ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis;Wound Healing and Care

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE In humans, the outcome of wound healing is often formation of a fibrous scar, which can severely impair the function of the repaired tissue or organ. This proposal will examine how microfibril-associated protein 5 (MFAP5) modifies the fibroblast response in wound repair to promote fibrous scar formation. The proposed studies will lead to a better understanding of the mechanisms by which microfibril-associated proteins and apoptotic cells influence fibroblast function as well as wound healing outcomes and may suggest the development of novel therapeutics to treat fibrotic diseases.

PI_NAMEs: HAN, CHEN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Adult;Affect;angiogenesis;Apoptotic;Architecture;Area;Bioinformatics;Biological Assay;Body System;career development;cell motility;Cells;Chemoresistance;Cicatrix;Collagen;comparison control;Complex;Contracture;Data;design;Development;differential expression;Disease;Esthetics;experimental study;extracellular;Extracellular Matrix;fibrillin;Fibroblasts;Fibrosis;Gene Expression;Genes;Genomics;Goals;healing;Hemostatic function;Human;human disease;Hypertrophic Cicatrix;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Ingestion;Institution;Keloid;Knockout Mice;laboratory experiment;Lead;Link;Liver Cirrhosis;Malignant Neoplasms;Mediator;MFAP1 gene;Microfibrils;migration;Mus;Myocardial Infarction;Myofibroblast;novel;novel therapeutics;Ontology;Organ;Outcome;overexpression;Pain;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Patients;Phagocytes;Phase;Phenotype;Process;Production;Prognostic Marker;Proliferating;Proteins;Pulmonary Fibrosis;recruit;Regulation;repair function;Research;Research Personnel;Research Training;Resources;response;RNA;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin fibrosis;skin healing;Skin wound healing;Source;Surface;Systemic Scleroderma;targeted biomarker;Techniques;therapeutic biomarker;tissue injury;tissue repair;Tissues;Training;transcriptome;transcriptome sequencing;Transfection;Up-Regulation;vector;Width;Work;wound;wound closure;wound healing

PROJECT_TITLE: MFAP5 and Skin Scar Formation


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  There are currently no therapies to restore mobility and sensation following spinal cord injury or vision after optic nerve damage. We will combine single-cell approaches and epigenomic approaches in mouse and human sensory neurons to understand the neuronal and non-neuronal mechanisms orchestrating nerve repair. We propose a multifaceted research program that may lead towards novel strategies to increase the extent of axon regeneration, which may improve recovery after nervous system injuries.

PI_NAMEs: CAVALLI, VALERIA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affect;Afferent Neurons;Automobile Driving;Axon;axon growth;axon injury;axon regeneration;Biological Models;cell type;Cells;Central Nervous System;central nervous system injury;Chromatin;Environment;Epigenetic Process;epigenomics;Esthesia;Failure;Future;Genes;Genetic Transcription;Goals;Human;improved;Individual;injured;innovation;Lead;Lifelong disability;Molecular Conformation;Molecular Profiling;mouse model;Mus;Natural regeneration;nerve damage;nerve repair;Nervous System Trauma;Neurobiology;Neuroglia;neuronal cell body;Neurons;novel;novel strategies;Optic Nerve;Optic Nerve Injuries;Pathway interactions;Peripheral;Physiology;Process;programs;Recovery;regenerative;Regenerative capacity;Regulation;repaired;Research;Sensory Ganglia;Site;Spinal cord injury;success;tool;Vision

PROJECT_TITLE: Multicellular Mechanisms Driving Axon Regeneration


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Bulk-tissue RNA-seq datasets are now available in tens-of-thousands of samples, often coupled with potentially highly informative phenotypic data and other -omics data, such as that collected in electronic medical records or by NIH initiatives such as the Genotype-Tissue Expression (GTEx) project. However, current computational tools are insufficient for interrogating this bulk-tissue RNA-seq data at the level of the constituent cell-types, which has been shown to obscure biological mechanisms and insights. We propose developing computational tools that will allow us to interrogate large bulk-tissue RNA-seq at the cell-type level, by leveraging small reference single- cell RNA-seq datasets generated on the same tissue type—we will also expand these computational methodologies for the analysis of emerging spatial transcriptomics platforms.

PI_NAMEs: GEELEHER, PAUL  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Award;Bar Codes;Biological;Blood Cells;Breast Cancer Risk Factor;Cell Separation;cell type;Cells;clinical phenotype;Computerized Medical Record;computerized tools;Computing Methodologies;cost;Coupled;Data;Data Set;data tools;differential expression;Disease;Dissociation;Emerging Technologies;Ethnic Origin;experimental study;Gene Expression;Gene set enrichment analysis;Genetic;Genetic Variation;Genotype;Genotype-Tissue Expression Project;Human;Immune response;In Situ;Individual;Inherited;insight;Mammary Neoplasms;Mathematics;Measures;Methods;miniaturize;Molecular;Molecular Biology;novel;Outcome;Pharmacotherapy;Phenotype;phenotypic data;programs;Protocols documentation;Research;Resolution;risk variant;Sample Size;Sampling;sex;Sex Differences;single-cell RNA sequencing;Spottings;Techniques;The Cancer Genome Atlas;Tissue Sample;Tissue-Specific Gene Expression;Tissues;tool;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Whole Blood

PROJECT_TITLE: Computational tools for estimating cell-type-specific effects in bulk RNA-seq and spatial transcriptomics data, using reference single-cell RNA-seq datasets

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Infectious Diseases;Lupus;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative This project as moved from suspecting there were genes contributing to lupus three decades ago to the present point where we have a strong infectious cause and nearly 200 genes. This project will determine whether the proposed infectious cause of systemic lupus erythematosus (SLE), the Epstein-Barr virus that also causes most mononucleosis, works together with the genetic changes to participate in processes that have the plausible potential to cause SLE.

PI_NAMEs: KOTTYAN, LEAH CLAIRE (contact);WEIRAUCH, MATTHEW TYSON

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Alleles;Antibodies;Antibody Response;antigen processing;Antigens;Antinuclear Antibodies;Attention;B-Lymphocytes;Behavior;Binding;causal variant;CD8-Positive T-Lymphocytes;cell transformation;cell type;Cells;Childhood;ChIP-seq;cofactor;Complex;Data;Data Set;Dedications;Disease;disorder risk;DNA Binding;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus Nuclear Antigens;Etiology;exhaustion;experimental study;Foundations;Frequencies;Gene Expression;Gene Expression Regulation;gene product;Genes;Genetic;genetic linkage;Genetic Risk;Genetic Transcription;Genome;genomic locus;Genomic Segment;Genomics;Human;Human Herpesvirus 4;Immune response;infected B cell;Infectious Mononucleosis;Knowledge;Location;Lupus;Major Depressive Disorder;Methods;Mutation;Neighborhoods;Nuclear Antigens;Patients;Process;programs;Progress Reports;Publications;Publishing;Reagent;Regulation;Risk;risk variant;Role;Screening procedure;Specificity;Systemic Lupus Erythematosus;Systems Biology;Technology;Testing;transcription factor;transforming virus;Variant;Viral Load result;virtual;Work

PROJECT_TITLE: Genetic Linkage in Lupus

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This training program is designed to address the significant and costly public health problem of substance use disorders by training postdoctoral biomedical, biobehavioral, health care, and other public health scientists to conduct addiction intervention research. Our program draws on many scientific disciplines, including biological sciences, epidemiology and etiology, prevention, clinical, and public health research, and emphasizes multidisciplinary approaches to achieving innovations in addiction research. Cutting-edge training of the next generation of addiction researchers has the potential to accelerate the pace of science in developing effective treatments.

PI_NAMEs: ROHSENOW, DAMARIS J.;TIDEY, JENNIFER W. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Intervention;Outcomes Research;Research Training;Substance abuse problem

PROJECT_TITLE: Substance Abuse Intervention Outcome Research Training

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Public Health Relevance The mechanisms that bacteria use to regulate gene expression are crucial for their ability to grow and adapt in different environments. The goal of my lab is to establish an essential framework for understanding bacterial gene regulation by uncovering how transcription, translation, and mRNA degradation are performed and regulated inside a single bacterial cell. This work will suggest new ways to control gene expression in bacteria— an ability that has potential applications to human health issues, such as promoting healthy microbiomes, killing pathogens, and improving industrial processes to reduce pollution.

PI_NAMEs: KIM, SANGJIN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Age;Bacteria;Bacterial Genes;bacterial genetics;Birth;Cell Nucleus;Cells;Cessation of life;Coupling;Cytoplasm;DNA-Directed RNA Polymerase;Ecosystem;Environment;Escherichia coli;Foundations;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Health;Heterogeneity;Human;Image;improved;Industrialization;Measures;Messenger RNA;Methods;microbiome;Modeling;mRNA Transcript Degradation;pathogen;Physiological;Play;Pollution;Process;Production;programs;Proteins;public health relevance;Research;ribonuclease E;Ribonucleases;Ribosomal Interaction;Ribosomes;Role;single molecule;spatiotemporal;Techniques;Translations;Work

PROJECT_TITLE: Single-molecule analysis of how birth and death of mRNAs are regulated inside a bacterial cell

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Orphan Drug;Rare Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative  Flavivirus lead to recurrent epidemic outbreaks and are a global threat to human health without any effective antiviral treatment. This project will develop and deploy a novel nanopore tweezers approach that can provide a complete conformational dynamics, binding thermodynamics and kinetics profile of the flaviviral protease to guide the discovery and design of new inhibitors. The nanopore tweezers platform, operating independent of the enzyme activity, will also provide a new paradigm for label-free, single molecule and high-throughput drug screening.

