NIH_SPENDING_CATS: Biotechnology;Cancer;Cannabidiol Research;Cannabinoid Research;Natural Products;Therapeutic Cannabinoid Research

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE If this work demonstrates that CBD interacts specifically with signaling pathways relevant to targeted cancer therapies, this result would strongly imply that use of CBD by individuals with cancer, either prior to diagnosis, or during or after treatment with targeted therapies, could significantly affect disease prognosis, response to treatment, or likelihood of disease recurrence. Such interactions could add a previously unappreciated variable to the performance of clinical trials for new cancer therapeutics. In addition, should CBD be found to synergize with clinically useful drugs currently used or under investigation for cancer therapy, the proposed work may provide the basis for preclinical and clinical studies to advance innovative new combination treatments involving CBD.

PI_NAMEs: GOLEMIS, ERICA A. (contact);WARD, SARA J

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Affect;Aftercare;antagonist;Area;Bioinformatics;Biological Assay;Breast Cancer Cell;cancer care;Cancer Cell Growth;Cancer cell line;Cancer Model;cancer pain;cancer therapy;cancer type;Cannabidiol;Cannabinoids;Cannabis;Cell Death;Cell Line;Cell model;Cell Survival;chemotherapy;Cisplatin;Clinical;Clinical Research;Clinical Trials;clinically relevant;Colorectal Cancer;Combined Modality Therapy;Communities;Complement;Cytotoxic Chemotherapy;Data;data resource;Diagnosis;Disease;disease prognosis;Dose;Drug Interactions;Drug Targeting;Drug usage;Epidermal Growth Factor Receptor;Growth;Growth Factor Receptors;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Immune response;Immunotherapy;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;inhibitor;innovation;interest;Investigation;Laws;Legal;Libraries;Malignant Neoplasms;Marijuana;marijuana use;Measurement;Mediator;Modeling;novel;novel therapeutic intervention;Nuclear;Outcome;Outcome Assessment;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;Pattern;Perception;Performance;Pharmaceutical Preparations;Phase;Phosphotransferases;Phytochemical;Pilot Projects;preclinical study;Prognosis;Protein Analysis;Protein Array Analysis;Proteins;Proteomics;Publishing;receptor;receptor expression;Recording of previous events;Recurrent disease;Relaxation;Research;Resistance;response;screening;Signal Pathway;Signal Transduction;Signaling Protein;social stigma;Solid Neoplasm;Somatic Mutation;Source;spheroids;Stigmatization;synergism;Systemic Therapy;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapeutic target;therapy outcome;treatment response;tumor;tumor growth;United States;Variant;Work;Xenograft procedure

PROJECT_TITLE: Interaction of cannabidiol (CBD) with targeted inhibitors of essential cancer signaling pathways


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: RICHARDSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Narrative  Kidneys, as a major organ for waste removal, are being exploited to accelerate the body clearance of “off-target” engineered nanoparticles to meet FDA regulation for the clinical translation of nanomedicines, which demands thorough understanding of nanoparticle transport and interactions at the fundamental level. However, renal proximal tubule is often overlooked in comparison with extensive studies on glomerular filtration of engineered nanoparticles even though proximal tubule is the most active site involved in concentration, retention and reabsorption of the filtered proteins through glomeruli. In this application, we aim to fundamentally understand the size, charge and surface-chemistry dependencies in the transport and interactions of ultrasmall engineered nanoparticles in both normal and injured proximal tubules, laying down a foundation for developing kidney-safe nanomedicines that can be used in clinics.

PI_NAMEs: YU, MENGXIAO  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: absorption;Acceleration;Active Sites;Animals;Artificial nanoparticles;base;biomaterial compatibility;Cells;cellular microvillus;Charge;Chemistry;Cisplatin;Clinic;clinical application;clinical translation;Dependence;design;Development;Disease;Electron Microscopy;Electrons;Excision;Foundations;Future;glomerular filtration;Health Hazards;imaging probe;Imaging Techniques;in vivo;injured;Injury;Injury to Kidney;Investigation;Kidney;Kidney Diseases;kidney dysfunction;Libraries;microscopic imaging;mouse model;Multimodal Imaging;Mus;nanoGold;nanomedicine;nanoparticle;nanoscale;Nanotechnology;Nature;nephrotoxicity;Optics;Organ;Patients;Proteins;Proximal Kidney Tubules;Regulation;Renal function;Renal tubule structure;Rodent Model;Roentgen Rays;Site;Solid;Staging;Structure;success;Surface;Translating;Tubular formation;Visit;wasting

PROJECT_TITLE: Unravel Nanoparticle Transport and Interactions in Renal Proximal Tubules

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PI_NAMEs: PASCHE, BORIS  (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Baptist Church;Basic Science;Calendar;Cancer Center Support Grant;Charge;clinical investigation;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;Comprehensive Cancer Center;Development;Extramural Activities;Fostering;Funding;Funding Mechanisms;Goals;Grant;health disparity;innovation;interdisciplinary collaboration;interest;investigator-initiated trial;Investments;Leadership;Link;National Cancer Institute;National Clinical Trials Network;Pilot Projects;Population Sciences;precision medicine;Recurrence;Request for Applications;Research;Research Personnel;Research Project Grants;Research Support;Resources;Strategic Planning;survivorship;therapy resistant;Tobacco;Translational Research;Wages

PROJECT_TITLE: Developmental Funds

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Advisory Committees;anti-cancer research;Baptist Church;Bioinformatics;Bioinformatics Shared Resource;Biological Sciences;Biometry;Budgets;Cancer Center Support Grant;cancer genomics;cancer research center director;cellular engineering;Charge;Collaborations;Complex;Comprehensive Cancer Center;Consultations;cost effective;cost effectiveness;Crystallography;Data Analyses;Development;Doctor of Philosophy;Educational workshop;empowerment;Ensure;Equipment;equipment acquisition;Evaluation;experience;Experimental Designs;Faculty;Feedback;Fees;Flow Cytometry;Fostering;Funding;Goals;Individual;Infrastructure;instrument;instrumentation;inter-institutional;Laboratories;Leadership;Maintenance;Malignant Neoplasms;member;Mentors;metabolomics;Mission;multiple omics;next generation;novel;operation;Patient Outcomes Assessments;Performance;Phase;Play;Policies;Productivity;programs;Proteomics;Publications;Qualifying;Reporting;Research;Research Personnel;Resource Sharing;Role;Scientist;service delivery;Services;System;Technology;Training;Training and Education;transcriptomics;translational study;Tumor Pathology;Tumor Tissue;Update;Vision

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Public Health Relevance Statement The neural crest is a multipotent stem-cell population that forms an amazingly diverse set of derivatives, including neurons and glia of the craniofacial skeleton, peripheral nervous system, skin melanocytes, and portions of the heart. Because they are involved in many birth defects, including cleft lip and palate, and cancers (e.g. melanoma, neuroblastoma), our results on their normal development will yield important clues regarding mistakes causing abnormal development and tumors.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Amaze;Anterior;Biological Assay;bisphosphonate;bone;Bone necrosis;Branchial arch structure;candidate identification;Cartilage;Cell Differentiation process;cell type;Cells;Cephalic;Characteristics;Chick Embryo;Chondrocytes;Chromatin;Cleavage Under Targets and Release Using Nuclease;cleft lip and palate;comparative;Complex;Congenital Abnormality;Coupled;craniofacial;CRISPR/Cas technology;Development;Ectopic Expression;Electroporation;Embryo;embryonic stem cell;Endowment;Enhancers;Environment;Face;face bone structure;Ganglia;Gene Expression Profiling;gene regulatory network;Genes;Genetic Transcription;Genomic approach;Goals;Grant;Head;Heart;In Situ Hybridization;in vivo;insight;Knock-out;Link;long bone;Malignant Neoplasms;Mediating;melanocyte;Melanoma;Mesoderm;migration;Morphology;Multipotent Stem Cells;Neural Crest;Neural Crest Cell;neural plate;Neuroblastoma;Neuroglia;Neurons;neuroregulation;Pathway interactions;Pattern Formation;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Population;programs;public health relevance;Regulatory Element;Reporter;Resolution;response;Sensory Ganglia;Series;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Skeleton;Skin;Specific qualifier value;stem cell population;Testing;Time;transcription factor;transcriptomics;Transplantation;Transposase;tumor;Validation;vertebrate embryos;Work

PROJECT_TITLE: Gene regulatory network controlling neural crest derived formation of facial cartilage

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Cancer;Rural Health

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;Advocate;anti-cancer research;Appalachian Region;Articulation;Baptist Church;Benchmarking;Bioinformatics Shared Resource;biomedical scientist;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer genomics;Cancer health equity;cancer research center director;Catchment Area;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Health Education;Community Networks;Community Outreach;Comprehensive Cancer Center;Development;Doctor of Philosophy;Educational Activities;Environment;Evaluation;Faculty;Feedback;Fostering;Funding;Future;Goals;Health Personnel;Historically Black Colleges and Universities;improved;Incidence;Infrastructure;innovation;Innovative Therapy;Institution;inter-institutional;International;Leadership;Linguistics;Location;Malignant Neoplasms;member;Mission;Monitor;Morbidity - disease rate;mortality;next generation;operation;Patient Outcomes Assessments;Patients;Phase;Pilot Projects;Prevention strategy;Process;Productivity;programs;Protocols documentation;Qualifying;Recommendation;recruit;Research;Research Activity;Resource Sharing;Resources;Rural;skills;Strategic Planning;Strategic vision;Structure;success;System;Training;Training and Education;Translational Research;translational scientist;Translations;Tumor Pathology;Tumor Tissue;United States;Update;Vision

PROJECT_TITLE: Leadership, Planning, and Evaluation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Precision Medicine

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question “can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?”

PI_NAMEs: MONFILS, MARIE H.;SMITS, JASPER  (contact);TELCH, MICHAEL J.

