ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative The current immunomodulatory therapies of multiple sclerosis (MS) can only relieve the symptoms but are ineffective in curing the disease, so it is urgent for the field to find novel therapeutic approaches that can cure the disease, for instance by promoting remyelination. The central nervous system has great potential to regenerate oligodendrocytes and remyelinate in response to myelin damage, however the ability of remyelination is greatly diminished in the MS lesions. Here we aim to test the hypothesis that activating PPARβ/RXRα/Qki function will help remyelination in MS through two ways: 1) activating microglia’s function to clear myelin debris, consequently promoting oligodendrocyte regeneration, and 2) enhancing lipid generation of existing and newly generated oligodendrocytes.

PI_NAMEs: HU, JIAN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adult;Affect;Agonist;Bexarotene;Brain;Cells;Central Nervous System;chemokine;clinical practice;comparative;Complex;cytokine;Demyelinating Diseases;Demyelinations;Disease;Etiology;Exhibits;experimental study;Fatty Acids;Generations;Genes;Genetic;Genetic Transcription;Goals;High Fat Diet;Homeostasis;Immune system;immunomodulatory therapies;Impairment;insight;Lesion;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Microglia;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Names;Natural regeneration;novel therapeutic intervention;Oligodendroglia;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Persons;Phagocytes;Phagocytosis;prevent;promoter;Proteins;recruit;reduce symptoms;remyelination;response;Role;RXRA gene;Sampling;System;T-Lymphocyte;Testing;Therapeutic;Time;Transcriptional Regulation;transcriptomics;United States

PROJECT_TITLE: Promoting remyelination in multiple sclerosis by simultaneously modulating myelin debris clearance and myelin lipid synthesis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PI_NAMEs: GRABOWSKI, DAVID C (contact)

PROJECT_TERMS: Accounting;Address;Aging;American;Area;Assessment tool;beneficiary;Caring;Case Mixes;Chronic;Chronic Care;Chronic Obstructive Pulmonary Disease;Clinical;Code;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;comorbidity;Complex;Data;Data Set;Data Sources;Dementia;dementia care;design;Diabetes Mellitus;Diagnosis;Diffusion;Disease;dual eligible;efficacious treatment;Enrollment;Epidemiologist;Event;Family;Fee-for-Service Plans;Fee-for-Service Reimbursements;flexibility;frailty;Geriatric Psychiatry;Health;Health and Retirement Study;health data;Heart failure;Home;Impaired cognition;improved;Incentives;Individual;Internal Medicine;Investigation;Link;Medicaid;Medicaid eligibility;Medical;medical specialties;Medicare;Medicare claim;Methods;Modeling;Morbidity - disease rate;Neurology;Outcome;Patients;payment;Penetration;Pharmaceutical Preparations;Physicians;Policies;Population;predictive modeling;Predisposition;Probability;programs;provider networks;Psychoses;Reference Standards;Research;Research Personnel;research study;Risk;Risk Adjustment;Role;Sampling;Services;Severities;Severity of illness;Skilled Nursing Facilities;Sorting;Special needs plan;Standardization;Supportive care;Surveys;System;trend;Variant;Weight;Work

PROJECT_TITLE: Medicare and Beneficiaries with Dementia


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Delays and waits for needed health care result not only in lower patient satisfaction but adverse impacts on patient outcomes. While VHA has long struggled with access problems as a result of influxes of Veterans after wartime or in response to needs of new (e.g., traumatic brain injury) or aging cohorts (e.g., long term care), VHA's highly publicized access crisis in 2014 drew demands for immediate action. That action has taken the form of expansion of Veterans' access to community providers and policy and practice action within the VA. Improving how VHA manages access through more effective deployment of clinic personnel, resources, and processes to achieve timely access is a top priority. Oddly, the evidence base on effective access management strategies remains scant, requiring new approaches to accelerating how research can support VHA access improvement efforts. The proposed study aims to provide a national profile of how VHA has responded to the access crisis, and explore what drives or hinders successful efforts to improve access.

PI_NAMEs: ROSE, DANIELLE ELISE (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Agreement;Appointment;Area;care coordination;Caring;Characteristics;Client satisfaction;Clinic;cohort;Communication;Communities;Community Networks;Consensus;contextual factors;Contracts;Data;Data Sources;demographics;Development;evidence base;evidence based guidelines;Evidence based practice;experience;Fostering;Foundations;Future;Geography;Group Practice;Health Services Accessibility;Healthcare;Healthcare Systems;Heart Diseases;Hour;Human Resources;implementation evaluation;Improve Access;improved;indexing;Individual;informant;Intervention;Leadership;Link;Long-Term Care;Malignant Neoplasms;Measures;medical specialties;meetings;Mental Health;Methods;Morbidity - disease rate;mortality;novel strategies;Outcome;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Performance;Persons;physical conditioning;Policies;policy recommendation;post-traumatic stress;Primary Care;Primary Care Physician;Process;Provider;Quality of life;rapid growth;Recommendation;recruit;Reporting;Research;Resources;response;Role;Rural;rural area;Statutes and Laws;Survey Methodology;Surveys;Techniques;tool;Traumatic Brain Injury;uptake;Validation;Variant;Veterans;virtual;Wait Time;Whistle Blower;Work

PROJECT_TITLE: Impacts of Organizational Variations on Access Management

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Pediatric surgical disorders typically are related to congenital anomalies. This training grant aims to ensure that a pediatric surgeon workforce exists to be able to solve these conditions through innovative translational research. Surgeon trainees will spend dedicated time outside of their clinical residency acquiring the skill-set necessary to become successful independent researchers focused on childhood surgical diseases.

PI_NAMEs: BISCHOFF, JOYCE E.;GREENE, ARIN K. (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TITLE: Pediatric Surgeon-Scientist Training Program in Vascular Diseases


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PASADENA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The pace at which biological knowledge is published in the scientific literature far surpasses the ability of professional biocurators to collate and annotate such knowledge in a timely fashion. However, knowledgebases are a critical component of biological research whose utility depends on prompt entry of new data. Combining the dual benefits of text mining and community curation, the proposed ACKnowledge system, readily generalized, presents a novel approach to aiding curation by guiding authors to efficiently and accurately annotate their papers, thus quickly and reliably adding new information to knowledgebases.

PI_NAMEs: STERNBERG, PAUL WARREN (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Acceleration;Address;Algorithms;Area;Benchmarking;Biological;biological research;Biology;Bypass;Caenorhabditis elegans;Classification;Communities;Computer Assisted;Couples;Coupling;dashboard;Data;Data Collection;data submission;Databases;design;empowerment;FAIR principles;Feedback;Generations;genome resource;improved;Infrastructure;Ingestion;innovation;Knowledge;knowledgebase;Literature;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Manuals;member;Methods;Microbiology;Modeling;Names;Natural Language Processing;novel strategies;Paper;Process;Publications;Publishing;Readability;repository;Research;Research Personnel;Resources;Speed;Statistical Methods;System;Text;text searching;Time;tool;Training;Validation;WormBase

PROJECT_TITLE: Curation at scale: Integrating AI into community curation

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: RELEVANCE TO PUBLIC HEALTH  The proposed research is relevant to public health because understanding how to engineer cells that sense the environment and respond with high sensitivity is ultimately expected to ameliorate the diagnosis and treatment of a wide range of clinical indications, including diabetes, cancer, infectious diseases, and genetic disorders, thereby effectively improving human health.

PI_NAMEs: SEGATORI, LAURA  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Acute;Amplifiers;Behavior;Biological Markers;care outcomes;cell behavior;Cell Physiology;Cell surface;Cell Therapy;Cells;cellular engineering;Chronic;Clinic;Clinical;Communicable Diseases;Complex;conventional therapy;Cues;cytokine;Data;design;Detection;detection platform;Development;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Disease Marker;Dose;Dose Limiting;Drug Controls;Drug Delivery Systems;drug production;Drug Regulations;effective therapy;Encapsulated;Engineered Gene;Engineering;Environment;Evolution;extracellular;Gene Activation;Gene Amplification;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Diseases;Genetic Markers;Genetic Transcription;Goals;Health;Human;Human Pathology;Hypoxia;Immunomodulators;improved;innovation;Interleukin-2;Ligands;Link;Malignant Neoplasms;manufacture;Mediating;Medical;Modern Medicine;Monitor;monitoring device;non-Native;novel;Output;Pathologic Processes;Patients;Performance;Pharmaceutical Preparations;Physiological;Physiological Processes;prevent;Process;Production;programs;Property;Public Health;Quality of Care;real time monitoring;receptor;Regulation;Research;Resistance;Resolution;response;Science;sensor;Series;side effect;Signal Induction;Signal Transduction;Specificity;Stimulus;Synthetic Genes;System;systemic inflammatory response;systemic toxicity;technological innovation;technology development;technology platform;Testing;Therapeutic;therapeutically effective;therapy outcome;Time;tool;Toxic effect;Translating;Treatment outcome;treatment strategy;virtual

PROJECT_TITLE: Engineering mammalian gene activity sensor-actuator devices

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The goal of this renewal project is to use a high throughput CRISPR-Cas9-based pipeline for the systematic generation of gene knockout mutations in the model organism, C. elegans. Targets will be selected to be of high value to human geneticists and others interested in human biology and disease. Availability of these mutations will promote research in new areas of high importance to human health, in part by attracting additional scientists from these areas to explore this premier model organism.

