NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SINAI HEALTH SYSTEM

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X5

PHR: Project Narrative For this Ancillary R01 study proposal, we will be working with the NIDDK IBD Genetics Consortium to apply the latest high-throughput omics approaches to one of the largest post-operative Crohn’s disease (CD) cohort to better understand the pathophysiology of CD. This proposal focuses on better elucidating how the complex relationship between host genetics, microbial and immune factors contribute to recurrence of CD from a “disease-free state” after resection of disease. Through the insights gained, we hope to reduce the risk of post- operative CD recurrence, change the nature course of disease, and improve the quality of life of individuals affected by CD.

PI_NAMEs: LEE, SUN-HO  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Ancillary Study;Antibodies;Antibody Repertoire;antigen detection;Antigens;antimicrobial;biobank;Bioinformatics;Biological Assay;Biological Products;Biological Response Modifier Therapy;biomarker discovery;Biopsy Specimen;Blood specimen;Clinical;cohort;Communities;Complex;Complication;contig;Crohn's disease;Data;Defect;Dependence;Development;Disease;Environmental Risk Factor;Epithelium;Epitopes;Event;Excision;Feces;Fingerprint;follow-up;Frequencies;Functional disorder;functional genomics;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;genetic variant;Genome;genome analysis;genome wide association study;genomic signature;Goals;gut inflammation;gut microbes;gut microbiome;HLA-DRB1;host-microbe interactions;Ileal Diseases;Immune response;immunogenic;Immunologic Factors;improved;Individual;Inflammatory Bowel Diseases;innovation;insight;Intestines;LRRK2 gene;Maps;Metabolic;Metabolism;metabolome;metabolomics;metagenome;Metagenomics;Methods;microbial;microbial community;microbial composition;microbiome;microorganism antigen;Modeling;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;new technology;non-genetic;novel;novel strategies;Pathogenesis;Patient Recruitments;Patients;Perioperative;Phage Display;Phase;Phenotype;polygenic risk score;Postoperative Period;postoperative state;prevent;Procedures;Process;prospective;Prospective Studies;Proteome;Quality of life;reconstruction;Recovery;Recurrence;Recurrent disease;Reporting;Research;Research Project Grants;Ribosomal DNA;Risk Reduction;risk variant;sample collection;Serum;Shotguns;small molecule;stool sample;Taxonomy;Techniques;Technology;Time;tool;transcriptome;Translations;Viral;whole genome;Work

PROJECT_TITLE: Understanding the Interaction between Host Genetics, Immune response, and Gut Microbes in Post-operative Recurrence of Crohn's disease


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Immunotherapy;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Activation of the innate immune system has been recognized as a significant component of numerous forms of neurodegenerative disease. This project aims to characterize the factors influencing microglia, key mediators of inflammation in the retina, to switch from homeostatic to proinflammatory functions as part of disease progression in age-related macular degeneration. Using novel methods for gene knockout of key pathways in human stem-cell derived microglia-like cells, single-cell RNA sequencing analysis, and highly multiplexed molecular mapping in tissue with digital histologic analysis, this work will identify tissue microenvironment factors and immune checkpoints representing novel therapeutic targets for retinal degeneration.

PI_NAMEs: DISTASIO, MARCELLO MICHAEL (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Affect;Age related macular degeneration;apolipoprotein E-2;Astrocytes;Bar Codes;Basal lamina;Biological Assay;Biology;Blindness;Blood Vessels;Bruch's basal membrane structure;career;career development;Cell Communication;Cell Nucleus;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Central Nervous System;Chairperson;Characteristics;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;cytokine;Data;Deposition;design;Development;Diffusion;digital;Disease;Disease associated microglia;Disease Progression;Drusen;Elderly;Elements;Environment;Epitopes;Exhibits;experience;experimental study;extracellular;Future;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genomics;glial activation;Goals;Histologic;histological image;Hospitals;Human;human induced pluripotent stem cells;human stem cell-derived;Image Analysis;immune checkpoint;Immunobiology;Immunology;In Situ;indexing;Individual;induced pluripotent stem cell;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Innate Immune System;Investigation;K-Series Research Career Programs;knock-down;Knock-out;knockout gene;Knowledge;large datasets;Lesion;Lipids;Maps;Mediating;Mediator;medical schools;Mentors;Methods;Microglia;Molecular;Molecular Profiling;monocyte;multiple omics;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;Neurologist;Neurology;Neurons;Neurosciences;new therapeutic target;novel;Ophthalmology;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phagocytes;Phenotype;Physical condensation;Population;professor;programs;Progressive Disease;Proteins;Research;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;RNA;RNA analysis;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Structure of retinal pigment epithelium;Techniques;Technology;Testing;Tissues;Transcription Alteration;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;TREM2 gene;TYROBP gene;Up-Regulation;vision science;Work

PROJECT_TITLE: Mechanisms of proinflammatory glial activation in retinal degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: SYRACUSE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE While some genes can increase the risk of disease, other genes may reduce the effect of these risk genes as well as the effect of environmental factors. In this study, we will identify genetic variants that contribute to resilience to chronic obstructive pulmonary disease (COPD) by attenuating the effects of genetic risk variants and cigarette smoking. This will result in greater understanding of the ways that genetic factors contribute to variable disease risk, and this information might be used to better predict risk for COPD and identify new treatments.

PI_NAMEs: GHOSH, AUYON  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Award;biobank;Bioinformatics;Biological;Biology;Biometry;Blood;career;career development;chest computed tomography;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical;clinical heterogeneity;Clinical Management;Complement;Data;data resource;Data Sources;Development;Diagnosis;Disease;disease model;disorder risk;Environmental Exposure;Environmental Risk Factor;experience;Gene Expression;Gene Expression Profile;gene network;Generations;Genes;Genetic;genetic association;Genetic Risk;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Goals;Heterogeneity;High-Throughput Nucleotide Sequencing;Image;improved;Individual;innovation;Knowledge;Learning;Lung;Machine Learning;machine learning algorithm;Mentors;Methodology;Methods;mortality;multiple omics;National Heart, Lung, and Blood Institute;novel;Pathway interactions;Phenotype;polygenic risk score;potential biomarker;precision medicine;prevent;Procedures;programs;Public Health;pulmonary function;Research;Research Design;Research Personnel;Residual state;resilience;respiratory;Respiratory Disease;respiratory morbidity;responsible research conduct;Risk;Risk Factors;risk prediction;risk variant;Schizophrenia;Scientist;Single Nucleotide Polymorphism;skills;Smoking;SNP genotyping;Source;Structure of parenchyma of lung;success;Techniques;Testing;Training;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Genetic and Transcriptomic Resilience in Chronic Obstructive Pulmonary Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The short-interval intracortical inhibition (SICI) is a biomarker of brain excitability that can be readily obtained using non-invasive transcranial magnetic stimulation (TMS). Higher SICI scores – indicating reduced inhibition – are consistently reported in prior studies of schizophrenia; yet the clinical impact and implications of this finding are unknown since there is little evidence of the neural systems related to SICI, and how SICI may relate to clinical variables such as the extent of cognitive impairment in schizophrenia. This proposal aims to evaluate the cognitive and neural correlates of SICI in schizophrenia and conducts a pilot mechanistic clinical trial aimed at enhancing SICI in schizophrenia to identify novel targets for treatment in future clinical research studies.

PI_NAMEs: HARE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Advisory Committees;Aftercare;Anterior;Biological Assay;Biological Markers;Brain;brain circuitry;Brain region;career;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;cognitive control;cognitive neuroscience;cognitive performance;cognitive testing;Communication;Computer Models;Consensus;Data;Data Analyses;design;Diagnosis;Equilibrium;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;imaging modality;Impaired cognition;improved;indexing;innovation;Insula of Reil;Intervention;Intervention Studies;Link;Literature;MATRICS Consensus Cognitive Battery;Measures;Mentors;Methods;Motor;Motor Cortex;Motor Evoked Potentials;Motor Pathways;neural;neural circuit;neural correlate;neuroimaging;neurophysiology;novel;Participant;Patients;Performance;Persons;Physiologic pulse;Prefrontal Cortex;Randomized;repetitive transcranial magnetic stimulation;Reporting;Research;Research Design;Research Personnel;research study;Rest;Sample Size;Sampling;Schizophrenia;Short-Term Memory;Signal Transduction;Signs and Symptoms;Specificity;Stimulus;System;Task Performances;Testing;theories;therapy design;Training;Transcranial magnetic stimulation;Variant;Work

PROJECT_TITLE: Cognitive and Neural Correlates of TMS Motor Intracortical Inhibition in Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (92)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The proposed Hybrid Type II effectiveness-implementation trial aims to comprehensively evaluate the clinical effectiveness of a multi-level, integrated intervention while simultaneously assessing implementation outcomes when delivered across primary care settings for patients with hypertension in urban Vietnam. If successful, this study has great potential for nationwide scalability and sustainability to address gaps in hypertension control in urban Vietnam.

