NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Clinical Research;Kidney Disease;Organ Transplantation;Patient Safety;Transplantation

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Over the last 20 years, the number of older adults (aged≥55) undergoing live donor nephrectomy has increased 4-fold. In light of an aging US population, the new kidney transplant allocation system, and recent changes to Kidney Disease: Improving Global Outcomes (KDIGO) practice guidelines, this trend is likely to continue. The goal of this project is to improve our understanding of the perioperative and long-term risks most pertinent to older donors in order to inform dialogue with care providers.

PI_NAMEs: MUZAALE, ABIMEREKI D (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: adverse outcome;Affect;Age;age related;aged;Aging;aging population;aging related;attributable mortality;attributable risk;Biological Markers;bone metabolism;Cardiovascular Diseases;care providers;career;Characteristics;Clinical;clinical investigation;clinical phenotype;Code;Cognitive;cohort;Contrast Media;Data;data registry;Data Set;design;Diabetes Mellitus;Diagnosis;Diagnostic Procedure;disability;Doctor of Philosophy;Drug Prescriptions;End stage renal failure;Enrollment;epidemiology study;Event;Faculty;Fracture;functional outcomes;Funding;General Population;Goals;Grant;Guidelines;Health;high risk;Hospitalization;Hypertension;improved;Incidence;Individual;Information Sciences;Inpatients;Investigation;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Laboratories;Learning;learning strategy;Light;Link;living kidney donor;Logistic Regressions;Medical;Mentorship;Minerals;mortality;mortality risk;Multicenter Studies;National Health and Nutrition Examination Survey;Nephrectomy;Nephrons;novel;older adult;Older Population;Operative Surgical Procedures;Organ Transplantation;Outcome;Patients;Perioperative;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;Population;Postdoctoral Fellow;Practice Guidelines;predictive tools;Predisposition;Prevalence;Principal Investigator;programs;Provider;Publishing;Quality of life;Research;resilience;Resources;response;Risk;Sampling;Science;senescence;Sentinel;Source;Specific qualifier value;Stress;System;Testing;Training;Transplantation;trend;Universities;Work

PROJECT_TITLE: Perioperative and long-term risks following nephrectomy in older live kidney donors


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  The innate immune system can sense nucleotide ligands associated with pathogen infection, but when this sensing is not controlled correctly it can trigger autoimmune pathology driven by endogenous ligands. This work investigates the role of the sensor ZBP1 autoimmune pathology in a model of human autoimmune disease.

PI_NAMEs: OBERST, ANDREW ATWELL (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Ablation;ADAR1;Adenosine;Amino Acid Substitution;Animal Model;antiviral immunity;Apoptosis;Attenuated;attenuation;Autoimmune;Autoimmune Diseases;Autoimmunity;autoinflammatory;autoinflammatory diseases;base;Binding;Cell Death;Cell Line;Cells;Cessation of life;clinical development;Data;Deamination;DNA;DNA Binding Domain;Double-Stranded RNA;Enzymes;Generations;Genetic;Genetic study;Genetic Transcription;Goals;Host Defense;Human;human model;Immune;Immunity;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Innate Immune System;Inosine;insight;Investigation;Lead;Ligand Binding Domain;Ligands;Ligation;loss of function;loss of function mutation;Mediating;Modeling;mouse model;Mus;Mutation;Nucleic Acids;Nucleotides;Output;pathogen;pathogenic virus;Pathogenicity;Pathology;Pathway interactions;Patients;Phosphotransferases;Physiological;Point Mutation;premature;prevent;Process;Protein Kinase Interaction;Proteins;pseudotoxoplasmosis syndrome;Receptor Activation;Receptor-Interacting Protein;Research Personnel;response;Ribonucleoproteins;RNA;RNA Binding;RNA Editing;RNA Virus Infections;Role;sensor;Signal Transduction;Source;Sterility;Syndrome;Testing;TNF gene;tool;Tumor Necrosis Factor Receptor;Viral;Virus;Virus Diseases;Work;Z-DNA Binding Protein;Z-Form DNA

PROJECT_TITLE: ZBP1 activation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Rare Diseases

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE: Our research focuses on the kinases and phosphatases targeting RNA polymerase II and transcripton. Malfunction of RNA polymerase II phosphorylation leads to cell death, developmental defects, and cancer. We use chemical and analytic biology to investigate and modulate this process.

PI_NAMEs: ZHANG, YAN JESSIE (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemistry;Biological;Biology;C-terminal;Cell Death;Cells;Chemicals;Defect;design;Development;DNA Polymerase II;Eukaryota;Event;experience;Genetic Transcription;Glioblastoma;Growth;Human;inhibitor;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methodology;Methods;Modification;Molecular;multidisciplinary;Outcome;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Process;Protein Chemistry;Proteins;recruit;Research;RNA Polymerase II;RNA polymerase II largest subunit;Specificity;structural biology;transcription factor;Transcription Process;transcriptome

PROJECT_TITLE: Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcription


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Most of the over 40,000 patients diagnosed with pancreatic cancer each year in this country will die from metastatic disease. Irreversible electroporation (IRE) is a non-thermal ablation technique that is currently being used clinically to treat locally advanced tumors. The goal of this research is to understand effects of IRE on the immune system and to augment these effects using immunotherapy agents to eradicate distant micrometastatic disease.

PI_NAMEs: WHITE, REBEKAH  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Ablation;Abscopal effect;adaptive immune response;Adjuvant;Adjuvant Therapy;advanced pancreatic cancer;Agonist;anti-tumor immune response;Antibodies;antigen-specific T cells;Biology;cancer immunotherapy;candidate identification;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;checkpoint inhibition;Cicatrix;Clinical;clinical care;Clinical Trials;clinically relevant;Combined Modality Therapy;Contralateral;Country;Data;Dendritic Cells;design;Diagnosis;Disease;Distant;DNA delivery;Effector Cell;Electroporation;Fibrosis;Future;Goals;Human;Immune;immune cell infiltrate;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;Immunodeficient Mouse;Immunologic Adjuvants;Immunotherapeutic agent;Immunotherapy;Implant;improved;in situ vaccine;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;Invaded;irradiation;Laboratories;Localized Disease;Malignant neoplasm of pancreas;Metastatic Neoplasm to the Liver;Methods;Modeling;mouse model;multidisciplinary;Mus;neoantigens;Neoplasm Metastasis;new growth;novel;Operative Surgical Procedures;Organoids;pancreatic cancer model;pancreatic cancer patients;Patient Care;patient derived xenograft model;Patient-Focused Outcomes;Patients;pre-clinical;Pre-Clinical Model;prevent;prophylactic;Proteins;Radiation therapy;reconstitution;Recurrence;Research;response;RNA;Specimen;subcutaneous;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Therapeutic;TLR7 gene;TNFRSF5 gene;Toll-like receptors;treatment response;tumor;tumor ablation;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;voltage

PROJECT_TITLE: Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Kidney Disease;Liver Disease;Organ Transplantation;Prevention;Transplantation

PHR: Due to epidemics of opioid overdose and hepatitis C virus (HCV), organs from HCV+ donors are increasingly available, however thousands are currently discarded that could benefit individuals in need of a transplant. A new practice of transplanting HCV+ donor organs into individuals without HCV, in combination with HCV medications, has shown early success. This proposal includes a trial of HCV+ donor kidney transplantation in order to determine the best timing and duration of HCV medications, and scientific studies that will improve our understanding of HCV infection and immune responses, as well as novel viruses.

PI_NAMEs: DURAND, CHRISTINE MARIE (contact);SEGEV, DORRY L.

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: 2019-nCoV;Acute;Acute Hepatitis C;acute liver injury;Adoption;Aftercare;Age;Agreement;Alanine Transaminase;American;Anti-viral Agents;arm;Biology;Biometry;BK Virus;Blood;Cells;Cessation of life;Cholestasis;Clinical;clinical practice;Clinical Research;clinical risk;co-infection;Collaborations;Communicable Diseases;cytokine;Cytomegalovirus;Data;Data Collection;data management;donor-specific antibody;Dose;emerging virus;Enrollment;Ensure;epidemic virus;Epidemiology;epidemiology study;Equipoise;Event;experience;Failure;Fibrosis;Genetic;Genetic Polymorphism;Graft Survival;Health;Hepatitis;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Hepatocyte;Hour;IL18 gene;Immune;immune activation;Immune response;Immunocompromised Host;Immunologics;Immunology;improved;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Infrastructure;Innate Immune Response;innovation;insight;Interleukin-1;intrahepatic;Kidney;Kidney Transplantation;Knowledge;laser capture microdissection;Life;Link;Liver;liver biopsy;liver injury;Measures;Mediating;Monitor;multidisciplinary;Nephrology;Nested Case-Control Study;novel virus;Oncology;operation;Opioid;opioid epidemic;opioid overdose;Organ;Organ Donor;Organ Transplantation;Outcome;Pathology;Perfusion;Pharmaceutical Preparations;Phylogenetic Analysis;Plasma;post-transplant;prevent;Primary Infection;primary outcome;Prophylactic treatment;Race;Randomized;Randomized, Controlled Trials;Reporting;Resistance;Safety;sample collection;secondary endpoint;sex;Shapes;Standardization;Subgroup;success;Testing;transcriptome;transmission process;transplant centers;Transplant Recipients;Transplantation;Transplantation Surgery;Treatment Failure;trial comparing;Uncertainty;vaccine development;Vaccines;Viral;viral RNA;viral transmission;Viremia;virology;virome;Virus Diseases;Virus Replication

PROJECT_TITLE: A Randomized Controlled Trial of Prophylaxis with Direct-acting Antivirals for Kidney Transplantation from Hepatitis C virus-infected donor to Uninfected Recipients (PREVENT-HCV)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: The proposed project will address a gap in knowledge regarding Alzheimer’s disease and related dementias (ADRD) investigators’ data sharing practices, perceptions of policies, and navigation of barriers. Despite demonstrated benefits of data sharing in the health sciences - prior data shows suboptimal data sharing practices (e.g., data withholding, misuse of data, and inequity in sharing). An increased understanding of factors that facilitate or impede data sharing will support interventions that enable broad data sharing practices and will advance therapeutic discoveries in ADRD.

