NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

PHR: PROJECT NARRATIVE The incidence of adult and congenital syphilis continues to rise in the US and around the world and vaccines will be integral in ending this epidemic. The findings in this study will contribute to the rational design of candidate vaccines to enter clinical trials.

PI_NAMEs: REID, TARA BRINCK (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: acquired immunity;adaptive immune response;Address;Adult;Aftercare;Antibodies;Antibody Response;Antigens;B-cell receptor repertoire sequencing;B-Lymphocytes;Bacteria;biobank;Biological;Biopsy;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell secretion;cell type;Cells;chemokine;Child;Clinical;Clinical Trials;Communities;comparison control;Congenital Syphilis;curative treatments;cytokine;Data;Data Set;Dendritic Cells;Dermal;design;Disease;effective therapy;Elements;Epidemic;Epitopes;Exanthema;extracellular;Gene Expression Profile;Genes;Goals;healing;Hematopoietic;Human;Immune;immune cell infiltrate;Immune response;Immunobiology;Immunoglobulin G;Immunoglobulin-Secreting Cells;Immunohistochemistry;Immunology;improved;In Situ;Incidence;Infection;Infiltration;Inflammatory;Inflammatory Infiltrate;Innate Immune Response;Institutional Review Boards;Interferon Type II;Interferons;Knowledge;Lesion;Leucocytic infiltrate;Leukocytes;Lymphoid Tissue;Macrophage;Macrophage Activation;Measures;Mediating;Membrane Proteins;Memory;men who have sex with men;Mentors;Methods;Modeling;Myeloid Cells;next generation;Oryctolagus cuniculus;pathogen;Pathogenesis;Pathway interactions;Penicillins;Peptides;Performance;Persons;Phagocytosis;Plasma Cells;Population;Prevalence;Prevention;Proteins;Protocols documentation;Public Health;rational design;Reaction;Recombinants;reconstruction;recruit;Reporter;Reporting;Research;response;Scourge;single cell analysis;single-cell RNA sequencing;skills;Skin;skin lesion;Specificity;Syphilis;syphilis vaccine;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technology;Time;Tissues;tool;Training;transmission process;Treponema pallidum;Treponema pallidum subspecies pallidum;Underrepresented Minority;United States National Institutes of Health;Vaccination;vaccine candidate;Vaccine Design;vaccine strategy;Vaccines;Validation;Woman;Work;γδ T cells

PROJECT_TITLE: Local and systemic immune responses during syphilis infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The neuron-glia switch orchestrating sequential production of neurons and glia from distinct neural progenitors is essential for functional nervous system development and successful regeneration after injury. This proposal aims to identify how factors modulate Wnt signaling to regulate the neuron-glia switch and drive gliogenesis in neural progenitor cells during development and following spinal cord injury. The proposed experiments will provide insight into the molecular mediators of neural progenitor specification and emphasize the importance of the neuron-glia switch during development and after injury.

PI_NAMEs: ARENA, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Affect;Axon;Binding;Binding Sites;Cells;Chromatin;CRISPR/Cas technology;Data;Development;Dose;experimental study;Failure;functional restoration;gain of function;Gene Expression;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;glial cell development;Glial Differentiation;gliogenesis;graduate student;Image;imaging modality;Imaging Techniques;Immunohistochemistry;in vivo;Injury;injury recovery;insight;Larva;loss of function;Mammals;Maps;Mediator;Molecular;Motor Neurons;multiple omics;Mutagenesis;myelination;Natural regeneration;nerve stem cell;nervous system development;Nervous System Disorder;neural circuit;neurogenesis;Neuroglia;Neuronal Differentiation;neuronal survival;Neurons;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;pharmacologic;Positioning Attribute;Postdoctoral Fellow;precursor cell;Process;Production;progenitor;regenerative;Regulation;response;Role;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;Spinal Cord;Spinal cord injury;stem cell differentiation;stem cell fate specification;stem cell population;stem cell proliferation;stem cells;Supporting Cell;Techniques;Testing;tool;Training;Transcript;transcription factor;Transgenic Organisms;Vertebrates;Visualization;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Investigating the role of Wnt signaling effectors on the neuron-glia switch and OPC specification during development and after injury.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: A key feature of substance use disorder is pathological behavioral engagement with rewarding stimuli despite negative outcomes, yet the neural mechanisms driving these behaviors remain unresolved. Consumption of many classes of abused drugs is established to induce maladaptive changes in the endocannabinoid signaling system within the Nucleus Accumbens, a key nodal structure in the neurocircuitry of addiction. In this proposal, we will use cutting-edge in vivo genetic and imaging approaches to dissect how endocannabinoids regulate engagement in reward seeking behaviors through a Paraventricular Thalamus-Nucleus Accumbens circuit to deepen our understanding of substance use disorders and the neural mechanisms of cannabis action.

PI_NAMEs: MARCUS, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;addiction;Affect;Algorithms;Amygdaloid structure;Anatomy;Anterior;Area;Behavior;Behavioral;Behavioral Paradigm;Binding;Brain region;Cannabinoids;Cannabis;career;Chronic;CNR1 gene;Computer Analysis;conditioned fear;Consumption;CRISPR/Cas technology;Data;driving behavior;drug of abuse;drug seeking behavior;Drug usage;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;experimental study;Fiber;Functional disorder;Genetic;genetic approach;Genetic Markers;Goals;Grant;hindbrain;Hypothalamic structure;Image;imaging approach;Impairment;in vivo;insight;Knock-out;Label;Laboratory Research;Link;Machine Learning;marijuana use;marijuana use disorder;Measures;Modeling;Molecular;motivated behavior;Motivation;Mus;nerve supply;neural;neural circuit;neural correlate;Neurobiology;neuromechanism;Neurons;Neuropeptides;neuroregulation;Neurosciences;Neurotensin;Nodal;novel;Nucleus Accumbens;optogenetics;Outcome;Output;Pathologic;Pathway interactions;Pattern;Peptides;Phase;Photometry;Photons;Population;Process;Production;Property;Prosencephalon;receptor;receptor expression;Regulation;Research;Research Personnel;Resolution;restoration;Rewards;selective expression;Self Administration;sensor;Series;Signal Transduction;Site;skills;Specificity;Stimulus;Structure;Structure of paraventricular nucleus of thalamus;Structure of terminal stria nuclei of preoptic region;Substance Use Disorder;Synapses;System;Testing;Tetrahydrocannabinol;Thalamic structure;Training;zona incerta

PROJECT_TITLE: Endocannabinoid modulation of behavioral engagement via an aPVT-NAc circuit

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Physical Activity;Prevention;Rehabilitation;Telehealth

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Systolic blood pressure (SBP) above normal, healthy levels (i.e., ≥120 mmHg) is associated with increased risk for cardiovascular diseases. I recently established the clinical efficacy of high-resistance inspiratory muscle strength training (IMST), a novel form of physical training with minimal barriers to adherence, for lowering SBP in a clinical trial with regular clinic-based, researcher-supervised training. This R03 application seeks to leverage the growing field of digital health technologies to pilot test a smartphone app that independently guides users through a high-resistance IMST program, a key step to translate IMST for widespread use and improving public health.

PI_NAMEs: CRAIGHEAD, DANIEL HARRISON (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Adherence;Adopted;Adult;Adverse event;Aerobic Exercise;Age;American Heart Association;Biomedical Research;Blood Pressure;blood pressure control;Blood Pressure Monitors;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cellular Phone;Chronic Disease;Chronic Kidney Failure;Clinic;clinical efficacy;clinical practice;Clinical Research;Clinical Trials;Communities;community setting;comparative efficacy;Consumption;cost;Data;Dementia;design;Devices;digital health;Disease;Dissemination and Implementation;Double-Blind Method;Dropout;Educational Intervention;effective therapy;effectiveness testing;Elements;Endothelium;Environment;exercise program;Feedback;follow-up;Funding;Future;Goals;good diet;handheld equipment;Health;Health Technology;healthy lifestyle;Home;Hypertension;Impaired cognition;improved;Inhalation;innovation;Innovative Therapy;insight;instrument;Intervention;lifestyle intervention;Measures;Mediating;men;mHealth;Minor;modifiable risk;Monitor;muscle strength;National Heart, Lung, and Blood Institute;new epidemic;novel;Participant;Pilot Projects;pilot test;portability;pressure;primary outcome;Public Health;Randomized;Randomized, Controlled Trials;remote monitoring;Research;Research Design;Research Personnel;Research Priority;Resistance;Safety;smartphone application;strength training;Supervision;Time;Training;Training Programs;Translating;Translations;Travel;trial design;United States;uptake;vascular endothelial dysfunction;Vascular Endothelium;Woman

PROJECT_TITLE: Smartphone app-guided inspiratory muscle strength training for lowering systolic blood pressure

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Contraception/Reproduction;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Puberty is a critical period for neuroendocrine development characterized by substantial neuroplasticity and changing sex hormone levels, which are poorly understood in humans. Innovative analytic strategies are needed for integrating data from multiple approaches (i.e., large- and small-scale datasets with sparse and dense longitudinal sampling) to better characterize the contributions of long-term pubertal changes, and more short- term monthly variability in hormones as it pertains to structure and function of the developing brain. The proposed study will apply machine learning to assess hormone-related brain structure and functional connectivity, the roles of sex hormones in microstructure-function coupling across the brain, and the impact of hormone variability and sampling design on identified neuroendocrine phenomena.

