NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Down Syndrome;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;Applications Grants;Area;Basic Science;Cell Nucleus;Clinic;Clinical;clinical application;Clinical Services;collaborative approach;Communities;Community Outreach;community partnership;community setting;Complement;Consultations;cost effective;Creativeness;Department chair;design;Discipline;Down's Syndrome;Environment;Equipment;Event;Faculty;Family;Feedback;Foundations;functional genomics;Funding;genome editing;Genomic medicine;Goals;Graduate Education;Health Services;Healthcare Systems;human genomics;human pluripotent stem cell;Humpback Dolphins;improved;Individual;information gathering;Intellectual and Developmental Disabilities Research Centers;interdisciplinary collaboration;interest;International;Knowledge;Leadership;lectures;meetings;Newsletter;novel;outreach;Parents;patient advocacy group;Patients;Phase;precision medicine;Primates;Privatization;Program Development;Publications;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Scientist;Series;Services;social media;special interest group;Support Groups;Surveys;Training;Translational Research;United States National Institutes of Health;Universities;Vision;Visit;Wisconsin;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Signaling pathways driven by the signaling lipid phosphoinositides (PIs) are frequently altered in many human diseases while the contributions of nuclear PIs found in the non-membranous subnuclear compartments to human health remain still largely elusive since the initial discoveries in the 1950s. With innovative research tools and genome-wide studies, we will elucidate the nature and functions of nuclear PIs in the regulation of key nuclear processes such as transcription control and epigenetics within diverse cellular contexts. The completion of the proposed research programs will provide fundamental knowledge for understanding the importance of nuclear PIs in human pathophysiology.

PI_NAMEs: CHOI, SUYONG  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Autoimmunity;Belief;Biochemical;Biological;Cell Nucleus;Cell Physiology;Cells;Chromatin;cohort;Complex;Cytoskeleton;DNA Double Strand Break;DNA Repair;Ensure;Enzymes;Epigenetic Process;Functional disorder;Gene Expression;Generations;genetic corepressor;genome-wide;genome-wide analysis;Goals;Health;high resolution imaging;Human;human disease;innovation;insight;Knowledge;Link;Lipids;Malignant Neoplasms;Mediating;Metabolic Diseases;Microscopic;Minor;Molecular;Nature;Neurodegenerative Disorders;novel;novel strategies;Nuclear;Pathogenesis;Phosphatidylinositols;Phospholipids;Phosphotransferases;Positioning Attribute;Process;programs;Proteins;Proteomics;recruit;Regulation;Repression;Research;RNA Processing;Role;Signal Pathway;Signal Transduction;spatiotemporal;Stimulus;tool;trafficking;Transcription Coactivator;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Unexpected roles of phosphoinositides in the nucleus

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Telomere maintenance by telomerase is a critical pathway for tissue homeostasis in the human body and as a consequence, deficiencies in telomerase lead to premature aging diseases and inappropriate activation of telomerase is a hallmark of 90% of human cancers. Telomerase is a multi-component ribonucleoprotein and its assembly is deficient in premature aging disorders and could be targeted to inhibit telomerase activity in cancer cells. The goal of this study is to determine the molecular mechanism underlying the role of TCAB1, an RNA- binding protein essential for telomere maintenance, in telomerase assembly to develop new approaches to target telomerase function for therapeutic purposes.

PI_NAMEs: SCHMIDT, JENS CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;aging related disease;Apoptosis;Automobile Driving;Biochemical;Biological;cancer cell;cancer therapy;Cell Nucleolus;Cell Physiology;Cells;Charge;chromosome replication;Chromosomes;cofactor;Complex;Critical Pathways;Defect;Development;Disease;DNA;DNA Sequence;driving force;Dyskeratosis Congenita;Exclusion;experimental study;Goals;Homeostasis;Human;Human body;Human Chromosomes;In Vitro;Interdisciplinary Study;Label;Laboratories;Lead;Liquid substance;Malignant Neoplasms;Methods;Modeling;Molecular;molecular imaging;N-terminal;novel strategies;Nuclear;Nucleic Acids;Organelles;Patients;Peptides;Phase;Physical condensation;Physiological;premature;Premature aging syndrome;Proliferating;Property;Proteins;recruit;Regulation;Ribonucleoproteins;RNA Folding;RNA-Binding Proteins;RNA-Directed DNA Polymerase;Role;single molecule;stem cell exhaustion;stem cell population;stem cell proliferation;stem cells;targeted treatment;Telomerase;Telomerase inhibition;Telomerase RNA Component;telomere;Telomere Maintenance;Telomere Shortening;Testing;Therapeutic;therapy development;Time;Tissues;tool;trafficking;Transcriptase;tumor;WD Repeat;Work

PROJECT_TITLE: Defining the role of TCAB1 and its phase separation in telomerase assembly.

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Transgender and other gender minority emerging adults are at greater risk for substance use and adverse mental health outcomes than their non-transgender peers, driven in part by social stressors (e.g., stigma) and sociocultural appearance pressures. Online, interactive media (e.g., social media) may be a significant source of social stressors and harmful appearance pressures, while also offering unprecedented access to support for gender minority emerging adults and novel opportunities for interventions to reduce body dissatisfaction and substance use. This research will increase knowledge about (a) the influence of social media environments on body dissatisfaction and other substance use risk factors and (b) the feasibility and acceptability of an innovative intervention to increase critical social media literacy and reduce substance use risk factors with the goal of improving the health and wellbeing of gender minority young people and advancing health equity.

PI_NAMEs: GORDON, ALLEGRA RABOFF (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;Access to Information;Address;Adult;Age;age group;Alcohols;Appearance;arm;Award;Behavior;Behavior Therapy;Behavioral;biological adaptation to stress;Birth;body dissatisfaction;Boston;brief intervention;career development;cigarette smoking;cisgender;cohort;community advisory board;community engaged research;community engagement process;critical developmental period;design;Development;diaries;Disparity;Eating Disorders;effective intervention;emerging adult;emerging adulthood;Environment;experience;Exposure to;Face;Family;Feasibility Studies;feasibility testing;Feeling suicidal;Female;Feminine;follow up assessment;Future;gender affirmation;Gender Identity;gender minority;gender minority group;gender nonconforming;Goals;harassment;Health;Health behavior;health equity;health inequalities;high risk drinking;illicit drug use;improved;Individual;innovation;Instagram;Intervention;Intervention Studies;Interview;Knowledge;Link;literacy;male;Marketing;Masculine;Media Intervention;media use;Mediating;men;Mental Health;minority children;minority stress;Modeling;nonbinary;novel;Outcome;Participant;peer;Personal Satisfaction;Persons;Phase;Physiological;Policies;Population;post intervention;pressure;prevent;Prevention;preventive intervention;primary outcome;programs;protective factors;psychologic;psychological distress;Quasi-experiment;reduced substance use;Research;Research Methodology;resilience;resilience factor;Resistance;Resources;response;Risk;Risk Factors;Role;Sampling;Schools;Scientist;secondary outcome;sex assigned;Sexual and Gender Minorities;skills;social culture;Social Environment;social influence;social media;social stigma;social stressor;Social support;Source;Stigmatization;Strategic Planning;stressor;substance use;substance use prevention;Surveys;Symptoms;Technology;Testing;theories;therapy development;Tobacco Industry;Training;Transact;transgender;Underserved Population;United States National Institutes of Health;usability;web-based intervention;Woman;Work;young adult

PROJECT_TITLE: Social Media and Substance Use Risk and Resilience Among Gender Minority Emerging Adults

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: DAWALT, LEANN SMITH (contact)

PROJECT_TERMS: Address;Adult;Area;autism spectrum disorder;Basic Science;behavior test;Behavioral;biobank;biobehavior;Biomanufacturing;Biomedical Research;Blindness;Cell Therapy;Child;Clinic;Clinical;Clinical assessments;Clinical Data;Clinical Research;Clinical Services;clinical translation;Clinical Trials;cohort;Communities;Community Practice;computerized data processing;Consent;Consultations;cost effective;COVID-19;Custom;Cyclic GMP;Data;Data Collection;Databases;design;Development;Developmental Disabilities;Diagnostic;disability;DNA;Down's Syndrome;early childhood;Electronic Health Record;Enrollment;Equipment;Evaluation;Experimental Designs;Fragile X Syndrome;Future;Health;Health system;Hospitals;Human;Individual;individuals with autism spectrum disorder;Infant;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention;laboratory equipment;Measurement;method development;Modeling;new technology;Nursery Schools;Participant;Phenotype;Plasmids;Population;Process;programs;Proteins;psychologic;Recontacts;Recording of previous events;recruit;Registries;Research;Research Personnel;Research Proposals;Resources;response;Services;software development;Specimen;Supervision;Technology;therapy development;Training;Translational Research;Translations;Traumatic Brain Injury;Universities;Video Recording;virtual;Virus;visual tracking

PROJECT_TITLE: Clinical Translational Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: CHEMISTRY

PHR: Project Narrative We propose to investigate the importance and origin of a fascinating modification that we recently discovered to the HIV structural proteins, namely the formation of dehydroamino acids. HIV is the virus that causes AIDS and infects over 1 million people each year. We will examine the role of these modifications in the HIV life cycle and evaluate their purpose. Further, we will test the hypothesis that they are formed enzymatically, and if so, discover the enzyme responsible. This may provide an exciting new pathway for the development of antiretroviral therapeutics. In 2020, over 37 million people, including 1.7 million children, were living with the virus, and over 500,000 died from AIDS. For a robust eradication of the virus, additional research such as the work proposed here is desperately needed to eliminate knowledge gaps in our understanding of viral infection and replication.

