ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE NICHD established the Neonatal Research Network (NRN) to investigate persistent unanswered questions regarding the safety and efficacy of treatment and management strategies for newborn infants. RTI, as the NRN Data Coordinating Center (DCC) since 1988, is uniquely positioned to provide support to the Feeding in Premature Infants Working Group and will pull from a highly experienced bench of DCC coordinators who are up-to-date on the latest advances in neonatal research. RTI, as the NRN DCC, will provide support to the Feeding in Premature Infants Working Group and will draft a report on behalf of the Working Group.

PI_NAMEs: DAS, ABHIK  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Caring;Clinical Research;Data Coordinating Center;experience;feeding;Follow-Up Studies;Group Meetings;Healthcare;Hospitals;Infant;Lead;Multicenter Neonatal Research Network;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;Newborn Infant;Outcome;Positioning Attribute;Premature Infant;Reporting;Research;Review Literature;Safety;symposium;Treatment Efficacy;working group

PROJECT_TITLE: Neonatal Research Network Data Coordinating Center (DCC) 2023-2028


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Neurosciences;Pediatric

ORG_CITY: CHESTNUT HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Brain Healthy will engage students from diverse backgrounds in citizen science investigations of their own brain health and wellness, which is particularly relevant given COVID-related increased concern about mental health and well-being. The program will expose students to data science (a new area of major SEPA interest) and topics such as brain plasticity and stress management (which are tightly related to NIH-funded research) and will allow students to explore the relations between healthy lifestyle practices (e.g., physical exercise) and cognitive/affective measures. Through this experience, students will not only increase their conceptual understanding of the brain basis of healthy lifestyle choices, but they will also acquire important and widely applicable data analytic and communication practices.

PI_NAMEs: DAVIDESCO, IDO  (contact);SUZUKI, WENDY A.

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Affective;Area;Attitude;Award;Awareness;Biology;biomedical data science;Brain;brain health;career;citizen science;Cognitive;cohort;Communication;Communities;community science;computerized;Connecticut;course development;COVID-19;COVID-19 pandemic;Data;Data Analyses;Data Analytics;Data Collection;data communication;Data Science;Data Set;data visualization;Databases;design;education research;Educational Curriculum;Educational Materials;Ensure;Ethnic Population;Evaluation;Exercise;experience;Feedback;fitness;Funding;Goals;Grant;Health;healthy lifestyle;Heart Rate;high school;improved;interest;Interview;Intuition;Investigation;Leadership;Learning;Life Experience;Life Style;literacy;Measures;Mental Health;Mentors;minority communities;Moods;multidisciplinary;Neurosciences;New York;New York City;Next Generation Science Standards;ninth grade;open source;pedagogy;peer coaching;Personal Satisfaction;Physical Exercise;Principal Investigator;Process;programs;racial population;recruit;Research;Research Project Grants;research study;scaffold;School Teachers;Schools;Science;science education;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Self Efficacy;skills;sleep quality;social media;STEM career;Stress;stress management;Structure;student mentoring;student participation;Students;success;Surveys;teacher;tenth grade;Time;Underrepresented Populations;Underrepresented Students;underserved community;United States National Institutes of Health;Universities;web interface;web platform;Wellness Program;Work;Youth

PROJECT_TITLE: Brain Healthy: Engaging Students in Citizen Science Brain Health and Wellness Investigations to Promote Data Science Literacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ACTIVITY: ZIA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: BARON, JEFFREY  (contact)

PROJECT_TERMS: Affect;Age;Aging;Appearance;Binding;bone;Bone Diseases;Bone Growth;bone turnover;BRF1 gene;C-Type Natriuretic Peptide;Cartilage;Child;Childhood;Chondrocytes;Chondrogenesis;Clinical;Complex;Development;Differentiation and Growth;Disease;Disparity;Endocrine;Endosomes;Epigenetic Process;Epiphysial cartilage;Estrogens;Etiology;Evaluation;exome sequencing;Extracellular Matrix;Face;Facies;Failure;Family;Family Study;Fibroblast Growth Factor;Genes;Genetic;Genetic Diseases;genetic variant;Glucocorticoids;Goals;Growth;Growth and Development function;Growth Disorders;Height;histone modification;Human;Human Genetics;Impairment;In Vitro;Inherited;Inhibition of Cell Proliferation;insight;Laboratories;Length;Life;Link;malformation;medical attention;member;MicroRNAs;Molecular;Molecular Abnormality;Mutation;paracrine;parathyroid hormone-related protein;Pathway interactions;Play;programs;Reader;receptor;Regulation;research clinical testing;retinoic acid 4-hydroxylase;Retinoids;Role;Signal Transduction;skeletal;skeletal dysplasia;Syndrome;System;Thinness;Tissues;trafficking;transcription factor;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: Regulation Of Childhood Growth


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Eating Disorders;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: YANOVSKI, JACK A. (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adolescent;Adult;adult obesity;Agonist;Anxiety;attentional bias;Autophagocytosis;Bardet-Biedl Syndrome;Behavior;Behavioral;behavioral phenotyping;Binge Eating;Body Composition;Body fat;Body mass index;Body Weight;Body Weight decreased;Bone Tissue;Brain-Derived Neurotrophic Factor;C-reactive protein;capsule;cell type;Cells;Characteristics;Child;Childhood;Choline;clinical translation;Colchicine;comorbidity;COVID-19 pandemic;Data;Data Collection;Development;Diazoxide;Disease;Disease remission;Disinhibition;DNA Sequence Alteration;Eating;Eating Behavior;Effectiveness;efficacy evaluation;endophenotype;energy balance;Energy Intake;Environmental Risk Factor;Erythrocyte Sedimentation Rate;Etiology;expectation;experience;Fasting;Fatty acid glycerol esters;fecal microbiome;feeding;Female Adolescents;follow-up;Food;Future;Gastrectomy;GCG gene;gene function;Genes;Genetic;Genetic Polymorphism;genetic variant;girls;Glucose;Goals;Growth;Health;Health education;Hepatic;Hepatocyte;Heterozygote;High Density Lipoprotein Cholesterol;Human;Hyperphagia;Impairment;improved;Individual;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;interpersonal therapy;Intervention;Investigation;Knock-in Mouse;Knock-out;LDL Cholesterol Lipoproteins;Leptin;leptin receptor;Leptin receptor mutation;Leptin resistance;Link;Longitudinal cohort;loss of control over eating;LoxP-flanked allele;Measures;Mesenchymal Stem Cells;Metabolic;metabolic phenotype;Metabolic syndrome;Metabolism;Modeling;Mononuclear;Mus;mutant;negative affect;neutrophil;novel;novel therapeutics;Nutrient;obese person;Obesity;obesity development;obesity genetics;obesity in children;obesity risk;obesity treatment;open label;Overweight;Patient Self-Report;Patients;peer;Peripheral;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Physiology;Pilot Projects;placebo group;Placebos;Population;Prader-Willi Syndrome;precision medicine;Predictive Factor;Prevalence;prevent;Prevention strategy;programs;Protocols documentation;psychologic;Psychological Factors;Psychological reinforcement;Psychology;Publications;Randomized;randomized, controlled study;receptor;Regulation;Reporting;Risk;Risk Marker;Role;Sampling;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Smith Magenis syndrome;Social Adjustment;socioeconomics;stem cell differentiation;Syndrome;therapy development;Tissues;Training;trait;Translational Research;Translational trial;treatment strategy;Triglycerides;United States;United States Food and Drug Administration;Variant;Weight;Weight Gain;White Blood Cell Count procedure;Withdrawal;Work;WT1 gene;Youth

PROJECT_TITLE: Physiology, Psychology, and Genetics of Obesity


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PI_NAMEs: CHEN, M.D., MPH, BEATRICE  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - MAGEE


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: CLIFTON

ORG_STATE: VA

PHR: Subject matter expert support for developing non-addictive therapies for pain.

PI_NAMEs: MISHRA, SOMNATH  (contact)

PROJECT_TERMS: analytical method;assay development;authority;Chemicals;Chemistry;Chronic;chronic musculoskeletal pain;clinical pain;Clinical Research;Conduct Clinical Trials;Contracts;design;Development;Dose;Drug Kinetics;drug metabolism;Electronic Mail;Ensure;European;Experimental Designs;Feedback;Formulation;Guidelines;Helping to End Addiction Long-term;Human;improved;International;Investigational Drugs;Knee Osteoarthritis;Lead;lead optimization;manufacture;Marketing;Medicine;member;method development;Methodology;National Institute of Neurological Disorders and Stroke;novel;Opiate Addiction;Pain;Pain management;Perioperative;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy (field);Preparation;Process;product development;programs;Quality of life;Recommendation;Reporting;Research Contracts;Risk;Role;Science;Services;small molecule;Speed;symposium;Telephone;United States National Institutes of Health;Visit

PROJECT_TITLE: PHARMACEUTICS/FORMULATION/CMC CONSULTING SERVICES FOR NINDS HEAL PROGRAM


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: KERNS, JENNIFER   (contact)

PROJECT_TERMS: Clinical;Clinical Trials Network;Communication;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Contractor;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;Performance;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;Time;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - UCSF


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

ORG_STATE: MD

PI_NAMEs: MALLOY, DAVID  (contact)

PROJECT_TERMS: Address;Contracts;Development;Documentation;flexibility;HIV;HIV vaccine;Investigational Drugs;National Institute of Allergy and Infectious Disease;Phase;pre-clinical;Preclinical Testing;Process;product development;Production;programs;research clinical testing;Services;vaccine development;Vaccines

PROJECT_TITLE: Preclinical and Translational Vaccine Development Support for HIV and Other Candidate Agents: Scientific, Quality and Regulatory Support Services


ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PHR: The public health relevance of this contract includes addressing research gaps in the field of neuroHIV by examining the epidemiological and pathophysiologic mechanisms of HIV-1 associated CNS disease outcomes, persistence of HIV-1 viral reservoirs, viral host and genetic factors, aging related comorbidities, and signaling pathways in addictive substances that modify CNS outcomes. Research generated under this contract may also help with discoveries of novel pre-clinical therapeutic strategies for mitigating CNS complications associated with HIV.