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;Aftercare;Algorithms;Animals;Anxiety;Anxiety Disorders;anxiety treatment;anxiety-related disorders;Area;Basic Science;Benchmarking;Biological Assay;Biological Markers;biomarker identification;biomarker performance;biomarker selection;Boston;Carbon Dioxide;Classification;Clinic;Clinical;Clinical assessments;clinical practice;Data;design;Development;Diagnosis;Diagnostic;Disease;Disease remission;DSM-V;effective therapy;Elements;Enrollment;Exposure to;Extinction;follow-up;Fright;Future;Genotype;Goals;Human Resources;Hypercapnia;Hyperventilation;hypocretin;Impairment;improved;indexing;Intervention;Investigation;Link;Measures;Mediating;meetings;Middle Hypothalamus;Modeling;National Institute of Mental Health;Neurons;novel marker;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Panic Disorder;Participant;Patients;personalized medicine;Phenotype;Plasma;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;predictive modeling;Predictive Value;Procedures;productivity loss;prognostic;prospective;Protocols documentation;Proxy;Public Health;Rattus;receptor;Recovery;Research;Resources;respiratory challenge;response;ROC Curve;Rodent;Role;Saliva;Sample Size;Sampling;Selection for Treatments;Severities;Signal Transduction;Site;sound;Specificity;Speed;Strategic Planning;stressor;Structure;Symptoms;System;Testing;Translating;translation to humans;Translations;Trauma;Treatment Cost;treatment strategy;Work

PROJECT_TITLE: 1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based Therapy


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adult;Baptist Church;Cancer Center Support Grant;Cancer health equity;Catchment Area;central database;Child;Clinical Cancer Center;Clinical Data;Clinical Practice Guideline;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Communities;Complex;Comprehensive Cancer Center;COVID-19 pandemic;Data;data integrity;data management;Dedications;Directories;Discipline of Nursing;Disease;early phase clinical trial;Education;Electronics;Elements;Enrollment;Ensure;ethnic minority;Good Clinical Practice;Grant;Hispanic;human old age (65+);Individual;Informed Consent;Intervention;Intervention Studies;Leadership;Life Cycle Stages;life span;meetings;Minority Health Research;Modeling;Monitor;Nursing Research;Operations Research;participant safety;patient safety;patient screening;Patients;Performance;Physician Executives;Policies;Process;Protocol Compliance;protocol development;Protocols documentation;Quality Control;racial minority;recruit;Regulation;Reporting;Research;Research Personnel;research study;Resources;Risk;Role;Safety;Science;Services;System;Translational Research;Translations;treatment trial;United States National Institutes of Health;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Patient Safety

PROJECT_TERMS: Accountability;Adult;anti-cancer research;authority;Baptist Church;Biometry;Cancer Center Support Grant;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Comprehensive Cancer Center;Conduct Clinical Trials;Data;data management;Dedications;design;Disease;Ensure;Evaluation;expedited review;experience;Faculty;Goals;Hematology;Individual;Industry;Institution;Institutional Review Boards;Internal Medicine;Malignant Neoplasms;Medicine;meetings;Modification;Monitor;multidisciplinary;NCI Center for Cancer Research;Oncology;Operative Surgical Procedures;Peer Review;Procedures;Process;process improvement;Productivity;professor;Protocols documentation;Qualifying;Radiation Oncology;Radiology Specialty;Research;Research Personnel;research study;Review Committee;Risk;Safety;Social Sciences;sound;Surgical Oncology;System

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The anesthetic ketamine is efficacious as a fast-acting antidepressant in patients with treatment refractory major depression, but its potential for long-term antidepressant use is limited by its abuse potential and capacity to produce dissociative effects. Ketamine is rapidly metabolized to a number of biologically active metabolites that are pharmacologically distinct from ketamine, including (2R,6R)-hydroxynorketamine, which in preclinical models, shares ketamine’s therapeutic effects without its side effects. We propose to utilize preclinical models including electrophysiological characterization of brain synapse function to further determine the relevant antidepressant- and side-effect profiles of ketamine’s hydroxynorketamine metabolites, which will lead to important mechanistic insights relevant to the development of next generation fast-acting antidepressants.

PI_NAMEs: GOULD, TODD D (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: abuse liability;Acute;Adverse effects;Affinity;Anesthetics;Anhedonia;antagonist;anti-depressive agents;antidepressant effect;Behavioral;Behavioral Assay;Biological;Brain;Brain-Derived Neurotrophic Factor;Calcium;Clinical;Cyclic AMP;Data;depressive symptoms;Development;Disease remission;Drug abuse;drug development;drug discovery;Drug Kinetics;Electrophysiology (science);experience;experimental study;Feeling suicidal;Fiber;Funding;Future;Glutamates;Goals;Hippocampus;Human;improved;In Vitro;in vivo;Individual;Innovative Therapy;insight;Ketamine;Knowledge;Major Depressive Disorder;Measurement;Measures;Mediating;Mental Depression;Metabolism;Moods;Mus;N-Methyl-D-Aspartate Receptors;neurochemistry;Neurons;Neuropharmacology;Neurosciences Research;next generation;norketamine;novel;novel therapeutics;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Phase;phase II trial;Photometry;Plasma;Population;Pre-Clinical Model;preclinical study;Preparation;presynaptic;Probability;Property;Publishing;Receptor Inhibition;Refractory;Research;Resistance;Role;safety study;side effect;Slice;Stereoisomer;Structure;Structure-Activity Relationship;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synthesis Chemistry;therapeutic development;Therapeutic Effect;translational neuroscience;Treatment Efficacy;Work

PROJECT_TITLE: Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

PROJECT_TERMS: Administrative Supplement;Alternative Splicing;American Association of Cancer Research;anti-cancer research;Applications Grants;ATAC-seq;Baptist Church;Behavior;Big Data;Binding;Bioinformatics;Bioinformatics Shared Resource;Biological;Biometry;Biostatistics Shared Resource;cancer cell;Cancer cell line;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Infrastructure;Cell Line;Cells;Chromosomes;Clinical Data;Clinical Research;Clinical Trials;Cloud Computing;community engagement;Community Outreach;Complex;Comprehensive Cancer Center;Computer Analysis;Consultations;cost effective;cytokine;Data;Data Analyses;data integration;data sharing;data sharing networks;data visualization;data warehouse;Databases;deep learning;Development;Disease;DNA Sequence Alteration;Doctor of Philosophy;Encyclopedias;Epigenetic Process;Event;Evolution;experimental analysis;Experimental Designs;Extramural Activities;Fatty Acids;Feedback;Foundations;Funding;Gene Expression;Gene Mutation;Generations;Genetic;GENIE;genomic data;Genomics;Goals;Grant;High Performance Computing;Hour;Image;immune cell infiltrate;Immunotherapy;improved;Informatics;Infrastructure;Institution;Intervention;Journals;Malignant Neoplasms;member;Metabolic;metabolomics;Mitochondria;Modification;mortality;multiple omics;Mutation;neoplasm registry;next generation sequencing;novel;Nucleic Acids;Outcome;Pathway interactions;Patient-Focused Outcomes;Peer Review;Population Research;Population Sciences;precision oncology;Preparation;Production;programs;promoter;Proteins;Proteomics;public database;Publications;Publishing;recruit;Research;Research Design;Research Personnel;Resource Sharing;response;RNA Splicing;sequencing platform;Services;single cell analysis;single-cell RNA sequencing;Split-Pool Ligation Transcriptome sequencing;symposium;System;targeted treatment;Technology;The Cancer Genome Atlas;therapy outcome;Time;Training and Education;transcription factor;Translating;treatment response;trend;tumor microenvironment;underserved minority;Untranslated RNA;Validation;Visualization

PROJECT_TITLE: Bioinformatics Shared Resource


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Narrative: Surgery is the most important treatment method for oral cancer, and intraoperative histopathology via frozen section is the gold standard to diagnose positive margins and to guide surgical resections. However, frozen section histopathology requires specialized equipment and expert personnel that are not available in many settings including rural US, and surgeons struggle with the need to ensure complete tumor removal while sparing normal tissue. The DeepDOF platform developed here will provide an affordable tool to rapidly examine tumor margins of large areas of fresh tissue resections, allowing precisely guided surgical resections at the point of care.

PI_NAMEs: GILLENWATER, ANN M;RICHARDS-KORTUM, REBECCA R. (contact);VEERARAGHAVAN, ASHOK

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: absorption;Address;algorithm training;Algorithms;Anatomy;Area;Artificial Intelligence;automated algorithm;cancer surgery;cancer survival;cellular imaging;Cellular Morphology;Classification;Clinical;Clinical Data;clinical infrastructure;Clinical Research;Computer Assisted;Computer-Assisted Diagnosis;Consumption;contrast imaging;cryostat;deep learning;design;Diagnosis;Diagnostic;digital;disease diagnosis;Dyes;Ensure;Equipment;Excision;experience;fabrication;fluorescence microscope;Formalin;Freezing;Fresh Tissue;Frozen Sections;Goals;graphical user interface;health care quality;Hematoxylin and Eosin Staining Method;Histology;histopathological examination;Histopathology;Human Resources;Image;Image Analysis;Image-Guided Surgery;Improve Access;improved;innovation;instrument;Lateral;learning network;light emission;Light Microscope;Lighting;low and middle-income countries;machine learning algorithm;machine learning framework;malignant mouth neoplasm;Malignant Neoplasms;Manuals;Maps;Masks;Mechanics;meter;Methods;Microscope;Microscopy;Microtome - medical device;Monitor;Mouth Neoplasms;mouth squamous cell carcinoma;Normal tissue morphology;novel;Nuclear;Operative Surgical Procedures;optical imaging;Optics;Oral Surgical Procedures;Paraffin;Pathologist;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Performance;Play;point of care;Population;Preparation;Procedures;Process;programs;Protocols documentation;reconstruction;Recurrence;research clinical testing;Resected;Resolution;Resource-limited setting;Resources;Role;Rural;Sampling;scalpel;Scanning;Services;Slice;Slide;Specific qualifier value;Specimen;Speed;Stains;Surface;Surgeon;survival outcome;Survival Rate;System;Technology;Testing;Thick;Thinness;Time;Tissue imaging;tissue processing;Tissue Sample;Tissues;tool;Training;tumor;ultraviolet;Ultraviolet Rays;Variant;virtual

