NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Primary Health Care;Women's Health Research

PHR: PROJECT 1: NARRATIVE Our ongoing WISDOM clinical trial is among the first attempts to try a new approach to breast cancer screening in which each woman receives a personalized screening and prevention recommendation based on her individual risk of breast cancer. Since we began in 2016, we have learned how to better estimate a woman’s breast cancer risk and we can now begin to determine whether a woman is at risk for fast-growing cancers or slow-growing cancers. In this research project, we will investigate if more intense screening for women who are high-risk for fast-growing cancers will help detect them earlier when they are more treatable, while also offering women who are at high risk of slow-growing cancers an opportunity to begin risk-reducing therapy that has already proven to be effective for breast cancer prevention, and reduce the burden of screening for average risk.

PI_NAMEs: ESSERMAN, LAURA J (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;Adopted;Advanced Malignant Neoplasm;Advocate;Age;Artificial Intelligence;artificial intelligence algorithm;Biopsy;Biotechnology;Breast;Breast Cancer Detection;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Factor;breast surgery;Cancer Intervention and Surveillance Modeling Network;cancer subtypes;Categories;Classification;clinical material;Clinical Trials;cohort;Collaborations;Communities;comparative effectiveness trial;Computational Biology;Data;Detection;Development;Diagnosis;education resources;Effectiveness;Endocrine;Enrollment;Epidemiology;experience;Failure;Family;Frequencies;Germ Lines;Goals;Guidelines;Health system;Healthcare;Heterogeneity;high risk;high risk population;High Risk Woman;Hormones;Image;imaging modality;improved;Incidence;Individual;individualized prevention;Infrastructure;Insurance Carriers;Intervention;Leadership;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Medical Oncology;Modality;Modeling;Molecular Biology;Morbidity - disease rate;mortality;multidisciplinary;Mutation;new technology;novel;novel strategies;Outcome;outreach;Participant;Pathogenicity;Pathology;Patient Care;Patient Compliance;patient retention;personalized screening;Policy Maker;polygenic risk score;Population;Prevention;preventive intervention;Primary Care;programs;Prospective Studies;Radiology Specialty;Randomized;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Risk Reduction;routine screening;screening;Screening for cancer;screening guidelines;Seasons;Specialist;Time;tool;tumor;Tumor Biology;tumor growth;Tumor Subtype;United States;uptake;Variant;Woman;Work

PROJECT_TITLE: Project 1: Implementing Risk-based Tools that Incorporate Tumor Biology to Optimize Screening and Prevention


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Burden of Illness;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT 4: NARRATIVE Mammography screening currently misses many fast-growing breast cancers. The goal of Project 4 is to use a model to define the group of women at risk for fast growing tumors who would benefit from more intensive screening for breast cancer and to define the group of women at risk for the slow growing tumors who would benefit from medicines to prevent breast cancer. The ultimate goal is to decrease death from breast cancer in the United States.

PI_NAMEs: TICE, JEFFREY A (contact)

PROJECT_TERMS: Age;Assessment tool;Breast Cancer Detection;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Assessment Tool;breast density;Breast Magnetic Resonance Imaging;Cancer Intervention and Surveillance Modeling Network;cancer subtypes;Cessation of life;Clinical;comorbidity;comparative;Complement;cost;cost comparison;cost effectiveness;cost estimate;Data;Data Sources;Development;Diagnosis;Digital Mammography;Eligibility Determination;Family;Feedback;Funding;future implementation;Genes;Goals;Grant;Guidelines;High Risk Woman;hormone therapy;Incidence;Life Expectancy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medicine;Modeling;models and simulation;Morbidity - disease rate;mortality;multidisciplinary;Natural History;Obesity;Outcome;personalized screening;Population;predictive tools;Prevention;Quality of life;Quality-Adjusted Life Years;Race;randomized trial;Recommendation;Recording of previous events;Risk;Risk Assessment;Risk Factors;risk prediction;routine screening;screening;screening guidelines;Series;Single Nucleotide Polymorphism;Subgroup;tomosynthesis;trial comparing;tumor;tumor growth;United States;United States Preventative Services Task Force;Update;Woman;Women's Group

PROJECT_TITLE: Project 4: CISNET Modeling of outcomes and cost for risk-based screening strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (M1)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Cost Effectiveness Research;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

PHR: CORE B: PROJECT NARRATIVE The primary goal of Core B (Biostatistics and Bioinformatics) is to collaborate with the P01 Investigators and other Core resource scientists to ensure that research conducted within this P01 program adheres to the highest standards of quality, rigor, and reproducibility. It will serve as a centralized resource for comprehensive analytic, computational, and data management support necessary for the success of individual projects and the P01 as a whole.

PI_NAMEs: KIM, MI-OK  (contact)

PROJECT_TERMS: Administrative Efficiency;Artificial Intelligence;artificial intelligence model;Bioinformatics;Biometry;Breast Cancer Detection;Breast Cancer Risk Factor;Cancer Biology;Cancer Intervention and Surveillance Modeling Network;Clinical;cloud based;cloud platform;Code;Collaborations;computer infrastructure;Consultations;Cost Analysis;cost effectiveness;Data;data access;Data Analyses;Data Collection;data integration;data management;Data Management Resources;data privacy;Data Science;data sharing;Data Sources;Data Storage and Retrieval;deep learning;design;Development;Dimensions;diverse data;Documentation;Enrollment;Ensure;Environment;experience;Genomics;Goals;Grant;high standard;Human Resources;implementation science;Individual;Infrastructure;innovation;Machine Learning;Maintenance;Malignant Breast Neoplasm;Mammography;Modeling;Nature;novel;Outcome;Participant;Patient Outcomes Assessments;Performance;Phase;polygenic risk score;Population;precision medicine;Prevention;Prevention Research;Process;Production;Program Research Project Grants;programs;Recording of previous events;Reporting;repository;repository infrastructure;Reproducibility;Research;Research Design;Research Personnel;Resources;Risk;Risk Assessment;Risk Marker;risk prediction;Risk Reduction;routine screening;Scientist;screening;Secure;Security;Shapes;simulation;Source;success;System;Systems Biology;Training;tumor;United States National Institutes of Health;Update

PROJECT_TITLE: Core B: Biostatistics and Bioinformatics


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

PHR: CORE C: NARRATIVE Core C will be responsible for supporting all the genetics work in each of the Projects. The work will include data cleaning and imputation (Projects 1-3), genetic ancestry estimation, calculation of polygenic risk scores for Projects 1 and 3 for overall breast cancer and for breast cancer subtypes. Core C will also and support Project 4 by providing risk distributions based on polygenic risk scores across different ancestry populations.

PI_NAMEs: ZIV, ELAD  (contact)

PROJECT_TERMS: African ancestry;Breast Cancer Detection;Breast Cancer gene;Breast Cancer Model;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;cancer subtypes;Cancer-Predisposing Gene;Clinical Research;cohort;Collaborations;Communication;Data;data cleaning;data imputation;Data Set;Disease;disease-causing mutation;disorder risk;Ensure;Epidemiology;Estrogen receptor negative;Estrogen receptor positive;Ethnic Origin;Ethnic Population;Family;Fasting;Foundations;Frequencies;Genes;Genetic;Genetic Risk;genetic risk assessment;genetic variant;genome sequencing;genome wide association study;Genomics;Genotype;Goals;high risk;improved;Joints;Latina Population;Learning;Malignant Breast Neoplasm;Mammographic Density;Modeling;molecular phenotype;next generation;non-genetic;Outcome;Participant;Pathogenicity;Penetrance;polygenic risk score;Population;Population Heterogeneity;Predisposition;Prevention;prospective;Race;Recording of previous events;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;screening;Update;Variant;whole genome;Woman;Work

PROJECT_TITLE: Core C : Population Genomic Risk Assessment


ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE – OVERALL Due to the exponential rise in non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma (HCC), a cancer that is refractory to many treatment options, is rapidly becoming a leading cause of cancer mortality. We hypothesize that HCC initiation and malignant progression is triggered by altered lipid/cholesterol metabolism, with consequent oxidative and endoplasmic reticulum stress, activation of the unfolded protein response, that accentuate mitochondrial dysfunction leading to hepatocyte senescence allowing accumulation of genetic mutations that allow outgrowth of transformed hepatocytes. This P01 will investigate interacting pathogenic pathways, operating in different cellular compartments- cytosol, nucleus, ER, and mitochondria- that generate a vicious downward spiral responsible for NASH to HCC progression, paving the way for developing novel diagnostics and therapies.

PI_NAMEs: KAUFMAN, RANDAL J. (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Ablation;Acceleration;Address;ATF6 gene;Attenuated;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Bioinformatics;Biological Markers;Biometry;Cancer Etiology;cancer stem cell;cancer survival;career;Cell Communication;Cell Nucleus;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Chronic;Chronic viral hepatitis;Collaborations;Communication;Computational Biology;Cues;Cytosol;Data;Data Collection;data resource;Development;Diet;dietary;DNA Damage;DNA Sequence Alteration;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Etiology;experience;Foundations;Gene Expression;Genomics;Glucose;glucose metabolism;Glycolysis;Hepatocyte;Human;human data;Hydrophobicity;Individual;Induced Mutation;Inflammation;insight;Intervention;Isotopes;Lead;Lesion;lipid metabolism;Lipids;Malignant - descriptor;Malignant Neoplasms;Mediator;Medical;meetings;Membrane;Membrane Proteins;Metabolic;Metabolic stress;Metabolic syndrome;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Molecular;mortality;mouse model;mRNA Expression;Mus;Mutagenesis;Mutation;new technology;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel diagnostics;novel therapeutics;Nuclear;Nutrient;Nutritional;Obesity Epidemic;Outer Mitochondrial Membrane;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;prevent;Prevention;Preventive;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Production;Productivity;progenitor;programs;Proliferating;Protein Binding Domain;protein misfolding;Proteins;Proto-Oncogene Proteins c-akt;Refractory;Reporting;Repression;Reproducibility;Research Personnel;Resources;response;Role;senescence;SH3 Domains;Somatic Mutation;Specimen;steroidogenic acute regulatory protein;Stress;success;Suggestion;Testing;Therapeutic;Therapeutic Intervention;TP53 gene;Transducers;Transgenic Mice;translational potential;web site

PROJECT_TITLE: Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

PHR: PROJECT NARRATIVE – CORE A: ADMINISTRATIVE The Administrative Core A will provide necessary management to this Program Project by serving as the nexus for communication and coordination of all joint activities between individual Projects, Cores, the Internal and External Advisory Boards and the NCI. The Program seeks to address NCI public health goals by addressing an unmet need in HCC research, which will be supported by Core A by disseminating research results to the health care community. With Core 2, Core A will oversee maintenance of the website and dissemination of results including data exchange. Core A with the Steering Committee will be responsible for evaluating productivity, coordinating efforts, allocating resources, and resolving any conflicts that arise.

