ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed Tennessee State University (TSU) Undergraduate Research Training Initiative for Student Enhancement (U-RISE) program would increase the pool of historically under-represented (UR) research scientists. This will be achieved by offering enhanced curricula, rigorous undergraduate research experiences, and psychosocial resources to maximize the preparedness of UR students to enter and complete Ph.D. programs in biomedical research. The diversity of the students that emerge from the program will provide a more nuanced and sensitive approach to the host of public health challenges that occur among the increasingly diverse population.

PI_NAMEs: WHALEN, MARGARET M (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Admission activity;African American;Biology;Biomedical Research;career;Chemistry;Community of Practice;Critical Thinking;Discipline;Doctor of Medicine;Doctor of Philosophy;Educational workshop;experience;Goals;graduate school;graduate student;Graduation Rates;Hispanic;Historically Black Colleges and Universities;learning community;Measures;meetings;Paper;Participant;programs;Psychology;psychosocial resources;Research;Research Training;retention rate;Schools;Science;skills;Students;Tennessee;Training and Education;undergraduate research;undergraduate student;Underrepresented Students;Universities;verbal;Work

PROJECT_TITLE: U-RISE at Tennessee State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative These interdisciplinary studies are relevant to public health for two reasons. First, they may reveal the novel RNA biomarkers linked to (and possibly causal of) early development of Parkinson's disease. Secondly, the 3D organoid (“mini- brain-on-chip”) and its secreted vesicles developed here will provide a meaningful, highly innovative, close-to-brain platform for RNA therapeutics development.

PI_NAMEs: DONG, XIANJUN ;LEE, LUKE P. (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Area;Autopsy;Bioinformatics;Biological Markers;Biology;Biomedical Engineering;Biopsy;blood-brain barrier penetration;Brain;brain control;Brain Diseases;Cells;Chromosome Pairing;circular RNA;Clinical;Collection;Complex;Coupling;data modeling;Data Set;design;Detection;Development;Diagnostic;differential expression;Disease;Dopamine Receptor;dopaminergic neuron;Dyskinetic syndrome;effective therapy;Electrodes;Electroencephalography;Electrophysiology (science);Enhancers;Environment;exosome;extracellular vesicles;first-in-human;Foundations;Functional disorder;Gene Cluster;Genes;Genetic;Genomics;Half-Life;Human;in vitro Model;innovation;Interdisciplinary Study;Link;Liquid substance;Maps;Measures;Messenger RNA;Methods;MicroRNAs;Midbrain structure;Modeling;Molecular;Monitor;Movement Disorders;multi-electrode arrays;multidimensional data;Nanostructures;Nature;Nerve Degeneration;Nervous System Disorder;neural network;neuroimaging;Neurology;neuron loss;Neuronal Dysfunction;neuropathology;neurophysiology;Neurosciences;Noise;novel;Organogenesis;Organoids;Parkinson Disease;Pathogenesis;Pathology;patient derived induced pluripotent stem cells;Pattern;Perfusion;Pharmacologic Substance;Physiological;Protocols documentation;Proxy;Public Health;risk variant;RNA;Role;Series;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;Synapses;System;Testing;Therapeutic;therapeutic development;therapeutic RNA;three dimensional cell culture;Time;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translations;treatment response;Untranslated RNA;Vesicle

PROJECT_TITLE: Systematic Study of Extracellular Vesicles and their Integrative Analysis with Parkinson's Organoids MAP

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE  PROJECT NARRATIVE  Teenagers who use marijuana and go to juvenile court are more likely to face arrest or addiction in the future. Treating their marijuana use within the court system is ideal, but treatments would need to be inexpensive and easy to deliver. This study will test a new smartphone app to help teenagers in the court system cut down on their marijuana use.

PI_NAMEs: HELSETH, SARAH ASHLEY (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adolescent;Adolescent marijuana use;adolescent substance use;Adult;Age;Alcohols;Area;barrier to care;behavior change;Behavior Therapy;Behavioral;behavioral health;Bypass;career;career development;Cellular Phone;Clinical;Collaborations;Community Healthcare;community setting;computerized;cost;court;Data;design;Development;Development Plans;digital;Drug Screening;Early Intervention;early onset;efficacy research;empowerment;Enrollment;evidence base;Evidence based practice;Face;Family;Future;Goals;Health;health application;health equality;high risk;high risk behavior;Hour;Imprisonment;improved outcome;Intervention;Intervention Studies;Interview;Justice;juvenile justice system;Knowledge;Link;Manuals;Maps;Marijuana;marijuana use;Measures;Mediator;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;mobile application;Modeling;Modernization;Motivation;motivational enhancement therapy;motivational intervention;multidisciplinary;National Institute of Drug Abuse;natives;Notification;novel;Outcome;Parents;peer;peer influence;peer networks;Persons;Phase;Population;preference;primary outcome;Procedures;Productivity;prototype;Public Health;public health relevance;Publishing;Qualitative Methods;Randomized, Controlled Trials;rearrest;reduce marijuana use;reduced substance use;Research;Research Activity;Research Personnel;Resources;Rhode Island;Risk;secondary outcome;Series;skills;smartphone application;Structure;substance use;Substance Use Disorder;substance use treatment;System;Technology;technology development;Teenagers;Testing;theories;therapy development;Time;tool;Training;Training Activity;Training Support;treatment as usual;university student;Withdrawal;Work;Youth

PROJECT_TITLE: Development and Preliminary Testing of an Adjunct Smartphone App to Reduce Marijuana Use in Court-Involved, Non-Incarcerated Adolescents

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The kidney is a complex organ whose essential roles include filtering waste from the blood, regulating blood pressure, and maintaining electrolyte balance. This project will develop a microscopy-based technique to study the organization of the genome of kidney cells and it will use the new technique to study aging in model mouse kidney tissue. The tools and findings of this project will enable researchers to study genome organization in kidney or other tissues and will illuminate the molecular details of aging.

PI_NAMEs: VAUGHAN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Adult;Aging;aging related;American;base;Blood;blood pressure regulation;Cells;Cessation of life;Chromatin;Chronic Kidney Failure;Complex;Correlative Study;Cultured Cells;design;Dialysis procedure;Disease;Dissociation;DNA;DNA Methylation;Electrolyte Balance;End stage renal failure;Endothelial Cells;Epigenetic Process;epigenetic profiling;Evaluation;Face;field study;Fluorescent in Situ Hybridization;Generations;Genome;genome-wide;genomic locus;glomerular basement membrane;Goals;Health Expenditures;healthy aging;Heterochromatin;histone modification;Histones;human old age (65+);Image;In Situ;Individual;Injury;innovation;insight;Kidney;kidney cell;Kidney Diseases;kidney imaging;Maps;Measures;Methods;microscopic imaging;Microscopy;Molecular;Molecular Conformation;molecular phenotype;mouse model;Mus;nanoscale;novel;Organ;Phenotype;Physiological;Physiology;podocyte;Population;Post-Translational Protein Processing;Publishing;Renal function;Research Personnel;Risk;Role;senescence;single cell analysis;Specimen;Stains;superresolution microscopy;Techniques;Technology;Time;Tissues;tool;Transplantation;ultra high resolution;Use of New Techniques;wasting;whole genome;Work

PROJECT_TITLE: in situ Epigenetic Profiling of Single Cells in Kidney


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Autism spectrum disorder (ASD) is a difﬁcult and growing problem. The goal of this project is to develop sensitive and quantitative image analysis methodology for the study of ASD aimed at measuring brain pathology and using it to characterize and predict response to therapy. This work will advance our understanding of this disorder and its treatment and ultimately inform and guide personalized therapies.

PI_NAMEs: DUNCAN, JAMES S (contact);STAIB, LAWRENCE H.;SUKHODOLSKY, DENIS G;VENTOLA, PAMELA

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: Accounting;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;base;Behavior Therapy;Biological Markers;biomarker identification;Brain;Brain Diseases;Brain imaging;Brain Pathology;Brain region;Categories;Characteristics;Child;Child Behavior Checklist;childhood anxiety;Classification;Clinical;Clinical assessments;Cognitive Therapy;cohort;Communities;comorbidity;convolutional neural network;cost;Data;data exchange;Data Set;Databases;deep learning;Dependence;design;Development;developmental disease;Disabling;Disease;evidence base;federated learning;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Genetic;Goals;Graph;graph neural network;Heterogeneity;Image Analysis;Impairment;improved;improved outcome;Individual;innovation;Institution;Judgment;large datasets;Learning;learning network;learning strategy;Literature;long short term memory;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Mental Depression;Methodological Studies;Methodology;Methods;Modeling;Molecular Biology;neuroimaging marker;Neurosciences;novel;novel strategies;Outcome Measure;outcome prediction;Oxytocin;Patients;Performance;personalized biomarkers;personalized medicine;personalized predictions;Pharmacotherapy;Phenotype;Poly(ADP-ribose) Polymerases;Prediction of Response to Therapy;Prevalence;Privacy;privacy preservation;psychiatric comorbidity;psychoeducation;quantitative imaging;recurrent neural network;repetitive behavior;Rest;Secure;Services;Severities;Signal Transduction;social;social communication;Social Interaction;spatial relationship;spatiotemporal;Subcategory;Subgroup;Supportive care;task analysis;Techniques;Technology;Testing;therapy outcome;Time;tool;Training;Treatment outcome;treatment response;treatment strategy;United States;Universities;Virginia;Work

PROJECT_TITLE: Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The mission of the University of Iowa Institute for Clinical and Translational Science (ICTS) is to accelerate the translation of scientific discovery into practical health care through programs that develop the translational science workforce, promote the engagement of community members, allied health providers and diverse populations that suffer from health disparities, and to catalyze innovations that enable transformations in the infrastructure and processes that support translational science. These efforts will lead to the development of novel therapies and healthcare delivery strategies, the integration of translational research into clinical practices, and, ultimately, to measurable improvements in the health of Iowa and the nation.