PI_NAMEs: ARIAS, JALAYNE J (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;Affect;Alzheimer's disease related dementia;Behavior;Biological Markers;Biological Sciences;career;Clinical;Clinical Trials;Data;Data Analyses;data management;data repository;data sharing;design;Disadvantaged;Disease;effective intervention;Empirical Research;equity, diversity, and inclusion;Ethical Review;Exclusion;experience;Generations;Genetic;Genetic Research;Goals;Guidelines;Health Sciences;Image;improved;Incentives;Individual;Inequity;innovation;Institution;Institutional Policy;Intervention;Interview;Journals;K-Series Research Career Programs;Knowledge;large datasets;Laws;Lead;Literature;Methods;minority investigator;multidisciplinary;Neurology;Neurosciences;Outcome;Ownership;Perception;Policies;Population;Predictive Factor;Prevalence;prevent;Professional Organizations;Qualifying;Recommendation;Reporting;repository;Research;Research Personnel;Resource-limited setting;Resources;Risk;Sampling;Scientist;Structure;Surveys;system-level barriers;Technology;Therapeutic;Therapeutic Research;therapy development;Thinking;Time;tool;Training;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Identifying barriers to optimizing data sharing and accelerate discovery in Alzheimer’s disease and related dementia research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Adeno-associated viral (AAV) mediated gene therapy is an approach for delivering genes to treat genetic diseases including hemophilia, an X-linked bleeding disorder. Recent studies show that a large portion of the AAV vector DNA is rearranged before and/or after delivery into the target cell/animal model which reduces the long-term effectiveness of the therapy, and vector genomes can become integrated in host cells with risk of genotoxicity. The goal of this project is to determine the nature of these rearrangements over time and in different animals or tissues and to identify strategies to prevent these changes in the DNA from occurring to improve AAV gene therapy efficacy and safety.

PI_NAMEs: BUSHMAN, FREDERIC D;SABATINO, DENISE E (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Animal Model;Animals;Attention;Base Sequence;Biology;Blood Coagulation Disorders;Canis familiaris;Capsid;CD8-Positive T-Lymphocytes;cell growth;Cells;clinical development;Clonal Expansion;Data;deep sequencing;Dependovirus;design;DNA;DNA Integration;DNA Repair;DNA Repair Pathway;DNA Structure;dog genome;Dose;Effectiveness;Event;experience;F8 gene;Factor VIII;Fatal Outcome;Frequencies;gene correction;Gene Delivery;Gene Modified;gene product;Gene Rearrangement;gene therapy;Gene therapy trial;Genes;Genetic Diseases;Genome;genome integrity;Genomics;genotoxicity;Goals;Hemophilia A;Hepatotoxicity;Holliday Junction Resolvases;homologous recombination;Human;Immune response;improved;Insertional Mutagenesis;Integration Host Factors;Inverted Repeat Sequences;Inverted Terminal Repeat;Link;Literature;Liver;Longitudinal Studies;Malignant Neoplasms;Mediating;Methods;MicroRNAs;Modeling;Nature;next generation sequencing;Nonhomologous DNA End Joining;novel;novel strategies;nuclease;Outcome;Output;particle;Pathway interactions;preservation;prevent;Production;Proteins;Reaction;repaired;Reporting;Risk;Risk Reduction;Safety;Sampling;Sequence Analysis;small hairpin RNA;Small Interfering RNA;small molecule;small molecule inhibitor;Structure;Therapeutic;therapeutic gene;Time;Tissues;Toxic effect;transduction efficiency;transgene expression;Transgenes;Treatment Efficacy;Validation;vector;vector genome;Viral;viral DNA;Viral Genome;Work

PROJECT_TITLE: Preserving Genome Integrity In AAV-Mediated Gene Therapy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Hematology;Human Genome;Neurosciences;Pediatric;Rare Diseases;Stroke

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder characterized by multifocal arteriovenous malformations (AVMs) that impair brain and other organ functions. There is currently no preventative treatment or cure for HHT or AVMs in general, but success of the proposed work will establish a robust preclinical animal model for HHT and AVMs and identify causal events for disease progression. Our findings will greatly advance the understanding of the molecular mechanisms of HHT pathogenesis and aid in the development of new therapeutic strategies that will impact future clinical practice for HHT and AVM patients.

PI_NAMEs: WANG, RONG  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Activin Receptor;Alleles;Animal Model;Arteries;Arteriovenous malformation;autosome;base;Bioinformatics;bioinformatics tool;Blood;Blood capillaries;Blood Vessels;bone morphogenetic protein receptors;Brain;brain arteriovenous malformations;brain dysfunction;brain endothelial cell;Brain imaging;Candidate Disease Gene;Categories;Cephalic;Cerebral endothelium;Characteristics;Clinical;clinical practice;Dangerousness;Data;Defect;Development;Disease;disease model;Disease Progression;Dominant Genetic Conditions;drug candidate;Endothelial Cells;Endothelium;Etiology;Event;Expression Profiling;Functional disorder;Future;Gene Expression Profile;Genes;genetic association;Genetic Diseases;Genetic Transcription;genome-wide;Genomics;Germ Lines;Goals;Hemorrhage;Hereditary hemorrhagic telangiectasia;Heterozygote;Histopathology;Human;Hypoxia;Image;Immunofluorescence Immunologic;In Situ;Inflammation;Inherited;innovation;Intervention;Intracranial Hemorrhages;Knock-out;Knowledge;Lesion;Ligands;LoxP-flanked allele;Mediator;Mesenchymal;Modeling;Molecular;mouse model;Mus;Mutation;neurobehavioral;Neurologic;new therapeutic target;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathology;Patients;Pattern;Penetration;Perfusion;Physiologic arteriovenous anastomosis;postnatal;pre-clinical;Pre-Clinical Model;Preventive treatment;Process;Production;rational design;Research;Resolution;Retina;ribosome profiling;Scientific Advances and Accomplishments;Shunt Device;Signal Transduction;Structure;success;Superoxides;Techniques;Telangiectasis;Therapeutic;therapeutic candidate;Time;transcriptome;Transforming Growth Factor beta;two-photon;Veins;Work

PROJECT_TITLE: Molecular Pathogenesis of Hereditary Hemorrhagic Telangiectasia

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative In this project we will develop quantitative criteria to identify patients who need additional drug treatment after surgery for kidney cancer. This treatment is expected to delay or avoid disease recurrence, however because of its toxic side effects only patients who are at high risk of cancer recurrence should be treated. Here we propose to develop better criteria for selecting the right patients for treatment after kidney cancer surgery.

PI_NAMEs: KNUDSEN, BEATRICE S (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adipose tissue;Adjuvant;Adjuvant Therapy;Algorithms;anti-PD-L1 antibodies;Architecture;Biological Markers;biomarker development;Blood Vessels;cancer biomarkers;cancer diagnosis;Cancer Prognosis;cancer recurrence;cancer surgery;cancer type;Cellular Morphology;Classification;Clear Cell;Clear cell renal cell carcinoma;Clinical;Clinical Practice Guideline;Clinical Trials;cohort;computer generated;convolutional neural network;Correlation Studies;Data;Detection;Diagnosis;digital;Disease Progression;Disease-Free Survival;draining lymph node;experience;Fatty acid glycerol esters;Funding;Future;Grant;Growth;Guidelines;high risk;High-Risk Cancer;Histologic;Histology;Immunotherapy;improved;innovation;Invaded;kidney surgery;large datasets;Machine Learning;Malignant Neoplasms;Manuals;Maps;Metastatic Neoplasm to Lymph Nodes;Modeling;Morphology;National Comprehensive Cancer Network;Necrosis;Nephrectomy;novel;Nuclear Grade;Operative Surgical Procedures;Pathologic;Pathologist;Pathology;pathology imaging;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Performance;performance tests;Pharmacotherapy;Phase III Clinical Trials;Practice Guidelines;predictive marker;predictive modeling;Probability;Prognosis;prognostic;prognostic assays;Prognostic Marker;prognostication;random forest;Recommendation;Recurrence;Recurrent disease;Recurrent tumor;Regional Cancer;Renal Carcinoma;Renal Cell Carcinoma;Risk;Risk Assessment;risk stratification;Selection Criteria;side effect;Slide;Source;Staging;Stratification;Systemic Therapy;Testing;The Cancer Genome Atlas;Thrombus;tissue biomarkers;Tissue imaging;Tissues;Training;tumor;Tumor Cell Invasion;Tumor Expansion;tumor growth;tumor progression;Tumor stage;Tumor Tissue;Universities;Utah;Venous;Work

PROJECT_TITLE: Pathomics biomarkers for stratification of clear cell kidney cancers


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Bacteria that cause infections in humans exploit human cellular factors to promote disease. We propose to investigate how human factors that are used by Shigella, a bacterium that causes severe diarrhea, contribute to disease. Understanding these processes will potentially reveal new avenues for treatments.

PI_NAMEs: GOLDBERG, MARCIA B (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Area;Bacteria;Bacterial Infections;C-terminal;Caspase;cell growth;Cell membrane;Cell Proliferation;Cells;Communities;Cytosol;Data;Diarrhea;Disease;Docking;Event;Funding;Genetic Screening;Goals;Grant;Homologous Gene;Human;human pathogen;improved;Individual;Infection;innovation;insight;Integration Host Factors;interest;Invaded;Investigation;Mammalian Cell;Mediating;Medical;Membrane;Methods;Molecular Conformation;Movement;mutant;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phenotype;Play;Process;Proteins;recruit;response;Role;Shigella;Shigella flexneri;Shigella Infections;Site;Testing;translocase;Type III Secretion System Pathway;Yeasts

PROJECT_TITLE: Host factors in Shigella flexneri infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative NEXMIF is a novel X-linked ASD gene originally diagnosed only in males, but increasing reports have identified that female individuals of NEXMIF haploinsufficiency also demonstrate autistic symptoms. Using a female mouse model of NEXMIF haploinsufficiency, this grant proposes to determine the behavioral phenotypes and elucidate the alterations in neuron structural development and synaptic function resulting from the mosaic expression of NEXMIF in female mouse brains. Findings from the study will provide mechanistic insight into NEXMIF encephalopathy and set the basis for the development of therapeutical strategies for NEXMIF ASD.