PROJECT_TERMS: Address;Bioinformatics;Biometry;Budgets;Collaborations;Communication;Communities;Conflict (Psychology);Core Facility;Data;data acquisition;Data Collection;data exchange;design;Documentation;Electronics;Ensure;Evaluation;Experimental Models;Fostering;General Population;Genomics;Guidelines;health goals;healthcare community;IACUC;Individual;Information Dissemination;Institution;Internet;Joints;Leadership;Logistics;Maintenance;Medical;meetings;member;Metabolic stress;Monitor;nonalcoholic steatohepatitis;operation;Participant;Persons;Preparation;Primary carcinoma of the liver cells;Process;Productivity;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Public Health;Publications;Published Comment;Reagent;Reporting;Reproducibility;Research;Research Personnel;Resolution;Resource Allocation;Resources;Role;Scientist;Series;Site;Structure;symposium;synergism;tool;United States National Institutes of Health;virtual;web site;Work;working group;Writing

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE - PROJECT 1 Project 1 will study the role of the recently discovered NRF2-FBP1 crossregulatory interactions in the progression from NASH-associated hepatocyte senescence to frank hepatocellular carcinoma (HCC). We will investigate the mechanisms by which stressed senescent hepatocytes downregulate FBP1 and TP53 to activate NRF2 and gain malignant potential and whether this switch directly occurs within the senescent cell, as well as the role of hepatocyte DNA damage in this process.

PI_NAMEs: KARIN, MICHAEL  (contact)

PROJECT_TERMS: Ablation;Acceleration;Address;AKT inhibition;Apical;ATF6 gene;Autophagocytosis;CDKN2A gene;Cells;Cholesterol;Consumption;Detection;Development;Diet;Disease;DNA;DNA Damage;DNA Sequence Alteration;DNA sequencing;Down-Regulation;EGF gene;endoplasmic reticulum stress;Enzymes;Equilibrium;experimental study;Family member;Fatty acid glycerol esters;Fatty Acids;feeding;Frequencies;Fructose;Genetic Transcription;Gluconeogenesis;Gluconeogenesis Inhibition;Glycogen;Grant;Hepatic;Hepatocyte;Hexosamines;Human;human disease;inhibitor;Injections;Insulin Resistance;Liver;Malignant - descriptor;MAPK3 gene;Metabolic;Metabolic stress;Metabolism;Mus;Mutagenesis;Mutation;nonalcoholic steatohepatitis;novel;Nucleotides;Oncogenic;Oxidative Stress;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Primary carcinoma of the liver cells;Process;progenitor;programs;Proteomics;Proto-Oncogene Proteins c-akt;response;restraint;Risk;RNA;Role;senescence;senescent cell;sensor;single cell sequencing;single-cell RNA sequencing;Specimen;stem cells;Stress;System;TP53 gene;transcription factor;Transplantation;tumor;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin

PROJECT_TITLE: Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Rare Diseases

PHR: PROJECT NARRATIVE -PROJECT 2 The incidence of hepatocellular carcinoma (HCC) will continue to rise due to the global increase in obesity and the rapid change in etiology toward metabolic drivers. Project 2 focuses on the contribution of the endoplasmic reticulum (ER) and the unfolded protein response (UPR) transducer ATF6, which releases a soluble active transcription factor (ATF6p50). We hypothesize that chronic and aberrant ATF6 activation promotes non- alcoholic steatohepatitis (NASH)-driven HCC through ER stress, UPR induction, and a metabolic shift to alter cholesterol/bile acid metabolism favoring cancer development and will test the targeted inhibition of ATF6 as a therapeutic strategy for HCC.

PROJECT_TERMS: Acceleration;Acute;Antisense Oligonucleotides;Apoptosis;ATF6 gene;Attenuated;Automobile Driving;bile acid metabolism;Binding;bone;Cancer Etiology;Carcinogens;Cell Death;Cell Line;Cell Nucleus;Cell Survival;Cells;Cessation of life;Cholesterol;cholesterol biosynthesis;Chronic;Citric Acid Cycle;clinically relevant;Collaborations;Computer Analysis;Curiosities;Cytosol;Data;Data Set;Defect;Development;Diet;digital;Down-Regulation;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Etiology;extracellular;Fatty acid glycerol esters;Fatty Liver;feeding;Fructose;Gene Expression Profile;gene product;Genes;Genetic;Genetic Transcription;Golgi Apparatus;Growth;hepatocellular carcinoma cell line;Hepatocyte;High Fat Diet;Human;Human Genome;human tissue;improved;in vivo;Incidence;inhibitor;Injections;insight;Intervention;Link;Lipids;Liver;Liver diseases;liver injury;Malignant Neoplasms;malignant state;Measures;Medical;Metabolic;Metabolic stress;Metabolism;metabolome;metabolomics;migration;misfolded protein;Mitochondria;Modeling;Molecular Chaperones;Monitor;mouse model;Mus;nano-string;neoplastic cell;next generation sequencing;non-alcoholic;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear;Nutrient;Obesity;Obesity Epidemic;Oncogenes;Oncogenic;Oncoproteins;Operative Surgical Procedures;Outcome;patient derived xenograft model;Patients;pharmacologic;Phenotype;Play;pre-clinical;predicting response;Premalignant Cell;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Production;progenitor;prognostic;Proliferating;protein folding;protein misfolding;Proteins;Proteolytic Processing;proteomic signature;proteostasis;Repression;Resected;response;Role;Sampling;Signal Transduction;small molecule;small molecule inhibitor;Solid Neoplasm;Specimen;Steatohepatitis;synergism;Testing;The Cancer Genome Atlas;Therapeutic;Tissue Sample;Tissues;transcription factor;transcription factor CHOP;Transcriptional Activation;transcriptome;transcriptomics;Transducers;Translating;Transplantation;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenic;Viral;Xenograft procedure

PROJECT_TITLE: Project 2: The UPR transducer ATF6 drives HCC in response to metabolic stress


PHR: PROJECT NARRATIVE – PROJECT 3 Overfeeding diet induced NASH has emerged as a major cause of hepatocellular carcinoma. Project 3 focuses on the contribution of two mitochondria proteins, SAB and StARD1, which increase in NASH and further increase in HCC and alter mitochondria function. Project 3 will integrate the metabolic alterations elucidated in Projects 1 and 2 with the role of the mitochondria alterations seen with increased expression of SAB and StARD1 in HCC and will lead to novel therapeutic targets.

PI_NAMEs: KAPLOWITZ, NEIL  (contact)

PROJECT_TERMS: Ablation;acute liver injury;Affect;arm;ATF6 gene;Attenuated;Bile Acid Biosynthesis Pathway;Bile Acids;Cholesterol;cholesterol trafficking;Chronic;CRISPR/Cas technology;Development;Diet;DNA Damage;Docking;effective therapy;endoplasmic reticulum stress;Epidemic;Event;Fatty acid glycerol esters;feeding;Gene Deletion;Generations;Genes;Glycolysis;Grant;hepatocellular carcinoma cell line;Hepatocyte;Homeostasis;Human;hypoxia inducible factor 1;Impairment;Incidence;Inner mitochondrial membrane;knock-down;Lead;lipidome;Lipids;Liver;MAPK8 gene;Mediating;Mediator;Membrane;Membrane Lipids;Metabolic;Metabolic Biotransformation;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel therapeutic intervention;Nude Mice;Obesity;overexpression;Overnutrition;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patients;Phosphatidylserines;Phosphorylation;Primary carcinoma of the liver cells;Proteins;Reactive Oxygen Species;Role;Sampling;senescence;Signal Transduction;spheroids;synergism;Tissues;Transplantation;tumorigenic;Work

PROJECT_TITLE: Project 3: Metabolic stress induces mitochondrial dysfunction through STARD1 and SAB leading to HCC


PHR: NARRATIVE – CORE 1 Fatty liver disease is a frequent precursor to hepatocellular carcinoma. The primary hypothesis of this Program Project Grant is that stress-altered metabolism in the fatty liver leads to further dysfunction in metabolism which contributes to disease progression. The Metabolomics Core will use methods of metabolite quantification and stable-isotope tracing to support Research Projects in an extensive analysis of liver and tumor metabolism.