PI_NAMEs: HANSEN, MARLAN R;WINOKUR, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: CHANG, SOJU

PROJECT_TERMS: Acceleration;Adoption;Affect;Age;Ally;Automobile Driving;Basic Science;Biomedical Research;care systems;Caring;catalyst;Clinic;Clinical;clinical care;clinical implementation;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community engagement;community organizations;Community Practice;community setting;Computerized Medical Record;Data;Data Collection;data infrastructure;data platform;data warehouse;demographics;design;Development;Disease Outcome;Diverse Workforce;Education;efficacy testing;Environment;evidence base;Family Physicians;Funding;Genetic;geographic barrier;Geography;Goals;Health;health care availability;health care delivery;health disparity;Health Personnel;Health system;Healthcare;Healthcare Systems;Home;Human;Human Subject Research;implementation science;improved;Individual;Informatics;informatics infrastructure;Infrastructure;innovation;Institution;Integrated Health Care Systems;interoperability;Intervention;Iowa;Learning;Life;life span;Link;Measurable;Medical Care Team;medical specialties;member;Mentors;Methods;Mission;mobile computing;Modeling;multidisciplinary;new technology;novel;novel strategies;novel therapeutics;Outcome;Patient Participation;Patients;Pharmacists;Physicians;Play;Population;population health;Population Heterogeneity;practice-based research network;precision medicine;Process;programs;Provider;Research;Research Methodology;Research Personnel;Role;Rural;rural area;Rural Community;rural disparities;rural dwellers;Rural Population;rurality;School Nursing;Science;Scientist;Side;social;stakeholder perspectives;System;systems research;Technology;Testing;Time;tool;Training;Translational Research;translational scientist;Translations;underserved community;Universities;virtual;Work;workforce needs


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction. Data from this project will inform a new model of BN symptoms and identify more precise, state-specific intervention targets for this costly and often chronic disorder.

PI_NAMEs: BERNER, LAURA A. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Adult;Behavior;Behavioral;behavioral economics;Behavioral Research;behavioral response;Binge Eating;Brain;Bulimia;Cessation of life;Characteristics;Choice Behavior;Chronic;Chronic Disease;Clinical;clinically significant;Cognitive;cognitive control;cognitive neuroscience;computational neuroscience;Computer Models;Corpus striatum structure;cost;Cost Control;Data;Decision Making;dietary restriction;Diffusion;disability;Disabling;discount;discounting;Disease;Dorsal;Eating;Eating Disorders;Ecological momentary assessment;Elements;expectation;experience;Failure;Fasting;follow-up;food consumption;Functional Magnetic Resonance Imaging;Goals;Hyperphagia;ideal observer (Bayesian);Impairment;Impulsivity;Individual;innovation;Intake;Intervention;Laboratories;Lateral;Learning;Matched Group;Measures;medical complication;Metabolic;Modeling;multimodality;Nature;neural;Neurocognitive;neuroimaging;neuroregulation;novel;Outcome;Patient Self-Report;Patients;Prefrontal Cortex;premature;Probability;Process;process improvement;Prognostic Marker;Psychiatry;Psychotic Disorders;purge;Research;Resistance;response;Role;Sampling;Satiation;Scanning;Severities;Signal Transduction;smartphone based assessment;Standardization;Statistical Methods;substance use;Symptoms;Testing;Time;Training;trait;Update;Ventral Striatum;Woman;Work

PROJECT_TITLE: Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Microbiome;Nutrition;Osteoporosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: 8. PROJECT NARRATIVE The long term goal of this work is to prevent age- and osteoporosis-related fractures. In this project we study how the microbiome (bacteria living in the body) influence bone strength. The work has the potential to lead to new treatments to prevent osteoporosis-related fractures.

PI_NAMEs: HERNANDEZ, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Age;aged;Animals;Antibiotics;Bacteria;Binding;Biochemical;Biomechanics;bone;Bone Density;bone fragility;bone loss;bone mass;Bone Matrix;bone quality;bone strength;Bone Tissue;Chemicals;density;Dependence;Development;Diagnostic;Disease;Estrogens;experimental study;fracture risk;Genes;Genetic;Geometry;Germ-Free;Gnotobiotic;Goals;Growth;gut microbiome;gut microbiota;Human;Impairment;improved;Individual;Knock-out;life span;Link;mature animal;Measures;Mechanics;Metagenomics;Microbe;microbial;microbial community;Microbial Genetics;Microbial Taxonomy;microbiome;microbiome research;microbiome therapeutics;microbiota;Minerals;Modification;Mus;nanoscale;novel;Organ;Organism;Orthologous Gene;Osteocalcin;Osteoporosis prevention;osteoporosis with pathological fracture;Pathway interactions;Performance;Phenotype;Phylogeny;preclinical study;pregnane X receptor;prevent;Process;Production;Proteins;Regulation;Reporting;Role;side effect;skeletal;Skeleton;SXR receptor;targeted treatment;Taxonomy;Testing;Time;Tissues;Vitamin K;Work

PROJECT_TITLE: The Microbiome and Bone Strength

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Contraception/Reproduction;Genetics;Heart Disease;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Long QT syndrome (LQTS) raises the risk of stillbirth and miscarriage, but the mechanisms underlying these effects are unknown. This project may elucidate these mechanisms and accelerate the development of interventions to prevent the adverse outcomes observed in LTQS pregnancies.

PI_NAMEs: CUNEO, BETTINA FRANCESCA;LORCA, RAMON A (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;Acceleration;adverse outcome;adverse pregnancy outcome;Arrhythmia;Arteries;Biometry;Birth Weight;Blood flow;Blood Vessels;Cardiac;Cesarean section;chorionic plate;Clinical;comparison control;Data;diagnostic strategy;Erythrocytes;Etiology;experience;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;fetal loss;Fetal Reduction;Fetus;Gene Expression;General Population;Genes;Genotype;Gestational Age;Heart;Heart Arrest;High Prevalence;high risk;Human;Immunohistochemistry;Impairment;improved;In Vitro;indexing;Individual;Inherited;Investigation;Length;Life;Live Birth;Long QT Syndrome;Measurement;Mothers;mutant;Mutation;Myography;Myometrial;myometrium;Neonatal;new therapeutic target;offspring;Outcome Study;Pathogenicity;Patients;Perfusion;pharmacologic;Placenta;Placental Insufficiency;post pregnancy;Potassium Channel;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;pregnant;prevent;protein expression;Research;Resistance;response;Risk;Role;Romano-Ward Syndrome;Sampling;Spontaneous abortion;stillbirth;Testing;therapy development;Tissues;tool;ultrasound;Uterus;Variant;vascular bed;Vascularization;Vasodilation;Ventricular Arrhythmia;voltage;Voltage-Gated Potassium Channel;Western Blotting;Woman;Work

PROJECT_TITLE: Potassium channels and uteroplacental vessels function in pregnant long QT type 1 women

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Mild traumatic brain injury, or concussion, gives rise to cognitive deficits, chiefly inattention, that overlap the phenotype of comorbid attention-deficit hyperactivity disorder (ADHD) during adolescence. The proposed research capitalizes on this clinical window of opportunity to compare fMRI-based neural signatures of acquired vs primary inattention. This study will leverage innovative analytic approaches and already-collected data from the Adolescent Brain Cognitive Development (ABCD) study, the largest ever fMRI study of 11,875 children, to advance scientific understanding of cognitive deficits following traumatic brain injury as compared to primary attention deficit in ADHD.

PI_NAMEs: KAY, BENJAMIN PAUL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Attention;Attention deficit hyperactivity disorder;Attentional deficit;Back;Biometry;Brain;Brain Concussion;Brain Injuries;Brain region;career;Child;Childhood;Childhood Injury;Clinical;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive development;cognitive neuroscience;cognitive testing;cohort;comorbidity;comparison control;Controlled Study;Craniocerebral Trauma;Data;design;Diagnosis;Diagnostic;experimental study;Functional Magnetic Resonance Imaging;Funding;Future;Gender;Goals;Hospitals;Image;imaging study;inattention;innovation;Linear Models;Linear Regressions;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Medicine;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mild traumatic brain injury;Modeling;MRI Scans;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neuroimaging;Neurologic;Neurologic Deficit;neuromechanism;neuronal patterning;Observational Study;Outcome;Participant;Pattern;Performance;Pharmaceutical Preparations;Phenotype;Physicians;Population;power analysis;prescription stimulants;programs;Recording of previous events;recruit;Reporting;Research;Rest;Scanning;Schools;Scientific Advances and Accomplishments;Scientist;Severities;Short-Term Memory;Signal Transduction;Socioeconomic Status;statistics;Stimulant;stimulant use;sustained attention;Symptoms;Techniques;Testing;Time;Training;Traumatic Brain Injury;treatment response;United States National Institutes of Health

PROJECT_TITLE: Concussion and Attention-Deficit/Hyperactivity Disorder: Investigating the relationship between cognitive outcome, prescription stimulants, and functional MRI biomarkers in the ABCD study.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE Diabetes distress—stress, fear, and guilt related to managing diabetes—is linked to poor glycemic control and disproportionately affects vulnerable populations. Screening for and intervening on high levels of diabetes distress is now a part of diabetes care guidelines, but no studies have tested diabetes distress screening and treatment interventions in a real-world primary care setting. This pragmatic study will compare a program to support community health center (CHC) healthcare teams deliver systematic diabetes distress screening and intervention (6 CHCs) to enhanced usual care (6 CHCs) and assess its impact on glycemic control (A1C) among adults with type 2 diabetes.