PI_NAMEs: ROUGVIE, ANN E. (contact);STERNBERG, PAUL WARREN

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acceleration;Address;Alleles;Animal Model;animal resource;Animals;Area;ATP phosphohydrolase;Attention;Behavior;Biology;Biomedical Research;Caenorhabditis;Caenorhabditis elegans;Candidate Disease Gene;Categories;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collection;Communities;community-centered;CRISPR/Cas technology;Databases;Deposition;design;Development;Disease;Dissection;Event;Funding;G-Protein-Coupled Receptors;gene conservation;gene discovery;gene function;gene interaction;gene-editing approach;Generations;Genes;Genetic;genetic analysis;Genome;genome editing;genome resource;Goals;Guide RNA;Hand;Health;Human;Human Biology;human disease;Human Genetics;Information Distribution;interest;Invertebrates;Ion Channel;Knock-in;Knock-out;knockout gene;Laboratories;Lead;loss of function;loss of function mutation;MET gene;metabolomics;Microinjections;model organism;Modeling;Molecular;Molecular Biology;Molecular Genetics;Monitor;mutant;Mutation;Neurons;Oligonucleotides;Orthologous Gene;Pathway interactions;Peptide Hydrolases;Phase;Phenotype;Phosphotransferases;Physiology;Production;programs;Proteins;Proteomics;Quality Control;Reagent;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;screening;Site;Sorting;transcriptome sequencing;trend;United States National Institutes of Health;Variant;variant of unknown significance;web site;WormBase

PROJECT_TITLE: Enhancing the C. elegans animal resource through genome editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cannabidiol Research;Cannabinoid Research;Immunotherapy;Therapeutic Cannabinoid Research

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Cannabis use is expanding in cancer patients with limited knowledge in regard to its impact on cancer therapy. Our proposed study will look at how a newly identified immune checkpoint pathway serves as a resistant mechanism to cancer immunotherapy, and at the same time mediates antitumor immunosuppression caused by cannabis use.

PI_NAMEs: ZHU, YUWEN  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anandamide;antagonist;anti-cancer;anti-PD1 therapy;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;Anxiety;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;CAR T cell therapy;Cell Physiology;Cellular Metabolic Process;Clinic;Clinical;clinically relevant;CTLA4 gene;Data;Databases;effector T cell;efficacy evaluation;Exhibits;Family;Food;Functional disorder;G-Protein-Coupled Receptors;Genetic;genetic signature;Genetic Transcription;Genus Hippocampus;Goals;Human;humanized mouse;Hyperactivity;immune cell checkpoints;immune checkpoint;immune checkpoint blockers;Immune Evasion;Immunity;Immunosuppression;Immunotherapy;improved;Knowledge;Ligands;Malignant Neoplasms;marijuana use;Mediating;Melanoma;Melanoma patient;Metabolic;Modeling;Molecular;mouse model;Mus;neoplasm immunotherapy;neoplastic cell;Neuropeptides;new therapeutic target;novel;Outcome;Pathway interactions;PD-1 inhibitors;PD-1/PD-L1;Peptide Vaccines;Positioning Attribute;protein expression;Proteins;Publications;receptor;receptor-mediated signaling;Reporting;Research;Research Project Grants;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;T cell differentiation;T cell response;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;Transcript;tumor;Tumor Immunity;tumor microenvironment;Tumor Suppression;Up-Regulation;uptake

PROJECT_TITLE: The GPR171 pathway in cancer immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Integrins make up a large family of cell surface receptors, with at least one integrin found in every type of human cell. Changes in their overall shapes are important in establishing a link between the inside and outside of the cell. Therefore, defects in integrin structures are implicated in many diseases—including bleeding disorders, inflammation, and cancer—and thus are critical and proven drug targets. The platelet integrin, called αIIbβ3, is essential in platelet aggregation events. Dysregulated platelet aggregation is the trigger for abnormal thrombotic disorders such as heart attacks and strokes. There are currently three licensed αIIbβ3 drugs; however, these cause severe bleeding complications and are thus only used for a brief period of time (less than 72 hours). Using these clinical and preclinical drugs, our proposal aims to gain a new understanding of αIIbβ3 structure and function with the ultimate goal of positively impacting the broad integrin αIIbβ3 therapeutic space in the future.

PI_NAMEs: WANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Affinity;Agonist;antagonist;Architecture;Binding;Biochemical;Biological Assay;Biology;biophysical techniques;Blood Coagulation Disorders;Blood Platelets;Cell surface;Cell Surface Receptors;Cells;Cessation of life;Cholesterol;Classification;Clinical;clinical effect;clinically relevant;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Defect;Detergents;Development;Disease;Dose;Drug Design;Drug Targeting;Drug usage;effective therapy;EGF gene;Equilibrium;Event;experimental study;Family;Feasibility Studies;Fibrinogen;Future;Goals;Hematological Disease;Hemorrhage;Hour;Human;Hybrids;Imaging Techniques;Immunotherapy;improved;In Situ;in situ imaging;In Vitro;Inflammation;inhibitor;insight;Integral Membrane Protein;Integrins;Investigation;Ions;Kinetics;Laboratories;Length;Licensing;Ligands;Link;Macrophage-1 Antigen;Malignant Neoplasms;Maps;Membrane;microvesicles;Modeling;Molecular;Molecular Conformation;Molecular Probes;Monoclonal Antibodies;Myocardial Infarction;nanodisk;nanometer resolution;novel;particle;Pathology;Pharmaceutical Preparations;Physiological;Platelet Activation;Platelet aggregation;platelet function;pre-clinical;Process;Property;Protein Structure Initiative;Proteins;receptor;reconstitution;Regulation;Reporting;Research;Resolution;Roentgen Rays;Role;Shapes;Signal Transduction;skills;small molecule;Specimen;Stroke;structural biology;Structure;success;Surface;targeted treatment;Techniques;Therapeutic;therapeutic target;Thermodynamics;Thick;Thigh structure;Thrombasthenia;Thrombocytopenia;Thrombosis;thrombotic;Time;tomography;Vesicle;Visualization;von Willebrand Factor

PROJECT_TITLE: Investigation of the Cellular and Molecular Mechanisms of Thrombocyte Integrin Signaling

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative This project will generate extensive evidence on links between brain changes and behavior in adults with autism spectrum disorders between 40 and 70 years of age, for whom relevant data are extremely limited. Some specific focus will be on neuronal excitation:inhibition balance, which changes in aging. This systematic body of evidence will provide crucial information in the quest for predictors of long-term neurocognitive success or decline in ASD, thus serving as a first step to developing interventions to protect against such decline.

PI_NAMEs: CARPER, RUTH  (contact);MUELLER, RALPH-AXEL

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Acceleration;Adult;adult with autism spectrum disorder;adverse outcome;Affect;Affective;Age;age effect;age group;age related;Age Years;Aging;Amygdaloid structure;Anatomy;Anxiety;autism spectrum disorder;autistic;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral impairment;Biological;Brain;brain tissue;Characteristics;Child;Child Development;Cognition;Cognitive;cognitive ability;cognitive change;cognitive testing;cohort;Data;Data Collection;data mining;data resource;design;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Down-Regulation;early onset;Equilibrium;follow-up;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Genes;Glutamates;Impairment;individuals with autism spectrum disorder;insight;Insula of Reil;Interneurons;Intervention;Investigation;late life;Life;life span;Link;Literature;Machine Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;maladaptive behavior;Measurement;Measures;Mediating;Medical;Mental Health;middle age;Modeling;Morphology;Motor;Movement;MRI Scans;multimodality;neural;Neurobiology;Neurocognitive;Neurons;older adult;Outcome;Participant;Performance;Phenotype;Population;Predictive Factor;Process;Prognosis;Progress Reports;prospective;Public Health;rate of change;Recording of previous events;recruit;Research;response;Rest;Risk;Risk Factors;segregation;Signal Transduction;skills;social;Specificity;Subgroup;success;System;Testing;Time;Visual;Voice;Work;young adult

PROJECT_TITLE: The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Post-Traumatic Stress Disorder (PTSD);Precision Medicine;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Mood disorders including depression, bipolar, and post-traumatic stress disorder constitute the world's leading cause of disability and their burden is increasing. This proposal seeks to mitigate the burden of these related mood disorders by identifying patterns of brain structure and function indicative of a patient's likelihood of benefiting from various related interventions. This research has the potential to inform more personalized treatment strategies than are currently available and will likely further inform development of precision interventions targeting mood disorders.

PI_NAMEs: WADE, BENJAMIN SEAVEY CUTLER (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Anhedonia;anti-depressive agents;antidepressant effect;Anxiety Disorders;anxious;Architecture;Award;Behavioral;Biological Markers;biological systems;biomarker discovery;biomarker identification;Bipolar Disorder;Brain;career;Categories;classification algorithm;Clinical;Clinical Data;clinical predictors;Cognitive;Cognitive Therapy;cohort;Collaborations;Collection;convolutional neural network;Data;data archive;Data Set;data-driven model;Databases;deep learning;Development;Diagnostic;Dimensions;disability;Disease;Disease remission;diverse data;effective therapy;electric field;Electroconvulsive Therapy;empowerment;Etiology;Factor Analysis;Functional Imaging;Goals;Hamilton Rating Scale for Depression;Heterogeneity;hippocampal morphometry;Hippocampus;Image;imaging biomarker;Impaired cognition;improved;Individual;Infusion procedures;insight;Intervention;Ketamine;Knowledge;Left;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Modality;Modeling;Mood Disorders;multimodal fusion;Multimodal Imaging;multimodal neuroimaging;multimodality;National Institute of Mental Health;Negative Valence;network architecture;neural;neurobiological mechanism;Neurobiology;neuroimaging;novel;Participant;Patients;Pattern;personalized intervention;personalized medicine;Pharmacologic Substance;Pharmacotherapy;Phase;Post-Traumatic Stress Disorders;precision medicine;predict clinical outcome;predicting response;Prediction of Response to Therapy;Psychiatry;Psychopathology;random forest;Research;Research Domain Criteria;response;response biomarker;Rest;Severity of illness;side effect;Site;skills;Sleep Deprivation;Sleeplessness;statistical and machine learning;structural imaging;Structure;support vector machine;Symptoms;System;Therapeutic Intervention;therapy outcome;Training;Transcend;treatment group;treatment response;Treatment Side Effects;treatment strategy

PROJECT_TITLE: Data-Driven Models of Symptom Heterogeneity to Empower Transdiagnostic Multimodal Biomarker Discovery in Mood Disorders


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CORVALLIS

ORG_DEPT: PHYSICS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: 3D cell migration is of fundamental importance for both normal physiological processes such as in development, and disease progression such as cancer metastasis. Understanding the regulation and control mechanisms not only will advance our basic understanding of how cells mechanically interact with their environment, but will also lead to powerful strategies to facilitate therapeutic strategies in areas such as tissue regeneration, immune disorder and cancer.