PI_NAMEs: SHERMAN, SETH  (contact)

PROJECT_TERMS: Address;Adherence;aging related;Autopsy;Bioinformatics;Biological Markers;Biometry;Blood;Brain;Catalogs;central database;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Clinical;Clinical Data;clinical research site;cohort;Communities;comorbidity;Contracts;Data;Data Collection;Data Coordinating Center;data management;data repository;Databases;Disease;Disease Outcome;Ensure;Epidemiology;Evaluation;Funding;Genetic;Heart;HIV;HIV Seronegativity;HIV Seropositivity;HIV-1;Kidney;Knowledge;Laboratories;Liquid substance;Liver;Lung;Monitor;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;neuroAIDS;neurobehavioral;neuroimaging;Neuropsychological Tests;novel;operation;Organ;Outcome;Pathologic;Patients;Peripheral;Peripheral Nervous System;pre-clinical;Protocols documentation;public health relevance;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Resource Sharing;sample collection;Sampling;Services;Signal Pathway;Site;sound;Specimen;Spinal Cord;Testing;Therapeutic;Tissues;Toxicology;Update;Viral;Viral reservoir;Work

PROJECT_TITLE: DATA COORDINATING CENTER TO PROVIDE SERVICES TO WORK COLLABORATIVELY WITH THE NATIONAL NEUROHIV TISSUE CONSORTIUM CLINICAL SITES TO PROVIDE MANAGEMENT AND DATABASE CAPABILITIES, SCIENTIFIC EXPERTISE,


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

PI_NAMEs: SIGMAN, CAROLINE  (contact)

PROJECT_TERMS: Division of Cancer Prevention;National Cancer Institute;Services

PROJECT_TITLE: REGULATORY SERVICES AND TECHNICAL SUPPORT TO THE DIVISION OF CANCER PREVENTION (DCP)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: HINCKLEY

ORG_NAME: ICON GOVERNMENT AND PUBLIC HEALTH SOLUTIONS, INC.

ORG_STATE: OH

PI_NAMEs: SPITZ, ROBERT  (contact)

PROJECT_TERMS: Antibiotic Resistance;clinical trial implementation;Clinical Trials;Clinical Trials Unit;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Drug Kinetics;early phase clinical trial;Intervention;Investigation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;New Agents;Phase I Clinical Trials;Prevention;Safety;Special Population;study population;Study Subject;Therapeutic;Tuberculosis

PROJECT_TITLE: Task C1D1: A Study to Evaluate the Pharmacokinetics and Safety of a Therapeutic for Antibiotic-Resistant Tuberculosis


ADMINISTERING_IC: HG

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TERMS: Address;Attention;Biomedical Research;Characteristics;Country;Data;data access;data ecosystem;data resource;Dependence;Ecosystem;Ensure;Equipment and supply inventories;Financial Support;frontier;Funding;Funding Agency;Human;Infrastructure;International;Leadership;meetings;National Human Genome Research Institute;Nature;operation;Policies;programs;Progress Reports;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Science;Structure;Time;Travel;United States National Institutes of Health;Update;Wages;Work;working group

PROJECT_TITLE: Human Frontier Science Program


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE Cytopathology plays a critical role in the assessment of fine needle aspiration biopsies (FNAB) of thyroid nodules that may harbor cancers. This expertise is a scarce resource in Low and Middle Income Countries (LMIC). This project will tailor an existing machine learning algorithm for use in LMIC, specifically Tanzania and Vietnam, in order to have a future protocol in which expert cytopathology can be immediately accessible using existing equipment and mobile devices. This will be done through implementation of a protocol to analyze FNAB using a machine learning algorithm.

PI_NAMEs: LEE, WALTER TSONG (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: Archives;Area;Asian;Biopsy Specimen;Cellular Phone;Cessation of life;Clinical;Clinical assessments;clinical care;clinical decision-making;Clinical Trials;cost;cost effective;Country;Cytopathology;Data;Diagnosis;digital;Disease;Early Diagnosis;Equipment;Financial cost;Fine needle aspiration biopsy;Funding;Future;Goals;handheld mobile device;Health;Human Resources;Image;Improve Access;improved;Incidence;Institution;interest;International;Iodine;Laboratories;low and middle-income countries;Machine Learning;machine learning algorithm;Malignant neoplasm of thyroid;Malignant Neoplasms;Methods;Microscope;multidisciplinary;Nodule;Operative Surgical Procedures;Outcome;Outcome Measure;Pathologist;Pathology;Patient Care;Patients;Phase;Play;Population;Preparation;Probability;Procedures;prospective;Protocols documentation;public health relevance;Reporting;Research;Resolution;Resource-limited setting;Resources;Risk;Risk Factors;Role;Sampling;Sensitivity and Specificity;Services;skills;Slide;Specimen;Stains;standard of care;Stress;System;Tanzania;Testing;Thyroid Gland;Thyroid Nodule;Time;Training;Triage;ultrasound;Unnecessary Surgery;Vietnam

PROJECT_TITLE: Adapting a machine learning algorithm to predict thyroid cytopathologyin LMIC


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: LEXINGTON

ORG_NAME: ACCURIUS THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE accurius is developing a novel inhalable, safe, and highly effective treatment for the more than 100,000 patients that develop metastatic Non-Small Cell Lung Cancer every year in the U.S. Currently, only approximately 7% of these patients are expected to live five years or longer. The successful development and launch of this new technology could significantly improve the survival prospects for this large patient population.

PI_NAMEs: SRIVATSAN, MALLIKARJUN  (contact)

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Address;Agreement;Animal Model;Animals;anti-tumor immune response;arm;Body Weight decreased;Breathing;cancer cell;Cancer Model;Cancer Patient;Cell Culture Techniques;Cells;Cessation of life;chemotherapy;Clinic;Clinical Research;Collaborations;Combination Drug Therapy;commercial application;commercialization;Data;Development;Diagnostic;Disseminated Malignant Neoplasm;Distant;Dose;Drug Targeting;effective therapy;Engineering;experimental study;Face;follow-up;Formulation;Goals;Human;Immune;immune activation;immune checkpoint blockers;Immune response;immune-related adverse events;Immunity;Immunologic Markers;Immunotherapy;improved;Influenza A virus;Infusion procedures;Injections;Injury;Intellectual Property;Intravenous;Joints;Lead;Licensing;Lung;Lung Neoplasms;Malignant neoplasm of lung;manufacture;manufacturing process;Marketing;Mediating;medical schools;Metastatic Neoplasm to the Lung;Metastatic to;mouse model;Mus;Nebulizer;Neoplasm Metastasis;new technology;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncology;Oncolytic viruses;Overdose;patient population;Patients;Persons;Phase;pre-clinical;preclinical efficacy;Primary Neoplasm;Process;Production;research clinical testing;response;Safety;Small Business Innovation Research Grant;success;Survival Rate;T cell infiltration;Testing;Therapeutic;Therapeutic Effect;Time;Toxic effect;Treatment Efficacy;tumor;United States;Up-Regulation

PROJECT_TITLE: Preclinical and IND enabling studies for treatment of advanced lung cancer and other cancers metastatic to lung by pulmonary delivery of engineered Influenza A Virus (eIAV)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a leading cause of disability and death among U.S. older adults and represents an enormous public health burden. Although CVD risk assessment is recommended as the foundation to primary prevention and guiding treatment decisions, the current tool for risk assessment performs poorly in older adults and among disadvantaged population groups. We propose to address these limitations by incorporating changes in risk factors over time and integrating social determinants of health to improve CVD risk-prediction and its translation to disease prevention in U.S. older adults.

PI_NAMEs: DUPRE, MATTHEW E. (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Accounting;Address;Adopted;Adult;Age;age related;age related changes;age related decline;Aging;American;American Heart Association;Atherosclerosis Risk in Communities;Behavioral;Blood Pressure;Blood Vessels;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Caring;Cessation of life;Cholesterol;Classification;Clinical;cohort;college;Communication;Communities;Data;design;Development;disability;Disease;Disease Outcome;disorder prevention;disorder risk;Disparity population;Education;Elderly;Event;evidence base;Exercise;follow-up;Foundations;Goals;Guidelines;Hazard Models;Health;Health and Retirement Study;human old age (65+);implementation study;improved;Individual;innovation;Intervention;Knowledge;Measures;Medical;Mental Depression;Methods;Mission;Modeling;Multi-Ethnic Study of Atherosclerosis;multiple datasets;offspring;older adult;Onset of illness;Patients;Performance;Persons;Physiological;Population;Population Group;Population Heterogeneity;predictive modeling;prevent;Preventive therapy;Primary Prevention;prospective;psychosocial;Public Health;Recommendation;Risk;Risk Assessment;Risk Factors;risk prediction;Risk Reduction;routine care;Sampling;Series;shared decision making;social determinants;social health determinants;Social support;socioeconomics;support tools;Time;tool;Translating;Translations;treatment strategy;United States;United States National Institutes of Health;Validation;Visualization

PROJECT_TITLE: Integrating Risk Trajectories and Social Determinants to Enhance Cardiovascular Risk Assessment in Older Adults

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DK

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetic Testing;Genetics;Precision Medicine;Prevention;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

PHR: Project narrative  In this work, we will develop and validate prognostic biomarkers for prediction of diabetic wound healing. The optimized biomarkers would allow the identification of individuals who are not likely to heal their ulcer when treated with the standard of care, for use in the personalization of treatment and/or the refinement of entry criteria for clinical trials of new treatments.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: JONES, TERESA L Z

