FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Rapid and accurate detection, identification, and characterization of invasive bloodstream infections is one of the most urgent unmet clinical needs today, where timely initiation of the appropriate antimicrobial is one of the key determinants of patient outcome. The current standard of care is too slow, is known to miss certain infections and cannot be used to track progression of the infection. In this program, HelixBind will leverage its RaPID platform and RaPID/BSI to develop the first diagnostic test capable of not only identifying these infections direct from blood, but also assessing the microbial load while monitoring progress towards clearance in response to the antimicrobial intervention. The information provided would enable the clinician to personalize the antimicrobial for optimal outcomes, ensure progress is being made towards recovery, while improving antimicrobial stewardship.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;antimicrobial;Antimicrobial Resistance;Assessment tool;Biological;Biological Assay;Blinded;Blood;Blood specimen;Breakthrough device;Budgets;Caring;Cessation of life;Clinical;Clinical Research;clinical research site;Collaborations;combat;Combined Modality Therapy;commercialization;cost;design;Detection;Development;Diagnostic;diagnostic strategy;Diagnostic tests;diagnostic tool;Dose;Early Diagnosis;Early treatment;Ensure;Exhibits;follow-up;Hospitalization;Hospitals;Hour;improved;in vivo;Infection;innovation;interest;Intervention;Lead;Leadership;Measurement;Measures;Medical center;member;Methods;microbial;Molecular Diagnostic Testing;Monitor;National Institute of Allergy and Infectious Disease;novel diagnostics;optimal treatments;Outcome;pathogen;pathogenic bacteria;pathogenic fungus;patient population;Patient-Focused Outcomes;Patients;Performance;Preparation;programs;Recovery;Research Design;Resistance;response;Sampling;Sepsis;Septicemia;Severities;Source;Specificity;Specimen;standard of care;Stress Tests;success;System;systemic inflammatory response;Techniques;Technology;Test Result;Testing;Time;timeline;Treatment Effectiveness;Validation;validation studies;Viral;Viral Load result;Whole Blood;Work

PROJECT_TITLE: Diagnostic tool for assessment and tracking of microbial load in bloodstream infections


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CLEMENT J. ZABLOCKI VA MEDICAL CENTER

ORG_STATE: WI

PHR: This project is of foremost relevance to Veterans and service members that have suffered from a concussion or traumatic brain injury (TBI), but has the potential to help people afflicted with heart disease as well. The heart and the brain do not function properly after TBI. In a healthy heart, there is a normal variation in the timing between beats, even at rest, which is controlled unconsciously by the brain. This variability in heart rate is altered by TBI and is associated with decreased quality of life, increased health care utilization, and premature death. The proposed studies will further our understanding of how TBI changes the brain processes controlling heart rate at rest and in response to stress with the goal of identifying new therapeutic targets or identify new tests (biomarkers) that provide accurate expectations of recovery from a trauma (prognostication), which could transform the way Veterans are evaluated for “return to service.” The long-term objective is to develop treatments that will improve medical outcomes for Veterans with TBI and heart disease.

PI_NAMEs: ROBERTS, CHRISTOPHER JON (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;Amygdaloid structure;Animal Model;antagonist;Anxiety;Anxiety Disorders;Arrhythmia;Autonomic nervous system;awake;Award;Baroreflex;Behavior;Behavior Control;Behavioral;Biological Markers;Biomedical Engineering;Blood Pressure;Blood Pressure Monitors;Body Weight;Brain;Brain Concussion;Brain region;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;career development;Cessation of life;Chronic;Chronic disability;combat;Compensation;conditioned fear;Cues;Data;Department of Defense;designer receptors exclusively activated by designer drugs;detection sensitivity;Development;Disease;Dysautonomias;Elements;expectation;Exposure to;Extinction;falls;Female;field study;Foundations;Fright;Functional disorder;Future;GABA Agonists;gamma-Aminobutyric Acid;genetic manipulation;Goals;Health;health care service utilization;Heart;Heart Diseases;Heart Rate;heart rate variability;Homeostasis;Human;Impairment;Implant;improved;injured;Injury;innovation;interest;Knowledge;Life Expectancy;Ligands;Link;male;Measures;Mediating;Medical;Mental Health;Methodology;Microinjections;Modeling;Mood Disorders;Morbidity - disease rate;mortality;Nature;Nervous System Physiology;Neuroanatomy;Neurological outcome;neuronal circuitry;Neurons;neurophysiology;new therapeutic target;Nitroprusside;non-invasive monitor;novel;Operative Surgical Procedures;Outcome;Pathogenicity;Pathology;Persons;pharmacologic;Phenylephrine;Post-Traumatic Stress Disorders;premature;pressure;Process;Prognostic Marker;prognostication;Quality of life;Rattus;Recovery;Regulation;Rehabilitation therapy;response;Rest;Rodent;Role;service member;Services;Site;Solid;Stress;stressor;Structure;Survivors;Technology;Telemetry;Testing;Thallium Myocardial Perfusion Imaging Stress Test;Therapeutic;therapeutic target;Time;Training;translational potential;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment strategy;Unconscious State;Variant;Vehicle crash;Veterans

PROJECT_TITLE: Cardiovascular dysfunction following Traumatic Brain Injury


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Project Narrative - Relevance to Public Health Statement:  Currently there are no effective drugs that prevent the death of nerve cells associated with age- dependent neurodegenerative conditions such as Alzheimer's disease. These diseases occur in the context of aging, yet most drug discovery projects use an approach that does not account for aging as a key aspect of the disease pathology. Since old age is the greatest risk factor for Alzheimer's disease, in this proposal we are using a highly innovative approach for drug discovery by identifying Alzheimer's disease drug candidates in screening assays that represent multiple, old age-associated toxicities that have not been explored by the pharmaceutical industry, leading to new drug candidates for old-age associated neurodegenerative diseases.

PI_NAMEs: MAHER, PAMELA ANNE (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acceleration;Address;Affinity;Age;age related;age related neurodegeneration;age-related disease;Aging;aging brain;aging mechanism;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Animals;anti aging;Bioinformatics;Biological Assay;Biology;Brain;Brain Pathology;Caenorhabditis elegans;Caloric Restriction;Cell Death;Cells;Chemicals;Chemistry;Clinic;Clinical Trials;Cognition;CRISPR screen;Dementia;Disease;drug candidate;drug discovery;Drug Industry;drug repurposing;Drug Screening;Drug Targeting;Drug usage;effective intervention;effective therapy;extend lifespan;familial Alzheimer disease;fly;Gene Expression;Genes;Genetic Transcription;geroprotector;Geroscience;Goals;Hippocampus;Human;human old age (65+);improved;innovation;Investigational Drugs;Laboratories;Libraries;life span;Longevity;Mammals;man;Memory impairment;Metabolism;metabolomics;Metformin;model organism;Modeling;Molecular;Molecular Target;mouse model;Mus;Mutation;Names;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;neurotoxicity;novel;novel strategies;novel therapeutics;overexpression;Pathology;Pathway Analysis;Pathway interactions;Penetration;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Plasma;Population;Precipitation;prevent;protective factors;Proteins;Proteomics;Protocols documentation;Public Health;Research Institute;Resources;Robotics;Safety;Scientist;screening;Signal Pathway;Sirolimus;small molecule;Source;tau Proteins;Technology;Testing;Time;Toxic effect;transcriptome sequencing;Treatment Efficacy;Validation;validation studies;Wild Type Mouse;Work

PROJECT_TITLE: Using geroscience to understand and treat Alzheimer's disease


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE PASC, or the post-acute sequalae of SARS-CoV-2 infection, will impact the individual health of millions of Americans over the next decade, yet few studies have examined the potential long-term effects of SARS-CoV- 2 on gastrointestinal outcomes (PASC-GI) such as Irritable Bowel Syndrome (IBS). This research aims to determine the burden the SARS-CoV-2 infection has for both incident and pre-existing IBS and other PASC-GI outcomes. Using a multi-omics approach this study will also investigate the underlying mechanistic pathways critical to ascertain, diagnose, and ultimately treat these disabling PASC-GI conditions.

PI_NAMEs: POGREBA-BROWN, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;acute infection;Adult;Affect;Age;American;Arizona;associated symptom;Bacterial Infections;Biological;Biological Markers;Blood specimen;Caregivers;Chronic;cohort;comorbidity;COVID-19 burden;COVID-19 patient;Critical Pathways;Data;Death Rate;Development;Diagnosis;Diagnostic;Diarrhea;Disabling;Disabling condition;Disease Progression;disorders of gut-brain interaction;Enrollment;Enteric Nervous System;Ethnic Origin;experience;fecal microbiome;Functional Gastrointestinal Disorders;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;gastrointestinal symptom;Gender;gut inflammation;gut microbiome;Health;Health Personnel;high dimensionality;host microbiome;Immune response;Immunoglobulin A;Immunoglobulin G;Impairment;Incidence;Individual;Infection;infection rate;Infrastructure;Investigation;Irritable Bowel Syndrome;Link;Long COVID;long term consequences of COVID-19;Long-Term Effects;Longitudinal cohort study;longitudinal, prospective study;Metagenomics;microbiome composition;Morbidity - disease rate;Morphology;multiple omics;Nausea;novel;novel marker;Outcome;pandemic disease;pandemic impact;Participant;pathogen;Pathologic;Patients;Persons;Phenotype;Physiological;Play;Population;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;protein biomarkers;Proteomics;Protozoan Infections;psychologic;Quality of life;Questionnaires;Recording of previous events;Reporting;Research;Risk;Risk Assessment;Risk Factors;Role;Rome;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 positive;Serum;Serum Proteins;Severities;Shotguns;stool sample;Stress;Symptoms;Testing;Time;Virus Diseases;Vomiting

PROJECT_TITLE: Determining the Incidence, Risk Factors and Biological Drivers of Irritable Bowel Syndrome (IBS) as Part of the Constellation of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Outcomes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Corticostriatal circuits are involved in a large number of neurological and neuropsychiatric brain disorders that are also associated with impaired decision making and reduced cognitive flexibility. Impairments to decision making and reduced cognitive flexibility can cause severely debilitating negative impacts on life. An improved understanding of the connection between corticostriatal circuits and these impairments will be useful for developing new mental health treatments and avoiding side effects of treatments targeted to these brain circuits.

PI_NAMEs: HANKS, TIMOTHY D. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Corticostriatal contributions to evidence evaluation and decision selection

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Lymphatic Research;Regenerative Medicine;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Triple-negative breast cancer (TNBC), characterized by poor prognostic outcomes, forms solid tumors with high interstitial fluid pressure (IFP) in the tumor microenvironment, where the high IFP compromises cancer immunotherapies by limiting T cell infiltration in the tumors. Given that lymphatic vessels are structurally and functionally impaired in TNBC tumors, which can increase tumor IFP and dampen anti-tumor immunity, this project will decipher the mechanisms of alterations of lymphatic structure and drainage in TNBC and examine new strategies to promote TNBC immunotherapies by normalizing tumor lymphatic function.

