ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Cone beam CT (CBCT) is becoming an indispensable imaging modality for minimally invasive image-guided interventions. High quality CBCT imaging plays a pivotal role in guaranteeing the success of diagnostic and treatment procedures. In this project, a new CBCT imaging platform that integrates both a photon counting detector and a flat panel detector to provide much improved soft-tissue contrast detectability and quantitative spectral CT image guidance will be developed to enable more accurate diagnoses and image guidance for treatment planning and treatment delivery.

PI_NAMEs: CHEN, GUANG-HONG  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Affect;Algorithms;Animals;Bite;Brain imaging;Cadaver;Calibration;Canis familiaris;Clinical;clinical application;Compton radiation;cone-beam computed tomography;contrast enhanced;cost;Data;data acquisition;Dedications;design;Detection;detector;Development;Diagnosis;Diagnostic;Diagnostic Imaging;digital;Disease;disease diagnosis;Dose;Evaluation;Family suidae;Feasibility Studies;Future;Head;Hemorrhage;high risk;Human;human subject;Image;image guided;image guided intervention;image guided radiation therapy;imaging capabilities;imaging detector;imaging modality;imaging platform;imaging system;improved;in vivo;innovation;Intervention;Iodine;Lesion;Magnetic Resonance Imaging;Maps;Measures;Medical;minimally invasive;Monitor;Morphologic artifacts;next generation;novel;Operative Surgical Procedures;Patients;Performance;photon-counting detector;Physicians;Play;preservation;Procedures;prototype;quantitative imaging;quantum;Radiation;research clinical testing;Resolution;Roentgen Rays;Role;Rotation;Scheme;Signal Transduction;soft tissue;spectrograph;success;System;Technology;Three-Dimensional Imaging;treatment planning;Tube;Visualization;white matter;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Next Generation Cone Beam CT with Improved Contrast Resolution and Added Spectral Imaging Functionality

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Glycosylation is an abundant and complex co-translational modification of proteins that impacts protein folding, maturation, stability, subcellular localization, and enzymatic activity. While critical roles of N-linked glycosylation are beginning to emerge in the brain, its involvement in Alzheimer's disease (AD) remains largely unknown. We provided preliminary data in support of N-linked glycan alterations as a driver of AD disease pathology, the goal of this proposal is to define the cellular and extracellular events underlying altered N-link glycan metabolism in AD.

PI_NAMEs: ANGEL, PEGGI M;BENDALL, SEAN CURTIS;DRAKE, RICHARD R.;SUN, RAMON C. (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Age;Algorithms;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Anabolism;analysis pipeline;Architecture;Astrocytes;Biological;Brain;Brain region;carbohydrate metabolism;Carbohydrates;Cell Physiology;Cells;cellular imaging;Central Nervous System;Central Nervous System Diseases;cerebrovascular pathology;Clinical;Clinical Course of Disease;Co-Translational Protein Processing;Code;Cognition;cognitive performance;cohort;Complex;Data;Dementia;design;Development;Diagnosis;Dimensions;Disease;Disease Progression;Education;effective therapy;Endothelium;Event;extracellular;Extracellular Matrix;Glucosamine;glucose metabolism;Glycogen;glycosylation;Goals;Heterogeneity;Hippocampus;Human;human disease;Image;imaging approach;imaging platform;Impaired cognition;insight;Knowledge;life span;Link;Maps;mass spectrometric imaging;Measures;Memory;Metabolic;Metabolism;Metadata;Methodology;Microglia;Molecular;mouse model;multimodality;Multiplexed Ion Beam Imaging;Multivariate Analysis;nanoscale;Neighborhoods;Neurobiology;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neuropathology;Oral;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Physiology;Play;Polysaccharides;Prefrontal Cortex;Process;protein folding;Proteins;Proteomics;Regional Anatomy;Research Personnel;Role;Sampling;sex;single cell technology;Slice;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Staging;Study models;Therapeutic;Time;Tissue imaging;Tissues

PROJECT_TITLE: Deciphering the Glycan Code in Human Alzheimer's Disease Brain


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SHREVEPORT

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Human Papillomaviruses infect keratinocytes in the skin and mucosa and induce epithelial tumors. In order to cause disease virus has to deliver its genome to the nucleus of the basal cells of this stratified epithelia. Herein, we propose to fill gaps in our understanding of late events of viral trafficking and establishment of infection, which in turn allows identification of novel targets for prevention.

PI_NAMEs: YUROCHKO, ANDREW D;ZWOLINSKA, KATARZYNA  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Accidents;Anaphase;Basal Ganglia;Binding;Body Composition;candidate identification;Cell Culture Techniques;Cell Nucleus;Cells;Chromosomes;Cytoplasmic Organelle;Data;Deposition;Dissociation;Dynein ATPase;Electron Microscopy;Endosomes;Enzymes;Epithelium;Event;follow-up;Genetic Transcription;Genome;Homeostasis;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Image;Immune;Impairment;Infection;inhibitor;JAK1 gene;keratinocyte;Kinesin;Kinetics;knock-down;Knock-out;Knowledge;L2 viral capsid protein;Life Cycle Stages;Link;Lipase;live cell imaging;Maintenance;Mediating;Membrane;Metaphase;Microscopy;Microtubule Proteins;Microtubule-Organizing Center;Microtubules;Minor;Mitosis;Mitotic;Mitotic Chromosome;Mitotic spindle;Modeling;Motor;Mucous Membrane;mutant;Natural Immunity;novel;Nuclear;Nuclear Envelope;nucleocytoplasmic transport;Pathway interactions;pharmacologic;Phase;Phospholipase;Phospholipase C;Play;prevent;Prevention;Prophase;Protein Isoforms;Proteins;Quality Control;recruit;Reporting;Research;Role;sensor;Signal Transduction;Skin;Small Interfering RNA;small molecule inhibitor;Stains;Stratified Epithelium;Techniques;Testing;Thinking;Time;trafficking;trans-Golgi Network;Transcriptional Regulation;tumor;Vesicle;vesicle transport;Viral;Viral Genome;Virion;Virus Diseases

PROJECT_TITLE: Human papillomavirus entry: late trafficking and establishment of infection


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: Chronic liver injury leads to scarring which impairs liver function and leads to liver failure; however there are no therapeutic options to limit or reverse scaring formation. A subset of liver cells produce scar tissue, and this process causes cellular stress which cells must overcome to survive and promote fibrosis. The goal of our project is to understand how liver cells accommodate stress to produce excess scar tissue, and inhibit these processes to limit or reverse liver fibrosis.

PI_NAMEs: MAIERS, JESSICA L (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: antifibrotic treatment;Apoptosis;arm;Autophagocytosis;Binding;Cell Separation;Cell Survival;Cells;Cellular Stress;Chemicals;chronic liver injury;Cicatrix;Cirrhosis;Data;Deposition;Development;end stage liver disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Excision;Extracellular Space;Failure;fibrogenesis;Fibrosis;GADD45A gene;gene induction;Genes;Genetic Transcription;Genomics;global health;Goals;Golgi Apparatus;Health;Hepatic Fibrogenesis;Hepatic Stellate Cell;Hepatocyte;Impairment;In Vitro;in vivo;Injury;insight;Intervention;Liver;Liver Cirrhosis;Liver Failure;Liver Fibrosis;liver function;liver injury;lysosomal proteins;Lysosomes;Mediating;misfolded protein;Mus;new therapeutic target;non-alcoholic fatty liver disease;Pathway interactions;Patients;Phosphotransferases;Post-Translational Regulation;posttranscriptional;Process;Procollagen;Production;protein degradation;protein folding;Protein Secretion;protein transport;Proteins;Proteome;Proteomics;proteostasis;receptor;Regulation;Research;response;Role;Secretory Cell;Signal Transduction;Stress;Testing;Therapeutic;therapeutically effective;Tissues;trafficking;transcriptome sequencing;Transforming Growth Factor beta;Universities;Validation

PROJECT_TITLE: Elucidating the Role and Regulation of Proteostasis in Hepatic Fibrogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Normal cellular proliferation requires an orderly progression through the cell cycle, but cancer cells proliferate inappropriately and without end causing morbidity and mortality. Since tumor cells proliferate inappropriately, precise inhibition of the cell cycle may lead to the death of tumor cells while normal cells may be spared. Herein we investigate CDK1 as a therapeutic target for cancer with broad utility in tumors and metastasis.

PI_NAMEs: GOGA, ANDREI  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Acute;Affect;Alleles;analog;Animal Model;Animals;Biochemical;Biological Assay;Biology;Bypass;Cancer Biology;cancer cell;cancer therapy;CDC2 gene;Cell Aging;Cell Cycle;Cell Cycle Inhibition;Cell Cycle Regulation;Cell Death;Cell division;Cell Fraction;Cell Physiology;Cell Proliferation;cell transformation;Cells;Cessation of life;chemical genetics;Chemicals;Chromosome Segregation;clinical translation;Clinical Trials;Compensation;Coupled;Cyclin B;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Development;Disseminated Malignant Neoplasm;DNA biosynthesis;DNA Damage;early phase clinical trial;Engineering;Epidermal Growth Factor Receptor;epigenetic regulation;Eukaryotic Cell;Event;genetic approach;Genetic Models;Growth;Homeostasis;Human;Immunotherapy;in vivo;in vivo evaluation;inhibitor;innovation;interest;kinase inhibitor;Lead;Life;M cell;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;Maps;Mitosis;Mitotic;model organism;Modeling;Mole the mammal;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Normal Cell;Normal tissue morphology;novel;Oncogenes;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Phase;Phosphotransferases;Play;Precision therapeutics;Primary Neoplasm;programs;Proliferating;Protein Biosynthesis;Protein Family;Protein Kinase;Proteins;Publishing;receptor;Regulation;Research;Research Personnel;response;Role;senescence;senolytics;Signal Pathway;Signal Transduction;small molecule inhibitor;synthetic lethal interaction;targeted cancer therapy;targeted treatment;Therapeutic;therapeutic target;Time;Toxic effect;Transgenic Mice;Transgenic Organisms;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Tissue

PROJECT_TITLE: Understanding CDK1 Function and Cancer Vulnerabilities

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is an important cause of death in adults with high mortality rate (80%) if rupture occurs. Chronic inflammation and vascular smooth muscle cell dysfunction have been well documented in AAA pathogenesis in both AAA patients and animal models. This study will provide compelling evidence and new findings that will lead to novel strategies for developing effective therapeutics to treat AAA.

