NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: úú PROJECT NARRATIVE Point-of-care diagnostics have shown the potential to transform health care by the real-time screening of disease states and treatment outcomes as needed. Alongside the computational protein design of de novo switches and binders, this proposal aims to develop a new class of reliable, rapid, and inexpensive protein biosensors at point-of-care that generate measurable light or color signals only when mixed with patient samples containing disease biomarkers with a drop of patient specimens. By enabling detection, the proposed projects align with the National Institute of Health’s mission to reduce illness and disability and to advance basic research and medical care.

PI_NAMEs: YEH, HSIEN WEI  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Algorithms;Antibodies;antibody detection;Area;Basic Science;Binding;Binding Proteins;Biological Assay;Biological Markers;Bioluminescence;Biosensor;Body Fluids;Botulinum Toxins;Bypass;Cardiac;career;career development;Caring;Clinic;Clinical;clinically relevant;Collection;Color;Colorimetry;complement system;Consumption;Coupled;Coupling;COVID-19;COVID-19 pandemic;Creativeness;Darkness;design;Detection;Development;Development Plans;Devices;Diagnostic;Diagnostic Reagent;Diagnostic Services;Directed Molecular Evolution;disability;Disease;Drops;Economics;emergency settings;Energy Transfer;Engineering;Enzyme-Linked Immunosorbent Assay;Equilibrium;ERBB2 gene;Event;Fc domain;flu;Future;Gene Order;Goals;health care availability;health care quality;health care service;Health Priorities;Healthcare;Hepatitis B Antibodies;Hepatitis B Virus;Home;Hospitals;Human;improved;Incubated;instrument;interest;Interleukin-6;Light;Luciferases;luminescence;Measurable;Measures;Medical;Mentors;Mentorship;Methods;Mission;Modality;Molecular;Molecular Conformation;molecular diagnostics;Monitor;Monoclonal Antibodies;Names;neutralizing antibody;novel;Oligonucleotide Microarrays;pandemic impact;pathogen;Patients;Peptides;personalized medicine;Phase;point of care;point of care testing;point-of-care diagnostics;precision medicine;protein biomarkers;Protein Engineering;Proteins;Published Comment;ratiometric;receptor;receptor binding;Reporter;Reporting;Research;Research Personnel;Sampling;SARS-CoV-2 antibody;seasonal influenza;sensor;Serology test;Signal Transduction;Specimen;Surface;synergism;System;systemic inflammatory response;Technology;Therapeutic;Thermodynamics;Time;Treatment outcome;Troponin I;tv watching;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: De novo design of a generalizable protein biosensor platform for point-of-care testing

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). We aim to deeply interrogate human brain tissue and an experimental model of human brain cells to better understand the processes that result in abnormally high inflammation in the brain in some individuals that result in an elevated risk for Alzheimer’s disease.

PI_NAMEs: YOUNG-PEARSE, TRACY L (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Address;Adult;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid beta-Protein;Astrocytes;Biology;Brain;brain cell;brain health;brain tissue;CASP1 gene;CD36 gene;cell type;Cells;Coculture Techniques;Cognitive;cohort;conditional knockout;Constitution;CRISPR/Cas technology;cytokine;Data;Detergents;Development;Disease;Disease Progression;Environment;Enzyme-Linked Immunosorbent Assay;Exhibits;Experimental Models;experimental study;Formic Acids;Functional disorder;Genes;genetic risk factor;Genetic study;Genetic Transcription;Genome engineering;genome wide association study;Health;Heterogeneity;Heterozygote;Human;human induced pluripotent stem cells;human model;IL18 gene;Immune;Immune signaling;Impairment;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammasome;Inflammation;Inflammatory;inhibitor;inorganic phosphate;insight;Interleukin-1 beta;Interleukin-13;Knockout Mice;Late Onset Alzheimer Disease;Length;Link;Literature;Lysosomes;Measurement;Medial;Mediating;Membrane;Microglia;Modeling;Molecular;mouse model;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroimmunomodulation;neuroinflammation;Neurons;Pathogenesis;Pathway interactions;Phagocytosis;pharmacologic;phosphoinositide-3,4,5-triphosphate;phosphoinositide-3,4-bisphosphate;Phosphoric Monoester Hydrolases;Play;Prefrontal Cortex;Process;Proteins;Proteomics;Receptor Up-Regulation;receptor upregulation;Regulation;Reporting;response;Risk;RNA;Role;Sampling;scavenger receptor;Senile Plaques;Series;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Stains;Synapses;System;tau Proteins;tau-1;TNF gene;transcriptome sequencing;Transgenic Mice;Up-Regulation;Variant;Visualization;Water;Western Blotting;Work

PROJECT_TITLE: Probing Heterogeneity of Alzheimer's Disease Using iPSCs

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative Osteoarthritis is an enormous and increasing public health problem that often involves multiple joints, and like many other complex chronic conditions, is not a single disease but a heterogeneous condition with various risk factors. This project will investigate the role of increased intestinal permeability (i.e., “leaky gut”) as a contributor to development and worsening of osteoarthritis at multiple joint sites in humans and a naturally- occurring osteoarthritis model in pet dogs, to advance our understanding of this nascent area of study, improve risk stratification, and lay the groundwork for novel therapeutic development. The proposed work, in a high- priority topic area for NIAMS (NOT-AG-19-037), represents a necessary step towards understanding risk factors and outcomes in this common and frequently debilitating condition.

PI_NAMEs: LASCELLES, DUNCAN ;NELSON, AMANDA E (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: absorption;Address;Affect;aged;American;Animal Model;Area;Biological Markers;biomarker identification;Biopsy;Black race;Blood specimen;Body Burden;burden of illness;Canis familiaris;Clinical;cohort;Colon;comorbidity;complex chronic conditions;County;Data;Data Set;Degenerative polyarthritis;Development;disability;Disease;disease prognosis;effective therapy;Enrollment;Epithelial Cells;Exposure to;fecal microbiota;fecal transplantation;Foundations;Frequencies;fructooligosaccharide;functional status;Future;gut microbiome;Health;Hispanic Populations;Human;improved;Individual;Inflammation;Inflammation Mediators;inflammatory marker;Injury;innovation;intestinal epithelium;Intestinal permeability;Investigation;Iohexol;Joint by Site;Joints;Knee;Leaky Gut;lipopolysaccharide-binding protein;Lipopolysaccharides;Longitudinal cohort;Longitudinal Studies;Measures;men;microbial products;microbiome;microbiota;Modeling;mouse model;multimodality;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel marker;novel therapeutics;Outcome;Pain;Participant;Patients;Persons;Placebos;Plasma;prebiotics;predictive marker;progression marker;Public Health;radiological imaging;Randomized;Research;Risk;Risk Factors;risk stratification;Rodent Model;Role;Serum;Severities;Severity of illness;sugar;symptomatic improvement;Symptoms;systemic inflammatory response;Testing;therapeutic development;therapeutic target;Woman;Work

PROJECT_TITLE: Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogs

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: TB is the second most common cause of meningitis in sub-Saharan Africa and carries a 50% case mortality rate in part due to inadequate and/or costly diagnostic tests. The current testing paradigm leads to delayed diagnosis, reliance on empiric therapy, and poor outcomes. The overall objectives of this proposal are to improve TB meningitis outcomes by evaluating SILVAMP TB Lipoarabinomannan for TB meningitis (a test that may improve the speed and accuracy of TB meningitis diagnosis) and improving the understanding of the costs effectiveness of TB meningitis diagnostic strategies.

PI_NAMEs: BAHR, NATHAN  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Address;Africa South of the Sahara;antigen test;Area;Autopsy;Bacillus;Biological Assay;Cause of Death;Cerebrospinal Fluid;Cessation of life;clinical decision-making;clinical practice;cohort;cost;Cost Analysis;cost effective;cost effectiveness;Cost effectiveness research;Cost-Benefit Analysis;Data;Death Rate;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic strategy;Diagnostic tests;diagnostic tool;diagnostic value;effectiveness testing;Engineering;Guidelines;Health;HIV;Hospital Costs;Hour;improved;improved outcome;Incidence;Infrastructure;instrument;International;Investments;Japan;lipoarabinomannan;Meningeal Tuberculosis;Meningitis;Metagenomics;Morbidity - disease rate;mortality;mycobacterial;Neurological disability;next generation sequencing;novel;Outcome;Patients;Performance;performance tests;Persons;Pilot Projects;point of care;Predictive Value;Probability;Prospective cohort;rapid test;Reference Standards;Research;Resources;rural setting;Sampling;Specificity;Speed;standard of care;study population;Survivors;Techniques;Technology;Testing;Tokyo;Tuberculosis;tuberculosis diagnostics

PROJECT_TITLE: Determining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Rutgers SURF is a structured hands-on research and career development summer program designed to enhance scientific literacy and prepare undergraduate students for graduate and professional education and careers in toxicology and environmental health sciences. Real world application of toxicology principles are provided by field sampling for analysis of environmental contaminants. Our goal is to train the next generation of experimental and clinical environmental health scientists.

