NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE There are no effective treatments for perianal fistula (PAF), which occurs in up to 40% of Crohn’s disease pa- tients. This proposed study aims to develop a biostimulatory nanofiber-hydrogel composite plug to promote tissue healing and test its efficacy to repair PAF in rodent and swine models in conjunction with adipose-de- rived stem cells (ADSCs) or ADSC-derived exosomes. If successful, this study will offer a translatable off-the- shelf biomimetic NHC microporous plugs for PAF repair and tissue healing.

PI_NAMEs: MAO, HAI-QUAN  (contact);SELARU, FLORIN

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: adipose derived stem cell;Age;American;Anal Fistula;angiogenesis;Animal Model;Anus;Biocompatible Materials;Biological Response Modifier Therapy;Biology;Biomimetics;caprolactone;Caring;Cell Adhesion;cell motility;Cells;Characteristics;Clinical;clinical translation;clinically relevant;Collagen;Communication;Complication;conditioning;covalent bond;Crohn's disease;Deposition;Development;Devices;Diagnosis;Drainage procedure;effective therapy;efficacy evaluation;Elasticity;Engineering;exosome;Extracellular Matrix;fabrication;Family suidae;Fecal Incontinence;Fistula;Foundations;Fright;Funding;Future;Generations;Goals;healing;high risk;Hyaluronic Acid;Hydrogels;immunoregulation;Impairment;implantation;improved;In Vitro;in vivo;Incidence;Infection;Infiltration;Inflammatory Bowel Diseases;Inflammatory Response;Injectable;Injections;Kinetics;Lead;mechanical properties;Mechanics;migration;Modeling;nanofiber;novel;Operative Surgical Procedures;Outcome;Pain;Patients;Polyesters;porcine model;Porosity;Process;Property;Protocols documentation;Quality of life;Rattus;Rectum;regenerative;repaired;Reproducibility;research clinical testing;response;restoration;Rodent Model;Series;Site;Skin;soft tissue;stem cell exosomes;stem cell therapy;Structure;Structure-Activity Relationship;success;Surgical sutures;synergism;Testing;Tissues;translational potential;Vascularization;Work

PROJECT_TITLE: A nanofiber-hydrogel composite plug for perianal fistula repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Malaria is one of the world’s most devastating infectious diseases, causing greater than 400,000 deaths per year and primarily impacting young children living in sub-tropical and tropical regions. Key to the virulence of the deadliest malaria parasite, Plasmodium falciparum, is its ability to evade the human immune system. This proposal seeks to understand the mechanisms by which this parasite can escape our natural immune responses and will aid in the developments of new approaches to reduce the impact that this disease has on the world.

PI_NAMEs: VISONE, JOSEPH EDWARD (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Accounting;adaptive immune response;Amino Acids;antibody detection;Antigenic Variation;Assessment tool;Binding;Biology;Blood Vessels;Cessation of life;Child;Communicable Diseases;Complement;CRISPR/Cas technology;Culture Media;Data;design;Detection;Development;Disease;Endothelium;Epigenetic Process;Erythrocyte Membrane;Erythrocytes;Eukaryotic Initiation Factor-2;Expenditure;experience;Exposure to;Flow Cytometry;Gene Activation;Gene Family;Gene Silencing;Genes;genetic manipulation;Genetic Transcription;Genome;global health;Human;Immune Evasion;Immune response;Immune system;immunogenic;Immunologics;Individual;Infection;Initiator Codon;Integral Membrane Protein;Introns;Knock-out;Malaria;malaria infection;mathematical algorithm;Mediating;member;Messenger RNA;Mission;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;mRNA Stability;National Institute of Allergy and Infectious Disease;Nonsense Codon;Nonsense-Mediated Decay;novel strategies;Nutrient;Nutrient Depletion;Open Reading Frames;parasite genome;Parasites;pathogen;Pathway interactions;Peptide Initiation Factors;Phenotype;Phosphorylation;Phosphotransferases;Placenta;Plasmodium falciparum;Play;Pregnancy;premature;prevent;Process;Protein Isoforms;Proteins;Quantitative Reverse Transcriptase PCR;Reaction;receptor;Regulation;Reporter;response;Role;Spleen;Stress;Surface;Switch Genes;System;Terminator Codon;Testing;Time;Transcript;Transcriptional Activation;Transcriptional Regulation;Translation Initiation;Translations;Virulence

PROJECT_TITLE: A Molecular Switch Controlling Antigenic Variation in Malaria Parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Contraception/Reproduction;Dementia;Estrogen;Hypertension;Menopause;Neurodegenerative;Neurosciences;Nutrition;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: MOSTANY, RICARDO  (contact)

PROJECT_TERMS: Affect;Age;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Animals;arteriole;awake;barrel cortex;Behavior;Biological Availability;Blood Vessels;Brain;brain cell;cardiometabolism;Cardiovascular system;Cells;Cerebrovascular system;Chronic;Cognition;Cognitive;Cognitive aging;comorbidity;Dementia;design;discrimination task;Early Intervention;effective therapy;Electron Spin Resonance Spectroscopy;Electrophysiology (science);Equilibrium;Estradiol;Estrogens;excitatory neuron;experience;Female;Frequencies;Genus Hippocampus;Health;High Fat Diet;high risk;High Risk Woman;hippocampal pyramidal neuron;hormone therapy;Hormone use;Hormones;Hypertension;Image;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Information Management;inhibitory neuron;interdisciplinary approach;Interneurons;Intervention;Knowledge;lifetime risk;Mediating;men;Menopause;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Microscopy;midlife estradiol;Midlife women;Mitochondria;Molecular;Mus;neural;Neurons;neuroprotection;neurovascular coupling;Nitric Oxide;NOS3 gene;novel;Obesity;Outcome;Ovariectomy;Patients;Penetration;Performance;Perfusion;Perimenopause;Periodicity;Peroxonitrite;personalized intervention;pharmacologic;Postmenopause;preservation;Prevalence;prevent;Probability;Production;protective effect;Reporting;Respiration;response;restoration;Risk;Role;Sensory;Sleep disturbances;Somatosensory Cortex;structural imaging;Synapses;Synaptic plasticity;Testing;Texture;Therapeutic Intervention;two-photon;Vascular blood supply;Vascular Dementia;Vasomotor;Vibrissae;Woman

PROJECT_TITLE: Impact of hypertension and high-fat diet on mechanisms by which estradiol affects cortical synaptic plasticity.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Elderly surgical patients are at extremely high risk for cognitive and functional decline after hospitalization, but individual interventions to reduce this decline (e.g., anesthesia/sedation strategies, mobilization, rehabilitation) have exhibited limited success. An extensive program combining physical and cognitive training prior to, during, and after hospitalization has not yet been evaluated. The COPE-iOS study will examine whether a comprehensive program of computerized cognitive training, guided progressive physical exercise, and health education performed throughout the entire perioperative period will improve long-term cognitive and disability outcomes in elderly surgical patients at high risk for decline.

PI_NAMEs: HUGHES, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: active control;Activities of Daily Living;Acute;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anatomy;Anesthesia procedures;Attention;Biological Markers;Blood;Blood brain barrier dysfunction;blood-brain barrier function;Brain;cerebral atrophy;Clinical;Cognition;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cognitive rehabilitation;cognitive training;computer game;computerized;Computers;Critical Illness;Data;Delirium;Dementia;disability;Disability outcome;Elderly;Endothelium;Evaluation;Exercise;Exhibits;frailty;functional decline;functional disability;Functional Magnetic Resonance Imaging;functional outcomes;functional status;Habilitation;Health education;high risk;Hospitalization;Hospitals;Impaired cognition;improved;improved outcome;Individual;Injury;Intervention;Lead;Life;Link;Medical;Memory;Mental Depression;mind/body;multitask;neuroimaging;older adult;Older Population;Operative Surgical Procedures;Outcome;Patients;Perioperative;Physical Exercise;Physical Function;Physical Rehabilitation;Physical therapy;Plasma;Population;Postoperative Period;preservation;prevent;Process;processing speed;programs;Public Health;Quality of life;Randomized;Recommendation;Rehabilitation therapy;Reporting;Research;response;Sedation procedure;stressor;Subgroup;success;Survivors;Testing;Time;Training;Training Programs;United States National Institutes of Health;white matter

PROJECT_TITLE: Cognitive and Physical Exercise to Improve Outcomes after Surgery in the Elderly


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Precision Medicine;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This Administrative Resource Core of the consortium Integrative Neuroscience Initiative on Alcoholism: Stress and Chronic Alcohol Interactions (a.k.a. INIAstress) will provide oversight, direction and coordination of the 8 research projects and 2 research cores that collectively address brain circuitry and mechanisms underlying the reciprocal relationship of chronic alcohol and stress reactivity, with the overall goal of identifying new targets for effective pharmacotherapies to treat alcohol use disorders.

