NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: TULSA

ORG_DEPT: PSYCHIATRY

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

ORG_STATE: OK

PHR: Project Narrative A critical need exists to increase the number of American Indian physician-scientists. To address this need, our program aims to establish a short-term summer research program for American Indian medical students to work jointly with mentors at 10 National Institute on Alcohol Abuse and Alcoholism-funded alcohol research centers and Oklahoma State University Center for Health Sciences to conduct studies focused on making alcohol research more rigorous and reproducible.

PI_NAMEs: VASSAR, MATT  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Advisory Committees;alcohol research;American Indians;Behavioral Sciences;career;case-based;Cherokee Nation;Department chair;Doctor of Philosophy;Event;experience;Funding;Grant;Health Sciences;Institution;Lead;Learning;Longitudinal Surveys;Manuscripts;medical schools;Medical Students;meetings;Mentors;Mentorship;Monitor;National Institute on Alcohol Abuse and Alcoholism;Oklahoma;outreach;Peer Review;Physicians;programs;Psychiatry;Publications;Records;Reproducibility;Research;responsible research conduct;Scientist;Students;success;summer research;summer student;Technology;Tribes;United States;Universities;Videoconferencing;Work

PROJECT_TITLE: A short-term summer research program for American Indian medical students


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Alport syndrome, a hereditary disease leading to kidney failure, has been known for 30 years to be caused by mutations in the glomerular basement membrane type IV collagen COL4A3, COL4A4, and COL4A5 genes. Although many treatments for the disease have been investigated, none have focused on attempting to fix the defective glomerular basement membrane, either by restoring the missing collagen IV chains or removing the Alport GBM’s ectopic noncollagenous components that help drive the disease. Here we will use new drugs, in vivo gene editing approaches, and recombinant collagens to attempt to normalize the glomerular filtration barrier in a mouse model of Alport syndrome.

PI_NAMEs: MINER, JEFFREY H (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Affect;Agrin;Aminoglycosides;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Animals;Attenuated;autosome;Basement membrane;Biomedical Research;Canis familiaris;Cells;Childhood;Clinical;Clinical Trials;Cochlea;COL4A3 gene;Collagen;Collagen Type IV;CRISPR/Cas technology;Cultured Cells;Data;Defect;design;Dialysis procedure;Disease;Disease Progression;Drug Combinations;Ear;End stage renal failure;Endothelial Cells;Engineering;Excision;expectation;experimental study;Exposure to;Extracellular Matrix;Eye;Failure;Fibrosis;Filtration;Foot Process;Gene Mutation;gene repair;gene-editing approach;Genes;Genetic;Genetic Diseases;genome editing;glomerular basement membrane;glomerular endothelium;glomerular filtration;glomerular function;glomerulosclerosis;Goals;Health;Hearing;Hearing problem;Heparan Sulfate Proteoglycan;Hereditary Disease;Hereditary nephritis;homologous recombination;Human;improved;in vivo;Inherited;Injury;innovation;interest;Intravenous;Investigation;Kidney;Kidney Diseases;Kidney Failure;Laminin;Lead;lens;Link;Liver;Mediating;Membrane Structure and Function;mouse model;mRNA Translation;Mus;mutant;Mutant Strains Mice;Mutation;Mutation Analysis;new technology;new therapeutic target;Newborn Infant;Nidogen;Nonsense Codon;Nonsense Mutation;novel strategies;novel therapeutic intervention;novel therapeutics;nuclease;Organism;Pathogenicity;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Plasma Proteins;podocyte;postnatal period;Predisposition;premature;Prevalence;Process;Protein Biochemistry;Protein Isoforms;Proteins;Publishing;Quality of life;Recombinants;Renal glomerular disease;Renin-Angiotensin System;repaired;Reporting;Research;Retina;Ribosomes;Secondary to;side effect;small molecule;standard of care;stem cells;Structure;success;Syndrome;System;Technology;Terminator Codon;Testing;therapeutic evaluation;Time;Transplantation;Tubular formation

PROJECT_TITLE: Innovative Approaches to Treating Alport Syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Mental Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Traumatic stress is a well-documented risk factor for mental illness, including Posttraumatic Stress Disorder, depression, and anxiety, which are prevalent and costly to the person and society. This program integrates the latest findings and concepts in a) epidemiologic risk and resilience and b) treatment development, evaluation and dissemination and implementation science to provide core training in these areas and ensure we have a research workforce that stands ready to make transformative advances in public health for those who have experienced traumatic events.

PI_NAMEs: DANIELSON, CARLA KMETT (contact);KILPATRICK, DEAN GAINES

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Basic Science;life span;Research Training;Translational Research;traumatic stress

PROJECT_TITLE: Basic & Translational Research Training in Traumatic Stress Across the Lifespan


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The Pharmacological Sciences Training Program (PSTP) at Georgetown University Medical Center is an interdisciplinary training program for a diverse community of doctoral candidates across Ph.D. disciplines who are dedicated to thesis research in pharmacological science; we provide Ph.D. students with advanced training in physiology and pharmacotherapeutics, with a view ranging from cellular signaling networks to organ function to behavior and systems medicine. Faculty mentors in the PSTP share a common research interest in identifying drug targets within cellular signaling pathways to treat human disease. Trainees will prepare for future careers in academia, pharma or biotechnology industry, or drug regulatory agencies through dissertation research and through internship experiences.

PI_NAMEs: FORCELLI, PATRICK ALEXANDER (contact);WELLSTEIN, ANTON

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: pharmacologic;Science;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: This research will provide basic insight into how genes control tooth formation and tooth replacement. This knowledge will help efforts to engineer tooth formation in vitro and ultimately regenerate teeth in vivo, as well as provide fundamental knowledge of vertebrate organ regeneration.

PI_NAMEs: MILLER, CRAIG THOMAS (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Adult;Affect;Alleles;appendage;Biological Assay;Biological Models;Biology;BMP6 gene;Candidate Disease Gene;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Data;deciduous tooth;Dental;Dentistry;Dentition;Development;Developmental Biology;developmental genetics;Dyes;Engineering;Enhancers;Epithelium;experimental study;Fishes;Fresh Water;Gasterosteidae;Gene Expression;Genes;Genetic;genetic analysis;Genetic study;genome editing;Genomic Segment;Genomics;Goals;Hair;hair regeneration;Heritability;Human;human old age (65+);In Vitro;in vitro regeneration;in vivo;Individual;insight;Jaw;Knowledge;Label;Learning;Life;Ligands;loss of function;Maps;marine;Mesenchymal;Mesenchyme;Molecular;Mus;mutant;Mutation;Natural regeneration;offspring;Oral;Organ;organ regeneration;Organogenesis;Outcome;Pathway interactions;Pattern;Persons;Pharyngeal structure;Phenotype;Physiologic pulse;Population;Positioning Attribute;public health relevance;regenerative;Research;Signal Pathway;Signal Transduction;Skin;System;Testing;Tooth regeneration;Tooth structure;Transgenic Organisms;Variant;Vertebrates;WNT Signaling Pathway;Work

PROJECT_TITLE: Development Genetics of Tooth Number Variation in Sticklebacks

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narative Hair cells in the inner ear mediate our sense of hearing and balance. Hair cells are exposed to continuous mechanical stress, causing damage and cell death over time. Because mammalian auditory hair cells do not regenerate, the repair of hair cell damage is important for continued auditory function throughout life. In this proposal, we plan to study the molecular processes involved in the repair of the stereocilia actin core. Stereocilia damage, and mechanisms that mediate their repair, are expected to be key for understanding and alleviating progressive hearing loss in humans.

PI_NAMEs: SHIN, JUNG-BUM  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Actin-Binding Protein;Actins;Age;Aging;alpha catenin;Auditory;beta Actin;Binding;Binding Proteins;Binding Sites;C-terminal;Cardiac Myocytes;Cell Death;cell injury;Cell Line;Cell Maintenance;Cells;Characteristics;cofilin;Complex;cysteine rich protein;Data;depolymerization;Equilibrium;Exhibits;experience;experimental study;Exposure to;F-Actin;Fiber;Fibroblasts;gamma Actin;Genetic;genome wide association study;Hair;Hair Cells;Hearing;hearing impairment;Human;in vivo;Inner Hair Cells;Intercalated disc;interest;Knock-in Mouse;Knockout Mice;Label;Labyrinth;Lasers;Lesion;Life;LIM Domain;LIM Domain Protein;live cell imaging;loss of function;Loudness;Maintenance;Mechanical Stress;Mechanics;Mediating;Metabolic stress;Microfilaments;Modeling;Molecular;mouse model;Mus;muscle LIM protein;Mutation;Noise;noise exposure;Noise-Induced Hearing Loss;novel;ototoxicity;paralogous gene;Pharmaceutical Preparations;Play;prevent;Prevention;Process;programs;progressive hearing loss;Property;Protein Isoforms;Proteins;Proteomics;recruit;repair function;repaired;Reporting;Research;response;RNA Splicing;Role;Sensory Hair;Site;Stress Fibers;Stretching;Testing;Thymus Gland;Time;Torsion;transcriptome sequencing;Vinculin;virtual

PROJECT_TITLE: Mechanosensor Proteins in Hair Cell Repair

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Our proposal, involving 3 collaborating academic Neonatal Intensive Care Units, is to determine predictive models of therapeutic hypothermia (TH) efficacy in hypoxic ischemic encephalopathy (HIE). Using a holistic and integrative approach, including deep clinical and community-based data, and molecular biomarkers of multiple biologic pathways, analyzed within a fully connected parsimonious neural network will best describe relationships with longitudinal outcomes and be able to predict response to TH in individual patients. Completion of our aims will identify and then validate the clinical, socioeconomic, and molecular mechanisms driving clinical heterogeneity in HIE and response to TH and allow rapid deployment of a dynamic, precision-based model to optimize patient selection for future HIE adjunctive therapies.

