ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS TYLER

ORG_STATE: TX

PHR: Project Narrative This project will develop a new computational paradigm to drastically accelerate the inversion of ultrasound measurements for imaging and the optimization of insonation profiles for therapies using limited computer resources. As a result, ultrasound-based technologies can be fully automated, be deployed in real-time, and fit into the clinical/surgical workflow where there is a great need for continuous non-invasive monitoring of patients during and after cardiovascular procedures.

PI_NAMEs: KHAJAH, TAHSIN  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Acceleration;Accounting;Acoustics;Algorithms;analytical method;attenuation;Automation;Biological;Biological Models;biomedical imaging;Cardiovascular system;career development;Clinical;Collaborations;college;Complex;Computational Geometry;computer program;Computer Simulation;computerized tools;Computers;Computing Methodologies;computing resources;cost;Data;Data Set;Dedications;design;Development;Differential Calculus;Differential Equation;Education;Educational workshop;Elements;Employment;empowerment;Engineering;Environment;Equilibrium;experience;Exposure to;flexibility;Focused Ultrasound Therapy;Geometry;Goals;Health Technology;Heterogeneity;High Frequency Waves;Housing;Image;imaging facilities;improved;Internships;ischemic injury;Laboratories;Linear Models;Mathematics;Measurement;Medicine;Mentorship;Methods;migration;Modernization;Monitor;non-invasive monitor;Non-linear Models;novel;Operative Surgical Procedures;Organ;Patient Monitoring;Pediatric Hospitals;peer;Perfusion;pre-clinical;Predictive Analytics;Procedures;Process;programs;Research;Research Project Grants;research study;Resources;Running;Schools;signal processing;simulation;Speed;Students;summer internship;Supercomputing;Technology;Testing;Texas;Therapeutic procedure;Time;Training;Training Programs;transmission process;Travel;Ultrasonic wave;Ultrasonics;Ultrasonography;ultrasound;undergraduate research;undergraduate student;Universities;Work;Workplace

PROJECT_TITLE: Novel pseudo-differential methods to drastically increase computational speed and accuracy for biomedical ultrasound imaging and focusing

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: VILLANOVA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: VILLANOVA UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative This collaborative project utilizes synthetic organic chemistry, physical organic chemistry, and microbiological analysis to develop novel disinfectant compounds to combat pathogenic bacteria, and shed light on why bacteria can resist the traditional disinfectants that have been used for nearly a century. Moving beyond traditional structural classes of disinfectants that have become susceptible to bacterial resistance, we will develop fundamentally different structures that, when paired with careful analyses of their physical properties and solution behavior, will shape the next generation of antimicrobials.

PI_NAMEs: MINBIOLE, KEVIN P (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TITLE: The Development of Novel Disinfectants to Overcome Bacterial Resistance

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Individuals with type 2 diabetes (T2D) vary markedly from one another in terms of their clinical features and response to treatment, but efforts to identify subtypes of diabetes are limited and have not yet been translated into clinical care. Our proposal aims to advance prior approaches by combining multiple data types together – clinical features, genetic information, and metabolomic markers – to identify specific subtypes of T2D that can predict treatment response and disease complications. We also plan to develop and assess simpler versions of these novel T2D subtypes that can be easily used by clinicians with the ultimate goal of improving personalized care of patients with T2D.

PI_NAMEs: MERCADER, JOSEP MARIA;UDLER, MIRIAM SARGON (contact);UTZSCHNEIDER, KRISTINA MARIE

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Adolescent;Automobile Driving;biobank;Classification;Classification Scheme;Clinic;Clinical;clinical application;clinical care;Clinical Data;clinical practice;clinical risk;Clinical Trials;clinically relevant;cohort;Collection;comparative effectiveness study;Complication;Data;data integration;diabetes management;Diabetes Mellitus;diabetes prevention program;Diagnosis;Disease;disease heterogeneity;Disease Outcome;Disease Progression;Elements;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Etiology;Exclusion;Functional disorder;Generations;Genetic;genetic information;Genomics;Germ Lines;global health;Glucose;Goals;Health;Hyperglycemia;improved;Individual;Intervention;Laboratories;lifestyle intervention;Link;Longitudinal cohort;Machine Learning;machine learning method;Measures;Metabolic;metabolomics;Methods;Modeling;Multiomic Data;multiple data types;multiple omics;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome Study;Patient Care;patient subsets;Patients;Performance;personalized care;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;phenotypic data;Physical activity;Population Heterogeneity;precision medicine;Prediction of Response to Therapy;prevent;progression risk;Proxy;Randomized, Controlled Trials;Research;Research Design;response;Risk;Risk Factors;SEARCH for Diabetes in Youth;social health determinants;Standardization;targeted treatment;Time;tool;trait;Translating;treatment choice;treatment response;treatment strategy;United States;Youth

PROJECT_TITLE: GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung

PHR: NARRATIVE Asthma and chronic obstructive pulmonary disease (COPD) together are the largest causes of disability and death from chronic lung diseases worldwide. One of the key mechanisms causing both diseases is aberrant airway communication between the cells lining the airways in the lung (airway epithelial cells) and cells of the immune system, which leads to inflammation and remodeling of the lungs and airways. Our overall objective is to comprehensively define the signaling and spatial relationships between airway epithelial cells and airway immune cell populations in asthma and COPD to define therapeutic approaches that precisely target disease- specific mechanisms.

PI_NAMEs: DEGUINE, JACQUES ;MEDOFF, BENJAMIN DAVID (contact);RAJAGOPAL, JAYARAJ

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Affect;Airway Disease;airway epithelium;Allergens;Antigens;Architecture;Asthma;asthmatic;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Bioinformatics;bioinformatics tool;Biological Response Modifiers;Bronchoscopy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Line;Cell Separation;cell type;Cells;Cellular biology;Cellular Structures;Cessation of life;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Collaborations;Communication;Complex;Data;disability;Disease;disease phenotype;Epithelial Cells;Excision;Extrinsic asthma;Functional disorder;Genes;Genetic Transcription;genome wide association study;Heart;HLA Antigens;human disease;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunologics;Immunology;immunoregulation;In Situ;Inflammation;Inflammatory;innovation;Island;Lung;Lung Diseases;lung health;Lymphocyte;Lymphoid Tissue;M cell;Maps;Mediator;Methods;Microbe;Modification;mortality;Mucous Membrane;Myeloid Cells;Natural Immunity;Neuroendocrine Cell;novel;Operative Surgical Procedures;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Population;Positioning Attribute;Protocols documentation;Publishing;receptor;Recording of previous events;Respiration Disorders;response;Role;Sampling;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;spatial relationship;Specificity;Structure;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;tissue resident memory T cell;Tissues;transcriptomics;Transplantation;Variant

PROJECT_TITLE: Mapping Airway Epithelial Cell-Immune Cell Interactions in Lung Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: JAMAICA

ORG_NAME: YORK COLLEGE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Aggregation of serum amyloid A (SAA) and the formation of circulating amyloid fibrils is pivotal to the development of SAA amyloidosis which is a potentially life-threatening complication of chronic inflammatory diseases. The focus of this proposal is to experimentally determine the mechanism of SAA misfolding and compare it to recent theoretical models. A better understanding of the mechanism of SAA aggregation will lay the foundation for the development of potential therapeutic agents.

PI_NAMEs: DESAMERO, RUEL Z B (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Learning;Acute-Phase Proteins;alpha helix;Amino Acids;Amyloid;Amyloid Fibrils;Amyloidosis;Behavior;Binding;Biochemical;career;Chronic;chronic inflammatory disease;community college;Complication;Computer Analysis;computer studies;COVID-19;Critical Thinking;Data;Data Analyses;Deposition;design;Development;Disease;Education;Electrons;Electrostatics;Employment;Ensure;Exhibits;experience;experimental study;Failure;Fluorescence Resonance Energy Transfer;Fortification;Foundations;Funding;Goals;Group Meetings;high school;Hydrogen Bonding;Hydrophobicity;hydroxyl group;in silico;In Vitro;Inflammation;Inflammatory;Infrastructure;inhibitor;interest;Investigation;Kinetics;Knowledge;Label;Laboratories;Learning;Life;Methods;Modeling;Modernization;Molecular Conformation;molecular dynamics;monomer;Morphology;mutant;Mutate;Mutation;N-terminal;Organ;overexpression;Pathway interactions;peptide analog;Peptide Synthesis;Peptides;Play;Population;Positioning Attribute;Process;programs;Property;Proteins;Protocols documentation;Research;Research Personnel;Role;screening;self assembly;Serum amyloid A protein;Severities;Solid;spectroscopic data;Spectrum Analysis;Structure;student participation;Students;success;synthetic peptide;System;Technology;Theoretical model;theories;Therapeutic Agents;therapeutic target;Time;Tissues;Translating;undergraduate student;Underrepresented Minority;university student;validation studies;Work

PROJECT_TITLE: Investigating the role of helix-1 in the fibrillization of SAA1-76

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Cancer immune surveillance depends on the presentation of tumor antigens and priming of antitumor T cells by myeloid antigen presenting cells, eg. macrophages and dendritic cells. A strategy to engage myeloid cells in antitumor immunity based on recombinant, highly attenuated poliovirus has shown great promise in Phase-1 clinical trials in glioblastoma and melanoma. In this project, we will investigate means to enhance immune stimulatory signaling in myeloid cells by modulating glucose metabolism with metabolic modifiers.