PI_NAMEs: SHERER, NATHAN M;SMITH, LLOYD M (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: 3-Dimensional;Acids;Acquired Immunodeficiency Syndrome;Amino Acids;Anti-Retroviral Agents;Biological;Biological Assay;Biology;candidate identification;Capsid;Cells;Chemicals;Child;Complex;crosslink;cycloaddition;Cysteine;Data;dehydroalanine;dehydrobutyrine;Development;Enzymes;fascinate;Glutathione;High Prevalence;Histidine;HIV;HIV Infections;HIV-1;HIV-1 protease;Human;Hydrogenation;in vitro activity;in vivo;Individual;innovation;insight;knock-down;Knowledge;Life Cycle Stages;Literature;Lyase;Lysine;Mass Spectrum Analysis;matrix protein, Human immunodeficiency virus type 1;Measures;Modeling;Modification;Molecular Conformation;Mutagenesis;Mutate;Mutation;novel therapeutics;Output;overexpression;Pathway interactions;Peptides;Persons;pi bond;Play;Post-Translational Protein Processing;Process;Production;Property;protein crosslink;Proteins;Proteome;Proteomics;Reaction;Research;Role;Sampling;screening;Serine;Site;Site-Directed Mutagenesis;Small Interfering RNA;Structural Protein;Suppressor Mutations;Testing;Therapeutic;Threonine;transcriptomics;Viral;Viral Proteins;Virion;Virus;Virus Diseases;Virus Inactivation;Virus Replication;Work

PROJECT_TITLE: Dehydroamino acids in HIV-1 capsid and matrix proteins:  new potential targets for viral inactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Difficulties in how people respond to negative and positive outcomes (called `valuation') in our environment can be related to debilitating depression and anxiety. Here we use novel neuroscience and computational methods to study how links among depressed mood, anhedonia, anxiety, and different types of valuation vary over time and can be changed. This work may lead to new ways to understand the role of valuation in mental health and neuroscience-guided behavioral approaches for treating symptoms regardless of mental health diagnosis.

PI_NAMEs: CHIU, PEARL H (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Anhedonia;Anxiety;arm;Bayesian Modeling;Behavioral;Categories;Characteristics;Clinical;Clinical Data;clinically relevant;clinically significant;Cognitive Therapy;Computer Models;Computing Methodologies;Coupled;Data;Depressed mood;Development;Diagnosis;Diagnostic;Dimensions;Disease;Elements;Ensure;Environment;Image;improved;Individual;Learning;Link;machine learning classification;Manuals;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Modeling;Moods;National Institute of Mental Health;negative mood;Negative Valence;neurobehavioral;neuroimaging;Neurosciences;novel;Outcome;Participant;Persons;Positioning Attribute;Positive Valence;Process;Protocols documentation;Psychiatry;Psychopathology;Randomized;Research Domain Criteria;Rewards;Role;Sampling;Scientist;Specificity;Structure;symptom treatment;Symptoms;Task Performances;Techniques;Testing;Time;trait;Translating;Validation;Visit;Work

PROJECT_TITLE: Evaluating overlap and distinctiveness in neurocomputational loss and reward elements of the RDoC matrix


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: DERMATOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE In this proposal, we propose to study the involvement of PCSK9, a critical protein that regulates the body’s cholesterol levels, for its involvement in modulating the anti-tumor immune response after radiotherapy. In particular, we will study the interaction between PCSK9 and the cGAS-STING pathway during radiotherapy and immune checkpoint blockade therapy of local and distant tumors. Because PCSK9 inhibitors are already available clinically for the treatment of hyperlipidemia, our study may lead to future clinical trials evaluating PCSK9 inhibitors for their ability to improve radiotherapy and immunotherapy of locoregional and distant tumors.

PI_NAMEs: ANTONIA, SCOTT J.;LI, FANG ;ZHANG, JENNIFER YUNYAN  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: anti-tumor immune response;Antibodies;Antitumor Response;base;Binding;Blood;cancer therapy;cell killing;checkpoint therapy;Cholesterol;Clinical;Clinical Treatment;Clinical Trials;Combined Modality Therapy;CRISPR/Cas technology;Cytoplasm;Data;Distant;DNA Damage;ds-DNA;Effector Cell;efficacy evaluation;Extravasation;Future;genetic approach;Genomic DNA;Goals;Histocompatibility Antigens Class I;Hyperlipidemia;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunologic Stimulation;Immunotherapy;immunotherapy clinical trials;Implant;improved;inhibitor;inhibitor therapy;insight;Interferon Type I;Irradiated tumor;Knockout Mice;Local Therapy;Lymphocytic Infiltrate;Mediating;MHC Class I Genes;Modeling;Molecular;molecular targeted therapies;Monoclonal Antibodies;Mus;mutant;Nature;Neoplasm Transplantation;neoplastic cell;novel;Nuclear;Outcome;Pathway interactions;Play;pre-clinical;protein expression;Proteins;Publishing;Radiation;radiation effect;Radiation induced damage;Radiation Induced DNA Damage;Radiation therapy;Radiobiology;Reporting;response;restraint;Role;Signal Pathway;Signal Transduction;Site;Stimulator of Interferon Genes;STING agonists;STK11 gene;Stromal Cells;subcutaneous;Surface;synergism;T-Cell Activation;T-Lymphocyte;Targeted Radiotherapy;Therapy Clinical Trials;Transplantation;Treatment Efficacy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Comparative Effectiveness Research;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Improving patient outcomes will be enhanced by understanding “what works, for whom?” enabling better matching of patients to available treatments. This project will use individual participant data from 27 clinical trials and data from two clinical populations to determine which treatments work best for various subsets of patients.

PI_NAMEs: BARKER, DAVID HEATON;BENITO, KRISTEN G (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Age;analytical tool;Apple;Behavior Therapy;burden of illness;Caregivers;Characteristics;Child;Childhood;Clinical;Clinical Data;Clinical Trials;Cognitive;Cognitive Therapy;comorbidity;comparative effectiveness;compare effectiveness;comparison intervention;Data;data archive;Development;Dose;Education;Emotional;ethnic minority population;Evaluation;Evidence based intervention;Family;Family psychotherapy;Foundations;Head;Hospitals;improved;Individual;Infrastructure;insight;International;Intervention;Leadership;Length;Measures;member;Meta-Analysis;Methods;Modality;Modification;National Institute of Mental Health;Obsessive-Compulsive Disorder;Outcome;outpatient programs;Participant;Patient advocacy;patient subsets;Patient-Focused Outcomes;Patients;Population;Prevention;Principal Investigator;Process;programs;racial minority population;randomized trial;Recording of previous events;reduce symptoms;Relaxation;Research;response;Sample Size;Sampling;Schedule;Severities;Severity of illness;social;Statistical Models;Subgroup;Symptoms;Target Populations;Testing;therapy outcome;Time;Transportation;treatment comparison;Treatment Effectiveness;Treatment Efficacy;treatment response;usability;Variant;Work

PROJECT_TITLE: What works for Whom in Pediatric OCD

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: ALEXANDER, ANDREW L (contact)

PROJECT_TERMS: Acclimatization;animal imaging;Animal Model;anxiety reduction;base;Behavioral;behavioral phenotyping;Blood flow;Brain;Brain imaging;Cerebrum;Communities;computer science;Computer software;Computer Systems;Consultations;Data;data acquisition;Data Analytics;Data Storage and Retrieval;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Educational workshop;Energy Metabolism;Ensure;Environment;Exhibits;Experimental Designs;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Goals;High Performance Computing;Human;human model;Image;Image Analysis;image processing;imaging modality;imaging scientist;Individual;Infrastructure;insight;instrument;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;meetings;Methodology;Methods;Modality;Molecular;Morphologic artifacts;Motion;MRI Scans;Nerve Degeneration;neural;neural correlate;neural patterning;neurochemistry;neurodevelopment;neuroimaging;neuropathology;Neurosciences;Neurotransmitters;nonhuman primate;novel;novel marker;Participant;Performance;Perfusion;Physics;Physiologic pulse;Physiological;Physiology;Population;Positron-Emission Tomography;Procedures;protocol development;Protocols documentation;Quality Control;Radiopharmaceuticals;radiotracer;Research;Research Personnel;Research Project Grants;Resolution;Resources;Rest;Risk;Rodent;Scanning;Scientist;Sensory Receptors;Services;skills;Software Tools;Spectrum Analysis;Statistical Data Interpretation;statistics;Structure;Students;System;Talents;Technical Expertise;Technology;tool;Training;Update;white matter

PROJECT_TITLE: Brain Imaging Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Although the ability to vicariously experience the other's aversive feelings in a situation, a process called observational fear (OF), is critical to live in society and the malfunctions of OF represent well-described findings in individuals with autism spectrum disorders, it remains unknown about the neural mechanisms of how both prior similar own fear experience and social familiarity with demonstrator facilitate OF (experience- dependent OF). Our proposed studies will elucidate the neural circuit mechanisms of the experience- dependent OF by examining hippocampal-amygdala neural circuits. Our proposed study will uncover the neural substrates for the fear memory ensemble-dependent perception-action mechanisms as a principle of Exp OF, which may be potentially generalized for other types of empathic ability.