PI_NAMEs: ALEKSUNES, LAUREN M (contact);LASKIN, DEBRA L

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Achievement;Address;Admission activity;Award;Awareness;Basic Science;Biomedical Research;Biomedical Technology;Cancer Education Grant Program;carcinogenesis;career;career development;Clinical;Collaborations;Core Facility;design;Development;developmental toxicology;disadvantaged student;Disease;Diverse Workforce;Doctor of Philosophy;Education and Outreach;education evaluation;Educational workshop;Endocrine disruption;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Medicine;Environmental Pollutants;Epidemiology;Evaluation;experience;Faculty;faculty mentor;Fellowship;Fellowship Program;field study;field trip;formative assessment;Funding;Future;Goals;Graduate Education;graduate school;graduate school preparation;Grant;GRE Preparation;Guidelines;hands on research;Health;Health Sciences;high school;Human;human disease;Immunotoxicology;Infrastructure;innovation;Instruction;Joints;Laboratories;Leadership;Letters;literacy;Machine Learning;matriculation;medical schools;Medicine;meetings;member;Mentors;Mentorship;microbiome;Mission;National Institute of Environmental Health Sciences;next generation;Occupational Health;Occupational Medicine;Oral;Outcome;outreach program;Participant;Peer Review;Pharmacologic Substance;Pharmacy facility;Pharmacy Schools;Play;Poison;post-doctoral training;posters;pre-doctoral;Preparation;Professional Education;Program Effectiveness;Program Evaluation;programs;Public Health Schools;Publications;real world application;Recommendation;Records;recruit;Research;research and development;Research Project Grants;Research Training;Residencies;Resources;responsible research conduct;Safety;Sampling;Science;scientific literacy;Scientist;Site;skills;Structure;student participation;Students;success;summer program;summer research;symposium;Technical Expertise;Technology;Toxicology;Training;Training Programs;Translational Research;undergraduate research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Vocational Guidance;Wood material;Writing

PROJECT_TITLE: Summer Research Experience Programs (R25)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because ascending thoracic aortic aneurysms and dissections are frequent causes of death in the United States, largely because current medications are ineffective. The project is relevant to the NHLBI’s mission because it focuses on the treatment and prevention of life-threating cardiovascular disease; the development of new, effective medications would prevent the progression of aortic disease and save the lives of patients with these conditions.

PI_NAMEs: LEMAIRE, SCOTT A;SHEN, YING H (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Aorta;Aortic Diseases;Aortic Injury;Apoptosis;ascending aorta;Atherosclerosis;Biomechanics;Cardiovascular Diseases;Cause of Death;Cell Death;Cell membrane;Cells;Clinical;Cytosol;Data;Development;Diabetic Angiopathies;Dilatation - action;Disease;Disease Progression;Dissection;DNA;DNA Damage;DNA-dependent protein kinase;Emergency Situation;Event;experimental study;Extracellular Matrix;Extravasation;Failure;Genetic Diseases;Goals;Heart failure;Hypertension;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;knock-down;Knockout Mice;Learning;Life;Link;Marfan Syndrome;Mediating;Mission;Mitochondria;Modeling;Molecular;mouse model;Mus;National Heart, Lung, and Blood Institute;Necrosis;novel;Operative Surgical Procedures;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;prevent;Prevention;Public Health;Research;Role;Rupture;sensor;Series;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Stimulator of Interferon Genes;Structure;TBK1 gene;Testing;therapeutic target;Thoracic Aortic Aneurysm;Tissues;treatment strategy;United States;Vascular Diseases;VDAC1 gene;Work

PROJECT_TITLE: Pro-inflammatory Pyroptotic Cell Death in Aortic Degeneration

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Cerebrovascular;Clinical Research;Genetics;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative The autoimmune disease giant cell arteritis (GCA) is an inflammatory blood vessel disease that targets the aorta and its major branches and causes blindness, stroke, aortic dissection and aortic aneurysm. This project seeks to understand the pathologic immune responses that attack the blood vessel wall and cause vessel occlusion and destruction. By applying new technologies to unravel the mistakes in the patients’ immune system and by defining how the artery itself supports the disease process, the project will aid in the discovery of novel biomarkers measuring the intensity of vascular inflammation and support the development of new therapeutic strategies.

PI_NAMEs: WEYAND, CORNELIA M. (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Affect;Amplifiers;Aneurysm;angiogenesis;Aorta;Aortic Aneurysm;Aortic Arch Syndromes;Aortitis;Arteries;Autoimmune;Autoimmune Diseases;autoinflammatory diseases;Automobile Driving;bench to bedside;Biological Models;Blindness;Blood Vessels;CD4 Positive T Lymphocytes;Cell Differentiation process;cell motility;Cell Physiology;Cells;Chimera organism;Citric Acid Cycle;Clinical;cohort;Complication;Cytokinesis;Data;Defect;Development;Disease;Dissection;DNA Damage;Effector Cell;effector T cell;Electron Transport;Endothelial Cells;Engraftment;Enzymes;Event;Experimental Designs;experimental study;Giant Cells;Granulomatous Arteritis;Human;Hyperplasia;IL17 gene;Immune;Immune response;Immune system;Immunity;In Vitro;in vivo;in vivo Model;Infiltration;Inflammatory;Inflammatory Infiltrate;inhibitor;Interferons;interleukin-21;interleukin-22;Ketoglutarate Dehydrogenase Complex;Life;loss of function;Macrophage;Maps;Measures;Medial;Mediating;Messenger RNA;Metabolic;Mitochondria;Modification;Molecular;mouse model;mRNA Stability;Mus;new technology;NF-kappa B;notch protein;Notch Signaling Pathway;NOTCH1 gene;novel marker;novel therapeutic intervention;Nuclear;nuclear division;Oncogenes;Organ;Paralysed;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Population;Process;Procollagen-Proline Dioxygenase;Production;programs;Proliferating;Proteins;Resources;response;RNA;RNA-Binding Proteins;Role;Second Messenger Systems;Signal Transduction;Site;Stroke;Succinate Dehydrogenase;Succinates;T-Lymphocyte;Temporal Arteritis;Testing;therapeutic target;Thinness;Tissues;TNF gene;Training;transcription factor;Vascular Endothelial Cell;vascular inflammation;Vascularization;Vasculitis;Veno-Occlusive Disease;Work

PROJECT_TITLE: The NOTCH Signaling Pathway in Large Vessel Vasculitis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative    Transcription is a fundamental cellular process whose proper regulation is essential to establishment and maintenance of healthy cell states. Transcription of genes that control cell state involves dynamic formation and dissolution of large assemblies of protein and RNA molecules called biomolecular condensates. This project aims to provide important new insights into transcription by studying the biochemical features and regulation of transcriptional condensates.

PI_NAMEs: YOUNG, RICHARD  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;Affinity;Architecture;Behavior;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biology;Cell Nucleus;Cell Physiology;cell type;Cells;Chemicals;Chemistry;Chromatin;Code;Collaborations;Drug Design;Educational process of instructing;Environment;Future;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Heterochromatin;insight;Investments;Maintenance;Mammalian Cell;Mentors;Nuclear;Output;Physical condensation;Physics;Process;programs;Property;Proteins;Regulation;Research;RNA;Scientist;small molecule;Specificity;Testing;Training;Transcriptional Regulation;Untranslated RNA

PROJECT_TITLE: Transcriptional regulation in mammalian cells

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Lay Narrative Birth defects that interfere with development of the brain and/or pituitary gland can cause hormone deficiency, intellectual disability, and death. Mice are an important laboratory mammal that can be used to understand the cause of human disease. We aim to characterize existing mouse strains that have brain and/or pituitary gland developmental defects to increase our understanding of the cause of human disease.

PI_NAMEs: CAMPER, SALLY A. (contact);DAVIS, SHANNON WILLIAM;ELLSWORTH, BUFFY SUE;RAETZMAN, LORI T

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Abnormal Cell;Affect;Antibodies;Bioinformatics;biological adaptation to stress;Biological Assay;Birth;Brain;Candidate Disease Gene;Caring;Categories;causal variant;Cell Culture Techniques;Cells;Central Nervous System;Cessation of life;Cilia;Complex;Congenital Abnormality;Cre driver;Cryopreservation;Data;data dissemination;Databases;Defect;Development;Disease;Dysmorphology;Embryo;Epigenetic Process;Equilibrium;Etiology;Face;Fertility;Functional disorder;Future;gene discovery;Gene Expression;Gene Expression Profiling;gene function;Genes;Genetic Diseases;Genetic Variation;Genotype;Goals;Gonadal structure;Growth;Histologic;Histological Techniques;Histology;Holoprosencephaly;Homeostasis;hormone deficiency;Human;human disease;Human Genetics;Hypopituitarism;Hypothalamic structure;In Situ Hybridization;insight;Intellectual functioning disability;International;Investments;Knockout Mice;Knowledge;Laboratories;Lethal Genes;malformation;Mammals;man;Meta-Analysis;Metabolism;Methods;Molecular Diagnosis;molecular phenotype;Morbidity - disease rate;Morphology;mortality;Mouse Strains;Mus;mutant;Mutation;Neurons;novel;Organogenesis;Partner in relationship;Pathogenesis;Pathway interactions;Patients;Penetrance;Persons;Phenotype;Pituitary Gland;pituitary gland development;Pituitary Hormones;Post-Translational Protein Processing;Pregnancy;Proliferating;Quantitative Reverse Transcriptase PCR;Reagent;Reporting;Research Personnel;Resources;Risk;Septo-Optic Dysplasia;single-cell RNA sequencing;Site;Specific qualifier value;Stains;Structural defect;Structure;Syndrome;Testing;Time;Tissues;transcription factor;treatment planning;United States National Institutes of Health;Vascularization;Water;web site;Wild Type Mouse;WNT Signaling Pathway;Work

PROJECT_TITLE: Discovery Pipeline for Genetic Defects in Hypothalamic-pituitary Development Using International Mouse Phenotyping Consortium Mice

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Heart Disease;Maternal Health;Neurosciences;Nutrition;Prevention;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE How breastfeeding improves the health of children has been extensively studied, but the maternal benefits are not well understood. Multiple observational studies have linked lactation with reduced maternal cardiovascular disease in later life. This novel study will clarify the role of lactation in maternal health and may lead to identification of mechanisms activated during pregnancy and lactation, which may be targeted for interventions to prevent cardiovascular disease in women.

