ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Public Health Relevance Anopheles stephensi invasion into the African continent has brought serious new challenges for malaria control and elimination in Africa. Knowledge gaps regarding An. stephensi ecology and behavior and the effectiveness of intervention methods in Africa have impeded the development of effective surveillance and control programs. This project will facilitate malaria control in Ethiopia by shedding light on An. stephensi biology, developing new surveillance tools, and identifying cost-effective vector control methods.

PI_NAMEs: YAN, GUIYUN  (contact)

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;African;Anopheles Genus;anthropogenesis;Antibody Response;Area;Asia;Basic Science;Behavior;Behavioral Genetics;Biological Factors;Biological Markers;Biology;burden of illness;Climate;cost effective;cost effectiveness;Country;Culicidae;Data;data management;Detection;Development;Djibouti;Ecology;Effectiveness;Effectiveness of Interventions;Environment;Environmental Risk Factor;Epidemiology;Ethiopia;exposed human population;Exposure to;Future;Genetic;Genetic Variation;Goals;Heterogeneity;Horns;Human;Incidence;Institution;Intervention;Invaded;Kenya;Knowledge;Light;Malaria;malaria transmission;Methods;microbial;Modeling;Nigeria;novel;Office of Administrative Management;Parasites;Parasitic infection;Peptides;Phylogenetic Analysis;Play;Population;Population Genetics;predictive modeling;programs;Public Health;public health relevance;Research Personnel;Risk;Role;Rural;Salivary Proteins;Serology;Site;Somalia;Sudan;Surveillance Methods;System;Testing;Time;tool;Translational Research;transmission process;Travel;urban area;Urbanicity;vector;vector control;vector mosquito

PROJECT_TITLE: Malaria Epidemiology and Vector Biology of Anopheles stephensi across Rural and Urban Landscapes in Ethiopia


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: CA

PROJECT_TERMS: Anopheles Genus;Biology;Biometry;Collaborations;data management;Ensure;Epidemiology;Ethiopia;experience;Federal Government;Fostering;Goals;Government;Government Agencies;Health;Immunology;Institution;Interdisciplinary Study;International;international center;Malaria;Monitor;Occupational activity of managing finances;outreach;Research;Research Activity;Research Personnel;Rural;Scientist;Structure;student training;success;Techniques;Time;timeline;transmission process;United States National Institutes of Health;Urbanization;vector

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Public Health Relevance The Data Management and Biostatistics Core will provide centralized data management for the two research projects of this ICEMR to enable timely data sharing, analysis and biostatistical support. The Core will provide training to students and scientists to enhance statistical and data management capacity in Ethiopia.

PI_NAMEs: LEE, MING-CHIEH  (contact)

PROJECT_TERMS: Address;Anopheles Genus;Archives;Biology;Biometry;Biostatistical Methods;Biostatistics Core;California;Clinical;Clinical Data;cloud based;complex data;Computer software;Country;Culicidae;Data;data acquisition;Data Analyses;data cleaning;Data Collection;data dictionary;data management;Data Management Resources;data quality;Data Security;Data Set;data sharing;data standards;Database Management Systems;deep sequencing;design;disease model;Ecology;Educational workshop;electronic data;Ensure;Epidemiology;Ethiopia;experience;field study;genomic data;Genomics;Goals;Guidelines;Human Resources;hydrology;improved;Information Systems;Institution;Laboratories;Malaria;member;Mentors;Methods;Modernization;Monitor;multidisciplinary;Nature;Play;Population;Population Analysis;Procedures;programs;protocol development;Public Health;public health relevance;public repository;Qualifying;Quality Control;remote sensing;Research;Research Design;Research Personnel;Research Project Grants;Role;Rural;Sample Size;Sampling;Scientist;sensor;Site;Source;Standardization;Statistical Data Interpretation;Statistical Methods;Stream;Structure;student training;Students;success;System;Technology;Terminology;tool;Training;United States;United States National Institutes of Health;Universities;Validation;vector;Vector Ecology;Weather;Work

PROJECT_TITLE: Data Management and Biostatistics Core


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Public Health Relevance This project will significantly improve our understanding of the biology of new invasive Anopheles stephensi and the impact on malaria vectorial system and malaria transmission in Africa. The project will develop new surveillance methods to track its spread and examine new control methods. This research will make a timely and significant contribution to the surveillance and control of the invasive An. stephensi in Africa.

PI_NAMEs: YEWHALAW, DELENASAW  (contact)

PROJECT_TERMS: Address;Adult;Africa;African;Anopheles Genus;anthropogenesis;Antibodies;Antibody Response;Asia;Bacillus;Bacillus thuringiensis;Behavior;Behavioral Genetics;Biological Factors;Biological Markers;Biology;Bite;Culicidae;Data;Detection;Development;Djibouti;dosage;Ecology;Effectiveness of Interventions;Environment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Epidemiology;Ethiopia;evidence base;Evolution;exposed human population;Exposure to;Frequencies;Future;Genetic;genetic analysis;Habitats;Human Volunteers;immunogenicity;improved;Influentials;Insecticides;Invaded;Kenya;Knowledge;Malaria;malaria transmission;Methods;microbial;Microsatellite Repeats;Middle East;Mitochondria;Monitor;Nigeria;Organism;Parasites;Peptides;peri-urban;Plasma;Plasmodium falciparum;Plasmodium vivax;Play;Population;Population Dynamics;Population Genetics;Predictive Factor;Predisposition;Procedures;programs;public health relevance;Reapplication;Research;Resistance;Rest;risk stratification;Role;Rural;rural area;rural environment;Salivary;Salivary Proteins;Sampling;Serology;Site;Somalia;Specificity;Sudan;Surveillance Methods;synergism;System;Testing;Time;tool;transmission process;urban area;urban setting;Urbanicity;vector;vector control;Vector Ecology;vector mosquito;World Health Organization

PROJECT_TITLE: Vector Biology of Invasive Anopheles stephensi in Rural to Urban Landscapes in Ethiopia


NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Public Health Relevance This project will significantly improve our understanding of the impact of Anopheles stephensi invasion on malaria risk across rural and urban landscapes, and identify more cost-effective malaria vector control methods in Ethiopia. This research will improve malaria control in Africa where the newly invaded An. stephensi species poses a major public health threat.

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;African;Anopheles Genus;Anti-malarial drug resistance;Antibody Response;Antigens;Area;Biological Markers;Biology;burden of illness;Case/Control Studies;Clinical;Communities;cost effective;cost effectiveness;Country;Culicidae;Data;deep sequencing;density;Detection;Development;Disease;Epidemiology;Ethiopia;Ethiopian;evidence base;Exposure to;Frequencies;genetic analysis;Genetic Structures;Genetic Variation;Health;Heterogeneity;high risk;high risk population;Hospitals;Household;Human;improved;Incidence;Indigenous;Individual;Infection;insight;Invaded;Knowledge;land cover;land use;Malaria;malaria infection;malaria transmission;Measures;Methods;microbial;Microsatellite Repeats;Monitor;Mutation;Outcome Measure;Parasites;Parasitic infection;Pattern;Plasma;Plasmodium falciparum;Plasmodium vivax;Population;Population Genetics;Predisposition;Process;programs;Public Health;public health relevance;relative cost;Research;response;Risk;Risk Factors;Rural;rural area;Salivary Proteins;Sampling;seroconversion;Serology;Site;synergism;Target Populations;Time;transmission process;Travel;urban area;urban setting;Urbanization;Validation;vector;vector control;Vector Ecology;World Health Organization

PROJECT_TITLE: Malaria Epidemiology across Rural and Urban Landscapes in Ethiopia


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pregnancy is a high-risk time for acquiring HIV; pre-exposure prophylaxis (PrEP) is an effective, woman- controlled, evidence-based intervention that is recommended during pregnancy in high-risk settings. In Kenya, PrEP is being delivered in some regions during pregnancy and postpartum integrated into maternal and child health services, but scale-up has been sub-optimal. This project aims to develop a community of practice; then test a combination of community of practice, quality improvement, and a training toolkit, to enhance implementation and clinical outcomes; and identify patterns attributes associated with successful implementation.

PI_NAMEs: KINUTHIA, JOHN ;WAGNER, ANJULI DAWN (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Adoption;African;AIDS prevention;antenatal care;Automobile Driving;Clinic;Clinical;Collaborations;Community of Practice;cost;Country;County;Data;design;Development;economic evaluation;Environment;Evidence based intervention;experience;Goals;Guidelines;Health;Health Personnel;Health Services Accessibility;Heterogeneity;high risk;HIV;Hospitals;implementation fidelity;implementation outcomes;implementation process;implementation science;implementation strategy;improved;Incidence;infant infection;Infrastructure;innovation;Institution;Intervention;Interview;Joints;Kenya;Knowledge;knowledge integration;Leadership;Learning;Maintenance;Maternal and Child Health;Maternal-Child Health Services;Measures;meetings;member;Mentorship;Methods;Outcome;Patient-Focused Outcomes;Pattern;peer;Penetration;Policies;Population;Positioning Attribute;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;pregnant;Pregnant Women;primary outcome;Problem Solving;Process;programs;Readiness;Recommendation;Recording of previous events;Regression Analysis;Research;response;Risk;scale up;Scanning;Science;secondary outcome;Services;Site;Structure;success;Surveys;Testing;theories;Time;Tracer;Training;Universities;Vertical Transmission;Washington;Woman;World Health Organization

PROJECT_TITLE: Scaling up integrated PrEP delivery in Kenyan maternal and child health clinics for pregnant and postpartum women

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The research outlined in this proposal will lead to new mechanistic and structural insights into the functioning of bacterial protein organelles – complex megadalton protein assemblies – and their roles in bacterial metabolism, stress resistance, nutrient utilization, and pathogenicity. This research will lay the groundwork for future therapeutic approaches aimed at disrupting protein organelle function to reduce microbial fitness and pathogenicity. Additionally, this work will generate the necessary fundamental knowledge for co-opting protein organelles for future biomedical applications ranging from improving the biological production of drugs to drug delivery and bioimaging.