PI_NAMEs: NGUYEN, HOA  (contact);TRAN, OANH ;WANG, BO

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Address;Adoption;Adult;aged;Anti-Hypertensive Agents;behavior change;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Characteristics;Cities;Clinical;Clinical effectiveness;Collaborations;Communities;Community Health Aides;comorbidity;comparison group;computerized;cost effective;cost utility analysis;Data;Diagnosis;Disease;disorder risk;effectiveness outcome;effectiveness/implementation trial;Enrollment;Epidemiology;Evaluation Studies;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;follow-up;Funding;group intervention;Health;Health care facility;Health Technology;Healthcare Systems;Heavy Drinking;Home;Home Blood Pressure Monitoring;Hybrids;Hypertension;hypertension control;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;innovation;Integrated Delivery of Health Care;Intervention;intervention delivery;intervention program;Interview;Learning;Letters;Life Style;Link;Massachusetts;medical schools;medication compliance;mHealth;Modeling;Monitor;Morbidity - disease rate;mortality;motivated behavior;multidisciplinary;Multimedia;Needs Assessment;Participant;patient engagement;Patients;Persons;Pharmaceutical Preparations;Phase;physical inactivity;Physicians;Policies;Population;Prevalence;Prevention;primary care setting;Process;programs;Quality of life;Randomized;Reporting;Research;Research Personnel;Risk Factors;Rural;Rural Population;Self Efficacy;Services;Site;social culture;socioeconomics;Strategic Planning;Stress;Structure;Surveys;System;Testing;Text Messaging;Time;Training;trend;Unhealthy Diet;United States National Institutes of Health;Universities;Urban Community;Urban Population;urban setting;Urbanization;Vietnam;Vietnamese;Voice;Work

PROJECT_TITLE: Conquering Hypertension in Urban Vietnam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Uncontrolled blood pressure is the leading cause of heart disease and stroke. The purpose of our study is to assess the impact of health coaching and navigation help by tele-community health workers on death and hospitalization risk for patients with severe hypertension.

PI_NAMEs: AFZAL, BADAR ;KHAN, UNAB INAYAT;RAZZAK, JUNAID ABDUL (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adherence;Adopted;Adult;Affect;Ambulatory Care Facilities;Anti-Hypertensive Agents;Asia;Awareness;behavior change;behavioral health;Blood Pressure;blood pressure control;Blood Pressure Monitors;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Clinic;Clinical;Clinical effectiveness;Communities;Community Health Aides;Complex;Consolidated Framework for Implementation Research;Data;Death Rate;design;Diagnosis;disorder control;disorder prevention;effective intervention;Enrollment;Ensure;Event;evidence base;expectation;experience;Exposure to;Funding;Goals;Government;Health;Health Benefit;Health Food;Health Resources;Health Sciences;Health system;Healthcare Systems;Heart Diseases;High Prevalence;high risk;Home visitation;hospital admission rate;Hospitalization;hospitalization rates;Hypertension;hypertension control;implementation context;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;improved outcome;Individual;Infrastructure;Intervention;Knowledge;Life Style;Lived experience;low and middle-income countries;Measures;medication compliance;Methods;Modeling;mortality;multi-component intervention;multidisciplinary;Myocardial Infarction;Neighborhoods;Outcome;Pakistan;Participant;Patient Care;Patient Discharge;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physical activity;pilot test;Policy Maker;pollutant;Population;Primary Care;Primary Health Care;prospective;Protocols documentation;Provider;Public Health;Randomized, Controlled Trials;Research;Research Design;Resources;Risk;secondary outcome;social cohesion;Stress;Stroke;stroke risk;Structure;telehealth;Testing;Time;United States National Institutes of Health;urban area;Urban Health;Urban Population;Weight;Work

PROJECT_TITLE: Coaching and Navigation by CHWs through Telehealth for High-risk Hypertension


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: This proposal aims to continue training and mentoring underrepresented junior scientists/clinicians and those with disabilities by enhancing their research skills in cardiovascular health disparities. The ultimate goal in increasing diversity among the ranks of underrepresented scientists/clinicians, is an important step towards alleviating heart disease related health disparities. In the 17 years since its inception at Brooklyn SUNY Downstate Health Sciences University, the program has trained 129 underrepresented junior faculty, the majority of them are now funded or on their way to obtaining research funding and pursuing independent academic careers.

PI_NAMEs: BOUTJDIR, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Achievement;Advisory Committees;Applications Grants;behavioral health;Cardiovascular Diseases;cardiovascular health;career;Career Choice;career development;Climacteric;Communities;community based participatory research;community based research;community organizations;Data;disability;disease disparity;Disparity;Education;expectation;experience;Faculty;Feedback;Financial Support;Formulation;Funding;Goals;Grant;Health Disparities Research;health disparity;Health Sciences;Heart Diseases;improved;innovation;Institution;interdisciplinary approach;Investments;Knowledge;Laboratories;Leadership;Learning;Literature;Medical center;Medical Education;meetings;member;Mentors;Minority;Mission;National Heart, Lung, and Blood Institute;neighborhood disadvantage;New York;Participant;peer coaching;Peer Review;Peer Review Grants;Persons;Preventive Medicine;Productivity;Program Effectiveness;programs;Public Health;Publications;Qualifying;recruit;Reduce health disparities;Research;Research Project Grants;Research Training;Role;satisfaction;Scientific Inquiry;Scientist;Secure;skill acquisition;skills;Study Section;success;summer institute;tool;Training;Underrepresented Populations;United States National Institutes of Health;Universities;urban setting;webinar;Writing

PROJECT_TITLE: Program to Increase Diversity in Cardiovascular Health-Related Research(PRIDE-CVD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O2)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Precision Medicine;Sepsis

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The prevalence of extended-spectrum β-lactamase producing Enterobacterales (ESBL-E) has increased by over 50% in the US over a 5-year period - with upwards of 30% mortality associated with ESBL-E bloodstream infections (BSI). Our preliminary data across Enterobacterales species indicate that 3 ESBL gene families comprise ~99% of ESBLs (i.e., blaCTX-M [60%], blaSHV-variants [25%], and blaTEM-variants [15%]); however, little progress has been made to characterize the prevalence of non-CTX-M gene families across Enterobacterales species and it is unknown if piperacillin-tazobactam may be an effective carbapenem-sparing treatment option for SHV and TEM ESBL-E infections. We would like to investigate if a mechanistic-based treatment approach (i.e., optimal antibiotic treatment selection is dependent on the ESBL gene identified) will improve the outcomes of patients by (1) characterizing the epidemiology of ESBL genes in a multicenter cohort of 2,000 consecutive clinical Enterobacterales BSI isolates and (2) determining if meropenem is the preferred treatment for ESBL-producing Enterobacterales BSI regardless of the ESBL gene family present.

PI_NAMEs: TAMMA, PRANITA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: accurate diagnostics;Address;Adopted;Alleles;Antibiotic Therapy;Antibiotics;Bacteria;beta-Lactamase;beta-Lactams;Biochemical;carbapenem resistant Enterobacterales;carbapenemase;Carbapenems;Ceftriaxone;Cephalosporins;Cessation of life;Clinical;Clinical Trials;cohort;Collection;Cyclophosphamide;Data;Diagnosis;Discrimination;effective therapy;Ensure;Enzymes;Epidemiology;Escherichia coli;Exhibits;Extended Spectrum Beta lactamase producing Enterobacterales;Family;Gene Family;Generations;Genes;Genotype;Health Care Costs;Hospitalization;Hospitals;Hydrolysis;improved;improved outcome;Infection;inhibitor;Klebsiella pneumoniae;Knowledge;Laboratories;Low Prevalence;Maryland;Meropenem;Microbiology;Molecular;Molecular Epidemiology;molecular targeted therapies;mortality;novel;Observational Study;optimal treatments;Patient-Focused Outcomes;Patients;Phenotype;Piperacillin-Tazobactam;precision medicine;Predisposition;Prevalence;Probability;Production;Proxy;Public Health;resistance mechanism;Science;Selection for Treatments;Sepsis;Subgroup;Testing;Translating;treatment strategy;trial comparing;Variant;Work

PROJECT_TITLE: Identifying Optimal Antibiotic Treatment for Non-CTX-M-Producing ESBL Bloodstream Infections

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Many of the symptoms of long COVID [i.e., post-acute sequelae of SARS-CoV-2 infection (PASC)], including learning and memory impairments, fatigue, anxiety, and depression, are likely mediated through the central nervous system. A protracted reaction to the virus, possibly via prolonged inflammation, may contribute to cognitive and mood impairments. Prospective neuropsychiatric, neuroimaging, and biological data will be collected to identify biomarkers, genetic risk factors, and clinical endpoints associated with neuropsychiatric PASC (neuro-PASC) progression or severity, and biomarkers for promoting brain repair and attenuating those symptoms. This research will advance our understanding of the long-term effects of COVID-19 on neuropsychiatric functions, identify clinically relevant biomarkers, provide evidence-based guidance for clinicians working with this unique population, and facilitate the development of therapeutic interventions to treat neuro- PASC and will be a unique contribution to overall VA priorities and Veteran health.

PI_NAMEs: LOFTIS, JENNIFER M (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adhesions;Adverse effects;Americans with Disabilities Act;Anatomy;Anisotropy;Anxiety;Apolipoprotein E;apolipoprotein E-4;Attention;attenuation;Behavior;Biological;Biological Markers;biomarker identification;Blood;Blood specimen;Brain;brain cell;brain repair;Cells;Central Nervous System;Chemotaxis;Clinical;clinical practice;clinically relevant;Cognition;Cognitive;cognitive process;Communicable Diseases;Coronavirus;COVID-19;COVID-19 severity;COVID-19 susceptibility;cytokine;Data;Decision Making;Development;Diffusion Magnetic Resonance Imaging;disability;discounting;Disease;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;evidence base;Exclusion Criteria;executive function;exhaust;experience;Fatigue;Flow Cytometry;Functional impairment;Future;genetic risk factor;Genotype;Health;Healthcare Systems;Hormones;Human;Hydrocortisone;Immune;Impaired cognition;Impairment;In Vitro;inclusion criteria;Individual;Infection;Inflammation;Inflammatory;Injury;Interferons;Knowledge;Learning;Long COVID;long term consequences of COVID-19;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;Medical center;member;Memory;Memory impairment;Mental Depression;Mental Health;Monitor;Moods;morphometry;multidisciplinary;multiplex assay;Nervous System Physiology;neuroimaging;Neurologic;neurologic sequelae of COVID-19;Neurologic Symptoms;neurophysiology;neuropsychiatric symptom;neuropsychiatry;Neuropsychology;Online Systems;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;persistent symptom;Phenotype;Plasma;Plasma Proteins;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;prospective;Protein Isoforms;Proteomics;Publishing;Reaction;Recommendation;Recording of previous events;Registries;Reporting;Research;Resources;Rest;Risk;Saliva;saliva sample;Sampling;SARS-CoV-2 infection;severe COVID-19;Severities;Signal Pathway;Small Inducible Cytokine B9;Stress;Structure;Symptoms;T-Lymphocyte;Tennessee;Testing;therapeutic development;therapeutic evaluation;Therapeutic Intervention;Thick;Time;time use;TNF gene;tractography;Translations;Vaccination;Veterans;Viral Load result;virology;Virus

PROJECT_TITLE: Immune-mediated pathogenic mechanisms of Neuro-PASC in Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBC-F (01)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE WENCESLAU, CAMILLA F.  Growing evidence supports a robust and likely causal association between hypertension and Alzheimer's disease (AD). Here we claim that the causative connection of these conditions is an exacerbated endothelial-to- mesenchymal transition and, subsequently, synthesis of amyloid-β protein oligomers to form amyloid plaques. We will reprogram and rejuvenate endothelial cells to prevent endothelial-to-mesenchymal transition and treat AD and hypertension.

