NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Protein kinases orchestrate a wide range of cellular processes and play integral roles in cardiac development, function, and disease, making them attractive therapeutic targets. A member of the Protein Kinase Novel (PKN) family, PKN2, is dysregulated in numerous human cardiac conditions and is essential for cardiac development. Proposed studies will help us to understand the biological function of PKN2 in cardiomyocytes at molecular, cellular, and physiological levels, and identify critical PKN2 substrates as well as determine a safe therapeutic window for the potential application of PKN2 inhibitors in heart failure.

PI_NAMEs: CHEN, JU  (contact)

PROJECT_TERMS: Acute;Address;Adult;Age Months;analog;Angiotensin II;Atrial Fibrillation;Biological Process;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Physiology;Cells;chemical genetics;Chronic;Coronary Arteriosclerosis;Defect;Development;Dilated Cardiomyopathy;Disease;Echocardiography;Embryo;Family;genetic approach;genome wide association study;Heart;Heart Abnormalities;heart defect;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Immune;inhibitor;Knock-out;Knockout Mice;Left;Lymphoid;member;Molecular;Morphology;mouse model;Mus;mutant;Myelogenous;Myocardial Infarction;Neonatal;novel;Patients;Phenotype;phosphoproteomics;Phosphotransferases;Physiological;Play;postnatal;postnatal development;pressure;protective effect;Protein Kinase;Protein Kinase C;Proteins;Publishing;Quantitative Trait Loci;Reporting;Risk;Role;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Skeletal Muscle;small molecule inhibitor;Smooth Muscle;Structure;Tamoxifen;Therapeutic;therapeutic target;vector;Ventricular;Weaning

PROJECT_TITLE: Protein Kinase Novel 2 (PKN2) in heart

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Emergency Care;Health Services;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DRINKSAVVY, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cerebrospinal fluid (CSF) leaks occur when the protective fluid surrounding the brain and spine escapes through tears caused during traumatic brain injuries, spinal surgeries and otolaryngological surgeries and, if left undiagnosed, increase a patient’s risk for infections, meningitis, stroke and death. Chemeleon, Inc. is developing an easy-to-use colorimetric biosensor that rapidly changes color in minutes in the presence of CSF, a significant advancement from current detection technologies which require sending samples to external labs for results in 4-7 days. Chemeleon’s CSF biosensor will be operated by physicians and EMTs at the point-of-care, providing near-instantaneous results to help prevent future complications and improve patient outcomes.

PI_NAMEs: HU, MIN  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Accident and Emergency department;Ambulances;aptamer;Bacterial Infections;Binding;Biological;Biological Assay;Biological Markers;Biosensor;Blood;Blood specimen;Body Fluids;Brain;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cerebrospinal Fluid Rhinorrhea;Cessation of life;Chemistry;Clinical;Color;commercial prototype;Craniocerebral Trauma;Decision Making;design;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;digital media;Distress;Ear;Emergency medical service;Emergency Medical Technicians;emergency settings;Ensure;Equipment;Evaluation;experimental study;Extravasation;Eye;Frequencies;Future;Health Care Costs;Healthcare;Hospitalization;Human Resources;improved;In Transferrin;In Vitro;in-vitro diagnostics;Infection;infection risk;Instruction;Laboratories;large scale production;Left;Life;Liquid substance;manufacturing process;manufacturing scale-up;Medical;Membrane;Meningitis;Methods;Modification;Morbidity - disease rate;nanophotonic;Nanostructures;Nose;novel;Operative Surgical Procedures;Optical reporter;Optics;Otorhinolaryngologic Surgical Procedures;Otorrhea;Pathology;Patient risk;Patient-Focused Outcomes;Patients;Performance;Phase;phase 2 study;Physicians;point of care;point-of-care diagnostics;Postoperative Care;prevent;Process;Property;protein biomarkers;Proteins;prototype;Quality Control;rapid diagnosis;receptor;Reporter;Reproducibility;Research;Risk;Rupture;Sampling;scale up;Sensitivity and Specificity;sensor;skull base;Specificity;Specimen;Spinal Puncture;Spine surgery;standard of care;Stroke;success;Surface;Surgeon;Surgical complication;TBI Patients;Technology;technology platform;Testing;Time;Training;Transferrin;trauma surgery;Traumatic Brain Injury;usability;Validation;Vendor;Vertebral column;Work

PROJECT_TITLE: Development of a Colorimetric Sensor for Detection of Cerebrospinal Fluid Leaks


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This project will examine how gentrification affects mobility patterns at the neighborhood levels and changes exposure to contextual determinants of health that have been shown to contribute to social and race/ethnic inequalities in health. The project builds on efforts to use longitudinal data based on traces directly produced by consumer activity with broad population coverage and high level of spatial and temporal specificity. This approach addresses the shortcomings of traditional demographic data sources, such as surveys, to establish the impact of gentrification on mobility and contextual determinants of health.

PI_NAMEs: ACOLIN, ARTHUR  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Affect;Air Pollution;Area;Asthma;Buffers;built environment;Censuses;Characteristics;Chronic;Communities;Data;Data Set;Data Sources;Databases;Demography;deprivation;design;Destinations;Diabetes Mellitus;Disadvantaged;Disparity;Economics;Environment;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Event;experience;Exposure to;Gender;Geography;Green space;Health;health determinants;health disparity;health equity;health inequalities;Health Promotion;Household;Housing;Income;Individual;Infrastructure;innovation;Investigation;Investments;Length;Life Expectancy;Literature;Location;longitudinal dataset;Low income;Malignant Neoplasms;Marketing;Measures;Medically Underserved Area;Methods;metropolitan;Migrant;migration;multidisciplinary;Neighborhoods;novel;Obesity;open source;Outcome;Pathway interactions;Pattern;Policies;Population;population health;Process;Public Health;Race;racial disparity;racial health disparity;racial minority;Research;residence;Residential Mobility;segregation;social;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;Sociology;Source;Specificity;Surveys;Testing;theories;Work

PROJECT_TITLE: Gentrification, Mobility, and Exposure to Contextual Determinants of Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE: As treatments for rare genetic conditions become more broadly available, the need to identify at-risk individuals as early as possible has become increasingly important. This proposal presents a five-year research career development plan that will allow me to develop a unique set of interdisciplinary skills, thereby enabling my transition to independence as a physician-scientist focused on the implementation of preventive genomic medicine. The proposed research will demonstrate proof-of-concept for genome-first approaches and result in new estimates of prevalence and penetrance of risk variants associated with treatable genetic conditions in unselected populations.

PI_NAMEs: GOLD, NINA BETH (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Acceleration;adjudication;Adult;Affect;Area;Award;behavioral outcome;biobank;Biochemical Pathway;cancer predisposition;career;career development;Caring;Clinical;Code;Data;design;Development;Development Plans;Diagnosis;Diagnostic;Diet;Disease;economic outcome;Electronic Health Record;exome sequencing;experience;Face;follow-up;Foundations;Frequencies;Future;gene therapy;Genes;Genetic Diseases;Genetic Risk;genetic variant;Genome;genome sequencing;genomic data;Genomic medicine;Genomics;Genotype;Guidelines;Health;Heart Diseases;Hematopoietic Stem Cell Transplantation;Hospitals;immunodeficiency;improved;Individual;Infant;Inherited;International;Laboratory Study;Life Style;Marfan Syndrome;Medical;Medical History;Medicine;Mendelian disorder;Mentors;Metabolic;Metabolic Diseases;Neonatal Screening;Noonan Syndrome;Outcome;outcome prediction;Participant;Pathogenicity;Penetrance;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;population based;Prevalence;Preventive;Preventive screening;Program Development;programs;Public Health;rare genetic disorder;Recommendation;Recontacts;Research;Risk;risk stratification;risk variant;Scientist;screening;screening panel;Severity of illness;skills;Surveys;Symptoms;Syndrome;System;Testing;Time;Training;Variant;Visit;Work

PROJECT_TITLE: Genome-first approach to treatable genetic conditions in adults

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Transforming Growth Factor (TGF)-Beta superfamily members play a critical role in repair, remodeling and fibrosis of the infarcted heart, signaling through intracellular effectors, the Smads and through non-Smad pathways. The current proposal will investigate cell- specific actions of Smad1 cascades in the infarcted heart. In vivo experiments using cell- specific knockout mice, in vitro loss- and gain-of-function studies and single cell RNAseq experiments will be performed to study Smad1-mediated actions on fibroblasts, macrophages, cardiomyocytes and pericytes, to dissect the molecular mechanisms responsible for Smad1 effects, and to explore the role of TGF-Beta signaling responses in mediating subset-specific functions of immune and reparative cells.

PI_NAMEs: FRANGOGIANNIS, NIKOLAOS G (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Activins;Acute;Affect;angiogenesis;Anti-Inflammatory Agents;Attenuated;Binding;Biological Assay;Blood Vessels;Bone Morphogenetic Proteins;Cardiac;Cardiac Myocytes;cardiac repair;Cells;Characteristics;chemokine;Cicatrix;Complex;Cytokine Activation;Data;Development;Differentiation and Growth;Down-Regulation;Endothelial Cells;Event;experimental study;Family;Fibroblasts;Fibrosis;Flow Cytometry;Follistatin;Functional disorder;gain of function;Geometry;Growth Factor;healing;Heart failure;Heterogeneity;Hypertrophy;Immune;immune function;In Vitro;in vitro Assay;in vivo;Infarction;Inflammation;Inflammatory Response;insight;Integrins;interstitial;Ischemia;Knockout Mice;Ligand Binding;loss of function;Macrophage;Mediating;member;Molecular;morphogens;mortality;Myeloid Cells;Myocardial;Myocardial Infarction;Myocardium;Myofibroblast;Pathway interactions;Patients;Pericytes;Phagocytes;pharmacologic;Phenotype;Play;Property;Protein Isoforms;Proteomics;Reactive Oxygen Species;receptor;recruit;Regulation;repair function;repaired;Reperfusion Therapy;Resolution;response;restraint;Role;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;STAT6 gene;Stromal Cell-Derived Factor 1;Testing;TGF-beta type I receptor;TGFB1 gene;TGFBR2 gene;Time;TP53 gene;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;transforming growth factor beta3

PROJECT_TITLE: Resolution of inflammation in healing myocardial infarcts

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Infectious Diseases;Lung;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Sepsis

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Patients with severe bleeding (hemorrhagic shock) due to trauma and other causes, who often also have infection and sepsis, can develop a deadly complication called acute lung injury. In this project, we will establish how the new inflammatory mediator eCIRP gets released after injury and activates the intracellular sensor STING to cause acute lung injury and death, and evaluate the benefit of a new eCIRP inhibitor, A12, on acute lung injury and survival after hemorrhagic shock complicated by sepsis. This project will establish the importance of these new mechanisms for the development of acute lung injury after hemorrhage and sepsis, and explore a new way to treat patients with these conditions.

