NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Oral cancer represents a significant societal burden. In this project, we propose to identify the key underlying causes of oral cancer by investigating changes in the chromatin environment brought about by an enzyme, lysine-specific demethylase 1 (LSD1). We anticipate that this study will increase knowledge about the biology of oral cancer, explore a synergistic combination of effective therapy, and lead to the development of novel treatment strategies for this pernicious disease.

PI_NAMEs: BAIS, MANISH  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Animal Model;anti-cancer research;anti-PD-1;anti-PD-L1 antibodies;anti-PD1 therapy;Attenuated;attenuation;Biology;Breast;cancer stem cell;carcinogenesis;Carcinoma in Situ;cell type;Cells;Cessation of life;Chromatin;Clinical;clinically relevant;Collaborations;connective tissue growth factor;Data;design;Development;Disease;Dysplasia;effective therapy;Environment;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;epigenome;Epithelium;experience;Family Felidae;Future;Genetic;Goals;high risk;histone demethylase;Human;IL-6 inhibitor;IL6 gene;Immune;immune checkpoint;Immunotherapy;in vivo;inhibitor;Interleukin-6;JAK2 gene;KDM1A gene;Keratin;Knockout Mice;Knowledge;Lead;Lesion;Leukoplakia;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;malignant phenotype;Medicine;Modification;mouse model;mouth squamous cell carcinoma;Mus;Neoplasms;Nivolumab;Normal tissue morphology;novel;Nuclear;Oral;Oral cavity;oral tissue;Pathologic;Pathway interactions;patient derived xenograft model;Patients;PD-1 inhibitors;pharmacologic;Phenotype;Positioning Attribute;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;Proteomics;Publishing;Recurrence;Resistance;Role;Sampling;Signal Induction;Signal Transduction;single-cell RNA sequencing;STAT3 gene;stem;stem cells;Testing;Therapeutic;Therapeutic Studies;therapy resistant;Time;Tissue Sample;Tongue;Topical application;translational study;Translations;treatment strategy;tumor;tumor progression;United States;Up-Regulation;Work

PROJECT_TITLE: Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Protein quality control (PQC) is the balance of protein folding and degradation that is regulated by molecular chaperones and the 26S proteasome. Proper PQC is essential for human health, and an imbalance leads to disease, including cancer or neurodegeneration. This proposal seeks to understand the molecular mechanisms underlying how chaperones can directly target substrates to the proteasome for degradation.

PI_NAMEs: GATES, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Affect;ATP Hydrolysis;ATP phosphohydrolase;BCL2 gene;bcr-abl Fusion Proteins;Binding;Complex;Cryoelectron Microscopy;Data;Degradation Pathway;Disease;Equilibrium;experience;experimental study;Goals;Guanine Nucleotide Exchange Factors;Health;Heat Shock 70kD Protein Binding Protein;Human;human disease;Huntington gene;In Vitro;insight;interdisciplinary approach;Malignant Neoplasms;Mediating;Molecular;Molecular Chaperones;Molecular Conformation;multicatalytic endopeptidase complex;mutant;Nerve Degeneration;novel strategies;Nucleotides;Pathway interactions;Positioning Attribute;post-doctoral training;Process;programs;protein degradation;protein folding;Proteins;Quality Control;Reporting;Research;single-molecule FRET;Structure;Techniques;Triage;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Mechanisms of chaperone-mediated proteasomal degreadation

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Gene expression relies on RNA regulation to orchestrate where and when a distinct transcript is translated to alter cell fate. These processes allow for dynamic responses to internal and environmental cues that can depict even where along an RNA translation initiation begins during the final stage of gene expression, enhancing genetic diversity through non-conventional protein synthesis. This proposal seeks to map the complete proteome during cellular growth and adaptation, while uncovering the regulatory mechanisms of RNA epigenetics in these processes, with opportunity for improved diagnostics and innovative RNA therapeutics in disease states.

PI_NAMEs: CONN, CRYSTAL S (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Area;Binding Proteins;cancer cell;cell growth;Cell Survival;Cells;Chromosomal Rearrangement;Chromosome Mapping;clinical biomarkers;Cues;design;Diagnostic;diagnostic biomarker;Disease;Disease Progression;Epigenetic Process;Foundations;Gene Expression;Genetic;Genetic Enhancement;Genetic Variation;genome annotation;genome-wide analysis;Growth;improved;innovation;Innovative Therapy;insight;interdisciplinary approach;Maintenance;malignant phenotype;Maps;Modeling;Modification;mRNA Translation;novel therapeutics;Oncogenic;Patients;Peptides;Phenotype;Post-Transcriptional Regulation;posttranscriptional;Process;prognostic;programs;Protein Biosynthesis;Proteins;Proteome;Proteomics;Regulation;Research;response;Ribosomes;RNA;Sampling;Signal Transduction;Site;therapeutic RNA;Transcript;Transcriptional Regulation;Translating;Translation Initiation;Translational Regulation;Translations;tumor progression;Variant

PROJECT_TITLE: Dynamics of RNA regulation and noncanonical translation between cell states

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Break-induced replication (BIR) is a unique DNA repair mechanism associated with telomerase- independent telomere maintenance and genome instability. In this MIRA R35 proposal, we will elucidate the mechanisms that promote BIR in the genome and at telomeres to better understand the relationship between transcription and genome instability.

PI_NAMEs: MIN, JAEWON  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Attention;Bacteriophages;Biochemistry;Cell Survival;Cellular biology;Cellular Metabolic Process;Coupled;DNA biosynthesis;DNA Double Strand Break;DNA Repair;Endogenous Factors;Exogenous Factors;Genetic;Genetic Transcription;Genome;Genomic Instability;Genomics;Goals;interdisciplinary approach;Length;Mammalian Cell;Mammals;Normal Cell;Process;repaired;Role;Techniques;Telomerase;telomere;Telomere Maintenance;tool

PROJECT_TITLE: Mechanisms and Genetic Consequences of Break-Induced Replication.

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: TALLAHASSEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Cells in the human body use actin bound force sensitive proteins to sense directionality of external forces and drive development, maintenance, and remodeling of tissues. These studies will provide quantitative microscopy methods and materials systems for a new approach to simultaneously analyze actin orientation, actin velocity, and forces in these complexes. The themes outlined here will form the basis for a research program that is focused on identifying and manipulating the molecular basis of directional mechanosensing, in order to prevent or reverse disease processes that involve mechanosensing driven tissue remodeling (fibrosis and degeneration) or aberrant cellular migration (developmental diseases and cancers).

PI_NAMEs: DRISCOLL, TRISTAN P (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Quantitative Molecular Imaging in Engineered Cellular Microenvironments to Study and Control Directional Mechanosensing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE There is a critical need to identify modifiable factors and effective strategies throughout the life course that can promote cognitive function, delay cognitive decline, and mitigate Alzheimer's Disease and Related Dementias (ADRD) risk in diverse populations across sociocultural and economic contexts. This project will use cross- nationally harmonized data to investigate the impact of labor force participation and key stimulating activities in middle and later life on cognitive aging outcomes by gender and across sociocultural contexts. Findings from this study will provide critical insights to inform global prevention of ADRD—especially in low- and middle- income countries' populations that are growing rapidly and are most vulnerable to the challenges posed by ADRD—by informing tailored interventions and policies in the US and globally to improve population health.

PI_NAMEs: ZHANG, YUAN S (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Aging;aging mind;aging population;aging process;Agriculture;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;care costs;Caring;Childhood;China;Cognitive;Cognitive aging;cognitive function;cognitive testing;Communities;contextual factors;Country;Data;data harmonization;Dementia;dementia risk;Developed Countries;Economics;Education;emerging adult;England;Ethnic Origin;experience;Gender;gender difference;Impaired cognition;improved;Income;India;Individual;insight;International;Intervention;labor force participation;Labor Forces;late life;Life;Life Cycle Stages;low and middle-income countries;manufacture;Marketing;men;Mexico;Neuropsychology;novel;Occupations;older adult;Older Population;older women;Outcome;Parents;Participant;Persons;Policies;Population;population health;Population Heterogeneity;prevent;Prevention;Protocols documentation;Quality of life;Race;Research;Resources;response;Role;Sampling;Shapes;social;social culture;Source;Woman;Work

PROJECT_TITLE: Engaging Aging Minds: Labor Force Participation, Stimulating Activities, and Cognitive Aging Across Diverse International Settings.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Alzheimer's disease is associated with pathophysiological processes many years prior to clinical symptom onset, characterized by the accumulation of beta-amyloid plaques. Beta-amyloid burden serves as a critical biomarker for identifying individuals at high risk of clinical progression and for evaluating treatment efficacy. In this project, we aim to develop a novel, non-invasive MRI method that is sensitive to beta-amyloid, with the goal of supplementing or potentially replacing amyloid PET.

