NIH_SPENDING_CATS: Nutrition;Obesity;Prevention

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Obesity affects more than one-third of the US population generating a need for novel interdisciplinary strategies to resolve growing obesity related negative health outcomes. Advanced mathematical methods play a critical role on numerous fronts in obesity research, from evaluating the effect of population-wide obesity prevention policy measures to monitoring participants during lifestyle intervention studies. The proposed course will develop connections between mathematical scientists and obesity researchers to address research challenges with novel quantitative approaches.

PI_NAMEs: ALLISON, DAVID B (contact);BROWN, ANDREW W;THOMAS, DIANA MARIA

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Active Learning;Address;Affect;analytical method;Applications Grants;Applied Research;Archives;Area;Behavioral Model;behavioral response;Big Data;Bilateral;Biomedical Engineering;Body Weight Changes;career;Case Study;Collaborations;Communities;Complex;computer science;Computer Simulation;Computer software;Consultations;Data;Data Science;Derivation procedure;design;Development;Diabetes Mellitus;Discipline;Disease;doctoral student;econometrics;Education;Educational Curriculum;energy balance;Engineering;Enrollment;Epidemiology;Ethics;experience;Faculty;Fostering;Funding;Genomics;Goals;Grant;Health;Health behavior;Hour;Individual;Informatics;Interdisciplinary Study;interest;Intervention Studies;investigator training;Language;Laws;Lead;Learning;learning materials;learning strategy;lectures;lens;lifestyle intervention;mathematical methods;mathematical sciences;Mathematics;Measures;meeting abstracts;meetings;member;Methodology;Methods;Modeling;Monitor;next generation;novel;Nutritional Study;Obesity;obesity prevention;Outcome;Participant;patient engagement;Peer Review;Persons;Physics;Play;Policies;Population;Postdoctoral Fellow;predictive modeling;Prize;Procedures;Process;Productivity;programs;Psychometrics;public health relevance;Publications;Reporting;Research;Research Personnel;Research Proposals;Resources;responsible research conduct;Role;role model;Scientist;senior faculty;sensor;statistics;Strategic Planning;success;System;Techniques;theories;Time;tool;Training;Training Programs;United States National Institutes of Health;Video Recording;Voice;web site

PROJECT_TITLE: The Mathematical Sciences in Obesity Research

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: BOYS TOWN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PI_NAMEs: WHITE, STUART F. (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;aged;American;Amygdaloid structure;Anxiety Disorders;Attention;Behavior;Behavior Disorders;behavior influence;Behavioral;Biological;Biological Markers;Biological Process;biological sex;brain circuitry;brain health;Child;Childhood;Clinic;cognitive control;Communities;Data;design;Development;Disease;emotion dysregulation;emotion regulation;Emotional;Endocrinology;Exhibits;Female;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hormonal;Hormones;Hydrocortisone;Impairment;improved;Intervention;Link;maladaptive behavior;male;Mediating;Mental disorders;Mental Health;Mission;Mood Disorders;National Institute of Mental Health;neural;neural circuit;Neurobiology;neuroimaging;Neurons;Neurophysiology - biologic function;novel;Outpatients;Parietal;Parietal Lobe;Participant;Patients;peer;Performance;Physiology;Prefrontal Cortex;Prevalence;Process;Protocols documentation;Psychiatric therapeutic procedure;Psychopathology;Puberty;puberty transition;recruit;Regulation;Research;Research Domain Criteria;Research Project Grants;response;Role;sex;Sex Differences;social;stem;Stimulus;stress disorder;Temporal Lobe;Testosterone;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Pubertal hormone levels differentially modulate the neural circuits implicated in emotion dysregulation in youth with psychopathology


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE We will examine the vestibular receptor morphology, neural physiology, and VOR response behavior in blast exposed animals during a long period of recovery. We wish to understand if/how low levels of single blast exposure result in vestibular damage and how such damage contributes to vestibular behavioral dysfunction. We believe these studies are significant, timely, and will help to provide key insights into blast related vestibular injury that produces problems with balance, visual stability, and dizziness in people.

PI_NAMEs: DICKMAN, J DAVID (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Affect;Age;Air Pressure;Anatomy;Animals;Automobile Driving;Bass;Behavior;Behavioral;behavioral response;behavioral study;blast exposure;Blast Injuries;Brain Stem;Cells;Clinical;Cochlea;common symptom;Devices;Discrimination;Disorientation;Dizziness;equilibration disorder;Equilibrium;Etiology;Exhibits;experience;experimental study;Exposure to;Eye Movements;Functional disorder;functional loss;gaze;Hair Cells;Head;Human;Injury;insight;Laboratories;Measures;Military Personnel;Modernization;Morphology;Motion;mouse model;Mus;Nature;neural;neural correlate;Neurons;Neurosciences;operation;otoconia;Partner in relationship;Patient Self-Report;Patients;Persons;Physiological;Physiology;pressure;Property;Public Domains;Questionnaires;receptor;Recovery;Reporting;Reproducibility of Results;Research;response;Rodent;Science;Semicircular canal structure;Shock;Societies;Source;spiral ganglion;Structure;Symptoms;System;Testing;Time;Trauma;Traumatic Brain Injury;Tube;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular nucleus structure;vestibular system;vestibulo-ocular reflex;Visual

PROJECT_TITLE: Vestibular System Function Following Blast Exposure


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: EAST LANSING

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This project will provide the first systematic and population-based documentation of primary care inequities faced by sexual minority people of color, an understudied population that experiences significant and persistent health disadvantages. Findings will contribute to the understanding of unique barriers to care among specific socially disadvantaged groups and the improvement of their access, quality, and equity of care. The project will inform evidence-based interventions in clinical practices and public health measures to reduce health care and health inequities at the intersection of sexual orientation and race/ethnicity.

PI_NAMEs: HSIEH, NING  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Understanding primary care utilization and barriers to care among sexual and racial/ethnic minority populations

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Recent studies have highlighted defects in insulin processing and granule maturation that are linked to all major forms of diabetes; however significant conceptual gaps remain in our fundamental understanding of the causes of beta-cell dysfunction. We hypothesize that Phosphatidylinositol transfer protein alpha (PITPNA) is a key regulatory node that is required to maintain proper insulin production, granule formation and secretion and that restoring PITPNA levels in islets of T2D subjects will reverse beta-cell dysfunction including impaired insulin secretion and ER stress. These studies aim to highlight restoration of PI4-P between intracellular membranes as an innovative approach for increasing granule maturation and secretion as well as reversing beta-cell failure in major forms of diabetes.

PI_NAMEs: POY, MATTHEW NG (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Beta Cell;Cell Death;Cell Fractionation;Cell membrane;Cell Physiology;Cells;Chronic;Cytoplasmic Granules;Data;Defect;Development;Diabetes Mellitus;diabetes pathogenesis;Docking;Endoplasmic Reticulum;endoplasmic reticulum stress;Exocytosis;Failure;Functional disorder;Heat shock proteins;Human;human subject;Hyperglycemia;Impairment;improved;Individual;innovation;Insulin;insulin granule;Insulin Resistance;insulin secretion;Intracellular Membranes;islet;Islets of Langerhans;knock-down;Link;LoxP-flanked allele;Membrane;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Oxidative Stress;Pancreas;Pathway interactions;pharmacologic;phosphatidylinositol 4-phosphate;Phosphatidylinositol Transfer Protein;Phosphatidylinositols;Phospholipids;Phosphorylation;prevent;Production;Proinsulin;restoration;Role;Secretory Vesicles;Structure of beta Cell of islet;Testing;trans-Golgi Network

PROJECT_TITLE: PITPNA in pancreatic beta-cell dysfunction and diabetes pathogenesis

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related

ORG_CITY: COLLEGE STATION

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant mortality and morbidity in immunocompromised populations including transplant and AIDS patients and the fetus in utero. Congenital CMV infection causes mental retardation, vision impairment and deafness in surviving newborn and there is no vaccine or intervention strategy. The research will evaluate the correlates of immunity/protection against cCMV by various vaccines strategies and utilize a novel gene knockout animal to determine the significance of type III IFN response.

PI_NAMEs: MCGREGOR, ALISTAIR  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;adaptive immune response;Amniotic Sac;Animal Model;Animals;Antibodies;Antigen Targeting;Antigens;Capsid;Cavia;Cell Line;cell type;Cells;Clinic;Complex;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;deafness;Development;Disease;Epithelial Cells;Epithelium;Evaluation;Fetus;Fibroblasts;Gene Expression;Glycoproteins;Guinea pig cytomegalovirus;guinea pig model;hearing impairment;Human;Immune;Immune response;Immunity;Immunocompromised Host;immunogenicity;Impaired cognition;improved;in utero;Individual;Infection;Innate Immune Response;insight;Interferons;Intervention;knockout animal;knockout gene;Macrophage;Mental Retardation;Morbidity - disease rate;mortality;mutant;neutralizing antibody;Newborn Infant;novel;pathogen;Pathogenesis;Pathogenicity;Patients;PDGFRA gene;Placenta;Population;Pregnancy;pregnant;Proteins;pup;receptor;Receptor Gene;renal epithelium;Research;Research Personnel;response;Risk;Route;Shapes;Study models;T cell response;timeline;Transplantation;trophoblast;unvaccinated;Vaccine Design;vaccine immunogenicity;vaccine strategy;vaccine trial;Vaccines;Viral;Virus;Virus Diseases;virus tropism;Visual impairment

PROJECT_TITLE: Development of a universal DISC vaccine strategy against congenital cytomegalovirus

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative The goal of this grant is to understand the mechanisms of conversion of 'repaired' wounds (fibrotic) into regenerative wounds in mammalian wound healing models and to understand the sometimes divergent regenerative capability of mice vs humans. This proposal is based upon our remarkable finding that ectopic Sonic Hedgehog signaling in 'repaired' hairless murine wounds can induce de novo hair follicle regeneration. The resulting proposal based on this finding has profound implications for understanding the regenerative and developmental biology of hair follicles as well as in defining future directions for skin regenerative medicine.