PI_NAMEs: SUN, BO  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Anisotropy;Area;cancer therapy;cell motility;cell type;Cells;Chemicals;Collagen;Computer Models;Crosslinker;Cues;Dedications;deep learning;design;Development;digital;Dimensions;Disease Progression;DNA;DNA Sequence;Engineering;Environment;Epithelium;Exhibits;Extracellular Matrix;fascinate;Foundations;genetically modified cells;Goals;Human Biology;Image;Immune System Diseases;in vivo;Knowledge;Label;Lead;Life;Light;Malignant Neoplasms;Markov Chains;Measures;mechanical signal;mechanical stimulus;Mechanics;Mesenchymal;migration;Molecular;nanoparticle;Neoplasm Metastasis;Organoids;Pattern;Periodicals;Physics;Physiological Processes;programs;protein protein interaction;Regulation;Research;response;Role;Stress;synergism;Techniques;Testing;Therapeutic;Time;Tissue Engineering;tissue regeneration;Tissues;transcription factor

PROJECT_TITLE: Understanding the control mechanisms of 3D cell migration from new dimensions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Cancer mortality rates are projected to more than double in Sub-Saharan Africa (SSA) in the next two decades. In order to address this looming public health crisis, we propose a training program that will maximize the rigor of cancer research in SSA by training researchers to develop strategic and operational capacity that will generate new knowledge about the determinants of cancer risk and outcomes, and improve effectiveness of strategies for reducing risk and improve outcomes. The overarching goals of this training program are to 1) Develop and disseminate best practices to enable the highest quality cancer research in Africa; 2) Teach fundamental skills to those who conduct research in Africa; and 3) Create a cadre of individuals who can lead and support cancer research in SSA.

PI_NAMEs: REBBECK, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Africa;Africa South of the Sahara;African;African ancestry;anti-cancer research;Bilateral;Cancer Burden;cancer risk;career;career development;Death Rate;Education;Educational Curriculum;Educational process of instructing;Effectiveness;experience;Extramural Activities;falls;Funding;Goals;Grant;Health;improved;improved outcome;Individual;Knowledge;knowledge base;Lead;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant Neoplasms;men;Mentors;Oncology;Outcome;Participant;Principal Investigator;Program Development;programs;Prostate carcinoma;Public Health;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Risk Reduction;skills;Training;Training and Education;Training Programs

PROJECT_TITLE: BIDIRECTIONAL TRAINING TO ENHANCE CANCER RESEARCH CAPACITY IN AFRICA


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Our goal is to improving treatment options and lifespan of women with metastatic breast cancer by improving the understanding of the molecular co-evolution of the tumors and the immune system during tumor development and progression. Our expected outcomes include; 1) advancing our current understanding of resistance mechanisms; 2) determining how stress-induced HSP70 may regulate immunosuppression; and 3) testing the therapeutic utility of HSP70 inhibitor to improve effectiveness of current therapies in metastatic breast cancer. Our impact includes the identification of molecular targets that regulate critical steps in metastatic process and will lead to improved therapeutic approaches for the treatment of women with metastatic disease.

PI_NAMEs: KORKAYA, HASAN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Aggressive behavior;anti-tumor immune response;Antitumor Response;Binding;Biological Assay;cancer cell;cancer stem cell;cancer subtypes;Cell Death;Cell Death Induction;Cells;chemotherapy;Clinical;Clinical Data;Clinical Research;clinically relevant;Communication;CSF3 gene;cytokine;Cytokine Activation;Cytoprotection;Cytotoxic agent;Cytotoxic T-Lymphocytes;Data;Development;Disease;Disease Progression;Effectiveness;epithelial to mesenchymal transition;Epithelium;Generations;Goals;granulocyte;Heat-Shock Proteins 70;IL6 gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;Inflammatory;inhibitor;Knockout Mice;life span;Literature;Macrophage;Malignant Breast Neoplasm;Mediating;Mesenchymal;Metastatic breast cancer;metastatic process;Molecular;Molecular Target;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;Outcome;Pathway interactions;Patients;permissiveness;Phenotype;Play;pre-clinical;Process;Production;Prognosis;Progressive Disease;Property;Publishing;Research;resistance mechanism;response;Role;Sampling;Signal Transduction;Site;standard of care;Stress;Stromal Cells;Testing;Therapeutic;therapeutic evaluation;therapy resistant;Toll-like receptors;Transactivation;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Woman;women's outcomes;women's treatment;Work

PROJECT_TITLE: Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The NIMH identifies an urgent unmet need for science focused on improvement and development of interventions for individuals suffering from mental illness that are acceptable and easily disseminated to the service community and supported by policy makers. The UCSF Clinical Services Research Training Program trains junior investigators in the practices of clinical services research, relevant research methods, and professional skills. The program's success is reflected in the success of its graduates who have continued in clinical services research careers, many being leaders in the field, through academic/research positions, funded research programs and active dissemination of their research.

PI_NAMEs: LOEWY, RACHEL L.;PFIFFNER, LINDA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Clinical Services;Research Training;Training Programs


ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Multiple Myeloma is one of the most common cancers of blood cells; although the treatment has become more effective, multiple myeloma remains incurable. These cancer cells reside mainly in the bone marrow where they are supported by the normal bone marrow cells, particularly cells that form blood vessels. Our preliminary experiments implicated proteins called the EphB and ephrinB families in this interaction and our study is designed to determine if inhibiting the ability of these proteins to interact impairs the progression of this cancer.

PI_NAMEs: SASINE, JOSHUA P (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Animals;Antibodies;arm;Award;Binding Sites;Biology;bioluminescence imaging;Blood Cells;Blood Vessels;Bone Marrow;Bone Marrow Cells;burden of illness;Cancer Biology;cancer cell;Cancer Model;career;career development;cell behavior;cell motility;Cell Surface Receptors;Cell Therapy;Cells;Clinical;clinical care;clinical training;Collaborations;Data;Dedications;Dependence;design;Development;Development Plans;Disease;Disease Progression;Doctor of Philosophy;Drug resistance;Education;Endothelial Cells;Eph Family Receptors;Ephrin B Receptor;Ephrins;Event;experimental study;Family;Family member;Foundations;Genetic Transcription;Goals;Growth;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Immunoglobulin Fragments;Immunologics;Impairment;in vivo;in vivo evaluation;insight;Intervention;K-Series Research Career Programs;Knowledge;knowledge base;Laboratories;Life Expectancy;Ligands;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Medical;Membrane;Mentors;Mentorship;Multiple Myeloma;Mus;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;Patients;pharmacologic;Phenotype;Plasma Cells;Population;preservation;Process;programs;Proliferating;protective effect;Proteins;PTK2 gene;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;Relapse;Research;Research Training;Role;Scientist;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;skills;small hairpin RNA;STAT3 gene;stem cell biology;Stimulus;success;targeted treatment;Techniques;Testing;Therapeutic;tool;Training;transcriptome sequencing;tumor progression;Vascular Endothelial Cell;Work

PROJECT_TITLE: Decoupling Bidirectional EphB/ephrinB2 in Multiple Myeloma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. Although the success of this oncologic surgery primarily depends on obtaining clear surgical margins, tumor positive margin rates remain at approximately 30%. Because poor survival directly correlates with positive margin rate in head and neck cancer, we propose a clinical trial using a systemically injected contrast agent to determine if optical imaging during surgery can improve detection of tumor-positive margins in real-time. 1

PI_NAMEs: WARRAM, JASON MORGAN (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adjuvant;anti-cancer research;Area;arm;Blood Vessels;Caring;Clinical;Clinical Trials;Clinical Trials Design;Contrast Media;Curative Surgery;Decision Making;density;design;Detection;directed attention;Discipline of Nuclear Medicine;Educational workshop;Epidermal Growth Factor Receptor;Excision;Fc Receptor;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Head and Neck Cancer;Head and Neck Neoplasms;Human;imaging agent;improved;In Situ;Industry;Journals;Label;Malignant Neoplasms;meeting reports;meetings;Methodology;Microscopic;molecular marker;National Cancer Institute;open label;Operative Surgical Procedures;optical imaging;Outcome Measure;overexpression;Pathologist;Pathway interactions;Patients;primary outcome;prospective;Publications;Publishing;Quality of Care;receptor expression;Recommendation;Relapse;Reporting;Resected;Sampling Errors;Scientist;secondary outcome;Solid Neoplasm;Specimen;standard of care;success;Summary Reports;Surface;Surgeon;surgery outcome;Surgical Management;Surgical margins;Surgical Oncologist;Surgical Oncology;survival outcome;targeted imaging;Technology;Testing;Therapeutic antibodies;Time;Tissues;trial design;tumor;United States Food and Drug Administration;Visualization

PROJECT_TITLE: Reduction of Tumor-Positive Margins in Oncology Surgery

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The prevalence and severity of periodontitis increase with age, causing tooth loss in over 50% of adults 65 or older. Fragility fractures and delayed healing of the craniofacial bone cause significant morbidity and mortality in our aging population, and is in part due to the depleted regenerative potential of the aging stem cell pool. Our proposal focuses on determining factors that contribute to aging and senescence of the craniofacial stem cells, with the long-term goal of developing therapeutics directed to rejuvenate stem cells to counteract bone aging and treating periodontitis in elderly patients.