PI_NAMEs: WENCESLAU, CAMILLA FERREIRA (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Abeta synthesis;Acceleration;Adopted;Adult;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;angiogenesis;Animals;Anti-Hypertensive Agents;Area;Arteries;Blood flow;blood pressure control;blood pressure intervention;Blood Vessels;Brain;Calcium;Cardiovascular Diseases;Cell Reprogramming;Cells;Cellular Stress;cerebral hypoperfusion;Dementia;Deterioration;Development;Disease;Disproportionately impacts women;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Exploratory/Developmental Grant;Functional disorder;Goals;Grant;Head;Heart;Heart failure;Human;human old age (65+);human tissue;Hypertension;hypertensive;Impaired cognition;Incidence;innovation;Intervention Trial;Laboratories;large datasets;men;Mesenchymal;misfolded protein;Mus;neural;Neurofibrillary Tangles;Neurons;Neurotoxins;nonalzheimer dementia;older adult;Organ;overexpression;Perfusion;Persons;Phenotype;Plasma;Play;pluripotency;Predisposition;pressure;prevent;Process;programs;protein oligomer;Rejuvenation;repaired;Research;Risk;Risk Factors;Rodent;Role;Senile Plaques;sex;single nucleus RNA-sequencing;Solid;tau Proteins;Testing;Time;transcription factor;transdifferentiation;Vascular Diseases;Vascular Endothelial Cell;Woman

PROJECT_TITLE: Reprogramming endothelial cells to prevent and treat Alzheimer disease (AD) and Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: More than 700,000 people are diagnosed with liver cancer and 600,000 people die each year worldwide; the incidence is increasing in the US and it is estimated that 42,220 new cases will be diagnosed and 30,200 people will die of liver cancer in the next year. Part of the increased incidence in the US is thought to be due to HCV infections acquired during the 1960s and 1970s but aside from viral infection, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and cirrhosis are major risk factors for liver cancer. The 5-year survival rate is only 18% underscoring the lack of effective therapies in liver cancer so a detailed understanding of the mechanisms involved in triggering liver disease and hepatocellular carcinoma would greatly help the prevention and treatment of liver cancer.

PI_NAMEs: WEBSTER, NICHOLAS J (contact)

PROJECT_TERMS: adult obesity;Alcohol consumption;Alcoholic Liver Cirrhosis;Alternative Splicing;Apoptosis;Binding;cancer risk;Cause of Death;Cell Physiology;Cell Reprogramming;Chemoembolization;Chronic Hepatitis B;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Coupled;Cryosurgery;Development;Diagnosis;Disease;Disease Progression;DNA;DNA Damage;DNA Repair;effective therapy;efficacious treatment;Eligibility Determination;Engineering;Event;Excision;Experimental Genetics;experimental study;fatty liver disease;Fibrosis;Functional disorder;Gene Expression;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Genomics;glucose metabolism;Goals;Growth;Hepatitis B Vaccination;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatocyte;high risk;Histologic;Human;Hybrids;IGF2 gene;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;Inflammation;innovation;Insulin Receptor;Knowledge;lipid metabolism;Liver;Liver diseases;Liver Fibrosis;liver inflammation;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolic syndrome;microwave ablation;Modeling;Molecular;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;obese person;Obesity;Oncogenic;Oncoproteins;Pathogenesis;Patients;Persons;pharmacologic;Polyploidy;Population Attributable Risks;Precancerous Conditions;preclinical study;prevent;Prevention;Primary carcinoma of the liver cells;problem drinker;Process;Progression-Free Survivals;Proliferating;protein expression;Protein Isoforms;Proteins;Radioembolization;Recurrence;repaired;Residual Neoplasm;Resolution;restraint;Risk;Risk Factors;RNA;RNA Splicing;Role;Series;Signal Pathway;Signal Transduction;Source;Survival Rate;Testing;Thermal Ablation Therapy;Tissues;Transplantation;tumor;Variant;Viral;Virus Diseases

PROJECT_TITLE: IGF2 causes DNA damage in liver cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: Our goal is to develop better therapies for Alzheimer’s disease (AD). Our published results show that pharmacologically high doses of thiamine (vitamin B1) are effective in mouse models of AD and produce encouraging clinical benefit in AD patients. The research will discover the mechanism of the thiamine sensitivity with measures in AD autopsy brain and in brain and blood samples from mice with low and high thiamine in order to develop better therapies.

PI_NAMEs: FLOWERS, SARAH ANN;GIBSON, GARY E (contact);ZHANG, SHENG

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Advanced Glycosylation End Products;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapy;Animal Disease Models;Antibodies;apolipoprotein E-3;apolipoprotein E-4;Attenuated;Autopsy;benphothiamine;Biological;Biological Markers;Blood;Blood specimen;Brain;Brain region;Clinical;Clinical dementia rating scale;Clinical Trials;crosslink;Data;Development;Diabetes Mellitus;diagnostic biomarker;Disease;disease prognostic;dosage;Dose;Effectiveness;Etiology;Exposure to;Functional disorder;Funding;genetic risk factor;Genotype;Glucose;glucose metabolism;glycation;Glycosylated hemoglobin A;Goals;improved;Knock-in Mouse;Link;Lipids;Location;macromolecule;Measures;Medicine;Memory;Memory Loss;Metabolic;Metabolic dysfunction;Modification;mouse model;Multicenter Trials;Mus;Nature;neurofibrillary tangle formation;Neurofibrillary Tangles;novel;novel therapeutic intervention;Participant;Pathology;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Plasma;Prediabetes syndrome;Process;Prognostic Marker;Proteins;Proteomics;Publishing;Research;response;Role;Severity of illness;sex;Signal Pathway;Site;success;sugar;Surveys;symptomatic improvement;Testing;Therapeutic;Therapeutic Trials;therapeutically effective;Thiamine;Thiamine Deficiency;Thiamine Pyrophosphate;translational medicine;Trust

PROJECT_TITLE: Mechanistic links between the benefits of pharmacologically high thiamine (vitamin B1) in Alzheimer's disease to Advanced Glycation Endproducts (AGE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative Glaucoma is a blinding disease world-wide, but for reasons that are unclear, African- Americans are at disproportionate risk, yet, very little is known about this disease in this population. Therefore identification of IOP-regulation in African Americans is a major task that must to be overcome before therapeutic interventions for the treatment of glaucoma in this population can be developed. Therefore the overall goal is to elucidate the cellular, molecular and biochemical mechanisms that regulate IOP; African American and Non-Hispanic Whites donor eyes will be used in this study, aimed at identifying novel therapeutic targets for the treatment of glaucoma.

PI_NAMEs: ELLIS, DORETTE Z (contact);MILLAR, JOHN CAMERON

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Address;Africa;African American;African American population;African ancestry;Anterior eyeball segment structure;Aqueous Humor;Autopsy;Biochemical;Biological Assay;Biological Models;Blindness;Cadherins;Cells;cohort;Cytoskeleton;Data;Development;Disease;Ethnic Origin;Eye;Functional disorder;Gel;Gene Expression;Genes;Genetic Risk;genome wide association study;Glaucoma;Goals;Grant;health disparity;high intraocular pressure;high risk;human tissue;Immunohistochemistry;Immunoprecipitation;In Vitro;in vivo;interest;Left;Link;Measures;Mediating;Molecular;new therapeutic target;Not Hispanic or Latino;novel;Organ Culture Techniques;particle;Pathway interactions;Patients;Perfusion;Persons;Physiologic Intraocular Pressure;Population;Population Decreases;Primary Open Angle Glaucoma;Protein Family;Protein Kinase;protein kinase inhibitor;Proteins;Regulation;Relaxation;Research;Resistance;rho;rho GTP-Binding Proteins;Risk;risk variant;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Small Interfering RNA;Stains;Stress Fibers;Structure of sinus venosus of sclera;System;Testing;Therapeutic;Therapeutic Intervention;therapy development;Time;Trabecular meshwork structure;Vimentin;Work

PROJECT_TITLE: Targeting FMNL2/Rho-GTPase Pathway for IOP Regulation in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Preterm infants have immature gastrointestinal function, small bile acid pools, and adrenal insufficiency that limit their development and response to enteral nutrition. Fibroblast growth factor 19 (FGF19) is a potent fetal growth factor that is upregulated postnatally and functions to regulate bile acid homeostasis. In this proposal, we seek to determine the impact of perinatal glucocorticoids and FGF19 on gastrointestinal, hepatic and metabolic outcomes in preterm pigs.