PI_NAMEs: GROMEIER, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acute;Address;Agonist;Anabolism;Antigen-Presenting Cells;Attenuated;cancer cell;cancer immunotherapy;Cancerous;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;Characteristics;Chimera organism;Clinical;Clinical effectiveness;clinical investigation;clinical translation;Clinical Trials;Cross Presentation;cytokine;cytokine release syndrome;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;Disease remission;Energy consumption;Environment;Enzymes;Exhibits;Generations;Genetic;Glioblastoma;Glioma;Glucose;glucose metabolism;Glycolysis;Goals;Health;Heterogeneity;Human;Human poliovirus;Immune;immune activation;Immune response;Immunity;Immunocompetence;Immunologic Surveillance;Immunosuppression;Immunotherapy;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;Interferon alpha;Interferon Type I;Interleukin-6;Intrinsic factor;Invaded;IRF3 gene;Kinetics;knock-down;Link;Macrophage;Malignant Neoplasms;Mediating;Melanoma;Metabolic;Metabolism;Microglia;monocyte;Mus;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;NF-kappa B;novel;oncolytic virotherapy;Outcome;parent grant;parent project;Parents;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Phagocytosis;Phase I Clinical Trials;Phenotype;Poliomyelitis;Predisposition;prevent;Production;Property;Reaction;Receptor Activation;Recombinants;recruit;Recurrence;Repression;Research;Research Design;Research Project Grants;response;RNA replication;Role;Signal Transduction;Slice;small molecule;spatiotemporal;Specificity;T cell response;T-Lymphocyte;TBK1 gene;Therapeutic;Tissues;TNF gene;Toll-like receptors;Tropism;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Viral;viral RNA;Virotherapy;Virus Diseases;Warburg Effect

PROJECT_TITLE: Research Supplement to Promote Diversity in Health-Related Research


NIH_SPENDING_CATS: Bioengineering;Natural Products

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Principle Investigator/Program Director (Last, first, middle): Dong, Vy, M Project Narrative Transition metal catalysis has significantly transformed the methods in which medicines are discovered and prepared. This can be seen through Nobel prize-winning work on asymmetric hydrogenation, metathesis, and C-C coupling reactions. There remains a conscious effort to produce enantioselective transformations that occur with high selectivity and atom-economy in order to furnish enantioenriched biomolecules. By use of transition metal catalysts, chemists have uncovered the functionalization of C-H bonds that previously were deemed inert. A particular motif of interest for small-molecule and natural product design are nitrogen-containing heterocycles. These strained ring systems such as cyclopropenes, azetidines, and cyclobutanes, all have been exploited in medicinal chemistry for their physicochemical properties and applications as functional group bioisosteres. Our program has a strong interest in utilizing the transformative power of hydroacylation—a process where C-H bond activation occurs with C-C bond formation, to introduce a creative method for resolving chiral strained rings. This work would not only develop more efficient methods to access such privileged motifs, but simultaneously open the door to future synthetic strategies in this chemical space.

PI_NAMEs: DONG, VY M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: acyl group;Aldehydes;Alkenes;Amines;Area;azetidine;Carbon;Catalysis;catalyst;chemical synthesis;Chemicals;Complex;Conscious;Coupling;Creativeness;cyclic amine;Cyclization;Cyclobutanes;cyclopentanone;cyclopropene;design;Development;driving force;drug candidate;drug discovery;Drug Industry;Ethane;functional group;Future;Goals;Hydrogen;Hydrogen Bonding;Hydrogenation;improved;innovation;insight;interest;Isomerism;Ketones;large scale production;Lead;Ligands;Medicine;Metals;Methods;Modern Medicine;Molecular;Molecular Probes;Molecular Structure;Natural Products;Nitrogen;Nobel Prize;novel;Pharmaceutical Chemistry;Pharmaceutical Preparations;Process;professor;programs;Property;Reaction;Reporting;Research Personnel;scaffold;Site;small molecule;Structure;synthetic drug;System;Time;tool;Transition Elements;Work

PROJECT_TITLE: Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This project is relevant to public health, as it will foster a better understanding of the relative influences psychological, social, and epigenomic factors have on cLBP and will also give insight into the mechanism the drives racial disparities in cLBP. The proposed project is in response to NIAMS RFA-AR-20-001, Mechanistic Ancillary Studies to Ongoing Clinical Projects. This work lays the foundation for a long-term program of research in developing targeted interventions to reduce cLBP disability and improve outcomes for racial minorities.

PI_NAMEs: AROKE, EDWIN NGOMUEH (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Administrative Supplement;Affect;African American;age acceleration;Alabama;Ancillary Study;biomarker development;bisulfite sequencing;Black Populations;Black race;bone;Brain-Derived Neurotrophic Factor;calcification;career development;Caucasians;Chronic;Chronic low back pain;chronic pain;chronic painful condition;Clinical;Collagen;cost;Cysteine;decrease resilience;Development;disability;Disability outcome;Disabling;Discipline of Nursing;Discrimination;Disparity;Disparity population;DNA;DNA Methylation;DNA Sequence;doctoral student;Education;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;experience;Fibromyalgia;Fostering;Foundations;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Health;Heritability;Hydrocortisone;Hypermethylation;IFNGR2 gene;IL17C gene;Immune Response Genes;improved outcome;Individual;Inflammation;innovation;insight;Interleukin-10;International;Intervention;intervertebral disk degeneration;Knowledge;low socioeconomic status;Measures;Mental Depression;Mentors;Mentorship;Methylation;methylation pattern;minority investigator;Modification;Moods;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;NFKB2 gene;NR3C2 gene;Nursing Research;Opioid Receptor;Pain;Pain Free;pain outcome;parent project;Parents;Participant;Patients;peripheral blood;Persons;Pilot Projects;Postoperative Pain;Poverty;pre-doctoral;Productivity;programs;Promoter Regions;prospective;Protein Secretion;Proteins;psychologic;Public Health;Quality of life;Race;racial difference;racial discrimination;racial disparity;racial minority;racial population;receptor expression;Registered nurse;Research;research and development;Research Personnel;Research Project Grants;Research Training;resilience;response;RUNX1 gene;Sampling;Severities;social;social stigma;Spinal Fusion;Stress;Stressful Event;Students;symposium;Tissue-Specific Gene Expression;TNF gene;Training;Training and Education;Universities;Work

PROJECT_TITLE: Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back Pain


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Hematology;Human Genome;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Sepsis

ORG_CITY: Los Angeles

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This study uses existing data gathered for other research to determine if white blood cells have a special response to severe tissue damage. This will help us understand why the white blood cells of some critically ill patients behave very differently than in other patients. Ultimately this understanding may help scientists find new ways to support the beneficial effects of inflammation on wound healing and immunity, while avoiding the harm uncontrolled inflammation can cause.

PI_NAMEs: SILETZ, ANAAR EASTOAK (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Abdominal Abscess;American;Award;Biological;Blood;Blood Circulation;candidate identification;Cardiac Surgery procedures;Cardiopulmonary Bypass;Career Mobility;CEACAM1;Cell Physiology;Cell-Cell Adhesion;Clinical;clinically relevant;collagenase;Complex;Critical Illness;Data;Data Set;Deterioration;Development;Etiology;Exposure to;Extravasation;Funding;Future;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic Transcription;Goals;Human;human data;human RNA sequencing;Immune response;Immunity;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Investigation;Laboratories;Leukocytes;Methods;migration;Multiple Organ Failure;neutrophil;Neutrophil Collagenase;novel;Operative Surgical Procedures;Organ failure;Pathway interactions;Patients;Phenotype;Pneumonia;Professional Organizations;Prognosis;programs;Publishing;Recovery;Reporting;Research;Research Personnel;response;Role;Sampling;Scientist;secondary analysis;Sepsis;septic;septic patients;Septic Shock;Shock;single-cell RNA sequencing;Source;Specificity;Sterility;systemic inflammatory response;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Trauma;Trauma patient;Traumatic injury;Urinary tract infection;Work;wound healing

PROJECT_TITLE: Secondary Analysis of Existing Datasets to Define the Neutrophil Transcriptomic Response to Parenchymal Damage

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: PROVO

ORG_DEPT: BIOLOGY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: NARRATIVE The All of Us Research Program, with its comprehensive electronic health records and whole genome sequencing, promises a discovery-rich environment to compare and contrast the multifarious contributors to a cancer diagnosis. Using data from The Cancer Genome Atlas (TCGA) and other major cancer-genomics repositories, we will move beyond tumor-specific phenotypes and explore the whole individual to find novel links, comorbidities, and triggers that fill the gaps in predicting cancer occurrence. The All of Us Research Program provides an optimal environment to address cancer questions and train undergraduates to become the next generation of bioinformaticians because of its comprehensive ethics training, exposure to cloud infrastructure, and sound practices to generate reproducible code.

PI_NAMEs: BAILEY, MATTHEW H (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Age;Agreement;Algorithms;All of Us Research Program;anti-cancer research;biobank;Bioinformatics;Biological Factors;biomedical scientist;cancer biomarkers;cancer diagnosis;cancer genomics;Cancer Model;cancer predisposition;cancer type;career;Cause of Death;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical;clinical care;Cloud Computing;Code;cohort;Collection;Communities;comorbidity;Computational algorithm;Computer software;Computerized Medical Record;Creativeness;Data;Data Collection;Data Set;Databases;Demographic Survey;demographics;Development;Diagnosis;Diagnostic;diagnostic accuracy;Disease;disease model;diverse data;Electronic Health Record;Environment;environment related cancer;Environmental Risk Factor;Ethics;Event;Exercise;Exposure to;Funding;Genetic;genetic information;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome repository;genome sequencing;Genomics;Genotype;Germ-Line Mutation;Grant;Health;health assessment;health data;Healthcare;Healthcare Systems;Heritability;Hospitals;Human;human disease;improved;Incidence;Individual;innovation;insertion/deletion mutation;Insurance;large datasets;Lead;Link;Malignant Neoplasms;Maps;Measurement;Measures;Modeling;Molecular;Mutation;National Cancer Institute;Neoplasms;next generation;novel;Participant;Pathogenicity;Patient-Focused Outcomes;Patients;Persons;Phenotype;Population Heterogeneity;precision medicine;prediction algorithm;predictive tools;Preventive;prognostic;programs;Quality Control;recruit;Reporting;Reproducibility;Research;Resources;response;Rewards;Running;Screening for cancer;social factors;Socioeconomic Status;Somatic Mutation;sound;Statistical Models;Surveys;Survival Rate;Technology;The Cancer Genome Atlas;tool;Training;Treatment Protocols;trend;tumor;Tumor Subtype;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Variant;Visit;whole genome;Work

PROJECT_TITLE: Genetic predisposition and misdiagnosis of cancer in All of Us participants

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Autoimmune Disease;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Children and adults with type 1 diabetes (T1D) may develop declines in brain function over time, however, the causes of these declines are not well understood. In the proposed longitudinal study, we will evaluate children beginning at T1D diagnosis and over time using measurements of cognition, brain structure and metabolism, and systemic and neural inflammation. We will determine how diabetes-related variables such as glucose levels and glucose variability, exposure to diabetic ketoacidosis and episodes of hypoglycemia predict neurocognitive differences over time.