PI_NAMEs: KIM, REUBEN HAN-KYU (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acetylcysteine;Adult;Age;age effect;age group;age related;age related chronic disease;Age-Related Bone Loss;aged;Aging;aging population;aging related;alveolar bone;Alveolar Bone Loss;alveolar destruction;American;antioxidant enzyme;Antioxidants;B-Cell Activation;Behavior;Biogenesis;Biological Assay;bone aging;bone loss;Bone Marrow;bone marrow mesenchymal stem cell;bone mass;Bone remodeling;cell age;Cell Aging;cell injury;Cell Lineage;Cell Respiration;Cell Separation;Cells;Chronic;Connective Tissue;craniofacial;craniofacial bone;craniofacial repair;Defect;Diabetes Mellitus;diacetyldichlorofluorescein;Disease susceptibility;DNA Damage;Elderly;exhaustion;Exhibits;experimental study;fragility fracture;Goals;human old age (65+);immunoregulation;Impaired healing;Impairment;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;inflammatory bone loss;interest;Link;long bone;Mandible;Mediating;Mesenchymal Stem Cells;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel;old mice;older patient;Osteoblasts;osteogenic;Osteoporosis;Ovariectomy;overexpression;oxidative damage;Oxidative Regulation;Oxidative Stress;Periodontitis;Play;PPAR gamma;Prevalence;Process;Production;Proliferating;proliferation potential;Public Health;Quercetin;Reactive Oxygen Species;regeneration potential;Regulation;Rejuvenation;repaired;response;Risk Factors;Role;self-renewal;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Severities;Severity of illness;Signal Transduction;SIRT1 gene;skeletal;skeletal disorder;skeletal tissue;Skeleton;Societies;stem cell aging;stem cells;Stimulus;Stress;substantia spongiosa;Testing;Therapeutic;Tissues;Tooth Loss;Transcription Coactivator;Transcriptional Activation;Transcriptional Regulation;Trauma

PROJECT_TITLE: Regulation of Alveolar Bone Marrow MSC Senescence in Skeletal Aging and Periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance Respiratory viral infection of the susceptible epithelium is associated with the onset and progression of asthma. The Seattle Center will focus on the identification of common and distinct mechanisms that drive persistent T2 and non-T2 inflammation through epithelial interactions with immune cells that are in close contact with the epithelium in the context of viral infection. The results will provide the basis for novel therapeutics with efficacy in individuals with persistent T2 inflammation and non-T2 predominant disease.

PI_NAMEs: DEBLEY, JASON S;HALLSTRAND, TEAL S (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;airway epithelium;airway inflammation;airway remodeling;Asthma;asthma exacerbation;asthmatic;Bioinformatics;Biological Markers;Biological Response Modifier Therapy;Bronchodilator Agents;burden of illness;Cell Communication;Cell Culture Techniques;Cell Physiology;cell type;Cells;Child;Childhood;Chronic;Clinical;clinical phenotype;cytokine;Disease;Disease Progression;Disparity population;economic cost;Emergency department visit;eosinophil;Epithelial Cells;Epithelium;Genomics;Genotype;Goals;Heterogeneity;Hospitalization;Human;Immune;Immune response;Immune system;Immunology;Individual;Infiltration;Inflammasome;Inflammation;Inhalation;Interferons;intraepithelial;Lower respiratory tract structure;Lung;Macrophage;mast cell;Mediating;Methods;Minority Groups;Modeling;Morbidity - disease rate;neutrophil;novel therapeutics;Outcome;Persons;Phenotype;Play;Predisposition;Production;programs;Proteomics;pulmonary function decline;Resistance;respiratory;response;Rhinovirus;Rhinovirus infection;Role;Sampling;Schools;Severities;single cell sequencing;Support Groups;targeted treatment;Therapeutic;transcriptome sequencing;treatment response;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work;young adult

PROJECT_TITLE: Epithelial Immune Responses During Respiratory Viral Exacerbation of Asthma


NIH_SPENDING_CATS: Asthma;Lung

PI_NAMEs: HALLSTRAND, TEAL S (contact)

PROJECT_TERMS: airway epithelium;Asthma;asthma exacerbation;Collaborations;Communication;Communities;Complex;design;Development;Disease;Environment;Epithelium;Funding Opportunities;Goals;Immune;Immune response;Immune System Diseases;Infrastructure;Institution;interest;Leadership;National Institute of Allergy and Infectious Disease;Productivity;programs;Research;Research Personnel;Resources;respiratory;Sampling;Scientist;Site;Viral;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat neurodevelopmental disorders and brain tumors is critically dependent on fundamental understanding of cellular and molecular mechanisms that regulate neural stem cell self-renewal and differentiation in vivo. Research described in this proposal will uncover new and potentially evolutionarily conserved mechanisms governing these processes. If successful, it will have a broad impact on the understanding of human brain development and associated brain disorders.

PI_NAMEs: GUO, SU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adult;Anaphase;Anterior;Apical;Biochemical;Biophysics;Brain;Brain Diseases;Brain Neoplasms;Cell Cycle;Cell division;Cell Fate Control;Cell model;Cell Polarity;cell type;Cells;Complex;Coupled;Cytoplasm;Cytosol;Data;Daughter;daughter cell;density;Development;Diagnosis;Disease;Dynein ATPase;Embryo;Endosomes;Ensure;Equilibrium;Etiology;Exhibits;genetic approach;Homeostasis;Human;Image;imaging genetics;In Vitro;in vivo;in vivo imaging;insight;Intellectual functioning disability;Interphase;Invertebrates;Ligands;Light;Link;Microtubules;Mitosis;Mitotic;Molecular;Molecular Genetics;Morphogenesis;Mothers;Motility;Motor;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neuroglia;notch protein;novel therapeutics;Phosphorylation;Photobleaching;planar cell polarity;Play;Positioning Attribute;Process;progenitor;Property;Prosencephalon;protein complex;Proteins;Public Health;Radial;reconstruction;Recovery;repaired;Research;Role;segregation;self-renewal;Shapes;Signal Transduction;Specific qualifier value;stem cell self renewal;superresolution microscopy;System;telophase;Testing;therapeutic development;Time;Tissues;tumorigenesis;Work;Zebrafish

PROJECT_TITLE: Asymmetric Cell Division of Vertebrate Radial Glia Neural Progenitors

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


PI_NAMEs: DEBLEY, JASON S (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Air;airway epithelium;airway inflammation;airway remodeling;Asthma;asthma exacerbation;biobank;Biological Markers;Biological Models;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Lineage;Cells;Child;Childhood;Clinical;Clinical Data;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collecting Cell;Collection;Complex;conventional therapy;CRISPR/Cas technology;cytokine;Dependovirus;Disease;Donor person;Effector Cell;endotracheal;Enrollment;Epithelial Cells;Epithelium;Evaluation;experimental study;Gene Silencing;Genes;Genetic;Genetic Polymorphism;Genetic Screening;Genotype;Goals;Human;Human Resources;Immune;Immune response;Individual;Inflammasome;Inflammation;Informed Consent;Infrastructure;Inhalation;interest;Interferons;knock-down;life span;Link;Liquid substance;longitudinal design;Lung;Lung Transplantation;Macrophage;Modeling;Molecular;Monitor;monocyte;neutrophil;Operative Surgical Procedures;Outcome;patient oriented;Phenotype;Primary Cell Cultures;Production;programs;Protocols documentation;pulmonary function;pulmonary function decline;repaired;Research Personnel;Resources;respiratory;response;Rhinovirus;Rhinovirus infection;Ribonucleoproteins;Role;Schedule;Secure;Services;Single Nucleotide Polymorphism;single-cell RNA sequencing;small hairpin RNA;Sputum;T-Lymphocyte;Techniques;Testing;Time;Tissue Sample;Tube;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Human Airway Epithelial Cell Culture Core


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative

PI_NAMEs: MEINZEN-DERR, JAREEN  (contact);STRAWN, JEFFREY ROBERT;VAGAL, ACHALA SAMEER

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Abbreviations;Address;Adult;Area;Award;Basic Science;biomedical informatics;Biometry;Body mass index;Center for Translational Science Activities;Child;Clinical;Clinical and Translational Science Awards;clinical center;clinical implementation;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communities;community empowerment;community engagement;Data;data infrastructure;data management;Data Science;Development;disparity reduction;Dissemination and Implementation;drug development;Education;Educational process of instructing;Elderly;Environment;Epidemiology;Ethics;Ethnic Origin;experience;Family;Foundations;Gender;Genomics;Goals;Grant;Health;health care delivery;health disparity;health outcome disparity;Health system;Healthcare;improved;Individual;Informatics;Information Technology;innovation;Institution;Knowledge;Learning;learning community;life span;Measurable;Medical center;medical specialties;Medicine;member;Methodology;Methods;metropolitan;Mission;multidisciplinary;novel;Outcome;Participant;Patient Care;Patient Recruitments;Patients;Pediatric Hospitals;Population;population health;practice-based research network;programs;Provider;pyrolytic carbon;Race;recruit;Research;Research Design;Research Personnel;research to practice;Resources;Science;Site;Special Population;success;synergism;System;technology development;Time;Training;Translating;translational engagement;translational pipeline;Translational Research;translational scientist;Translations;Underrepresented Minority;Universities;Workforce Development

PROJECT_TITLE: Center for Clinical and Translational Science and Training


NIH_SPENDING_CATS: Asthma;Data Science;Lung;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ALTMAN, MATTHEW C. (contact)