PI_NAMEs: WANG, PING  (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Affinity;Age Years;American;Animals;antagonist;Attenuated;Binding;Blood;Cause of Death;Cells;Cessation of life;Circulation;Complication;cytokine;Cytoplasm;Data;Deoxyribonucleases;Development;Dimerization;Discipline of obstetrics;Disease;Disulfiram;DNA;DNA Fragmentation;Dose;drug candidate;Endotoxins;Exposure to;extracellular;gastrointestinal;Gene Activation;Golgi Apparatus;Half-Life;Hemorrhage;Hemorrhagic Shock;Hospital Mortality;Human;Hypovolemia;Hypovolemics;Hypoxia;improved;in silico;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;inhibitor;Injury;insight;Interferon Type I;Interleukin-1 beta;Knockout Mice;Life;Lipopolysaccharides;Lung;Macrophage;Military Personnel;Mitochondrial DNA;Modeling;Molecular;Monoclonal Antibodies;mortality;Mus;novel;Operative Surgical Procedures;Organ;organ injury;palmitoylation;Pathogenesis;Pathway interactions;Patients;Pattern;Phosphorylation;Play;Population;Protein Inhibition;public health relevance;Resuscitation;RNA;RNA-Binding Proteins;Role;sensor;Sepsis;septic patients;Serum;Severities;Severity of illness;Stimulator of Interferon Genes;systemic inflammatory response;Therapeutic;Time;tissue injury;TLR4 gene;TNF gene;Trauma;Traumatic injury;type I interferon receptor;Up-Regulation

PROJECT_TITLE: Improvement of Organ Function after Severe Hypovolemia


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The overall goal of the United States-Mali Research Ethics Training Program (US-Mali RETP) is to strengthen research ethics education and research in Mali through an innovative model of sustainable capacity development to prepare the next generation of ethics researchers. Our approach will be based on close collaboration between George Washington University (GWU) Milken Institute School of Public Health (GWSPH), USA - and University of Science, Techniques & Technologies of Bamako (USTTB), Mali and is aimed at supporting USTTB’s vision of becoming a regional focus for research ethics in French Speaking west Africa. These institutions have a great commitment to understanding the ethical issues around health research, experience and expertise in research and a history of collaborative work and build on their twenty years of experience developing ethics training in Africa and the research environment built at USTTB plus over 25 years of collaboration between USTTB and NIH.

PI_NAMEs: DOUMBIA, SEYDOU ;HYDER, ADNAN A (contact);NDEBELE, PAUL

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: academic program;Address;Africa;Area;base;Bioethics;built environment;burden of illness;Clinical Research;Clinical Trials;Collaborations;Communication;Country;Dedications;design;Development;Disease;Distance Learning;Ebola;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Environment;Epidemic;Ethical Issues;Ethics;expectation;experience;Faculty;Funding;Future;Generations;Genetic;genetic approach;Genomics;Goals;Grant;Health;health care delivery;Health Services;Home;Human;improved;innovation;Institution;Institutional Review Boards;Instruction;International;Knowledge;Lead;Leadership;Learning;life span;low income country;Mali;Master of Science;member;Mentors;model development;Modeling;next generation;online course;Policies;Program Development;programs;Public Health;Public Health Schools;Recording of previous events;Research;research and development;Research Ethics;Research Ethics Committees;Research Personnel;Research Priority;Research Support;Research Training;Risk Factors;Science;Teacher Professional Development;technology/technique;Testing;Training;Training Programs;Trust;United States;United States National Institutes of Health;Universities;Vision;Visit;Washington;webinar;Work


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: We have identified genetic variants in inbred strains of mice which profoundly impact the initiation of cardiomyocyte cell cycle activity following myocardial injury. The experiments proposed in this application will identify the gene (or genes) responsible for this cell cycle activity and determine if they have a beneficial impact on the heart following injury. Ultimately, the identification and validation of genes underlying intrinsic differences in cardiomyocyte cell cycle rates could suggest potential therapeutic targets with which to enhance regenerative growth in injured hearts.

PI_NAMEs: FIELD, LOREN J (contact)

PROJECT_TERMS: Abbreviations;Adult;Alleles;Anatomy;Animals;Apoptosis;autosome;Backcrossings;Bromodeoxyuridine;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cell Cycle;Cell Cycle Progression;chromosomal location;Chromosome 3;Congenic Mice;coronary fibrosis;Distal;Echocardiography;Exhibits;exome sequencing;experimental study;Genes;Genetic;genetic testing;genetic variant;Genetically Modified Animals;genome editing;Heart;heart function;Heart Injuries;hemodynamics;Heterozygote;Hypertrophy;Image Analysis;improved;Inbred DBA Mice;Inbred Mouse;Inbred Strains Mice;Infarction;Infusion procedures;Injury;insight;interest;Location;Measurement;Molecular Analysis;Monitor;Mouse Strains;Mus;Myocardial;Myocardial Infarction;myocardial injury;Natural regeneration;Nucleotides;offspring;Pattern;Phenotype;protein structure;regenerative growth;Reporter;S phase;Structure;System;Systems Analysis;Testing;therapeutic development;therapeutic target;Time;trait;transcriptome sequencing;Transgenes;Transgenic Organisms;Validation;Variant;Ventricular Remodeling

PROJECT_TITLE: Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: 8. Project narrative  Despite being a cause of tremendous morbidity to the aging population, treatment of stroke is presently poor in part because of limited understanding of the events set in motion by ischemia that culminate in loss of function and nerve cell death. In this study, we use in vitro and in vivo paradigms to follow up on compelling leads from ourselves and a large number of others investigators over the past two decades highlighting Zn2+ accumulation in neurons as a critical but inadequately understood early event in brain ischemia that plays an integral role in the initiation of downstream injury cascades. We hope that the studies will ultimately lead to improved understanding of mechanisms triggering delayed injury after ischemia and suggest potential new approaches for targeting them.

PI_NAMEs: WEISS, JOHN H (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;aging population;antagonist;Area;Binding;Brain;Brain Ischemia;brain tissue;Cell Death;Cerebrum;Chelating Agents;chelation;Cytoplasm;deprivation;Development;disability;Disease;Divalent Cations;Drug usage;Event;excitotoxicity;follow-up;Glucose;Glutamates;Goals;Heart Arrest;Hilar;hippocampal pyramidal neuron;Hippocampus;Homeostasis;Hour;Imaging Techniques;improved;improved outcome;In Vitro;in vivo;in vivo Model;Injury;insight;Intervention;Ions;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Neuronal Injury;Link;loss of function;Measurement;Membrane;Mitochondria;mitochondrial dysfunction;Modeling;Morbidity - disease rate;mortality;Motion;N-Methylaspartate;Nerve Degeneration;neuron loss;Neuronal Injury;Neurons;neuroprotection;novel strategies;Oxygen;Pathogenicity;Pathologic;Pharmacotherapy;Play;Population;postsynaptic;Preparation;preservation;Process;protective efficacy;Rattus;Recurrence;Reperfusion Therapy;Research Personnel;restoration;Role;Seizures;Severities;Site;Slice;Source;stroke model;stroke therapy;Synapses;synaptic function;Testing;Therapeutic Intervention;therapeutically effective;Time;uptake

PROJECT_TITLE: Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Rett syndrome (RTT) is a neurodevelopmental disorder with a high mortality rate caused in part by respiratory dysfunction. RTT is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2); however, it is not known how disruption of MeCP2 disrupts breathing. This project seeks to establish novel roles MeCP2 and Kir4.1/5.1 channels in astrocytes as the cellular and molecular basis of sleep-wake state dependent respiratory problems in a mouse model of RTT.

PI_NAMEs: MULKEY, DANIEL K (contact);OLSEN, MICHELLE L

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: adenovirus mediated delivery;Affect;Animal Model;Animals;Astrocytes;autistic behaviour;Behavior;Brain;Brain region;Brain Stem;Breathing;Carbon Dioxide;Cell Nucleus;Cessation of life;Communication;comorbidity;Data;Death Rate;Electrophysiology (science);Elements;extracellular;Extracellular Space;Failure;Genes;Goals;Grant;Homeostasis;human model;improved;In Vitro;in vivo;insight;Ions;Knockout Mice;Link;loss of function mutation;Measurement;Mediating;Membrane Potentials;Methyl-CpG-Binding Protein 2;Molecular;Morphology;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neurons;novel;Online Mendelian Inheritance In Man;patient population;Patients;Phenotype;Plethysmography;premature;Process;Quality of life;Reflex action;Regulation;Respiration Disorders;respiratory;response;Rett Syndrome;Role;Seizures;Site;Sleep;Slice;Symptoms;targeted treatment;Testing;therapeutic target;Tissues;Viral;Wakefulness;Work

PROJECT_TITLE: Glial chemosensitivity and control of breathing in Rett syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: LOWELL

ORG_NAME: DYNOCARDIA, INC.

PHR: Project Narrative The hypertensive diseases of pregnancy are a significant cause of morbidity and mortality. ViTrack™ is a cuffless, wrist-wearable device that uses a fundamentally new method to accurately and non-invasively measure blood pressure. This study will validate ViTrack as the first standalone wearable device for accurate and continuous blood pressure monitoring during pregnancy.

