway interactions;Pattern;personal care products;Phenols;population based;Predisposition;Pregnancy;programs;pubertal timing;Puberty;puberty transition;Publications;racial difference;Reporting;reproductive development;Research;Risk;Risk Factors;Self Care;Sister;Source;Toddler;urinary;Uterine Cancer;White Women;Women's Health;Work

PROJECT_TITLE: Puberty and Cancer Epidemiology


NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PROJECT_TERMS: Address;Ancillary Study;Area;Biochemical;Biological Assay;Cardiovascular Diseases;cohort;Cohort Studies;Contracts;Data;data acquisition;data integration;Data Set;Diabetes Mellitus;Electronic Health Record;Environment;Environmental Exposure;Environmental Risk Factor;gene environment interaction;Genes;genomic data;Genomics;Health;health data;Human;Link;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;Participant;Recording of previous events;Research;Resources;social factors;social health determinants;success

PROJECT_TITLE: Exposomics Ancillary Study in All of Us


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Polycystic Ovary Syndrome (PCOS);Women's Health Research

PI_NAMEs: SHEKHAR, SKAND  (contact)

PROJECT_TERMS: Adult;Child;Clinical assessments;clinical care;Clinical Data;clinical phenotype;Data;Endocrine;Endocrine System Diseases;Enrollment;Environment;Environmental Exposure;Exposure to;Functional disorder;Human;Hyperandrogenism;Hypogonadism;Inherited;insight;interest;Life Style;Participant;Patients;Polycystic Ovary Syndrome;prospective;Protocols documentation;recruit;reproductive;reproductive function;reproductive neuroendocrinology;reproductive system disorder;response;Secondary to;Study Subject;Touch sensation;treatment response

PROJECT_TITLE: Observation of Environment and Reproductive-Endocrine Effects


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CHOI, KELVIN  (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Advertising;Age;aged;Agreement;Alcohol consumption;Area;Asthma;Attitude;Awareness;Behavior;Behavioral;behavioral health;Behavioral Research;Behavioral Risk Factor Surveillance System;Black race;Body mass index;California;Cannabis;Cessation of life;Characteristics;Child;Cigar;Cigarette;cigarette smoking;cigarillos;Classification;cohort;Complex;Cotinine;Data;Databases;demographics;Disability status;discount;discounting;Disparity;Disparity population;e-cigarette cessation;Economics;Education;Educational Status;Electronic cigarette;electronic cigarette use;environmental tobacco smoke;environmental tobacco smoke exposure;Epidemiology;Ethnic Origin;Evaluation;Expenditure;General Population;Goals;Health;health communication;health disparity;Health Personnel;Health Status;High Prevalence;High School Student;Hispanic;Home;Hour;Household;Income;Individual;Industry;insight;interest;Intervention;Knowledge;Light;Link;marijuana use;Market Research;Marketing;Mediating;Mental Health;Modeling;mortality;National Health and Nutrition Examination Survey;Nicotine;novel;Outcome;Patient Self-Report;Pattern;pediatric health outcomes;Persons;Physical activity;Policy Maker;Population;Population Assessment of Tobacco and Health;population based;population health;Predisposition;Prevalence;Price;protective factors;Public Health;Public Health Education;public policy on tobacco;Race;Reaction;Recommendation;Reduce health disparities;reduce tobacco use;Reporting;Research;response;return to use;Risk;Risk Factors;Sampling;secondary analysis;Serum;Services;sex;Sleep;Sleep Deprivation;Sleep disturbances;sleep quality;Smoke;smokeless tobacco use;Smoker;Smoking;smoking initiation;smoking prevalence;Smoking Status;social;social determinants;social health determinants;social influence;Social Marketing;socioeconomics;substance use;Surgeon;Surveys;Target Populations;Taxes;Testing;thirdhand smoke;Tobacco;tobacco advertising;tobacco control;tobacco exposure;Tobacco Industry;tobacco products;tobacco smoke exposure;Tobacco use;tobacco user;Vision;Work;young adult;Youth

PROJECT_TITLE: Understanding and reducing health disparities through social and behavioral research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

PI_NAMEs: ZENK, SHANNON  (contact)

PROJECT_TERMS: Affect;authority;Baltimore;Behavior;Bibliography;built environment;career;climate change;Collaborations;Communities;Complex;Data Collection;data collection methodology;data quality;design;Development;energy balance;Ensure;Environment;ethnic disparity;Extramural Activities;falls;farmer;Fruit;Geographic Locations;Growth and Development function;Health;Health behavior and outcomes;Health Care Costs;health data;health disparity;health disparity populations;Health equity research;Hispanic Community Health Study/Study of Latinos;Housing;Human Resources;innovation;Institutional Review Boards;Intervention;Journals;laboratory development;Manuscripts;Measures;medical schools;member;Mentors;Metabolic;Methods;minority health;National Institute on Minority Health and Health Disparities;Neighborhoods;Oral;Paper;Pathway interactions;Physical environment;Policies;Postbaccalaureate;Postdoctoral Fellow;posters;Preparation;programs;Publications;Publishing;PubMed;racial disparity;Reduce health disparities;Research;Schools;Science;secondary analysis;Services;Social Environment;Surveys;symposium;Temperature;Testing;Time;Training;United States National Institutes of Health;Update;Urban Health;volunteer;wearable data;Woman;Work

PROJECT_TITLE: Neighborhoods and Health Lab


ACTIVITY: ZIC

ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

PI_NAMEs: ABSHARI, MEHRNOOSH  (contact)

PROJECT_TERMS: Blood Platelets;Cell Separation;cell type;Cells;craniofacial;Cytometry;Dental;digital;Disease;DNA sequencing;Flow Cytometry;Goals;Histology;Hour;Image;Image Cytometry;Imaging Device;monocyte;National Institute of Dental and Craniofacial Research;operation;Oral;Peripheral Blood Mononuclear Cell;Reaction;Research;Research Personnel;Research Support;Resources;Sampling;Scanning;Services;Sorting;Stains;Students;T-Lymphocyte;Technology;tissue processing;Tissues;Training

PROJECT_TITLE: NIDCR DIR Scientific Cores (Combined Technical Research Core)


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Obesity

PI_NAMEs: TRAVLOS, GREGORY  (contact)

