NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Lung;Social Determinants of Health

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Ground-level ozone is a major pollutant that increases the risk of morbidity in people with asthma. Our preliminary data demonstrate that ragweed pollen, one of the most common airborne allergens, retains changes from ozone exposure that result in increased pulmonary inflammation in vivo in a model of asthma. The goal of this project is to identify the chemical and structural changes in ragweed induced by ozone exposure and the immunologic mechanisms by which ozone exposed ragweed induces greater pulmonary inflammation.

PI_NAMEs: JACOBSEN, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;aerosolized;Affect;Air;Air Pollution;airborne allergen;airway epithelium;airway immune response;airway inflammation;Allergic Disease;Alveolar Macrophages;Ambrosia;Asthma;asthma exacerbation;asthma model;Atmosphere;atmospheric conditions;Biochemistry;Biological;Biological Assay;Biopolymers;Cell surface;Chemicals;Chemistry;chemokine;Chemotaxis;Chronic;Cities;clinical translation;cytokine;Data;Disease;Environment;eosinophil;Epithelial Cells;experience;Exposure to;Extrinsic asthma;Functional disorder;Future;Goals;Grain;Growth;human disease;Humidity;Immune System Diseases;Immunologics;immunopathology;In Vitro;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-6;Intervention;lipid mediator;Lipids;Literature;Lung;Mass Fragmentography;Measures;Medical;Modeling;Molecular;Morbidity - disease rate;Morphology;mouse model;Nature;neutrophil;Neutrophil Infiltration;Nitric Oxide;Nitrogen;Outcome;Oxygen;Ozone;ozone exposure;particle;Pathway interactions;Persons;Phagocytes;Pollen;pollutant;Pollution;Population;Positioning Attribute;Production;pulmonary function;Pulmonary Inflammation;Reactive Oxygen Species;response;Risk;Role;Rupture;Scanning Electron Microscopy;Source;Spectroscopy, Fourier Transform Infrared;Structure;Surface;System;Testing;tropospheric ozone;Ultraviolet Rays

PROJECT_TITLE: Pulmonary Response to Ozone-exposed Ragweed Pollen Grains

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Pediatric;Pulmonary Hypertension

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Pediatric pulmonary hypertension (PPH) is a progressive, incurable disease caused by abnormal smooth muscle growth and development of “neointimal lesions” that block blood flow through arteries and veins, with devastating outcomes when venous disease predominates. We have no treatments that target venous lesions because we know very little about what controls their growth and therefore, in these experiments we are 1) defining the transcriptional signature of vein neointima across the lifespan of a lesion to understand the mechanisms driving growth, 2) identifying molecules that control the growth of vein neointima cells, and 3) using new information about distinct smooth muscle cell subsets present during normal human lung development to understand how vascular disease develops in children with PPH, including the growth of vein neointima. We hope that a more complete understanding of the cells and signals driving venous neointimal formation and vascular remodeling in pediatric pulmonary hypertension will lead to a new generation of pediatric disease specific therapies that improve the lives of children with PH.

PI_NAMEs: STEFFES, LEA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Age;Arteries;Automobile Driving;Basic Science;Behavior;biocomputing;Bioinformatics;Biology;biomarker panel;Blood capillaries;Blood flow;Blood Vessels;candidate identification;capillary bed;career;cell growth;cell transformation;cell type;Cells;cellular pathology;Child;Childhood;Clinical;combat;Cues;Cytology;Data;Data Analyses;Data Set;Development;Disease;effective therapy;Endothelium;Environment;Epithelium;experimental study;FOXF1 gene;Future;Gene Expression Profile;Generations;Genetic;Genetic Markers;genetic signature;genome-wide;genomic tools;Genomics;Glean;Goals;Growth;Growth and Development function;Health;Heritability;Heterogeneity;Histopathology;Human;Image;improved;In Situ;In Situ Hybridization;In Vitro;in vivo;Infrastructure;innovation;insight;Investigation;Lesion;life span;Link;Literature;Lung;lung development;Mentors;Molecular;Molecular Profiling;mouse genetics;mouse model;Mus;Muscle;neointima formation;notch protein;NOTCH3 gene;novel;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Platelet-Derived Growth Factor;Population;postnatal;prevent;Proliferating;Publications;Publishing;Pulmonary Hypertension;Pulmonary Pathology;pulmonary vascular disorder;Pulmonary vessels;Research;Role;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Smooth Muscle;Smooth Muscle Myocytes;SOX17 gene;Structure of parenchyma of lung;Techniques;therapeutic target;Tissue Banks;tool;Training;transcriptomics;Transgenic Mice;Translational Research;Universities;vascular abnormality;vascular bed;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Vasodilator Agents;Veins;Venous;Work

PROJECT_TITLE: Exploiting neointimal and vascular smooth muscle cell heterogeneity to reveal mechanisms driving venous neointimal growth and vascular remodeling in pediatric pulmonary hypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Clinical Research;Immunotherapy;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Respiratory viral infections in neonates and infants are associated with increased acute morbidity and an increased long-term risk of developing asthma. This proposal aims to understand the unique intrinsic and extrinsic mediators of the altered CD4+ T cell response following human metapneumovirus infection in neonatal mice. Further, this proposal will evaluate the long-term effects of neonatal human metapneumovirus infection on formation of tissue resident memory cells and the role of these cells in asthma pathogenesis.

PI_NAMEs: EDDENS, TAYLOR JOHN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 1 year old;5 year old;Acute;Adaptive Immune System;Address;Adoptive Transfer;Adult;airway hyperresponsiveness;Anti-Inflammatory Agents;antiviral immunity;Asthma;Bioinformatics;Biological Assay;Bronchiolitis;career development;CD4 Positive T Lymphocytes;Cells;Cellular Metabolic Process;Cessation of life;Child;Childhood;Chronic;Clinical;cytokine;Data;Development;Diagnosis;Disparate;druggable target;early childhood;Environment;eosinophil;Epigenetic Process;Exhibits;experimental study;Exposure to;fatty acid oxidation;Follow-Up Studies;FRAP1 gene;Gene Expression Profile;Genetic Transcription;Genus Hippocampus;Goals;Growth;Hospitalization;Human Metapneumovirus;human model;Immune system;Immunology;in vivo;Infant;Infection;inhibitor;Lead;Life;Literature;Long-Term Effects;Lower Respiratory Tract Infection;Lung;Lymphocyte;Mediating;Mediator;Memory;memory CD4 T lymphocyte;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Morbidity - disease rate;mouse model;Mucous body substance;Mus;Neonatal;neonatal human;neonatal immune system;neonatal infection;Neonatal lung;neonatal mice;Neonatal Mortality;neonate;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathology;Pathway interactions;pediatrician scientist;Pediatrics;pharmacologic;Phenotype;Population;Predisposition;preference;prevent;Prevention strategy;Production;recruit;Regulatory T-Lymphocyte;respiratory;Respiratory Tract Infections;response;Risk;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Sirolimus;T cell differentiation;T cell response;T-Lymphocyte;Testing;Th1 Cells;Th2 Cells;Therapeutic;Tissues;Training;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Altered CD4+ T cell responses and resultant asthma following neonatal human metapneumovirus infection

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE  Psychosocial health problems among U.S. adolescents are on the rise and have a disproportionate impact on immigrant youth. While research indicates that peer friendships are crucial for adolescent psychosocial health, the specific ways in which differences in friendship patterns and processes between immigrant and nonimmigrant youth contribute to health outcome disparities remain unclear. This proposed research aims to address this gap by using new friendship network data and employing social network analysis to examine the mechanisms within school and non-school friendships that may exacerbate psychosocial health problems among immigrant youth.

PI_NAMEs: KHUU, THOA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Affect;analytical method;Anxiety;Anxiety Disorders;Applications Grants;Area;Asian;authority;career;Child;Communities;Complement;Data;Data Collection;data resource;Data Set;depressive symptoms;design;Destinations;Development;Disparity;Education;Empirical Research;ethnoracial minority;experience;Face;Family;forging;Friends;Friendships;Generations;Goals;Grant;Health;health outcome disparity;Heterogeneity;High Prevalence;Immigrant;Individual;insight;Investigation;Knowledge;Lead;Life;Literature;Longitudinal Studies;Measures;Mediating;Mental disorders;method development;Methods;Moods;Nature;network models;Not Hispanic or Latino;Outcome;Pathway Analysis;Pattern;peer;Personal Satisfaction;Phase;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Process;psychologic;Psychometrics;psychosocial;Refugees;Research;Research Personnel;Risk;Role;Sampling;Schools;self esteem;Shapes;Social Environment;social integration;Social Network;Sociology;Surveys;Testing;Time;Training;United States;Vulnerable Populations;Youth

PROJECT_TITLE: Adolescent Friendship Networks: Effects on Immigrant Youth’s Psychosocial Health

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Assistive Technology;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Urologic Diseases

ORG_CITY: IRVINE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Our research project aims to improve the treatment of coronary artery calcification (CAC) by developing metasurface optical guidewires, which have the potential to revolutionize percutaneous coronary interventions (PCIs). Through precise control of laser dosimetry and the use of laser intravascular lithotripsy (L-IVL), these novel devices could significantly enhance the treatment of calcified stenotic arteries. Successful development and testing of novel metasuface optical guidewires will allow conducting PCI in highly stenotic and calcified arteries to provide therapy and increase vessel compliance.