PI_NAMEs: GIESSEN, TOBIAS WOLFGANG (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: Protein Organelles In Human-Associated Bacteria

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEW YORK

ORG_NAME: DELIBERATE SOLUTIONS, INC.

ORG_STATE: NY

PHR: The Depression and Anxiety AI-COA™ is a Drug Development Tool (DDT-IST-000014) that uses machine learning to analyze audiovisual signals of clinical interviews and infer HAM-D and HAM-A scores, which will increase power in clinical trials and will get novel therapeutics to market faster, cheaper and safely; ultimately reducing the disease burden to society. The proposed research project will augment the pilot dataset to ensure a more representative sample, re-train the AI-COA™ model, and evaluate its performance and generalizability across different subgroups. The results will reduce uncertainty regarding the design and dimensions of a confirmatory trial that will be proposed in the Qualification Plan (QP) phase.

PI_NAMEs: AAFJES, MARC  (contact);COHN, JEFFREY F

PROGRAM_OFFICER_NAME: TOMITA, YORK

PROJECT_TITLE: DDT-IST-000014: Progressing towards the Qualification Plan of AI-COA™ for Automated Depression and Anxiety Severity Measurement

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-S (12)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Nutrition

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Candida spp. is the most common cause of invasive fungal infections among individuals living with HIV and oropharyngeal candidiasis (OPC) is the most frequent opportunistic infection in HIV-infected individuals. We propose the evaluation of hydrogels loaded with two natural compounds with activity against Candida spp. These studies have the potential to develop local treatments that will deliver natural compounds to prevent and treat oral candidiasis.

PI_NAMEs: MYLONAKIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: absorption;Adhesions;Adhesives;Advanced Development;anti-cancer;anti-fungal agents;Anti-Inflammatory Agents;anti-microbial peptide;Antibiotic Resistance;antimicrobial;Antioxidants;antiretroviral therapy;Artificial Saliva;Azoles;beta-defensin 3;Biological;Biological Assay;Biomass;Caenorhabditis elegans;caffeic acid phenethyl ester;Candida;Candida albicans;Candida auris;Candidiasis;Categories;Cell Line;Cell Wall;Centers for Disease Control and Prevention (U.S.);Certification;chemokine;Classification;Clinical;Collaborations;combat;Cream;cytotoxicity;Data;Death Rate;Defensins;Development;drug discovery;Drug resistance;drug resistant pathogen;Drug Targeting;Ellagic Acid;Epithelial Cells;Epithelium;Erythrocytes;Evaluation;Filament;Film;Formulation;Fungal Drug Resistance;gellan;Goals;Growth;Health;HIV;Human;Hydrogels;Hyphae;Immune;Immune response;Immunologist;immunoregulation;Impairment;In Vitro;Individual;Inflammatory Infiltrate;Insecta;Internal Medicine;Invaded;Invertebrates;Larva;Lesion;Mediating;Metabolic;Microbial Biofilms;microorganism;Minimum Inhibitory Concentration measurement;Modeling;mouse model;Mucosal Immunity;Mucous Membrane;Multiple Fungal Drug Resistance;Mus;Mycoses;Natural Compound;novel;Opportunistic Infections;Oral candidiasis;Oral cavity;oral immunity;oral microbiome;Oral mucous membrane structure;Oropharyngeal;oropharyngeal thrush;Palate;pathogen;pathogenic fungus;Pharmaceutical Preparations;Phase;Phase 0/1 Clinical Trial;Phospholipase;plant metabolites;Plants;polyphenol;prevent;Production;Property;Protocols documentation;Publishing;Research Priority;resistant strain;safety study;School Dentistry;secondary metabolite;side effect;Source;Surface;Testing;Therapeutic;Tissues;Tongue;Toxic effect;Translations;Treatment Failure;United States;United States National Institutes of Health;volunteer;Yeasts

PROJECT_TITLE: Natural Phenolic Compounds against Oral Candidiasis (OC)

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The patients infected with HIV require lifelong treatment with antiretroviral drugs. Integrase inhibitor (INI) based two-drug regimen such as dolutegravir-rilpivirine is effective for HIV therapy whereas cabotegravir-rilpivirine intramuscular long-acting nanosuspension is available for HIV prevention and therapy. However, both dolutegravir and rilpivirine have low and fatty meal dependent oral bioavailability and injectable cabotegravir- rilpivirine nanosuspension is invasive and cannot be self-administered. This project will develop novel strategies to improve oral and transdermal delivery of dolutegravir-rilpivirine combination for non-invasive and effective management of HIV infections and for HIV prophylaxis.

PI_NAMEs: DATE, ABHIJIT A (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: absorption;Acids;Address;Adverse effects;age group;AIDS prevention;Amino Acids;amphiphilicity;Anions;Anti-Retroviral Agents;antiretroviral therapy;BAY 54-9085;Biodistribution;Biological Availability;Biological Products;biomaterial compatibility;Brain;Carnitine;Cations;chemical stability;Childhood;Clinical;Cold Chains;cost;Country;Cutaneous Administration;Data;Development;Diabetes Mellitus;Dose;drug clearance;Drug Combinations;Drug Kinetics;Drug Utilization;Enhancers;Evaluation;Exhibits;experience;Fatty acid glycerol esters;Food;Formulation;gastrointestinal;Gel;Generations;Grant;Health Personnel;health training;HIV;HIV Infections;HIV therapy;Human;Hydrophobicity;Ibuprofen;improved;In Vitro;Incidence;inhibitor;Injectable;Integrase Inhibitors;inter-individual variation;Intramuscular;Lipids;Liquid substance;lymph nodes;melting;Membrane;Metabolic Diseases;Modeling;Mus;nano;nanoemulsion;nanoformulation;Needlestick Injuries;non-nucleoside reverse transcriptase inhibitors;novel strategies;Oleic Acids;Oral;Oral Characters;Patient Compliance;Patients;Permeability;Pharmaceutical Preparations;pill;Population;preclinical study;Prevention;Process;Property;Prophylactic treatment;Regimen;Research;Resource-limited setting;Reverse Transcriptase Inhibitors;Route;Safety;Salts;Self Administration;side effect;Skin;social stigma;Solubility;Suspensions;System;Tablets;Technology;Temperature;Testing;Therapeutic;Tissues;Vagina;Viral Physiology

PROJECT_TITLE: Ionic liquid-based nanoemulsion containing combination antiretroviral drugs for the oral and transdermal treatment of HIV infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: PROVO

ORG_DEPT: CHEMISTRY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Single-cell biochemical analysis greatly benefits biomedical research by providing insights into tissue microenvironments, interactions between cell types and specific responses to therapies that cannot be determined using bulk measurements. While unbiased single-cell proteomics has advanced rapidly in recent years, few efforts have been made to extend these measurements to post-translational modifications or to other classes of biomolecules that are readily profiled by mass spectrometry. We will develop technologies for mass spectrometry-based single-cell biochemical analysis beyond the global proteome, which is expected to have a transformative impact on biomedical research.

PI_NAMEs: KELLY, RYAN T (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Biochemical;Biological;Biomedical Research;cell growth regulation;Cell Physiology;cell type;Cells;Complex;Diagnostic;effective therapy;Exhibits;Experimental Designs;Genotype;Heterogeneity;improved;insight;instrument;Label;lipidome;Lipids;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Measurement;Mediating;metabolome;Molecular;nano;new technology;novel;Nucleic acid sequencing;Phase;Phenotype;Phosphorylation;Post-Translational Protein Processing;protein expression;protein profiling;Proteins;Proteome;Proteomics;Research;Sampling;single cell analysis;Technology;Tissues;treatment response

PROJECT_TITLE: Mass Spectrometry-Based Biochemical Analysis of Single Cells Beyond the Global Proteome

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Microbiome;Nutrition;Pediatric;Pediatric - AIDS;Pneumonia and Influenza;Prevention;Vaccine Related;Women's Health Research

PHR: This project will study immune responses to vaccines from birth to 6 years of age in an ongoing cohort of Kenyan children. We will conduct longitudinal modelling of antigen-specific antibody and T cell responses to determine whether maternal immune activation and early-life exposure to the immune-modulating viruses HIV and cytomegalovirus (CMV), as well as other co-infections, nutrition, and intestinal inflammation, affect vaccine- induced immune responses from birth through middle childhood. These data will inform improved vaccination strategies for children living in areas with a high prevalence of HIV, CMV and malnutrition.

PI_NAMEs: DAY, CHERYL LIANE;SLYKER, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: CHIOU, CHEN-CHIA CHRISTINE C

PROJECT_TERMS: 4 year old;5 year old;6 year old;Affect;African;Age Months;Antibodies;Antibody Response;antigen-specific T cells;Antigens;Area;Automobile Driving;Birth;Breast Feeding;Cellular Immunity;Child;Child Mortality;Childhood;Clinical Data;co-infection;cohort;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Data;Diphtheria;Documentation;early childhood;early life exposure;Enteral;Enzyme-Linked Immunosorbent Assay;Exposure to;follow-up;Frequencies;Growth;gut dysbiosis;gut inflammation;gut microbiome;Haemophilus influenzae type b;Hepatitis B;Heterogeneity;High Prevalence;high risk;HIV;HIV Infections;Human poliovirus;Humoral Immunities;Immune;immune activation;Immune response;Immune system;immunoregulation;Impairment;improved;in utero;infancy;Infant;infant infection;Infection;Infection Control;Inflammation;Influenza;Influenza vaccination;influenza virus vaccine;Intervention;Life;Malnutrition;Maternal antibody;Measles;Mediating;microbiome;middle childhood;Modeling;novel;nutrition;Nutritional status;Pertussis;Population;Postpartum Period;Poverty;Pregnancy;Prevalence;preventable death;Records;Reporting;Research;response;Risk;Rotavirus;sample collection;seasonal influenza;sex;single-cell RNA sequencing;Stains;Streptococcus pneumoniae;systemic inflammatory response;T cell response;T-Lymphocyte;Tetanus;tool;Vaccination;vaccination schedule;vaccination strategy;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Viremia;virome

PROJECT_TITLE: Identifying critical determinants of vaccine-induced cellular and humoral immunity from birth through childhood in HIV-exposed and unexposed children


ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Progress in reducing the burden of malaria has recently stalled and even reversed course in some of the highest burden countries of Africa, including Uganda. New strategies are urgently needed to respond to emerging threats including the use of multiple sources of data to better understand malaria risk at the sub- national level and target interventions. The central theme of our program will be to improve malaria surveillance to better assess the impact of malaria control interventions and guide evidence-based utilization of interventions to reduce the malaria burden using an adaptive approach.