PI_NAMEs: LEE, ESAK  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Affect;angiogenesis;Binding;Biological Models;Biology;Biomedical Engineering;Blood;Blood Vessels;Boston;Brain;Breast;Breast Cancer Cell;cancer cell;Cancer Etiology;cancer immunotherapy;CAR T cell therapy;Cell Communication;cell motility;Cells;Coculture Techniques;Collaborations;Complex;cytokine;Dendritic Cells;Drainage procedure;drug candidate;Endothelial Cells;Environment;Epidermal Growth Factor Receptor;Estrogen Receptors;Extracellular Matrix;Functional impairment;Goals;Human;Immune;immune cell infiltrate;Immune Evasion;Immune System Diseases;Immunologist;Immunotherapy;Impairment;In Vitro;in vivo;Infiltration;inhibitor;Intercellular Fluid;Intercellular Junctions;interstitial;Knockout Mice;lacteal;Lead;Lymphangiogenesis;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic Invasion;Lymphatic System;lymphatic vessel;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary epithelium;Mammary Neoplasms;Matrix Metalloproteinases;Mediating;Medicine;Meningeal lymphatic system;Metastatic Neoplasm to Lymph Nodes;Modeling;Morphogenesis;Mucin 1 protein;Neoplasms in Vascular Tissue;Oncologist;Organ;Outcome;Pediatric Hospitals;Physiological;pressure;Progesterone Receptors;prognostic;Protein Kinase;recruit;Regulation;Reporting;Research Personnel;rho;ROCK1 gene;Role;screening;Small Intestines;Solid;Solid Neoplasm;Stress;Structure;synergism;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted treatment;three-dimensional modeling;Tissue Engineering;Tissues;tool;trafficking;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Vascular Endothelial Growth Factor C;Vascular System;Women's mortality

PROJECT_TITLE: Tissue-Engineered Models of Lymphatic Drainage in Breast Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE The project will test the hypothesis that PTSD is associated with changes in gray matter myelin content which affect functional circuits. The project involves the study of postmortem brain tissue from the National Center for PTSD Brain Bank as well as living subjects studied with brain imaging.

PI_NAMEs: HUBER, BERTRAND R;NEYLAN, THOMAS C (contact);WOODWARD, STEVEN H.

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Acceleration;Affect;Amygdaloid structure;Animal Model;Anterior;Autopsy;Axon;Brain;brain abnormalities;Brain imaging;Brain region;brain tissue;Caliber;case control;cingulate cortex;Data;density;design;Development;Dorsal;Exhibits;experience;Fright;Functional impairment;gray matter;Hippocampus;Human;Image;in vivo;Insula of Reil;Intervention;Mental disorders;Methods;Modeling;Myelin;Myelin Sheath;myelination;Neural Conduction;Neurites;neuroimaging;Neuronal Plasticity;neuropathology;novel;Post-Traumatic Stress Disorders;remyelination;response;Rest;Structure;Study Subject;Synapses;Syndrome;System;Testing;Therapeutic Agents;Thick;Water;white matter

PROJECT_TITLE: Investigating Fear System Myelination in PTSD Using In Vivo and Post Mortem Data

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The UAB NORC facilitates research that can help reduce obesity and obesity-related chronic disease in the population. We are leaders in precision approaches to individualizing optimum diets and lifestyle intervention approaches. We are also a leading place for training the next generation of nutrition and obesity research and leaders.

PI_NAMEs: HILL, JAMES O (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Acceleration;Address;Administrator;Alabama;Animal Model;Area;Award;base;Basic Science;Behavior;Behavioral Sciences;Biology;Body Weight decreased;Chronic Disease;Clinical;clinical center;Clinical Research;Collaborations;Communities;complex data;Data Analyses;Deep South;Development;Dietary Intervention;Direct Costs;disability;Disabled Persons;Doctor of Philosophy;Ensure;Environment;Etiology;Exercise;experience;Extramural Activities;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Imagination;Infrastructure;Institution;interdisciplinary collaboration;interest;Laboratories;Leadership;Letters;lifestyle intervention;Maintenance;member;Metabolic;Metabolic Diseases;Metabolism;multidisciplinary;Names;next generation;nutrition;Nutritional Science;Nutritional Study;Obesity;Paper;Pathway interactions;Peer Review;personalized approach;Population;Positioning Attribute;Postdoctoral Fellow;precision nutrition;Prevention;Productivity;programs;Publications;Publishing;recruit;Reporting;Research;Research Design;Research Personnel;Research Support;Science;Scientist;Senior Scientist;Series;Services;success;Talents;Training;Translating;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Universities;weight maintenance

PROJECT_TITLE: UAB Nutrition Obesity Research Center (NORC)


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Project Narrative Pioneer factors are mutated in various tissues and in immune cell pathways, thus underscoring their importance in development and disease. This project will investigate how pioneer factors mediate cellular reprogramming, specifically by probing the mechanism(s) behind their chromatin opening activity and learning how they recognize binding sites within closed chromatin. These studies will shed light on understanding the function of pioneer factor GATA3 in breast cancer cells.

PI_NAMEs: COOPER, MIKHALA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Architecture;Binding;Binding Sites;Biology;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Cancer Biology;Cell Reprogramming;Cells;ChIP-seq;Chromatin;chromatin modification;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;Data;Development;Disease;DNA;DNA Repair;Doxycycline;Enhancers;Enzymes;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;ESR1 gene;Essential Genes;Eukaryotic Cell;experimental study;GATA3 gene;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genome;Genomic DNA;Goals;Histones;Homeostasis;Human Genome;Immune;Immunoprecipitation;innovation;insight;Interruption;Knowledge;Learning;Maintenance;Malignant Breast Neoplasm;mammary epithelium;Mammary Neoplasms;Mass Spectrum Analysis;MDA MB 231;Measures;Mediating;Methods;Molecular;Mutate;Mutation;next generation sequencing;novel;Nucleosomes;Pathway interactions;Phenotype;Poly(ADP-ribose) Polymerases;prevent;Property;Proteins;Research;Role;Site;Specificity;System;Testing;Tissues;transcription factor;Transcriptional Activation;Work

PROJECT_TITLE: Function of GATA3-PARP1 complex in breast cancer during GATA3-mediated cellular reprogramming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TERMS: Address;Advisory Committees;Advocate;Automobile Driving;base;Basic Science;career development;Clinic;Clinical;Clinical Research;Collaborations;Communication;Communities;Core Facility;Creativeness;Development;Elements;Ensure;Environment;equity, diversity, and inclusion;experience;Faculty;Feedback;Fostering;Fund Raising;Funding;Future;Goals;graduate student;Grant;Growth;Health;High School Student;Human;improved;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Knowledge;Link;member;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;nutrition;Obesity;Personal Satisfaction;Positioning Attribute;Productivity;programs;recruit;Research;Research Personnel;Research Training;Resources;Science;Scientist;Strategic vision;success;Training;Training and Education;Translating;Translational Research;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Update;web site;Work

PROJECT_TITLE: UAB NORC Core A - Administrative Core


PI_NAMEs: GOWER, BARBARA A (contact)

PROJECT_TERMS: Accelerometer;Adult;Aerobic Exercise;Air;Blood Pressure;Body Composition;body density;Body fat;Body measure procedure;Body Regions;Body Water;Budgets;Child;Clinical Nutrition;Communities;cost effective;Data;Development;doubly-labeled water;Dual-Energy X-Ray Absorptiometry;Education;Elasticity;Energy Metabolism;Evolution;Exercise;Exercise Test;Faculty;Fatty acid glycerol esters;Frequencies;Funding;Hour;Human body;Human Resources;Hypoxia;Indirect Calorimetry;Infant;Infrastructure;insight;Institution;Instruction;instrument;instrumentation;Interdisciplinary Study;Isotopes;Magnetic Resonance Imaging;Measurement;Measures;Metabolism;Methodology;Methods;Modeling;new technology;nutrition;Obesity;Online Systems;oxidation;Oxygen Consumption;Performance;Philosophy;Physical activity;Pilot Projects;Plethysmography;Population;portability;Protocols documentation;Quality Control;Research;Research Personnel;Research Project Grants;response;Rest;Schedule;Services;Sleep;Students;System;Technology;Testing;theories;Time;total energy expenditure;Training;ultrasound;Universities;X-Ray Computed Tomography

PROJECT_TITLE: UAB NORC Core B: Metabolism


NIH_SPENDING_CATS: Biomedical Imaging;Nutrition;Obesity

PI_NAMEs: SMITH, DANIEL L (contact)

PROJECT_TERMS: Affect;Animal Experimentation;Animal Experiments;Animal Model;Animal Nutrition;Animals;Area;Biological Factors;biological research;Body Composition;Body Temperature;Calorimetry;Characteristics;Chemicals;Communities;comparative;cost effectiveness;cost efficient;Development;Diet;Diet and Nutrition;Dual-Energy X-Ray Absorptiometry;Eating;energy balance;Energy Metabolism;Equipment;Exercise;experimental study;Formulation;Functional disorder;Genetic;Goals;Health;Human;human disease;In Vitro;in vivo;Indirect Calorimetry;Individual;innovation;instrumentation;Intrinsic factor;Knowledge;Magnetic Resonance;Measures;metabolic rate;Methodology;Methods;microCT;Miniaturization;Mission;Molecular;monitoring device;nutrition;Obesity;Organism;Outcome;Output;Pharmaceutical Preparations;Phenotype;Physiology;Preparation;Production;Quality Control;Reference Standards;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resources;Rodent;Rodent Model;Science;Scientific Inquiry;Services;Strategic Planning;tool;Training;United States National Institutes of Health;Work;working group;Zebrafish

PROJECT_TITLE: UAB NORC Core C: Animal Models Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE Minorities with MS face increased disease severity in comparison to whites with MS, possibly due to the differences in the immune responses between the populations, making it important to understand the contribution of the immune response to disease severity in Minorities with MS. We have observed that plasmablasts are expanded in Minorities with MS in comparison to whites with MS. In this project, we will test whether these expanded plasmablasts make antibody that binds to neurons and makes disease worse using a mouse model.