PI_NAMEs: KATTA, NITESH  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acute;Address;aging population;Animal Model;animal model development;Arteries;Atherectomy;calcification;Calcium;cardiac pacing;Cardiology;Cardiovascular system;Catheterization;Clinical;Clinical Management;Collaborations;Coronary;Coronary Arteriosclerosis;coronary artery calcification;cost;Coupled;design;Development;Devices;Diagnosis;Diagnostic;Diameter;dosimetry;drug distribution;Elements;Event;experience;Failure;Feedback;Fiber;Fiber Optics;flexibility;Fluoroscopy;Fracture;Future;Goals;good laboratory practice;Heart;high risk;Human;Image;image guided;image guided intervention;Imaging Techniques;improved;in vivo;innovation;Intervention;Intervention Studies;Lasers;lens;Lesion;Light;Lithotripsy;manufacture;Mechanics;Mentors;Methods;millimeter;Modeling;next generation;novel;Optical Coherence Tomography;Optics;Oryctolagus cuniculus;Outcome;Patient Care;Patients;percutaneous coronary intervention;porcine model;pre-clinical;Pre-Clinical Model;pre-clinical research;Precision therapeutics;Procedures;Radial;Regrets;Research;Research Project Grants;restenosis;Safety;Shock;skills;stent thrombosis;Stents;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;tool;Training;Treatment Efficacy;ultrasound

PROJECT_TITLE: Metasurface Optical Guidewire for percutaneous coronary intervention (PCI)

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects 1 in 36 children in the United States. Somatic variants, variants that arise after fertilization, have been implicated in ASD risk, but the types of variants that are enriched in ASD probands as well as the potential contribution of somatic variants in non- coding gene regulatory regions are largely unknown. This proposal will apply innovative approaches to test the hypothesis that somatic variants in both gene coding and gene regulatory regions contribute to ASD risk and can reveal new genes and mechanisms involved in ASD.

PI_NAMEs: MO, ALISA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Advisory Committees;Affect;ATAC-seq;autism spectrum disorder;Autopsy;Binding Sites;Biological Assay;Biomedical Research;Blood;Boston;Brain;brain control;Brain Diseases;brain tissue;Candidate Disease Gene;career;career development;Child;Chromatin;Clinical;clinical phenotype;clinical practice;clinical training;Code;comparison control;Complement;Complex;Computational algorithm;Computer Analysis;Data;deep sequencing;Detection;Development;disorder risk;Environment;exome sequencing;Exons;experience;Family;Fertilization;Flow Cytometry;Fostering;Foundations;Future;Genes;Genetic;genetic architecture;genetic disorder diagnosis;Genetic Enhancer Element;genetic testing;genome sequencing;Genomics;Genotype;Goals;Human;Human Genetics;improved;Individual;individuals with autism spectrum disorder;innovation;Institution;Location;loss of function;medical schools;Mentors;Mentorship;Methods;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neurology;Neurons;next generation sequencing;Nucleic Acid Regulatory Sequences;Pathogenesis;Pediatric Hospitals;Phenotype;Physicians;Positioning Attribute;Prefrontal Cortex;proband;professor;programs;Research;Research Personnel;Research Training;Resources;Role;Saliva;Sample Size;Scientist;Siblings;Single Nucleotide Polymorphism;skill acquisition;skills;Somatic Mutation;Sorting;Testing;Tissues;Tn5 transposase;Training Programs;transcription factor;transmission process;Transposase;United States;United States National Institutes of Health;Untranslated RNA;Variant;variant detection;whole genome

PROJECT_TITLE: Somatic mutations in autism spectrum disorder

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Lung;Lung Cancer;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will increase our understanding of critical cigarette smoking treatment barriers for people living with intellectual and developmental disabilities. This project will also bridge a significant treatment-focused research gap between people with intellectual disabilities and the general population. The studies proposed in this K99/R00 will identify and adapt a tailored evidence-based smoking cessation treatment for people with intellectual and developmental disabilities (IDDs) utilizing stakeholder feedback and perspectives.

PI_NAMEs: REGNIER, SEAN  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adult;Alcohols;Asthma;Award;Behavior Therapy;Behavioral;Carbon Monoxide;career development;Cessation of life;cigarette smoking;Clinical;Clinical Trials;Collaborations;Communities;community engaged approach;community engagement;Consult;contingency management;Data;design;Development;Developmental Disabilities;Diabetes Mellitus;Disadvantaged;Disease;Dropout;Drops;Enrollment;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;Exclusion;experience;feasibility trial;Feedback;Foundations;Future;General Population;Goals;Grant;Health;health equity;Healthcare;Human Development;illicit drug use;Impairment;implementation science;improved;Incentives;individualized medicine;Intellectual functioning disability;Intervention;Interview;Lived experience;Maps;Measures;Mentors;Mentorship;Modeling;Modernization;Modification;Outcome;Participant;Pathway interactions;Patient Self-Report;Patients;Persons;Pilot Projects;Population;Positioning Attribute;Poverty;Preparation;preventable death;primary outcome;Probability;Process;Provider;Publishing;Quality of Care;Randomized, Controlled Trials;Research;Research Training;Review Literature;Risk;secondary outcome;skills;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking treatment;social health determinants;social stigma;substance use;Suggestion;systematic review;Testing;Time;Tobacco;Tobacco use;Tobacco Use Disorder;Token Economy;Training;treatment research;United States;Vocabulary;Vulnerable Populations;Work

PROJECT_TITLE: Adapting and Testing a Smoking Cessation Intervention in Adults with Intellectual and Developmental Disabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Adolescents and young adults with sarcomas suffer a significant burden of morbidity and mortality with minimal improvements in outcomes in recent decades. The presence of metastatic disease remains the only strong prognostic factor, and biomarkers are needed to inform new approaches to testing risk-stratified therapy. In the proposed study, I will determine prognostic thresholds for ctDNA burden for fusion-positive and fusion negative sarcomas leveraging structural features seen across all sarcomas and then assess the impact of clinical ctDNA testing for post-treatment surveillance in Ewing sarcoma.

PI_NAMEs: SHULMAN, DAVID  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adolescent and Young Adult;Affect;Aftercare;Aneuploidy;Biological Assay;Biological Markers;Biology;biomarker development;biomarker driven;biomarker validation;Biopsy;candidate marker;career development;Cessation of life;Characteristics;chemotherapy;Clinical;clinical care;Clinical Data;clinical translation;Clinical Trials;cohort;Colorectal Cancer;Complex;conventional therapy;Dedications;Detection;Development;Development Plans;Diagnosis;Diagnostic;Disease;Disease Surveillance;disorder risk;disorder subtype;DNA analysis;Evaluation;Ewings sarcoma;falls;Frequencies;Future;Genome;Genomics;Goals;Hand;Heart Diseases;high risk;Histology;improved;improved outcome;individualized medicine;Infertility;Late Effects;Lead;Leadership;Left;liquid biopsy;Malignant Fibrous Histiocytoma;Malignant Neoplasms;Metastatic Ewing's Sarcoma;Molecular;molecular marker;Morbidity - disease rate;mortality;new technology;novel;novel marker;novel strategies;novel therapeutics;Operative Surgical Procedures;Osteosarcoma;Outcome;Patient Selection;Patients;pediatric acute leukemia;Pediatric Oncology Group;phase III trial;Pilot Projects;Population;Positioning Attribute;prognostic;Prognostic Factor;Prognostic Marker;programs;prospective;Prospective Studies;Radiation;Recurrent disease;Relapse;relapse risk;Research;research and development;research clinical testing;response;Risk;risk stratification;Sampling;Sarcoma;Scanning;Second Primary Cancers;Series;skills;Soft tissue sarcoma;Specimen;survival outcome;Survivors;synovial sarcoma;Technology;Test Result;Testing;Time;Tissues;Toxic effect;Training;treatment response;trial design;tumor;tumor DNA;Validation;validation studies;Variant;willingness

PROJECT_TITLE: Validation and implementation of ctDNA as a clinically informative biomarkerin AYAs with sarcomas.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Alzheimer’s disease is a common aging disorder characterized by progressive loss of brain cells and decline in memory and thinking. Identifying the genetic factors that promote risk of Alzheimer’s disease and understanding how these genetic factors contribute to disease risk could lead to better tools for diagnosis, prognosis, and treatment. This study will understand how one form of gene mutation called short tandem repeats contributes to our risk of onset and rate of progression in Alzheimer’s disease.

PI_NAMEs: GUO, MICHAEL HAOMING (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;age effect;Age of Onset;aging related disease;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;area striata;Autopsy;Back;Blood;brain cell;Brain region;brain tissue;career;Cell Line;Cell Survival;Clinical;Cognitive;cohort;Complement;Complex;CRISPR/Cas technology;Data;Defect;density;Diagnosis;Disease;disease phenotype;Disease Progression;disorder risk;DNA;Foundations;Gene Expression;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Risk;Genetic Variation;Genome;Genome engineering;genome sequencing;genomic biomarker;Genomics;Genotype;Goals;Human Genetics;human genomics;Huntington Disease;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;insight;Knowledge;Length;Measures;Memory;Mentors;Mentorship;Molecular;Molecular Genetics;Nerve Degeneration;Nervous System Disorder;Neurologist;Neuronal Differentiation;Neurons;neuropathology;novel;Odds Ratio;Onset of illness;Pathogenicity;Physicians;Prognosis;Risk;Role;Sampling;Scientist;Short Tandem Repeat;skills;Sorting;Source;stem cell model;stem cells;Structure of middle temporal gyrus;Synapses;synaptogenesis;Temporal Lobe;Testing;Thinking;Tissues;tool;Training;Variant;whole genome;Work

PROJECT_TITLE: Short tandem repeats as a novel genetic driver of Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_DEPT: PATHOLOGY

PI_NAMEs: GALLI, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TITLE: Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative: Understanding the intrinsic factors that regulate T and B lymphoid development from HSPCs is key to understanding hematopoietic system function in health, stress, and pathology. Self-renewal and lymphoid priming mechanisms in HSCs have been shown to be mutually antagonistic. My studies aim to understand the transcriptional, clonal and epigenetic landscape that regulate lymphoid development from HSPCs in native hematopoiesis and perturbation.