PI_NAMEs: SCOTT, DAVID ANDERSON (contact)

PROJECT_TERMS: Amino Acids;Animal Model;Area;ATF6 gene;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Bioinformatics;Biological Assay;blood glucose regulation;Cell Line;Cells;Cholesterol;Citric Acid Cycle;Consultations;Data;Data Analyses;Data Set;Deposition;Development;Disease;Disease Progression;endoplasmic reticulum stress;experience;Experimental Designs;experimental study;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;Fatty Liver;fatty liver disease;Functional disorder;Future;Genetic Transcription;Glucose;Glutamine;Glycolysis;Hexosamines;Hexoses;Homeostasis;improved;In Vitro;in vivo;inorganic phosphate;interest;Kinetics;Knowledge;Label;lipid biosynthesis;Lipids;Liver;Liver diseases;Liver Dysfunction;liver metabolism;Mass Fragmentography;Measurement;Measures;member;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolic stress;Metabolism;metabolomics;Methods;Mitochondria;Modeling;nonalcoholic steatohepatitis;nutrition;Pathway interactions;Pentosephosphate Pathway;Plasma;Preparation;Primary carcinoma of the liver cells;Program Research Project Grants;programs;Research;Research Activity;Research Design;Research Project Grants;Research Support;Role;Route;Sampling;Services;Slice;Specimen;stable isotope;Stable Isotope Labeling;Sterols;Stress;Therapeutic Intervention;timeline;Tissue Banks;tissue culture;Tissues;Tracer;tumor;tumor metabolism;Work;Writing

PROJECT_TITLE: Core 1: Metabolomics


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: PROJECT NARRATIVE – CORE 2 Core 2, Bioinformatics / Biostatistics / Genomics Core will provide unified support and consolidation of all the Bioinformatics, Biostatistics, Genomics, Transcriptomics, and Computational Biology relevant to the to the projects. These tools and resources will be made available to the Cancer Research community and will be useful to researchers working in the field and to perform similar analyses in other cancer and conditions.

PI_NAMEs: TAMAYO, PABLO  (contact)

PROJECT_TERMS: anti-cancer research;ATF6 gene;Bioinformatics;Biological Markers;biomarker identification;biomarker validation;Biometry;cancer genomics;Cancer Patient;clinically relevant;Clonal Evolution;cohort;Collection;Communities;comparative;Computational Biology;computational pipelines;Computer Analysis;computerized tools;Computing Methodologies;Data;Data Analyses;data integration;Data Set;Databases;Development;digital;DNA sequencing;driver mutation;dynamical evolution;Gene set enrichment analysis;Genes;genomic data;Genomics;hepatocellular carcinoma cell line;Human;inhibitor;insight;Libraries;Link;Literature;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic;Metabolic stress;Methodology;Methods;Modality;mouse model;Mutation;nano-string;next generation sequencing;nonalcoholic steatohepatitis;novel;Ontology;Organoids;Pathway Analysis;Pathway interactions;Patients;Primary carcinoma of the liver cells;programs;Pythons;Research;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Somatic Mutation;Techniques;Technology;The Cancer Genome Atlas;Tissue Microarray;Tissue-Specific Gene Expression;tool;transcriptome sequencing;transcriptomics


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Microbiome;Orphan Drug;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE We are submitting a renewal for our consortium of Baylor College of Medicine located in Houston and Children’s National Hospital located in Washington DC as a BMT CTN core center. Both centers serve diverse catchment areas that have allowed us to recruit diverse subjects to BMT CTN multicenter studies. We propose a novel and highly feasible protocol to evaluate starch as a microbiome modulating agent that may reduce the risk of graft versus host disease which remains a major transplant complication.

PI_NAMEs: BOLLARD, CATHERINE M.;HESLOP, HELEN E (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute;Adult;Advisory Committees;African American;Allogeneic Bone Marrow Transplantation;Asian;Bacteria;Benign;Biological Response Modifier Therapy;Butyrates;Caring;Catchment Area;Cell Therapy;Child;Childhood;Clinic;Clinical Cancer Center;clinical center;Clinical Research;Clinical Trials;cohort;Collaborations;college;Communication;community engagement;Community Outreach;Complex;Complication;Comprehensive Cancer Center;Disease;District of Columbia;Effector Cell;Enrollment;Ensure;Epithelial Cells;experience;Funding;gastrointestinal;gene therapy;Geographic Locations;geographic population;graft vs host disease;Hematologic Neoplasms;Hematologist;Hematology;Hematopoietic Stem Cell Transplantation;Hereditary Disease;Hispanic;histiocyte;Homologous Transplantation;Hospitals;human subject;Immune;Immune System Diseases;Immunologics;Immunologist;Immunology;Incidence;Intervention;intestinal epithelium;Intestines;Laboratories;Laboratory Research;Leadership;Logistics;Malignant - descriptor;Maps;Medicine;meetings;Metabolic Diseases;microbiome;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;Multicenter Trials;Mus;National Heart, Lung, and Blood Institute;Nature;Non-Malignant;Non-Neoplastic Hematologic and Lymphocytic Disorder;novel;participant enrollment;Patient Recruitments;Patients;Pediatric Hematologist;Performance;Persons;Phase;phase II trial;phase III trial;Physicians;Pilot Projects;Plasma;Population Heterogeneity;post-transplant;Potato;prebiotics;preclinical study;Procedures;Process;Professional Organizations;programs;Protocols documentation;Randomized;recruit;Registries;Regulatory Affairs;Reporting;Reproducibility;Research Personnel;Research Proposals;Research Training;Resistance;Risk Reduction;Science;Scientist;Selection for Treatments;Services;Severities;Severity of illness;Sickle Cell Anemia;Starch;symposium;Testing;Training;translational scientist;Transplant Recipients;Transplantation;tumor;virtual;Work

PROJECT_TITLE: BMT CTN Core: Baylor College of Medicine Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Big data, along with the associated computational and statistical tools, are transforming cancer research and cancer care in almost all aspects. Built on our previous big data training courses for general biomedical researchers and current big data training courses tailored for cancer researchers, this renewal project aims to help cancer researchers develop essential analytical skills to extract knowledge from big data and find better ways to understand, diagnose, and treat cancer. In addition, we will establish a big data community among cancer researchers to foster collaboration and knowledge sharing to advance cancer research endeavors.

PI_NAMEs: ZHANG, MIN  (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acceleration;Administrative Supplement;Advanced Malignant Neoplasm;American Association of Cancer Research;anti-cancer research;Area;Award;Basic Cancer Research;big biomedical data;Big Data;Big Data to Knowledge;Bioinformatics;Biological Assay;Biometry;California;cancer care;Cancer Center;Cause of Death;Cells;Clinical;Clinical Oncology;Clinical Trials;cohort;Collaborations;Colorado;Communication;Communities;community organizations;Competence;Comprehensive Cancer Center;computer science;COVID-19;Data;Data Analyses;Development;Diagnosis;Disease;drug discovery;Early Diagnosis;Education;Educational Curriculum;Educational workshop;effective therapy;empowerment;Ensure;epidemiology study;Event;experience;Family;flexibility;follow-up;Fostering;Funding;Future;Goals;heterogenous data;high throughput technology;Image;Immune;improved;Individual;Informatics;insight;instructor;interest;Intervention;Knowledge;Laboratories;laboratory experiment;large scale data;Learning;learning community;learning materials;lecturer;lectures;Malignant Neoplasms;Mediating;metabolomics;microbiome;multidisciplinary;Nature;new therapeutic target;Paper;Participant;Pathogenesis;patient engagement;Performance;personalized medicine;Persons;Positioning Attribute;pre-clinical;precision oncology;prevent;Process;programs;Publishing;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;response;single molecule;skills;Statistical Methods;success;supercomputer;Surveys;System;Techniques;Time;tool;Training;Training and Education;training data;Training Programs;transcriptomics;United States National Institutes of Health;Universities;University of California Irvine Cancer Center;Update;Visualization;web site

PROJECT_TITLE: Big Data Training for Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: OVERALL – PROJECT NARRATIVE The University of Hawai‘i Cancer Center (UHCC) is dedicated to pioneering cancer research tailored to the distinct ethnic and cultural characteristics of Hawai‘i and the Pacific. Through a blend of innovative research, clinical trials, and robust community outreach and engagement, UHCC prioritizes underserved groups like Native Hawaiians and Pacific Islanders. Supported by many stakeholders, including State and Federal sponsors, our mission is to transform cancer care, emphasizing diversity, equity, and inclusion, ensuring Hawai‘i and the Pacific lead in globally impactful cancer discoveries.

PI_NAMEs: UENO, NAOTO T. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Aging;Analytical Biochemistry;anti-cancer research;Area;Asian Americans;authority;Automobile Driving;base;Basic Cancer Research;Biodiversity;Bioinformatics;Biological;Biometry;Body Composition;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Etiology;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer research center director;Cancer Research Center of Hawaii;cancer risk;cancer therapy;Catchment Area;Characteristics;Clinic;Clinical Investigator;Clinical Research;Clinical Trials;clinically relevant;cohort;Collaborations;collaborative approach;Communities;community engagement;Community Networks;Community Outreach;community setting;Cultural Characteristics;culturally appropriate intervention;Death Rate;Dedications;diversity and equity;Education;Ensure;Environment;equity, diversity, and inclusion;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;Etiology;experience;Extramural Activities;Fostering;Funding;Genetic;Genomics;Geography;Goals;Growth;Guam;Hawaii;health disparity;health equity;health equity promotion;Health Policy;Health Professional;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;inter-institutional;Intervention;Lead;Leadership;Life Style;Location;Malignant Neoplasms;Medical;member;Mission;Monitor;multi-ethnic;National Cancer Institute;Native Hawaiian or Other Pacific Islander;Network-based;next generation;novel;novel strategies;nutrition;Outcome;Pacific Islands;participant enrollment;Patient Care;patient population;Patient Representative;Peer Review;Phase;Policies;Population;Population Heterogeneity;Population Programs;Population Sciences;Positioning Attribute;Prevention;Prevention approach;programs;Provider;Public Health;Public Policy;Publications;Publishing;Race;racial diversity;racial minority;racial population;Recording of previous events;Research;Research Activity;Research Infrastructure;Research Personnel;Research Priority;Research Training;Resource Sharing;Rural;Screening for cancer;Societies;socioeconomics;Students;Therapeutic;Traditional Medicine;Training;Translating;translational cancer research;Translations;Travel;treatment response;underserved area;Underserved Population;Universities;Vision;Vulnerable Populations;Work

