ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Hematology;Infant Mortality;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: GAINESVILLE

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Few studies have focused on the skin microbiome from birth to a steady state in preterm infants. Early interactions between the skin and microbes are particularly important in preterm neonates, who are at increased risk for sepsis. A better understanding of the preterm infant skin microbiome, as well as microbial shifts that precede sepsis, will lead to strategies for early identification and prevention of neonatal sepsis.

PI_NAMEs: SCHOCH, JENNIFER JANE (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Antibiotics;Antisepsis;Award;Bacteria;Bathing;Bioinformatics;Birth;Candida;career;career development;career networking;Caring;Catheters;Cesarean section;Childhood;Clinical;Clinical Trials;cohort;Collection;college;Control Groups;Corynebacterium;Cutaneous;Data;Dermatology;design;Development;Disease;Early identification;Environment;Ethnic Origin;Evolution;Exhibits;experience;extreme prematurity;Failure;feeding;Florida;Future;Genus staphylococcus;Gestational Age;Goals;gut microbes;Hospitalization;Hospitals;Humidity;Incidence;indexing;Infant;innovation;insight;Intervention;K-Series Research Career Programs;Klebsiella;Knowledge;Laboratories;Lactobacillus;large datasets;late onset sepsis;Lead;Leadership;Learning;Life;Medicine;Mentors;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiota transplantation;mortality;Natural History;Neonatal;neonatal sepsis;novel;opportunistic pathogen;Outcome;Outpatients;Parents;pathogen;pathogen exposure;pathogenic bacteria;Pathogenicity;perinatal complications;Physicians;Predisposition;Premature Infant;preterm newborn;Prevention;Prevention strategy;programs;Race;recruit;Research;Research Activity;Research Design;Resources;Risk;Role;Sample Size;Sampling;Science;Scientist;Sepsis;Serratia;sex;Shotguns;Site;skills;Skin;skin barrier;skin microbiome;skin microbiota;skin organogenesis;statistics;Streptococcus;surveillance strategy;Swab;Testing;Therapeutic;Training;Training Activity;Training Programs;Translational Research;Universities;vaginal microbiota;Very Low Birth Weight Infant;Work

PROJECT_TITLE: Characterizing the preterm infant skin microbiome and microbial shifts that precede neonatal late onset sepsis (LOS)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: Seattle

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VIRTICI, LLC

ORG_STATE: WA

PHR: Project Narrative Severe periodontitis affects over 50% of adults worldwide and is characterized by a pathogenic biofilm and chronic inflammation of the tooth supporting tissues11, 27, 72. P. gingivalis is considered a causative species in periodontitis that can function to reshape the oral microbial community leading to dysbiosis and tissue damage73. Development of a safe treatment and preventative for periodontitis that specifically inhibits P. gingivalis colonization without harming the healthy oral microbiome has the potential to significantly improve the health of the world’s population.

PI_NAMEs: FANGER, NEIL A (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acute;Adherence;Adult;Affect;Affinity;Age;Alveolar Bone Loss;Alzheimer's Disease;Amino Acids;Antibiotics;Antigens;aqueous;Arthritis;Bacteria;Binding;Biochemistry;Biological;Biological Assay;bone loss;Cardiovascular Diseases;Chronic;Clinic;Clinical;Clinical Research;Consumption;Cyclic Peptides;Data;Dental;Dental Calculus;Dental Care;Detection;Development;Dose;Drug Kinetics;dysbiosis;Enzyme-Linked Immunosorbent Assay;first-in-human;Formulation;Gingivitis;Goals;Health;Hematology;Hemorrhage;Histopathology;Home;Human;Human Microbiome;improved;In Vitro;Incubated;Infection;Inflammation;inhibitor;innovation;Investments;irritation;liquid chromatography mass spectrometry;Liquid substance;Local Anti-Infective Agents;Malignant Neoplasms;manufacture;Marketing;Mass Spectrum Analysis;Measurement;Measures;Mediating;Methods;Microbial Biofilms;microbial community;microbiome;Minor;Modeling;mouse model;Mouth Sore;Mouthwash;Mus;novel;Operative Surgical Procedures;Oral;Oral Administration;Oral cavity;oral infection;oral microbial community;oral microbiome;Organ;pathogenic bacteria;Pathogenicity;Peptides;Performance;Periodicity;Periodontal Diseases;Periodontitis;Phase;Population;Porphyromonas gingivalis;pre-Investigational New Drug meeting;preservation;prevent;Prevention;procedure cost;Procedures;Recommendation;Recurrence;reduce symptoms;Ribosomal RNA;safety assessment;Saliva;saliva sample;Sampling;Shapes;side effect;Small Business Innovation Research Grant;Solubility;Stains;Streptococcus;Streptococcus gordonii;success;Surface Antigens;Surface Plasmon Resonance;synthetic peptide;Time;Tissues;Tooth Loss;Tooth structure;Toxicology;treatment planning;Virulence;Work;World Health

PROJECT_TITLE: A Novel Peptide for the Oral Treatment and Prevention of P. Gingivalis Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Rural patients have traditionally been underrepresented in cardiovascular clinical trials yet have a higher burden of cardiovascular disease than patients from metropolitan areas. Thus, there is a significant need to integrate rural patients in clinical trials conducted by the Cardiothoracic Surgical Trials Network. Dartmouth- Hitchcock Medical Center and Maine Medical Center as Linked Clinical Research Centers will expand the capacity of cardiothoracic surgery research in Northern New England and develop strategies to implement research findings to rural communities with a high cardiovascular disease burden.

PI_NAMEs: IRIBARNE, ALEXANDER  (contact);KRAMER, ROBERT

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Achievement;Age;Anesthesiology;Area;Atlases;biomedical referral center;burden of illness;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular system;career;career development;Catchment Area;Clinical;Clinical Investigator;clinical practice;Clinical Research;clinical trial recruitment;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;comorbidity;Conduct Clinical Trials;Data;Data Coordinating Center;Dedications;Education;effectiveness/implementation trial;Elderly;Enrollment;Ensure;evidence base;experience;Face;Faculty;Funding;Future;geographic difference;Goals;Health Policy;Home;Hospitals;implementation evaluation;implementation research;implementation science;improved;Incidence;Individual;International;Knowledge;Life Expectancy;Link;Maine;Medical center;medical specialties;medically underserved;Medicare;Medicare claim;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;metropolitan;Mission;Network Infrastructure;Neurology;New England;next generation;Operative Surgical Procedures;patient population;Patient Recruitments;Patients;Population;population health;Population Research;process evaluation;programs;prospective;Public Health;Recording of previous events;recruit;Registries;repository;Research;research and development;Research Infrastructure;Research Personnel;Role;Rural;Rural Community;Rural Health;rural patients;Rural Population;Scholars Program;Scientist;skills;socioeconomics;success;surgery outcome;surgical research;Teleconferences;Training;Translational Research;trial design;Underrepresented Populations;Visit;Work

PROJECT_TITLE: Advancing Cardiothoracic Surgical Trials in Rural Health Populations


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Newburyport

ORG_NAME: ENCLEAR THERAPIES, INC.

ORG_STATE: MA

PHR: Project Narrative Leptomeningeal disease (LMD) is a metastatic cancer of the brain that impacts up to 30% of all patients with a primary tumor of advanced stage, most commonly from breast, lung or skin cancer. Treatment options and prognosis for these patients are poor with survival ranging from 3-6 months depending on the location of the primary tumor. The device proposed in this project will deliver chemotherapy more effectively by controlling the flow of CSF in an effort to improve patient outcomes.

PI_NAMEs: GLICKSMAN, MARCIE A (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Address;Algorithms;Anatomy;Anesthesia procedures;Animal Diseases;animal efficacy;Animal Model;animal safety;Animals;Arachnoid Membrane;Area;awake;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain Neoplasms;Breathing;cancer cell;Cancer Model;Categories;Catheters;Cerebral Dominance;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrospinal Fluid Pressure;chemotherapy;Circulation;comparison control;Data;design;design verification;Development;Devices;Diffuse;Diffusion;Disease;Disseminated Malignant Neoplasm;Dose;drug distribution;Drug or chemical Tissue Distribution;efficacy study;Engineering;Family suidae;first-in-human;Freezing;Frequencies;Glioma;Grant;Heart;Hour;Human;human study;Image;Immunocompetent;improved;innovation;interest;intravenous administration;Laws;Legal patent;Lentivirus;Leptomeninges;Location;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of lung;Measurement;Measures;Methodology;Methotrexate;Miniature Swine;Modeling;Movement;Neoplasm Circulating Cells;Neurologic;nonhuman primate;Patient Monitoring System;patient prognosis;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiologic intraventricular pressure;Physiological;pre-clinical;Preclinical Testing;pressure;pressure sensor;Primary Neoplasm;Procedures;Process;Prognosis;prototype;Pump;Reporting;respiratory;response;risk mitigation;Rodent Model;Safety;safety and feasibility;safety study;sensor;Series;Sheep;sheep model;Signal Transduction;Skin Cancer;Small Business Innovation Research Grant;Spinal Cord;Spinal nerve root structure;standard of care;Structure;Subarachnoid Space;Surface;System;technology platform;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Topotecan;Toxicology;tumor;Tumor Burden;Work

PROJECT_TITLE: Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: PROTON BIO, INC.

ORG_STATE: MD

PHR: Glioblastoma (GBM) aggressively spreads to surrounding brain tissue, often preventing surgical resection; approved therapy works in only 30% of patients. Our results with genetic and pharmacological GPR68 knockdown suggest GPR68 is critical for GBM survival and treatment resistance, and this Phase I project is focused on selecting a lead GPR68 inhibitor and establishing proof-of-concept that GPR68 is a therapeutically relevant and tractable target. Successful completion of this project will move us closer to developing a new therapy that could finally make a significant shift in GBM patient survival.