PI_NAMEs: VONDEROHE, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adrenal gland hypofunction;Adult;Agonist;Bile Acid Biosynthesis Pathway;Bile Acids;Bioinformatics;Birth;Body fat;career;Cell Culture Techniques;Cesarean section;clinical practice;clinically relevant;Coculture Techniques;cohort;comorbidity;Development;Digestion;Distal;Dose;Endocrine;Enteral;Enteral Feeding;Enteral Nutrition;Exhibits;Exposure to;Family suidae;Fat Body;Fatty acid glycerol esters;feeding;Fetal Growth;FGF19 gene;Fibroblast Growth Factor Receptors;Functional disorder;gastrointestinal;gastrointestinal function;Glucocorticoids;Goals;Growth;Growth and Development function;Growth Factor;Hepatic;Hepatocyte;Histologic;Homeostasis;Human;human model;Hydrocortisone;ileum;Image;improved;In Vitro;in vivo;Infant;Infant Development;Infant Mortality;infant nutrition;Intervention;Intestines;large datasets;Liver;Lung;Measurement;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Modality;Molecular;mRNA Expression;Mus;muscle hypertrophy;Neonatal;novel;Nutritional;organ growth;Outcome;Pathway interactions;Perinatal;perinatal period;Pharmacologic Substance;Physiological;Physiology;Plasma;porcine model;postnatal;Premature Birth;Premature Infant;prenatal;preterm newborn;programs;promoter;Protein Biosynthesis;Proteins;Proxy;Reagent;receptor;Regulation;Research;Research Personnel;Respiratory physiology;response;Risk;Role;Schedule;Signal Pathway;Signal Transduction;Skeletal Muscle;skills;Small Intestines;Supplementation;System;Techniques;Therapeutic;Therapeutic Effect;Thinness;Tissues;Training;Transcriptional Regulation;United States;Vagina;Vaginal delivery procedure;Weight Gain

PROJECT_TITLE: DEVELOPMENTAL REGULATION OF FIBROBLAST GROWTH FACTOR-19 IN NEONATES

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


FUNDING_MECHANISM: OTHERS

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: The burden of depression, both from a societal and economic standpoint, ranks second only to ischemic heart disease. The World Health Organization projects that depression is the leading cause of disability, worldwide. Depression and suicide (44/day) are particularly prevalent in military returning from deployment and the population of Veterans they become. As many as one third are resistant to antidepressants and they are at greatest risk for suicide. We have identified a proteomic biosignature for depression and responsiveness to therapy. Most recently, we have learned that platelets from depressed subjects show this biomarker and those from subjects undergoing successful treatment revert to “normal”. We are currently doing a larger- scale study of this is a veteran population. Knowledge gained from this study should help to develop a rapid and inexpensive screen for depression and antidepressant responsiveness, and create a platform for development of novel antidepressant compounds.

PI_NAMEs: RASENICK, MARK M. (contact)

PROJECT_TERMS: active duty;Adenylate Cyclase;Advocacy;Advocate;American;Anguish;Animal Model;anti-depressive agents;antidepressant effect;Area;Autopsy;Award;Biological Markers;Biology;Biomedical Research;biosignature;Blood Cells;Blood Platelets;Blood Tests;Brain;Brain Diseases;career;Cells;Chemicals;Chimeric Proteins;Chronic;Clinical;Clinical Research;Collaborations;completed suicide;Congresses;Cultured Cells;Cyclic AMP;Cytoskeleton;Data;Depressed mood;Depression screen;Depressive disorder;Development;disability;Disease;Disease remission;drug development;Economics;Elements;Event;experience;Fish Oils;Fright;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Hallucinogens;Health;Heterotrimeric GTP-Binding Proteins;Human;human subject;In Vitro;Individual;insight;Investigation;Justice;Ketamine;Knowledge;Laboratories;Learning;Link;Lipids;Los Angeles;Marketing;Measures;Membrane Microdomains;Mental Depression;Mental disorders;Mental Health;Military Personnel;military veteran;Molecular;Mood Disorders;Movement;Myocardial Ischemia;N-Methyl-D-Aspartate Receptors;Nature;nerve stem cell;Neuroglia;Neurons;Neurosciences;novel;Omega-3 Fatty Acids;Paper;Pathway interactions;Patients;peace;Peripheral;Pharmaceutical Preparations;Policies;Positioning Attribute;postsynaptic;presynaptic;Proteomics;Psychiatry;Publishing;Rapid screening;Research;Resistance;response;sabbatical;Science;Science Policy;Scientific Societies;Scientist;Screening procedure;Shapes;side effect;Signaling Protein;Site;Social Justice;social stigma;Social Work;suicidal risk;Suicide;Synapses;System;Therapeutic;Time;Tissues;Translating;treatment duration;treatment response;Tubulin;uptake;Veterans;Wood material;Work;World Health Organization

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Telehealth

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative This project will provide Dr. Frank Schwebel with training in mindfulness-based interventions, psychosocial and pharmacological treatment approaches for opioid use disorder, advanced mobile health approaches and quantitative methods, and research ethics. The proposed research will evaluate the efficacy of a microrandomized intervention designed to increase state mindfulness, decrease craving, and increase self- efficacy among individuals who take daily medication for an opioid use disorder. Together, the well-integrated research and career development plans will support Dr. Schwebel’s independent research program focused on developing mobile health treatments for opioid use disorder.

PI_NAMEs: SCHWEBEL, FRANK  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: acceptability and feasibility;acute care;adaptive intervention;addiction;Address;Adherence;adherence rate;Alcohols;Appointment;Area;behavior change;Behavioral Mechanisms;Benchmarking;Biochemical;Buprenorphine;career development;CCL4 gene;cost efficient;Country;craving;Development;Development Plans;Dose;Dropout;Drug Screening;effective therapy;Effectiveness;efficacy evaluation;eligible participant;Epidemic;Ethics;Ethnic Origin;Fostering;Goals;improved;improved outcome;Individual;innovation;Intervention;intervention effect;intervention program;Literature;medication compliance;medication for opioid use disorder;medication nonadherence;meetings;Mentors;Mentorship;Methadone;Methodology;Methods;mHealth;mhealth interventions;mindfulness;mindfulness intervention;Modeling;multilevel analysis;National Institute of Drug Abuse;New Mexico;Opioid;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;overdose prevention;Participant;patient oriented research;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Placebos;Policies;programs;psychologic;psychosocial;Public Health;Questionnaires;Race;randomized, clinical trials;recruit;Research;research and development;Research Ethics;Research Personnel;research study;response;retention rate;Risk;satisfaction;Self Efficacy;sex as a biological variable;skills;Strategic Planning;Stress;substance use;Substance Use Disorder;synthetic opioid;Text Messaging;therapy design;Time;Training;treatment comparison;Treatment outcome;United States;Universities;Urine;user centered design;Visit;waiver;Withdrawal Symptom

PROJECT_TITLE: Integrating Mindfulness and mHealth Approaches for Treating Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Neuroinflammation (inflammation in the brain) causes reductions in cognitive functions like learning and memory during aging, and it increases the risk for Alzheimer’s disease and other neurodegenerative disorders. The purpose of this research project is to determine if a novel pharmacological treatment that specifically inhibits key cellular drivers of neuroinflammation can improve cognitive function during aging, and/or in the context of Alzheimer’s disease-like pathology. This work may help us understand how and why aging increases the risk for Alzheimer’s disease, and it could provide insight on potential therapeutic strategies for inhibiting these events.

PI_NAMEs: LAROCCA, THOMAS  (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: abeta accumulation;Age;Aging;aging brain;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Anti-Inflammatory Agents;APP-PS1;Attention;behavior test;Behavioral;Biodistribution;Bioinformatics;Biological;Brain;brain health;Brain region;Clinical Data;clinical translation;Clinical Trials;Cognitive;cognitive function;cytokine;Data;Data Set;design;Development;DNA;efficacy testing;Event;Experimental Models;experimental study;Family;Formulation;Future;Gene Targeting;Genes;Genetic Transcription;glial activation;Human;human data;human old age (65+);human subject;immune activation;Impaired cognition;improved;in vivo;Inflammasome;Inflammation;Inflammatory;insight;interest;Learning;Link;marenostrin;Measures;Mediator;Memory;memory recognition;Messenger RNA;mitochondrial dysfunction;Modeling;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;neurotoxic;new therapeutic target;NF-kappa B;novel;novel strategies;nucleic acid-based therapeutics;old mice;Pathologic;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;Play;preclinical study;Prevention;Process;Production;Proteins;Reporting;Research;Research Priority;Research Project Grants;Role;screening;Series;Signal Transduction;small molecule;tau Proteins;Tauopathies;Testing;Therapeutic;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;translational potential;Translational Repression;Wild Type Mouse;Work

PROJECT_TITLE: A novel approach for targeting neuroinflammation in brain aging and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This renewal application for a PRIDE Academy: Health AI and Data Science in Cardiovascular and Pulmonary Disease: Application and Bioethics (HARP-BIO) will select junior faculty scholars under- represented in science and medicine and bring them for two consecutive summer academies at the University of Colorado Anschutz Medical Campus. Here, the scholars will be introduced to state-of-the-art multiomics approaches to study the impact of ancestry and gender on cardiovascular and pulmonary diseases as well as how biases in coding can influence artificial intelligence and machine learning outputs and contribute to health disparities. By examining biases in coding in artificial intelligence and machine learning we will generate fundamental information regarding these technologies and how to apply them ethically and equitably. Scholars will be mentored by experts in personalized medicine and bioethics as well as experts in cardiovascular and pulmonary diseases and will participate in career development activities including social science approaches to ensure scholars' long-term academic persistence. Our overall goal is to create a workforce of pulmonary and cardiovascular researchers who are as diverse as the communities they serve.