PROJECT_TITLE: University of Hawaii Cancer Center CCSG

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MARTIN, CLIFFORD C (contact)

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Automobile Driving;Award;Budgets;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer education;Clinical Trials;Collaborations;Communication;Communication Methods;community engagement;Community Outreach;Data Reporting;Dedications;Development;diversity and equity;diversity and inclusion;Education;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;experience;Extramural Activities;fighting;Fostering;Funding;Grant;Hawaii;Hospitals;Human Resources;human subject;Information Technology;Infrastructure;innovation;Institution;Lead;Leadership;Malignant Neoplasms;meetings;member;Mission;Monitor;National Cancer Institute;operation;Outcome;outreach;Patient Care;Pilot Projects;Play;Policies;Population Sciences;Positioning Attribute;Price;Process;programs;Publications;Quality Control;Research;research facility;Research Infrastructure;Research Support;Research Training;Resource Sharing;Resources;Role;satisfaction;Source;Strategic Planning;Strategic vision;Stream;success;symposium;Training and Education;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: MASKARINEC, GERTRAUD  (contact)

PROJECT_TERMS: anti-cancer research;base;Basic Science;Behavior Therapy;Behavioral Sciences;Bioinformatics;Biometry;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer health disparity;career;career development;Catchment Area;Clinical;Clinical Sciences;Clinical Trials;Collaborations;community engagement;community intervention;Community Outreach;Data;Data Collection;Databases;design;Discipline;Education;education research;Educational Assessment;Educational Curriculum;Educational process of instructing;Educational workshop;Epidemiology;Equity;equity, diversity, and inclusion;ethnic diversity;Ethnic Population;experience;Faculty;faculty mentor;faculty support;Foundations;Funding;Future;Goals;graduate student;Grant;Hawaii;health disparity;Health Professional;high school;High School Student;improved;innovation;Institution;interest;International;Investigational Therapies;Journals;Leadership;Malignant Neoplasms;Measures;Medical;Medical Students;meetings;member;men;Mentors;Mentorship;Minority Groups;mortality;NCI Center for Cancer Research;next generation;novel;nutrition;Outcome;Participant;peer support;Population Sciences;Postdoctoral Fellow;Process;Program Appropriateness;Program Development;programs;Publications;racial population;Research;Research Personnel;Research Training;Resource Sharing;Scientist;Services;skills;success;Surveys;symposium;Training;Training Activity;Training and Education;Training Programs;Training Support;Translational Research;Travel;undergraduate student;Underrepresented Minority;Universities;Vision;Woman

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PALAFOX, NEAL A. (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affinity;Ally;anti-cancer research;Basic Science;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;Cancer Patient;cancer research center director;cancer risk;Cancer Survivor;career;Career Mobility;Catchment Area;Characteristics;Clinical Research;Clinical Trials;Collaborations;college;Communities;community advisory board;community college;community engagement;community organizations;Community Outreach;Creativeness;Cultural Backgrounds;cultural equity;Development;disparity reduction;Diverse Workforce;Education;Educational Status;Educational workshop;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Faculty;Family;Filipino;Financial Support;First Generation College Students;Fostering;Foundations;Gender;Gender Identity;Geography;Goals;graduate student;Grant;Guam;Hawaii;Healthcare;high school;high school program;Human Resources;Infrastructure;innovation;Institution;interest;Leadership;Manuscripts;Mediation;member;Mentors;Mission;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Occupations;operation;Organizational Policy;organizational structure;Outcome;outreach;Pacific Islands;Patient Care;Personal Satisfaction;Pilot Projects;Policies;Population;Population Heterogeneity;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Prevention;Productivity;programs;Published Comment;Race;recruit;Recruitment Activity;Religion;Reporting;Research;research faculty;Research Infrastructure;Research Personnel;Research Support;Research Training;Resource Sharing;Resources;Role;Rural;Sex Orientation;skills;Socioeconomic Status;socioeconomics;Strategic Planning;Students;Training;Underrepresented Populations;Universities;university student;Woman;Work;Writing

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: CHEN, XIN  (contact)

PROJECT_TERMS: Address;Analytical Biochemistry;Animals;anti-cancer research;Anti-tumor Natural Products;Antibodies;Area;Basic Science;Biochemical;Bioinformatics;Biological Markers;biomarker development;biomarker driven;biomarker validation;Biomedical Research;Biometry;Breast;Cancer Biology;cancer biomarkers;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer prevention;cancer therapy;cancer type;Catchment Area;Chemicals;Chemistry;Clinic;Clinical;clinical application;clinical diagnostics;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;Collaborations;college;Communities;Community Clinical Oncology Program;Conduct Clinical Trials;Core Facility;demographics;Development;Diagnosis;Diagnostic;Direct Costs;drug discovery;Drug resistance;drug sensitivity;Early Diagnosis;Engineering;Environmental Exposure;ethnic diversity;Ethnic Population;experience;Fostering;Funding;Genes;Genetic;Genomics;Geographic Locations;Geography;Goals;Growth;Hawaii;Hawaiian;health disparity;Image;Immunologics;Immunotherapy;improved;Incidence;innovation;insight;inter-institutional;Intervention;Invaded;Island;Kinesiology;Knowledge;Lead;Liver;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;member;Mesothelioma;Microscopy;Modality;Molecular;Molecular Profiling;mortality;multi-ethnic;multidisciplinary;Native Hawaiian or Other Pacific Islander;Natural Products;Neoplasm Metastasis;new therapeutic target;novel;novel anticancer drug;novel therapeutics;Outcome;Pacific Islands;Pathology;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pharmacy facility;Phase;Population;Population Sciences;Positioning Attribute;pre-clinical;Preventive;Process;Prognosis;prognostic;prognostication;programs;Publications;Research;Research Activity;Research Personnel;Resource Sharing;response;Screening for cancer;Services;Skin;small molecule;Strategic Planning;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;therapy development;tool;Translating;translational applications;translational cancer research;translational clinical trial;translational potential;Translational Research;Treatment outcome;tumor initiation;Tumor Markers;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Biology Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Electronic Nicotine Delivery Systems;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Microbiome;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: PARK, SUNGSHIM LANI (contact)

PROJECT_TERMS: abdominal fat;Address;Adolescent;Advanced Malignant Neoplasm;aging biomarker;American;anti-cancer research;Area;Asian Americans;Attention;Attenuated;Behavior;Behavior Therapy;Behavioral;Behavioral Research;biobehavior;Biological;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Breast Cancer Risk Factor;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer education;cancer epidemiology;Cancer Etiology;cancer health disparity;Cancer health equity;cancer prevention;Cancer Prevention Intervention;cancer risk;cancer survival;Cancer Survivor;carcinogenesis;care delivery;Caring;Catchment Area;Characteristics;Classification;climate change;Clinical Psychology;Collaborations;Communities;culturally appropriate intervention;Cyanotoxin;Data;Data Science;Development;Diet;Direct Costs;Disparity;disparity reduction;DNA Methylation;Doctor of Philosophy;Electronic cigarette;electronic cigarette use;Environmental Exposure;Environmental Risk Factor;epidemiology study;epigenetic marker;epigenomics;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Faculty;Fatty acid glycerol esters;Genetic;Geographic Locations;Goals;gut microbiome;Hawaii;Health behavior;high risk population;imaging modality;improved;Indigenous;Infectious Agent;informatics tool;innovation;Institution;inter-institutional;Intervention;intervention effect;Intra-abdominal;Knowledge;Life Style;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;member;Metabolic;Metabolism;methylation biomarker;microbiome research;Mission;multidimensional data;National Cancer Institute;Native Hawaiian or Other Pacific Islander;Nicotine;Nicotine Dependence;Not Hispanic or Latino;novel;novel marker;nutrition;Nuts;Obesity;Obesity associated cancer;obesity risk;Outcome;Pacific Islands;Patients;Pattern;Physical activity;Population;Population Heterogeneity;Population Research;Population Sciences;Positioning Attribute;prevent;Prevention program;Prevention strategy;programs;Psychosocial Assessment and Care;Publishing;Quality of life;Race;racial difference;racial population;radiomics;Research;Research Personnel;Resource Sharing;Risk;Risk Behaviors;Risk Factors;Role;Schools;screening;Screening for cancer;Smoking;social;social determinants;Social Psychology;sociocultural determinant;statistics;Strategic Planning;Structural Racism;Subgroup;substance use;Survivors;synergism;Testing;Tobacco;Tobacco smoking behavior;Tobacco use;Translating;Translational Research;treatment response;United States National Institutes of Health;Universities;uptake;Visceral;Visceral fat;Vulnerable Populations;Work

PROJECT_TITLE: Population Sciences in the Pacific Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LE MARCHAND, LOIC  (contact)

PROJECT_TERMS: Address;Affect;American Samoa;Awareness;Basic Science;Behavioral;Biological;Breast;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;cancer prevention;Cancer Prevention Trial;cancer risk;Caring;Catchment Area;Characteristics;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community advisory board;Community Clinical Oncology Program;community engagement;Community Health Education;Community Outreach;community partners;Country;Cultural Diversity;culturally appropriate intervention;Death Rate;demographics;Development;Diet;Disparity;Economic Development;economic disparity;Education;Educational Activities;Enrollment;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Event;Evidence based intervention;experience;Federated States of Micronesia;Fostering;Free Association;Future;Geography;Goals;Guam;Guidelines;Hawaii;Hawaiian;Health behavior;Health education;Health Status;Human Resources;improved;Incidence;Indigenous;Infrastructure;innovation;Intervention Trial;Island;Knowledge;Lead;Leadership;Liver;Lung;lung cancer screening;Malignant Neoplasms;Marshall Islands;member;Minority Participation;Mission;Monitor;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Northern Mariana Islands;Oncology;Outcome;outreach;Pacific Islands;Palau;Patient Care;Persons;Policies;Population;Population Research;Population Sciences;Prevention;programs;Public Health;Public Policy;Race;racial diversity;racial minority;racial population;Recommendation;Research;Risk Factors;screening guidelines;social;success;Time;Translational Research;underserved minority;Underserved Population;United States;Universities