PI_NAMEs: BOTTENHORN, KATHERINE LOUISE (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Adolescence;Adolescent;Androgens;Animals;Apoptosis;Architecture;Area;Autopsy;Behavior;Biological Process;biophysical model;Brain;Brain Diseases;BRAIN initiative;cognitive development;Communities;Complement;connectome;Contraceptive Usage;Coupling;critical period;Data;Data Collection;data integration;Data Set;dehydroepiandrosterone;Dendrites;design;Development;Diffusion Magnetic Resonance Imaging;Endocrine;Error Sources;Estradiol;Estrogens;Exhibits;experience;Female Adolescents;Functional Magnetic Resonance Imaging;Funding;girls;Goals;Gonadal Steroid Hormones;Hormone Receptor;Hormones;Human;Image;in vivo;Individual Differences;innovation;innovative technologies;insight;Investigation;Least-Squares Analysis;Link;Literature;Machine Learning;Magnetic Resonance Imaging;Measures;Mediating;Mentors;model generalizability;Modeling;Morphology;neural;Neuroanatomy;neurobiological mechanism;Neurobiology;neurodevelopment;Neuroendocrinology;neuroimaging;neuromechanism;Neuronal Plasticity;Neurosecretory Systems;novel;Participant;Phase;Population;pre-trained model;precision medicine;predictive modeling;Prevalence;Progesterone;Progestins;Psychopathology;Puberty;receptor expression;Research;Research Personnel;Resources;Role;role model;Sampling;sex;Sex Differences;Staging;Structure;Technology;Testing;Testosterone;Thick;Time;tool;Training;white matter;Work;Youth

PROJECT_TITLE: Endocrine-mediated pubertal brain network development: Bridging datasets with machine learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: CENTER NARRATIVE CLiMB’s mission is to preserve, restore, and enhance functional mobility, independence, and participation in Veterans with lower limb loss or other musculoskeletal impairments. To accomplish this mission, CLiMB conducts research to prevent Veterans from developing disabilities from diseases, develops innovative devices to assist Veterans in their mobility, discovers effective treatment and rehabilitation strategies, and creates treatments and clinical tools that allow for an individualized approach to treating Veterans. The Veterans we serve include the hundreds of thousands at risk for limb loss and the tens of thousands who have experienced it, for whom the VA is committed to lifelong clinical management and care. We achieve our mission by conducting rigorous research and development, informing Veteran patients and providers, and translating knowledge and devices to the point of care.

PI_NAMEs: KLUTE, GLENN  (contact);LEDOUX, WILLIAM R.

PROJECT_TERMS: 3D Print;Acceleration;Achievement;active duty;Amputation;Area;Basic Science;Biomechanics;Biometry;Caring;Clinical;clinical care;Clinical Management;Clinical Practice Guideline;Clinical Research;clinical translation;Collaborations;commercialization;comorbidity;Computer Models;Decision Aid;Development;Device or Instrument Development;Devices;disability;Disease;effective therapy;Engineering;engineering design;Ensure;Epidemiologist;Epidemiology;Evidence based treatment;Evolution;experience;functional outcomes;Future;healing;human subject protection;Image;Impairment;Industry;Injury;innovation;International;Intervention;Knowledge;Laboratories;Leadership;limb loss;Lower Extremity;Medical;Mission;mobility aid;Mobility disability;Motion;multidisciplinary;Musculoskeletal;new technology;next generation;novel strategies;Operative Surgical Procedures;Orthopedics;Orthotic Devices;pain reduction;Pathway interactions;Patients;personalized approach;Phase;Physicians;point of care;preservation;prevent;Prevention;Principal Investigator;Prosthesis;prototype;Provider;rehabilitation research;rehabilitation science;rehabilitation strategy;Rehabilitation therapy;Research;research and development;Research Design;Research Personnel;Resources;Risk;Scientist;Services;shared decision making;simulation;Structure;success;support tools;Techniques;tool;Training;Translating;Translations;Trauma;treatment strategy;Underrepresented Minority;United States Department of Veterans Affairs;Veterans;Women's cohort;Work

PROJECT_TITLE: Department of Veterans Affairs Rehabilitation Research & Development Center for Limb Loss and MoBility (CLiMB)

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Genetics;Natural Products;Nutrition

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Natural products – small molecules from plants and microorganisms – have been a primary source of clinically-used antibiotics, antifungals, anticancer agents, immunosuppressants, and other drugs. This proposal describes new approaches to discovering the biosynthetic pathways for natural products from plant genomes. Identifying these pathways will lead to a greater understanding of the chemistries plants use to synthesize biologically active natural products, ensure ready access to molecules that are currently obtained from difficult-to-cultivate plants, and enable the engineered production of plant natural product derivatives with improved biological properties.

PI_NAMEs: SATTELY, ELIZABETH SUSAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Active Sites;Address;Agrobacterium;Alkaloids;Alzheimer's Disease;Amaryllidaceae Alkaloids;Anabolism;analog;analytical tool;anti-fungal agents;Anti-viral Agents;Antibiotics;Antineoplastic Agents;Artemisinins;Biological;Biological Assay;Biological Products;Breeding;Candidate Disease Gene;candidate identification;Cell Culture Techniques;cell type;cephalotaxine;Cephalotaxus;Chemistry;Citrus;Clinical;clinical candidate;Clinical Pathways;Colchicine;combinatorial;comparative;Complex;Cytochrome P450;Data;Dedications;Development;dietary;Digoxin;disorder prevention;Dopamine;Drug usage;Edible Plants;Engineering;Ensure;enzyme pathway;Enzyme Tests;Enzymes;Etoposide;Evaluation;experimental study;Family;Food;food consumption;Fruit;Galantamine;Gene Conversion;Gene Expression Profiling;Generations;Genes;Genetic;Glycoside Hydrolases;Health;homoharringtonine;Human;Hybrids;Immune;Immunosuppressive Agents;improved;in silico;Infiltration;inhibitor;insight;Knowledge;leukemia;Libraries;Ligase;manufacturing facility;Medicine;metabolomics;microorganism;milligram;Morphine;natural product derivative;Natural Products;Nature;Needles;Nervous System Disorder;novel;novel strategies;Nutrient;Outcome;Paclitaxel;Pathway interactions;Pharmaceutical Preparations;Phylogeny;Plant Genome;Plant natural product;Plants;Plum;polyketide synthase;Process;Production;Property;protein degradation;Pyrrolizidine Alkaloids;reconstitution;Role;Route;scaffold;Side;small molecule;Source;success;Taxus;Technology;Tobacco;Tomatoes;tool;transcriptomics;Vinblastine;Work;Yeasts

PROJECT_TITLE: Discovery and Engineering of Plant Natural Product Pathways

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Microbiome;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The microbiome is associated with neurodevelopmental phenotypes in many human diseases, including autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia. Though we know that mode of delivery can determine the initial seeding of the microbiome, we do not know how it may affect neurodevelopment. This work will use a mouse model of Caesarean-section delivery to determine how birth mode changes the pre-weaning microbiome and neurodevelopment in specific brain regions.

PI_NAMEs: LESSING, JEREMY K (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Affect;Anesthesia procedures;Animal Model;Antibiotics;Asthma;Atopobium vaginae;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic behaviour;Bacteria;Bacterial Genes;beta diversity;Biological;Birth;Brain;Brain Hypoxia-Ischemia;Brain region;Cecum;Cells;Cerebellum;Cesarean section;Child;Childhood;Cohort Studies;Communication;Communities;critical period;design;Development;developmental disease;Ecology;Emotional;Epidemiology;Etiology;Exclusion;Exhibits;Experimental Designs;Feces;Food Hypersensitivity;Fostering;fungus;Future;gastrointestinal;Gene Expression;Gene Expression Profile;Genes;Genetic Predisposition to Disease;Goals;gut colonization;gut microbiome;gut microbiota;gut-brain axis;Hippocampus;Histology;Human;human disease;human fetal brain;ileum;Impairment;Infant;Insulin-Dependent Diabetes Mellitus;ischemic injury;Knowledge;Label;Language;Large Intestine;Learning;Learning Disabilities;Life;Mammals;maternal microbiota;Medial;Medical;Memory;Messenger RNA;Methods;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome analysis;microbiome composition;microbiome therapeutics;microbiota;Modeling;Mothers;Motor;mouse model;mRNA Expression;Mus;myelination;neonatal period;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurosciences;Newborn Infant;next generation sequencing;Obesity;offspring;Pathogenesis;Pathway interactions;Pattern;Phenotype;Physicians;Population;postnatal;postnatal development;postnatal period;Prefrontal Cortex;pregnant;Prevalence;Proliferating;Prosencephalon;protein expression;pup;Regulation;Research;Research Personnel;response;restoration;Ribosomal RNA;Risk;Rodent;S phase;Sampling;Schizophrenia;Scientist;Second Pregnancy Trimester;sensory integration;skills;Social Interaction;stressor;Structure;System;Technology;Testing;Tissues;Training;transcriptomics;transmission process;Transplantation;Universities;Vagina;Vaginal delivery procedure;vaginal microbiota;Virus;Weaning;Work;Writing

PROJECT_TITLE: Caesarean Delivery's Effect on the Early Life Microbiome and Neurodevelopment


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Heart Disease;Hematology;Psoriasis

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Psoriasis increases the risk of cardiovascular disease 50% above matched controls. This study will investigate mechanisms in the development of cardiovascular disease by characterizing vascular endothelial disturbances and platelet reactivity in patients with psoriasis. We aim to identify potential therapeutic targets with the eventual goal of developing therapeutic interventions to reduce cardiovascular disease in this at-risk population.