PI_NAMEs: MESQUITTA, WALATTA-TSEYON WAZIRU (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Adult;Advisory Committees;Age;age related changes;antagonist;Attenuated;attenuation;Award;B cell differentiation;B-Lymphocytes;Blood;Bone Marrow;Bone Marrow Transplantation;career development;Cells;Chimerism;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Development;Doxycycline;drinking water;Embryo;Engraftment;Epigenetic Process;epigenomics;Fellowship;Frequencies;Genetic Transcription;Guide RNA;Health;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic System;immune function;Immune system;In Situ;In Vitro;in vivo;Infection;insight;Intrinsic factor;Knock-out;Laboratories;Lentivirus;Life;Liquid Chromatography;Lymphoid;Lymphoid Cell;Lymphopoiesis;Mediating;Mentors;Mentorship;Methods;Molecular;mortality;mouse model;Mus;Myelogenous;Natural regeneration;non-Native;Outcome;Output;overexpression;Pathology;peripheral blood;Phase;Phenotype;Population;post-transplant;progenitor;programs;Proteomics;reconstitution;regeneration potential;Regulation;repaired;Reporter;Research;self-renewal;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;stem cell differentiation;stem cells;Stress;System;T cell differentiation;T-Lymphocyte;tandem mass spectrometry;Technology;Testing;transcription factor;Transgenes;Transplantation;Water;Work

PROJECT_TITLE: Molecular regulation of lymphoid lineage priming in steady state and regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J1)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This K23 project seeks to address the critical gap in the utilization of pain psychology among socioeconomically disadvantaged patients with chronic low back pain (cLBP), a prevalent health issue contributing to health disparities. The project proposes a three-pronged approach: first, to quantify the effect of socioeconomic status on pain psychology utilization; second, to identify barriers to and facilitators of pain psychology services, which will guide the creation of a tailored intervention, the Empowering Pain Psychology Access and Collaboration (EPPAC); and third, to pilot the EPPAC intervention, assessing its acceptability, feasibility, and preliminary efficacy compared to usual care. The successful execution of this project will generate data and expertise, contributing to the PI's long-term goal of promoting equitable and effective use of evidence-based treatments among marginalized pain populations.

PI_NAMEs: RASSU, FENAN  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Applications Grants;Attitude;Award;Baltimore;Belief;career;career development;Caring;Chronic low back pain;chronic pain;Cities;Clinical;Clinical Investigator;clinical pain;clinical trial implementation;Cohort Analysis;Collaborations;comparative efficacy;comparison control;Control Groups;Data;Data Analyses;Development;Development Plans;Disparity;Distress;Drops;Economically Deprived Population;Education;effective therapy;effectiveness/implementation hybrid;Elements;empowerment;Environment;Equitable healthcare;Equity;Evaluation;evidence base;Evidence based treatment;experience;Funding;Future;Goals;Guidelines;Health;health care disparity;health disparity;health equity;health equity promotion;Health Personnel;Health Services Research;Health system;Healthcare Systems;implementation science;implementation tool;Improve Access;improved;Individual;individualized medicine;Institution;Insurance;Intervention;Interview;K-Series Research Career Programs;low socioeconomic status;marginalization;Medicaid;Medical;medical schools;Mentors;Methodology;Mission;Modification;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Outcome;Pain;Pain intensity;pain outcome;pain patient;pain reduction;Patient Care;patient engagement;patient oriented;patient subsets;patient-level barriers;Patients;Physical Function;Physical Medicine;Physical Rehabilitation;Population;professor;Psychologist;Psychology;Public Health Schools;Publishing;Qualitative Methods;Qualitative Research;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Training;Resources;Retrospective cohort;satisfaction;Scientist;Self Efficacy;Services;shared decision making;skills;Social Hierarchy;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Sodium Chloride;standard care;Structure;success;Time;Training;Training Activity;treatment as usual;treatment strategy;United States National Institutes of Health;Universities;usual care arm;virtual;Visit;Voice;Vulnerable Populations

PROJECT_TITLE: Research and Engagement for Advancing Chronic pain Healthcare Equity (REACH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Maternal infection during pregnancy is a known risk factor for offspring neurodevelopmental disorders, including autism and schizophrenia. Here, we use a nonhuman primate model of maternal immune activation in pregnancy to study changes in offspring behavior and brain structure, as well as postmortem changes in cellular and molecular organization. The goal of this research is to identify pathways and critical periods for the development of targeted interventions and therapeutics to improve mental health outcomes for individuals at- risk for severe neurodevelopmental disorders.

PI_NAMEs: HANSON, KARI L (contact)

PROJECT_TERMS: 4 year old;Acceleration;Adolescence;Adolescent;Affect;Age;Age Months;Amygdaloid structure;Anti-Inflammatory Agents;assay development;autism spectrum disorder;Autopsy;Award;Bacterial Infections;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;biobehavior;Biological Assay;Biological Markers;Biological Products;Biological Response Modifier Therapy;Biomedical Research;Brain;brain circuitry;brain tissue;California;career development;cell type;Cells;chemokine;Cognition;Cognitive;cohort;comparative;Complex;complex modeling;critical period;cytokine;Data;Data Collection;Development;Emotional;emotional behavior;Environment;Etiology;experimental study;Exposure to;fetal;Fluorescent in Situ Hybridization;Functional disorder;Funding;Goals;Grant;Growth;Growth Factor;Human;Immune;immune activation;Immune response;Immunology;improved;in vivo;Individual;Infection;Inflammatory;Institution;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;life span;Macaca mulatta;Maps;Medial;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Microglia;Modeling;Molecular;Neuroanatomy;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neuroimmune;neuroimmunology;neuroinflammation;NFKB Signaling Pathway;nonhuman primate;novel;offspring;Outcome;Pathway interactions;Pattern;Performance;Physiological;Physiology;Play;Postmortem Changes;postnatal development;Pre-Clinical Model;Prefrontal Cortex;Pregnancy;prenatal;prenatal exposure;Primates;Process;programs;Proteins;Proteomics;Quality of life;Research;Research Personnel;Risk;Risk Factors;Rodent;Role;Schizophrenia;Scientist;Side;single molecule;skills;social;Social Behavior;social cognition;structural imaging;Structure;symptomatology;Therapeutic;Time;Tissues;Training;Transcript;Translating;translational model;Translational Research;Viral;Virus Diseases;visual tracking;Water

PROJECT_TITLE: Brain and behavioral alterations in a nonhuman primate model of maternal immune activation: mPFC-amygdala circuitry, neuroinflammation, and socioemotional development


ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Prostate cancer, the fifth leading cause of cancer death in men globally, eventually fails standard of care entailing hormone therapy and chemotherapy for a large number of patients, which creates an urgency for new treatment plan(s) to delay or prevent the cancer from becoming terminal. We propose to investigate a new approach in which an inactive prodrug, to be synthesized by us, is activated specifically in tumor tissue, thus making it possible to deliver the prodrug at a very large dose to kill all cancer cells and prevent their ability to escape cell death by undergoing mutational changes under the pressure of therapy, while not causing unwanted side effects from indiscriminate toxicity in normal tissues. This study will be conducted in cultured prostate cancer cells and in prostate tumors that develop in mice from the injected cells, and a successful outcome of this preclinical project will lead to clinical trials on patients with advanced prostate cancer (and possibly other cancers) with a goal to test the activity of the novel prodrug, which we will synthesize, in the clinic.

PI_NAMEs: CHATTERJEE, BANDANA  (contact);ZHAO, JOHN CONG-GUI

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Ablation;Acrolein;advanced prostate cancer;Aldehydes;Allografting;androgen independent prostate cancer;Androgen Receptor;Androgens;Aneuploidy;anti-cancer;anti-cancer research;Antineoplastic Agents;Apoptosis;Azides;Binding;Biological;Biological Assay;Biological Products;Biological Response Modifier Therapy;bioluminescence imaging;bone;cancer cell;Cancer Etiology;Cancer Patient;Carbon;Castration;Cell Death;Cell Line;Cell model;Cell Proliferation;cell type;Cells;Centrosome;Cessation of life;Chemicals;Chemistry;chemotherapy;Chromosome Segregation;Clinic;Clinical;clinical translation;Clinical Trials;clinically relevant;Collaborations;Colonic Neoplasms;Data;Disease;docetaxel;dosage;Dose;drug candidate;Drug usage;Drug Utilization;Engineering;enzalutamide;Epithelial Cells;Firefly Luciferases;Goals;hormone therapy;Human;Immune;In Situ;In Vitro;in vitro Assay;in vivo;inhibitor;innovation;Invaded;Investigation;Left;luciferin;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;men;Meta-Analysis;Metabolism;Methods;migration;Mitomycin C;Mitotic spindle;Modeling;Mus;Mutation;Neoplasm Metastasis;Normal tissue morphology;novel;novel strategies;novel therapeutics;Organic Chemistry;Outcome;Oxidative Stress;Parents;Patients;PC3 cell line;Pharmaceutical Preparations;pre-clinical;preclinical study;Predisposition;pressure;prevent;Prodrugs;Prognostic Marker;Proliferating;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostatic Neoplasms;Proteins;Proto-Oncogene Proteins c-akt;Reaction;Receptor Signaling;Reporter;Reporting;Resistance;Resistance development;response;Roentgen Rays;side effect;Site;small molecule;small molecule libraries;Solid Neoplasm;standard of care;statistics;Synthesis Chemistry;System;TACC3 gene;taxane;Testing;Therapeutic;Therapeutic Index;therapy resistant;Tissues;Toxic effect;translational potential;treatment planning;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Tumor Tissue;Tumor Volume;Xenograft procedure

PROJECT_TITLE: Activation of Drug and Biologic Conjugates by Click Chemistry and their Tumor-selective Targeting for Prostate Cancer Suppression

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: GALVESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE This research project aims to better understand how cognitive abilities, such as memory and problem-solving skills, change as people age in Mexico. The study will use information reported by close family members or caregivers about these cognitive abilities and compare it with clinical assessments. The goal is to improve how we measure and understand changes in cognitive function, which is crucial for planning healthcare services and dementia care.