PI_NAMEs: WILLIAMS, CHARLES HOUSTON (contact)

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Adult;aggressive therapy;analog;Analysis of Variance;Autopsy;Binding Proteins;Biological Assay;Biological Availability;Blood;Body Weight;Brain;Brain Neoplasms;brain tissue;Cancer Biology;Cell Death;Cell Survival;Cells;Characteristics;Chemoresistance;Clinic;clinical development;Communication;Creativeness;Cytochrome P450;Data;Development;Dialysis procedure;Disease Resistance;Dose;Drug Kinetics;efficacy study;Environment;Equilibrium;Evaluation;Excision;extracellular;Female;Foundations;Funding;G-Protein-Coupled Receptors;Genetic;Glial Fibrillary Acidic Protein;Glioblastoma;Goals;GPR68 gene;Histologic;Histology;Human;Immunohistochemistry;improved;In Vitro;in vivo;Industry Standard;inhibitor;Investigational New Drug Application;Iron;knock-down;Lead;lead candidate;lead optimization;Liver Microsomes;Magnetic Resonance Imaging;male;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;meter;Microsomes;Monitor;Mouse Strains;multidisciplinary;Mus;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Operative Surgical Procedures;Oral;Oral Administration;Organ;Paper;Parents;patch clamp;patient derived xenograft model;Patients;Penetration;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phenotype;Plasma;Plasma Proteins;preclinical development;preclinical study;prevent;Process;Property;Protein Isoforms;Protons;R7 Virus;Radiation;Randomized;Regimen;Relapse;Research;Resistance;Resources;response;Side;Small Business Innovation Research Grant;small molecule;standard of care;Structure-Activity Relationship;Survival Rate;temozolomide;Testing;Therapeutic;therapeutic target;therapy resistant;three dimensional cell culture;Time;Toxic effect;treatment effect;treatment group;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;Validation;Work;Zebrafish

PROJECT_TITLE: Targeting proton-sensing GPR68 as a ferroptosis-based therapy for glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-T (10)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRRATIVE Acute pancreatitis is a common gastrointestinal disease that can rapidly progress to life-threatening severe pancreatitis (SAP). We propose the MoSAIC study to better understand the mechanisms of SAP and develop a blood test that identifies which patients will progress to SAP during hospitalization.

PI_NAMEs: LACY-HULBERT, ADAM ;PAPACHRISTOU, GEORGIOS I (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Academic Medical Centers;acute pancreatitis;Admission activity;Ancillary Study;Angiopoietin-2;Automobile Driving;Bioinformatics;Blood specimen;Blood Tests;Blood Urea Nitrogen;Body System;cell type;Cells;Clinical;clinical research site;Clinical Trials;clinically relevant;cohort;Communities;cost;cytokine;Cytometry;Dedications;design;Development;Disease;Educational workshop;Enrollment;ethnic diversity;Event;Frequencies;Functional impairment;Funding;Future;Gastrointestinal Diseases;Gene Expression Profile;Grant;Helper-Inducer T-Lymphocyte;HGF gene;high dimensionality;Hospitalization;Hospitals;Hour;Human;human data;Immune;Immune Targeting;Immunologics;Immunologist;Immunology;Immunotherapeutic agent;Immunotherapy;In Vitro;Inflammatory Response;insight;Insulin-Dependent Diabetes Mellitus;Intensive Care Units;Interleukin-8;Intervention;Knowledge;Length of Stay;Life;Measures;member;Memory B-Lymphocyte;Methods;monocyte;mosaic;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;Ohio;Organ failure;Outcome;Pancreatitis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Phenotype;Pilot Projects;point of care testing;Population;Population Heterogeneity;predictive panel;predictive tools;Process;prospective;Publishing;receptor;Records;Research;Research Institute;Research Personnel;resistin;Serum;Severity of illness;Systemic Inflammatory Response Syndrome;T-Cell Activation;Testing;Therapeutic Agents;therapeutic target;Time;time of flight mass spectrometry;Time trend;time use;TNF gene;TNFRSF1A gene;transcriptome sequencing;United States National Institutes of Health;Universities;Whole Blood;Work

PROJECT_TITLE: Immune Signatures and Clinical Outcomes in Acute Pancreatitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Cardiovascular events (heart damage, stroke, blood clots) appear to be both common and dangerous in patients who are hospitalized with COVID-19. A better understanding of which patients are at highest risk for these events is a key step to developing better approaches for prevention and treatment. We will combine multiple sources of information, including a large national COVID-19 registry from the American Heart Association, health care data from Medicare, and blood protein levels from patients treated at Beth Israel Deaconess Medical Center, to identify the factors that are associated with a higher risk of short- and long-term cardiovascular events among patients hospitalized with COVID-19.

PI_NAMEs: GERSZTEN, ROBERT E;KAZI, DHRUV SATISH;YEH, ROBERT  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acceleration;Address;Admission activity;Adult;Affect;American Heart Association;biobank;Biochemical;Biochemical Markers;Biological;Biological Markers;biomarker discovery;Blood coagulation;Blood Proteins;Blood specimen;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;care delivery;Cessation of life;Characteristics;Clinical;Clinical Management;clinical phenotype;clinical predictors;clinical risk;cohort;Communities;Comprehensive Health Care;COVID-19;COVID-19 patient;COVID-19 risk;COVID-19 sequelae;Dangerousness;Data;Data Linkages;data resource;Deep Vein Thrombosis;deprivation;Development;Dimensions;Disease;disease registry;economic indicator;effective therapy;Embolism;Event;experience;Future;Geography;Health;Health system;Healthcare;Heart Arrest;heart damage;Heart failure;high risk;Hospitalization;Hospitals;improved;indexing;insight;Institution;Israel;Link;Longterm Follow-up;Lung;Machine Learning;Measures;Medical;Medical center;medical information system;Medicare;Medicare claim;model generalizability;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;Myocarditis;older adult;older patient;Outcome;pandemic disease;Pathology;Patient Care;Patient risk;patient subsets;Patient-Focused Outcomes;Patients;personalized care;personalized management;Predictive Factor;predictive marker;predictive modeling;Prevention approach;prognostic;Proteins;Proteomics;Registries;Research;Risk;Risk Factors;risk prediction;rurality;SARS-CoV-2 infection;Site;Socioeconomic Factors;socioeconomics;Source;Standardization;Stroke;Time;Ventricular Arrhythmia;Work

PROJECT_TITLE: A Multi-Dimensional Linked Registry to Identify Biological, Clinical, Health System, and Socioeconomic Risk Factors for COVID-19-Related Cardiovascular Events

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Eye Disease and Disorders of Vision;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MEMPHIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Glaucoma is the second leading cause of blindness worldwide. Current demographic, ocular, imaging, or genetic factors alone are insufficient to predict the risk of glaucoma accurately. We propose to develop artificial intelligence tools to identify individuals at-risk of developing glaucoma and future vision loss.

PI_NAMEs: YOUSEFI, SIAMAK  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Affect;aging population;Anatomy;archetypal analysis;Artificial Intelligence;artificial intelligence model;Atlases;Axon;Blindness;care burden;Caring;Clinical;clinical care;clinical practice;Clinical Trials;clinically relevant;Complex;Country;Cox Proportional Hazards Models;Data;deep learning;deep learning model;demographics;Developing Countries;Development;Diagnosis;Disease;endophenotype;Evaluation;experience;Eye;field study;Functional disorder;Fundus;Future;Genetic;Genetic Markers;genome wide association study;Glaucoma;Growth;Hereditary Disease;High Prevalence;high risk;hypertension treatment;Image;improved;Incidence;Individual;Machine Learning;machine learning model;Maps;Modality;Modeling;multimodality;Nerve Degeneration;novel;novel marker;Ocular Hypertension;older adult;Older Population;Ophthalmologist;Optic Disk;optical disc;Outcome;Participant;Patients;Pattern;Persons;Phenotype;Population;population based;Populations at Risk;predictive modeling;Prevalence;prevent;Primary Open Angle Glaucoma;Resolution;Resources;Retina;retinal ganglion cell degeneration;retinal nerve fiber layer;Risk;Risk Factors;risk prediction;screening;Screening procedure;Side;sight restoration;Single Nucleotide Polymorphism;Specific qualifier value;statistical and machine learning;statistical learning;Surrogate Endpoint;Testing;tool;usability;Validation;Visual Fields;Work

PROJECT_TITLE: Predicting the risk of glaucoma from structural, functional, and genetic factors using artificial intelligence

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative Generalized spike-wave (SW) absence seizure is the most common seizure disorder in children and thought to be exclusively of genetic origin. While over 20 genes have been discovered and studied in SW epilepsies, it re- mains unclear how each of genetic lesions disrupts the stability of developing cortical circuits and ultimately leads to the same seizure phenotype. To this end, we take advantage of three monogenic mouse models of SW epilepsy and perform the comprehensive cortical circuit analysis and comparisons among distinct genotypes along the seizure development, aiming to identifying the stereotypical circuit deficits underlying SW seizure expression.

PI_NAMEs: JIANG, XIAOLONG  (contact);NOEBELS, JEFFREY

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Absence Epilepsy;Affect;Animal Model;Behavior;Behavioral;Biological Assay;Brain;cell type;Cells;Cerebral cortex;Child;Clear Cell;cognitive function;comorbidity;cost;Data;Defect;Development;Disease;Disparate;Electrophysiology (science);Epilepsy;gene discovery;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genotype;Impaired cognition;Impairment;in silico;in vivo;Inherited;innovation;insight;Interneurons;Intervention;Lesion;Measures;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;network models;neural;neural circuit;neural network;neurodevelopment;Neurons;novel;Parvalbumins;Pathogenicity;Pathologic;Patients;Pattern;Persons;Phenotype;Property;Recurrence;Role;Seizures;Societies;Somatosensory Cortex;Somatostatin;Stereotyping;Structure;System;Testing;therapeutic target;Time;United States

PROJECT_TITLE: Development of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: RENO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Slit is a signaling molecule that repels growing nerves. Slit can get cut into two fragments that have new and distinct activities, both for growing nerves and many other processes in the body including inhibiting HIV replication, metabolic function and blood vessel permeability. Despite this, the function of Slit fragments in nerve growth is controversial and this proposal will define the biological activities of the fragments using a molecular genetic approach in vivo.

PI_NAMEs: KIDD, THOMAS  (contact);MASTICK, GRANT STEPHEN

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adhesions;Affect;Alleles;Antibodies;Axon;axon growth;axon guidance;Binding Sites;Biological;Biological Assay;Biological Process;Blood Vessels;Brain;Cell Adhesion;Cell Culture Techniques;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Cues;Data;design;Development;Drosophila genus;Embryo;Experimental Models;experimental study;fly;genetic approach;genetic testing;Goals;Growth;HIV;In Vitro;in vivo;in vivo evaluation;inhibitor;Knock-out;Length;Ligands;Malignant Neoplasms;Mediating;Metabolic;Molecular;Molecular Genetics;Mus;Muscle fasciculation;mutant;Nerve;Nerve Regeneration;Nervous System;nervous system development;neurodevelopment;Neurons;novel;Outcome;Output;Peptide Hydrolases;Permeability;Phenotype;Physiological;Principal Investigator;Process;Production;programs;Protein Secretion;Proteins;Proteolytic Processing;Reagent;receptor;receptor binding;Recombinant Proteins;response;Role;Sensory;Signal Transduction;Signaling Molecule;System;Testing;Tissues;tool;Transgenic Organisms;Work

PROJECT_TITLE: Slit Fragments Generate Diversity in Axon Guidance Signals

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE A vast and diverse community of microbes known as the gut microbiota colonizes the human intestine. The microbiota is largely a beneficial community, but also produces some potentially toxic compounds that can accumulate to high levels in the circulation of dialysis patients. This proposal aims to define the bacterial species and genes that make these compounds and how the gut microbiota can be rationally altered to reduce the production of toxic substances.