PI_NAMEs: ITO, MAYUMI  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Address;Adult;Agonist;appendage;beta catenin;Binding;bone morphogenetic protein receptors;Cell Differentiation process;Cells;ChIP-seq;Cicatrix;constitutive expression;Cues;Data;Dermal;Dermis;Development;Developmental Biology;Excision;experimental study;Failure;Fibroblasts;Fibrosis;Future;gain of function;Gene Modified;Genes;Genetic;Genetic Transcription;Goals;Grant;Hair follicle structure;healing;Human;human tissue;Hypersensitivity skin testing;Immunohistochemistry;improved;Injury;Investigation;Lead;Ligands;loss of function;Mammals;Mediating;Molecular Target;Mus;Myofibroblast;Natural regeneration;novel strategies;Outcome;Pathway interactions;Phenotype;Play;prevent;Process;Proliferating;Receptor Signaling;Recombinant Proteins;recombinant virus;regeneration potential;regenerative;regenerative biology;regenerative healing;Regenerative Medicine;Regulation;repaired;response;Role;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Skin;Skin Cancer;Skin graft;skin healing;skin regeneration;skin wound;smoothened signaling pathway;synergism;Testing;Tissues;tongue papilla;trait;transcriptome sequencing;Transfection;Up-Regulation;Viral;WNT Signaling Pathway;wound;wound environment;wound healing;Wound models;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Converting wound scar into healing with regeneration

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Current therapies for glomerular diseases including diabetic kidney disease are non-targeted and offer limited therapeutic benefit, which has created a tremendous unmet clinical need. In the current proposal, we show that enhancing levels of Rap1 activation in specific kidney cells, called podocytes, protects them from injury and mitigates disease progression. As a novel therapeutic approach, we have developed Rap1 agonist compounds that specifically target podocyte-enriched upstream Rap1 regulatory elements, allowing for potent Rap1 activation in podocytes but avoiding potential off-target effects.

PI_NAMEs: KAUFMAN, LEWIS  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Agonist;antagonist;autosome;Binding;Biological Process;Cell Culture Techniques;cell type;Chemicals;Chronic;Chronic Kidney Failure;Clinical;Congenital Nephrotic Syndrome;Diabetic Nephropathy;Disease;Disease Progression;effective therapy;Etiology;Family;Filtration;Focal and Segmental Glomerulosclerosis;gain of function;gain of function mutation;gene therapy;Genes;genetic regulatory protein;Goals;Grant;GTP Binding;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;human disease;Incidence;Inherited;inhibitor;injured;Injury;Kidney;kidney cell;Kidney Diseases;Knock-in Mouse;Lead;loss of function;Mediating;Modeling;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutation;Nature;Nephrotic Syndrome;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Play;podocyte;Predisposition;Process;RAPGEF2 gene;Regulatory Element;Regulatory Pathway;Renal glomerular disease;Reporting;Role;Signal Transduction;systemic toxicity;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Index;Transgenic Mice;Transgenic Organisms;Variant;Workplace;Zebrafish

PROJECT_TITLE: Podocyte-specific Rap1 agonism for treatment of glomerular disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Triple negative breast cancer (TNBC) and its aggressive subtype, metaplastic carcinoma (mBrCA), are over 4-fold more frequent in African Americans, and have high metastatic potential. This grant will address a novel mechanism of breast cancer metastasis by investigating how cytoplasmic phosphorylated EZH2 induces dissemination. Our studies, including work with unique tissue samples, may discover prognostic and diagnostic biomarkers of metastasis and reduce health disparities.

PI_NAMEs: KLEER, CELINA G (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: African;African American;African American population;African American Women;aggressive breast cancer;Antibodies;Automobile Driving;Biological Markers;Breast;breast cancer metastasis;breast cancer progression;Breast Carcinoma;cancer cell;cancer initiation;cancer subtypes;Carcinoma;cell motility;Clinical;clinically relevant;clinically significant;cohort;Complex;Cytoplasm;Data;Detection;diagnostic biomarker;diagnostic value;Distant Metastasis;Doxycycline;epigenetic silencing;epithelial to mesenchymal transition;ERBB2 gene;EZH2 gene;Focal Adhesions;follow-up;Frequencies;Funding;gene repression;Goals;Grant;Histone H3;histone methylation;Human;Immunohistochemistry;in vivo;innovation;Invaded;Investigation;knowledge integration;Laboratories;Link;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Mediating;Mesenchymal;Metaplastic Carcinoma;Metastatic breast cancer;Metastatic Prostate Cancer;Methodology;Methylation;Methyltransferase;Molecular;mouse model;mutant;Mutation;Neoplasm Metastasis;novel;novel diagnostics;Oncogenic;Organoids;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;patient biomarkers;Patients;Phenotype;Phosphorylation;Polycomb;Prognostic Marker;prognostic value;protein expression;Protein Methylation;Proteins;Proteomics;Race;racial disparity;Reagent;Reduce health disparities;Regulation;Reporting;Research Personnel;Role;Sampling;specific biomarkers;Testing;Threonine;Tissue Sample;Tissues;Transgenic Mice;Translating;triple-negative invasive breast carcinoma;tumor;Up-Regulation;Vinculin;White Women;Woman;Work

PROJECT_TITLE: Role of EZH2 in Breast Cancer Progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PUBLIC HEALTH RELEVANCE In this study we will compare short- and long-term harm reduction and abuse liability potential (i.e., withdrawal, craving, dependence) of a NSPS EC in African American exclusive EC, dual cig-EC, and exclusive cig users, characterize factors that predict who switches fully, partially, or not at all, and examine if harm reduction can be further enhanced by treating dual users with varenicline to eliminate cigarette smoking. Findings have the potential to support EC as a harm reduction strategy among a disparate group that arguably stands to benefit from it the most, contribute to the overall goal of reducing tobacco-related morbidity and mortality, and narrow the health disparity gap for AA smokers.

PI_NAMEs: NOLLEN, NICOLE L (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;abuse liability;Adopted;Adult;Adverse event;African American;Biological Markers;Characteristics;Cigarette;Cigarette Smoker;cigarette smoking;cigarette user;Clinical Trials;combustible cigarette;Counseling;craving;Data;Dependence;disparity gap;Disparity population;Electronic cigarette;electronic cigarette use;electronic cigarette user;experience;Failure;follow-up;Generations;Goals;Harm Reduction;Health;health disparity;high risk;Human;interest;Interleukin-9;Intervention;Knowledge;MMP8 gene;Morbidity - disease rate;mortality;Motivation;Nicotine;nicotine exposure;nicotine use;open label;Participant;Pattern;Perception;pharmacologic;Placebos;Population;Predictive Factor;primary endpoint;primary outcome;public health relevance;Randomized;Randomized, Controlled Trials;Research;respiratory;Respiratory Signs and Symptoms;side effect;Smoker;Smoking;Smoking History;social norm;Sodium Chloride;System;Testing;Tobacco;Toxicant exposure;varenicline;week trial;Withdrawal

PROJECT_TITLE: 4th Generation e-cigarettes in African American Smokers: Reducing Harm and Quitting Combustible Cigarettes in Dual Users


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: This project aims to delineate a novel regulatory loop of small RNA molecules, called microRNA that can impose regulation on gene expression, on B cells that are found in adipose tissue during obesity. Our team will test the idea that this circuit of regulation between microRNA and B cells in fat tissue is a major mechanism that controls the damaging inflammation. We postulate that understanding this process will lead to important therapeutic opportunities to treat metabolic disease that result from obesity.

PI_NAMEs: VELLA, ANTHONY T;ZHOU, BEIYAN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipocytes;Adipose tissue;adoptive B cell transfer;Antigen Presentation;Antigen Presentation Pathway;B-Cell Activation;B-Lymphocytes;Biological Assay;cell behavior;Cell Communication;Cell Physiology;cell type;Cells;Chronic;Clinical Research;Computational algorithm;Data;Development;Diabetes Mellitus;diet-induced obesity;Ectopic Expression;Fatty acid glycerol esters;Gene Expression;Gene Targeting;Genes;Goals;Health;Hematopoiesis;Homeostasis;humoral immunity deficiency;Immune;Immune response;Immunoglobulins;Immunologics;in vivo;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;Intervention;knock-down;Knock-out;Knowledge;leukemogenesis;Macrophage;Mature B-Lymphocyte;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;MicroRNAs;Modeling;Molecular;mouse model;Mouse Strains;Mus;novel;obese patients;Obesity;Organ;Outcome;overexpression;Pathway interactions;Patients;Physiological;Population;preclinical study;Process;Production;Publishing;Regulation;Reporter;Reporting;response;Risk;Role;screening;small hairpin RNA;Small RNA;stem cells;Stress;System;T-Lymphocyte;Testing;Therapeutic;Thinness;Tissues;transcriptome;transcriptome sequencing;translational potential;Work

PROJECT_TITLE: MiR-150 regulated adiose tissue B cells in obesity

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The cholecystokinin-B (CCK-BR) receptor becomes over-expressed in chronic pancreatitis, a condition that increases the risk for pancreatic cancer 8-fold. Strategies to reprogram the ‘at-risk’ pancreas and its microenvironment after pancreatitis to a normal phenotype may prevent the development of pancreatic cancer. This investigation will examine the mechanisms by which blockade of the CCK-BR with an antagonist, proglumide, affects 3 separate compartments involved pancreatic carcinogenesis including the epithelial cells, the stellate of fibroblasts, and the immune cells to render the pancreas less oncogenic and resume a normal phenotype.