PI_NAMEs: BYTAUTIENE PREWIT, EGLE  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adipose tissue;ADP-ribosyl Cyclase;Affect;Age;antagonist;Behavior;Birth;Blood Pressure;blood pressure reduction;Blood Vessels;Body Weight;Bottle feeding;Brain;Brain region;Breast Feeding;Cardiac;Cardiometabolic Disease;cardioprotection;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Cerebellum;Child Health;Chronic Disease;conditional knockout;design;Development;Diastolic blood pressure;Discipline of Nursing;Echocardiography;EFRAC;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;Event;Exposure to;fasting glucose;Feedback;Foundations;Functional disorder;Future;Gender;Gene Expression;Goals;Health;Heart;heart function;High Fat Diet;Hour;Human;Hypertension;Hypothalamic structure;improved;In Vitro;in vivo;Infant;Intervention;Knockout Mice;Lactation;lactation period;late life;Life;Link;Long-Term Effects;Low-Density Lipoproteins;LoxP-flanked allele;magnocellular;Maternal Health;Measures;Mediating;men;Messenger RNA;Metabolic;Metabolic syndrome;micrography;Milk;Milk Ejection;Modeling;Mothers;Mus;Neurons;Neuropeptides;Newborn Infant;Nipples;novel;Obesity;Observational Study;offspring;Operative Surgical Procedures;Organ;Outcome;Output;Oxytocin;Oxytocin Receptor;paraventricular nucleus;Pattern;Peripheral;Phenotype;Physiological;placebo group;Plasma;Play;post pregnancy;Postpartum Period;Pregnancy;pregnant;prevent;Procedures;Production;Prosencephalon;pup;Reflex action;Regulation;Reporting;Risk Marker;Role;social;Social Behavior;Stroke Volume;suckling;supraoptic nucleus;System;Testing;Therapeutic;Time;Translating;Uterine Contraction;Visceral;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Lactation, oxytocin and maternal cardiovascular function later in life

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PD/PI: Takemaru, Ken-Ichi 8. PROJECT NARRATIVE Infertility is a public health issue, affecting approximately 15% of all couples, and in about 50% of cases, a male factor is involved. The sperm flagellum is responsible for sperm motility and fertilization of the egg, but how flagella are properly formed remains poorly understood. Our research focuses on understanding the roles of Chibby (Cby) family members and their binding proteins in the formation and function of sperm flagella, thereby contributing to our better understanding of male germ cell development.

PI_NAMEs: TAKEMARU, KEN-ICHI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Affinity Chromatography;Apical;asthenospermia;base;Binding;Binding Proteins;Biogenesis;Biological Process;Cell surface;Cilia;ciliopathy;cilium biogenesis;cilium motility;Complex;constriction;Couples;Curiosities;Cystic kidney;Data;Defect;Development;Diffusion;Diploidy;Disease;Dislocations;Exhibits;Family member;Fertility;Flagella;Goals;Haploidy;Human;Hydrocephalus;in vivo;Infertility;insight;Laboratories;Lipid Binding;Liquid substance;Locomotion;male;male fertility;Male Infertility;Mammalian Cell;Mass Spectrum Analysis;Meiosis;Membrane;Membrane Lipids;men;Microtubules;migration;Mitotic;Modeling;Molecular;Morphology;Motility;mouse model;Movement;Mus;novel;Nuclear;Pancreas;Patients;Phase;Phenocopy;Phenotype;Physical condensation;Physiological;Play;Polydactyly;Positioning Attribute;Primary Ciliary Dyskinesias;Process;Property;protein protein interaction;Proteins;Public Health;Reporting;Research;Respiratory Tract Infections;Role;Shapes;Signal Transduction;sperm cell;Sperm Count Procedure;sperm function;Sperm Motility;Sperm Tail;Spermatids;Spermatocytes;Spermatogenesis;Spermiogenesis;stem cells;Structure;Swimming;Tail;Tertiary Protein Structure;Testis;Vertebrates;Work;zygote

PROJECT_TITLE: The Role of Chibby Family Members in Spermatogenesis and Male Fertility

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Mental Health;Nanotechnology;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research will develop scalable and cost-effective gene therapy to elicit directed immunity against human immunodeficiency virus infections which impact tens of millions of patients worldwide. We are proposing to use gold nanoparticles to deliver precise genetic insertion of broadly neutralizing antibody genes against HIV in immune cells and repopulating hematopoietic stem and progenitor cells inside the body. This single step approach combines the latest CRISPR delivery technology with a new strategy to direct humoral immunity which could represent a one-time treatment with cure potential for persons living with HIV.

PI_NAMEs: ADAIR, JENNIFER EILEEN (contact);TAYLOR, JUSTIN J

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Anti-Retroviral Agents;Antibodies;antibody engineering;Antibody Formation;Antibody Therapy;Antigens;Autologous Transplantation;B-Lymphocytes;Bar Codes;Binding;Blood Cells;Bone Marrow;Cell surface;Cell Survival;cell type;Cells;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cost;cost effective;Coupling;Data;design;DNA;Engineering;Ensure;Epidemic;Equity;experience;fitness;Frequencies;Gene Delivery;gene therapy;Genes;Genetic;Genetic Engineering;genetically modified cells;Half-Life;Hematopoietic stem cells;HIV;HIV Infections;Human;Human Herpesvirus 4;Humoral Immunities;Immune;Immunity;immunodeficiency;immunogenic;Immunoglobulin G;Immunoglobulin-Secreting Cells;Immunology;improved;in vivo;in vivo evaluation;influenzavirus;Injections;Interruption;Intervention;Laboratories;Life;lipid nanoparticle;Liver;manufacture;Mediating;Memory B-Lymphocyte;Modeling;Molecular Target;mouse model;Mus;nanoformulation;nanoGold;nanoparticle;Nature;neutralizing antibody;nonhuman primate;novel;novel strategies;Patients;Persons;Pharmaceutical Preparations;Plasma Cells;preference;prevent;Process;Proliferating;promoter;Research;Resources;Respiratory syncytial virus;Risk;Science;side effect;simian human immunodeficiency virus;Single-Stranded DNA;Source;success;Surface;synergism;System;Technology;Testing;Therapeutic;therapeutic genome editing;Tissues;tool;Transplantation;Vaccines;Viral;viral rebound;Viral Vector;Virus Diseases;Work

PROJECT_TITLE: In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticles


NIH_SPENDING_CATS: Biotechnology;Childhood Injury;Congenital Structural Anomalies;Genetics;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Unintentional Childhood Injury

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE  The proposed research is focused on understanding the mechanism of Hox function in regulating skeletal differentiation. Loss of Hox function impacts the ability of skeletal stem/progenitors to complete differentiation down the osteogenic and chondrogenic lineages via unknown pathways. The conserved, region-specific, expression of Hox genes in the skeletal stem/progenitors (MSCs) in all vertebrates, including humans, supports the significance and relevance of these studies and fulfills the mission and goal of the NIH to understand the processes of human growth and development.

PI_NAMEs: WELLIK, DENEEN M (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Adipocytes;Adult;Alleles;Animal Model;Animals;Apoptosis;Binding;Binding Sites;Biology;Biometry;bone;bone fracture repair;Bypass;Candidate Disease Gene;Cartilage;Cell Culture Techniques;Cell Differentiation process;Cells;Chondrocytes;Chondrogenesis;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collection;comparative;conditional mutant;Control Animal;Data;Defect;Differentiation Antigens;differentiation in vitro;Embryo;Embryonic Development;Epitopes;Event;experimental study;Forelimb;Fracture;Gene Expression Profiling;gene function;Genes;Genetic;Genomics;Goals;Growth;Growth and Development function;Homeobox Genes;Homeostasis;Human;In Vitro;in vivo;Injury;innovation;Knock-in;Knowledge;Label;Laboratories;Life;loss of function;Maps;Mediating;Mission;Modeling;Molecular;morphogens;Morphology;Mus;mutant;Osteoblasts;Osteocalcin;Osteocytes;Osteogenesis;osteogenic;osteopontin;Pathway interactions;Pattern;Phenotype;Play;Population;Positioning Attribute;Process;progenitor;Publishing;Radial;Regulation;repaired;Reporter;Reporting;Research;Research Personnel;Research Proposals;Resolution;response to injury;Role;self-renewal;Site;skeletal;Skeletal Development;skeletal stem cell;Skeleton;stem;stem cells;Testing;Time;Tissue-Specific Gene Expression;tool;transcription factor;transcriptomics;ulna;United States National Institutes of Health;unsupervised clustering;Vertebrates;virtual;Visualization;Work

PROJECT_TITLE: Hox-Regulated MSCs in Skeletal Development, Growth and Fracture Healing

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: KNOXVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative Membranes are barriers of proteins, fats, and sugars that form the borders of all living cells on earth, and are essential to cellular viability; understanding how membranes function is crucial for many key areas of biomedicine including cancer, drug resistant infections, development, drug delivery, and energy production. However, future progress in membrane research requires that a new generation of scientists be trained who can combine approaches and concepts from many disparate fields such as physics, chemistry, biology, and computer science. The Integrated Membrane Program (IMP) training grant is especially designed to train scientists to integrate multiple approaches to address these next-generation challenges.

PI_NAMEs: REYNOLDS, TODD B (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Membrane;programs

PROJECT_TITLE: Integrated Membrane Program (IMP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biotechnology

PHR: NARRATIVE  The Cellular Biotechnology Training Program at the University of Michigan reaches across traditional academic boundaries to provide diverse body of graduate students from a variety of scientific backgrounds with multidisciplinary training related to biotechnology and guidance about a wide-range of scientific career options. Our goal is to train future leaders who can transform human health through biotechnological innovation.

PI_NAMEs: SCHWENDEMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Biotechnology;Training Programs

PROJECT_TITLE: Cellular Biotechnology Training Program (CBTP) - Years 31-35

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Hydrogen peroxide is a signaling molecule used by cells to sense, adapt and respond to their environment. We propose to investigate the mechanisms by which hydrogen peroxide signals at cell membranes and how this impacts cellular processes such as vesicular trafficking and migration which are important for in many human diseases. The results of these studies will allow us to explore potential new strategies for the prevention and treatment of a broad range of disorders including inflammatory diseases, cancer and neurodegeneration.