PI_NAMEs: GUO, YANHONG  (contact);SCHWENDEMAN, ANNA

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acceleration;Adult;Aneurysm;Angiotensin II;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Aorta;Aortic Rupture;Arterial Fatty Streak;Atherosclerosis;beta Aminopropionitrile;Biological Availability;Cardiovascular Diseases;Cause of Death;Cells;Characteristics;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical Trials;Data;Death Rate;Development;Dilatation - action;Disease;Dissection;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Drug Targeting;effective therapy;Elastases;Encapsulated;Extracellular Matrix Degradation;Fatty Acids;Formulation;Functional disorder;Genetic study;Growth;Human;Human Genetics;Image;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Lesion;Libraries;lipid metabolism;Lung Diseases;Macrophage;Mediating;Medical;Michigan;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Muscle function;Muscular Atrophy;Names;nanoparticle;nanotherapeutic;new therapeutic target;nitroalkene;Nitrogen Dioxide;novel;novel strategies;novel therapeutics;Nuclear;Oleic Acids;Operative Surgical Procedures;p65;particle;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase II Clinical Trials;Phospholipids;Play;preservation;prevent;Property;protective effect;protective pathway;Proteolysis;repaired;Reporting;Risk Reduction;Role;Rupture;Ruptured Aneurysm;side effect;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Stimulus;Therapeutic;Therapeutic Agents;therapeutically effective;TLR4 gene;Toxic effect;vascular inflammation;Vascular Smooth Muscle;Work

PROJECT_TITLE: Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysm

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Lung;Mental Health;Pediatric;Prevention;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research will fill a gap in the science by examining respiratory sinus arrhythmia (RSA), a marker of emotion regulation, as a predictor of adolescent substance use and sexual risk. Such markers are needed for reliably identifying vulnerable early adolescents for targeted prevention interventions to address Healthy People 2020 objectives related to adolescent health, including pregnancy prevention (FP-8.1), sexually transmitted diseases (HIV-2, STD-2), alcohol use (SA-14.4), and marijuana use (SA-13.2).

PI_NAMEs: HADLEY, WENDY S;HOUCK, CHRISTOPHER D. (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Adolescent Risk Behavior;adolescent substance use;Age;Alcohol consumption;analog;Behavioral;biomarker identification;Breathing;Classification;Collection;computerized;Computers;Data;early adolescence;Early identification;early onset substance use;emotion regulation;Emotional;Emotions;Environment;Event;Exhibits;Exposure to;follow-up;Frequencies;Health;Healthy People 2020;heart rate variability;HIV-2;Hormones;improved;indexing;innovation;insight;Intervention;Laboratories;Literature;marijuana use;Measurement;Measures;Mental Health;Modeling;novel;Outcome;Parasympathetic Nervous System;parental monitoring;Parents;Participant;Patient Self-Report;Pattern;peer;peer influence;Pilot Projects;Play;pregnancy prevention;Prevention;preventive intervention;Process;prospective;Puberty;Race;Recording of previous events;Recovery;Regulation;Reporting;Research;Resources;respiratory;respiratory challenge;respiratory examination;response;Rest;Risk;Risk Behaviors;Risk Marker;risk prediction;Risk Taking;Role;Sampling;Science;sex;Sex Behavior;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Sinus Arrhythmia;substance use;success;Symptoms;Testing;Time;tool;virtual reality;virtual reality environment;vulnerable adolescent;Youth

PROJECT_TITLE: Respiratory Sinus Arrhythmia as a Predictor of Substance Use among Early Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: Project Narrative  Cystathionine β synthase (CBS) regulation is critical to maintaining low levels of intracellular homocysteine. In this study I will examine how mutations in a linker of human CBS alter the enzyme’s catalytic activity, AdoMet induced activation, and redox mediated inhibition. I will also elucidate how these changes translate into a cellular context. These studies will provide insight into the mechanism by which the transsulfuration pathway is controlled.

PI_NAMEs: ROMAN, JOSEPH V. (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Active Sites;Address;Affect;Allosteric Regulation;Anabolism;Binding;Biochemical;Biochemical Pathway;Biogenesis;Biological Assay;Body System;C-terminal;Cardiovascular system;Catalytic Domain;cofactor;Colon Adenocarcinoma;Communication;conformational conversion;Couples;Crystallization;Cystathionine;Cystathionine beta-Synthase;Cysteine;Cysteine Desulfhydrase;Data;Dimerization;Disease;Distal;Environment;Enzymes;Equilibrium;Exhibits;flexibility;Functional disorder;Heme;heme a;Hemeproteins;Homocysteine;Homocystinuria;HT29 Cells;Human;Hydrogen Sulfide;In Vitro;Inherited;insight;interest;Kinetics;Laboratories;lanthionine;Length;Mammalian Cell;Maps;Mediating;Missense Mutation;Molecular;Molecular Conformation;monomer;mutant;Mutation;N-terminal;Nervous System;Oxidation-Reduction;Pathogenicity;Pathway interactions;patient subsets;Patients;Physical condensation;potentiometric titration;Process;Proteins;Pyridoxal Phosphate;Reaction;Recombinants;Regulation;respiratory toxin;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serine;Site;Skeletal system;Spectrophotometry;Spectrum Analysis;stable cell line;Structure;Sulfur;tautomer;Testing;Translating;Variant;Visual System;Water;X-Ray Crystallography

PROJECT_TITLE: Allosteric regulation of human cystathionine beta-synthase


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The research team proposes to identify patterns of brain activity that increase risk for depression and psychosocial protective factors that can reduce this risk, which could be targeted in interventions for adolescents exposed to adversity to prevent the development of depression. Importantly, the research team will also measure allostatic load, an index of wear-and-tear on the body resulting from stress that predicts a range of physical and mental health problems, to identify protective factors that reduce risk for depression without raising allostatic load. This project is relevant to NIMH’s mission because it characterizes developmental processes that give rise to mental illness and identifies protective factors to serve as novel intervention targets.

PI_NAMEs: ROBINS, RICHARD W (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 10 year old;19 year old;Address;Adolescence;Adolescent;Adult;African American;Age;allostatic load;alpha-amylase;Anterior;biological adaptation to stress;biological sex;Blood;Blood Pressure;Brain;California;Cardiovascular Diseases;Chronic;cingulate cortex;coping;cost;Data;Data Collection;depressive symptoms;Development;Developmental Process;Diabetes Mellitus;Dryness;Economics;ethnic discrimination;ethnic identity;ethnic minority;ethnic minority population;Exhibits;experience;Exposure to;Face;Family;Functional Magnetic Resonance Imaging;Future;Goals;Health;high risk;Hydrocortisone;Impaired cognition;indexing;Individual;informant;Intervention;Knowledge;Latin American;Latino Population;Longitudinal Studies;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Mental Health;Mexican;Mission;Modeling;National Institute of Mental Health;neural;neuromechanism;novel;optimism;outcome prediction;Parent-Child Relations;Patient Self-Report;Pattern;perceived discrimination;Persons;physical conditioning;Population;predictive modeling;prevent;Process;promote resilience;prospective;protective factors;psychosocial;racial minority;Religiosity;Reporting;Research;resilience;Resistance;response;Rewards;Risk;Risk Factors;risk mitigation;Risk Reduction;Salivary;Sampling;self esteem;social exclusion;Specific qualifier value;Spottings;Stress;Testing;therapy development;United States;Ventral Striatum;Waist-Hip Ratio;young adult;Youth

PROJECT_TITLE: Risk and protective factors associated with the development of depression and allostatic load in young adults of Mexican origin.

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dietary Supplements;Eye Disease and Disorders of Vision;Nutrition;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE STRA6 is the receptor for retinol bound to its specific carrier in the bloodstream retinol binding protein, and it mediates cellular uptake of this essential nutrient. Understanding at the molecular level the relationship between the structure and the function of mammalian STRA6 is of high relevance to human health, as it may point at novel targets for therapeutic approaches in treatment of developmentally-related pathologies and diseases of the visual system. Indeed, mutations in the STRA6 gene have been associated with severe developmental malformations that are hallmarks of the Matthew-Wood syndrome, which among other phenotypes includes ocular defects ranging from mild microphthalmia to anophthalmia.

PI_NAMEs: KHELASHVILI, GEORGE ;MANCIA, FILIPPO  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;Adopted;Affect;All-Trans-Retinol;Anophthalmos;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;Biophysics;Blindness;Blood Circulation;Calcium;Calmodulin;Cell membrane;Cells;Cellular Retinol Binding Protein;Cholesterol;Complex;Cryoelectron Microscopy;Data;Data Analyses;Defect;density;design;Development;dietary;Diffuse;Diffusion;Disease;Dissociation;Environment;Event;Exhibits;experimental study;Eye;Fasting;Free Energy;Genes;Genetic Transcription;Health;Homeostasis;Human;Hydrophobicity;Information Theory;insight;Intake;Kinetics;Knockout Mice;Lateral;Ligands;Link;Lipids;Liver;machine learning method;malformation;Mammals;Maps;Mediating;Membrane;Metabolism;Methods;Microphthalmos;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;mutant;Mutation;Names;nanodisk;new therapeutic target;Nuclear Receptors;Nutrient;Organ;particle;Pathologic;Pathology;Peripheral;Phenotype;Physiological;Play;Positioning Attribute;Process;protein complex;RBP4 gene;receptor;reconstitution;Resolution;Rest;Retinal Pigments;Retinaldehyde;Retinoids;retinol binding protein receptor;Retinol Binding Proteins;Retinol Metabolism Pathway;Roentgen Rays;Role;Sampling;Sheep;simulation;Site;Statistical Mechanics;structural biology;Structure;Syndrome;System;Testing;therapy development;Thermodynamics;Tissues;Tretinoin;uptake;Vision;visual cycle;Visual System;Vitamin A;Vitamins;Wood material;Work;Zebrafish

PROJECT_TITLE: Structural basis of receptor-mediated cellular vitamin A uptake


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative It is difficult to predict recovery after severe traumatic brain injury (TBI). This prospective study will examine brain wave signals in response to listening to music and spoken words shortly after TBI in the intensive care unit. The results of this study will help clinicians know if their patients have chance of recovery after severe injury when discussing recovery and prognosis with family members.