PROJECT_TERMS: Archives;Asthma;asthma exacerbation;Bioinformatics;Chromatin;Clinical;Clinical Data;Consultations;Data;data acquisition;Data Analyses;data analysis pipeline;data integration;data management;Data Security;Data Set;data standards;Data Storage and Retrieval;data submission;data tools;database of Genotypes and Phenotypes;Disease;Ensure;Epithelium;experience;experimental analysis;Experimental Designs;Genetic;genomic data;Genomics;Goals;Immune;Immune response;Infrastructure;large scale data;member;Metadata;Methods;National Institute of Allergy and Infectious Disease;Phase;Process;repository;Research Institute;Research Personnel;Research Project Grants;respiratory;Sampling;Services;single-cell RNA sequencing;transcriptome sequencing;transcriptomics;Universities;Viral;Visualization;Washington

PROJECT_TITLE: The Bioinformatics and Data Management Core (BDMC)


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: HEUBI, JAMES E. (contact);KISSELA, BRETT M

PROJECT_TERMS: Area;base;clinical center;Clinical Research;Clinical Sciences;Collaborations;Communities;Country;Data;Data Science;disparity reduction;empowerment;Ensure;Health;health outcome disparity;Health system;Healthcare;improved;Individual;innovation;Institution;Investments;Leadership;Learning;life span;Medical center;Methods;metropolitan;Mission;multidisciplinary;Pediatric Hospitals;population health;Program Evaluation;Research;Research Personnel;Resources;Services;Structure;Training;Translating;translational engagement;Translational Research;Universities;Work


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: EGFR mutant NSCLC initially has a high response rate (70%) to EGFR tyrosine kinase inhibitors (TKIs), however, resistance to these drugs is inevitable. This project will use preclinical mouse models and human biospecimens to understand the role of the HGF-MET-TWIST1 pathway in mediating resistance to EGFR TKIs and if targeting TWIST1 can overcome or prevent resistance. Results of this proposal could lead to a new therapeutic paradigm for treatment of lung cancer through targeting EMT transcription factors.

PI_NAMEs: BURNS, TIMOTHY F. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Apoptosis;Apoptotic;BCL2L11 gene;Cell Line;Clinic;Clinical;clinically significant;Data;Development;Drug resistance;efficacy evaluation;efficacy testing;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epithelium;Erlotinib;experimental study;FDA approved;functional outcomes;Generations;Harmine;HGF gene;Human;In Vitro;in vivo;in vivo Model;inhibitor;Link;lung tumorigenesis;Malignant neoplasm of lung;Mediating;Mediator;Mesenchymal;Modeling;mouse model;Mus;mutant;new therapeutic target;next generation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;prevent;Proto-Oncogene Proteins c-akt;Publishing;Reporting;Repression;Resistance;response;Role;senescence;Signal Transduction;targeted treatment;Testing;Therapeutic;Time;transcription factor;translational impact;Treatment Efficacy;tumor;tumorigenesis;TWIST1 gene;Tyrosine Kinase Inhibitor;Wild Type Mouse;Xenograft procedure

PROJECT_TITLE: Targeting the HGF-MET-TWIST1 pathway to overcome EGFR TKI resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Clinical Research;Health Services


PHR: Relevance The results of this project will lead to a better understanding of the interplay between traditionally defined immune effector cells and the airway epithelium leading to the identification of new targets responsible for driving persistent T2 airway inflammation in asthma including components that persist despite standard therapy.

PROJECT_TERMS: Adrenal Cortex Hormones;airway epithelium;airway hyperresponsiveness;airway inflammation;Asthma;asthma exacerbation;Attenuated;Automobile Driving;Cell Communication;cell type;Cells;Child;Coculture Techniques;Complement;conventional therapy;cytokine;Dose;Effector Cell;Environment;eosinophil;Epithelial Cells;Epithelium;Functional disorder;Gene Expression;gene network;Genetic Transcription;Genotype;Human;ICAM1 gene;IL18 gene;Immune;Immune response;in vivo;Individual;Infection;Infiltration;Inflammation;Inhalation;Interferons;Laboratories;Lung;mast cell;Mediator;Modeling;mouse model;novel;Pathogenicity;Pathway interactions;programs;respiratory;response;Rhinovirus;Role;Signal Transduction;single-cell RNA sequencing;spatial relationship;System;therapeutic target;transcriptome sequencing;Transgenic Mice;Viral;Viral Respiratory Tract Infection;Work

PROJECT_TITLE: Epithelial Immune Cell Interactions in Persistent T2 Inflammation


PROJECT_TERMS: Address;Biological Sciences;clinical center;Clinical Sciences;Collaborations;college;Communities;community engaged research;community engagement;Consultations;Development;Discipline;Dissemination and Implementation;Education;Educational workshop;Effectiveness;Face;Funding;Grant;Health;Health Priorities;Healthcare Systems;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;knowledge integration;Leadership;Learning;learning community;multidisciplinary;National Center for Advancing Translational Sciences;Nature;Outcome;Process;programs;Publishing;Reporting;Research;Research Personnel;Role;Science;Training;Training Programs;translational pipeline;Translational Research;Universities;Work;working group;Writing


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This project aims to develop a novel computational paradigm for comprehensively characterizing and interpreting the causal system and its variability in functional brain networks. The findings will be translated in clinical studies of patients with different severity of neurological disorders to guide therapeutic practices, and particularly, post- concussive vestibular impairment syndrome will be used as one illustrative example in this study. Upon conclusion, we will understand the information transfer in resting state brain networks as well as its role in differentiating the subtypes of vestibular impairment.

PI_NAMEs: XU, NAN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Address;algorithm development;Alzheimer's Disease;Animal Experiments;Animal Model;Biological Markers;Biomedical Engineering;blood oxygen level dependent;Blood Vessels;Brain;Brain Concussion;Brain Diseases;Brain imaging;Brain region;career;career development;Clinical;clinical phenotype;clinical practice;Clinical Research;clinical training;Cognitive;cognitive neuroscience;Communication;Commuting;Data;Development;Doctor of Philosophy;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;hemodynamics;Human;Image Analysis;image translation;imaging biomarker;innovation;insight;Length;machine learning model;mathematical model;Measures;Mentors;method development;Methodology;Methods;Modeling;motion sensitivity;Multimodal Imaging;multimodality;multisensory;Nervous System Disorder;Neurology;Neurons;neurophysiology;Neurosciences;novel;Pathologic;Pathology;Pathway interactions;patient response;Patients;Pattern;Performance;Phase;Play;Post-Concussion Syndrome;Postdoctoral Fellow;Program Development;Rehabilitation therapy;Research Institute;Research Personnel;response;Rest;Rodent;Role;Severities;Signal Transduction;Slide;spatiotemporal;Symptoms;Syndrome;System;Techniques;Testing;Therapeutic;Time;Training;Translating;Uncertainty;Universities;Variant;Vestibular dysfunction;vestibular system;Visual Motion;visual-vestibular;Work

PROJECT_TITLE: Time-varying spatiotemporal causal interactions in the functional brain networks


NIH_SPENDING_CATS: Clinical Research;Pediatric

PROJECT_TERMS: Acceleration;acute care;Ally;Basic Science;Biological Markers;career;Clinical;clinical center;Clinical Data;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;Communities;community collaboration;community engaged research;Data;data dissemination;data management;Dedications;Dental;design;Development;Diagnostic tests;Discipline of Nursing;Disease;Faculty;Funding Opportunities;Future;Goals;Health;Health equity research;Health Occupations;high school;High School Student;innovation;Institution;interdisciplinary collaboration;Intervention;Laboratories;Medical;member;Methods;multidisciplinary;novel;Pilot Projects;Process;Program Development;programs;Research;Research Personnel;Resources;Science;science education;Students;success;Training;training opportunity;Training Programs;translational pipeline;Translational Research;translational scientist;translational study;Translations;undergraduate student;Universities;Workforce Development


NIH_SPENDING_CATS: Clinical Research

PROJECT_TERMS: Bayesian Analysis;Biometry;Clinical;clinical center;Clinical Research;Clinical Sciences;Collaborations;common rule;Communities;Complex;Consultations;Data;Data Analyses;data management;data sharing;design;Development;Epidemiologist;Epidemiology;Ethics;Fostering;Goals;Health system;Healthcare;improved;Informed Consent;Institutional Review Boards;Knowledge;Lead;Learning;Mediation;Methods;multidimensional data;Patient Rights;Procedures;Process;Regulation;Research;Research Design;Research Ethics;Research Methodology;Research Support;Staff Development;Statutes and Laws;Teacher Professional Development;Training;Training and Education;Translational Research;translational scientist;United States National Institutes of Health;Workforce Development


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Center for Translational Science Activities;Clinical;clinical center;Clinical Research;Clinical Sciences;community partners;Data;Development;Disease;empowerment;Environment;experience;first-in-human;Future;gene therapy;Goals;health disparity;Health Personnel;improved;Infrastructure;innovation;Knowledge;Monitor;multidisciplinary;Organoids;Participant;Process;process optimization;programs;Protocols documentation;Qualifying;Recording of previous events;recruit;Research;Research Design;Research Personnel;research study;Resources;skills training;Special Population;Surveys;tool;Training;Translational Research;translational research program;Underrepresented Populations;Underserved Population


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Sensory experiences activate patterns of neurons throughout cortex and hippocampus that reactivate together during quiet waking, potentially facilitating memory consolidation. However, the circuit-level effects of online activation and offline reactivation on learning are not well understood, as previous studies of learning and reactivation have not tracked large-scale activity patterns across days, and could not assess local circuit changes in neuromodulation and associated synaptic signals underlying plasticity. The proposed studies will use chronic two-photon imaging of calcium activity, local neuromodulation and downstream molecular signaling in large numbers of cortical neurons across days to link offline reactivation of specific recent experiences with next-day changes in behavioral performance and in cortical network dynamics during learning.