PI_NAMEs: AMEZCUA, LILYANA ;MONSON, NANCY L (contact);VARTANIAN, TIMOTHY

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;advanced disease;African American;African American population;Antibodies;Antigen Targeting;Atrophic;B-Lymphocytes;Binding;Biological;Caring;Cells;Clinical;clinical investigation;cognitive disability;cohort;Data;Demyelinations;diagnostic tool;disability;Disease;Disease Progression;Event;experience;Face;Flow Cytometry;Frequencies;Future;Genes;Genetic;Goals;gray matter;Health;Hispanic Populations;Immune;Immune response;Immunoglobulin G;Immunologics;Immunology;in vivo Model;Incidence;indexing;Inflammation;Inflammatory;insight;Knowledge;Latinx;Mediating;Minority;Minority Groups;minority patient;minority subjects;Molecular Genetics;mouse model;Multiple Sclerosis;multiple sclerosis patient;neuroimmunology;Neurologic Deficit;Neurons;neurotoxicity;next generation sequencing;novel;Oligoclonal Bands;Outcome;patient response;Patients;physically handicapped;Plasmablast;Population;Positioning Attribute;predictive tools;Predisposition;Prevalence;Prevention;Production;Recovery;Refractory;Relapse;Reporting;Risk;Role;Severity of illness;Technology;Testing;tool;treatment response

PROJECT_TITLE: Immunology of advancing disease among minorities with Multiple Sclerosis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention

PI_NAMEs: DUTTON, GARETH R (contact)

PROJECT_TERMS: Adherence;Applied Research;arm;Bayesian Modeling;Behavior;Behavior assessment;behavior change;behavior observation;Behavior Therapy;Behavioral;behavioral construct;behavioral outcome;Behavioral Sciences;behavioral study;Biometry;Case Report Form;Clinical;Clinical Nutrition;Clinical Research;Clinical Trials Design;Collaborations;Collection;compliance behavior;Computerized Medical Record;Consultations;Coupled;Data;Data Analyses;Data Analytics;Data Collection;data management;data mining;Data Sources;design;Development;Dietary Intervention;Dose;electronic data;Electronics;ethnic minority;Etiology;Evaluation;Evolution;Focus Groups;Fostering;Funding;Geographic Locations;Grant;health disparity;improved;innovation;insight;Intervention;Interview;Knowledge;Machine Learning;member;Methods;Modality;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;obesity risk;obesity treatment;Observational Study;Pattern;Population;pragmatic trial;Procedures;Productivity;Qualitative Methods;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;Registries;Research;Research Design;Research Personnel;Resources;response;Sample Size;Sequential Multiple Assignment Randomized Trial;Services;Statistical Data Interpretation;Statistical Methods;Strategic Planning;Surveys;System;Techniques;Technology;Testing;Text;Text Messaging;theories;Therapeutic;therapy design;therapy development;trial design;United States National Institutes of Health;Voice;wearable data;wearable device;Weight maintenance regimen

PROJECT_TITLE: UAB NORC Core D: Behavioral Science and Analytics


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed studies seek to understand whether a small number of fetal cells transferred to the mother during pregnancy (fetal microchimerism) is associated with later-life cardiovascular disease (CVD) in women with a history of preeclampsia. In parallel, we will expand the usability of an advanced next-generation sequencing approach for improved microchimerism evaluation. This work will modernize the techniques for microchimerism studies while investigating a possible contributor to CVD in a unique cohort of women with the potential to identify novel diagnostics and therapeutic interventions to limit the burden of disease.

PI_NAMEs: SHREE, RAJ  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adult;Affect;Atherosclerosis;Autoimmune Diseases;biobank;Biological;Biological Assay;Biological Phenomena;Blood specimen;Body System;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Cell Line;Cells;Clinic;cohort;Data;Detection;detection method;Development;Diagnosis;Discipline of obstetrics;Disease;disease phenotype;endothelial dysfunction;epidemiologic data;epidemiology study;Evaluation;Event;experience;Family;fetal;Fetus;fetus cell;Foundations;Functional disorder;Genetic Polymorphism;Genotype;Goals;Hypertension;Immune response;improved;Inflammatory;Injury;Investigation;Laboratories;late life;Life;Link;Malignant Neoplasms;maternal morbidity;Maternal Mortality;Measures;men;Metabolic;Methodology;Microchimerism;Microvascular Dysfunction;Modernization;Molecular;Mothers;next generation sequencing;novel;novel diagnostics;novel strategies;novel therapeutic intervention;offspring;Participant;Pathway interactions;peripartum cardiomyopathy;peripheral blood;Physiology;placental transfer;Play;Population;Pre-Eclampsia;Pregnancy;premature;Prevalence;Process;programs;prospective;Proteinuria;Recording of previous events;reproductive;Reproductive Health;Research;Research Design;Risk;Risk Factors;risk sharing;Role;Sampling;Scientist;sexual dimorphism;Specimen;Stroke;Techniques;technological innovation;Technology;Testing;Time;tool;translational physician;usability;Vascular Diseases;Woman;Women's cohort;Women's mortality;Work

PROJECT_TITLE: Cardiovascular disease, preeclampsia, and microchimerism

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: BARNES, STEPHEN  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Award;career;Categories;Characteristics;Child;clinical center;Clinical Sciences;Collaborations;Communities;community center;Core Facility;design;Development;Disease;elderly nutrition;Electronic Mail;Electronics;Eligibility Determination;Ensure;Environment;environmental enrichment for laboratory animals;Event;Extramural Activities;falls;Family;feasibility testing;Fostering;Funding;Funding Opportunities;Goals;Grant;Growth;Health;high risk;Human;improved;Individual;innovation;insight;Institution;interest;Journals;Leadership;Longevity;Maintenance;member;Mentors;Monitor;Names;Newspapers;novel;novel strategies;nutrition;Nutritional Study;Obesity;Peer Review;Positioning Attribute;Postdoctoral Fellow;Prevention;Prevention strategy;Process;programs;Publications;Quality of life;Records;Research;Research Personnel;Research Project Grants;Scheme;Schools;Science;success;Testing;Translational Research;United States National Institutes of Health;Universities;web site;Writing

PROJECT_TITLE: UAB NORC Pilot and Feasibility Program


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Overall Project Narrative The COBRE for Stem Cells and Aging provides core services for full evaluation of cellular abnormalities in diseases of stem cells and aging, forming a basis for therapeutic approaches. The program also supports junior faculty with mentoring activities and pilot project support.

PI_NAMEs: QUESENBERRY, PETER J. (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Aging;aging related;aging related disease;Area;Basic Science;Biological;Biology of Aging;Biotechnology;Caliber;Cell Aging;Centers of Research Excellence;Cessation of life;Clinical;Collaborations;Communities;Complex;Development;Disease;Equipment;Evaluation;extracellular;extracellular vesicles;Extramural Activities;Faculty;field study;Flow Cytometry;Funding;Goals;Grant;Growth;Individual;insight;Leadership;Lentivirus;Mentors;Mentorship;multidisciplinary;novel therapeutic intervention;Performance;Phase;Pilot Projects;programs;Research;Research Infrastructure;Research Personnel;restoration;Rhode Island;Scientist;Services;Side;stem cell biology;stem cells;Structure;success;Therapeutic;Tissues;Translational Research;United States National Institutes of Health;Universities;Viral;Vision

PROJECT_TITLE: Stem Cells and Aging


ORG_DEPT: GENETICS

PHR: Project Narrative Transcription factor (TF) networks in the heart, lungs and blood (H LB) ensure faithful development and maintenance of cellular homeostasis in these organ systems, with dysregulation of HLB-specific TFs leading to numerous disorders. Due to their central role in biology, methods to study how TFs bind to the genome are well developed, yet we lack a methodological framework for identifying genetic factors that regulate TFs at the protein level. This proposal aims to address this shortcoming by developing a novel framework for the discovery of genes that control HLB-specific TF protein abundances.

PI_NAMEs: SUITER, CHASE CAMERON (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Ablation;Address;Affinity Chromatography;Amino Acid Motifs;analytical tool;Bar Codes;Binding;Biological;Biological Assay;Biology;Blood;Body System;Bone Marrow;Cell Physiology;cell type;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Complex;Computing Methodologies;Coupled;Data;Databases;Development;Disease;DNA;DNA Binding;Engineering;Ensure;Equilibrium;Erythropoietin;Failure;Fellowship;Flow Cytometry;gene discovery;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Goals;Guide RNA;Heart;Heart Diseases;Hematological Disease;Homeostasis;Human;human disease;Human Genome;Hypoxia;improved;Individual;insight;interest;Investigation;Knowledge;Libraries;Ligase;Link;Lung;Lung Diseases;lymph nodes;Maintenance;Maps;Mass Spectrum Analysis;Measures;Mediating;Methodology;Methods;Molecular;multicatalytic endopeptidase complex;Mutate;new therapeutic target;next generation;next generation sequencing;novel;novel strategies;Onset of illness;Organism;Output;overexpression;Oxygen;Pathologic;Patients;Peptides;Phenotype;Play;Post-Translational Regulation;preempt;prevent;Production;programs;protein aminoacid sequence;protein degradation;protein protein interaction;Proteins;Proteolysis;proteostasis;Records;Red Blood Cell Count;red fluorescent protein;Regulation;Reporter;Research;response;Role;Series;Specificity;statistics;stem;Substrate Interaction;System;Testing;Therapeutic Intervention;therapeutic target;Tissues;Training;Transcript;transcription factor;Transcriptional Regulation;Translating;Ubiquitin;ubiquitin ligase;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;Universities;Washington

PROJECT_TITLE: Comprehensive identification of E3 ubiquitin ligases that degrade heart, lung, and blood-relevant transcription factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Aging;Area;Basic Science;Biology;Biology of Aging;Biometry;Centers of Research Excellence;clinical development;Clinical Protocols;clinically relevant;Development;Disease;Education;Educational workshop;extracellular vesicles;Flow Cytometry;Foundations;Grant;Individual;innovation;Institution;Lead;Leadership;Lentivirus;member;novel strategies;Participant;Performance;Phase;programs;Research;Research Personnel;RNA;skills;stem cells;success;Technology Transfer;Therapeutic;Translating;Translational Research;Vision

PROJECT_TITLE: Administrative Core COBRE Phase III Stem Cells and Aging


PROJECT_TERMS: Academia;Address;Alabama;Applied Research;Area;base;Basic Science;Chronic Disease;Clinic;Clinical Research;Collaborations;Communities;Country;Creativeness;Deep South;Education;Education and Outreach;Educational workshop;Ensure;Environment;Evaluation;Faculty;Fostering;Funding;Funding Opportunities;Future;Generations;Health;High School Student;Individual;Institution;Knowledge;Laboratories;member;mindfulness;Mission;multidisciplinary;next generation;nutrition;Nutritional Science;Nutritional Study;Obesity;Participant;Postdoctoral Fellow;pre-doctoral;Prevention;programs;prospective;Research;Research Personnel;Research Project Grants;Research Training;Role;Scientist;Series;success;symposium;Training;Training Programs;Translating;Translational Research;Underrepresented Populations;webinar;Work

PROJECT_TITLE: UAB NORC Enrichment Program


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: Astrocytes provide essential support for synapse development, plasticity, and signaling; yet little is known about the basic cellular and molecular mechanisms that govern this function. This proposal aims to investigate the lysosome as a critical signaling organelle at astrocyte-neuron synapses and define mechanisms of lysosome trafficking in astrocytes. Knowledge from this study will enlighten how astrocyte dysfunction may contribute to synaptic deficiencies in neurodevelopmental and neurodegenerative disorders.