PI_NAMEs: DECAMP, MATTHEW WAYNE;FLORES, SONIA CASTRO (contact);YANG, IVANA V

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Academy;Address;Algorithms;Area;Artificial Intelligence;Asthma;Automation;Behavioral;Bioethics;Bioinformatics;biomedical informatics;Capital;Cardiology;Cardiovascular Diseases;Cardiovascular system;career development;Classification;clinical care;clinical database;Code;Collaborations;Colorado;Communities;Community of Practice;Complex;computer program;Computers;cost effectiveness;Critical Care;Darkness;Data;Data Analyses;Data Analytics;data privacy;Data Science;Data Set;Databases;Disease;Disparity;Economics;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Equity;Ethical Issues;Ethics;Evaluation;Extramural Activities;Face;face skin;Faculty;faculty mentor;Failure;Funding;Gender;Generations;Genetic;Genetic Databases;genomic data;Genomics;Goals;Grant;hands on instruction;Health;health disparity;Humanities;individualized medicine;Informatics;Infrastructure;Institution;Instruction;instrument;interest;Lead;Lung;Lung Diseases;Machine Learning;Manuscripts;Measures;Medical;Medicine;member;Mentors;metabolomics;Minority Groups;Modeling;multiple omics;National Heart, Lung, and Blood Institute;Output;Peer Review;personalized medicine;Physicians;Postdoctoral Fellow;Precision Health;precision medicine;Process;programs;Proteomics;Publications;Pulmonary function tests;Pulmonology;Race;recruit;Renal function;Research;Research Personnel;Research Project Grants;Resources;Rights;Risk;Science;Scientist;Shapes;social;Social Sciences;Societies;Student Persistence;Study Section;success;Talents;Techniques;Technology;Testing;theories;tool development;Training;transcriptomics;Transplantation;Trust;Underrepresented Populations;Universities;wearable device;Woman;World Health Organization;Writing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE The loss of cognitive ability in aging and Alzheimer’s disease (AD) is highly variable between individuals as they age, and mechanisms that underlie the heterogeneous aspect of cognitive function have not been investigated. In this application we address whether cell-specific metabolic deficits predict heterogeneity in cognitive function with age. These studies are essential to understanding the molecular mechanisms that can potentially be leveraged to treat cognitive dysfunction with age and in AD.

PI_NAMEs: LOGAN, SREEMATHI  (contact)

PROJECT_TERMS: Ablation;Address;Age;age related decline;age stratification;Age-associated memory impairment;aged;Aging;aging hippocampus;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;animal old age;Antioxidants;APP-PS1;Assessment tool;Astrocytes;astrogliosis;Behavioral;Biological Assay;Cells;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive function;cognitive performance;cognitive testing;Data;Dementia;Disease;Down-Regulation;Electron Transport;Endosomes;Epilepsy;experimental study;FRAP1 gene;Future;Genes;Genetic;Genetic Transcription;Genus Hippocampus;Glial Fibrillary Acidic Protein;Health;healthy aging;Heterogeneity;Hippocampus;Home;Human;human model;Impaired cognition;Impairment;improved;Individual;Inflammation;Inflammatory;Injections;insight;interest;Intervention;Investigation;Knowledge;Label;Link;Measures;Mediating;Mediator;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Molecular Analysis;Molecular Probes;mouse model;Mus;neuroinflammation;old mice;overexpression;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Parkin;Pathway interactions;PINK1 gene;preservation;Process;promoter;protein degradation;Protein Structure Initiative;Proteins;proteostasis;Publishing;Resolution;response;Role;Sampling;single-cell RNA sequencing;SOD2 gene;spatial memory;Spirometry;Subgroup;Synapses;targeted treatment;Testing;Therapeutic Intervention;trafficking;transcriptomics

PROJECT_TITLE: Metabolic determinants of reactive astrogliosis and cognitive heterogeneity in aging

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Childhood Injury;Clinical Research;Data Science;Dissemination and Implementation Research;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

PHR: Acute respiratory failure is common in children and can cause death if clinicians do not support a child’s breathing correctly. This project will develop tools based on machine learning and mathematical models to help clinicians decide how best to support a child’s breathing. This K24 award will support the applicant to increase his available time and effort to mentor junior investigators and to conduct patient-oriented research using informatics and data science methods.

PI_NAMEs: BENNETT, TELLEN  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acceleration;Acute respiratory failure;Address;Adult;Ambulatory Care;Bacteremia;Bacterial Infections;Biological Models;biomedical informatics;Blood;Breathing;Carbon Dioxide;career;career development;Caring;Cause of Death;Child;Childhood;Childhood Injury;Clinical;Clinical Data;clinical decision support;Clinical Informatics;Clinical Psychology;Clinical Sciences;Clinical Trials;Collaborations;Colorado;COVID-19;Critically ill children;Data;Data Science;Data Scientist;Decision Making;design;Development;Development Plans;dynamic system;Education;Electronic Health Record;Endocrinology;Environment;Etiology;Evaluation;Excision;experience;Future;Goals;Grant;Heart failure;Hematology;implementation tool;improved;improved outcome;Individual;Informatics;inpatient service;Intensive Care;Intervention;Intubation;investigator training;Lead;Leadership;Link;lung injury;Machine Learning;machine learning model;Malignant - descriptor;Malignant neoplasm of thyroid;mathematical model;Mechanical ventilation;medical schools;Medicine;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel strategies;Operative Surgical Procedures;Outcome;patient oriented;patient oriented research;Patient-Focused Outcomes;Patients;Pharmacy facility;Phenotype;Physicians;physiologic model;Physiology;Postpartum Depression;Predictive Analytics;predictive modeling;Procedures;programs;prospective;Prospective, cohort study;Registries;Research;research and development;Research Personnel;Research Support;Research Training;Resources;respiratory;Respiratory System;Risk;Role;Scientist;Sedation procedure;Sepsis;signal processing;skills;statistical and machine learning;Structure;support tools;Testing;Time;tool;Training;Training Programs;Translating;Translational Research;Translations;Traumatic Brain Injury;Tube;United States National Institutes of Health;Universities;Ventilator;Ventilator-induced lung injury;Work

PROJECT_TITLE: Mentoring and Patient-Oriented Research in Clinical Informatics and Data Science

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Narrative Statement To date, few clinical trials for tauopathy have specifically targeted pathological tau, yet neurofibrillary tangles are the diagnostic neuropathological hallmark of AD and CTE that is most closely associated with cognitive decline. To help fill this gap, we propose to develop novel neuroprotective strategies that target pathological tau in AD and CTE related dementia disorders. Specifically, we propose to develop therapeutic ideas for targeting pathological tau. These novel agents will provide a proof-of-concept demonstration that inhibiting targeting pathological tau deposition can improve neurodegenerative outcomes.

PI_NAMEs: KRAEMER, BRIAN C. (contact)

PROJECT_TERMS: age related neurodegeneration;Aging;aging related;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Area;Automobile Driving;Autopsy;Award;Biological Models;Birds;Black race;Brain;Caenorhabditis elegans;calcineurin phosphatase;career;Cell model;Clinical Trials;commercialization;Communication;Complex;Dementia;Deposition;Development;Diagnostic;Direct Costs;Disease;drug discovery;Endoplasmic Reticulum;experience;Foundations;Frontotemporal Lobar Degenerations;Funding;Future;Genes;Goals;Health;Healthcare;high throughput screening;Human;human disease;human tissue;Impaired cognition;improved;indexing;inhibitor;insight;Intervention;Invertebrates;Investigation;Laboratories;loss of function;Mediating;Medical;Microtubule Polymerization;Mission;Modeling;Molecular;Molecular Conformation;Molecular Target;motor disorder;nanobodies;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nature;Nerve Degeneration;neurobehavior;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;neurotoxicity;novel;novel therapeutics;Outcome;Pathologic;Pathology;Pathway interactions;Peer Review;Phase;Phosphorylation;Play;Poly(A)-Binding Proteins;Predisposition;programs;protein aggregation;protein TDP-43;Proteins;Publications;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;RNA;Rodent;Role;Scientist;Services;small molecule;Study Section;System;tau Proteins;tau-1;Tauopathies;Technology;Therapeutic;therapeutic development;Tissue Sample;Toxic effect;Transgenic Organisms;translational medicine;Translational Research;United States National Academy of Sciences;Veterans;Washington;Work;working group;XBP1 gene


PHR: The most common cause of hospitalization for Veterans, acute cardiovascular disease, commonly injures the kidneys, and can cause long-term chronic kidney disease. Chronic kidney disease in turn is closely associated with worsening of cardiovascular disease, particularly high blood pressure. The current study will evaluate the development of new high blood pressure in a model of acute cardiovascular disease, which is very similar to the human clinical condition. We propose a mechanism in which a factor released by the heart changes kidney function, causing high blood pressure; this mechanism is potentially interruptible with drug therapy. Successful completion of this project is therefore expected to evaluate a new potential means for the heart and kidney to interact in causing disease which is highly relevant to Veteran and public health.

