NIH_SPENDING_CATS: Cancer;Pediatric

PHR: PROJECT NARRATIVE Per PAR-21-321 instructions, this component is not required.

PI_NAMEs: CONNOR, PETER  (contact)

PROJECT_TERMS: 20 year old;Accountability;Adoption;Agreement;anti-cancer research;Applications Grants;Appointment;Area;Award;biobank;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer genomics;Cancer Intervention and Surveillance Modeling Network;Career Choice;cBioPortal;Clinic;Clinical Research;Clinical Trials;Cloud Service;cohort;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Complex;Comprehensive Cancer Center;Consent;Consumption;Contracts;COVID-19;dashboard;Data;Databases;design;Development;Disease;diversity and equity;Education;Ensure;Environment;Equity;Evaluation;Feeds;Fostering;Funding;Future;genomic data;Goals;Grant;Health;Health Surveys;Healthcare;Hospitals;Human Resources;improved;Informatics;Information Systems;Infrastructure;innovation;Instruction;Intake;Internships;Investments;Lead;Leadership;Logic;Malignant Neoplasms;Marketing;Measurable;Mediation;meetings;member;Mission;Modeling;Monitor;multidisciplinary;Oncology;operation;organizational structure;Outcome Measure;outreach;Patients;Population Sciences;precision medicine;Process;Professional Education;prospective;Protocols documentation;Research;Research Infrastructure;Resource Sharing;Resources;Role;Schools;service member;Services;Site;Strategic Planning;System;Time;tool;Training;Translational Research;treatment planning;Universities;Vendor;Vision;Wisconsin;Work

PROJECT_TITLE: Cancer Center Administration


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Intracranial bleeding causes the highest rates of long-term disability and death among the different types of stroke. While intracranial bleeding can happen spontaneously, it is also a well-known feature of severe traumatic brain injury (TBI), which has become the signature wound of military operations and training over the last twenty years. In addition, TBI has become more common among older veterans, primarily due to falls, where it results in particularly poor clinical outcomes. Unfortunately, proven treatments for TBI and intracranial bleeding are lacking. An improved understanding of procoagulant platelet biology including the nature and regulation of platelet-Factor VIIa binding interactions is critical to improving patient outcomes and reducing health care costs for veterans with intracranial bleeding due to stroke or severe TBI. When completed, our scientific objectives have the potential to directly facilitate the development of new treatment strategies to address this significant unmet clinical need.

PI_NAMEs: FAGER, AMMON M (contact)

PROJECT_TERMS: activated protein C receptor;Address;Affect;Afghanistan;Alpha Granule;American;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Binding;Binding Sites;Biological Assay;Biology;Blood Platelets;Brain hemorrhage;Cell Culture Techniques;Cerebral perfusion pressure;Cessation of life;Chemicals;Chimera organism;Clinical;Complex;Confocal Microscopy;cost;Critical Care;crosslink;Cytoprotection;Data;Death Rate;design;Development;Diffuse;Dose;Emergency Situation;enzyme activity;Exhibits;Factor VIIa;falls;Goals;Growth;Health Care Costs;Hematoma;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;insight;Intervention;Intracranial Hemorrhages;Iraq;Knowledge;Life;Long term disability;Medical;meetings;Membrane Proteins;Microvascular Dysfunction;military operation;military service;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Nature;Neuronal Injury;neuroprotection;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Property;Protein C;Proteins;Proteomics;receptor;receptor expression;recombinant FVIIa;Recombinants;Regulation;Relative Risks;Research;Risk;Saphenous Vein;Stains;Stroke;Supportive care;Surface;surface coating;TBI treatment;Testing;Therapeutic;thrombogenesis;Thromboplastin;thrombotic;thrombotic complications;Time;tool;trafficking;Training;Translating;translational impact;Transmission Electron Microscopy;Traumatic Brain Injury;Treatment Efficacy;Variant;Vascular Permeabilities;Venous;Veterans;Work;wound

PROJECT_TITLE: Understanding and Enhancing the Therapeutic Efficacy of Factor VIIa for Emergency Hemostasis


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Biological processes, both normal and diseased, result from molecular interactions. Understanding these processes requires the ability to study biology over orders of magnitude of time and distance. The Cell, Molecular, Developmental Biology, and Biophysics (CMDB) Program provides interdisciplinary training to pre-doctoral researchers, allowing them to solve biomedical problems by bridging these different scales and connecting the behavior of organs and organisms to the motions and actions of molecules.

PI_NAMEs: KIM, JOHN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Cellular biology;Molecular Biology

PROJECT_TITLE: Cellular and Molecular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: HUTTENLOCHER, ANNA  (contact)

PROJECT_TERMS: Accreditation;Adult;anti-cancer research;Appointment;Award;Awareness;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Research Project;care providers;career;Career Mobility;Caring;Clinic;Clinical;Clinical Research;Collaborations;Communication;Communities;Critiques;Data;Decision Making;Development;diversity and inclusion;early-career faculty;Education;Empathy;empowerment;equity, diversity, and inclusion;experience;Faculty;Feedback;Fellowship;Fostering;Funding;Future;Goals;Grant;health equity;high school;improved;Individual;Infrastructure;Institution;Instruction;Internships;Investments;K-12 student;Laboratories;Leadership;Malignant Neoplasms;member;Mentors;Mentorship;mid-career faculty;Mission;Monitor;NCI Center for Cancer Research;Oncologist;Oncology;Outcome;outreach;Patients;peer;Peer Review;Phase;Postdoctoral Fellow;Prevention;Process;programs;Provider;Public Health;Recommendation;Research;Research Personnel;Research Training;Role;Running;Series;Societies;Students;success;Teacher Professional Development;tool;Training;Training and Education;training opportunity;training project;Travel;Trust;tumorigenesis;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;University of Wisconsin Comprehensive Cancer Center;Wisconsin;women faculty;working group;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: BIDAR-SIELAFF, SHIVA  (contact)

PROJECT_TERMS: Accountability;Advocacy;Age;Belief;Biological;Cancer Center;cancer prevention;career development;Career Mobility;Caring;Characteristics;clinical care;Clinical Research;Clinical Services;Communities;community center;Comprehensive Cancer Center;Creativeness;Diagnosis;Diverse Workforce;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;evidence base;Faculty;family structure;Fostering;Gender;gender expression;Gender Identity;Goals;Health;Health Sciences;Health system;Household;Immigration;improved;Individual;innovation;Institution;Instruction;Investments;Leadership;leadership development;Literature;Malignant Neoplasms;member;Mentors;Military Personnel;Mission;Monitor;National origin;Nationalities;Oncology;outreach;Patients;Policies;population health;Prevention;Productivity;professional atmosphere;Program Development;programs;Race;recruit;Religion;Research;Resources;Role;Scholarship;Sex Orientation;Socioeconomic Status;Strategic Planning;Surveys;System;Talents;Training;Translations;United States National Institutes of Health;Universities;Veterans;Vision;Voice;Wisconsin

PROJECT_TITLE: Plan to Enhance Diversity


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE mTORC1 signaling is abnormally activated in a variety of diseases. This proposal will establish a new level of understanding of how mTORC1 directly regulates the activity of metabolic pathways essential for cellular homeostasis. With the described aims, we will established a novel link between growth and pathological signals and the control of RNA methylation processes. Our preliminary data position us in the unique place to uncover and understand at a biochemical and molecular level new regulatory processes and new potential targets for drug discovery that are needed for therapeutic intervention in diseases driven by deregulated mTORC1 signaling.

PI_NAMEs: BEN-SAHRA, ISSAM  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: A549;Address;Aging;Anabolism;Apoptosis;Binding;Biochemical;Biological;Biology;Biomass;c-myc Genes;Cell Cycle Arrest;cell growth;Cell Survival;Cells;Chemicals;Clinic;Clinical;Complex;Consumption;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;dietary;Disease;DNA Methylation;DNMT3a;drug discovery;Drug Targeting;Environment;Enzymes;Epigenetic Process;Essential Amino Acids;Exhibits;FRAP1 gene;Genetic;Genetic Transcription;Glucose;Glutamine;Goals;Growth;Growth Factor;Hela Cells;histone methylation;Homeostasis;Human;Human Cell Line;Immunosuppression;inhibitor;insight;Introns;Isotope Labeling;Link;Lipids;macromolecule;Malignant Neoplasms;Mammalian Cell;Measures;MEL Gene;Messenger RNA;Metabolic;Metabolic Pathway;metabolic rate;Metabolic syndrome;Metabolism;metabolomics;Methionine;methionine adenosyltransferase;Methionine Metabolism Pathway;Methylation;Methyltransferase;Modification;Molecular;Motility;mouse model;Mutate;neoplastic cell;Nervous System Disorder;Neurodegenerative Disorders;novel;nucleotide metabolism;Nutrient;Obesity;Organ;Pathologic;Pathway interactions;Patients;PC3 cell line;Phosphorylation Site;Phosphotransferases;Physiological;Positioning Attribute;pre-clinical;Process;Proliferating;Protein Biosynthesis;Proteins;Proteomics;Reaction;Recycling;Regulation;Reporting;Ribosomal RNA;RNA;RNA Interference;RNA methylation;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;side effect;Signal Pathway;Signal Transduction;stable isotope;Syndrome;System;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Tracer;Transcriptional Regulation;tumor;tumor growth

PROJECT_TITLE: Control of RNA methylation by growth signals through the mTORC1 pathway

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE This proposal will expand upon a developed industrial partnership platform (Affibody AB, LI-COR Bio- sciences, Inc. and Dartmouth Engineering & Oncology) for the bench-to-clinical translation of an EGF- receptor targeted fluorescent peptide via the FDA exploratory investigational new drug pathway. The utility of this pipeline will be demonstrated by testing efficacy of tumor detection in Phase II trials for both primary high-grade glioma and head and neck cancers, and translating a paired-imaging agent drug product, which improves the efficiency and the efficacy of fluorescence guided surgery. In addition, DoseOptics will join the industrial partnership to develop much needed imaging instrumentation with high sensitivity to near-microdose levels of fluorescent agents in full surgical lights.

