NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE. Precision medicines that specifically target proteins that drive cancer growth are leading to improved responses in many advanced-stage cancer patients. However, this clinical success is limited because treatment resistance occurs. The studies in this grant proposal focus on the characterization of a mechanism of tumor cell persistence and resistance to signaling pathway targeted therapies in lung cancer, with the overall goal of enhancing survival outcome for cancer patients through improved precision medicine strategies.

PI_NAMEs: BIVONA, TREVER G (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adenocarcinoma;Alveolar;Alveolar Cell;Applications Grants;BCL2L1 gene;Biological;Biological Markers;cancer cell;Cancer Etiology;Cancer Patient;Cell Survival;cell type;Cells;Clinical;clinical development;clinical translation;Clinical Trials;clinically relevant;cohort;Companions;Data;Disease Outcome;Disease Reservoirs;Drug resistance;Drug Tolerance;efficacy evaluation;Epidermal Growth Factor Receptor;ERBB2 gene;Evolution;FGFR1 gene;Funding;Future;Gene Expression Profile;Genetic Transcription;Goals;Growth;Histologic;improved;In Vitro;inhibitor;innovation;insight;KRAS2 gene;Link;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Mediating;Molecular;molecular marker;mortality;multidisciplinary;mutant;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Nuclear;Oncogenes;Oncogenic;Oncoproteins;Outcome;Output;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Pre-Clinical Model;precision medicine;primitive cell;Proteins;PTPN11 gene;Ras Inhibitor;Regimen;Residual Cancers;Residual Neoplasm;Resistance;response;Role;Safety;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;small molecule inhibitor;Specimen;success;survival outcome;Switch Genes;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;tumor;Up-Regulation;Work

PROJECT_TITLE: Characterization of YAP as a rational companion target in lung cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Reliable non-invasive differentiation of aggressive vs. indolent prostate cancer is imperative for the early detection of aggressive cancers (currently missed in ~50,000 American men/year) while minimizing side effects from unneeded biopsies (currently affecting ~500,000 American men/year). We propose to develop pathomic MRI biomarkers and include them in rad-pathomic deep learning models to learn the appearance of aggressive and indolent cancers on MRI from patients with matched MR and pathology images. We will validate our deep learning models when assisting radiologists in detecting aggressive cancers on prostate MRI.

PI_NAMEs: RUSU, MIRABELA  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Affect;Agreement;American;Appearance;Atlas of Cancer Mortality in the United States;Benign;Biological Markers;Biopsy;Biopsy Specimen;cancer care;Cancer Detection;Cessation of life;Data Set;deep learning;deep learning model;Detection;detection method;Early Diagnosis;Hemorrhage;improved;indexing;Indolent;Infection;innovation;Label;Learning;learning strategy;Lesion;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Methods;Modeling;multidisciplinary;novel;Pain;Pathologist;Pathology;pathology imaging;Patients;Pattern;Positioning Attribute;Prostate;prostate biopsy;Prostatectomy;Radical Prostatectomy;radiological imaging;radiologist;Reader;Screening for Prostate Cancer;side effect;Slice;Specificity;Testing;Tissues;Training;Visual

PROJECT_TITLE: Rad-pathomic deep learning models to assist radiologists in differentiating aggressive from indolent prostate cancer on MRI


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Project Lead: Murphy, Susan Principal Investigator: Kumar, Santosh TR&D2: Dynamic Optimization of Continuously Adapting mHealth Interventions via Prudent,  Statistically Efficient, and Coherent Reinforcement Learning  Lead: Dr. Susan Murphy, Harvard University; 10% effort (1.2CM) Public Health Relevance: TR&D2 will take advantage of the recent developments in wearable and sensor technology to provide precision interventions to individuals at optimal times and locations so as to provide maximal health benefit. TR&D2 will thus enable a new, powerful approach to personalizing mobile health interventions, enabling patients to initiate and sustain the healthy lifestyle choices necessary to prevent and/or successfully manage the growing burden of multiple chronic conditions. 1

PI_NAMEs: MURPHY, SUSAN A (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;Behavioral;Biological Markers;biopsychosocial;burden of chronic illness;Cellular Phone;Clinical;cloud based;Cloud Computing;cohort;Collaborations;Communities;Companions;Data;data sharing;Detection;Development;Distal;Distant;Ensure;Event;Feedback;flexibility;Future;habituation;Health;Health Benefit;Healthcare;healthy lifestyle;improved;Individual;Infrastructure;interest;Intervention;intervention delivery;intervention effect;Lead;Learning;learning algorithm;learning strategy;Location;Maps;Medical;Medicine;member;Methodology;Methods;mHealth;mhealth interventions;Modeling;multiple chronic conditions;next generation;online intervention;open source;Outcome;Patients;personalized decision;personalized intervention;Persons;Population;prevent;Principal Investigator;Psychological reinforcement;public health relevance;Research;Research Personnel;Resources;Risk;Risk Estimate;sensor;sensor technology;Services;social;Software Framework;software systems;Software Tools;Stress;Structure;synergism;System;technological innovation;Technology;technology research and development;Testing;Time;tool;Training;Translations;treatment effect;Treatment Efficacy;Universities;Variant;wearable device;Work

PROJECT_TITLE: mDOT TR&D2 (Optimization):  Dynamic Optimization of Continuously Adapting mHealth Interventions via Prudent, Statistically Efficient, and Coherent Reinforcement Learning


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Social interactions are critical to the normal development of the brain. A critical period is a developmental epoch during which the nervous system is expressly sensitive to specific stimuli that are required for experience dependent learning, circuit organization, and synaptic plasticity. Critical periods have been described for both sensory (e.g. vision, touch) and social (e.g. language, imprinting) functions. While mechanistic insights into the establishment and reinstatement of sensory critical periods have transformed therapeutic practice (e.g. for treating deafness and blindness), to date, the molecular, synaptic, and circuit mechanisms underlying social critical periods are largely unknown. Our proposed studies will have significant implications for understanding the pathogenesis of neurodevelopmental disorders characterized by social impairments, such as autism and schizophrenia, as well as diseases like addiction and PTSD that respond to social influence or are aggravated by social injury. At the same time, these insights will provide the basis for new therapeutic strategies, improved mechanistic understanding of therapeutic interventions currently in clinical trials, and objective measures of social reward learning across maturation that are tractable for future translational studies.

PI_NAMEs: DOLEN, GUL  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Ablation;Achievement;Acute;addiction;Address;Adult;Anatomy;Animals;Area;Argipressin;argipressin receptor;autism spectrum disorder;Axon;Bathing;Behavioral;Blindness;Brain;Brain region;Clinical Trials;conditioned place preference;critical period;Data;deafness;design;Development;Disease;experience;FLP recombinase;Frequencies;functional genomics;Future;Globus Pallidus;Goals;Human;Hypothalamic structure;Impairment;imprint;improved;in vivo;Injury;insight;Knock-in Mouse;Knock-out;Knockout Mice;Language;Learning;Long-Term Depression;magnocellular;Maps;Measures;Mediating;Methods;Molecular;Mus;Nature;Nervous System;Neurodevelopmental Disorder;Neurons;novel;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;optogenetics;Oxytocin;paraventricular nucleus;parvocellular;patch clamp;Pathogenesis;Physiologic pulse;Post-Traumatic Stress Disorders;postnatal;postsynaptic;premature;presynaptic;receptor;Regulation;Rewards;Role;Schizophrenia;Sensory;Signal Transduction;Slice;social;Social Behavior;Social Conditions;Social Environment;social influence;Social Interaction;Source;Stimulus;Synapses;synaptic function;Synaptic plasticity;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;tool;Touch sensation;translational neuroscience;translational study;Up-Regulation;V1a vasopressin receptor;Vasopressins;viral gene delivery;Vision

PROJECT_TITLE: Dissecting the role of vasopressin in regulating the critical period for social reward learning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE: Enhancers are regulatory DNA sequences within our genomes that control when and where genes are activated. In the myriad cell types in the human brain, enhancers direct transcriptional programs required for the genesis of neurons and glia and for constructing synapses and circuits. As such, enhancers are critically important to human brain evolution, development, and health, yet their function remains poorly understood. This project is focused on the development and implementation of novel approaches for decoding the function of enhancers and elucidating their role in the healthy and diseased brain.

PI_NAMEs: NORD, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Biological Assay;Brain;Brain Diseases;cell type;Cells;chromatin remodeling;Development;Disease;DNA;DNA Sequence;Elements;Enhancers;Ensure;Epigenetic Process;Evolution;Funding;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Transcription;Genome;Genomic approach;Genomics;Goals;Health;Human;Human Genome;in vivo;Label;Mediating;Methods;Modeling;Modification;Molecular;Neuroglia;Neurons;Neurosciences;novel strategies;Pathogenicity;Productivity;programs;Proteins;Regulatory Element;Research;Research Personnel;Role;Synapses;Time;Tissues;tool;transcription factor;Transcriptional Regulation;Untranslated RNA;Variant;Work

PROJECT_TITLE: Functional elucidation of the sequence-encoded regulatory activity of enhancers in vivo in the brain

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ALBANY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

ORG_STATE: NY

PHR: NARRATIVE We propose to develop Yersinia OMVs enclosing both protective antigens from Y. pestis as an effective acellular vaccine against plague.