PI_NAMEs: GRANT, KATHLEEN A (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;Address;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol measurement;alcohol research;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;allostasis;Amygdaloid structure;animal data;Animal Model;Anxiety;anxiety states;anxiety-like behavior;Arousal;Behavioral;Behavioral Model;Brain;brain circuitry;brain magnetic resonance imaging;Brain Stem;Chronic;Cognitive;Collection;Communities;comorbidity;Consumption;Corpus striatum structure;Data;Development;Diagnostic;drinking;effective therapy;Endocrine;Ethanol;executive function;Exposure to;flexibility;forging;Functional Imaging;Gene Activation;Genetic;Genetic Techniques;Goals;Grant;hazardous drinking;Heavy Drinking;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impairment;indexing;Individual;Individual Differences;individualized medicine;innovation;Knowledge;Lead;Leadership;Link;longitudinal design;Mediating;Memory;Motivation;multidisciplinary;negative emotional state;neural;neural circuit;neuroadaptation;neuromechanism;Neurons;Neurosciences;Neurotransmitters;Output;Perception;personalized medicine;Pharmacotherapy;Physiological;Predisposition;Prevention;Process;Recovery;Relapse;Research;Research Activity;Research Project Grants;Resources;response;Risk;sensor;Sensory;social;Spectrum Analysis;Stress;stress reactivity;stress related disorder;stress state;Stressful Event;stressor;Structure;System;Techniques;Technology;Time;treatment strategy

PROJECT_TITLE: 1/1 INIA Stress and Chronic Alcohol Interactions: Administrative Resource


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Estrogen;Heart Disease;Hypertension;Menopause;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: LINDSEY, SARAH H. (contact)

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Angiotensin II;Animal Model;Anti-Hypertensive Agents;arterial stiffness;Attenuated;blood damage;Blood Pressure;Blood Vessels;Brain;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular effects;Cardiovascular system;Chronology;Cognition;Cognitive;Cognitive aging;cognitive function;Collaborations;Complement;dementia risk;design;Development;Disease;Disease Progression;Early Diagnosis;Enrollment;ESR1 gene;Estradiol;Estrogen decline;Estrogen Receptors;Estrogens;experimental study;Female;Genetic;Goals;GPER gene;grasp;Health;hormone therapy;Hormones;Hypertension;Impaired cognition;improved;in vivo;innovation;Knowledge;Laboratories;Laboratory Finding;Lead;Life;Long-Evans Rats;Luciferases;menopausal hormone therapy;Menopause;Methods;middle age;Modeling;Molecular;Monitor;mouse model;Mus;neurovascular coupling;novel;Nurses' Health Study;older patient;Organ;Ovariectomy;Perimenopause;Pharmaceutical Preparations;Pharmacology;Postmenopause;pre-clinical;programs;protective effect;Publications;receptor;receptor expression;receptor function;Regulation;Research Personnel;Research Project Grants;Resolution;response;Rodent Model;Role;Signal Pathway;Techniques;Time;Transcript;Transgenic Mice;Transgenic Organisms;ultrasound;Vascular Dementia;Vertebral column;Woman;Women's Health

PROJECT_TITLE: Impact of estradiol on vascular health and subsequent implications for cognitive aging.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Contraception/Reproduction;Dementia;Diabetes;Estrogen;Menopause;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: ZSOMBOK, ANDREA  (contact)

PROJECT_TERMS: Address;Age;Alzheimer's Disease;Alzheimer's disease patient;Animal Model;Animals;Attenuated;Autonomic Dysfunction;behavior test;blood glucose regulation;Blood Pressure;Body Composition;Body Weight;Brain;cardiometabolism;Cells;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;Data;Dementia;Dementia with Lewy Bodies;Diabetes Mellitus;Diabetes prevention;dietary control;Energy Metabolism;Estradiol;Estrogen Receptors;Estrogen Therapy;Estrogens;Failure;Female;Glucose;glucose production;glucose tolerance;glucose uptake;glycemic control;Health;High Fat Diet;hippocampal pyramidal neuron;Hippocampus;Homeostasis;hormone therapy;Hypothalamic structure;Impaired cognition;Impairment;improved;Insulin;Insulin Resistance;insulin sensitivity;Learning;Link;Liver;Long-Term Potentiation;Memory;menopausal hormone therapy;Menopause;Metabolic;Metabolism;middle age;midlife estradiol;mild cognitive impairment;mouse model;Mus;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Ovariectomy;Ovary;paraventricular nucleus;patch clamp;Pathway interactions;Patients;PIK3CG gene;Play;Postmenopause;Prevalence;Property;Receptor Signaling;Regulation;Risk;Risk Factors;Rodent;Role;Signal Pathway;spatial memory;Sympathetic Nervous System;Synapses;Synaptic plasticity;Testing;Tissues;Tracer;treatment comparison;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Dementia;Viral;Woman

PROJECT_TITLE: Impact of estradiol on the central regulation of glucose homeostasis and subsequent implications for hippocampal function.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: The Vanderbilt Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes (VMPMOD) advances knowledge of diabetes, obesity, and related disorders by providing state-of-the-art phenotyping services to the scientific community. Access to the services of the VMPMOD broadens the scope, expedites the completion, improves the quality, and reduces the overall costs of research for investigators nationally.

PI_NAMEs: AYALA, JULIO E (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Animals;bariatric surgery;base;Behavioral;biological research;Blood specimen;Body Weight;Brain region;Cannulations;Carbohydrates;Catheters;Communities;Complications of Diabetes Mellitus;Conscious;Controlled Environment;cost;data management;Dedications;design;Development;Diabetes Mellitus;Diabetic mouse;Diet;Disease;drinking water;Education;Education and Outreach;Eligibility Determination;energy balance;Ensure;Exercise;experience;experimental study;Faculty;Fatty acid glycerol esters;Feedback;Fiber;Fiber Optics;flexibility;Foundations;Funding;gene environment interaction;Genetic;Genetic study;Glucose Clamp;Goals;Guidelines;Health;Health Services Accessibility;Hormone secretion;Hypoglycemia;implantation;improved;Indirect Calorimetry;Infrastructure;Infusion procedures;Injections;innovation;Institution;Insulin;Islets of Langerhans Transplantation;Knowledge;Lead;Leadership;Learning;life span;Measurement;Medical Research;meetings;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Methodology;Methods;Mission;Modeling;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;neuroregulation;novel;Obesity;optogenetics;outreach;outreach program;oxidation;pharmacologic;Phenotype;Photometry;Physical activity;Physiological;Physiology;Population;Procedures;programs;Protocols documentation;Recording of previous events;Regulation;Research;Research Personnel;Resources;respiratory;response;Sampling;Scholarship;Scientist;Secure;Services;skills;solute;Standardization;success;surgical service;targeted delivery;Techniques;Technology;telemetering;Testing;tool;treadmill;Underrepresented Populations;Venous;Viral;welfare;Work


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PI_NAMEs: WASSERMAN, DAVID H (contact)

PROJECT_TERMS: Abbreviations;Achievement;Advisory Committees;animal care;Animals;Area;Back;Basic Science;Benchmarking;Biophysics;Body Weight;career;Charge;Clinical;cohesion;Communities;Consultations;Data;data management;Department chair;Development;Diabetes Mellitus;Education;Education and Outreach;Eligibility Determination;Ensure;equity, diversity, and inclusion;Evaluation;experience;expiration;Faculty;Funding;Goals;Guidelines;Health;Home;Human Resources;improved;Infrastructure;Institution;Leadership;medical schools;meetings;member;Metabolic;metabolic phenotype;Modeling;Molecular;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;operation;outreach;outreach program;Persons;Physiology;Policies;Population;Positioning Attribute;Procedures;Productivity;programs;Recommendation;Recording of previous events;Regulation;Reproducibility;Research;research and development;Research Personnel;Resources;Sampling;Schedule;Scholarship;Services;success;Surveys;synergism;Testing;tool;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;welfare

PROJECT_TITLE: Administrative


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: RELEVANCE Alcohol use disorder is a major health concern that exacts significant social and economic burden on the United States, and stress significantly contributes to this problem. This research project aims to enhance our understanding about brain mechanisms and circuits that underlie the ability of stress to further increase alcohol drinking, trigger relapse, and exacerbate impaired ability to engage behavioral flexibility that would serve to dampen stress-alcohol interactions. The overall goal is to use this knowledge to facilitate development of new and more effective interventions for treating stress-related excessive alcohol drinking, and alcohol use disorder in general.

PI_NAMEs: BECKER, HOWARD C. (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Address;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;antagonist;Area;Behavior;behavior measurement;Behavioral;behavioral impairment;Brain;Choice Behavior;Chronic;Chronic stress;Complex;Consumption;CRISPR/Cas technology;Data;Development;Disinhibition;drinking;Dynorphins;Economic Burden;effective intervention;Ethanol;flexibility;Funding;Genetic;genetic manipulation;Goals;Health;Hypothalamic structure;Impairment;individual variation;Infusion procedures;Injections;insight;Internal Ribosome Entry Site;kappa opioid receptors;Knowledge;Mediating;Modeling;mouse model;Mus;neural circuit;Neurons;Neuropeptides;Odors;Operant Conditioning;Outcome;Outcome Measure;Oxytocin;Oxytocin Receptor;Pathway interactions;Peptides;pharmacologic;Pilot Projects;Population;Predisposition;Procedures;Quinine;Receptor Signaling;Relapse;Research Project Grants;response;Rewards;Role;Self Administration;Sex Differences;Signal Transduction;social;Stress;stress management;stress reduction;stressor;Sucrose;Swimming;System;Testing;Time;Transgenic Mice;United States;Viral;Work

PROJECT_TITLE: 1/8: INIA Stress and Chronic Alcohol Interactions: Role of Dynorphin/KOR and Oxytocin Systems in Stress-Enhanced Alcohol Drinking, Relapse, and Impaired Behavioral Flexibility


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Based on our preliminary data, activation of oncogenic Kras in the pancreas leads to expansion and reprogramming of myeloid cells that in turn promote carcinogenesis. Conversely, upon inactivation of oncogenic Kras, the pancreas undergoes tissue repair, a process that is accompanied by and requires myeloid cells as well. The major goals of this project are to longitudinally characterize myeloid cell evolution during pancreatic carcinogenesis in mice and human patients and dissect mechanisms of myeloid cell-driven carcinogenesis.