PROJECT_TITLE: Deep learning microscope for slide-free and digital histology

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Award;Baptist Church;Biostatistics Shared Resource;Cancer Center Support Grant;cancer health disparity;Clinical;clinical practice;Clinical Protocols;Clinical Research Protocols;Clinical Trials;Collaborations;Comprehensive Cancer Center;cost efficient;Data;Data Analyses;design;Development;Direct Costs;Doctor of Philosophy;Education;Educational workshop;Extramural Activities;Faculty;Funding;genetic signature;Glioblastoma;Goals;Grant;health related quality of life;Hour;improved;Incidence;innovation;Investments;Laboratories;Leadership;Link;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Meta-Analysis;Metastatic malignant neoplasm to brain;Methodology;Methods;Mission;Monitoring Clinical Trials;Morbidity - disease rate;neuro-oncology;novel;nutrition;Outcomes Research;Paper;Patient Monitoring;patient population;Patients;Peer Review;Phase;precision oncology;Preparation;Program Research Project Grants;programs;protocol development;Protocols documentation;Publications;quality assurance;Research;Research Design;Research Peer Review;Research Personnel;Research Project Grants;Resources;response;Review Committee;Sampling;Services;Specialized Program of Research Excellence;Statistical Data Interpretation;Statistical Methods;Survival Analysis;symptom management;Techniques;Training;Training Support;Translating;trial design;Work

PROJECT_TITLE: Biostatistics Shared Resource


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The repair of damage to neurons in both the central and peripheral nervous systems depend on precise regulation of microtubule dynamics and tubulin post-translational modifications. An understanding of how tubulin PTMs contributes to neuronal injury repair will inspire the development of new therapeutic agents to assist in neuronal injury repair, but we first require an understanding when and where tubulin PTMs appear during the repair process. Probes to detect tubulin PTMs in living cells do not currently exist, but we have developed a pipeline to convert pre-existing monoclonal antibodies to fluorescent, single chain variable fragment (scFv) constructs that allow us to record the formation of PTMs in real-time, and will use this platform to generate a complete panel of probes so investigate the role of tubulin PTMs in neuronal development, regeneration and repair.

PI_NAMEs: GIGER, ROMAN JENO;OHI, RYOMA  (contact);VERHEY, KRISTEN J.

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Abbreviations;Acetylation;alpha Tubulin;Amino Acid Sequence;Antibodies;Antigens;Appearance;Area;Axon;axon growth;axon guidance;axon injury;axon regeneration;axonal degeneration;Axonal Transport;Axotomy;beta Tubulin;Binding Proteins;Biogenesis;Biological Assay;Biosensor;C-terminal;Cells;Central Nervous System;central nervous system injury;chemotherapy;Collaborations;Colorado;Complementary DNA;Cytoplasm;Cytoskeleton;Data;Dendrites;Detection;Development;differential expression;Distal;Dynein ATPase;Elements;Epothilones;Excision;Growth Cones;Hydrolase;Image;Immunoglobulin Fragments;Immunoglobulin G;injured;Injury;injury and repair;Kinesin;Length;Lifelong disability;Maps;Mass Spectrum Analysis;Metabolic;Microtubule Polymerization;Microtubules;Molecular Motors;Monoclonal Antibodies;Motor;Motor Neurons;Mus;Natural regeneration;Nerve;Nerve Degeneration;Nerve Fibers;nerve supply;Nervous System;Neurites;neuron development;neuron regeneration;neuronal cell body;neuronal growth;Neuronal Injury;Neurons;novel therapeutics;Organelles;Oryctolagus cuniculus;Paclitaxel;painful neuropathy;Pattern;Peptide Sequence Determination;Peripheral Nervous System;Permeability;Pharmaceutical Preparations;pharmacologic;Play;Polymers;Positioning Attribute;Post-Translational Protein Processing;Presynaptic Terminals;Process;Proteins;regeneration potential;Regenerative capacity;regenerative growth;Regulation;repaired;Research;response to injury;restoration;Retinal Ganglion Cells;retrograde transport;Reverse engineering;Role;sample fixation;Sensory;Site;spatiotemporal;Spinal Ganglia;Stretching;Synapses;Tail;Therapeutic Agents;Time;Tissues;Trauma;Tubulin;tyrosyltubulin ligase;Universities;Wallerian Degeneration;Work

PROJECT_TITLE: Development of live-cell probes to investigate tubulin post-translational modifications in neuronal regeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PROJECT_TERMS: Acceleration;American Cancer Society;anti-cancer research;Area;ATAC-seq;Automation;Award;B-cell receptor repertoire sequencing;Baptist Church;base;behavioral outcome;Bioinformatics;Bioinformatics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer health disparity;Capital Financing;Cells;Chromatin;Clinical;clinical predictors;Collaborations;Comprehensive Cancer Center;computerized data processing;Contracts;cost effective;Counseling;CRISPR library;Data Analyses;data integration;data mining;Department of Defense;Dependence;Development;DNA;Doctor of Philosophy;Education;Enrollment;Environment;Epigenetic Process;epigenome;Etiology;experience;Experimental Designs;Fee-for-Service Plans;Fostering;Foundations;Funding;Gene Expression Profiling;Genes;Genetic;Genome;genome sciences;genome sequencing;genomic profiling;Genomics;Genomics Shared Resource;Government;Grant;Growth;health disparity;Heterogeneity;Hour;Immune;Industry;Instruction;interdisciplinary collaboration;Interdisciplinary Education;Leadership;lectures;Libraries;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediation;member;Methylation;microbiome sequencing;Molecular;Multiomic Data;multiple omics;NCI Center for Cancer Research;next generation sequencing;Pharmaceutical Preparations;Postdoctoral Fellow;precision medicine;precision oncology;Preparation;Production;programs;Proteomics;Publications;Records;Recurrence;Research;Research Design;Research Personnel;Research Support;Resolution;Resource Sharing;response;Robotics;S10 grant;Science;screening;sequencing platform;Services;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Split-Pool Ligation Transcriptome sequencing;statistics;Strategic Planning;Students;Technology;therapy resistant;Training and Education;transcriptome;transcriptome sequencing;transcriptomics;translational impact;Treatment outcome;tumor;United States National Institutes of Health

PROJECT_TITLE: Cancer Genomics Shared Resource


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The development of versatile and practical methods for organic synthesis is critical to the discovery and manufacture of molecular structures relevant to understanding biological mechanisms and treating human disease. In this proposal, we will pursue the design of new reactions and elucidation of fundamental reactivity principles in the areas of Ni-catalyzed cross coupling and phosphoranyl radical catalysis. In so doing, this research will provide new tools for the selective and efficient preparation of biologically relevant small molecules from simple and abundant starting materials.

PI_NAMEs: DOYLE, ABIGAIL GUTMANN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Academia;Address;Adopted;Alcohols;Architecture;Area;Biological;biological preparation;Carbon;Catalysis;catalyst;chemical reaction;Chemical Structure;Chemicals;Chemistry;community engagement;Complex;Coupling;design;Development;drug candidate;Drug Industry;Electrons;Goals;graduate student;human disease;Hydrogen Bonding;improved;invention;Laboratories;Life;Ligands;manufacture;Medicine;Methods;molecular manufacturing;Molecular Structure;Nickel;novel;Organic Synthesis;oxidation;Oxidation-Reduction;Phosphines;Postdoctoral Fellow;Process;programs;Property;Reaction;Research;Research Assistant;Research Personnel;Route;Site;small molecule;Structure;System;tool;Training;Transition Elements;undergraduate research;Visible Radiation;Work

PROJECT_TITLE: New Directions in Nickel and Photoredox Catalysis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


PROJECT_TERMS: American Association of Cancer Research;Award;Baptist Church;Biomedical Research;Cancer Biology;Cancer Cell Growth;Cancer cell line;Cancer Center Support Grant;Cancer Model;cancer therapy;Cancerous;Cell Culture Techniques;cell growth;Cell Line;Cells;cellular engineering;cellular transduction;Cessation of life;Charge;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Comprehensive Cancer Center;Computers and Advanced Instrumentation;Consultations;cost effective;CRISPR/Cas technology;Culture Media;Custom;Dependovirus;design;Development;DNA;Doctor of Philosophy;Dyes;Engineering;Equipment;established cell line;exosome;experience;experimental study;expression vector;fluorescence imaging;Formulation;Foundations;Frequencies;functional genomics;Funding;Gene Expression;gene therapy;gene-editing approach;Generations;Genes;genetic manipulation;Grant;Guide RNA;Hemoglobin;high throughput screening;Hypoxia;Image;imaging approach;In Vitro;in vivo;in vivo fluorescence;in vivo imaging;instrument;instrumentation;interest;Investments;Label;Laboratories;Lentivirus;Libraries;Liquid substance;luminescence;Malignant Neoplasms;Measurement;member;microvesicles;mid-career faculty;Modernization;Molecular;Molecular Biology;Monitor;Mutation;Mycoplasma;Names;nanoparticle;Nanotechnology;Nitrogen;Non-Viral Vector;Nucleotides;Patients;Peer Review;photoacoustic imaging;Physiological Processes;Plasmid Cloning Vector;Plasmids;Play;Procedures;Production;programs;Publications;Reagent;Reporter;Reporter Genes;repository;Research Personnel;Resolvase;Resource Sharing;Resources;Retroviridae;Ribonucleoproteins;Rodent;Sampling;Scientist;Services;Site;small hairpin RNA;small molecule;System;Techniques;Technology;Testing;Time;tissue culture;tissue/cell culture;Training;translational goal;treatment response;tumor growth;Universities;Validation;Vendor;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: Cell Engineering Shared Resource


ADMINISTERING_IC: DC

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative / Public Health Relevance A shortage of Otolaryngology surgeon-scientists emerging from training has been identified. Surgeon-scientists play a key role in bridging basic and clinical research, in an effort to develop new disease treatments. This proposal aims to provide Otolaryngology trainees with immersive research training as part of an academic career development pathway.