PI_NAMEs: SUN, WEI  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Accidents;Acellular Vaccines;adaptive immune response;Adjuvant;aerosolized;African Green Monkey;Animals;Antibody Response;Antigen-Presenting Cells;Antigens;Attenuated Vaccines;B-Lymphocytes;Bacillus;Bacteria;Biological;Biological Warfare;bioweapon;Case Study;Characteristics;Classification;County;Cytosol;Disease;DNA;Dose;Drug Metabolic Detoxication;Economic Development;Epidemic;Etiology;FDA approved;Genetic;Genetic Polymorphism;Genetic Variation;Glycerophospholipids;Gram-Negative Bacteria;Grant;Human;Immune;Immune response;Immunity;Immunization;immunogenic;immunogenicity;improved;Infection;Inflammatory Response;Inhalation;Left;Licensing;Lipids;Lipopolysaccharides;Lung;Macaca fascicularis;Mass Vaccinations;Mediating;Membrane;Modification;mortality;Multi-Drug Resistance;Mus;nanosized;nanovesicle;National Security;Natural Source;Neisseria;Orphan Drugs;Pasteurella pseudotuberculosis;pathogen;periplasm;Phase III Clinical Trials;Plague;Plague Vaccine;Pneumonic Plague;prevent;protective efficacy;Proteins;Rattus;Recording of previous events;respiratory;response;RNA;Rodent;Role;Route;Safety;Shapes;Source;Subunit Vaccines;success;Symptoms;T cell response;T-Lymphocyte;transmission process;Vaccination;vaccine access;vaccine candidate;vaccine development;Vaccines;Variant;Vesicle;vesicular release;Virulent;weapons;Western World;World Health Organization;Yersinia;Yersinia pestis;Zoonoses

PROJECT_TITLE: Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The VA mandated expanded community care services for Veterans with the MISSION Act of 2018 and has increasingly partnered with community-based facilities to provide acute care for Veterans Living with Dementia (VLWD). Research shows that transitions across care systems are vulnerable times, resulting in fragmentation and worse health outcomes. Unfortunately, these Veterans are especially at an increased risk of adverse outcomes, resulting in continued deterioration. Our work will evaluate transitions of care from community hospitals to VA care using a mixed-methods approach. We will identify important risk factors that lead to adverse outcomes in transitions for dual-use VLWD, and then adapt and pilot an intervention to improve transitions of care that may be used for all VLWD being discharged from the community hospitals or ED. This work is a high priority area of VA’s MISSION Act implementation and is supported by the VA Offices of Geriatrics and Extended Care, Community Care, and Emergency Medicine.

PI_NAMEs: AYELE, ROMAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;acute care;Address;Adult;adverse outcome;Affect;Alzheimer's Disease;American;Area;Behavior;Benefits and Risks;care coordination;care fragmentation;care outcomes;care preference;care systems;career;career development;Caregivers;Caring;Chronic;Communities;community based care;community based service;Community Healthcare;Community Hospitals;Data;Dementia;design;Deterioration;Development;effectiveness study;effectiveness testing;Emergency Care;Emergency department visit;Emergency Medicine;Environment;evidence base;Evidence based intervention;Face;Family Caregiver;feasibility testing;Funding;Future;Geriatrics;Goals;Health;Health Care Costs;health care delivery;health care service utilization;Health Services Accessibility;Healthcare;high risk;Home;Homogeneously Staining Region;hospital care;Hospital Departments;hospital readmission;Hospitalization;Hospitals;human old age (65+);Impairment;implementation science;Improve Access;improved;improved outcome;Incidence;innovation;Institutionalization;Intention;Intervention;Interview;Investments;Judgment;Knowledge;Language;Length of Stay;Long-Term Care;Measures;Medication Management;Memory;Methodology;Methods;Modeling;mortality;Neurodegenerative Disorders;Outcome;Outcome Assessment;Patient Care;patient oriented;Patients;Pattern;pilot test;Policies;poor health outcome;Post-Traumatic Stress Disorders;pragmatic intervention;preference;Prevalence;prevent;Quality of Care;Recording of previous events;Research;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Safety;service delivery;Shapes;System;Testing;Traumatic Brain Injury;treatment as usual;Veterans;Veterans Health Administration;Visit;Work

PROJECT_TITLE: Optimizing Transitions for Dual-Use Veterans Living with Dementia followingHospitalization in the Community

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


PHR: Principal Investigator: Kumar, Santosh TR&D3: Translation of Temporally Precise mHealth via Efficient and Embeddable Privacy-aware  Biomarker Implementations  Lead: Dr. Emre Ertin, The Ohio State University; 10% effort (1.2 CM) Public Health Relevance: Algorithms, tools and software designed by TR&D3 will make it possible for temporally-precise mHealth interventions to be deployed to participants’ personal devices with appropriate privacy controls and minimal effect on battery and processor resources. Doing so will transformatively improve health and disease outcomes by enabling patients to initiate and sustain the healthy lifestyle choices necessary to prevent and/or successfully manage the growing burden of multiple chronic conditions. 2

PI_NAMEs: ERTIN, EMRE  (contact)

PROJECT_TERMS: Address;Algorithms;Architecture;Awareness;Behavioral;Biological Markers;biopsychosocial;burden of chronic illness;Cellular Phone;Clinic;Cloud Computing;cloud platform;Collaborations;Collection;Communication;Communities;Companions;Computational Technique;Computer software;Computing Methodologies;craving;Data;Data Collection;data sharing;denoising;design;Development;Devices;Digital biomarker;Disease Outcome;Eating;Ensure;Fatigue;Feedback;Frequencies;Generations;Health;Healthcare;healthy lifestyle;high dimensionality;Image;improved;Individual;Infrastructure;Intelligence;Intervention;Lead;Life;Life Cycle Stages;Machine Learning;machine learning algorithm;Medical;Medicine;Metadata;Methodology;Methods;mHealth;mhealth interventions;mobile computing;Modality;Motion;multiple chronic conditions;next generation;Noise;Observational Study;Ohio;open source;Participant;Patients;Personally Identifiable Information;Physiological;Physiology;point of care;prevent;Principal Investigator;Privacy;prototype;public health relevance;radio frequency;reconstruction;Research;Research Activity;Research Design;Research Personnel;research study;Resource-limited setting;Resources;Risk;Running;Sampling;sensor;Services;Side;signal processing;Signal Transduction;Smoking;Software Design;software development;Stream;Stress;Structure;synergism;System;technological innovation;Technology;technology research and development;Time;tool;Training;Translations;Trust;Universities;usability;wearable data;wearable device;wearable platform;wearable sensor technology;Work

PROJECT_TITLE: mDOT TR&D3 (Translation): Translation of Temporally Precise mHealth via Efficient and Embeddable Privacy-aware Biomarker Implementations


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: LUBBOCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

ORG_STATE: TX

PHR: Public Health Relevance Statement (Project Narrative) Chronic pain is a major health care issue, but mechanisms of the transition from acute to chronic pain still remain to be determined, particularly at the level of the brain. The proposed multidisciplinary research project addresses this important knowledge gap by identifying neuro-immune signaling in the amygdala, a brain center for emotions and pain modulation, as an important pain mechanism. Successful completion of the proposed studies will advance our knowledge about neuro-immune brain mechanisms of pain that can be targeted for pain management, which is highly significant from a basic science and clinical perspective hence translational.

PI_NAMEs: NEUGEBAUER, VOLKER  (contact);PONOMAREV, IGOR

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Acute Pain;Address;Affective;Amygdaloid structure;Anxiety;Area;Astrocytes;Basic Science;Behavior;Behavioral;Behavioral Assay;Binding;Bioinformatics;Brain;Cell Nucleus;cell type;Cells;Central Nervous System;Chronic;chronic neuropathic pain;chronic pain;Clinical;Complex;Corticotropin-Releasing Hormone;CRH gene;Development;Dimensions;Disease;Electrophysiology (science);Elements;Emotional;Emotions;Female;forced swim test;Funding;Genes;Genetic;Healthcare;Immunohistochemistry;improved;Individual;innovation;insight;interdisciplinary approach;Interdisciplinary Study;Knowledge;Label;Lateral;Ligation;male;Measures;Membrane;Mental Depression;Microglia;Modeling;Molecular;Molecular Biology;molecular marker;Molecular Profiling;Molecular Target;Neuroglia;Neuroimmune;Neuronal Plasticity;Neurons;neurotransmission;Nociception;novel;optogenetics;Outcome Measure;Output;Pain;pain behavior;pain chronification;Pain management;pain model;pain relief;painful neuropathy;patch clamp;Pathway interactions;peripheral pain;Persistent pain;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physiology;Play;Pontine structure;preference;Property;protein expression;public health relevance;Rattus;Regulation;Research Project Grants;Resolution;response;Role;Sensory;Sensory Thresholds;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Slice;Spinal;Spinal nerve structure;Spine pain;spontaneous pain;Sucrose;Synapses;Synaptic Transmission;System;Testing;Therapeutic;Time;tool;transcriptomics;Transgenic Organisms;United States National Institutes of Health;Viral;Viral Vector;vocalization;Work

PROJECT_TITLE: Amygdala pain mechanisms


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative/Relevance New technology that allows the classification of thousands of gut microbial features has made it possible to identify the many physiological and metabolic processes through which microbiota may influence the health of their hosts. Evidence from animal experiments and feeding studies has suggested that microbiota may modulate the risk of diabetes, although few prospective studies have been conducted to establish the relationship between gut microbiome and diabetes incidence. This study aims to examine microbiota composition, functional potential, and fecal metabolome in relation to the risk of developing diabetes in two well-established cohorts of U.S. men and women with complementary ethnic and socioeconomic backgrounds. Study findings will help identify novel microbial features as targets for developing individualized prevention and intervention strategies to alleviate the increasing societal and healthcare burden of diabetes.