PI_NAMEs: PIEROBON, MARIAELENA ;SMITH, JILL P (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Acinar Cell;Adult;advanced disease;Affect;antagonist;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;cell injury;cell motility;Cell Proliferation;cell type;Cells;Cessation of life;Characteristics;chemokine;chemokine receptor;Cholecystokinin A Receptor;Cholecystokinin B Receptor;Cholecystokinin Receptor;Chronic;chronic pancreatitis;Clinical;Collagen;Collagen Type I;cytokine;Cytometry;Development;differential expression;Disease;Duct (organ) structure;Ductal Epithelial Cell;Epithelial Cells;Event;Extracellular Matrix;Fibroblasts;Fibrosis;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Goals;Growth Factor;Human;human subject;Immune;In Vitro;Incidence;Inflammation;Inflammatory;Injury;insight;Investigation;Knock-out;Knockout Mice;KRAS2 gene;Lasers;Lesion;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Metaplasia;Microdissection;migration;Modeling;Molecular;mouse model;Mus;mutant;Natural regeneration;neutrophil;new therapeutic target;novel;Oncogenic;Organ;Outcome;overexpression;Pancreas;pancreas development;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic stellate cell;pancreatic tumorigenesis;Pancreatitis;Pathway interactions;Phase;Phase I Clinical Trials;Phenotype;premalignant;prevent;Process;Production;Proglumide;programs;Protein Array;Proteins;receptor;Receptor Cross-Talk;Recovery;recruit;Research;response;Risk;Role;Safety;Signal Pathway;stellate cell;stem-like cell;Stimulus;Stress;Techniques;Testing;therapeutic target;Tissues;transcriptome sequencing;transdifferentiation;tumor microenvironment;Wild Type Mouse

PROJECT_TITLE: The CCK-B receptor signaling pathway as a driver of pancreatic cellular plasticity and carcinogenesis

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Genetics;Heart Disease;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed study will encompass a comprehensive investigation of the cardiometabolic in utero environment and its association with cardiovascular health (CVH) and arterial injury in young-adult offspring. Findings will give insights into 1) the burden of poor CVH and arterial injury at this critical time of life when cardiovascular disease risk may progress and interventions may slow further progression, 2) timing for future interventional studies in pregnancy and markers to follow to assess effectiveness and 3) novel mechanisms of the passage of cardiometabolic risk from mothers to their children, allowing for potential new targets for intervention.

PI_NAMEs: BRICKMAN, WENDY J (contact);LLOYD-JONES, DONALD M

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: accelerated epigenetic aging;Adult Children;adverse pregnancy outcome;Age;aging related;American Heart Association;Arterial Injury;Behavior;Birth;Blood;Blood Cells;Blood Pressure;Body mass index;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Carotid Arteries;carotid intima-media thickness;Child;Childhood;Clinical;Cohort Studies;Country;critical period;Data;Development;DNA;DNA Methylation;Early identification;effectiveness evaluation;Environment;Epigenetic Process;epigenome;Event;Fasting;follow-up;Follow-Up Studies;Future;Gestational Diabetes;Health;health assessment;Health Status;high risk;Hyperglycemia;Hypertension;in utero;insight;intergenerational;Intergenerational transfer;International;Intervention;Intervention Studies;intimal medial thickening;intrauterine environment;Investigation;Life;Life Cycle Stages;Life Style;Lipids;maternal obesity;maternal outcome;Measures;Mediating;Medical Records;Metabolic;mortality;Mothers;National Heart, Lung, and Blood Institute;neonatal outcome;newborn adiposity;novel;Obesity;obesity in children;offspring;OGTT;Outcome;Outcome Study;Pathway interactions;Phenotype;Postpartum Period;Pregnancy;Pregnant Women;premature;Prevention;primary outcome;prospective;recruit;Resolution;Risk;Role;Site;Standardization;Texture;Time;Ultrasonography;ultrasound;Umbilical Cord Blood;Visit;Woman;Work;young adult

PROJECT_TITLE: Hyperglycemia and Adverse Pregnancy Outcome Study-Cardiovascular Health of HAPO Offspring (HAPO CVH)

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_CITY: Huntington

ORG_DEPT: BIOLOGY

ORG_NAME: MARSHALL UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative: Telomeres shorten with age in most human somatic cells, and while their initial length pre-determines cellular lifespan, the exact nature of factors establishing telomere length set point remains elusive. We will elucidate the genetic and epigenetic architecture of telomere length control and uncover novel pathways modulating natural telomere length polymorphism using the unique biological, genomic and epigenetic resources in the genetically facile plant Arabidopsis thaliana. Because modes of telomere regulation are highly conserved between eukaryotes, our data may provide important insights into the molecular basis for variation in the predisposition to telomere-associated stem cell, cancer and age-related diseases among different individuals.

PI_NAMEs: SHAKIROV, EUGENE V (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Age;age related biomarkers;age-related disease;Aging;Alleles;Arabidopsis;Architecture;ATRX gene;Biochemical;Biogenesis;Biological;Biological Assay;Biology;Candidate Disease Gene;candidate identification;Cell division;Cell Physiology;Cell Proliferation;Cellular biology;Chimeric Proteins;Chromatin Modeling;chromatin modification;chromatin remodeling;Chromosomes;Collection;Complement;Complex;Data;Deposition;Disease;DNA;DNA Methylation;enzyme activity;Epigenetic Process;Eukaryota;Eukaryotic Cell;experimental study;Funding;gene conservation;gene discovery;gene function;gene network;Genes;Genetic;Genetic Polymorphism;Genetic Recombination;Genetic Variation;Genome;genome wide association study;genome wide screen;genome-wide;Genomic approach;Genomics;Genotype;Goals;Histone H3.3;Holoenzymes;Homeostasis;Human;human disease;in vivo;Inbreeding;Individual;inhibitor;innovation;insight;inter-individual variation;Lead;Length;life span;Maintenance;Malignant Neoplasms;Maps;Modeling;Molecular;Mouse-ear Cress;multidisciplinary;mutant;Mutation;Nature;novel;Orthologous Gene;Pathway interactions;Phenotype;Plant Model;Plants;Play;pleiotropism;Population;Predisposition;Premature aging syndrome;Productivity;Proteins;Quantitative Trait Loci;rate of aging;Recombinants;Regulation;Resources;Ribosomes;Role;segregation;Series;Somatic Cell;stem cells;Telomerase;telomere;Telomere Length Maintenance;Telomere Maintenance;Telomere Maintenance Gene;Telomere Shortening;TERT gene;tool;transcriptomics;Transgenic Organisms;tumorigenesis;Variant;Yeasts

PROJECT_TITLE: Genetic and epigenetic architecture of natural telomere length variation

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: The proper regulation of gene expression is essential for the development and health of all organisms. Our work advances the study of how DNA, found as chromatin, plays an integral part in gene regulation (transcription initiation and gene splicing. This knowledge will help guide the development of diagnostic and therapeutic tools, e.g., built upon knowledge of alternative splicing.

PI_NAMEs: FONDUFE-MITTENDORF, YVONNE NSOKIKA (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3-Dimensional;Affect;Alternative Splicing;Animal Model;Arsenic;arsenic carcinogenesis;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biochemical;Biology;Cancer Biology;carcinogenesis;carcinogenicity;Carcinogens;CCCTC-binding factor;Cell model;Cells;Cessation of life;ChIP-seq;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Development;Diagnosis;diagnostic development;Disease;disorder prevention;DNA;DNA Binding;DNA Damage;DNA Methylation;DNA Modification Methylases;Enhancers;Environment;Environmental Exposure;Environmental Pollutants;Epigenetic Process;epigenome;epigenomics;epithelial to mesenchymal transition;Etiology;Exposure to;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genome;genome-wide analysis;Genomic Segment;Genomics;Goals;Growth;Health;Histones;Human;Hybrids;in vivo;Knowledge;Light;Malignant Neoplasms;Maps;Mediating;Metals;metaplastic cell transformation;Modeling;Molecular;Mutation;Neoplasm Metastasis;Nucleosomes;Oncogenic;Organism;Pathogenesis;Pathogenicity;Pathology;Pattern;Persons;Pharmaceutical Preparations;Play;pollutant;Positioning Attribute;prevent;Process;promoter;Proteins;Reactive Oxygen Species;Risk;Role;Site;Spliced Genes;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic development;three dimensional structure;tool;Transcription Initiation;Variant;Work;Writing

PROJECT_TITLE: Molecular Underpinnings in the Establishment of an Oncogenic 3D Genome inResponse to Environmental Arsenic Exposure

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Species are diverse, and the genetic basis of this diversity and how it is encoded in the genome is important to understanding many aspects of biology. The investigation will identify and characterize genes that cause yeast species to survive and grow at different temperatures. Doing so will provide general insight into complex adaptive differences between species and specific insight into the evolution of thermotolerance, a characteristic relevant to many human pathogens.

PI_NAMEs: FAY, JUSTIN C (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Biology;Characteristics;chromosome loss;Chromosome Mapping;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Dependence;Evolution;fitness;Genes;Genetic;genetic analysis;Genome;genome-wide;Goals;Growth;High temperature of physical object;human pathogen;Hybrids;Individual;insight;Investigation;Learning;Maps;Measures;melting;Microbe;Mitotic Recombination;Organism;Phenotype;Polygenic Traits;Proteins;Proteomics;reproductive;Research;Role;Saccharomyces;Saccharomyces cerevisiae;species difference;Sterility;Temperature;Testing;Time;Transgenic Organisms;Variant;Work;Yeasts

PROJECT_TITLE: Genetic basis and evolution of thermotolerance in the Saccharomyces yeast species


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Osteoarthritis;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Our recent cross-sectional findings suggest that chronic pain is associated with multiple biological aging biomarkers where a greater pain burden is associated with accelerated aging processes. Thus, the goal of the proposed study is to determine the brain and bodily aging mechanisms whereby pain prospectively impacts function in aging and whether these are different across racial/ethnic groups. Findings will contribute towards increased understanding of pain and biological aging processes, with the potential to reduce race/ethnic group disparities and improve pain-related health outcomes.