PI_NAMEs: ALKHACHROUM, AYHAM  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Acute Brain Injuries;Age;auditory stimulus;Awareness;Biological Markers;Biometry;Brain;Brain Injuries;Caring;Cerebrum;Cessation of life;Clinical;clinical practice;Cognitive;cognitive function;cognitive neuroscience;Color;Coma;Conscious;Consciousness Disorders;Data;Data Science;Development;Electroencephalography;Electrophysiology (science);Family;Family member;follow-up;functional independence;Functional Magnetic Resonance Imaging;Goals;Hospitalization;Injury;Intensive Care;Intensive Care Units;Knowledge;Language;life-sustaining therapy;long term recovery;loved ones;Measures;Mentors;Modeling;Monitor;mortality;Motor;Music;neural;Neurologic;Neurologic Examination;neurophysiology;Neurosciences Research;novel;novel strategies;Outcome;Outcome Measure;Patients;Pattern;phrases;Predictive Value;preservation;Prognosis;prognostication;Prospective Studies;Radiologic Finding;Recovery;Recovery of Function;recruit;Research Personnel;research study;response;Scientist;severe injury;Signal Transduction;Societies;Speech;Stimulus;TBI Patients;Testing;Training;trauma centers;Traumatic Brain Injury;Traumatic Brain Injury recovery;Uncertainty;United States National Institutes of Health;Withdrawal

PROJECT_TITLE: MUSICA - MUsic and Speech Induced Cerebral Activation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Several proteins undergo misfolding, aggregation and become deposited in the brain of patients affected by Alzheimer's disease and related dementias. In this project we will produce and distribute alpha-synuclein polymorphic aggregates well-characterized for their size, biochemical, biophysical, structural and biological properties using various in vitro, cellular and animal models. These well-characterized and biologically relevant aggregates will be made freely available to the entire scientific community.

PI_NAMEs: SOTO, CLAUDIO  (contact)

PROJECT_TERMS: abeta accumulation;Adopted;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;amplification detection;Amyloid beta-Protein;Animal Model;Animals;Appearance;Biochemical;Biological;Biological Assay;biological systems;biophysical properties;Biophysics;Brain;Cell model;Cells;Characteristics;clinical phenotype;Communities;Cryoelectron Microscopy;Dementia;Dementia with Lewy Bodies;Deposition;Disease;Documentation;Ensure;Exhibits;Exposure to;Freezing;Goals;Guidelines;Human;In Vitro;in vivo;in vivo Model;Investigation;Laboratories;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Liquid substance;Methodology;misfolded protein;Modeling;Molecular Conformation;mouse model;Movement Disorders;neurodegenerative dementia;Neurofibrillary Tangles;Neurons;neurotoxic;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Patients;Polymorph;Prevalence;Process;Production;Property;protein aggregation;Proteins;Protocols documentation;reagent standardization;Reporter;Reproducibility;Research;Research Personnel;Resolution;Resources;response;Role;Sampling;Senile Plaques;Structure;synucleinopathy;tau aggregation;tau Proteins;Technology;United States National Institutes of Health;Variant

PROJECT_TITLE: Production and Distribution of well-characterized polymorphic variants of alpha-synuclein aggregates


NIH_SPENDING_CATS: Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Our expert team will develop novel approaches and gain biological insights into immune system control by IL33, innate lymphoid type 2 cells {ILC2s) and regulatory T cells (Tregs). Our findings have broad implications for the use of immune regulatory cell therapies in controlling adverse immune responses by focusing on translational applications for hematopoietic stem cell and solid organ transplantation and autoimmunity settings.

PI_NAMEs: BLAZAR, BRUCE R (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Acceleration;Acute Graft Versus Host Disease;Amphiregulin;Anti-Inflammatory Agents;Autoimmunity;Automobile Driving;Biological;Bone Marrow Transplantation;Cell Communication;Cell Cycle Regulation;Cell Proliferation;Cell secretion;Cell Therapy;cell type;Cells;chemotherapy;Chimerism;Clinical Trials;Coculture Techniques;congenic;cytokine;Data;Development;Disease;disorder control;dysbiosis;Environment;Epidermal Growth Factor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epithelial Cells;Epithelium;epithelium regeneration;Equilibrium;Funding;GATA3 gene;Gene Expression;Generations;Goals;Goblet Cells;graft vs host disease;Height;Hematopoietic stem cells;Homeostasis;Human;IL13RA1 gene;Immune;Immune response;Immune system;Immunologics;In Vitro;in vivo;Inflammatory;Infusion procedures;inhibitor;Injury;insight;Institution;Interleukin-13;Intestines;Knock-out;Knockout Mice;Literature;Lymphocyte;Lymphoid;Measures;Mediating;migration;Minnesota;Modeling;Monoclonal Antibodies;Mucins;Mus;Natural regeneration;Nature;neutralizing monoclonal antibodies;novel strategies;Organ Transplantation;Organoids;Paneth Cells;Patients;peripheral blood;Pharmaceutical Preparations;Phase;Population;prevent;Prevention;Process;Production;Prognosis;Progress Reports;Proliferating;Property;Protein Secretion;PTPRC gene;Refractory;Regimen;Regulatory T-Lymphocyte;repaired;Reporting;Research;Rodent;Role;Signal Transduction;Small Intestines;Solid;stem cells;Steroid Resistance;Steroids;Supporting Cell;T-Lymphocyte;Testing;Time;Tissues;trafficking;translational applications;translational impact;Transplant Recipients;Transplantation Conditioning;Universities;Whole-Body Irradiation;Wild Type Mouse

PROJECT_TITLE: In Vivo Prevention of Murine GVHD

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE: OVERALL The Michigan Program for Advancing Cultural Transformation (M-PACT) in the Biomedical and Health Sciences at the University of Michigan will hire 30 new tenure-track assistant professors into three interdisciplinary research clusters: Basic Biomedical Research; Clinical-Translational Research; and Social and Behavioral Research. M-PACT will harness existing infrastructure and resources, new institutional investments in training and development, and world-class research expertise and mentorship to nurture these early-career faculty for success as independent investigators and to build a sustainable scientific community that is diverse, equitable, inclusive and welcoming.

PI_NAMEs: JAGSI, RESHMA ;SELLERS, ROBERT M (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Administrator;Affect;Area;Awareness;Behavioral Research;Biomedical Research;Capital;career;career development;career networking;Climate;clinical translation;cohort;college;Communities;Complex;Creativeness;decanaldehyde;design;Development;early-career faculty;Educational Curriculum;Educational process of instructing;Educational Status;Engineering;Ensure;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;Evidence based practice;experience;Faculty;field study;Fostering;frontier;Funding;Gender;Goals;Grant;Health;health science research;Health Sciences;higher education;improved;Individual;Infrastructure;innovation;Institution;Institutionalization;Interdisciplinary Study;Intervention;Interview;Investments;Journals;Leadership;Literature;Medicine;Mentors;Mentorship;Methods;Michigan;Minority;minority communities;Minority Groups;Minority Status;Mission;Modeling;multiple data sources;Outcome;Outcome and Process Assessment;Policies;Positioning Attribute;Procedures;Process;Productivity;professor;Program Development;programs;Publishing;Race;Records;recruit;Research;Research Institute;Research Personnel;Resources;satisfaction;Scholarship;Schools;Science;Services;Sex Orientation;skills;social;Structure;success;Surveys;Teacher Professional Development;tenure track;Training;Translational Research;Underrepresented Minority;Underrepresented Populations;United States National Academy of Sciences;United States National Institutes of Health;Universities;University adminstration

PROJECT_TITLE: Michigan Program for Advancing Cultural Transformation (M-PACT) in Biomedical and Health Sciences


PI_NAMEs: SELLERS, ROBERT M (contact)

PROJECT_TERMS: Accountability;Address;Advisory Committees;Automobile Driving;career;cohort;college;Committee Members;Communication;Communities;Dedications;early-career faculty;Effectiveness;equity, diversity, and inclusion;Evaluation;Evidence based practice;experience;Faculty;Future Teacher;Goals;graduate student;health science research;Health Sciences;Human Resources;improved;Institution;Institutionalization;Knowledge;Leadership;Mentors;Michigan;Minority Graduate Student;Modeling;Office of Administrative Management;Outcome;Positioning Attribute;Postdoctoral Fellow;Procedures;Process;programs;Publications;Resource Sharing;Schools;social media;Structure;success;symposium;Teacher Professional Development;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-W]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Knowledge of the function of every human gene is necessary for determining the roles and relationships of genes and regulatory elements in various normal and disease-associated biological pathways and networks. In this project, we will leverage the state-of-the-art cellular engineering and single-cell capabilities of The Jackson Laboratory to comprehensively catalog the phenotypes of 250 null mutations in human induced pluripotent stem cells differentiated into extra-embryonic and neuroectodermal lineages. By focusing on these early embryonic lineages, we will gain important insight into multiple biological processes, including neurodevelopmental disorders and those impacting later life.