PI_NAMEs: THIAGARAJAH, JAY  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Area;Biological;Cell membrane;Cell Membrane Permeability;cell motility;Cell Physiology;Cells;Cellular Membrane;Cysteine;Development;Disease;Environment;environmental change;Enzymes;Epithelial Cells;Eukaryotic Cell;fluorescence imaging;Future;Generations;Homeostasis;Human;human disease;Hydrogen Peroxide;Immune response;Immune signaling;Inflammatory;Malignant Neoplasms;Membrane;migration;Modification;NADPH Oxidase;Nerve Degeneration;novel;Oxidation-Reduction;Pathway interactions;Permeability;Plants;Prevention strategy;protein structure;Proteins;Proteomics;Reactive Oxygen Species;Regulation;Research;Resolution;Signal Transduction;Signaling Molecule;Stress;Sulfhydryl Compounds;Surface;Tissues;tool;trafficking;water channel

PROJECT_TITLE: Decoding Hydrogen Peroxide Signaling at Cellular Membranes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This proposal will produce high quality genome assemblies of An. squamosus and An. cydippis that are critical in understanding malaria transmission in Zambia. The resulting genomes will also be sufficient to develop a diagnostic assay for rapid screening of adults and any life stages where species-specific morphological features are not apparent. The new genomic resources for An. squamosus can be leveraged for studying mosquito vector behavior and devise effective control strategies of understudied malaria vectors in pre- elimination settings.

PI_NAMEs: LEE, YOOSOOK  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Anopheles Genus;Area;barrier to testing;Beds;Behavior;Biological Assay;Bite;California;Chromosomes;Collection;Complex;Conserved Sequence;contig;Culicidae;cytochrome c oxidase;Data;design;Development;Diagnostic;diagnostic assay;DNA Library;DNA sequencing;epidemiology study;evidence base;experience;First Generation College Students;Florida;Foundations;functional genomics;Genbank;Genes;Genetic;genetic information;Genetic Polymorphism;Genome;genome resource;Genomics;Genotype;Goals;Human;Hybrids;Improve Access;improved;Individual;infection rate;Insecticide Resistance;Insecticides;Larva;Life;Link;Malaria;malaria infection;malaria transmission;Manuals;Mitochondria;model organism;Modeling;Morphology;neglect;Orthologous Gene;Oxidases;Parasites;Phenotype;Plasmodium falciparum;Population;Predisposition;preference;Procedures;Process;Pupa;Rapid diagnostics;Rapid screening;reference genome;Research;Residual state;Risk;Sampling;scaffold;Scientist;sequencing platform;Siblings;Southern Africa;Sporozoites;therapeutically effective;Training;trait;transcriptome sequencing;transmission process;Trust;Universities;vector;vector competence;vector control;Vector Ecology;vector mosquito;Work;Zambia

PROJECT_TITLE: Development of high-quality reference genomes for Anopheles squamosus and An. cydippis

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CHICAGO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative Chronic pain is a major public health problem, and there is a need for novel effective treatments that do not target opioid receptors. Acetylcholine is an important neuromodulator in the brain, and we found that its levels are reduced in descending pain control circuitry under acute and chronic pain conditions. Here, we will explore how pain reduces acetylcholine release, and whether reversing this maladaptive change can lead to novel analgesic treatments.

PI_NAMEs: MCGEHEE, DANIEL S (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: abuse liability;Acetylcholine;Acute Pain;Adult;Affective;Affective Symptoms;Agonist;allodynia;American;Analgesics;Anatomy;Behavior;behavior test;Behavioral;Biological Assay;Brain;Calcium;Cell Nucleus;Cells;Central Nervous System;cholinergic;cholinergic neuron;Chronic inflammatory pain;chronic neuropathic pain;chronic pain;chronic pain management;chronic painful condition;Complement;Data;Development;Disinhibition;effective therapy;Electrophysiology (science);endogenous opioids;experimental study;Face;Fiber;gamma-Aminobutyric Acid;Genetic;Hyperalgesia;Image;in vivo;in vivo imaging;Individual;Induced Neurons;Interneurons;Investigation;Methods;Microdialysis;midbrain central gray substance;Midbrain structure;Molecular;Monitor;Muscarinics;Neuromodulator;neuronal excitability;Neurons;neurotransmitter release;Nociception;non-opioid analgesic;novel;novel therapeutics;Opioid;opioid epidemic;Opioid Receptor;Pain;pain inhibition;Pain management;Pain Measurement;pain reduction;pain relief;pain sensitivity;pain symptom;Pathway interactions;Pattern;Pedunculopontine Tegmental Nucleus;pedunculopontine tegmentum;pharmacologic;Photometry;Physiological;Physiology;Plague;postsynaptic;presynaptic;Public Health;receptor;sensor;side effect;Signal Transduction;Site;Slice;Stimulus;Synapses;System;Testing;two-photon;United States

PROJECT_TITLE: Midbrain cholinergic modulation of pain states

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: Narrative  Best known for a role in maintaining cancer cell immortality, the telomerase enzyme TERT also protects cancer cells from radiation therapy. Here, we will study new TERT blocking agents as model drugs to sensitize cancer to radiation in cell lines and in experimental tumors. Success may lead to highly cancer-specific agents that will improve patient outcomes.

PI_NAMEs: KRON, STEPHEN J. (contact);SCHEIDT, KARL A

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Abscopal effect;Acceleration;Active Sites;Address;Adverse effects;Affect;Affinity;analog;Aneuploidy;anti-tumor immune response;Antibiotics;Apoptosis;Biological Assay;cancer cell;Cancer Patient;Caring;Cell Aging;Cell Death;Cell division;cell immortalization;cell injury;Cell Line;Cell Proliferation;Cell Survival;Cells;Characteristics;Chemicals;Clinic;Clinical;clinically significant;Combined Modality Therapy;Cysteine;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;Distant;DNA;DNA Damage;Dose;Double Strand Break Repair;drug development;Drug Modelings;Drug Targeting;Enzymes;Excision;Experimental Neoplasms;Failure;Gene Expression;Genotoxic Stress;Growth;Hand;homologous recombination;image guided;immune checkpoint blockade;Immune Evasion;immunogenic;immunogenicity;Immunologic Cytotoxicity;improved;in silico;In Vitro;in vivo;Inbred BALB C Mice;Infiltration;Inflammation;Inflammatory Infiltrate;inhibitor;Ionizing radiation;irradiation;lead optimization;Malignant Neoplasms;Measures;Mediating;Modeling;Modernization;Modification;Molecular Target;Mus;natural product inspired;Natural Products;Neoplasm Metastasis;neoplastic cell;Nonhomologous DNA End Joining;Normal Cell;Normal tissue morphology;novel;Outcome;oxidative damage;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pre-clinical;programmed cell death ligand 1;Property;Publishing;Radiation;radiation resistance;radiation response;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Reaction;Recurrence;repaired;Resistance;response;Reverse Transcriptase Inhibitors;RNA-Directed DNA Polymerase;Role;Safety;senescent cell;Series;Signal Transduction;Solid Neoplasm;Structure;success;Supporting Cell;T-Cell Proliferation;targeted agent;Telomerase;Telomerase inhibition;Telomerase Inhibitor;telomere;TERT gene;Therapeutic;Therapeutic Index;Tissues;Toxic effect;Translating;Treatment Efficacy;tumor;Tumor Immunity;tumor progression;Validation;Work

PROJECT_TITLE: PAIRS: Validating telomerase reverse transcriptase (TERT) as an intrinsic vulnerability toward sensitizing cancer to radiation

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Overweight and obesity is a associated with fatal diseases such as type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and cancer. Recent research shows that a special type of fat—called brown fat—is present in adult humans and it has a remarkable capacity to “burn off” excess calories (nutrients) rather than store them as fat when active. Adults with brown fat are often healthier, and to better understand why, we investigate here how brown fat uses different nutrients in response to the diverse stimuli that activate it with the goal of identifying therapeutic strategies to increase brown fat energy expenditure.

PI_NAMEs: GUERTIN, DAVID A (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Adrenergic beta-Agonists;Adult;aerobic glycolysis;Affect;Ammonia;Anabolism;angiogenesis;Area;Arginine;Astronomy;Back;Biochemistry;Biology;Body Temperature;Brown Fat;Calories;Carbon;Cardiovascular Diseases;Chronic;Circulation;Citric Acid Cycle;Clinical;Communication;comorbidity;Complex;Consumption;cost;Coupled;Data;detection of nutrient;Diet;diet and exercise;Disease;Energy Metabolism;Engineering;Environment;Enzymes;Epidemic;Fatty acid glycerol esters;fluorodeoxyglucose positron emission tomography;Food;Gender;Genetic;Glucose;Glutamine;Goals;Healthcare;High Fat Diet;Homeostasis;Human;Hyperglycemia;improved;in vivo;innovation;Label;Left;Life Style;lipid metabolism;Lipids;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Diseases;metabolic fitness;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Methods;Mitochondria;Modeling;N acetyl L glutamate;Nitric Oxide;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrition;Obesity;Organ;Overweight;oxidation;pandemic disease;Pathology;Pathway interactions;PET/CT scan;Physiological;Process;Production;Prognosis;Property;Protocols documentation;Reporting;Research;response;Rest;Role;sedentary lifestyle;Sense Organs;Source;stable isotope;Stimulus;synergism;Techniques;Technology;Testing;Therapeutic;therapeutic target;thermal stress;Thermogenesis;trend;tumor growth;Urea;Venous;Warburg Effect

PROJECT_TITLE: Quantitative and functional analysis of brown fat nutrient fluxes in vivo and its role in organ metabolite exchange

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Understanding how cellular behaviors add up to organ-scale phenotypes requires the ability to observe organs in their native contexts, with subcellular resolution, over sufficiently long periods to capture long-timescale processes. My lab has pioneered live imaging techniques that enable us to make long-term and longitudinal observations in the Drosophila midgut, a superb model for stem cell and epithelial organ biology. Here, we propose how stem cells array themselves to respond to and replace cells that are being eliminated from the tissue as well as how new, differentiating cells integrate into existing cellular networks.