PI_NAMEs: KITAMURA, TAKASHI  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;Anterior;Behavior;Cells;cingulate cortex;Communication;Data;Dorsal;dorsal visual stream;Empathy;experience;Familiarity;fear memory;Feeling;field study;Fright;Gene Expression;Generations;Genetic;Goals;Hippocampus;Immediate-Early Genes;in vivo calcium imaging;individuals with autism spectrum disorder;Mediating;Memory;Modeling;Mus;Nature;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;Pathway interactions;Perception;Population;Process;Reaction;Research;Role;Shock;social;Societies;Testing

PROJECT_TITLE: Neural circuit mechanisms for experience-dependent observational fear


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SVAREN, JOHN P (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Basic Science;behavior test;Behavioral;behavioral phenotyping;Biological Markers;Biotechnology;Brain;Cell Culture Techniques;cell type;Cells;Cellular biology;Coculture Techniques;Cognition;Cognitive;Complex;Comprehensive Cancer Center;Defect;design;Development;Diagnosis;Dimensions;Disease;disease mechanisms study;disease phenotype;Electrophysiology (science);empowerment;Ensure;Epigenetic Process;epigenomics;experimental study;Fostering;Generations;Genes;Genetic;genome editing;Genomics;Goals;Human;human embryonic stem cell;human induced pluripotent stem cells;human pluripotent stem cell;Human Resources;human stem cells;Image;Individual;induced pluripotent stem cell;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;International;Investments;Libraries;meetings;Methods;Microscopy;model organism;Modeling;Modification;Molecular;Molecular Analysis;Molecular Biology;multilevel analysis;Mus;Mutation;Nervous System;nervous system development;Nervous System Physiology;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;Neurosciences;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Pathway interactions;Patients;peer;Pharmaceutical Preparations;Phenotype;Physiology;preclinical study;Rattus;Reproducibility;Research;Research Personnel;Resources;Rodent;Rodent Model;Science;screening;Service delivery model;Services;Signal Transduction;Site;skills;small molecule;stem cell model;Structure;Study models;Supervision;Systems Analysis;Techniques;Technology;testing services;therapeutic candidate;Tissues;tool;Training;translational approach;translational model;Translational Research;translational study

PROJECT_TITLE: IDD Models Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Obesity and related health problems are an accelerating national health problem. We recently discovered a new circulating hormone, asprosin, that precisely controls appetite levels, and antibodies that neutralize it improve obesity in mice. The proposal represents an effort to validate the CNS receptor for asprosin that was recently discovered by our laboratory, and its potential targeting for treatment of obesity and the underlying mechanisms.

PI_NAMEs: CHOPRA, ATUL  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Adult;Anti-Obesity Agents;Antibodies;Appetite Stimulants;Automobile Driving;Binding;Blood Glucose;blood-brain barrier crossing;Body Weight;Brain;brain tissue;Cell Surface Receptors;Chimeric Proteins;Circulation;Desire for food;disease model;Eating;Event;extracellular;Fasting;gamma-Aminobutyric Acid;Genetic;glucose production;Health;Hepatic;Hormones;Human;Impairment;improved;in vivo;increased appetite;Insulin;Knowledge;Laboratories;Leptin;Ligand Binding;Ligand Binding Domain;Liver;Mass Spectrum Analysis;Mediating;Metabolic dysfunction;Metabolic syndrome;Molecular;Monoclonal Antibodies;mouse model;Mus;Mutation;neural;Neurons;neutralizing antibody;novel therapeutics;Obese Mice;Obesity;obesity treatment;Pathologic;Pathway interactions;pharmacologic;Phenocopy;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Plasma;Protein Tyrosine Phosphatase;receptor;reduced food intake;Signal Transduction;Testing;Therapeutic;Thinness;transcription factor;weight maintenance;Wiedemann-Rautenstrauch syndrome

PROJECT_TITLE: The CNS Receptor For Asprosin

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Type III interferons (IFNλ) responses play opposing roles in protecting or enhancing intestinal damage upon inflammatory injury. The overarching goal of this research program is to mechanistically define signal integration and cell identity contribute to these opposing roles.

PI_NAMEs: FORERO, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: cell type;Cells;Cellular Stress;Chromatin Remodeling Factor;cytokine;Epithelium;Equilibrium;Event;Future;Genes;Genetic;Goals;Inflammatory;Inflammatory Response;Injury;interdisciplinary approach;Interferon Type II;Interferons;Intestines;Knowledge;MAP Kinase Gene;NF-kappa B;novel;Pathway interactions;Play;Predisposition;preservation;programs;receptor;Regulatory Pathway;repaired;Research;response;Role;Signal Transduction;Specific qualifier value;STAT protein;therapeutic development;Therapeutic Intervention;Tissues;transcription factor;Viral;viral detection;Viral Physiology;Virus Diseases;Work

PROJECT_TITLE: Identification of novel type III IFN regulatory pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Human Genome;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Whereas advances in cancer treatment have dramatically improved the survival of cancer patients, some cancer patients suffer from serious side effects of cancer treatments, a typical example of which is the heart-muscle damage caused by anthracyclines, one of the most common chemotherapy drugs used for leukemia, breast cancer, and childhood cancer. Currently, it is challenging to predict who will develop heart problems before using anti-cancer drugs and prevent their side effects on the heart. To address these problems, this project aims to generate a “risk scoring system” to evaluate the risk of chemotherapy-induced heart damage from patients’ genetic information and identify already-existing drugs that could prevent the heart damage using human induced pluripotent stem cells (iPSCs) and cutting-edge CRISPR technologies.

PI_NAMEs: NISHIGA, MASATAKA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adherent Culture;Affect;Age;angiogenesis;Anthracycline;Antineoplastic Agents;base;base editor;Biological;Biomedical Engineering;Blood Pressure;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;Candidate Disease Gene;Cardiac;cardioprotection;Cardiotoxicity;Cardiovascular system;career development;cell type;Cells;Characteristics;Chemicals;chemotherapy;Clinical;clinical application;Clinical Research;ClinVar;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;CRISPR/Cas technology;Data Set;DNA Damage;Dose;Doxorubicin;Drug Targeting;Drug usage;Echocardiography;Electrophysiology (science);Endothelial Cells;Engineering;Etiology;Evaluation;experimental study;Extracellular Matrix;Feedback;Fibroblasts;Gender;Gene Expression;Genes;genetic information;genetic makeup;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome wide screen;genome-wide;Genomics;Goals;Heart;heart damage;Heart failure;heart metabolism;Histology;HTATIP gene;human induced pluripotent stem cells;Immunology;Impairment;improved;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;inhibitor therapy;International;leukemia;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Mechanics;Mentors;Mitochondria;Modeling;mouse model;Multiomic Data;Mus;Myocardium;Oncology;Oxidative Stress;paracrine;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;Phase;Phenotype;Phosphotransferases;Predisposition;prevent;prime editing;prime editor;Production;programs;protective effect;Qi;Radiation therapy;Research;Risk;Risk Assessment;Risk Factors;risk stratification;scale up;screening;side effect;Signal Transduction;single-cell RNA sequencing;skills;Stretching;Supervision;System;Technology;Testing;therapeutic target;Tissue Engineering;Tissue Model;Tissues;Training;Tyrosine Kinase Inhibitor;Validation;Variant

PROJECT_TITLE: Parallel Characterization of Genetic Variants in Chemotherapy-Induced Cardiotoxicity Using iPSCs

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Skin Cancer

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative Mohs micrographic surgery is a highly effective procedure to selectively remove skin tumors; however, it is used in only a fraction of skin tumor surgeries because it requires substantial infrastructure and personnel training. This proposal seeks to develop lower infrastructure methods to assess surgical success during skin tumor surgery with the long term vision to expand surgical guidance where it is indicated but not currently being used.

PI_NAMEs: TUNNELL, JAMES W (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adopted;Adoption;Algorithms;Basal cell carcinoma;Biochemical;Caring;Classification;Clinical;Clinical assessments;confocal imaging;Confocal Microscopy;Data;Data Set;Decision Support Systems;Dermatologist;design;Detection;Development;Diagnosis;diagnostic accuracy;diagnostic tool;Disparity;effective therapy;ex vivo imaging;Excision;Fluorescence;Frozen Sections;Future;Goals;Health Services Accessibility;Histopathology;Human;Human Resources;Image;Individual;Infrastructure;innovation;instrument;Machine Learning;machine learning method;Methods;micrography;Microscope;microscopic imaging;Modality;Modeling;Mohs Surgery;Molecular;multimodality;Operative Surgical Procedures;Optics;Outcome;Pathologist;Patients;Performance;Population;predictive modeling;Procedures;Process;Prospective Studies;Raman Spectrum Analysis;Rural;Sampling;Scanning;Skin;Skin Cancer;Skin Carcinoma;Skin Neoplasms;Specificity;Speed;Structure;success;Surgical margins;Testing;Time;tissue processing;Tissues;Training;tumor;Underserved Population

PROJECT_TITLE: Multimodal confocal microscopy for surgical guidance of skin resections

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: TRAVERS, BRITTANY GAIL (contact)

PROJECT_TERMS: 7 year old;Address;Age;Attention deficit hyperactivity disorder;Autism Diagnosis;autism spectrum disorder;autistic children;Behavior;behavior observation;behavior prediction;Behavioral;Behavioral Assay;Biological Assay;Biology;biomarker development;Brain;Brain imaging;Brain scan;Cell Line;Child;Clinic;Clinical;clinical translation;cloud based;cognitive function;cohort;comorbidity;Data;Development;Developmental Course;Developmental Disabilities;Diagnosis;Disease;early childhood;Early Diagnosis;early screening;Electrophysiology (science);Elements;Etiology;evidence base;Exhibits;functional genomics;Future;Gene Expression;gene network;gene regulatory network;Generations;Genes;Genetic;genetic architecture;genome wide association study;Genomic Segment;Genomics;Genotype;Goals;Head;Heritability;Human;human stem cells;Image;imaging modality;Impairment;improved;Individual;Individual Differences;individuals with autism spectrum disorder;induced pluripotent stem cell;Infrastructure;innovation;insight;Intellectual and Developmental Disabilities Research Centers;Intervention;Knowledge;lens;Link;longitudinal design;Machine Learning;machine learning model;machine learning prediction;Mental disorders;Modality;model of autism spectrum disorder;Modeling;Molecular;Molecular Profiling;Morphologic artifacts;Morphology;Motion;multidisciplinary;multimodal data;multimodality;multiple data types;National Institute of Mental Health;nerve stem cell;neural;neurobehavior;neurobehavioral;Neurodevelopmental Disorder;neuroimaging;Neuronal Differentiation;Neurons;neuropsychiatric disorder;novel;Participant;Patients;Phenotype;pluripotent stem cell differentiation;Population;prospective;psychosocial;recruit;Research;Resources;Risk;Sampling;Scanning;SNP array;social;Specific qualifier value;Statistical Methods;stem cells;structural imaging;Symptoms;Testing;Time;transcriptomics;Work

PROJECT_TITLE: How Children with ASD Develop ADHD over Time: An Integrated Analysis through the Lenses of Functional Genomics, Stem Cells, Brain Imaging, and Neurobehavior


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Diabetes

ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE  Diabetes and its complications are a critical and growing public health problem in the United States and abroad. Given the complexity of this disease and associated syndromes, it is essential to recruit dedicated and talented researchers into the diabetes and metabolism field, and train them in interdisciplinary approaches. The Joslin Diabetes Center T32 Training Program in Diabetes and Metabolism aims to attract outstanding young scientists and physician/scientists into diabetes and metabolism research, and train them in a rich, vibrant, inclusive, diverse, and collaborative environment in which they are exposed to the many facets of diabetes, its underlying causes, and its complications.