PI_NAMEs: QI, QIBIN ;SUN, QI  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acceleration;Acids;Adult;Age;Amines;Animal Experiments;Animal Feed;Animals;Bacteria;Bile Acids;Bioinformatics;Biological Markers;biological research;Biometry;Branched-Chain Amino Acids;Butyrates;case control;Choline;Classification;Clinical;Coffee;cohort;Collaborations;college;cost;Cross-Sectional Studies;Data;Demographic Factors;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diet;dietary;Dietary Fiber;Effectiveness of Interventions;empowerment;Endocrine Glands;energy balance;Ensure;Enzymes;Epidemiology;Ethnic Origin;Etiology;experience;fecal metabolome;follow-up;frontier;fruits and vegetables;Gender;Gene Expression;Gene Family;Genes;Genetic Transcription;glucose metabolism;gut microbiome;gut microbiota;Health;healthcare burden;high risk;Hispanic Community Health Study/Study of Latinos;Human;improved;Incidence;individual variation;individualized prevention;Inflammation;Infrastructure;Institution;Intake;Intervention;Levocarnitine;Life Style;Link;Longitudinal Studies;Measures;Meat;Medical History;Medicine;men;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;microbiome;microbiome research;microbiota;microbiota composition;microbiota metabolites;multiple omics;mutualism;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;Nurses' Health Study;Oxides;Pathway Analysis;Pathway interactions;Pattern;personalized approach;personalized strategies;Pharmaceutical Preparations;Physical activity;Physiological Processes;Plants;Play;polyphenol;Population;Preparation;Prevalence;Prevention;Prevention strategy;Process;prospective;Prospective Studies;Public Health Schools;Qi;Race;Research;Research Design;Research Personnel;Resources;Risk;Role;Sample Size;Sampling;socioeconomics;stool sample;Taxonomy;Weight maintenance regimen;Woman

PROJECT_TITLE: Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

PHR: Project Lead: Shetty, Vivek Principal Investigator: Kumar, Santosh  mDOT – Technology Training & Dissemination (TT&D)  Public Health Relevance: mDOT will grow a new generation of transdisciplinary mHealth researchers who are  well-equipped to apply mDOT technologies and methods to discover, optimize, and deploy temporally-precise  mHealth interventions. Adoption of mDOT technologies will give rise to a new research paradigm and  transformatively improve health and disease outcomes by enabling patients to initiate and sustain the healthy  lifestyle choices necessary to prevent and/or successfully manage the growing burden of multiple chronic  conditions.  2

PI_NAMEs: SHETTY, VIVEK  (contact)

PROJECT_TERMS: Adoption;Articulation;Automation;Biological Markers;biopsychosocial;burden of chronic illness;Cellular Phone;Communities;Companions;Development;Disease Outcome;Disparity;Documentation;Educational workshop;Effectiveness;effectiveness evaluation;Evaluation;experience;Feedback;Generations;Goals;Health;Healthcare;healthy lifestyle;improved;Individual;Infrastructure;Institution;Intervention;Lead;Light;Link;Logic;Medical;Medicine;Mentorship;Methodology;Methods;mHealth;mhealth interventions;Modeling;multiple chronic conditions;Nature;open source;operation;Outcome;Output;outreach;Patients;Population Heterogeneity;prevent;Principal Investigator;Process;Professional Meetings and Conferences;Professional Organizations;programs;public health relevance;Publications;Research;Research Methodology;Research Personnel;Residencies;Resources;Robotics;Science;Scientist;sensor;Services;symposium;System;technological innovation;Technology;technology research and development;technology training;Technology Transfer;theories;tool;Touch sensation;Training;Training Activity;Translating;Translations;uptake;virtual delivery;visiting scholar;wearable device;web portal;web site

PROJECT_TITLE: mDOT Training and Dissemination


PHR: Project Narrative The goal of the project is to develop and clinically validate an ultrasensitive, selective, rapid, and simple HIV-1 viral load test that can be performed in point-of-care settings. Our integrated approach first separates viral particles from whole blood with a microfluidic filter, followed by capture and counting intact virions. Specific recognition of HIV is achieved through designer DNA “net” nanostructures that match the spatial pattern of envelope glycoprotein gp120 on the virus outer surface, where the DNA net is immobilized upon a photonic crystal biosensor surface, enabling a new form of microscopy that enhances viral light scattering intensity to count the captured HIV with digital precision. In contrast to nucleic acid tests that require sample pre-processing and enzymatic amplification, our direct approach is performed in a single step with no added reagents, yielding a result in less than 30 minutes.

PI_NAMEs: CUNNINGHAM, BRIAN T.;DEMIRCI, UTKAN  (contact);WANG, XING

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;Affinity;Antibodies;Antigens;antiretroviral therapy;aptamer;Avidity;Awareness;Base Sequence;Binding;Biological Assay;Biosensor;Blood;Buffers;Calibration;Chemistry;Clinical;clinically relevant;Collection;Complex;cost;Cytolysis;design;design,build,test;Detection;detection limit;Development;Device Designs;digital;DNA;Elements;Engineering;Environment;Epidemic;Epitopes;Exclusion;Experimental Designs;Exposure to;fabrication;Filtration;Glycoproteins;Goals;HIV;HIV Envelope Protein gp120;HIV-1;HIV/AIDS;Immobilization;Incidence;Individual;innovation;instrument;invention;Label;Laboratories;Lasers;light scattering;Measures;Mechanics;Microfluidic Microchips;Microfluidics;Microscopy;Monitor;Mother-to-child HIV transmission;nanoparticle;Nanostructures;Noise;Nucleic Acid Amplification Tests;Nucleic Acids;particle;Pathogen detection;Patients;Pattern;Performance;Persons;photonics;Plasma;point of care;point of care testing;Positioning Attribute;product development;Proteins;Protocols documentation;Reagent;Refrigeration;Reporting;Reproducibility;research and development;Resolution;Resource-limited setting;Reverse Transcriptase Polymerase Chain Reaction;Routine Diagnostic Tests;sample collection;Sampling;sensor;Serum;service utilization;Shapes;Signal Transduction;Site;Specificity;Specimen;Stains;stem;Surface;Surface Plasmon Resonance;System;Technology;Temperature;Testing;Time;tool;transmission process;Validation;Vertical Disease Transmission;Viral;Viral Genome;Viral load measurement;Viral Load result;Virion;Virus;Virus Integration;Whole Blood

PROJECT_TITLE: Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The objective of this K25 project is to combine a career development plan and research proposal to prepare the PI to become an independent investigator in human health risk assessment. The project focuses on integrating toxicological evidence from various sources to quantitatively characterize dose-response relationship (especially in the low-dose region) for liver carcinogenicity with non-mutagenic modes of action in support of chemical risk assessment to protect human health.

PI_NAMEs: SHAO, KAN  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: adverse outcome;Aryl Hydrocarbon Receptor;Award;Benchmarking;Biological;cancer risk;carcinogenicity;Carcinogens;career;career development;Chemical Exposure;Chemicals;Complement;cytotoxicity;Data;Development Plans;Dose;Environmental Health;Evaluation;Event;experience;Goals;Government;Guidelines;Health;Hepatocarcinogenesis;Human;improved;in vivo;Industry;innovation;Learning;Liver;Mediating;Mentors;Methodology;Methods;Modeling;Modernization;Mutagens;novel;Pathway interactions;PPAR alpha;Preventive Medicine;Publishing;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;response;Risk Assessment;Risk Estimate;Risk Management;Rodent;Science;Scientist;Series;Shapes;Source;success;Tetrachlorodibenzodioxin;tool;Toxic effect;Toxicology;Training;Training Programs;Uncertainty

PROJECT_TITLE: Quantitative dose-response characterization for liver carcinogenicity with non-mutagenic modes of action


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative As the prevalence of autism rises to unprecedented levels, the need to identify children who are at the greatest risk for developing this disorder is paramount to providing early intervention services in a timely way. In the current application we propose to collect high-dimensional EEG data in a large pediatric primary care clinic that disproportionately serves under-represented groups (95% Hispanic or African American), with the goal of being able to identify children in the first year of life who will subsequently develop autism by age 24 months.

PI_NAMEs: NELSON, CHARLES ALEXANDER (contact);TAGER-FLUSBERG, HELEN

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 2 year old;African American;Age;autism biomarker;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Behavioral;Biological Factors;Biological Markers;biomarker development;Black race;Boston;Brain;Child;Childhood;Clinic;Clinical;clinical application;Cognitive;Communities;comorbidity;Complex;Data;Data Collection;data-driven model;Development;Developmental Delay Disorders;developmental disease;Diagnosis;Diagnostic;Disease;Disparity;Disparity in diagnosis;disparity reduction;Early identification;Early Intervention;early life stress;Electroencephalography;Enrollment;Environmental Risk Factor;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Frequencies;functional outcomes;General Population;Genetic;global developmental delay;Goals;Health care facility;high dimensionality;High Prevalence;Hispanic;Hispanic Americans;Home;Household;improved;improved outcome;indexing;Individual;Infant;Intellectual functioning disability;Intervention;Judgment;Laboratories;Language;Life;Low income;low socioeconomic status;machine learning method;Maternal Health;maternal stress;Measures;Medical Records;Modeling;neural;Neurobiology;neuromechanism;Neuronal Plasticity;non-genetic;Outcome;Parental Ages;Pattern;Pediatric Hospitals;Population;Population Heterogeneity;predictive modeling;Predictive Value;prenatal;Prevalence;Primary Care;primary care clinic;primary care setting;Prospective Studies;Publishing;Questionnaires;Race;racial diversity;racial minority;racial population;Recording of previous events;Reporting;Research;Research Design;Resources;Rest;retention rate;Risk;Risk Factors;Sampling;screening;service intervention;Severities;sex;signal processing;Signs and Symptoms;socioeconomics;Source;Specificity;Stress;tool;Underrepresented Populations;usability;Well baby checks;Work

PROJECT_TITLE: Predicting ASD and Other Developmental Outcomes in the First Year of Life Using EEG in a Diverse Community-Based Sample

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: The University at Buffalo Clinical and Translational Science Institute (CTSI) is the coordinating center of the Buffalo Translational Consortium, which includes the region's premier research, educational and clinical institutions with influential community partners. The vision of the CTSI is to perform innovative clinical and translational research to reduce health disparities and improve the health of our community and the nation. We engage our community as research partners to create a shared environment to bring discoveries in the laboratory, clinic and community to benefit individual and public health.