PI_NAMEs: MAN, HENGYE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Age;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;Behavior Disorders;Behavioral;behavioral phenotyping;Biological Process;Brain;Brain region;Cells;Characteristics;Clinical;Communication;Complex;cost;Cues;Defect;Dendrites;Development;Diagnosis;Disease;Encephalopathies;Equilibrium;Etiology;Excitatory Postsynaptic Potentials;Family;Female;Functional impairment;Future;Gene Dosage;Genes;Genetic;Grant;Growth;Heterozygote;High Prevalence;Human;human female;Impairment;In Vitro;in vivo;Individual;Inherited;insight;Intellectual functioning disability;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;Language;Learning;Link;male;Mammalian Cell;Measures;Memory;Memory impairment;Microcephaly;migration;Molecular;Morphology;mosaic;mosaic pattern;mouse model;Mus;Names;Nature;nerve supply;neural network;neural patterning;Neurites;Neurobiology;neuron development;Neurons;neuropathology;novel;Patients;Pattern;Phenotype;Population;Process;protein expression;repetitive behavior;Reporting;Rodent Model;Seizures;sex;Signal Transduction;Slice;Social Interaction;Societies;Symptoms;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;Syndrome;Testing;therapeutic development;Transgenic Organisms;United States;Vertebral column;Visualization;Wild Type Mouse;women patients;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Neurodegenerative;Pediatric;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE It is widely known that the eukaryotic genome is segregated within three-dimensional nuclear space, with large, heterochromatic domains sequestered proximal to the nuclear lamina. Elucidating the molecular mechanisms responsible for the organization of the genome at the nuclear periphery will delineate how cell-type and differentiation-state specific chromatin configurations and higher-order genome organization are directed in health and disease. The results of my studies will identify the mechanistic drivers of lamina-associated domain establishment and maintenance, providing a fundamental principle governing peripheral heterochromatin organization that links gene expression, local genomic context and radial positioning.

PI_NAMEs: KARNAY, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: 3-Dimensional;Adopted;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;Chromosomes;Complex;Coupled;Coupling;Degenerative Disorder;Development;Developmental Process;Disease;Embryonic Development;Epigenetic Process;Etiology;experimental study;Fibrosis;Foundations;Fragile X Syndrome;Frequencies;Friedreich Ataxia;Functional disorder;Gene Expression;Gene Order;gene repression;Gene Silencing;Genes;Genetic;genetic element;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;genomic locus;Genomic Segment;Genomics;Health;Heart Hypertrophy;Heterochromatin;Histone H3;Human Development;human disease;Imaging technology;insight;Link;Lysine;Maintenance;Mammalian Cell;mammalian genome;Manuscripts;Mediating;Mediator;Mentors;Microscopy;Modification;Molecular;Neurodegenerative Disorders;Neurodevelopmental Disorder;Nuclear;Nuclear Lamina;Organogenesis;overexpression;Pathologic;Pathology;Peripheral;Plasmids;Play;Population;population based;Positioning Attribute;post-doctoral training;Process;programs;Proteins;Radial;Regulatory Element;Research;Research Personnel;Role;segregation;skills;Specificity;Testing;training opportunity;Work

PROJECT_TITLE: Deciphering the Molecular Orchestrators of Heterochromatin-Lamina Interactions at the Nuclear Periphery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: COLUMBIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cancer metabolic reprogramming plays an essential role in tumor development resulting in differential utilization of many essential metabolites by cancer cells compared to normal cells and has been recently recognized as a promising therapeutic target for the improved cancer treatments. However, cancer metabolic reprogramming is poorly understood due to the lack of tools that can quantify nutrient uptake in relevant animal models of human cancers. Here, we propose to develop a novel optical imaging platform that would become a universal analytical method for monitoring nutrient uptake in tumors and would help to understand metabolic vulnerabilities of many different cancers with the overall goal to generate novel, effective treatments.

PI_NAMEs: GOUN, ELENA  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Ablation;absorption;Address;Affinity;Amino Acids;analytical method;analytical tool;Animal Cancer Model;Animal Disease Models;Animal Model;Animals;Azides;Behavior;Biological;Biological Assay;biological systems;bioluminescence imaging;Breast Cancer Model;cancer cell;cancer therapy;Categories;Cell Culture Techniques;Cell model;Cells;Chemistry;chemotherapy;Clinical;clinical application;cost;CRISPR/Cas technology;Dependence;design;Development;Diabetes Mellitus;Disease Progression;drug discovery;effective therapy;Enzymes;Evaluation;experimental study;Fatty Acids;Fireflies;Generations;Glucose;glucose uptake;Glutamine;Goals;Human;human model;Human Pathology;Image;Imaging Device;imaging modality;imaging platform;Imaging Techniques;improved;In Vitro;in vitro Model;in vivo;inhibitor;interest;Intervention;Intraperitoneal Injections;intravenous injection;Investigation;Isotopes;Kinetics;Ligation;Light;Luc Gene;Luciferases;luciferin;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Methods;Modification;molecular imaging;Molecular Probes;Monitor;Mus;Nature;Neurodegenerative Disorders;new technology;non-invasive imaging;nonalcoholic steatohepatitis;Normal Cell;novel;nuclear imaging;Nucleosides;Nucleotides;Nutrient;Oleic Acids;Oncology;optical imaging;Optics;Oral;Pathologic;Physiological;Play;Positron-Emission Tomography;Process;Production;Proliferating;Publishing;Radioactive;Reaction;Reagent;Reporting;Role;Route;Safety;serial imaging;Signal Transduction;simulation;single photon emission computed tomography;small hairpin RNA;Specificity;Structure;success;Synthesis Chemistry;System;Techniques;Technology;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;Toxic effect;Transgenic Mice;Transgenic Organisms;Tryptophan;Tube;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumorigenesis;uptake;Validation;Work

PROJECT_TITLE: Optical platform for functional longitudinal imaging of metabolite uptake in vivo

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed work will elucidate the molecular basis of altered nucleoside diphosphate kinase (NDPK) activity in patients and animals with atrial fibrillation. The effects of enhanced NDPK signaling, altered cAMP levels near the ryanodine receptor channel complex, and abnormal intracellular calcium signaling will be studied in human and dog atrial cells and mouse models. These studies may lead to the development of new therapeutic approaches for atrial fibrillation.

PI_NAMEs: WEHRENS, XANDER H.T. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adaptor Signaling Protein;Animals;Ankyrin Repeat;Arrhythmia;Atrial Fibrillation;Binding;Biopsy;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium Signaling;canine model;Canis familiaris;Cell model;Chronic;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Event;Fluorescence Resonance Energy Transfer;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;gene therapy;Genetic;Goals;GTP-Binding Proteins;Guanosine Triphosphate;Heart;Heart Atrium;Human;improved;knock-down;Knock-in Mouse;Maintenance;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;new therapeutic target;novel;novel therapeutic intervention;Nucleoside diphosphate kinase B;Nucleoside-Diphosphate Kinase;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;preclinical study;Predisposition;prevent;Prevention;Production;Protein Isoforms;Proteomics;Publishing;receptor;regional difference;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Sarcoplasmic Reticulum;Second Messenger Systems;sensor;Signal Transduction;Tertiary Protein Structure;Testing;Therapeutic;Validation;Work

PROJECT_TITLE: Role of Nucleoside-Diphosphate Kinase Signaling in Atrial Fibrillation

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  The adrenal glands produce androgen precursors, which are known to be important during fetal and early development. Recent data suggest that a set of unique adrenal androgens, called 11-oxyandrogens, might play important roles in aging individuals. The proposed research aims to deeply characterize the patterns of 11- oxyandrogens in aging men and women, and to derive associations between 11-oxyandrogens and various age- related health outcomes, including bone, metabolic, cardiovascular, and general wellbeing.

PI_NAMEs: TURCU, ADINA F (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: 11-ketotestosterone;Address;Adrenal Glands;Adult;Age;age related;Aging;aging related;androgen excess;androgen independent prostate cancer;androgenic;Androgens;Androstenedione;Aromatase;Binding;Biological;Biological Availability;Biological Markers;bone;bone health;bone loss;cardiometabolic risk;cardiovascular health;Cardiovascular Pathology;Cardiovascular system;Clinical;Cognitive;cohort;comorbidity;Congenital adrenal hyperplasia;Cross-Sectional Studies;Data;Data Set;dehydroepiandrosterone;design;Development;Disease;Elderly;Eligibility Determination;epidemiology study;Estrogens;Fatty acid glycerol esters;fetal;Fetal Development;Fracture;Functional disorder;Goals;gonad function;Gonadal Steroid Hormones;Gonadal structure;Health;Heart;Hematocrit procedure;Hemoglobin;Human;Image Analysis;Individual;intraperitoneal;Knowledge;Laboratories;Longitudinal cohort;Longitudinal trends;Mass Spectrum Analysis;Measurement;Measures;men;Menopause;Metabolic;multi-ethnic;multi-racial;new therapeutic target;novel therapeutic intervention;Outcome;Participant;Pathology;Pattern;Perimenopause;Personal Satisfaction;Phenotype;Physiological;Physiology;Play;Postmenopause;premature adrenarche;Premenopause;Production;Puberty;Public Health;Recording of previous events;reproductive;Research;Role;Sampling;Serum;sex;Sexual Health;SHBG gene;Site;Source;Stanolone;Steroids;Sulfate;Surveys;Testing;Testosterone;Time;Time trend;trend;Visit;Woman;Women's study;Work

PROJECT_TITLE: 11-Oxyandrogens and Aging: Health Implications

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Our project aims to develop child-tailored quantitative imaging tools for assessing treatment effects in children with cancer while ensuring the lowest possible radiation exposure. We are testing novel diffusion-weighted magnetic resonance imaging and positron emission tomography technologies for therapy response assessment of pediatric cancers. We anticipate that child-tailored imaging tests will introduce a new, safer, more efficient, and more accurate generation of imaging exams for children that can be widely applied to interrogate health and disease without the risk of radiation-induced secondary cancers later in life.