PI_NAMEs: PAULSEN, KEITH D. (contact);SAMKOE, KIMBERLEY

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acceleration;Adverse effects;Aminolevulinic Acid;Animal Model;bench to bedside;Biological Sciences;carboxylate;Clinical;clinical development;Clinical Research;clinical translation;cost;cost effective;Custom;Data;design;Detection;detection sensitivity;Development;Diagnostic;Disease;Dose;drug development;efficacy study;efficacy testing;EGFR Protein Overexpression;Engineering;Epidermal Growth Factor Receptor;Excision;experience;first-in-human;Fluorescence;fluorescence-guided surgery;Fluorescent Dyes;fluorophore;Funding;Glioma;Goals;Good Manufacturing Process;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Image;imaging agent;imaging capabilities;imaging system;Imaging technology;improved;In Situ;in vivo;Industrialization;industry partner;Infiltration;Infrastructure;instrumentation;Intellectual Property;Investigational Drugs;Investigational New Drug Application;Left;Limb structure;Malignant Neoplasms;medical schools;Methodology;Microscope;minimally invasive;Molecular;Molecular Target;Names;neurosurgery;New Drug Approvals;No-Observed-Adverse-Effect Level;novel;Oncology;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;Performance;Pharmaceutical Preparations;Phase;Phase 0 Clinical Trial;Phase 0 Trial;phase 2 designs;phase 2 study;phase 2 testing;phase 3 study;Phase II Clinical Trials;phase II trial;pre-clinical;preclinical toxicity;primary endpoint;Probability;Procedures;Productivity;Protocols documentation;Randomized;research clinical testing;Research Personnel;Resectable;Residual state;Risk;Safety;Secondary to;Sensitivity and Specificity;Signal Transduction;Soft tissue sarcoma;Solid Neoplasm;standard of care;Structure;success;surgery outcome;Surgical margins;Surgical Oncology;synthetic peptide;System;Testing;timeline;Tissue imaging;Tissues;Toxic effect;Toxicity Tests;Tracer;Translating;Translations;tumor;Tumor Tissue;Work

PROJECT_TITLE: Advancing molecular fluorescence-guided surgery platform


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: AHMAD, NIHAL  (contact)

PROJECT_TERMS: Address;Affect;African American;Area;Award;Basic Science;Behavioral;Bioinformatics;Biological Markers;biopsychosocial factor;Black race;Breast Cancer Detection;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;Cancer Patient;cancer prevention;cancer risk;cancer site;cancer therapy;care delivery;Catchment Area;Chemoprevention;Chemopreventive Agent;clinical care;Clinical Sciences;clinically significant;Cognitive;Collaborations;college;Colorectal Cancer;colorectal cancer screening;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;coping;Databases;Development;Diagnosis;Diagnostic;Diagnostic tests;Direct Costs;Disease;drug development;Early Diagnosis;early phase clinical trial;Early treatment;Education;end of life;evidence base;experience;Family;Fostering;Funding;Goals;Grant;Guidelines;health equity;Health Policy;Health Services Research;Human Papilloma Virus Vaccination;Improve Access;improved;Incidence;individualized prevention;innovation;insight;Instruction;inter-institutional;Interdisciplinary Study;Intervention;Intervention Studies;Lead;lifestyle intervention;Low income;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;member;Mental Health;Mentors;Mission;models and simulation;multidisciplinary;novel;novel strategies;Observational Study;Outcome;Palliative Care;Patients;Peer Review;Performance;Persons;pharmacologic;Physical activity;Population;population health;Population Sciences;Prevention;Prevention Research;Primary Care;programs;Provider;Psychosocial Assessment and Care;Published Comment;Publishing;Recommendation;Research;research clinical testing;Risk Reduction;Role;Rural;Scholarship;Schools;Science;Scientist;Screening for cancer;Smoking;Strategic Planning;Supportive care;survivorship;Symptoms;synergism;System;Testing;Tobacco;tobacco cessation intervention;tobacco exposure;Tobacco use;Tobacco Use Cessation;Universities;Update;Vaccines;Wisconsin;working group

PROJECT_TITLE: Cancer Prevention and Control


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Sleep Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project narrative Sleep disturbance in persons living with dementia and their caregivers is a significant public health burden which is associated with depressive symptoms and poorer quality of life. We will use design thinking, human- centered approaches to tailor a dyadic behavioral intervention for sleep disturbance for persons living with mild cognitive impairment or early-stage Alzheimer’s disease and related dementias and their caregivers; then, we will conduct a waitlist randomized controlled trial (N = 40 dyads) to examine the intervention’s acceptability, feasibility, and preliminary efficacy on individual and dyadic objective and subjective sleep outcomes. The findings of the proposed project will inform future larger-scale clinical trials and can provide a novel and innovative method for persons living with mild cognitive impairment or early-stage dementia and their caregivers to achieve better sleep and quality of life outcomes.

PI_NAMEs: BREWSTER, GLENNA SHEMIDA (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adherence;Adult;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;analytical method;Beds;Behavior Therapy;Behavioral;behavioral and social science;behavioral sleep intervention;Caregiver research;Caregivers;caregiving;Clinical Trials;Cognitive;cognitive skill;Cognitive Therapy;Collaborations;Community Healthcare;comparison control;Control Groups;Dementia;dementia care;Dementia caregivers;dementia caregiving;depressive symptoms;design;Development;Diagnosis;diaries;Disease;effective intervention;Effectiveness;Evidence based intervention;experience;falls;Foundations;Future;Goals;group intervention;Habits;Health;Health Personnel;Human;improved;improvement on sleep;indexing;Individual;innovation;Intervention;Intervention Studies;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Learning;Literature;Manuscripts;member;memory care;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;National Institute on Aging;Neurology;Neurosciences;novel;Oral;Outcome;patient oriented;Peer Review;Personhood;Persons;Phase;pilot test;Polysomnography;poor health outcome;poor sleep;Population;Prevalence;primary outcome;Process;programs;prototype;psychologic;Psychology;Public Health;Quality of life;Questionnaires;Randomized, Controlled Trials;Reporting;Research;Research Project Grants;Residential Treatment;rumination;satisfaction;Schedule;Severities;skills;Sleep;sleep behavior;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;Stimulus;Structure;Testing;theories;therapy development;Thinking;Time;Training;United States National Institutes of Health;university student;Veterans;virtual;Visualization;Waiting Lists;Work;Writing

PROJECT_TITLE: Using design thinking approaches to tailor a dyadic behavioral sleep intervention for persons living with dementia and their caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Memory is a active process that allows for the recall of previous experiences to guide future behavior. This proposal seeks to understand the reorganization and function of cortical networks that mediate remote but not recent memory. Results from these experiments will reveal fundamental processes by which the brain stores, transforms, and recalls memories over time, while also illuminating the function of a novel class of prefrontal neurons that may inform treatment of fear disorders

PI_NAMEs: ZEIDLER, ZACHARY E (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Age;Anatomy;Anxiety Disorders;Area;association cortex;Auditory;Axon;Behavior;Behavior Control;Behavioral;Brain;Brain Mapping;Calcium;career;cell type;Cells;conditioned fear;Coupling;Cues;Data;design;Disease;effective intervention;emotional experience;Event;experience;experimental study;fear memory;Foundations;Freezing;Fright;Functional disorder;Future;Gene Expression;genetic approach;Goals;Head;Image;Immediate-Early Genes;improved;insight;Label;Light;Link;long term memory;Maps;Medial;Mediating;Memory;memory recall;memory retrieval;Mentors;Methods;Microscope;Modeling;National Institute of Mental Health;Nature;neural;neural circuit;Neurons;novel;optogenetics;Output;Pattern;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Process;Publishing;recruit;Research;Resistance;Retrieval;Role;symposium;Testing;therapeutic target;Time;timeline;Tissues;Trauma;Viral Physiology;virus genetics;Work

PROJECT_TITLE: Reorganization of cortical memory ensembles across time


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This proposed study will examine the degree to which experiences of interpersonal and structural discrimination in Latina mothers may induce inflammation in both mother and child via immune dysregulation — a fundamental pathway linking psychosocial stress to disease. Chronic inflammatory health conditions may be preventable by identifying and subsequently targeting maternal stressors through equitable evidence-based interventions. Understanding early-life social and biological interactions offers an opportunity to address social inequities and alter health trajectories before they evolve into costly health disparities.

PI_NAMEs: HARRIS, REBECA ALVARADO (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: 5 year old;Acculturation;Address;Adult;analytical method;Award;Biological;Birth;career development;Child;Child health equity;Childhood;childhood adversity;Chronic;Chronic Disease;cohort;Cohort Studies;Communities;community engaged approach;Critical Pathways;Data;Data Collection;Depressed mood;depressive symptoms;Development;Development Plans;Disadvantaged;Discrimination;Disease;DNA Methylation;early childhood;Emotional;emotional functioning;Equity;Evidence based intervention;experience;Family;Fellowship;Fetal Development;Foundations;Growth;Health;Health Care Costs;health determinants;health disparity;Human Development;Immigrant;Immune;Immune system;Immunologic Markers;immunoregulation;Impairment;in utero;Inequity;Inflammation;Inflammatory;intergenerational;Interleukin-6;Knowledge;knowledge integration;Latina;Latina Population;Latinx;Latinx population;Life;life span;Link;Literature;Low Birth Weight Infant;low socioeconomic status;Maternal and Child Health;maternal stress;Measures;Mediating;Mental Depression;Mentorship;migration;Modeling;Mothers;Neighborhoods;NR3C1 gene;Nurses;Obesity;Outcome;Pathway interactions;perceived discrimination;perinatal period;Personal Satisfaction;Plasma Proteins;Population Group;pre-clinical;Pregnancy;pregnant;preventive intervention;Psychosocial Stress;Regulator Genes;Reporting;Research;research and development;Research Personnel;Research Priority;Risk;Role;Safety;Scientist;segregation;skills;social;Social Environment;social health determinants;Social support;Strategic Planning;Stress;stressor;Subgroup;theories;Time;TNF gene;Training;Woman

PROJECT_TITLE: The Role of Structural and Interpersonal Discrimination on Latina Mother and Child Immune Pathways

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Immuno-Oncology has made significant progress over the past 5-6 years with the development of checkpoint blockade immunotherapy which has changed treatment approaches given manageable side effects and improved efficacy. However, the benefits are still limited to a subset of Veterans, and it is critical to understand how cancer cells are becoming resistant to immune attack in order to expand the benefits to many Veterans with advanced cancer. The current research proposal is designed to understand the mechanism of resistance, or immune evasion, by focusing on the role of a particular protein that modulates the structure of chromatin in the genome, the so-called ‘chromatin remodeler’. We observed that the tumor grew faster with immunotherapy if it is lacking ATRX, a chromatin remodeler and this phenotype mirrors the unwanted clinical outcome, called ‘hyperprogression’. Hence, I strongly believe the current proposal will provide understanding of how cancer cells grow faster with immunotherapy that, in turn, will lead us to develop the strategies to overcome it.