PI_NAMEs: BAIG, ARSHIYA AHMED (contact);HESSLER, DANIELLE MARIE

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;Affect;African American population;Algorithms;American;Anxiety;arm;Behavior;behavioral health;Blood Glucose;Blood Pressure;Body mass index;Caring;Charge;Clinic;Clinical;clinical care;Complex;Country;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;diet and exercise;dietary;Disparity;Disparity population;Distress;effectiveness/implementation design;Emotional;ethnic minority;evidence base;evidence based guidelines;Exercise;Family;federal poverty level;Financial Hardship;follow-up;Fright;glycemic control;Glycosylated Hemoglobin;Guidelines;Guilt;Habits;Health;health disparity;Health Personnel;health training;Hispanic;Hispanic Populations;Hypoglycemia;implementation evaluation;implementation outcomes;improved;Income;instrument;International;Intervention;Intervention Studies;Interview;Knowledge;lectures;Life;Link;Low-Density Lipoproteins;Maintenance;Medical Care Team;medical vulnerability;medication compliance;Mental Depression;Meta-Analysis;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;patient oriented;patient screening;Patients;people of color;Persons;Pharmaceutical Preparations;Population;pragmatic randomized trial;pragmatic study;Prevalence;Primary Care;primary care setting;primary outcome;Process;profession allied to medicine;programs;Publishing;Quality of life;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;relative effectiveness;Reporting;Risk;Rural;screening;secondary outcome;Services;social;Source;Standardization;Stress;Structure;Surveys;Testing;Training;transportation access;treatment as usual;Visit;Vulnerable Populations;Work

PROJECT_TITLE: ARISE (Achieving Routine Intervention and Screening for Emotional health)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative mRNA-LNPs are the backbone of the highly successful COVID-19 vaccines. We propose to develop mRNA-LNPs that will deliver HIV-specific CARs to tissues and cells that are enriched for cells harboring the latent reservoir. Our underlying hypothesis is that by expressing HIV CARs in areas where HIV hides from CTLs, “kick and kill” strategies will be much more effective in reducing the reservoir.

PI_NAMEs: PARHIZ, HAMIDEH ;RILEY, JAMES L. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Antibodies;antiretroviral therapy;Area;B-Lymphocytes;CD4 Positive T Lymphocytes;cell type;Cells;Clinic;Complex;COVID-19 vaccine;CXCR4 gene;design;Development;Effectiveness;Encapsulated;Environment;Exclusion;experimental study;FDA approved;Genetic;Gills;Goals;Half-Life;HIV;HIV Infections;humanized mouse;Immune;immune clearance;Immune system;Immunotherapy;In Vitro;in vivo;Individual;Injectable;Lead;Length;lipid nanoparticle;lymph nodes;Macrophage;manufacture;Messenger RNA;Modeling;monocyte;nonhuman primate;Nucleosides;Persons;Phase I Clinical Trials;Pilot Projects;Proteins;reproductive tract;Research Personnel;Resistance;RNA;Site;success;T-Lymphocyte;targeted delivery;Technology;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;trafficking;vaccine delivery;Vertebral column;Viral reservoir;Viremia;Virus

PROJECT_TITLE: Eliminating the latent reservoir by targeted in vivo delivery of HIV-specific CARs


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Regulation of ERK activity through dephosphorylation by phosphatases is critical for female fertility; alterations to ERK activity results in female infertility. For decades the DUSP6/7 homolog LIP-1 in worms was thought to function as an ERK phosphatase in the female germline in worms; recent work shows that LIP-1 and its ortholog DUSP6/7 do not regulate ERK activity during oogenesis in worms and mice. The goal of this proposal is to identify the phosphatase that controls ERK, in vivo, during oogenesis and generate reagents to study its function in depth.

PI_NAMEs: ARUR, SWATHI  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Active Sites;Acute;Alleles;antibody detection;Biological Assay;Caenorhabditis elegans;Cell Physiology;Chromosomes;complex biological systems;CRISPR/Cas technology;Development;Diplotene Stage;DUSP6 protein;Equilibrium;Evaluation;Event;Evolution;extracellular;Extracellular Signal Regulated Kinases;Female;female fertility;Female infertility;follow-up;gain of function;Generations;Genes;Germ Cells;Germ Lines;Goals;Homologous Gene;Human;Immunofluorescence Immunologic;In Vitro;in vivo;Knock-in;Knowledge;Lateral;loss of function;Mammals;MAP3K1 gene;Maps;Mediating;Meiosis;MEKs;Mitogen-Activated Protein Kinase Kinases;Molecular;Mus;mutant;Mutate;Oocytes;Oogenesis;Orthologous Gene;Pachytene Stage;Pathway interactions;Pattern;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Protein Dephosphorylation;Protein Kinase;Protein Kinase C;Proteome;Reagent;Regulation;Reproductive Health;Reproductive Medicine;RNA Interference;RNA interference screen;Role;Signal Induction;Signal Transduction;spatiotemporal;Specificity;Sterility;subfertility;System;Testing;Threonine;Time;Tyrosine;Visualization;Work

PROJECT_TITLE: Spatio-temporal regulation of ERK signaling by phosphatases in the female germline


PHR: OVERALL: PROJECT NARRATIVE Release of radionuclides after an industrial or medical radiological accident or detonation of a nuclear device may result in significant radionuclide exposure of general population. This program entwines projects that develop tools and approaches to evaluate, model and mitigate such exposures and their health threat.

PI_NAMEs: WOLOSCHAK, GAYLE E. (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Address;Age;Animal Model;Architecture;Biological;Biological Markers;Biological Models;Cells;Chemicals;Chemistry;Communities;data modeling;Daughter;Development;Devices;DNA;dosimetry;Educational process of instructing;Evaluation;Excision;Exposure to;External Beam Radiation Therapy;Fluorescence Microscopy;General Population;genetic makeup;Goals;Half-Life;Health;Histology;human model;Immune system;Immunohistochemistry;improved;in silico;Industrialization;Information Distribution;Intake;internal radiation;Knowledge;Literature;Measurement;Medical;Metabolism;migration;model development;Modeling;molecular marker;Morphology;novel;Nuclear;Nuclear Accidents;Organ;particle;Particle Size;phantom model;pharmacokinetics and pharmacodynamics;Physiology;Process;programs;Radiation;Radiation Accidents;Radiation Physics;Radiobiology;Radiochemistry;Radioisotopes;Reaction;Recording of previous events;Research;Roentgen Rays;Route;Science;sex;Signal Transduction;Solubility;Specificity;Structure;Technology;tissue repair;Tissues;tool;Toxic effect;uptake;virtual

PROJECT_TITLE: Multi-Scale Evaluation and Mitigation of Toxicities Following Internal Radionuclide Contamination


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Emergency Care

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The program proposed here aims to strengthen the international research ethics training capacity in Kenya while also addressing the specific needs related to One Health research and emergency health research. As a collaboration between the University of Nairobi (UoN) and The Ohio State University (OSU), it will offer in-depth training and experiences in research ethics and integrity through establishing and running both a 1-year postgraduate diploma (PGD) and a 2-year MSc in One Health and Emergency Research Ethics (MOHERE) at UoN. It will also fund and mentor 6 future leaders in bioethics and research ethics to take the OSU MA in Bioethics so that together all these graduates will become leaders in a sustainable, rigorous and exciting culture of research ethics in Kenya.

PI_NAMEs: O'MATHUNA, DONAL  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Achievement;Address;Advisory Committees;Agriculture;Animals;Area;Bioethics;Bioethics Consultants;Collaborations;Committee Members;Competence;Complex;Consultations;Country;COVID-19;Development;Disasters;Disease Outbreaks;Education;Educational Activities;Educational process of instructing;Educational workshop;Emergency research;Emergency Situation;Ensure;Environment;Environmental Health;Ethical Issues;Ethics;experience;Feedback;Fostering;Funding;Future;global health;Goals;Government;Growth;Guidelines;Health;Health Professional;Human;human subject;improved;Institution;Institutional Ethics;interdisciplinary approach;International;Investments;Kenya;Knowledge;Leadership;Link;low and middle-income countries;Mentors;microbial;Monitor;multidisciplinary;next generation;Ohio;pandemic disease;Participant;Persons;Plants;Play;Policies;Post Graduate Year;Prevention;Process;programs;Protocols documentation;Regulation;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;response;Review Committee;Running;Scholarship;Scientist;skills;social;Surveys;System;Time;Training;Training and Education;Travel;Universities;Virus Diseases;webinar;Work

PROJECT_TITLE: UoN-OSU MSc in One Health and Emergency Research Ethics (MOHERE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Lung;Lymphatic Research;Pediatric

PHR: NARRATIVE The process of maintaining blood vessel integrity is highly coordinated involving many molecular players that act in concert. We will investigate how one protein, PTPN14, helps orchestrate these processes. Our study has biomedical significance to blood vessel pathologies and to regenerative medicine to learn how to generate stable blood vessels.