PI_NAMEs: CHEN, MIN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Active Sites;Affinity;Allosteric Site;anomer;Anti-viral Agents;Anti-viral Therapy;Binding;Biochemical;Biological Assay;Biological Availability;biophysical model;Biophysics;Charge;Clinical;Complex;Computer Models;Cryoelectron Microscopy;cryptography;Cytolysins;Data;Dengue;Dengue Infection;Dengue Virus;Dengvaxia;design;design and construction;Disease Outbreaks;drug development;drug discovery;drug efficacy;Drug Interactions;Drug Targeting;enzyme activity;Epidemic;Equilibrium;experience;experimental study;Flavivirus;Foundations;guided inquiry;Health;high throughput screening;high-throughput drug screening;Human;improved;in vivo;Infection;inhibitor;innovation;insight;Investigational Drugs;Kinetics;Label;Lead;Libraries;maltose-binding protein;Measurement;Measures;Methods;Molecular;Molecular Conformation;molecular modeling;Monitor;mosquito-borne pathogen;Motion;nanopore;Nature;novel;Peptide Hydrolases;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Property;Protein Dynamics;Protein Engineering;Proteins;rational design;Reaction;Recurrence;residence;Resolution;Roentgen Rays;screening;Serine Protease;Serotyping;Signal Transduction;simulation;single molecule;Substrate Cycling;Substrate Interaction;sugar;System;Techniques;Technology;Testing;Thermodynamics;Time;tool;Vaccines;Viral;Viral Proteins;Virus Replication;West Nile viral infection;West Nile virus;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Probing Functional States and Inhibition of Flaviviral Proteases Using Nanopore Tweezers

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: NARRATIVE We propose to characterize the mechanisms underlying the SECH approach for the eradication of HIV-1 infections in macrophage lineage, through the combination of viral reactivation with induction of apoptosis and inhibition of autophagy. We aim to improve the efficacy of SECH approach in clearing latent HIV-1 infections in lymphoid organs and in the brain.

PI_NAMEs: WANG, JIN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Apoptosis;Apoptotic;Autophagocytosis;Blood specimen;Brain;CD4 Positive T Lymphocytes;Cell Death;Cells;chronic infection;cytokine;Data;Development;DNA;Ensure;experimental study;HIV;HIV Infections;HIV-1;Human;humanized mouse;Immune system;Immunologic Memory;improved;In Vitro;in vivo;Induction of Apoptosis;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;insight;lymphoid organ;Macrophage;Memory;Microglia;Mus;Myelogenous;Myeloid Cells;novel;Patients;Pharmaceutical Preparations;preservation;reconstitution;Regimen;Resistance;Reverse Transcription;Safety;Specificity;success;T memory cell;T-Lymphocyte;Testing;Tissues;Viral;Virus;Work

PROJECT_TITLE: Targeting the HIV-1 Reservoir in Myeloid Cells


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Dementia with Lewy bodies (DLB) is one of the most common neurodegenerative dementias after Alzheimer disease (AD). The proposed study will provide novel insight into the pathophysiological brain changes in individuals with DLB, compared to AD and healthy older adults, using diffusion-weighted MRI (dMRI) and task- based high-density electroencephalography (EEG). This research has the potential to inform future development of dMRI and EEG as potential biomarkers for DLB, to examine longitudinal progression of disease, and determine whether therapeutic interventions are having expected effect(s) on brain microstructure and cortical activity.

PI_NAMEs: CHIU, SHANNON  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: accurate diagnosis;Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Autopsy;Biological Markers;Biometry;Brain;Brain imaging;career;career development;Centers of Research Excellence;Clinical;clinical biomarkers;Clinical Research;clinically relevant;Cognitive;cohort;Collaborations;Collection;Data;Dementia with Lewy Bodies;density;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Electroencephalography;Enrollment;Environment;Equipment and Supplies;Event;experience;Florida;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;grasp;gray matter;Image;imaging approach;Impairment;improved;in vivo;Individual;Inferior;Inflammation;insight;Institution;Laboratories;Leadership;Learning;Lewy Body Dementia;Lewy Body Disease;Lewy body pathology;Link;Literature;Long-Term Care;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Measures;Medial;medial temporal lobe;Mentors;Methods;Modality;Monitor;Motor;mouse model;multi-ethnic;multi-racial;Nerve Degeneration;neural;neurodegenerative dementia;Neurons;neurophysiology;novel;older adult;Parietal;Parietal Lobe;Parkinsonian Disorders;Participant;Pathology;Pathway interactions;Patients;Pattern;potential biomarker;preservation;Process;Prognosis;prospective;putamen;REM Sleep;Research;Research Design;Research Personnel;responsible research conduct;secondary outcome;Sensitivity and Specificity;Site;sleep behavior;structural imaging;Structure;Substantia nigra structure;symposium;Symptoms;Techniques;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;Training;Training Programs;United States National Institutes of Health;Universities;Update;visual feedback;Visual Hallucination;Water;water diffusion;white matter

PROJECT_TITLE: Neurodegeneration and Neuronal Fluctuations in DLB and AD

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Understanding how and why antisocial behavior (e.g., aggression, rule breaking) develops in the context of disadvantage is of critical importance to promoting health in adolescents and decreasing societal costs related to these disruptive behaviors. The proposed project will use longitudinal methods to examine whether socioeconomic disadvantage increases risk of engagement in antisocial behavior via reward-related brain structure and function. Results will inform reward-related interventions for adolescents at most risk for deleterious outcomes due to exposure to disadvantage.

PI_NAMEs: WESTERMAN, HEIDI BETH (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 21 year old;Address;Adolescence;Adolescent;Adult;Affective;affective neuroscience;African American;Age;Aggressive behavior;antisocial behavior;Anxiety;Architecture;Behavior;Biological;biopsychosocial;Birth;Brain;career;Child Welfare;Childhood;Clinical;cognitive control;Cohort Studies;Communities;Conduct Disorder;Corpus striatum structure;cost;Data Analyses;Development;Disadvantaged;emerging adult;Emotions;Environment;Exposure to;Family;Fellowship;Goals;gray matter;Health Promotion;Human;Imprisonment;Income;insight;Intervention;Lifestyle-related condition;Link;Low income;Low Income Population;Manuscripts;Measures;Mental Depression;Mental disorders;Mentorship;Methodology;Methods;Michigan;Motivation;multimodal neuroimaging;neural;neural correlate;neurobiological mechanism;neurodevelopment;neuroimaging;neuromechanism;Neurophysiology - biologic function;Nucleus Accumbens;Outcome;perpetrators;Play;Poverty;Prevention;Process;Psychiatric Diagnosis;Psychopathology;Publications;putamen;Recording of previous events;Research;Research Project Grants;reward anticipation;reward processing;Rewards;Risk;Risk Factors;Role;Sampling;Shapes;skills;social;societal costs;Societies;socioeconomic adversity;socioeconomic disadvantage;Statistical Models;Stress;Structure;Substance Use Disorder;Support System;System;Testing;Training;Universities;urban setting;Ventral Striatum;young adult;Youth

PROJECT_TITLE: Childhood Socioeconomic Disadvantage and Antisocial Behavior: Investigating the Role of Reward Processing


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH Using novel mouse models and imaging approaches, this project seeks to understand how activity of CCR2 signaling proteins regulates the progression of noninvasive breast cancers to invasive breast cancers by altering cellular metabolism. Through this project, we may identify new strategies to predict the development of invasive breast cancer and contribute to more effective strategies to treat breast cancer.

PI_NAMEs: CHENG, NIKKI  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Animal Model;Animals;Biochemical;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;breast cancer diagnosis;breast cancer survival;breast lesion;Cancer Cell Growth;cancer invasiveness;Carcinoma;CCL2 gene;Cell Culture Techniques;cell growth;Cells;cellular imaging;chemokine;chemokine receptor;Chemotaxis;Degradation Pathway;Development;Diagnosis;Disease Progression;Enzymes;experience;FASN gene;Fatty Acids;Fatty-acid synthase;G-Protein-Coupled Receptors;Glucose;Glutaminase;Glutamine;Glycolysis;Goals;Growth;Hexokinase 2;imaging approach;Impairment;In Vitro;infiltrating duct carcinoma;Inflammation;Injections;Invaded;Invasive Lesion;knock-down;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolomics;Modeling;Molecular;monocyte chemoattractant protein 1 receptor;Motility;mouse model;Noninfiltrating Intraductal Carcinoma;novel;overexpression;overtreatment;Pathway interactions;patient prognosis;Patients;Pattern;personalized approach;pharmacologic;predictive marker;protein degradation;protein expression;Proteins;Public Health;Receptor Protein-Tyrosine Kinases;recruit;Recurrent disease;response;risk prediction;Role;Sampling;Signal Transduction;Signaling Protein;Spectrum Analysis;therapeutic target;Tissues;transplant model;tumor metabolism;tumor progression;Tumor Tissue;women's diagnosis;wound closure

PROJECT_TITLE: Progression of DCIS to Invasive Breast Cancer through CCR2 Chemokine Signaling

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative  Current understanding of the development and function of the peripheral nervous system is almost entirely neuron-centric and little attention has been given to the important contributions of glial cell types. This proposal aims to rectify this gap in knowledge by investigating a glial population in the developing heart that actively modulates cardiac function. A better understanding of glia supports a more complete model of neural control over peripheral physiology and pathology.