PI_NAMEs: CANTU, PHILLIP A (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Advanced Development;Age;Aging;aging population;Alzheimer's Disease;Ancillary Study;Area;Attention;career;career development;Career Mobility;Categories;Characteristics;Cities;Classification;Clinic;Clinical;Clinical assessments;Clinical Data;Cognition;cognitive ability;cognitive change;cognitive function;cognitive performance;cognitive testing;Competence;Complement;contextual factors;Country;Data;Dementia;dementia care;Diagnosis;Early Diagnosis;Education;experience;Extramural Activities;Family;Family Caregiver;family caregiving;Family member;Funding;Future;Gender;Geriatrics;Goals;Grant;Health;health care service planning;Impaired cognition;Impairment;improved;informant;Internal Medicine;International;Intervention;Knowledge;Leadership;leadership development;Life Cycle Stages;Link;literacy;Longitudinal Studies;low and middle-income countries;Manuscripts;Measurement;Measures;Medical;Memory;Mentors;Methods;Mexican;Mexican Americans;Mexico;mild cognitive impairment;older adult;Palliative Medicine;Participant;Pattern;Persons;Pharmacotherapy;Population;population based;Population Heterogeneity;Population Study;Populations at Risk;Prevalence;Problem Solving;professor;programs;Protocols documentation;Questionnaires;Reporting;Research;Research Personnel;Research Project Grants;residence;Sampling;screening;skills;social;social factors;socioeconomics;Statistical Methods;Survey Methodology;Surveys;symptomatology;Texas;tool;Training;Training Activity;Training Programs;trend;Universities;Update;Validation;Woman;Work;Writing

PROJECT_TITLE: Informant Measures Of Cognitive Decline In Mexico

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Primary immune regulatory disorders (PIRD) are a rapidly expanding subset of inborn errors of immunity characterized by disorganized and aberrant immune responses, and often present with variable manifestations such as autoimmunity and infectious complications. This project will investigate the development of antigen- specific responses and cellular factors contributing to T cell dysregulation in STAT3 gain-of-function syndrome, a known monogenic PIRD. Results from these studies have the potential to uncover new biomarkers, targetable cellular pathways, and further insight into disease pathogenesis and human immunology.

PI_NAMEs: SCHMITT, ERICA G (contact)

PROJECT_TERMS: acute infection;Advisory Committees;Antigen-Presenting Cells;Antigens;atopy;Autoimmune;Autoimmune Diseases;Autoimmunity;autosome;B-Lymphocyte Subsets;B-Lymphocytes;Biological Markers;career development;Cell Differentiation process;Cell Physiology;Cells;Clinical;congenital immunodeficiency;cytopenia;Data;Defect;Dendritic Cells;Development;Development Plans;Diagnostic;Disease;disease classification;early onset;Effector Cell;efficacy evaluation;Environment;Equilibrium;FOXP3 gene;gain of function;gammaherpesvirus;Generations;Genetic Diseases;Genetic Transcription;Germ Lines;Goals;Grant;Growth;Helper-Inducer T-Lymphocyte;Human;Humoral Immunities;Immune;Immune response;Immune system;Immune System Diseases;Immunity;Immunologics;Immunology;Immunophenotyping;Impairment;in vitro Assay;in vivo;Infection;insight;Instruction;Investigation;Knowledge;Life;Link;Malignant Neoplasms;medical schools;Mentors;Mentorship;Modeling;monocyte;mouse model;Mucous Membrane;Mus;Mutation;Organ;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral;peripheral blood;peripheral tolerance;Phenotype;Physicians;polarized cell;Population;Predisposition;primary immune regulatory disorders;Publishing;Regulatory T-Lymphocyte;research and development;Research Project Grants;response;responsible research conduct;restraint;Scientist;secondary lymphoid organ;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;STAT1 gene;STAT3 gain of function;STAT3 gene;symposium;Syndrome;System;T-Lymphocyte;Technical Expertise;Testing;therapeutic target;Training;Transgenic Mice;Universities;Variant;Virus;Virus Diseases;Washington;Work;Writing

PROJECT_TITLE: Mechanisms Contributing to T Cell Immune Dysregulation in STAT3 Gain-of-Function


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Hematology;Infectious Diseases;Sepsis

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Almost 100% of patients with septic shock—the most severe form of sepsis – have concurrent anemia; anemia in septic shock is often treated with blood transfusions when hemoglobin levels drop below 7.0 g/dL, but little is known about the effectiveness of this hemoglobin threshold-based blood transfusion strategy. The goals of this proposed research are to (1) examine practice pattern variation in threshold-based transfusion strategies in patients with septic shock across the United States, (2) identify patients with septic shock who are most, and least likely to benefit from threshold-based blood transfusion, and (3) pilot the implementation of an evidence- informed decision aid to improve and standardize transfusion practices during septic shock using a Learning Health Systems approach. Completion of this mentored career development proposal will be critical in informing septic shock clinical practice, guideline development, and future clinical trials and providing invaluable training in Learning Health System core competencies.

PI_NAMEs: BOSCH, NICHOLAS A (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute;Acute Lung Injury;Admission activity;Adoption;Advisory Committees;Anemia;Autologous;Benchmarking;Blood;Blood Transfusion;Boston;career development;Caring;Characteristics;Chronic Disease;Clinical;Clinical Data;clinical database;clinical implementation;clinical practice;Clinical Trials;clinically actionable;comparative effectiveness;Competence;Critical Care;Critical Illness;Data;Data Set;Databases;Decision Aid;Development;Development Plans;Drops;econometrics;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness study;effectiveness/implementation hybrid;Environment;Erythrocyte Transfusion;Erythrocytes;experience;Failure;Functional disorder;Future;Generations;Goals;Guidelines;Health system;Hematocrit procedure;Hemoglobin;Hemoglobin concentration result;Heterogeneity;Hospitalization;Hospitals;Hybrids;Immune response;improved;Individual;Infection;Inflammation;Intensive Care Units;Intervention;Knowledge;Leadership;Learning;Linear Models;Medical;Medical center;medical schools;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;Organ;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Pattern;Positioning Attribute;Practice Pattern Variations;Preparation;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Research Priority;Resistance;Resources;Risk;Risk Reduction;Sepsis;Septic Shock;skills;Standardization;State Hospitals;Techniques;Testing;Training;Transfusion;transfusion medicine;Translating;treatment effect;United States;Universities;Variant;Work

PROJECT_TITLE: A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Timely disposal of misfolded proteins is required to maintain a functional proteome and cellular health. Quality control pathways constantly monitor the proteome, promptly degrading proteins that do not fold properly or expose other degradation cues. The goal of this proposal is to elucidate how aberrant proteins are recognized in order to reveal universal mechanistic principles underlying quality control in different cellular organelles.

PI_NAMEs: PISA, RUDOLF  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Advisory Committees;aqueous;Architecture;Award;Binding;Biochemical;biochemical tools;Biochemistry;Biological;Biological Assay;career;Cells;Chemicals;Chemistry;Complex;Core Protein;crosslink;Cryoelectron Microscopy;Cues;Cytosol;design;Disulfides;Endoplasmic Reticulum;Endosomes;Environment;Equilibrium;Eukaryotic Cell;experience;experimental study;Exposure to;Glycoproteins;Goals;Golgi Apparatus;Health;hydrophilicity;Hydrophobicity;In Vitro;insight;Ion Channel;Lateral;Lipid Bilayers;Lipids;Mediating;medical schools;Membrane;Membrane Proteins;membrane reconstitution;Mentors;misfolded protein;Modeling;Monitor;multicatalytic endopeptidase complex;novel;Organelles;Pathway interactions;Peptide Signal Sequences;Phase;Positioning Attribute;Process;Protein Biosynthesis;protein degradation;protein oligomer;Protein translocation;Proteins;Proteome;proteostasis;Quality Control;reconstitution;Research Personnel;Resources;Saccharomyces cerevisiae;skills;structural biology;Structure;System;Testing;Thinness;Training;ubiquitin ligase;Ubiquitination;Visualization;Work;Yeasts

PROJECT_TITLE: Mechanistic and Structural Studies of ERAD

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (KR)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative The endoplasmic reticulum (ER) is a contiguous membrane-bound compartment, that extends to the periphery of neurons and forms contacts with other organelles to regulate organelle fission, calcium signaling and other important functions. Genes involved in maintenance of ER structure and ER contact sites are commonly found to be mutated in neurodegenerative disorders such as Hereditary Spastic Paraplegia. This proposal will investigate how ER structure and ER contact sites are regulated in neurons, and how mutations in genes linked to human disease lead to defects in ER interactions with other organelles.