PI_NAMEs: GARSHICK, MICHAEL SETH (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Adhesions;Affect;Age;American;Aorta;Atherosclerosis;Biological;Biology;Blood Platelets;Blood Vessels;brachial artery;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Cell Adhesion;Chronic;chronic inflammatory skin;Clinical;clinical development;clinical translation;collaborative environment;comparison control;Cross-Sectional Studies;cytokine;Data;Dermatology;Development;differential expression;Disease;Effector Cell;Endothelial Cells;Endothelium;Ethnic Origin;Event;Exhibits;Future;Genes;Goals;Harvest;Health;Human;IL17 gene;illness length;immune activation;Immunology;Impairment;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;inflammatory marker;innovation;Intercellular adhesion molecule 1;Interleukin-1 beta;Interleukin-6;Interleukin-8;Investigation;Joints;Laboratories;Measures;Mediating;Methodology;Methods;Modality;mortality;Myocardial Infarction;New York;overexpression;Pathogenesis;Pathway interactions;Patients;Physiologic pulse;Platelet Activation;Platelet aggregation;platelet function;platelet phenotype;Populations at Risk;Production;Proteins;Psoriasis;Publishing;Race;randomized trial;randomized, clinical trials;recruit;Recurrence;Reporting;Research;Research Design;Rheumatology;Risk Reduction;Role;Serum;Severity of illness;sex;Signal Pathway;Signal Transduction;Skin;skin disorder;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;TNF gene;Transcript;transcriptome sequencing;translational scientist;United States National Institutes of Health;Universities;vascular endothelial dysfunction;Vascular Endothelium;Veins;Venous;Whole Blood

PROJECT_TITLE: Endovascular Health and Platelet Activity in Psoriasis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Veterinary students are uniquely qualified in comparative medicine, a training that is a valuable resource in the biomedical sciences and particularly animal models of diseases. This competing renewal proposal will support the continuation of our Summer Veterinary Student Research Program (SVSRP) at the Virginia-Maryland College of Veterinary Medicine (VMCVM) to train veterinary medicine students in acquiring research skills. The SVSRP is designed to increase the appreciation of research by DVM students, incorporate research skills in their future careers, and to consider research-based careers.

PI_NAMEs: AHMED, S ANSAR (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academia;Accreditation;Animal Model;Animal Welfare Act;Area;Belmont Report;Biomedical Research;Biometry;Biotechnology;career;Clinical Research;college;Communicable Diseases;comparative;experience;Experimental Designs;Exposure to;Funding;Government;hands on research;Human Experimentation;Human Subject Research;Immunology;Industry;Inflammation;Institution;interest;Laboratories;Learning;Maryland;medical schools;Medicine;meetings;Mentors;Mississippi;Neurosciences;Oncology;Paper;programs;Public Policy;Qualifying;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Proposals;Resources;responsible research conduct;Role;skills;Students;summer research;Training;Training Programs;Underrepresented Minority;United States Department of Agriculture;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Virginia;Visit;Visual;Washington;Writing

PROJECT_TITLE: Summer Veterinary Student Research (SVSRP)


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE It has been demonstrated that diverse groups lead to increased productivity in the workplace. In STEM fields, this diversity is lacking with limited participation of members from minority groups. The UMB IMSD program will focus on the recruitment, retention, and professional development of students from underrepresented groups to prepare them for careers in biomedical science.

PI_NAMEs: OGLESBY, AMANDA GAIL;STRICKLAND, DUDLEY K.;WEBB, TONYA J.;WILKS, ANGELA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: UMB IMSD

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Rural Health

ORG_CITY: LOUISVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Because of the Kentucky's large economically disadvantaged population and the race and gender gap in academia, it is imperative to provide underrepresented students in Kentucky with the tools they will need to apply and succeed in graduate school. The overall objective of this research education program is to recruit and train the next generation of underrepresented scientists in the STEM fields by developing a unique integrated education program among faculty of the Medical, Dental, Arts and Sciences, and Engineering schools at the University of Louisville. This program will provide students from Kentucky and surrounding area underrepresented in STEM extensive research training in various biomedical disciplines, and development of various skills necessary to become successful scientists and of a strong sense of belonging in science.

PI_NAMEs: ALARD, PASCALE  (contact);BERTOCCI, KAREN L.;CORBITT, CYNTHIA ;URIARTE, SILVIA M

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Achievement;Address;Admission activity;Advisory Committees;African American;Applied Skills;Area;Arts;Biomedical Research;Books;Cardiovascular system;career;career development;cohort;Collaborations;college;Communication;Communities;Critical Thinking;Data;Dental Faculty;Dentistry;design;Development;Development Plans;disadvantaged student;Discipline;economic disparity;Economically Deprived Population;Education;education research;Educational workshop;Engineering;Environmental Health;Ethical Issues;expectation;experience;Face;Faculty;falls;Feedback;Fostering;Future;Gender;Generations;Goals;graduate school;graduate school preparation;Growth;Hispanic;Historically Black Colleges and Universities;improved;Individual;Inequity;Information Literacy;innovation;interest;Journals;Kentucky;Laboratories;Latino;Learning Skill;learning strategy;life-long learning;Medical Faculty;medical schools;Medicine;meetings;Mentors;Methodology;Minority Participation;next generation;oral communication;Outcome;Postbaccalaureate;Principal Investigator;programs;promote resilience;Publishing;Race;recruit;remediation;Reporting;Research;research and development;research facility;Research Project Grants;Research Training;resilience;Rotation;Rural;rural area;Scholars Program;School Dentistry;Schools;Science;Scientist;Series;skill acquisition;skills;social media;Speed;STEM field;Strategic Planning;student mentoring;student participation;Students;success;summer research;Time;tool;Training;training opportunity;translational neuroscience;undergraduate student;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;urban area

PROJECT_TITLE: University of Louisville Biomedical Integrative Opportunity for Mentored Experience Development -PREP (UL-BIOMED-PREP)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Deaths from esophageal adenocarcinoma continue to rise, yet factors driving this trend remain poorly understood. We hope to demonstrate that the inter-relationship between gastro-esophageal reflux bile acid composition, Notch signaling activity, and esophageal bacterial composition is key to driving esophageal neoplasia. This knowledge can in turn be translated to future efforts to modify these factors to prevent esophageal cancer.

PI_NAMEs: ABRAMS, JULIAN  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Acceleration;Acids;Antibiotics;Area;aspirate;Automobile Driving;Bacteria;Barrett Esophagus;Bile Acids;carcinogenesis;carcinogenicity;Case/Control Studies;Cell Differentiation process;Cessation of life;Chronic;Clinical;cohort;Collaborations;Colon;Colon Carcinoma;Data;Deoxycholic Acid;Development;Dysplasia;Enrollment;Enterobacteriaceae;Epithelium;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophageal Tissue;Esophagus;experimental study;Feedback;Future;gastric microbiome;Gastroesophageal reflux disease;gastrointestinal epithelium;Goals;Goblet Cells;gut microbiome;Helicobacter Infections;Helicobacter pylori;High grade dysplasia;high risk;Homeostasis;Incidence;infection rate;Inflammation;Intervention;Intestines;Knowledge;Lesion;Logistic Regressions;Malignant neoplasm of esophagus;Malignant Neoplasms;Microbial Biofilms;microbiome;microbiome alteration;microbiome composition;Minority;Modeling;modifiable risk;mouse model;Mucins;Mucous body substance;Mutagens;Neoplasms;NF-kappa B;notch protein;novel;Obesity;Organoids;Pathway interactions;Patients;Population;Prevalence;prevent;Probiotics;Production;Prognosis;prospective;Prospective cohort;Public Health;Research;Risk;Risk Factors;Role;Sampling;Series;Signal Transduction;Stomach;Study models;Testing;Thinness;Time;Tissue Sample;Translating;trend;Upper digestive tract structure;Work

PROJECT_TITLE: The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: SHEPHERD CENTER

ORG_STATE: GA

PHR: .PROJECT NARRATIVE. With aging of our population and growing numbers of persons with disability, rehabilitation research is increasingly essential. However, rehabilitation researcher lags other areas of biomedical research. We propose a vibrant and intensive year-long program to strengthen the rehabilitation research workforce.

PI_NAMEs: FIELD-FOTE, EDELLE C. (contact);STEVENS-LAPSLEY, JENNIFER E.

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Accidents;Address;Affect;Age;Aging;Applications Grants;Area;Award;baby boomer;Biomedical Research;Biometry;Budgets;career;career development;Cell Nucleus;Censuses;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Trials Design;Collaborations;Communities;Critiques;Development;Devices;Disabilities experience;disability;Disabled Children;Disabled Persons;disadvantaged background;Disease;Disparity population;education research;Educational workshop;Enrollment;Ensure;equity, diversity, and inclusion;Evaluation;experience;Expert Opinion;Exposure to;Extramural Activities;faculty mentor;Feedback;Fostering;Funding;Future;Grant;Health;Health Technology;Healthcare;Home;Independent Living;Individual;Infant;Injury;innovation;insight;Institution;interdisciplinary collaboration;Intervention;K-Series Research Career Programs;Knowledge;Learning;Life;Lifelong disability;medical specialties;Mentors;Mentorship;Minority;next generation;older adult;Older Population;peer;Peer Review;Persons;Population;Postbaccalaureate;Postdoctoral Fellow;Preparation;Problem Solving;Process;Productivity;Professional Competence;programs;Qualifying;Quality of life;recruit;rehabilitation research;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Training;retention rate;Risk;role model;Scientist;Self Care;skills;sound;success;Survivors;Technology;Testing;Training;Training Programs;Trauma;Underrepresented Populations;underserved minority;Underserved Population;United States;United States National Institutes of Health;Woman;Work;World Health Organization;Writing

PROJECT_TITLE: Intensive Rehabilitation Research Grant Writing Workshops in the United States (TIGRR)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: One in ten Americans are affected by chronic kidney disease. Chronic kidney disease is a gene environmental disease. Critical cell type(s) and pathway(s) responsible for disease development remains unknown limiting kidney disease understanding and new therapeutics development.