PI_NAMEs: LIGHT, SARAH ELISABETH WILLIAMS (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Ablation;Agonist;Animal Model;Animals;Arrhythmia;Astrocytes;Attention;Behavior;Biological Sciences;Blood flow;Brain;calcium indicator;Cardiac;Cardiac Myocytes;cardiogenesis;cell type;Cells;Cellular Morphology;Central Nervous System;Characteristics;Communication;Complex;congenital heart abnormality;Development;Educational process of instructing;Enteric Nervous System;Environment;experimental study;Fertilization;Functional disorder;Future;Gap Junctions;Goals;Growth;Health;Heart;Heart Diseases;heart function;Heart Rate;heart rhythm;Homeostasis;Human body;Image;imaging facilities;Immunohistochemistry;in vivo;insight;Institution;Kidney;Knock-out;Knowledge;Laboratories;Light;Lung;Mentors;Microscopy;migration;Modeling;Molecular Profiling;Monitor;Morphology;Nervous System control;Nervous System Physiology;neural;neural model;Neuroglia;neuronal circuitry;Neurons;neuroregulation;novel;Optics;Organ;organ growth;Organogenesis;Pancreas;Pathology;Pattern;Peripheral;Peripheral Nervous System;Physiological;Physiology;Play;Population;Population Dynamics;Process;Reflex action;Regulation;Research;Resolution;response;Role;Running;Signal Pathway;Signal Transduction;skills;Skin;Spleen;Stimulus;Structure;success;System;Technical Expertise;Time;tissue fixing;Transgenic Animals;undergraduate student;Universities;Ventricular Fibrillation;Work;Zebrafish

PROJECT_TITLE: Investigating the Critical Role of Glia In Peripheral Organ Development and Physiology


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Viral assembly is a tightly regulated process driven by a series of conformational changes and interactions between viral proteins. The proposed research is relevant to human health because the portal protein is essential for the formation of infectious dsDNA viruses, including herpes and adenoviruses, making it a viable drug target. This work will use bacteriophage P22, a paradigm for dsDNA viral assembly, to investigate, in detail, how the portal protein is involved in infectious virus production to aid the development of novel anti-viral therapeutics.

PI_NAMEs: LEROUX, MAKAYLA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adenoviruses;Affect;Anti-viral Agents;Bacteriophage P22;Bacteriophages;Binding;Binding Proteins;Biochemistry;Biological Assay;Capsid Proteins;Cells;Charge;Complex;Cryoelectron Microscopy;Data;Development;DNA;DNA Packaging;Double Stranded DNA Virus;drug development;Drug Targeting;ds-DNA;experimental study;Fluorescence;Genetic;Genome;Goals;Head;Health;Herpesviridae;Human;human pathogen;in vivo;innovation;Light;Methods;Modeling;Molecular Conformation;monomer;Morphology;Mutate;novel;Pathway interactions;Potassium;Process;Production;protein complex;protein protein interaction;Proteins;Research;Resolution;Role;Salmonella typhimurium;Scaffolding Protein;Series;Signal Transduction;Site;Structure;System;Tail;Techniques;terminase;Testing;Time;Transmission Electron Microscopy;Variant;Viral;Viral Proteins;Virion;Virus;Virus Assembly;Wing;Work

PROJECT_TITLE: Investigating the conformational changes of the portal protein that drive DNA packaging in a dsDNA virus


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Sleep Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative The purpose of this study is to examine the relationships between routine nursing care, stress, and sleep in preterm infants. Stress exposure and disrupted sleep behavior early in life may lead to poor long-term outcomes. The findings will help identify areas to improve care to support healthy development.

PI_NAMEs: CISTONE, NICOLE  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;adverse outcome;Affect;African American;Area;Behavior;Behavioral;biological adaptation to stress;biological sex;Black race;Brain;care delivery;Care given by nurses;care giving burden;career;caregiving;Caring;Child Development;Circadian Rhythms;Clinical;Cognitive;critical period;design;Development;Developmental Delay Disorders;Diagnosis;Disparity;Distress;electronic health data;Electronic Health Record;Energy Metabolism;Event;experience;Exposure to;Face;forging;Foundations;Galvanic Skin Response;Gestational Age;Grant;Health;health equity;health inequalities;Health Promotion;Hormonal;Hospitalization;Hour;Hydrocortisone;Hypothalamic structure;improved;Infant;Infant Behavior;Interruption;Intervention;Knowledge acquisition;knowledge integration;Life;Link;male;Measures;Modeling;Morbidity - disease rate;Motor;National Institute of Nursing Research;Neonatal;Neonatal Intensive Care;Neonatal Intensive Care Units;neurodevelopment;neurophysiology;neurosensory;Nociception;Nurses;Observational Study;Outcome;Pain;Personal Satisfaction;Physiological;Pituitary-Adrenal System;Play;pre-doctoral;Premature Infant;prevent;Prevention;psychologic;Race;racial difference;Recording of previous events;Research;Research Assistant;Research Methodology;Research Personnel;response;Risk;Risk Factors;Role;Salivary;Schedule;Severity of illness;sex;skills;Sleep;sleep behavior;Sleep disturbances;Solid;Stimulus;Strategic Planning;Stress;stress state;stressor;Synapses;System;Tactile;Training

PROJECT_TITLE: Stress Response of Preterm Infants to NICU Caregiving

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Delivery room (DR) resuscitation is paramount to the survival of extremely premature neonates, yet there is significant variation in DR practices and outcomes within the US. This variation highlights the need for improved and consistent care, but there are no comprehensive approaches to assess DR care and no validated DR quality metrics to help explain and rectify this variation. This proposal seeks to (1) define and validate DR quality metrics and (2) develop comprehensive DR models to identify systematic factors that impact quality that can be used to develop, predict, model, and evaluate future interventional studies aimed at decreasing variation and improving neonatal outcomes.

PI_NAMEs: HERRICK, HEIDI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Leveraging Human Factors to Evaluate Quality of Neonatal Delivery Room Care

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Early detection of viruses replicating within cells leading to the production of interferon is crucial for immune activation to limit further viral replication and spread. Using a combination of cellular and biochemical assays and murine infection models, we will dissect the mechanism by which HOIL1, a ubiquitin ligase and component of the Linear Ubiquitin Chain Assembly Complex, differentially regulates the production of interferon through the RIG-I Like Receptor signaling pathways during infection with distinct viral species. We expect our findings will aid in the identification of novel therapeutic strategies to treat viral infections and interferon-mediated inflammatory diseases.

PI_NAMEs: MACDUFF, DONNA A (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Adaptor Signaling Protein;Antibiotics;Autoimmune Diseases;Autoimmunity;Biochemical;Biological;Biological Assay;Biological Response Modifiers;Biotin;Calicivirus;Catalytic Domain;cell type;Cells;Chronic;chronic infection;Complex;conditional knockout;Coupled;cytokine;Data;Dendritic Cells;Development;Disease;Early Diagnosis;Environment;Epithelial Cells;Event;Exhibits;Family;Family Picornaviridae;Feces;Fibroblasts;Genes;Genetic Complementation Test;Genetic Transcription;Goals;gut microbiota;Health;Human;immune activation;Immune response;Immune system;Immunity;Immunoprecipitation;in vivo;Induced Mutation;Infection;Inflammation;Inflammatory;Integration Host Factors;Interferon Activation;Interferons;intestinal epithelium;Knock-in Mouse;Knock-out;Knockout Mice;Label;Location;Macrophage;Mass Spectrum Analysis;Maus Elberfeld virus;Measures;Mediating;Mitochondria;Modeling;Monitor;Morbidity - disease rate;Mus;mutant;Mutate;Mutation Analysis;new therapeutic target;Norovirus;novel;novel therapeutic intervention;pathogenic virus;Pathology;Pathway interactions;Prevention;Production;protein complex;Proteins;Receptor Signaling;recruit;Regulation;Research;response;RNA;RNA Viruses;Role;Sendai virus;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Structure;Tertiary Protein Structure;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;TMEV;Transcriptional Activation;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Vaccines;Vesicular stomatitis Indiana virus;Viral;viral detection;Viral Load result;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;Virus Replication;Western Blotting

PROJECT_TITLE: Defining the differential roles of HOIL1 and the Linear Ubiquitin Chain Assembly Complex in interferon induction by MDA5 and RIG-I during viral infection.

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Digestive Diseases;Microbiome

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Commensal microbes play crucial roles in human health and disease, and particularly in modulation of mucosal immune responses, however, the underlying mechanisms are poorly understood. We have identified a novel role for intestinal epithelial cells in transporting proteins from commensal microbes for induction of a protective anti-inflammatory Th17 cell response. Here we will investigate the role of IECs and commensal Th17 cells in mucosal homeostasis.

PI_NAMEs: IVANOV, IVAYLO IVANOV (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Antigen Presentation;antigen processing;Antigens;Automobile Driving;Bacteria;Carrier Proteins;CD4 Positive T Lymphocytes;Cell Physiology;Cells;commensal microbes;Complex;cytokine;Data;Development;Disease;Endocytosis;Epithelial Cells;Epithelium;Exocytosis;experimental study;factor C;Fostering;Generations;gut inflammation;Health;Homeostasis;Human;Immune;Immune system;Immunology;immunoreaction;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interleukin-10;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;Maintenance;Microbe;microbial;Mucosal Immune Responses;Mucosal Immunity;mucosal site;mucosal vaccine;Mucous Membrane;Mus;Nature;novel;pathogen;Pathway interactions;Peptides;Phenotype;Play;prevent;Process;programs;Reaction;receptor;Regulation;response;Role;Sampling;sensor;Side;Sterility;Symbiosis;T cell response;T-Lymphocyte;Testing;Tissues;transcription factor;transcytosis

PROJECT_TITLE: Maintenance of mucosal homeostasis by commensal Th17 cells


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Nearly all cellular processes are influenced by small RNAs and their dysregulation has been implicated in fertility defects and disease. This study uses genetics and genomics to advance our understanding of how small RNAs control gene expression in the germline. The results will uncover new roles for small RNAs and mechanisms underlying small RNA function that preserve fertility and health from one generation to the next.