PI_NAMEs: QUIÑONES-FRÍAS, MÓNICA CRISTINA (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;Binding;Biochemical;Biological;Biological Models;Calcium Signaling;Candidate Disease Gene;candidate identification;career development;Cell membrane;Cells;Cellular biology;Code;Complex;Cytoskeleton;Data;Defect;Development Plans;Disease;Drosophila genus;Electrophysiology (science);Endoplasmic Reticulum;endosome membrane;Endosomes;equity, diversity, and inclusion;Exhibits;experimental study;extracellular vesicles;follow-up;Foundations;Frequencies;Future;Genes;Genetic;Goals;Hereditary Spastic Paraplegia;Hippocampus;human disease;Image;Image Analysis;imaging approach;in vivo;Intracellular Membranes;knock-down;Label;Lead;light microscopy;Link;Lipids;Maintenance;Membrane;Membrane Fusion;Microscopy;Molecular;Morphology;mutant;Mutate;Mutation;Neurites;Neurodegenerative Disorders;Neuroglia;Neuromuscular Junction;Neurons;neurotransmission;optogenetics;Organelles;particle;Pathway interactions;Patients;Physiology;Play;Positioning Attribute;Postdoctoral Fellow;presynaptic;Presynaptic Terminals;Process;programs;Proteins;Publications;Reporter;Research;Research Personnel;response;Rest;restoration;retrograde transport;Role;Science;sensor;Shapes;Signal Transduction;Site;skills;Sorting;Structure;Synapses;Synaptic plasticity;System;Techniques;Testing;Time;trafficking;Training;ultra high resolution;Visualization;Work

PROJECT_TITLE: Role of Endoplasmic Reticulum Inter-Organelle Contacts in Neuronal Endosomal Traffic

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Orphan Drug;Rare Diseases

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Targeting the cholesterol supply by inhibiting NPC1-dependent endosomal cholesterol trafficking may be a potential strategy to treat cholesterol-addicted ccRCC tumors and overcome resistance to TKI-based therapeutic regimens. We anticipate that the proposed studies will gain insights that suggest new therapeutic options for the treatment of renal cancer.

PI_NAMEs: KOLENKO, VLADIMIR M (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Biological Markers;biomarker validation;cancer cell;cell growth;Cell membrane;Cells;Cessation of life;Chemotherapy and/or radiation;Cholesterol;cholesterol trafficking;Clear cell renal cell carcinoma;Clinical;clinical efficacy;clinically relevant;Data Analyses;Development;Disease;Endoplasmic Reticulum;Endosomes;Energy consumption;Ensure;Genetic;Growth;High Density Lipoproteins;Immunotherapeutic agent;Incidence;Individual;insight;Large Cell Carcinoma;LDL Cholesterol Lipoproteins;Link;Lipids;Lipoproteins;Low-Density Lipoproteins;Malignant Epithelial Cell;Malignant Neoplasms;Medical;Messenger RNA;Movement;neoplastic cell;new therapeutic target;Normal Cell;novel therapeutics;NPC1 gene;Outcome;Pathway interactions;Patient Selection;Patients;pharmacologic;Play;predictive marker;Prognosis;Prognostic Marker;Proliferating;Proteins;Radiation therapy;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Resistance;response;Role;Route;Source;Sterol O-Acyltransferase;System;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;therapeutic target;Time;trafficking;treatment optimization;tumor;tumorigenic;Tyrosine Kinase Inhibitor;uptake;Very low density lipoprotein

PROJECT_TITLE: NPC1 as a novel therapeutic target in ccRCC


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Early child development interventions in low-resource global settings usually include a focus on responsive caregiving or early learning and nutrition, and most evaluate the effects on short-term outcomes in early childhood. The proposed work will fill current research gaps by identifying mechanisms through which early interventions impact health and development outcomes, assessing whether these effects persist into adolescence, and estimating the potential impact of multicomponent interventions that target multiple prevalent risk factors in early life simultaneously. This work will contribute to the optimal design of interventions to improve health and development through childhood and adolescence in low-resource global settings.

PI_NAMEs: PITCHIK, HELEN OSBORNE (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 14 year old;6 year old;7 year old;Academic achievement;acute infection;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Age;arm;aspirate;Attention;Award;Bangladesh;behavioral health;Biostatistical Methods;California;caregiver education;Caregivers;caregiving;Child;Child Development;Child Health;Childhood;chronic infection;Cognition;cognitive development;Communicable Diseases;control trial;Data;design;Development;Diarrhea;Dietary Intervention;disorder prevention;early childhood;Early identification;Early Intervention;Economics;enteric infection;Epidemiologic Methods;Evaluation;experience;Exposure to;Faculty;follow-up;food security;Future;Goals;Health;High Prevalence;Home;Home environment;Household;Hygiene;improved;improved outcome;Individual;innovation;intergenerational;Intervention;intervention effect;Language Development;Learning;Life;Life Cycle Stages;literacy;Literature;Long-Term Effects;low and middle-income countries;Mediating;Mediation;Mediator;member;Mental Health;Mentors;Methodology;middle childhood;Motor;multi-component intervention;National Institute of Child Health and Human Development;novel;nutrition;nutritional supplementation;Outcome;peer;physical conditioning;Policies;Population;Population Intervention;Poverty;Prevalence;programs;Randomized, Controlled Trials;Reproducibility;Research;Resource-limited setting;Resources;Risk;Risk Factors;Rural;Sanitation;self esteem;Seminal;sex;sexual and reproductive health;sociodemographic group;Statistical Methods;therapy design;therapy development;Training;transition to adulthood;treatment arm;Universities;Visit;Water;Work

PROJECT_TITLE: Evaluating multicomponent interventions to optimize health and development for children and adolescents living in poverty


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Among the more than five million people who suffer a moderate or severe traumatic brain injury each year, it is not currently possible to predict who will recover and who will remain functionally dependent on caregivers. Though advanced imaging now enables precise in vivo localization of brain injuries, it is not known whether dependency results from disruption of specific neural structures or networks. Dr. Snider’s proposal combines retrospective big data analysis with prospective independent validation to identify the neuroanatomical location of brain injuries that produce dependency, an approach with outstanding potential to improve prognostic accuracy and inform the design of targeted therapeutics.

PI_NAMEs: SNIDER, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Acute Brain Injuries;Address;Affect;Algorithms;Anatomy;Area;axon injury;Big Data;Biological;Brain;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Brain region;Career Choice;career development;Caregiver Burden;Caregivers;Caring;Cause of Death;Clinical;Clinical Data;clinical practice;Clinical Trials;cohort;Collaborations;Contusions;Data;Data Analyses;Data Collection;data harmonization;Data Set;Dependence;design;Development;Development Plans;Diffusion Magnetic Resonance Imaging;Disparate;Enrollment;Environment;Europe;Evaluation;experience;Focal Brain Injuries;Functional dependence;Functional impairment;Functional Magnetic Resonance Imaging;Goals;Health Expenditures;Hemorrhage;Heterogeneity;Hospitals;Image;imaging modality;imaging study;Imaging Techniques;improved;in vivo;injured;Injury;insight;International;Knowledge;Label;life-sustaining therapy;Linear Models;Link;Location;Magnetic Resonance Imaging;Maps;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modality;Modeling;multidisciplinary;multimodal neuroimaging;neural;Neuroanatomy;neuroimaging;Neurologist;novel;Outcome;outcome prediction;Pathology;Patient-Focused Outcomes;Patients;Persons;Positioning Attribute;premature;Principal Investigator;Prognosis;prognostic;prognostic model;prognostic significance;prognostication;programs;prospective;Quality of life;Recommendation;Recovery;Research;Research Personnel;Resources;Rest;Sampling;Severities;skills;Source;Structure;targeted treatment;Testing;tool;Training;Translating;Traumatic Brain Injury;United States National Institutes of Health;Validation;Withdrawal;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Dependency after Traumatic Brain Injury

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative New approaches for colon cancer treatments are needed to improve patient outcomes, particularly in advanced stage disease. In this study, we propose to investigate the potential of mucosal-associated invariant T (MAIT) cells to activate anti-tumor immunity and their potential as a therapeutic approach that could be combined with checkpoint therapy to combat colon cancer.

PI_NAMEs: BESWICK, ELLEN J.;LEUNG, DANIEL TED (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;anti-PD-1;antitumor effect;Antitumor Response;Cancer cell line;cancer diagnosis;cancer immunotherapy;cancer therapy;cell killing;Cell Line;Cells;checkpoint therapy;chemokine;colon cancer treatment;Colon Carcinoma;Colonic Neoplasms;combat;Coupled;CXCL10 gene;cytotoxic;cytotoxicity;Data;Diagnosis;Disease;exhaustion;Experimental Designs;Experimental Models;Granzyme;Human;human model;Immune;immune checkpoint blockade;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;in vivo;Injections;Innate Immune Response;Ligands;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;MC38;men;microbial;Microsatellite Instability;migration;Modeling;mortality;mouse model;Mucous Membrane;Mus;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Organoids;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 inhibitors;pre-clinical;Pre-Clinical Model;preservation;prevent;RANTES;recruit;Resected;response;T cell therapy;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic evaluation;Translations;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Woman

PROJECT_TITLE: MAIT cells as a therapeutic approach for gastrointestinal cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (J1)]


ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Proper development of the left and right sides of our bodies is critical for the correct positioning of our organs. Perturbations in this process result in heterotaxy, which is typically associated with congenital heart malformations and high lethality in the first year of life. This study investigates the evolutionary and developmental mechanisms that establish left-right asymmetry, using veiled chameleons as a research organism, and has the potential to discover novel and conserved processes, and advance the diagnostic outcomes for heterotaxy and congenital heart disease patients.