PI_NAMEs: ROBSON, PAUL  (contact);SKARNES, WILLIAM CARL

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Accountability;Address;Administrative Coordination;Affect;Alleles;Archives;Biological;Biological Assay;Biological Process;Catalogs;Cell Line;Cell Lineage;Cell Nucleus;cell type;Cells;cellular engineering;Clone Cells;Code;Communication;Communities;Data;data dissemination;data management;data resource;Development;Developmental Biology;Disease;Doctor of Philosophy;Embryo;Endocrine;Engineering;Ensure;epigenomics;Essential Genes;Excision;Exhibits;Exons;experience;Future;Gene Deletion;Generations;Genes;Genetic;Genetic Transcription;genome-wide;Genomic medicine;Giant Cells;Goals;Human;human disease;human induced pluripotent stem cells;Image;immunoregulation;induced pluripotent stem cell;Infrastructure;innovation;insight;Invaded;Knock-out;knockout gene;Knockout Mice;Knowledge;late life;Leadership;lipidomics;loss of function mutation;Mediating;meetings;metabolomics;Methods;Micronutrients;Molecular;molecular phenotype;Morphology;mutant;Mutation;Neurodevelopmental Disorder;Nucleic Acid Regulatory Sequences;null mutation;Nutrient;Pathway interactions;Phase;Phenotype;pleiotropism;pluripotent stem cell differentiation;premature;Primates;Process;Production;programs;Proteins;Protocols documentation;Regulatory Element;Research;research and development;Resolution;Resources;response;Role;Scheme;scientific organization;Scientist;Selection Criteria;sex;single cell analysis;skills;Specificity;stem cell biology;Structure;System;Technology;Terminator Codon;The Jackson Laboratory;Time;tool;transcription factor;transcriptomics;uptake;wasting;Work

PROJECT_TITLE: JAX MorPhiC Data Production Center


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHAVOUS, TABBYE MARIA (contact)

PROJECT_TERMS: access disparities;Address;Advocate;Applications Grants;Applied Skills;Area;Awareness;Behavioral Research;Biomedical Research;Budgets;career;career development;Climate;clinical translation;cohort;college;Communication;Communities;community building;Community of Practice;Complex;Creativeness;Cultural Backgrounds;design;Development;Dimensions;Discipline;Disparity;Diverse Workforce;early-career faculty;Educational workshop;Ensure;Environment;Equity;Event;evidence base;Evidence based practice;Faculty;faculty mentor;faculty support;Financial Support;Fostering;Foundational Skills;Funding;gender disparity;Goals;Grant;Health Sciences;improved;innovation;Institution;institutional capacity;Intervention;Knowledge;Laboratories;Leadership;Learning;member;Mentors;Michigan;Minority;minority scientist;Outcome;peer coaching;Positioning Attribute;Process;Productivity;programs;racial disparity;Readiness;Records;recruit;Research;Research Support;Resource Development;Resources;Schools;Science;Scientific Advances and Accomplishments;Scientist;Secure;senior faculty;Senior Scientist;skill acquisition;skills;social;Societies;Structure;Subgroup;success;support network;Talents;Teacher Professional Development;Time;Training;translational health science;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Vision;Writing

PROJECT_TITLE: Faculty-Development


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Muscular Dystrophy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: RELEVANCE Thousands of people in the United States suffer from Emery-Dreifuss and genetically-related forms of muscular dystrophy, inherited disorders for which there are no cures. This project will use novel mouse and cellular models to understand how mutations in different genes can cause Emery-Dreifuss muscular dystrophy and uncover cellular abnormalities that may be targeted by new therapies.

PI_NAMEs: WORMAN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adult;Affect;Alleles;Animals;autosome;Biological Models;Cardiac Myocytes;Cardiomyopathies;Cell model;Cells;Complement;Contracture;Cytoskeleton;Defect;Dilated Cardiomyopathy;Disease;Drug Targeting;Dystrophin;emerin;Emery-Dreifuss Muscular Dystrophy;env Gene Products;experimental study;Fiber;Gene Expression;Gene Mutation;Genes;Grant;Heart;Hereditary Disease;human induced pluripotent stem cells;induced pluripotent stem cell;injured;Injury;insight;Intermediate Filament Proteins;Joints;Lamin Type A;Lamins;Link;Modeling;mouse model;Mus;Muscle;Muscle Fibers;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Mutation;Myocardium;Myopathy;Natural regeneration;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Proteins;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathology;Patients;Persons;Phenotype;Physiological;polypeptide;Process;Proteins;Regenerative response;repaired;Research;Research Support;Role;Signal Transduction;Skeletal Muscle;skeletal muscle differentiation;Skeletal Muscle Satellite Cells;Structural Protein;support network;Syndrome;synergism;Testing;Therapeutic;Translating;United States;Utrophin;Work;X-linked Emery-Dreifuss muscular dystrophy

PROJECT_TITLE: Pathogenesis of Emery-Dreifuss Muscular Dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Mutations in the RNA splicing gene U2AF1 are commonly observed in Myelodysplastic syndromes (MDS). In this proposal, we will define the roles of U2AF1 mutations and co-occurring epigenetic mutations in the pathogenesis of MDS, and determine the molecular mechanisms of myelodysplasia induced by U2AF1 mutants. Results from these studies may lead to identification of new therapeutic approach for treatment of MDS.

PI_NAMEs: MOHI, GOLAM  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: 3' Splice Site;Acute Myelocytic Leukemia;Address;Anemia;Animal Model;Applications Grants;Binding;Biological;Biological Assay;Bone Marrow;bone marrow failure syndrome;Cell Cycle Checkpoint;Cell model;Cells;Characteristics;cytopenia;Data;DNA biosynthesis;DNA Damage;DNMT3a;driver mutation;Dysmyelopoietic Syndromes;Dysplasia;Ectopic Expression;Epigenetic Process;Erythroid;expectation;EZH2 gene;Gene Expression;Gene Mutation;Genes;Genetic Transcription;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;Heterozygote;in vivo;inhibitor;insight;knock-down;Knock-in Mouse;Length;Macrocytic Anemia;MAP Kinase Gene;MAP3K7 gene;Mitogen-Activated Protein Kinase Inhibitor;Molecular;mRNA Precursor;Mus;mutant;Mutant Strains Mice;Mutation;Myelogenous;Myeloid Cells;Neutropenia;new therapeutic target;novel;novel therapeutic intervention;p38 Mitogen Activated Protein Kinase;Pathogenesis;Patients;Play;progenitor;Protein Isoforms;proteogenomics;recruit;Regulator Genes;replication stress;response;Risk;RNA;RNA Splicing;Role;self-renewal;Somatic Mutation;Specificity;Spliced Genes;Spliceosomes;SRSF2 gene;synergism;Testing;TGF Beta Signaling Pathway;TGFBR2 gene;therapeutic evaluation;Thrombocytopenia;Transcript;U2 Small Nuclear Ribonucleoprotein;Zinc Fingers

PROJECT_TITLE: Molecular Basis for Myelodysplasia Induced by U2AF1 Mutations

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Infectious Diseases

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE The Engaging and Mentoring through Biomedical Research And Career Exploration (EMBRACE) project will increase the diversity of the biomedical research workforce through designing and implementing career development opportunities and research experiences for students and strategic professional development for faculty to better guide students on biomedical research careers. Students will participate in integrated research and career support activities organized longitudinally through the biology degree program, including a novel research experience sequence and career development resources, mentoring, and support. The desired outcome is to support a diverse group of undergraduate students and stimulate their interest, boost their self-efficacy, and provide strategies to pursue careers in biomedical research.

PI_NAMEs: LIBERLES, JESSICA  (contact);MCCARTNEY, MELISSA R

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Awareness;Bioinformatics;Biological Sciences;Biology;Biomedical Research;biomedical scientist;career;career awareness;Career Choice;career development;Career Exploration;career networking;career preparation;Communicable Diseases;Communication;Communities;Contingent Negative Variation;Degree program;demographics;design;Development;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Enrollment;Ensure;Environment;equity, diversity, and inclusion;Event;evidence base;experience;Faculty;faculty community;Florida;follow-up;Future;Hispanic;Hybrids;improved;innovation;Institution;Instruction;instructor;interest;International;Internships;Leadership;lens;Mentors;Modeling;novel;Outcome;pathogen;peer;peer coaching;Positioning Attribute;Preparation;Professional Competence;programs;Research;Research Activity;research and development;Research Personnel;Resource Development;Resources;Role;Science;Scientist;Self Efficacy;skills;STEM student;Strategic vision;student mentoring;student participation;Students;success;symposium;Teacher Professional Development;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: YOUNG JR., ALFORD A. (contact)

PROJECT_TERMS: Affect;Articulation;burnout;career;Career Mobility;Climate;cohort;Communication;Communities;comparison group;Competence;curriculum development;Data;Data Analyses;data management;data sharing;design;Development;Discrimination;Equilibrium;equity, diversity, and inclusion;Evaluation;experience;Faculty;Family;Future;Grant;Growth and Development function;harassment;Health Sciences;Immersion;improved;informant;insight;Institution;Intervention;Interview;Lead;Leadership;Measures;Mediator;meetings;Mentors;Mentorship;Methods;Michigan;Minority;Minority Groups;model design;organizational climate;Outcome;Participant;Peer Review;Perception;Positioning Attribute;pressure;Process;process improvement;Productivity;programs;Publications;Research Personnel;Resources;response;satisfaction;Self Efficacy;skills;Socialization;Source;Structure;success;Surveys;System;Teacher Professional Development;Time;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Well in self

PROJECT_TITLE: Evaluation Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Our 5-year clinical trial in 25,871 adults found promising effects of vitamin D for reducing cancer death and of marine omega-3 fatty acids for reducing myocardial infarction and total coronary heart disease. Further follow- up of study participants will allow an assessment of potential latent and long-term effects. Genetic and biochemical studies will help determine which individuals are most likely to benefit from supplementation.