PI_NAMEs: DORSEY, MATTHEW G (contact);KAMYA, MOSES ROBERT

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Address;Africa;African;Anti-malarial drug resistance;Artemisinins;asexual;Beds;Behavior;Behavioral;Biological Assay;Cessation of life;Child;Clinical Data;Collaborations;Communities;Community Surveys;Country;COVID-19 pandemic;Culicidae;Data;detection assay;Diagnostic;Drug resistance;Epidemiology;evidence base;Evolution;feeding;Formulation;Funding Mechanisms;Future;Genomics;Genotype;global health;Health care facility;Household;Human;Immunology;Impact evaluation;improved;Insecticide Resistance;Insecticides;international center;Intervention;Knowledge;Laboratories;Link;Longitudinal Studies;Malaria;malaria transmission;Measures;Mediating;member;Membrane;Microscopic;Modeling;Molecular;Molecular Epidemiology;Monitor;multiple data sources;Mutation;novel;Parasitemia;Parasites;Patients;Policies;programs;pyrethroid;Research;Research Project Grants;Residual state;Resistance;Resources;response;Risk;Rotation;sample collection;Sampling;scale up;School-Age Population;Serology;Site;Specimen;surveillance data;Surveillance Program;System;Target Populations;Time;tool;trait;transmission process;trend;Uganda;vector;Work

PROJECT_TITLE: Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: DORSEY, MATTHEW G (contact)

PROJECT_TERMS: Area;Award;California;Collaborations;Communication;Complex;Coordination and Collaboration;Country;Educational workshop;Electronic Mail;Ensure;European;experience;Foundations;Funding Agency;Goals;Group Meetings;Health;Human;Human Resources;human subject;Immunology;Infectious Diseases Research;Institution;Institutional Review Boards;International;Leadership;Location;Malaria;material transfer agreement;meeting reports;meetings;member;Modeling;operation;Output;Persons;Policies;Policy Maker;programs;Publications;Recommendation;Research;Research Activity;research data dissemination;Research Personnel;Research Project Grants;Resistance;Resources;Running;San Francisco;scientific organization;Services;Site;Solid;Specimen;success;Sum;symposium;training project;Training Support;Transportation;Travel;Uganda;Universities;virtual;Visit;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PI_NAMEs: LAVOY, GEOFFREY  (contact)

PROJECT_TERMS: Africa;Aliquot;analytical method;archive data;Biological;Biometry;Biostatistics Core;Clinical;Clinical Data;Collaborations;Communities;Computers;cost;Data;data acquisition;data archive;Data Collection;Data Coordinating Center;data integration;data management;data quality;Databases;design;diverse data;Ensure;Environment;Epidemiology;Equipment and supply inventories;European;Evaluation Research;experience;Faculty;flexibility;Future;Goals;HIV;Human Resources;Immunology;Individual;International;Internet;Investments;Laboratories;Laboratory Study;Location;Malaria;Manuscripts;Mentors;Metadata;Methodology;Methods;Modeling;Monitor;Outcome Study;Population Heterogeneity;Preparation;Program Research Project Grants;programs;Protocols documentation;public database;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Sample Size;Sampling;Secure;Security;Sentinel;Services;Shipping;Site;Socioeconomic Factors;Specimen;Standardization;statistical service;success;surveillance data;System;Testing;Time;tool;Training;Tuberculosis;Uganda;United States National Institutes of Health;web server;Work

PROJECT_TITLE: Data Core


NIH_SPENDING_CATS: Clinical Research;Health Services;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: NANKABIRWA, JOANITER IMMACULATE (contact)

PROJECT_TERMS: African;Anti-malarials;Area;Artemisinins;Award;Biological;burden of illness;Case Management;Chemoprevention;Cluster randomized trial;Collaborations;Communities;Community Surveys;Country;Cross-Sectional Studies;Data;Decision Making;demographics;density;design;Diagnostic;Disease;Ensure;Epidemiology;Evaluation;experience;Folic Acid Antagonists;Funding;Future;Generations;Government;Health care facility;health data;health seeking behavior;Household;Immunology;Impact evaluation;improved;Incidence;Individual;Infection;Insecticide Resistance;Insecticides;Intervention;Laboratories;Malaria;malaria transmission;Malaria Vaccines;Measures;member;Modeling;Molecular Epidemiology;molecular marker;Monitor;Morbidity - disease rate;Outcome;Outpatients;Pharmaceutical Preparations;Policies;Population;Practice Management;Prevalence;programs;Quasi-experiment;Random Allocation;Reporting;Research Design;Residual state;Resistance;Resource Allocation;Resources;response;Running;rural area;Sampling;scale up;Seasons;Series;surveillance data;surveillance network;Surveys;Time;trend;Uganda;vector;vector control;Work

PROJECT_TITLE: Surveillance and Impact Evaluation Project


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: NSOBYA, SAM  (contact)

PROJECT_TERMS: Anopheles Genus;Anti-malarial drug resistance;Anti-malarials;Artemisinins;Carbamates;Chemoprevention;Combined Modality Therapy;Culicidae;deep sequencing;Development;Disease;disorder prevention;Drug Metabolic Detoxication;Drug resistance;Enzymes;experimental study;feeding;Folic Acid;Genetic Polymorphism;Genomics;high risk population;Household;Human;Immunology;Incidence;Individual;Insecticide Resistance;Insecticides;insight;Intervention;Malaria;malaria infection;malaria transmission;Measures;Mediating;Mediator;Membrane;Metabolism;Metadata;Methods;Modeling;Mutation;Organophosphates;Parasite resistance;Parasites;Performance;Pharmaceutical Preparations;Point Mutation;Policy Maker;Predisposition;Prevalence;prevent;Production;programs;pyrethroid;Regimen;Residual state;Resistance;Resistance development;resistance mechanism;Risk;Sampling;Site;surveillance network;Surveys;Testing;Time;tool;transmission process;Treatment Protocols;Uganda;vector;vector control;Vertebral column

PROJECT_TITLE: Resistance Project


NIH_SPENDING_CATS: Clinical Research;Genetics;Immunization;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: SSEWANYANA, ISAAC  (contact)

PROJECT_TERMS: Africa;Antibodies;Antibody Response;Antigens;Area;Beds;Biological;burden of illness;Case Study;co-infection;Complex;Country;Cross-Sectional Studies;Data;Diagnostic;diagnostic strategy;Diagnostic tests;DNA;epidemiologic data;Epidemiology;evidence base;Genetic;genomic data;Genotype;Haplotypes;Health care facility;Horns;Human;Immune Evasion;Immunoglobulin G;immunological intervention;Immunology;Incidence;Infection;Insecticides;Intervention;Investments;Link;Malaria;Malaria Diagnosis;malaria infection;Measures;Microscopy;Modeling;Molecular;Molecular Epidemiology;Parasites;Parasitic infection;Plasmodium falciparum;Policies;Population;pressure;Prevalence;programs;Public Health Practice;Rapid diagnostics;Residual state;Resistance;response;sample collection;Sampling;Serology;Serology test;Site;Testing;Time;tool;transmission process;Uganda;vaccine distribution;Vaccines;vector control

PROJECT_TITLE: MOLECULAR EPIDEMIOLOGY


ADMINISTERING_IC: CK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative. This project addresses issues of critical importance to management of vector-borne disease (VBD) in the United States, including those caused by viruses transmitted by mosquitoes (West Nile) as well as tick-borne pathogens like Borrelia burgdorferi (Lyme Disease). Because the upper Midwest is a national hotspot for Lyme Disease and other tick-borne diseases and is notable for endemic transmission and periodic epidemics of West Nile and Eastern Equine Encephalitis viral diseases, we believe the Midwest Center of Excellence for Vector-borne Disease (MCE-VBD) is ideally positioned to address these challenges. The Center is a truly regional organization covering Wisconsin, Minnesota, Illinois, Michigan, Indiana, and Iowa. Center activities will focus the efforts of a formidable group of nationally recognized public health entomologists, epidemiologists, public health experts, and public and private vector control leaders to improve prevention and control practices. The goals include testing and improving existing methods of mosquito and tick management and bite prevention, evaluating new products and methods, supporting the training of the next generation of medical/public health entomologists, and enhancing a strong community of practice. Our efforts will engage academics, public health partners, public vector control agencies, and private pest control operators. Results and conclusions will be directly relevant to both the major VBD issues of the region as well as broadly applicable to public health entomology in the United States.

PI_NAMEs: PASKEWITZ, SUSAN M (contact)

PROJECT_TITLE: CK22-005, The Midwest Center of Excellence for Vector-Borne Disease


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed project will unfold though a community-based participatory research process that will be responsive to feedback from impacted communities about how Extreme Risk Protection Orders (ERPOs) are implemented and the need for ERPO implementation processes that recognize the fractured relationships between impacted communities and law enforcement. We will develop an implementation strategy for agencies and organizations to use to implement ERPO in a just and equitable manner.

PI_NAMEs: FRATTAROLI, SHANNON  (contact);ZEOLI, APRIL M

PROJECT_TITLE: RFA-CE-22-004, Developing and evaluating an extreme risk protection order implementation protocol with impacted communities


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The Pacific Southwest Center Excellence in Vector-Borne Diseases (PacVec) offers an opportunity to address an urgent and compelling public health challenge—the ongoing rise in vector-borne diseases, particularly those transmitted by mosquitoes and ticks—by leveraging the resources of seven leading research and teaching institutions that have well-established partnerships with mosquito control and public health agencies around our region. Together, we propose a center that is responsive to and reflective of the needs of the broader US Southwest population, with applied research to advance methods to prevent the spread of vector-borne diseases and to train a culturally diverse “community of practice” including public-health scientists and other professionals.