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Area;Basic Science;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Catchment Area;Clinical;clinical application;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Development;Diagnosis;drug development;Education;effectiveness evaluation;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Hawaii;health disparity;improved;innovation;Investigation;investigator-initiated trial;Investments;Leadership;Malignant Neoplasms;member;Mission;multi-ethnic;NCI-Designated Cancer Center;next generation;novel;Operations Research;Organoids;Pacific Islands;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peer Review;Peer Review Grants;Persons;Pilot Projects;Population;Population Heterogeneity;pre-clinical;Prevention;Process;programs;Publications;recruit;Research;Research Activity;Research Personnel;research vision;Resource Sharing;Scientist;Services;Strategic Planning;Time;Training and Education;Translating;translational physician;Translational Research;translational scientist;United States;Universities;Vision;Wages;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Developmental Funds


PI_NAMEs: WILKENS, LYNNE R (contact)

PROJECT_TERMS: Address;Analytical Biochemistry;anti-cancer research;Behavioral;Bioinformatics;Biological;Biometry;Body Composition;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Etiology;Catchment Area;Characteristics;Collaborations;community engagement;Community Outreach;cost;data acquisition;Data Analyses;Disparity;Education;Education and Outreach;Equipment;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Faculty;Feedback;Genomics;Geography;Goals;Hawaii;Incidence;Institution;Instruction;instrumentation;investigator training;Laboratories;Malignant Neoplasms;meetings;member;Mission;mortality;nutrition;operation;Patient Care;Play;Population Sciences;Positioning Attribute;programs;Research;Research Design;Research Personnel;Research Support;Research Technics;Research Training;Resource Sharing;Resources;Role;Running;satisfaction;Science;Services;social;Strategic Planning;Students;Surveys;Technology;tool;Training;Universities;Update

PROJECT_TITLE: Shared Resources Management


PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;anti-cancer research;Area;Asian population;Burn injury;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer research center director;Cancer Research Center of Hawaii;Catchment Area;Characteristics;Charge;Chinese;Clinical;Clinical Research;Clinical Trials;Collaborations;collaborative approach;Communication;Communities;community engagement;community organizations;Community Outreach;Consensus;Decision Making;Dedications;design;Education;Effectiveness;Elements;Ensure;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Faculty;Filipino;Fostering;Funding;Future;Goals;Grant;Hawaii;improved;Individual;Infrastructure;insight;Institution;Japanese;Koreans;Laboratories;Leadership;Malignant Neoplasms;medical schools;meetings;member;Mind;Mission;Monitor;Outcome;Outcomes Research;Patient Care;Patients;Physician Executives;Population;Population Heterogeneity;Population Sciences;Positioning Attribute;Prevention;Principal Investigator;Process;programs;Published Comment;Recommendation;recruit;Reporting;Research;Research Personnel;Research Training;Resource Allocation;Resource Sharing;response;Role;Scientific Advances and Accomplishments;Strategic Planning;Structure;success;Translational Research;Universities;Update;Vision;Woman

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: CHO, JONATHAN KARL (contact)

PROJECT_TERMS: 20 year old;Address;Adverse effects;Age;age group;age related;base;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;Cancer Patient;Catchment Area;Child;Clinic;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;clinical training;clinical translation;clinical trial recruitment;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Communities;community engagement;COVID-19 pandemic;Data;data integrity;data management;data quality;Death Rate;Dedications;demographics;Development;Disease;disparity elimination;Doctor of Philosophy;early phase clinical trial;Education;Enrollment;Ensure;Ethics;ethnic diversity;Exclusion;experience;Filipino;Goals;Hawaii;Hospitals;Human Subject Research;Individual;Industry;Information Technology;Infrastructure;innovation;Intervention;Intervention Trial;investigator-initiated trial;Leadership;life span;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Minority;Minority Enrollment;Minority Groups;Monitor;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Oncology;operation;outreach;pandemic disruption;Participant;participant enrollment;participant safety;Patient advocacy;patient engagement;Patient Monitoring;Patient Participation;Patient risk;patient safety;Patients;Peer Review;Physician Executives;Play;Population;Prevention;programs;Protocol Compliance;Protocols documentation;Provider;quality assurance;Regulatory Affairs;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Role;Rural Community;Safety;Science;screening;Site;success;support network;System;Therapeutic Intervention;Therapeutic Trials;timeline;Training;Training Activity;Training and Education;Trust;underserved community;Universities;welfare;Woman;working group

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: BERENBERG, JEFFREY LEE (contact)

PROJECT_TERMS: Achievement;anti-cancer research;Area;authority;Breast;cancer care;Cancer Center;Cancer Center Support Grant;cancer research center director;care delivery;Catchment Area;Chest;Clinical;Clinical Research;Clinical Research Associate;Clinical Research Protocols;Clinical Trials;Communication;Community Networks;design;Discipline;Disease;Doctor of Philosophy;Electronic Mail;Electronics;empowerment;Ensure;Evaluation;Funding;gastrointestinal;Genitourinary system;Goals;Guidelines;Gynecologic Oncology;Hawaii;Health system;Hematologic Neoplasms;Hospitals;Industrialization;Industry;Infrastructure;Institutional Review Boards;investigator-initiated trial;Logistics;Malignant Neoplasms;Melanoma;member;Mission;Monitor;Neurologic Oncology;Notification;Oncologist;Oncology;operation;Outcome;patient population;Pediatric Oncology;Peer Review;Population;prevent;Probability;Process;Protocols documentation;Provider;Recommendation;Reporting;Research;Research Personnel;Research Support;Resources;Review Committee;Role;Sarcoma;Scientific Evaluation;Site;software systems;sound;Strategic Planning;symptom management;System;timeline;Training;Universities;working group

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Alzheimer’s disease (AD) is a disease of the brain that has frustrated patients, clinicians, and caregivers alike, given the lack of effective treatments and a poor understanding of the complex reasons that cause the variety of syndromic manifestations of the disease. This 3D Aging & Alzheimer Brain Program is a collaborative effort to generate state-of-the-art information at the microscopic level to capture the complexity of the human brain and transform our perspective of the significant variation in the severity of cognitive dysfunction and presentation of AD across individuals. The resources we generate with this Program will help to determine the combinations of genes, cell types, pathologies, and molecular signals in the context of the three-dimensional environment that are most relevant for AD, greatly accelerating the development of new therapeutic targets.

PI_NAMEs: DE JAGER, PHILIP L (contact);MENON, VILAS ;PHATNANI, HEMALI

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;age effect;Aging;aging brain;aging related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Antibodies;Architecture;Atlases;Autopsy;Blood Vessels;Brain;Brain Diseases;Brain imaging;BRAIN initiative;Brain region;brain tissue;Caregivers;Cell Aging;cell community;cell type;Cells;Central Nervous System Diseases;Cerebral Amyloid Angiopathy;Clinical;Cognitive;Cognitive aging;cohort;Communities;Complement;Complex;Data;Data Set;Development;Disease;effective therapy;Elderly;Environment;Foundations;Frustration;Funding;Gene Combinations;Generations;Genes;Growth;Human;Image;Impaired cognition;Indirect Immunofluorescence;Individual;insight;Knowledge;Knowledge Portal;life span;Location;Magnetic Resonance Imaging;Medicine;Methodology;Microscopic;Molecular;Multiomic Data;Neocortex;Neurobiology;neuropathology;neurovascular unit;new therapeutic target;Outcome;Output;Participant;Pathologic;Pathology;Patients;Positioning Attribute;programs;promote resilience;protein TDP-43;Proteomics;Protocols documentation;Research;Research Personnel;Resources;Rest;Risk Factors;RNA;Sampling;Scientist;Senile Plaques;Senior Scientist;Severities;Signal Transduction;single nucleus RNA-sequencing;Surface;Susceptibility Gene;Talents;tau Proteins;Techniques;therapeutic development;Thinness;Tissues;transcriptomics;two-dimensional;United States National Institutes of Health;Variant

PROJECT_TITLE: Defining the effect of Alzheimer pathologies on the aged brain in 3 dimensions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DE JAGER, PHILIP L (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Achievement;Address;age effect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid;Atlases;Autopsy;Awareness;Brain;brain tissue;Cells;Cerebral Amyloid Angiopathy;Charge;Collaborations;Committee Members;Communication;Communities;Complement;Computer Analysis;cost;Data;data hub;data integration;data quality;data resource;design;Documentation;Education;Ensure;Environment;Event;experience;Financial Activity;Freezing;Generations;Goals;Immunohistochemistry;Impaired cognition;improved;Individual;insight;interest;Knowledge;Knowledge Portal;Laboratories;Leadership;Lewy Bodies;Management Information Systems;Measurement;meetings;Methodology;Methods;Molecular;molecular modeling;molecular phenotype;multidimensional data;multimodal data;multiple omics;National Institute on Aging;Neocortex;neuropathology;operation;Participant;Pathology;Process;Production;program dissemination;Program Evaluation;programs;protein TDP-43;Proteomics;Protocols documentation;repository;Research;research data dissemination;Research Project Grants;Resolution;Resource Sharing;Resources;Specimen;Structure;symposium;synergism;System;tau Proteins;Techniques;Time;Tissues;transcriptomics;United States National Institutes of Health;Visualization;web site;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KAPASI, ALIFIYA  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;age effect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Area;Atlases;Atrophic;Attention;Autopsy;biobank;Brain;Brain region;brain tissue;Cells;Cerebral Amyloid Angiopathy;Characteristics;Clinical;clinical phenotype;cohort;Collaborations;Collection;Communities;Computer Analysis;Consent;Data;data sharing;Databases;Development;Diagnosis;Elderly;Ensure;Evaluation;experimental study;Generations;Genetic;Goals;Human;Image;Impaired cognition;improved;Indirect Immunofluorescence;innovation;interest;International;Laboratories;life span;Link;Management Information Systems;Measurement;Measures;method development;Methodology;Minority;Molecular;Monitor;multidimensional data;multiple omics;Neocortex;neocortical;Neurodegenerative Disorders;New York;Office of Administrative Management;Outcome Measure;Participant;Pathologic;pathological aging;Pathology;Phenotype;phenotypic data;Positioning Attribute;Prefrontal Cortex;Preparation;Process;Production;programs;prospective;Proteomics;Protocols documentation;research study;Resources;sample collection;Sampling;Services;Shipping;Site;Source;Specimen;Standardization;Structure;Superior temporal gyrus;Techniques;Testing;therapeutic development;Tissue Banks;tissue processing;Tissues;Training Programs;trait;transcriptomics;Universities