PI_NAMEs: SHYLO, NATALIA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Automobile Driving;Biological Process;Birds;Calcium Oscillations;career;Cell Culture Techniques;cell motility;Cells;Chick Embryo;Chickens;Cilia;cilium motility;Computational Biology;congenital heart abnormality;CRISPR/Cas technology;Data Analyses;Death Rate;Development;Developmental Process;Diagnostic;egg;Embryo;embryo culture;Ensure;Evaluation;Event;Evolution;Foundations;Future;Gastrula;gastrulation;Gene Expression;Genes;Genetic;Genome;genome annotation;genome sequencing;Goals;Guide RNA;Human;Image;Individual;Injections;insight;Jaw;knockout gene;Lateral;Lead;Left;Libraries;Life;Light;Mammals;Mechanics;Mediating;Mesoderm;Microinjections;Microscopy;Modeling;Molecular;molecular asymmetry;Morphogenesis;Morphology;mortality;Motility;Movement;Mus;Mutation;Nodal;novel;Operative Surgical Procedures;Organ;Organism;Organogenesis;Outcome;Oviposition;paralogous gene;Pathway interactions;Patients;Pattern;Positioning Attribute;Process;Production;Proteins;Pump;Recombinant Proteins;Reporter;Reptiles;Research;Role;Side;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Situs Inversus;success;Techniques;temporal measurement;Tetrapoda;Thinking;Tissues;Training;Ungulate;Vertebrates;Viral;Virus;Work;zygote

PROJECT_TITLE: Evolutionary mechanisms of gastrulation and left-right patterning in amniotes.

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Clinical evidence suggests that the cerebellum plays key roles in cognitive and social behaviors, but a circuit- level understanding of how it performs non-motor computations is lacking. The proposed research will apply sophisticated neural recording and control techniques to determine how cerebellar Purkinje neurons contribute to reward learning. This research program will define non-motor computations in the cerebellum, a critical prerequisite to isolating cerebellar disruptions that underlie cognitive impairments in neurological disorders.

PI_NAMEs: WANG, YILIU  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TITLE: Defining cerebellar computation and function during associative learning with two-photon optogenetics

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Preterm birth is a major risk for neonatal mortality and long-term child health problems, including motor and mental developmental delays and chronic illness. Knowledge of the stressful contexts in which Black women live and the biolocal pathways through which stress affects preterm birth, will increase our understanding of why some women have poor pregnancy outcomes. These findings will generate new perspectives for future research, inform new lines of inquiry regarding the pathways will contribute to the development of culturally appropriate interventions to reduce racial disparities in preterm birth and ultimately improve birth outcomes.

PI_NAMEs: NOWAK, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: 37 weeks gestation;Affect;Anti-Inflammatory Agents;Archives;Award;Binding;Biological;biological adaptation to stress;biopsychosocial;Birth;Birth Rate;Black Populations;Black race;black women;Blood specimen;Candidate Disease Gene;career;Censuses;Child Health;Chinese;Chronic Disease;Chronic stress;cohort;Complex;Crime;culturally appropriate intervention;Data;Data Set;Development;Developmental Delay Disorders;Disease;DNA;DNA Integration;DNA Methylation;Enrollment;environmental stressor;epigenetic aging;epigenome;Equilibrium;Equity;Exhibits;experience;Fostering;gene environment interaction;Gene Expression;Genes;Genotype;Gestational Age;Glucocorticoids;Goals;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immunity;Immunosuppression;improved;Inequity;Infant;Infant Mortality;Inflammation;Inflammatory;insight;Intervention;K-Series Research Career Programs;Knowledge;Koreans;Link;low socioeconomic status;Mediating;Methods;Migration Inhibitory Factor;Modification;Motor;neighborhood association;neighborhood disadvantage;Neighborhoods;Neonatal Mortality;Not Hispanic or Latino;Outcome;Pathway interactions;Pattern;perceived stress;Phenotype;physical conditioning;Plasma;Pregnancy;Pregnancy Maintenance;Pregnancy Outcome;Pregnant Women;Premature Birth;Premature Infant;Psyche structure;Psychological Stress;psychosocial;racial disparity;Regulation;Reporting;response;Risk;Sampling;Single Nucleotide Polymorphism;Site;social factors;social stressor;sociodemographics;Stress;stressor;Syndrome;Term Birth;Training;Variant;White Women;Woman;Work

PROJECT_TITLE: An Integrated Omics Approach to Neighborhood Disadvantage and Preterm Birth in Black Women


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Infectious Diseases;Liver Disease;Sepsis

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE This project aims to investigate the role of C/EBPβ-mediated loss of liver function in sepsis associated ACLF and to find the link between sepsis induced endothelial dysfunction and C/EBPβ activation. Using mouse models and human liver transplant explants we will study the role of C/EBPβ-induced hepatocyte dedifferentiation and investigate potential therapeutic targets.

PI_NAMEs: TIKHANOVICH, IRINA  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Acute Liver Failure;Acute-Phase Reaction;Albumins;Angiopoietin-2;Angiopoietins;ANGPT1 gene;Animal Model;Binding;Body System;Cell Cycle Progression;Cell Death;Cell Proliferation;chromatin immunoprecipitation;Chromatin Modeling;Chronic;Cirrhosis;Clinical;cofactor;Data;Differentiated Gene;Differentiation Antigens;Endothelial Cells;endothelial dysfunction;Event;experimental study;Extracellular Matrix;Failure;Future;Gene Expression;Genetic Transcription;Hepatocyte;Human;Immune response;in vivo;Injury;Insulin-Like Growth-Factor-Binding Proteins;Knock-out;Link;Liver;liver development;Liver Failure;Liver Fibrosis;liver function;liver injury;Liver Regeneration;liver transplantation;Matrix Metalloproteinases;Mediating;Mediator;Metabolic;Modeling;mortality;mouse model;Mus;new therapeutic target;novel;Pathogenesis;Patients;Phenotype;Post-Translational Protein Processing;prevent;Production;Proliferating;Protein Isoforms;Regenerative response;Role;Sampling;Sepsis;Signal Transduction;Specificity;Syndrome;therapeutic target;transcription factor

PROJECT_TITLE: The role of C/EBPß in sepsis associated acute-on-chronic liver failure

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Aging;Bioengineering;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HADLEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE  This proposal aims to tailor design one high-precision optogenetic probing system, based on monolithic integration of close-packed dual-color LEDs and MEA, to dissect inter-region communication within regionalized organoid disease models. Specifically, we will investigate if our probes with scalable pixel counts/pitches could advance organoid disease modeling via tissue-level optogenetic electrophysiology. If successful, our technology will enable high-precision bi-directional optogenetic control of inter-region circuits and electrophysiology across multiple regions and depths of the organoids, which cannot be achieved by existing RNA sequencing, 3D organoid electro-physiology, or cell imaging methods.

PI_NAMEs: XU, GUANGYU  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;autism spectrum disorder;Brain;Caliber;cell type;Cells;cellular imaging;Color;Communication;Communities;Comparative Study;Consensus;Control Groups;design;Development;Disease;disease model;Electronics;Electrophysiology (science);flexibility;Gene Expression;Human;human disease;human stem cells;imaging modality;improved;insight;Intellectual functioning disability;Interneurons;Light;Maps;Mental disorders;Methods;Microelectrodes;migration;miniaturize;Modeling;Neurodevelopmental Disorder;neuroregulation;Optics;optogenetics;Organ;organoid transplantation;Organoids;Outcomes Research;Output;Pathway interactions;Pattern;Phenotype;Prosencephalon;Research;Resolution;Schizophrenia;screening;Signal Pathway;Source;spatiotemporal;Specificity;spheroids;Stimulus;Structure;System;Technology;Thalamic structure;Therapeutic;three dimensional structure;Tissue Engineering;Tissues;tool;transcriptome sequencing;Work

PROJECT_TITLE: Dissecting inter-region communication in human organoid models with dual-color optogenetic probes

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Genetics;Liver Disease;Neurodegenerative;Neurosciences;Nutrition;Pediatric;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative In this proposal, we explore the hypothesis that inhibition of the mammalian Target of Rapamycin (mTOR) promotes a shift in nutrient metabolism away from the utilization of carbohydrates and toward the burning of fats in mitochondrial disorders caused by dysfunction of Complex I of the Electron Transport Chain. We hypothesize that this shift, mediated by two proteins called Sirt3 and C/EBP-β, suppresses symptoms of disease and improves survival. This project will determine the role of nutrient metabolism in the onset and treatment of neurological mitochondrial disorders.

PI_NAMEs: BITTO, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;adefovir dipivoxil;Adipose tissue;Affect;Amino Acids;Animals;Body fat;Brain;Caloric Restriction;Carbohydrates;Catabolism;Cells;Cerebrum;Childhood;cohort;Complex;Cues;Deacetylase;Deacetylation;Degenerative Disorder;Dependence;Development;Disease;disease phenotype;Disease Progression;Disorder of neurometabolic regulation;Encephalopathies;Endocrine;enhancer binding protein;Enzymes;Etiology;extend lifespan;fat burning;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Foundations;FRAP1 gene;Functional disorder;Gene Expression;Genetic;Glycolysis;Growth;Growth Factor;Hepatic;Homeostasis;improved;inhibitor;insight;Intervention;Investigation;Knock-out;Lactic Acidosis;Leigh Disease;Lethargies;Life;life span;Lipids;Live Birth;Liver;liver function;loss of function;Mediating;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Encephalomyopathies;mitochondrial metabolism;Modeling;Motor Skills;mouse model;Mus;NADH dehydrogenase (ubiquinone);Nature;Neurologic;Neurologic Symptoms;Neuronal Dysfunction;Neurons;novel;novel therapeutic intervention;nucleoside analog;Nutrient;nutrient metabolism;Onset of illness;oxidation;Patients;pharmacologic;Phenotype;preference;Prognosis;Proteins;response;Reverse Transcriptase Inhibitors;Role;Severity of illness;Signal Transduction;Sirolimus;Sirtuins;stroke patient;Symptoms;Testing;transcription factor;Transgenic Mice

PROJECT_TITLE: Metabolic treatment of neurological mitochondrial disorders

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Project Narrative Understanding the functional and structural roles of microbial communities at the single-cell level is critical for unraveling the interrelationships between members of a microbial community and with host tissue. This project aims to establish a single-cell functional paradigm by measuring microbial adhesion forces within microbial community. Through an innovative combination of expansion microscopy and multiplex PNA FISH imaging, we will explore the functional aspects of microbial communities beyond their spatial arrangement, and globally analyze microbial interactions at the micron level.