PI_NAMEs: EVERETT, ALLEN D;NORTHINGTON, FRANCES J (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: 2 year old;Adult;Age;Alabama;Automobile Driving;Biological;Biological Markers;Brain Injuries;brain magnetic resonance imaging;Caring;Cessation of life;Child;Clinical;clinical biomarkers;Clinical Data;clinical heterogeneity;cohort;Collaborations;Communities;Computer Simulation;cost;Coupled;Data;Data Scientist;Data Set;Data Sources;data-driven model;Dimensions;disability;Effectiveness;Enrollment;exosome;experience;feeding;follow-up;Funding;Future;Health system;improved;improved outcome;in silico;Individual;individual patient;Intervention;Intervention Trial;Investigation;Knowledge;Life;Machine Learning;machine learning method;Magnetic Resonance Imaging;Manuscripts;Measures;Methods;Modeling;modifiable risk;Molecular;molecular marker;Molecular Profiling;National Institute of Child Health and Human Development;natural hypothermia;Neonatal;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonate;network models;neural network;neurodevelopment;novel;novel marker;Nucleic Acids;Outcome;participant enrollment;Pathway interactions;patient safety;Patient Selection;Patient-Focused Outcomes;Patients;Peer Review;phenotypic biomarker;phenotypic data;predicting response;predictive modeling;prevent;Probability;prospective;Proteins;Publishing;Research Personnel;response;Retinoscopy;Right to Treatments;Risk Factors;Severities;socioeconomics;Stratification;Testing;Therapeutic;Time;Universities;Validation;Virginia

PROJECT_TITLE: Advanced therapeutic hypothermia efficacy network modeling in neonatal HIE


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Neurosciences

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Public Health Relevance Statement: Chronic itch associated with inflammatory skin diseases such as atopic dermatitis, can become both physiologically and psychologically debilitating and impart serious clinical consequences. We will study how an endogenous ligand that releases in the skin and then sets in motion the following itch circuit by binding to integrin receptor expressed in the dorsal root ganglia neurons, called TRPV1 neurons, as a result, to propagate the sensation of chronic itch by releasing neuropeptide NPPB in the spinal cord. Our proposed research will identify a molecular pathway involved in cutaneous-nerve responses in the dissemination of chronic itch and may provide potentially open new therapeutic targets for prospective treatment for chronic itch associated with atopic dermatitis.

PI_NAMEs: MISHRA, SANTOSH K. (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Adolescent;Adrenal Cortex Hormones;Affect;Afferent Neurons;Allergens;Atopic Dermatitis;autocrine;Binding;Brain;Calcipotriene;calcium indicator;cell type;Cells;Cellular biology;Child;Chronic;chronic itch;Clinical;Complex;Cutaneous;cytokine;effective therapy;Esthesia;Generations;Genetic;IL7R gene;Image;Immune response;in vivo;Infectious Skin Diseases;Inflammatory;Integrin alphaVbeta3;Integrin Binding;Integrins;keratinocyte;Knock-out;Ligands;Link;Liquid substance;Molecular;Motion;mouse model;Mus;Nerve;Neural Pathways;Neurologic;Neuromodulator;Neurons;Neuropeptides;new therapeutic target;novel;paracrine;Pathway interactions;Patients;periostin;Peripheral;Pharmacology;Physiological;polypeptide;Population;Predisposition;Production;prospective;Proteins;Pruritus;psychologic;public health relevance;receptor;Receptor Signaling;Research;response;Role;saluretic;Secondary to;Signal Pathway;Signal Transduction;Skin;skin disorder;Spinal Cord;Spinal Ganglia;Stimulus;subcutaneous;Testing;Topical application;transmission process;TRPV1 gene;TSLP gene;Up-Regulation;Viral;Wild Type Mouse

PROJECT_TITLE: Integrin receptor: A connecting link between skin and peripheral sensing neurons in atopic dermatitis

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The proposed project will help address structural racism and discrimination, and its manifestations and impact on minoritized individuals and groups in the biomedical workforce by developing and utilizing a series of 16 training modules designed specifically for biomedical trainees, supervisors/faculty, and 4 briefer modules for institutional leaders. Using evidence-based methods, the training modules will be iteratively designed to be feasible, engaging, and efficient, as well as self-directed, self-paced, publicly accessible, and user-friendly in the context of one's workday. If successful the modules will provide participants with knowledge of and skills for dismantling the impacts of structural racism and discrimination on minoritized trainees' career development and enhance diversity, equity, and inclusion in the biomedical training environment, which aligns directly with the mission of the NIGMS' Division of Training, Workforce Development, and Diversity and NIH's UNITE initiative.

PI_NAMEs: DUNCAN, ANDREA FREEMAN;LEFF, STEPHEN S (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;animation;anti-racism;Awareness;Behavior;Belief;Biomedical Research;career;career development;combat;community based participatory research;Data;Decision Making;design;Disability status;disadvantaged background;Discrimination;Education;Educational Curriculum;Educational process of instructing;effectiveness measure;Employment;Ensure;Environment;Equilibrium;equity, diversity, and inclusion;ethnic minority population;Ethnic Origin;Evaluation;evidence base;Faculty;Feedback;Force of Gravity;Fostering;Gender;Goals;Health;Healthcare;Hospitals;Hour;Impairment;Individual;Inequity;innovation;Institution;Institutional Policy;Intervention;iterative design;Knowledge;Language;Leadership;Learning;Learning Module;Lived experience;Mediating;Methods;microaggression;Minority;minority communities;Minority Groups;minority trainee;Mission;Modeling;National Institute of General Medical Sciences;Outcome;Participant;Patient Care;pediatric department;Pediatric Hospitals;perpetrators;Personal Satisfaction;Philadelphia;Physicians;pilot test;Policies;Positioning Attribute;Prejudice;Procedures;Process;Productivity;Program Effectiveness;programs;Psychologist;Race;racial discrimination;racism;Randomized;Recording of previous events;recruit;Research;Science;Self Direction;Self Efficacy;Series;Sex Orientation;Shapes;skills;Societies;Structural Racism;System;Trainers Training;Training;Training Activity;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;user-friendly;violence prevention;vocalization;Voice;Workforce Development

PROJECT_TITLE: Developing Modules to Address Microaggressions and Discriminatory Behaviors


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Stem cells are natural units of tissue repair and homeostasis, and their versatility holds promise for tissueregeneration. This research focuses on deciphering how progenitors within a single layer of developing skinsense local signals, remodel their cellular connections between themselves, their underlying basement membrane, and their surrounding niche cells to form a stratified, differentiating epidermis that maintains a balance between growth and differentiation. Our study is a fundamental prerequisite to understanding how these basic properties go awry in skin cancers, including squamous cell carcinomas.

PI_NAMEs: FUCHS, ELAINE  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Adhesions;Adult;Age;Algorithms;appendage;Architecture;Basement membrane;Basic Science;Behavior;Benign;Biology;Body Fluids;cancer risk;Cell Adhesion;cell behavior;Cell Differentiation process;cell growth;Cells;Chromatin;Clinical Trials;Clone Cells;Communication;Communities;Complex;Computer Simulation;Data;Dermal;Development;Differentiation and Growth;Disease;Embryo;epidermal stem cell;Epidermis;epithelial stem cell;Equilibrium;Event;Extracellular Matrix;Feedback;Fibroblasts;fitness;Functional disorder;Funding;Gene Expression;Genetic;Genetic Transcription;Growth Factor;Hair follicle structure;Homeostasis;Human;Immune;In Situ;in vivo;Inflammatory;inhibitor;insight;Intercellular Junctions;Knowledge;Lead;Learning;Ligands;Malignant Neoplasms;Maps;mechanical force;mechanical properties;Mediating;membrane synthesis;Methodology;Microbe;Molecular;Molecular Analysis;Monitor;Morphogenesis;Morphology;mouse model;mutant;Mutation;Natural regeneration;Nature;new technology;novel;Oncogenic;Papilloma;Pathway interactions;Pattern;Phenotype;Physiologic pulse;Predisposition;progenitor;Proliferating;Property;protein expression;Proteins;receptor;Regenerative Medicine;Rejuvenation;Research;Resolution;Resources;self-renewal;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin barrier;Skin Cancer;Skin Malignancy;skin organogenesis;Skin repair;spatiotemporal;Squamous cell carcinoma;stem cell niche;stem cell population;stem cells;Stratified Epithelium;Surface;Suspensions;Syndrome;System;Therapeutic;Therapeutic Intervention;Time;Tissue Preservation;tissue repair;Tissue Sample;tissue stem cells;Tissues;tool;transcriptome;Transducers;Undifferentiated;WNT Signaling Pathway;Work

PROJECT_TITLE: Cell adhesion and tissue dynamics in the skin

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Diabetes;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Group B Streptococcus (GBS) is a leading cause of stillbirth and neonatal death and pregnancies complicated by gestational diabetes mellitus are at increased risk for GBS infection and adverse outcomes. This proposal examines how GBS virulence and maternal immunity are altered in gestational diabetic pregnancies compared to healthy pregnancies. These studies seek to reveal novel host and bacterial markers that can be therapeutically targeted to prevent GBS colonization and disease in pregnant women and their newborns.