PI_NAMEs: XU, XIANG  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Acceleration;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloidosis;Anatomy;Animals;Applications Grants;Area;attenuation;Biological Markers;Brain;Brain imaging;Brain region;Chemicals;Clinical;clinical risk;comparative;Complex;cost;Data;design;Detection;detection method;Disease Progression;effectiveness evaluation;Exhibits;Foundations;Frequencies;Generations;Goals;Head;healthy volunteer;high resolution imaging;high risk;Human;Image;image reconstruction;Imaging Techniques;improved;in vivo;Individual;innovation;Laboratories;Length;Liver Glycogen;liver imaging;Magnetic Resonance Imaging;Maps;Measurement;Mediating;Methods;Monitor;Morphologic artifacts;Motion;Mouse Protein;Nature;Nerve Degeneration;novel;Nuclear;older adult;Older Population;parent project;Parents;Pathologic;Pathologic Processes;Phase;Physiologic pulse;Positron-Emission Tomography;pre-clinical;Predisposition;Process;Property;protein aggregation;Proteins;Protocols documentation;Protons;Radial;Radioactive;radiotracer;Research;resilience;Resolution;response;Scanning;Scheme;Senile Plaques;Shapes;Signal Transduction;Speed;Standardization;Symptoms;Techniques;Testing;Time;Tissues;Tracer;Treatment Efficacy;Treatment outcome;uptake;Water;β-amyloid burden

PROJECT_TITLE: In vivo measurement of Amyloid in preclinical Alzheimer's Disease by saturation transfer MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders

ORG_CITY: Los Angeles

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Dense core secretory granules are organelles for the intracellular storage of peptide hormones and stimulus- dependent exocytosis in regulated secretory cells. Defects in maturation and secretion of secretory granules can lead to several mental and metabolic disorders, but the causes of these disorders are poorly understood and there is a critical need for more effective therapeutics. We seek to understand how different cellular signals effect granule maturation and secretory efficiency to identify targets for future design of improved therapeutics.

PI_NAMEs: WHITE, KATE L. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Beta Cell;Bipolar Disorder;Black Box;cell type;Cells;Cellular biology;Clathrin;Complement;Cyclic AMP;Cytoplasmic Granules;Defect;design;Development;Diabetes Mellitus;Disease;Drug Targeting;Exocytosis;fluorescence lifetime imaging;Future;Goals;Hormones;imaging approach;improved;insight;Interphase Cell;Knowledge;Lead;Lipids;live cell imaging;Location;Maps;Mental Depression;Mental disorders;Metabolic Diseases;Mitochondria;Molecular;Monitor;Neurons;Organelles;peptide hormone;Peptides;Pro-Opiomelanocortin;Proinsulin;Proteins;Secretory Cell;Secretory Vesicles;Signal Pathway;Signal Transduction;Stains;Stimulus;Therapeutic;therapeutically effective;Work;X-Ray Tomography

PROJECT_TITLE: A generalizable platform to identify cellular mechanisms that enhance secretory efficiency

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Little is known about the changes in single-cell level protein composition in the brain during Alzheimer’s disease (AD) progression. This project will use a novel Gel-based Optical-isolation 3D (GO3D) single-cell-type multiomics to spatially profile proteins, RNAs, and chromatin accessibility of an AD-associated cell type, astrocyte. The outcomes of this project will unbiasedly provide a list of AD-associated proteins and PTMs, which can be new potential targets for AD treatment.

PI_NAMEs: SHI, XIAOYU  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Amyloid beta-Protein;Astrocytes;Award;blind;Brain;brain cell;Brain Mass;brain tissue;candidate identification;Cell Nucleus;Cell Physiology;Cell Separation;cell type;Cells;Chromatin;Cicatrix;Dendrites;Development;Disease;Disease Progression;DNA;Endothelial Cells;Epigenetic Process;excitatory neuron;Foundations;Gel;Genetic Fingerprintings;Genetic Transcription;Genome;Goals;Human;inhibitory neuron;Magic;Maps;Mass Spectrum Analysis;Measures;Mechanics;Memory Loss;Methods;Microglia;Microscopic;Molecular;mouse model;multiple omics;Mus;neural;Neurologist;Neurons;new technology;next generation sequencing;novel;Nucleic Acids;oligodendrocyte progenitor;Oligodendroglia;Optics;Outcome;Pathogenicity;Pathologic;Phenotype;Post-Translational Protein Processing;precursor cell;Prefrontal Cortex;protein profiling;Proteins;Proteome;Proteomics;Protocols documentation;Regulatory Element;Research;Research Personnel;RNA;Science;Senile Plaques;single cell analysis;single cell sequencing;single-cell RNA sequencing;Structure;Synapses;Techniques;Technology;therapeutic target;Time;Tissues;transcriptome;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: 3D spatial single-cell multiomics mapping of Alzheimer's disease


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: GENETICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The blood-brain and blood-retinal barriers play a crucial role in regulating the transportation of essential nutrients, waste products, and harmful pathogens between the bloodstream and the brain and eye. In-depth research on the molecular mechanisms governing the formation and maintenance of these barriers serves as the cornerstone for developing effective therapeutic approaches to address vascular defects in the brain and retina. The outcome of this project will demonstrate the mechanisms of retinal and CNS angiogenesis and pave the way for groundbreaking advancements in treating various conditions affecting the brain and retina.

PI_NAMEs: LI, XIAOCHUN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adult;Affect;angiogenesis;Back;Binding;Binding Sites;Biochemical;Biological Assay;biophysical techniques;Biophysics;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood Vessels;blood-brain barrier function;Blood-Retinal Barrier;Brain;Cells;Central Nervous System;central nervous system vasculature;Cerebellum;Cholesterol;Collaborations;Complex;Cysteine-Rich Domain;Data;Defect;Development;Disease;Ear;Ensure;Event;Eye;Family;Frizzled Domain;Genes;Goals;Homeostasis;human disease;Hydrophobic Interactions;In Vitro;Inherited;innovation;insight;Investigation;Knock-out;Knowledge;LDL-Receptor Related Proteins;Lead;Ligands;Light;Link;Low Density Lipoprotein Receptor;Maintenance;Mediating;member;Methods;Molecular;Molecular Mechanisms of Action;Molecular Structure;morphogens;Mus;Mutation;N-terminal;Neural Retina;Neural tube;neurological pathology;Norrie's disease;novel therapeutic intervention;Nutrient;Outcome;pathogen;Pathway interactions;Play;Process;protein complex;protein reconstitution;Proteins;receptor;Recombinants;Reporting;Research;Resolution;restoration;Retina;retinal angiogenesis;Retinal Diseases;Role;Signal Transduction;Signaling Molecule;Solubility;Specificity;Structure;Testing;Therapeutic Intervention;therapeutically effective;Tissues;Transportation;vascular abnormality;Vascular System;Vascularization;Vision;Waste Products;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanisms of Wnt ligand specific signaling in the development of blood-retina barrier and blood-brain barrier

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative Neuroactive steroids (NASs) are synthesized in the brain from progesterone and play a central role in regulating neuronal excitability and behavior. Here we will test the role that a novel family of G-protein receptors for NAS play in mediating the their sustained effects on neuronal excitability. The results of this studies will provide new information on NAS signaling which may ultimately lead to new strategies to improve mental health.

PI_NAMEs: MOSS, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Ablation;Acute;Allopregnanolone;Anti-Anxiety Agents;anti-depressive agents;Anticonvulsants;Behavior;Binding;Brain;Cell Line;Cell membrane;Cell Survival;Cells;Chronic;Couples;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;dentate gyrus;Development;Exposure to;Family;Fishes;G-Protein-Coupled Receptors;Genes;GTP-Binding Proteins;Hippocampus;hypnotic;improved;Individual;insight;Mammalian Cell;Mediating;member;Membrane;Mental Health;Modification;Mus;Neuroglia;neuronal excitability;neuronal survival;Neurons;neurosteroids;novel;pharmacologic;Phase;Phosphorylation;Plasma;Play;pleiotropism;positive allosteric modulator;Postpartum Depression;Process;Progesterone;Progesterone Receptors;Property;protein activation;Protein Isoforms;Protein Kinase;Protein Kinase C;receptor;Receptor Signaling;reproductive;Role;Signal Transduction;Slice;Specificity;Steroid Receptors;Structure;Synapses;Testing;Tissues;tool;trafficking;Tubulin;Yeasts

PROJECT_TITLE: Studies on G-protein coupled receptors that are activated by neuroactive steroids

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Sepsis

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Artificial intelligence (AI) and machine learning (ML) methods offer a promising approach to improve the timely recognition and management of patients with and at risk for sepsis. However, several important clinical and analytic questions about the development of sepsis-focused AI/ML clinical decision support systems remain unanswered, thereby limiting the development of useful clinical decision support systems. Therefore, this pro- posal will explore several foundational questions in sepsis care to develop AI/ML systems that are timely, useful at the bedside, and scale across diverse clinical contexts.

PI_NAMEs: WEISSMAN, GARY  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accident and Emergency department;Active Learning;Affect;antimicrobial;Artificial Intelligence;autoencoder;care outcomes;Caring;Cause of Death;Clinical;clinical care;clinical decision support;Clinical Decision Support Systems;clinical effect;clinical trial enrollment;Communities;Complex;convolutional neural network;cost;Data;denoising;design;Development;Environment;Epidemiologic Monitoring;Face;Functional disorder;Hospitalization;Hospitals;Immune response;improved;Infection;Informatics;Intensive Care Units;Knowledge;Label;Learning;Machine Learning;machine learning method;Methods;Organ;Outcome;Paper;patient population;Patient-Focused Outcomes;Patients;Pattern;Process;Publishing;Quality of life;Risk;Sepsis;Standardization;Syndrome;System;Time;Training;treatment effect;Uncertainty;ward

PROJECT_TITLE: Improving sepsis care with AI-based clinical decision support

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE In this administrative supplement application, we will construct a computable ADRD knowledge hub (ADKH) from Pubmed literature to accelerate ADRD knowledge discovery, and evaluate several longitudinal deep learning architectures for real-time ADRD risk assessment with electronic health record (EHR) incorporating knowledge from ADKH. This research will meet a pressing and unresolved need to conduct ADRD predictive modeling leveraging knowledge from literature. This supplement project aims to deliver novel informatics methods for graph embedding and build gated recurrent unit with decay (GRU- D) based models for dynamic ADRD risk assessment.