PI_NAMEs: FRANCIS, HOWARD W;GOLDSTEIN, BRADLEY J (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;Achievement;Address;Applied Research;Area;Basic Science;Biomedical Research;Biometry;career;Career Choice;career development;Clinical;Clinical Research;clinical training;Clinical Treatment;Communication;Dedications;design;Development;Devices;Disease;driving force;Eligibility Determination;experience;Faculty;faculty mentor;Failure;Feedback;Fellowship;Funding;Generations;Goals;Head and Neck Surgery;Infrastructure;interest;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Minority;National Institute on Deafness and Other Communication Disorders;next generation;novel therapeutics;Operative Surgical Procedures;Otolaryngologist;Otolaryngology;Participant;Pathway interactions;Patients;Phase;Physicians;Physicians' Offices;Play;population health;Positioning Attribute;Preparation;Production;programs;public health relevance;Qualifying;recruit;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;role model;Science;Scientist;skill acquisition;Structure;student training;Students;Study Section;success;Surgeon;Technology;Training;Training Programs;Translations;trend;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Otolaryngology Surgeon- Scientist career Path (OSSP) program


PROJECT_TERMS: Acceleration;Advanced Development;Affect;Agreement;anti-cancer research;Applications Grants;Award;Baptist Church;Basic Science;Biological;Biological Sciences;Biology;Biophysics;Biotechnology;Cancer Center Support Grant;cancer genetics;cancer prevention;cancer therapy;Catalysis;Clinic;Clinical Research;cofactor;Collection;Complex;Comprehensive Cancer Center;Computational Biology;Conceptions;Consultations;Crystallization;Crystallography;Data;Data Collection;design;Development;DNA;DNA Repair;DNA Repair Gene;DNA-Protein Interaction;Docking;Doctor of Philosophy;Drug Interactions;Enzymes;Equipment;experience;experimental study;Extramural Activities;Foundations;Functional disorder;Funding;Goals;graduate student;Grant;human disease;Industry;inhibitor;Intellectual Property;Investigation;Ligands;Malignant Neoplasms;member;method development;Modeling;Molecular;Mutation;National Institute of Allergy and Infectious Disease;National Institute of Drug Abuse;National Institute of General Medical Sciences;neuro-oncology;North Carolina;novel;novel strategies;novel therapeutics;Oxidation-Reduction;Pharmaceutical Preparations;Post-Translational Protein Processing;Postdoctoral Fellow;Production;programs;Protein Dynamics;protein expression;protein function;protein structure;Proteins;Publications;Recombinant Proteins;Research;Research Personnel;Resource Sharing;Resources;RNA;Roentgen Rays;Scientist;Screening for cancer;Secure;Services;Signal Transduction;simulation;small molecule;Specificity;structural biology;Structure;student participation;Therapeutic;Training;Training Programs;Translations;tumor metabolism;United States National Institutes of Health;Work;X-Ray Crystallography

PROJECT_TITLE: Crystallography and Computational Biology Shared Resource


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Genomic organization in the 3-dimensional nuclear space emerges as a new epigenetic regulator of transcriptional specificity that affects various developmental processes. The olfactory system provides an ideal system for deciphering in vivo the structural principles and regulatory significance of nuclear architecture, since it utilizes this regulation of the nuclear architecture for the monogenic and monoallelic expression of olfactory receptor genes. Thus, our experiments are likely to reveal generally applicable principles for the role of mRNA in the formation of activating genomic compartments during neuronal differentiation and to uncover perturbations in genomic compartmentalization that are linked to neurodevelopmental disorders.

PI_NAMEs: LOMVARDAS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Affect;Alleles;Architecture;Binding;Binding Proteins;Biochemical;Cell Differentiation process;Chromatin;Chromosome Structures;Code;Complex;Data;Development;Developmental Process;Enhancers;Environment;Epigenetic Process;Experimental Genetics;experimental study;Feedback;Gene Cluster;Gene Expression;Gene Family;gene translocation;Generations;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Transcription;genomic locus;Genomics;Greek;Human;In Situ;in vivo;insight;interdisciplinary approach;Island;Light;Link;Mediating;Messenger RNA;Molecular;Mus;nerve stem cell;Neurodevelopmental Disorder;Neuronal Differentiation;novel;Nuclear;Nuclear Proteins;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Other Genetics;Phase;Phase Transition;Process;Production;programs;promoter;Property;Proteins;receptor expression;Receptor Gene;recruit;Regulation;Reporting;Repression;RNA;RNA-Binding Proteins;Role;Signal Transduction;Specificity;Structure;System;transcription factor;Transcriptional Regulation;Untranslated RNA;Yeasts

PROJECT_TITLE: Olfactory receptor mRNAs as lncRNAs that regulate genomic interactions

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Acceleration;Address;Antibodies;Award;Bacteria;Baptist Church;Basic Science;Cancer Biology;Cancer Center Support Grant;cell analyzer;Cell Cycle;Cell Line;Cell Separation;Cells;Charge;Comprehensive Cancer Center;Computer software;cost effective;Cytometry;Data;Data Analyses;design;Detection;Development;Discrimination;DNA;Doctor of Philosophy;Experimental Designs;Flow Cytometry;Flow Cytometry Shared Resource;Fostering;Funding;Goals;Grant;high dimensionality;Human;Immunotherapy;Individual;insight;instrument;instrumentation;Lasers;light scattering;Machine Learning;member;Methodology;Multivariate Analysis;NCI Center for Cancer Research;operation;Peer Review;peer support;phenotypic biomarker;Population;programs;Property;protocol development;Protocols documentation;Publications;Reporting;Research;Research Personnel;Research Support;Resource Sharing;Resources;Rodent;Seasons;Services;single cell analysis;Sorting;success;Technology;Titrations;Training;Transfection;Translational Research;tumor immunology;Viral Vector;Virus;Wood material

PROJECT_TITLE: Flow Cytometry Shared Resource


PROJECT_TERMS: Area;Award;Baptist Church;Basic Science;Biochemical;Biocompatible Materials;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biology;Biometry;Biotechnology;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer risk;career development;Cells;Chemistry;Chromatography;Clinical;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;Computer software;Consultations;Couples;Cysteine;Data Analyses;data repository;data sharing;Detection;Development;Doctor of Philosophy;Education;Educational Activities;Ensure;Equipment;exosome;experience;Fee-for-Service Plans;Financial Support;Fluorescence;Foundations;Funding;Genomics Shared Resource;Glutathione;Goals;Grant;gut microbiota;High Pressure Liquid Chromatography;Hour;Human Resources;improved;Industry;Institution;instrument;instrumentation;Investments;Kentucky;Laboratories;Libraries;lipidomics;Lipids;MALDI-TOF Mass Spectrometry;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measures;medical schools;Medicine;member;Metabolic;metabolomics;Methodology;Methods;multiple omics;Names;Natural Compound;Natural Products;North Carolina;Nucleic Acids;oncology service;operation;Oxidation-Reduction;oxidized lipid;Patients;Peptides;Pharmaceutical Preparations;Plasma;precision medicine;precision oncology;Preparation;Prevention;programs;Proteins;Proteomics;Publications;Quality Control;Quality of life;Reporting;Research;Research Support;Resource Sharing;Resources;Risk Assessment;Salivary;Sampling;Schedule;Series;Services;small molecule;Specimen;stable isotope;Standardization;System;Technology;Testing;Tobacco;tool;Training;Training and Education;Tumor Pathology;Tumor Tissue;United States National Aeronautics and Space Administration;United States National Institutes of Health;Universities;Update;Urine

PROJECT_TITLE: Proteomics and Metabolomics Shared Resource


NIH_SPENDING_CATS: Diabetes

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Dysfunction to insulin secreting cells causes diabetes. Insulin-secreting cells show extensive electrical communication to regulate insulin secretion, and this communication is disrupted during diabetes. Understanding how this electrical communication is disrupted in diabetes will identify targets for retaining normal electrical communication and insulin secretion, thus providing potential drug targets for diabetes prevention.

PI_NAMEs: BENNINGER, RICHARD KP (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Actins;Address;Affect;Animal Model;Beta Cell;Binding;blood glucose regulation;C-terminal;Cell Death;Cell membrane;Cell Physiology;cell type;Cells;Communication;Compensation;Coupling;Cyclic AMP;cytokine;Cytoskeleton;Diabetes Mellitus;Diabetes prevention;diabetic;diabetogenic;Disease;Disease Progression;Drug Targeting;Endocrine;Functional disorder;Funding;gap junction channel;Gap Junctions;Genetic Transcription;Glucose;Goals;Hormones;Human;imaging approach;improved;Inflammatory;Insulin;insulin regulation;Insulin Resistance;insulin secretion;intercellular communication;islet;Islets of Langerhans;Knowledge;live cell imaging;Measures;Mediating;Microtubules;Molecular;mouse model;Nonesterified Fatty Acids;NPAS4 gene;nuclear factors of activated T-cells;Pathway interactions;Pattern;Permeability;Persons;Phosphorylation Inhibition;Physiological;Play;Prediabetes syndrome;preservation;prevent;programs;Proteins;RAS Superfamily Proteins;Regulation;Research;response;Role;Signal Transduction;Testing;therapeutic target;Time;trafficking;Work

PROJECT_TITLE: Gap Junction Communication and Islet Function in Diabetes

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


PROJECT_TERMS: Address;Adherence;anti-cancer research;Applications Grants;Area;Award;Baptist Church;Benchmarking;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer health equity;Cancer Patient;cancer prevention;care delivery;Caregivers;Catchment Area;Clinical;clinical practice;Clinical Research;Clinical Trials Design;clinically relevant;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Consumption;Data;Data Analyses;Data Collection;data registry;design;Development;disparity reduction;Doctor of Philosophy;eHealth;Evaluation;Evidence based practice;experience;Extramural Activities;Faculty;Funding;Goals;Grant;Health;health care delivery;Health Personnel;Health Policy;health related quality of life;Health system;Hour;implementation facilitators;improved;improved outcome;Infrastructure;Institution;interest;Intervention;intervention delivery;Investigation;Investigator-Initiated Research;Leadership;Learning;Malignant Neoplasms;Manuscripts;Measurement;Medical;member;Mentors;Methodology;Methods;National Center for Complementary and Integrative Health;Nature;NCI Center for Cancer Research;novel;Outcome;Outcome Measure;Outcomes Research;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Peer Review;Policies;Population;population health;professor;programs;Protocols documentation;Psychometrics;Publications;Qualitative Research;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Resource Sharing;Resources;Sampling Studies;Science Policy;Services;Shapes;Social Sciences;Symptoms;Time;tool;Training and Education;treatment strategy;usability