PI_NAMEs: DALDRUP-LINK, HEIKE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Adult;Aftercare;Anatomy;anti-cancer research;Artificial Intelligence;artificial intelligence algorithm;Assessment tool;Attention;Biological Markers;Cancer Detection;cancer diagnosis;cancer imaging;cancer immunotherapy;cancer therapy;chemotherapy;Child;Childhood;Clinical;clinical application;clinical imaging;convolutional neural network;Data;Data Set;Development;diagnostic accuracy;Diagnostic Neoplasm Staging;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dose;Ensure;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Generations;Glucose;Goals;Health;Image;image reconstruction;imaging approach;Imaging Device;Imaging Techniques;Imaging technology;Immunotherapy;improved;Injections;ionization;Ionizing radiation;irradiation;leukemia;Life;Link;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of thyroid;Malignant Neoplasms;Measurement;Measures;Medical Imaging;Metabolic;Metabolism;minimally invasive;Mission;Monitor;MRI Scans;nanoparticle;National Cancer Institute;neoplasm immunotherapy;novel;novel imaging technology;Oncology;Organ;Outcome;Patient imaging;Patients;Pediatric Hospitals;Pediatric Neoplasm;Pediatric Oncology;pediatric patients;Pharmaceutical Preparations;Physiology;Population Study;Positioning Attribute;Positron-Emission Tomography;Predisposition;Protons;quantitative imaging;Radiation;Radiation Dose Unit;Radiation exposure;radiation risk;Radioactive;radiological imaging;Research;Research Personnel;response;Risk;Scanning;Second Primary Cancers;Sensitivity and Specificity;Staging;Standardization;Techniques;Technology;Testing;Therapeutic;Thoracic Radiography;Time;treatment effect;treatment response;tumor;tumor metabolism;tumor progression;uptake;whole body imaging;X-Ray Computed Tomography

PROJECT_TITLE: Advanced Imaging Tools to Assess Cancer Therapeutics in Pediatric

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE: Here we study how elevated serum triglycerides worsen pancreatitis severity by being cleaved to unsaturated ω6, ω9 fatty acids via pancreatic and lipoprotein lipase, and how the dietary replacement of these fats by ω3 or saturated fats, or inhibition of lipases may reduce the severity of hypertriglyceridemia associated pancreatitis.

PI_NAMEs: SINGH, VIJAY PREM (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Acceleration;acute pancreatitis;Adipocytes;Admission activity;Affect;Anticoagulants;aqueous;Behavior;Biological;Body System;cell injury;Citrates;Clinic;Clinical;clinically relevant;cost;Data;Diagnosis;dietary;Dietary Fats;Disease;enhancer-binding protein AP-2;Environment;Fatty acid glycerol esters;Fatty Acids;Gastroenterology;Generations;Genetic;hazard;Heparin;Heterogeneity;Hospitalization;Human;Hydrolysis;Hypertriglyceridemia;improved outcome;Inflammation;Injury;Intake;Lipase;Lipolysis;lipoprotein lipase;Literature;Membrane;Methods;Molecular;Morbidity - disease rate;mortality;Mus;Nonesterified Fatty Acids;novel;Organ failure;Outcome;Pancreas;Pancreatitis;Pathogenesis;Patient Admission;Patients;pi bond;Plasma Exchange;Prevalence;Recommendation;Reporting;response;Risk;Role;saturated fat;Saturated Fatty Acids;Serum;Severities;Signal Transduction;sound;Time;Toxic effect;Transcription Factor AP-1;treatment response;Triglycerides;Unsaturated Fatty Acids;uptake;Visceral;Visceral fat;Work

PROJECT_TITLE: Fat in Pancreatitis - a Focus on Hypertriglyceridemic Pancreatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Emerging Infectious Diseases;Hematology;Infectious Diseases;Influenza;Pancreatic Cancer;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This project will investigate the role of tissue factor (TF) and TF-dependent signaling in venous thrombosis and growth of human pancreatic cancer, as well as its contribution to antiviral innate immune responses. We will use a novel mouse model of human pancreatic cancer. In addition, we will improve the current assays to measure extracellular vesicle TF and will identify risk markers for thrombosis in plasma. Furthermore, we will use two well described infection models with Coxsackievirus B3 myocarditis and H1N1 influenza A pneumonia. Our long-term goals are to further understand the protective and pathologic roles of TF, coagulation proteases and PARs in cancer and infections. Our studies might lead to new therapies to improve human health.

PI_NAMEs: MACKMAN, NIGEL  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Affinity;Atherosclerosis;Bacterial Infections;Biological Assay;Biological Markers;biomarker identification;Cancer Patient;Choristoma;Clinical;Coagulation Process;Complex;Coxsackie Viruses;Disseminated Intravascular Coagulation;Endotoxemia;enhancing factor;extracellular vesicles;F2R gene;Funding;Funding Mechanisms;Generations;Goals;Grant;Growth;Health;Heart;Hemostatic function;high reward;high risk;Human;human model;Immune response;improved;Infection;influenza A pneumonia;Influenza A virus;Influenza A Virus, H1N1 Subtype;Innate Immune Response;Integral Membrane Protein;Knowledge;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Modeling;mouse model;Mus;Myocarditis;National Heart, Lung, and Blood Institute;new technology;novel;novel therapeutics;pancreatic cancer patients;pancreatic neoplasm;pathogen;Pathologic;Pathway interactions;Peptide Hydrolases;Plasma;Play;prevent;protein function;Proteinase-Activated Receptors;Proteomics;receptor;Reperfusion Injury;response;Risk;Risk Marker;Role;Sampling;Signal Transduction;Source;System;Thrombin;Thromboplastin;Thrombosis;thrombotic;Time;tumor;tumor growth;Tumor-Derived;venous thromboembolism;Venous Thrombosis;Viral;Virus Diseases

PROJECT_TITLE: Tissue factor-dependent coagulation in thrombosis and immune responses


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Mental Health;Prevention;Vaccine Related

ORG_CITY: KENSINGTON

ORG_NAME: TENDEL THERAPIES INC.

PHR: We are seeking effective regimen for therapeutic or prophylactic vaccination against the human immunodeficiency virus (HIV). The strategy is to use targeted immunostimulants to guide the immune system to production of antibodies that neutralize the virus, which are thought to be an essential component of an effective vaccine. We will test newly developed immunostimulants for their capacity to elicit such neutralizing antibodies and determine the breadth of suppression achieved against diverse HIV strains.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J.;SPARGER, ELLEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: 2019-nCoV;Adjuvant;Affinity;Amino Acids;Anti-Retroviral Agents;Antibodies;Antibody Formation;Antibody Response;Antigens;Attenuated Vaccines;B-Cell Development;B-Lymphocytes;Bacteriophages;Binding;Binding Sites;Cells;Clinical Trials;COVID-19 vaccine;Data;design;Development;Disease Progression;Disease remission;Epitopes;Evaluation;experimental study;Frequencies;Frustration;Funding;Genetic;Germ Lines;Goals;Government;Hand;Helper-Inducer T-Lymphocyte;HIV;HIV envelope protein;HIV vaccine;HIV-1;Human;Immune system;Immunization;immunogenicity;Immunologic Adjuvants;improved;Infection;Left;lipid nanoparticle;Macaca;Messenger RNA;N-terminal;neutralizing antibody;nonhuman primate;novel;Peptides;Persons;Pharmacotherapy;Polymers;Preventative vaccination;Primates;receptor binding;recruit;Regimen;research clinical testing;response;Series;Structure of germinal center of lymph node;Surface;Technology;Testing;therapeutically effective;V3 Loop;Vaccination;vaccination protocol;vaccine development;Vaccine Therapy;Vaccines;vector;vector vaccine;Virus;Work

PROJECT_TITLE: Genetic adjuvants to elicit neutralizing antibodies against HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Millions of Americans are exposed to repetitive head impacts (RHI) through contact and collision sports (CCS) annually and may be at increased risk for later-life cognitive decline, mood and behavioral disturbances, and dementia. Yet, specific risk factors for these outcomes are unknown due to limitations of previous research, including: small samples, focus on male professional American football players, recruitment biases, and reliance on retrospective reports from informants of deceased athletes. The proposed study will address these limitations and be among the first to examine risk factors for, and characterize the frequency, severity, and profile of cognitive impairment, mood and behavioral disturbances, and dementia, in female and male former soccer players and male former American football players, by leveraging the existing Brain Health Registry to create the Head Impact and Trauma Surveillance Study (HITSS), which will be the largest longitudinal registry of female and male CCS athletes to date.

PI_NAMEs: ALOSCO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Address;Advertising;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Behavioral;Black race;Blood Vessels;Brain Concussion;Brain Health Registry;California;Caregivers;chronic traumatic encephalopathy;Cognitive;cognitive reserve;cognitive testing;college;comparison group;contact sports;Country;Craniocerebral Trauma;Data;Data Set;Dementia;dementia risk;demographics;design;Development;Emotional;enhancing factor;Enrollment;Epidemiologic Methods;Episodic memory;executive function;Exhibits;Exposure to;Female;follow-up;Frequencies;Functional disorder;functional status;Future;Goals;head impact;Health;Health behavior;high school;Impaired cognition;Impairment;Impulsivity;informant;interest;Knowledge;late life;Longitudinal Studies;male;Manufactured football;Measures;Medical;Mental Depression;Moods;neurobehavioral;neurodegenerative dementia;Neurodegenerative Disorders;Neurologic;neuropsychiatric symptom;neuropsychiatry;online registry;Outcome;outreach;Participant;Patient Self-Report;performance tests;Persons;Play;poor sleep;Positioning Attribute;Prevalence;Questionnaires;Race;Readiness;Recording of previous events;recruit;Registries;Reporting;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Sampling;San Francisco;Scientific Advances and Accomplishments;Scoring Method;Severities;sex;sleep quality;Soccer;social media;Standardization;subconcussion;Substance abuse problem;Substance Use Disorder;surveillance study;Testing;Traumatic Brain Injury;Universities;vascular risk factor;web site;Woman

PROJECT_TITLE: Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Cortical inhibitory interneurons (INs) balance and shape excitatory pyramidal neuron (PN) activity in normal cortical circuits and have been implicated in the etiology of brain disorders such as autism, schizophrenia, and epilepsy. However, little is known about the molecular mechanisms shaping synaptic connectivity of local IN circuits. Our studies will provide novel insights into the molecular identities and their interactions that govern synaptic specificity of IN networks and eventually open the floodgate to restoring brain function in disordered/damaged brains.