PI_NAMEs: FISCHBACH, MICHAEL ANDREW;MEYER, TIMOTHY W;SONNENBURG, JUSTIN L (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Ablation;absorption;Acids;Affect;Amino Acids;Anabolism;analysis pipeline;Animal Model;Antibiotics;Area;Bacteria;Behavioral;Biochemical Pathway;Biological;Biology;Circulation;cognitive function;Colon;colon microbiota;Communities;comparative genomics;Complex;computerized tools;Cresol;Data;Data Set;design;Dialysis patients;Dialysis procedure;Diet;Diet Modification;dietary;Ecosystem;Enzymes;Excretory function;experimental study;Foundations;frontier;Gene Deletion;Genes;Genetic;Gnotobiotic;Goals;Grant;gut microbiome;gut microbiota;Health;Human;human data;human subject;improved outcome;Individual;Individual Differences;individual patient;Individuality;Infrastructure;Intervention;Intestines;Investigation;Isotope Labeling;Kidney;Kidney Diseases;Knowledge;Libraries;Link;Machine Learning;member;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methods;Microbe;microbial;microbial community;microbiome;microbiota;microbiota composition;microbiota metabolites;Molecular;Molecular Genetics;Mus;mutant;novel;novel strategies;Output;Patient-Focused Outcomes;Patients;Persons;Phase;Phenotype;Plasma;Poison;poor health outcome;Process;Production;programs;reconstitution;Renal function;Research;Research Design;Role;Series;solute;Source;Sulfate;Taxonomy;Testing;Thrombosis;Time;tool;translation to humans;Translations;Tyrosine;Uremia;Urine;Work

PROJECT_TITLE: Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Illegitimate DNA double-strand break (DSB) repair fuels genomic instability and subsequent tumorigenic transformation. The goal of this program is to understand how the nature of DNA lesions, their chromatin context, cell type and cell cycle phase in which they arise influence their pathological outcomes: mutations and chromosome rearrangements.

PI_NAMEs: GAUTIER, JEAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Actins;Affect;ATM deficient;Automobile Driving;Biochemistry;BRCA1 gene;cancer genome;cancer type;Cell Cycle;Cell Cycle Stage;Cell Nucleus;cell type;Cellular biology;chemotherapeutic agent;chemotherapy;Chromatin;Chromosomal Rearrangement;Chromosomal translocation;Chromosomes;clinically relevant;Collaborations;Complex;Computational Biology;Computer Analysis;Data;Defect;Development;DNA;DNA Adducts;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Sequence;DNA Topoisomerases;Double Strand Break Repair;Etiology;Excision;experimental analysis;Funding;Genes;Genetic;Genome;genome editing;Genomic approach;Genomic Instability;Genomic Segment;Genomics;genotoxicity;Goals;Human;Immunoglobulins;in vivo;Lesion;Lymphocyte;Lymphoma;Malignant Neoplasms;Mammalian Cell;Maps;Molecular Analysis;mouse model;Mutate;Mutation;Mutation Analysis;Nature;next generation;Nuclear;Outcome;Pathogenicity;Pathologic;Pathway interactions;Pattern;Phase;Phosphotransferases;Physiological;Poisoning;Process;Productivity;programs;Proteins;Recording of previous events;repaired;Repetitive Sequence;Replication Error;response;Ribosomal DNA;Signal Pathway;Signal Transduction;Single-Stranded DNA;Source;stressor;T-Cell Receptor;Technology;telomere;Topoisomerase;Topoisomerase Inhibitors;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Wiskott-Aldrich Syndrome;Yeast Model System;Yeasts

PROJECT_TITLE: DNA double-strand break repair, chromosome translocations and cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

PHR: PROJECT NARRATIVE: Genomic instability, a major driving force of cancer initiation and progression, generates unique “mutation signatures” that are characteristic of specific types of human cancer. To elucidate how these mutation signatures arise during tumor development, this study will focus on triple-negative breast cancer (TNBC), a highly aggressive malignancy characterized by lesions in the BRCA1 tumor suppression pathway. In particular, the full spectrum of TNBC mutation signatures will be defined and the molecular mechanisms by which these signatures arise will be elucidated.

PI_NAMEs: RABADAN, RAUL  (contact)

PROJECT_TERMS: Ablation;Address;Automobile Driving;BARD1 gene;base;Biological;Biology;blind;brca gene;BRCA mutations;BRCA1 gene;BRCA1 Mutation;Breast Cancer Patient;cancer genome;cancer initiation;cancer subtypes;Cells;Characteristics;Chromosomal translocation;Complex;Computer Analysis;computer framework;de novo mutation;Defect;Development;DNA;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Gene;Double Strand Break Repair;driving force;Family;Foundations;Genes;Genome;genome integrity;Genome Stability;genomic data;Genomic Instability;Genomics;genotoxicity;Germ Lines;Hereditary Breast Carcinoma;Human;human data;Impairment;improved;in vivo;Lesion;Link;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Methods;Methylation;Missense Mutation;Molecular;Molecular Biology;mouse model;Mus;mutant;Mutate;Mutation;novel;PARP inhibition;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;preservation;Process;promoter;Proteins;repaired;Risk Assessment;Series;Source;Techniques;Testing;triple-negative invasive breast carcinoma;tumor;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Variant;whole genome

PROJECT_TITLE: Project 1 Rabadan


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Infectious Diseases;Sepsis

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative  Sepsis is a highly lethal disorder due of uncontrolled infection. It is the major cause of death in most intensive care units in the United States. This program seeks to identify molecular mechanisms of immune suppression and discover new immune-based therapies that will boost patient immunity and thereby increase the ability of the patient to eradicate the infecting organisms and survive.

PI_NAMEs: HOTCHKISS, RICHARD SAMUEL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: adaptive immunity;aged;aging population;Animals;Cause of Death;Cessation of life;Clinical Trials;cytokine;Cytomegalovirus;Data;Disease;Failure;Functional disorder;Goals;immune modulating agents;Immune system;Immunity;Immunologic Adjuvants;Immunologic Tests;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;Incidence;Infection;Inflammatory;Inflammatory Response;Intensive Care Units;Investigation;Life;Mediating;Molecular;Morbidity - disease rate;mortality;Natural Immunity;Nosocomial Infections;opportunistic pathogen;Organ;organ injury;Organism;Patients;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Primary Infection;Principal Investigator;programs;Research;Safety;Sepsis;Simplexvirus;Translations;Treatment Protocols;United States;Virus Latency

PROJECT_TITLE: Enhancing Innate and Adaptive Immunity to Improve Sepsis Survival


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Kinase inhibitors are gaining increased FDA approvals for treatment of cancer and other diseases. This proposal seeks to apply new computational protocols based on cutting-edge molecular simulation and quantum calculation tools to tackle several critical topics in the rational design of reversible and targeted covalent inhibitors of kinases. Outcome of the studies will accelerate the kinase drug discovery efforts and expand the druggable target space.

PI_NAMEs: SHEN, JANA  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Affinity;Amber;Area;Attenuated;Autoimmune;base;Binding;cancer therapy;Chemicals;Collaborations;computational platform;computerized tools;Coupling;Data;Databases;design;Development;Disease;Drug Design;drug discovery;druggable target;Free Energy;Goals;Imatinib;improved;Inflammatory;inhibitor;insight;kinase inhibitor;Kinetics;Knowledge;Letters;Link;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;new therapeutic target;novel;Oncogenic;Opioid Receptor;Outcome Study;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Pilot Projects;Process;prospective;protein protein interaction;Proteins;Proteome;Protocols documentation;Protons;quantum;rapid growth;rational design;Reaction;residence;Scanning;simulation;Site;small molecule;Solvents;Speed;Structure;Testing;therapeutic target;Time;Titrations;tool;tool development;Toxic effect;ubiquitin-protein ligase;Validation;Work

PROJECT_TITLE: A Multi-pronged Computational Approach to Advance Kinase Drug Discovery

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

PHR: NARRATIVE A driving force behind tumorigenic transformation is genomic instability that can result from defects in the cellular mechanisms to repair DNA damage. In this proposal we seek to understand how DNA damage generates genome instability, and we will identify the DNA repair proteins that protect the genome by preventing chromosome rearrangements.

PI_NAMEs: SYMINGTON, LORRAINE S (contact)

PROJECT_TERMS: Address;Aneuploidy;ANGPTL2 gene;base;Biological Assay;BRCA1 gene;cancer cell;cancer genome;Cell Survival;Cells;Chromosomal Breaks;Chromosomal Rearrangement;Chromosomal translocation;Chromosomes;clastogen;Collaborations;Complex;CRISPR/Cas technology;Defect;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;DNA Sequence;Double Strand Break Repair;driving force;endonuclease;Event;Excision;Exhibits;experimental study;Frequencies;Functional disorder;Gene Family;Genes;Genetic;Genetic Screening;Genome;Genomic Instability;Human;Individual;insertion/deletion mutation;Knowledge;Left;Lesion;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Methods;Mutagenesis;mutant;Mutation;Nature;next generation sequencing;Nonhomologous DNA End Joining;novel;nuclease;Outcome;Pathology;Pathway interactions;prevent;Process;Proteins;repaired;Replication Error;replication stress;Resected;response;Role;Signal Pathway;Site;Source;System;Technology;telomere;tumor;tumor DNA;tumorigenic;Yeasts

PROJECT_TITLE: Project 2 Symington


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Atrial fibrillation (AF) is the most common cardiac arrhythmia and is a common cause of stroke. We have identified a molecule (PPP1R12C) that contributes to atrial heart muscle dysfunction and increases risk of AF. Our project will intervene on this molecule to determine its role in heart disease and stroke, and will validate therapeutic approaches to reduce stroke risk from AF.