PI_NAMEs: SHIN, DANIEL SANGHOON (contact)

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;anti-PD1 antibodies;anti-PD1 therapy;antitumor effect;ATAC-seq;Atlases;ATRX gene;Binding;Biological Assay;C57BL/6 Mouse;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;cBioPortal;Cell Line;Cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Clinical;Coculture Techniques;Colorectal Cancer;Complex;Coupled;CRISPR/Cas technology;Data;demethylation;design;Development;Diagnosis;Elements;Embryo;Epigenetic Process;Exhibits;experimental study;EZH2 gene;Feedback;Fibroblasts;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;Genomics;Granzyme;Health;Histone Deacetylase Inhibitor;Human;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunocompetent;Immunooncology;Immunotherapy;improved;in vivo;inhibitor;Interferon Receptor;Interferon Type II;Interferons;IRF1 gene;JAK1 gene;JAK2 gene;Janus kinase;Kidney;Knock-out;Lentivirus Vector;loss of function;loss of function mutation;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;MC38;Mediating;Melanoma;Melanoma Cell;Military Personnel;Modeling;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;Outcome;Parents;Pathway interactions;patient subsets;Patients;PD-1 blockade;perforin;Phenotype;Play;polybromo;Polycomb;Process;programmed cell death ligand 1;promoter;Proteins;receptor;Reporting;Research;Research Design;Research Proposals;Resistance;resistance mechanism;response;Rest;RNA Sequences;Role;screening;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;Sleeping Beauty;Small Interfering RNA;Specificity;System;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;tool;Transcript;transcriptome;transcriptome sequencing;Transposase;Treatment Efficacy;treatment response;trend;tumor;tumor growth;Untranslated RNA;vector;Veterans;XCL1 gene

PROJECT_TITLE: Role of ATRX, a chromatin remodeler, in immunotherapy response


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Somatosensory disorders, such as chronic itch and chronic pain, are major public health problems and produce a significant economic and social burden. The proposed work aims to investigate novel functions of the lateral habenular (LHb) and the trigeminal cutaneous mechanosensory sensory afferents in transmitting the scratching information to suppress scratching. Our anticipated results will provide critical insight into the unexplored neural mechanisms of how scratching negatively modulates itch, which could provide novel targets for alleviating chronic pain.

PI_NAMEs: LUO, WENQIN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Acute;adeno-associated viral vector;Affect;Anxiety;Area;Behavior;behavioral response;Bilateral;Brain;Brain region;C Fiber;Calcium Signaling;Caspase;Cells;Cheek structure;Chemicals;chronic itch;chronic pain;comorbidity;Contralateral;Cre driver;Cutaneous;designer receptors exclusively activated by designer drugs;Economics;effective intervention;Electrophysiology (science);Epithalamic structure;Esthesia;Fiber;FOS gene;Genetic;genetic approach;Genetic Recombination;Genetic Transcription;Habenula;Hair;Immunohistochemistry;In Situ Hybridization;in vivo;Individual;Injections;insight;Ipsilateral;Lateral;mad itch virus;mechanical force;Mechanics;Mechanoreceptors;Mediating;Mental Depression;Modeling;Molecular;molecular marker;motivated behavior;Motor;Mus;Neck;Negative Valence;neural circuit;Neural Pathways;neuromechanism;Neurons;novel;optogenetics;Outcome;Pain;pain sensation;patch clamp;pharmacologic;Phenotype;Photometry;Physiological;Play;Population;Positioning Attribute;prevent;Process;Property;Pruritus;Public Health;Quality of life;recruit;response;Role;Sensory;sensory input;Side;Skin;skin lesion;Sleep Deprivation;Slice;social;Somatosensory Disorders;Stimulus;Synapses;Techniques;Testing;transmission process;Trigeminal System;Virus;Work

PROJECT_TITLE: Determine Functions of the Lateral Habenular and Trigeminal High Threshold Mechanoreceptors in Mediating Scratching-induced Responses

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Psychosis

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: PROJECT NARRATIVE Neuropsychiatric manifestations are common in Rare Genetic Disorders (RGDs), affecting brain development and functioning throughout the lifespan; copy number variants (CNVs) at 22q11.2 and 16p11.2 loci are among the most common RGDs impacting developmental psychopathology. We propose to capitalize on highly informative samples and integrate prospective dimensional and categorical phenotyping with whole genome sequencing across these reciprocal CNVs. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.

PI_NAMEs: VORSTMAN, JACOB A.S. (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 16p11.2;22q11.2;adverse outcome;Affect;Algorithms;Anxiety;Anxiety Disorders;Architecture;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;Behavior;Brain;case control;Clinical;clinical diagnosis;clinical phenotype;clinical predictors;Cognition;Cognitive;cohort;Collaborations;Complement;Complex;Computing Methodologies;Copy Number Polymorphism;Data;Development;Developmental Course;Developmental Delay Disorders;Diagnosis;Dimensions;Disease;Early Intervention;Emotional;Emotions;Environment;Environmental Risk Factor;Evaluation;experience;externalizing behavior;Family;Family member;gene environment interaction;Genetic;genetic architecture;Genetic Determinism;genetic pedigree;Genetic Predisposition to Disease;Genetic study;genetic variant;genome resource;genome sequencing;genome wide association study;genomic locus;Genomics;Goals;Heterogeneity;Hyperactivity;Individual;Institution;Intellectual functioning disability;interest;International;Knowledge;large scale data;life span;Literature;Measures;Memory;Mental Depression;model building;Modeling;Molecular;National Institute of Mental Health;Nature;neurobehavioral;neurobiological mechanism;Neurocognition;neuropsychiatric disorder;neuropsychiatry;Online Systems;Outcome;Patients;personalized approach;phenomics;Phenotype;polygenic risk score;Population;Positioning Attribute;processing speed;prospective;Psychiatric Diagnosis;Psychopathology;Psychoses;Public Domains;rare genetic disorder;rare variant;recruit;Recurrence;Risk;risk prediction model;Sampling;Schizophrenia;social;Social Behavior;Specificity;symptomatology;Symptoms;Syndrome;theory of mind;tool;Variant;whole genome;Work

PROJECT_TITLE: 5/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders


PI_NAMEs: DEMING, DUSTIN A (contact)

PROJECT_TERMS: adaptive immunity;Address;Adult;Advanced Malignant Neoplasm;Antibodies;Antibody-drug conjugates;Applied Research;Award;Basic Science;bench to bedside;Biological Markers;biomarker development;biomarker driven;biomarker validation;Cancer Center;Cancer Patient;candidate identification;Catchment Area;Cell Therapy;Child;chimeric antigen receptor T cells;Chromosomal Instability;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;college;Combination immunotherapy;Communities;Comprehensive Cancer Center;Consultations;Dedications;Dendritic Cell Vaccine;Destinations;Development;Developmental Therapeutics Program;Direct Costs;Disease;drug development;drug discovery;early phase clinical trial;effective therapy;Flow Cytometry;Fostering;Funding;Goals;Grant;Head and Neck Cancer;Hematologic Neoplasms;Image;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunotherapeutic agent;Immunotherapy;improved;Instruction;inter-institutional;Journals;lead candidate;Leadership;Lymphoma;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;meetings;member;Mentorship;Mesenchymal Stem Cells;Mission;molecular drug target;Molecular Target;monocyte;Multiple Myeloma;Natural Immunity;Natural Killer Cells;novel;novel therapeutics;patient oriented;Patient-Focused Outcomes;Patients;Peer Review;Pharmaceutical Preparations;Phase;Phase II/III Trial;pre-clinical;pre-clinical research;precision medicine;programs;Prostate;Publications;Regulation;Research;Research Personnel;Resistance;response;Schools;Science;Solid Neoplasm;Source;Strategic Planning;success;targeted cancer therapy;targeted treatment;taxane;Therapeutic;Therapeutic Agents;therapeutic development;Therapy Clinical Trials;TP53 gene;Training Programs;Translating;Translational Research;Translations;treatment strategy;tumor;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Developmental Therapeutics


ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative Understanding the underlying molecular details of biological processes requires knowledge of the concepts, tools, and techniques of chemistry and biology. The UMass Chemistry-Biology Interface (CBI) Training Program seeks to train the next-generation of interdisciplinary scientists to solve frontier problems in biology by providing a collaborative community, innovative curriculum, and skills to reach their career goals.

PI_NAMEs: STRIETER, ERIC ROBERT (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Chemistry-Biology Interface Predoctoral Training Grant

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This proposal seeks to generate new knowledge regarding the pathogenesis and treatment of Chronic Obstructive Pulmonary Disease, the fourth leading cause of death in the US. Specifically, we propose to investigate how a mediator called FoxP1 helps maintain protein quality control in cells that line the airways of the lung after exposure to cigarette smoke, and determine if increasing FoxP1 protein levels in the lung is a viable treatment strategy for COPD in preclinical models. The new knowledge gained may lend itself to therapeutics that lessen the burden of COPD; therefore, this proposal is aligned with the objectives of the COPD National Action Plan.