PI_NAMEs: PATRAS, KATY  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: adverse birth outcomes;adverse outcome;amniotic cavity;Amniotic Fluid;Animal Model;Antibiotic Prophylaxis;Antibiotics;Antimicrobial Resistance;Automobile Driving;Biological;Cells;Cessation of life;Clinical;Clinical Data;Clinical Research;collaborative environment;college;comparative;Complex;Control Groups;cytokine;design;diabetes control;diabetic;Diabetic mouse;Diet;Disease;Elderly;Employment;Environment;Exposure to;female reproductive tract;fetal;Fetal Tissues;Fetus;fitness;Gene Expression;Genes;Genetic;Genetic Transcription;Gestational Diabetes;Glucose;Group B Streptococcus colonization;healthy pregnancy;Hemolysin;Host Defense;Human;Hyperglycemia;Immune;Immune response;Impairment;In Vitro;in vitro activity;in vivo;Incidence;Individual;Infant;Infant Mortality;Infection;Inflammatory;innovation;insight;Insulin Resistance;Integration Host Factors;Invaded;Macrophage;maternal risk;Maternally-Acquired Immunity;Measures;Medical center;Medicine;Membrane;Metabolic;Metabolic Diseases;microbial;microbiota;Modeling;Mothers;mouse model;Mus;Neonatal;neonatal morbidity;Neonatal Mortality;neonatal period;neutrophil;Newborn Infant;non-diabetic;novel;novel therapeutic intervention;novel therapeutics;Onset of illness;Outcome;overexpression;pathogen;Pathogenesis;Pathway interactions;permissiveness;Physiology;Placenta;Population;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prevent;Prevention;Process;Production;Prognostic Marker;pup;recruit;Regulation;reproductive tract;Research;resistance gene;response;Risk;Risk Factors;Sampling;standard of care;stillbirth;streptococcal group B hemolysin;Streptococcal Infections;Streptococcus;Streptococcus Group B;Support Groups;Testing;Texas;Therapeutic;therapeutic target;Time;Tissues;tool;transcriptome;transcriptome sequencing;Uterus;Vagina;vaginal microbiota;Virulence;Virulence Factors;virulence gene;Woman;Work

PROJECT_TITLE: The impact of gestational diabetes on Group B Streptococcal virulence and host immune response

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal this training program is to produce a new generation of scientists who will elucidate the fundamental mechanisms that undergird health and disease by applying chemical biology tools to understand physiology, pathophysiology, and medicine. A unique aspect of this training program is that students receive training in both chemistry and physiology in a medical school environment.

PI_NAMEs: HABECKER, BETH A (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Chemicals;Physiology;Training Programs

PROJECT_TITLE: Chemical Physiology Training Program


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Shehzad Basaria, MD, is an endocrinologist at Brigham and Women's Hospital, Harvard Medical School, whose primary research and clinical interest over the last 20 years has focused on Gero-Oncology, including endocrine side effects of androgen deprivation therapy in men with prostate cancer and androgen deficiency in aging men (including those with cancer). This career development award will provide additional training and protected time for him to mentor trainees interested in patient-oriented research in the field of Gero-Oncology.

PI_NAMEs: BASARIA, SHEHZAD  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Age;age related;Aging;American;androgen deprivation therapy;Androgens;Area;Award;Baltimore;Benefits and Risks;Boston;Cancer Burden;Capsicum;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;Caring;Castration;Clinical;clinical center;clinical investigation;Clinical Research;Clinical Trials;Colorectal Cancer;cytokine;Data;debilitating symptom;Deposition;Deterioration;Diabetes Mellitus;Diagnosis;Disease;Endocrine;Endocrine System Diseases;Endocrinologist;Endocrinology;Enrollment;Environment;Erythropoiesis;Faculty;Fatigue;Fatty acid glycerol esters;Fatty Liver;Fostering;frailty;Functional disorder;Funding;General Population;Geriatrics;Goals;Grant;Health;High Prevalence;Hospitals;human old age (65+);Hypogonadism;improved;Incidence;Infiltration;Inflammation;Inflammatory;Infrastructure;Institution;Insulin Resistance;interest;International;Investigation;K-Series Research Career Programs;Longitudinal Studies;Lower Extremity;Magnetic Resonance Spectroscopy;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;medical schools;medical specialties;Medicine;men;Mentors;Mentorship;Metabolic;Metabolic syndrome;Metabolism;Metastatic Prostate Cancer;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Morbidity - disease rate;multidisciplinary;Muscle;muscle form;muscle strength;next generation;novel;older men;Oncology;Participant;patient oriented research;Physical Function;Physical Performance;Productivity;programs;prospective;Prostate;prostate cancer survivors;reduced muscle strength;Research;Research Institute;Research Personnel;Research Support;Resources;Role;Science;Series;side effect;Skeletal Muscle;skills;Testosterone;Thinness;Time;Tissues;Training;Translational Research;United States;United States National Institutes of Health;Upper Extremity;Urology;Woman;Work

PROJECT_TITLE: Mentoring in Endocrine and Cardiometabolic Abnormalities in Cancer and Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Precision Medicine;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Abnormalities of cardiac structure and impairment of cardiac function precede the development of heart failure (HF) and underlie HF subtypes. To identify specific genomic variants, captured by whole genome sequencing, associated with cardiac structure and function, as well as HF, will provide insights into the biological pathways underlying progressive cardiac dysfunction and HF and highlight targets for drug development. Furthermore, to incorporate cumulative genetic risk of cardiac structure and function alterations will improve HF risk prediction.

PI_NAMEs: RAMACHANDRAN, VASAN S;YU, BING  (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: adjudication;Affect;African American population;African ancestry;Age;Aging;Architecture;Atherosclerosis Risk in Communities;biobank;Biological;Cardiac;cardiovascular health;cohort;Cohort Analysis;Communities;Coronary Artery Risk Development in Young Adults Study;Data;Development;drug development;Drug Targeting;druggable target;Echocardiography;EchoGen;efficacious treatment;EFRAC;Elderly;Ethnic Population;European ancestry;Event;Framingham Heart Study;Future;Genes;Genetic;genetic architecture;genetic association;Genetic Determinism;Genetic Predisposition to Disease;Genetic Risk;genetic variant;genome sequencing;genome wide association study;genomic epidemiology;Genomics;Heart;Heart Abnormalities;Heart failure;heart function;Heritability;Hispanic ancestry;Hispanic Community Health Study/Study of Latinos;Impairment;improved;Incidence;inherited cardiomyopathy;insight;inter-individual variation;Investigation;Jackson Heart Study;Left Atrial Function;Left Ventricular Remodeling;Life Cycle Stages;lifetime risk;Machine Learning;machine learning algorithm;Measures;Mediating;Mendelian randomization;metabolomics;Minority;Mitochondrial DNA;Modeling;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;Myocardial dysfunction;novel;novel strategies;Pathogenesis;Pathway interactions;personalized intervention;Phenotype;phenotypic data;Physiology;polygenic risk score;population based;preservation;prevent;Prevention;programs;prospective;Proteins;Proteomics;Research;Right Ventricular Function;Risk;Risk Factors;risk prediction;Sampling;sex;Structure;trait;Trans-Omics for Precision Medicine;Underrepresented Populations;Variant;Veterans;whole genome

PROJECT_TITLE: Genetic Architecture of Cardiac Structure and Function and Its Impact on Heart Failure

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Thyroid cancer is the most common type of endocrine malignancy with poorly differentiated carcinoma and anaplastic carcinoma representing the most aggressive types of thyroid cancer. We have previously demonstrated that these cancer types can develop as a result of ALK gene fusions and established the mouse models of ALK-driven poorly differentiated and anaplastic carcinomas. In this proposal, will use this and the further improved mouse model to evaluate various therapeutic approaches to these frequently lethal forms of thyroid cancer.

PI_NAMEs: NIKIFOROV, YURI E (contact)

PROJECT_TERMS: Aggressive behavior;ALK gene;Anaplastic Carcinomas;anaplastic thyroid cancer;Animal Model;Animals;Appearance;Avidity;Behavior;Biological;Cancer Histology;cancer risk;cancer subtypes;cancer type;Carcinoma;Cells;Cessation of life;Clinical;Data;Death Rate;Diagnosis;Differentiated Gene;Differentiation Antigens;DNA copy number;Down-Regulation;Doxycycline;effective therapy;Endocrine;Excision;experimental study;FDA approved;Gene Fusion;Genes;Genetic;Human;Human Characteristics;I131 isotope;improved;Indolent;inducible gene expression;inhibitor;Iodine;Knock-out;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mutation;Neoplasm Metastasis;Neoplasms;new therapeutic target;novel;novel therapeutic intervention;Oncogenes;Papillary;Pathway interactions;Patients;Phosphotransferases;promoter;Radioactive Iodine;radioiodine therapy;response;restoration;Signal Transduction;SLC5A5 gene;Testing;Therapeutic;therapeutic target;Thyroglobulin;Thyroid Gland;Time;Transgenic Mice;treatment effect;tumor;tumor initiation;tumor progression;Undifferentiated;uptake;virtual;Withdrawal

PROJECT_TITLE: ALK Rearrangements in Aggressive Thyroid Cancer

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Oxygen imaging at high resolution can provide a fundamentally new insight into the action and effects of ultra- high dose rate FLASH radiation therapy and this project will examine the hypothesis that changes in oxygen fixation measurement could be used to control and optimize delivery of this treatment, optimizing it for future clinical translation.

PI_NAMEs: POGUE, BRIAN WILLIAM (contact);VINOGRADOV, SERGEI

PROJECT_TERMS: Acute;Biological Markers;biomaterial compatibility;Brain;cherenkov imaging;Clinical;clinical application;clinical translation;Clinical Trials;Colon;Consumption;conventional dosing;Data;Dedications;Dependence;detector;DNA Damage;Dose;Dose Rate;Electrons;Ensure;experimental study;Formulation;Future;Genetic Recombination;Goals;Hydrogels;Hypoxia;Image;imaging modality;Implant;In Vitro;in vivo;Injectable;insight;invention;Laboratories;luminescence;Lung;Maps;Measurement;Measures;Methods;Modeling;mouse model;Names;Normal tissue morphology;novel strategies;Optics;Organ;Oxygen;Oxygen Consumption;Oxygen saturation measurement;Partial Pressure;phosphorescence;Physiologic pulse;preservation;Protons;Publications;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radiobiology;Radiochemistry;recruit;repaired;Research;Resolution;Resources;Roentgen Rays;Role;sample fixation;serial imaging;Skin;System;Techniques;Technology;Testing;theories;Time;tissue oxygenation;Tissues;tool;treatment planning;tumor;Tumor Tissue;Variant;Wisconsin;Work

PROJECT_TITLE: Oxygen dynamics in FLASH radiotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-S(02)M]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Primary Health Care;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed project is relevant to public health because it will determine whether an adapted first-line PTSD intervention effectively treats COVID-related PTSD in frontline healthcare workers, thereby improving the health of these workers and their patients during the current pandemic and in anticipation of future public health emergencies. This innovative approach will leverage the existing resource of the employee assistance program to systematically and efficiently deliver first-line treatment where it is critically needed. It aligns with NIMH’s mission to test interventions for effectiveness in community practice settings and enhance the practical relevance of effectiveness research via deployment-focused, hybrid effectiveness-implementation studies.