PI_NAMEs: SUSZTAK, KATALIN  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Address;Affect;Agreement;Alternative Splicing;American;ATAC-seq;Award;Binding;Candidate Disease Gene;Catalogs;causal variant;cell type;Cells;Chromatin;Chromatin Structure;Chromosome Mapping;Chronic Kidney Failure;Code;Data Set;Development;diabetic;Diagnostic;Disease;disease diagnostic;disease-causing mutation;disorder risk;Distant;DNA Sequence;Epigenetic Process;epigenome;Equipment and supply inventories;Ethnic Origin;follow-up;Funding;Gene Dosage;Gene Expression;Gene Expression Profiling;gene expression variation;Genes;genome wide association study;genome-wide analysis;Genotype;Heritability;Human;improved;Inherited;innovation;Kidney;Kidney Diseases;knockout gene;Lead;Link;Mendelian randomization;Methods;Modeling;Mus;novel;novel therapeutics;Organ;Pathogenesis;Pathway interactions;Phenotype;Predisposition;Quantitative Trait Loci;Renal Hypertension;Renal tubule structure;risk variant;RNA Splicing;Role;Sample Size;Sampling;Scientist;Secondary to;success;Therapeutic;therapeutic development;Tissue Banks;Transcript;transcription factor;Translating;Untranslated RNA;Variant;Work

PROJECT_TITLE: Epigenetics of Chronic Kidney Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as cancer treatment with chemotherapeutic drugs induces progressive, long-lasting adverse effects on cognitive function in 30 to 50% of patients, yet its pathogenesis is not well understood. Increasing clinical and experimental evidence suggest that chemotherapeutic agents cause cerebral vascular damage, which impairs cerebral blood flow and vascular responses contributing to chemotherapy-induced cognitive impairment. The discovery of the cellular mechanisms responsible for decreased cognitive capacity after cancer treatment is ultimately expected to enhance understanding of the pathogenesis of the disease and will lead to the development of novel therapeutic interventions for prevention; thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burdens of cancer.

PI_NAMEs: CSISZAR, ANNA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Abbreviations;Acceleration;Address;Adverse effects;Affect;age acceleration;Aging;attentional control;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;Brain;Cancer Burden;Cancer Patient;Cancer Survivor;cancer therapy;Cell Aging;Cells;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;chemobrain;chemotherapeutic agent;chemotherapy;Clinical;clinically relevant;Cognition;cognitive capacity;cognitive function;contrast imaging;Data;density;Detection;Development;Disease;DNA Damage;Endothelial Cells;Endothelium;executive function;experience;Exposure to;Functional Magnetic Resonance Imaging;Ganciclovir;genetic manipulation;Hemorrhage;Impaired cognition;Impairment;improved;innovation;insight;Intervention;irradiation;Knowledge;Laser Speckle Imaging;liposomal delivery;Long-Term Survivors;loss of function;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Memory;Microvascular Dysfunction;Mission;Modality;mouse model;Mus;neuroinflammation;Neurons;neurovascular;neurovascular coupling;novel;novel therapeutic intervention;Outcome;Oxidative Stress;Paclitaxel;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Pre-Clinical Model;prevent;Prevention;preventive intervention;Process;programs;Proteins;Protocols documentation;Public Health;Publishing;Quality of life;red fluorescent protein;Regulation;Reporter;Research;Resistance;response;Role;senescence;senescent cell;senolytics;Series;spatiotemporal;Symptoms;Testing;Therapeutic;Treatment outcome;two-photon;United States National Institutes of Health;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Diseases;Vasodilator Agents;Work

PROJECT_TITLE: Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Spinal Cord Injury (SCI) is damage to the spinal cord that results in permanent loss of function such as mobility or feeling below injury. There are approximately 300,000 Americans living with SCI, and approximately 20,000 of those injured are Veterans (data from Paralyzed Veterans of America). Thus, care and treatment of spinal cord injured veterans is important to the VA patient care mission. This proposal is to elucidate mechanisms underlying the poor regenerative capacity of the forelimb CST and to test experimental approaches for enhancing forelimb CST regeneration that we hypothesize will further improve forelimb functional recovery after SCI. The success of this project will benefit those veterans and civilians who suffer SCI.

PI_NAMEs: LU, PENGZHE  (contact)

PROJECT_TERMS: American;Antisense Oligonucleotide Therapy;Automobile Driving;Axon;axon growth;axon regeneration;Bilateral;Brain;Caring;Cells;Central Nervous System;Cervical;Cervical spinal cord injury;CISH gene;Clinical;clinically relevant;combinatorial;Contusions;Corticospinal Tracts;Data;designer receptors exclusively activated by designer drugs;Distal;Embryo;experience;Experimental Designs;Feeling;Forelimb;functional improvement;Funding;Gene Expression Profile;Genes;Genetic;Grant;Grant Review;Growth;Hand functions;Hindlimb;Human;improved;injured;Injury;knock-down;Knowledge;Label;Life;loss of function;Mission;Modeling;Molecular;Motor;motor control;Mus;Natural regeneration;Nerve Regeneration;nerve stem cell;neural network;Neurons;Nonpenetrating Wounds;Paralysed;Patient Care;prevent;PTEN gene;Quadriplegia;Rattus;Recovery;Recovery of Function;Recovery Support;regenerative;Regenerative capacity;Rehabilitation therapy;Research;response to injury;Signal Transduction;Site;skills;small hairpin RNA;Spinal Cord;Spinal cord injury;stem cells;success;Synapses;System;Testing;Training;transcriptome sequencing;transmission process;Tumor Suppressor Genes;Veterans;Viral;Work

PROJECT_TITLE: Enhancing Forelimb Recovery by Promoting Forelimb Corticospinal Tract Regeneration after Spinal Cord Injury

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: Project Narrative: Current 2D cell culture systems do not reliably model nor predict the physiopathology of Alzheimer’s Disease, an irreversible and incurable disorder of multiple tissues in the brain that affects millions of Americans. This project aims to construct a 3D dynamic brain tissue (mini-brain in a dish) integrated with patient stem-cell derived brain cells, to validate AD physiopathology, including extracellular plaques, intracellular fibers tangles, vessel abnormality, and an overactive immune response. This in vitro platform can be used to accelerate drug discovery and screening.

PI_NAMEs: YUN, YEOHEUNG  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 3-Dimensional;abeta accumulation;absorption;Acceleration;Affect;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Model;Animals;Astrocytes;attenuation;beta-site APP cleaving enzyme 1;Biological Assay;Biological Models;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;Brain;brain cell;Brain Diseases;brain tissue;Cell Culture System;Cells;Cerebrovascular system;Characteristics;Chronic;Clinical Trials;clinically relevant;cognitive function;Communities;Complex;Coupled;Data;Dementia;Deposition;Disease;disease model;Disease Progression;drug discovery;Drug Screening;Early Onset Familial Alzheimer's Disease;efficacy testing;Endothelial Cells;Endothelium;Environment;experience;extracellular;Extracellular Matrix;Failure;familial Alzheimer disease;Family suidae;Fiber;Functional disorder;Generations;Genes;gliovascular;Human;Hyperactivity;imaging capabilities;Immune;immune function;Immune response;Immune system;Impaired cognition;In Vitro;in vitro Model;in vivo;in vivo Model;induced pluripotent stem cell;induced pluripotent stem cell technology;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;Investigational Drugs;Knowledge;Measures;Mediating;Membrane;Microfluidics;Microglia;microphysiology system;Modeling;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;neurotoxicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Perfusion;personalized medicine;Persons;Physiology;Pilot Projects;Play;Positioning Attribute;presenilin-1;presenilin-2;recruit;Reproducibility;Research;response;Scientist;Senile Plaques;Slice;stem cells;Structure;Study models;System;Systems Development;T-Lymphocyte;tau aggregation;tau-1;Testing;Therapeutic Intervention;three dimensional cell culture;Tissue constructs;Tissues;Toxic effect;Transportation;Universities;Validation;Western World

PROJECT_TITLE: Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influenceon gliovasculature and immune system


NIH_SPENDING_CATS: Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE (PROJECT NARRATIVE) Mutations in the FOXF1 gene locus are associated with alveolar-capillary dysplasia with misalignment of pulmonary veins, a lethal lung developmental disorder with no cure. This project aims to uncover the molecular mechanism underlying FOXF1-mediated abnormalities in alveolar endothelial cell subtypes, and the disrupted endothelial-epithelial interactions during lung development. If successful, the proposed studies will uncover the FOXF gene regulatory network in human lung, and provide new therapeutic targets to re-establish normal alveolar-capillary interface in various lung developmental disorders.

PI_NAMEs: GU, MINGXIA  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Affect;Alveolar;Alveolar capillary dysplasia with misalignment of pulmonary veins;ATAC-seq;Benchmarking;Blood capillaries;Blood Vessels;Cell Communication;Cell Nucleus;cell type;Cells;Coculture Techniques;Data;Data Set;Deletion Mutation;Development;Disease;Distal;Endoderm;Endothelial Cells;endothelial stem cell;Endothelium;Epithelial Cells;epithelial stem cell;Epithelium;Etiology;Event;FOXF1 gene;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Genes;genetic signature;genomic locus;Goals;Heterozygote;Homeostasis;Human;human induced pluripotent stem cells;improved;In Vitro;induced pluripotent stem cell;injured;Injury;insight;Lead;Ligands;Lung;lung development;lung developmental disorder;Maps;Mediating;Mesoderm;Modeling;Molecular;Mus;mutant;mutant mouse model;Mutation;new therapeutic target;novel;Organoids;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Perfusion;Phase;Play;Point Mutation;Population;postnatal;postnatal human;prenatal;prevent;PTEN gene;PTK2 gene;public health relevance;receptor;receptor binding;Regulation;repaired;RNA;Role;Sampling;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;stem cell organoids;Structure of parenchyma of lung;System;Testing;TGFB2 gene;TGFBR2 gene;transcription factor;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Variant;Vascularization

PROJECT_TITLE: Elucidating the FOXF1 gene regulatory network in human alveologenesis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE Bacteriophages (phages) are believed to reduce the density of bacterial pathogens in their environments and therefore transmission of disease, and also to impact the evolution of bacteria, perhaps contributing to the emergence of new strains. Yet, there is scant evidence to support these claims. To reveal if and how phages can play these important roles, we will investigate the impact of four phages that are commonly associated with Vibrio cholerae on bacterial virulence, transmission, and strain evolution.