PI_NAMEs: AKHURST, ROSEMARY J (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Acute Lung Injury;ACVRL1 gene;Adult;Affect;Alleles;Amino Acids;angiogenesis;antagonist;Architecture;Arteriovenous malformation;assault;Binding;Biological Assay;Blood flow;Blood Vessels;Brain;Breeding;cadherin 5;cell type;Cells;Cellular biology;Chemicals;Co-Immunoprecipitations;Collagen;Complex;Corneal Injury;COVID-19;Cytoprotection;Development;Disease;drug repurposing;Edema;Endoglin;Endothelial Cells;Endothelium;Equilibrium;Extracellular Matrix;Eye diseases;Fibrocartilages;gene interaction;Genes;Genetic;Genetic study;genetic variant;Genetic Variation;Growth;Growth Factor;Hemorrhage;Hereditary hemorrhagic telangiectasia;Homeostasis;Human;human disease;Human Engineering;Human Genetics;Hypoxia;imager;Immune;In Vitro;in vivo;Incidence;Inflammation;insight;Intercellular Junctions;knock-down;Knock-out;Knowledge;Learning;Life;Liver;loss of function mutation;Lung;lymphatic development;Lymphatic Endothelium;lymphatic malformations;lymphatic vessel;Lymphedema;MADH4 gene;Maintenance;malformation;Malignant Neoplasms;Mechanical Stress;mechanotransduction;Mediating;microCT;migration;Molecular;Molecular Biology;molecular marker;Mus;Mutation;new therapeutic target;notch protein;Nuclear;Nutrient;Organ;Oxygen;Pathologic;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Peripheral arterial disease;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;prevent;Process;Proliferating;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proteins;pulmonary arteriovenous malformation;Pulmonary Hypertension;quantum;rare mendelian disorder;receptor;Recovery;Regenerative Medicine;Regulation;Reporter;Reporting;response;Retina;retinal angiogenesis;Role;S10 grant;segregation;shear stress;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Skin;Syndrome;Tamoxifen;Telangiectasis;Tissues;Transforming Growth Factor beta;Variant;vascular abnormality;vascular bed;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular Permeabilities;Vascular remodeling;Vascular System;wound

PROJECT_TITLE: Protein tyrosine phosphatase non-receptor 14 in vascular stability and remodeling

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: 8. PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH This project will contribute to our understanding of the molecular mechanisms that cause accelerated aging, decreased health, and shorter lifespan in offspring from older mothers. This study is innovative and significant in its use of an emerging model system in aging research to examine the role of mitochondrial dysfunction in maternal age effects on offspring aging. Our work has the potential to identify a cause of interindividual variability in lifespan and to identify targets for therapies to improve health and increase lifespan.

PI_NAMEs: GRIBBLE, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;advanced maternal age;Affect;Age;age acceleration;age effect;age related;age related changes;aged;Aging;Animals;Area;Autophagocytosis;Behavior;Biochemical;Biogenesis;Biological Models;Caring;cell injury;Cells;Communication;comparative;Complex;Development;Disease;early onset;Embryo;Embryonic Development;Etiology;experimental study;extend lifespan;Female;female fertility;Fertility;fitness;Functional disorder;Gene Expression;Genes;Health;healthspan;Homeostasis;Homologous Gene;Human;Image;imaging approach;improved;Incidence;Inherited;innovation;inter-individual variation;intergenerational;Invertebrates;Investments;life span;Life Tables;Literature;male;Maternal Age;Measures;Metabolic;Metabolism;Microscopic;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Mothers;Motility;Nerve Degeneration;Nuclear;offspring;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;pharmacologic;Pharmacologic Substance;Phenotype;Population;postnatal;Production;Public Health;Reactive Oxygen Species;Reproduction;reproductive;Research;Resistance;response;RNA Interference;Role;Signal Transduction;Source;Spirometry;Stress;Structure;System;targeted treatment;Testing;Time;transcriptome sequencing;Work;young mother

PROJECT_TITLE: Mitochondrial mechanisms of maternal age effects on offspring health and lifespan

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Glioblastoma multiforme (GBMs) is one of the most malignant tumors of the central nervous system (CNS) in humans and has an extremely poor prognosis. We are the first to report that the suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human gliomas, indicating that TRPM7 may represent a novel and promising target for the therapeutic intervention of malignant glioma. The proposed study will delineate the molecular mechanisms of TRPM7 in the development and progression of glioma tumorigenesis and stemness, as well as develop TRPM7 as a novel drug target for glioma patients.

PI_NAMEs: LIU, MINGLI  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Aggressive behavior;aldehyde dehydrogenase 1;Apoptosis;Biologic Characteristic;Biological;Cations;Cell Proliferation;Cells;Central Nervous System Neoplasms;chemoradiation;Data;Development;Down-Regulation;Drug Targeting;Failure;Gene Silencing;Genes;Glioblastoma;Glioma;glioma cell line;Heterogeneity;Homeostasis;Human;Hypoxia;improved;in vivo;Infiltration;Invaded;Ligands;Maintenance;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of central nervous system;Mediating;MGMT gene;migration;Modeling;Molecular;molecular subtypes;Mus;nanoparticle;new therapeutic target;notch protein;Notch Signaling Pathway;novel;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Permeability;Phosphotransferases;Physiological;Prognosis;prognostic;Proliferating;Property;Protein-Serine-Threonine Kinases;Radiation therapy;RAS Superfamily Proteins;receptor;Recurrent tumor;Regulation;Reporting;Resistance;response;Role;self-renewal;Serine;Signal Transduction;Small Interfering RNA;standard of care;STAT3 gene;stem;stem cell biomarkers;stem cell growth;stem cells;stemness;System;targeted treatment;temozolomide;Testing;Therapeutic Intervention;Tissues;Trace metal;Treatment Failure;tumor;tumor growth;tumor xenograft;tumorigenesis;Tumorigenicity;Variant;Vertebrates;Xenograft Model

PROJECT_TITLE: TRPM7 induces tumorigenesis and stemness through Notch activation in glioma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Physical Injury - Accidents and Adverse Effects

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Aging and injury are among the major global health problems and death due to injury increases sharply with age. Hemorrhage accounts for almost half of trauma-related deaths. In this proposal we seek to identify endogenous juvenile factors that can reduce the adverse influence of aging on outcome following hemorrhagic shock.

PI_NAMEs: RAJU, RAGHAVAN PILLAI (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Adverse effects;Age;age effect;age group;age related;age related changes;age related neurodegeneration;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;animal old age;Antioxidants;Autophagocytosis;biochemical tools;Biological;Biological Models;Biology of Aging;Cells;Cessation of life;cognitive function;comorbidity;Data;Deterioration;Development;disability;disease model;effective therapy;Elderly;Equilibrium;Exhibits;exosome;Experimental Models;experimental study;extracellular vesicles;functional decline;Functional disorder;Gene Expression;Genes;genomic tools;global health;Goals;Heart;Hemorrhage;Hemorrhagic Shock;high risk;human disease;human old age (65+);Hypoxia;Impaired cognition;improved;improved outcome;Injury;Intestines;juvenile animal;Knowledge;life span;Liver;Lung;mature animal;Methods;MicroRNAs;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neurodegenerative Disorders;old mice;older patient;Organ;Outcome;Outcomes Research;Oxidative Stress;Pathology;Pathway interactions;Patients;Plasma;protective effect;protective factors;Published Comment;Rattus;Research;resilience;response;Role;Sex Differences;Sexual Maturation;SIRT1 gene;System;Techniques;Testing;Therapeutic;Time;Trauma;Traumatic injury;United States National Institutes of Health

PROJECT_TITLE: Reparative effect of juvenile factors in aging and injury

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Pain typically is measured by patient self-report, but self-reported pain is difficult to interpret and may be impaired or not possible to obtain. We will use clinically well-characterized data to: (1) develop an automatic multimodal method for the detection of occurrence and intensity of pain in five of the most common and disabling acute and chronic LBP conditions; (2) use EMA to characterize early point psychosocial and behavioral signs that acute pain is likely to become chronic.

PI_NAMEs: HAMMAL, ZAKIA  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Acute;Acute Pain;Aftercare;American;analog;anxious;Articular Range of Motion;Behavioral;Biological Assay;Brief Pain Inventory;Cellular Phone;Characteristics;Chronic;Chronic low back pain;chronic pain;Clinic;Clinic Visits;Clinical;Clinical assessments;Clinical Data;clinical practice;comorbidity;Computer Assisted;Computer Vision Systems;Consent;contextual factors;cost effective;Data;Data Collection;Depressed mood;detection method;Development;developmental disease;digital;Disabling;Distress;Ecological momentary assessment;Ethnic Origin;Face;Family member;follow-up;Frequencies;Friends;Gender;Head;Head Movements;Human;Impairment;impression;improved;Incidence;Individual;Intervention;Interview;Low Back Pain;Measurement;Measures;Metadata;Methods;Modality;Modeling;Monitor;Movement;movement analysis;multimodal fusion;multimodality;Musculoskeletal Pain;neurocognitive disorder;Pain;pain chronification;Pain Disorder;Pain intensity;Pain management;Pain Measurement;pain score;Participant;Pathway interactions;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physicians;prevent;Procedures;Provider;Psychological Factors;psychosocial;Psychosocial Factor;Psychosocial Stress;Qualifying;Reporting;Research Personnel;Risk;Risk Factors;Rotation;Sacroiliac joint structure;Sampling;Slipped Disk;social factors;Spinal Stenosis;standard of care;Subgroup;Suggestion;Syndrome;System;Technology;Testing;Thinness;Time;Training;treatment response;United States National Institutes of Health;Variant;Video Recording;Visit;Visual

PROJECT_TITLE: Efficient and Cost-Effective Multimodal System for Pain Management in Low Back Pain

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project addresses a significant unmet medical need for curbing metabolic dysfunctions in obesity by investigating a novel mechanism underlying adipose tissue pathological remodeling. The proposed studies will establish the role of Immunoglobulin G (IgG) in adipose tissue dysfunction and further elucidate the regulatory and functioning mechanisms. This project will provide a novel therapeutic strategy by targeting IgG recycling to treat obesity and comorbidities.