PI_NAMEs: MCCAULEY, MARK D (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Angiotensin II;Angiotensin Receptor;Anticoagulants;Arrhythmia;Atrial Fibrillation;Attenuated;auricular appendage;Binding;Biological Assay;Blood;Breeding;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Catalytic Domain;Cause of Death;Chronic;Data;Endothelium;Event;Exclusion;Functional disorder;Genetic;Genetic Transcription;Goals;Heart;Heart Atrium;Heart Diseases;Holoenzymes;Human;In Vitro;in vivo;inhibitor;innovation;insight;Intervention;Knock-out;Knockout Mice;Knowledge;Limb structure;Measures;Methods;Microfilaments;mouse model;Mus;Mutant Strains Mice;Myocardium;Myosin ATPase;Myosin Light Chains;Oral;Osmosis;Outcome;overexpression;Pathologic;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Population;Predisposition;prevent;prophylactic;Prophylactic treatment;Protein Dephosphorylation;protein expression;Protein Inhibition;Protein Overexpression;Protein phosphatase;Proteins;Pump;Reporter Genes;Risk;Role;Saline;Sarcomeres;Signal Transduction;Stroke;Stroke prevention;stroke risk;Structural Protein;Testing;Therapeutic;therapeutic development;thromboembolic stroke;Thrombophilia;Thrombosis;Time;transcription factor;Validation;valsartan

PROJECT_TITLE: Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial Fibrillation

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE  Our proposed study 1) addresses the molecular mechanisms by which DNA damage responses affect the substitution and translocation signatures during lymphomagenesis, 2) identifies the impact of cell cycle phases on the DNA damage induced accessibility changes and the translocation patterns, and 3) elucidates the translocation outcomes of different type of breaks – clean breaks, RAG or AID initiated physiological break in antigen receptor genes, and Top1-cc like lesions.

PI_NAMEs: ZHA, SHAN  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Antigen Receptors;ATAC-seq;ATM deficient;B-Lymphocytes;Beak;Binding;BRCA1 gene;cancer type;Cell Cycle;Cell Proliferation;cell type;Cells;Chromatin;Chromosomal Rearrangement;Chromosomal translocation;Collaborations;Complex;density;Development;Distant;DNA;DNA Damage;DNA Double Strand Break;Double Strand Break Repair;ds-DNA;endonuclease;Etiology;Excision;experience;Frequencies;Funding;G1 Arrest;gene product;Genetic Recombination;Genetic Transcription;Genome;genome-wide;Genomic Instability;genomic signature;Genomics;H2AFX gene;Heterogeneity;Human;Human Genome;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunoglobulins;Inbred Mouse;Lesion;leukemia/lymphoma;Link;Lymphocyte;lymphoid neoplasm;Lymphoma;Lymphomagenesis;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Modification;Molecular;Monitor;mouse model;Nucleosomes;Null Lymphocytes;Oncogenic;Organ;Outcome;p53-binding protein 1;Pathogenicity;Pattern;Phase;Phosphorylation;Physiological;Proliferating;Proto-Oncogenes;Receptor Gene;recruit;Recurrence;Regulation;repaired;replication stress;response;Risk;RNA;Role;Sequence Analysis;T-Cell Lymphoma;T-Cell Receptor;Testing;Tissues;Tn5 transposase;Transposase;Tumor Suppressor Genes;Tumor Suppressor Proteins;V(D)J Recombination

PROJECT_TITLE: Project 3 Zha


NIH_SPENDING_CATS: Hematology

ORG_NAME: DANA-FARBER CANCER INST

PHR: Our work has identified the protein NCOA4 as a critical regulator of iron homeostasis in health and disease. NCOA4 targets ferritin, the cellular iron storage complex, for degradation in the lysosome which leads to release of iron for use in a variety of physiological pathways, e.g. DNA replication and repair, hemoglobin synthesis, and red blood cell production. This proposal focuses on identifying how NCOA4 activity is regulated in cells and the importance of NCOA4 in normal physiology and in pathophysiological conditions such as iron deficiency anemia and ferroptosis, an iron-dependent form of cell death. A further understanding of how NCOA4 works could improve treatment of iron deficiency disorders such as iron deficiency anemia and iron overload disorders such as hemochromatosis.

PI_NAMEs: MANCIAS, JOSEPH D (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acute;Affect;Autophagocytosis;Autophagosome;Binding;Biochemical;Biological;Biological Availability;Biological Models;Cell Culture System;Cell Culture Techniques;Cell Death;Cell model;Cell Nucleus;Cells;chelation;Complex;CRISPR/Cas technology;Cytoplasm;Cytoprotection;Data;Dependence;deprivation;Disease;DNA biosynthesis;DNA Repair;Elements;Equilibrium;Erythrocytes;Erythropoiesis;ferrihydrite;Ferritin;FTH1 gene;Functional disorder;Generations;genome editing;Health;Heme;Hemochromatosis;Hemoglobin;Homeostasis;human disease;improved;In Vitro;in vivo;Injury to Kidney;insight;Iron;iron deficiency;Iron deficiency anemia;iron metabolism;Iron Overload;Iron-Regulatory Proteins;Ischemia;Knock-out;Life;Light;Link;Lipid Peroxidation;liver injury;Lysosomes;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;microcytic/hypochromic anemia;Minerals;Mitochondria;Modeling;Molecular;mouse model;Mus;mutant;novel;Nuclear Protein;Nuclear Receptor Coactivator 4;overexpression;Oxygen;Pancreatic Ductal Adenocarcinoma;Pathologic;Pathway interactions;Physiological;Physiological Processes;Physiology;Process;Production;protein complex;Proteins;Proteomics;proteostasis;Reactive Oxygen Species;receptor;Regulation;renal ischemia;Reperfusion Injury;Reporting;response;Role;Therapeutic;therapeutic target;Tissues;tool;trafficking;ubiquitin-protein ligase;Work;Zebrafish

PROJECT_TITLE: The role of NCOA4-mediated ferritinophagy in iron homeostasis and ferroptosis

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


PHR: PROJECT NARRATIVE Aberrant chromosome rearrangements, particularly chromosome translocations, are implicated in the development of human cancers. Chromosomal translocations arise when DNA breaks are inappropriately brought in close vicinity and mis-repaired. Thus, the generation of distinct repair domains is a critical tumor suppressor mechanism. The goals of this project are to determine how DNA double-strand breaks domains are generated to ensure genome stability and how defects in the spatial organization of DSB repair yields specific mutation and chromosome rearrangement signatures.

PROJECT_TERMS: 3-Dimensional;Actins;Address;adduct;Affect;ANGPTL2 gene;Binding;Biological Assay;cancer genome;Cell Nucleus;Cells;Chromatin;Chromosomal translocation;Chromosome abnormality;chromosome conformation capture;chromosome movement;Chromosomes;Clinic;Clinical;clinically relevant;Collaborations;Complex;Data;Defect;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Replication Induction;DNA Topoisomerases;Double Strand Break Repair;endonuclease;Ensure;Eukaryotic Cell;Event;Excision;Exhibits;experimental study;G2 Phase;gain of function;gain of function mutation;Generations;Genes;Genetic Transcription;Genome;genome sequencing;Genome Stability;genome-wide;Genomic Instability;Genomics;Goals;Hi-C;Human;inhibitor;Link;loss of function;Maintenance;Malignant Neoplasms;Mammalian Cell;Microscopy;migration;Mobility decline;Monitor;Motion;Movement;mutant;Mutate;Mutation;Neutropenia;Nonhomologous DNA End Joining;novel;Nuclear;nuclease;Pathogenicity;Pathologic;Pathway interactions;Patients;polymerization;Polymers;prevent;programs;Reaction;recruit;repaired;Role;S phase;Severities;Shapes;stressor;telomere;Testing;tool;Topoisomerase Inhibitors;tumor;Tumor Suppression;Tumor Suppressor Proteins;whole genome;Wiskott-Aldrich Syndrome;Xenopus laevis;Yeasts

PROJECT_TITLE: Project 4 Gautier


NIH_SPENDING_CATS: Cancer;Genetics

PROJECT_TERMS: Administrator;Appointment;Area;Budgets;Cancer Center;Chromosomal translocation;Communication;conflict resolution;Data;data management;data sharing;DNA Double Strand Break;Double Strand Break Repair;Ensure;Evaluation;Feedback;Future;Goals;Herbert Irving Comprehensive Cancer Center;Human Resources;Individual;Laboratories;Laboratory Personnel;Leadership;Malignant Neoplasms;meetings;member;Mission;Monitor;operation;Organization administrative structures;Participant;Policies;Preparation;Procedures;Program Reviews;programs;Progress Reports;recruit;Research;Research Personnel;Research Support;Resource Allocation;Resource Sharing;Resources;Salaries and Fringe Benefits;Scientist;Services;Structure;success;synergism;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Admin CORE Gautier


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our study will significantly advance our understanding of the life course exposures from gestation to adulthood that shape microbiome markers of inflammaging and DNA methylation aging. This is crucial because identifying microbiome markers of biological aging in adulthood will allow us to better identify signs of early aging via the microbiome.

PI_NAMEs: AIELLO, ALLISON E;HARRIS, KATHLEEN MULLAN;KRAUTER, KENNETH S (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Adolescent;Adult;Age;age related;age related biomarkers;age-related disease;Aging;aging biomarker;aging clocks;Animal Model;beta diversity;Biological Aging;Biological Factors;Biological Markers;Biology;Biology of Aging;Breast Feeding;C-reactive protein;Collection;Communities;Data;Data Collection;data dissemination;Diet;DNA Markers;DNA Methylation;Documentation;early life exposure;Elasticity;Ethnic Origin;Etiology;Gene Expression;genomic biomarker;Geography;Germ-Free;gut microbes;gut microbiome;gut microbiota;Health;Health behavior;Human;human microbiota;human old age (65+);Immigrant;Immune;Immune system;Immunity;Individual;Individual Differences;Inflammaging;Inflammation;Inflammatory;inflammatory marker;innovation;Intake;Interleukin-10;Interleukin-6;Intervention;Life;Life Cycle Stages;Longitudinal cohort;Longitudinal Studies;Measures;Methods;microbial;microbiome;microbiome research;middle age;Mus;National Longitudinal Survey of Adolescent to Adult Health;novel;Oral Characters;oral microbiome;Participant;Pharmaceutical Preparations;phenotypic biomarker;Phylogenetic Analysis;Population;Pregnancy;Process;Protocols documentation;Race;Research;Research Personnel;Resources;Respondent;response;Role;Sampling;Shapes;Social Environment;social factors;Socioeconomic Status;socioeconomics;Source;stool sample;stressor;Subgroup;Surveys;Taxon;Testing;Time;TNF gene;Tongue;Weight

PROJECT_TITLE: The Microbiome and Biological Aging in the Add Health Study

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Norovirus is the leading cause of childhood diarrhea around the world, but the development of therapeutics has been limited by a lack of understanding of the pathogenic mechanisms underlying norovirus-induced gastroenteritis. We have developed a symptomatic mouse model for murine norovirus infection that allows us to study how norovirus causes disease. The objectives of this proposal are to understand norovirus interactions with the intestinal epithelium and how these norovirus-intestinal epithelium interactions cause diarrhea.