PI_NAMEs: BARKER, CHRISTOPHER M (contact)

PROJECT_TITLE: CK22-005, Pacific Southwest Center of Excellence in Vector-Borne Diseases


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE Current ways of collecting employee injuries greatly underestimate the true numbers and risk involved. Our work will improve upon current methods by actively reaching out to healthcare workers to report physical injuries, near-misses, and other health effects by means of a user-friendly mobile application. We will also design a system that will combine information from employee injuries with risk factors from the patient care environment to provide early warnings about high risk areas – leading to improving the health and safety of healthcare workers and can be applied to other industries interested in improving worker safety.

PI_NAMEs: DARAISEH, NANCY M. (contact);MACALUSO, MAURIZIO

PROJECT_TITLE: Enhanced injury surveillance using real-time reporting among healthcare workers

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOZEMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Everyone uses the cartilage in their joints for daily activities like walking. Understanding how cartilage responds to the compressions caused by movement will advance basic understanding of the musculoskeletal system. The project is relevant to the mission of NIH, NIA, and NIAMS because it will 1) provide a basic understanding of how chondrocytes respond to mechanical compression and 2) address the question of how compression affects chondrocyte energy utilization. These advances are likely to identify candidate biochemical reactions for drugs to repair and grow cartilage.

PI_NAMEs: JUNE, RONALD KENT (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acids;Address;Affect;Age;Aging;Amino Acids;Animals;Basic Science;Biochemical Reaction;Biological;Biological Assay;Biological Models;Biology;blood glucose regulation;Body Weight decreased;bone;bone cell;candidate identification;Carbon;Cartilage;Cartilage Matrix;cartilage repair;cell injury;cell type;Cells;Chondrocytes;Citric Acid Cycle;Clinical;Complex;Data;Degenerative polyarthritis;Deterioration;Drug Targeting;Elderly;Energy-Generating Resources;Environment;Enzyme Inhibitor Drugs;Evaluation;Exercise;experimental study;Future;Glucose;glucose metabolism;Glutamine;Glycolysis;Goals;healing;Health;Histopathology;Human;Impairment;improved;In Vitro;in vivo;Individual;Inflammatory Response;inhibitor;Injury;innovation;insight;Isotope Labeling;Isotopes;joint destruction;joint function;joint injury;joint loading;joint mobilization;Joints;Knowledge;Link;Liquid substance;Mass Spectrum Analysis;mechanical drive;mechanical force;mechanical load;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mission;Modeling;Molecular;Motion;Movement;Mus;Musculoskeletal System;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new therapeutic target;Non-Essential Amino Acid;novel;Outcome;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Pentosephosphate Pathway;Periodicity;Pharmaceutical Preparations;Physiological;pre-clinical;pre-clinical research;Process;Production;Proteins;Quality of life;Reaction;reaction rate;Reference Values;Regulation;repaired;Replacement Arthroplasty;Respiration;respiratory;response;Role;Running;sex;Signal Transduction;small molecule inhibitor;Source;Stains;Symptoms;Synovial joint;Synovial Membrane;Systems Biology;Testing;Time;Tissues;Translating;translational approach;Translations;United States National Institutes of Health;viscoelasticity;Walking

PROJECT_TITLE: Role of Glucose metabolism in Chondrocyte Mechanotransduction

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Obesity;Prevention;Substance Misuse

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: Project Narrative Bariatric surgery is the most effective treatment for severe obesity, yet more than 20% of individuals experience an alcohol use disorder after surgery due to metabolic and behavioral changes. Despite significant risks of problematic alcohol use among a growing number of individuals undergoing bariatric surgery, there is a lack of knowledge regarding the factors associated with post-surgical alcohol use. The proposed study moves the field forward and impacts public health by identifying the distal and proximal factors that contribute to re- initiation of and episodic alcohol use following bariatric surgery, which could lead to effective interventions to reduce post-surgical alcohol use and prevent the development of an alcohol use disorder.

PI_NAMEs: MATERO, LISA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: absorption;acceptability and feasibility;Affect;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Anger;Anxiety;Area;bariatric surgery;Behavior;Behavioral;coping;coping mechanism;Data;design;deter alcohol use;Development;Distal;drinking;Eating;Eating Behavior;Ecological momentary assessment;effective intervention;effective therapy;Emotional;emotional eating;Emotions;Enrollment;experience;Feedback;follow-up;Food;Frequencies;Future;Goals;Grant;hazardous drinking;Heavy Drinking;high risk;Hormones;improved;Incidence;Individual;innovation;Intervention;Interview;Knowledge;Measurement;Measures;meetings;Mental Depression;Metabolic;Metabolism;Methods;Mission;Moods;Morbid Obesity;negative mood;Operative Surgical Procedures;Participant;Pathway interactions;patient engagement;patient population;Patients;Phase;Physiological;Population;Prevalence;prevent;prospective;Protocols documentation;Public Health;Randomized;Recording of previous events;recruit;reduced alcohol use;Reporting;Research;Research Design;Research Project Grants;response;retention rate;Rewards;Risk;substance use;Surveys;Symptoms;Time;United States National Institutes of Health;weight loss intervention

PROJECT_TITLE: Identifying Factors Influencing Alcohol Use after Bariatric Surgery: An Ecological Momentary Assessment

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Project Narrative: Upon the successful completion of this proposal, we expect to make contributions to the scientific community at large by introducing an innovative ligand discovery platform to selectively identify nucleic acid ligands against cell surface targets, followed by developing programmable synthetic ligands study to cell surface receptor proteins.

PI_NAMEs: MALLIKARATCHY, PRABODHIKA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Discovery and development of artificial nucleic acid ligands to probe cellular interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Bacteria are known to generally lack membrane-bound organelles and were assumed to be disorganized. However, we discovered that bacteria contain non-membrane bound organelles called “biomolecular condensates” which organize their biochemical pathways. Therefore, by determining the mechanisms of bacterial “biomolecular condensates” we could identify novel antibiotic targets to combat rising drug resistance.

PI_NAMEs: SCHRADER, JARED MICHAEL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Antibiotics;Bacteria;Bacterial RNA;Binding;Biochemical Pathway;Biochemistry;Bioinformatics;Biology;Caulobacter crescentus;Cells;Characteristics;combat;Complex;Drug resistance;Enzymes;experimental study;In Vitro;in vivo imaging;Liquid substance;Location;Membrane;novel;Organelles;Organism;pathogen;Pathogenicity;Perception;Phase;Physical condensation;physical process;public health relevance;RNA Decay;Structure;Textbooks

PROJECT_TITLE: Biomolecular Condensates as Organizers of Bacterial RNA Biology

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Microbiome;Psoriasis;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Psoriatic Spectrum Diseases (PSD), which includes psoriasis and psoriatic arthritis, affects over 8 million individuals in the United States and is associated with chronic pain and loss of function for many patients. We assembled a world class, multidisciplinary team of scientists in PSD to recruit patients with the goal of defining the disease pathways that promote skin and joint inflammation and joint damage through the analysis of molecular signatures in the blood, psoriatic plaques and joint tissues. We will perform state-of the-art technologies to gain knowledge about the key cell-cell interactions and immunologic molecules that promote inflammation and damage with the goal of identifying new therapeutic targets and develop targeted strategies to improve outcomes for patients with psoriasis and psoriatic arthritis.

PI_NAMEs: GUDJONSSON, JOHANN ELI;LIAO, WILSON ;OGDIE, ALEXIS R.;RITCHLIN, CHRISTOPHER TREVOR (contact);SCHER, JOSE U.

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Advertising;Affect;Aftercare;Autoimmune;Award;Bioinformatics;biomarker identification;Biopsy;Blood;Cell Communication;cell type;Cells;chronic pain;Chronic small plaque psoriasis;Clinical Data;clinical phenotype;Clinical Protocols;clinically relevant;cohort;Cohort Studies;Collaborations;Collection;Common Data Element;Communication;Consult;Coupled;Cues;Data;Data Collection;data sharing;Dermatologist;Development;Disease;Disease Pathway;disease phenotype;Elderly;Electronic Health Record;Enrollment;ethnic diversity;Exclusion Criteria;Fostering;Funding Opportunities;Genetic;Goals;gut microbiome;Human Resources;Immune;Immunologics;Immunologist;Immunology;improved;improved outcome;Individual;Inflammation;joint inflammation;joint injury;Joints;Knowledge;Knowledge Portal;Leadership;Link;lipidomics;loss of function;Lupus;Manuscripts;Measures;Mediating;Medicine;Michigan;microbial;microbiome;Molecular;Molecular Analysis;Molecular Profiling;multidisciplinary;multiple omics;new therapeutic target;oral microbiome;Participant;participant enrollment;Pathogenicity;Pathologist;Pathology;Patient Recruitments;Patient-Focused Outcomes;Patients;Personnel Management;Phenotype;phenotypic data;Physicians;Pilot Projects;programs;Proteomics;Protocols documentation;Psoriasis;Psoriatic Arthritis;Quality Control;racial diversity;recruit;repository;Research Personnel;Resolution;Rheumatoid Arthritis;rheumatologist;sample collection;Sampling;scale up;Science;Scientist;Site;Skin;skin microbiome;Standardization;statistics;Structure;success;synergism;Synovial Membrane;Systemic Lupus Erythematosus;Systems Biology;Technology;Testing;Tissue Banks;tissue processing;Tissue Sample;Tissues;Training;transcriptomics;treatment response;United States;Universities;Work

PROJECT_TITLE: ELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium


NIH_SPENDING_CATS: Breast Cancer;Cancer;Diabetes;Prevention;Women's Health Research

PHR: Public Health Relevance This proposal aims to determine key mechanisms by which altered cellular metabolism drives disease risk, for instance an up to 28% higher rate of breast cancer incidence in patients with type 2 diabetes. Our innovative solutions map events driven by the metabolism-linked protein modification O-GlcNAc with control over cellular timing and the cellular location in which they operate, filling critical existing gaps in knowledge that do not track spatiotemporal mechanistic aspects. We apply our “time and space” cellular tools to the oncogenic transcription factor NFkB to determine actionable therapeutic strategies for metabolism-linked cancer risk and establish a well-rounded research program to target fundamental and applied mechanisms able to link metabolism with human disease risks.