PI_NAMEs: MURPHY, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Acceleration;Achievement;Address;Adopted;African American population;biomedical informatics;Center for Translational Science Activities;Cities;Clinic;Clinical;clinical center;clinical data repository;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Health;community partners;community partnership;County;Coupled;Cultural Backgrounds;Data;data integration;data sharing;Diverse Workforce;Education;education research;Environment;experience;Fostering;Foundations;Funding;Future;Genetic;Goals;Growth;Health;health disparity;Health Personnel;Health Professional;Health Sciences;Healthcare;Healthcare Systems;Heart;Image;image translation;Imaging technology;improved;Individual;Influentials;Informatics;informatics tool;innovation;Institution;interoperability;Knowledge;Laboratories;Learning;Life Expectancy;life span;Medical;Medical center;Medical Research;medical schools;Methods;multidisciplinary;multiple data sources;Natural Language Processing;New York;novel;novel strategies;Outcomes Research;Participant;Pediatric Hospitals;Persons;Phenotype;Population;Poverty;Process;Program Development;Prospective Studies;Public Health;Public Health Informatics;Recording of previous events;recruit;Recruitment Activity;Reduce health disparities;Refugees;Research;Research Institute;Research Personnel;Resources;response;Schools;Science;Sensitivity and Specificity;sharing platform;Site;skills;social health determinants;Special Population;Speed;Strategic Planning;structured data;System;Testing;tool;Training;translational impact;translational pipeline;Translational Research;translational scientist;Translations;Underrepresented Minority;Universities;unstructured data;Vision;Work;Workforce Development

PROJECT_TITLE: University of Buffalo Clinical and Translational Science Institute


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in African Americans with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.

PI_NAMEs: MILLS, KATHERINE TERESA (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Academy;Adherence;African American;African American population;aged;Albuminuria;Ambulatory Blood Pressure Monitoring;Aorta;Area;arterial stiffness;Behavior Therapy;biomarker validation;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Chronic Disease;Chronic Kidney Failure;Clinic Visits;Clinical;clinical risk;clinically significant;Cohort Studies;Control Groups;Diet;dietary;Dietary Sodium;Dietitian;Disease Outcome;EFRAC;endothelial dysfunction;Endothelium;Etiology;Event;Exclusion Criteria;Femur;Heart;Heart Atrium;high risk;Hour;Hypertension;Impairment;improved;Incidence;indexing;Intake;Intention;Intervention;Knowledge;Left;Left Ventricular Ejection Fraction;Left Ventricular Hypertrophy;Left Ventricular Mass;Measures;Mediating;Medicine;men;mortality;Observational Study;Organ;Outcome;Outcome Study;Participant;Patients;Physiologic pulse;Play;Potassium;primary outcome;Protocols documentation;Quality Control;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;renal damage;Reporting;Risk Factors;risk prediction;Role;secondary analysis;Side;Sodium;Standardization;State Medicine;Structure;targeted biomarker;Testing;Ventricular;Woman

PROJECT_TITLE: A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function in African Americans

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The purpose of the proposed study is to determine how two different immune cells, known as natural killer cells and T cells, work to recognize cancer cells and cause destruction of healthy tissues in patients receiving a bone marrow transplant. Understanding what stimulates these behaviors will help research scientists and physicians to make bone marrow transplants more successful at curing cancer.

PI_NAMEs: HSU, KATHARINE C (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute Myelocytic Leukemia;adaptive immune response;Affect;Algorithms;Alleles;Allogenic;Allografting;Antitumor Response;Behavior;Binding;Biological Models;Bone Marrow Transplantation;cancer cell;Cancer Etiology;Cause of Death;Cell Surface Receptors;Cells;Clinical;Clinical Research;cohort;curative treatments;Data;Data Scientist;Death Rate;dimorphism;Disease;disorder risk;Donor Selection;Education;Failure;Gene Combinations;Genetic;Genetic Polymorphism;Genotype;graft vs host disease;graft vs leukemia effect;Hematopoietic Stem Cell Transplantation;HLA-B Antigens;Immune;immune function;Immune system;Immunogenetics;Immunologist;In Vitro;in vivo;Incidence;Individual;Influentials;Innate Immune Response;leukemia;leukemia relapse;Ligands;Machine Learning;machine learning model;Malignant Neoplasms;Maps;Mediating;Modeling;Natural Killer Cells;NK cell receptor NKB1;novel strategies;Outcome;Patients;peptide B;Peptide Leader Sequences;Peptides;personalized medicine;Phenotype;Physicians;Population;Positioning Attribute;prevent;Process;receptor;Receptor Gene;Recurrent disease;Relapse;relapse prediction;Reproducibility;Research;response;Retrospective Studies;Risk;Scientist;Shapes;Statistical Models;T cell response;T-Lymphocyte;Time;Tissues;Training;Transplant Recipients;Transplantation;United States;Validation;Variant;Work

PROJECT_TITLE: Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Carcinoma invasion and metastasis is not only regulated in a cancer cell-autonomous fashion, but also through complex interactions with surrounding stroma cells as well as the surrounding interstitial matrix itself. Herein, we outline a series of novel in vivo and ex vivo models that support a pre-eminent role for the membrane- anchored matrix metalloproteinase, MT1-MMP, in regulating tumor cell progression by unexpectedly controlling a series of mechanotransduction-linked programs that directly impact the transcriptional programs underlying invasion and metastasis. These studies should not only shed new mechanistic insights on the key proteolytic events that regulate MT1-MMP-dependent control of cancer cell invasive and metastatic activities, but also help facilitate the identification of novel targets relevant to therapeutic intervention.

PI_NAMEs: WEISS, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3-Dimensional;Anabolism;Behavior Control;cancer cell;Cancer Control;Carcinoma;cell behavior;Cell Physiology;Cell Proliferation;cell stroma;Cell surface;Characteristics;Collagen Type I;Complex;conditional knockout;crosslink;Cytoplasm;Cytoskeleton;density;Deposition;Elements;Event;extracellular;Extracellular Matrix;Follow-Up Studies;Gene Expression;Genetic Transcription;Human;In Vitro;in vivo;insight;interstitial;Invaded;Knock-in Mouse;Knockout Mice;Laboratories;Lamin Type A;Link;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Matrix Metalloproteinases;mechanical properties;mechanotransduction;Membrane;membrane-type matrix metalloproteinase;Messenger RNA;MMP14 gene;Modeling;Molecular;Monitor;mouse model;MT2-MMP;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Nuclear Lamin;Nuclear Protein;Nucleoplasm;Outcome;Pathway interactions;Patient-derived xenograft models of breast cancer;Patients;Peptide Hydrolases;Play;Population;Process;programs;Progranulocytes;Proliferating;Publishing;Regulation;Reporting;Reticulum;RNA-Binding Proteins;Role;Series;Site;Structure;targeted treatment;Therapeutic Intervention;Tissues;Traction;trafficking;Transcription Coactivator;transcription factor PML;transcriptome;tumor progression;Xenograft procedure

PROJECT_TITLE: Function of Membrane Type Matrix Metalloproteinase

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative While sharing genomic data holds great promise for advancing biomedical research and personalized medicine, the uniqueness of the genomic data and the rich information they carry can put participants’ privacy at risk. In this project, we will develop practical solutions for genomic data sharing that provide data contributors with strong privacy assurance while enabling the release of high quality data. The outcome of the proposed research will encourage data contributors to participate in studies, widen the access to genomic data, and, in the long-term, facilitate genomic data-driven medical research to promote health and ease the burden of disease.

PI_NAMEs: BONOMI, LUCA  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Appointment;biomedical informatics;Biomedical Research;burden of illness;career;career development;Collaborations;Complement;Computational Biology;computer science;cryptography;Data;data access;Data Analytics;data anonymization;Data Collection;Data Correlations;data de-identification;data preservation;data privacy;Data Protection;Data Reporting;data sharing;Databases;design;Development Plans;Disclosure;Ensure;Equilibrium;Excision;experience;Eye;Faculty;flexibility;Gender;genetic variant;Genome;genome wide association study;genomic data;Genomic medicine;Genomics;Genotype;Goals;Hair Color;Health;Health Promotion;Human;improved;Individual;Institution;Knowledge;Medical Research;Methods;Mission;Modeling;National Human Genome Research Institute;Noise;Outcome;Participant;personalized medicine;Phase;Phenotype;Policies;precision medicine;prevent;Privacy;privacy preservation;privacy protection;Privatization;programs;Publications;Publishing;Records;Reproducibility;Research;Research Personnel;Risk;Sampling;skills;statistics;Techniques;Technology;Training Activity;Trust;Uncertainty;Universities;usability;Variant;Work;Y Chromosome

PROJECT_TITLE: SAFEGENOMES: Strong privacy Assurance For Effective GENOME Sharing

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The mechanisms of replicative lifespan of hematopoietic stem cells (HSC) are poorly understood. The functional decline of HSC through division is thought to be a degenerative process caused by accumulated damage that leads to cellular dysfunction, tissue failure, and death. Evidence accumulating over the past decade has now proven that there is a measurable and successive division-dependent functional decline in hematopoietic. The studies proposed in this application will provide information on cellular factors that become deregulated in hematopoietic stem cells with cumulative division and cause functional decline of the hematopoietic tissue, and will identify conditions under which HSC can be maintain with full potential through divisions. This could be a first step towards designing treatments to attenuate/revert HSC functional decline and consequently to improve tissue homeostasis and tissue regeneration.