PROJECT_TERMS: Area;Base Ratios;Biological Markers;Cells;Chronic;Clinical;clinical effect;Clinical Trials;cohort;collagen scaffold;Complex;cost;Death Rate;Debridement;Detection;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;Ensure;Foundations;Gene Expression;Gene Expression Profiling;Genes;Genetic Markers;Goals;healing;Human;immune activation;Impaired wound healing;Impairment;In Vitro;indexing;Individual;Inflammation;Inflammatory;limb amputation;Link;Lower Extremity;Measurement;Measures;meetings;Methods;non-healing wounds;patient variability;Patients;personalized medicine;Phase;Phase II Clinical Trials;predicting response;predictive marker;Process;prognostic;Prognostic Marker;prognostic value;Quality Control;Quantitative Reverse Transcriptase PCR;Reproducibility;Research;Resolution;responders and non-responders;response;RNA;ROC Curve;sample collection;Sampling;secondary analysis;Sensitivity and Specificity;Shipping;Specificity;standard of care;Standardization;Techniques;Time;Tissue Banks;Tissue Model;Tissue Sample;Ulcer;United States;Visit;Work;wound;wound care;wound healing

PROJECT_TITLE: Inflammation-related gene biomarkers in human diabetic foot ulcer healing


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: STOKES, BAMBRA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Clinical;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communicable Diseases;Contracts;Country;HIV;HIV Infections;HIV/AIDS;Laboratories;National Institute of Allergy and Infectious Disease;Pharmacologic Substance;Populations at Risk;programs;Protocols documentation;Readiness;Research Project Grants;Research Support;Services;Site;Site Visit;Training;Translations

PROJECT_TITLE: HIV and Other Infectious Diseases Clinical Research Support Services (CRSS)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Sleep Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) is a chronic and relapsing brain disease that is characterized by loss of control over opioid use, and affects over 2 million Americans causing one overdose death every 20 minutes. Further research is urgently needed to better understand the mechanisms that contribute to ongoing illicit opioid use. The Collaboration Linking Opioid Use Disorder and Sleep (“CLOUDS”) Study examines sleep and circadian mechanisms that may contribute to OUD and proposes to fulfill a critical step towards identifying novel treatments that may lead to improved outcomes for patients with OUD.

PI_NAMEs: BARRY, DECLAN T.;REDEKER, NANCY S;SCHEINOST, DUSTIN ;YAGGI, HENRY KLAR (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: actigraphy;addiction;adverse childhood events;Affect;Alcohols;American;Behavior Therapy;Biological;Biological Assay;biomedical imaging;Blood;Brain;Brain Diseases;Buprenorphine;Characteristics;Chronic;circadian;Circadian Rhythms;Clinical;cognitive function;Collaborations;Conflict (Psychology);connectome;contextual factors;Discipline of Nursing;Environmental Risk Factor;Esthetics;Evidence based treatment;executive function;experience;Family;Family Characteristics;FDA approved;Fingerprint;Functional Magnetic Resonance Imaging;Gonadal Steroid Hormones;Home;Human;illicit opioid;Impairment;improved;improved outcome;incentive salience;innovation;Interview;Life Stress;Light;Link;Measures;Mediating;Medicine;Melatonin;Methadone;Moods;multidisciplinary;Naltrexone;Nature;negative affect;Neighborhoods;neural;Neurocognitive;Nicotine;Noise;novel;observational cohort study;opioid treatment program;opioid use;opioid use disorder;overdose death;Pain;pain perception;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Periodicity;Persons;Pharmaceutical Preparations;pharmacologic;Polysomnography;poor sleep;Prevention;primary outcome;Protocols documentation;Psychiatry;psychological trauma;Psychology;psychosocial;racism;Relapse;Reporting;Research;Research Personnel;response;reward processing;Risk;Risk Factors;Safety;Series;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;sleep quality;Sleeplessness;social cohesion;Social support;Stimulant;Stress;Structure;substance use;Surveys;System;Testing;Treatment outcome;treatment response;Violence;Wrist

PROJECT_TITLE: The Collaboration Linking Opioid Use Disorder and Sleep ("CLOUDS") Study


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Chronic Pain;Contraception/Reproduction;Endometriosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Prevention;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Acceleration;Accounting;Address;Adolescent;Adult;advanced disease;Affect;African ancestry;aged;Analgesics;Anatomy;Area;Asian ancestry;Attention;Autoimmune Diseases;Award;Awareness;Benign;Cellular Phone;cervicovaginal;Chronic;chronic pelvic pain;Clinical;clinical care;commercialization;comorbidity;Computer software;cost;Data;debilitating pain;Decision Making;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic biomarker;Diagnostic Equipment;diagnostic technologies;diagnostic tool;digital health;Disease;Disease Progression;Disparity in diagnosis;Dyschezia;Dysmenorrhea;Dyspareunia;Dysuria;Early Diagnosis;economic cost;Endometriomas;endometriosis;Endometrium;Environment;Female;Functional disorder;Geographic Locations;Goals;Growth;Guidelines;Health Personnel;Health Professional;Health Technology;Healthcare;Histologic;hormone therapy;Image;imaging modality;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;in-vitro diagnostics;Infertility;Infiltration;Inflammatory;innovative technologies;Insurance Coverage;interest;Laboratories;Laparoscopic Surgical Procedures;Life;Location;Lupus;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Malignant Neoplasms;Marketing;Masks;Medical;Medical Care Team;medical specialties;Mental Depression;Migraine;Modality;Multiple Sclerosis;National Institute of Child Health and Human Development;Non-Malignant;noninvasive diagnosis;novel diagnostics;novel strategies;Operative Surgical Procedures;Pain;Participant;Pathogenesis;Patients;Perception;Peritoneal;Phase;point of care;Population;Predictive Value;Prevention;Prize;Process;Professional Organizations;Prognosis;Protocols documentation;prototype;Provider;Quality of life;Race;RADx Tech;Recovery;Recurrence;Reproducibility;reproductive;Research;research and development;Risk;Safety;Saliva;Sampling;screening;Screening procedure;sensor technology;Serum;Severities;sex disparity;side effect;Socioeconomic Status;socioeconomics;Source;Specialist;Staging;surgical risk;symptomatology;Symptoms;Techniques;Technology;technology development;Testing;Time;Tissues;Training;Transvaginal Ultrasound;Underrepresented Populations;Underserved Population;Uterus;virtual;Visualization;wearable device;Woman

PROJECT_TITLE: NICHD RADX TECH ACT ENDO CHALLENGE AWARD - INITIAL OBLIGATION


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Dysregulated mucosal trafficking and activation of neutrophils in the intestine are major factors contributing to pathobiology of inflammatory bowel disease (IBD). The goal of this application is to determine how neutrophil CD45 can be selectively targeted to down regulate excessive neutrophil migration and effector functions during intestinal inflammation. Results from these studies will provide ideas for new targeted therapies to reduce pathological inflammation and improve quality of life for individuals with IBD and other mucosal inflammatory disorders.

PI_NAMEs: BRAZIL, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Abscess;Antibodies;Apoptosis;Binding;Binding Proteins;Cells;Chronic;Clinical;Colitis;Colon Injury;Complex;crypt cell;Data;Disease;Edema;Epithelium;Event;extracellular;functional outcomes;glycosylation;Goals;Goblet Cells;gut inflammation;Host Defense;Human;Hyperplasia;improved;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;injury and repair;Integrins;intestinal epithelium;Intestines;ITGAM gene;ITGB2 gene;Knock-out;Knockout Mice;Lectin;Ligands;Ligation;Link;Mediating;migration;Molecular;Molecular Conformation;Mucositis;Mucous body substance;Mucous Membrane;Mus;neutrophil;Neutrophil Activation;new therapeutic target;novel;novel strategies;Pathogenesis;Pathologic;Pathology;Phagocytosis;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Polysaccharides;Production;Protein Isoforms;Protein Tyrosine Phosphatase;PTPRC gene;Quality of life;Regulation;repaired;RNA Splicing;Role;S100A8 gene;Signal Pathway;Signal Transduction;src-Family Kinases;Structure;Superoxides;Therapeutic;tissue repair;Tissues;trafficking;Ulcer;Variant

PROJECT_TITLE: CD45 mediated regulation of PMN function during intestinal inflammation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Immunotherapy

ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This project will enhance our capability to invent therapeutics and subsequently prepare these medicines on large-scale. Inspired by Nature’s catalyst, we develop ideal, environmentally friendly, and powerful ways to transform simple building blocks (aldehydes, alkenes, and alkynes) into architectures relevant to medicine. Our expertise in molecular design and synthesis will also be applied to address challenges at the interface of chemical theory, fluorescent microscopy, and drug discovery.

PI_NAMEs: DONG, VY M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Aldehydes;Alkenes;Alkynes;Amines;Architecture;Biology;cancer immunotherapy;Carbon;Catalysis;catalyst;chemical synthesis;Chemicals;Cobalt;Copper;Coupling;cyclopropene;design;design and construction;diene;drug discovery;Environment;experimental study;Friends;functional group;innovation;insight;invention;Medicine;Metals;Methods;Microscopy;Modernization;Molecular;Molecular Probes;Nature;Nitrogen;NMR Spectroscopy;Organic Synthesis;Periodicity;Pharmaceutical Chemistry;Research Project Summaries;Rhodium;Science;Styrenes;Theoretical Studies;theories;Therapeutic;tool;Training;Transition Elements;unsaturated bonds

PROJECT_TITLE: Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The proposed “Sjögren’s Team for Accelerating Medicines Partnership (STAMP)” is strategically positioned to apply cutting-edge technologies to interrogate the tissue and systems biology of Sjögren’s disease (SjD) to better understand 1) the pathogenesis of SjD and identify therapeutic targets, and new biomarkers; and 2) disease mechanisms inherent to progression of SjD from non-SjD to SjD, and from “early SjD” to “advanced SjD”. To achieve these goals, we plan to develop a 5-year scientific research agenda, and design standardized clinical research protocols to recruit, enroll, phenotype, and collect relevant biospecimens from, observational cohorts of individuals with SjD and controls.