PROJECT_TITLE: Core B: Biospecimen Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: PHATNANI, HEMALI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Age;age related;age related changes;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Antibodies;Autopsy;Blood Vessels;Brain;Brain Mapping;Brain region;brain tissue;cell assembly;cell type;Cerebral Amyloid Angiopathy;Clinical;Computer Analysis;Data;data acquisition;data integration;data quality;Data Set;Development;Disease;Ensure;Etiology;experimental study;Freezing;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Goals;Health;Human;Human Resources;Image;Indirect Immunofluorescence;Individual;information processing;innovation;Laboratories;large scale data;Lead;Link;Management Information Systems;Maps;Methods;Molecular;multimodal data;multiple omics;Neocortex;neocortical;new technology;novel;Participant;Pathologic;Pathology;Pattern;Physiology;Play;Population;Prefrontal Cortex;Process;programs;protein aggregation;protein biomarkers;protein expression;Proteomics;Protocols documentation;Publishing;Reproducibility;Research;Resolution;Risk Factors;Role;Sampling;secondary analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;Source;Standardization;Structure;Superior temporal gyrus;tau Proteins;Techniques;Technology;Testing;tissue preparation;Tissue Sample;Tissues;transcriptomics;Validation;validation studies;Work

PROJECT_TITLE: Core C: Spatial Multiomics Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Though fewer than 20% of older adults perform the recommended amount of resistance training, systematic reviews show that it has a strong effect on improving strength and physical function. While briefer resistance training sessions, which older adults prefer, have been proven to increase strength, no Phase 2 efficacy studies have been conducted to understand their impact on improving physical function, including mobility. If this trial shows that a brief, daily resistance training program improves lower extremity performance and mobility, this study may alter guidelines for resistance training and, by making programs shorter, potentially improve their uptake by older adults and, in doing so, improve the public’s health.

PI_NAMEs: SCIAMANNA, CHRISTOPHER N. (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Activities of Daily Living;Adherence;Affect;Anxiety;behavior change;Cessation of life;Clinical;Control Groups;Data;design;disability;effective therapy;efficacy study;efficacy trial;Electronic Mail;Enrollment;evidence based guidelines;Exercise;Exertion;falls;Feedback;Financial Hardship;Functional impairment;functional improvement;Future;Goals;Guidelines;Health;Health Care Costs;Heterogeneity;Home;Hour;improved;improved mobility;improved outcome;Intervention;Laws;Lead;Leg;Life;Lower Extremity;Measures;meetings;men;Mental Depression;Minority;Mobility disability;Monitor;Multicenter Studies;novel;novel strategies;older adult;Pain;Participant;Patients;Performance;Persons;Phase;Physical Function;Physical Performance;prevent;programs;Public Health;Quality of life;Randomized;Recommendation;Reporting;resistance exercise;Risk;satisfaction;Services;Silver;strength training;Subgroup;Supervision;Surveys;systematic review;Techniques;Testing;Time;Training Programs;treatment effect;Uninsured Medical Expense;Upper Extremity;uptake;Visit;Walking;Woman;Work

PROJECT_TITLE: Impact of brief daily functional resistance training on lower extremity physical performance

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: MENON, VILAS  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Age;age related changes;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Anus;Atlases;Blood Vessels;Brain;Brain Mapping;Brain Pathology;brain tissue;cell type;Cells;Communities;Computer Analysis;Data;Data Analyses;data modalities;Derivation procedure;Dimensions;Disease;Education;Feedback;Gene Expression;Gene Expression Profile;Generations;genome-wide;genomic data;Goals;Human;Image;image registration;Individual;large scale data;Link;Maps;Measurable;Modeling;multiple omics;Pathologic;Pathology;Process;protein aggregation;protein expression;Reproducibility;Research Personnel;Resolution;Risk Factors;RNA;Sampling;scale up;secondary analysis;Spatial Distribution;stem;Tissues;transcriptomics;usability;Work

PROJECT_TITLE: Core D: Integrated Computational Analysis Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: 3-Dimensional;Age;age effect;age related;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Amyotrophic Lateral Sclerosis;Antibodies;Atlases;Autopsy;Behavioral;Blood Vessels;Brain region;brain tissue;cell injury;cell type;cerebrovascular;Cerebrovascular Disorders;Chromosome Mapping;Clinical;Cognitive;cohort;computer framework;Computer Models;Data;data integration;Data Set;Defect;Development;Disease;Dissociation;Environment;Frontotemporal Dementia;Gene Expression;Gene Expression Profile;Generations;Genes;genome-wide;Genomics;Global Change;Goals;Human;human tissue;Image;image registration;imaging Segmentation;Immunohistochemistry;In Situ Hybridization;Indirect Immunofluorescence;Individual;Investigation;late life;Lewy Body Dementia;limbic-predominant age-related TDP-43 encephalopathy;Maps;Measurement;Measures;Messenger RNA;Methods;Modeling;Molecular;Molecular Profiling;Motor;multimodality;Neocortex;Neurodegenerative Disorders;normal aging;novel;Parkinson Disease;Pathology;Pathway interactions;Patients;Predisposition;Prefrontal Cortex;Progressive Supranuclear Palsy;protein expression;Proteins;Proteome;Resolution;scale up;secondary analysis;single nucleus RNA-sequencing;Spatial Distribution;Standardization;Superior temporal gyrus;Techniques;Thick;Time;Tissue Sample;Tissues;transcriptome;transcriptomics;Vascular Diseases;Work

PROJECT_TITLE: Project 1: 3-D Molecular atlas of the aging brain


PROJECT_TERMS: 3-Dimensional;abeta accumulation;aged;aging brain;aging related disease;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyotrophic Lateral Sclerosis;Antibodies;Appearance;Astrocytes;Atlases;Autopsy;Brain region;brain tissue;brain volume;Cell Nucleus;cell type;Cellular Structures;computer framework;Data;density;Development;Diffuse;Disease;Environment;Female;Frontotemporal Dementia;Gene Expression;Gene Expression Profile;Generations;Genes;genome-wide;Goals;Heterogeneity;Human;human tissue;Image;Impaired cognition;In Situ Hybridization;Individual;Lewy Bodies;male;Maps;Measurement;Measures;Messenger RNA;Methods;Molecular;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;novel;Parkinson Disease;Pathologic;Pathology;Prefrontal Cortex;protein aggregation;protein expression;protein TDP-43;Reproducibility;Research;Resolution;scale up;Senile Plaques;single nucleus RNA-sequencing;Spatial Distribution;Stains;Superior temporal gyrus;Symptoms;tau Proteins;Thick;Tissue Sample;Tissues;transcriptome;transcriptomics

PROJECT_TITLE: Project 2: 3-D Molecular atlas of AD proteinopathy


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative We propose to use ultrasound to activate genes and epigenetics in live cells. We will engineer molecular sensors into T cells along with genetic transducing modules, and use ultrasound to induce CAR expression for therapeutic actions against solid tumors. We will also develop technology and protocols for ultrasound controllable genetic and epigenetic regulations in treating diseases.

PI_NAMEs: WANG, YINGXIAO  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Biological Process;Biology;Biosensor;cancer therapy;Cell Physiology;Cell Reprogramming;Cells;cellular engineering;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;clinical application;Disease;Engineering;Epigenetic Process;epigenetic regulation;Event;Fluorescence Resonance Energy Transfer;Genes;Genetic;Genetic Transduction;Immunotherapy;in vivo;Medicine;Methods;Molecular;molecular dynamics;novel strategies;optogenetics;Organism;Pathologic Processes;Production;Proteins;Protocols documentation;receptor expression;Resolution;sensor;Signal Transduction;Site;Solid Neoplasm;spatiotemporal;System;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transducers;Ultrasonic Transducer;ultrasound;Visualization

PROJECT_TITLE: Acoustothermogenetics for Cell Engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: SCHNEIDER, JULIE A. (contact)

PROJECT_TERMS: 3-Dimensional;abeta deposition;Affect;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Antibodies;Atlases;Autopsy;Blood Vessels;Brain region;brain tissue;cell type;Cerebral Amyloid Angiopathy;Chromosome Mapping;comorbidity;computer framework;Data;Dementia;Development;Dissociation;Elderly;Elements;Environment;Gene Expression;Gene Expression Profile;Generations;Genes;genome-wide;Goals;Human;human tissue;Image;Immunohistochemistry;Impaired cognition;In Situ Hybridization;Indirect Immunofluorescence;Individual;Leptomeninges;Lewy Bodies;Maps;Measurement;Measures;Methods;misfolded protein;Modeling;Molecular;Molecular Profiling;Nerve Degeneration;neuropathology;neurovascular unit;non-demented;novel;Occipital lobe;Older Population;Pathogenesis;Pathology;Phase;Predisposition;Prefrontal Cortex;protein expression;protein TDP-43;Proteins;Research;Research Project Grants;Resolution;Sampling;scale up;Severities;single nucleus RNA-sequencing;Spatial Distribution;Standardization;Superior temporal gyrus;tau Proteins;Temporal Lobe;Thick;Time;Tissue Sample;Tissues;transcriptome;transcriptomics;transmission process;Vascular Diseases;Work

PROJECT_TITLE: Project 3: 3-D Molecular Atlas of cerebral amyloid angiopathy in the aging brain with and without co-pathology


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LOWELL

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: This project will build capacity for participatory science among the Maine tribes in order to facilitate a balance between food and water sovereignty and environmental contamination. The incorporation of traditional ecological Knowledge (TEK) into exposure and risk assessment models will allow community members to make more realistic and informed evaluation of risks that allow a balance between traditional lifestyles and contaminant exposures. The ultimate goal is to provide the foundations for a larger program that will serve the environmental health needs of Maine’s Tribal communities while respecting their sovereignty over traditional foods and waterways.