PI_NAMEs: THANIKACHALAM, MOHAN  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: accurate diagnosis;Address;Ambulatory Blood Pressure Monitoring;antenatal;arm;Arteries;Black Populations;black women;Blood Pressure;blood pressure control;Blood Pressure Monitors;Blood Vessels;circadian;Clinic;Clinical;Continuity of Patient Care;Contralateral;Data;Devices;Diagnosis;Early Diagnosis;European;follow-up;Grant;Health;Heart;Heart Rate;hemodynamics;high risk;Home;Hospitals;Hour;Hypertension;Hypertensive Episode;Hypotensives;improved outcome;Individual;Inpatients;International;Lead;masked hypertension;Measurement;Measures;meetings;Methods;Monitor;Morbidity - disease rate;mortality;Movement;Not Hispanic or Latino;Office Visits;Operating Rooms;Outcome;Outpatients;patient tolerability;Patients;Patients' Rooms;Pattern;Periodicals;Phase;phase 2 study;Posture;pre-clinical;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Pregnancy Outcome;Pregnant Women;pressure;prevent;Prevention;Proteinuria;Protocols documentation;Randomized, Controlled Trials;Reporting;respiratory;risk prediction;Skin;Sleep disturbances;Small Business Innovation Research Grant;Societies;spatiotemporal;standard measure;standard of care;Technology;Underserved Population;usability;Validation;Visit;wearable device;Woman;Wrist

PROJECT_TITLE: ViTrack: Wearable, accurate, continuous blood pressure monitor to improve outcomes in hypertensive diseases of pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-V(11)B]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Chronic Pain;Hematology;Microbiome;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative: Pain is the most common complication for patients with sickle cell disease. Very little is known about how sickle cell disease pain is processed in the brain, and as a result, few non-opioid based therapies are used to treat this symptom. In this proposal, we will manipulate gut bacteria in sickle cell disease mice then measure pain-related brain activity and behaviors to identify new targets for sickle cell disease pain treatments.

PI_NAMEs: SADLER, KATELYN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Pain;Adult;Advisory Committees;Affect;Affective;affective disturbance;afferent nerve;Agonist;Amygdaloid structure;Anatomy;Antibiotics;Anxiety;Automobile Driving;Award;Behavior;Behavioral;Brain;Brain imaging;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;central pain;central sensitization;Chemicals;Childhood;chronic pain;chronic painful condition;comorbidity;Complication;Data;depressive symptoms;Disease;disease model;dysbiosis;Exhibits;experimental study;Fiber;Foundations;Frequencies;Fright;G-Protein-Coupled Receptors;Gene Expression Profile;Germ-Free;Goals;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;HTR2A gene;Hypoxia;Individual;Inflammatory;Injections;Injury;Intestines;job market;Laboratory Research;Learning;Measures;Mediating;medical schools;Mental Depression;Mentors;microbial;microbiome;microbiome research;Modeling;mouse model;Mus;Nerve;Neurobiology;neuronal circuitry;Neurons;Neuropathy;neurotransmission;Neurotransmitters;Nociception;non-opioid analgesic;novel;Nucleus solitarius;Operative Surgical Procedures;Opioid;optogenetics;Output;Pain;Pain intensity;Pain management;Pain Measurement;pain processing;parabrachial nucleus;Pathology;Patients;Penicillins;Peripheral Nervous System;personalized therapeutic;Phase;Photometry;Population;pre-clinical;Probiotics;Process;prophylactic;Proxy;Publishing;receptor;Reporting;Research;Research Personnel;Role;Sensory;Serotonin;Serotonin Production;Serotonin Receptor 5-HT2A;Sickle Cell Anemia;side effect;Signal Pathway;Signal Transduction;Site;Social Interaction;Source;Spinal;Structure;symptom treatment;tenure track;Testing;Time;Training;Transgenic Organisms;Vagotomy;Variant;Veno-Occlusive Disease;Visceral;Wild Type Mouse;Wisconsin;Work

PROJECT_TITLE: Sickle cell disease gut dysbiosis effects on CNS pain processing

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Adjuvants are used to promote immune responses and formulate efficacious vaccines. Here we evaluate adjuvant combinations with mast cell agonists, evaluate it as a vaccine against an animal model of smallpox and evaluate its mechanism of action.

PI_NAMEs: AINSLIE, KRISTY M (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acids;adaptive immune response;Adjuvant;aging population;Agonist;aluminum sulfate;Anaphylaxis;Animal Model;antigen test;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Area;Attenuated;Autoimmunity;Autopsy;Binding;Biocompatible Materials;Blood Chemical Analysis;Categories;CD8-Positive T-Lymphocytes;Cell Degranulation;Cells;Cold Chains;Contracts;controlled release;cytokine;cytotoxicity;Data;Delayed Hypersensitivity;Dextrans;Dose;draining lymph node;Elderly;Emulsions;Encapsulated;Ensure;Environment;Evaluation;Formulation;Genes;Genetic;Genetic Variation;Goals;Histamine;Histology;Human;human model;Hydrophobicity;IgE;Immune;Immune response;Immune system;Immunity;Immunization;Immunohistochemistry;Immunologic Stimulation;In Vitro;in vivo;Inbred Strains Mice;Infection;insight;Knockout Mice;Langerhans cell;Leukocytes;Leukotrienes;Lipid A;Liposomes;Lymphocyte;Maps;mast cell;Measures;Memory;Memory B-Lymphocyte;Methods;Modeling;monocyte;mouse model;Mouse Strains;Mus;Nucleotides;old mice;Ovalbumin;particle;pathogen;Pathology;Pattern recognition receptor;Peptides;Population;Population Heterogeneity;Predisposition;Production;Prostaglandins;protective effect;Proteins;Receptor Cell;Recombinants;recruit;Reporting;Resources;response;Safety;Schedule;Serum;Severity of illness;Site;small molecule;Smallpox;Stimulator of Interferon Genes;Subunit Vaccines;synergism;T cell response;TLR2 gene;Toll-like receptors;tool;Toxic effect;Tryptase;United States National Institutes of Health;Vaccination;vaccine efficacy;vaccine evaluation;vaccine formulation;Vaccine Research;Vaccines;Vaccinia;Vaccinia Vaccine;Viral;Work

PROJECT_TITLE: Mechanistic evaluation of mast cell agonists combined with TLR, NOD and STING agonists.

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Clinical Research;Estrogen;HIV/AIDS;Infectious Diseases;Microbiome;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Statement Women living with HIV may have a unique inflammatory response to HIV infection, partially attributable to sex- specific factors (such as the sex hormone estrogen) and sexual behavior-specific factors (such as participation in receptive anal intercourse). In this study, we will focus on defining these patterns of systemic and gut inflammation in treated HIV infection, and elucidating the microbial and molecular mechanisms driving these inflammatory signatures. This information could be critical for the development of sex-appropriate interventions for mitigating chronic inflammation in persons living with HIV.

PI_NAMEs: KELLEY, COLLEEN F;SMITH, STACEY ABIGAIL (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Age;Anal Sex;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;Bacteroides;Basic Science;Biopsy;Blood;Body mass index;Cause of Death;CCL2 gene;CD4 Positive T Lymphocytes;CD80 gene;Cells;chemokine;Chronic;cohort;comorbidity;cytokine;design;Development;dimensional analysis;Dose;dysbiosis;Educational workshop;End stage renal failure;Enterobacteriaceae;Environment;Estradiol;Estrogen Receptors;Estrogens;experience;Future;Gender;General Population;Genes;Genetic Transcription;Gonadal Steroid Hormones;gut inflammation;gut microbiome;gut microbiota;Gut Mucosa;HIV;HIV Infections;HIV Seronegativity;HIV vaccine;IL17 gene;Immune;immune activation;Immunologics;Immunology;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Inflammatory Response Pathway;intercellular cell adhesion molecule;Interferons;Intervention;Intestinal permeability;ITGB2 gene;Laboratories;Life;Maintenance;Mediation;men;men who have sex with men;Menopause;Menstruation;microbial;microbiome;microbiota;microbiota composition;Modeling;Molecular;monocyte;Mucositis;Mucous Membrane;Ovulation;participant enrollment;Pathology;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;pre-exposure prophylaxis;Pregnancy;Prevotella;programs;Public Health;recruit;rectal mucosa;Rectum;Reporting;reproductive;Research;Residual state;response;Risk;Serum;sex;sex as a biological variable;Sex Behavior;Sex Differences;Shapes;Supplementation;Synapses;systemic inflammatory response;Tissues;TLR4 gene;TNF gene;transcription factor NF-AT c3;transcriptome;transcriptomics;transmission process;United States National Institutes of Health;Up-Regulation;vaccine response;Variant;Viral;Viral Load result;Viral Pathogenesis;Viral reservoir;Woman;Women's mortality

PROJECT_TITLE: Defining Sex-Specific Systemic and Gut Inflammatory Profiles in People Living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE A conserved forebrain to midbrain pathway is involved in a plethora of neural functions, including circadian  activity, reward, decision making, anxiety and fear, and has been implicated in neurological disorders such  as depression, schizophrenia, and addiction. Understanding how this pathway develops the correct  connections between its specific neuronal populations, and how these populations differ on the left and right  sides of the brain, will help explain its diverse functions.