PI_NAMEs: MANSON, JOANN ELISABETH (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: 25-hydroxyvitamin D;absorption;Address;adjudication;Adult;African American;African American population;Age;aged;Ancillary Study;Archives;Autoimmune Diseases;Biochemical;Biological Availability;Biological Markers;Black Populations;Blood;Blood specimen;Body mass index;Bone Diseases;bone health;cancer invasiveness;capsule;Cardiovascular Diseases;cardiovascular disorder risk;Cell membrane;Cessation of life;Cholecalciferol;Clinical;Clinical Trials;cognitive function;cohort;Cohort Studies;Colorectal Cancer;Coronary;Coronary heart disease;cost efficient;Data;data registry;Diabetes Mellitus;Diagnosis;dietary;Direct Costs;Disease;disorder prevention;DNA;DNA Methylation;Docosahexaenoic Acids;Dose;Eicosapentaenoic Acid;Erythrocytes;Event;Fish Oils;Fishes;follow-up;Funding;Future;Gene Expression;General Population;Genes;Genetic;Genetic Risk;genome wide association study;Health;high risk;Human;Impaired cognition;Incidence;indexing;Individual;Infrastructure;innovation;Intake;Intervention;intervention effect;Investigation;Knowledge;Learning;Life Style;Long-Term Effects;Magnesium;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;marine;matrix Gla protein;Measurement;Measures;Medical Records;Medicare;men;Metabolism;molecular marker;mortality;Myocardial Infarction;neoplasm registry;novel;Omacor;Omega-3 Fatty Acids;Osteocalcin;Participant;Phase;Placebo Control;Plasma;post intervention;prevent;Prevention;Primary Cancer Prevention;Protein Dephosphorylation;PTH gene;Public Health;racial diversity;Randomized;receptor function;Reporting;Research;Resources;revascularization;Risk Factors;Role;Sampling;Signal Transduction;Stage at Diagnosis;Stroke;Subgroup;Supplementation;Surveys;treatment duration;tumor;Uncertainty;United States Centers for Medicare and Medicaid Services;Update;Variant;Vitamin D;Vitamin D supplementation;Vitamin D-Binding Protein;Vitamin K;Vitamin K 1;Woman

PROJECT_TITLE: The VITamin D and OmegA-3 TriaL (VITAL): Post-Intervention Follow-Up

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: PROJECT NARRATIVE This proposal seeks to develop a new class of b-strand/sheet mimics capable of disrupting the aggregation of amyloid proteins. These compounds will be used to selectively target the fibrilization and transmission of toxic tau filaments from cell to cell. The research plan incorporates chemical synthesis, structural characterization, and biological evaluation of novel peptide and protein mimics to probe neurodegenerative protein assemblies.

PI_NAMEs: DEL VALLE, JUAN R (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adopted;alpha helix;Alzheimer's Disease;Alzheimer's disease patient;Amination;Amyloid;amyloid formation;Amyloid Proteins;Amyloidosis;aqueous;Area;beta pleated sheet;Binding;Biological;Biological Assay;Brain;Brain Diseases;Cells;Characteristics;chemical synthesis;Chemicals;corticobasal degeneration;Cryoelectron Microscopy;Cues;Data;design;Development;Diagnostic;Disease;DNA;Enzyme-Linked Immunosorbent Assay;Evaluation;Event;Excision;Exhibits;Face;Filament;flexibility;Fluorescence;Frontotemporal Dementia;Growth;Hydrogen Bonding;In Vitro;Inherited;inhibitor;interest;Lead;Libraries;Ligands;mimicry;Modeling;Modification;Molecular Conformation;Molecular Probes;Morphology;mutation screening;Nerve Degeneration;Neurodegenerative Disorders;neurotoxic;novel;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;Peptides;peptidomimetics;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Pick Disease of the Brain;Play;Polymorph;protein aminoacid sequence;Protein Conformation;protein folding;Protein Isoforms;protein protein interaction;protein structure;Proteins;Recombinants;Reporter;Research;Resistance;Resolution;Role;Scanning;Secondary Protein Structure;Series;Solid;solid state;Structure;Surface;System;tau aggregation;tau mutation;tau Proteins;Tertiary Protein Structure;Testing;Therapeutic;Translating;transmission process;Vertebral column

PROJECT_TITLE: Chemical approaches to selectively target beta-rich amyloids


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Alzheimer’s disease (AD) is a complex age-dependent disorder that requires multiple approaches to understand at a molecular level in order to develop novel diagnostics and disease modifying treatments. We will reveal how the major brain cell types (astrocytes and neurons) change at the protein level in AD and during aging and thus provide new targets for therapeutic and diagnostic strategies.

PI_NAMEs: KHAKH, BALJIT  (contact);VOSSEL, KEITH ALAN;WOHLSCHLEGEL, JAMES AKIRA

PROJECT_TERMS: Age;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Anatomy;Area;Astrocytes;Biotinylation;Brain;brain cell;Brain region;Cell membrane;cell type;Cells;Complex;Cytosol;Data;Dependovirus;diagnostic strategy;Disease;Electrophysiology (science);Evaluation;experimental study;Feedback;Functional disorder;Gene Expression;Hippocampus;Immunohistochemistry;Impaired cognition;Link;Location;Measures;Membrane Proteins;Methods;Molecular;molecular pathology;mouse model;Mus;Neuroanatomy;Neuroglia;neuroinflammation;Neurons;new therapeutic target;nonbinary;normal aging;novel diagnostics;Pathogenesis;pharmacologic;Phase;Physiology;Protein Dynamics;Proteins;Proteome;Proteomics;Reagent;Reporting;Risk;Seizures;Senile Plaques;Signal Transduction;Slice;tau mutation;translational potential;TREM2 gene;Wild Type Mouse;Work

PROJECT_TITLE: Astrocyte and neuron brain-region and compartment-specific proteome dynamics in aging and Alzheimer’s disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Women's Health Research

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Sexual minority women experience exceptionally high rates of mental health problems. This study aims to describe developmental trajectories of sexual minority women’s mental health across adolescence and young adulthood; identify risk and protective factors; and explore biological, psychological, and social/interpersonal mechanisms through which minority stress negatively affects mental health in this vulnerable population. Findings will inform the development of interventions to prevent and treat mental illness among sexual minority women. 1

PI_NAMEs: WHITTON, SARAH W (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Adolescence;Affect;Age;Anxiety;Anxiety Disorders;Attention;Behavioral;Biological;Biological Markers;Biological Process;Black race;Buffers;C-reactive protein;Childhood;cognitive process;Communities;Coping Skills;Data;Data Set;depressive symptoms;design;Development;Disparity;Economics;emerging adult;emotion regulation;evidence base;experience;Face;Family;family support;Feeling hopeless;Funding;Gender;Gender Identity;gender minority group;gender minority health;Goals;Grant;health disparity;health equity;Heterosexuals;Impairment;improved;Individual;Inflammatory;innovation;interest;Interleukin-10;Interleukin-6;Intervention;Knowledge;Latinx;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Longitudinal cohort study;Longitudinal Studies;Measurement;Mediating;men;Mental Depression;Mental disorders;Mental Health;Minority;minority stress;minority stressor;Modeling;multi-racial;National Institute of Child Health and Human Development;National Institute of Mental Health;non-heterosexual;nonbinary;Participant;Pathological anxiety;Pattern;Policies;prevent;Process;programs;prospective;protective effect;protective factors;psychologic;psychological symptom;Public Health;Race;racial diversity;Reporting;Research;Resources;Risk;Risk Factors;rumination;Sampling;Self-Injurious Behavior;Severities;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexual minority;sexual minority group;sexual minority health;sexual minority men;sexual minority women;Skin;social;Social isolation;Social Processes;social stigma;Strategic Planning;Stress;suicidal;Suicide;Symptoms;systemic inflammatory response;Testing;theories;therapy development;United States National Institutes of Health;Victimization;Violence;Vulnerable Populations;Woman;young adult

PROJECT_TITLE: Young Sexual Minority Women's Mental Health: Developmental Trajectories, Mechanisms of Risk, and Protective Factors.


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Heritable changes that can last for multiple generations without changing DNA sequence have been reported in many organisms, including humans. By focusing on the regulatory architectures that promote or prevent gene silencing in the nematode C. elegans, we will gain broadly applicable insights regardless of the particular molecules that mediate similar regulatory interactions in other systems. These insights will improve the diagnosis and treatment of hereditary diseases, especially those with an epigenetic origin in previous generations.

PI_NAMEs: JOSE, ANTONY MERLIN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Animals;Architecture;Biochemical;Biological;Biological Assay;Biological Models;Caenorhabditis elegans;Cell Nucleus;Cells;Chemicals;Chimeric Proteins;chromatin modification;Cytoplasmic Granules;Diagnosis;Disease;DNA Methylation;DNA Sequence;Double-Stranded RNA;Double-Stranded RNA Binding Domain;Epigenetic Process;Feedback;Foundations;Gene Expression;Gene Expression Regulation;Gene Silencing;Generations;Genes;Genetic;Germ Lines;Goals;Grant;Hereditary Disease;Heredity;Heritability;Hermaphroditism;Homologous Gene;Human;Hurricane;improved;insight;Licensing;male;Measurement;Measures;Mediating;Messenger RNA;Modeling;Modification;Molecular;Mutation;Nematoda;Oocytes;Open Reading Frames;Organism;outcome prediction;paralogous gene;Partner in relationship;Phase;piRNA;Predisposition;prevent;Production;Property;Proteins;psychological trauma;Regulation;Reporting;Resolution;response;RNA;RNA Binding;RNA Interference;RNA Stability;sensor;Sequence Homologs;Shapes;Signal Transduction;Site;Small RNA;Starvation;Stressful Event;Structure;Susceptibility Gene;System;Time;Transgenes;Transgenic Model;Water;Work

PROJECT_TITLE: Transgenerational gene silencing

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative: Pathologic Tau protein spreading in neurons and other brain cells significantly contribute to the disease progression and severity of Alzheimer's disease and other tauopathies. However, underlying mechanisms are poorly known and therapeutic strategies are lacking. This project aims to determine if lymphocyte-activation gene 3 (Lag3) is a receptor of pathologic tau fibrils and can be targeted to inhibit pathologic tau spreading for the treatment of tauopathies. Pre-clinical results from this project will provide a proof of concept of LAG3-targeted therapies using monoclonal antibodies for Alzheimer's disease and likely other tauopathies.