PI_NAMEs: CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;age related biomarkers;age related changes;Aging;aging biomarker;aging brain;aging mechanism;aging process;Behavioral;biobehavior;biogerontology;Biological;biological age;Biological Aging;biological heterogeneity;Biological Markers;Biological Process;biopsychosocial;Black Populations;Blood;Blood Cells;Brain;candidate marker;cell age;Cell Aging;Cells;Characteristics;chronic pain;Chronology;Clinical;clinical pain;clinically relevant;Cognitive;cognitive function;comparison control;Complex;Degenerative polyarthritis;Development;disability;Disease;disorder risk;Disparity population;DNA Methylation;Epigenetic age;epigenetic clock;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Florida;follow-up;functional decline;functional disability;functional outcomes;Future;Goals;Health;Heterogeneity;improved;in vivo;Individual;inter-individual variation;Intervention;Knee Osteoarthritis;knee pain;Knowledge;Length;Leukocytes;life span;loss of function;Measures;Methods;middle age;Modeling;Morbidity - disease rate;mortality;mosaic;neuroimaging;non-opioid analgesic;Not Hispanic or Latino;novel;older adult;Older Population;osteoarthritis pain;Outcome;Pain;Pain Free;pain inhibition;Pain intensity;Pain Measurement;pain relief;pain sensitivity;Pattern;Performance;Personality Traits;personalized predictions;Persons;Phase II Clinical Trials;Physical Function;Physiological;Population Group;predictive marker;predictive modeling;prospective;psychologic;psychosocial;racial difference;racial disparity;racial population;Reporting;Research;Residual state;Risk;social;System;telomere;Therapeutic;Time;Tissues;trait;Underrepresented Minority;Universities;Validation;Visit;Work

PROJECT_TITLE: Biobehavioral basis of knee osteoarthritis pain


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Adolescents may experience manic symptoms that may or may not progress into bipolar disorder. This proposed longitudinal study would be the first of its kind and could shed light on the neural and behavioral markers of disease progression in high-risk adolescents with manic symptoms. Identifying such markers for bipolar disorder has important clinical implications such as improving early detection of illness and informing treatment planning and personalized interventions.

PI_NAMEs: BERTOCCI, MICHELE A;DILER, RASIM SOMER (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Affect;Affective;Age;Age of Onset;aged;Amygdaloid structure;Anterior;Behavior;Behavior assessment;behavior measurement;Behavioral;Biological;Biological Markers;biomarker identification;Biosensor;Bipolar Disorder;Brain;brain behavior;Categories;Childhood;childhood bipolar disorder;cingulate cortex;Clinical;Clinical assessments;clinical predictors;Cognition;Cognitive;cognitive testing;comorbidity;computerized;Corpus striatum structure;cost;Development;Diagnosis;digital;Dimensions;Disease;Disease Marker;Disease Progression;Early Diagnosis;Emotions;Evaluation;experience;follow-up;Functional impairment;Future;Gender;gray matter;high risk;high risk population;high-risk adolescents;Hospitals;hypomania;imaging modality;Impairment;improved;Individual;Inpatients;Intervention;Length;Linear Models;Longitudinal Studies;Machine Learning;machine learning classifier;machine learning model;Magnetic Resonance Imaging;Manic;Matched Group;Measures;mobile application;Modeling;Mood Disorders;mood symptom;Moods;Morbidity - disease rate;Multimodal Imaging;multimodality;neural;neural network;Neurocognitive;neuroimaging;Neurophysiology - biologic function;neuropsychiatry;novel;Onset of illness;Outcome;outcome prediction;Outpatients;Parietal;Patient Self-Report;Pattern Recognition;personalized intervention;Physical activity;Polysomnography;Population;predictive marker;predictive modeling;Prefrontal Cortex;Proxy;Puberty;recruit;Resources;response;Rest;reward processing;Rewards;Risk;Sampling;Severities;Sleep;Specific qualifier value;Stimulus;Structure;Suicide;Symptoms;Syndrome;Testing;Thick;Time;Training;treatment planning;two-dimensional;Uncertainty;Validation;Variant;Ventral Striatum;white matter;Work;young adult;Youth

PROJECT_TITLE: From Manic Symptoms to Bipolar Disorder: Neural-behavioral Markers Using Two Analytic Models

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The best predictor of whether an obese adolescent will develop type 2 diabetes is Insulin Resistance, however its pathogenesis remains elusive. Our previous studies clearly established the link between the impaired accumulation of fat in abdominal subcutaneous depot, fatty liver and peripheral insulin resistance in obese adolescents and, we found a greater release of fatty acids from the subcutaneous depots which is strongly linked with fatty liver. Herein, we will focus on determining what might cause the lack of insulin to suppress the release of free fatty acids, causing a perfect storm of insulin resistance to develop in obese adolescents.

PI_NAMEs: CAPRIO, SONIA  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Abdomen;abdominal fat;Acetyl Coenzyme A;Acute;ADD-1 protein;Adipocytes;Adipose tissue;Adolescence;Adolescent Development;Adolescent obesity;Age;Basic Science;Body fat;Body mass index;Childhood;Clinical Sciences;Closure by clamp;cohort;Complement;Coupled;Development;Endocrinology;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Female Adolescents;follow-up;Funding;Gender;Gluconeogenesis;Glucose;Glucose Clamp;Goals;Grant;Hepatic;hepatic gluconeogenesis;high risk;Hyperinsulinism;Impairment;in vivo;Insulin;Insulin Receptor;Insulin Resistance;Isotopes;Label;Link;Lipase;lipid biosynthesis;Lipids;Lipolysis;Liver;liver development;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Metabolic;Metabolic Marker;metabolic phenotype;Metabolism;Methodology;Methods;Molecular;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nutrient;Nutritional Science;Obesity;obesity in children;OGTT;Pathogenesis;Pathway interactions;Pattern;PDE 3B;perilipin;Peripheral;Phenotype;Phosphorylation;Phosphotransferases;Plasma;Proliferating;Pyruvate Carboxylase;recruit;Research;Rodent;Role;Scientist;sex;stable isotope;sterol esterase;subcutaneous;Techniques;Testing;Thinness;Time;Triglycerides;Youth

PROJECT_TITLE: Metabolic Markers and Predictors of Childhood Obesity

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Fibrotic liver diseases induced by chronic viral infection and metabolic disorders cause significant death annually, yet we lack even one approved anti-fibrotic therapy. We propose to utilize an innovative platform to explore fundamental aspects of human fibrosis formation and regression, and understand the genetic and lifestyle-dependent risk factors that contribute to disease development and progression. These studies will provide new insights that could inform development of effective diagnostics and treatments for these life- threatening conditions.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acids;Address;Affect;Animal Model;Anti-viral Agents;antifibrotic treatment;base;burden of illness;cell immortalization;Cell Line;cell type;Cells;Cessation of life;Chronic;chronic liver disease;Chronic viral hepatitis;Cirrhosis;Clinic;Clinical;clinical phenotype;clinically relevant;Coculture Techniques;connective tissue growth factor;Consensus;cytokine;Cytokine Gene;design;Developed Countries;Development;Diagnostic;Disease;Disease Progression;Dissection;Drug Targeting;effective therapy;Elements;Epigenetic Process;Exhibits;exposed human population;Extracellular Matrix;fibrogenesis;Fibrosis;Functional disorder;Genes;Genetic;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Glucose;Goals;Health;Hepatic Stellate Cell;Hepatitis B;Hepatitis C;Hepatitis C virus;Hepatocyte;Human;human pluripotent stem cell;human stem cell-derived;improved;In Vitro;Individual;Inflammatory;Inflammatory Response;innovation;insight;Insulin;Insulin Resistance;Intervention;Kinetics;Knowledge;Life;Life Style;Link;Lipids;Liver;Liver diseases;Liver Fibrosis;Macrophage;Measurable;Mediating;Metabolic Diseases;Modeling;Molecular;Myofibroblast;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;novel diagnostics;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Phenotype;Physiology;Population;Predisposition;prevent;Process;profibrotic cytokine;Public Health;Regimen;Research;Risk Factors;Role;Signal Transduction;stellate cell;Stimulus;Stress;Supporting Cell;System;Testing;therapeutic development;transcriptome;transdifferentiation;Transforming Growth Factor beta;Variant;Viral;Viral hepatitis;virtual;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: A renewable and genetically tractable human stem cell-derived multicellular platform for the study of fibrotic liver diseases

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Nutrition;Obesity;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The prevalence of severe obesity continues to rise and is strongly linked to many forms of cardiovascular disease; unfortunately, cardiovascular imaging is challenging in these patients as their large size limits accessibility to some imaging modalities, and leads to poor image quality in others, reducing diagnostic accuracy. The use of cardiac magnetic resonance imaging (MRI) is currently limited by the narrow bore and table weight limits of standard MRI machines operating at 1.5T and 3.0T. In this project, we will develop cardiac MRI techniques for a new, low-field, 0.55T MRI machine with an ultra-wide 80 cm patient bore and 700 lb. table weight limit to provide a robust diagnostic cardiovascular imaging option for severely obese patients.