PI_NAMEs: O'BRIEN, LUCY ERIN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;adult stem cell;Biological Models;Biology;cell behavior;Cell Death;Cell Differentiation process;cell motility;Cells;Complex;Drosophila genus;EGF gene;Epithelium;Equilibrium;Feedback;flexibility;Funding;Goals;grasp;Health;Homeostasis;Human;imaging capabilities;Imaging Techniques;in vivo;Individual;Kinetics;Life Cycle Stages;Maintenance;Midgut;Organ;Organ Model;Organ Size;Output;Phenotype;Population;precision genetics;Process;programs;Property;Regulation;repaired;Resolution;seal;self-renewal;Signal Transduction;Small Intestines;Source;Spatial Distribution;stem cell division;stem cell model;stem cells;stemness;Stomach;Thinking;Tight Junctions;Time;Tissues;tool;Tubular formation;Work

PROJECT_TITLE: Organ-scale regulation of stem cell dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NORFOLK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: We will analyze cellular and membrane mechanisms of excitation of neurons by modulated periodic stimuli and introduce a novel paradigm of non-invasive deep brain stimulation. We will design, test, and tune new protocols for the next generation temporal interference stimulation. We will utilize the novel interference targeting protocols for neuromodulation selectively at a distance, for clinical applications such as non-invasive deep brain stimulation.

PI_NAMEs: PAKHOMOV, ANDREI G (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: addiction;Animal Experiments;Animals;attenuation;Brain;Brain region;Calibration;Cells;Cephalic;Charge;chronic pain;Clinical;clinical application;Consumption;Deep Brain Stimulation;Dementia;design;Disease;disease diagnosis;disease diagnostic;electric field;Electric Stimulation;Electrodes;Epilepsy;Evaluation;experimental study;FOS gene;Frequencies;Health;Hemorrhage;High Frequency Oscillation;Human;Implanted Electrodes;improved;in silico;In Vitro;in vivo;Individual;Infection;Inflammation;interest;Ion Channel;Knowledge;Lead;Link;Location;Medical;Membrane;Membrane Potentials;Mental Depression;Methods;Modeling;Movement Disorders;Muscle;Nerve;Nerve Fibers;neural;neuronal circuitry;Neurons;neuroregulation;neurosurgery;neurotransmission;next generation;novel;Optics;Parkinson Disease;Penetration;Periodicals;Peripheral Nervous System;peripheral pain;Phase;Physiological;predictive modeling;prevent;Property;Protocols documentation;Ramp;Reporting;Research;Resolution;Risk;Signal Transduction;simulation;Site;Speed;Stimulus;Stroke;Surface;Technology;Testing;Tissues;tool;Translating

PROJECT_TITLE: Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The mission of the Pittsburgh Biomedical Informatics Training Program is to prepare trainees to become outstanding leaders in biomedical informatics research, education, and practice, through world-class training with a focus on artificial intelligence and computing methods for biomedical problems. This proposed renewal will support upcoming predoctoral, postdoctoral, and short-term trainees in translational bioinformatics, clinical informatics, imaging information, clinical research informatics, and public health informatics. Enhanced plans for recruitment, outreach, and evaluation will strengthen and diversify our program.

PI_NAMEs: HOCHHEISER, HARRY S (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Academia;Administrator;Admission activity;Appointment;Award;Bioinformatics;biomedical informatics;Clinical Informatics;Clinical Research;Data Science;Doctor of Philosophy;doctoral student;Educational Curriculum;Environment;Equipment;Evaluation;Evolution;experience;Expert Systems;Faculty;Financial Support;Funding;Goals;Government;Healthcare;imaging informatics;Industry;Informatics;Institution;Internships;Journals;Leadership;Medical;Medical center;medical schools;member;Mentors;Minority-Serving Institution;outreach;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Public Health Informatics;Publishing;Recording of previous events;recruit;Research;Research Personnel;Research Training;Schools;Scientist;Secure;Training;Training Programs;United States National Institutes of Health;Universities


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Hematology;Pediatric;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOULDER

ORG_NAME: BOLDER BIOTECHNOLOGY, INC.

ORG_STATE: CO

PHR: Narrative Because of the increasing threat of a terrorist nuclear attack or radiological accident, the US government is urgently supporting development of drugs to treat the hematopoietic acute radiation syndrome (H-ARS), which is the leading cause of death during the first 30 to 60 days following exposure to radiation doses greater than 2 Gy. The few drugs that have been approved by the FDA to treat H-ARS increase survival when administered within 24h of radiation exposure, but do not increase survival when administered 48h post-irradiation in animal H-ARS models. This grant further characterizes a novel drug and 3 drug combination that significantly improves survival when administered 48h following radiation exposure and potentially could become life-saving treatment options for a heretofore untreatable H-ARS population – patients who cannot be treated until 48h or later post-irradiation.

PI_NAMEs: COX, GEORGE NORBERT (contact)

PROGRAM_OFFICER_NAME: RIOS, CARMEN I

PROJECT_TERMS: Acceleration;Acute;Acute-Phase Proteins;Age;age related;Agonist;Anemia;Angiotensin-Converting Enzyme Inhibitors;Animals;Applications Grants;Awareness;Biological Assay;Biological Markers;Blood Cells;Blood Platelets;Bone Marrow;C57BL/6 Mouse;Cause of Death;Cell Count;chemokine;Childhood;Clinical Trials;CSF3 gene;cytokine;Dose;drinking water;Drug Combinations;drug development;Drug Kinetics;Drug usage;emergency settings;Emergency Situation;Exposure to;FDA approved;Filgrastim;Future;GMP lots;Government;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Hematopoietic;Hematopoietic Cell Growth Factors;Hematopoietic stem cells;Hemorrhage;Hour;Human;improved;Inbreeding;Individual;Infection;Inflammatory;Interleukin-1;Interleukin-11;irradiation;Knowledge;Life;Lisinopril;Lymphopenia;manufacture;Medical;Miniature Swine;Modeling;Mouse Strains;Mus;Neutropenia;neutrophil;nonhuman primate;novel;novel drug combination;novel therapeutics;Nuclear;Nuclear Radiology;Nuclear Warfare;patient population;Patients;Pegfilgrastim;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;Phase;Plasma;protein structure;Proteins;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;radiation mitigator;Radiation Tolerance;Radiation Toxicity;Radiology Specialty;Recovery;Safety;safety testing;Sampling;sargramostim;sex;stem;stem cells;Sterility;Survival Rate;Testing;Therapeutic;Thrombocytopenia;Time;Tissues;Toxicology;Whole-Body Irradiation;young adult

PROJECT_TITLE: Novel drug combinations for improving survival from acute radiation syndrome when administered 48 hours post- irradiation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE K01 support will allow me to establish myself as an independent researcher on cardiovascular disease disparities with expertise in Bayesian nonparametric clustering techniques and nutrition epidemiology. Training activities will focus on deepening my understanding of cardiovascular disease epidemiology, nutrition epidemiology, and health disparities, enabling me to model and evaluate the role of modifiable exposures such as diet in understudied populations. My research activities will focus on developing methodologies to gain new insight into population-based dietary exposure patterns of US women and their contribution to cardiovascular health disparities, which will ultimately inform the development of nutrition policy interventions suitable for vulnerable subgroups to promote population health equity.

PI_NAMEs: STEPHENSON, BRIANA JOY KENNEDY (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Address;Adherence;Adult women;Age;aged;Attention;Award;Behavior;Beverages;Biometry;Black race;black women;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;Cessation of life;Clinical;cohort;Cohort Studies;Communities;Computer software;Consumption;COVID-19 pandemic;Data;Death Rate;Dependence;Development;Diabetes Mellitus;Diet;dietary;Dietary Assessment;Dietary Component;Dietary intake;Dietary Practices;disease disparity;disparities in women;Disparity;Educational workshop;Elements;Epidemiology;Ethnic Origin;Ethnic Population;Event;experience;Food;Foundations;Funding;Future;Goals;Health;health disparity;health equity;high dimensionality;high risk;Hispanic Women;Hypertension;improved;Incidence;Individual;innovation;insight;Interdisciplinary Study;Intervention;Lead;Longitudinal Studies;marginalization;Measures;method development;Methodology;Methods;Modeling;Nurses;Nurses' Health Study;Nutrient;nutrition;Nutrition Policy;Nutritional;nutritional epidemiology;Nutritional Study;Obesity;Outcome;Pattern;Policies;Population;population based;population health;Population Heterogeneity;programs;Race;Recommendation;Research;Research Activity;Research Design;Research Personnel;Risk;Risk Estimate;Risk Factors;Role;skills;Socioeconomic Factors;software development;Statistical Methods;Subgroup;symposium;Techniques;Time;time use;Training;Training Activity;Unhealthy Diet;United States;United States National Institutes of Health;usability;Vocational Guidance;Vulnerable Populations;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Statistical methods to understand changes in dietary patterns over time and cardiovascular disease risk among understudied populations


ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative  State-of-the-art biomedical research is highly multidisciplinary, requiring contributions from a diverse group of researchers. The Chemistry-Biochemistry-Biology Interface (CBBI) Program at the University of Notre Dame has met the challenge for cross-disciplinary training and has produced researchers with a synergistic combination of highly rigorous scientific skills, a broad knowledge base across both chemistry and biological disciplines, and excellent communication skills. Our goal is to continue to train PhD scientists with the skillsets and knowledge to solve challenging and significant biomedical problems, regardless of discipline.

PI_NAMEs: MELANDER, CHRISTIAN COREY (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biochemistry;Biology;Chemistry;programs

PROJECT_TITLE: Chemistry-Biochemistry-Biology Interface (CBBI) Program at Notre Dame


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UCLA Biomedical Data Science Training Program for Precision Health Equity is aimed at creating the next generation of scientists who are equipped to translate cutting-edge computational methods into practice for im- proving more individually-tailored medicine. Tapping into leading experts with significance experience in develop and translation of key methods, trainees in this program will have mentorship and learning experiences that establish a deep appreciation for both the technological and the social elements that relate to adoption of new approaches like precision heath. Through this training program, a new type of scientist able to realize the vision of precision health – for everyone – will be created with an ability to transform research into practice.