PI_NAMEs: GHETTI, SIMONA  (contact);GLASER, NICOLE S

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 11 year old;3-Dimensional;Accounting;Acute;Adult;Affect;Anisotropy;base;Biological Assay;Blood;Brain;Brain Injuries;brain magnetic resonance imaging;chemokine;Child;Childhood diabetes;Chronic;Clinical;clinical practice;clinical predictors;clinical research site;Cognition;Cognitive;Cognitive deficits;cognitive function;cohort;Collaborations;comparison group;Creatine;cytokine;Data;Dementia;density;Development;Devices;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diffusion Magnetic Resonance Imaging;Education;Enrollment;Ethnic Origin;Ethnic Population;Exhibits;experience;Exposure to;follow up assessment;Foundations;Frequencies;Fright;Future;Gene Expression;Glucose;glycemic control;Glycosylated hemoglobin A;Health;Human;Hybrids;Hyperglycemia;Hypoglycemia;Impaired cognition;improved;Income;Inflammatory;inflammatory marker;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Trial;Life;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Mediator;Metabolic;Metabolism;Methods;Modeling;Multicenter Studies;N-acetylaspartate;nerve injury;Neurocognitive;Neurocognitive Deficit;neuroinflammation;neuron loss;Neurons;Outcome;Participant;Persons;Phase;prevent;Prevention;primary outcome;prospective;protective factors;Protocols documentation;Race;racial diversity;racial population;Research;Risk;Risk Factors;RNA;Sampling;Serum;Socioeconomic Status;Structure;System;systemic inflammatory response;Testing;Time;time use;Underserved Population;white matter;white matter injury;Work

PROJECT_TITLE: Risk and Protective Factors for Neurocognitive Development in Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE PACIFIC UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: It is estimated that ~15% of cancers are caused by virus infections. Viruses are intracellular parasites which lack their own metabolism, so they must hijack host cell metabolic machinery to create more energy, proteins, fats, and genetic material necessary to replicate. This proposal seeks to identify clinically relevant ant-metabolic drugs to treat herpesvirus infections that cause cancer.

PI_NAMEs: DELGADO, TRACIE  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Affect;Amino Acids;Animal Model;Ants;Biological Assay;Biological Models;Cancer Etiology;Cell Death;Cell Line;Cell Proliferation;Cells;Cellular Metabolic Process;Cessation of life;chronic infection;Clinical assessments;Clinical Trials;clinically relevant;Computer software;Curiosities;Data;Data Set;drug metabolism;Drug toxicity;Educational process of instructing;Epstein-Barr Virus latency;Exhibits;experience;experimental study;Family;Fatty acid glycerol esters;Fatty Acids;FDA approved;Future;gammaherpesvirus;Gene set enrichment analysis;Genes;Genetic;Genetic Materials;Genetic Transcription;Glucose;Glutamine;Glycolysis;graduate school;Herpesviridae;Herpesviridae Infections;Human;Human Herpesvirus 4;Human Herpesvirus 8;In Vitro;Infection;inhibitor;insight;Kaposi Sarcoma;latent infection;Life Cycle Stages;lipid metabolism;lipidomics;Lipids;Lytic;Lytic Phase;lytic replication;Lytic Virus;Maintenance;Malignant Neoplasms;Measures;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Murine herpesvirus 68;Mus;novel therapeutics;nucleotide metabolism;Nucleotides;Oncogenic;Oncogenic Viruses;Open Reading Frames;Parasites;pathogen;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Plaque Assay;Population;Process;Production;Productivity;programs;Proteins;Publishing;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Rodent;Role;Students;System;Therapeutic;Time;transcriptome sequencing;Transmission Electron Microscopy;Transplant Recipients;tumor;tumorigenesis;undergraduate student;Universities;Viral;Viral Genes;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: The Identification of Clinically Relevant Metabolic Inhibitors to Treat Gammaherpesvirus Infections

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Narrative Proper control of cell division is crucial for the replenishment of hundreds of billions of blood cells on a daily basis. Mutations that disrupt the genetic machinery regulating cell division can cause cancer. This project would advance our understanding of the genetic machinery that stops cell division during the maturation of white blood cells.

PI_NAMEs: MANU, MANU  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute Erythroblastic Leukemia;ATAC-seq;Binding;Binding Sites;Blood;Blood Cells;Bromodeoxyuridine;Bypass;Cancer Etiology;CCAAT-Enhancer-Binding Proteins;CCND2 gene;CCNE1 gene;cdc Genes;CDK4 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Inhibition;Cell division;Cell Line;cell type;Cells;Cellular Structures;Cleavage Under Targets and Release Using Nuclease;Complex;CRISPR/Cas technology;Cyclin D1;Cyclin-Dependent Kinase Inhibitor;cyclin-dependent kinase inhibitor 1B;Cyclins;Data;Data Set;Development;Distal;DNA;Dye Dilution Technique;Effector Cell;Enhancers;Erythroid Cells;Etiology;Exhibits;experimental study;factor C;Family;G1/S Transition;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Hematopoiesis;Hematopoietic stem cells;in vitro Model;Individual;Interphase Cell;Label;Length;leukemia;leukemic stem cell;Leukocytes;loss of function;Macrophage;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Molecular;Mus;Mutate;Mutation;Myelogenous;Myeloid Cells;neutrophil;novel;Pathway interactions;Phenotype;Process;progenitor;promoter;proto-oncogene protein Spi-1;Regulation;Regulatory Element;repaired;Reporter;Reporter Genes;Resolution;Site;Site-Directed Mutagenesis;Specific qualifier value;stem cells;success;System;temporal measurement;Testing;Time;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumorigenesis

PROJECT_TITLE: The direct transcriptional regulation of cell cycle genes by cell identity factors during myeloid differentiation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: COLUMBIA

ORG_NAME: COLUMBIA INTERNATIONAL UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH The goal of this study is to understand the mechanisms of glucose sensing through the plasma membrane of yeast. The results of this research will provide significant insights into the processes involved in the maintenance of glucose homeostasis in humans, especially under pathological conditions, such as hyperglycemia in diabetics and the elevated rate of glycolysis observed in many solid tumors.

PI_NAMEs: KIM, JEONG-HO  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Biochemical;Biological Models;blood glucose regulation;Calcium Channel;cancer cell;cancer type;Carbon;Cell membrane;Cell Nucleus;Cell surface;Cells;cellular transduction;Complex;Consumption;Coupled;Cytoplasm;Cytosol;Defect;Diabetes Mellitus;diabetic;Diglycerides;Energy-Generating Resources;Eukaryotic Cell;extracellular;Family;Fermentation;Funding;Generations;Genes;genetic corepressor;Genetic Epistasis;Glucose;glucose metabolism;glucose receptor;Glucose Transporter;glucose uptake;Glycolysis;Goals;health goals;Human;Hyperglycemia;Impairment;inorganic phosphate;Inositol Phosphates;insight;Isoenzymes;Learning;Life Style;Lipids;Maintenance;Mediating;Metabolic Diseases;Metabolic Pathway;Metabolism;Modeling;neoplastic cell;Nutrient;Nutrient availability;Organism;Orthologous Gene;Pathologic;Pathway interactions;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase C;Play;Process;promoter;Proteins;Public Health;Pump;receptor;Receptor Signaling;Repression;Repressor Proteins;Research;response;Role;Saccharomyces cerevisiae;Second Messenger Systems;Signal Transduction;Signal Transduction Pathway;Solid Neoplasm;transcription factor;Yeasts

PROJECT_TITLE: Receptor-mediated glucose sensing in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative: Drugs of abuse cause addiction, negatively impact individuals, and costs the government ~$450 billion dollars/yr. in related expenses. In addition, the opiate epidemic has seen a 10-fold increase in opioid-caused deaths in the last 5 years, but unfortunately, we do not understand the full actions of opiates on the reward system and no selective treatment to alleviate addiction in general is available. We hope that by examining normal function in the brain’s reward center and more fully exploring morphine-induced negative impact in the reward circuit, it will provide a more complete picture for addiction treatment strategies.