PROJECT_TITLE: Qualitative and Patient-Reported Outcomes Shared Resource


PROJECT_TERMS: 3-Dimensional;Animal Experiments;animal tissue;Animals;anti-cancer research;Applications Grants;Asian;Baptist Church;Biology;Black race;Blood;Body Fluids;Brain;Breast;Cancer Center;Cancer Center Support Grant;cancer genomics;Catchment Area;cell type;Cells;Certification;Childhood;Clinical;Clinical Data;clinical development;Clinical Pathology;Clinical Protocols;Clinical Research;Collaborations;Collection;community engagement;Community Outreach;comparative;Comparative Pathology;Comprehensive Cancer Center;Consent;Cooperative Human Tissue Network;cost;cost effective;Custom;Data;data warehouse;Dedications;Development;Dissociation;Doctor of Philosophy;Drug or chemical Tissue Distribution;Evaluation;Faculty;Female;Formalin;Freezing;Fresh Tissue;Funding;Genomics Shared Resource;Goals;Hispanic;Histologic;Human;Human Pathology;human tissue;Informatics;Institution;Institutional Review Boards;instrumentation;Investigation;Laboratories;Leadership;Leukocytes;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;member;Metabolism;Modeling;multiple omics;Mus;neoplastic;neoplastic cell;nonhuman primate;nonhuman tissue;Normal tissue morphology;Not Hispanic or Latino;novel therapeutics;online resource;operation;Organoids;Paraffin Embedding;Participant;Pathologic;Pathologist;Pathology;Patients;Peer Review;personalized cancer therapy;Phase I Clinical Trials;Pilot Projects;Plasma;Population;Preparation;Process;Production;prospective;Prostate;Proteomics;Qualifying;Quality Control;recruit;Reporting;repository;Research;research and development;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Rodent;sample collection;Sampling;Serum;service utilization;Services;single-cell RNA sequencing;Source;Specimen;Stains;System;Tissue Banks;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Sample;Tissues;tool;Training;translational cancer research;Translational Research;tumor;tumor microenvironment;Tumor Pathology;Tumor Tissue;Vendor;Vial device;Work

PROJECT_TITLE: Tumor Tissue and Pathology Shared Resource


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Early life exposures such as a diverse microbiome are inversely related to the risk of developing allergic diseases and asthma. We will use multi-omics techniques to test whether traditional agrarian microbial exposures and colonization promote immune development and airway epithelial cell functions in young children to reduce the risks of respiratory illnesses, allergies and asthma. The results of these studies of traditional agrarian exposures and health benefits will provide critical information that can be used to improve the health of all children.

PI_NAMEs: GERN, JAMES E. (contact);SEROOGY, CHRISTINE MARIE

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 2 year old;Adult;Affect;airway epithelium;airway hyperresponsiveness;Allergic;allergic airway inflammation;Allergic Disease;Amish;Animal Model;Animals;Anti-Bacterial Agents;Anti-viral Response;Asthma;Atopic Dermatitis;Bacteria;Birth;Blood Cells;burden of illness;CD8B1 gene;cell age;Cell Physiology;Cells;Child;Clinical;cohort;Cohort Studies;Communities;cytokine;Data;design;Development;Disease;Dust;early life exposure;Environment;Epithelial Cells;Epithelium;Exposure to;Extrinsic asthma;Family;Farm;Farming environment;Feces;gastrointestinal;Gastrointestinal tract structure;Gene Expression Profile;Genes;Goals;Health;Health Benefit;Health Promotion;healthcare burden;Home;Hypersensitivity;Immune;Immune response;Immunity;improved;in vitro Model;Individual;infancy;Infant;Inflammation;Inflammatory;Inflammatory Response;Life;Lipids;Measures;Mediating;Mediator;microbial;microbial signature;microbiome;microbiota;monocyte;multiple omics;Nasopharynx;neutrophil;Nose;Outcome;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;Patients;Pattern;Phenotype;Plasma;prenatal;Prevalence;prevent;Preventive treatment;Production;programs;Proteins;Regulatory T-Lymphocyte;Research;respiratory;respiratory health;Respiratory syncytial virus;respiratory virus;response;rhinoconjunctivitis;Rhinovirus;Risk;Role;Sampling;Signal Pathway;Societies;Source;suburb;Techniques;Testing;TNF gene;Virus;Wheezing;Wisconsin

PROJECT_TITLE: Interactions Between the Microbiome, Immunity and Respiratory Health in Traditional Agrarian and Suburban children


NIH_SPENDING_CATS: Asthma;Lung;Microbiome;Pediatric

PHR: PROJECT NARRATIVE Not Applicable to Research Projects under this RFA.

PI_NAMEs: GERN, JAMES E. (contact)

PROJECT_TERMS: airway epithelium;Allergic Disease;Asthma;bacterial genetics;Bacteriology;Chicago;Child;Childhood;Collaborations;Communication;Development;Ensure;Epithelial Cells;Extrinsic asthma;Farm;Goals;Hypersensitivity;Immune;Immunity;Immunology;Leadership;Manuscripts;member;microbial;microbiome;National Institute of Allergy and Infectious Disease;organizational structure;Preparation;Principal Investigator;programs;Research;Research Personnel;Research Project Grants;Resources;respiratory;respiratory health;Review Committee;San Francisco;Site;suburb;Vertebral column;virology;Wisconsin

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: SEROOGY, CHRISTINE MARIE (contact)

PROJECT_TERMS: 2 year old;5 year old;Address;airway epithelium;Allergic;Allergic Disease;Amish;Anti-viral Response;arm;Asthma;Atopic Dermatitis;Automobile Driving;Birth;Blood;case control;Cells;Child;Childhood;Chronic Disease;cohort;Cohort Studies;Communicable Diseases;Communities;Competence;Cross-Sectional Studies;Custom;cytokine;Dairying;Data;Development;Disease;disorder risk;DNA Methylation;early childhood;early life exposure;Enrollment;Environment;Environmental Exposure;Epigenetic Process;Epithelial Cells;Epithelium;experience;Exposure to;Family;Farm;Farming environment;Frequencies;Gene Expression;Gene Expression Profile;General Population;Genes;Goals;gut microbiota;Health Benefit;Hypersensitivity;Immune;Immune system;Immunity;immunoregulation;improved;Incidence;infancy;Infant;infection rate;Inflammatory;Inflammatory Response Pathway;insight;Intervention;Life;Life Style;Livestock;Longitudinal Studies;Mediating;metabolomics;Methylation;methylation pattern;microbial;microbial colonization;microbial community;microbiome;Modification;monocyte;Mucous Membrane;Nasal Epithelium;nasal microbiota;Nose;novel;Outcome;Participant;Pathway interactions;Phase;Phenotype;Physiology;Population;postnatal;Pregnant Women;prenatal exposure;Prevalence;Production;protective effect;Proteomics;Publishing;Regulatory T-Lymphocyte;Research Project Grants;respiratory;Respiratory Disease;respiratory health;response;Risk;Risk Reduction;Role;Rural;School-Age Population;Severities;Shapes;Specificity;Structure of mucous membrane of nose;suburb;Technology;Time;Tissues;Training;transcriptomics;two-arm study;Viral;Viral Respiratory Tract Infection;Wisconsin;Work

PROJECT_TITLE: Project 1: Immune development and respiratory outcomes in children from diverse Wisconsin communities


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Telehealth

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Our proposed project will test the implementation of the NHLBI-funded NEW Soul program and how the program can lead to significant improvements in dietary and weight outcomes. The goal of this study is to develop a ready to adopt intervention in African American owned vegan restaurants. This study will test an entirely remotely delivered behavioral intervention that has the ability to be scaled up so that reach of this treatment approach is broad.

PI_NAMEs: TURNER-MCGRIEVY, GABRIELLE MICHELLE (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Action Research;active control;Address;Adopted;Adoption;Affect;African American;African American population;Area;Behavior Therapy;Body Weight;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Communities;community advisory board;Community Health Aides;community partners;Consolidated Framework for Implementation Research;Consultations;cooking;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;cost outcomes;design;Development;Diabetes Mellitus;Diet;dietary;Eating;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;effectiveness/implementation trial;efficacy study;evidence base;Fatty acid glycerol esters;Focus Groups;Food;Funding;Goals;Health Food;Healthy Eating;Hybrids;Hypertension;implementation intervention;implementation outcomes;implementation strategy;implementation study;improved;indexing;Individual;informant;Infrastructure;innovation;Intervention;intervention cost;intervention program;Intervention Studies;Interview;Knowledge;LDL Cholesterol Lipoproteins;Letters;National Heart, Lung, and Blood Institute;Nutritional;Obesity;online delivery;online intervention;Outcome;Overweight;Participant;Phase;Plants;Prevention Research;Process;Proctor framework;programs;Quality-Adjusted Life Years;Randomized;remote delivery;Research Methodology;Restaurants;retention rate;Risk;scale up;skills;staff intervention;Structure;Surveys;Testing;Training;Translations;Universities;Vegan Diet;videoconference;voucher;Weight;Work

PROJECT_TITLE: Expanding the reach of the Nutritious Eating with Soul (NEW Soul) program: A Type 2 hybrid effectiveness-implementation trial

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Infectious Diseases;Lung;Microbiome;Nutrition;Pediatric;Prevention;Rehabilitation;Social Determinants of Health

PI_NAMEs: ONG, IRENE M (contact)