PI_NAMEs: MONTGOMERY, TAIOWA AKONI (contact)

PROJECT_TERMS: Address;Affect;Animals;Area;Biological Assay;Caenorhabditis elegans;Cell Physiology;Deposition;Development;Disease;DNA;Elements;Embryo;Ensure;Essential Genes;Fertility;Fertility Disorders;fertility preservation;fly;Functional disorder;Gene Expression;Gene Silencing;Generations;Genes;Genetic;genome editing;Genomics;Germ Lines;Health;Heritability;Human;Knowledge;Length;Malignant Neoplasms;Messenger RNA;MicroRNAs;Molecular;Nematoda;Nucleotides;Pathway interactions;piRNA;Process;Proteins;Reporting;Research;RNA;RNA Interference;Role;sensor;Small Interfering RNA;Small RNA;Sterility;Structure;System;Transcript;Translational Repression;transmission process

PROJECT_TITLE: Mechanism and function of small RNAs in development and gene silencing in the germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Natural Products;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The current study will investigate the improvements of a recombinant full-length, non-toxic botulinum neurotoxin vaccine compared to a chemically inactivated toxoid vaccine by analyzing protection against botulism and the immune response in two animal models. Understanding of the properties of bacterial toxins allows for production of Next Generation vaccines that are safer, less expensive, easier to produce, and genetically malleable than chemically inactivated toxoids. The studies proposed will direct these advances in toxin vaccinology.

PI_NAMEs: BARBIERI, JOSEPH T (contact);PELLETT, SABINE

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Animal Model;Animals;anti-toxin;Antibodies;Antibody Response;Bacterial Toxins;Biological;Biological Assay;botulinum;botulinum toxin vaccine;Botulinum Toxins;Botulism;Catalysis;Cells;Chemicals;Clostridium botulinum;Collection;cross immunity;Developed Countries;Developing Countries;Development;Disease;Disease Outbreaks;Dose;Engineering;Enzyme-Linked Immunosorbent Assay;exposed human population;Family;first responder;Funding;Future;Genetic;Genetic Engineering;Human;Immune response;Immunize;Immunodominant Epitopes;Immunoglobulin G;Immunoglobulin M;Immunologics;improved;Inactivated Vaccines;Incidence;Informatics;Intoxication;JTB gene;Laboratories;Length;Licensing;Mediating;Memory;Military Personnel;Modeling;Modification;Mus;Mutate;Mutation;nano;neutralizing antibody;next generation;novel vaccines;Oryctolagus cuniculus;Pentas;Population;Populations at Risk;potency testing;prevent;Production;Property;prophylactic;Proteins;receptor binding;Recombinants;Research Personnel;Residual state;response;Risk;Serotyping;Structure;Structure-Activity Relationship;Terrorism;Testing;Toxic effect;Toxin;Toxoids;Translating;Vaccinated;Vaccination;vaccine strategy;Vaccines;vaccinology;Variant;Zinc

PROJECT_TITLE: Vaccines Against Botulism

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairments and cognitive deterioration. Aging is the major risk factor for AD. Furthermore, increasing evidence indicates that astrocytes and microglia are implicated in the pathogenesis of AD. Genome-wide association studies (GWAS) have identified polymorphisms in genes enriched in microglia (e.g. ABCA7 and TREM2) and astrocytes (e.g. APOE and ABCA7) that increase the risk of developing AD. Cellular and animal models to study genotype-phenotype relationship of AD genetic variants enriched in astrocytes and microglia are missing. We have developed a novel bioengineered model of iPSC-derived neural tissue. Our silk-collagen protein-based ‘donut’ scaffolds can support compartmentalized, 3D brain-like tissues over a year, without necrosis. Thus we propose to use our model to study the extent to which AD-linked variants in genes enriched in glial cells produce AD cellular and molecular phenotypes.

PI_NAMEs: HAYDON, PHILIP G;KAPLAN, DAVID L.;TESCO, GIUSEPPINA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Abeta clearance;abeta deposition;Action Potentials;Affect;Aging;aging related;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Animal Disease Models;Animal Model;Apolipoprotein E;apolipoprotein E-4;Apolipoproteins;Architecture;Astrocytes;Axon;Behavior;beta secretase;Binding;Biomedical Engineering;Brain;Cell Culture Techniques;Cell Density;Cell Line;Cell model;Cell Surface Proteins;Cell Transplantation;cell type;Cells;Cholesterol Homeostasis;Code;Cognitive;Collagen;comparison control;Complement;Complex;Data;Deterioration;Diffusion;early onset;Electrophysiology (science);exome;extracellular;familial Alzheimer disease;Functional disorder;Gene Expression;Genes;Genetic Polymorphism;genetic variant;genome editing;genome sequencing;genome wide association study;Genotype;Homeostasis;Human;human subject;immunodeficiency;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Late Onset Alzheimer Disease;Learning;Link;lipid metabolism;Mammals;member;Memory;Memory impairment;Metabolic;Microglia;Modeling;molecular phenotype;Mus;mutant;Mutation;Necrosis;neonatal mice;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuroglia;Neuronal Differentiation;neuronal excitability;neuronal growth;Neurons;novel;Nutrient;Optics;Oxygen;Pathogenesis;Pathologic;Patients;Phagocytosis;Phenotype;Physiological;Population;Porifera;Porosity;precursor cell;Proteins;Risk;Risk Factors;risk variant;Rodent;scaffold;Senile Plaques;Shapes;Silk;Sleep;stem cell technology;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;Technology;three dimensional cell culture;Time;Tissue Model;Tissues;trafficking;Transplant Recipients;Transplantation;TREM2 gene;Variant;whole genome

PROJECT_TITLE: Study of cell-type specific Alzheimer's disease genetic variants using a novel bioengineered model of iPSC-derived neural tissue


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Aggressive community policing, school discipline, and the school-to-prison pipeline criminalize adolescents and ensnare them in the legal system rather than provide support for underlying educational and developmental needs; these phenomena are a hypothesized population driver of adolescent substance use and mental illness, and racialized disparities therein. We will collaborate with the New York City Office of School Health to create unprecedented, geocoded, longitudinal data linkages between police stops/arrests; school- and student-level exclusionary discipline records; and restricted school- and student-level substance use/mental health records. We will estimate direct and mediated relationships between community policing and school discipline on school- and student-level substance use and mental health outcomes; and test whether the spatial concentration of policing around schools, as well as structural and institutional racism, modify these relationships.

PI_NAMEs: PRINS, SETH JACOB (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Adolescence;Adolescent;adolescent health;Adolescent Risk Behavior;adolescent substance use;Adult;African American student;alcohol tobacco and other drug use;Alcohols;Area;Black race;Cannabis;Cities;Collaborations;Color;Communities;critical developmental period;Data;Data Linkages;Data Science;Data Set;Databases;Development;Discipline;disorder prevention;Disparity;Drug usage;Education;Epidemiologic Methods;Epidemiology;experience;federal policy;Geography;Health;health disparity;health equity;health record;High Prevalence;high school;improved;Incidence;Individual;Inpatients;Institutional Racism;interest;juvenile justice system;Knowledge;Legal system;Link;Low income;Mediating;Mental disorders;Mental Health;Methodology;Methods;National Institute of Drug Abuse;Neighborhoods;New York City;Nurses;Outcome;Outpatients;Pathway interactions;people of color;Police;Police Forces;Policies;Policy Maker;Population;population health;Prevalence;prevent;Prevention;Prisons;Professional counselor;Psychiatric epidemiology;Psychiatric Hospitals;psychiatric symptom;Psychologist;Psychopathology;Public Health;public health intervention;Punishment;Race;racial disparity;racism;Records;Research;Research Personnel;response;school health;Schools;Security;simulation;social;social epidemiology;Social Workers;Sociology;spatial epidemiology;Structural Racism;Student Health Services;Students;substance use;Substance Use Disorder;substance use treatment;Surveys;Suspensions;System;Techniques;Testing;theories;Tobacco;trend;twelfth grade;Visit;Vulnerable Populations

PROJECT_TITLE: Estimating the impact of the school-to-prison pipeline on adolescent health: racialized,spatial disparities in policing, school discipline, substance use, and mental illness

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: This project is relevant to human health through its focus on bacterial interspecies interactions, which are fundamental to the formation and function of dynamic communities such as the human microbiome. The mechanisms evolved by bacteria to sense and respond to different species of bacteria are poorly understood. The project is relevant to the mission of NIH for the fundamental discoveries of bacterial adaptive physiological responses to competitor species and to the discovery of specialized metabolites that induce these responses.

PI_NAMEs: STRAIGHT, PAUL D. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Agar;Antibiotics;Area;arm;Attention;Bacillus subtilis;Bacteria;bacterial community;Bacterial Genome;Biological Assay;Biological Models;Biomedical Research;candidate identification;Cells;Chemicals;Chloramphenicol;Chromatography;commensal microbes;Communication;Communities;Complex;CRISPR interference;Cues;Data;Detection;Early Diagnosis;Exposure to;fitness;Foundations;Gene Cluster;Gene Expression;Genes;Genetic;Genetic Transcription;genome analysis;Growth;Health;Human;Human Microbiome;improved;interest;Knowledge;liquid chromatography mass spectrometry;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Microbial Biofilms;microbial community;Mission;Monitor;Motility;Natural Products;nitrogen metabolism;Nuclear Magnetic Resonance;pathogen;Pathway interactions;Phase;Physiological;Population;Population Heterogeneity;Protein Biosynthesis;Protein Synthesis Inhibitors;purine metabolism;Reporter;Resistance;response;ribosome profiling;Scanning;Signal Transduction;Signaling Molecule;Slide;small molecule;Streptomyces;Structure;Surface;System;Testing;transcriptome sequencing;United States National Institutes of Health;Work

PROJECT_TITLE: Genetic and Metabolic Determinants of Bacterial Interspecies Interactions