PI_NAMEs: FILIPPI, MARIE-DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Applications Grants;Attenuated;Automobile Driving;Biological Clocks;Blood;Blood Cells;Bone Marrow Transplantation;candidate validation;Cardiolipins;Cells;Cessation of life;Clinical;Coupled;Crista ampullaris;Data;daughter cell;Defect;Disease;Dysmyelopoietic Syndromes;Enzymes;Event;Failure;Frequencies;functional decline;Functional disorder;functional restoration;Genetic Models;Goals;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell self-renewal;Hematopoietic stem cells;hematopoietic tissue;Homeostasis;Human;Image;Immune;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Ineffective Hematopoiesis;Inner mitochondrial membrane;Intervention;knock-down;Knowledge;Life;life span;Link;Lipids;Measurable;Mediating;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Swelling;Modeling;Molecular;Multipotent Stem Cells;Mus;Myelogenous;Natural regeneration;novel;novel strategies;Pathway interactions;pharmacologic;Phospholipids;Physiological;prevent;Process;Production;Property;Proteins;Quality Control;Recording of previous events;regeneration potential;regenerative;Regenerative capacity;Reporter;Reporting;Research;Risk;Role;self renewing cell;self-renewal;Shapes;small hairpin RNA;Stem Cell Assay;stem cell division;stem cell function;Stress;Structural defect;Supplementation;Testing;Tetracyclines;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapy design;tissue regeneration;Tissues;Transacylase

PROJECT_TITLE: The role of mitochondria in hematopoietic stem cell self-renewal

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Genetics

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Primary cilia are microtubule-based projections on virtually every cell type and are linked to multiple signaling pathways. Among the best studied is Sonic hedgehog (Shh), which requires the cilium for signal transduction. Here we use a series of mouse models to genetically uncouple ciliogenesis and vertebrate Hh signaling, and in the process paint a clearer mechanistic picture of each. These proposed experiments have great potential to give us the fundamental knowledge we need to develop strategies to treat diseases related to abnormal cilia or Shh signaling.

PI_NAMEs: CASPARY, TAMARA J. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Base Pairing;cell type;Cilia;cilium biogenesis;Cilium Microtubule;Comprehension;Disease;Dissection;Engineering;experimental study;Family;Genetic;Genetic Screening;Guanosine Triphosphate Phosphohydrolases;hedgehog signal transduction;in vivo;Individual;interest;Knowledge;Link;Molecular Genetics;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;neurodevelopment;Organelles;Paint;Pathway interactions;Process;Proteins;Regulation;Resolution;Role;Scientist;Series;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;Structure;Variant;virtual

PROJECT_TITLE: Genetic Dissection of Signaling and Cilia


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Lung;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The acute respiratory distress syndrome (ARDS) remains a common and frequently fatal cause of acute respiratory failure in critically ill patients, with no specific preventative strategies or therapies available. The goal of this project is to identify and deepen our understanding of subtypes of ARDS that may respond differently to treatments, in order to tailor therapy to individual ARDS patients and thereby improve clinical outcomes from ARDS.

PI_NAMEs: CALFEE, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;biological heterogeneity;Biological Markers;Biology;Characteristics;Clinical;clinical care;clinical heterogeneity;Clinical Trials;Clinical Trials Network;cohort;Complex;Critical Care;Critical Illness;Data;Data Set;Death Rate;Disease;Environmental Exposure;Environmental Impact;Exhibits;Failure;Goals;Human;Human Biology;improved;Individual;individual patient;individualized medicine;Inflammatory;knowledge base;Lung;Medicine;Modeling;molecular phenotype;multidimensional data;novel;novel therapeutics;Outcome;Patients;personalized approach;personalized medicine;Pharmacotherapy;precision medicine;Precision therapeutics;Prevention strategy;Preventive therapy;programs;Randomized, Controlled Trials;Research;Respiratory Failure;Syndrome;tool;Translating;treatment response

PROJECT_TITLE: Precision Medicine in the Acute Respiratory Distress Syndrome


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE The research proposed here is aimed at observing the mechanism by which high strength magnetic fields cause dizziness in human beings. Our goal is to develop new MRI techniques for diagnosis and treatment of vestibular disorders, while also solving the problem of dizziness when humans undergo MRI with high strength magnetic fields.

PI_NAMEs: WARD, BRYAN KEVIN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;anatomic imaging;Anatomy;Animals;Asphyxia;aspirate;Atelectasis;Award;Biomedical Engineering;career;cellular transduction;Chinchilla (genus);Clinical;clinical practice;clinical training;Conscious;cost;cost effective;Curiosities;Data;Dedications;Development;Diagnosis;Disease;Dizziness;Edema;Endolymph;Environment;Ethics;experience;fluid flow;Functional disorder;Funding;Future;Goals;Grant;Hair Cells;Head;Head and neck structure;Head and Neck Surgery;Health;high resolution imaging;Human;human imaging;Image;imaging modality;Imaging Techniques;improved;in vivo;inner ear diseases;Inner Hair Cells;Interdisciplinary Study;K-Series Research Career Programs;Knowledge;Labyrinth;Liquid substance;magnetic field;Magnetic Resonance Imaging;Magnetism;Mammals;medical schools;membranous labyrinth;Meniere's Disease;Mentors;Methods;Movement;MRI Scans;Nausea;Nausea and Vomiting;Nervous System Disorder;Neurology;Noise;North America;novel;Otolaryngology;Otology;Participant;Pathologic Nystagmus;Pathology;Patients;Pattern;Performance;Phase;Physics;Physiological;Pneumonia;Positional Vertigo;Positioning Attribute;professor;programs;Prospective Studies;Protocols documentation;Publishing;Radiology Specialty;recruit;Research;Research Personnel;Resolution;responsible research conduct;risk minimization;Safety;Scanning;Signal Transduction;skills;Structure;Supination;Surface;Target Populations;Techniques;Technology;temporal measurement;Testing;Time;Training;Universities;vector;Vertigo;Vestibular Diseases;Vestibular inner ear;vestibular system;Vestibule;ward;Work

PROJECT_TITLE: HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative Therapies that lower apolipoprotein C3 (APOC3) levels are currently under investigation for triglyceride- lowering in humans with severely elevated triglyceride levels. If successful, our proposed studies would set the stage for a cardiovascular outcome clinical trial on APOC3 lowering as a novel strategy for preventing the increased cardiovascular disease risk in patients with T1DM and high APOC3 levels in APOB100 lipoproteins.

PI_NAMEs: HEINECKE, JAY W (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acceleration;Address;Age;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Apolipoproteins;Apolipoproteins B;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Binding;Blood;Blood Pressure;Body fat;Body mass index;Calibration;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Clinical Research;Clinical Trials;Collaborations;Complement;Complications of Diabetes Mellitus;Coronary Arteriosclerosis;Coronary artery;coronary artery calcium;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Endothelial Cells;Epidemiology;experimental study;follow-up;Genetic Complementation Test;Glucose;glycemic control;Hepatic;High Density Lipoprotein Cholesterol;High Density Lipoproteins;high risk;Human;Hyperglycemia;Hypertriglyceridemia;IDL lipoproteins;Impairment;Incidence;Inflammation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Investigation;ion mobility;Isotopes;LDL Cholesterol Lipoproteins;Lesion;Lipids;Lipolysis;Lipoproteins;Liver;Low-Density Lipoproteins;Metabolic;metabolic abnormality assessment;Metabolic Clearance Rate;Methods;mouse model;Mus;Myeloid Cells;non-diabetic;Normal Range;novel strategies;Outcome;particle;Pathogenesis;Pathway interactions;Patients;Persons;Plasma;premature;prevent;Production;prospective;Prospective Studies;Proteins;Proteomics;Research Design;Risk;Risk Factors;risk prediction;Sampling;Series;Serum;sex;Smooth Muscle Myocytes;stable isotope;Study Subject;Testing;therapeutic target;Triglycerides;Universities;Very low density lipoprotein;Washington;Work

PROJECT_TITLE: Apolipoprotein C3-loading of apolipoprotein B100 lipoproteins and cardiovascular disease in patients with type 1 diabetes


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Depression;Health Services;Mental Health;Palliative Care;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The overall goal of this research is to improve post-treatment recovery outcomes in head and neck cancer survivors and caregivers through the delivery of the dyadic survivorship needs assessment planning (SNAP) tool implemented into clinic workflow at the end of treatment. SNAP is a survivorship care planning care transition tool with the central purpose to automate and simplify care practices to improve receipt of recommended care in dyads. In this research, we will conduct a randomized controlled trial to test the effects of the SNAP system on caregiver burden, survivor symptom severity and healthcare utilization in dyads and concurrently identify key barriers and facilitators to disseminating the SNAP system to diverse cancer care settings.