PI_NAMEs: PEIPER, AMY MARIE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acids;Acute;Adult;age group;Animal Model;Anti-viral Agents;Anti-viral Therapy;Antigen-Presenting Cells;ASBT protein;Bile Acids;Binding;Biological Models;Biology;Biopsy;burden of illness;career;Cells;cellular targeting;Cessation of life;Childhood;Complex;Data;Dendrites;Detection;Development;Diarrhea;Disease;efficacy testing;Enteral;Enterohepatic Circulation;Epithelial Cells;Epithelium;Fellowship;Gastroenteritis;Goals;Health;Human;ileum;Immune;Immune Targeting;Immunocompetent;Immunocompromised Host;improved;in vivo;Infection;Ingestion;Intestinal Diseases;intestinal epithelium;intestinal villi;Intestines;Kinetics;Lamina Propria;Liver;Mentors;Modeling;mortality;mouse model;Movement;Mus;neonatal mice;Norovirus;novel;pathogen;Pathogenesis;Pathogenicity;Pattern;Peyer's Patches;Physicians;Population;Preventive treatment;pup;receptor;Reporter;Research;Role;Route;Scientist;Severity of illness;Symptoms;targeted treatment;Testing;therapeutic development;Time;Training;transcytosis;Tropism;uptake;Vaccines;Villous;Viral;Virion;virology;Virus;Virus Diseases;Virus Receptors;Virus Replication;Work

PROJECT_TITLE: The Role of Norovirus Interactions with the Epithelial Barrier in Acute Gastroenteritis


PHR: NARRATIVE The Molecular Analysis of Genomic Instability Core will perform state-of-the-art assays for program investigators in the analyses of chromosome aberrations, and the cellular response to DNA damage. Having a dedicated core for this program is beneficial: 1) for cost effectiveness and 2) for custom designing the experiments based on specific requirement for each of the projects. By centralizing these services under the leadership of two experienced investigators, Drs. Lorraine Symington and Shan Zha, the Core will enhance the productivity of the program project members by providing essential and customized services to all projects, and ensure uniformity of data acquisition and interpretation.

PROJECT_TERMS: Biological Assay;Cell Line;Cells;Chromosomal Breaks;Chromosomal translocation;Chromosome abnormality;clastogen;Clonal Expansion;Complement;cost effectiveness;Custom;Cytogenetic Analysis;Cytogenetics;data acquisition;Data Analyses;Dedications;detection assay;DNA;DNA Damage;DNA Double Strand Break;DNA Markers;DNA Repair;DNA Repair Pathway;DNA Sequence Rearrangement;DNA sequencing;Double Strand Break Repair;Ensure;Excision;experience;Experimental Designs;G-Banding;Gamma-H2AX;Genomic approach;Genomic Instability;Human;Image;irradiation;Karyotype determination procedure;Leadership;Length;Malignant Neoplasms;Mammalian Cell;Measures;member;Methods;Molecular Analysis;Molecular Cytogenetics;p53-binding protein 1;Paint;Primary Neoplasm;Productivity;programs;Recurrence;repaired;Repetitive Sequence;Research Personnel;response;Ribosomal DNA;Services;single molecule;Single-Stranded DNA;Site;Spectral Karyotyping;telomere;tool;Topoisomerase Inhibitors;Validation;Yeasts

PROJECT_TITLE: CORE B Symington


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: The Computational Genomic core (Core C) will provide state-of-the art data analysis and integration for all 4 projects. It has become apparent that a rate limiting factor of high- throughput, genomics analyses is the ability to efficiently analyze large and complex datasets. By centralizing all analyses under the Dr. Rabadan leadership, the Core will greatly enhance research productivity of all Projects.

PROJECT_TERMS: analysis pipeline;Biometry;blind;Calibration;Chromatin;Chromosomal translocation;Classification;Collaborations;complex data;computational pipelines;Computational Technique;computer science;Computing Methodologies;Data;Data Analyses;data integration;Data Set;deep learning;Development;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;Double Strand Break Repair;Epigenetic Process;experimental study;Genetic Transcription;genome-wide;genomic data;Genomics;Germ Lines;Germ-Line Mutation;Goals;insertion/deletion mutation;Leadership;Learning;Machine Learning;Malignant Neoplasms;Mathematics;member;Methods;Modeling;Mutation;novel;Physics;Point Mutation;Portraits;Positioning Attribute;Productivity;Research;Role;Scientist;Source;statistics;Structure;Techniques;Technology;Testing;theories;tool;Training;training opportunity;transcriptomics;tumor;Universities;whole genome;XCL1 gene

PROJECT_TITLE: CORE C Rabadan


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: IOWA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The Center for Gene Therapy of Cystic Fibrosis (CF) seeks to improve the quality of life for CF patients by both enhancing the field's understanding of CF pathogenesis and developing molecular therapies. The Center acts as a conduit that brings new talented investigators into the field of CF research and enhances the research infrastructure needed for collaborative discoveries and the development of novel therapies. The Research Cores of the Center also serve numerous other institutions in their mission to cure CF.

PI_NAMEs: ENGELHARDT, JOHN F (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acceleration;Adolescent;Affect;airway epithelium;Animal Model;Area;Biological Models;career;Cell Physiology;cell type;Cells;cellular targeting;Clinical;comorbidity;Comparative Pathology;Core Facility;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Dependovirus;Development;differentiation in vitro;Disease;disease phenotype;effective therapy;Endocrine;Ensure;Environment;Epithelium;experimental study;Faculty;faculty research;Family suidae;Ferrets;Fertilization;Fibrocystic Disease of Pancreas;Fostering;Funding;Gall Bladder Diseases;Gallbladder;gene therapy;Generations;Genes;Genetic;Genetic Engineering;genetic manipulation;graduate student;Growth;histological specimens;Human;improved;in utero;in vivo;innovation;Innovative Therapy;Institution;Intestinal Diseases;Intestines;Iowa;Laboratories;Lentivirus;Liver diseases;Lung;Lung Diseases;member;Mentors;Mission;Modeling;Molecular;Movement;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new growth;next generation;novel;novel therapeutics;Onset of illness;Organ;Organoids;Outcome;Pancreas;Pancreatic Diseases;Pancreatic duct;Pancreatitis;Pathogenesis;Peer Review;porcine model;Postdoctoral Fellow;postnatal;Process;Productivity;programs;Pulmonary Cystic Fibrosis;Quality of life;recombinant viral vector;Research;research and development;Research Infrastructure;Research Personnel;Resources;Role;Science;stem cells;Strategic vision;Talents;Technology;technology development;tenure track;Testing;Therapeutic Studies;Tissues;tool;Training;translational research program;Universities;vector;Viral Vector;VX-770


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Rare Diseases

PROJECT_TERMS: Accountability;Achievement;Administrator;Advisory Committees;Area;Budgets;career;Charge;college;Communities;cost effective;Cystic Fibrosis;Decision Making;Documentation;Educational workshop;Ensure;Evaluation;Funding;gene therapy;Goals;graduate student;Group Meetings;Iowa;Journals;Judgment;Leadership;Maintenance;Medicine;member;Mentors;Molecular;Monitor;Policies;Postdoctoral Fellow;programs;Publications;Questionnaires;Records;recruit;Reporting;Research;Research Personnel;Series;Services;Summary Reports;Supervision;Talents;United States National Institutes of Health;Universities;Visit;web site;working group

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Rapid assessment and response to the increasingly diverse tobacco market are essential to informing and evaluating FDA’s current and pending regulatory actions, including proposed product standards, pending marketing authorizations for e-cigarettes, and the modified risk tobacco products (MRTPs) pathway. This U01 proposal assembles a large collaborative network that triangulates multiple data sources to establish the Center for Rapid Surveillance of Tobacco (CRST), which will perform surveillance of tobacco product marketing, the tobacco product marketplace, and tobacco use behaviors, transforming tobacco surveillance to be rapid, comprehensive, and coordinated, with salient findings fed immediately into traditional data collection systems. By identifying and evaluating signals in a timely fashion, the CRST will generate critical actionable information about changes in tobacco products which can inform FDA’s regulation of tobacco products leading to a substantial public health impact.

PI_NAMEs: DELNEVO, CRISTINE D (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Attention;authority;Authorization documentation;Behavior;behavior change;Case Study;Characteristics;Cigar;Cigarette;Collaborations;college;Communities;Complex;Data;Data Analyses;Data Collection;Data Sources;Descriptor;Detection;Disparity;Early identification;Electronic cigarette;electronic cigarette use;Emerging Tobacco Products;Ensure;Evolution;experience;Growth;High Prevalence;high school;High School Student;improved;interest;JUUL;Knowledge;Maps;Marketing;Measurement;Measures;medical specialties;Menthol;Methods;Modernization;Modified Risk Tobacco Product;Monitor;multiple data sources;news;Newspapers;non-cigarette tobacco product;Pathway interactions;Persons;Population;Population Surveillance;Positioning Attribute;Price;Process;programs;Public Health;Reporting;Resources;response;Sales;Sentinel;Shapes;Signal Transduction;Site;Smokeless;Smokeless Tobacco;social media;Spottings;standardize measure;Surveillance Methods;Surveys;System;Time;Tobacco;tobacco advertising;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco Surveillance;Tobacco use;uptake;web site;young adult;Youth

PROJECT_TITLE: Rutgers Center of Excellence in Rapid Surveillance of Tobacco

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-M(50)R]


PI_NAMEs: SINN, PATRICK L (contact)

PROJECT_TERMS: Address;airway epithelium;Animal Model;Archives;Baculoviruses;base editing;Biological Assay;Brain Diseases;Cardiovascular system;Catalogs;Cell Culture Techniques;Cell Line;Cells;Communication;Communities;Consultations;Country;CRISPR/Cas technology;Custom;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Databases;delivery vehicle;Dependovirus;design;Development;Discipline;Disease;disease-causing mutation;Education;experimental study;expression vector;Eye diseases;Fertilization;Fostering;Gene Delivery;gene editing technology;gene repair;gene replacement;gene therapy;Gene Transfer;Generations;Genes;Genome engineering;Goals;Guide RNA;Heart Diseases;Hybrids;improved;In Vitro;in vivo;innovation;Institution;International;Iowa;Joints;Journals;Kidney Diseases;Label;Lentivirus;Literature;Liver diseases;loss of function;Lung Diseases;Macular degeneration;Malignant Neoplasms;meetings;Methods;Mutation;Myopathy;Neurobiology;neuromuscular system;new technology;novel;Pancreatic Diseases;Participant;Phase;Phenotype;Plasmids;Preparation;Production;protein function;Protocols documentation;Quality Control;Reagent;recombinant adenovirus;recombinant viral vector;Reporter;Research;research and development;Research Design;Research Personnel;Retroviridae;Role;Services;Small Interfering RNA;stem cells;success;System;Technology;Technology Transfer;Testing;therapeutic gene;therapeutic transgene;therapy development;tool;Training;Transgenes;Universities;Vaccinia;vector;Viral;Viral Vector;Virus;webinar

PROJECT_TITLE: Vector Core-Core 2


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Nearly 25% of Veterans have diabetes, which costs the VA 1.5 billion annually. Diabetes is associated with impaired daily functioning and quality of life. Most Veterans to do not engage in recommended physical activity and other diabetes self-management behaviors. Most self-management takes place outside of medical visits; however, factors related to self-management are only assessed at the time of medical visits, likely missing large amounts of variability. The proposed study will use real-world ambulatory assessment methods to examine daily fluctuations in symptoms like mood, pain, and stress, and social context like social support and daily interactions in relation to physical activities, in real-time, in Veteran’s own environments. Results will inform more effective assessment tools and interventions that may improve daily functioning and quality of life. Technology-supported interventions can provide the right type of support at the right time by adapting to an individual’s changing internal and contextual state to maximize physical, psychological, and social functioning.