PI_NAMEs: BLACKWELL, T KEITH (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Training Grant in Diabetes and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Prevention;Substance Misuse;Tobacco

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: NARRATIVE. Tobacco use is the leading cause of preventable death in the United States. This application will determine for the first time how visinin-like protein-1 (an endogenous protein found in the brain) modulates the function and expression of the most abundant neuronally-expressed nicotinic receptor subtype, which is well known to play a pivotal role in nicotine use disorder. By addressing critical gaps in our knowledge, this research will 1) advance the scientific understanding of intrinsic control mechanisms regulating nicotinic receptor function and expression, and 2) may provide an essential foundation for the development of new therapies to promote nicotine use cessation.

PI_NAMEs: WELTZIN, MAEGAN M (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Accounting;Address;Adult;Affect;Agonist;Alaska;Alzheimer's Disease;aspirate;Attenuated;Behavior;Binding;Binding Sites;Biological Assay;Brain;career;Cell membrane;Cell surface;Cells;Central Nervous System;Cessation of life;cholinergic;Cholinergic Receptors;Chronic;cigarette smoking;Clinical;Confocal Microscopy;Data;Development;Dopamine;Drug Design;drug development;Electrophysiology (science);Environment;Epilepsy;Extramural Activities;Faculty;follow-up;Foundations;Funding;Future;Generations;Goals;hands on research;Homeostasis;improved;Individual;Institution;Ion Channel Gating;Knowledge;Letters;Ligands;Mediating;Mentors;Mentorship;Mission;Molecular Chaperones;Mutate;National Institute of Drug Abuse;neurobiological mechanism;Neurons;Nicotine;nicotine cessation;nicotine reward;nicotine use;Nicotine Use Disorder;Nicotinic Agonists;Nicotinic Receptors;novel;novel strategies;novel therapeutics;Pathway interactions;Pharmacologic Substance;Pharmacology;Physiology;Plasma Enhancement;Play;Population;Positive Reinforcements;preventable death;Prevention;Protein Isoforms;protein phosphatase inhibitor-2;Proteins;Publications;Publishing;receptor;receptor expression;receptor function;Regulation;Relapse;Research;Research Personnel;Research Support;Resources;Rewards;Role;Schizophrenia;Science;Scientific Advances and Accomplishments;Signal Transduction;Site;small molecule;smoking cessation;stoichiometry;Students;success;Techniques;Time;timeline;tobacco products;Tobacco smoke;Tobacco use;tobacco user;Underrepresented Students;United States;Universities;visinin;Work;World Health Organization

PROJECT_TITLE: Visinin-like protein-1 modulation of nicotinic receptors


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Training the future leaders of gastroenterology requires a broad multidisciplinary approach. This training program is built around the philosophy that the future of academic gastroenterology requires nurturing and dedicated training for predoctoral scientists, research-oriented physicians and physician-scientists who will exploit opportunities in basic, translational and clinical research, including health services and public health research.

PI_NAMEs: DAVIDSON, NICHOLAS O. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Clinical/Laboratory Training Academic Gastroenterology


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Despite the effectiveness of antiretroviral medications for HIV suppression, people with HIV who also have mental health and or substance use disorders suffer disparities in rates of HIV suppression and retention in HIV care and thus have potential to sustain the HIV epidemic. We propose to evaluate effectiveness while also gathering implementation data on an innovative adaptation of collaborative care, using trained peer-specialists as care managers in a team based approach to increasing engagement in mental health and substance use disorder care in HIV continuity care settings; which will then lead to increases in HIV viral suppression and care retention. This proposal has potential to advance the implementation science of mental health and substance use disorder care integration into HIV care settings thus advancing progress towards ending the HIV epidemic

PI_NAMEs: FALADE-NWULIA, OLUWASEUN  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: addiction;Adoption;Alcohol abuse;alcohol use disorder;Anti-Retroviral Agents;arm;Baltimore;behavioral health;care providers;Caring;Case Manager;Characteristics;Clinic;Clinical;Clinical Data;clinical decision-making;collaborative care;computerized;Continuity of Patient Care;cost;Cost Analysis;Data;Disease;Disparity;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Epidemic;evidence base;Evidence based treatment;experience;Failure;Goals;Health;Health Personnel;heroin use;HIV;HIV Infections;Hybrids;implementation evaluation;implementation measures;implementation process;implementation science;implementation strategy;improved;Individual;innovation;Intervention;Interview;Knowledge;Maintenance;Measurement;Measures;Mediator;medical specialties;Medication Management;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;multidisciplinary;novel;opioid use disorder;Outcome;Outcome Measure;Patient Outcomes Assessments;patient population;Patients;peer;peer support;Persons;Pharmaceutical Preparations;Population;Prevalence;Primary Care;primary care provider;primary care setting;Process;programs;Provider;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;Questionnaires;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;RNA;screening;Self Administration;Self Management;Services;Severities;sociodemographics;Specialist;Structure;substance use;Substance Use Disorder;substance use treatment;Surveys;Symptoms;theories;Time;Training;treatment as usual;treatment program;Viral;Viral Load result

PROJECT_TITLE: Ending the HIV Epidemic: Peer-supported collaborative care for mental health and substance use disorder care integration into HIV care settings


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Aortic valve stenosis, a progressive disorder associated with calcification that worsens with aging, is the major cause of valve disease in the Western world, and the third leading cause of adult heart disease. Although there are no current medical therapies, we have discovered a small molecule drug that corrects dysregulated genes in patient valve cells and effectively treats aortic valve disease in mice. In this proposal, we will definitively determine the target of this drug, its optimal dose and route of administration, and associated pharmacologic properties and toxicity in order to advance for clinical development in patients with disease.

PI_NAMEs: SRIVASTAVA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Abnormal Cell;Adult;Age;Aging;Agonist;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;bicuspid aortic valve;Biological Availability;calcification;Cells;Characteristics;Childhood;Clinical;clinical development;clinical translation;comparative;Disease;disease model;dosage;Dose;Drug Delivery Systems;drug development;Drug Kinetics;Drug Targeting;early onset;efficacy evaluation;Eligibility Determination;Endothelial Cells;ERR1 protein;Estrogen Antagonists;estrogen-related receptor;Event;Family suidae;Future;gene correction;gene network;Genes;Genetic;Heart Diseases;human induced pluripotent stem cells;in vivo;Individual;induced pluripotent stem cell;inhibitor;Intervention;intraperitoneal;Laboratories;loss of function mutation;Loss of Heterozygosity;machine learning algorithm;Mechanics;Mediating;Medical;Modeling;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Network-based;NOTCH1 gene;Operative Surgical Procedures;Oral;Organ;Osteoblasts;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Population;Prevalence;prevent;Property;Receptor Inhibition;Reporting;Risk Factors;Route;small molecule;small molecule libraries;small molecule therapeutics;Stenosis;Testing;Therapeutic;therapeutic candidate;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;Toxic effect;translational study;United States;valve replacement;Western World

PROJECT_TITLE: Small molecule therapeutic for calcific aortic valve disease

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: SEATTLE

ORG_NAME: LAMPROGEN, INC.

ORG_STATE: WA

PHR: Project Narrative / Public Health Relevance Statement Personalized medicine requires technologies for measuring many disease biomarkers simultaneously for use in diagnostic tests; one widely used technology for clinical single-cell assays is flow cytometry, which is undergoing a transformation to greater multiplexing using a dramatically different technological approach called “spectral flow cytometry.” We have previously developed ultrabright high-multiplexing fluorescent probes called Pdots and have commercialized these Pdots for flow cytometry. Here we propose to expand our multi-color panel of Pdots to 75 for use in high multiplex spectral flow cytometry; this multi-color panel will also be useful in high multiplex tissue imaging (e.g., histopathology).