PI_NAMEs: LIU, HONGFANG  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Acceleration;Administrative Supplement;Affect;Age;age-related disease;Aging;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Architecture;Biological Markers;Biopsy;Bypass;Cerebrospinal Fluid;Chronic Kidney Failure;Clinic;Clinical;clinical practice;Cognitive;cohort;Computer Analysis;Consumption;cost;Data;Data Analyses;data mining;data quality;Data Set;Data Sources;deep learning;deep learning model;dementia risk;Development;Diabetes Mellitus;Diagnostic;Differential Diagnosis;Disseminated eosinophilic collagen disease;early awareness;Educational Status;effectiveness evaluation;Elderly;Electronic Health Record;empowerment;Engineering;Epidemiology;Evaluation;Evaluation Research;Face;feasibility research;feature selection;General Population;Genetic Markers;genetic testing;Graph;Growth;human old age (65+);idiopathic pulmonary fibrosis;Impaired cognition;Individual;Informatics;Information Management;Investigation;Kidney Calculi;Knowledge;Knowledge Discovery;knowledge hub;Life Style;Literature;Machine Learning;Magnetic Resonance Imaging;Manuals;mastocytosis;Mental Depression;Methodology;Methods;Modality;Modeling;Molecular;multimodality;Natural Language Processing;neuroimaging;novel;Obesity;parent grant;Parents;Patients;Performance;Phenotype;Physicians;Physiological;Population;Positioning Attribute;precision medicine;predictive modeling;prevent;prognostic model;PubMed;Rare Diseases;Recurrence;Research;response;Risk;Risk Assessment;Risk Factors;risk prediction model;Series;Signs and Symptoms;Speed;Stroke;System;Techniques;Testing;Text;text searching;Time;tomography;tool;Translating;United States;Universities;uptake;usability;Visit;web portal;Work

PROJECT_TITLE: Predictive modeling of Alzheimer's Disease Related Dementias (ADRD) in the elderly population empowered by knowledge-driven data mining

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Gut microbes and host cells are connected within an intricate bioelectrical network, with microbial electrical signals potentially shaping gut health and broader host-wide functions. This project delves into a previously unexplored aspect of the gut microbiota: bacterial electro-signaling via extracellular, conductive nanowires. By investigating bioelectrical communication along the gut-host axis, we aim to unveil new avenues for gut-focused therapeutics.

PI_NAMEs: NEEDHAM, BRITTANY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Characterizing bioelectrical signaling between the gut microbiota and the host

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research details the development of reaction methodology to enable molecular rigidification. We will develop stoichiometric dialkyl carbene transfer reactions using alkyl sulfones as carbene precursors to obtain chiral orphaned cyclopropanes and apply this reaction to the synthesis medium-ring heterocycles and the synthesis of the antifungal compound jawsamycin. Simultaneously, we will study the mechanism of Pd and Ni- catalyzed dialkylcarbene transfer reactions, which will enable access to medicinally relevant bioisosteres such as [2.1.0]-bicyclopentanes (housanes), annulated heterocycles, and cerorubenic acids I, II and III.

PI_NAMEs: WILKERSON-HILL, SIDNEY MALIK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Development and Applications of Reactions to Enable Molecular Rigidification


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The project will develop accurate and efficient computational models to characterize molecular structures within cytoplasmic condensates. These models will be used to study the interplay between RNA-binding proteins, RNA, and small molecules inside condensates, particularly stress granules. This work will facilitate therapeutic design to target condensate-related diseases.

PI_NAMEs: JOSEPH, JERELLE AURELIA (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Agreement;Binding;Biophysics;cell assembly;Communicable Diseases;Complex;Computer Models;Cytoplasm;Data;data integration;design;Disease;Drug Design;Drug Targeting;Evaluation;Health;insight;Malignant Neoplasms;Maps;Membrane;Messenger RNA;Modeling;models and simulation;Molecular Structure;Neurodegenerative Disorders;Nucleic Acids;Pharmaceutical Preparations;Physical condensation;Property;Proteins;Research;Resources;RNA;RNA-Binding Proteins;Role;Shapes;simulation;small molecule;stress granule;Structure;Therapeutic;Time;Work

PROJECT_TITLE: Inside Condensates: Bridging molecular structure and condensate material properties through simulation


ORG_CITY: MORGANTOWN

ORG_DEPT: BIOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE My research focuses on understanding the underlying principles and mechanisms that enable an animal's body plan to regenerate, using the experimentally tractable research model planaria. Through my recent work, I have discovered that Hox genes play a crucial role in restricting body size and facilitating asexual reproduction, both of which are functionally linked with the planarian's impressive regenerative abilities. My lab is now poised to delve deeper into the molecular mechanisms behind how Hox genes regulate body size, how that size regulation facilitates regenerative processes, and how Hox functions in asexual reproduction are molecularly intertwined with the ability to regenerate the entire body.

PI_NAMEs: ARNOLD, CHRISTOPHER PAUL (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Affect;Anatomy;Animals;Asexual Reproduction;Body Size;Cells;Complex;Data;Development;Developmental Gene;Dissection;Evolution;Foundations;gene conservation;Gene Expression Regulation;gene function;gene regulatory network;Genes;Genetic Transcription;Health;Homeobox Genes;Human;improved;insight;interest;Invertebrates;Knowledge;Link;Modeling;Modification;Molecular;Molecular Analysis;Natural regeneration;novel strategies;Organism;permissiveness;Planarians;Platyhelminths;Play;Process;Property;regenerative;Regenerative capacity;Regenerative Medicine;Regulation;Research;RNA interference screen;Role;tissue regeneration;Tissues;Vertebrates;Work

PROJECT_TITLE: Hox gene regulation of body size and asexual reproduction underlie regenerative abilities


NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE This research will answer key questions about predictors for heterogeneity of individual treatment responses and alleviate the problem of robustness of prediction models across populations. Our results will shed light on the markers leading to individual variations in treatment responses, enable better risk assessment, and ultimately provide the key to personalized medicine.

PI_NAMEs: CHIU, YU-HAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Algorithms;Big Data;Biology;Clinical;Complex;Coronary Arteriosclerosis;Data;Data Science;Development;Disease;Disease Management;Evaluation;Health;Heterogeneity;high dimensionality;high throughput technology;improved;Individual;individual response;individual variation;inter-individual variation;large scale simulation;large-scale database;Machine Learning;machine learning method;Methods;Modeling;novel;Participant;Patient-Focused Outcomes;Patients;personalized medicine;Population;Prediction of Response to Therapy;predictive modeling;prevent;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Risk Assessment;Sampling;Source;Subgroup;Target Populations;tool;treatment effect;treatment response

PROJECT_TITLE: Uncovering Heterogeneity in Individual Treatment Responses via Causal Machine Learning


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The key clinical hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ) plaque and synaptic degeneration which are observed in both the brain and the retina. This project is aimed to study the molecular mechanism through which Aβ induces synaptic degeneration in the retina with a specific focus on a previously identified molecule α2δ4 and its downstream signaling. The results from the proposed research will advance our understanding of retinal changes in AD and AD pathology overall and facilitate mechanism-based AD clinical interventions.

PI_NAMEs: WANG, YUCHEN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Biochemical;Biochemical Pathway;Biological Markers;Brain;brain dysfunction;Calcium Channel;Cell Adhesion Molecules;Cells;Central Nervous System;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive performance;Complex;Data;Data Set;Dementia;Deposition;DNA Sequence Alteration;early detection biomarkers;extracellular;Functional disorder;Future;gene-editing approach;Genetic;Goals;Homeostasis;Human;human disease;Impairment;in vivo;Individual;information processing;Intervention;Lead;Link;Mediating;Mediator;Modeling;Molecular;Molecular Profiling;Monitor;Morphology;Neurons;neurotransmitter release;patch clamp;Pathologic;Pathology;Photoreceptors;postsynaptic;presynaptic;Property;Proteins;Proteomics;Research;Retina;Retinal Diseases;retinal neuron;Retinal Photoreceptors;Role;Senile Plaques;Signal Pathway;Signal Transduction;Site;Synapses;synaptic function;Synaptic Receptors;synaptogenesis;Transfection;virtual;visual information;voltage;Work

PROJECT_TITLE: Trans-synaptic mechanism of retinal synapse formation and function

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cell migration is utilized many times in human health including embryonic tissue morphogenesis, immune cell surveillance, and cancer cell metastasis – each of these events require careful communication with the surrounding environment through the plasma membrane. Thus, a comprehensive understanding of how the plasma membrane is organized during in vivo cell migration is critical to understand the basic mechanisms underlying migratory cell behavior. Research in my laboratory will interrogate the role of plasma lipid metabolism in regulating membrane organization, fluidity, and cell signaling during in vivo cell migration with the ultimate goal of identifying new strategies to combat aberrant cell migration during development and disease.