PROJECT_TERMS: Anatomy;Archives;Artificial Intelligence;Autopsy;Biological Assay;carcinogenesis;Cardiovascular Diseases;Clinical;Clinical Chemistry;Clinical Pathology;Collaborations;Communities;Consultations;Data;Development;dietary restriction;digital imaging;Disease;Electron Microscopy;Embryo;Equipment and supply inventories;Gene Expression;Gene Expression Regulation;Goals;Hematology;Histology;Image;Image Analysis;Immune;Immunoassay;Immunohistochemistry;improved;Inflammatory;Infrastructure;Kidney Diseases;Knowledge;Laboratories;Laboratory Research;Lasers;Lesion;Mediating;Medical;Methods;Microdissection;Mission;Modernization;Mus;National Institute of Environmental Health Sciences;neoplastic;new technology;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pathogenesis;Pathologist;Pathology;Phenotype;Procedures;Process;programs;Protocols documentation;Public Health;Research;Research Personnel;Respiratory Disease;Retrospective Studies;sample collection;Science;Services;Skeletal Development;System;Technical Expertise;Techniques;Testing;Toxicology;Work

PROJECT_TITLE: Pathology Services Supporting the Division Translational Toxicology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Age;age difference;Area;Asian;Behavioral;Blood Pressure;burden of illness;cancer epidemiology;cancer genetics;Cirrhosis;Clinical;clinical center;Clinical Research;clinical translation;Collaborations;Collection;Communities;computer framework;Contractor;Contracts;County;Data;data visualization;Databases;Descriptive Epidemiology;Dimensions;disability;disability-adjusted life years;Disease;Disease stratification;disparities in morbidity;Disparity;Doctor of Philosophy;Education;Environmental Exposure;Epidemiologist;Epidemiology;Equity;ethnic disparity;ethnic minority population;Ethnic Origin;Evaluation;Exposure to;Faculty;falls;fasting plasma glucose;Gender;gender minority group;genome sciences;geographic difference;Health;health disparity;health equity;Health Status Indicators;high body mass index;high reward;high risk;Human Resources;Immunologic Epidemiology;improved;Incidence;Individual;Infection;Interdisciplinary Study;Interest Group;intersectionality;Intervention;Knowledge;Laboratories;Leadership;Life;Life Expectancy;Location;Malignant neoplasm of liver;Measures;medical schools;Methodology;Minnesota;Minority Groups;Minority Health Research;Mission;Morbidity - disease rate;mortality;multi-racial;multiple datasets;National Institute of Dental and Craniofacial Research;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Neighborhoods;Obesity;Outcome;Patient Participation;Pattern;Personal Satisfaction;Population;Population Attributable Risks;Positioning Attribute;Premature Mortality;Prevalence;Procedures;Professional counselor;professor;Public Health;Publishing;Race;racial disparity;racial minority population;racial population;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Scientific Advances and Accomplishments;Scientist;Series;sex;Sexual and Gender Minorities;social;social disparities;social health determinants;Socioeconomic Status;Sum;tenure track;Translational Research;Underserved Population;underserved rural area;United States;United States National Institutes of Health;Universities;Update;Vulnerable Populations;Work;working group;years lived with disability;years of life lost

PROJECT_TITLE: Office of the Scientific Director


ACTIVITY: ZIE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: American Indian Population;anti-cancer research;Award;Biomedical Research;career;Characteristics;Communities;Dedications;diversity and inclusion;Division of Cancer Epidemiology and Genetics;Doctor of Philosophy;Educational workshop;Emergency department visit;Endocrinologist;Endocrinology;Equity;equity, diversity, and inclusion;ethnic difference;Ethnic equity;Exposure to;Funding;Goals;Growth;Health Disparities Research;health disparity;innovation;Internal Medicine;Interview;Intramural Research;Intramural Research Program;Lead;Leadership;Manufactured basketball;Manuscripts;Medical;Medical Research;meetings;member;Mentors;minority health;minority health disparity;Minority Health Research;National Institute of Dental and Craniofacial Research;National Institute of Neurological Disorders and Stroke;National Institute on Minority Health and Health Disparities;next generation;Oral health;Participant;Patient Self-Report;Physicians;Post-Acute Sequelae of SARS-CoV-2 Infection;Postbaccalaureate;Postdoctoral Fellow;posters;Principal Investigator;programs;Quality of life;racial difference;Racial Equity;Research;Research Personnel;Research Support;Research Training;Resource Allocation;Scholars Program;Science;Scientist;Services;Site;Spottings;Statistical Data Interpretation;Structural Racism;summer internship;symposium;Symptoms;tenure track;Traineeship;Training;Training Programs;tribal community;Underrepresented Populations;United States National Institutes of Health;Woman;Work;working group

PROJECT_TITLE: Intramural Diversity in Medical Research Initiatives


ACTIVITY: ZII

PROJECT_TERMS: Behavioral Sciences;Clinical;Clinical Research;Community Health;Dryness;Epidemiology;epidemiology study;Floor;Future;Genetic;Goals;Health Disparities Research;health disparity;Health Sciences;high risk;Intramural Research;Intramural Research Program;minority health;minority health disparity;Minority Health Research;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;Open Reading Frames;population health;Privatization;programs;Research;Research Personnel;Secure;Social Sciences;tenure track;United States National Institutes of Health;Work

PROJECT_TITLE: NIMHD Space Activation


ACTIVITY: ZIJ

NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: African;African ancestry;American;Asian ancestry;Asian population;Black Populations;Certification;Clinic;clinical center;clinical practice;Clinical Research;clinical training;Data;design;diabetes educator;diabetes management;Diabetes Mellitus;Diagnosis;Diagnostic;Doctor of Philosophy;efficacy evaluation;Endocrinology;Environment;Ethnic Origin;European;experience;Fellowship;Fellowship Program;Funding;Genocides;global health;Glucose;Health;health equity;Hour;Immigrant;Individual;innovation;International;Journals;Learning;low income country;Medical;meetings;Meta-Analysis;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Minority Health and Health Disparities;New York;Obesity;OGTT;Physiological;programs;Publications;Publishing;Recommendation;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;Running;Rwanda;Scholarship;Screening procedure;Training;Travel;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Rwandan Research Fellowship