PI_NAMEs: BAER, ALAN N;FARRIS, A DARISE;SHIBOSKI, CAROLINE HELENE (contact);WARNER, BLAKE MATTHEW

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Address;Adopted;Advisory Committees;Affect;American;Arthralgia;Atlases;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Award;Biological;Biological Markers;Calibration;California;cell type;Cells;Classification;Clinic;Clinical;Clinical assessments;Clinical Data;Clinical Research;Clinical Research Protocols;Clinical Trials;cohort;Collaborations;college;Data;deep sequencing;Derivation procedure;design;Diagnosis;Disease;DNA Methylation;Early Diagnosis;effective therapy;Enrollment;Epidemiology;European;Exocrine Glands;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;eye dryness;Fatigue;follow-up;Foundations;Functional disorder;Funding;Future;Genetic;genetic association;Genetic Heterogeneity;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Heterogeneity;high risk;Immune;improved;Individual;Inflammation;International;Lacrimal gland structure;Lymphocytic Infiltrate;Lymphoma;Mediating;Medical Research;Medicine;Molecular;Molecular Analysis;Molecular Biology;Morbidity - disease rate;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Dental and Craniofacial Research;Natural History;Nature;New York;Nuclear;Oklahoma;Oral;Participant;Pathogenesis;Pathway interactions;Patient Care;Patient Recruitments;Patients;Phase;Phenotype;Positioning Attribute;pre-clinical;Prevalence;Protocols documentation;Quality of life;reconstruction;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;risk variant;Salivary Gland Tissue;Salivary Glands;Sampling;San Francisco;scale up;Scientist;single cell mRNA sequencing;single-cell RNA sequencing;Site;Sjogren's Syndrome;Standardization;symptom management;Syndrome;System;systemic autoimmune disease;Systems Biology;Technology;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;Translating;Universities;Validation;whole genome;Work


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Human Genome;Pediatric;Prevention;Rheumatoid Arthritis

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative This project aims to understand how genetic factors increase the risk for juvenile idiopathic arthritis (JIA), one of the most common chronic disease conditions in children. In this study, we will examine how genetic variants alter a class of genome regulators called enhancers, which are like rheostats that allow cells to turn genes up or down depending on the circumstances. We will then identify genes that are affected by altered enhancers, an important step toward developing new therapies and improving outcome for children with this disease.

PI_NAMEs: JARVIS, JAMES N (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Allelic Imbalance;ATAC-seq;Autoimmune Diseases;Bioinformatics;Biological;Biological Assay;Blood Cells;causal variant;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Child;Childhood;ChIP-seq;Chromatin;chromatin modification;Chromatin Structure;Chronic Childhood Arthritis;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;Clinical;Complex;Data;Disease;disease phenotype;disorder risk;DNA;DNA Resequencing;Elements;Enhancers;Epigenetic Process;epigenome;Frequencies;Gene Expression;gene interaction;Genes;Genetic;genetic association;Genetic Diseases;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;Genotype;genotyped patients;Haplotypes;Histones;improved outcome;in silico;In Vitro;Influentials;innovation;insight;Investigation;Knowledge;Laboratories;Link;Linkage Disequilibrium;Lupus;Maps;Methods;novel therapeutics;Pathologic;Patients;permissiveness;Phenotype;Process;promoter;Property;Publishing;Quantitative Trait Loci;Reporter;Reporter Genes;Research Personnel;Rheumatism;Risk;risk variant;Role;Signal Transduction;Testing;therapy outcome;tool;trait;Transactivation;transcriptome sequencing;Untranslated RNA;Variant

PROJECT_TITLE: Epigenetic Mechanisms That Drive Genetic Risk in Juvenile Arthritis

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE The Integrated Networks of Scholars in Global Health Research Training (INSIGHT) consortium formed between the University of Alabama at Birmingham, the Baylor College of Medicine, the University of Maryland Baltimore, and the University of Pittsburgh supports training for the next generation of global health scholars from the US and low- and middle-income countries (LMICs) through mentored research experiences at 24 established partner LMIC institutions across 19 countries in Africa, Asia, and Latin America and the Caribbean. Strong emphases are on a broad range of global health research areas, including combatting the global HIV epidemic and associated co-morbidities, emerging and re-emerging infectious diseases, non-communicable diseases, and mental health.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);MANDALAKAS, ANNA M;NIMGAONKAR, VISHWAJIT LAXMIKANT;TURAN, JANET M.

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Africa South of the Sahara;Applications Grants;Asia;Behavioral;career;Caribbean region;Clinical;cohort;Collaborations;Disease;Emerging Communicable Diseases;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Faculty;Foundations;Generations;global health;HIV;innovation;Institution;interdisciplinary collaboration;Laboratories;Latin America;Link;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Minority-Serving Institution;Monitor;multidisciplinary;Outcome;outreach;Postdoctoral Fellow;pre-doctoral;Process;Program Evaluation;programs;Publishing;Research;Research Personnel;Research Training;Role;Schools;Science;Shapes;Strategic Planning;student participation;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Universities;Vision;Woman;Work


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Revised Project Narrative This work may identify the genetic basis for the predisposition to acquire myeloproliferative neoplasm as well as develop a screening tool to identify those with this predisposition. This population at risk could then be targeted for preventative studies.

PI_NAMEs: FLEISCHMAN, ANGELA GOFFREDO (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Acetylcysteine;Affect;Age;aged;Aging;aging population;Agonist;Anti-Inflammatory Agents;Antioxidants;Attention;biobank;Biological Markers;Blood;Bone Marrow;Bone Marrow Stem Cell;Cell Cycle;cell type;Cells;ChIP-seq;Chronic;Clinical Trials;Clonal Hematopoietic Stem Cell;cytokine;Cytokine Receptors;Cytotoxic Chemotherapy;Data;Development;DNA Methylation;DNA sequencing;DNMT3a;Endowment;exhaustion;experimental study;Exposure to;Family;Family history of;Family member;Family-Based Registry;fitness;Gene Expression;Gene Expression Profiling;Genes;Genetic;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell quiescence;Hematopoietic stem cells;Human;Inflammation;Inflammatory;Interleukin-10;Ligands;Link;Lipopolysaccharides;Malignant - descriptor;member;Methylation;methylation pattern;Modeling;monocyte;mosaic;Mus;mutant;Mutation;Myeloproliferative disease;Oxidative Stress;Pathway interactions;Patients;peripheral blood;Persons;pharmacologic;Phenotype;Populations at Risk;Predictive Value;Predisposition;preservation;Prevalence;prevent;Prevention trial;Production;progenitor;Proliferating;Reactive Oxygen Species;Recombinant Interleukin-10;Recording of previous events;Regulation;Resistance;response;Role;Screening procedure;Signal Transduction;Sorting;stem;stem cell exhaustion;stem cell function;Stress;stressor;Testing;Therapeutic;TLR4 gene;TNF gene;Toll-like receptors;transcriptome sequencing;Translating;Transplantation;Wild Type Mouse;Work

PROJECT_TITLE: Role of IL-10R signaling in inflammation induced exhaustion of HSC and emergence of JAK2V617F clonal hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE SUMMARY (Parent)  The Overarching Aim of the Northwestern HeartShare Data Translation Center (DTC) is to provide overall management and oversight for HeartShare, including coordination and communication across all subsections and cores of the program, and with the 4 HeartShare Clinical Centers (CCs). The DTC will need to ensure timely completion of the retrospective (first 2 years) and prospective (all 5 years) components of HeartShare. In our application, we demonstrate the ability and prior experience of our multi-PI team and core leaders in the conduct and leadership of large-scale, multi-center studies, particularly in the realms of HFpEF, EHR-based investigation, deep phenotyping, and biorepositories. We also highlight our experience as liaisons/translators among clinical researchers, clinicians, and data scientists; expertise in phenotype ontology and harmonization; and collaboration with the University of Vermont biorepository, which has extensive experience in this realm. For both the retrospective and prospective HeartShare components, the Northwestern DTC will leverage its considerable experience in: (1) cohorts and trials that have data on adjudicated HFpEF patients, and (2) its leadership and track record as the top enroller in HFpEF trials/studies to ensure optimal recruitment by the HeartShare CCs. We will also leverage our expertise in HFpEF, data coordination/management, BioData Catalyst, electronic health record-based research, biostatistics, data science, machine learning, multi-omics, human-computer interaction, and mobile health data monitoring to successfully execute the HeartShare program and meet The HeartShare DTC goals of providing a rich resource to the research community and advancing the science of next-generation phenomics to identify HFpEF subtypes and therapeutic targets. Our HeartShare DTC will carry out each of its 4 primary responsibilities. (1) The Administrative and Outreach Core will oversee HeartShare program operations, research skills development, and capitation to CCs for deep phenotyping costs; support a call center to follow patient outcomes; and promote rapid and broad data-sharing of clinical and molecular data. (2) The Data Portal Core will serve as the primary access point (via a web-based interface) and coordinating center for all HeartShare data; and to develop an interactive patient-facing web-based interface for remote consent, completion of forms, and collection of mobile health data using BioData Catalyst tools. (3) The Data Management Core will oversee and perform data quality, integration and harmonization of various data types; performance of advanced analytics; coordination of biospecimen and imaging biorepositories; and integration with TOPMed for omics analyses. (4) The Cohort Core will aggregate data on HF patients from completed epidemiology cohorts and HF trials and will combine data with further bioprofiling of existing samples to allow discovery/validation of novel targets. PROJECT NARRATIVE  The Northwestern HeartShare Data Translation Center will provide overall management and oversight of the HeartShare program via 4 cores, including an Administrative/Outreach, Data Portal, Data Management, and Cohort cores. By providing a diverse investigative team and complementary areas of expertise, the HeartShare Data Translation Center will achieve the primary goals of HeartShare: (1) to develop a rich resource for the research community for the detailed study of heart failure; and (2) to advance the science of identifying novel heart failure subtypes to promote a tailored, precision medicine approach to heart failure patients in order to reduce morbidity and mortality.