PI_NAMEs: FEHL, CHARLIE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Awareness;Biology;Breast Cancer Risk Factor;cancer risk;Cell Nucleus;Cells;Cellular Metabolic Process;Chemicals;Collaborations;Communities;Cytosol;Development;Diabetes Mellitus;diabetic patient;Disease;Disease Pathway;disorder risk;Drug Targeting;Endoplasmic Reticulum;Ensure;Event;Funding;Glucose;Glycobiology;Goals;Hour;Human;human disease;Hyperglycemia;Incidence;Industrialization;Inflammation;innovation;Insulin;insulin signaling;Knowledge;Label;Laboratories;Lead;Link;link protein;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Metabolic;Metabolic Diseases;Metabolism;Methods;Modification;Molecular;Molecular Probes;Morphologic artifacts;Movement;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Oncogenic;Output;Pathology;Patients;Photochemistry;Physiologic pulse;Physiological;Physiology;Post-Translational Protein Processing;Process;programs;Proteins;public health relevance;Publishing;Real-Time Systems;Reporting;Research;Resolution;Scientist;Sialic Acids;Signal Transduction;spatiotemporal;Specialist;Stress;Subcellular Spaces;success;sugar;System;technology development;Therapeutic;Time;tool;tumor metabolism;United States National Institutes of Health;Work

PROJECT_TITLE: Spatiotemporal tools to interrogate O-GlcNAc functions in cellular signaling


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: This R01 application proposes to develop and test a novel machine learning accelerated online adaptive replanning (MOLAR) solution for magnetic resonance imaging (MRI) guided adaptive radiation therapy through a unique academic and industry partnership. The MOLAR solution aims to fully account for interfraction variations, thereby substantially improving the accuracy and effectiveness of radiation therapy (RT) for cancer. This solution will enable clinicians to routinely practice “image-plan-treat”, a drastic departure from current practice and representing the future of RT delivery.

PI_NAMEs: PAULSON, ERIC S (contact)

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Accounting;Address;Adoption;Affect;Air;Anatomy;automated segmentation;base editing;bone;cancer radiation therapy;Clinic;Clinical;Collaborations;commercialization;cone-beam computed tomography;convolutional neural network;Dose;Dose Fractionation;Effectiveness;electron density;Electron Transport;forging;Future;Generations;Goals;Health Care Costs;Image;image guided;image guided radiation therapy;imaging modality;improved;Industry;industry partner;innovation;large datasets;Length;Location;Lung;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Maps;Methodology;Methods;Modality;neural network algorithm;Normal tissue morphology;novel;Organ;pancreatic cancer patients;Patients;Physiology;Process;prospective;prospective test;Quality of life;quantitative imaging;Radiation Oncologist;Radiation therapy;Research Personnel;routine practice;Shapes;Site;soft tissue;Speed;success;Surface;targeted treatment;Techniques;Testing;Texture;Therapeutic;Time;tool;Toxic effect;treatment response;tumor;Variant

PROJECT_TITLE: Machine learning accelerated on-line adaptive replanning


ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE All organisms make use of redox-based processes for energetic transformations that span the fundamental chemistry of living, as well as the protection of the organism from highly reactive radical-based species. Often these transformations are catalyzed by metal-containing cofactors such as iron-sulfur clusters and heme units that are bound within proteins and enzymes. Understanding the diversity of the strategies that nature makes use of in the design and function of such redox-catalysis is critical to understanding the biological chemistry of ourselves and pathogens alike.

PI_NAMEs: ELLIOTT, SEAN J (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Redox Cofactor Diversity in Enzymatic Superfamilies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sepsis;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: SHORT NARRATIVE Sepsis is one of the leading causes of death in the US, and African American/Black (AA/B) and LatinX people with sepsis experience lower quality of care and higher rates of complications and death compared with Non- Hispanic White (NHW) populations. We will develop and evaluate a coalition-based leadership intervention to equip eight health systems and their surrounding communities to name and address structural racism and drive measurable reductions in inequities in sepsis outcomes. Findings from the mixed-methods evaluation will be useful across sectors (within and beyond healthcare) seeking to address racial inequities in health outcomes for people with sepsis and other complex health issues.

PI_NAMEs: BOATRIGHT, DOWIN ;CURRY, LESLIE ;LINNANDER, ERIKA  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute myocardial infarction;Address;Administrator;Affect;African American;American;anti-racism;Antibiotics;Automobile Driving;Awareness;Basic Science;Black Populations;Black race;Caring;Cause of Death;Cessation of life;Chest;Clinic;Clinical;Clinical Management;Collaborations;college;Communities;community organizations;comparative;Complex;Data;Death Rate;Disparity population;Early identification;Evaluation;evidence base;experience;Feedback;follow-up;Foundations;Functional disorder;Genetic Predisposition to Disease;Health;Health Care Costs;health inequalities;Health system;Healthcare;Hospital Mortality;hospital readmission;Hospitals;Immune response;improved;Incidence;Inequity;Infection;innovation;Institution;Institutional Practice;instrument;Interruption;Intervention;Latinx;Latinx population;Leadership;leadership development;Learning;Life;Literature;Measurable;Measurement;Measures;Methods;Mission;mortality;Names;National Institute of General Medical Sciences;Not Hispanic or Latino;novel;Organ;Organizational Change;Organizational Culture;Outcome;Pathway interactions;Patient Preferences;Patients;Persons;Phase;Physicians;Play;Politics;Population;Positioning Attribute;Primary Prevention;Problem Solving;prospective;psychologic;Public Policy;Quality of Care;racial disparity;racial population;Reporting;Research;Risk;Risk Reduction;Role;Safety;Seminal;Sepsis;socioeconomic disadvantage;standard care;Standardization;stem;Structural Racism;Surveys;System;Time;Time Series Analysis;United States National Institutes of Health;Work

PROJECT_TITLE: Mitigating Structural Racism to Reduce Inequities in Sepsis Outcomes


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it develops and assess a novel strategy to improve treatment of individuals with Familial Hypercholesterolemia (FH), namely identifying and treating them through the blood donor program. Once this strategy is developed in this proposal, it can be rapidly disseminated to blood donor programs nationally, making an immediate impact on FH care. Thus, the proposed research is relevant to part of the NHLB’s mission to promote the prevention of heart disease.

PI_NAMEs: KHERA, AMIT  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Affect;Age;arm;autosome;Blood;Blood Donations;Blood donor;blood treatment;Caring;Charge;Cholesterol;Clinic;Clinical Trials;Communities;Community Physician;Consolidated Framework for Implementation Research;Coronary Arteriosclerosis;Country;Data;Databases;Development;Diagnosis;diagnostic criteria;Disease;disorder risk;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;evidence base;Familial Hypercholesterolemia;Family member;Feedback;General Population;Guidelines;heart disease prevention;Heterozygote;Home;Human Resources;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Individual;innovation;Interview;LDL Cholesterol Lipoproteins;Life;Lipids;Maps;Medical;medical specialties;meetings;Methods;Mission;multi-component intervention;Notification;novel;novel strategies;patient registry;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Population;Prevalence;primary outcome;Process;programs;Public Health;Randomized;randomized trial;Recommendation;Reporting;Research;Risk;screening;Services;Structure;System;Testing;Texas;theories;Time;United States;Work

PROJECT_TITLE: IMPLEMENTING MULTICOMPONENT INTERVENTIONS TO TREAT BLOOD DONORS WITH FAMILIAL HYPERCHOLESTEROLEMIA


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE Alcohol-related consequences during emerging adulthood continue to be a large public health concern. This career development award supports training and research to 1) examine impelling cues emerging adults experience surrounding alcohol related consequences and 2) develop and test the feasibility of an intervention that utilizes these cues to reduce consequences.

PI_NAMEs: HULTGREN, BRITTNEY  (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Accidental Injury;Address;Affect;aged;alcohol consequences;Alcohol consumption;alcohol cue;alcohol intervention;alcohol misuse;alcohol misuse prevention;alcohol myopia;alcohol relapse;alcohol related consequences;alcohol research;alcohol use disorder;alcohol-related death;Alcohols;Arousal;Attention;Awareness;Behavior;Behavioral;Behavioral inhibition;Blood alcohol level measurement;brief intervention;Clinical;Code;Cognitive Therapy;Complement;Coupled;Cues;Data;Data Collection;Decision Making;Development;Disadvantaged;Dose;drinking;emerging adult;emerging adulthood;experience;feasibility testing;Goals;improved;Individual;insight;Internet;Intervention;Interview;Intoxication;K-Series Research Career Programs;Knowledge;Lead;Location;Mentors;Methodology;Modeling;Moods;motivational enhancement therapy;Myopia;National Institute on Alcohol Abuse and Alcoholism;Online Systems;Persons;Phase;post intervention;prevent;programs;Protocols documentation;prototype;Public Health;Qualitative Research;relapse prevention;Research;Research Support;Sampling;satisfaction;Sexually Transmitted Diseases;skills;sobriety;Societies;Structure;Technology;Testing;Text Messaging;text messaging intervention;theories;therapy design;therapy development;Training;Training Programs;Training Support;United States;university student;Unsafe Sex;user centered design

PROJECT_TITLE: Changing Decisions During Drinking: Development of an Alcohol-Related Consequence Intervention for Emerging Adults


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Prevention;Regenerative Medicine;Tobacco;Tobacco Smoke and Health

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: NARRATIVE This proposal is to understand the repair mechanisms of cells that comprise the alveoli, which form gas exchange area of the lung damaged by cigarette smoking. Focusing on bioactive lipids and their metabolic control, we propose experiments to improve the ability of human lung endothelial cells to withstand the irreversible injury and loss from smoking. We designed experiments to test new therapeutic targets to repair the lung in emphysema models which are of clinical significance.