PI_NAMEs: SIMONETTI, ORLANDO PAUL (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: absorption;accurate diagnosis;Address;Adipose tissue;Adult;Affect;American Heart Association;attenuation;black women;Body mass index;Breathing;cardiac magnetic resonance imaging;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular imaging;Cardiovascular system;Caring;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;clinical care;Clinical Management;Compensation;data acquisition;denoising;design;Development;Diagnostic;diagnostic accuracy;Diagnostic Imaging;diagnostic value;Diameter;Dyslipidemias;Echocardiography;efficacy evaluation;Epidemic;Equipment;experience;Face;flexibility;Functional impairment;Goals;head-to-head comparison;Healthcare;healthy volunteer;Heart Diseases;Heart failure;Hispanic;Hypertension;Image;Image Enhancement;image reconstruction;imaging modality;imaging system;implantable device;Incidence;Individual;innovation;Institution;interest;lifetime risk;Link;Machine Learning;magnetic field;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;men;Methods;Modality;Morbid Obesity;Morphologic artifacts;mortality risk;Myocardial tissue;Non-Insulin-Dependent Diabetes Mellitus;non-invasive imaging;novel;obese patients;Obesity;Obesity Epidemic;Outcome;Patients;Physiologic pulse;Physiological;Population;Prevalence;Prognosis;prognostic value;Protocols documentation;Radiation;Radiation Dose Unit;Radiology Specialty;reconstruction;Reference Standards;Reporting;Reproducibility;Risk;Risk Factors;Safety;Scanning;Severities;Signal Transduction;single photon emission computed tomography;statistics;Stroke;Structure;Symptoms;System;Techniques;Testing;tool;ultrasound;Validation;Walking;Weight;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development and validation of cardiovascular MRI techniques on a low-field, ultra-wide bore system to assess patients with severe obesity

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Disability Research;Health Services;Intellectual and Developmental Disabilities (IDD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Infants experience acute physiologic and hormonal responses to pain leading to increased neurologic complications and death, effects which are mitigated by opioid-derived medication. However, opioid use during infancy is also associated with impaired brain development and prolonged hospitalization. In this research, our goals are to identify how variations in pain management strategies impact neurocognitive development and healthcare utilization for critically ill hospitalized infants.

PI_NAMEs: KELLEY-QUON, LORRAINE I (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acute;Address;Admission activity;Birth Weight;Brain Death;Brain Injuries;California;cardiovascular risk factor;Caring;Cessation of life;Child;Childhood;Clinical;Clinical Data;Clinical Protocols;Cognitive;cohort;comorbidity;congenital heart abnormality;cost;Cost Analysis;cost comparison;Critical Illness;Data;Data Set;Databases;Dedications;Dependence;Development;Developmental Disabilities;disability;Dose;early childhood;experience;Exposure to;Extracorporeal Membrane Oxygenation;Fentanyl;Goals;Health;health care service utilization;health difference;Health Information System;Health Policy;Helping to End Addiction Long-term;high risk infant;Hormonal;Hospitalization;Hospitals;Hydromorphone;impaired brain development;improved;infancy;Infant;Institution;instrument;Intervention;Language;Length of Stay;Link;longitudinal dataset;Longterm Follow-up;Methadone;Morbidity - disease rate;Morphine;morphine equivalent;Motor disability;Necrotizing Enterocolitis;Neonatal;Neonatal Abstinence Syndrome;neonatal care;Neurocognitive;neurodevelopment;Neurodevelopmental Disability;Neurologic;novel;Operative Surgical Procedures;Opioid;opioid abuse;opioid exposure;opioid use;Outcome;Pain;Pain management;Parenteral Nutrition;Pediatric Hospitals;Perinatal;Pharmaceutical Preparations;Pharmacy facility;Physiological;Policy Maker;Population;Population Heterogeneity;Pregnancy;prenatal;prescription opioid;prevent;Procedures;programs;Public Health;Quality of Care;Regression Analysis;Research;Resources;response;Risk;Shapes;Survivors;Time;United States;United States National Institutes of Health;Variant;Ventilator;Weight

PROJECT_TITLE: The Impact of Opioids on Health Outcomes for Hospitalized Infants

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Narrative Taking advantage of technologies in functional genomics, studies are proposed in this application to resolve molecular interactions between environmental carcinogens and LINE-1 (Long Interspersed Element-1) retrotransposons in lung epithelial cells. LINE-1 is polymorphic in human populations and these variations may account for differences in susceptibility to changes in oncogenic signaling, chromatin structure and malignant transformation caused by LINE-1.

PI_NAMEs: RAMOS, KENNETH S. (contact)

PROJECT_TERMS: Aromatic Polycyclic Hydrocarbons;Automobile Driving;Benzo(a)pyrene;Binding;Biological;Biological Assay;Biological Markers;Cancer cell line;cancer type;Cancerous;carcinogenicity;Carcinogens;Cell Line;Cell Respiration;Cells;Chromatin Structure;Cities;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;constitutive expression;CRISPR screen;design;Development;Disease;Disparity;DNA;DNA Adducts;DNA Damage;DNA Methylation;DNA sequencing;Elements;Environment;Environmental Carcinogens;Environmental Pollution;Epigenetic Process;Epithelial Cells;Event;exposed human population;Exposure to;Family;Female;functional genomics;gene environment interaction;Genes;Genetic;genetic manipulation;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Recombination;Genetic study;Genome;genome-wide;Genomic Instability;Heterogeneity;Human;Human Genome;Hydrocarbons;in silico;In Vitro;in vivo;inducible gene expression;insight;Instruction;Investigation;Knowledge;KRAS2 gene;Laboratories;Length;Life Cycle Stages;Light;Link;Liver;Location;Long Interspersed Elements;Lung;male;Malignant - descriptor;Malignant neoplasm of lung;Mediating;Mediator;member;mouse model;Mus;Mutate;Non-Small-Cell Lung Carcinoma;novel therapeutics;Oncogenic;Outcome;Parents;Pathogenicity;Population;Predisposition;Process;promoter;Protocols documentation;renal epithelium;Respiratory Disease;respiratory health;response;Retroelements;Retrotransposition;Retrotransposon;Role;Signal Transduction;single-cell RNA sequencing;Technology;Testing;Toxic effect;TP53 gene;transcriptomics;tumor;Validation;Variant

PROJECT_TITLE: Functional Genomics of LINE-1 Retrotransposition


NIH_SPENDING_CATS: American Indian or Alaska Native;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Wound Healing and Care

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE At Stanford over the last decade, the Gurtner group has used NIDDK funding to identify the best treatment plans to improve blood flow, decrease blood glucose, and enhance the body's ability to heal wounds and prevent amputations. With Dr. Gurtner recently assuming the position of Chair of Surgery at the University of Arizona (UArizona) College of Medicine-Tucson, the entire team has moved and worked tirelessly to seamlessly transfer all the existing Diabetic Foot Consortium (DFC) studies to UArizona. In this proposal, we will continue these important studies at UArizona to collect a large range of samples from a diverse patient population to improve biomarker identification and standard of care efforts for DFUs, as well as demonstrate our potential for the addition of various satellite sites throughout the Southwest.

PI_NAMEs: GURTNER, GEOFFREY C (contact);ZHOU, WEI

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: academic program;Acceleration;Address;Adherence;Adult;Affect;American;American Indian Population;American Indians;Amputation;Ancillary Study;Arizona;bench to bedside;Bioinformatics;Biological Markers;biomarker identification;biomarker validation;Blood flow;Blood Glucose;Blood Vessels;Caring;Cells;Chairperson;chronic wound;Clinical;clinical care;clinical center;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Collection;college;Communities;Community Actions;comorbidity;Complex;contextual factors;Data;Debridement;Dedications;demographics;design;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;drug candidate;Education;Educational Status;Environment;Ethnic Origin;experience;FDA approved;Foundations;Funding;Grant;healing;Health;Heterogeneity;higher education;Hispanic;Hispanic Populations;Human;improved;Individual;Infrastructure;innovation;Institution;interdisciplinary approach;International;Intervention;Latino;limb amputation;Limb Salvage;Lower Extremity;Medical;Medicine;Minority;Mission;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;open wound;Operative Surgical Procedures;outcome prediction;outreach;outreach program;Pathologic;Pathology;Patient Care;Patient Compliance;patient population;Patient Recruitments;Patients;Persons;Physicians;Podiatry;Population;Positioning Attribute;predictive marker;Prevalence;prevent;Problem Solving;programs;provider adherence;Publications;Recommendation;Recording of previous events;recruit;Recurrence;Reporting;Research;Resource Sharing;Role;Sampling;Services;single-cell RNA sequencing;Site;social;social deprivation;social factors;social health determinants;Socioeconomic Status;Source;standard of care;Surgeon;Techniques;Testing;Tissues;Trauma;treatment planning;United States;United States Indian Health Service;United States National Institutes of Health;Universities;Work;wound;wound care;wound healing

PROJECT_TITLE: The University of Arizona Wound Care Center Clinical Research Unit


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Prevention

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because the discovery that delta cell-dependent feedback loss over glucagon and insulin release from pancreatic islets causally contributes to diabetes suggest that the targeting of local feedback may prove to be a novel way to treat patients across the diabetes spectrum. Thus the proposed research is relevant to NIDDK's mission because it directly addresses a critical unmet need to improve the health and quality of life of the millions of Americans with diabetes.