PI_NAMEs: KHO, ABEL N.;LUO, YUAN ;SCHOLTENS, DENISE M;SHAH, SANJIV J (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: adjudication;Adopted;advanced analytics;Advocacy;Algorithms;Area;Awareness;biobank;Biometry;Blood Pressure;Cardiology;catalyst;Cessation of life;Classification;Clinic;Clinical;clinical center;cohort;Collaborations;Collection;Communication;Communities;comorbidity;Complex;computer human interaction;Consensus;cost;Data;Data Aggregation;data cleaning;Data Collection;data interoperability;data management;data modeling;data portal;data quality;Data Science;Data Scientist;Data Set;Databases;demographics;Deposition;deprivation;Diagnostic tests;Disease;Echocardiography;effective therapy;EFRAC;EHR research;Electronic Health Record;Elements;Enrollment;Ensure;Epidemiology;Equipment and supply inventories;evidence base;experience;Fast Healthcare Interoperability Resources;Force of Gravity;Funding;Future;Generations;Goals;Health;health data;health equity;Health system;Healthcare;Heart failure;heart failure with reduced ejection fraction;Hospitalization;Image;Incentives;indexing;Individual;instrument;Integrated Health Care Systems;interest;interoperability;Investigation;Leadership;Machine Learning;Maps;Measurement;Mediator;Medical;Medicine;Methods;mHealth;Molecular;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;multiple omics;National Heart, Lung, and Blood Institute;Natural Language Processing;next generation;novel;Observational Study;Ontology;open source;operation;Outcome;outreach;Parents;Participant;patient population;Patient-Focused Outcomes;Patients;Patterns of Care;Performance;Persons;Pharmaceutical Preparations;phenomics;Phenotype;PhenX Toolkit;Population Heterogeneity;precision medicine;Preparation;preservation;Primary Care;Procedures;Process;programs;prospective;recruit;Registries;remote consent;repository;Research;Research Personnel;Resources;Retrospective cohort;Risk;Risk Factors;Role;Sampling;Science;Site;skill acquisition;social;social health determinants;Social Work;Structure;Surveys;Survival Rate;Syndrome;Therapeutic;therapeutic target;tool;Touch sensation;Trans-Omics for Precision Medicine;Translations;United States National Institutes of Health;Universities;Validation;Vendor;Vermont;web based interface;Work;working group

PROJECT_TITLE: HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Diabetes;Dietary Supplements;Estrogen;Infertility;Nutrition;Obesity;Polycystic Ovary Syndrome (PCOS);Prevention;Women's Health Research

ORG_CITY: HERSHEY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women in the U.S. and is characterized by both reproductive (anovulation and androgen excess) and metabolic dysfunction (insulin resistance). PCOS lacks a simple, safe and effective treatment for women of all ages and all weights. Recently a dietary supplement, inositol, has been used widely to treat women with PCOS. However there are no well- designed trials to address the risk/benefit ratio and identify the mechanism of action. In this study we are actively conducting a three month double blind (of both patients and investigators) randomized controlled trial of inositol supplementation compared to placebo. Our primary outcome is, women with PCOS who receive inositol supplementation will have a significantly greater reduction in serum total testosterone than women on placebo.

PI_NAMEs: LEGRO, RICHARD S. (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Address;Adolescent;Advocate;Affect;Age;androgen excess;Androgens;Anovulation;Area Under Curve;Body Weight decreased;Cell surface;Chronic;chronic anovulation;Clinical Trials Design;clinically relevant;Clomiphene;Consensus;Contraceptive Usage;Data;design;Deterioration;dietary supplements;Dose;Double-Blind Method;effective therapy;Endocrine;Enrollment;experience;Fasting;Female;Functional disorder;Glucose;Glucose Intolerance;glucose tolerance;Glucose tolerance test;Goals;Gonadotropins;Guidelines;Health;Hyperandrogenism;improved;indexing;Infertility;infertility treatment;innovation;Inositol;Insulin;Insulin Resistance;insulin sensitizing drugs;insulin signaling;Isomerism;Letrozole;life span;Life Style Modification;Menopause;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metformin;multidisciplinary;myoinositol;Obesity;Oral;Oral Contraceptives;Overweight;Ovulation Induction;Patients;Pharmaceutical Preparations;Phase;Placebos;Polycystic Ovary Syndrome;Population;primary outcome;Probability;prospective test;randomized, clinical trials;Randomized, Controlled Trials;reproductive;Research Personnel;risk/benefit ratio;Role;Second Messenger Systems;secondary outcome;Serum;Sex Hormone-Binding Globulin;Signal Transduction;Stereoisomer;Supplementation;Syndrome;Testing;Testosterone;Thiazolidinediones;trial design;Weight;Woman;women's treatment

PROJECT_TITLE: Inositol Supplementation to Treat Reproductive and Metabolic Dysfunction in Polycystic Ovary Syndrome: A Double Blind RCT (INSUPP-PCOS)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health;Pediatric;Violence Research;Youth Violence

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The overall objective of the proposed project is to study the biological basis of violent juvenile aggression in a novel animal model. This work has implications for public health as experiences of aggression have long-lasting individual and societal consequences and disorders with high co-morbidity of aggressive behavior are on the rise, but a tractable model system is currently lacking. Research outcomes will have a significant positive impact by illuminating causes, consequences, and potential treatments targets for violent aggression among the youngest members of our society.

PI_NAMEs: FISCHER, EVA K (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Genomic mechanisms of violent juvenile aggression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Down Syndrome;Immunization;Intellectual and Developmental Disabilities (IDD);Vaccine Related

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it interrogates mechanisms of CD4+ T cell dysregulation and of impaired vaccine response in people with Down syndrome. This knowledge would establish the foundation to identify therapies to mitigate immune aging and impaired vaccine response in people, both with and without Down syndrome, with likely utility across a broad spectrum of immune-related conditions. Thus, the proposed research is relevant to the part of NIH's mission pertaining to reducing illness and disability.

PI_NAMEs: KHOR, BERNARD  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Administrative Supplement;Aging;antigen-specific T cells;Antigens;Autoimmunity;B-Lymphocytes;Basic Science;biobank;CD4 Positive T Lymphocytes;Cells;Clinical Data;cohort;Collaborations;Communities;Computer Analysis;computerized tools;cooking;COVID-19 vaccination;Data;Data Collection;data curation;data hub;disability;Dissection;DNA;Down's Syndrome;experimental study;Foundations;Goals;high reward;high risk;Immune;immune function;Immune response;Impairment;improved;Individual;Inflammaging;interest;Interleukin-6;Investments;Knowledge;Letters;life span;Link;Memory;Mission;mosaic;multiple omics;Nature;parent grant;Participant;Persons;phenomics;Phenotype;phenotypic data;Postdoctoral Fellow;Proteins;Public Health;Publishing;recruit;Research;Resources;response;Sampling;success;T-Lymphocyte;tool;United States National Institutes of Health;vaccine evaluation;vaccine response;Vaccines;Work

PROJECT_TITLE: Dissecting T and B cell dysregulation in people with Down syndrome


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy

PHR: Project Narrative  Immune, malignant, vascular, and other cells present in tumors are not randomly distributed, but are organized into different neighborhoods typified by specific, recurrent sets of multicellular interactions. This research proposal explores how a recently discovered, clinically significant multicellular network shapes the behavior of cancer-fighting T cells. By understanding and manipulating this cellular neighborhood, we may be able to mold T cells to optimally combat cancer.

PI_NAMEs: CHEN, JONATHAN HOWARD (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Academia;Advisory Committees;anti-tumor immune response;Antigens;Antitumor Response;Area;B-Lymphocytes;Behavior;Biological;Biological Assay;Biology;Blood Vessels;cancer cell;Cancer Patient;cancer therapy;career development;CD8-Positive T-Lymphocytes;cell behavior;Cell Communication;cell type;Cells;chemokine;Chronic;clinically significant;Colorectal Cancer;combat;Communication;CXCL10 gene;CXCL11 gene;CXCL13 gene;Data;Data Set;Development Plans;Environment;Environmental Risk Factor;exhaust;exhaustion;Faculty;Feedback;fighting;General Hospitals;Genes;Grant;Human;human DNA;Hybrids;Hypoxia;Immune;Immunity;Immunotherapy;improved;In Situ Hybridization;in vitro testing;instructor;Interferon Type II;Interferons;Investigation;Laboratories;Leadership;Ligands;lymph nodes;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Massachusetts;Mentors;Mentorship;Microscopy;Mismatch Repair;Mismatch Repair Deficiency;Molds;Morphology;Neighborhoods;Pathologist;Pathology;Pathway interactions;Patients;PD-1 blockade;Phenotype;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;Process;Professional Competence;programs;Recording of previous events;recruit;Recurrence;Research;Research Proposals;response;RNA;Role;Sampling;Scientist;Series;Shapes;single-cell RNA sequencing;skills;Specimen;stem;Structure;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technical Expertise;Therapeutic;Tissues;Training;transcriptomics;translational potential;tumor;Tumor Immunity;tumor immunology;Writing

PROJECT_TITLE: Delineating the mechanisms by which tumor immunity multicellular networks shape T cell state

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Depression is prevalent, debilitating, and costly, and maternal depression is one of the most established risk factors of depression in offspring; however, the genetic and environmental risk factors tied to intergenerational risk are complex and largely unspecified. I will conduct a multimodal, dyadic research design to examine a potential neurobehavioral pathway from depression in mothers to the development of increased depression risk in young children. This study has relevance for identifying children at greatest risk for depression development according to neural indicators and proposing a behavioral target for intervention in mother−child processes in order to mitigate risk.