PI_NAMEs: STERBA, KATHERINE REGAN (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Acceleration;Address;Adoption;Aftercare;Anxiety;arm;Behavior;cancer care;Cancer Center;Cancer Survivor;care coordination;care systems;Caregiver Burden;Caregivers;caregiving;Caring;Case Study;Clinic;Clinical;Communication;comparative efficacy;Data;Deglutition;depressive symptoms;design;Early Intervention;Educational Materials;Enteral Feeding;experience;Face;flexibility;follow-up;Future;Goals;Head and Neck Cancer;health care service utilization;health care settings;Health Personnel;Home;implementation study;improved;improved outcome;Infrastructure;interest;Intervention;Investments;Knowledge;Life;Link;Maps;Medical;Mental Depression;Methods;Monitor;Needs Assessment;novel;Outcome;Patients;Phase;Physical Function;Pilot Projects;Play;programs;psychologic;psychosocial outcome;Randomized, Controlled Trials;Recommendation;Recovery;reduce symptoms;rehabilitation service;Reporting;Research;Role;routine care;Rural;Self Efficacy;Self Management;Services;Severities;Site;skills;Social Functioning;Southeastern United States;Structure;Supportive care;Surveys;Survivors;survivorship;symptom management;Symptoms;System;Tablets;Technology;technology intervention;Testing;Time;tool;Toxic effect;treatment as usual;treatment effect;uptake;Visit;Well in self;wound care

PROJECT_TITLE: A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor-Caregiver Dyads

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Heart Disease;Immunotherapy

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: This research takes advantage of a rich body of independent funded research. It will permit Dr. Neilan to dedicate 25% effort to mentor clinical investigators to research independence. Dr. Neilan has already demonstrated a track record of mentorship based on limited effort and this support will increase that impact.

PI_NAMEs: NEILAN, TOMAS G (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Anthracycline;Area;atorvastatin;attenuation;Award;Biological Markers;Blood;cancer therapy;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiotoxicity;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;career;Charge;chemotherapy;Clinical;Clinical Investigator;Clinical Research;coronary fibrosis;Dedications;Development;Echocardiography;Educational process of instructing;Environment;experience;Faculty;Fatty acid glycerol esters;Fibrosis;Foundations;Funding;Future;General Hospitals;Goals;Grant;Heart failure;heart function;heart imaging;heart preservation;HIV;Image;Imaging Techniques;Immune checkpoint inhibitor;Immunosuppression;improved;Incidence;innovation;insight;Institution;International;Leadership;Left Ventricular Ejection Fraction;Magnetic Resonance;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Manuscripts;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);mid-career faculty;mortality;Multi-Institutional Clinical Trial;Myocardial;Myocarditis;novel;oncology program;Outcome;Outcomes Research;patient oriented research;Patient-Focused Outcomes;Patients;Peer Review;Peer Review Grants;Persons;PET/CT scan;Positioning Attribute;preservation;programs;Publications;Publishing;Radiology Specialty;Randomized;randomized trial;randomized, clinical trials;Registries;Research;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Risk;Risk Factors;risk stratification;Role;Serum;side effect;Site;skills;stem;Structure;synergism;Testing;Time;Toxic effect;Training;Training and Education;training opportunity;Training Programs;Translational Research;treatment and outcome;treatment effect;Treatment Failure;Troponin;United States National Institutes of Health

PROJECT_TITLE: Cardiovascular Diseases among Patients with Cancer and Patients living with HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Stroke

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Ischemic stroke is a public health crisis given its high incidence and associated morbidity and mortality. The proposed work seeks to resolve the diagnosis of cryptogenic stroke or stroke of undetermined source by using advanced computational techniques and novel data sources. Pinpointing the underlying cause of stroke may optimize clinical care, identify therapeutic targets for clinical trial research, and improve neurologic outcomes on a large scale.

PI_NAMEs: SHARMA, RICHA  (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acute;Address;Advisory Committees;Age;Algorithms;Appointment;Arteries;Aspirin;Atherosclerosis;Attention;Big Data;Biological;Biological Markers;Blood Vessels;career;Caring;Categories;Classification;Clinical;clinical care;clinical decision-making;Clinical Research;Clinical Trials;cohort;Competence;Computational algorithm;Computational Technique;Computer Models;Computerized Medical Record;Country;cryptogenic stroke;Data;Data Analyses;Data Science;Data Set;Data Sources;Decision Making;deep learning;design;Diagnosis;Diagnostic;Diagnostic tests;Electronic Health Record;Emergency Medicine;Etiology;Event;evidence base;feature selection;follow-up;Foundations;fundamental research;Funding;General Hospitals;Goals;Grant;Health;health record;Healthcare Systems;Hospital Administration;Hospitalization;Hospitals;improved;Incidence;Investigation;Ischemia;Ischemic Stroke;Knowledge;Laboratories;Laboratory Research;Lead;Maps;Massachusetts;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidimensional data;multiple omics;neuroimaging;Neurologic;Neurological outcome;Neurologist;Neurology;novel;novel therapeutics;optimal treatments;Outcome;Pathology;Patient Admission;patient oriented;Patient Selection;Patients;Physicians;Positioning Attribute;post stroke;prevent;Prevention Measures;Prevention strategy;Prevention therapy;Process;professor;programs;Proteomics;Public Health;Radiology Specialty;randomized, clinical trials;Recurrence;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Risk;Scientist;Secondary Prevention;Series;sex;skills;Source;Stroke;stroke patient;Stroke prevention;stroke risk;stroke therapy;structured data;Subgroup;Surveys;Techniques;Testing;Therapeutic;therapeutic target;Time;tool;Training;training opportunity;translational scientist;treatment as prevention;Treatment Efficacy;Uncertainty;United States;unstructured data;Veterans Health Administration;Work

PROJECT_TITLE: Classification of Stroke Etiology Using Advanced Computational Approaches


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The emergence of electronic health records exposes clinicians to massive amounts of information about the millions of patients who suffer from communication and swallowing disorders, yet most clinical scientists do not have the training or skill to apply meaning to the data toward improving patient care. The overarching mentorship goal of this proposal is to train early, patient-oriented communication and swallowing scientists in big data analyses, including computer machine learning approaches. The research project will uncover distinct patterns and severity of swallowing impairments in large groups of patients with high risk medical diagnoses, which will have high impact on patient care planning and identification of treatments that directly target these impairments for improved outcomes.

PI_NAMEs: MARTIN-HARRIS, BONNIE J (contact)

PROJECT_TERMS: Acceleration;Algorithms;Applied Skills;Area;Award;Barium swallow;Big Data;Big Data Methods;Bioinformatics;Biological;Biomedical Research;Biometry;career;career development;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical practice;clinically relevant;Communication;Communication impairment;computer science;computer scientist;Computer Vision Systems;computerized;Computerized Medical Record;Computers;Data;Data Analyses;data platform;data registry;data resource;Data Science;Data Scientist;Data Set;data warehouse;Deglutition;Deglutition Disorders;Dementia;Development;Diagnosis;digital;Disease;Economics;Electronic Health Record;Engineering;experimental study;Explosion;Funding;Geography;Goals;Grant;Head and Neck Cancer;Health;health assessment;Hearing;high risk;human error;Impairment;impression;improved;improved outcome;Individual;Instruction;Intervention;Laboratories;learning algorithm;Machine Learning;Medical;Medical Records;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Mission;Modernization;National Institute on Deafness and Other Communication Disorders;novel;Nutritional;Outcome;Parkinson Disease;Patient Care;Patient Care Planning;patient oriented;Patients;Pattern;Phenotype;Physiological;Productivity;programs;Publishing;Registries;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Sample Size;Science;Scientific Inquiry;Scientist;Secure;Severities;skills;Speech;Standardization;statistical learning;Statistical Models;Strategic Planning;Stroke;Techniques;Testing;theories;Training;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Data Science Applications in Communication andSwallowing Disorders


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative The lung is home to a wide variety of tissue resident cells including an increasingly complex cadre of immune cells that have important roles in the response to environmental insults and infections. Dysfunction of immune cells forms to the basis of many common lung diseases. This project will explore early responses of immune cells in lung injury and also newly discovered populations of hematopoietic cells in the lung to facilitate the discovery of new approaches to treat lung diseases.

PI_NAMEs: LOONEY, MARK ROBERTS (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adult;Amaze;Antibodies;Area;Attention;biobank;Biogenesis;Biology;Blood Platelets;Blood Transfusion;cell type;Cells;Collaborations;Complex;COVID-19 pandemic;Development;Disease;Environment;extracellular;Funding;Funding Mechanisms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Home;Homeostasis;Human;Immune;Immune response;Immune System Diseases;Immunity;Immunobiology;Infection;Injury;intravital imaging;Lung;Lung Diseases;lung injury;Megakaryocytes;Mission;Modeling;Molecular;Mus;National Heart, Lung, and Blood Institute;Natural Immunity;neutrophil;novel;novel strategies;Organ Transplantation;pathogen;Pathogenesis;Pathway interactions;Population;programs;response;Role;Solid;Sterility;Techniques;Testing;therapeutic development;therapeutic target;Tissues;Transplantation

PROJECT_TITLE: Immunobiology of the normal and injured lung


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative  Gastric cancer is the third most common cause of cancer-related death world-wide, causing more than 700,000 death each year. We plan to characterize the molecular function(s) of CDK1 in gastric carcinogenesis, in order to identify its biological, diagnostic, prognostic, and possibly therapeutic significance.