PI_NAMEs: MAO, XIAOBO  (contact)

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Antibodies;Astrocytes;Behavior;Behavioral;Binding;blood-brain barrier penetration;Brain;brain cell;brain dysfunction;cancer clinical trial;cancer immunotherapy;Cell Surface Receptors;Cells;clinical development;clinical translation;Clinical Trials;Data;Dependovirus;Development;Disease Progression;efficacy evaluation;Feedback;Gene Activation;Gene Deletion;Genetic;Genetic study;glial activation;Goals;Human;Immunologic Receptors;Impaired cognition;In Vitro;in vivo;Induced Neurons;Inflammation;Injections;insight;Knock-out;Knockout Mice;Knowledge;Lymphocyte Activation;Lymphocyte Depletion;Mediating;Mediator;Microglia;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Nerve Degeneration;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;neurotoxicity;neurotransmission;new therapeutic target;novel;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;Phagocytosis;Pharmacologic Substance;Play;pre-clinical;prion-like;Process;Proteins;receptor;receptor binding;Reporting;response;Role;Severity of illness;targeted treatment;tau aggregation;tau mutation;tau Proteins;Tauopathies;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;Time;translatable strategy;transmission process;Treatment Efficacy;uptake

PROJECT_TITLE: Mechanism of Pathologic Tau Fibrils Neuron-to-Neuron Transmission and Neuroinflammation in Alzheimer's Disease


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Our aim is to explore unitary principles of nervous system development. Using a simple invertebrate model system as a test case, we test here the hypothesis that an evolutionarily conserved class of transcription factors, called homeobox genes, are key specifiers over neuronal identity throughout the entire nervous system of an animal.

PI_NAMEs: HOBERT, OLIVER  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Alleles;Anatomy;Animals;Applications Grants;Assessment tool;Atlases;Bar Codes;Biological Models;Brain;C. elegans genome;Caenorhabditis elegans;Categories;Cells;Classification;Color;Communities;Complex;Defect;derepression;Embryo;Evolution;Excision;Family;Fingers;Gene Combinations;gene function;Genes;Genetic;genetic analysis;Genetic Markers;Homeobox;Homeobox Genes;homeodomain;Homeodomain Proteins;Individual;Invertebrates;Lead;loss of function;member;Molecular;mutant;Nematoda;Nervous System;nervous system development;neuron loss;Neuronal Differentiation;neuronal patterning;Neurons;novel;Pattern;Phenotype;postmitotic;programs;Proteins;Publishing;recruit;Reporter;Repression;Role;Scheme;Specific qualifier value;Testing;tool;transcription factor;Transgenic Organisms;Visualization;Zinc Fingers

PROJECT_TITLE: Homeobox Genes and Neuron Identity Control on a Brain-Wide Level

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative This project will develop a novel genetically engineered mouse strain in which a newly discovered super- enhancer that regulates the genes encoding the IL-33 and IL-18 receptors can be conditionally ablated in selected individual cell types. As this super-enhancer appears to impact the function of multiple immune cell types in disparate physiologic settings, this conditional super-enhancer knockout mouse will be a novel and versatile tool for studying the role of IL-33 and IL-18 in a variety of biomedically relevant models.

PI_NAMEs: ADLER, ADAM J;VELLA, ANTHONY T (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Agonist;Antigens;Asthma;Bacterial Infections;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Chromosome 1;Chromosome 2;Code;conditional knockout;CRISPR/Cas technology;cytokine;Data;Disparate;DNA;effector T cell;Endotoxins;Enhancers;Enterobacteria phage P1 Cre recombinase;Exhibits;Family member;FOXP3 gene;Future;Gene Expression;gene induction;Genes;Genetic Enhancer Element;Genetic Transcription;Genetically Engineered Mouse;genome editing;genome wide association study;homologous recombination;Host Defense;Human;Human Chromosomes;Hypersensitivity;IL18 gene;Immune;Immune response;Immunize;Immunotherapy;Impairment;Individual;Infection;Interferon Type II;Interleukin-1;Interleukin-12;interleukin-18 receptor;Interleukin-2;Knockout Mice;Ligation;Link;LoxP-flanked allele;Malignant neoplasm of lung;Measures;Mediating;Memory;Modeling;Molecular;Mouse Strains;Mus;Natural Killer Cells;novel;OX40;Parasitic infection;Pathology;Phenotype;Physiological;Process;promoter;Proteins;receptor;Regulatory T-Lymphocyte;Resistance;response;Role;Shock;Site;Squamous Cell Lung Carcinoma;T cell response;T-Cell Activation Pathway;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;tool;Transcription Initiation;Transgenic Organisms;tumor growth;Work

PROJECT_TITLE: Generating a novel conditional knockout mouse for a super-enhancer that controls cytokine responsiveness

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project has the potential to improve the science and implementation of app-based mobile health approaches to optimize both HIV testing and linkage to care as part of a single intervention continuum with MSM. The proposed research can provide evidence of the impact of this intervention approach on repeated HIV self-testing and linkage to care, and can hasten the translation of this approach to resource-limited areas in the US and elsewhere in the developing world where HIV testing and linkage to care services are sub- optimal.

PI_NAMEs: OPERARIO, DON  (contact);YANG, CUI

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: 2 arm randomized control trial;Adherence;Age;AIDS prevention;behavior change;behavior test;Behavioral;Behavioral Mechanisms;Behavioral Model;care outcomes;care systems;Caring;Characteristics;China;Cities;Clinic;Communication;Consolidated Framework for Implementation Research;Continuity of Patient Care;Control Groups;Coping Skills;cost;Country;Cultural Sensitivity;Data;Development;Disclosure;Early Diagnosis;Education;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;efficacy evaluation;Excision;follow-up;Goals;Grant;Health;Health Promotion;Health Services;High Prevalence;high risk men;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;home test;Human immunodeficiency virus test;hybrid type 1 design;implementation evaluation;implementation intervention;improved;Individual;Infection;informant;innovation;Intervention;intervention effect;Link;Maps;Measures;Mediation;men who have sex with men;mHealth;mhealth interventions;minority stress;mobile application;Motivation;National Institute of Mental Health;Outcome;Participant;Persons;Photography;Pilot Projects;pilot test;Population;Prevention;prevention service;primary outcome;Privatization;Process;Professional counselor;Qualitative Evaluations;Qualitative Research;recruit;Research;Resource-limited setting;Risk;Risk Reduction;same sex behavior;scale up;Science;secondary outcome;Secure;Self Efficacy;self testing;Services;sexual risk behavior;Site;social stigma;Strategic Planning;Test Result;Testing;testing services;testing uptake;theories;Time;translational approach;transmission process;Treatment Efficacy;treatment services;United States National Institutes of Health;uptake;user centered design;Visual;willingness;Work

PROJECT_TITLE: Mobile Health Intervention to Increase HIV Self Testing and Linkage to Services for High-Risk Men in China

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE Although poly(ethylene glycol) (PEG) hydrogels are widely regarded as biologically inert materials, mounting evidence suggests that a significant percentage of the population is primed for an immune response against this polymer. In this project, we will study how an anti-PEG immune response affects the compatibility of PEG hydrogels and determine the extent to which variations in the properties of the hydrogel affect susceptibility to negative outcomes.

PI_NAMEs: ALGE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acrylamides;adaptive immune response;Address;Adhesives;Affect;Alkynes;Animal Model;Animals;Antibodies;Azides;Biocompatible Materials;biomaterial compatibility;Blood Tests;Cell Adhesion;Cell secretion;Cell Therapy;Cells;chemical property;Chemistry;Complement Activation;Cosmetics;crosslink;design;Drug Delivery Systems;Enzymes;Esters;ethylene glycol;experimental study;Exposure to;Flow Cytometry;Foreign Bodies;Formulation;Funding;Future;Histology;Hydrogels;Immune;Immune response;Immunize;immunogenic;immunogenicity;Immunohistochemistry;Immunologics;Immunology;Implant;implantation;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;inflammatory marker;Infusion procedures;interest;intravenous administration;Investigation;Knowledge;Ligands;Longitudinal Studies;Magnetic Resonance Imaging;Marketing;Medical Device;methacrylamide;Modulus;Mus;non-invasive imaging;Outcome;patient screening;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;physical property;Polymers;Population;Predisposition;Property;Proteins;Reporting;Research;response;Risk;Safety;Study of magnetics;subcutaneous;Sulfhydryl Compounds;Testing;Therapeutic;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Genetics;Neurosciences;Nutrition

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Metabolic waste accumulation due to meningeal disruption has been linked to the onset of neurodegeneration, increased incidence of stroke, altered vascular permeability, cognitive decline, and lower recovery from brain injury. Expanding our understanding of the integral cell populations comprising the meninges and the pathways regulating their development and function will help elucidate genetic mechanisms affecting meningeal and CNS stability during disease.

PI_NAMEs: VENERO GALANTERNIK, MARINA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adult;Affect;Age;age effect;Aging;Anatomy;Animal Feed;animal old age;Animals;Bathing;Biochemical;Biological Assay;Blood Vessels;Brain;Brain Injuries;Buffers;Cell Culture Techniques;cell type;Cells;Cellular Structures;Central Nervous System;Cerebrospinal Fluid;Circulation;Complex;confocal imaging;Connective Tissue;Defect;design;Development;Developmental Biology;Diet;Disease;Electron Microscopy;Embryo;Endothelium;Environment;ependymins;Excision;Experimental Models;extracellular;Fatty acid glycerol esters;Fishes;Functional disorder;Future;Gene Expression;Genes;Genetic;grasp;high resolution imaging;Histology;Homeostasis;Image;Impaired cognition;In Vitro;in vivo;Infection;Injury;insight;Knowledge;Label;Link;Liquid substance;Lymphatic System;Macrophage;Maintenance;Mechanics;Meningeal;Meninges;Metabolic;Modeling;Molecular;Morphology;Mutagenesis;mutant;Nerve Degeneration;Neurocognitive;Neurons;novel;Obesity;pathogen;Pathogenicity;Pathway interactions;Pericytes;Phase;Play;Population;Positioning Attribute;prevent;Process;programs;Property;Recovery;Regulation;Research;research faculty;Resolution;response;RiboTag;Role;Shock;Signal Transduction;single-cell RNA sequencing;Site;stroke incidence;Structure;System;tenure track;Tissues;tool;transcriptome sequencing;Transgenic Animals;Transgenic Organisms;Transmission Electron Microscopy;uptake;Vascular Permeabilities;Vascular System;Vascularization;wasting;Zebrafish

PROJECT_TITLE: Mechanisms regulating Meningeal Development and Function


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Voltage-gated Kv7/KCNQ potassium channels require membrane lipid cofactor PIP2 to open and calmodulin to traffic to the neuronal axons where they potently suppress repetitive and burst firing of action potentials. This proposal will identify the PIP2 binding sites that change by different gating states, subunit composition, and calmodulin binding of Kv7 channels, thereby controlling their axonal enrichment and function to reduce neuronal excitability. In contrast to a well-established role of PIP2 in gating modulation, this project will provide novel concepts that the PIP2 binding landscape is dynamic and modulates both function and trafficking of axonal Kv7 channels to impact neuronal excitability and the mechanisms of pathogenic variants in Kv7 subunits that cause epilepsy.

