ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This research education program is designed to lead residents in neurology to become outstanding clinician-scientists who will become the next world leaders in discovering how to improve diagnosis, and treatment of neurological disease. It is also aimed to refine the mentoring skills of emerging leaders in the field, so that they can continue this mission in the future.

PI_NAMEs: HILLIS, ARGYE E. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Brain;cellular engineering;Clinical;Clinical and Translational Science Awards;design;Diagnosis;Discipline;education research;education resources;Educational process of instructing;Environment;Evaluation;Faculty;Feedback;Fellowship;Functional Imaging;Funding;Future;Grant;imaging facilities;improved;Investigation;Lead;medical schools;Mentors;Mind;Minority;Mission;Nervous System Disorder;Nervous System Physiology;neurological recovery;Neurology;Neurosciences Research;next generation;Participant;Patient Recruitments;Positioning Attribute;programs;Public Health Schools;Research;Residencies;Resources;role model;Science;Scientist;skills;skills training;Structure;Talents;Time;Training;Woman

PROJECT_TITLE: Research Education Program for Residents and Fellows in Neurology - Angeliki Filippatou


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Direct recording of neural activity from the human brain using implanted electrodes (intracranial EEG, iEEG) is a fast-growing and high-impact technique in human neuroscience. The NIH has mandated data sharing plans for all investigators and funded the creation of open archives for iEEG data, but sharing faces many obstacles. We will remove these obstacles by creating new tools for organizing, sharing and making discoveries from iEEG Data.

PI_NAMEs: MAGNOTTI, JOHN F (contact)

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: 3-Dimensional;Adopted;analysis pipeline;Anatomy;archived data;Archives;Award;Brain;BRAIN initiative;Code;Communities;Complex;Complex Analysis;Computer software;Custom;Data;data exploration;Data Files;Data Set;data sharing;Deep Brain Stimulation;design;Development;Directories;Electrocorticogram;Electrodes;Electroencephalography;experience;Face;Frustration;Funding;Human;Human Activities;Implant;Implanted Electrodes;Ingestion;interest;Internet;Journals;Letters;Libraries;Location;Magnetic Resonance Imaging;Measures;Names;neural;Neuroanatomy;neuroimaging;Neurons;Neurosciences;Output;Patients;Persons;Population;Postoperative Period;Protocols documentation;Pythons;Reproducibility;Research;Research Personnel;Scientist;Software Tools;Specific qualifier value;Structure;System;Techniques;Time;tool;United States National Institutes of Health;Visualization;voltage;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Solutions for Organizing, Sharing and Making Discoveries from iEEG Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (04)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative As artificial intelligence (AI) becomes an ever increasingly component of biomedical research the need for an inclusive trained workforce is essential. The University of Florida (UF) proposes to develop a nation-wide course to upskill biomedical researchers’ expertise in AI while promoting diversity and inclusive excellence for its participants through career development and mentoring. The AI Passport for Biomedical Research (AIPassportBMR) proposal will provide biomedical researchers the opportunity to augment their skills in a concise and comprehensive course based on innovative learning techniques while being mentored by AI experts from across the nation.

PI_NAMEs: BIHORAC, AZRA  (contact);LEVITES STREKALOVA, YULIA A.;SHICKEL, BENJAMIN

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Acceleration;Active Learning;Address;Adopted;Adoption;Adult;Artificial Intelligence;Basic Science;Behavioral Research;Behavioral Sciences;Biomedical Research;Bridge to Artificial Intelligence;career;career development;Clinical Research;Clinical Sciences;Cognitive;Communities;Community of Practice;complex biological systems;Country;Data;Democracy;design;Development;digital;Disease;Disparity;diversity and inclusion;economic implication;Ecosystem;Education;Educational workshop;Effectiveness;Enrollment;Evaluation;Evaluation Methodology;Evolution;experience;Faculty;Feedback;flexibility;Florida;Funding;Future;Generations;Health Sciences;Healthcare;Infrastructure;innovation;Institution;Instruction;Learning;learning community;literacy;Maps;Marketing;Medical;meetings;mentoring community;Mentors;Mentorship;Methodology;mosaic;multidisciplinary;online community;Participant;peer;peer networks;Positioning Attribute;pre-doctoral;Program Development;Program Sustainability;programs;Research;Research Personnel;Research Training;Resources;Self Correction;Shapes;skill acquisition;skills;Societies;socioeconomics;Speed;Technical Expertise;Techniques;Technology;theories;Therapeutic;tool;Trainers Training;Training;Training and Education;Training Programs;United States National Institutes of Health;Universities;Work;Workforce Development

PROJECT_TITLE: Artificial Intelligence Passport for Biomedical Research: Digital Experiential Learning Community for Upskilling in Artificial Intelligence for Biomedical, Behavioral and Clinical Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-V (IP)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Pain Research;Peripheral Neuropathy;Radiation Oncology;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Head and neck cancer standard of care regularly includes radiation therapy which is effective but often results in long-lasting pain. Radiation-induced pain co-develops with oral mucositis, highly symptomatic inflammatory lesions on the oral mucosa. We propose that prophylactic denervation could be an effective strategy to reduce radiation-induced pain and mucositis severity.

PI_NAMEs: MOWERY, YVONNE MARIE;SCHEFF, NICOLE N (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acute;Acute Pain;Affect;afferent nerve;Afferent Neurons;Aftercare;Agonist;Appearance;axonal sprouting;Behavior;Biological Assay;Burning Pain;cancer cell;Cancer Model;cancer pain;cancer therapy;Clinical;Colitis;Data;Denervation;density;Descriptor;Development;Diabetic Neuropathies;Dose;Edema;effective therapy;Enzyme-Linked Immunosorbent Assay;Epithelium;Erythema;Etiology;Growth Associated Protein 43;Head and Neck Cancer;head and neck cancer patient;immunoreactivity;improved;In Vitro;in vitro regeneration;in vivo;Induced Neurons;Inflammation;Inflammatory;irradiation;Keratinocyte cancer;Knowledge;Lesion;Link;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Microfluidics;Modeling;mouse model;Mouth Neoplasms;Mucositis;Mucous Membrane;Mus;Natural regeneration;Nerve;Nerve Fibers;nerve injury;nerve supply;Neurons;Neuropathy;neurotrophic factor;neutrophil;Nociception;Nociceptors;novel therapeutics;opioid therapy;Oral;Oral cavity;oral mucositis;Oral mucous membrane structure;Pain;Pain management;pain model;painful neuropathy;Patients;Peripheral;Persistent pain;Phenotype;pre-clinical;Pre-Clinical Model;pre-clinical research;prophylactic;Psoriasis;Quality of life;Radiation;radiation response;Radiation therapy;Recurrence;regenerative;Reporting;Resiniferatoxin;response;Retrospective Studies;Role;Sensory;Severities;Signal Transduction;standard of care;Standardization;synergism;Testing;timeline;Tissues;Tongue;Transplantation;treatment response;TRPV1 gene;tumor;tumor ablation;tumor microenvironment;Tumor Tissue;Tumor-Derived;Ultraviolet B Radiation

PROJECT_TITLE: Targeting TRPV1-containing nerves for radiation-induced pain and oral mucositis

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Nutrition;Physical Activity;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PHYSIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Using the research approaches in this project, we will determine the role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in cardiorespiratory fitness, including the role of CHIP as a predictor of heterogeneity in responsive to exercise training, which will expand our understanding of the impact of CHIP in cardiometabolic disease. In addition, we will clarify the role of metabolic dysregulation, testing mitochondrial and peroxisomal metabolites in individuals with CHIP and cardiometabolic disease to identify potential mechanistic and future therapeutic targets to improve the lives of people worldwide with cardiovascular disease.

PI_NAMEs: REGAN, JESSICA ANN (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acute;Address;adjudication;age related;aging biomarker;Award;biobank;Biological Markers;biomarker identification;Blood;Cardiometabolic Disease;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chronic;Clinical Trials;Coronary Arteriosclerosis;Coupled;Data;Data Set;Development;Diagnostic;Disease Outcome;Environment;Event;Exercise;exercise intervention;Exercise Therapy;exercise training;Functional disorder;Future;Genes;genetic variant;Goals;Heart failure;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Heterogeneity;high risk;Human;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;Interdisciplinary Study;Intervention;Knowledge;Link;Mediating;Mentorship;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Multiomic Data;Muscle Mitochondria;Mutation;Nonpharmacologic Therapy;novel;novel marker;Obesity;Outcome;Output;Oxygen;Pathway interactions;Patients;personalized care;Persons;pharmacologic;Phenotype;Physicians;Plasma;predicting response;prevent;randomized, clinical trials;Reporting;Research;response;Risk;Risk Reduction;Role;Scientist;Secondary to;sedentary lifestyle;Skeletal Muscle;skills;Systems Biology;targeted sequencing;Testing;Therapeutic;therapeutic target;Time;uptake;Work

PROJECT_TITLE: Age-Related Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Exercise Responsiveness

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M3)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE: In recent years, severe outbreaks and epidemics of Ebola, Lassa, and Zika have illustrated how vulnerable the world is to threats from RNA viral pathogens. To counter the dangers posed by these viruses, we must develop flexible and scalable technologies for diagnostics, surveillance, pathogen discovery and transmission, and deploy them in the most outbreak-prone regions of the world. Here, we will establish the West African Research Network for Infectious Diseases with partners in the United States, Senegal, Sierra Leone, Liberia, and Nigeria, to develop effective strategies, and deploy the necessary tools, for detecting, mitigating, and preventing future outbreaks from emerging and re-emerging infectious diseases.