PI_NAMEs: FERRANTE, ANTHONY W (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Aging;Antibodies;Antisense Oligonucleotides;Automobile Driving;Biochemical;Biological Response Modifiers;Caloric Restriction;Cardiovascular Diseases;Cells;Chronic;comorbidity;conditional knockout;Data;Dependence;Development;diet-induced obesity;Drug or chemical Tissue Distribution;Dyslipidemias;effective intervention;energy balance;Fibrosis;Functional disorder;Genes;Half-Life;Health;High Fat Diet;Homeostasis;Hypertrophy;Immune;Immunoglobulin G;Immunologic Factors;Impairment;improved;in vitro Model;in vivo;Inflammation;Inflammatory;insight;Insulin Resistance;insulin sensitivity;Knock-out;Knockout Mice;Label;Ligands;Light;lipid biosynthesis;Liver diseases;LoxP-flanked allele;MADH3 gene;Malignant Neoplasms;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modeling;Molecular;mouse genetics;Mus;Myeloid Cells;neonatal Fc receptor;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obese Mice;Obesity;overexpression;Pathologic;Pathology;Peroxisome Proliferator-Activated Receptors;Phenotype;prevent;Prevention;Production;progenitor;Proteins;Recycling;Repression;Role;Signal Transduction;stem cells;Stromal Cells;Testing;Therapeutic;Thinness;Tissues;TLR2 gene;TLR4 gene;Virulence Factors;Weight Gain;Work

PROJECT_TITLE: IgG and Adipose Pathological Remodeling

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Nonalcoholic fatty liver disease is a common and serious public health problem. No effective therapies are currently available, in part due to insufficient understanding of the factors that influence disease progression. We propose to use state-of-the-art genomic tools and genetic and disease models to investigate how a unique type of disease-associated macrophages are regulated and contribute to disease pathogenesis.

PI_NAMEs: LIN, JIANDIE D (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Ablation;Address;Adopted;Benign;Biology;Bone Marrow;Calcium;Cell Separation;cell type;Cells;chronic liver injury;Cirrhosis;Clinical;conditional knockout;Data;design;Development;Development Plans;Diet;dietary;Dimensions;Disease;disease model;Disease Progression;effective therapy;end stage liver disease;Exhibits;Fatty Liver;Fibrosis;Foundations;Future;Genetic;Genetic Models;genetic signature;Genetic Transcription;genomic tools;Hepatocyte;Heterogeneity;Homeostasis;Host Defense;Human;Inflammasome;Inflammation;Injury;insight;Insulin Resistance;intrahepatic;Knock-in;Knockout Mice;Knowledge;Link;Lipids;Liver;Liver Fibrosis;Macrophage;Malignant neoplasm of liver;Mediating;Membrane;Metabolic Diseases;Modeling;Molecular;Mus;Myelogenous;Nature;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity Epidemic;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Pattern;Play;Population;Prevalence;Primary carcinoma of the liver cells;Public Health;Regulation;response;Risk;Role;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stimulus;TGFBR1 gene;Therapeutic;Tissues;tool;transcriptome;transcriptomics;Transgenic Organisms;translational study;TREM2 gene;tumor microenvironment;Urokinase

PROJECT_TITLE: NASH-associated macrophages: regulation and role in disease pathogenesis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: 8. PROJECT NARRATIVE Opioid use disorder continues to exert a significant toll on morbidity and mortality in the U.S., yet a pervasive gap remains in engaging the most vulnerable patients in continuous use of evidence-based treatment with medications for opioid use disorder. The proposed research aims to address a lack of knowledge regarding effective strategies for transitioning opioid use disorder patients from interventions that initiate medications in hospital settings to ongoing treatment in the community. This K01 will uncover evidence to better support integrated care services for opioid use disorder across health system touchpoints, while supporting a new investigator in advancing towards an independent research career dedicated to promoting equitable access to evidence-based addiction health services.

PI_NAMEs: KRAWCZYK, NOA  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Accident and Emergency department;Active Learning;acute care;addiction;Address;Award;Buprenorphine;care systems;career;Caring;Case Study;Characteristics;Classification;Clinical;clinical practice;cognitive interview;Communities;community barrier;Competence;Comprehension;Data;Data Collection;Data Set;Dedications;Discharge Plannings;diverse data;Effectiveness;Electronic Health Record;Ensure;Epidemic;Epidemiology;Equity;evidence base;Evidence based practice;Evidence based treatment;follow-up;Frequencies;Future;Goals;Grant;Harm Reduction;Health;health care settings;Health Services;Health Services Research;Health system;Healthcare;high risk;Hospital Referrals;Hospitalization;Hospitals;implementation research;Improve Access;improved;Individual;Inpatients;Institution;integrated care;Intervention;Intervention Studies;Interview;Knowledge;Life;Link;Medicaid;medical schools;medication for opioid use disorder;meetings;Mentored Research Scientist Development Award;Mentorship;Methadone;Methods;Modeling;Morbidity - disease rate;mortality;multilevel analysis;Naltrexone;National Institute of Drug Abuse;Nature;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;Participant;patient-level barriers;Patients;Perception;Persons;Pharmaceutical Preparations;Policies;prevent;programs;Provider;provider-level barriers;Public Hospitals;Qualitative Methods;Questionnaires;rapid growth;Reporting;Research;Research Personnel;Review Literature;Role;Series;Services;skills;sociodemographics;standard care;Structure;Substance Use Disorder;substance use treatment;success;Surveys;symposium;Taxonomy;Training;Treatment outcome;treatment services;uptake;virtual;Wages;Work;Writing

PROJECT_TITLE: Beyond Treatment Initiation: Enhancing Opioid Use Disorder Care Transitions Across Health System Touchpoints

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Sleep Research

ORG_CITY: MADISON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The prevalence of metabolic diseases, including obesity, has increased at an alarming rate over the past 50 years, and treatment currently commands enormous public health resources, especially in children and adolescents. Clinical and preclinical data indicate a causal role for disrupted circadian rhythms in the development of obesity, but how metabolic signals early in life impact the development of circadian rhythms in metabolism remains unclear. The goal of this proposal is to determine how diet and the gut microbiota— during circumscribed windows of early development— shape the expression and plasticity of circadian rhythms and metabolic outputs over the lifespan, and thereby dispose individuals to diet-induced obesity.

PI_NAMEs: LEONE, VANESSA ANNE (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Abate;Address;Adolescent;Adult;Affect;Age;aged;Automobile Driving;Behavior;Behavioral;Birth;Brain;Child;circadian;circadian behavioral rhythms;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical Data;Consumption;Data;Development;Diet;diet-induced obesity;dietary;Disease;disorder risk;effective intervention;Elements;Epidemic;Exhibits;experimental study;Fatty acid glycerol esters;Feedback;feeding;Feeding behaviors;Gene Expression;Genetic Transcription;Genomics;Germ-Free;global health;Gnotobiotic;Goals;gut microbes;gut microbiota;Health;Health Resources;healthcare burden;Hepatic;host-microbe interactions;Individual;innovation;insight;Intervention;Investments;Knowledge;Life;life span;liver metabolism;Metabolic;Metabolic Diseases;Metabolism;Microbe;microbial;microbial community;microbial host;microbiome;microbiota;Molecular;Mus;novel;Obese Mice;obese person;Obesity;obesity development;obesity in children;obesogenic;Outcome;Output;Overweight;Pattern;Periodicity;Persons;Phenotype;Physiologic Thermoregulation;Physiology;Play;Population;pre-clinical;Pregnancy;Prevalence;programs;Prophylactic treatment;Public Health;Research;Ribosomal RNA;Risk;Role;Severities;Shapes;Signal Transduction;Specific qualifier value;Sterility;sugar;System;Telemetry;Testing;Thinness;transcriptome sequencing;transcriptomics;Weaning;western diet;wireless

PROJECT_TITLE: Developmental effects of intestinal microbes on metabolic and behavioral circadian rhythms


NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Although conventional dendritic cell type 2 (cDC2) plays a pivotal role in multiple diseases, the cDC2 specific mouse model is undeveloped. This proposal investigates CX3CR1+cDC2-mediated cellular hierarchy of lung cDC2 and suggests the CX3CR1+cDC2 is a key player in cDC2 associated disease.

PI_NAMEs: PARK, GYE YOUNG  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acute;adaptive immunity;Address;Adopted;Adoptive Transfer;Affect;airway inflammation;Allergic;Alveolar Macrophages;Animal Model;Aspergillus;Attenuated;Bioinformatics;Blood;Categories;Cell Count;cell type;Characteristics;Collaborations;CX3CR1 gene;Data;Dendritic Cells;Development;Disease;Extrinsic asthma;Gene Expression;Heterogeneity;high dimensionality;Hypersensitivity;Immune response;Immunity;Inflammation;insight;interest;ITGAX gene;Knowledge;Lung;Lung Diseases;Lymphoid Cell;Malignant Neoplasms;Maps;Mediating;Modeling;mouse model;Mouse Strains;Mus;Mycoses;Myeloid Cells;Natural Immunity;novel;Operative Surgical Procedures;Parabiosis;Parasitic infection;Play;Population;Pulmonary Inflammation;Reporter;Research;Rest;RNA;Role;single-cell RNA sequencing;Specificity;Stains;Techniques;Testing;tool;transcriptomic profiling;transcriptomics

PROJECT_TITLE: Heterogeneity and cellular hierarchy of lung cDC2

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: NMR spectroscopy is a primary tool for metabolomics and the structural biology of proteins, membrane proteins and complexes they form, providing powerful means for understanding how structure, dynamics, and chemistry drive functional mechanisms. Here, we advance the sensitivity and spectral resolution of NMR technology in multiple ways that will lead to new tools for biomedical science that provide novel insights into metabolic flux, enzyme mechanisms, structure-function relationships for many drug targets, mechanisms of intrinsically disordered proteins, and cell wall structure. We interface to NIH-funded programs aimed at addressing nonalcoholic fatty liver disease, gene regulation, amino acid synthesis, bacterial biofilms, fungal infections, bacterial drug resistance, and drug development.