PI_NAMEs: FORD, TIMOTHY EDGCUMBE (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Affect;Agriculture;Archives;climate change;climate impact;Collaborations;Communication;Communities;community based participatory research;community engagement;Consumption;contaminated water;Data;design;Ecosystem;Environment;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Environmental Pollution;Equilibrium;Evaluation;experience;exposure pathway;exposure route;Face;Fishes;Food;food consumption;Food Contamination;food resource;Foundations;Goals;Health;Human;Indigenous;Knowledge;Laboratories;Life Style;Maine;member;Methods;Modeling;Monitor;Natural Resources;novel;Pattern;Persons;Play;Pollution;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Predisposition;Process;programs;Public Health;public health research;Publishing;repository;Research Institute;Research Personnel;resilience;Resources;Risk;Risk Assessment;Risk Management;risk mitigation;Role;sample collection;Sampling;Schools;Science;sound;System;Techniques;Testing;Time;tool;Toxic effect;Training;trend;tribal community;Tribal Elders;Tribes;Universities;Water;Youth

PROJECT_TITLE: "ahbahjipdooneh woolibahmowsoowahkn": reclaiming indigenous health through water and food sovereignty

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: 3-Dimensional;Affect;African American;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;American;Amyloid;Brain;brain tissue;Categories;Cell Nucleus;Cells;Cerebral Amyloid Angiopathy;Characteristics;Clinical;Cognitive;cognitive performance;cohort;Complement;Data;Data Analyses;data framework;Data Set;Dedications;demented;design;Dimensions;distributed data;drug development;Elderly;Ensure;epigenomics;Evaluation;Genes;Genetic Variation;Goals;Heterogeneity;Impaired cognition;Impairment;Individual;insight;Investigation;Knowledge Portal;Lewy Bodies;Link;Microglia;Molecular;multiple omics;Neocortex;neocortical;Neurodegenerative Disorders;neuropathology;Neuropsychology;next generation;Not Hispanic or Latino;novel;Older Population;Outcome;Participant;Pathologic;Pathology;Planet Mars;Population;Prefrontal Cortex;programs;protein TDP-43;Proteins;Proteomics;Research Personnel;Resources;Risk Factors;Role;Sample Size;Sampling;Sister;Source;spatial integration;Stains;Superior temporal gyrus;tau Proteins;Testing;Tissue Sample;Tissues;trait;transcriptome sequencing;transcriptomics;Variant;whole genome

PROJECT_TITLE: Project 4: Integrative analysis of spatial molecular features and clinico-pathological characteristics


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Neglect dyslexia, a reading impairment associated with post-stroke spatial neglect, presents a major barrier to regaining functional independence in activities of daily living, work, and leisure participation. The goal of the proposed research is to characterize the mediative role that gaze may have in neglect dyslexic errors. Biometric, behavioral, and neuroimaging data collected will inform basic cognitive neuroscience research on the neural networks that support spatial cognition, and applied neurorehabilitation research aimed at improving the detection and classification of visuospatial deficits such as neglect dyslexia.

PI_NAMEs: RICH, TIMOTHY JOHN (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Activities of Daily Living;Affect;American;Applied Research;Area;Arousal;Attention;Basic Science;Behavior;behavior test;Behavioral;Bilateral;Biometry;Brain;Brain Mapping;Brain scan;Classification;Clinical assessments;Cognition;cognitive neuroscience;Data;Detection;Diagnosis;Dorsal;Dyslexia;Etiology;experience;experimental study;Eye;Eye Movements;Face;Functional disorder;functional gain;functional independence;Funding;gaze;Goals;Head;Impairment;improved;Individual;innovation;interest;Intervention;Left;Leisures;Lesion;Letters;Literature;Location;Maps;Measures;Mentored Research Scientist Development Award;Modeling;National Institute of Child Health and Human Development;neglect;nerve injury;neural network;Neuroanatomy;neuroimaging;Neurologic;neurological rehabilitation;Neuropsychology;Neurosciences Research;novel;Outcome;Participant;Patients;Pattern;Play;Population;Positioning Attribute;post stroke;Predictive Value;Reader;Reading;Reading Disorder;rehabilitation science;Rehabilitation therapy;Research;Role;Rotation;Side;spatial neglect;Stimulus;Stroke;stroke survivor;support network;Symptoms;Technology;Training;treatment response;United States National Institutes of Health;vigilance;virtual reality environment;visual stimulus;visual tracking;Visuospatial;wearable device;Work

PROJECT_TITLE: Gaze, Head Rotation, and Neuroanatomic Correlates of Reading Errors in Neglect Dyslexia

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The purpose of our proposed study is to elucidate how mutations in the heat shock protein DNAJC7 cause ALS/FTD, an untreatable and devastating neurodegenerative disease. We will use induced pluripotent stem cell- derived neurons in combination with quantitative mass spectrometry-based proteomics to elucidate the role of DNAJC7 in human neurons and determine how its dysfunction leads to their dysfunction.

PI_NAMEs: FLEMING, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;aged;ALS patients;Amyotrophic Lateral Sclerosis;Appearance;Binding;Biochemical;biological adaptation to stress;Biological Process;Case Study;Cell model;Cell Physiology;cell type;Cells;Cellular Stress;Central Nervous System;Client;Clinical;Complex;Coupled;CRISPR/Cas technology;Critical Pathways;Data;Disease;Dissociation;DNA Sequence Alteration;Exhibits;exome sequencing;experimental study;Fractionation;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;functional loss;Genes;Genetic;Genetic Transcription;genetic variant;Heat shock proteins;heat-shock proteins 40;Heat-Shock Proteins 70;Heat-Shock Response;Heterozygote;HSF1;Human;Induced pluripotent stem cell derived neurons;Lead;Light;loss of function;loss of function mutation;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;misfolded protein;Molecular Chaperones;Molecular Weight;motor control;Motor Neurons;mRNA Stability;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;novel;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Play;polypeptide;Predisposition;Process;protein metabolism;Protein Truncation;Proteins;Proteome;Proteomics;proteostasis;Rare Diseases;Regulation;response;RNA;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Solubility;Spinal;sporadic amyotrophic lateral sclerosis;Stress;Testing;trafficking;Transcript;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: Defining the mechanisms by which mutations in DNAJC7 increase susceptibility to ALS/FTD


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: At least one in three Veterans has high levels of triglycerides that raises their risk of heart disease. A high fat meal raises triglyceride levels with the greatest rise about four hours after the meal. During this peak time, the risk of inflammation and hardening of the arteries also increases. Although fats are created differently, we don’t understand how each of these fats behave after a high fat meal. This study will examine these fats separately by having Veterans with high triglycerides drink a “milkshake” containing purified coconut oil, salmon oil, or sunflower oil to better understand how these fats are processed; and whether one may be preferred due to a lower rise in triglycerides, inflammation, and other markers of heart disease.

PI_NAMEs: MILLER, MICHAEL  (contact)

PROJECT_TERMS: Acceleration;Adhesions;Advocate;Age;American Heart Association;Arteries;aryldialkylphosphatase;Atherosclerosis;Biological Markers;Biological Process;Blood Pressure;Blood Vessels;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;Cell Adhesion Molecules;CETP gene;Cholesterol;Chronic;Clinical;Coconut Oil;Collaborations;Confusion;cytokine;Data;Diet;dietary;Dietary Fats;Disease;Endothelial Cells;endothelial stem cell;Endothelium;experience;Exposure to;Fasting;Fatty acid glycerol esters;Gender;gut microbiome;heart disease risk;Heart Diseases;High Density Lipoproteins;Hour;Hypertriglyceridemia;Impairment;improved;In Vitro;indexing;Inflammation;Inflammation Mediators;Inflammatory;insight;Lipids;Lipoproteins;Macrophage;Mediating;Mediator;Metabolic;Metabolic syndrome;Metabolism;MicroRNAs;Molecular;monocyte;monolayer;monounsaturated fat;Nutritional Biochemistry;Oils;oxidation;Pathway interactions;Phase;Physiological;polyunsaturated fat;Process;Production;Proteins;Randomized;Research;Research Personnel;response;Risk;Role;Salmon;saturated fat;Serum;Signal Pathway;Sunflower Oil;systemic inflammatory response;Testing;Thrombosis;Time;Triglycerides;trimethyloxamine;Up-Regulation;uptake;vascular inflammation;Vasodilation;Veterans

PROJECT_TITLE: Effect of Differential Fat Loads on CVD Biomarkers in Veterans with HTG


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PHR: NARRATIVE. Hispanics/Latinos show higher prevalence and incidence of AD compared to non-Hispanic Whites but their representation in genetic studies remains insufficient to provide statistical significance, especially for rare variant discovery. In this study we will generate whole genome sequencing data (WGS) on N=2,000 newly-recruited Peruvian and Bolivian individuals (with extensive clinical, cognitive assessment and AD-biomarkers panel) and N=4,000 HL from US (part of our recently funded study “Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP” U19AG074865). These new cohorts will increase representation of HL in AD genetic studies, particularly for samples with substantial Native American ancestry that are currently underrepresented compared to other admixed samples with predominant African ancestry (e.g., African Americans, Caribbean Hispanics).