PI_NAMEs: PIACENTINO, MICHAEL LOUIS (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Award;Behavior;biophysical properties;Birds;cancer cell;cell behavior;Cell membrane;cell motility;Cells;Chemotaxis;combat;Communication;Complex;Destinations;Development;Diffusion;Disease;embryo cell;embryo tissue;Environment;Event;experimental study;fluidity;Genes;Goals;Health;Human;Human Development;human disease;Immune;improved;in vivo;in vivo Model;Individual;Inflammation;knock-down;Laboratories;lipid metabolism;Lipids;live cell imaging;Measures;Mechanics;Membrane;Membrane Fluidity;Membrane Proteins;migration;Morphogenesis;Neoplasm Metastasis;Neural Crest Cell;optogenetics;Plasma;Play;Population;Positioning Attribute;prevent;Process;Proteins;receptor;Research;response;Role;Signal Transduction;Stimulus;Testing;Tissues;Visualization;Work;wound healing

PROJECT_TITLE: Determining how membrane fluidity regulates embryonic cell migration


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project aims to identify how lysosomes and other cell fate determinants are segregated during division and regulate hematopoietic stem cell fates. Our novel insights will help to develop novel culture conditions that increase symmetric lysosome segregation to manipulate cell fate decisions for more efficient HSC expansion. In addition, this study will provide the basis to study how aberrant cell fate decisions arise during diseases.

PI_NAMEs: LOEFFLER, DIRK  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Actins;Address;Affect;ANGPTL2 gene;Behavior;Biological Assay;Blood Cells;CDC42 gene;cell behavior;Cell Count;Cell Differentiation process;Cell Fate Control;Cell Physiology;Cell Polarity;Cell Separation;Cell Transplantation;Cells;Coupled;curative treatments;Cytoskeletal Filaments;Cytoskeleton;Data;Daughter;daughter cell;Decision Making;differentiation in vitro;Disease;Event;Filament;Focal Adhesion Kinase 1;Focal Adhesions;Generations;Genetic;genetic manipulation;hematopoietic differentiation;Hematopoietic Neoplasms;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Imaging Device;Imaging Techniques;improved;in vivo;inhibitor;insight;Integrins;Interphase Cell;Invertebrates;Knowledge;Leukemic Cell;leukemogenesis;Life;live cell imaging;Lysosomes;Mediating;Metabolism;Microfilaments;Modeling;Motility;Motor;new technology;novel;Pathway interactions;pharmacologic;polymerization;Polymers;predictive modeling;Process;Property;Proteins;Regulation;Research;Resolution;rho GTP-Binding Proteins;Role;Sampling;segregation;self-renewal;stem cell division;stem cell function;Surface;System;Technology;Testing;Three-Dimensional Imaging;Time;tool;Tubulin;Vimentin;Visualization

PROJECT_TITLE: Investigating the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Immunotherapy;Microbiome;Nutrition;Orphan Drug;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: The Duke consortium has been a member of the Blood and Marrow Transplant Clinical Trials Network (BMTCTN) since its inception in 2001 and has contributed significantly to its mission. The research proposal in this application proposes a timely and potentially practice changing study of the dietary supplement and prebiotic galactooligosaccaride. If successful, this intervention could improve the outcome of patients with life- threatening blood disorders who are being treated with allogenic hematopoietic stem cell transplantation.

PI_NAMEs: HORWITZ, MITCHELL E (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Abdominal Pain;Accreditation;Acute Graft Versus Host Disease;Adult;Age;Allogenic;Anti-Inflammatory Agents;Antibiotics;Award;Bacteria;bacterial community;Bacteroides;Basic Science;Bifidobacterium;Blood;Bone Marrow Transplantation;Butyrates;Cell Therapy;Cessation of life;Characteristics;Child;Childhood;chronic graft versus host disease;Clinical;Clinical Data;Clinical Research;Clinical Trials Network;Colon;Consumption;cytokine;Data;Decision Making;dietary;dietary supplements;Disease;Disease-Free Survival;Double-Blind Method;double-blind placebo controlled trial;emotional distress;Energy-Generating Resources;Enrollment;Ensure;Epithelial Cells;Equilibrium;ethnic diversity;Event;Evolution;experience;Feces;Fiber;Food Additives;Funding;gastrointestinal symptom;graft vs host disease;Growth;gut bacteria;gut microbiome;Health;Hematological Disease;Hematopoietic Stem Cell Transplantation;Human;immune function;immune reconstitution;immunoregulation;improved;improved outcome;Infection;Infusion procedures;Interleukin-1 beta;Interleukin-10;Intervention;Intestines;Lead;Life;Link;Maintenance;maltodextrin;Manufacturer;Measures;Mediating;member;Mental Health;Metabolic;Metabolism;microbiome;microbiota transplantation;microorganism;Mission;Mus;Natural Killer Cells;North Carolina;nutrient absorption;Oligosaccharides;Outcome;Patient-Focused Outcomes;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phase;phase 2 study;phase 3 study;phase III trial;placebo controlled study;Placebos;Play;Population Heterogeneity;pre-clinical;prebiotics;preservation;prevent;primary endpoint;Production;programs;Prophylactic treatment;Protocols documentation;Publishing;Quality of life;racial diversity;Randomized;recurrent infection;Regimen;Regulation;Regulatory T-Lymphocyte;Relapse;Research Proposals;Role;Safety;Site;Stem cell transplant;stem cells;stool sample;Study Subject;Supportive care;Systemic Therapy;T-Cell Development;Techniques;Testing;Toxic effect;Transplant Recipients;Transplantation;Transplantation Conditioning;transplantation therapy;treatment arm;treatment center;Universities;Virginia;Volatile Fatty Acids;Weight

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Public health gains could be substantial if people who use combusted cigarettes, the most harmful nicotine delivery products, switch to a less harmful nicotine product. This research will examine the ability of 3-mg and 6-mg nicotine pouches to serve as a replacement for cigarettes during a 3-week switching trial and compare them to nicotine mini lozenges or no-study product. This data could inform regulatory policy decisions regarding the public health impact of nicotine pouches.

PI_NAMEs: PIASECKI, THOMAS M;PIPER, MEGAN E (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Address;Adopted;Adult;Affect;arm;Automobile Driving;Cause of Death;Cessation of life;Chemicals;Cigarette;cigarette smoke;cigarette smoking;Clinic;comparative effectiveness trial;craving;Data;Disease;Dose;Electronic cigarette;Electronics;Enrollment;Evaluation;Evaluation Studies;Event;FDA approved;Fiber;head-to-head comparison;Health;Health Promotion;Individual;innovation;Interview;Laboratories;Malignant Neoplasms;Marketing;Mastication;modifiable risk;Nicotine;nicotine cessation;nicotine replacement;nicotine self-administration;Odors;Oral;Oral Tobacco;Participant;Pattern;Persons;Pharmaceutical Preparations;Plant Leaves;Policies;Powder dose form;pressure;primary outcome;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;Resources;Respiratory System;Rewards;Risk;Risk Factors;Role;Sampling;satisfaction;smartphone application;Smoke;Smoker;Smoking;smoking cessation;smoking restriction;Taste Perception;Testing;Time;time use;Tobacco;Tobacco Industry;tobacco products;Tobacco use;tobacco-free;toxicant;Uncertainty;United States;Visit;Withdrawal;Withdrawal Symptom;Youth

PROJECT_TITLE: A randomized comparative effectiveness trial of nicotine pouches for cigarette substitution: A question of public health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-E (56)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHYSIOLOGY

PHR: NARRATIVE Mitochondria play a central role in cellular energy production, metabolism, and the maintenance of redox homeostasis. We discovered a novel signaling pathway in the mitochondria mediated by reversible protein AMPylation. This project aims to determine the mechanisms and importance of mitochondrial protein AMPylation, which impacts both physiological and pathological processes.

PI_NAMEs: SREELATHA, ANJU  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Adenosine Monophosphate;Amino Acids;Area;Bacteria;Binding;Biochemical;Biological;Biology;Detection;Development;Disease;Endoribonucleases;Engineering;Enzymes;Escherichia coli;Eukaryota;Excision;Goals;Health;Homeostasis;Homologous Gene;Human;Hypertrophic Cardiomyopathy;In Vitro;in vivo;infancy;insight;Knowledge;Life;Maintenance;Malignant neoplasm of prostate;Mediating;Metabolism;Mitochondria;Mitochondrial Proteins;Molecular;Mutagenesis;Mutation;novel;novel strategies;Organelles;Oxidation-Reduction;Pathologic Processes;Phosphorylation;Phosphotyrosine;Physiological Processes;Play;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Production;Proteins;Regulation;Research;Ribonucleases;RNA;RNase Z;Role;selenoprotein;Signal Pathway;Signal Transduction;Signaling Protein;src Homology Region 2 Domain;Structure;Techniques;Therapeutic;tool;Transfer RNA;tRNA Precursor

PROJECT_TITLE: Regulation of mitochondrial signaling by protein AMPylation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Orphan Drug;Patient Safety;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE City of Hope, as a Core Clinical Center of the Blood and Marrow Transplant Clinical Trials Network, proposes to continue leadership in the development and execution of prospective clinical trials addressing key issues in hematopoietic cell transplantation (HCT). We also propose a Phase 2, platform clinical trial of post-HCT maintenance therapeutics in patients undergoing allogeneic HCT for treatment of TP53-mutated AML or MDS, to be conducted by BMT CTN. This study addresses a true unmet need in this high-risk patient population, using novel approaches to improve HCT outcomes by post-HCT maintenance therapy and increase access to HCT and maintenance through a multidisciplinary team intervention in older or clinically infirm patients.