PI_NAMEs: EDWARDS, JEFFREY G (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acute;addiction;Address;Admission activity;Adolescent;Adult;Alcohol abuse;Alcohols;Association Learning;Award;Behavior;Behavioral Mechanisms;Brain;Cause of Death;Cells;Chronic;combat;Complex;cost;Data;Dependence;Disease;Dopamine;dopaminergic neuron;Drug abuse;Drug Addiction;drug of abuse;Electrophysiology (science);Epidemic;Exhibits;experience;gamma-Aminobutyric Acid;Genetic;Goals;Government;Illicit Drugs;in vivo;Individual;innovation;Interneurons;Intraperitoneal Injections;Long-Term Depression;Long-Term Potentiation;Mediating;Methodology;Mission;Modification;Morphine;Motivation;Mus;National Institute of Drug Abuse;neural circuit;neuroadaptation;neurobiological mechanism;Neurobiology;Neurons;new therapeutic target;novel;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;Opioid Receptor;opioid use disorder;optogenetics;Output;Paint;Perception;Persons;Pharmaceutical Preparations;Pharmacology;Physiology;Predisposition;Rabies virus;Relapse;Research;Rewards;Role;Smoking;substance abuse treatment;Surveys;Synapses;Synaptic plasticity;synthetic opioid;System;Techniques;treatment program;treatment strategy;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Ventral Tegmental Area;Vision;web site

PROJECT_TITLE: Ventral Tegmental Area GABA Neurons: Plasticity & Opiate Receptors at InhibitoryInputs

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: POCATELLO

ORG_NAME: IDAHO STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE During early development, patterning of the embryo into separate domains is essential to ensure the correct size and placement of subsequent tissue formation; indeed, disruption of this process can lead to malformations of structures such as the craniofacial bones in human patients. Multiple members of the TGF signaling pathway, including BMP, are essential for patterning events. Here, we seek to determine the molecular function of the Masp1 protein in contributing to patterning of the embryonic ectoderm through intersection with BMP signaling with implications for our understanding of Masp1- associated developmental disorders.

PI_NAMEs: RAY, HEATHER JOY (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Methylcholanthrene;Acceleration;Address;Affect;African;Anterior;Biological Assay;Biological Models;Bone Morphogenetic Proteins;brain tissue;Candidate Disease Gene;Cell Physiology;Cells;Cementation;chordin;Clinical;clinical diagnosis;Co-Immunoprecipitations;Complement;Congenital Abnormality;craniofacial;craniofacial bone;craniofacial development;craniofacial tissue;Data;Defect;Development;Developmental Biology;developmental disease;Developmental Process;Disease;Disease Progression;DNA Sequence Alteration;Dorsal;Ectoderm;Education;Embryo;Embryonic Development;Ensure;Environment;Etiology;Event;experience;Family;Future;Gastrula;gastrulation;Gene Expression Profile;Gene Expression Profiling;Gene Mutation;Genes;Genetic;Genomics;Gland;Goals;graduate student;Growth Factor;Head;Human;Idaho;Impaired cognition;improved;In Situ Hybridization;in vivo;Individual;Innate Immune System;insight;Institution;Intervention;Investigation;knock-down;Knowledge;Lead;Link;liquid chromatography mass spectrometry;Luciferases;malformation;Mannose Binding Lectin;member;Modeling;Molecular;Mutation;neural;neurodevelopment;novel;Outcome;overexpression;Pathway interactions;Patients;Pattern;Phenotype;Positioning Attribute;prevent;Prevention;Process;Proteins;Regulation;Reporter;Reporting;Research;Research Personnel;response;Role;Serine Protease;Shapes;Signal Pathway;Signal Repression;Signal Transduction;Signaling Protein;skeletal tissue;Specific qualifier value;Structural Congenital Anomalies;Structure;Syndrome;Technology;Tissues;Training;transcriptome sequencing;undergraduate research;undergraduate student;Universities;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: Investigation of the serine protease Masp1 as a novel regulator of Bmp signaling during early embryonic development.


PHR: PROJECT NARRATIVE Our overarching goal is to integrate clinical and multi-omic data into prediabetes and type 2 diabetes classification and build prediction models of disease trajectories over the lifespan. Our central hypothesis is that multi-omic data can refine definitions of type 2 diabetes, identify those patients most like to develop complications, and better identify people at risk for future development of type 2 diabetes. Our approach is to apply sophisticated clustering in diverse, longitudinal cohorts over rich omics data to identify subgroups of individuals who develop type 2 diabetes.

PI_NAMEs: MANNING, ALISA KNODLE (contact);QI, QIBIN ;ROTTER, JEROME I;WOOD, ALEXIS CAROLINE

PROJECT_TERMS: accurate diagnosis;American;Biological;Biological Assay;Biological Markers;Blood Glucose;Blood Vessels;Cessation of life;Classification;Clinical;clinical biomarkers;Clinical Data;clinical phenotype;cohort;Collaborations;comorbidity;Complication;Data;design;Development;Diabetes Mellitus;diabetes risk;Diagnostic;diagnostic tool;Diet;Dietary intake;Disease;disease model;Electronic Health Record;Ethnic Population;Exercise;experience;fasting glucose;feature selection;Future;Genetic;Glucose;Glycosylated hemoglobin A;Goals;Heterogeneity;high dimensionality;improved;in vivo;Individual;Intervention;Lead;Life;life span;Life Style;lifestyle data;Link;Longitudinal cohort;macrovascular disease;Measures;Medical;metabolic profile;metabolomics;Molecular;molecular marker;multi-ethnic;Multiomic Data;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;Organ;Outcome;Participant;Pathway interactions;Patients;Pattern;personalized approach;personalized medicine;Pharmaceutical Preparations;Phenotype;phenotypic data;Physiological;Population;Populations at Risk;precision medicine;Prediabetes syndrome;predictive modeling;premature;prevent;Proteomics;Reproducibility;Resources;response;Retinal Diseases;Risk;risk prediction;Risk Reduction;risk stratification;Sleep;sleep quality;sleep quantity;Structure;Subgroup;theories;Time;trait;Translating

PROJECT_TITLE: Longitudinal omics-based trajectories of type 2 diabetes subtypes: the T2D Heterogeneity Consortium


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pediatric;Rehabilitation;Telehealth

ORG_CITY: MONTCLAIR

ORG_NAME: MONTCLAIR STATE UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative In the post-COVID era, adoption of telepractice delivery of speech intervention has continued to grow due to its greater flexibility and efficiency and its ability to enhance access to specialized services such as visual-acoustic biofeedback. The proposed research will meet a public health need by expanding our basic understanding of perception-production relations in child speech while evaluating whether tasks involving perceptual training and biofeedback intervention are valid in the online modality. This translational research aligns with NIDCD’s mission to improve the lives of individuals with communication disorders, as it will explore the relationship between auditory-enhanced treatments and expand evidence for the online delivery of biofeedback intervention to sibilants, an additional class of frequently misarticulated sounds.

PI_NAMEs: HITCHCOCK, ELAINE RUSSO (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adolescence;Adoption;Adult;Affect;Age;American;Articulation Disorders;Auditory;Auditory Perception;Biofeedback;Biofeedback Training;bullying;Categories;Child;Childhood;Classification;Clinical;Clinical Management;clinical translation;Clinical Trials Design;clinically significant;Communication impairment;COVID-19 pandemic;Data;Diagnosis;Disease;Education;efficacy evaluation;Empirical Research;Environment;evidence base;Exhibits;experience;Experimental Designs;Feedback;flexibility;Fourier Transform;Funding;Goals;improved;Individual;insight;Intervention;Measures;Methods;Mission;Modality;motor learning;National Institute on Deafness and Other Communication Disorders;Nature;new technology;online delivery;online resource;open data;Outcome;Output;Participant;Pattern;Perception;Persons;Positioning Attribute;post-COVID-19;Prevalence;Process;Production;Public Health;Publications;Randomized;remote delivery;Reporting;Research;Research Personnel;Residual state;response;Sampling;service delivery;Services;Shapes;Signal Transduction;social;sound;Speech;Speech Delay;Speech Development;Speech Disorders;Speech Intelligibility;Speech Pathology;Speech Perception;Speech Sound;Students;Testing;therapy design;Time;tool;Training;Translational Research;treatment effect;Treatment outcome;uptake;Visual;Vocation;Well in self;Work

PROJECT_TITLE: Online assessment and enhancement of auditory perception for speech sound errors

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative The project will establish a novel generation of personalized cardiac patch devices for remuscularization of heart with postinfarction LV remodeling, which is one of the most significant problem in public health. The central hypothesis is that the novel bioengineered and perfusable cardiac patch using novel hiPSC lines, can remuscularize the ischemic injured heart using minimally invasive technologies. The findings will have significant impact in diagnostic and treatment of heart failure, and improve the public health.

PI_NAMEs: SERPOOSHAN, VAHID ;ZHANG, JIANYI  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;3D Print;Achievement;Acute;Acute myocardial infarction;Adult;Angiogenic Factor;animal data;Apoptotic;Arrhythmia;bioink;Biomechanics;Biomedical Engineering;bioprinting;Bioreactors;Birth;Blood Vessels;BMP4;Cardiac;Cardiac Myocytes;cardioprotection;Catheters;CCND2 gene;cdc Genes;Cell Cycle;Cell Line;Cell Proliferation;Cell Surface Receptors;cell type;Cells;Characteristics;Chemicals;Chest;Chronic;Cicatrix;Clinical;clinical application;clinically relevant;comparative efficacy;Congestive Heart Failure;Coupling;Cues;Death Rate;design;Devices;Diagnostic;Dilatation - action;Echocardiography;effectiveness evaluation;Electric Stimulation;Encapsulated;Endothelial Cells;endothelial stem cell;Engineering;Engraftment;Epicardium;Face;Family suidae;Fibroblasts;Follistatin;Follistatin-Related Protein 1;Gadolinium;Gelatin;Generations;Geometry;Glycoproteins;glycosylation;Heart;Heart failure;heart function;Heart Injuries;Human Cell Line;human induced pluripotent stem cells;Hydrogels;implantation;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Infarction;Infusion procedures;Injections;Ischemia;ischemic cardiomyopathy;ischemic injury;knock-down;Label;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Left ventricular structure;Magnetic Resonance Imaging;Maps;Mediating;meter;Methacrylates;Methods;minimally invasive;Molecular;mouse model;Mus;Muscle;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;novel;Optics;overexpression;Patients;Perfusion;Pericardial body location;Periodicity;Pilot Projects;Population;porcine model;pre-clinical assessment;prevent;Printing;Process;Proliferating;promoter;Proto-Oncogene Proteins c-akt;Public Health;receptor;regeneration function;repaired;Reperfusion Therapy;Reporting;Resolution;response;Risk;Risk Reduction;Role;scaffold;Shapes;Signal Pathway;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Stretching;Surface;Technology;Testing;Therapeutic;Time;Tissue Model;Tissues;Transplantation;Treatment Protocols;Vascularization;Ventricular

PROJECT_TITLE: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: MH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative - Relevance  Using the Pavlovian fear conditioning paradigm, the proposed experiments outlined in this document will expand the current literature on the physiological underpinnings of fear memory storage. Enhanced understanding of the biological mechanisms underlying fear memory storage are important not only for increasing our basic knowledge of this process but also for the potential translation of research findings to both normal and disordered memory in humans.