PI_NAMEs: DONG, PU-TING  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Adhesions;Adhesives;Affinity;Aftercare;Attention;Award;Bacterial Adhesion;Binding;Biological;Biotin;Calibration;career;Cells;cellular imaging;Chronic;combinatorial;Communities;Complex;Corynebacterium;crosslink;Crowding;Dental Plaque;Dissection;DNA;DNA sequencing;Electrostatics;Enzymes;experimental study;Fluorescent in Situ Hybridization;Fostering;Fusobacterium nucleatum;Gel;Goals;Growth;Health;Human;human disease;Image;In Vitro;Individual;innovation;insight;Ionic Strengths;Label;Link;Measurement;Measures;member;Methodology;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;microbiome research;microorganism interaction;Microscopy;Molecular;monomer;Mouth Diseases;nanoscale;next generation;Oligonucleotides;oral biofilm;Oral cavity;Oral health;oral microbial community;Oral Microbiology;oral microbiome;Organism;Peptide Nucleic Acids;Phenotype;Play;polymicrobial biofilm;Process;Productivity;Research;Resolution;Role;Sampling;Shapes;spectrograph;Streptavidin;Streptococcus gordonii;Streptococcus oralis;Streptococcus sanguis;superresolution imaging;Swelling;Taxonomy;Techniques;Technology;Thick;Tissues;tongue dorsum;tool;translational scientist;ultra high resolution;Variant;Veillonella parvula;Visualization;Water

PROJECT_TITLE: Differentiation of Microbe-microbe Interactions at Single-cell Level Through Unconventional Utilization of Expansion Microscopy

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Early life adversity (ELA) can produce lasting effects on brain development and behavior and can increase the risk for the development of substance use disorder (SUD). The proposed studies will provide new insights into mechanisms underlying stress and SUD-related behaviors. Understanding these mechanisms will advance the field and may lead to the development of novel therapeutics for SUD.

PI_NAMEs: CUARENTA, AMELIA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Adolescent;Adult;Adverse event;Affect;Amygdaloid structure;Astrocytes;Beds;Behavior;Behavioral;Brain;Cell Separation;cell type;comparison control;Data;Development;DNA;DNA Sequence;DNA Transposable Elements;early experience;early life adversity;early life stress;Elements;Environment;Environmental Impact;Epigenetic Process;Event;experimental study;Exposure to;Female;Foundations;Future;gene network;genetic approach;Genome;Genomics;Goals;Human Genome;Impulsive Behavior;Impulsivity;innovation;insight;Intercistronic Region;Intervention;knock-down;Knowledge;Learning;Length;Life;Lifestyle-related condition;Location;Long Interspersed Elements;Magnetism;male;Mediating;Mental disorders;Mentors;Modeling;Molecular Biology;Molecular Genetics;Morphine;Neonatal;Neuroendocrinology;Neuroglia;Neurons;neuropsychiatric disorder;Neurosciences;novel;novel therapeutics;Odors;Oligodendroglia;Paste substance;Pathway interactions;Pharmaceutical Preparations;Phase;Play;Poverty;programs;promote resilience;Rattus;Research;resilience;Resources;Retrotransposition;Retrotransposon;reward circuitry;Rewards;Risk;rodent genome;Role;Self Administration;Stress;Substance Use Disorder;substance use treatment;Techniques;Testing;therapy design;timeline;tool;Training

PROJECT_TITLE: Early resource scarcity effects on addiction-related behavior: a novel role for retrotransposons.

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Human Genome;Pain Research;Patient Safety

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Pharmacogenomics has the potential to improve medication safety in the treatment of chronic pain—which impacts an estimated 1 in 5 adults; however, testing is rarely ordered. Pain physicians are an understudied group of expert stakeholders. By examining their knowledge, views, and practices with pharmacogenomics, this study will improve our understanding of a) the barriers and facilitators to testing and b) clinical and ethical considerations to guide the use of pharmacogenomics in chronic pain care.

PI_NAMEs: HENDY, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Adopted;Adult;adverse drug reaction;Analgesics;Anthropology;anti-depressive agents;Award;barrier to care;Board Certification;Caring;chronic pain;chronic pain management;Clinical;clinical care;community engagement;Data;Dedications;design;Development;Disparity;Education;Educational Status;Equilibrium;ethical, legal, and social implication;Ethics;ethnographic method;Ethnography;Failure;Fellowship;Fellowship Program;Foundations;Genetic Risk;genome sciences;Genomic medicine;Genomics;Goals;Grant;Guidelines;health care settings;Immersion;Improve Access;improved;Individual;Individual Differences;innovation;Institution;Interview;Journals;K-Series Research Career Programs;Knowledge;Medical;medical specialties;Medication Management;medication safety;Medicine;Mentorship;Methodology;Methods;Michigan;Modeling;Non-Steroidal Anti-Inflammatory Agents;Observational Study;Opioid;Pain;Pain management;Pain Measurement;participant observation;Pathway interactions;patient oriented;Patients;Pharmaceutical Preparations;Pharmacogenomics;Pharmacologic Substance;Phase;Physicians;Positioning Attribute;Postdoctoral Fellow;Primary Care;programs;Publications;rapid growth;Research;Research Methodology;Research Project Grants;Risk;Safety;Sampling;Scholarship;Science;Scientist;Secure;Shapes;skills;Source;Surveys;symposium;System;Technology;tenure track;Testing;Time;Training;Training and Education;training project;trend;United States Food and Drug Administration;Universities;uptake

PROJECT_TITLE: Understanding barriers and facilitators to pharmacogenomic testing in chronic pain care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Alzheimer’s disease is a complex neurodegenerative disorder with overwhelming personal, societal, and economic burdens for which there is currently no means of prevention or disease-modifying treatments. In this proposal, I will use multi-omic analyses in observational and interventional studies of human and mouse models of AD to systematically characterize molecular pathways associated with Alzheimer’s genetic risk and resilience. Completing this proposal can identify causal genetic variants of Alzheimer’s disease that have not been previously resolved using traditional genetic approaches and prioritize genes and pathways for drug development.

PI_NAMEs: D'OLIVEIRA ALBANUS, RICARDO  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: AD transgenic mice;Address;Advisory Committees;Affect;Age;age effect;Age of Onset;age related;age-related disease;aged;Aging;aging related disease;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's Disease Pathway;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Autophagocytosis;Autopsy;Award;Bioinformatics;Biology of Aging;Biomedical Research;Brain;brain tissue;Caloric Restriction;career;causal variant;Cell Nucleus;cell type;Cells;Centenarian;Clinical;Cognition;Cognitive;cohort;Compensation;Complex;Computational Technique;Data Analyses;data integration;Development;Disease;drug development;Economic Burden;Educational workshop;effective therapy;epigenomics;experience;extend lifespan;Feedback;Foundations;FRAP1 gene;functional genomics;Future;Genes;Genetic;genetic approach;genetic association;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genets;genomic data;Goals;healthy aging;high risk;Human;human disease;Human Genetics;human model;human old age (65+);Impaired cognition;Individual;innovation;insight;Intervention;Intervention Studies;Knowledge;Leadership;life span;Longevity;longitudinal analysis;Mediating;Mentors;Mentorship;mimetics;Modernization;Molecular;Molecular Biology;Molecular Profiling;mouse model;Multiomic Data;multiple omics;Mus;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuropathology;novel;novel therapeutic intervention;Observational Study;Onset of illness;Pathology;Pathway interactions;Patients;Phase;Phenotype;Population;Prevalence;prevent;Prevention;Prevention strategy;Regulation;Reporting;Research;Research Design;resilience;resilience in aging;Resistance;Resolution;response;Risk;Risk Factors;Role;single nucleus RNA-sequencing;skill acquisition;skills;social;Solid;symposium;targeted treatment;Testing;Therapeutic;therapy development;Training;Training Programs;transcriptomics;Untranslated RNA;Variant

PROJECT_TITLE: Genetic and single-cell multi-omic characterization of Alzheimer's disease risk and resilience pathways

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Telehealth;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Latinas suffer more perioperative complications that their non-Hispanic peers when undergoing urogynecologic surgery, in part, because of lower surgical preparedness. Prior studies to increase surgical preparedness have been conducted mostly on White women, excluded non-English speakers, and not cost-effective nor practical. The proposed research will use human centered design and dissemination and implementation methods to center stakeholder input to develop a usable and sustainable intervention that considers the cultural and societal needs of Latina patients and their clinical environments, an approach not used thus far in the development and testing of other surgical preparedness interventions.