PI_NAMEs: HALPERN, MARNIE E (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: addiction;Address;Amphibia;Anxiety;Atlases;Attention;autism spectrum disorder;Axon;Behavior;Behavioral;Behavioral Assay;behavioral outcome;behavioral response;Bilateral;Biological Assay;Brain;Brain region;Calcium;calcium indicator;Calcium Signaling;Cell Nucleus;Cell Separation;cell type;Cells;cholinergic;circadian;confocal imaging;Coupled;CRISPR/Cas technology;Cues;Data;Data Set;Decision Making;Development;diencephalon;Dorsal;Dyslexia;experimental study;feeding;Fishes;Freezing;Fright;Functional disorder;Funding;Future;Gene Expression Profiling;Genes;Genetic;genome editing;Genomics;Goals;Habenular Nucleus;Human;Image;in vivo;information processing;innovation;interest;interpeduncular nucleus;Label;Learning;Left;Locomotion;Mammals;Maps;Mediating;Mental Depression;Midbrain structure;Modeling;Molecular;Monitor;Mood Disorders;Motivation;multi-photon;Nervous System Disorder;neural circuit;Neural Conduction;Neural Pathways;neuroimaging;Neurologic;Neurons;Neuropeptides;Neurophysiology - biologic function;Neurosciences Research;Neurotoxins;Neurotransmitters;Nicotine Dependence;Nicotine Withdrawal;optogenetics;Pain;Pathologic;Pathway interactions;Physiological;Population;postsynaptic;presynaptic;Presynaptic Terminals;Process;Progress Reports;Property;Prosencephalon;Reagent;real-time images;Reproduction;Reptiles;Research;Resources;response;Rewards;Role;Sample Size;Schizophrenia;Side;Signal Transduction;Sleep;Stimulus;System;Time;Tissues;tool;Transgenic Organisms;Vertebrates;Withdrawal Symptom;Work;Zebrafish

PROJECT_TITLE: Connectivity and Function of the Asymmetric Habenulo-Interpeduncular Pathway


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Nurturing and cultivating a diverse workforce dedicated in the research and education of dental, oral, and craniofacial medicine is essential for building a diverse and capable oral health profession, and elimination of disparity in oral health. The proposed Maryland Program in Dental Research Experience (D-REX) is aimed at cultivating the interest in oral health research in a diverse group of highly motivated high school and undergraduate students, and inspiring them to pursue a career in academic dentistry.

PI_NAMEs: REN, HENING  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Aging;Area;Awareness;Baltimore;Biocompatible Materials;Biological Sciences;Biology;bone;career;Career Choice;Cities;Collaborations;Communicable Diseases;Country;County;craniofacial;Dedications;Dental;Dental Education;Dental Research;Dental Schools;Dental Students;Dentistry;Dentists;design;disparity elimination;Diverse Workforce;Education;Educational process of instructing;Educational workshop;empowerment;Environment;Epidemiology;Evaluation;experience;Faculty;faculty mentor;field trip;Fostering;Foundations;Funding;Future;Future Teacher;Goals;hands on research;Health;Health Care Research;health disparity;Health Occupations;Health Sciences;Healthcare;high school;High School Faculty;High School Student;Historically Black Colleges and Universities;improved;Institution;interest;International;Internships;Laboratories;lectures;Malignant Neoplasms;Maryland;Medical;Medicine;member;Mentors;microbial;Mission;Motivation;National Institute of Dental and Craniofacial Research;Neurosciences;next generation;Oral;Oral health;Pain;Participant;Pathogenesis;Personal Satisfaction;Population;Productivity;programs;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Risk;Running;Scholars Program;School Dentistry;Science;science education;science teacher;Science, Technology, Engineering and Mathematics Education;skills;Structure;Student recruitment;Students;Subgroup;summer research;System;teacher;Teenagers;Time;Tissue Engineering;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underserved Population;United States National Institutes of Health;Universities


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed work will investigate SQLE, as well as SQLE-regulated sterols, as novel players in the survival disparity observed in patients with ER+ breast cancer. This work has the potential to increase health equity by improving survival for AA women with ER+ breast cancer through the development of novel preventive and treatment strategies that target underlying molecular mechanisms contributing to disparate outcomes.

PI_NAMEs: COLOFF, JONATHAN L. (contact);HOSKINS, KENT

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: 8q24;African American;African American Women;Area;Aromatase Inhibitors;Automobile Driving;Binding;Biological;Breast Cancer Model;Breast Cancer Patient;breast cancer survival;cancer type;Cell Physiology;Cell Proliferation;Cell Survival;Cell Therapy;Cessation of life;Chicago;Cholesterol;Chromosomes;cohort;Collection;Data;Development;Diagnosis;Disease;Enzymes;epoxidase;Epoxy Compounds;Estrogen receptor positive;Estrogen Receptors;Estrogens;Freezing;Genomics;Goals;health equity;hormone therapy;improved;Incidence;inhibitor;innovation;insight;Malignant Breast Neoplasm;Mammary Neoplasms;Messenger RNA;Methods;Molecular;mortality risk;mRNA Expression;Normal tissue morphology;Not Hispanic or Latino;novel;Organoids;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;Pre-Clinical Model;Prevention strategy;Production;Prognosis;Prognostic Factor;protein expression;Race;racial disparity;racial diversity;Recurrence;Relapse;relapse risk;Resistance;response;Risk;Role;Squalene;Stage at Diagnosis;statistics;Sterol Biosynthesis Pathway;Sterols;survival disparity;Survival Rate;Tamoxifen;targeted treatment;Testing;therapeutic target;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Promotion;Tumor Subtype;Up-Regulation;White Women;Woman;Women's mortality;Work

PROJECT_TITLE: SQLE and Sterols Contribute to Racial Disparity in ER+ Breast Cancer Patient Survival

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ORG_CITY: DALLAS

ORG_DEPT: BIOLOGY

ORG_NAME: SOUTHERN METHODIST UNIVERSITY

PHR: People with epilepsy are 16 times more likely than the general population to die suddenly for unexplained pathological reasons. These deaths are classified as sudden unexpected death in epilepsy (SUDEP), the leading cause of epilepsy-related mortality, but predictive biomarkers of SUDEP are lacking, which hinders accurate patient risk stratification and prevention. This proposal uses a new multidisciplinary bioengineering systems approach to identify pathological functional interactions between the brain, heart, and lungs in potassium and sodium channelopathy mouse models of SUDEP that could serve as new and more reliable biomarkers for monitoring SUDEP risk and disease progression in epilepsy patients.

PI_NAMEs: GLASSCOCK, ALBERT E (contact);JASSEMIDIS, LEONIDAS D

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Afferent Pathways;Animal Model;Autonomic nervous system;Benchmarking;Biological;Biological Markers;Biomedical Engineering;Brain;brain abnormalities;brain dysfunction;candidate identification;candidate marker;Cardiac;Cessation of life;Classification;clinical application;conditional knockout;Development;Disease Progression;Efferent Pathways;Electrocardiogram;Electroencephalography;Epilepsy;Evaluation;Exhibits;Foundations;Frequencies;Functional disorder;Future;gain of function mutation;General Population;Genetic;Goals;Heart;Impairment;insight;Intervention;Knock-out;knockout animal;knockout gene;Knockout Mice;Light;Lung;Measurement;Measures;Mediating;Methods;Modeling;Monitor;mortality;mouse model;multidisciplinary;Mus;Myocardial dysfunction;National Institute of Neurological Disorders and Stroke;Nature;Neurons;novel marker;Organ;Pathologic;Pathway interactions;Patient risk;Patients;Pattern;Persons;pharmacologic;Pharmacology;Phenobarbital;Play;Plethysmography;Potassium;predictive marker;Predisposition;Prevention;Prevention strategy;Publishing;Research;Risk;Risk Assessment;risk prediction;risk stratification;Role;SCN8A gene;Seizures;Sodium;sudden unexpected death in epilepsy;System;Techniques;Testing;Time;translational potential;Ventilatory Depression;Work

PROJECT_TITLE: Biomarkers of SUDEP risk based on brain-heart-lungs network dynamics

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Sleep Research

PHR: Project Narrative We will investigate whether heart rate response, a novel marker of obstructive sleep apnea (OSA) severity, improves risk prediction of incident AF. We will also develop a deep learning model incorporating awake and sleep electrocardiography to predict incident AF among people with OSA. Both observational cohort and clinical data will be used for this purpose.

PI_NAMEs: AKBILGIC, OGUZ ;AZARBARZIN, ALI ;KWON, YOUNGHOON  (contact)

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Ablation;Academic Medical Centers;Affect;Anticoagulation;Apnea;Arrhythmia;Atherosclerosis Risk in Communities;Atrial Fibrillation;awake;Cardiac health;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Clinical;Clinical Data;clinical practice;Clinical Trials;cohort;Cohort Studies;Communities;convolutional neural network;Data;Data Set;Decision Making;deep learning;deep learning model;design;Detection;Development;diagnostic tool;efficacy testing;Elderly man;Electrocardiogram;Electrophysiology (science);Evaluation;Event;Future;General Population;Heart;Heart Atrium;heart electrical activity;Heart Rate;Hypertension;improved;improvement on sleep;indexing;Individual;Ischemic Stroke;Lead;Link;Maps;Mechanics;modifiable risk;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Neural Network Simulation;novel;novel marker;Obesity;Obstructive Sleep Apnea;Oral;Outcome;Pathologic;Patients;Pattern;Performance;personalized approach;Persons;Physiological;Polysomnography;Population;predictive modeling;Predictive Value;Predisposition;prevent;Property;Prospective cohort;Recurrence;Respiration;response;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk sharing;risk stratification;screening;Severities;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Stretching;Testing;Therapeutic;Training;United States;Universities;Validation;Virginia

PROJECT_TITLE: Deep learning of awake and sleep electrocardiography to identify atrial fibrillation risk in sleep apnea

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Toxoplasma gondii is a parasite that causes life-threatening opportunistic infection in HIV/AIDS patients for which safer and more effective therapies are urgently needed. We have identified an essential system of mRNA modification in Toxoplasma that is composed of plant-like components. The goal of this proposal is to determine how these mRNA modification signals operate in parasite replication and development into latent tissue cysts, which promises to reveal important vulnerabilities that could be targeted by new drugs to combat AIDS- toxoplasmosis.