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PROJECT_TERMS: adaptive immune response;Address;Adherence;Adrenal Glands;African American;African American Women;Age;age related;Aging;aging biomarker;Alcohol consumption;alcohol craving;Alkaline Single-Cell Gel Electrophoresis Assay;Alleles;Allergens;anti-cancer research;Antibodies;anxiety symptoms;Area;Award;Behavioral Sciences;biological age;Biological Aging;Biological Assay;Black Populations;Black race;Breast Cancer survivor;Cardiac;Cardiovascular Diseases;Catecholamines;Cell Physiology;Cells;Chemicals;Chronic;Chronic stress;Clinical;cognitive interview;cohort;Cohort Studies;Communities;Community Health;cue reactivity;cytokine;Data;Data Sources;Dedications;depressive symptoms;design;Development;dietary;Discrimination;Disparity;DNA;DNA Damage;DNA Repair;Doctor of Medicine;Doctor of Philosophy;environmental chemical;Epidemiology;epigenomics;ethnic discrimination;Ethnic Origin;Ethnic Population;evidence base;exercise physiologist;Exhibits;experience;Feedback;Female Breast Carcinoma;Frequencies;functional decline;Funding;Future;Genus Hippocampus;Goals;good diet;Haplogroup;Health;Health Disparities Research;health disparity;health inequalities;Health Personnel;Heart;Heart failure;Helicobacter Infections;high risk;Human Biology;Hypertension;Hypothalamic structure;Immigrant;immunoregulation;In Vitro;Individual;Inflammation;Inflammatory;inflammatory marker;Innate Immune Response;innovation;interest;Intervention;Intramural Research Program;Investigation;Investments;Joints;Latino;Latino Population;Legal Status;Life Cycle Stages;Lipopolysaccharide Biosynthesis Pathway;Malignant Breast Neoplasm;Measures;medically underserved;member;Mentors;Methods;Minority Groups;minority health;minority health disparity;Mitochondria;Mitochondrial DNA;Modeling;Mood Disorders;mortality;Multi-Ethnic Study of Atherosclerosis;multiplex assay;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;National Institute on Aging;National Institute on Minority Health and Health Disparities;Natural Killer Cells;Nuclear;obesity risk;Oncologist;Oxidative Stress;Participant;Patient Self-Report;perceived discrimination;Physical activity;physical conditioning;Pituitary Gland;population health;Postdoctoral Fellow;pre-clinical;preference;premature;Principal Investigator;Proxy;psychologic;psychological distress;psychological outcomes;Psychosocial Stress;Race;racial discrimination;racial minority population;Recommendation;Recording of previous events;Recurrence;repaired;Research;Research Personnel;Research Project Grants;response;Review Committee;Risk;Risk Factors;Role;Sampling;Scientist;Serum;Sister;Smoke;social;Social Sciences;Stress;stressor;Structure;substance use;Surveys;Sympathetic Nervous System;Symptoms;Testing;theories;Tobacco;Tobacco use;Toxic Environmental Substances;Toxicant exposure;Training;United States;United States National Institutes of Health;vapor;vigilance;Visit;Work

PROJECT_TITLE: William G. Coleman Award


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Cardiovascular;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Scleroderma;Sleep Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;admixture mapping;Adult;African;African American;African American population;African ancestry;Age;age related decline;Air Pollution;Amino Acids;Appointment;Area;Asian ancestry;Athletic;Autoimmune;Award;Behavior;Behavior Therapy;Biological Process;Black American;Black Populations;black women;Calcinosis;cancer health disparity;cancer prevention;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Catabolism;Cell Cycle Regulation;Censuses;Childhood;Chronic stress;Circulation;climate change;Clinical Investigator;Clinical Management;clinical practice;cohort;Cohort Studies;Collaborations;college;Coronavirus;Data;Data Science;Decidua Basalis;Dementia;Development;Diabetes Mellitus;Diagnosis;digital health;Disabled Persons;Disease;Disease Outcome;Disparity;diversity and inclusion;Early Intervention;Environment;environmental chemical;epigenome;ethnic discrimination;Ethnic Origin;Ethnic Population;European;Event;experience;Exposure to;Female;fetal;Fetal Growth;Floods;Follow-Up Studies;food insecurity;frailty;Funding;Gases;Gene Expression;Genes;Genetic;genetic analysis;genetic testing;Genome;Glucose;Goals;Growth;Health;Health behavior;health determinants;Health Disparities Research;health disparity;health equity;Health Technology;healthy aging;high risk;higher education;Hispanic Populations;Home;Hypertension;improved;Individual;Inflammation;inorganic phosphate;insight;International;Intervention;Intramural Research;Journals;killings;Knowledge;Laboratories;late life;Life;life span;Link;loss of function;male;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Manuscripts;Maps;marijuana use;Mentors;Meta-Analysis;Metabolism;Methods;minority health;minority health disparity;Modeling;Molecular;Molecular Epidemiology;Musculoskeletal Physiology;National Heart, Lung, and Blood Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;Native Hawaiian;neighborhood disadvantage;Neighborhoods;NOTCH4 gene;novel;Occupations;Outcome;Pacific Islander;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Physiological;Placenta;Population;Postdoctoral Fellow;Predisposition;Pregnant Women;programs;Publications;Race;racial discrimination;racial minority population;racial population;Recommendation;Research;Research Personnel;Research Training;Resource-limited setting;Resources;Review Committee;Risk;Risk Factors;Schedule;Scleroderma;sex;sex variable;Skin;Sleep;Sleep disturbances;sleep health;sleep quality;Sleeplessness;social;social vulnerability;South Carolina;spatiotemporal;Strategic Planning;Susceptibility Gene;Systemic Scleroderma;T cell receptor repertoire sequencing;tenure track;therapy development;Tissue-Specific Gene Expression;Toxicokinetics;Toxicology;transcriptome;Translational Research;Travel;Tumor Biology;Tumor Promotion;United States;United States National Institutes of Health;Variant;Vascular Diseases;volatile organic compound;Work;young adult

PROJECT_TITLE: NIMHD Adjunct Investigator Program


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative The proposed study will test the hypothesis that reduced APOE expression in the brain contributes to neurobehavioral deficits in FASD and that treatment with APOE mimetics alleviates these deficits. This study will not only uncover novel APOE-mediated mechanisms in FASD, but will also test the potential for a novel intervention approach to FASD.