PI_NAMEs: WOOLDRIDGE, JENNALEE S (contact)

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Accounting;Assessment tool;associated symptom;Attenuated;Behavior;Behavioral Medicine;Blood Glucose;blood glucose regulation;career;Caring;Characteristics;Clinical;clinical application;clinical decision-making;Clinical Trials;contextual factors;cost;daily functioning;Data;Data Collection;Depressed mood;design;Development;Diabetes Mellitus;diabetes self-management;Ecological momentary assessment;Enrollment;Environment;Foundations;Functional impairment;Future;Goals;Health Care Visit;Impairment;improved;Individual;Informal Social Control;innovation;Intervention;Life;Measures;Medical;medical appointment;medication compliance;Mentors;Methods;mhealth interventions;Modeling;Monitor;Moods;Nature;Non-Insulin-Dependent Diabetes Mellitus;Pain;Participant;Pathway Analysis;Patients;Persons;Physical activity;Physical assessment;Post-Traumatic Stress Disorders;psychologic;Quality of life;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Sampling;Self Management;Social Environment;Social Functioning;Social Interaction;Social support;Source;Statistical Data Interpretation;Stress;Surveys;Symptoms;Technology;technology intervention;Testing;theories;Time;Training;Veterans;Visit

PROJECT_TITLE: Real-World Assessment of Daily Functioning in Veterans with Type 2 Diabetes

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Affect;Alleles;Amendment;Animal Experiments;Animal Model;Animals;Antibiotics;Area;Arginine;biobank;Biological;Biophotonics;Birth;Blood;blood glucose regulation;Breeding;Bronchoalveolar Lavage;Caring;Cell Therapy;cell type;Cells;cellular targeting;Certification;Client;Clinical;Collaborations;college;Communities;Comparative Pathology;Comparative Study;congenic;Containment;cost;cost effective;cost effectiveness;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Databases;delivery vehicle;Delta F508 mutation;Development;Disease;drug testing;Ductal Epithelial Cell;Endocrine;Ensure;Family suidae;Farm;Feces;Ferrets;Fibrocystic Disease of Pancreas;Foundations;Functional disorder;Funding;Gallbladder;gene therapy;Gene Transfer;gene-targeted therapy;Generations;Genetic;Genetic Engineering;Genotype;Glucose Clamp;Glucose tolerance test;Harvest;Histologic;IACUC;Image;Inbreeding;Internal Ribosome Entry Site;Intestines;investigator training;Iowa;islet;Islets of Langerhans;Knock-in;Knock-out;Laboratories;Lung;Maps;Mediating;Medicine;member;Metabolic;Methods;Mission;Modeling;Molecular;Monitor;Mus;Natural regeneration;new technology;offspring;OGTT;Organ;Organoids;Pancreas;Pancreatic duct;Pathogenesis;Pathology;Pharmaceutical Preparations;pharmacologic;Physiological;Population;porcine model;Preparation;Procedures;Production;progenitor;programs;Protocols documentation;Pulmonary function tests;Quality Control;recombinant virus;Recording of previous events;Reporter;Research;Research Personnel;Research Support;Resources;sample collection;Sampling;Services;shared database;somatic cell nuclear transfer;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem cell therapy;stem cells;synergism;System;Techniques;Testing;Tissue Harvesting;Tissue Sample;Tissue Viability;Tissues;Training;Transgenic Organisms;Translational Research;United States Department of Agriculture;Universities;Urine;Vas deferens structure;Viral Vector;VX-770;Weight Gain

PROJECT_TITLE: Animal Models Core-Core 3


PI_NAMEs: GIBSON-CORLEY, KATHERINE NICOLE (contact)

PROJECT_TERMS: animal care;Animal Disease Models;Animal Experimentation;Animal Experiments;Animal Model;Area;Autopsy;Board Certification;cell type;Cellular Morphology;Clinics and Hospitals;comparative;Comparative Pathology;Cystic Fibrosis;cystic fibrosis mouse;Data Analyses;Diagnostic;Disease;Equipment;experience;Experimental Designs;Family suidae;Ferrets;gene therapy;Goals;Histologic;histological specimens;Histology;histotechnology;Human;Inflammation;instrumentation;Iowa;Laboratories;Manuscripts;Medicine;Mission;Modeling;Morphology;Mus;Organ;Pathologist;Pathology;Protocols documentation;Quantitative Evaluations;Research;Research Personnel;research study;Resources;Scanning;Scientist;Services;Source;Specimen;Stains;Technical Expertise;Techniques;Tissue Banks;tissue processing;Tissue Sample;Tissues;Translational Research;Translations;Universities;Veterinary Pathology;Work;Writing

PROJECT_TITLE: Comparative Pathology Core-Core 4


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Complex interactions among neurons, glia, immune and endothelial cells in the microenvironment drive the progression, treatment resistance, and recurrence of glioblastoma (GBM), an incurable primary brain tumor. The short-term goal of this project is to elucidate how a poorly understood microenvironmental interaction—namely, mitochondrial transfer from neural cells to GBM—drives tumorigenicity, focusing on astrocytes as predominant organelle donors. The long-term goal and future studies will (a) investigate the differential mechanistic role of mitochondrial transfer from diverse brain cell lineages, (b) interrogate how mitochondrial transfer influences spatio-temporal heterogeneity in primary and recurrent patient GBM specimens, and (c) develop therapeutics targeting molecular mediators of this protumorigenic interaction.

PI_NAMEs: WATSON, DIONYSIOS C (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acetylation;Address;Affect;Astrocytes;ATAC-seq;Automobile Driving;Biological Assay;Biology;Bone Marrow;Brain;brain cell;Brain Neoplasms;cancer cell;career;career development;cdc Genes;Cell Cycle;Cell Lineage;Cell model;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Chromatin;Coculture Techniques;Complex;Cytoskeleton;Data;design;Development;Disease;Endogenous Retroviruses;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;Fellowship;fluorophore;Frequencies;Future;Gap Junctions;Gene Expression;Gene Expression Profile;genetic manipulation;Genus Hippocampus;Glioblastoma;Glioma;Goals;Heterogeneity;Histone Acetylation;Human;Hypoxia;Immune;Immunodeficient Mouse;Immunotherapy;In Vitro;in vivo;inhibitor;insight;knock-down;Knowledge;Leukocytes;Link;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Mentorship;Metabolic;Metabolism;metabolomics;Microglia;Mitochondria;Mitochondrial DNA;Mitochondrial Proton-Translocating ATPases;mitochondrial therapeutics;Mitosis;Modality;Modeling;Molecular;molecular targeted therapies;Morphology;mouse model;Mus;neoplastic cell;neural;Neuroglia;Neurons;Non-Malignant;Operative Surgical Procedures;Organelles;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phase;Phenotype;Physicians;Primary Brain Neoplasms;Process;progenitor;programs;Proliferating;Proteins;purine/pyrimidine metabolism;Radiation therapy;receptor;Recurrence;Reporter;Research;Resistance;Role;Scientist;self-renewal;Shapes;single-cell RNA sequencing;Sorting;spatiotemporal;Specimen;standard care;stem;stem cells;Stress;Supporting Cell;syncytin;Testing;Therapeutic;therapeutic development;therapeutic target;therapy resistant;Training;transcriptome sequencing;Transgenic Mice;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumorigenicity

PROJECT_TITLE: Mitochondrial transfer from astrocytes to glioblastoma cells drives tumor growth


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Digestive Diseases;Gene Therapy;Genetics;Lung;Rare Diseases

PI_NAMEs: ZABNER, JOSEPH  (contact)

PROJECT_TERMS: Affect;Air;airway epithelium;Animals;biobank;bioelectricity;Biological Models;Cell Culture Techniques;Cell Line;Cells;Clinical;Cloning;Collaborations;Cystic Fibrosis;Development;Diabetes Mellitus;Digestive System Disorders;Disease;Educational process of instructing;Epithelial Cells;Epithelium;Evaluation;experimental study;Family suidae;Ferrets;Fibroblasts;Freezing;Functional disorder;Gallbladder;Gene Expression Profile;gene therapy;Genotype;Goals;Health;Human;human model;human tissue;improved;in vitro Model;inhibitor;Institution;Intestines;investigator training;Iowa;Kidney;Liquid substance;Liver diseases;Lung;Lung Diseases;Measurement;Methods;Mission;Modeling;Molecular;Morphology;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrition Disorders;Organ;Organoids;Pancreas;Persons;Phenotype;Plasmids;post-transplant;Process;Quality of life;Records;Research;Research Personnel;Specimen;Study models;Surface;Technical Expertise;Tissues;Universities;Vas deferens structure;Work

PROJECT_TITLE: Cells and Tissue Core-Core 5


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: LARSON ODE, KATIE MARIE ULRING (contact)

PROJECT_TERMS: Animal Model;Archives;Area;Bacterial Typing;Basic Science;biobank;Biological;biological specimen archives;Biometry;Blood;Bronchoalveolar Lavage Fluid;central database;Cholecystectomy;Clinical;clinical care;clinical encounter;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collection;college;Conduct Clinical Trials;Consent;Core Facility;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Databases;design;Disease;DNA;early phase trial;Electronics;Faculty;Feces;Ferrets;Functional disorder;Funding;Future;Gallbladder;gene therapy;Goals;Good Clinical Practice;Human;human subject;Informed Consent;Infrastructure;Institutional Review Boards;Intervention Studies;Investigator-Initiated Research;liver function;Medicine;member;Molecular;Monitor;Nature;novel therapeutics;OGTT;Operative Surgical Procedures;participant enrollment;Pathology;Patient Recruitments;Patients;Plasma;porcine model;Procedures;Process;prospective;Recording of previous events;recruit;Research;Research Personnel;Resources;sample collection;Sampling;Specific qualifier value;Specimen;Standardization;support network;System;Time;Translating;Translational Research;translational scientist;Urine;Visit;Whole Blood;Work