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact);GARRY, ROBERT F;SABETI, PARDIS CHRISTINE

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acceleration;Acute;Affect;Africa;African;Animals;Area;Awareness;Biological Assay;Chiroptera;Clinical;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communicable Diseases;Communication;Communities;computerized tools;Country;data sharing;Decentralization;Detection;Development;Diagnostic;diagnostic assay;diagnostic criteria;diagnostic technologies;Diagnostic tests;diagnostic tool;Disease Outbreaks;Ebola;Educational workshop;Emerging Communicable Diseases;emerging pathogen;emerging virus;Ensure;Epidemic;Epidemiologist;Evolution;experience;flexibility;Foundations;Frequencies;Funding;Future;future outbreak;future pandemic;genome sequencing;Genomics;Goals;Health;Human;Immune response;improved;Infection;Infectious Diseases Research;Infrastructure;Knowledge;Lassa;Lassa virus;Liberia;metagenomic sequencing;Metagenomics;Methods;microbial;Molecular Epidemiology;National Institute of Allergy and Infectious Disease;Natural History;new outbreak;new technology;Nigeria;novel;Outcome;pandemic potential;pandemic preparedness;pathogen;Pathogenesis;pathogenic virus;Patients;Persons;Prevalence;prevent;Prevention strategy;priority pathogen;Protocols documentation;Public Health;public health emergency;public health intervention;public health relevance;Rapid diagnostics;Reaction;Reagent;Research;Research Personnel;response;Risk;Risk Factors;RNA;RNA Viruses;Rodent;Security;Senegal;Sierra Leone;Standardization;Surveys;System;technology development;Technology Transfer;Testing;tool;Training;transmission process;United States;United States National Institutes of Health;Viral Hemorrhagic Fevers;viral transmission;Virus;Virus Diseases;Work;World Bank;ZIKA

PROJECT_TITLE: West African Emerging Infectious Disease Research Center (WA-EIDRC)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Mental Health;Organ Transplantation;Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE . The proposed research serves public health with its novel focus to improve pediatric liver transplant outcomes by assessing and intervening on children’s underlying health-related social risks, e.g., material economic hardship, social isolation, caregiver mental health, health literacy, and neighborhood characteristics. Integrating a Health Advocate as a member of the post-transplant care team will support the delivery of interventions to overcome barriers interposed by these social risks, with clear potential to close disparities and significantly improve long-term outcomes for these children. The proposed research is directly relevant to NIDDK’s vision to seek insights and answers to bridge health disparities.

PI_NAMEs: WADHWANI, SHARAD  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;adverse outcome;Advocate;California;career development;Caregivers;Caring;Cessation of life;Characteristics;Child;Child Care;Childhood;Clinical;Clinical Trials Design;cohort;Data;Development Plans;Disparity;economic disparity;Economics;efficacious intervention;end stage liver disease;Environment;Ethnography;Family;food insecurity;Foundations;Funding;Future;Goals;graft failure;Health;health disparity;health literacy;Health Services;Health system;Hepatology;high risk;implementation science;improved;improved outcome;insight;Intervention;intervention delivery;Interview;Life;liver transplantation;low health literacy;Measurement;Medical;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methodology;Methods;Multi-Institutional Clinical Trial;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;novel;Nurses;Outcome;Outcome Assessment;Patient Care;Patients;Pediatrics;Physicians;post-transplant;Primary Care;Procedures;professor;prospective;Prospective cohort;Public Health;Research;Research Design;Research Personnel;Research Support;Risk;Risk Factors;Role;San Francisco;skill acquisition;skills;social;social adversity;social health determinants;Social isolation;Social support;Social Workers;socioeconomics;Supervision;Survey Methodology;Testing;Time;Training;transplant centers;Transplantation;Universities;Vision

PROJECT_TITLE: Addressing social adversity to improve outcomes among children undergoing liver transplant: the role for a health advocate on the transplant team

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative This IPERT will help educate the biomedical research workforce of the future in the skills necessary to engage in the broad ecosystem for medical device development across the lifespan. The programming includes case- based coursework, experiential learning, and networking and mentoring opportunities to help participants develop and deepen their skills in reviewing and evaluating medical device proposals. Creation of Individual Development Plans and mentoring teams to support growth for two years following a bootcamp will deepen participants’ expertise, and sustained engagement in medical device development will be tracked during and after the programming to measure impact.

PI_NAMEs: FERRO, DARIA  (contact);GOONERATNE, NALAKA S;WINSTON, FLAURA K

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Academic skills;Acceleration;Accreditation;Active Learning;Address;Adult;Area;Artificial Intelligence;Awareness;Basic Science;bench to bedside;Biological Products;Biomedical Research;Care given by nurses;career;Career Choice;career development;career preparation;case-based;Child;Child Support;Clinical;Clinical Sciences;cohort;Competence;curriculum development;Development Plans;Device or Instrument Development;Devices;Discipline of Nursing;Diverse Workforce;Doctor of Philosophy;Ecosystem;Education;Educational Curriculum;Educational process of instructing;electronic book;Eligibility Determination;empowerment;Engineering;Ensure;Entrepreneurship;ethnic diversity;Evaluation;evidence base;experience;Faculty;Funding;Future;Goals;graduate student;Grant;Growth;Guidelines;Health;Health Care Research;Health Technology;Human Resources;Hybrids;improved;Incubators;Individual;innovation;Innovation Corps;Institution;interest;Knowledge;Learning;learning materials;Life;life span;Link;Marketing;Measures;Medical;Medical Device;Mentors;Mentorship;Methods;Modeling;multimodality;National Institute of General Medical Sciences;novel;open source;outreach;Participant;Pathway interactions;Pediatric Hospitals;Pennsylvania;Persons;Pharmaceutical Preparations;Philadelphia;Physicians;Postdoctoral Fellow;Professional Competence;programs;Public Health;recruit;Regulatory Pathway;Reporting;Research;research and development;research faculty;Research Training;Resources;Safety;Scientist;skills;skills training;social media;Structure;success;symposium;synergism;Technical Expertise;Technology;Time;tool;Training;Training and Infrastructure;Training Programs;Translating;Translational Research;translational scientist;Underrepresented Populations;Universities;user centered design;virtual;Work;Workforce Development

PROJECT_TITLE: Translating Medical Device Discoveries to the Bedside: The Academic Entrepreneurship Awareness to Action (AE2A) Curriculum to Promote Training of a Diverse Workforce


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed study will harness low-field portable MRI technology to accurately measure white matter hyperintensity of the brain. This innovation could democratize brain health assessment, enhance early detection of risk for dementia and stroke, and address existing healthcare disparities by reducing cost and increasing accessibility compared to conventional MRI of the brain.

PI_NAMEs: DE HAVENON, ADAM H. (contact)

PROGRAM_OFFICER_NAME: FARACO, CARLOS CESAR

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;Address;Adult;Age;aggressive therapy;Agreement;alveolar bone;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Assessment tool;automated segmentation;beneficiary;Biological Markers;Blood Vessels;Brain;brain health;brain magnetic resonance imaging;Cardiovascular Diseases;Characteristics;Chronic;Church;Clinic;Clinical;Clinical Trials;cohort;Communities;community center;community setting;Computer software;cost;cost effective;dementia risk;Democracy;Development;Devices;Diabetes Mellitus;diagnostic value;Disadvantaged;disparity reduction;Early Diagnosis;Enrollment;Ensure;Evaluation;FDA approved;Federally Qualified Health Center;Funding;Grant;Health;health assessment;health care disparity;health care settings;Health Personnel;Hospitals;Hypertension;Image;imaging software;improved;inclusion criteria;Individual;innovation;innovative technologies;insight;Intervention;intervention refinement;Licensing;Location;low socioeconomic status;Machine Learning;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Magnetism;Manuals;Measurement;Measures;Medical Imaging;Meta-Analysis;Methodology;Methods;MRI Scans;multidisciplinary;neuroimaging marker;novel;novel strategies;Outcome;Participant;personalized medicine;Physics;Population;portability;Primary Care;Race;Research;Research Personnel;Risk;Risk Factors;risk prediction;rural area;safety net;Severities;Stethoscopes;Stroke;stroke risk;stroke-like outcome;System;Techniques;Technology;Testing;tool;Transcend;ultra high resolution;Validation;vascular risk factor;Vision;Visit;white matter;White Matter Hyperintensity

PROJECT_TITLE: Measuring Brain Health Using Low-Field Portable MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Not only is skeletal muscle a target in sepsis that contributes to worse patient health outcomes, including problems weaning from mechanical ventilation and a greater risk of death, but through release of mtDNA there is strong potential for skeletal muscle to play an amplifying role in driving the systemic inflammation. To address this issue, our project will study a strategy for reducing an event known as mitochondrial permeability transition (mPT) in skeletal muscle on the basis of its potential role in driving muscle dysfunction in sepsis (atrophy, neuromuscular junction impairment) and the fact that mtDNA is released from mitochondria during mPT.