PI_NAMEs: BREY, WILLIAM W;LONG, JOANNA R;SCHURKO, ROBERT  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Amino Acids;analytical tool;Applied Research;Area;Automobile Driving;Bacterial Drug Resistance;Basic Science;Biochemical;Biological;Biology;Biomedical Research;biomedical scientist;Biomedical Technology;Biopolymers;Cell Wall;Chemicals;Chemistry;cold temperature;Communities;community engagement;Complex;Complex Mixtures;Cryoelectron Microscopy;Dedications;design and construction;Disease;drug development;drug resistance development;Drug Targeting;Education;Educational Activities;Educational workshop;Electronics;Electrons;Environment;enzyme mechanism;frontier;Funding;Gene Expression Regulation;Generations;Goals;High temperature of physical object;Hybrids;Hydrogen;improved;Information Technology;Infrastructure;insight;instrument;instrumentation;International;kinetic model;Kinetics;Laboratories;lectures;Licensing;Macromolecular Complexes;macromolecule;magnetic field;Mass Spectrum Analysis;Measures;meetings;Membrane Proteins;Mentors;Metabolic;metabolomics;Metals;Microbial Biofilms;Mycoses;new technology;news;NMR Spectroscopy;non-alcoholic fatty liver disease;novel;Nuclear;Nuclear Magnetic Resonance;open data;outreach;Positioning Attribute;Process;programs;Proteins;Protons;Publications;Regulation;Research;Research Personnel;Resolution;Resources;RF coil;Roentgen Rays;Sampling;Science;scientific organization;Scientist;Series;Services;Signal Transduction;solid state nuclear magnetic resonance;Structural Biochemistry;structural biology;Structure;Structure-Activity Relationship;Technology;technology development;Temperature;tool;Training;Training Activity;Training and Education;United States National Institutes of Health;web site;Work;X-Ray Crystallography

PROJECT_TITLE: National Resource for Advanced NMR Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-P(55)R]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE This proposal will test the efficacy of thawed cryopreserved cultured thymus tissue implantation (cCTTI) versus implantation of freshly cultured thymus tissue (CTTI) to reconstitute the immune system of conditioned recipients, using a pig model. Results will advance the goal of developing immune tolerance to a heart transplanted from the thymus donor, which would revolutionize transplantation of the heart and other solid organs by preventing the chronic rejection and need for immunosuppression that currently limit allograft and patient survival following transplantation.

PI_NAMEs: HALE, LAURA P.;TUREK, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Allogenic;Allografting;Animal Model;Antigen Presentation;Autologous Transplantation;Back;Biopsy;Cell Count;Child;Chronic;Clinical;clinical efficacy;conditioning;Contralateral;Cryopreservation;Data;Development;Donor person;Dose;efficacy testing;Evaluation;Exhibits;Family suidae;Fibrosis;Fibrous capsule of kidney;Flow Cytometry;Goals;graft vs host reaction;Harvest;Heart;heart allograft;heart damage;Heart Transplantation;Human;human tissue;immune reconstitution;Immune system;Immune Tolerance;Immunocompetent;Immunosuppression;Implant;implantation;improved;In Vitro;in vivo;Infant;Infection;Institution;isoimmunity;Life;Mediating;Methods;Molecular Analysis;Monitor;Muscle;Organ;Organ failure;Organ Transplantation;patient tolerability;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Population;porcine model;post-transplant;pre-clinical;preservation;prevent;Probability;progenitor;programs;public health relevance;quadriceps muscle;Rattus;reconstitution;Risk;Slice;Solid;Steroids;T cell reconstitution;T-Lymphocyte;Techniques;Testing;Thigh structure;Thymectomy;Thymic Tissue;thymocyte;Thymus Gland;thymus transplantation;Tissues;Translating;translation to humans;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Transplantation of Cryopreserved Thymus

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative: Kaposi's Sarcoma is the most common tumor of AIDS patients worldwide and is caused by the Kaposi's Sarcoma-associated herpesvirus. KSHV is present in the latent state in the KS tumor cells, cells of endothelial origin. Through the study of how cellular metabolic processes are required for KSHV latent infection of endothelial cells, we will identify novel therapeutic targets to inhibit latency and therefore, KS tumors. !

PI_NAMEs: LAGUNOFF, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Africa South of the Sahara;Antigens;cancer cell;cancer survival;Carbon;Cell Death Induction;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Stress;Chromosome Mapping;Common Neoplasm;CRISPR screen;Data;Electron Transport;Endothelial Cells;Endothelium;Etiology;Fatty Acids;FDA approved;functional outcomes;gammaherpesvirus;Genes;Glycolysis;Glycolysis Induction;Goals;Herpesviridae;Human;Human Herpesvirus 8;Infection;inhibitor;Intervention;Kaposi Sarcoma;latent infection;Life Cycle Stages;Lipids;long chain fatty acid;Lytic;Lytic Phase;lytic replication;Malignant Neoplasms;Measurable;Metabolic Control;Metabolic Pathway;Metabolism;Mitochondria;Modeling;neoplastic cell;new therapeutic target;oxidation;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;Patients;Pharmaceutical Preparations;Proliferating;Proteins;Reporting;Role;Spindle Cell Sarcomas;Stress;Structure;Supporting Cell;Therapeutic;therapeutic target;Translations;tumor;Vascularization;Viral

PROJECT_TITLE: KSHV alteration of cellular metabolism


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Axon regeneration after peripheral nerve (PN) injury is often incomplete, thus deciphering the repair mechanisms is critical. This proposal investigates a previously unknown function of the core circadian regulator Bmal1 in gating neural regenerative responses and immune activation after PN injury. Our study will link Bmal1 circadian clock, epigenetic rhythms, and intriguing time-of-day differences of axon regenerative responses, thus establishing a new paradigm to enhance nerve repair by modulating circadian/ epigenetic pathways.

PI_NAMEs: ZOU, HONGYAN JENNY (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acceleration;Address;Affect;Afferent Neurons;Agonist;ARNTL gene;Axon;axon growth;axon injury;axon regeneration;Axotomy;Basic Science;beta catenin;Binding;Bioinformatics;Biological Assay;Brain-Derived Neurotrophic Factor;cell type;Chromatin;circadian;circadian biology;circadian pacemaker;Clinical;Cohort Studies;Collaborations;comparative efficacy;conditional knockout;Data;design;DNA mapping;effective therapy;efficacy evaluation;Enzymes;Epigenetic Process;Exhibits;Gatekeeping;gene induction;Genes;Genetic;Genetic Transcription;genome-wide;genomic locus;Hour;Immune;immune activation;Immune response;Immunologics;In Vitro;in vivo;inhibitor;Injury;insight;Investigation;Knockout Mice;Laboratories;Link;Maps;Mediating;Metabolism;Modeling;Molecular;Mus;Natural regeneration;nerve injury;Nerve Regeneration;nerve repair;neural;Neurites;Neuroimmune;Neurons;novel;Output;Pathway interactions;Penetration;Periodicity;Peripheral;Peripheral nerve injury;pharmacologic;Phase;Phenotype;Pilot Projects;Process;programs;Reconstructive Surgical Procedures;recruit;regenerative;Regenerative response;Regulation;repaired;Reporting;response;Rest;Role;sciatic nerve injury;Series;sex;Sex Differences;Shapes;Signal Transduction;Spinal Ganglia;Testing;Time;transcription factor;transcriptomics;Work

PROJECT_TITLE: The Role of Core Circadian Regulator Bmal1 in Axonal Regeneration and Nerve Repair

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: Public Health Relevance Statement The Middle East and North Africa (MENA) region faces a myriad of environmental and occupational health (EOH) challenges in a context of dynamic political changes and multiple concurrent humanitarian crises. The proposed collaborative U01 (led by the American University of Beirut, Lebanon) and U2R (led by Yale University in collaboration with the University of Iowa in the US) applications aim to establish a Global Environmental and Occupational Health Research and Training Hub for the MENA region (GEOHealth MENA) with the goal to build and strengthen EOH research capacity at academic/research institutions and relevant NGOs in the region. With the purpose of informing policy and practice guidelines, the U01 research project will evaluate pathways of pesticide exposure among Syrian refugee agricultural workers, investigate its association with neurobehavioral performance, and explore the role of social factors in this association, while providing a platform for short-term (workshops, courses) and long-term training (MPH, PhD) to health professionals from the MENA region supported by the U2R.

PI_NAMEs: HABIB, RIMA ;MOWAFI, HANI  (contact);NUWAYHID, IMAN A;REDLICH, CARRIE A;ROHLMAN, DIANE S;SAKR, CARINE

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Agricultural Workers;Agriculture;American;Collaborations;Communities;Country;Disparity population;displaced person;Doctor of Philosophy;Egypt;Environmental Health;Epidemiology;Exposure to;Face;Faculty;Fellowship;global environment;Health;Health Sciences;health training;improved;Institution;Interdisciplinary Study;Investments;Iowa;Lebanon;low and middle-income countries;Medicine;Middle East;Migrant;neurobehavioral;Northern Africa;Occupational Health;Occupational Medicine;Outcome;Pathway interactions;Performance;pesticide exposure;Pesticides;Policies;Politics;Population;Practice Guidelines;Qualifying;Refugees;Regulation;Research;Research Training;Role;Safety;Scholarship;Sister;social factors;Sudan;Training;Translating;Universities

PROJECT_TITLE: 2/2 Global Environmental and Occupational Health Hub for Research Training in the Middle East and North Africa Region (GEOHealth MENA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Rehabilitation;Social Determinants of Health;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Kidney transplant is superior to dialysis for the treatment of end-stage kidney disease, but access to transplant remains limited in underserved communities. To get a transplant, patients must navigate a complicated healthcare system, but the current approach to supporting patients is not patient-centered, inadvertently favoring patients at ease in healthcare settings and with higher socioeconomic status. Feasible strategies to improve access to transplant in safety net hospital settings are critical to providing equitable access.