PI_NAMEs: FRANKEL, TIMOTHY LOUIS;PASCA DI MAGLIANO, MARINA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acceleration;Acinar Cell;advanced disease;anti-tumor immune response;Architecture;Autopsy;cancer cell;Cancer Etiology;cancer invasiveness;carcinogenesis;CCR1 gene;cell dedifferentiation;cell preparation;Cell Separation;Cells;Cessation of life;chronic pancreatitis;Cytokine Receptors;Data;Dependence;Development;Diphtheria Toxin;Disease;disease model;Duct (organ) structure;Elements;Epithelial Cells;Epithelium;Evolution;Excision;Exposure to;Fibroblasts;functional status;Genes;genetic approach;Genetically Engineered Mouse;Goals;granulocyte;high risk;high risk population;Human;human tissue;Immune;immune cell infiltrate;Impairment;in silico;In Vitro;in vivo;Indolent;Inflammation;Knowledge;KRAS oncogenesis;KRAS2 gene;Lead;Lesion;Link;Macrophage;Maintenance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Maps;Mediating;mouse model;Mus;mutant;Mutation;Myeloid Cells;neoplastic;neoplastic cell;Neoplastic Cell Transformation;new combination therapies;Non-Malignant;novel strategies;Oncogenic;Operative Surgical Procedures;Organ Donations;Organ Donor;Organoids;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer model;Pancreatic Intraepithelial Neoplasia;pancreatic tumorigenesis;Pancreatitis;Pathway interactions;Patients;Penetrance;pharmacologic;polarized cell;Population;Predisposition;Preneoplastic Conditions;prevent;Process;programs;Proliferating;Publishing;Recurrence;Reproducibility;Residual state;Risk;Role;Sampling;Scheme;Signal Transduction;stem-like cell;System;T-Cell Activation;T-Lymphocyte;Testing;therapeutic development;tissue repair;Tissues;tumor;tumor growth;tumor initiation;Tumor Markers;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;United States

PROJECT_TITLE: Mechanisms of myeloid cell driven pancreatic plasticity and carcinogenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Despite recommendations for annual HIV screening among adolescents, testing rates among adolescent sexual minority males, transgender girls, and gender diverse teens (ASMM/TGD) are extremely low, and interventions specifically aimed at increasing adolescent testing rates are scarce. This proposal aims to test the effectiveness of a text message-based intervention on HIV testing behaviors and investigate factors that may facilitate widespread implementation of such programs among ASMM/TGD. Ultimately, increased HIV testing in this group will mitigate transmission rates and improve the HIV prevention and care continua in this population.

PI_NAMEs: MACAPAGAL, KATHRYN ROSE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Accounting;active method;Address;Adolescent;Adoption;Adult;Affect;Age;age group;aged;AIDS prevention;antiretroviral therapy;arm;Attention;behavior change;behavior test;Behavioral;Bisexual;boys;Caring;cisgender;Clinic;Collaborations;Communities;Computer software;Consensus;Consolidated Framework for Implementation Research;Continuity of Patient Care;design;Development;Devices;digital;digital health;digital intervention;digital technology;effective intervention;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation design;Ensure;Epidemic;Focus Groups;follow-up;forging;Gays;Gender;gender diverse;gender minority youth;Generations;girls;Goals;group intervention;Health Personnel;healthy lifestyle;High School Student;HIV;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;hybrid type 1 trial;Hybrids;implementation barriers;implementation science;improved;Incidence;Infection;innovation;Intervention;Intervention Trial;Interview;Left;Mediator;Minority;Modeling;Modernization;Motivation;Outcome;Population;pre-exposure prophylaxis;preference;prevent;Prevention;Prevention program;Prevention Research;preventive intervention;primary outcome;Process;programs;prospective;Provider;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resources;Risk;Risk Reduction Behavior;scale up;Science;screening;secondary outcome;Self Efficacy;Service provision;sexual minority male;sexual minority youth;sexually active adolescent;skills;social media;software development;Strategic Planning;success;Surveys;Technology;Teenagers;Test Result;Testing;Text Messaging;text messaging intervention;therapy design;Time;tool;transgender;transmission process;treatment arm;Unsafe Sex;Update;uptake;Youth

PROJECT_TITLE: Effectiveness and implementation of text messaging to improve HIV testing in sexual and gender minority adolescents

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Type-2 diabetes mellitus (T2DM) is associated with faster cognitive decline in aging and a higher risk of developing Alzheimer’s disease. The objective of this project is to aid public health by identifying markers of the brain changes in T2DM that are associated with cognitive impairment with the hope that these markers could be used to develop new clinical treatments.

PI_NAMEs: FRIED, PETER J (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;Affect;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Amyloid beta-Protein;apolipoprotein E-4;Atrophic;biomarker identification;Blood Vessels;blood-brain barrier disruption;Brain;brain behavior;brain health;brain metabolism;Brain region;cerebral atrophy;Clinical;Clinical Treatment;Cognition;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cognitive testing;comparison control;Data;Dementia;dementia risk;Diabetes Mellitus;Electroencephalography;Electromyography;Etiology;Evaluation;executive function;Foundations;Funding;Glucose;Glutamate Metabolism Pathway;Glutamates;Glycosylated hemoglobin A;Goals;Health;high risk;Human;human old age (65+);Hypoglycemia;Impaired cognition;impaired glucose tolerance;Impairment;in vivo;indexing;Inferior;Insulin Resistance;Intervention;Knowledge;Link;Lobule;Long-Term Potentiation;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Mediation;Memory;Metabolic;Metabolism;Motor Cortex;Motor Evoked Potentials;N-Methyl-D-Aspartate Receptors;neurobiological mechanism;Neurocognitive;Neurologic;Neuronal Plasticity;neurophysiology;Neuropsychological Tests;neurotoxicity;neurotransmission;new therapeutic target;non-demented;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;older adult;older patient;Output;Parietal;Parietal Lobe;Participant;Patients;Physiologic pulse;Plasma;Prediabetes syndrome;Prefrontal Cortex;Protocols documentation;Public Health;recruit;repetitive transcranial magnetic stimulation;response;Risk Factors;Risk Reduction;Rodent Model;Role;Site;Specificity;Subgroup;Synapses;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Thick;Transcranial magnetic stimulation;Translating;United States National Institutes of Health;white matter;Work

PROJECT_TITLE: Neurobiological mechanisms of altered cortical plasticity in Type-2 diabetes mellitus

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


PI_NAMEs: YU, ERIN  (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Accreditation;Admission activity;animal care;Animal Welfare;Animals;Basic Science;Caring;Certification;cohort;Comparative Pathology;cost;Data;Diabetes Mellitus;dietary requirement;disease diagnosis;Doctor of Philosophy;Documentation;Ensure;experimental study;Goals;Guidelines;Health;Institution;International;Laboratory Animals;Link;Maintenance;medical schools;metabolic abnormality assessment;metabolic phenotype;Modeling;Mus;Nature;novel;Obesity;operation;Pathologic;Pathology;Performance;Phenotype;Procedures;programs;Protocols documentation;Quarantine;Records;Research;Resource Sharing;Resources;Services;Stress;success;Testing;United States Department of Agriculture;Universities;Variant;welfare;Work

PROJECT_TITLE: Animal Health and Welfare


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Burns are a common type of trauma that affects approximately 2 million Americans each year. A major cause of mortality in patients with major burns is injured tissue releasing cell death products into the blood to cause small blood vessel leakage. This project investigates the role and mechanisms of increased plasma histones as major cell death products that disrupt blood vessel integrity, with the goal to identify new therapeutics for treating burns.

PI_NAMEs: WU, MACK H (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Affect;American;Animals;Anti-Inflammatory Agents;Antibiotics;Attenuated;Binding;Biological Assay;Blood;Blood specimen;Blood Vessels;Burn injury;burn therapy;C Type Lectin Receptors;Cannulations;Cell Death;cell injury;Cell model;Cell Nucleus;Cells;Cellular biology;Cessation of life;Characteristics;Chromatin;Circulation;comparative;Confocal Microscopy;Cultured Cells;Cutaneous;cytokine;Data;design;Development;Edema;Endothelium;Environment;experimental study;extracellular;Extracellular Space;Extravasation;Failure;Fluid Therapy;Focal Adhesions;Functional disorder;Goals;healthy volunteer;Histamine;Histones;Hour;Human;human subject;Hypertension;Imaging Techniques;Immune Targeting;Immunity;in vivo;in vivo evaluation;Incineration;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;innovation;insight;Intercellular Junctions;Intra-abdominal;Knowledge;Life;Lipids;Lung;Mediating;Mediator;Mesentery;Microcirculation;Molecular;Molecular Conformation;monolayer;mortality;mouse model;Mus;nanoimaging;neutralizing antibody;novel;novel diagnostics;novel therapeutics;Nuclear;Nuclear Proteins;optoacoustic tomography;Organ;organ injury;Pathologic;Pathology;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phosphorylation;Plasma;Production;Protein Tyrosine Kinase;PTK2 gene;receptor;Receptor Signaling;Reporting;Research;respiratory distress syndrome;response;Role;Series;severe burns;Signal Pathway;Signal Transduction;Study Subject;Syndrome;systemic inflammatory response;Techniques;Testing;theories;tissue injury;Tissues;translational approach;translational study;Trauma;treatment strategy;ultra high resolution;Vascular Endothelial Cell;Vascular Endothelium;vascular injury;Visceral

PROJECT_TITLE: Extracellular Histones in Burn-induced Microvascular Hyperpermeability

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Kidney Disease;Lupus;Precision Medicine

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Lupus nephritis (LN) is a severe complication of lupus that can lead to kidney failure but for which current treatments are toxic and insufficiently effective. The goal of this proposal is to improve our understanding of what causes damage to the kidneys by studying a particular group of highly dynamic immune cells (myeloid cells) that are associated with poor outcome when they are found in kidney biopsy tissue of patients with LN. Myeloid cells can cause inflammation but can also help with tissue repair. Using new technologies that allow analysis of single cells we will construct an “atlas” of these cells in human and mouse LN, study their function in mouse LN models and determine what factors control their differentiation with the long-term goal of finding ways to target the harmful myeloid cells while retaining those that mediate protective functions.