PI_NAMEs: YU, JIANGBO  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Antibodies;antibody conjugate;Autoimmune Diseases;B-Lymphocytes;Basic Science;Biological Markers;cancer therapy;CD8-Positive T-Lymphocytes;cell analyzer;Cell Cycle;Cells;Cellular Assay;Clinical;clinical diagnostics;Color;commercialization;Communicable Diseases;Compensation;Coupling;Dendritic Cells;design;detection platform;detector;Development;Diagnosis;diagnostic assay;diagnostic panel;Diagnostic tests;Disease;Dyes;Energy Transfer;Ensure;Exhibits;experimental study;Family;Fingerprint;Flow Cytometry;Fluorescent Dyes;Fluorescent Probes;Fluorochrome;fluorophore;Future;Histopathology;Human;Immune;Immune response;Immunophenotyping;improved;instrument;Label;Lasers;Mainstreaming;Malignant Neoplasms;Measures;Metabolic;Methods;monocyte;monomer;multiplexed imaging;nanoparticle;Natural Killer Cells;Nature;Optics;Pamphlets;Particle Size;peripheral blood;personalized medicine;Polymers;Population;preservation;Proteins;public health relevance;Quantum Dots;Reaction;Regulatory T-Lymphocyte;Research Personnel;Resolution;Series;Signal Transduction;Sorting;Source;System;T-Lymphocyte;Techniques;Technology;Time;Tissue imaging;Translational Research;ultraviolet;Validation;Vertebral column;Width

PROJECT_TITLE: An expanded 75-color panel of Pdots for spectral multiplexing


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Devastating mental health disorders, including schizophrenia and bipolar disorder, remain mysterious as to their underlying biological causes and potential treatments. This project aims to develop new tools based on cell types, connectivity, and manipulations of neural activity to study the structure and function of neural circuits during cognitive processing. We aim to expand an emerging field of mechanistic cognitive neuroscience to understand mental health, its disorders, and possible avenues for therapy from the basic building blocks of biological processes.

PI_NAMEs: HARVEY, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Animals;Area;Atlases;Behavior;Behavioral;Biological;Biological Process;Bipolar Disorder;Brain;Brain region;Calcium;cell type;Cells;Cellular Structures;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive process;cognitive task;Complex;computerized tools;Decision Making;Disease;Event;experience;experimental study;flexibility;Foundations;Goals;Image;Label;Link;Mental disorders;Mental Health;Methods;Modeling;Mus;neural;neural circuit;neural patterning;Neurobiology;Neurons;neurophysiology;Neurophysiology - biologic function;Neurosciences;optogenetics;Output;Pattern;Population;programs;Property;Research;Role;Schizophrenia;Shapes;spatiotemporal;Structure;Synapses;Testing;tool;Training;Viral;virtual environment;virtual reality system;Work;Writing

PROJECT_TITLE: Toward mechanistic cognitive neuroscience: cell types, connectivity, and patterned perturbations


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE CaMKII is an extremely abundant neuronal protein and a central mediator of the strengthening and weakening of neuronal synapses, termed bidirectional synaptic plasticity. This proposal will determine how the unique three- dimensional structure of CaMKII enables its dual role in these two opposing plasticity modes. The results from these experiments will provide critical insight into the normal role of CaMKII in synaptic plasticity and will in turn inform studies of CaMKII dysregulation in models of neurodegenerative, neurological, and neuropsychiatric disease.

PI_NAMEs: BROWN, CAROLYN NICOLE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Affinity;Avidity;Binding;Biochemical;Biochemistry;Biophysics;Calmodulin;calmodulin-dependent protein kinase II;Cells;Cognition;cognitive function;Complex;Data;Development;dimer;Disease;Excitatory Synapse;experimental study;Fluorescence;Frequencies;Geometry;Hippocampus;Holoenzymes;Impairment;In Vitro;Individual;insight;Learning;Long-Term Potentiation;Mediating;Mediator;Memory;Mental Depression;Modeling;Molecular;Molecular Computations;monomer;mutant;Mutate;N-Methyl-D-Aspartate Receptors;Negative Staining;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;Phosphotransferases;Positioning Attribute;Process;Proteins;Reaction;Regulation;response;Role;Signal Transduction;spatiotemporal;Spectrum Analysis;Stimulus;stoichiometry;Structure;Synapses;Synaptic plasticity;three dimensional structure;tool;training opportunity;Variant

PROJECT_TITLE: Molecular computation by the CaMKII holoenzyme


ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: There is a critical need for clinician-scientists possessing the medical training and research experience to conduct basic, clinical and translational research on the mechanisms and treatment of neurological disorders. This Neuroscience Research Education Program at Northwestern (R25) is designed to foster the development of clinician neuroscientists in the Departments of Neurology and Pediatrics (Neurology Division) at Northwestern University's Feinberg School of Medicine via research and educational experiences that will prepare these trainees for independent successful research careers that ultimately will lead to the development of new treatments for neurological disorders.

PI_NAMEs: KESSLER, JOHN A (contact);SIMUNI, TANYA

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Aptitude;Award;Basic Science;career;Clinical;Clinical Investigator Award;Clinical Research;Clinical Sciences;Collaborations;Dedications;design;Development;Education;Education Projects;education research;Educational Curriculum;Evaluation;experience;Faculty;Fellowship;Fostering;Funding;Goals;Individual;Institution;interest;K-Series Research Career Programs;Medical;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;Neurosciences;Neurosciences Research;Pediatrics;Positioning Attribute;Preparation;programs;Qualifying;recruit;Research;Research Personnel;Research Training;Residencies;Resources;Scientist;Secure;success;Supervision;Time;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Education Program for Trainees in Neurology


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROGRAM NARRATIVE  The CTSA Postdoctoral T32 Program at The University of Texas Health Science Center at San Antonio will operate in collaboration with the Institute for Integration of Medicine and Science (IIMS), home for our CTSA. In this innovative 2-year program Trainees will exchange ideas and strategies in a CTS Roundtable with predoctoral, postdoctoral trainees and junior faculty members for successful team science and earn a graduate- level Translational Science Certificate. This next generation of translational scientists will be primed to speed up discovery and implementation for patients and communities.

PI_NAMEs: CHUN, YONG-HEE PATRICIA (contact);FREI, CHRISTOPHER R.

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at The University of Texas Health Science Center at San Antonio


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic kidney disease is a common medical problem that can lead to kidney failure, cardiovascular disease, and premature death. The Chronic Renal Insufficiency Cohort (CRIC) Study is a long-term observational study of more than 5,600 people with chronic kidney disease that aims to identify contributors to adverse outcomes and targets for interventions.

PI_NAMEs: ANDERSON, AMANDA HYRE;DEMBER, LAURA M (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: adjudication;Adult;adverse outcome;Affect;Ancillary Study;Arrhythmia;Biological;Biometry;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;clinical epidemiology;Clinical Trials;cohort;Cohort Studies;Communities;comorbidity;Complex;Data;data acquisition;Data Collection;Data Coordinating Center;data exchange;data integration;Data Sources;design;Development;Disease Progression;Eligibility Determination;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Evaluation;Event;Evolution;experience;follow-up;Funding;Future;Goals;health data;Heterogeneity;Home;Individual;Infrastructure;innovation;Institution;Intervention;Investigation;Kidney Diseases;Kidney Failure;Leadership;Link;Measurement;Measures;Medical;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational epidemiology;Observational Study;Outcome;Output;Participant;participant enrollment;Pathway interactions;Patient Care;Patient-Focused Outcomes;Pennsylvania;Persons;Phase;Phenotype;phenotypic data;Physiological;premature;Process;Productivity;programs;prospective;Prospective cohort;Prospective Studies;Protocols documentation;racial diversity;renal damage;Renal function;repository;Research;Research Personnel;Resources;Risk Factors;Sampling;social;Source;tool;Translational Research;United States;Universities;Visit

PROJECT_TITLE: Continuation of the Chronic Renal Insufficiency Cohort (CRIC)


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Proposed studies will identify the mechanisms by which IRF7 mediates aberrant regulation of antibody-forming cell (AFC) and germinal center (GC) responses, driving the development of autoreactive B cells, autoantibodies and autoimmune disease SLE. We will learn how interplay between B cell metabolism and IRF7 signaling in B cells regulates the magnitude of SLE-associated AFC and GC responses. We will further learn whether IRF7 can be targeted and whether it would be a better option for SLE than T1-IFN blocking therapy.

PI_NAMEs: RAHMAN, ZIAUR  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;American;Antibodies;Antigen-Antibody Complex;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;autoreactive B cell;B cell differentiation;B-Cell Activation;B-Cell Development;B-Lymphocytes;Biochemical Pathway;Bone Marrow;cell type;Cells;Cellular Metabolic Process;Clinical Trials;Data;Deposition;Development;Diphtheria Toxin;Disease;Disease Progression;Disproportionately impacts women;Genes;genome wide association study;Goals;Human;humoral immunity deficiency;Immune system;improved;Inflammation;interferon regulatory factor-7;Interferon Type I;Interferons;Knowledge;Learning;LoxP-flanked allele;Lupus Nephritis;Mediating;Metabolic;Metabolic Pathway;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;Nucleic Acids;Onset of illness;Outcome;pathogenic autoantibodies;Pathway interactions;Patients;Persons;Phase;Plasma Cells;Plasmablast;Production;Publishing;receptor;recurrent infection;Regulation;response;Risk;risk variant;Role;Signal Transduction;Structure of germinal center of lymph node;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T cell response;T-Lymphocyte;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;tissue injury;Toll-like receptors;Toxin Conjugates;transcription factor;type I interferon receptor;Up-Regulation

PROJECT_TITLE: IRF7-mediated development of autoreactive B cells and SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative GABA and Glutathione are key brain chemicals, involved in communication and antioxidant defense respectively. This project will develop new experimental and data processing tools to allow GABA and GSH to be measured at the same time using an MRI scanner.