PI_NAMEs: HART, ALLYSON  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: acceptability and feasibility;Address;Appointment;Behavioral;Behavioral trial;Body Weight decreased;Cardiac;Chronic Disease;Clinic;Clinical;clinical practice;Clinical Trials;clinically significant;Collaborations;comorbidity;Complex;Conflict (Psychology);Counseling;Data;Decision Making;design;Development;Dialysis patients;Dialysis procedure;Disease;Donor person;Education;efficacious intervention;efficacy evaluation;empowerment;End stage renal failure;Enrollment;Equity;Ethnic Population;Evaluation;Feedback;Future;health care settings;health literacy;Healthcare Systems;Home visitation;Hospitals;implementation evaluation;implementation outcomes;Improve Access;improved;Individual;insight;Intention;Intervention;Interview;Kidney Transplantation;Life;Living Donors;Longevity;low socioeconomic status;Medical;member;Minnesota;Mission;Motivation;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Patient Education;patient engagement;Patient risk;Patients;Physicians;Population;post-transplant;Process;Protocols documentation;Provider;Quality of life;racial population;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Relative Risks;Research;Research Support;Resources;response;Risk;risk perception;safety net;Self Efficacy;Site;Social support;Socioeconomic Status;support network;Surveys;System;Testing;Transplantation;treatment as usual;underserved community;Underserved Population;United States;virtual;virtual coach;virtual intervention;Waiting Lists;Work

PROJECT_TITLE: Virtual coaching for potential kidney transplant candidates and their social support networks

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  A hallmark feature of heart failure is decreased exercise tolerance. Even in normal subjects, dynamic exercise presents one of the greatest challenges to cardiovascular control and this challenge is markedly exacerbated in heart failure resulting in often profound increases in sympathetic nerve activity which can elicit vasoconstriction of the inactive vascular beds such as the kidney and even the coronary circulation as well as the active skeletal muscle. The focus of this proposal is to determine the mechanisms mediating the extreme activation of the sympathetic nervous system during exercise in patients with heart failure.

PI_NAMEs: O'LEARY, DONAL S (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute;Address;Affect;afferent nerve;Age;American;Amplifiers;Anesthesia procedures;Animals;Attenuated;Baroreflex;Beds;Blood flow;blood pressure control;Buffers;canine model;Cardiac;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Chronic;Complex;Conscious;Coronary;Coronary Circulation;coronary vasculature;coronary vasoconstriction;Country;Data;Depressed mood;Diagnosis;Disease;Excision;Exercise;exercise intolerance;Exercise Tolerance;Experimental Designs;Fatigue;Feedback;Goals;Health;Heart;Heart failure;hemodynamics;improved;Incidence;innovation;instrument;instrumentation;Investigation;Ischemia;Kidney;Knowledge;Laboratories;longitudinal design;Longitudinal Studies;Measurement;Mediating;Metabolic;Minority Groups;Muscle;Nerve;neuroregulation;Newly Diagnosed;Operative Surgical Procedures;pandemic disease;Patients;Peripheral;Prognosis;receptor;Reflex action;Research Design;response;Rest;restraint;skeletal;Skeletal Muscle;Source;stem;Sympathetic Nervous System;Symptoms;Techniques;Testing;Time;Trauma;Treatment Cost;TRPV1 gene;United States;vascular bed;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Ventricular Function;Work

PROJECT_TITLE: Blood Pressure Control During Exercise in Heart Failure

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Narrative  This study aims to learn the causes of population differences in genetic risks of schizophrenia through studying genetic regulators of brain gene expression in donors of East Asian, African, and European ancestry, and create a novel algorithm to impute genetically-regulated brain gene expression based on genotype data of diverse genetic backgrounds. The study will improve our understanding of the biological mechanism of schizophrenia and discover novel risk genes either specific to populations or shared across populations, with significant implications for addressing human diversity, health disparities and for developing precision medicine.

PI_NAMEs: LIU, CHUNYU  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Address;Affect;African;African ancestry;Algorithms;Asian ancestry;Autopsy;Biological;Biology;Brain;brain cell;Brain Mapping;brain tissue;causal variant;cell type;China;Chinese;Collection;Copy Number Polymorphism;Data;Data Set;Diagnosis;differential expression;Disease;disorder risk;Disparate;Disparity population;diverse data;East Asian;epigenomics;European;European ancestry;Foundations;frontal lobe;Gene Expression;Gene Expression Regulation;Gene Frequency;gene function;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic study;Genetic Transcription;genome wide association study;genomic locus;Genotype;health disparity;health disparity populations;Heritability;Human;improved;Individual;insight;Learning;Linkage Disequilibrium;Maps;Mediator;Mendelian randomization;Mental disorders;Methods;novel;Ontology;Pathway interactions;Patients;Population;Population Analysis;Population Heterogeneity;Population Study;precision medicine;Precision therapeutics;preservation;Protein Isoforms;psychogenetics;Quantitative Trait Loci;Race;rare variant;Regulatory Element;Reporting;Resources;Rest;risk variant;RNA Splicing;Sampling;Schizophrenia;schizophrenia risk;Sex Bias;Signal Transduction;Single Nucleotide Polymorphism;Specificity;Spliced Genes;Structure;Testing;Tissues;transcriptome;transcriptomics;Universities;Variant

PROJECT_TITLE: Gene Expression Regulation in Brains of East Asian, African, and European Descent Explains Schizophrenia GWAS in Diverse Populations.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Lymphatic Research;Patient Safety;Women's Health Research

ORG_STATE: IL

PHR: NARRATIVE The status of the axillary lymph nodes is one of the strongest prognostic factors in patients with breast cancer, and the sentinel lymph node (SLN) biopsy has become the standard of care in the assessment of metastatic spread to the lymph nodes (LN). Current SLN biopsy procedures are limited by a lack of real-time intraoperative visualization tools to accurately distinguish between LN metastases and healthy LN. The overall objective is to determine whether our intraoperative imaging approach can accurately distinguish between LN metastases and healthy LN in mimicked intraoperative settings (animal surgery) with multiple validations and the double-blinded procedure.

PI_NAMEs: YAMADA, TOHRU  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: afferent nerve;Animal Cancer Model;Animals;Area;arm;Articular Range of Motion;Axilla;Axillary Lymph Node Dissection;Axillary lymph node group;Blinded;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Treatment;breast lumpectomy;cancer cell;cancer surgery;Clinical;Clinical Research;collaborative environment;cost;cost effective;Data;Detection;Development;Diagnosis;Diagnostic Procedure;Disease;Dissection;Double-Blind Method;Dyes;Excision;flexibility;Health;Image-Guided Surgery;imaging agent;imaging approach;improved;Injections;Location;Lymph Node Involvement;lymph nodes;lymphadenopathy;Lymphedema;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mastectomy;Medical;Metastatic breast cancer;Metastatic Neoplasm to Lymph Nodes;Methods;Neoplasm Metastasis;nerve injury;operation;Operative Surgical Procedures;Optical Instrument;Outcome;Palpable;Pathologic;Pathological Staging;Patients;Phase;Postoperative Complications;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;Procedures;Process;Prognostic Factor;prognostication;Property;Protocols documentation;Published Comment;Radioactive Tracers;real-time images;Reporting;Research;Sentinel Lymph Node;Sentinel Lymph Node Biopsy;Seroma;Side;Staging;Stains;standard of care;stem;Surgeon;Technetium;Testing;Time;tool;Toxic effect;Translating;tumor;United States National Institutes of Health;Unnecessary Surgery;Validation;Visualization;Visualization software

PROJECT_TITLE: Intraoperative Imaging for Lymph Node Metastases


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Pregnancy requires adaptation by many maternal organs, including the heart, but precisely how the heart responds to the dynamic changes of pregnancy and the postpartum periods is poorly understood. Here, we present novel data suggesting that prolactin receptor (PRLR) signaling is critical for the normal response of the heart to the physiologic stress of pregnancy, and resolution of those adaptations in the postpartum. Understanding the molecular mechanisms underlying adaptations driven by cardiac PRLR signaling will reveal novel insights into the biology of the heart during pregnancy and may predict novel targets to improve heart function during pregnancy in health and disease.

PI_NAMEs: BANERJEE, RONADIP RALPH;YOUNG, MARTIN E (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acute;Adipose tissue;Adult;Adverse effects;Age;Biology;Birth;blood glucose regulation;Breast Feeding;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular system;Categories;Classification;Clinical;Data;Development;Discipline of Nursing;Disease;Echocardiography;Endocrine;Ensure;Exercise;Failure;Female;fetal;Fetal Development;Fibrosis;functional adaptation;Functional disorder;Gene Expression;Genetic;Goals;Grant;Growth;Health;Heart;Heart Diseases;Heart failure;heart function;Histologic;Homeostasis;Hormones;Human Milk;improved;Individual;insight;insulin secretion;insulin signaling;Isotopes;Lactation;lactation period;lactogenesis;lipid metabolism;LoxP-flanked allele;Mammary gland;Mammary Gland Parenchyma;Mediating;meetings;Metabolic;Metabolism;milk production;Modeling;Molecular;Mothers;mouse model;Mus;Myocardial;Myocardium;National Institute of Child Health and Human Development;Nature;novel;Nurses;Organ;Outcome;Pathologic;Pathway interactions;Performance;peripartum cardiomyopathy;physiologic stressor;Physiological;Postpartum Period;Pregnancy;Pregnant Women;pressure;Process;programs;Prolactin Receptor;Prolonged Lactations;protein expression;Radiolabeled;Receptor Signaling;Research;Resolution;response;Role;Signal Transduction;Stimulus;Stress;stressor;Structure;Structure of beta Cell of islet;Testing;Tissues;Transcriptional Regulation

PROJECT_TITLE: Prolactin receptor signaling regulates adaptation of the heart during pregnancy and postpartum

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Cardiovascular;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity

PHR: PROJECT NARRATIVE We plan to determine why post-exertional malaise occurs, to which patients and at what level of severity. The changes in cardiopulmonary physiology reported to occur on the second of two sequential days of maximal exercise testing have been reported to be a physiological manifestation of PEM. This proposal seeks to use this two day exercise protocol to understand the physiology of PEM and how it is linked to its behavioral manifestations of reduced activity and markedly increased symptoms.