PI_NAMEs: HEPPLE, RUSSELL T (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acetylation;Address;Atrophic;Attenuated;Automobile Driving;Blood;Blood capillaries;Cell Death;Cessation of life;Cholinergic Receptors;Circulation;Complex;Crista ampullaris;cyclophilin D;cytokine;Cytoplasm;density;Event;Experimental Models;Female;Functional disorder;Grant;Health;heart function;high reward;high risk;Impairment;improved;improved outcome;Infection;Inflammation;Inflammatory;Inner mitochondrial membrane;Knock-out;knockout gene;Leukocytes;Link;Liver;male;Mechanical ventilation;Mediating;Membrane Potentials;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Molecular;Morphology;mortality risk;mouse model;Multiple Organ Failure;Mus;Muscle;muscle form;Muscle Mitochondria;Muscle Weakness;Muscular Atrophy;Neuromuscular Junction;old mice;Outcome;Outer Mitochondrial Membrane;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Peptidylprolyl Isomerase;Peritoneal;Permeability;Phosphorylation;Play;Preclinical Testing;Proteins;pulmonary function;Reactive Oxygen Species;Recovery;response;Rewards;Role;Rupture;Sepsis;septic;septic patients;Signal Transduction;Skeletal Muscle;Source;Swelling;systemic inflammatory response;Testing;Therapeutic;Tissues;Toll-like receptors;translational approach;Weaning

PROJECT_TITLE: Targeting mitochondrial permeability transition to attenuate adverse muscle impact in sepsis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Environmental DNA (eDNA) metagenomics is the complex mixture of this genetic material that is found in envi- ronmental samples such as soil, sediment, and water, and thus can be analyzed to create an exact proﬁle of the community of organisms present in that location at certain periods of time, and can provide powerful insights into the invisible diversity of all microbes and other microscopic life that is hidden from the naked eye. eDNA metage- nomics is a powerful tool for monitoring biodiversity and ecosystems that has already provided paradigm shifting revelations into the dynamics of communities and is is quickly transforming many different ﬁelds such as dis- ease monitoring, ecological research, botany, zoology, and even forensics to combat terrorism. In this research proposal, I propose three projects that will leverage eDNA metagenomics to produce results that have better precision and accuracy, and will also leverage the data for new purposes such as distinguishing between differ- ent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, the virus that causes Coronavirus Infectious Disease-19 (COVID19).

PI_NAMEs: PIPES, LENORE  (contact)

PROJECT_TERMS: 2019-nCoV;Algorithms;Area;Bayesian Method;Biodiversity;Bioinformatics;Botany;Classification;combat;Communities;Complex Mixtures;computer science;Computer software;Computing Methodologies;COVID-19;COVID-19 monitoring;Custom;Data;Data Set;Data Storage and Retrieval;Databases;Disease;Disease Outbreaks;DNA;Early Diagnosis;Ecosystem;Environmental Monitoring;expectation;Eye;Forensic Medicine;Genetic Materials;Genome;Genomics;Goals;Human Microbiome;in silico;insight;Life;Location;Metagenomics;Methods;Microbe;microbiome analysis;Microscopic;Monitor;next generation sequencing;Nucleotides;open source;Organism;pandemic disease;Pathogen detection;Phylogenetic Analysis;Phylogeny;Population Sizes;Public Health;Research;Research Personnel;Research Proposals;Sampling;Soil;statistics;Systems Biology;Taxonomy;Terrorism;Time;tool;Trees;Viral;viral detection;Virus;wastewater monitoring;wastewater samples;wastewater surveillance;Water;web portal;Zoology

PROJECT_TITLE: Phylogenetic and computational methods for accurate and efficient analyses of large-scale metagenomics datasets


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PHR: Narrative Xylazine-adulterated fentanyl has emerged as a public health threat, particularly in the Northeastern and Mid- Atlantic states, and is contributing to severe injection-related infections and other harms. Amidst this drug supply transition, researchers have begun to document transitions to low-frequency injecting or injection cessation among people otherwise continuing to use fentanyl. This two-year qualitative study seeks to characterize the dynamics shaping these drug use transitions and their implications for public health and overdose prevention through qualitative interviews with a diverse sample of people who use drugs in Connecticut who have transitioned to low-frequency injecting or injection cessation, as well as complementary focus groups with harm reduction workers.

PI_NAMEs: MCNEIL, RYAN  (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Address;Automobile Driving;Awareness;Clinical;Communicable Diseases;Communities;Community Health;Connecticut;Country;COVID-19 pandemic;design;Development;disease transmission;drug market;Drug usage;drug use behavior;Drug user;Effectiveness;Ensure;Environment;Epidemic;Equity;experience;Exposure to;Fentanyl;fentanyl use;Focus Groups;Frequencies;gender diversity;Harm Reduction;Health;health organization;Hepatitis C;Heroin;HIV;Homelessness;Hospitalization;Illicit Drugs;Individual;Infection;Inhalation;injection drug use;Injections;interest;Intervention;Interview;manufacture;Maryland;Naloxone;Needle-Exchange Programs;New England;Overdose;overdose death;overdose prevention;Pennsylvania;Perception;Persons;Pharmaceutical Preparations;Policies;Population;Poverty;prescription opioid;programs;Proliferating;Public Health;racial diversity;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Sampling;Sedation procedure;service delivery;Services;Shapes;Smoking;social;social structure;Soft Tissue Infections;Tranquilizing Agents;Volatilization;Xylazine

PROJECT_TITLE: Xylazine exposure and transitions to low-frequency injecting and injection cessation

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Spatial context can have implications for the cognitive health and well-being of Black men because place can influence interactions between social environment, cumulative stress, and biological responses. No studies to our knowledge have examined the association between place, stress, and cognitive status among this population and we propose to address this gap with a small study analyzing data from the Health and Retirement Study and U. S. Census. Results from the proposed secondary data analysis can provide evidence for a full-scale observational study and inform risk reduction interventions to preserve cognitive function, prevent cognitive impairment, and extend longevity among middle age and older Black men.

PI_NAMEs: BRUCE, MARINO A (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Aging;allostatic load;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Attention;Behavioral;behavioral response;Biological;Biological Factors;biopsychosocial;Black American;black men;Censuses;Cognitive;cognitive function;Collaborations;Complex;Data;Data Analyses;Discrimination;Economics;Elements;Environment;Environmental Risk Factor;epidemiologic data;Equation;evidence base;experience;Exposure to;Future;Generations;Genetic;Genetic Predisposition to Disease;Geographic Factor;Geography;Health;Health and Retirement Study;health data;health disparity;heuristics;high risk;human old age (65+);Impaired cognition;Impairment;Individual;Institution;Intervention;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;Logistic Models;Longevity;longitudinal, prospective study;male health;marginalized population;Measures;men;middle age;Minority;Modeling;National Institute on Aging;Neighborhoods;observational cohort study;Observational Study;Pathway interactions;Personal Satisfaction;Physiological;Play;Population;Premature Mortality;preservation;Prevalence;prevent;programs;protective factors;psychologic;Psychological Factors;Psychological Impact;racial population;Research;Research Personnel;research study;residential segregation;Resources;response;Risk;Risk Factors;Risk Reduction;Sampling;social;social culture;Social Environment;social factors;social stressor;Societal Factors;Sociology;Specific qualifier value;Stress;stressor;Structural Racism;theories;therapy design;United States;Women's Group;Work

PROJECT_TITLE: Place, Stress and Cognitive Status Among Black Men during middle and late life

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Infant Mortality;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: LEXINGTON

ORG_NAME: BIOPTICSTECHNOLOGY, LLC

ORG_STATE: KY

PHR: PROJECT NARRATIVE Continuous monitoring of neonatal brain development is crucial for effective management of brain injury and associated complications, thus reducing healthcare burden and costs. Bioptics Technology is developing, validating, and commercializing a revolutionary time-resolved laser speckle contrast imaging (TR-LSCI) technology that enables noncontact, fast, high-resolution imaging of cerebral blood flow and resting-state functional connectivity across distinct regions of the brain for noninvasive and continuous assessment of neonatal brain development to prevent brain injury. While the proposal tests this imaging technology in perinatal hypoxic-ischemic encephalopathy models of neonatal rats and piglets as the first step for preclinical commercialization, the TR-LSCI device is broadly applicable to investigate many neurovascular diseases beyond HIE occurring in human neonates, thereby providing a significant opportunity for future clinical development and commercialization.

PI_NAMEs: YU, GUOQIANG  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: 3-Dimensional;Affect;Algorithms;Animal Model;Biological Markers;biomarker identification;Brain;brain abnormalities;Brain imaging;Brain Injuries;Brain region;Calibration;care costs;cerebral hemodynamics;Cerebrovascular Circulation;Clinical;clinical application;clinical development;Collaborations;commercialization;Complex;Consumption;cost;cranium;denoising;design;Development;Diffuse;diffuse optical tomography;Diffusion;Disease;Early Diagnosis;Electroencephalography;experimental study;feasibility testing;Functional Magnetic Resonance Imaging;Future;Head;Health;healthcare burden;high resolution imaging;Human;Image;imager;Imaging Device;Imaging technology;improved;in vivo;Infant;Investigation;Kentucky;Laboratories;Laser Speckle Imaging;lens;Light;Magnetic Resonance Imaging;Maps;Methods;Modality;Modeling;Monitor;mortality;Near-Infrared Spectroscopy;Neonatal;neonatal brain;neonatal brain development;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonate;Neurodevelopmental Problem;neuroimaging;Neurosciences Research;neurovascular;Noise;Operating System;operation;Outcome;Pathology;Perinatal anoxic ischemic brain injury;Phase;Photons;Physiologic pulse;porcine model;portability;Positron-Emission Tomography;pre-clinical;prevent;Property;prototype;Rattus;reconstruction;Resolution;Rest;Risk;Rodent;Scalp structure;Signal Transduction;Small Business Technology Transfer Research;Statistical Models;System;Technology;Term Birth;Testing;Time;Tissues;tomography;Universities;user-friendly;Variant

PROJECT_TITLE: Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE  Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on transfluthrin-treated hessian fabric strips through meta-analysis of Tanzanian studies, semi-field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs.