PI_NAMEs: HILL, KAYLIN ESTELL (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Neurobehavioral markers of positive valence systems in mothers with depression and young offspring

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Relevance to Public Health Meiosis is a specialized set of cell divisions that generate male (sperm) and female (egg) gametes. In females, meiosis is associated with high rates of chromosome segregation errors, which lead to miscarriage, infertility, and developmental disorders such as Down’s syndrome. This project uses mouse oocytes as a model system to understand the basic molecular mechanisms that regulate female meiosis, thereby shedding a light on why this process is notoriously error prone.

PI_NAMEs: BALBOULA, AHMED  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms underpinning meiotic spindle formation and behavior


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The UCLA-South Africa Sustainable Academic Capacity Building for Excellence in Research Training (SACERT) builds on 14 years of research training of South African early career investigators and academic communities on chronic stress and non-communicable chronic mental health disorders including substance abuse, depression, and posttraumatic stress disorder across the life course. As an international collaboration between UCLA and 12 institutions in South Africa, including University of Cape Town, Human Sciences Research Council, Stellenbosch University, and Walter Sisulu University, SACERT’s public health mission is to: 1) increase the number of well-trained South African researchers and mentors in chronic stress and non- communicable chronic mental health; 2) translate research findings into culturally congruent substance abuse and mental health treatment interventions and programs; and 3) facilitate the building of sustainable community clinical and research capacity and university infrastructure that benefits South African people.

PI_NAMEs: HAMILTON, ALISON B.;KLEINTJES, SHARON ROSE;SIMBAYI, LEICKNESS ;WYATT, GAIL E. (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Applications Grants;Area;Chronic;Chronic stress;Climate;Disadvantaged;Discipline of Nursing;Doctor's Degree;doctoral student;Education;Educational workshop;Environment;experience;Faculty;Goals;improved;Institution;Knowledge;Leadership;Learning;Life Cycle Stages;Master of Science;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;multidisciplinary;Occupational Therapy;Pathway interactions;Persons;Post-Traumatic Stress Disorders;pre-doctoral;Principal Investigator;Productivity;Psychiatry;Psychology;Public Health;Publications;Research;Research Training;residence;response;satisfaction;skills;Social Work;South Africa;South African;Substance abuse problem;Time;Training;Training Programs;Universities;virtual

PROJECT_TITLE: Refining and Expanding the SACERT-Learning Collaborative and Integrated Measures Bank-South Africa


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PI_NAMEs: BRITTON, WARWICK  (contact)

PROJECT_TERMS: Adjuvant;Aerosols;Animals;Antigens;Cause of Death;Cells;clinical candidate;clinical development;Development;Disease;Dose;Evaluation;Formulation;Goals;HIV;Human;Immune;Immunity;Immunologics;In Vitro;Inbred Mouse;Infectious Agent;Macaca mulatta;Modeling;mouse model;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nonhuman primate;novel;Persons;Preventive;programs;Research;Research Personnel;Risk;Side;Treatment outcome;Tuberculosis;tuberculosis treatment;Tuberculosis Vaccines;Vaccine Adjuvant;Vaccines;Work

PROJECT_TITLE: ADVANCING VACCINE ADJUVANT RESEARCH FOR TUBERCULOSIS (AVAR-T)


NIH_SPENDING_CATS: Cancer

ORG_CITY: ALACHUA

ORG_NAME: ALCHEM LABORATORIES CORPORATION

ORG_STATE: FL

PI_NAMEs: TALTON, JAMES  (contact)

PROJECT_TERMS: Benzamides;cancer therapy;clinical development;Contractor;Developmental Therapeutics Program;Dioxanes;drug synthesis;Drug Utilization;Human;Pharmaceutical Preparations;Sampling;Therapeutic Agents

PROJECT_TITLE: SYNTHESIS OF UP TO TEN SAMPLE COMPOUNDS PER YEAR (Option Yr 3)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: TAKOMA PARK

ORG_NAME: GRYPHON SCIENTIFIC, LLC

PI_NAMEs: SUMNER, LOUISE  (contact)

PROJECT_TERMS: analytical tool;Biological;Chemical Structure;Chemicals;Contracts;Data;drug development;Evaluation;Formulation;Hepatitis B Virus;HIV;HIV therapy;Program Development;repository;Research;Structure;Structure-Activity Relationship;Surveys;Therapeutic;Tuberculosis;web site;Work

PROJECT_TITLE: Analysis of Chemical Structures and Therapeutic Activity of Agents for HIV, TB, and HBV (CHEMDB)


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: MARINO, MARK  (contact)

PROJECT_TERMS: Biological Assay;commercialization;Evaluation;Research;Screening for cancer

PROJECT_TITLE: NCE FOR COMMERCIALIZATION CENTER TASK ORDER FOR CANCER SCREENING RESEARCH NETWORK


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE The prevalence of gestational diabetes mellitus (GDM) has increased substantially, and it is associated with both short- and long-term adverse outcomes for both women and their children. The strategies used for GDM rely on diagnosis and treatment in the third trimester, but these have not consistently reduced or eliminated the adverse outcomes that occur. Therefore, there is a vital need to develop novel strategies, including earlier diagnosis and better ascertainment of blood sugar profiles, that predict adverse outcomes related to dysglycemia, which will result in better treatment approaches and outcomes.

PI_NAMEs: LOWE, WILLIAM L;YEE, LYNN M (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Admission activity;advanced analytics;Adverse effects;adverse maternal outcomes;adverse outcome;adverse pregnancy outcome;Birth;Birth trauma;Blood Glucose;Cardiovascular Diseases;Cesarean section;Child;Childhood;Clinical;Clinical Trials;clinically relevant;Continuous Glucose Monitor;Data;Data Analyses;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Dystocia;Early Diagnosis;early pregnancy;Evaluation;Evolution;experience;fasting glucose;First Pregnancy Trimester;Frequencies;Future;Gestational Age;Gestational Diabetes;Glucose;glucose monitor;Health;high risk;Hour;Hyperglycemia;Hypertension;Hypoglycemia;insight;Intervention;Low Birth Weight Infant;maternal hyperglycemia;maternal outcome;Measures;Metabolic;Metabolic Diseases;Natural History;Neonatal;Neonatal Hypoglycemia;Neonatal Intensive Care Units;neonatal outcome;newborn adiposity;Newborn Infant;novel strategies;Obesity;OGTT;Outcome;Outcome Study;Pattern;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;Prevalence;Randomized;Risk;Shoulder;success;Suggestion;therapy design;Third Pregnancy Trimester;Time;Woman;Women's cohort;women's diagnosis

PROJECT_TITLE: Glycemic Profiles and Pregnancy Outcomes Study (GLOSS)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: NEW YORK

ORG_STATE: NY

PI_NAMEs: LEE, WALT  (contact)

PROJECT_TERMS: Area;Cancer Therapy Evaluation Program;Clinical Trials Support Unit;Computer software;Contractor;Contracts;Data;Databases;Development;Ensure;Funding;Future;Maintenance;Medidata;Monitoring Clinical Trials;Parents;Production;programs;Services;Standardization;Support System;Systems Integration;Testing;Time

PROJECT_TITLE: HOSTING, MAINTENANCE AND PROFESSIONAL SERVICES FOR RAVE AND MEDIDATA RAVE INTEGRATED ANCILLARY SOFTWARE FOR NCI'S CANCER THERAPY EVALUATION PROGRAM (CTEP)


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: DESSAU-ROSSLAU

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: IDT BIOLOGIKA GMBH

PI_NAMEs: SINGH, SUNEEL  (contact)

PROJECT_TERMS: Adjuvant;Biological Products;Clinical Research;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;Human;influenza virus vaccine;influenzavirus;manufacture;novel vaccines;Phase;product development;research clinical testing;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V32: Manufacture of Influenza Virus Human Challenge Material for Phase I/II Clinical Testing


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Wound Healing and Care

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE At Stanford over the last decade, the Gurtner group has used NIDDK funding to identify the best treatment plans to improve blood flow, decrease blood glucose, and enhance the body's ability to heal wounds and prevent amputations. With Dr. Gurtner recently assuming the position of Chair of Surgery at the University of Arizona (UArizona) College of Medicine-Tucson, the entire team has moved and worked tirelessly to seamlessly transfer all the existing Diabetic Foot Consortium (DFC) studies to UArizona. In this proposal, we will continue these important studies at UArizona to collect a large range of samples from a diverse patient population to improve biomarker identification and standard of care efforts for DFUs, as well as demonstrate our potential for the addition of various satellite sites throughout the Southwest.