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_NAME: WISTAR INSTITUTE

PHR: OVERALL - PROJECT NARRATIVE This is a new program project that brings together experts in Epstein-Barr Virus latency, epigenetics, metabolism, and carcinogenesis with core expertise in medicinal chemistry, drug discovery, bioinformatics, and animal models of EBV cancer. The overall goal is to address the unmet medical need associated with EBV epithelial cancers that exceed 180,000 new cancer cases per year and receive generic, non-viral cancer treatments and have high rates of failure, relapse and resistance. The Program brings together multiple institutions and collaborators to elucidate the basic mechanisms of viral latency and oncogenesis in EBV epithelial cancers, and to identify vulnerabilities and strategies for development of new viral-specific therapies to treat EBV epithelial cancers.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Aberrant DNA Methylation;Address;Animal Model;Area;ARID1A gene;Basic Science;Bioinformatics;Biometry;Cancer Biology;cancer cell;Cancer Etiology;cancer therapy;carcinogenesis;Carcinoma;Cessation of life;Chemicals;Collaborations;Combined Modality Therapy;Complex;computerized data processing;CpG Island Methylator Phenotype;CRISPR/Cas technology;Death Rate;Dependence;Development;Diagnosis;DNA Damage;DNA Methylation;drug discovery;Drug Modelings;Enhancers;Epigenetic Process;epigenome;Episome;Epithelial Cells;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Failure;FDA approved;gastric organoids;Genomics;Goals;high throughput screening;Human Herpesvirus 4;Immunotherapy;improved;in vitro testing;in vivo Model;Individual;Infection;inhibitor;innovation;insight;Institution;Integration Host Factors;interdisciplinary approach;interest;latent infection;Latent virus infection phase;Link;Maintenance;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Medical;Metabolic;Metabolic Control;Metabolism;Methionine Metabolism Pathway;Methodology;Modeling;molecular subtypes;mutant;Nasopharyngeal Undifferentiated Carcinoma;Nasopharynx Carcinoma;novel strategies;novel therapeutic intervention;Oncogenic;Oncology;Organoids;Pathway interactions;Patient Care;patient derived xenograft model;Pharmaceutical Chemistry;PIK3CA gene;precision medicine;Precision therapeutics;Process;programs;Refractory;Relapse;Research;Research Personnel;Resistance;response;skills;Somatic Mutation;Stomach Carcinoma;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tool;transcriptome;Translational Research;Treatment Failure;tumor;tumor metabolism;tumorigenesis;Viral;virology;virus genetics;Virus Latency;Xenograft procedure

PROJECT_TITLE: Targeting the Epigenetic and Metabolic Control of EBV-Epithelial Cancers


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases

PHR: PROJECT 1 – PROJECT NARRATIVE EBV epithelial cancers are an unmet medical need accounting for over 170,000 new cancer cases per year. To date, there are no EBV-specific therapies to treat these viral-driven cancers. In this proposal, we investigate how the epigenetic state of the virus and host are deregulated in EBV-associated nasopharyngeal carcinoma (NPC) and gastric carcinomas (EBVaGC). This information will provide fundamental insights into how EBV epigenome is deregulated in EBV-epithelial cancers and provide new strategies to treat EBV cancers.

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;3-Dimensional;Accounting;Affect;ARID1A gene;Automobile Driving;carcinogenesis;Carcinoma;Chromosomes;Collaborations;CpG Islands;DNA Binding;DNA Crosslinking;DNA Damage;DNA Methylation;Epigenetic Process;epigenome;epigenomics;Episome;Epithelial Cells;Epithelium;Epstein-Barr Virus latency;Genes;Genetic Transcription;Genome;Goals;Human Herpesvirus 4;inhibitor;insight;Investigation;latent infection;LMP1;Lytic;Maintenance;Malignant Neoplasms;Medical;Metabolic;Metabolic Control;Methylation;methylation pattern;Molecular Conformation;mouse model;Mutation;Nasopharynx Carcinoma;novel therapeutic intervention;Oncogenic;Pathway interactions;Phenotype;PIK3CA gene;PIK3CG gene;Proteins;Regulatory Element;replication stress;Repression;response;Role;Site;small molecule inhibitor;Stomach Carcinoma;Stress;Testing;therapeutic evaluation;therapeutic target;Transcriptional Regulation;Transcriptional Silencer Elements;Viral;Viral Genome;Viral Oncogene;Virus;Virus Latency;Work

PROJECT_TITLE: Epigenomic Drivers of EBV Epithelial Cancers


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Errors in DNA replication can affect tissue development and cause human diseases, including deficiencies of the immune system and cancer. We propose to study the mechanisms underlying these pathologies to help devise novel diagnostics and therapies.

PI_NAMEs: BIELINSKY, ANJA-KATRIN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Animal Model;Cardiomyopathies;Cell Cycle;Cell Line;Cell model;cell type;Cells;cellular development;Chromosomes;Coupled;Defect;Development;Disease;disease-causing mutation;DNA;DNA biosynthesis;DNA replication fork;Double Strand Break Repair;Family;Genetic;Genome;genome editing;Genome engineering;genome integrity;Genome Stability;Growth;helicase;Heterozygote;Homeostasis;Human;human disease;Immune system;immunodeficiency;In Vitro;induced pluripotent stem cell;insight;interest;Laboratories;Length;Lesion;Link;Maintenance;Malignant Neoplasms;Mitotic;Modeling;Molecular;Mutation;Network-based;Neurodevelopmental Disorder;novel diagnostics;novel therapeutics;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phase;Premature aging syndrome;programs;Proteins;Rare Diseases;repaired;replication stress;Ring Finger Domain;Role;Somatic Cell;Sumoylation Pathway;Telomerase;telomere;Telomere Maintenance;Tissues;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Ubiquitination;whole genome;Work

PROJECT_TITLE: Mechanistic insight into genome stability pathways


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Palliative Care;Patient Safety;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death). We propose to evaluate, in a randomized clinical trial, a strategy of expanded advance care planning (ACP) to support older adults in value-aligned re- assessment of T2D treatment regimens with their primary care team. If the aims of this project are achieved and incidence of clinically-significant hypoglycemia is reduced, this expanded ACP care strategy could be scaled and applied in a wide variety of healthcare settings and chronic conditions in which evolving risks, benefits, and consequences of treatment require re-assessment with age.

PI_NAMEs: GRANT, RICHARD W (contact);SUDORE, REBECCA L

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adult;Advance Care Planning;advanced directive;Adverse event;adverse outcome;Age;age related changes;Age Years;aged;American;California;Cardiovascular system;Caring;Cessation of life;Chronic;Clinical;clinical effect;Clinical Trials;clinically significant;Communication;comorbidity;Complex;Complication;contextual factors;cost;Decision Making;diabetes distress;diabetes management;Diabetes Mellitus;Documentation;efficacy evaluation;end of life;Epidemic;Event;evidence base;Evidence based treatment;experience;falls;Fracture;Future;Glucose;Glycosylated hemoglobin A;Goals;Grant;Health;health care settings;health literacy;Heterogeneity;high risk;Hospitalization;human old age (65+);Hypoglycemia;Impaired cognition;improved;Incidence;Individual;innovation;Insulin;Intervention;Kidney Failure;Life;Managed Care Programs;Medical;Medical center;Medicine;Methods;middle age;mortality;Non-Insulin-Dependent Diabetes Mellitus;older adult;older patient;Older Population;Outcome;Patient Outcomes Assessments;Patient Participation;Patient Preferences;Patient Self-Report;Patients;Patterns of Care;Persons;Pharmaceutical Preparations;Physiology;Population;pragmatic trial;preference;Preparation;Primary Care;primary care provider;primary care setting;primary care team;Provider;Quality of life;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Regimen;response;Risk;Safety;Self Efficacy;skills;Specific qualifier value;success;Sulfonylurea Compounds;support tools;Testing;Time;tool;treatment as usual;treatment effect;Treatment Efficacy;treatment guidelines;Treatment Protocols;treatment risk;usability;Visit;Voice

PROJECT_TITLE: Clinical Trial of Expanded Advance Care Planning to Address Regimen Intensity in Older Patients at High Risk for Treatment-Induced Hypoglycemia

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


PHR: Narrative The American Society for Virology (ASV) fosters the training of junior virologists and teachers of undergraduate virology by encouraging their participation at its annual general meetings. ASV’s annual meeting is the only large general virology meeting in North America. The breadth of virology covered enhances collaborations and opportunities for cross-fertilization of ideas and technologies across the whole of the virus world. This contributes to meeting the health promotion and disease prevention objectives of the NIH mission. There remain major threats to domestic and international health from new and emerging virus diseases, such as the SARS-CoV-2 pandemic of 2020, in addition to more familiar viral diseases that are not yet controllable. This makes the continued training of junior investigators and undergraduate teachers in virology highly relevant. .

PI_NAMEs: SPINDLER, KATHERINE R. (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Academia;Address;American;Animals;Award;Canada;career;Caring;Child Care;Clinical Virology;Collaborations;combat;Communication;Contracts;cost;Country;COVID-19 pandemic;Dedications;Development;disorder control;disorder prevention;doctoral student;Ecology;Education;Educational process of instructing;Educational workshop;emerging virus;essays;Evaluation;Evolution;experience;Fees;Fertilization;Fostering;Foundations;Funding;Future;Goals;Government;Grant;Health;Health Promotion;Housing;Human;Industry;Institution;International;Invertebrates;Knowledge;Leadership;meetings;member;Mentors;Mexico;Microbiology;Mission;Modeling;new technology;next generation;North America;Oral;Participant;Pathogenesis;Plants;Positioning Attribute;Postdoctoral Fellow;posters;pre-doctoral;programs;Prokaryotic Cells;Public Health;Publishing;Quebec;Research;Research Personnel;Research Support;Research Training;Scientist;Senior Scientist;Societies;Structure;Students;symposium;teacher;Technology;Training;Travel;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;virology;Virus;Virus Diseases;virus genetics;virus host interaction;Wisconsin;Woman;Work

PROJECT_TITLE: American Society for Virology Meeting- Jr Investigator Support


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Hematology;Kidney Disease;Nutrition;Urologic Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: NIH/NIDDK Project Narrative The purpose of this training grant to provide intensive short-term training in research areas of interest to NIDDK for 30 selected pre-doctoral medical students in the most outstanding laboratories and training sites in the Yale University School of Medicine. The specific research experiences will range from fundamental molecular biology, cellular and organ physiology to applied clinical research. The program is designed to attract the most highly qualified Yale medical students into careers as physician-scientists in the biomedical sciences in areas of interest to NIDDK.