PI_NAMEs: HASHIMOTO-TORII, KAZUE ;TORII, MASAAKI  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Alcohols;Apolipoprotein E;Biological Availability;Brain;Brain region;Calcium-Activated Potassium Channel;calmodulin-dependent protein kinase II;cell type;Cells;Cerebral cortex;Child;Chromatin;clinically relevant;Cognitive;Cognitive deficits;CREB1 gene;Data;Development;Dose;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy testing;Enhancers;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional disorder;Funding;Gene Expression;Genes;genome-wide;Goals;Human;Immunohistochemistry;improved;insight;Intervention;Intraperitoneal Injections;Investigation;Lead;Learning;Longitudinal Studies;Mediating;Mediator;mimetics;Modeling;Molecular;Motor Cortex;motor learning;multiple omics;Mus;neurobehavior;neurobehavioral;Neuronal Plasticity;Neurons;Neurosciences;novel;novel therapeutics;offspring;Organ;Pathway interactions;peptidomimetics;pharmacologic;Phosphorylation;Plasma;Play;postnatal;Potassium Channel;restoration;Risk Factors;Role;Route;Signal Transduction;Single Nucleotide Polymorphism;Specificity;Structure;symptom treatment;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Translating;Treatment Efficacy;Western Blotting

PROJECT_TITLE: Mechanisms and treatments of learning deficits in Fetal Alcohol Spectrum Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

ORG_STATE: MD

PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: Antigens;Area;Award;Clinical Trials;Contractor;Contracts;Databases;Development;Documentation;efficacy study;Equipment;Equipment and supply inventories;HIV vaccine;HIV-1;Human;Human Resources;immunogenicity;In Vitro;Information Systems;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;meetings;National Institute of Allergy and Infectious Disease;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;Reagent;Reporting;research clinical testing;Secure;Specimen;System;Temperature;Testing;Time;timeline;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: NIAID Preclinical Development Support: Essential Core Activities


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: VEINNA

ORG_COUNTRY: AUSTRIA

ORG_FIPS: AU

ORG_NAME: EVELIQURE BIOTECHNOLOGIES, GMBH

PI_NAMEs: MALINOWSKI, FRANK  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;Clinical;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Escherichia coli;Formulation;immunogenicity;Individual;manufacture;response;Safety;stability testing;Toxicology;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccine Candidates for Antibiotic Resistant Bacteria


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Clinical trials have become overly complex and expensive, resulting in major gaps in the availability of and knowledge about medical products. The Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke University, and involving all interested parties across the clinical trials ecosystem, develops and drives the adoption of recommendations and resources to improve the quality and efficiency of clinical trials. Through the support of this cooperative agreement, Duke will host and support CTTI's work to shape better the clinical trials of the future.

PI_NAMEs: ALEXANDER, JOHN H (contact)

PROGRAM_OFFICER_NAME: MILLER, KRISTEN

PROJECT_TITLE: Increasing the Quality and Efficiency of Clinical Trials (U18)


ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: RFA-FD-22-021 AFDO’s System for Agriculture, Food, Health, E-Inspections and Registration (SAFHER): Project Narrative The Association of Food and Drug Officials’ (AFDO) efforts under this cooperative agreement are intended to support the planning, development, implementation, operation, and maintenance of data management system to be utilized by State, Local, Tribal, and Territorial (SLTT) partners in both human and animal food programs. AFDO will build on an already established user community of stakeholders to enhance FDA’s ORA Data Exchange capabilities by utilizing software development methodologies (i.e. Agile) to ensure a long-term sustainable data management system that is easy to use and maintain by state regulatory partners during and after this cooperative agreement. Through effective governance, vendor procurement, and resource management, this project will deliver a national regulatory data repository that will work towards achieving a national Integrated Food Safety System (IFSS) while promoting One Health and supporting domestic mutual reliance initiatives to protect the food supply and advance public health.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: LAC, ANH

PROJECT_TITLE: System for Agriculture, Food, Health, E-inspection, and Registration (SAFHER)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: KANEKIYO, MASARU  (contact)

PROJECT_TERMS: Adjuvant;Adult;Animal Model;Animals;Antibody Response;Antigens;Biological Assay;combat;design;Disease;Effectiveness;Enrollment;Ferrets;Ferritin;Goals;Hemagglutinin;human subject;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunologics;improved;Individual;Infection;Influenza;Influenza A virus;influenza virus strain;influenza virus vaccine;influenzavirus;Licensing;manufacture;Membrane Glycoproteins;Messenger RNA;Methodology;mosaic;Mus;Mutation;nanoparticle;Neuraminidase;neutralizing antibody;new pandemic;next generation;nonhuman primate;Nucleic Acid Vaccines;pandemic disease;pandemic influenza;pandemic potential;pandemic virus;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;pre-pandemic;preclinical study;Production;programs;Public Health;Research;response;Risk Reduction;safety assessment;seasonal influenza;self assembly;stem;Structure;Testing;Time;tool;universal influenza vaccine;Vaccinated;vaccination strategy;vaccine candidate;vaccine development;vaccine immunogenicity;vaccine platform;Vaccine Production;Vaccine Research;Vaccines;Virus;Work

PROJECT_TITLE: Influenza Vaccine Research and Development


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: KOUP, RICHARD A (contact)

PROJECT_TERMS: Anti-Retroviral Agents;Biological Models;CD4 Positive T Lymphocytes;HIV;Human;Immune response;in vivo;Individual;nonhuman primate;Patients;Persons;simian human immunodeficiency virus;SIV;T-Lymphocyte;Vaccines;Virus Replication

PROJECT_TITLE: HIV/SIV Replication In Vivo


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;B-Lymphocytes;Biology;CD4 Positive T Lymphocytes;Cell Communication;Cells;Characteristics;Chronic;Complex;Defect;Development;Goals;Helper-Inducer T-Lymphocyte;HIV;Human;Immunoglobulins;Infection;lymph nodes;Molecular;Monkeys;Mus;neutralizing antibody;nonhuman primate;Pathogenesis;Phenotype;Population;Predisposition;Process;programs;Proteins;recruit;response;Signal Transduction;SIV;spatiotemporal;Structure of germinal center of lymph node;T-Lymphocyte;Vaccination;vaccination protocol;Virus

PROJECT_TITLE: Tfh and B cells in HIV/SIV pathogenesis and vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ZHOU, TONGQING  (contact)

PROJECT_TERMS: 2019-nCoV;Antibodies;B-Lymphocytes;Binding Sites;Cell Ontogeny;Clinical;clinical application;Collaborations;Epitopes;HIV;HIV Infections;HIV-1;human pathogen;Immune system;improved;Infection prevention;influenzavirus;insight;Lassa virus;manufacture;neutralizing antibody;pathogen;Pathway interactions;Prevention;Structure;Therapeutic Agents;Vaccine Design;vaccine-induced antibodies;Vaccines;Work

PROJECT_TITLE: Antibody Neutralization Mechanisms


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;Alpha Virus;Antibodies;Bypass;Cryoelectron Microscopy;design;Development;Disease;Electrons;Glycoproteins;glycosylation;Goals;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;human pathogen;Immune Evasion;Immune response;Immune system;Individual;Infection;Influenza A virus;interest;Investigation;Lassa virus;Location;Malaria;Maps;Minority;Molecular Conformation;molecular dynamics;neutralizing antibody;pathogen;Polysaccharides;Proteins;Publishing;Respiratory syncytial virus;response;single-molecule FRET;Structure;Tomogram;Vaccines;Variant;Virion;Virus;X-Ray Crystallography