PI_NAMEs: PETRACHE, IRINA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Alveolar;Alveolus;Area;Autophagocytosis;Autophagosome;Blood-Air Barrier;Calcium;Cell Death;cell growth;cell injury;Cells;Ceramides;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke-induced;cigarette smoking;clinically significant;Coculture Techniques;Complex;Coupled;Data;design;detection of nutrient;Development;Disinhibition;Endothelial Cells;Ensure;Enzyme Inhibition;Epithelial Cells;Experimental Designs;experimental study;exposure to cigarette smoke;fitness;FRAP1 gene;functional outcomes;Gases;Gene Expression Regulation;gene network;Genomics;Glucosylceramides;Homeostasis;Human;Impairment;improved;Inhalation;Injury;Knowledge;Link;Lipids;Lung;lung injury;lung microvascular endothelial cells;lung repair;Lysosomes;Maintenance;Mediating;Membrane;Metabolic;Metabolic Control;Metabolism;metabolomics;Modeling;mouse model;new therapeutic target;novel;novel strategies;Organelles;Pathogenesis;Pathway interactions;pharmacologic;pre-clinical;Process;Proteins;Pulmonary Emphysema;Recycling;Regulation;repair model;repaired;restoration;Role;Sampling;Signal Transduction;Signaling Protein;Slice;Smoking;smoking exposure;Sphingolipids;Sphingosine;sphingosine 1-phosphate;Stress;Testing;three-dimensional modeling;transcription factor;Transgenic Organisms;Work

PROJECT_TITLE: Ceramide-Induced Destruction in Emphysema

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Stroke;Women's Health Research

ORG_CITY: JOHNSON CITY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative This grant examines how we can stimulate the formation of new brain cells after stroke by using pharmacological drugs to increase molecules that promote neurogenesis and block those which reduce it. We will also study how we can block blood vitronectin in females and the male hormone, testosterone, in males, as they seem to play a unique detrimental role in blocking new cell formation. We expect to identify new treatments to maximize new cell formation after stroke, with different treatments for women and men, which might extend beyond to treatments of other neurological disease.

PI_NAMEs: HAGG, THEO  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acetylcholine;Acute;Adult;Affect;Androgen Receptor;antagonist;Antibodies;Astrocytes;Binding;Blood;Brain;brain cell;Castration;cell type;Cells;Ciliary Neurotrophic Factor;cytokine;Data;experimental study;Female;Flutamide;follow-up;Funding;Genetic;genetic approach;Grant;Hepatocyte;Hormones;Human;IL6ST gene;improved outcome;In Vitro;in vivo;Inflammatory;inhibitor;Injections;insight;Interleukin-6;Ischemic Stroke;Knock-out;LIF gene;Ligands;Liver;male;Male Castration;MAPK8 gene;Measures;Mediating;men;Middle Cerebral Artery Occlusion;Molecular Target;Motor;Mus;Muscarinic Acetylcholine Receptor;Muscarinic Agonists;Nerve;nerve supply;Nervous System;Nervous System Disorder;neuroblast;neurogenesis;novel;old mice;p38 Mitogen Activated Protein Kinase;Pericytes;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Plasma;Play;Population;post stroke;Property;Prosencephalon;PTK2 gene;receptor;Regulation;Repression;response;Role;sex;sexual dimorphism;Signal Pathway;Signal Transduction;stem cell division;Stroke;subventricular zone;Testing;Testosterone;Translating;translational study;Vagotomy;Vagus nerve structure;Vitronectin;Woman;women's treatment;Work;young adult

PROJECT_TITLE: Targeting CNTF to increase adult forebrain neurogenesis

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

PHR: RELEVANCE TO PUBLIC HEALTH  Chronic postoperative pain is a poorly recognized potential outcome of surgery affecting millions of people every year, making it a significant public health problem. The goal of this project is to determine the efficacy of using the dynamic parameter of diffuse noxious inhibitory controls to predict who might be susceptible to developing chronic postoperative pain and understanding the mechanisms responsible for it. We anticipate the studies will provide genetic and phenotypic biomarkers to guide diagnosis and treatment decisions in chronic postoperative pain.

PI_NAMEs: TAYLOR, NORMAN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Acute;Affect;Amputation;Animal Model;biomarker identification;breast surgery;Cardiac Surgery procedures;Catecholamines;Cells;Chronic;chronic pain;congenic;consomic;demographics;Diagnosis;diffuse noxious inhibitory control;dopamine system;dopaminergic neuron;Economics;efficacious treatment;efficacy evaluation;Exhibits;experience;Exposure to;Genes;Genetic;Genetic Markers;Genetic Polymorphism;Genomic approach;Goals;Inbred Dahl Rats;Incidence;Methyltransferase Gene;midbrain central gray substance;Modeling;multimodality;neural circuit;Neurons;Nociception;novel;Operative Surgical Procedures;optogenetics;Outcome;Pain;Patients;Persistent pain;Persons;pharmacologic;phenotypic biomarker;Physiological;Postoperative Pain;Predisposition;prevent;Psychological Factors;Public Health;Rattus;Research;response;Risk;Risk Factors;Role;Serotonin;Spinal Cord;Sprague-Dawley Rats;Stimulus;surgery outcome;Testing;Thoracotomy;Variant

PROJECT_TITLE: Chronic postoperative pain: Genetic and Neural Circuit Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunotherapy;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Regenerative Medicine

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Severe trauma is the leading cause of death and disability in people below the age of 45, and despite advances in trauma care management, mortality and complication rates remain high. The proposed work is significant because successful restoration of immune homeostasis in combination with regenerative treatment strategies may be critical to improve patient outcomes following severe musculoskeletal trauma.

PI_NAMEs: GULDBERG, ROBERT E (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Age;Animal Model;Animals;Antibodies;Autopsy;Awareness;Biological Markers;Biological Response Modifiers;biomechanical test;bone;Bone Regeneration;cancer immunotherapy;Cause of Death;Cells;Clinic;Clinical;Clinical Treatment;combat wound;Complication;cost;cytokine;Data;design;Development;disability;dosage;Effector Cell;effector T cell;Environment;evaluation/testing;experience;Flow Cytometry;Functional Regeneration;Gold;healing;Histologic;Homeostasis;Human;Image;Immune;immune modulating agents;Immune response;Immune system;immunoengineering;Immunologic Markers;Immunologic Stimulation;immunoregulation;Immunosuppression;Immunosuppressive Agents;Impairment;improved;improved outcome;in vivo;in vivo regeneration;Infection;Inflammatory;Intervention;Knowledge;Length of Stay;Ligands;Malignant Neoplasms;Managed Care;microCT;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;mortality;Muscle;musculoskeletal injury;Myeloid-derived suppressor cells;nanoGold;nanoparticle;novel;Opportunistic Infections;Osteogenesis;Outcome;particle;Patient-Focused Outcomes;Patients;Persons;pre-clinical;Pre-Clinical Model;predictive marker;predictive modeling;Predisposition;Proteomics;radiological imaging;Rattus;receptor;regeneration function;regenerative;Regenerative response;regenerative treatment;Reporting;response biomarker;restoration;Role;Serum;silibinin;small molecule;success;Suppressor-Effector T-Lymphocytes;Survivors;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Trauma;trauma care;Trauma patient;Treatment Cost;treatment response;treatment strategy;Work

PROJECT_TITLE: Immunoengineering Strategies for Musculoskeletal Trauma

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE This project is focused on improving methods for gene therapy of Duchenne muscular dystrophy (DMD), a common and severe neuromuscular disorder. Our previous studies led to the development of micro-dystrophin and systemic delivery methods. Current efforts focus on enhancing gene delivery and targeting, persistence of gene therapy and reversibility of dystrophy.

PI_NAMEs: CHAMBERLAIN, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Abnormal Cell;Address;adeno-associated viral vector;adenovirus mediated delivery;Adipocytes;Adolescent;Adult;Affect;Aging;Animal Model;animal old age;Animals;Area;Binding;Biological Sciences;Biotechnology;boys;Canis familiaris;Capsid;cellular transduction;Child;Clinical Trials;cost;Data;delivery vehicle;design;Development;Disease;Dose;Duchenne muscular dystrophy;Dystrophin;Eligibility Determination;Encapsulated;Fibrosis;Functional disorder;Future;Gene Delivery;Gene Targeting;gene therapy;Gene therapy trial;Genes;Genetic Diseases;Genetic Enhancer Element;Grant;Human;Human Genetics;Immunologics;improved;Infusion procedures;Investigation;Libraries;Ligands;Liver;Maintenance;mature animal;Mediating;Messenger RNA;Methods;micro-dystrophin;miniaturize;Modification;Monitor;Morphology;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Myopathy;Names;Natural regeneration;Neuromuscular Diseases;novel;Nucleocapsid;old mice;Outcome;particle;Pathology;Peptides;Phenotype;preclinical study;prevent;Production;promoter;Safety;scale up;screening;self assembly;Serotyping;Skeletal Muscle;Solid;stem cells;Striated Muscles;Structure;Surface;System;technology development;Testing;Time;Tissues;Transgenic Organisms;Treatment Efficacy;vector;young man

PROJECT_TITLE: Dystrophin Replacement

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative Aging is the biggest risk factor for Alzheimer's disease (AD) and related dementias (ADRD). In this application we present data showing ATP synthase to link aging and ADRDs at the molecular level and propose a model on how it extends lifespan and restores memory in aged symptomatic mouse models of ADRD through GeroNeuroProtection. We show ATP synthase to be druggable and how the concept of geroneuroprotection can be expanded to test other geroproprotector drugs identified by the intervention testing program (ITP) for their ability to protect neurons from age-associated toxicities in ADRDs.