PI_NAMEs: SULLIVAN, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Adenosine;Antiparasitic Agents;Binding;Binding Proteins;Binding Sites;Biology;Cell Nucleus;Chronic Disease;Cleavage And Polyadenylation Specificity Factor;combat;Comprehension;crosslink;Cyst;Cytosol;Data;Development;effective therapy;epitranscriptomics;Family;Felis catus;Follow-Up Studies;Food Contamination;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;HIV/AIDS;Human;Hybrids;Immune response;Immunity;Immunocompromised Host;Immunoprecipitation;Individual;Infection;insight;knock-down;Knowledge;Life;Mediating;Messenger RNA;Metabolism;Methylation;Modification;Mutation Analysis;new therapeutic target;novel;novel therapeutics;Nuclear;Nuclear Export;Opportunistic Infections;opportunistic pathogen;Parasites;Patients;Pharmaceutical Preparations;Phenotype;Plants;polyadenylated messenger RNA;Population;Positioning Attribute;Process;Proliferating;Proteins;Reader;recruit;Recurrence;RNA;RNA Probes;RNA Splicing;Role;Signal Transduction;System;Tertiary Protein Structure;therapeutic target;Time;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;trafficking;Transcript;transcriptome;Translations;transmission process;Untranslated Regions;Water;Writing;Zinc Fingers

PROJECT_TITLE: m6A mRNA reader proteins in the AIDS-opportunistic pathogen Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Primary and secondary (metastases) brain tumors are amongst the most lethal forms of cancer; the finding that cancer integration into neural circuitry drives tumor progression opens numerous doors to a deeper understanding of the role the nervous system plays in disease. Here, we investigate the broad crosstalk between dynamic neuronal circuits from differing regions in the brain that may collectively instruct primary and secondary brain tumor growth. Neuron-tumor interactions, including electrical cues from differing neuronal subpopulations, neuron-cancer circuit dynamics, and subsequent signaling in tumor cells, thus represent a novel set of therapeutic targets for this group of devastating cancers.

PI_NAMEs: VENKATESH, HUMSA  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: advanced system;Affect;AMPA Receptors;Behavior;Benzodiazepines;Bioinformatics;Brain;Brain Neoplasms;Calcium;cancer cell;Cancer Etiology;cancer site;cancer therapy;career development;Cell Communication;Cells;Cessation of life;Clinical;Communication;Complex;Coupled;Cues;Data;Dependence;Development;Disease;Disease Progression;Disseminated Malignant Neoplasm;Distal;dopaminergic neuron;Electroencephalography;Electron Microscopy;Electrophysiology (science);Equilibrium;experimental study;Feedback;Fiber;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;Genes;Genetic;genetic manipulation;Glioma;glutamatergic signaling;Glutamates;Growth;Growth Factor;Heterogeneity;hippocampal pyramidal neuron;Histologic;Histology;Image;Imaging Techniques;improved outcome;in vivo;in vivo imaging system;Incidence;Infiltration;insight;Interneurons;Label;Location;Lung;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediating;Membrane;Metastatic malignant neoplasm to brain;Molecular;Monitor;Mus;Nature;Neoplasm Metastasis;neoplastic cell;nerve stem cell;Nervous System;neural;neural circuit;neural network;neurodevelopment;Neuroendocrine Cell;neuroligin 3;neuronal circuitry;neuronal excitability;Neuronal Plasticity;neuronal tumor;Neurons;neuroregulation;Neurosciences;neurotransmission;novel;novel therapeutic intervention;Oncogenic;Oncology;optogenetics;Pathway interactions;Patient-Focused Outcomes;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Photometry;PI3K/AKT;Play;Population;postsynaptic;Regulation;residence;Role;Signal Pathway;Signal Transduction;small cell lung carcinoma;spatiotemporal;Synapses;Techniques;therapeutic target;Time;Tissues;Training;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Microenvironment-driven electrical regulation of primary and secondary brain tumor progression

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is an autoimmune neurological disease affecting nearly 1 million people in the United States and is the most common cause of disability in young adults. MS is highly associated to Epstein-Barr virus (EBV), but the mechanisms underlying MS are poorly understood. Success of the proposed studies would explain the connection between EBV and MS on a molecular level and could lead to transformative and fundamental treatment approaches focused on preventing or treating EBV rather than non-specifically depleting B cells or inhibiting immune cell trafficking.

PI_NAMEs: LANZ, TOBIAS VOLKER;ROBINSON, WILLIAM H (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;Antibody Repertoire;Antigen Targeting;Antigen-Presenting Cells;Autoantibodies;Autoantigens;Autoimmune Diseases of the Nervous System;autoreactive T cell;B cell repertoire;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Bioinformatics;Cell Adhesion;Cell Adhesion Molecules;cell transformation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinical;cohort;Development;differential expression;disability;Disease;disorder subtype;Epidemiology;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Human;Human Herpesvirus 4;Immune;Individual;Infection;Investigation;Measures;Mediating;MicroRNAs;Molecular;Molecular Mimicry;Monoclonal Antibodies;Multiple Sclerosis;multiple sclerosis patient;Myelin;neuroinflammation;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Persons;Prevalence;prevent;Production;Proteome;Role;Serology;single-cell RNA sequencing;Specificity;success;synergism;System;T cell response;T-Cell Activation;T-Lymphocyte;targeted sequencing;Testing;trafficking;transcription factor;transcriptome;transforming virus;United States;young adult

PROJECT_TITLE: Deciphering the Role of Epstein-Barr Virus Molecular Mimicry and B cell Transformation in Multiple Sclerosis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Nearly 40 million people are infected with HIV, an infection for which we do not have a cure. In this proposal, we seek to identify the properties of T cells that make them better able to kill cells infected with HIV. Our ultimate goal is to find strategies to harness these properties in order to improve future T cell-based therapies to cure HIV.

PI_NAMEs: RUTISHAUSER, RACHEL LENA (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Aftercare;Animal Model;Antigens;antiretroviral therapy;Autologous;Bar Codes;Basic Science;Blood specimen;Cancer Control;CAR T cell therapy;CD8-Positive T-Lymphocytes;cell killing;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Clinical;Clinical Trials;Collaborations;Cytometry;cytotoxic;Development;Disease;Effector Cell;effector T cell;exhaust;exhaustion;experience;Funding;Future;Gene Expression Profiling;Genetic Engineering;Genetic Transcription;Goals;high dimensionality;HIV;HIV Infections;Human;Human Engineering;improved;In Vitro;in vivo;Individual;Infection;Infusion procedures;Interruption;Intervention;Knowledge;Literature;lymph nodes;Lymphoid Tissue;Macaca;Malignant Neoplasms;Mediating;Memory;MHC Class I Genes;migration;Modeling;mouse model;multimodality;Mus;overexpression;Participant;PD-1 blockade;Peptides;peripheral blood;Persons;Phenotype;Population;programs;Proliferating;Property;Protocols documentation;response;Role;Sampling;single-cell RNA sequencing;SIV;Sorting;Stains;stem;stem cells;stem-like cell;stemness;T cell differentiation;T cell receptor repertoire sequencing;T cell therapy;T-Lymphocyte;Testing;Time;Tissue Sample;Tissues;Toxic effect;transcription factor;Vaccine Therapy;Viral;viral rebound;Virus;Xenograft procedure

PROJECT_TITLE: Targeting HIV-specific T cell differentiation programs to enhance post-treatment control of HIV

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Nearly half of patients do not recover following the first line of treatment for OCD, exposure and response prevention (ERP). This study proposes to test a novel method of augmenting ERP, a computerized, scalable intervention targeting interpretation bias, which is a critical mechanism underlying OCD. The overall goal is to contribute to the development of technology-driven augmentations to ERP to enhance response rates, which may generalize to treatment for other OC-related and anxiety disorders in the future.

PI_NAMEs: FALKENSTEIN, MARTHA J (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adherence;Adult;analog;Anxiety;Anxiety Disorders;Area;Award;Behavioral;Benchmarking;career development;Characteristics;Clinical;Clinical Treatment;Clinical Trials;Cognitive;computerized;Dangerousness;Data;Development;Diagnostic;Disease;dosage;Ecological momentary assessment;effective therapy;effectiveness trial;Exposure to;feasibility testing;follow-up;Future;Goals;implementation evaluation;improved;improved outcome;Individual;innovation;Intervention;Interviewer;Investigational Therapies;kernel methods;Learning;Machine Learning;Maintenance;Maps;Measures;Mediating;Mental Processes;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Modeling;Modification;multimodality;novel;Obsession;Obsessive-Compulsive Disorder;Outcome;Participant;patient oriented research;Patients;personalized predictions;Population;Preparation;Prevention;Probability;programs;Psychiatric Hospitals;psychoeducation;Randomized;recruit;reduce symptoms;Refractory;Relapse;Research;Research Personnel;response;Sampling;Sensitivity and Specificity;Severities;skills;Stimulus;Symptoms;Techniques;Technology;technology development;Testing;Training;treatment as prevention;treatment program;treatment response;Work;Youth

PROJECT_TITLE: Interpretation Bias as a Mechanism of Treatment Response in OCD


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Toxoplasma gondii is a widespread human pathogen that can cause life-threatening infection in the developing fetus and in people who are immunocompromised due to AIDS, chemotherapy or organ transplantation. This project will increase our understanding of how the parasite delivers proteins that are important to its ability to cause disease into the cells of its host during infection. A better understanding of this process will provide new opportunities for the development of drugs to treat the devastating disease caused by these parasites.