PI_NAMEs: COUGHLAN, MAEVE LOUISE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Actins;Affect;Astrocytes;Calcium;Calcium Spikes;Cell surface;Cells;Chemicals;Coculture Techniques;Confocal Microscopy;Cytoskeletal Modeling;Cytoskeleton;Data;Dendrites;density;Detection;detection assay;Development;Dominant-Negative Mutation;early onset;Exhibits;Exocytosis;Extracellular Matrix;F-Actin;Functional disorder;glutamatergic signaling;Glutamates;Goals;Hydrolase;Immobilization;Impairment;in vivo;Knowledge;Label;live cell imaging;Lysosomes;Measures;media use;Mediating;Metabolic;Methodology;Microfilaments;Microtubules;Molecular;molecular marker;Morphology;Motility;Motor;Mus;Mutation;MYO5A gene;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuron component;Neurons;Organelles;overexpression;Pathology;Pathway interactions;Peptide Hydrolases;pharmacologic;Play;Positioning Attribute;Process;recruit;Regulation;Resolution;response;Role;Signal Transduction;Source;spatiotemporal;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;System;Testing;Time;trafficking;Vesicle;Work

PROJECT_TITLE: Defining the Role of Astrocytic Lysosome trafficking and Exocytosis in Regulating Synapse Maturation


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative One of the major ways that diabetes causes death in those it afflicts is by causing heart disease, while the mechanism by which diabetes drives heart disease remains largely unknown. Our recently attained data suggest a central role for gut microbiota. This proposal, which will build on this data, seeks to elucidate understanding of how diabetes causes heart disease and, moreover, develop approaches to prevent it.

PI_NAMEs: ZOU, JUN  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Antibiotics;Automobile Driving;Bacteria;bacterial community;Biological;Cardiac;Cause of Death;chronic inflammatory disease;Colon;comorbidity;Data;defined contribution;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diet;Dietary Fiber;Disease;dysbiosis;Genetic;Glucose;glycemic control;Goals;gut bacteria;gut microbiota;heart damage;heart disease risk;Heart Diseases;Heart failure;heart function;Immunologics;Impairment;improved;Incidence;Inflammation;interleukin-22;Interruption;Intestinal permeability;Intestines;Link;Mediating;microbial;microbiome;microbiota;microbiota composition;microbiota transplantation;Motility;mouse model;Mucous Membrane;Mus;Myocardial dysfunction;Nanotechnology;non-diabetic;non-genetic;novel;novel strategies;Persons;pharmacologic;prevent;Public Health;Role;Signal Pathway;technology/technique;Therapeutic;therapy development;Work

PROJECT_TITLE: Role of Diabetes Associated Intestinal Dysbiosis in cardiac disease

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Adult neurogenesis takes place in the SVZ of the lateral ventricles and the SGZ of the dentate gyrus in the hippocampus. While TGF-β signaling has been implicated in this process, the precise molecular mechanisms are not well known. This proposal will provide molecular insights for the regulatory role of TGF-β signaling in the addition of adult born neurons during different stages of adult neurogenesis.

PI_NAMEs: WARE, KIERRA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Activins;Adult;adult neurogenesis;Affect;Animal Model;Anxiety;Astrocytes;Brain;Cell Lineage;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Chronic;Cognitive;cognitive function;Data;density;dentate gyrus;Development;Embryo;Emotional;forgetting;functional outcomes;Genes;Goals;Hippocampus;Homeostasis;In Vitro;in vivo;inhibitor;insight;Knock-out;Knockout Mice;Label;lateral ventricle;learning outcome;Ligands;Maps;Mediating;Memory;Mental Depression;Microglia;migration;Migration Assay;Modeling;Molecular;Morphology;mouse model;Mus;neonatal mice;nerve stem cell;Nervous System Disorder;nestin protein;Neural Inhibition;neurite growth;neuroblast;neurodevelopment;neurogenesis;neuron development;Neurons;novel;Oncogenes;Pathway interactions;Pattern;Perinatal;pharmacologic;Phenotype;Phosphotransferases;Play;Process;Proliferating;Prosencephalon;Protocols documentation;receptor;Regulation;repaired;Reporter;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Specificity;stem cell migration;stem cell population;stem cell proliferation;Tamoxifen;Testing;TGF-beta type I receptor;Therapeutic;Time;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Vertebral column

PROJECT_TITLE: A Dual Role of Activin-like kinase 5 (ALK5)-mediated TGF Beta Signaling in Adult Neurogenesis


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: DOONER, MARK S (contact)

PROJECT_TERMS: Advisory Services;Aging;Area;Basic Science;Biomedical Research;Buffers;Cell Separation;Cells;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Communities;Core Facility;Cytometry;Data Collection;Data Storage and Retrieval;Dedications;Discipline;Experimental Designs;Flow Cytometry;Goals;Growth;Health Personnel;Hospitals;Human Resources;Inductively Coupled Plasma Mass Spectrometry;Institution;instrumentation;laser cell sorter;Lasers;life span;Longevity;Mass Spectrum Analysis;particle;Phase;Phenotype;Pilot Projects;Population;Positioning Attribute;programs;Property;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Rhode Island;Role;Services;single cell analysis;Sodium Chloride;Solid;Source;stem cells;success;Suspensions;System;Techniques;Technology;time of flight mass spectrometry;Tissues;tool;Universities

PROJECT_TITLE: Flow Cytometry Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed longitudinal research will result in the development of 3 models to predict risk of progression in ocular diseases with baseline biomechanical assessment. Progression models will include novel biomechanical parameters associated with asymmetry to predict progression in keratoconus, and scleral stiffness to predict the risk of developing diabetic retinopathy in diabetes. Biomechanical parameters will be added to the Ocular Hypertension Treatment Study risk model to augment prediction of conversion from ocular hypertension to glaucoma.

PI_NAMEs: ROBERTS, CYNTHIA J (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Age;Biological Markers;biomechanical test;Biomechanics;Clinic;Clinical;Clinical Data;Clinical Management;cohort;Cornea;crosslink;Data;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Disease Progression;Elasticity;Evaluation;Eye;Eye diseases;follow-up;Foundations;Funding;Glaucoma;Glycosylated hemoglobin A;Goals;Grant;Hyperglycemia;hypertension treatment;instrument;Keratoconus;Knowledge;Longitudinal Studies;Measures;Modeling;novel;Ocular Hypertension;Ocular Pathology;Ohio;Outcome;Panthera leo;Pathologic;Performance;Pharmaceutical Preparations;Primary Open Angle Glaucoma;Procedures;Process;progression risk;Property;Protocols documentation;Research;response;Retinal Diseases;Risk;Risk Factors;risk prediction;Sclera;Spottings;Stress;Synthetic Prostaglandins;Thick;Time;tool;Translating;translational potential;Translations;Validation;viscoelasticity;Visit

PROJECT_TITLE: Corneal Biomechanics in Ocular Disease


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Neurodevelopmental disorders – including epilepsy, intellectual disability, autism spectrum disorder, and schizophrenia – have a significant and chronic impact on the quality of life of up to 1 in 6 children in the United States. Dravet Syndrome is a neurodevelopmental disorder characterized by treatment-resistant epilepsy, intellectual disability, and autism spectrum disorder, with a known causative genetic mutation and a well- validated clinically-relevant animal model, which allows for studies of disease mechanism and development of new treatments. This proposal uses electrical recording, neuroanatomy, and state of the art imaging techniques in an experimental model system to further our understanding of the pathophysiology of Dravet Syndrome with the goal of generating targets for novel therapies for neurodevelopmental disorders.

PI_NAMEs: LIEBERGALL, SOPHIE ROSE (contact)

PROJECT_TERMS: Action Potentials;Acute;Age;Animal Model;autism spectrum disorder;autism symptoms;Axon;biocytin;Biological Models;Brain;Calcium;career;Caregivers;cell behavior;Cells;Cellular Morphology;Cerebral cortex;Child;Chronic;clinically relevant;Data;Defect;Dendrites;density;Development;Developmental Delay Disorders;Diagnosis;Disease;disease mechanisms study;DNA Sequence Alteration;dravet syndrome;Economics;effective therapy;Electrical Synapse;Electrophysiology (science);Emotional;Epilepsy;excitatory neuron;Experimental Models;experimental study;Functional disorder;Future;gamma-Aminobutyric Acid;Generations;Genes;Goals;Health;Heterozygote;Image;Imaging Techniques;Impairment;In Vitro;in vivo;in vivo calcium imaging;in vivo imaging;Induced pluripotent stem cell derived human neuron;Intellectual functioning disability;Interneurons;Locomotion;Loss of Heterozygosity;Mediating;Mediator;Molecular;Morphology;mouse model;multiphoton imaging;Mus;Neocortex;neocortical;Nervous System Disorder;Neuroanatomy;Neurodevelopmental Disorder;Neurons;neurotrophic factor;new therapeutic target;novel;novel therapeutics;Optics;optogenetics;Parvalbumins;patch clamp;Pathogenesis;Pathogenicity;Pathology;Patients;Personal Satisfaction;Physicians;Play;Population;Positioning Attribute;Presynaptic Terminals;Property;Publishing;Pyramidal Cells;Quality of life;reconstruction;Regulation;Resistance;Rest;Role;Schizophrenia;Scientist;SCN1A protein;Sensory;Slice;social;Sodium;Sodium Channel;somatosensory;Somatostatin;Subcellular Anatomy;Synapses;Synaptic Transmission;targeted treatment;Techniques;Therapeutic Intervention;therapeutic target;Training;Transcript;transcriptomics;transmission process;two-photon;United States;Variant;Vasoactive Intestinal Peptide;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Cellular and circuit function of Ndnf-expressing interneurons in a mouse model of a neurodevelopmental disorder


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: We will solve poorly defined mechanisms by which bacterial staphylocoagulase and streptokinase hijack the human hemostatic system, with critical involvement of host fibrin(ogen). Human prothrombin and plasminogen form active complexes with these bacterial proteins, and the complexes recognize fibrin(ogen) both as substrates and anchoring points. Knowledge of these mechanisms will allow development of new therapeutic antibodies that may protect patients with a fragile hemostatic system from adverse side effects of infection.