PI_NAMEs: ARONSON, PETER S.;CHAUDHRY, SARWAT I;HERZOG, ERICA L (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Appointment;Area;Biomedical Engineering;Cardiovascular Diseases;career;design;Diabetes Mellitus;Digestive System Disorders;Educational Curriculum;Endocrinology;Environment;Faculty;follow-up;Genetic;Geriatrics;Health Professional;Hematological Disease;Hematology;Immunobiology;interest;Internal Medicine;Kidney Diseases;Laboratories;Liver diseases;medical schools;Medical Students;Medicine;Mentors;Metabolic Diseases;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Neurosciences;nutrition;Obesity;Operative Surgical Procedures;Pathology;Pediatrics;Pharmacology;Physicians;Physiology;pre-doctoral;Productivity;programs;Psychiatry;Qualifying;Research;Research Project Grants;Research Training;Rheumatology;Schools;Science;Scientist;Site;Students;Training;Training Support;United States National Institutes of Health;Universities;Urologic Diseases;Writing

PROJECT_TITLE: Short Term Research Training: Students in Health Professional Schools

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Stomach Cancer

PHR: PROJECT 2 – PROJECT NARRATIVE EBV infection usually has a benign outcome, yet 1.5% of all cancers worldwide are associated with EBV infection, including 10% of all gastric carcinomas and nearly 100% of nasopharyngeal carcinomas. This proposal will reveal new epigenetic and metabolic vulnerabilities that can be leveraged to treat EBV+ epithelial malignancies specifically.

PI_NAMEs: TEMPERA, ITALO  (contact)

PROJECT_TERMS: 3-Dimensional;base;Benign;cancer cell;Carcinoma;Cells;Cessation of life;Chromatin;Chromatin Loop;Chromatin Structure;Chromosomes;Collaborations;Complex;CpG Island Methylator Phenotype;cytotoxicity;Data;Dependence;Development;DNA;DNA Damage;DNA Methylation;DNA Repair;Drug Targeting;enzyme activity;Enzymes;Epigenetic Process;epigenome;Episome;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;gastric cancer cell;Gene Expression;Gene Expression Regulation;Genes;Genome;genome integrity;Goals;Human Herpesvirus 4;In Vitro;in vivo;inhibitor;latent gene expression;Link;Location;Maintenance;Malignant Neoplasms;malignant phenotype;malignant stomach neoplasm;Mediating;MEKs;Metabolic;Metabolic Control;Metabolism;methylation pattern;Molecular Conformation;Mus;Mutation;NADH;Nasopharynx Carcinoma;novel;Oncogenic;Organoids;Outcome;Pathway interactions;Pharmaceutical Preparations;PIK3CG gene;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Pre-Clinical Model;Production;programs;Proteins;Reader;Recycling;Regulation;response;Role;Signal Transduction;Site;small molecule;Stomach Carcinoma;synergism;Testing;therapeutically effective;three dimensional structure;tumor;tumorigenesis;Viral;Virus Diseases;Virus Latency

PROJECT_TITLE: PARP1-Chromatin and NAD-Metabolism in EBV Epithelial Cancers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Alzheimer’s disease is the most common cause of dementia in the United States, but recent drug trials have failed to show an improvement in cognitive outcomes. Cortical excitability (measured using noninvasive brain stimulation) has the potential to serve as a novel prognostic marker or treatment target, and is relevant to public health due to its potential future applications in Alzheimer’s disease clinical trials. This is directly relevant to the NIH’s mission of advancing the diagnosis, prevention, and cure of human diseases.

PI_NAMEs: BUSS, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Accounting;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Area;Atrophic;Biological Markers;Biometry;Brain;Brain region;career;career development;Clinical;clinical predictors;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Data;Dementia;demographics;design;Development Plans;Diagnosis;Disease Progression;Electroencephalography;experience;Failure;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Future;Goals;human disease;Image;improved;Inferior;innovation;instructor;Israel;Link;Magnetic Resonance Imaging;Measurement;Measures;medial temporal lobe;Medical center;medical schools;Memory;Mentorship;Mission;Modeling;Motor;Motor Cortex;Nerve Degeneration;neuroimaging;Neurologist;Neurology;Neuronal Dysfunction;Neurons;neurophysiology;noninvasive brain stimulation;novel;novel marker;Outcome;Parietal;Parietal Lobe;Participant;Pathogenesis;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;practical application;Prevention;prodromal Alzheimer's disease;Prognosis;prognostic;Prognostic Marker;prognostic value;Public Health;Research Personnel;Research Project Grants;Resolution;response;Rest;restoration;Sampling;Scientist;Site;skills;Stimulus;structural imaging;synaptic function;Techniques;Testing;Therapeutic;therapeutic target;Thick;tool;Training;Transcranial magnetic stimulation;United States;United States National Institutes of Health

PROJECT_TITLE: Understanding the structural, functional, and prognostic implications of cortical excitability in Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Infectious Diseases;Patient Safety;Precision Medicine

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: Project Narrative The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients) for Abdominal and Skin and Soft Tissue Infections  The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients) for Abdominal and Skin and Soft Tissue Infections is a randomized trial of 60 hospitals and nearly 100,000 infected patients to improve physicians’ choice of antibiotics for hospitalized patients by reducing the unnecessary use of broad-spectrum antibiotics. This trial provides prescribers in half the hospitals with prescribing advice based on the probability that a patient is infected with antibiotic resistant bacteria. Unnecessary broad-spectrum antibiotics carry risks, and the goal of this trial is to limit their use to situations in which the patient is likely to require them, while maintaining excellent patient outcomes.

PI_NAMEs: HUANG, SUSAN S.;PLATT, RICHARD  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abdomen;Abdominal Infection;Algorithms;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacterial Antibiotic Resistance;Characteristics;Clinical;Cluster randomized trial;Community Hospitals;computerized;Data;Disease;drug resistant pathogen;Electronic Health Record;Epidemiology;Feedback;Goals;Hospitalization;Hospitals;improved;Infection;Infectious Skin Diseases;Intensive Care Units;Intervention;Intra-abdominal;Knowledge;Length of Stay;Measures;Methods;Organism;Outcome;pathogen;Patient Admission;Patient Selection;Patient-Focused Outcomes;Patients;Physicians;precision medicine;prediction algorithm;Prevalence;Probability;programs;Provider;Randomized;randomized trial;Resistance;Risk;Risk Estimate;routine care;Skin Tissue;soft tissue;Soft Tissue Infections;System;Time;trial comparing

PROJECT_TITLE: INSPIRE (INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients): The INSPIRE-ASP Trial for Intra-Abdominal and Skin and Soft Tissue Infections


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Nanoparticles have emerged as highly specialized multifunctional probes for disease targeting and delivery of small molecule drugs to treat cancerous lesions. Non-toxic ultrasmall fluorescent core-shell silica nanoparticles that induce a potent form of cell death in cancer cells has emerged as an alternative anti-cancer strategy offering wide-ranging potential that harnesses the unique intrinsic therapeutic potential of these particles to combat disease without the need for a cytotoxic agent, in addition to activating immune cells within the tumor microenvironment. The proposed studies will identify particle structural and chemical features that can maximize these intrinsic therapeutic responses in melanoma models, in addition to elucidating their underlying molecular mechanisms and relative contributions to anti-cancer therapies – solutions that may better inform our in vivo study designs and offer a more effective path for product translation.

PI_NAMEs: BRADBURY, MICHELLE S (contact);OVERHOLTZER, MICHAEL H.;WIESNER, ULRICH

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Affinity;anti-cancer;anti-cancer therapeutic;anti-CTLA4;anti-PD-1;anti-tumor immune response;anticancer activity;antitumor effect;Antitumor Response;aqueous;Automobile Driving;Binding;Biology;cancer cell;cancer immunotherapy;cancer regression;cancer therapy;Cancerous;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;Cells;Characteristics;Chemicals;combat;cytokine;Cytotoxic agent;Data;design;Dimensions;Disease;Dose;Encapsulated;Exhibits;experimental study;Fluorescent Dyes;Gel Chromatography;Genetic Engineering;Goals;High Pressure Liquid Chromatography;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;immune-related adverse events;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;inhibitor;insight;Intravenous;intravenous administration;Invaded;Iron;Lead;Lesion;Link;Lipid Peroxides;Macrophage;Malignant Neoplasms;Melanocortin 1 Receptor;Melanoma;Melanoma Cell;Modeling;Molecular;mouse model;Mus;Mutation;nanomaterials;nanoparticle;nanotherapeutic;Necrosis;novel;Outcome;overexpression;particle;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Process;programs;Property;recruit;Research;Research Design;response;Series;Signal Transduction Pathway;Silicon Dioxide;small molecule;synergism;T-Lymphocyte;Therapeutic;Therapeutic Effect;Time;Toxic effect;Translations;Transplantation;Treatment Efficacy;treatment response;tumor;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Ultrasmall particle-based solutions for inducing ferroptosis and improving anti-tumor immune responses in cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Nanotechnology;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: NARRATIVE  This proposal develops a novel delivery platform for the direct delivery of miRNA and siRNA therapeutics to Triple Negative Breast Cancer. RNA nanotechnology’s cancer targeting ability will be applied to exosomes for high payload delivery directly to the cytosol through the control of the orientation of asymmetric nanoparticles for selective surface decoration or exosome loading. Delivery of tumor-suppressing miRNA and siRNA in addition to anti-oncogenic miRNA therapeutics will be tested on patient derived xenograft murine models for tumor treatment and safety profiles.