PI_NAMEs: CHANDRA, DIVAY  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adenoviruses;Air;airway epithelium;airway obstruction;Apoptosis;Apoptosis Promoter;ATF6 gene;Award;Binding;Binding Sites;biobank;Biological Assay;Cause of Death;Cell Line;Cells;ChIP-seq;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;Cigarette smoke-induced emphysema;Cleavage Under Targets and Release Using Nuclease;cohort;computer studies;Data;Development;Disease;DNA Sequence;efficacy testing;EIF-2alpha;Epithelial Cells;Epithelium;exposure to cigarette smoke;forkhead protein;Genes;Genome;GRP78 gene;HepG2;Human;human embryonic stem cell;Immunofluorescence Immunologic;In Situ Nick-End Labeling;In Vitro;in vivo;Induction of Apoptosis;Intranasal Administration;Knowledge;Length;Link;LoxP-flanked allele;Luciferases;Lung;Maps;Mediating;Mediator;Messenger RNA;multicatalytic endopeptidase complex;Mus;Mutagenesis;mutant;novel;overexpression;Pathogenesis;PAWR protein;Phosphorylation;Pre-Clinical Model;preservation;prevent;Probability;promoter;Promoter Regions;Proteins;Pulmonary Emphysema;Quality Control;Reporter;Repression;response;Role;Stains;Testing;Therapeutic;transcription factor CHOP;Transcription Repressor;treatment strategy;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Role of FBXO24 mediated ubiquitination of FoxP1 protein in the pathogenesis and treatment of COPD

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Significant research efforts are currently underway to understand and prevent the pathogeneses of Type 1 and Type 2 diabetes, both of which are associated with the gradual loss of functional insulin-producing b cells. Progress has been made with using human pluripotent stem cell (hPSC) populations as alternative sources of islet cells; however, the efficient production of pure populations of fully functional b cells has not yet been achieved. This project will use mouse and hPSC models to identify the complex transcriptional and epigenetic mechanisms that promote the specification and maintenance of islet cell identities.

PI_NAMEs: SUSSEL, LORI  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adult;Advocate;Affect;ATAC-seq;B cell differentiation;B-Cell Development;B-Lymphocytes;Biological;Cell Differentiation process;Cell Line;Cell Lineage;Cell Physiology;cell type;Cells;CHD4 gene;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Code;cofactor;combinatorial;Complex;Development;Diabetes Mellitus;differentiation protocol;directed differentiation;Duct (organ) structure;Endocrine;Epigenetic Process;experimental study;Family member;Functional disorder;functional loss;Funding;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genetic corepressor;Genetic Transcription;Genomics;Goals;Human;human pluripotent stem cell;Hyperglycemia;Impairment;improved;in vivo;Insulin;islet;Islet Cell;Islets of Langerhans;Knowledge;Maintenance;member;Methods;Molecular;mouse development;Mus;mutant;novel;NuRD complex;Pancreas;pancreas development;Pathogenesis;Phenotype;Physiological;pluripotent stem cell differentiation;Population;prevent;Procedures;Production;programs;Proteins;Protocols documentation;Regulation;Reporting;Research;Research Personnel;response;Rodent Model;Role;single cell ATAC-seq;single nucleus RNA-sequencing;Source;Specific qualifier value;stem cell model;stem cell population;stem cells;synergism;System;Techniques;Technology;transcription factor;transcriptome;transcriptome sequencing;Translating;type I and type II diabetes

PROJECT_TITLE: Regulation of pancreatic islet cell fate

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

PI_NAMEs: BRESNICK, EMERY H (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Arginine;bench to bedside;biomarker performance;Budgets;Cancer Biology;cancer cell;cancer diagnosis;cancer genetics;Cancer Patient;cancer predisposition;cancer prevention;cancer risk;cancer type;Catchment Area;Cells;chromatin remodeling;Chromatin Remodeling Factor;Clinical;clinical diagnostics;clinical practice;Clinical Trials;Collaborations;Comprehensive Cancer Center;computerized tools;data infrastructure;Data Scientist;data sharing;Diagnosis;Diagnostic;Diet and Nutrition;Early Diagnosis;Enrollment;Ensure;Enzymes;Epigenetic Process;epigenetic therapy;epigenome;Evaluation;faculty mentor;Faculty Recruitment;forging;Fostering;Funding;Gene Expression;Genetic;Genetic Medicine;Genetic Screening;genetic variant;Genome;genome sequencing;Grant;Growth;Hematological Disease;Hematopoietic Neoplasms;Human;Immunotherapy;improved;Informatics;informatics shared resource;Inherited;innovation;innovative technologies;Instruction;inter-institutional;interdisciplinary collaboration;invention;Knowledge;Lead;Leadership;Licensing;Link;Malignant Breast Neoplasm;Malignant Neoplasms;meetings;member;Methionine;Methylation;Mission;model organism;Molecular Medicine;multidisciplinary;multiple omics;Neoplasm Metastasis;nutrition;Oncogenic;oncohistone;Oncology;Patients;Pilot Projects;precision medicine;precision medicine clinical trials;Precision Medicine Initiative;precision oncology;Prediction of Response to Therapy;predictive marker;Prevention;Productivity;professor;programs;prospective;Protein Isoforms;Proteins;Publications;recruit;Research;Strategic Planning;Structure;System;technological innovation;Technology;Text;Therapeutic;therapeutic target;tool;Translating;translational approach;translational goal;translational potential;Translational Research;translational scientist;Translations;treatment response;tumor;tumor DNA;tumorigenesis;Variant

PROJECT_TITLE: Cancer Genetic and Epigenetic Mechanisms


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative This predoctoral training program implements a team approach to scientific research with an emphasis on entrepreneurial training and professional development. The program will train the next generation of graduate students to flourish in teams and embrace an entrepreneurial perspective that enhances innovation and impact. The theme of entrepreneurship in theranostics (therapeutics and diagnostics) is motivated by the significant opportunities for technology development and aligns with the established strengths of our graduate programs in chemistry, molecular biology, and chemical engineering.

PI_NAMEs: BRODBELT, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: Problem-to-Product Team Entrepreneurship and Active Mentoring (P2P-TEAM) Graduate Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Disappointing results from clinical trials designed to delay cognitive decline and treat AD/ADRD in older adults are precipitating a shift from testing promising interventions in late life towards midlife, before irreversible damage has accumulated. This shift, however, requires targeting midlife biomarkers that can predict clinical changes manifesting only in late life. The research proposed in this renewal application seeks to quantify individual differences in MRI measures of at-risk changes in midlife structural brain integrity that are known to be associated with AD/ADRD later in life, and to examine the extent to which these individual differences are predicted by AD/ADRD risk indexes and map onto variability in trajectories of cognitive decline, the pace of biological aging, and blood AD/ADRD biomarkers.

PI_NAMEs: HARIRI, AHMAD R. (contact);MOFFITT, TERRIE E

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Age;age effect;age related chronic disease;Aging;aging process;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Area;Award;Biological Aging;Biological Assay;Biological Markers;Biology;Birth;Blood;Blood specimen;Body System;Brain;Cementation;Childhood;Cities;Clinical;clinical predictors;Clinical Trials;Clinical Trials Design;Cognition;cognitive function;cohort;Cohort Effect;Crystallization;Data;Data Collection;dementia risk;density;design;Detection;Diagnosis;Disease;Episodic memory;executive function;experience;follow-up;Functional disorder;Genetic Predisposition to Disease;Geroscience;Hemorrhage;hippocampal atrophy;Image;Impaired cognition;Incidence;indexing;Individual;Individual Differences;Infant;Intervention;Intervention Studies;Intervention Trial;late life;Life;life span;lifestyle factors;Liquid substance;longitudinal design;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurable;Measurement;Measures;member;Methodology;middle age;Modeling;Neurites;novel;older adult;Outcome;Outcome Measure;Participant;Pathology;Pattern;Population;pre-clinical;Prevention Research;Prevention trial;processing speed;Proteins;rate of aging;Research;Research Design;Resources;Risk;Sampling;Short-Term Memory;sound;Specific qualifier value;Structure;Surface;Surrogate Markers;Testing;theories;therapy design;Thinness;timeline;White Matter Hyperintensity

PROJECT_TITLE: Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD Risk

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer’s disease or a related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated with the disease process. In the context of ADRD, medical decision-making at the end-of-life is typically left to one’s care partner, who often does not have the knowledge or confidence in their ability to make such decisions. This study will refine and evaluate a web-based platform, called the LEAD Intervention (Life-Planning in Early Alzheimer’s and Dementia), which is designed to help persons in the preclinical or early stage of ADRD engage in conversations about, document, and share their end-of-life values and preferences with a care partner, extended family members, and health care providers.

PI_NAMEs: DASSEL, KARA BOTTIGGI (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Adult Children;Advance Care Planning;advanced directive;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;Awareness;Behavior Therapy;care preference;care recipients;Caring;Child;Cognitive;cognitive function;Communication;Communities;community advisory board;Community Healthcare;Consultations;Decision Making;Dementia;dementia care;dementia risk;design;Deterioration;Discourse analysis;Disease;Documentation;Educational Materials;end of life;Event;Extended Family;Family;Family health status;Family member;family support;Funding;Future;Geographic Locations;Goals;health care availability;health care settings;Health Personnel;Healthcare;hospital readmission;Impaired cognition;improved;Individual;Intervention;Knowledge;Lead;Learning Module;Left;Life;Long-Term Care;longitudinal analysis;Medical;Methods;Online Systems;Outcome Assessment;Outcome Measure;Parents;Participant;Personal Satisfaction;Persons;Population;population based;pre-clinical;preference;primary outcome;Process;process evaluation;Public Health;Quality of life;Recommendation;Research Methodology;research study;Resources;Safety;Sampling;secondary outcome;Self Administration;Self Efficacy;Spouses;surrogate decision maker;Surveys;Time;tool;United States National Institutes of Health;usability;Value of Life;Video Recording;web app;web platform;web-based intervention;web-based tool

PROJECT_TITLE: LEADing End-of-Life Dementia Care Conversations

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE Per PAR-21-321 instructions, this component is not required.