PI_NAMEs: EDDEN, RICHARD ANTHONY EDWARD (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acceleration;Address;Age;Alzheimer's Disease;Alzheimer's disease patient;Antioxidants;Biochemical;Brain;Chemicals;Clinical;clinical development;Clinical Research;cohort;Communication;Communities;Computer software;computerized data processing;Coupling;Data;data acquisition;Data Analyses;Data Set;Detection;Development;Disease;experimental study;Florida;Foundations;Frequencies;Functional disorder;Funding;gamma-Aminobutyric Acid;Glutathione;Goals;Grant;Human;improved;in vivo;innovation;interest;macromolecule;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Masks;Measurement;Measures;Methodology;Methods;Modeling;neuroimaging;Neurosciences;Neurotransmitters;novel;open source;Oxidation-Reduction;Oxidative Stress;Patients;Phase;Physiologic pulse;Predisposition;Protons;reconstruction;Relaxation;Reproducibility;Resolution;Scanning;Science;sex;Signal Transduction;Site;Slice;Spectrum Analysis;time use;Tissues;tool;Uncertainty;Universities;validation studies;Work

PROJECT_TITLE: Simultaneous Hadamard Editing of GABA and Glutathione

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The Chronic Renal Insufficiency Cohort (CRIC) Study is an NIDDK-sponsored multicenter prospective cohort study investigating novel risk factors for the progression of chronic kidney disease and cardiovascular disease among patients with chronic kidney disease. The CRIC Study may provide insights into the underlying etiology of chronic kidney disease and information for developing interventional studies aimed at reducing the total morbidity and mortality burdens among patients with chronic kidney disease.

PI_NAMEs: CHEN, JING  (contact)

PROJECT_TERMS: Adult;Affect;American;Ancillary Study;Arrhythmia;Behavioral;Biological;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Collection;Data Coordinating Center;data integration;Data Sources;Development;Disease Progression;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Ethnic Origin;Etiology;Event;Evolution;follow-up;Funding;Future;Genetic;Goals;health data;Heterogeneity;Home;home test;Individual;innovation;insight;Institution;Intervention;Intervention Studies;Investigation;Kidney Diseases;Kidney Function Tests;Link;longitudinal, prospective study;Measurement;Measures;Metabolic;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;next generation;novel;Outcome;Output;Parents;Participant;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phase;Phenotype;phenotypic data;Physiological;Population;Premature Mortality;Process;Productivity;programs;Prospective cohort;Prospective, cohort study;Protocols documentation;Publications;quality assurance;Quality Control;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Severity of illness;social;socioeconomics;Source;tool;training opportunity;Translational Research;Visit

PROJECT_TITLE: Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Human noroviruses are a leading cause of acute gastroenteritis. The proposed studies aim to improve our understanding of how these pathogens infect and replicate in intestinal cells, how virus proteins interact with the human host and how they cause disease symptoms. We will also understand how antibody responses protect from norovirus infections and develop drugs that can be used in the treatment of these infections.

PI_NAMEs: ATMAR, ROBERT L.;ESTES, MARY KOLB (contact);PRASAD, BIDADI VENKATARAM

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Address;Anti-viral Agents;Antibodies;Antibody Response;antiviral drug development;Basic Science;Biological Assay;Biology;biophysical techniques;Biosensor;Cell Culture System;Cells;Chemistry;Clinical;Collaborations;combat;Complement;cross reactivity;Cryoelectron Microscopy;Crystallography;Data;design;Development;Disease;Economics;effective therapy;Electron Microscopy;Epitopes;Evaluation;experience;Funding;Gastroenteritis;Gene Modified;Goals;Health;helicase;Human;human stem cell-derived;Immunity;improved;In Vitro;Infection;Infection prevention;inhibitor;insight;Intestines;Knowledge;Mediating;Microscopy;Modeling;Molecular;neutralizing antibody;Norovirus;novel;pathogen;Pathogenesis;Peptide Hydrolases;permissiveness;Persons;Pharmaceutical Preparations;Polymerase;Population;Populations at Risk;Prevention strategy;programs;prospective;protein purification;Proteins;Public Health;receptor;Receptor Cell;Recording of previous events;Regimen;Reproducibility;Research;Research Design;Research Personnel;response;RNA-Directed RNA Polymerase;Role;Services;Site-Directed Mutagenesis;skills;small molecule;Structure;success;Symptoms;Synthesis Chemistry;System;Talents;Testing;Therapeutic;therapeutically effective;treatment strategy;United States;Vaccines;Viral;Viral Antibodies;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virus;virus host interaction;Virus Replication;Virus-like particle

PROJECT_TITLE: Mechanisms of Norovirus Pathogenesis and Replication to Develop Therapeutics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: ESTES, MARY KOLB (contact)

PROJECT_TERMS: Accountability;Accounting;Administrator;Advisory Committees;Animals;Annual Reports;Area;Budgets;college;Communication;Communities;computerized;cost;Ensure;Expenditure;Financial Activity;Funding;Goals;Grant;Human;IACUC;Institutional Review Boards;Laboratories;Lead;Leadership;Logistics;Maintenance;Manuscripts;material transfer agreement;meetings;Microbiology;Molecular Virology;Monitor;National Institute of Allergy and Infectious Disease;Norovirus;Office of Administrative Management;operation;Participant;Pathogenesis;Preparation;programs;Progress Reports;Protocols documentation;Publications;Reagent;Records;Reporting;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resources;Role;Schedule;Services;success;System;Therapeutic;Time;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology

PI_NAMEs: PRASAD, BIDADI VENKATARAM (contact)

PROJECT_TITLE: Microscopy & Enteroids


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: PALZKILL, TIMOTHY  (contact)

PROJECT_TERMS: Affinity;Alanine;Amino Acids;Antibodies;Antibody Affinity;Bile Acids;Binding;Binding Proteins;Biochemical;Capsid;Cells;Chemistry;Complex;Core Facility;Custom;Development;drug discovery;Epitopes;Equipment;experience;Experimental Drug Development;experimental study;Genes;Goals;Human Resources;Immune response;Individual;Infection;inhibitor;interest;Investigation;Label;Ligands;Maps;Measurement;Measures;Metabolic;Methods;Molecular;Mutagenesis;mutant;Norovirus;Pathogenesis;Peptide Hydrolases;Peptide Phage Display Library;Peptides;Performance;Plasmids;Polymerase;programs;Protease Inhibitor;protein expression;protein protein interaction;protein purification;Proteins;receptor;Research Personnel;Resources;Roentgen Rays;Role;Services;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Structure;Structure-Activity Relationship;Testing;Therapeutic;Trefoil Motif;vector;Virus-like particle

PROJECT_TITLE: Protein & Small Molecular Chemistry


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurosciences

ORG_NAME: UNANDUP, LLC

PHR: Arrhythmias are a major cause of US mortality with ventricular fibrillation, ventricular tachycardia, and atrial fibrillation resulting in 430,000 annual deaths. Although catheter ablation is a proven treatment option, as reinforced by the HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement, control of ablation catheters can be complex, resulting in imprecise and unreliable heart-wall contact leading to an increased likelihood of injury and arrhythmia recurrence. UNandUP (short for “Unmet Needs and Underserved Populations”) is developing an affordable angiosuite compatible platform which uses low magnetic fields to overcome prior limitations related to electrophysiology catheter navigational accuracy, stability, and applied forces.

PI_NAMEs: CREIGHTON, FRANCIS MILTON (contact);FADDIS, MITCH

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Ablation;Adopted;Angiography;Animal Model;animal safety;Animals;arm;Arrhythmia;Atrial Fibrillation;biomaterial compatibility;Blood coagulation;Body Weight decreased;Cardiac ablation;Catheters;Cause of Death;Cessation of life;Clinical;Clinical Investigator;Complex;Computer software;Consensus;cost;cost effective;Custom;Cyclic GMP;cytotoxicity;Data Set;design;Development;Devices;digital;efficacy study;Electrodes;Electromagnetics;Electrophysiology (science);Eligibility Determination;experience;Family suidae;Fatigue;Feasibility Studies;fighting;Fluoroscopy;Friends;Funding;Goals;haptics;Heart;heart rhythm;hemocompatibility;Histopathology;Hospitalization;Hospitals;Human;human data;improved;in vivo;Industrialization;Injury;Innovation Corps;invention;Investments;Irrigation;irritation;Laboratories;Learning;magnetic field;Magnetism;Manuals;manufacture;Maps;Mechanics;Medical Care Costs;meetings;Membrane;meter;Methods;Modeling;mortality;National Institute of Neurological Disorders and Stroke;novel;Outcome;Pathway interactions;Performance;phantom model;Pharmacologic Substance;Phase;phase 1 study;Physicians;pre-clinical;Prevalence;prevent;Privatization;Procedures;Property;prototype;Publishing;Recurrence;robotic system;Robotics;Roentgen Rays;Safety;safety assessment;Shapes;Signal Transduction;Software Validation;Surface;System;Technology;Telerobotics;Tensile Strength;Testing;Time;Tissues;Torsion;Toxic effect;Training;Underserved Population;United States National Institutes of Health;Ventricular Fibrillation;Ventricular Tachycardia;Work

PROJECT_TITLE: An Improved Robotic Electrophysiology Platform for Arrhythmia Ablation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

PI_NAMEs: ATMAR, ROBERT L. (contact)

PROJECT_TERMS: Acute;Address;Affinity;Alanine;Anti-viral Agents;Antibodies;Antibody Repertoire;antigen binding;Antigens;antiviral drug development;Bile Acids;Binding;Biological Assay;Blocking Antibodies;Blood Group Antigens;Cell Death;cell type;Cells;Clinical;Clinical Data;clinically relevant;Coculture Techniques;Collaborations;Complement;cross reactivity;cytokine;deep sequencing;design;Development;Disease;drug candidate;Drug Design;drug testing;Enteroendocrine Cell;Epithelial Cells;Epitope Mapping;Epitopes;Evaluation;experimental study;Feces;Gastroenteritis;Gastrointestinal tract structure;Gene Expression Profile;Goals;Grant;Hormones;Human;human data;Immobilization;Immune;Immune response;Immune system;Immunity;improved;In Vitro;in vivo;Individual;Infection;inhibitor;insight;intestinal epithelium;Intestines;Libraries;Maps;Mediating;Mediator;Metabolic;Modeling;Molecular Conformation;Monoclonal Antibodies;Morphology;multiplex assay;Mutagenesis;neutralizing antibody;Norovirus;Norwalk virus;novel strategies;Open Reading Frames;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Peptide Phage Display Library;Peptides;peptidomimetics;Phage Display;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polymerase;preclinical development;Preclinical Testing;prevent;Production;Proteins;Public Health;response;Sampling;Scanning;screening;Serotonin;Serum;Severities;Site;small molecule inhibitor;Symptoms;System;Testing;Therapeutic;Tight Junctions;Time;United States;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Viral;Viral Load result;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases;Virus Inhibitors;Virus Replication;Virus-like particle;Work;X-Ray Crystallography

PROJECT_TITLE: Pathogenesis & Antivirals for Noroviruses


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Nanotechnology;Regenerative Medicine

ORG_DEPT: PHYSIOLOGY

PHR: Narrative: The proposed research is relevant to public health because it may enhance the therapeutic potential of chondrocytes for repairing early stage cartilage injuries and preventing degeneration of the joint, which is an unmet clinical need. The project is relevant to NIH's mission as it will open new horizons for studying how in vitro expansion and chemo-physical cues regulate chromatin organization resulting in the loss or preservation of phenotype, which will be applicable to multiple cell-based therapies.