PI_NAMEs: NAKAMURA, RYOTARO  (contact)

PROJECT_TERMS: Address;Adult;Aging;AIDS-Related Lymphoma;Allogenic;AML/MDS;Applications Grants;Area;arm;Azacitidine;Biological Markers;Biology;Blocking Antibodies;Blood;Bone Marrow Transplantation;California;cancer cell;Caring;CD47 gene;Cell Maintenance;Cell Therapy;Cities;Clinic;Clinical;clinical center;clinical development;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Committee Members;conditioning;curative treatments;Cyclic GMP;Cytomegalovirus Infections;Data;Development;Disease;disorder prevention;Drug Metabolic Detoxication;Eating;efficacy evaluation;Elderly;Enrollment;experience;FDA approved;frailty;Funding;Goals;graft vs host disease;Grant;health assessment;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;HIV;human old age (65+);Immunologic Factors;improved;improved outcome;Incidence;Infusion procedures;Institution;interdisciplinary approach;Intervention;investigator-initiated trial;Laboratories;Laboratory Research;Leadership;Maintenance;Maintenance Therapy;Malignant - descriptor;manufacturing facility;Measures;Medical center;member;Modeling;Monoclonal Antibodies;mortality;multidisciplinary;Multiple Myeloma;Mutate;Mutation;Non-Malignant;novel;novel strategies;older adult;Outcome;overexpression;patient population;patient subsets;Patients;pediatric patients;Pediatrics;Performance Status;Phase;Process;programs;Progression-Free Survivals;prospective;protocol development;Protocols documentation;Quality of life;Recovery;Recovery of Function;Regenerative Medicine;Relapse;Request for Applications;Research Institute;Research Personnel;resilience;Review Committee;Science;Signal Transduction;Source;Southwest Oncology Group;standard care;stem cells;Survival Rate;survivorship;symposium;T cell therapy;Testing;Therapeutic;therapeutically effective;TP53 gene;TP53-mutant acute myeloid leukemia;Transfusion;Translational Research;transplant centers;Transplant Recipients;transplantation therapy;United States National Institutes of Health;Work

PROJECT_TITLE: BMT CTN Core - City of Hope National Medical Center


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE In addition to supporting sight, light regulates diverse aspects of physiology and behavior. In mammals, the intrinsically photosensitive retinal ganglion cells are essential for this regulation. We propose to develop basic knowledge of these cells and thereby deepen the foundation for improving health; for example, light acts through ipRGCs to regulate the circadian clock, and circadian dysregulation is implicated in cancer, cardiovascular disease, metabolic disorder, and mental illness.

PI_NAMEs: DO, MICHAEL TRI HOANG (contact)

PROJECT_TERMS: Address;Afferent Neurons;Agitation;Automobile Driving;Behavior;Behavioral;biophysical tools;Brain;Brain region;Budgets;Calcium;Cardiovascular Diseases;Cell Separation;cell type;Cells;cellular transduction;Circadian Dysregulation;circadian pacemaker;Closure by clamp;Communication;Cone;Electrophysiology (science);Event;experimental study;Eye;falls;Fire - disasters;Foundations;Frequencies;Funding;G-Protein-Coupled Receptors;Generations;Health;improved;innovation;insight;Ion Channel;Ion Channel Gating;Knowledge;Learning;Light;Lighting;Link;Malignant Neoplasms;Mammalian Cell;Mammals;melanopsin;Mental Depression;Mental disorders;Metabolic Diseases;Methods;Miosis disorder;model organism;Molecular;Moods;Mus;Nervous System;neural;Neurons;neurophysiology;Noise;Output;pandemic disease;patch clamp;Perforation;Photons;Photoreceptors;Phototransduction;Physiological;Physiology;Play;Process;Property;Regulation;Reporter;Reporting;Research;response;Retina;Retinal Cone;Retinal Ganglion Cells;Rod;Role;Sensory;Shapes;Signal Transduction;Sleep;sleep regulation;spatiotemporal;Stimulus;Stream;Techniques;Testing;Time;Variant;Vertebrate Photoreceptors;Vision;voltage;voltage clamp

PROJECT_TITLE: Neurophysiology of Melanopsin Photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative Autophagy is an essential cellular pathway which maintains cellular health by degrading toxic cargo. Impairment of membrane tethering in the autophagy pathway is linked to neurodegeneration, microbial infections, and cellular aging diseases. Our research aims to understand the mechanistic interactions of how multifunctional scaffolding proteins target, organize, and promote autophagy completion.

PI_NAMEs: YOKOM, ADAM LEE (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: aging related disease;Autophagocytosis;Autophagosome;Binding;Biological;Biology;Cell Aging;Cell Physiology;Cells;Cellular Stress;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasmic Granules;Data;Defect;Encapsulated;Environment;Event;Family;Foundations;Goals;Health;Homeostasis;Homologous Gene;Human;human disease;Impairment;improved;In Situ;In Vitro;in vivo;Infection;innovation;Ions;Lead;Link;Lipids;Lysosomes;member;Membrane;Methods;microbial;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;Organelles;particle;Pathway interactions;PH Domain;protein protein interaction;Protein Sortings;Proteins;Research;Resolution;scaffold;Scaffolding Protein;Shapes;Site;Specificity;Stress;Surface;Techniques;tool;Vacuole;Work

PROJECT_TITLE: Mechanisms of membrane tethering in autophagy

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prostate Cancer;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Prostate cancer is the most prevalent neoplasm in the male population worldwide, and MRI is now a key modality for detection and biopsy guidance of clinically significant prostate cancer. Due to suboptimal sensitivity of current MRI techniques, 30% of patients with a negative MRI still end up proceeding to invasive biopsy, which leads to unnecessary treatment and post-procedure complications. As experts in Magnetic Resonance Fingerprinting and prostate diagnoses along with expertise in artificial intelligence, we aim to develop novel quantitative imaging biomarkers to improve the characterization of prostatic tissues to ensure optimal detection of clinically significant prostate cancer while avoiding overdiagnosis and unnecessary procedures.

PI_NAMEs: CHEN, YONG ;KAYAT BITTENCOURT, LEONARDO  (contact);MA, DAN

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acceleration;Adoption;Affect;Artificial Intelligence;Biopsy;Cessation of life;Clinical;clinical practice;clinical risk;clinically significant;Consumption;cost;Data;deep learning;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Ensure;Evaluation;Evolution;Financial Hardship;Fingerprint;Gland;Goals;Heterogeneity;Image;imaging biomarker;Imaging Techniques;improved;Information Systems;International;Lesion;Magnetic Resonance;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Maps;Measurement;men;Methods;Modality;Morphologic artifacts;mortality;Motion;MRI Scans;Neoplasms;non-invasive imaging;novel;overtreatment;Patient Care;Patients;Peripheral;Physics;Population;predictive modeling;Predictive Value;Predisposition;Preparation;Prevalence;Procedures;Prospective cohort;Prostate;Prostatic;Prostatic Tissue;Quality of life;quantitative imaging;Reader;Reporting;Reproducibility;research clinical testing;Risk;Scanning;screening;Screening for Prostate Cancer;Signal Transduction;Slice;spatiotemporal;Standardization;Structure of base of prostate;success;Survival Rate;System;Techniques;Time;Tissues;tool;treatment strategy;Uncertainty;United States;Unnecessary Procedures;unnecessary treatment;Variant;volunteer;Western World

PROJECT_TITLE: Development of fast diffusion magnetic resonance fingerprinting of the prostate to avoid unnecessary biopsies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is one of the leading causes of death and disability and represents the most well- established environmental risk factor for cognitive impairment, progression to clinical Alzheimer’s disease (AD) and AD related dementia (ADRD). This project will employ a perfused blood-BBB/NVU interface model which allows us to examine the relationship between blood components and BBB/NVU function relevant to TBI with/without cognitive decline and AD progression.

PI_NAMEs: AGALLIU, DRITAN  (contact);PEDERSEN, IRENE MUNK

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 3-Dimensional;Acute;adaptive immune response;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;angiogenesis;Basement membrane;Blood;Blood - brain barrier anatomy;blood perfusion;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain Injuries;Cause of Death;Cell Communication;Cell Cycle Kinetics;cell type;Cells;Cellular biology;Cerebrovascular system;Characteristics;Chronic;Clinical;Cognitive deficits;cohort;Collaborations;Communication;comparison control;Data;Dementia;Development;Diagnosis;disability;Disease;Disease Progression;Environmental Risk Factor;experimental study;Exposure to;Functional disorder;Funding;Gills;Goals;Grant;Hemorrhage;Hippocampus;Human;Image;imaging study;Immune;immune activation;Immune response;Immunomodulators;Impaired cognition;Impairment;In Vitro;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Maintenance;Microfluidics;Modeling;Molecular;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic;neurological pathology;Neurons;novel;parent grant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Pericytes;Peripheral;Permeability;Phase;potential biomarker;Prevention;Progressive Disease;Property;Proteins;repaired;Research;Risk;Role;Sampling;service member;Survivors;Symptoms;Testing;therapeutic development;therapeutic target;three-dimensional modeling;Time;transcriptomics;Traumatic Brain Injury;Vascular remodeling;Vascularization;Veterans;Work;wounded service member

PROJECT_TITLE: Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB model


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE Although high-throughput screening yields a number of small-molecule modulators of biomedically relevant proteins, these ‘hits’ typically require substantial optimization to improve their biological functions via costly medicinal chemistry approaches, creating a significant hurdle to development of efficacious chemical probes and drugs. The proposed research program aims to address this limitation through two complementary research directions focused on developing generally applicable medicinal chemistry workflows for underexplored biological targets. Ultimately, application of these approaches and the resulting probes will advance our fundamental understanding of living systems and provide proof-of-concept for novel therapeutic mechanisms of action, thereby enhancing human health.