PI_NAMEs: CHEN, INGRID TING-TING (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Achievement;Affect;Africa;Area;Beds;Bite;Cambodia;Cambodian;Characteristics;Climate;Culicidae;Data;design;Detergents;Disorientation;Entomology;evidence base;Evolution;experience;field study;forest;Formulation;Foundations;Frequencies;Future;Health behavior change;high risk population;High temperature of physical object;Human;Humidity;Insecticides;Interruption;Intervention;Intervention Studies;Latin America;Malaria;malaria transmission;Mentorship;Meta-Analysis;Pharmaceutical Preparations;preference;protective efficacy;public health intervention;Publishing;Rain;Research;Research Design;Research Personnel;Residual state;scale up;Shapes;skills;small molecule;Source;Southeastern Asia;Surface;Tanzania;Temperature;Testing;Textiles;Thailand;Theory of Change;therapy design;therapy development;Time;Training;transmission process;uptake;vector;Volatilization;Water;Weather

PROJECT_TITLE: Spatial repellents to reduce the outdoor transmission of malaria

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Disrupted signal processing in the principal neurons of basal ganglia is believed to be a key factor in the cause of a number of neurological symptoms including involuntary movements, debilitating tremors, and rigidity. We will study electrical events in two dominant classes of basal ganglia neurons in order to understand how signals that come into neurons are processed, and how best to fix-up the signal processing to correct defects caused by illness.

PI_NAMEs: ANTIC, SRDJAN D (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Affect;Animal Disease Models;Animal Model;antagonist;Apamin;Axon;Back;Basal Ganglia;Basal Ganglia Diseases;cell type;Cells;channel blockers;Complex;Comprehension;Computer Models;Computer software;Corpus striatum structure;Data;Deceleration;Defect;Dendrites;Disease;disease model;Disparity;Distal;Dopaminergic Cell;dopaminergic neuron;Drug usage;Electrodes;Equilibrium;Event;Excitatory Postsynaptic Potentials;experimental study;Fiber;Frequencies;Generations;Huntington Disease;Image;Imaging Techniques;Individual;information processing;Investigational Therapies;Involuntary Movements;Levodopa;Measurement;Measures;Modeling;motor symptom;N-Methylaspartate;Nerve Degeneration;Neural Pathways;Neurologic Symptoms;neuronal cell body;Neurons;non-motor symptom;Output;Parkinson Disease;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Play;Potassium Channel;Process;Property;Protective Agents;protective effect;Publishing;regeneration potential;Research;Research Personnel;Role;RTN4 gene;signal processing;Signal Transduction;Site;stem;Synapses;Synaptic Potentials;System;Testing;theories;translational study;Travel;Tremor;voltage;Weight

PROJECT_TITLE: Electrical Signaling in Dendritic Branches

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is one of the leading causes of mortality in the U.S. and lowering the burden of CVD through prevention and treatment is important to public health. Immigrants of color have lower awareness, screening, monitoring, and treatment of CVD risk factors than U.S.-born populations, which may contribute to the observed decline in their cardiovascular health over longer residence in the U.S. This project will use epidemiologic, system dynamics, and community-engaged methods to understand and quantify how different facets of the sociopolitical environment affect Black and Latinx immigrants’ CVD preventive care utilization.

PI_NAMEs: CROOKES, DANIELLE MARIE (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult;Affect;Awareness;Behavior;Black race;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;Color;Communities;community based participatory approach;community engaged research;Community Health Networks;Complex;County;Data;Data Analyses;Diagnosis;disparity elimination;dynamic system;Electronic Health Record;Environment;Epidemiologist;Epidemiology;Ethnic Population;experience;Exposure to;Feedback;Goals;hate crimes;Health;health care availability;health care service utilization;health difference;Immigrant;Immigration;improved;Individual;Interdisciplinary Study;Interpersonal Relations;Intervention;K-Series Research Career Programs;Knowledge;Latinx;longitudinal analysis;Maps;Measurement;Measures;Mental Health;Methods;model building;Modeling;models and simulation;Monitor;mortality;National Heart, Lung, and Blood Institute;Neighborhood Health Center;novel;Outcome;Policies;Politics;Population;Prevention;Preventive care;Public Health;racial population;racism;Research;Research Personnel;residence;Risk Factors;screening;simulation;skills;social;Structure;study population;System;Time;Training;Training Activity;trend;Victimization

PROJECT_TITLE: Understanding immigrants' cardiovascular disease utilization: An epidemiological and system dynamics approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Polycystic Kidney Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE The limited success in translating studies from mouse models of cystic disease to patients is likely multifactorial and includes the variety of animal models that are used for preclinical studies and the limited bioavailability of candidate drugs in patients. For example, researchers often use cystic models that have different underlying genetic mutations and progress at variable rates interchangeably; however, it is currently unknown how the molecular and cellular pathophysiology of PKD patients translates to mouse models. In this application, we propose to address this gap in knowledge by generating a cross model and species single cell atlas of cystic kidney disease, which can be used to predict mouse models that most closely recapitulate human disease as well as identify evolutionarily conserved, known and novel intra- and inter-cellular signaling networks involved in PKD.

PI_NAMEs: MA, ANJUN ;ZIMMERMAN, KURT A (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Atlases;Autosomal Dominant Polycystic Kidney;Biological Availability;Cells;Cilia;Communities;congenic;Cyst;Cystic Kidney Diseases;Data;deep learning;deep learning model;Development;Disease;disease phenotype;DNA Sequence Alteration;drug candidate;Epithelial Cells;Epithelium;Family;Functional disorder;Generations;Genes;Goals;Graph;Human;human disease;immune function;interest;Kidney;Kidney Failure;Knowledge;Learning;Liquid substance;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Mutation;new therapeutic target;novel;novel therapeutics;Orthologous Gene;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;PKD1 gene;PKD2 gene;Polycystic Kidney Diseases;preclinical study;Proteins;Reporting;Research;Research Personnel;Resources;Severity of illness;Signal Transduction;single-cell RNA sequencing;Stromal Cells;success;Technology;Therapeutic;therapeutic target;tool;Training;Translating;Update;user-friendly;Variant;web portal

PROJECT_TITLE: Constructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Residents of Puerto Rico (PR) experience a great burden of cardiometabolic diseases and have been disproportionately exposed to unique social and environmental stressors. The research and training goals of this K01 center around investigating negative affect and dysfunctional eating behaviors as pathways by which chronic and daily stressors may affect the cardiometabolic function of adults in PR. Findings will inform theory, intervention targets, and the understanding of the impact of stress on cardiometabolic health of high-risk and underserved populations.

PI_NAMEs: LOPEZ-CEPERO, ANDREA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acute;acute stress;Adult;Adverse event;Affect;Area;Behavioral;Belief;biological adaptation to stress;Biological Factors;Blood Glucose;blood lipid;Blood Pressure;Blood Pressure Monitors;Blood specimen;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;catalyst;Chronic;Chronic Disease;Chronic stress;Complex;Continuous Glucose Monitor;coping;COVID-19 pandemic;culturally appropriate intervention;Data;Disease Marker;disorder risk;Eating;Eating Behavior;Ecological momentary assessment;Emotional;Environment;environmental stressor;Epidemiology;epidemiology study;experience;Exposure to;Financial Hardship;follow-up;Food;Funding;Geographic Locations;Glucose;Goals;Grant;Health;health equity;high risk;Hurricane;Hyperlipidemia;Hyperphagia;Hypertension;implementation evaluation;Intervention;Intrinsic factor;Island;Knowledge;Latinx;Latinx population;Leadership;Link;Measurement;Measures;Mediating;Mentored Research Scientist Development Award;Mentors;Modeling;monitoring device;National Heart, Lung, and Blood Institute;Natural Disasters;Nature;negative affect;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Observational Study;Overweight;Participant;Pathway interactions;Persons;Physiological;Pilot Projects;Politics;Population;post-doctoral training;Poverty;Psychosocial Assessment and Care;Psychosocial Factor;Puerto Rico;Questionnaires;Recovery;Reporting;Research;Research Personnel;resilience factor;response;Role;social;social stressor;Social support;Spirituality;Standardization;Stress;stress management;stressor;Testing;theories;Time;Training;Translating;trend;Underserved Population;United States National Institutes of Health;wearable device;Work;Writing

PROJECT_TITLE: Chronic and daily stressors, dysfunctional eating behaviors and cardiometabolic risk among adults in Puerto Rico


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: BOISE

ORG_NAME: CARING TECHNOLOGIES, INC.

ORG_STATE: ID

PHR: PROJECT NARRATIVE There is an increasing trend (a) for children with autism spectrum disorder (ASD) with primary behavioral challenges to be hospitalized in medical facilities because accessible behavioral support resources are not available in local communities and (b) for these hospitalizations to be extremely challenging for children, families, providers, and systems of care (i.e. prolonged hospitalizations; challenges with discharge to step- down facilities; use of restraint, sedation, etc.; high-levels of staffing; un/unreimbursed care for hospitals). Appropriate telehealth and digital health systems that can facilitate tele-mediated behavioral support during hospitalization and through discharge transition may hold great potential for increasing the availability of such care to children, families, and the providers and hospitals responsible for their care. The current project creates and tests the potential clinical value of an innovative telehealth platform to facilitate appropriate, efficacious ABA tele-assessment and intervention for adolescents with ASD displaying challenging behaviors during hospitalizations and post-discharge transition which could powerfully enhance care systems for individuals with ASD and severe challenging behavior that may require intensive support at times in low resource settings.