PI_NAMEs: CHUNG, HEE JUNG  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TITLE: Dynamic changes in PIP2 binding sites and their impact on axonal targeting and function of epilepsy-associated KCNQ/Kv7 channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-G(06)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Reperfusion injury is a common pathology that can occur after restoration of blood flow to ischemic heart muscle. This proposal seeks to develop and investigate non-invasive cardiovascular magnetic resonance imaging and positron emission tomography approaches to detect reperfusion injury in vivo and assess their prognostic value for adverse remodeling of the heart.

PI_NAMEs: BRAVO, PACO E.;WITSCHEY, WALTER R.T. (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute myocardial infarction;Affect;analog;Animal Model;Animals;Anterior Descending Coronary Artery;Arrhythmia;Arteries;Biological Assay;Blood flow;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiovascular system;catalyst;Catheters;Cause of Death;Cell Death;cell injury;Chronic;Clinical;clinical care;Coagulation Process;Complication;Computed Tomography Scanners;Coronary artery;Coronary heart disease;Data;Deposition;Development;Diagnosis;dihydroethidium;Discipline of Nuclear Medicine;Disease;Edema;EFRAC;Erythrocytes;Event;experience;experimental study;Extravasation;Failure;Family suidae;Fibrosis;fluorescence imaging;Fluorine;Glutathione;Goals;Heart;Heart failure;heart imaging;hemodynamics;Hemorrhage;High Prevalence;high risk;Human;Image;imaging biomarker;imaging modality;Imaging Techniques;Immunohistochemistry;Impairment;improved;in vivo;in vivo imaging;Infarction;Injury;Intervention;Iron;Iron-Binding Proteins;Ischemia;Label;Left;Left Ventricular Function;Left Ventricular Mass;Left Ventricular Remodeling;Lipid Peroxidation;Macrophage;Magnetic Resonance Imaging;Maps;Measures;method development;Methods;Molecular;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial perfusion;Myocardial Reperfusion;Myocardial Reperfusion Injury;Myocardium;non-invasive imaging;novel;Outcome;Pathology;patient prognosis;Patients;percutaneous coronary intervention;Pharmaceutical Preparations;Physicians;Positron-Emission Tomography;Procedures;Production;prognostic value;Proteins;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Research Personnel;restoration;Risk;Rubidium;Series;Severities;spatiotemporal;Specificity;Spectrometry;standard care;Structure;success;Surgeon;System;targeted treatment;Techniques;Testing;Therapeutic;Thick;Thrombolytic Therapy;tool;translational goal;uptake;Validation;Ventricular;Ventricular Remodeling;wound healing

PROJECT_TITLE: Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarction

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Approximately 40 million people worldwide are living with HIV/AIDS, and a protective vaccine or functional cure has been elusive despite four decades of extensive research. The proposed Duke Consortium for Innovative HIV/AIDS Vaccine and Cure Research (CIAVCR) program will provide new insights into the effects of vaccine-induced polyfunctional protective immune responses on eliminating HIV latent reservoirs. The ultimate goal of these studies is to develop an effective combined immunotherapeutic regimen for HIV-1 prevention and cure using the non-human primate (NHP) model that provides a direct path into the clinic for use in humans.

PI_NAMEs: FERRARI, GUIDO ;WILLIAMS, WILTON B (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Animals;Antibody Response;antibody-dependent cell cytotoxicity;Antibody-mediated protection;Antigens;antiretroviral therapy;Autologous;B-Lymphocytes;Bar Codes;Binding;booster vaccine;CD8-Positive T-Lymphocytes;Characteristics;Clinic;Clinical Research;Clinical Treatment;Collaborations;Complex;COVID-19 pandemic;COVID-19 prevention;cytotoxic;Data;design;Development;Diagnosis;Disease;efficacy evaluation;Epidemic;Generations;global health;Goals;Grant;Health Priorities;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV vaccine;HIV-1;Human;Immune response;Immunity;Immunoglobulin G;Immunology;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infection;Infusion procedures;innovation;insight;Interruption;latent HIV reservoir;Licensing;Messenger RNA;Modeling;Monoclonal Antibodies;nanoparticle;Natural Killer Cells;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel;novel strategies;novel therapeutics;novel vaccines;operation;Outcome;pandemic disease;Peptides;Persons;Plasma;pre-clinical;prevent;Prevention;Prevention approach;Preventive;Process;programs;Recombinants;Regimen;Research;Research Personnel;Resources;response;RNA vaccine;Role;Sampling;Sequence Analysis;simian human immunodeficiency virus;success;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic vaccine;Universities;vaccination strategy;vaccine effectiveness;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;vaccine-induced immunity;Vaccines;Variant;Viral load measurement;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative To fully understand how we hear, and develop effective treatments for hearing deficits, requires knowledge of multiple disciplines, such as biology, medicine and engineering. This program trains junior scientists to be experts in one discipline and familiar with several, so that they are able to focus the tools and techniques of multiple disciplines on the problems to be solved.

PI_NAMEs: METHERATE, RAJU  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Hearing;National Institute on Deafness and Other Communication Disorders;Research;Training Programs

PROJECT_TITLE: NIDCD T32 Interdisciplinary Training Program in Hearing Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PHR: Primary progressive aphasia (PPA) is a degenerative condition of language loss that affects many patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD) and for which there are no effective treatments. The inability to access names of objects, or anomia, is one of the most common, burdensome deficits associated with PPA, and while promising early evidence suggests that a noninvasive neuromodulation technique called transcranial direct current stimulation (tDCS) may be helpful in treating anomia, progress toward bringing this treatment into widespread clinical use is hampered by the absence of large, convincing, multi-site clinical trials. The current project addresses this gap by conducting the world's first well-powered Phase 2 clinical trial of tDCS therapy in PPA, in order to more definitively determine whether tDCS paired with behavioral naming treatment results in lasting improvement in naming ability and also to identify the characteristics of persons with PPA for whom treatment with tDCS is most likely to be effective. Project Narrative

PI_NAMEs: HAMILTON, ROY H (contact);TSAPKINI, KYRANA

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Affect;Aftercare;Age;Aging;Alleles;alternative treatment;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Anomia;Aphasia;Area;arm;Atrophic;Attention;BDNF gene;behavior test;Behavioral;bilingualism;Biological;Brain;Brain imaging;Canada;Characteristics;Clinical;Clinical effectiveness;clinical practice;Clinical Research;clinical translation;Clinical Trials;Cognitive;cognitive control;cohort;Collaborations;Communication;computerized;Crossover Design;Degenerative Disorder;Disease;Double-Blind Method;effective therapy;experience;Failure;Frontotemporal Dementia;Genetic Polymorphism;Goals;Health Sciences;Image;Impairment;improved;Inferior;International;Intervention;Investigation;Language;Language Disorders;Language Therapy;Left;Magnetic Resonance Imaging;Measures;Membrane Potentials;Multi-Institutional Clinical Trial;Names;neural;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurons;neuroregulation;Nonpharmacologic Therapy;North America;novel;novel therapeutics;older adult;Oral;Outcome;Parietal;Participant;patient population;Patients;Pennsylvania;Performance;Persons;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Pilot Projects;Placebos;Population;Positioning Attribute;Prevalence;prevent;primary outcome;Primary Progressive Aphasia;Production;Progressive Aphasias;Progressive Nonfluent Aphasias;Publishing;Randomized;remediation;Research;Research Personnel;response;Rest;Risk;Severities;sex;Site;spelling;success;symptom treatment;Synaptic plasticity;Synaptic Transmission;Syndrome;targeted treatment;Techniques;Testing;Therapeutic;Thick;transcranial direct current stimulation;Universities;Variant;Work;Writing

PROJECT_TITLE: Phase II clinical trial of transcranial direct current stimulation in the treatment of primary progressive aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Diabetes;Rehabilitation;Wound Healing and Care

ORG_CITY: McLean

ORG_NAME: XYKEN, LLC

PHR: Project Narrative  The proposed mobile solution to be developed under this SBIR project will be the first clinical tool that utilizes a mobile device to capture detailed foot 3D shape dynamics for in-office customization and rapid prototyping of foot orthotics. The unique data acquisition and optimization framework has many advantages over existing practice in the podiatric industry. We foresee the proposed solution will have a reasonably large market share in the rapidly growing multi-billion dollar foot ulceration care industry due to the growing aging population.