PI_NAMEs: BUI, ALEX  (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Area;Bioinformatics;biomedical data science;biomedical informatics;clinical care;Clinical Informatics;Clinical Research;Communication;Computing Methodologies;Data Science;Data Scientist;Disease;diversity and equity;Educational Curriculum;Electronic Health Record;empowerment;Equity;experience;Faculty;Fostering;Genomics;Goals;Growth;hands on research;Health;health care delivery;health equity;Health Policy;Human;improved;Individual;Informatics;innovation;insight;Institution;Knowledge;Learning;Medicine;Mentorship;Methods;mHealth;novel;Patients;Personal Satisfaction;Precision Health;precision medicine;programs;Public Health;Public Health Informatics;Research;Science;Scientific Advances and Accomplishments;Scientist;Shapes;skills;Source;Students;Techniques;Technology;Thinking;tool;Training;Training Programs;Translating;Translations


NIH_SPENDING_CATS: Precision Medicine

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The research program proposed here seeks to develop computer models to understand how the metabolic activity of cells impact the potency of drug treatment. We will uncover mechanisms that link metabolite levels with the activity of various cellular processes and their corresponding sensitivity to drug inhibition. This study will complement precision medicine efforts by identifying treatments that are most effective based on a cell’s metabolic state.

PI_NAMEs: CHANDRASEKARAN, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Algorithms;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Complement;Computer Models;drug action;Drug Combinations;drug discovery;drug sensitivity;Drug Targeting;Environment;Enzyme Inhibitor Drugs;Escherichia coli;Genetic Transcription;Goals;Human Cell Line;in vivo;Link;Metabolic;Metabolism;novel strategies;Nutrient;Organism;Pharmaceutical Preparations;Pharmacotherapy;precision medicine;Predisposition;programs;Regulation;Research;response;Signal Transduction;System;Systems Biology;Testing;tool;uptake;Yeasts

PROJECT_TITLE: Linking metabolic activity with drug sensitivity using metabolic influence networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Sepsis is a critical illness often associated with blood clotting dysfunction and carries extremely high mortality. The goal of the proposed study is to investigate the molecular mechanism of platelet activation and dysfunction during sepsis and to identify potential treatment target.

PI_NAMEs: WILLIAMS, BRITTNEY  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Adhesions;Binding;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;cecal ligation puncture;cell injury;Cells;Circulation;Clinical;Coagulation Process;Complication;Consumption;Critical Illness;cytokine;Data;Disease;Elements;extracellular vesicles;Family;Fibrinogen;Functional disorder;Generations;Goals;Hemostatic Agents;HIV;Immune;Immune response;Immunologic Receptors;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;Interleukin-1 beta;Intravascular Thrombus Formation;Invaded;Knockout Mice;Leukocytes;Ligands;Link;Literature;loss of function;Mediator;MicroRNAs;Modeling;Molecular;mortality;mouse model;Mus;new therapeutic target;novel;Organ failure;organ injury;pathogen;Pathogenesis;Pattern;Pattern recognition receptor;pharmacologic;Pilot Projects;Plasma;Platelet Activation;Platelet aggregation;Platelet Count measurement;platelet function;platelet preservation;Play;Prevention;Production;Proteins;receptor;response;RNA;Role;sensor;Sepsis;septic;Serotonin;Severities;Signal Transduction;systemic inflammatory response;Testing;therapeutic evaluation;therapeutic target;Thrombin;Thrombocytopenia;Thromboplastin;Thrombus;Time;TLR7 gene;Toll-like receptor 11;Toll-like receptors;Treatment Efficacy;vascular inflammation;Wild Type Mouse

PROJECT_TITLE: Role of miRNA-TLR7 signaling in platelet activation and dysfunction in sepsis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Numerous human diseases have as a major indication epithelial barrier dysregulation and the Ah receptor (AHR) has recently been shown to play an emerging role in the maintenance of epithelium and local immune status in barrier tissues, such as skin and the intestinal tract. We propose to identify and characterize the multiple sources of AHR ligands, determine the appropriate level of AHR ligand exposure that leads to optimal barrier tissue homeostasis and examine how low dose exposure to environmentally relevant potent AHR ligands may influence barrier tissue function. The possibility of using the AHR as a therapeutic target to enhance barrier tissue function will also be explored with a series of selective AHR modulators/agonist.

PI_NAMEs: PERDEW, GARY H. (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Affect;Agonist;Aryl Hydrocarbon Receptor;Atopic Dermatitis;chemokine;Chronic Disease;commensal microbes;Complex;Complex Mixtures;Confusion;cytokine;Diet;dietary;Disease;Dose;Economic Burden;Environment;Environmental Pollution;epithelial repair;Epithelium;exposed human population;Exposure to;Growth Factor;Health;Homeostasis;Human;human disease;Immune signaling;Immunologic Surveillance;immunological status;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Intention;Intestinal Mucosa;Intestines;Knowledge;Laboratories;Lead;Ligands;Maintenance;Mediating;Metabolism;Microbe;microbiota;Modeling;multidisciplinary;Obesity;pathogenic microbe;Persons;Physiological;Play;Population;Process;Proteins;Qualifying;receptor;Receptor Activation;receptor function;response;Risk;Role;Route;Seminal;Series;Signal Transduction;Skin;Source;Tetrachlorodibenzodioxin;theories;therapeutic target;Tissues;Toxic effect;Toxicology;transcription factor;Work

PROJECT_TITLE: Activation of the Ah receptor and epithelial integrity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project narrative Longitudinal, within-subject approaches, have the potential to increase sensitivity and specificity, improving the efficiency of clinical trials by requiring fewer subjects and providing potential surrogate endpoints to assess therapeutic efficacy. Unfortunately, exactly matching all acquisition details across time is difficult if not impossible in the face of software and hardware changes to scanners over time. In this project we seek to develop deep learning techniques that will rapidly and robustly detect subtle anatomical changes that presage cognitive decline in Alzheimer’s Disease and Related Dementias that are accurate for any combination of MRI scanner or acquisition type.

PI_NAMEs: FISCHL, BRUCE  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Accounting;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anatomic Models;Anatomy;Atrophic;Behavior;Cell Death;Clinical;clinical application;clinical imaging;Clinical Research;Clinical Trials;Computer software;Darkness;Data;Data Set;deep learning;deep neural network;design;Detection;Development;Diagnosis;Dimensions;Disease;disease classification;Early Diagnosis;Ensure;follow-up;Generations;Hippocampus;Image;imaging modality;Impaired cognition;improved;Label;Learning;learning network;Left;Lesion;Location;longitudinal analysis;Magnetic Resonance Imaging;Manuals;Maps;Modality;Modernization;Neuroanatomy;Neurologic;neuropathology;Noise;Picture Archiving and Communication System;Positron-Emission Tomography;Predisposition;Procedures;Process;Progressive Disease;Property;Protocols documentation;Research;Scanning;Schedule;Sensitivity and Specificity;Series;Shapes;simulation;Site;Structure;Surrogate Endpoint;synthetic data;Techniques;Technology;Testing;Thalamic structure;Therapeutic Intervention;therapeutically effective;Time;tool;Training;Treatment Efficacy;usability;Validation;Variant;Ventricular

PROJECT_TITLE: Deep Learning for Detecting the Early Anatomical Effects of Alzheimer's Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Integral membrane proteins are the targets of the majority of drugs used in the clinic, yet the mechanism of action for most of these drugs is not fully understood. One reason for this is that most mechanistic studies of membrane proteins extract the protein from its native membrane environment – akin to studying a soluble protein in a dehydrated state. The research proposed by our team will apply new technologies to identify and understand how the native membrane environment impacts membrane protein structure and function, which will inform new strategies to modulate membrane proteins pharmacologically.

PI_NAMEs: BUTTERWICK, JOEL ADAM;FERGUSON, KATHRYN M (contact);GUPTA, KALLOL ;LIU, YANSHENG ;MI, WEI ;SCHLESSINGER, JOSEPH

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Affect;Area;Binding;Biochemical;Biochemistry;Biological Assay;Biophysics;Butyric Acids;Cells;Cellular biology;Chemistry;Clinic;Complex;copolymer;Coupled;Cryoelectron Microscopy;Dehydration;Deuterium;Development;Drug Targeting;Drug usage;Environment;Faculty;Family;G-Protein-Coupled Receptors;Goals;Hydrogen;imaging approach;innovation;Insecta;Integral Membrane Protein;interdisciplinary approach;interest;Ion Channel;Ion Channel Gating;Libraries;Ligands;Lipid Binding;lipidome;lipidomics;Lipids;Lipopolysaccharides;Mass Spectrum Analysis;member;Membrane;Membrane Proteins;Methods;mimetics;Molecular;Molecular Conformation;multiple omics;nanodisk;new technology;novel strategies;olfactory receptor;optical imaging;Outcome;particle;Pharmaceutical Preparations;pharmacologic;Pharmacology;Property;Protein Dynamics;protein function;protein oligomer;protein structure;Proteins;Proteolysis;Proteome;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;reconstitution;recruit;Regulation;Research;Role;Science;screening;sensor;Signal Transduction;single molecule;skills;small molecule;Smell Perception;structural biology;Structure;Technology;Thinking;Water

PROJECT_TITLE: Understanding how membrane composition directs membrane protein structure and function


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative A community-academic team will quantify the impact of a mitigation action plan to reduce air toxics and odors at a landfill in Bristol, Virginia.