PI_NAMEs: KIMPLE, RANDALL J. (contact)

PROJECT_TERMS: Achievement;artificial intelligence method;Attention;Award;Biological Sciences;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Survivor;cancer therapy;Catchment Area;Cell Therapy;clinical practice;Clinical Research;clinical translation;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computed Tomographic Colonography;Dedications;delivery vehicle;Development;Direct Costs;elastography;Electrodes;electron energy;Environment;first-in-human;Funding;Genomics;Goals;Grant;Growth;Head and Neck Cancer;Health;Human;human study;Image;image guided;imaging agent;imaging modality;Imaging technology;Immunotherapy;improved;Individual;innovation;Instruction;Journals;Leadership;leukemia;Local Therapy;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;Methodology;microwave ablation;Mission;Molecular;molecular imaging;Molecular Target;Multiple Myeloma;nanomaterials;novel;novel strategies;Oligonucleotides;Oncology;Patients;Peer Review;physical science;Physics;Play;Positron;Production;Productivity;programs;Publications;quantitative imaging;Radiation;radiation delivery;Radiation Oncology;Radiation therapy;Radiobiology;Radioisotopes;Radiolabeled;Radiology Specialty;Radionuclide therapy;Radiopharmaceuticals;Reproduction spores;Research;Research Personnel;Resistance;resistance mechanism;Resources;Role;Science;side effect;success;Systemic Therapy;targeted treatment;Techniques;theranostics;Therapeutic;Therapeutic Intervention;therapy resistant;Time;Toxic effect;Translating;Translational Research;Translations;treatment planning;treatment response;Treatment-related toxicity;tumor ablation;ultrasound;Xerostomia

PROJECT_TITLE: Imaging and Radiation Sciences


ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Salmonella are among the increasing number of medically important multidrug resistant bacteria. Salmonella and antibiotic-resistant Salmonella cause high morbidity and mortality in veterans, patients in VA hospitals and the general population. A better understanding of the molecular mechanisms of Salmonella pathogenesis will inform the rational development of novel therapies and prophylactic countermeasures. Our investigations have revealed that the conserved RNA polymerase-binding DksA and Gre proteins are essential to Salmonella pathogenesis. The proposed research will determine the molecular mechanisms by which 1) the binding of DksA and Gre factors to the secondary channel of RNA polymerase controls to the antioxidant defenses that facilitate Salmonella virulence in vertebrate hosts, and 2) Gre-guided backtracking of RNA polymerase contributes to the resistance of Salmonella to antibiotics. Knowledge of DksA- and Gre factor-mediated regulation of transcription will help identify new targets for the development of future antimicrobials.

PI_NAMEs: VAZQUEZ-TORRES, ANDRES  (contact)

PROJECT_TERMS: Aminoglycoside Antibiotics;Aminoglycoside resistance;Aminoglycosides;Antibiotic Resistance;antibiotic tolerance;Antibiotics;antimicrobial;Antimicrobial Resistance;Antioxidants;attenuation;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bactericide;Binding;Blood;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinic;Clinical;clinically relevant;Data;Development;Diarrhea;DNA-Directed RNA Polymerase;drug resistant bacteria;Family;fighting;Future;Gastroenteritis;Gene Cluster;General Population;Genetic Transcription;global health;Goals;HIV;Hospitals;Human;human pathogen;Individual;Inflammation Mediators;Investigation;Knowledge;Laboratories;Life;Life Style;Mediating;Medical;men;Military Personnel;Molecular;Molecular Analysis;Molecular Chaperones;Molecular Target;Morbidity - disease rate;mortality;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Mus;mutant;NADPH Oxidase;non-typhoidal Salmonella;novel;novel therapeutics;nucleoside triphosphate;Oxidative Stress;Oxidoreductase;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity Island;Patients;Persons;Plague;Play;Poison;programs;prophylactic;Proteins;Regulation;Research;Resistance;response;RNA;RNA Proof-Reading;Role;Salmonella;Salmonella enterica;Secondary to;Syndrome;Testing;Therapeutic;Transcription Elongation;Transcriptional Activation;Transcriptional Regulation;Translations;Type III Secretion System Pathway;Veterans;Virulence;Woman;Work;World Health Organization

PROJECT_TITLE: Molecular Analysis of Bacterial Adaptive Response to Host Reactive Species


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Our research focusing on new therapeutics for Neisseria gonorrhoeae infection is highly relevant to the U.S. military and Veterans. Cases of gonorrhea are a major cause of morbidity with an estimated 850,000 cases in the U.S. and 87 million cases worldwide. Within the VA Health Care System, the incidence of gonorrhea increased between 2013 and 2017 with the total number of cases at 10,587. There is no vaccine to N. gonorrhoeae and a great need for new antibiotics due to the alarming rise in multidrug resistant strains, which is making emergence of untreatable gonococcal infections a real prospect. The high-risk environment of active military service is thought to increase risky behavior and, thus, the rate of sexually transmitted infections. Military and Veteran females, who incur a rate of gonorrhea that is higher than for civilian females and who suffer more frequent and serious complications than men, represent 15% of active duty military personnel and 2 million Veterans. Thus, our proposed research is relevant to the health and patient care missions of the VA.

PI_NAMEs: JARVIS, GARY A (contact)

PROJECT_TERMS: active duty;Amino Acids;Anabolism;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Cationic Peptides;Azithromycin;Bacteria;bactericide;Binding Proteins;Biological Assay;Canada;Cardiovascular system;Cefixime;Ceftriaxone;Cells;Cephalosporins;Cervical;chronic pelvic pain;Classification;Clinical;Complement;Country;cytokine;Cytolysis;cytotoxicity;Data;Denmark;design;DNA Binding;Drug Kinetics;Drug-resistant Neisseria Gonorrhoeae;Ectopic Pregnancy;efficacy testing;efflux pump;Environment;Enzymes;Epithelial Cells;Evaluation;Exposure to;Female;Generations;Gonorrhea;Gram-Negative Bacteria;Healthcare;Healthcare Systems;Hemolysis;high risk;HIV;Human;Immune response;In Vitro;in vitro Assay;in vitro testing;in vivo;in vivo evaluation;Incidence;Infection;Infertility;Inflammation;Inflammatory;inhibitor;Innate Immune System;interest;Invaded;Investigation;Japan;lead candidate;Lipid A;lipid biosynthesis;lipooligosaccharide;Measurable;Mediating;Membrane;men;Military Personnel;military service;Mission;Modeling;Morbidity - disease rate;mouse model;Multi-Drug Resistance;Neisseria gonorrhoeae;neutrophil;novel;novel therapeutics;Outcome;Patient Care;Pelvic Inflammatory Disease;Penetration;Peptides;Permeability;Predisposition;prevent;Proteolysis;Public Health;Recommendation;Reporting;reproductive tract;Research;Resistance;Resistance development;resistant strain;Risk Behaviors;Sexually Transmitted Diseases;Testing;Therapeutic;Time;Toxic effect;transmission process;Vaccines;Variant;Veterans;Woman;Work

PROJECT_TITLE: Targeting of LOS for Treatment of Antibiotic-Resistant Neisseria gonorrhoeae


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Acinetobacter baummannii is a leading bacterial pathogen in both VA and civilian hospitals and is a common cause of infections in injured military personnel. The frequency of A. baumannii infections is increasing and the problem of antibiotic resistance has reached a critical stage. In fact, pan-resistant strains that are untreatable by all available antibiotics have become a reality with A. baumannii. This has prompted the World Health Organization to place A. baumannii at the top of their list of critical pathogens where new antibiotics are needed. This study will exploit a virulence switch in A. baumannii to develop novel translational interventions, including a live attenuated vaccine strain and the identification of small molecules that drive cells into an avirulent state.

PI_NAMEs: RATHER, PHILIP N. (contact)

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Animal Model;Antibiotic Resistance;Antibiotics;Attenuated;Attenuated Vaccines;attenuation;Automobile Driving;Back;capsule;cell type;Cells;combat;comparative;Complex;Development;Disease;emerging pathogen;Exhibits;experimental study;Family;Frequencies;Funding;Gene Expression;Genes;high throughput screening;Hospitals;Human;immunogenic;in vivo;Individual;Infection;inhibitor;Intervention;Lighting;Lung;Lung infections;Microbial Biofilms;Military Hospitals;military injury;Military Personnel;Modeling;Motility;Multi-Drug Resistance;Mus;mutant;novel;novel therapeutics;overexpression;pathogen;pathogenic bacteria;Pathway interactions;Phenotype;Prevention;quorum sensing;Regulation;Regulatory Pathway;Regulon;Resistance;resistant strain;Role;Signal Transduction;small molecule;Testing;transcriptome;Vaccines;Variant;Virulence;virulence gene;Virulent;Work;World Health Organization

PROJECT_TITLE: Manipulating a Virulence Switch to Combat Acinetobacter baumannii Infections


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: RELEVANCE Sepsis, an overwhelming and adverse response of the body to infection, afflicts thousands of Veterans annually and kills millions globally each year. Antibiotics alone often do not suffice, and other therapies to treat the organ- damaging consequences of sepsis have been uniformly disappointing. Patients with sepsis frequently also have anemia, and the two conditions conspire to compromise oxygen distribution in the body, in turn aggravating the characteristic organ damage. In this project, we focus on uncovering mechanisms by which red blood cells modulate injury during sepsis. Our focus is on a newly recognized pathway for the exchange of molecules that act as signals between the blood cells and the blood vessel cells, and we will specifically test the role of molecules that can now be augmented when anemic patients with sepsis are transfused. We take advantage of a newly produced mouse model designed to unravel this newly recognized signaling molecule, and use innovative methods to visualize these processes in the capillaries in order to address this significant problem.