PI_NAMEs: ANDERMANN, MARK L (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Amygdaloid structure;Area;association cortex;Association Learning;Axon;Behavior;Behavioral;beta-adrenergic receptor;Biochemical;Brain region;Calcium;Cell Physiology;Cells;Chronic;Coupled;Cues;Cyclic AMP;Darkness;Data;Dendrites;Dendritic Spines;discrimination task;Electrophysiology (science);Emotional;Event;experience;Food;Genetic;GTP-Binding Proteins;Hippocampus;Image;improved;in vivo;Investigation;Joints;Lateral;Learning;Link;locus ceruleus structure;long term memory;Medial;member;memory consolidation;memory recall;Methods;Molecular;Mus;nerve supply;neural;Neuromodulator;neuronal patterning;Neuronal Plasticity;Neurons;neuroregulation;noradrenergic;Norepinephrine;optogenetics;Outcome;Pattern;Performance;Population;real time monitoring;response;Rewards;Role;Second Messenger Systems;Sensory;sensory cortex;Signal Transduction;Synapses;Synaptic plasticity;Task Performances;Testing;tool;Training;two-photon;Visual;visual discrimination;Visualization

PROJECT_TITLE: Roles of cortical neuromodulation and offline reactivation in memory consolidation of emotionally salient visual experiences

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Rehabilitation

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Older adult cancer survivors (≥65 years, ≥1-year post-treatment) are an understudied yet uniquely high-risk group for untreated depression in need of novel mental health treatments and delivery strategies across cancer settings. Despite the rapidly growing number of older adult cancer survivors, no studies have evaluated the implementation of evidence-baseddepression treatment for older adults through cancersurvivorship clinics. The current proposal adopts an implementation science framework to evaluate the preliminary efficacy and implementation outcomes of social work delivered Behavioral Activation via telephone for older adult cancer survivors, with the ultimate goal of increasing engagement in evidence based depression treatment.

PI_NAMEs: SARACINO, REBECCA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adopted;Adoption;Advanced Practice Nurse;Aftercare;Age;age group;Anxiety;Area;arm;barrier to care;Behavior;Behavioral;Behavioral trial;Cancer Center;Cancer Survivor;Cancer Survivorship;cancer therapy;care delivery;career;Caring;Chronic Disease;Clinic;Clinical;clinically significant;Communities;community setting;comorbidity;coping;cost effective;COVID-19;Data Analyses;Depressed mood;depressive symptoms;design;Development;Disabling;Dissemination and Implementation;dissemination science;efficacy outcomes;Ensure;environmental enrichment for laboratory animals;evidence base;Evidence based intervention;Exercise;experience;Fatigue;Feedback;follow-up;Frequencies;functional status;Funding;geriatric depression;geriatric mental health;Geriatric Psychiatry;Goals;Guidelines;Health Personnel;Health Resources;high risk population;human old age (65+);implementation evaluation;implementation framework;implementation outcomes;implementation research;implementation science;Individual;Intervention;K-Series Research Career Programs;Malignant Neoplasms;Manuals;Medical;Memorial Sloan-Kettering Cancer Center;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;mild cognitive impairment;National Comprehensive Cancer Network;novel;older adult;Oncology;Patients;Penetration;Pilot Projects;Population;primary outcome;Procedures;Provider;Psychiatrist;Psychological reinforcement;Psychologist;Psychosocial Assessment and Care;Psychotherapy;Public Health;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Sampling;Scientist;screening;secondary outcome;Services;social cognitive theory;Social Distance;Social Interaction;Social Work;Social Workers;success;Suicide;survivorship;symposium;Symptoms;System;Telephone;telephone delivery;Time;Training;treatment strategy;United States National Institutes of Health;working group

PROJECT_TITLE: Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: acute care;Adopted;clinical center;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;Data;data integration;Health;Health system;Human Subject Research;improved;innovation;Learning;life span;multi-site trial;multidisciplinary;Research;Research Personnel;Resources;Services;Site;success;Time;Training;Translational Research


PROJECT_TERMS: Acceleration;Caring;Clinical;clinical care;clinical center;Clinical Research;Clinical Sciences;design;Health;Health system;Healthcare;improved outcome;informatics infrastructure;Intervention;Knowledge;Laboratories;Learning;Organizational Models;System;Testing;Training;Translational Research;Work


NIH_SPENDING_CATS: Aging

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE The Health and Retirement Study (HRS) is the premier data set worldwide for the study of aging in all its complexities. The RAND HRS Longitudinal File and its supplementary data files, that constitute the RAND HRS Data System, have been instrumental in facilitating and increasing the use of the HRS in the work of thousands of researchers in the U.S. and around the world. This project will substantially expand the content of the RAND HRS Data System to realize the full potential of the HRS and to facilitate rigorous multidisciplinary research on health and aging.

PI_NAMEs: ROHWEDDER, SUSANN  (contact);WEIR, DAVID R.

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Activities of Daily Living;Address;Advisory Committees;Affect;Aging;Area;care giving burden;Caring;Code;Complement;Complex;Complex Variables;Consultations;Data;Data Collection;Data Element;Data Files;data infrastructure;Data Security;Data Set;Dementia;Derivation procedure;Development;Dimensions;disability;Discipline;Disparity;Epidemiology;experience;Family member;Fostering;Health;Health and Retirement Study;health disparity;Healthcare;high standard;human old age (65+);improved;indexing;Individual;informal care;Information Systems;innovation;Interdisciplinary Study;Investigation;Knowledge;Long-Term Care;longitudinal analysis;Longitudinal Studies;Measures;Medicine;Mental Health;Methodology;Methods;Michigan;Older Population;Parents;Pensions;Personal Satisfaction;Persons;physical conditioning;Preparation;Process;Production;Productivity;Protocols documentation;psychosocial;Questionnaires;Recommendation;Research;Research Personnel;Research Support;Respondent;Sampling;Social Sciences;Social Security;Source;Speed;Structure;Surveys;systematic review;Technical Expertise;Time;Universities;Update;user-friendly;Work

PROJECT_TITLE: Expanding the RAND HRS Data System to Better Support Research on Health and Aging

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

PROJECT_TERMS: abdominal wall;Address;Agreement;Algorithms;Antibiotics;Birth;Censuses;Child;Childhood;clinical center;Clinical Sciences;Communities;Data;data de-identification;data hub;data integration;data repository;Data Set;data sharing;Defect;Disease susceptibility;Electronic Health Record;Environmental Exposure;Equipment and supply inventories;Goals;Grant;Health;Hepatitis C;Hospitals;improved;Individual;Infant;Institutional Review Boards;life span;Link;Medical center;Mothers;multidisciplinary;Neonatal;Neonatal Abstinence Syndrome;Newborn Infant;opioid exposure;Outcome;Ownership;Pediatric Hospitals;Peer Review;Perinatal;Phase;population based;population health;post pregnancy;Privacy;programs;Protocols documentation;Publications;Publishing;Records;Research;social determinants;Training;Translational Research;trend;Universities;Vital Statistics


PHR: Project 2 Narrative Effective treatments for non-type 2 (T2) asthma are lacking for children and adults. Using bronchial airway epithelial cells from well characterized cohorts of children and adults with and without asthma we will conduct mechanistic experiments using organotypic models to improve understanding of the role of the airway epithelium in coordinating immune cells that drive airway inflammation and remodeling, and influence exacerbations, lung function, and inflammatory signatures in non-T2 asthma. Results from this Project will be highly impactful to the field with potential to identify novel therapeutic targets for non-T2 asthma to prevent exacerbations and lung function decline for children and adults with non-T2 asthma.

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;airway epithelium;airway inflammation;airway remodeling;Asthma;asthma exacerbation;asthmatic;asthmatic airway;Automobile Driving;Bioinformatics;Biological Assay;Biological Products;biomarker signature;Caspase;Cell model;cell type;Cells;Child;Chromatin;Clinical;Coculture Techniques;cohort;cost;CSF3 gene;cytokine;Data;effective therapy;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Exhibits;experimental study;Frequencies;Gene Expression;Gene Proteins;Genes;Genetic;genomic locus;Genomics;Healthcare Systems;Human;humanized mouse;Immune;Immune response;improved;in vivo;in vivo evaluation;in vivo Model;Incidence;Individual;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Inhalation;Interferons;Interleukin-1 beta;interleukin-17C;Link;Lung;Macrophage;Modeling;Morbidity - disease rate;Mouse Strains;neutrophil;Neutrophil Activation;new therapeutic target;Obesity;Outcome;Pathway interactions;Patients;Pattern;Physiology;prevent;Production;Proteins;pulmonary function;pulmonary function decline;Quantitative Trait Loci;Reporting;Resistance;respiratory;response;Rhinovirus;Rhinovirus infection;Role;Smoking;Techniques;Testing;TNF gene;TNFSF10 gene;transcriptomics;Transposase;Viral;Virus;Virus Diseases

PROJECT_TITLE: Epithelial activation of airway inflammation in patients with non-T2 asthma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed mechanistic trial will utilize mindfulness training to permit examination of questions about the causal role of emotion regulation strategies linked to the striving persistent behavioral style in driving mental health and health morbidities among BIPOC78. The proposed Project STRIVE (STudents RIsing aboVE) will identify BIPOC students who are academically resilient in the face of disadvantage and will offer a tailored mindfulness intervention targeting self-regulation processes as a putative mechanism to interrupt the links between the striving persistent behavioral style and negative health outcomes. We propose a multisite randomized trial to the effects of the STRIVE intervention on putative self-regulation mechanisms, health and mental health outcomes, and to examine the mechanistic model linking striving persistent behavioral style to health and mental health morbidities.