PROJECT_TITLE: Mechanisms Of Humoral Evasion


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: 2019-nCoV;Antibodies;Antigens;B-Lymphocytes;Binding Sites;Carrier Proteins;Cell Ontogeny;Clinical Trials;Coupled;Cryoelectron Microscopy;design;Developmental Process;disabled;Epitopes;Exposure to;General Population;Glycoproteins;HIV-1;HIV-1 vaccine;Homologous Protein;Hospitalized Child;human pathogen;immune activator;Immune response;Immunization;immunogenic;immunogenicity;improved;influenzavirus;insight;Knowledge;Lassa virus;Malaria;manufacture;Medicine;N-terminal;nanoparticle;neutralizing antibody;NMR Spectroscopy;Norovirus;pathogen;Peptides;Phase;Process;protein data bank;Proteins;Reagent;Respiratory syncytial virus;response;scaffold;Scaffolding Protein;self assembly;Structure;Surface;Technology;tool;Transplantation;Vaccine Design;vaccine evaluation;X-Ray Crystallography

PROJECT_TITLE: Design Of Immunogens


PI_NAMEs: DOUEK, DANIEL CESAR (contact)

PROJECT_TERMS: Affect;Africa;antiretroviral therapy;CD4 Positive T Lymphocytes;Cell Count;Cell Physiology;Cells;circulating biomarkers;Clinical;cohort;Communicable Diseases;Fibrin fragment D;HIV;HIV Infections;Human;Immune;Individual;Inflammation;inflammatory marker;Influenza;interest;Interleukin-6;Malaria;Malignant Neoplasms;Measures;Metabolic Marker;Metabolic Pathway;microbial;microbial products;Morbidity - disease rate;mortality;Outcome;Persons;Plasma;Sampling;systemic inflammatory response;Systems Biology;T cell reconstitution;T-Cell Activation;Thailand;transcriptome;Viral load measurement

PROJECT_TITLE: Inflammation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: adaptive immune response;antibody conjugate;Antibody Response;Antigen Receptors;antigen-specific T cells;Antigens;B-Lymphocytes;Cancer Model;Cavia;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;COVID-19;Custom;Evolution;Genomics;HIV;Immune;Immune response;Immunoglobulins;Immunologic Receptors;Infection;Influenza;Libraries;Macaca fascicularis;Macaca mulatta;Malignant Neoplasms;mouse model;Nature;next generation sequencing;pathogen;Proteomics;Protocols documentation;response;Sampling;T cell receptor repertoire sequencing;T-Lymphocyte;transcriptome;transcriptomics;Vaccination

PROJECT_TITLE: Immune Responses To HIV And Other Pathogens


PROJECT_TERMS: acute infection;Attention;CD4 Positive T Lymphocytes;Cells;cellular targeting;Disabling;Genome;Goals;HIV;Molecular;molecular targeted therapies;Persons;Proteins;Rest;Role;T-Cell Activation;therapy design;Work

PROJECT_TITLE: The HIV Reservoir


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DROPULIC, LESIA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Adenovirus Vector;Adenoviruses;Adjuvant;Adult;Adverse event;AIDS prevention;AIDS Vaccines;aluminum sulfate;Antibody Response;Antibody titer measurement;base;Binding;Clinic;Clinical;clinical center;clinical development;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Conjugate Vaccines;Data;design;Development;Devices;DNA;DNA Vaccines;dosage;Dose;efficacy study;Eligibility Determination;Enrollment;env Glycoproteins;Epidemic;Epitopes;follow-up;Futility;Future;gag Gene Products;Goals;HIV;HIV Infections;HIV prevention trial;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Immune;Immunize;immunogenicity;Injections;Innate Immune Response;Intramuscular;Investigation;Kinetics;manufacture;meetings;member;Methods;Multicenter Trials;Needles;nef Protein;neutralizing antibody;novel;novel strategies;open label;Pattern;Peptides;Phase;phase 1 study;Phase I Clinical Trials;Physicians;Placebos;plasmid DNA;Plasmids;pol Gene Products;Polyproteins;Polysaccharides;Preventive;Preventive vaccine;programs;prospective;Protocols documentation;prototype;Public Health;Publishing;Randomized;Recombinants;Recommendation;Regimen;Research Personnel;response;Route;Safety;Schedule;Secondary Immunization;Serotyping;Site;subcutaneous;Syringes;Therapeutic Studies;therapeutic vaccine;Vaccination;vaccination protocol;vaccine candidate;vaccine development;vaccine evaluation;vaccine evaluation center;Vaccine Research;vaccine trial;Vaccines;vector vaccine;Viral Load result;Work

PROJECT_TITLE: HIV Vaccine Studies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Services;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Binding Sites;Biological Assay;Biological Factors;Blood;Blood Component Removal;Body Fluids;Bone Marrow;Cells;clinical center;Clinical Trials;Communicable Diseases;Correlation Studies;Data;Development;Eligibility Determination;Emerging Communicable Diseases;Enrollment;experience;healthy volunteer;HIV;HIV envelope protein;Human;Image;Immune;immune function;Immune response;Immunity;Immunology procedure;influenza virus vaccine;Laboratories;Licensing;lymph nodes;Methods;Monoclonal Antibodies;Mononuclear;mosaic;Mucous Membrane;nanoparticle;next generation;novel;Pathogenesis;Plasma;Procedures;programs;Protocols documentation;radiological imaging;recruit;Research;research clinical testing;Research Personnel;research study;sample collection;Sampling;screening;screening program;Severity of illness;Skin;skin biopsy;Specimen;Swab;Tissues;transfusion medicine;United States National Institutes of Health;Vaccinated;Vaccination;vaccine candidate;Vaccine Clinical Trial;vaccine development;Vaccine Research;vaccine-induced antibodies;Vaccines;Validation;Venous blood sampling;Virus Diseases;volunteer;Work