PI_NAMEs: MCMAHON, TIMOTHY J (contact)

PROJECT_TERMS: Acute Lung Injury;Address;adhesion receptor;Adhesions;Adhesives;Adoptive Transfer;Amino Acid Transporter;Anemia;Animal Model;Antibiotics;Autologous;Basement membrane;Biochemical;Blood;Blood Banks;Blood capillaries;Blood Cells;Blood Vessels;cecal ligation puncture;Cell Adhesion;Cells;Characteristics;clinically significant;comorbidity;Competence;Critical Illness;Cryopreservation;Data;Depressed mood;Endothelial Cells;Endothelium;Engineering;Erythrocytes;Event;experimental study;extracellular;Extravasation;Failure;Human;Hypoxia;Immune response;Impairment;In Vitro;in vivo;indexing;Infection;inhibitor;Injury;Innate Immune Response;innovation;Laminin;Lung;Measures;Mediating;Methods;model design;Modeling;mouse model;Mus;neutrophil;Nitric Oxide;novel;Organ;organ injury;Outcome;Oxygen;paracrine;Pathway interactions;patient population;Patients;Physiological;Population;Process;Production;randomized, clinical trials;receptor;response;response to injury;Rest;Risk Factors;Role;S-Nitrosothiols;Secondary to;Sepsis;septic;septic patients;Signal Transduction;Signaling Molecule;Specimen;System;Testing;Transfusion;Veterans;Visualization;Wild Type Mouse

PROJECT_TITLE: Aberrant RBC SNO transport and endothelial adhesion in sepsis


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The gut immune system must maintain tolerance in the steady-state while retaining the ability to rapidly induce immunity to pathogens during infection. We have found that inhibition of small intestine goblet cell associated antigen passages rapidly promotes a protective immune response characterized by activation of cellular and humoral immunity even in the absence of infection, and propose this is a physiologic response to prime the immune system to fight enteric infection. In this proposal we will identify the drivers, outcomes, necessity of this response to fight enteric infection.

PI_NAMEs: NEWBERRY, RODNEY D (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acetylcholine;Affect;Antigen-Presenting Cells;Antigens;Award;B-Lymphocytes;Bacteria;Cells;Cellular Immunity;Collection;commensal bacteria;cytokine;Data;Diet;dietary;enteric infection;Epidermal Growth Factor Receptor;Epithelium;Event;Exposure to;fighting;Gastrointestinal tract structure;Genetic;Goblet Cells;Grant;gut microbiota;Humoral Immunities;Immune;Immune response;Immune system;Immunity;imprint;improved outcome;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal homeostasis;Intestines;Lamina Propria;Ligands;Lymphoid Follicle;Lymphoid Tissue;Macrophage;Maps;Microbe;microbiota;microorganism antigen;Modeling;Monitor;Mucous Membrane;Mus;Nature;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Physiological;Plasma Cells;programs;Property;receptor;Reporter;response;Role;Small Intestinal Goblet Cell;Specificity;Stimulus;T cell response;Time;Tissue Expansion

PROJECT_TITLE: Goblet Cells in Intestinal Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(03)]


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PI_NAMEs: KREEGER, PAMELA K (contact)

PROJECT_TERMS: Affect;Biological;biomarker driven;biomarker identification;Biomedical Engineering;Biomimetics;Breast;Budgets;cancer biomarkers;cancer imaging;Cancer Model;Catchment Area;cell type;Cells;Clinical;clinical development;Clinical Trials;Collaborations;Complex;Comprehensive Cancer Center;Development;Direct Costs;Extracellular Matrix;Faculty;Fibroblasts;Fostering;Foundations;Funding;Genetic;Goals;Grant;Growth;Heterogeneity;High Prevalence;Image;imaging modality;Immune;Immunology;in vitro Model;Innovative Therapy;Institution;Instruction;Intervention;Invaded;Investigation;Investments;Leadership;Legal patent;Licensing;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;member;Mentors;Metabolism;Microfluidics;Mission;Modality;Modeling;multidisciplinary;Natural Killer Cells;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;new technology;optical imaging;Paracrine Communication;patient response;Patients;Peer Review;Physicians;Pilot Projects;Population;precision medicine;Productivity;programs;Prostate;Publications;recruit;Reproduction spores;Research;Research Priority;Research Support;resistance mechanism;response;response biomarker;Role;Science;Scientist;Strategic Planning;Stromal Cells;success;System;T-Lymphocyte;Technology;Therapeutic;therapy resistant;trafficking;treatment response;tumor;Tumor Angiogenesis;Tumor Cell Migration;tumor growth;tumor immunology;tumor initiation;tumor microenvironment;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Tumor Microenvironment


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This proposal will combine novel closed-loop image guidance methods with quantitative assessment of the secretion of cancer soluble biomarkers in body fluids to longitudinally assess Focused Ultrasound (FUS) targeted drug delivery and monitor the response to therapy. The proposed work, which will critically advance the FUS technology, aims to address critical barriers to the progress of noninvasive delivery of anticancer agents in brain tumors and facilitate the translation of this potentially transformative technology to the clinics.

PI_NAMEs: ARVANITIS, KONSTANTINOS-COSTAS  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;acoustic imaging;Acoustics;Address;Animals;Antineoplastic Agents;Biological Assay;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Tests;Blood Vessels;blood-brain barrier permeabilization;Body Fluids;Brain;Brain Neoplasms;C57BL/6 Mouse;cancer cell;Cell Death;Cell Proliferation;Cephalic;cerebrovascular;chemotherapeutic agent;chemotherapy;Clinic;Clinical;Clinical Data;Clinical Trials;clinically relevant;Computing Methodologies;contrast enhanced;cranium;design;Detection;Dimensions;Dose;Drug Delivery Systems;Drug Monitoring;Drug Targeting;effective therapy;Effectiveness;Electronics;Elements;Engineering;Experimental Models;Filtration;Focused Ultrasound;Focused Ultrasound Therapy;Genes;Glioblastoma;Glioma;Human;image guided;imaging modality;improved;in vivo;innovation;insight;Intervention;Interventional Ultrasonography;Investigation;KRAS2 gene;Location;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;mathematical model;Measurement;Measures;Mediating;Medical;Meditation;Methods;Microbubbles;minimally invasive;Modeling;Molecular;Molecular Weight;Monitor;mouse model;Mus;Mutation;Noise;novel;operation;Patients;Penetration;Pharmaceutical Preparations;Phase;Phenotype;pre-clinical;Pre-Clinical Model;prospective;Proteins;Safety;scale up;sex;Signal Transduction;spatiotemporal;Surface;System;Techniques;Technology;Testing;Therapeutic;Tissues;translational potential;Translations;treatment response;tumor;tumor DNA;Ultrasonic Transducer;vibration;Work

PROJECT_TITLE: "Transcranial FUS therapy with closed-loop US image guidance and circulating tumor DNA

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Hematology;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This project will address the need to improve domestic scientific excellence so as to ensure that the U.S. is able to engage in scientific practices that are consistent with our future needs in the areas of biomedical research, healthcare advances and education by providing training to undergraduate college students who are racial and ethnic minorities, disabled individuals and socioeconomically disadvantaged individuals. The project will i) implement strategies that strengthen education and address student needs, which impact their retention and interests leading to biomedical careers; ii) work to keep student trainees on a trajectory that will help them seamlessly transition from the undergraduate career stage to more advanced stages; and iii) instill self confidence that leads to success, which they will model for future students considering similar career pursuits, and provide opportunities for long-term mentoring to ensure achievement of their career goals.

PI_NAMEs: ABID, RUHUL ;DIAZ, JOSEPH A;HARRINGTON, ELIZABETH O (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Achievement;Address;anti-racism;Area;biomedical profession;Biomedical Research;biomedical scientist;Cardiovascular Diseases;career;cohort;Development;disability;Disabled Persons;disadvantaged background;Disease;Doctor of Philosophy;Economically Deprived Population;Education;educational atmosphere;Ensure;equity, diversity, and inclusion;ethnic minority;evidence base;experience;Exposure to;Faculty;faculty mentor;Fortification;Fostering;Funding;Future;Goals;Habits;harassment;Health;Healthcare;Hematological Disease;improved;Individual;insight;Interdisciplinary Study;interest;Investments;Lung Diseases;Medicine;Mentors;Mentorship;Modeling;National Heart, Lung, and Blood Institute;Participant;Pathway interactions;peer;peer coaching;Population;Population Heterogeneity;Process;Productivity;programs;prospective;Public Health;Qualifying;racial minority;Readiness;Recommendation;Research;Research Training;Rewards;role model;Scholars Program;Science;Scientist;Side;skills;Sleep Disorders;socioeconomic disadvantage;student mentoring;Student Selections;student training;Students;success;summer research;System;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;university student;Work;working group

PROJECT_TITLE: Short-Term Training Program to Increase Diversity in Health-Related Research


PI_NAMEs: KENNEY, SHANNON CELESTE (contact)

PROJECT_TERMS: Achievement;Affect;Attenuated;Award;Basic Science;Biochemistry;Biophysics;Cancer Biology;cancer cell;Cancer Center;cancer type;Catchment Area;Cellular biology;Clinic;Clinical;Clinical Medicine;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Cytomegalovirus;Development;Diagnosis;Diagnostic;driving force;equity, diversity, and inclusion;Extramural Activities;Faculty;functional genomics;Funding;Future;gene function;Genes;HIV;Human;improved;Individual;Infection;insight;Instruction;inter-institutional;Leadership;Maintenance;Malignant Neoplasms;McArdle Laboratory for Cancer Research;member;Mission;Molecular;Molecular Genetics;Neoplasms;neoplastic cell;next generation;novel;Oncogenic;Oncogenic Viruses;Pathway interactions;Play;prevent;Prevention;Productivity;Prognostic Marker;Program Research Project Grants;programs;Publications;recruit;Research;Research Personnel;Role;Running;Schools;Services;Systems Biology;Training;Translating;tumor;tumor progression;Tumor Promotion;Tumor Virus Infections;United States National Institutes of Health;Universities;Viral;Viral Genes;virology;Virus;virus related cancer;Wisconsin;Work

PROJECT_TITLE: Human Cancer Virology


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Nutrition;Obesity;Physical Activity;Prevention;Rehabilitation

PHR: Narrative Sedentary behavior (engaging in activities in seated/ lying posture) is very common and associates with increased mortality in people with chronic kidney disease. Current interventions in moderate to advanced chronic kidney disease have focused only on physical inactivity (lack of achieving moderate/ vigorous activity goals) rather than sedentary behavior. The current proposal will examine a novel intervention targeting sedentary behavior in chronic kidney disease.