PI_NAMEs: OBERLEITNER, RONALD  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: adolescent with autism spectrum disorder;Adoption;applied behavior analysis;autistic children;Behavior;Behavioral;care providers;care systems;Caregivers;Caring;Child;Clinical;clinical decision support;commercialization;Communication;Communities;Cost Analysis;Custom;Data;design;digital health;Evaluation;experience;Family;feasibility testing;Feedback;Geographic Locations;Guidelines;Health Insurance Portability and Accountability Act;Health system;Home;hospital care;hospital readmission;Hospitalization;Hospitals;Human;Hybrids;improved;individuals with autism spectrum disorder;innovation;Instruction;Insurance Claim Review;Intervention;Length;Measures;Mediating;Medical;Medical Staff;Medicine;novel;Outcome;Parents;Patients;Pattern;Persons;Phase;Positioning Attribute;Process;prototype;Provider;recruit;Report (document);Research;Resource-limited setting;Resources;restraint;Sampling;satisfaction;Schools;Security;Sedation procedure;Services;skills;Structure;success;support tools;System;Technology;tele-evaluation;telehealth;telehealth systems;Testing;Time;trend;usability;Videoconferencing;Work

PROJECT_TITLE: Transforming Hospitalizations of Autistic Adolescents via a Novel ABA Telehealth Platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Biotechnology;Brain Disorders;Cancer;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: An ongoing problem in drug development is that many therapeutics have side effects on the brain; for example, certain anti-cancer agents cause impairments in thinking (“chemofog”) which often persist following cessation of the cancer therapy, and medications used to treat AIDs may also impair thinking. Pharmaceutical companies currently test potential therapeutics for toxicity to the nervous system on animals (e.g., mice, and dogs), but harmful effects to the human nervous system are often first revealed in human clinical trials. Our project will develop a novel system to test candidate therapeutics for toxic effects on neurons derived from human adult stem cells (human embyos are not harmed in the preparation of the stem cells) which will be more predictive than animals, improve the efficiency and effectiveness of drug development, and reduce the use of animals in preclinical research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: abuse liability;Action Potentials;Affect;Aftercare;Algorithms;Alzheimer's Disease;Animal Testing;Animals;anti-cancer;Antineoplastic Agents;antiretroviral therapy;Apolipoprotein E;apolipoprotein E-3;Arrhythmia;Artificial Intelligence;Astrocytes;Biological Assay;Bipolar Disorder;Black Box;Brain;BRAIN initiative;Calcium;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;Canis familiaris;Carcinogens;Cardiac Myocytes;Cardiovascular system;Cell membrane;Cell Survival;Cells;Chemotherapy-induced peripheral neuropathy;Classification;Clinical;clinical effect;clinical predictors;Clinical Trials;Coculture Techniques;Complex;compound 30;cost;Cytosol;Data;Development;Disease;DLG4 gene;dosage;Dose;Dose Limiting;drug development;drug discovery;Drug Prescriptions;Drug toxicity;Effectiveness;Endoplasmic Reticulum;endoplasmic reticulum stress;experience;Failure;FDA approved;Feeling suicidal;Genotype;Goals;Headache;Hepatic;high throughput screening;HIV;HIV anti-retroviral;HIV-associated neurocognitive disorder;Hour;Human;human adult stem cell;human induced pluripotent stem cells;Image;Image Cytometry;Impaired cognition;Impairment;improved;In Vitro;in vivo;Incubated;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Institution;Ion Channel;Kinetics;Label;Lead;lead series;Malignant Neoplasms;manufacturing scale-up;Marketing;Measures;Membrane;Microglia;Mitochondria;Modeling;multiplex assay;Mus;Mutation;Nervous System;neural circuit;Neurodegenerative Disorders;Neuroglia;Neurologic;neuronal circuitry;Neurons;neurotoxic;neurotoxicity;novel;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Poison;postsynaptic;pre-clinical;pre-clinical research;preclinical development;Preclinical Testing;predicting response;Preparation;presynaptic;programs;Publishing;Quality Control;Reporting;response;retinal toxicity;Robotics;Safety;safety study;Sales;Science;screening;screening services;Sedation procedure;Seizures;Sensitivity and Specificity;side effect;Small Business Innovation Research Grant;stem cells;Synapses;Synapsins;System;Testing;Therapeutic;therapeutic candidate;Thinking;Tissue Model;Toxic effect;toxicant;Toxin;Training;Treatment-related toxicity;United States National Institutes of Health;Validation;Variant;Virus Diseases;voltage

PROJECT_TITLE: Neural Circuits, Kinetics and Energetics HTS of Human iPSC-Neurons, -Microglia, and -Astrocytes: AI-Enabled Platform for Target ID, and Drug Discovery and Toxicity (e.g., Cancer Chemo & HIV ARTs)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Infectious Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal is relevant to public health as it addresses a serious infectious disease in one of our most vulnerable populations, preterm infants. Our research team will evaluate strategies to reduce human milk transmission of cytomegalovirus (CMV) infection in preterm infants. The application of knowledge gained will reduce CMV illness and long-term disability.

PI_NAMEs: MARTIN, CAMILIA R (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Admission activity;Antibodies;Area;Avidity;Biological Markers;Birth;Breast Feeding;Bronchopulmonary Dysplasia;Cellular Infiltration;Clinical;Clinical Trials;Communicable Diseases;Cytomegalovirus;Cytomegalovirus Infections;Data;Development;Disease Outcome;disorder risk;Drug Kinetics;Effectiveness;experimental study;Exposure to;Failure;Fatty Acids;feeding;Female of child bearing age;Funding;Future;Gastrointestinal tract structure;Grant;Growth;Health;hearing impairment;Human Milk;Immune response;Immunoglobulin G;Impairment;Infant;Infant Health;Infection;infection rate;Inflammatory;inflammatory milieu;Inflammatory Response;Interruption;Intervention;Intervention Trial;intestinal epithelium;Knowledge;Lactation;lipid metabolism;lipidome;lipidomics;Long term disability;Lung Diseases;mammary;Measures;metabolome;metropolitan;microbiome;Milk;Monoclonal Antibodies;Morbidity - disease rate;Mothers;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;neonatal outcome;Neonatology;Neurodevelopmental Impairment;neutralizing antibody;novel strategies;nutrition;Nutritional;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;point of care;Population;postnatal;Premature Birth;Premature Infant;Production;Proteins;Public Health;Research;respiratory;response;Risk;risk mitigation;Risk Reduction;Role;Safety;Secure;Sepsis;seropositive;Syndrome;Systemic infection;Testing;Toxic effect;translational potential;transmission process;Tube;vaccine development;Virus;Virus Diseases;Virus Replication;Virus Shedding;Vulnerable Populations;Woman

PROJECT_TITLE: CMV+ milk: morbidity risk & translational potential of neutralizing antibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: The US spends more than $635 billion per year on chronic pain, however, the currently available drugs are not effective and often lead to dependence. Neurobiological, genetic, and preclinical studies have suggested that inhibitors of adenylyl cyclase type I (AC1) offer an alternative target. We have discovered a novel scaffold of AC1 inhibitors and propose a molecular pharmacological characterization of these small molecule inhibitors as a logical extension of the parent award.

PI_NAMEs: FLAHERTY, DANIEL PATRICK (contact);WATTS, VAL J

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute;Adenylate Cyclase;adenylyl cyclase 1;Analgesics;analog;Animal Model;Chronic;chronic pain;chronic pain management;Collection;cost;Cyclic AMP;Dependence;Development;Drug Targeting;efficacy evaluation;Forskolin;Genetic;Genetic study;Goals;GTP-Binding Protein alpha Subunits, Gs;in vitro Model;in vivo;Inflammatory;inflammatory pain;inhibitor;insight;Knockout Mice;Lead;lead optimization;Molecular;mouse model;Mus;Neurobiology;Neuropathy;New Agents;new therapeutic target;novel;Opioid Receptor;painful neuropathy;parent project;Parents;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;preclinical study;prevent;Property;Pyrimidinones;Rattus;Regulation;response;scaffold;Signal Transduction;Site-Directed Mutagenesis;small molecule inhibitor;small molecule libraries;Structure-Activity Relationship;Time;Validation

PROJECT_TITLE: Pharmacological validation of adenylyl cyclase 1 as a drug target for chronic pain

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE There is an increasing call for real-world relevance in neurorehabilitation including the rehabilitation of people following severe traumatic brain injury (sTBI). Enriched environments have the potential to provide a sustainably motivating, social and multimodal therapy platform. This project will quantify the efficacy of training people with chronic sTBI in the enriched environment of a therapeutic café as compared to conventional therapy.

PI_NAMEs: GALLOWAY, JAMES C.;SULZER, JAMES  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Adult;Animal Model;Area;Behavioral;Case Study;Chronic;Clinical;clinical implementation;Clinical Research;Clinical Trials;Cognition;Cognitive;Cognitive deficits;Combined Modality Therapy;Communities;Community Participation;comparative efficacy;conventional therapy;cost;Data;data sharing;Dose;Elements;Engineering;Environment;environmental enrichment for laboratory animals;Equilibrium;Exclusion;experience;experimental study;falls;Follow-Up Studies;Food Packaging;Gait;Goals;hand rehabilitation;Home;Hour;Human;improved;Individual;Injury;innovation;International;Joints;kinematics;Life;Limb structure;Lower Extremity;Measures;Modeling;Motion;motor deficit;multimodality;neurological rehabilitation;Neuronal Plasticity;Neurosciences Research;Occupational Therapy;Outcome;Outpatients;Participant;patient engagement;payment;Persons;Phase;Physical activity;Physical Function;Physical therapy;Pilot Projects;Population;Process;programs;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Research;Research Personnel;response;Schools;skills;social;Social isolation;Societies;Speech;Sterility;Stimulus;Supervision;Survivors;System;technology/technique;Testing;Therapeutic;Therapeutic Intervention;Training;Training Programs;Training Technics;Translating;Traumatic Brain Injury;Upper limb movement;user-friendly;Vocation;Vocational Education;Walking;wearable sensor technology;Work

PROJECT_TITLE: An Enriched, Immersive Rehabilitative Environment for Those with Traumatic Brain Injury

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Project Narrative Age-related neurodegenerative diseases like glaucoma have no cure and are a significant public health burden. Fibrosis at the optic nerve head drives significant pathology in glaucoma, and our research identifies a new pathway in which to intervene to correct the fibrotic dysregulation. Findings from this study will inform the development of novel therapeutics to prevent or slow the progression of glaucoma.