PI_NAMEs: TANIGUCHI, HIROKI  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Adhesions;autism spectrum disorder;Automobile Driving;Axon;Binding;Biological Assay;Brain;Brain Diseases;Brain Injuries;cell type;Cells;Data;Development;Disease;Ectopic Expression;Electroporation;Ensure;Epilepsy;Equilibrium;Etiology;experimental study;Functional disorder;Gene Expression;Gene Transfer;Generations;genome editing;Germ Lines;Goals;hippocampal pyramidal neuron;in vivo;Individual;Induced Neurons;insight;Interneurons;Knock-out;Knockout Mice;Location;malformation;Medial;Mediating;Modeling;Molecular;Morphology;mouse genetics;Mus;neurofascin;Neurons;novel;permissiveness;Phenotype;Physiology;Play;postsynaptic neurons;Prefrontal Cortex;presynaptic;presynaptic neurons;Presynaptic Terminals;Property;Proteins;receptor;repaired;Role;Schizophrenia;Series;Shapes;Signal Transduction;Specificity;stereotypy;success;Synapses;synaptogenesis;System;Testing;Therapeutic;Transplantation;Viral Genes

PROJECT_TITLE: Molecular mechanisms underlying cortical interneuron synaptic specificity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Breast Cancer;Cancer;Precision Medicine;Women's Health Research

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Resistance to therapies is a cross-cutting and significant challenge. The challenge exists even for cancers targeted by precision therapies, as is the case with HER2-positive breast cancer. New tools capable of measuring understanding the mechanisms that cancer uses to subvert therapy are critical to informing design of next generation therapeutics.

PI_NAMEs: HERR, AMY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acceleration;Address;Articulation;Assessment tool;Automobile Driving;Binding;Biological;Biological Assay;biological heterogeneity;Biological Markers;Biology;Biomedical Engineering;Biometry;Biopsy;Breast biopsy;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer drug resistance;Cells;Chemistry;chemotherapy;Classification;Clinical;clinically relevant;Computational Biology;design;Detection;Development;Diagnosis;dimer;Dimerization;DNA;DNA Sequence Alteration;Drug resistance;drug resistance development;Drug Targeting;ERBB2 gene;ERBB3 gene;Exhibits;experience;Extracellular Domain;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;fundamental research;Genomics;Goals;Heterogeneity;Homo;improved;In Situ Hybridization;Individual;individualized medicine;Knowledge;Length;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Measurement;Measures;Medicine;Membrane;Microfluidics;Molecular;Monitor;multimodality;mutant;Mutation;Nature;neoplastic cell;news;next generation;novel therapeutics;Nuclear;Oncogenic;oncology program;overexpression;patient oriented;Patients;Pertuzumab;Pharmaceutical Preparations;PIK3CA gene;Play;Population Analysis;precision medicine;Precision therapeutics;Productivity;Prognostic Marker;protein complex;Protein Family;Protein Isoforms;Proteins;Proteomics;Radiation therapy;Recurrence;Research;Resistance;Resolution;Retinal blind spot;Role;Signal Transduction;single cell analysis;Specificity;stem;success;Surface;Survival Rate;targeted cancer therapy;targeted treatment;therapy resistant;Tissue Banks;Tissue Sample;Tissues;tool;Trastuzumab;tumor heterogeneity;Variant;Western Blotting

PROJECT_TITLE: MULTIPLEXED ISOFORM QUANTIFICATION IN HER2-POSITIVE BREAST CANCER

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Legionnaires’ Disease is a type of bacterial pneumonia caused by the pathogen Legionella pneumophila, which infects the elderly and individuals who suffer from chronic lung disease or are immunocompromised. During infection of host cells, Legionella secretes a number of effector proteins that alter cellular signaling, including lysine methyltransferases that methylate chromatin to repress the expression of genes involved in immune response. Structural and biochemical studies of these enzymes will yield new insight into their biological functions in Legionella pathogenesis and inform the development of therapeutics to treat Legionnaires’ Disease.

PI_NAMEs: TRIEVEL, RAYMOND C (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affect;Agreement;American;Amino Acids;Amoeba genus;Ankyrin Repeat;Architecture;atypical pneumonia;Bacterial Pneumonia;Binding;Biochemical;Biochemistry;Biocide;Biological;Biological Assay;Biological Process;C-terminal;Categories;Cell Death;Cell Nucleus;Cells;Chromatin;chromatin modification;Chronic lung disease;combat;Complement;Complex;Coupled;Cryoelectron Microscopy;Data;Defect;Disease;Distal;DNA;Elderly;Elements;Enzymes;Etiology;Exhibits;Fatality rate;Foundations;Gene Deletion;Gene Expression;Gene Expression Regulation;gene repression;Genes;genome-wide;Histone H3;histone methylation;Histone-Lysine N-Methyltransferase;Histones;Immune;Immune response;Immunocompromised Host;Impairment;In Vitro;Individual;Infection;inhibitor;Innate Immune Response;insight;interdisciplinary collaboration;Kinetics;Laboratories;Legionella;Legionella pneumophila;Legionnaires' Disease;Lung;Lysine;Macrophage;Maps;Mediating;Membrane;Methylation;Methyltransferase;Michigan;Microbiology;microscopic imaging;Modification;Molecular;molecular pathology;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;N-terminal;nanomolar;Natural Immunity;novel;novel therapeutics;Nuclear;Nucleosomes;Orthologous Gene;Paris, France;particle;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Peptides;programs;Protein Secretion;Proteins;Reader;Repression;Roentgen Rays;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;SET Domain;Signal Pathway;Signal Transduction;Site;Specificity;structural biology;Structure;Substrate Specificity;Tail;Testing;therapeutic development;trafficking;Universities;Virulence

PROJECT_TITLE: Structure and Function of Legionella pneumophila Lysine Methyltransferases

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;Mental Health;Pediatric;Prevention;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative  Substance use and dependence (SUD) develop and progress within problematic family interactions and relationships, yet traditional methods of analyzing interactions do not capture key dynamic parameters. This research will apply state-of-the art statistical methods to study the longitudinal effects of early family dynamics on adolescent SUD, and test mediation of genetic risk and family intervention effects based on randomization to the Family Check-Up and control conditions. The advanced investigation of the intervention mechanisms will inform the specification and refinement of more potent and effective family-based interventions.

PI_NAMEs: LEMERY-CHALFANT, KATHRYN ;TEIN, JENN-YUN  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adolescent Development;adolescent substance use;Affect;Age;antisocial behavior;base;Behavioral;biobank;biological sex;biological systems;checkup examination;Child;Child Development;Code;Coercion;Computer software;Data;Data Analyses;Data Analytics;Development;Distal;dosage;early childhood;effective intervention;Effectiveness of Interventions;Environment;Equation;ethnic diversity;Ethnic Origin;evidence base;Family;Family dynamics;Family Relationship;Family Research;Future;Genes;Genetic;genetic association;Genetic Risk;genome wide association study;Genotype;Goals;Heritability;Home;improved;Intervention;intervention effect;Investigation;Link;Longitudinal Studies;Longterm Follow-up;Measures;Mediating;Mediation;Mental Health;Methodology;Methods;Modeling;Modernization;multi-site trial;next generation;Outcome;Parent-Child Relations;Parents;Pathogenicity;Pattern;Predisposition;prevent;Prevention;Problem behavior;Process;prognostic;Psychopathology;Race;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research;resilience;Risk;Role;Sampling;secondary analysis;social;Social Desirability;social influence;Social Interaction;Social Processes;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Stress;Substance Addiction;substance use;Substance Use Disorder;Survival Analysis;Testing;theories;Time;Videotape;Youth

PROJECT_TITLE: Parent-Child Interaction Dynamics Mediate Genetic and Prevention Effects on the Development of Adolescent Substance Use Disorders


PHR: Narrative The goal of this research is to understand better the molecular genetic mechanisms that contribute to blood platelet reactivity and stroke outcomes, and to develop better targets for drug development to treat ischemic vascular disease based on an individual’s physiology.

PI_NAMEs: CAMPBELL, ROBERT A (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adherence;Adhesions;Agonist;Alleles;artery occlusion;Binding;Biology;Black Populations;Blood Platelets;Brain hemorrhage;Brain Ischemia;Cathepsin G;Cell Line;Clinical;Clinical Data;Co-Immunoprecipitations;Cyclic AMP;Cytoplasmic Granules;Data;desensitization;Disease;drug development;Drug or chemical Tissue Distribution;Drug Targeting;Epoprostenol;F2R gene;Funding;G-Protein-Coupled Receptors;Gases;Gene Frequency;Generations;Genetic;genetic manipulation;Genotype;Goals;Heart;Hemorrhage;Heterodimerization;Human;Hyperactivity;In Vitro;in vivo;in vivo Model;Incidence;Individual;Infarction;inter-individual variation;Ischemia;Ischemic Stroke;Kinetics;Leukocytes;Ligands;Liver;Lung;Mediating;Megakaryocytes;Molecular;Molecular Genetics;mouse model;mouse protease-activated receptor 4;Mus;neutrophil;Neutrophil Infiltration;novel;Outcome;Patients;Peptide Hydrolases;Peptides;Pharmacogenetics;Phosphatidylserines;Physiology;Platelet Activation;Platelet aggregation;platelet function;Property;Prostaglandins I;protease-activated receptor 3;protease-activated receptor 4;Proteins;Race;receptor;recruit;Reperfusion Injury;Research;Resistance;response;Risk;RNA;Role;Serine Protease;shear stress;Signal Pathway;Signal Transduction;Site;Stroke;stroke model;stroke outcome;stroke risk;Thrombin;Thrombin Receptor;Thrombus;Time;Tissues;transcriptome;user-friendly;Variant;Vascular Diseases;web-based tool;Work

PROJECT_TITLE: Human platelet PAR4: novel activation, interindividual variation, and neutrophil interactions in vivo and in vitro

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The proposed research aims to study the intrinsic and synaptic adaptations of pyramidal neurons in the layer V of the primary motor cortex using experimental models of Parkinson’s disease (PD). With this research, we will gain mechanistic understanding of the aberrant motor cortical activity seen in individuals afflicted by PD, providing critical insight into PD’s pathophysiology that can help us to improve the treatment of this devastating disease. Therefore, this research is relevant to the missions of the NIH and the NINDS.