PI_NAMEs: BINZEL, DANIEL W;SHU, DAN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: aggressive breast cancer;Antibodies;Apoptosis;aptamer;Biodistribution;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;cancer cell;cancer subtypes;cancer therapy;Caveolae;Cell Proliferation;Cells;Chemicals;chemotherapy;Clathrin;Clinic;clinical translation;Clinical Treatment;Clinical Trials;Complex;Cytosol;Data;Death Rate;Drug Delivery Systems;Drug resistance;Dyes;Endocytosis;Endosomes;ERBB2 gene;Estrogen Receptors;Evaluation;exosome;Gene Silencing;Genes;Goals;Growth;Homing;hormone therapy;Hydrophobicity;Image;imaging agent;immunogenicity;In Vitro;in vitro Model;in vivo;Inhibition of Cancer Cell Growth;inhibitor;Investigation;Investigational New Drug Application;KB Cells;knock-down;Label;Lead;lead candidate;Ligand Binding;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Membrane;Membrane Fusion;Methods;Methotrexate;microRNA delivery;MicroRNAs;mouse model;nano;nanocarrier;nanoparticle;Nanotechnology;novel;Oncogenic;Organ;Organelles;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Phagocytosis;pharmacokinetics and pharmacodynamics;pre-clinical;preclinical study;Progesterone Receptors;Prognosis;Proteins;Receptor Cell;Recurrence;Reporting;RNA;RNA Interference;RNA Interference Therapy;Safety;side effect;siRNA delivery;Site;Small Interfering RNA;Surface;survivin;System;targeted delivery;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic miRNA;therapeutic RNA;therapeutic siRNA;Toxic effect;trafficking;Translations;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;Untranslated RNA;uptake;Yin

PROJECT_TITLE: TNBC Ligand-displaying Exosomes Using RNA Nanotechnology for Targeted Cytosol Delivery of RNAi without Endosome Entrapment


PHR: PROJECT NARRATIVE Current sepsis guidelines and national quality measures strongly encourage clinicians to administer immediate broad-spectrum antibiotics and bundled care to all patients with suspected sepsis even though more than a third turn out to have non-infectious diagnoses. A major obstacle for clinicians, hospitals, and policy makers is a limited understanding of which clinical presentations truly require immediate antibiotics and which processes of care are most important to optimizing patients' outcomes. In this project, we will leverage detailed electronic health record data from millions of encounters from two large healthcare networks to 1) develop evidence- based, objective, and electronically computable definitions of sepsis “time zero” that can be used to identify which patients with possible infection require immediate antibiotics, while also facilitating efficient monitoring of sepsis care, 2) systematically evaluate the associations between each sepsis bundle component and mortality and compare the full bundle to simpler, streamlined versions, and 3) assess whether and how optimal treatment strategies differ for commonly encountered and easily recognizable sepsis phenotypes. 1

PI_NAMEs: KLOMPAS, MICHAEL ;RHEE, CHANU  (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Developing Evidence-Based Sepsis Time Zero Criteria and Quality Metrics Using Electronic Health Record Data

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Investigating the neural circuits underlying sensory perception provides a critical window into understanding how the brain functions normally and in disease. Using the sophisticated genetic tools and advanced imaging approaches, this proposal will dissect the mouse brain circuits that impart behavioral valence on odor stimuli. Our work seeks to elucidate fundamental principles in sensory neurobiology that are generally applicable to neuronal processing, with the long-term hope that these principles will provide insight into neurological disorders of sensory systems. !

PI_NAMEs: ROOT, CORY MATTHEW (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Amygdaloid structure;anatomical tracing;Anatomy;Animals;Anterior;Appetitive Behavior;approach behavior;Automobile Driving;avoidance behavior;Behavior;Behavioral;Biological;Brain;Brain region;Calcium;Code;Data;Desire for food;Disease;Emotional;Endoscopy;Esthesia;Exhibits;experimental study;gain of function;Genetic;Goals;Higher Order Chromatin Structure;imaging approach;insight;Instinct;Knowledge;Label;Lateral;loss of function;Measures;Medial;Mediating;microendoscopy;Modeling;Motor output;Mus;Nervous System Disorder;neural circuit;Neurobiology;Neurons;Neurosciences;Nose;Nucleus Accumbens;Odors;olfactory bulb;Olfactory Pathways;Optics;optogenetics;organizational structure;Output;Pathway interactions;Perception;piriform cortex;Play;Population;Positive Valence;response;Role;Sense Organs;Sensory;sensory system;Series;Signal Transduction;Smell Perception;Stereotyping;Stimulus;Structure;System;Testing;tool;Translating;two-photon;Viral;Volatilization;Work

PROJECT_TITLE: Deciphering the neural circuits that mediate innate olfactory behaviors.

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Stomach Cancer

PHR: PROJECT 3 – PROJECT NARRATIVE EBV is a major cause of nasopharyngeal and gastric carcinomas. These studies will increase understanding of how EBV together with specific tumor genetic and epigenetic pathways drive epithelial cancers, which may lead to novel therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROJECT_TERMS: alpelisib;antagonist;Automobile Driving;B-Lymphocytes;Bacterial Artificial Chromosomes;Bioinformatics;Biological Assay;BRCA1 gene;Burkitt Lymphoma;cancer cell;cancer genome;Carbon;Carcinoma;Cell Death;Cells;Characteristics;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;CpG Island Methylator Phenotype;CRISPR screen;Data;Decitabine;dietary;Disease;DNA;DNA Damage;DNA Methylation;DNA Repair;Dose;driver mutation;Enzymes;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;Foundations;G9a histone methyltransferase;gain of function;gastric organoids;Genetic;genome-wide;Genomics;Glutathione Metabolism Pathway;glutathione peroxidase;Growth;histone methylation;homologous recombination;Human;Human Genome;Human Herpesvirus 4;Hyperactivity;Hypermethylation;insight;Integration Host Factors;Isotopes;Knock-out;Knowledge;Latent virus infection phase;Learning;Malignant Epithelial Cell;Malignant Neoplasms;malignant stomach neoplasm;Membrane Proteins;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Methionine;Methionine Metabolism Pathway;Methylation;Modeling;mouse model;Mutagenesis;Mutation;Nasopharynx Carcinoma;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Organoids;Oxidation-Reduction;Oxidative Stress;Pathway interactions;personalized approach;Phosphatidylinositols;Phosphotransferases;Play;programs;Property;Proteins;Proto-Oncogene Proteins c-akt;Reaction;Recombinants;recombinational repair;Regulation;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;Somatic Mutation;Stomach Carcinoma;Testing;The Cancer Genome Atlas;Therapeutic;transcription factor;transcriptome sequencing;Tropism;tumor;tumor metabolism;Tumor Suppressor Proteins;ubiquitin-protein ligase;Viral;Viral Genome;Virus Latency;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Methionine and PI3K Metabolism Drive CIMP in EBV Epithelial Cancers


NIH_SPENDING_CATS: Aging;Bioengineering;Nanotechnology;Wound Healing and Care

ORG_CITY: TAMPA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The public health and economic impact of chronic wound care is staggering, with an estimated annual cost of 28-96 billion dollars. Here, we describe the development of novel therapies for the treatment of chronic wounds.

PI_NAMEs: KORIA, PIYUSH  (contact)

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Affect;aged;American;Amputation;Animal Model;animal old age;Animals;Biodistribution;Biological Products;chronic wound;Clinic;Collection;cost;Data;decubitus ulcer;Development;Diabetic Foot Ulcer;Diabetic mouse;dosage;Drug Kinetics;economic impact;efficacy evaluation;Elderly;Environment;experimental study;Family suidae;Fibroblasts;first-in-human;Growth Factor;Half-Life;healing;Healthcare Systems;Human;improved;ineffective therapies;Inflammation;innovation;Intervention;juvenile animal;Leg Ulcer;Leukocyte Elastase;Liquid substance;loss of function;Matrix Metalloproteinases;Mediating;Morbidity - disease rate;mortality;mouse model;Mus;nanoparticle;novel therapeutics;old mice;older adult;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Phase;Pilot Projects;pre-clinical;preclinical development;Predisposition;Public Health;Quality of life;re-epithelialization;Recombinants;Research Personnel;Resistance;Safety;Side;Site;Technology;Testing;Therapeutic;Translating;Translations;Venous;Work;wound;wound care;wound healing;Wound models

PROJECT_TITLE: Protease Resistant Growth Factor Nanoparticles for Chronic Wound Healing

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Immunotherapy;Infectious Diseases;Patient Safety;Physical Injury - Accidents and Adverse Effects;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells. Here we propose to determine the underlying mechanisms behind the increased expansion of these leukocyte populations and the underlying mechanisms that drive inflammation and immune suppression.

PI_NAMEs: EFRON, PHILIP A (contact);KLADDE, MICHAEL PAUL;MATHEWS, CLAYTON E

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acetylation;Acute;Address;adverse outcome;Aging;Antigen-Presenting Cells;Autoimmune Diseases;Automobile Driving;Basic Science;Blood;Blunt Trauma;Bone Marrow;Cell Respiration;Cells;Cessation of life;checkpoint inhibition;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;clinical infrastructure;Clinical Sciences;Collaborations;comorbidity;conflict resolution;Critical Care;Critical Illness;Development;Discipline;Dysplasia;Emergency Situation;End stage renal failure;Enrollment;Epigenetic Process;Event;Exposure to;Failure;Generations;Genes;Genetic Transcription;Good Clinical Practice;granulocyte;Health;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;high risk;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;Human;Immunity;Immunology;Immunosuppression;improved;improved outcome;Individual;Inflammation;Inflammatory;Injury;Intensive Care Units;Kidney Diseases;Leukocytes;Lymphopoiesis;Malignant Neoplasms;Medical;meetings;Metabolic Pathway;Methylation;Mitochondria;Modernization;Molecular Genetics;monocyte;Myeloid-derived suppressor cells;Myelopoiesis;Nitrogen;novel;novel therapeutic intervention;Nutrient;Operative Surgical Procedures;organizational structure;Outcome;Oxygen;Paracrine Communication;Pathogenesis;patient population;Patients;Pharmaceutical Preparations;Phenotype;Population;Production;progenitor;programs;Quality of life;Research;Research Personnel;Resources;response;Risk;Science;secondary infection;Secondary to;Sepsis;septic patients;Signal Transduction;single-cell RNA sequencing;stem cell function;Stimulus;Surgical Intensive Care;Syndrome;T-Lymphocyte;Testing;Time;Transcription Initiation Site;Trauma;Trauma patient;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology


NIH_SPENDING_CATS: Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: NARRATIVE: Traumatic brain injury is a serious public health concern and the incidence of elderly TBI has doubled in the past twenty years. A further complication in the treatment of TBI occurs due to lack of clear knowledge on sex differences in TBI. This proposal is to understand the influence of age and sex on brain swelling, one of the most devastating symptoms of TBI, and to delineate the underlying mechanisms.