PI_NAMEs: INMAN, DENISE M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: age related neurodegeneration;Amino Acids;Astrocytes;Axon;Axonal Transport;Catabolism;Cell Separation;Cells;Collagen;Cytoskeleton;design;Development;Dose;enzyme pathway;Enzymes;Extracellular Matrix;Feedback;Fibrosis;Genetic Transcription;Glaucoma;Glutamine;Goals;Human;Hypertrophy;Inflammation;inhibitor;Injury;Integrins;Learning;Link;mechanotransduction;Metabolic;Metabolic Pathway;Metabolism;Mus;novel therapeutics;Optic Disk;Pathologic;Pathology;Pathway interactions;Patients;Physiologic Intraocular Pressure;prevent;Primary Open Angle Glaucoma;Production;promoter;Public Health;Research;response;Retinal Ganglion Cells;Signal Pathway;Signal Transduction;stable isotope;Stress;Stretching;Structure;Testing;Transcription Coactivator;Work

PROJECT_TITLE: Optic nerve head metabolic change promotes fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

PHR: Narrative Population imaging of neural activity in vivo is an important approach to investigate neural coding and circuit function, and to discover how circuit function is compromised in disease. This project focuses on 2-photon imaging of genetically encoded voltage indicators (GEVIs) in cerebral cortex, which records neural activity a fast, physiologically relevant time scales. This project optimizes 2-photon GEVI imaging methods and applies them to study the processing of sensory and cognitive information in mouse sensory cortex.

PI_NAMEs: FELDMAN, DANIEL  (contact);JI, NA

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: awake;Beds;Biological Markers;Calcium;Calibration;cell type;Cells;Cerebral cortex;Code;Cognitive;Collaborations;Detection;detection method;deviant;Disease;Electroencephalography;expectation;extracellular;Generations;Health;hippocampal pyramidal neuron;Image;imaging modality;improved;in vivo;in vivo imaging;Interneurons;Learning;Measurement;Measures;method development;Methods;millisecond;Modeling;Modernization;Mus;neural;neural network;neuroimaging;Neurons;Neurophysiology - biologic function;Noise;novel;Optics;Parvalbumins;Pattern;Physiological;Population;predictive modeling;Pyramidal Cells;Records;recruit;Recurrence;Reporting;Resolution;response;Schizophrenia;segregation;Sensory;sensory cortex;sensory stimulus;Signal Transduction;somatosensory;Somatosensory Cortex;Somatostatin;Stimulus;temporal measurement;Testing;Time;Touch sensation;Toxic effect;two-photon;Vasoactive Intestinal Peptide;Vibrissae;voltage;Work

PROJECT_TITLE: Population voltage imaging of sensory and cognitive signals in somatosensory (S1) cortex

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Recurrent medulloblastoma and high grade glioma are universally fatal, however, targeting human cytomegalovirus antigen pp65 using a peptide vaccine (PEP-CMV) has produced promising preliminary results. This project focuses on elucidating the expression of CMV antigens in ependymoma and combining PEP-CMV with checkpoint blockade to increase immunogenicity. Expanding the eligibility of who may benefit from PEP-CMV and enhancing immune responses has the potential to improve the survival and quality of life of children with high grade glioma, medulloblastoma, and ependymoma.

PI_NAMEs: THOMPSON, ERIC  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Adult Glioblastoma;Age;aged;Amino Acids;anti-PD-1;anti-PD-L1;anti-PD1 therapy;Antibodies;antigen detection;Antigen Presentation;antigen-specific T cells;Antigens;Biopsy;Brain;Brain Neoplasms;brain tissue;Cancer Etiology;Cancer Vaccines;Cessation of life;chemokine;chemotherapy;Chemotherapy and/or radiation;Child;Childhood Brain Neoplasm;Childhood Glioma;Clinical;CSF3 gene;cytokine;cytokine release syndrome;Cytomegalovirus;Data;Diagnosis;diffuse midline glioma;Disease;effector T cell;Eligibility Determination;Enrollment;Ependymoma;Epitopes;Excision;Funding;Generations;Glioblastoma;Glioma;Granulocyte-Macrophage Colony-Stimulating Factor;HLA-A2 Antigen;Human;IL8 gene;Image;immune checkpoint blockade;Immune response;immunogenicity;Immunologic Adjuvants;Immunotherapeutic agent;Immunotherapy;improved;Institution;Interferon Type II;Interleukin-10;Interleukin-2;Knowledge;Laboratories;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Methods;Modeling;molecular subtypes;Montanide ISA-51;Morbidity - disease rate;mouse model;Newly Diagnosed;novel;Operative Surgical Procedures;Pathology;Patients;Peptide Vaccines;Peptides;Phase I Clinical Trials;phase I trial;phase II trial;Pilot Projects;pre-clinical;Proteins;Quality of life;Radiation;Recurrence;Regulatory T-Lymphocyte;Resected;response;Sample Size;Sampling;Solid Neoplasm;Specimen;standard care;Subgroup;synergism;T cell response;T-Lymphocyte;Tissues;TNF gene;Toxic effect;Transgenic Organisms;treatment response;tumor;Vaccines;young adult

PROJECT_TITLE: Expanding CMV peptide vaccine with novel combinations and pathologies

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Diabetes;Kidney Disease;Nutrition;Physical Activity;Prevention;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE  A cancer diagnosis is a “teachable moment” – a time when an individual may be open to behavior change – but few studies have considered modifiable lifestyle factors that might improve disease-specific survival in individuals diagnosed with renal cell carcinoma (RCC). We propose to comprehensively investigate the roles of dietary patterns and physical activity in RCC survival in three large, prospective cohorts with longitudinal food frequency questionnaires, physical activity assessments, and covariable data. Our findings will yield a foundation for developing evidence-based lifestyle recommendations for RCC survivors.

PI_NAMEs: GRAFF, REBECCA ELIZABETH;PRESTON, MARK ARTHUR (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Adherence;Behavior;behavior change;C-Peptide;cancer diagnosis;cancer survival;Cessation of life;Chronic;cohort;Cohort Studies;Collection;DASH diet;Data;diabetes control;Diabetes prevention;Diagnosis;Diagnostic;Diet;dietary;Dietary Factors;Dietary Practices;Disease;Disease Progression;Distant;evidence base;exercise intervention;experience;Follow-Up Studies;Food;Foundations;Frequencies;good diet;Grant;Health behavior;Health Care Costs;Health Care Visit;Health Professional;Healthy Eating;Hypertension;hypertension control;improved;Incidence;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Insulin;Intervention;Life Style;lifestyle factors;Malignant Neoplasms;Medical;Mendelian randomization;moderate-to-vigorous physical activity;modifiable behavior;modifiable lifestyle factors;mortality;Nephrectomy;Non-Insulin-Dependent Diabetes Mellitus;Nonmetastatic;Nurses' Health Study;Obesity;Outcome;Pathogenesis;Patients;Pattern;Personal Satisfaction;Physical activity;Positioning Attribute;Prospective cohort;Quality of life;Questionnaires;randomized trial;Recommendation;Recurrence;Renal Carcinoma;Renal Cell Carcinoma;Research;Risk;Risk Factors;Role;sedentary lifestyle;Smoking;survival outcome;Survivors;System;Time;Tumor Markers;Tumor Tissue;United States;years of life lost

PROJECT_TITLE: Informing Lifestyle Recommendations for Kidney Cancer Survival: Investigating the Role of Dietary Patterns and Physical (In)activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


NIH_SPENDING_CATS: Immunotherapy;Lung;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Inflammation and scarring of the lung is a leading cause of death among patients with autoimmune disorders, but efforts to reduce the mortality burden of this condition have been limited by a lack of effective anti-fibrotic treatments. The proposed research will define B cell-mediated pathways that contribute to the development of pulmonary fibrosis in patients with chronic graft-versus-host disease (cGVHD), an autoimmune-like condition that occurs in patients who undergo allogeneic stem cell transplantation. Knowledge gained from this study will accelerate the development of targeted immune therapies to improve the lives of patients with cGVHD and autoimmune lung disease while simultaneously fostering the career of a physician investigator committed to an independent research career in immunology.

PI_NAMEs: BRACKEN, SONALI JAGDISH (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Address;Allogenic;Anti-Inflammatory Agents;antifibrotic treatment;Autoimmune;Autoimmune Diseases;Autoimmunity;Award;B cell therapy;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Biological Assay;Biopsy;Bone Marrow Transplantation;Bronchiolitis Obliterans;career;career development;Cause of Death;CD44 gene;Cells;Cessation of life;Chemotaxis Induction;chronic graft versus host disease;Clinical;Coculture Techniques;Connective Tissue Diseases;cytokine;Data;Data Analyses;Deposition;design;Development;Disease;Doctor of Philosophy;Event;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;fibrotic lung;Fostering;Foundational Skills;Future;Goals;Health;Hematopoietic Stem Cell Transplantation;Human;Hyaluronan;Hyperactivity;Immune;Immune Targeting;Immunofluorescence Microscopy;Immunologics;Immunology;Immunotherapy;improved;In Vitro;Inflammation;Inflammatory;insight;Interferon Receptor;Interferons;Interleukin-6;Interstitial Lung Diseases;Investments;K-Series Research Career Programs;Knowledge;Laboratories;Ligands;Longevity;Lung;Lung Diseases;Lung Transplantation;Mediating;Mediator;Mentorship;Molecular;Molecular Weight;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;novel;Organ;Pathogenesis;Pathologic;Pathway interactions;Patients;Physicians;Population;Positioning Attribute;Production;Prognosis;programs;Pulmonary Fibrosis;receptor;Receptor Signaling;Research;Research Personnel;Research Training;Resources;Respiratory Failure;response to injury;rheumatologist;Role;Sampling;Scientist;Severities;Severity of illness;Signal Pathway;Signal Transduction;skills;Stem cell transplant;Structure of parenchyma of lung;Syndrome;Systemic Scleroderma;targeted treatment;Techniques;therapeutic target;Tissue Sample;TLR7 gene;Toll-like receptors;Training;transcription factor;Universities;Work

PROJECT_TITLE: B Cell-Fibroblast Crosstalk Promotes Chronic GVHD of the Lung

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: LUNA LABS USA, LLC

ORG_STATE: VA

PHR: Project Narrative The elicitation of broadly neutralizing antibodies (bNAbs) against Tier 2 neutralization resistant HIV-1 viruses has proven extremely difficult to achieve by vaccination. Evidence to-date suggests that no individual factor will determine the ultimate success of an HIV-1 vaccine. The goal of this program is to overcome challenges with HIV-1 vaccination through the codelivery of an Env-trimer-modified and mRNA-modified carbon nanotube targeting both humoral and cellular immune responses.