PI_NAMEs: CAMILLI, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Adsorption;Animals;Area;Bacteria;Bacteriophages;Biological Assay;biotypes;Cells;Cholera;Cholera Toxin;Clustered Regularly Interspaced Short Palindromic Repeats;contaminated water;Cyclophosphamide;Data;deep sequencing;density;diarrheal disease;Disease;disease transmission;DNA;Environment;Evolution;experimental study;Fiber;fitness;Gastrointestinal tract structure;Genes;Genome;Household;In Vitro;Infant;Infection;Life Cycle Stages;Lytic;Measures;Modeling;Mus;mutant;Oral;Oryctolagus cuniculus;pathogen;Pathogenesis;pathogenic bacteria;Phenotype;Plaque Assay;Play;Population;Population Sizes;Predatory Behavior;prevent;Production;Prophage Inductions;Prophages;prophylactic;Publishing;Role;Small Intestines;Symptoms;Tail;Testing;Time;Toxin;transmission process;Vibrio cholerae;Virulence;Virulence Factors;Virulent;Virus;Water;waterborne;waterborne pathogen

PROJECT_TITLE: Impact of Bacteriophages on Virulence and Transmission of Vibrio cholerae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-B(02)]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Perinatal medicine and biology has major public health consequences with the growing recognition that perinatal life is a major determinant of disease in adult life. The PRS Young Investigator Program enhances and accelerates the development of young investigators in the field of perinatal medicine and biology through grantsmanship, communication skills, and networking opportunities. This means we are helping ensure a future pool of outstanding physician-scientists and basic-scientists to improve health and disease during the perinatal period, consistent with the mission of NIH.

PI_NAMEs: ROZANCE, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TITLE: Perinatal Research Society Annual Meeting

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative The Center for Multiparametric Imaging of Tumor Immune Microenvironments (C-MITIE) will define physical and molecular barriers to effective anti-tumor immune responses and therapies. As an integrated team we will advance and develop state-of-the-art live cell and tissue optical imaging platforms and quantitative analyses to define the principal physical barriers that limit effective anti-tumor immunity and immunotherapy. This will facilitate design criteria for novel immunotherapy regimens and next-generation cell-based immunotherapies for cancer patients.

PI_NAMEs: ELICEIRI, KEVIN WILLIAM;PROVENZANO, PAOLO  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-tumor immune response;Behavior;Biological Models;biophysical model;Cancer Biology;cancer imaging;cancer immunotherapy;Cancer Patient;cancer therapy;cell behavior;Cell Physiology;Cells;cellular engineering;cellular imaging;Cellular immunotherapy;Clinical;Collaborations;Complex;Computer Analysis;crosslink;Data;Data Analyses;data modeling;design;Development;Dimensions;Effectiveness;engineered T cells;Engineering;Environment;experience;Extracellular Matrix;Fingerprint;fluorescence lifetime imaging;Genetically Engineered Mouse;Genome engineering;Goals;Image;imaging platform;Imaging technology;immune checkpoint blockade;immune function;Immune response;Immunosuppression;Immunotherapy;improved;Infrastructure;Institution;instrumentation;Leadership;Malignant neoplasm of brain;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;member;Microfabrication;Microscopy;migration;Modeling;Molecular;molecular imaging;multi-photon;multimodality;multiparametric imaging;multiphoton microscopy;nanofabrication;neoplasm immunotherapy;new technology;next generation;novel;Oncology;optical imaging;Optics;Persons;Play;Prognosis;Publishing;Regimen;Research;Resolution;response;Seminal;Solid Neoplasm;Spectrum Analysis;Sum;T cell infiltration;T cell therapy;T-Lymphocyte;Technology;technology development;Testing;Time;Tissue imaging;Tissues;tool;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;virtual;Vision;Work


ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: Project Narrative Loud sounds can damage your ears and lead to sensorineural hearing loss (SNHL). Because of the environments in which military personnel operate, they are more likely to suffer service-related hearing losses than non-military populations. The mechanism of SNHL is poorly understood because how loud sounds reach our inner ear, and how the damage they inflict affects our hearing is not well described. We propose a signal- processing approach along the entire auditory pathway to resolve this. Combined measurements in the ear canal, within the cochlea, and at the brain will distinguish between noise-induced sensory and neural HL. This greatly enhances rehabilitation strategies that alleviate the burden of hearing loss. The proposed research will provide basic knowledge on how the ear works and explain what changes due to noise-induced damage. It also contributes to the diagnosis of sensory or neural loss, which directly benefits military personnel, Veterans, and civilians suffering from SNHL.

PI_NAMEs: DONG, WEI  (contact)

PROJECT_TERMS: Affect;American;Animals;Apical;Auditory;auditory pathway;Auditory system;Auditory Threshold;Back;blast exposure;Brain;Calibration;cell injury;Cessation of life;Clinic;Clinical;clinical application;clinical diagnosis;Cochlea;Complex;Coupling;design;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Differential Diagnosis;Ear;Elements;Environment;experimental study;External auditory canal;Foundations;Frequencies;Gerbils;Goals;Hair Cells;Health;Hearing;hearing impairment;Hearing Tests;Human;Impairment;improved;Individual;individual response;Injury;Intervention;Knowledge;Labyrinth;Link;Loudness;Maps;Measurement;Measures;Mechanics;Medical;Military Personnel;Modeling;Monitor;Motion;Nervous System;neural;neural hearing loss;Neurons;Noise;noise exposure;normal hearing;notch protein;novel;Optical Coherence Tomography;otoacoustic emission;Outer Hair Cells;personalized diagnostics;Physiological;Population;rehabilitation strategy;Rehabilitation therapy;Research;response;Sensorineural Hearing Loss;Sensory;Services;signal processing;Signal Transduction;sound;Speech;Speech Perception;Structure;Structure-Activity Relationship;System;Techniques;Testing;Time;Translating;Traumatic Brain Injury;Veterans;Work

PROJECT_TITLE: Signal Processing Along the Auditory Pathway:  Changes Following Noise Exposure

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy

PI_NAMEs: ODDE, DAVID J. (contact)

PROJECT_TERMS: Adoption;Beds;Biological;Biomedical Engineering;Cancer Patient;Cancer Survivor;Clinical;Collaborations;Communication;Cultural Backgrounds;dissemination strategy;diversity and equity;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;experience;Fellowship Program;Foundations;Friendships;Gender;Goals;healing;imaging facilities;improved;innovation;insight;Investments;Leadership;Life Experience;Malignant Neoplasms;meetings;Midwestern United States;multiparametric imaging;Outcome;patient advocacy group;Process;programs;Race;Research;Research Personnel;Resources;Societies;success;technological innovation;Technology;technology development;Testing;tumor microenvironment;tumor-immune system interactions;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: ELICEIRI, KEVIN WILLIAM (contact)

PROJECT_TERMS: 3-Dimensional;Algorithms;Animal Model;Architecture;Beds;Binding;Biochemical;cancer imaging;Cancer Model;candidate marker;cell behavior;Cell model;cell type;Cells;Cellular Morphology;Collaborations;Collagen;Collagen Fiber;Communities;Computer Analysis;Computer software;Computing Methodologies;crosslink;Data Analyses;design;Development;Dimensions;Extracellular Matrix;fabrication;Fiber;Fluorescence;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;fluorophore;Foundations;Generations;Glioblastoma;Goals;human data;Image;imaging approach;imaging biomarker;imaging modality;imaging platform;Imaging technology;Immune;immune cell infiltrate;improved;In Vitro;Individual;insight;Investigation;Label;Machine Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Metabolic;Metabolism;Methods;microscopic imaging;Minnesota;Mission;Modeling;Molecular;multi-photon;multiparametric imaging;multiphoton microscopy;neoplasm immunotherapy;new technology;open source;Optical Coherence Tomography;optical imaging;Photochemistry;physical property;Prognosis;Protocols documentation;Research;Research Personnel;Resources;Role;second harmonic;second harmonic generation imaging;Signal Transduction;Solid Neoplasm;Sorting;Spectrum Analysis;T-Lymphocyte;Techniques;Technology;technology development;Testing;Time;Tissue Model;Tissues;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Universities;Wisconsin

PROJECT_TITLE: TECH Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative We have proposed that it is necessary to eradicate disseminated tumor cells (DTCs) in distant tissues like bone marrow in order to prevent breast cancer metastasis. We have shown that DTCs are resistant to chemotherapy because of the niche that they occupy, and found that chemotherapy triggers robust changes within this niche that, paradoxically, actually protect DTCs from therapy. We propose to identify and target this response in order to deprive DTCs of pro-survival signals, thus preventing their ability to cause lethal complications in the future.

PI_NAMEs: GHAJAR, CYRUS M (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Adjuvant;Affect;Animals;ataxia telangiectasia mutated protein;Benchmarking;Blood Vessels;Bone Marrow;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Prevention;breast cancer survival;Cell Cycle;Cell Survival;Cell Therapy;Cells;Chemoprotective Agent;chemotherapy;Cytoprotection;Data;Distant;DNA Damage;Endothelial Cells;Endothelium;Estrogen receptor positive;Evolution;extracellular;Future;genotoxicity;Goals;hormone therapy;improved;in vivo;Individual;innovation;Integrin Inhibition;Integrins;knock-down;Left;Ligands;Liver;Lung;Malignant Breast Neoplasm;Measures;Mediating;metastasis prevention;Metastatic Neoplasm to the Bone;Modeling;Mus;Mutagens;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;NTN1 gene;Output;Patients;Phase;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;protective factors;Protein Array;Recurrence;Regimen;Resistance;response;Risk;Role;Safety;sensor;Signal Pathway;Signal Transduction;Site;Source;stem;Stereotyping;Stress;synergism;targeted treatment;Testing;Therapeutic;therapy resistant;Tissues;Toxic effect;Transgenic Organisms;Translating;Up-Regulation;Vascular Cell Adhesion Molecule-1;Vascular Endothelium;vascular factor;Vertebral column;von Willebrand Factor;Work

PROJECT_TITLE: Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Evidence suggests that in sub-Saharan Africa myocardial infarction (MI) is associated with very high mortality, but locally-appropriate interventions to improve uptake of evidence-based care are lacking. This study will identify barriers to MI care, develop a tailored multicomponent intervention to improve care, and assess the feasibility, acceptability, and preliminary effectiveness of this tailored intervention. The results from this study will lead directly to clinical trials to test interventions to reduce mortality from myocardial infarction in resource-limited domestic and global settings.