PROJECT_TITLE: Sample Collection and General Screening Protocols


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Malaria;Malaria Vaccine;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;Adult;Age Years;Avian Influenza;biodefense;booster vaccine;Chikungunya virus;Clinic;Clinical Trials;Communicable Diseases;Data;Data Analyses;DNA;DNA Vaccines;Dose;Eastern Equine Encephalomyelitis;Ebola;Ebola Vaccines;Ebola virus;Emerging Communicable Diseases;emerging pathogen;Encephalitis Viruses;Enrollment;Evaluation;Ferritin;first-in-human;Generations;Genes;healthy volunteer;Human;Immunization Programs;immunogenicity;Infection;Influenza;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;Influenza Hemagglutinin;influenza virus vaccine;influenzavirus;Intramuscular;Intravenous;intravenous administration;Licensing;lumazine;lymph nodes;Malaria;malaria infection;Manuscripts;Marburgvirus;Messenger RNA;Mission;mosaic;nanoparticle;neutralizing antibody;Nipah;Nipah Virus;novel;open label;pandemic disease;Participant;particle;pathogen;Phase;phase 1 study;phase I trial;Plasmodium falciparum vaccine;programs;Publications;Publishing;Regimen;research clinical testing;Respiratory syncytial virus;Respiratory Syncytial Virus Vaccines;RNA vaccine;Route;Safety;safety assessment;Sampling;SARS coronavirus;Science;Scientist;seasonal influenza;Seasons;Severe Acute Respiratory Syndrome;Site;stem;Structure of germinal center of lymph node;Uganda;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;Vaccine Research;vaccine trial;Vaccines;Venezuelan Equine Encephalitis Virus;Virus-like particle;West Nile;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Biodefense and Emerging Infectious Disease and Influenza Vaccine Studies


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Patient Safety;Prevention;Vaccine Related

PROJECT_TERMS: adeno-associated viral vector;Adult;AIDS prevention;Anti-Retroviral Agents;Anti-viral Therapy;Antibodies;Antibody Binding Sites;antiretroviral therapy;Binding Sites;clinical center;Clinical Trials;Data Analyses;Development;Dose;Drug Kinetics;Enrollment;Epidemic;Evaluation;follow-up;healthy volunteer;HIV;HIV envelope protein;HIV-1;human monoclonal antibodies;Immunotherapeutic agent;Infection;Infusion procedures;insight;intravenous administration;Manuscripts;Monoclonal Antibodies;neutralizing monoclonal antibodies;next generation;novel strategies;Parents;Participant;Passive Immunity;Pharmaceutical Preparations;Phase;phase 1 study;pre-clinical;Preparation;programs;Public Health;Publications;Publishing;Recombinant adeno-associated virus (rAAV);Regimen;Research Project Grants;Safety;safety study;Scientist;Serum;side effect;Signal Transduction;subcutaneous;Subcutaneous Injections;Therapeutic;Time;United States National Institutes of Health;vaccine development;Vaccine Research;Viremia;volunteer

PROJECT_TITLE: HIV Monoclonal Antibody Studies


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Precision Medicine;Prevention;Sexually Transmitted Infections;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: acquired factor;Behavioral;cohort;Communicable Diseases;Data Set;Disease susceptibility;Epidemiology;Genetic;Genetic Polymorphism;genome wide association study;Genomics;Genotype;Geography;high risk;HIV;HIV Infections;HIV Vaccine Trials Network;Human Herpesvirus 2;Infection;infection rate;Male Circumcision;Nature;novel;Persons;precision medicine;Predisposition;Prevalence;Risk;Risk Factors;Sexually Transmitted Diseases;vaccine efficacy;Vaccines;Viral load measurement

PROJECT_TITLE: Host Genomic Factors in Infectious Disease Susceptibility


PROJECT_TERMS: Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Chronic;clinical development;Development;Disease Progression;exhaustion;Goals;HIV Infections;Immune;immune activation;Immune response;Infection;lymph nodes;Mediating;pathogen;Pathway interactions;T cell response;T-Lymphocyte;Time;Vaccination;vaccine development;Vaccines;Viral Vaccines;Virus Diseases

PROJECT_TITLE: Immune correlates of protection


PI_NAMEs: DORIA-ROSE, NICOLE  (contact)

PROJECT_TERMS: Adult;Animals;Antibodies;Antibody Response;antibody test;Antigens;B-Cell Development;B-Lymphocytes;Binding;Biochemical;Cells;Clinical Research;cross reactivity;deep sequencing;design;Development;Donor Selection;Engineering;Epitopes;glycoprotein structure;Glycoproteins;high throughput screening;HIV;HIV Antibodies;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;Immunize;Immunoglobulin G;improved;Individual;Infection;Macaca mulatta;Mammalian Cell;manufacturability;Methods;Modeling;Monoclonal Antibodies;Mutate;neutralizing antibody;next generation;next generation sequencing;nonhuman primate;novel;Patients;pediatric human immunodeficiency virus;Prevention;Reagent;Sampling;Serum;simian human immunodeficiency virus;SIV;Techniques;Testing;Time;Vaccinated;vaccine candidate;Vaccine Design;vaccine immunogenicity;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: HIV Neutralizing Antibodies: Isolation, characterization, and interaction with viral variants


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: SEDER, ROBERT A (contact)

PROJECT_TERMS: Adjuvant;Adult;Affinity;Animal Model;Antibodies;Antigens;Area;B-Lymphocytes;Blood;Characteristics;Child;circumsporozoite protein;Clinical Trials;Development;Drug Kinetics;Erythrocytes;Formulation;Goals;Human;Immunity;immunogenicity;Immunologic Adjuvants;improved;In Vitro;in vivo;in vivo Model;Infant;Infection;Kenya;Knock-in Mouse;malaria infection;Malaria Vaccines;Mali;Mediating;Modeling;Monoclonal Antibodies;Mus;neutralizing monoclonal antibodies;Phase I/II Trial;Phase II Clinical Trials;Plasmodium falciparum;Plasmodium vivax;prevent;Proteins;Role;Safety;safety assessment;Seasons;Sporozoites;T-Lymphocyte;Testing;transmission blocking;Vaccination;vaccine development;vaccine-induced antibodies;Vaccines;Yeasts

PROJECT_TITLE: Development of Pre-Erythrocytic Malaria Vaccines and antibodies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: MASON, ROSEMARIE  (contact)

PROJECT_TERMS: Antibodies;Antibody Therapy;Antigens;Chimeric Proteins;clinically relevant;Development;Employee;Glycoproteins;Hendra Virus;Henipavirus;HIV;HIV-1;human monoclonal antibodies;Individual;Intervention;invention;Link;Macaca mulatta;Messenger RNA;Methods;Monoclonal Antibodies;neutralizing antibody;neutralizing monoclonal antibodies;Nipah Virus;pathogen;pathogenic virus;Peripheral Blood Mononuclear Cell;prevent;Prevention;Reporting;Sampling Studies;screening;single cell technology;Vaccination;Virus;Virus Diseases;virus testing