PI_NAMEs: CHU, HONG-YUAN  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Age;aging related disease;Basal Ganglia;Biological Markers;biophysical techniques;Bradykinesia;Brain;Cells;cellular pathology;Clinical Research;Closure by clamp;Corpus striatum structure;Coupled;Data;defined contribution;design;Development;Disease;Disease Progression;dopaminergic neuron;Economic Burden;Electrophysiology (science);Exhibits;Experimental Models;Experimental Parkinsonism;experimental study;Functional disorder;Functional impairment;Gene Expression;Genetic;Heterogeneity;hippocampal pyramidal neuron;Impairment;improved;Individual;Induced Neurons;insight;Knowledge;Lesion;Levodopa;Link;Mission;mitopark mouse;Modeling;Molecular;Motor;motor control;Motor Cortex;motor deficit;motor disorder;Motor Skills;motor symptom;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel;optogenetics;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;patch clamp;pharmacologic;Physiological;Play;Population;Property;Pyramidal Tracts;Research;response;Role;Secondary to;socioeconomics;Structure;Substantia nigra structure;Synapses;Techniques;Time;tool;United States National Institutes of Health

PROJECT_TITLE: Motor cortical circuitry adaptations in experimental Parkinson's disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: RELEVANCE As the World Health Organization works with local officials to eliminate malaria in the Greater Mekong Subregion, local information about parasite migration will be important for stratifying malaria risk. In the proposed research, we will identify recent and local malaria parasite migration patterns within a well-characterized border region of northern Cambodia and Thailand and determine how these patterns are affected by local human travel. If successful, this research will illuminate the contribution of movement by local population groups to spatial patterns of malaria parasite migration and will provide a framework to identify specific geographic areas for targeted intervention, which can be adapted to other malaria-endemic areas.

PI_NAMEs: HARRISON, SHANNON TAKALA (contact);O'CONNOR, TIMOTHY DAVID

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Admixture;Affect;Area;Artemisinins;Automobile Driving;Buffers;Cambodia;Cessation of life;Combined Modality Therapy;Country;Data;Drug resistance;Environmental Risk Factor;Exhibits;falls;genome-wide;Genomic approach;genomic data;Genomics;Geographic Locations;Geography;Haplotypes;Human;identity by descent;Infection;Intervention;Malaria;Maps;Methods;migration;Modeling;Movement;Multi-Drug Resistance;Occupations;Outcome;Parasites;Pattern;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium vivax;Population;Population Group;preservation;prevent;programs;Property;Recording of previous events;Relapse;Research;resistant Plasmodium falciparum;Resource Allocation;Resources;response;Risk;Sampling;Side;Site;Source;Structure;Surface;Thailand;transmission process;Travel;Validation;Variant;vector mosquito;whole genome;Work;World Health Organization

PROJECT_TITLE: Genomic and geospatial analyses of malaria parasite migration to inform elimination

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Despite the major advances in cardiac interventions, diabetic ischemic heart failure morbidity and mortality continue to rise. It is increasingly recognized that integrative approaches, rather those purely focusing on cardiomyocytes, must be undertaken for diabetic ischemic heart failure prevention/treatment. The current application endeavors to explore the basis of diabetic cardiac impairment mechanisms, adiponectin-resistance mediated microvascular circulatory dysfunction, with the ultimate goal of identifying new therapeutic targets at the molecular, cellular, and organ level in in vivo animal models, for the purpose of ameliorating diabetic ischemic heart failure.

PI_NAMEs: WANG, YAJING  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adipocytes;adipokines;adiponectin;Affect;angiogenesis;Animal Model;Animals;Antioxidants;Attenuated;Blood;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Clinical Research;Coronary;Coronary Circulation;Data;desensitization;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Down-Regulation;effective therapy;Endocrine system;Endothelial Cells;Exhibits;experimental study;Extravasation;Family member;Functional disorder;G protein coupled receptor kinase;gain of function;Genetic;glycemic control;Goals;GRK5 gene;Health;Heart;Heart failure;Heart Injuries;Homeostasis;Human;Hyperglycemia;Impairment;improved;in vitro Model;in vivo;Incidence;Injury;Intervention;ischemic cardiomyopathy;Knock-in;Knock-out;Knockout Mice;Knowledge;Leptin;loss of function;Mediating;Membrane;Microcirculation;Molecular;Morbidity - disease rate;mortality;mRNA Expression;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;new therapeutic target;non-diabetic;novel;Organ;Oxidative Stress;Pathologic;Patient Care;Patients;Phenotype;Phosphorylation;Phosphorylation Site;Play;Post-Translational Protein Processing;preservation;Prevention;Production;Prognosis;protein expression;Proteins;Proteomics;prototype;Publishing;receptor;Regulation;Reporting;Research;Resistance;response;Role;Signal Transduction;Site;success;Supplementation;System;Testing;therapeutically effective;therapy development;Time;treatment strategy;Type 2 diabetic;Ubiquitination;Up-Regulation;Vascular blood supply;Vascular Diseases;Work

PROJECT_TITLE: Dysregulated Adiponectin Transmembrane Signaling in Diabetic CoronaryVascular Injury and Heart Failure

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Microbiome;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Multidrug resistant organisms (MDROs) are bacteria that have become resistant to more than one antibiotic and disproportionality affect the elderly residing in nursing homes, while high-throughput sequencing and large-scale data collection are integral to understanding the microbiome and its relation to age related disease. Our goal is to assess the gut microbiome of nursing home residents to determine carriage risk of MDROs and to assess the microbiomes influence on local and systemic immune functioning. We will develop novel rapid sequencing technology to better track these pathogens and define a microbiome and clinical based model to understand how age-related microbiome alterations as well as systemic immune functioning predicts the risk of both MDRO colonization and infection, in order to provide the basis for informing rational interventions and public health policies to better combat nursing home associated infections.

PI_NAMEs: BUCCI, VANNI ;HARAN, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;age-related disease;Aging;Algorithms;anti-microbial drug;Antibiotics;Bacteria;Bacterial Infections;Blood specimen;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic;Clinical;Clostridium difficile;cohort;Colon;Colonic inflammation;combat;Communicable Diseases;Communities;cost;cost effective;Data;Data Collection;Deterioration;Development;Diagnostic Procedure;Disease;dysbiosis;Elderly;Enrollment;epidemiology study;Epithelium;Exhibits;follow-up;Frail Elderly;frailty;Functional disorder;Future;Genomics;Genotype;Goals;gut colonization;gut dysbiosis;gut inflammation;gut microbiome;Health;Health Policy;healthy aging;High Prevalence;High-Throughput Nucleotide Sequencing;Home environment;Homeostasis;host microbiome;immune function;Immune system;Immune System Diseases;immunosenescence;improved;In Vitro;in vivo;indexing;Individual;Infection;Infectious Agent;Inflammaging;Inflammation;Inflammatory;Intervention;intestinal epithelium;Intestines;Knowledge;Label;large scale data;Methods;microbial;microbiome;microbiome alteration;microbiome analysis;microbiome composition;microbiome signature;microbiome therapeutics;Modeling;Molecular;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;novel;novel strategies;Nursing Homes;older adult;Organism;Organism Strains;pathogen;pathogenic microbe;Pathogenicity;Performance;Peripheral;Pharmaceutical Preparations;Population;predictive tools;Predisposition;Prevalence;prevent;Prevention;prospective;Public Health;residence;Residencies;Resistance;Resolution;Risk;Risk Factors;risk prediction;Sampling;Shapes;Site;stool sample;System;systemic inflammatory response;T-Lymphocyte;Technology;Testing;Time;transmission process;Vulnerable Populations

PROJECT_TITLE: Aging Microbiome, Immunosenescence, and risk of Multi-drug Resistant Organism Colonization and Infection in the Nursing Home

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Persons living with HIV face a higher than expected risk of cardiovascular disease for unknown reasons. This proposal will help to identify mechanisms that are associated with this increased risk which can identify novel interventions to reduce CV risk as well as have a beneficial impact on HIV disease and other comorbidities.

PI_NAMEs: HSUE, PRISCILLA Y. (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: aged;Anti-Inflammatory Agents;aptamer;Atherosclerosis;Award;Basic Science;Biological;Blood Cells;Blood Vessels;Bone Marrow;burden of illness;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Chronic;Clinic;Clinical;clinical center;Clinical Data;clinical predictors;Clinical Research;Clinical Trials;comorbidity;Coronary heart disease;Data;Development;disability-adjusted life years;Disease;Event;Extramedullary Hematopoiesis;Face;fluorodeoxyglucose positron emission tomography;follow-up;Foundations;Funding;General Population;Goals;Grant;Heart failure;Hematopoiesis;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;HIV;HIV Infections;Image;immune activation;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Infrastructure;inhibitor;Interleukin-1 beta;Intervention;Investigation;Kidney Diseases;Laboratories;Leadership;Link;Lipids;lymph nodes;Malignant Neoplasms;Mentors;Meta-Analysis;Metabolic;Monoclonal Antibodies;mortality;multidisciplinary;Mutation;novel;Older Population;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Persons;PET/CT scan;Play;Prevalence;prevent;Process;progenitor;protein biomarkers;Proteins;proteomic signature;Proteomics;Publications;Pulmonary Hypertension;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;San Francisco;Science;Site;Somatic Mutation;stem cells;sudden cardiac death;Technology;Time;Training;Translational Research;translational research program;translational study;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Role of Hematopoietic System and Proteomics in HIV-Associated Cardiovascular Disease

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative This proposal will consider (a) latency (lag) effects of both harmful and beneficial effects of exposures in ophthalmic studies (b) ordinal regression models to assess change in ordinal scales in longitudinal ophthalmic scales, such as the AREDS severity scale as an alternative to survival analysis to precisely capture changes in disease severity before a final endpoint (e.g., advanced AMD in studies of macular degenration, or total blindness in studies of diabetic retinopathy) is reached (c) assessment of measures of discrimination and risk reclassification when comparing risk models in ophthalmology using the eye as the unit of analysis, and (d) translational work on clustered data methods for the eye research community with a focus on (a) survival analysis, (b) binary longitudinal outcome data and (c) sample size/power estimation.