PI_NAMEs: DAVIDSON, ANNE  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Aftercare;Animal Model;Antibodies;Antigen-Antibody Complex;Atlases;Attenuated;Autoantibodies;Autoimmune Diseases;Automobile Driving;belimumab;Biological;Biological Response Modifier Therapy;Biopsy;Blood;Cell Communication;Cell Compartmentation;Cell Physiology;Cells;Child;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complication;CRISPR library;cytokine;Data;Dendritic Cells;Deposition;design;Development;Diagnosis;Disease;Disease Progression;Disease remission;End stage renal failure;FDA approved;Fibrosis;Flare;Flow Cytometry;Frequencies;Functional disorder;Gene Silencing;Goals;Heterogeneity;Histologic;Homeostasis;Human;human data;human disease;human model;Immune;immune cell infiltrate;Immune system;Immunosuppressive Agents;Impairment;improved;In Vitro;in vivo;individual patient;Infiltration;Inflammation;Inflammatory;Injury to Kidney;interest;Intervention Studies;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Failure;Lupus;Lupus Nephritis;Macrophage;Maps;Mediating;Medicine;member;Methods;Modeling;Molecular Profiling;mouse model;Mouse Strains;Mus;Myelogenous;Myeloid Cells;Nephritis;new technology;new therapeutic target;novel therapeutic intervention;novel therapeutics;Organ;Outcome;outcome prediction;Pathogenicity;Pathway interactions;Patients;Peripheral;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiological;prevent;Prevention;Prognosis;programs;Protocols documentation;Remission Induction;Remission Induction Therapy;renal damage;Renal function;repair function;responders and non-responders;response;single cell analysis;single-cell RNA sequencing;standard of care;Stromal Cells;Systemic Lupus Erythematosus;Testing;Therapeutic immunosuppression;Therapeutic Intervention;therapeutic target;Time;tissue repair;Tissues;transcription factor

PROJECT_TITLE: Dissecting the heterogeneity and function of myeloid cells in lupus nephritis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Neurosciences;Nutrition;Obesity

PI_NAMEs: MCGUINNESS, OWEN P (contact)

PROJECT_TERMS: Abbreviations;Address;animal care;Animals;anterior chamber;bariatric surgery;Behavioral;Behavioral Mechanisms;Blood Vessels;Body Weight;Brain;Brain region;Cannulas;Cannulations;Carbon Dioxide;career;Catheterization;Catheters;Communities;Complex;Conscious;Consultations;Dedications;design;Development;Diabetes Mellitus;Education;energy balance;Energy Metabolism;Ensure;Exercise;exercise capacity;experience;Experimental Designs;experimental study;eye chamber;Facility Designs;Faculty;Feeding behaviors;Fiber Optics;flexibility;Floor;gene environment interaction;Gene Modified;Genetic;Genetic Models;Glucose Clamp;Hormones;Housing;human disease;Human Resources;Implant;implantation;in vivo;Indwelling Catheter;innovation;Institution;Insulin;inter-institutional;Investments;Islets of Langerhans Transplantation;Light;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;motivated behavior;mouse genetics;mouse model;Mus;neuroregulation;novel;nutrient metabolism;Obesity;Operative Surgical Procedures;Output;outreach;Oxygen;Participant;Physiological;Physiology;Population Heterogeneity;Procedures;programs;Recording of previous events;Regulation;Research;Research Personnel;Resources;Rewards;Role;sample collection;Scientist;Services;skills;Standardization;Stress;Surgeon;surgical service;Techniques;Technology;Time;Tissue Transplantation;tool;Training;Underrepresented Populations;uptake;Venous;Viral;Work

PROJECT_TITLE: Mouse Metabolic Physiology  Core


NIH_SPENDING_CATS: Biotechnology;Nutrition

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE STATEMENT Mitochondria are tiny engines that generate the chemical power that cells use to grow and function. This project aims to understand how an enzyme known as PDK4 helps mitochondria to maintain high rates of energy production in during normal stresses, such as food restriction and exercise. These studies will delineate the precise role of PDK4 in regulating fuel selection and use in tissues such as muscle and heart. The results could provide new approaches to treating metabolic disorders such as diabetes and heart disease.

PI_NAMEs: GRIMSRUD, PAUL A.;MUOIO, DEBORAH M (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Acute;Agreement;Animal Experiments;ATP Synthesis Pathway;Attention;Binding;Bioenergetics;blood glucose regulation;Body Composition;Carbon;Cardiac;Catabolism;Cells;Chemicals;Citric Acid Cycle;Consumption;Cues;Cultured Cells;Data;Diabetes Mellitus;diagnostic platform;Energy Metabolism;enzyme activity;Enzymes;Event;Exercise;experimental study;Exposure to;Family;Fasting;Fatty acid glycerol esters;Fatty Acids;flexibility;food restriction;gain of function;Generations;Genes;Genetic Engineering;Glucose;Glycolysis;Goals;Health Benefit;Heart;Heart Diseases;Human;Immunoprecipitation;improved;In Vitro;in vivo;innovation;Knock-out;knockout animal;Knockout Mice;Label;Laboratories;lead candidate;Ligands;Ligation;Lipids;Liver;loss of function;Malates;malic enzyme;Mass Spectrum Analysis;Mediating;member;Metabolic;Metabolic Diseases;metabolomics;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Molecular Profiling;mouse model;Mus;Muscle;Muscle Fibers;Myocardium;NADP;novel;novel strategies;Nutrient;oligomycin sensitivity-conferring protein;overexpression;oxidation;Oxidative Phosphorylation;PDH kinase;PDPK1 gene;Peroxisome Proliferator-Activated Receptors;Phosphopeptides;phosphoproteomics;Phosphorylation;Physiological;Physiological Adaptation;Play;Process;Production;Proteins;Proteomics;Pyruvate;Pyruvate Dehydrogenase Complex;pyruvate dehydrogenase kinase 4;Regimen;Regulation;Reporting;resilience;respiratory disorder diagnosis;Respiratory physiology;response;Role;Series;Serine;Site;Skeletal Muscle;Soleus Muscle;stable isotope;stem;Stress;Testing;therapeutic target;Thinness;Time-restricted feeding;Tissues;tool;Tracer;trafficking;transcription factor;Up-Regulation

PROJECT_TITLE: Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed project will seek to study the pathophysiology of chronic pancreatitis mediated by misfolded pancreatic triglyceride lipase mutants. We hope to fill the important knowledge gaps with respect to mechanisms driving chronic pancreatitis. Completion of the project will establish mutation-induced misfolding of pancreatic enzymes as a relevant disease mechanism in the pathogenesis of chronic pancreatitis and identify potential therapeutic targets to prevent or slow chronic pancreatitis.

PI_NAMEs: XIAO, XUNJUN  (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Age;age related;Animal Model;Animals;Apoptotic;Atrophic;Automobile Driving;Biological;Biological Assay;Cell Culture Techniques;Cell Death;Cells;Chinese;chronic pancreatitis;Complex;Data;Development;Disease;Disease Progression;early onset;end stage disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Ethanol;Event;Exhibits;feeding;Fibrosis;Functional disorder;gain of function;Genes;Genetic Predisposition to Disease;genetic risk factor;Goals;Human;human model;In Vitro;Induced Mutation;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Knowledge;Lipase;Measures;Mediating;misfolded protein;Modeling;mouse model;Mus;mutant;Necrosis;novel;novel therapeutic intervention;Onset of illness;Pancreas;Pancreatic enzyme;Pancreatic Injury;Pancreatitis;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;pre-clinical;Pre-Clinical Model;Predisposition;Prevalence;prevent;Process;protein degradation;Protein Isoforms;protein misfolding;Proteins;proteostasis;proteotoxicity;Recurrence;Research;response;Risk;Risk Factors;risk variant;Role;Signal Pathway;Signal Transduction;stem;targeted treatment;Testing;theories;Therapeutic;therapeutic target;therapy development;transcriptome sequencing;Trypsin;Trypsinogen;Variant;variant of interest;variant of unknown significance;Western Blotting

PROJECT_TITLE: Pathophysiology of Chronic Pancreatitis Associated with Misfolded PNLIP Risk Variants

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Prevention;Sleep Research;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Relevance Cancer is a common disorder; at some point during their lifetimes, one out of every three Americans will be diagnosed with cancer. Nearly 80% of cancer patients will experience either insomnia symptoms or insomnia disorder during chemotherapy. Insomnia is associated with numerous adverse health outcomes; it affects quality of life, contributes to fatigue, and may influence response to cancer treatments and survival. The proposed study will improve our understanding of insomnia pathophysiology and management in a clinical oncology community clinic.

PI_NAMEs: PALESH, OXANA G (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: acceptability and feasibility;actigraphy;Acute;adherence rate;Affect;Age;American;Attention;attenuation;Autonomic nervous system;Behavior Control;Behavior Therapy;Behavioral Paradigm;Benchmarking;Breast Cancer Patient;cancer care;Cancer Center;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;cancer type;chemotherapy;Chronic;circadian;Circadian Dysregulation;Circadian Rhythms;Clinic;Clinical;clinical care;Clinical Oncology;Clinical Research;Cognitive Therapy;Communities;community clinic;Community Clinical Oncology Program;community setting;Country;design;Development;Diagnosis;Disease;Education;Effectiveness;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Exclusion;experience;Fatigue;Functional disorder;Future;Gender;Health;Health Services Accessibility;Healthy Eating;heart rate variability;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;improvement on sleep;indexing;Infusion procedures;innovation;interest;Intervention;intervention effect;Learning;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediator;Medical;meetings;Melatonin;Mental disorders;Metastatic breast cancer;Methods;Modeling;Morbidity - disease rate;mortality;novel;novel strategies;Nurses;Nursing Research;Outcome;Pathway interactions;Patient Outcomes Assessments;Patients;Phase;phase II trial;Physical activity;Physiological;poor sleep;Private Practice;Prognostic Factor;programs;Psychophysiology;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Assistant;respiratory;response;Severities;side effect;Sinus Arrhythmia;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Sleeplessness;Stimulus;Survivors;Symptoms;Telephone;Testing;Time;Training;treatment response;Treatment-Related Cancer;Universities;Woman;Work

PROJECT_TITLE: Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: PROJECT NARRATIVE Public Health Relevance Statement  Pathologic dysregulation of the coagulation system is a major contributor to human morbidity and mortality, resulting in either excessive bleeding or clotting. While major improvements to human health have been made through advances in genetic technology and recombinant protein engineering, there are still a number of limitations to current diagnostics and therapeutics. The proposed studies will identify potential new diagnostics, therapies, and therapeutic targets, which will result in broadened treatment options for a diverse array of affected patients, enabling clinicians to tailor therapy to individuals with both hemostatic and thrombotic disorders.