PI_NAMEs: YI, STEVEN  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: 3-Dimensional;3D Print;Academy;Address;Adopted;Adult;Age;aging population;Algorithms;American;Ankle;biomechanical model;biomechanical test;Biomechanics;Bypass;Caring;Cellular Phone;Chronic;Clinical;Collaborations;compare effectiveness;Computer software;Consumption;cost;Custom;data acquisition;design;design verification;Development;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;diabetic ulcer;digital models;Disease;Elderly;Elements;Evaluation;experience;fabrication;Finite Element Analysis;foot;Foot Ulcer;Generations;Goals;Hand;handheld mobile device;Heel;Image;impression;improved;Income;Industry;Laboratories;Light;Location;Manufacturer;Marketing;Medial;Medicine;Methods;mobile computing;Modeling;Motion;Orthotic Devices;Pain;Pathology;Patients;Phase;Population;Positioning Attribute;Posture;pressure;prevent;Prevention;Process;Production;programs;prototype;reconstruction;Recurrence;recurrence prevention;Refit;Scanning;Schools;Shapes;Shoes;simulation;Site;Small Business Innovation Research Grant;smartphone application;Spottings;Stress;Structure;Surface;System;Systems Development;Testing;Three-Dimensional Imaging;Time;tool;Treatment Cost;United States National Institutes of Health;Universities;Weight-Bearing state

PROJECT_TITLE: A low cost and effective foot orthotics fabrication framework


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative Despite high prevalence rates of mental illness in youth, most U.S. youth with mental health need do not receive mental healthcare, with the disparity in need and service use highest among racial/ethnic minority and socially disadvantaged families. Psychoeducation, which provides information about mental health problems and treatment options, has emerged as a promising tool for engaging families in mental healthcare. To achieve health equity, a Psychoeducation Toolkit that contains evidence-based, culturally responsive elements will be co-developed with community stakeholders to engage underserved families in mental healthcare.

PI_NAMEs: MARTINEZ, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;barrier to care;Belief;Cognitive;Communities;community partners;Consolidated Framework for Implementation Research;County;Data;design;Development;disadvantaged background;Disparity;Doctor of Philosophy;effective therapy;Elements;ethnic minority;evidence base;Family;First Generation College Students;Funding Mechanisms;Future;Goals;health equity;health literacy;Health system;help-seeking behavior;High Prevalence;Hispanic-serving Institution;implementation barriers;implementation efforts;implementation evaluation;implementation outcomes;Knowledge;Measures;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;Modeling;Nature;programs;Provider;psychoeducation;psychologic;racial minority;Randomized, Controlled Trials;Research;Services;social disparities;social stigma;Spanish;Spanish/English;student participation;theories;tool;Translating;Underrepresented Populations;Underrepresented Students;Visual;Work;Writing;Youth

PROJECT_TITLE: Co-Developing a Psychoeducational Mental Health Toolkit for Underserved Families to Navigate the Mental Health System


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Memory CD8 T cells can provide immunity against infections and tumors, and improving their generation is a major goal of vaccination and immunotherapy. This project aims to understand how a highly functional subset of circulating memory CD8 T cells contributes to sterilizing immunity. Our goal is to understand the strengths and weaknesses of this population and to use this knowledge to enhance memory T cell persistence and function.

PI_NAMEs: HAMILTON HART, SARA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: acute infection;Adoptive Transfer;Affect;Antigen Presentation;Antigens;Apoptosis;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;CD94 Antigen;Cell Compartmentation;Cell Count;Cell Physiology;Cells;Characteristics;chemokine;chronic infection;CRISPR/Cas technology;Cues;Cytokine Receptors;Data;Effector Cell;Endothelial Cells;Endothelium;engineered T cells;Excision;experience;Extravasation;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;germ free condition;Goals;Homing;Human;IFNAR1 gene;Immune response;Immunity;Immunization;immunopathology;Immunotherapy;improved;in vivo;Infection;Inflammation;Inflammatory;innovation;Knowledge;Ligands;Location;Lung;Maintenance;Measures;Mediating;Memory;Microbe;microbial;mouse model;Mus;Natural Killer Cells;neoplastic cell;novel;pathogen;pathogenic bacteria;pathogenic virus;Phase;Population;Positioning Attribute;prevent;Process;Property;receptor;response;Rest;Signal Transduction;single-cell RNA sequencing;Site;Splenic Red Pulp;Stream;T memory cell;T-Lymphocyte;Testing;Time;Tissues;trafficking;transcriptome sequencing;tumor;Up-Regulation;Vaccination;Vascular Endothelial Cell;Work

PROJECT_TITLE: Understanding the functional agility of effector memory CD8 T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: Carlsbad

ORG_NAME: ARISAN THERAPEUTICS, INC.

PHR: Narrative The emergence and dissemination of natural or engineered pathogens causing excessive morbidity and/or mortality have the potential for the widespread disruption of world economies and public healthcare systems. The primary goal of this proposal upon completing several key studies is to advance an IND package to the FDA for the treatment of Lassa Virus Fever that also provides a tractable initial indication to provide a broad-spectrum arenavirus entry inhibitor as an oral therapeutic treatment.

PI_NAMEs: HENKEL, GREGORY WILLIAM (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acceleration;Adopted;Africa;Anemia;animal efficacy;Anti-viral Agents;Arenavirus;Autopsy;Autoradiography;Bile fluid;Body Fluids;Canis familiaris;Cardiac;Category A pathogen;Cells;Clinical;Clinical Research;cohort;Death Rate;Development;Dimethyl Sulfoxide;Disease;Dose;Drops;Drug or chemical Tissue Distribution;Embryo;Engineering;enzyme activity;Equilibrium;Excretory function;Exhibits;Eye;Family;Feces;Female;fetal;flu;Formulation;Future;Genes;Geography;Glycoproteins;Goals;Healthcare Systems;healthy volunteer;Hemorrhage;Hepatocyte;Hospitalization;Human;In Vitro;in vivo;Incubated;Industry;infected vector rodent;Infection;Ingestion;Inhalation;inhibitor;intravenous administration;Label;Lassa;Lassa Fever;Lassa virus;manufacture;Modeling;Morbidity - disease rate;mortality;mRNA Expression;Mutation;nanomolar;Nose;Old World Arenaviruses;Oral;Oryctolagus cuniculus;Pain;patch clamp;pathogen;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;pill;Placebo Control;Plasma;pre-clinical;pregnant;product development;Property;prophylactic;Public Health;Radio;Radiolabeled;Rattus;reproductive toxicity;Respiratory distress;Ribavirin;Risk;Risk Assessment;Rodent;Safety;Sampling;scale up;Shock;side effect;South America;Survivors;Swelling;Symptoms;Therapeutic;Thrombocytopenia;Time;Tissues;Toxic effect;transmission process;Transplantation;Treatment Efficacy;Urine;Vero Cells;Viral;Viral Hemorrhagic Fevers;viral resistance;virology;Virus Diseases;Vomiting;weapons;Western Africa;Zoonoses

PROJECT_TITLE: IND-Enabling Studies for Arenavirus Preclinical Candidate


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Microbial production of fucosylated human milk oligosaccharides Human milk oligosaccharides are potent bioactive compounds that modulate neonatal health and are of interest for development as potential drug treatments for adult diseases. The potential of these molecules, their limited access from natural sources, and difficulty in large-scale isolation of individual HMOs for studies and applications have motivated the development of novel production strategies. In this proposed project, we will establish a strategy for efficient and cost-effective production of fucosylated lacto-N-tetraoses (LNTs) such as LNFP II, LNFP I, and LNDFH I from lactose and L-fucose in live engineered Escherichia coli cells.

PI_NAMEs: ATSUMI, SHOTA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adult;Anti-viral Agents;antimicrobial;Bacteria;Binding;Biological Process;Carbohydrates;Cells;Chemicals;Child;Collaborations;Colostrum;Complex;cost;cost effective;cytotoxicity;density;Derivation procedure;Development;Disease;Engineering;Entamoeba histolytica;Enzymes;Epithelial Cells;Escherichia coli;Fucose;Fucosyltransferase;Future;Galactose;Galactosides;Genes;glycosylation;Guanosine Diphosphate Fucose;Helicobacter Infections;Helicobacter pylori;Human;Human Milk;human milk oligosaccharides;Hydrophobicity;Immune;improved;In Vitro;Individual;Industrialization;Infant;Inflammatory;innovation;interest;intestinal epithelium;Lactose;Link;Mammals;Methods;microbial;microbial host;microorganism;Milk;mutant;Natural Source;neonatal health;novel;novel strategies;Optics;overexpression;Pathway interactions;Pharmacotherapy;Polysaccharides;prebiotics;prevent;Process;Production;Reaction;response;Secretor blood group alpha-2-fucosyltransferase;Site;Structure;synthetic biology;System;Therapeutic;tool;Uridine Diphosphate Galactose

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Amyotrophic Lateral Sclerosis (ALS) patients usually have symptoms starting in one part of the body with weakness spreading rapidly over time to other regions. We believe that this disease spread may be mediated by astroglia through the hemichannel-mediated release of factors into the extracellular environment that results in motor neuron death. This project will investigate the pathways by which hemichannels on ALS astrocytes cause this toxicity and will investigate a pharmacologic therapeutic strategy for blocking hemichannels by utilizing novel ALS human iPS cells and rodent models.

PI_NAMEs: MARAGAKIS, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Astrocytosis;Autopsy;Behavioral;Biological Markers;Biology;Blood Vessels;blood-brain barrier penetration;Body part;Brain;Buffers;Cell model;Cells;Central Nervous System;Cessation of life;Chronic;Clinical;clinical phenotype;Clinical Trials;Coculture Techniques;Complement;Connexin 43;Connexins;Cortical Cord;Coupled;Data;design;Development;Diagnosis;Disease;disease phenotype;Disease Progression;Dose;Electrophysiology (science);Environment;epigenomics;Event;extracellular;frontal lobe;Functional disorder;Gap Junctions;Glutamates;Human;human induced pluripotent stem cells;human tissue;Hyperactivity;In Situ;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;insight;Knock-out;Learning;Libraries;Link;Measures;Mediating;Membrane;Metabolic;metabolomics;Modeling;Motor Neurons;mouse model;multi-electrode arrays;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;Oral;Pathologic;Pathway interactions;patient population;Patients;pharmacologic;Physiology;Probability;Property;Proteins;Proteomics;Publications;Publishing;Regional Anatomy;Regulation;release factor;Reporting;repository;Rodent Model;Safety;Spinal Cord;superoxide dismutase 1;Symptoms;Synapses;Testing;Therapeutic;Time;Tissues;Toxic effect;transcriptomics;Translating;translational applications;translational potential;Treatment Efficacy

PROJECT_TITLE: Modulating an Astrocyte Hemichannel to Delay Spatial and Temporal Progression in ALS.

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]