PROJECT_TITLE: Clinical Core-Core 6


ORG_CITY: PHOENIX

ORG_NAME: PHOENIX VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: Project Narrative  Traumatic brain injury (TBI) is associated with later development of impaired cognitive function and dementia. The mechanisms underlying this relationship remain largely unknown. TBI causes early and late impairment of cerebrovascular function, much in the same way that dementia disorders such as Alzheimer’s disease and vascular dementia were associated with early development of impaired vascular function. Our overall goal is to test the hypotheses that long-term mild TBI (mTBI)-induced cognitive dysfunction is due, at least in part, to persistent cerebrovascular dysfunction and that early onset mTBI will contribute to worse cerebrovascular and cognitive function with concomitant hypertension. We will use a validated model of diffuse mTBI in rats using fluid percussion injury. We will measure cognitive function using novel object recognition tasks. We will measure cerebrovascular function in living animals using magnetic resonance imaging and by measuring reactivity of blood vessels isolated from the brain. We will determine the relationship between cerebrovascular function and cognitive function and evaluate whether aerobic exercise training will attenuate the effects of mTBI. In rats genetically predisposed to develop hypertension, we will also compare cerebrovascular and cognitive function with mTBI versus those without. The proposal is significant in filling in our knowledge gaps about how mTBI causes impaired cognitive function as well as understanding the underlying causes on how TBI induces impaired cerebrovascular function. If successful, the study will uncover important new treatment pathways that could be used to prevent impaired cognitive and cerebrovascular function following TBI.

PI_NAMEs: LIFSHITZ, JONATHAN ;MIGRINO, RAYMOND QUEZON (contact)

PROJECT_TERMS: Acute;Aerobic Exercise;Affect;Afghanistan;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Attenuated;base;Blood Vessels;Brain;Brain-Derived Neurotrophic Factor;Carbon Dioxide;Cardiac;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;cerebral artery;cerebral autoregulation;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Chronic;chronic traumatic encephalopathy;cognitive function;Coronary artery;Data;Dementia;Development;Diffuse;Disease;disorder risk;early onset;Echocardiography;Endothelium;exercise training;Exposure to;fluid percussion injury;Genetic Predisposition to Disease;Goals;Histopathology;Hypertension;hypertensive;Impaired cognition;Impairment;improved;in vivo;Inbred SHR Rats;Injury;insight;Iraq;Knowledge;Link;Magnetic Resonance Imaging;Measures;Mediating;mild traumatic brain injury;military veteran;Modeling;Molecular;Morbidity - disease rate;mortality;Neurons;neurovascular;neurovascular coupling;normotensive;novel;object recognition;Organ;Outcome;Outcome Measure;Pathologic;Pathway interactions;Perfusion;persistent symptom;Physiological;pressure;prevent;Rattus;Regulation;rehabilitation strategy;Reporting;response;Rest;Role;service member;sham surgery;Soldier;Sprague-Dawley Rats;stressor;Structure;synergism;Testing;Traumatic Brain Injury;Vascular blood supply;Vascular Dementia;Vascular Diseases;Veterans;Work;Youth

PROJECT_TITLE: Mechanistic role of vascular dysfunction in TBI-mediated cognitive dysfunction

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Rare Diseases

PROJECT_TERMS: Advisory Committees;animal model development;Area;Award;career development;Carrier State;Collaborations;Cystic Fibrosis;cystic fibrosis related diabetes;Decision Making;Development;Diabetes Mellitus;Endocrine System Diseases;Evolution;Exclusion;Feedback;Ferrets;Fostering;Functional disorder;Funding;gene therapy;Genetic Diseases;glucose metabolism;Goals;Grant;Growth;Individual;Infection;interest;Intestinal Fibrosis;Iowa;Kidney Diseases;Lung;member;Mentors;Methods;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;Other Genetics;Pancreatic Diseases;pathogen;Pilot Projects;porcine model;Productivity;professor;programs;Publications;Pulmonary Cystic Fibrosis;Recommendation;Research;Research Personnel;Research Support;Running;Science;Series;stem cell biology;success;tenure track;United States National Institutes of Health;Universities;vector;working group

PROJECT_TITLE: Pilot and Feasibility Program


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The goal of this research is to understand how neurons in the retina convert the image on the back of the eye into electrical signals for transmission to the brain. We will focus on understanding the neural signals related to night-vision and to the detection of motion in the visual scene. The results of the investigations will help us to understand how the neural networks function of the healthy eye, which will help to understand how pathological conditions compromise vision, and thereby ultimately point to possible novel therapies and prosthetics for the treatment of blindness.

PI_NAMEs: TAYLOR, WILLIAM ROWLAND (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acute;Amacrine Cells;antagonist;Back;Blindness;Brain;Calcium;Cell Extracts;cell type;Cells;Characteristics;chemical release;Chemical Synapse;Cone;Coupled;Data;Detection;Electrical Synapse;Electrophysiology (science);Eye;ganglion cell;Gap Junctions;Gene Expression;Goals;Image;imaging approach;In Vitro;Inner Plexiform Layer;Interneurons;Investigation;Knowledge;Label;Learning;Light;Maps;Measures;Microscope;Molecular;Morphology;Motion;motion sensitivity;Mus;neural;neural network;neuronal cell body;Neurons;neurotransmission;Neurotransmitters;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;NOS1 gene;novel;novel therapeutics;object motion;optogenetics;Output;patch clamp;Pathologic;Photoreceptors;Physiological;Play;Population;postsynaptic;Preparation;Process;Property;Prosthesis;receptive field;Research;response;Retina;Retinal Ganglion Cells;retinal neuron;Role;signal processing;Signal Transduction;Slice;sound;spatiotemporal;Stimulus;Synapses;Synaptic Potentials;Testing;Tracer;transmission process;Vision;Visual;Visual evoked cortical potential;visual processing;Work

PROJECT_TITLE: Functional properties of amacrine cells in the mammalian retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative  Our vision depends on the flexible interplay of excitatory and inhibitory circuits across the visual cortex. Understanding the connectivity and dynamics underlying visual perception would not only elucidate key processes of cortical computations but may also grant insights into understanding maladaptive changes to connectivity or network function that underlie pathophysiology of neurological disorders. This project aims to provide a mechanistic basis for a key process of visual computation and further our understanding on how the visual cortex forms a cohesive representation of the visual environment.

PI_NAMEs: SADAHIRO, MASATO  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Architecture;area striata;Automobile Driving;awake;Calcium;cell type;Cells;Code;Dependence;Electrophysiology (science);Environment;excitatory neuron;experimental study;flexibility;Functional disorder;Goals;Grant;Holography;Hybrids;Image;In Vitro;in vivo;inhibitory neuron;innovation;insight;Interneurons;Lateral;Learning;Location;Maps;Measures;Mediating;Methods;Modeling;Mus;Nervous System;Nervous System Disorder;neural;Neurons;Neurosciences;novel;novel strategies;optogenetics;Photic Stimulation;Physiological;Play;Population;preference;Process;Property;Pyramidal Cells;receptive field;recruit;Resolution;response;retinotopic;Role;Scheme;Sensory;Shapes;Somatostatin;Specificity;Stimulus;success;Synapses;Techniques;Technology;Testing;Training;training opportunity;two-photon;Virus;Vision;Visual;Visual Cortex;Visual Perception;visual processing;visual stimulus;Wakefulness;Whole-Cell Recordings;Work

PROJECT_TITLE: Cell-Type-Specific Mechanisms of Contextual Modulation in the Visual Cortex


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: VISITING NURSE SERVICE OF NEW YORK

PHR: PROJECT NARRATIVE Gender minorities experience disparities in physical and mental health. Gender-affirming healthcare has the potential to mitigate these disparities, yet this population faces multiple barriers to accessing competent care. This mixed-method, longitudinal cohort study examines changes in psychosocial adjustment and health-related quality of life after gender-affirming surgery, informing the development of future home- and community-based healthcare interventions to promote their health and wellbeing.

PI_NAMEs: BOCKTING, WALTER O.;RYVICKER, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Admission activity;Affect;Area;behavior influence;Caring;Chronic;Clinical;clinical practice;cohort;Cohort Studies;Communities;community based service;Community Health;design;Development;Discipline of Nursing;Discrimination;Disparity;disparity reduction;Emotional;Employment;Environment;evidence base;experience;Face;Future;Gender;gender affirmation;gender affirming care;Gender Confirmation Surgery;gender expression;Gender Identity;gender minority;gender minority group;gender transition;Goals;Health;health assessment;Health behavior;health care availability;health care disparity;health disparity;Health Personnel;health related quality of life;Health Services;Health Services Accessibility;Healthcare;high risk;HIV risk;Home;Home Care Services;improved;Individual;informant;innovation;instrument;intersectionality;Intervention;Interview;intimate behavior;Investigation;Life;Life Cycle Stages;Link;Longitudinal cohort study;Medical;member;Mental Depression;Mental Health;Methods;Modeling;New York;nonbinary;Nursing Services;Operative Surgical Procedures;Outcome;Participant;Personal Satisfaction;Persons;Phase;physical conditioning;Population;Positioning Attribute;Preparation;Process;programs;prospective;psychosocial adjustment;psychosocial development;Public Health;Qualitative Methods;Quality of life;Race;recruit;Research;resilience;Risk Behaviors;Sampling;satisfaction;Science;Self Care;service programs;Services;Sex Functioning;sexual identity;social;social stigma;Social Well-Being;Societies;socioeconomics;Stress;Structure;Suicide;Time;Training;transgender;Trust;Visiting Nurse;Well in self

PROJECT_TITLE: Gender Affirmation, Quality of Life, and Access to Care: A Mixed-Method Longitudinal Investigation

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project narrative Cortical visual impairment (CVI) is the most common cause of pediatric visual impairment in developed countries, but there is no evidence-based treatment, in part due to the absence of a validated and comprehensive method of visual assessment that can be used as an outcome measure in clinical trials. The primary objective of this proposal is to use high resolution eye tracking and machine learning to develop and validate a CVI eye tracking severity score. The proposed studies will establish eye tracking as a quantitative, objective, and comprehensive measure of visual function in children with CVI, with widespread applicability in both clinical and research settings via the CVI eye tracking severity score, which will automate data interpretation.