PI_NAMEs: LAU, ANNA SHAN-LAI (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Academic achievement;Academic skills;Achievement;Adolescent;Aftercare;allostatic load;Anxiety;anxiety symptoms;Asian Americans;attentional control;Automobile Driving;Behavioral;Biological;Biological Markers;Black race;Black, Indigenous, People of Color;Blood Pressure;Body mass index;Cardiovascular Diseases;Cardiovascular system;children of color;Chronic stress;college;Color;Complex;cost;depressive symptoms;Development;Disadvantaged;early life adversity;early life stress;Educational Curriculum;Eligibility Determination;emotion regulation;Emotions;Enrollment;ethnic minority;examination questions;Exhibits;experience;externalizing behavior;First Generation College Students;Health;Health Care Costs;health disparity;Hip region structure;Hydrocortisone;inclusion criteria;indexing;Informal Social Control;Institutional Racism;Interruption;Intervention;intervention effect;Latinx;Link;marginalized community;Mediating;Mediator;Mental Health;Metabolic;Metabolic syndrome;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;minority children;minority student;Modeling;Morbidity - disease rate;Neck;Neurosecretory Systems;Outcome;physical conditioning;Physiological;Population;Poverty;prevent;Prevention trial;preventive intervention;Problem behavior;Process;Public Participation;Qualifying;Race;Randomized;randomized trial;Research;resilience;Resources;Risk;Role;Schools;Secondary Schools;Site;skills;social capital;Socialization;socioeconomic disadvantage;Students;Study Skills;success;Symptoms;Testing;therapy design;Youth

PROJECT_TITLE: Project STRIVE (STudents RIsing above) - Offsetting the health and mental health costs of resilience

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The UCSD Training Program in Reproductive Sciences takes a multidisciplinary approach to prepare physician- scientists and reproductive biologists to become the future leaders in reproductive research. Postdoctoral scholars with Ph.D. and/or M.D. degrees are trained in the field of reproductive biology through advanced basic research experiences and/or engaging in clinical investigation of reproductive disorders. A cohesive, highly interactive group of faculty mentors from the Department of Obstetrics, Gynecology, and Reproductive Sciences and the Departments of Medicine and Pathology with complementary interests, co-authored publications, shared grants, and balanced clinical, translational, and basic science backgrounds, provides intensive research training and career development to foster the future careers of outstanding postdoctoral and clinical fellow trainees.

PI_NAMEs: MELLON, PAMELA L (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Reproductive Sciences;Training

PROJECT_TITLE: Training in Reproductive Sciences


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LIVERPOOL

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE

ORG_ZIPCODE: L3 5QA

PHR: Public Health Relevance/Narrative Over the last five years the annual reductions in malaria illness and deaths in sub-Saharan Africa have stalled. The previous success of malaria control has been largely due to the scale-up in the distribution of long lasting insecticidal nets and it is thought that insecticide resistance is one of the causes of the slow down . The goal of this research project is to embed genomic surveillance approaches into ongoing vector control trials to accurately quantify the epidemiological impact of resistance and to provide the resources to mitigate its impact on malaria control programmes.

PI_NAMEs: DONNELLY, MARTIN JAMES (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adoption;Africa;Africa South of the Sahara;African;Anopheles gambiae;Anopheles Genus;Award;Biological Assay;biomarker identification;biomarker panel;Cessation of life;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;control trial;Country;CRISPR/Cas technology;Culicidae;Data;Development;Diagnostic;diagnostic biomarker;Economic Development;epidemiologic data;Epidemiology;Evaluation;Evolution;Falciparum Malaria;functional genomics;Future;Gene Frequency;Genetic;Genetic Markers;Genetic Models;genetic resistance;Genetic Transformation;genetic variant;Genome;genome sequencing;genome wide association study;Genomic approach;Genomic Segment;genomic signature;Genomics;Goals;Heterogeneity;improved;Insecticide Resistance;Insecticides;Intervention;Kenya;Malaria;malaria infection;malaria transmission;Maps;Marker Discovery;Methods;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;novel;Outcome;Population;predictive modeling;Predisposition;programs;public health relevance;pyrethroid;Randomized, Controlled Trials;Recommendation;Research Project Grants;Resistance;Resistance development;resistance mechanism;Resources;scale up;screening;screening panel;Site;Speed;success;sugar;Surveillance Program;Technology;Testing;tool;transmission process;Treatment Efficacy;Uganda;Variant;vector;vector control;whole genome;Work

PROJECT_TITLE: Genome-based diagnostics for mapping, monitoring and management of insecticide resistance in major African malaria vectors

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE This relevance of this proposal centers on illuminating the mechanisms by which a rare but highly-lethal type of metastatic prostate cancer – known as Androgen Receptor Pathway-Independent Prostate Cancers (APIPC) – is able to flourish and progress. The incidence of this form of the disease is increasing due to the widespread use of potent AR pathway inhibitors, and represents a significant challenge in terms of clinical management. Successful completion of this project will yield actionable targets and potential therapeutics.

PI_NAMEs: NELSON, PETER S (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: abiraterone;Address;Adrenal Glands;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;androgenic;Androgens;antagonist;autocrine;Biological Models;Carcinoma;cell growth;Cell Line;Cell Survival;Cells;Characteristics;Classification;Clinical;Clinical Management;Clinical Trials;combinatorial;CYP17A1 gene;dehydroepiandrosterone;derepression;design;Development;Disease;disease model;Drug Combinations;Drug Targeting;effectiveness evaluation;Endocrine;enzalutamide;Epigenetic Process;epigenome;epigenomics;Epithelium;Event;Feedback;Fibroblast Growth Factor;Generations;Genetic;Genome;Genomics;Genotype;Growth;Heterogeneity;HIV;Human;In complete remission;in vivo Model;Incidence;Individual;infectious disease treatment;inhibitor;Intercept;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;Modeling;Molecular;neoplastic cell;Neuroendocrine Carcinoma;Neurosecretory Systems;Oncogenes;Oncogenic;Outcome Assessment;Pathway interactions;patient derived xenograft model;pharmacologic;Phenotype;pressure;programs;Prostate;prostate cancer cell;Prostate carcinoma;Receptor Activation;Receptor Signaling;Regulatory Pathway;Resistance;Resistance development;resistance mechanism;Signal Transduction;Signal Transduction Pathway;Source;success;targeted treatment;Testing;Testis;Testosterone;Therapeutic;therapeutic effectiveness;therapeutically effective;tumor;tumor progression

PROJECT_TITLE: Defining and Targeting Lineage Transition Programs Operative in AR Pathway Independent Prostate Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Neurodevelopmental disabilities affect 10% of all families in the United States. Researchers are urgently needed who are able to apply cutting-edge, interdisciplinary research methods to elucidate the pathogenesis and pathophysiology of these disorders so that new and more effective therapeutic interventions can be identified. This program strives to fill this need.

PI_NAMEs: EISCH, AMELIA J (contact);MARSH, ERIC D

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Training Program in Neurodevelopmental Disabilities


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative  Foreign-born Latinos in the United States are at risk for poor health outcomes, including poor outcomes for cancer. It is uncertain whether or not they receive fewer prevention services for cancer, and if so, which specific factors may be most responsible for the lower receipt of these services. This project will use a highly innovative electronic health record database that contains country of birth information and is linked to community information in order provide policy makers and healthcare providers better information about what cancer prevention services their patients or community members are most at risk for underutilizing.

PI_NAMEs: HEINTZMAN, JOHN  (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Accounting;Address;Advisory Committees;authority;barrier to care;Behavior;Birth;cancer care;cancer prevention;Caring;Categories;Cervical Cancer Screening;Clinical;colorectal cancer screening;Communities;Community Health Education;Community Health Networks;community-level factor;Country;Cuban;Data;Data Linkages;data resource;Data Set;Databases;Demographic Factors;demographics;Disparity;Education;Educational Status;Electronic Health Record;Ethnic Origin;Ethnic Population;ethnic segregation;experience;Fright;Geography;Health;health care availability;health care service utilization;health data;health disparity;Health Personnel;Health Services Research;Health system;Healthcare;Human Papilloma Virus Vaccination;Immigrant;Immigration;Immunization;improved;Individual;innovation;Insurance;Intervention;Knowledge;Language;Latino;Latino Population;Leadership;Link;Literature;longitudinal dataset;lung cancer screening;Malignant Neoplasms;Mammography;member;Mexican;Morbidity - disease rate;mortality;Neighborhood Health Center;Not Hispanic or Latino;Outcome;patient oriented;patient-level barriers;Patients;point of care;Policies;Policy Maker;poor communities;poor health outcome;Population;population health;Population Intervention;Positioning Attribute;Poverty;Prevention;prevention service;Preventive;Preventive care;Preventive service;Provider;Public Health;Race;Recommendation;Reporting;Research;Research Design;Research Personnel;Resource Allocation;Risk;risk stratification;Rural;rurality;safety net;screening;Screening for cancer;screening services;Service provision;service utilization;Services;Smoker;social factors;social health determinants;Spanish;Subgroup;Time;Tobacco Use Cessation;Uninsured;United States;United States Preventative Services Task Force

PROJECT_TITLE: FRONTIERS: Foreign-Born Latinos Cancer Screening

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Cognitive training and Tai Chi exercise lifestyle interventions have shown success in improving cognitive, functional, and mood-related outcomes in both cognitively impaired and normal samples, however these interventions have not been considered in patients diagnosed earlier in life (“early-onset Alzheimer’s Disease”; EOAD). We propose to collect preliminary data to investigate the feasibility and effect of a combined lifestyle intervention on short-term and long-term cognition, functioning, and mood in amyloid-positive participants with EOAD from the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) cohort. Achieving these aims will result in information on feasibility and initial efficacy of administering this lifestyle intervention to this under- served population, with successful improvement of cognition and psychosocial factors in EOAD having implications for patients and families, healthcare practice, policy, and other forms of AD.