PI_NAMEs: GAILANI, DAVID ;VERHAMME, INGRID M (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: activation product;Active Sites;Antibiotic Resistance;Antibodies;Antiplasmin;Bacterial Endocarditis;Bacterial Proteins;bacterial resistance;Binding;Binding Sites;Blocking Antibodies;Blood Coagulation Disorders;C-terminal;Catalytic Domain;Church;Coagulation Process;cofactor;Collaborations;Combined Modality Therapy;Complex;Cross Reactions;Cryoelectron Microscopy;Data;design;Development;Environment;Enzyme Precursors;Epitopes;Equilibrium;Evaluation;expression vector;Extracellular Matrix Proteins;Fibrin;Fibrin fragment D;Fibrinogen;Fluorescence;Funding;Future;genetic variant;Goals;Hemostatic Agents;Hemostatic function;Host Defense Mechanism;Human;humanized monoclonal antibodies;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Infection;inhibitor;Innate Immune System;Invaded;Kinetics;Knowledge;Mediating;Methods;Modeling;Molecular Conformation;Monoclonal Antibodies;mouse model;murine monoclonal antibody;N-terminal;novel;novel therapeutics;Patients;Peptide Hydrolases;Physiological;Plasmin;Plasminogen;Preclinical Testing;prevent;Proteins;Prothrombin;Qualifying;Regulation;research clinical testing;Resources;Risk;Role;Scanning;Serotyping;side effect;Staphylocoagulase;Staphylococcus aureus;Streptococcus pyogenes;Streptokinase;Structure;Surface;System;Terminal Repeat Sequences;Testing;Therapeutic antibodies;Therapeutic Embolization;Thrombin;Thrombosis;Tissues;Trypsin;Vaccines;Variant;Virulence Factors;Work

PROJECT_TITLE: Roles of fibrin(ogen) in conformational activation of hemostatic proteinase precursors

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Neuropsychiatric conditions that result from stress exposure, including anxiety and opioid use disorder, are often comorbid, debilitating to patients, and represent one of the highest public health spending burdens. This project is designed to investigate the neural mechanisms responsible for the initiation of anxiety and opioid use following stress by examining discrete stress-sensitive factors within the locus coeruleus to basolateral amygdala circuit. Specifically, by analyzing the contribution of locus coeruleus inflammation on basolateral amygdala norepinephrine activity and subsequent behavioral effects, these experiments will establish novel targets for the treatment of comorbid anxiety and opioid use disorders that result from stress exposure.

PI_NAMEs: SMILEY, CORA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Adrenergic Agents;Adrenergic Receptor;Affect;Amygdaloid structure;Animal Model;Animals;Anxiety;anxiety-like behavior;anxiety-related behavior;Behavior;Behavioral;behavioral pharmacology;biological adaptation to stress;Brain;Brain region;brain tissue;career;Clinical;comorbidity;conditioned place preference;Cues;Data;design;designer receptors exclusively activated by designer drugs;Development;Disease;drug seeking behavior;experience;Experimental Designs;experimental study;Exposure to;Extinction;Female;Future;Genetic;Genetic Techniques;glial activation;Goals;immune function;Implant;Incidence;Inflammation;Investigation;locus ceruleus structure;male;Marble;Measures;Mediating;Mediator;men;Mental Depression;Mental disorders;Microdialysis;Microglia;Mission;Modeling;neural;Neuroimmune;neuroinflammation;neuromechanism;neuropsychiatric disorder;neuropsychiatry;neurotransmission;noradrenergic;Norepinephrine;novel;Opioid;opioid abuse;opioid epidemic;opioid use;opioid use disorder;Oral;Output;Oxycodone;Patients;Pattern;Pharmaceutical Preparations;Physiological;Population;Post-Traumatic Stress Disorders;Pre-Clinical Model;Predisposition;Preventive treatment;Process;psychologic;Psychosocial Stress;Public Health;Rattus;receptor expression;Regulation;Research;Scientist;Sensory;Sex Differences;Signal Transduction;social defeat;social stress;Stimulus;Stress;Substance Use Disorder;System;Techniques;Testing;Training;transmission process;United States National Institutes of Health

PROJECT_TITLE: Locus coeruleus-norepinephrine regulation of stress-induced anxiety and opioid reinstatement


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Effective smoking cessation treatments that reach the target population of young adults are direly needed and smartphone interventions are a promising strategy. Few of the available smoking cessation apps are based on evidence or deliver intervention content tailored to participant-specific high-risk situations for smoking. The aim of this proposal is to test smartphone-delivered messages for smoking cessation and urge reduction among young adults that target specific high-risk situations for smoking and have the potential to curb smoking in this underserved age group.

PI_NAMEs: THRUL, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: Abstinence;Adolescent;Affect;Age;age group;alcohol and other drug;Alcohols;Area;Biochemical;Cannabis;Cellular Phone;Cigarette;Clinical Practice Guideline;cognitive testing;Cognitive Therapy;comparison control;Control Groups;coping;Coping Skills;Data;design;Devices;Dose;Ecological momentary assessment;Educational process of instructing;efficacy evaluation;efficacy testing;Electronic cigarette;evidence base;Evidence based intervention;experience;Exposure to;Facebook;flexibility;follow-up;Future;Goals;group intervention;handheld mobile device;high risk;Home;Individual;interest;Intervention;intervention effect;Life;Light;Location;mindfulness;Morbidity - disease rate;mortality;novel strategies;Outcome;Participant;Patients;Persons;Phase;Population;Premature Mortality;Prevalence;primary outcome;Probability;Protocols documentation;psychologic;Randomized;randomized trial;randomized, clinical trials;Research;response;secondary analysis;secondary outcome;Services;smartphone application;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking relapse;Smoking treatment;Stress;Surveys;tailored messaging;Target Populations;Testing;Therapeutic Intervention;Time;Tobacco;Tobacco smoking behavior;Tobacco use;United States;virtual;Work;young adult

PROJECT_TITLE: Testing the impact of smartphone-based messaging to support young adult smoking cessation


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: WEN, SICHENG  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;Area;Award;Basic Science;Binding;Biological Markers;Biology;Bioreactors;Blood;Body Fluids;Bone Marrow;Brain;Cell secretion;Centers of Research Excellence;Cerebrospinal Fluid;checkpoint therapy;Chronic;Clinical;clinically significant;Code;Collaborations;Colon;Communities;Consultations;Core Facility;Coupled;Data Collection;Disease;disorder prevention;DNA;Effectiveness;Environment;experience;Experimental Designs;experimental study;extracellular vesicles;Feasibility Studies;fiber cell;Foundations;Funding;Grant;Harvest;Heart;HIV;Hospitals;Immune;Immune checkpoint inhibitor;Immunoassay;Immunooncology;Industry;Infant;Institution;instrumentation;intercellular communication;Laboratories;Large Intestine;Lasers;Lipids;liquid biopsy;Liver;Lung;Malignant neoplasm of lung;Mediating;Medical center;Medical Oncologist;Membrane;Messenger RNA;Methods;MicroRNAs;Molecular;Myocardial Ischemia;nanoparticle;Neurodegenerative Disorders;novel therapeutic intervention;Patients;Phase;Phenotype;Plasma;Play;Preparation;prevent;Proteins;Protocols documentation;Pulmonary Hypertension;Research;Research Personnel;Research Support;Rhode Island;Robot;Role;Saliva;Services;stem cells;Surface;Suspensions;System;Techniques;Time;Tissues;transcriptome sequencing;Translational Research;Translations;United States National Institutes of Health;Universities;Untranslated RNA;Woman

PROJECT_TITLE: Extracellular Vesicle Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biomedical Imaging;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: NARRATIVE An established hallmark of acute respiratory distress syndrome (ARDS) is the accumulation of liquid within alveoli that mechanically compromises their inflation and deflation, yet the key impacts on capillary hemodynamics and immune cell activity remain poorly understood. To address this issue, we have created the LungEx system, a novel technology that allows for mechanistic probing of lung respiratory-circulatory mechanics coupled with real- time imaging of lung dynamics at the single alveolar-capillary level. This proposal aims to use LungEx to establish causal links between lung mechanics and the underlying immunovascular dynamics and biology in ARDS-related lung injury.

PI_NAMEs: SHI, LINZHENG  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Affect;Air;Alveolar;alveolar epithelium;Alveolus;Biology;Biophysical Process;Blood capillaries;Blood Vessels;Boston;career;cell motility;cell type;Cells;Circulation;clinical practice;Communication;Coupled;Data;Death Rate;Diffusion;Edema;Endothelium;epithelial injury;Erythrocytes;Event;Experimental Designs;Fellowship;Functional disorder;Gases;Goals;hemodynamics;Heterogeneity;Histologic;Hypoxia;Image;imaging modality;Immune;immune function;Immunity;Immunobiology;Immunology;Impairment;improved;in vivo;Infiltration;Inflammation;Inflammatory;Injury;interdisciplinary approach;Intervention;Knowledge;Label;Life;Link;Liquid substance;Lung;lung imaging;lung injury;lung preservation;Macrophage;Magnetic Resonance Imaging;Mechanical ventilation;Mechanics;Mentorship;Microcirculation;Microscopy;migration;Molecular Profiling;mouse model;Mus;Myeloid Cells;new technology;novel;novel therapeutics;Optics;Organ;Oxygen;oxygen transport;pathogen;Pathogenesis;Perfusion;Phagocytosis;Phenotype;physical science;Physicians;Physics;Physiology;Pneumonia;pre-doctoral;preservation;pressure;Prone Position;pulmonary function;Pulmonary Ventilation;real-time images;recruit;Reporter;Research;Resolution;respiratory;Respiratory Failure;response;rib bone structure;Role;Scientist;Streptococcus pneumoniae;Structure;Surface;System;Technology;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;trafficking;Training;transcriptomics;Universities;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Probing immunovascular mechanobiology in pneumonia-associated acute lung injury at the single capillary level


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project narrative Currently there are no clinically effective treatments to improve outcome after traumatic spinal cord injury (SCI). This proposal will examine the role of novel candidate mediators of secondary tissue damage following SCI. Hence, new therapeutic targets may be identified to enhance functional recovery after SCI.