PI_NAMEs: HUISING, MARK O. (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Adult;Agonist;Alpha Cell;American;Ants;Attenuated;Behavior;Beta Cell;Biosensor;blood glucose regulation;Calcium;CDC42 gene;cell behavior;Cell surface;Cells;Cilia;Cyclic AMP;Cytoskeleton;D Cells;diabetes management;Diabetes Mellitus;Disease;Dyes;Epidemic;Equilibrium;Exocytosis;Exocytosis Inhibition;experimental study;F-Actin;Feedback;Fluorescence Resonance Energy Transfer;Gap Junctions;Genetic Transcription;Glucagon;Glucose;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Hormones;Hyperglycemia;Hypoglycemia;improved;Individual;Injections;innovation;Insulin;Insulin deficiency;insulin secretion;islet;Islet Cell;Islets of Langerhans;Learning;Literature;Liver;Measures;Mediating;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;new therapeutic target;novel;novel strategies;Nutrient;Pancreatic delta Cell;paracrine;Pathway interactions;Patients;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Physiological;Physiology;Positioning Attribute;Prediabetes syndrome;prevent;Public Health;Publishing;Quality of life;Research;response;restraint;Role;Somatostatin;Somatostatin Receptor;Source;SSTR2 gene;SSTR3 gene;standard care;Structure of beta Cell of islet;Testing;Therapeutic;Time;Tolbutamide;Translating;type I and type II diabetes

PROJECT_TITLE: Paracrine feedback by pancreatic delta cells to control glucagon and insulin release and manage diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Expanding access to medications for opioid use disorder, including buprenorphine for opioid use disorder treatment and naloxone for overdose reversal, is a critical piece in a comprehensive plan for addressing the opioid epidemic. The proposed research will contribute knowledge about existing barriers to integrating evidence-based opioid use disorder treatment in the hospital setting and aims to expand access to buprenorphine and naloxone for hospitalized patients with opioid use disorder. The proposal closely aligns with NIDA’s strategic goal to “to help people with addiction achieve a meaningful recovery”.

PI_NAMEs: CALCATERRA, SUSAN L (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;addiction treatment referral;Address;Adoption;Belief;Buprenorphine;career;career development;Caring;Communities;comparative effectiveness trial;Consult;cost;Country;County;Data;Development;Development Plans;Disease Management;dissemination science;Effectiveness;Electronic Health Record;Ensure;evidence base;Evidence based practice;Evidence based treatment;experience;Focus Groups;Future;Goals;Health Personnel;Health Services;high risk;Hospitalists;Hospitalization;Hospitals;implementation barriers;implementation intervention;implementation science;Improve Access;improved;Incentives;innovation;Inpatients;Intervention;intervention refinement;Interview;Investigation;Knowledge;Leadership;Learning;Licensing;Life;Link;Literature;Measures;Medical;medical specialties;medication for opioid use disorder;meetings;Mentors;Mentorship;Methods;Modeling;multi-component intervention;Naloxone;naloxone dispensing;National Institute of Drug Abuse;novel strategies;Nurses;opioid epidemic;opioid use;opioid use disorder;Overdose;Overdose reversal;Patient Care;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;pilot test;Positioning Attribute;post intervention;Privatization;Process;Protocols documentation;Provider;provider behavior;Psychiatrist;Publications;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;safety net;Screening procedure;Services;skill acquisition;skills;Social Workers;Specialist;State Hospitals;Structure;Suboxone;substance use;Surveys;Testing;therapy development;Training;United States;Universities;waiver

PROJECT_TITLE: Understanding Factors that Limit Access to Opioid Use Disorder Treatment in the Hospital to Inform Innovative Approaches to Expand Hospital-Based Treatment

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Childhood Injury;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine

ORG_CITY: GOLDEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO SCHOOL OF MINES

PHR: NARRATIVE The growth plate (or physis) is a cartilage region at the end of all long bones in children that provides signals for bones to lengthen during development; when injured, bony tissue can form in the growth plate, resulting in a “bony bar” that can cause deformities or even completely halt bone growth. This project aims to investigate the development of biomaterial systems that are capable of blocking the angiogenic processes that contribute to the formation of the bony bar. The impact of the extracellular matrix environment on this process will be investigated through the modification of the biomaterial delivery systems with anti-angiogenic peptides and extracellular matrix molecules.

PI_NAMEs: KREBS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Affect;Alginates;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Angiogenic Peptides;Animal Model;Antibodies;Area;Biocompatible Materials;biomaterial development;bone;Bone Growth;Cartilage;cartilaginous;cell behavior;Child;Childhood;Chitosan;Chondrogenesis;Clinic;Clinical;cost;Cues;Deformity;Development;Endothelial Cells;Environment;Epiphysial cartilage;Extracellular Matrix;Fracture;Goals;Growth;healing;Histologic;Hyaluronic Acid;Hydrogels;Impairment;In Vitro;in vivo;Injectable;injured;Injury;innovation;Lifelong disability;Link;long bone;microCT;Modeling;Modification;Molecular Weight;novel;Operative Surgical Procedures;Osteogenesis;Pathway interactions;pediatric patients;Peptides;Physiological;Play;prevent;Prevention;Process;protein aminoacid sequence;Rattus;regenerative;regenerative therapy;repaired;Research;response;Role;Signal Pathway;Signal Transduction;Site;Skeleton;System;Technology;tissue repair;Tissues;transcriptome sequencing;Translating;Translations;treatment strategy;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Extracellular Matrix Impacts Angiogenesis and Growth Plate Repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Project Narrative CHCs provide a unique setting for examining the delivery of integrated services in a primary care setting, yet there is a paucity of information on the impact of service-specific payment policies on the service delivery and activities. To fill this gap, we initiate new research, using a sample of 3,868 health center-year observations with complete policy information and other covariates.

PI_NAMEs: DOR, AVI  (contact)

PROGRAM_OFFICER_NAME: HELLINGER, FRED

PROJECT_TITLE: Impact of Payment Methods on Service Delivery at Community Health Centers

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Back pain is frequently associated with degeneration of the intervertebral discs of the spine and places a significant social and economic burden on active duty military, veterans and the general public. Current treatments for disc degeneration, such as spinal fusion, are limited in that they do not restore healthy disc structure or function. The objective of this proposal is to further advance our tissue engineered intervertebral disc replacement technology towards clinical use. This will be achieved via long term studies in a large animal model under clinically relevant conditions, and by in vitro studies utilizing translatable human cell sources for engineered disc fabrication and culture. Overall, the results from this work will drive clinical translation of our tissue engineered disc technology, significantly improving treatment options for veterans suffering from disc degeneration and back pain.

PI_NAMEs: MAUCK, ROBERT L;SMITH, HARVEY E. (contact)

PROJECT_TERMS: 3D Print;active duty;analog;Anatomy;Animal Model;Animals;Articular Range of Motion;Back Pain;Binding;Bone Marrow;bone marrow mesenchymal stem cell;Cell Survival;cell type;Cells;Cervical;Cervical spine;Chondroitin ABC Lyase;chronic pain;Clinical;clinical translation;Clinical Treatment;clinically relevant;Custom;Data;design;Development;Economic Burden;Electromyography;Electroplating;Elements;Engineering;Ensure;Environment;Euthanasia;Evaluation;fabrication;Facet joint structure;first-in-human;Funding;Gene Expression Profile;General Population;Goals;Goat;Human;human induced pluripotent stem cells;Hydrogels;Immobilization;Implant;implantation;improved;In Vitro;in vivo;Incidence;Inferior;Injections;Intervertebral disc structure;Intervertebral Disk Chemolysis;intervertebral disk degeneration;kinematics;Length;Location;Longitudinal Studies;Low Back Pain;Magnetic Resonance Imaging;mechanical properties;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Military Personnel;minimally invasive;Modeling;Motion;multimodality;Muscle;nanofiber;neural;nucleus pulposus;Operative Surgical Procedures;Pain Measurement;Pathology;Patients;Performance;Physiological;Polymers;preservation;Property;regenerative therapy;restoration;sample fixation;screening;service member;social;Source;Spinal;Spinal Fusion;spine bone structure;stem cells;Structure;subcutaneous;System;Technology;Testing;Therapeutic;Time;Tissue Engineering;Tissues;Translating;translational goal;Translations;Vertebral column;Veterans;Work

PROJECT_TITLE: Tissue Engineered Total Disc Replacement in a Large Animal Model

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Infection with influenza virus poses a major global public health concern, as it causes significant morbidity and mortality during annual epidemics and has instigated pandemics by strains to which the human population is naive. Currently licensed influenza vaccines induce suboptimal strain-specific immune responses, requiring yearly reformulation and administration due to antigenic drift and short duration of protection. In this proposal we compare vaccination strategies using a rationally designed mucosal combination adjuvant, consisting of a nano emulsion and synthetic RNA, with established adjuvants to identify if a multi-season as well as a universal influenza vaccine candidate can benefit from the synergistic effects of simultaneous activation of innate immune pathways as measured by improved vaccine efficacy, duration, and breadth in the context of pre-existing immunity.

PI_NAMEs: SCHOTSAERT, MICHAEL  (contact);WONG, PAMELA TINMOI

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: acquired immunity;adaptive immune response;adaptive immunity;Adjuvant;Agonist;Antibodies;Antigens;Automobile Driving;Avian Influenza A Virus;Birds;Cellular Immunity;Clinical;cross immunity;design;Development;Development Plans;Dose;Epidemic;Epitopes;experimental study;exposure route;Formulation;Goals;Head;Hemagglutinin;Human;Immune;Immune response;Immunity;Immunization;immunogenic;improved;Infection;Influenza;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza virus strain;influenza virus vaccine;influenzavirus;innate immune pathways;Innate Immune Response;Intramuscular;Licensing;Lung;Measures;Memory;Memory B-Lymphocyte;MF59;Modeling;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;nanoemulsion;National Institute of Allergy and Infectious Disease;Natural Immunity;Neuraminidase;Outcome;pandemic disease;parenteral administration;Pathogenicity;Pathway interactions;Peripheral;Population;pre-clinical;Proteins;Public Health;rational design;receptor;Recombinants;Regimen;research clinical testing;respiratory;response;RNA;Route;seasonal influenza;Seasons;Sendai virus;sex;Shapes;Strategic Planning;Structure of germinal center of lymph node;System;T cell response;T-Lymphocyte;Testing;universal influenza vaccine;Vaccinated;Vaccination;vaccination strategy;vaccine candidate;vaccine efficacy;vaccine response;vaccine-induced immunity;Vaccines;Viral;Viral Antigens;Viral Hemagglutinins;Virus;Virus Activation

PROJECT_TITLE: Adjuvant strategies for universal and multiseasonal influenza vaccine candidates in the context of pre-existing immunity

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE STATION

PHR: PROJECT NARRATIVE Vancomycin is the most important drug for C. difficile infection (CDI). This study investigates vancomycin resistance mechanisms in C. difficile and their clinical impact, as well was researches alternate treatments.