PI_NAMEs: HUTCHENS, MICHAEL P (contact)

PROJECT_TERMS: ACE2;Acute;Admission activity;Animals;apical membrane;Architecture;awake;Blood Pressure;blood pressure regulation;Cardiac;cardiogenesis;Cardiopulmonary Resuscitation;Cardiorenal syndrome;Cardiovascular Diseases;Cell Differentiation process;Cell surface;Cells;Chronic;Chronic Kidney Failure;Clinical;comorbidity;Critical Pathways;Data;Development;Differentiation Antigens;Disease;early onset;Endocrine;Endocytosis;Epithelial Cells;Epithelium;experimental study;Exposure to;Extracellular Matrix;Gene Deletion;Genes;Genetic Transcription;Goals;Health;Heart;Heart Arrest;Heart Diseases;Heart Injuries;Histology;Hospitalization;Human;Hypertension;hypertensive;Hypertrophy;Immunofluorescence Immunologic;improved;In Vitro;in vivo;inflammatory milieu;Injections;Inpatients;Interruption;Intervention;Investigation;Kidney;Kidney Diseases;kidney fibrosis;kidney vascular structure;knock-down;Laboratories;LDL-Receptor Related Protein 2;Left Ventricular Hypertrophy;long-term sequelae;Mediating;Mediator;Medical center;Membrane;Methods;Modeling;mouse model;Mus;Muscle;Muscle Cells;Myocardial;myogenesis;Nephrosclerosis;novel;Outcome;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Plasma;prevent;Proteins;Proximal Kidney Tubules;Public Health;Publishing;Recombinants;Recovery;Regulation;release factor;renal epithelium;Renal function;Renin-Angiotensin System;Repression;Research;response;Role;Signal Transduction;small hairpin RNA;Systemic hypertension;Testing;Therapeutic Intervention;Thick;Transcript;Transcription Coactivator;Transcriptional Regulation;Transforming Growth Factor beta;translational model;translational potential;Translational Research;Tubular formation;United States Department of Veterans Affairs;uptake;Urine;Ventricular Remodeling;Veterans;Veterans Health Administration;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Myocyte-to-kidney Signaling in Cardiorenal Nephrosclerosis and Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Lung;Mental Health;Mental Illness

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Preliminary data by our group suggests that escitalopram decreases asthma exacerbations and improves asthma control among depressed people with asthma. Therefore, a two-phase developmental clinical trial is proposed examining escitalopram vs. placebo in a more general sample of people with frequent asthma exacerbations.

PI_NAMEs: BROWN, E SHERWOOD  (contact);KHAN, DAVID A

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Adult;Adult asthma;African American population;Age;Agonist;Animal Model;anti-depressive agents;Anti-Inflammatory Agents;Antiinflammatory Effect;Anxiety;anxiety symptoms;Asthma;asthma exacerbation;asthmatic patient;Attenuated;Bronchoalveolar Lavage Fluid;CD3 Antigens;Cells;Childhood Asthma;Citalopram;Clinic;Clinical Data;Clinical Trials;Collaborations;Computerized Medical Record;Data;Death Rate;Depressed mood;depressive symptoms;Development;Diagnosis;Disease;Dose;double-blind placebo controlled trial;effective therapy;Emotions;eosinophil;Escitalopram;Exclusion;Exhalation;experience;Extrinsic asthma;Fellowship Program;Frequencies;Funding;Genetic Transcription;Glucocorticoid Receptor;Grant;Health;High Prevalence;Hispanic Populations;Hypersensitivity;Immunology;improved;In Vitro;Inflammation;Inhalation;inner city;Interleukin-2;Interleukin-4;Interleukin-6;Lipopolysaccharides;Literature;Lymphocyte;Macrophage;Major Depressive Disorder;Mediating;Mediator;men;Mental Depression;Minority;monocyte;Moods;Muscarinic Antagonists;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;negative emotional state;neutrophil;Nitric Oxide;Oral;Outcome;Outcome Measure;Outpatients;Patients;Persons;Phase;Placebos;Poverty;predicting response;Prediction of Response to Therapy;Prednisone;Prevalence;primary outcome;Process;professor;programs;Property;Psyche structure;psychologic;Public Health;Pulmonary Inflammation;Quality of life;Questionnaires;Randomized;randomized placebo controlled trial;Recording of previous events;Reporting;Research Personnel;response;Sampling;Secondary to;Selective Serotonin Reuptake Inhibitor;Serum;Severities;sex;SF-36;Site;Statistical Data Interpretation;Steroids;subclinical depression;Testing;Texas;TNF gene;treatment group;United States National Institutes of Health;Woman

PROJECT_TITLE: A Selective Serotonin Reuptake Inhibitor for Asthma Patients with Frequent Exacerbations

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (OA)]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Relevance HIV-1 establishes reservoirs that resist drug and immunological treatments, indicating that basic studies are needed to understand how to target these sites. We have described an SIV model in which a mutation in the envelope cytoplasmic tail leads to cellular immune control but with persistent reservoirs. Our proposal takes advantage of unique attributes of this model to assess novel interventions that can reveal vulnerabilities in the reservoir and inform targeted approaches to eliminate HIV-1 reservoirs in humans.

PI_NAMEs: HOXIE, JAMES A (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: acute infection;Address;Amino Acids;Anatomy;Animal Model;Animals;Anti-viral Therapy;Antibodies;antibody engineering;antibody mimetics;antiretroviral therapy;Binding;Biological Assay;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Clonal Expansion;Complement;Control Animal;Cytoplasmic Tail;decay acceleration;DNA;experimental study;Future;Genetic Transcription;Goals;HIV;HIV Infections;HIV-1;Human;humanized mouse;Immune;immune activation;Immune response;immunological intervention;Immunologics;Individual;Infection;integration site;Intervention;Length;Longevity;Lymphoid;Lymphoid Tissue;Macaca;Macrophage;Modeling;Mutation;neutralizing antibody;nonhuman primate;novel;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Plasma;Predisposition;prevent;Production;Proliferating;Proviruses;Research;response;Signal Transduction;simian human immunodeficiency virus;Site;SIV;success;synergism;T-Lymphocyte;Technology;Testing;Time;Tissues;trafficking;Viral;Viral Genome;viral rebound;Viral reservoir;viral RNA;Viremia;Virus;Virus Integration;Virus Latency

PROJECT_TITLE: Targeted interventions to reduce or eliminate the SIV reservoir in a novel model of elite control

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The goal of this project is to make magnetic resonance spectroscopy (MRS) more reliable by correcting for subject motion in real-time and by automating MRS scans. With improved reliability and ease of use, the full potential of brain and spinal cord MRS will be widely available for upcoming clinical studies and gene therapy trials.

PI_NAMEs: DEELCHAND, DINESH KUMAR (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Adrenoleukodystrophy;Adult;Age;aging brain;anatomic imaging;Automation;Biochemistry;Brain;Brain Chemistry;Calibration;Central Nervous System Diseases;Child;Clinical;Clinical Trials;Collaborations;Communities;Consensus;Data;data acquisition;Data Analyses;Devices;Disease;Elderly;experience;Friedreich Ataxia;Funding;gene therapy;gene therapy clinical study;Gene therapy trial;Goals;healthy volunteer;Human;human subject;Image;image registration;improved;Institution;International;Life;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Manufacturer;Measurement;Metabolism;Methodology;Methods;Morphologic artifacts;Motion;Movement;Movement Disorders;Mucopolysaccharidosis I;Multi-Institutional Clinical Trial;Nervous System Disorder;Noise;Optics;Patients;pediatric department;Performance;Physiologic pulse;Play;Population;Positioning Attribute;prospective;Protocols documentation;Protons;Publishing;Reporting;Reproducibility;Research;Resolution;Role;Scanning;Signal Transduction;Site;Slice;spectroscopic data;spectroscopic imaging;Spinal Cord;Standardization;Techniques;Time;Translating;Vertebral column;Water

PROJECT_TITLE: Fully Automated Motion-corrected MR Spectroscopy in Human Brain and Spinal Cord

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: It is estimated that diabetes affect 25% of the VA patients and with more than 70% of patients in VA facilities being overweight or obese, type 2 diabetes becoming a major health concern. Diarrhea is one of the most common gastrointestinal complications in diabetes, and yet understanding and treatment for diabetic diarrhea are lacking. The proposed study is aimed at understanding the underlying cause of diarrhea in type 2 diabetes where diarrhea is often associated with medications. We will explore the role of a sodium-hydrogen exchange in the intestine as a major cause of diabetic diarrhea and perform a pre-clinical study to test the efficacy of biological agents for the treatment of diarrhea.

PI_NAMEs: YUN, CHANGHYON CHRIS (contact)

PROJECT_TERMS: absorption;Adenosine Monophosphate;Adverse effects;Affect;Anti-diabetic Drugs;Bicarbonates;Bifidobacterium;Bile Acids;Biological Products;Butyrates;Caring;Cell model;clinically relevant;clinically significant;Colon;Complications of Diabetes Mellitus;Coupled;Data;db/db mouse;Diabetes Mellitus;diabetic;diabetic patient;Diarrhea;Drug Prescriptions;efficacy testing;Electrolytes;Epithelial Cells;Exocytosis;experience;Experimental Models;FRAP1 gene;Freedom;Functional disorder;gastrointestinal;Gastrointestinal Motility;Gastrointestinal Transit;Genomics;glycemic control;Goals;Growth;Health;Health Services;Human;humanized mouse;Hydrogen;improved;In Vitro;in vivo;Incidence;Inflammatory;intestinal epithelium;Intestines;Ions;Link;Liquid substance;lysophosphatidic acid;Malabsorption Syndromes;Mediating;Mediator;Messenger RNA;Metformin;Military Personnel;mouse model;Mus;Nature;new therapeutic target;non-genomic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;operation;Overweight;Patients;Pharmaceutical Preparations;pharmacologic;Phospholipids;Phosphotransferases;preclinical study;Preclinical Testing;prevent;PRKCA gene;Probiotics;protein protein interaction;Refractory;Regulation;Reporting;Research Design;Role;Scheme;service member;Severities;Signal Pathway;Sodium;Soldier;targeted treatment;Testing;Time;Tissues;Type 2 diabetic;type I diabetic;ubiquitin-protein ligase;Ubiquitination;United States;United States Department of Veterans Affairs;Veterans;Volatile Fatty Acids

PROJECT_TITLE: Role of Na+/H+ exchanger in diabetic diarrhea


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Atherosclerosis is the leading cause of death and disability in the Western world, however, the mechanisms underlying atherosclerosis are complex and remain obscure despite intense research in this area. I propose to establish for the first time the cause-and-effect relationship between the enzyme lysyl oxidase and atherosclerosis using unique animal models developed by our team. This study could provide new therapeutic treatments that reduce the risk of developing cardiovascular diseases.