PI_NAMEs: GURTNER, GEOFFREY C (contact);ZHOU, WEI

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: academic program;Acceleration;Address;Adherence;Adult;Affect;American;American Indian Population;American Indians;Amputation;Ancillary Study;Arizona;bench to bedside;Bioinformatics;Biological Markers;biomarker identification;biomarker validation;Blood flow;Blood Glucose;Blood Vessels;Caring;Cells;Chairperson;chronic wound;Clinical;clinical care;clinical center;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Collection;college;Communities;Community Actions;comorbidity;Complex;contextual factors;Data;Debridement;Dedications;demographics;design;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;drug candidate;Education;Educational Status;Environment;Ethnic Origin;experience;FDA approved;Foundations;Funding;Grant;healing;Health;Heterogeneity;higher education;Hispanic;Hispanic Populations;Human;improved;Individual;Infrastructure;innovation;Institution;interdisciplinary approach;International;Intervention;Latino;limb amputation;Limb Salvage;Lower Extremity;Medical;Medicine;Minority;Mission;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;open wound;Operative Surgical Procedures;outcome prediction;outreach;outreach program;Pathologic;Pathology;Patient Care;Patient Compliance;patient population;Patient Recruitments;Patients;Persons;Physicians;Podiatry;Population;Positioning Attribute;predictive marker;Prevalence;prevent;Problem Solving;programs;provider adherence;Publications;Recommendation;Recording of previous events;recruit;Recurrence;Reporting;Research;Resource Sharing;Role;Sampling;Services;single-cell RNA sequencing;Site;social;social deprivation;social factors;social health determinants;Socioeconomic Status;Source;standard of care;Surgeon;Techniques;Testing;Tissues;Trauma;treatment planning;United States;United States Indian Health Service;United States National Institutes of Health;Universities;Work;wound;wound care;wound healing

PROJECT_TITLE: The University of Arizona Wound Care Center Clinical Research Unit


NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Digestive Diseases;Gene Therapy;Genetics;Hematology;Liver Disease;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE There are many patients of a-thalassemia, current therapies are insufficient for many of them and there are very few studies on a-thalassemia; in addition, no severe mouse models are available to study this disease and to test new therapies. Our goals are to generate new mouse models to investigate this understudied disease and to test if a newly generated lentiviral vector that expresses the human a-globin gene can correct mice affected by severe forms of a-thalassemia. Our proposed work will address these knowledge gaps by developing, characterizing, and validating mouse models and gene therapy vectors for treating severe a-thalassemia.

PI_NAMEs: RIVELLA, STEFANO  (contact)

PROJECT_TERMS: Adult;Adverse effects;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;alpha Globin;alpha-Thalassemia;Anemia;Animals;Area;beta Globin;beta Thalassemia;Blood Transfusion;Cell Line;Cells;Cessation of life;Clinical;Clinical assessments;Coagulation Process;curative treatments;Deposition;design;Development;Disease;disease phenotype;Emigrations;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Erythropoietin;ethnic minority;Event;experience;expression vector;Failure to Thrive;Fetal Liver;Functional disorder;Gene Deletion;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;genome editing;Geographic Locations;Goals;Graft Rejection;graft vs host disease;Hematocrit procedure;Hematology;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin concentration result;Hemoglobinopathies;Hepatosplenomegaly;hepcidin;Human;Hypoxemia;improved;Individual;Inherited;insight;interest;Iron;iron metabolism;Iron Overload;Kidney;Knock-out;Knowledge;Lentivirus Vector;Life;life span;Liver;Locus Control Region;mature animal;Modeling;Modification;mouse model;Multiple Organ Failure;Mus;Mutation;novel;novel strategies;novel therapeutics;Organ;Oxygen;Pathology;Patients;Periodicals;Phenotype;prevent;Production;promoter;Proteins;Publishing;racial minority;Safety;Sickle Cell Anemia;socioeconomics;Splenomegaly;Techniques;Testing;Therapeutic;therapeutic gene;tool;Transplantation;Validation;vector;Work

PROJECT_TITLE: Development and validation of novel mouse models and expression vectors for characterizing severe alpha-thalassemia pathophysiology and evaluating gene therapy approaches.

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WAIANAE

ORG_NAME: WAIANAE COAST COMPREHENSIVE HEALTH CTR

ORG_STATE: HI

PI_NAMEs: OKIHIRO, MAY MICHIKO (contact)

PROGRAM_OFFICER_NAME: MADDEN, EBONY B

PROJECT_TERMS: Address;Adult;care systems;Caring;Chronic;Clinic;Cognitive Therapy;Collaborations;Communication;Communities;community organizations;Complex;Consensus;COVID-19 pandemic;cultural values;data dissemination;data sharing;Diabetes Mellitus;Disparity;economic outcome;Ecosystem;Education;Educational Curriculum;Educational Models;empowerment;Equilibrium;Ethnic Population;evidence base;Family;Fostering;graduate school;Hawaii;Hawaiian;healing;Health;health disparity;Health education;Health Services Accessibility;Healthcare;Healthcare Systems;high school;Imprisonment;improved;Indigenous;Information Dissemination;innovation;insurance plan;intergenerational;Interruption;Intervention;Island;Knowledge;Laws;Learning;Life;Life Expectancy;local economy;member;Mental Health;Mental Health Services;Mentorship;Methods;Modeling;Modernization;Movement;Multicultural Education;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Neighborhood Health Center;Nutrition management;Obesity;Outcome;Pacific Islander;Parents;Personal Satisfaction;Persons;pilot test;Policies;Policy Maker;Population;Poverty;Prevalence;Prevention;Process;Public Health;Qualifying;racial population;Renaissance;Research;resilience;Resources;Risk;Schools;Sea;Services;Spirituality;structural determinants;Students;Support System;System;Testing;Trauma;Work;young adult;Youth

PROJECT_TITLE: Fostering Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT(01)-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: RIDGELAND

ORG_NAME: MY BROTHER'S KEEPER, INC.

ORG_STATE: MS

PI_NAMEs: GIPSON, JUNE ARNESSA (contact);SUTTON, VICTOR D

PROJECT_TERMS: Address;Adult;Age;Area;Award;Black race;Brothers;care delivery;Caring;Classification;Communities;community based participatory approach;community organizations;Complex;design;Education;Employment;Ensure;Environment;ethnic minority;Ethnic Origin;Funding;Future;Gays;Health;health care availability;health care quality;health care service;Health Disparities Research;Health equity research;Health Priorities;Health Professional;Healthcare;Healthcare Systems;Heterosexuals;HIV;HIV/STD;holistic approach;implementation evaluation;improved;Incidence;indexing;Individual;Inequity;innovation;Intervention;intervention mapping;Laws;male;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Medical center;men;minority communities;minority health disparity;Mississippi;Outcome;Personal Satisfaction;Phase;Population;Practice Guidelines;Preventive healthcare;Process;programs;Race;racial minority;Regulation;reproductive;Reproductive Health;reproductive outcome;Research;Resources;Rights;Rural;Sex Orientation;Sexual and Gender Minorities;sexual and reproductive health;Sexual Health;Sexually Transmitted Diseases;social;social vulnerability;structural determinants;telehealth;transgender;Universities;Voice;Woman

PROJECT_TITLE: Achieving Optimal Sexual and Reproductive Health (SRWH Project)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: MIGRANT CLINICIANS NETWORK, INC.

ORG_STATE: TX

PI_NAMEs: GARCIA, DELIANA  (contact);LOPEZ-CORREA, ANIBAL YARIEL;MADARAS, LAZSLO

PROJECT_TERMS: Address;Attention;barrier to care;Birth;Caring;Case Management;Child;Child Health;Chronic Disease;Collaborations;Communities;community engaged research;Community Health;community organizations;Complex;Data;Databases;Destinations;Electronics;Enrollment;Epilepsy;Face;Familiarity;Fostering;Health;health care availability;health disparity;health disparity populations;health equity;Health equity research;health inequalities;Health Services Accessibility;Healthcare;high risk population;Home;Immigrant;Immigration;improved;Influentials;Injury;innovation;Intervention;Limited English Proficiency;longitudinal care;Managed Care;Medical;medical vulnerability;Migrant;Modeling;novel;Occupations;Outcome;participant enrollment;Patients;Pharmaceutical Preparations;Policies;policy implication;Population;Pregnant Women;Prenatal care;Privatization;Process;programs;Refugees;Reporting;Research Project Grants;Resources;Risk;Schools;service providers;Services;Shelter facility;System;Third Pregnancy Trimester;United States;volunteer;Work

PROJECT_TITLE: Humanitarian Health Care Network: Bringing the Most Vulnerable to Care


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: LINCOLN

ORG_NAME: FEONIX - MOBILITY RISING

ORG_STATE: NE

PI_NAMEs: LEFLER, VALERIE  (contact)

PROJECT_TERMS: Advocate;Budgets;Caring;Communities;Electronics;ethnic minority population;experience;follow-up;Health;health care availability;health care service;Health Resources;improved;improved mobility;Individual;inner city;Intervention;Justice;Michigan;neighborhood disadvantage;nutrition;Personal Satisfaction;Poverty;Preventive;programs;racial minority population;Reduce health disparities;Research;Resources;Safety;Services;social health determinants;Socioeconomic Status;System;Texas;Transportation;transportation access;United States;Work

PROJECT_TITLE: Reducing Health Disparities through Enhanced Mobility Support and Access


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BETHEL

ORG_NAME: YUKON-KUSKOKWIM HEALTH CORPORATION

ORG_STATE: AK

PI_NAMEs: KECK, JAMES W.;LEFFERTS, BRIAN  (contact)

PROJECT_TERMS: Adult;Agriculture;Alaska;Alaska Native;Alaska Native population;arctic environment;Blood Glucose;Blood Pressure;Body mass index;Cholesterol;Chronic;Clinical;Communities;community engaged approach;Consumption;cost;Diabetes Mellitus;Diet;Disease;Disease Progression;Disparity;Economics;Employment;experience;Family;Fishes;Food;food insecurity;food marketing;food preparation;Food production;food security;fruits and vegetables;good diet;Harvest;Health;health disparity;Health Food;Heart Diseases;Home;Hunger;Hypertension;Improve Access;improved;innovation;Intervention;Knowledge;Life Expectancy;Life Style;Malignant Neoplasms;Measures;member;Methods;Modeling;Movement;Nutrient;nutrition;Nutritional;Obesity;obesity in children;Participant;Persons;Policies;Recommendation;Regulation;resilience;Rural;Rural Community;sound;System;Training;tribal community;Tribes;Unhealthy Diet;Vision;Work;Yukon-Kuskokwim Delta

PROJECT_TITLE: Neqkiuryaraq - The Art of Preparing Food


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MUSKEGON

ORG_NAME: ACCESS HEALTH INC

PI_NAMEs: CORNELL, SAMANTHA CAROL (contact)