PI_NAMEs: SRIPADA, REBECCA KAUFMAN (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Absenteeism;active duty;Address;Adherence;adverse outcome;Aftercare;Age;anxious;Area;brief intervention;burnout;Caring;clinical practice;clinically significant;Cognition;Community Practice;community setting;compare effectiveness;Consolidated Framework for Implementation Research;cost effective;cost effectiveness;Cost Effectiveness Analysis;COVID-19;COVID-19 pandemic;COVID-19 treatment;current pandemic;Data;design;disability;Distress;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness research;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Employee;Employee Assistance Program (Health Care);Ensure;Ethnic Origin;Evidence based treatment;experience;functional improvement;Future;future implementation;Goals;Health;health care service organization;Health Personnel;Health Resources;Healthcare Systems;Hybrids;implementation barriers;implementation efforts;implementation facilitators;implementation strategy;improved;Infrastructure;innovation;Intervention;Interview;Lead;Maps;Measures;Mediating;Mediator;medical specialties;Mental Health;Michigan;Military Personnel;military service;Mission;Modeling;National Institute of Mental Health;Occupations;pandemic disease;Patients;Performance at work;point of care;Population;Post-Traumatic Stress Disorders;practice setting;Primary Care;Procedures;Process;process evaluation;Professional counselor;programs;Public Health;public health emergency;Quality of life;Quality-Adjusted Life Years;Race;Readiness;reduce symptoms;Resources;service member;Severities;sex;Stress;Structure;Symptoms;telehealth;Testing;Therapeutic Effect;Time;Training;Trauma;trauma exposure;treatment as usual;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Reducing COVID-related PTSD symptoms in Frontline Healthcare Workers through Trauma-Focused Treatment in Employee Assistance Programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative Standard of care treatments (androgen deprivation therapy-ADT, chemotherapy) are initially effective for the treatment of bone metastatic prostate cancer (mPCa) but the disease evolves to become resistant and incurable due to cancer cell heterogeneity and bone ecosystem effects. To dissect the underlying complex interactions, we will generate a robustly parameterized and validated agent-based mathematical model that will allow us to understand the impact and role of the bone ecosystem and standard of care treatments on mPCa evolution. We will then use the math model to optimize and experimentally test evolutionary-informed standard of care adaptive care treatment strategies that will extend therapeutic efficacy and, ultimately, will translate into improving the overall survival of men suffering with incurable bone mPCa.

PI_NAMEs: BASANTA GUTIERREZ, DAVID ;LYNCH, CONOR C (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Algorithms;androgen deprivation therapy;Automobile Driving;Behavior;Biological;Biological Models;Biology;Biopsy;bone;bone cell;Bone Diseases;burden of illness;Calibration;cancer cell;cancer heterogeneity;Caring;Cell Line;cell type;chemotherapy;Clinical;clinical application;Clinical Trials;Coculture Techniques;Complex;Coupled;Data;data modeling;Diagnosis;Disease;Disease Progression;Disease Resistance;docetaxel;Dose;Ecosystem;effective therapy;Enantone;Enhancing Lesion;Evolution;experimental study;Flow Cytometry;Goals;Growth;Heterogeneity;Histologic;Histology;Human;human data;human disease;Hybrids;iliac artery;improved;in silico;In Vitro;in vivo;in vivo Model;innovation;Knowledge;Label;LAPC4;long bone;Malignant Bone Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Mathematics;men;Mesenchymal Stem Cells;mesenchymal stromal cell;Metastatic Prostate Cancer;Modeling;Monitor;Mus;novel;osteoblast differentiation;Osteoblasts;Osteoclasts;Outcome;Output;Pain;Phenotype;prevent;prostate cancer cell;prostate cancer cell line;Prostate Cancer therapy;refractory cancer;Refractory Disease;Resistance;response;Role;Schedule;single photon emission computed tomography;standard of care;Testing;therapy resistant;Time;Translating;Treatment Efficacy;treatment optimization;treatment response;treatment strategy;Tumor Burden;VCaP

PROJECT_TITLE: Defining bone ecosystem effects on metastatic prostate cancer evolution and treatment response using an integrated mathematical modeling approach


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: NEUROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: The BU ADRC provides a wide range of resources to support national AD/ADRD research and training priorities and performs deep phenotyping to address AD/ADRD heterogeneity and the effects of repetitive head impacts on cognitive decline and AD/ADRD using a broad array of complementary innovative approaches.

PI_NAMEs: MCKEE, ANN C. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: abeta deposition;Acceleration;Address;Advocacy;Affect;age related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;analytical tool;Biological;Biological Markers;biomarker discovery;Biometry;black women;Blood;Blood Vessels;Books;Boston;Brain Concussion;career development;catalyst;Cerebral Amyloid Angiopathy;chronic traumatic encephalopathy;Clinic;Clinical;Clinical Data;Cognitive;cohort;Collaborations;Communities;community engagement;Consultations;contact sports;Data;Data Collection;data management;Data Set;Deposition;Development;digital;digital data;digital health;Early identification;education research;Electroencephalography;Ensure;Environmental Risk Factor;experience;Exposure to;follow-up;Foundations;Framingham Heart Study;Funding;Future;General Population;Genetic;genetic profiling;Goals;Grant;Growth;head impact;health assessment;Heart;Heterogeneity;high risk;human subject;Impaired cognition;Individual;Infrastructure;innovation;interest;Late Effects;Lewy Body Disease;life span;Liquid substance;Magnetic Resonance Imaging;military service;Mission;Modeling;molecular phenotype;Molecular Profiling;motor neuron degeneration;Nature;neuroimaging;neuroinflammation;neuropathology;next generation;outreach;outreach program;Participant;Pathologic;Pathology;Phenotype;Positioning Attribute;Positron-Emission Tomography;prevent;Prevention;Privatization;programs;protein TDP-43;public-private partnership;Qualifying;Recommendation;recruit;Research;research clinical testing;Research Personnel;research study;Research Support;Resources;Risk;Risk Factors;Sampling;Scientist;Secure;Source;Specimen;Spinal Puncture;statistics;Strategic vision;symposium;tau Proteins;Tauopathies;Training;United States National Institutes of Health;Universities;Vascular Diseases;white matter;Women's Health

PROJECT_TITLE: Boston University Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KOWALL, NEIL W. (contact)

PROJECT_TERMS: Acceleration;Accountability;Action Research;Administrative Personnel;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Biological;black women;Boston;Budgets;career development;Clinical;cohort;Collaborations;Communities;Community Actions;community engagement;community organizations;cultural values;Data Set;Development;digital technology;disease heterogeneity;Early identification;Educational workshop;Ensure;Feedback;Fostering;Framingham Heart Study;Goals;head impact;Heart;Heterogeneity;high risk;high standard;human subject;improved;Individual;Industry;Infrastructure;innovation;Institution;Interactive Communication;International;Knowledge;Late Effects;Leadership;Medical center;medical schools;Mentors;Mission;Molecular Profiling;Monitor;Nature;next generation;novel;Performance;Policies;prevent;Prevention;Process;Process Assessment;Program Reviews;programs;public-private partnership;Qualifying;Recommendation;Reporting;Research;Research Ethics;Research Personnel;Resources;Review Committee;Role;Scientist;Self Assessment;Site;Source;Specimen;Strategic vision;Structure;symposium;Thinking;Training;United States National Institutes of Health;Universities;University adminstration;Women's Health;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

PHR: Narrative The proposed research educational program, Navigating Educational Trajectories in Neuroscience, facilitates the success of neuroscience scholars at two critical training periods within career advancement and progression: mid-stage training for graduate students and late-stage training for postdoctoral scholars. The cohort-based model – a key feature of the program’s design, given the integral nature of community to promote retention, resilience, and success among underrepresented trainees – integrates existing successful activities with new evidence-based practices in mentorship and core skill development to accelerate pre- and postdoctoral trainees’ success as they define and navigate their educational goals. By focusing on specific opportunities to improve training and resources for scholars from backgrounds underrepresented in neuroscience, we will contribute to the diversification of our region and nation’s biomedical workforce and enhance the skills and training of the next generation of neuroscience researchers in culturally-aware mentoring practices.

PI_NAMEs: NIELL, CRISTOPHER M;PFEIFER, JENNIFER HOPE (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Academia;academic standard;Acceleration;Active Learning;Awareness;career;Career Choice;career development;Career Mobility;Climate;Code;cohort;Communities;community building;Data Science;design;Development;disadvantaged background;Education;education pathway;education research;Educational Curriculum;Educational Status;Educational workshop;Enrollment;equity, diversity, and inclusion;evidence base;Evidence based practice;experience;Faculty;Fostering;Future;Goals;Graduate Education;graduate student;Grant;improved;improved outcome;innovation;Institution;Intervention;Investments;job market;Knowledge;Leadership;leadership development;Learning Module;member;mentoring community;Mentors;Mentorship;Minority Groups;minority scientist;model design;Modeling;Nature;Neurosciences;Neurosciences Research;next generation;Oregon;Participant;Pathway interactions;peer;Phase;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preparation;prevent;Productivity;programs;recruit;Reproducibility;Research;research and development;Research Personnel;Research Training;resilience;Resources;retention rate;Rotation;Scientist;Series;skill acquisition;skills;STEM field;Structure;Students;success;Talents;therapy design;Time;Training;training opportunity;Training Programs;Universities;Writing


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative: The propensity of the airways to narrow in response to exercise and other endogenous triggers such as allergens is known as indirect airway hyperresponsiveness. This research will lead to a better understanding of the immunopathology of this fundamental aspect of asthma and will train and support the career development of patient-oriented researchers in asthma.