PI_NAMEs: ROSNER, BERNARD A (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Adverse effects;Affect;Age related macular degeneration;analytical method;Area;Bilateral;Blindness;Cataract;Categories;Chronic;Cicatrix;Classification;Clinical;cohort;Communities;Cox Models;Cox Proportional Hazards Models;Data;Data Correlations;Data Set;Development;Diabetic Retinopathy;dietary;Dietary intake;Discrimination;Dose;Elderly;Environmental Risk Factor;Epidemiology;Event;Eye;Eye diseases;Eyedrops;Genetic;Goals;Grant;improved;Individual;Inflammation;Literature;longitudinal analysis;Longitudinal cohort study;Lutein;macula;Manuscripts;Measures;Methods;Modeling;Morbidity - disease rate;older adult;Omega-3 Fatty Acids;Ophthalmology;Outcome;Paper;Patients;Pharmacoepidemiology;Predictive Value;Probability;programs;protective factors;Publishing;Randomized;reduce symptoms;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;risk prediction;ROC Curve;Sample Size;Sampling;Severities;Severity of illness;simulation;Statistical Methods;Survival Analysis;symposium;Time;Topical Corticosteroids;Training Programs;Translations;Uveitis;Vision;Visit;Visual impairment;Work;Writing;zeaxanthin

PROJECT_TITLE: Use of Correlated Data Methods in Ophthalmology


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Stroke Preclinical Assessment Network is a multicenter preclinical randomized controlled trial modeled after human clinical trials. This Network will test up to 8 of the most promising drugs for stroke. We expect to advance the most effective of these 8 promising drugs into human clinical trial to find the best treatments for stroke.

PI_NAMEs: DHANDAPANI, KRISHNAN M.;HESS, DAVID C. (contact);KHAN, MOHAMMAD BADRUZZAMAN

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;acute stroke;Adherence;Aging;Alteplase;animal imaging;Animal Model;Animals;Autologous;behavior test;Blood flow;cerebroprotection;Circadian Rhythms;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;comorbidity;Data;Dedications;Development;disabled;endovascular thrombectomy;Environment;experience;Failure;Family suidae;FDA approved;Filament;follow-up;functional outcomes;Future;Human;Hyperglycemia;improved;Inbred SHR Rats;Infarction;Intervention;Ischemic Stroke;Laboratories;Ligation;Magnetic Resonance Imaging;Manuscripts;medical schools;Mentors;Methodology;Middle Cerebral Artery Infarction;Middle Cerebral Artery Occlusion;Modeling;Mus;National Institute of Neurological Disorders and Stroke;Network Infrastructure;network models;neuroimaging;neuroprotection;Neuroprotective Agents;next generation;novel therapeutics;Obese Mice;Outcome;outcome prediction;Patients;Performance;Pharmaceutical Preparations;Phase II Clinical Trials;physiologic model;Postdoctoral Fellow;pre-clinical;pre-clinical assessment;Protocols documentation;randomized, clinical trials;Randomized, Controlled Trials;Rattus;Reporting;Research Personnel;Rodent;Scanning;single photon emission computed tomography;Site;Stroke;stroke model;stroke therapy;System;Testing;Therapeutic;thrombolysis;Training;Training and Infrastructure;training opportunity;Translations;Universities

PROJECT_TITLE: Augusta SPAN 2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PHR: NARRATIVE: This project address the major challenge of improving the quality of vaccine-elicited responses against the neutralizing antibody targets on the virus pathogen by novel immunogen design. This study proposes to modify vaccine candidates derived from Zika virus (ZIKV) envelope glycoprotein for efficiently activating and expanding ZIKV neutralizing antibody precursor to achieve potent antibody response elicitation, and to avoid stimulating non-neutralizing precursors that cross-react with envelope glycoproteins from Dengue virus (DENV) with potential risk of mediating antibody dependent enhancement for DENV infection. The outcomes of this study will contribute to the development of a safe and effective Zika virus vaccine as well as increase understanding of host/pathogen interactions.

PI_NAMEs: LI, YUXING  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Adjuvant;Adult;Affect;Animal Model;Animals;Antibodies;Antibody Formation;Antibody Response;Antibody-Dependent Enhancement;Antigens;Area;B cell repertoire;B-Lymphocytes;Binding;Bite;Cell Separation;Cells;Clinical Research;Cross Reactions;cross reactivity;Cryoelectron Microscopy;Culicidae;Dengue;Dengue Infection;Dengue Virus;design;Development;dimer;disorder prevention;E protein;emerging pathogen;env Gene Products;Epidemic;Epitopes;Event;Family;Feedback;fetal;Fetal Death;Fetus;Flavivirus;Flavivirus Infections;Future;global health;Glycoproteins;Guillain Barré Syndrome;Human;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin Genes;Immunologic Stimulation;improved;In Vitro;in vitro Assay;in vivo;Infection;Infectious Agent;innovation;insight;Investigation;Lead;Mediating;member;Membrane;Morbidity - disease rate;mouse model;Mus;Mutation;neutralizing antibody;next generation;nonhuman primate;novel;novel vaccines;Outcome;Outcome Study;pathogen;pathogenic virus;Pregnancy;Pregnant Women;prevent;Process;programs;Protein Engineering;prototype;Resolution;response;Risk;Sequence Homology;Series;Sexual Transmission;Structure;Symptoms;Transgenic Organisms;transmission process;vaccine candidate;Vaccine Design;Vaccines;Vertical Transmission;Viral;Virus;virus envelope;X-Ray Crystallography;ZIKA;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: Anti-flavivirus B cell response analysis to aid vaccine design

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative: This study examines the possibility of using administrative data (e.g., Medicare; electronic health records) to ascertain outcomes in pragmatic clinical trials through automated algorithm development. If successful, the study will position us to make a large contribution to the field of aging research by establishing a framework for more efficiently designing and running pragmatic clinical trials, especially from a cost perspective.

PI_NAMEs: ESSERMAN, DENISE  (contact);GANZ, DAVID ;LATHAM, NANCY K

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;adjudication;Adult;Aging;Agreement;algorithm development;Algorithms;automated algorithm;Caring;clinical care;Clinical Data;Clinical Trials;Cluster randomized trial;Code;Communities;comparative;cost;Cost Analysis;cost comparison;Cost efficiency;Cost Savings;Coupled;Data;Data Collection;Data Sources;design;Detection;Diagnosis;Elderly;Electronic Health Record;Eligibility Determination;Event;fall injury;Fee-for-Service Plans;follow-up;Gills;Goals;health care service utilization;health care settings;health data;Healthcare Systems;human old age (65+);Individual;Injury;insight;International Classification of Diseases;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;intervention effect;Machine Learning;machine learning algorithm;Medical Records;Medicare;Methods;Modeling;multiple data sources;Myocardial Infarction;older adult;Outcome;Participant;participant interview;Patient Self-Report;Patients;Population;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;primary outcome;prospective;Publishing;Reference Standards;Reproducibility;Research;Research Personnel;Research Proposals;Running;Savings;Sensitivity and Specificity;simulation;Site;Source;Stroke;System;Techniques;Testing;Text;Time;treatment as usual;Variant;Work

PROJECT_TITLE: Enhancing the Efficiency of Pragmatic Clinical Trials Using Administrative Data: Analysis of the STRIDE Study

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Estrogen;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE For symptomatic long QT patients prone to life threatening cardiac arrhythmia, pregnancy can facilitate a unique period of anti-arrhythmic protection of maternal life, when estrogen hormone level is at its highest. The current proposal seeks to employ LQT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as a platform to investigate the effect of estrogen on arrhythmic propensity and the molecular pathways that facilitate its activity. The identified beneficial anti-arrhythmic molecular targets will be employed to optimize the design of an estrogen analogue with the intention of proposing new therapeutic entities that take advantage of hormone-based anti-arrhythmic benefits, for the treatment of both male and female patients at all ages, thus promoting the field of sex-specific therapeutics and translational and precision medicine.

PI_NAMEs: ITZHAKI, ILANIT  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute;Advisory Committees;Age;analog;Anti-Arrhythmia Agents;Arrhythmia;Biological Assay;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cardiology;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career;career development;Career Mobility;Cells;Clinical Research;Complement;CRISPR/Cas technology;Dangerousness;Databases;design;Development;Disease;drug discovery;Electrophysiology (science);Engineering;Estradiol;Estrogen Analogues;Estrogen Receptors;estrogenic;estrogenic activity;Estrogens;Female;female sex hormone;Foundations;Future;genome editing;Goals;Gonadal Steroid Hormones;Homeostasis;Hormones;Human;Hyperactivity;Image;imaging approach;in silico;Individual;induced pluripotent stem cell derived cardiomyocytes;insight;Intention;Knowledge;knowledge base;Life;Long QT Syndrome;male;Maps;Mediating;Medicine;meetings;men;Mentors;Mentorship;Modeling;Modification;Molecular;Molecular Target;monolayer;multi-electrode arrays;Myocardial tissue;new therapeutic target;novel therapeutics;Optics;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmacogenomics;Phase;Phenotype;precision medicine;Predisposition;Pregnancy;preservation;Process;Program Development;programs;reproductive;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;RyR2;screening;Screening procedure;sex;Sex Differences;side effect;stem cell biology;stem cells;Structure;System;Technology;Therapeutic;therapeutic target;Time;Tissues;Titrations;Torsades de Pointes;Training;translational impact;translational medicine;Translational Research;virtual screening;Woman;women patients;Work;Youth

PROJECT_TITLE: The Effects of Estrogen on Cardiac Arrhythmic Propensity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative / Public Health Relevance Our brain’s ability to generate decisions can be severely disrupted by psychiatric disorders, such as anxiety, depression, bipolar disorder, and obsessive compulsive disorder. This proposal develops novel analytical and experimental approaches for understanding decision making at the level of populations of individual neurons in human and non-human primate premotor cortex, an area tightly linked to decision making. By integrating a large collection of new and existing datasets reflecting the involvement of premotor cortex in a wide range of decision- making tasks, the proposed research is expected to generate fundamental knowledge about unifying principles of decision-related neural computation, which may ultimately lead to improvements in the diagnosis and treat- ment of decision-impacting psychiatric conditions.