PI_NAMEs: HEO, SU CHIN  (contact);LAKADAMYALI, MELIKE

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Amino Acids;Animal Model;Architecture;articular cartilage;Biochemical;Biocompatible Materials;Biological Assay;Biology;Biophysics;Cartilage;Cartilage injury;cartilage repair;Cell Differentiation process;Cell Therapy;Cells;Chemicals;Chondrocytes;Chromatin;Clinical;clinical application;clinical practice;Cues;Data;Defect;design;differential expression;Disabling;Disease;Epigenetic Process;Exhibits;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;Heterogeneity;Histologic;Histone Deacetylase Inhibitor;Human;Hydrogels;Hypoxia;Image;Implant;improved;In Vitro;in vivo evaluation;induced pluripotent stem cell;inhibitor;innovation;joint destruction;Knowledge;Label;Machine Learning;machine learning model;Measures;Mechanics;Mesenchymal Stem Cells;Metabolic;Mission;Modeling;Modification;Musculoskeletal;nano;nanoscale;Nanostructures;Natural regeneration;novel;Outcome;Output;Phenotype;Population;preservation;prevent;Production;Property;Proteins;Proxy;Public Health;repaired;Research;Research Personnel;RNA;single molecule;single-cell RNA sequencing;Site;stem;superresolution imaging;superresolution microscopy;Technology;Testing;Therapeutic;Tissue Engineering;tissue regeneration;Tissues;transcriptome;Transforming Growth Factor beta;Translations;Treatment Efficacy;ultra high resolution;United States National Institutes of Health;Work

PROJECT_TITLE: Preserving chromatin nano-structure to enhance chondrocyte therapeutic potential for cartilage repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Achievement;Acute Disease;Animal Model;Anti-viral Agents;Bar Codes;Biology;cDNA Library;Cell Surface Proteins;Cells;Chronic Disease;Clinical Trials;Complement;Complex;cost;Cultured Cells;Data;Dedications;design;Development;Disease;emerging virus;Evaluation;Exhibits;expression vector;fascinate;forward genetics;Functional disorder;Funding;Gene Expression;Genetic;Genetic Screening;Goals;Growth;Growth Factor;Human;Human Cell Line;human stem cell-derived;Immunity;improved;In Vitro;Infection;innovation;insight;Interferons;Intestines;knock-down;Knock-out;Laboratories;Methods;Molecular;Norovirus;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;permissiveness;Persons;pharmacologic;prevent;programs;Proteins;receptor;Regulation;Reporter;Reporting;Reproducibility;Research;Research Personnel;response;RNA replication;Science;sensor;skills;stem cells;System;Talents;Testing;Therapeutic;transcriptome sequencing;Transfection;Tropism;vaccine development;Vaccines;Viral;Viral Physiology;Virus;Virus Receptors;Virus Replication;Virus-like particle

PROJECT_TITLE: Regulation of Norovirus Gene Expression & Replication


NIH_SPENDING_CATS: Diabetes;Microbiome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The gut microbiome are key modulators of human health and disease. To date, we have a limited understanding of the specific gut microbes and microbial derived metabolites contributing to the development of type 2 diabetes. In this Early Stage Investigator NIH R01 application, we propose the largest prospective microbiome study on type 2 diabetes. These studies will reveal the specific gut microbes and microbial derived metabolites and their role in the development of type 2 diabetes in humans.

PI_NAMEs: MAJITHIA, AMIT  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Address;Adipocytes;Bile Acids;Biochemical;Biological;Biological Markers;Branched-Chain Amino Acids;Circulation;Clinical;cohort;Complex;Computational Biology;Data;design;Development;Diabetes Mellitus;diabetic;Disease;dysbiosis;Enrollment;Environmental Risk Factor;Enzymes;Epidemiology;Etiology;Exposure to;Fasting;fasting glucose;fecal microbiome;fecal transplantation;follow-up;Gene Cluster;Genetic;Genome;Glucuronides;gut microbes;gut microbiome;gut microbiota;Health;Hepatocyte;Human;Human Microbiome;In Vitro;in vivo;Individual;Inflammation;Insulin;Insulin Resistance;Interleukin-6;Investigation;Knowledge;Laboratories;Link;machine learning method;Maps;Mass Spectrum Analysis;Mediation;Metabolic;metabolomics;metagenomic sequencing;Metagenomics;Metformin;Microbe;microbial;microbial genome;microbiome;microbiome alteration;microbiome research;Molecular;multidisciplinary;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathology;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasma;prospective;Prospective Studies;Research Personnel;Role;Sampling;secondary metabolite;Shotguns;skills;small molecule;stool sample;United States National Institutes of Health;Validation;Variant;Volatile Fatty Acids;whole genome;Work

PROJECT_TITLE: The role of gut microbes and microbial derived metabolites in the development of type 2 diabetes in humans

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: New therapies are urgently needed to treat patients diagnosed with glioblastoma as current standard of care is rarely curative and often associated with side effects. This research project started by studying the antitumor activity of carbazole-based molecules and led to the development of a series of microtubule targeting agents (ST-compounds) that disrupt microtubule function and kills cancer cells through a unique mechanism that is particularly efficacious in glioblastomas. This new R01 grant will determine how ST-compounds inhibit the fundamental oncogenic behaviors of glioblastomas, including cell division and cell fate, and how this response both compares to known microtubule targeting agents and how it interacts with standard of care DNA- damaging therapies, a body of work that will set a solid foundation to further develop MTAs for the treatment of glioblastomas.

PI_NAMEs: STELLA, NEPHI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Apoptosis;Behavior;Binding;Biological Assay;Biological Models;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;cancer cell;Cancer cell line;cancer type;Carbazoles;Cell Culture Techniques;Cell Cycle;Cell division;cell motility;Cell Survival;Cells;Chromosomal Instability;Colchicine;Collaborations;Coupled;Data;Development;Diagnosis;DNA Damage;Exhibits;experimental study;Faith;Foundations;Genetic;genetic approach;Glioblastoma;Goals;Grant;Growth;Hematologic Neoplasms;Image;in vivo;in vivo Model;innovative technologies;insight;Laboratories;learning algorithm;Link;live cell imaging;live cell microscopy;Malignant - descriptor;Measures;Microscopy;Microtubules;migration;Mitosis;Modeling;Molecular;mouse model;Mus;Non-Malignant;novel;novel therapeutics;Oncogenic;Patients;Penetrance;pharmacologic;Platelet-Derived Growth Factor;pre-clinical;Property;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Reporting;Research Project Grants;response;Series;side effect;Site;Solid;standard care;standard of care;synergism;targeted agent;temozolomide;Testing;Therapeutic;Time;TP53 gene;Treatment Efficacy;treatment response;Tubulin;tumor;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Differential response of glioblastomas to microtubule targeting agents

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology

PROJECT_TERMS: Acute;Anti-viral Agents;Antibodies;antigen binding;antiviral drug development;Architecture;Binding;Binding Sites;Biology;biophysical techniques;Blood Group Antigens;Capsid;Capsid Proteins;Cell-Matrix Junction;Cells;Cellular Membrane;Classification;Complement;Complex;cross reactivity;Cryoelectron Microscopy;Crystallography;Data;design;Development;Drug Design;drug development;drug discovery;Epidemic;Evolution;Gastroenteritis;Genotype;Goals;Grant;helicase;high throughput screening;Human;human monoclonal antibodies;Immunologics;Immunotherapeutic agent;Infection;inhibitor;insight;Interferometry;Intestines;Kinetics;Length;Libraries;Membrane;Membrane Potentials;Methods;Molecular Chaperones;Molecular Conformation;Monoclonal Antibodies;Mutation;nanodisk;neutralizing monoclonal antibodies;Nonstructural Protein;Norovirus;novel;nucleoside triphosphatase;particle;Pathogenesis;Peptide Hydrolases;Pharmaceutical Preparations;Play;Polymerase;Predisposition;Proteins;Protocols documentation;Recombinants;reconstitution;Regulation;Resolution;RNA;RNA Helicase;Roentgen Rays;Role;screening;Screening procedure;small molecule;small molecule inhibitor;Specificity;Structure;syntaxin;System;Techniques;Therapeutic;Trefoil Motif;Vaccines;Virus;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Structural Studies of Noroviruses


ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Project Narrative: We conducted in vivo passaging of Human-Simian Immunodeficiency Virus (HSIV) in pigtailed macaques and recovered infectious molecular clones (IMCs) from the passage 3 macaque. We have observed several non- synonymous mutations throughout the genome of recovered IMCs, perhaps suggesting adaptation to pigtail macaques. In this grant application, we propose to determine the functional significance of mutations observed in envelope gene of recovered IMCs.