PI_NAMEs: HERTZ, JULIAN T (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accident and Emergency department;Acute myocardial infarction;Africa South of the Sahara;Aspirin;barrier to care;burden of illness;Cardiovascular Diseases;Cardiovascular system;career;career development;Caring;Cause of Death;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Consolidated Framework for Implementation Research;Data;Death Rate;design;Diagnosis;Diagnostic;Disease;Early Diagnosis;Early treatment;effective intervention;Effectiveness;Effectiveness of Interventions;Electrocardiogram;Emergency Department patient;Emergency Department Physician;Emergency Medicine;Emergency Situation;evidence base;Evidence based intervention;experience;Failure;Feedback;Future;global health;Goals;Grant;Health care facility;implementation research;implementation science;improved;Intervention;Interview;Investments;Knowledge;Lead;Localized Disease;low and middle-income countries;Low income;Maps;Medical center;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;multi-component intervention;Myocardial Infarction;Observational Study;Operative Surgical Procedures;Outcome;Patient Education;Patients;Physicians;Positioning Attribute;Process;professor;Program Development;prospective;protocol development;Provider;public health relevance;Research;Research Infrastructure;Research Methodology;Research Personnel;Resource-limited setting;Resources;routine screening;skill acquisition;skills;Surveys;Symptoms;System;Tanzania;Testing;therapy development;Training;treatment guidelines;Treatment Protocols;Troponin;Underserved Population;United States;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Developing an intervention to improve quality of myocardial infarction care in northern Tanzania


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: PROVENZANO, PAOLO  (contact)

PROJECT_TERMS: Architecture;Automobile Driving;Behavior;Biophysical Process;cancer imaging;Cancer Prognosis;cell behavior;cell motility;Cell Physiology;cell transformation;Cells;cellular engineering;chemical reduction;Chemicals;Clinical;cohort;Combined Modality Therapy;Complex;Coupled;Cues;Cytotoxic T-Lymphocytes;design;Desmoplastic;Disease;Disease Outcome;engineered T cells;Engineering;Environment;Experimental Models;experimental study;Extracellular Matrix;Fingerprint;fluorescence lifetime imaging;Generations;genetically modified cells;Genome engineering;Goals;Halofuginone;Image;imaging study;Immune;immune checkpoint blockade;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Infusion procedures;intravital imaging;KPC model;Link;Machine Learning;Malignant Epithelial Cell;Malignant Neoplasms;Maps;mathematical model;Mechanics;Mediating;Microtubules;migration;Molecular;multi-photon;multimodality;multiparametric imaging;Multiplexed Ion Beam Imaging;Myelogenous;Myeloid-derived suppressor cells;novel;optical imaging;Optics;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;Phenotype;physical property;Population;pre-clinical;Radiation therapy;Research;Resistance;Resolution;response;rho;Role;Sampling;second harmonic;Signal Transduction;Slice;Solid Neoplasm;Spectrum Analysis;Speed;Structure;success;Survival Rate;System;T cell infiltration;T cell therapy;T-Lymphocyte;targeted treatment;technology development;Testing;Tissues;Treatment Efficacy;tumor;tumor microenvironment;Tumor Volume;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Research Testbed 1


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Ethical, efficient sharing of federated genomic and health related data will transform disease diagnosis and treatment, reveal new patterns in human biology, allow researchers to expand studies of cancer and common disease associations to less common and more detailed analyses, strengthen genomic variant interpretation in rare diseases, and enable more informed clinical decisions. However, lack of interoperability—both technical and regulatory—has resulted in data that is siloed by institution, country, and disease area, locking away their potential to contribute to research and medicine. The Global Alliance for Genomics and Health (GA4GH) will convene the research and healthcare communities to agree on common methods for collecting, storing, transferring, accessing, and analyzing data in order to overcome these barriers, enable broad data sharing that transcends the boundaries of any single institution or country, and fulfill the human right of everyone to benefit from the advances of genomic research, as mandated by the Universal Declaration of Human Rights (Assembly 1948).

PI_NAMEs: REHM, HEIDI L (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Adopted;Adoption;Advanced Development;advanced system;Agreement;Applications Grants;Area;Award;Clinical;clinical care;Clinical Data;cloud based;cohort;Commercial Sectors;Communication;Communities;Community Health;Complex;Computer software;cost;Country;Data;data exchange;data modeling;Data Set;data sharing;Development;Disease;disease diagnosis;Documentation;drug response prediction;Ecosystem;Educational workshop;Ensure;Ethics;experience;federated data;file format;Funding;Future;Genes;genetic variant;Genome;genomic data;Genomic medicine;Genomics;Guidelines;Health;health data;Health system;Healthcare;healthcare community;Human;Human Biology;human disease;Human Rights;Individual;Industry;innovation;Institution;International;interoperability;Learning;Link;Location;Malignant Neoplasms;Medicine;meetings;Methods;Mind;Mission;Ontology;Patients;Pattern;Persons;Policies;Precision Health;Rare Diseases;Research;Research Personnel;Resolution;Sampling;Secure;Software Engineering;Specific qualifier value;Stream;success;Systems Analysis;tool;Training;Transcend;uptake;virtual;webinar;Work

PROJECT_TITLE: The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Lung;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Pulmonary complications are the leading cause of mortality in patients with osteogenesis imperfecta (OI) and the mechanisms behind these complications, specifically reaction to environmental damage, are unknown and not well explored. This proposal will gain insights into the mechanisms causing OI lung insufficiency and completion of the aims will contribute to knowledge regarding the effect of abnormal extracellular matrix secretion and ER stress on lung cell differentiation and damage recovery as well as the effect of in vivo ER stress inhibition treatment. Importantly, our study will identify novel targets for future clinical therapies that could ameliorate OI lung abnormalities, for which there are presently no established treatments.

PI_NAMEs: ZIEBA, JENNIFER  (contact)

PROJECT_TERMS: Address;Affect;alveolar epithelium;Apoptosis;Basement membrane;Bleomycin;bone;Bone Diseases;bone fragility;Cell Communication;Cell Differentiation process;cell injury;Cell Physiology;Cell secretion;Cells;Chronic;Clinical;Coculture Techniques;Collagen;Collagen Gene;Collagen Type I;Communication;Defect;defined contribution;Deformity;Development;disability;Disease;endoplasmic reticulum stress;Environment;environmental stressor;Epithelial Cells;Exhibits;experimental study;Extracellular Matrix;Fibroblasts;Foundations;Fracture;Frequencies;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Histologic;Homeostasis;Impairment;improved;In Vitro;in vivo;Infection;insight;Knowledge;Lead;loss of function mutation;Lung;lung development;Lung Diseases;lung injury;Mesenchymal;Methodology;Methods;Modeling;Molecular;Molecular Chaperones;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;mutant;Mutation;Myofibroblast;novel;Organoids;Osteoblasts;Osteogenesis Imperfecta;Patients;Perinatal mortality demographics;Phenotype;Population;Population Distributions;postnatal;postnatal development;Predisposition;Proliferating;Proteins;pulmonary function;Pulmonary Valve Insufficiency;Reaction;Recovery;Reporting;RNA;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure;Structure of parenchyma of lung;Therapeutic;Tissues;Validation;Work

PROJECT_TITLE: Investigating pulmonary complications due to abnormal collagen/ER stress in Osteogenesis Imperfecta


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

PROJECT_TERMS: Adult Glioblastoma;Architecture;Biochemical;biophysical model;Blood;Bone Marrow;Brain;Brain Neoplasms;brain tissue;cancer cell;CD44 gene;CD8-Positive T-Lymphocytes;cell killing;cell motility;Cells;cellular imaging;Cellular Morphology;chemotherapy;Collagen Fiber;Data;Development;Effectiveness;Engineering;experimental study;Extracellular Matrix;Family;Fluorescence;fluorescence imaging;Fluorescence Resonance Energy Transfer;Generations;glial activation;Glioblastoma;Guanosine Triphosphate Phosphohydrolases;Human;human disease;Image;imaging modality;Immune;Immune response;Immunocompetent;Immunologics;Immunosuppression;Individual;Integrins;Investigation;Macrophage;Macrophage Activation;Malignant - descriptor;Malignant Neoplasms;Measurement;Measures;mechanical force;Mechanics;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;Metabolic;Metabolism;Microglia;migration;Modeling;models and simulation;Molecular;mouse model;multiparametric imaging;NADH;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Optical Coherence Tomography;Phenotype;Phosphotransferases;Positioning Attribute;pre-clinical;predictive modeling;Radiation;Research;rho;Role;sensor;Signal Transduction;Sleeping Beauty;src-Family Kinases;Structure;System;T-Lymphocyte;temozolomide;Testing;therapy development;Tissues;Traction;Transposase;tumor;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;unpublished works;Visualization;white matter;Wild Type Mouse

PROJECT_TITLE: Research Testbed 2


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The ability to sense environment temperature is essential for life. Dysfunction in cold sensation leads to inflammatory and neuropathic cold allodynia. The proposed work will provide novel insights into the molecular and neural mechanisms of cold sensation and its related neurological disorders.