PI_NAMEs: MARTIN, EDEN R.;PERICAK-VANCE, MARGARET A.;TOSTO, GIUSEPPE  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: adjudication;Admixture;admixture mapping;African;African American;African American population;African ancestry;Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Americas;Amyloid beta-42;Behavior;Biological Markers;biomarker panel;Blood;Blood specimen;Bolivia;Bolivian;Caribbean Hispanic;cell repository;Clinical;Clinical Data;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Collection;Complex;Data;Data Collection;data sharing;data storage site;Deposition;Disease;DNA;Ensure;Environmental Risk Factor;European;follow-up;Follow-Up Studies;Foundations;Frequencies;Funding;Funding Opportunities;Future;Genetic;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;Genotype;Glass;Guidelines;Health;Heterogeneity;High Prevalence;Hispanic;Hispanic Populations;human genomics;Immigrant;Incidence;Indigenous;Individual;innovation;Latino Population;Maps;Methods;Mexican;mild cognitive impairment;multi-ethnic;Native American Ancestry;Native Americans;non-genetic;Not Hispanic or Latino;Peru;Peruvian;Phenotype;Plasma;polygenic risk score;Population;Population Heterogeneity;Preparation;Quechua;rare variant;recruit;Research;Risk;Risk Factors;sample collection;Sample Size;Sampling;Services;Site;sociodemographics;South American;study population;tau Proteins;Testing;Time;Universities;Visit;whole genome

PROJECT_TITLE: GLASS-AD: Global Latinos Sequencing Study for Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Significant technical heterogeneity and batch effects are commonly observed across multiple batches of data. We will develop algorithms and software to address specific gaps facing researchers combining data from genomic or epigenomic experiments. We will develop algorithms and software for integrating data from single cell, microbiome, and spatial/imaging data, and benchmarking batch effect methods and their performance.

PI_NAMEs: JOHNSON, WILLIAM EVAN (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Algorithms;Benchmarking;Biological;Biological Assay;biomarker development;cell type;Cells;Cluster Analysis;combat;Computer software;Data;Data Adjustments;Data Correlations;data integration;data resource;Data Set;design;Detection;differential expression;Dimensions;epigenomics;Evaluation;Excision;experimental study;Generations;genomic data;Heterogeneity;heterogenous data;Image;imaging platform;improved;Lead;Methods;microbiome;Modeling;mRNA sequencing;multiple data sources;multiple datasets;Nature;novel;Outcome;outcome prediction;Pathway Analysis;Performance;Protocols documentation;Reagent;Research;Research Personnel;Sample Size;single-cell RNA sequencing;software development;Software Tools;Source;Standardization;Structure;Taxonomy;tool;transcriptomics;Variant;Work

PROJECT_TITLE: Removing batch effects in high-throughput biomedical studies

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Pediatric

ORG_NAME: HOOLA MUSIC AND CULTURAL ARTS

PHR: SCI-ENCE Project Narrative The SCI-ENCE Program will increase interest in science and STEAM careers by creating and implementing an elementary and middle/intermediate school science curriculum based on storyboards, or illustrated descriptions of the science pathways that local individuals have taken to pursue science careers. These storyboard pathways are scattered with age-appropriate and NGSS aligned games, activities and experiments for students to do during each year of school from grades 2 to 8. Science fascination, career interest, confidence, engagement and literacy will be increased, as will teacher confidence in teaching science as a result of this program.

PI_NAMEs: MEAD, KAUIONALANI  (contact);WITHY, KELLEY MARIE

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: after-school program;Age;age group;career;career awareness;Career Choice;Communities;Complex;disadvantaged student;Educational Curriculum;Educational Materials;Educational process of instructing;elementary school;experience;experimental study;Federated States of Micronesia;field trip;Goals;Grant;Habitats;Hand functions;Hawaii;Hawaiian;Immersion;Individual;innovation;Instruction;interest;Language;Learning;literacy;meetings;Mentors;Methodology;Middle School Student;Participant;Pathway interactions;Privatization;Process;programs;Recommendation;Research;Research Activity;Resources;Schools;Science;Scientist;Services;skills;Students;teacher;Teacher Professional Development;Training;Visit;web site;Youth

PROJECT_TITLE: Science Career Inquiry - Exploring Native Cultural Experiences (SCI-ENCE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PARIS

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: OSIVAX SAS

PHR: NARRATIVE Seasonal influenza is estimated to result in 9-45 million cases of illness, 140,000-810,000 hospitalizations and 12,000-61,000 deaths in the US annually, especially in people at high risk; a pandemic influenza outbreak could account for >30 million deaths worldwide within the first 6 months and cost $600B. As current influenza vaccines target elements on the surface of the virus that are highly prone to mutations, they require annual updates, their effectiveness may be as low as 10-20% when circulating viruses do not match the vaccine viruses and are expected to provide very limited protection against emerging pandemic strains. Osivax has developed a vaccine that recognizes an internal influenza target, which is highly conserved across all influenza strains. In this grant we propose to test how broadly effective this vaccine can be in a monkey model that best mimics the human condition.

PI_NAMEs: LE GRAND, ROGER ;NICOLAS, FLORENCE  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Adjuvant;age group;Animals;Antibodies;Antibody Response;Antigen Targeting;Antigens;arm;Avian Influenza;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cessation of life;Clinical;Conduct Clinical Trials;cost;cost estimate;cross reactivity;current pandemic;Dose;Effectiveness;Elements;Exposure to;Future;global health;Glycoproteins;Grant;high risk;Hospitalization;Human;Immune response;Immunity;Immunization;immunogenic;immunogenicity;improved;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;influenza outbreak;influenza virus strain;influenza virus vaccine;Length;Membrane Proteins;Modeling;Monkeys;Mus;Mutation;National Institute of Allergy and Infectious Disease;new pandemic;nonhuman primate;novel;novel strategies;Nucleoproteins;pandemic disease;pandemic influenza;pandemic potential;Pathogenicity;Patients;Persons;Phase;Populations at Risk;prevent;protective efficacy;Recombinant Proteins;research and development;Research Design;Respiratory Disease;seasonal influenza;Seasons;Structure;Surface;Surface Antigens;T cell response;T-Lymphocyte;Technology;technology platform;Testing;universal influenza vaccine;Update;Vaccination;vaccine development;Vaccines;Virus

PROJECT_TITLE: Broad spectrum protection and immune responses induced by an NP-based universal influenza vaccine in heterologous NHP challenge model

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE A major goal in biomedicine is to modulate a protease solely on its disease-related substrates. To achieve this rare level of selectivity, this proposal aims to combine a novel high-throughput selection platform with machine learning tools to accelerate the discovery of substrate-selective protease modulators and decipher their binding mechanisms. Given that proteases and other post-translational modification enzymes are implicated in a vast number of diseases, including cancer, neurodegeneration, infectious and autoimmune diseases, substrate- selective modulators could have a profound impact on how we target and study enzymes with multiple substrates.

PI_NAMEs: DENARD, CARL  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Autoimmune Diseases;beta secretase;Binding;Biochemistry;Communicable Diseases;Communication;Data;design;Disease;Distal;drug discovery;Engineering;Enzymes;Epitopes;experience;Functional disorder;Goals;Guidelines;high throughput screening;HIV Protease;human disease;Insulinase;Investigation;Libraries;Ligands;Machine Learning;machine learning algorithm;Malignant Neoplasms;Maps;Molecular;Molecular Conformation;multidisciplinary;mutation screening;nanobodies;Nerve Degeneration;Neurosciences;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Peptide Hydrolases;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Physiological;Post-Translational Protein Processing;preference;Process;programs;Property;Proteins;Protocols documentation;Regulation;remediation;Research;Site;Structure;success;therapeutic target;tool;Training;Work

PROJECT_TITLE: Reprogramming proteases: tackling human diseases with next-generation modulators


PHR: Project Narrative This project will develop a new spatial proteomics technology for high-plex, 3D spatial mapping of protein markers and single cells in large tissues using highly parallel fluorescence spectrum and lifetime imaging. This tool will broadly enable us to study how the spatiotemporal regulation of protein expression, cell function and their cooperation mediates organ development, tissue homeostasis, and disease formation and to develop personalized diagnostics and treatments.

PI_NAMEs: GRATTON, ENRICO ;KESSENBROCK, KAI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Alzheimer's Disease;antibody conjugate;Architecture;Base Sequence;Basic Science;Benchmarking;Biological;Biological Assay;Biological Process;Biology;Biopsy;brain tissue;Cell Physiology;Cells;Clinical;clinical application;clinically relevant;Color;Communities;Complementary DNA;Complex;computerized data processing;Consumption;cost;cost effective;Cytometry;Data;data visualization;Detection;Development;Dimensions;Disease;DNA Microarray Chip;DNA Probes;Equipment;Exhibits;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;fluorophore;Homeostasis;Image;Immunofluorescence Immunologic;Immunohistochemistry;Immunooncology;In Situ;indexing;instrument;Label;Lasers;Maps;Mass Spectrum Analysis;Measurement;Mediating;Methods;Modality;Nature;neuroinflammation;new technology;novel;Oligonucleotides;optical spectra;organ growth;Pathologic;Patient Care;patient stratification;Patients;Performance;personalized diagnostics;personalized medicine;Phenotype;Physiologic pulse;Positioning Attribute;Process;Protein Analysis;protein biomarkers;protein expression;protein profiling;Proteins;Proteome;Proteomics;prototype;Publishing;Regulation;Reproducibility;Research;Resolution;Sampling;scale up;Shapes;single cell sequencing;spatiotemporal;Specific qualifier value;Specificity;Stains;System;technological innovation;Technology;Thick;Thinness;Time;Tissue Model;tissue processing;Tissues;tool;tumor;Tumor Tissue;two-photon;Validation;Visualization;Visualization software;Work

PROJECT_TITLE: Spatial proteomics using highly parallel fluorescence hyperspectral and lifetime imaging

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]