PROJECT_TITLE: Monoclonal antibody isolation and characterization


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: acute flaccid myelitis;adaptive immune response;Adverse event;Antigens;Attenuated;Attenuated Vaccines;burden of illness;candidate identification;Childhood;Chimeric Proteins;clinical development;Clinical Research;Coronavirus;design;Disease Outbreaks;Dose;Enterovirus;Enterovirus 68;Enterovirus 71;Family Picornaviridae;Formulation;Genes;Goals;Health;Herpesviridae;Herpesvirus Vaccines;Human;Human Herpesvirus 4;Immune response;Immunity;Immunization;immunodeficiency;immunogenicity;Immunologics;Knowledge;Licensing;Life;Maternal antibody;Measles;Membrane Glycoproteins;Messenger RNA;Molecular Conformation;Mumps;Mus;nanoparticle;neutralizing antibody;neutralizing vaccine;next generation;nonhuman primate;novel vaccines;Paramyxovirus;paramyxovirus vaccine;Passive Transfer of Immunity;Persons;Phase;Pneumovirus;Population;preclinical study;Predisposition;Proteins;research clinical testing;respiratory;respiratory challenge;Respiratory syncytial virus;response;Secondary Immunization;Structural Protein;Structure;T-Lymphocyte;Testing;universal coronavirus vaccine;Vaccination;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;vaccine hesitancy;vaccine platform;Vaccine Research;Vaccines;Viral;Viral Fusion Proteins;Virus;Virus-like particle;Work;ZIKA

PROJECT_TITLE: Vaccine Research and Development for Endemic, Emerging, and Resurgent Viruses


PI_NAMEs: BORITZ, ELI  (contact)

PROJECT_TERMS: Affect;antiretroviral therapy;Blood specimen;CD4 Positive T Lymphocytes;Cell Physiology;Cell Proliferation;cell type;Cells;Chronic;Detection;Development;Emulsions;Epigenetic Process;Flow Cytometry;Gene Expression Profile;Genomic DNA;Goals;HIV;HIV Infections;Immunologics;in vivo;Individual;Institution;Interruption;Morbidity - disease rate;mortality;novel;Oils;Participant;Phenotype;Population;prevent;proteomic signature;Sorting;T-Lymphocyte Subsets;therapy design;Tissue Sample;transcriptomics;Virus;Virus Replication;Water;Work

PROJECT_TITLE: HIV persistence in vivo


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PROJECT_TERMS: Adolescent;Adult;Aerosols;Antigens;Attenuated;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;Birth;Blood;Bronchoalveolar Lavage;Cause of Death;CD8B1 gene;Cells;Cessation of life;Child;Confocal Microscopy;Development;Disease;disease transmission;Dose;experimental study;Flow Cytometry;follow-up;Frequencies;Genetic Transcription;global health;Goals;Granuloma;Growth;Health Priorities;HIV;Immune;Immune response;Immunity;Immunization;Immunize;Immunodominant Antigens;immunogenicity;Individual;Infant;Infection;Intravenous;Licensing;Lung;Lung Diseases;Lung infections;lymph nodes;M. tuberculosis genome;Maps;Meningitis;Miliary Tuberculosis;Modeling;mortality;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nonhuman primate;Pathology;Peptides;Persons;PET/CT scan;prevent;Pulmonary Tuberculosis;response;RNA;RNA vaccine;Route;Spleen;Structure of parenchyma of lung;T cell response;T-Lymphocyte;Tissues;Tuberculosis;Tuberculosis Vaccines;Vaccination;vaccine development;Vaccines;Virulent;X-Ray Computed Tomography

PROJECT_TITLE: Development of Vaccines to Prevent Tuberculosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Malaria;Malaria Vaccine;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: ANDREWS, SARAH  (contact)

PROJECT_TERMS: 2019-nCoV;B-Lymphocytes;Biological Assay;Clinical;clinical investigation;clinical trial analysis;Collaborations;Communicable Diseases;Development;Ebola;Emerging Communicable Diseases;Extramural Activities;Goals;HIV;Immunobiology;Immunology;Influenza;Licensure;Malaria;Prevention trial;programs;Public Health;Qualifying;Research Personnel;Therapeutic Trials;Vaccine Clinical Trial;vaccine development;Vaccine Research;vaccine trial;Vaccines;ZIKA

PROJECT_TITLE: Vaccine Immunology Program


PI_NAMEs: ROEDERER, MARIO  (contact)

PROJECT_TERMS: animal care;Animal Experimentation;animal model development;animal model selection;Animals;Caring;Data Collection;Development;improved;Laboratory Animals;Methodology;model development;Modeling;Monitor;operation;Policies;Principal Investigator;Procedures;programs;Regulation;Research;Research Personnel;research study;Research Support;translational research program;United States National Institutes of Health;Vaccine Research

PROJECT_TITLE: Laboratory Animal Research Support & Model Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;ACE2;Adjuvant;Affinity;antagonist;Antibodies;Antigens;B-Cell Activation;B-Lymphocytes;Binding;causal variant;COVID-19;COVID-19 vaccine;cross reactivity;Dendritic Cells;design;Effectiveness;Future;Generations;Goals;Growth;Humoral Immunities;Immune response;Immune system;Infection;Inflammatory;Innate Immune Response;insight;Macrophage;Mediating;Moderna COVID-19 vaccine;Molecular Probes;neutralizing antibody;nonhuman primate;pandemic disease;Peripheral;Plasma Cells;receptor;response;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Stains;Structure;T-Cell Activation;T-Lymphocyte;Therapeutic;Therapeutic Agents;Vaccination;vaccine development;vaccine efficacy;Vaccines;Variant;Virus;Virus Replication;Work

PROJECT_TITLE: Identification, structures and ontogenies of SARS-CoV-2 antibodies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Antibodies;Antigens;Carrier Proteins;Coupled;COVID-19;COVID-19 vaccine;Cryoelectron Microscopy;design;disabled;FDA approved;Generations;HIV-1;Immune Evasion;Immune response;immunogenic;immunogenicity;improved;Influenza;insight;Knowledge;nanoparticle;neutralizing antibody;NMR Spectroscopy;pathogen;prevent;response;SARS-CoV-2 infection;SARS-CoV-2 spike protein;self assembly;Structure;vaccine development;Vaccines;X-Ray Crystallography

PROJECT_TITLE: Immunogen Design for SARS-CoV-2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;ACE2;Adenoviruses;Antibodies;Antibody Response;Blood;Cell membrane;Chimeric Proteins;Clinical Data;Clinical Research;Clinical Trials;COVID-19;COVID-19 vaccine;Development;Devices;DNA;Formulation;global health;Goals;Health Priorities;Human;Immune;Immune response;Immunity;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;Infection;Lung;Membrane Fusion;Messenger RNA;Modeling;mucosal vaccination;mucosal vaccine;Nasal Lavage Fluid;Nucleic Acid Vaccines;pandemic disease;Protein Subunits;Proteins;receptor binding;response;RNA;RNA vaccine;Route;Safety;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Structure of mucous membrane of nose;T cell response;Vaccination;vaccine candidate;vaccine development;vaccine formulation;Vaccines;variants of concern;Viral;Viral Vaccines