PI_NAMEs: PETRASCHECK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acarbose;Acceleration;Acetyl Coenzyme A;Acetylation;Address;age related;age related deterioration;age-related disease;aged;Aging;aging mechanism;aging related;alpha ketoglutarate;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;animal old age;Animals;ATP Synthesis Pathway;Behavioral Assay;Biological Assay;Brain;Brain Pathology;Caenorhabditis elegans;Cell Culture Techniques;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Cognitive deficits;cognitive function;Complex;Data;Dementia;Dendritic Spines;Deterioration;Disease;drug candidate;Drug Targeting;Electrophysiology (science);Energy Metabolism;Epigenetic Process;Estradiol;extend lifespan;F1F0-ATP synthase;fly;functional decline;Gene Expression;Genes;Genetic Transcription;geroprotector;Geroscience;Glycolysis;Goals;Histone Acetylation;Homeostasis;Human;illness length;Impairment;improved;Individual;insight;Intervention;Lead;Link;Long-Term Potentiation;Memory;Memory Loss;Metabolism;Mitochondria;Mitochondrial Proton-Translocating ATPases;Modeling;Molecular;mouse model;Mus;Neurons;neuropathology;neuroprotection;Onset of illness;Oxidative Stress;Pathologic;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;preservation;prevent;Process;Production;programs;promoter;protective effect;proteotoxicity;Publishing;rational design;response;RNA Interference;Rodent Model;Role;Sirolimus;Slice;Stress;Synapses;synaptic function;Synaptosomes;synergism;tau Proteins;Testing;Therapeutic;Toxic effect;Wild Type Mouse;Work

PROJECT_TITLE: Lowering Mitochondrial ATP Synthase Activity Slows Aging and Alzheimer's Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Cystic Fibrosis;Kidney Disease;Lung;Orphan Drug;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Adult autosomal dominant polycystic kidney disease is a genetic disease which causes a progressive enlargement of multiple renal cysts, leading to renal failure in 50% of patients. The goal is to develop a therapy based on reducing cyst growth.

PI_NAMEs: CEBOTARU, LIUDMILA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;Address;Adult;Affect;Apical;Automobile Driving;Autosomal Dominant Polycystic Kidney;autosome;Back;Blood Vessels;Cell membrane;Clinical;Cyclic AMP;Cyst;Cyst Fluid;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cystic kidney;Data;design;Development;Disease;Disease Progression;Drug Design;Drug Targeting;Duct (organ) structure;Ductal Epithelial Cell;epithelial Na+ channel;Epithelium;fluid flow;Fluids and Secretions;Foundations;Genes;Genetic Diseases;Goals;Growth;Health Care Costs;Healthcare;healthcare burden;Heart;Human;human disease;improved;Inherited;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Length;Liquid substance;Liver;liver function;Location;Measures;Membrane;Methodology;Modeling;Morbidity - disease rate;mortality;mouse model;Mutation;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Pancreas;Patients;Persons;Pharmaceutical Preparations;Phenotype;Proprotein Convertase 1;Proprotein Convertase 2;Proteins;receptor;Renal function;response;Role;side effect;symptom treatment;System;Testing;Therapeutic;Therapeutic Uses;tolvaptan;trafficking;Treatment Protocols;treatment strategy;Ubiquitination;Vasopressins;VX-770;VX-809;Work

PROJECT_TITLE: Developing a New Therapeutic Approach for Autosomal Dominant Polycystic Kidney Disease.

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: NARRATIVE Most of our clinically used antibiotics are derived from a group of small molecules produced by bacteria. We have recently learned that bacteria harbor a much larger potential for the biosynthesis of antibiotic-like molecules, though our understanding of how the corresponding biosynthetic pathways are regulated and how they can be activated is in its infancy. Our research aims to elucidate the mechanisms that lead to the biosynthesis of such molecules, and to use these insights to discover new compounds with possibly therapeutic properties.

PI_NAMEs: SEYEDSAYAMDOST, MOHAMMAD R (contact)

PROJECT_TERMS: Actinobacteria class;Address;Anabolism;Antibiotics;Bacteria;bacterial metabolism;Bacterial natural products;beta-Lactams;Biochemistry;Bioinformatics;Biological;biological adaptation to stress;Biology;Burkholderia;Cefotaxime;Ceftazidime;Cells;Chemicals;Chemistry;Clinical;Collection;Coupled;Detection;Dimensions;Dose;experimental study;Gene Cluster;Genes;genome sequencing;Goals;Growth;infancy;innovation;insight;Investigation;Laboratories;Learning;Link;mass spectrometric imaging;Measures;Metabolism;metabolome;Methodology;Methods;microbial;Microbial Physiology;model organism;Myxococcales;Natural Products;novel;Organism;Pathway interactions;pharmacologic;Pharmacology;Play;programs;Property;Reactive Oxygen Species;Regulation;Regulatory Pathway;Research;response;Role;Scheme;screening;secondary metabolite;small molecule;small molecule libraries;Source;Therapeutic;Therapeutic Agents;Time;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Exploring a New Dimension of Microbial Secondary Metabolism

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Given the lack of data on the relationships between prenatal exposures and stressors with postpartum maternal health, the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) Center will focus on two maternal health outcomes of utmost concern: maternal depression and cardiovascular health in the years after childbirth. The MADRES Center will examine whether prenatal environmental exposures and social stressors lead to higher depression and/or cardiovascular risk factors postpartum and whether patterns in exposure disparities from the built environment and physical, chemical or social stressors at the residential and neighborhood level relate to individual-level characteristics including allostatic load.

PI_NAMEs: BASTAIN, THERESA M;BRETON, CARRIE VAN DOREN (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Acculturation;Address;Affect;African American population;Air Pollution;allostatic load;Attention;Awareness;Behavior;built environment;burden of illness;California;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Chemicals;Childbirth;Clinical;cohort;community building;community engagement;Country;Data;Development;disorder prevention;disparity elimination;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;Environmental Impact;Environmental Risk Factor;environmental stressor;ethnic disparity;experience;Exposure disparity;Exposure to;Functional disorder;Health;health care service;Health Disparities Research;health disparity;health disparity populations;Hispanic Americans;Hispanic Women;Hypertension;Immigrant;Individual;Inequity;Inflammatory;innovation;interdisciplinary approach;Intervention;Knowledge;knowledge base;Language;late life;Lead;Low income;maternal depression;Maternal Health;maternal morbidity;Mediating;men;Mental Depression;Mental Health;Mental Health Services;Mentorship;Minority;Morbidity - disease rate;mortality;multidisciplinary;Neighborhoods;Neurosecretory Systems;next generation;Not Hispanic or Latino;Outcome;Pathway interactions;Pattern;Persons;Policies;Population;Positioning Attribute;postpartum health;Postpartum Period;Pre-Eclampsia;Predisposition;preference;Pregnancy;Pregnancy Complications;prenatal;prenatal environmental exposure;prenatal exposure;Prevalence;Prevention;prevention practice;Prevention strategy;programs;Psychiatry;Psychosocial Stress;Public Health;racial disparity;Recommendation;Research;Research Personnel;Research Project Grants;Residential Mobility;Risk;Risk Factors;Science;Scientist;social;social stressor;Spanish;Stress;stressor;Woman;Women's prevalence

PROJECT_TITLE: Maternal and Developmental Risks from Environmental and Social Stressors (MADRES)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: BRETON, CARRIE VAN DOREN (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Budgets;California;cardiovascular risk factor;Clinical;Communities;community engagement;Development;disparities in women;Educational workshop;Ensure;Environment;Environmental Health;environmental health disparity;Environmental Risk Factor;environmental stressor;Equity;Evaluation;Expenditure;Faculty;Fostering;Goals;Grant;Health;Health Disparities Research;health disparity;health disparity populations;health literacy;Infrastructure;Institution;interest;Internships;Joints;Leadership;meetings;Mental Health;Monitor;multidisciplinary;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;next generation;Peer Review Grants;Pilot Projects;Policy Maker;Postdoctoral Fellow;Postpartum Period;program dissemination;programs;Public Health;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Scientist;skills;social;social media;social stressor;student mentoring;synergism;timeline;training opportunity;Translating;Translations;undergraduate student;Universities;web site;Writing

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Disease of the blood vessels in the brain, known as cerebral small vessel disease (cSVD), is an important modifiable risk factor for decline of mental abilities and dementia. This novel, longitudinal experimental design will use neuroimaging in cognitively normal older adults to study enlarged perivascular spaces, a poorly defined biomarker of cSVD. Clinically informative biomarkers could identify people most at risk for developing cSVD-related cognitive dysfunction and point to avenues of therapeutic improvements for patients with cerebrovascular disease.

PI_NAMEs: LIBECAP, TJ  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Basal Ganglia;Biological Markers;biomarker development;Blinded;Blood - brain barrier anatomy;blood oxygen level dependent;Blood Vessels;Brain;Brain region;burden of illness;career;Cerebral small vessel disease;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Disorders;cerebrovascular reactivity;Characteristics;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Consensus;constriction;Data;Data Analyses;Dementia;demographics;Development;Disease;early detection biomarkers;Early Diagnosis;environmental change;Excision;executive function;experience;Experimental Designs;experimental study;Fellowship;Flushing;follow-up;Foundations;Functional Magnetic Resonance Imaging;Gases;Gold;Growth;Guidelines;Head;Hematological Disease;Hippocampus;Image;imaging facilities;Impaired cognition;improved;in vivo;indexing;innovation;Intercellular Fluid;interest;Kentucky;Knowledge;Laboratories;Lesion;Liquid substance;longitudinal design;Magnetic Resonance;Magnetic Resonance Imaging;Manuals;Maps;Measures;Mentors;Methods;Microvascular Dysfunction;Midbrain structure;modifiable risk;MRI Scans;Nerve Degeneration;neuroimaging;neuroimaging marker;Neuropsychological Tests;Neurosciences;neurovascular coupling;novel;older adult;Participant;Patients;Persons;pre-doctoral;predictive marker;Predisposition;prisma;Protocols documentation;Psyche structure;Regression Analysis;response;Risk;Risk Factors;Scanning;Scientist;Screening procedure;Site;Slice;solute;Standardization;Techniques;Testing;Therapeutic;Time;tool;Training;Universities;vascular cognitive impairment and dementia;wasting;white matter;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Investigating Enlarged Perivascular Spaces as a Neuroimaging Biomarker of Cerebral Small Vessel Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hematology;Hepatitis;Hepatitis - C;Hypertension;Infectious Diseases;Kidney Disease;Liver Disease;Prevention;Rare Diseases;Sickle Cell Disease;Tuberculosis;Vector-Borne Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE: Data from our ongoing Renal Risk Reduction (R3) study in Nigeria has shown that ~37% of our HIV-positive, ART-treated adults have microalbuminuria. We aim to perform more in-depth testing among cohorts of HIV- positive and HIV-negative adults to determine what factors (including hypertension, co-infection with certain viral, parasitic, and bacterial infections that lead to immune activation, and exposure to potentially nephrotoxic ARV medications) contribute most to microalbuminuria in our population. Findings from this study will support the development of interventions to address microalbuminuria in PLWH to reduce kidney and cardiovascular morbidity and mortality.