PI_NAMEs: KITAMURA, SEIYA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Expanding the chemical probe development paradigm toward underexplored targets

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: Project Narrative. As the cases of Alzheimer’s disease and related dementias (ADRD) continue to grow worldwide, it is critical more than ever to improve our identification of those at greatest risk for ADRD earliest in the disease process. Mild cognitive impairment (MCI) is meant to capture individuals in the prodromal phase between cognitively healthy and dementia, yet not everyone diagnosed with MCI eventually progresses to dementia. By harmonizing large longitudinal population-based studies in the United States, Mexico, and India, we will be able to uncover, from a global perspective, the sociodemographic, health, and biological factors that predict progression from MCI to dementia.

PI_NAMEs: ARCE, MIGUEL  (contact);BRICENO, EMILY MARIE

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adult;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Ancillary Study;apolipoprotein E-4;Biological;Biological Factors;Biological Markers;blood-based biomarker;Cardiovascular Diseases;Cardiovascular system;Characteristics;Classification;Cognition;Cognitive;Cognitive aging;cognitive performance;cognitive testing;Country;Data;data harmonization;Dementia;dementia burden;dementia risk;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Early identification;Early Intervention;Economics;Education;Educational Status;Exposure to;Future;Gender;Genetic;Goals;Growth;Health;health data;Healthcare;high risk;illiteracy;Impaired cognition;improved;Income;India;Individual;informant;instrument;Intervention;Knowledge;Life Cycle Stages;Life Experience;Life Style;Linguistics;literacy;longitudinal course;low and middle-income countries;Measurement;Measures;Meta-Analysis;Metabolic;Metabolic Diseases;Methods;Mexican;Mexico;mild cognitive impairment;older adult;Pathway interactions;Phase;Population;population based;Population Study;Predictive Factor;Prevalence;Prevention strategy;preventive intervention;Process;Prognosis;prospective;Protocols documentation;Retirement;Risk;Risk Factors;rural residence;Sampling;sex;social;social culture;sociodemographics;study population;tau Proteins;Time;United States;Variant;Work

PROJECT_TITLE: Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias: Cross-national longitudinal prognosis and risk factors


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Where one lives is an important contributor to disparities in health behaviors and outcomes. It has been difficult to draw firm conclusions on the relations between regional/neighborhood contexts and alcohol misuse. The results of this project will enhance our understanding of the relation between neighborhood contexts and alcohol misuse from adolescence through mid-adulthood, that may inform the development of more effective, tailored programs of prevention and intervention.

PI_NAMEs: SLUTSKE, WENDY S (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Accounting;Address;Adolescence;Adolescent;Adult;Age;age difference;Alcohol consumption;alcohol involvement;alcohol misuse;Alcohols;Area;Behavior;binge drinking;Censuses;cohort;County;critical period;Data;Data Analyses;Data Collection;Databases;Development;Disadvantaged;Dizygotic Twins;DNA;drinking;Education;Environment;Environmental Risk Factor;Etiology;Exposure to;Family;follow-up;Frequencies;gene environment interaction;Genes;Genetic;genetic information;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Risk;genetic selection;Genotype;Goals;Health;Health behavior and outcomes;health disparity;high risk;high school;Home;improved;Income;Individual;Individual Differences;insight;Intervention;intervention effect;Link;Literature;Longitudinal Studies;longitudinal, prospective study;Measures;Mental Depression;Monozygotic twins;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;Participant;Personality;polygenic risk score;Poverty;Prevalence;Prevention;Prevention program;prospective;Religiosity;Research;Risk;Rural;Sampling;secondary analysis;Siblings;social;Source;Testing;Twin Multiple Birth;Unemployment;urban residence;Vulnerable Populations

PROJECT_TITLE: Genes, neighborhoods, and alcohol misuse from adolescence to mid-adulthood in the Add Health study

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Data Science;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE This study is highly relevant to public health because personalized risk prediction and treatment optimization will reduce the hematologic disease burden among patients with myeloid malignancies. The proposed causal machine learning methods will effectively integrate large and multi-modal biomedical datasets for individualized comorbidity management, which will contribute to NIH’s mission to improve disease prevention and treatment.

PI_NAMEs: YU, KUN-HSING  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adverse event;Affect;Age;Algorithms;Anticoagulation;Antiplatelet Drugs;Artificial Intelligence;Biological;Blood Cell Count;Bone Marrow;Bone marrow biopsy;burden of illness;Cancer Patient;Cancer Survivor;cancer therapy;Cardiovascular system;causal model;Characteristics;Clinical;clinical center;Clinical Data;Clinical Management;clinical predictive model;clinical predictors;Coagulation Process;combinatorial;Combined Modality Therapy;comorbidity;Data;Data Set;data-driven model;digital;disorder prevention;dosage;Dysmyelopoietic Syndromes;empowerment;Event;genetic predictors;genomic profiles;Genomics;Goals;Graph;Hematological Disease;Hematologist;Hematology;Heme;Hemorrhage;Hemostatic Agents;Hemostatic function;Heterogeneity;human old age (65+);Image;improved;individualized medicine;innovation;Intervention;Israel;Knowledge;Laboratories;Life;Link;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;machine learning model;machine learning prediction;Methods;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;multimodal fusion;multimodal learning;multimodality;multiple datasets;Myelogenous;Myeloproliferative disease;National Heart, Lung, and Blood Institute;novel;Oncologist;Pathology;Patients;personalized care;personalized decision;personalized management;personalized medicine;personalized risk prediction;Philadelphia Chromosome;predictive modeling;prevent;profiles in patients;Prophylactic treatment;Public Health;Recommendation;Recording of previous events;Resolution;Risk;Risk Assessment;risk minimization;risk mitigation;risk prediction;sex;Signal Transduction;Suggestion;Survivors;targeted sequencing;Test Result;Thrombocytopenia;Thrombosis;thrombotic;treatment optimization;Treatment Protocols;treatment strategy;tumor progression;United States National Institutes of Health;Validation

PROJECT_TITLE: Mitigating Hematologic Adverse Events in Patients with Myeloid Malignancies: A Novel Causal Artificial Intelligence Approach

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Underage Drinking;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PROJECT NARRATIVE Despite the known adverse effects of genetic risk for Alzheimer’s disease and its related dementias (including Apolipoprotein (APOEε4) and related variants), chronic alcohol misuse, traumatic stress, and PTSD on brain health, there are few studies that have specifically examined the relationship between Alzheimer’s disease and related dementias (ADRD) in this context. In response to NOT-AG-23-032, which requests administrative supplements for existing NIH grants to develop a new focus on ADRD, the primary aim of this study is to investigate the association of genomic risk for ADRD (including and excluding APOEε4) with longitudinal measures of brain functioning (i.e., neural connectivity), and the role of alcohol use behavior, traumatic stress and PTSD. Study findings will enhance understanding of how Alzheimer’s risk factors (genetics, problematic alcohol use, traumatic stress, PTSD, neural development) typically studied later in life, manifest earlier in the lifespan, and inform interventions or preventive measures that may help prevent downstream health conditions.

PI_NAMEs: AMSTADTER, ANANDA B;MEYERS, JACQUELYN LEIGH (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acceleration;Administrative Supplement;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Age of Onset;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol use disorder;alcoholism therapy;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-4;Apolipoproteins;Behavior;behavioral phenotyping;binge drinking;Biocompatible Materials;Black race;Brain;brain health;Brain region;Childhood;Chronic;Clinical;Clinical assessments;Cognitive;cognitive function;cognitive process;Communities;comorbidity;Complex;Conduct Disorder;Data;Dementia;dementia risk;design;Development;Diagnosis;Diagnostic;Disease;DNA;drinking;DSM-V;Electroencephalography;Environmental Risk Factor;Exclusion;Extended Family;Eye;Family;Female;Frequencies;Generations;Genetic;Genetic Risk;genetic risk factor;Genetic study;genetics of alcoholism;genome wide association study;Genomics;Goals;Grant;Health;Heavy Drinking;Hispanic;Impaired cognition;Impairment;Impulsivity;Individual;innovation;Intervention;Interview;Life;life span;Long-Term Effects;longitudinal, prospective study;Measures;Memory;Mental disorders;Meta-Analysis;mild cognitive impairment;millisecond;Modeling;Motor;Nature;neural;neural network;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Outcome;parent project;Participant;Pattern;pediatric trauma;Phenotype;polygenic risk score;Post-Traumatic Stress Disorders;Premature aging syndrome;prevent;Preventive measure;proband;Prospective Studies;protective allele;public health relevance;Recording of previous events;recruit;Research;response;Rest;Risk;risk variant;Role;Sampling;Sensory;Severities;statistics;Structure;substance use;Symptoms;temporal measurement;Trauma;trauma exposure;traumatic stress;United States National Institutes of Health;Variant;Work;young adult

PROJECT_TITLE: Genetic relationships between PTSD and Alcohol Use Disorder: Integrating GWAS and Deeply Phenotyped Longitudinal data.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This research program will elucidate the rules governing the binding of proteins to DNA and the contributions of epigenetics, co-factors, and chromatin to modulate binding. Understanding these rules and how aberrant binding of proteins can occur will provide greater insight into the nature of gene mis-regulation and subsequent disease progression.