PI_NAMEs: JAROME, TIMOTHY JOSEPH (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Amygdaloid structure;Behavioral Model;Binding;Biological;Biological Assay;Brain;Brain region;Cell Nucleus;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;conditioned fear;design;Development;Disease;DNA;DNA Methylation;DNMT3a;Emotional;Etiology;experimental study;fear memory;Female;Fright;Gene Expression;Genes;Genetic Transcription;Goals;Human;Impairment;in vivo;Knowledge;Learning;Literature;male;Mass Spectrum Analysis;Mediating;Memory;Memory Disorders;memory retention;Mental disorders;Methyl-CpG-Binding Protein 2;Methylation;Modeling;Molecular;multicatalytic endopeptidase complex;next generation;novel therapeutic intervention;Nuclear;Nuclear Protein;Pharmacology;Physiological;Polyubiquitination;Population;Post-Traumatic Stress Disorders;Predisposition;Process;Promoter Regions;Protein Biosynthesis;protein degradation;Proteins;Rattus;Regulation;response;Rodent;Role;sex;Sex Differences;Shock;Symptoms;System;Technology;Testing;therapeutic development;Training;Transcriptional Regulation;transcriptome sequencing;translational potential;Translational Research;Ubiquitin;ubiquitin mediated proteasome degradation;Ubiquitination;whole genome;Work

PROJECT_TITLE: The role of sex- and cell-type specific protein degradation increases in the amygdala in fear memory formation

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE There are no effective surgical strategies for the repair of volumetric muscle loss (VML) injuries. A nonsurgical strategy capable of restoring the muscle function that is lost to VML injury could improve the quality of life, enable a return to work, and ease the burdens associated with activities of daily living for thousands of people each year.

PI_NAMEs: WASHINGTON, TYRONE A (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Address;analytical method;Anti-Inflammatory Agents;Architecture;Attenuated;attenuation;Autologous;Biomedical Engineering;Cells;Chronic;Clinic;combinatorial;Cues;Data;efficacy evaluation;endurance exercise;Engineering;Environment;Etiology;Event;Exercise;exercise prescription;exercise training;experience;experimental study;Extracellular Matrix;Goals;Growth;Guidelines;Human;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Knowledge;lipid mediator;Measures;Medicine;Metabolism;Methods;Modality;Modeling;Muscle;Muscle Fibers;Muscle function;muscle regeneration;Muscle rehabilitation;Muscular Atrophy;Natural regeneration;novel strategies;Operative Surgical Procedures;Pathologic;Pathology;Performance;Persons;pharmacologic;Positioning Attribute;Quality of life;Rattus;Recovery;Recovery of Function;regenerative;regenerative approach;Regenerative capacity;Regenerative Medicine;regenerative repair;rehabilitation strategy;Rehabilitation therapy;repair strategy;repaired;Research;Resistance;response;Running;scaffold;Site;Skeletal Muscle;soft tissue;Stimulus;Techniques;therapeutically effective;Time;tissue repair;Tissues;tool;Training;Translating;treadmill;treatment strategy;volumetric muscle loss;Work

PROJECT_TITLE: Regenerative and Rehabilitation Strategies to Reduce Inflammation Following Volumetric Muscle Loss Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-Q (80)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: Leishmania parasites cause 0.7-1.3 million new cases and 50000-90000 deaths each year. Current treatments are inadequate and more research on Leishmania biology is needed to develop new drugs. The goal of this AREA grant is to better understand lipid metabolism in Leishmania and provide rigorous biomedical research training to undergraduate and graduate students at Texas Tech University.

PI_NAMEs: ZHANG, KAI  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acyltransferase;analog;Apoptosis;Area;biological adaptation to stress;Biology;Biomedical Research;Calcium;Cell Membrane Permeability;cell motility;Cells;Cessation of life;Chemicals;Cone;Country;design;Development;Differentiation and Growth;Disease;Disease Management;drug candidate;Enzymes;Eukaryota;Eukaryotic Cell;extracellular;Fatty Acids;Funding;Genetic;Glycerol;Glycerophospholipids;Goals;graduate student;Grant;Growth;Homeostasis;Infection;Inflammation;Insect Vectors;insight;Investigation;Lecithin;Leishmania;Leishmania major;Leishmaniasis;Life Cycle Stages;lipid metabolism;lipidome;lipidomics;Lipids;Lysophosphatidylcholines;Macrophage;Mammalian Cell;Mammals;Membrane;Metabolism;Midgut;Miltefosine;Minor;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Motility;mutant;new therapeutic target;novel therapeutics;Nutrient;Oral;overexpression;Parasites;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Phlebotominae;Phosphatidylethanolamine;phosphoethanolamine;Phospholipase A2;Phospholipase C;Phospholipases A;Phospholipid Metabolism;Plasmalogens;plasmenylethanolamine;Play;Process;Production;Proliferating;Publishing;Research;Research Training;Resistance;Role;Shapes;Signal Transduction;Sphingolipids;Sterols;Testing;Texas;Toxic effect;Training;undergraduate student;Universities;unpublished works;Vaccines;vector control;Vertebral column;Virulence

PROJECT_TITLE: Phospholipid metabolism in Leishmania

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LOS ANGELES

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

PHR: Narrative Parkinson's disease (PD) is a chronic and progressive movement disorder, affecting one million people in the U.S. Our goal is to investigate the interaction between alpha-synuclein aggregates and neuronal membranes, which is believed to play an important role in PD development and progression. Such information will facilitate the ultimate development of the PD treatment modality.

PI_NAMEs: WANG, YIXIAN  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Affinity;alpha synuclein;Atomic Force Microscopy;Binding;Biological Assay;cell fixing;Cell membrane;Cell Membrane Proteins;Cells;Chronic;Circular Dichroism;cytotoxic;cytotoxicity;Data;Development;Dopamine;dopaminergic neuron;drug development;Elements;Evaluation;Fluorescence;Functional disorder;Funding;Goals;Image;In Vitro;insight;Iron;Kinetics;Length;Lipid Bilayers;live cell imaging;Mass Spectrum Analysis;Measurement;Mediating;Membrane;Methodology;Microscopy;Modality;Molecular;Monitor;monomer;Movement Disorders;neuroblastoma cell;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;novel;Onset of illness;Outcomes Research;oxidation;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Persons;Phase;Phosphorylation;Phosphotransferases;Physiological;Plastics;Play;pre-formed fibril;presynaptic;Production;Proteins;real time monitoring;real-time images;Research;Resolution;Role;scanning ion conductance microscopy;Site;Substantia nigra structure;Surface Plasmon Resonance;targeted treatment;Techniques;Toxic Environmental Substances;Variant;Visualization;wasting;Work

PROJECT_TITLE: PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPY

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Many cancer survivors experience challenges in performing daily activities and loss of work productivity due to the adverse effects of cancer and its treatments, resulting in financial burdens for both individuals and society. The overarching goal of this U34 Clinical Trials Planning Grant is to gather information regarding the feasibility of and barriers to implementing a remotely delivered exercise intervention in a diverse population of cancer patients, as well as to gain insight into the population of cancer patients most like to exercise a decline in function as a result of cancer treatment. Study results will be used to inform the development of a Phase III trial to assess the efficacy of an efficient technology-enabled exercise oncology intervention to prevent the decline in physical function often observed in patients receiving chemotherapy, toward the goal of increasing the capacity for full employment after cancer treatment.

PI_NAMEs: LIGIBEL, JENNIFER A. (contact);SCHMITZ, KATHRYN H.

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adherence;Adverse effects;Advocate;Aerobic Exercise;American;American Cancer Society;American Society of Clinical Oncology;arm;base;Breast Cancer Patient;cancer diagnosis;Cancer Patient;cancer prevention;Cancer Survivor;cancer therapy;Caregivers;Caring;Characteristics;chemotherapy;Clinic;Clinical;Clinical Trials;cohort;Communities;Community Clinical Oncology Program;cost;Databases;Development;Diagnosis;disability;Disability Evaluation;disability payment;Disability prevention;disabled;Disease;Effectiveness;efficacy evaluation;eligible participant;Employment;Enrollment;Ensure;ethnic minority;Ethnic Origin;Evaluation;Exercise;exercise intervention;exercise prescription;exercise program;experience;Family;Financial Hardship;functional decline;functional loss;Goals;Grant;Guidelines;Health;Home;implementation barriers;improved;Individual;information gathering;insight;Intervention;intervention delivery;intervention program;Intervention Trial;Interview;low socioeconomic status;Malignant Neoplasms;Measures;Minority;minority patient;Morbidity - disease rate;Nurses;Oncology;Outpatients;participant enrollment;patient population;Patient Self-Report;Patients;Perception;Phase;phase III trial;Physical Function;physical impairment;Physicians;Pilot Projects;Population;Population Heterogeneity;Positioning Attribute;preservation;prevent;Productivity;programs;Qualifying;Race;racial minority;Recommendation;remote delivery;Research;resistance exercise;Risk;Rural;rural area;screening;Security;Site;Societies;socioeconomics;Structure;success;Survival Rate;Tablets;Technology;telehealth;Testing;Time;Treatment Side Effects;trial planning;Underserved Population;United States Social Security Administration;Update;uptake;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Distance-based Exercise to preserve Function and prevENt Disability (DEFEND)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE The overall goals of this research are to develop novel and high-impact statistical and computational tools to address some of the key analytical challenges in joint modeling of bulk-tissue and single-cell sequencing data. These methods will enable biomedical scientists to simultaneously characterize multi-level genomic variations and to accurately disentangle within- and between-subject cellular heterogeneity. The successful completion of the project will greatly facilitate the translation of basic research findings into clinical studies of human disease and have substantial implications for diagnosis and prognosis.