PI_NAMEs: GAREY, KEVIN W;HURDLE, JULIAN G (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Affect;Antibiotic Resistance;Antibiotics;Autolysis;Back;Binding;biobank;Biochemistry;Bioinformatics;Biological;Biology;Bioreactors;Cell Wall;Cessation of life;Characteristics;Clinical;Clinical Data;clinical efficacy;clinical practice;Clinical Research;Clostridium difficile;Collection;Colon;cost;Data;Decision Making;Diagnosis;Diagnostic;disabled;Disease;Disease Outbreaks;Dose;Drug resistance;Economic Burden;emerging pathogen;Epidemic;Epidemiology;epidemiology study;Evolution;Failure;FDA approved;fluoroquinolone resistance;Fluoroquinolones;Foundations;Genetic;Genetic Programming;genetic signature;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome wide association study;Genomics;Glycopeptides;Goals;Hamsters;high risk;Hospitals;Impairment;improved;In Vitro;Infection;infection risk;International;Investigation;Lipid Binding;Lipids;Metadata;Metronidazole;Metronidazole resistance;Microbial Genetics;microbiome;microbiota;minimal risk;Modeling;Molecular;molecular diagnostics;Molecular Epidemiology;Molecular Genetics;Morbidity - disease rate;mortality;Mus;mutant;Mutate;Nitroreductases;Operon;Organism;Osmoregulation;Outcome;Outcomes Research;Pathologic;Patient Isolation;Patient-Focused Outcomes;Patients;Pattern;Periodicity;Pharmaceutical Preparations;pharmacologic;phenotypic data;phosphoric diester hydrolase;Physiological;population based;Population Genetics;preclinical study;Predisposition;pressure;Prevalence;Public Health;rapid detection;Recurrence;Reporting;Research;Resistance;Resistance development;resistance mechanism;resistant strain;response;Risk;Sampling;Science;Selection for Treatments;Severity of illness;Systems Biology;telavancin;Testing;Therapeutic;trait;transmission process;Treatment Failure;treatment response;United States;Validation;Vancomycin;Vancomycin Resistance

PROJECT_TITLE: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection.

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE Staphylococcus aureus persistently colonizes humans which represents the key risk factor for community- and hospital-acquired infections with poor clinical outcomes. We propose that upper respiratory tract clearance of S. aureus is key to curbing invasive disease and will capitalize our investigations by exploiting a mouse model of colonization, and prototype vaccines that neutralize the immune evasion attributes of Staphylococcal protein A and block factors of colonization. We expect to gain insights into B cell responses in mucosal-associated lymphoid tissues and decipher the mechanisms whereby serum and luminal antibodies may promote colonization clearance.

PI_NAMEs: MISSIAKAS, DOMINIQUE M. (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Adhesions;Animal Model;Animals;Antibiotic Resistance;Antibodies;Antibody Binding Sites;Antibody Response;antigen binding;Antigens;B Cell Proliferation;B cell repertoire;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Bacteria;Binding;Binding Sites;Biochemical;blocking factor;Blood Circulation;Cell surface;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Communicable Diseases;Communities;community-level factor;Complement 1q;Complement Activation;crosslink;Development;Diffusion;Disease;Disease Outcome;Engineering;Environment;Enzymes;Exposure to;FDA approved;Genes;Genetic;Genetically Modified Animals;Genus staphylococcus;Goals;Gram-Positive Bacteria;Hospitals;host colonization;Human;Immune;Immune Evasion;Immune response;Immunization;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologics;immunoregulation;in vitro Assay;in vivo;Individual;Infection;Infection Control;insight;Investigation;Lead;Left;Life;Link;Lung;Lymphoid Tissue;Measures;Mediating;Membrane Proteins;Methicillin;methicillin resistant Staphylococcus aureus;microscopic imaging;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mucosa-associated lymphoid tissue;Mus;mutant;Nasal cavity;Nasopharynx;neonatal Fc receptor;neutralizing antibody;neutralizing vaccine;Nose;Nosocomial Infections;Outcome;pathogen;pathogenic bacteria;Patients;Peptidoglycan;Plasma;prevent;programs;Proteins;prototype;Reporting;resistant strain;response;Risk Factors;Scheme;Sepsis;Serum;skeletal;Skin colonization;soft tissue;sortase;Specificity;Staphylococcal Protein A;Staphylococcus aureus;Staphylococcus aureus infection;State Hospitals;Structure of germinal center of lymph node;Surface;Testing;Tissues;transmission process;Treatment Failure;United States;Upper respiratory tract;uptake;vaccine candidate;Vaccines;Variant;wound

PROJECT_TITLE: Vaccine Assembly from Surface Proteins of Staphylococcus aureus

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The continued high rate of suicide among Veterans, variable successes with currently available suicide prevention screening methods and interventions, and limited use of precision medicine methods in prior suicide prevention research suggests that the field is overdue for a precision medicine approach to suicide prevention. This agenda will require suicide prevention researchers to be trained in precision medicine methods and have the resources needed to conduct much more sophisticated studies than in the past. The immediate goal of this proposal is to advance this agenda by establishing a VA Suicide Prevention Clinical Resource Center with an explicit focus on promoting precision medicine for suicide prevention. In so doing, we seek to improve individual suicide prevention outcomes, address unsatisfactory response rates for standardized treatments, promote the incorporation of diverse patient presentations, characteristics, and needs into treatment plans, improve system and population-level outcomes, and increase efficient use of finite resources.

PI_NAMEs: GOODMAN, MARIANNE ;INTERIAN, ALEJANDRO ;KIMBREL, NATHAN A.;MARX, BRIAN  (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Assessment tool;Biological Markers;career;Characteristics;Clinical;Clinical Trials;Collaborations;Communities;community partners;comparative effectiveness study;Consultations;Data;Data Analyses;data repository;Death Rate;Development;Disparity;Education;education resources;Effectiveness;experience;Faculty;Fellowship;Funding;Funding Mechanisms;Goals;Grant Review;Growth;Guidelines;improved;Individual;Infrastructure;innovation;Intervention;Leadership;member;Mentors;Mentorship;Methodology;Methods;Mission;Monitor;next generation;Outcome;Patients;Pilot Projects;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;precision medicine;Predictive Analytics;Prevention Research;preventive intervention;Protocols documentation;Publishing;Qualifying;Recommendation;reducing suicide;Research;research and development;Research Design;research facility;Research Personnel;Resources;response;Review Literature;Risk;Role;Safety;Science;screening;secondary analysis;service member;Services;social determinants;Standardization;success;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide mortality;Suicide prevention;suicide rate;synergism;System;therapy development;Time;timeline;tool;Training;Training and Education;Training Programs;treatment planning;Veterans;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Center for Harmonizing and Improving Interventions to Prevent Suicide (CHIIPS)


ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The Jumonji histone demethylases are enzymes that drive cancer’s uncontrolled growth and allow cancer cells to adapt to therapeutic toxic stress, surviving it. Here we propose to define how a key Jumonji enzyme in lung cancer gets activated when DNA is damaged with radiation therapy and to find ways to block the activity of this enzyme in order to sensitize non-small cell lung cancers to radiation, overcoming radiation resistance. Our goal is to make lung tumors exquisitely responsive to radiation therapy locally, without any damage to normal tissue.

PI_NAMEs: MARTINEZ, ELISABETH D (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Alanine;Aspartic Acid;ataxia telangiectasia mutated protein;cancer cell;Cancer Patient;Cell Death;Cell Line;Cell Survival;Cells;Chromatin;Consensus Sequence;demethylation;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;enzyme activity;enzyme substrate;Enzymes;Epigenetic Process;Exposure to;Foundations;gain of function;Genetic Transcription;Genomics;Glutamic Acid;Goals;Grant;Growth;histone demethylase;Histones;homologous recombination;In Vitro;inhibitor;Ionizing radiation;KDM5B gene;knock-down;Knock-out;Local Therapy;loss of function;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediating;Modernization;Molecular;Mutate;Non-Small-Cell Lung Carcinoma;Nonhomologous DNA End Joining;Normal tissue morphology;novel;novel strategies;Oncogenic;overexpression;palliative;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Radiation;radiation resistance;Radiation therapy;recruit;repaired;Resistance;Resolution;response;Role;Signal Transduction;Site;Stress;Therapeutic;Treatment Protocols;tumor;Tumor Tissue

PROJECT_TITLE: Post-translational modifications control JARID enzyme activity during DNA damage


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE More than one-third of children with epilepsy do not respond to medications and are therefore candidates for epilepsy surgery. Developing a robust tool to identify abnormal brain areas for surgical intervention would be a groundbreaking advancement in treating children with epilepsy. This project aims to investigate promising spatial neurophysiological biomarkers of the epileptic brain known as high-frequency oscillations through a novel deep learning-based approach.