PROJECT_TITLE: Development of a COVID Vaccine Model in NHP


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Affect;antibody conjugate;Antigens;B-Lymphocytes;Body Fluids;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;Custom;Evolution;Genomics;Human;Immune;Immunoglobulins;Immunologic Receptors;Infection;inflammatory marker;Libraries;Macaca mulatta;Measures;Metabolic Marker;microbial;microbial products;Modeling;Nature;next generation sequencing;nonhuman primate;Nucleic Acids;Plasma;Proteomics;Protocols documentation;response;Sampling;SARS-CoV-2 infection;systemic inflammatory response;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;transcriptome;transcriptomics;Vaccinated;Vaccination

PROJECT_TITLE: Innate and Adaptive Immune Responses in SARS-CoV-2 infection (COVID-19)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Blood specimen;CD8B1 gene;Characteristics;COVID-19;COVID-19 vaccination;cytokine;Disease;enzyme linked immunospot assay;Epitopes;Evolution;Future;Genomics;Goals;Individual;Infection;Intervention;Maps;Peptides;Peripheral Blood Mononuclear Cell;Proteome;recruit;response;Sampling;SARS-CoV-2 infection;Sorting;Stains;T cell response;T-Cell Receptor;T-Lymphocyte;Therapeutic;Time;transcriptomics;Vaccines;volunteer

PROJECT_TITLE: T cell analysis of COVID infection and vaccination


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Address;Anti-viral Response;Anti-viral Therapy;Antibody Response;Base Pairing;Bioinformatics;Clinical;Complex;Disease;Evolution;Gene Proteins;Gene Targeting;Generations;genetic analysis;genetic variant;Genetic Variation;Goals;high throughput technology;High-Throughput Nucleotide Sequencing;HIV;HIV drug resistance;Human;Immune response;in vivo;Individual;influenzavirus;insight;Intervention;Laboratories;Length;Mediating;Medical;Methods;Mutation;neutralizing antibody;novel;Outcome;Persons;Population;Population Heterogeneity;rare variant;Sampling;seasonal coronavirus;Sequence Analysis;single molecule;Therapeutic;Variant;Viral;Viral Genome;Virus;Virus Replication;Work

PROJECT_TITLE: High-throughput, single-molecule sequence analysis of virus populations in vivo


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Anatomy;B-Lymphocytes;Blood;Cell Separation;cell type;Clinical;Confocal Microscopy;COVID-19;deep sequencing;Disease;DNA Sequence Alteration;Evolution;Genetic Variation;Image;Image Cytometry;Immune response;Immunologics;in vivo;Individual;Laboratories;Lower respiratory tract structure;Lymphoid Cell;Memory B-Lymphocyte;Molecular Analysis;Mutation;Myeloid Cells;Outcome;Peripheral Blood Mononuclear Cell;Persons;Population;Prevalence;respiratory;Reverse Transcriptase Polymerase Chain Reaction;RNA;Sampling;SARS-CoV-2 genome;Sequence Analysis;single molecule;Site;stem;T cell response;Testing;Tissue Sample;Tissues;Upper respiratory tract;Virus;virus genetics

PROJECT_TITLE: Persistence and Evolution of SARS-CoV-2


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS Vaccines;Animal Model;Animals;Antibodies;Antibody-mediated protection;Binding;biodefense;Cells;Cessation of life;chikungunya;Clinical Trials;COVID-19 pandemic;cross reactivity;Development;Encephalitis Viruses;Enterovirus;Epitopes;Equilibrium;Equine Encephalomyelitis;Fatality rate;Goals;Homeostasis;Human;human pathogen;Immune response;Immunology;in vitro Model;Individual;Infection;Intervention;Lymphoid Tissue;Macaca;Macaca mulatta;man;Methodology;model development;Modeling;Monoclonal Antibodies;Monoclonal Antibody Therapy;Mucous Membrane;nonhuman primate;Norovirus;pathogen;Pathogenesis;Pathogenicity;Pattern;Persons;Phase;Primates;Privatization;SARS-CoV-2 infection;Surface;System;Testing;Therapeutic;therapeutic evaluation;Therapeutic Monoclonal Antibodies;trafficking;vaccine development;Vaccine Research;vaccine response;vaccine-induced antibodies;Vaccines;Venezuelan;Virus;Virus Diseases

PROJECT_TITLE: Development of NHP Models for Infectious Pathogens of Man


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Prevention

PROJECT_TERMS: 2019-nCoV;Antibody Therapy;Antigens;Cell Separation;Coronavirus;COVID-19;Development;Dissociation;Epitopes;Manuscripts;Monoclonal Antibodies;neutralizing monoclonal antibodies;Prevention;Resolution;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Severe Acute Respiratory Syndrome;Structure;vaccine development;variants of concern;Virus Diseases

PROJECT_TITLE: Monoclonal antibody isolation and characterization for COVID-19 Effort


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: Acceleration;Antigens;Biological Assay;cohort;Country;cross reactivity;Data;data resource;detection assay;Diagnostic;diagnostic assay;Early Diagnosis;genetic analysis;Human;human pathogen;Immune response;Immunologic Epidemiology;Immunologic Surveillance;Immunology procedure;Laboratories;microbial;Monoclonal Antibodies;novel virus;pandemic potential;pandemic preparedness;pandemic response;Population;Prevention;programs;prophylactic;Reagent;repository;response;Serology;Therapeutic;Translating;vaccine development;vaccine discovery;Zoonoses

PROJECT_TITLE: PREMISE: Pandemic Response Repository through Microbial and Immune Surveillance and Epidemiology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Antibody Response;Antigens;Bangladesh;bat-borne;candidate selection;Case Fatality Rates;Chimera organism;Chimeric Proteins;clinical development;Coughing;design;Development;Disease Outbreaks;effector T cell;Elements;Family;Family suidae;Fever;Headache;Henipavirus;Human;human disease;immunogenicity;improved;India;Licensing;Link;Malaysia;Messenger RNA;Molecular Conformation;Monoclonal Antibodies;monomer;mRNA delivery;Mus;Nervous System Disorder;neutralizing antibody;Nipah Virus;Paramyxovirus;Protein Engineering;Proteins;Structure;T cell response;Therapeutic;vaccine-induced antibodies;Vaccines;Virus

PROJECT_TITLE: Nipah virus vaccines and monoclonal antibodies