PI_NAMEs: HETMAN, MICHAL  (contact);SARASWAT, SUJATA OHRI

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;adaptive immunity;Affect;Agonist;angiogenesis;Antioxidants;Apoptosis;Apoptotic;ARNTL gene;Arrhythmia;Atherosclerosis;biological adaptation to stress;Biological Process;Blood;Blood coagulation;Brain;cadherin 5;cancer cell;Cardiovascular Diseases;Cell Count;Cell Proliferation;cell type;Cells;Cervical spinal cord injury;Cessation of life;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical;Complex;Contusions;Cues;cytotoxic;Down-Regulation;Drug Targeting;effective therapy;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Enhancers;experimental study;Extravasation;Feedback;feeding;Functional disorder;gain of function;Gene Expression;Genes;Genetic Transcription;Health;Hemoglobin;Hemorrhage;Homeostasis;Human;Impairment;improved;improved outcome;Inflammation;inhibitor;Injury;insight;Intervention;Intrinsic drive;Knock-out;life span;Light;Locomotor Recovery;loss of function;Macrophage;Malignant Neoplasms;Mediating;Mediator;Mental Depression;Metabolic syndrome;Microglia;Modeling;Molecular;mRNA Translation;Mus;Mutant Strains Mice;Natural Immunity;Nerve Degeneration;neuroinflammation;new therapeutic target;novel;Oligodendroglia;Organ;Outcome;Pathogenesis;Pathology;Periodicity;Permeability;pharmacologic;Phosphorylation;Play;Protein Kinase;Proteins;Proteolipids;Recovery;Recovery of Function;Regulation;Regulator Genes;Reporting;Repression;Research;RiboTag;Role;Secondary to;selective expression;Signal Transduction;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;systemic inflammatory response;Technology;Testing;Thoracic spinal cord structure;Time;tissue injury;Tissues;TNFRSF10B gene;Toxic effect;transcription factor;transcription factor CHOP;Transcription Repressor;transcriptome sequencing;translation factor;Vascular Diseases;white matter;white matter damage

PROJECT_TITLE: BMAL1/ARNTL plays a critical, non-circadian role in secondary tissue damage after contusive SCI

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: A large number of veterans are hospitalized and die from sepsis-induced acute kidney injury every year. Due to its poorly understood pathophysiological mechanisms, no effective therapy has been established to date. The proposed research is highly relevant to the VA's mission because the discovery of pathophysiological mechanisms involved in sepsis-induced kidney injury will lead to the development of rational therapeutic and preventative interventions.

PI_NAMEs: HATO, TAKASHI  (contact)

PROJECT_TERMS: Acetyltransferase;Acute Renal Failure with Renal Papillary Necrosis;Adenosine;Affect;Anabolism;Animal Model;arms race;Biological Process;Cell Physiology;Cell Survival;cell type;Clinical;Clinical Trials;Codon Nucleotides;Complex;Data;Development;Disadvantaged;DNA;effective therapy;eIF-5A;Enzymes;Epithelium;Equilibrium;fitness;Functional disorder;gain of function;Genes;Genetic;genome-wide;Goals;Heart;Hospitalization;Immune;Immune response;Inflammatory;inhibitor;Injury to Kidney;innovation;Inosine;Interferons;Kidney;Knowledge;Life;Link;Macrophage;Maps;Messenger RNA;Metabolism;microbial;Mission;Molecular;Molecular Profiling;mouse model;novel;Open Reading Frames;Outcome;Oxidation-Reduction;pathogen;Pathway interactions;Patients;personalized approach;pharmacologic;Phase;Phenotype;Polyamine Catabolism;Polyamines;polyproline;Post-Translational Protein Processing;preventive intervention;Production;protective pathway;Protein Biosynthesis;Putrescine;Recovery;Regulation;Renal function;Research;Resolution;response;Ribosomes;Role;Sepsis;septic;Spermidine;Spermidine/Spermine N1-Acetyltransferase;Spermine;success;Terminator Codon;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Time;timeline;tissue injury;Tissues;Translating;translation factor;Translational Regulation;Translations;Up-Regulation;Veterans

PROJECT_TITLE: Protective pathways in sepsis-induced renal injury


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Bipolar disorder (BD) is a common mental illness that affects 1-2% of the world’s population and ~100,000 veterans, causing mood symptoms, social/occupational disability and elevated rates of suicide. BD is associated with disruptions in daily (circadian) rhythms in sleep and activity. Lithium is an inexpensive, effective treatment for BD that protects neurons, and restores circadian rhythms. However, 30-50% of patients with BD fail respond adequately to lithium treatment. Lithium non-responsive patients often experience delays in receiving effective treatment and may require more expensive drugs. Our previous work indicates that circadian rhythm differences may help to identify lithium-responsive BD patients. Using newly-developed cell biology methods, we can now grow neurons from skin cells given by human donors. In this study, we use this approach to investigate circadian rhythm abnormalities in neurons from BD patients, and link circadian rhythm abnormalities with genetic factors previously tied to lithium-responsive BD.

PI_NAMEs: MCCARTHY, MICHAEL JOSEPH (contact)

PROJECT_TERMS: Activity Cycles;Affect;Aftercare;Animal Model;Animals;ANK3 gene;Antipsychotic Agents;Biological Assay;Biological Markers;Bipolar Disorder;Bipolar Neuron;Candidate Disease Gene;Cell model;cell type;Cells;Cellular biology;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;clinical predictors;Corpus striatum structure;Curiosities;Data;design;Diagnosis;Diagnostic;disability;Disease;Dopamine;Dopamine D2 Receptor;drug action;effective therapy;Environmental Risk Factor;excitatory neuron;experience;Extended Family;Fibroblasts;Foundations;Future;Genes;Genetic;Genetic Risk;Genetic study;genome wide association study;Glutamates;Heritability;Human;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;knock-down;Light;Link;Lithium;loss of function;Maintenance Therapy;Measures;member;Mental disorders;mesolimbic system;Methods;Modeling;Molecular Biology;molecular clock;Mood Disorders;mood symptom;Moods;nerve stem cell;Neurons;novel;Occupational;Ontology;Pathway Analysis;Patients;Periodicity;Pharmaceutical Preparations;Phase;Phenotype;polygenic risk score;Population;Prediction of Response to Therapy;preference;Process;Protocols documentation;Reporter;Research;response;Risk;Risk Factors;risk variant;Role;Sampling;severe mental illness;Signal Transduction;Skin;Sleep;Small Interfering RNA;social;stem cell model;suicide rate;System;TCF7L2 gene;Temperature;Time;transcriptome;transcriptome sequencing;Veterans;Work

PROJECT_TITLE: Circadian Rhythms in Neuronal Models of Bipolar Disorder


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Blast exposure caused by explosions is an exceedingly common event in the Iraq and Afghanistan Wars, and is a major source of trauma, often resulting in mild traumatic brain injury (mTBI). Very frequently, Veterans with mTBI also have comorbid posttraumatic stress disorder (PTSD), depression, and/or addiction. While an estimated 400,000 Veterans have a history of blast mTBI, the underlying mechanisms are not fully understood, and treatment options have limited benefits. To fill these gaps, we propose to study a chemical messenger system (the dynorphin/kappa opioid receptor system) that plays a critical role in trauma-induced behavioral problems. We will test two different drugs to inhibit this system, one long-lasting and one short-lasting. We hope to determine mechanisms of chronic mTBI-related behavioral problems and to identify a potentially effective treatment to improve chronic blast mTBI-induced behavior problems related to PTSD, depression, and addiction.

PI_NAMEs: SCHINDLER, ABIGAIL G (contact)

PROJECT_TERMS: Acute;addiction;Afghanistan;Animal Model;antagonist;Basal Cell;Behavior;Behavioral;behavioral impairment;behavioral outcome;biological adaptation to stress;blast exposure;Chemicals;Chronic;Chronic stress;Clinical;Clinical Trials;clinically relevant;cognitive function;comorbidity;Competitive Binding;cost;Cues;daily functioning;Data;design;Development;Disparate;Dopamine;Dynorphins;dysphoria;effective therapy;Event;Executive Dysfunction;executive function;experience;Explosion;Exposure to;Female;flexibility;Foundations;Functional disorder;Funding;Goals;Impairment;improved;Impulsivity;Inflammation;Injury;insight;Investigation;Iraq;K-Series Research Career Programs;kappa opioid receptors;Knowledge;male;Mediating;Mediator;Mental Depression;Mental Health;mesolimbic system;mild traumatic brain injury;Modeling;Morbidity - disease rate;mortality;Motivation;multimodality;Mus;Nature;negative affect;Neuroglia;Neurons;neuropsychiatric disorder;neurotransmission;new therapeutic target;Occupational;Opioid Antagonist;Outcome;Pathology;Pharmaceutical Preparations;Phase;Physiological;Play;Population;Post-Traumatic Stress Disorders;pre-clinical research;Problem behavior;prophylactic;Psychopathology;Quality of life;receptor;Receptor Activation;Recording of previous events;Reporting;Research Subjects;response;Risk;Rodent Model;Role;service member;sex as a biological variable;Sex Differences;Shock;social;Source;Stress;System;Testing;Therapeutic;Time;Translating;Trauma;trauma exposure;traumatic stress;Treatment Efficacy;Tube;United States;Veterans;War;Work

PROJECT_TITLE: Causal mechanism and therapeutic potential of the dynorphin/kappa opioid receptor system in blast-induced psychopathology


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative:  Advanced glycation end products and serum protein infiltration is one of the leading mechanisms that cause structural valve degeneration of bioprosthetic heart valves. The proposed research aims to further elucidate the basis of this mechanism by examining the effects of pretreating bioprosthetic heart valve leaflet material with two model compounds: pyridoxamine, an AGE-inhibitor, and Poly-2-methyl-2-oxazoline, which we have shown to significantly reduce protein infiltration. This work will provide insight into novel strategies to potentially mitigate AGE and serum protein infiltration and enhance biocompatibility, thus circumventing a leading mechanism of SVD that has not been investigated before.

PI_NAMEs: THOMAS, TINA  (contact)

PROJECT_TERMS: Adhesions;Advanced Glycosylation End Products;Affect;Animals;Biocompatible Materials;Biological Models;biomaterial compatibility;Bioprosthesis device;Blood;calcification;Calcium;Cattle;Cell Adhesion;Cell Culture Techniques;cell growth;Cell Survival;Cell-Matrix Junction;Cells;Clinical;Collagen;efficacy study;Endothelial Cells;Endothelium;Ethanol;Exclusion;Exposure to;FDA approved;Feasibility Studies;Fellowship;Functional disorder;Generations;Glutaral;Harvest;Heart Valve Diseases;Heart Valves;Human;Immunohistochemistry;Impairment;Implant;In Vitro;in vivo;Incubated;Individual;Infiltration;Inflammatory;inhibitor;innovation;insight;intercellular cell adhesion molecule;Intervention;Knowledge;Mediating;Methodology;Microscopy;Modeling;Modification;novel strategies;Oral Administration;Pathology;Patients;pericardial sac;Persons;pre-doctoral;Prevention;Proteins;Publications;Publishing;Pyridoxamine;Rattus;receptor expression;receptor for advanced glycation endproducts;Repeat Surgery;Research;Research Design;Research Training;second harmonic;Serum;Serum Albumin;Serum Proteins;simulation;Stains;subcutaneous;Surface;surface coating;Time;uptake;Vascular Cell Adhesion Molecule-1;Vitamin B6;Work;Xenograft procedure

PROJECT_TITLE: Pathophysiology and prevention of degeneration of heterograft biomaterials due to advanced glycation end products and serum protein infiltration