PI_NAMEs: HALLSTRAND, TEAL S (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abbreviations;Aerosols;afferent nerve;Air;airway epithelium;airway hyperresponsiveness;airway inflammation;airway obstruction;Allergens;Allergic;Asthma;asthmatic;asthmatic airway;Biopsy Specimen;Bronchoconstriction;Bronchoconstrictor Agents;career development;Cell Culture Techniques;Cell secretion;Cells;cytokine;design;Dryness;eicosanoid metabolism;Environment;Enzyme Inhibitor Drugs;Enzymes;eosinophil;Epithelial Cells;Epithelium;Exercise;extracellular;Gene Expression;Generations;Genes;Genomics;Goals;Human;Hyperpnea;Immune;immunopathology;Individual;Infiltration;Inflammation;interest;Laboratories;lipid mediator;Location;Lysophospholipids;Macrophage;mast cell;Measures;Mediating;Mediator;Metabolism;methacholine;Modeling;MUC5AC gene;Mucins;Names;Nerve;Neurokinin A;next generation;patient oriented;Patients;peripheral blood;Phenotype;Phospholipase A2;Phospholipid Metabolism;Physiology;Play;Pre-Clinical Model;programs;proliferation potential;Research;Research Personnel;respiratory smooth muscle;response;Risk;Role;Sampling;Severities;small molecule inhibitor;Source;stem cells;Structure;Submucosa;Substance P;Symptoms;TAC1 gene;Therapeutic;Training;training opportunity;transcriptomics

PROJECT_TITLE: Immunopathology of Indirect Airway Hyperresponsiveness in Asthma

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: MEZ, JESSE BENJAMIN (contact)

PROJECT_TERMS: 3-Dimensional;Address;Administrative Supplement;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Automobile Driving;Award;Biological Markers;biomarker validation;blood product;Boston;Brain;Brain imaging;Catchment Area;Cerebrospinal Fluid;chronic traumatic encephalopathy;Clinic;Clinical;clinical center;Clinical Investigator;clinical phenotype;Clinical Research;Cognition;Cognitive;cohort;Collaborations;Collection;Consensus;Consent;contact sports;Cross-Sectional Studies;Data;data management;data sharing;Dementia;Diagnosis;diagnostic signature;digital;digital phenotyping;education research;Electroencephalography;Ensure;Evaluation;Exposure to;Framingham Heart Study;Funding;Genetic;Genomics;Goals;head impact;health disparity;informant;insight;Knowledge;Late Effects;Life;male;Manufactured football;Medical center;Memory;Memory Disorders;men;Methods;mild cognitive impairment;military service;Molecular Profiling;Neighborhoods;Neurologic;neuropathology;neuropsychiatry;Neuropsychology;next generation;novel;novel marker;outreach;Participant;Pathogenesis;Pathologic;Phenotype;Play;Population Study;Positron-Emission Tomography;precision medicine;Race;Recommendation;recruit;Reporting;Research;Research Personnel;research study;Risk Factors;Role;Sampling;Source;Sports;statistics;student training;Target Populations;tau Proteins;Translational Research;transmission process;Universities;Violence;Woman;Work

PROJECT_TITLE: Core B: Clinical Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

PHR: The studies in this proposal seek to understand the early pathogenic mechanisms underlying the polyglutamine neurodegenerative disease, Spinocerebellar Ataxia type 3, so that disease-slowing therapies targeting the most promising molecular and cellular targets can be developed for this fatal disorder. Insights from the proposed work also may provide insight into related polyglutamine diseases.

PI_NAMEs: MCLOUGHLIN, HAYLEY SARAH (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Animal Model;Antioxidants;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;Behavioral;Biological Markers;Biological Models;brain cell;Brain Diseases;brain dysfunction;Brain region;CAG repeat;Cell Death;Cell Lineage;Cell model;Cells;cellular targeting;Complex;Coupled;data modeling;Defect;Disease;DNA Damage;Early identification;Epigenetic Process;Functional disorder;Genes;Glutathione;Histopathology;Human;human disease;Huntington Disease;Hypermethylation;imaging study;Impairment;insight;Investigation;knock-down;Knock-out;Lead;Machado-Joseph Disease;Magnetic Resonance Imaging;Modeling;Modification;Molecular;Molecular Target;mortality;motor behavior;mouse model;Mus;mutant;Mutation;Myelin Proteins;Nerve Degeneration;Neuroglia;Neuronal Dysfunction;novel;oligodendrocyte lineage;Oligodendroglia;overexpression;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Patients;polyglutamine;polyglutamine neurodegenerative diseases;Posterior Fossa;Primary Cell Cultures;Proteins;Reporter;Research;Research Personnel;response;Route;Series;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;Transgenic Organisms;white matter;Work

PROJECT_TITLE: Nonneuronal Mechanisms of Polyglutamine Neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Hepatitis B virus (HBV) is a small enveloped DNA virus responsible for chronically infecting over 250 million individuals worldwide. Our proposal aims to elucidate the entry steps for HBV in susceptible cells and how these steps are blocked in non-susceptible cells. Our project will provide the basis for identifying how the viral capsid can direct endosomal trafficking post internalization, a novel proposal in the field of HBV and we will further develop an efficient in vitro infection model and identify novel host determinants that play a role in HBV entry.

PI_NAMEs: MCGINLEY, MEGAN  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Anti-viral Therapy;antiviral drug development;Autophagosome;Back;Binding;Biological Assay;Bypass;Capsid;Cell Fractionation;Cell Nucleus;Cell Separation;Cell surface;Cells;Cessation of life;Chemistry;Chronic;Circular DNA;Cirrhosis;clinical development;Confocal Microscopy;Core Protein;Cytoplasm;design;differential expression;DNA;DNA Viruses;Doctor of Philosophy;Early Endosome;Electron Microscopy;Endocytosis;Endosomes;Event;Family;Genes;Genetic Transcription;Hepadnaviridae;Heparan Sulfate Proteoglycan;Hepatitis B Virus;Hepatocyte;hepatoma cell;HepG2;Human;Impairment;In Vitro;Individual;Infection;inhibitor;insight;Integration Host Factors;Kinetics;late endosome;Life Cycle Stages;Liver diseases;Mediating;Membrane Fusion;Membrane Proteins;Modeling;Monitor;multicatalytic endopeptidase complex;mutant;Mutation;Na(+)-taurocholate-cotransporting peptide;novel;Nuclear Import;Nucleocapsid;particle;Pathway interactions;Phenocopy;Phenotype;Predisposition;Primary carcinoma of the liver cells;Process;Production;Productivity;receptor;Recycling;Relaxation;Replicon;Reporter;Research;Role;Route;Series;small molecule;Specific qualifier value;Supporting Cell;System;Testing;Tissues;trafficking;transcriptome sequencing;Transfection;Translations;Viral;Viral Genome;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Viral and Host Determinants of Endosomal Trafficking during HBV Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: TRIPODIS, YORGHOS  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;analytical tool;Area;Basic Science;Bioinformatics;Biometry;Boston;Clinical Research;cohort;Collaborations;Computer software;cost;Data;Data Analyses;Data Analytics;Data Collection;data exploration;data management;Data Management Resources;data quality;Data Security;Data Set;data sharing;Data Sources;data visualization;database design;Databases;design;Development;diverse data;E-learning;education research;Effectiveness;electronic data;Ensure;experience;Experimental Designs;Faculty;Funding;Genomics;Image;improved;Information Systems;Infrastructure;Ingestion;instrument;Joints;Lead;Leadership;longitudinal analysis;Machine Learning;machine learning algorithm;machine learning method;Manuscripts;Methodology;Methods;Mission;Modeling;novel;Participant;Persons;Phase;phenotypic data;Population;Practice Management;Preparation;Procedures;Productivity;Publications;Qualifying;quality assurance;Quality Control;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientific Advances and Accomplishments;Secure;Security;Selection Bias;software infrastructure;Software Tools;sound;Specimen;Statistical Data Interpretation;statistics;System;Techniques;Tissues;Training;Translational Research;Universities;user-friendly;web platform;Writing

PROJECT_TITLE: Core C: Data Management and Statistical Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.

PI_NAMEs: ELDAIEF, MARK CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Anhedonia;Behavior;Behavior assessment;Behavioral;behavioral outcome;Brain;Cerebral cortex;Clinical;clinical effect;clinical practice;Clinical Trials;Data;Depressed mood;Derivation procedure;design;Exhibits;experience;FDA approved;Foundations;Functional disorder;functional outcomes;Image;Individual;individualized medicine;Left;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mediating;Mental Depression;Mental disorders;Methods;Modeling;network models;Neurobiology;neuropsychiatric disorder;Neuropsychological Tests;Neuropsychology;neuroregulation;Neurosciences;Noise;Outcome Measure;Pathogenicity;Patients;Performance;Play;precision neuromodulation;Prefrontal Cortex;Psychopathology;Questionnaires;repetitive transcranial magnetic stimulation;Research Domain Criteria;Resolution;Rest;reward anticipation;Rewards;Role;Self Perception;Short-Term Memory;Signal Transduction;Symptoms;Testing;Therapeutic Effect;Time;Work

PROJECT_TITLE: Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric Disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PROJECT_TERMS: abeta deposition;Address;age related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Argyrophilic Grain Disease;Astrocytes;Biochemical;Biological Assay;Biological Markers;biomarker development;Blood Vessels;Boston;Brain;Brain Concussion;Cerebral Amyloid Angiopathy;chronic traumatic encephalopathy;Clinic;Clinical;Collaborations;Communication;Communities;contact sports;corticobasal degeneration;cytokine;Data;data management;Diagnosis;Diagnostic;diagnostic criteria;digital;Digital Libraries;DNA;Doctor of Philosophy;education research;Environmental Risk Factor;Epitopes;Evaluation;Exposure to;Family member;Fostering;Foundations;Framingham Heart Study;Frontotemporal Lobar Degenerations;Funding;Genetic;genetic risk factor;Goals;head impact;high resolution imaging;hippocampal sclerosis;Image;improved;Infrastructure;innovation;International;Investigation;Knowledge;Leadership;Lewy Body Disease;Long-Term Effects;Measures;member;Methods;Microvascular Dysfunction;military service;Molecular Profiling;Myelin;Nerve Degeneration;Nervous System Trauma;neuroinflammation;neuropathology;next generation;novel marker;Outcome;outreach;Pathology;Phenotype;phenotypic data;Prion Diseases;programs;Progressive Supranuclear Palsy;protein TDP-43;Qualifying;recruit;Research;Research Personnel;Resources;Risk Factors;RNA;Role;Scientist;skills;Slide;statistics;System;tau Proteins;Tauopathies;Tissues;Training;Trauma;United States National Institutes of Health;Universities;white matter;Work

PROJECT_TITLE: Core D: Neuropathology Core


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE There is a critical need for a diverse group of highly trained basic and clinical oral health researchers. If effective preventive therapies and cures for the many diseases associated with the oral, dental and craniofacial complex are to be discovered and applied, a cadre of oral health researchers must be trained to work in interdisciplinary teams and to maintain the highest standards for ethical and responsible conduct of rigorous scientific research. The main objective of this comprehensive training program is to produce oral health researchers who can apply state-of-the-art technologies to generate new knowledge, translate that information to applied therapies, and rigorously evaluate the outcomes of implementation of novel preventive or treatment strategies to improve human health.