PROJECT_TERMS: 2 year old;Activities of Daily Living;Affect;airway epithelium;Allergic;Allergic Disease;Amish;Anti-Allergic Agents;Anti-Bacterial Agents;Asthma;Bacteria;Bifidobacterium;Biological Assay;Birth;Blood;candidate selection;Cells;Child;Clinical;cohort;Cohort Studies;Color;Computer Analysis;Consumption;Corynebacterium;Dairying;Data;Data Analyses;data integration;Data Set;Development;Disease;Distal;DNA Methylation;Environment;Epithelial Cells;Epithelium;evidence base;experimental study;Exposure to;Family;Farm;Farming environment;Feces;Food;gastrointestinal epithelium;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;gut colonization;gut microbiome;gut microbiota;Health Benefit;Hemophilus;Hypersensitivity;Immune;Immune response;Immune system;Immune System Diseases;Immunity;immunoregulation;Infant;Infection;Inflammation;Learning;Life;Life Style;Link;longitudinal analysis;Lung;Measures;Metabolic;metabolome;metabolomics;Metagenomics;metatranscriptome;metatranscriptomics;Microbe;microbial;microbial colonization;Microbial Genetics;microbiome;microbiota;microorganism;Modernization;Moraxella;Mucous Membrane;Multiomic Data;multiple omics;nasal microbiome;Newborn Infant;next generation;Nose;novel;Nutrient;Organ;Outcome;pathogen;pathogenic bacteria;pathogenic virus;Pathogenicity;Pattern;peripheral blood;Plasma;postnatal;prenatal;prenatal exposure;Prevalence;Prevention;Primary Prevention;Probiotics;Property;Prophylactic treatment;Proteome;racial minority;Research Personnel;Research Project Grants;Resistance;respiratory;respiratory colonization;respiratory health;respiratory microbiome;respiratory microbiota;Respiratory Tract Infections;response;Risk;Sampling;School-Age Population;secondary metabolite;Severities;Shapes;Solid;suburb;Systems Analysis;Testing;Thinness;transcriptome;treatment strategy;Viral;Viral Respiratory Tract Infection;Wheezing;Wisconsin

PROJECT_TITLE: Project 2: Relating the functional capacities of the GI and nasal microbiomes to immune development in children from traditional and modern exposures


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative In humans and in monkeys neurological findings, functional magnetic resonance imaging (fMRI), and electrophysiology have all converged to show that the object recognition part of the visual pathway is divided up into domains specialized for processing specific object categories, such as faces, text, places, and body parts; these domains underlie complex social behavior, and astonishing skills like fluent reading. The project goal is to explore how early experience interacts with innate programs to generate the remarkable selectivity of neurons in these domains. Early life experiences clearly can have long lasting consequences, and treating these consequences requires an understanding of how some kinds of experience, or the deprivation thereof, can permanently change how the brain processes visual information.

PI_NAMEs: LIVINGSTONE, MARGARET S (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 1 year old;3D Print;Adolescent;Adult;Affect;Anatomy;Animal Testing;Animals;Area;Auditory;Behavior;behavior test;Behavioral;Birth;Body part;Brain;Categories;Cells;Chronic;Complex;cortex mapping;density;deprivation;Development;early experience;Electrodes;Electrophysiology (science);experience;extrastriate visual cortex;Eye;Face;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Goggles;Hand;Helmet;Human;Infant;inferotemporal cortex;Inherited;insight;lens;Life;Life Experience;Macaca;Maps;Measures;Modality;Monitor;Monkeys;Motor;multi-electrode arrays;Neonatal;Neurological observations;Neurons;object recognition;Play;postnatal;prevent;programs;Property;Reading;Recovery;Research;response;Role;Scanning;Sensory;sensory system;Site;skills;Social Behavior;somatosensory;Stimulus;System;Techniques;Temporal Lobe;Testing;Text;Time;Vision;Visual;Visual Cortex;Visual Fields;visual information;visual map;Visual Pathways;visual processing;Visual System;Work

PROJECT_TITLE: Development of domains in inferotemporal cortex

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE  While monoclonal antibodies inhibiting immune checkpoints (ICI) are able to restore anti-tumor immunity and have dramatically changed the therapeutic options for many cancer patients, up 60% of patients will experience immune-related adverse events (irAE) depending on the tumor type and ICI. The importance of predicting and managing ICI-related adverse events has already been identified as a critical gap in knowledge and clinical practice. Targeting a common molecular node of integration for the innate immune system in irAE, we have discovered a novel positron emission tomography (PET) radiopharmaceutical that we propose to drive into a first-in-human safety/dosimetry Phase 0/1 trial for whole-body imaging and quantitative surveillance of ICI- mediated irAE by PET.

PI_NAMEs: PIWNICA-WORMS, DAVID  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Adverse event;Binding;Biochemical;Biological;Biology;Biotechnology;Cancer Patient;Cells;checkpoint inhibition;Chemistry;Clinical;clinical imaging;clinical practice;cohort;Data;diagnostic value;Disease;dosimetry;experience;first-in-human;Generations;Goals;Hot Spot;Human;human imaging;Image;imaging study;Immune;immune checkpoint;immune-related adverse events;Immunologic Monitoring;Immunologic Surveillance;Immunological Diagnosis;in vivo;Infiltration;Inflammatory;Injections;Innate Immune System;Institutional Review Boards;interest;Intervention;Investigation;Iron;Knowledge;Laboratories;liver inflammation;Macrophage;male;Mediating;Molecular;Monoclonal Antibodies;Mus;Myelogenous;NADPH Oxidase;Naphthols;Natural Immunity;Nature;neutrophil;Nitrogen;novel;Organ;Oxidants;Oxidation-Reduction;Participant;Pathway interactions;patient population;Patients;Peroxidases;Phase;Phase 0/1 Trial;Positron-Emission Tomography;precision medicine;primary endpoint;Process;Production;prospective;Proteins;Radiopharmaceuticals;radiotracer;Reaction;Reactive Oxygen Species;Reagent;Recording of previous events;Reporter;Reporting;Safety;safety study;Series;Serum;side effect;Signal Transduction;Signaling Molecule;small molecule;Superoxides;Therapeutic;Time;Tissues;Tracer;tumor;Tumor Immunity;University of Texas M D Anderson Cancer Center;Validation;whole body imaging;women patients;X-Ray Computed Tomography

PROJECT_TITLE: First-in-Human Imaging of Innate Immunity Activation with a Redox-Tuned PET Reporter


ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The MYC oncogene is the most common cancer gene involved in human cancer and is overexpressed in over half of all cancers. However, there has been a paucity of small molecule MYC inhibitors amenable to in vivo efficacy studies. We have developed new small molecule inhibitors of MYC with in vivo efficacy and tolerability that we will use to probe MYC function in vitro and vivo.

PI_NAMEs: ABDULKADIR, SARKI A. (contact);CHAKRAVARTI, DEBABRATA

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: 3-Dimensional;activating transcription factor;Affect;Animal Model;antitumor effect;Architecture;ATAC-seq;Binding;Biochemical;biological adaptation to stress;Biology;c-myc Genes;Cancer Model;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Cessation of life;Chemicals;Chromatin;Chromatin Structure;Combined Modality Therapy;Complex;Computer Assisted;Consensus;Coupled;cytokine;Dependence;DNA;DNA Binding;Drug Kinetics;efficacy study;Epigenetic Process;Event;Family;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Genome;genome-wide;genomic locus;Genomics;glycogen synthase kinase 3 beta;Helix-Turn-Helix Motifs;Human;in silico;In Vitro;in vivo;inhibitor;knock-down;Knowledge;leukemia;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;member;Modeling;multicatalytic endopeptidase complex;MYC Family Protein;MYC gene;neoplastic cell;novel;novel strategies;Oncogenes;Oncogenic;Oncoproteins;Output;overexpression;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Play;programs;Proliferating;Proteasome Inhibitor;Proteins;Publishing;recruit;Recurrence;response;Role;screening;Series;Site;small molecule;small molecule inhibitor;Stress;Testing;Therapeutic;Threonine;Toxicology;transcription factor;Transcriptional Activation;transcriptome sequencing;tumor;tumor microenvironment;tumorigenesis;Tumorigenicity;Ubiquitin;Up-Regulation;Work

PROJECT_TITLE: Small molecule probes of MYC stability and function intumorigenesis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BJORK, JAMES M (contact);NEALE, MICHAEL CHURTON

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Bioinformatics;Biological Assay;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Registries;Research;research and development;Research Personnel;Research Project Grants;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;Social Functioning;Social isolation;Specific qualifier value;Standardization;substance use;Symptoms;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;Universities;Virginia;Youth

PROJECT_TITLE: 20/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT VCU


NIH_SPENDING_CATS: Asthma;Clinical Research;Infectious Diseases;Lung;Microbiome;Pediatric;Social Determinants of Health

PROJECT_TERMS: airway epithelium;Allergic Disease;Amish;anti-microbial peptide;Anti-viral Response;Antibacterial Response;Antibiotics;antimicrobial;Asthma;Atopic Dermatitis;Bacteria;Bacteriology;Cell Differentiation process;cell growth;Cell Physiology;Cells;Characteristics;Child;Childhood;Childhood Asthma;Cohort Studies;Collaborations;commensal bacteria;commensal microbes;Communities;Corynebacterium;Dairying;Data;design;Development;Disease;Environment;Environmental Exposure;Epithelial Cells;Epithelium;European;Exposure to;Family;Farm;Funding;Gene Cluster;Genes;Genetic;Genetic Transcription;Goals;Growth;gut microbiota;Haemophilus influenzae;Health;Health Benefit;Hypersensitivity;Immune;Immune Tolerance;Immunity;Immunology;improved;in vitro Model;Infant;Infection;Inflammatory;Lead;Life;Medical Microbiology;Medicine;metagenome;Microbe;microbial;microbiome;Moraxella catarrhalis;Mucous body substance;Nose;novel;novel therapeutic intervention;Outcome;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;Phenotype;postnatal period;Predisposition;prenatal;Preschool Child;Production;programs;Research Project Grants;respiratory;respiratory health;respiratory microbiome;respiratory pathogen;Respiratory Signs and Symptoms;response;Rhinovirus;Risk;Risk Reduction;screening;Source;Structure;suburb;Testing;transcriptomics;Urban Health;Viral;Virus Diseases;Virus Replication;Wheezing;Wisconsin

PROJECT_TITLE: Project 3: Interactions between microbial metabolites, airway pathogens and airway epithelial cell function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE  Drosophila is a model system used to map neural circuits and study cell firing during innate behaviors, such as feeding; to understand how neuromodulation regulates behavior or encodes memories, we need tools to examine multiple neuromodulators throughout a circuit. Here, we will develop new multiplexed tools to study neuromodulator interactions in Drosophila during sugar feeding. These tools are critical to understanding how genetics, behavior, or disease alter neuromodulator release, and will facilitate using Drosophila as a model organism for studying neuromodulation in neurological diseases, such as schizophrenia, compulsive eating, and addiction.