PI_NAMEs: HEAD, BRIAN P (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;astrogliosis;axon growth;Axonal Transport;Biochemistry;Brain;Brain Injuries;caveolin 1;Caveolins;Cell Line;Cell membrane;chronic traumatic encephalopathy;Clinical;Clinical Trials;cognitive function;Complex;Data;Dementia;Deposition;Disease;Dose;Early Onset Familial Alzheimer's Disease;Environment;Equilibrium;Etiology;Exhibits;Female;gene therapy;Growth;Health Care Costs;high risk;Hippocampus;Human;human old age (65+);Impairment;improved;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Injury;Intervention;Learning;Link;male;Mediating;Membrane;Membrane Microdomains;Memory;Memory impairment;Mental Depression;military service;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular Target;Morphology;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Plasticity;neuronal survival;Neurons;neuropathology;neuroprotection;neurotoxic;neurotransmission;old mice;overexpression;Patients;Persons;Phosphorylation;Population;Post-Traumatic Stress Disorders;pre-clinical;preservation;prevent;Production;promoter;protein expression;Regimen;resilience;Role;Scaffolding Protein;Senile Plaques;side effect;Signal Transduction;Stress;Structure;Synapses;Synapsins;synaptic function;Synaptic plasticity;Therapeutic;Time;Traumatic Brain Injury;Tyrosine;Veterans;Work

PROJECT_TITLE: Caveolin-Mediated Neuroplasticity in Alzheimer's Disease and in Human Neurons Harboring EOFAD Mutations


ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Single nucleotide polymorphism (SNP) rs1421085 has one of the strongest associations with obesity in the entire human genome and is associated with iroquois homeobox protein 3 (IRX3) expression. The proposed research will investigate a brain circuit potentially mediating the association between rs1421085, IRX3, and obesity. This will provide critical knowledge concerning genetic disposition to obesity and aid in the development of therapeutics to reduce or reverse obesity.

PI_NAMEs: SULLIVAN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adult;Animal Model;Bilateral;Binding Sites;Body Composition;Body Weight;Brain;Brain region;Cell Nucleus;chromatin immunoprecipitation;Data;Dependovirus;Dose;Eating;Electrophysiology (science);Energy Metabolism;Exhibits;Fatty acid glycerol esters;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genomic locus;High Fat Diet;Homeodomain Proteins;Homeostasis;Human;Human Genome;Hypothalamic structure;innovation;insight;Introns;Knowledge;Mediating;Metabolic;metabolic phenotype;Metabolism;Molecular;Monitor;mouse model;mRNA Expression;Mus;neuronal excitability;Neurons;neurophysiology;novel;Obesity;Obesity Epidemic;patch clamp;Phenotype;Physiological;promoter;Regulation;Reporter;Reporting;Research;risk variant;Role;Sampling;Single Nucleotide Polymorphism;single-cell RNA sequencing;therapeutic development;transcription factor;Transcription Repressor;transcriptional reprogramming;Untranslated RNA;Viral Vector;Weight Gain

PROJECT_TITLE: The Role of IRX3 Neurons in the Regulation of Body Weight Homeostasis


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Prevention

PI_NAMEs: LIANG, OLIN D. (contact)

PROJECT_TERMS: 2019-nCoV;Address;adeno-associated viral vector;Adenoviruses;Adoption;Aging;Animal Model;Basic Science;bi-specific T cell engager;Biology;Biomedical Research;Caliber;Cancer Center;cancer therapy;Cardiovascular system;catalyst;Cell Physiology;Cells;Cellular biology;Centers of Research Excellence;clinical application;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;Communities;cost;Country;COVID-19;COVID-19 pandemic;Data;Dependovirus;design;Development;diagnostic tool;Disease;experimental study;Faculty;Fees;Funding;Gene Delivery;gene therapy;Gene Transduction Agent;gene transfer vector;Genes;Genetic Diseases;Genetic Engineering;Goals;Grant;Growth;Health;Health Services Research;Hematologic Neoplasms;Hospitals;Human;immunotherapeutic virotherapy;improved;Infrastructure;innovation;Institution;interest;Interphase Cell;K-Series Research Career Programs;Knock-out;Laboratories;laboratory equipment;Lentivirus;Malignant Neoplasms;Mediating;Medical center;medical schools;meetings;member;Methods;Modernization;Molecular Biology;Monitor;Neurosciences;New England;novel;novel diagnostics;novel therapeutics;oncolytic adenovirus;Orthopedics;overexpression;Pathogenesis;Phase;Physicians;Physiological;Population;Prevention;Production;recombinant viral vector;Research;Research Activity;research facility;Research Personnel;Rest;Rhode Island;Role;Scientist;Secure;Series;service providers;Services;Solid Neoplasm;sound;stem cells;Strategic Planning;System;Techniques;Technology;Technology Transfer;Tissues;tool;Translational Research;translational research program;United States National Institutes of Health;Universities;Vaccination;Variant;vector;Veins;Viral;Viral Genes;Viral Vector;Virus

PROJECT_TITLE: Lentivirus Construct Core


PHR: Chemicals in the brain called neurotransmitters control virtually every aspect of brain function. Neurotransmitters do this by activating specific proteins, called neurotransmitter receptors. Neurotransmitter receptors allow us to talk, walk, make new memories, and even fall asleep. These same neurotransmitter receptors behave differently after brain injury and contribute to neurologic symptoms including depression and epileptic seizures. Because of the aging population and the current prolonged military conflicts, the number of veterans with epileptic seizures caused by stroke and traumatic brain injury is increasing. Improved understanding of how neurotransmitter receptors are affected in these diseases is vital to develop more effective therapies.

PI_NAMEs: RANSOM, CHRISTOPHER BRUCE (contact)

PROJECT_TERMS: active duty;Acute;Affect;aging population;Animals;antagonist;anti-epileptic agents;Antiepileptogenic;Area;Attenuated;attenuation;Axon;axonal sprouting;Biochemical;Brain;brain cell;Brain Injuries;Cerebellum;Cessation of life;Characteristics;Chemicals;Chronic;Cognitive;controlled cortical impact;Data;dentate gyrus;Dependence;Diet;Disease;Down-Regulation;effective therapy;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;experimental study;Exposure to;falls;Functional disorder;Future;G-Protein-Coupled Receptors;GABA Receptor;GABA-A Receptor;granule cell;Health;high risk;Hippocampus;Histologic;Human Resources;Immune;improved;Incidence;Inflammatory;inhibitor;injured;Injury;insight;Interneurons;Intractable Epilepsy;Investigation;Knowledge;Macrophage Colony-Stimulating Factor Receptor;Memory;Mental Depression;Microglia;Military Personnel;military veteran;Modeling;Molecular;Monitor;mossy fiber;Mus;Neurologic Symptoms;neuron loss;Neurons;neuropsychiatry;Neurotransmitter Receptor;Neurotransmitters;novel;Outcome;patch clamp;Penetration;pharmacologic;Post-Traumatic Epilepsy;postsynaptic;Property;Proteins;receptor;receptor expression;receptor function;Regulation;Resistance;response;response to injury;Role;Seizures;Services;Severities;Signal Transduction;Slice;Stroke;Synapses;Techniques;Testing;Thalamic structure;Therapeutic;Time;tool;Traumatic Brain Injury;Veterans;virtual;Walking;Work

PROJECT_TITLE: Regulation of extraysynaptic GABA-A receptors in health and disease


ORG_CITY: PHOENIX

ORG_NAME: PHOENIX VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: Project Narrative  Vascular dementia (VaD) is a condition that arises from development of cerebrovascular disease leading to decreased flow to the brain that causes degeneration and inflammation of brain tissue. It is the second most common cause of dementia overall and an important clinical problem among veterans and the general public. To prevent or manage VaD, we need better understanding of its early development, identify factors that exacerbate the condition and develop new ways of treatment. The goal of this proposal is to investigate how the aging blood vessel, characterized by inflammation caused by agents such as medin (a protein that accumulates with aging) as well as cardiovascular risk factors (increased lipid and glucose), could lead to inflammation and degeneration of brain cells and test a novel treatment agent, monosialoganglioside nanoliposome, to protect brain cells against hypoxic injury. The proposal could impact our fundamental understanding of the genesis of VaD and identify new molecular targets and treatment interventions to prevent or control the disease.

PI_NAMEs: MIGRINO, RAYMOND QUEZON (contact)

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Adult;Affect;Aging;aging related;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid Proteins;Antioxidants;Astrocytes;Autopsy;Biochemistry;Biological;Biology;Biomedical Engineering;Blood Vessels;blood-brain barrier function;Brain;brain cell;brain endothelial cell;Brain Hypoxia-Ischemia;Brain Injuries;brain tissue;cardiovascular risk factor;Cardiovascular system;Cell Survival;Cells;cerebral artery;cerebral vascularization;cerebrovascular;Cerebrovascular Disorders;Clinical;Cognition;Cognitive;Coupling;Data;Dementia;Development;Diabetes Mellitus;disability;disorder control;efficacy testing;Encephalitis;Endothelial Cells;endothelial dysfunction;Exposure to;Functional disorder;General Population;Glucose;Goals;Health Care Costs;Healthcare;Human;human old age (65+);human tissue;Hyperlipidemia;Hypoxia;Hypoxic Brain Damage;Impaired cognition;in vivo;Inflammation;Inflammatory;Injury;Intervention;Investigation;Ischemia;Ischemic Penumbra;Ischemic Stroke;Learning;Link;Lipids;Long term disability;Maintenance;medin;Metabolic;Middle Cerebral Artery Occlusion;military veteran;Modeling;Molecular;Molecular Probes;Molecular Target;mortality;multidisciplinary;Mus;nanoliposome;nanoscience;Nerve Degeneration;neural;neuroinflammation;Neurons;neuropathology;Neurophysiology - biologic function;neurosurgery;neurotransmission;neurovascular unit;novel;novel therapeutics;nuclear factor-erythroid 2;organ on a chip;Oxidative Stress Induction;Palmitic Acids;particle;Patients;Peptide Initiation Factors;Phospholipids;prevent;Process;Proteins;Reperfusion Injury;Reperfusion Therapy;Role;sialogangliosides;Signal Transduction;Stress;Stroke;stroke model;Testing;Tissue Donors;Tissue Model;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;vascular inflammation;Veterans

PROJECT_TITLE: Discovering Novel Mechanisms and Treatment for Aging-Related Dementia: Probing Medin and Abeta Vasculopathy


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Contact PD/PI: LEE, ABRAHAM Acoustic microvortices instrumentation for dosage controlled, high efficiency cell engineering Narrative Nonviral transfection methods are alternatives to viral vectors that avoid the deleterious byproducts such as immune-mediated toxicity and oncogenic transgene concerns. In this application we propose to develop an acoustic-electric shear orbiting poration (AESOP) microfluidic instrument to achieve uniform dosage and high efficiency intracellular delivery of large-size exogenous cargos. We will benchmark AESOP by the technical requirements of engineering primary T cells and chimeric antigen receptor (CAR) T cells for developing universal CAR T cells for immunotherapy.