PI_NAMEs: JIANG, YUCHAO  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Basic Science;bioinformatics tool;Biological;Biomedical Research;biomedical scientist;cell type;Cells;Clinical;Clinical Research;Collaborations;Communities;computerized tools;Computing Methodologies;Data;Data Analyses;Diagnosis;DNA;epigenomics;Experimental Designs;genomic variation;Genomics;Goals;Heterogeneity;human disease;Joints;laboratory experiment;Methods;Modeling;Morphologic artifacts;multimodality;multiple omics;next generation sequencing;novel;open source;open source tool;Population;Prognosis;programs;Research;Research Personnel;RNA;single cell sequencing;Statistical Methods;statistics;technology development;Testing;Tissues;transcriptome sequencing;transcriptomics;Translations;Variant

PROJECT_TITLE: Statistical Methods for Bulk-Tissue and Single-Cell Multi-Omics Integration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: CHARLOTTE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: Project Narrative Often a social activity, problematic alcohol use (PAU) poses significant health problems in college students and may best be remedied by others intervening to stop this harmful behavior (bystander intervention). We currently do not understand why, when, and where PAU bystander intervention happens, because we currently have no way of assessing bystander behaviors in these situations. The proposed project extends our team's current work by finalizing the development of measures of PAU bystander behaviors across our recently developed Bystander Intervention for Problematic Alcohol Use Model (BIPAUM) and statistically testing the BIPAUM.

PI_NAMEs: MENNICKE, ANNELISE ;MONTANARO, ERIKA ANN (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Alcohol abuse;Alcohol dependence;alcohol use disorder;assault;Behavior;binge drinking;Cessation of life;Code;college;Data;data cleaning;data dissemination;data management;design;Development;drinking;effective intervention;Environment;ethnic minority;Evaluation;Event;Factor Analysis;Feedback;Focus Groups;Frequencies;Funding;Gender;Health;high risk population;Interpersonal Violence;Intervention;intervention program;Interview;longitudinal analysis;Measurement;Measures;Mentors;minority student;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nature;North Carolina;novel;Outcome;Outcome Assessment;peer;Population;prevent;Prevention approach;Primary Prevention;Property;Psychometrics;racial minority;recruit;Research;response;Sampling;sexual assault;sexual minority;social;student athlete;Students;Surveys;Testing;therapy development;undergraduate student;Universities;university student;Validation;Work

PROJECT_TITLE: Development and Validation of Remaining Measures to Assess the Bystander Intervention for Problematic Alcohol Use Model (BIPAUM)

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Nanotechnology

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSICS

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Encapsulating drugs in polymer nanoparticles is a common strategy for improving their bioavailability, but there is currently a significant gap in our fundamental understanding of the formation process, leaving much of the development and optimization reliant on qualitative assessments and trial-and-error methods. This project aims to develop a general model for the creation of drug-encapsulated nanoparticles while also providing valuable training opportunities for multiple undergraduate students in a highly multidisciplinary domain, thereby contributing to the education of future drug development researchers. Anticipated outcomes include the formulation of design principles that will serve as a blueprint for a diverse spectrum of nanoparticle drug formulations, addressing a wide array of medical conditions.

PI_NAMEs: VAN KEUREN, EDWARD  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Area;Biochemistry;biocompatible polymer;Biodistribution;Biological Availability;Biology;Biomedical Research;Chemistry;Chromatography;Computer Simulation;contrast imaging;Contrast Media;Dependence;Descriptor;design;Development;Diagnostic;diagnostic platform;Discipline;Drops;drug development;Drug Formulations;Drug Kinetics;Education;Encapsulated;Excipients;experience;Formulation;Future;Glass;imaging modality;improved;Interdisciplinary Study;Investigation;Kinetics;Learning;Liquid substance;Magnetic Resonance Imaging;Measures;Medical;Mentors;Methods;Modeling;Molecular;Morphology;multidisciplinary;nano;nanocapsule;nanocarrier;nanodrug;nanoformulation;nanometer;nanoparticle;nanoparticle drug;nanopolymer;novel therapeutics;Outcome;Output;Oxidative Stress;particle;Particle Size;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physics;Polymers;Precipitation;predictive modeling;Process;Property;Protocols documentation;Reactive Oxygen Species;Reporting;Research;Research Personnel;self assembly;Shapes;small molecule;Solubility;solute;Solvents;student training;Students;Surface;System;Techniques;Temperature;Testing;theories;Therapeutic;therapeutic nanoparticles;Thermodynamics;Time;Training;training opportunity;ultrasound;undergraduate student;Water;Work

PROJECT_TITLE: Investigations of drug encapsulation in polymer nanoparticles: Training undergraduate students in multidisciplinary research

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Preeclampsia is one of the most common pregnancy complications and involves high blood pressure and organ damage late in pregnancy. This project seeks to understand why women who survive preeclampsia have a much higher risk of developing heart disease after pregnancy, using new animal models of preeclampsia to examine how inflammation plays a role in the long-term process. The ultimate goal is to identify novel targets and treatments for women after preeclampsia to prevent future disease.

PI_NAMEs: BIWER, LAUREN ALYSSE (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adenoviruses;Adipose tissue;Adoptive Transfer;Affect;Angiogenesis Inhibitors;Angiotensin II;Animal Model;Animals;Antigen Presentation;Antigen Receptors;Antigens;Area;Arteries;Automobile Driving;Biology;Blood Pressure;Blood Vessels;C57BL/6 Mouse;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;CD3 Antigens;CD8B1 gene;cell motility;Cells;chemokine;Clinical;cytokine;Data;Dietary Sodium;Disease;End stage renal failure;Environment;epidemiologic data;Evaluation;Exhibits;Exposure to;Female;Flow Cytometry;Future;Goals;Heart Diseases;high risk;Human;Hypertension;hypertensive;Hypoxia;Immune;Immunologic Techniques;Immunology;improved;In Vitro;Infiltration;Inflammation;Inflammatory;Injury;insight;KDR gene;Kidney;kidney cell;Knowledge;Link;Lymphoid;Lymphoid Tissue;male;Maternal Health;Maternal Mortality;Maternal Physiology;Measures;Mediating;Medical center;Mentors;migration;Mission;Modeling;Monoclonal Antibody HuM291;Mus;Myocardial Infarction;Nephrology;novel;Organ;overexpression;Pathogenesis;Phenotype;Placenta;Population;post pregnancy;Postpartum Hypertension;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;prevent;Process;Production;PTPRC gene;Publishing;RANTES;Research Personnel;Resistance;response;Risk;Role;Secondary Hypertension;SELL gene;Sodium Chloride;Stimulus;Stress;Stroke;Structure;Syndrome;systemic inflammatory response;T cell infiltration;T cell therapy;T memory cell;T-Cell Depletion;T-Lymphocyte;Techniques;Testing;Training;training opportunity;United States National Institutes of Health;Universities;Vascular Diseases;Vascular remodeling;vasoconstriction;Vasodilation;Woman;women's treatment

PROJECT_TITLE: Mechanisms of post-preeclampsia hypertension

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project narra�ve N/A. See parent award.

PI_NAMEs: LAVETTI, KURT  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Child Health;Disparity;Infant Health;parent project;Social status;Workplace

PROJECT_TITLE: Impacts of Parental Workplace Social Status on Disparities in Infant and Child Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hematology;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Sepsis

ORG_CITY: NEW YORK

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: Project Narrative: Proteins driving cellular death programs contribute to inflammation underlying tissue injury during infectious diseases. How they contribute in different cells to dictate protective versus injurious inflammation remains unresolved. We hypothesize that during critical illness or sepsis some members of cellular death programs contribute to essential protective inflammation, whereas other members emerge as potential therapy targets as they drive injurious inflammation.

PI_NAMEs: MANDAL, PRATYUSHA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abnormal Cell;Acute;Affect;Anti-Inflammatory Agents;antimicrobial;Apoptosis;Apoptotic;Automobile Driving;Bacteremia;Bacteria;Bacterial Infections;Biological;Blood Vessels;CASP8 gene;Caspase;Cell Death;Cell Death Signaling Process;Cells;Cellular Structures;Cessation of life;chemical release;Chemicals;chemokine;Communicable Diseases;Critical Illness;cytokine;Data;Data Analyses;Data Set;defense response;defined contribution;design;Disease;Endothelial Cells;Endotoxemia;Epithelial Cells;Escherichia coli;Experimental Designs;Fibroblasts;Future;Genetic;Gram-Negative Bacteria;Grant;Health;Human;Immune;Immunity;immunogenic;Immunology;Infection;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;injury and repair;Interferons;Interleukin-6;Intervention;Invaded;knock-down;Knock-out;Knowledge;Lung;Macrophage;Manuscripts;Mediating;Mediator;Medical;member;Modeling;Molecular;monocyte;multiorgan injury;Mus;Mutant Strains Mice;Natural Immunity;next generation;novel;novel therapeutics;Organ;particle;pathogen;Pharmaceutical Preparations;Physiological;Play;Pneumonia;Population;Preparation;prevent;Process;Production;programs;Protein Kinase Interaction;Proteins;Pseudomonas aeruginosa;Pulmonary Inflammation;Receptor-Interacting Protein;Research;Research Personnel;Research Proposals;response;RIPK1 gene;RIPK3 gene;Role;Sepsis;Signal Transduction;Smooth Muscle Myocytes;Suppressor-Effector T-Lymphocytes;symposium;Systemic disease;Systemic infection;targeted treatment;Testing;Therapeutic;tissue injury;tissue repair;Tissues;TNF gene;Training;undergraduate student;Vertebrates;Work

PROJECT_TITLE: Cell Death Programs as Fundamental Drivers of Inflammation and Multi-Organ Injury

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Foodborne Illness;Mental Health;Neurosciences

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

PHR: Narrative The increased frequency and severity in cyanobacterial harmful algal blooms has resulted in the increased presence of toxic microcystins (MCs) freshwater sources used for drinking water. Recently, we found that sub- chronic ingestion of non-lethal MC-LR levels caused the stress response in mice to be maladaptive, which may trigger non-physiological conditions favorable for anxiety or depression. Here, we probe whether maternal ingestion of MC-LR disrupts the formation and function of the stress response in the offspring, with the goal to elucidate how ingestion of environmental MCs may cause generational deficits in the stress response.