PI_NAMEs: HAMMERS, DUSTIN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: active control;active control group;Adherence;Aftercare;aged;Aggressive course;Alzheimer's Disease;Alzheimer's disease test;Amyloid;Behavior Therapy;Biometry;career;career development;Classification;Clinical;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive training;cohort;Cohort Studies;comparison control;Complement;computerized;Data;Development Plans;Diagnosis;Disease;Early Diagnosis;Early Onset Alzheimer Disease;Early treatment;Educational workshop;Ensure;Environment;Exercise;exercise intervention;exercise program;experience;Family;feasibility testing;follow-up;Funding;Future;Goals;Health Personnel;Healthcare;Height;Hour;Impaired cognition;improved;improved outcome;Indiana;Individual;Institution;Intervention;Intervention Trial;Investigation;Knowledge;Learning;Life;lifestyle intervention;Literature;Longitudinal Studies;men;Mentors;mid-career faculty;Mission;Modeling;Monitor;Moods;National Institute on Aging;Nature;Nerve Degeneration;Neurodegenerative Disorders;Occupational;operation;Outcome;Outcome Assessment;Participant;participant retention;patient engagement;patient oriented;Patients;pharmacologic;pilot test;Policies;Population;Positioning Attribute;primary outcome;programs;Psychosocial Factor;Randomized;rare condition;Research;Research Personnel;response;Sample Size;Sampling;Scientist;Series;Severities;Severity of illness;Site;statistics;success;Tai Ji;Testing;Training;Training Programs;treatment arm;treatment response;Underserved Population;United States National Institutes of Health;Universities;Visit;Woman;Work

PROJECT_TITLE: Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Public health relevance: Individuals addicted to cocaine face great difficulty in suppressing their drive to consume cocaine, even long after their previous use of the drug. The proposed studies will focus on understanding those neural systems that underlie the suppression and inhibition of cocaine seeking. The findings of this work may have significant future benefit in the creation of better treatments that strengthen the ability to inhibit cocaine use.

PI_NAMEs: LALUMIERE, RYAN T (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Amygdaloid structure;Behavior;Behavioral;Brain region;Cell Nucleus;Cocaine;Cocaine Dependence;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Consumption;craving;Custom;Data;design;Development;Drug usage;effective therapy;Elements;Etiology;experimental study;Extinction;Face;Failure;Frequencies;Future;Goals;Heterogeneity;Hippocampus;Human;Impairment;Implant;Individual;insight;Knowledge;Laboratories;learning extinction;Medial;Mediating;Modeling;multi-electrode arrays;neural;neural circuit;Neural Pathways;Neurons;Neurosciences;novel strategies;Nucleus Accumbens;optogenetics;Output;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Play;Prefrontal Cortex;Process;public health relevance;Rattus;Relapse;Research;Rodent;Role;Site;Structure;Structure of paraventricular nucleus of thalamus;System;Testing;Thalamic structure;Training;Work

PROJECT_TITLE: Neural systems mediating the extinction and inhibition of cocaine seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PHR: PROJECT NARRATIVE  HBV-associated diseases such as liver fibrosis, cirrhosis and hepatocellular carcinoma lead to significantly decreased quality of life and even death. HBV infection is maintained by a persistent viral genome called cccDNA minichromosome, which cannot be eradicated or inactivated by currently approved drugs. This research project aims to elucidate the mechanism of epigenetic regulation of cccDNA transcription, which will potentially discover new antiviral targets for development of epigenetic therapy against chronic hepatitis B.

PI_NAMEs: GUO, HAITAO  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Adverse effects;Affect;analog;Anti-viral Agents;Biology;bisulfite sequencing;Cell Culture Techniques;Cell Line;Cell Nucleus;Cells;Cessation of life;Chromatin;chromatin immunoprecipitation;chromosome conformation capture;Chromosomes;Chronic Hepatitis B;chronic infection;Circular DNA;Cirrhosis;Clinical;comparative;comparative genomics;Coupled;Dependence;Development;Disease;DNA;DNA Repair;Drug resistance;effective therapy;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenetic therapy;epigenome;Episome;Exhibits;experimental study;Genetic Transcription;Genomic Segment;Goals;Hepatitis B Virus;Hepatocyte;High-Throughput Nucleotide Sequencing;Histones;HMGB1 gene;Individual;Integration Host Factors;Interferon alpha;Lead;Life Cycle Stages;Liver;Liver Fibrosis;Longevity;loss of function;Maps;Mediating;Methods;Methylation;Modeling;Modification;non-histone protein;novel;Nuclear;Outcome;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Polymerase;Post-Translational Protein Processing;Primary carcinoma of the liver cells;Productivity;promoter;Proteins;Proteomics;Public Health;Quality of life;Relaxation;Reporter;Repression;Research Project Grants;response;Risk Factors;Role;stable cell line;System;therapeutic development;Trans-Activators;Treatment Failure;treatment strategy;Validation;Variant;Viral;Viral Genome;viral genomics;Viral Regulatory Proteins;Virus;Virus Diseases;Virus Inhibitors;Virus Replication

PROJECT_TITLE: Epigenetic Regulation of HBV cccDNA Transcription

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Chemical modifications to histone proteins coordinate gene expression by helping to turn specific genes “on” or “off” in human cells. This project will elucidate how a subset of these modifications, called acylations, are regulated by metabolism and what impacts these acylations have on gene expression. By defining these specific cellular mechanisms, the project will reveal new therapeutic strategies to combat diseases associated with epigenetic and metabolic dysregulation.

PI_NAMEs: DIEHL, KATHARINE  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acyl Coenzyme A;Acylation;Acyltransferase;Affinity;Binding Proteins;Biosensor;Cells;Chemicals;Chromatin;combat;Communication;Disease;DNA;Enzymes;Epigenetic Process;epigenetic regulation;Gene Expression;Genes;Genetic Transcription;Genome;Histones;Human;Intercept;Intervention;Lead;Link;Metabolic;Metabolic Pathway;Metabolism;Modification;Molecular;Nature;novel;novel therapeutic intervention;Nuclear;Nuclear Receptors;permissiveness;Phosphotransferases;Post-Translational Protein Processing;programs;Proteins;repaired;Research;response;Shapes;Signal Pathway;Signal Transduction;tool

PROJECT_TITLE: Eavesdropping on the conversation between chromatin and metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Stress can be a risk factor that shifts alcohol consumption from recreational to excessive, and evidence supports an association between post-traumatic stress disorder (PTSD) and the development of an alcohol use disorder (AUD). We developed an animal model where repeated exposure to traumatic stress (a model of PTSD) significantly increased anxiety-related behavior and later alcohol drinking in male and female mice, with heterogeneity in the response as is seen in PTSD patients. We will use this model to determine sex differences in biological and molecular mechanisms that confer susceptibility for increased drinking following traumatic stress so that the information can guide the development of new interventions for the treatment of PTSD- induced AUD, which likely differ in males and females.

PI_NAMEs: RYABININ, ANDREY E (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;antagonist;Anxiety;anxiety-related behavior;Behavioral;Biological;Brain region;Classification;Clozapine;comorbidity;CRF receptor type 1;designer receptors exclusively activated by designer drugs;Development;Disease;drinking;epidemiology study;Ethanol;Euthanasia;Exposure to;Female;FOS gene;Genetic;Heart Rate;Heterogeneity;Hippocampus;Immunohistochemistry;Incidence;Individual;Intake;Intervention;male;Maps;Medial;Modeling;Molecular;Mus;Neurons;Odors;Oxides;Patients;Pattern;pharmacologic;Pharmacology Study;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;Prevalence;prevent;Proteins;Recovery;Recreation;Reporting;resilience;response;Risk Factors;Rodent;Role;Sex Differences;Signal Transduction;Stress;stressor;Symptoms;targeted treatment;Testing;therapy development;Trauma;traumatic stress;Water;women versus men;Women's prevalence

PROJECT_TITLE: Sensitivity and resilience to increased alcohol drinking in males and females following traumatic stress

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative We propose to build resources to support cancer immunotherapy, by establishing essential software tools and generating data critically missing at present for canine histocompatibility complex class I (MHC-I) genotyping and tumor-specific neoantigen (TSNA) discovery. Our proposed research will significantly enhance the applicability of the dog model for translational research.

PI_NAMEs: HILDEBRAND, WILLIAM ;ZHAO, SHAYING  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Algorithms;Alleles;artificial neural network;Base Pairing;Behavior;Binding;Breeding;cancer immunotherapy;cancer prevention;cancer therapy;canine model;Canis familiaris;Cell Culture Techniques;Cell Line;Cells;Clinical;Clinical Data;Clinical Trials;Collaborations;Data;Data Analyses;Data Commons;data resource;Databases;Development;Etiology;exome sequencing;experience;Funding;Genome;genome sequencing;Genotype;Heterogeneity;Human;human genomics;Immune system;immunogenicity;immunotherapy trials;Major Histocompatibility Complex;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Modeling;Molecular;mutant;National Cancer Institute;neoantigens;Neural Network Simulation;next generation sequencing;Oncology;Outcome;Peptides;Population;pre-clinical;Pre-Clinical Model;predictive tools;prevent;Procedures;Proteins;Publishing;Quality Control;Research;Resources;Rodent Model;Sampling;Sequence Read Archive;software development;Software Tools;Structure;success;Time;tool;Training;transcriptome;transcriptome sequencing;Translating;Translational Research;treatment and outcome;tumor;Vaccination;Validation;whole genome;Work

PROJECT_TITLE: Canine MHC-I genotyping and tumor specific neoantigen determination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]