PI_NAMEs: LEE, ABRAHAM P (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Allogenic;Automation;Award;Benchmarking;cancer immunotherapy;Cell membrane;Cell Membrane Permeability;Cell Nucleus;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Cellular Phone;chimeric antigen receptor T cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cost;CRISPR/Cas technology;Cytoplasm;design;Development;Diffusion;dosage;electric field;Engineered Gene;Engineering;Exposure to;Frequencies;Gene Modified;Genes;Genetic;Genetic Engineering;Goals;Harvest;Human;Immune;Immunologics;Immunotherapy;innovation;instrument;instrumentation;Knock-out;Lateral;Malignant Neoplasms;Mechanics;Mediating;Membrane;membrane excitation;Messenger RNA;Methods;Microfluidics;Molecular;nanopore;Nobel Prize;Nucleic Acids;Ocular orbit;Oncogenic;Outcome;Plasmids;Population;portability;Preparation;Process;Proteins;prototype;Pump;Reagent;Rotation;Safety;Sampling;Stream;success;System;T-Lymphocyte;Techniques;technological innovation;technology development;Toxic effect;Transducers;Transfection;Transgenes;Viral Vector

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Problems with attention, concentration, and cognition are major features of many disorders that are prevalent in US veterans including sleep disorders, traumatic brain injury (TBI) and Alzheimer's disease (AD). We have identified a population of basal forebrain neurons that when stimulated in mice produce cortical activation, alertness, and enhance attention-dependent performance in a reaction time test, and in an associative learning test. The basic research proposed will test the ability of these neurons to rescue the attention and cognitive impairments produced by sleep loss. Veterans, especially those who suffer from TBI and PTSD have a very high incidence of sleep problems, with sleep apnea and chronic insomnia being the most common. Once sleep problems arise, they also exacerbate many of these health conditions. Future work will apply the therapeutic approach investigated here to mouse models of TBI and AD – disorders that are of great importance to US Veterans.

PI_NAMEs: MCKENNA, JAMES TIMOTHY (contact);STRECKER, ROBERT E

PROJECT_TERMS: 3-Dimensional;Acceleration;Accidents;Affect;alertness;Alzheimer's Disease;Alzheimer's disease model;Arousal;Association Learning;Attention;attentional control;Attentional deficit;Auditory;basal forebrain;basal forebrain cholinergic neurons;Basic Science;Behavior;behavior measurement;behavior test;Behavioral;brain circuitry;Chronic Insomnia;Cognition;Cognitive;conditioned place preference;Cues;Data;Dementia;discrimination task;Disease;Drowsiness;Electrophysiology (science);Excessive Daytime Sleepiness;experimental study;Fiber;Frequencies;Future;Goals;Grant;habituation;Health;Human;Hunger;Impaired cognition;Impairment;improved;In Vitro;in vivo;Incidence;Investigation;Knowledge;Lasers;Lead;Learning;Light;Literature;Measures;Mediating;Mental Depression;Methods;military veteran;Modeling;Motivation;mouse model;Mus;Neurons;novel;novel therapeutics;optogenetics;Parvalbumins;Pathway interactions;Pattern;Performance;pharmacologic;Photometry;Physiological;Population;Post-Traumatic Stress Disorders;predictive modeling;Productivity;Proxy;Reaction Time;receptor;Regulation;Reporting;response;Rewards;Rodent;Role;Schizophrenia;Self Stimulation;Sensory;sensory cortex;sensory stimulus;side effect;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Substance Use Disorder;sustained attention;Symptoms;Task Performances;Testing;Therapeutic;therapy development;Time;Traumatic Brain Injury;Veterans;vigilance;Visual;visual discrimination;Wakefulness;Work;Workplace

PROJECT_TITLE: Role of the basal forebrain in sleep loss induced attention impairments


PHR: Chronic kidney disease (CKD) kills almost 90,0000 Americans every year, more than the death rate with cancers of the breast and prostate combined. While more than 20 million U.S. adults suffer from CKD, the rates are higher among Veterans. Moreover, Veterans with CKD also have much higher rates of other diseases such as diabetes, high blood pressure, and heart disease. Some forms of injury to the kidney can be temporary, referred to as acute kidney injury (AKI). However, recent research suggests that even AKI can cause CKD by itself. When AKI occurs in the setting of CKD, it can worsen CKD to complete kidney failure as has been shown in several studies in the Veteran population. CKD itself can impede the recovery from AKI. The specific mechanisms that lead to these poor outcomes are not well known. The main goal of this project is to identify the specific pathways that cause the interactions between AKI and CKD and lead to worsening of kidney disease. The results of these studies could lead to early interventions and medications to improve the health of the Veteran population.

PI_NAMEs: SINGH, PRABHLEEN  (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acute Renal Failure with Renal Papillary Necrosis;Address;adenylate kinase;Adult;American;Biomass;Cardiovascular Diseases;Caring;Cell Proliferation;Cells;Cellular Stress;Chronic Kidney Failure;Clinical;Clinical Research;clinically relevant;comorbidity;Coupled;Data;Death Rate;Dependence;Development;Diabetes Mellitus;Disease;Disease Progression;Early Intervention;Energy Metabolism;Enzymes;Fibrosis;Functional disorder;Gatekeeping;Genetic;Glucose;Glycolysis;Goals;Health;Heart Diseases;Hypertension;Hypoxia;Hypoxia Inducible Factor;Impairment;improved;Incidence;Injury;injury recovery;Injury to Kidney;insight;Investigation;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measures;Metabolic;Metabolism;metabolomics;Methodology;Methods;Micropuncture;military veteran;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mortality;Nephrectomy;novel;novel therapeutics;Organ;Outcome;Oxidative Phosphorylation;Pathway interactions;Patients;PDH kinase;Pharmaceutical Preparations;pharmacologic;Physiological;Predisposition;prevent;progression risk;Proliferating;Proximal Kidney Tubules;Pyruvate;pyruvate dehydrogenase;Recovery;Recovery of Function;Regulation;repaired;Research;Respiration;Role;sensor;Stress;Study models;Techniques;Therapeutic;Time;transcriptomics;treatment strategy;Tubular formation;Up-Regulation;Validation;Veterans;Work

PROJECT_TITLE: Renal Oxygenation and Mitochondrial Function in the in the Pathophysiology of Kidney Disease


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Tolerance to ischemia can be induced by various methods or drugs nowadays to minimize damage to organs that are deprived of blood supply. However, our ability in developing resistance to ischemia declines with age and metabolic diseases. The goal of this project is to determine the molecular mechanisms underlying the failed tolerance to stroke in type 2 diabetes. Data from our research suggest that this failure is closed linked to the modified immune response and chronic inflammation in subjects with type 2 diabetes. This proposed project will characterize these changes in order to find therapy to correct this condition.

PI_NAMEs: LIU, JIALING  (contact)

PROJECT_TERMS: Affect;Age;age related decline;Aging;Agonist;Anti-Inflammatory Agents;Attenuated;Biological Assay;Blood flow;Blood Vessels;brain cell;brain parenchyma;Cells;Cerebral Ischemia;Chronic;clinical application;Coagulation Process;comparison control;Compensation;conditioning;Data;db/db mouse;Defect;diabetic;Exposure to;Extravasation;Failure;Gene Expression;Genes;Goals;Heterogeneity;Hour;Human;Image;Immune;Immune response;immunoregulation;Immunosuppression;improved;Infarction;Inflammation;innate immune pathways;insight;Interferon-beta;Interferons;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Preconditioning;Ischemic Stroke;Knowledge;Leptomeninges;Leukocyte Trafficking;Leukocytes;Link;Mediating;Meningeal;Meninges;Metabolic Diseases;Methods;Microcirculatory Bed;Molecular;monocyte;Mus;Myeloid Cells;Natural Immunity;neurobehavior;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Optical Coherence Tomography;Organ;Paper;Pathologic;Peripheral;peripheral blood;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;post stroke;preconditioning;Reporting;Research;Resistance;Resistance development;response;sex;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stimulus;Stroke;stroke outcome;T-Cell Proliferation;technology platform;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thrombelastography;Thrombus;Time;Tissues;Toll-like receptors;transcriptome;Vascular blood supply;Velocimetries

PROJECT_TITLE: Mechanisms underlying dampened ischemic tolerance in type 2 diabetes


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine

ORG_NAME: RHODE ISLAND HOSPITAL

PI_NAMEs: DUBIELECKA-SZCZERBA, PATRYCJA MARTA (contact)

PROJECT_TERMS: Acceleration;age-related disease;Aging;Award;Basic Science;biobank;Biological Sciences;Biology of Aging;Cancer Center;Caring;Centers of Research Excellence;Clinic;Clinical;Clinical Data;clinical practice;Clinical Trials;Collaborations;Communities;Core Facility;Data Analyses;design;Development;Early identification;Education;Ensure;Evaluation;Event;extracellular vesicles;Extramural Activities;Feasibility Studies;Flow Cytometry;Fostering;Funding;Funding Mechanisms;Goals;graduate student;Grant;Healthcare;Hospitals;Infrastructure;Institution;instrumentation;inter-institutional;life span;Measures;medical schools;member;Mentors;Mentorship;Methodology;multidisciplinary;New England;Outcome;Outcome Measure;Phase;Pilot Projects;Play;Population;Prevention strategy;primary outcome;professor;Program Reviews;programs;recruit;Regenerative Medicine;Reproducibility;Request for Proposals;Research;Research Personnel;Resources;Rhode Island;Role;Science;Scientist;Secure;service programs;Services;stem cells;Strategic Planning;Structure;success;synergism;Technology;Time;Tissues;Training;Translating;translational approach;translational impact;translational potential;translational scientist;Translations;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Vision;voucher;Wages;Work

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Genetics;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Mitochondria are tiny bacterium-sized organelles, located in essentially every cell of the body, that play a critical and central role in producing approximately almost all of the energy in the body; if something goes wrong with the machinery running this "bioenergetic" factory, cells, and especially those with high energy demands, such as brain, heart, and muscle, begin to "run out of gas," and will eventually die. We have discovered that in cells from patients with defective mitochondrial energy production (i.e. mitochondrial disease), there is a "ripple effect" on the rest of the cell that is mediated by a disruption in the physical connections between mitochondria and endoplasmic reticulum (ER), an organelle that is required for numerous functions, including the distribution of proteins throughout the cell, lipid metabolism, calcium metabolism, and responses to stress. We propose here to study how reduced energy production in mitochondrial disease patients alters ER-mitochondrial connectivity and communication, with the ultimate goal of using this knowledge to "reverse" the connectivity defect as a way to treat these devastating and often fatal disorders.

PI_NAMEs: SCHON, ERIC A. (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TITLE: Aberrant ER-Mitochondria Communication in Human Mitochondrial Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]