PI_NAMEs: STOYELL-CONTI, FILIPE FERNANDES (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adult;Affect;American;amine oxidase;Animal Model;Animals;Area;Arterial Occlusive Diseases;Arteries;atherogenesis;Atherosclerosis;Award;Belief;Bioinformatics;Biology;Blood Vessels;Breeding;Cardiovascular Diseases;Career Mobility;Cause of Death;cell dedifferentiation;cell motility;Cell Nucleus;Cells;Cellular biology;cerebrovascular;Collagen;Complex;Confocal Microscopy;Copper;Coronary Arteriosclerosis;Critical Thinking;crosslink;Data Analyses;Deposition;Development;disability;Disease;Doctor of Philosophy;effective therapy;Elastin;Enzymes;Extracellular Matrix;Fellowship;Foam Cells;gain of function;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Goals;Grant;healing;Histology;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Inflammation;Knock-in Mouse;Knowledge;Label;Laboratories;lentivirally transduced;Lesion;Lipids;Location;loss of function;Mentors;Microdissection;migration;Minority;Molecular;Molecular Biology;Molecular Biology Techniques;Molecular Cloning;monomer;mouse model;Mus;Mutagenesis;novel;novel therapeutics;overexpression;Peripheral arterial disease;Phenotype;prevent;Principal Investigator;Protein-Lysine 6-Oxidase;Research;Risk;Risk Reduction;Role;Rupture;skills;Smooth Muscle Myocytes;Systems Biology;Tamoxifen;Testing;thrombotic;Time;Training;transcriptome sequencing;transcriptomics;Transgenic Mice;ultrasound microscopy;Western World

PROJECT_TITLE: The importance of Lysyl Oxidase in Atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F10C-A(20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative A wide range of cognitive functions depend on brain mechanisms that support decision-making. Restoring these mechanisms will likely play an essential role in future treatments of brain disorders affecting cognition. The project will elucidate the neural mechanisms underlying an encephalographic signature of complex decisions made by normal humans by establishing its underpinnings at the level of neural circuits.

PI_NAMEs: BICKEL, STEPHAN ;KELLY, SIMON ;O'CONNELL, REDMOND ;SHADLEN, MICHAEL NEIL (contact);WONG-LIN, KONGFATT

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Uncovering the neural architecture underlying decisions abstracted from movements

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Stroke

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Atrial fibrillation (AF) is the most common arrhythmia, affecting 33.5 million people globally with a growing prevalence. AF is associated with significant morbidity and mortality, including 20% of all strokes, 33% of hospitalizations related to cardiac arrhythmias, and a two-fold increase in risk of death. To reduce AF-associated risks such as stroke, it is important to be able to diagnose AF early in the AF trajectory when it is asymptomatic and paroxysmal in order to initiate effective stroke prevention interventions including anticoagulation. We propose an integrated data and algorithm strategy as well as a prospective study to fully exploit and validate the power of deep neural networks, interpretable survival models, and Big Data to achieve both high sensitivity and precision in using photoplethysmography (PPG) to detect AF and to use EHR data to identify patients with high risk of AF post stroke to benefit from continuous AF monitoring.

PI_NAMEs: HU, XIAO  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Address;Adhesives;Adult;Affect;Aging;Algorithms;Anticoagulation;Apple;Arrhythmia;Atrial Fibrillation;Attention;Benchmarking;Big Data;Blood Volume;Cardiac;Classification;Complement;convolutional neural network;cost;cost effective;Data;data integration;Data Set;deep neural network;design;Detection;Diagnosis;Diagnostic;discrete time;Effectiveness;Electrocardiogram;Event;Fingers;fitbit;follow-up;Goals;Heart;high risk;Hospitalization;improved;Inferior;Inpatients;Knowledge;Label;Learning;Link;loss of function;Machine Learning;Measures;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;neural network architecture;novel;Output;Patients;Pattern;Performance;Persons;Photoplethysmography;Physiological;Plethysmography;Population;post stroke;pre-trained model;Predictive Value;Prevalence;preventive intervention;Probability;prospective;Prospective Studies;recurrent neural network;Reporting;repository;Risk;Screening procedure;sensor;Signal Transduction;Sinus;Stroke;stroke patient;Stroke prevention;Testing;Time;tool;Training;wearable device;Weight;Wrist

PROJECT_TITLE: Novel Algorithm and Data Strategies to detect and Predict atrial fibrillation for post-stroke patients (NADSP)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Kidney Disease;Patient Safety

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Over 726,000 individuals in the U.S. have end-stage renal disease (ESRD) with about 87% of patients on the life-sustaining treatment of dialysis at over 6,000 dialysis facilities across U.S. The proposal involves developing new methods for studying time-dynamic effects of patient-, facility- and region-level factors (across U.S.) of hospitalization and mortality risk among dialysis patients, a cohort with frequent hospitalizations and very high mortality rates. The overarching goal is to provide the knowledge base for improving patient care by identifying modifiable multilevel risk factors and time periods of elevated risks after transition to dialysis.

PI_NAMEs: KURUM, ESRA ;NGUYEN, DANH V;SENTURK, DAMLA  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Address;adverse outcome;Anemia;Blood Vessels;bone;Caring;Characteristics;Chronic;Chronic Kidney Failure;Clinical;cohort;comorbidity;comparative;Comparative Study;Complex;Data;Data Linkages;data structure;Databases;Death Rate;Development;Dialysis patients;Dialysis procedure;End stage renal failure;experience;flexibility;Geographic Locations;Goals;Grant;Heart failure;high dimensionality;hospital readmission;Hospitalization;hospitalization rates;Hot Spot;human old age (65+);improved;Individual;Information Systems;innovation;insight;Joints;Kidney;knowledge base;large datasets;Life;Link;Malignant Neoplasms;Maps;Medicare;Methodology;Methods;Minerals;Modeling;modifiable risk;Monitor;mortality;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;Nurses;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Population;Positioning Attribute;Procedures;prospective;Public Health;readmission rates;Renal function;Research;Research Design;Residual state;Risk;Risk Factors;simulation;spatiotemporal;Structure;survival outcome;Survival Rate;Time;Time Factors;treatment strategy;United States;United States National Institutes of Health;Validation;validation studies;Variant;Work

PROJECT_TITLE: Multilevel Time-Dynamic Modeling of Hospitalization and Survival in Patients on Dialysis

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Continued acceleration of the pace of discovery has increased the challenge of bringing the fruits of scientific discoveries to our community. The NYU-H+H CTSI supports more rapid translation of scientific advances into medical breakthroughs by partnering NYU's scientific and educational resources with both the largest metropolitan healthcare system (H+H) in the US and our remarkably diverse community. Project Narrative Page 303

PI_NAMEs: BREDELLA, MIRIAM ANTOINETTE;CRONSTEIN, BRUCE NEIL (contact);HOCHMAN, JUDITH S

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Acceleration;Address;Adopted;Agreement;Award;behavioral health;Caring;Catalogs;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communities;community engagement;community organizations;community partners;Data;data management;data sharing;Dedications;design;Development;Device or Instrument Development;digital;Discipline;Drug Delivery Systems;drug development;education resources;Effectiveness;electronic health data;Electronic Health Record;Ensure;Environment;epidemiology study;Ethnic Population;evidence base;Fostering;Fruit;Funding;Good Clinical Practice;Health;health care delivery;health difference;health disparity;Healthcare Systems;high dimensionality;Hospitals;improved;Informatics;Infrastructure;innovation;Institution;interest;Licensing;Life;life span;Medical;medical schools;member;Methodology;Methods;metropolitan;Mission;Modeling;Multicenter Trials;multidisciplinary;multiple omics;Municipalities;National Center for Advancing Translational Sciences;New York;New York City;next generation;novel;Outcome;patient oriented;Patients;Phase;Population;population health;Population Heterogeneity;Privatization;Procedures;Process;programs;protocol violation;Provider;public-private partnership;Publications;racial diversity;racial population;Recording of previous events;recruit;Reproducibility;Research;Research Institute;Research Personnel;Research Support;Resources;Safety;Schools;Science;Scientific Advances and Accomplishments;Services;Site;skills;Special Population;Special Populations Research;Speed;Technology;Training;Training and Education;training opportunity;Training Programs;Training Support;Translating;translational pipeline;Translational Research;translational scientist;Translations;United States;United States National Library of Medicine;Universities;Validation;Vision;wearable device;Workforce Development


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Modified Public Health Relevance Section Our primary objective of this project is to determine the molecular mechanism of ZNF804A controlling protein translation in neocortical development. By using integrative and sophisticated genomic/ proteomic approaches, we will elucidate the functional gene-gene interaction of ZNF804A with other developmental genes, which may alter the brain development and consequently contribute to changes in brain structures.