PI_NAMEs: HAYNES, ERIN N (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Acrolein;Affect;Air;air monitoring;Air Pollutants;air sampling;Benzene;Breathing;Censuses;Chemicals;Cities;Collaborations;Collection;Communities;community academic partnership;community partners;Country;Detection;Development;Ecological momentary assessment;Effectiveness;Engineering;Ensure;Environmental Health;Environmental Impact;Environmental Policy;Event;experience;Exposure to;Face;Faculty;falls;follow-up;Future;Health;Health Hazards;High temperature of physical object;Home;Hour;Household;Hydrogen Sulfide;improved;Industry;Investigation;landfill;Liquid substance;Location;Low Income Population;Measurement;Measures;meetings;Municipalities;Neighborhoods;Nightmare;Odors;operation;Personal Communication;Pharyngeal structure;pollutant;Poverty;Quality of life;Recommendation;recruit;Reporting;Research;response;sample collection;Sampling;sensor;Solid;Stress;student training;Symptoms;Tennessee;Time;Toluene;toxicant;Toxicology;United States;Universities;Virginia;volatile organic compound;wasting

PROJECT_TITLE: Impact of Landfill Mitigation Efforts to Reduce Air Toxics in Bristol, Tennessee and Virginia


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: Each year 13- to 24-year-olds disproportionately compose the number individuals diagnosed with human immunodeficiency virus (HIV) in the United States. Preexposure prophylaxis (PrEP), a once daily antiretroviral regime, is an effective method to prevent the transmission of HIV in adolescents at substantial risk for acquiring HIV, however, the effect of this regimen on the development of critical brain structures during adolescence is unknown. The proposed experiments will address the gap in knowledge that is the mechanistic basis of the inhibition of oligodendrocyte maturation by antiretrovirals in an HIV-negative, adolescent population.

PI_NAMEs: LONG, CAELA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Anti-Retroviral Agents;Axon;Brain;Cell Culture Techniques;cell type;Cells;Cholesterol;Complex;Data;Development;Diagnosis;Dose;emtricitabine;experimental study;FRAP1 gene;Fumarates;Functional disorder;Future;Gene Expression;HIV;HIV Seronegativity;HIV-associated neurocognitive disorder;Impairment;In Vitro;in vivo;Individual;insight;Knowledge;Link;lipid biosynthesis;Lipids;Lysosomes;Maintenance;Methods;Modeling;Myelin;myelination;Newly Diagnosed;oligodendrocyte progenitor;Oligodendroglia;Osteoclasts;Patients;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevent;Rattus;Regimen;Research;Risk;Role;Signal Transduction;SRE-2 binding protein;Structure;Tenofovir;Therapeutic;Time;transcription factor;transmission process;United States;Viral Load result;white matter;white matter damage

PROJECT_TITLE: Pre-Exposure Prophylaxis (PrEP) inhibits oligodendrocyte differentiation in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Physical Activity;Rehabilitation;Serious Mental Illness

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE Current treatments for depression, including cognitive behavior therapy (CBT) and medication, are not effective for many people, leading to a high global burden of depression. We propose to investigate the effects of a novel intervention approach, intentionally sequencing aerobic exercise immediately prior to CBT sessions to take advantage of the powerful short-term biological and psychological effects of exercise to increase the potency of the psychotherapy (termed ‘ActiveCBT’) using established and cutting-edge techniques to measure both specific and common factors underlying the antidepressant effect of CBT (ie, mechanisms of CBT). This series of studies will determine the potential of this elegant exercise priming approach to enhance key mechanisms of CBT (R61 project) prior to a larger replication of the trial that establishes the effects of ActiveCBT on overall depression outcomes while linking augmented mechanisms in ActiveCBT to better treatment effects (R33 project).

PI_NAMEs: MEYER, JACOB D (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Acute;Adult;Aerobic Exercise;Anhedonia;antidepressant effect;Anxiety;Attention;Behavioral;Biological;Brain-Derived Neurotrophic Factor;Clinical;Cognitive Therapy;Collaborations;confirmatory trial;Data;depressive symptoms;Disease;Effectiveness;Empathy;Exercise;Exercise Therapy;feasibility trial;Fertile Period;Goals;Hamilton Rating Scale for Depression;improved;innovation;Intervention;Investigational Therapies;Ketamine;Link;Machine Learning;Major Depressive Disorder;Measures;meetings;Mental Depression;Mental Health;Modeling;Moderate Exercise;Natural Language Processing;Nature;Neurologic;Neuronal Plasticity;novel;Outcome;Participant;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase;pilot trial;portability;Post-Traumatic Stress Disorders;psychologic;Psychotherapy;Publishing;Randomized;Randomized, Controlled Trials;Relapse;Research;Rest;Series;Signal Transduction;Standardization;success;Techniques;Testing;Time;treatment effect;Treatment Effectiveness;Treatment outcome;treatment strategy;Work

PROJECT_TITLE: ActiveCBT for depression: Transforming treatment through exercise priming


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Center Overview: Project Narrative The Vanderbilt Diabetes Research Center is working to understand why diabetes develops, how it can be prevented, and how diabetes treatment can be improved.

PI_NAMEs: POWERS, ALVIN C (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Area;base;biobank;Biomedical Research;burden of illness;career development;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;Collaborations;college;Communication;Communities;Complications of Diabetes Mellitus;COVID-19 pandemic;Development;Diabetes Mellitus;DNA;Endocrinology;Environment;Etiology;Evolution;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;improved;Individual;Infrastructure;Institution;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;interest;Investments;Knowledge;Link;Medical;medical schools;Medical Students;metabolic phenotype;Metabolism;Mission;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;operation;Osteopathic Medicine;outreach;Patient Care;prevent;Prevention;Productivity;programs;Public Health;recruit;Research;Research Personnel;Resources;Schools;Scientist;Series;Services;skills;student training;synergism;Talents;Training;Training and Education;Translating;Translational Research;translational research program;Translations;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Vanderbilt Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Advisory Committees;American;base;biobank;career development;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;Collaborations;Communication;Communities;community center;Core Facility;Development;Diabetes Mellitus;Digestive System Disorders;DNA;educational atmosphere;Effectiveness;effectiveness evaluation;Environment;equity, diversity, and inclusion;experience;Faculty;Financial Support;Fostering;Funding;General Population;Genetic;Goals;graduate student;Grant;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;Interdisciplinary Study;Interest Group;Leadership;lecturer;lectures;Link;medical schools;Medical Students;meetings;member;Metabolic;metabolic phenotype;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;outreach;Persons;Postdoctoral Fellow;Productivity;programs;Research;Research Personnel;Research Support;Research Training;Resources;Review Committee;Scientist;senior faculty;Series;Source;symposium;Training;Training Activity;Training Programs;Translational Research;undergraduate student;United States National Institutes of Health;Universities;virtual;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not have their children vaccinated when it is recommended at age 11 or 12. In this study, we will examine in a randomized trial whether earlier initiation of the vaccine at age 9-10 years will result in less parental refusal and higher rates of full vaccination at younger ages, before early sexual activity begins.

PI_NAMEs: KEMPE, ALLISON  (contact);SZILAGYI, PETER G

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 10 year old;12 year old;17 year old;9 year old;Academy;Adolescence;Adolescent;Adoption;Advisory Committees;Age;American;arm;Audiotape;California;cancer prevention;cancer therapy;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Clinic;Colorado;Communication;cost;Country;Data;Diagnosis;Disease;effectiveness evaluation;effectiveness outcome;effectiveness testing;experience;Goals;Healthy People 2020;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 11;Immune response;Immunity;Immunization;implementation outcomes;interest;Intervention;Interview;Length;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Morbidity - disease rate;mortality;novel strategies;Observational Study;Odds Ratio;Outcome;Parents;Patients;pediatrician;Pediatrics;Perception;Policies;practice setting;pragmatic randomized trial;pragmatic trial;prevent;Primary Care;primary outcome;Provider;provider communication;Public Health;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research Personnel;Retrospective Studies;Safety;Schedule;screening;secondary outcome;Series;sex;Sex Behavior;Sexuality;Standardization;Structure;Surveys;Teenagers;Time;Training;trial comparing;Vaccinated;Vaccination;vaccine acceptance;vaccine refusal;Vaccines;Visit;working group

PROJECT_TITLE: The HPV9-10 Trial: Early Initiation of HPV Vaccination

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Diabetes;Nutrition

PI_NAMEs: MCGUINNESS, OWEN P (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Address;Amino Acids;Animals;Area;Awareness;Biological;Biological Assay;Biology;C-Peptide;Catecholamines;Clinic;Clinical Immunology;Contract Services;Controlled Environment;cost;Cost Analysis;cytokine;Diabetes Mellitus;Digestive System Disorders;endocrine pancreas development;Epidemiology;Equipment;experience;Experimental Designs;Fatty Acids;Fee-for-Service Plans;Genetic;Genomics;Glucagon;Glucose;Growth;health equity;Hormones;Human;Human Resources;improved;In Vitro;in vivo;Individual;innovation;instrumentation;Insulin;interest;Isoprostanes;Isotopes;Laboratories;Lipids;Lipoproteins;Liquid substance;Mass Fragmentography;Measurement;Measures;Metabolic;metabolic phenotype;Metabolism;method development;Methods;Modernization;Mus;Nucleotides;Obesity;oxidant stress;Oxidative Stress;Pathway interactions;Physiology;Plasma;Postdoctoral Fellow;Procedures;Process;Productivity;programs;Prostaglandins;Protocols documentation;Publications;Reagent;Regulation;Reproducibility;Research;Research Assistant;Research Personnel;Research Project Grants;Resource Sharing;Resources;Running;Sampling;service utilization;Services;Signal Transduction;stable isotope;Standardization;steroid hormone;Students;success;Technology;Tissue Sample;Tissues;Training and Education;Translations;Universities;Wages;Work

PROJECT_TITLE: Analytical Services Core


PI_NAMEs: WASSERMAN, DAVID H (contact)

PROJECT_TERMS: Address;Adipose tissue;Animal Model;Animals;bariatric surgery;Blood Vessels;Cannulations;Catheterization;Cell Communication;Communities;Consult;Data;design;Development;Diabetes Mellitus;Equipment;experience;experimental study;Feedback;flexibility;Funding;Gastrointestinal Surgical Procedures;Genomics;Grant;Human;implantation;in vivo;in vivo Model;Incentives;Indirect Calorimetry;Individual;Infrastructure;intravital microscopy;investigator training;islet;Islets of Langerhans Transplantation;Laboratories;Light;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Pancreas;Participant;Physiological;Physiology;Procedures;programs;Publications;Research;Research Personnel;Research Technics;Resources;Role;Services;skills;Standardization;Strategic Planning;Students;Surveys;Techniques;Technology;Telemetry;Temperature;Time;Training

PROJECT_TITLE: Animal Metabolic Physiology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias are an urgent public health challenge, since no disease-modifying treatments are currently available. The selective vulnerability and resilience of specific neuron types to these diseases can provide important clues for potential therapeutic strategies. The proposed research combines innovative approaches in human tissue as well as human cell-based and mouse models of disease to uncover mechanisms underlying selective vulnerability with the ultimate goal of identifying new therapeutic targets for Alzheimer’s disease and related dementias.