PI_NAMEs: SHAVIT, JORDAN A (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Affect;Anticoagulants;Anticoagulation;Biological Assay;Blood Coagulation Disorders;Blood Coagulation Factor;blood product;Chemicals;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Diagnostic;Disease;experimental study;Family;Fishes;General Population;Genes;Genetic;Genetic study;genetic technology;Genome;genome editing;Health;Hemorrhage;Hemorrhagic Disorders;Hemostatic Disorders;Hemostatic function;high risk;Human;human morbidity;human mortality;improved;Individual;individualized medicine;innovation;Intravenous infusion procedures;Lead;Life;Mutagenesis;mutant;new therapeutic target;next generation sequencing;novel;novel diagnostics;novel therapeutics;nuclease;Oral;Pathologic;Pathology;Patients;Penetrance;prospective;Protein Engineering;public health relevance;Recombinant Proteins;Recombinants;Regulator Genes;Severities;Severity of illness;System;Therapeutic;Therapeutic Studies;therapeutic target;Thrombopoiesis;Thrombosis;thrombotic;tool;transcription activator-like effector nucleases;Work;Zebrafish

PROJECT_TITLE: Genetic and therapeutic studies of hemostatic and thrombotic disorders using zebrafish


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative/Public Health Relevance Adoptive cell transfer T cell immunotherapy has immense potential for treatment in several diseases, including cancer. Non-invasive quantitative imaging would be a powerful tool for evaluation of the impact of T cell modifi- cations and delivery routes, monitoring of off-target T cell accumulation, and stratification of groups of responders or non-responders to therapy on the basis of measures of T cell tumor accumulation. This project will pioneer non-invasive and quantitative tracking of adoptive T cell cancer immunotherapy using a new molecular imaging modality called magnetic particle imaging.

PI_NAMEs: RINALDI-RAMOS, CARLOS M (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Animals;Anisotropy;Benchmarking;Biodistribution;Biological Assay;biomaterial development;Biomedical Engineering;Blood Circulation Time;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;Cell Count;Cell Survival;Cell Therapy;Cells;Charge;clinical translation;Coculture Techniques;Computer Models;Coupled;cytotoxic;Cytotoxic T-Lymphocytes;Defect;Diameter;Disease;Dose;Electron Microscopy;Elements;Environment;Euthanasia;Exocytosis;Failure;Flow Cytometry;Fluorescence Microscopy;Foundations;Future;Generations;Glioblastoma;Glioma;Goals;Image;imaging approach;imaging modality;Imaging technology;immune imaging;Immunotherapy;Impact evaluation;improved;In Vitro;in vivo;insight;instrumentation;interest;Intracranial Neoplasms;Ionizing radiation;iron oxide nanoparticle;Label;Life;Longitudinal Studies;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Measures;Mediating;Melanoma;Methods;Modeling;Modification;Molecular;molecular imaging;Monitor;Motivation;mouse model;Multimodal Imaging;Mus;nanoparticle;neoplastic cell;nuclear imaging;Organ;Oxygen;particle;Penetration;Performance;Phenotype;Physics;Polymers;preclinical evaluation;Preclinical Testing;Property;public health relevance;Qualifying;Quantitative Evaluations;quantitative imaging;Research;research and development;Research Project Grants;Resolution;responders and non-responders;response;Route;Signal Transduction;Site;Solid;Solid Neoplasm;Specificity;Stratification;success;superparamagnetism;Surface;T cell therapy;T-Lymphocyte;Therapeutic;Tissues;tomography;tool;Toxic effect;Tracer;trafficking;treatment response;tumor;uptake;Validation;Work

PROJECT_TITLE: Nanoparticles to Track T Cell Immunotherapy Using Magnetic Particle Imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative  The proposed work will uncover intrinsic shape of DNA duplexes and elucidate its roles in CRSIPR Cas9 and Cas12a target discrimination. Information learned will be incorporated into algorithms for enhancing CRISPR targeting specificity, ultimately advancing CRISPR-based technologies for effective genome manipulation in both basic research and therapeutic development. 1

PI_NAMEs: QIN, PETER Z (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3-Dimensional;Affect;Algorithms;Base Pairing;Basic Science;Biology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Discrimination;Distal;DNA;DNA Sequence;DNA-Binding Proteins;ds-DNA;Engineering;Gene Targeting;Genes;Genome;genome editing;genome-wide;Guide RNA;improved;Learning;Methods;Molecular Conformation;next generation;Nucleic Acids;Peripheral;physical property;Proteins;research and development;RNA;Role;Shapes;Site;Specificity;Spin Labels;System;Technology;Therapeutic;therapeutic development;Work

PROJECT_TITLE: Elucidating the Role of DNA Shape in CRISPR Target Discrimination

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

PHR: PROJECT NARRATIVE The FDA has launched numerous initiatives to improve trial design and enrollment practices; however, there are significant gaps between the need to improve Alzheimer’s disease (AD) trial eligibility criteria design and ways available to fulfill the need in practice. We propose (1) novel causal-principled, explainable AI (XAI) approaches to generate real-world evidence using large collections of real-world data to facilitate AD trial eligibility criteria design, and (2) to create the web-based ALZHEIMER'S DISEASE ELIGIBILITY EXPLAINER (ADEP) tool. We will leverage two large RWD resources, the OneFlorida+ (~19 million patients from Florida, Georgia, and Alabama) and INSIGHT (~12 million New Yorkers) clinical research networks (CRNs) contributing to the national Patient- Centered Clinical Research Network (PCORnet).

PI_NAMEs: BIAN, JIANG ;WANG, FEI  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Adoption;Alabama;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Artificial Intelligence;Characteristics;Clinical;Clinical Research;Clinical Trials;cohort;Collection;computable phenotypes;Data;data resource;Data Science;design;Detection;Documentation;Effectiveness;electronic health record system;Eligibility Determination;Ensure;Event;explainable artificial intelligence;Florida;General Population;high dimensionality;improved;Individual;interest;Libraries;Machine Learning;Methodology;Methods;Modeling;Natural Language Processing;novel;Online Systems;Outcome;Participant;patient oriented;patient safety;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;privacy preservation;Process;prototype;Research;Research Personnel;Safety;Serious Adverse Event;Site;study population;success;Target Populations;tool;trait;Treatment Effectiveness;Treatment Efficacy;trial design;trial enrollment;user centered design;Work

PROJECT_TITLE: Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE We propose a large, multi-state epidemiological study to assess whether select social determinants of health – as reported on patient records through the use of ICD-10 Z-codes – modify associations between outdoor temperature and visits to hospital emergency departments. A better understanding of the social determinants of temperature vulnerability can help decision makers protect high-risk groups through targeted interventions.

PI_NAMEs: SCOVRONICK, NOAH C (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Accident and Emergency department;Affect;American;Area;Arizona;California;Categories;Cessation of life;Characteristics;Climate;climate change;climate impact;Clinical;Code;Community Surveys;Cross-Over Studies;Data;Data Set;deprivation;Diagnosis;disability-adjusted life years;Disparity population;Economics;Emergency department visit;Environment;Environmental Epidemiology;Environmental Exposure;epidemiology study;Ethnic Origin;Exposure to;extreme heat;Frequencies;Future;future climate scenario;Government;Health;health data;health disparity;Health Personnel;Heat Waves;high risk population;Homelessness;Hospitals;Household;Housing;Income;Individual;Infrastructure;Institution;International Classification of Diseases;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Investments;Knowledge;Link;Location;Low income;Methodology;Missouri;models and simulation;Modification;Morbidity - disease rate;Neighborhoods;New York;Oregon;Outcome;outreach program;Patients;Policies;Policy Maker;Population;population survey;Poverty;prevent;Public Health;Race;Records;Reporting;Research;Research Design;Resources;Risk;Risk Factors;social;social determinants;Social Environment;social health determinants;Social isolation;Standardization;State Hospitals;Stratification;Subgroup;System;Temperature;Unemployment;United States;US State;Visit;Weather

PROJECT_TITLE: Modification of temperature-morbidity associations by social determinants of health: the use of Z-coding

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Although many human cancers share similar metabolic alterations, including the Warburg effect, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. We found that phospholipase A2G7 (PLA2G7) is selectively important in Nras Q61K/R mutants in melanoma cells, which is a secreted enzyme that catalyzes the degradation of phospholipid platelet activating factor (PAF) and production of a biologically inactive phospholipid product Lyso-PAF to regulate PAF-induced inflammation. We hypothesize that “functionless” Lyso-PAF has an intracellular and signaling role that is selectively important for mutant Nras transformation by contributing to PAK2-dependent S338 phosphorylation of Raf-1, and thus PLA2G7 represents an alternative therapeutic target to selectively treat melanoma cells expressing mutant Nras.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acetates;Acetoacetates;Address;Attenuated;Binding;Biochemistry;Biological;Biological Process;BRAF gene;Bypass;cancer cell;casein kinase II;Cell Line;Cell Proliferation;Cells;Chondroitin;Chondroitin Sulfate A;Clustered Regularly Interspaced Short Palindromic Repeats;Data;design;Development;dietary supplements;Drug Screening;Enzymes;Exhibits;extracellular;Human;In Vitro;in vivo;Inflammation;inhibitor;ketogentic;Ketone Bodies;knock-down;Knock-out;Leukocytes;Libraries;Lyase;lyso-PAF;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;MAP2K1 gene;mast cell;Mediating;Melanoma;Melanoma Cell;Messenger RNA;Metabolic;Metabolism;Molecular;mutant;Mutation;Oncogenes;PAK2 kinase;Pathway interactions;patient derived xenograft model;Phospholipase;Phospholipid Degradation Pathway;Phospholipids;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Platelet Activating Factor;Platelet Activating Factor Degradation;Production;Proliferating;prostate cancer cell;Proto-Oncogene Proteins c-akt;PTEN gene;recruit;Research;Role;Screening Result;Series;Signal Transduction;small hairpin RNA;small molecule;Structure;Succimer;T-Lymphocyte;The Cancer Genome Atlas;therapeutic target;tumor;tumor growth;Vascular Permeabilities;Warburg Effect

PROJECT_TITLE: Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: NARRATIVE Interactions with complex objects such as carrying a cup filled with coffee are ubiquitous in daily life and essential for maintaining independence. Dexterous handling of objects is challenging as they create complex interaction forces that humans need to predict, preempt, and compensate for. Implementing the task of “carrying a cup of coffee” in virtual and real environments, we examine both healthy and neurologically impaired individuals to test the hypothesis that humans achieve dexterity by simplifying these interactions, i.e., by making them predictable.