PI_NAMEs: BEDDHU, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Accelerometer;Adherence;Agonist;American;Attenuated;Basal metabolic rate;Behavior Therapy;Body fat;Body Weight decreased;Cardiovascular Diseases;Chronic Disease;Chronic Kidney Failure;Complex;Consensus;Data;Diabetes Mellitus;Energy Metabolism;experience;Failure;Fatigue;Fatty acid glycerol esters;feasibility testing;Funding;GLP-I receptor;Goals;health related quality of life;improved;Inflammation;inflammatory marker;innovation;Institution;Insulin Resistance;Intervention;intervention effect;Lower Extremity;Measures;Metabolic;microRNA biomarkers;mortality;multidisciplinary;muscle form;Muscle function;National Institute of Diabetes and Digestive and Kidney Diseases;novel;obese patients;Obesity;Oral;Overweight;Oxidative Stress;Participant;Patient Outcomes Assessments;Performance;Persons;Physical activity;Physical Function;physical impairment;physical inactivity;Pilot Projects;placebo group;Placebos;Positioning Attribute;Posture;primary endpoint;primary outcome;protein biomarkers;psychologic;Quality of life;Randomized, Controlled Trials;Renal function;Research Personnel;resistance exercise;Risk Factors;secondary endpoint;secondary outcome;sedentary;sedentary activity;sedentary lifestyle;Sleep;standard of care;successful intervention;Testing;vigorous intensity;Walking;Well in self

PROJECT_TITLE: Sit Less, Interact and Move More (SLIMM) 2 Study

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: The current SARS-CoV-2 pandemic has demonstrated that our ability to understand new infectious diseases and to rapidly develop responses will depend on the advanced training that our current graduate students receive. Meeting this challenge will require not only research expertise, but also translational, bioengineering, policy, and science communications skills. Our HPI trainees will receive exceptional multi-disciplinary training in host-pathogen interactions in all these areas to prepare them to meet these future challenges in the public health arena.

PI_NAMEs: LEE, VINCENT T;MCIVER, KEVIN S. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: pathogen;Training

PROJECT_TITLE: Training in Host-Pathogen Interactions

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Despite advances made in the design of subunit vaccines, infectious diseases such as HIV, tuberculosis, malaria, seasonal flue and new emerging epidemics and pandemics remain major health problems highlighting the need for more innovative approaches in vaccine design. Current vaccine design strategies suffer from the lack of control over vaccine kinetics –the timing of antigen and adjuvant exposure– following immunization, that has shown to substantially impact the immune responses to vaccines. The proposal here describes marrying synthetic biology and immune-engineering approaches to design an RNA-based vaccine platform where the vaccine kinetics is controlled by orally-available small molecule drugs, and thereby enhancing the cellular and humoral responses elicited by vaccination.

PI_NAMEs: YOUSEFPOUR, PARISA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adjuvant;Antibodies;Antibody Response;Antigen Presentation;Antigens;Bolus Infusion;Cell Nucleus;Cells;Cellular Immunity;clinical translation;Communicable Diseases;Complex;constitutive expression;Cues;cytokine;Cytoplasm;design;Development;DNA;DNA-Directed RNA Polymerase;Dose;Engineering;Exposure to;FDA approved;Gene Expression Regulation;Genes;Genome;Genomics;global health;Health;HIV;HIV envelope protein;HIV-1;Humoral Immunities;Immune response;Immunity;Immunization;immunoengineering;Immunologic Memory;in vivo;Infection;Inflammatory;influenza epidemic;Injections;innovation;insight;interest;Interleukin-12;Interleukin-2;Kinetics;Laboratories;lymph nodes;Lymphocyte;Lymphoid Tissue;Malaria;Mediating;Messenger RNA;Methods;MHC Class I Genes;Modeling;Molecular;Molecular Conformation;new epidemic;new pandemic;novel;Nucleic Acid Vaccines;Nucleic Acids;Oral;Oral Administration;Outcome;pandemic potential;Patient Compliance;Pattern;Pharmaceutical Preparations;pill;Play;Production;Proteins;Replicon;replicon vaccine;Reporter;response;Risk;RNA;RNA replication;RNA vaccine;Role;Schedule;seasonal influenza;Seasons;Shapes;small molecule;Subunit Vaccines;synthetic biology;T cell response;T-Lymphocyte;Therapeutic;therapeutic DNA;tool;transgene expression;translatable strategy;translation to humans;Trimethoprim;Tuberculosis;Vaccination;vaccination strategy;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine strategy;vaccine-induced immunity;Vaccines;Work

PROJECT_TITLE: Controlling Vaccine Kinetics with Small Molecule Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Prevention;Rural Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: TRENTHAM-DIETZ, AMY  (contact)

PROJECT_TERMS: Address;Advocacy;African American;Alcohol consumption;American Indians;Breast;Cancer Burden;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Patient;cancer statistics;cancer therapy;cancer type;Catchment Area;Clinic;Clinical;clinical care;Clinical Research;Clinical Research Protocols;clinical trial recruitment;Clinical Trials;Collaborations;Communication;Communities;Community Clinical Oncology Program;community engaged research;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Data;Disparity;Dissemination and Implementation;diversity and equity;Ensure;equity, diversity, and inclusion;Ethnic Origin;evidence base;Evidence based intervention;experience;Faith-based organization;Feedback;Fostering;Funding;Goals;Government;Head and neck structure;health equity;Health Policy;Health system;Household;Human Papilloma Virus Vaccination;Human Resources;Individual;individual patient;Infrastructure;innovation;Instruction;Intervention;Investments;Laws;Leadership;leukemia;Link;Malignant Neoplasms;Media Campaign;member;Mission;Molecular Medicine;Monitor;Multiple Myeloma;NCI Center for Cancer Research;Not Hispanic or Latino;novel;Oncology;outreach;outreach program;Participant;Patient Recruitments;Patients;Policies;policy recommendation;Population;Population Sciences;precision medicine;Prevention;programs;Prostate;quitline;Race;Recommendation;Research;Research Personnel;Research Priority;Risk;Risk Factors;Risk Reduction;rural dwellers;Scientist;screening;Screening for cancer;Shapes;Smoking;statistics;Strategic Planning;Structure;surveillance data;survivorship;Testing;tobacco cessation intervention;Training;treatment trial;tumor;Underrepresented Populations;Universities;University resources;Update;Vision;Voice;ward;Wisconsin

PROJECT_TITLE: Community Outreach and Engagment


PHR: The goal of this proposal is to develop an improved therapeutic strategy for myelodysplastic syndromes (MDS). MDS is a heterogeneous group of malignancies that are diagnosed in about 15,000 people in the U.S. per year. Lower risk patients have a good prognosis and are treated with supportive care, while outcomes for higher risk patients are poor and these patients carry a risk of progression to acute myeloid leukemia (AML). Treatment options for this disease are limited, and studies aimed at finding new therapeutic strategies are needed. MDS has a distinct population of stem cells that can give rise to the disease, and targeting this population could represent a powerful tool in the treatment of MDS with the potential to eradicate the disease. Leukemia stem cells (LSCs) rely on mitochondrial function and oxidative phosphorylation for survival, making this the Achilles’ heel of LSCs and a potential target in MDS. This project will evaluate how STAT3 regulates the mitochondrial function of leukemia stem cells in higher-risk MDS.

PI_NAMEs: AMAYA, MARIA LAURA (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adverse effects;Biological Assay;cancer cell;Candidate Disease Gene;Cell Separation;Cell Survival;Cells;Classification;Clinical;Data;Development;Diagnosis;Disease;Dysmyelopoietic Syndromes;Elderly;Electron Transport;Engraftment;Gene Expression;Genes;Genetic;Genus Hippocampus;Goals;high risk;Human;IL-6 inhibitor;IL6ST gene;immunodeficiency;improved;in vivo Model;induced pluripotent stem cell;Inflammation;Inflammatory;Interleukin Activation;Interleukin-6;International;leukemic stem cell;Link;Malignant Neoplasms;Metabolic;metabolomics;Methods;Mitochondria;Mitochondrial Proteins;Molecular Genetics;Mus;Myeloproliferative disease;novel therapeutic intervention;Nuclear;Outcome;Oxidative Phosphorylation;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Phosphorylation;Phosphorylation Site;prevent;Production;Prognosis;prognostic;progression risk;Proliferating;Property;Proteins;Regulation;Research;Respiration;Risk;Role;Sampling;Serine;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Stat3 protein;stem cell population;stem cell survival;stem cells;Supportive care;Survival Rate;System;Target Populations;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;transcription factor;Xenograft procedure

PROJECT_TITLE: Identifying the Role of the IL-6/STAT3 Signaling Pathway in Higher-risk Myelodysplastic Syndrome


ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: Our Veterans are susceptible to infections with Mycobacterium tuberculosis—the causative agent of a chronic infectious disease called tuberculosis (TB), causing high morbidity and mortality. This is because the global burden of TB continues to increase with the emergence of multidrug-resistant and extremely drug resistant M tuberculosis strains, and the lack of an effective vaccine that protects adults from infection and the ensuing TB disease. The current application seeks support to develop an effective and durable vaccine that can protect our Veterans. As M tuberculosis is transmitted through aerosols and infects the lung mucosa, the challenge is to install immune effector cells at the site of infection. Our team of immunologists, biochemists, bio-engineers and M tuberculosis experts have found ways to install bacteria-specific immune effectors at the site of infection. Using this preliminary information, we will develop and test a durable vaccine against TB in a preclinical model. This work will lead to the design of a clinical vaccine against TB, and, hence, better the quality of lives of our Veterans.