PI_NAMEs: CHUNG, WILSON  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accidents;Acute;Adrenal Glands;Adult;Adult Children;Affect;Amygdaloid structure;anthropogenesis;Anxiety;Apoptosis;Area;Arginine;biological adaptation to stress;Body Weight Changes;Brain region;brain size;Cell Proliferation;Climate;clinically significant;contaminated drinking water;Corticosterone;Corticotropin;Corticotropin-Releasing Hormone;Cyanotoxin;Data;Dermal;design;Development;drinking water;Embryo;Embryonic Development;Environment;Eutrophication;Evaluation;Excision;Exposure to;Fatty acid glycerol esters;Feedback;Frequencies;Fresh Water;Future;Global Warming;Glucocorticoid Receptor;Glucocorticoids;Glucose;glucose tolerance;Goals;gut microbes;gut microbiome;harmful algal blooms;Health;Hippocampus;Homeostasis;Hour;Hypothalamic structure;Image Analysis;Immunofluorescence Immunologic;in utero;Ingestion;Inhalation;Learning;Leucine;Link;Lipid Peroxidation;Location;male;Mammals;mature animal;Measures;Memory;Mental Depression;Mental Health;Metabolic;metabolic rate;microbial community;microbiome;microcystin;Molecular Analysis;Mus;neurochemistry;Neurohormones;Neurons;neurotoxicity;Neurotransmitters;offspring;paraventricular nucleus;Peripheral;Physical activity;Pituitary Gland;Pituitary-Adrenal System;Placenta;Plants;postnatal;predictive modeling;Pregnancy;prenatal;Production;Rattus;receptor expression;Reporting;Research;research facility;Research Training;restraint stress;Severities;Source;Stress;stressor;Students;System;Temperature;Testing;Thinness;Tissues;tool;Toxic effect;Toxin;trophoblast;undergraduate research;undergraduate student;Vasopressins;Water;water treatment;Work

PROJECT_TITLE: The impact of maternal cyanotoxin ingestion on the development and function of the stress axis in offspring

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_CITY: MEMPHIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Despite the availability of antibiotics and other therapies, the mortality and hospitalization of patients with severe sepsis increased rapidly, causing approximately 200,000 annual deaths in the United States alone. Our proposed studies are designed to delineate the molecular mechanisms of sepsis development and aim to provide a novel therapeutic approach for septic shock.

PI_NAMEs: CHEN, GUOYUN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abbreviations;Animal Model;Antibiotics;antimicrobial;Bacteremia;Bacteria;Bacterial Infections;Binding;Cause of Death;cecal ligation puncture;Cell Surface Receptors;Cessation of life;Clinical;clinically relevant;COVID-19;Death Rate;design;Development;effective therapy;Elderberry;Escherichia coli;Exhibits;extracellular;Family;Fluorescence;Gram-Negative Bacteria;Gram-Positive Bacteria;Hospitalization;Human;Immune;Immune response;Immune system;Immunoglobulins;Immunoprecipitation;Incidence;Infection;Innate Immune Response;Intraperitoneal Injections;ITIM;Knock-out;Knockout Mice;Lectin;Lectin Receptors;Link;Lipopolysaccharides;lipoteichoic acid;Listeria monocytogenes;Maackia amurensis;Mediating;member;migration;Molecular;mortality;mouse model;Mus;neutrophil;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Orthologous Gene;pathogen;Patients;Positioning Attribute;Predisposition;prevent;Production;Publishing;Reactive Inhibition;Reactive Oxygen Species;Regulation;Reporting;response;Role;Sambucus nigra;Sepsis;Septic Shock;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Site;Staphylococcus aureus;Systemic Inflammatory Response Syndrome;targeted treatment;Testing;therapeutic target;Toll-like receptors;Tyrosine;United States;Wild Type Mouse

PROJECT_TITLE: The molecular mechanism of Siglec-E in bacterial clearance


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Cardiovascular disease is a leading cause of death worldwide and in the USA with this due to two key underlying reasons: 1.a progressive disease called atherosclerosis and 2.thrombosis. The adequate localization of therapeutics to atherosclerotic plaque or thrombi remains a challenge for current therapies. My goal is to study the targeted delivery of therapeutics to atherosclerotic plaque and thrombi, using cell-mediated therapeutic delivery coupled with next-generation nanoparticle synthesis technologies.

PI_NAMEs: MAIOCCHI, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Accounting;Address;Aging;Antioxidants;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;Biological;Blood coagulation;Cardiovascular Diseases;cardiovascular disorder therapy;Cause of Death;Cells;Cessation of life;Clinical;clinical translation;Coagulation Process;Coupled;Dangerousness;delivery vehicle;Disease;Disease Progression;Dose;Drug Delivery Systems;Drug Targeting;Encapsulated;Enzymes;Exhibits;FDA approved;folate-binding protein;Folic Acid;Formulation;Generations;Goals;Health;Hemorrhage;Immune;immune cell infiltrate;Immunologics;improved;In Vitro;in vivo;Infiltration;Inflammatory;innovation;Intervention;Investigational Therapies;Learning;Ligands;Macrophage;manufacture;Mediating;Mentorship;Methods;Modeling;monocyte;mouse model;nano;nanoencapsulated;nanoparticle;nanoparticle delivery;nanopolymer;Nanotechnology;neutrophil;new technology;next generation;novel;overexpression;Oxidative Stress;Penetration;Pharmaceutical Preparations;pharmacologic;Phase;Polymers;Precipitation;prevent;Procedures;Process;Production;Progressive Disease;Proteins;receptor internalization;Recruitment Activity;Research;RNA;Site;targeted delivery;Techniques;Technology;Testing;Therapeutic;Thrombosis;Thrombus;Time;Translations;Treatment Efficacy;vascular injury;Venous Thrombosis

PROJECT_TITLE: Targeted drug delivery for the treatment of cardiovascular disease and its clinical complications


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: MERCED

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE Candida albicans is among the most common fungal pathogens of humans, causing debilitating and life- threatening infections, especially in immunocompromised individuals. C. albicans can switch reversibly between two distinct pathogenic cell types – white and opaque – however the genes that underlie the unique virulence attributes of the opaque cell type are largely unknown and fundamental questions remain regarding the molecular mechanisms that govern switching between these two cell types. This proposal seeks to understand the role of white-opaque switching in C. albicans virulence and to uncover fundamental mechanisms that enable the heritable maintenance of the opaque cell type across hundreds of generations.

PI_NAMEs: HERNDAY, AARON D (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Adhesions;Animal Model;Behavior;Binding;Candida albicans;Candidiasis;Cell Differentiation process;Cell division;Cell Nucleus;cell type;Cells;Characteristics;Chimeric Proteins;Chromosomal Rearrangement;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;cost;Daughter;Death Rate;differential expression;Disease Progression;Disseminated candidiasis;DNA Sequence;Ectopic Expression;Enhancers;Epithelium;Eukaryota;experience;Fission Yeast;Fluorescence;fluorescence imaging;fungus;Gastrointestinal tract structure;Generations;Genes;genetic approach;Genetic Transcription;Genome;genome editing;genome-wide;Green Fluorescent Proteins;Growth;Heritability;Hospitals;host colonization;Human;human microbiota;human pathogen;Immunocompromised Host;In Vitro;Individual;Infection;Infectious Skin Diseases;Inherited;insight;Intercistronic Region;Invaded;Invertebrates;Knowledge;Label;Leukocytes;Libraries;Life;Liquid substance;Maintenance;Measures;member;Modeling;Molecular;Molecular Genetics;Monitor;Mothers;Mucous Membrane;Mus;mutant;Mycoses;novel;Nuclear;Oral;Organism;Output;Pathogenesis;pathogenic fungus;Pathogenicity;personalized approach;Phase;Phenotype;Physical condensation;Planarians;Play;programs;Proteins;red fluorescent protein;Reporter;Research Personnel;Resolution;Role;Saccharomyces cerevisiae;Saccharomycetales;segregation;Shapes;Skin;skin damage;Systemic infection;Testing;Transcript;transcription regulatory network;Transcriptional Regulation;ultra high resolution;undergraduate student;urogenital tract;Vertebrates;Virulence;virulence gene;Virulent;Work;Yeast Model System

PROJECT_TITLE: Candida albicans phenotypic switching: Transcriptional regulation and virulence attributes


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: LANCASTER

ORG_NAME: FRANKLIN AND MARSHALL COLLEGE

ORG_STATE: PA

PHR: Project Narrative The negative regulation of inflammation is necessary to prevent an overzealous response. Perturbations in the balance of an appropriate response, either too aggressive or attenuated, underlie immunopathology, transformation and chronic metabolic syndrome. Understanding the molecular mechanisms of negative regulation of inflammation will be necessary for the generation of new strategies to improve health.