PI_NAMEs: MANCINI, DONNA M;NATELSON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: actigraphy;Address;Affect;Age;Anaerobic Threshold;Attention;Behavioral;Blood Volume;Body mass index;Breathing;Cardiopulmonary;Cardiopulmonary Physiology;Cardiovascular system;Categories;Chronic Fatigue Syndrome;Clinical;Cognitive;Data;digital;disability;Disabling;early onset;Exercise;Exercise Test;Exertion;exhaustion;Fatigue;Feeling;fitness;Gender;Goals;Hour;Hypovolemia;Hypovolemics;Infusion procedures;Intravenous;Isotonic Exercise;Link;Liquid substance;Malaise;Measures;Metabolic;Methods;Muscle;Noble Gases;Oxygen Consumption;Patients;phenomenological models;Physiological;Physiology;prevent;Probability;Protocols documentation;Randomized;Reporting;Research;Research Personnel;Role;Saline;Severities;Severity of illness;Stroke Volume;Subgroup;Sweating;Symptoms;Testing;Time;Woman;Work

PROJECT_TITLE: A Cardiovascular Analysis of Post-exertional Malaise.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE Inflammatory bowel diseases (IBD) cause substantial mortality and morbidity. Current treatments that block pathological inflammatory responses have improved clinical outcomes in some patients but they are not highly effective in modifying disease progression or preventing relapses. Common genetic polymorphisms associated with disease risk can be utilized to identify molecular pathways, genes and cell types driving disease pathogenesis. As such, we have recently identified an association of LSP1 expression in CD4+ T cells with the risk for inflammatory bowel disease, and our work here will examine the role of LSP1 in CD4+ T cells in IBD pathogenesis, provide direct mechanistic insights, identify functional genetic variants and will aid to develop novel therapeutic targets for inflammatory bowel disease.

PI_NAMEs: SCHMIEDEL, BENJAMIN JOACHIM (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Affect;Apoptosis;Arthritis;Autoimmune Diseases;Automobile Driving;Binding;Biological Assay;Biological Sciences;causal variant;CD4 Positive T Lymphocytes;cell motility;Cell Physiology;cell type;Cells;chromatin immunoprecipitation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colitis;Collaborations;Colonic inflammation;CRISPR interference;Crohn's disease;cytokine;cytotoxicity;Databases;Delayed Hypersensitivity;Disease;Disease Progression;disorder risk;DNA Sequence;Enhancers;epigenomics;F-actin-binding proteins;Gene Expression;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic study;genetic variant;genome wide association study;Human;Immune;Immunology;Impairment;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Inherited;insight;Knowledge;Leukocytes;Link;loss of function;Luciferases;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;murine colitis;Mus;new therapeutic target;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;phase 3 study;Play;Production;programs;Proliferating;promoter;Proteins;Quantitative Trait Loci;Regulation;relapse prevention;Reporter;Reporting;response;Rest;restraint;Risk;risk variant;RNA Interference;Role;Science;Signal Pathway;Small Interfering RNA;T cell therapy;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic target;transcription factor;Translating;tumor;Ulcerative Colitis;Untranslated RNA;Variant;Work

PROJECT_TITLE: Genetic studies linking LSP1 function in T cells to Inflammatory Bowel Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Clinical Research;Hematology;Prevention

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative: Platelet transfusion is an essential therapy for the treatment and prevention of bleeding, yet a significant number of platelet transfusions fail to achieve the anticipated clinical effect. Oftentimes this is the result of antibody-mediated platelet clearance; however, we have recently found that CD8 T cells can cause accelerated loss of transfused platelets. Understanding the interactions between recipient CD8 T cells and transfused donor platelets may reveal new therapeutic strategies to inhibit platelet loss in patients requiring transfusion.

PI_NAMEs: MAIER, CHERYL  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acceleration;adaptive immunity;Alloantigen;Allogenic;Antibodies;Antigens;Asialoglycoprotein Receptor;Award;Basic Science;Bioinformatics;Biology;Biomedical Engineering;Blood;Blood Platelets;career;career development;Categories;CD8-Positive T-Lymphocytes;Cell Communication;Cell-Mediated Cytolysis;Cellular biology;clinical effect;Consumption;cost;cytotoxicity;Data;design;Disease;Doctor of Philosophy;effective therapy;Etiology;Excision;experience;experimental study;Exposure to;Funding;Future;Glycobiology;Goals;Granzyme;Hemorrhage;Hemostatic function;Hepatic;Idiopathic Thrombocytopenic Purpura;Immune;Immunization;Immunologic Memory;Intravenous Immunoglobulins;Isoantibodies;Laboratory Study;Ligands;Major Histocompatibility Complex;Mediating;meetings;Memory;Mentors;Methods;Minor;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;novel;novel therapeutic intervention;Outcome;Pathology;Pathway interactions;Patients;perforin;Platelet Activation;Platelet Count measurement;Platelet Transfusion;Play;Polysaccharides;Population;prevent;Prevention;Process;programs;Protocols documentation;receptor;Refractory;Reporting;Research;response;Role;Scientist;Signal Transduction;Site;skills;Specialist;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;Therapeutic Intervention;therapeutic target;therapy outcome;Thrombocytopenia;Time;TNFRSF5 gene;TNFSF5 gene;Training;transcriptome sequencing;transcriptomics;Transfusion;transfusion medicine;treatment strategy;Work

PROJECT_TITLE: CD8 T cell-mediated allogeneic platelet clearance


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Narrative Glioblastoma multiforme (GBM) is a malignant primary brain cancer which carries a dismal prognosis. STAT3 has been shown to be a very attractive therapeutic target for GBM; albeit, small molecule inhibitors of STAT3 signaling are ineffective, as they exhibit very poor blood brain barrier permeability. Our interdisciplinary team will develop and evaluate a novel and scalable bi-compartmental nanoparticle delivery system that allows controlled co-release of STAT3 siRNA and the chemotherapeutic agent, paclitaxel. This work may result in a new treatment modality for GBM, a tumor type, for which no effective treatments exist.

PI_NAMEs: CASTRO, MARIA G;LAHANN, JOERG  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Accounting;Adjuvant Chemotherapy;Albumins;Antibodies;Architecture;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Cancer Patient;Cell Death;cell type;Cells;chemotherapeutic agent;clinically relevant;Combined Modality Therapy;curative treatments;Data;design;Development;docetaxel;Dose;Doxorubicin;drug action;Drug Delivery Systems;Drug Kinetics;effective therapy;efficacy evaluation;Encapsulated;Excision;Exhibits;experimental study;Formulation;Glioblastoma;Glioma;Goals;Growth;Heterogeneity;Human;Immune;Immunity;immunogenic cell death;Immunologic Memory;improved;In Vitro;Infiltration;inhibitor;innovation;innovative technologies;Intracranial Neoplasms;Ionizing radiation;Knowledge;Malignant - descriptor;Malignant neoplasm of brain;Medial;Medical;Mission;Modality;Modeling;Molecular;Mus;nanoparticle;nanoparticle delivery;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Organ;Paclitaxel;Patients;Pattern;Penetration;Peptides;Phagocytes;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Polymers;pre-clinical;Prognosis;Proteins;Radiation therapy;Reporting;response;RNA;Serum Albumin;side effect;Signal Transduction;Signaling Molecule;Small Interfering RNA;small molecule;small molecule inhibitor;standard of care;Survival Rate;synthetic protein;System;T-Lymphocyte;targeted delivery;Techniques;Technology;temozolomide;Testing;Therapeutic;therapeutic target;Toxic effect;Transcription Factor 3;Transducers;Translating;Translations;Treatment Efficacy;tumor;tumor microenvironment;United States National Institutes of Health;uptake;Validation;Work

PROJECT_TITLE: Systemic Delivery of Targeted Bi-Compartmental Nanoparticles for Glioblastoma Therapeutics

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This proposal seeks support for the Society of Ear, Nose and Throat Advances in Children (SENTAC) annual scientific conference, to enhance diversity, equity, and inclusion. SENTAC facilitates the formation and dissemination of interdisciplinary knowledge about the care of infants and children with otolaryngology, hearing, speech, and swallowing disorders. The purpose of this grant is to support annual conferences for the next five years with a focus on enhancing diversity in membership and attendees, and support research presentations and educational sessions that focus on health inequities in the field of ear, nose, and throat disorders in children.

PI_NAMEs: MEINZEN-DERR, JAREEN ;ZACHARIAS, STEPHANIE RC (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Age;Allied Health Sciences;Ally;Applications Grants;Area;Award;career;Caring;Child;Child Support;Childhood;Clinical Research;Communities;Deglutition;Deglutition Disorders;demographics;Development;disability;Disabled Persons;disadvantaged background;Discipline;Disease;Disparity population;Ear;Education;Educational process of instructing;Educational workshop;empowerment;Equity;equity, diversity, and inclusion;ethnic minority;Ethnic Population;Evaluation;Event;experience;falls;Family;Fees;Funding;Future;Goals;Grant;health care availability;Health Disparities Research;health disparity;health inequalities;Health Professional;Hearing;Hearing problem;Hispanic;Historically Black Colleges and Universities;Individual;Infant Care;Institution;interest;Knowledge;Language;Leadership;Location;male;Medical;meetings;member;Mentors;Mentorship;Minority;minority student;multidisciplinary;Nose;Nurse Practitioners;Occupational Therapist;Operative Surgical Procedures;Otolaryngologist;Otolaryngology;outreach;Participant;Pathologist;pediatrician;personalized medicine;Pharyngeal structure;Physician Assistants;Physicians;posters;programs;racial minority;racial population;recruit;Request for Proposals;Research;Research Personnel;Research Support;response;role model;Scientist;Services;Societies;Socioeconomic Factors;South Carolina;Specialist;Speech;Speech Disorders;Speech Therapist;Students;Surveys;symposium;Time;Training;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Voice;Woman

PROJECT_TITLE: Society of Ears, Nose, and Throat Advances in Children (SENTAC)

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]