PI_NAMEs: JOYCE, SEBASTIAN  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Adjuvant;Adult;Aerosols;Alleles;Antigen Presentation Pathway;Antigens;Bacteria;Binding;Biological Assay;Biomedical Engineering;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;Cessation of life;Chronic;Clinical;clinical practice;Common Epitope;Communicable Diseases;cost;COVID-19;density;design;Disease;Drug resistant Mycobacteria Tuberculosis;Effector Cell;Epitopes;flu;Generations;Goals;high throughput screening;HLA-A gene;HLA-B Antigens;Human;humanized mouse;Immune;Immunity;Immunization;Immunodominant Epitopes;immunogenic;Immunologist;improved;in vivo;Incidence;Infection;innovation;Lung;Modeling;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Multi-Drug Resistance;multidisciplinary;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanoparticle;next generation;novel;novel vaccines;pathogen;Peptides;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Publishing;Quality of life;Research;Respiratory System;response;Route;Severe Acute Respiratory Syndrome;Site;Subunit Vaccines;Surface;T cell response;T memory cell;T-Lymphocyte Epitopes;Testing;Tissues;Transgenic Mice;Transgenic Organisms;transmission process;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine delivery;Vaccine Design;Vaccines;vector;Veterans;Virulent;Virus;Work

PROJECT_TITLE: Vaccinating at Mucosal Surfaces with Nanoparticle-conjugated Antigen and Adjuvant


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Sleep Research;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Pathological anxiety during childhood is a risk factor for the development of anxiety and depressive disorders during adolescence, particularly in girls as they are twice as likely to develop these disorders after puberty. Sleep disruptions frequently co-occur with anxiety and may contribute to the pathophysiology of these common and debilitating disorders. Here, translational studies in young anxious preadolescent girls and female rhesus monkeys will examine how anxiety-related neural alterations are related to sleep physiology, with the goal of elucidating mechanisms that can be used to conceptualize new treatments for anxious children.

PI_NAMEs: KALIN, NED H (contact);TONONI, GIULIO

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Affect;Age;Amygdaloid structure;Anterior;Anxiety;Anxiety Disorders;anxiety symptoms;anxious;Arousal;Behavioral;Brain;Child;Childhood;childhood anxiety;Chronic;Clinical;Data;density;Depressive disorder;designer receptors exclusively activated by designer drugs;Development;Dimensions;Disease;Distress;DSM-V;Ecological momentary assessment;Electroencephalography;emotion regulation;Extinction;Female;Female Adolescents;fluorodeoxyglucose positron emission tomography;Frequencies;Fright;Functional disorder;Generalized Anxiety Disorder;Genetic;girls;Goals;Home;Hour;imaging modality;Individual Differences;Insula of Reil;interest;Laboratories;Learning;Life;Link;Macaca mulatta;Measures;Mediating;Memory;memory consolidation;Mental Depression;Methods;Modeling;Monkeys;Multimodal Imaging;Nature;neural;neural circuit;Neuroanatomy;neuroimaging;Neurons;Neurophysiology - biologic function;nonhuman primate;novel;novel therapeutic intervention;Pathologic;Pathological anxiety;Performance;Phenotype;Physiological;poor sleep;preadolescence;Prevalence;Psychopathology;Puberty;rapid eye movement;REM Sleep;response;Rest;Risk;Risk Factors;Role;Separation Anxiety Disorder;Sleep;Sleep disturbances;sleep physiology;sleep quality;Slow-Wave Sleep;Social Anxiety Disorder;Source;Stress;stressor;Structure;Symptoms;Telemetry;Testing;Time;translational approach;translational study;Uncertainty;Variant;Viral Vector;women versus men;Work;Youth

PROJECT_TITLE: A translational approach for identifying factors and mechanisms underlying pathological anxiety in preadolescent girls

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: Los Angeles

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative: Sparing normal cells while killing leukemic cells (harnessing the graft-versus-leukemia effect) by manipulating alloreactive T cells remains challenging in allogeneic hematopoietic stem cell transplantation (HSCT), the only curative approach for patients with high-risk acute myeloid leukemia (AML). In this proposed research, we leverage genomic and immunogenomic data obtained from patients undergoing HSCT to identify leukemia- specific neoantigens for preclinical investigation as potential therapeutic targets. The knowledge resulting from this proposed research will advance the development of personalized treatments for AML patients.

PI_NAMEs: ALACHKAR, HOUDA  (contact)

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Advanced Development;Affect;Algorithms;Allogenic;Antigen Presentation;antigen-specific T cells;Antigens;Binding;Cell Physiology;Cell surface;Cell Therapy;Cells;Characteristics;chemotherapy;Clinical;Clonal Expansion;Clone Cells;cohort;curative treatments;cytotoxic;Data;Development;Diagnosis;Diagnostic;Disease remission;disorder risk;engineered T cells;exome sequencing;Experimental Models;FDA approved;FLT3 gene;FLT3 inhibitor;Genomics;graft vs host disease;graft vs leukemia effect;Hematopoietic Stem Cell Transplantation;high risk;Immune;Immunogenomics;Immunophenotyping;Immunotherapy;In Vitro;individual variation;Investigation;kinase inhibitor;knowledge of results;leukemia;Leukemic Cell;Life;Longitudinal cohort study;machine learning method;Major Histocompatibility Complex;Mediating;mouse model;Mutation;neoantigens;next generation sequencing;Normal Cell;novel;Outcome;Patients;Peptides;personalized medicine;Population;post-transplant;pre-clinical;predict clinical outcome;prediction algorithm;predictive modeling;predictive tools;Prognosis;Proportional Hazards Models;prospective;Prospective, cohort study;prototype;receptor;receptor binding;Receptor Protein-Tyrosine Kinases;Regimen;Regulatory T-Lymphocyte;Relapse;relapse risk;Research;Risk;RNA;Sampling;Somatic Mutation;Structure;success;Surface;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;transcriptomics;Transplant Recipients;transplantation therapy;Validation

PROJECT_TITLE: Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_NAME: MEHARRY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE Enhanced interventions are needed to improve HIV appointment adherence and interconnected psychological trauma among Black youth with HIV in the Southern United States (U.S.). We will adapt and test an HIV-trauma treatment to improve outcomes for both youth with HIV and their HIV care providers in the HIV priority region of Memphis, TN, which houses the fourth highest rate of new HIV infections, with a third among youth. Proposed research activities will lay the foundation for future R-level funding and support a promising young HIV researcher to progress career development goals.

PI_NAMEs: BROWN, LESLIE LAUREN (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;anti-racism;Appointment;Area;Automobile Driving;Benchmarking;Black race;care providers;care systems;career development;Caring;Chronic Disease;Clinic;Clinical Trials Design;community based participatory research;comparative;Consensus;County;Data;design;Development;Dimensions;disease transmission;Disparity;disparity gap;Dose;Educational workshop;Effectiveness;Ensure;Epidemic;epidemic preparedness;Equity;Evidence based intervention;experience;experimental arm;Faculty;Failure;Fatigue;Feedback;Focus Groups;Foundations;Funding;Future;Goals;Grant;group intervention;Health;health equity;health equity promotion;Health equity research;Health Services Accessibility;Historically Black Colleges and Universities;HIV;HIV disparities;HIV Infections;Human immunodeficiency virus test;Human Resources;Hybrids;implementation science;improved;improved outcome;Incidence;innovation;Institution;Intervention;Interview;Justice;Lead;Leadership;Medical;Medical Records;medical schools;Mentorship;Methods;Modality;Morbidity - disease rate;Outcome;Patient Appointment;Patients;Phase;pilot trial;Population;Positioning Attribute;Post-Traumatic Stress Disorders;primary care provider;primary outcome;Production;Provider;psychological trauma;Publications;Quality of Care;Quality of life;Race;randomized, clinical trials;Reduce health disparities;Research;Research Activity;Research Design;Research Methodology;Research Personnel;resilience;Resources;response;Role;Saint Jude Children's Research Hospital;skills;Socialization;Structure;Surveys;Tennessee;Testing;Time;Training;Trauma;trauma exposure;treatment disparity;Treatment outcome;Trust;United States;United States National Institutes of Health;Viral;Youth

PROJECT_TITLE: Implementation of Trauma Informed care for Youth Living with HIV in Memphis, TN.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


PI_NAMEs: BAILEY, HOWARD H. (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Applied Research;Area;authority;Award;Basic Science;Big Data;big-data science;biomarker driven;Breast;Caliber;cancer biomarkers;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer imaging;cancer immunotherapy;Cancer Model;cancer therapy;career;Clinical;Clinical Informatics;Clinical Research;Clinical Sciences;Communities;Comprehensive Cancer Center;Development;Diagnostic Imaging;Disease;diversity and inclusion;Early Diagnosis;Education;Education Projects;end of life;Etiology;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Future;Goals;Grant;Guidelines;Head and Neck Cancer;Hematopoietic Neoplasms;Image;Immunology;Immunotherapy;Informatics;innovation;Institution;Instruction;Intervention;Investments;Knowledge;Leadership;leukemia;Malignant Neoplasms;Maps;member;Mentors;metabolomics;Minority Recruitment;Multiple Myeloma;Nursing Faculty;outreach;palliative;Peer Review;Pilot Projects;Play;population based;Population Sciences;Prevention;Process;Productivity;programs;Prostate;Proteomics;recruit;Recruitment Activity;Research;Research Personnel;Research Priority;Resource Sharing;Resources;Role;Science;Strategic Planning;success;Supportive care;survivorship;Teacher Professional Development;tenure track;theranostics;Training;Training and Education;translational genomics;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: Developmental Funds

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  The  genetics  revolution  and  the  associated  advances  in  genome  sciences  are  fundamentally  reshaping  the  world  during  the  21st  century.  To  accommodate  these  remarkable  advances,  modernization  of  training  is  needed,  which  includes  recruiting,  mentoring,  and  training  individuals  for  a  diverse  workforce.  The  new  scholars  will  contribute  to  diverse  careers  where  doctoral- level  geneticists  and  genomicists  will  be  increasing  essential  leaders  and  team  members  to  advance  biomedical  sciences  in  research  and research- related  areas  to benefit society.

PI_NAMEs: ADELMAN, ZACH N. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Genetic;pre-doctoral;Training

PROJECT_TITLE: Diverse Predoctoral Training in Genetics