PI_NAMEs: VENTON, B. JILL (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Action Potentials;addiction;Adult;analytical tool;Anterior;Autoreceptors;Behavior;Behavior Control;Behavioral;Binge Eating;Biological Models;Brain;Cells;Chemicals;combat;Complex;conditioning;Data;Data Analyses;Desire for food;Detection;Disease;Dopamine;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;experimental study;feeding;Feeding behaviors;fly;Frequencies;Future;Genetic;Genetic study;glutamatergic signaling;Glutamates;Goals;Grant;in vivo;insight;Instinct;Knowledge;Larva;Lobe;Maps;Measurement;Measures;Medial;Memory;memory encoding;Mental disorders;Methods;model organism;Monitor;Mushroom Bodies;Mutation;nanoelectrodes;Nervous System Disorder;neural circuit;neurochemistry;Neuromodulator;neuronal circuitry;Neurons;Neuropil;neuroregulation;Neurosciences;neurotransmission;Neurotransmitters;Octopamine;Odors;Olfactory Learning;optogenetics;Outcome;Output;Pattern;Periodicity;Regulation;Research;response;Rewards;Role;Scanning;Schizophrenia;selective expression;sensor;sensory system;Serotonin;Signal Transduction;sugar;Synapses;temporal measurement;Testing;Time;tool;Work

PROJECT_TITLE: Real-Time Measurements of Neurotransmission in Drosphilia melanogaster

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The increasing prevalence of HIV drug resistance is a threat to HIV treatment and prevention. An HIV drug resistance database that curates, annotates, and synthesizes the primary data from many studies will be an invaluable research resource to the many researchers performing drug resistance surveillance, managing persons with HIV, and discovering new antiviral drugs. The proposed project will advance research to combat the threat that HIV drug resistance poses to containing the HIV pandemic.

PI_NAMEs: SHAFER, ROBERT WILLIAM (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;Anti-viral Agents;Anti-viral Therapy;antiretroviral therapy;Biological;Capsid;Clinical;Clinical Data;Clinical Management;Clinical Trials;Cohort Studies;combat;Computer software;Conduct Clinical Trials;COVID-19 treatment;Data;Data Collection;Data Set;data sharing;database query;Databases;design;Development;drug development;Drug resistance;drug resistant virus;Ensure;Epidemiologist;Epidemiology;experience;Failure;fighting;Fostering;Foundations;Funding;Genbank;Genotype;Geographic Locations;Goals;Grant;high risk;HIV;HIV drug resistance;HIV therapy;improved;In Vitro;Individual;Integrase;Knowledge;knowledge base;Laboratories;Laboratory Research;Literature;Logic;Meta-Analysis;Metadata;Modernization;molecular sequence database;Molecular Target;Monitor;Mutation;novel;novel strategies;open source;Outcome;pandemic disease;pathogenic virus;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Play;population based;Positioning Attribute;predicting response;Predisposition;Prevalence;Prevention;programs;public database;Public Health;public repository;Publishing;R24;Recording of previous events;recruit;Regimen;Research;Research Personnel;Resistance;resistance mutation;Resources;response;RNA-Directed DNA Polymerase;Role;Scientist;Sequence Analysis;Sorting;success;systematic review;targeted treatment;Testing;Therapy Clinical Trials;transmission process;Update;Virus;Work

PROJECT_TITLE: HIV Drug Resistance Database


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

ORG_CITY: IRVINE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Only 4% of the human proteome (20,171 human proteins) has been liganded by chemical probes. The majority of the proteome is undruggable by small molecules. Cyclic peptides are considered as promising molecules to address the undruggable targets, but its larger molecular mass and more complex secondary structures result in unpredictable and almost always low cell permeation, significantly limiting their utility as drug candidates. This proposal will develop analytical assays and tools for the detection and screening of cell-penetrating cyclic peptides as tool compounds for platform development. Screening results will be used to build machine learning models of permeation and inform its applications in next-generation diagnostics and therapeutics.

PI_NAMEs: HU, JUAN  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: 3-Dimensional;A549;academic preparation;Academic Training;Address;Alkynes;Amino Acids;Area;assay development;Azides;Binding;Biological Assay;Biology;Carboxylic Acids;career;career development;Career Mobility;Cell Line;Cell Membrane Permeability;Cells;Cellular Assay;Chemicals;Classification;Clinic;Collaborations;combinatorial;Communities;Complex;computational chemistry;conformer;Copper;Coupled;Cyclic Peptides;cycloaddition;Cysteine;Data;Data Set;Descriptor;design;Detection;Development;Diagnostic;dimension reduction;DNA;drug candidate;Drug Kinetics;Encapsulated;Engineering;Environment;Exhibits;Funding;Future;Generations;Goals;Growth;Hand;Hela Cells;high throughput screening;high throughput technology;Human;Hydrogen Bonding;Image;In Vitro;Institution;job market;Label;Libraries;Ligands;Lipids;Liposomes;Machine Learning;machine learning model;Measurement;member;Membrane;Microfluidics;miniaturize;Modality;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular mass;next generation;novel;novel diagnostics;novel therapeutics;Penetration;Peptides;Periodicity;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phospholipids;Positioning Attribute;pre-clinical;Proline;propargylamine;Property;protein protein interaction;Proteins;Proteome;Publishing;Radial;Reaction;Research;Research Personnel;S phase;screening;Screening Result;skills;small molecule;small molecule libraries;Solid;Solvents;Sorting;Structure;Structure-Activity Relationship;Surface;Techniques;Technology;technology development;Testing;Thalidomide;Therapeutic;tool;Training;Vesicle;Visualization;Water

PROJECT_TITLE: Pharmacokinetics-Based DNA-Encoded Library Screening


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The goal of this work is to better understand the impaired phospholipid metabolism in the glaucomatous trabecular meshwork (TM) tissue. Proposal will evaluate the enzymatic activities in the phospholipid metabolism pathways. Successful completion of this research will yield new insight into the phospholipid metabolic impairment in the TM and their possible potential modulation in the treatment of glaucoma.

PI_NAMEs: BHATTACHARYA, SANJOY K (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;analytical method;Anterior;anterior chamber;Aqueous Humor;Atomic Force Microscopy;Biological Assay;biophysical properties;Cadaver;Carrier Proteins;Cell membrane;Cells;cellular transduction;comparison control;Data;Development;Diagnosis;Disease;Elasticity;enzyme activity;Enzyme-Linked Immunosorbent Assay;Enzymes;Etiology;Evaluation;Exclusion;experience;eye chamber;Filopodia;Functional disorder;Gender;Generations;Glaucoma;Goals;Histocytochemistry;Human;Immunosorbents;Impairment;improved;In Vitro;Injury;innovation;insight;Integral Membrane Protein;Intervention;Kinetics;Knowledge;Lateral;Lecithin;Length;lipid metabolism;Lipids;Location;Mammals;mass spectrometric imaging;Mediating;Membrane;Membrane Lipids;Metabolic;Metabolic Pathway;Metabolism;Methods;microscopic imaging;Modulus;mouse model;Mus;novel;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Phosphatidylethanolamine;Phosphatidylserines;phosphoethanolamine;Phospholipid Metabolism;Phospholipid Transfer Proteins;Phospholipids;Physiologic Intraocular Pressure;pressure;prevent;Prevention;Primary Open Angle Glaucoma;Proteins;Research;Resistance;Sampling;Signal Transduction;Stretching;Techniques;Testing;Therapeutic;Tissues;Trabecular meshwork structure;Western Blotting;Work

PROJECT_TITLE: Impaired phospholipid metabolism in glaucoma

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Disease-modifying treatments are urgently needed to slow the progression of Alzheimer’s Disease (AD), the most common neurodegenerative disorder that leads to dementia and dependency world-wide. Microglia and blood monocytes that enter the brain, can both positively and negatively impact AD progression and our exciting preliminary data suggests that Kv1.3 channels expressed by brain immune cells represent therapeutic targets to mitigate detrimental neuroinflammation in AD. In this proposal, we will perform in-vivo mechanistic and therapeutic studies in pre-clinical models of AD with the overall goal of laying the pre-clinical foundation for translation of Kv1.3 blockers to humans.

PI_NAMEs: RANGARAJU, SRIKANT  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Acute;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid beta-Protein;analog;Anti-Inflammatory Agents;Apoptosis;Astrocytosis;Autoimmune Diseases;Award;Behavioral;behavioral outcome;Biological Assay;Biological Markers;Biological Response Modifiers;Biology;biomarker discovery;Bone Marrow;Brain;brain cell;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Chimera organism;conditioned fear;Coupled;Data;Dementia;Dependence;Disease;Disease Progression;efficacy testing;experimental study;Flow Cytometry;Foundations;Future;Gene Deletion;genetic approach;glial activation;Goals;Health Expenditures;Hematopoietic;Human;Immune;immune function;Immune signaling;Immunophenotyping;immunoregulation;Immunotherapeutic agent;improved;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;intervention effect;irradiation;Kv1.3 potassium channel;Lead;LoxP-flanked allele;Macrophage;MAP Kinase Gene;Marrow;Mass Spectrum Analysis;Mediating;Microglia;Modeling;monocyte;Mononuclear;mouse model;multidisciplinary;Mus;Nerve Degeneration;neuro-immunomodulatory therapies;neurobehavioral;Neurodegenerative Disorders;neuroimmunology;Neuroimmunomodulation;neuroinflammation;neuronal survival;neuropathology;new therapeutic target;novel;object recognition;Outcome;p38 Mitogen Activated Protein Kinase;Pathologic;Pathology;Pathway interactions;Peripheral;Phagocytes;pharmacologic;Pharmacology;Phase;Phenotype;pre-clinical;Pre-Clinical Model;preclinical efficacy;protein biomarkers;PTPRC gene;radioresistant;ratiometric;reconstitution;release of sequestered calcium ion into cytoplasm;Research Personnel;response;Role;Safety;selective expression;Shapes;Signal Pathway;small molecule;Stimulus;Synapses;tau aggregation;tau Proteins;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutic target;transcriptomics;Translating;translation to humans;Translations;Treatment Efficacy;Wood material

PROJECT_TITLE: Targeting Kv1.3 potassium channels for neuro-immunomodulation in Alzheimer's Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Microbiome;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Acute Lung Injury is a devastating and prevalent condition with poorly understood links to the gut microbiome. I propose to study how host control of a key gut bacterium changes pulmonary metabolite exposure from the gut microbiome and downstream inflammation during Acute Lung Injury. This project will lay the foundation for future studies defining how gut bacteria change lung function in alignment with NHLBI strategic vision 1.CQ.07.