PI_NAMEs: WARD, GARY E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Adverse effects;American;Apical;Apicomplexa;Bioinformatics;Biological;Biological Assay;Biological Process;Biology;Calcium;calcium indicator;Cell membrane;Cells;Cellular biology;chemotherapy;cost;Cryptosporidiosis;Cryptosporidium;Cytosol;Data;Development;Disease;drug development;Electric Conductivity;Erythrocytes;Event;Exocytosis;exosome;experience;extracellular;fascinate;Fetal Development;Fluo 4;Fluorescence Microscopy;Gene Expression;genetic approach;Goals;human pathogen;Immune;Immunocompromised Host;Immunofluorescence Microscopy;improved;Individual;Infection;Injections;Invaded;Knowledge;Life;Life Cycle Stages;Lipid Bilayers;Malaria;Membrane;Methods;Nature;Needles;novel;novel strategies;novel therapeutic intervention;Organ Transplantation;Organelles;parasite invasion;Parasites;patch clamp;Pathogenesis;Pathogenicity;Perforation;Persons;Pharmaceutical Preparations;Plasma Cells;Plasmodium;Play;Population;prevent;Process;Protein translocation;Proteins;reverse genetics;rhoptry;Role;Speed;Testing;therapeutic development;Toxoplasma gondii;Toxoplasmosis;virtual;Virulence;Virulence Factors;Visualization

PROJECT_TITLE: Host cell membrane perforation during invasion by Toxoplasma gondii

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


PHR: This study is to advance the understanding on the effects of drug resistance mutations and naturally occurring polymorphisms in regions other than the reverse transcriptase or protease in non-B subtype HIV-1 strains

PI_NAMEs: CHARURAT, MANHATTAN E;NDEMBI, NICAISE  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Address;Adherence;Affect;Africa;Anti-Retroviral Agents;Anti-retroviral drug resistance;Archives;Area;Binding;Biological Assay;Cameroon;case control;Cells;Clinical;clinically significant;Cloning;Code;cohort;Coupled;Data;design;Drug resistance;Drug resistance pathway;drug resistant virus;env Genes;Epidemiology;Evolution;Failure;fitness;Future;GAG Gene;Genes;Genetic;Genetic Polymorphism;Genetic Recombination;Genetic Variation;Genomic Segment;Genotype;Goals;HIV;HIV drug resistance;HIV Infections;HIV resistance;HIV-1;HIV-1 drug resistance;Human;improved;In Vitro;Infection;Infrastructure;inhibitor;Integrase;Laboratories;Link;Longitudinal cohort;Measures;Mediating;Methods;Modification;Multi-Drug Resistance;mutant;Mutation;Nested Case-Control Study;next generation sequencing;Nigeria;Nigerian;non-nucleoside reverse transcriptase inhibitors;novel;Outcome;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacotherapy;Pharmacy facility;Phenotype;Plasma;pol genes;Poland;Predictive Factor;Predisposition;Protease Inhibitor;Public Health;public health research;Publications;recombinant virus;Recombinants;Regimen;Reporting;Research;Research Design;Research Personnel;Resistance;resistance mutation;response;Risk;RNA;RNA-Directed DNA Polymerase;Role;Sampling;Site-Directed Mutagenesis;Specimen;success;System;Testing;transmission process;Treatment Failure;Uganda;Variant;Viral;Viral Genome;virology;Virus;Virus Replication;Yeasts

PROJECT_TITLE: Impact of Non - B HIV - 1 Subtype on second line Protease Inhibitor Regimens in Africa (INSPIRE)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Data Science;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: REWIRE NEUROSCIENCE, LLC

ORG_STATE: OR

PHR: PROJECT NARRATIVE Over 100 drugs can cause hearing loss, yet there are few technological solutions to detect the potential for new drugs to impact hearing. We have developed machine learning technology to predict drug-induced hearing loss. We will further optimize our technology to improve performance, then validate the technology in an animal model. Our goal is to improve safety during the drug development process by ruling out drugs that can cause hearing damage before they impact patients.

PI_NAMEs: HARKNESS, JOHN H (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Algorithms;Animal Model;Artificial Intelligence;Bacterial Infections;Capital;Cardiotoxicity;Case Study;Categories;Cause of Death;Chemical Structure;Chemicals;Clinical;Clinical Trials;commercialization;cost;cost effective;COVID-19;Data;Data Set;Databases;Development;Disease;Drug Costs;drug development;Ear;experience;FDA approved;feature selection;Future;Goals;Hair Cells;Hearing;hearing impairment;Hearing problem;Hydroxychloroquine;improved;in vivo;Individual;Inner Hair Cells;innovation;Investments;Ivermectin;large datasets;lateral line;Lead;Link;Machine Learning;machine learning algorithm;machine learning model;Malignant Childhood Neoplasm;Methods;Modeling;Molecular;National Institute on Deafness and Other Communication Disorders;novel;novel therapeutics;older patient;Organ;ototoxicity;ototoxin;Output;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Positioning Attribute;pre-clinical;Preclinical Drug Development;predictive modeling;prevent;Principal Component Analysis;Process;Publishing;Reporting;Research;research clinical testing;Research Contracts;Safety;Sensorineural Hearing Loss;Sensory;Sensory Hair;service learning;Services;side effect;Small Business Technology Transfer Research;small molecule;Strategic Planning;success;supervised learning;Supporting Cell;Synapses;System;Technology;technology validation;Testing;Time;Toxic effect;training data;transfer learning;unsupervised learning;user-friendly;Validation;web portal;Zebrafish

PROJECT_TITLE: Development and in vivo validation of a machine learning platform to predict ototoxic potential of pharmaceuticals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Cardiovascular disease (CVD) is the most common cause of death in Veterans. CVD-related deaths are over twice as likely in patients with comorbid alcohol misuse, due in part to alcohol misuse directly exacerbating several modifiable factors that lead to CVD. 9-32% of all Veterans are in this high-risk, preventable population of comorbid alcohol misuse and elevated, modifiable CVD risk. No treatments have targeted this population. Current VA/DoD treatment guidelines for comorbid alcohol misuse in primary care are ineffective. Because alcohol misuse is often a recurrent problem, and the dominant driver of treatment recommendations, timely treatment of these Veterans’ CVD risk in conjunction with alcohol misuse treatment in may be critical for developing clinical traction with CVD risk. This research is highly relevant to Veteran health, VHA priorities, and HSR&D priorities because the combined intervention targets and telehealth approaches address critical gaps in treatment timeliness and access for this high-risk population.

PI_NAMEs: BLALOCK, DANIEL V (contact)

PROJECT_TERMS: acceptability and feasibility;Address;alcohol comorbidity;alcohol intervention;alcohol misuse;alcohol screening;alcohol services;Alcohols;barrier to care;Behavior Therapy;Behavioral;behavioral health;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;career;Caring;Cause of Death;Cessation of life;Characteristics;Clinic;Clinical;Clinical Data;clinical effect;Clinical Trials;clinically significant;Cognitive Therapy;cohort;comorbidity;comparative effectiveness trial;cost effectiveness;Data;design;Development;Diet;drinking;Effectiveness;Electronic Health Record;Feedback;follow-up;Foundations;Funding;Future;Glean;Goals;Habits;Health;Health behavior;Health Services;Health Services Accessibility;Heavy Drinking;high risk;high risk population;implementation science;Improve Access;improved;innovation;Intervention;intervention effect;intervention refinement;Interview;Measures;medication compliance;Methodology;Methods;mHealth;mhealth interventions;military veteran;Modality;Modeling;modifiable risk;novel;operation;Outcome;Patient Preferences;Patients;Pattern;Perception;physical inactivity;Physicians;Population;Primary Care;primary outcome;Process;Provider;Randomized;Recommendation;recruit;Recurrence;Relapse;Research;Research Personnel;Risk Reduction;secondary outcome;service utilization;skills;Smoking;stakeholder perspectives;substance use;System;Target Populations;telehealth;telephone coaching;Testing;therapy development;Time;Traction;Training;treatment guidelines;Underserved Population;Veterans;Visit

PROJECT_TITLE: Telehealth Treatment of Veterans with Alcohol Misuse at Risk for Cardiovascular Disease

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


PHR: Low use of outpatient PC limits the potential impact of PC consult teams on Veteran quality of life and end of life care. The long term objective of this research program is to understand how PCCT program structure influences appropriate use of high quality outpatient PC and identify programmatic strategies to improve outcomes for seriously ill Veterans. The objective of the proposed CDA is to evaluate the determinants of PC implementation outcomes of adoption and reach by applying the Practical, Robust, Implementation and Sustainability Model (PRISM) for implementation research. The project falls within HSR&D priorities for 1) primary care practice and management of complex chronic diseases and 2) aging, long-term care, and caregiving. The project is congruent with efforts of Durham VA’s Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), which focuses on developing and testing models to preserve Veteran function and independence and on implementation science.

PI_NAMEs: KAUFMAN, BRYSTANA G. (contact)

PROJECT_TERMS: Acceleration;Adoption;Aging;Award;Businesses;care systems;career;Caregivers;caregiving;Caring;Case Study;Cessation of life;Characteristics;Chronic Disease;clinical practice;cognitive interview;Communities;comparative effectiveness study;compare effectiveness;Complex;Consult;Consultations;Data;design;Development;econometrics;Effectiveness;Eligibility Determination;end of life care;Ensure;experience;falls;Family;field survey;Geriatrics;Goals;health service use;Home;Hospitalization;implementation evaluation;implementation outcomes;implementation research;implementation science;improved;improved outcome;Infrastructure;innovation;Inpatients;Interview;Investments;Knowledge;Leadership;Learning;Life;Long-Term Care;Measures;Medical;member;Mentors;Methods;Modeling;multiple chronic conditions;operation;Outcome;Outpatients;Palliative Care;Pathway interactions;Patients;Pattern;Patterns of Care;Perception;Policies;Practical Robust Implementation and Sustainability Model;preservation;Primary Care;primary care practice;programs;psychosocial;Quality of Care;Quality of life;Quantitative Evaluations;Reporting;Research;Research Design;Research Personnel;Resources;satisfaction;Site;skills;Structure;Surveys;System;Telephone Interviews;Testing;Training;usability;Veterans;Work

PROJECT_TITLE: Outpatient Palliative Care Implementation to Improve Outcomes for AgingVeterans


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: This project is relevant to all aspects of VA healthcare for it will develop and evaluate a training toolkit to assist healthcare teams to change their culture toward learning to enhance Veteran care. This work will support the VA transformation to a learning health system, so clinicians can see every patient encounter as a way to make the next one better. This will be achieved through studying unit-level learning environments, identifying high- reliability practices that support a learning culture and using this knowledge to adapt a team training program to the culture and workflow of clinical units. We will develop and test a training toolkit to empower teams to de- velop their own culture of learning and a rigorous mixed methods evaluation that leads to valid, generalizable lessons applicable across healthcare settings. We expect this study to result in positive changes in learning environments, teamwork, and highly-reliable use of evidence-based practices. The findings will inform future studies to determine the impact of learning environments on Veteran outcomes.