PI_NAMEs: EL-RIFAI, WAEL  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Affect;Binding;Biological;Biology;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer statistics;carcinogenesis;Carcinogens;CDC2 gene;Cell Cycle;Cell Death;Cell Death Induction;Cell Survival;Cells;Cessation of life;chemotherapeutic agent;chemotherapy;Cisplatin;clinically significant;design;Development;Diagnosis;Diagnostic;empowerment;Epigenetic Process;experience;Future;gastric carcinogenesis;gastric tumorigenesis;Genetic;Genetic Transcription;genotoxicity;Growth;Helicobacter Infections;Helicobacter pylori;Human;human tissue;improved;in vitro Model;Infection;Link;malignant stomach neoplasm;Mediating;Molecular;mouse model;Mus;neoplastic cell;NF-kappa B;novel;novel therapeutic intervention;Oncogenic;Oncology;Organoids;Outcome;overexpression;Pathology;Persons;pharmacologic;Phosphorylation;Play;Population;Positioning Attribute;Preventive;prognostic;Property;Refractory;refractory cancer;Reporting;Resistance;response;Risk Factors;Role;self-renewal;Signal Pathway;Signal Transduction;Stimulus;Stomach Carcinoma;Survival Rate;Technology;Therapeutic;Therapeutic Intervention;therapy resistant;Time;Tissue Sample;transcription factor;Transcriptional Regulation;transcriptional reprogramming;translational potential;translational study;United States;Work

PROJECT_TITLE: Molecular Functions of CDK1 in Gastric Tumorigenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed project will acquire high-spatial-resolution diffusion MRI to construct tractography atlases for mouse, rat, and rhesus macaque brains with unprecedented detail of brain circuit information. The constructed atlases will be further used to develop novel automated tractography pipelines and associated shape analysis and bundle analytics tools for animal studies to investigate white matter tracts in brain disorders.

PI_NAMEs: YEH, FANG-CHENG  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;analysis pipeline;analytical tool;Animal Model;animal resource;Animals;Atlases;Axon;Brain;Brain Diseases;Brain Mapping;brain pathway;brain tissue;Cells;Compensation;connectome;Data;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;experimental study;Fiber;Fluorescence Microscopy;Functional disorder;Goals;histological image;Histology;Image;Immunohistochemistry;in vivo;Injections;Label;Light;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Maps;meter;Methods;Microscopic;microscopic imaging;Microscopy;multidisciplinary;Mus;Nervous System Disorder;Neuroanatomy;Neurons;novel;Optics;Pathway Analysis;Pathway interactions;polarized light;Primates;Process;Protocols documentation;Rattus;reconstruction;repository;Resolution;Rhesus;Sampling;Scanning;shape analysis;Site;Specimen;Structure;Testing;Time;Tissues;tool;Tracer;tractography;ultra high resolution;Universities;Validation;white matter

PROJECT_TITLE: Ultra-high Resolution Structural Connectome Atlases of the Animal Brain and their Associated Toolbox

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE. The COVID-19 pandemic due to SARS-CoV-2 infection poses new challenges to the nearly 3 million persons with multiple sclerosis (PwMS) worldwide. The proposed study aims to address salient knowledge gaps in the clinical management of PwMS during the pandemic and its aftermath. First, we will examine the association between MS immune-modulating disease- modifying therapies and COVID-19 risk and severity. Second, we will examine the COVID-19 vaccine efficacy and safety in MS and association with MS outcomes. Third, we will examine the effect of the pandemic on personal social network and health outcomes in PwMS. To pursue these research questions, we will leverage existing collaborations across multiple academic MS centers and a large data warehouse of integrated claims and electronic health records data. Given the protracted COVID-19 pandemic, real-world evidence emerging from the proposed study will critically inform the clinical management of PwMS during the rapidly changing landscape of neurological care.

PI_NAMEs: XIA, ZONGQI  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Adverse reactions;Award;B-Lymphocytes;Caring;Clinic;Clinical Management;Clinical Research;clinically relevant;cohort;Collaborations;Complement;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevalence;COVID-19 risk;COVID-19 severity;COVID-19 vaccine;Data;Data Reporting;Data Set;data warehouse;Disease;Electronic Health Record;Enrollment;Exclusion;General Population;Health;Healthcare Systems;immunoregulation;Infrastructure;Interferon-beta;Knowledge;Length of Stay;Low Prevalence;Mission;multiple sclerosis patient;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Nervous System Physiology;Neurologic;Neurological disability;Neurological outcome;Outcome;pandemic disease;pandemic impact;Participant;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians;pre-pandemic;Publishing;reduce symptoms;Registries;Reporting;Research;Research Activity;Research Infrastructure;resilience;Rest;SARS-CoV-2 infection;Severities;social;Social Network;Surveys;Testing;Time;United States National Institutes of Health;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccine efficacy;vaccine safety;vaccine trial;Vaccinee;virtual;Work

PROJECT_TITLE: Real-world impact of the COVID-19 pandemic in people with multiple sclerosis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative  Balance while walking is essential for mobility, yet individuals with vestibular loss experience instability in gait and increased fall risk. Through computational and experimental approaches, this project aims to understand how the body enacts different strategies to retain stability while walking, and how the execution of these strategies is affected by vestibular loss. The results from this research will identify strategies to be emphasized in rehabilitation for individuals with vestibular disorders to enhance stability while walking and decrease fall risk.

PI_NAMEs: HARTER, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;Affect;Ankle;Biomechanics;Biomedical Engineering;Clinical assessments;Compensation;Complex;Computer Models;Data;Doctor's Degree;Engineering;Equilibrium;Excision;expectation;experience;experimental study;Fall prevention;fall risk;falls;foot;Gait;gait examination;Goals;high risk;Human;human model;improved;Individual;insight;Joints;kinematics;Knowledge;Lateral;Literature;Locomotion;Measures;Mentorship;Modeling;Motion;Motor;Movement;Musculoskeletal Equilibrium;National Institute on Deafness and Other Communication Disorders;neural;neurophysiology;Pattern;Performance;Persons;physical therapist;Physicians;Population;Posture;programs;Publications;rehabilitation strategy;Rehabilitation therapy;Research;research study;Risk;Robotics;Role;Sensory;skills;Statistical Data Interpretation;System;Technology;Testing;Torque;Vestibular Diseases;Vestibular loss;vestibular system;Walking;Work

PROJECT_TITLE: Computational Modeling of Stability in Locomotion and the Effects of Vestibular Loss


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Childhood Obesity;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE American Indian youth have the highest prevalence of obesity of all ethnic groups in the United States. Health behaviors can modify obesity risk and associated morbidity. The goal is to develop and test community-led, family-focused and culturally-responsive intervention that supports American Indian youth in achieving healthy lifestyle behavior change.

PI_NAMEs: HINGLE, MELANIE DANIELA (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Adolescent;adolescent health;Adopted;Adoption;adult obesity;adverse childhood events;aged;American Indian community;American Indians;Apache Tribe;Attention;Behavior;behavior change;Body mass index;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Caregivers;Child;Child Rearing;Chronic Disease;Communities;Community Actions;community collaboration;community led intervention;Consumption;Coping Skills;cost;culturally appropriate intervention;design;Diabetes Mellitus;disorder prevention;Ensure;Equilibrium;ethnic disparity;Ethnic Population;Faculty;Family;Family Relationship;fasting glucose;Foundations;fruits and vegetables;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;Healthy Eating;healthy lifestyle;High Prevalence;Home;Home environment;Hypertension;improved;Individual;Intake;Intervention;intervention delivery;Intervention Studies;Knowledge acquisition;Life;Life Cycle Stages;Lipids;Malignant Neoplasms;Measures;Mental Health;Metabolic Diseases;Mind-Body Intervention;Modeling;Morbid Obesity;Morbidity - disease rate;novel;Obesity;obesity prevention;obesity risk;Outcome;Parents;Participant;Pascua Yaqui;Persons;Physical activity;post intervention;Poverty;preventive intervention;primary outcome;programs;Pueblo Race;racial disparity;Research;Risk;Risk Factors;Risk Reduction;Schools;secondary outcome;skills;skills training;social determinants;socioeconomic disparity;Sodium Chloride;Specificity;Strenuous Exercise;Stress;Stroke;success;Testing;Time;Trauma;tribal community;tribal Nation;Tribes;Trust;United States;Weight;Well in self;Work;Yavapai;Youth

PROJECT_TITLE: Achieving American Indian Youth Energy and Mental Health Balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(51)R]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Neurosciences;Precision Medicine;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Glioma immunoediting is a process by which tumor cells capable of avoiding immune recognition are selected by anti-tumor immunity. This proposal focuses on MAPK as a target of glioma immunoediting by CD8 T-cells, investigating how this signaling in tumor cells influences the microenvironment, and predict response to immunotherapy in gliomas.

PI_NAMEs: SONABEND, ADAM M (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: blood-brain barrier crossing;BRAF gene;cancer infiltrating T cells;CAR T cell therapy;Cd68;CD8-Positive T-Lymphocytes;Cell Line;Cells;Characteristics;chemokine;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Engraftment;Exhibits;Flow Cytometry;Gene Expression;Genetic;genetic approach;Glioblastoma;Glioma;glioma cell line;Human;Image;Immune;Immunocompetent;immunogenic;Immunohistochemistry;Immunotherapy;Implant;Infiltration;Inflammatory;ITGAM gene;Knock-out;Knockout Mice;Macrophage;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Microglia;Modeling;Molecular;Mus;Mutation;Neoplasm Transplantation;neoplastic cell;novel;p38 Mitogen Activated Protein Kinase;Pathway interactions;patient response;patient subsets;Patients;PD-1 blockade;Pharmaceutical Preparations;Phenotype;Phosphorylation;Platelet-Derived Growth Factor;predicting response;Predisposition;Process;programmed cell death protein 1;PTPN11 gene;randomized trial;Recurrence;Reporting;Resistance;response;Role;Signal Transduction;Specimen;Stains;T cell response;T-Cell Depletion;T-Lymphocyte;Therapeutic;Transgenic Mice;Transgenic Model;Transplantation;tumor;Tumor Immunity;tumor progression;Tumor-associated macrophages;Up-Regulation

PROJECT_TITLE: MAPK as target of glioma immunoediting by CD8 T-cells, and predictor of response to immunotherapy


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The Vision Science Society (VSS) organizes an annual meeting for presenting cutting edge research on the mechanisms and principles of normal and abnormal visual perception. The aging American population will experience an increasing rate of visual loss due to diseases and disorders of the eye and central visual pathway. Understanding the perceptual sequalae of and developing effective therapies for visual disorders requires knowledge in the diverse research domains sponsored by the annual meeting of VSS.