PI_NAMEs: LEMOS, JOSE A (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Appointment;Area;Autoimmunity;Biology;Biomedical Engineering;biomedical informatics;bone;career;Clinical;clinical investigation;Clinical Sciences;college;Communicable Diseases;Computational Biology;craniofacial;craniofacial complex;Dental;Dentistry;Detection;Disease;Doctor of Philosophy;doctoral student;Education;experience;flexibility;Florida;Goals;Head and Neck Cancer;Health;Human Microbiome;implementation science;Individual;Interdisciplinary Study;Knowledge;Medicine;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral;oral biology;Oral health;oral infection;post-doctoral training;Postdoctoral Fellow;Prevention;Productivity;programs;Research;Research Personnel;Resources;response;Salivary Glands;Science;Scientist;skills;stem cell biology;Students;Training;Training Programs;Translating;Translational Research;Universities;virology

PROJECT_TITLE: Comprehensive Training Program in Oral Biology


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lupus;Racial and Ethnic Minority Health Research

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative This study will determine the cellular and molecular mechanisms by which genetic variants for the ABIN1 gene TNIP1 regulates monocyte, neutrophil and B cell activity in lupus nephritis. Successful completion of this study will define novel and precision diagnostics and targets for the treatment of high-risk African American systemic lupus erythematosus patients with lupus nephritis.

PI_NAMEs: CASTER, DAWN ;POWELL, DAVID W. (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;African American;African American population;Alleles;Animal Experiments;Animals;anti-dsDNA antibodies;Autoimmunity;B-Lymphocytes;Binding Proteins;Biological Response Modifiers;Blood;Bone Marrow;caucasian American;Cell Maturation;Cell Physiology;Cell Separation;cell type;Cells;chemokine;Clinical;cohort;Complication;CXCL10 gene;CXCR3 gene;cytokine;Data;Development;diagnostic biomarker;Diffuse;Disease;Disease Outcome;disorder risk;Event;experimental study;Functional disorder;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;genetic variant;Genotype;Glomerulonephritis;high risk;Human;Immune;Immune Complex Glomerulonephritis;Inflammation Mediators;Inflammatory;inhibitor;insight;Interleukin-6;Investigation;Kidney;Kidney Failure;Knowledge;Lupus Nephritis;Mature T-Lymphocyte;Mediating;Molecular;monocyte;Mus;Mutation;Nature;neutrophil;novel diagnostics;Nuclear;Outcome;Pathologic;Patients;Peripheral;personalized diagnostics;Physiological;podocyte;Polyubiquitin;Precision therapeutics;Predisposition;Production;Prognosis;protein function;Proteins;Proteinuria;Publishing;Race;racial disparity;Regulation;Reporting;Research Personnel;Risk;risk variant;Role;Sampling;Scientist;Serum;Severities;Severity of illness;Systemic Lupus Erythematosus;T-Lymphocyte;Target Populations;therapeutic target;TNF gene;Transcriptional Regulation;Transgenic Mice;Transgenic Organisms;Transplantation;Validation;Variant;Wild Type Mouse

PROJECT_TITLE: ABIN1 dysfunction in Lupus Nephritis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: BUDSON, ANDREW  (contact)

PROJECT_TERMS: Address;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;anti-racism;Awareness;Biological Markers;Black race;Books;Boston;Brain;Brain Concussion;catalyst;chronic traumatic encephalopathy;Cities;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;Cognitive;cognitive change;cohort;Collaborations;Communities;Community Actions;community center;Country;Data;data management;Diagnosis;Disclosure;education research;Educational workshop;effectiveness evaluation;Ensure;Event;Family;Foundations;Funding;Genetic;genetic testing;Goals;head impact;health disparity;Health Professional;Healthcare Systems;high risk;Individual;innovation;insight;Knowledge;lectures;Massachusetts;Memory;Methods;military service;neuropathology;New Hampshire;Newsletter;novel;outreach;Pamphlets;Paper;Participant;participant enrollment;participant retention;Patient Recruitments;Persons;pharmacologic;Population Study;Positron-Emission Tomography;Precision Health;precision medicine;prevent;Printing;Procedures;Professional Education;programs;racial population;recruit;Reduce health disparities;Registries;Research;Research Project Grants;Sampling;screening;Series;social media;Spinal Puncture;Standardization;statistics;Students;symposium;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Veterans;web site;Work

PROJECT_TITLE: Core E: Outreach and Recruitment Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: GOLDSTEIN, LEE E. (contact)

PROJECT_TERMS: accurate diagnosis;Address;Ally;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Atrophic;Biological Markers;biomarker development;biomarker discovery;biomarker identification;biomarker validation;Biometry;Blood;Boston;Brain imaging;brain volume;Cells;Cerebrum;chronic traumatic encephalopathy;Clinical;clinical development;Clinical Research;cohort;Collaborations;Communities;cost effective;Data;data management;data sharing;Dementia;Detection;Development;Diagnosis;Differential Diagnosis;Disease;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Early Intervention;Early treatment;early-career faculty;Education;education research;Emerging Technologies;entorhinal cortex;exosome;experience;Faculty;Generations;Genetic;Goals;Hippocampus;Human;Image;Imaging Techniques;improved;insight;Institution;interest;International;Ligand Binding;Light;Liquid substance;Magnetic Resonance Imaging;Measures;member;Mentorship;Mission;Molecular Profiling;Monitor;MRI Scans;multimodality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurofilament;neuroimaging;neuroimaging marker;Neurons;neuropathology;next generation;normal aging;novel;Participant;Peptides;personalized medicine;Plasma;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;prevent;Process;Protocols documentation;Qualifying;Research;research clinical testing;Research Personnel;Resources;response;Risk Assessment;Scientist;Serum;Specimen;Staging;statistics;Targeted Research;tau Proteins;tau-1;Testing;Therapeutic;Thick;Training;United States National Institutes of Health;Universities;Update;Ventricular;white matter

PROJECT_TITLE: Core F: Biomarker Core


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Dietary Supplements;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally and it can progress to the more severe form called non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Fructose intake promotes NAFLD progression. Our studies suggest nearly half of the patients with NAFLD may have reduced S-adenosylmethionine (SAMe) level in the liver. The ultimate goal of this project is to understand how low liver SAMe level affects progression of NAFLD by fructose, and how it promotes the development of fibrosis and liver cancer.

PI_NAMEs: LU, SHELLY CHI-LOO (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Affect;Aldolase B;Anabolism;Area;Biological;Catabolism;cell growth;Cell Proliferation;Child;Chronic;chronic liver disease;Cirrhosis;Consumption;Data;Development;Disease Progression;Educational process of instructing;enzyme activity;Enzymes;Family member;Fatty Acids;Fatty Liver;Fibrosis;Fructose;Funding;Glucose;glycine N-methyltransferase;Goals;Grant;Hepatic;Homeostasis;Human;improved;In Vitro;in vivo Model;insight;Intake;Invaded;Knock-out;Knockout Mice;Link;Liver;Liver diseases;liver injury;Malignant neoplasm of liver;Mediating;Messenger RNA;Metabolism;metabolomics;Methionine;methionine adenosyltransferase;Methylation;migration;Modeling;mouse model;Mus;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;overexpression;oxidation;Paper;Patients;Phosphorylation;Phosphotransferases;Play;Polyamines;Primary carcinoma of the liver cells;Prognosis;programs;Protein Methylation;Proteins;Public Health;Reaction;Reporting;repository;response;Ribonucleoproteins;Ribosomal Proteins;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serum;Site;Specimen;Structure;Testing;Translations

PROJECT_TITLE: Role of SAMe in the Progression of Nonalcoholic Fatty Liver Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAO PAULO

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: UNIVERSITY OF SAO PAULO

PHR: PROJECT NARRATIVE Chagas disease (CD) is a major public health burden in Latin America and a serious emerging threat to several countries worldwide, including the United States. Current treatments have limited efficacy and display high toxicity and this project seeks to address this by validating Trypanosoma cruzi dihydroorotate dehydrogenase (TcDHODH) as a drug target against CD. Through the development of selective and potent TcDHODH inhibitors with appropriate ADME/tox properties and in vivo proof-of-concept, our proposal aims to offer a novel route for drug development against CD and a starting point for lead optimization, thus helping the poorest and most vulnerable people in our society and strengthening capacity in the field of drug discovery in Brazil.

PI_NAMEs: EMERY, FLAVIO DA SILVA;NONATO, MARIA CRISTINA (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acrylamides;Active Sites;Acute;Address;Affect;Anabolism;Animal Disease Models;Antiparasitic Agents;Binding;Biological Assay;Blood;Brazil;Cell Culture Techniques;Cells;Chagas Disease;Chemical Structure;Chemicals;Chronic;Chronic Phase;Collaborations;Communities;Complex;computational chemistry;Computer Assisted;Computer Models;Country;Cysteine;cytotoxicity;Data;data portal;design;Developing Countries;Development;DHODH gene;dihydroorotate;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;Disease;divinyl sulfone;Dose;drug development;drug discovery;Drug Kinetics;drug metabolism;Drug Targeting;drug-like compound;effective therapy;efficacy evaluation;Enzymatic Biochemistry;Enzyme Inhibition;Enzymes;Equilibrium;Etiology;fighting;Flavin Mononucleotide;flexibility;Fumarates;Funding;Generations;Genetic study;Goals;Hot Spot;in silico;in vitro activity;in vivo;Infection;inhibitor;Institution;Kinetics;Knowledge;Latin America;Lead;lead optimization;Libraries;Ligands;Mammalian Cell;Maps;Measures;Metabolic Activation;Metabolism;Methods;mouse model;multidisciplinary;neglect;new therapeutic target;Nitriles;novel;orotate;Outcome;oxidation;Oxidation-Reduction;Parasitic Diseases;Parasitology;Pathogenesis;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Poverty;Predisposition;Property;Public Health;public-private partnership;Pyrimidine;Pyrimidine Nucleotides;rational design;Reaction;Regimen;Research;Research Personnel;resistant strain;Route;Running;screening;side effect;Societies;Solvents;structural biology;Structure;Succinate Dehydrogenase;Succinates;Techniques;Testing;Time;tool;Toxic effect;Treatment Protocols;Trypanosoma cruzi;United States;Validation;Vulnerable Populations;X-Ray Crystallography

PROJECT_TITLE: Validation of Trypanosoma cruzi dihydroorotate dehydrogenase as a drug target for Chagas´disease.