PI_NAMEs: XU, YANG  (contact)

PROJECT_TERMS: Address;Adjuvant;ADME Study;Affinity;analytical method;Antibodies;Antigenic Variation;Antigens;arm;B-Lymphocytes;Binding;biomaterial compatibility;Biotechnology;Carbon Nanotubes;CD8-Positive T-Lymphocytes;CD8B1 gene;Certification;Chemistry;Clinical;Clinical Research;clinical translation;Collaborations;cost;cost effective;design;Development;efficacy study;Ensure;Epitopes;Formulation;gang;gene transfer vector;Generations;Glycoproteins;Goals;HIV;HIV resistance;HIV vaccine;HIV-1;HIV-1 vaccine;humanized mouse;Immune response;Immune system;immunogenic;immunogenicity;In Vitro;in vivo;Individual;Infection;Injectable;Injections;Intramuscular;lipid nanoparticle;Macaca mulatta;manufacture;manufacturing process;manufacturing scale-up;Mediating;Messenger RNA;Methodology;Methods;Modeling;Modification;Molecular Conformation;mouse model;mRNA delivery;mRNA Instability;nanovaccine;neutralizing antibody;nonhuman primate;novel;pandemic disease;Peptides;Persons;Phase;Physiological;Polysaccharides;pre-Investigational New Drug meeting;preclinical study;predicting response;preservation;Process;Production;programs;Radiolabeled;Recombinants;Research;response;Retroviridae;RNA vaccine;Safety;scale up;Specific qualifier value;Structure;Subunit Vaccines;success;Surface;Synthetic Antigens;System;T cell response;T-Lymphocyte;Technology;Testing;Time;Toxic effect;Translations;transmission process;Universities;Vaccination;vaccine candidate;vaccine delivery;vaccine development;vaccine discovery;vaccine formulation;vaccine platform;Vaccines;Validation;Viral reservoir;Virus;Work

PROJECT_TITLE: Carbon Nanotube Enabled Delivery of mRNA for an HIV Vaccine Candidate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-U(11)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: MENLO PARK

ORG_NAME: SUBTLE MEDICAL, INC.

PHR: Narrative The proposed project seeks to develop and validate a software product capable of enhancing an entire brain magnetic resonance imaging (MRI) study. Brain studies make up approximately 20% of all MRI studies worldwide, and nearly all brain studies acquire multiple image contrasts to obtain complementary information. It has been reported that nearly 60% of all MRI acquisitions contain at least minimal motion artifacts. A successful completion of this project will result in a tool for imaging centers that will improve the consistency and quality of brain MRI studies and allow them to increase their throughput by removing the need to rescan acquisitions with artifacts.

PI_NAMEs: ZHOU, ZECHEN  (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Abbreviations;Acceleration;Age;Brain;Brain imaging;brain magnetic resonance imaging;Caring;Cohort Studies;Collaborations;Computer software;contrast imaging;deep learning;deep learning model;denoising;Diagnostic;diagnostic value;Equipment;experience;forgetting;Frequencies;Growth;Health system;Image;Imaging Device;imaging facilities;imaging study;improved;machine learning method;Magnetic Resonance Imaging;Medical;medical specialties;Modeling;Morphologic artifacts;Motion;operation;Output;Patient Care;Patients;Phase;Population;Protocols documentation;Quality of Care;radiologist;Radiology Specialty;Reporting;Scanning;Services;Specialist;System;Time;tool;trend;ultra high resolution;United States;Universities;Washington

PROJECT_TITLE: Automated enhancement and correction of brain MRI images that leverages the entire imaging exam


NIH_SPENDING_CATS: Ataxia Telangiectasia;Brain Disorders;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases

PHR: Project Narrative Ataxia telangiectasia (A-T) is a genetic condition causing nerve damage, weakened immunity, and higher cancer risks due to certain protein mutations. Our research explores a new, less harmful treatment method using specially designed toxins in mouse models, aiming to improve immunity, reduce cancer risk, and curb inflammation in A-T patients.

PI_NAMEs: CHANDRAKASAN, SHANMUGANATHAN  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Ablation;Acceleration;Address;Alkylating Antineoplastic Agents;Alleles;Allogenic;Antibodies;antibody conjugate;Ataxia;Ataxia Telangiectasia;Ataxia Telangiectasia Patients;Attenuated;Brain;cancer risk;Cerebellar degeneration;Cessation of life;chemokine;chemotherapy;Child;Chimerism;Chronic;conditioning;cytokine;Death Rate;design;Development;DNA Damage;DNA Maintenance;DNA Repair;Environment;experience;Gait;Genetic Diseases;genome integrity;Genomics;Genotoxic Stress;genotoxicity;High-Risk Cancer;Immune;immune function;immune reconstitution;Immunity;Immunocompetent;immunodeficiency;Immunotoxins;improved;infection risk;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Ionizing radiation;Link;Lymphocytic choriomeningitis virus;Lymphoma;Methods;Modeling;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;nerve damage;Nerve Degeneration;Neurologic;Neurological outcome;Outcome;Pathologic;Patients;Peripheral;peripheral blood;Phenotype;Poly I-C;Proteins;Proto-Oncogene Protein c-kit;PTPRC gene;Publishing;Qualitative Evaluations;Quantitative Evaluations;Recombinants;Regimen;Reporting;Research;Risk;Role;Spleen;Sterility;Stress;stressor;Telangiectasis;Therapeutic;Thymus Gland;Tissues;Toxin;Transplantation;vaccine immunogenicity

PROJECT_TITLE: Non-genotoxic HSCT for ATM

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


ADMINISTERING_IC: OH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: This project delves into the realm of Human-Robot Collaboration (HRC) within the construction industry using Virtual Reality (VR) and wearable devices as tools, aiming to determine the impact of levels of involving human-robot collaborations in construction on workers' (both male and female) cognitive risk factors (including mental fatigue, attention, and stress) to enhance occupational safety and health. Neglecting the understanding and analysis of cognitive risk factors in HRC can lead to unforeseen safety hazards and health issues and further hinder the successful adoption and efficiency of HRC in construction. At the completion of the proposed research, the outcomes are expected to not only offer strong evidence to enhance safety measures and worker well-being and promote effective HRC implementations, but also posit that the strategic integration of robotics in construction tasks can foster a broader, more inclusive construction working environment and alleviate workforce shortages, promoting the public well-being.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Human-Robot Collaboration in Construction: Assessing Cognitive Factors for Construction Workers Using Virtual Reality-Wearable Devices-Data Analytics Integrated Approach

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Obesity affects nearly half of Americans and is a risk factor for stroke, heart attack, and Type II diabetes. This investigation aims to uncover the signals that promote homeostasis in the visceral adipose tissue, which is intimately related to the adverse health effects of obesity. The findings will enhance our knowledge of the mechanisms promoting obesity and diabetes-related inflammation and inform the development of therapeutics to treat this inflammation and reduce or prevent obesity and diabetes-related adverse health outcomes.

PI_NAMEs: BALCEREK, JOANNA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: 3-Dimensional;Adipocytes;Adipose tissue;Adult;Advisory Committees;Affect;American;angiogenesis;Animal Feed;Animals;antibody conjugate;Appearance;Architecture;Award;Biological Response Modifiers;Biometry;Blood capillaries;Cardiovascular Diseases;Cardiovascular system;career development;Cell Therapy;Cells;Cellular Immunity;Central obesity;Characteristics;Chronic;Clinical Pathology;Collaborations;Collagen;Confocal Microscopy;Crowns;cytokine;Data;Data Science;Deposition;Development;Development Plans;Diabetes Mellitus;Disease;Distress;Doctor of Philosophy;Energy Intake;Environment;Epidemic;Event;Expenditure;Fatty acid glycerol esters;Fellowship;Fibroblasts;Fibrosis;Flow Cytometry;Foundations;Funding;Future;glucose tolerance;Goals;Health;Heart Arrest;helminth infection;Hematopoietic;High Fat Diet;Homeostasis;Human;Hyperglycemia;IL1R1 gene;IL4R gene;Immune;Immunity;Immunology;immunoregulation;in vivo;Infiltration;Inflammation;Inflammatory;Insulin Resistance;Interleukin-1;Interleukin-13;Interleukin-4;Interleukin-6;Investigation;Knock-out;Knowledge;Link;LoxP-flanked allele;Lymphocyte;Lymphoid;Lymphoid Cell;Macrophage;Measures;Mentorship;Metabolic;Metabolic dysfunction;Molecular;multidisciplinary;multimodality;Mus;Myocardial Infarction;Myofibroblast;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese person;Obesity;obesity development;obesity management;obesity prevention;obesity treatment;Outcome;Overnutrition;Pathologic;Peritoneal;Physicians;Population;Profibrotic signal;programs;Proliferating;promoter;PTPRC gene;receptor;Regulatory T-Lymphocyte;Research;Research Ethics;Residencies;response;Risk Factors;Sampling;Scientist;Signal Transduction;Stroke;Structure;Surface;Surveys;T cell infiltration;tertiary lymphoid organ;Testing;therapeutic development;therapeutic target;Thick;Thinness;Time;Tissue Expansion;tissue mapping;Tissues;Training Programs;transfusion medicine;United States National Institutes of Health;Visceral;Weight;Work

PROJECT_TITLE: Control of adipose immune-stromal niche topography in obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M3)]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: The premise of this study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra-indications and side effects, is real time, and noninvasive helping physicians to evaluate the result of UAE procedures. Also, this study will evaluate uterine fibroid pressures using SHAPE, comparing the results with normal myometrium tissue in order to determine its characteristics and tissue differences, which we believe will lead to the development of a new biomarker for the diagnosis and treatment of uterine fibroids.