PI_NAMEs: LAI, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Algorithms;artificial intelligence algorithm;Base Pairing;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Cell Nucleus;Cells;Chromatin;cofactor;Complex;Confounding Factors (Epidemiology);Disease;Disease Progression;DNA;DNA Methylation;Epigenetic Process;Gene Expression Regulation;Genes;Genome;genome-wide;Genomic approach;Genomic DNA;Genomics;Goals;Homeostasis;Human;insight;interest;Language;Liquid substance;machine learning algorithm;Mass Spectrum Analysis;model organism;Nature;Organism;Pattern;preference;programs;Proteins;Research;Resolution;robotic system;Robotics;Source;Specificity;Time;transcription factor;Yeast Model System

PROJECT_TITLE: Deconvolving the language of protein binding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative In proliferating cells, metabolism must be coordinated with the cell cycle to meet phase-specific biosynthetic demands, but how this coordination occurs is unknown. This project will determine the role of the master metabolic regulator mTOR Complex 1 as a crucial effector through which the cell cycle orchestrates changes in metabolism. This study will provide new understanding of the mechanisms that integrate cell cycle control with cellular metabolism, critically advancing our fundamental knowledge of how cells grow and proliferate.

PI_NAMEs: VALVEZAN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acute;Cell Cycle;Cell Cycle Regulation;cell growth;Cell Proliferation;Cells;Complex;Data;Eukaryotic Cell;FRAP1 gene;Growth Factor;human disease;insight;Knowledge;Link;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitosis;Molecular;Nutrient;Phase;Play;Population;programs;Proliferating;Protein Kinase;Regulation;Research;Role;Signal Transduction

PROJECT_TITLE: Cell cycle control of cellular metabolism through phase-specific regulation of mTOR Complex 1

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative: Our program aims to build a molecular and optical cell atlas of the human inner ear as a resource for the scientific community to accelerate progress in discovering effective therapies for auditory and vestibular disorders. To achieve this objective, we will apply the latest molecular and optical imaging tools to live human inner ear tissues from organ donors, vestibular schwannoma patients, and rapid autopsy participants. We will also raise awareness of human inner ear research and enhance opportunities for collaboration by making our data and tissues widely available, by providing technical instruction, and by outreach activities.

PI_NAMEs: CHENG, ALAN GI-LUN (contact);STANKOVIC, KONSTANTINA M

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: abeta deposition;Acceleration;Acoustic Neuroma;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Atlases;Auditory;Autopsy;Awareness;Brain;Cells;cellular imaging;Cerebrospinal Fluid;Clinical;clinical imaging;Cochlea;Cochlear Diseases;Cognitive;Collaborations;Communities;Computerized Medical Record;Data;Dementia;density;Development;differential expression;Ear;Early Intervention;effective therapy;Etiology;experimental study;Grant;Hair Cells;Hearing;hearing impairment;Hearing problem;Human;Imaging Device;Instruction;Labyrinth;Link;Measures;Memory Loss;Molecular;molecular imaging;molecular marker;Nerve Degeneration;Neurofibrillary Tangles;Neurons;new therapeutic target;optical imaging;Optics;Organ Donor;outreach;Participant;Pathologic;Pathology;Patients;Perilymph;Persons;Population;potential biomarker;programs;Proteins;Proteome;proteomic signature;Reporting;Research;Resources;Risk Factors;risk stratification;semantic processing;Sensory;sound;speech in noise;spiral ganglion;Symptoms;Synapses;tau-1;Temporal bone structure;Testing;Tissues;Toxic effect;transmission process;United States;Vestibular Diseases

PROJECT_TITLE: Human Ear Cellular Atlas


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Regenerative Medicine;Rural Health;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Relevance This project seeks to enroll patients onto clinical trials that explore strategies to improve outcomes after hematopoietic stem cell transplant and genetically modified T cell therapies. Based in the Southeast, our consortium will be important in enrolling increased numbers of minorities and rural individuals to these studies. This application also proposes a clinical trial to directly compare outcomes of two currently-used methods to reduce post-transplant graft-versus-host disease, to determine if one is more advantageous than the other.

PI_NAMEs: AL-KADHIMI, ZAID ;HSU, JACK W;WALLER, EDMUND K (contact)

PROJECT_TERMS: Address;aged;Alabama;Allogenic;base;Benign;biobank;Black race;Bone Marrow;Bone Marrow Transplantation;career;career development;Cell Therapy;Cellular immunotherapy;Childhood;chimeric antigen receptor T cells;Clinical;clinical infrastructure;Clinical Research;Clinical Sciences;clinical translation;clinical trial enrollment;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Collection;Communication;Communities;community engagement;Community Outreach;conditioning;Correlative Study;CSF3 gene;Cyclophosphamide;Data;data quality;Decision Making;design;disorder risk;Dose;Effector Cell;Enrollment;Ensure;Evaluation;experience;Failure;Florida;follow-up;Fostering;frontier;Funding;Gene Modified;Geographic Locations;Geography;Goals;graft vs host disease;Growth;Health;Hematologic Neoplasms;Hematology;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Hispanic;Homologous Transplantation;Immune;improved outcome;indexing;innovation;insight;Institution;Joints;Lead;Leadership;Location;Malignant Neoplasms;Marrow;Medical;meetings;member;Methods;Minority Groups;minority patient;multidisciplinary;NCI-Designated Cancer Center;Non-Malignant;novel;Oncology;Outcome;outreach;participant enrollment;patient population;Patient Recruitments;patient subsets;Patients;Pediatrics;Peripheral Blood Stem Cell;Phase;Phase III Clinical Trials;Physicians;Population;post-transplant;preclinical development;primary outcome;programs;Prophylactic treatment;prospective;protocol development;Quality Control;Randomized;recruit;Recurrent disease;Regimen;Relapse;Research;Research Personnel;Resources;Rural Minority;rural patients;Rural Population;Sampling;Scientist;secondary outcome;Sickle Cell;Sickle Cell Anemia;Site;Source;Southeastern United States;standard of care;stem cell therapy;Stem cell transplant;stem cells;success;T cell therapy;Teleconferences;Therapy Clinical Trials;Toxic effect;Translational Research;translational study;Transplantation;trial enrollment;Underrepresented Minority;United States;Universities;Work

PROJECT_TITLE: BMT Core: Southeast Bone Marrow Transplant Consortium


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: KANSAS CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The proposed research will characterize a chemokine receptor inhibitor as a radiation countermeasure to mitigate radiation induced Paneth cell dysfunction. Paneth cells are intestinal cell type involved in intestinal epithelial homeostasis and mucosal innate immune response. This proposal will define the mechanism of action of the countermeasure which will provide data necessary for product licensure requirements according to the FDA Animal Rule.

PI_NAMEs: DIPAOLO, RICHARD J;PERRY, JOHN MARK;SAHA, SUBHRAJIT  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Address;Affect;alpha-Defensins;animal rule;antagonist;antimicrobial;Area;Body Weight;Bone Marrow;CCL2 gene;Cell Count;Cell Maturation;Cell Physiology;Cell Survival;cell type;Cells;chemokine;chemokine receptor;Collaborations;Colon;Data;Defensins;Dependence;EGF gene;Endoplasmic Reticulum;Endotoxemia;experimental study;Exposure to;extracellular;Family;Flushing;Functional disorder;Funding;gastrointestinal;Gene Expression;Geometry;Growth Factor;gut microbiota;Homeostasis;Hour;Immunofluorescence Immunologic;Impairment;Inflammation;Inflammatory;inhibitor;Injury;Innate Immune Response;Innate Immune System;Internal Ribosome Entry Site;intestinal crypt;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestinal permeability;Intestines;Ionizing radiation;irradiation;Laboratories;LGR5 gene;Licensure;Ligands;Macrophage;Mass Spectrum Analysis;Measures;Mediating;medical countermeasure;member;Methods;microbiota composition;monocyte;mouse model;Mucosal Immunity;Mucous Membrane;Muramidase;Mus;Myelogenous;National Institute of Allergy and Infectious Disease;Natural regeneration;notch protein;Organoids;Paneth Cells;Paracrine Communication;Parents;Pathway interactions;Peptides;Phenotype;Play;Population;Porcupines;Process;Proteins;Proteomics;Radiation;radiation countermeasure;Radiation exposure;Radiation Injuries;radiation mitigation;Radiation Tolerance;Radiation Toxicity;recruit;regenerative;Regulation;repaired;Reporter;Reporting;Research;response;Risk;Role;Signal Pathway;Signal Transduction;Small Intestines;Sorting;stem cell homeostasis;stem cell niche;stem cells;subcutaneous;Supporting Cell;therapeutic target;Tissue Stains;Tissues;Work

PROJECT_TITLE: Modulation of chemokine signaling to mitigate radiation induced inflammation -suppl Collab


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: While venetoclax-based therapies lead to remission for 60-70% of patients with acute myeloid leukemia (AML), the majority will relapse due to the emergence of drug resistance. We propose that clonal heterogeneity in leukemia initiating cells (LIC) underlies the failure to achieve durable responses. Here, we propose determine the characteristics of AML LIC subpopulations that mediate therapy sensitivity/resistance, in order to design combinatorial therapeutic strategies that lead to more durable remissions for patients with AML.