PI_NAMEs: CHANG, MELINDA  (contact)

PROJECT_TERMS: Ablation;Active Learning;Adopted;Adverse effects;Age;Behavior;Biomedical Engineering;Brain;California;Categories;cerebral visual impairment;Characteristics;Child;Childhood;Classification;Clinic;Clinical;Clinical assessments;Clinical Trials;Clinical Trials Design;cohort;Collaborations;comorbidity;computer monitor;Contrast Sensitivity;Cornea;Crowding;Data;Data Analyses;Data Science;Data Set;deep learning;deep neural network;Developed Countries;Disease;Electrophysiology (science);Enrollment;Evaluation;Evidence based treatment;Exhibits;experience;Eye;Foundations;Frequencies;Future;gaze;Goals;International;Interview;Joints;K-Series Research Career Programs;Knowledge;Laboratories;large datasets;Learning;Light;Longitudinal Studies;Los Angeles;Machine Learning;machine learning model;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Neural Network Simulation;neurodevelopment;Neurodevelopmental Disorder;Neurologic;next generation;novel;oculomotor;Ophthalmology;Outcome Measure;Parents;Patients;Pediatric Hospitals;programs;prospective;Protocols documentation;Quality of life;Quality of Life Assessment;Questionnaires;Research;Research Personnel;Resolution;Saccades;Sampling;Severities;sex;signal processing;success;targeted treatment;Techniques;Technology;Time;Training;Translating;translational potential;Universities;Vision;Vision Tests;Visual;Visual Acuity;visual control;visual dysfunction;Visual evoked cortical potential;Visual impairment;Visual Pathways;visual stimulus;Visual System;visual tracking

PROJECT_TITLE: Validating a machine learning model of eye tracking in children with cortical visual impairment (CVI)


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARATIVE Human stem cell derived tissues offer new models for studying human retinal degenerative eye disease, potentially providing new insight into the biology of inherited retinal degenerations. In this application, we propose to use stem cell derived AIPL1 mutant reporter lines to explore how variations in different functional domains lead to the disease phenotypes observed in LCA and CORD. We propose to study the consequences of mutations in different functional domains in rods and cones and will develop a gene-therapy based approach to prevent retinal degenerative disease.

PI_NAMEs: WAHLIN, KARL J (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age related macular degeneration;Alleles;Animals;Apoptosis;ARA9 protein;Binding;Binding Proteins;Biological Models;Biology;Birth;Blindness;Cell Cycle Proteins;Cell Death;Cell Survival;cell type;Cells;Childhood;Clinical;comparative;Complex;Cone;cone-rod dystrophy;CRISPR/Cas technology;Cyclic GMP;Data;Defect;Disease;disease phenotype;disease-in-a-dish;DNA Repair;early onset;Electrophysiology (science);Experimental Models;Eye diseases;Fluorescence;Freezing;Functional disorder;gene correction;Gene Expression;gene therapy;gene-editing approach;Genes;genome editing;Goals;Human;human disease;human pluripotent stem cell;human stem cell-derived;in vivo;Inherited;inherited retinal degeneration;innovation;innovative technologies;insight;Knock-out;knockout gene;Knowledge;Label;Laboratories;Lead;Leber's amaurosis;live cell imaging;Measures;Modeling;Molecular;Monitor;Morphology;mRNA Expression;Mus;mutant;Mutation;Organoids;Pathogenesis;Pathway interactions;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;Pluripotent Stem Cells;polyproline;Population;prevent;Primates;Property;Proteins;Recombinant adeno-associated virus (rAAV);Recovery of Function;repaired;Reporter;Resources;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Rod;Role;RPE65 protein;selective expression;Severities;Sorting;stem cell derived tissues;stem cells;Structure;Study models;System;Testing;therapy development;Time;Tissues;Variant;Vertebrate Photoreceptors;Viral;Western Blotting;Work

PROJECT_TITLE: Pluripotent Stem Cell Derived 3D Retinas for Studies of Early Onset Retinal Degeneration

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE Isolation, insecurity and uncertainty can impact the psychiatric health of pregnant mothers, with substantial lasting morbidity for mother and child. The goal of this project is to lay critical foundations for understanding the biological consequences of social isolation and uncertainty stress, and the roles they play in both maternal and child outcomes.

PI_NAMEs: BRITO, NATALIE HIROMI;THOMASON, MORIAH E (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Address;Affect;Age;Allopregnanolone;Animals;Architecture;Area;arm;Attention;awake;Award;Behavior;Behavior assessment;Behavioral;Bioenergetics;Biological;Biology;Biophysics;Brain;care providers;Child;Child Development;cohort;Collection;Communicable Diseases;course development;COVID-19;COVID-19 pandemic;current pandemic;Data Collection;Development;Diffusion;Disasters;Economics;Electrocardiogram;Electroencephalography;Emotional;Endocrine;Enrollment;Environment;Etiology;Event;experience;family support;Fatty Acids;Fiber;follow-up;Foundations;Glucose;Goals;Health;Height;Home environment;Hormonal;Hour;Human;Human Development;Hydrocortisone;imaging approach;Infant;Inflammation;Inflammatory;innovation;Investigation;Knowledge;Learning;Leptin;Life;Literature;longitudinal, prospective study;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;Medical;Mental Health;Modality;Morbidity - disease rate;Mothers;Movement;multimodal neuroimaging;multimodality;Myelin;neurobehavior;neurobehavioral;neurobehavioral disorder;Neurocognitive;neurodevelopment;new technology;New York City;offspring;Outcome;pandemic disease;pandemic stressor;Parents;Pathway interactions;Perinatal;Persons;Phase;physical conditioning;Physiological;Play;Policy Maker;postnatal;Postpartum Depression;Postpartum Period;preclinical study;Pregnancy;pregnant;Pregnant Women;prenatal;Prevalence;psychobiologic;psychobiology;psychologic;Psychopathology;Psychosocial Stress;public health relevance;Questionnaires;recruit;Relaxation;remote sensing;Research;respiratory;response;restraint;Risk;Role;sensor technology;serial imaging;Sinus Arrhythmia;Social Environment;Social isolation;Societies;sound;Stress;stressor;Structure;Sum;Surveys;System;Testing;Time;tool;Uncertainty;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: “Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: NARRATIVE Treatment planning for radiation therapy, where an optimal treatment strategy is designed for each individual patient and executed for the whole treatment course, plays a central role for the success of radiation therapy treatment. The current treatment planning workflow is inefficient and produces plans with sub-optimal quality, substantially deteriorating treatment outcomes. Jointing strong research and clinical expertise at UT Southwestern Medical Center with extensive commercial product development experience at Varian Medical Systems Inc, this project will develop and translate an artificial intelligence planner that is capable of efficiently generating high quality treatment plans.

PI_NAMEs: JIA, XUN ;JIANG, STEVE BIN (contact);NGUYEN, DAN

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Affect;algorithm development;Anatomy;Area;Artificial Intelligence;Attention;Back;Beds;Behavior;Cancer Patient;cancer therapy;Caring;chemotherapy;Clinical;Clinical Research;clinical translation;Communities;Complex;Complication;Data;Decision Making;design;Deterioration;Development;Dose;Ensure;Environment;Evaluation;Evolution;experience;Failure;Feedback;Goals;Growth;Head and Neck Cancer;head and neck cancer patient;Human;improved;individual patient;industry partner;innovation;Intention;Joints;Learning;learning algorithm;learning progression;Malignant neoplasm of prostate;Manuals;Mathematics;Measures;Medical;Medical center;Mind;Modality;model development;Modeling;Modernization;new technology;Normal tissue morphology;Operative Surgical Procedures;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;Performance;Physicians;Play;population based;Probability;Process;product development;prototype;Radiation therapy;Research;Resource-limited setting;Resources;response;Role;routine practice;Scheme;Site;Structure;success;System;Testing;Time;Training;Translating;Translations;Treatment outcome;treatment planning;Treatment Step;treatment strategy;tumor;Validation;validation studies

PROJECT_TITLE: Human-like automated radiotherapy treatment planning via imitation learning


NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Digestive Diseases;Food Allergies;Nanotechnology;Natural Products;Nutrition;Pediatric

ORG_CITY: Briarcliff Manor

ORG_NAME: GENERAL NUTRACEUTICAL TECHNOLOGY, LLC

PHR: Narrative Food Allergy is a serious and sometimes fatal condition affecting nearly 30 million people in the US for which there is currently no cure. We developed an innovative berberine nanoparticle called NIT-X that in preclinical murine studies causes rapid, selective and lasting abrogation of IgE and completely protects from anaphylaxis. Understanding how NIT-X causes sustained reduction of food specific-IgE production advances scientific knowledge of food allergy mechanisms and facilitates the development of a curative therapy.

PI_NAMEs: LI, XIU-MIN  (contact);YANG, NAN

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adverse effects;Affect;Aftercare;Allergens;Allergic;Allergy to peanuts;Anaphylaxis;Anti-Allergic Agents;anti-IgE;Antibodies;Awareness;B-Lymphocytes;BCL6 gene;Berberine;Binding;Biological Availability;Body Surface Area;C3H/HeJ Mouse;Cashew nut;Cells;chemokine;Childhood;Clinical;clinical practice;cross reactivity;curative treatments;cytokine;Data;Development;Dose;Early treatment;effective therapy;experience;experimental study;feeding;Food;Food Hypersensitivity;Formulation;Genes;Genetic Transcription;Goals;Grant;Human;Hypersensitivity;IgE;Immunoglobulin A;Immunoglobulin G;in vivo;Individual;innovation;Interferon Type II;Interleukin-13;Interleukin-4;Intervention;Investigation;Juglans;Knowledge;Mediating;Minor;Molecular;Monitor;mouse model;Mus;Names;nanomedicine;nanoparticle;novel;novel therapeutics;Nut Hypersensitivity;Nuts;omalizumab;Oral;Oral Administration;oral immunotherapy;Outcome;Outcome Measure;Parents;Pathologic;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Philodendron;Pilot Projects;Plasma;Plasma Cells;Population;pre-clinical;preclinical safety;prevent;Production;programs;promoter;Public Health;Reaction;reconstitution;Regulation;Resistance;response;restoration;restraint;Risk;Scientific Advances and Accomplishments;Serum;Signal Transduction;Site;small molecule;STAT6 gene;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;Transcription Repressor;transcriptome sequencing;Trees;Work

PROJECT_TITLE: IgE Suppressing Berberine Nanomedicine for Treatment of Peanut and Tree nut Allergies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]