PROJECT_TERMS: Address;Affect;Businesses;Caring;Child Care;Clinical;Collaborations;Collection;Communities;community partners;Complex;contextual factors;County;Data;data platform;design;economic impact;Economics;Educational Status;Eligibility Determination;Employee;Employment;Employment Status;Equity;experience;falls;Family;federal poverty level;Health;health disparity;health equity;Health equity research;Health Priorities;holistic approach;Household;improved;Income;Individual;innovation;Intervention;intervention program;Investigation;Investments;Knowledge;Legal;Link;Low income;low socioeconomic status;lower income families;Mediating;Medicaid;Minority Groups;Organizational Policy;Outcome;Periodicals;Policies;Poverty;Privatization;Process;programs;Qualifying;recruit;Reduce health disparities;Research;Research Project Grants;Resources;Role;Rural Population;safety net;Security;social;social health determinants;Stress;Structure;Transportation;Trust;Underemployment;Unemployment;Wages;Work

PROJECT_TITLE: Strengthening Community-Driven Safety-Net Interventions to Improve Health and Economic Equity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: Clinton Twp

ORG_NAME: FACE ADDICTION NOW

PI_NAMEs: WALLER, RAYMOND  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Area;Automobile Driving;Behavioral;behavioral health;Caring;Chronic;Chronic Care;Collaborations;collaborative care;Communities;community partnership;Community Services;Complex;Continuity of Patient Care;court;Criminal Justice;design;Disparate;Disparity;disparity gap;dual diagnosis;Ecosystem;Emergency Situation;Environment;Etiology;experience;flexibility;follow-up;Fracture;Geography;Goals;Government;Grant;Health;health disparity;health inequalities;health professional shortage areas;Health Services Accessibility;Health system;Healthcare;Hospitals;Housing;Human;improved;Individual;innovation;interest;Intervention;Jail;Knowledge;Linguistics;Link;Lived experience;Longterm Follow-up;Maps;marginalization;Mediation;Medical;member;Michigan;Mission;Modeling;Monitor;multiple chronic conditions;Nature;Outcome Measure;Pathway interactions;peer;peer support;Persons;physical conditioning;Population;protective factors;Provider;Public Health;Recovery;referral services;Reporting;Research;resilience;Resources;Rural;service gap;Service setting;Services;social health determinants;Stigmatization;System;telehealth;Testing;United States Dept. of Health and Human Services;United States National Institutes of Health;urgent care;virtual;Work

PROJECT_TITLE: Creating Statewide Community Partnerships: Spanning Boundaries between Public Health, Emergency Housing & Criminal Justice


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_NAME: GRUPO NEXOS INC.

ORG_STATE: PR

PI_NAMEs: ADAMES, CRISTINA ;ERIC, RIVERA ;SANCHEZ, MARIZAIDA  (contact);SARDIÑAS, LILI M.

PROJECT_TERMS: Address;Adult;Affect;Attention;Behavioral;Caregivers;Categories;Child;child poverty;Communities;community engagement;Complex;cost;Crime;Data;data hub;Decision Making;design;Development;Disease;Economics;Educational Status;Employment;Environment;Equity;ethnic minority;Exhibits;Exposure to;Family;Fostering;Future;Generations;Health;health disparity;health equity;High Prevalence;Household;Human;improved;Income;Individual;innovation;intersectionality;Intervention;Intervention Studies;Laws;Leadership;Life;Life Cycle Stages;life span;lost earning;Measures;member;Methods;Modeling;Needs Assessment;Outcome;Personal Satisfaction;Policies;poor health outcome;Population;population health;Positioning Attribute;Poverty;Privatization;Process;Production;Productivity;programs;Puerto Rico;Recording of previous events;Research;Research Personnel;Resource Development;Resource-limited setting;Resources;rural area;scale up;service providers;Services;Shapes;social;social culture;social disparities;Social Environment;social health determinants;Societies;Socioeconomic Status;Strategic Planning;structural determinants;Time;tool;Trauma;Unemployment;United States National Academy of Sciences;Violence;Work;Youth

PROJECT_TITLE: Puerto Rico Collaborative Advancement of Research, Innovations, Best Practices and Equity for Children, Youth and Families (PR-CARIBE)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: BRONXWORKS, INC.

PI_NAMEs: MARCH, JENNIFER ;TORRES, EILEEN  (contact)

PROJECT_TERMS: Address;Administrator;Adult;Advocacy;Affect;Age;Anxiety;Asbestos;authority;Behavior;Books;cardiometabolism;Child;Child Care;child day care;Child Development;Cities;Collaborations;college;Communities;community partnership;Complex;County;Credentialing;Data;data management;design;Development;Economics;Education;eHealth;Emotional;Excision;Family;food insecurity;Fostering;Foundations;Government Agencies;Head;Health;health disparity;health equity;Health equity research;Health Personnel;Health Services;Health Services Accessibility;Home;Household;Housing;Human;improved;Income;Individual;innovation;Institution;Institutional Policy;interest;Intervention;lead paint;Managed Care;Medical center;Medicine;Modeling;Molds;Needs Assessment;New York;New York City;nutrition;Outcome;Parents;Persons;Phase;Policies;poor health outcome;Poverty;Privatization;Process;Process Assessment;Property;psychosocial;Public Health;Public Housing;Reduce health disparities;Research;research study;service organization;service providers;social;social health determinants;Social Work;statistics;Stress;Structure;United States;Work;working group

PROJECT_TITLE: Healthy and Livable Bronx Partnership


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: SOMERTON

ORG_NAME: CAMPESINOS SIN FRONTERAS

PI_NAMEs: TORRES, EMMA  (contact)

PROJECT_TERMS: Address;Arizona;Chronic Disease;Collaborations;Communities;community based participatory research;Community Health Aides;Competence;Economics;Environmental Exposure;Equity;Face;Family;farm worker;Health;health care availability;Health equity research;Health Insurance;Housing;Injury;Intervention;Laws;member;Mental Depression;Methods;Nature;Outcome;Participant;Process;Punishment;Research;Risk;Seasons;Series;Services;social;stem;Stress;structural determinants;structural health determinants;Unemployment;Wages;Work

PROJECT_TITLE: Achieving Equity in Farmworker Health Through Community-Led Research


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: MISSOULA

ORG_NAME: OPEN AID ALLIANCE

ORG_STATE: MT

PI_NAMEs: RAMOS, REBECCA  (contact)

PROJECT_TERMS: barrier to care;care systems;Caring;Chronic;Client;clinical training;combat;County;Death Rate;Diagnosis;Education;Equity;Evidence based intervention;experience;General Population;geographic difference;Health;Health Occupations;Health Personnel;Health Services Accessibility;Homelessness;Indian reservation;Individual;innovation;Intervention;Measures;Medicaid;medication for opioid use disorder;Modeling;Monitor;Montana;Needle-Exchange Programs;Nurses;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;patient oriented;Patients;peer;Persons;Population;prescription opioid;prevent;primary outcome;reduced substance use;Rural;rural area;Self Efficacy;service programs;Site;Specialist;Stigmatization;structural determinants;Substance Use Disorder;Time;Trauma;Trust;Underserved Population;urban area;willingness

PROJECT_TITLE: Counteracting Structural Barriers to Increase Access to Medications for Opioid Use Disorder (MOUD) Among Unhoused Montanans


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MIAMI

ORG_NAME: URBAN HEALTH PARTNERSHIPS

PI_NAMEs: IGLESIAS, ANDREA  (contact)

PROJECT_TERMS: Address;Adult;Advocacy;Age;citizen science;Collaborations;Collection;Communities;Community Actions;community partners;contextual factors;County;dashboard;Data;data access;Data Collection;data dashboard;data sharing;design;Development;Disparity;empowerment;experience;Foundations;Funding;Future;Gender Identity;gender minority community;gender minority group;gender minority health disparity;Geographic Locations;Health;health care availability;health data;Health Disparities Research;health disparity;Health equity research;Health Promotion;Healthcare;Homelessness;Housing;implementation intervention;Improve Access;improved;Inequity;Information Systems;innovation;Institutional Racism;intergenerational;intersectionality;Intervention;Lesbian Gay Bisexual Transgender Queer;life span;member;Methods;Minority Groups;model generalizability;Modeling;neglect;Outcome;outreach;Periodicals;Personal Satisfaction;Phase;Policies;Policy Maker;Politics;Population;programs;psychological outcomes;Remunerations;Research;Research Design;Research Personnel;Resources;service providers;Sex Orientation;Sexual and Gender Minorities;sexual minority group;social health determinants;Surveys;System;Target Populations;timeline;tool;United States National Institutes of Health;Update;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Leveraging a community-driven approach to address the impact of social determinants of health on structural inequities among Miami-Dade County's intergenerational LGBTQ+ Community


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: ASIAN AMERICAN HEALTH COALITION/HOUSTON

PI_NAMEs: CARACOSTIS, ANDREA  (contact)

PROJECT_TERMS: Address;Area;Asian Americans;Awareness;Behavior;Black race;Chest;Child;children of color;Clinic;Communication;Communities;community engagement;community involvement;community transmission;Community-Led Health Equity Structural Intervention;Disparity population;Ensure;Environment;Equity;ethnic diversity;Evidence based intervention;experience;Family;Food;food insecurity;Health;health disparity;health equity;health inequalities;Height;Hispanic;improved;Individual;Inequity;innovation;insight;Intention;Intervention;Lasers;Learning;life span;Lived experience;marginalization;Measurement;Measures;member;Methodological Studies;Methodology;Mission;Nutritional;Outcome;Pacific Islander;pandemic disease;Personal Satisfaction;Persons;Phase;Policies;Population;Prejudice;Preparation;Process;Process Assessment;programs;racial diversity;Research;Research Methodology;Resistance;Sea;Secure;Source;systemic barrier;Texas;Theory of Change;tool;United States Department of Agriculture;Universities;Work

PROJECT_TITLE: Addressing Systemic Barriers Impacting Health in CHC Communities