PI_NAMEs: GILMARTIN, HEATHER M. (contact)

PROJECT_TERMS: Adopted;Adoption;Cardiac;Cardiac Catheterization Procedures;career;Caring;Case Study;Climate;Clinical;clinical care;clinical practice;Collection;Communication;Consensus;Coronary;Data;design;Development;Doctor of Philosophy;Education;educational atmosphere;Educational Models;Educational process of instructing;Elements;Employee Engagement;empowerment;Ensure;Environment;Evaluation;evidence base;Evidence based practice;experience;Feasibility Studies;feasibility testing;flexibility;Fostering;Future;Goals;Health;health care settings;Health Sciences;Health system;Healthcare;Healthcare Systems;implementation research;implementation science;innovation;insight;Institute of Medicine (U.S.);Investigation;Knowledge;Leadership;Learning;Life;Maintenance;Medical Care Team;Mentorship;Methodology;Methods;mindfulness;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Nurse Practitioners;Observational Study;Operative Surgical Procedures;Outcome;patient safety;Patients;pilot test;Population;post intervention;Procedures;programs;psychologic;Qualifying;Reporting;Research;Research Personnel;Resources;Safety;Sampling;scale up;Science;skills;Standardization;supportive environment;Surveys;Techniques;Testing;therapy design;Time;tool;Training;Training Programs;Translating;trend;Trust;Variant;Veterans;Veterans Health Administration;Work;Workplace

PROJECT_TITLE: Building Supportive Learning Environments: Implementation Research in VA Cardiac Cath Labs


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Remyelination failure in diseases such as multiple sclerosis is believed to lead to neurodegeneration and cumulative disability, but the mechanisms linking chronic demyelination to neuronal loss are unclear. Here, we propose to use genetic animal models to better understand how neurons respond to loss of glial and myelin support. These studies will lay the foundation to develop new strategies to promote neuronal resilience in the demyelinated human nervous system.

PI_NAMEs: EMERY, BEN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Address;Affect;Animal Genetics;Animal Model;Animals;Axon;axon injury;axonal degeneration;Cell Death;Cell Survival;Chronic;chronic demyelination;conditional knockout;Consensus;CRISPR/Cas technology;Data;Demyelinating Diseases;Demyelinations;designer receptors exclusively activated by designer drugs;disability;Disease;Electric Stimulation;Event;Failure;Foundations;Genes;Genetic;Genetic Models;Genetic Transcription;Human;Individual;Inflammation;Inflammatory;interest;JUN gene;Knockout Mice;Lesion;Link;Lipopolysaccharides;Maintenance;MAPK8 gene;Mediating;member;Metabolic;Metabolic stress;Modeling;Molecular;mouse genetics;mouse model;Mouse Strains;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Nerve Degeneration;Nervous System;Neuroglia;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprotection;neurotransmission;oligodendrocyte progenitor;Oligodendroglia;Optic Neuritis;Pathologic;Pathway interactions;Persons;pharmacologic;Population;Predisposition;Production;programs;Recovery;recruit;regenerative;remyelination;resilience;response;Retinal Ganglion Cells;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;stem cells;Stress;Subgroup;Synapses;System;Tamoxifen;transcription factor;transcriptome sequencing;Visual Pathways;Visual System;YY1 Transcription Factor

PROJECT_TITLE: Neuronal responses to chronic demyelination

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Disability Research;Genetics;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability with a lack of effective treatment strategies, and the poor IVD healing capacity requires new ways of thinking. This project uses a novel IVD regenerative healing model and innovative genetic and microscopy tools to identify cells and extracellular matrix microenvironment factors critical for enabling IVD healing and regeneration. Next, design criteria for cell delivery are identified and validated on human cells and tissues.

PI_NAMEs: IATRIDIS, JAMES C. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adult;Affect;Age;Aging;Anatomy;Atomic Force Microscopy;Back Pain;beta Aminopropionitrile;Biomechanics;Cell Maturation;Cell Proliferation;cell regeneration;Cell Therapy;Cells;Chronic;Clinical Trials;Collagen;crosslink;Data;Defect;density;Deposition;design;Diameter;disability;disability impact;discogenic pain;effective therapy;Engineering;Environment;ethylene glycol;Extracellular Matrix;Fibrosis;Functional disorder;Genetic;Growth;healing;Height;Human;improved;Inflammation;inhibitor;Injections;Injury;innovation;Integrins;Intervertebral disc structure;intervertebral disk degeneration;Ligands;Mechanics;Mediating;Microscopy;Mitosis;Modeling;Modulus;mouse model;Mus;nanoindentation;Natural regeneration;Neonatal;neonate;Nerve;neurovascular;novel;nucleus pulposus;old mice;Outcome;Pain;permissiveness;Phenotype;Play;Population;Population Heterogeneity;postmitotic;postnatal;Process;progenitor;Proliferating;Property;Protein-Lysine 6-Oxidase;Puncture procedure;recruit;Recurrence;regeneration potential;regenerative;Regenerative capacity;regenerative healing;Regenerative Medicine;regenerative repair;repair strategy;restoration;Role;scleraxis;single-cell RNA sequencing;standard care;stem cell population;Thinking;Time;Tissue Engineering;Tissues;tool;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Mechanisms for Regenerative Healing in Intervertebral Discs

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The goal of this proposal is to understand the molecular mechanisms by which a novel protective PD-1hi resident memory CD8 T cell (TRM) population is maintained. In addition, we will also determine whether it is possible to uncouple the pathogenic from protective activities of PD-1hi TRM so we may specifically provoke the protective, but not the pathogenic function of TRM for future vaccine design and/or immunotherapies

PI_NAMEs: SUN, JIE  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Ablation;Acute;Acute Disease;acute infection;Adopted;Adult;anti-PD-L1 therapy;antimicrobial;CD28 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cells;Child;Chronic;Clinical;Clinical Research;comparison control;Data;design;Development;Equilibrium;Etiology;exhaust;Exhibits;fibrotic lung;Future;Goals;Granzyme;Heterogeneity;Immunity;Immunology;Impairment;In Situ;Infection;Inflammation;influenza infection;Influenza Therapeutic;Influenza vaccination;influenza virus vaccine;influenzavirus;Injury;insight;Interferon Type II;Intervention;Lead;Left;Lung;Maintenance;Mediating;Memory;Molecular;Molecular Target;Morbidity - disease rate;mortality;novel;Parabiosis;pathogen;Pathogenicity;Pathologic;Patients;PD-L1 blockade;Persons;Population;Primary Infection;programmed cell death protein 1;Pulmonary Fibrosis;receptor;Recovery;Rejuvenation;Resolution;response;Role;Science;Signal Transduction;single-cell RNA sequencing;T cell response;Testing;therapeutic vaccine;tissue resident memory T cell;Tissues;TNF gene;transcription factor;Translating;Vaccine Design;vaccine immunotherapy;Viral Respiratory Tract Infection

PROJECT_TITLE: Balancing protective immunity and chronic sequelae by resident CD8 T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Obesity

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The evolutionary process influences the biological traits that define a species including common medical problems such as cancer and infectious disease. It remains extremely difficult to identify causal genetic changes that increase fitness of an individual. The goal of the McGrath laboratory is to understand the genetic basis of adaptation, using C. elegans as a model organism.

PI_NAMEs: MCGRATH, PATRICK T (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;American;Area;Behavior;Behavioral;Biological;Caenorhabditis elegans;Cells;Chromatin;Chromatin Remodeling Factor;Communicable Diseases;design;Development;DNA Sequence Alteration;Environment;Evolution;fitness;food consumption;Gene Expression;Genes;Genetic;Goals;Growth;Human;human disease;Individual;Laboratories;Malignant Neoplasms;Medical;Metabolism;model organism;Modeling;Mutation;Nematoda;neural circuit;Neurons;NURF;Obesity;Organism;pathogen;Phenotype;Pheromone;Predisposition;Process;Risk Factors;Sexual Reproduction;Signal Transduction;Social Behavior;trait;tumor progression;Work

PROJECT_TITLE: Identification and study of adaptive mutations and phenotypes using laboratory growth of C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Persons with Alzheimer’s disease and related dementias (ADRD) experience behavioral symptoms such as agitation, combativeness, depression, and apathy. These behaviors increase caregiver stress, which leads to negative outcomes, such as poor health, depression, and increased caregiver burden. This project seeks to develop and test an intervention to enhance active caregiver skill training to prepare caregivers to better manage behavioral symptoms in order to improve ADRD caregiver wellbeing.

PI_NAMEs: EATON, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;Affect;aging population;Agitation;Alzheimer's disease related dementia;American;Area;associated symptom;Behavior;Behavior Therapy;Behavioral Symptoms;career;career development;Caregiver Burden;caregiver education;caregiver interventions;caregiver stress;Caregiver well-being;Caregivers;caregiving;clinical research site;Clinical Trials;Cognitive;Complex;coping;Dementia;dementia care;Dementia caregivers;dementia caregiving;Discipline;Distal;Educational Intervention;effective intervention;Ensure;Evidence based intervention;experience;Family Caregiver;Focus Groups;Fostering;Funding;Goals;group intervention;Growth;Health;improved;improved outcome;Individual;Individual Differences;innovation;Intervention;Intervention Studies;Intervention Trial;Knowledge;Leadership;Mental Depression;Mentored Research Scientist Development Award;Mentors;Modeling;multisensory;older adult;Outcome;Participant;perceived stress;Personal Satisfaction;Persons;Pilot Projects;Play;Positioning Attribute;Preparation;Psychologist;Quality of life;Randomized;rate of change;Research;Research Personnel;Resources;Role;Series;skills;skills training;Stress;stress symptom;symptom management;Symptoms;Techniques;Testing;Time;Training;United States National Institutes of Health;Waiting Lists

PROJECT_TITLE: Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: This study will breach a gap in knowledge regarding the role Müller cells, the primary glial cell in retina, play in non-neovascular AMD pathology. This study will also identify what stimulates Müller cell migration and proliferation leading to subretinal membrane formation, which we have reported in eyes with geographic atrophy. By looking at how Müller cell changes in AMD affect other cells, including retinal pigment epithelial cells, these studies may identify novel therapeutic targets for treating AMD.