PI_NAMEs: GONSALVES, CARIN F;MACHADO, PRISCILLA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Acoustics;Address;Affect;African American Women;Agreement;Arteries;Benign;Biological Markers;Blood flow;Blood Vessels;Characteristics;Clinical;clinical diagnosis;clinically significant;contrast enhanced;Contrast Media;cost;Development;Diagnosis;diagnostic accuracy;efficacy evaluation;elastography;Enrollment;Evaluation;Fibroid Tumor;follow-up;Frequencies;Gadolinium;Goals;Hysterectomy;Image;imaging modality;improved;Individual;infection risk;Insurance;Lesion;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Maps;Measurement;Measures;Methods;Microbubbles;Multicenter Trials;myometrium;novel marker;Outcome;Patients;Pattern;Physicians;Pilot Projects;Portal Hypertension;Portal Pressure;pressure;Procedures;Quality of life;Reader;research clinical testing;Role;second harmonic;side effect;Signal Transduction;Site;Smooth Muscle Myocytes;Specificity;standard of care;Symptoms;Techniques;Therapeutic Embolization;Time;Tissues;Transducers;Translating;transmission process;Treatment Efficacy;tumor;Ultrasonography;ultrasound;United States;United States National Institutes of Health;Uterine Fibroids;Uterine Monitoring;Uterine myomectomy;Uterus;Vascular blood supply;Vascularization;White Women;Woman

PROJECT_TITLE: Evaluation of Uterine Fibroids by Contrast Enhanced Ultrasound (CEUS) and Subharmonic-Aided Pressure Estimation (SHAPE) Pre and Post Uterine Artery Embolization (UAE)

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Summary/Abstract: One of the keys to reduce the significantly higher prostate cancer mortality of African American (AA) men is effective, minimally invasive early detection of disease. We will determine the sensitivity and specificity of two innovative next generation sequencing (NGS)-based methods, one based on the fragmentomics profiles and one based on methylation profiles of plasma derived cell free DNA, to detect prostate cancer of various disease stages. This will establish a non-invasive method for the early detection of PCa of AA men.

PI_NAMEs: SZALLASI, ZOLTAN  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: advanced disease;African American;African American population;American;Benchmarking;Biopsy;cancer health disparity;Cancer Patient;cell free DNA;Cells;Clinical;Detection;detection method;Diagnosis;Diagnostic Procedure;Disease;Disease Progression;DNA Fragmentation;DNA Methylation;Early Diagnosis;European;Face;follow-up;Frequencies;Genome;genome sequencing;high risk men;High-Throughput Nucleotide Sequencing;Immunoprecipitation;improved;innovation;Liquid substance;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;Methods;Methylation;methylation pattern;minimally invasive;mortality;next generation sequencing;No Evidence of Disease;Operative Surgical Procedures;Outcome;Patients;Pattern;Plasma;Protocols documentation;Sampling;Screening for Prostate Cancer;Sensitivity and Specificity;Surgical Pathology;Time;whole genome

PROJECT_TITLE: Reducing prostate cancer mortality in African American men by early disease detection using DNA fragmentation profiles and methylated DNA patterns of plasma derived cell free DNA

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Lysosomal storage disease is a collection of 70 monogenic diseases that affect 1 in 5000 live births. Most of these diseases have no treatment. This study investigates a new immune protein that can be targeted to treat many lysosomal storage diseases.

PI_NAMEs: YAN, NAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affect;antagonist;Behavior;Biogenesis;Brain;Breeding;Cells;Clinical;Collection;Disease;Disease Progression;DNA Sequence Alteration;early onset;Enzymes;Fluorescence Microscopy;Functional disorder;Gene Expression;Genes;Homeostasis;Immune;immune activation;Immune signaling;Immune Targeting;Impairment;Inflammation;Inflammatory;inhibitor;innate immune pathways;Interferon Type I;IRF3 gene;Kinetics;knock-down;Live Birth;Lysosomal Storage Diseases;Lysosomes;Macrophage;Measures;Mediating;Mendelian disorder;Mitochondria;Molecular;motor disorder;mouse model;Mus;Nature;Nerve Degeneration;neuroinflammation;neuropathology;new therapeutic target;Niemann-Pick Diseases;novel;NPC1 gene;Onset of illness;Pathogenesis;Pathology;Peripheral;pharmacologic;Play;preclinical study;Proteins;Role;Signal Pathway;Signal Transduction;Signaling Protein;Small Interfering RNA;Testing;TFE3 gene;Time;Tissues;trafficking;transcription factor;Treatment Efficacy;Wild Type Mouse

PROJECT_TITLE: The Role of Sting in Lysosomal Storage Disorder

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Electronic cigarettes have exploded in popularity amongst adolescents, renormalizing tobacco use in non- smoking adolescents, and increasing risk for tobacco smoking, other drug use, and direct negative health effects of vapor exposure. Amidst growing demand for adolescent vaping cessation interventions where no proven treatment exists, we have developed QuitVaping, a scalable, fully-remote, young adult lay counselor delivered intervention with digital content that is well accepted and showing promise for vaping cessation in adolescents who vape nicotine daily. This project will determine whether QuitVaping is effective for vaping cessation in mid to late adolescents who vape nicotine at least weekly.

PI_NAMEs: EVINS, A EDEN (contact);SCHUSTER, RANDI MELISSA

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Abstinence;addiction;Address;Adherence;Adolescent;adolescent smoking;adolescent substance use;Advertising;Age;Alcohol consumption;Alcohols;Behavior Therapy;Behavioral;behavioral health;Biochemical;Blinded;Cannabis;care systems;Cellular Phone;Cigarette;Clinical;clinical care;Clinical Trials;Cognitive;combat;community setting;Consensus;Cotinine;Data;Dependence;design;Development;digital;digital intervention;Double-Blind Method;Drug Addiction;Drug Prescriptions;Drug Screening;Drug usage;drug use vulnerability;Early Intervention;Education;effective intervention;effective therapy;efficacy testing;Electronic cigarette;Electronic Nicotine Delivery Systems;emotion regulation;Emotional;Engineering;Enrollment;Epidemic;Exclusion;Exclusion Criteria;Explosion;Family;follow-up;Future;Health;Health Personnel;high risk;high school;Home;hookah;improved;Incentives;innovation;Intervention;meetings;Methods;Monitor;Nicotine;Nicotine Dependence;non-smoking;Oral Tobacco;Patient Self-Report;Pattern;Pharmaceutical Preparations;Population;Positioning Attribute;Prevalence;prevent;Professional counselor;progression risk;psychoeducation;Public Health;Randomized, Controlled Trials;remote intervention;Reporting;retention rate;Risk;Sampling;satisfaction;School-Age Population;Schools;Severities;skills;smartphone application;smoking cessation;snuff;social;social media;substance use;Substance Use Disorder;Surveys;Symptoms;Testing;texting support;theories;Time;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;tobacco products;Tobacco smoke;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;treatment as usual;twelfth grade;vaping;vaping nicotine;vapor;Visit;young adult;Youth

PROJECT_TITLE: Remote, Young Adult Lay-Counselor Delivered Behavioral and Digital Intervention for Youth to Promote Vaping Cessation and Prevent Escalation of Tobacco Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In the face of increasing resistance to frontline antimalarials, there is a critical need for new drugs that can act against both human and mosquito stages of malaria infection. The highly divergent mitochondrion of the malaria parasite is an attractive drug target, but harnessing its full potential requires in-depth understanding of the organelle’s biology and metabolic pathways. This project aims to identify core functions of the mitochondrion that are likely to be essential across all life stages of the parasite.

PI_NAMEs: RAJARAM, KRITHIKA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Anti-malarials;Applications Grants;atovaquone;Binding;Biology;Blood;Bypass;chemotherapy;Client;Clinical;Coenzyme A;cofactor;cohort;Complex;Culicidae;Dependence;Development;Dihydroorotate dehydrogenase;Disease;Drug resistance;Drug Targeting;Electron Transport;Enzymes;Exhibits;Gene Expression;Generations;Genes;Genetic;Genetic Screening;Genetic Techniques;global health;Goals;Housekeeping;Human;improved;Individual;Infection;inhibitor;Investigation;Iron;IscS protein;Libraries;Life;Life Cycle Stages;Liver;Maintenance;Malaria;malaria infection;Maps;Membrane Potentials;Metabolic;Metabolic Pathway;Methods;Mitochondria;mitochondrial membrane;Mitochondrial Proteins;Molecular Target;mortality;Mutagenesis;mutant;new therapeutic target;novel therapeutic intervention;novel therapeutics;Nuclear;Organelles;Parasites;Pathway interactions;Persons;Pharmaceutical Preparations;Plasmids;Plasmodium;Plasmodium falciparum;prevent;Process;programs;Property;prophylactic;Proteins;Proteome;Pyrimidine;Recycling;Reporter;Research;Resistance;resistant Plasmodium falciparum;response;reverse genetics;Role;Route;Source;Sulfur;System;Techniques;tool;Transfection;transmission blocking;transmission process;Ubiquinone;Update

PROJECT_TITLE: Essential functions of the mitochondrion in malaria parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]