PI_NAMEs: CONDELLO, CARLO L;KAMPMANN, MARTIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease therapy;Automobile Driving;Autopsy;Brain;Brain region;causal variant;Cells;Complement;Complex;CRISPR interference;CUL3 gene;CUL5 gene;Development;differential expression;Disease;disease model;entorhinal cortex;Enzymes;experimental study;Genes;genome-wide;glucose metabolism;Goals;Human;human tissue;In Situ;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;Kinetics;knock-down;member;Metabolism;metabolomics;Methods;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;neuron loss;Neurons;new therapeutic target;Pathogenesis;Pathology;Pathway interactions;Patients;Population;Process;promote resilience;Public Health;Research;resilience;resilience factor;Role;single nucleus RNA-sequencing;small molecule;Stress;tau aggregation;tau Proteins;Tauopathies;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic target;ubiquitin-protein ligase;Validation;Work

PROJECT_TITLE: Molecular mechanisms of selective vulnerability of neurons to tauopathy


PI_NAMEs: BRISSOVA, MARCELA  (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Achyrocline;Aging;analytical tool;Animals;Architecture;Area;bioimaging;Biological Assay;Biology;blood glucose regulation;Cell Differentiation process;cell type;Cells;Cellular Morphology;Complement;Complex;Constitution;cost;Detection;Development;Diabetes Mellitus;Disease;endocrine pancreas development;flexibility;Functional disorder;Funding;Genetic;Histologic;Homeostasis;Hormone secretion;Human;human tissue;Image;Image Analysis;Image Enhancement;imaging modality;Immunology;In Vitro;in vivo;indexing;Individual;Infrastructure;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Location;Maintenance;Measurement;Metabolic;Metabolism;Molecular;Molecular Abnormality;multiplexed imaging;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Pancreas;pancreas development;Phenotype;physiologic stressor;Physiological;Physiology;Procedures;Process;programs;protein expression;Publishing;Radioimmunoassay;Research;Research Personnel;Resolution;Resources;response;Rodent;Services;Signal Transduction;Standardization;success;Techniques;Technology;Tissues;Training;transcription factor;type I and type II diabetes;whole slide imaging;Work

PROJECT_TITLE: Islet and Pancreas Analysis Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE – OVERALL COMPONENT Drug abuse, including tobacco, causes hundreds of thousands of premature deaths annually in the US, and is responsible for much human suffering. The research projects that our P30 Center supports seek to reduce this human toll, by understanding the factors that cause drug addiction, in order to develop more effective treatments and prevention programs. Since smoking tobacco, cannabis, and other drugs produces toxic substances, measuring human exposure to them is necessary to assess health risks, which we do using biomarkers, for people or human subjects using these drugs, and for some studies for people exposed to secondhand or thirdhand smoke, in order to guide public policy and reduce exposure.

PI_NAMEs: JACOB, PEYTON  (contact);JONES, REESE T.

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: addiction;Analytical Chemistry;analytical method;Applications Grants;Biological Markers;Cannabis;Cardiology;career;career development;Cessation of life;Chemistry;Clinic;Clinical Research;cost;cost effective;Country;Data Analyses;Dentistry;design;Development;Discipline;Drug abuse;Drug Addiction;Drug Kinetics;drug of abuse;Drug usage;effective therapy;environmental tobacco smoke exposure;experience;exposed human population;Exposure to;Faculty;Funding;Future;Goals;Grant;Harm Reduction;Health;health assessment;Human;human subject;improved;Individual;Infrastructure;Institution;Institutional Review Boards;instrument;Internal Medicine;Laboratories;Learning;Manuscripts;Measures;member;Mentors;method development;Methods;Modality;National Institute of Drug Abuse;Occupational Medicine;Pediatrics;Persons;Pharmaceutical Preparations;Pharmacology Study;Pharmacotherapy;Pilot Projects;Poison;Postdoctoral Fellow;premature;Preparation;Prevention;Prevention program;programs;Psychiatry;Psychology;Psychotropic Drugs;Public Health;public health research;Public Policy;Pulmonology;Request for Applications;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resources;response;Risk;Services;skills;Smoking;Substance abuse problem;synergism;thirdhand smoke;Tobacco;Tobacco Dependence;tobacco products;Toxicology;treatment program;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: Drug Dependence Clinical Research Program


PROJECT_TERMS: Animals;Cannulas;Catheters;Clinic;Closure by clamp;Communities;Complex;Consult;Cost Savings;CRISPR/Cas technology;Decision Making;Dedications;Development;Diabetes Mellitus;Diabetic mouse;Disease;Education;Exercise;experience;Faculty;flexibility;Funding;Future;Gene Modified;Genetic Models;Genetic Polymorphism;Grant;Human;Human Genetics;implantation;in vivo;Individual;Infrastructure;Institution;Leadership;Link;Metabolic;metabolic abnormality assessment;Metabolic Control;Metabolic Diseases;metabolic phenotype;Metabolism;Mission;Modification;mouse genetics;mouse genome;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Operative Surgical Procedures;Paper;Participant;Physiology;Play;Procedures;Production;programs;Radioisotopes;Research;Research Personnel;Research Proposals;Resources;response;Risk;Role;Scientist;Services;skills;stable isotope;Standardization;Strategic Planning;success;Surgeon;Surveys;Techniques;Technology;Time;tool;Training;Variant

PROJECT_TITLE: Mouse Diabetes Clinic at Vanderbilt


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PI_NAMEs: JACOB, PEYTON  (contact)

PROJECT_TERMS: addiction;Analytical Chemistry;Applications Grants;Area;Biological Markers;Clinical Research;Collaborations;Computers;Consult;Data Analyses;Data Reporting;Drug abuse;Drug Addiction;Drug usage;experience;Funding;Grant;Health;Human;human subject;Infrastructure;Institutional Review Boards;Laboratories;Link;Manuscripts;Measures;Mentors;Persons;Pharmaceutical Preparations;Pilot Projects;Preparation;programs;Psychotropic Drugs;Request for Applications;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;Services;Source;Telephone;Training;United States National Institutes of Health


PROJECT_TERMS: addiction;Analytical Chemistry;analytical method;Biological Markers;biomarker development;Clinical Research;Collaborations;cost effective;Country;Development;Drug abuse;Drug Addiction;Drug usage;experience;Funding;Future;Grant;Health;Human;Infrastructure;Institution;instrument;Laboratories;Measures;method development;Methods;Pharmaceutical Preparations;Pilot Projects;programs;Psychotropic Drugs;Request for Applications;Research;Research Personnel;Research Priority;Research Support;Resources;Source;United States National Institutes of Health

PROJECT_TITLE: Research Support Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: ST.HELEN, GIDEON  (contact)

PROJECT_TERMS: addiction;Analytical Chemistry;Biochemical;Biological Markers;career;Clinical Research;Clinical Trials Network;Consultations;Data Analyses;Drug abuse;Drug Addiction;Drug usage;ethnic minority;Ethnic Origin;experience;Faculty;Funding;Funding Agency;Funding Mechanisms;Funding Opportunities;Goals;Grant;Human;human subject;innovation;Institutional Review Boards;Intramural Research;Learning;marijuana use;Measures;National Institute of Drug Abuse;Pharmaceutical Preparations;Pilot Projects;Postdoctoral Fellow;Prevention;Prevention Research;professor;programs;Progress Reports;racial minority;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resource Allocation;Resources;response;sample collection;Scientist;Services;skills;Students;Substance abuse problem;substance use;Tobacco use;Training Programs;Training Support;United States;United States National Institutes of Health;Universities;volunteer

PROJECT_TITLE: Pilot Research Project Core


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: STEIN, ROLAND W (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;American;Award;Awareness;Behavioral Research;biobank;Biochemistry;Biomedical Research;Biophysics;Cardiovascular system;career;career development;Categories;Clinical and Translational Science Awards;clinical center;Clinical Data;clinical investigation;Clinical Research;Communities;Core Facility;Critiques;Data;Diabetes Mellitus;Digestive System Disorders;Direct Costs;Discipline;DNA;Effectiveness;Endocrinology;Engineering;epidemiology study;Extramural Activities;Faculty;Funding;Funding Mechanisms;Goals;Grant;Health Services Research;Individual;Infrastructure;innovation;Institution;Insulin-Dependent Diabetes Mellitus;Laboratories;Leadership;Link;Lung;Measures;Medicine;member;Molecular;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Ophthalmology;Peer Review Grants;Physiology;Pilot Projects;Program Reviews;programs;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Review Committee;Rheumatology;Study Section;success;Time;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Program


PI_NAMEs: STAFFORD, JOHN MICHAEL (contact)

PROJECT_TERMS: Abbreviations;Area;career;Career Choice;career development;Country;Coupling;COVID-19;COVID-19 pandemic;Databases;Diabetes Mellitus;E-learning;Education;Educational Curriculum;Ethnic Origin;experience;Exposure to;Faculty;flexibility;follow-up;Fostering;Funding;Future;Geography;Goals;Grant;Hybrids;improved;innovation;Lead;lectures;Medical;medical schools;Medical Students;Mentors;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;novel strategies;Obesity;Outcome;outreach;Participant;Persons;Phase;Physicians;Process;professor;Program Evaluation;programs;Puerto Rico;recruit;Research;research and development;Research Personnel;Research Project Grants;response;Scientist;Series;skills;Student Selections;Students;success;summer program;summer research;symposium;synergism;System;Time;tool;Training;Training Programs;virtual;Visit;Work

PROJECT_TITLE: NIDDK Medical Student Research Program