PI_NAMEs: EDWARDS, MALIA MICHELLE (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acute;Address;Affect;Age related macular degeneration;Amyloid beta-Protein;Anterior;Area;Atrophic;Blindness;Cell Communication;Cell Culture Techniques;Cell membrane;cell motility;Cell Proliferation;cell type;Cells;Cellular Morphology;Cicatrix;Complex;cytokine;Data;Developed Countries;Disease;Disease Progression;Drusen;Epithelial Cells;exosome;experimental study;extracellular vesicles;Exudative age-related macular degeneration;Eye;Functional disorder;Future;geographic atrophy;Geographic Locations;glial activation;Glial Fibrillary Acidic Protein;Glutamate-Ammonia Ligase;Glutamine;Homeostasis;Human;In Vitro;Incidence;Inflammation;Inflammatory;Ions;Knowledge;Life Expectancy;Membrane;Mesenchymal;Metabolic;migration;Modeling;Muller's cell;Neuroglia;neurotrophic factor;new therapeutic target;novel;oxidized lipid;Pathology;Phenotype;Photoreceptors;Play;prevent;Process;protein expression;Rattus;Reporting;Research;response;Retina;Retinal Diseases;retinal neuron;Role;sodium iodate;stem cell therapy;Stimulus;Structure of retinal pigment epithelium;Synapses;Testing;therapeutic target;Thick;tissue culture;tissue degeneration;Touch sensation;Transforming Growth Factor beta;Treatment Efficacy;vesicular release

PROJECT_TITLE: Muller cell activation and remodeling in AMD.

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Palliative Care;Prevention

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: Advanced cancer can lead to significant emotional distress for patients and partners and can adversely affect their relationships. Couples’ ability to communicate openly and effectively with each other about cancer-related concerns can improve their psychological adjustment and quality of their relationship, and may lead to better symptom management and goal-concordant care. This study will test the effects of an intervention designed to enhance couples’ ability to communicate effectively about important cancer-related concerns, delivered via videoconference and targeted to couples at risk for poor outcomes. If successful, we will have developed a brief, targeted, and scalable intervention that could be integrated into routine palliative care, resulting in better outcomes for both patients and their family caregivers.

PI_NAMEs: PORTER, LAURA S (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: acceptability and feasibility;Address;Advance Care Planning;advanced directive;Advanced Malignant Neoplasm;Affect;Aftercare;Back;Breast;Buffers;cancer diagnosis;Cancer Intervention;Cancer Patient;care outcomes;care providers;Caring;Clinical;clinical practice;commune;Communication;Communication difficulty;coping;Couples;Data;design;Development;Distress;Education;Educational Intervention;efficacy testing;Elements;Emergency department visit;Emotional;emotional distress;Family Caregiver;follow-up;Future;Goals;Health;Hospitalization;improved;Individual;innovation;Internet;Intervention;intervention delivery;intervention effect;intimate behavior;Lead;Life;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;multidisciplinary;Oncology;Outcome;Palliative Care;Participant;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pilot Projects;process evaluation;psychologic;Psychological adjustment;psychological distress;psychosocial;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;response;Risk;satisfaction;screening;skills training;symptom management;Symptoms;Tablet Computer;Testing;therapy design;Time;Translations;treatment effect;videoconference;Videoconferencing;women versus men

PROJECT_TITLE: Couple Communication Skills Training for Advanced Cancer

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurodegenerative;Neurosciences;Peripheral Neuropathy

ORG_DEPT: BIOPHYSICS

PHR: Peripheral and autonomic neuropathies degrade quality of life and are linked to autoimmune disease and prevalent in patients receiving chemotherapy, but few treatments exist to alleviate these conditions. Because our skin and internal organs are in constant motion, so are the sensory neurons embedded in these tissues. The proposed multidisciplinary experiments and integrated theoretical research exploits a simple genetic model to develop a comprehensive understanding of how mechanical force is detected by sensory neurons and how these same neurons bend without breaking, focusing on cytoskeletal structures like microtubules and spectrin that are conserved in humans and implicated in sensitivity to traumatic brain injury.

PI_NAMEs: GOODMAN, MIRIAM B (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Afferent Neurons;Animals;Autoimmune Diseases;autonomic neuropathy;Biophysics;Caenorhabditis elegans;Calcium;cantilever;Chemicals;chemotherapy;Cytoskeleton;Diabetes Mellitus;Dissection;Electron Microscopy;Electrophysiology (science);Encapsulated;Engineering;experimental study;Feedback;Genetic;Genetic Models;Glucose;Health;Human;Image;Invertebrates;Joints;Knowledge;Link;mechanical force;mechanical signal;mechanical stimulus;Mechanics;Microtubules;Molecular;Monitor;Morphology;Motion;Movement;multidisciplinary;Muscle;Nematoda;Neurons;Optics;Organ;Paclitaxel;Patients;Perception;Performance;Peripheral Nervous System Diseases;programs;Quality of life;Research;Signal Transduction;simulation;Skin;somatosensory;Spectrin;Stress;stressor;Structure;Surface;Tactile;theories;Tissues;tool;Touch sensation;Translating;Traumatic Brain Injury;Visceral;Work

PROJECT_TITLE: The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress


ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH  Integrin dysfunction has been linked to severe health conditions such as thrombotic disorders, cardiovascular diseases, and inflammatory diseases. We proposed to elucidate regulatory mechanisms in integrin signaling in a species-specific manner and to develop peptidomimetic inhibitors that target the activator molecule of integrin. Our study will offer new insights into the integrin signaling mechanisms and a new class of integrin inhibitors by suppressing the activity of an intracellular integrin activator.

PI_NAMEs: WU, JINHUA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adaptor Signaling Protein;Autoimmune Diseases;Basic Science;Cardiovascular Diseases;Cell Adhesion;Cell Adhesion Molecules;Cell membrane;cell motility;Data;Defect;Development;Disease;Event;Functional disorder;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Inflammatory;inhibitor;insight;Integrins;interest;Laboratories;Link;Mediating;Molecular;molecular modeling;Monomeric GTP-Binding Proteins;peptidomimetics;Post-Translational Protein Processing;programs;Protein Isoforms;Proteins;Public Health;Regulation;Research;Signal Pathway;Signal Transduction;Specificity;T-Cell Proliferation;Therapeutic;Therapeutic Intervention;therapeutically effective;Thrombosis;Translational Research

PROJECT_TITLE: Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

PHR: Our previous and preliminary studies have identified aging related genes as important players for regulating axon regeneration. The proposed study will determine the roles of several of these genes in promoting optic nerve regeneration and identify novel aging regulatory genes that can be targeted to promote optic nerve regeneration using RNA-seq/ATAC-seq with advanced bioinformatics analyses. The result will not only reveal novel molecular mechanisms underlying mammalian axon regeneration, but also identify new and effective molecular targets for enhancing optic nerve regeneration.

PI_NAMEs: WAN, MEI  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: age effect;Aging;aging gene;aging mechanism;aging related;aging reversal;ATAC-seq;Axon;axon growth;axon injury;axon regeneration;Bioinformatics;Biomedical Research;Blood Vessels;Brain;c-myc Genes;Caenorhabditis elegans;Catalytic Domain;Cell Aging;cell regeneration;Cell Reprogramming;Cells;Central Nervous System;Chromatin;Chromosome Fragility;Consensus;Corticospinal Tracts;Cytoskeleton;Data;designer receptors exclusively activated by designer drugs;detection of nutrient;Development;DNA Repair;Enzymes;Epigenetic Process;Evolution;experimental study;Failure;FOXO3A gene;FRAP1 gene;gene repression;Genes;genetic manipulation;Genetic Techniques;Genetic Transcription;Genomic Instability;hallmarks of aging;Heterochromatin;histone methylation;Histones;human disease;IGF-1 Signaling Pathway;in vivo regeneration;induced pluripotent stem cell;inhibitor;innovation;insight;Insulin;Insulin-Like Growth Factor I;Knock-out;Longevity;Lysine;Mediating;Methylation;Molecular;Molecular Target;Myosin Type II;Natural regeneration;Nerve Regeneration;neural;Neurodegenerative Disorders;Neurons;Noise;Nonmuscle Myosin Type IIA;novel;Nutrient;Optic Nerve;Optic Nerve Injuries;optic nerve regeneration;overexpression;Pathway interactions;PIK3CG gene;Process;Production;Protocols documentation;Publishing;Regenerative capacity;Regulation;Regulator Genes;Regulatory Pathway;Rejuvenation;Retinal Ganglion Cells;RNA-Directed DNA Polymerase;Role;screening;sensor;Sensory;Signal Transduction;SIRT1 gene;SOX11 gene;Spinal cord injury;spinal cord regeneration;STK11 gene;Telomerase;Telomere Shortening;TP53 gene;transcription factor;transcriptome sequencing;transcriptomics;Traumatic Brain Injury

PROJECT_TITLE: Targeting aging genes and pathways to promote optic nerve regeneration


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Aging is commonly associated with visceral obesity, insulin resistance, and also increased inflammation. Our project proposes to study the role and mechanisms of adipose tissue inflammation in visceral obesity and insulin resistance associated with aging. Knowledge gained from our studies may help develop novel therapies for age-associated inflammation and metabolic disease.

PI_NAMEs: WU, HUAIZHU  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Age;age related;Aging;aging related;Biological Assay;Brown Fat;Cells;Central obesity;Clinical;Data;Diet;dietary;Disease;Energy Metabolism;Fatty acid glycerol esters;Flow Cytometry;Functional disorder;Human;immune activation;Impairment;improved;Inflammaging;Inflammation;inhibitor;Insulin Resistance;insulin sensitivity;Knockout Mice;Knowledge;Link;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;middle age;mouse model;Mus;novel;novel therapeutics;Obesity;Oleic Acids;Organ;Pathway interactions;pharmacologic;Phosphorylation;Pilot Projects;Play;prevent;Regulation;Regulatory T-Lymphocyte;Reporting;Repression;Role;Signal Transduction;Specimen;STAT1 gene;T cell therapy;T-cell inflamed;T-Cell Proliferation;T-Lymphocyte;Techniques;Testing;Thinness;tissue culture;Tissues;transcription factor;transcriptome sequencing;Visceral;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Inflammation and insulin resistance in aging

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]