PI_NAMEs: HALDER, GABRIELA E. (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: access disparities;Address;Award;Behavior Therapy;career;career development;Clinical;Clinical Research;community based participatory research;community collaboration;cost effectiveness;Cross-Sectional Studies;Data;design;Development;Discover, Design, Build, and Test Framework;Dissemination and Implementation;dissemination science;Effectiveness;effectiveness clinical trial;effectiveness evaluation;Environment;Equity;Ethnic Population;evidence base;Exclusion;Female;Foundations;Funding;Future;Goals;Health;health equity;Health equity research;health inequalities;Health Services Accessibility;human centered design;implementation framework;implementation outcomes;implementation science;implementation strategy;improve minority health;improved;improved outcome;Intervention;Intervention Studies;Knowledge;Language;Latina;Latina Population;Leadership;Life;Literature;low health literacy;marginalized population;Measures;Medical;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Not Hispanic or Latino;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;patient oriented;Patients;peer;pelvic organ prolapse;Pelvis;Perioperative;Perioperative complication;Phase;pilot test;Positioning Attribute;preference;Principal Investigator;Procedures;Process;prototype;racial population;randomized, clinical trials;Readiness;Reduce health disparities;Research;Research Methodology;Research Personnel;Scientist;skills;Surgeon;surgical disparities;Surgical Management;Surgical Specialties;telehealth;Testing;Texas;therapy design;Training;treatment disparity;United States National Institutes of Health;Universities;Urinary Incontinence;usability;user centered design;White Women;Woman;Work

PROJECT_TITLE: A Telehealth Intervention to Increase Patient Preparedness for Surgery in Latinas

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Human Genome;Skin Cancer;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The level of mutations in the mitochondrial genome (mtDNA) increases with human tissue aging, offering a potential metric of aging and a novel target for intervention; however, the scope and functional consequences of these mutations remains unclear due to technical barriers. I will utilize a novel long-read sequencing method I developed and published to discover the tissue specific scope of age-associated mtDNA mutations, along with an induced pluripotent stem cell-based system I am developing, to directly test the relationship between age-induced mtDNA mutations and progenitor cell dysfunction. This work will provide an extraordinary, mentored career development experience and invaluable foundational knowledge for future work to understand the consequences of mtDNA changes in aging and to test data-driven interventions that mitigate these changes.

PI_NAMEs: VANDIVER, AMY R. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;age related;aged;Aging;aging brain;Award;Biological;Biology of Aging;Board Certification;Body System;career;career development;cell growth;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Cutaneous;Data;Deletion Mutation;Dermatology;Development;Disparate;effective intervention;Event;experience;face skin;Frequencies;Functional disorder;Future;Genetic;Genetic Variation;Genome;genomic variation;Genomics;Genotype;Growth;hallmarks of aging;heteroplasmy;Human;human induced pluripotent stem cells;human tissue;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Interdisciplinary Study;Intervention;keratinocyte;Knowledge;laser capture microdissection;Length;Link;Maps;member;Mentors;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial DNA mutation;mitochondrial genome;mitochondrial metabolism;Morbidity - disease rate;mortality;muscle aging;Mutagenesis;mutant;Mutation;Neoplasms;novel;Nuclear;Pattern;Phase;Phenotype;physician-scientist training program;Physicians;Predisposition;prevent;Process;Proliferating;Publishing;regenerative biology;Reporting;Research Personnel;Role;Sampling;Scientist;segregation;skills;Skin;Skin Aging;Skin Carcinoma;skin squamous cell carcinoma;Skin Tissue;Source;Specificity;Squamous cell carcinoma;stem cell aging;stem cells;System;Testing;Tissue Sample;Tissues;tumor;Variant;Work

PROJECT_TITLE: Understanding mitochondrial mutations that drive human tissue aging

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer is the second leading mortality in the world, while many different treatments exist including revolutionary immunotherapies, adverse events are frequent and response rates are limited. Basic, translational, and clinical studies defined a key role for the gut microbiota in affecting tumor progression and immunotherapy efficacy, but the underlying mechanism remains at early stage of investigation. The focus of this proposal is to delineate two novel pathways by which microbiota interacts with mammalian hosts to impact tumor growth, progression, or immunotherapy response, thus provoking novel opportunities for intervention.

PI_NAMEs: LYU, MENGZE  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Accounting;Address;Adverse event;Affect;Anatomy;Antibiotics;Antigens;Antitumor Response;Area;beneficial microorganism;Cancer Biology;Cancer Burden;Cancer Center;cancer immunotherapy;cancer risk;cancer therapy;career;career development;Career Mobility;CD4 Positive T Lymphocytes;Cell Communication;cell motility;Cell Shape;Cells;Cessation of life;Chemicals;chronic infection;Clinical Research;Collaborations;combat;Communication;Data;Development;Development Plans;Distal;Educational process of instructing;Enrollment;Environment;Exhibits;experimental study;Fostering;Genes;Genetic;Germ-Free;Gnotobiotic;Goals;Growth;gut microbiota;high standard;host microbiota;host-microbe interactions;Human;Immune response;Immune Tolerance;Immunity;Immunocompromised Host;Immunotherapy;Impairment;implantation;Infiltration;Inflammatory Bowel Diseases;Institution;instrument;Intervention;Intestines;Investigation;Laboratories;Ligands;Link;Liver X Receptor;Lymphocyte;Lymphoid Cell;Malignant Neoplasms;Medicine;Mentors;Mentorship;Microbe;Microbiology;microbiota;migration;Molecular;mortality;mouse model;multiple omics;Mus;Myeloid Cells;neoplasm immunotherapy;Newly Diagnosed;novel;Outcome;pathogen;Pathway interactions;patient derived xenograft model;Patients;PD-1 blockade;Phase;Production;Productivity;Publishing;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;Resources;response;Role;Shapes;single-cell RNA sequencing;Site;skills;Specialist;T-Lymphocyte;Techniques;Testing;Therapeutic Intervention;tool;Transgenic Mice;translational study;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;United States;Up-Regulation;Writing

PROJECT_TITLE: Defining novel mechanisms of microbiota in regulating anti-tumor responses

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Our research aims to elucidate the mechanisms underlying chaperonopathies, a group of rare muscle diseases with no known cure. By investigating the role of DNAJ proteins in these diseases, we aim to improve patient quality of life. Ultimately, our findings may serve as a basis for the development of novel treatments for a broader range of diseases related to protein misfolding. Page ____ Proposal Narrative

PI_NAMEs: INOUE, MICHIO  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;animal imaging;Binding Proteins;biobank;Biological;Biological Markers;Biotin;career;Cell Survival;Cells;Chaperone Gene;Client;Core Facility;Cultured Cells;Data;Dedications;Defect;Degenerative Disorder;Desmin;Development;Disease;Family;Fiber;Filament;Foundations;Functional disorder;Genes;Goals;Health;Heat shock proteins;Heat-Shock Proteins 70;Heat-Shock Response;Human;Image;improved;Individual;innovation;insight;Japan;knock-down;Knock-out;Label;Laboratories;Lasers;Lead;Ligase;Maintenance;Medical;Mentors;Mentorship;Methods;Microdissection;misfolded protein;Molecular Chaperones;mouse model;Mus;Muscle;Muscle Fibers;Muscle Weakness;Muscular Dystrophies;Mutant Strains Mice;Mutation;Myoblasts;Myopathy;network dysfunction;novel;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Play;polyglutamine;Positioning Attribute;Predisposition;Process;programs;protein aggregation;protein misfolding;Proteins;Proteomics;proteostasis;Quality Control;Quality of life;Reporting;Research;RNA Interference;Role;Scientist;single nucleus RNA-sequencing;Skeletal Muscle;Soleus Muscle;Specific qualifier value;Specificity;Stress;stressor;supportive environment;Testing;Therapeutic Intervention;therapeutic target;Tissues;transcriptome sequencing;United States;Universities;Validation;Washington

PROJECT_TITLE: Elucidating the Role of DNAJ Proteins in Muscle Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Children with Attention Deficit Hyperactivity Disorder (ADHD) are at substantially increased risk for long- term difficulties into adulthood, including academic underachievement, substance abuse, and criminal behavior. In an effort to improve these outcomes, we propose a Repetitive Transcranial Magnetic Stimulation (rTMS)-based intervention to stimulate brain circuits important in response inhibition and study target engagement in neurophysiologic and behavioral outcomes. Project success will provide rationale for designing a multi-center sham-controlled clinical trial to test clinical ADHD outcome in response to rTMS treatment.

PI_NAMEs: WU, STEVE WEI (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: 17 year old;Acceleration;Adolescent;Adult;Affect;Anatomy;Area;Attention deficit hyperactivity disorder;Behavior;behavior measurement;Behavioral;behavioral construct;behavioral outcome;behavioral response;Biological Markers;Brain;Brain region;Child;Childhood;Clinical;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive deficits;Combined Modality Therapy;Controlled Clinical Trials;criminal behavior;Data;density;design;Diagnosis;Disease;Dose;Electroencephalography;follow-up;Funding;High Prevalence;illicit drug use;Impairment;improved;improved outcome;indexing;Individual;innovation;inpatient psychiatric treatment;Intervention;Investigation;Link;meetings;Motor;Motor Cortex;Neurodevelopmental Disorder;Neuronavigation;neurophysiology;neuropsychiatric disorder;neuroregulation;Occupational;Outcome;Output;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiological;Physiology;Population;predicting response;Protocols documentation;psychosocial outcome;Publishing;Reaction Time;recruit;repetitive transcranial magnetic stimulation;Research;response;Risk;Role;Safety;Sampling;Severities;Signal Transduction;Site;Stimulant;Substance abuse problem;success;Symptoms;targeted biomarker;Techniques;Teenagers;Testing;Therapeutic;Therapeutic Effect;Training;Transcranial magnetic stimulation;treatment arm;Underachievement;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: ADHD PreSMART: ADHD PreSMA Response inhibition Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (02)]