PI_NAMEs: ALIYU, MUKTAR HASSAN;MUSA, BABA MAIYAKI;WESTER, C. WILLIAM  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Age;Albumins;Albuminuria;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;antiretroviral therapy;APOL1 gene;Bacterial Infections;Biological Markers;Blood Pressure;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;CD14 gene;CD4 Lymphocyte Count;Cells;cigarette smoking;co-infection;cohort;comorbidity;Creatinine;Cytomegalovirus;Data;Development;Diabetes Mellitus;Disease;Early Diagnosis;eligible participant;Endothelium;Enrollment;Etiology;experience;Exposure to;Fibrin fragment D;Filaria bancrofti;Fumarates;General Population;Hepatitis B;Hepatitis C;Hepatitis C co-infection;High Prevalence;high risk;HIV;HIV Seronegativity;HIV Seropositivity;Hypertension;immune activation;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;Kidney;Kidney Diseases;Lisinopril;Loa loa;Low Prevalence;macroalbuminuria;Measurement;Medical;Microalbuminuria;Monitor;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;nephrotoxicity;Nigeria;non-diabetic;normotensive;Onchocerca volvulus;Organ;Parasitic infection;Participant;Persons;Pharmaceutical Preparations;Phase;Plasmodium falciparum;Population;prehypertension;Prevalence;prospective;randomized placebo controlled trial;Regimen;Renin-Angiotensin-Aldosterone System;Risk;Risk Factors;Risk Reduction;risk variant;Role;Schistosoma;screening;sex;Sickle Cell Trait;Site;Smoking;Specimen;Strongyloides stercoralis;T-Cell Activation;Teaching Hospitals;Tenofovir;Testing;therapy development;TNFR-Fc fusion protein;TNFRSF1A gene;Tuberculosis;vascular endothelial dysfunction;Viral;Virus Diseases

PROJECT_TITLE: Etiology of Persistent Microalbuminuria in Nigeria

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Applications Grants;Area;Award;California;career;career development;Collaborations;Communities;community engagement;design;Development;Diverse Workforce;Doctor of Philosophy;Education;Educational Status;Enrollment;Ensure;Environmental Epidemiology;Environmental Health;environmental health disparity;Environmental Risk Factor;environmental stressor;Epidemiology;Face;Feedback;Fostering;Funding;Goals;graduate student;Grant;Health Disparities Research;health disparity populations;higher education;improved;Interdisciplinary Study;Internships;Lead;matriculation;Mentors;Mentorship;Mission;multidisciplinary;next generation;Pilot Projects;Postdoctoral Fellow;Preventive measure;Process;professor;programs;Public Health;Publications;Reporting;Research;Research Personnel;Running;Scientist;social stressor;Students;success;Training;Transcend;undergraduate education;undergraduate student;Universities;Work

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Genetics

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Narrative: Circadian clocks regulate daily rhythms in mRNA levels and protein production to control cell physiology, and defects in the clock are associated with sleep disorders, metabolic syndrome, cancer, and heart disease. As a consequence of clock regulation of protein levels and metabolism, many drugs are more effective or more toxic depending on the time of administration. We will investigate a new and unexplored way that the circadian clock regulates the levels and accuracy of protein synthesis, which may provide insights into new approaches to treat clock-associated diseases and improve the timing of drug treatments.

PI_NAMEs: BELL-PEDERSEN, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Amino Acids;Amino Acyl-tRNA Synthetases;Binding;Cell Physiology;Cells;Cellular Metabolic Process;Charge;circadian pacemaker;circadian regulation;Circadian Rhythms;Defect;Disease;drug metabolism;EIF-2alpha;Eukaryota;Genome;Health;Heart Diseases;Human;improved;insight;Malignant Neoplasms;Messenger RNA;Metabolic syndrome;Metabolism;Methionine;Methionine-tRNA Ligase;Modeling;Molecular Chaperones;mRNA Translation;Neurospora crassa;novel strategies;Periodicity;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Phosphotransferases;Probability;Production;Protein Biosynthesis;protein folding;Proteins;Proteome;Regulation;Regulatory Pathway;Ribosomal Proteins;Ribosomes;Sleep Disorders;Terminator Codon;Testing;Time;Transfer RNA;Transfer RNA Aminoacylation;Translating;Translation Initiation;Translations;Work

PROJECT_TITLE: Mechanisms of Circadian Clock Control of mRNA Translation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: JOHNSTON, JILL E (contact)

PROJECT_TERMS: Address;Air;air monitoring;Air Pollution;Award;Awareness;Back;bilingualism;built environment;cardiometabolism;Characteristics;Chemicals;Clinical;cohort;Collaborations;Communication;Communication Methods;Communities;community based participatory research;community engagement;Community Health Aides;community setting;Decision Making;design;Development;Educational Materials;Educational workshop;empowerment;Environment;Environmental Health;environmental health disparity;Environmental Risk Factor;environmental stressor;Equity;Evaluation;Fostering;Health;health care service organization;health disparity populations;health literacy;Health Personnel;Healthcare;Household;Individual;innovation;Internships;Justice;land use;Language;Latina Population;leadership development;Learning;literacy;Logic;Los Angeles;Mental Health;Methods;Mission;Modeling;Mothers;multi-ethnic;Multilingualism;Neighborhoods;novel;Online Systems;Outcome;Participant;Pattern;Persons;Pilot Projects;Poison;Policies;Policy Maker;postpartum health;Postpartum Period;Postpartum Women;Pregnancy;Printing;Process;programs;Public Health;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Resources;Risk;Role;Science;Scientist;Series;social;Social Justice;social media;social stressor;Stress;stressor;Structure;Students;success;Techniques;tool;Training;training opportunity;Update;urban health disparities;Vulnerable Populations;women of color;Women's Health;Youth

PROJECT_TITLE: Community Engagement and Dissemination Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

PI_NAMEs: BASTAIN, THERESA M (contact)

PROJECT_TERMS: Acculturation;Adolescence;Affect;Air Pollutants;Air Pollution;ambient air pollution;Animals;Awareness;Biological;Brain;Cell Physiology;Chronic stress;cohort;coping;Country;critical period;cytokine;depressive symptoms;design;Development;disadvantaged women;Disease;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epigenetic Process;Epinephrine;Exposure to;Fetal Development;fine particles;Functional disorder;Gene Expression;Gene Targeting;Genetic Predisposition to Disease;health care service;health disparity populations;Hispanic;Hispanic Women;Hormonal;Hormones;Human;Hydrocortisone;improved;Individual;Inflammatory;inflammatory marker;Interleukin-6;Language;Los Angeles;Major Depressive Disorder;maternal depression;maternal risk;Mediating;Mediator;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;MicroRNAs;middle age;modifiable risk;Morbidity - disease rate;neighborhood disadvantage;neuroinflammation;Neurosecretory Systems;Norepinephrine;Not Hispanic or Latino;Pathway interactions;perceived stress;Persons;Policies;Population;Postpartum Depression;Postpartum Period;Predisposition;preference;Pregnancy;prenatal;prenatal exposure;psychosocial;psychosocial stressors;public health priorities;Recording of previous events;Recurrence;Regulator Genes;Reproductive Periods;response;Risk;Risk Factors;Role;social;social disparities;Social status;social stressor;socioeconomic disadvantage;Stress;Stressful Event;Subgroup;Symptoms;Testing;Victimization;Woman;Women's prevalence

PROJECT_TITLE: Project 1: Maternal Prenatal Exposure to Environmental and Psychosocial Stressors and Long-term Risk of Depression


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Traumatic stress exposure is a major risk factor for physiological and psychiatric diseases with avoidant behavior as a common indication. The bed nucleus of the stria terminalis (BNST) projects to important regions in the hypothalamus involved in stress regulation, but it is not understood how the functionality of these discrete circuits become hyperactive during stress and promote avoidance over approach in future stressful situations. This proposal will investigate the role of the GABA and glutamate BNST to the hypothalamus projections as a mechanism for stress-induced avoidance, thereby elaborating on the involvement of specific cell-types and circuits in stress psychopathologies.

PI_NAMEs: LY, ANNIE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Amygdaloid structure;Anterior;Anxiety;Appetitive Behavior;approach behavior;Aversive Stimulus;avoidance behavior;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain region;cell type;Cells;Clinical;Corticosterone;Data;Development;Eating;Electrophysiology (science);Energy Metabolism;Environment;Exhibits;experience;Experimental Designs;feeding;Food;FOS gene;Foundations;Future;gamma-Aminobutyric Acid;Genetic;genetic profiling;glutamatergic signaling;Glutamates;Goals;Homeostasis;Human;Hunger;Hyperactivity;Hypothalamic structure;In Situ Hybridization;Lesion;Light;Mental disorders;Messenger RNA;Metabolic;mouse model;Mus;neural;Neurobiology;Neurons;Neurosecretory Systems;neurotransmitter release;Neurotransmitters;novel;Opsin;optogenetics;Organism;Output;Panic Disorder;paraventricular nucleus;patch clamp;Pathway interactions;Physiological;Physiological Adaptation;Plasma;Post-Traumatic Stress Disorders;Property;Psychopathology;recombinase;Regulation;response;restraint stress;Risk Assessment;Risk Factors;Role;Site;Stress;Stressful Event;stressor;Structure of nucleus infundibularis hypothalami;Structure of terminal stria nuclei of preoptic region;Synapses;Training;transmission process;traumatic stress;vector;Viral;Whole-Cell Recordings

PROJECT_TITLE: BNST circuitry to hypothalamic regions in stress-induced avoidance