PI_NAMEs: DEGREGORI, JAMES V (contact);POLLYEA, DANIEL A

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Apoptosis;Apoptotic;Azacitidine;BCL2 gene;Bone Marrow;Cell Culture Techniques;Cell Death;Cells;Characteristics;chemotherapy;Clinical Trials;combinatorial;Combined Modality Therapy;Data;design;Disease;Disease remission;Disease Resistance;Drug resistance;drug resistance development;Drug usage;effective therapy;efficacy evaluation;Elderly;Exhibits;Failure;Genetic;Genetic Transcription;Genotype;Goals;Heterogeneity;Human;improved outcome;In Vitro;in vivo;in vivo Model;Individual;Induction of Apoptosis;inhibitor;inhibitor-of-apoptosis protein;Lead;leukemia initiating cell;Malignant Neoplasms;Mediating;mimetics;Modeling;Molecular;molecular phenotype;monocyte;mouse model;mutant;Mutation;Newly Diagnosed;novel strategies;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Population;Pre-Clinical Model;preclinical efficacy;Predisposition;Production;Refractory;Regimen;Relapse;Reporting;Research Personnel;Resistance;response;Safety;safety assessment;Sampling;Signal Pathway;Signal Transduction;Specimen;targeted treatment;Testing;Therapeutic;therapeutic development;therapy resistant;TNF gene;TP53 gene;TP53-mutant acute myeloid leukemia;treatment response;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: IAP inhibition as a therapeutic strategy to target therapy-resistant leukemia initiating cells

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: EB

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE The Center for Label-free Imaging and Multiscale Biophotonics (CLIMB) develops cutting-edge optical and computational imaging technologies for addressing grand challenges in biomedicine, including cancer and neurodegenerative diseases. We developed a rigorous and inclusive technology training and dissemination plan, as well as a comprehensive educational program to prepare the next generation of biophotonics researchers for excelling in label-free imaging.

PI_NAMEs: BOPPART, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Address;Adoption;Biological Markers;Biophotonics;Books;Chemicals;Clinic;clinical application;clinical practice;Clinical Research;Clinical Trials;Collaborations;commercialization;Communities;contrast imaging;Contrast Media;Cost Sharing;Decision Making;deep learning;diversity and inclusion;Education;Educational Materials;Educational workshop;Enrollment;Environment;Equipment;Evaluation;expectation;experience;Faculty;Feedback;Fellowship;Funding;Healthcare;Human;Image;imaging modality;Imaging technology;improved;in vivo;in vivo imaging;innovation;Label;Lead;Malignant Neoplasms;member;Microscopy;Minority Groups;Monitor;multimodality;Neurodegenerative Disorders;new technology;next generation;open source;operation;Optical Coherence Tomography;optical imaging;Optics;Phase;point of care;Postdoctoral Fellow;Procedures;Process;Productivity;Program Development;programs;Research;Research Personnel;residence;Resources;Schools;Series;service programs;Specificity;Specimen;Students;synergism;Technology;technology research and development;technology training;Time;tool;Training;Training Programs;Translating;Underrepresented Populations;webinar;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The mission of the PsycheMERGE Network is to advance equitable precision psychiatry in learning healthcare system frameworks across the United States. During the course of this project, an interdisciplinary team of investigators at twelve academic medical centers will bring together clinical data (>29 million individuals), genetic data (>1.9 million), and an extraordinary range of scientific expertise (psychiatry, medical informatics, machine learning, statistics, genetics, sociomedical sciences, decision sciences, and ethics) to advance this mission. We will leverage this expertise and data to build on our prior success and address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice.

PI_NAMEs: DAVIS, LEA K (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acute;Address;algorithm training;Algorithms;anti-depressive agents;Artificial Intelligence;artificial intelligence method;Attitude;Awareness;Basic Science;Big Data;biobank;Biology;Biomedical Research;Bipolar Disorder;Bipolar I;causal variant;Clinical;clinical application;Clinical Data;clinical decision support;clinical practice;Communities;Country;Data;data privacy;depressive symptoms;Development;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;Early Diagnosis;Early treatment;effective therapy;Effectiveness;Environment;Equity;Ethics;experience;federated learning;Funding;Genes;Genetic;genetic analysis;genetic association;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Health system;Healthcare Systems;improved;Individual;individual variation;Infrastructure;innovation;Label;large scale data;Learning;Left;Life Style;Machine Learning;machine learning algorithm;Maps;Medical;Medical Informatics;Medical Records;member;Mental disorders;Methods;Midwestern United States;Mission;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;network models;novel;Outcome;Patients;Pattern;Performance;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Prevention;privacy preservation;Process;Psychiatric Diagnosis;Psychiatry;Records;Research Personnel;response;risk prediction;Sampling;Science;Scientist;Site;social health determinants;Standardization;statistics;Strategic Planning;success;support tools;Testing;Time;tool;Training;transfer learning;Translational Research;Translations;treatment response;United States;Update;Validation;Vision;Work

PROJECT_TITLE: 1/7-PsycheMERGE: Advancing Precision Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Neurosciences;Opioids

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative It has been difficult to elucidate the neural mechanisms of drug action in detail using traditional pharmacological approaches that are slow and poorly localized in the brain. This work aims to develop light-activated variants of clinically used drugs that can be photoreleased in awake, behaving experimental animals to study the mechanisms of drug action with exceptional precision. These research reagents may also lead to novel phototherapies for pain and disorders involving the nervous system. 1

PI_NAMEs: BANGHART, MATTHEW R. (contact);LISTON, CONOR M

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Animal Experiments;anti-depressive agents;awake;Behavioral;Behavioral Assay;Brain;Clinical;Communities;Consultations;Development;Diffusion;Disease;drug action;Drug usage;Electrophysiology (science);Exhibits;Family;Fiber;Fluorescent Probes;fluorophore;Generations;Image;Implant;In Vitro;in vivo;Ketamine;Light;Measurement;Methods;Nervous System;neural;neurochemistry;neuromechanism;Neurophysiology - biologic function;novel;Opioid;opioid use;Optics;Pain;Penetrance;Performance;Pharmaceutical Preparations;pharmacologic;photolysis;Photometry;Photons;Phototherapy;Prefrontal Cortex;Reagent;receptor;Research;Resolution;Signal Transduction;small molecule;Specificity;Stimulus;Time;two-photon;Ultraviolet Rays;uptake;Variant;Work

PROJECT_TITLE: Development of opioid and ketamine probes for in vivo photopharmacology (Diversity Supplement)


NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Upstream open reading frames (uORFs) are associated with numerous diseases, as they regulate mRNA stability and translation. This study investigates uORF features and functions involved in mRNA decay and translation controlled by evolutionarily conserved regulators using a model system that enables in vivo and whole-organism level studies. Our findings could open doors to innovative diagnosis and treatment strategies.

PI_NAMEs: HSU, POLLY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Arabidopsis;Bioinformatics;Biological Models;Characteristics;Compensation;Data Set;Development;Diagnosis;Disease;Eukaryota;Gene Expression Regulation;genome-wide;genome-wide analysis;Growth;Health;High-Throughput Nucleotide Sequencing;Human;human disease;in vivo;innovation;Innovative Therapy;insight;machine learning model;Mediating;Messenger RNA;Metabolism;Modeling;Molecular Biology;mRNA Decay;mRNA Stability;mRNA Translation;Open Reading Frames;Peptide Initiation Factors;Phosphorylation;Plants;Play;Production;Proteins;Regulation;Repression;Research;Role;Sirolimus;System;Translating;Translational Repression;Translations;treatment strategy;Whole Organism;Work

PROJECT_TITLE: Regulation of upstream open reading frames in mRNA stability and translation

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Narrative  Chronic exposure to elevated manganese (Mn) levels, typically found in occupational environments, has been associated with olfactory dysfunction, cognitive impairment, and neurological symptoms resembling those seen in AD/ADRD. Nevertheless, the precise molecular mechanisms underlying these compromised olfaction and cognition in environmentally related AD/ADRD remain unclear. This proposal aims to investigate the involvement of a compensatory signaling pathway, mediated by the neuropeptide prokineticin 2 (PK2), in the context of an environmentally linked AD model.

PI_NAMEs: KANTHASAMY, ANUMANTHA GOUNDER (contact);KANTHASAMY, ARTHI

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: abeta accumulation;Administrative Supplement;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Astrocytes;Attention;Basal Ganglia;Behavioral;Behavioral Symptoms;Brain;Brain region;Chronic;Cognition;Cognitive deficits;Dementia;Disease Progression;Environment;Exposure to;Hippocampus;Impaired cognition;Impairment;insight;Life;Link;Manganese;Maps;Mediating;Memory;Memory impairment;Memory Loss;Metals;Molecular;mouse model;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuroinflammation;Neurologic Symptoms;neuron loss;Neurons;Neuropeptides;neuroprotection;neurotoxicity;neurotrophic factor;novel;novel therapeutic intervention;Occupational;Olfactory dysfunction;Olfactory Pathways;Parents;Pathogenesis;Pathologic;Pathology;Pathway interactions;Predisposition;protective factors;receptor;Reporting;Research;response;Role;Senile Plaques;Signal Pathway;Signal Transduction;Smell Perception;Synapses;tau mutation;tau Proteins;Testing;Up-Regulation

PROJECT_TITLE: Role of Prokineticin 2 in Metal Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]