PI_NAMEs: DUAN, BO ;XU, SHAWN  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Afferent Neurons;allodynia;Animals;Behavior;Behavioral;Biology;Caenorhabditis elegans;Calcium;Candidate Disease Gene;Categories;Cells;Central Nervous System;Chemicals;cold temperature;conditional knockout;Cues;Data;design;Detection;Electrophysiology (science);Environment;Esthesia;Family;Fishes;Functional disorder;Generations;Genetic;Genetic Models;Genetic Screening;Glutamate Receptor;Glutamates;Homologous Gene;Human;Image;Inflammatory;insight;interdisciplinary approach;Ion Channel Gating;kainate;knock-down;Knockout Mice;Life;Mammals;Mediating;model organism;Molecular;Molecular Genetics;Mus;mutant;N-terminal;Nematoda;Nervous System Disorder;neuromechanism;Neurons;Neuropathy;novel;Peripheral;Peripheral Nervous System;receptor;Research;response;RNA Interference;Role;screening;sensor;Sensory;Sensory Receptors;Signal Transduction;Synapses;System;Temperature;Temperature Sense;Testing;Time;tool;transmission process;Work

PROJECT_TITLE: An unexpected role of glutamate receptors in the peripheral nervous system

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

PHR: Advanced non-small cell lung cancer (NSCLC) accounting for 85% of lung cancer is a highly aggressive cancer with poor prognosis and short survival rate. The goal of this study is to characterize a novel and unique cancer stem cell (CSC) population in NSCLC progression and metastasis and dissect its regulatory mechanisms that can be harnessed for developing a novel effective strategy for targeting progression and metastasis of NSCLC and overcoming the resistance to current standard of care treatments. Our proposal represents a paradigm- shifting concept in that the successful implementation of our proposal will not only reveal new insight into CSC regulation leading to cancer progression and metastasis, but also offer a new strategy for targeting advanced NSCLC with metastasis.

PI_NAMEs: LIN, HUI-KUAN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Accounting;anti-PD-1;Attenuated;cancer cell;Cancer cell line;cancer initiation;Cancer Patient;cancer stem cell;cancer therapy;CD47 gene;Cell membrane;Cells;chemotherapy;Clinical;CRISPR/Cas technology;cytokine;Data;Drug resistance;empowerment;Endowment;Epidermal Growth Factor Receptor;Genetic;Goals;humanized mouse;Immune;immune checkpoint blockers;Immune Evasion;Immune signaling;Immunity;immunoregulation;Immunotherapy;Impairment;innovation;insight;Integral Membrane Protein;Knock-in Mouse;Knowledge;LATS1 gene;Ligands;Light;Lung Adenocarcinoma;lung cancer cell;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;mouse genetics;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Organoids;overexpression;patient derived xenograft model;Patients;PD-1/PD-L1;Phagocytosis;Phagocytosis Induction;pharmacologic;Phosphotransferases;Platinum;Population;Process;Prognosis;Property;Protein Family;Protein Phosphatase 2A Regulatory Subunit PR53;recruit;Regulation;Reporting;Resistance;resistance mechanism;response;Role;Sampling;Signal Transduction;standard of care;stem cell function;stem cell population;survival outcome;Survival Rate;targeted treatment;Technology;Testing;therapeutically effective;therapy resistant;Thrombospondin 1;transcriptomics;transmission process;tumor;Tumor Escape;tumor progression;Tumor Stem Cells;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Identification of a novel targetable cancer stem cell regulator promoting cancer progression and metastasis in non-small cell lung cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Overall: Translational Hearing Center The Translational Hearing Center will build a broad, critical mass of academic translational researchers to develop therapeutics that preserve or restore sensory function in genomic, medical and environmental settings known to cause hearing loss or vestibular deficits. This will accelerate translation of candidate therapeutics towards clinical trials in an increasingly wider range of etiologies that predispose individuals to a higher risk of hearing loss or vestibular deficits.

PI_NAMEs: STEYGER, PETER STEPHEN (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Academic achievement;Academic Medical Centers;Acceleration;Achievement;Address;Admission activity;Advisory Committees;Affect;age acceleration;aging population;Attenuated;Auditory;Auditory Perception;Auditory system;Award;base;Basic Science;Biological Assay;Biomedical Research;Biometry;boys;candidate identification;candidate validation;career;Center for Translational Science Activities;Centers of Research Excellence;Child;cisplatin induced hearing loss;Cities;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Development;Drug Delivery Systems;drug discovery;Drug Prescriptions;Drug Screening;Economic Burden;efficacy study;efficacy validation;Eligibility Determination;Ensure;Environment;Etiology;Evaluation Research;Exposure to;fall risk;Fetal Alcohol Spectrum Disorder;Fostering;Foundations;Funding;Funding Mechanisms;Future;Genetic Polymorphism;Genomics;Goals;Grant;Great Plains;Health;Health system;Hearing;hearing impairment;hearing loss phenotype;hearing loss risk;hearing preservation;Hearing problem;hearing restoration;high risk;Hospitals;Human;Impaired cognition;Income;Individual;Infant;Inflammation;Infrastructure;Institution;International;Intervention;Investigation;Investigational Drugs;Investigational New Drug Application;Labyrinth;Language;Lead;lead candidate;Life;life span;Malignant Neoplasms;Medical;Medical center;Mental Depression;Mentors;Mentorship;Military Personnel;Mitochondria;Multicenter Studies;multidisciplinary;Nebraska;Neonatal Intensive Care Units;neonate;Neural Pathways;Noise;Noise-Induced Hearing Loss;Occupational;ototoxicity;patient population;Peripheral;Persons;pharmacologic;Pharmacologic Substance;Phase;Pilot Projects;Population;preclinical study;preservation;Production;programs;psychosocial;Quality of life;Recreation;recruit;Rehabilitation therapy;Research;Research Activity;Research Personnel;Research Project Grants;Risk;safety study;Secure;Sensory;Services;skills;social;Social Interaction;socioeconomics;Study Section;success;Technology;Therapeutic;therapeutic candidate;Therapeutic Intervention;Translating;Translational Research;translational scientist;Translations;Universities;Vestibular dysfunction;Vestibular function;vestibular system;voucher;Withdrawal;working group

PROJECT_TITLE: Translational Hearing Center


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hearing Loss;Neurosciences

PROJECT_TERMS: Accountability;Advisory Committees;Biometry;boys;career;Centers of Research Excellence;Clinical Research;Clinical Trials;Collaborations;Data;Dedications;empowerment;Ensure;Environment;Evaluation;Extramural Activities;Feedback;Fees;Funding;Future;Goals;Hearing;hearing preservation;hearing restoration;Hospitals;Human Resources;improved;Information Dissemination;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Journals;Leadership;Manuscripts;Medical;Medical center;meetings;Mentors;Mentorship;Modeling;Monitor;Nebraska;novel therapeutic intervention;novel therapeutics;Office of Administrative Management;operation;Outcome;Participant;Peer Review Grants;Performance;Phase;Pilot Projects;Positioning Attribute;preclinical study;Principal Investigator;Productivity;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Services;Site;sound;Strategic Planning;Structure;success;symposium;Teacher Professional Development;tenure track;Translating;translational impact;Universities;Vestibular function;vestibular system;voucher;Work


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Overall Narrative Radiotherapy (RT) is frequently used to treat patients with a variety of cancers; however, despite our ability to target RT with sophisticated techniques, it can still lead to high rates of normal tissue toxicity that significantly affect patients’ quality of life. The exciting new modality of ultra-high dose rate radiotherapy (FLASH-RT) could help in alleviating these complications due to its reported ability to spare normal tissues while being equivalent in controlling tumor growth. We will test the overall hypothesis that FLASH RT with particle therapy (protons, carbon ions, or electrons) is superior to the same therapy delivered at standard dose rates, providing for the protection of normal tissues without compromising tumor control; thus, the overall goal of this P01 application is to complete pre-clinical studies, specifically focusing on sarcomas and lung and pancreatic cancers, aimed at addressing key gaps in knowledge regarding FLASH-RT to move it into human clinical trials.

PI_NAMEs: KOUMENIS, CONSTANTINOS  (contact);LIN, ALEXANDER

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Adverse event;Affect;Algorithms;Animals;Annual Reports;antitumor effect;Attention;barrier to care;beam dynamics;beamline;Belief;Biological;Biological Models;Biometry;biophysical properties;Blood Vessels;Bone structure;cancer cell;Cancer Patient;Canis familiaris;Carbon;Carbon ion;Cells;Chest;Clinic;Clinical;Clinical Trials;Collaborations;comparative efficacy;Comparative Pathology;Development;Dose;Dose Rate;dosimetry;Electrons;Ensure;Esophagus;Evaluation;Fibrosis;Genetic;Genetic Determinism;Goals;Growth;Heart;Human;Hypoxia;Image Analysis;immune cell infiltrate;Immunofluorescence Immunologic;improved;Inflammation;Infrastructure;Injury;International;Intestines;irradiation;Knowledge;Knowledge acquisition;Lead;Lung;lung injury;Lymphedema;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;Methodology;Modality;Modeling;Molecular;Monitor;mouse model;Mus;Nature;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;operation;Operative Surgical Procedures;Osteosarcoma;Oxygen;particle;particle therapy;Patients;Phase;Phase I/II Trial;Physics;Pre-Clinical Model;preclinical study;Procedures;programs;proton therapy;Protons;quality assurance;Quality of life;quantitative imaging;Radiation;Radiation Dose Unit;radiation mitigation;Radiation therapy;Radiation Toxicity;Radiation-Induced Cancer;Radiobiology;Reporting;Research;Research Design;Resources;response;Sample Size;Sarcoma;Scanning;Scheme;Schools;Second Primary Neoplasms;Services;Site;spatiotemporal;Speed;Stains;statistical service;stem cell population;success;symposium;System;systems research;Techniques;Technology;Testing;Therapeutic;therapy outcome;Time;tissue injury;tissue preparation;Tissues;tool;Toxic effect;TP53 gene;transcriptomics;Transgenic Mice;translational study;treatment planning;Trichrome stain method;tumor;Tumor Biology;tumor growth;Universities;Validation;Variant

PROJECT_TITLE: Translational Studies in FLASH Particle Radiotherapy


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Immunization;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: IgA nephropathy, the most common glomerulonephritis worldwide, leads to end-stage renal disease in up to 40% of the patients and reduces life expectancy by 10 years. A key feature of the disease is the development of pathogenic immune complexes formed between IgG autoantibodies and aberrantly glycosylated IgA1. In this proposal, we investigate the diversity and structure of these pathogenic autoantibodies with a long-term goal to provide a strategy for the development of disease-specific therapies.