PI_NAMEs: DAVIS, BECKLEY K (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: adaptive immunity;Affect;Attenuated;Autoimmune Diseases;Autoimmunity;base;Binding;Biochemical;Biochemistry;Biological;Biological Response Modifiers;CASP1 gene;Cell Death;Cell Line;Cells;Cellular biology;Chronic;Complex;Confocal Microscopy;Coupled;CRISPR/Cas technology;cytokine;Cytosol;design;Development;Disease;Disparate;ds-DNA;Endoplasmic Reticulum;Epithelial Cells;Equilibrium;Family;FMNL1 gene;Generations;Genetic Transcription;genetically modified cells;Germ Lines;Goals;Health;Host Defense;IGF1R gene;IL18 gene;Immune;Immune signaling;Immunity;Immunologics;immunopathology;improved;Infection;Inflammasome;Inflammation;Inflammatory;innate immune mechanisms;insight;Insulin-Like Growth Factor I;Interferon Type I;Interleukin-1 beta;Leucine;Leucine-Rich Repeat;Link;Location;Macrophage;Malignant Neoplasms;Mediating;Metabolic Diseases;Metabolic syndrome;Molecular;Molecular Probes;N-terminal;Natural Immunity;NF-kappa B;novel;Nucleic Acids;Nucleotides;overexpression;pathogen;Pathogen detection;Pathway interactions;Patients;Pattern;Pattern Recognition;Pattern recognition receptor;Phenotype;PIK3CG gene;prevent;Production;Protein Binding Domain;protein function;protein protein interaction;Proteins;Publishing;receptor;Receptor Signaling;Recombinants;recruit;Regulation;Resolution;response;RNA Interference;Role;Scaffolding Protein;screening;Series;Signal Pathway;Signal Transduction;Signaling Molecule;small hairpin RNA;spatiotemporal;T-Cell Receptor;Techniques;TRAF6 gene;trafficking;tumorigenesis;Wegener's Granulomatosis;yeast two hybrid system;Yeasts

PROJECT_TITLE: Regulation of pathogen sensing and inflammation by NLR proteins


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Smooth muscle cells (SMCs) play major roles in atherosclerosis, a leading cause of cardiovascular disease (CVD). Recent studies, including ours, applying SMC-lineage tracing murine models, human atherosclerosis plaques, and single-cell RNA sequencing (scRNA-seq), revealed novel SMC-derived cells during progression of atherosclerosis. The research outlined in this proposal aims to reveal molecular mechanisms governing a novel SMC-derived cell type in atherosclerosis and modulating functions of this cell type in established atherosclerosis and during disease regression, which will contribute to critical efforts to identify and understand novel molecular and cellular targets for prevention and treatment of atherosclerotic CVD.

PI_NAMEs: PAN, HUIZE  (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Acceleration;Address;advanced disease;Advisory Committees;antagonist;Apoptosis;Applications Grants;Area;Arterial Fatty Streak;atheroprotective;Atherosclerosis;Attenuated;Award;Biochemical;Cardiovascular Diseases;career;career development;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;cellular targeting;Complex;Data;design;Development;Disease Progression;Disease regression;Endothelial Cells;Epigenetic Process;epigenetic regulation;Equilibrium;EZH2 gene;Fibroblasts;Gene Expression;gene repression;Genes;Genetic Markers;Genomics;histological stains;Human;Immunoprecipitation;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Investigation;Leadership;Lesion;Link;Liver X Receptor;Macrophage;Manuscripts;Mass Spectrum Analysis;Mediating;migration;Molecular;Molecular Target;monocyte;mouse model;Mus;Necrosis;novel;Pathway interactions;Phase;Phenotype;Play;Preparation;Prevention;Program Development;promoter;Regulation;Repression;Research;Research Personnel;Research Training;response;Retinoic Acid Receptor;Role;RXR;Signal Repression;Signal Transduction;single-cell RNA sequencing;skills;Smooth Muscle Myocytes;stem cell biomarkers;stem cells;Stimulus;Techniques;Testing;Thick;Time;transdifferentiation;translational potential;Tretinoin;vascular smooth muscle cell proliferation;western diet;Work

PROJECT_TITLE: Genomic Regulation and Translational Potential of a Novel Smooth Muscle Cell-Derived Cell Type in Atherosclerosis


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

ORG_STATE: NY

PHR: Relevance to public health: The effective transport of drugs across biological membranes is critical to their ability to reach their target tissues from the site of administration, and particularly important for the potency of drugs with intracellular targets. While our knowledge of the role of active transport proteins in drug transport, the role of membrane proteins in mediating the passive flux of drugs is far less complete. These studies will hopefully she further light on the potential role of ion channels in mediating the movement of small molecule drugs across biological membranes.

PI_NAMEs: SAMWAYS, DAMIEN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: ABCB1 gene;absorption;Acids;Active Biological Transport;Address;Agonist;analog;antagonist;base;Biological;Blood Vessels;Calcium-Activated Potassium Channel;Carrier Proteins;Cations;cell growth;Cell Line;Cell membrane;Cell Membrane Permeability;cell type;Cells;Characteristics;Charge;Connexin 43;Diffusion;DNA Binding;Drug Delivery Systems;Drug Design;Drug Efflux;Drug Kinetics;Drug Transport;Dyes;Electrophysiology (science);Epithelial Cells;Epithelium;Exhibits;experimental study;extracellular;fluorescence imaging;fluorophore;follow-up;Goals;Growth;Hour;Image;Influentials;inhibitor;Intestines;Ion Channel;knock-down;Knowledge;Light;Link;lipid solubility;Malignant Neoplasms;Measures;Mediating;Membrane;membrane flux;Membrane Potentials;Membrane Proteins;Membrane Transport Proteins;Modeling;Movement;neoplastic cell;Nuclear;passive transport;patch clamp;Pathway interactions;Penetration;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phospholipids;Physiological;Plasma Cells;Plasmids;Play;Process;protein transport;Proteins;Public Health;receptor;recruit;Reporting;Resistance;Role;Route;Saline;Site;Skin;Small Interfering RNA;small molecule;solute;Stains;Testing;Therapeutic;therapeutic target;Tissues;Transfection;Transportation;TRPV1 gene;uptake;voltage clamp

PROJECT_TITLE: Pharmacologically tuning membrane permeability to drug-sized organic cations through activation of KCa3.1 channels


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Heart disease is responsible for over 600,000 deaths annually, making it the number one killer of women and men in the United States. There are currently no small diameter vascular grafts that effectively treat this disease. This proposal seeks to use computational tools to fabricate a fully biodegradable small diameter vascular tissue engineered graft that is and remains compliance matched as it remodels in-vivo.

PI_NAMEs: VANDE GEEST, JONATHAN PIETER (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acute;Adult;Animal Model;Animals;Anti-Inflammatory Agents;Aorta;Autologous;Bilateral;Biopolymers;Blood Vessels;Bypass;calponin;Cd68;Cells;Cessation of life;Characteristics;Clinical;Clinical Treatment;Collagen;Computer Simulation;computerized tools;controlled release;Coronary Artery Bypass;Coronary heart disease;cost efficient;Deposition;design;Development;Diameter;Disease;Elements;Endothelium;Environment;Exhibits;Extracellular Matrix;Failure;Gelatin;graft failure;Heart Diseases;hemodynamics;Hyperplasia;Implant;implantation;improved;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Legal patent;Macrophage;Maintenance;mechanical properties;Mechanics;men;Modeling;Myosin Heavy Chains;novel;Organ Transplantation;Performance;Phenotype;Play;pre-clinical;pre-clinical assessment;preimplantation;Process;Production;Rattus;recruit;Reporting;Research;Research Project Grants;response;Role;Saphenous Vein;Sheep;Site;Smooth Muscle Myocytes;Sprague-Dawley Rats;Testing;thrombogenesis;Thrombosis;Tissue Engineering;Transforming Growth Factor Beta 2;translational potential;Tropoelastin;United States;Vascular Diseases;Vascular Graft;Vascular Smooth Muscle;vascular tissue engineering;Woman;Work

PROJECT_TITLE: Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Diabetes

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This proposal will provide recent college graduates from under-represented minority groups with an intensive two-year mentored research experience in a laboratory that studies diabetes, endocrinology, and metabolism, and tailored professional development coursework to successfully guide them through the graduate school application process and ensure their success in completing a research-focused biomedical degree program (PhD or MD/PhD). Through our proposed recruitment efforts and multi-layered mentoring approach, this proposal will build and enhance the diversity of the biomedical research workforce in NIDDK mission areas.

PI_NAMEs: ARBELAEZ, ANA MARIA ;BROOKHEART, RITA THOMAS;REEDS, DOMINIC N (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Area;Award;Biomedical Research;career;cohort;Collaborations;college;Communities;Competence;Complex;cultural competence;Data;data integration;Data Pooling;Data Scientist;Decision Making;Degree program;design;Development;Development Plans;Diabetes Mellitus;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational workshop;effectiveness evaluation;Endocrinology;Enrollment;Ensure;Environment;Equity;Evaluation;evidence base;experience;Faculty;Fostering;Goals;graduate school;improved;Individual;Infrastructure;Institution;interest;Laboratory Study;Lead;Life Experience;meetings;member;Mentors;Mentorship;Metabolic Diseases;Metabolism;Methods;Minority Groups;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome Assessment;Pathway interactions;peer networks;Population;Postbaccalaureate;Process;Program Evaluation;programs;recruit;Reduce health disparities;Reproducibility;Research;Research Personnel;Research Support;Research Training;Resources;response;Science;Site;skills;Social Network;Structure;Students;success;support network;Techniques;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Washington

PROJECT_TITLE: Postbaccalaureate Research Education Program In Diabetes, Endocrinology and Metabolic Diseases (PRIDE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (M1)]