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PI_NAMEs: FARRER, LINDSAY A. (contact)

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;analysis pipeline;Area;Behavior;biobank;Biocompatible Materials;Bioinformatics;Biological;Biological Markers;Biology;Blood;Boston;Brain;Cell Nucleus;Clinical;Clinical Trials;cluster computing;cohort;Collaborations;Collection;Communities;Complex;Core Facility;Correlation Studies;cost;Data;Data Analyses;data management;Data Set;Database Management Systems;Databases;Dementia;design;Diagnosis;Disease;DNA;DNA Sequence;drug development;Drug Targeting;Early Diagnosis;Early treatment;effective therapy;endophenotype;Epigenetic Process;epigenomics;Etiology;exome;expectation;Foundations;Generations;Genetic;genetic analysis;Genetic Diseases;genetic information;Genetic Materials;genetic profiling;Genetic Research;genetic resource;genetic risk factor;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Heterogeneity;Individual;individualized medicine;Infrastructure;Investigator-Initiated Research;Knowledge;Laboratories;Libraries;Link;lipidomics;Malignant Neoplasms;Management Information Systems;Methods;methylomics;MicroRNAs;Molecular;Molecular Genetics;Molecular Profiling;neuropathology;Participant;Pathway interactions;personalized medicine;Phenotype;precision medicine;preservation;Process;programs;protective factors;rapid growth;repository;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Risk Factors;RNA;RNA Sequences;Saliva;Sampling;sound;Specimen;statistics;Targeted Research;Technology;Training and Education;transcriptomics;translational study;Universities;Vertebral column;Vision;whole genome;Work

PROJECT_TITLE: Core G: Genetics and Molecular Profiling


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Cancer patients taking a class of chemotherapeutic drugs called Tyrosine Kinase Inhibitors (TKIs) often experience taste dysfunction, or dysgeusia, that can severely impact quality of life and lead to poor treatment outcomes. Very little is known about the role of tyrosine kinases in taste homeostasis, and the lack of an identified causative mechanism for how TKIs disrupt taste makes dysgeusia a difficult symptom to treat. This proposal seeks to characterize the role of the receptor tyrosine kinase c-Kit in taste homeostasis and identify the mechanism by which TKIs disrupt taste, which ultimately could inform efforts to lessen the burden of TKI treatment.

PI_NAMEs: PIAROWSKI, CHRISTINA M (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;Affect;Behavioral;Binding;Cancer Patient;Categories;Cell Death;Cell Differentiation process;Cell Survival;cell type;Cells;Cellular Assay;Cellular biology;Cre driver;Data;Differentiation Antigens;Disease;Dysgeusia;Electrophysiology (science);Environment;experience;experimental study;Functional disorder;Genetic;Homeostasis;Human;in vivo;KDR gene;Knock-out;Lead;Ligands;Mediating;Metastatic Renal Cell Cancer;Modeling;Monitor;Mus;Nerve;novel;Organoids;Patients;Pharmaceutical Preparations;pharmacologic;Platelet-Derived Growth Factor alpha Receptor;Play;precursor cell;Predisposition;preference;prevent;progenitor;Protein Tyrosine Kinase;Proto-Oncogene Protein c-kit;Quality of life;Receptor Cell;Receptor Protein-Tyrosine Kinases;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Specific qualifier value;Stem Cell Factor;stem cell proliferation;stem cells;Supporting Cell;sweet taste perception;Symptoms;Taste Buds;Taste Perception;taste system;Testing;Therapeutic;Time;Tissues;Tongue;Treatment outcome;Tumor Angiogenesis;Type II Epithelial Receptor Cell;Type III Epithelial Receptor Cell;Tyrosine Kinase Inhibitor;Tyrosine Kinase Receptor Inhibition

PROJECT_TITLE: Not so sweet: Investigating the role of c-Kit in sweet cell homeostasis


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: At least one in five children and adolescents in the United States suffer from a serious mental or neurodevelopmental disorder; these disorders not only affect children and their families but lead to far-reaching, negative educational, financial, vocational and societal outcomes. To promote prevention, identification and effective treatment of children with these disorders, we need committed and productive basic, translational and clinical research scientists. This T32 program directly addresses this need by training early career investigators to have the knowledge and skills necessary to conduct innovative, interdisciplinary and precision health-oriented research at the forefront of child psychiatry and neurodevelopment.

PI_NAMEs: REISS, ALLAN L (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Research Training for Child Psychiatry and Neurodevelopment


PI_NAMEs: O'CONNOR, MAUREEN KATHELEEN (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Attention;Basic Science;Behavioral;Biological Markers;Biometry;Boston;career;chronic traumatic encephalopathy;Clinical;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Data;data management;Data Set;Dementia;Detection;digital;early-career faculty;education research;Enrollment;Ensure;Environment;experience;Faculty;Feedback;Framingham Heart Study;Functional disorder;fundamental research;Genetic;Goals;human subject;Instruction;interest;knowledge base;Longitudinal cohort study;Mentors;Mentorship;Monitor;Nerve Degeneration;Neurodegenerative Disorders;next generation;novel therapeutics;Pathology;Population;Population Heterogeneity;Postdoctoral Fellow;programs;Research;Research Personnel;Research Training;Resources;responsible research conduct;Risk Factors;Rotation;Scientist;skills;Structure;symposium;Symptoms;Training;Training and Education;Translational Research;Underrepresented Populations;Universities;Vulnerable Populations

PROJECT_TITLE: RL5: Research Education Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Pediatric;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE This project tests the hypothesis that, in the rat, exposure to alcohol during adolescence induces long-term changes in sleep and activity rhythms, increases in drinking, that are in part mediated by hypocretin/Orexin system in key sleep circuits. These studies also test new therapeutics for adolescent alcohol-induced sleep/wake pathology.

PI_NAMEs: EHLERS, CINDY L (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Adolescence;Adolescent;adolescent alcohol initiation;Adult;Alcohol consumption;alcohol effect;alcohol exposure;alcohol monitoring;alcohol seeking behavior;alcohol use disorder;Alcohols;Animal Model;antagonist;Arousal;ATAC-seq;Behavioral;binge drinking;Bite;Chronic;Clinical;Clinical Research;Complex;craving;Data;Devices;Dose;drinking;drinking behavior;Drowsiness;efficacy evaluation;Electroencephalography;Epigenetic Process;Etiology;evidence base;Female;follow-up;frontal lobe;Gene Expression;Genetic;Heavy Drinking;Hematocrit procedure;Human;human subject;hypocretin;Hypothalamic structure;improvement on sleep;indexing;Individual;knock-down;Laboratories;Long-Term Effects;Maintenance;male;Measures;Mediating;Modeling;Monitor;neural;Neuroanatomy;novel therapeutics;older adult;Pathology;Peptides;personalized medicine;pharmacologic;Pharmacology Study;Physiological;Polysomnography;Rattus;receptor;Receptor Gene;Role;SB-334867;Severities;sex;Sleep;Sleep disturbances;Sleep Wake Cycle;Sleeplessness;Small Interfering RNA;sobriety;Specificity;Suggestion;System;Testing;theories;Therapeutic Intervention;Time;transcriptome sequencing;underage drinking;vapor;Wakefulness;whole genome;Withdrawal;young adult

PROJECT_TITLE: Effects of alcohol on sleep/activity rhythms: Focus on Hypocretin/Orexin

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_CITY: SAN DIEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE  Mutations in isocitrate dehydrogenase (IDH) affect patients with gliomas, chondrosarcomas, and acute myeloid leukemia, but the mechanistic consequences of these mutations are still being explored. We propose to leverage our recent discoveries on IDH to elucidate the molecular, trans-organellular, and cellular mechanisms of dysfunction. This work is expected to establish the fundamental features of IDH mutations, ultimately providing tools for predicting patient prognosis and illuminating new disease-driving pathways.

PI_NAMEs: SOHL, CHRISTAL DYANE (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;alpha ketoglutarate;Automobile Driving;Catalysis;Chemicals;Chondrosarcoma;Clinic;Communication;Cytosol;Disease;DNA;Drug Targeting;Enzymes;Functional disorder;Glioma;Goals;Grant;Health;histone demethylase;inhibitor;Isocitrate Dehydrogenase;Isocitrates;Kinetics;lipid biosynthesis;Lipids;Location;loss of function;Malignant Neoplasms;Metabolic;Mitochondria;Modification;Molecular;mutant;Mutation;NADP;Organelles;Oxidative Stress;Pathway interactions;patient prognosis;Patients;peroxisome;Point Mutation;predictive tools;Production;programs;Property;Protein Dynamics;Regulation;Reporting;Research;Role;Signal Transduction;Stress;Technology;Therapeutically Targetable;tool;Tumor Suppressor Genes;Variant;Work

PROJECT_TITLE: Isocitrate dehydrogenase (IDH) mutations as drivers of organelle stress and dysfunction"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Over 600,000 people in the U.S. have kidney failure that requires dialysis or transplantation to stay alive. The purpose of this project is to determine why kidneys fail. In particular, we plan to study biochemical pathways that prevent kidney cells from dying, which may lead to new therapies to halt the progression of kidney diseases.