PI_NAMEs: BOYNTON, GEOFFREY M (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Address;Aging;American;Area;Attention;Award;Basic Science;Binocular Vision;Blindness;career;career development;Clinical;Clinical Research Associate;Coffee;Cognitive Science;Color;Communication;Computer Models;Computer Vision Systems;cost;design;Development;Discipline;Disease;early-career faculty;Educational workshop;effective therapy;Event;Exhibits;experience;Exposure to;Eye diseases;Eye Movements;Face;face perception;Faculty;Feedback;Female;Florida;Funding;Future;Goals;Government;graduate student;Grant;Health;Hour;Human;Individual;Industry;Institution;interest;Island;Journals;Knowledge;Lesbian Gay Bisexual Transgender Queer;Light;mathematical model;Medal;Mediation;meetings;member;Mentors;Modernization;Motion Perception;multisensory;Music;National Eye Institute;Nature;neuroimaging;next generation;object recognition;Occupations;Ophthalmology;Participant;peer;Perception;Perceptual learning;perceptual organization;Population;Postdoctoral Fellow;posters;pre-doctoral;Principal Investigator;Productivity;professor;programs;Psychophysics;Publishing;Qualifying;Research;Research Personnel;Resort;Review Committee;Science;science and society;Scientist;Series;social;spatial vision;student conference;Students;success;symposium;Time;Training;Travel;undergraduate student;United States;United States National Institutes of Health;Vendor;Vision;Vision Disorders;vision science;visual coding;visual cognition;visual control;Visual Illusions;visual memory;visual neuroscience;Visual Pathways;Visual Perception;visual processing;Visual Psychophysics;visual search;Work

PROJECT_TITLE: Annual meeting of the Vision Sciences Society: Travel grants for junior investigators


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Exercise is an effective intervention for both the prevention and treatment of heart and metabolic diseases, though there are substantial differences in how any given individual responds. Our goal is to better understand the fundamental mechanisms by which exercise confers its beneficial effects and in doing so determine which individuals benefit most from regular exercise.

PI_NAMEs: GERSZTEN, ROBERT E (contact);SARZYNSKI, MARK ANDREW

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Adult;Aerobic Exercise;Affect;African American;Age;Alanine-glyoxylate aminotransferase;Biochemical;Biochemical Pathway;Biological;Biological Markers;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder prevention;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;caucasian American;Clinical;clinical biomarkers;cohort;Data;Data Set;Development;Diabetes Mellitus;Disease;early detection biomarkers;effective intervention;endurance exercise;Enzymes;Exercise;exercise intensity;exercise intervention;exercise program;exercise regimen;exercise training;family genetics;Family Study;Fatty acid glycerol esters;Female;Future;Genetic;Genetic Determinism;Genome;genome resource;genomic locus;Goals;Guidelines;Health;Heart Diseases;High Density Lipoprotein Cholesterol;improved;Individual;Individual Differences;insight;insulin sensitivity;interest;Investigation;Jackson Heart Study;Lipids;Liver;member;Mendelian randomization;Meta-Analysis;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;metabolomics;Methods;Molecular;Molecular Profiling;n-pentanoic acid;novel;Outcome;Participant;Pathway interactions;Phenotype;Physical activity;Plasma;Population;population based;prevent;Prevention;Primary Prevention;Proteins;Proteomics;Protocols documentation;Resources;response;Risk Factors;sedentary;sex;Standardization;Testing;Training Programs;trait;Transducers;United States National Institutes of Health;Visceral fat;VO2max

PROJECT_TITLE: Biochemical profiling to identify cardiometabolic responsiveness to an endurance exercise intervention

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative The development of vaccines against common respiratory viruses, such as RSV, remains challenging. Polyvalent mRNA-lipid-nanoparticle vaccines offer a potential solution. Here we propose test the effect polyvalent RSV vaccines have on adaptive immune response.

PI_NAMEs: ANDERSON, CHRISTOPHER S (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: adaptive immune response;Antibodies;Antibody Response;Antibody Specificity;antibody test;Antibody titer measurement;Antigens;B-Lymphocytes;Binding;Biological Assay;Blood group antigen f;Body Weight decreased;Cells;Cessation of life;Child;Clinical Trials;Codon Nucleotides;Computer Assisted;computer framework;Computer Models;Computer Simulation;cross reactivity;Development;Disease;Elderly;Encapsulated;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Evaluation;Failure;Formulation;Hospitalization;Human;Humoral Immunities;Immune;Immune response;Immunity;Immunization;Immunize;Immunology;improved;In Vitro;Infection;insight;Lipids;Lung;lung histology;Membrane Proteins;Messenger RNA;Monitor;mouse model;mRNA lipid nano particle vaccine;Mus;neutralizing antibody;Outcome;pathogen;Polyvalent Vaccine;Proteins;pulmonary function;Recording of previous events;Respiratory syncytial virus;Respiratory Syncytial Virus Vaccines;respiratory virus;Severity of illness;simulation;Site;Specificity;Structure;T-Lymphocyte;Testing;Time;Vaccine Design;vaccine development;vaccine formulation;Vaccines;Variant;Viral load measurement;Viral Proteins;Virus;Virus Diseases;virus host interaction

PROJECT_TITLE: Development and testing of RSV vaccines using a computational framework of virus-host interaction

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


PHR: Project Narrative Phosphatidylserine is a lipid whose exposure to blood promotes clotting. This proposal uses animal models and state-of-the-art microscopy techniques to study how endothelial cells on the blood vessel wall contribute phosphatidylserine to generate thrombosis. By studying the regulation of phosphatidylserine exposure on endothelial cells, we will gain a better understanding of how blood clots form in vessels, which may allow for the development of novel therapeutics to treat thrombotic disease.

PI_NAMEs: SCHMAIER, ALEC ANDREW (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Address;Advisory Committees;Affect;Animal Model;Animals;Apoptosis;Binding Proteins;Biological;Biology;Bleeding time procedure;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Bone Diseases;Calcium;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell membrane;Cell surface;Cells;Cellular biology;Childhood;Coagulation Process;cofactor;Data;defined contribution;Development;endothelial cell procoagulant activity;Endothelial Cells;Endothelium;Environment;Enzymes;Exposure to;factor IXa-factor VIIIa;Family;Family member;ferric chloride;Fibrin;Functional disorder;Generations;Goals;Hemostatic function;human disease;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;inhibitor;Injury;innovation;intravital microscopy;Investigation;Israel;Kinetics;Knockout Mice;Laser injury;Lasers;Lipids;loss of function mutation;Medical;Medical center;Medicine;Membrane;Mentors;Mentorship;Microscopy;Modeling;mouse model;Multienzyme Complexes;Muscular Dystrophies;Mutation;Myocardial Infarction;novel;novel therapeutics;Outcome;paralogous gene;Participant;Pathologic;Pennsylvania;Phosphatidylserines;phospholipid scramblase;Phospholipids;Physicians;Physiological;Platelet Activation;Positioning Attribute;Process;Reaction;Regulation;Research;Research Personnel;Research Training;Role;Scientist;Site;Skeletal Muscle;skills;Source;Stroke;Surface;Techniques;Testing;Thromboplastin;Thrombosis;thrombotic;Thrombus;Training Programs;Universities;Vascular Endothelium;venous thromboembolism;Work

PROJECT_TITLE: Regulation of endothelial cell phosphatidylserine in thrombosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

PHR: PROJECT NARRATIVE Pain is a significant problem affecting millions of people per year with limited therapeutic options. To address this issue, we have proposed to identify mechanisms underlying redistribution of voltage gated Na+ channels in peripheral axons following trigeminal nerve injury. The results of these studies may suggest novel therapeutic targets for the treatment of neuropathic pain.

PI_NAMEs: GEDEON, JEREMY  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Accounting;Action Potentials;Acute;Address;Affect;Afferent Neurons;Anatomy;Anisomycin;antinociception;Attenuated;Axon;Behavior;Behavioral;Biochemical;career;chronic constriction injury;chronic pain;Colchicine;collaborative environment;comparative;Consensus;constriction;Data;density;disability;Electrophysiology (science);Ensure;experimental study;Face;Future;Goals;Hypersensitivity;Image;Immunohistochemistry;in vivo;inhibitor;Injury;Ligation;Literature;mechanical stimulus;Mechanics;Messenger RNA;Microtubules;Modeling;mRNA Translation;Nerve;nerve injury;neuronal cell body;Neurons;Neurosciences;new therapeutic target;Nociception;novel therapeutic intervention;Pain;pain behavior;painful neuropathy;Peripheral;Peripheral nerve injury;Peripheral Nerves;Persistent pain;Persons;pharmacologic;preference;Prevalence;prevent;Protein Synthesis Inhibitors;protein transport;Proteins;Research Personnel;response;response to injury;Science;SCN1A protein;Series;Site;Sodium Channel;Stimulus;Structure of trigeminal ganglion;success;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;trafficking;Training;Translations;Trigeminal nerve structure;Trigeminal System;Universities;Up-Regulation;Visualization;voltage;Western Blotting;Work

PROJECT_TITLE: Contribution of Local Translation to Nerve Injury-Induced Upregulation of Nav1.1 in Trigeminal Nerves