PI_NAMEs: NARIAI, HIROKI  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Algorithms;Area;Behavioral;Biological;Biological Markers;biomarker identification;Brain;brain abnormalities;Brain region;brain tissue;Characteristics;Child;Childhood;childhood epilepsy;Chronic;Clinical;Clinical Research;Clinical Trials;cohort;cortex mapping;Data;deep learning;deep learning algorithm;deep learning model;dexterity;Electroencephalography;Epilepsy;Evaluation;Excision;feasibility testing;Freedom;Frequencies;Goals;Hand;High Frequency Oscillation;Image;Joints;K-Series Research Career Programs;Knowledge;Label;Language;large datasets;Link;Maps;Mentors;Mentorship;Methods;Microelectrodes;Modeling;Morbidity - disease rate;Morphology;mortality;neocortical;Neurons;neurophysiology;neuroregulation;novel;Operative Surgical Procedures;Outcome;Partial Epilepsies;Pathologic;Pharmaceutical Preparations;Physicians;Physiological;Postoperative Period;postsynaptic;predictive modeling;preservation;Property;Prospective cohort;Research;Research Personnel;Resistance;Retrospective cohort;Scientist;secondary analysis;Seizures;signal processing;Signal Transduction;Site;skill acquisition;skills;statistics;Synaptic Potentials;Testing;theories;Time;tool;Training;two-dimensional;Vision;Work

PROJECT_TITLE: Refining neurophysiological biomarkers of epilepsy using deep learning to guide pediatric epilepsy surgery

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Foodborne Illness;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Emerging data indicate that exposure to relatively low levels of contaminants during pregnancy may adversely affect placental and fetal development. This project will extend our rural U.S. pregnancy cohort to investigate the effects of toxicants in our drinking water and diet on placental features and birth size and generate the necessary knowledge to inform policies and clinical practices geared at improving the health and well-being of women and children.

PI_NAMEs: ROMANO, MEGAN E (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acetates;Adult;adverse birth outcomes;Affect;Air;Alkanesulfonates;Area;Biological;Biopsy;Birth;Birth length;Birth Weight;Blood;cardiovascular risk factor;Chemicals;Child;Circulation;Clinical;clinical practice;cohort;Cohort Studies;consumer product;Data;Deterioration;Diameter;Diet;drinking water;Enrollment;Environment;Environmental Pollutants;Epidemiology;epidemiology study;excessive fetal growth;Exposure to;Family;Fetal Development;Fetal health;Food;Food Supply;General Population;Gestational Diabetes;gestational weight gain;Goals;Growth;Guidelines;Head circumference;Health;Health Policy;Human;improved;indexing;Industrialization;Industry;Infant;infant morbidity;infant morbidity/mortality;Ingestion;Kidney;Knowledge;Literature;Liver;Low Birth Weight Infant;Maternal and Child Health;Maternal Health;maternal outcome;Measures;Mediating;Metabolic;Metadata;Methodology;Modeling;Monitor;Morbidity - disease rate;Mothers;New Hampshire;Newborn Infant;novel;Nutrient;Outcome;Oxygen;perfluorohexane;perfluorooctane;perfluorooctane sulfonate;perfluorooctanoic acid;Personal Satisfaction;Placenta;Placental Insufficiency;Placentation;Play;Policies;pollutant;Poly-fluoroalkyl substances;Population;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy hypertension;Pregnant Women;prenatal;prenatal exposure;prevent;Production;prospective;Prospective cohort;public health priorities;Regulation;Research;Risk;Role;Rural;Sample Size;Sentinel;sex;sociodemographics;Source;Specimen;Subgroup;Testing;Time;time-to-pregnancy;Tissues;toxicant;Toxicant exposure;wasting;Water;Water Pollutants;Water Supply;Weight;Woman;Work

PROJECT_TITLE: Effects of per- and polyfluoroalkyl substances on placental features and size at birth

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Strategies that can simultaneously improve the function and health of pancreatic beta cells, which produce all of the insulin needed for the body, may be effective against beta cell dysfunction and demise in diabetes. The studies proposed in this application will characterize metabolic mechanisms that render beta cells resilient to stress caused by inflammation, glucotoxicity and oxidative stress. By revealing how beta cell stress response and adaptation is controlled, these studies can help improve strategies to improve the health of beta cells in diabetes.

PI_NAMEs: DANIAL, NIKA N (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Activities of Daily Living;Address;Anabolism;Antioxidants;Arginine;Beta Cell;Binding;Bioenergetics;biological adaptation to stress;cell growth;Cell Proliferation;Cell Shape;Cell Survival;Cells;Cellular Metabolic Process;Cellular Stress;Citric Acid Cycle;Compensation;Complement;Cytoprotection;Defense Mechanisms;Diabetes Mellitus;Diet;Enzymes;Equilibrium;Functional disorder;functional improvement;functional restoration;Generations;Genetic;Genetic Transcription;Glucokinase;Glucose;glucose metabolism;Glutathione;Grant;Growth;Health;High Fat Diet;Human;improved;In Vitro;in vivo;Inflammation;insight;Insulin;insulin secretion;insulin signaling;islet;Islets of Langerhans Transplantation;Knockout Mice;Maintenance;Mediating;Metabolic;Metabolic Pathway;metabolomics;mimicry;Mitochondria;Modeling;Molecular;mouse model;Mus;Nitric Oxide;nitrosative stress;Obesity;Ornithine;overexpression;Oxidative Stress;Pathway interactions;Pattern;pharmacologic;Phosphorylation;Physiological;Polyamines;preservation;Production;programs;Proliferating;protective effect;Proteins;Pyruvate;Pyruvate Carboxylase;Regulation;response;Role;Route;Signal Pathway;Signal Transduction;stem;Stimulus;Stress;stress resilience;Structure of beta Cell of islet;Testing;transplant model;transplantation therapy;Urea;urea cycle

PROJECT_TITLE: Metabolic crosstalks in regulation of beta-cell stress response and adaptation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Improved prevention and treatment of major psychiatric disorders in youth is a national priority. This R25 targets the critical transition of postdoctoral fellows and junior faculty without research grant funding to successfully funded researcher through a one-week Research Institute and subsequent year-long mentoring process. Our career development approach is based on the model of other successful Summer Research Institutes that target researchers studying adults and geriatric populations but modified to give greater emphasis on grant design and writing and greater time to small-group and one-on-one mentoring with many of the most senior researchers in this field.

PI_NAMEs: RYAN, NEAL D. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Active Learning;adolescent mental health;Adult;Applications Grants;Area;Arizona;Award;Budgets;California;career;career development;career networking;Child;Child Mental Health;Child Psychiatry;Child Psychology;child services;Clinical;cohort;Communities;Community Psychology;Consultations;Country;COVID-19 impact;Data;design;Development;Development Plans;developmental psychology;Disease;Doctor of Philosophy;early-career faculty;Education;Educational process of instructing;Educational workshop;Elderly;Epidemiology;Equilibrium;Ethics;ethnic minority;ethnic minority population;Ethnic Population;Evaluation;Exercise;Faculty;faculty mentor;Family;flexibility;Florida;Funding;Geography;Goals;graduate student;Grant;health disparity;Health Services Research;improved;Individual;interest;Intervention;intervention program;Intervention Studies;Life;life span;Los Angeles;Measures;Medicine;member;Mental disorders;Mental Health Services;Mentors;Methods;Minority Health Research;minority investigator;Modeling;multidisciplinary;National Institute of Mental Health;Natural History;Neurosciences;Oregon;Parents;Participant;pharmacologic;Population;post-doctoral training;Postdoctoral Fellow;Prevention;Prevention program;Prevention Research;Process;Productivity;Program Effectiveness;programs;psychosocial;Publications;racial population;recruit;Request for Applications;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Sampling;Science;Scientist;senior faculty;service programs;Services;Site;skills;social learning;Social Work;Sociology;success;Suicide;summer institute;summer research;System;Telephone;Time;Training;Universities;Virginia;Visit;Washington;Work;Writing;Youth

PROJECT_TITLE: Child Intervention, Prevention and Services Research Mentoring Network


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Project Narrative The Downstate Clinical Research Scholars Training Program (CREST) will increase the number of underrepresented physicians and nurses who are trained to conduct rigorous research and continue as leaders in clinical research careers. By diversifying the clinical workforce, the CREST contributes to addressing the critical need to reduce racial and ethnic health disparities.

PI_NAMEs: BOUTIN-FOSTER, CARLA  (contact);CAMACHO, MARLENE ;LAMBERT, WILLIAM MARCUS

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Academic support;Address;Advisory Committees;anti-racism;Biomedical Research;Biometry;career;career development;catalyst;Clinical;clinical development;clinical practice;Clinical Research;Clinical Trials;Collaborations;college;Color;Communities;community advisory board;community engagement;community partners;community partnership;Competence;Country;Coupled;COVID-19 pandemic;Data;Dedications;didactic education;Discipline of Nursing;Discrimination;Disparity;Doctor's Degree;educational atmosphere;Educational Curriculum;Educational workshop;Eligibility Determination;Endowment;Enrollment;Equity;ethnic health disparity;Event;evidence base;experience;Faculty;Fostering;Funding;Future;Goals;Grant;Growth;Health;Health Disparities Research;health disparity;health equity;Health equity research;Health system;Healthcare;Hospitals;Hybrids;Incubators;Individual;Infrastructure;innovation;Institution;Intervention;Intervention Trial;Leadership;Master of Public Health;Medicine;Mentors;Mentorship;Modality;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;New York;New York City;Nurses;Outcome;Patients;Personal Growth;Persons;Physicians;Pilot Projects;Policies;Positioning Attribute;Preparation;programs;Public Health;Public Health Schools;racial health disparity;racism;Recording of previous events;recruit;Reduce health disparities;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;response;Science;Scientist;skills;social;Structural Racism;Structure;Students;Time;Training;Training Programs;Trauma;Underrepresented Populations;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Clinical Research Scholars Training (CREST) Program