PI_NAMEs: THARAKAN, BINU  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Address;Affect;Age;age difference;age effect;age group;age related;aged;Aging;Area;biological age;biological sex;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Edema;Cellular biology;Cerebral Edema;cerebral microvasculature;Cerebrum;Cessation of life;Clinical;Clinical Trials;Complication;Craniocerebral Trauma;cytokine;Cytoplasmic Granules;Data;Death Rate;Disease;DNA;Economic Burden;effective therapy;Elderly;Electron Microscopy;Endothelium;Enzymes;Estrogens;extracellular;Extravasation;Failure;Female;Fracture;Freeze Fracturing;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;Genetic;Goals;Histones;Impairment;Incidence;Individual;Inflammasome;Inflammatory;inhibitor;insight;Intracranial Pressure;intravital imaging;ischemic injury;Knockout Mice;Knowledge;Liquid substance;male;Mediating;Microcirculation;microscopic imaging;Microtomy;Microvascular Permeability;middle age;Molecular;Molecular Biology;mouse model;mRNA Expression;Mus;neglect;neutrophil;Neutrophil Activation;novel;older patient;Outcome;Pathway interactions;Patients;Peptides;Perfusion;Permeability;Persons;pharmacologic;Population;preclinical study;prevent;Prevention;Protein-arginine deiminase;Proteins;Public Health;Research;response;Severities;sex;Sex Differences;Signal Transduction;Societies;success;Symptoms;TBI Patients;TBI treatment;Testing;therapeutically effective;Tight Junctions;Trauma patient;Traumatic Brain Injury;Vascular Permeabilities;Vasogenic Brain Edema;Vertebral column

PROJECT_TITLE: Influence of Age and Sex on Cerebral Edema Formation Following Traumatic Brain Injury


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Transposable element sequences occupy fifty times more space in our genome than those coding for proteins, yet we know surprisingly little about the significance of these elements in health, disease, and evolution. This project combines genomics and functional assays to test the transformative idea that transposable elements directly impact fundamental developmental processes in vertebrates. We seek to harness these new insights in the promotion of human health.

PI_NAMEs: FESCHOTTE, CEDRIC  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: addiction;Attention;Automobile Driving;Biological;Biological Assay;Biology;Capsid;Cell Physiology;Code;design;Development;Developmental Process;Disease;DNA Transposable Elements;Elements;Embryo;Embryonic Development;Endogenous Retroviruses;Event;Evolution;Funding;Gene Expression;Genes;Genetic;Genetic Variation;Genome;Genomics;Health;Human;human embryonic development;Human Genome;innovation;insight;Invaded;model organism;Modeling;Molecular;Neurodevelopmental Disorder;novel;Outcome;particle;Physiological;Placenta;Pre-Eclampsia;Pregnancy loss;Process;Property;Proteins;Recurrence;Regulatory Element;Research;Retroelements;Shapes;Source;Study models;Testing;Tissues;vertebrate genome;Vertebrates;Viral;Work;Zebrafish

PROJECT_TITLE: Genomic and Physiological Impact of Transposable Elements.

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative The goal of this MARC Program is to provide significant research training to underrepresented students in the sciences to help them successfully enter high-quality PhD or MD/PhD Programs in the biomedical-related sciences. The ultimate goal is to increase the number of underrepresented biomedical and behavioral scientists in leadership career positions that advance the health-related research needs of the nation. Our target outcome is to achieve 80% of our Trainees entering high-caliber PhD or MD/PhD programs within 3 years of graduation.

PI_NAMEs: MARTINEZ, ERNEST  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: base;Behavioral Sciences;Biomedical Research;biomedical scientist;Caliber;California;career;CCL7 gene;community college;Critical Thinking;design;Doctor of Philosophy;Eligibility Determination;Ethics;experimental study;faculty mentor;Fellowship;Generations;Goals;Grant;high school;Institution;interest;Laboratories;Learning;Minority;minority student;Modernization;outreach;Paper;Positioning Attribute;Program Development;programs;Qualifying;Reporting;Research;Research Methodology;role model;Science;student participation;Students;Training;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Writing

PROJECT_TITLE: MARC at University of California Riverside

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

PHR: CORE A – PROJECT NARRATIVE Core A will function as both the Administrative organization unit and Biostatistical support for this Program Project. Core A will provide all Program Members with essential Administrative support for fiscal management and scientific integration, including communication of data, meetings and interactions with advisory committees. Core A will also provide Biostatistics support for all members of the Program. This will include data analysis, statistical design, hypothesis testing, and a centralized environment for data management, quality control, analysis and transfer within the program.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Biological;Biometry;carcinogenesis;Carcinoma;Communication;Communities;complex data;Data;Data Analyses;data communication;data management;Data Set;design;Education and Outreach;Ensure;Environment;Epigenetic Process;Epithelium;Evaluation;Goals;Grant;Guidelines;Human Herpesvirus 4;Human Resources;Leadership;meetings;member;Metabolic Control;Mission;Organization administrative structures;outreach;Pathway Analysis;programs;Protocols documentation;Quality Control;Reagent;Reporting;Reproducibility;Research Personnel;Resource Sharing;Resources;Schedule;Statistical Methods;Structure;Technology;Testing;therapy development

PROJECT_TITLE: Administrative and Biostatistics


NIH_SPENDING_CATS: Aging;Sarcopenia

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE A widely conserved hallmark of aging is the decline in muscle mass and strength, which promotes frailty, loss of independence and disability. Based on new evidence we garnered in aging WT mice and mice with muscle- specific inducible PGC1a ablation, we hypothesize that the bioenergetic stimulation induced by intermittent glucocorticoid dosing rescues aging muscle quality through a coordinated action on mitochondrial dysfunction and sarcopenia. We will use our newly generated inducible transgenic models to establish the previously unrecognized roles of mitochondrial regulators PGC1a and Lipin1 in aging physiology through ablation AFTER natural aging.

PI_NAMEs: QUATTROCELLI, MATTIA  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Ablation;Adult;age related;Aging;aging mechanism;aging related;Alanine;Amino Acids;aminoacid biosynthesis;Anabolism;Animal Model;Bioenergetics;Biogenesis;Carbon;Cell Respiration;Chronic;Citric Acid Cycle;Data;density;disability;Dose;Energy Metabolism;frailty;Genetic;Genetic Diseases;Glucocorticoids;Glucose;Growth;hallmarks of aging;Knock-out;Knockout Mice;Knowledge;Link;Lipids;lipine;mass spectrometric imaging;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Mus;Muscle;muscle aging;muscle form;Muscle function;muscle strength;Muscular Dystrophies;Myopathy;normal aging;old mice;overexpression;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Physiology;Prednisone;programs;Protein Biosynthesis;Pyruvate;Regimen;Rejuvenation;Reporting;Respiration;response;risk/benefit ratio;Role;sarcopenia;Steroids;Testing;Thinness;Transgenic Model;treatment effect;trend;wasting;young adult

PROJECT_TITLE: Coordinated mechanisms to rescue bioenergetics and sarcopenia in aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Stomach Cancer

PHR: CORE B – PROJECT NARRATIVE The Chemical Probes and Drug Discovery (Core B) will support all three Projects and work coordinately with Cores A and C to develop new therapeutic strategies to treat EBV epithelial cancers. Core B will provide synthetic/medicinal chemistry expertise and high-throughput drug combination screening for all the Projects. Core B will develop new chemical probes and small molecule inhibitors of viral and host epigenetic modulators to investigate and develop new therapeutic strategies to treat latent infection of EBV focusing on epithelial cancers.

PI_NAMEs: SALVINO, JOSEPH M (contact)

PROJECT_TERMS: Antineoplastic Agents;assay development;Binding;Biochemical;Biological Assay;Biology;Cancer cell line;Carcinoma;Cell Cycle Progression;Cell model;Cells;chemical synthesis;Chemicals;Clinical;clinically relevant;Combined Modality Therapy;CpG Island Methylator Phenotype;Cytosine;Data;Decitabine;demethylation;design;Development;Diversity Library;DNA;DNA Methylation;Drug Combinations;drug discovery;efficacy study;Enzymes;Epigenetic Process;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;gastric cancer cell;Gene Expression Regulation;high throughput screening;Human Herpesvirus 4;improved;in vivo;inhibitor;inhibitor therapy;innovation;latent infection;Lead;lead optimization;lead series;Libraries;Ligands;Malignant Neoplasms;Mammalian Cell;Measures;Metabolic Control;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Oligonucleotides;Pennsylvania;Pharmaceutical Chemistry;Pharmaceutical Preparations;PHD Finger;Play;Poly(ADP-ribose) Polymerase Inhibitor;protein function;Proteins;prototype;recruit;Ring Finger Domain;scale up;screening;Screening Result;Signal Pathway;small hairpin RNA;small molecule inhibitor;synergism;Synthesis Chemistry;tool;trimethyllysine;tumor growth;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Universities;Virus Inhibitors;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: Chemical Probes and Drug Discovery