PI_NAMEs: SCHELLING, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Albumins;Albuminuria;Apical;Apoptosis;ATP Synthesis Pathway;Atrophic;Autophagocytosis;basolateral membrane;Binding;Biochemical Pathway;Biological Assay;Cell Line;Cells;Ceramides;Complementary DNA;Complex;Cytoplasm;cytotoxic;cytotoxicity;Data;Diabetes Mellitus;Diabetic Nephropathy;Dialysis procedure;Diglycerides;disease model;Disease Progression;Docking;Dose;End stage renal failure;endoplasmic reticulum stress;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Exposure to;fasting glucose;Fat-Restricted Diet;fatty acid transport;fatty acid-transport protein;Fibrosis;Filtration;Functional disorder;Genetic;Gluconeogenesis;Glucose;Glycolysis;Glycosuria;High Fat Diet;Histology;Hypoglycemia;improved;In Vitro;in vivo;Injections;injured;Injury;interstitial;Kidney;kidney cell;kidney cortex;Kidney Diseases;Kidney Failure;knock-down;Lipids;long chain fatty acid;loss of function;LoxP-flanked allele;Maintenance;Mediating;Metabolic;Metabolism;Mitochondria;mortality;mouse model;Mouse Strains;Mus;Nonesterified Fatty Acids;novel therapeutics;overexpression;oxidation;Palmitates;Pathology;Pathway Analysis;perilipin;Permeability;Persons;Phenotype;Plasma;prevent;Process;promoter;Proteins;Renal function;Risk;Role;small hairpin RNA;Streptozocin;Superoxides;Tamoxifen;Therapeutic;Tissues;transcriptome sequencing;transgene expression;Transgenic Mice;Transplantation;Triglycerides;Tubular formation;uptake

PROJECT_TITLE: Mechanisms of Tubular Atrophy

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Excess lipid accumulation in liver and intestine is linked to diabetes, NASH, and other diseases. We have discovered a family of mammalian proteins called Asters that plays an important role in cholesterol movement. We will determine the roles that Asters play in lipid homeostasis in the enterohepatic axis, test whether Asters are important contributors to the pharmacological effects of LXR and FXR agonists, and assess whether Asters may be potential drug targets themselves.

PI_NAMEs: TONTONOZ, PETER J (contact)

PROJECT_TERMS: absorption;Adrenal Cortex;Affect;Agonist;apical membrane;basolateral membrane;Bile Acids;Bile fluid;Binding;Biochemical;Biological;Cell membrane;cell type;Cells;Cholesterol;cholesterol absorption;Cholesterol Esters;Chylomicrons;Complex;Data;Development;Diabetes Mellitus;Dietary Cholesterol;Dietary Fats;Disease;Drug Targeting;Endocrine;Enterocytes;Excretory function;ezetimibe;Family;Gastrointestinal Diseases;Gene Expression;Genes;Genetic Transcription;gut inflammation;HDL receptor;Hepatic;Hepatocyte;High Density Lipoprotein Cholesterol;Homeostasis;Image;in vivo;inhibitor;insight;Intervention;Intestines;Knockout Mice;Ligands;Link;lipid metabolism;lipid transport;Lipids;Liver;Malignant Neoplasms;Mammals;Membrane;Metabolic;Metabolic Diseases;Metabolism;Molecular;Movement;Mus;nonalcoholic steatohepatitis;novel;Nuclear Hormone Receptors;Nuclear Pore Complex;Nuclear Receptors;overexpression;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Plasma;Play;Production;protein transport;Proteins;Reagent;receptor;recruit;Regulation;Reporting;Resolution;response;reverse cholesterol transport;Role;Series;Signal Transduction;Small Intestines;small molecule inhibitor;SR-BI receptor;Steroid biosynthesis;Sterols;Structure;Testing;Therapeutic Intervention;Tissues;Tracer;Triglycerides;uptake;vesicle transport

PROJECT_TITLE: The Nuclear Receptor-Aster Pathway in Enterohepatic Metabolism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative One of the earliest symptoms of Alzheimer’s disease to appear is deficits in spatial navigation, or getting lost in space, which involves complex interactions across multiple brain regions. This research project will look at how these interactions may be affected by Alzheimer’s disease, causing losses in spatial navigation, and will utilize a noninvasive approach for clearing amyloid beta and tau and rescuing functional interactions. This research will also expand our understanding of Alzheimer’s effects on spatial navigation, and will aid in understanding what mechanisms underlie these deficits, to improve early identification and treatment strategies.

PI_NAMEs: CUSHING, SARAH DANIELLE (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta clearance;Affect;Age;Algorithms;Alzheimer's Disease;Amyloid beta-Protein;Animal Model;Auditory;Behavior;Brain;Brain region;Cells;Cognitive;cognitive function;Communication;Complex;Data;density;design;Detection;Disease;Disease Progression;Early identification;Early treatment;Environment;Exposure to;Functional disorder;Functional impairment;Goals;Head;Hippocampus;Human;human model;Impaired cognition;Impairment;improved;Individual;information processing;insight;Knowledge;Learning;Light;Location;member;Memory;memory encoding;Memory impairment;memory retrieval;mouse model;multisensory;Mus;neural;Neurobehavioral Manifestations;Neurobiology;Neurofibrillary Tangles;Neurons;Neurophysiology - biologic function;Parietal;Parietal Lobe;Pathology;Pattern;Photic Stimulation;Physiologic pulse;Poisson Distribution;prevent;Process;Research;Research Project Grants;Rodent;Rodent Diseases;Rodent Model;Sleep;Societies;Symptoms;System;tau aggregation;tau Proteins;Testing;Transgenic Mice;Translations;treatment strategy;Visual;Wakefulness;way finding;Work

PROJECT_TITLE: Decoding Hippocampal-Parietal contributions to spatial navigation in a mouse modeling Tau and AB aggregation features of Alzheimer's Disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Each year, problems related to alcohol and drug consumption, abuse, and dependence cause 88,000 deaths and cost over $249 billion in the United States. Scientific research into the causes and prevention of alcohol- and other drug-related problems across the lifespan, as well as treatment advances for individuals diagnosed with alcohol dependence is urgently needed to address these public health concerns. The purpose of this training grant application is to train and equip the next generation of scientific researchers who are committed to understanding and ameliorating the costs, causes, and consequences of alcohol- and drug-related problems.

PI_NAMEs: BLOW, FREDERIC C (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TITLE: Multidisciplinary Alcoholism Research Training Program


NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Chronic Kidney Disease (CKD) is characterized by increased skeletal and extra-skeletal production of fibroblast growth factor (FGF)-23 that is associated with cardiovascular mortality. Inflammation, iron deficiency (ID) and reduced expression of miR-122 stimulate FGF23 production. This project proposes to test the impact of inflammation and ID on extra-skeletal sources of FGF23, and the role of miR-122 on the post-translational modifications of FGF23 in CKD, thus providing potential therapeutic targets for individuals with CKD.

PI_NAMEs: DAVID, NICOLAE VALENTIN (contact)

PROJECT_TERMS: Acute;Address;adverse outcome;antagonist;Blood Circulation;bone;bone cell;Brucella abortus;Cardiac;Cardiovascular system;Cell Line;Cell Lineage;Cell Separation;Cells;Cessation of life;Chronic;Chronic Kidney Failure;Circulation;Coupled;Data;dentin matrix protein 1;design;Development;Diet;Dietary Iron;Disease Progression;Enzymes;Erythroid;Erythroid Cells;fibroblast growth factor 23;Flow Cytometry;GALNT3 gene;Genetic;Genetic Transcription;Goals;Health;Heart Diseases;Hormones;Impairment;improved;improved outcome;Individual;Inflammation;Inflammatory;inhibitor;Injections;innovation;Innovative Therapy;inorganic phosphate;Interleukin-1 beta;Iron;iron deficiency;Kidney;Lead;Liver;Macrophage;Measures;Metabolism;MicroRNAs;mimetics;Minerals;Modeling;Morphology;mortality;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteocytes;Patients;Peptides;pharmacologic;Post-Translational Protein Processing;Post-Translational Regulation;premature;prevent;Production;Productivity;Regulation;Resources;response;Role;Serum;skeletal;skills;Source;Stimulus;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Transfection;Universities;Untranslated Regions;Wild Type Mouse

PROJECT_TITLE: Regulation of FGF23 in Chronic Kidney Disease (CKD) by iron and inflammation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Project Narrative: The positioning and architecture of a stem cell niche is crucial to the niche's ability to maintain stem cells and thus, to maintain appropriate tissue renewal during injury or aging. The mechanisms by which niches are assembled, however, remain poorly characterized. Using a powerful genetic model, this proposal will investigate the molecular mechanisms required to assemble a stem cell niche, which is required for development and maintenance of functional biological tissues.

PI_NAMEs: ANLLO, LAUREN M. (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adhesions;Aging;Anterior;Architecture;Biological;Biological Models;Biology;Biomedical Research;cancer cell;cell behavior;cell motility;Cell Polarity;cell replacement therapy;Cells;Coupled;Cues;Curiosities;Cytoskeleton;Data;depolymerization;Development;Drosophila genus;Embryo;Ensure;Environment;experience;experimental study;F-Actin;Fibroblast Growth Factor;Funding;Generations;Genetic;genetic manipulation;Genetic Models;Gonadal structure;high resolution imaging;Homeostasis;Image;Image Analysis;in vivo;Infrastructure;Injury;islet;Islet Cell;Knowledge;Laboratory Study;Link;live cell imaging;Maintenance;male;Mediating;Men's Role;migration;minority student;Molecular;Morphogenesis;Movement;Muscle;Natural regeneration;novel;optogenetics;Organ;Organogenesis;Orthologous Gene;permissiveness;Positioning Attribute;Protocols documentation;Publishing;Regulation;Research;Resolution;response;Role;Rural;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell model;stem cell niche;stem cell replacement;stem cells;Students;success;Testing;Testis;Time;tissue regeneration;Tissues;tool;Training;transcription factor;tumor microenvironment;undergraduate student;Universities;Visceral;Work

PROJECT_TITLE: Mechanisms required to compartmentalize the stem cell niche during organogenesis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]