PI_NAMEs: UPADHYAY, VAIBHAV  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Ablation;Acute Lung Injury;Acute Respiratory Distress Syndrome;Advisory Committees;Alveolar;Area;Bacteria;bacterial metabolism;beta-Hydroxybutyrate;Bifidobacterium;Biology;career;career development;Cell Physiology;Cells;Cessation of life;Clinical;Communication;Coupled;COVID-19;Data;Data Analyses;Disease;experimental study;Foundations;Future;gastrointestinal epithelium;Genes;Germ-Free;Gnotobiotic;Grant;Growth;gut bacteria;gut microbiome;Health;Human;IL17 gene;immune function;Immune system;Impairment;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Injury;innovation;intestinal epithelium;ketogentic;Ketone Bodies;Ketones;Knowledge;Laboratories;Learning;Link;Liquid substance;Lung;Lung Diseases;lung injury;Measurement;Measures;Mediating;Mentors;Microbiology;microbiome;microbiome research;microorganism;Modeling;Molecular;Mus;National Heart, Lung, and Blood Institute;Organism;Pathology;Pathway interactions;Patients;Phenotype;Physicians;Physiological;Play;Pneumococcal Pneumonia;Pneumonia;Positioning Attribute;programs;pulmonary function;Research;Research Infrastructure;Resources;response;Role;Scientist;Serum;Severities;skills;small molecule;Strategic vision;Structure of parenchyma of lung;T-Lymphocyte;Technology;Testing;tool;Training;training opportunity;Work

PROJECT_TITLE: Impact of gut bacterial metabolites on lung function and disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

PHR: Project Narrative Aging with HIV may be associated with a greater impairment in physical function and worse fatigue, contributing to an impaired healthspan; few therapies are effective in slowing physical function decline or improving fatigue in people with or without HIV. Here we propose to test two exercise regimens of varying interval and intensity (high-intensity interval training vs continuous moderate-intensity exercise) on changes in physical function, fatigue, and mitochondrial bioenergetics. Furthermore, we will explore the impact of a biobehavioral coaching intervention vs control on adherence to physical activity following the supervised exercise intervention.

PI_NAMEs: ERLANDSON, KRISTINE MACE (contact);WEBEL, ALLISON R

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;Address;Adherence;Aerobic;Aerobic Exercise;Age;Age related comorbidities;aged;Aging;analytical method;antiretroviral therapy;arm;Attenuated;Behavior;Behavioral;biobehavior;Bioenergetics;Body fat;Caring;Chronic Disease;Clinical;Clinical Trials;Colorado;common symptom;comorbidity;Coronary Arteriosclerosis;daily functioning;Data;demographics;design;Development;Diabetes Mellitus;early experience;Electron Transport;Epidemic;Exercise;exercise adherence;exercise intensity;exercise intervention;exercise program;exercise regimen;experience;Fatigue;Geriatrics;Goals;Habits;Health;healthspan;Healthy People 2020;Heart Rate;High Prevalence;HIV;Impairment;improved;innovation;Interval training;Intervention;Interview;Knowledge;Life;Life Expectancy;lifestyle factors;Maintenance;Maximum Heart Rate;Methods;Mitochondria;Moderate Exercise;Morbidity - disease rate;mortality;muscle form;Nonpharmacologic Therapy;older adult;Older Population;Outcome;Participant;Patients;Perception;Performance;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;Population;preservation;Quality of life;Randomized;Recommendation;reduce symptoms;Reporting;Resistance;resistance exercise;Resources;Respiration;response;Sample Size;Self Direction;Site;Skeletal Muscle;Specific qualifier value;Symptom Burden;tailored text messaging;Testing;Time;Training;trial comparing;United States National Institutes of Health;Universities;Vulnerable Populations;Walking;Woman

PROJECT_TITLE: The High-Intensity Exercise to Attenuate Limitations and Train Habits (HEALTH) in Older Adults with HIV


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Oxytocin is a maternal hormone important for childbirth, parent-child bonding, and social cognition. However, it is unclear how, when, or where oxytocin acts in the brain to enable successful maternal care, or if oxytocin is involved in social transmission of parental behaviors from experienced care-takers to new care-takers. The experiments to be performed in this proposal provide essential data on the action of oxytocin in the brain, required for improvement of therapeutic strategies for treatment of maternal neglect or other conditions relating to incorrect processing and behavioral responses to social stimuli.

PI_NAMEs: FROEMKE, ROBERT CROOKS (contact)

PROGRAM_OFFICER_NAME: MANN KOEPKE, KATHY M

PROJECT_TERMS: Acceleration;Afferent Neurons;Anatomy;Animals;Anxiety;Area;Auditory;Auditory area;Behavior;Behavioral;behavioral response;behavioral study;biobehavior;Biological;Brain;Caregivers;Caring;Cells;Child;Child Abuse and Neglect;Child Care;Child Development;child neglect;Child Rearing;Childbirth;Clinical Research;Crying;Cues;Data;Distress;Educational Intervention;Educational process of instructing;Electrophysiology (science);Ensure;experience;experimental study;Female;Head;Helping Behavior;Home;Hormones;Human;Hypothalamic structure;improved;in vivo;Individual;Infant;Lactation;Learning;Mammals;Maps;Maternal Behavior;Maternal Physiology;Mental Health;Modality;Monitor;Mothers;Motivation;Motor;movie;Mus;neglect;neonate;neural;neural circuit;neurobehavioral;Neuroendocrinology;neuromechanism;Neuronal Plasticity;Neurons;Neurosciences;Neurosecretory Systems;offspring;optogenetics;Oxytocin;Pair Bond;paraventricular nucleus;Parents;parvocellular;Patients;peptide hormone;physical conditioning;Population;Postpartum Depression;Primates;Process;pup;recruit;response;Retrieval;sensor;Sensory;sensory input;Signal Transduction;Slice;social;Social Behavior;social cognition;Social Interaction;somatosensory;statistics;Stimulus;success;suckling;superior colliculus Corpora quadrigemina;supraoptic nucleus;System;Testing;Therapeutic;Therapeutic Agents;Training;Training Programs;transmission process;treatment strategy;Ultrasonics;Visual;vocalization

PROJECT_TITLE: Neural circuitry of oxytocin signaling for alloparenting behavior

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Dissemination and Implementation Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative Uganda is currently scaling up proven malaria control interventions, but these efforts are not sufficient to adequately reduce the high malaria burden in the country, and resurgence after discontinuation of control measures has been experienced. These observations highlight an urgent need for continued research that informs optimal malaria interventions, and thus a necessity for the training of Ugandans to lead this research. Improved in-country expertise in epidemiology, translational research, and implementation science will be critical to assist the Ministry of Health in establishing effective policies for the better control and eventual elimination of malaria in Uganda.

PI_NAMEs: DORSEY, MATTHEW G;KAMYA, MOSES ROBERT (contact);NANKABIRWA, JOANITER IMMACULATE

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Artemisinins;Bioinformatics;Collaborations;Complex;COVID-19 pandemic;Degree program;design;Doctor of Philosophy;Educational Status;Ensure;Epidemiology;Europe;experience;Faculty;Fellowship;Genomics;Goals;graduate student;Growth;Health;implementation science;improved;Incidence;Insecticide Resistance;Institution;institutional capacity;Intervention;Lead;Leadership;Malaria;Master of Science;Mentors;Needs Assessment;Outcome;Output;Policies;post-doctoral training;Postdoctoral Fellow;programs;Publications;Research;Research Personnel;Research Project Grants;Research Training;Resistance;Scientist;skill acquisition;Supervision;Training;Training Programs;Training Support;Translational Research;Uganda;Universities

PROJECT_TITLE: Training in Malaria Epidemiology, Translational Research, and Implementation Science to Strengthen Malaria Policy and Control in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Complementary and Integrative Health;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Physiological and contextual mechanisms of Force-Based Manipulations (FBM) lack understanding resulting in poor clinical transferability. Our team (ForceNet) will establish a large network of interdisciplinary force-based researchers and professionals to overcome FBM force-related metrics, mechanistic, and contextual barriers via the creation and dissemination of new FBM knowledge.

PI_NAMEs: COOK, CHAD ;REED, WILLIAM RAY (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Acceleration;Address;Afferent Pathways;Alberta province;Area;Artificial Intelligence;Behavioral;Behavioral Research;Big Data;Biological;Biomechanics;career;Cellular biology;cellular imaging;Charge;Clinical;clinical care;clinical efficacy;clinical practice;Collaborations;Communities;contextual factors;Delaware;Delphi Study;design;Development;Discipline;dissemination strategy;Educational workshop;Elements;Event;Extramural Activities;Funding;Future;Goals;Grant;Growth;Human;Image;Immunology;Institution;Integrative Medicine;interdisciplinary collaboration;Interdisciplinary Study;International;Intervention;Journals;Knowledge;Leadership;Literature;Manipulative Therapies;Massage;Measurement;mechanical force;mechanotransduction;Mediating;meetings;member;Mentors;Methodology;Methods;minimally invasive;Molecular Biology;Musculoskeletal Pain;neural;neural circuit;neuroimaging;neuromechanism;Neurons;Neurosciences;novel;Outcome;Pathologic;Physiological;Physiology;Pilot Projects;Positioning Attribute;pre-clinical;Probability;Process;Psychology;psychosocial;Psychosocial Factor;Publications;Published Comment;Publishing;receptor;Recording of previous events;Research;Research Personnel;Research Priority;Resources;response;Role;Scientist;secondary analysis;Sensory;Series;skills;social;social media;special interest group;Spinal;Spinal Ganglia;Spinal nerve root structure;synergism;systematic review;Techniques;Technology;Therapeutic;Therapeutic Uses;Time;Tissues;tool;Touch sensation;Treatment/Psychosocial Effects;United States National Institutes of Health;Universities;virtual;web site;webinar;Work

PROJECT_TITLE: Force-Based Manipulations Research Network