PI_NAMEs: THIPPESHAPPA, RAJESH  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Animals;Antibody Response;Applications Grants;beta-Lactamase;Binding;Biological Assay;Blood;CCR5 gene;CD4 Positive T Lymphocytes;Cells;Cloning;cross-species transmission;CXCR4 gene;Dependence;Development;Disease Progression;env Gene Products;experimental study;Genes;Genetic;Genome;HIV;HIV envelope protein;HIV-1;Immune response;Immunocompetent;improved;in vivo;Infection;insight;Interferons;Macaca;Macaca nemestrina;Messenger RNA;Modeling;Modification;Molecular Cloning;Mutation;Names;neutralizing antibody;nonhuman primate;nonsynonymous mutation;novel;Open Reading Frames;Pathogenesis;Pathogenicity;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Plasma;Predisposition;prevent;Protein Family;Resistance;RNA Splicing;RNA-Directed DNA Polymerase;Role;Sampling;Serum;simian human immunodeficiency virus;Site;SIV;Standardization;Testing;vaccine efficacy;vaccine trial;Variant;vif Gene Products;vif Genes;Viral Load result;Viremia;Virion;Virus;Virus Diseases;Virus Replication;vpr Gene Products

PROJECT_TITLE: Determining the Functional Significance of Mutations Observed in Envelope Protein Following Serial In Vivo Passaging of Human-Simian Immunodeficiency Virus

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: The heat shock response (HSR) is a highly conserved adaptive mechanism, regulated by heat shock factors, that acts to help proteins fold and function properly – critical in protecting against neurodegenerative diseases, but also exploited to our detriment to support the anabolic demands of viral infection and cancers. While the mechanistic principles of HSR activation and function have largely been studied in temperature stress, the physiological stresses that are found in normal development and disease are far more complex. This project is focused on elucidating novel mechanisms of heat shock factor function and regulation that are critical for cells coping with growth-related proteotoxic stresses that are relevant to human diseases such as cancer.

PI_NAMEs: MENDILLO, MARC  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acute;Arginine;Binding;Biochemical;biochemical model;biological adaptation to stress;Biological Assay;Biological Models;cancer cell;Cancer Cell Growth;Cell Adhesion;cell growth;Cell Physiology;Cell Proliferation;Cells;Cellular Assay;Chromatin;chromatin remodeling;cofactor;Complex;coping;Cytoprotection;Data;demethylation;Development;Disease;disorder prevention;Disparate;DNA Binding;endoplasmic reticulum stress;Experimental Genetics;Feedback;Gene Expression;Gene Proteins;Genes;Genetic;genetic regulatory protein;Genetic Screening;Genetic Transcription;Genomics;Glucose;Goals;Growth;Health;Health Promotion;Heat shock factor;Heat shock proteins;heat shock transcription factor;Heat Stress;heat-shock factor 1;Heat-Shock Proteins 70;Heat-Shock Proteins 90;Heat-Shock Response;Heat-Shock Transcription Factor 2;Human;human disease;In Vitro;in vivo;Ischemia;Knowledge;Link;Logic;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Metabolic stress;Metabolism;Methods;Modeling;Molecular Chaperones;Mutation;Mutation Analysis;Nerve Degeneration;Neurodegenerative Disorders;novel;Organism;paralogous gene;physiologic stressor;Physiological;Physiology;prevent;Process;programs;Proliferating;promote resilience;protein folding;protein function;protein structure;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;recruit;Regulation;Reperfusion Injury;Reporter;response;Role;Series;Site;Source;Stress;stress resilience;Technology;Temperature;Testing;therapeutic development;Therapeutic Intervention;Transcriptional Regulation;tumor;tumor microenvironment;Viral Cancer;Virus Diseases

PROJECT_TITLE: Regulation and interplay of Heat Shock Factors in growth-associated proteotoxic stresses

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The goal of the GeneNetwork project is to provide a platform of innovation to make the best use of the data and computational tools for systems genetics. We will focus on broadening the impact of the web service by broadening research community participation in the web service and strengthening computational engine powering the web service. We will enhance our database by providing automated tools for data entry and curation (Aim 1); we will improve tools for genetic analysis of high-throughput traits (Aim 2); enable bidirectional information sharing between animal model and human genetic studies (Aim 3); and provide a platform for toolset prototyping and testing by the computational community (Aim 4).

PI_NAMEs: PRINS, PJOTR ;SEN, SAUNAK  (contact);WILLIAMS, ROBERT W.

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: addiction;Animal Model;Area;Bioinformatics;Biological Models;Biology;Caenorhabditis elegans;Candidate Disease Gene;causal model;Code;cohort;Communities;Community Participation;Complex;Computer software;computerized tools;Computing Methodologies;Data;Data Analyses;Data Collection;data curation;data reuse;Data Scientist;Data Set;data sharing;data tools;data visualization;Databases;disorder risk;Drosophila genus;Experimental Genetics;experimental study;FAIR principles;Foundations;Funding;gene network;Generations;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Medicine;genetic resource;Genetic study;genome resource;genome wide association study;genomic data;Genomics;Genotype;Goals;Health;high throughput analysis;high throughput technology;Human;Human Genetics;improved;innovation;insight;Internet;Joints;Knowledge;Linear Models;Link;Machine Learning;Maps;Medical Genetics;Metadata;Methods;model organism;Modeling;Molecular;Motivation;Multiomic Data;Mus;National Institute of General Medical Sciences;Online Systems;Ontology;Organism;pan-genome;Pathway Analysis;Performance;Phenotype;Population;Population Heterogeneity;Positioning Attribute;precision medicine;Programming Languages;prototype;Pythons;Quality Control;Randomized;Rattus;Reproducibility;Research;Research Personnel;Resources;Role;Sample Size;Science;Secure;Ships;simulation;Site;skills;Solid;statistics;Structure;Synteny;System;Testing;Time;Tissues;tool;trait;translational genetics;Translations;Trust;United States National Institutes of Health;Variant;web services

PROJECT_TITLE: A Unified High Performance Web Service for Systems Genetics and Precision Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Over 15 million people worldwide suffer from drug resistant epilepsy (DRE), and the most effective treatment for DRE is to surgically remove the seizure onset zone (SOZ), the region from which seizure activity is triggered. We propose to develop a tool that computes a combined intracranial EEG-fMRI biomarker of the SOZ while a DRE patient is not seizing or at “rest”. The novel biomarker is derived from connectivity properties of dynamical network models constructed from resting state intracranial EEG and fMRI, and may substantially reduce invasive monitoring times, avoiding further risks to patients and reducing costs to hospitals, and improve surgical outcomes.

PI_NAMEs: BOERWINKLE, VARINA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Algorithms;Biological Markers;Brain;Brain region;Child;Clinical;Clinical Data;cohort;Computing Methodologies;cost;Data;Diagnosis;Disease;effective therapy;Electroencephalography;Epilepsy;Evaluation;Functional Imaging;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;generative models;Hospitals;improved;indexing;Intractable Epilepsy;Location;Measures;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;network models;Network-based;novel;novel marker;Operative Surgical Procedures;Outcome;Patients;Pediatric Hospitals;Persons;Pharmaceutical Preparations;Pharmacy facility;precision medicine;Predictive Value;prevent;Property;Research;Rest;Risk;Seizures;signal processing;Societies;Source;Statistical Models;study population;success;surgery outcome;System;Testing;Time;tool;Training

PROJECT_TITLE: CRCNS: Following the BOLD lightening at rest strikes the seizure onset zone!


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hematology;Patient Safety;Prevention;Stroke

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Six million Americans live with atrial fibrillation (AF), a heart rhythm abnormality that is a major risk factor for stroke and only half of those AF patients receive oral anticoagulation. Within the context of an ongoing collaboration between two large learning health systems, we propose to study the impact of a shared clinical decision support tool embedded within the electronic health record designed to enhance guideline-based oral anticoagulation prescription. Using a mixed-methods approach, we will examine how healthcare providers interact with the decision support tool to further refine the tool and measure its impact on anticoagulation prescribing behaviors.

PI_NAMEs: KAPOOR, ALOK  (contact);MCMANUS, DAVID D.

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Adherence;American;Anticoagulants;Anticoagulation;Appointment;Atrial Fibrillation;Behavior;behavioral study;Benefits and Risks;Cardiac;Cardiology;care providers;Caring;Cessation of life;Client satisfaction;clinical decision support;Collaborations;Communication Tools;Data;design;digital;Disparity;Dissemination and Implementation;Educational Materials;Effectiveness;effectiveness measure;Electronic Health Record;Eligibility Determination;Equilibrium;Event;falls;Feedback;Fire - disasters;Florida;Future;Guidelines;health disparity;Health Personnel;Health system;heart rhythm;Hemorrhage;implementation efforts;implementation science;implementation tool;improved;Individual;Informatics;Interview;Ischemic Stroke;Knowledge;Learning;Left;Lifelong disability;Link;Measurement;Measures;medical specialties;Methods;Minority Groups;minority patient;novel;Oral;Outcome;Patient Compliance;Patient Education;Patients;peer support;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;premature;Prevalence;Prevention;Provider;provider intervention;Randomized;Regimen;Reporting;Research;Resources;Risk Factors;safety net;satisfaction;shared decision making;Societies;Specialist;Stroke;Stroke prevention;stroke risk;support tools;Test Result;Testing;tool;Universities;Visit

PROJECT_TITLE: SUPPORT-AF IV