PI_NAMEs: GREEN, TODD JASON (contact);NOVAK, JAN

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Affinity;Age;Amino Acid Sequence;Amino Acids;Antibody-Producing Cells;Antigen-Antibody Complex;Antigens;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune Diseases;Automobile Driving;Binding;Binding Sites;biobank;Biochemical;chronic autoimmune disease;Clinical;Clinical Research;Cloning;Complement;Complex;Coupled;Cryoelectron Microscopy;Crystallography;Data;Defect;Deposition;design;Development;Diagnosis;Disease;Disease Progression;DNA Sequence Alteration;Docking;Donor Selection;Drug Design;drug development;Elements;End stage renal failure;Epitopes;Ethnic Origin;Galactose;Generations;Genes;Germ Lines;Glomerulonephritis;Glycopeptides;Glycoproteins;glycosylation;Goals;high throughput screening;IGA Glomerulonephritis;IgA1;IgG autoantibodies;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunologics;improved outcome;in silico;Individual;inhibitor;Injury to Kidney;Kidney;Kidney Failure;Laboratories;Libraries;Life Expectancy;Methods;Minor;Modeling;Molecular;multidisciplinary;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Patient-Focused Outcomes;Patients;Phenotype;Polysaccharides;Population;prevent;Process;Production;Reagent;Recombinants;Research Personnel;Resolution;Sampling;screening;Serine;Serum;Severity of illness;Site;Site-Directed Mutagenesis;small molecule;Specificity;Structure;Surface;Surface Plasmon Resonance;Techniques;Testing;therapeutic target;tool;United States;X-Ray Crystallography

PROJECT_TITLE: Pathogenic Autoantibodies with Specificity for Aberrant Glycoproteins: Assessment of a Therapeutic Target in an Autoimmune Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Pancreatic cancer is a devastating malignancy with poor survival. Proton radiotherapy is a modality used for the clinical management of PanCa; however, its efficacy is limited primarily by incidental dose to critical organs including the small intestine. Project 1 of this P01 will test the ability of a new form of Proton Therapy which s delivered at ultra-fast dose rates (termed “FLASH” radiotherapy) to control tumor growth as well as Standard dose rate radiotherapy, while at the same time spare normal intestine from toxicity, thereby allowing for a higher dose and better control of PanCa.

PI_NAMEs: KOUMENIS, CONSTANTINOS  (contact)

PROJECT_TERMS: Acute;Allografting;antitumor effect;base;beta catenin;biophysical properties;Blood Cells;Blood Vessels;cadherin 5;Canis familiaris;Carbon;carcinogenesis;Cell Proliferation;Cells;Characteristics;Clinical Management;Clinical Trials;Columnar Cell;Coupled;Data;Development;Diagnosis;Disease;Dose;Dose Rate;Endothelial Cells;Endothelium;Epithelial Cells;epithelial stem cell;Epithelium;Exhibits;experimental study;Fibrosis;Fractionation;gastrointestinal;gastrointestinal epithelium;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Determinism;Genetically Engineered Mouse;Growth;Immune;Immune response;Immunotherapy;improved;Induction of Apoptosis;Inflammatory Response;Injury;Interferon Type II;intestinal crypt;intestinal epithelium;Intestines;Knock-out;Knockout Mice;LGR5 gene;Link;Liver;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;mouse model;Mus;Normal tissue morphology;novel;Organ;Pancreatic Adenocarcinoma;pancreatic neoplasm;particle;Play;progenitor;proton therapy;Protons;Publishing;Radiation therapy;Radiation Tolerance;Resectable;response;Role;Sampling;Sarcoma;Scanning;Scheme;senescence;Signal Transduction;single-cell RNA sequencing;Skin;Small Intestines;stem cell fate;stem cell population;stem cell proliferation;stem cells;Survival Rate;Testing;Text;Therapeutic;Time;Tissues;Toxic effect;TP53 gene;translational study;tumor;tumor growth;tumorigenesis;Unresectable;villin

PROJECT_TITLE: Project 1: FLASH vs. Standard radiotherapy for treatment of PDAC and sparing normal intestine tissues


NIH_SPENDING_CATS: Cancer;Lymphatic Research;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Project Narrative Radiotherapy is generally not used to treat sarcomas in the definitive (without surgery) setting due to the significant morbidity (skin toxicity, lymphedema, second cancers, bone fractures, etc.) associated with the high doses that would be required. FLASH proton therapy, which delivers high doses within less than a second, has the potential to spare normal tissues from injury; hence, our long-term goal is to translate FLASH into the clinic for use in human patients with soft tissue sarcomas. In the context of radiotherapy for sarcoma,this project will elucidate mechanisms by which FLASH spares normal tissues through investigations in mice, and it will determine the safety and efficacy of FLASH when used for treatment of dogs with osteosarcomas.

PI_NAMEs: BUSCH, THERESA M (contact)

PROJECT_TERMS: Abdomen;Acute;Adjuvant Therapy;Amputation;Anatomy;Attenuated;barrier to care;Blood Vessels;bone;Bone Tissue;Canis familiaris;Cells;chronic ulcer;Clinic;Clinical;clinical outcome assessment;Clinical Trials Design;clinically relevant;Data;design;Development;Disease;Dose;Dose Rate;efficacy study;Electron Beam;Excision;Fibrosis;Fracture;Future;Goals;Growth;Human;Implant;in vivo;Incidence;Inflammation;Inflammatory;Injury;Intestines;Investigation;irradiation;knock-down;Leg;Limb structure;Long-Term Survivors;Lymphedema;Malignant Neoplasms;Marrow;Modality;Modeling;Morbidity - disease rate;mouse model;Mus;Necrosis;Neoadjuvant Therapy;Normal tissue morphology;novel;Operative Surgical Procedures;Osteosarcoma;particle;Pathologic;Patients;Phase;phase 1 study;preservation;Process;Production;Protocols documentation;proton beam;proton therapy;Protons;radiation mitigation;Radiation therapy;Radiation Toxicity;Recovery;Regimen;Reporting;Risk;Safety;safety and feasibility;Sarcoma;Schedule;Second Primary Cancers;Second Primary Neoplasms;Severities;side effect;Skin;skin damage;soft tissue;Soft tissue sarcoma;standard of care;stem;Testing;Therapeutic;Therapeutic Index;Therapy trial;Time;tissue injury;Tissues;Toxic effect;TP53 gene;Transgenic Mice;Translating;translational study;tumor;Tumor Volume;Vascular Endothelial Growth Factor C;Whole-Body Irradiation;Work

PROJECT_TITLE: Project 2: Mitigation of radiation toxicity in treatment of sarcoma with FLASH vs. Standard dose rates


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Existing therapies for cardiac electrical rhythm disturbances (arrhythmias) face important limitations, motivating the search for novel therapeutic targets to support a more personalized approach to preventing arrhythmias in human patients. Our interdisciplinary and comprehensive studies are motivated by unexpected preliminary data identifying the two pore K+ channel TREK-1 as an ideal, although understudied, candidate for next generation “precision” therapeutics. We expect this project will define the functional role of TREK-1 in cardiac pathophysiology and open new therapeutic avenues for tuning cardiac excitability and reducing arrhythmia susceptibility in human patients

PI_NAMEs: HUND, THOMAS JEFFREY (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Adjuvant Therapy;Adrenergic Agents;Anti-Arrhythmia Agents;Arrhythmia;Automobile Driving;Biochemistry;Biomechanics;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cells;Cessation of life;Chronic;Chronic stress;Clinical Trials;Computer Models;Computer Simulation;cost;Cytoskeleton;Data;Defect;Development;druggable target;Electrophysiology (science);experimental study;Face;Fibrosis;Functional disorder;Genes;Genetic;Goals;Heart;heart preservation;Homeostasis;Human;Image;In Vitro;in vivo;Inherited;Intervention;Ion Channel;Ions;Knockout Mice;Link;Mechanics;Membrane;Modeling;Molecular;mouse model;multimodality;Mus;Muscle Cells;new therapeutic target;next generation;novel;novel strategies;novel therapeutics;Organ;Pathway interactions;patient tolerability;Patients;Permeability;personalized approach;pharmacologic;Polyunsaturated Fatty Acids;Population;Potassium Channel;potassium channel protein TREK-1;Precision therapeutics;Predisposition;preservation;pressure;prevent;Publishing;Reagent;Regulation;Regulatory Pathway;Reporting;response;Risk;RNA Splicing;Role;sensor;Signal Pathway;Signal Transduction;Spectrin;Stimulus;Stress;Testing;Therapeutic;Time;Tissues;Variant

PROJECT_TITLE: Role of TREK-1 in modulating cardiac excitability and arrhythmia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PI_NAMEs: ZUO, JIAN  (contact)

PROJECT_TERMS: Ally;Apoptosis;Award;Biological Assay;Biological Availability;boys;Cancer Center Support Grant;candidate validation;Cell Line;Chemical Structure;Chemicals;Cochlea;Collaborations;cost;Databases;Dedications;design;Disease;Dosage Forms;Drug Delivery Systems;drug development;drug discovery;Drug Kinetics;Drug Screening;drug use screening;Education;efficacy study;Eligibility Determination;Equipment;equipment acquisition;experience;Extramural Activities;Faculty;Fees;Funding;Genetic Transcription;Goals;Grant;Hearing;hearing impairment;Hearing problem;hearing restoration;High Pressure Liquid Chromatography;high throughput screening;Human Resources;in silico;In Vitro;in vivo;Individual;Industry;Institution;instrument;Intellectual Property;Laboratories;lateral line;Lead;Maps;Medical;Medical center;Mentors;Methodology;Modernization;Mus;Nebraska;neuromast;next generation;novel;novel therapeutics;otoprotectant;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;polypeptide;Preclinical Testing;prevent;programs;Reporter;Research;research clinical testing;Research Personnel;Research Project Grants;Research Support;Route;screening;Series;service delivery;Services;Small Business Innovation Research Grant;small molecule;Strategic Planning;Synthesis Chemistry;Testing;therapeutic candidate;Therapeutic Uses;Toxic effect;Training;Universities;voucher;Zebrafish

PROJECT_TITLE: Drug Discovery and Delivery Core