PI_NAMEs: STERNAD, DAGMAR  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Basic Science;Behavior;Clinic;Clinical;clinical application;Coffee;cohort;Compensation;Complex;computational neuroscience;Custom;Device Designs;Devices;dexterity;Dimensions;dynamic system;Ensure;Environment;experience;experimental study;Failure;Feasibility Studies;Feedback;Female;Functional impairment;Funding;General Hospitals;Goals;Hand;haptics;high dimensionality;Human;Impairment;Individual;Information Theory;innovation;insight;internal control;Lead;Learning;Life;Manuals;Massachusetts;Measurement;medical schools;Methodology;Modeling;Modification;Motor;motor control;motor impairment;motor recovery;Movement;multidisciplinary;Nervous System Disorder;neural;Neurologic;Neurosciences;Noise;Nonlinear Dynamics;novel;novel strategies;object motion;Patients;Performance;Periodicity;portability;post stroke;preempt;prevent;Process;Property;Recovery;Research;Research Personnel;Risk;Robotics;scale up;sensorimotor system;Severities;simulation;Stroke;stroke patient;System;Testing;tool;Translating;Upper Extremity;virtual;virtual environment;virtual human

PROJECT_TITLE: Predictability in complex object control


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Limited mobility due to conditions like osteoarthritis, cerebral palsy, and Parkinson’s affects millions of individuals, at a great cost to public health and personal well-being. Rehabilitation can dramatically improve mobility and function, but current rehabilitation practice requires in- person guidance by a skilled clinician, increasing expense and limiting access. This project will revolutionize how we diagnose, monitor, and treat mobility limitations and enable personalized rehabilitation at low cost and on a massive scale using wearable sensing technology in the future.

PI_NAMEs: DELP, SCOTT L (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;Behavioral Model;Binding;biomechanical model;Biomechanics;Biomedical Engineering;biomedical informatics;Biomedical Technology;Cellular Phone;Cerebral Palsy;Characteristics;Clinic;Clinical;Communities;Computer software;coral;cost;Data;Data Science;Degenerative polyarthritis;Diagnosis;Disease;Documentation;Educational workshop;Engineering;evidence base;Exercise;experience;Exposure to;Feedback;Foundations;Freezing;functional improvement;Future;Gait;Goals;Guidelines;handheld mobile device;health goals;Home;Human;Image;improved;improved mobility;Individual;individualized medicine;industry partner;innovation;insight;joint loading;Joints;kinematics;large scale data;Leadership;Literature;Locomotion;machine learning model;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;mHealth;mobile computing;mobile sensing;mobile sensor;Modeling;Monitor;Motion;Movement;multidimensional data;Muscle;Obesity;open source;Parkinson Disease;Pathologic;Patients;Personal Satisfaction;Persons;programs;Public Health;Recommendation;Records;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;Resources;sensor technology;Series;Services;skills;smart watch;societal costs;Software Tools;symposium;terabyte;Time;tool;tool development;Training;wearable device;wearable sensor technology

PROJECT_TITLE: Mobilize Center: Models for Mobile Sensing and Precision Rehabilitation


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cerebral Palsy;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Algorithms;Area;Behavioral Model;Big Data to Knowledge;Binding;Biomechanics;biomedical data science;Biomedical Technology;Cellular Phone;Cerebral Palsy;Characteristics;Clinic;Clinical;Communication;Computer Models;Computer software;computerized tools;Consultations;cost;Data;Degenerative polyarthritis;Development;Diagnosis;Disease;Effectiveness;Elements;Exercise;experience;Face;functional improvement;Funding;Future;Gait;Geography;Goals;health goals;Image;improved;improved mobility;Individual;individualized medicine;innovation;insight;Institution;Joints;kinematics;Lead;Leadership;Locomotion;machine learning model;Magnetic Resonance Imaging;Measurement;Measures;meetings;Metabolic;Methodology;mobile sensing;mobile sensor;Modeling;Monitor;Motion;Movement;multidimensional data;Muscle;National Institute of Biomedical Imaging and Bioengineering;Obesity;Parkinson Disease;Patients;Persons;programs;Records;recruit;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Resources;Running;sensor technology;Series;Services;simulation;skills;societal costs;Structure;Technology;technology research and development;terabyte;Testing;Time;tool;Training;United States National Institutes of Health;Universities;usability;wearable sensor technology;Work

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Alcohol use disorder (AUD) is a crippling condition that impacts approximately 1 in 12 Americans, and exposure to stress has been demonstrated to both increase vulnerability to developing AUD as well as worsen AUD in those already suffering. Brain stress systems, such as the dynorphin/kappa opioid receptor (Dyn/KOR) system, have been implicated in neurological adaptations to stress and/or alcohol exposure which drive negative behavioral states. In this proposal, we examine how KORs adapt in various brain regions associated with alcohol and stress in response to chronic dependency-like alcohol exposure and a two stress paradigms in mice, in the hopes that our results will help guide pharmacological treatment of both AUD and negative affect conditions.

PI_NAMEs: HOLLERAN, KATHERINE MERCEDES;JONES, SARA RAULERSON (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abate;Abstinence;Acute;addiction;Affect;Affective Symptoms;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;Amygdaloid structure;Animals;Anxiety;anxiety reduction;anxiety-like behavior;anxiety-related behavior;Automobile Driving;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;cell type;Chronic;comorbidity;Compulsive Behavior;Consumption;Corpus striatum structure;Cues;Dependence;Disease;Dopamine;dopamine system;dopaminergic neuron;drinking;drug of abuse;Dynorphins;Ethanol;Evaluation;Exposure to;Female;Functional disorder;Goals;Heavy Drinking;Individual;kappa opioid receptors;knock-down;Ligands;male;Marble;Measures;Mediating;Mental Depression;Microdialysis;Modeling;Monkeys;Motivation;mouse model;Mus;negative affect;nerve supply;Neurobiology;Neurologic;Neuropeptides;novel;Nucleus Accumbens;Opioid Antagonist;optogenetics;Outcome;Pharmacological Treatment;Play;Post-Traumatic Stress Disorders;Procedures;Protocols documentation;Recording of previous events;Regulation;Relapse;response;Role;sensor;sex;sexual dimorphism;Signal Transduction;Stress;Swimming;Symptoms;System;targeted treatment;Therapeutic;Time;traumatic stress;United States;Ventral Tegmental Area;Viral;Withdrawal;Work

PROJECT_TITLE: Alcohol/Stress Effects on Kappa Opioid Receptors in the Amygdala and Accumbens


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: We have shown that grafts of human neural stem cells (NSCs) improve motor recovery after cervical contusive spinal cord injury (SCI) in a large animal model. The present work will increase understanding of mechanisms underlying graft-related improvements and will explore pharmacological and molecular methods of enhancing NSC-mediated regeneration and functional recovery after SCI in a large animal model.

PI_NAMEs: BEATTIE, MICHAEL S;BRESNAHAN, JACQUELINE C;ROSENZWEIG, EPHRON SOLOMON (contact);TUSZYNSKI, MARK H.

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 4-Aminopyridine;Agonist;Anatomy;Animal Model;Axon;axon regeneration;California;Cells;Cervical;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Contusions;Data;designer receptors exclusively activated by designer drugs;Doctor of Philosophy;Electrophysiology (science);embryonic stem cell;Exhibits;Foundations;functional improvement;functional outcomes;Future;Goals;Grant;Human;human embryonic stem cell;improved;In Vitro;Injections;knock-down;Knowledge;Lead;Leadership;Lesion;Literature;Macaca mulatta;Mediating;member;Methods;Molecular;Monkeys;Motor Cortex;motor recovery;Movement;Multiple Sclerosis;Mus;Natural regeneration;nerve stem cell;neural;neural circuit;neural implant;Neurons;nonhuman primate;Performance;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;Primates;PTEN gene;Rattus;Recovery;Recovery of Function;regenerative therapy;Research;Rodent;Role;Site;small hairpin RNA;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;stem cell fate;stem cell therapy;Stem cell transplant;Technology;Text;Translations;Transplantation;Work

PROJECT_TITLE: Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cerebral Palsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Osteoarthritis;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

PROJECT_TERMS: Acceleration;Address;adduct;Affect;Algorithms;Anthropometry;Behavioral Model;Binding;biomechanical model;biomechanical test;Biomechanics;Biomedical Research;Biomedical Technology;Cellular Phone;Cerebral Palsy;Characteristics;Clinic;Clinical;Communities;Complex;Computer software;cost;crouch gait;Data;data-driven model;Degenerative polyarthritis;design;Diagnosis;Disease;Energy consumption;Equipment;Exercise;experience;foot;Foundations;functional improvement;Future;Gait;Goals;health goals;Human;Image;improved;improved mobility;Individual;individualized medicine;innovation;insight;joint loading;Joints;kinematics;Kinetics;Knee;Leadership;Length;Locomotion;machine learning method;machine learning model;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;mobile sensing;mobile sensor;Modeling;Monitor;Motion;Movement;Movement Disorders;multidimensional data;Muscle;Muscle Fibers;muscular system;Musculoskeletal;neural;Obesity;open source;Operative Surgical Procedures;Optics;Osteoporosis;Parkinson Disease;Pathologic;Patients;Persons;pressure;Publications;Records;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;Resources;Risk;robot assistance;robot rehabilitation;sensor;sensor technology;Series;Services;Skeletal system;skills;societal costs;success;System;Tendon structure;terabyte;Time;tool;treatment planning;Upper Extremity;wearable device;wearable sensor technology;wireless;Work

PROJECT_TITLE: Measure: Biomechanics via Wearable Sensors


ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: The research will deliver a low-cost, fieldable, non-cryogenic multichannel system to enable interleaved measurements of magnetic resonance imaging (MRI) in the ultra-low field (ULF) regime (<< 1 T) and magneto- encephalography (MEG) of the human brain, substantially benefiting functional brain imaging with enhanced image quality and speed. The advanced biomedical technology will aid in diagnosis and treatment of multiple brain disorders with the potential to provide new insights into brain function. The hybrid MEG-MRI system could resolve lack of clinical MEG-MRI imaging services in suburban and regional locations, impacting public health care services in the USA as well as worldwide.