PI_NAMEs: GOLUB, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: analytical tool;Anxiety;Area;artificial neural network;Attention;Automobile Driving;Behavior;behavioral response;Bipolar Disorder;Brain;Collection;Color;Data;Data Collection;Data Set;Decision Making;Diagnosis;discrimination task;Dorsal;Ensure;experimental study;flexibility;Functional disorder;Goals;Human;Impairment;improved;Individual;innovation;Knowledge;Learning;learning network;Link;Mental Depression;Mental disorders;Modality;Modeling;Monkeys;Motion;Motor Cortex;multiple datasets;multitask;neural;neural circuit;neuromechanism;Neurons;neurophysiology;nonhuman primate;novel;Obsessive-Compulsive Disorder;Participant;Phase;Population;Population Dynamics;Process;public health relevance;recurrent neural network;Reporting;Research;response;Reverse engineering;Role;Sensory;Sensory Process;Speed;Stimulus;Structure;Techniques;Testing;Time;tool;Training;Variant

PROJECT_TITLE: Brain-wide neural population dynamics during decision making and learning


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Machine Learning and Artificial Intelligence;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: This proposal describes a comprehensive plan for the applicant, Dr. Jerod Rasmussen, to obtain expert training and conduct research that aims to identify novel MRI-based measures of energy homeostasis-related brain circuitry in the human newborn, identify their gestational biology determinants, and determine the prospective association of these measures with subsequent risk for childhood obesity. The identification of brain-related biomarkers of childhood obesity risk that predate the influence of the obesogenic environment will contribute to an improved understanding of the neurological underpinnings of obesity, early identification of at-risk individuals, and intervention targets for primary prevention.

PI_NAMEs: RASMUSSEN, JEROD MICHAEL (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Adipose tissue;Age;analytical method;Anatomy;Back;Biological Markers;Biology;Birth;Body mass index;Brain;brain circuitry;Brain imaging;brain magnetic resonance imaging;Breathing;career;career development;Cerebrum;Chemical Shift Imaging;Cholesterol;clinically significant;cohort;connectome;cost effective;Data;data reduction;design;Development;Developmental Biology;developmental plasticity;Diet;Diffusion Magnetic Resonance Imaging;Disease;disorder risk;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Early identification;Endocrine;Endocrine system;energy balance;Enrollment;Environment;Equilibrium;Etiology;Exhibits;Fatty acid glycerol esters;fetal;fetal programming;Functional Magnetic Resonance Imaging;Funding Mechanisms;Genetic Risk;Gestational Age;gestational weight gain;Glucose;Graph;gray matter;Growth;Health;High Density Lipoproteins;Homeostasis;Human;Hydrocortisone;Hypothalamic structure;Immune;Immune system;improved;Individual;Individual Differences;infancy;Infant;infant adiposity;Inflammatory;Insulin;Interleukin-6;Intervention;Knowledge;Life;Lipids;Logic;Machine Learning;Magnetic Resonance Imaging;Maternal-fetal medicine;Measures;Mediating;Mentors;Mentorship;Metabolic;metabolic rate;Methods;Modeling;neuroimaging;Neurologic;Neurosciences;newborn adiposity;Newborn Infant;Nonesterified Fatty Acids;novel;Obesity;obesity in children;obesity risk;obesogenic;obstetrical complication;Outcome;Phase;Phenotype;Physics;Physiological;population based;postnatal;predictive modeling;Pregnancy;prenatal;prenatal stress;prepregnancy;Primary Prevention;Principal Component Analysis;Procedures;Process;programs;prospective;Public Health;random forest;recruit;Research;Research Proposals;Rewards;Risk;Risk Factors;Role;Satiation;Scientific Advances and Accomplishments;sex;Shapes;skills;Standardization;Surface;System;Technology;Term Birth;Testing;Time;TNF gene;Training;Triglycerides;Validation;Variant;vector;Weight;white matter

PROJECT_TITLE: Fetal Programming of Human Newborn Energy Homeostasis Brain Networks


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Molecular mechanisms of intersecting human telomeric functions Narrative Telomeres are structures found at the ends of our chromosomes that are instrumental in ensuring the integrity of our genomes. This proposal aims to understand at a molecular level how human telomeres help maintain chromosome ends in different biological contexts, including in cancer cells, stem cells, and cells undergoing meiosis. These studies will enhance our knowledge of how telomeres uphold genome integrity and help develop strategies to counter telomere dysregulation in human diseases like cancer and infertility.

PI_NAMEs: NANDAKUMAR, JAYAKRISHNAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Binding;Biochemical;Biochemistry;Biological;cancer cell;Cell Proliferation;Cells;Cellular biology;Chromosomes;Complex;Crystallography;Cytoskeleton;Disease;DNA;DNA Damage;Ensure;Enzymes;Functional disorder;Genetic Crossing Over;Genome;genome integrity;Germ Cells;Human;human disease;Infertility;Knowledge;Malignant Neoplasms;Meiosis;Molecular;novel therapeutic intervention;novel therapeutics;Nuclear Envelope;Pathway interactions;Process;Production;protein complex;Proteins;recruit;Ribonucleoproteins;RNA;S phase;Somatic Cell;stem cells;Structure;Telomerase;telomere;Telomere Recombination;Testing;Therapeutic;therapeutic development

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: NARRATIVE Poor motor and cognitive function are related to AD and related pathologies (ADRD), but despite the accumulation of these pathologies in their brains, some older adults exhibit little loss of function. This study will identify and validate resilience proteins in older adults which may offset the effects of ADRD pathologies that accumulate in older brains. This work is timely as it will provide novel targets for further drug studies that can yield treatments to maintain motor and cognitive function in millions of older Americans.

PI_NAMEs: BUCHMAN, ARON S (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;American;Area;Attention;Behavior;Biological Markers;Brain;Brain region;Brain Stem;Cognitive;cognitive ability;cognitive function;Complement;Data;decrease resilience;Dementia;disability;disease phenotype;Dorsal;drug discovery;Drug Targeting;Exhibits;gene discovery;Genes;Horns;Impaired cognition;indexing;Individual Differences;Lateral;Link;link protein;Loneliness;loss of function;Measures;Memory;modifiable risk;Monitor;Motor;Motor Neurons;Movement;Muscle;Nerve;neural;novel;older adult;Pathology;Persons;Pharmaceutical Preparations;pre-clinical;Prefrontal Cortex;prevent;Proteins;Proteomics;Public Health;Publishing;quadriceps muscle;Reaction;resilience;Resources;Risk Factors;Sampling;social;Specificity;Spinal;Spinal Cord;System;Systems Biology;Testing;Tissues;transcriptome;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Identifying resilience proteins in key motor tissues that drive motor and cognitive decline and offset the negative effects of ADRD pathologies within and outside the brain


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Evidence suggests a role for pro-angiogenic macrophages in neovascular age-related macular degeneration pathogenesis, but currently there are no therapies to specifically target these cells. Our preliminary data demonstrates that beta-adrenergic receptor antagonism inhibits laser- induced choroidal neovascularization by reducing interleukin-6 expression in macrophages. We aim to dissect the beta-adrenergic receptor -> interleukin-6 -> angiogenesis pathway, and to determine how beta-adrenergic receptor inhibition influences the transcriptional profile of macrophages in order to identify new therapeutic targets that will inhibit macrophage-driven angiogenesis.

PI_NAMEs: LAVINE, JEREMY A (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adrenergic Antagonists;Adrenergic Receptor;Affect;angiogenesis;Angiogenesis Inhibitors;Angiogenesis Pathway;antagonist;Anti-Inflammatory Agents;Area;Award;Basic Science;beta-adrenergic receptor;Bioinformatics;Biology;Blindness;Cancer Center;Cardiovascular system;career;career development;cell type;Cells;Cellular biology;cellular targeting;Choroidal Neovascularization;Clinical;clinical training;Collaborations;cytokine;Data;Development Plans;Disease;Doctor of Philosophy;Educational process of instructing;Endothelial Cells;expectation;Exudative age-related macular degeneration;Eye;Fellowship;Flow Cytometry;Foundations;functional genomics;Funding;Future;Gene Expression Profile;Genotype;Goals;Growth Factor Inhibition;Immunology;in vivo;individualized medicine;Inflammation;Inflammatory;Innate Immune System;innovation;Interleukin 6 Receptor;Interleukin-6;Laboratories;Lasers;Liquid substance;Lung;Macrophage;Measures;Mentors;Mentorship;Molecular Target;monocyte;mouse model;Mus;Natural Immunity;Neomycin resistance gene;new therapeutic target;novel;Ophthalmology;Pathogenesis;Patients;Persons;Phase;Phenotype;Physicians;Productivity;professor;programs;receptor;receptor expression;Receptor Inhibition;Receptor Signaling;recruit;Reporter;Research;Research Institute;Research Personnel;Residencies;Resistance;response;Retina;Rheumatology;Role;Scientist;Signal Transduction;skills;Sorting;Specialist;Spider nevus;standard of care;Surgeon;targeted treatment;Techniques;Testing;therapeutic target;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Treatment Factor;Universities;Up-Regulation;Vascular Endothelial Growth Factors;Vision;Work

PROJECT_TITLE: The role of beta2-adrenergic receptor and interleukin-6 signaling in macrophage-driven choroidal neovascularization