PI_NAMEs: MAO, YINGWEI  (contact);SHI, YONGSHENG

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adolescence;Adult;Affect;Age;autism spectrum disorder;Behavior;Behavioral;Binding;Binding Sites;Biological Assay;Bipolar Disorder;Brain;Brain Diseases;Cells;crosslink;crosslinking and immunoprecipitation sequencing;Defect;Development;Developmental Delay Disorders;Developmental Gene;Disease;DNA-Binding Proteins;Etiology;Functional disorder;gene interaction;Genes;Genetic;genetic association;genetic predictors;Genetic Risk;Genomics;high throughput analysis;Human;Immunoprecipitation;in vivo;innovation;insight;Knockout Mice;Knowledge;Life;Maps;Measures;Mediating;Medical;Mental disorders;Messenger RNA;migration;Molecular;mosaic analysis;Mus;neocortical;nerve stem cell;Nervous System;Nervous System Disorder;neurodevelopment;neurogenesis;neurogranin;neuroimaging;neuronal circuitry;Neurons;Neuropsychology;novel therapeutics;Pathologic;Patients;Physiological;Play;Population;Production;progenitor;Protein Biosynthesis;Proteins;Proteomics;public health relevance;Publishing;Puromycin;Regulation;Reporting;Research Proposals;Risk Factors;risk variant;RNA-Binding Proteins;Role;Schizophrenia;stem cell proliferation;Structure;System;Techniques;Testing;theories;Transcript;Translational Regulation;Translations;Variant;Wild Type Mouse;Zinc Fingers

PROJECT_TITLE: Translational control in neurogenesis by ZNF804A

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Brain Disorders;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PROJECT NARRATIVE Major depression (MD) is a leading cause of disability worldwide, arises from the action and interaction between genetic and environmental factors, and is often comorbid with other psychiatric and medical conditions. Although recent progress has yielded modest insight into the genetic architecture of MD, most studies have been in European ancestry populations, seriously limiting our knowledge of human genomic variation, disease etiology, and precision medicine efforts. Here, we propose cross-population genetic studies of MD to advance our understanding of the genetic architecture in all populations and ensure that genetic research is broadly applicable.

PI_NAMEs: PETERSON, ROSEANN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;African;Anxiety Disorders;Architecture;Asian;biobank;Catalogs;causal model;causal variant;clinical phenotype;clinically relevant;cohort;Collaborations;comorbidity;Data Collection;data harmonization;Data Set;Diagnosis;disability;Disease;empowerment;Ensure;Environment;Environmental Risk Factor;Etiology;European;European ancestry;Genes;Genetic;genetic approach;genetic architecture;Genetic Population Study;Genetic Research;Genetic Risk;Genetic study;genetic variant;genome wide association study;genome-wide;genomic variation;Genomics;Genotype;Goals;Heart Diseases;Human;improved;insight;Knowledge;Latino;Lead;Major Depressive Disorder;Maps;Medical;men;Mendelian randomization;Mental Depression;Mental disorders;Meta-Analysis;Methods;Modeling;National Institute of Mental Health;non-genomic;Obesity;Persons;Phase;Phenotype;polygenic risk score;Population;Population Analysis;Population Heterogeneity;Population Study;precision medicine;Prevalence;Prevention;Process;psychogenetics;Research;Research Personnel;Resolution;Resources;Risk;Risk Factors;Role;Sampling;Sex Differences;Strategic Planning;study population;substance use;Syndrome;Testing;trait;Underrepresented Populations;Woman;Work;working group

PROJECT_TITLE: Cross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through Diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(03)]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Metabolism is the process by which food is converted into energy and the molecular building blocks necessary for life. It is highly dynamic and changes rapidly with different conditions, for example after a large meal or vigorous exercise. We can measure a great number of metabolites in chemical extracts or biofluids, but there are few methods to measure metabolites in living systems. This project is to develop a better method to measure metabolism in a living microorganism in different conditions.

PI_NAMEs: EDISON, ARTHUR S (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Platform for in vivo Metabolism

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Metastatic disease is resistant to current therapies and remains the primary cause of cancer related death. We identified that specific distant organs away from the primary tumor can create the “pre-metastatic niches” for future metastasis initiation by recruiting platelets to vessel wall which will in turn support circulating tumor cell to slowdown and attach on the vessel wall, thus affecting physical transport of cancer cells. Objective of this proposal is to elucidate the both biological and physical roles of the pre-metastatic niche for initiation of metastasis and we anticipate that the proposed research will bring a strong scientific framework for elucidate unknown role of platelets for initiating metastasis and rational prevention of metastasis.

PI_NAMEs: KOJIC, MILOS ;LEONARD, FRANSISCA ;LIU, XUEWU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Affect;Aspirin;Biological;Biological Factors;biophysical properties;Biophysics;Blood capillaries;Blood flow;Blood Flow Velocity;Blood Platelets;Blood Vessels;cancer cell;Cancer Etiology;Cancer Patient;Cell Communication;Cell Line;Cessation of life;Characteristics;Circulation;Clinic;Computer Models;Data;Deposition;Development;Disease;Distant;Event;Evolution;Future;Image;imaging study;Immobilization;Immobilized Cells;in silico;In Vitro;in vivo;in vivo imaging;innovation;intravital microscopy;Label;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;metastasis prevention;Microfluidics;Modeling;Modification;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;Nonmetastatic;novel;Oncology;Organ;Pathology;Perfusion;Phenotype;Physics;platelet function;Prevention;Primary Neoplasm;Probability;Process;quantitative imaging;Reagent;recruit;Reporting;Research;Resistance;response;Risk;Role;Site;System;Testing;Time;tumor;Tumor Cell Invasion;tumor growth

PROJECT_TITLE: Biophysical roles of pre-metastatic niche evolution on transport of circulating tumor cells


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: CLARK ATLANTA UNIVERSITY

PHR: PROJECT NARRATIVE The biomedical training program, CAU G-RISE, is focused on training highly motivated predoctoral students in biomedical sciences with special emphasis on training activities to support success. Trainees will participated in activities that fosters development of skillsets that are transferable to the diverse career opportunities in the biomedical workforce. The proposed program will mentor trainees and faculty to achieve scientific goals of significance, and make long-term contributions to the biomedical research enterprise.

PI_NAMEs: INGRAM, CONRAD ;POWELL, JOANN B. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: CAU G-RISE

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Depression;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Depression and cognitive problems are extremely common in people with HIV and may have a shared cause. Since iron is needed for balanced production of chemicals in the brain that are linked to mood and cognition, changes in iron due to HIV infection can upset this delicate balance. This study will determine whether changes in iron, and in genes that control iron metabolism, can predict development of depression and cognitive problems in people with HIV, leading to new treatment strategies.

PI_NAMEs: KALLIANPUR, ASHA R (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Age;age effect;Aging;Animals;Anti-Retroviral Agents;antiretroviral therapy;bioinformatics network;Biological Factors;Biological Markers;Brain;Cerebrospinal Fluid;Chemicals;Clinical;Cognition;Cognitive;cohort;Cohort Studies;comorbidity;Data Set;Depressed mood;Development;Diagnostic;Disease;Disease Management;Dopamine;Energy Metabolism;Epidemiology;Equilibrium;experience;follow-up;Frequencies;gene interaction;gene network;General Population;Genes;Genetic;Genetic Predisposition to Disease;genome wide association study;genome-wide;genomic data;Genomics;glial activation;High Prevalence;HIV;HIV Infections;HIV Seropositivity;Homeostasis;Homovanillic Acid;Human;Immune;Impaired cognition;In Vitro;indexing;Individual;Inflammation;inhibitor;Integrase;Intervention;Iron;iron metabolism;Joints;knock-down;Kynurenine;life span;Link;Longitudinal Studies;Major Depressive Disorder;Measures;Mediating;medication compliance;medication nonadherence;men;Mental Depression;Metabolic;Metabolism;Microglia;Mitochondria;Modeling;monoamine;Moods;mortality;myelination;neural circuit;neuroAIDS;neurobiological mechanism;Neurocognitive Deficit;neurogenesis;neuroinflammation;Neurons;neuropsychiatric disorder;neuropsychiatry;neurotoxic;neurotransmitter metabolism;Neurotransmitters;novel;novel therapeutic intervention;older adult;older women;Participant;Pathway Analysis;Pathway interactions;Persons;Pharmaceutical Preparations;precision medicine;Predisposition;Production;prospective;Proteins;Quality of life;Quantitative Trait Loci;Recording of previous events;Regulator Genes;Research;Risk;Role;Serotonin;Serum;sex;Sex Differences;Substance abuse problem;Testing;Woman;Work

PROJECT_TITLE: Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and Genetics

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome

ORG_DEPT: DENTISTRY

PHR: High-throughput genomic technologies are increasingly being used in dental, oral and craniofacial research from discovery to clinical decision making, raising an enormous need for quantitative genomics expertise. The proposed “Bruins In Genomics for Dental, Oral and Craniofacial Research Training Program (BIG DOC)” aims to address this need by providing a mentored summer didactic and research experience to 20 undergraduate researchers from diverse and underrepresented minority backgrounds.

PI_NAMEs: HOFFMANN, ALEXANDER ;PAPP, JEANETTE CHRISTINE;PELLEGRINI, MATTEO ;WONG, DAVID T (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Area;Big Data;Biological;Biological Sciences;Biology;Biomedical Research;career;career development;Chromosome Mapping;clinical care;clinical decision-making;clinical practice;cohort;Communities;craniofacial;Data;Data Analyses;Data Science;deaf;Dedications;Dental;Dentistry;Dentists;Development;Diagnosis;disability;disadvantaged background;Disease;Doctor of Philosophy;education research;Educational workshop;Ethnic Population;experience;Faculty;Funding;Future;Generations;Genome;genome sciences;Genomics;Goals;hands on research;Health;health disparity;Health Sciences;high throughput screening;Historically Black Colleges and Universities;Human Biology;Infrastructure;Learning;Medical;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;mid-career faculty;Mining;Minority-Serving Institution;National Institute of Dental and Craniofacial Research;next generation;next generation sequence data;next generation sequencing;Oral;Oral health;Participant;Pathology;personalized care;personalized medicine;programs;Public Health;racial population;recruit;Rehabilitation therapy;Research;Research Personnel;Research Priority;Research Project Grants;Research Training;Residencies;Risk;Risk Management;Science;science teacher;Scientist;Sequence Analysis;Series;skills;Societies;student training;Students;summer program;summer research;summer student;Technology;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations

PROJECT_TITLE: Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)