PI_NAMEs: KIM, YOUNG JIN  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Acceleration;Algorithms;Alkali Metals;Anatomy;Area;Biomedical Technology;Brain;Brain Diseases;Brain imaging;Brain Mapping;Cardiac;Cells;Chest;Childhood;Clinic;Clinical;cost;Coupled;Coupling;cryogenics;data acquisition;Dedications;design;Deterioration;Development;Devices;Diagnosis;Epilepsy;Fatigue;Fiber;field study;flexibility;Frequencies;Geometry;Head;health care service;Helmet;Hospitals;Human;human imaging;Hybrids;Image;Image Enhancement;imaging system;improved;insight;instrument;Laboratories;Lasers;Link;Location;magnetic devices;magnetic field;Magnetic Resonance Imaging;Magnetism;Magnetoencephalography;mathematical ability;Measurement;Metals;Methods;mobile application;Modality;neuroimaging;Neurologic;neurosurgery;novel;novel strategies;operation;Patients;Performance;Physiologic pulse;portability;Positioning Attribute;prevent;Production;prototype;Public Health;Research;Resolution;sensor;Services;Signal Transduction;Source;source localization;Speed;Structure;suburb;superconducting quantum interference device;System;Technology;Testing;Time;vapor;Water;wearable device;Work

PROJECT_TITLE: Non-cryogenic Fieldable Interleaved Magnetoencephalography and Magnetic Resonance Imaging based on Multichannel Atomic Magnetometers


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

PHR: PROJECT NARRATIVE The proposed research will determine the underlying mechanisms for ADAR1 sensitivity in triple-negative breast cancer. The ARF tumor suppressor directly binds to ADAR1, and ARF's loss in triple-negative breast cancer allows for ADAR1 to repress type I IFN signaling and inhibit immune cell infiltration. Accomplishing the aims in this proposal has critical implications for informing new approaches in treating triple-negative breast cancer through activation of IFN signaling in the tumor microenvironment.

PI_NAMEs: WEBER, JASON  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acceleration;ADAR1;Agonist;Alleles;anti-cancer research;anti-tumor immune response;Anti-viral Response;Binding;Binding Proteins;Biochemical;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;Breast Epithelial Cells;Cancer cell line;Cell Death;Cell Nucleolus;Cells;Cellular biology;Cessation of life;Chronic;Clinical;Complex;Data;Deaminase;Dependence;DNA;effective therapy;Environment;Enzymes;Epithelium;Etiology;functional loss;Gene Mutation;Gene Targeting;Genes;Genetic;genetic signature;Human;Immune;immune cell infiltrate;In Vitro;in vivo;innovation;insight;Interferon Activation;interferon alpha receptor;Interferon Type I;Interferons;knock-down;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;MDM2 gene;Molecular;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Oncogenic;Pathway interactions;patient response;Patient-derived xenograft models of breast cancer;Patients;Penetration;peptidomimetics;Phenotype;prevent;Production;programmed cell death ligand 1;protein expression;protein function;Proteins;Proto-Oncogenes;Publishing;Repression;Research;Research Personnel;Resistance;response;RNA;Role;Signal Transduction;stem;STING agonists;Stress;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Titrations;TP53 gene;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor Suppressor Proteins;Tumor-Infiltrating Lymphocytes;tumorigenesis;Work

PROJECT_TITLE: Antagonistic role of ARF and ADAR1 in triple-negative breast cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Liver Disease;Lupus

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Mendelian disorders associated with increased IFN levels have now been grouped as a distinct disease category. These patients develop debilitating and potentially fatal conditions where the pathogenesis is poorly understood and therapeutic options are limited. We have identified a murine model of DNaseII deficiency that recapitulates many of the clinical features of patients with DNaseII hypomorphic mutations, including liver fibrosis. This application will explore the interplay between nucleic acid sensors and elevated levels of type II and type III IFNs in the pathogenesis of DNaseII deficiency and related disorders that can lead to liver fibrosis. The mechanisms we are exploring are highly relevant to human disease and the key to future targeted therapies.

PI_NAMEs: MARSHAK-ROTHSTEIN, ANN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Antigen-Presenting Cells;Attention;Autoantibodies;Autoimmune Diseases;autoinflammation;autoinflammatory;autoinflammatory diseases;B-Lymphocytes;Brain;CASP8 gene;Categories;CCL8 gene;Cell Death;Cell Death Induction;Cell Lineage;Cells;Central Nervous System Diseases;Cessation of life;Chronic;Clinical;Cutaneous;cytokine;Data;Defect;Deoxyribonucleases;Dependence;Deposition;Dermal;Development;Disease;DNA;ds-DNA;Endosomes;Environment;Epithelial Cells;exhaustion;Exhibits;Extramedullary Hematopoiesis;Fibrosis;Flare;Flow Cytometry;Future;gain of function mutation;Gene Targeting;Goals;Hepatocyte;Heterogeneity;human disease;Immune;In Vitro;in vivo;Induction of Apoptosis;Infant;Infiltration;Inflammation;Inflammatory;insight;Interferon Type II;Interferons;keratinocyte;Knock-out;Knockout Mice;Ligands;Liver Fibrosis;loss of function;Lupus;lupus cutaneous;lupus-like;Macrophage;Memory;Mendelian disorder;Mitochondrial RNA;Modeling;Molecular Chaperones;mouse model;Mus;Mutation;Myelogenous;Myeloid Cell Activation;Myocarditis;neutrophil;novel;nuclease;Nucleic Acids;Organ;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patients;Pattern recognition receptor;Phenotype;Play;prevent;Production;Proteins;pseudotoxoplasmosis syndrome;Pulmonary Fibrosis;receptor;Recurrence;Regulation;Reproducibility;Ribosomal RNA;Role;sensor;Serum;Signal Transduction;Site;Skin;skin lesion;skin organogenesis;Sorting;System;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Th1 Cells;Therapeutic;therapeutic target;therapeutically effective;Tissues;TLR7 gene;trafficking;transcriptome sequencing;type I interferon receptor;Up-Regulation;UV Radiation Exposure;Work

PROJECT_TITLE: The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The spread of infections in hospitals represents a major risk to patients seeking care in healthcare facilities. In this proposal we seek to develop, validate and apply strategies grounded in genomics to more effectively track the spread of infections and thereby enable the development of better infection prevention strategies.

PI_NAMEs: SNITKIN, EVAN  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Alleles;Antibiotic Resistance;Antibiotics;Automobile Driving;care seeking;Characteristics;Clinical Data;clinically relevant;cohort;Collaborations;Community Healthcare;community setting;comorbidity;connected care;Data;Detection;detection method;Development;Devices;Disease Outbreaks;Electronic Health Record;Environmental Pollution;Epidemic;epidemiologic data;Epidemiology;Error Sources;Evolution;experience;Generations;Genetic;genetic linkage;genome sequencing;genomic data;genomic epidemiology;Genomics;Grouping;Health care facility;health care settings;Health Personnel;Healthcare;High Prevalence;Hospitalization;Hospitals;Host resistance;improved;in silico;Infection;Infection prevention;Infrastructure;innovation;Interruption;Life;Link;Location;Low Prevalence;Manuals;Mediating;Methods;microbial;multi-drug resistant pathogen;Mutation;novel;Organism;Organism Strains;pathogen;Pathway interactions;Patient Isolation;Patients;Play;Population;Population Analysis;prevent;Prevention strategy;Productivity;Public Health;Rectum;Research Personnel;Resistance;Resolution;Risk;Role;sample collection;Sampling;Single Nucleotide Polymorphism;Source;Speed;stem;Time;tool;transmission process;Validation;Variant;Vulnerable Populations;whole genome

PROJECT_TITLE: Genomic methods for studying microbial transmission in healthcare settings

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: With the rise in opioid use disorder (OUD) and overdose, racialized disparities in buprenorphine access and use are a significant concern nationally—studies estimate that Black patients with OUD are 50-60% less likely to access buprenorphine compared to White patients, and similar disparities have also been observed for Hispanic/Latinx patients. COVID-19-related policy changes increased flexibility in the provision of buprenorphine and other effective medications for OUD over telehealth and present an unprecedented opportunity to examine impacts of a structural intervention—relaxed MOUD restrictions—on disparities that result from structural racism and discrimination (SRD). The proposed study, guided by Public Health Critical Race Praxis, will use data from the nation's largest provider of substance use care and quantitative and qualitative methods to examine the impact of these policy changes on racialized disparities for Black and Hispanic/Latinx patients to inform future policy and interventions to improve equitable care for OUD.

PI_NAMEs: CHEN, JESSICA ANN;WILLIAMS, EMILY CATERINA (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: access disparities;Address;Agonist;black patient;Black race;Buprenorphine;buprenorphine treatment;Caring;Chronic;clinical practice;cohort;Communities;community-level factor;coronavirus pandemic;COVID-19;COVID-19 impact;Critical Race Theory;Data;design;Diagnosis;Discrimination;Disparity;disparity reduction;Dose;Electronic Health Record;equilibration disorder;Equity;ethnic disparity;ethnic health disparity;Event;experience;federal policy;flexibility;Future;Gender;Guidelines;health care availability;health care disparity;Health system;Healthcare Systems;Hispanic;Home;Imprisonment;improved;Inequity;Integrated Health Care Systems;Interruption;Intervention;Interview;Latinx;Legal;lens;Life;Lived experience;medication for opioid use disorder;Methadone;Methods;Minority Groups;Naltrexone;National Institute of Drug Abuse;Not Hispanic or Latino;novel coronavirus;observational cohort study;Opioid;Opioid agonist;opioid epidemic;opioid overdose;opioid use disorder;Outcome;outcome disparities;Overdose;Overdose reduction;overdose risk;Pain management;Patients;Pattern;Perception;Persons;Pharmaceutical Preparations;Police;Policies;post-COVID-19;Provider;Public Health;Qualitative Methods;Race;racial disparity;racial population;Regulation;Relaxation;Research;Research Design;residential segregation;resilience;Resources;response;Sampling;Series;Shapes;stem;Stigmatization;Structural Racism;Structure;substance use;System;Technology;telehealth;Telemedicine;Telephone;therapy development;Time;Veterans Health Administration;Violence

PROJECT_TITLE: Applying Critical Race Theory to investigate the impact of COVID-19-related policy changes on racial/ethnic disparities in medication treatment for opioid use disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity;Physical Rehabilitation;Rehabilitation

PI_NAMEs: RE, CHRISTOPHER  (contact)

PROJECT_TERMS: Academia;Accelerometer;Address;Affect;Algorithms;automated segmentation;Behavioral Model;Binding;Biomechanics;Biomedical Research;biomedical scientist;Biomedical Technology;Cartilage;Cellular Phone;Cerebral Palsy;Characteristics;Classification;Clinic;Clinical;clinical practice;Complex;Computer software;coral;cost;Data;Data Set;deep learning;Degenerative polyarthritis;Democracy;design;Devices;Diagnosis;Disease;Elements;evidence based guidelines;Exercise;experience;Explosion;Familiarity;Foundations;Freezing;functional improvement;Future;Gait;gene interaction;Goals;health goals;heterogenous data;Image;imaging Segmentation;improved;improved mobility;Individual;individualized medicine;Industry;innovation;insight;instrument;Joints;kinematics;Knee;Knowledge;Label;Language;large datasets;Leadership;Locomotion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Manuals;Measurement;Measures;Metabolic;Methods;mobile sensing;mobile sensor;model building;Modeling;Modernization;Monitor;Motion;Movement;multidimensional data;multimodality;Muscle;neural;Obesity;open source;Parkinson Disease;Pathologic;Pathology;Patients;Persons;Physical activity;Population;Process;Pythons;Records;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;Resources;Roentgen Rays;scripting interface;sensor technology;Series;Services;skills;societal costs;success;Technology;terabyte;Text;Time;time use;tool;Training;training data;treatment planning;usability;wearable sensor technology;Work

PROJECT_TITLE: Analyze: Machine Learning for Mobility Data


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The discovery and characterization of novel immunotherapy targets is required to improve upon the response rates and overall survival of patients. A novel regulator of T cell activity, TrIP, has been shown to improve anti- tumor immunity in mice, but the mechanisms of these effects are poorly understood. This proposal seeks to explore in more detail the effects of TrIP modulation on individual T cell subsets using tumor models to better evaluate its potential as an immunotherapy target.

PI_NAMEs: MURTER, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Antigens;Antitumor Response;Binding;Biological;Biological Response Modifiers;Biology;cancer immunotherapy;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell membrane;Cell Proliferation;Cell Surface Proteins;cell type;Cells;Cellular Immunity;Complex;cytokine;Data;Down-Regulation;effector T cell;Exhibits;experimental study;extracellular;Frequencies;Future;Gene Expression;Genes;Growth;Growth Factor;Harvest;Homing;Immune;Immune response;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Integral Membrane Protein;Knock-out;Knockout Mice;Kringles;Lead;Ligation;Listeria;lymph nodes;Lymphoid;Malignant Neoplasms;Mediating;Membrane;Membrane Potentials;Metabolic;metabolic profile;Metabolism;Modeling;Mus;Mutation;Names;novel;Pathway interactions;Patients;Pattern;Phase;Phenotype;Phosphatidylinositols;Phosphotransferases;Play;Population;Positioning Attribute;Production;Proliferating;Protein Kinase Interaction;PTEN gene;receptor;recruit;Regulation;Reporting;Resistance;response;Rest;Role;Signal Pathway;Signal Transduction;src Homology Region 2 Domain;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;tool;trafficking;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Elucidating The Roles of PIK3IP1/TrIP Regulation on Distinct T Cell Subsets in the Context of Cancer


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: It is now established that single nucleotide polymorphisms that are associated with disease predominantly map to regulatory regions. We suggest that a vast majority of these will affect the timing by which paired regulatory elements find each other in order to activate gene expression. These are very early studies but we expect that insights from these experiments will provide new insights and future directions relating to the role of space and time in gene regulation/somatic recombination and how this relates to health and the development of disease.

PI_NAMEs: MURRE, CORNELIS  (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Address;Adopted;Affect;Amino Acids;Antibodies;Antigen Receptors;Architecture;B-Cell Development;B-Lymphocytes;Back;bcr-abl Fusion Proteins;Binding;Binding Proteins;Binding Sites;Cell Line;Cells;Chromatin;Chromatin Structure;Code;Color;crosslink;Crowding;Data;Development;Diffusion;Disease;Distal;DNA;Elements;Enhancers;Environment;EP300 gene;Epigenetic Process;experimental study;Frequencies;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Recombination;Genetic Transcription;Genome;Genomic Segment;Genomics;Grant;Health;Heavy-Chain Immunoglobulins;Histone Acetylation;Histones;IGH@ gene cluster;Image;insight;Label;Location;Maps;Measures;Monitor;Motion;mutant;novel strategies;Nuclear;Nuclear Lamina;Nucleic Acid Regulatory Sequences;Pattern;Phase;Positioning Attribute;promoter;Proteins;Receptor Gene;recruit;Regulatory Element;Role;Single Nucleotide Polymorphism;Site;Specificity;Speed;stem cells;TCF3 gene;Tetanus Helper Peptide;three dimensional structure;Time;transcription factor;Transferase;V(D)J Recombination;Virus;Visualization

PROJECT_TITLE: The 3D-Structures of the Immunoglobulin Heavy Chain Locus

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Clinical Research;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Chronic kidney disease is a common problem in the general community and the early changes in the kidney tissue that predict which people will develop chronic kidney disease are not well understood. This study will study the structures and proteins in kidney tissue specimens of patient populations that undergo removal of one kidney by surgery and have a relatively normal remaining kidney. The goal is to develop artificial intelligence-based image processing tools and protein marker tests that can identify kidney tissue with high risk features for the subsequent development of chronic kidney disease.

PI_NAMEs: RULE, ANDREW DAVID (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Age;Aging;Albuminuria;Anatomy;Area;Arteries;Arteriosclerosis;Artificial Intelligence;Atrophic;Biopsy;Biopsy Specimen;Blood capillaries;Blood Pressure;Blood Vessels;Bowman's space;capsule;Cell Density;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;clinically relevant;Communities;comorbidity;Core Biopsy;Data;Data Set;deep learning;density;Detection;Development;Diameter;differential expression;Discipline;Disease;Disease Outcome;Distal;Epithelial Cells;Excision;Fibrosis;follow-up;Functional disorder;Glass;glomerulosclerosis;Goals;graft failure;Health;high risk;Hypertension;image processing;Immunohistochemistry;interstitial;Intervention;Kidney;kidney biopsy;kidney cortex;Kidney Diseases;kidney imaging;kidney surgery;laser capture microdissection;learning network;Link;living kidney donor;Magnetic Resonance Imaging;Manuals;Mass Spectrum Analysis;Measures;Modeling;morphometry;Nephrectomy;Nephrons;Nephrosclerosis;novel;Obesity;Outcome;Parietal;Pathogenicity;Pathologic Processes;patient population;Patients;Persons;podocyte;Population;Populations at Risk;prognostic;protein biomarkers;Proteins;Proteinuria;Proteomics;Renal function;Reproducibility;research clinical testing;Resources;Risk Factors;Scanning;Site;Slide;Specimen;Stenosis;Structure;Technology;Testing;Tissues;tool;Tubular formation;tumor;Validation;whole slide imaging

PROJECT_TITLE: Automated detection of microstructural features that have unique protein markers and are prognostic for chronic kidney disease

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE The proposed research is relevant to public health because the ovarian reserve defines female reproductive lifespan, which in humans spans decades due to robust maintenance of meiotic arrest in oocytes residing in primordial follicles. This study will identify epigenetic states and their regulatory mechanisms that maintain the ovarian reserve in women and thereby impact the diagnosis of human female infertility and ovarian aging.

PI_NAMEs: NAMEKAWA, SATOSHI  (contact);SCHULTZ, RICHARD MORRIS

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adolescent;Adult;Age;age effect;Age Months;aged;CHD4 gene;Chromatin;Chromatin Structure;Complement;Complex;Couples;Data;data resource;Data Set;Deacetylase;design;Deterioration;Diagnosis;DNA Methylation;Embryo;Enhancers;Epigenetic Process;epigenome;epigenomics;exhaustion;Female;Female infertility;Fertility;Foundations;Functional disorder;Gene Expression;gene regulatory network;Gene Silencing;Germ Lines;Goals;Growth;histone modification;Human;human female;human old age (65+);insight;Investigation;Life;life span;Maintenance;Mediating;Meiosis;Meiotic Prophase I;member;Menopause;middle age;Molecular;Molecular Analysis;Mus;Nucleosomes;old mice;Oocytes;Oogenesis;Ovarian;Ovarian aging;ovarian reserve;Ovary;Perinatal;Phase;Polycomb;postnatal;PRC1 Protein;Premature Ovarian Failure;Primordial Follicle;Process;programs;promoter;Protocols documentation;Puberty;Public Health;reproductive;reproductive senescence;Research;Role;single-cell RNA sequencing;sound;Testing;Woman

PROJECT_TITLE: Ovarian reserve formation and maintenance

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]